SGTCid condition conc unit PFD1|YJL179W.score PFD1|YJL179W.strain.pval PFD1|YJL179W.strain.significant PFD1|YJL179W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1643 st009866 20.2 µM 14.3165773313064 1.68970313683958e-44 yes 1 8.62037600959856e-47 4 3156273 YOR207C RET1
SGTC_2688 kanamycin b 96.69 µM 7.27121289028875 7.18355970443821e-13 yes 2 1.78136968491487e-13 95 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2582 agaric acid 100 µM 7.01536716110759 4.21065377785451e-12 yes 3 1.14672939066934e-12 127 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1803 st050068 52.4 µM 6.80525272401327 1.71902765932671e-11 yes 4 5.04360001283019e-12 58 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_212 3807-4682 38.772 µM 6.77751079851171 2.06353885077992e-11 yes 5 6.11320082631125e-12 20 3125501 YBL034C STU1
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 5.72046097118012 1.27707334842931e-08 yes 6 5.31177150423394e-09 17 6728940
SGTC_163 TUB2.036 7.546 µM 5.46451979927124 5.18350497753777e-08 yes 7 2.32080787395284e-08 57 15992207 YJR013W GPI14
SGTC_1875 nocodazole 6 µM 5.14147819992354 2.78694666259586e-07 yes 8 1.36292642706481e-07 36 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_210 3551-0445 56.827 µM 4.86234586913669 1.10361657926985e-06 yes 9 5.80013494318883e-07 39 2865180 YOR207C RET1
SGTC_138 0850-0259 40.9225 µM 4.83085748809239 1.28320606788506e-06 yes 10 6.79731437054169e-07 153 6813004
SGTC_58 0957-0393 9 µM 4.80639894692739 1.4417321426424e-06 yes 11 7.68365506595504e-07 305 6997992
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 4.6117501369972 3.57286415953476e-06 yes 12 1.99646393074561e-06 16 6708760
SGTC_129 0088-0017 176.636 µM 4.30665021276774 1.38230825461319e-05 yes 13 8.28726948298878e-06 62 182446
SGTC_422 cantharidin 155 µM 4.28901649230683 1.49087618914325e-05 yes 14 8.97330240245476e-06 47 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_980 1473-0395 201 µM 4.26942014920806 1.62102285737531e-05 yes 15 9.79908972135651e-06 8 768876
SGTC_1597 7-benzyloxygramine 47.5 µM 4.24255151751012 1.81710247308551e-05 yes 16 1.10496394518405e-05 103 260807
SGTC_849 0386-0493 241 µM 4.16958583774003 2.46953136899374e-05 yes 17 1.52576834932906e-05 15 726119
SGTC_146 3448-8650 53.125 µM 4.1237775610597 2.98668760630181e-05 yes 18 1.86354422545655e-05 128 2891488 YIL048W NEO1
SGTC_2971 9092186 9.93 µM 4.1215838373575 3.01386337980956e-05 yes 19 1.88138243011033e-05 26 25236400
SGTC_535 2293-4129 48.2 µM 4.00990537162218 4.75210698233971e-05 yes 20 3.03715431962115e-05 58 396118 YIL048W NEO1
SGTC_3037 9091026 49.47 µM 4.00882178299434 4.7728860681364e-05 yes 21 3.05112230368427e-05 122 25236398 YIL048W NEO1
SGTC_1298 1079-1278 263 µM 3.87960769569872 7.96960127890219e-05 yes 22 5.23125352545308e-05 17 2840950
SGTC_1844 rapamycin 4 nM 3.7558848873146 0.000128382936177474 yes 23 8.636503935796e-05 176 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2168 5727979 200 µM 3.68039027394993 0.000170578576390825 yes 24 0.000116438626865532 23 695210
SGTC_2651 TUB2.036 5 µM 3.58161656369417 0.000245496670167076 yes 25 0.000170737360373524 188 15992207 YFL037W TUB2
SGTC_1754 st042065 16.137 µM 3.51935378200571 0.000307446426641593 yes 26 0.000216299709685228 217 1126236 YIL048W NEO1
SGTC_2437 5741531 144.16 µM 3.48148383275795 0.000351942638107433 yes 27 0.000249321941245925 58 2262990
SGTC_7 0192-1582 4.227 µM 3.45337408111153 0.000388763459030664 yes 28 0.000276810349113612 85 252616
SGTC_2957 9076800 11.52 µM 3.44003267446764 0.000407463071161028 yes 29 0.000290821980884825 33 16459615
SGTC_2785 7756463 72.73 µM 3.40108898395723 0.000466928186678683 yes 30 0.000335589880133639 50 2201551
SGTC_582 0987-0078 156 µM 3.29114986208289 0.000680928717332565 yes 31 0.000498893712968909 113 1625765
SGTC_735 3076-0345 636 µM 3.26675082259716 0.000739320996480632 yes 32 0.000543946943999601 59 2888990
SGTC_1702 st027038 51 µM 3.1961938236918 0.000935126685828505 yes 33 0.000696267662048593 39 5521182
SGTC_438 sphingosine 6.67 µM 3.1863387919776 0.000965984214989783 yes 34 0.000720428806610148 49 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3152 9099253 49.47 µM 3.18075065240147 0.000983894160787471 yes 35 0.000734470016247479 189 25236131
SGTC_2191 5911152 200 µM 3.17349877627262 0.00100759083219348 no 36 0.000753067683560617 42 2875902
SGTC_2475 5812728 15.03 µM 3.14658254401509 0.00110019638824076 no 37 0.000825953132967436 49 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_856 0433-0016 11.3 µM 3.12882232721123 0.00116550529935279 no 38 0.000877541987334228 42 3911780
SGTC_2352 9027995 87.8 µM 3.12406118875007 0.00118360680109164 no 39 0.000891866794665622 56 2997347
SGTC_2592 piperlongumine 83.33 µM 3.10764812684395 0.00124799900277413 no 40 0.000942912266652986 73 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 3.08806739049356 0.00132900352958982 no 41 0.00100731389842961 38 17037758
SGTC_2089 5281248 129.67 µM 3.07215189581642 0.00139835475395312 no 42 0.00106260775191477 58 2737878
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 3.0368588719336 0.00156408076198292 no 43 0.00119528676248786 120 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2656 pseudo-anisatin 100 µM 3.02868828771595 0.0016049153943255 no 44 0.00122808983447396 12 6708809 A neurotoxin.
SGTC_761 k216-0224 480 µM 3.02145270162899 0.00164188573311035 no 45 0.00125782469586044 67 1340404
SGTC_1800 st050079 29.0735 µM 3.00352159364421 0.00173687210594244 no 46 0.00133437304803065 222 3645560
SGTC_869 0564-0080 44.1 µM 2.97839383908174 0.00187840381922541 no 47 0.00144881694693485 72 6843321
SGTC_1318 1280-3875 124 µM 2.97787857566362 0.00188141268562417 no 48 0.00145125473763996 75 373245
SGTC_1454 4239-0054 42.6 µM 2.96392600865549 0.00196457203286317 no 49 0.00151870655444634 81 1340767
SGTC_2975 9084847 53.72 µM 2.94359206694402 0.00209175042054564 no 50 0.00162213655781969 85 27211724
SGTC_1067 clotrimazole 1.36 µM 2.94263947226092 0.00209788758783453 no 51 0.00162713579854887 90 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2156 5649887 115 µM 2.92995494058691 0.00218118014838797 no 52 0.00169505579383112 61 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1730 st033808 45.1 µM 2.92829243828357 0.00219231631602804 no 53 0.00170414655556419 105 1045166
SGTC_979 1426-2828 121 µM 2.92800567922829 0.00219424235660746 no 54 0.00170571906918607 78 747872
SGTC_1274 0865-0114 173 µM 2.86497706949932 0.00265674727227545 no 55 0.00208519719974947 69 870624
SGTC_149 3970-0822 46.1 µM 2.86054678402162 0.00269235344567601 no 56 0.00211455574722093 204 3114250 YBL034C STU1
SGTC_1783 st039459 87.517 µM 2.82388869906687 0.00300391204314364 no 57 0.00237224287565029 78 729761
SGTC_2864 9034755 47.6 µM 2.80709384974367 0.00315721443112973 no 58 0.00249953375397752 61 4930451
SGTC_879 0831-1030 162 µM 2.77443817944829 0.00347559647748791 no 59 0.00276485713135363 142 1549252
SGTC_3023 9089636 49.47 µM 2.75905029651702 0.00363538895101039 no 60 0.00289848060408148 40 17249241
SGTC_3094 9117742 49.47 µM 2.75549229575795 0.00367326199638078 no 61 0.00293019423325214 93 17149698
SGTC_2565 isoliquiritigenin 100 µM 2.75286816268999 0.00370142091601006 no 62 0.00295378404349533 102 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1093 fluphenazine 7.97 µM 2.74877856172133 0.00374569154921521 no 63 0.00299088913285509 83 6602611 An atypical antipsychotic.
SGTC_1050 3232-1156 69.3 µM 2.72851517236883 0.00397212791738578 no 64 0.00318100817166007 82 700529
SGTC_187 1488-2104 32.728 µM 2.72826137559542 0.00397504011456543 no 65 0.00318345683925883 95 2852859
SGTC_1084 voriconazole 435 nM 2.72451453314736 0.0040182563952878 no 66 0.00321980480871227 86 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_361 000s-0510 1.45 µM 2.71352713277637 0.00414742143444625 no 67 0.00332855581832913 118 660
SGTC_788 1182-0090 188 µM 2.69847377458176 0.00433041365794395 no 68 0.00348291130760549 188 5715185
SGTC_369 0957-0393 4.5 µM 2.63300001210083 0.0052130482216288 no 69 0.00423171721684793 100 6997992
SGTC_1539 benzyladenosine 56 µM 2.63289570260475 0.00521457358884817 no 70 0.00423301702498066 75 92208 A nucleotide analog.
SGTC_1045 1348-1485 165 µM 2.62143306664727 0.00538463617187609 no 71 0.00437804771907709 141 6810614
SGTC_1672 st016598 6.51 µM 2.61178623918177 0.0055315613180401 no 72 0.00450352760568116 172 4665860 YNL267W PIK1
SGTC_467 ro 31-8220 72.8 µM 2.58620971042032 0.00593848222054527 no 73 0.00485189353228995 182 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3338 9144300 39.5675 µM 2.58551500162843 0.00594989595053649 no 74 0.00486168207188489 98 4901274
SGTC_3189 9110682 49.47 µM 2.58435005790764 0.00596907907481947 no 75 0.00487813579454028 105 17122418
SGTC_978 1416-0512 87.4 µM 2.56228962481399 0.0063428456564577 no 76 0.00519922817893786 122 6814003
SGTC_221 trifluoperazine 10.304 µM 2.55660688387186 0.00644242207266096 no 77 0.00528492966861536 341 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_745 0469-0705 296 µM 2.55522735766794 0.00646680261379655 no 78 0.00530592292223914 122 3486736
SGTC_940 3232-1287 54.8 µM 2.51435392358888 0.00722718844581075 no 79 0.00596253463965199 136 1585493 YIL048W NEO1
SGTC_1939 st074455 53.6 µM 2.51208092623458 0.00727169854652111 no 80 0.00600107809667903 136 1644229
SGTC_170 4197-0004 226 µM 2.50206711299189 0.00747068082528023 no 81 0.00617352583481289 88 218692
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.49967381400126 0.00751894194292902 no 82 0.00621538514371609 113 16486 A toxic proline analog.
SGTC_6 0844-0013 19.835 µM 2.4972935613941 0.00756721214380852 no 83 0.00625726538863119 303 1584900
SGTC_935 2996-0153 430 µM 2.48795268000275 0.00775928697363767 no 84 0.00642404133987917 112 23738523
SGTC_2062 5245942 200 µM 2.48649357781195 0.00778967449422653 no 85 0.00645044490565007 124 1376160
SGTC_529 4076-0302 30.3 µM 2.47555817284011 0.00802076946612029 no 86 0.0066514044114843 106 5816522
SGTC_2022 5136654 200 µM 2.46871502194907 0.0081684308084571 no 87 0.00677995793245815 108 1713771
SGTC_989 1501-0895 10.3 µM 2.45605529559307 0.00844790821139824 no 88 0.00702357705295029 73 2830112
SGTC_473 2-arachidonoylglycerol 10 µM 2.4513991058216 0.0085527902157179 no 89 0.00711510370064842 115 5282280 An endocannabinoid.
SGTC_3066 9117245 49.47 µM 2.44824810822458 0.0086244138850626 no 90 0.00717763830432462 110 17176980
SGTC_2679 rapamycin 1 nM 2.44585385367017 0.00867918764275501 no 91 0.00722547823292411 292 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1727 st034309 9.9045 µM 2.44442866257177 0.0087119366138236 no 92 0.00725408848706394 191 870305
SGTC_547 1120-0019 610 nM 2.43426794650614 0.00894857209556138 no 93 0.00746097220447644 141 3676939
SGTC_1040 k898-0338 155 µM 2.43177563828142 0.00900746907710631 no 94 0.0075125055857044 122 20969351
SGTC_2391 6285546 200 µM 2.39808527808579 0.00983757449913873 no 95 0.00824051386962467 141 846083
SGTC_1502 4534-4282 27.7 µM 2.39190218736434 0.00999697201369094 no 96 0.00838065430970277 106 3278949
SGTC_740 k014-0057 261 µM 2.38639740418232 0.0101407753081374 no 97 0.00850717700488177 143 4012779
SGTC_3268 9137683 49.47 µM 2.38564358811767 0.0101606073184624 no 98 0.00852463264942819 84 1953228
SGTC_937 3122-0005 46.7 µM 2.37175454648587 0.0105321139607752 no 99 0.00885192366058896 151 759535
SGTC_3235 9132602 49.47 µM 2.37069839363405 0.0105608423145418 no 100 0.00887725626797327 146 4912240
SGTC_1578 josamycin 24.2 µM 2.36745693428913 0.0106494397806749 no 101 0.00895540219355747 110 5282165 A P450 substrate.
SGTC_1857 st056007 79.3 µM 2.36706081442864 0.0106603110244178 no 102 0.00896499315416246 86 619834
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.36578653643176 0.0106953483111227 no 103 0.00899590737478766 166 165506
SGTC_98 0074-0023 107.663 µM 2.34856123315645 0.0111789030352005 no 104 0.009423050068643 165 3563821
SGTC_2793 7325131 81.82 µM 2.34715203677358 0.011219290773444 no 105 0.00945876687451232 121 4176441
SGTC_3196 9111891 49.47 µM 2.34297436260487 0.0113397697524803 no 106 0.00956534880451056 111 18891510
SGTC_2705 st078069 42.8 µM 2.33525394295013 0.0115653779283766 no 107 0.00976507932548303 109 1530061
SGTC_1457 k015-0032 57.3 µM 2.31840561937258 0.0120712969309046 no 108 0.0102136434735847 178 4302660
SGTC_2171 5739187 198.077 µM 2.31321065580555 0.0122311120325227 no 109 0.0103555299957216 106 2262761
SGTC_2697 mebhydrolin 72.4 µM 2.29782345056038 0.0127152795375032 no 110 0.0107859197537024 228 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2769 toremifene 3.73 µM 2.29022099164266 0.0129605564586995 no 111 0.0110042545772137 147 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2712 st079126 47.7 µM 2.28159347429897 0.0132438502562685 no 112 0.0112566761752645 139 3152970
SGTC_1554 st069299 38.7 µM 2.27619757661899 0.0134237364304279 no 113 0.0114170934521605 160 24207999
SGTC_2091 4-phenylthiadiazole 200 µM 2.27570455857322 0.0134402771567055 no 114 0.0114318491699654 158 270010
SGTC_1249 0481-0015 10.2 µM 2.25971104329457 0.0139864868918697 no 115 0.0119195952318326 148 4227577
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.25810429866313 0.0140424036579395 no 116 0.0119695788551488 153 6312947
SGTC_741 4582-0002 126 µM 2.25806104598153 0.0140439115658822 no 117 0.0119709268956039 157 2912688
SGTC_1145 3546-0597 10.2 µM 2.25415949869721 0.0141805055951763 no 118 0.0120930678538742 177 875334
SGTC_1075 aripiprazole 15.2 µM 2.24887997320153 0.0143671642958559 no 119 0.012260066739019 195 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1779 st039427 55 µM 2.23267440366423 0.0149533867024632 no 120 0.0127852117958571 198 1124498
SGTC_2451 5856223 45.7 µM 2.22157407160455 0.0153666969542525 no 121 0.0131560518745985 160 2179896
SGTC_301 4119-0100 24.5 µM 2.21999784234422 0.0154261744416058 no 122 0.0132094570399157 237 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_609 0986-0026 86.3 µM 2.21306115991989 0.0156902778655828 no 123 0.0134467146942261 200 2848610
SGTC_2812 7970281 58.44 µM 2.21248480708398 0.015712395116611 no 124 0.0134665924124658 194 2233435
SGTC_2867 9039098 71.43 µM 2.20544516733984 0.0159847032839485 no 125 0.0137114357568091 189 6463460
SGTC_753 1322-0200 289 µM 2.20378602017855 0.0160494685180283 no 126 0.0137696980983832 153 5403907
SGTC_1788 fluconazole 20 µM 2.18955366023192 0.0166143295549508 no 127 0.0142783114372119 207 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2878 9043973 25.97 µM 2.18357845295676 0.0168564991025405 no 128 0.01449661915092 135 6465167
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.18292511010211 0.0168831606515505 no 129 0.0145206627641686 245 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1667 st014849 34.6 µM 2.16396104934631 0.0176729099988238 no 130 0.0152336694402059 141 5348460
SGTC_309 k408-0051 1.48 µM 2.1576086831598 0.0179444053134422 no 131 0.0154791345128483 271 3640463
SGTC_2961 9083290 32.55 µM 2.14852485318794 0.0183388157648665 no 132 0.0158360421034628 159 17741490
SGTC_1127 asiatic acid 681.4 nM 2.14456494413877 0.0185130486223175 no 133 0.0159938238393479 194 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_300 r073-0011 5.04 µM 2.14420859870363 0.0185287964405676 no 134 0.0160080882084533 191 2735780
SGTC_1062 mesoridazine 14.2 µM 2.14268755308466 0.0185961436587219 no 135 0.016069097750005 194 4078 A neuroleptic.
SGTC_130 0136-0219 337.655 µM 2.13949227159068 0.0187382998338203 no 136 0.0161979105841489 184 234244
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.13563445326571 0.0189111632266785 no 137 0.0163546104381705 166 4330530
SGTC_914 3820-6779 408 µM 2.13551854516534 0.018916377826213 no 138 0.0163593385012216 184 2893481
SGTC_2598 perillyl alcohol 100 µM 2.11208809580213 0.0199959101118871 no 139 0.0173394469257174 226 10819 An apoptosis inducer.
SGTC_1371 2421-0008 32.7 µM 2.1029034220288 0.0204331188351326 no 140 0.017737106324216 238 2827552
SGTC_2017 5132927 60.65 µM 2.10240790177469 0.0204569351311724 no 141 0.017758779802509 215 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_770 0389-1121 67.2 µM 2.10056801515443 0.0205455719224849 no 142 0.0178394521096397 232 6753108
SGTC_1886 st057356 49.9 µM 2.09608057734156 0.0207631202987088 no 143 0.0180375218258446 183 24207747
SGTC_2481 5478948 45.16 µM 2.0855547918229 0.0212810684474251 no 144 0.0185094850298875 225 77792
SGTC_232 clozapine 119 µM 2.08168956309277 0.0214739902753509 no 145 0.0186854172832379 237 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_33 0986-0033 35.816 µM 2.07280504280861 0.0219230462709991 no 146 0.0190952134730579 162 2848082
SGTC_2317 5986382 200 µM 2.06891109636641 0.0221223454718435 no 147 0.019277215059564 162 877883
SGTC_1124 fisetin 1.16336 µM 2.06215956867464 0.022471524929966 no 148 0.0195962732970338 201 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2814 7977482 42.97 µM 2.04866474539707 0.0231833988396537 no 149 0.0202474544014275 279 6456762
SGTC_2556 citropten 84.59 µM 2.04793486305987 0.0232224365058568 no 150 0.0202831911250501 240 2775 A potential DNA crosslinker.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.04660687361101 0.0232936057921318 no 151 0.0203483497109802 271 91467 include heat shock
SGTC_2969 9091408 28.7 µM 2.02841247384534 0.0242873048026384 no 152 0.0212590840310945 242 4286311
SGTC_1151 3909-8316 15.3 µM 2.02674657558002 0.0243800418725262 no 153 0.0213441683045424 218 800431
SGTC_332 4112-0506 40.9 µM 2.01867100670191 0.0248338157303468 no 154 0.0217607126946669 193 2790355
SGTC_3079 9117512 49.47 µM 2.01052691774528 0.025298592508352 no 155 0.0221877251114373 115 7185044
SGTC_3142 9086498 49.47 µM 2.00340686646962 0.0257108781670215 no 156 0.0225668175269028 210 25236367
SGTC_2028 5153890 36.43 µM 1.99374405600128 0.0262793841717372 no 157 0.0230900160630735 225 2830968 YPR165W RHO1
SGTC_354 2783-3500 4.88 µM 1.99301500063923 0.0263227007891726 no 158 0.0231299022564068 264 6740761
SGTC_2956 9076196 2.52 µM 1.98970614742022 0.0265200461711041 no 159 0.0233116575607015 224 16423868
SGTC_3352 9151559 45.5865 µM 1.98767254573108 0.0266419457128392 no 160 0.0234239585923704 212 17159339
SGTC_65 0798-0905 34.986 µM 1.98634917529039 0.0267215232019831 no 161 0.0234972829407058 362 3602145
SGTC_2507 purpurin 79.67 µM 1.9858530413754 0.026751408059872 no 162 0.0235248220891166 263 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1531 st059297 52.4 µM 1.98107436183732 0.0270406857138339 no 163 0.023791467485125 218 7566702
SGTC_902 1120-0002 2.07 µM 1.973532654276 0.0275025318707199 no 164 0.0242174539969536 269 3280475
SGTC_1303 1160-0052 261 µM 1.96935443009844 0.0277612206053683 no 165 0.0244562024127235 218 3562476
SGTC_950 1165-0508 94.1 µM 1.96794249127868 0.0278490958129718 no 166 0.0245373275131631 231 6148369
SGTC_1111 tnp00062 510.699 nM 1.9652550312039 0.0280169963099351 no 167 0.0246923637386297 193 676306
SGTC_2805 7950783 58.44 µM 1.96316161133234 0.0281483671727091 no 168 0.0248136992019771 258 1178958 YDL195W SEC31
SGTC_1157 4092-0394 27.6 µM 1.96272403100486 0.0281758918744611 no 169 0.0248391246235942 263 3659885
SGTC_696 1560-0013 611 µM 1.95730940063519 0.02851834114272 no 170 0.0251555514667673 232 1650269
SGTC_3301 9125354 19.7965 µM 1.95165756483899 0.0288794786311297 no 171 0.0254894369498044 190 41905162
SGTC_2240 6690706 185.951 µM 1.94724302176508 0.029164193483397 no 172 0.0257528030634752 200 805876
SGTC_217 ketoconazole 989 nM 1.94340227739653 0.0294137945588279 no 173 0.0259837861629512 245 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1680 diphenhydramine 100 µM 1.94117859281205 0.0295591156371394 no 174 0.0261183093787956 247 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_791 1348-1292 225 µM 1.93932178717877 0.0296809167403428 no 175 0.026231083777659 313 5437054
SGTC_3022 9087993 49.47 µM 1.93435421163435 0.0300088243190035 no 176 0.0265347960436635 189 17173644
SGTC_1942 st076330 65.2 µM 1.93023322758494 0.0302831233283317 no 177 0.0267889731142825 248 24208414
SGTC_1472 k841-0093 193 µM 1.92865229464844 0.0303889026506074 no 178 0.0268870211465752 263 X1472
SGTC_2483 5729050 27.16 µM 1.92460224968958 0.0306612862589081 no 179 0.0271395688760062 306 2865180
SGTC_1060 3448-7350 82 µM 1.92436820847761 0.0306770881694114 no 180 0.0271542232226969 258 570178
SGTC_678 1218-2179 85.9 µM 1.92351472287892 0.0307347706504374 no 181 0.0272077196480566 148 6820081 YOR116C RPO31
SGTC_2936 9038235 15.59 µM 1.90446339946817 0.0320458985320802 no 182 0.0284249295207614 252 4749415
SGTC_2912 7964298 10.93 µM 1.89992064889979 0.0323652614480748 no 183 0.0287217668956083 347 2975850
SGTC_1321 1326-2144 215 µM 1.89820039535939 0.0324868816671805 no 184 0.0288348443839196 220 3513030
SGTC_1960 st011366 51.8 µM 1.89453707872763 0.0327471310059435 no 185 0.0290768787984095 192 3972846
SGTC_2189 6047310 154.431 µM 1.8937097290947 0.0328061449083682 no 186 0.0291317746171499 232 711535
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.88809977063656 0.0332086135057144 no 187 0.029506278829605 233 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2557 derrustone 83.84 µM 1.88679888706969 0.0333025198607202 no 188 0.0295936904423166 319 629853 An antioxidant.
SGTC_3121 9125696 49.47 µM 1.88386578317186 0.0335150532149671 no 189 0.0297915663029644 181 1235365
SGTC_3171 9103192 49.47 µM 1.87675831543519 0.0340346956959066 no 190 0.0302756130111347 192 13018434
SGTC_2291 7917025 104.35 µM 1.87391274972368 0.0342445901302426 no 191 0.0304712259308213 311 2964612
SGTC_3015 9080845 49.47 µM 1.87195241622686 0.0343898061973182 no 192 0.0306065934613113 241 5296973
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.86971540066707 0.0345561358976584 no 193 0.030761674862603 210 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_302 1094-0063 18.9 µM 1.86810451140565 0.0346763197993586 no 194 0.0308737524264808 194 5440289
SGTC_1769 st044406 64.4 µM 1.86792149565533 0.0346899957773816 no 195 0.0308865070954224 276 670903
SGTC_701 4424-0219 185 µM 1.86325290303823 0.0350403598966979 no 196 0.0312133464757838 265 2911779
SGTC_1046 2001-0062 216 µM 1.85778890898379 0.035454099347567 no 197 0.0315994983780068 267 739778
SGTC_60 0986-0278 202 µM 1.84237988516428 0.0366425054942346 no 198 0.0327098009857896 195 3110598
SGTC_1272 0839-0021 27 µM 1.84140291858925 0.0367189386487459 no 199 0.0327812677162676 272 5027250
SGTC_1760 st045453 10.4495 µM 1.84042924813272 0.0367952436213718 no 200 0.0328526213630818 355 3323419 YIL048W NEO1
SGTC_1014 4130-3005 69.3 µM 1.83605733438615 0.0371394632686352 no 201 0.0331745887582308 309 743608
SGTC_2199 6590217 200 µM 1.83025939106563 0.0376000148454899 no 202 0.0336055803215967 183 703109
SGTC_1791 st048313 56.1 µM 1.81714850048904 0.0386586648440026 no 203 0.034597189037614 232 1204976
SGTC_951 1171-0579 82.7 µM 1.81670318591645 0.0386950442866962 no 204 0.034631286830692 386 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2664 lyso-paf C-16 73.48 µM 1.816288028827 0.0387289851668957 no 205 0.0346631003175501 282 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2943 9068529 45.32 µM 1.81388678876763 0.0389257729881383 no 206 0.0348475785437924 297 3270634
SGTC_1781 st038725 66.3 µM 1.80957335454895 0.03928131473076 no 207 0.0351809875483397 391 4270275 YIL048W NEO1
SGTC_2996 9066192 71.4286 µM 1.80666676323966 0.0395223822113413 no 208 0.035407126466853 309 6472854
SGTC_2655 perillic acid 100 µM 1.8048272349118 0.0396755702102252 no 209 0.0355508605787156 187 5702197 An apoptosis inducer.
SGTC_1994 st072947 40.9 µM 1.79394274780987 0.04059189077974 no 210 0.0364111537194057 296 5286565 YDL195W SEC31
SGTC_1305 1181-0477 144 µM 1.79275377914822 0.040693017577923 no 211 0.0365061515580009 269 6252086
SGTC_2257 7960413 200 µM 1.78505962507509 0.0413523903395511 no 212 0.0371258230014661 323 2974689 YIL048W NEO1
SGTC_124 0136-0217 7.121 µM 1.78389931082712 0.0414525741057806 no 213 0.0372200139655584 343 3976905
SGTC_695 3505-6186 243 µM 1.78223145289154 0.0415969246271038 no 214 0.0373557478246705 276 1819379
SGTC_3243 9134147 49.47 µM 1.77974231633097 0.041813112660061 no 215 0.0375590708663266 213 24282180
SGTC_993 3909-8757 62.7 µM 1.7767575142001 0.0420735492534664 no 216 0.0378040724377893 244 4288324 YLR208W SEC13
SGTC_113 0099-0221 2.5 µM 1.77649436839124 0.042096572676478 no 217 0.0378257346612735 278 89219
SGTC_619 1652-1634 108 µM 1.77235356474038 0.0424602085879705 no 218 0.0381679423951922 260 5400454
SGTC_2040 5100729 123 µM 1.77213658747581 0.0424793328667407 no 219 0.038185943402945 317 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_910 3454-3003 490 µM 1.77130800587413 0.0425524277822729 no 220 0.0382547484365416 327 820824
SGTC_815 1582-0027 36.9 µM 1.76460877737528 0.0431471554390838 no 221 0.0388147696442014 292 3128206
SGTC_858 0438-0351 2.77 µM 1.76393206475648 0.0432076024965153 no 222 0.0388717087933273 315 2799119
SGTC_40 0327-0103 19.753 µM 1.7618998449185 0.0433895408285393 no 223 0.039043110418597 302 409036
SGTC_2019 4016004 108 µM 1.76014536748541 0.0435471107848784 no 224 0.0391915811374186 263 45595336
SGTC_2572 astragaloside iv 100 µM 1.75457860997953 0.0440501218859848 no 225 0.0396657064273572 309 45006101 An anti-inflammatory agent.
SGTC_1059 3448-6867 171 µM 1.75260424488436 0.0442296466369934 no 226 0.0398349810719029 297 3934407
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.75168816089085 0.0443131442420926 no 227 0.0399137218712717 185 279621
SGTC_673 1082-0474 110 µM 1.75154573809371 0.0443261369467374 no 228 0.0399259749910227 403 3098046
SGTC_1998 st075797 76.8 µM 1.74595162892871 0.0448389000290057 no 229 0.0404096787057438 339 24208315
SGTC_1483 3453-0561 55.9 µM 1.74155431694145 0.0452453066728188 no 230 0.0407932304802219 336 4546991
SGTC_658 3253-0951 102 µM 1.73409665522433 0.0459413260601012 no 231 0.0414504674507671 414 1184878
SGTC_730 1436-0052 41.2 µM 1.73376053703609 0.0459728972627085 no 232 0.041480290159366 253 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2833 9001315 45.46 µM 1.7293662882046 0.0463872497532759 no 233 0.0418717797903655 361 2989378
SGTC_1958 st076513 41.9 µM 1.72791134880109 0.0465251010161929 no 234 0.0420020596745464 344 732122 YGL099W LSG1
SGTC_2922 7999257 32.47 µM 1.72513243703872 0.0467893083892667 no 235 0.0422518040404846 262 2988377
SGTC_1957 st077035 62.4 µM 1.71973966625863 0.0473054640821525 no 236 0.0427398870365202 281 705593
SGTC_447 ml7 120 µM 1.71899381373022 0.0473772093493425 no 237 0.0428077491848014 314 4216 Selective myosin light chain kinase inhibitor.
SGTC_3290 9121031 71.43 µM 1.71347603707316 0.0479106891410503 no 238 0.0433124990821345 268 17014854
SGTC_2981 9013952 38.96 µM 1.71144205801694 0.0481085508853152 no 239 0.0434997693928342 324 2996344
SGTC_1801 st050089 28.441 µM 1.71048876054532 0.0482015106929209 no 240 0.0435877650287292 448 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2337 9009472 200 µM 1.70802646807939 0.0484422836587174 no 241 0.0438157156991811 365 5742383
SGTC_3134 9127454 49.47 µM 1.69991967008588 0.0492418019810008 no 242 0.0445730182287227 285 24262820
SGTC_1372 2752-0194 270 µM 1.69959955368836 0.0492735878568701 no 243 0.0446031371858275 305 823334
SGTC_1024 4507-0395 26 µM 1.69445808105256 0.0497863571928752 no 244 0.0450891354034016 318 4201836
SGTC_2222 6885208 172.143 µM 1.6902521795362 0.0502089779458142 no 245 0.0454898597749285 234 609514
SGTC_1506 4226-2149 212 µM 1.68706736723844 0.0505308954209976 no 246 0.0457951994871249 387 991114
SGTC_2939 9044578 71.43 µM 1.68506239345949 0.0507343980277984 no 247 0.0459882671373738 345 2653634
SGTC_1130 3454-2858 15.9 µM 1.68130082745784 0.0511179532228571 no 248 0.0463522486293392 376 715628 YIL048W NEO1
SGTC_1876 myriocin 605 nM 1.68002473853039 0.0512485949982645 no 249 0.0464762512933538 312 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_89 0302-0250 142.109 µM 1.67744914957646 0.0515130843533536 no 250 0.0467273425919927 362 4203518 YLR208W SEC13
SGTC_870 0573-2213 57.6 µM 1.67721108759301 0.0515375858363076 no 251 0.0467506058308258 292 3916321
SGTC_2521 angolensin 13.4 µM 1.67265473709105 0.052008316507485 no 252 0.0471976422882951 296 821428 A flavenoid.
SGTC_755 1995-0008 37.3 µM 1.67262084672125 0.0520118305819557 no 253 0.0472009801612781 318 689533
SGTC_3295 9122362 53.5725 µM 1.67141444093863 0.0521370450801047 no 254 0.0473199227424591 314 4730473
SGTC_3172 9105863 49.47 µM 1.66549764946209 0.0527546274127845 no 255 0.0479067560945942 202 2348785
SGTC_2203 7227154 166.4 µM 1.66446530315939 0.0528629738636726 no 256 0.0480097396523081 297 896304
SGTC_2601 securinine 100 µM 1.66341946208561 0.0529729165273616 no 257 0.0481142500030885 337 442872 A GABA receptor antagonist.
SGTC_2776 terbinafine 19.92 µM 1.66314242666239 0.0530020698708843 no 258 0.048141964485357 349 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_197 4544-0043 41.561 µM 1.6599523901707 0.0533386854153623 no 259 0.0484620153557961 403 896523
SGTC_3323 9138564 53.9225 µM 1.65822603759634 0.0535215570259693 no 260 0.04863592559473 391 43912313 YNL103W MET4
SGTC_1162 k048-0130 20.1 µM 1.64993689086853 0.0544065504332563 no 261 0.0494779222202447 337 6797406
SGTC_2216 7189485 200 µM 1.64755852651668 0.0546626030579056 no 262 0.0497216484659521 275 731273
SGTC_1622 st003707 19.4 µM 1.64383570015033 0.0550653111409358 no 263 0.0501050724533432 402 10140899
SGTC_2974 9094440 9.66 µM 1.63986684749441 0.0554972102712277 no 264 0.0505164276659138 410 25236134
SGTC_1655 st012546 55.1 µM 1.63968538696066 0.0555170209505336 no 265 0.0505352994291632 317 720985 YLR208W SEC13
SGTC_3102 9121669 49.47 µM 1.63900485562676 0.0555913666617994 no 266 0.0506061242242475 278 41905072
SGTC_1505 k297-0037 20.6 µM 1.63505343658908 0.0560245996487823 no 267 0.0510189230586336 365 4089396
SGTC_2702 st077768 96.8 µM 1.63391253540193 0.0561501820667854 no 268 0.0511386086204852 335 6484119
SGTC_385 1494-0393 12.4 µM 1.63383819882104 0.0561583722137733 no 269 0.0511464146018425 359 3090647
SGTC_723 4182-0001 115 µM 1.63367247325082 0.0561766346740172 no 270 0.0511638206275027 340 744821 YLR208W SEC13
SGTC_1190 1486-1332 13 µM 1.62886437383925 0.0567085143255888 no 271 0.0516708667060814 335 4150046
SGTC_1147 3809-1045 12.3 µM 1.62865228307201 0.0567320671857542 no 272 0.0516933247522522 364 325925
SGTC_1932 st074806 40.9 µM 1.628013916556 0.0568030048327093 no 273 0.0517609674730398 389 17251235
SGTC_841 0251-0215 91.2 µM 1.6261553060864 0.0570099383459147 no 274 0.0519583105982294 427 3888614
SGTC_859 0439-0102 54.6 µM 1.62404835552948 0.0572452387663116 no 275 0.0521827443873013 379 610143
SGTC_3274 9138298 49.47 µM 1.62071930008168 0.0576185787007286 no 276 0.0525389262574257 386 17015756
SGTC_1849 st056239 19.2 µM 1.61999509844416 0.05770004798638 no 277 0.0526166649132173 384 5393181
SGTC_2193 5925765 200 µM 1.61615104947054 0.0581340028819768 no 278 0.0530308296199432 284 877370
SGTC_1097 itavastatin 7.23 µM 1.61082256636104 0.0587397717352177 no 279 0.0536092005473409 375 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2881 9058953 51.95 µM 1.60960292123656 0.0588791215163491 no 280 0.0537422850439327 398 17122249
SGTC_1006 4099-6547 255 µM 1.60615578959292 0.0592743742360396 no 281 0.0541198422126273 364 3146833
SGTC_1661 st013063 9.66 µM 1.60572753594662 0.0593236233231802 no 282 0.0541668941865245 403 721395
SGTC_2395 5646831 180.19 µM 1.60460998785704 0.0594522922431317 no 283 0.0542898310022985 370 6808628
SGTC_3242 9133940 49.47 µM 1.60217387853418 0.0597335318662421 no 284 0.0545585823288293 341 17248444
SGTC_2016 5121758 140 µM 1.60160186181073 0.0597997199096818 no 285 0.0546218394267621 422 2795203
SGTC_2889 9059656 51.95 µM 1.60062301115545 0.0599131159625133 no 286 0.0547302212177139 388 3949838
SGTC_888 0916-0002 6.97 µM 1.59916163197843 0.0600827244031255 no 287 0.0548923465668087 349 2802138 YIL048W NEO1
SGTC_469 w7 172 µM 1.58728952482907 0.0614745747735294 no 288 0.056223543305435 266 45115570 A P450 inhibitor.
SGTC_3115 9123671 49.47 µM 1.58394292751968 0.061871435749348 no 289 0.0566033536918683 334 3286988
SGTC_1750 st081859 2.357 µM 1.58309011159596 0.0619728871656538 no 290 0.0567004635556753 601 5291695
SGTC_821 1114-0266 29.2 µM 1.58185159129455 0.0621204532720579 no 291 0.0568417270931304 359 3123235
SGTC_1252 0493-0875 34.8 µM 1.58121016691888 0.0621969848016474 no 292 0.056914995743067 380 3960963
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.57919507912141 0.0624378934704654 no 293 0.0571456591651096 655 16725076
SGTC_2893 9048488 25.97 µM 1.5721964376766 0.0632802530397744 no 294 0.0579525006803273 366 6467338
SGTC_313 3474-0040 5.03 µM 1.57218651269442 0.0632814538664876 no 295 0.057953651211219 458 1043375 YIL048W NEO1
SGTC_2289 7946404 165.07 µM 1.57209673217008 0.0632923172464662 no 296 0.0579640596292046 495 1246120 YPR165W RHO1
SGTC_510 ag-490 170 µM 1.56700363949913 0.0639109584846453 no 297 0.0585569204560425 356 5328779
SGTC_1775 st081588 35.1725 µM 1.56520746838946 0.0641302516779753 no 298 0.0587671354685486 420 1426443 YGL099W LSG1
SGTC_3256 9138902 49.47 µM 1.56505358594682 0.0641490662408702 no 299 0.0587851726206452 316 17228773
SGTC_828 2074-0507 139 µM 1.56446084949859 0.0642215777464645 no 300 0.0588546901384072 417 X828
SGTC_2236 dapsone 200 µM 1.5639957295099 0.0642785220847522 no 301 0.0589092856580459 393 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_171 k064-0041 9.68 µM 1.5633278716059 0.0643603561107434 no 302 0.0589877479233716 307 53325
SGTC_1787 fluconazole 80 µM 1.56152045459391 0.0645822287305586 no 303 0.0592005007535236 475 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_848 0368-0089 85.6 µM 1.5580281386049 0.0650126166116075 no 304 0.0596132889702744 399 762535
SGTC_586 0957-0265 8.15 µM 1.55765648528133 0.0650585493751736 no 305 0.0596573504812525 310 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2333 9017922 200 µM 1.55481834936717 0.0654101465849689 no 306 0.0599946688645371 390 3163164
SGTC_2081 5214970 32.255 µM 1.55264362246549 0.0656805545315387 no 307 0.0602541489947973 373 2063512
SGTC_2293 7624732 200 µM 1.55043294054533 0.0659563206062431 no 308 0.0605188186705728 367 894453
SGTC_1709 st033179 39.1045 µM 1.54993492793861 0.0660185676106408 no 309 0.0605785676289539 420 573381
SGTC_32 0928-0142 34.1 µM 1.54822518064049 0.0662326167415284 no 310 0.0607840454270578 339 2244242
SGTC_1056 3448-1962 115 µM 1.54634603456547 0.0664684930932101 no 311 0.061010509889382 369 715507
SGTC_1715 st032160 10.2275 µM 1.53960881248185 0.0673195188334316 no 312 0.0618278680456998 388 5289825
SGTC_3063 1327-0034 4 µM 1.53806459019117 0.0675157618444724 no 313 0.0620164114226572 383 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1375 2910-0797 186 µM 1.53782178554953 0.0675466581464032 no 314 0.0620460976740247 405 742508
SGTC_1579 chlormadinone acetate 49.4 µM 1.53505260977065 0.0678998023283835 no 315 0.0623854528489359 404 45114258 A steroidal progestin.
SGTC_2274 7947094 46.08 µM 1.52964480983098 0.068593550728467 no 316 0.0630523357359955 431 2971028
SGTC_2142 5622915 118.518 µM 1.52802712370842 0.0688021370092558 no 317 0.063252901861175 365 5322196
SGTC_2558 carylophyllene oxide 100 µM 1.52772477557192 0.0688411763075426 no 318 0.0632904430288862 412 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3212 9128307 49.47 µM 1.52671704348639 0.0689714183576537 no 319 0.0634156937246638 386 27243542
SGTC_1719 st032227 49.2 µM 1.52084690982864 0.0697338691204975 no 320 0.0641491296879003 412 3125804
SGTC_863 0466-0191 129 µM 1.51955538918718 0.0699024876520328 no 321 0.064311378556989 470 765160 YPR165W RHO1
SGTC_697 0508-1955 564 µM 1.51816067501014 0.070084931114064 no 322 0.0644869492013949 451 6243113
SGTC_1997 st073024 93.8 µM 1.51042578392875 0.071103393089367 no 323 0.0654674067798491 393 686268
SGTC_2075 5212009 200 µM 1.4945007080545 0.0732360079365765 no 324 0.0675223984953873 373 780898
SGTC_752 1896-0090 130 µM 1.49324796695283 0.0734058236042087 no 325 0.0676861451738294 424 772567
SGTC_689 0833-0039 98 µM 1.48463318204422 0.0745817698556454 no 326 0.0688205102785125 430 5374726
SGTC_308 4092-1169 104 µM 1.48355050884853 0.0747305696628388 no 327 0.0689641036743777 469 2268590 YDL196W YDL196W
SGTC_78 0336-0123 156.75 µM 1.48329348186599 0.0747659280380906 no 328 0.0689982266910312 385 6765896
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.4827761116493 0.0748371397004547 no 329 0.0690669524502134 468 5106787 A p450 inhibitor.
SGTC_3097 9117246 49.47 µM 1.48225136106867 0.0749094200546835 no 330 0.0691367124695284 432 16423892
SGTC_1927 st060202 13.8 µM 1.47170260206754 0.0763737504959618 no 331 0.0705506023202054 418 688887
SGTC_2606 farnesol 9.78 µM 1.46961857901502 0.076665604406176 no 332 0.0708325427637204 450 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_600 1495-0418 41.6 µM 1.46947159534793 0.076686220491122 no 333 0.0708524603198137 424 5377768
SGTC_341 1486-1430 230 µM 1.46921364394561 0.0767224112195534 no 334 0.0708874253633796 427 2054753 YPL210C SRP72
SGTC_1992 st073643 23.3 µM 1.46245305896604 0.0776755624942932 no 335 0.0718085493490649 418 3161292
SGTC_2195 6536160 144.242 µM 1.46242910309645 0.0776789558594209 no 336 0.0718118295604919 386 3834386
SGTC_375 3970-0961 9.27 µM 1.46192798089764 0.0777499659603673 no 337 0.0718804731957849 453 2898222
SGTC_1717 st033143 58.0435 µM 1.46166714531914 0.0777869464195344 no 338 0.0719162223157924 500 674616
SGTC_1804 st050076 49.1 µM 1.45906182747681 0.0781570532528267 no 339 0.0722740457018806 449 3895976
SGTC_1653 st012112 65 µM 1.45723258319448 0.0784177095474755 no 340 0.0725260946198675 418 720429
SGTC_1921 5740136 50 µM 1.45427015023756 0.0788412356260689 no 341 0.0729357113876343 493 1774243
SGTC_676 falcarinol 140 µM 1.45323871635219 0.0789891012340239 no 342 0.0730787430148045 478 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1267 0828-0272 9.49 µM 1.45301752164137 0.0790208388815864 no 343 0.0731094445961234 493 745334
SGTC_1346 1488-2224 62.4 µM 1.45158761431469 0.0792262391256878 no 344 0.0733081523360147 447 3722427
SGTC_445 e6 berbamine 66 µM 1.45041120144201 0.0793955288200522 no 345 0.0734719426503708 595 6610268 A calcium/calmodulin antagonist.
SGTC_3050 9093513 49.47 µM 1.44579298320474 0.0800627534850056 no 346 0.0741176373904496 436 25236664
SGTC_1492 4158-0558 28.5 µM 1.444537142826 0.0802449241469104 no 347 0.0742939697746563 421 3967268
SGTC_1575 cyproterone acetate 48 µM 1.44311098050237 0.0804521811847412 no 348 0.0744946053138127 454 9880 An androgen receptor antagonist and liver toxin.
SGTC_1638 st008370 60.6 µM 1.44200206531091 0.0806136135716459 no 349 0.0746508954883708 476 24207134
SGTC_2251 lansoprazole 556 µM 1.44134164524017 0.0807098716215877 no 350 0.0747440937174877 344 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1380 2291-0730 164 µM 1.43508251904511 0.0816264701597026 no 351 0.075631792150792 428 2999191
SGTC_2585 alliin 100 µM 1.43499216894943 0.0816397584278197 no 352 0.0756446645761431 494 87310 A garlic compound which reacts with lipids.
SGTC_1345 1488-0192 31.4 µM 1.43012030626882 0.0823587066240191 no 353 0.0763412465247358 469 658348
SGTC_1398 3558-0053 112 µM 1.42510241146244 0.0831041783359234 no 354 0.0770637998496288 380 4532369
SGTC_1689 st020265 53.493 µM 1.41718393610331 0.0842908733481353 no 355 0.0782145785599703 448 5758320 YPR016C TIF6
SGTC_932 2857-0803 154 µM 1.41601495077621 0.0844671341964801 no 356 0.0783855635785923 500 674898
SGTC_2544 sphondin 68.51 µM 1.41231076961188 0.0850274809673609 no 357 0.0789292383633052 432 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2903 5923464 63.88 µM 1.41025303985138 0.0853399636168509 no 358 0.079232489692357 437 2876576
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.40812444188622 0.0856641125788197 no 359 0.0795471123501112 470 390807
SGTC_539 4859-0462 2.54 µM 1.40779684613246 0.0857140815357468 no 360 0.0795956172719444 459 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1695 st026914 34.495 µM 1.40275147094552 0.0864864227788838 no 361 0.080345481430716 478 3289191
SGTC_150 3970-0969 77.2 µM 1.40189884795716 0.0866174538097385 no 362 0.0804727272799966 568 6615640
SGTC_2388 9080168 200 µM 1.39839692495676 0.0871571855775845 no 363 0.0809969530397976 430 15943073
SGTC_2445 5742597 35.57 µM 1.39790728267637 0.0872328510886524 no 364 0.081070455722736 466 1774255
SGTC_1042 0350-0096 82 µM 1.39666993504225 0.0874242797341788 no 365 0.0812564245682133 467 3122515
SGTC_3184 9108758 49.47 µM 1.39420863533373 0.0878059965100357 no 366 0.0816273055223491 451 902885
SGTC_2071 5230951 39.92 µM 1.39163358296652 0.0882066841559685 no 367 0.0820166919617858 507 1799272
SGTC_1408 3909-7976 48.8 µM 1.38741391584758 0.0888662240555791 no 368 0.0826577920280832 533 24152374
SGTC_277 nystatin 15.5 µM 1.3841567955681 0.089377822176641 no 369 0.0831552246338966 504 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3041 9091929 49.47 µM 1.38412822157681 0.0893823199871585 no 370 0.083159598437995 501 25236887
SGTC_2427 5545055 42.75 µM 1.38393231835708 0.0894131615003085 no 371 0.0831895898878014 531 5372858
SGTC_2009 4012297 12.05 µM 1.38310974175605 0.0895427481070467 no 372 0.0833156095422548 480 45595307
SGTC_1797 st048695 56.8 µM 1.38202945569476 0.0897131456901692 no 373 0.0834813284986968 505 592262 YIL048W NEO1
SGTC_3312 9133330 71.43 µM 1.38165985407217 0.0897714996577878 no 374 0.0835380832784045 506 17617324
SGTC_1548 st061468 90.8 µM 1.38006079679644 0.0900242894158226 no 375 0.0837839632449876 484 390799
SGTC_1523 st012844 44.7 µM 1.3791416082011 0.090169840150987 no 376 0.0839255486464496 498 4274103
SGTC_379 3970-0972 5.9 µM 1.37267272559158 0.0911991155338756 no 377 0.0849270559296179 494 2898042 YBL034C STU1
SGTC_17 0960-0276 49.807 µM 1.37189434811338 0.0913235494210823 no 378 0.0850481650588146 538 6821114
SGTC_120 rhodamine 6G 52.259 µM 1.37139768187619 0.0914030138115482 no 379 0.0851255098571384 595 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_448 monastrol 171 µM 1.36888422273004 0.0918059422411011 no 380 0.085517734134521 488 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3087 9117406 49.47 µM 1.36370397056868 0.092640527392939 no 381 0.086330376949091 479 42546093
SGTC_1266 0828-0227 32.9 µM 1.36348587504133 0.0926757872452508 no 382 0.0863647165446352 474 3913820
SGTC_2600 tangeritin 87.95 µM 1.36063106137325 0.0931382452086953 no 383 0.0868151552355724 478 68077 A bioactive flavone.
SGTC_1328 1441-0025 69.2 µM 1.35879398897112 0.0934367373713856 no 384 0.0871059393183797 452 4562601
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.35643804990654 0.0938205696745449 no 385 0.0874799168479217 455 364106
SGTC_213 1246-0773 967 nM 1.35454640029975 0.0941296008620546 no 386 0.0877810602411239 535 6251622
SGTC_1159 4092-0538 61.2 µM 1.35443889668443 0.0941471858200667 no 387 0.0877981975994452 550 717301
SGTC_2029 5175081 200 µM 1.35354093691536 0.0942941647179142 no 388 0.0879414405887481 554 1380876
SGTC_2654 protoveratrine a 100 µM 1.35227809587894 0.0945011539833511 no 389 0.0881431844127846 488 5702278 A heart drug and vasodilator.
SGTC_1999 st074831 12.5 µM 1.34674255289998 0.0954124249531107 no 390 0.0890315811300764 532 17112523
SGTC_760 0568-0725 82.9 µM 1.34042610618883 0.0964601322844545 no 391 0.0900534265224756 523 3916171
SGTC_1391 3442-0225 151 µM 1.33651732353984 0.0971127010814541 no 392 0.0906901210337877 455 5227075
SGTC_1473 k844-0725 134 µM 1.33600364793902 0.0971986992046946 no 393 0.0907740404805769 583 54682906
SGTC_1666 st014829 29 µM 1.33464724884243 0.0974260523128701 no 394 0.0909959130586589 545 3858230
SGTC_1291 0993-0025 5.79 µM 1.33428001611168 0.097487673150395 no 395 0.091056052186108 518 4353356
SGTC_3282 9108498 15.4605 µM 1.32993870574578 0.0982183029208708 no 396 0.0917692336598648 538 16459645
SGTC_11 0438-0307 1.3 µM 1.32982247615773 0.0982379190010846 no 397 0.091788384330143 495 4011476
SGTC_476 mead acid 10 µM 1.32843603838639 0.0984721295647652 no 398 0.0920170502833909 454 5312531 An omega 9 fatty acid.
SGTC_558 k064-0027 21.3 µM 1.32714945427397 0.0986898373718619 no 399 0.0922296244062964 534 5088526
SGTC_1431 4049-0260 9.09 µM 1.32635381114569 0.0988246473546996 no 400 0.0923612652447589 513 3854841
SGTC_2728 chlorpromazine 9.18 µM 1.32267019656125 0.0994505377311834 no 401 0.0929725394516176 419 2726 A thorazine and dopamine antagonist.
SGTC_1947 st076332 61.6 µM 1.31888638066749 0.100096465150328 no 402 0.0936035499765595 448 24208416
SGTC_1833 st055984 71 µM 1.31871860046363 0.100125177318565 no 403 0.0936316029961246 504 676288
SGTC_3035 9091303 49.47 µM 1.31846390037773 0.100168775547674 no 404 0.0936742009723289 488 25237002
SGTC_2950 9072895 21.46 µM 1.31818977229436 0.100215714842976 no 405 0.0937200642203717 559 17332245
SGTC_256 clotrimazole 625 nM 1.31609758765476 0.100574491231785 no 406 0.0940706452788865 527 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2381 9035592 200 µM 1.31350610517501 0.1010201872074 no 407 0.0945062325198802 455 4749657
SGTC_2135 5326629 150.42 µM 1.31304485217049 0.10109966647975 no 408 0.094583917500649 500 5020077
SGTC_681 1642-0006 26.6 µM 1.31282676867798 0.101137260673213 no 409 0.0946206638627283 476 4446530
SGTC_3331 9141060 1.957 µM 1.31219879813428 0.101245569906067 no 410 0.0947265336414015 502 4906567 YPR165W RHO1
SGTC_1148 3909-7663 27.7 µM 1.31163934539536 0.101342132694009 no 411 0.094820925488575 540 4084526
SGTC_897 1000-0139 31.4 µM 1.3107907369318 0.101488732449738 no 412 0.0949642364683175 522 6151020
SGTC_919 tnp00227 403.569 nM 1.31009622492348 0.101608826447402 no 413 0.095081642686938 586 1269246 A methoxyflavone. YNL221C POP1
SGTC_1055 3448-0672 86 µM 1.30622576651608 0.102279996068317 no 414 0.0957378964485964 530 748378
SGTC_1363 1636-0063 10.4 µM 1.30608798646855 0.102303947566888 no 415 0.0957613189493143 574 6072185
SGTC_123 0083-0120 66.675 µM 1.30487968805985 0.102514171313256 no 416 0.0959669093534541 567 16001701
SGTC_2379 9035213 200 µM 1.30273071416017 0.10288883256613 no 417 0.0963333561525683 593 646551
SGTC_1914 st062367 72.6 µM 1.30077178273006 0.103231226893079 no 418 0.0966682916057775 523 978205
SGTC_444 curcumin 90.4 µM 1.30062725178326 0.103256521653016 no 419 0.0966930371514405 570 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_483 fpl-64176 144 µM 1.29992994331285 0.103378622766558 no 420 0.0968124906481514 465 3423
SGTC_1101 ebselen 5.29 µM 1.29826733227131 0.103670174494307 no 421 0.0970977439240101 579 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3354 9151612 71.43 µM 1.297856652135 0.103742282230314 no 422 0.0971682990023707 588 27261949
SGTC_925 2064-1272 59.6 µM 1.29320380190388 0.104561778014935 no 423 0.0979702905413509 532 6815817
SGTC_249 wiskostatin 11.211 µM 1.29215282940041 0.104747530881295 no 424 0.0981521117968924 551 2775510 A n-wasp and actin depolymerizer.
SGTC_1511 0906-3109 28.5 µM 1.29119042580841 0.104917839249483 no 425 0.0983188271011617 648 2882180
SGTC_1335 1486-0900 202 µM 1.28940001469573 0.105235206259502 no 426 0.0986295281593612 586 X1335
SGTC_3130 9127414 49.47 µM 1.28884885542654 0.105333044050304 no 427 0.098725318743435 527 1494646
SGTC_1615 st002656 86.5 µM 1.28348361009726 0.106288883076057 no 428 0.0996613490399986 549 1584458
SGTC_2626 ethyl orsellinate 100 µM 1.28243747246243 0.106475984028783 no 429 0.0998446130588435 540 75653 A natural product.
SGTC_1422 4031-0024 15.5 µM 1.27837274470293 0.107205214394304 no 430 0.100559014705034 558 782427
SGTC_1596 piperlongumine 63 µM 1.27749311455399 0.107363496854059 no 431 0.100714104882015 623 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3258 9138477 49.47 µM 1.27194307067818 0.108366068807858 no 432 0.10169667359018 556 4970355
SGTC_408 cantharidin 100 µM 1.26997409654385 0.108723362500242 no 433 0.102046928655692 592 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2706 st078239 82.5 µM 1.26932136890478 0.10884199442976 no 434 0.102163233969097 566 15434492
SGTC_724 3910-0327 137 µM 1.26822117741518 0.109042162595511 no 435 0.102359488167749 582 2885483
SGTC_2272 7805186 180 µM 1.26683030758996 0.109295595090684 no 436 0.102607986309014 552 2956062 YPR165W RHO1
SGTC_1867 st057372 64 µM 1.26460428093388 0.109702082870226 no 437 0.10300660885266 575 688837
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.26421162907016 0.109773896258883 no 438 0.103077038979424 533 2374 Ca(2+)-ATPase inhibitor.
SGTC_3279 9140807 49.47 µM 1.26294316930718 0.110006119598898 no 439 0.10330480212261 561 45595718
SGTC_3325 9138760 55.175 µM 1.26270688421026 0.110049416422437 no 440 0.103347269536839 571 43844959
SGTC_1307 1187-1599 12.2 µM 1.25689162045078 0.111118859553052 no 441 0.104396441618366 575 1538471
SGTC_1665 st014639 11.4 µM 1.2561994372624 0.111246647902501 no 442 0.104521835368685 627 981133 YIL048W NEO1
SGTC_1494 4358-1428 177 µM 1.25300701068357 0.111837383756728 no 443 0.105101577657622 597 1564571
SGTC_2689 tacrolimus 100 µM 1.25159011520482 0.112100287769538 no 444 0.105359629148892 557 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2897 9048598 12.99 µM 1.2503904323119 0.112323233286837 no 445 0.105578478962754 556 6467404
SGTC_2489 cantharidin 73.42 µM 1.24961597082034 0.11246732510007 no 446 0.10571993308175 588 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2414 st077232 92.9 µM 1.2480950997058 0.112750673736077 no 447 0.105998116311974 565 729801
SGTC_538 2922-0838 53.3 µM 1.24709839008968 0.112936643783946 no 448 0.106180711595955 664 777039
SGTC_1129 3453-1384 223 µM 1.2466794149943 0.113014883151534 no 449 0.106257534819407 638 1084452
SGTC_339 3091-4833 71.4 µM 1.2435381956578 0.113602706541652 no 450 0.106834787476786 580 3240077
SGTC_830 4076-0286 57.8 µM 1.24118619172894 0.114044267124294 no 451 0.107268487307867 739 6866659
SGTC_1637 st007924 17.4 µM 1.24094275165323 0.114090039812704 no 452 0.107313449041902 587 683336
SGTC_996 3970-0799 1.8 µM 1.23984376628744 0.114296838826907 no 453 0.107516593311405 766 6615648 YGL040C HEM2
SGTC_1281 0884-0031 11.8 µM 1.23745056482326 0.11474809709983 no 454 0.107959928211791 612 1548255
SGTC_774 k060-0086 136 µM 1.23254586510653 0.115676877235559 no 455 0.108872622378316 674 5911235
SGTC_1011 4112-3381 17.4 µM 1.2299793732494 0.116165004472539 no 456 0.109352414532959 605 2877139
SGTC_1144 3486-0183 12.5 µM 1.22887171231078 0.116376124128504 no 457 0.109559954455451 650 6744069
SGTC_1877 wortmannin 25 µM 1.22590086114043 0.116943710655002 no 458 0.110117992357399 662 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1904 st060225 78 µM 1.2235725228704 0.117389913190873 no 459 0.110556765140465 588 66595
SGTC_3257 9139206 32.98 µM 1.2224964239287 0.117596543554743 no 460 0.110759977699264 537 4910041
SGTC_380 3970-0968 6 µM 1.21862145746953 0.118342739251551 no 461 0.111493950517389 582 2891601
SGTC_1710 st031758 61.5 µM 1.2177526578514 0.11851050089453 no 462 0.111658989901655 572 5394341
SGTC_1362 1611-0397 101 µM 1.21679533876615 0.118695549837435 no 463 0.111841046979056 603 27816
SGTC_3163 9099914 49.47 µM 1.21582880754782 0.118882586479199 no 464 0.11202507123125 547 16268368
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.21459206571365 0.11912221591487 no 465 0.112260858251727 657 1377
SGTC_2428 5615643 7.78 µM 1.21301271717465 0.119428723858026 no 466 0.112562479207931 583 2253075
SGTC_3070 9117005 49.47 µM 1.21210337107942 0.119605455051088 no 467 0.112736406742131 531 8779016
SGTC_2138 5575593 77.673 µM 1.21032265219276 0.1199520714587 no 468 0.113077554427822 570 762213
SGTC_1550 gossypolone 36.6 µM 1.20853141530168 0.120301448946961 no 469 0.113421459722906 630 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2218 6965428 192.983 µM 1.20804137764242 0.120397154660395 no 470 0.113515673432419 616 675684
SGTC_1453 4237-0541 195 µM 1.2068818741329 0.120623822443862 no 471 0.113738819571026 627 739892
SGTC_757 1066-0008 322 µM 1.19872673865801 0.122226534029083 no 472 0.11531710873604 655 6842497
SGTC_2875 9039966 71.43 µM 1.19861634373966 0.122248331780811 no 473 0.115338580072087 566 6463691
SGTC_2895 9054447 58.44 µM 1.19841670272555 0.122287758326215 no 474 0.115377416604611 586 2697450
SGTC_117 lucigenin 22.078 µM 1.19520907941227 0.122922446906645 no 475 0.116002676030527 678 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3123 9126162 49.47 µM 1.19461740831506 0.123039772014745 no 476 0.116118272283769 609 25239884
SGTC_2241 6772625 37.8075 µM 1.19350049949254 0.123261462770778 no 477 0.116336708327326 596 2285411
SGTC_1988 st071872 53.4 µM 1.1929687070296 0.123367114426218 no 478 0.116440814406209 619 16414116
SGTC_172 1112-0046 2.638 µM 1.18924892507351 0.124107900669552 no 479 0.117170863609741 557 2802135 YIL048W NEO1
SGTC_482 fipronil 114 µM 1.18847128918331 0.124263157616917 no 480 0.11732389234367 565 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1706 st031321 9.9705 µM 1.18713823380819 0.124529621397399 no 481 0.117586549680938 634 6103185
SGTC_3259 9138485 49.47 µM 1.18580694776724 0.124796129925521 no 482 0.117849273560921 690 17646153
SGTC_2167 5876490 200 µM 1.18043567694264 0.125875444919369 no 483 0.118913489649045 642 686534
SGTC_1991 st073000 8.92 µM 1.17752210928222 0.126463619339438 no 484 0.119493589124895 691 4301969 YIL048W NEO1
SGTC_2818 7996756 12.99 µM 1.17723579131372 0.126521522732296 no 485 0.11955070338605 551 2241621
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.17598597616314 0.126774494815293 no 486 0.119800240047924 651 4213774
SGTC_2338 7999974 200 µM 1.17309753447792 0.127360484215889 no 487 0.120378347559555 700 315925
SGTC_2465 5809242 33.21 µM 1.17249217395537 0.127483534472429 no 488 0.120499756166446 624 2731748
SGTC_1038 k292-0204 154 µM 1.16726234446801 0.128550032552288 no 489 0.121552220249695 599 4454212
SGTC_3170 9103054 49.47 µM 1.1672417517125 0.128554244152736 no 490 0.121556377118644 603 16432970
SGTC_653 0203-0016 55.2 µM 1.16398936435114 0.129220619941359 no 491 0.122214160973102 653 295302
SGTC_3147 9097027 49.47 µM 1.16359800895001 0.129300965144799 no 492 0.122293479338675 683 25236841
SGTC_121 0557-0495 61.343 µM 1.16304727345405 0.1294140896923 no 493 0.12240516142697 818 3104427
SGTC_1793 st048256 72.231 µM 1.15901571260553 0.13024428631042 no 494 0.123224890204015 647 672022
SGTC_3206 9114350 49.47 µM 1.15799688408863 0.130454669908408 no 495 0.123432653990677 618 17087243
SGTC_1910 st062352 60.4 µM 1.15756172996093 0.13054459891029 no 496 0.123521467191111 653 2245730
SGTC_2384 9036245 200 µM 1.15380011144526 0.13132376243516 no 497 0.124291064243646 671 6462766
SGTC_2872 9044037 25.97 µM 1.15368873542446 0.131346881171711 no 498 0.124313901892069 601 6465195
SGTC_1390 3413-2614 145 µM 1.15172931604293 0.131754064822399 no 499 0.1247161608056 681 3421432
SGTC_460 trequinsin 123 µM 1.15070147021794 0.131968007645594 no 500 0.124927535740556 720 5537 A vasodilator.
SGTC_226 1,3-diallylurea 8.28947 mM 1.14771768215996 0.132590430468582 no 501 0.125542564600477 610 74537 YKL182W FAS1
SGTC_2413 inermin 26.06 µM 1.14747720161516 0.132640683004943 no 502 0.125592225143493 688 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1343 1487-0095 224 µM 1.14689541754339 0.132762311028991 no 503 0.125712423412974 645 4560101 YGL055W OLE1
SGTC_3110 9122132 49.47 µM 1.14468362925742 0.133225409385907 no 504 0.126170117652129 682 918317
SGTC_3085 9117376 49.47 µM 1.14342110583846 0.133490250947879 no 505 0.126431896822744 664 16480349
SGTC_3221 9128209 49.47 µM 1.13889889137708 0.134441853315953 no 506 0.127372664040123 629 16460723
SGTC_484 loperamide 105 µM 1.13751670477026 0.134733631678104 no 507 0.12766117267518 560 3955 An opioid-receptor agonist.
SGTC_579 4491-1009 110 µM 1.13448711235741 0.135374695112873 no 508 0.12829513833079 862 1271041
SGTC_2947 9072639 7.68 µM 1.13299199767101 0.135691831406965 no 509 0.128608806926308 712 16488146
SGTC_3260 9137109 49.47 µM 1.13277983599696 0.135736875284138 no 510 0.12865336060899 555 17478346
SGTC_2680 butyl paraben 22.24 µM 1.1305241318569 0.136216415349045 no 511 0.129127717930409 645 7184 An antifungal and steroid mimetic.
SGTC_3156 9099931 49.47 µM 1.1244321783373 0.137517291870568 no 512 0.130414863714202 718 18111053
SGTC_2035 5154463 94.595 µM 1.12146805703941 0.138153308134817 no 513 0.131044340507954 698 2769623
SGTC_3314 9135860 59.4275 µM 1.12136132315577 0.138176247547098 no 514 0.131067046178136 712 25252478
SGTC_693 4161-2696 114 µM 1.12103987075967 0.138245350284435 no 515 0.131135445680089 631 805759
SGTC_820 1582-0060 59.9 µM 1.11984671309776 0.13850204981624 no 516 0.131389544555852 696 3848840
SGTC_287 k060-0039 29.6 µM 1.11627325715411 0.139272796050593 no 517 0.13215259259687 681 5861974
SGTC_1135 dihydrocapsaicin 536.708 nM 1.11240173722099 0.14011111865609 no 518 0.132982729014147 673 107982 A Capsaicinoid.
SGTC_964 1287-0107 19.4 µM 1.11205620267612 0.140186105537738 no 519 0.133056993098691 743 51516812 YPR165W RHO1
SGTC_1214 0358-0031 63.7 µM 1.11186685611116 0.140227208527788 no 520 0.133097700554241 683 4301366
SGTC_307 1501-1223 22.3 µM 1.11167259698413 0.140269386433673 no 521 0.133139473064709 685 2830329
SGTC_799 1310-0557 151 µM 1.11055734379089 0.140511699017912 no 522 0.133379466117806 690 5354492
SGTC_729 4092-0585 94.1 µM 1.10904828766224 0.14084002585599 no 523 0.13370467575044 648 2169061
SGTC_1934 st074720 32.6 µM 1.10726785969016 0.141228064154604 no 524 0.134089067950978 737 17250992
SGTC_1469 k284-2957 126 µM 1.10221849112291 0.142332496855587 no 525 0.13518334745387 682 23884841
SGTC_1160 4092-0570 10.5 µM 1.10088489451628 0.142625163123777 no 526 0.135473378566903 722 4994975
SGTC_1972 st070201 17.4 µM 1.10059396854367 0.142689062709868 no 527 0.135536705876328 708 2829099
SGTC_704 1310-0270 142 µM 1.09858484421986 0.14313087931528 no 528 0.135974595692281 724 5718033
SGTC_1603 st002045 67.8 µM 1.09699235852288 0.143481730862796 no 529 0.136322366264714 717 5887985
SGTC_3092 9117248 49.47 µM 1.0963727364283 0.143618400866142 no 530 0.136457845032455 771 17141857
SGTC_2399 5884133 200 µM 1.09434890467381 0.144065409299575 no 531 0.136900992119113 682 722445
SGTC_3192 9110362 49.47 µM 1.09068633670854 0.144876752286401 no 532 0.137705462387782 745 16649480
SGTC_2855 9016525 58.44 µM 1.09012114694361 0.145002228287844 no 533 0.13782989108654 700 43811474
SGTC_2408 sulbentine 18.36 µM 1.08845262995876 0.145373077142036 no 534 0.138197668905721 702 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1385 3091-4834 14.1 µM 1.08788776960688 0.145498768880052 no 535 0.138322328005901 667 4072814
SGTC_1741 st038134 10.228 µM 1.08399871887132 0.146366137167271 no 536 0.139182683436194 760 1272587
SGTC_1818 st052136 56.3 µM 1.08346353650059 0.146485769153943 no 537 0.139301363633627 687 674169
SGTC_1304 1165-0502 251 µM 1.08098851774922 0.147039875938309 no 538 0.139851110634997 758 767425
SGTC_1116 jasmonic acid 1.58368 µM 1.07930488882995 0.147417608707707 no 539 0.140225917118945 744 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_306 1672-3436 11.6 µM 1.07858908622502 0.147578400351794 no 540 0.140385474339405 738 6797378
SGTC_2523 spermine 47.74 µM 1.07845483333668 0.147608570826344 no 541 0.140415413936022 708 1103 A DNA binding polyamine.
SGTC_95 0471-0001 561.058 µM 1.07604911628946 0.148149904775097 no 542 0.140952645319549 694 4015405
SGTC_2430 5571206 200 µM 1.07322218509982 0.148787715877879 no 543 0.141585719525627 819 1731771
SGTC_248 streptozotocin 5.23457 mM 1.07115156643338 0.149256050730675 no 544 0.142050642553076 768 5300 DNA alkylating agent.
SGTC_2487 5918373 44.05 µM 1.07103524699292 0.149282389161687 no 545 0.142076790773283 773 2876279
SGTC_1495 4469-0029 237 µM 1.0697778734177 0.149567296715637 no 546 0.142359652091146 831 793680
SGTC_427 1354-0053 47.3 µM 1.06972468422631 0.149579356818058 no 547 0.14237162603297 716 6813657
SGTC_2553 4-methylesculetin 85.09 µM 1.06956380716445 0.149615837987776 no 548 0.142407846796884 731 5319502
SGTC_1327 1436-0082 2.18 µM 1.0691545276961 0.14970867471089 no 549 0.142500022371005 725 15992205
SGTC_321 4534-3890 65.3 µM 1.06817604357862 0.149930779671948 no 550 0.142720554475147 730 699746
SGTC_1230 0170-0365 3.77 µM 1.06751917725802 0.150080004195337 no 551 0.142868729287038 872 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_966 1300-0360 30.2 µM 1.06704200834015 0.150188467779112 no 552 0.142976433434189 723 70588
SGTC_1614 st002383 48.6 µM 1.06643739956989 0.150325974290887 no 553 0.143112981442091 735 1947235
SGTC_2300 7976697 71.57 µM 1.06630358840355 0.150356418373922 no 554 0.143143213958618 622 2236109
SGTC_479 n-linoleoylglycine 10 µM 1.06339326429401 0.151019577886689 no 555 0.143801823041019 694 6433346 An anti-infammatory.
SGTC_3335 9143315 29.6265 µM 1.06288483084977 0.151135631235262 no 556 0.143917091458239 715 4899691
SGTC_2117 5521686 200 µM 1.06286244030652 0.151140743390841 no 557 0.143922169115456 730 803312
SGTC_2962 9082311 13.18 µM 1.06250064858554 0.15122336276405 no 558 0.144004231859413 678 16459453
SGTC_1259 0671-0132 43 µM 1.0614866711349 0.151455076445402 no 559 0.144234393569994 720 X1259
SGTC_1862 st057513 3.81 µM 1.05693209274371 0.152498797158373 no 560 0.145271290240584 730 5393163
SGTC_2719 novobiocin 32.65 µM 1.05387492391442 0.15320204442012 no 561 0.145970092475118 694 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2727 riluzole 51.77 µM 1.04962780926486 0.154182578673677 no 562 0.146944633097472 685 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2497 7-hydroxyflavone 100 µM 1.04588629473625 0.155049816314235 no 563 0.147806766369332 699 5281894
SGTC_37 0566-0070 1.56 µM 1.04513789620716 0.155223671835814 no 564 0.147979620718414 813 1626686
SGTC_424 splitomicin 100 mM 1.04506322704066 0.155241024793951 no 565 0.147996874151055 702 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2904 7225135 42.03 µM 1.04490895664828 0.155276880966078 no 566 0.148032524907252 801 4446116
SGTC_1966 st070145 16.1 µM 1.03927835926556 0.156589308433208 no 567 0.149337648218834 741 3748532
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.03670674355406 0.157191144786245 no 568 0.14993627413051 790 442882
SGTC_913 3487-1245 167 µM 1.03619844394589 0.157310282159865 no 569 0.150054786285802 728 4016153
SGTC_407 eburnamonine 100 µM 1.0359264780044 0.157374051038233 no 570 0.15011822190996 698 3195
SGTC_1764 st044502 93.5 µM 1.03524388187547 0.157534176755523 no 571 0.150277515105481 764 8407
SGTC_2546 rhodinyl acetate 100 µM 1.03372166873609 0.15789164813601 no 572 0.150633150038267 801 6708682
SGTC_1409 3909-8004 61.9 µM 1.03352689113934 0.157937427456734 no 573 0.15067869637826 793 2119279
SGTC_2178 5812956 200 µM 1.03162805277665 0.158384175252718 no 574 0.151123196775695 747 5403383
SGTC_1725 st036284 20.55 µM 1.0274477944607 0.159370601058484 no 575 0.152104827962254 845 707914
SGTC_2045 5106652 78.05 µM 1.02736525380679 0.159390118789677 no 576 0.152124253145518 788 673349
SGTC_2694 st077685 81.9 µM 1.02322367983286 0.160371453029193 no 577 0.15310104961954 739 2838096
SGTC_2132 5317594 122.667 µM 1.01997327025054 0.161144387776507 no 578 0.153870568936808 720 794577
SGTC_2649 anisomycin 9.56 µM 1.01992365401494 0.161156205127728 no 579 0.153882335150109 771 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2683 piperine 63.03 µM 1.01756173887161 0.161719408564186 no 580 0.154443139002502 773 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.01643500112889 0.161988532843298 no 581 0.154711142601464 739 2346 DNA damaging agent; causes G2/M arrest.
SGTC_289 k017-0060 526 µM 1.01610254448411 0.162067996695338 no 582 0.154790278753903 746 5512909
SGTC_119 0121-0043 24.815 µM 1.01565156273994 0.162175831010452 no 583 0.154897670704692 948 1092378
SGTC_3239 9133757 49.47 µM 1.00665253677738 0.164337353584578 no 584 0.157050889106007 809 17036923
SGTC_614 0462-0418 107 µM 1.00286249531142 0.165253267560557 no 585 0.157963605205137 735 5188303
SGTC_1395 3486-0190 4.35 µM 1.00127990626112 0.165636697136477 no 586 0.158345752279469 849 6748079
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.998811563677961 0.166235874470451 no 587 0.158942991606719 874 368090
SGTC_1224 0823-0416 294 µM 0.9955660659179 0.167025829927443 no 588 0.159730514710543 819 3598164
SGTC_2908 7930301 100 µM 0.99386508652052 0.167440814237197 no 589 0.160144276908199 879 2223178
SGTC_3067 9117431 49.47 µM 0.993333029477963 0.167570755340129 no 590 0.160273843196515 761 17150885
SGTC_2264 7948757 110.76 µM 0.992599411820159 0.167750028883993 no 591 0.160452605766291 772 2971411
SGTC_776 4476-4378 112 µM 0.991040566523356 0.168131372484542 no 592 0.160832886081164 776 2892008
SGTC_549 1661-1316 519 µM 0.989678797322296 0.168464961050901 no 593 0.161165570826868 844 2857282
SGTC_412 gemfibrozil 100 µM 0.989125007354461 0.168600742982041 no 594 0.161300991888528 765 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3140 9094243 49.47 µM 0.986485467195651 0.169248889529957 no 595 0.161947471631965 874 19291112
SGTC_907 3448-6986 75.5 µM 0.984999449243833 0.169614488261907 no 596 0.162312170747657 879 590582
SGTC_3148 9097893 49.47 µM 0.983964726015676 0.169869355825358 no 597 0.162566428425511 761 17174100
SGTC_2282 7944268 200 µM 0.982384101975339 0.170259160578424 no 598 0.162955327752043 833 2970414
SGTC_968 1309-0633 340 µM 0.98182708155295 0.170396666326223 no 599 0.163092521984082 817 3761976
SGTC_688 0527-0193 473 µM 0.981708163718647 0.170426031526757 no 600 0.163121821190207 800 4007154
SGTC_3320 9137005 35.139 µM 0.981242955752662 0.170540939674244 no 601 0.163236472894407 779 4908713
SGTC_2054 5233173 129 µM 0.980122682722171 0.170817854913165 no 602 0.163512781887759 851 6889
SGTC_3059 1327-0034 3 µM 0.979153881102184 0.171057560496817 no 603 0.163751976081451 799 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1616 st002734 56.1 µM 0.978501878305277 0.171219003246991 no 604 0.163913081400816 855 4026101
SGTC_2725 haloperidol 53.21 µM 0.976706032493339 0.171664177103443 no 605 0.164357353898812 825 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1073 triclabendazole 3.09 µM 0.976352656271896 0.171751862845758 no 606 0.164444867126792 876 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1336 1486-0901 104 µM 0.974078074177781 0.172316955530388 no 607 0.165008887611686 831 5006114
SGTC_3252 9135871 49.47 µM 0.970550468021379 0.173195690456802 no 608 0.16588609083827 825 17682838
SGTC_335 4077-0256 27.6 µM 0.970428007348213 0.173226246861956 no 609 0.165916596940282 925 3121989
SGTC_1447 4239-0816 81.9 µM 0.970301492039476 0.173257818585482 no 610 0.165948116897622 766 1341554
SGTC_2327 6189656 200 µM 0.969531455527798 0.173450059162431 no 611 0.16614004683842 832 5349088
SGTC_1415 3966-0071 78.1 µM 0.969353919938006 0.173494400396345 no 612 0.166184317535778 835 2893185
SGTC_657 3534-0529 86.7 µM 0.968945932891668 0.173596326451525 no 613 0.166286083031127 856 1049549
SGTC_2394 5221648 200 µM 0.968205877894595 0.17378130916556 no 614 0.16647077997247 930 788586
SGTC_1442 4112-3290 3 µM 0.967426691636477 0.173976208500914 no 615 0.166665386050157 863 704353
SGTC_596 1155-0152 116 µM 0.965366147160129 0.174492285812714 no 616 0.167180725583338 868 280313
SGTC_2319 6033012 152.6 µM 0.964936089869784 0.174600119092623 no 617 0.167288411795873 763 847246
SGTC_1410 3909-8106 77.9 µM 0.96403724271511 0.174825634136417 no 618 0.167513627179005 822 1039210
SGTC_167 3672-0051 66.205 µM 0.961759147621012 0.175398021345959 no 619 0.168085301735114 769 3237971
SGTC_1397 3532-0190 20.1 µM 0.959072046574336 0.176074699437381 no 620 0.168761225703923 774 5322280
SGTC_3109 9122853 49.47 µM 0.958478472694676 0.1762243984975 no 621 0.168910770824023 905 1234709
SGTC_624 k048-0052 28 µM 0.955822562785446 0.176895203878453 no 622 0.169580943547667 808 6835531
SGTC_286 k060-0067 22.9 µM 0.955435172348064 0.176993182089526 no 623 0.169678837156673 827 5985051
SGTC_2987 9018338 71.43 µM 0.95492837990664 0.177121411038754 no 624 0.169806958381815 855 5055682
SGTC_2992 9074591 71.4286 µM 0.954811139431617 0.177151083655393 no 625 0.169836606554835 808 17741321
SGTC_1513 0337-0559 19 µM 0.954193369350009 0.177307488128785 no 626 0.169992885190576 777 775073
SGTC_348 k064-0012 10.7 µM 0.953742737384434 0.177421632249052 no 627 0.170106940660475 801 5066323
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.953704381761841 0.177431349788633 no 628 0.170116650776997 806 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_39 0986-0283 58.349 µM 0.952750985698169 0.177673004194335 no 629 0.17035812684451 929 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.951555063261208 0.177976424501752 no 630 0.17066134024528 882 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1028 k015-0029 4.8 µM 0.945496670581798 0.17951852940777 no 631 0.172202684893694 849 4588309
SGTC_229 benomyl 22.8748 µM 0.945149904360008 0.179607048756027 no 632 0.172291175309292 849 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2549 cedrol 20.94 µM 0.943668864098112 0.179985424017361 no 633 0.172669444812838 830 6708665 A sedative which affects the nervous system.
SGTC_900 1112-0045 141 µM 0.942264524961742 0.180344665689343 no 634 0.173028612893339 747 56211 YIL048W NEO1
SGTC_3030 9087619 49.47 µM 0.941894438027732 0.180439411870111 no 635 0.173123344009868 881 25236973
SGTC_783 0848-0141 92.7 µM 0.941583907533786 0.180518935058947 no 636 0.173202855952907 822 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_100 0086-0128 49.5915 µM 0.940300981911882 0.180847710112033 no 637 0.17353159803809 899 93297
SGTC_3198 9112019 49.47 µM 0.938617228843948 0.181279774257592 no 638 0.173963651915802 852 45595555
SGTC_2057 5236571 38.335 µM 0.936471710186516 0.181831266843303 no 639 0.174515185772986 897 54684039 YBR257W POP4
SGTC_1874 staurosporine 7.6 µM 0.936175377989638 0.181907519639671 no 640 0.174591449062463 905 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2359 9039622 200 µM 0.935356937812463 0.182118226184684 no 641 0.174802190637075 914 6463596
SGTC_1525 8-methoxypsoralen 92.5 µM 0.933921504003511 0.182488145356504 no 642 0.175172192709846 940 4114 Related to psoralen; DNA damaging agent.
SGTC_1565 sinapyl alcohol 95.1 µM 0.933693242897543 0.18254701271805 no 643 0.17523107577534 837 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2605 digitonin 300 nM 0.930897704280242 0.183268929512537 no 644 0.175953241085138 978 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2759 disulfiram 3.38 µM 0.929758003639134 0.183563754711234 no 645 0.176248197445073 830 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1482 3346-2049 8.48 µM 0.927227274012222 0.184219476517415 no 646 0.176904272417761 860 3826804
SGTC_2248 tofa 1.1 µM 0.926852760093694 0.184316638196771 no 647 0.177001493621901 850 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2788 5282734 71.43 µM 0.925498039111298 0.184668365216093 no 648 0.177353451609677 921 743706
SGTC_174 3553-0389 74.3 µM 0.924737456801043 0.184866018449792 no 649 0.17755124527186 815 738071
SGTC_252 miconazole 1.30953 nM 0.92226045538839 0.185510629967043 no 650 0.178196367802037 869 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1241 0364-0022 50.8 µM 0.919968245343798 0.186108392790191 no 651 0.178794676792234 897 4563895
SGTC_2253 7938677 135.83 µM 0.916431886294425 0.187032943681554 no 652 0.17972020875243 893 2301972
SGTC_2072 5231554 129 µM 0.916282783452697 0.187071987669578 no 653 0.17975929780197 984 789545
SGTC_560 2332-1943 155 µM 0.915657779835523 0.187235705626585 no 654 0.179923207904618 883 21177716
SGTC_432 NS 1619 61.3 µM 0.914389789348711 0.187568124299347 no 655 0.180256032571409 822 4552 A K+/calcium channel activator.
SGTC_2375 9072683 200 µM 0.913080058200436 0.187911868398241 no 656 0.180600218796994 989 16798029
SGTC_2250 alverine citrate 130 µM 0.911963085130387 0.188205329481666 no 657 0.180894075233926 928 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_414 piperonyl butoxide 100 µM 0.910478544173613 0.188595798691185 no 658 0.181285095991938 876 5794 A potent inhibitor of cytochrome P450.
SGTC_1765 st044815 90.4 µM 0.907895081638589 0.189276499979458 no 659 0.181966828206988 879 645695
SGTC_884 0851-0618 334 µM 0.90768139397513 0.189332870927148 no 660 0.18202328847425 926 9642473
SGTC_3088 9117578 49.47 µM 0.906858792025207 0.189549970316755 no 661 0.182240737482282 918 678341
SGTC_606 k015-0008 38.6 µM 0.905942544360065 0.189791964718408 no 662 0.182483132107275 982 1970475
SGTC_2778 tioconazole 65.09 nM 0.903889538353033 0.190334882984135 no 663 0.183026988515761 857 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2555 cholic acid 100 µM 0.901612264773773 0.190938223582666 no 664 0.183631436754316 899 6708657 Influences liver metabolism.
SGTC_2743 auranofin 4.32 µM 0.901292383316845 0.191023066810167 no 665 0.183716441220615 884 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_441 propafenone 146 µM 0.899462105797016 0.191508961924924 no 666 0.184203285702788 904 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1460 k062-0059 9.15 µM 0.898839678737213 0.191674373880705 no 667 0.184369030915926 877 1373085
SGTC_1180 1193-0155 285 µM 0.896302297605898 0.192349595874735 no 668 0.185045666165238 871 2921347
SGTC_353 1988-1175 58.3 µM 0.895228846080173 0.192635689171247 no 669 0.185332383816613 864 2788357
SGTC_1624 st003710 6.25 µM 0.891669174059035 0.193586262552497 no 670 0.186285140432946 967 24207033
SGTC_405 ebelactone b 50 µM 0.890706202994379 0.19384390475674 no 671 0.186543403078987 916 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2276 7947513 42.08 µM 0.890453529450437 0.193911541978103 no 672 0.186611205203711 858 2105100
SGTC_1260 0700-1617 7.75 µM 0.890041337566829 0.194021910923128 no 673 0.186721845038788 917 2853078
SGTC_2084 5306078 60.6385 µM 0.889713543371235 0.19410970876793 no 674 0.18680985997197 888 679340
SGTC_2760 etidronate 98.04 µM 0.888964975088857 0.194310299326054 no 675 0.187010951813801 890 3305 A chelator and antioxidant.
SGTC_981 1488-1094 54.9 µM 0.888871431532222 0.194335374651313 no 676 0.187036090321828 874 3449522
SGTC_2015 5119600 184 µM 0.888152813855978 0.194528073307581 no 677 0.187229278366391 928 2828786
SGTC_2090 5301565 104.445 µM 0.887902809015341 0.19459513982387 no 678 0.187296516802473 946 2056344
SGTC_1466 k213-0079 57.5 µM 0.887032614969357 0.194828688536319 no 679 0.187530670615096 943 3657981
SGTC_263 alizarin 107.927 µM 0.884427132085983 0.195528984839873 no 680 0.188232840942568 984 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_802 4112-3352 742 µM 0.882703905593639 0.195992988805009 no 681 0.18869813570703 980 704594
SGTC_344 k064-0035 6.43 µM 0.874469514249855 0.198219426771887 no 682 0.19093130764599 907 5088750
SGTC_346 4513-0042 7.16 µM 0.872008253521492 0.198887861666897 no 683 0.191601937479981 939 2827372
SGTC_2928 9011484 9.79 µM 0.872007984540512 0.198887934791544 no 684 0.191602010849095 880 2994751
SGTC_1703 st026983 48.3 µM 0.871717703601142 0.19896685944921 no 685 0.19168119991773 974 1104023
SGTC_2735 sertaconazole 140 nM 0.8703071845126 0.199350634931082 no 686 0.19206627686273 933 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_782 0083-0095 30.5 µM 0.869518055820365 0.199565536172479 no 687 0.192281918273476 993 3591729 An indicator and reagent.
SGTC_3269 9137823 49.47 µM 0.868939008793953 0.199723315104439 no 688 0.192440245831176 866 17682936
SGTC_2357 9067248 200 µM 0.868308371938794 0.199895236596908 no 689 0.192612770130982 917 9150235
SGTC_2146 5545642 200 µM 0.867462548998481 0.20012596086952 no 690 0.192844311584064 985 825326
SGTC_670 4204-0025 119 µM 0.867223884380154 0.200191092943322 no 691 0.192909676040703 983 719039
SGTC_794 k038-0031 316 µM 0.867219023096767 0.200192419730102 no 692 0.192911007569051 986 6624242
SGTC_3294 9122953 26.2835 µM 0.864024203548672 0.201065522225856 no 693 0.193787297368221 1014 16459826
SGTC_2376 9072922 81.32 µM 0.863641840909064 0.201170169760813 no 694 0.193892335894179 964 17087968
SGTC_1738 st035555 74 µM 0.861340243536515 0.201800775843519 no 695 0.194525338590654 958 5331140
SGTC_1802 st050112 57.9 µM 0.861023315219597 0.20188770247456 no 696 0.194612601024209 998 4662563
SGTC_342 k048-0088 23.3 µM 0.857943020352689 0.202733728353654 no 697 0.195461963732255 954 6820570
SGTC_1476 4112-3294 3.34 µM 0.85594693459222 0.203283097584848 no 698 0.196013566132648 984 704369
SGTC_2496 diffractaic acid 79.83 µM 0.854764021675308 0.203609081572175 no 699 0.196340899853435 979 94870 An apoptosis inducer which activates caspases.
SGTC_3158 9100007 49.47 µM 0.854199162145425 0.203764853963223 no 700 0.196497323678129 932 19297233
SGTC_3245 9134821 49.47 µM 0.853734315312232 0.203893098935228 no 701 0.196626108096281 988 17014901
SGTC_1540 guanosine 70.6 µM 0.85315670970882 0.204052519533177 no 702 0.19678620321496 919 6802 Guanosine is a purine nucleoside
SGTC_2979 9012552 45.46 µM 0.852130427543338 0.204335959107074 no 703 0.197070852809296 929 17100905
SGTC_2806 7952793 58.44 µM 0.850766039929688 0.204713139693561 no 704 0.197449664934518 953 2972490
SGTC_3113 9123498 49.47 µM 0.849296001993832 0.205119990112711 no 705 0.197858302477297 1045 8897275
SGTC_2283 7944793 200 µM 0.84827293148877 0.2054034203683 no 706 0.198142994394298 1007 2970533
SGTC_3060 1327-0027 12.5 µM 0.847077230511869 0.20573497057121 no 707 0.198476037794522 936 16000455 YPR107C YTH1
SGTC_2172 5754775 163.918 µM 0.846546833194686 0.205882143534264 no 708 0.198623879557923 898 2263357
SGTC_2233 sulbentine 40.3845 µM 0.845287288626618 0.206231888130585 no 709 0.198975228227742 1006 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_992 3909-8734 162 µM 0.844096203911259 0.206562946875592 no 710 0.199307824405 968 4288319
SGTC_892 0929-0076 29 µM 0.843430770041125 0.20674803937845 no 711 0.199493784538498 1001 5751038
SGTC_2007 4011539 71.82 µM 0.841351360037164 0.207327066260706 no 712 0.200075562893443 960 45595301
SGTC_1212 0520-0165 585 µM 0.841249429601832 0.207355474164592 no 713 0.200104107239032 959 5403258
SGTC_1326 1431-2094 10.8 µM 0.840522912275592 0.20755802041937 no 714 0.200307630238045 950 616278
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.84032607080914 0.207612918108167 no 715 0.200362793846529 984 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2231 micatex 6.853 µM 0.838432757263489 0.208141387811702 no 716 0.200893849218285 1008 20737 An antifungal of unknown mechanism.
SGTC_2486 5283202 22.39 µM 0.837943200596084 0.208278164009751 no 717 0.201031302232098 911 1377751
SGTC_2799 7812892 81.82 µM 0.834989938381955 0.209104393778942 no 718 0.201861686751887 1004 20205235
SGTC_3017 9080681 49.47 µM 0.832790942125971 0.209720855319239 no 719 0.202481322040138 968 16451914
SGTC_1416 3966-0321 25.3 µM 0.832447448553881 0.209817245920866 no 720 0.202578214577446 1020 582530 YLR208W SEC13
SGTC_147 4466-0538 29.23 µM 0.832298047435688 0.209859178742948 no 721 0.202620366235806 1110 6742687 YHR072W ERG7
SGTC_2773 thioridazine 9.09 µM 0.831510510517869 0.210080300299721 no 722 0.202842646568139 1058 5452 An antipsychotic.
SGTC_3014 9081533 49.47 µM 0.830756913772101 0.210292020369678 no 723 0.203055483701421 1006 21367265
SGTC_1915 st067105 30.6 µM 0.830500500587315 0.210364087213531 no 724 0.203127932463916 998 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_836 0330-0104 1.35 µM 0.828601124350542 0.210898372457881 no 725 0.203665075789541 1019 46494820
SGTC_3232 9132874 49.47 µM 0.828458055213743 0.210938649305329 no 726 0.203705569991951 970 3784940
SGTC_26 0302-0163 425.158 µM 0.826339753500355 0.211535521490556 no 727 0.204305694353147 1023 3100915
SGTC_1853 st056710 91.2 µM 0.826167827351362 0.211584008331225 no 728 0.204354447942457 1063 269167
SGTC_1293 1000-1278 195 µM 0.825595372183057 0.211745499788681 no 729 0.204516830607188 1018 678847
SGTC_850 0388-0143 75.9 µM 0.824829550432818 0.211961653339691 no 730 0.20473418368033 970 67273
SGTC_2710 st078562 53.7235 µM 0.824613262080442 0.212022724193777 no 731 0.20479559482017 1031 17250908
SGTC_2731 amoxapine 43.43 µM 0.823932178589434 0.212215101113694 no 732 0.204989047629073 1004 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1413 3910-0535 34.4 µM 0.823893191673269 0.212226116334624 no 733 0.20500012463606 1035 2876951
SGTC_2940 9060638 45.86 µM 0.823110466767859 0.21244733527264 no 734 0.205222588599715 973 4027022
SGTC_69 0096-0274 206.684 µM 0.822779673336548 0.212540866804146 no 735 0.205316648919578 1112 6741392
SGTC_2789 5281112 71.43 µM 0.820687591384548 0.213132957846064 no 736 0.205912120298101 980 765948
SGTC_392 N-ethylmaleimide 8.33 µM 0.82059090286011 0.213160345410197 no 737 0.205939665594829 960 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_795 0685-0265 78 µM 0.819780994586308 0.21338983704419 no 738 0.206170483696493 1087 302754
SGTC_1848 st056003 16.4 µM 0.818117237733895 0.213861722590317 no 739 0.206645123443884 1103 146492
SGTC_566 0958-0068 16.5 µM 0.818109956981837 0.21386378893902 no 740 0.206647201931869 966 6815365
SGTC_1965 Pectolinarigenin 58.4 µM 0.816769302042893 0.21424447804927 no 741 0.207030139206495 1047 5320438 An anti-inflammatory.
SGTC_2786 7743617 45.45 µM 0.815390759670948 0.214636336365155 no 742 0.207424335936603 921 583674
SGTC_454 lyso-paf C-16 6.67 µM 0.814762308285258 0.214815115305841 no 743 0.207604189909229 1031 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2403 6032726 181.2 µM 0.813393119310261 0.215204915267552 no 744 0.207996351522223 989 2881040
SGTC_3222 9128301 49.47 µM 0.813300384288604 0.215231331213357 no 745 0.208022928389714 1035 4911358
SGTC_2652 actinonin 100 µM 0.812336375174783 0.21550604454814 no 746 0.208299321825647 1003 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2112 5488546 200 µM 0.810907157723081 0.215913702170535 no 747 0.208709494746415 1009 600757
SGTC_2733 amorolfine 100 µM 0.808000174361367 0.216744242219582 no 748 0.209545240883903 1003 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1381 2324-0066 62.1 µM 0.807321997756836 0.216938266194306 no 749 0.209740496778419 974 10885928
SGTC_1232 0279-0259 161 µM 0.806972174889487 0.217038388539637 no 750 0.209841257154974 1015 1560000
SGTC_1353 1498-1206 8.11 µM 0.800519347594152 0.21889002730672 no 751 0.211704979229322 1062 6756808
SGTC_3275 9138069 49.47 µM 0.80027164978713 0.218961284845484 no 752 0.211776712486058 1027 17617007
SGTC_2310 7668677 200 µM 0.79983644297619 0.219086517160248 no 753 0.211902782771317 1024 2197143
SGTC_2944 9067346 25.62 µM 0.799472418411856 0.219191298154283 no 754 0.212008266763689 959 6473075
SGTC_2476 5806916 10.51 µM 0.798844875773659 0.219371997931284 no 755 0.212190182902891 1000 2870194
SGTC_2334 9017922 200 µM 0.798233002945428 0.219548268006726 no 756 0.212367644406837 1054 3163164
SGTC_1226 3909-7979 35.4 µM 0.797224341662695 0.21983902355548 no 757 0.212660375729862 1062 6615510
SGTC_1859 st055998 20 µM 0.797158344093108 0.21985805563996 no 758 0.212679537599826 1060 676301
SGTC_949 1165-0505 146 µM 0.79624814841382 0.220120630243624 no 759 0.212943908497199 1061 6244267
SGTC_2774 tamoxifen 10.92 µM 0.795506426460473 0.220334736242538 no 760 0.213159487097379 1079 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3106 9121286 49.47 µM 0.795375078123495 0.220372663788187 no 761 0.213197676242892 1019 15943471
SGTC_1299 1079-1439 3.74 µM 0.794273542979815 0.220690885304675 no 762 0.213518101383003 1046 323161
SGTC_1682 st012968 530 nM 0.792875211757129 0.221095226856563 no 763 0.213925265406851 966 24207270
SGTC_278 4092-0821 23.9 µM 0.792837970404247 0.221106001360768 no 764 0.213936115465226 1046 877900
SGTC_409 arachidonic acid 100 µM 0.791010879453788 0.221634976093419 no 765 0.214468821426206 1078 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1662 st014054 52 µM 0.790263061380739 0.221851690883093 no 766 0.214687077228326 1070 2838777
SGTC_399 oxolinic acid 75 µM 0.790204755052281 0.22186859291653 no 767 0.2147040997503 1020 4628 A DNA gyrase inhibitor.
SGTC_1205 4161-2785 76 µM 0.788787245643783 0.222279731502147 no 768 0.215118182627781 942 3498106
SGTC_3051 9093778 49.47 µM 0.787736932628317 0.222584647531846 no 769 0.215425298895315 1029 17217378
SGTC_555 4296-0685 37 µM 0.78731385265439 0.222707539085061 no 770 0.215549081218744 1067 2908540 YHR072W ERG7
SGTC_881 0833-0569 170 µM 0.786560935080846 0.222926333803936 no 771 0.215769467533941 1004 5418700
SGTC_1296 1068-0102 11.9 µM 0.786362908491903 0.222983899838869 no 772 0.215827453533717 1026 767053
SGTC_531 3788-1495 174 µM 0.785921810815373 0.223112156706675 no 773 0.215956647888728 992 2896655
SGTC_620 0109-0052 432 µM 0.78447666073087 0.223532653497692 no 774 0.216380235756841 1079 493037
SGTC_1238 0333-0287 48.8 µM 0.784406771246841 0.223553000732656 no 775 0.216400733243132 1073 7226
SGTC_2005 4024620 188 µM 0.783986433957347 0.22367539760674 no 776 0.216524035259996 1061 236743
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.781583834442348 0.224375734938454 no 777 0.217229595145816 1186 688664
SGTC_2714 st079313 56.9 µM 0.780358602254524 0.224733358359182 no 778 0.217589913899486 1045 2939799
SGTC_1629 st005085 44.9 µM 0.78019931776913 0.224779874390909 no 779 0.217636781923794 1060 24207091
SGTC_1905 st060207 84.5 µM 0.779839403076241 0.224885000795741 no 780 0.217742705028391 1041 1948547
SGTC_2826 7992541 19.48 µM 0.777487522967284 0.225572640153092 no 781 0.218435596455014 1129 2985066
SGTC_82 0054-0107 293.755 µM 0.776094464785007 0.225980501013982 no 782 0.21884660584099 1072 3104697
SGTC_1845 st056753 3.01 µM 0.775800976466456 0.226066481934506 no 783 0.218933253662168 1080 5375839
SGTC_173 1273-0061 2.693 µM 0.774839192289034 0.22634837768432 no 784 0.219217343611923 1057 2847414 YPL266W DIM1
SGTC_2360 9040895 200 µM 0.772874200406926 0.226924927019571 no 785 0.219798417371776 1022 4914414
SGTC_2845 9003024 42.97 µM 0.769780533901886 0.227834317729243 no 786 0.220715044335991 1104 2990173
SGTC_24 0417-1663 219 µM 0.769407295147862 0.22794417062066 no 787 0.22082577960334 1081 4329390
SGTC_593 1203-0218 61.7 µM 0.769295316549656 0.227977134350077 no 788 0.220859008454728 1130 3666956
SGTC_1583 clindamycin 39.6 µM 0.76841044743437 0.228237712225981 no 789 0.221121687734145 1000 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.767563117728069 0.22848739227718 no 790 0.221373390650312 1029 15053
SGTC_340 k038-0059 454 µM 0.76640522109502 0.228828834116483 no 791 0.221717613572303 1091 23733424
SGTC_133 0724-0033 378.92 µM 0.76612116576585 0.228912640392721 no 792 0.221802105066154 1019 280309
SGTC_975 1335-0046 28.5 µM 0.76588725168754 0.228981666173232 no 793 0.221871695986441 1100 16486740
SGTC_304 1310-0298 97 µM 0.764178972287488 0.229486116815591 no 794 0.222380297856211 1069 1550234
SGTC_1870 st057514 26.5 µM 0.764001317564587 0.229538613537579 no 795 0.222433228714379 1096 5393161
SGTC_1809 st050081 57.6 µM 0.760767720666474 0.230495311893536 no 796 0.223397908863044 1123 5036894
SGTC_2955 9076254 12.21 µM 0.760079157322077 0.230699319045208 no 797 0.223603635209952 1056 16459619
SGTC_463 ikarugamyin 104 µM 0.759094141829099 0.230991334153181 no 798 0.223898121627175 1117 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1627 st003713 25.6 µM 0.758394365597814 0.231198913278075 no 799 0.224107464961315 1143 16195070 YER133W GLC7
SGTC_956 1185-0240 191 µM 0.757036238501551 0.231602080108549 no 800 0.224514076016065 1082 1416193
SGTC_1216 1165-0504 9.65 µM 0.756952567732478 0.231626931002934 no 801 0.224539139974254 1099 6304004
SGTC_3145 9085516 49.47 µM 0.755663050070719 0.232010116055794 no 802 0.224925621554116 1109 25236195
SGTC_2849 9019321 12.99 µM 0.755051478019654 0.232191970320658 no 803 0.225109047667927 1058 16489627
SGTC_451 chloral hydrate 100 µM 0.754739209019758 0.2322848557848 no 804 0.22520273780947 1154 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_737 1950-0117 57.9 µM 0.753094470520306 0.23277442984107 no 805 0.225696573475095 1100 5393513
SGTC_567 1080-0542 68.4 µM 0.752823192616524 0.232855233668335 no 806 0.22577808396603 1064 5950415
SGTC_726 3448-4391 34.2 µM 0.752798530972939 0.232862580248231 no 807 0.225785494841025 1161 1356692
SGTC_709 3807-1509 243 µM 0.751837468589539 0.233148976177324 no 808 0.226074403212941 1126 1886677 YPL242C IQG1
SGTC_1954 st077032 68.9 µM 0.750822281511392 0.233451713482408 no 809 0.226379809001143 1062 698907
SGTC_717 1532-0246 73.2 µM 0.750393678260373 0.233579592003107 no 810 0.226508818619429 1093 9561992
SGTC_259 usnic acid 108.925 µM 0.74955292080702 0.233830554085672 no 811 0.226762007226783 1162 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.748594627222919 0.234116782270556 no 812 0.227050785703254 1156 1273210
SGTC_2202 7226349 200 µM 0.74689955087171 0.234623551411317 no 813 0.227562098547834 1095 844334
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.746699680856325 0.23468334558316 no 814 0.227622431224896 1196 6710655
SGTC_303 1348-1668 34.2 µM 0.746472123255749 0.234751433176282 no 815 0.227691132626921 1107 5380509
SGTC_2012 4023501 200 µM 0.746415483624602 0.234768382038356 no 816 0.227708234384284 1082 3477460
SGTC_1885 st057546 99.9 µM 0.745520611927029 0.235036253501276 no 817 0.227978527677655 1145 702008
SGTC_2059 5238311 157 µM 0.744558363642487 0.235324481813846 no 818 0.22826937313156 1124 703021
SGTC_1878 temozolomide 1 mM 0.74356083009638 0.235623485212282 no 819 0.228571103827674 1096 5394 DNA alkylating agent.
SGTC_387 norethindrone acetate 66.7 µM 0.743494187857766 0.235643468201771 no 820 0.22859126953447 1074 541197
SGTC_2636 apigenin dimethyl ether 100 µM 0.741704521957316 0.236180457436806 no 821 0.22913318972443 1120 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3253 9135987 49.47 µM 0.741074046060081 0.236369792147261 no 822 0.229324272621655 1082 4182430
SGTC_3058 9093861 49.47 µM 0.741020723985825 0.236385808834266 no 823 0.229340437425069 1124 17217477
SGTC_708 3448-5400 146 µM 0.740214455087855 0.236628065701073 no 824 0.229584938952188 1138 3462195
SGTC_2942 9052777 62.25 µM 0.737583775532612 0.237419446071485 no 825 0.230383708806723 1191 6469503
SGTC_48 0382-0018 55 µM 0.737542457388362 0.237431887279084 no 826 0.230396266877177 1220 762596
SGTC_83 0170-0301 39.027 µM 0.73697138126801 0.237603879298509 no 827 0.230569876648908 1087 3089716
SGTC_2270 7924575 90.91 µM 0.735387413749513 0.238081283233323 no 828 0.231051792459715 1119 1262135
SGTC_563 tetrahydrosecaminediol 614 µM 0.73462067673839 0.238312564583656 no 829 0.231285270924499 1170 334274 A psychoactive constituent of the cannabis plant.
SGTC_2822 7994718 71.43 µM 0.734481548738305 0.238354544848248 no 830 0.231327650781182 1067 1018011
SGTC_1125 tnp00248 1.32998 µM 0.734349179515528 0.238394489489342 no 831 0.231367975863406 1233 24207736
SGTC_2435 5706476 10.6 µM 0.733710600030166 0.238587243086956 no 832 0.23156256837243 1166 5725375
SGTC_1359 1582-0056 520 nM 0.733530424167748 0.238641644139138 no 833 0.23161748934698 1159 3661189
SGTC_2963 9082507 9 µM 0.731407741418805 0.239283063059944 no 834 0.232265069073939 1121 16459611
SGTC_2607 solasodine 47.35 µM 0.730044453209693 0.239695509096714 no 835 0.232681506401994 1145 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1633 st005664 67.9 µM 0.729314786928731 0.239916419924617 no 836 0.232904564566025 1175 2063822
SGTC_2539 epi(13)torulosol 80 µM 0.727834579711762 0.240364902420143 no 837 0.233357426934876 1137 6708597
SGTC_2304 7443016 91.4 µM 0.727681330023021 0.240411361050027 no 838 0.233404340843454 1075 939854
SGTC_3135 9127742 49.47 µM 0.726520485492225 0.240763437338856 no 839 0.233759876889089 1089 3643468
SGTC_2835 9006588 71.43 µM 0.725914416280364 0.240947365452793 no 840 0.233945619101408 1131 2345538
SGTC_2030 5175110 200 µM 0.725497082610892 0.241074061072877 no 841 0.234073566996878 1178 2831986
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.724846992747483 0.241271489772792 no 842 0.234272951437014 1113 756377
SGTC_1456 k015-0012 13 µM 0.724440098690754 0.241395105944026 no 843 0.234397794840277 1220 2989616
SGTC_3272 9137413 49.47 µM 0.723282757570787 0.2417468992084 no 844 0.234753091915745 1134 17614870
SGTC_3353 9151644 39.2805 µM 0.720959682182425 0.242453875995228 no 845 0.235467160501605 1149 4909158
SGTC_3317 9138495 8.753 µM 0.720552903852511 0.242577785139709 no 846 0.235592319515454 1168 17020139
SGTC_1713 st033146 12.748 µM 0.720113231191431 0.242711752813611 no 847 0.23572764083522 1155 674619
SGTC_1955 wogonin 32.4 µM 0.719588174283196 0.242871789412826 no 848 0.23588929763975 1160 5281703 A flavanone.
SGTC_825 1988-2224 89.6 µM 0.719118836228617 0.243014891302064 no 849 0.236033851191187 1144 1180859
SGTC_2258 7960471 200 µM 0.719064275221101 0.243031529995094 no 850 0.236050658849147 1121 2974708
SGTC_1251 0490-5699 265 µM 0.717843219271271 0.24340405917698 no 851 0.236426980728501 1213 3883818
SGTC_591 4299-0174 154 µM 0.717063501259604 0.243642102891439 no 852 0.236667457649712 1123 5509088
SGTC_1926 methyl fluorone black 53.6 µM 0.716980474052473 0.243667458054638 no 853 0.236693072430313 1033 72721 Reacts with homocysteine.
SGTC_331 k048-0133 24.5 µM 0.715512277457528 0.24411605675546 no 854 0.237146278584349 1156 6813582
SGTC_3160 9100216 49.47 µM 0.714479744673814 0.244431807536044 no 855 0.237465288400287 1136 17191039
SGTC_1037 k284-1091 78.7 µM 0.713256288785808 0.244806227692752 no 856 0.237843590276739 1162 3334711
SGTC_2471 5466956 24.79 µM 0.711703731580542 0.245281808431642 no 857 0.238324128221784 1123 724419
SGTC_1177 0983-0204 23.6 µM 0.709779427769499 0.245871951541439 no 858 0.238920464133533 1206 766818
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.708139328415408 0.24637553610343 no 859 0.239429369364191 1171 5377381
SGTC_206 4546-0025 72.014 µM 0.705881452921992 0.247069709213195 no 860 0.240130931251667 1210 6620745 YIL048W NEO1
SGTC_1617 st002906 78 µM 0.703648725280376 0.247757178276939 no 861 0.240825779671992 1183 5150859
SGTC_612 0302-0167 22.4 µM 0.701759586249865 0.248339651260207 no 862 0.241414553013907 1219 235821
SGTC_2161 5662504 8.5105 µM 0.700595692226726 0.248698874556315 no 863 0.241777683768883 1157 2859334
SGTC_1027 k015-0025 8.67 µM 0.700550073035121 0.248712960059697 no 864 0.241791922827299 1183 3598955
SGTC_500 h-89 112 µM 0.6998115176364 0.248941057497828 no 865 0.242022510464853 1217 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2447 5741742 33.78 µM 0.699208572136859 0.249127355321447 no 866 0.242210847127118 1209 1776504
SGTC_2766 oltipraz 83.91 µM 0.699027484436553 0.24918332219365 no 867 0.242267427372533 1166 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3019 9081971 49.47 µM 0.697480941420943 0.249661568274994 no 868 0.242750931257205 1239 16451803
SGTC_1455 4262-0120 131 µM 0.697012535069212 0.24980651229956 no 869 0.24289747458641 1252 1529587
SGTC_3077 9117319 49.47 µM 0.696138059051729 0.250077230351276 no 870 0.243171186939297 1214 17154678
SGTC_3296 9122258 64.045 µM 0.696120528499471 0.250082659005773 no 871 0.243176675733916 1185 4730474
SGTC_320 4092-0846 5.34 µM 0.695770712146432 0.250190999074261 no 872 0.243286216812097 1172 1359356
SGTC_1198 1612-1005 86.7 µM 0.695096873359441 0.250399760825514 no 873 0.243497297036328 1245 6998509
SGTC_649 1123-0311 367 µM 0.693885046056449 0.250775428809175 no 874 0.243877151145494 1180 693629 YIL048W NEO1
SGTC_2699 st077704 54.6 µM 0.693746722466977 0.250818328262941 no 875 0.243920529779561 1197 645852
SGTC_2121 5257820 149.641 µM 0.692181213704475 0.251304123306859 no 876 0.244411767428711 1240 791256
SGTC_3166 9102297 49.47 µM 0.691952737410462 0.251375063655599 no 877 0.244483505068724 1174 25237072
SGTC_459 nigericin 15.3 µM 0.691950156409151 0.251375865099564 no 878 0.244484315523686 1259 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_838 0109-0203 71.4 µM 0.691839417329506 0.251410252703349 no 879 0.244519089839706 1208 759422
SGTC_2442 5158906 48.48 µM 0.689749687719846 0.25205963849736 no 880 0.245175806575783 1206 1893835
SGTC_3208 9114115 49.47 µM 0.689145901735675 0.252247430305784 no 881 0.245365728323328 1178 650895
SGTC_140 0062-0056 502.533 µM 0.688058858599251 0.252585712474502 no 882 0.245707858532158 1199 3758964
SGTC_1134 3477-0009 42.5 µM 0.687802556285343 0.252665507223909 no 883 0.245788563069434 1244 3973534
SGTC_3304 9125678 46.087 µM 0.687322936801151 0.252814863099123 no 884 0.245939623996324 1204 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1407 3909-7909 12.3 µM 0.687058091136136 0.252897357261613 no 885 0.246023061118818 1224 4411780
SGTC_3005 9076496 71.4286 µM 0.686813578799569 0.252973530572442 no 886 0.246100105898625 1215 21368410
SGTC_2369 9071472 200 µM 0.686587899975689 0.253043847362375 no 887 0.246171227803028 1237 17296037
SGTC_2924 9010168 62.78 µM 0.68653443808375 0.253060506473428 no 888 0.246188077748946 1231 2993929
SGTC_311 1315-0136 58 µM 0.686244447739325 0.253150879608047 no 889 0.246279486741335 1245 6759207
SGTC_471 1-acyl-paf 4 µM 0.685794941194207 0.2532909982123 no 890 0.246421213414581 1166 16759367
SGTC_1300 1094-0077 113 µM 0.685120910745193 0.253501181006548 no 891 0.246633812987933 1175 5532636
SGTC_1734 st037168 69.4 µM 0.682473272911815 0.254327679597665 no 892 0.247469868671261 1203 708907
SGTC_1631 benzylvanillin 81.9 µM 0.681994780790747 0.254477198425722 no 893 0.247621125549654 1222 75506
SGTC_3273 9137859 49.47 µM 0.68133969981852 0.254681972261851 no 894 0.24782828425535 1280 2377234
SGTC_2269 7935389 174.42 µM 0.680434267642709 0.254965146166446 no 895 0.248114764700116 1178 97605
SGTC_112 phenothiazine 287.218 µM 0.679418154013158 0.255283131770546 no 896 0.248436475202289 1216 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1569 carminic acid 40.6 µM 0.678915291665244 0.255440575655177 no 897 0.248595768033305 1227 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1879 gemcitabine 100 µM 0.678706518607588 0.255505956440283 no 898 0.24866191752172 1231 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3318 9139014 38.6185 µM 0.678476955464965 0.255577858079956 no 899 0.248734665143538 1217 16643984
SGTC_3003 9075612 71.4286 µM 0.678344379782574 0.255619387020058 no 900 0.248776682997389 1220 6501993
SGTC_2949 9072542 2.23 µM 0.677146773397103 0.255994693328664 no 901 0.249156417399363 1242 16457352
SGTC_2591 skatole 100 µM 0.67653745843401 0.25618575094504 no 902 0.249349735911054 1237 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_945 3381-0768 11.3 µM 0.676517813871434 0.256191911957368 no 903 0.249355969905136 1235 1126236 YIL048W NEO1
SGTC_430 0958-0115 16.4 µM 0.676182960769201 0.256296941910217 no 904 0.249462244735272 1196 6833180
SGTC_1032 k061-1018 98.7 µM 0.674485665729162 0.256829660122253 no 905 0.250001297949687 1309 4005393
SGTC_23 0213-0011 39.996 µM 0.673098703793884 0.257265403713689 no 906 0.250442249252515 1256 627608
SGTC_1344 1488-0097 29.1 µM 0.672638652394803 0.257410023472628 no 907 0.250588602551314 1223 747966
SGTC_1959 st077091 55.8 µM 0.671333310710077 0.257820594855822 no 908 0.251004109343433 1245 821356 YKL052C ASK1
SGTC_3103 9120822 49.47 µM 0.67091165441245 0.257953291726383 no 909 0.25113840574256 1299 17141819
SGTC_2280 7785178 200 µM 0.668535993332149 0.258701583084639 no 910 0.251895757156039 1237 2954328
SGTC_958 1222-0007 33 µM 0.668448655225001 0.258729114447068 no 911 0.251923623157173 1298 7312461
SGTC_692 k241-0027 77.8 µM 0.666972842408392 0.259194560267596 no 912 0.252394740299805 1295 3600480
SGTC_3227 9130768 49.47 µM 0.666226196522482 0.259430204224874 no 913 0.252633265512569 1256 17720899
SGTC_2115 tiliquinol 12.7705 µM 0.66592636521043 0.259524863129216 no 914 0.252729083716022 1232 71208 A bioactive hydroxyquinoline.
SGTC_3276 9139060 49.47 µM 0.66526132854998 0.259734883626878 no 915 0.252941680223831 1292 4870619
SGTC_330 1488-0319 80.1 µM 0.662267850285751 0.260681317520833 no 916 0.253899788535898 1247 6846614
SGTC_2917 7979103 53.79 µM 0.66185963760307 0.260810517580738 no 917 0.254030590647421 1254 2980565
SGTC_1096 rimcazole 32.2 µM 0.659937786477437 0.261419229306037 no 918 0.254646877148655 1195 18528119 A dopamine reuptake inhibitor.
SGTC_2809 7964133 12.99 µM 0.659153639843703 0.261667803029199 no 919 0.254898556840302 1250 1253665
SGTC_2469 5655019 90.81 µM 0.658937661075464 0.261736289387527 no 920 0.254967900241402 1303 2788239
SGTC_2211 7117706 200 µM 0.656278349530083 0.262580303897056 no 921 0.255822522617499 1214 822771
SGTC_371 0195-0006 7.36 µM 0.655223102198323 0.262915604773069 no 922 0.256162061133323 1171 3928593
SGTC_1462 k081-0014 26.5 µM 0.654306245773265 0.263207110079079 no 923 0.25645726138561 1075 3270634
SGTC_1213 1315-0166 115 µM 0.653921685851519 0.263329426177839 no 924 0.256581130879561 1221 768401
SGTC_499 genistein 192 µM 0.653770602888651 0.263377488732333 no 925 0.256629804304154 1270 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1656 st012921 11 µM 0.653369867044434 0.263504992622702 no 926 0.256758930075955 1212 6732821
SGTC_2868 9035608 32.47 µM 0.651628583118219 0.26405939021561 no 927 0.257320402006954 1253 6462614
SGTC_2461 5755302 26.15 µM 0.651396282572314 0.264133395986212 no 928 0.257395354855532 1291 2788904
SGTC_264 promethazine 12.5 mM 0.650310888086147 0.264479318408554 no 929 0.257745712693136 1294 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1203 3992-3522 103 µM 0.649472273431954 0.264746748248782 no 930 0.258016581128781 1458 5322312
SGTC_195 4234-0266 16.654 µM 0.648891303964661 0.264932096971772 no 931 0.258204317963106 1267 2303354
SGTC_521 r062-0005 13.8 µM 0.64647892197269 0.265702432411765 no 932 0.258984621692092 1204 2832033
SGTC_360 0957-0399 1.01 µM 0.645340262187399 0.26606642980363 no 933 0.259353353310342 1280 6752301 YPR165W RHO1
SGTC_254 nsc-64875 3.808 µM 0.645231416126727 0.26610123803678 no 934 0.259388615072647 1309 56993
SGTC_1220 1838-0075 193 µM 0.645056782298636 0.266157089570074 no 935 0.259445194609636 1209 5529645
SGTC_1072 oxiconazole 14.9 nM 0.644917299891161 0.266201703210529 no 936 0.259490390032008 1296 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3074 9116018 49.47 µM 0.644761361578537 0.266251584776737 no 937 0.259540922349509 1314 17027303
SGTC_2635 hydroquinidine 100 µM 0.644228182548274 0.266422173885394 no 938 0.259713739130471 1289 442912 An experimental heart treatment.
SGTC_1003 4049-0218 100 µM 0.643940332300843 0.266514293729462 no 939 0.259807063341444 1311 295161
SGTC_2797 7859098 81.82 µM 0.643764446367434 0.266570589900919 no 940 0.25986409600769 1295 972681
SGTC_2452 5863136 48.41 µM 0.642718847213783 0.266905381050385 no 941 0.260203274632305 1247 2184096
SGTC_190 3970-0790 3.722 µM 0.642342063590419 0.267026075712677 no 942 0.260325554186301 1273 2832352
SGTC_667 1498-1044 59 µM 0.641958233996818 0.267149055735383 no 943 0.260450150839274 1308 6739982
SGTC_1169 aniline yellow 25.8 µM 0.641539226429067 0.267283339508856 no 944 0.260586201827288 1257 6051 A DNA damaging agent.
SGTC_2856 9022925 19.48 µM 0.641305306292182 0.267358321173673 no 945 0.260662171176972 1282 4944862
SGTC_509 pifithrin 175 µM 0.641291536217099 0.267362735417463 no 946 0.260666643586911 1334 4817 A p53 inhibitor.
SGTC_3043 9092303 49.47 µM 0.638790467166609 0.268165107133369 no 947 0.261479625295515 1234 25236084
SGTC_716 1683-5115 658 µM 0.636694549043745 0.268838433743378 no 948 0.262161912428972 1308 723597
SGTC_204 PMA1.184 62.41 µM 0.635765659137835 0.269137116640356 no 949 0.262464586724874 1304 2252213 YGL008C PMA1
SGTC_1792 st045773 43.6 µM 0.633239701465181 0.269950174922569 no 950 0.26328856159203 1251 2919270
SGTC_3167 9103034 49.47 µM 0.63293158674063 0.270049435315675 no 951 0.263389159850287 1297 5127859
SGTC_2436 5633522 8.09 µM 0.632571785066981 0.270165369975179 no 952 0.263506658529017 1279 5724242
SGTC_2666 tannic acid 100 µM 0.632133328604355 0.270306682285189 no 953 0.263649879272928 1310 16134267 A thiamine antagonist.
SGTC_1123 mangostin 811.285 nM 0.631935257687772 0.270370531659215 no 954 0.263714591678503 1295 5281650 An antioxidant.
SGTC_1429 4049-0205 9.46 µM 0.630564920289965 0.270812474706253 no 955 0.264162520951232 1322 22774478
SGTC_1755 st041960 45.185 µM 0.630525208472003 0.27082528740946 no 956 0.264175507534298 1308 2257073
SGTC_2051 5263410 176 µM 0.627921305124365 0.271666075967463 no 957 0.265027746725644 1341 227584
SGTC_517 1365-0151 113 µM 0.626219406702946 0.272216312584373 no 958 0.265585519911838 1340 768657
SGTC_128 0906-2981 13.371 µM 0.626124720946613 0.272246941461515 no 959 0.265616569306741 1323 6740226
SGTC_1762 st045503 25.4615 µM 0.619892993862828 0.274266533202956 no 960 0.267664119341473 1315 4645554
SGTC_524 r073-0010 27.8 µM 0.618804256469749 0.274620131257148 no 961 0.268022658909653 1261 2772106
SGTC_2885 9057732 51.95 µM 0.617376213880949 0.275084268836883 no 962 0.268493303682374 1302 6471414
SGTC_778 3456-2434 196 µM 0.615988690024844 0.275535606908988 no 963 0.268950992187481 1359 5539063
SGTC_1677 st019204 53.9 µM 0.614799325842884 0.275922776659343 no 964 0.269343627286812 1280 3945625
SGTC_1902 st060212 70.5 µM 0.614433729131312 0.27604184181071 no 965 0.269464376475109 1329 688944
SGTC_2824 7998404 51.95 µM 0.60978226307907 0.277558899460144 no 966 0.271003026236596 1325 837851
SGTC_247 mechlorethamine 29.705 µM 0.606314732258711 0.27869246546835 no 967 0.27215288879959 1259 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1529 apigenin 74 µM 0.606229581834227 0.278720330213007 no 968 0.272181155880098 1428 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_501 nsc-95397 161 µM 0.605918758315722 0.278822056048226 no 969 0.272284351230824 1368 262093
SGTC_2698 st077697 67.5 µM 0.601227998118239 0.280359430675319 no 970 0.273844069379291 1272 3154499
SGTC_2790 5423970 71.43 µM 0.598085387826138 0.281391697448521 no 971 0.274891479836045 1408 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2179 6298986 200 µM 0.597792068759412 0.281488138740663 no 972 0.274989341714848 1371 738374
SGTC_1253 0550-0034 176 µM 0.596439669130262 0.281933004580969 no 973 0.275440773164765 1339 5969915
SGTC_880 0833-0487 87.2 µM 0.595051253157451 0.282390069892926 no 974 0.275904605841237 1307 76075
SGTC_1964 st076914 61 µM 0.593466781642251 0.282912111595165 no 975 0.276434403793155 1341 24208661
SGTC_983 1491-0821 12.2 µM 0.591760679717939 0.28347474494158 no 976 0.277005428422307 1359 46495113
SGTC_2037 5169046 200 µM 0.59144747024591 0.283578092487728 no 977 0.277110320918488 1367 5718022
SGTC_1591 genipin 88.4 µM 0.58883792637233 0.284439846510644 no 978 0.277985000654748 1397 442424 A DNA cross-linking agent.
SGTC_634 1611-4317 11.2 µM 0.588176995625979 0.284658305173984 no 979 0.278206748300046 1378 2843522
SGTC_2197 6588183 93.1375 µM 0.587800520263571 0.284782778070167 no 980 0.278333097396137 1333 884136
SGTC_2076 5212012 200 µM 0.582556694232467 0.286519222967373 no 981 0.280095882674572 1300 604802
SGTC_1772 st048439 82.2 µM 0.582548627783664 0.28652189796298 no 982 0.280098598486609 1344 2927068 YDL195W SEC31
SGTC_3025 9087895 49.47 µM 0.580032367631049 0.287356917854462 no 983 0.28094639528499 1376 17173641
SGTC_322 k048-0136 19.3 µM 0.57702980841382 0.288354819802298 no 984 0.281959659590022 1366 6823282
SGTC_2657 nystatin 74.44 µM 0.573916740509329 0.289391171310573 no 985 0.28301207209908 1388 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_654 1124-0271 80.9 µM 0.572702033360667 0.289796025765953 no 986 0.283423230233494 1353 5403748
SGTC_2068 5226020 147 µM 0.57177856623727 0.290103989389308 no 987 0.283735999941179 1361 1810509
SGTC_488 nitrendipine 139 µM 0.571043951244669 0.29034908289911 no 988 0.283984925173788 1423 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3270 9137563 49.47 µM 0.570780417688611 0.290437030626911 no 989 0.284074249316905 1397 17015724
SGTC_2801 7907800 81.82 µM 0.567236801906783 0.291620833114414 no 990 0.285276653847163 1395 6620925
SGTC_1933 st074711 15.9 µM 0.566297957833137 0.29193484577107 no 991 0.285595624218959 1348 17250958
SGTC_2419 paclitaxel 166.5 µM 0.566155544874794 0.29198249200178 no 992 0.285644023554913 1314 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3098 9119039 49.47 µM 0.56595887012562 0.292048298219583 no 993 0.285710870287763 1412 17161528
SGTC_2593 nobiletin 86.24 µM 0.565219830660309 0.292295638184417 no 994 0.285962124975754 1341 72344 An anti-infammatory.
SGTC_3004 9076122 71.4286 µM 0.565102400665465 0.292334948343566 no 995 0.286002057865572 1430 44782551
SGTC_1461 k072-0203 53.8 µM 0.564619936517779 0.292496480936287 no 996 0.286166150974322 1330 5418714
SGTC_502 l-744,832 89.3 µM 0.559187439096887 0.294318178166818 no 997 0.288016902351732 1388 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1831 st055328 12 µM 0.559185078876483 0.294318970764805 no 998 0.288017707661587 1437 1103068
SGTC_2331 7980721 200 µM 0.557035609893379 0.295041204058404 no 999 0.288751549746288 1433 2981221
SGTC_1975 st070967 30.8 µM 0.556271285652353 0.295298217784081 no 1000 0.289012706813896 1435 261391
SGTC_2658 polymyxin b sulfate 77.05 µM 0.556082375450223 0.295361757113549 no 1001 0.289077271455251 1379 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2905 7799065 20.05 µM 0.556081090340349 0.295362189377598 no 1002 0.289077710695935 1421 1296806
SGTC_677 0929-0063 136 µM 0.55586727166368 0.295434114227844 no 1003 0.289150796647781 1377 1539583
SGTC_2653 dihydrofissinolide 100 µM 0.554910338082787 0.295756108558462 no 1004 0.289477995161963 1419 6857746
SGTC_2931 9014674 55.67 µM 0.554360953366084 0.295941041410677 no 1005 0.289665921499314 1373 2996810
SGTC_2896 9052656 71.43 µM 0.55104363779727 0.297058836454672 no 1006 0.290801880384272 1360 6469436
SGTC_2173 5763948 167 µM 0.549121713454038 0.297707325771837 no 1007 0.2914609624844 1412 2867177
SGTC_578 3460-0051 92 µM 0.547211847819831 0.298352385365982 no 1008 0.29211659872297 1448 2876744
SGTC_2114 5491910 81.25 µM 0.546635831770422 0.298547060337238 no 1009 0.292314473449804 1490 2849228
SGTC_181 1447-1644 8.07 µM 0.545869391439158 0.298806182165524 no 1010 0.292577859898761 1400 534600
SGTC_2249 haloperidol 116.36 µM 0.544834403405875 0.29915625799061 no 1011 0.292933707386208 1432 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_810 3825-7150 143 µM 0.543733226729949 0.299528925806137 no 1012 0.293312532094888 1497 22330411 YGL099W LSG1
SGTC_1712 st032288 53.4 µM 0.54273445923276 0.29986711745904 no 1013 0.293656322419283 1394 2883011
SGTC_967 1306-0166 352 µM 0.540538819641331 0.300611187747112 no 1014 0.294412748539862 1469 4437607
SGTC_1156 4092-0367 4.88 µM 0.540402403960447 0.300657444525365 no 1015 0.294459775164662 1426 1357585
SGTC_933 2914-0560 114 µM 0.539853809068332 0.300843498329507 no 1016 0.294648927470189 1539 463887
SGTC_834 0312-0008 75.7 µM 0.538990802850801 0.301136288559395 no 1017 0.294946600339137 1436 6385573 YIL048W NEO1
SGTC_362 0310-0100 9.03 µM 0.53862066298132 0.301261904433668 no 1018 0.295074313473837 1434 790235
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.5374501635675 0.301659296806996 no 1019 0.295478350353222 1393 689007
SGTC_1830 st055982 50.3 µM 0.53718140876488 0.301750574125891 no 1020 0.295571155935062 1438 455313 An antimicrobial agent.
SGTC_2595 hexamethylquercetagetin 100 µM 0.536694984985286 0.301915810026012 no 1021 0.295739160367829 1435 386331
SGTC_486 niguldipine 82 µM 0.536130834309516 0.302107500290235 no 1022 0.295934065594621 1429 1236 A calcium channel blocker.
SGTC_2851 9015922 71.43 µM 0.531550401342443 0.303665883795591 no 1023 0.297518712273706 1486 2996893
SGTC_1208 2323-2347 50.3 µM 0.531352206406102 0.303733395839474 no 1024 0.297587367159189 1454 5412760
SGTC_3315 9136395 68.55 µM 0.530644152634084 0.303974638109217 no 1025 0.29783269659872 1475 16876844
SGTC_154 3389-1638 511.116 µM 0.527299605327531 0.305115317714455 no 1026 0.298992774149273 1330 5238686
SGTC_52 0329-0193 875 nM 0.52652703113257 0.305379079109036 no 1027 0.299261037909315 1518 3739292
SGTC_404 fumagillin 50 µM 0.523991692028831 0.306245368376145 no 1028 0.300142159164641 1450 12015870 A methionine aminopeptidase binder.
SGTC_1105 epirubicin 18.1 µM 0.52382243473926 0.306303239845656 no 1029 0.300201023897075 1393 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2463 5473429 200 µM 0.523352823436045 0.306463831916993 no 1030 0.30036437384113 1453 5399405
SGTC_2363 9053361 176 µM 0.520056591644695 0.307592082814714 no 1031 0.301512066072696 1560 6469797 YMR079W SEC14
SGTC_290 2043-6722 48.1 µM 0.518429929818072 0.308149537174732 no 1032 0.302079168445492 1478 773758 YLR208W SEC13
SGTC_1784 st039334 36.3 µM 0.518347540289505 0.308177783725331 no 1033 0.302107904608785 1532 3496984
SGTC_2684 capsaicin 100 µM 0.518110546428391 0.308259041392704 no 1034 0.30219057115767 1430 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1487 3970-0795 2.82 µM 0.517565858544636 0.30844583317891 no 1035 0.302380603864019 1485 3765103
SGTC_2056 5235370 200 µM 0.517261946113207 0.308550076527765 no 1036 0.302486657238076 1429 5511916
SGTC_2342 7990637 118.86 µM 0.517064034737542 0.308617969329718 no 1037 0.302555729416302 1495 2033102 YER133W GLC7
SGTC_2128 5255449 168.493 µM 0.516569872975006 0.308787518346946 no 1038 0.302728225493538 1412 736008
SGTC_1085 doxorubicin 7.67 µM 0.516054094228198 0.308964527720806 no 1039 0.302908314338949 1545 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2101 5377231 179.231 µM 0.515672236710991 0.309095605447865 no 1040 0.303041674254742 1542 2844213
SGTC_3101 9120531 49.47 µM 0.515172670745912 0.309267124883727 no 1041 0.303216182319656 1510 24824904
SGTC_1388 3346-4487 254 µM 0.514085799202194 0.309640431581275 no 1042 0.303596002720239 1509 3345614
SGTC_2100 5377183 190 µM 0.514065221019721 0.309647501445477 no 1043 0.303603196063584 1553 2844202
SGTC_1399 3562-5772 25 µM 0.513707469733969 0.309770422144882 no 1044 0.303728264350982 1425 23847490
SGTC_675 1309-0189 238 µM 0.513499157231113 0.309842006583591 no 1045 0.303801100082579 1418 4246530
SGTC_2343 7990716 14.84 µM 0.512949856085803 0.310030802817154 no 1046 0.303993198644913 1498 6456862
SGTC_2816 7982706 58.44 µM 0.512641126570323 0.310136935950006 no 1047 0.304101189591425 1440 2981853
SGTC_625 k213-0058 121 µM 0.512018886112212 0.310350894008587 no 1048 0.304318895921274 1533 3655420
SGTC_1480 1070-0044 41.2 µM 0.511163628763708 0.310645079929649 no 1049 0.304618242208049 1495 3124987
SGTC_42 0133-0086 60.653 µM 0.511129790606553 0.31065672185337 no 1050 0.304630088501894 1371 162923 Model of phenazepam hydroxylation.
SGTC_2085 5307070 144.047 µM 0.510845049220908 0.31075469384376 no 1051 0.30472978083179 1410 2840351
SGTC_2841 9004761 38.96 µM 0.509926836029934 0.311070718137973 no 1052 0.305051360120173 1354 2991039
SGTC_338 4055-0136 114 µM 0.50938803062926 0.311256225365826 no 1053 0.305240132240713 1428 2900563
SGTC_1355 1499-0035 1.68 µM 0.507932233884409 0.311757686488182 no 1054 0.30575043411295 1444 1548538
SGTC_878 0828-0289 13.7 µM 0.506732183471244 0.31217131634618 no 1055 0.306171372840622 1463 745350 YLR208W SEC13
SGTC_1080 nisoldipine 24.4 µM 0.5030411278575 0.313445021615038 no 1056 0.307467678304544 1463 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1277 0873-0036 22 µM 0.502612348776186 0.313593128935353 no 1057 0.30761842273977 1577 5965735
SGTC_1953 st076800 12.1 µM 0.501131086105493 0.314105012464176 no 1058 0.30813943519451 1429 297591
SGTC_2472 5377652 49.4 µM 0.501049872576335 0.314133087975944 no 1059 0.308168012059695 1460 1610903
SGTC_1602 st001878 87.6 µM 0.500990816308657 0.31415350439933 no 1060 0.308188793108429 1504 595405 YLR310C CDC25
SGTC_922 1866-0035 480 µM 0.49885770109294 0.314891327445923 no 1061 0.308939817346162 1538 3156169
SGTC_2990 9074105 71.4286 µM 0.498475215768428 0.315023703525655 no 1062 0.309074566863662 1495 6502001
SGTC_2047 4141938 200 µM 0.497446552244531 0.315379836201996 no 1063 0.309437092285738 1499 3807862
SGTC_873 0591-4978 488 µM 0.497292569813389 0.315433161094587 no 1064 0.309491375320258 1631 3305145
SGTC_377 3970-0964 33.1 µM 0.497169209295325 0.315475884237838 no 1065 0.309534866288807 1523 16481235
SGTC_3341 9147222 25.867 µM 0.496890374212973 0.315572461591493 no 1066 0.309633179917536 1479 1939759
SGTC_1025 k007-0731 70 µM 0.496547390958212 0.315691274592163 no 1067 0.309754130041863 1465 6256118
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.496196180013455 0.315812957492885 no 1068 0.309878002938573 1471 2724 A muscle relaxant with antifungal properties.
SGTC_2533 agelasine 13.65 µM 0.494921088974203 0.316254901830219 no 1069 0.310327911827833 1636 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3161 9100388 49.47 µM 0.49328066809563 0.316823855061946 no 1070 0.310907143002988 1563 25236368
SGTC_572 0960-0087 17.7 µM 0.492506307039745 0.31709258027275 no 1071 0.311180732199389 1431 6796365
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.490829705261882 0.317674739034082 no 1072 0.31177344913168 1576 688761
SGTC_2622 2-methoxyxanthone 59.94 µM 0.488977936384482 0.318318244520956 no 1073 0.312428658671488 1631 71034 A hepatoprotective.
SGTC_901 1112-0062 60.1 µM 0.488907008395475 0.318342903523812 no 1074 0.312453766864783 1502 1908457
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.488417092790661 0.318513250790122 no 1075 0.31262721858665 1395 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_168 3970-0862 530.542 µM 0.487608496274438 0.318794489675125 no 1076 0.312913588177148 1515 3135186
SGTC_1325 1431-0015 227 µM 0.487592917844399 0.318799909052248 no 1077 0.312919106486352 1413 1103340
SGTC_1185 1319-0113 81.3 µM 0.486498096486609 0.319180869188401 no 1078 0.313307027308063 1541 4672763
SGTC_3333 9141820 12.094 µM 0.485635326853803 0.319481217923868 no 1079 0.313612872399552 1493 1939433
SGTC_3248 9135562 49.47 µM 0.484778005071531 0.319779787498437 no 1080 0.313916913232833 1514 17650701
SGTC_81 0411-0046 9.971 µM 0.48455713835876 0.319856725133359 no 1081 0.313995261946245 1434 12925265
SGTC_2665 lovastatin 100 µM 0.483797550412397 0.320121382322072 no 1082 0.314264776854871 1484 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_68 0986-0284 82.829 µM 0.483644628293967 0.320174674835179 no 1083 0.314319048243862 1441 423278 YIL048W NEO1
SGTC_988 1497-1057 103 µM 0.482459084475542 0.320587956102216 no 1084 0.314739928657712 1564 3533044
SGTC_1356 1502-0781 85.8 µM 0.482162850805555 0.320691258100615 no 1085 0.314845132318468 1494 567702
SGTC_895 0964-0006 13.7 µM 0.479832098724013 0.321504517155258 no 1086 0.31567339328666 1491 6738897
SGTC_3154 9100113 49.47 µM 0.479601291616121 0.321585098321246 no 1087 0.315755463877611 1459 25237525
SGTC_1828 st055811 49 µM 0.477343053418817 0.322373954354644 no 1088 0.316558928956154 1552 5877589
SGTC_816 0325-0417 81.3 µM 0.477076986857573 0.322466950483288 no 1089 0.316653650670549 1492 68101
SGTC_2721 ifenprodil 61.44 µM 0.476872966065557 0.32253826777375 no 1090 0.316726291765778 1581 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.476852352957871 0.322545473632942 no 1091 0.316733631404622 1561 5393153
SGTC_2145 5634607 200 µM 0.475895082515364 0.322880186325824 no 1092 0.317074562852134 1474 308662
SGTC_245 methotrexate 289.6 µM 0.474298976278872 0.323438589062359 no 1093 0.317643360720537 1550 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_554 4483-2211 187 µM 0.473348743306885 0.32377122007762 no 1094 0.317982196004324 1521 747107
SGTC_1943 st076331 65.2 µM 0.473232744055015 0.323811835504644 no 1095 0.318023569610437 1547 24208415
SGTC_397 arbidol 50 µM 0.472675808727754 0.324006867406918 no 1096 0.318222244090564 1594 131410 A RNA synthesis inhibitor.
SGTC_2147 5545932 89.7195 µM 0.470457994741609 0.324783997474137 no 1097 0.319013919075342 1534 797404
SGTC_2998 9066762 71.4286 µM 0.469446811270844 0.325138573373047 no 1098 0.319375147487951 1620 4945196
SGTC_2323 6148992 148.28 µM 0.468112687941686 0.325606631881952 no 1099 0.319852003152452 1479 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2079 5212404 121 µM 0.467105574859083 0.32596014569204 no 1100 0.320212172909201 1620 758462
SGTC_598 3937-0236 20.2 µM 0.466679210832511 0.326109853883926 no 1101 0.320364702819735 1566 1379313
SGTC_2618 avocadyne 43.43 µM 0.464931933659822 0.326723663777652 no 1102 0.32099010060615 1577 3015189
SGTC_1735 st034310 56.75 µM 0.464391507291844 0.326913608006293 no 1103 0.321183636810656 1624 871153
SGTC_189 3970-0742 2.116 µM 0.464144778343564 0.327000341008401 no 1104 0.321272010948567 1575 2891807
SGTC_626 0214-0009 33 µM 0.464118510404655 0.327009575567411 no 1105 0.32128142027638 1624 3437874
SGTC_2934 9036370 36.88 µM 0.463645822842451 0.327175768149744 no 1106 0.321450759298314 1651 6462800
SGTC_1404 3909-7820 48.3 µM 0.463641347809012 0.327177341693993 no 1107 0.321452362644167 1611 23741373
SGTC_573 3702-0553 84.7 µM 0.462467074638903 0.32759035436882 no 1108 0.321873204227792 1518 1222756
SGTC_2842 9000675 19.48 µM 0.462458140152235 0.327593497595696 no 1109 0.321876407088335 1459 2989072
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.461481118428985 0.32793729566664 no 1110 0.322226732458875 1714 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_202 3594-0513 34.79 µM 0.460010087938314 0.328455202464841 no 1111 0.322754489795631 1541 708429
SGTC_2464 5717415 7.67 µM 0.45859254846566 0.328954588696638 no 1112 0.323263394324133 1459 5285744
SGTC_2214 7179297 48.276 µM 0.458153724238285 0.329109244432007 no 1113 0.323421001771956 1600 769744
SGTC_641 4092-0595 30 µM 0.457351283412201 0.329392125963461 no 1114 0.323709287149429 1579 786260
SGTC_2929 9013348 24.6 µM 0.456338538364759 0.329749284693763 no 1115 0.324073277583963 1544 2995952
SGTC_2426 5582046 32.21 µM 0.454534712111823 0.330385813787217 no 1116 0.324722006856032 1572 2251934
SGTC_2673 kobusone 100 µM 0.449947355615426 0.332006796140507 no 1117 0.326374200232789 1607 6710676 An epoxy ketone and protein crosslinker.
SGTC_750 4073-0104 132 µM 0.449876749859691 0.332031769982101 no 1118 0.326399656518778 1459 22330957
SGTC_2305 7443522 69.23 µM 0.449759774699312 0.332073146708901 no 1119 0.326441832666425 1620 5415886
SGTC_1104 tacrolimus 29.8 µM 0.448460910873224 0.332532721351306 no 1120 0.326910295394224 1555 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1777 st045864 34.765 µM 0.448360670801206 0.332568199591322 no 1121 0.32694646045124 1551 4691462
SGTC_2136 5328288 199.296 µM 0.447250885366495 0.332961089112446 no 1122 0.327346962303707 1529 262395
SGTC_1310 1188-0297 994 nM 0.447033457214254 0.333038085174408 no 1123 0.327425451568875 1546 1588352
SGTC_3012 9080433 71.4286 µM 0.445953698980931 0.333420555392699 no 1124 0.327815345841791 1660 17688859
SGTC_516 3992-2719 87.3 µM 0.443873239650322 0.334157980551645 no 1125 0.328567116502443 1461 5350887 YDR037W KRS1
SGTC_684 1140-0066 328 µM 0.442662916761141 0.334587278153474 no 1126 0.329004784478213 1551 6813534
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.442363873671174 0.334693381119505 no 1127 0.329112958375031 1600 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1068 loratadine 26.9 µM 0.440372965649043 0.335400107928309 no 1128 0.329833500873979 1546 3957 A H1 histamine antagonist.
SGTC_2911 7942208 15.64 µM 0.440136651047848 0.3354840329519 no 1129 0.329919069037286 1535 1243384
SGTC_523 1934-0222 13.7 µM 0.439145630895692 0.335836074281756 no 1130 0.330278008639962 1544 1361595
SGTC_1383 3049-0032 20.7 µM 0.438005580080876 0.336241234185706 no 1131 0.3306911192 1673 712864
SGTC_3146 9095609 49.47 µM 0.437594398843796 0.336387409607455 no 1132 0.330840166116042 1634 17173999
SGTC_1211 1056-0033 32.3 µM 0.4372219649511 0.33651983165087 no 1133 0.330975190860797 1620 6741922
SGTC_532 1548-0774 215 µM 0.436929241883353 0.336623926064846 no 1134 0.331081332128726 1679 5932993
SGTC_1864 st057645 30.4 µM 0.434209780315606 0.33759158355789 no 1135 0.33206805577272 1612 688666
SGTC_2478 5763493 32.33 µM 0.433846963935648 0.337720764773989 no 1136 0.33219978756968 1626 1365576 YLR208W SEC13
SGTC_2624 nerol 100 µM 0.431200084684687 0.33866376710867 no 1137 0.333161446181023 1665 637566 A natural product oil.
SGTC_3284 9108171 64.8615 µM 0.430616169023466 0.338871934946006 no 1138 0.333373741242198 1595 8687505
SGTC_3141 9094609 49.47 µM 0.429745567342616 0.33918239866618 no 1139 0.333690366274765 1523 25236309 YDL196W YDL196W
SGTC_3241 9133421 49.47 µM 0.428913360726567 0.33947927250223 no 1140 0.333993138350001 1608 17018221
SGTC_1978 st071761 42 µM 0.427529700501769 0.339973087380457 no 1141 0.334496778570898 1530 5147680
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.425771795536672 0.340600862684607 no 1142 0.335137070332087 1576 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2983 9022671 12.99 µM 0.423780817162726 0.341312405709772 no 1143 0.335862834640685 1726 6405161
SGTC_2123 5259487 200 µM 0.423446623749246 0.341431896355639 no 1144 0.335984717093475 1699 2173474
SGTC_648 0375-0473 33.3 µM 0.422026418736564 0.341939866966374 no 1145 0.336502867121584 1617 1713139
SGTC_1641 st009299 47.1 µM 0.421739418856894 0.342042554200527 no 1146 0.336607614408917 1618 4046054
SGTC_1721 st082152 9.2685 µM 0.421274036543202 0.342209090679286 no 1147 0.336777493464547 1531 5296051
SGTC_1574 spiramycin 23.7 µM 0.42122296664518 0.342227367847897 no 1148 0.336796137598448 1528 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2491 paeonol 100 µM 0.419849347357432 0.342719104612557 no 1149 0.337297756375857 1569 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3100 9120536 49.47 µM 0.419308838704715 0.342912672402147 no 1150 0.337495218895977 1625 16421196
SGTC_2175 5807670 165.306 µM 0.417473760414626 0.343570160887804 no 1151 0.338165956585441 1618 241186
SGTC_1825 st052143 62.6 µM 0.416889919805111 0.343779443989767 no 1152 0.338379463480578 1656 674173
SGTC_1449 4112-4002 201 µM 0.416627861577108 0.343873396774641 no 1153 0.338475313454872 1536 2059539
SGTC_472 calcifediol 10 µM 0.414582589508988 0.344606996016027 no 1154 0.339223747864646 1623 5283731 A vitamin D metabolite.
SGTC_270 tamoxifen 5.46 µM 0.414442876150087 0.344657129844415 no 1155 0.339274896916242 1739 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1889 st059080 5.18 µM 0.411690150848929 0.3456454552586 no 1156 0.340283272468753 1737 176925 Isolated from Daphnopsis sellowiana.
SGTC_1021 4476-0760 85.3 µM 0.411053424267637 0.345874212741337 no 1157 0.340516680566425 1569 746768
SGTC_2540 epiandrosterone 100 µM 0.409297211592546 0.346505460702675 no 1158 0.341160780792422 1624 441302 A steroid.
SGTC_1842 st055362 61.2 µM 0.408657485550364 0.346735508035558 no 1159 0.341395518849656 1666 676032
SGTC_1269 0831-0796 3.05 µM 0.408631492386645 0.346744856447808 no 1160 0.341405057956675 1694 927758
SGTC_2589 lobaric acid 100 µM 0.407132027351423 0.34728429515854 no 1161 0.341955510807164 1562 73157 A novel microtubule depolymerizer.
SGTC_1066 ketoconazole 628 nM 0.406813711171668 0.347398850576735 no 1162 0.342072407803037 1695 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1810 st050138 53 µM 0.405044862006766 0.348035676564793 no 1163 0.342722267500697 1715 3444541
SGTC_2734 clemastine 41.6 µM 0.402351826612131 0.349006053625165 no 1164 0.343712558930337 1653 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1204 4049-0315 18.3 µM 0.401104643097299 0.349455784447378 no 1165 0.344171541266043 1729 588402
SGTC_647 0140-0236 81 µM 0.400936468490239 0.349516443921 no 1166 0.344233449642326 1668 990837
SGTC_80 0159-0065 512.242 µM 0.400369781824974 0.349720872354378 no 1167 0.344442088859066 1654 1548079
SGTC_2563 tomatine 8.54 µM 0.398797690267644 0.350288221884889 no 1168 0.345021139544339 1873 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_272 doxorubicin 8.13 µM 0.398352364232917 0.350448995668814 no 1169 0.345185233162907 1633 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1587 estradiol valerate 56.1 µM 0.397539312507781 0.35074259668615 no 1170 0.345484901322741 1752 13791 A steroid.
SGTC_1479 0549-0158 134 µM 0.394478695088201 0.351848614185564 no 1171 0.346613826758931 1639 5440202
SGTC_2612 dictamnine 15.46 µM 0.394198919853845 0.351949779498491 no 1172 0.346717091548594 1640 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_772 k072-0172 35.3 µM 0.393492243110844 0.352205356901246 no 1173 0.346977976005654 1530 5861980
SGTC_1892 st058411 7.36 µM 0.392414605520438 0.352595224872878 no 1174 0.34737594803985 1715 3934738
SGTC_2458 5808907 16.39 µM 0.391263104836177 0.353011986227304 no 1175 0.347801383769226 1717 2731747
SGTC_2575 plumbagin 510 nM 0.389431831345173 0.353675140167214 no 1176 0.348478364409372 1570 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_14 0354-0009 295 µM 0.389131483790572 0.353783946649762 no 1177 0.348589442300664 1692 1713507
SGTC_1320 1313-0481 95.3 µM 0.388821710503782 0.353896180291833 no 1178 0.348704019722053 1763 6813365 YLR208W SEC13
SGTC_970 1315-0089 19.5 µM 0.388455542424758 0.354028862647925 no 1179 0.348839473970214 1563 6811083 YLR033W RSC58
SGTC_2160 5660466 132.927 µM 0.385898098796007 0.354956055263398 no 1180 0.349786069358848 1739 2859134
SGTC_1552 6-methylflavone 10.6 µM 0.385765306737875 0.355004222102517 no 1181 0.349835245710319 1741 689013
SGTC_2821 7996764 71.43 µM 0.384458698225015 0.35547828356963 no 1182 0.350319251039153 1677 2987135
SGTC_285 1486-1325 46 µM 0.382829737408459 0.35606961355588 no 1183 0.35092300543401 1709 22310230
SGTC_3078 9116413 49.47 µM 0.382333022429286 0.356249995317974 no 1184 0.351107181757932 1605 17177322
SGTC_2174 5790901 200 µM 0.382290791968699 0.356265332770121 no 1185 0.351122841951405 1641 786020
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.381661491835029 0.356493912412963 no 1186 0.35135623335061 1647 6708784 An antioxidant flavonoid
SGTC_2836 9010338 19.48 µM 0.381364464518019 0.356601819068065 no 1187 0.351466412701254 1517 2994051
SGTC_2314 7727897 200 µM 0.380734686862382 0.356830648107649 no 1188 0.351700063781534 1599 900724
SGTC_1414 3917-0015 5.4 µM 0.371961971938698 0.36002352942723 no 1189 0.354960581557206 1719 6618702
SGTC_1400 3771-8998 51.5 µM 0.371627460414515 0.360145472045328 no 1190 0.355085120335323 1727 670767
SGTC_312 4092-0653 6.84 µM 0.37136224893171 0.360242162185679 no 1191 0.355183869683872 1740 1148278
SGTC_2245 6637752 200 µM 0.36934626715209 0.360977435655045 no 1192 0.355934821712993 1806 681890
SGTC_1780 st038448 24.544 µM 0.368468444332027 0.361297758006771 no 1193 0.356261985163381 1770 728868 YDL195W SEC31
SGTC_2526 patulin 37.61 µM 0.367438136666895 0.36167384698058 no 1194 0.356646114518131 1715 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.366935490265342 0.361857374464237 no 1195 0.356833568863345 1669 6857784
SGTC_1290 0986-0249 10.2 µM 0.366125062383227 0.362153346775683 no 1196 0.357135878439546 1721 53329
SGTC_2869 9037858 32.47 µM 0.363679700891015 0.363046904021399 no 1197 0.358048601602143 1628 27187042
SGTC_806 3966-4455 5.86 µM 0.363136016024206 0.363245672942102 no 1198 0.358251640710068 1629 714982
SGTC_2065 5221596 34.26 µM 0.362660825246907 0.363419430876884 no 1199 0.358429133535251 1706 788581
SGTC_318 1488-0629 67.2 µM 0.361232480938332 0.363941887355113 no 1200 0.358962831425019 1654 3662576
SGTC_984 1492-0255 2.91 µM 0.358929335706709 0.364784859080447 no 1201 0.359823976601424 1719 1585198
SGTC_1173 0443-0020 122 µM 0.358859691778106 0.364810359589076 no 1202 0.359850027554579 1662 5331295
SGTC_2479 5617353 43.85 µM 0.358697801899035 0.364869638772072 no 1203 0.359910586471012 1743 2731746
SGTC_2495 cafestol 54.53 µM 0.358037181215807 0.365111571581688 no 1204 0.360157744430339 1736 16667697 An anti-infammatory.
SGTC_1166 k206-0078 225 µM 0.356702494571151 0.365600524898174 no 1205 0.360657268918239 1650 5404595
SGTC_1191 1487-1166 10.6 µM 0.35665168033403 0.365619144668033 no 1206 0.360676291537679 1763 3955771
SGTC_1223 0764-0573 147 µM 0.356539786938764 0.3656601466806 no 1207 0.360718180727651 1682 1609797
SGTC_698 k064-0052 127 µM 0.35627451621464 0.365757358135083 no 1208 0.360817495998118 1740 5088751
SGTC_646 4092-0839 27.3 µM 0.355508405466585 0.366038156457824 no 1209 0.361104374508821 1777 877796
SGTC_3240 9133527 49.47 µM 0.354816092049926 0.366291967989153 no 1210 0.361363686025279 1687 17617455
SGTC_1980 st071811 45.7 µM 0.353013265469149 0.366953183064695 no 1211 0.362039247786286 1773 4974850
SGTC_2086 5274770 176.623 µM 0.351199686302324 0.367618740288768 no 1212 0.362719272725964 1687 689278
SGTC_1722 st034304 3.6505 µM 0.350494727938947 0.367877557246924 no 1213 0.362983723019975 1664 4036148 YLR033W RSC58
SGTC_1396 3511-0007 98.6 µM 0.350170673812765 0.367996549946024 no 1214 0.363105307036794 1695 X1396
SGTC_2634 4'-methoxyflavone 100 µM 0.349479977557831 0.368250215923793 no 1215 0.363364499976172 1687 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3247 9135149 49.47 µM 0.349471454670811 0.368253346409053 no 1216 0.363367698693724 1702 8934436 YOR116C RPO31
SGTC_581 0958-0271 211 µM 0.348457028642894 0.368626010949062 no 1217 0.363748490067572 1651 4591145
SGTC_2757 clomiphene 4.22 µM 0.347485828018129 0.368982911802917 no 1218 0.364113181803771 1846 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1258 0671-0043 57.1 µM 0.346096038926931 0.369493833773534 no 1219 0.364635270088745 1668 4298767
SGTC_1100 amiodarone 5.07 µM 0.345929237628486 0.369555169704967 no 1220 0.364697947578443 1864 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2729 fluphenazine 10.66 µM 0.344737063496551 0.36999365081837 no 1221 0.365146025810812 1648 3372 An atypical antipsychotic.
SGTC_271 rotenone 740 µM 0.343680895518616 0.370382250176623 no 1222 0.365543140066374 1776 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3036 9090181 49.47 µM 0.342375617062755 0.370862688348856 no 1223 0.366034117852657 1730 25236586
SGTC_2420 aureobasidin a 50 nM 0.342025944747036 0.370991427632042 no 1224 0.366165683671538 1852 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2780 5215298 71.43 µM 0.341667631926747 0.371123363080832 no 1225 0.366300516843805 1868 2834131
SGTC_2713 st079149 53.4 µM 0.341513270628848 0.371180205591559 no 1226 0.366358608113702 1730 3103253
SGTC_2424 5537928 59.2 µM 0.340804689297568 0.371441171947968 no 1227 0.366625310017541 1669 5382802
SGTC_1108 betulinic acid 729.144 nM 0.340062783862208 0.371714474718542 no 1228 0.366904623759022 1700 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1836 st055642 81 µM 0.338851101973624 0.372160972518458 no 1229 0.36736095117467 1656 8571
SGTC_1652 st011932 78 µM 0.338136017819763 0.372424557628499 no 1230 0.367630344567011 1801 1551076
SGTC_3159 9100096 49.47 µM 0.338102819686668 0.372436796149475 no 1231 0.367642852870944 1667 25236875
SGTC_941 3237-0776 460 µM 0.337148488750916 0.372788666119496 no 1232 0.368002483112238 1826 760008
SGTC_489 paxilline 115 µM 0.335986413740977 0.373217276440675 no 1233 0.368440555900604 1698 105008 A toxic potassium channel blocker.
SGTC_663 1486-0733 13.9 µM 0.335287011286854 0.373475314054052 no 1234 0.368704295376146 1743 722445 YPR165W RHO1
SGTC_1509 1326-1131 80 µM 0.335202270368668 0.373506582233265 no 1235 0.368736254751063 1828 768313
SGTC_3356 9151811 4.48 µM 0.334033282686389 0.373938006764803 no 1236 0.369177221870025 1712 1859254 YPR165W RHO1
SGTC_3220 9131269 49.47 µM 0.332937649782344 0.374342502540132 no 1237 0.369590674361447 1728 17722206
SGTC_1561 5-methoxyflavone 52.9 µM 0.332006212148455 0.374686488031529 no 1238 0.369942284105067 1818 94525
SGTC_1117 retinoic acid 1.10837 µM 0.331940258133994 0.374710849028085 no 1239 0.3699671853077 1878 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1908 st060353 56.5 µM 0.331013624802602 0.375053166251698 no 1240 0.370317097028939 1906 4227716
SGTC_2127 5253358 187.912 µM 0.32870208910124 0.37590752317381 no 1241 0.371190437563649 1688 20612
SGTC_882 0843-0131 351 µM 0.328307770969657 0.376053326313695 no 1242 0.371339484570818 1810 5425421
SGTC_1206 3978-0017 132 µM 0.328149905073408 0.376111703795697 no 1243 0.371399161189423 1813 3873677
SGTC_1485 3909-9022 254 µM 0.327313789281319 0.376420939628986 no 1244 0.371715282005459 1772 714516
SGTC_1250 0485-0349 40.2 µM 0.326065162536295 0.376882889502596 no 1245 0.372187527055341 1704 6842794 YDL195W SEC31
SGTC_2737 bleomycin 30.5 nM 0.32240332526884 0.378238660528233 no 1246 0.373573582705325 1749 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2802 7925815 54.55 µM 0.319692531715585 0.379243281563914 no 1247 0.374600710873819 1702 1262923
SGTC_3006 9075424 71.4286 µM 0.319239214110651 0.379411361052448 no 1248 0.374772561428602 1695 7465181
SGTC_2525 harmine 47.85 µM 0.319156759726131 0.379441935646712 no 1249 0.374803822169149 1813 5280953 A monoamine oxidase inhibitor
SGTC_963 1269-2853 151 µM 0.318905667859504 0.379535046702373 no 1250 0.374899023115405 1676 3668223
SGTC_1486 3970-0793 4.53 µM 0.318195420542529 0.379798461736356 no 1251 0.375168353135043 1860 2844330
SGTC_367 0335-0881 7.1 µM 0.3171895951859 0.380171595548626 no 1252 0.375549872228537 1834 23828853
SGTC_305 1682-2595 20.8 µM 0.316438113770141 0.380450447513377 no 1253 0.375834995727411 1792 226033
SGTC_3204 9114183 49.47 µM 0.315285981897635 0.380878089323738 no 1254 0.376272263739789 1680 17027248
SGTC_1171 0368-0077 21.4 µM 0.315116851058039 0.380940878619208 no 1255 0.376336467264641 1743 3239779
SGTC_193 1273-0060 1.558 µM 0.314653575916235 0.381112884118739 no 1256 0.376512348021266 1842 2847393 YHR072W ERG7
SGTC_1678 st019265 80.2 µM 0.314609669318358 0.381129187046433 no 1257 0.376529018335383 1909 5367020
SGTC_2718 lomofungin 53.02 µM 0.314194792361197 0.381283245126796 no 1258 0.376686548831625 1859 5351222 A RNA synthesis inhibitor.
SGTC_3346 9158254 43.5805 µM 0.313773686653847 0.381439635396812 no 1259 0.376846465410513 1748 17639500
SGTC_2402 5553605 200 µM 0.313227954778625 0.381642338141456 no 1260 0.377053740709697 1814 6758546
SGTC_2800 7887935 81.82 µM 0.313091691352311 0.38169295592076 no 1261 0.377105500670823 1794 2961002
SGTC_2122 5258151 111.688 µM 0.312613210701443 0.381870713162406 no 1262 0.377287270080349 1736 2173356
SGTC_92 0063-0024 660.874 µM 0.310945542370103 0.382490452281618 no 1263 0.37792101078868 1873 3594437
SGTC_2144 5628481 200 µM 0.307391291957692 0.383812286124027 no 1264 0.379272777784268 1771 2818399
SGTC_3099 9120367 49.47 µM 0.305945346569569 0.384350424586234 no 1265 0.37982312935488 1762 24824940
SGTC_1076 itraconazole 331 nM 0.305644933746231 0.384462257437693 no 1266 0.379937502206073 1797 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_43 0570-0105 72.5 µM 0.304451512077764 0.384906620152079 no 1267 0.380391964076053 1769 1114046 YDL195W SEC31
SGTC_515 4092-1064 102 µM 0.303422505158156 0.385289885540881 no 1268 0.380783948472711 1916 717353
SGTC_3052 9092717 49.47 µM 0.302283171551805 0.385714374089894 no 1269 0.381218102907554 1755 25237534
SGTC_827 3253-0474 693 µM 0.301639202725566 0.385954362120365 no 1270 0.381463559836654 1908 5402065
SGTC_3229 9132204 49.47 µM 0.300397553237499 0.38641721111015 no 1271 0.381936964895573 1831 17682924
SGTC_2418 pentamidine 31.67 µM 0.30036990467677 0.3864275194911 no 1272 0.381947508505137 1744 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1729 st035615 45.989 µM 0.298182818198053 0.387243197615015 no 1273 0.382781817371487 1749 17385451
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.297405142844021 0.387533353372253 no 1274 0.38307860890078 1813 97141
SGTC_931 2812-0076 566 µM 0.296110179894818 0.388016651856366 no 1275 0.383572969995608 1752 3450959
SGTC_2552 juarezic acid 87.02 µM 0.295980284485404 0.388065140246742 no 1276 0.383622568945406 1801 1549512
SGTC_2667 digitoxin 100 µM 0.293742791651683 0.388900642665577 no 1277 0.384477226493667 1903 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2210 7115885 190.385 µM 0.293171181494712 0.389114170266364 no 1278 0.384695655307827 1817 2927039
SGTC_1229 0139-0193 12.2 µM 0.29308839838402 0.389145097055826 no 1279 0.384727292170882 1901 3090752
SGTC_1297 1068-0111 14.1 µM 0.293075860636201 0.389149781071127 no 1280 0.384732083734629 1725 767057
SGTC_429 1112-0049 25.5 µM 0.292443303003246 0.389386121094055 no 1281 0.384973851761775 1732 2836170
SGTC_930 2810-3379 265 µM 0.292314448898668 0.389434269366554 no 1282 0.385023106203688 1932 1015764
SGTC_180 1486-1293 102.781 µM 0.292285760942784 0.389444989283414 no 1283 0.385034072418549 1954 4140536
SGTC_2450 5739737 12.93 µM 0.289712114339362 0.390407033121102 no 1284 0.386018243856413 1802 2262825
SGTC_1530 rhein 70.4 µM 0.288279623367616 0.390942797700327 no 1285 0.386566351790984 1837 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2484 5809818 12.04 µM 0.288206240408491 0.390970249174458 no 1286 0.386594436105463 1784 2870548
SGTC_49 0717-0965 32.132 µM 0.288127670302406 0.390999641685387 no 1287 0.386624506245886 1881 5889349 YGL099W LSG1
SGTC_952 1185-0122 232 µM 0.288020479462476 0.391039742010878 no 1288 0.386665531134693 1786 678600
SGTC_2296 7971656 126.45 µM 0.287674144655056 0.391169314529091 no 1289 0.386798091666294 1776 666570
SGTC_1231 0242-0792 125 µM 0.286753461802773 0.391513823727505 no 1290 0.387150549563819 1758 3707635
SGTC_2228 7354201 200 µM 0.286564285844709 0.391584621798747 no 1291 0.3872229818678 1889 753451
SGTC_85 0868-0259 160.055 µM 0.286404944182221 0.391644257333857 no 1292 0.38728399416675 1825 83173
SGTC_2900 5328528 85.29 µM 0.285820532962871 0.391863002053691 no 1293 0.387507790426194 1754 795359
SGTC_1630 st005209 31.3 µM 0.285282037114326 0.392064590948087 no 1294 0.387714036806448 1953 3367314
SGTC_1178 0988-0033 191 µM 0.281940667497545 0.393316096841002 no 1295 0.38899450287444 1857 5392207
SGTC_2703 st077852 53.4 µM 0.281273994950499 0.393565930651564 no 1296 0.389250127253235 1824 6281836
SGTC_3138 9097216 49.47 µM 0.281110301590142 0.3936272810197 no 1297 0.389312900054411 1973 25237486
SGTC_3028 9087778 49.47 µM 0.279967736878904 0.394055574451348 no 1298 0.38975112883636 1753 17217395
SGTC_1276 0871-0068 94.2 µM 0.278835010657833 0.39448030641156 no 1299 0.390185722481236 1890 3414906
SGTC_571 k831-0106 44.2 µM 0.27765262367948 0.394923793235346 no 1300 0.390639515931611 1941 4783639
SGTC_2102 5377816 72.7585 µM 0.275373594511864 0.395778989673716 no 1301 0.391514614338252 1933 1379702
SGTC_2771 fluoxetine 41.05 µM 0.274732546141007 0.396019631104769 no 1302 0.391760862365994 1901 3386 A selective serotonin reuptake inhibitor.
SGTC_3203 9113543 49.47 µM 0.274257284255493 0.396198063979131 no 1303 0.391943454286255 1851 17018012
SGTC_274 sirtinol 40.1 µM 0.273912173363607 0.396327646445298 no 1304 0.392076058125918 1761 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2588 indole-3-carbinol 100 µM 0.273705419658438 0.396405283950765 no 1305 0.392155506234902 1951 3712 Induces cell cycle arrest.
SGTC_1829 berberine 14.4 µM 0.273299715545076 0.39655764070421 no 1306 0.392311416987109 1932 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1306 1185-0270 9.02 µM 0.272347866933361 0.396915156683522 no 1307 0.392677277087939 1912 1548076
SGTC_2753 fluvastatin 17.09 µM 0.270943490553738 0.397442801044554 no 1308 0.393217247490835 1839 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1443 4112-3303 14 µM 0.269938502826385 0.397820504648528 no 1309 0.393603782664804 1815 704433
SGTC_2964 9083345 53.42 µM 0.268665631147654 0.398299024289958 no 1310 0.394093500997094 1776 17741579
SGTC_390 dec-rvkr-cmk 16.7 µM 0.268363449820792 0.398412647947284 no 1311 0.39420978537112 1871 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1158 4092-0494 91.8 µM 0.267000112867401 0.398925385290976 no 1312 0.394734537094313 1912 1148199
SGTC_1699 st031318 29.054 µM 0.265435378085044 0.399514081325077 no 1313 0.395337042747664 1915 5340658
SGTC_1740 st038286 13.222 µM 0.264379473636047 0.399911470698285 no 1314 0.395743763333231 1868 716786
SGTC_497 capsazepine 133 µM 0.26406464142244 0.400029977806347 no 1315 0.395865054580643 1741 2733484 A calcium channel blocker.
SGTC_644 1498-1197 63.3 µM 0.263169663495201 0.400366909869382 no 1316 0.396209905942802 1898 6741615
SGTC_2087 5276107 200 µM 0.261822385415109 0.400874259009098 no 1317 0.396729189929508 1818 144405
SGTC_1004 4084-0029 199 µM 0.261436030167654 0.40101978102641 no 1318 0.396878137417796 1959 716894 YLR208W SEC13
SGTC_2446 5162541 200 µM 0.260561219978657 0.401349331983882 no 1319 0.397215449388729 1799 1549321
SGTC_1563 conessine 56.1 µM 0.259985213553956 0.401566358498239 no 1320 0.39743758969553 1985 441082 An anti-amoebic, histamine inhibitor.
SGTC_780 0109-0199 192 µM 0.259970792883932 0.401571792278487 no 1321 0.397443151539939 1978 610414
SGTC_357 1325-0123 420 µM 0.258103414312792 0.402275590254123 no 1322 0.39816354829827 1971 1098503
SGTC_1995 st072814 61.1 µM 0.257113395081236 0.402648848184604 no 1323 0.398545618647652 1814 5769371
SGTC_2892 9047358 58.44 µM 0.256497399806919 0.402881136085731 no 1324 0.398783393978045 1836 6466771
SGTC_2347 9049783 174.81 µM 0.255899161476232 0.403106760772719 no 1325 0.399014351058465 1923 6467988 YPL169C MEX67
SGTC_2159 5658611 73.75 µM 0.255510214214998 0.403253468959194 no 1326 0.399164527784837 1942 793844
SGTC_1279 0874-0590 65.2 µM 0.255113714301614 0.403403039970434 no 1327 0.399317636034254 1900 3523074
SGTC_2883 9059145 45.46 µM 0.253307228533356 0.404084676172853 no 1328 0.400015405332739 1823 16476510
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.252288870147561 0.404469059022265 no 1329 0.400408895147393 1872 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_668 1682-0499 62.6 µM 0.251076061897199 0.404926957933467 no 1330 0.400877651530807 1856 682214
SGTC_2857 9024691 58.44 µM 0.249335556038365 0.405584317816055 no 1331 0.401550614933277 1852 16478292
SGTC_998 3996-0085 177 µM 0.249044514844946 0.405694265240378 no 1332 0.401663174036075 1952 715391
SGTC_1515 3460-0031 42.1 µM 0.248974589305525 0.405720682310716 no 1333 0.401690218695205 1928 2876596
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.246418048362105 0.406686808166231 no 1334 0.40267931817005 1839 2333 A French combination drug.
SGTC_601 0986-0029 62.9 µM 0.246178147120808 0.406777496946261 no 1335 0.402772165583687 1862 24747981
SGTC_924 2046-0044 21.3 µM 0.244863290305526 0.407274634981258 no 1336 0.403281143302119 1822 3623589
SGTC_2514 salinomycin 42.74 µM 0.244711610569686 0.407331993640028 no 1337 0.403339868700532 2011 23682228 A polyether potassium ionophore.
SGTC_1562 morin hydrate 59.1 µM 0.243784028384886 0.407682807943455 no 1338 0.403699045352392 1866 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3029 9088683 49.47 µM 0.243070294209576 0.40795279472175 no 1339 0.403975471488087 1903 25236615
SGTC_3344 9148862 3.898 µM 0.242973157166718 0.407989542480542 no 1340 0.404013095952242 1958 4905352
SGTC_541 4513-1321 94 µM 0.242121527383684 0.408311755797442 no 1341 0.404342998973789 1823 747515
SGTC_1983 st071813 46.9 µM 0.239645028545416 0.40924908832458 no 1342 0.405302726994156 1883 11838595
SGTC_1623 st003709 20.3 µM 0.239145887173532 0.409438071871552 no 1343 0.405496230519358 1815 16192618
SGTC_148 3253-0744 288.01 µM 0.237154196305615 0.410192369570032 no 1344 0.406268584391813 1941 6893655
SGTC_2378 9074213 121.43 µM 0.23709157085459 0.410216092627964 no 1345 0.406292875724254 1879 657714
SGTC_1435 4092-0789 56.7 µM 0.237009187047011 0.410247300821218 no 1346 0.406324831531767 1976 2248285
SGTC_2528 xanthyletin 44.79 µM 0.236642897918956 0.410386063388377 no 1347 0.406466918761547 1851 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_877 0771-0151 33.1 µM 0.235091057945388 0.41097407650931 no 1348 0.40706902947754 1907 6166523
SGTC_2696 st077691 74.316 µM 0.23475295007488 0.411102216740265 no 1349 0.40720024383159 1902 757133
SGTC_2722 naftopidil 47.16 µM 0.23440189911319 0.41123527233869 no 1350 0.407336492216664 1964 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1199 1638-0010 4.46 µM 0.234283153104715 0.41128028185172 no 1351 0.407382581943777 1836 3111136
SGTC_2704 st078022 71.1 µM 0.23365539050086 0.411518248518574 no 1352 0.407626261170756 2006 54697681
SGTC_2143 5623677 140.463 µM 0.233573743468682 0.411549200943739 no 1353 0.407657956808291 1987 5375313
SGTC_583 1488-1091 88.9 µM 0.231010286442279 0.412521287609931 no 1354 0.408653405363769 2052 4303273
SGTC_1339 1486-1321 22.7 µM 0.227189878805546 0.413971016127186 no 1355 0.410138048743005 1887 3469382
SGTC_2246 7293507 91.5585 µM 0.226990832226128 0.414046580574689 no 1356 0.410215435472722 2042 887656
SGTC_1109 tnp00067 928.257 nM 0.226162928156551 0.414360913552198 no 1357 0.410537351326608 1884 676295
SGTC_233 rapamycin 362 pM 0.225494796608524 0.414614625196408 no 1358 0.410797186425282 2021 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3046 9092212 49.47 µM 0.22470802687511 0.414913433351613 no 1359 0.411103209876611 1923 25236637
SGTC_1039 k821-0043 94 µM 0.223833571663971 0.415245601434893 no 1360 0.41144340311945 1999 15992768
SGTC_2676 harmalol 100 µM 0.22312734679861 0.415513910251542 no 1361 0.411718197574546 1998 5459187 A monoamine oxidase inhibitor
SGTC_744 1594-0068 283 µM 0.222588725173699 0.415718569765655 no 1362 0.411927806164246 1879 668392
SGTC_3187 9109394 49.47 µM 0.222213321983864 0.415861224859712 no 1363 0.412073911958116 1861 17098090
SGTC_1808 st050063 61.5 µM 0.221845991249121 0.416000823113276 no 1364 0.412216887775114 2013 4011993
SGTC_19 0279-0214 38.434 µM 0.220885126244801 0.416366034787645 no 1365 0.412590939466394 1944 3566274 YBR002C RER2
SGTC_703 3875-0075 71.8 µM 0.219717147102729 0.416810064934412 no 1366 0.413045724758782 1935 2850814
SGTC_1925 st057770 10.1 µM 0.215448505237852 0.418433771555333 no 1367 0.414708828054912 1773 5989122
SGTC_2597 laccaic acid a 100 µM 0.215373195969289 0.418462430272371 no 1368 0.414738183080612 1904 5491415 A textile dye.
SGTC_1488 4013-0813 75.9 µM 0.213447345159796 0.419195453689216 no 1369 0.415489027574807 1906 2910057
SGTC_2120 5538279 151.968 µM 0.213408198187211 0.419210356851553 no 1370 0.41550429328044 1936 2058197
SGTC_1822 st052468 42 µM 0.213015289798028 0.419359942587213 no 1371 0.41565751841615 1926 2873678
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.211078690827737 0.420097402883172 no 1372 0.416412933939547 2030 140250 A respiratory chain inhibitor.
SGTC_237 nikkomycin 200 µM 0.210662722368745 0.420255841103892 no 1373 0.416575232510598 2029 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_595 3909-8003 73.7 µM 0.210367113603588 0.420368443378806 no 1374 0.41669057894104 1968 699517
SGTC_70 0141-0289 43.283 µM 0.210153869349008 0.420449675694369 no 1375 0.416773791224251 1948 352408
SGTC_2844 9010103 25.97 µM 0.209040468522614 0.420873864591393 no 1376 0.417208323554022 1912 2480525
SGTC_3291 9121177 71.43 µM 0.208924649685926 0.420917995103169 no 1377 0.417253530548902 1901 17015612
SGTC_1154 4088-0362 150 µM 0.205683765495474 0.422153271881309 no 1378 0.418518970338579 1996 6618304
SGTC_2517 totarol 10 µM 0.203891244148664 0.422836828880918 no 1379 0.419219243758613 1882 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1514 1189-1591 158 µM 0.20347407493334 0.42299594488138 no 1380 0.419382253518981 2028 767698 YMR146C TIF34
SGTC_2200 6600604 21.907 µM 0.202751458598924 0.423271593735101 no 1381 0.41966465012055 1959 2904777
SGTC_638 3970-0837 4.09 µM 0.202009924717812 0.423554497914772 no 1382 0.419954482665746 1902 4118451 YLR208W SEC13
SGTC_3289 9119912 71.43 µM 0.199376768943517 0.424559396291789 no 1383 0.420984015685807 1963 17014829
SGTC_227 fluconazole 33.516 µM 0.199181425731646 0.424633965276977 no 1384 0.421060414216048 1913 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1078 idebenone 36.1 µM 0.199159634980457 0.42464228369697 no 1385 0.421068936740883 1990 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1063 disulfiram 1.84 µM 0.199089304705309 0.424669131865292 no 1386 0.421096443686809 1984 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_872 0588-0139 234 µM 0.198927733583556 0.424730812012914 no 1387 0.421159637392234 1986 2047100
SGTC_1323 1348-1351 11.2 µM 0.198557401225626 0.424872194193885 no 1388 0.421304489463627 1911 6989654
SGTC_2124 5246320 200 µM 0.197496635074951 0.425277217450908 no 1389 0.421719457203296 1954 579342
SGTC_1368 1852-0141 284 µM 0.196982425869302 0.42547358196034 no 1390 0.421920645232115 1947 2838987
SGTC_1402 3909-7673 35.9 µM 0.196091849340724 0.425813716086533 no 1391 0.422269137850795 1996 5328014
SGTC_2617 dihydrotanshinone i 20.83 µM 0.195769959063887 0.425936667874456 no 1392 0.422395112127798 1931 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2303 7774051 200 µM 0.19510066626279 0.426192339350306 no 1393 0.422657070498924 2045 2953184
SGTC_1361 1608-0041 5.61 µM 0.193218460538634 0.42691151247893 no 1394 0.42339394086477 1963 X1361
SGTC_3288 9119690 36.221 µM 0.192840929487336 0.427055792885175 no 1395 0.423541773981796 1905 17595618 YKL019W RAM2
SGTC_2761 levamisole 97.89 µM 0.192474664271332 0.427195777172661 no 1396 0.423685205924085 2068 26879 An alkaline phosphatase inhibitor.
SGTC_543 3844-1095 191 µM 0.190803478468054 0.427834610080835 no 1397 0.424339781665762 2021 4230703
SGTC_1747 st037496 66.6 µM 0.19051269395591 0.427945785685348 no 1398 0.42445369850425 1973 723305
SGTC_2227 7312221 64.1025 µM 0.190373361822559 0.427999058549374 no 1399 0.424508285065641 2041 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_749 1000-0129 128 µM 0.190098474684806 0.428104163961112 no 1400 0.424615982656695 2073 708470
SGTC_1365 1672-3266 55.4 µM 0.188061957700946 0.428883001776954 no 1401 0.425414041156565 2069 6415873
SGTC_1065 prochlorperazine maleate 2.48 µM 0.187572000217895 0.429070420706264 no 1402 0.425606088604548 2023 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2133 5320837 200 µM 0.187539871967808 0.429082710989426 no 1403 0.425618682454053 2035 2841355
SGTC_2165 5727197 32.143 µM 0.187228103845691 0.429201977776622 no 1404 0.425740895377368 1982 1361712
SGTC_1013 4112-3890 241 µM 0.181724452576476 0.43130845209359 no 1405 0.4278994875519 1956 705171
SGTC_1451 4152-0210 104 µM 0.181396328270182 0.431434101149104 no 1406 0.428028250344417 2074 659563
SGTC_164 4100-3994 89.624 µM 0.181341717651341 0.431455013936258 no 1407 0.428049681429746 2111 4615967
SGTC_142 0335-0849 62.6745 µM 0.18122147968709 0.431501058972675 no 1408 0.428096867690844 2019 3889043 YPR107C YTH1
SGTC_1374 2889-5571 141 µM 0.181021218755322 0.431577750809138 no 1409 0.428175460496855 1962 2853281
SGTC_496 calpeptin 138 µM 0.177187067287518 0.433046569835996 no 1410 0.429680726873825 1966 73364 A calpain inhibitor.
SGTC_2330 7979373 200 µM 0.176896528783749 0.433157909746491 no 1411 0.429794832626664 1888 1863007
SGTC_1700 st030840 7.9285 µM 0.176453987572855 0.433327510193926 no 1412 0.429968647011765 2110 5499307
SGTC_747 3448-8087 38.7 µM 0.175993478538478 0.433504009705496 no 1413 0.430149532927062 1960 5168703
SGTC_99 0109-0120 622.8 µM 0.175387798148063 0.433736169296742 no 1414 0.430387463825821 2082 759414
SGTC_2732 terfenadine 20 µM 0.174634415879346 0.43402497547505 no 1415 0.430683452076547 2102 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2301 7769476 200 µM 0.173695235918057 0.434385055785211 no 1416 0.431052490899876 2015 977820
SGTC_2205 7238770 200 µM 0.173389026823512 0.434502467715774 no 1417 0.43117282490007 2104 279867
SGTC_829 1635-0120 117 µM 0.172155433526877 0.434975531580027 no 1418 0.431657666797121 2101 285054
SGTC_2083 5306046 65.942 µM 0.171777925185069 0.435120318799268 no 1419 0.431806060345845 1986 539837
SGTC_63 0099-0242 26.702 µM 0.171006806071697 0.435416096077971 no 1420 0.432109206978599 2128 3898502 YLR359W ADE13
SGTC_2387 9077560 195.08 µM 0.170747784640844 0.435515456748512 no 1421 0.432211043901823 1964 5303272
SGTC_2560 caryophyllene 100 µM 0.17005514383491 0.435781173876192 no 1422 0.432483384822182 2110 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1930 st074634 34.3 µM 0.169859436021509 0.435856258335321 no 1423 0.432560341414291 1983 684253 YOR116C RPO31
SGTC_1746 st038117 42 µM 0.16898957529679 0.436190013481363 no 1424 0.432902420589565 1975 2898218
SGTC_3122 9126309 49.47 µM 0.16865506996017 0.436318371284222 no 1425 0.433033980692984 2145 17591206
SGTC_3126 9127922 49.47 µM 0.167778107727147 0.436654914746791 no 1426 0.433378922922694 2033 45595682
SGTC_599 1935-0052 86.5 µM 0.167556433858241 0.43673999169093 no 1427 0.433466123639464 2058 9557311
SGTC_2286 7945697 125 µM 0.167377193079411 0.436808785239393 no 1428 0.433536634654113 1946 1245733
SGTC_94 0334-0113 514.748 µM 0.167101281405641 0.436914685317262 no 1429 0.433645178887882 1948 6795178
SGTC_160 3453-0671 289.699 µM 0.166835671085011 0.437016635813366 no 1430 0.433749675275499 2039 5322268
SGTC_2358 9037157 4 µM 0.166392640390563 0.437186695734903 no 1431 0.433923982670021 2029 2388925
SGTC_852 0418-0143 439 µM 0.164909187802351 0.437756212002352 no 1432 0.434507730297533 2119 5369229
SGTC_1081 sertraline 6 µM 0.164717028032481 0.437829994035486 no 1433 0.434583356812273 2129 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1074 carmofur 3.8 µM 0.164713243464976 0.437831447186984 no 1434 0.434584846292985 2112 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.164132472136378 0.438054454514988 no 1435 0.434813429688223 2041 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2344 7990960 76.95 µM 0.16354077953158 0.438281675678766 no 1436 0.435046333951986 1988 140813
SGTC_456 gingerol 170 µM 0.163459506585906 0.438312887619828 no 1437 0.435078326676172 2054 442793 A herb.
SGTC_1195 1502-0147 41.1 µM 0.161050245189968 0.439238310232425 no 1438 0.436026913585854 2030 817940
SGTC_762 1165-0429 115 µM 0.160523873070216 0.439440539685145 no 1439 0.43623420873748 2129 5967793
SGTC_1993 st073995 70.8 µM 0.160409284059471 0.439484566288581 no 1440 0.436279338349292 2042 3098394
SGTC_1463 k081-0032 34.1 µM 0.159943342629405 0.439663594811715 no 1441 0.43646285275543 2061 977755
SGTC_1573 oleylamine 1.06 µM 0.159462921105331 0.439848199937127 no 1442 0.436652084571958 2003 5356789 An amine of the fatty acid oleic acid.
SGTC_1963 st076565 50.3 µM 0.158677490703285 0.440150034879153 no 1443 0.436961486641476 2035 4914280
SGTC_832 4083-0019 164 µM 0.158088105105748 0.44037655414543 no 1444 0.437193686748819 2104 1990758
SGTC_3195 9113082 49.47 µM 0.157502309202823 0.440601713116866 no 1445 0.437424494064119 2173 17018038
SGTC_298 1391-0729 10 µM 0.156540612944534 0.440971396339365 no 1446 0.43780345465604 2009 3237558
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.155771847997847 0.441266952339791 no 1447 0.438106430875982 2107 66535 A nucleotide analog.
SGTC_715 0868-0130 184 µM 0.155475494407242 0.441380895886363 no 1448 0.438223235820647 2154 2876258
SGTC_1898 st060199 18.6 µM 0.154751055521043 0.441659452268174 no 1449 0.43850878914488 1989 688866
SGTC_480 am 92016 50 µM 0.153643764517607 0.44208527609504 no 1450 0.438945313761952 1989 2129 K+ channel blocker.
SGTC_1405 3909-7894 12 µM 0.152656514465291 0.442464992997041 no 1451 0.439334577575499 2127 7104060
SGTC_3191 9110352 49.47 µM 0.152548433065358 0.442506566567885 no 1452 0.439377196668916 2098 17122424
SGTC_920 mycophenolic acid 780.421 nM 0.152011245243512 0.4427132055482 no 1453 0.439589033152889 2008 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2687 chenodiol 100 µM 0.150861201700569 0.443155642856721 no 1454 0.440042603343148 2060 5702181 A cholesterol synthesis inhibitor.
SGTC_1900 st060200 72.8 µM 0.149488998102655 0.443683640845821 no 1455 0.440583895033309 2001 688945
SGTC_433 pimozide 108 µM 0.149321884264944 0.443747949938412 no 1456 0.44064982385599 1908 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2162 5663267 200 µM 0.149008713772474 0.443868468842838 no 1457 0.440773378567507 2129 6456493
SGTC_1686 st019653 115.5 µM 0.148751082557842 0.443967618192795 no 1458 0.440875025769495 2145 97252
SGTC_2400 5203494 178.7 µM 0.147713697232146 0.444366891273872 no 1459 0.441284360698716 2133 6777674
SGTC_2404 5161160 200 µM 0.147558824001803 0.444426504366189 no 1460 0.441345476481689 2038 2831543
SGTC_1609 st001574 46.4 µM 0.14710665488766 0.444600558412747 no 1461 0.441523918593778 2057 3960012
SGTC_273 hydroxyurea 18.1 mM 0.147059584423014 0.444618677922569 no 1462 0.441542494966164 2039 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1010 4112-3296 15.2 µM 0.146887068620404 0.444685087896644 no 1463 0.441610579476176 2168 704384
SGTC_2201 6605497 169.863 µM 0.14577209309376 0.445114335194662 no 1464 0.442050653512638 2124 670741
SGTC_1888 azatryptophan 97.5 µM 0.145489132379079 0.445223280690063 no 1465 0.442162347781502 2043 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.145172161820507 0.445345325563417 no 1466 0.442287472358702 2048 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_728 3030-5151 22.5 µM 0.144973685717325 0.445421748519398 no 1467 0.442365824013915 2065 3125388
SGTC_153 4077-0274 519.67 µM 0.14242596737689 0.446402923162751 no 1468 0.443371776230396 2160 3121976
SGTC_1645 Cervolide 78 µM 0.140574134061187 0.447116305638842 no 1469 0.444103191661426 2066 23173 A fragrance.
SGTC_2777 climbazole 1.536 µM 0.140461376958268 0.447159748652748 no 1470 0.444147733316479 2176 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1331 1472-0049 76.2 µM 0.139971683114529 0.447348425060487 no 1471 0.444341181851166 2025 24051409
SGTC_1588 farnesol 29.9 µM 0.139853321684314 0.447394030873533 no 1472 0.444387941312799 2015 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_12 0849-0099 9.267 µM 0.138721029519375 0.447830349151707 no 1473 0.444835299808715 2158 6071388
SGTC_645 0845-0943 5.41 µM 0.138390087449031 0.447957886553074 no 1474 0.444966065353718 2067 1885106
SGTC_1174 0739-0097 51.1 µM 0.138189794768321 0.448035077322839 no 1475 0.445045210155736 2058 728447
SGTC_912 3474-0017 2.18 µM 0.137835888448643 0.448171474041051 no 1476 0.445185060087802 2113 3360550
SGTC_374 0880-0231 82.3 µM 0.137128526043596 0.448444112302969 no 1477 0.445464602464667 2140 6833587
SGTC_1441 4106-0040 13 µM 0.136014704138814 0.448873461314816 no 1478 0.44590482838512 2161 2904180
SGTC_418 lividomycin a 100 µM 0.135776203343884 0.448965404891177 no 1479 0.445999101902894 2180 72394 An antibiotic.
SGTC_629 3448-6466 76.7 µM 0.135753508916506 0.448974153880438 no 1480 0.446008072612871 2128 573744
SGTC_1061 3448-9325 110 µM 0.134816461653937 0.449335419083761 no 1481 0.446378495073038 2191 723482
SGTC_3283 9109332 35.8195 µM 0.134204986602361 0.449571187232236 no 1482 0.446620241423916 2164 17027281
SGTC_118 0083-0097 135.343 µM 0.133216348621046 0.449952416774954 no 1483 0.447011140877482 2087 5207356
SGTC_2224 6650123 117.647 µM 0.132752606537072 0.450131256695748 no 1484 0.447194518505277 2090 2908370
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.132359086919603 0.450283023602375 no 1485 0.447350136904956 2047 6708561
SGTC_36 0335-0881 14.2 µM 0.131356707528745 0.450669639462531 no 1486 0.447746567117434 2100 23828853
SGTC_960 1222-0186 7.7 µM 0.131238062659673 0.450715403672456 no 1487 0.447793493343121 2103 3126296
SGTC_731 3966-0296 387 µM 0.131137858296118 0.45075405544157 no 1488 0.447833126579235 2139 660956
SGTC_179 1273-0063 6.77 µM 0.129817186617813 0.451263520838132 no 1489 0.448355532513119 2083 3108139
SGTC_88 0180-0332 8.668 µM 0.129511480516242 0.451381462213504 no 1490 0.448476470659905 2183 3101745
SGTC_1936 st074407 74.3 µM 0.129388081696743 0.451429070678929 no 1491 0.448525288918197 2039 809813
SGTC_349 k015-0014 24 µM 0.127066473087699 0.45232489933742 no 1492 0.449443893462564 2051 2196908
SGTC_758 0868-0029 16 µM 0.126793924740877 0.452430082350756 no 1493 0.449551752141723 2204 762687
SGTC_57 miconazole 162.5 nM 0.125040522833242 0.453106842157184 no 1494 0.450245734745938 2149 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_954 1189-0853 2.85 µM 0.124975924288897 0.453131777844356 no 1495 0.450271305258021 2209 2828194
SGTC_22 0964-0034 14.468 µM 0.12403130178756 0.45349643268039 no 1496 0.450645245585901 2089 138402
SGTC_1840 st055363 71 µM 0.123245820504729 0.453799683732214 no 1497 0.450956221301314 2020 676033
SGTC_1671 st016596 74.5 µM 0.122783173348676 0.453978310709476 no 1498 0.451139399575841 2170 2829167
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.121929090863426 0.454308094375389 no 1499 0.451477588166832 2096 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_315 k915-0449 187 µM 0.121487882897729 0.454478468706163 no 1500 0.451652305830875 2106 20970215 YNL149C PGA2
SGTC_3057 9095946 49.47 µM 0.121328830017517 0.454539889707229 no 1501 0.451715292820937 2204 24540043
SGTC_1022 4477-0945 21.3 µM 0.121149893816858 0.454608990293181 no 1502 0.451786155314971 2060 4648966
SGTC_2368 9071271 200 µM 0.120876838599388 0.454714439883968 no 1503 0.4518942938766 2077 27209959
SGTC_691 1548-0686 185 µM 0.12074985934411 0.454763478344411 no 1504 0.45194458292171 2077 46495133
SGTC_3302 9125395 16.351 µM 0.120569335450323 0.454833196539564 no 1505 0.452016079188871 2096 17599668
SGTC_2232 chlorophetanol 41.5365 µM 0.119826236842648 0.455120195303646 no 1506 0.452310398844787 2191 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2830 7992007 71.43 µM 0.119595376871607 0.455209362575718 no 1507 0.452401841080269 2052 1952075
SGTC_801 0866-0028 10.1 µM 0.119378886758851 0.455292981689257 no 1508 0.452487593795956 2111 6849771
SGTC_71 0417-1750 47.813 µM 0.11937814974981 0.455293266361728 no 1509 0.452487885732368 2209 6811472
SGTC_2194 5927483 104.545 µM 0.11843183768163 0.455658801789523 no 1510 0.452862750232501 2184 760979
SGTC_1005 4092-0690 4.4 µM 0.117732721517942 0.455928876078045 no 1511 0.453139719526567 2069 1529343
SGTC_2018 5133068 143 µM 0.117707901842974 0.455938464496414 no 1512 0.453149552772781 2153 785362
SGTC_3199 9111318 49.47 µM 0.117345105169773 0.456078624225184 no 1513 0.453293291573742 2151 8548020
SGTC_2871 9038510 12.99 µM 0.117258909654837 0.456111925059079 no 1514 0.453327442842281 2207 4945164
SGTC_1419 3993-2473 62.6 µM 0.117113216750996 0.456168212855501 no 1515 0.45338516817894 2117 704026
SGTC_2926 9010726 65.15 µM 0.117011691049227 0.456207437372706 no 1516 0.453425394504386 2065 2994293
SGTC_2616 abietic acid 100 µM 0.116211568426184 0.456516580144175 no 1517 0.453742434298383 2231 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1604 st002052 72.4 µM 0.115611072568918 0.456748610573716 no 1518 0.453980393557194 2113 6254834 YHR062C RPP1
SGTC_2316 5844804 197.44 µM 0.114160928275248 0.457309004159833 no 1519 0.454555112040768 2209 776813
SGTC_2513 baicalein 25.65 µM 0.111691632631788 0.458263433236672 no 1520 0.455533957004313 2094 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2074 5212007 75.395 µM 0.11133451005347 0.45840148786268 no 1521 0.455675545220458 2220 758611
SGTC_2105 5350118 200 µM 0.110824362725503 0.458598706716331 no 1522 0.45587781284568 2100 2133313
SGTC_2755 lomerizine 42.69 µM 0.109370391163612 0.459160856181187 no 1523 0.456454358634991 2137 3949 A calcium channel blocker.
SGTC_423 5-fluorouracil 457 µM 0.109015248824813 0.459298177424451 no 1524 0.456595197803309 2029 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1029 k015-0030 64.7 µM 0.108942921561088 0.459326144468278 no 1525 0.456623881370751 2120 2208316
SGTC_1225 1216-0074 20.6 µM 0.10879977484709 0.459381496117544 no 1526 0.456680651202704 2100 4241466
SGTC_1906 st060206 94.7 µM 0.107467538338867 0.459896679955089 no 1527 0.457209038400404 2205 5133468
SGTC_1985 st071382 65.5 µM 0.10478725616236 0.460933364272943 no 1528 0.45827231124158 2232 6123237
SGTC_575 k072-0246 11.9 µM 0.104709802108732 0.460963326071603 no 1529 0.458303041882841 2194 6796779
SGTC_3350 9150499 3.57 µM 0.103865733040142 0.4612898543321 no 1530 0.458637950528219 2222 4910996 YPR165W RHO1
SGTC_1197 1601-0112 267 µM 0.103679637795819 0.461361848827495 no 1531 0.458711793119971 2152 7350313
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.103334918345353 0.461495213466636 no 1532 0.458848581557791 2236 688801
SGTC_1265 0819-1001 68.8 µM 0.101880688404195 0.462057871654079 no 1533 0.459425689306376 2225 3106768
SGTC_109 0132-0036 33.701 µM 0.099421746638781 0.463009436510007 no 1534 0.460401708491718 2229 67274 A color developer.
SGTC_194 1486-1323 56.904 µM 0.0992212169148953 0.463087047203521 no 1535 0.460481314659244 2105 5178754
SGTC_520 3584-0023 682 µM 0.0989305069990381 0.463199562684505 no 1536 0.460596723316102 2057 1340790
SGTC_1286 0929-0070 131 µM 0.0974816035068562 0.463760385606485 no 1537 0.461171971460153 2180 1420408
SGTC_67 0335-0847 266 µM 0.0973041965994864 0.463829058961089 no 1538 0.461242411706637 2221 4552207 YOR254C SEC63
SGTC_199 4063-0024 41.6 µM 0.097177747683381 0.46387800738204 no 1539 0.461292619585516 2208 306215
SGTC_640 3381-0960 37.1 µM 0.0948600223336172 0.464775295805967 no 1540 0.462213005415833 2215 1745025
SGTC_396 dithiazanine 1.25 µM 0.0945025281131975 0.464913712833511 no 1541 0.462354987145488 2096 10578 An antihelmenthic.
SGTC_1163 k060-0048 49.9 µM 0.0935434641230681 0.465285070636268 no 1542 0.462735910835147 2233 6809982
SGTC_2493 resveratrol 26.09 µM 0.0929756166175106 0.465504960332056 no 1543 0.462961466208992 2230 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1155 4088-0394 48.2 µM 0.0914832303994076 0.466082912625736 no 1544 0.463554315279513 2106 2326248
SGTC_2945 9067681 61.76 µM 0.0909826959741406 0.466276769292089 no 1545 0.463753170317669 2246 16456930
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0904152146021458 0.466496564144274 no 1546 0.463978633354132 2214 23847180
SGTC_1153 4055-0057 267 µM 0.0898799806066889 0.466703878422897 no 1547 0.464191294957598 2107 882706
SGTC_1236 0330-0013 258 µM 0.0887161843093376 0.467154687299659 no 1548 0.464653735017225 2159 4617066
SGTC_1504 k297-0033 30 µM 0.088642339282988 0.467183293383877 no 1549 0.464683079311355 2198 4388117
SGTC_2569 tetrandrine 100 µM 0.0884528621787518 0.467256693794209 no 1550 0.464758373979321 2091 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1684 st024538 14.6195 µM 0.0875246465086775 0.46761628579191 no 1551 0.465127247760689 2164 6732859
SGTC_2431 5490079 200 µM 0.0868468305945331 0.467878889300177 no 1552 0.465396631393878 2187 5722345
SGTC_2505 galangin 7.89 µM 0.0867186820618911 0.467928538948297 no 1553 0.465447563110464 2107 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2204 7233102 200 µM 0.0846425992643852 0.468732961881764 no 1554 0.46627276562561 2206 2172480
SGTC_2412 st077135 33.4 µM 0.083821439936488 0.469051173142661 no 1555 0.466599200700976 2207 13258915
SGTC_152 4469-0003 551.229 µM 0.083331348106608 0.469241100335595 no 1556 0.46679403739312 2275 697280
SGTC_79 0052-0007 94.094 µM 0.0832896471649176 0.469257261187444 no 1557 0.466810616028784 2252 2801472
SGTC_1860 st056228 74.6 µM 0.0829588754864538 0.469385450782333 no 1558 0.466942119728384 2142 688679
SGTC_1436 4092-1007 8.32 µM 0.0828136775198752 0.46944172283193 no 1559 0.466999846699223 2253 2881121
SGTC_781 4335-2806 94.4 µM 0.0827860108883146 0.469452445214326 no 1560 0.467010846317937 2240 845254
SGTC_1207 2099-0101 141 µM 0.0815636049599073 0.469926218557261 no 1561 0.467496871930684 2261 5837381
SGTC_1919 st067113 52.3 µM 0.0812487844263475 0.470048241883894 no 1562 0.46762205168266 2187 1268243
SGTC_891 0929-0073 133 µM 0.0812374585406857 0.470052631809649 no 1563 0.467626555170251 2238 5603632
SGTC_1233 0325-0408 14.2 µM 0.0802041017530579 0.470453177287347 no 1564 0.468037463973377 2225 12874
SGTC_1705 st027868 56.3335 µM 0.0799360327594217 0.470557089980308 no 1565 0.468144065756871 2256 292948
SGTC_1758 st042942 75.2445 µM 0.0796589663344736 0.470664492491641 no 1566 0.468254247908686 2248 669317
SGTC_47 0149-0135 24.25 µM 0.0780663629295065 0.471281893195309 no 1567 0.468887632001388 2272 5239155
SGTC_2571 chrysanthemic acid 100 µM 0.077349089270202 0.471559979570578 no 1568 0.469172920128126 2121 2743 An insecticide.
SGTC_1133 3473-0247 50 µM 0.0771375432374005 0.471641998437879 no 1569 0.469257063388262 2063 711311
SGTC_2982 9019404 25.97 µM 0.0769582498122819 0.471711513534306 no 1570 0.46932837912299 2151 22333232
SGTC_1785 bathophenanthroline 24 µM 0.0765329873730302 0.471876398424249 no 1571 0.469497535398835 2111 72812 An iron chelator.
SGTC_363 0455-0021 3.06 µM 0.0760872244160243 0.472049237051834 no 1572 0.469674852057582 2241 4597466
SGTC_1519 esterone 74 µM 0.0758662289800146 0.47213492703155 no 1573 0.469762762384536 2142 698 A steroid.
SGTC_1439 4092-1168 46 µM 0.0754443779847833 0.472298501422511 no 1574 0.469930575635005 2249 2886240
SGTC_1564 D-Arginine 115 µM 0.0748423235488097 0.47253195849547 no 1575 0.470170083452358 2169 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_903 1134-0042 114 µM 0.0744096778429875 0.472699730220331 no 1576 0.470342204174022 2201 701009
SGTC_2850 9015429 58.44 µM 0.074236711020874 0.47276680480066 no 1577 0.470411017629069 2213 6457570
SGTC_3280 9140961 49.47 µM 0.0734309949015565 0.473079262559418 no 1578 0.470731576900061 2166 4901226
SGTC_2320 7373003 200 µM 0.0732056997890834 0.473166635268786 no 1579 0.470821215392285 2204 5415828
SGTC_504 lovastatin 124 µM 0.0726914378997326 0.473366078311609 no 1580 0.471025831045505 2123 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2182 6325192 200 µM 0.0726130994138179 0.473396460434644 no 1581 0.471057001207516 2282 736248
SGTC_804 1595-0054 20.9 µM 0.0718997195420783 0.473673138633551 no 1582 0.471340856623342 2140 761523 Stimulates phospholipase C.
SGTC_2043 5101342 149 µM 0.0702872626006158 0.474298562669578 no 1583 0.471982510202749 2215 678451
SGTC_1817 st052116 64.4 µM 0.0701017254023922 0.47437053111735 no 1584 0.472056346705262 2260 4361398
SGTC_3072 9116419 49.47 µM 0.0700954851454838 0.474372951679413 no 1585 0.472058830098615 2219 17170162
SGTC_1255 0566-0045 221 µM 0.0696839436523539 0.474532588493459 no 1586 0.472222610910757 2203 2788469
SGTC_2453 5731132 22.18 µM 0.069350343673596 0.474661994820858 no 1587 0.472355376853959 2257 1362040
SGTC_3316 9136639 10.545 µM 0.068637501351594 0.474938521486906 no 1588 0.47263908373999 2208 4903665
SGTC_1763 st044482 94.5 µM 0.066970794985009 0.475585119144461 no 1589 0.473302476605977 2258 88505
SGTC_3082 9117008 49.47 µM 0.0668902797705912 0.475616356611701 no 1590 0.47333452566373 2171 41448529
SGTC_1352 1496-0991 99 µM 0.0661856124636224 0.475889752581913 no 1591 0.473615025624044 2259 3000039
SGTC_2564 betulinic acid 100 µM 0.0661591619391995 0.475900015046254 no 1592 0.473625554778869 2294 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_562 3772-2733 112 µM 0.064943092177164 0.476371851675399 no 1593 0.474109655197298 2276 2876874 YIL048W NEO1
SGTC_1526 st051518 75 µM 0.0641989900657175 0.476660580630996 no 1594 0.474405890774327 2115 673993
SGTC_2321 7390090 138.78 µM 0.0632754190863596 0.477018964714805 no 1595 0.474773594629031 2201 649046
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0631674885061711 0.477060847502831 no 1596 0.474816566736195 2192 688803
SGTC_3216 9129716 49.47 µM 0.0623397149293437 0.477382075932446 no 1597 0.47514615101205 2258 8056934
SGTC_3299 9121982 43.1275 µM 0.0622099982596204 0.477432415530404 no 1598 0.475197800226973 2209 17594604 YPL160W CDC60
SGTC_2049 5262831 67.185 µM 0.0616598421598524 0.47764592050898 no 1599 0.475416860200222 2237 763417
SGTC_1433 4060-0023 7.6 µM 0.0608895601863227 0.477944862863304 no 1600 0.475723581891962 2265 3840627
SGTC_1273 0849-0096 14.1 µM 0.0606203618776018 0.47804934023612 no 1601 0.475830778456005 2234 5286025
SGTC_2765 myclobutanil 7.74 µM 0.0605602938011755 0.478072653199452 no 1602 0.475854698204124 2223 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2154 5570129 200 µM 0.0603752190688132 0.47814448284709 no 1603 0.475928397481397 2293 673366
SGTC_481 bay k-8644 50 µM 0.0593073557921554 0.478558946748921 no 1604 0.476353651177494 2208 2303 A calcium channel antagonist.
SGTC_1659 st012954 42.1 µM 0.0552122534402188 0.48014856735067 no 1605 0.477984683496816 2281 24207262
SGTC_2948 9070189 9.45 µM 0.0547466631187039 0.480329318819883 no 1606 0.478170146644299 2311 6473636 YDL196W YDL196W
SGTC_1773 st048542 73.5835 µM 0.0545957125267831 0.480387921726953 no 1607 0.478230277287023 2260 3237138
SGTC_2994 9053520 71.4286 µM 0.0541687749662301 0.480553672173149 no 1608 0.478400349056156 2282 4647384
SGTC_565 1418-0001 44.5 µM 0.0523424245657036 0.481262755831748 no 1609 0.47912792485658 2311 2862145
SGTC_1245 0418-0076 17.2 µM 0.0522498144648952 0.481298713459622 no 1610 0.479164820454268 2255 6790114
SGTC_2386 9075165 157.42 µM 0.0505027928675126 0.481977055906139 no 1611 0.479860861930109 2238 16452277
SGTC_2991 9074669 71.4286 µM 0.0493214110904098 0.482435798536292 no 1612 0.480331578349042 2303 17333109
SGTC_938 3126-1755 342 µM 0.0486769911727761 0.482686043224395 no 1613 0.480588356259155 2314 1777771
SGTC_3180 9109287 49.47 µM 0.0478673865197162 0.483000443013984 no 1614 0.480910965684898 2285 18891271
SGTC_1026 k007-1105 30.6 µM 0.0465909210417253 0.483496163732444 no 1615 0.481419634066508 2326 7066794
SGTC_3311 9131146 2.8755 µM 0.0461022378136074 0.483685952707324 no 1616 0.481614381194689 2214 4900406 YPR165W RHO1
SGTC_817 1391-0715 46 µM 0.0442552233670764 0.484403307218907 no 1617 0.482350481628117 2290 1353946
SGTC_508 roscovitine 141 µM 0.0425141151597106 0.485079575497745 no 1618 0.483044429826913 2332 160355 A CDKinase inhibitor.
SGTC_548 1436-0017 110 µM 0.0405212722700532 0.485853673245006 no 1619 0.483838774074265 2332 9677137
SGTC_3330 9141424 71.43 µM 0.0399688454460316 0.486068266887472 no 1620 0.484058982084592 2321 27261020
SGTC_589 1227-0070 34.1 µM 0.038818357072299 0.486515194144243 no 1621 0.484517604518667 2296 2841384
SGTC_62 0180-0423 3.232 µM 0.0383682421965061 0.48669005375181 no 1622 0.484697040692418 2288 30102 YGL099W LSG1
SGTC_2370 9071495 200 µM 0.0368463148104207 0.487281307412365 no 1623 0.485303772611454 2213 21791103
SGTC_260 nsc-65238 3.989 µM 0.036621967602058 0.487368466468161 no 1624 0.485393213831947 2329 3246252
SGTC_664 1222-0054 14.9 µM 0.0365369556109785 0.487401493847201 no 1625 0.485427106027088 2331 6813991
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0363829777731728 0.487461314856404 no 1626 0.485488493481144 2344 1273210
SGTC_352 k048-0007 5.11 µM 0.0362342153601478 0.487519109920064 no 1627 0.485547801990867 2324 6811911
SGTC_1302 1159-0335 255 µM 0.0361708990678866 0.487543708747873 no 1628 0.485573044989408 2320 649284
SGTC_1895 st058434 18.3 µM 0.0349966882477994 0.487999906454055 no 1629 0.486041190826307 2356 5393175
SGTC_2586 curcumin 80 µM 0.034655906954654 0.488132307829097 no 1630 0.486177060470691 2325 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2467 5474540 200 µM 0.0341070881051005 0.488345539325666 no 1631 0.486395878142283 2339 5413519
SGTC_3120 9124077 49.47 µM 0.0338738015847409 0.488436178686195 no 1632 0.486488892251028 2357 18774327 YGL155W CDC43
SGTC_787 4152-0075 138 µM 0.0337289091869353 0.488492474371324 no 1633 0.486546662942721 2240 9566539
SGTC_34 0469-0683 81.75 µM 0.0335720738919663 0.488553410541555 no 1634 0.486609195758164 2300 3690923
SGTC_2720 fluspirilene 36.88 µM 0.0329825220682086 0.488782475072704 no 1635 0.486844262713654 2338 3396 An atypical antipsychotic.
SGTC_402 epigallocatechin gallate 10 µM 0.0319248182348352 0.489193444661883 no 1636 0.487266003317604 2254 65064 An antioxidant.
SGTC_2768 sulfasalazine 50.2 µM 0.0315403455496582 0.489342833941013 no 1637 0.487419308521148 2349 5384001 An antioxidant and salicylic acid derivative.
SGTC_317 4495-0002 170 µM 0.030733245271364 0.489656442667285 no 1638 0.487741138892856 2258 15991618
SGTC_224 benfluorex 43.875 µM 0.0302881736885035 0.489829383445266 no 1639 0.487918614138219 2353 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2299 7976368 114.88 µM 0.0298132629552622 0.490013920883761 no 1640 0.488107990580251 2332 2979718
SGTC_585 0kpi-0023 191 µM 0.0284404765885349 0.490547360336761 no 1641 0.488655420798741 2353 64601
SGTC_209 4077-0173 175.592 µM 0.0280097597006889 0.490714732501838 no 1642 0.488827183543209 2299 15993494
SGTC_864 0469-0573 172 µM 0.0255996402125221 0.491651309553173 no 1643 0.489788336522952 2343 689425
SGTC_3104 9120930 49.47 µM 0.0251400249405908 0.491829922312583 no 1644 0.489971637487684 2276 17014836
SGTC_1512 0259-0544 12.2 µM 0.0249346666863302 0.491909727860923 no 1645 0.490053537903368 2307 18476
SGTC_2307 7538926 6.34 µM 0.0220165186311615 0.493043801001797 no 1646 0.491217389384733 2331 96582
SGTC_2808 7946468 45.46 µM 0.021659711856071 0.493182470036719 no 1647 0.491359700754071 2353 2970879
SGTC_2106 5357045 167.29 µM 0.0212083644626432 0.493357882422873 no 1648 0.491539720953921 2355 668842
SGTC_671 0560-0003 407 µM 0.0211196837305846 0.493392347599062 no 1649 0.491575091524977 2331 3238678
SGTC_1977 st070720 65.3 µM 0.0206488930541149 0.493575318081361 no 1650 0.491762868874966 2277 682188
SGTC_1201 1889-3372 45.9 µM 0.0197152546189824 0.493938176030887 no 1651 0.492135260859476 2321 5392199
SGTC_1693 xanthone 101.9 µM 0.0195258247302188 0.494011798451476 no 1652 0.492210817906331 2322 7020 An insecticide.
SGTC_823 0417-1665 178 µM 0.019469423694952 0.494033718900531 no 1653 0.492233314387447 2347 3429856
SGTC_1285 0929-0069 65.5 µM 0.0194183816639267 0.49405355657038 no 1654 0.492253673362823 2358 1206237
SGTC_637 1181-0519 7.26 µM 0.018977510066568 0.494224903517083 no 1655 0.492429523273107 2367 6252091 YGR060W ERG25
SGTC_1053 3366-3204 134 µM 0.0189727523808568 0.494226752621248 no 1656 0.492431420973425 2358 3632071 YPR165W RHO1
SGTC_2630 antimycin a 100 µM 0.0189129193719561 0.494250007103158 no 1657 0.492455286608186 2369 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2834 9001755 58.44 µM 0.0186893301934836 0.494336906640903 no 1658 0.492544470020961 2308 2989575
SGTC_1242 0402-0103 60.1 µM 0.0184969935338686 0.494411659878229 no 1659 0.492621187984371 2376 432868
SGTC_969 1313-0238 134 µM 0.0149777758266658 0.495779464988538 no 1660 0.494024955357918 2370 5212874
SGTC_3218 9131285 49.47 µM 0.0146381856155244 0.495911455505875 no 1661 0.49416041739788 2376 17156417
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0139666579299517 0.496172463410292 no 1662 0.49442829077969 2374 676296 Flavone; oxidizing agent.
SGTC_632 0781-2353 4.65 µM 0.0126353334362523 0.496689924423366 no 1663 0.494959365389939 2377 6811515 YHR007C ERG11
SGTC_2417 cerulenin 830 nM 0.0125871111519307 0.496708667636121 no 1664 0.494978601768245 2386 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_995 3931-2021 34.6 µM 0.011606434008753 0.497089842311244 no 1665 0.495369806704477 2363 730143
SGTC_3336 9143619 71.43 µM 0.0115861592130532 0.497097722853157 no 1666 0.495377894633881 2384 45595730
SGTC_857 0438-0306 1.35 µM 0.0110390946422314 0.497310359952327 no 1667 0.495596127853868 2332 4686136
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.0106524561652444 0.497460641916522 no 1668 0.495750365216805 2381 551469
SGTC_2350 9023895 38.85 µM 0.00972028449365878 0.497822967849039 no 1669 0.496122228602559 2376 2997209
SGTC_2031 5180455 200 µM 0.00807921174898942 0.498460840814554 no 1670 0.496776895905018 2392 29949
SGTC_2060 5238662 140 µM 0.00791499057757033 0.498524672625528 no 1671 0.496842408578641 2382 790130
SGTC_2782 7736369 71.43 µM 0.00752900828350637 0.498674701836547 no 1672 0.496996388643345 2392 2950836 YOL077C BRX1
SGTC_779 1360-0071 233 µM 0.00684426411132344 0.498940858606685 no 1673 0.497269554985248 2392 7566
SGTC_2000 st075254 36.4 µM 0.00684023251275066 0.498942425671194 no 1674 0.497271163322727 2393 17234175
SGTC_1673 st016611 27.3 µM 0.00588002326834697 0.499315655162028 no 1675 0.497654223625929 2390 5226799
SGTC_1182 1222-0449 220 µM 0.00551073346271198 0.499459196809013 no 1676 0.49780154655288 2390 658318
SGTC_2259 7964009 200 µM 0.00461104192468549 0.499808903997375 no 1677 0.498160466938144 2376 313134
SGTC_721 1187-1332 279 µM 0.00441033148077016 0.499886919526715 no 1678 0.498240538005627 2396 25730
SGTC_76 0433-0009 400.328 µM 0.0038284875632397 0.499886919526715 no 1679 0.498472658172156 2348 2841569
SGTC_1478 0453-0656 35.7 µM 0.0034840010847292 0.499753018701326 no 1680 0.498610087474192 2397 5258496
SGTC_296 1222-0039 74.9 µM 0.00322102051768297 0.499650798988768 no 1681 0.498715000951428 2402 5984176
SGTC_1839 st053978 48 µM 0.00318548282540909 0.499636985602074 no 1682 0.498729178366687 2400 3788398
SGTC_1837 st055472 66.5 µM 0.00316933779614847 0.499630710081267 no 1683 0.498735619268964 2385 676091
SGTC_2188 6126565 140.678 µM 0.00300400233024903 0.499566444724401 no 1684 0.498801578262472 2391 874518
SGTC_2661 dactinomycin 12.96 µM 0.00266321153184616 0.499433980488851 no 1685 0.498937533574253 2402 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2407 paclitaxel 400 µM 0.000125036969701977 0.498447403535812 no 1686 0.499950117466303 2402 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2692 st077426 47.7 µM 0 0.498398802428154 no 1687 0.5 2406 25238571
SGTC_2361 9034121 116 µM -0.000590076774810519 0.498169443516789 no 1688 0.499764593439506 2408 6496917
SGTC_2262 9014885 67.46 µM -0.0007794287148904 0.498095843803711 no 1689 0.499689052962555 2413 6457424
SGTC_1940 st075990 51.1 µM -0.0012769883122832 0.49790244634565 no 1690 0.49949055550911 2420 1084979
SGTC_651 3253-0966 34.4 µM -0.00153621123033536 0.497801688651623 no 1691 0.499387140629644 2408 781462
SGTC_1728 st035614 33.7865 µM -0.00216455263476989 0.497557458406382 no 1692 0.499136469110151 2429 15945546
SGTC_219 mitoxanthrone 164.414 µM -0.00345507584003607 0.497055847451863 no 1693 0.498621626907816 2404 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2880 9042983 58.44 µM -0.0039221126346593 0.496874316934065 no 1694 0.498435307453141 2416 6464714
SGTC_211 3455-0679 143.504 µM -0.00425038044995915 0.496746724317547 no 1695 0.498304348636252 2405 748649
SGTC_2736 butenafine 14.65 µM -0.00483823123120092 0.496518236662033 no 1696 0.4980698325299 2417 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1814 st052110 31.539 µM -0.00529308167044567 0.496341444769721 no 1697 0.497888375788174 2415 674163
SGTC_215 1287-0124 461.5 µM -0.0054399119895844 0.496284374711714 no 1698 0.497829799809357 2428 5560863
SGTC_1288 0973-0013 65.5 µM -0.00570609812702897 0.496180913588651 no 1699 0.497723608554065 2421 4315430
SGTC_713 1488-1073 324 µM -0.00581831307118145 0.496137298004921 no 1700 0.497678842011571 2415 3312542
SGTC_623 k072-0108 16.9 µM -0.00626906257750533 0.495962101642404 no 1701 0.497499022261243 2427 5382803
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.00754413816693316 0.495466512294442 no 1702 0.496990352864567 2428 5282362
SGTC_3068 9116768 49.47 µM -0.00774352350026469 0.495389016915838 no 1703 0.496910811948889 2428 41904888
SGTC_2783 7738165 71.43 µM -0.00867206020914194 0.495028123583134 no 1704 0.496540391887531 2421 17201110
SGTC_1316 1272-0050 65.9 µM -0.00895681327231216 0.494917449727518 no 1705 0.496426796264494 2430 7340392
SGTC_3044 9093193 49.47 µM -0.00900385349222273 0.494899166827266 no 1706 0.496408030688597 2431 25236277
SGTC_2277 7947813 106.88 µM -0.00905243376930852 0.494880285371507 no 1707 0.496388650751896 2430 1246798
SGTC_2524 avocatin b 10.57 µM -0.00927881553429774 0.494792298843728 no 1708 0.496298341287992 2419 6710748
SGTC_1613 st002381 52.1 µM -0.00938700112650878 0.494750251047071 no 1709 0.496255183360787 2423 551167
SGTC_1350 1495-0454 146 µM -0.00956140142580986 0.49468246813009 no 1710 0.496185610830271 2432 1069057
SGTC_2775 cyproheptadine 69.59 µM -0.0111228905735 0.494075582383285 no 1711 0.495562700166298 2423 2913 A selective serotonin reuptake inhibitor.
SGTC_2275 7947463 200 µM -0.0111317659461969 0.494072132933715 no 1712 0.495559159624072 2424 1225414
SGTC_3328 9140624 29.0385 µM -0.0112115516719406 0.494041123907963 no 1713 0.495527331710928 2426 4904392
SGTC_1887 st057648 70.8 µM -0.0121003032597375 0.493695709700528 no 1714 0.495172795222045 2427 688672
SGTC_223 busulfan 5 mM -0.0125935186803136 0.493504023049133 no 1715 0.494976045736854 2447 2478 A DNA alkylator.
SGTC_2356 9061756 188.97 µM -0.0126855285561766 0.493468263859457 no 1716 0.494939342039134 2419 20104043
SGTC_2006 4011487 200 µM -0.0127230061668887 0.493453698383797 no 1717 0.494924391842171 2432 45595294
SGTC_347 4534-1311 26.2 µM -0.0127302738174712 0.493450873850755 no 1718 0.494921492703867 2426 2862016
SGTC_803 4488-1585 147 µM -0.0131626014532604 0.493282852651951 no 1719 0.494749033385888 2420 747204
SGTC_1984 st072354 53.1 µM -0.0132007791158996 0.493268015219541 no 1720 0.494733804025256 2439 5762938
SGTC_3081 9117243 49.47 µM -0.0136194278619972 0.493105311466998 no 1721 0.494566802357724 2429 45595589
SGTC_1119 parthenolide 318.541 nM -0.0139696510004043 0.492969201539606 no 1722 0.494427096833819 2481 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3339 9145883 14.936 µM -0.0141623587619442 0.492894308379677 no 1723 0.4943502251651 2441 2030670
SGTC_3278 9139605 49.47 µM -0.01456755009299 0.492736837290479 no 1724 0.494188593889921 2488 7958859
SGTC_2587 piperic acid 92.2 µM -0.0148182102230267 0.492639422830473 no 1725 0.494088605759638 2438 5370536
SGTC_793 0488-0545 106 µM -0.0159027083754086 0.492217957656159 no 1726 0.493656004652598 2432 292548
SGTC_714 4296-0578 26.1 µM -0.016477679612078 0.49199451185067 no 1727 0.493426654380325 2454 1589775
SGTC_2852 9023854 51.95 µM -0.0167308454715473 0.49189612711387 no 1728 0.493325669737068 2459 19798528
SGTC_1172 0370-0043 85 µM -0.017078334095652 0.491761087684129 no 1729 0.493187061639749 2456 376585
SGTC_1121 fusaric acid 630.51 nM -0.0175979387424024 0.491559163084266 no 1730 0.492979800534221 2455 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1387 3342-1166 1.8 µM -0.0190286916507917 0.49100316667256 no 1731 0.492409108461594 2473 3418228
SGTC_419 nsc-638432 893 µM -0.0208838282360498 0.490282279219835 no 1732 0.491669163504965 2459 368090
SGTC_3228 9131799 49.47 µM -0.0211831464502926 0.490165970078947 no 1733 0.491549779225631 2456 17015818
SGTC_2229 7354935 190 µM -0.0211949533975424 0.490161382149734 no 1734 0.491545069992456 2440 318112
SGTC_2390 9097792 176.6 µM -0.0226892493147248 0.489580741170938 no 1735 0.490949075716822 2451 4497149
SGTC_162 k030-0015 37.8 µM -0.0230658820156179 0.489434395829519 no 1736 0.490798860324377 2466 1809920 YMR134W ERG29
SGTC_2874 9043904 71.43 µM -0.0233123338309395 0.489338634666301 no 1737 0.490700566706911 2496 4463428
SGTC_1696 st025591 34.7925 µM -0.0242375419684224 0.488979141900592 no 1738 0.490331566378882 2447 2787147
SGTC_2217 6934799 96.0675 µM -0.0252243877510633 0.48859570949349 no 1739 0.489937992265344 2446 675606
SGTC_2373 9071805 200 µM -0.0257195572017674 0.488403318624933 no 1740 0.489740512312513 2451 10149009
SGTC_2810 7959871 45.46 µM -0.0267848778020736 0.487989413048424 no 1741 0.489315657328729 2473 2974535
SGTC_1868 st057644 42.7 µM -0.0273519013067223 0.487769114481787 no 1742 0.489089530538238 2458 688665
SGTC_769 0302-0231 76 µM -0.0274686544381775 0.487723754305639 no 1743 0.489042970271951 2471 571869 YER009W NTF2
SGTC_3165 9101544 49.47 µM -0.0302603550173774 0.486639189372053 no 1744 0.487929707097629 2470 5002184
SGTC_2118 5526350 200 µM -0.0313970536299338 0.486197614188534 no 1745 0.48747644542857 2513 743594
SGTC_106 0092-0003 11.579 µM -0.0322138420240289 0.485880325472476 no 1746 0.487150758784848 2525 1072148
SGTC_622 1348-1566 26.3 µM -0.0328796166076002 0.485621706017404 no 1747 0.486885293798534 2500 7340407
SGTC_2873 9040596 71.43 µM -0.033401973010439 0.485418801436003 no 1748 0.48667701815363 2547 6463863
SGTC_1000 4048-0884 8.67 µM -0.0345393387281776 0.484977015224572 no 1749 0.486223536640548 2506 13040088
SGTC_2811 7967822 32.47 µM -0.0348570614128785 0.484853605684654 no 1750 0.48609685990885 2503 2232244
SGTC_1366 1683-0113 21.9 µM -0.0352375819296025 0.484705806181408 no 1751 0.485945147391063 2469 708623
SGTC_2906 7926292 26.41 µM -0.0354830673881845 0.484610457301579 no 1752 0.485847274069866 2509 2966319
SGTC_712 r015-0009 80.6 µM -0.0361170919391213 0.484364200238672 no 1753 0.485594496911209 2482 6813872 YLR060W FRS1
SGTC_3223 9129970 49.47 µM -0.0385659836961598 0.483413100078343 no 1754 0.484618211591775 2493 17248386
SGTC_2750 bromebric acid 70.15 µM -0.0398165457803167 0.482927443053 no 1755 0.484119692533124 2519 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1152 3909-8331 15.9 µM -0.0409323114648026 0.482494155703532 no 1756 0.483674929100592 2490 16001939
SGTC_1424 4048-1941 275 µM -0.0411830957745402 0.482396770996852 no 1757 0.48357496492851 2535 X1424
SGTC_2003 4023581 200 µM -0.0417723879623942 0.482167940861123 no 1758 0.483340073503554 2540 16641307
SGTC_3034 9090421 49.47 µM -0.0425809422224323 0.481853977868976 no 1759 0.483017793806528 2470 17173761
SGTC_2882 9058044 58.44 µM -0.0443001371705049 0.481186449197495 no 1760 0.482332581168601 2526 18076804
SGTC_883 0850-0245 24.6 µM -0.0458816087039271 0.480572442280193 no 1761 0.481702306433218 2641 6823229 YPR165W RHO1
SGTC_230 MPP+ 141.667 µM -0.0467847012651862 0.480221836834763 no 1762 0.481342411151656 2510 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_74 000s-0487 160.283 µM -0.0471040756016348 0.480097850555149 no 1763 0.481215139542438 2482 677548
SGTC_394 menadione 8.33 µM -0.0475885919514744 0.479909757156956 no 1764 0.481022062016714 2478 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2309 7664088 163.95 µM -0.0478808012941827 0.479796321146361 no 1765 0.48090562009355 2497 704922
SGTC_1051 3253-3903 78 µM -0.05012473464695 0.478925278786809 no 1766 0.480011494555784 2479 5509239
SGTC_818 4072-2707 53.5 µM -0.0509865675113656 0.47859076198203 no 1767 0.479668112099776 2501 882871
SGTC_2032 5185112 25.99 µM -0.0512128389089832 0.478502938179805 no 1768 0.479577960650297 2522 5718189
SGTC_1132 3456-3614 2.5 µM -0.051947592424827 0.478217761995441 no 1769 0.479285226085738 2557 3125502
SGTC_674 0498-0004 451 µM -0.0547098553204146 0.477145759769347 no 1770 0.478184808856834 2515 4231473
SGTC_2863 9028737 58.44 µM -0.0549251147487941 0.477062226924416 no 1771 0.478099061699842 2578 6460917
SGTC_3162 9099653 49.47 µM -0.0550061766236337 0.477030770588766 no 1772 0.478066771505436 2499 25237511
SGTC_136 0097-0015 404.482 µM -0.0558576654206752 0.476700356156091 no 1773 0.477727598122396 2479 4861337
SGTC_3266 9136860 49.47 µM -0.0559903645763726 0.476648864588786 no 1774 0.477674741537676 2501 4871271 YPR165W RHO1
SGTC_1768 st044301 37.178 µM -0.0580481253557708 0.475850437237967 no 1775 0.47685514731772 2540 3931349
SGTC_161 4065-0411 162.148 µM -0.0581682829459105 0.475803818113874 no 1776 0.476807292235828 2568 1906281 YLR208W SEC13
SGTC_3093 9117344 49.47 µM -0.0591718504221304 0.47541446380839 no 1777 0.476407615226811 2648 24824913
SGTC_1430 4049-0248 69.1 µM -0.0596392572343248 0.475233131870106 no 1778 0.476221475624088 2536 22774488
SGTC_1364 1653-0028 37.6 µM -0.0603800628408559 0.474945744535602 no 1779 0.475926468614941 2577 5718652
SGTC_2298 7976326 193.81 µM -0.0612068020323552 0.474625035616005 no 1780 0.475597256326597 2563 2235818
SGTC_2285 7945142 200 µM -0.0616213731362999 0.474464221243526 no 1781 0.475432177992073 2580 2970608
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.062587254417157 0.474089566856693 no 1782 0.475047589510278 2499 4174840
SGTC_2742 clothiapine 36.27 µM -0.0631313234108842 0.4738785387367 no 1783 0.474830965782537 2512 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2380 9035439 200 µM -0.0640902729682115 0.473506608713146 no 1784 0.474449173485359 2655 6462575
SGTC_440 fluspirilene 35.1 µM -0.0645054722726767 0.473345580185533 no 1785 0.474283874972511 2771 3396 An atypical antipsychotic.
SGTC_1507 4075-3230 155 µM -0.0650909605315716 0.473118515169562 no 1786 0.474050788810824 2496 659771
SGTC_944 3370-0224 231 µM -0.0652814264542324 0.473044650242633 no 1787 0.473974965169087 2541 4580514
SGTC_2628 lathosterol 100 µM -0.0655310857483581 0.472947830833553 no 1788 0.473875578336106 2598 6710616
SGTC_974 1326-0144 138 µM -0.0656412525496411 0.47290510797863 no 1789 0.473831722566503 2540 5411856
SGTC_1724 st037281 8.293 µM -0.0669184366316485 0.472409836906757 no 1790 0.473323317813713 2529 574124 YDL195W SEC31
SGTC_495 decylubiquinone 155 µM -0.0679810103916052 0.471997820676677 no 1791 0.472900375410614 2584 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1949 st076024 69.1 µM -0.0680084705297353 0.4719871733193 no 1792 0.472889445695306 2501 2921930
SGTC_475 α-linolenic acid 10 µM -0.0693205835086398 0.471478439850614 no 1793 0.472367220938124 2682 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1681 tripelennamine 100 µM -0.0701503511633325 0.471156745654377 no 1794 0.472036995473256 2513 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1782 st039423 80.636 µM -0.0704591535396356 0.471037030269146 no 1795 0.471914105233516 2570 2068169
SGTC_1215 3852-0577 11.2 µM -0.0710670881546462 0.470801356040804 no 1796 0.471672180882805 2651 2884876
SGTC_1547 harmine 94.2 µM -0.0712821202409045 0.470717998334248 no 1797 0.471586612504023 2523 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2754 granisetron 64.02 µM -0.071770371568972 0.470528731299682 no 1798 0.471392326029084 2582 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_618 k072-0232 33.2 µM -0.0719550994526792 0.470457124628422 no 1799 0.471318820312315 2580 5872756 YGL099W LSG1
SGTC_2642 cholecalciferol 100 µM -0.0721132652689187 0.47039581505691 no 1800 0.471255884776805 2536 9821465 A vitamin D precursor, similar to steriods.
SGTC_1916 st067606 49.2 µM -0.0724654870147405 0.470259286408113 no 1801 0.471115735303198 2608 19590279
SGTC_2921 7974240 10.71 µM -0.073625932750101 0.469809497750884 no 1802 0.470654017892846 2603 2979074 YDR527W RBA50
SGTC_3053 9095903 49.47 µM -0.0737627512438305 0.469756469443127 no 1803 0.470599583225291 2547 17174018
SGTC_2021 4019055 173 µM -0.0738945633799139 0.469705382013945 no 1804 0.470547140909005 2617 44827708 YER133W GLC7
SGTC_177 1327-0068 8.361 µM -0.0746120459133496 0.469427310634398 no 1805 0.470261694793918 2534 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1417 3966-0327 90.4 µM -0.0746762660098357 0.469402421874354 no 1806 0.470236145957284 2555 651118
SGTC_1052 3253-3998 198 µM -0.0754040203070699 0.469120386108828 no 1807 0.469946630288041 2531 5450317
SGTC_2052 5265182 7.135 µM -0.0768153638699234 0.468573474694003 no 1808 0.469385214125741 2594 1239884
SGTC_297 0986-0032 24 µM -0.0794367849034384 0.467557802870056 no 1809 0.468342605475193 2533 2847425
SGTC_3064 1327-0027 10 µM -0.0801901037533586 0.467265967608292 no 1810 0.468043030437917 2552 16000455 YPR107C YTH1
SGTC_2695 st077686 51.995 µM -0.0812316182871715 0.466862514526668 no 1811 0.467628877419332 2585 2876092
SGTC_2644 guaiazulene 100 µM -0.082114489414639 0.466520542029358 no 1812 0.467277835574602 2608 3515 A coloring agent.
SGTC_29 0299-0004 12.984 µM -0.0824928347788213 0.466374000774283 no 1813 0.467127407967156 2552 16871 A napthoquinone isolated from Swertia calycina.
SGTC_27 0485-0001 32.618 µM -0.0828856949401867 0.466221842452139 no 1814 0.466971214341424 2544 2054479
SGTC_2308 7584454 197.62 µM -0.0831107411878156 0.46613468221144 no 1815 0.466881742581967 2588 893577
SGTC_2335 9018011 154.17 µM -0.0841411244453671 0.465735636365165 no 1816 0.466472113987798 2655 6458208
SGTC_766 1391-0721 126 µM -0.0841671277474656 0.465725566275077 no 1817 0.466461776839456 2623 1020919 YIL115C NUP159
SGTC_2176 5809774 33.9695 µM -0.0844729731294573 0.46560712563766 no 1818 0.466340195169933 2611 2870539
SGTC_2048 5246248 200 µM -0.0858413026267488 0.465077268484562 no 1819 0.465796286443734 2584 677046
SGTC_1508 1080-0625 72.9 µM -0.0861218196661067 0.464968651709134 no 1820 0.46568478923926 2529 767111
SGTC_732 3970-1727 52.7 µM -0.0871705566069572 0.464562601790419 no 1821 0.46526797133502 2618 1275699
SGTC_1189 1431-2119 7.28 µM -0.0879974257051021 0.464242480649109 no 1822 0.464939361098159 2547 3107275
SGTC_719 2810-4230 27.3 µM -0.0892658796298224 0.463751445658594 no 1823 0.464435304947912 2568 721079
SGTC_3190 9110366 49.47 µM -0.0895458179049789 0.463643085327231 no 1824 0.464324071192273 2574 17123768
SGTC_1270 0831-1170 17.3 µM -0.0897361410522508 0.463569415343155 no 1825 0.464248447689713 2564 6764716
SGTC_587 k089-0003 57 µM -0.0903250776439876 0.463341458619618 no 1826 0.46401444626101 2558 9659696
SGTC_773 4358-1457 44.6 µM -0.090343682134517 0.463334257668796 no 1827 0.464007054364791 2555 1186886
SGTC_50 0929-0078 56.389 µM -0.0906184378384266 0.463227913651387 no 1828 0.4638978904666 2652 1377751
SGTC_2036 5160441 105 µM -0.0916019535948682 0.462847266105863 no 1829 0.463507149617027 2594 134534 YIL048W NEO1
SGTC_1546 5-methoxyflavanone 78.7 µM -0.0918251747436897 0.462760878129135 no 1830 0.463418471003096 2612 147795
SGTC_1426 4048-4480 71.7 µM -0.091856997139212 0.462748562806549 no 1831 0.463405829132375 2589 14224343
SGTC_604 1000-0114 314 µM -0.0919014609530305 0.462731355292831 no 1832 0.463388165351655 2608 1572745
SGTC_1749 st037932 54.2 µM -0.0920952768783333 0.462656349267261 no 1833 0.463311170505598 2673 594497
SGTC_542 3381-0244 89.3 µM -0.0934292716772282 0.462140134517015 no 1834 0.462781268390439 2672 1112843
SGTC_889 0919-1524 82.7 µM -0.0938810658125458 0.46196531856434 no 1835 0.46260181734627 2625 3905452
SGTC_114 0364-0001 490.298 µM -0.0942517380190638 0.461821897188313 no 1836 0.462454593329733 2613 4003655
SGTC_3263 9137018 49.47 µM -0.097412689065253 0.460599058017199 no 1837 0.461199334118556 2580 43844957
SGTC_3214 9129694 49.47 µM -0.0977475344904148 0.460469542008105 no 1838 0.461066384595409 2626 17158655
SGTC_2888 9058547 12.99 µM -0.0986500851835222 0.460120462258144 no 1839 0.460708050854852 2605 16476514
SGTC_3188 9110789 49.47 µM -0.0989303491644578 0.460012070731875 no 1840 0.460596785975606 2662 849217
SGTC_854 0422-0053 192 µM -0.0990517712650083 0.459965111902879 no 1841 0.460548582324821 2590 3596728
SGTC_2567 aureobasidin a 60 nM -0.0992754822308018 0.459878595302261 no 1842 0.460459772290771 2820 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2459 5811157 9.22 µM -0.0994179439045315 0.459823501542081 no 1843 0.460403218084089 2563 2870684 YBR192W RIM2
SGTC_1501 4491-0275 38.4 µM -0.102002935020595 0.458823951001482 no 1844 0.459377172714016 2584 5104718
SGTC_656 4090-1979 187 µM -0.102794152677083 0.45851805892216 no 1845 0.459063173084432 2606 22330961
SGTC_421 streptovitacin 30 mM -0.103380628671119 0.458291337708378 no 1846 0.458830442921387 2780 91467 include heat shock
SGTC_111 0083-0039 52.457 µM -0.104057592394779 0.458029652419041 no 1847 0.458561822231839 2572 759313
SGTC_2332 7982454 138.89 µM -0.105301466234831 0.457548871372059 no 1848 0.458068299779231 2568 2981748
SGTC_1333 1482-0047 286 µM -0.105578505985672 0.457441798639065 no 1849 0.4579583895792 2574 3811116
SGTC_528 3492-0019 172 µM -0.106511221387367 0.457081337427605 no 1850 0.457588376337634 2576 2869262
SGTC_2977 9011197 71.43 µM -0.106914489812538 0.456925499490639 no 1851 0.457428408936595 2815 2704722
SGTC_1467 k284-1082 293 µM -0.107164610036203 0.456828847048637 no 1852 0.45732919540338 2627 3334705
SGTC_1606 st000094 49.2 µM -0.109284302774609 0.456009850128754 no 1853 0.456488498295719 2591 1242210
SGTC_1636 st007707 68.9 µM -0.111352565603888 0.455210904550627 no 1854 0.455668386609836 2667 403051
SGTC_2151 5563267 85.4165 µM -0.111576349308786 0.455124470341612 no 1855 0.45557966271128 2647 5310824
SGTC_898 1000-0849 28.3 µM -0.111881058681215 0.455006782822467 no 1856 0.455458857641092 2572 6751807
SGTC_1675 st018485 24.5 µM -0.113035617291612 0.454560895011086 no 1857 0.455001158822039 2681 3323024
SGTC_3185 9108267 49.47 µM -0.113800788632736 0.454265419153693 no 1858 0.454697856708724 2655 4910486
SGTC_2066 5222451 176 µM -0.115114944885968 0.453758008373232 no 1859 0.454177007173389 2605 2281147
SGTC_1394 3474-0001 65.7 µM -0.115708561953259 0.453528830720633 no 1860 0.453941760189029 2672 5017666 YIL048W NEO1
SGTC_2973 9094665 17.96 µM -0.116215609255661 0.453333087295537 no 1861 0.453740833089886 2856 25237061 YIL048W NEO1
SGTC_1292 0kpi-0043 232 µM -0.11754541548612 0.452819775312773 no 1862 0.453213928553766 2662 3333905
SGTC_220 paclitaxel 373.376 µM -0.117545878386064 0.452819596644711 no 1863 0.453213745154803 2730 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_191 3914-0123 66.505 µM -0.117920342441811 0.452675065806416 no 1864 0.453065387382441 2617 3144412
SGTC_1938 st074717 56.4 µM -0.117940845913031 0.452667152320181 no 1865 0.453057264363678 2582 17250979
SGTC_1967 st070177 51.4 µM -0.11836463050235 0.452503593327561 no 1866 0.452889374749209 2731 5729214
SGTC_3008 9078912 71.4286 µM -0.11863118181757 0.452400722395574 no 1867 0.452783780135388 2642 16648731
SGTC_594 1487-1584 10.8 µM -0.118966858444435 0.452271178275384 no 1868 0.452650806199923 2652 5013332
SGTC_2349 9023730 187.07 µM -0.119580143371449 0.452034512859561 no 1869 0.452407875066211 2702 4126287
SGTC_2876 9059903 25.97 µM -0.120691345200824 0.451605745789245 no 1870 0.451967757205936 2612 6916095
SGTC_946 3434-1334 87.4 µM -0.120916241550433 0.45151897439254 no 1871 0.451878688832634 2731 4047976
SGTC_1944 st076371 56.9 µM -0.122815763987137 0.450786177514973 no 1872 0.451126495455129 2620 24208455
SGTC_1312 1218-2183 165 µM -0.124777186580373 0.450029676850331 no 1873 0.450349974346044 2610 6744073
SGTC_3127 9126946 49.47 µM -0.127456458047727 0.448996603100102 no 1874 0.449289566745485 2736 27243249
SGTC_2715 st079500 56.4 µM -0.129481955064081 0.448215840827047 no 1875 0.448488151261041 2620 28246688
SGTC_934 2950-0684 338 µM -0.131065552113196 0.447605555947866 no 1876 0.447861725737358 2859 1121253
SGTC_2985 9022375 71.43 µM -0.131860554251878 0.447299225569292 no 1877 0.447547294636 2842 4939335
SGTC_292 k038-0015 474 µM -0.131932508503688 0.447271501691615 no 1878 0.447518837651121 2746 46368540
SGTC_350 k064-0020 19.8 µM -0.132722990024036 0.446966947203353 no 1879 0.447206230153063 2764 2790705
SGTC_1701 st028638 40.4 µM -0.133881420932948 0.446520686757794 no 1880 0.446748170979094 2649 3490878
SGTC_1625 st003711 30.1 µM -0.134519507551848 0.446274906580323 no 1881 0.446495893242926 2784 24207034 YER133W GLC7
SGTC_2267 7931562 200 µM -0.135140944259269 0.446035559504999 no 1882 0.446250219127556 2600 934880
SGTC_2294 7971431 200 µM -0.13531132037257 0.445969942376224 no 1883 0.446182867515599 2757 5741572
SGTC_812 4251-0442 148 µM -0.136719875483841 0.445427520939113 no 1884 0.445626109346757 2616 5723007
SGTC_3249 9135183 49.47 µM -0.138655552923965 0.444682276440836 no 1885 0.444861171180021 2815 4902779
SGTC_1254 0550-0035 264 µM -0.139207982477921 0.444469624328105 no 1886 0.444642900409778 2784 15121435
SGTC_826 1683-5028 118 µM -0.140777574511698 0.443865513332841 no 1887 0.444022829779956 2731 722377
SGTC_2614 arthonioic acid 13.39 µM -0.14121855046676 0.443695812112222 no 1888 0.44384864588959 2637 6710684
SGTC_3131 9127911 49.47 µM -0.141255105253928 0.443681745159661 no 1889 0.443834207368662 2883 45595681
SGTC_2466 5983409 37.09 µM -0.142173064062238 0.443328521085748 no 1890 0.443471653701751 2703 2879657
SGTC_1376 2910-0861 41.3 µM -0.142911331055527 0.443044473809856 no 1891 0.443180104772748 2668 1112859
SGTC_1294 1000-1494 117 µM -0.143849933845709 0.442683389871345 no 1892 0.442809485689999 2676 712797 YDL207W GLE1
SGTC_1338 1486-1223 76 µM -0.144558763185511 0.442410732155959 no 1893 0.442529628680801 2733 3444526
SGTC_546 peri-Naphthalide 147 µM -0.144671719165753 0.442367285117142 no 1894 0.442485034522542 2765 223824 A penicillin ester.
SGTC_2970 9090938 41.86 µM -0.146732370668257 0.441574804687004 no 1895 0.441671633520157 2820 17217104
SGTC_557 1315-0110 16.2 µM -0.147117450995177 0.441426737251242 no 1896 0.44151965792498 2681 6833801
SGTC_1751 st044839 27.194 µM -0.147247175417874 0.441376858688606 no 1897 0.441468462891526 2635 5291326
SGTC_1909 st060837 51.5 µM -0.148365474583806 0.440946915415241 no 1898 0.441027172885581 2717 678937
SGTC_97 0535-0701 19.132 µM -0.149267121912879 0.440600317141393 no 1899 0.44067142875282 2696 2832013 YGL099W LSG1
SGTC_822 1487-0950 154 µM -0.150348616105586 0.440184644771015 no 1900 0.44024478938008 2683 1958375
SGTC_899 1083-0020 478 µM -0.150765086406627 0.440024591935127 no 1901 0.440080514203113 2855 767123
SGTC_20 0481-0013 4.944 µM -0.15356278456605 0.438949669689396 no 1902 0.438977241210503 2676 182045
SGTC_2937 9044753 11.33 µM -0.157277345741303 0.437523170183476 no 1903 0.437513136764012 2678 6465530 YGL099W LSG1
SGTC_2671 danthron 100 µM -0.157712930700781 0.437355945708791 no 1904 0.437341505396968 2720 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2013 4024628 200 µM -0.15802460214043 0.437236299470148 no 1905 0.437218706289928 2831 5230760
SGTC_2884 9058502 51.95 µM -0.159996041140749 0.436479625459411 no 1906 0.436442096378468 2783 6471554
SGTC_1657 st012939 43.4 µM -0.16113845912464 0.436041250903937 no 1907 0.435992175011883 2829 24207257
SGTC_700 3453-2283 142 µM -0.161982004080231 0.435717611846874 no 1908 0.435660012686681 2855 565664
SGTC_1184 1269-1718 139 µM -0.163174948803266 0.435259993700552 no 1909 0.435190344896599 2836 5403821
SGTC_1401 3807-4679 7.6 µM -0.163530218676126 0.4351237275476 no 1910 0.435050491160509 2685 3291456
SGTC_2093 5331342 194.4 µM -0.163586875476458 0.435101997162064 no 1911 0.435028188682608 2810 33839
SGTC_807 1315-0151 48 µM -0.164271891117683 0.434839278935698 no 1912 0.434758554355144 2779 4011080
SGTC_391 gliotoxin 8.33 µM -0.16430486715392 0.43482663264163 no 1913 0.434745575165814 2825 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2002 4023503 131 µM -0.165165759687673 0.434496504397691 no 1914 0.434406757448397 2719 4736863 YCR052W RSC6
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.165214294308188 0.434477894083991 no 1915 0.434387657321812 2697 16623 A steroid.
SGTC_2984 9022109 38.96 µM -0.166037191742846 0.434162381053767 no 1916 0.434063840799852 2706 6459207
SGTC_2877 9040724 71.43 µM -0.166053517256321 0.434156121994687 no 1917 0.434057417030544 2886 6463895
SGTC_2438 5259590 200 µM -0.16826814386773 0.4333072071633 no 1918 0.433186167004426 2828 1201127
SGTC_2518 prenyletin 46.28 µM -0.16830885631066 0.433291604060861 no 1919 0.433170153462639 2762 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2670 beta-carotene 100 µM -0.168788050800136 0.433107959902945 no 1920 0.432981678775109 2733 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2265 7929201 200 µM -0.17023424486166 0.432553815280879 no 1921 0.432412960626071 2681 1265108
SGTC_1278 0874-0585 172 µM -0.171272137212315 0.432156203128623 no 1922 0.432004894005406 2758 766306
SGTC_2140 5586273 200 µM -0.17146142886195 0.432083693697695 no 1923 0.431930478291823 2694 854421
SGTC_630 4356-0227 183 µM -0.17237891083333 0.431732278559124 no 1924 0.431569825359213 2720 779312
SGTC_1794 st048918 76.9 µM -0.173152780315277 0.431435912047681 no 1925 0.431265669381234 2678 672303
SGTC_1120 ficusin 1.78878 µM -0.173178849406479 0.431425929115786 no 1926 0.431255424085632 2850 6199 A DNA cross-linker.
SGTC_3225 9130819 49.47 µM -0.175265310480421 0.430627079559149 no 1927 0.430435584029242 2748 4547121
SGTC_51 1013-0126 23.419 µM -0.175917589659266 0.430377397565927 no 1928 0.430179343151789 2871 1627850
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.176398291255988 0.430193410523902 no 1929 0.429990523498515 2743 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2433 5607874 27.82 µM -0.176441780067134 0.430176766063594 no 1930 0.429973441876626 2719 2252428
SGTC_800 3448-7362 155 µM -0.177007245240253 0.429960357044199 no 1931 0.429751349282656 2784 15991913
SGTC_319 1348-1596 45.5 µM -0.177150310800755 0.429905607795758 no 1932 0.42969516224917 2910 5380505
SGTC_2134 5324836 1.464 µM -0.177230812027684 0.429874801661217 no 1933 0.42966354712419 2770 699272
SGTC_3080 9117754 49.47 µM -0.177361236187446 0.429824891971487 no 1934 0.429612326798848 2917 9550191
SGTC_1527 coumarin 137 µM -0.177405841698908 0.429807822943159 no 1935 0.429594809543176 2953 323 A hepatotoxic, DNA x-linker.
SGTC_1128 3448-9350 235 µM -0.178022340601313 0.429571923008989 no 1936 0.429352715358189 2829 619386
SGTC_1990 st072050 59.8 µM -0.178410763029962 0.429423308197133 no 1937 0.42920019861643 2680 17233948
SGTC_2764 methyldopa 94.69 µM -0.178954255484676 0.429215378633827 no 1938 0.42898681030613 2862 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_767 0929-0023 86 µM -0.180546457238583 0.428606346692658 no 1939 0.428361792988545 2743 1204563
SGTC_1852 st056254 31.4 µM -0.180779635352208 0.428517168135806 no 1940 0.428270274181361 2756 442583
SGTC_1179 1021-1431 9.29 µM -0.181883601753987 0.42809500776017 no 1941 0.427837036873517 2805 2840958
SGTC_1688 st021091 57.6 µM -0.183881008538901 0.427331402291407 no 1942 0.427053401875624 2723 3656366
SGTC_1122 capsaicin 818.572 nM -0.18446524615193 0.42710810049216 no 1943 0.426824244418186 2867 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3137 9097352 49.47 µM -0.184682625407563 0.427025021797522 no 1944 0.426738987331084 3039 44120435
SGTC_2329 6138490 200 µM -0.18475993236291 0.426995477159725 no 1945 0.426708668032665 3005 720019
SGTC_2377 9073351 62.6 µM -0.18535428452358 0.426768345449066 no 1946 0.426475581354739 2718 7337946 YHR072W ERG7
SGTC_2254 7938975 95.19 µM -0.18572117829888 0.426628149088225 no 1947 0.426331709687563 2928 2969277
SGTC_1846 st056244 14.8 µM -0.186591442401538 0.426295643452766 no 1948 0.425990488441528 2811 5393182
SGTC_784 4579-0127 173 µM -0.188284628721852 0.425648870616111 no 1949 0.425326767181402 2940 1948547
SGTC_455 paf C-16 10 µM -0.189205999191485 0.425297004255065 no 1950 0.424965682957457 2727 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3038 9091290 49.47 µM -0.189235286882403 0.425285820419681 no 1951 0.424954206169426 2876 25236843
SGTC_2244 6635614 200 µM -0.190279813128486 0.424886995655972 no 1952 0.424544935726304 2702 836499
SGTC_389 tpck 16.7 µM -0.190500843327385 0.424802610952153 no 1953 0.424458341203624 2810 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2064 5220758 200 µM -0.191143612926317 0.424557234566822 no 1954 0.424206539666326 2886 788518
SGTC_2271 7849410 118.62 µM -0.192108216665355 0.424189053336851 no 1955 0.423828719410922 2722 972430
SGTC_416 estradiol valerate 100 µM -0.192134418761763 0.42417905313586 no 1956 0.423818457433118 2813 13791 A steroid.
SGTC_1118 chelidonine 707.474 nM -0.192969217217113 0.423860472447704 no 1957 0.42349153803146 2784 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3215 9129942 49.47 µM -0.193540201453976 0.423642598731957 no 1958 0.423267962486556 2838 17682944
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.193936335492471 0.423491457315115 no 1959 0.42311286608995 2755 688664
SGTC_2641 levomentholum 100 µM -0.194021649754535 0.423458907890149 no 1960 0.423079464978342 2758 16666
SGTC_1031 k035-0009 16 µM -0.194945046327292 0.423106643549214 no 1961 0.422717984389215 2960 5180959
SGTC_1452 4194-0072 190 µM -0.195097545312314 0.42304847298382 no 1962 0.422658292105957 2923 1343545
SGTC_449 xestospongin c 11.1929 µM -0.195206479047733 0.423006921360743 no 1963 0.422615653542988 2879 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1106 tegaserod maleate 11.7 µM -0.195822207287383 0.422772074440774 no 1964 0.422374663836911 2800 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_707 0865-0008 204 µM -0.196790278559906 0.422402894739526 no 1965 0.421995829474162 2779 723043
SGTC_1246 0422-0085 105 µM -0.199595796356573 0.421333380048467 no 1966 0.420898357827284 2868 264295
SGTC_294 k038-0071 157 µM -0.199640368153351 0.421316393125433 no 1967 0.420880927021693 2806 24152826
SGTC_1646 st011709 75.6 µM -0.201692659448124 0.420534395884989 no 1968 0.420078500791152 2807 5757843
SGTC_1752 st044819 83.042 µM -0.203135842587261 0.419984678450064 no 1969 0.419514428688262 2805 441209 YML126C ERG13
SGTC_1382 3002-2117 298 µM -0.204054768173938 0.419634735235372 no 1970 0.419155350178078 2889 1497314
SGTC_234 nsc-17383 10.7 µM -0.205837563102006 0.418955996669348 no 1971 0.418458899156015 2912 408974
SGTC_2177 5811945 192 µM -0.206410511884068 0.418737917002717 no 1972 0.41823513016683 2931 5343475
SGTC_973 1325-0077 65.9 µM -0.206448748949473 0.418723363838636 no 1973 0.418220197365658 2833 2835149
SGTC_122 0236-0016 402.397 µM -0.207807686887329 0.418206219560366 no 1974 0.417689565185004 2813 6808838
SGTC_2110 5483698 200 µM -0.208318182587172 0.418011986734527 no 1975 0.417490267705947 2825 2848765 YHR062C RPP1
SGTC_2468 5987765 72.9 µM -0.20849768725019 0.4179436937528 no 1976 0.417420194134047 2823 26772094
SGTC_2966 9084041 48.03 µM -0.208511101268113 0.41793859045668 no 1977 0.417414957784002 2724 17741380
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.209044905091289 0.417735518682885 no 1978 0.41720659187183 2876 5379071
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.209083180332761 0.417720958705409 no 1979 0.417191652340185 2914 61125 An anti-inflammatory.
SGTC_2923 7992654 58.14 µM -0.210135127816153 0.417320840019741 no 1980 0.416781104733215 2819 2985126
SGTC_736 0958-0254 92.6 µM -0.211187309674101 0.416920717814988 no 1981 0.416370556428312 2892 6812352
SGTC_2255 7941087 197.44 µM -0.211506829087843 0.416799228444131 no 1982 0.416245901953827 2934 935561
SGTC_746 1095-0025 46.6 µM -0.212592656867167 0.416386428678802 no 1983 0.415822349748143 2963 6749286
SGTC_1605 st000082 49.1 µM -0.214496765681475 0.415662765420976 no 1984 0.415079844443576 2901 1114022
SGTC_1753 st043925 64 µM -0.215751569921778 0.415186028792989 no 1985 0.41459070037932 2888 670181
SGTC_104 0074-0074 590.992 µM -0.215909925986313 0.415125873575876 no 1986 0.414528979882289 2743 3943124
SGTC_314 1671-0008 2.74 µM -0.216313626712025 0.414972527514276 no 1987 0.414371643962535 2778 3913060
SGTC_2596 sinensetin 100 µM -0.218404626037429 0.414178467466839 no 1988 0.413556930741633 2849 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1866 st057638 64 µM -0.218993386287714 0.413954948034707 no 1989 0.413327599854916 2811 688802
SGTC_1744 st037937 38.9 µM -0.221232723925922 0.413105051619441 no 1990 0.412455615228623 2978 1016152
SGTC_236 1509-0011 5.31 µM -0.222434372988217 0.412649157000245 no 1991 0.411987878094468 2897 3107280
SGTC_819 1013-0258 27.7 µM -0.224232353324665 0.411967239957455 no 1992 0.411288255022156 2822 5753198
SGTC_364 0083-0097 67.7 µM -0.224404760080237 0.411901865461445 no 1993 0.411221183563302 2948 5207356
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.227297255885916 0.410805433044271 no 1994 0.410096303379063 3226 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2371 9071574 200 µM -0.228262407715482 0.410439736169683 no 1995 0.409721123709746 2902 45596039
SGTC_1210 3013-0140 750 nM -0.228851021432524 0.410216748114677 no 1996 0.409492354767748 2965 905973
SGTC_2170 morpholine 200 µM -0.228910100803384 0.41019436832498 no 1997 0.409469394847001 2932 121171 Reacts with secondary amines.
SGTC_1838 st055369 84.5 µM -0.229353035212489 0.410026590163534 no 1998 0.409297267856769 2792 676036
SGTC_1009 4106-0057 9.87 µM -0.22952094045054 0.40996299400701 no 1999 0.409232023434438 2821 2928005
SGTC_2499 avocadenofuran 51.48 µM -0.229759178446427 0.409872762525271 no 2000 0.409139453505924 2797 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_450 aminopyrene 156 nM -0.234339456046808 0.408138938014725 no 2001 0.407360728525239 2911 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1138 3761-0006 1.03 µM -0.23547996672306 0.407707485683156 no 2002 0.406918112987746 2795 12061087
SGTC_876 0720-0963 56.8 µM -0.235492859406517 0.40770260905203 no 2003 0.406913110203944 3023 765861
SGTC_2817 7995342 71.43 µM -0.23585279534318 0.407566469796281 no 2004 0.406773449395953 2790 18879975
SGTC_1268 0828-0275 2.46 µM -0.235907137403752 0.40754591686453 no 2005 0.406752364850889 2928 745337
SGTC_1418 3966-3099 2.4 µM -0.236754991783972 0.40722527940541 no 2006 0.406423435117353 2901 740335
SGTC_1871 st057448 67.3 µM -0.237634127713509 0.406892877682945 no 2007 0.406082439258304 3010 691747
SGTC_621 3584-0052 32.1 µM -0.237806035895143 0.406827886947026 no 2008 0.406015768493133 2885 2273927
SGTC_2568 diosmetin 100 µM -0.237844744659917 0.406813253261448 no 2009 0.406000756535441 2953 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_561 1550-0330 72.9 µM -0.238233683917946 0.406666223637089 no 2010 0.405849926545291 2827 6812934
SGTC_3045 9092950 49.47 µM -0.238644617997273 0.40651089366492 no 2011 0.405690582183688 2919 44120432
SGTC_299 1273-0059 1.44 µM -0.239779894075806 0.406081844422432 no 2012 0.405250447268306 2933 2848077
SGTC_3007 9078383 71.4286 µM -0.241275862668712 0.405516652724594 no 2013 0.404670658576275 2865 6496995
SGTC_734 2023-0417 80 µM -0.24328916482101 0.404756318366174 no 2014 0.403890698749317 2960 3935732
SGTC_3133 9127736 49.47 µM -0.243851457134137 0.404544029751875 no 2015 0.403672932975967 2879 27243420
SGTC_911 3456-4043 236 µM -0.244365756483089 0.404349885068164 no 2016 0.403473780162409 2932 914281
SGTC_1445 4239-0156 97.7 µM -0.244389703776836 0.404340845692876 no 2017 0.403464507629765 3020 4008346
SGTC_885 0865-0106 16.8 µM -0.24549550268148 0.403923495926134 no 2018 0.403036394996493 2842 2793380
SGTC_962 1254-0300 21.5 µM -0.246541046825389 0.403528988025394 no 2019 0.402631717004648 2824 7340576
SGTC_228 caffeine 993.056 µM -0.246554334646917 0.403523974854825 no 2020 0.402626574621981 2966 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2916 7875993 68.79 µM -0.250139797870337 0.402171848934602 no 2021 0.401239619882589 2863 1299250
SGTC_1112 tnp00069 1.16933 µM -0.250199165905905 0.402149470259013 no 2022 0.401216665129034 2954 145826
SGTC_652 0437-0092 114 µM -0.250754080848211 0.401940311576741 no 2023 0.401002122805754 2857 3091274
SGTC_1733 st037357 54.9 µM -0.251056678292534 0.401826268297847 no 2024 0.400885144550609 2803 1272339 YGL099W LSG1
SGTC_1337 1486-1011 40.3 µM -0.252261591948383 0.401372242032929 no 2025 0.400419436732157 2849 X1337
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.252766620788044 0.401181980522201 no 2026 0.400224281499696 2842 165521
SGTC_86 0417-1630 471.922 µM -0.253777233080005 0.400801318958661 no 2027 0.399833831566779 2889 3634867
SGTC_947 3447-0010 211 µM -0.253985302133785 0.400722958454495 no 2028 0.399753456530814 2819 748350
SGTC_1670 st016595 4.04 µM -0.254027789421308 0.400706957886229 no 2029 0.399737044630212 2884 597879
SGTC_2318 6029776 164 µM -0.254961744458216 0.400355275715854 no 2030 0.399376323222605 3044 818325
SGTC_218 alverine citrate 93.75 µM -0.255470993334682 0.400163551298274 no 2031 0.399179672217881 2990 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3117 9124945 49.47 µM -0.255919529038692 0.399994704387778 no 2032 0.399006487334902 2813 17592065
SGTC_1033 k072-0102 21.3 µM -0.256750366675725 0.399681993034495 no 2033 0.398685743741237 3043 5965931
SGTC_1976 st070609 63.5 µM -0.257194888459616 0.399514709965875 no 2034 0.398514164869426 2783 682556
SGTC_283 0987-0079 11.7 µM -0.258021917951002 0.399203530158599 no 2035 0.398194995867034 2952 411556
SGTC_1012 4112-3522 18 µM -0.258619560699155 0.398978699722932 no 2036 0.39796439466625 3020 3112398
SGTC_2192 5915882 198.485 µM -0.259369988852641 0.398696439590457 no 2037 0.397674891506001 2844 2876149
SGTC_2190 6049624 200 µM -0.25956593002341 0.398622748538838 no 2038 0.39759930981137 2915 2265554
SGTC_1720 st037298 9.481 µM -0.25997748746499 0.398467978645002 no 2039 0.397440569534002 2960 597396
SGTC_2536 dehydroabietamide 32.04 µM -0.261162941852174 0.398022267135419 no 2040 0.396983427370219 3015 3983547
SGTC_2795 7780010 54.55 µM -0.262600728276372 0.397481861481816 no 2041 0.39642916933645 3014 953673
SGTC_844 0330-0132 15.3 µM -0.263959159824867 0.39697146280397 no 2042 0.395905694337957 2998 2828079
SGTC_1370 2001-0092 44.6 µM -0.265497531970729 0.396393668742295 no 2043 0.395313105431566 3093 790957
SGTC_132 0417-1715 25.805 µM -0.266107503932519 0.396164633521652 no 2044 0.395078208000587 2994 6769098
SGTC_3125 9127534 49.47 µM -0.266953123103825 0.395847175639004 no 2045 0.394752626980198 2899 1639235
SGTC_2020 4017018 200 µM -0.266980014382898 0.395837081389188 no 2046 0.394742274481316 2982 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1612 st002233 45.4 µM -0.267957199159108 0.395470320425385 no 2047 0.394366132206487 2882 1035021
SGTC_1262 0737-0114 49.6 µM -0.268399849236256 0.395304213638741 no 2048 0.394195777774087 3027 765919
SGTC_1854 st056233 32.9 µM -0.268600818538655 0.395228805119667 no 2049 0.394118441166422 2964 5393174
SGTC_1458 k015-0034 6.33 µM -0.26869846099797 0.39519216873493 no 2050 0.394080868095882 2934 3598957
SGTC_679 0422-0091 41.4 µM -0.269672830639245 0.394826626725758 no 2051 0.393705982195401 2871 627384 YHR062C RPP1
SGTC_2952 9073731 13.78 µM -0.270121561488565 0.394658313125252 no 2052 0.393533367403736 2913 16457353
SGTC_2993 9054257 71.4286 µM -0.272722637404311 0.393683068740512 no 2053 0.392533215991467 2871 6470217 YGL055W OLE1
SGTC_669 0108-0021 26.2 µM -0.272991944480549 0.393582133030641 no 2054 0.392429703925089 3032 17201
SGTC_2477 5967686 25.23 µM -0.273282483981535 0.393473247472374 no 2055 0.392318039403028 2859 776118
SGTC_2425 5628681 7.85 µM -0.273790494686717 0.393282880201033 no 2056 0.39212281437719 2970 5714958
SGTC_158 k038-0087 26.446 µM -0.2737921468487 0.393282261126605 no 2057 0.392122179506954 2862 X158
SGTC_127 0180-0333 59.125 µM -0.276286161715593 0.392348048166716 no 2058 0.391164141887136 2886 771601
SGTC_1503 4585-0012 61.3 µM -0.277117249523171 0.392036875145804 no 2059 0.390845038554369 3080 2922052
SGTC_3355 9151058 44.0485 µM -0.277400182024655 0.391930956279906 no 2060 0.390736420936172 2900 17015728
SGTC_3349 9149703 23.001 µM -0.277538611358072 0.391879136667282 no 2061 0.390683281103028 2854 4910494
SGTC_1079 idarubicin 2.36 µM -0.281584878325775 0.390365308779515 no 2062 0.389130918278652 2996 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3031 9088762 49.47 µM -0.281908758431953 0.390244207157329 no 2063 0.389006736775239 2850 205253
SGTC_3091 9116372 49.47 µM -0.284398514833001 0.389313621746201 no 2064 0.388052498512069 3065 17169793
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.287195490367312 0.388268965234074 no 2065 0.386981319554751 2918 1241132 A phosphatase inhibitor.
SGTC_2959 9079155 11 µM -0.288290460005667 0.387860219101092 no 2066 0.386562204563068 3074 16189457
SGTC_186 3455-3465 67.277 µM -0.288679774298439 0.38771492013266 no 2067 0.386413220908719 2899 755278
SGTC_2954 9074818 52.69 µM -0.291625029849156 0.386616209497399 no 2068 0.385286667923158 3090 16648742
SGTC_1239 0337-0584 35.4 µM -0.292211211297636 0.386397645972909 no 2069 0.38506257008369 3096 914301 YML130C ERO1
SGTC_222 nsc-310342 10.666 µM -0.292215262716556 0.386396135486797 no 2070 0.38506102135507 2994 432556
SGTC_1807 st050092 58.9 µM -0.294507487820866 0.385541804367057 no 2071 0.384185071273748 2943 5008496
SGTC_2470 5664817 21.68 µM -0.295234623818658 0.385270910571158 no 2072 0.383907327085458 2899 2859561
SGTC_680 0417-1641 114 µM -0.295277501684433 0.385254938211048 no 2073 0.383890950884187 2901 2835990
SGTC_393 acivicin 6.25 µM -0.295638443544781 0.385120492097036 no 2074 0.383753105776221 2913 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3340 9146634 11.102 µM -0.296162627627291 0.384925264985943 no 2075 0.383552944020554 3003 4907387
SGTC_2243 6634756 200 µM -0.298741277233781 0.38396529834794 no 2076 0.382568729861389 3191 885676
SGTC_1256 0570-0116 285 µM -0.298996423686568 0.383870352305252 no 2077 0.382471387148487 2959 410638
SGTC_597 k018-0003 82.8 µM -0.29916105920412 0.383809091226543 no 2078 0.382408579838678 3047 6786234
SGTC_108 0509-0257 621.132 µM -0.299184291935763 0.383800446532259 no 2079 0.382399716961473 3021 536624
SGTC_551 k048-0028 34.9 µM -0.300967925396753 0.383136945211973 no 2080 0.381719476508061 3089 6836383
SGTC_1901 st060216 58.6 µM -0.302906591544886 0.382416161318104 no 2081 0.380980523941048 2918 688792
SGTC_1484 3473-2379 286 µM -0.305773647923338 0.381350954767552 no 2082 0.379888496994765 2978 671917
SGTC_1694 st024011 44.9 µM -0.306124476930974 0.381220671670456 no 2083 0.37975493603584 3018 2787533
SGTC_101 0490-5701 117.494 µM -0.306432411477604 0.381106328859226 no 2084 0.379637716861192 2952 4661669
SGTC_251 melphalan 456.522 µM -0.307088871038215 0.380862605772694 no 2085 0.379387864172639 3007 460612 A DNA alkylator.
SGTC_1175 0741-0056 27.6 µM -0.307175903674245 0.380830296799093 no 2086 0.379354742776257 3143 765927
SGTC_971 1315-0384 26.7 µM -0.307514542596821 0.380704592371362 no 2087 0.379225877777648 2966 6769120
SGTC_1660 st012960 28.1 µM -0.307556868929645 0.38068888151425 no 2088 0.379209771940222 3037 24207266
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.308908370812167 0.380187329224011 no 2089 0.378695614520523 3130 688798
SGTC_2011 4012611 177 µM -0.30913344129905 0.380103823450823 no 2090 0.378610010852508 2929 2049887
SGTC_2341 7987486 176.74 µM -0.31056626369506 0.379572348105553 no 2091 0.378065188705584 3114 1258686
SGTC_2082 5219693 150 µM -0.31123379526528 0.379324818908667 no 2092 0.377811446523281 2944 2834649
SGTC_2738 aclarubicin 5.55 µM -0.311419709183609 0.379255888464754 no 2093 0.377740786282178 3017 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2279 7948423 32.93 µM -0.311570294597689 0.379200059420633 no 2094 0.377683556332539 3152 1247112
SGTC_835 0312-0010 67.2 µM -0.311779487113667 0.3791225061686 no 2095 0.377604057224384 2927 1626196
SGTC_1379 2144-0755 36.5 µM -0.312021955284647 0.379032622830184 no 2096 0.377511918908392 3140 5392327
SGTC_2925 9010536 32.5 µM -0.312144520488502 0.378987190201625 no 2097 0.377465346575163 3014 2994177
SGTC_1126 isoteolin 1.0172 µM -0.312976738471247 0.378678746805139 no 2098 0.377149167491914 2952 133323
SGTC_2898 9056270 58.44 µM -0.316166980910411 0.377497070564299 no 2099 0.375937884319368 2966 19154699
SGTC_2972 9093619 59.92 µM -0.317669732259429 0.37694084284511 no 2100 0.375367736477213 2939 25236256
SGTC_1057 3448-5381 134 µM -0.318968194869074 0.376460436012223 no 2101 0.374875315419905 3097 5497911
SGTC_1196 1588-0294 184 µM -0.319206514613684 0.376372282928077 no 2102 0.37478495861499 3012 6144269
SGTC_166 k072-0058 166.424 µM -0.320180579790499 0.376012048978866 no 2103 0.374415722001581 3079 5846229
SGTC_742 0kpi-0133 140 µM -0.321152937301993 0.375652554291622 no 2104 0.374047247544446 3126 2728852
SGTC_2951 9072950 58.06 µM -0.321219943280703 0.375627785179957 no 2105 0.374021859891489 2988 16488155
SGTC_3116 9124943 49.47 µM -0.321274055085233 0.37560778284155 no 2106 0.374001358064372 2985 41905195 YPL160W CDC60
SGTC_1873 rapamycin 2 nM -0.321890826942809 0.375379817787197 no 2107 0.373767701348014 2984 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_144 4161-2749 112.381 µM -0.322032877237686 0.375327320737515 no 2108 0.373713893844224 2990 797501 YMR168C CEP3
SGTC_1737 st035557 69.7 µM -0.32232191532542 0.375220509033074 no 2109 0.373604416152797 2948 5716916
SGTC_2077 5212015 200 µM -0.322386392223481 0.375196683417925 no 2110 0.373579995911337 2919 780900
SGTC_3047 9092122 49.47 µM -0.323149705124429 0.374914658919069 no 2111 0.373290934292709 3044 17173831
SGTC_2515 chrysin 20.77 µM -0.323436376027094 0.374808758654114 no 2112 0.373182392298023 3046 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_3254 9136651 49.47 µM -0.323777176877342 0.374682874306866 no 2113 0.373053368214696 3016 16454030
SGTC_2365 9042475 200 µM -0.324706945324548 0.374339506213899 no 2114 0.37270143882743 3097 6464479
SGTC_90 0870-0863 4.608 µM -0.324778712619109 0.374313006335718 no 2115 0.372674278390797 2936 1738164
SGTC_1658 st012944 20 µM -0.325041437390646 0.37421600099541 no 2116 0.372574855221903 3051 24207260
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.325558084112762 0.374025263795188 no 2117 0.372379364912912 3100 5024745
SGTC_3032 9089427 49.47 µM -0.32646959279856 0.373688825484954 no 2118 0.372034545772935 3081 17173707
SGTC_9 0092-0002 10.449 µM -0.326622100885299 0.373632544064575 no 2119 0.371976862744635 3034 759368
SGTC_1635 st007035 42.4 µM -0.326839238825012 0.373552416362915 no 2120 0.371894739769698 3053 3716403
SGTC_3300 9124615 50.48 µM -0.327082882082359 0.373462514242812 no 2121 0.371802599250678 3164 24824903
SGTC_2529 gangaleoidin 93.61 µM -0.327270714431975 0.373393210534894 no 2122 0.371731570200951 2954 4565183
SGTC_2290 7904846 200 µM -0.328183091015534 0.373056633097374 no 2123 0.371386615950839 3037 2962154
SGTC_3207 9114163 49.47 µM -0.329460699844308 0.372585483628151 no 2124 0.370903747144634 3244 849233
SGTC_1406 3909-7906 11.9 µM -0.330536360216334 0.372188955331476 no 2125 0.37049736174869 3021 X1406
SGTC_1193 1488-0126 41.5 µM -0.332586808105032 0.371433459811798 no 2126 0.369723101311316 3018 1384710
SGTC_3169 9102970 49.47 µM -0.334283331510446 0.370808743231392 no 2127 0.369082883615814 3024 17027839
SGTC_1640 st009078 66.4 µM -0.335523179938785 0.370352404817244 no 2128 0.368615231007433 3119 690618
SGTC_1500 4488-1866 171 µM -0.336577741723929 0.36996440649078 no 2129 0.368217618846698 3125 2900003
SGTC_2803 7707263 71.43 µM -0.336786235695847 0.369887712260628 no 2130 0.368139024936849 3001 2199229
SGTC_2449 5812982 45.77 µM -0.337490384465957 0.369628730338484 no 2131 0.367873629750754 3087 776185
SGTC_1459 k035-0031 35.7 µM -0.338288982783919 0.369335081974729 no 2132 0.367572712650464 2973 3877128 YMR208W ERG12
SGTC_53 0973-0023 39.979 µM -0.338612143172871 0.369216276029296 no 2133 0.367450966781445 3118 674768
SGTC_926 2268-1401 59.4 µM -0.33875996264996 0.369161936178069 no 2134 0.367395282432188 2991 2931578
SGTC_765 1319-0117 244 µM -0.339338647094832 0.368949231411773 no 2135 0.367177315891557 3010 3487746 YGL099W LSG1
SGTC_3351 9150312 21.596 µM -0.340947752620722 0.368357989933219 no 2136 0.366571457426489 3076 4904905
SGTC_921 1561-0023 372 µM -0.341609299653903 0.368115004788174 no 2137 0.366322468850385 2979 24050882
SGTC_3255 9139072 49.47 µM -0.342066650884105 0.367947051263139 no 2138 0.366150366990463 3088 17646060
SGTC_743 1275-0778 158 µM -0.34276465409476 0.367690771552349 no 2139 0.365887759388078 3093 2849257 YMR203W TOM40
SGTC_537 1334-0398 209 µM -0.342868241469035 0.367652743302099 no 2140 0.365848792379259 3171 5846986
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.3430474401478 0.367586960238776 no 2141 0.365781385535455 3022 688669
SGTC_1235 benzylparaben 21.5 µM -0.343549173585586 0.367402796725828 no 2142 0.365592677021184 3087 7180
SGTC_2643 anethole 100 µM -0.343731604224659 0.36733584229738 no 2143 0.365524070530404 3071 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2677 mitomycin C 100 µM -0.346270691933756 0.366404383484209 no 2144 0.364569646107834 3033 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_93 0109-0045 59.227 µM -0.346831947576169 0.366198594013919 no 2145 0.364358787239561 3051 88733
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.347005449269686 0.366134985827825 no 2146 0.36429361246282 2965 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_386 1509-0011 3.07 µM -0.347466454916972 0.365965992483509 no 2147 0.36412045777421 3013 3107280
SGTC_2701 st077767 14.721 µM -0.347930727020435 0.365795828013825 no 2148 0.363946104227735 3051 5721188
SGTC_616 4092-0450 108 µM -0.34871604322137 0.365508054948935 no 2149 0.363651249350323 3069 787165
SGTC_2104 5389443 200 µM -0.349341674700165 0.365278851277102 no 2150 0.363416407482207 3201 2244536
SGTC_994 3910-0338 138 µM -0.350602734946897 0.364817000938076 no 2151 0.362943202221971 3203 3479481
SGTC_2239 6685329 187.64 µM -0.352471469625191 0.364132956848933 no 2152 0.362242355637753 3153 805680
SGTC_3193 9111931 49.47 µM -0.352748697240963 0.364031515404477 no 2153 0.362138423993643 2996 17087244
SGTC_1865 st057639 52.2 µM -0.354390398233183 0.363430989622752 no 2154 0.361523164678437 3013 688818
SGTC_2455 5377712 9.75 µM -0.354398825063378 0.363427907995751 no 2155 0.36152000748215 3090 2243908
SGTC_246 cycloheximide 667 µM -0.35549793958684 0.363026046087233 no 2156 0.361108294112834 3006 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1275 0867-0008 21.1 µM -0.356918904221512 0.362506731769653 no 2157 0.360576258507951 2997 3422836
SGTC_2008 4012253 172 µM -0.357748308934312 0.362203729323705 no 2158 0.360265838570236 3015 603940
SGTC_3305 9127027 53.8275 µM -0.358720147310994 0.361848802109279 no 2159 0.35990222740733 3047 41905295
SGTC_1608 st001473 40.5 µM -0.360330146969789 0.361261072159469 no 2160 0.35930012866655 3046 7292267
SGTC_1047 2043-3044 82 µM -0.360908595742194 0.361049989439621 no 2161 0.359083888801169 3058 669592
SGTC_1311 1190-0148 100 µM -0.361468642839991 0.360845662014061 no 2162 0.358874570988975 3170 1961333
SGTC_2791 5663188 71.43 µM -0.362942788015458 0.360308025267403 no 2163 0.358323811366727 3213 54690634
SGTC_1928 4'-methoxychalcone 40.3 µM -0.363156958943219 0.360229937752515 no 2164 0.358243818834441 3249 641818
SGTC_295 k015-0027 31 µM -0.363214828454722 0.360208839314371 no 2165 0.358222205722945 3110 3887424
SGTC_343 4130-2827 29.8 µM -0.364261866262133 0.359827177142981 no 2166 0.35783123645631 3088 1118244
SGTC_1209 2323-2347 50.3 µM -0.365773357998357 0.359276460547648 no 2167 0.357267100769147 3147 5412760
SGTC_1691 st019933 84.6 µM -0.366092298568484 0.359160290884522 no 2168 0.357148102037978 3139 6176082
SGTC_861 0443-0273 110 µM -0.366985823328297 0.358834906295195 no 2169 0.356814796353052 3143 6149169
SGTC_1628 st004252 77.7 µM -0.36831922067668 0.358349528891268 no 2170 0.356317611161341 3179 692968
SGTC_909 3448-9333 149 µM -0.369377261617562 0.357964548255691 no 2171 0.355923272052227 3032 3344074
SGTC_545 4218-0007 221 µM -0.370177940249636 0.357673307883958 no 2172 0.35562495604105 3179 2840508
SGTC_1756 st041558 35.5 µM -0.370797403238922 0.357448040069328 no 2173 0.355394217813946 3242 3955792
SGTC_2099 5377090 177.372 µM -0.371964400254362 0.357023796373986 no 2174 0.354959677550919 3146 2243829
SGTC_3108 9121785 49.47 µM -0.372098730946787 0.356974973863313 no 2175 0.354909670583857 3058 17140271
SGTC_1567 st069303 68.4 µM -0.372717529384552 0.356750101733649 no 2176 0.354679344251555 3150 5581319
SGTC_789 1309-1135 70.6 µM -0.373832190724237 0.356345158030172 no 2177 0.354264584156779 3046 3092424
SGTC_3236 9132701 49.47 µM -0.374210200405762 0.356207868185356 no 2178 0.354123967795228 3131 24282524
SGTC_2383 9036125 200 µM -0.374396063388847 0.356140371192212 no 2179 0.354054835651439 3054 79580
SGTC_1518 st038567 90.8 µM -0.374678461981518 0.35603782547864 no 2180 0.353949806083964 3133 77966
SGTC_2457 5731572 11.68 µM -0.374820953760094 0.355986087242647 no 2181 0.353896814818461 3182 2865357
SGTC_2861 9024595 19.48 µM -0.374852510749043 0.355974629375734 no 2182 0.353885079473051 3088 16482810
SGTC_3112 9123419 49.47 µM -0.37506369365619 0.355897955394529 no 2183 0.353806548799646 3040 17015854
SGTC_1806 st050005 60.3 µM -0.375146926841089 0.355867737600756 no 2184 0.353775599338301 3071 5194765
SGTC_2894 9048625 32.47 µM -0.375769435190381 0.355641764773275 no 2185 0.353544156234629 3237 4092861
SGTC_1092 toremifene 6.32 µM -0.378074898707508 0.354805315363597 no 2186 0.352687477356223 3050 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3002 9075603 71.4286 µM -0.378221166367053 0.354752271282547 no 2187 0.352633151421799 3102 20105405
SGTC_474 dl-dihydrosphingosine 5 µM -0.378825140618317 0.354533269379336 no 2188 0.35240885844451 3218 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2531 methyl deoxycholate 70.07 µM -0.380056094663947 0.354087072651549 no 2189 0.351951888045608 3038 16667744 Haematoxylin.
SGTC_1524 corynanthine 62.1 µM -0.383181806226312 0.352954964607376 no 2190 0.350792483483793 3224 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_403 arphamenine a 50 µM -0.38419751261246 0.352587363255282 no 2191 0.350416030881449 3088 5487158 An arginine aminopeptidase inhibitor.
SGTC_2313 7726885 200 µM -0.386166971709298 0.351874975015038 no 2192 0.349686506446251 3155 726423
SGTC_288 1315-0019 35.1 µM -0.386203219078401 0.351861868562501 no 2193 0.349673084934088 3183 6811474
SGTC_2348 9022543 33.42 µM -0.387380219898499 0.351436380162311 no 2194 0.349237372572458 3200 3162678 YDL140C RPO21
SGTC_1697 st025554 27.742 µM -0.387385844442446 0.351434347323591 no 2195 0.34923529090647 3055 1269519
SGTC_3250 9135583 49.47 µM -0.387997071695733 0.351213461159548 no 2196 0.349009100319991 3222 7699353
SGTC_2266 7929956 200 µM -0.388979516989618 0.350858529022318 no 2197 0.348645649309247 3073 2967153
SGTC_955 1216-0110 33 µM -0.389211844602588 0.350774614060298 no 2198 0.348559721094031 3065 3619719
SGTC_182 3448-4371 550.524 µM -0.390092566521253 0.350456570151172 no 2199 0.348234049676297 3157 3491403
SGTC_1766 st045414 44.774 µM -0.392990912903629 0.349410668215625 no 2200 0.347163096506473 3110 253960
SGTC_2397 5161689 200 µM -0.394186659375148 0.348979501617047 no 2201 0.346721617140897 3305 2259942
SGTC_1322 1348-1070 12 µM -0.395453120474188 0.348523049018958 no 2202 0.346254256228306 3212 6758089
SGTC_2063 5246145 200 µM -0.395484893025351 0.348511600505702 no 2203 0.346242534240883 3208 711240
SGTC_2223 6903751 107.57 µM -0.395577494412856 0.348478234497512 no 2204 0.346208371242857 3173 5598863
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.396199347877062 0.348254199469727 no 2205 0.345978986175301 3165 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1644 st010134 20.9 µM -0.396268390732369 0.348229328677291 no 2206 0.345953521601329 3233 3818134
SGTC_1834 st055981 52.8 µM -0.398149751744402 0.347551871560635 no 2207 0.345259901396151 3263 471719 YDL150W RPC53
SGTC_2685 mycophenolic acid 18.85 µM -0.401039700260037 0.346512181701265 no 2208 0.344195447505247 3132 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1736 st036774 51 µM -0.401152509369222 0.34647162079618 no 2209 0.344153921514482 3322 1272247
SGTC_135 0933-0004 26.348 µM -0.401679518228526 0.346282156267128 no 2210 0.343959949982052 3227 21230617 YGL099W LSG1
SGTC_2762 leflunomide 42.06 µM -0.402656884536961 0.34593088593074 no 2211 0.343600328040974 3099 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1261 0712-0010 12.7 µM -0.402829922797914 0.34586870891811 no 2212 0.343536673346755 3288 2840123
SGTC_235 0330-0087 5 mM -0.403533232298709 0.345616034863624 no 2213 0.343277996183729 3141 46494818 YHR062C RPP1
SGTC_365 0121-0052 13.6 µM -0.403689726868632 0.345559821287108 no 2214 0.343220447476866 3228 3101739
SGTC_2543 pimpinellin 60.67 µM -0.404932477101682 0.345113540623072 no 2215 0.342763572485379 3099 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1330 1469-0054 61.8 µM -0.40747269287236 0.34420200106854 no 2216 0.341830423121664 3245 7102664
SGTC_3000 9075062 71.4286 µM -0.407537525086586 0.344178748273331 no 2217 0.341806619592053 3117 17057871
SGTC_943 3253-1379 105 µM -0.407878356975123 0.344056514814214 no 2218 0.341681491501081 3284 668464
SGTC_1058 3448-5425 97.3 µM -0.408458277288785 0.343848573880098 no 2219 0.341468627925256 3158 7279705
SGTC_855 0428-0020 25 µM -0.40907100631723 0.34362892009565 no 2220 0.341243776470275 3141 6812414
SGTC_756 0508-1999 28.3 µM -0.41064306966904 0.343065601546127 no 2221 0.340667138717637 3116 6753853
SGTC_527 4476-4215 268 µM -0.411147077645764 0.342885073756366 no 2222 0.34048234573754 3124 4418754
SGTC_2367 9070478 135.38 µM -0.413501414873927 0.342042262558896 no 2223 0.339619643009626 3110 572802
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.413663988674913 0.341984092985836 no 2224 0.339560101828146 3146 5355888
SGTC_2854 9024559 71.43 µM -0.413857640501361 0.34191480846227 no 2225 0.339489183826923 3211 3163529
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.415065734908437 0.341482698138668 no 2226 0.339046891207405 3230 229346 A bile salt which induces apoptosis.
SGTC_1923 st058458 19.1 µM -0.415580163418967 0.341298760742417 no 2227 0.338858622266403 3330 3534982
SGTC_1008 4106-0037 6 µM -0.416620853302365 0.340926770334585 no 2228 0.338477876933298 3059 2905394
SGTC_3010 9080089 71.4286 µM -0.41847166440308 0.340265587500904 no 2229 0.337801149782616 3228 17027233
SGTC_1446 4239-0190 62 µM -0.418618481595462 0.340213159584818 no 2230 0.337747490219641 3132 1340085
SGTC_894 0960-0238 55.9 µM -0.418896076148392 0.340114039963731 no 2231 0.337646042433763 3263 6741907 YDL195W SEC31
SGTC_2534 helenine 20.12 µM -0.42280567538391 0.338719230729276 no 2232 0.336218523274027 3122 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_413 propylparaben 100 µM -0.422962019372071 0.338663498432802 no 2233 0.336161486014866 3135 7175 A pharmaceutical preservative.
SGTC_265 mycophenolic acid 32.932 µM -0.426540420846492 0.337388865369529 no 2234 0.334857050469145 3386 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2512 diallyl trisulfide 49.23 µM -0.431672660666977 0.335564008182392 no 2235 0.332989670176212 3234 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2423 st077119 87.2 µM -0.431792790184372 0.33552134025326 no 2236 0.332946010044601 3207 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1499 4480-0877 67.3 µM -0.432311821437427 0.335337013704429 no 2237 0.332757398239914 3158 2861909
SGTC_3186 9110464 49.47 µM -0.432708378153807 0.335196208946907 no 2238 0.332613321216459 3281 17018021
SGTC_904 1141-0088 396 µM -0.433640834259712 0.334865214508339 no 2239 0.332274638612727 3196 1378119
SGTC_2516 gossypol 71.55 µM -0.434395101038116 0.334597565837277 no 2240 0.332000777313129 3303 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1880 MG-132 525 µM -0.434963750592171 0.334395838272065 no 2241 0.331794369744909 3279 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2933 9026794 32.47 µM -0.435247823114476 0.334295081880355 no 2242 0.331691276640423 3173 17586027
SGTC_1534 6-azauridine 81.6 µM -0.435468240271443 0.334216911345119 no 2243 0.331611293563311 3189 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3124 9127567 49.47 µM -0.435780208504081 0.334106284681104 no 2244 0.331498102343955 3314 17592030
SGTC_1723 st034307 2.5525 µM -0.43597221977641 0.334038202968431 no 2245 0.331428442675261 3210 867466
SGTC_2846 9008642 19.48 µM -0.438258926119413 0.333227822555119 no 2246 0.330599298494298 3275 2992898
SGTC_2967 9089538 49.85 µM -0.438388345560603 0.333181981133953 no 2247 0.33055239668403 3352 728216
SGTC_205 1486-1330 71.903 µM -0.438646548449808 0.333090531011946 no 2248 0.330458831499229 3181 4118834
SGTC_46 0329-0187a 2.197 µM -0.439237837056398 0.332881146212506 no 2249 0.330244605706504 3245 46494817
SGTC_908 3448-7491 47.7 µM -0.439351154575641 0.332841024605071 no 2250 0.330203556749713 3159 1203031
SGTC_3238 9133470 49.47 µM -0.440213383826093 0.332535803338929 no 2251 0.329891283561867 3292 3534688
SGTC_569 4130-2812 160 µM -0.441319382362335 0.332144452488793 no 2252 0.329490898082244 3224 743552
SGTC_2235 salicylic acid 500 µM -0.441603662303693 0.33204389130807 no 2253 0.329388016690533 3246 338 A COX inhibitor and kinase inhibitor.
SGTC_1743 st037606 46.3785 µM -0.444810597037434 0.330910309605808 no 2254 0.328228317779616 3176 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_355 1311-2252 105 µM -0.44549161426513 0.330669783815018 no 2255 0.327982259282371 3197 5338538
SGTC_2623 humulene 100 µM -0.446151048250003 0.330436947538809 no 2256 0.327744070159751 3249 6187145 An anti-inflammatory.
SGTC_1131 3454-3128 32.3 µM -0.446194061419778 0.33042176251082 no 2257 0.327728536133887 3308 710982
SGTC_2485 5633444 17.78 µM -0.449313200024972 0.329321352189119 no 2258 0.326602868444365 3245 5724239
SGTC_1786 berberine 21.6 µM -0.450336261056662 0.328960744549481 no 2259 0.326233998284587 3253 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_257 daunorubicin 18.5 µM -0.451221139165324 0.32864897182899 no 2260 0.325915087743574 3305 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1986 st071812 45 µM -0.45232432516681 0.328260448795785 no 2261 0.325517677238983 3269 11838594
SGTC_1070 indatraline 8.81 µM -0.452334845964883 0.328256744445865 no 2262 0.325513888192095 3223 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.452778241800358 0.328100641102069 no 2263 0.325354216361132 3214 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1295 1013-0063 9.78 µM -0.453812810772725 0.327736524242444 no 2264 0.324981781117009 3322 6826038
SGTC_1237 0330-0133 46.1 µM -0.454014100666701 0.327665699220754 no 2265 0.324909338925855 3180 X1237 YHR072W ERG7
SGTC_25 0118-0223 35.662 µM -0.45723057580243 0.326534806254626 no 2266 0.323752661798266 3349 5333628
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.457263723098847 0.326523160140336 no 2267 0.323740750526653 3381 94937 An inhibitor of serotonin biosynthesis.
SGTC_3175 9106517 49.47 µM -0.458007057871979 0.326262038118635 no 2268 0.323473685309916 3283 41468073
SGTC_316 k060-0003 58.6 µM -0.460744194829086 0.325301258965428 no 2269 0.322491071686415 3317 6152314
SGTC_275 trichlorophene 5.69 µM -0.461498537631074 0.325036676126972 no 2270 0.322220485166174 3303 62616
SGTC_2646 retinol 96.75 µM -0.462098085633385 0.32482644987549 no 2271 0.322005491480972 3303 445354 A vitamin A analog and teratogen.
SGTC_2492 derrusnin 100 µM -0.462849567832286 0.324563028004587 no 2272 0.321736099378155 3238 1715307 Part of coumarin class of compounds.
SGTC_1516 st013856 110 µM -0.462904071326821 0.324543925956526 no 2273 0.321716564552354 3282 5281404 A mutagen and neurotoxin.
SGTC_401 neomycin 50 µM -0.463991006519086 0.324163080068113 no 2274 0.321327094536166 3237 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.464342390225558 0.324039999775832 no 2275 0.321201228906331 3160 6708514
SGTC_1146 3579-1023 7 µM -0.464606828430206 0.32394738684365 no 2276 0.321106520693009 3335 X1146
SGTC_786 4544-0069 423 µM -0.464621372625624 0.323942293415498 no 2277 0.32110131204507 3288 748821 YLR208W SEC13
SGTC_2537 larixol 68.93 µM -0.464709781712256 0.32391133295307 no 2278 0.321069651249853 3311 6708759
SGTC_1314 1222-0010 41.1 µM -0.464835594108041 0.323867276121198 no 2279 0.321024597937134 3252 3526027
SGTC_1651 st011928 86.1 µM -0.466482706590507 0.323290720079911 no 2280 0.320435011593026 3318 720198
SGTC_2915 7971052 15.16 µM -0.466635783991052 0.323237158313815 no 2281 0.320380240290473 3262 5741558
SGTC_3016 9080866 49.47 µM -0.467071364265033 0.323084768871626 no 2282 0.320224410482667 3213 17066299
SGTC_3182 9108849 49.47 µM -0.467175787145188 0.323048240534329 no 2283 0.320187057675807 3321 17133045
SGTC_851 0394-0702 453 µM -0.467506092909724 0.322932706976123 no 2284 0.320068916954097 3350 762646
SGTC_84 0443-0269 128.823 µM -0.468765369593962 0.322492397001815 no 2285 0.319618677906435 3326 6150058
SGTC_2038 4100038 30.985 µM -0.472016042853458 0.321356940583037 no 2286 0.318457668798797 3313 3596803
SGTC_3234 9132280 49.47 µM -0.472426191820649 0.321213794277852 no 2287 0.318311306433938 3300 17612295
SGTC_155 k072-0202 43.6 µM -0.472687013099005 0.321122778720234 no 2288 0.318218246660778 3309 5857737
SGTC_722 3534-0461 190 µM -0.472734251164156 0.321106295789193 no 2289 0.318201393574053 3276 658262
SGTC_1150 3909-7983 10.9 µM -0.473089283777881 0.320982424390792 no 2290 0.318074740918014 3251 23965914
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.473564031792917 0.320816815245438 no 2291 0.317905414796988 3316 521171
SGTC_1687 st020778 55.3625 µM -0.473974803181454 0.320673552208752 no 2292 0.31775893763018 3274 4259299
SGTC_1956 st077085 54 µM -0.474638462228538 0.320442147027083 no 2293 0.317522343392644 3256 24208685
SGTC_2638 epoxomicin 18 µM -0.475196875937215 0.320247492936805 no 2294 0.317323326807915 3316 9915668 A protesome inhibitor.
SGTC_420 mitomycin C 81.9 mM -0.475441885901004 0.320162101987268 no 2295 0.317236022824908 3219 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_617 3770-0098 35 µM -0.47872413585783 0.319019091109303 no 2296 0.316067446525059 3257 5962639
SGTC_953 1188-0045 9.7 µM -0.479747898499568 0.318662927096906 no 2297 0.315703332222404 3346 6144426
SGTC_73 0327-0325 16.231 µM -0.480117803751586 0.318534279314107 no 2298 0.315571814634784 3307 53298
SGTC_771 0250-0039 27.3 µM -0.480416357181832 0.318430462630464 no 2299 0.315465682789752 3238 3005115
SGTC_5 0352-0601 109.883 µM -0.480836209191225 0.318284490629423 no 2300 0.315316456639873 3288 762456
SGTC_526 4469-0568 170 µM -0.481071276042813 0.31820277610577 no 2301 0.315232921016985 3242 2901964
SGTC_487 nimodipine 119 µM -0.48308566847533 0.317502891078228 no 2302 0.314517454774982 3256 4497 L-type voltage-gated calcium channels inhibitor
SGTC_110 0850-0284 111.64 µM -0.483895807589811 0.317221598176997 no 2303 0.314229907932266 3167 3906265
SGTC_3155 9099265 49.47 µM -0.484991138607586 0.316841450066847 no 2304 0.313841315685464 3324 25236499
SGTC_727 3032-0951 202 µM -0.48578059481502 0.316567579412629 no 2305 0.313561367064278 3289 3652836
SGTC_1448 4255-0083 152 µM -0.486300686808807 0.316387208958098 no 2306 0.313376996178396 3382 5399660
SGTC_1348 1493-0373 93.8 µM -0.487660716813258 0.31591575037137 no 2307 0.312895090529063 3288 3010129
SGTC_1924 st058459 75.1 µM -0.487684487094979 0.315907512988973 no 2308 0.312886670735448 3338 688683
SGTC_584 0986-0246 15.4 µM -0.488753380516669 0.315537191890915 no 2309 0.312508153437233 3378 53315 YDR232W HEM1
SGTC_2999 9069765 71.4286 µM -0.488952238603117 0.315468317372396 no 2310 0.312437755471442 3289 2097066
SGTC_702 1488-0190 94 µM -0.490628826983897 0.314887885875391 no 2311 0.311844496939616 3351 949357
SGTC_452 diindolylmethane 8 µM -0.491040850104598 0.314745314195043 no 2312 0.311698777735842 3340 3071 Inhibits expression of several cancer promoting factors.
SGTC_3285 9112818 20.8695 µM -0.49109736407802 0.314725760910924 no 2313 0.31167879287643 3303 17017947 YPR165W RHO1
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.491198159834804 0.31469088785079 no 2314 0.311643150165506 3304 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_997 3996-0078 137 µM -0.492275839743022 0.314318138243951 no 2315 0.311262178666013 3292 735687
SGTC_1354 1498-1681 81 µM -0.493876338566228 0.313764904539707 no 2316 0.310696758000238 3341 5754243
SGTC_3136 9095672 49.47 µM -0.494023080148158 0.313714202285492 no 2317 0.310644939802143 3287 17217380
SGTC_639 0833-0042 114 µM -0.495223775521931 0.3132994694177 no 2318 0.310221084808832 3253 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3211 9128781 49.47 µM -0.495534296747515 0.313192250494411 no 2319 0.310111509339725 3289 17194361
SGTC_705 1124-0212 310 µM -0.496267289725926 0.312939220237236 no 2320 0.309852920638281 3399 9554485
SGTC_3321 9137793 26.8275 µM -0.497480724209216 0.312520534521967 no 2321 0.309425046293709 3355 4904192
SGTC_3329 9141233 27.5565 µM -0.497694976539354 0.312446633603368 no 2322 0.309349524666816 3393 4909101 YNL103W MET4
SGTC_886 0866-0150 153 µM -0.498003023824661 0.312340393707196 no 2323 0.309240955446454 3407 271463
SGTC_1023 4482-3888 16 µM -0.498065576771681 0.312318822240574 no 2324 0.309218911109643 3405 3303168
SGTC_431 k089-0097 107 µM -0.498809496097836 0.312062330007409 no 2325 0.308956798542527 3310 5499420
SGTC_2053 5265679 138 µM -0.499611137389723 0.311786038065379 no 2326 0.308674457074665 3268 764595
SGTC_1143 3454-2408 5.08 µM -0.500777213038429 0.311384330050854 no 2327 0.308263962151455 3348 X1143
SGTC_411 enrofloxacin 100 µM -0.500905405171132 0.311340182102558 no 2328 0.308218849143346 3434 71188 A bacterial gyrase inhibitor.
SGTC_1805 st050013 60.3 µM -0.501469845193439 0.311145827501136 no 2329 0.308020247491755 3302 4037144
SGTC_2111 5486399 200 µM -0.502990095124893 0.310622619203665 no 2330 0.307485618008537 3341 689674
SGTC_406 estrone 100 µM -0.504372943295137 0.31014703142864 no 2331 0.306999663792553 3407 5870 A steroid.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.507097186383999 0.309211041482509 no 2332 0.306043314551059 3258 279621
SGTC_2023 5144124 124 µM -0.507713151098379 0.308999580804362 no 2333 0.305827262116142 3256 2830192
SGTC_2078 5212016 200 µM -0.509325889822668 0.308446227494598 no 2334 0.305261906795888 3341 1899708
SGTC_3194 9111903 49.47 µM -0.510430494034387 0.308067473102675 no 2335 0.304874948890998 3437 17087251
SGTC_3309 9129340 25.759 µM -0.511423064490617 0.307727307889012 no 2336 0.304527423980173 3320 17158987
SGTC_2723 salbutamol 83.58 µM -0.512940657473836 0.307207530936275 no 2337 0.303996415993654 3363 9884233 β2-adrenoceptor agonist
SGTC_1774 st048371 48.465 µM -0.5149536005492 0.306518693428892 no 2338 0.303292721950723 3256 4242727
SGTC_1019 4262-0212 3.4 µM -0.515313426871191 0.306395631253459 no 2339 0.3031670089332 3398 4677213
SGTC_985 1493-0307 8.71 µM -0.516323618418737 0.306050258050996 no 2340 0.30281420153131 3434 3278274
SGTC_511 blebbistatin 171 µM -0.517637052162705 0.305601467456206 no 2341 0.302355762528664 3446 3476986 A myosin inhibitor.
SGTC_2832 7992762 51.95 µM -0.518585575226632 0.305277545605894 no 2342 0.30202488514059 3178 2985177
SGTC_2608 thymoquinone 42.66 µM -0.519213924231477 0.30506304752704 no 2343 0.301805785034252 3387 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.520749275039053 0.304539210064219 no 2344 0.301270721692225 3375 75037 A free radical scavenger.
SGTC_3009 9080819 71.4286 µM -0.521424956160482 0.304308805214098 no 2345 0.301035385096213 3360 17027216
SGTC_1228 0124-0032 52.5 µM -0.522480801361851 0.303948921282238 no 2346 0.30066780512891 3410 X1228
SGTC_982 1491-0518 27.5 µM -0.522507477586476 0.303939831172344 no 2347 0.300658520742495 3305 3091256
SGTC_2155 5570423 76 µM -0.523107548627445 0.303735384815815 no 2348 0.30044970637618 3306 797402
SGTC_2033 5192550 145 µM -0.525045334620229 0.303075593668416 no 2349 0.299775838100936 3319 182073
SGTC_3324 9138759 60.749 µM -0.525646487428473 0.302871039270606 no 2350 0.299566925402964 3415 45595710
SGTC_1557 sumaresinolic acid 42.3 µM -0.526576320901054 0.302554766433754 no 2351 0.299243919582098 3337 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1647 st011722 22.4 µM -0.527996796466528 0.302071893017346 no 2352 0.2987507797108 3431 2854783
SGTC_102 gallobenzophenone 83.616 µM -0.528415426079222 0.301929651012854 no 2353 0.298605516526217 3462 70837
SGTC_3065 9113888 49.47 µM -0.528717490750518 0.301827034147711 no 2354 0.298500720971791 3493 16648368
SGTC_2870 9038528 12.99 µM -0.528762154822922 0.301811862279916 no 2355 0.298485227047037 3421 6463316
SGTC_685 1278-0033 54.9 µM -0.52879760815548 0.301799819437746 no 2356 0.298472928579784 3453 3590572
SGTC_777 1315-0167 517 µM -0.529518199284292 0.301555094766523 no 2357 0.298223011471732 3369 4221767
SGTC_1240 0356-0016 42.1 µM -0.530661938803791 0.301166845326251 no 2358 0.297826532842844 3331 4305613
SGTC_3267 9137951 49.47 µM -0.531982877464208 0.300718725012009 no 2359 0.297368927309008 3315 16643986
SGTC_763 3453-1109 128 µM -0.536528670580912 0.299178897408228 no 2360 0.295796613259594 3465 1560353
SGTC_1282 0886-0010 32.4 µM -0.5366643696345 0.299132986188343 no 2361 0.295749735978517 3475 2836211 YNL267W PIK1
SGTC_1244 0416-0015 52.5 µM -0.536851999808254 0.299069510320111 no 2362 0.295684924698933 3339 96201
SGTC_3001 9076041 71.4286 µM -0.538625965539765 0.298469674702278 no 2363 0.295072483698195 3409 16004211
SGTC_178 4092-0806 87.505 µM -0.540473833701539 0.29784543299875 no 2364 0.294435150732903 3430 2169044
SGTC_2594 a-mangostin 100 µM -0.54247535338525 0.297169957674832 no 2365 0.293745540889066 3465 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_381 3461-2219 42.7 µM -0.54307603067111 0.29696737706853 no 2366 0.293538727567412 3426 2883159
SGTC_1950 st077106 7.18 µM -0.543359551861953 0.296871780464689 no 2367 0.293441134589063 3364 13831864
SGTC_345 1362-0200 395 µM -0.54503171292644 0.296308254199139 no 2368 0.29286585333364 3366 1419823
SGTC_1648 st011736 69.8 µM -0.546598991065163 0.295780519746452 no 2369 0.29232713119789 3486 2855514
SGTC_590 k048-0076 22.4 µM -0.54774434912443 0.295395127677702 no 2370 0.291933727780453 3437 6832814
SGTC_1049 3226-0134 66 µM -0.547820226467589 0.295369604498582 no 2371 0.291907674416874 3442 5702385
SGTC_3027 9089541 49.47 µM -0.547887887598672 0.295346845896889 no 2372 0.291884443098155 3449 9943819
SGTC_860 0443-0016 25.1 µM -0.548437008792708 0.295162172505125 no 2373 0.291695935258725 3427 5337942
SGTC_258 haloperidol 50.781 µM -0.548640126319527 0.295093876098507 no 2374 0.291626221412899 3390 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2576 guaiol 23.12 µM -0.549177116450396 0.294913353152848 no 2375 0.29144195348338 3370 227829
SGTC_733 4069-0007 56.1 µM -0.550048168527183 0.294620635035197 no 2376 0.291143167906766 3465 5717425 YNL287W SEC21
SGTC_2798 7813637 45.45 µM -0.550125981027216 0.2945944925719 no 2377 0.291116483866101 3446 956368
SGTC_3332 9141069 11.198 µM -0.550490011846374 0.294472204301649 no 2378 0.290991662886255 3354 17332883
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.550735485182516 0.29438975607923 no 2379 0.290907507696067 3355 6708630 An antioxidant.
SGTC_280 3448-3607 3.04 µM -0.550760581913351 0.294381327329057 no 2380 0.290898904469109 3452 626179
SGTC_1812 st052057 4.327 µM -0.5508930635624 0.294336835144616 no 2381 0.290853491373633 3396 3645418
SGTC_77 0828-0286 12.516 µM -0.55426289814857 0.293206166965984 no 2382 0.289699468966774 3437 745345
SGTC_3264 9137442 49.47 µM -0.554481640683758 0.293132842739537 no 2383 0.289624633452754 3523 17015726
SGTC_428 3448-4153 16.5 µM -0.556115755361761 0.292585343829104 no 2384 0.289065862567835 3299 3834874
SGTC_1137 ixabepilone 100 µM -0.556280609458716 0.292530136989424 no 2385 0.289009520352709 3467 154225 A novel microtubule stabilizer.
SGTC_1654 st012436 41.8 µM -0.558227868038932 0.291878399746656 no 2386 0.288344396664492 3439 4323132
SGTC_201 4262-0159 12.803 µM -0.55839054202288 0.291823984240883 no 2387 0.288288864911603 3398 1341029
SGTC_1770 st043884 66.3 µM -0.558453665156206 0.291802870415038 no 2388 0.288267318028729 3471 670149
SGTC_1897 st060201 15 µM -0.558662776879247 0.291732930484879 no 2389 0.288195943826442 3409 611878
SGTC_2416 tofa 880 nM -0.559494247281281 0.291454912527325 no 2390 0.287912228104495 3337 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_458 nppb 133 µM -0.561898159394946 0.290651814748536 no 2391 0.287092703909287 3540 4549 A chloride channel blocker.
SGTC_2907 7721985 69.9 µM -0.562346533624716 0.290502136725045 no 2392 0.286939969746377 3416 3267881
SGTC_2152 5568786 200 µM -0.562901914933424 0.290316787215803 no 2393 0.286750838089516 3429 5399883
SGTC_2781 5567276 71.43 µM -0.563000501722426 0.290283891261997 no 2394 0.286717271147909 3477 2853274
SGTC_2946 9065502 71.43 µM -0.563460270883781 0.290130500815301 no 2395 0.286560753030865 3341 16489101
SGTC_2385 9074692 200 µM -0.56417587143436 0.289891834238671 no 2396 0.286317223511503 3416 17046906
SGTC_1082 camptothecin 424.86 nM -0.564392607014166 0.289819566917082 no 2397 0.286243484558189 3295 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2690 usnic acid 100 µM -0.564498094140628 0.289784396829521 no 2398 0.286207598419535 3565 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_530 4358-1714 28 µM -0.567987350017827 0.288622186627285 no 2399 0.285021778785498 3463 1564641
SGTC_2823 7987624 58.44 µM -0.56829347671957 0.288520326023946 no 2400 0.28491785385943 3546 2239440
SGTC_1718 roemerine 11.9335 µM -0.568886832645847 0.288322941015362 no 2401 0.28471647087168 3461 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2405 ticlatone 3.52 µM -0.57021022733874 0.287882931794183 no 2402 0.284267560116329 3259 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3307 9126885 69.2785 µM -0.570498879758799 0.287787001263599 no 2403 0.284169690849943 3396 24824909
SGTC_253 dyclonine 31.25 µM -0.571299548124132 0.287520986801728 no 2404 0.283898303990627 3510 3180 An oral anasthetic.
SGTC_775 4577-0580 57.3 µM -0.571391264162411 0.287490522442032 no 2405 0.28386722472355 3551 2006902
SGTC_2025 5147754 141 µM -0.572242204371856 0.287207947311499 no 2406 0.283578949366385 3452 315777 YLR208W SEC13
SGTC_351 caspofungin 25 nM -0.574603828542074 0.2864244027771 no 2407 0.28277963109632 3469 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2263 7948595 193.29 µM -0.575293301512952 0.286195839484423 no 2408 0.282546475500773 3463 2971371
SGTC_284 0988-0104 32.6 µM -0.577568022210194 0.285442374660595 no 2409 0.281777900830228 3463 4666532
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.578526468961641 0.285125187586713 no 2410 0.281454366205723 3558 688751
SGTC_54 0159-0055 9 µM -0.578898536635592 0.285002101297786 no 2411 0.281328818835484 3584 3319099
SGTC_1438 4092-1045 4 µM -0.579561546004334 0.284782829393858 no 2412 0.281105165586881 3468 1351342
SGTC_1799 st045822 46.1415 µM -0.580303658123278 0.284537491983297 no 2413 0.280854930486985 3489 3674992
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.580570157955497 0.284449413522875 no 2414 0.280765094865111 3398 23665772 A membrane-active detergent.
SGTC_2886 9058944 51.95 µM -0.580579137763843 0.284446445914114 no 2415 0.280762068063326 3330 4949929
SGTC_875 0709-0210 25.7 µM -0.58136716290167 0.28418608034784 no 2416 0.280496511851447 3513 6251364
SGTC_231 b-estradiol 524 µM -0.582033846655767 0.283965895317302 no 2417 0.280271941389952 3406 450 A steroid.
SGTC_1996 st072960 66.8 µM -0.582928529595045 0.283670537551578 no 2418 0.279970706997186 3524 1719405
SGTC_2828 7998861 71.43 µM -0.583243551699598 0.283566575720129 no 2419 0.279864678318812 3442 2988188
SGTC_1219 1469-0211 33.1 µM -0.583503278137993 0.283480875987655 no 2420 0.279777275449532 3481 6822282
SGTC_837 0091-0265 12.5 µM -0.586580226314415 0.282466547271749 no 2421 0.278742833051824 3437 759367
SGTC_1247 0448-0043 5.84 µM -0.586758447761378 0.282407849348922 no 2422 0.278682973688186 3485 3089013 YGL099W LSG1
SGTC_2756 carbadox 75.1 µM -0.589201162882296 0.281603923525069 no 2423 0.277863168585378 3460 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1989 st071868 50.2 µM -0.59034933296644 0.281226429142244 no 2424 0.277478235801288 3504 16414057
SGTC_225 nsc-122657 1.016 µM -0.591465107191797 0.280859820104101 no 2425 0.27710441386528 3461 275685
SGTC_556 4058-0063 51.5 µM -0.59150890763556 0.280845433341806 no 2426 0.277089744270408 3497 6615692
SGTC_1139 k015-0024 46.9 µM -0.593169541257413 0.280300242014962 no 2427 0.276533847272109 3516 2766652
SGTC_192 3455-0609 60.9 µM -0.593221138401681 0.280283310721596 no 2428 0.276516583893085 3555 3769639
SGTC_1757 st041620 31.8375 µM -0.593443910974968 0.28021021492499 no 2429 0.276442054683512 3495 5289815
SGTC_1826 st055655 41.6 µM -0.593474074872251 0.280200318303019 no 2430 0.276431964021593 3482 676168
SGTC_2965 9082772 38.63 µM -0.595568755759323 0.279513478633121 no 2431 0.275731677203324 3571 16459634
SGTC_550 4123-0385 25.7 µM -0.595652456113786 0.279486050529207 no 2432 0.275703712903732 3484 5731123
SGTC_1369 1866-0067 208 µM -0.596303002979335 0.279272914793393 no 2433 0.275486412646908 3539 3531355
SGTC_1351 1496-0003 46.5 µM -0.596395680200986 0.279242557802014 no 2434 0.275455462804131 3521 3891978
SGTC_383 2324-0395 7.37 µM -0.597284143679015 0.278951617558098 no 2435 0.2751588445279 3519 3146421
SGTC_1856 st057054 55.7 µM -0.597787282344056 0.278786922932913 no 2436 0.274990938778922 3603 1266018
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.598635765013907 0.278509292559539 no 2437 0.274707900374243 3493 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_398 bronopol 33.3 µM -0.600240205434234 0.27798467514523 no 2438 0.274173081158114 3460 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_470 aa-861 153 µM -0.60148033536827 0.277579510087134 no 2439 0.273760052767833 3476 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2887 9044784 58.44 µM -0.602206615880771 0.277342359737991 no 2440 0.273518306187381 3524 6465546
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.60231968960855 0.277305447004122 no 2441 0.273480678464926 3474 115019
SGTC_3306 9127676 59.7925 µM -0.603362019829748 0.276965293203895 no 2442 0.273133941324338 3482 41905287
SGTC_281 1672-3440 14.9 µM -0.604154110344106 0.276706939242997 no 2443 0.272870593622119 3518 6833000
SGTC_1432 4049-0298 68.4 µM -0.605886810516683 0.276142201253157 no 2444 0.272294959201461 3539 741646
SGTC_126 0417-1624 672.48 µM -0.606629410307774 0.275900339439768 no 2445 0.27204843892083 3618 41912 YDL195W SEC31
SGTC_1973 st070275 50.2 µM -0.606739163318261 0.275864602147177 no 2446 0.272012013713773 3497 17118334
SGTC_329 k048-0121 21.3 µM -0.607096125159729 0.275748385531762 no 2447 0.271893560763287 3522 6832902
SGTC_1861 st057647 17.4 µM -0.607107343017284 0.275744733706653 no 2448 0.271889838685184 3578 688668
SGTC_853 0419-0306 21 µM -0.608209637991084 0.275386012128421 no 2449 0.271524221574718 3451 762713
SGTC_2396 5342950 42.78 µM -0.608260811035961 0.27536936438345 no 2450 0.27150725408152 3504 1886677
SGTC_990 3985-0011 41.3 µM -0.608754612590732 0.275208745057632 no 2451 0.271343550990206 3465 5399565 YGL099W LSG1
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.609883008540624 0.274841883793894 no 2452 0.27096965445442 3461 803109
SGTC_2914 7968218 45.32 µM -0.61080325877035 0.274542872903859 no 2453 0.270664917885131 3499 2977111
SGTC_867 0518-0118 155 µM -0.612939084668513 0.273849512073389 no 2454 0.269958309309799 3567 6848158
SGTC_607 4491-0986 66.8 µM -0.613971224832634 0.273514755286178 no 2455 0.269617171141641 3572 698981 YDR232W HEM1
SGTC_917 harmaline 728.087 nM -0.614053747673179 0.273487999179017 no 2456 0.269589905403248 3500 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2681 menadione 3.18 µM -0.616131423790552 0.272814788392777 no 2457 0.268903891971521 3566 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1034 k072-0165 12.7 µM -0.620170949204398 0.271508254475231 no 2458 0.267572622715142 3567 5835461
SGTC_1811 st050069 61.5 µM -0.621742998053496 0.271000638718716 no 2459 0.267055436667936 3539 3877702
SGTC_2796 7949634 45.45 µM -0.623118890079194 0.270556751006786 no 2460 0.266603198562021 3540 2971588
SGTC_1832 st054113 55 µM -0.623346435938778 0.270483375603479 no 2461 0.266528444482372 3561 1251267
SGTC_1739 st037196 92.5 µM -0.625222856145018 0.269878676515927 no 2462 0.265912401453819 3568 612214
SGTC_3287 9117173 37.0625 µM -0.625251266918703 0.269869526004309 no 2463 0.265903079528343 3507 2789709
SGTC_1911 st060208 74.3 µM -0.6253405552454 0.269840769126641 no 2464 0.265873784004408 3529 688783
SGTC_2429 5902844 64.44 µM -0.625360986434735 0.26983418911809 no 2465 0.265867080755665 3542 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1378 2093-0007 380 nM -0.627100013432067 0.269274417803324 no 2466 0.265296839167715 3554 3618014
SGTC_1929 genistein trimethyl ether 50.5 µM -0.627129315580964 0.269264990795161 no 2467 0.265287236068128 3596 136420
SGTC_1222 0366-0074 1.18 µM -0.627795224692623 0.269050800949166 no 2468 0.26506904738713 3588 286520
SGTC_961 1252-1571 372 µM -0.631438146109764 0.267880569800758 no 2469 0.26387704032331 3578 6813498
SGTC_3176 9106582 49.47 µM -0.631649424994985 0.267812778522521 no 2470 0.263807991303747 3484 17018027
SGTC_2339 9000433 200 µM -0.632039540647528 0.267687628111846 no 2471 0.263680520037314 3488 2988954
SGTC_1669 st015249 58.4 µM -0.632589633328851 0.267511206629967 no 2472 0.263500829278597 3632 722793
SGTC_948 3448-0295 75.3 µM -0.633215371817979 0.267310595910594 no 2473 0.263296504413542 3592 678569
SGTC_3265 9137266 49.47 µM -0.63401159908385 0.267055436564329 no 2474 0.263036626207882 3526 17224265
SGTC_1357 1503-1303 39.5 µM -0.6340932145369 0.267029288990591 no 2475 0.263009995396742 3572 292895
SGTC_2284 7945075 39.21 µM -0.634476883088185 0.266906388396661 no 2476 0.262884824280173 3596 1245402
SGTC_1558 st069300 45.6 µM -0.634482797317537 0.266904494114511 no 2477 0.262882895012793 3534 24208000
SGTC_710 3448-4187 58 µM -0.635006239256391 0.266736866594756 no 2478 0.262712172881291 3587 3946412
SGTC_1475 4092-1048 11.7 µM -0.637030335555026 0.26608916926772 no 2479 0.26205254204351 3575 2881759
SGTC_1676 st018489 23.4 µM -0.637129668837873 0.266057403794209 no 2480 0.262020192280615 3540 3696235
SGTC_1168 k815-0004 80.5 µM -0.637400827922821 0.265970700474331 no 2481 0.261931894617272 3549 642433
SGTC_3237 9133362 49.47 µM -0.638085192541812 0.265751938047754 no 2482 0.261709112503405 3542 43845137
SGTC_3210 9128157 49.47 µM -0.63845493996111 0.265633783400081 no 2483 0.261588788606602 3498 17590849
SGTC_2393 9031399 185.94 µM -0.63852294623716 0.265612054553376 no 2484 0.261566660969005 3623 1526623 YDL150W RPC53
SGTC_1334 1486-0610 236 µM -0.639543813589782 0.265285983169104 no 2485 0.261234610324348 3576 3742339
SGTC_468 gf-109203x 121 µM -0.639861138908788 0.265184668903615 no 2486 0.261131440199233 3496 2396 A protein kinase C inhibitor.
SGTC_847 0342-0274 5.54 µM -0.640224015401957 0.265068835341178 no 2487 0.261013485959493 3570 18097
SGTC_175 3793-3120 23.7 µM -0.640663882827561 0.264928460023547 no 2488 0.260870542292987 3558 5322297
SGTC_842 0271-0008 11.1 µM -0.640844753659882 0.264870749502842 no 2489 0.260811776404386 3623 1221709
SGTC_2324 6149169 200 µM -0.640889402549692 0.26485650434915 no 2490 0.260797270792465 3498 2888231
SGTC_2328 6201408 200 µM -0.641513296748449 0.264657492695576 no 2491 0.260594622348913 3557 2890418
SGTC_3021 9087658 49.47 µM -0.642851834473899 0.264230778675766 no 2492 0.26016012265225 3589 25237042
SGTC_3129 9127257 49.47 µM -0.643148216245328 0.264136342182887 no 2493 0.260063965357272 3467 837894
SGTC_1559 coumarin 343 70.1 µM -0.644681340644477 0.263648115498388 no 2494 0.259566855366199 3622 108770 A hepatotoxic, DNA x-linker.
SGTC_929 2805-0021 398 µM -0.644819079122636 0.263604274939988 no 2495 0.259522218199272 3584 3098024
SGTC_627 1391-0720 175 µM -0.645568924404655 0.263365673151804 no 2496 0.259279283981539 3536 997839
SGTC_2129 girgensonine 121.053 µM -0.647910420631938 0.262621316315432 no 2497 0.258521445218549 3605 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_334 1502-1024 68.5 µM -0.648497969485384 0.262434704845549 no 2498 0.258331461853383 3608 3296216
SGTC_706 4262-0057 46.9 µM -0.650389589523444 0.261834368637972 no 2499 0.257720300091756 3572 883298
SGTC_3342 9147791 14.508 µM -0.650416636287712 0.261825790020468 no 2500 0.257711567023756 3575 1838168
SGTC_1243 0416-0003 5.65 µM -0.650638796526855 0.261755331309169 no 2501 0.257639840024876 3566 2141977
SGTC_1493 4348-0038 111 µM -0.651061986406791 0.261621142430444 no 2502 0.257503236969594 3630 800424
SGTC_1360 1598-0022 39.8 µM -0.651123791931829 0.261601547530094 no 2503 0.257483289680403 3614 761525
SGTC_2444 5485484 36.41 µM -0.652836334865997 0.261058900556345 no 2504 0.256930898179377 3647 6790631
SGTC_3061 glucosamine 200 µM -0.653151125416875 0.260959217066965 no 2505 0.256829427634466 3557 91431 and experimental redox chemotherapeutic
SGTC_814 3342-0569 96 µM -0.653618282045555 0.26081132049487 no 2506 0.256678881395779 3645 4346283
SGTC_2326 6164455 177.58 µM -0.654811965561451 0.260433609583486 no 2507 0.256294412874837 3583 2888790
SGTC_3233 9132340 49.47 µM -0.656134367287587 0.260015498229262 no 2508 0.255868836791578 3549 17682950
SGTC_2443 5493264 126.67 µM -0.656377336420862 0.259938714940274 no 2509 0.255790684451053 3588 5340055
SGTC_2813 7971799 71.43 µM -0.656629473650085 0.259859046709612 no 2510 0.2557095963197 3624 2234054
SGTC_2978 9011784 42.97 µM -0.656785400049736 0.259809784683583 no 2511 0.255659456613345 3657 2994934
SGTC_1221 2958-7315 257 µM -0.657002906148013 0.259741075754529 no 2512 0.25558952391064 3609 4562705
SGTC_2958 9077254 16.72 µM -0.657502328571809 0.2595833465683 no 2513 0.255428987104554 3638 16457351
SGTC_2772 vinpocetine 57.06 µM -0.658175970351769 0.259370673234707 no 2514 0.255212531867529 3645 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_694 1315-0438 43.2 µM -0.659380682781688 0.258990561818056 no 2515 0.254825671755189 3554 6793154
SGTC_2281 7943571 200 µM -0.660646520566402 0.258591474740035 no 2516 0.254419513890108 3671 1244024
SGTC_1971 st069429 63.5 µM -0.661730581894804 0.258249950545496 no 2517 0.254071950854665 3603 1246522 YGL099W LSG1
SGTC_2287 7945887 168.79 µM -0.667045293461424 0.256578985412286 no 2518 0.252371601239274 3639 1245853
SGTC_2879 9041815 71.43 µM -0.667793409705095 0.256344227808146 no 2519 0.252132736957893 3575 4942971
SGTC_1017 4239-0030 168 µM -0.668506013975585 0.256120717946895 no 2520 0.251905322153437 3597 1149593
SGTC_1922 5578187 25 µM -0.668955384229003 0.255979824272264 no 2521 0.251761969420924 3654 1350412
SGTC_2061 5245884 80.95 µM -0.669784975621944 0.25571982392209 no 2522 0.251497436286866 3621 573863
SGTC_2807 7945238 51.95 µM -0.670566973991399 0.255474865897733 no 2523 0.251248213757498 3645 17148797
SGTC_3286 9117135 37.221 µM -0.671116861143871 0.255302689277249 no 2524 0.251073043202283 3591 3438150
SGTC_13 0199-0087 65 µM -0.672283300278998 0.254937663339096 no 2525 0.250701679523314 3656 4589825
SGTC_3075 9116269 49.47 µM -0.672782813896626 0.254781428905494 no 2526 0.250542736472847 3646 17015205 YNL244C SUI1
SGTC_1619 st003326 88.7 µM -0.673298458530051 0.254620201718664 no 2527 0.250378716624821 3602 2849032
SGTC_443 clozapine 122 µM -0.673391756656462 0.254591035798754 no 2528 0.25034904578688 3559 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1217 1183-1422 255 µM -0.673601371818484 0.254525514402678 no 2529 0.250282390394952 3655 2849664
SGTC_1896 st058441 89 µM -0.674136289944992 0.25435835002515 no 2530 0.250112334774904 3590 688759
SGTC_1102 cgs 12066b 26.1 µM -0.674751200220033 0.254166258854499 no 2531 0.2499169246336 3601 6438352 A 5-HT1B full agonist.
SGTC_1761 st044296 37 µM -0.675107379534439 0.254055027182001 no 2532 0.249803772753613 3643 1826700
SGTC_356 1634-0012 32.5 µM -0.675400183841869 0.253963606097084 no 2533 0.249710774369008 3640 735457
SGTC_1086 cerivastatin 2.18 µM -0.677820538848608 0.253208570228381 no 2534 0.248942743405577 3598 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2098 5376439 882.5 nM -0.677951794304003 0.253167658526603 no 2535 0.248901129178556 3689 2844116
SGTC_131 0141-0277 33.849 µM -0.679012904184574 0.252837043319485 no 2536 0.24856484284212 3607 1547771
SGTC_1440 4100-1550 40 µM -0.679878519396709 0.252567507771466 no 2537 0.248290691939471 3654 742806
SGTC_115 0527-0192 112.043 µM -0.6806271580639 0.252334518549412 no 2538 0.248053719003889 3672 4233931
SGTC_3271 9137798 49.47 µM -0.680774660858466 0.252288626509138 no 2539 0.248007042928735 3582 6498326
SGTC_3143 9086658 49.47 µM -0.681120897246417 0.252180920455687 no 2540 0.247897497617032 3696 25236626
SGTC_2488 5268135 45.7 µM -0.68158817484371 0.252035599767184 no 2541 0.247749697179642 3647 1270356 YLR208W SEC13
SGTC_282 k297-0036 65.7 µM -0.684903732291723 0.251005750454691 no 2542 0.246702335333672 3654 5061378
SGTC_491 tetrandrine 80.3 µM -0.685111913432133 0.250941161435578 no 2543 0.246636651543165 3629 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2682 pyrogallin 40.03 µM -0.687110754343066 0.250321461102799 no 2544 0.246006468863892 3687 822798 An ATP competetive kinase inhibitor.
SGTC_1618 st003135 44.5 µM -0.687158695671122 0.250306607829876 no 2545 0.24599136482276 3601 1270615
SGTC_533 1222-0222 6.71 µM -0.687662535049608 0.250150535625271 no 2546 0.245832659001469 3723 3982874
SGTC_3083 9117465 49.47 µM -0.687960079945764 0.25005839064239 no 2547 0.245738960294212 3641 16420915
SGTC_1264 0783-0040 158 µM -0.688339309786244 0.249940975221936 no 2548 0.245619566297261 3598 2855798
SGTC_1373 2887-0003 58.5 µM -0.688348128053068 0.249938245298367 no 2549 0.245616790388224 3649 776948
SGTC_2581 avocatin a 64 µM -0.688896409153629 0.249768541724757 no 2550 0.245444229653741 3668 6710728 A skin care supplement.
SGTC_666 0272-0154 136 µM -0.6907700232168 0.249189084114567 no 2551 0.24485503833186 3697 6870312
SGTC_519 k048-0011 62.8 µM -0.691148192020228 0.249072213618728 no 2552 0.244736208808958 3675 6836379
SGTC_370 0180-0345 38.7 µM -0.69197150936308 0.24881787388002 no 2553 0.24447761056968 3599 3989527
SGTC_3226 9131256 49.47 µM -0.693330024110542 0.248398503095805 no 2554 0.244051232615648 3570 17178073
SGTC_1412 3909-8563 178 µM -0.695673999090003 0.247675809416557 no 2555 0.243316506129271 3733 23767530
SGTC_2024 5144227 134 µM -0.697171092319808 0.247214814388433 no 2556 0.24284786377914 3685 3475211
SGTC_1071 trifluoperazine 6.31 µM -0.6988733234024 0.246691209887827 no 2557 0.242315600115626 3734 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_636 0kpi-0074 126 µM -0.699340139565157 0.246547721558736 no 2558 0.242169743817799 3678 616434
SGTC_2242 6630449 61.2675 µM -0.701084043152181 0.24601208227695 no 2559 0.24162528394942 3700 691249 YDR170C SEC7
SGTC_2511 berberine 10.47 µM -0.701741757835732 0.245810227736015 no 2560 0.241420113179819 3678 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1425 4048-4433 7.33 µM -0.706313217632278 0.24440969332185 no 2561 0.23999668772319 3739 23734946
SGTC_324 1315-0088 19.6 µM -0.706402572465336 0.244382361056272 no 2562 0.239968910786522 3627 6787421
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.706891883028234 0.244232717711417 no 2563 0.239816834284745 3647 4620898
SGTC_1347 1493-0251 600 nM -0.708952825784412 0.243602972719095 no 2564 0.239176875897506 3722 3986378
SGTC_1642 st009582 77.7 µM -0.709461182299904 0.243447773416398 no 2565 0.239019166011967 3690 6739311
SGTC_2131 toluylene red 5.2905 µM -0.710054188487439 0.243266798416429 no 2566 0.238835266715353 3694 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1164 k060-0068 93.7 µM -0.711937775586434 0.242692443588437 no 2567 0.238251654341131 3714 5963676
SGTC_3205 9113483 49.47 µM -0.713828984257291 0.242116504128286 no 2568 0.237666467344295 3727 17018033
SGTC_1790 st045711 43.5 µM -0.715417183352615 0.241633414788002 no 2569 0.237175648872485 3713 585119
SGTC_3153 9100258 49.47 µM -0.715862010348396 0.241498203720598 no 2570 0.23703827902851 3656 25236848
SGTC_1477 0139-0234 16 µM -0.717047987456751 0.241137911153073 no 2571 0.236672243707821 3704 620880
SGTC_1489 4065-0444 182 µM -0.718436261912959 0.240716533391758 no 2572 0.236244167427125 3675 2877968
SGTC_1969 st069479 40.1 µM -0.718695840752977 0.240637788890353 no 2573 0.236164173289529 3667 3895485
SGTC_143 4032-1194 15.74 µM -0.71879988838122 0.240606229474328 no 2574 0.236132113230822 3725 1806963
SGTC_2260 7964312 200 µM -0.721140389097636 0.239896911549292 no 2575 0.235411571723121 3730 231951
SGTC_3327 9140648 26.9345 µM -0.722226346170894 0.239568186493504 no 2576 0.235077663900732 3695 8029710
SGTC_1420 4'-methoxyflavone 42 µM -0.723365898652472 0.239223502389868 no 2577 0.234727558159043 3693 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2730 imipramine 71.33 µM -0.723649343993862 0.23913780986781 no 2578 0.234640519782473 3715 3696 A tricyclic antidepressant.
SGTC_1716 st033144 30.6155 µM -0.724199798531986 0.238971441811485 no 2579 0.234471541121888 3716 674617
SGTC_552 k242-0005 476 µM -0.724718475377117 0.238814736096162 no 2580 0.23431237921267 3742 4088318
SGTC_699 0375-0592 111 µM -0.724749406395318 0.238805392810335 no 2581 0.234302889566477 3740 762578
SGTC_2545 solidagenone 89.61 µM -0.726280163652145 0.238343249186267 no 2582 0.233833518613674 3544 6708572 An anti ulcer agent
SGTC_2186 6124449 200 µM -0.726679116092357 0.238222883872121 no 2583 0.233711274822098 3678 3834182 YLR033W RSC58
SGTC_896 0964-0007 44.5 µM -0.728514049384027 0.237669707282551 no 2584 0.233149485777646 3690 6756758
SGTC_2434 5670830 169.91 µM -0.728828005248376 0.237575129794275 no 2585 0.233053439210483 3739 1549830
SGTC_2674 ligustilide 100 µM -0.729914340798914 0.237248036578176 no 2586 0.232721272919183 3714 5319022 A signalling regulator.
SGTC_3011 9081274 71.4286 µM -0.730039355054703 0.237210410941013 no 2587 0.232683064490236 3721 6625322
SGTC_633 0437-0093 97.7 µM -0.730801144031443 0.236981205582355 no 2588 0.232450312336634 3695 2831118
SGTC_485 niflumic acid 177 µM -0.732115230492242 0.236586112458559 no 2589 0.232049119223586 3746 4488 A COX2 inhibitor.
SGTC_1952 st077036 64.1 µM -0.733165752116893 0.236270523573605 no 2590 0.231728670425921 3732 2937007
SGTC_2372 9071633 200 µM -0.734836381788175 0.235769124847714 no 2591 0.231219573453977 3778 21321366
SGTC_2432 5630864 12.22 µM -0.736110147382707 0.235387229725992 no 2592 0.230831833923197 3724 5714970
SGTC_2113 5491891 107.031 µM -0.73721928060247 0.235054972274578 no 2593 0.230494505131042 3749 789979
SGTC_1520 flindersine 88 µM -0.739043064100285 0.234509194341838 no 2594 0.229940424035915 3816 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1632 st005650 90 µM -0.739981063549866 0.234228765723087 no 2595 0.229655742321086 3768 2759605
SGTC_798 1287-0182 476 µM -0.740037209918304 0.234211985837934 no 2596 0.229638708229753 3752 1649755
SGTC_336 4111-0029 111 µM -0.741207286073842 0.233862448753063 no 2597 0.229283883162472 3685 3131175
SGTC_3322 9139058 2.11 µM -0.741543704692733 0.233762003880511 no 2598 0.229181921291832 3839 4908926 YPR165W RHO1
SGTC_1981 st071826 47 µM -0.742920846074871 0.233351078674627 no 2599 0.228764802012073 3734 11838600
SGTC_3020 9089140 49.47 µM -0.743968706247474 0.233038676389885 no 2600 0.228447703714871 3783 17217859
SGTC_2663 amphotericin b 100 µM -0.745030081686598 0.232722481653013 no 2601 0.228126767401698 3744 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1377 2944-0135 198 µM -0.745191548564845 0.232674399901802 no 2602 0.228077965638843 3812 1894137
SGTC_1835 st008666 49.2 µM -0.745264923867205 0.232652551963571 no 2603 0.22805579062165 3682 690455
SGTC_3071 9117417 49.47 µM -0.745431286321047 0.232603020764927 no 2604 0.228005518110367 3680 45595590 YGL055W OLE1
SGTC_874 0599-0792 117 µM -0.747490052975537 0.2319905482704 no 2605 0.22738390244899 3756 765305
SGTC_3157 9099274 49.47 µM -0.74766998409646 0.231937062390073 no 2606 0.227329620179751 3711 17217662
SGTC_1002 4049-0206 172 µM -0.747677081370125 0.231934952812828 no 2607 0.227327479198333 3777 4662749
SGTC_1759 st043059 70 µM -0.748748498575584 0.231616609825289 no 2608 0.227004403130903 3755 669426
SGTC_1165 k072-0275 30.3 µM -0.749697308140055 0.231334899858235 no 2609 0.226718514572293 3754 6153523 YGL055W OLE1
SGTC_862 0452-0056 10.2 µM -0.7498908783407 0.231277450630321 no 2610 0.226660214337791 3701 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2185 6113692 200 µM -0.750748845918606 0.231022912358607 no 2611 0.226401910174911 3731 874150
SGTC_2 0422-0095 29 µM -0.750754828600281 0.23102113799052 no 2612 0.226400109581624 3628 6790840
SGTC_2490 carminic acid 95.39 µM -0.750991403699422 0.230950979682682 no 2613 0.226328914627351 3684 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1141 3253-0389 52.6 µM -0.752526466336779 0.23049603324085 no 2614 0.225867259958672 3716 5402031
SGTC_3209 9113616 49.47 µM -0.753533843194206 0.230197749439546 no 2615 0.225564591109155 3748 16649353
SGTC_2088 5278280 127.392 µM -0.755239108649934 0.229693313617799 no 2616 0.225052763428502 3822 791502
SGTC_2460 5552655 174.22 µM -0.756346706266821 0.229366006285457 no 2617 0.224720675883112 3744 5401989
SGTC_2141 5621638 7.665 µM -0.756794021400866 0.22923389387214 no 2618 0.224586637600592 3802 2856238
SGTC_107 0358-0022 2.6945 µM -0.757325870044885 0.229076870427221 no 2619 0.224427327833724 3785 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2739 tacrine 100.86 µM -0.759174644481299 0.228531506361668 no 2620 0.223874045781501 3779 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_540 1187-0821 17.3 µM -0.76009815400046 0.228259356624568 no 2621 0.223597958009537 3736 847520
SGTC_977 1348-1378 135 µM -0.760468359102033 0.228150311769215 no 2622 0.223487337741244 3760 X977
SGTC_2603 homopterocarpin 100 µM -0.760752451908911 0.228066651376544 no 2623 0.223402469636669 3821 101795 A weak amylase inhibitor.
SGTC_1946 st076057 65.1 µM -0.761985687066291 0.227703685131952 no 2624 0.223034273338516 3658 953009
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.762847715818618 0.227450165702599 no 2625 0.222777110250851 3838 5282309
SGTC_890 0929-0006 47.2 µM -0.763289441207681 0.227320317552377 no 2626 0.222645398868295 3760 1378169
SGTC_1863 st057641 20.1 µM -0.765856926683547 0.226566415386188 no 2627 0.221880718780284 3796 3921635
SGTC_1001 4048-4355 44.4 µM -0.766452763524584 0.226391659170485 no 2628 0.221703474001128 3772 21824233
SGTC_3303 9125618 40.5795 µM -0.766693496315927 0.226321074943221 no 2629 0.22163188568681 3817 22695467
SGTC_2004 4023728 41.89 µM -0.768858190651251 0.225686932948337 no 2630 0.220988749848135 3783 360084 YDR527W RBA50
SGTC_1358 1509-0022 2.48 µM -0.769660258247918 0.225452224662619 no 2631 0.220750725143781 3814 3258434
SGTC_2336 9001819 198.65 µM -0.769934178553778 0.225372099285549 no 2632 0.220669469133079 3808 2989602
SGTC_2215 7188065 200 µM -0.769946686606891 0.225368440896599 no 2633 0.220665759139975 3775 940217
SGTC_2187 6125751 200 µM -0.770722399766121 0.225141623943686 no 2634 0.220435745959414 3801 874498
SGTC_1903 st060211 78.3 µM -0.771873852754457 0.224805180005967 no 2635 0.220094572530699 3828 688960
SGTC_1035 k081-0041 55.2 µM -0.776026748697353 0.223594113148465 no 2636 0.218866596202187 3778 731709
SGTC_75 0159-0059 199.013 µM -0.777064063644945 0.223292191688759 no 2637 0.218560487297133 3834 5377270
SGTC_382 3229-0966 23.2 µM -0.777809409144402 0.223075394349954 no 2638 0.21834069007876 3802 5722370
SGTC_1767 st044992 70.3 µM -0.777870754774324 0.223057556194268 no 2639 0.218322605351091 3825 9600693
SGTC_866 0495-0101 262 µM -0.777975589222399 0.223027074188245 no 2640 0.218291702091809 3774 635694
SGTC_916 4466-0038 42 nM -0.779262435424496 0.222653099925401 no 2641 0.217912568982311 3883 5722064 YGL116W CDC20
SGTC_1581 himbacine 57.9 µM -0.780693501109972 0.222237633708755 no 2642 0.217491391929535 3794 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2709 st078560 56 µM -0.781648081154768 0.221960746675947 no 2643 0.217210710857546 3782 17250903
SGTC_3230 9131665 49.47 µM -0.781974529879638 0.221866101650155 no 2644 0.217114771154781 3729 15943720
SGTC_2532 xanthone 78.9 µM -0.782879232252153 0.221603928021426 no 2645 0.216849017024011 3748 7020 An insecticide.
SGTC_2520 obtusaquinone 4.71 µM -0.784287422821607 0.221196201070634 no 2646 0.216435738856845 3825 5967872
SGTC_1324 1418-0026 34.4 µM -0.784909622693339 0.221016186350559 no 2647 0.216253279870037 3866 1372513
SGTC_2570 licareol 100 µM -0.78558558995958 0.220820710721575 no 2648 0.216055154658956 3834 443158
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.78645949236952 0.22056814315903 no 2649 0.215799170785716 3802 77254
SGTC_3313 9133968 57.047 µM -0.78796247167713 0.220134152687002 no 2650 0.21535932882238 3794 1494643
SGTC_2097 5376186 200 µM -0.788147650165633 0.220080715668324 no 2651 0.215305172959461 3752 742755
SGTC_3150 9097574 49.47 µM -0.788614369840497 0.219946067230649 no 2652 0.215168714810803 3796 17217476
SGTC_2995 9067767 71.4286 µM -0.78889196569217 0.219866003364164 no 2653 0.215087575953818 3833 11673567
SGTC_1796 st049173 110.4 µM -0.79039119720604 0.219433886011453 no 2654 0.214649670753341 3758 94134
SGTC_2268 7933382 153.85 µM -0.792002778181556 0.218969931253758 no 2655 0.21417952816028 3849 935025 YOR257W CDC31
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.794207724875621 0.218336068648524 no 2656 0.213537256067648 3874 65057 A dermal irritant. YDR527W RBA50
SGTC_2278 7948257 134.34 µM -0.796082601303473 0.217797924814577 no 2657 0.212992013088379 3811 1247028
SGTC_3048 9093155 49.47 µM -0.797314161919962 0.217444847985738 no 2658 0.212634298751535 3749 25236002
SGTC_1961 st076550 68.7 µM -0.79768946589915 0.217337317598035 no 2659 0.212525359194933 3836 1579337
SGTC_2094 5332512 191.667 µM -0.799892922542924 0.216706612918365 no 2660 0.211886419346774 3876 755774
SGTC_611 3453-1652 23.7 µM -0.80004369465475 0.216663495508866 no 2661 0.211842740832251 3793 1560575
SGTC_2273 7815444 169.05 µM -0.800389803462088 0.216564534999779 no 2662 0.211742493421296 3754 2824616
SGTC_1590 st077108 57.8 µM -0.801156396887482 0.216345441343371 no 2663 0.211520555156739 3793 5489485
SGTC_2669 eugenol 100 µM -0.801622399324206 0.216212319809036 no 2664 0.211385708286111 3787 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_503 tyrphostin 8 294 µM -0.803013007840607 0.215815350856638 no 2665 0.210983608090147 3787 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_690 glyoxal 20.3 µM -0.803568190738549 0.215656984075534 no 2666 0.210823199993166 3702 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1048 3161-0300 24.5 µM -0.804168204340569 0.215485905049571 no 2667 0.210649919479612 3838 2165101
SGTC_1850 st056238 17 µM -0.804308582442726 0.215445891074529 no 2668 0.21060939114775 3848 5393177
SGTC_711 k292-0785 179 µM -0.804638115532535 0.215351976488993 no 2669 0.210514270167875 3813 4146315
SGTC_2662 daunorubicin 22.37 µM -0.805730650218716 0.21504078185 no 2670 0.210199086298787 3724 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.805920776901325 0.214986653363651 no 2671 0.210144265233316 3844 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.806100497137957 0.214935494835966 no 2672 0.210092452481465 3653 88881 An O-methylated flavonoid and antioxidant.
SGTC_1690 st023502 41.2 µM -0.807016200983992 0.214674943626725 no 2673 0.209828574641256 3798 24207482
SGTC_2502 avocadyne acetate 18.59 µM -0.807935810977583 0.214413465802484 no 2674 0.209563767348429 3808 3952079
SGTC_3076 9116187 49.47 µM -0.808173675114094 0.214345862729465 no 2675 0.209495304934852 3838 27241210
SGTC_1572 epiandrosterone 68.9 µM -0.808954291171307 0.214124091920279 no 2676 0.209270719312573 3759 441302 A steroid.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.809916774271347 0.213850837092787 no 2677 0.208994005163576 3851 641818 YHR062C RPP1
SGTC_999 SEC7.066 22.7 µM -0.810623379620496 0.213650356841569 no 2678 0.208790993188867 3841 740511 YDR170C SEC7
SGTC_2196 6573537 42.6665 µM -0.811444015663958 0.213417660928081 no 2679 0.208555365415078 3857 2903087
SGTC_38 0929-0051 58.268 µM -0.811469852040745 0.213410337279282 no 2680 0.208547949608539 3869 1379719
SGTC_3026 9090633 49.47 µM -0.812487285620468 0.213122049316226 no 2681 0.208256039621479 3863 25236842
SGTC_2620 irigenin 100 µM -0.812931895711467 0.212996141208779 no 2682 0.20812855309011 3882 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_185 k048-0037 25.491 µM -0.813748705385398 0.212764943901305 no 2683 0.207894462928865 3874 6827589
SGTC_2611 pyromycin 23.93 µM -0.814242646855741 0.212625205287623 no 2684 0.207752979300176 3863 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1389 3405-0187 19 µM -0.81684107904704 0.211890978399628 no 2685 0.207009626587545 3821 799890
SGTC_570 0987-0065 62.6 µM -0.819020841772419 0.211276198559151 no 2686 0.206387261311084 3666 3104428
SGTC_208 k072-0098 12.366 µM -0.819758124863706 0.211068492125424 no 2687 0.206177003630667 3834 5948901
SGTC_2219 9098279 200 µM -0.819887522569753 0.211032050722115 no 2688 0.206140115221399 3816 902349
SGTC_1931 st074438 57.1 µM -0.820913152938213 0.210743339851671 no 2689 0.205847869256998 3839 2787313
SGTC_3086 9117350 49.47 µM -0.822731318539628 0.210232103263934 no 2690 0.205330400635258 3770 2679265
SGTC_2212 7123476 200 µM -0.82480961268632 0.209648616087353 no 2691 0.204739844182097 3823 1085715
SGTC_2968 9090663 33.37 µM -0.826507287939442 0.209172696268514 no 2692 0.204258192796347 3856 25236811
SGTC_2678 equilin 100 µM -0.826992320925379 0.20903684087973 no 2693 0.204120706981781 3877 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2473 5854593 8.94 µM -0.82720315568814 0.208977803291577 no 2694 0.20406096166284 3787 2872951
SGTC_2716 st080858 38.6235 µM -0.82884208040423 0.208519209412678 no 2695 0.203596886583309 3860 5296050
SGTC_522 1273-0010 11.6 µM -0.829268646748865 0.208399947621892 no 2696 0.203476204101737 4001 5705015
SGTC_2234 tolnaftate 200 µM -0.831737430457614 0.207710501959217 no 2697 0.202778584045744 3871 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3310 9130229 44.1445 µM -0.833344434596649 0.207262446333448 no 2698 0.202325251400158 3960 7761258
SGTC_1731 st035964 63 µM -0.833627204748231 0.207183665166238 no 2699 0.202245545266481 3873 6739575
SGTC_2625 euphol 100 µM -0.833870987989912 0.207115760164555 no 2700 0.202176843688721 3903 6708538 A triterpene alcohol.
SGTC_2382 9035899 200 µM -0.83401730397838 0.207075010661367 no 2701 0.202135616472145 3878 6462679
SGTC_1745 st081495 74 µM -0.834032737007985 0.207070712786394 no 2702 0.202131268225944 3801 13842402 YBL026W LSM2
SGTC_1813 st051246 8.6015 µM -0.834320627299049 0.206990549189438 no 2703 0.202050165581242 3808 5291959
SGTC_1568 digitonin 820 nM -0.834965239667218 0.206811122260357 no 2704 0.201868640069409 3856 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2355 9061122 103.12 µM -0.835441456210972 0.206678627222465 no 2705 0.201734598251881 3912 5302957
SGTC_41 0478-0632 82.643 µM -0.835713798296516 0.206602877620786 no 2706 0.201657965433468 3809 3750424
SGTC_1403 3909-7815 62.9 µM -0.836505681553734 0.206382715558775 no 2707 0.201435240909614 3820 6615483
SGTC_466 geldanamycin 89.2 µM -0.837274954955448 0.206168972746952 no 2708 0.201219016848023 3779 5288382 HSP90 inhibitor.
SGTC_1271 0832-2808 169 µM -0.838273559369007 0.205891706097564 no 2709 0.200938541083784 3935 3663794
SGTC_2747 doxorubicin 7.63 µM -0.842307281268148 0.204773980034283 no 2710 0.199807988223211 3782 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2837 9008476 45.46 µM -0.844050833968392 0.204291968711497 no 2711 0.199320500034951 3882 2992805
SGTC_3201 9113999 49.47 µM -0.844284129841791 0.204227524523272 no 2712 0.199255326101956 3943 16649224
SGTC_1149 3909-7961 23.3 µM -0.844962317160566 0.204040255073221 no 2713 0.199065939432051 3919 735261
SGTC_592 k241-0073 46.5 µM -0.845294099654283 0.203948676476393 no 2714 0.198973327291921 3883 4230158
SGTC_1490 4089-0339 670 nM -0.847206855719268 0.203421195386943 no 2715 0.198439916451412 3831 742542
SGTC_116 0155-0182 31.788 µM -0.849782001184177 0.202712333996096 no 2716 0.197723149113147 3838 771486
SGTC_1570 verbenone 133 µM -0.849888979028441 0.202682918128314 no 2717 0.197693406731009 3939 29025 A natural terpanoid with antifungal properties.
SGTC_2306 7482397 179.52 µM -0.852996893384429 0.201829444004304 no 2718 0.196830513491893 3900 891448
SGTC_3177 9107506 49.47 µM -0.853898208860188 0.201582334026731 no 2719 0.196580696046612 3823 8897194
SGTC_1917 st066507 28.5 µM -0.853925438130811 0.201574871510711 no 2720 0.19657315190523 3892 3156428
SGTC_865 0488-0499 301 µM -0.856102003746769 0.200978892496255 no 2721 0.195970680207095 3879 9634651
SGTC_2561 acetosyringone 100 µM -0.856772001770579 0.200795649153668 no 2722 0.195785450992714 3920 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_790 1575-0012 79.1 µM -0.857702595696823 0.200541299687942 no 2723 0.195528353187705 3999 378741 YLR208W SEC13
SGTC_2941 9056145 11.23 µM -0.858217748936102 0.200400581497119 no 2724 0.195386118554053 3773 2119517
SGTC_1317 1273-0028 910 nM -0.858522566497264 0.200317346102327 no 2725 0.195301987542981 3895 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_918 glabranin 770.725 nM -0.864103068013082 0.198797173177862 no 2726 0.193765636892118 3948 124049 Also referred to as licorice root.
SGTC_1113 artemisinin 1.17947 µM -0.865268790310483 0.19848050154799 no 2727 0.193445638252013 3947 2240 An anti-malaria and mitochondrial poison.
SGTC_1621 st003705 32.4 µM -0.866489905753015 0.198149108787384 no 2728 0.193110779788443 3953 24207032
SGTC_337 1315-0038 354 µM -0.867661663281487 0.197831425318925 no 2729 0.192789789359499 3893 1626437
SGTC_2647 atorvastatin 60.16 µM -0.868228995230498 0.197677722568865 no 2730 0.192634492035845 3907 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.868302062330225 0.197657932325957 no 2731 0.192614496737847 3926 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2150 5556613 200 µM -0.868645499019424 0.197564928452894 no 2732 0.19252052999732 3928 743190
SGTC_2859 9028643 45.46 µM -0.871399280197021 0.19682015166155 no 2733 0.191768089341581 3836 17151580
SGTC_1341 1486-1360 280 µM -0.872552973689397 0.196508634273355 no 2734 0.191453391143638 3903 3976547
SGTC_1464 k208-0027 110 µM -0.87266053720156 0.196479605480871 no 2735 0.19142406669256 3889 X1464
SGTC_2610 ononetin 44.17 µM -0.875146418363392 0.195809450450291 no 2736 0.190747121556607 3929 259632
SGTC_831 k061-1017 217 µM -0.876985101452968 0.195314663618064 no 2737 0.190247365192254 3992 1240153
SGTC_1970 st070122 35.8 µM -0.878498836267536 0.194907890525228 no 2738 0.189836534484617 3958 102928
SGTC_1428 4049-0204 61.7 µM -0.879042767567576 0.194761850396257 no 2739 0.189689043750387 4002 X1428
SGTC_2125 5246583 200 µM -0.880389803686778 0.194400471274893 no 2740 0.189324089111548 3912 835267
SGTC_1553 gossypol 38.6 µM -0.882451424193835 0.193848176537842 no 2741 0.188766368643027 3809 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2566 crystal violet carbinol 226 nM -0.88252959855964 0.193827252970816 no 2742 0.188745240445876 4001 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1795 st049545 62.3 µM -0.885286455264543 0.193090253859399 no 2743 0.188001076675428 3875 5291882
SGTC_927 2425-1185 123 µM -0.885770237339865 0.192961099574776 no 2744 0.187870675483975 3906 730375
SGTC_1481 3346-2004 36 µM -0.888182678138451 0.192317843173474 no 2745 0.187221247409427 3979 2770522
SGTC_328 k915-0120 63.5 µM -0.888194209022376 0.192314771715907 no 2746 0.187218146637449 3942 6624543
SGTC_574 1315-0397 40 µM -0.889658890991657 0.191924871386566 no 2747 0.186824536998351 3950 6794277
SGTC_2034 5197015 53.07 µM -0.889685230373451 0.191917864239114 no 2748 0.186817463405703 3952 780676
SGTC_2504 purpurogallin 52.29 µM -0.889942394089279 0.191849458406512 no 2749 0.186748409318872 3874 5281571 An antioxidant.
SGTC_2825 7998094 58.44 µM -0.890147144137388 0.191795005342216 no 2750 0.186693440748252 3964 2987815
SGTC_1030 k029-0042 36.7 µM -0.892663626287312 0.191126522631086 no 2751 0.186018667392534 3957 6080581
SGTC_1498 4478-3555 97.6 µM -0.892688500496249 0.191119922141356 no 2752 0.186012005139833 3891 3437919
SGTC_3139 9095020 49.47 µM -0.892698386025835 0.191117299007843 no 2753 0.186009357462693 3665 25236292
SGTC_602 3130-1533 38.1 µM -0.893851100720484 0.190811576590786 no 2754 0.185700781941215 4000 720941
SGTC_1600 coumarin 106 71.1 µM -0.895862933085337 0.190278718799161 no 2755 0.185162986588274 4035 100336 A hepatotoxic, DNA x-linker.
SGTC_2853 9015042 58.44 µM -0.897078289455526 0.189957260526338 no 2756 0.184838571349032 3890 6457456
SGTC_1257 0669-0121 16 µM -0.899863815596951 0.18922175725244 no 2757 0.184096364228346 3988 4307855
SGTC_1367 1812-0510 76.9 µM -0.901241261075688 0.188858698954501 no 2758 0.183730028583682 4006 1142582 YDR527W RBA50
SGTC_972 1319-0219 195 µM -0.901879201023725 0.188690700339174 no 2759 0.183560520572029 3942 23903702
SGTC_610 4215-0184 155 µM -0.902204928212506 0.18860495708605 no 2760 0.183474008695139 3985 5605015
SGTC_2787 5284540 71.43 µM -0.903572924769722 0.188245112959177 no 2761 0.183110951702259 4025 736958
SGTC_1098 clofazimine 15.1 µM -0.904170046631924 0.188088176164345 no 2762 0.182952620215995 4041 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3024 9090631 49.47 µM -0.904670307619124 0.187956758730466 no 2763 0.182820037930783 3935 25236383
SGTC_169 k015-0017 16.025 µM -0.906288938613621 0.187531936607553 no 2764 0.182391469347731 3943 1840002
SGTC_1708 st033234 31.827 µM -0.907678493947151 0.187167710885634 no 2765 0.182024054791072 4077 674664
SGTC_1882 5615643 20 µM -0.908449134390812 0.186965901845069 no 2766 0.181820488148885 3918 2253075
SGTC_56 0957-0365 83.25 µM -0.910190360597776 0.186510419694034 no 2767 0.18136106342619 3984 6752360
SGTC_957 1187-1561 14.1 µM -0.910269165477423 0.186489821629355 no 2768 0.181340287866615 3944 1538454
SGTC_642 0335-0876 158 µM -0.910926169056596 0.186318148498613 no 2769 0.181167138108457 4020 6812350
SGTC_105 0111-0055 734.78 µM -0.911409166417534 0.186192005158051 no 2770 0.181039912825629 3997 5179370
SGTC_2067 5224629 34.075 µM -0.912041973843259 0.186026816377192 no 2771 0.180873311138341 3994 2835000
SGTC_3251 9135047 49.47 µM -0.913969078551239 0.185524322633106 no 2772 0.18036654689111 3986 17682963
SGTC_686 1319-0111 510 µM -0.914873507700292 0.185288782897628 no 2773 0.180129019658457 4005 4562600
SGTC_3202 9113761 49.47 µM -0.914877260408596 0.185287805969891 no 2774 0.180128034506347 4027 4798415
SGTC_1392 3455-1037 33.9 µM -0.914911199788172 0.185278970810457 no 2775 0.180119124974299 4007 981132
SGTC_1107 amlodipine 47 µM -0.923932851632367 0.182939721310519 no 2776 0.177760638803421 3759 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1470 k295-0292 231 µM -0.924885820689974 0.182693704101908 no 2777 0.177512651490912 4079 5045612
SGTC_1248 0469-0687 58.6 µM -0.925752582306857 0.182470121562976 no 2778 0.177287287318631 4011 4017482
SGTC_871 0574-0004 149 µM -0.926524727234876 0.182271089567874 no 2779 0.177086676396305 3989 9551173
SGTC_991 3996-0057 64.7 µM -0.928018860874421 0.181886339536375 no 2780 0.176698893058375 4058 715343
SGTC_1945 st075991 56.6 µM -0.929133519230076 0.181599638161838 no 2781 0.176409947636465 4034 1084980
SGTC_3111 9122088 49.47 µM -0.931184362629652 0.181072879890597 no 2782 0.175879102667854 3863 16876704
SGTC_2862 9027634 71.43 µM -0.931966494504969 0.180872242049717 no 2783 0.17567692063614 3937 5012562
SGTC_986 1493-0483 84 µM -0.932171820737909 0.180819593454434 no 2784 0.175623867970913 3933 40079
SGTC_3132 9126706 49.47 µM -0.933613055011616 0.180450310700323 no 2785 0.175251764313207 4089 850858
SGTC_2225 6654152 15.4 µM -0.934701224517602 0.180171806270726 no 2786 0.174971147834998 3886 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_759 3486-0358 89.3 µM -0.936102940016028 0.179813451218835 no 2787 0.174610094730896 3990 875103
SGTC_2398 5228213 48.84 µM -0.937097103362839 0.179559560339566 no 2788 0.174354305653772 4029 80771 YMR134W ERG29
SGTC_1142 3253-1408 9.78 µM -0.938190368804451 0.17928062087764 no 2789 0.174073293509187 3994 256655
SGTC_1064 honokiol 6.76 µM -0.939958957172425 0.178829954563545 no 2790 0.173619306848793 4025 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2551 apiole 73.87 µM -0.941119774867795 0.178534546491435 no 2791 0.173321741382254 3863 10659 A possible DNA adduct former.
SGTC_1496 4469-0713 57.4 µM -0.942243441542101 0.178248885647777 no 2792 0.173034008727018 3988 746691
SGTC_323 4013-0906 34.3 µM -0.94428710134515 0.177730081099204 no 2793 0.172511477753229 4019 2910086
SGTC_2345 9052315 157.45 µM -0.944850678624096 0.177587178826104 no 2794 0.172367557300337 4072 6469265
SGTC_2838 9002687 71.43 µM -0.94508397709244 0.177528044223903 no 2795 0.172308002407555 3999 6457060
SGTC_3056 9094900 49.47 µM -0.945177211401619 0.177504415424226 no 2796 0.172284205840596 4006 25236784
SGTC_1308 1187-1617 41.4 µM -0.946142262663323 0.177259954671216 no 2797 0.172038015121992 4032 2882570
SGTC_3183 9108214 49.47 µM -0.948469020351193 0.176671429741178 no 2798 0.171445368395728 3963 4974831
SGTC_1471 k673-0312 37 µM -0.9485744553178 0.176644790547938 no 2799 0.171418544072588 3976 24099884
SGTC_603 3794-0023 45.9 µM -0.94895980853058 0.1765474488323 no 2800 0.171320526940525 4059 3802260
SGTC_2092 5303694 80.6725 µM -0.949051637922875 0.176524257378167 no 2801 0.171297174816158 4020 1963699
SGTC_1187 1391-0724 117 µM -0.949060593678036 0.17652199571107 no 2802 0.171294897485321 4084 6997986
SGTC_2401 5128683 200 µM -0.949937198805614 0.176300708440101 no 2803 0.171072081996625 4017 708373
SGTC_868 0527-0199 213 µM -0.952407953591651 0.175677944481662 no 2804 0.170445063668265 3980 2849450
SGTC_3107 9121808 49.47 µM -0.953462703077513 0.175412515542183 no 2805 0.17017784236772 3917 662681
SGTC_3062 9077494 49.47 µM -0.954181520562358 0.175231770029575 no 2806 0.169995883504727 4028 16459633
SGTC_2980 9014342 25.29 µM -0.954627659516491 0.175119648522685 no 2807 0.169883012246085 4114 2996599
SGTC_1987 st072290 61.9 µM -0.955886578456138 0.174803508487357 no 2808 0.169564770269336 4066 54697379
SGTC_2819 7996655 46.38 µM -0.95742478134179 0.17441772664805 no 2809 0.16917644765666 4007 6456960
SGTC_1951 sophoraflavanone G 9.2 µM -0.957496109160266 0.174399850736353 no 2810 0.169158454659655 4008 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_276 colchicine 750 µM -0.958351255088501 0.174185627881656 no 2811 0.16894283312757 4116 2833 A microtubule depolymerizer.
SGTC_1685 st024049 53.0905 µM -0.959893680384882 0.173799657534508 no 2812 0.168554363561711 4067 1941139
SGTC_2804 7954240 19.48 µM -0.960135498678266 0.173739195255308 no 2813 0.168493512208912 4086 828705
SGTC_1937 st074714 47.2 µM -0.960819428741001 0.173568263392852 no 2814 0.168321483968622 4000 17250970
SGTC_2619 obliquin 87.91 µM -0.961714577856157 0.173344704162775 no 2815 0.168096498761942 3983 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1497 4476-2978 41.3 µM -0.9672760411275 0.171959865411 no 2816 0.166703028777767 4092 1528379
SGTC_739 1486-1183 203 µM -0.970094370428153 0.171260788235284 no 2817 0.165999727419749 4060 4346692
SGTC_1821 st053465 65.6 µM -0.971974878901826 0.170795346537281 no 2818 0.165531523081317 4056 675086
SGTC_2325 6158266 200 µM -0.972000436046554 0.170789026509377 no 2819 0.165525165815523 4091 3623240
SGTC_125 0133-0007 11.75 µM -0.972319915709437 0.170710034993339 no 2820 0.165445709499899 4131 26541
SGTC_462 ag-879 158 µM -0.97293758246836 0.170557382881484 no 2821 0.16529216242281 4075 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.97352515210426 0.170412250209892 no 2822 0.165146182866433 4062 616764
SGTC_1421 4029-0249 71.4 µM -0.974646023668489 0.170135608698811 no 2823 0.164867937888325 4130 2894095
SGTC_1912 st060209 90.8 µM -0.975521858731958 0.169919644881659 no 2824 0.164650732171445 4079 688787
SGTC_366 0181-0206 4.31 µM -0.979796660956692 0.168868085884131 no 2825 0.163593250333709 4089 274874
SGTC_2103 5378138 10 µM -0.980150807541319 0.168781157264134 no 2826 0.163505841345703 4127 244142
SGTC_1444 4112-3581 28 µM -0.980229971200568 0.168761729730118 no 2827 0.163486306648801 4084 2877249
SGTC_3231 9132313 49.47 µM -0.983432690139261 0.167976956512731 no 2828 0.162697263926464 4038 4905967
SGTC_2292 7671323 168.05 µM -0.987618650652405 0.166954803371123 no 2829 0.161669724319868 4147 937504
SGTC_262 fenpropimorph 62.5 µM -0.9960232014905 0.16491466966133 no 2830 0.159619436117618 4048 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.996784204245245 0.164730743121033 no 2831 0.159434633509032 4072 688662
SGTC_1920 st075728 45.7 µM -0.997465935075725 0.16456608868189 no 2832 0.159269200362024 4050 3400306
SGTC_1841 st054148 70 µM -0.998751994844093 0.164255764712796 no 2833 0.158957423079929 4104 675442
SGTC_2848 9016370 25.97 µM -0.999847526791869 0.163991714272987 no 2834 0.158692150796775 4072 7894410
SGTC_768 0384-0033 77.3 µM -0.999869372182548 0.163986451792722 no 2835 0.158686864103537 4053 3965305 YMR134W ERG29
SGTC_1188 1403-0014 4.57 µM -1.00260125223999 0.163329214810686 no 2836 0.158026645690419 4083 9614867
SGTC_1263 0774-1208 64.8 µM -1.00305715303049 0.163219700833212 no 2837 0.157916643147478 4143 906585
SGTC_1893 st059353 36.1 µM -1.0035892256366 0.163091949634629 no 2838 0.157788324999213 4103 3112488
SGTC_446 go6976 132 µM -1.00459310458414 0.16285109426376 no 2839 0.157546409459443 4120 3501 A protein kinase C inhibitor.
SGTC_1020 4335-0961 93.3 µM -1.00462934103213 0.162842404571699 no 2840 0.157537681731521 4026 669075
SGTC_2220 6782180 200 µM -1.00661463782355 0.162366780701037 no 2841 0.157059998711318 4005 833803
SGTC_3054 9094397 49.47 µM -1.01277035417661 0.160897790633085 no 2842 0.155584932072364 4109 2598354
SGTC_45 0kpi-0036 14.9 µM -1.01323347035918 0.160787625353293 no 2843 0.155474328433819 4121 2795021
SGTC_2014 4013930 200 µM -1.01537626260597 0.160278542899917 no 2844 0.154963251907494 4040 64556
SGTC_3049 9092223 49.47 µM -1.01635943349331 0.160045315097511 no 2845 0.154729127958089 4086 8623917
SGTC_442 cape 100 µM -1.01655269728434 0.159999495171965 no 2846 0.154683133263766 4086 5281787
SGTC_2149 5554786 194.827 µM -1.01680377508171 0.159939981231699 no 2847 0.154623392954496 4135 745063 YPR165W RHO1
SGTC_1309 pyrazolanthrone 13.4 µM -1.01779849199735 0.159704341959691 no 2848 0.154386864418591 4083 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2010 4012422 159 µM -1.01896594064768 0.159428074034919 no 2849 0.154109568202878 4081 952393
SGTC_2858 9025781 8.96 µM -1.01968336054847 0.159258457326814 no 2850 0.153939327829252 4029 4894980 YPL153C RAD53
SGTC_244 nsc-207895 1.295 µM -1.02154229806367 0.158819506242126 no 2851 0.153498789887859 3895 42640
SGTC_2252 omeprazole 400 µM -1.02263168938556 0.158562637057877 no 2852 0.153241010287774 4073 4594 A proton pump inhibitor.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.02403514635461 0.158232115690394 no 2853 0.152909337281005 3958 4000243
SGTC_808 0711-0032 135 µM -1.02549293472032 0.157889278050681 no 2854 0.152565328717819 4041 4252555
SGTC_35 0133-0054 64.071 µM -1.02630654690103 0.157698147791611 no 2855 0.152373556146576 4131 99677
SGTC_2784 7567673 72.73 µM -1.02729541147825 0.157466052704352 no 2856 0.152140691181434 4090 3471247
SGTC_1899 st063254 59.6 µM -1.02768310035437 0.157375120056523 no 2857 0.152049459927598 4066 3093813
SGTC_2913 7966556 36.57 µM -1.03064974091186 0.156680435664895 no 2858 0.151352550682781 3991 2976516
SGTC_2050 5263056 171 µM -1.03160269228422 0.156457716448562 no 2859 0.15112913932891 4125 763468 YGL055W OLE1
SGTC_1329 1447-1697 50.6 µM -1.03179346090242 0.15641315598056 no 2860 0.151084441618595 4129 2840515
SGTC_2580 diallyl disulphide 81.36 µM -1.03214867279251 0.156330206492385 no 2861 0.151001237752799 4114 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_518 1021-0119 62.6 µM -1.03370685783638 0.155966679718382 no 2862 0.15063661306247 4092 1097762
SGTC_3348 9149464 3.537 µM -1.03465907244965 0.155744801214089 no 2863 0.150414077991792 4082 1951442
SGTC_3292 9120825 59.784 µM -1.03505263676818 0.155653156383989 no 2864 0.150322164975539 4136 24824900
SGTC_3224 9130643 49.47 µM -1.04032485301721 0.154428905630935 no 2865 0.149094500695368 4195 17644395
SGTC_293 4049-0273 38.5 µM -1.04103581170137 0.154264303766731 no 2866 0.148929463972811 4006 1380311
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.04126019788825 0.154212377749632 no 2867 0.148877401963284 4182 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3281 9140613 49.47 µM -1.04204775331382 0.154030218206918 no 2868 0.148694769868828 4145 16013766
SGTC_2726 cimetidine 79.27 µM -1.04282353001131 0.153850922293103 no 2869 0.148515015706367 4122 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2366 9070441 60.58 µM -1.04364348336502 0.153661566575163 no 2870 0.148325183444976 4122 6837235
SGTC_905 2-aminofluorene 215 µM -1.04522764859489 0.153296165002241 no 2871 0.147958883862745 4145 1539 An established DNA mutagen. YPR165W RHO1
SGTC_145 3737-0113 38.366 µM -1.04761850222328 0.1527457846427 no 2872 0.147407204721788 4102 6849351
SGTC_1054 3429-0080 167 µM -1.05112239547726 0.151941550550365 no 2873 0.146601189734779 4192 1162877
SGTC_785 1270-0111 65.3 µM -1.05172633975707 0.151803214449069 no 2874 0.146462561357274 4072 6741994
SGTC_2583 asiatic acid 100 µM -1.0542882813834 0.151217321158636 no 2875 0.145875476132508 4180 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_200 k038-0079 37.545 µM -1.06079569031266 0.14973590571584 no 2876 0.144391380607196 4121 3436683
SGTC_417 st075190 100 µM -1.06292400077317 0.149253502770314 no 2877 0.143908208916389 4166 222757
SGTC_1851 st056236 18.9 µM -1.06395613462216 0.149019933339025 no 2878 0.143674285748268 4176 5393171
SGTC_2158 5657123 3.6195 µM -1.06414933955415 0.148976238669465 no 2879 0.143630526245178 4114 2858827
SGTC_764 1951-2361 146 µM -1.06452405931385 0.148891517532026 no 2880 0.143545680605495 4156 5438930
SGTC_1668 st014914 51.6 µM -1.06490704932932 0.148804959829424 no 2881 0.143458997345858 4164 2839556
SGTC_2890 9046729 58.44 µM -1.06668296152066 0.148404034164606 no 2882 0.143057511825697 4109 903329
SGTC_3337 9144342 33.5465 µM -1.07337076817101 0.146900699094791 no 2883 0.141552397353423 4166 17682949
SGTC_3090 9117696 49.47 µM -1.07405132429222 0.146748293243876 no 2884 0.141399839475167 4128 7923821
SGTC_2153 5569715 200 µM -1.0750961844537 0.146514510549733 no 2885 0.141165833784135 4201 2054701
SGTC_493 zm226600 134 µM -1.07821958856882 0.145817154396589 no 2886 0.140467886079815 4213 5240098 A potassium channel opener. YCR052W RSC6
SGTC_751 0833-0568 350 µM -1.07851281796795 0.14575180039814 no 2887 0.140402482312038 4192 6954252
SGTC_2180 6301957 200 µM -1.08048853962921 0.145311971397629 no 2888 0.139962343726426 4191 845462
SGTC_2902 5787006 60.46 µM -1.08120261374555 0.145153226351937 no 2889 0.139803497810298 4138 591003
SGTC_4 0960-0234 25.671 µM -1.08193744383546 0.144989988954264 no 2890 0.139640162711831 4188 6821112
SGTC_3345 9148410 3.559 µM -1.08358811342881 0.144623754906918 no 2891 0.139273731736937 4136 4903596
SGTC_1626 st003712 1.76 µM -1.0843056222145 0.144464755716918 no 2892 0.139114656662532 4211 24207035
SGTC_3197 9113331 49.47 µM -1.08556531912364 0.144185893237869 no 2893 0.138835675178693 4203 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_415 dibenzyl ketone 100 µM -1.08673706960464 0.143926825693637 no 2894 0.138576513187225 4164 7593
SGTC_400 oxethazaine 37.5 µM -1.08713897191952 0.143838039676557 no 2895 0.138487698378697 4180 4621 A local anesthetic.
SGTC_2840 9008771 71.43 µM -1.08793296153253 0.143662744547016 no 2896 0.138312351774341 4120 2992978
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.08926104885539 0.143369854982891 no 2897 0.138019392136836 4277 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_928 2764-0428 58.7 µM -1.08950681881777 0.143315698378374 no 2898 0.137965224762603 4208 662578
SGTC_2261 9010538 184.68 µM -1.09068472880884 0.14305633197822 no 2899 0.137705816264314 4191 6457250
SGTC_631 k072-0230 41.5 µM -1.09591376993678 0.141908769147868 no 2900 0.136558256222631 4202 5773147
SGTC_2779 methotrexate 400 µM -1.09846536125731 0.141351067104531 no 2901 0.136000667551835 4211 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_176 1486-1328 72.834 µM -1.09879639531724 0.141278821914261 no 2902 0.135928442437128 4257 22310231
SGTC_376 3970-0862 59.1 µM -1.10117484537627 0.140760482757234 no 2903 0.135410283692241 4234 3135186
SGTC_987 1497-1013 404 µM -1.10208485023825 0.14056250578381 no 2904 0.135212392517771 4211 1676435
SGTC_2988 9073640 71.4286 µM -1.10383774582165 0.140181685840014 no 2905 0.134831763954266 4256 9102229
SGTC_1427 4048-4900 550 nM -1.10566058878613 0.139786413690962 no 2906 0.134436727217242 4185 24132586
SGTC_372 0155-0182 15.9 µM -1.10683977109973 0.13953111931645 no 2907 0.134181604857518 4087 771486
SGTC_959 1222-0044 107 µM -1.10756107275449 0.139375113055042 no 2908 0.134025711445383 4197 6083612
SGTC_833 3852-0053 558 µM -1.11011190139835 0.138824360832522 no 2909 0.133475404670511 4273 3123681
SGTC_2847 9005661 71.43 µM -1.11391022224256 0.138007011079116 no 2910 0.132658851791653 4210 2991449
SGTC_1771 st048882 4.1505 µM -1.11397661911029 0.137992752577564 no 2911 0.132644608637554 4234 4580403
SGTC_2130 NSC 7 2.4545 µM -1.1159682342241 0.137565527060411 no 2912 0.132217866066048 4281 21448
SGTC_1041 0206-0046 107 µM -1.11656545141935 0.137437592904327 no 2913 0.132090085240402 4209 50494
SGTC_2976 9009005 19.48 µM -1.11977596546981 0.13675123813138 no 2914 0.131404621877811 4247 2993148
SGTC_1140 3229-1848 2.98 µM -1.12052228430383 0.136592023766526 no 2915 0.131245630918319 4239 2849525
SGTC_457 grayanotoxin iii 135 µM -1.12364773053801 0.135926640547544 no 2916 0.130581249415304 4054 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2070 5230947 200 µM -1.1242183072805 0.135805409153809 no 2917 0.130460212397258 4317 2835538
SGTC_96 0929-0093 37.281 µM -1.12473670389574 0.135695328777414 no 2918 0.130350311694572 4222 6991579
SGTC_2724 maprotiline 69.64 µM -1.125669702175 0.135497362678953 no 2919 0.130152676336104 4136 4011 A tricyclic antidepressant.
SGTC_1468 k284-1086 134 µM -1.12719461744475 0.135174228276541 no 2920 0.129830102869346 4203 15996457
SGTC_1610 st001799 48.1 µM -1.12841518224756 0.134915967707124 no 2921 0.129572309460993 4144 621897
SGTC_1342 1486-1464 234 µM -1.13117442118955 0.134333385568616 no 2922 0.128990842831992 4244 3253938
SGTC_2508 celastrol 40.54 µM -1.13333905370149 0.133877558767753 no 2923 0.1285359486851 4163 122724 Celastrol is a natural product and antioxidant.
SGTC_3347 9188721 44.724 µM -1.13356077900172 0.133830928101936 no 2924 0.128489416401611 4247 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2183 6420625 130.508 µM -1.13376940050497 0.133787063467789 no 2925 0.128445644818459 4225 2897619
SGTC_465 cgp-37157 41 µM -1.13487918297723 0.133553887386485 no 2926 0.128212971596977 4192 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_824 1304-0008 100 µM -1.13605504816614 0.13330713178675 no 2927 0.127966763233164 4248 768245
SGTC_3018 9082602 49.47 µM -1.13674354380768 0.13316279649413 no 2928 0.127822755243709 4168 17332089
SGTC_2095 5432005 200 µM -1.13798868583158 0.132902039816093 no 2929 0.127562603387201 4229 783734
SGTC_1181 1222-0449 220 µM -1.1394823152236 0.132589709186957 no 2930 0.127251020156757 4290 658318
SGTC_250 brefeldin a 552.239 µM -1.14032757808738 0.13241318174913 no 2931 0.127074926236174 4107 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2866 9034245 58.44 µM -1.14223941860271 0.132014504444194 no 2932 0.126677257563159 4205 6462273
SGTC_2221 6807166 181.081 µM -1.14226808608283 0.132008532702836 no 2933 0.126671301242015 4206 674925
SGTC_1087 pterostilbene 9.05 µM -1.1448553708827 0.131470340741333 no 2934 0.126134536928083 4254 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1607 st000305 50.6 µM -1.14684314041719 0.131057886718076 no 2935 0.125723227946458 4258 5457690
SGTC_184 1494-0393 24.714 µM -1.14938041407893 0.130532712842739 no 2936 0.125199576309831 4207 3090647
SGTC_1711 st032263 62.8 µM -1.15369894178178 0.129642198798587 no 2937 0.124311808956785 4253 3958979
SGTC_3217 9129673 49.47 µM -1.15389237541539 0.129602409978615 no 2938 0.124272147742844 4264 17248312
SGTC_797 k781-0471 270 µM -1.15451906487628 0.12947355960778 no 2939 0.124143713481282 4217 23738129
SGTC_3246 9135460 32.98 µM -1.15491392251565 0.129392420570079 no 2940 0.124062838730456 4216 41446951
SGTC_2421 5690543 90.72 µM -1.15530315854805 0.129312471206761 no 2941 0.123983151486246 4253 3397993
SGTC_2139 5578692 56.4705 µM -1.15612502254742 0.129143772228548 no 2942 0.123815011164852 4209 650991 YMR113W FOL3
SGTC_544 k015-0020 52.4 µM -1.15907615923096 0.12853926839771 no 2943 0.123212571380282 4249 3008304
SGTC_2080 5212524 12.4 µM -1.15980880674653 0.128389499406085 no 2944 0.123063328843549 4191 260183
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.16033455733174 0.128282099308663 no 2945 0.122956309965986 4235 688667
SGTC_813 k007-0158 173 µM -1.16143699403201 0.128057096622117 no 2946 0.122732115958185 4247 6523916
SGTC_2986 9022445 71.43 µM -1.16265299816055 0.12780923342959 no 2947 0.122485159346598 4256 6459286
SGTC_2198 6589944 200 µM -1.16308981787459 0.127720276097286 no 2948 0.12239653141437 4247 5290268
SGTC_2409 alverine citrate 63.97 µM -1.1657919857198 0.127170942381604 no 2949 0.121849279133833 4351 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2899 9053889 58.44 µM -1.16709080673925 0.126907486065466 no 2950 0.121586850033766 4223 6470052
SGTC_665 3914-0008 307 µM -1.16714570022913 0.126896359697993 no 2951 0.121575767462501 4204 1069549
SGTC_1560 lithocholic acid 53.1 µM -1.16759817444758 0.12680467351627 no 2952 0.121484443461329 4176 9903 A bile acid which acts as a detergent.
SGTC_1881 5652484 16 µM -1.16843434981543 0.126635358240668 no 2953 0.121315803026406 4239 2255129
SGTC_1450 4112-4260 37.6 µM -1.17003980017431 0.126310715714816 no 2954 0.120992476273401 4268 1633175
SGTC_1982 st072467 71.9 µM -1.17392766341978 0.125526944446745 no 2955 0.120212000453092 4240 3163533
SGTC_3013 9080133 71.4286 µM -1.17417052383375 0.125478098033182 no 2956 0.120163365003485 4348 17050193
SGTC_3298 9116858 71.43 µM -1.17617448361009 0.125075548766093 no 2957 0.119762579366158 4327 2506942
SGTC_1798 st045719 60.953 µM -1.17697360513911 0.124915275521082 no 2958 0.119603020763158 4201 3980186
SGTC_478 N-arachidonylglycine 10 µM -1.18037167140035 0.124235355759622 no 2959 0.118926211928289 4247 5283389
SGTC_2364 9055074 200 µM -1.1813472742475 0.124040626390274 no 2960 0.11873239723374 4280 6470630
SGTC_1167 k781-0610 148 µM -1.18355067813723 0.123601615310192 no 2961 0.118295487146925 4294 4525169
SGTC_559 1550-0661 158 µM -1.18418335619519 0.123475760445168 no 2962 0.1181702445525 4324 5830875
SGTC_15 0266-0086 27.098 µM -1.18517073064727 0.123279527348401 no 2963 0.117974974987974 4332 1712902 YIL048W NEO1
SGTC_748 act1.228 77.9 µM -1.19108566662704 0.122108554777732 no 2964 0.116809978080266 4227 4421505 YNR035C ARC35
SGTC_2820 7989630 71.43 µM -1.19148150911429 0.122030470096726 no 2965 0.116732305713905 4319 2984098
SGTC_3144 9087057 49.47 µM -1.19242622860355 0.121844254572915 no 2966 0.116547080489031 4187 17249618
SGTC_1748 st037455 53.6035 µM -1.1939846893698 0.121537499752384 no 2967 0.11624197859462 4323 580690
SGTC_2256 7954252 200 µM -1.1970502890822 0.120935676958906 no 2968 0.11564347705628 4280 2972920
SGTC_3055 9094636 49.47 µM -1.19939366489925 0.120477053766502 no 2969 0.115187454880692 4324 25236176
SGTC_580 1123-0028 41 µM -1.19990840038244 0.120376478927295 no 2970 0.115087458567682 4319 1677248 YPR107C YTH1
SGTC_3174 9107204 49.47 µM -1.20022079492258 0.120315468594691 no 2971 0.115026800606568 4312 3938802
SGTC_564 3555-0129 330 µM -1.20337131800032 0.119701392092968 no 2972 0.1144163309777 4164 563260
SGTC_2650 prasterone 100 µM -1.20625223964758 0.119141801950873 no 2973 0.113860123464329 4286 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1707 st032323 6.317 µM -1.20728606069623 0.118941443546468 no 2974 0.113660998503954 4147 3132057 YMR211W DML1
SGTC_2311 7694451 200 µM -1.20772670298622 0.118856117777226 no 2975 0.113576201598327 4258 2163142
SGTC_395 anisomycin 6.25 µM -1.21392626168998 0.117660219224429 no 2976 0.112387941730758 4303 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3119 9125183 49.47 µM -1.21444543322563 0.117560458597064 no 2977 0.112288837495618 4123 22695334
SGTC_613 3914-0030 117 µM -1.21512344074836 0.117430267261919 no 2978 0.112159507241141 4001 1145395
SGTC_325 2810-4341 181 µM -1.22188069199786 0.116138313657164 no 2979 0.110876373997255 4304 774970
SGTC_1340 1486-1359 257 µM -1.22276774834504 0.115969464791945 no 2980 0.110708715066917 4232 4309068
SGTC_1176 0848-0131 83.3 µM -1.22574759249164 0.115403535510766 no 2981 0.110146837199853 4355 6769040
SGTC_1776 st049249 45.9 µM -1.22725146159574 0.115118668454931 no 2982 0.1098640463895 4325 1822314
SGTC_268 camptothecin 39.6153 µM -1.23052726893244 0.114499887501135 no 2983 0.109249861017372 4285 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_505 gw-5074 63.9 µM -1.23196624452283 0.114228823121954 no 2984 0.108980846870941 4340 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1827 berberine 7.24 µM -1.23210803929271 0.114202137548505 no 2985 0.108954364363002 4228 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1884 5633444 25 µM -1.2323551124937 0.114155649333441 no 2986 0.108908230428164 4290 5724239
SGTC_1742 st038235 28.8875 µM -1.233326360647 0.113973034156986 no 2987 0.108727013403069 4345 564103 YBR002C RER2
SGTC_66 0109-0187 42.4 µM -1.23405882789573 0.113835452574747 no 2988 0.108590492000442 4182 759417
SGTC_279 1273-0055 2.93 µM -1.23834986585382 0.113031831175035 no 2989 0.1077931806868 4341 2847562
SGTC_2295 7971645 200 µM -1.24034906827888 0.11265880828283 no 2990 0.10742315530682 4374 2978226 YKL099C UTP11
SGTC_1103 duloxetine 36.1 µM -1.24167699548996 0.112411522259934 no 2991 0.107177880473268 4401 60835 A selective serotonin reuptake inhibitor.
SGTC_2659 sanguinarine 24.21 µM -1.24419730131717 0.11194325898431 no 2992 0.106713478375619 4265 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_156 3474-0145 5.642 µM -1.24440678513919 0.111904400560929 no 2993 0.1066749434806 4233 2265471
SGTC_3213 9129884 49.47 µM -1.24527841632123 0.111742819978141 no 2994 0.106514713315732 4307 17190742
SGTC_2213 7173844 200 µM -1.24771659352785 0.111291723930295 no 2995 0.106067431175498 4322 892728
SGTC_1194 1488-0194 225 µM -1.24950225519035 0.110962180174104 no 2996 0.105740714585263 4284 1391452
SGTC_1423 4048-0112 5.59 µM -1.25197330019833 0.11050730269716 no 2997 0.105289796571009 4387 X1423
SGTC_2541 muurolladie-3-one 83.07 µM -1.25330473116711 0.110262763741494 no 2998 0.105047413644568 4288 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_662 k832-1615 104 µM -1.25564953439063 0.10983304652419 no 2999 0.104621531810047 4360 5878478
SGTC_2744 captopril 92.04 µM -1.26240686298752 0.108601400278491 no 3000 0.103401210477366 4400 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1650 st011916 45.8 µM -1.26805000542073 0.107580472393028 no 3001 0.102390046775181 4262 242528
SGTC_261 5-fluorouridine 15.376 µM -1.2737644587109 0.106553709223222 no 3002 0.101373452252634 4359 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1234 0326-0494 15.5 µM -1.27564659509095 0.106217083868522 no 3003 0.101040237477688 4423 1547813
SGTC_2041 5107442 45.335 µM -1.278305279264 0.105742880717741 no 3004 0.100570903562369 4390 793005
SGTC_1872 amphotericin b 148 nM -1.27928129604393 0.105569182895757 no 3005 0.100399008337312 4361 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2001 4023502 57.655 µM -1.27985242819217 0.105467636523476 no 3006 0.100298520528578 4364 108941 YCR052W RSC6
SGTC_183 3914-0051 30.55 µM -1.2826690060324 0.104967886749266 no 3007 0.0998040314517714 4364 1596232
SGTC_2302 7771753 200 µM -1.28325447219105 0.104864222130885 no 3008 0.0997014687387005 4344 2203047
SGTC_1283 0922-0125 16.4 µM -1.28758781107216 0.104099250530957 no 3009 0.0989447422720351 4346 3360884
SGTC_2639 lactacystin 53 µM -1.29014230188444 0.103650201773664 no 3010 0.0985006273902412 4379 3870 A proteasome inhibitor.
SGTC_3178 9107506 49.47 µM -1.29040116610772 0.103604775107716 no 3011 0.0984557037311431 4361 8897194
SGTC_2675 theaflavin digallate 100 µM -1.29072244283921 0.103548416105927 no 3012 0.0983999697838653 4287 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_939 1165-0479 45.3 µM -1.29284000267876 0.103177506084034 no 3013 0.0980332008969908 4344 1377347
SGTC_3277 9138724 49.47 µM -1.29479391973569 0.102836116306734 no 3014 0.0976956650245687 4321 15943418
SGTC_3343 9148379 18.9835 µM -1.29521240746687 0.102763104676292 no 3015 0.0976234828989114 4380 1955036
SGTC_536 3852-0578 10.6 µM -1.2967404116238 0.102496840699689 no 3016 0.0973602598424677 4397 2869208
SGTC_655 k060-0012 42 µM -1.29832151857428 0.102221851654155 no 3017 0.0970884374952754 4345 5994525
SGTC_846 0335-0850 148 µM -1.29855025011652 0.102182114716374 no 3018 0.0970491603577735 4349 6819598
SGTC_1044 1222-0021 1.78 µM -1.29904471724802 0.102096250628892 no 3019 0.0969642917132471 4288 4306703
SGTC_1192 1488-0095 21.4 µM -1.29999320421168 0.101931693065452 no 3020 0.0968016491754301 4388 915875
SGTC_157 1348-1695 65.819 µM -1.30007348371688 0.101917773853552 no 3021 0.0967878923859904 4293 5380510
SGTC_1332 1480-0653 17.5 µM -1.3008599748386 0.101781481737681 no 3022 0.0966531942746993 4362 5749438
SGTC_2340 7987427 183.45 µM -1.30147283871973 0.101675369734506 no 3023 0.096548327857166 4387 2239331
SGTC_1816 st051957 91.6 µM -1.30400032841098 0.101238608116382 no 3024 0.0961167351994233 4361 674121
SGTC_1091 telmisartan 47.6 µM -1.30479855208359 0.10110095592617 no 3025 0.0959807261551917 4404 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1521 st012942 49.4 µM -1.30505311376836 0.101057085937376 no 3026 0.0959373812600598 4311 24207259
SGTC_2997 9067075 71.4286 µM -1.30635013652082 0.100833778447054 no 3027 0.0957167572643215 4333 27209819
SGTC_725 1497-0963 19 µM -1.30792482585224 0.100563149159324 no 3028 0.0954494040659513 4473 3549977
SGTC_2353 9059630 146.67 µM -1.30857540672609 0.100451493835514 no 3029 0.0953391080382682 4405 4779114
SGTC_2206 7254556 146.969 µM -1.30932624506657 0.100322744391602 no 3030 0.0952119315591999 4405 4398905
SGTC_1437 4092-1038 11.6 µM -1.30969483051928 0.100259585566191 no 3031 0.0951495465428037 4434 3977136
SGTC_553 k007-0256 45.7 µM -1.31072580607636 0.100083077259781 no 3032 0.0949752084048109 4429 6287000
SGTC_137 0438-0332 85.389 µM -1.31765750429654 0.0989022228990333 no 3033 0.0938091631423248 4331 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_792 4534-1957 155 µM -1.32013972657263 0.0984818506239263 no 3034 0.0933941856037986 4353 1717904
SGTC_1094 duloxetine 25.4 µM -1.32464027984513 0.097723006477675 no 3035 0.0926452447181533 4404 60834 A selective serotonin reuptake inhibitor.
SGTC_188 3229-0966 278.469 µM -1.33602566750764 0.0958224582082733 no 3036 0.0907704419505919 4436 5722370
SGTC_1698 5-fluorocytosine 1.055 µM -1.33760617808563 0.0955607895821003 no 3037 0.0905124247201265 4406 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_650 1328-0195 38 µM -1.33839961599661 0.0954296267809907 no 3038 0.0903831020110647 4405 2780821
SGTC_291 SEC14.278 35.5 µM -1.34007545393266 0.0951530305155802 no 3039 0.090110407666321 4422 1068044
SGTC_2989 9073649 71.4286 µM -1.3416416162735 0.0948950702802846 no 3040 0.0898561128520951 4372 21367202
SGTC_3200 9114385 49.47 µM -1.34362374172346 0.0945693365505828 no 3041 0.0895350440777909 4385 17018030 YLR208W SEC13
SGTC_2226 7298446 200 µM -1.34455149651554 0.094417156929769 no 3042 0.0893850578917205 4410 3283010
SGTC_1847 st056231 15 µM -1.34619184074575 0.0941485332742134 no 3043 0.0891203278782636 4388 5393180
SGTC_2096 5468907 200 µM -1.35233701950381 0.0931472076672284 no 3044 0.088133763464853 4392 759785
SGTC_672 1441-0018 53.7 µM -1.35405839369445 0.0928681346640857 no 3045 0.0878588743626272 4409 251141
SGTC_2627 acetyl isogambogic acid 100 µM -1.35754863881755 0.0923041867295695 no 3046 0.0873034749299112 4411 6857789 A caspase activator and apoptosis inducer.
SGTC_3164 9100705 49.47 µM -1.36254978080147 0.0915005341842413 no 3047 0.0865122225447243 4415 17174235
SGTC_141 0443-0274 32.331 µM -1.36427399586041 0.0912246690956705 no 3048 0.08624067349849 4356 1627241
SGTC_61 0978-8327 98.565 µM -1.36754450619927 0.0907031002463946 no 3049 0.0857273485203583 4334 6150059 YHR072W ERG7
SGTC_2930 9013230 14.89 µM -1.36895528294865 0.0904787993001074 no 3050 0.085506626657477 4393 2995857
SGTC_10 0279-0212 42.575 µM -1.36976238380521 0.090350662781801 no 3051 0.08538054392217 4412 39851 YBR002C RER2
SGTC_1819 st053448 58.6 µM -1.37413440665147 0.0896588954242129 no 3052 0.0846999798006428 4334 2857616
SGTC_477 mead ethanolamide 10 µM -1.37762973630448 0.0891086824107597 no 3053 0.0841588175429704 4385 16061185
SGTC_1664 st014217 9.02 µM -1.37876860644654 0.0889299524433162 no 3054 0.0839830544573358 4479 3982782
SGTC_1315 1237-0019 3.69 µM -1.38117611450126 0.0885530058677806 no 3055 0.0836124084990297 4426 825140
SGTC_1907 st060210 83.7 µM -1.38144828169243 0.0885104673034482 no 3056 0.0835705846667955 4412 688793
SGTC_942 3253-1115 227 µM -1.38345590497244 0.0881971546134784 no 3057 0.083262559472808 4445 46497897
SGTC_384 k007-0144 5.16 µM -1.39388188236952 0.0865833451157752 no 3058 0.0816766381067243 4363 6824886
SGTC_1979 st071809 45.3 µM -1.39646078841748 0.0861875895367716 no 3059 0.0812878903172989 4476 4976333
SGTC_333 3486-0131 40.1 µM -1.39811367156674 0.0859346527164847 no 3060 0.0810394675059714 4452 6744690
SGTC_2027 5150920 200 µM -1.39828182498074 0.0859089517582546 no 3061 0.0810142267563358 4367 786715
SGTC_887 0885-0007 9.62 µM -1.39931597183783 0.0857510168125536 no 3062 0.0808591260842449 4462 5719458
SGTC_1007 4101-0031 70 µM -1.39965305640531 0.0856995842424919 no 3063 0.0808086188357938 4418 1146276
SGTC_1692 fluoroquinolonic acid 71 µM -1.39971019253728 0.0856908686659597 no 3064 0.0808000601740248 4452 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1522 st012842 45.6 µM -1.40631819668776 0.0846873505128149 no 3065 0.0798148295429907 4278 3491067 YOR116C RPO31
SGTC_3308 9128332 17.569 µM -1.41114119126117 0.0839604935454286 no 3066 0.0791014931985004 4415 17332805 YDL196W YDL196W
SGTC_490 phenamil 164 µM -1.41173394992751 0.0838714851555749 no 3067 0.0790141564937047 4446 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2108 5365811 200 µM -1.41244102856457 0.0837654032352824 no 3068 0.0789100714976654 4446 780283
SGTC_1962 st076595 64.5 µM -1.41287214754108 0.0837007725966783 no 3069 0.0788466599327815 4414 279619
SGTC_2109 5483026 200 µM -1.41376532302476 0.0835669925756116 no 3070 0.0787154091785412 4448 759335
SGTC_2707 st078556 66.6 µM -1.41440014269492 0.0834720068696574 no 3071 0.07862222411276 4377 17250899
SGTC_1968 st069590 43.6 µM -1.41484093000992 0.083406101248554 no 3072 0.078557570219487 4403 6384066
SGTC_1043 0916-0009 19.3 µM -1.41580013809135 0.0832628175864051 no 3073 0.0784170145791449 4457 3101130
SGTC_976 1348-1067 47.6 µM -1.41780709508722 0.0829636230848039 no 3074 0.0781235460776084 4477 5310671 YGL099W LSG1
SGTC_1284 0929-0043 16 µM -1.41840135108684 0.0828751875510694 no 3075 0.078036810696234 4452 1239883
SGTC_1714 st033236 13.627 µM -1.41845911716879 0.0828665947460869 no 3076 0.0780283832727527 4453 2916566
SGTC_2411 st077133 39.94 µM -1.42222629834593 0.082307666068034 no 3077 0.077480283319342 4426 1403142 YNL221C POP1
SGTC_3179 9107801 49.47 µM -1.42249995643682 0.0822671748741416 no 3078 0.0774405820754057 4437 4818259
SGTC_3128 9127691 49.47 µM -1.42453648530424 0.0819663156459233 no 3079 0.0771456156069586 4465 41316314
SGTC_2645 abamectin 100 µM -1.42640592253334 0.0816908716097794 no 3080 0.0768756025659086 4401 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2406 ethylparaben 405.7 µM -1.42846046826221 0.0813889590703148 no 3081 0.076579682629803 4417 8434 A possible steroid mimic.
SGTC_255 tunicamycin 200.472 nM -1.43288442356832 0.0807417234988368 no 3082 0.0759454346982315 4377 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3319 9138450 16.7555 µM -1.43497800469631 0.0804367856364059 no 3083 0.0756466827473768 4385 2029690
SGTC_2181 6316240 54.2555 µM -1.43590945864163 0.0803013959179547 no 3084 0.075514053330599 4458 12779990
SGTC_1088 bifonazole 369 nM -1.43929498328252 0.0798107497157534 no 3085 0.0750334818085132 4446 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1556 plumbagin 1.48 µM -1.44340691626214 0.0792178824132465 no 3086 0.0744529384709365 4393 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1891 st059073 26.2 µM -1.44449451603247 0.0790616289543191 no 3087 0.0742999606137681 4532 688754
SGTC_635 k038-0028 24.7 µM -1.44714386707324 0.0786819784900735 no 3088 0.0739283170559292 4463 4035102
SGTC_1183 1254-0324 198 µM -1.45711448210447 0.0772655722071769 no 3089 0.0725423907076889 4513 5799357
SGTC_2297 7971671 152.32 µM -1.46377471563786 0.0763302789696773 no 3090 0.0716277565336759 4470 909016
SGTC_2026 5148700 152 µM -1.46572215544932 0.0760584353309997 no 3091 0.0713619978933129 4452 79838
SGTC_2792 7535235 81.82 µM -1.46836549694097 0.075690630574937 no 3092 0.0710024842523909 4449 1281891
SGTC_3297 9117502 71.43 µM -1.47542554448544 0.074714911119131 no 3093 0.0700490859690194 4502 7453720
SGTC_1287 0971-0001 34.6 µM -1.47543801476152 0.0747131962222143 no 3094 0.0700474107232247 4462 4665869
SGTC_1386 3228-0095 33.8 µM -1.47567591500529 0.0746804862273985 no 3095 0.0700154573186925 4476 870181
SGTC_923 1900-2434 73.3 µM -1.4774851326601 0.0744320860826501 no 3096 0.0697728203423043 4459 5910570
SGTC_682 0kpi-0099 17 µM -1.4778060377695 0.0743880927163291 no 3097 0.0697298509221192 4491 1714895 YML126C ERG13
SGTC_1545 lovastatin 49.4 µM -1.4778968983384 0.0743756401107762 no 3098 0.069717688328949 4502 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3261 9137475 49.47 µM -1.48059246026966 0.0740069320711201 no 3099 0.0693576028710561 4496 17027690
SGTC_2462 5162487 171.77 µM -1.48322360892494 0.0736483831435567 no 3100 0.0690075053031152 4446 2259986
SGTC_2207 7258803 200 µM -1.48911737746801 0.0728500548814243 no 3101 0.0682282312841214 4506 3666799
SGTC_378 3970-0959 8.33 µM -1.49078914388542 0.0726248196609212 no 3102 0.0680084314404507 4506 6615653
SGTC_2648 atorvastatin 78.68 µM -1.49200760912106 0.0724609935022324 no 3103 0.0678485752940179 4479 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_839 0122-0028 230 µM -1.49368423536137 0.0722360292802365 no 3104 0.0676290854418405 4505 759448
SGTC_2953 9074162 66.49 µM -1.49670329366018 0.0718322921555735 no 3105 0.0672352394380811 4468 16451992
SGTC_1289 0976-0073 69.1 µM -1.49999466000356 0.0713941136534636 no 3106 0.0668078928951272 4549 3391136
SGTC_2346 9031566 143.75 µM -1.50211575188594 0.0711128223060828 no 3107 0.0665336087459018 4468 4771086
SGTC_2843 9000894 45.46 µM -1.50358788525535 0.0709180942814651 no 3108 0.0663437562021077 4483 2242070
SGTC_203 k066-0004 30.888 µM -1.50628690973189 0.0705621421568826 no 3109 0.0659967685317359 4561 6795412
SGTC_1434 4073-0095 163 µM -1.50959208661949 0.070128121953251 no 3110 0.0655737709112851 4499 24133745
SGTC_514 4466-0038 2.65 nM -1.50990100885315 0.0700876609143025 no 3111 0.0655343426154524 4282 5722064
SGTC_2058 5236698 133 µM -1.51055564077526 0.0700019799567694 no 3112 0.0654508515337804 4466 766665
SGTC_1732 st034308 51.822 µM -1.51465318655995 0.0694675058625868 no 3113 0.0649301277185488 4384 830119
SGTC_718 1130-0073 349 µM -1.51763559346989 0.0690804680205886 no 3114 0.0645531443829497 4514 6740020
SGTC_216 k038-0035 28.382 µM -1.5248038421847 0.0681570164373795 no 3115 0.0636540156523556 4438 4444231 YPR107C YTH1
SGTC_2865 9030313 51.95 µM -1.53032979127616 0.0674516613702272 no 3116 0.0629675588721422 4496 42562754
SGTC_1 0258-0098 57.368 µM -1.53843453453933 0.0664273602676081 no 3117 0.0619712018793132 4426 6790032 YDR047W HEM12
SGTC_327 1273-0057 3.96 µM -1.5400199339096 0.0662284085410891 no 3118 0.061777747253297 4423 3108138
SGTC_840 0245-0196 390 µM -1.54864895803619 0.0651536342080365 no 3119 0.0607330650341699 4575 3827528
SGTC_1948 st076329 66.6 µM -1.54963300707467 0.0650319322582251 no 3120 0.0606148129842113 4445 24208413
SGTC_1726 st035556 14.5795 µM -1.557132795445 0.0641101869494565 no 3121 0.0597194800512995 4551 5919439
SGTC_207 4185-0010 4.486 µM -1.55805652902141 0.0639973635160726 no 3122 0.0596099241816293 4590 3761753
SGTC_2448 5185112 27.17 µM -1.56123477842511 0.0636103560368014 no 3123 0.0592341829813282 4527 5718189
SGTC_1555 citronellol 128 µM -1.56638428726987 0.0629871817256421 no 3124 0.0586293395970454 4497 8842 A terpine precursor.
SGTC_2480 5767542 37.17 µM -1.5714478682371 0.0623790535209912 no 3125 0.0580393272808166 4458 2867358
SGTC_2748 diazoxide 86.69 µM -1.5733038963146 0.0621572976189055 no 3126 0.0578242337927695 4613 3019 A potassium channel activatior.
SGTC_439 amiodarone 34.4 µM -1.57499467879383 0.0619558207930229 no 3127 0.0576288364072623 4403 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3033 9090887 49.47 µM -1.57522344815722 0.0619285993926896 no 3128 0.0576024383204474 4551 19325384
SGTC_2046 4110841 106 µM -1.57743797899354 0.0616655733499034 no 3129 0.0573473911885828 4538 44119630 YMR134W ERG29
SGTC_1491 4138-0063 26.5 µM -1.57832477650993 0.0615604908214479 no 3130 0.0572455083642806 4541 23883227
SGTC_2055 5235184 200 µM -1.58605964572963 0.0606498544470427 no 3131 0.0563628899386578 4545 2836034
SGTC_214 4373-3496 70 µM -1.58629110907001 0.0606227672189556 no 3132 0.0563366441167654 4598 3779166
SGTC_2374 9071832 200 µM -1.58727050301405 0.0605082573897508 no 3133 0.0562256964277436 4480 17381698
SGTC_269 exalamide 29 µM -1.58812836332572 0.060408096255672 no 3134 0.0561286579043831 4514 3316 A derivative of salicylamide.
SGTC_687 k029-0044 34.9 µM -1.59266619823661 0.0598804293889222 no 3135 0.0556175471490586 4596 5829338
SGTC_2238 6671620 73.2395 µM -1.60370461068604 0.0586119365780276 no 3136 0.0543895895577011 4464 729941
SGTC_2107 5363541 170.161 µM -1.6062669108983 0.0583205250111963 no 3137 0.0541076386678793 4483 244052
SGTC_2831 7999036 19.48 µM -1.60894229600844 0.058017467983554 no 3138 0.0538144799169975 4515 2988270
SGTC_811 0416-0114 265 µM -1.60929240996108 0.0579779002073477 no 3139 0.0537762089782955 4562 6612453
SGTC_3118 9124250 49.47 µM -1.61290487729716 0.0575708781710133 no 3140 0.0533825877075958 4516 1504786
SGTC_2247 cerulenin 830 nM -1.61565515927564 0.0572625093406437 no 3141 0.0530844454618792 4569 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2522 biochanin a 4.94 µM -1.61998796105222 0.056779342889664 no 3142 0.0526174315229908 4550 5280373 A possible chelator.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.62009091005117 0.056767901849184 no 3143 0.0526063748814597 4570 688788
SGTC_3069 9117009 49.47 µM -1.62116892193765 0.0566482080873919 no 3144 0.0524907079638206 4557 41904981
SGTC_2506 ethyl hematommate 54.16 µM -1.6214321742896 0.0566190088917595 no 3145 0.0524624925950016 4568 3940691 An allergen.
SGTC_3244 9134489 49.47 µM -1.62244146142663 0.0565071715255164 no 3146 0.0523544288190221 4559 16584271
SGTC_2629 bisabolol 100 µM -1.62383541741467 0.0563529960004857 no 3147 0.0522054694733661 4556 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2137 5261020 140 µM -1.62483277605915 0.0562428889136627 no 3148 0.05209909758502 4545 763655
SGTC_1200 1643-0193 18.4 µM -1.62844028786906 0.0558460400744119 no 3149 0.0517157804328334 4579 5403974
SGTC_1170 0310-0127 64.8 µM -1.63018746671531 0.0556546352202834 no 3150 0.0515309410032233 4567 774975
SGTC_1016 4226-1401 38 µM -1.63111666778358 0.0555530515989867 no 3151 0.0514328521635964 4571 2901613
SGTC_1393 3470-5649 58.2 µM -1.63266484693418 0.0553841242045214 no 3152 0.0512697522974858 4558 4108395
SGTC_2362 9071156 126 µM -1.63430346107638 0.0552057712410511 no 3153 0.0510975736577291 4553 653133
SGTC_512 prima-1 270 µM -1.63661132370977 0.0549553445365669 no 3154 0.0508558540265791 4566 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_608 k048-0125 159 µM -1.64261427425284 0.0543081663884548 no 3155 0.0502313827582683 4619 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1663 st014140 55.4 µM -1.64431137634134 0.0541262993232205 no 3156 0.0500559503091496 4635 4207120
SGTC_359 0081-0058 15.9 µM -1.64706504268501 0.0538322332589949 no 3157 0.0497723387127937 4553 3494159
SGTC_2474 5321570 43.32 µM -1.65206269399487 0.0533017632860389 no 3158 0.0492608854936479 4575 2841384
SGTC_2711 st079103 59.1 µM -1.65278439806705 0.0532255023718066 no 3159 0.0491873752402008 4508 54693780
SGTC_2441 5730946 39.09 µM -1.66243077064181 0.0522144736808862 no 3160 0.0482132167458754 4605 1774275
SGTC_805 3852-0218 479 µM -1.66432723757343 0.0520175121377678 no 3161 0.0480235260554745 4555 6615355
SGTC_2354 9060492 162 µM -1.66489738102482 0.0519584142387095 no 3162 0.0479666154097528 4570 6471895
SGTC_151 3013-0144 2.285 µM -1.66614902258599 0.0518288631492626 no 3163 0.0478418682418249 4329 906558 YHR107C CDC12
SGTC_1679 SEC14.276 6.7 µM -1.66639832240906 0.0518030900694724 no 3164 0.0478170523616873 4533 1005053 YMR079W SEC14
SGTC_605 1315-0399 119 µM -1.66672028287059 0.0517698202709009 no 3165 0.0477850189245562 4632 24020461
SGTC_1411 3909-8223 150 µM -1.67337979302137 0.0510854607341394 no 3166 0.0471262766199104 4612 X1411
SGTC_31 0508-1974 57.237 µM -1.67819142773038 0.0505954918310184 no 3167 0.0466548673443752 4537 6810525
SGTC_2717 st081029 62.2815 µM -1.67847654453641 0.0505665762633541 no 3168 0.046627052831497 4558 5292846
SGTC_2044 5102272 200 µM -1.67975637031755 0.0504369428575227 no 3169 0.0465023635628857 4586 592666
SGTC_965 1291-5240 308 µM -1.68148307658282 0.0502624647604936 no 3170 0.0463345604498539 4578 2834598
SGTC_2640 pentamidine 10.38 µM -1.68423159225631 0.0499857288094274 no 3171 0.0460684599838317 4534 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2745 rifampicin 24.3 µM -1.68558638414713 0.0498497685456342 no 3172 0.0459377467860006 4695 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2700 st077718 96.8 µM -1.68748767341072 0.049659462126754 no 3173 0.0457548090847237 4549 904970
SGTC_2960 9079389 5.97 µM -1.69033398399291 0.0493756493600978 no 3174 0.0454820384979226 4538 16457355
SGTC_1319 1306-0155 43.7 µM -1.69642758826027 0.0487723947690414 no 3175 0.0449024663634444 4622 3122360
SGTC_21 0849-0113 22.993 µM -1.69701095339562 0.0487149530969753 no 3176 0.044847294856253 4586 1560156
SGTC_2909 7941780 10.49 µM -1.69761228778048 0.0486557986761658 no 3177 0.0447904810543736 4535 1243215
SGTC_3095 9117207 49.47 µM -1.6982754626072 0.0485906274905383 no 3178 0.0447278918101734 4601 17015229
SGTC_3219 9131112 49.47 µM -1.69872284969028 0.0485467015257141 no 3179 0.0446857080225222 4456 17612988 YMR079W SEC14
SGTC_2208 7283366 200 µM -1.70398270591591 0.0480326486354684 no 3180 0.0441921591011771 4584 898663
SGTC_1634 st006576 41 µM -1.70616515691671 0.0478206376032251 no 3181 0.0439886670128695 4565 3915356
SGTC_1227 3909-8010 46.6 µM -1.70645377292357 0.0477926565995785 no 3182 0.0439618130719116 4597 15982272
SGTC_2351 9026858 72.31 µM -1.7130295155863 0.0471586900779008 no 3183 0.0433535548554505 4491 1409300
SGTC_159 3970-0959 50 µM -1.7202874198927 0.0464668019087726 no 3184 0.0426901045219121 4604 6615653
SGTC_2157 5649910 96.377 µM -1.72482148857968 0.0460387250043054 no 3185 0.0422798239660806 4583 2858091
SGTC_2315 7733312 200 µM -1.72582672572606 0.0459442474982525 no 3186 0.0421892951081651 4504 726316
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.7290643247407 0.0456410191910358 no 3187 0.0418987916149002 4621 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1202 1988-0068 29.6 µM -1.7376848611339 0.0448414737854494 no 3188 0.0411331788428865 4578 2850480
SGTC_2237 6667747 47.222 µM -1.73898707444492 0.0447216812883912 no 3189 0.0410185182631168 4601 729940 YDL015C TSC13
SGTC_55 0767-0285 6.563 µM -1.73919077389489 0.0447029660108343 no 3190 0.0410006058856904 4564 3116166
SGTC_2891 9063876 19.48 µM -1.74284308020641 0.0443684725300156 no 3191 0.0406805144348696 4634 6472478
SGTC_720 r052-1644 49.9 µM -1.74634840458569 0.0440493399546031 no 3192 0.0403752148000391 4614 1422863 YOR257W CDC31
SGTC_2691 st077356 60.2 µM -1.75473593925182 0.0432932302662024 no 3193 0.0396522428067505 4578 2839272
SGTC_1090 efavirenz 20.7 µM -1.75707605089741 0.0430841568672124 no 3194 0.039452423612413 4620 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_534 k292-0788 63.4 µM -1.76046304133497 0.042782997169488 no 3195 0.0391646643204946 4657 4146317
SGTC_2322 7413319 38.22 µM -1.76661768752184 0.0422401035038066 no 3196 0.0386461383875277 4541 1840400
SGTC_683 panaxydol 45 µM -1.76876860498377 0.0420516933231808 no 3197 0.0384662490080886 4623 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2767 sibutramine 71.45 µM -1.77091311632574 0.041864522060836 no 3198 0.038287575434074 4601 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2166 5933061 31.504 µM -1.77620016437808 0.0414059532960687 no 3199 0.0378499655961662 4601 2877375
SGTC_134 0269-0018 6.916 µM -1.77794759499979 0.0412552891209889 no 3200 0.0377062311136286 4570 4378915
SGTC_2815 7968870 71.43 µM -1.78015190770021 0.0410658666251287 no 3201 0.0375255517596945 4537 2977326 YHR190W ERG9
SGTC_2164 5685496 200 µM -1.78045987193916 0.0410394586748561 no 3202 0.0375003654491734 4573 759046
SGTC_2312 7706453 155.7 µM -1.78066587539393 0.04102180155614 no 3203 0.0374835255278554 4602 976098
SGTC_1218 1348-1416 30.7 µM -1.78560167127412 0.0406005801852891 no 3204 0.0370818880586321 4598 6787668
SGTC_1649 st011737 51.3 µM -1.78684582114275 0.0404949601452632 no 3205 0.0369812055877864 4634 1761035
SGTC_464 bw-b 70c 158 µM -1.79453457527127 0.039847175303656 no 3206 0.0363639425523875 4619 5353454
SGTC_1018 4259-0013 28.1 µM -1.79651875654781 0.0396813806128003 no 3207 0.0362060261995365 4651 6801262
SGTC_410 α-linolenic acid 100 µM -1.7969406286683 0.0396462021318329 no 3208 0.0361725228665748 4653 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2440 5628896 157.78 µM -1.7978614715451 0.039569504266796 no 3209 0.0360994815180315 4596 5522048
SGTC_1384 3089-0840 101 µM -1.80662031247387 0.0388459891074977 no 3210 0.0354107500885053 4621 1069836
SGTC_843 0310-0051 143 µM -1.81446083899792 0.0382075042578277 no 3211 0.034803403275726 4650 2065037
SGTC_196 k015-0023 18.111 µM -1.82051466437971 0.037720394340444 no 3212 0.0343403325647593 4595 5211998
SGTC_2935 9038016 29.96 µM -1.82398175340096 0.0374437120363339 no 3213 0.034077415409437 4585 6463195
SGTC_1941 st076221 61.8 µM -1.82909111887056 0.0370389952518003 no 3214 0.0336929795986519 4525 2828568
SGTC_2073 5212005 126 µM -1.83278691149022 0.0367484828928395 no 3215 0.03341713317117 4594 691789
SGTC_588 3970-1144 52.9 µM -1.83332639263135 0.0367062325960181 no 3216 0.0333770233597387 4565 1888707
SGTC_1077 5-fluorocytosine 377 nM -1.84106271003051 0.036104709391049 no 3217 0.0328061847381006 4668 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1474 0330-0125 5.35 µM -1.84508512807043 0.0357951575857814 no 3218 0.0325125781162686 4697 X1474
SGTC_3114 9122766 49.47 µM -1.85026100966666 0.0354000421102276 no 3219 0.0321379697075508 4632 17176985
SGTC_1594 piperine 70.1 µM -1.85282469712537 0.0352056643635949 no 3220 0.0319537445710829 4625 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3105 9121040 49.47 µM -1.85286304178365 0.0352027637465215 no 3221 0.0319509957792158 4631 41448907
SGTC_3040 9091894 49.47 µM -1.85355689054822 0.0351503107791853 no 3222 0.0319012899634067 4567 25236966
SGTC_1620 st003704 16.5 µM -1.85533828687145 0.0350159359578619 no 3223 0.031773967029378 4660 2834414
SGTC_2456 5770359 74.46 µM -1.86005176358083 0.0346624200389608 no 3224 0.0314391013809522 4606 3118787
SGTC_2860 9025725 38.96 µM -1.86886433425067 0.0340093318108982 no 3225 0.0308208457354703 4678 40546248
SGTC_3042 9091578 49.47 µM -1.87312094684438 0.0336975231500149 no 3226 0.0305258427190946 4645 25236497
SGTC_738 1315-0003 72.4 µM -1.88008829454809 0.0331922248030571 no 3227 0.0300480227551736 4641 6251474
SGTC_2910 7948405 25.97 µM -1.88275838161463 0.0330002416836374 no 3228 0.02986655977031 4635 2971328
SGTC_615 k087-0205 167 µM -1.8853162089977 0.0328171892811199 no 3229 0.0296935795256216 4666 9642773
SGTC_660 4031-1742 102 µM -1.88904104145908 0.0325521172657136 no 3230 0.0294431647817434 4543 6738706
SGTC_3151 9099821 49.47 µM -1.89159689513319 0.0323712574194249 no 3231 0.0292723549517914 4596 17174189
SGTC_1611 st001856 99.4 µM -1.89272561273047 0.0322916503434018 no 3232 0.0291971842240876 4659 647478
SGTC_3149 9097855 49.47 µM -1.90102066347088 0.031711554208172 no 3233 0.0286496530581594 4637 25236625 YMR079W SEC14
SGTC_1280 0880-0253 10.1 µM -1.90161576714909 0.031670270102078 no 3234 0.0286107025559118 4660 6836607
SGTC_1778 st046819 58.9 µM -1.92697221905586 0.0299520521257706 no 3235 0.0269915460971525 4702 671715
SGTC_326 k292-0812 17.5 µM -1.93587999761351 0.0293670942156714 no 3236 0.0264412000498743 4677 3579357
SGTC_373 0844-0104 25.9 µM -1.93750377742467 0.029261492422099 no 3237 0.0263418960389049 4683 5375804
SGTC_2794 7785382 27.27 µM -1.93927540110091 0.0291466356385107 no 3238 0.0262339062728596 4647 2205081
SGTC_628 1636-0253 16 µM -1.94039695340889 0.0290741176585539 no 3239 0.0261657332853867 4673 4456143
SGTC_1313 1220-0047 237 µM -1.9447918514254 0.0287913930293548 no 3240 0.0259000176230971 4677 3528706
SGTC_266 formosanin C 406 nM -1.94668986882603 0.0286700018852381 no 3241 0.0257859634789169 4523 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_91 0417-1751 58.384 µM -1.94678014926217 0.0286642384565402 no 3242 0.0257805489079169 4714 6795624
SGTC_2686 alizarin 95.37 µM -1.96338239673841 0.027620625355565 no 3243 0.0248008788461311 4649 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1301 naphtanilide LB 4.81 µM -1.97825342681836 0.0267129104605856 no 3244 0.023950062129959 4713 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2693 st077581 40.7 µM -1.98418550297613 0.02635783954259 no 3245 0.0236175820283764 4637 25238761
SGTC_2119 5528445 120.635 µM -1.98935540878571 0.0260516144575125 no 3246 0.023330993904791 4690 791935
SGTC_1136 pergolide 1.05886 µM -1.99798487205423 0.0255471028176934 no 3247 0.0228591501179068 4634 47811 A dopamine receptor agonist.
SGTC_2827 7993847 71.43 µM -2.00703082266713 0.0250270507226859 no 3248 0.0223731905724168 4694 2985692
SGTC_2829 7992743 58.44 µM -2.02510567817609 0.0240144844358101 no 3249 0.0214282569922547 4649 16462845
SGTC_18 0111-0177 500 nM -2.02729777197136 0.0238940555079214 no 3250 0.0213159846204441 4744 721752
SGTC_1815 st051655 58.2 µM -2.03110754084786 0.0236859627236566 no 3251 0.02112204333793 4679 5984156
SGTC_1935 st074532 41.6 µM -2.04762225618588 0.0228014532670508 no 3252 0.0202985134264144 4674 2829742
SGTC_1704 st028805 70.8 µM -2.05541220291258 0.0223939917156689 no 3253 0.0199196039195112 4717 2876101
SGTC_576 1073-0113 22.7 µM -2.06313038082337 0.0219963581400783 no 3254 0.0195501211982853 4731 5439563
SGTC_1349 flufenamic acid 69 µM -2.06714689780773 0.0217917997688459 no 3255 0.0193601570719087 4647 3371 A non-steroidal anti-inflammatory.
SGTC_2839 9003951 25.97 µM -2.07426434799577 0.0214332591796744 no 3256 0.0190273834852458 4728 2990634
SGTC_2148 5546263 113.568 µM -2.07496858114286 0.0213980562167545 no 3257 0.0189947233811851 4727 792097
SGTC_1913 st060213 96.1 µM -2.07997885835602 0.0211490125804666 no 3258 0.0187637360348035 4684 688959
SGTC_2919 7978188 46.38 µM -2.08222270130334 0.0210382763674295 no 3259 0.0186610663168645 4676 2980291
SGTC_2740 felodipine 17.08 µM -2.08465741371851 0.0209186759307978 no 3260 0.0185502044504981 4745 3333 L-type calcium channel blocker
SGTC_659 k018-0002 107 µM -2.09244046334803 0.0205402023798612 no 3261 0.018199566173653 4684 6797879 YHR007C ERG11
SGTC_2439 5492030 7.2 µM -2.0958623633031 0.0203756476494366 no 3262 0.0180472011267698 4699 5722370
SGTC_809 3998-0021 90 µM -2.10012183946888 0.0201723772538335 no 3263 0.0178590623103745 4678 715485
SGTC_358 0075-0058 9.45 µM -2.10648307544797 0.0198720099405541 no 3264 0.0175812058642033 4662 1069125
SGTC_754 3474-0146 171 µM -2.11006672337282 0.0197044733615445 no 3265 0.0174263045365515 4711 24762078
SGTC_3089 9117425 49.47 µM -2.12069049752359 0.0192148390700907 no 3266 0.0169739283576118 4682 9401657
SGTC_906 1165-0455 526 µM -2.12964694575361 0.0188101210537926 no 3267 0.0166003860780138 4695 3252859
SGTC_1036 k216-0215 33.5 µM -2.16871211814617 0.0171286309527452 no 3268 0.0150522733969208 4677 622330
SGTC_2584 androsterone 48.74 µM -2.17046395840766 0.0170563362324165 no 3269 0.0149858580667892 4623 2754130 A steroid.
SGTC_425 3825-7017 13.1 µM -2.17463588333409 0.0168852191824711 no 3270 0.0148287065513382 4701 3397440
SGTC_64 000l-0018 272.079 µM -2.17642194871887 0.0168124113395265 no 3271 0.0147618620329759 4635 6811119
SGTC_44 0929-0055 61.211 µM -2.1821868066703 0.0165792397552841 no 3272 0.0145478743053337 4568 1379590
SGTC_2389 9091542 195.52 µM -2.1897873268989 0.0162760551925003 no 3273 0.0142698321309313 4698 3626624 YOL127W RPL25
SGTC_936 3005-4620 401 µM -2.19201600847774 0.016188058555886 no 3274 0.014189175367395 4723 777207
SGTC_2763 lisinopril 49.32 µM -2.20392466826342 0.0157247372095012 no 3275 0.0137648211912243 4662 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_139 0099-0334 718.624 µM -2.22453116543593 0.0149498697523567 no 3276 0.0130563640367554 4711 97690
SGTC_1843 st055809 45.5 µM -2.2515299092641 0.0139844829539861 no 3277 0.0121759973675957 4744 16413835
SGTC_1510 1123-0200 71.5 µM -2.25641882353998 0.0138155423714934 no 3278 0.0120222069368092 4728 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1674 st016616 23.6 µM -2.27071817580467 0.0133314822421126 no 3279 0.0115820220034681 4724 625830
SGTC_2918 7977171 22.06 µM -2.28565336742458 0.0128416071558339 no 3280 0.0111372726976981 4723 2236483
SGTC_2751 anetholtrithion 17.25 µM -2.28967274125332 0.0127124605749908 no 3281 0.011020147363154 4694 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3293 9120939 62.045 µM -2.29309573373633 0.0126033639369282 no 3282 0.0109212469790424 4723 934087
SGTC_2746 daunorubicin 9.88 µM -2.30685277891658 0.0121730372280563 no 3283 0.0105315143826919 4765 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1089 terbinafine 2.25 µM -2.3132544138886 0.0119771715732773 no 3284 0.0103543277209104 4752 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2482 5981709 142.65 µM -2.33032696846082 0.0114681252982661 no 3285 0.00989443822256722 4718 877755
SGTC_3073 9114972 49.47 µM -2.33834992547084 0.0112354702492151 no 3286 0.00968455154715123 4743 41905075
SGTC_2770 toltrazuril 17.5 µM -2.34392334461004 0.0110762736550242 no 3287 0.00954104640217152 4711 68591 Kills coccidiodes.
SGTC_3 0833-0587 95.581 µM -2.36323618150108 0.010539711240236 no 3288 0.00905806003030635 4660 5382644
SGTC_2519 cryptotanshinone 88.04 µM -2.36529864802693 0.0104837713190994 no 3289 0.00900776833479914 4738 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_72 0744-0168 198.391 µM -2.3659899985746 0.0104650779262622 no 3290 0.00899096508973818 4689 677577
SGTC_506 n9-isopropylolomoucine 153 µM -2.38065022586696 0.0100754632843543 no 3291 0.00864105639306678 4750 6610355
SGTC_1115 galangin 695.678 nM -2.38457664155008 0.00997328722037074 no 3292 0.00854939297834844 4775 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_8 0354-0001 70 µM -2.38551036150597 0.00994912281817325 no 3293 0.00852772096013507 4746 4993152
SGTC_2116 5511452 16.8835 µM -2.39016194399276 0.00982950128100254 no 3294 0.00842047255148879 4762 870744
SGTC_1161 k007-0610 110 µM -2.40213462395604 0.00952736825653456 no 3295 0.00814985430308806 4698 5843850
SGTC_2184 6075246 200 µM -2.40305945426405 0.00950437143162636 no 3296 0.00812927191751817 4754 2267320
SGTC_3168 9103419 49.47 µM -2.42329702754749 0.00901315357973949 no 3297 0.00769017270540965 4773 16649256
SGTC_492 tmb-8 126 µM -2.42527358496237 0.00896639095936534 no 3298 0.00764842708402751 4781 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2621 lithochol-11-enic acid 100 µM -2.42958434693005 0.00886514091111014 no 3299 0.00755807360516054 4717 6708711
SGTC_2920 7982904 15.77 µM -2.43992130318414 0.00862642137625787 no 3300 0.00734523088581961 4735 6456808
SGTC_643 k048-0106 28.4 µM -2.46042502608917 0.00816954403909878 no 3301 0.00693862816566085 4779 6763920
SGTC_1824 st053723 68.6 µM -2.46503106624717 0.00806988281187481 no 3302 0.00685006863147919 4766 675225
SGTC_661 1304-0007 33.6 µM -2.47241786528285 0.00791228445778194 no 3303 0.00671012739744768 4768 3117130
SGTC_507 nimesulide 162 µM -2.47430056331071 0.00787255228255058 no 3304 0.0066748666466703 4766 4495 A COX2 inhibitor.
SGTC_2069 5228469 200 µM -2.52308619260075 0.00690238452913886 no 3305 0.00581649419453915 4748 2835210
SGTC_435 c-PAF 6.7 µM -2.52551626536914 0.00685694707420645 no 3306 0.00577642167011532 4700 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2927 9011802 47.9 µM -2.52590924799225 0.00684962396056834 no 3307 0.00576996434972391 4727 43912568
SGTC_1186 1319-0216 26 µM -2.52869754912652 0.00679786289244949 no 3308 0.00572433186922162 4780 4565136
SGTC_1571 st070080 73.4 µM -2.53680112892146 0.00664938703849077 no 3309 0.005593524226435 4744 4315245
SGTC_3181 9108277 49.47 µM -2.55043819162331 0.00640598903820496 no 3310 0.00537937996060947 4762 17097298
SGTC_577 r071-0003 38.6 µM -2.56566166544688 0.00614361898760318 no 3311 0.00514896102189567 4758 4568517 YMR134W ERG29
SGTC_1974 st069448 26.9 µM -2.56754213975038 0.00611187958717955 no 3312 0.00512111698189396 4762 6323587 YNR016C ACC1
SGTC_16 erodoxin 22.806 µM -2.61415441830438 0.00537020394332797 no 3313 0.00447242994816673 4791 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2749 bexarotene 57.39 µM -2.6177653667401 0.00531623553403685 no 3314 0.00442538199775703 4751 82146 An retinoic acid receptor inhibitor.
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -2.62367354863194 0.00522897289122707 no 3315 0.00434935578433321 4731 6708739 YPR165W RHO1
SGTC_198 3454-2873 16.191 µM -2.66232769957603 0.00468884279666298 no 3316 0.00388011439001397 4780 710957
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.66941553967072 0.00459538657427002 no 3317 0.00379916902381957 4764 3256 An antibiotic and ribosome inhibitor.
SGTC_2752 diclazuril 33.15 µM -2.67682926489612 0.00449941579412569 no 3318 0.00371612489213006 4717 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_893 0958-0369 48.9 µM -2.68323130228802 0.00441798570533175 no 3319 0.00364572706305205 4659 6819948
SGTC_796 1234-0020 70.7 µM -2.68662291602837 0.00437538210180728 no 3320 0.0036089193002511 4756 46495034
SGTC_2415 st077333 57.7 µM -2.71493214178724 0.00403385540184271 no 3321 0.00331446758795272 4757 2766255
SGTC_3173 9105693 49.47 µM -2.72531513648923 0.00391470445550013 no 3322 0.00321200696825711 4767 17096658
SGTC_1465 k213-0056 144 µM -2.72845710251709 0.00387927523690563 no 3323 0.00318156828831358 4736 24048857 YMR208W ERG12
SGTC_2126 5251174 33.877 µM -2.73554068776512 0.00380045178280351 no 3324 0.00311389432960847 4752 790722
SGTC_513 4245-1575 41.7 µM -2.75519861083022 0.00358917283935642 no 3325 0.00293282586667119 4670 719745
SGTC_3039 9090270 49.47 µM -2.7577647670995 0.0035623848602422 no 3326 0.00290990306618385 4776 17173750
SGTC_2741 miltefosine 3.04 µM -2.76298590452177 0.00350843508785468 no 3327 0.00286376199158004 4799 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3326 9140064 16.379 µM -2.77796962271684 0.00335765971749779 no 3328 0.0027349865878941 4768 1868434
SGTC_165 k038-0023 64.381 µM -2.80003939541027 0.00314617717618333 no 3329 0.00255481851516348 4761 46368543
SGTC_845 0330-0138 4.51 µM -2.81862501016531 0.00297746538160215 no 3330 0.0024114913178082 4772 9039800
SGTC_2163 5671233 125 µM -2.84803905663484 0.00272706967489872 no 3331 0.00219947628241113 4783 701023
SGTC_87 0100-0052 35.5 µM -2.84898115784856 0.00271937362069122 no 3332 0.00219297389418568 4784 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_368 fentichlor 4.58 µM -2.85617328420763 0.00266126411901922 no 3333 0.00214390523163527 4774 7329 A pesticide.
SGTC_3084 9116877 49.47 µM -2.88002226358725 0.00247651111538323 no 3334 0.00198823544904233 4769 27241325
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -2.91993690126916 0.002193100076789 no 3335 0.00175051132276047 4785 7104
SGTC_59 0330-0160 1.33 µM -2.93949446324129 0.00206525918085393 no 3336 0.00164374072129184 4753 4293482
SGTC_3096 9117468 49.47 µM -2.9575305582948 0.00195339714978814 no 3337 0.00155057004484832 4786 41316311
SGTC_2708 st078559 56 µM -3.02443937190026 0.00158485495951957 no 3338 0.00124547196025375 4794 17250902
SGTC_2938 9059746 27.26 µM -3.05404851395553 0.00144298225694261 no 3339 0.0011288778337554 4774 6471769
SGTC_2288 7946289 167.31 µM -3.06247544787752 0.00140477917531035 no 3340 0.00109757241253137 4781 1246052
SGTC_1855 st056195 39.6 µM -3.11514314097254 0.00118621005624352 no 3341 0.000919278329702965 4776 4028379
SGTC_3334 9142812 21.919 µM -3.13071092814182 0.00112784186472207 no 3342 0.000871918596756356 4784 45283678
SGTC_1015 4130-4525 82 µM -3.16348630432273 0.00101346569196348 no 3343 0.000779458432378052 4796 1363237
SGTC_1114 scopoletin 1.73284 µM -3.21685532978319 0.000849781733407383 yes 3344 0.00064801966740551 4804 5280460 A coumarin with genotoxic properties.
SGTC_3262 9137218 49.47 µM -3.27161421620145 0.000707414439514508 yes 3345 0.000534676923534735 4803 17650664
SGTC_426 0988-0037 14.6 µM -3.35690281475591 0.000528858210608414 yes 3346 0.000394104063652654 4783 5383008
SGTC_2602 kawain 100 µM -3.37076885240548 0.000504120701864099 yes 3347 0.00037479361868433 4791 5369129
SGTC_525 k781-2675 26.7 µM -3.4174053724222 0.000428563414296565 yes 3348 0.000316105337853546 4790 3651118 YDL195W SEC31
SGTC_1683 st010134 710 nM -3.44854407097161 0.000384115062292593 yes 3349 0.000281808743032587 4789 3818134
SGTC_1789 tunicamycin 25 nM -3.51111660765941 0.000307444613279321 yes 3350 0.000223114307040486 4789 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1820 st053765 18.6 µM -3.59727002203062 0.000224981008774435 yes 3351 0.000160787302479964 4804 3690829
SGTC_568 1193-0097 7.48 µM -3.74650752021475 0.000128939235304639 yes 3352 8.96568152024215e-05 4744 3646150
SGTC_2932 9016711 44.54 µM -4.57516834288778 4.06586871522409e-06 yes 3353 2.37918607293184e-06 4807 7117328
SGTC_453 enantio-paf c16 10 µM -4.70542595472289 2.23116093975325e-06 yes 3354 1.26668221948981e-06 4630 13871343 A lipid and platelet activating factor
SGTC_103 0844-0104 51.839 µM -5.10378362582279 3.23344417611198e-07 yes 3355 1.66464459483652e-07 4794 5375804
SGTC_310 1273-0058 1.06 µM -5.13542682957087 2.75627292344331e-07 yes 3356 1.40752195154559e-07 4716 2734232