SGTCid condition conc unit ATP12|YJL180C.score ATP12|YJL180C.strain.pval ATP12|YJL180C.strain.significant ATP12|YJL180C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_236 1509-0011 5.31 µM 18.3547261482314 3.91128838960828e-69 yes 1 1.51304441719008e-75 66 3107280
SGTC_1635 st007035 42.4 µM 17.1062894873357 2.41449909854031e-60 yes 2 6.66102091679363e-66 27 3716403
SGTC_275 trichlorophene 5.69 µM 11.9887711793579 1.01939154118392e-30 yes 3 2.03448244701744e-33 20 62616
SGTC_908 3448-7491 47.7 µM 11.9457636369941 1.63575945568885e-30 yes 4 3.41599724482796e-33 3 1203031
SGTC_2011 4012611 177 µM 8.61818394805819 8.09543480949819e-17 yes 5 3.40121704077711e-18 2 2049887
SGTC_514 4466-0038 2.65 nM 8.11081198189748 4.13320204291648e-15 yes 6 2.51413043974991e-16 37 5722064
SGTC_2326 6164455 177.58 µM 7.90044819522683 1.97278886333488e-14 yes 7 1.38951162511409e-15 1 2888790
SGTC_386 1509-0011 3.07 µM 7.30053216890363 1.36900774428089e-12 yes 8 1.43315875030151e-13 75 3107280
SGTC_995 3931-2021 34.6 µM 6.99092967561546 1.07655332662078e-11 yes 9 1.36535311507048e-12 5 730143
SGTC_1883 5-benzylidenerhodanine 20 µM 6.06257468316152 3.12835948340897e-09 yes 10 6.6979785205093e-10 19 1273210
SGTC_2310 7668677 200 µM 5.95642028719362 5.69902443974447e-09 yes 11 1.28911388234569e-09 5 2197143
SGTC_576 1073-0113 22.7 µM 5.9406439905317 6.22504570390207e-09 yes 12 1.41952281667323e-09 19 5439563
SGTC_310 1273-0058 1.06 µM 5.66008005428561 2.88423018270427e-08 yes 13 7.56511991937805e-09 153 2734232
SGTC_744 1594-0068 283 µM 5.61027244634451 3.75908813262227e-08 yes 14 1.01004167497069e-08 5 668392
SGTC_6 0844-0013 19.835 µM 4.99623831577733 8.23011244864377e-07 yes 15 2.92297052835248e-07 35 1584900
SGTC_1353 1498-1206 8.11 µM 4.97811923388831 8.96949628641198e-07 yes 16 3.21025508334436e-07 29 6756808
SGTC_607 4491-0986 66.8 µM 4.85087344235102 1.62790919836431e-06 yes 17 6.14594815915135e-07 12 698981 YDR232W HEM1
SGTC_880 0833-0487 87.2 µM 4.78845862130173 2.16945341602757e-06 yes 18 8.40336040212448e-07 6 76075
SGTC_2619 obliquin 87.91 µM 4.76785065761944 2.3834427416967e-06 yes 19 9.31008620349198e-07 104 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2370 9071495 200 µM 4.73853624418093 2.72295896481129e-06 yes 20 1.07633765076273e-06 12 21791103
SGTC_2349 9023730 187.07 µM 4.72617105037843 2.87964716748663e-06 yes 21 1.14396472275525e-06 8 4126287
SGTC_173 1273-0061 2.693 µM 4.56858226997039 5.80662191293551e-06 yes 22 2.45517163436112e-06 165 2847414 YPL266W DIM1
SGTC_1641 st009299 47.1 µM 4.54590834487768 6.41168114457353e-06 yes 23 2.73494185753184e-06 3 4046054
SGTC_917 harmaline 728.087 nM 4.53448472228099 6.73886586300991e-06 yes 24 2.88721406474566e-06 13 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_149 3970-0822 46.1 µM 4.43806329290773 1.02107714143346e-05 yes 25 4.53859650198933e-06 69 3114250 YBL034C STU1
SGTC_2630 antimycin a 100 µM 4.37613088748342 1.32776570265441e-05 yes 26 6.04022449754499e-06 27 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1073 triclabendazole 3.09 µM 4.37142501458579 1.35434438644169e-05 yes 27 6.17191220308631e-06 19 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_745 0469-0705 296 µM 4.34500742963423 1.51319535975238e-05 yes 28 6.96354746711139e-06 13 3486736
SGTC_2582 agaric acid 100 µM 4.2308172008095 2.42694892807171e-05 yes 29 1.16421920760879e-05 291 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_586 0957-0265 8.15 µM 4.10955916499692 3.95860320892007e-05 yes 30 1.98207571657772e-05 42 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1758 st042942 75.2445 µM 3.94172755040123 7.62971925954729e-05 yes 31 4.04484186201772e-05 22 669317
SGTC_1435 4092-0789 56.7 µM 3.78838577033712 0.000136030198423155 yes 32 7.58146403364791e-05 16 2248285
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 3.77316123553356 0.000143909087566113 yes 33 8.05960205471398e-05 98 16725076
SGTC_441 propafenone 146 µM 3.69408127842498 0.000192180581221133 yes 34 0.000110341605859871 7 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1063 disulfiram 1.84 µM 3.68366250233298 0.000199565771654618 yes 35 0.000114953300679257 32 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2016 5121758 140 µM 3.63594988133955 0.000236900020012823 yes 36 0.000138479090066768 68 2795203
SGTC_350 k064-0020 19.8 µM 3.51933970692891 0.000357293445277762 yes 37 0.000216311186416546 36 2790705
SGTC_1003 4049-0218 100 µM 3.4544835992276 0.000446779829524737 yes 38 0.000275673874665261 34 295161
SGTC_1374 2889-5571 141 µM 3.43328533467765 0.000480266233216668 yes 39 0.000298157095358188 66 2853281
SGTC_2177 5811945 192 µM 3.38848314607248 0.000558821625532112 yes 40 0.000351401739416951 43 5343475
SGTC_2218 6965428 192.983 µM 3.35996774198391 0.000614837651328806 yes 41 0.000389757868278399 15 675684
SGTC_455 paf C-16 10 µM 3.33880633407192 0.000659711220390886 yes 42 0.000420696009622724 49 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1797 st048695 56.8 µM 3.27592209265303 0.000811502946489793 yes 43 0.000526588042755024 99 592262 YIL048W NEO1
SGTC_918 glabranin 770.725 nM 3.27357496739653 0.000817746438032918 yes 44 0.00053098108198294 62 124049 Also referred to as licorice root.
SGTC_3208 9114115 49.47 µM 3.27133626348355 0.000823742682877762 yes 45 0.000535202761268538 66 650895
SGTC_168 3970-0862 530.542 µM 3.26070525814184 0.000852773357181738 yes 46 0.000555677486831749 183 3135186
SGTC_1145 3546-0597 10.2 µM 3.24528410227634 0.000896559826273942 yes 47 0.000586667494475051 46 875334
SGTC_2546 rhodinyl acetate 100 µM 3.2153098615177 0.000987633198990471 yes 48 0.000651518925571569 32 6708682
SGTC_525 k781-2675 26.7 µM 3.11375250079052 0.00136299786488246 no 49 0.000923621866889115 88 3651118 YDL195W SEC31
SGTC_2336 9001819 198.65 µM 3.11363067521847 0.00136351750725536 no 50 0.000924003274780276 91 2989602
SGTC_2696 st077691 74.316 µM 3.10911089970625 0.00138292483919908 no 51 0.000938256345508342 65 757133
SGTC_2294 7971431 200 µM 3.10810898951607 0.00138726093374904 no 52 0.000941443082741226 46 5741572
SGTC_852 0418-0143 439 µM 3.09536130566203 0.00144352539245713 no 53 0.000982866412765574 124 5369229
SGTC_1703 st026983 48.3 µM 3.07998409132695 0.00151416410582009 no 54 0.00103505826002709 46 1104023
SGTC_2176 5809774 33.9695 µM 3.07243314189685 0.00154999290266956 no 55 0.00106160695074294 42 2870539
SGTC_2759 disulfiram 3.38 µM 3.06744561643737 0.00157408054324851 no 56 0.00107948370937132 75 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_916 4466-0038 42 nM 3.01980506101173 0.00182196149994712 no 57 0.0012646871325488 144 5722064 YGL116W CDC20
SGTC_1819 st053448 58.6 µM 3.00988362954411 0.00187785229544249 no 58 0.00130673900531673 56 2857616
SGTC_2080 5212524 12.4 µM 2.98691902775518 0.00201324485032197 no 59 0.00140902175447871 47 260183
SGTC_1693 xanthone 101.9 µM 2.97818641933223 0.00206701355995505 no 60 0.00144979783193794 43 7020 An insecticide.
SGTC_2773 thioridazine 9.09 µM 2.96729483116089 0.00213590035784102 no 61 0.00150216358625564 46 5452 An antipsychotic.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.96417288709118 0.00215602628641672 no 62 0.00151748861192868 59 165521
SGTC_1539 benzyladenosine 56 µM 2.96002431787419 0.0021830365010694 no 63 0.00153807379941287 47 92208 A nucleotide analog.
SGTC_2835 9006588 71.43 µM 2.95676593237546 0.00220446563812695 no 64 0.00155442009241389 98 2345538
SGTC_1232 0279-0259 161 µM 2.95082190695329 0.00224404890222266 no 65 0.0015846479955381 74 1560000
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.92723726809158 0.00240753250660585 no 66 0.00170993935490099 77 6708561
SGTC_2250 alverine citrate 130 µM 2.90667588273001 0.00255877193550377 no 67 0.00182645738146847 272 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1870 st057514 26.5 µM 2.88837331746628 0.00270056455182533 no 68 0.0019361998901997 78 5393161
SGTC_2054 5233173 129 µM 2.86303576552504 0.00290856825862821 no 69 0.00209801598119558 133 6889
SGTC_1240 0356-0016 42.1 µM 2.84646908140973 0.0030522680413519 no 70 0.00221035109613428 81 4305613
SGTC_195 4234-0266 16.654 µM 2.83632592717201 0.00314337537169592 no 71 0.00228179240076385 94 2303354
SGTC_396 dithiazanine 1.25 µM 2.82918516857755 0.00320897531269238 no 72 0.00233333448735976 38 10578 An antihelmenthic.
SGTC_1238 0333-0287 48.8 µM 2.82865759174207 0.00321387051914644 no 73 0.00233718404396755 86 7226
SGTC_688 0527-0193 473 µM 2.81684378660122 0.00332526118247457 no 74 0.00242490539399058 49 4007154
SGTC_645 0845-0943 5.41 µM 2.80889796447529 0.00340212118683637 no 75 0.0024855699690055 59 1885106
SGTC_2345 9052315 157.45 µM 2.80260616098785 0.00346411038629017 no 76 0.00253457649706618 80 6469265
SGTC_2421 5690543 90.72 µM 2.79674402740489 0.00352277738070194 no 77 0.00258102061618271 77 3397993
SGTC_2930 9013230 14.89 µM 2.78741602797243 0.00361797092399273 no 78 0.00265651109285642 118 2995857
SGTC_676 falcarinol 140 µM 2.78341493539833 0.00365950538611818 no 79 0.00268949827342804 112 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_116 0155-0182 31.788 µM 2.73774890723219 0.00416476884962524 no 80 0.00309306437220745 189 771486
SGTC_2358 9037157 4 µM 2.73423053294236 0.0042061726063617 no 81 0.00312631252632282 96 2388925
SGTC_3189 9110682 49.47 µM 2.72241810506907 0.00434788577645223 no 82 0.00324030467793442 90 17122418
SGTC_3311 9131146 2.8755 µM 2.71928053459039 0.00438623731795019 no 83 0.00327120472259084 201 4900406 YPR165W RHO1
SGTC_354 2783-3500 4.88 µM 2.718444680607 0.00439650508948902 no 84 0.00327948112721693 134 6740761
SGTC_411 enrofloxacin 100 µM 2.68466001376019 0.00482992098122575 no 85 0.00363018098960281 61 71188 A bacterial gyrase inhibitor.
SGTC_100 0086-0128 49.5915 µM 2.67240406222225 0.00499632497304979 no 86 0.00376549527451848 136 93297
SGTC_3171 9103192 49.47 µM 2.64957161188321 0.00531999816428292 no 87 0.00402969450387596 42 13018434
SGTC_2727 riluzole 51.77 µM 2.63379223656961 0.00555445333825319 no 88 0.00422185689490004 65 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1036 k216-0215 33.5 µM 2.63366930300348 0.00555631539931995 no 89 0.00422338562391857 146 622330
SGTC_212 3807-4682 38.772 µM 2.60609714146538 0.00598822141151324 no 90 0.00457902422413831 185 3125501 YBL034C STU1
SGTC_650 1328-0195 38 µM 2.60152094559521 0.00606271624585554 no 91 0.00464056986813925 113 2780821
SGTC_978 1416-0512 87.4 µM 2.58859092928678 0.00627765840730881 no 92 0.00481847500789124 116 6814003
SGTC_2293 7624732 200 µM 2.57522601748122 0.00650689478769796 no 93 0.00500873014237866 107 894453
SGTC_1578 josamycin 24.2 µM 2.56538332083251 0.00668042125284833 no 94 0.00515309387759003 84 5282165 A P450 substrate.
SGTC_932 2857-0803 154 µM 2.56267196484596 0.00672893535216708 no 95 0.00519350675372474 102 674898
SGTC_2830 7992007 71.43 µM 2.56227980909719 0.00673597787740879 no 96 0.0051993751374206 100 1952075
SGTC_1723 st034307 2.5525 µM 2.55850682243656 0.00680406850543159 no 97 0.00525613786926203 115 867466
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.53880458499145 0.00716960227897718 no 98 0.00556159666251299 171 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_181 1447-1644 8.07 µM 2.53631077893865 0.00721708318375642 no 99 0.00560136331720406 117 534600
SGTC_670 4204-0025 119 µM 2.52870200401866 0.00736366884164983 no 100 0.00572425921886366 127 719039
SGTC_2083 5306046 65.942 µM 2.52527282356443 0.00743058664676924 no 101 0.00578042501645538 146 539837
SGTC_614 0462-0418 107 µM 2.51397414390426 0.007654878164605 no 102 0.00596895929130419 134 5188303
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.51155792277838 0.00770360929989481 no 103 0.0060099779179007 101 6708784 An antioxidant flavonoid
SGTC_1728 st035614 33.7865 µM 2.48685014448567 0.00821780931817467 no 104 0.0064439837107666 188 15945546
SGTC_1451 4152-0210 104 µM 2.48314576762764 0.00829744614341724 no 105 0.0065113892594444 136 659563
SGTC_3228 9131799 49.47 µM 2.48225257220151 0.00831674920055057 no 106 0.00652773503443324 76 17015818
SGTC_984 1492-0255 2.91 µM 2.47848254121167 0.00839865937700957 no 107 0.00659712841002252 116 1585198
SGTC_824 1304-0008 100 µM 2.45830466755303 0.00884920568388178 no 108 0.00697973462052493 147 768245
SGTC_2334 9017922 200 µM 2.45581954111233 0.00890613488451906 no 109 0.00702818617827497 105 3163164
SGTC_1949 st076024 69.1 µM 2.45250653433483 0.00898252807251783 no 110 0.00709324013988507 139 2921930
SGTC_2533 agelasine 13.65 µM 2.44723696667846 0.00910521950577152 no 111 0.00719780787627974 161 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_159 3970-0959 50 µM 2.42887655810258 0.00954424158326551 no 112 0.0075728440329024 276 6615653
SGTC_2756 carbadox 75.1 µM 2.41262858911735 0.00994807447176997 no 113 0.00791897478790845 204 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1741 st038134 10.228 µM 2.39106532150248 0.0105070021158211 no 114 0.00839978182954851 163 1272587
SGTC_778 3456-2434 196 µM 2.3908520788327 0.0105126633802034 no 115 0.00840466185548509 209 5539063
SGTC_568 1193-0097 7.48 µM 2.39003721531582 0.0105343212424956 no 116 0.00842333281644681 291 3646150
SGTC_2475 5812728 15.03 µM 2.38428966041209 0.0106881898191025 no 117 0.00855606362796806 141 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2067 5224629 34.075 µM 2.38189364054217 0.0107529097774084 no 118 0.00861193565985496 137 2835000
SGTC_3023 9089636 49.47 µM 2.38176466733167 0.0107564031872 no 119 0.00861495220179718 79 17249241
SGTC_233 rapamycin 362 pM 2.37849944142781 0.0108451759251942 no 120 0.00869163163066465 102 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2029 5175081 200 µM 2.36045329201276 0.0113473923257506 no 121 0.00912630834325552 153 1380876
SGTC_1547 harmine 94.2 µM 2.35224564222799 0.0115824151145435 no 122 0.00933022364867711 193 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2124 5246320 200 µM 2.34988701894708 0.0116507304199586 no 123 0.00938955509414124 147 579342
SGTC_3161 9100388 49.47 µM 2.34846894408608 0.011691971782005 no 124 0.00942538556777196 93 25236368
SGTC_3196 9111891 49.47 µM 2.34697474438291 0.0117355641040818 no 125 0.00946326881483825 110 18891510
SGTC_1740 st038286 13.222 µM 2.33784650492644 0.0120049499006731 no 126 0.0096976060846601 162 716786
SGTC_2371 9071574 200 µM 2.322820777164 0.0124600603993227 no 127 0.0100943912145958 103 45596039
SGTC_602 3130-1533 38.1 µM 2.31785613107465 0.012613681776929 no 128 0.010228570652241 162 720941
SGTC_2895 9054447 58.44 µM 2.31416259095047 0.0127290322127832 no 129 0.010329402567743 101 2697450
SGTC_695 3505-6186 243 µM 2.31263079131755 0.0127771379010177 no 130 0.0103714735531692 134 1819379
SGTC_11 0438-0307 1.3 µM 2.30523107991099 0.0130117448156674 no 131 0.0105768175476815 127 4011476
SGTC_3247 9135149 49.47 µM 2.30441201479143 0.0130379406759397 no 132 0.0105997630971903 116 8934436 YOR116C RPO31
SGTC_449 xestospongin c 11.1929 µM 2.29738725254465 0.0132644893658046 no 133 0.0107983441580344 207 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2676 harmalol 100 µM 2.2942634881047 0.013366318159502 no 134 0.0108876842408126 125 5459187 A monoamine oxidase inhibitor
SGTC_2264 7948757 110.76 µM 2.28969787781256 0.0135163625158638 no 135 0.0110194182633211 146 2971411
SGTC_2231 micatex 6.853 µM 2.28937962003246 0.0135268757455529 no 136 0.0110286526050117 107 20737 An antifungal of unknown mechanism.
SGTC_63 0099-0242 26.702 µM 2.27323971064317 0.0140693735446842 no 137 0.0115058692324102 255 3898502 YLR359W ADE13
SGTC_2607 solasodine 47.35 µM 2.26382967692899 0.0143942388163641 no 138 0.01179229624585 201 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3267 9137951 49.47 µM 2.26354817039162 0.0144040560293365 no 139 0.0118009593523762 80 16643986
SGTC_1427 4048-4900 550 nM 2.25873713483049 0.0145727285930125 no 140 0.011949870532074 147 24132586
SGTC_587 k089-0003 57 µM 2.25151105008309 0.0148292644869149 no 141 0.0121765939064416 72 9659696
SGTC_3239 9133757 49.47 µM 2.24294989835877 0.0151382145457568 no 142 0.0124500227560363 67 17036923
SGTC_3123 9126162 49.47 µM 2.23536182427812 0.0154166560344186 no 143 0.0126968021275242 145 25239884
SGTC_712 r015-0009 80.6 µM 2.23304368969915 0.0155025911624857 no 144 0.0127730316987562 133 6813872 YLR060W FRS1
SGTC_1696 st025591 34.7925 µM 2.23253374650585 0.0155215502448331 no 145 0.0127898537081836 179 2787147
SGTC_3301 9125354 19.7965 µM 2.23045341915143 0.0155991006761445 no 146 0.0128586782863235 132 41905162
SGTC_2279 7948423 32.93 µM 2.22972669264133 0.0156262698327434 no 147 0.0128827963464478 116 1247112
SGTC_1813 st051246 8.6015 µM 2.2240150072748 0.0158412220841866 no 148 0.0130737172789962 123 5291959
SGTC_3352 9151559 45.5865 µM 2.21209996776924 0.0162978030624708 no 149 0.013479879179365 149 17159339
SGTC_523 1934-0222 13.7 µM 2.21116950445665 0.0163339279061929 no 150 0.013512050653126 184 1361595
SGTC_1258 0671-0043 57.1 µM 2.20223923985963 0.0166841427673728 no 151 0.013824206800611 191 4298767
SGTC_2929 9013348 24.6 µM 2.20124682582738 0.0167234556736475 no 152 0.013859277493623 174 2995952
SGTC_1955 wogonin 32.4 µM 2.18754562300643 0.0172743581953688 no 153 0.0143513582389795 147 5281703 A flavanone.
SGTC_3256 9138902 49.47 µM 2.17471518063511 0.0178042317999294 no 154 0.0148257332921348 78 17228773
SGTC_3036 9090181 49.47 µM 2.17461296354123 0.0178085082343634 no 155 0.0148295660264852 115 25236586
SGTC_3102 9121669 49.47 µM 2.15719132530435 0.0185502896265074 no 156 0.0154953800482176 113 41905072
SGTC_2111 5486399 200 µM 2.15609987022303 0.0185976248561986 no 157 0.0155379338224767 230 689674
SGTC_134 0269-0018 6.916 µM 2.15599628604314 0.0186021225282196 no 158 0.0155419775803453 304 4378915
SGTC_1882 5615643 20 µM 2.14794798590045 0.0189544258617528 no 159 0.0158589438664856 161 2253075
SGTC_1884 5633444 25 µM 2.13496777202022 0.0195345703297318 no 160 0.0163818213523863 229 5724239
SGTC_3035 9091303 49.47 µM 2.13465990611463 0.0195485113415339 no 161 0.0163944001256766 117 25237002
SGTC_3097 9117246 49.47 µM 2.13282337499447 0.0196318501651056 no 162 0.0164696089886169 190 16423892
SGTC_673 1082-0474 110 µM 2.12930013959455 0.0197925735995712 no 163 0.0166147181339808 273 3098046
SGTC_1406 3909-7906 11.9 µM 2.12834791465658 0.0198362035580035 no 164 0.0166541240917491 172 X1406
SGTC_1909 st060837 51.5 µM 2.12495344674669 0.0199923992452487 no 165 0.0167952487921152 221 678937
SGTC_32 0928-0142 34.1 µM 2.12009958006425 0.0202175607492277 no 166 0.0169988241871828 122 2244242
SGTC_2151 5563267 85.4165 µM 2.11545094979387 0.0204352137399762 no 167 0.0171957656335489 202 5310824
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.11498066066375 0.020457343287755 no 168 0.0172157978184165 287 6708739 YPR165W RHO1
SGTC_800 3448-7362 155 µM 2.11420937795669 0.0204936801083705 no 169 0.0172486941282109 476 15991913
SGTC_1781 st038725 66.3 µM 2.11054525432553 0.0206670528986757 no 170 0.0174057087460111 307 4270275 YIL048W NEO1
SGTC_1133 3473-0247 50 µM 2.10995618755343 0.0206950409430951 no 171 0.0174310649138203 249 711311
SGTC_2339 9000433 200 µM 2.09824291644335 0.0212582681508134 no 172 0.0179418461337835 186 2988954
SGTC_98 0074-0023 107.663 µM 2.09603674564487 0.021365788900905 no 173 0.0180394657092647 229 3563821
SGTC_818 4072-2707 53.5 µM 2.08348539729877 0.0219862826861128 no 174 0.0186035006927355 168 882871
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.08176849195679 0.0220723317535275 no 175 0.0186818105206243 78 279621
SGTC_1708 st033234 31.827 µM 2.07149771691939 0.0225930472405136 no 176 0.0191561537948957 187 674664
SGTC_148 3253-0744 288.01 µM 2.06893814804619 0.0227244143694899 no 177 0.0192759456066603 194 6893655
SGTC_634 1611-4317 11.2 µM 2.06449782761464 0.0229538361044202 no 178 0.0194852698295704 212 2843522
SGTC_3206 9114350 49.47 µM 2.06061019241921 0.0231563006965441 no 179 0.01967012179664 185 17087243
SGTC_1802 st050112 57.9 µM 2.05429757553884 0.0234882582992084 no 180 0.0199734496308638 188 4662563
SGTC_1659 st012954 42.1 µM 2.0506714313469 0.023680748041294 no 181 0.0201494774534009 163 24207262
SGTC_637 1181-0519 7.26 µM 2.05024934825223 0.0237032397909845 no 182 0.0201700523102075 327 6252091 YGR060W ERG25
SGTC_2878 9043973 25.97 µM 2.049313927685 0.0237531500310384 no 183 0.0202157138075797 167 6465167
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.04686022777788 0.0238844895152059 no 184 0.0203359050618668 155 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2211 7117706 200 µM 2.03865233060287 0.0243282787189064 no 185 0.0207423692410391 173 822771
SGTC_2802 7925815 54.55 µM 2.03591117743508 0.0244780227033062 no 186 0.0208796376166321 242 1262923
SGTC_2284 7945075 39.21 µM 2.03457596174791 0.024551242739608 no 187 0.0209467790692944 234 1245402
SGTC_3 0833-0587 95.581 µM 2.03032436610942 0.0247856156240573 no 188 0.0211617895181415 186 5382644
SGTC_1150 3909-7983 10.9 µM 2.02439765663113 0.0251154596905264 no 189 0.0214646263426624 249 23965914
SGTC_3038 9091290 49.47 µM 2.00807406498529 0.0260430014564919 no 190 0.0223177108854631 211 25236843
SGTC_1323 1348-1351 11.2 µM 2.00706829040422 0.026101076723121 no 191 0.0223711960238862 179 6989654
SGTC_1295 1013-0063 9.78 µM 2.00465916703086 0.0262406244547866 no 192 0.0224997483159501 211 6826038
SGTC_2290 7904846 200 µM 2.00056998765666 0.0264789166769408 no 193 0.022719375299602 241 2962154
SGTC_3305 9127027 53.8275 µM 1.98846022889302 0.0271952278623742 no 194 0.0233804066852787 230 41905295
SGTC_2166 5933061 31.504 µM 1.9852207145255 0.027389568044364 no 195 0.0235599603150913 242 2877375
SGTC_2511 berberine 10.47 µM 1.98408638180846 0.0274578904479304 no 196 0.0236231055010318 191 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_841 0251-0215 91.2 µM 1.98322090690021 0.0275101147021508 no 197 0.0236713797876702 296 3888614
SGTC_2364 9055074 200 µM 1.98146247710961 0.0276164764708996 no 198 0.0237697166620533 220 6470630
SGTC_1044 1222-0021 1.78 µM 1.97365746048236 0.0280927224374183 no 199 0.0242103526467988 251 4306703
SGTC_3053 9095903 49.47 µM 1.95922321717484 0.0289914883984308 no 200 0.0250433256405558 166 17174018
SGTC_657 3534-0529 86.7 µM 1.94495485914806 0.029903283092162 no 201 0.0258902057532288 227 1049549
SGTC_2471 5466956 24.79 µM 1.94300630170041 0.0300296286145659 no 202 0.026007698460429 182 724419
SGTC_1254 0550-0035 264 µM 1.94024145186904 0.0302096623388043 no 203 0.0261751765127143 256 15121435
SGTC_539 4859-0462 2.54 µM 1.94019749845679 0.0302125315820545 no 204 0.0261778462122207 221 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2256 7954252 200 µM 1.93838543393107 0.0303310184524478 no 205 0.0262881080901989 169 2972920
SGTC_862 0452-0056 10.2 µM 1.93445651505647 0.0305892445926014 no 206 0.0265285118185858 211 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_150 3970-0969 77.2 µM 1.92516202113142 0.0312073748534202 no 207 0.0271045458950303 339 6615640
SGTC_2771 fluoxetine 41.05 µM 1.92379321020364 0.0312992744960507 no 208 0.027190254423605 215 3386 A selective serotonin reuptake inhibitor.
SGTC_59 0330-0160 1.33 µM 1.91662485145024 0.0317842079752172 no 209 0.0276428042460345 434 4293482
SGTC_810 3825-7150 143 µM 1.90730023521864 0.0324242824594273 no 210 0.0282408598859136 231 22330411 YGL099W LSG1
SGTC_2165 5727197 32.143 µM 1.90569446290046 0.032535574526836 no 211 0.0283449290579551 274 1361712
SGTC_1144 3486-0183 12.5 µM 1.89607910833228 0.0332086010152823 no 212 0.0289747923393863 278 6744069
SGTC_1986 st071812 45 µM 1.8956674081088 0.0332376720917436 no 213 0.0290020187982028 193 11838594
SGTC_3110 9122132 49.47 µM 1.89301056070082 0.0334257825510602 no 214 0.0291782325308184 224 918317
SGTC_309 k408-0051 1.48 µM 1.89240640662096 0.0334686800478454 no 215 0.0292184265443947 342 3640463
SGTC_1389 3405-0187 19 µM 1.89213671183144 0.0334878441463612 no 216 0.0292363840211064 239 799890
SGTC_2195 6536160 144.242 µM 1.89118446065429 0.0335555819284616 no 217 0.0292998624736933 210 3834386
SGTC_2477 5967686 25.23 µM 1.88421246453425 0.0340549734447627 no 218 0.0297681211010789 265 776118
SGTC_1182 1222-0449 220 µM 1.88349505458558 0.0341067052196225 no 219 0.0298166547068471 227 658318
SGTC_348 k064-0012 10.7 µM 1.8807924369436 0.0343021689964764 no 220 0.0300000796913418 217 5066323
SGTC_743 1275-0778 158 µM 1.87965678060522 0.0343845783242328 no 221 0.0300774347015238 283 2849257 YMR203W TOM40
SGTC_2428 5615643 7.78 µM 1.87413614212612 0.034787506373931 no 222 0.0304558314733937 259 2253075
SGTC_3172 9105863 49.47 µM 1.86958492820167 0.0351225884082157 no 223 0.0307707399257601 133 2348785
SGTC_1437 4092-1038 11.6 µM 1.86246506140052 0.0356520952516768 no 224 0.0312687828991469 263 3977136
SGTC_52 0329-0193 875 nM 1.86025001159426 0.0358181574732505 no 225 0.0314250811739193 271 3739292
SGTC_3286 9117135 37.221 µM 1.8584719518419 0.0359519166573948 no 226 0.0315510114239295 257 3438150
SGTC_392 N-ethylmaleimide 8.33 µM 1.855090325605 0.0362074373671218 no 227 0.0317916645395656 242 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1429 4049-0205 9.46 µM 1.85220231675413 0.0364268350137394 no 228 0.031998388119052 265 22774478
SGTC_611 3453-1652 23.7 µM 1.84617012579518 0.0368886013193881 no 229 0.0324337535986982 307 1560575
SGTC_3210 9128157 49.47 µM 1.84446815219309 0.037019750214869 no 230 0.0325574715259089 309 17590849
SGTC_2391 6285546 200 µM 1.84233383023282 0.0371847529517676 no 231 0.0327131670929033 305 846083
SGTC_1006 4099-6547 255 µM 1.84157870611662 0.0372432747251844 no 232 0.0327683990768479 270 3146833
SGTC_1381 2324-0066 62.1 µM 1.8251437166777 0.0385357293260502 no 233 0.0339896722991341 316 10885928
SGTC_2012 4023501 200 µM 1.82156860142418 0.0388216639782716 no 234 0.0342602343747788 267 3477460
SGTC_771 0250-0039 27.3 µM 1.81531925119008 0.0393256306286446 no 235 0.0347374311052333 264 3005115
SGTC_2079 5212404 121 µM 1.80992764597432 0.0397646920155585 no 236 0.0351535041300352 248 758462
SGTC_570 0987-0065 62.6 µM 1.80192955929812 0.0404233432349509 no 237 0.0357782444415994 192 3104428
SGTC_832 4083-0019 164 µM 1.79956581553646 0.040619687156934 no 238 0.0359646114425086 469 1990758
SGTC_351 caspofungin 25 nM 1.78858930174575 0.041541615491503 no 239 0.0368404910271464 434 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1652 st011932 78 µM 1.77798418811931 0.0424483810664268 no 240 0.0377032259249855 268 1551076
SGTC_3169 9102970 49.47 µM 1.77368751722968 0.0428202854039235 no 241 0.0380574261730413 222 17027839
SGTC_3324 9138759 60.749 µM 1.76745285857325 0.0433646135315248 no 242 0.0385762086312667 285 45595710
SGTC_1575 cyproterone acetate 48 µM 1.7655451076932 0.0435322849941389 no 243 0.0387360980969687 301 9880 An androgen receptor antagonist and liver toxin.
SGTC_365 0121-0052 13.6 µM 1.76521191559556 0.0435616227200806 no 244 0.0387640783783399 409 3101739
SGTC_2047 4141938 200 µM 1.76218328329686 0.043829027626107 no 245 0.0390191677784398 247 3807862
SGTC_3198 9112019 49.47 µM 1.75389186160791 0.0445678756508593 no 246 0.0397245191868892 280 45595555
SGTC_2652 actinonin 100 µM 1.74854578283152 0.0450495616131127 no 247 0.0401847825612204 226 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_856 0433-0016 11.3 µM 1.74660144823483 0.0452257833079907 no 248 0.0403532479140287 310 3911780
SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.73618580366472 0.0461792526280539 no 249 0.0412654932968918 338 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_276 colchicine 750 µM 1.73581668243299 0.0462133366844994 no 250 0.0412981267017176 336 2833 A microtubule depolymerizer.
SGTC_2561 acetosyringone 100 µM 1.73478951736342 0.0463082897793956 no 251 0.0413890467979874 367 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2762 leflunomide 42.06 µM 1.73372907750759 0.0464064831340121 no 252 0.0414830823538744 341 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_279 1273-0055 2.93 µM 1.73335044673792 0.046441583605284 no 253 0.0415166997250633 324 2847562
SGTC_830 4076-0286 57.8 µM 1.73142148247573 0.0466207366949234 no 254 0.0416883089077877 507 6866659
SGTC_3163 9099914 49.47 µM 1.73113541019867 0.0466473528950071 no 255 0.0417138080149963 197 16268368
SGTC_1682 st012968 530 nM 1.72318584357992 0.0473918709932401 no 256 0.0424274614545908 266 24207270
SGTC_3353 9151644 39.2805 µM 1.72195129268536 0.0475083425988403 no 257 0.0425391710818133 303 4909158
SGTC_482 fipronil 114 µM 1.72147365793298 0.0475534657135275 no 258 0.0425824541223903 206 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2677 mitomycin C 100 µM 1.72103385017088 0.0475950455905748 no 259 0.0426223407837731 244 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2142 5622915 118.518 µM 1.72062923413696 0.0476333241198446 no 260 0.0426590625415719 262 5322196
SGTC_2045 5106652 78.05 µM 1.71081408930845 0.0485694584401838 no 261 0.0435577189074717 294 673349
SGTC_2757 clomiphene 4.22 µM 1.70980651573241 0.0486663841000034 no 262 0.0436508288713787 367 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_988 1497-1057 103 µM 1.70752434268465 0.0488864942958669 no 263 0.0438623186074387 327 3533044
SGTC_214 4373-3496 70 µM 1.70601961554389 0.0490320563224349 no 264 0.0440022137572158 467 3779166
SGTC_3229 9132204 49.47 µM 1.70411491981943 0.0492168061921317 no 265 0.0441798098999612 223 17682924
SGTC_2912 7964298 10.93 µM 1.69718522450299 0.0498936609370261 no 266 0.0448308238328049 404 2975850
SGTC_2680 butyl paraben 22.24 µM 1.6954504082957 0.0500642650473344 no 267 0.0449950051466718 264 7184 An antifungal and steroid mimetic.
SGTC_1624 st003710 6.25 µM 1.69016927075735 0.0505864836014691 no 268 0.045497787739063 384 24207033
SGTC_808 0711-0032 135 µM 1.6872613635726 0.0508758753024184 no 269 0.0457765533512193 300 4252555
SGTC_2903 5923464 63.88 µM 1.68326531131511 0.0512757063829929 no 270 0.046161871228919 271 2876576
SGTC_1673 st016611 27.3 µM 1.67959569674454 0.0516450733402802 no 271 0.0465180027614323 367 5226799
SGTC_1724 st037281 8.293 µM 1.67839122802371 0.051766769821201 no 272 0.046635374471337 365 574124 YDL195W SEC31
SGTC_584 0986-0246 15.4 µM 1.67670297143602 0.0519377305284002 no 273 0.0468002896407406 353 53315 YDR232W HEM1
SGTC_2826 7992541 19.48 µM 1.67443505499832 0.0521680960615923 no 274 0.0470225640986695 334 2985066
SGTC_3079 9117512 49.47 µM 1.67278463292176 0.0523362486984363 no 275 0.0471848505601577 258 7185044
SGTC_3066 9117245 49.47 µM 1.67101354066992 0.0525171741780053 no 276 0.0473595016392613 325 17176980
SGTC_3099 9120367 49.47 µM 1.66876630887355 0.0527474537680065 no 277 0.0475818510546525 320 24824940
SGTC_2044 5102272 200 µM 1.6683667636469 0.0527884799460416 no 278 0.0476214709461482 281 592666
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.66768212198436 0.052858839302306 no 279 0.0476894231322092 332 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2216 7189485 200 µM 1.66693076796663 0.0529361401587654 no 280 0.0477640860126664 265 731273
SGTC_2455 5377712 9.75 µM 1.66630883499684 0.0530001937114255 no 281 0.04782595895935 304 2243908
SGTC_1317 1273-0028 910 nM 1.66627030355839 0.0530041641272857 no 282 0.0478297943661075 333 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_450 aminopyrene 156 nM 1.664044171667 0.0532339533971476 no 283 0.0480518012301129 370 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2580 diallyl disulphide 81.36 µM 1.66317392608695 0.0533239976624038 no 284 0.0481388126555201 331 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_102 gallobenzophenone 83.616 µM 1.66116679764013 0.0535321354273589 no 285 0.0483399759428282 371 70837
SGTC_2781 5567276 71.43 µM 1.66027488347982 0.0536248326045045 no 286 0.0484295830434672 360 2853274
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.65876170485166 0.0537823889768077 no 287 0.048581909951002 346 94937 An inhibitor of serotonin biosynthesis.
SGTC_2889 9059656 51.95 µM 1.65654325627528 0.0540140424758583 no 288 0.0488059263688529 354 3949838
SGTC_3227 9130768 49.47 µM 1.65407253235081 0.0542729678305545 no 289 0.0490563881329154 293 17720899
SGTC_2971 9092186 9.93 µM 1.65284763216873 0.0544016977590413 no 290 0.0491809386120994 322 25236400
SGTC_127 0180-0333 59.125 µM 1.64932895563467 0.0547728340745965 no 291 0.0495401303351278 454 771601
SGTC_2734 clemastine 41.6 µM 1.64636109922967 0.0550874255918251 no 292 0.0498447185353754 179 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1915 st067105 30.6 µM 1.64548639931899 0.0551804152695198 no 293 0.0499347725718448 378 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_530 4358-1714 28 µM 1.64417685768765 0.0553198648609943 no 294 0.0500698378901636 414 1564641
SGTC_1057 3448-5381 134 µM 1.64275225855545 0.0554718825201457 no 295 0.0502171007977198 366 5497911
SGTC_1134 3477-0009 42.5 µM 1.6387540957504 0.0559002848343156 no 296 0.0506322414298765 398 3973534
SGTC_1417 3966-0327 90.4 µM 1.63801668440296 0.0559795826481658 no 297 0.0507091066911798 376 651118
SGTC_3085 9117376 49.47 µM 1.63292553528563 0.056529484803427 no 298 0.051242329435581 353 16480349
SGTC_303 1348-1668 34.2 µM 1.62870622564794 0.056988436452805 no 299 0.051687612099578 313 5380509
SGTC_3263 9137018 49.47 µM 1.62417090726173 0.0574850279286475 no 300 0.0521696690387776 361 43844957
SGTC_141 0443-0274 32.331 µM 1.6237283922816 0.0575336625012084 no 301 0.0522168943292855 495 1627241
SGTC_2397 5161689 200 µM 1.62067624707272 0.0578699902533541 no 302 0.052543545186856 389 2259942
SGTC_1747 st037496 66.6 µM 1.61164122296947 0.0588746588128443 no 303 0.0535200173976823 398 723305
SGTC_3121 9125696 49.47 µM 1.60972350338905 0.0590896542598516 no 304 0.0537291157892339 293 1235365
SGTC_1419 3993-2473 62.6 µM 1.59960154885272 0.0602346457949723 no 305 0.0548435023233447 361 704026
SGTC_3046 9092212 49.47 µM 1.59688700664415 0.0605446484740712 no 306 0.055145448313515 327 25236637
SGTC_1588 farnesol 29.9 µM 1.5914438920589 0.0611700155866595 no 307 0.055754856524099 372 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3275 9138069 49.47 µM 1.58948548942198 0.0613962500615801 no 308 0.0559754137488221 337 17617007
SGTC_3296 9122258 64.045 µM 1.58925388796813 0.061423047800903 no 309 0.0560015423746839 387 4730474
SGTC_2974 9094440 9.66 µM 1.58763202250531 0.0616109638874971 no 310 0.056184786339984 430 25236134
SGTC_1628 st004252 77.7 µM 1.58317824394289 0.0621293065827408 no 311 0.056690421878176 393 692968
SGTC_1250 0485-0349 40.2 µM 1.57841742854946 0.0626871384701936 no 312 0.0572348719357361 395 6842794 YDL195W SEC31
SGTC_2822 7994718 71.43 µM 1.57720026651173 0.0628303798823477 no 313 0.0573747258500194 301 1018011
SGTC_2818 7996756 12.99 µM 1.57462731534317 0.0631340162637063 no 314 0.0576712470069502 275 2241621
SGTC_951 1171-0579 82.7 µM 1.56443932689919 0.0643475427301661 no 315 0.058857215572448 494 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3241 9133421 49.47 µM 1.56291808174755 0.0645302885358753 no 316 0.0590359320307611 277 17018221
SGTC_1218 1348-1416 30.7 µM 1.56155985511393 0.0646937915255053 no 317 0.0591958564721335 388 6787668
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.55055854053341 0.0660300081684187 no 318 0.0605037571210629 427 5106787 A p450 inhibitor.
SGTC_935 2996-0153 430 µM 1.54994230701091 0.0661054834796425 no 319 0.0605776819896046 370 23738523
SGTC_1441 4106-0040 13 µM 1.54869836255277 0.0662580434418554 no 320 0.0607271238512243 374 2904180
SGTC_1927 st060202 13.8 µM 1.54669527558454 0.0665042791194595 no 321 0.0609683714367304 371 688887
SGTC_2874 9043904 71.43 µM 1.54631786082312 0.0665507532106267 no 322 0.0610139102471179 306 4463428
SGTC_1954 st077032 68.9 µM 1.54566826909671 0.0666308014891125 no 323 0.0610923521503926 359 698907
SGTC_2751 anetholtrithion 17.25 µM 1.54330792639597 0.0669222906532996 no 324 0.0613780406759914 424 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_249 wiskostatin 11.211 µM 1.5428666594099 0.0669768939473209 no 325 0.0614315658659853 377 2775510 A n-wasp and actin depolymerizer.
SGTC_2197 6588183 93.1375 µM 1.54267634568382 0.0670004543969406 no 326 0.0614546619577297 324 884136
SGTC_3350 9150499 3.57 µM 1.53800273465049 0.0675810517300377 no 327 0.0620239730722837 461 4910996 YPR165W RHO1
SGTC_1574 spiramycin 23.7 µM 1.53516992839009 0.0679348556335094 no 328 0.0623710464620798 420 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1235 benzylparaben 21.5 µM 1.53228079527254 0.0682971659928368 no 329 0.0627265790707121 384 7180
SGTC_2816 7982706 58.44 µM 1.53031467031472 0.0685445783727462 no 330 0.0629694293620098 414 2981853
SGTC_662 k832-1615 104 µM 1.52835880239104 0.0687913854149431 no 331 0.0632117387998843 397 5878478
SGTC_353 1988-1175 58.3 µM 1.52771729520036 0.0688724849691011 no 332 0.0632913720518237 379 2788357
SGTC_2942 9052777 62.25 µM 1.52587256896366 0.0691061066216711 no 333 0.0635208016997436 451 6469503
SGTC_2943 9068529 45.32 µM 1.52334877859246 0.0694267156403449 no 334 0.0638357347668933 440 3270634
SGTC_73 0327-0325 16.231 µM 1.52143173864661 0.0696710109142187 no 335 0.0640757645949805 467 53298
SGTC_88 0180-0332 8.668 µM 1.51655241511812 0.0702957861571393 no 336 0.0646898636035381 414 3101745
SGTC_305 1682-2595 20.8 µM 1.50976078044683 0.0711725850122955 no 337 0.0655522379380182 410 226033
SGTC_1901 st060216 58.6 µM 1.50768957403975 0.0714416415050636 no 338 0.0658169975756394 420 688792
SGTC_95 0471-0001 561.058 µM 1.50531760205456 0.0717507265209401 no 339 0.066121220940194 434 4015405
SGTC_1920 st075728 45.7 µM 1.49611873835634 0.0729591135207818 no 340 0.067311357829788 411 3400306
SGTC_1229 0139-0193 12.2 µM 1.48832734826489 0.0739947434725848 no 341 0.0683322930132454 451 3090752
SGTC_2225 6654152 15.4 µM 1.48593742638287 0.0743146519755265 no 342 0.0686478364490645 336 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2817 7995342 71.43 µM 1.48226203360117 0.0748086897130298 no 343 0.0691352931289347 364 18879975
SGTC_182 3448-4371 550.524 µM 1.48085148928029 0.0749989557675553 no 344 0.0693230761774551 447 3491403
SGTC_1293 1000-1278 195 µM 1.47800437885946 0.0753841219588508 no 345 0.0697033030979674 443 678847
SGTC_2043 5101342 149 µM 1.47705986306171 0.0755122315622048 no 346 0.0698297956386358 443 678451
SGTC_2904 7225135 42.03 µM 1.4745884444805 0.0758482278979406 no 347 0.0701616117351615 440 4446116
SGTC_1368 1852-0141 284 µM 1.47241936169095 0.07614405794436 no 348 0.0704538339433314 438 2838987
SGTC_460 trequinsin 123 µM 1.465585969869 0.0770817717539451 no 349 0.071380557899649 433 5537 A vasodilator.
SGTC_3303 9125618 40.5795 µM 1.45995758516911 0.0778606978821525 no 350 0.0721508656456374 536 22695467
SGTC_1409 3909-8004 61.9 µM 1.45935150244014 0.0779449301641941 no 351 0.0722341934503614 456 2119279
SGTC_2765 myclobutanil 7.74 µM 1.45280835491011 0.0788586924567372 no 352 0.0731384857858256 456 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2855 9016525 58.44 µM 1.44709562376562 0.0796631015235553 no 353 0.0739350717710956 439 43811474
SGTC_1347 1493-0251 600 nM 1.44285706528371 0.08026393283516 no 354 0.0745303699808243 488 3986378
SGTC_1847 st056231 15 µM 1.44280126398775 0.08027186565221 no 355 0.0745382315054623 528 5393180
SGTC_3184 9108758 49.47 µM 1.43975156533969 0.0807063182150742 no 356 0.0749688493793547 414 902885
SGTC_1255 0566-0045 221 µM 1.43047020213678 0.0820394439885616 no 357 0.0762910560729507 488 2788469
SGTC_1318 1280-3875 124 µM 1.42645553696603 0.082621202928491 no 358 0.0768684462813737 492 373245
SGTC_3006 9075424 71.4286 µM 1.4233557659849 0.0830725060702998 no 359 0.0773165242848635 446 7465181
SGTC_3077 9117319 49.47 µM 1.4192175686468 0.0836778825605638 no 360 0.0779177977486708 393 17154678
SGTC_1857 st056007 79.3 µM 1.41800108699213 0.0838564703706405 no 361 0.0780952237092556 416 619834
SGTC_1526 st051518 75 µM 1.41729024350694 0.0839609594713141 no 362 0.0781990432434963 424 673993
SGTC_1462 k081-0014 26.5 µM 1.41460120747101 0.0843571138058259 no 363 0.0785927272911997 324 3270634
SGTC_2146 5545642 200 µM 1.41065106011574 0.0849415989056381 no 364 0.079173764024674 452 825326
SGTC_2387 9077560 195.08 µM 1.40968790899132 0.085084571206433 no 365 0.0793159282417597 477 5303272
SGTC_2126 5251174 33.877 µM 1.40802434040513 0.0853319396935602 no 366 0.0795619313362243 575 790722
SGTC_936 3005-4620 401 µM 1.40360010002309 0.0859924344072547 no 367 0.0802189826650027 531 777207
SGTC_210 3551-0445 56.827 µM 1.40298398510719 0.086084716819658 no 368 0.0803108073078031 484 2865180 YOR207C RET1
SGTC_2031 5180455 200 µM 1.39834174561358 0.086782420407071 no 369 0.0810052337748061 432 29949
SGTC_2159 5658611 73.75 µM 1.39817340840603 0.0868077997399971 no 370 0.0810304999991485 444 793844
SGTC_558 k064-0027 21.3 µM 1.39803997147583 0.0868279212780778 no 371 0.0810505321643644 477 5088526
SGTC_2811 7967822 32.47 µM 1.39750063231644 0.0869092860976736 no 372 0.0811315383227437 497 2232244
SGTC_3115 9123671 49.47 µM 1.39356369002405 0.0875049402367245 no 373 0.0817246998223988 450 3286988
SGTC_484 loperamide 105 µM 1.39040465543693 0.087985097018195 no 374 0.0822030167960911 363 3955 An opioid-receptor agonist.
SGTC_147 4466-0538 29.23 µM 1.38933502568361 0.0881481195892481 no 375 0.0823654489283692 514 6742687 YHR072W ERG7
SGTC_1839 st053978 48 µM 1.3883873970932 0.0882927359481829 no 376 0.0825095559764028 478 3788398
SGTC_2913 7966556 36.57 µM 1.38647867364084 0.0885845603838842 no 377 0.0828003939561346 444 2976516
SGTC_1464 k208-0027 110 µM 1.38560263801576 0.0887187376386795 no 378 0.0829341361344866 509 X1464
SGTC_1498 4478-3555 97.6 µM 1.38353984348338 0.0890352815208153 no 379 0.0832496995874872 411 3437919
SGTC_2925 9010536 32.5 µM 1.38225460350221 0.0892329312215589 no 380 0.0834467697657006 572 2994177
SGTC_1490 4089-0339 670 nM 1.38084750125916 0.0894496955853338 no 381 0.083662927330514 438 742542
SGTC_2992 9074591 71.4286 µM 1.3744117432668 0.0904461191519845 no 382 0.0846569462433467 471 17741321
SGTC_726 3448-4391 34.2 µM 1.37298172407458 0.0906686383282555 no 383 0.0848790141739168 536 1356692
SGTC_3135 9127742 49.47 µM 1.37192474437913 0.0908333713944558 no 384 0.0850434332226202 459 3643468
SGTC_2967 9089538 49.85 µM 1.36320610127202 0.0922006739767375 no 385 0.0864087824621299 542 728216
SGTC_694 1315-0438 43.2 µM 1.36110274963408 0.0925328019180626 no 386 0.0867406104263627 425 6793154
SGTC_2018 5133068 143 µM 1.35744552881161 0.0931123983169975 no 387 0.0873198450665453 494 785362
SGTC_480 am 92016 50 µM 1.35537199471916 0.0934422016056174 no 388 0.0876495337989807 456 2129 K+ channel blocker.
SGTC_1440 4100-1550 40 µM 1.35491824755795 0.0935144867013712 no 389 0.0877218025955706 446 742806
SGTC_2766 oltipraz 83.91 µM 1.35250284862876 0.0938999717910261 no 390 0.0881072540613527 510 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2057 5236571 38.335 µM 1.34823014325258 0.0945847433932109 no 391 0.0887921861821834 555 54684039 YBR257W POP4
SGTC_94 0334-0113 514.748 µM 1.34575763551618 0.0949826813238028 no 392 0.089190346048058 501 6795178
SGTC_1962 st076595 64.5 µM 1.34415908791055 0.0952406153056313 no 393 0.0894484741046201 515 279619
SGTC_1717 st033143 58.0435 µM 1.34340351997642 0.0953627094719983 no 394 0.0895706738650978 572 674616
SGTC_721 1187-1332 279 µM 1.34324379359386 0.0953885348164641 no 395 0.0895965226730663 415 25730
SGTC_1070 indatraline 8.81 µM 1.33920388347233 0.0960434401877724 no 396 0.0902521542699652 544 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2253 7938677 135.83 µM 1.33745547039931 0.0963278962980461 no 397 0.0905370041331378 500 2301972
SGTC_698 k064-0052 127 µM 1.33614212851941 0.0965419758682197 no 398 0.0907514111656125 452 5088751
SGTC_2990 9074105 71.4286 µM 1.33544409899252 0.0966558994108152 no 399 0.0908655198385097 471 6502001
SGTC_1960 st011366 51.8 µM 1.33419585697121 0.0968598677867762 no 400 0.0910698384891659 492 3972846
SGTC_2495 cafestol 54.53 µM 1.33353040995765 0.0969687338964032 no 401 0.091178901420514 485 16667697 An anti-infammatory.
SGTC_3005 9076496 71.4286 µM 1.33348721989187 0.096975802827828 no 402 0.0911859833691223 483 21368410
SGTC_2081 5214970 32.255 µM 1.33319449404953 0.0970237233279361 no 403 0.0912339928749067 502 2063512
SGTC_2028 5153890 36.43 µM 1.33212201103642 0.0971994419894009 no 404 0.0914100492588465 518 2830968 YPR165W RHO1
SGTC_2005 4024620 188 µM 1.33206221099077 0.097209246667871 no 405 0.0914198733062353 512 236743
SGTC_769 0302-0231 76 µM 1.33018013692232 0.0975181981810449 no 406 0.0917294634997301 624 571869 YER009W NTF2
SGTC_414 piperonyl butoxide 100 µM 1.32784229488862 0.0979029682722953 no 407 0.0921151056279048 513 5794 A potent inhibitor of cytochrome P450.
SGTC_1898 st060199 18.6 µM 1.32746533214883 0.0979651141257775 no 408 0.0921774002747181 492 688866
SGTC_332 4112-0506 40.9 µM 1.32444602935778 0.0984639179477634 no 409 0.0926774781020325 531 2790355
SGTC_2733 amorolfine 100 µM 1.32435119652599 0.0984796148683602 no 410 0.0926932174103902 399 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3057 9095946 49.47 µM 1.32373881073136 0.098581022312076 no 411 0.0927949020606436 523 24540043
SGTC_829 1635-0120 117 µM 1.32180493537043 0.0989017623968729 no 412 0.093116557239049 561 285054
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.31470260897577 0.10008625919965 no 413 0.0943049347078448 470 6857784
SGTC_969 1313-0238 134 µM 1.31207168388414 0.100527652786976 no 414 0.0947479744984858 590 5212874
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.31193291428475 0.100550973702788 no 415 0.0947713853920387 530 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_24 0417-1663 219 µM 1.30733221337879 0.101326380141973 no 416 0.0955499541536214 523 4329390
SGTC_2314 7727897 200 µM 1.30212816817998 0.102208715143526 no 417 0.0964362877053096 522 900724
SGTC_476 mead acid 10 µM 1.2971071404053 0.10306530479765 no 418 0.0972971625165552 473 5312531 An omega 9 fatty acid.
SGTC_1976 st070609 63.5 µM 1.29215753885877 0.103914800871771 no 419 0.0981512964960797 573 682556
SGTC_3015 9080845 49.47 µM 1.28982583422506 0.104316744356987 no 420 0.0985555680163034 569 5296973
SGTC_3067 9117431 49.47 µM 1.28941042579083 0.104388471310624 no 421 0.0986277193828977 493 17150885
SGTC_2217 6934799 96.0675 µM 1.28855948145606 0.104535512120962 no 422 0.0987756387186219 546 675606
SGTC_2790 5423970 71.43 µM 1.28835340237879 0.104571144569949 no 423 0.098811485774201 598 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_958 1222-0007 33 µM 1.28620106535847 0.104943823946708 no 424 0.0991864496807681 615 7312461
SGTC_1850 st056238 17 µM 1.28335123309145 0.105438753442385 no 425 0.0996845254577287 617 5393177
SGTC_1454 4239-0054 42.6 µM 1.28078982965755 0.105885030302876 no 426 0.100133748636962 613 1340767
SGTC_974 1326-0144 138 µM 1.27985718137676 0.106047865466299 no 427 0.100297684537936 575 5411856
SGTC_70 0141-0289 43.283 µM 1.27956771697641 0.106098441101957 no 428 0.100348604845447 788 352408
SGTC_2233 sulbentine 40.3845 µM 1.27954356257518 0.106102662181217 no 429 0.100352854750992 622 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_222 nsc-310342 10.666 µM 1.27682255768282 0.10657894572755 no 430 0.100832449863094 429 432556
SGTC_1392 3455-1037 33.9 µM 1.27454665834913 0.106978501915017 no 431 0.10123487398312 570 981132
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.27333297434209 0.107192017126555 no 432 0.101449955224619 549 689007
SGTC_2423 st077119 87.2 µM 1.27249103921746 0.10734031348318 no 433 0.101599352936734 568 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2325 6158266 200 µM 1.26880132282159 0.107991955287416 no 434 0.102255966612705 553 3623240
SGTC_3098 9119039 49.47 µM 1.26746226629737 0.108229149482283 no 435 0.10249502383488 573 17161528
SGTC_2451 5856223 45.7 µM 1.25912757350325 0.109713951309658 no 436 0.103992128204962 562 2179896
SGTC_534 k292-0788 63.4 µM 1.25809175945975 0.109899495320947 no 437 0.104179286594017 638 4146317
SGTC_3167 9103034 49.47 µM 1.25712819126167 0.110072300103726 no 438 0.104353610192115 488 5127859
SGTC_3145 9085516 49.47 µM 1.25400264943481 0.110634171250561 no 439 0.104920521218117 554 25236195
SGTC_1845 st056753 3.01 µM 1.25004880004923 0.111347886243228 no 440 0.105640860654351 597 5375839
SGTC_2568 diosmetin 100 µM 1.24722705570418 0.111859254711487 no 441 0.106157127538745 608 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_189 3970-0742 2.116 µM 1.24457043790409 0.112342231186396 no 442 0.10664484627256 566 2891807
SGTC_2442 5158906 48.48 µM 1.24026145265314 0.113128775407751 no 443 0.107439352569464 597 1893835
SGTC_486 niguldipine 82 µM 1.24023097159687 0.113134353253803 no 444 0.107444987932205 527 1236 A calcium channel blocker.
SGTC_472 calcifediol 10 µM 1.23975109085469 0.113222194347013 no 445 0.107533736759299 507 5283731 A vitamin D metabolite.
SGTC_1842 st055362 61.2 µM 1.23874702417241 0.11340614388694 no 446 0.107719599061851 640 676032
SGTC_893 0958-0369 48.9 µM 1.23843438726742 0.11346346386848 no 447 0.10777751835071 632 6819948
SGTC_3088 9117578 49.47 µM 1.23762790062022 0.113611423431244 no 448 0.107927032086305 568 678341
SGTC_2897 9048598 12.99 µM 1.23747675757959 0.113639167717172 no 449 0.107955068951576 565 6467404
SGTC_661 1304-0007 33.6 µM 1.23534378087729 0.114031218685692 no 450 0.108351293141014 576 3117130
SGTC_2275 7947463 200 µM 1.23505544220147 0.114084290508932 no 451 0.108404935453858 548 1225414
SGTC_2996 9066192 71.4286 µM 1.23499478245136 0.11409545782579 no 452 0.108416222981139 587 6472854
SGTC_46 0329-0187a 2.197 µM 1.23461531023143 0.114165335438 no 453 0.108486854120245 695 46494817
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.23430116352338 0.114223206793032 no 454 0.108545351268164 619 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1583 clindamycin 39.6 µM 1.23262068426214 0.114533135457789 no 455 0.108858658070315 553 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2473 5854593 8.94 µM 1.23246477706866 0.114561919536976 no 456 0.108887758169788 559 2872951
SGTC_791 1348-1292 225 µM 1.23241794171631 0.114570567433429 no 457 0.108896501087119 685 5437054
SGTC_2188 6126565 140.678 µM 1.22659034992897 0.115650228857803 no 458 0.109988299013466 547 874518
SGTC_901 1112-0062 60.1 µM 1.2243737802142 0.116062777785231 no 459 0.110405627867567 582 1908457
SGTC_520 3584-0023 682 µM 1.21755990927364 0.117337516455606 no 460 0.111695628588099 576 1340790
SGTC_1225 1216-0074 20.6 µM 1.21684831315738 0.117471211445587 no 461 0.111830967088539 600 4241466
SGTC_2987 9018338 71.43 µM 1.21587997208125 0.117653316991467 no 462 0.112015324255047 623 5055682
SGTC_301 4119-0100 24.5 µM 1.21412172991505 0.117984481393229 no 463 0.112350621626449 672 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3120 9124077 49.47 µM 1.21391516702286 0.11802343069563 no 464 0.112390060264609 626 18774327 YGL155W CDC43
SGTC_722 3534-0461 190 µM 1.20770593868649 0.119198485042893 no 465 0.113580196453249 608 658262
SGTC_3104 9120930 49.47 µM 1.20713801283955 0.119306371905715 no 466 0.113689498860393 544 17014836
SGTC_2665 lovastatin 100 µM 1.20697173785823 0.119337971612944 no 467 0.113721514152375 598 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1325 1431-0015 227 µM 1.20545300335074 0.119626872679955 no 468 0.114014235192854 593 1103340
SGTC_81 0411-0046 9.971 µM 1.20346154948381 0.120006443731616 no 469 0.114398881070728 565 12925265
SGTC_2525 harmine 47.85 µM 1.20270070444603 0.120151684651234 no 470 0.114546080611416 554 5280953 A monoamine oxidase inhibitor
SGTC_636 0kpi-0074 126 µM 1.20253244915249 0.120183820331953 no 471 0.114578650903342 584 616434
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.20208010302786 0.120270245562965 no 472 0.114666247218187 669 1377
SGTC_3317 9138495 8.753 µM 1.20133272777872 0.12041313496127 no 473 0.114811079981925 639 17020139
SGTC_1212 0520-0165 585 µM 1.2000235514715 0.120663722228672 no 474 0.115065096918995 617 5403258
SGTC_655 k060-0012 42 µM 1.19580125642234 0.12147440533537 no 475 0.115887062758048 617 5994525
SGTC_2347 9049783 174.81 µM 1.18881253419777 0.122824643297444 no 476 0.11725672229738 675 6467988 YPL169C MEX67
SGTC_45 0kpi-0036 14.9 µM 1.18868530320225 0.122849321795689 no 477 0.117281763029102 583 2795021
SGTC_3243 9134147 49.47 µM 1.1882417954181 0.122935374449912 no 478 0.117369080801397 656 24282180
SGTC_2715 st079500 56.4 µM 1.18778849424721 0.123023370953156 no 479 0.117458374258736 587 28246688
SGTC_257 daunorubicin 18.5 µM 1.18464136615512 0.123635520623915 no 480 0.118079637135041 605 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1143 3454-2408 5.08 µM 1.18143539714621 0.124261305364994 no 481 0.118714901603672 591 X1143
SGTC_1321 1326-2144 215 µM 1.18080618484009 0.124384383223393 no 482 0.118839863272538 606 3513030
SGTC_1105 epirubicin 18.1 µM 1.17917532213667 0.124703786906394 no 483 0.119164185269742 623 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1545 lovastatin 49.4 µM 1.17495092017087 0.125533798057252 no 484 0.120007175982502 670 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2139 5578692 56.4705 µM 1.17429288988321 0.12566343417868 no 485 0.120138865119696 579 650991 YMR113W FOL3
SGTC_1963 st076565 50.3 µM 1.17361347170067 0.125797381823895 no 486 0.12027494135151 631 4914280
SGTC_117 lucigenin 22.078 µM 1.16752782141519 0.127001612653671 no 487 0.121498639822506 690 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_237 nikkomycin 200 µM 1.16743588409875 0.127019866556507 no 488 0.121517193379651 669 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_836 0330-0104 1.35 µM 1.16733631920772 0.127039636952819 no 489 0.121537288477847 650 46494820
SGTC_1651 st011928 86.1 µM 1.16692275915374 0.127121779646489 no 490 0.121620781956263 646 720198
SGTC_1461 k072-0203 53.8 µM 1.16606023664175 0.127293215678501 no 491 0.121795045978799 622 5418714
SGTC_3051 9093778 49.47 µM 1.16361763354316 0.127779582847132 no 492 0.122289501043346 579 17217378
SGTC_1995 st072814 61.1 µM 1.16352139819991 0.127798771481981 no 493 0.122309010730931 630 5769371
SGTC_1485 3909-9022 254 µM 1.1634508050597 0.127812848519339 no 494 0.122323323391331 668 714516
SGTC_2687 chenodiol 100 µM 1.16183039711056 0.128136271715801 no 495 0.122652182079289 618 5702181 A cholesterol synthesis inhibitor.
SGTC_2459 5811157 9.22 µM 1.16086110149112 0.12833000848598 no 496 0.122849194967289 634 2870684 YBR192W RIM2
SGTC_2013 4024628 200 µM 1.1564893004354 0.129206343650158 no 497 0.123740536771889 587 5230760
SGTC_2008 4012253 172 µM 1.15635372287812 0.129233586566322 no 498 0.123768251111805 666 603940
SGTC_2635 hydroquinidine 100 µM 1.15634039462189 0.129236264957311 no 499 0.123770975866809 659 442912 An experimental heart treatment.
SGTC_1524 corynanthine 62.1 µM 1.15534305579292 0.129436795196456 no 500 0.123974985455187 636 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1233 0325-0408 14.2 µM 1.15329673183646 0.129848914692627 no 501 0.124394305553751 656 12874
SGTC_1029 k015-0030 64.7 µM 1.15155721455414 0.130199958545694 no 502 0.124751535782956 647 2208316
SGTC_483 fpl-64176 144 µM 1.15108481227679 0.13029540511964 no 503 0.124848672781381 608 3423
SGTC_540 1187-0821 17.3 µM 1.15095871778742 0.130320890078394 no 504 0.124874609701912 636 847520
SGTC_812 4251-0442 148 µM 1.15039720151703 0.130434420006704 no 505 0.124990156120071 644 5723007
SGTC_2961 9083290 32.55 µM 1.14832154522872 0.130854679384552 no 506 0.125417923997508 604 17741490
SGTC_3134 9127454 49.47 µM 1.14657880214554 0.131208255603618 no 507 0.125777870779155 663 24262820
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 1.14499396554455 0.131530367377789 no 508 0.126105828556003 687 688798
SGTC_553 k007-0256 45.7 µM 1.14476534599716 0.131576878407486 no 509 0.126153187041485 666 6287000
SGTC_2845 9003024 42.97 µM 1.14429868027501 0.13167185347918 no 510 0.126249895213518 679 2990173
SGTC_2408 sulbentine 18.36 µM 1.14379467849839 0.131774480251383 no 511 0.126354398640074 656 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1990 st072050 59.8 µM 1.14261858194332 0.132014176144311 no 512 0.126598493523092 688 17233948
SGTC_67 0335-0847 266 µM 1.14259326137834 0.132019339939453 no 513 0.126603752330283 812 4552207 YOR254C SEC63
SGTC_2775 cyproheptadine 69.59 µM 1.14169132123215 0.132203369590015 no 514 0.12679117477495 683 2913 A selective serotonin reuptake inhibitor.
SGTC_473 2-arachidonoylglycerol 10 µM 1.13832595159189 0.132891591974798 no 515 0.127492200684508 656 5282280 An endocannabinoid.
SGTC_1675 st018485 24.5 µM 1.13810384772778 0.132937099113533 no 516 0.127538560823533 679 3323024
SGTC_2086 5274770 176.623 µM 1.13790006802405 0.132978861228674 no 517 0.127581106437319 653 689278
SGTC_2379 9035213 200 µM 1.13658910847026 0.133247742023664 no 518 0.127855047639538 736 646551
SGTC_1881 5652484 16 µM 1.13539842205827 0.133492278500877 no 519 0.128104210266402 642 2255129
SGTC_596 1155-0152 116 µM 1.13416547898879 0.133745818507395 no 520 0.128362570735578 725 280313
SGTC_1051 3253-3903 78 µM 1.13298590536019 0.133988693396552 no 521 0.128610086154524 693 5509239
SGTC_648 0375-0473 33.3 µM 1.13186404098097 0.134219966942665 no 522 0.128845799287238 715 1713139
SGTC_2003 4023581 200 µM 1.13184538088772 0.134223816057721 no 523 0.128849722461616 651 16641307
SGTC_871 0574-0004 149 µM 1.13087211477133 0.134424681860395 no 524 0.129054460789699 725 9551173
SGTC_2805 7950783 58.44 µM 1.12905392982337 0.134800477421368 no 525 0.129437542109605 728 1178958 YDL195W SEC31
SGTC_385 1494-0393 12.4 µM 1.12791394211761 0.135036465607367 no 526 0.129678132591199 700 3090647
SGTC_896 0964-0007 44.5 µM 1.12739309323872 0.135144380471273 no 527 0.129788158974132 692 6756758
SGTC_740 k014-0057 261 µM 1.12425389883594 0.135796043388989 no 528 0.130452664896658 753 4012779
SGTC_1178 0988-0033 191 µM 1.12423270367546 0.135800450577379 no 529 0.130457159479429 704 5392207
SGTC_803 4488-1585 147 µM 1.12409794592187 0.13582847354853 no 530 0.130485738313515 684 747204
SGTC_1497 4476-2978 41.3 µM 1.12259230463457 0.136141842032077 no 531 0.13080534257488 743 1528379
SGTC_266 formosanin C 406 nM 1.12258758890116 0.136142824292351 no 532 0.130806344438439 704 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3022 9087993 49.47 µM 1.12217639167277 0.136228492972633 no 533 0.130893724207133 657 17173644
SGTC_3220 9131269 49.47 µM 1.1168654168663 0.137338294968219 no 534 0.132025936652492 682 17722206
SGTC_3062 9077494 49.47 µM 1.11423893300828 0.137889410742222 no 535 0.132588348555039 671 16459633
SGTC_1763 st044482 94.5 µM 1.11283544412372 0.138184522836366 no 536 0.132889554859634 710 88505
SGTC_2223 6903751 107.57 µM 1.11257840984849 0.138238616143343 no 537 0.132944768639503 644 5598863
SGTC_1874 staurosporine 7.6 µM 1.11246676157781 0.138262117211325 no 538 0.132968756831387 721 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_549 1661-1316 519 µM 1.11050718540652 0.138675035756451 no 539 0.133390266766514 718 2857282
SGTC_1765 st044815 90.4 µM 1.10608698454402 0.139609534958629 no 540 0.134344435815963 678 645695
SGTC_3140 9094243 49.47 µM 1.10565329776043 0.139701453237066 no 541 0.134438305704671 713 19291112
SGTC_2001 4023502 57.655 µM 1.10226665426219 0.140420654670284 no 542 0.135172880886621 703 108941 YCR052W RSC6
SGTC_1822 st052468 42 µM 1.09879209699894 0.141161134231842 no 543 0.135929380077241 667 2873678
SGTC_806 3966-4455 5.86 µM 1.09642139845226 0.141667882023864 no 544 0.136447201875647 626 714982
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.09619046705933 0.141717310461479 no 545 0.136497715282548 619 1241132 A phosphatase inhibitor.
SGTC_3031 9088762 49.47 µM 1.09441263305191 0.142098228248966 no 546 0.136887022892758 719 205253
SGTC_2023 5144124 124 µM 1.09300868565216 0.142399526566187 no 547 0.137194993115546 704 2830192
SGTC_7 0192-1582 4.227 µM 1.09074376789227 0.142886506372744 no 548 0.137692822983847 816 252616
SGTC_2051 5263410 176 µM 1.08973839031182 0.143103032814458 no 549 0.137914199981817 743 227584
SGTC_2179 6298986 200 µM 1.08441846871163 0.14425246379116 no 550 0.139089649321907 697 738374
SGTC_208 k072-0098 12.366 µM 1.08261321205119 0.144643920925554 no 551 0.13949007022718 804 5948901
SGTC_2877 9040724 71.43 µM 1.07965012418919 0.145287995422905 no 552 0.140149005880517 734 6463895
SGTC_1176 0848-0131 83.3 µM 1.07963585294938 0.145291102166677 no 553 0.140152184647198 779 6769040
SGTC_1755 st041960 45.185 µM 1.07742912373329 0.145772028674622 no 554 0.140644299456364 724 2257073
SGTC_2400 5203494 178.7 µM 1.0770584444068 0.145852918020389 no 555 0.140727078234208 669 6777674
SGTC_1341 1486-1360 280 µM 1.07670087836492 0.145930974374955 no 556 0.140806959922422 725 3976547
SGTC_2183 6420625 130.508 µM 1.07592882592124 0.146099608472183 no 557 0.140979544448069 783 2897619
SGTC_138 0850-0259 40.9225 µM 1.06853644971218 0.147720900541452 no 558 0.142639298815416 828 6813004
SGTC_1171 0368-0077 21.4 µM 1.06835475542282 0.147760900764298 no 559 0.142680258939499 702 3239779
SGTC_2313 7726885 200 µM 1.06754375763487 0.147939531364491 no 560 0.142863182614609 714 726423
SGTC_1756 st041558 35.5 µM 1.06688413860014 0.148084925797418 no 561 0.143012079066714 817 3955792
SGTC_1336 1486-0901 104 µM 1.06515030116381 0.148467557315419 no 562 0.143403959795273 735 5006114
SGTC_1315 1237-0019 3.69 µM 1.06227193482316 0.149104227592683 no 563 0.144056125716699 773 825140
SGTC_381 3461-2219 42.7 µM 1.06049585440423 0.149497990004197 no 564 0.144459537486263 777 2883159
SGTC_573 3702-0553 84.7 µM 1.06030468449433 0.149540414286188 no 565 0.144503004385638 719 1222756
SGTC_1268 0828-0275 2.46 µM 1.06022077050418 0.149559038952635 no 566 0.14452208695441 786 745337
SGTC_3288 9119690 36.221 µM 1.0591189247062 0.149803736661748 no 567 0.144772811129467 673 17595618 YKL019W RAM2
SGTC_2323 6148992 148.28 µM 1.05621276049022 0.150450417481316 no 568 0.14543551109234 678 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.05615550831615 0.150463175909918 no 569 0.145448586911 803 688801
SGTC_3050 9093513 49.47 µM 1.05452760998448 0.150826248456688 no 570 0.145820713344266 755 25236664
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.05433302433679 0.150869686170449 no 571 0.145865237071095 898 688664
SGTC_2931 9014674 55.67 µM 1.05309652839729 0.151145906018805 no 572 0.146148376897525 718 2996810
SGTC_2138 5575593 77.673 µM 1.04822745151603 0.152236874548184 no 573 0.147266912830951 721 762213
SGTC_3154 9100113 49.47 µM 1.0467730519071 0.152563759806267 no 574 0.147602130990107 731 25237525
SGTC_1567 st069303 68.4 µM 1.04433010290713 0.153113874965266 no 575 0.148166345002722 770 5581319
SGTC_304 1310-0298 97 µM 1.04401044141244 0.153185955048513 no 576 0.14824027940877 776 1550234
SGTC_691 1548-0686 185 µM 1.04274235256185 0.153472116376693 no 577 0.148533818412977 769 46495133
SGTC_424 splitomicin 100 mM 1.03889900738429 0.154341580422963 no 578 0.149425854047223 703 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_428 3448-4153 16.5 µM 1.03827635151688 0.154482747256351 no 579 0.149570707602799 673 3834874
SGTC_1288 0973-0013 65.5 µM 1.03724371935894 0.154717050883608 no 580 0.149811143818572 786 4315430
SGTC_782 0083-0095 30.5 µM 1.03707982218979 0.154754260634693 no 581 0.149849329034048 809 3591729 An indicator and reagent.
SGTC_1074 carmofur 3.8 µM 1.03548617225765 0.155116376925188 no 582 0.150220960421366 836 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_129 0088-0017 176.636 µM 1.03460802224399 0.155316152984438 no 583 0.150426003000313 736 182446
SGTC_1519 esterone 74 µM 1.03371173942848 0.155520229217955 no 584 0.150635471662645 763 698 A steroid.
SGTC_1552 6-methylflavone 10.6 µM 1.03300671869887 0.155680880891377 no 585 0.150800377235792 734 689013
SGTC_551 k048-0028 34.9 µM 1.03291705956641 0.155701319181298 no 586 0.150821357273441 822 6836383
SGTC_2109 5483026 200 µM 1.03260521340185 0.155772420001062 no 587 0.150894343714753 788 759335
SGTC_48 0382-0018 55 µM 1.03259208524406 0.155775413686124 no 588 0.15089741682714 733 762596
SGTC_3019 9081971 49.47 µM 1.03176706739791 0.155963623085737 no 589 0.151090625178541 807 16451803
SGTC_1050 3232-1156 69.3 µM 1.02811909040965 0.156797623485828 no 590 0.15194690581671 746 700529
SGTC_143 4032-1194 15.74 µM 1.02654004550971 0.157159533130585 no 591 0.152318548885617 851 1806963
SGTC_58 0957-0393 9 µM 1.02647587401738 0.157174252540398 no 592 0.152333664998278 929 6997992
SGTC_687 k029-0044 34.9 µM 1.02015340391251 0.158628920964732 no 593 0.153827856249497 844 5829338
SGTC_1509 1326-1131 80 µM 1.01971047485197 0.158731159538681 no 594 0.153932896173831 755 768313
SGTC_330 1488-0319 80.1 µM 1.01671961916775 0.159422650686329 no 595 0.154643414930879 781 6846614
SGTC_2178 5812956 200 µM 1.01576081056862 0.159644745776994 no 596 0.154871651083957 768 5403383
SGTC_2627 acetyl isogambogic acid 100 µM 1.0151865281133 0.159777867477931 no 597 0.15500846058275 729 6857789 A caspase activator and apoptosis inducer.
SGTC_708 3448-5400 146 µM 1.01456174628253 0.159922777659885 no 598 0.155157391004407 782 3462195
SGTC_730 1436-0052 41.2 µM 1.01382061367667 0.160094785347134 no 599 0.155334178630083 751 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2342 7990637 118.86 µM 1.01304833819838 0.160274149553713 no 600 0.155518536363324 797 2033102 YER133W GLC7
SGTC_331 k048-0133 24.5 µM 1.01287934639536 0.160313416114182 no 601 0.15555889735657 736 6813582
SGTC_448 monastrol 171 µM 1.01171594620795 0.160583911816358 no 602 0.155836944421704 793 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2785 7756463 72.73 µM 1.01076619858494 0.160804953247298 no 603 0.156064172327407 775 2201551
SGTC_1686 st019653 115.5 µM 1.00945694894253 0.161109989630363 no 604 0.156377769173887 801 97252
SGTC_2560 caryophyllene 100 µM 1.0068525417594 0.161717900957762 no 605 0.157002820542143 871 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2656 pseudo-anisatin 100 µM 1.00667822222218 0.161758643305369 no 606 0.157044715405876 803 6708809 A neurotoxin.
SGTC_3279 9140807 49.47 µM 1.00477241762276 0.162204508454109 no 607 0.157503224130098 801 45595718
SGTC_2852 9023854 51.95 µM 1.00450862946983 0.162266284975342 no 608 0.157566756942681 802 19798528
SGTC_1305 1181-0477 144 µM 0.999801101168532 0.163371315861638 no 609 0.158703386412084 796 6252086
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.996575702047071 0.164131251650107 no 610 0.159485252437476 753 17037758
SGTC_2194 5927483 104.545 µM 0.988706254459696 0.165994975897009 no 611 0.161403440917861 858 760979
SGTC_983 1491-0821 12.2 µM 0.987676126065073 0.166239949922178 no 612 0.16165564516908 836 46495113
SGTC_592 k241-0073 46.5 µM 0.986484128172375 0.166523709281183 no 613 0.161947800015115 880 4230158
SGTC_1377 2944-0135 198 µM 0.980810787154073 0.16787855080154 no 614 0.163343028864925 844 1894137
SGTC_3074 9116018 49.47 µM 0.980658455825415 0.167915026359396 no 615 0.163380598615109 784 17027303
SGTC_186 3455-3465 67.277 µM 0.980544443611399 0.167942329787967 no 616 0.163408721325484 756 755278
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.980394102703124 0.167978337511613 no 617 0.163445809823913 808 5379071
SGTC_3268 9137683 49.47 µM 0.979119558820379 0.168283799500144 no 618 0.163760454312855 805 1953228
SGTC_3092 9117248 49.47 µM 0.978715677795382 0.168380669651149 no 619 0.163860241716244 886 17141857
SGTC_1914 st062367 72.6 µM 0.978310529584258 0.168477879756999 no 620 0.163960381843032 779 978205
SGTC_1788 fluconazole 20 µM 0.977694539148768 0.168625747870113 no 621 0.164112711721771 777 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2732 terfenadine 20 µM 0.976935953741178 0.168807960402077 no 622 0.164300430374401 786 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2087 5276107 200 µM 0.976899995462452 0.168816600735152 no 623 0.164309332022545 820 144405
SGTC_1237 0330-0133 46.1 µM 0.973492236327432 0.169636732840666 no 624 0.165154358465215 799 X1237 YHR072W ERG7
SGTC_3122 9126309 49.47 µM 0.971293710508777 0.170167197518443 no 625 0.165701019943282 876 17591206
SGTC_2484 5809818 12.04 µM 0.969951086730311 0.170491670649273 no 626 0.166035436892105 805 2870548
SGTC_2307 7538926 6.34 µM 0.968904467872327 0.170744882612237 no 627 0.166296428034209 828 96582
SGTC_2145 5634607 200 µM 0.966475513974101 0.171333454412273 no 628 0.166903146845866 780 308662
SGTC_2403 6032726 181.2 µM 0.964862243437333 0.171725089874196 no 629 0.167306907416213 797 2881040
SGTC_2591 skatole 100 µM 0.964817137949766 0.171736047834712 no 630 0.167318205211135 818 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_956 1185-0240 191 µM 0.964578487890951 0.171794033089392 no 631 0.167377989256259 812 1416193
SGTC_312 4092-0653 6.84 µM 0.963372719250611 0.172087192123365 no 632 0.16768025588326 912 1148278
SGTC_3070 9117005 49.47 µM 0.960817857196847 0.172709411175522 no 633 0.168321879128006 803 8779016
SGTC_1183 1254-0324 198 µM 0.959011220113228 0.173150269730334 no 634 0.168776546420688 846 5799357
SGTC_2356 9061756 188.97 µM 0.955750900488485 0.173947670302042 no 635 0.169599049886588 854 20104043
SGTC_638 3970-0837 4.09 µM 0.955314924666573 0.174054476866456 no 636 0.16970923113031 831 4118451 YLR208W SEC13
SGTC_22 0964-0034 14.468 µM 0.95451395928725 0.174250808212345 no 637 0.169911773357271 872 138402
SGTC_770 0389-1121 67.2 µM 0.95355882842683 0.174485112241446 no 638 0.170153502317803 894 6753108
SGTC_2464 5717415 7.67 µM 0.952577243141705 0.17472611422505 no 639 0.17040215598296 844 5285744
SGTC_2940 9060638 45.86 µM 0.949889192310134 0.175387174239624 no 640 0.17108427948734 826 4027022
SGTC_955 1216-0110 33 µM 0.948386128103741 0.175757506197053 no 641 0.171466459378152 836 3619719
SGTC_1017 4239-0030 168 µM 0.948320361794257 0.175773721310004 no 642 0.171483194041561 843 1149593
SGTC_3274 9138298 49.47 µM 0.947794851748274 0.175903323280312 no 643 0.171616950966528 909 17015756
SGTC_2698 st077697 67.5 µM 0.946276821482062 0.176278041667318 no 644 0.172003706158873 806 3154499
SGTC_857 0438-0306 1.35 µM 0.944652579186648 0.176679536921655 no 645 0.172418137124278 866 4686136
SGTC_3221 9128209 49.47 µM 0.94383515212546 0.176881814652874 no 646 0.172626947156494 816 16460723
SGTC_2836 9010338 19.48 µM 0.941598139137521 0.17743612629913 no 647 0.173199211414406 806 2994051
SGTC_2556 citropten 84.59 µM 0.941521314224019 0.177455182276448 no 648 0.173218885908669 935 2775 A potential DNA crosslinker.
SGTC_2801 7907800 81.82 µM 0.938104337794249 0.178304049910551 no 649 0.174095396414312 868 6620925
SGTC_2337 9009472 200 µM 0.936700701536959 0.178653490620311 no 650 0.174456267643886 872 5742383
SGTC_2962 9082311 13.18 µM 0.929373393141553 0.180484646550648 no 651 0.176347805835247 820 16459453
SGTC_635 k038-0028 24.7 µM 0.928191932989033 0.180781001786641 no 652 0.176654009120134 889 4035102
SGTC_781 4335-2806 94.4 µM 0.927906696012706 0.180852595780645 no 653 0.176727985365411 961 845254
SGTC_1817 st052116 64.4 µM 0.926554695842674 0.181192187217349 no 654 0.177078893146409 862 4361398
SGTC_3185 9108267 49.47 µM 0.925755650396037 0.181393076759992 no 655 0.177286489914708 869 4910486
SGTC_2719 novobiocin 32.65 µM 0.92511776235492 0.181553549466494 no 656 0.177452327299644 838 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1186 1319-0216 26 µM 0.924847391284836 0.181621593185614 no 657 0.177522647593469 929 4565136
SGTC_307 1501-1223 22.3 µM 0.923414718408091 0.181982417229884 no 658 0.177895562206592 862 2830329
SGTC_1646 st011709 75.6 µM 0.922045001807995 0.182327804321405 no 659 0.178252551358317 850 5757843
SGTC_2712 st079126 47.7 µM 0.920245430667526 0.182782205454754 no 660 0.178722259183032 842 3152970
SGTC_1904 st060225 78 µM 0.919430257175675 0.182988273471668 no 661 0.178935284623417 877 66595
SGTC_2722 naftopidil 47.16 µM 0.918387012279226 0.183252207126378 no 662 0.179208143887952 919 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_108 0509-0257 621.132 µM 0.917216155284193 0.183548708335453 no 663 0.179514691418406 913 536624
SGTC_766 1391-0721 126 µM 0.914101655168162 0.184338861111652 no 664 0.180331716446133 915 1020919 YIL115C NUP159
SGTC_3109 9122853 49.47 µM 0.912809732576145 0.184667243669062 no 665 0.180671309354596 963 1234709
SGTC_1281 0884-0031 11.8 µM 0.909998968623026 0.185382942786558 no 666 0.1814115268537 902 1548255
SGTC_1648 st011736 69.8 µM 0.90944449963665 0.185524329181939 no 667 0.181557770716614 883 2855514
SGTC_2399 5884133 200 µM 0.909207810577188 0.185584703903479 no 668 0.181620221059838 866 722445
SGTC_1108 betulinic acid 729.144 nM 0.908654137662413 0.185725982580202 no 669 0.181766359999772 900 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1357 1503-1303 39.5 µM 0.908227532317544 0.185834883388978 no 670 0.181879010310484 922 292895
SGTC_2721 ifenprodil 61.44 µM 0.905968103206957 0.18641231463152 no 671 0.182476367748596 881 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1195 1502-0147 41.1 µM 0.904840745022559 0.186700843211429 no 672 0.182774881248109 942 817940
SGTC_2728 chlorpromazine 9.18 µM 0.904283542285922 0.186843552019839 no 673 0.182922535629494 832 2726 A thorazine and dopamine antagonist.
SGTC_2842 9000675 19.48 µM 0.903597135691688 0.18701944484217 no 674 0.183104530326641 843 2989072
SGTC_1615 st002656 86.5 µM 0.903366636136997 0.187078533700969 no 675 0.183165670590848 885 1584458
SGTC_251 melphalan 456.522 µM 0.902570520055282 0.187282707894938 no 676 0.183376939197655 997 460612 A DNA alkylator.
SGTC_1265 0819-1001 68.8 µM 0.902205285100472 0.187376423174433 no 677 0.183473913921022 869 3106768
SGTC_1923 st058458 19.1 µM 0.901804211911184 0.187479367539744 no 678 0.183580440988754 972 3534982
SGTC_794 k038-0031 316 µM 0.900716144696368 0.187758820213826 no 679 0.183869631218755 961 6624242
SGTC_3254 9136651 49.47 µM 0.900453761135461 0.187826247720385 no 680 0.183939410856452 962 16454030
SGTC_418 lividomycin a 100 µM 0.897908781346091 0.188481034074441 no 681 0.184617091346664 972 72394 An antibiotic.
SGTC_1038 k292-0204 154 µM 0.894451523133193 0.189372788317496 no 682 0.185540177957217 844 4454212
SGTC_380 3970-0968 6 µM 0.892636990739814 0.18984186047991 no 683 0.186025801562247 880 2891601
SGTC_2091 4-phenylthiadiazole 200 µM 0.885667246904806 0.19165023202257 no 684 0.18789843139263 928 270010
SGTC_1957 st077035 62.4 µM 0.885496926345128 0.19169455509244 no 685 0.187944338316709 960 705593
SGTC_1965 Pectolinarigenin 58.4 µM 0.884330760340237 0.191998198848843 no 686 0.188258843931002 945 5320438 An anti-inflammatory.
SGTC_3193 9111931 49.47 µM 0.881851287585149 0.19264477609242 no 687 0.188928616194852 925 17087244
SGTC_338 4055-0136 114 µM 0.88011713897684 0.193097783450828 no 688 0.189397927683544 938 2900563
SGTC_1940 st075990 51.1 µM 0.879826089066486 0.19317387738749 no 689 0.189476764587455 980 1084979
SGTC_1455 4262-0120 131 µM 0.877161861393914 0.193871280343767 no 690 0.190199364037559 971 1529587
SGTC_3222 9128301 49.47 µM 0.876961407724799 0.193923814204216 no 691 0.190253800056863 938 4911358
SGTC_3272 9137413 49.47 µM 0.876692008528887 0.19399443061428 no 692 0.190326974279361 942 17614870
SGTC_1123 mangostin 811.285 nM 0.875510284904236 0.194304375626734 no 693 0.190648158287884 876 5281650 An antioxidant.
SGTC_335 4077-0256 27.6 µM 0.873126175584896 0.194930602092848 no 694 0.191297153999951 1023 3121989
SGTC_850 0388-0143 75.9 µM 0.872506133482979 0.195093667467064 no 695 0.191466161792771 894 67273
SGTC_1371 2421-0008 32.7 µM 0.872159402827728 0.195184890580032 no 696 0.191560711670819 905 2827552
SGTC_1838 st055369 84.5 µM 0.864738944766769 0.197143384586396 no 697 0.193591044444795 978 676036
SGTC_112 phenothiazine 287.218 µM 0.863634954429632 0.197435775428918 no 698 0.19389422799132 997 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1397 3532-0190 20.1 µM 0.860767708916876 0.198196386815219 no 699 0.194682996521731 907 5322280
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.856179108417532 0.199417306692228 no 700 0.195949358258339 941 390807
SGTC_3273 9137859 49.47 µM 0.854551448183708 0.199851474839071 no 701 0.196399757944809 979 2377234
SGTC_3027 9089541 49.47 µM 0.853849810837112 0.200038807419529 no 702 0.19659410563526 959 9943819
SGTC_767 0929-0023 86 µM 0.853179453377879 0.200217887050871 no 703 0.196779897852833 1018 1204563
SGTC_594 1487-1584 10.8 µM 0.851580922129221 0.200645308100054 no 704 0.197223365993266 989 5013332
SGTC_3323 9138564 53.9225 µM 0.848550593669706 0.20145707027285 no 705 0.198065704330641 1055 43912313 YNL103W MET4
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.846778689252948 0.201932637236909 no 706 0.198559244349062 925 279621
SGTC_2407 paclitaxel 400 µM 0.846386531303449 0.202037980489695 no 707 0.198668574815525 976 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2703 st077852 53.4 µM 0.845252675765136 0.202342746889272 no 708 0.198984888734705 936 6281836
SGTC_2420 aureobasidin a 50 nM 0.844387074534794 0.202575594798409 no 709 0.199226571378583 1001 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2205 7238770 200 µM 0.844344546320968 0.202587039072253 no 710 0.199238450143749 986 279867
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.844335936433445 0.202589356026156 no 711 0.19924085506582 1047 1273210
SGTC_1625 st003711 30.1 µM 0.843940497045192 0.202695787357514 no 712 0.199351328416597 985 24207034 YER133W GLC7
SGTC_927 2425-1185 123 µM 0.843807799036051 0.202731510116968 no 713 0.199388408337822 963 730375
SGTC_773 4358-1457 44.6 µM 0.843418311848964 0.20283638312762 no 714 0.199497267062783 1025 1186886
SGTC_234 nsc-17383 10.7 µM 0.843206070472267 0.202893544711691 no 715 0.199556601978858 1034 408974
SGTC_3187 9109394 49.47 µM 0.842632948466518 0.203047947983836 no 716 0.199716878956953 980 17098090
SGTC_1766 st045414 44.774 µM 0.840466725387802 0.203632177812316 no 717 0.200323375336582 1048 253960
SGTC_347 4534-1311 26.2 µM 0.839522959444734 0.203887024430135 no 718 0.200587955420965 995 2862016
SGTC_697 0508-1955 564 µM 0.838910055391059 0.204052629642144 no 719 0.200759892345786 1021 6243113
SGTC_1274 0865-0114 173 µM 0.838654150289062 0.2041217982969 no 720 0.200831707135405 981 870624
SGTC_595 3909-8003 73.7 µM 0.838653997479433 0.204121839604025 no 721 0.200831750023061 996 699517
SGTC_2731 amoxapine 43.43 µM 0.837908496551853 0.204323420850972 no 722 0.201041048240743 973 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1840 st055363 71 µM 0.834659184486457 0.205203408326224 no 723 0.201954814298446 917 676033
SGTC_1180 1193-0155 285 µM 0.834463153685747 0.205256569845434 no 724 0.202010021151063 956 2921347
SGTC_707 0865-0008 204 µM 0.832431273979123 0.205808076311128 no 725 0.20258277777854 1043 723043
SGTC_2105 5350118 200 µM 0.832038513259798 0.20591478338501 no 726 0.202693603021787 1000 2133313
SGTC_1247 0448-0043 5.84 µM 0.83046967503822 0.206341339953402 no 727 0.203136643167691 1007 3089013 YGL099W LSG1
SGTC_3112 9123419 49.47 µM 0.828972100286084 0.206749008566261 no 728 0.203560097345173 1059 17015854
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.828568794518893 0.206858877592283 no 729 0.203674225985852 1023 4213774
SGTC_1501 4491-0275 38.4 µM 0.822584319827194 0.208493232387203 no 730 0.205372209247406 1028 5104718
SGTC_306 1672-3436 11.6 µM 0.821795707548635 0.208709168073099 no 731 0.205596588573678 1043 6797378
SGTC_54 0159-0055 9 µM 0.820949150820465 0.20894111658211 no 732 0.205837616387688 1015 3319099
SGTC_96 0929-0093 37.281 µM 0.820905446307428 0.208953095324399 no 733 0.205850064288783 962 6991579
SGTC_1484 3473-2379 286 µM 0.820172253522357 0.209154112625706 no 734 0.206058958536674 1185 671917
SGTC_2596 sinensetin 100 µM 0.819579632334537 0.209316673001879 no 735 0.206227894304324 951 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2375 9072683 200 µM 0.819202570031805 0.209420142677837 no 736 0.206335424425955 1096 16798029
SGTC_1094 duloxetine 25.4 µM 0.818748280268298 0.209544844306863 no 737 0.206465022293612 996 60834 A selective serotonin reuptake inhibitor.
SGTC_2069 5228469 200 µM 0.818713732330172 0.209554329433421 no 738 0.206474879956461 966 2835210
SGTC_680 0417-1641 114 µM 0.817887140632787 0.209781345245938 no 739 0.20671081688396 959 2835990
SGTC_1786 berberine 21.6 µM 0.815247650749268 0.210507224196789 no 740 0.20746528360184 963 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1608 st001473 40.5 µM 0.813125573389056 0.211091878472098 no 741 0.208073032778639 967 7292267
SGTC_2488 5268135 45.7 µM 0.812405946964069 0.211290358886594 no 742 0.208279367475463 1040 1270356 YLR208W SEC13
SGTC_361 000s-0510 1.45 µM 0.811742025247101 0.211473572291322 no 743 0.208469837270828 999 660
SGTC_21 0849-0113 22.993 µM 0.810612524789172 0.21178547876769 no 744 0.208794110968208 1027 1560156
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.810516864641368 0.211811907246524 no 745 0.208821588143973 952 2374 Ca(2+)-ATPase inhibitor.
SGTC_1829 berberine 14.4 µM 0.808702582295827 0.212313512810806 no 746 0.209343121239171 1018 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3234 9132280 49.47 µM 0.805963497719232 0.213072117763679 no 747 0.210131948282329 1038 17612295
SGTC_2700 st077718 96.8 µM 0.804519772180029 0.213472601258085 no 748 0.210548427524865 975 904970
SGTC_311 1315-0136 58 µM 0.803602175644078 0.213727366607418 no 749 0.210813383113053 1031 6759207
SGTC_3113 9123498 49.47 µM 0.802297703289984 0.214089850449011 no 750 0.211190385323465 1112 8897275
SGTC_1617 st002906 78 µM 0.799145460843279 0.214967263921644 no 751 0.21210303596516 1037 5150859
SGTC_2287 7945887 168.79 µM 0.79867848606929 0.215097421759553 no 752 0.212238432332619 1070 1245853
SGTC_2681 menadione 3.18 µM 0.797892626568249 0.215316564199232 no 753 0.212466401312682 1049 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1640 st009078 66.4 µM 0.797346728440223 0.215468867949237 no 754 0.212624844369682 983 690618
SGTC_1826 st055655 41.6 µM 0.796348285159156 0.21574759189132 no 755 0.212914813892634 1022 676168
SGTC_1951 sophoraflavanone G 9.2 µM 0.794300259358157 0.216319969299616 no 756 0.213510326546538 1050 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1859 st055998 20 µM 0.793691689276313 0.216490220285592 no 757 0.21368746979786 1066 676301
SGTC_2060 5238662 140 µM 0.793239322511584 0.216616822714708 no 758 0.213819200669003 987 790130
SGTC_2980 9014342 25.29 µM 0.791701644047026 0.217047487910964 no 759 0.214267331742398 970 2996599
SGTC_1011 4112-3381 17.4 µM 0.790548406407953 0.217370805305966 no 760 0.214603782111718 1039 2877139
SGTC_2923 7992654 58.14 µM 0.786924631026496 0.218388561417776 no 761 0.215662993880845 1032 2985126
SGTC_1701 st028638 40.4 µM 0.785056031735771 0.218914437978926 no 762 0.216210358629887 1073 3490878
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.783342307153741 0.219397368182882 no 763 0.216713062691359 1046 6708760
SGTC_1278 0874-0585 172 µM 0.783050846476921 0.21947956311164 no 764 0.216798626989961 1069 766306
SGTC_1645 Cervolide 78 µM 0.782819847955897 0.219544719650621 no 765 0.21686645524811 1010 23173 A fragrance.
SGTC_788 1182-0090 188 µM 0.782018538144786 0.219770826995453 no 766 0.21710183948095 1133 5715185
SGTC_3078 9116413 49.47 µM 0.781753726256455 0.219845578924622 no 767 0.217179660240073 1054 17177322
SGTC_99 0109-0120 622.8 µM 0.780098631996855 0.220313114631476 no 768 0.21766641080958 1060 759414
SGTC_342 k048-0088 23.3 µM 0.779211426939858 0.220563969321833 no 769 0.217927589969268 1073 6820570
SGTC_1460 k062-0059 9.15 µM 0.777888279695275 0.220938389279015 no 770 0.218317439152596 1075 1373085
SGTC_211 3455-0679 143.504 µM 0.777256426215989 0.221117317427596 no 771 0.218503748715856 1106 748649
SGTC_2426 5582046 32.21 µM 0.776655412850636 0.221287589193425 no 772 0.218681049632519 1061 2251934
SGTC_1331 1472-0049 76.2 µM 0.776197026890976 0.221417503898457 no 773 0.218816330641332 1057 24051409
SGTC_2120 5538279 151.968 µM 0.775864456765392 0.221511787457174 no 774 0.218914510427504 1068 2058197
SGTC_2593 nobiletin 86.24 µM 0.77520642280525 0.221698407554627 no 775 0.21910884677184 1028 72344 An anti-infammatory.
SGTC_37 0566-0070 1.56 µM 0.775141100028449 0.221716938159751 no 776 0.21912814387645 1102 1626686
SGTC_3306 9127676 59.7925 µM 0.774679289163856 0.221847968773515 no 777 0.219264596023441 1069 41905287
SGTC_2694 st077685 81.9 µM 0.773087749645233 0.222299878499217 no 778 0.219735225283827 1081 2838096
SGTC_1113 artemisinin 1.17947 µM 0.766715897669484 0.224114385619741 no 779 0.22162522471891 1116 2240 An anti-malaria and mitochondrial poison.
SGTC_966 1300-0360 30.2 µM 0.766707727907468 0.224116717503179 no 780 0.221627653957193 1057 70588
SGTC_961 1252-1571 372 µM 0.765244184496639 0.224534676894947 no 781 0.222063076801662 1058 6813498
SGTC_2072 5231554 129 µM 0.765067697579525 0.224585107972531 no 782 0.222115616887017 1171 789545
SGTC_313 3474-0040 5.03 µM 0.764308128042811 0.22480222804038 no 783 0.22234182140312 1093 1043375 YIL048W NEO1
SGTC_2147 5545932 89.7195 µM 0.763670434323016 0.224984602235687 no 784 0.222531831982948 1073 797404
SGTC_2448 5185112 27.17 µM 0.762350020953706 0.225362494045524 no 785 0.222925563503784 1054 5718189
SGTC_3280 9140961 49.47 µM 0.760605056325733 0.225862439902385 no 786 0.223446499380309 1068 4901226
SGTC_2271 7849410 118.62 µM 0.760526323128462 0.225885012350468 no 787 0.223470020442177 1101 972430
SGTC_2786 7743617 45.45 µM 0.759944852467414 0.2260517568273 no 788 0.223643774858732 1018 583674
SGTC_2558 carylophyllene oxide 100 µM 0.757786365448078 0.226671339927809 no 789 0.224289443013486 1186 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.757027779448953 0.226889315703553 no 790 0.224516609891484 1074 4620898
SGTC_1600 coumarin 106 71.1 µM 0.755157635521298 0.227427196641692 no 791 0.225077202238246 1103 100336 A hepatotoxic, DNA x-linker.
SGTC_1713 st033146 12.748 µM 0.754365275228781 0.227655307586774 no 792 0.225314958308085 1099 674619
SGTC_3158 9100007 49.47 µM 0.750076719646721 0.228892163607515 no 793 0.226604249884144 1103 19297233
SGTC_2883 9059145 45.46 µM 0.749984366047466 0.228918840590193 no 794 0.22663206037279 1123 16476510
SGTC_909 3448-9333 149 µM 0.748971859755216 0.229211424506624 no 795 0.226937083237709 1052 3344074
SGTC_3130 9127414 49.47 µM 0.747326535922011 0.229687320638771 no 796 0.227433239195801 1156 1494646
SGTC_2289 7946404 165.07 µM 0.746599537355054 0.229897775039818 no 797 0.227652663885509 1179 1246120 YPR165W RHO1
SGTC_2587 piperic acid 92.2 µM 0.745897179153608 0.230101198929557 no 798 0.227864764696237 1081 5370536
SGTC_1243 0416-0003 5.65 µM 0.744096220006578 0.230623270345754 no 799 0.228409132989189 1112 2141977
SGTC_2720 fluspirilene 36.88 µM 0.741913199958414 0.231256981972747 no 800 0.229069963846884 1081 3396 An atypical antipsychotic.
SGTC_2979 9012552 45.46 µM 0.740722124042958 0.231603150069699 no 801 0.229430971013563 1123 17100905
SGTC_3355 9151058 44.0485 µM 0.740155562414533 0.231767913897972 no 802 0.229602803911862 1153 17015728
SGTC_2030 5175110 200 µM 0.739978058776503 0.231819547801855 no 803 0.229656653950913 1155 2831986
SGTC_924 2046-0044 21.3 µM 0.73917274253708 0.232053886121136 no 804 0.229901055022586 1157 3623589
SGTC_1276 0871-0068 94.2 µM 0.738930176780762 0.23212449596852 no 805 0.229974698514163 1101 3414906
SGTC_3192 9110362 49.47 µM 0.738348147487234 0.232293970954735 no 806 0.23015145771047 1160 16649480
SGTC_1364 1653-0028 37.6 µM 0.736573011642626 0.232811279009319 no 807 0.23069102612349 1093 5718652
SGTC_2606 farnesol 9.78 µM 0.735900303122398 0.233007486077967 no 808 0.230895686392687 1131 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_34 0469-0683 81.75 µM 0.735016428569326 0.233265422908026 no 809 0.23116474442563 1132 3690923
SGTC_2388 9080168 200 µM 0.733828475372722 0.233612347016753 no 810 0.231526641690585 1109 15943073
SGTC_578 3460-0051 92 µM 0.732547423570968 0.233986779577876 no 811 0.231917254139874 1209 2876744
SGTC_1816 st051957 91.6 µM 0.731426565290806 0.234314662435646 no 812 0.232259321937085 1134 674121
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.729795255625952 0.234792320866531 no 813 0.232757672469824 1176 688669
SGTC_1680 diphenhydramine 100 µM 0.729410908103514 0.234904938702264 no 814 0.232875173639127 1102 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_368 fentichlor 4.58 µM 0.729368748785952 0.234917293638895 no 815 0.232888064420364 1109 7329 A pesticide.
SGTC_3302 9125395 16.351 µM 0.728358413919511 0.235213483227173 no 816 0.233197106513872 1107 17599668
SGTC_1449 4112-4002 201 µM 0.728100827216191 0.235289030274412 no 817 0.233275933756103 1131 2059539
SGTC_1002 4049-0206 172 µM 0.727807539149057 0.235375064404654 no 818 0.233365704408306 1184 4662749
SGTC_432 NS 1619 61.3 µM 0.725471176701598 0.23606104073331 no 819 0.234081510615811 1090 4552 A K+/calcium channel activator.
SGTC_2450 5739737 12.93 µM 0.725448747314679 0.236067631530032 no 820 0.2340883883372 1131 2262825
SGTC_1077 5-fluorocytosine 377 nM 0.724128150156326 0.236455863039361 no 821 0.234493531944655 1119 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1808 st050063 61.5 µM 0.723247449363181 0.236714968230847 no 822 0.234763936010925 1138 4011993
SGTC_2411 st077133 39.94 µM 0.721351912065605 0.23727317119497 no 823 0.235346512560556 1196 1403142 YNL221C POP1
SGTC_417 st075190 100 µM 0.72072850247419 0.237456912399213 no 824 0.23553828620122 1160 222757
SGTC_314 1671-0008 2.74 µM 0.720631411236149 0.237485535703449 no 825 0.235568161224852 1104 3913060
SGTC_2945 9067681 61.76 µM 0.719264357324618 0.237888755563292 no 826 0.235989026270247 1225 16456930
SGTC_1139 k015-0024 46.9 µM 0.719082505284786 0.237942422070423 no 827 0.23604504295803 1157 2766652
SGTC_363 0455-0021 3.06 µM 0.718236782335382 0.238192091268944 no 828 0.236305650976521 1170 4597466
SGTC_2924 9010168 62.78 µM 0.713906295389985 0.239472757709415 no 829 0.237642562146228 1189 2993929
SGTC_469 w7 172 µM 0.71212349429789 0.240001080751697 no 830 0.238194153425105 1209 45115570 A P450 inhibitor.
SGTC_663 1486-0733 13.9 µM 0.711133686038284 0.240294679005124 no 831 0.238500698579958 1158 722445 YPR165W RHO1
SGTC_1205 4161-2785 76 µM 0.710941148070749 0.240351812602033 no 832 0.238560352969255 1116 3498106
SGTC_563 tetrahydrosecaminediol 614 µM 0.710356452510525 0.240525360150136 no 833 0.238741560309699 1216 334274 A psychoactive constituent of the cannabis plant.
SGTC_1492 4158-0558 28.5 µM 0.709999659081137 0.240631295998466 no 834 0.238852173795399 1166 3967268
SGTC_1922 5578187 25 µM 0.709546387034812 0.240765914018273 no 835 0.238992738101595 1167 1350412
SGTC_1289 0976-0073 69.1 µM 0.708867555369615 0.240967597986996 no 836 0.239203335316347 1199 3391136
SGTC_2282 7944268 200 µM 0.708068550315886 0.241205103691537 no 837 0.239451344365349 1196 2970414
SGTC_842 0271-0008 11.1 µM 0.707594193666089 0.241346167237501 no 838 0.239598649812244 1197 1221709
SGTC_423 5-fluorouracil 457 µM 0.707591009363564 0.241347114332558 no 839 0.239599638824158 1156 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1109 tnp00067 928.257 nM 0.706869265313282 0.241561832025567 no 840 0.23982386265492 1165 676295
SGTC_1516 st013856 110 µM 0.706222947071998 0.241754198663039 no 841 0.240024751103947 1137 5281404 A mutagen and neurotoxin.
SGTC_1204 4049-0315 18.3 µM 0.704673339544849 0.242215753839789 no 842 0.240506773146598 1172 588402
SGTC_1784 st039334 36.3 µM 0.704038542331043 0.242404967888689 no 843 0.240704385719655 1210 3496984
SGTC_79 0052-0007 94.094 µM 0.703679346489166 0.242512068884199 no 844 0.240816242635513 1216 2801472
SGTC_324 1315-0088 19.6 µM 0.702740829838707 0.242792026201844 no 845 0.241108638864675 1125 6787421
SGTC_1553 gossypol 38.6 µM 0.69993181733634 0.243630992257453 no 846 0.24198494303605 1115 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1527 coumarin 137 µM 0.699475608919343 0.243767395364273 no 847 0.242127425449713 1177 323 A hepatotoxic, DNA x-linker.
SGTC_2134 5324836 1.464 µM 0.699276952501102 0.243826805116816 no 848 0.242189483774547 1142 699272
SGTC_2649 anisomycin 9.56 µM 0.698069531903532 0.244188061698189 no 849 0.242566855575798 1163 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2803 7707263 71.43 µM 0.697754814838288 0.244282271481992 no 850 0.242665270729519 1174 2199229
SGTC_1245 0418-0076 17.2 µM 0.694911946124096 0.245134164418189 no 851 0.243555242849982 1185 6790114
SGTC_1982 st072467 71.9 µM 0.693796431676869 0.2454688749848 no 852 0.243904940364039 1168 3163533
SGTC_1735 st034310 56.75 µM 0.693505939258326 0.245556077635859 no 853 0.243996049944177 1194 871153
SGTC_1677 st019204 53.9 µM 0.693446498680101 0.245573923098883 no 854 0.244014695055081 1150 3945625
SGTC_1098 clofazimine 15.1 µM 0.693445216081382 0.245574308172936 no 855 0.244015097384594 1222 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_372 0155-0182 15.9 µM 0.693393431765896 0.245589855626263 no 856 0.24403134154689 1196 771486
SGTC_169 k015-0017 16.025 µM 0.693341550822282 0.245605432620886 no 857 0.244047616605274 1231 1840002
SGTC_479 n-linoleoylglycine 10 µM 0.692996585249232 0.245709020307576 no 858 0.244155847234878 1201 6433346 An anti-infammatory.
SGTC_1166 k206-0078 225 µM 0.692218322168136 0.245942806497552 no 859 0.244400117078017 1211 5404595
SGTC_1430 4049-0248 69.1 µM 0.69186625513492 0.246048604806086 no 860 0.244510661980111 1242 22774488
SGTC_1387 3342-1166 1.8 µM 0.691843096838132 0.246055564872385 no 861 0.24451793435661 1172 3418228
SGTC_435 c-PAF 6.7 µM 0.690266688788097 0.246529591625894 no 862 0.245013245992615 1180 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1366 1683-0113 21.9 µM 0.689538687346896 0.24674866708218 no 863 0.245242168058867 1223 708623
SGTC_1999 st074831 12.5 µM 0.689332439150002 0.246810751723727 no 864 0.245307044272643 1193 17112523
SGTC_3028 9087778 49.47 µM 0.688489119707203 0.247064693941328 no 865 0.245572409804796 1176 17217395
SGTC_861 0443-0273 110 µM 0.687490956390058 0.247365443623229 no 866 0.245886698886913 1207 6149169
SGTC_1213 1315-0166 115 µM 0.686753056527785 0.247587900864975 no 867 0.246119178202617 1168 768401
SGTC_1482 3346-2049 8.48 µM 0.685995383150064 0.247816430453119 no 868 0.246358009888816 1199 3826804
SGTC_2655 perillic acid 100 µM 0.68562434981968 0.24792838265817 no 869 0.246475011274146 1197 5702197 An apoptosis inducer.
SGTC_3285 9112818 20.8695 µM 0.68491930263544 0.248141191503797 no 870 0.246697422368645 1258 17017947 YPR165W RHO1
SGTC_131 0141-0277 33.849 µM 0.68436003030411 0.248310069474331 no 871 0.246873924376781 1163 1547771
SGTC_430 0958-0115 16.4 µM 0.684054894733925 0.24840223409297 no 872 0.246970251285826 1179 6833180
SGTC_60 0986-0278 202 µM 0.682621729818129 0.248835357948792 no 873 0.247422949768253 1056 3110598
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.682573878656536 0.248849826217558 no 874 0.247438072317823 1218 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1359 1582-0056 520 nM 0.682425527248072 0.248894684569393 no 875 0.247484959408475 1247 3661189
SGTC_1623 st003709 20.3 µM 0.682306469931423 0.248930688115664 no 876 0.247522591410953 1215 16192618
SGTC_2563 tomatine 8.54 µM 0.681496545169254 0.249175687085612 no 877 0.247778676041088 1218 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2019 4016004 108 µM 0.681154062892412 0.249279325158366 no 878 0.247887005733992 1190 45595336
SGTC_3147 9097027 49.47 µM 0.680041996246704 0.249616004030308 no 879 0.248238934929562 1239 25236841
SGTC_2718 lomofungin 53.02 µM 0.679291130083572 0.249843465763186 no 880 0.248476707721019 1243 5351222 A RNA synthesis inhibitor.
SGTC_3281 9140613 49.47 µM 0.677526239521013 0.25037854137253 no 881 0.249036063758044 1165 16013766
SGTC_2674 ligustilide 100 µM 0.677010511400318 0.25053501328743 no 882 0.249199642579623 1196 5319022 A signalling regulator.
SGTC_2114 5491910 81.25 µM 0.676730938545108 0.250619857344193 no 883 0.249288341471575 1264 2849228
SGTC_1384 3089-0840 101 µM 0.67511681367002 0.251110005300077 no 884 0.249800776065095 1206 1069836
SGTC_1684 st024538 14.6195 µM 0.674663058438779 0.25124788465517 no 885 0.249944929919654 1215 6732859
SGTC_2824 7998404 51.95 µM 0.673458430412054 0.251614120477559 no 886 0.250327843221253 1204 837851
SGTC_2911 7942208 15.64 µM 0.673053611635141 0.251737258375235 no 887 0.250456592138618 1211 1243384
SGTC_2368 9071271 200 µM 0.672773607023845 0.251822448876201 no 888 0.250545665576492 1217 27209959
SGTC_1647 st011722 22.4 µM 0.672543262244422 0.251892541941933 no 889 0.25061895409856 1232 2854783
SGTC_2505 galangin 7.89 µM 0.672436845406788 0.251924927670001 no 890 0.250652816450774 1162 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2106 5357045 167.29 µM 0.672343303598936 0.251953396968077 no 891 0.25068258390747 1242 668842
SGTC_2598 perillyl alcohol 100 µM 0.669248726200721 0.25289618297052 no 892 0.251668414210104 1243 10819 An apoptosis inducer.
SGTC_2232 chlorophetanol 41.5365 µM 0.667925478303359 0.253299886282735 no 893 0.252090581472351 1300 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2507 purpurin 79.67 µM 0.666931459862315 0.253603369267348 no 894 0.252407957355325 1230 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1486 3970-0793 4.53 µM 0.666801944036628 0.253642925701225 no 895 0.252449325409599 1264 2844330
SGTC_1846 st056244 14.8 µM 0.665047534033377 0.254179072776216 no 896 0.253010045265546 1253 5393182
SGTC_787 4152-0075 138 µM 0.66418767758191 0.254442061462783 no 897 0.253285099591489 1263 9566539
SGTC_2228 7354201 200 µM 0.663866343985408 0.254540378525434 no 898 0.253387929407892 1265 753451
SGTC_2849 9019321 12.99 µM 0.662683605742084 0.254902427245024 no 899 0.253766605863877 1225 16489627
SGTC_509 pifithrin 175 µM 0.662015620923251 0.255107023505252 no 900 0.253980605303878 1281 4817 A p53 inhibitor.
SGTC_2534 helenine 20.12 µM 0.661567683973185 0.255244269665681 no 901 0.25412416197135 1261 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_174 3553-0389 74.3 µM 0.659053770964326 0.256015238653454 no 902 0.254930620097492 1241 738071
SGTC_828 2074-0507 139 µM 0.658933293044598 0.256052217406326 no 903 0.254969302768655 1294 X828
SGTC_329 k048-0121 21.3 µM 0.657992072661296 0.256341205687918 no 904 0.25527161253464 1249 6832902
SGTC_1896 st058441 89 µM 0.656450466949402 0.256814900680562 no 905 0.255767164059556 1209 688759
SGTC_1154 4088-0362 150 µM 0.656270121961185 0.256870345715882 no 906 0.255825169027769 1269 6618304
SGTC_475 α-linolenic acid 10 µM 0.655951760026447 0.256968237709023 no 907 0.25592758160976 1344 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_510 ag-490 170 µM 0.654923268196705 0.257284617628385 no 908 0.256258579181562 1365 5328779
SGTC_1087 pterostilbene 9.05 µM 0.653994160066869 0.257570599558625 no 909 0.256557784035139 1308 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3341 9147222 25.867 µM 0.650918858711856 0.258518361633964 no 910 0.257549433486543 1247 1939759
SGTC_110 0850-0284 111.64 µM 0.647035577852006 0.259717706142317 no 911 0.258804458830722 1143 3906265
SGTC_2374 9071832 200 µM 0.646946786235503 0.259745162820966 no 912 0.258833192078417 1244 17381698
SGTC_219 mitoxanthrone 164.414 µM 0.645573887109684 0.260169889523678 no 913 0.259277676560256 1268 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2611 pyromycin 23.93 µM 0.645345782490708 0.260240491732396 no 914 0.259351565019254 1252 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1458 k015-0034 6.33 µM 0.645219148901061 0.260279691215748 no 915 0.259392589317517 1235 3598957
SGTC_1887 st057648 70.8 µM 0.645110684607624 0.260313268804222 no 916 0.259427730144192 1271 688672
SGTC_1821 st053465 65.6 µM 0.644860175144213 0.260390828233788 no 917 0.259508900902325 1235 675086
SGTC_1805 st050013 60.3 µM 0.643906258184051 0.260686276319879 no 918 0.259818111689498 1236 4037144
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.643898991156891 0.260688527732549 no 919 0.259820468015108 1267 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2075 5212009 200 µM 0.642954695371337 0.260981167066896 no 920 0.260126748666469 1237 780898
SGTC_190 3970-0790 3.722 µM 0.642733682769259 0.261049683742969 no 921 0.260198460577915 1272 2832352
SGTC_985 1493-0307 8.71 µM 0.641612235428091 0.26139748892488 no 922 0.260562493307572 1256 3278274
SGTC_160 3453-0671 289.699 µM 0.641424992838922 0.261455583434658 no 923 0.260623299610137 1232 5322268
SGTC_1992 st073643 23.3 µM 0.639989289004363 0.261901249890964 no 924 0.261089781445287 1263 3161292
SGTC_883 0850-0245 24.6 µM 0.638821348547963 0.262264085259741 no 925 0.26146957925649 1348 6823229 YPR165W RHO1
SGTC_643 k048-0106 28.4 µM 0.638096019515888 0.262489547372828 no 926 0.261705588765694 1311 6763920
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.637907973503474 0.262548016004424 no 927 0.261766793520041 1325 5393153
SGTC_1993 st073995 70.8 µM 0.632915046935747 0.264102887379856 no 928 0.263394560587132 1288 3098394
SGTC_2735 sertaconazole 140 nM 0.632515907261589 0.264227387590559 no 929 0.26352490867115 1363 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.632405265369484 0.264261904456 no 930 0.263561047108973 1318 5377381
SGTC_1207 2099-0101 141 µM 0.63087436872783 0.264739732655058 no 931 0.264061336074176 1306 5837381
SGTC_25 0118-0223 35.662 µM 0.629587771536455 0.265141648837688 no 932 0.264482163148859 1331 5333628
SGTC_2657 nystatin 74.44 µM 0.628157067803089 0.265588945634975 no 933 0.264950525793968 1307 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_23 0213-0011 39.996 µM 0.628128190023254 0.265597977954889 no 934 0.264959983712412 1329 627608
SGTC_2988 9073640 71.4286 µM 0.62571675606872 0.266352769516508 no 935 0.265750370379359 1333 9102229
SGTC_760 0568-0725 82.9 µM 0.625486567192486 0.266424876560138 no 936 0.265825880969929 1310 3916171
SGTC_1929 genistein trimethyl ether 50.5 µM 0.625333175368222 0.266472932283657 no 937 0.265876205282081 1317 136420
SGTC_71 0417-1750 47.813 µM 0.625132321306683 0.266535863956141 no 938 0.265942108156163 1309 6811472
SGTC_283 0987-0079 11.7 µM 0.624436264712512 0.266754010821377 no 939 0.266170557550902 1312 411556
SGTC_84 0443-0269 128.823 µM 0.622401155901006 0.267392339081047 no 940 0.2668390602831 1264 6150058
SGTC_2515 chrysin 20.77 µM 0.621686798863072 0.26761658547381 no 941 0.26707391685356 1323 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1518 st038567 90.8 µM 0.621434659194984 0.267695758175023 no 942 0.267156836810449 1296 77966
SGTC_1118 chelidonine 707.474 nM 0.619829454450022 0.268200074475399 no 943 0.267685037296567 1331 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1731 st035964 63 µM 0.619689449708124 0.268244083217395 no 944 0.267731131484636 1348 6739575
SGTC_1939 st074455 53.6 µM 0.618899002982124 0.268492618415331 no 945 0.267991447683855 1395 1644229
SGTC_2875 9039966 71.43 µM 0.617043969685483 0.269076339156104 no 946 0.268602862060669 1412 6463691
SGTC_2697 mebhydrolin 72.4 µM 0.614629635365593 0.269837006992788 no 947 0.269399669240062 1360 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2492 derrusnin 100 µM 0.61452173614773 0.269871027179062 no 948 0.269435307060765 1247 1715307 Part of coumarin class of compounds.
SGTC_1831 st055328 12 µM 0.614173413364044 0.269980866593883 no 949 0.269550370035118 1334 1103068
SGTC_1825 st052143 62.6 µM 0.613388275618687 0.270228532391906 no 950 0.269809818259609 1357 674173
SGTC_1558 st069300 45.6 µM 0.611576366031352 0.270800518930498 no 951 0.270409039376507 1300 24208000
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.611355011473203 0.270870437897893 no 952 0.270482289656676 1305 15053
SGTC_456 gingerol 170 µM 0.610253579825647 0.271218479528703 no 953 0.270846920918608 1368 442793 A herb.
SGTC_1928 4'-methoxychalcone 40.3 µM 0.610057091057064 0.27128059148344 no 954 0.27091199471607 1393 641818
SGTC_1627 st003713 25.6 µM 0.609139471622253 0.271570753485922 no 955 0.271215998198919 1347 16195070 YER133W GLC7
SGTC_2799 7812892 81.82 µM 0.607277889043834 0.272159882093349 no 956 0.271833254742869 1344 20205235
SGTC_2646 retinol 96.75 µM 0.606954893532717 0.272262164002759 no 957 0.271940423496992 1335 445354 A vitamin A analog and teratogen.
SGTC_952 1185-0122 232 µM 0.604890232524244 0.272916424245264 no 958 0.27262596676065 1269 678600
SGTC_2452 5863136 48.41 µM 0.603824266264527 0.273254517945239 no 959 0.27298024215018 1304 2184096
SGTC_2706 st078239 82.5 µM 0.602458045957547 0.273688146706402 no 960 0.273434640890966 1325 15434492
SGTC_1790 st045711 43.5 µM 0.59861767665551 0.274908873373442 no 961 0.274713932823098 1393 585119
SGTC_1489 4065-0444 182 µM 0.598525394298971 0.274938239869106 no 962 0.274744709910415 1327 2877968
SGTC_1418 3966-3099 2.4 µM 0.598519165007368 0.274940222237253 no 963 0.274746787502613 1364 740335
SGTC_264 promethazine 12.5 mM 0.598241175633477 0.275028694888083 no 964 0.274839510352974 1359 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.597614654239817 0.275228142436303 no 965 0.275048541962485 1368 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2274 7947094 46.08 µM 0.593748461296909 0.276460483874569 no 966 0.276340182432977 1329 2971028
SGTC_962 1254-0300 21.5 µM 0.59189453423152 0.277052377811106 no 967 0.276960607053916 1364 7340576
SGTC_717 1532-0246 73.2 µM 0.591233238384007 0.277263656373202 no 968 0.277182077433607 1332 9561992
SGTC_934 2950-0684 338 µM 0.590740568238148 0.277421111624288 no 969 0.277347130753909 1405 1121253
SGTC_2059 5238311 157 µM 0.590392161666896 0.277532487240401 no 970 0.27746388219663 1343 703021
SGTC_3258 9138477 49.47 µM 0.5897088189254 0.277750995807503 no 971 0.277692940876563 1397 4970355
SGTC_228 caffeine 993.056 µM 0.585213101501447 0.279190656332845 no 972 0.279202218264829 1374 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2566 crystal violet carbinol 226 nM 0.584762075950306 0.279335287894287 no 973 0.279353853855718 1299 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3058 9093861 49.47 µM 0.582555772104819 0.280043313312761 no 974 0.280096193135869 1379 17217477
SGTC_1899 st063254 59.6 µM 0.581959992232717 0.28023465421529 no 975 0.280296814745173 1301 3093813
SGTC_2864 9034755 47.6 µM 0.58174524869337 0.280303636860811 no 976 0.280369144074284 1356 4930451
SGTC_665 3914-0008 307 µM 0.581566895672856 0.280360935932997 no 977 0.280429223318053 1310 1069549
SGTC_1687 st020778 55.3625 µM 0.580810178574549 0.280604107788833 no 978 0.280684197135315 1371 4259299
SGTC_1021 4476-0760 85.3 µM 0.57972509233065 0.280952979408175 no 979 0.28105000964011 1332 746768
SGTC_1690 st023502 41.2 µM 0.579560708221182 0.281005849661287 no 980 0.281105448142444 1402 24207482
SGTC_218 alverine citrate 93.75 µM 0.574726910667575 0.282562671422001 no 981 0.282738002258562 1398 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2956 9076196 2.52 µM 0.574628887382355 0.282594284640119 no 982 0.282771155456393 1402 16423868
SGTC_2936 9038235 15.59 µM 0.573906249019767 0.282827393188149 no 983 0.283015622067385 1365 4749415
SGTC_1833 st055984 71 µM 0.570754444163533 0.283845180271902 no 984 0.284083053715964 1374 676288
SGTC_2584 androsterone 48.74 µM 0.570542025649531 0.283913837896488 no 985 0.284155063371366 1404 2754130 A steroid.
SGTC_1621 st003705 32.4 µM 0.56677778476148 0.285131827207735 no 986 0.28543258278682 1436 24207032
SGTC_2352 9027995 87.8 µM 0.562356717656898 0.286565517169558 no 987 0.286936501105592 1407 2997347
SGTC_3000 9075062 71.4286 µM 0.562335243830992 0.286572489166779 no 988 0.286943815028355 1377 17057871
SGTC_1382 3002-2117 298 µM 0.561654705210916 0.28679348416742 no 989 0.28717565024608 1471 1497314
SGTC_590 k048-0076 22.4 µM 0.559831384465342 0.287385978816069 no 990 0.287797227181808 1462 6832814
SGTC_895 0964-0006 13.7 µM 0.556688114627035 0.288408753010036 no 991 0.288870269409119 1370 6738897
SGTC_209 4077-0173 175.592 µM 0.555847890098533 0.288682440175409 no 992 0.289157421943488 1363 15993494
SGTC_940 3232-1287 54.8 µM 0.553680809372882 0.289388889502592 no 993 0.28989865555631 1379 1585493 YIL048W NEO1
SGTC_2180 6301957 200 µM 0.553026482589902 0.289602353831464 no 994 0.290122638122762 1388 845462
SGTC_2226 7298446 200 µM 0.550847318545743 0.29031380603579 no 995 0.290869171833509 1421 3283010
SGTC_2481 5478948 45.16 µM 0.550669699035323 0.290371831208789 no 996 0.290930059928976 1402 77792
SGTC_1271 0832-2808 169 µM 0.550212033822727 0.29052136740861 no 997 0.291086975332167 1444 3663794
SGTC_416 estradiol valerate 100 µM 0.548412631651879 0.291109647949082 no 998 0.291704302484801 1418 13791 A steroid.
SGTC_2133 5320837 200 µM 0.548328641386428 0.291137120564166 no 999 0.291733132216167 1453 2841355
SGTC_815 1582-0027 36.9 µM 0.547967582626919 0.291255234089098 no 1000 0.29185708106864 1459 3128206
SGTC_1128 3448-9350 235 µM 0.547778956488968 0.291316948446387 no 1001 0.291921844807158 1404 619386
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.54404704194078 0.292539202336279 no 1002 0.2932045508518 1542 6728940
SGTC_2575 plumbagin 510 nM 0.543166457462134 0.292827953118897 no 1003 0.293507599443759 1361 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_724 3910-0327 137 µM 0.540767982098095 0.293615102838224 no 1004 0.294333757092487 1394 2885483
SGTC_1202 1988-0068 29.6 µM 0.540514172153454 0.293698457382283 no 1005 0.294421245020235 1361 2850480
SGTC_1188 1403-0014 4.57 µM 0.540458416465997 0.293716769754864 no 1006 0.294440465534728 1424 9614867
SGTC_777 1315-0167 517 µM 0.539671601092862 0.293975247362304 no 1007 0.294711764109631 1374 4221767
SGTC_270 tamoxifen 5.46 µM 0.539022554883287 0.294188545395991 no 1008 0.294935645797787 1529 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1408 3909-7976 48.8 µM 0.53814698250687 0.294476400651318 no 1009 0.295237789423018 1447 24152374
SGTC_282 k297-0036 65.7 µM 0.537245416409806 0.294772937437844 no 1010 0.295549051796206 1447 5061378
SGTC_1873 rapamycin 2 nM 0.536100162185956 0.295149824814409 no 1011 0.295944664023464 1437 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1676 st018489 23.4 µM 0.534069646932193 0.295818584246803 no 1012 0.296646674463713 1457 3696235
SGTC_2117 5521686 200 µM 0.534013031018127 0.295837240926215 no 1013 0.296666259219619 1389 803312
SGTC_50 0929-0078 56.389 µM 0.532856548918731 0.296218455449312 no 1014 0.297066442679894 1492 1377751
SGTC_1902 st060212 70.5 µM 0.530437583336456 0.297016553704489 no 1015 0.29790428697082 1438 688944
SGTC_685 1278-0033 54.9 µM 0.530396938342203 0.297029972255728 no 1016 0.297918374161433 1505 3590572
SGTC_1970 st070122 35.8 µM 0.529611419885712 0.297289358008107 no 1017 0.298190687446619 1480 102928
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.527037230096091 0.298140104703741 no 1018 0.299083867412712 1436 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3276 9139060 49.47 µM 0.526790000812402 0.298221870110107 no 1019 0.299169713727991 1474 4870619
SGTC_1023 4482-3888 16 µM 0.526191285059712 0.298419923890012 no 1020 0.299377654274869 1531 3303168
SGTC_2553 4-methylesculetin 85.09 µM 0.52603316725444 0.298472238882269 no 1021 0.299432581261471 1419 5319502
SGTC_1075 aripiprazole 15.2 µM 0.525547073723125 0.298633094330334 no 1022 0.299601469112443 1433 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1656 st012921 11 µM 0.525021135153136 0.2988071794694 no 1023 0.299784249283935 1468 6732821
SGTC_2618 avocadyne 43.43 µM 0.523951921547246 0.299161230198724 no 1024 0.300155990175129 1446 3015189
SGTC_499 genistein 192 µM 0.521938531052397 0.299828444292245 no 1025 0.300856564794113 1513 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_546 peri-Naphthalide 147 µM 0.52104323176325 0.300125352266328 no 1026 0.301168327748181 1487 223824 A penicillin ester.
SGTC_2373 9071805 200 µM 0.521010214682697 0.300136304257885 no 1027 0.301179827806006 1554 10149009
SGTC_2357 9067248 200 µM 0.519476611626276 0.300645209921127 no 1028 0.301714209291149 1467 9150235
SGTC_68 0986-0284 82.829 µM 0.517273475751506 0.301376971963845 no 1029 0.302482633547691 1393 423278 YIL048W NEO1
SGTC_1910 st062352 60.4 µM 0.51655342215162 0.30161630838666 no 1030 0.302733968707796 1358 2245730
SGTC_1140 3229-1848 2.98 µM 0.516177647563365 0.301741244896702 no 1031 0.302865170199217 1487 2849525
SGTC_20 0481-0013 4.944 µM 0.515142116822832 0.302085655670497 no 1032 0.303226856854555 1439 182045
SGTC_2872 9044037 25.97 µM 0.514622568970551 0.302258520368593 no 1033 0.303408395483643 1515 6465195
SGTC_295 k015-0027 31 µM 0.5145309056333 0.302289023329981 no 1034 0.303440429211546 1448 3887424
SGTC_1206 3978-0017 132 µM 0.511272886602409 0.303374095367517 no 1035 0.304579993874404 1536 3873677
SGTC_3082 9117008 49.47 µM 0.510172158178271 0.303741082132244 no 1036 0.304965427933495 1464 41448529
SGTC_2610 ononetin 44.17 µM 0.50937780994795 0.304006043655031 no 1037 0.305243713588599 1439 259632
SGTC_180 1486-1293 102.781 µM 0.508895569794082 0.304166949156071 no 1038 0.305412712725808 1614 4140536
SGTC_820 1582-0060 59.9 µM 0.508689486455035 0.304235723028066 no 1039 0.305484946461679 1442 3848840
SGTC_2490 carminic acid 95.39 µM 0.507738031703411 0.304553331073104 no 1040 0.305818536549468 1461 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1474 0330-0125 5.35 µM 0.506710167353291 0.304896611295611 no 1041 0.306179097773326 1468 X1474
SGTC_103 0844-0104 51.839 µM 0.505972762264494 0.305142991463107 no 1042 0.306437885463694 1510 5375804
SGTC_706 4262-0057 46.9 µM 0.505869800466652 0.305177399863066 no 1043 0.306474026946712 1425 883298
SGTC_2984 9022109 38.96 µM 0.505000478829547 0.305467983678184 no 1044 0.306779249832621 1513 6459207
SGTC_451 chloral hydrate 100 µM 0.504174867720774 0.305744070108538 no 1045 0.307069249836293 1508 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2229 7354935 190 µM 0.503999169149735 0.305802838411387 no 1046 0.307130980418444 1490 318112
SGTC_1425 4048-4433 7.33 µM 0.502558546757113 0.30628489158741 no 1047 0.307637340031238 1520 23734946
SGTC_2957 9076800 11.52 µM 0.501343815275278 0.306691619172586 no 1048 0.308064587012083 1443 16459615
SGTC_575 k072-0246 11.9 µM 0.500869503265475 0.30685049736707 no 1049 0.308231483347132 1484 6796779
SGTC_299 1273-0059 1.44 µM 0.50067217104775 0.306916607557243 no 1050 0.308300930386784 1478 2848077
SGTC_1476 4112-3294 3.34 µM 0.499778169152424 0.307216194488398 no 1051 0.308615642006534 1558 704369
SGTC_2394 5221648 200 µM 0.498964904733617 0.307488837481146 no 1052 0.308902054133002 1633 788586
SGTC_118 0083-0097 135.343 µM 0.497514476600992 0.307975350563389 no 1053 0.309413148406751 1518 5207356
SGTC_2713 st079149 53.4 µM 0.496963886684593 0.30816012188395 no 1054 0.30960725905225 1513 3103253
SGTC_3327 9140648 26.9345 µM 0.49691159567848 0.308177672642637 no 1055 0.309625697025405 1547 8029710
SGTC_990 3985-0011 41.3 µM 0.49490561743137 0.308851282541901 no 1056 0.310333372622068 1488 5399565 YGL099W LSG1
SGTC_1146 3579-1023 7 µM 0.492988900497921 0.309495519682508 no 1057 0.311010215036005 1593 X1146
SGTC_398 bronopol 33.3 µM 0.492781025692243 0.309565424754657 no 1058 0.311083659510724 1517 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1299 1079-1439 3.74 µM 0.4888375445382 0.310892859113174 no 1059 0.312478357605867 1448 323161
SGTC_2295 7971645 200 µM 0.487896772174578 0.311209901847941 no 1060 0.312811480475348 1560 2978226 YKL099C UTP11
SGTC_1862 st057513 3.81 µM 0.486382713419304 0.311720437728514 no 1061 0.313347922272863 1481 5393163
SGTC_1622 st003707 19.4 µM 0.486091347619461 0.31181872693977 no 1062 0.313451200621895 1525 10140899
SGTC_548 1436-0017 110 µM 0.485514248198814 0.312013444969432 no 1063 0.313655804096291 1622 9677137
SGTC_1752 st044819 83.042 µM 0.481979167685626 0.313207354883772 no 1064 0.31491037261581 1433 441209 YML126C ERG13
SGTC_899 1083-0020 478 µM 0.479359148183034 0.314093485409473 no 1065 0.315841575214467 1578 767123
SGTC_2808 7946468 45.46 µM 0.47756085920513 0.314702315433246 no 1066 0.316481397397864 1557 2970879
SGTC_1932 st074806 40.9 µM 0.476787669248543 0.314964242250579 no 1067 0.316756663580445 1589 17251235
SGTC_2099 5377090 177.372 µM 0.474897245955414 0.31560503628311 no 1068 0.317430107265487 1488 2243829
SGTC_725 1497-0963 19 µM 0.473567232855967 0.316056201508034 no 1069 0.317904273218184 1650 3549977
SGTC_1571 st070080 73.4 µM 0.471118294809286 0.316887643510414 no 1070 0.318778130604356 1624 4315245
SGTC_1362 1611-0397 101 µM 0.469448969345574 0.317454929109001 no 1071 0.319374376369048 1517 27816
SGTC_1953 st076800 12.1 µM 0.469400655365522 0.317471354005995 no 1072 0.319391640009819 1461 297591
SGTC_1860 st056228 74.6 µM 0.468446010390802 0.317795970290244 no 1073 0.319732835776454 1491 688679
SGTC_963 1269-2853 151 µM 0.465746654609394 0.31871461331642 no 1074 0.320698426595355 1497 3668223
SGTC_371 0195-0006 7.36 µM 0.461731198052668 0.320083213230583 no 1075 0.322137047712417 1455 3928593
SGTC_1773 st048542 73.5835 µM 0.461502168772227 0.320161348038459 no 1076 0.32221918288543 1454 3237138
SGTC_1638 st008370 60.6 µM 0.460959324378961 0.32034657473512 no 1077 0.322413894052624 1490 24207134
SGTC_121 0557-0495 61.343 µM 0.459624218408507 0.320802323407732 no 1078 0.322892986268877 1581 3104427
SGTC_609 0986-0026 86.3 µM 0.458875255714509 0.321058105923339 no 1079 0.323161874410409 1581 2848610
SGTC_2162 5663267 200 µM 0.455933381385005 0.322063623242799 no 1080 0.324218942086672 1631 6456493
SGTC_2950 9072895 21.46 µM 0.455899337920715 0.322075266767102 no 1081 0.324231182825939 1479 17332245
SGTC_420 mitomycin C 81.9 mM 0.454588106340626 0.322523866181991 no 1082 0.324702796469565 1505 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1947 st076332 61.6 µM 0.453726117465343 0.322818911260443 no 1083 0.325012983198007 1566 24208416
SGTC_2651 TUB2.036 5 µM 0.453227724628934 0.322989554112308 no 1084 0.325192385251105 1616 15992207 YFL037W TUB2
SGTC_1009 4106-0057 9.87 µM 0.452929645385659 0.323091630156872 no 1085 0.325299701565701 1556 2928005
SGTC_2262 9014885 67.46 µM 0.452027640388093 0.323400599297671 no 1086 0.325624535161827 1576 6457424
SGTC_327 1273-0057 3.96 µM 0.451978818496752 0.32341732602783 no 1087 0.32564212087485 1531 3108138
SGTC_2908 7930301 100 µM 0.451508922133076 0.323578334135559 no 1088 0.32581139803371 1454 2223178
SGTC_2190 6049624 200 µM 0.450971890968833 0.323762386163225 no 1089 0.326004904055389 1571 2265554
SGTC_2066 5222451 176 µM 0.450425208956873 0.323949790020502 no 1090 0.326201935664423 1495 2281147
SGTC_1666 st014829 29 µM 0.450284693245642 0.323997966343107 no 1091 0.326252587272621 1522 3858230
SGTC_2653 dihydrofissinolide 100 µM 0.44933113981767 0.324324973451545 no 1092 0.326596398693757 1578 6857746
SGTC_2260 7964312 200 µM 0.449218592327777 0.32436357890361 no 1093 0.32663698833039 1652 231951
SGTC_248 streptozotocin 5.23457 mM 0.44764740790441 0.324902715362542 no 1094 0.327203841511599 1642 5300 DNA alkylating agent.
SGTC_1811 st050069 61.5 µM 0.447632789386735 0.32490773328745 no 1095 0.327209117466552 1574 3877702
SGTC_2723 salbutamol 83.58 µM 0.447604805550667 0.324917339055043 no 1096 0.327219217181829 1583 9884233 β2-adrenoceptor agonist
SGTC_2529 gangaleoidin 93.61 µM 0.446503334252239 0.325295523917194 no 1097 0.327616852327228 1576 4565183
SGTC_894 0960-0238 55.9 µM 0.4437716750323 0.326234202021543 no 1098 0.328603834517433 1582 6741907 YDL195W SEC31
SGTC_1463 k081-0032 34.1 µM 0.442690035606494 0.326606189871408 no 1099 0.328994975391986 1473 977755
SGTC_2206 7254556 146.969 µM 0.442521364818636 0.326664213187559 no 1100 0.32905598677034 1620 4398905
SGTC_911 3456-4043 236 µM 0.442045212958478 0.326828033644044 no 1101 0.32922824437238 1653 914281
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.439507814142282 0.32770159024754 no 1102 0.330146810622233 1560 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2465 5809242 33.21 µM 0.438995601517843 0.327878045611809 no 1103 0.330332361709557 1631 2731748
SGTC_1530 rhein 70.4 µM 0.437295065881445 0.328464149315414 no 1104 0.330948686611906 1573 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2673 kobusone 100 µM 0.436766006795527 0.32864658012315 no 1105 0.331140527003348 1629 6710676 An epoxy ketone and protein crosslinker.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.436566247367551 0.328715472041176 no 1106 0.331212972651105 1559 2724 A muscle relaxant with antifungal properties.
SGTC_1956 st077085 54 µM 0.435825910333678 0.328970846101883 no 1107 0.331481521672522 1553 24208685
SGTC_2796 7949634 45.45 µM 0.435553323204086 0.329064893237732 no 1108 0.331580421455851 1547 2971588
SGTC_43 0570-0105 72.5 µM 0.435406643850251 0.32911550455549 no 1109 0.331633644368684 1615 1114046 YDL195W SEC31
SGTC_1456 k015-0012 13 µM 0.432194392348075 0.330224667380235 no 1110 0.332800067328981 1754 2989616
SGTC_789 1309-1135 70.6 µM 0.431996182614717 0.330293156517401 no 1111 0.332872093823171 1539 3092424
SGTC_989 1501-0895 10.3 µM 0.431481915211785 0.330470882326244 no 1112 0.333058999768467 1670 2830112
SGTC_409 arachidonic acid 100 µM 0.431106449666623 0.330600663718585 no 1113 0.333195485603404 1584 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2725 haloperidol 53.21 µM 0.431024681546465 0.330628929947086 no 1114 0.333225212140273 1553 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1124 fisetin 1.16336 µM 0.430320392872614 0.330872433815628 no 1115 0.333481297379043 1554 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2865 9030313 51.95 µM 0.429250656522683 0.33124242606893 no 1116 0.333870410898352 1523 42562754
SGTC_2797 7859098 81.82 µM 0.428984086094549 0.331334651081803 no 1117 0.333967402954965 1569 972681
SGTC_18 0111-0177 500 nM 0.428588625870385 0.331471486768031 no 1118 0.334111312192085 1615 721752
SGTC_526 4469-0568 170 µM 0.428202388803737 0.331605152808923 no 1119 0.334251888639373 1544 2901964
SGTC_3318 9139014 38.6185 µM 0.427884447318861 0.33171519971876 no 1120 0.33436762539168 1585 16643984
SGTC_481 bay k-8644 50 µM 0.427421302214596 0.331875530950225 no 1121 0.334536247197859 1531 2303 A calcium channel antagonist.
SGTC_1046 2001-0062 216 µM 0.426556482189286 0.332174996128849 no 1122 0.334851200098647 1561 739778
SGTC_1302 1159-0335 255 µM 0.425040445819423 0.332700219559843 no 1123 0.335403595324536 1567 649284
SGTC_1421 4029-0249 71.4 µM 0.424161510391722 0.333004872985373 no 1124 0.33572401444139 1706 2894095
SGTC_78 0336-0123 156.75 µM 0.423855613110132 0.333110927871115 no 1125 0.335835558448753 1539 6765896
SGTC_1514 1189-1591 158 µM 0.422606355505455 0.333544185192367 no 1126 0.336291244422389 1659 767698 YMR146C TIF34
SGTC_1780 st038448 24.544 µM 0.420838560911443 0.334157656719384 no 1127 0.336936485816008 1708 728868 YDL195W SEC31
SGTC_1483 3453-0561 55.9 µM 0.420408441425112 0.334306986684674 no 1128 0.337093551241412 1636 4546991
SGTC_1147 3809-1045 12.3 µM 0.419938485925157 0.334470176999328 no 1129 0.33726519593387 1559 325925
SGTC_421 streptovitacin 30 mM 0.418283364994231 0.335045160557104 no 1130 0.337869975322096 1600 91467 include heat shock
SGTC_2462 5162487 171.77 µM 0.416553956003117 0.335646364804179 no 1131 0.338502346924798 1636 2259986
SGTC_1725 st036284 20.55 µM 0.416304682612751 0.33573305587221 no 1132 0.338593533257315 1753 707914
SGTC_2432 5630864 12.22 µM 0.414739731543633 0.336277506399164 no 1133 0.339166221716054 1568 5714970
SGTC_1272 0839-0021 27 µM 0.412440372345431 0.337078082423576 no 1134 0.340008338474209 1623 5027250
SGTC_410 α-linolenic acid 100 µM 0.411166669736156 0.337521870048711 no 1135 0.340475163130513 1685 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_748 act1.228 77.9 µM 0.410833161179288 0.337638109562594 no 1136 0.340597437753181 1545 4421505 YNR035C ARC35
SGTC_2763 lisinopril 49.32 µM 0.409921288101426 0.337956008598507 no 1137 0.340931844319156 1628 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_628 1636-0253 16 µM 0.409296151691699 0.338174011726142 no 1138 0.341161169656637 1688 4456143
SGTC_463 ikarugamyin 104 µM 0.40866800637631 0.338393118809884 no 1139 0.341391657890792 1649 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2973 9094665 17.96 µM 0.406717735177049 0.339073752912649 no 1140 0.342107656564536 1730 25237061 YIL048W NEO1
SGTC_157 1348-1695 65.819 µM 0.406717572509269 0.339073809704775 no 1141 0.34210771630812 1598 5380510
SGTC_1500 4488-1866 171 µM 0.403845942115808 0.340076949478698 no 1142 0.343163005112878 1712 2900003
SGTC_3292 9120825 59.784 µM 0.402148621979934 0.340670403585253 no 1143 0.34378732561216 1767 24824900
SGTC_1156 4092-0367 4.88 µM 0.40091069942546 0.341103482045347 no 1144 0.344242936110112 1653 1357585
SGTC_2821 7996764 71.43 µM 0.399798062913339 0.341492908793711 no 1145 0.344652628791996 1661 2987135
SGTC_15 0266-0086 27.098 µM 0.399064200902697 0.341749855533509 no 1146 0.344922949712572 1693 1712902 YIL048W NEO1
SGTC_130 0136-0219 337.655 µM 0.397643325300029 0.342247554363623 no 1147 0.345446559704976 1720 234244
SGTC_355 1311-2252 105 µM 0.397566772209447 0.34227437687538 no 1148 0.345474778861985 1588 5338538
SGTC_1385 3091-4834 14.1 µM 0.395070919295768 0.34314930377541 no 1149 0.346395274933783 1698 4072814
SGTC_2643 anethole 100 µM 0.393939653874957 0.343546148879775 no 1150 0.346812796558123 1637 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1026 k007-1105 30.6 µM 0.38833585459636 0.345514484205991 no 1151 0.348883753512906 1648 7066794
SGTC_1699 st031318 29.054 µM 0.38701076820053 0.34598053471912 no 1152 0.349374118039888 1695 5340658
SGTC_1012 4112-3522 18 µM 0.385502502387762 0.346511295906795 no 1153 0.34993257641919 1767 3112398
SGTC_447 ml7 120 µM 0.382681691249822 0.347504752459018 no 1154 0.350977895621891 1734 4216 Selective myosin light chain kinase inhibitor.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.381425788576028 0.347947404336012 no 1155 0.351443664124691 1620 61125 An anti-inflammatory.
SGTC_2787 5284540 71.43 µM 0.381189040287443 0.348030871202807 no 1156 0.351531490450661 1641 736958
SGTC_3240 9133527 49.47 µM 0.377757423682275 0.349241530917976 no 1157 0.352805402530296 1643 17617455
SGTC_2952 9073731 13.78 µM 0.376335523475151 0.349743621965702 no 1158 0.353333736606116 1599 16457353
SGTC_675 1309-0189 238 µM 0.375038195156251 0.350201954501678 no 1159 0.353816030365583 1634 4246530
SGTC_1891 st059073 26.2 µM 0.372904172257123 0.350956357049937 no 1160 0.354609883315815 1799 688754
SGTC_1059 3448-6867 171 µM 0.372311015684737 0.351166149511882 no 1161 0.354830648946278 1784 3934407
SGTC_177 1327-0068 8.361 µM 0.372119329585738 0.351233956319409 no 1162 0.354902002598582 1640 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1172 0370-0043 85 µM 0.371858557614247 0.351326209082928 no 1163 0.354999081098651 1709 376585
SGTC_2485 5633444 17.78 µM 0.371716995220769 0.351376292988248 no 1164 0.355051784972158 1614 5724239
SGTC_1161 k007-0610 110 µM 0.371014987464156 0.351624697137083 no 1165 0.355313184384378 1707 5843850
SGTC_1499 4480-0877 67.3 µM 0.370597769779739 0.351772358873387 no 1166 0.355468571711709 1678 2861909
SGTC_849 0386-0493 241 µM 0.368850431151907 0.352391019909277 no 1167 0.356119606140613 1660 726119
SGTC_798 1287-0182 476 µM 0.368805508802001 0.35240693023208 no 1168 0.356136349134119 1808 1649755
SGTC_508 roscovitine 141 µM 0.368680611105235 0.352451167090642 no 1169 0.356182901169177 1729 160355 A CDKinase inhibitor.
SGTC_2666 tannic acid 100 µM 0.368588878213609 0.352483658752532 no 1170 0.356217093339545 1702 16134267 A thiamine antagonist.
SGTC_608 k048-0125 159 µM 0.367815096049122 0.352757774126711 no 1171 0.356505555952473 1770 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2524 avocatin b 10.57 µM 0.36547502601556 0.353587217881762 no 1172 0.357378422873637 1773 6710748
SGTC_2528 xanthyletin 44.79 µM 0.364811520660342 0.353822525796986 no 1173 0.357626052347209 1663 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_393 acivicin 6.25 µM 0.363043164802035 0.354449934435401 no 1174 0.358286320007451 1680 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1494 4358-1428 177 µM 0.362521817017734 0.354634982946668 no 1175 0.358481061546849 1824 1564571
SGTC_679 0422-0091 41.4 µM 0.361106095580502 0.355137655702494 no 1176 0.359010068330076 1623 627384 YHR062C RPP1
SGTC_1301 naphtanilide LB 4.81 µM 0.361001084070005 0.355174951644571 no 1177 0.359049318335679 1794 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2807 7945238 51.95 µM 0.358602352891149 0.356027263413449 no 1178 0.359946293183055 1714 17148797
SGTC_2090 5301565 104.445 µM 0.357066734268372 0.356573274255947 no 1179 0.360520923663349 1702 2056344
SGTC_888 0916-0002 6.97 µM 0.35654386084822 0.356759256438063 no 1180 0.360716655561244 1773 2802138 YIL048W NEO1
SGTC_2181 6316240 54.2555 µM 0.355302776182749 0.357200837294378 no 1181 0.361181387941176 1628 12779990
SGTC_1294 1000-1494 117 µM 0.353507306239569 0.357840008233249 no 1182 0.361854076163067 1652 712797 YDL207W GLE1
SGTC_281 1672-3440 14.9 µM 0.353507173724816 0.357840055422033 no 1183 0.361854125826642 1757 6833000
SGTC_542 3381-0244 89.3 µM 0.353313821457998 0.357908910886638 no 1184 0.361926592423118 1810 1112843
SGTC_703 3875-0075 71.8 µM 0.351832577040925 0.358436556102938 no 1185 0.362481912849587 1745 2850814
SGTC_3321 9137793 26.8275 µM 0.351061045481762 0.3587114963284 no 1186 0.362771275744372 1696 4904192
SGTC_3012 9080433 71.4286 µM 0.350859970638342 0.358783162675551 no 1187 0.362846701742647 1819 17688859
SGTC_1614 st002383 48.6 µM 0.348407231527029 0.359657758352934 no 1188 0.363767186188401 1709 1947235
SGTC_723 4182-0001 115 µM 0.348039329359915 0.359789008150954 no 1189 0.363905323580929 1669 744821 YLR208W SEC13
SGTC_1660 st012960 28.1 µM 0.346748053667659 0.360249803996739 no 1190 0.364390302844591 1710 24207266
SGTC_867 0518-0118 155 µM 0.346505148458725 0.360336508210231 no 1191 0.364481557840887 1730 6848158
SGTC_1117 retinoic acid 1.10837 µM 0.346292633327273 0.360412370677254 no 1192 0.364561402146774 1842 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1342 1486-1464 234 µM 0.345563038362882 0.360672859223716 no 1193 0.364835563811686 1702 3253938
SGTC_3094 9117742 49.47 µM 0.345316898744249 0.360760753468307 no 1194 0.364928071893252 1646 17149698
SGTC_1523 st012844 44.7 µM 0.34474441389551 0.360965211101378 no 1195 0.365143262601025 1711 4274103
SGTC_1691 st019933 84.6 µM 0.344027908495059 0.361221160315494 no 1196 0.365412648876646 1825 6176082
SGTC_2947 9072639 7.68 µM 0.34335757758636 0.36146067139595 no 1197 0.365664734948334 1643 16488146
SGTC_3041 9091929 49.47 µM 0.342757896751491 0.361674985032563 no 1198 0.365890301381605 1757 25236887
SGTC_2100 5377183 190 µM 0.342397625383672 0.361803759505622 no 1199 0.366025837647273 1818 2844202
SGTC_1256 0570-0116 285 µM 0.342094985735628 0.361911946340458 no 1200 0.366139705434475 1665 410638
SGTC_2015 5119600 184 µM 0.341162019962879 0.362245529935038 no 1201 0.366490806786081 1831 2828786
SGTC_1453 4237-0541 195 µM 0.340937839223879 0.362325701765043 no 1202 0.366575188990795 1849 739892
SGTC_1221 2958-7315 257 µM 0.33995720777636 0.362676467498555 no 1203 0.366944376943622 1735 4562705
SGTC_2893 9048488 25.97 µM 0.337357391650197 0.363606962701606 no 1204 0.367923750202133 1637 6467338
SGTC_517 1365-0151 113 µM 0.337185795725495 0.363668406653828 no 1205 0.367988422169699 1738 768657
SGTC_2135 5326629 150.42 µM 0.335381152094071 0.364314813786051 no 1206 0.36866879197127 1694 5020077
SGTC_1650 st011916 45.8 µM 0.335215750817196 0.364374078380927 no 1207 0.368731170644544 1826 242528
SGTC_3235 9132602 49.47 µM 0.334350617247206 0.364684115435234 no 1208 0.369057499443922 1752 4912240
SGTC_1054 3429-0080 167 µM 0.333908516640691 0.36484258477796 no 1209 0.369224296468004 1789 1162877
SGTC_2412 st077135 33.4 µM 0.332712293322466 0.365271482348169 no 1210 0.369675734511064 1793 13258915
SGTC_757 1066-0008 322 µM 0.332209520658675 0.365451798341892 no 1211 0.369865527593206 1793 6842497
SGTC_226 1,3-diallylurea 8.28947 mM 0.331663518880393 0.365647651850477 no 1212 0.370071675264277 1758 74537 YKL182W FAS1
SGTC_827 3253-0474 693 µM 0.331256469138817 0.36579368537867 no 1213 0.370225384692438 1850 5402065
SGTC_2318 6029776 164 µM 0.32933053901071 0.366484897179856 no 1214 0.370952931795296 1790 818325
SGTC_1223 0764-0573 147 µM 0.328875065953471 0.366648428829055 no 1215 0.371125060709434 1731 1609797
SGTC_2335 9018011 154.17 µM 0.328579318773797 0.366754625954602 no 1216 0.371236841043973 1832 6458208
SGTC_2467 5474540 200 µM 0.327656176678214 0.367086174104799 no 1217 0.371585820822482 1702 5413519
SGTC_2592 piperlongumine 83.33 µM 0.326811415389205 0.367389658532841 no 1218 0.371905262447826 1666 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_220 paclitaxel 373.376 µM 0.326245988184777 0.367592837188755 no 1219 0.372119124783722 1790 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1841 st054148 70 µM 0.324596197492773 0.368185878938276 no 1220 0.372743352746788 1699 675442
SGTC_192 3455-0609 60.9 µM 0.323967767576962 0.368411860122542 no 1221 0.372981218525962 1764 3769639
SGTC_2661 dactinomycin 12.96 µM 0.322699229690992 0.36886816050678 no 1222 0.373461517790026 1762 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_308 4092-1169 104 µM 0.321166862034405 0.369419608524617 no 1223 0.374041971607966 1744 2268590 YDL196W YDL196W
SGTC_320 4092-0846 5.34 µM 0.320997553781262 0.369480553427037 no 1224 0.374106122346922 1814 1359356
SGTC_163 TUB2.036 7.546 µM 0.320802832835895 0.369550650042819 no 1225 0.374179906241901 1800 15992207 YJR013W GPI14
SGTC_1979 st071809 45.3 µM 0.317648251591051 0.370686854533848 no 1226 0.375375884385437 1816 4976333
SGTC_3002 9075603 71.4286 µM 0.316969048202072 0.3709316353087 no 1227 0.375633544075766 1770 20105405
SGTC_2571 chrysanthemic acid 100 µM 0.316773144517745 0.371002247517171 no 1228 0.375707871571833 1671 2743 An insecticide.
SGTC_2968 9090663 33.37 µM 0.313972058202903 0.372012354867647 no 1229 0.376771130386129 1761 25236811
SGTC_3137 9097352 49.47 µM 0.313004132272288 0.372361606553205 no 1230 0.37713876134471 1831 44120435
SGTC_1062 mesoridazine 14.2 µM 0.311625399602569 0.372859268747192 no 1231 0.377662614359965 1758 4078 A neuroleptic.
SGTC_843 0310-0051 143 µM 0.310743832746609 0.373177587136393 no 1232 0.377997685995788 1781 2065037
SGTC_1783 st039459 87.517 µM 0.310171811989295 0.373384180170208 no 1233 0.378215152471605 1894 729761
SGTC_397 arbidol 50 µM 0.308697281124755 0.373916894658353 no 1234 0.378775906117848 1858 131410 A RNA synthesis inhibitor.
SGTC_300 r073-0011 5.04 µM 0.308393935149896 0.374026516576901 no 1235 0.378891298143803 1828 2735780
SGTC_3356 9151811 4.48 µM 0.306910694642248 0.374562670471335 no 1236 0.379455674267826 1740 1859254 YPR165W RHO1
SGTC_269 exalamide 29 µM 0.306442170185147 0.374732080672525 no 1237 0.379634002266663 1788 3316 A derivative of salicylamide.
SGTC_1907 st060210 83.7 µM 0.306000883014155 0.374891664462148 no 1238 0.379801986729611 1856 688793
SGTC_2301 7769476 200 µM 0.305361961628873 0.375122757168096 no 1239 0.380045244655656 1797 977820
SGTC_1346 1488-2224 62.4 µM 0.304422533942948 0.375462621977806 no 1240 0.380403001173458 1895 3722427
SGTC_213 1246-0773 967 nM 0.303861316898925 0.375665704426817 no 1241 0.380616774881809 1812 6251622
SGTC_2496 diffractaic acid 79.83 µM 0.303682308546346 0.375730487782166 no 1242 0.38068496879256 1897 94870 An apoptosis inducer which activates caspases.
SGTC_496 calpeptin 138 µM 0.303282566452995 0.375875167609407 no 1243 0.380837265438714 1746 73364 A calpain inhibitor.
SGTC_1856 st057054 55.7 µM 0.301649222916314 0.376466509551459 no 1244 0.381459740147739 1894 1266018
SGTC_2905 7799065 20.05 µM 0.300601553722467 0.376845964493399 no 1245 0.381859173265286 1884 1296806
SGTC_683 panaxydol 45 µM 0.30057622300853 0.376855140490644 no 1246 0.38186883238267 1869 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_111 0083-0039 52.457 µM 0.300232219001793 0.376979762095203 no 1247 0.382000015398958 1793 759313
SGTC_2983 9022671 12.99 µM 0.299806439013068 0.377134026259871 no 1248 0.382162401755945 1937 6405161
SGTC_2366 9070441 60.58 µM 0.299289348244833 0.377321399563234 no 1249 0.38235964060235 1726 6837235
SGTC_3289 9119912 71.43 µM 0.298884764952301 0.377468024737331 no 1250 0.382513985941979 1799 17014829
SGTC_1925 st057770 10.1 µM 0.298087299342095 0.377757086231398 no 1251 0.382818267423389 1659 5989122
SGTC_153 4077-0274 519.67 µM 0.297973468533419 0.377798352662706 no 1252 0.382861706682629 1927 3121976
SGTC_905 2-aminofluorene 215 µM 0.297831242314307 0.377849915079447 no 1253 0.382915984055903 1755 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1604 st002052 72.4 µM 0.296737858725371 0.378246380852936 no 1254 0.383333325520451 1802 6254834 YHR062C RPP1
SGTC_3170 9103054 49.47 µM 0.296365745305018 0.378381340108806 no 1255 0.383475391085554 1768 16432970
SGTC_749 1000-0129 128 µM 0.296159173633186 0.378456266572683 no 1256 0.383554262840162 1917 708470
SGTC_2951 9072950 58.06 µM 0.295673748856094 0.378632354979965 no 1257 0.383739623329212 1881 16488155
SGTC_105 0111-0055 734.78 µM 0.29534122902991 0.378752991483161 no 1258 0.383866612093264 1806 5179370
SGTC_3159 9100096 49.47 µM 0.29484260025407 0.378933913606869 no 1259 0.384057060955914 1773 25236875
SGTC_868 0527-0199 213 µM 0.294251080427548 0.379148574655539 no 1260 0.384283025416941 1791 2849450
SGTC_316 k060-0003 58.6 µM 0.293553187693649 0.379401886087392 no 1261 0.384549675601889 1877 6152314
SGTC_2251 lansoprazole 556 µM 0.292695846398889 0.379713142815951 no 1262 0.38487732251052 1715 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3255 9139072 49.47 µM 0.292468562833192 0.379795670922231 no 1263 0.384964196417092 1805 17646060
SGTC_2033 5192550 145 µM 0.291869509567701 0.380013217192336 no 1264 0.385193198385331 1767 182073
SGTC_224 benfluorex 43.875 µM 0.28922474218113 0.380974117816156 no 1265 0.38620469952125 1894 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2850 9015429 58.44 µM 0.289143286250462 0.381003724188968 no 1266 0.386235864965207 1749 6457570
SGTC_86 0417-1630 471.922 µM 0.287531577465865 0.381589666831934 no 1267 0.386852663460238 1903 3634867
SGTC_2626 ethyl orsellinate 100 µM 0.287153459523467 0.381727172359681 no 1268 0.386997410079973 1768 75653 A natural product.
SGTC_2263 7948595 193.29 µM 0.286536551452282 0.381951547806794 no 1269 0.387233601231963 1770 2971371
SGTC_2040 5100729 123 µM 0.286191270842556 0.382077147027486 no 1270 0.387365814563416 1835 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1565 sinapyl alcohol 95.1 µM 0.286032760332632 0.382134810943319 no 1271 0.387426515086945 1730 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1442 4112-3290 3 µM 0.285622190887196 0.382284182542744 no 1272 0.387583752661422 1814 704353
SGTC_2241 6772625 37.8075 µM 0.284734725124398 0.382607116333699 no 1273 0.387923692278045 1763 2285411
SGTC_2628 lathosterol 100 µM 0.283963119001288 0.382887957121936 no 1274 0.388219322228803 1809 6710616
SGTC_2881 9058953 51.95 µM 0.281869039969512 0.383650447140496 no 1275 0.38902196494398 1803 17122249
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.281672289201385 0.383722110673344 no 1276 0.389097402248153 1773 4174840
SGTC_2892 9047358 58.44 µM 0.281514841135889 0.383779461647899 no 1277 0.389157773296552 1797 6466771
SGTC_1383 3049-0032 20.7 µM 0.281351815760276 0.383838846858597 no 1278 0.389220285698854 1926 712864
SGTC_853 0419-0306 21 µM 0.281319866144458 0.383850485456496 no 1279 0.389232537178233 1766 762713
SGTC_3030 9087619 49.47 µM 0.279900358718999 0.384367688847564 no 1280 0.389776975999698 1779 25236973
SGTC_1390 3413-2614 145 µM 0.279745779483518 0.384424022880125 no 1281 0.389836276503794 1795 3421432
SGTC_565 1418-0001 44.5 µM 0.279548514900602 0.384495916478244 no 1282 0.38991195591086 1892 2862145
SGTC_1326 1431-2094 10.8 µM 0.278605774129428 0.384839555665511 no 1283 0.390273690496179 1759 616278
SGTC_972 1319-0219 195 µM 0.278479597021596 0.384885555454792 no 1284 0.390322112531727 1778 23903702
SGTC_1181 1222-0449 220 µM 0.278176412511918 0.384996092615517 no 1285 0.390438470315501 1886 658318
SGTC_3212 9128307 49.47 µM 0.277721487713504 0.385161969859559 no 1286 0.390613082211942 1640 27243542
SGTC_1921 5740136 50 µM 0.27770467069891 0.385168102177173 no 1287 0.390619537439889 1961 1774243
SGTC_1661 st013063 9.66 µM 0.273187260214759 0.386816409345941 no 1288 0.392354636260688 1809 721395
SGTC_2858 9025781 8.96 µM 0.272453701675322 0.387084262935563 no 1289 0.392636592912289 1935 4894980 YPL153C RAD53
SGTC_2512 diallyl trisulfide 49.23 µM 0.272349888448077 0.387122173930669 no 1290 0.392676499981848 1896 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.271134894470225 0.387565951013638 no 1291 0.393143642245998 1896 66535 A nucleotide analog.
SGTC_2199 6590217 200 µM 0.269699068013979 0.388090576644243 no 1292 0.393695888801688 1899 703109
SGTC_185 k048-0037 25.491 µM 0.268840793720698 0.388404272535903 no 1293 0.394026099862432 1961 6827589
SGTC_39 0986-0283 58.349 µM 0.268261423055205 0.388616071419199 no 1294 0.394249049088525 1954 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_660 4031-1742 102 µM 0.267230670186063 0.388992962641992 no 1295 0.394645781571877 1826 6738706
SGTC_860 0443-0016 25.1 µM 0.266747583396048 0.38916963763812 no 1296 0.394831757303087 1952 5337942
SGTC_731 3966-0296 387 µM 0.264457780597685 0.390007377828471 no 1297 0.395713596612017 1831 660956
SGTC_1361 1608-0041 5.61 µM 0.264096884679931 0.390139460824099 no 1298 0.395852632183142 1817 X1361
SGTC_2095 5432005 200 µM 0.262859673183222 0.390592359585086 no 1299 0.396329369832864 1829 783734
SGTC_2541 muurolladie-3-one 83.07 µM 0.259375848701332 0.391868458634954 no 1300 0.397672631091749 1874 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1097 itavastatin 7.23 µM 0.259157496652184 0.391948478280429 no 1301 0.397756861881276 1859 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1102 cgs 12066b 26.1 µM 0.258850875944303 0.39206085352489 no 1302 0.397875150952331 1868 6438352 A 5-HT1B full agonist.
SGTC_752 1896-0090 130 µM 0.258054399533173 0.392352800945249 no 1303 0.398182461893411 1818 772567
SGTC_1991 st073000 8.92 µM 0.256606702295405 0.39288360760167 no 1304 0.39874120026832 1935 4301969 YIL048W NEO1
SGTC_2369 9071472 200 µM 0.254870505575236 0.393520456987524 no 1305 0.399411558631298 1881 17296037
SGTC_944 3370-0224 231 µM 0.252854524590298 0.394260290705507 no 1306 0.400190315910352 1799 4580514
SGTC_230 MPP+ 141.667 µM 0.249974272389942 0.395317960135748 no 1307 0.401303622395599 1800 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2247 cerulenin 830 nM 0.248089876434907 0.396010355104516 no 1308 0.402032434125945 1951 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2695 st077686 51.995 µM 0.247696950300255 0.396154771750108 no 1309 0.402184445831822 1826 2876092
SGTC_1076 itraconazole 331 nM 0.2475652906071 0.396203165334975 no 1310 0.402235384452493 1965 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_906 1165-0455 526 µM 0.24713098633935 0.396362812015881 no 1311 0.402403426843473 1825 3252859
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.245111946046858 0.397105222433595 no 1312 0.403184876707229 1963 140250 A respiratory chain inhibitor.
SGTC_3138 9097216 49.47 µM 0.244846984753756 0.397202677666545 no 1313 0.403287456170163 2057 25237486
SGTC_391 gliotoxin 8.33 µM 0.244701636854942 0.397256140704939 no 1314 0.403343730270806 1919 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.24319663073112 0.39780983752736 no 1315 0.403926538406713 1889 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_644 1498-1197 63.3 µM 0.243103328241839 0.397844170617086 no 1316 0.403962676491811 1926 6741615
SGTC_3156 9099931 49.47 µM 0.241669291053537 0.398371961460032 no 1317 0.404518213250239 1864 18111053
SGTC_3300 9124615 50.48 µM 0.2410061398559 0.398616094174106 no 1318 0.404775178925842 1945 24824903
SGTC_384 k007-0144 5.16 µM 0.240240059517842 0.398898168647333 no 1319 0.405072079925847 1905 6824886
SGTC_2101 5377231 179.231 µM 0.238008846304611 0.399720012496797 no 1320 0.405937116490714 1956 2844213
SGTC_1834 st055981 52.8 µM 0.237356046910388 0.399960548473324 no 1321 0.406190292479059 1985 471719 YDL150W RPC53
SGTC_2869 9037858 32.47 µM 0.237260064354394 0.399995918219628 no 1322 0.406227520821932 1979 27187042
SGTC_2523 spermine 47.74 µM 0.23700955830482 0.400088234018234 no 1323 0.40632468752339 2008 1103 A DNA binding polyamine.
SGTC_876 0720-0963 56.8 µM 0.236431451480376 0.400301297653542 no 1324 0.406548946565998 2021 765861
SGTC_3291 9121177 71.43 µM 0.235860688424109 0.400511683825735 no 1325 0.406770386889113 1862 17015612
SGTC_2603 homopterocarpin 100 µM 0.229220042296503 0.402961566408652 no 1326 0.40934894787288 1875 101795 A weak amylase inhibitor.
SGTC_1879 gemcitabine 100 µM 0.226961890306837 0.403795523046675 no 1327 0.410226688006985 1924 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2887 9044784 58.44 µM 0.22636644776837 0.404015498593166 no 1328 0.410458210729296 2022 6465546
SGTC_2518 prenyletin 46.28 µM 0.226276563724918 0.404048707276711 no 1329 0.410493162571885 2012 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1358 1509-0022 2.48 µM 0.225892400304352 0.404190648618651 no 1330 0.410642554374264 1940 3258434
SGTC_3342 9147791 14.508 µM 0.225246558426644 0.404429303773449 no 1331 0.410893735766853 1920 1838168
SGTC_1214 0358-0031 63.7 µM 0.224510085957786 0.40470149265636 no 1332 0.411180209878004 2036 4301366
SGTC_1269 0831-0796 3.05 µM 0.224367297002605 0.404754270597182 no 1333 0.411235757616556 1993 927758
SGTC_3047 9092122 49.47 µM 0.223659218951482 0.405016017414842 no 1334 0.411511240309584 1882 17173831
SGTC_1983 st071813 46.9 µM 0.221359334831833 0.405866480926362 no 1335 0.412406326562897 1907 11838595
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.221331506112778 0.405876774309246 no 1336 0.412417159953815 2040 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_527 4476-4215 268 µM 0.219737440764186 0.406466501122493 no 1337 0.413037821856901 1909 4418754
SGTC_2502 avocadyne acetate 18.59 µM 0.216684362187921 0.407596583418155 no 1338 0.414227167824478 2022 3952079
SGTC_341 1486-1430 230 µM 0.216597345925116 0.407628803388551 no 1339 0.414261077143251 1880 2054753 YPL210C SRP72
SGTC_2221 6807166 181.081 µM 0.216377483766656 0.40771021569254 no 1340 0.41434675795172 1993 674925
SGTC_274 sirtinol 40.1 µM 0.215954678892389 0.407866786434096 no 1341 0.414511537474505 1848 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1436 4092-1007 8.32 µM 0.215833703624408 0.407911588028835 no 1342 0.414558687872173 1934 2881121
SGTC_504 lovastatin 124 µM 0.213880934392997 0.408634936555219 no 1343 0.415319954182333 1862 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1848 st056003 16.4 µM 0.213605906701284 0.408736837910597 no 1344 0.415427196414583 2101 146492
SGTC_2772 vinpocetine 57.06 µM 0.213172344987721 0.408897490720563 no 1345 0.415596269004198 1995 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1224 0823-0416 294 µM 0.212480435343479 0.409153903975545 no 1346 0.415866119823922 2013 3598164
SGTC_2246 7293507 91.5585 µM 0.212212247614513 0.40925330152989 no 1347 0.415970726062917 2062 887656
SGTC_659 k018-0002 107 µM 0.211895685004314 0.409370635618508 no 1348 0.416094208515675 2056 6797879 YHR007C ERG11
SGTC_3223 9129970 49.47 µM 0.209561514714938 0.410236046980263 no 1349 0.417004959711558 1933 17248386
SGTC_2378 9074213 121.43 µM 0.208200369493367 0.410740904055348 no 1350 0.417536260048717 2007 657714
SGTC_2208 7283366 200 µM 0.207862920566914 0.410866088835727 no 1351 0.4176680009401 2032 898663
SGTC_3194 9111903 49.47 µM 0.207571095633757 0.41097435562177 no 1352 0.41778193756412 1984 17087251
SGTC_2132 5317594 122.667 µM 0.205026814307548 0.411918568148821 no 1353 0.418775587613518 1943 794577
SGTC_2998 9066762 71.4286 µM 0.203930649432198 0.412325525320341 no 1354 0.419203846776296 2011 4945196
SGTC_1769 st044406 64.4 µM 0.203524394972833 0.412476373467884 no 1355 0.419362590121835 1903 670903
SGTC_2156 5649887 115 µM 0.20347783122258 0.412493664087079 no 1356 0.419380785679174 2047 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2355 9061122 103.12 µM 0.20310021461994 0.412633891555857 no 1357 0.4195283519915 2033 5302957
SGTC_885 0865-0106 16.8 µM 0.200369449750735 0.413648288620235 no 1358 0.4205958252757 1887 2793380
SGTC_223 busulfan 5 mM 0.198593259594897 0.414308399780658 no 1359 0.421290463328585 2019 2478 A DNA alkylator.
SGTC_1749 st037932 54.2 µM 0.198240592655592 0.414439495350078 no 1360 0.421428414655628 1930 594497
SGTC_3148 9097893 49.47 µM 0.198223535400012 0.414445836222015 no 1361 0.421435087119258 1866 17174100
SGTC_1785 bathophenanthroline 24 µM 0.197594448836836 0.414679708708255 no 1362 0.421681189180727 1881 72812 An iron chelator.
SGTC_982 1491-0518 27.5 µM 0.197330586994906 0.414777812364946 no 1363 0.421784422470997 1948 3091256
SGTC_2856 9022925 19.48 µM 0.197033483742365 0.414888281517613 no 1364 0.421900667562014 1968 4944862
SGTC_678 1218-2179 85.9 µM 0.196351711743126 0.41514180391957 no 1365 0.422167444467502 2024 6820081 YOR116C RPO31
SGTC_3181 9108277 49.47 µM 0.193394156447365 0.416242002497659 no 1366 0.423325145765526 1945 17097298
SGTC_3216 9129716 49.47 µM 0.191714371943341 0.416867168459372 no 1367 0.423982973814883 1949 8056934
SGTC_161 4065-0411 162.148 µM 0.19129198473319 0.417024401597839 no 1368 0.424148420198938 1975 1906281 YLR208W SEC13
SGTC_3325 9138760 55.175 µM 0.189280620370307 0.417773311261965 no 1369 0.424936441738653 1922 43844959
SGTC_572 0960-0087 17.7 µM 0.187964918954984 0.418263359950297 no 1370 0.425452075794973 1943 6796365
SGTC_3248 9135562 49.47 µM 0.18792854852541 0.418276908356731 no 1371 0.425466331476765 1949 17650701
SGTC_3347 9188721 44.724 µM 0.187526058681067 0.418426846957827 no 1372 0.42562409710326 2011 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1714 st033236 13.627 µM 0.187383417817408 0.418479987471371 no 1373 0.42568001149795 2022 2916566
SGTC_2449 5812982 45.77 µM 0.186439334589662 0.418831740893756 no 1374 0.426050124299017 2037 776185
SGTC_701 4424-0219 185 µM 0.186331459877563 0.418871937778557 no 1375 0.42609241901619 2101 2911779
SGTC_2000 st075254 36.4 µM 0.185656253880275 0.419123556078531 no 1376 0.426357168071579 1964 17234175
SGTC_93 0109-0045 59.227 µM 0.18500712964238 0.419365486094962 no 1377 0.426611721731938 2096 88733
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.184683555968857 0.419486094099314 no 1378 0.426738622368262 2046 23847180
SGTC_1067 clotrimazole 1.36 µM 0.183705153093953 0.419850827398872 no 1379 0.427122383064284 1963 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1168 k815-0004 80.5 µM 0.183557829190435 0.419905753419667 no 1380 0.427180174164698 1974 642433
SGTC_2249 haloperidol 116.36 µM 0.181846008506283 0.420544076923239 no 1381 0.427851788428724 1979 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3106 9121286 49.47 µM 0.181228521956063 0.42077438383258 no 1382 0.428094103990098 2082 15943471
SGTC_2576 guaiol 23.12 µM 0.180858589186342 0.420912372420492 no 1383 0.428239286895264 2112 227829
SGTC_1103 duloxetine 36.1 µM 0.180773015576059 0.420944293609323 no 1384 0.428272872288047 2077 60835 A selective serotonin reuptake inhibitor.
SGTC_1428 4049-0204 61.7 µM 0.179385372987413 0.421461992895139 no 1385 0.428817557882884 2078 X1428
SGTC_2196 6573537 42.6665 µM 0.178628986766942 0.421744241392206 no 1386 0.429114516198611 2097 2903087
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.17827713938339 0.421875548339153 no 1387 0.429252665670146 2058 5355888
SGTC_2367 9070478 135.38 µM 0.177939133272851 0.422001698001414 no 1388 0.429385388661161 1973 572802
SGTC_801 0866-0028 10.1 µM 0.177838047730206 0.422039426410285 no 1389 0.429425082913757 1947 6849771
SGTC_2557 derrustone 83.84 µM 0.17781798219421 0.422046915605383 no 1390 0.429432962329696 1901 629853 An antioxidant.
SGTC_2714 st079313 56.9 µM 0.177671952718529 0.422101420018681 no 1391 0.429490306622232 1983 2939799
SGTC_1352 1496-0991 99 µM 0.177452201489542 0.42218344333846 no 1392 0.429576603502574 1970 3000039
SGTC_677 0929-0063 136 µM 0.17734880326952 0.42222203844415 no 1393 0.429617209417534 2088 1539583
SGTC_1335 1486-0900 202 µM 0.175569461157852 0.422886324196986 no 1394 0.430316098046951 2099 X1335
SGTC_2885 9057732 51.95 µM 0.174303327419766 0.423359146399422 no 1395 0.430813542185735 1999 6471414
SGTC_1709 st033179 39.1045 µM 0.174251431133064 0.423378528794449 no 1396 0.430833933772548 2079 573381
SGTC_1504 k297-0033 30 µM 0.173825214043705 0.423537720758742 no 1397 0.43100141405146 1919 4388117
SGTC_2841 9004761 38.96 µM 0.172355092283734 0.424086906441186 no 1398 0.431579187471597 1859 2991039
SGTC_630 4356-0227 183 µM 0.172067094671193 0.424194509505471 no 1399 0.431692390772289 2058 779312
SGTC_872 0588-0139 234 µM 0.171448134915805 0.424425787363599 no 1400 0.431935704426044 2102 2047100
SGTC_1911 st060208 74.3 µM 0.169690561211161 0.425082656453903 no 1401 0.432626748739102 2067 688783
SGTC_3282 9108498 15.4605 µM 0.168911760615637 0.425373789133369 no 1402 0.432933024243749 1971 16459645
SGTC_2317 5986382 200 µM 0.16713407603263 0.426038478691245 no 1403 0.433632277150306 2060 877883
SGTC_485 niflumic acid 177 µM 0.1670102010796 0.426084804317623 no 1404 0.43368101117913 2069 4488 A COX2 inhibitor.
SGTC_2937 9044753 11.33 µM 0.16644337197022 0.426296794906913 no 1405 0.433904022025123 2056 6465530 YGL099W LSG1
SGTC_1130 3454-2858 15.9 µM 0.165908395199937 0.426496892455112 no 1406 0.434114520323417 1920 715628 YIL048W NEO1
SGTC_821 1114-0266 29.2 µM 0.16567122007263 0.426585609207443 no 1407 0.434207848040297 2008 3123235
SGTC_1791 st048313 56.1 µM 0.16526273019505 0.426738415956036 no 1408 0.434368596203175 2124 1204976
SGTC_531 3788-1495 174 µM 0.163693669426135 0.427325467852857 no 1409 0.434986150695229 1965 2896655
SGTC_2445 5742597 35.57 µM 0.163685508787564 0.427328521514258 no 1410 0.434989362993805 1988 1774255
SGTC_2269 7935389 174.42 µM 0.161670011683946 0.428082841175782 no 1411 0.435782860518655 1935 97605
SGTC_2319 6033012 152.6 µM 0.161412444320167 0.428179257302296 no 1412 0.435884283019943 2011 847246
SGTC_1989 st071868 50.2 µM 0.161124636443007 0.428286998542158 no 1413 0.435997618339774 2131 16414057
SGTC_3162 9099653 49.47 µM 0.160765197443807 0.42842156248866 no 1414 0.436139168523403 2120 25237511
SGTC_1037 k284-1091 78.7 µM 0.160743757095413 0.428429589420901 no 1415 0.436147612176544 2102 3334711
SGTC_2778 tioconazole 65.09 nM 0.160627840022485 0.428472987478868 no 1416 0.436193263223913 2071 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1905 st060207 84.5 µM 0.157776157676745 0.429540896625353 no 1417 0.437316593366429 1984 1948547
SGTC_340 k038-0059 454 µM 0.156789817352238 0.429910385658017 no 1418 0.437705249085166 2050 23733424
SGTC_2729 fluphenazine 10.66 µM 0.156462423255757 0.430033043047704 no 1419 0.437834268155427 2097 3372 An atypical antipsychotic.
SGTC_1287 0971-0001 34.6 µM 0.155892398527633 0.430246617511163 no 1420 0.438058918575252 2040 4665869
SGTC_2760 etidronate 98.04 µM 0.155312340508583 0.430463972156508 no 1421 0.438287543673353 2032 3305 A chelator and antioxidant.
SGTC_1131 3454-3128 32.3 µM 0.154335869077158 0.430829915181391 no 1422 0.438672458342099 2057 710982
SGTC_1338 1486-1223 76 µM 0.153897171712836 0.430994341027492 no 1423 0.438845407092173 2095 3444526
SGTC_1807 st050092 58.9 µM 0.152029777857251 0.43169438255762 no 1424 0.439581724650117 2042 5008496
SGTC_2922 7999257 32.47 µM 0.151743410372198 0.431801753944694 no 1425 0.439694658539018 2120 2988377
SGTC_2456 5770359 74.46 µM 0.151456874743428 0.431909193418835 no 1426 0.439807663650153 2118 3118787
SGTC_2601 securinine 100 µM 0.150309547227294 0.432339446024404 no 1427 0.440260200483467 2017 442872 A GABA receptor antagonist.
SGTC_2894 9048625 32.47 µM 0.150197643786843 0.432381414584816 no 1428 0.44030434239718 2148 4092861
SGTC_1665 st014639 11.4 µM 0.14918995981278 0.432759373343627 no 1429 0.440701871119926 2136 981133 YIL048W NEO1
SGTC_1630 st005209 31.3 µM 0.149141313452974 0.432777621018282 no 1430 0.440721063498574 2184 3367314
SGTC_733 4069-0007 56.1 µM 0.148781251231134 0.432912687958797 no 1431 0.440863122657736 2100 5717425 YNL287W SEC21
SGTC_1200 1643-0193 18.4 µM 0.148716719196053 0.432936896116174 no 1432 0.440888583969255 2150 5403974
SGTC_1198 1612-1005 86.7 µM 0.148264098077431 0.433106696733602 no 1433 0.441067173875437 2129 6998509
SGTC_75 0159-0059 199.013 µM 0.146795302290129 0.433657799749823 no 1434 0.441646796372431 2130 5377270
SGTC_1744 st037937 38.9 µM 0.145576430419165 0.434115227461953 no 1435 0.442127887769358 2087 1016152
SGTC_1292 0kpi-0043 232 µM 0.14545512057699 0.434160758400614 no 1436 0.44217577371244 2039 3333905
SGTC_188 3229-0966 278.469 µM 0.145274023903714 0.434228730615496 no 1437 0.442247261528557 2154 5722370
SGTC_3003 9075612 71.4286 µM 0.14470519279874 0.434442246402603 no 1438 0.442471819527854 2065 6501993
SGTC_3096 9117468 49.47 µM 0.143485436618096 0.43490015706891 no 1439 0.442953406066388 2157 41316311
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.141108462520434 0.43579275118157 no 1440 0.443892129211358 2129 2333 A French combination drug.
SGTC_738 1315-0003 72.4 µM 0.140380382442446 0.436066223271655 no 1441 0.4441797284528 2145 6251474
SGTC_1632 st005650 90 µM 0.139646284723928 0.436341986579319 no 1442 0.444469734486678 2061 2759605
SGTC_375 3970-0961 9.27 µM 0.139059042423164 0.43656260603395 no 1443 0.444701746553638 2096 2898222
SGTC_923 1900-2434 73.3 µM 0.137656619932886 0.437089558020215 no 1444 0.445255902596089 2148 5910570
SGTC_1605 st000082 49.1 µM 0.1363966936407 0.43756306312178 no 1445 0.445753843672483 2127 1114022
SGTC_625 k213-0058 121 µM 0.135280848821834 0.437982494267996 no 1446 0.446194913151604 2085 3655420
SGTC_1018 4259-0013 28.1 µM 0.133865618992071 0.438514560414883 no 1447 0.446754418802699 2064 6801262
SGTC_1414 3917-0015 5.4 µM 0.133075413669602 0.438811692381407 no 1448 0.447066869617899 2144 6618702
SGTC_2026 5148700 152 µM 0.131465653934196 0.439417098632633 no 1449 0.447703477456393 2083 79838
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.130808776279087 0.439664181163211 no 1450 0.447963290094398 2087 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_433 pimozide 108 µM 0.129756777818866 0.440059936106527 no 1451 0.448379430014495 2021 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1298 1079-1278 263 µM 0.129476223198278 0.440165489053486 no 1452 0.448490418856832 2082 2840950
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.128188406367759 0.440650058286472 no 1453 0.448999937376338 2168 165506
SGTC_298 1391-0729 10 µM 0.126920212698106 0.441127330746777 no 1454 0.44950177429796 2088 3237558
SGTC_1423 4048-0112 5.59 µM 0.125496817493037 0.441663113631312 no 1455 0.450065122197053 2185 X1423
SGTC_2514 salinomycin 42.74 µM 0.125468078494883 0.441673932434837 no 1456 0.450076497488264 2198 23682228 A polyether potassium ionophore.
SGTC_2682 pyrogallin 40.03 µM 0.125219904463023 0.441767359424862 no 1457 0.450174729892955 2182 822798 An ATP competetive kinase inhibitor.
SGTC_2972 9093619 59.92 µM 0.125021837137894 0.44184192569132 no 1458 0.450253131219532 1964 25236256
SGTC_3032 9089427 49.47 µM 0.124212616975015 0.442146593619986 no 1459 0.450573466351551 2083 17173707
SGTC_1319 1306-0155 43.7 µM 0.123988578377192 0.442230949250333 no 1460 0.450662159206608 2137 3122360
SGTC_580 1123-0028 41 µM 0.123140558298795 0.442550271799284 no 1461 0.45099789739294 2174 1677248 YPR107C YTH1
SGTC_2431 5490079 200 µM 0.122302521311113 0.442865871879623 no 1462 0.451329717636545 2088 5722345
SGTC_229 benomyl 22.8748 µM 0.119278450129862 0.444005020346316 no 1463 0.452527377953132 2105 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3245 9134821 49.47 µM 0.119041698334852 0.444094222903936 no 1464 0.452621160072874 2140 17014901
SGTC_344 k064-0035 6.43 µM 0.118733068409361 0.444210511717488 no 1465 0.452743418525113 2028 5088750
SGTC_2917 7979103 53.79 µM 0.118099648436715 0.444449193358201 no 1466 0.452994351005219 2156 2980565
SGTC_2726 cimetidine 79.27 µM 0.117625465879662 0.444627885270008 no 1467 0.453182213081236 2203 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_709 3807-1509 243 µM 0.117109781717421 0.444822229504245 no 1468 0.453386529193763 2196 1886677 YPL242C IQG1
SGTC_2704 st078022 71.1 µM 0.117051677688504 0.444844127815368 no 1469 0.453409551015194 2210 54697681
SGTC_557 1315-0110 16.2 µM 0.116142601804959 0.445186763224187 no 1470 0.453769762946847 2191 6833801
SGTC_1307 1187-1599 12.2 µM 0.115788791251813 0.445320127339003 no 1471 0.453909967023213 2102 1538471
SGTC_2362 9071156 126 µM 0.115690794163762 0.445357067114308 no 1472 0.453948801226295 2176 653133
SGTC_2493 resveratrol 26.09 µM 0.11488166726567 0.445662083724782 no 1473 0.454269458139427 2168 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_612 0302-0167 22.4 µM 0.111855525806434 0.446803132092377 no 1474 0.455468980246057 2176 235821
SGTC_615 k087-0205 167 µM 0.111846458824502 0.446806551589617 no 1475 0.455472574892359 2132 9642773
SGTC_1506 4226-2149 212 µM 0.111065397777482 0.44710113367519 no 1476 0.455782243755052 2110 991114
SGTC_1084 voriconazole 435 nM 0.110795226052779 0.447203037442508 no 1477 0.455889365551426 2207 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1481 3346-2004 36 µM 0.110033809665495 0.447490248324724 no 1478 0.456191280734247 2231 2770522
SGTC_1253 0550-0034 176 µM 0.10964945526469 0.44763523960496 no 1479 0.456343693730113 2110 5969915
SGTC_2414 st077232 92.9 µM 0.10883022539907 0.447944303721396 no 1480 0.456668574898093 1961 729801
SGTC_2137 5261020 140 µM 0.108131354200126 0.448207986100887 no 1481 0.456945748454198 2173 763655
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.106631317176751 0.448774023495087 no 1482 0.457540736353202 2200 91467 include heat shock
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.10660404660719 0.44878431498452 no 1483 0.457551554077031 2140 521171
SGTC_133 0724-0033 378.92 µM 0.106362353114939 0.448875527860333 no 1484 0.457647430729089 2227 280309
SGTC_3344 9148862 3.898 µM 0.105890695890653 0.449053534687062 no 1485 0.457834538083531 2194 4905352
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.105508141073022 0.449197921158769 no 1486 0.457986305202558 2060 803109
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.105168857194264 0.449325981644679 no 1487 0.458120911004288 2179 65057 A dermal irritant. YDR527W RBA50
SGTC_1637 st007924 17.4 µM 0.105030441669451 0.449378227197959 no 1488 0.458175826672773 2201 683336
SGTC_1820 st053765 18.6 µM 0.103060904237115 0.450121732492265 no 1489 0.458957316821453 2114 3690829
SGTC_780 0109-0199 192 µM 0.100682381472266 0.451019863960373 no 1490 0.459901298921952 2241 610414
SGTC_1768 st044301 37.178 µM 0.100656194118279 0.451029753723633 no 1491 0.45991169336079 2204 3931349
SGTC_3349 9149703 23.001 µM 0.100301536451331 0.451163694659347 no 1492 0.460052468866884 2224 4910494
SGTC_2234 tolnaftate 200 µM 0.0990735115738162 0.451627516590059 no 1493 0.460539951648683 2244 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_759 3486-0358 89.3 µM 0.0975668476791418 0.452196669936453 no 1494 0.461138125294011 2255 875103
SGTC_345 1362-0200 395 µM 0.0956290944061058 0.452928814741509 no 1495 0.461907578547359 2105 1419823
SGTC_2304 7443016 91.4 µM 0.0951592335881893 0.453106367303667 no 1496 0.462094174939438 2215 939854
SGTC_1013 4112-3890 241 µM 0.0945864389124365 0.453322829530678 no 1497 0.4623216608594 2089 705171
SGTC_2152 5568786 200 µM 0.0937839809424663 0.453626106078506 no 1498 0.462640378474964 2229 5399883
SGTC_3072 9116419 49.47 µM 0.0928488934104873 0.453979542021013 no 1499 0.463011803710607 2150 17170162
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.092717935842035 0.45402904309631 no 1500 0.463063823824575 2206 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1142 3253-1408 9.78 µM 0.09237152402936 0.454159987859767 no 1501 0.4632014316061 2264 256655
SGTC_1564 D-Arginine 115 µM 0.0921125687007867 0.454257877050238 no 1502 0.463304301264736 2119 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2424 5537928 59.2 µM 0.0916402456859945 0.454436429736135 no 1503 0.46349193726653 2159 5382802
SGTC_874 0599-0792 117 µM 0.0906879405892156 0.454796458432212 no 1504 0.463870276579618 2243 765305
SGTC_206 4546-0025 72.014 µM 0.0896149145447337 0.455202171400946 no 1505 0.464296616001578 2136 6620745 YIL048W NEO1
SGTC_2927 9011802 47.9 µM 0.0887799355642292 0.455517910721385 no 1506 0.464628401907473 2126 43912568
SGTC_3331 9141060 1.957 µM 0.0886186275281459 0.455578911057946 no 1507 0.464692501851395 2119 4906567 YPR165W RHO1
SGTC_405 ebelactone b 50 µM 0.0885043235569815 0.455622136945242 no 1508 0.464737924062296 2118 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_284 0988-0104 32.6 µM 0.0883268509678734 0.455689252103448 no 1509 0.464808449183599 2228 4666532
SGTC_2214 7179297 48.276 µM 0.0882488449805496 0.455718752181315 no 1510 0.464839448020325 2253 769744
SGTC_419 nsc-638432 893 µM 0.0881710666846691 0.455748166394561 no 1511 0.4648703565871 2142 368090
SGTC_2675 theaflavin digallate 100 µM 0.0880081736957728 0.455809770087098 no 1512 0.464935089841672 2219 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1942 st076330 65.2 µM 0.0875178908165804 0.455995194145639 no 1513 0.465129932589326 2196 24208414
SGTC_2380 9035439 200 µM 0.0867757026179949 0.456275906543318 no 1514 0.465424900628841 2215 6462575
SGTC_104 0074-0074 590.992 µM 0.0847753482004576 0.45703259420932 no 1515 0.466219996129081 2268 3943124
SGTC_1649 st011737 51.3 µM 0.0842375636758383 0.45723605230724 no 1516 0.466433776407746 2150 1761035
SGTC_1746 st038117 42 µM 0.0837129144277784 0.45743455178509 no 1517 0.466642344480379 2172 2898218
SGTC_2193 5925765 200 µM 0.0830196687517276 0.457696855496487 no 1518 0.466917950098747 2229 877370
SGTC_2642 cholecalciferol 100 µM 0.0822035629658536 0.458005669455383 no 1519 0.467242420100001 2257 9821465 A vitamin D precursor, similar to steriods.
SGTC_3259 9138485 49.47 µM 0.0814251801754224 0.458300232678912 no 1520 0.467551912355053 2258 17646153
SGTC_3146 9095609 49.47 µM 0.0808001441695131 0.458536781499907 no 1521 0.46780044670774 2207 17173999
SGTC_403 arphamenine a 50 µM 0.0781579169380621 0.459536910324063 no 1522 0.468851218494695 2247 5487158 An arginine aminopeptidase inhibitor.
SGTC_3200 9114385 49.47 µM 0.0774530823359537 0.459803745977086 no 1523 0.469131556984913 2169 17018030 YLR208W SEC13
SGTC_407 eburnamonine 100 µM 0.0773912669151956 0.459827148869116 no 1524 0.469156143969725 2225 3195
SGTC_3087 9117406 49.47 µM 0.0773130633482348 0.459856756399707 no 1525 0.469187249482018 2149 42546093
SGTC_642 0335-0876 158 µM 0.0769586441361465 0.459990940761266 no 1526 0.469328222275689 2206 6812350
SGTC_2755 lomerizine 42.69 µM 0.0755176505794032 0.460536552764467 no 1527 0.469901427252164 2222 3949 A calcium channel blocker.
SGTC_123 0083-0120 66.675 µM 0.0747638901689214 0.460821983239725 no 1528 0.470201286423362 2183 16001701
SGTC_2298 7976326 193.81 µM 0.0746407905611726 0.460868599946228 no 1529 0.470250259225866 2238 2235818
SGTC_2833 9001315 45.46 µM 0.073706770406464 0.461222322393189 no 1530 0.47062185572012 2130 2989378
SGTC_1365 1672-3266 55.4 µM 0.0736558358751565 0.461241612676467 no 1531 0.470642120575178 2272 6415873
SGTC_1398 3558-0053 112 µM 0.0733682691921158 0.461350523659033 no 1532 0.470756533520023 2205 4532369
SGTC_521 r062-0005 13.8 µM 0.0732896494971791 0.461380300034144 no 1533 0.470787814027467 2245 2832033
SGTC_1496 4469-0713 57.4 µM 0.0731962183897828 0.461415686356047 no 1534 0.470824987802787 2276 746691
SGTC_268 camptothecin 39.6153 µM 0.0721740286362681 0.461802852850261 no 1535 0.471231706702297 2284 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1081 sertraline 6 µM 0.0721164443675624 0.461824664655595 no 1536 0.471254619793529 2278 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1704 st028805 70.8 µM 0.0720681591252781 0.461842954258386 no 1537 0.47127383282532 2164 2876101
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0714221959593792 0.462087641519766 no 1538 0.471530872448208 2271 6312947
SGTC_140 0062-0056 502.533 µM 0.071056319753645 0.462226239766836 no 1539 0.471676466020116 2277 3758964
SGTC_2939 9044578 71.43 µM 0.0703422395831076 0.462496755002857 no 1540 0.471960631712319 2270 2653634
SGTC_2119 5528445 120.635 µM 0.0699783993728889 0.462634595393486 no 1541 0.472105426142618 2244 791935
SGTC_3010 9080089 71.4286 µM 0.0698907484182067 0.462667802515022 no 1542 0.472140308408093 2274 17027233
SGTC_2007 4011539 71.82 µM 0.0696331035924617 0.462765414401111 no 1543 0.472242844011949 2252 45595301
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0695949954623839 0.462779852321684 no 1544 0.472258010163242 2245 368090
SGTC_1252 0493-0875 34.8 µM 0.0695766395173841 0.462786806804685 no 1545 0.472265315417671 2249 3960963
SGTC_3314 9135860 59.4275 µM 0.0694293905071976 0.462842595176802 no 1546 0.472323917558677 2268 25252478
SGTC_3126 9127922 49.47 µM 0.0674007571756242 0.463611259332306 no 1547 0.473131333211226 2214 45595682
SGTC_1609 st001574 46.4 µM 0.0666997598368011 0.463876904133296 no 1548 0.473410362755201 2284 3960012
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.064230969853979 0.464812586097917 no 1549 0.47439315896197 2266 6708514
SGTC_369 0957-0393 4.5 µM 0.0641572737030851 0.46484052027138 no 1550 0.474422498956759 2229 6997992
SGTC_765 1319-0117 244 µM 0.0638370256381137 0.464961910779269 no 1551 0.474549998087068 2308 3487746 YGL099W LSG1
SGTC_2539 epi(13)torulosol 80 µM 0.0629906189775549 0.465282758158453 no 1552 0.474886987229317 2227 6708597
SGTC_3329 9141233 27.5565 µM 0.062815630918881 0.465349093705574 no 1553 0.47495665938845 2275 4909101 YNL103W MET4
SGTC_2331 7980721 200 µM 0.0621134205951261 0.465615301570822 no 1554 0.475236254773165 2249 2981221
SGTC_1663 st014140 55.4 µM 0.0609803665072061 0.466044874659291 no 1555 0.475687422604579 2306 4207120
SGTC_2143 5623677 140.463 µM 0.0603625109790821 0.466279137995608 no 1556 0.475933458045927 2296 5375313
SGTC_2395 5646831 180.19 µM 0.0601801749250479 0.46634827395406 no 1557 0.476006067605174 2262 6808628
SGTC_1871 st057448 67.3 µM 0.0581336702254072 0.467124311790548 no 1558 0.476821077386269 2288 691747
SGTC_2965 9082772 38.63 µM 0.0569473950377192 0.467574206639114 no 1559 0.477293549881761 2306 16459634
SGTC_949 1165-0505 146 µM 0.0566760139136764 0.467677133769487 no 1560 0.477401640709743 2239 6244267
SGTC_2982 9019404 25.97 µM 0.0564112239506154 0.467777563143245 no 1561 0.477507107887474 2252 22333232
SGTC_2244 6635614 200 µM 0.0552295196619239 0.468225784127735 no 1562 0.477977805765246 2175 836499
SGTC_1616 st002734 56.1 µM 0.0542474421393942 0.4685983172615 no 1563 0.478369011471595 2216 4026101
SGTC_2767 sibutramine 71.45 µM 0.0542245879254489 0.468606986917928 no 1564 0.478378115583891 2296 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_552 k242-0005 476 µM 0.0515852055091396 0.469608325373244 no 1565 0.479429603968782 2260 4088318
SGTC_2324 6149169 200 µM 0.0513411174380008 0.469700938197266 no 1566 0.479526852156135 2289 2888231
SGTC_2280 7785178 200 µM 0.05072782911777 0.469933641605913 no 1567 0.479771200381435 2284 2954328
SGTC_741 4582-0002 126 µM 0.0497956946747555 0.470287346216613 no 1568 0.480142598790306 2294 2912688
SGTC_2098 5376439 882.5 nM 0.0492867447596244 0.470480480557923 no 1569 0.480345391414854 2284 2844116
SGTC_3191 9110352 49.47 µM 0.0490701414385595 0.470562678455886 no 1570 0.480431699205876 2324 17122424
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0490196222239152 0.470581849964103 no 1571 0.480451829231617 2299 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1943 st076331 65.2 µM 0.0480965689817142 0.470932150876824 no 1572 0.480819640299467 2334 24208415
SGTC_567 1080-0542 68.4 µM 0.045087522062631 0.472074246140684 no 1573 0.482018773630156 2333 5950415
SGTC_817 1391-0715 46 µM 0.0445986782292267 0.472259810620027 no 1574 0.482213598116733 2288 1353946
SGTC_1775 st081588 35.1725 µM 0.0444199235046257 0.472327667185124 no 1575 0.482284840330954 2319 1426443 YGL099W LSG1
SGTC_1738 st035555 74 µM 0.0438044049263349 0.472561328548282 no 1576 0.482530157916526 2298 5331140
SGTC_554 4483-2211 187 µM 0.042157685883584 0.47318649742178 no 1577 0.483186497161652 2271 747107
SGTC_3141 9094609 49.47 µM 0.0401427195362936 0.473951559296679 no 1578 0.483989671983756 2282 25236309 YDL196W YDL196W
SGTC_793 0488-0545 106 µM 0.0399018603810299 0.474043017510304 no 1579 0.484085683958173 2286 292548
SGTC_1015 4130-4525 82 µM 0.0385694913857779 0.474548964687078 no 1580 0.484616813266451 2315 1363237
SGTC_3316 9136639 10.545 µM 0.0383894028692004 0.47461735377204 no 1581 0.484688605020281 2258 4903665
SGTC_2569 tetrandrine 100 µM 0.0377897080025043 0.474845094846412 no 1582 0.484927675168263 2276 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1122 capsaicin 818.572 nM 0.0365539341459026 0.475314420125605 no 1583 0.485420337093348 2298 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2949 9072542 2.23 µM 0.0358687686094487 0.475574648805416 no 1584 0.485693499437155 2301 16457352
SGTC_1000 4048-0884 8.67 µM 0.0350773030960526 0.475875263614497 no 1585 0.486009049888939 2302 13040088
SGTC_998 3996-0085 177 µM 0.0339690552248706 0.476296221888363 no 1586 0.486450913403352 2315 715391
SGTC_783 0848-0141 92.7 µM 0.0337475346202931 0.476380367742709 no 1587 0.486539236697594 2341 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2088 5278280 127.392 µM 0.0333317196638383 0.476538320246526 no 1588 0.486705029586368 2318 791502
SGTC_183 3914-0051 30.55 µM 0.031848003403953 0.477101958268365 no 1589 0.487296632426469 2331 1596232
SGTC_931 2812-0076 566 µM 0.0297557752902641 0.477896836952941 no 1590 0.48813091466998 2354 3450959
SGTC_2565 isoliquiritigenin 100 µM 0.0296594043696847 0.477933452307236 no 1591 0.488169344143253 2254 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1465 k213-0056 144 µM 0.029545114389255 0.477976876105261 no 1592 0.48821491927567 2303 24048857 YMR208W ERG12
SGTC_3202 9113761 49.47 µM 0.0294598316022114 0.478009278963123 no 1593 0.488248927381723 2331 4798415
SGTC_3117 9124945 49.47 µM 0.0293657398867901 0.478045028907164 no 1594 0.488286448311813 2339 17592065
SGTC_2928 9011484 9.79 µM 0.0287959695529606 0.478261515678372 no 1595 0.488513657689665 2322 2994751
SGTC_1721 st082152 9.2685 µM 0.0279832870950987 0.478570309074348 no 1596 0.488837740446761 2364 5296051
SGTC_2377 9073351 62.6 µM 0.0278481113068447 0.478621672812362 no 1597 0.488891646775618 2348 7337946 YHR072W ERG7
SGTC_2884 9058502 51.95 µM 0.0277911443274005 0.478643319080732 no 1598 0.48891436451961 2319 6471554
SGTC_2055 5235184 200 µM 0.0274801271823801 0.47876150024182 no 1599 0.489038395036333 2339 2836034
SGTC_1040 k898-0338 155 µM 0.0271714902111333 0.478878778823854 no 1600 0.489161477411597 2355 20969351
SGTC_2870 9038528 12.99 µM 0.0262265647489417 0.47923785121179 no 1601 0.489538313780685 2274 6463316
SGTC_875 0709-0210 25.7 µM 0.0257253274764349 0.479428328611679 no 1602 0.489738211067407 2356 6251364
SGTC_588 3970-1144 52.9 µM 0.0247966689873108 0.479781244627338 no 1603 0.490108574002981 2350 1888707
SGTC_1175 0741-0056 27.6 µM 0.0241873413225869 0.480012814690746 no 1604 0.490351587669483 2344 765927
SGTC_2385 9074692 200 µM 0.0241871084184812 0.480012903205367 no 1605 0.490351680557603 2348 17046906
SGTC_997 3996-0078 137 µM 0.0234486767406144 0.480293547244401 no 1606 0.49064618862052 2342 735687
SGTC_1285 0929-0069 65.5 µM 0.0229396583536584 0.480487007501347 no 1607 0.49084920295929 2346 1206237
SGTC_3039 9090270 49.47 µM 0.0227585774655178 0.48055583118516 no 1608 0.490921424926281 2370 17173750
SGTC_996 3970-0799 1.8 µM 0.021251528915945 0.481128639671085 no 1609 0.491522504708699 2322 6615648 YGL040C HEM2
SGTC_2416 tofa 880 nM 0.0210476968392859 0.481206116465682 no 1610 0.491603803757225 2321 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2315 7733312 200 µM 0.0194906829226872 0.481797962361869 no 1611 0.492224834791694 2358 726316
SGTC_970 1315-0089 19.5 µM 0.0192084665524945 0.481905241651563 no 1612 0.492337401758763 2376 6811083 YLR033W RSC58
SGTC_930 2810-3379 265 µM 0.0177070188990887 0.482476010815641 no 1613 0.492936290627377 2375 1015764
SGTC_1091 telmisartan 47.6 µM 0.0167541376821918 0.482838263405023 no 1614 0.493316378791707 2340 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_493 zm226600 134 µM 0.0154501728714529 0.483334008774499 no 1615 0.493836518014955 2372 5240098 A potassium channel opener. YCR052W RSC6
SGTC_814 3342-0569 96 µM 0.01417199468738 0.483819975516779 no 1616 0.494346381372794 2379 4346283
SGTC_654 1124-0271 80.9 µM 0.0122601051164866 0.48454692565619 no 1617 0.495109048233812 2373 5403748
SGTC_1581 himbacine 57.9 µM 0.0121614894281527 0.48458442331944 no 1618 0.495148387268479 2378 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2520 obtusaquinone 4.71 µM 0.0107901319629617 0.485105882735246 no 1619 0.495695443676751 2380 5967872
SGTC_1900 st060200 72.8 µM 0.00893618255652393 0.485810888325547 no 1620 0.496435026399921 2391 688945
SGTC_1603 st002045 67.8 µM 0.00848598337075075 0.485982093378435 no 1621 0.496614623073918 2391 5887985
SGTC_1007 4101-0031 70 µM 0.00725638496655842 0.48644970716336 no 1622 0.497105146638803 2393 1146276
SGTC_1674 st016616 23.6 µM 0.00696926163471304 0.486558902292405 no 1623 0.497219689377648 2388 625830
SGTC_4 0960-0234 25.671 µM 0.0066075098340562 0.486696480614394 no 1624 0.497364004139946 2329 6821112
SGTC_1048 3161-0300 24.5 µM 0.00617934628926526 0.486859318122347 no 1625 0.497534813188561 2390 2165101
SGTC_1936 st074407 74.3 µM 0.00331379858727447 0.487949187245699 no 1626 0.498677988054362 2399 809813
SGTC_2136 5328288 199.296 µM 0.00257789399512409 0.488229092635021 no 1627 0.49897157023003 2395 262395
SGTC_2933 9026794 32.47 µM 0.00257209857471284 0.488231296978478 no 1628 0.4989738822606 2396 17586027
SGTC_928 2764-0428 58.7 µM 0.00249291154492012 0.4882614165569 no 1629 0.49900547321353 2370 662578
SGTC_1836 st055642 81 µM 0.0023765105464316 0.488305690961834 no 1630 0.499051910355646 2399 8571
SGTC_1762 st045503 25.4615 µM 0.00108740766924869 0.488796024987212 no 1631 0.499566187190198 2402 4645554
SGTC_889 0919-1524 82.7 µM 0.000122817382502689 0.489162935788502 no 1632 0.499951002953475 2403 3905452
SGTC_1136 pergolide 1.05886 µM -0.0011835616501765 0.489659870737938 no 1633 0.499527827326521 2411 47811 A dopamine receptor agonist.
SGTC_2958 9077254 16.72 µM -0.00303555087588626 0.490364378268838 no 1634 0.498788992271119 2417 16457351
SGTC_1720 st037298 9.481 µM -0.00320346924397787 0.490428256917306 no 1635 0.498722002860459 2418 597396
SGTC_2837 9008476 45.46 µM -0.00359803582905214 0.49057835688685 no 1636 0.498564594478486 2418 2992805
SGTC_1587 estradiol valerate 56.1 µM -0.00421323358101676 0.490812391431383 no 1637 0.498319167960163 2418 13791 A steroid.
SGTC_2390 9097792 176.6 µM -0.00426741685920022 0.490833004076262 no 1638 0.498297552153938 2417 4497149
SGTC_529 4076-0302 30.3 µM -0.00463106488297924 0.490971345313718 no 1639 0.49815247901879 2417 5816522
SGTC_1734 st037168 69.4 µM -0.00472782227693355 0.491008154545475 no 1640 0.498113878826036 2422 708907
SGTC_2612 dictamnine 15.46 µM -0.00514296309202881 0.491166086643109 no 1641 0.497948263620811 2425 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2702 st077768 96.8 µM -0.00709223012427637 0.491907664773615 no 1642 0.497170633260506 2427 6484119
SGTC_3114 9122766 49.47 µM -0.00799825372970848 0.492252361597777 no 1643 0.496809192438301 2431 17176985
SGTC_1705 st027868 56.3335 µM -0.00804738813255638 0.492271054956824 no 1644 0.496789591278415 2439 292948
SGTC_627 1391-0720 175 µM -0.00839157082397667 0.492402000964618 no 1645 0.496652286889513 2430 997839
SGTC_425 3825-7017 13.1 µM -0.0102018658676312 0.493090749819543 no 1646 0.495930114964168 2482 3397440
SGTC_2671 danthron 100 µM -0.010873911977933 0.493346443320913 no 1647 0.495662022247307 2430 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1964 st076914 61 µM -0.0111377177933308 0.493446814318719 no 1648 0.495556785327794 2428 24208661
SGTC_2435 5706476 10.6 µM -0.0113177884844912 0.493515326598761 no 1649 0.495484952043609 2428 5725375
SGTC_3011 9081274 71.4286 µM -0.0115874043846853 0.493617908891432 no 1650 0.495377397915615 2439 6625322
SGTC_1930 st074634 34.3 µM -0.0128602660100751 0.494102207368474 no 1651 0.494869637567159 2423 684253 YOR116C RPO31
SGTC_3166 9102297 49.47 µM -0.0136244053058907 0.494392951360723 no 1652 0.494564816829129 2449 25237072
SGTC_2056 5235370 200 µM -0.0145711116876732 0.494753163612613 no 1653 0.494187173170009 2434 5511916
SGTC_1729 st035615 45.989 µM -0.0148666029295778 0.494865595946561 no 1654 0.494069301989332 2490 17385451
SGTC_959 1222-0044 107 µM -0.0155776842312028 0.495136159022281 no 1655 0.493785654463693 2435 6083612
SGTC_1386 3228-0095 33.8 µM -0.0156048198025681 0.495146484024092 no 1656 0.493774830252666 2441 870181
SGTC_1864 st057645 30.4 µM -0.0162195190835626 0.495380376075866 no 1657 0.493529631767347 2436 688666
SGTC_2272 7805186 180 µM -0.0182192221358895 0.496141270322296 no 1658 0.492731984067127 2431 2956062 YPR165W RHO1
SGTC_3333 9141820 12.094 µM -0.0203432599781424 0.4969494897178 no 1659 0.491884773222749 2459 1939433
SGTC_1626 st003712 1.76 µM -0.0211421594883577 0.497253483049841 no 1660 0.491566126996542 2462 24207035
SGTC_2406 ethylparaben 405.7 µM -0.0218138071769264 0.497509056382687 no 1661 0.491298240136808 2458 8434 A possible steroid mimic.
SGTC_973 1325-0077 65.9 µM -0.0219268741781662 0.497552080397031 no 1662 0.491253143715884 2470 2835149
SGTC_1127 asiatic acid 681.4 nM -0.0224099456787241 0.497735898049434 no 1663 0.491060473420335 2457 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1426 4048-4480 71.7 µM -0.0225633046830719 0.497794254093163 no 1664 0.490999307495659 2451 14224343
SGTC_2052 5265182 7.135 µM -0.0226678735824909 0.497834044592946 no 1665 0.490957601207499 2449 1239884
SGTC_1827 berberine 7.24 µM -0.022804601607222 0.497886072297754 no 1666 0.4909030687143 2450 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1058 3448-5425 97.3 µM -0.0228165547377898 0.497890620700946 no 1667 0.49089830134558 2448 7279705
SGTC_1236 0330-0013 258 µM -0.0230128506242487 0.497965315216761 no 1668 0.490820011174269 2464 4617066
SGTC_1919 st067113 52.3 µM -0.0233582062954601 0.498096730137272 no 1669 0.490682271223252 2469 1268243
SGTC_1480 1070-0044 41.2 µM -0.0233928042079003 0.498109895364613 no 1670 0.490668472423612 2521 3124987
SGTC_76 0433-0009 400.328 µM -0.023439679886241 0.498127732541256 no 1671 0.490649776859883 2522 2841569
SGTC_3225 9130819 49.47 µM -0.0241002061574338 0.498379076992632 no 1672 0.490386339440703 2453 4547121
SGTC_1814 st052110 31.539 µM -0.0254702469085342 0.498900408899735 no 1673 0.48983994015629 2452 674163
SGTC_1375 2910-0797 186 µM -0.025564596249744 0.498936311065831 no 1674 0.489802312467386 2467 742508
SGTC_2242 6630449 61.2675 µM -0.0259424970908074 0.499080111398313 no 1675 0.489651601832321 2583 691249 YDR170C SEC7
SGTC_925 2064-1272 59.6 µM -0.0264017414993557 0.499254865068 no 1676 0.489468452559843 2478 6815817
SGTC_756 0508-1999 28.3 µM -0.0266272326472909 0.499340669989828 no 1677 0.48937852622274 2455 6753853
SGTC_2434 5670830 169.91 µM -0.0283599178448628 0.5 no 1678 0.488687546129343 2485 1549830
SGTC_1230 0170-0365 3.77 µM -0.0298300067187884 0.49944059438081 no 1679 0.488101313754658 2493 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3165 9101544 49.47 µM -0.0301813346346945 0.499306905435088 no 1680 0.487961217276886 2468 5002184
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.0304733744038415 0.499195777151534 no 1681 0.487844763832081 2454 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2814 7977482 42.97 µM -0.0319184005675021 0.498645910396127 no 1682 0.487268562292329 2487 6456762
SGTC_1259 0671-0132 43 µM -0.0328184179778939 0.498303433641732 no 1683 0.486909695350527 2488 X1259
SGTC_2185 6113692 200 µM -0.0328431761584423 0.498294012616807 no 1684 0.48689982358715 2510 874150
SGTC_1116 jasmonic acid 1.58368 µM -0.032886651289221 0.498277469388487 no 1685 0.486882488883495 2487 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_833 3852-0053 558 µM -0.0331700142160579 0.498169643735028 no 1686 0.486769505073836 2492 3123681
SGTC_2831 7999036 19.48 µM -0.0336623326608853 0.497982306360968 no 1687 0.486573208059967 2504 2988270
SGTC_1373 2887-0003 58.5 µM -0.0342681434624315 0.49775178340743 no 1688 0.486331663888383 2504 776948
SGTC_837 0091-0265 12.5 µM -0.0350711169072669 0.49744623735083 no 1689 0.486011516303642 2470 759367
SGTC_2664 lyso-paf C-16 73.48 µM -0.0351770770447858 0.497405917691874 no 1690 0.485969270392244 2469 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3143 9086658 49.47 µM -0.0356348127815529 0.497231741662915 no 1691 0.485786774677619 2528 25236626
SGTC_2419 paclitaxel 166.5 µM -0.0370879234337365 0.496678812649042 no 1692 0.485207450554344 2452 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1345 1488-0192 31.4 µM -0.0371873130028301 0.496640993743018 no 1693 0.485167827186769 2477 658348
SGTC_3335 9143315 29.6265 µM -0.0373278530832624 0.496587516632552 no 1694 0.485111798707474 2492 4899691
SGTC_1852 st056254 31.4 µM -0.0377264143784476 0.49643585983102 no 1695 0.484952907677931 2525 442583
SGTC_49 0717-0965 32.132 µM -0.0382572896329251 0.496233856967866 no 1696 0.484741271886433 2689 5889349 YGL099W LSG1
SGTC_1033 k072-0102 21.3 µM -0.0382824228924919 0.496224293557522 no 1697 0.484731252506336 2468 5965931
SGTC_2404 5161160 200 µM -0.0390888478571537 0.495917443460295 no 1698 0.484409776147976 2480 2831543
SGTC_1880 MG-132 525 µM -0.0392838694607261 0.495843236790478 no 1699 0.484332033497431 2502 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2082 5219693 150 µM -0.0396868084444344 0.49568991700354 no 1700 0.484171409364211 2467 2834649
SGTC_2077 5212015 200 µM -0.0404731674842435 0.495390706308709 no 1701 0.483857949376778 2456 780900
SGTC_200 k038-0079 37.545 µM -0.04053578782653 0.495366879291698 no 1702 0.483832987959041 2509 3436683
SGTC_994 3910-0338 138 µM -0.0406918528055133 0.495307496697197 no 1703 0.483770778368473 2526 3479481
SGTC_1196 1588-0294 184 µM -0.0409456485411924 0.495210927853804 no 1704 0.483669612833822 2530 6144269
SGTC_87 0100-0052 35.5 µM -0.04107820862502 0.49516048907982 no 1705 0.483616773467753 2490 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3218 9131285 49.47 µM -0.0414563308656144 0.495016614958978 no 1706 0.483466052911987 2499 17156417
SGTC_1710 st031758 61.5 µM -0.041684878977573 0.494929653556671 no 1707 0.483374954155808 2582 5394341
SGTC_1952 st077036 64.1 µM -0.0417173626375317 0.494917293707578 no 1708 0.483362006313366 2475 2937007
SGTC_1478 0453-0656 35.7 µM -0.0424290229632158 0.494646512219409 no 1709 0.483078346098353 2490 5258496
SGTC_383 2324-0395 7.37 µM -0.0428425275293752 0.494489177916593 no 1710 0.482913531513789 2536 3146421
SGTC_1148 3909-7663 27.7 µM -0.0429423077543818 0.494451212678196 no 1711 0.482873761563705 2587 4084526
SGTC_503 tyrphostin 8 294 µM -0.043297395504129 0.49431610624648 no 1712 0.482732233681923 2479 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_618 k072-0232 33.2 µM -0.0436259861714956 0.494191082202494 no 1713 0.482601268721856 2508 5872756 YGL099W LSG1
SGTC_1796 st049173 110.4 µM -0.0437013955805848 0.494162390082144 no 1714 0.482571213384417 2478 94134
SGTC_2686 alizarin 95.37 µM -0.0438007601213485 0.494124583448763 no 1715 0.482531610589074 2520 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2690 usnic acid 100 µM -0.0440313655856108 0.494036841927371 no 1716 0.482439700991609 2521 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_851 0394-0702 453 µM -0.0445485650546855 0.493840057237002 no 1717 0.482233570530329 2479 762646
SGTC_1863 st057641 20.1 µM -0.04502931550415 0.493657142057726 no 1718 0.482041971126884 2474 3921635
SGTC_2350 9023895 38.85 µM -0.0451146214655532 0.493624685117137 no 1719 0.482007973522431 2535 2997209
SGTC_2688 kanamycin b 96.69 µM -0.0457202192119076 0.493394270440668 no 1720 0.481766624029464 2505 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_364 0083-0097 67.7 µM -0.0467039467959545 0.493019991624721 no 1721 0.481374592346075 2545 5207356
SGTC_823 0417-1665 178 µM -0.046832816606834 0.492970960978274 no 1722 0.481323236924989 2544 3429856
SGTC_2804 7954240 19.48 µM -0.0469360777612209 0.492931673644443 no 1723 0.481282086936414 2535 828705
SGTC_3133 9127736 49.47 µM -0.0472597672797947 0.49280852131105 no 1724 0.481153096645715 2474 27243420
SGTC_2798 7813637 45.45 µM -0.0473927551197168 0.492757924372404 no 1725 0.481100101555413 2536 956368
SGTC_193 1273-0060 1.558 µM -0.0474795125710102 0.492724916444026 no 1726 0.481065529258915 2484 2847393 YHR072W ERG7
SGTC_495 decylubiquinone 155 µM -0.0485405672001694 0.492321229393463 no 1727 0.480642717289409 2542 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1055 3448-0672 86 µM -0.050523667367826 0.4915667638616 no 1728 0.479852544827027 2576 748378
SGTC_2340 7987427 183.45 µM -0.0526820401346023 0.490745650682007 no 1729 0.478992624524046 2544 2239331
SGTC_2468 5987765 72.9 µM -0.0532263571407425 0.490538581353999 no 1730 0.478775777707459 2562 26772094
SGTC_1322 1348-1070 12 µM -0.0537019650305351 0.490357652465402 no 1731 0.478586308597529 2490 6758089
SGTC_591 4299-0174 154 µM -0.0539558947176031 0.490261054339538 no 1732 0.478485151968974 2543 5509088
SGTC_3037 9091026 49.47 µM -0.05458246637966 0.490022700858927 no 1733 0.478235553867281 2519 25236398 YIL048W NEO1
SGTC_2985 9022375 71.43 µM -0.0557749047729894 0.489569096511258 no 1734 0.477760563452839 2671 4939335
SGTC_3048 9093155 49.47 µM -0.0577375302730663 0.48882254213292 no 1735 0.4769788493554 2507 25236002
SGTC_3312 9133330 71.43 µM -0.0591654981507149 0.488279388250229 no 1736 0.476410144984323 2633 17617324
SGTC_2795 7780010 54.55 µM -0.059414793292154 0.488184566451971 no 1737 0.476310865265865 2579 953673
SGTC_2683 piperine 63.03 µM -0.0595119768595131 0.488147601930585 no 1738 0.476272163115774 2521 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_458 nppb 133 µM -0.0608649754558444 0.487632989169283 no 1739 0.475733371623008 2546 4549 A chloride channel blocker.
SGTC_946 3434-1334 87.4 µM -0.0618357396502275 0.487263771827763 no 1740 0.475346820904292 2589 4047976
SGTC_735 3076-0345 636 µM -0.0619180893616677 0.487232451700361 no 1741 0.475314030955053 2549 2888990
SGTC_1521 st012942 49.4 µM -0.0619686071261461 0.487213238280137 no 1742 0.47529391591043 2711 24207259
SGTC_941 3237-0776 460 µM -0.0624996102333561 0.487011283684416 no 1743 0.475082486161745 2561 760008
SGTC_1969 st069479 40.1 µM -0.0634534134265208 0.486648535377331 no 1744 0.474702727571423 2552 3895485
SGTC_2629 bisabolol 100 µM -0.0637436615882643 0.486538151021055 no 1745 0.474587169248427 2559 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3008 9078912 71.4286 µM -0.0640265214287031 0.486430577511516 no 1746 0.474474554541141 2549 16648731
SGTC_42 0133-0086 60.653 µM -0.0651067604488704 0.486019764462709 no 1747 0.474044498897807 2532 162923 Model of phenazepam hydroxylation.
SGTC_2853 9015042 58.44 µM -0.0696461592194134 0.484293606134386 no 1748 0.472237648184694 2532 6457456
SGTC_3337 9144342 33.5465 µM -0.0703511103461864 0.484025565986213 no 1749 0.471957101535495 2612 17682949
SGTC_3052 9092717 49.47 µM -0.0704719474866075 0.483979621387707 no 1750 0.471909013843218 2621 25237534
SGTC_2141 5621638 7.665 µM -0.0706456275906961 0.483913585253593 no 1751 0.471839897769491 2623 2856238
SGTC_1853 st056710 91.2 µM -0.0711218145085104 0.483732533144561 no 1752 0.471650403332456 2669 269167
SGTC_1502 4534-4282 27.7 µM -0.0730209889665225 0.483010477446883 no 1753 0.470894707657511 2559 3278949
SGTC_3081 9117243 49.47 µM -0.0739607569277137 0.482653203289314 no 1754 0.470520805567776 2682 45595589
SGTC_2037 5169046 200 µM -0.074155806013433 0.482579052680689 no 1755 0.470443205337147 2612 5718022
SGTC_633 0437-0093 97.7 µM -0.0744114230876619 0.482481877225959 no 1756 0.470341509847015 2524 2831118
SGTC_1244 0416-0015 52.5 µM -0.0759436150138421 0.481899420753331 no 1757 0.469731978632768 2572 96201
SGTC_467 ro 31-8220 72.8 µM -0.0764997429834604 0.481688020478961 no 1758 0.469510759223583 2593 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2749 bexarotene 57.39 µM -0.0778651072679699 0.481169028112254 no 1759 0.46896767773848 2588 82146 An retinoic acid receptor inhibitor.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.078457010942878 0.480944047846533 no 1760 0.46873226253298 2801 5282309
SGTC_2777 climbazole 1.536 µM -0.0796600325257419 0.480486802840419 no 1761 0.468253823907326 2550 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_265 mycophenolic acid 32.932 µM -0.0801629050693185 0.48029567838289 no 1762 0.468053846323298 2730 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1228 0124-0032 52.5 µM -0.0807262802077318 0.480081564364147 no 1763 0.46782981821799 2587 X1228
SGTC_2073 5212005 126 µM -0.0818492571940798 0.479654787593401 no 1764 0.467383292934155 2531 691789
SGTC_454 lyso-paf C-16 6.67 µM -0.0821925846898575 0.479524313862031 no 1765 0.467246785027658 2602 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2129 girgensonine 121.053 µM -0.0822116140350756 0.47951708226037 no 1766 0.46723921902296 2610 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2444 5485484 36.41 µM -0.0823922086967777 0.479448452349689 no 1767 0.467167415772576 2631 6790631
SGTC_2806 7952793 58.44 µM -0.0834664980412662 0.479040211627198 no 1768 0.466740307551067 2649 2972490
SGTC_3083 9117465 49.47 µM -0.0837614263090057 0.478928139756949 no 1769 0.46662305877338 2647 16420915
SGTC_1393 3470-5649 58.2 µM -0.0844818937504379 0.478654371281936 no 1770 0.466336649033049 2648 4108395
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0859088764239029 0.478112165845707 no 1771 0.465769427617441 2661 688751
SGTC_2754 granisetron 64.02 µM -0.0866646926434833 0.477824997441769 no 1772 0.465469020987684 2621 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_113 0099-0221 2.5 µM -0.0869418606675786 0.477719691783673 no 1773 0.465358862737864 2548 89219
SGTC_2482 5981709 142.65 µM -0.0872385917051041 0.477606955188808 no 1774 0.465240932264699 2626 877755
SGTC_1961 st076550 68.7 µM -0.0873060175520763 0.477581338433604 no 1775 0.465214135486344 2652 1579337
SGTC_440 fluspirilene 35.1 µM -0.0880466983523984 0.477299941508047 no 1776 0.464919780158425 2812 3396 An atypical antipsychotic.
SGTC_2070 5230947 200 µM -0.0893652257381341 0.476799039173849 no 1777 0.464395829353059 2557 2835538
SGTC_2907 7721985 69.9 µM -0.0894424124282729 0.476769717442406 no 1778 0.464365159138318 2607 3267881
SGTC_667 1498-1044 59 µM -0.0894691953149801 0.476759543170886 no 1779 0.464354516978814 2610 6739982
SGTC_2215 7188065 200 µM -0.0895969314499498 0.476711019031245 no 1780 0.464303761474468 2647 940217
SGTC_1757 st041620 31.8375 µM -0.0897482234451616 0.476653546986752 no 1781 0.464243646883338 2621 5289815
SGTC_2439 5492030 7.2 µM -0.0898110525439665 0.476629679926396 no 1782 0.464218682513599 2621 5722370
SGTC_1941 st076221 61.8 µM -0.0911245626187224 0.476130732615065 no 1783 0.463696807843923 2718 2828568
SGTC_399 oxolinic acid 75 µM -0.0919316491209407 0.475824172861504 no 1784 0.463376172782789 2572 4628 A DNA gyrase inhibitor.
SGTC_31 0508-1974 57.237 µM -0.0924844285714726 0.475614216089168 no 1785 0.463156581197335 2574 6810525
SGTC_1678 st019265 80.2 µM -0.0927056450618432 0.475530195502951 no 1786 0.463068706108521 2589 5367020
SGTC_2300 7976697 71.57 µM -0.0929173130254133 0.475449802576457 no 1787 0.462984625722562 2601 2236109
SGTC_2321 7390090 138.78 µM -0.0945339854187559 0.474835812656374 no 1788 0.462342493428666 2646 649046
SGTC_571 k831-0106 44.2 µM -0.0946646817693253 0.474786178572895 no 1789 0.462290585910043 2587 4783639
SGTC_315 k915-0449 187 µM -0.0949092264485347 0.474693309770391 no 1790 0.462193463978991 2600 20970215 YNL149C PGA2
SGTC_799 1310-0557 151 µM -0.0951569126513364 0.474599249337942 no 1791 0.462095096676625 2705 5354492
SGTC_1806 st050005 60.3 µM -0.0957915531217508 0.474358247001427 no 1792 0.461843063070611 2580 5194765
SGTC_779 1360-0071 233 µM -0.0962586774357551 0.474180864286558 no 1793 0.461657564631844 2747 7566
SGTC_1444 4112-3581 28 µM -0.097078756413211 0.473869465291372 no 1794 0.461331925546402 2566 2877249
SGTC_2172 5754775 163.918 µM -0.0983083185485432 0.473402608020524 no 1795 0.460843736467184 2605 2263357
SGTC_501 nsc-95397 161 µM -0.0983924777486137 0.473370654612148 no 1796 0.460810323792479 2739 262093
SGTC_1556 plumbagin 1.48 µM -0.0989290563249658 0.473166931494811 no 1797 0.460597299226172 2579 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_555 4296-0685 37 µM -0.0997884351198336 0.472840665263985 no 1798 0.460256144828863 2563 2908540 YHR072W ERG7
SGTC_201 4262-0159 12.803 µM -0.101095930478302 0.472344305000211 no 1799 0.45973715425222 2667 1341029
SGTC_802 4112-3352 742 µM -0.101929998906195 0.472027692668746 no 1800 0.459406119141666 2737 704594
SGTC_3017 9080681 49.47 µM -0.102538235204214 0.471796817335101 no 1801 0.459164732734504 2652 16451914
SGTC_3320 9137005 35.139 µM -0.105039311103345 0.470847555282622 no 1802 0.458172307745202 2656 4908713
SGTC_1694 st024011 44.9 µM -0.106487391745457 0.470298023968593 no 1803 0.457597829229192 2609 2787533
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.108047653886255 0.469705984293166 no 1804 0.456978945554224 2718 5282362
SGTC_488 nitrendipine 139 µM -0.109782998116701 0.469047588638069 no 1805 0.456290737535448 2598 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1596 piperlongumine 63 µM -0.111664446314 0.468333856306086 no 1806 0.455544735352224 2730 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1892 st058411 7.36 µM -0.111751291624181 0.468300913748426 no 1807 0.455510304582454 2713 3934738
SGTC_1433 4060-0023 7.6 µM -0.111942448849136 0.468228403886295 no 1808 0.455434519394737 2704 3840627
SGTC_302 1094-0063 18.9 µM -0.1124792457858 0.468024791424907 no 1809 0.455221712385134 2606 5440289
SGTC_294 k038-0071 157 µM -0.112727210336163 0.467930738805403 no 1810 0.4551234140083 2654 24152826
SGTC_597 k018-0003 82.8 µM -0.113161864492833 0.46776587939226 no 1811 0.454951114567592 2710 6786234
SGTC_577 r071-0003 38.6 µM -0.114038804632972 0.467433282758173 no 1812 0.454603516215715 2601 4568517 YMR134W ERG29
SGTC_2160 5660466 132.927 µM -0.115605233085787 0.46683924097333 no 1813 0.453982707657863 2583 2859134
SGTC_1760 st045453 10.4495 µM -0.117980649670396 0.46593854532768 no 1814 0.453041495057374 2633 3323419 YIL048W NEO1
SGTC_1056 3448-1962 115 µM -0.118345230117772 0.465800321313426 no 1815 0.452897060364298 2710 715507
SGTC_1619 st003326 88.7 µM -0.118425815881522 0.465769769249889 no 1816 0.452865135795153 2749 2849032
SGTC_1400 3771-8998 51.5 µM -0.120081358208298 0.465142156959838 no 1817 0.45220934976038 2657 670767
SGTC_2107 5363541 170.161 µM -0.120252202242428 0.465077395287997 no 1818 0.452141683174448 2621 244052
SGTC_196 k015-0023 18.111 µM -0.120893390482514 0.464834348987293 no 1819 0.45188773870208 2627 5211998
SGTC_621 3584-0052 32.1 µM -0.121690247898485 0.464532313632754 no 1820 0.451572168442531 2625 2273927
SGTC_3232 9132874 49.47 µM -0.12211481139538 0.464371398338516 no 1821 0.451404045935693 2628 3784940
SGTC_1260 0700-1617 7.75 µM -0.123665638405768 0.463783663691138 no 1822 0.450790009672412 2697 2853078
SGTC_225 nsc-122657 1.016 µM -0.123695876436607 0.463772204820113 no 1823 0.450778038356672 2740 275685
SGTC_2236 dapsone 200 µM -0.125253890462923 0.463181827568126 no 1824 0.450161277352109 2643 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2791 5663188 71.43 µM -0.126455641373294 0.462726504191619 no 1825 0.449685630077015 2746 54690634
SGTC_132 0417-1715 25.805 µM -0.126666073944714 0.462646779807275 no 1826 0.449602349286572 2667 6769098
SGTC_3075 9116269 49.47 µM -0.126762225318639 0.462610352442529 no 1827 0.449564297159306 2773 17015205 YNL244C SUI1
SGTC_1246 0422-0085 105 µM -0.128312616137427 0.462023023664439 no 1828 0.448950790701227 2675 264295
SGTC_1170 0310-0127 64.8 µM -0.129747210553199 0.461479635333166 no 1829 0.448383214807216 2712 774975
SGTC_2155 5570423 76 µM -0.130646371075613 0.461139092504012 no 1830 0.448027529131777 2647 797402
SGTC_2202 7226349 200 µM -0.131224789584467 0.460920040685565 no 1831 0.447798743133699 2630 844334
SGTC_1515 3460-0031 42.1 µM -0.13160753088663 0.460775099940002 no 1832 0.447647364278881 2661 2876596
SGTC_2306 7482397 179.52 µM -0.13211529861104 0.460582820839726 no 1833 0.447446547720297 2748 891448
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.133617684034503 0.460013958720243 no 1834 0.446852449875078 2645 16623 A steroid.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.134326846622918 0.459745470276992 no 1835 0.446572062540988 2643 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1657 st012939 43.4 µM -0.134514068843724 0.459674591137274 no 1836 0.446498043431698 2746 24207257
SGTC_1034 k072-0165 12.7 µM -0.134586133399621 0.459647309066948 no 1837 0.446469552896645 2765 5835461
SGTC_1631 benzylvanillin 81.9 µM -0.134603272109491 0.459640820752866 no 1838 0.446462777192868 2770 75506
SGTC_2954 9074818 52.69 µM -0.134768429240328 0.459578296683065 no 1839 0.446397483943294 2750 16648742
SGTC_2161 5662504 8.5105 µM -0.135218564111948 0.459407892746976 no 1840 0.446219534926101 2674 2859334
SGTC_561 1550-0330 72.9 µM -0.135804737443044 0.459186001008806 no 1841 0.445987822912087 2667 6812934
SGTC_2112 5488546 200 µM -0.137826601885405 0.458420736619002 no 1842 0.445188729866217 2652 600757
SGTC_2742 clothiapine 36.27 µM -0.139373520134191 0.457835340600162 no 1843 0.444577497993217 2647 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3231 9132313 49.47 µM -0.140168903265593 0.457534381470481 no 1844 0.444263270454211 2700 4905967
SGTC_107 0358-0022 2.6945 µM -0.140719273037801 0.457326145373732 no 1845 0.444045859459097 2728 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2308 7584454 197.62 µM -0.141782740329117 0.456923808626621 no 1846 0.443625808777008 2752 893577
SGTC_2564 betulinic acid 100 µM -0.142574869276587 0.45662415474986 no 1847 0.443312973047808 2842 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3009 9080819 71.4286 µM -0.142588369686158 0.456619047903137 no 1848 0.443307641632542 2725 17027216
SGTC_1809 st050081 57.6 µM -0.143083271496481 0.45643184463243 no 1849 0.443112208204309 2804 5036894
SGTC_404 fumagillin 50 µM -0.143229060576976 0.456376699792537 no 1850 0.443054639704198 2698 12015870 A methionine aminopeptidase binder.
SGTC_816 0325-0417 81.3 µM -0.144097142521112 0.456048364513126 no 1851 0.442711880556038 2725 68101
SGTC_601 0986-0029 62.9 µM -0.144630300826571 0.455846722512831 no 1852 0.442501386081918 2673 24747981
SGTC_1043 0916-0009 19.3 µM -0.145015849667998 0.455700913917479 no 1853 0.442349178923019 2660 3101130
SGTC_2438 5259590 200 µM -0.145201312043172 0.455630777046173 no 1854 0.442275965026398 2783 1201127
SGTC_2191 5911152 200 µM -0.14552036811537 0.455510121876295 no 1855 0.442150017742457 2687 2875902
SGTC_2476 5806916 10.51 µM -0.147633618518025 0.454711073090305 no 1856 0.441315961035851 2685 2870194
SGTC_2210 7115885 190.385 µM -0.148303240022603 0.454457918144413 no 1857 0.441051729234133 2669 2927039
SGTC_1088 bifonazole 369 nM -0.148492705075612 0.45438629295062 no 1858 0.440976971320334 2629 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1267 0828-0272 9.49 µM -0.148704779169511 0.454306122415227 no 1859 0.440893294969983 2777 745334
SGTC_2594 a-mangostin 100 µM -0.148734408109311 0.454294921912099 no 1860 0.440881604730194 2813 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_321 4534-3890 65.3 µM -0.149498192402246 0.454006204327076 no 1861 0.440580267797106 2784 699746
SGTC_2663 amphotericin b 100 µM -0.150999617178347 0.453438722745303 no 1862 0.439988008941567 2674 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_699 0375-0592 111 µM -0.151523294946033 0.453240814725599 no 1863 0.439781468137848 2687 762578
SGTC_914 3820-6779 408 µM -0.152852159657776 0.452738663125507 no 1864 0.439257431763163 2662 2893481
SGTC_3270 9137563 49.47 µM -0.154226267760971 0.452219494432488 no 1865 0.438715665644832 2797 17015724
SGTC_845 0330-0138 4.51 µM -0.155356072502991 0.451792690152942 no 1866 0.438270306348529 2741 9039800
SGTC_318 1488-0629 67.2 µM -0.156732560365455 0.451272772173303 no 1867 0.437727812371941 2764 3662576
SGTC_2780 5215298 71.43 µM -0.157598119263784 0.450945881680957 no 1868 0.437386742831348 2762 2834131
SGTC_406 estrone 100 µM -0.15775520615271 0.450886559168068 no 1869 0.43732484843886 2835 5870 A steroid.
SGTC_1475 4092-1048 11.7 µM -0.159861173920925 0.450091365011651 no 1870 0.436495216915976 2743 2881759
SGTC_668 1682-0499 62.6 µM -0.161902712998376 0.449320689739353 no 1871 0.43569123317213 2730 682214
SGTC_89 0302-0250 142.109 µM -0.16209374738871 0.449248584528133 no 1872 0.435616014972505 2649 4203518 YLR208W SEC13
SGTC_2084 5306078 60.6385 µM -0.163328365081223 0.448782623248974 no 1873 0.435129950827171 2766 679340
SGTC_1093 fluphenazine 7.97 µM -0.164573471487855 0.448312774929261 no 1874 0.434639856574717 2710 6602611 An atypical antipsychotic.
SGTC_3174 9107204 49.47 µM -0.165782310304006 0.447856681751423 no 1875 0.434164133903236 2813 3938802
SGTC_287 k060-0039 29.6 µM -0.166157064360211 0.44771530154393 no 1876 0.434016673681947 2826 5861974
SGTC_1211 1056-0033 32.3 µM -0.170389718365523 0.446118950329031 no 1877 0.432351828733446 2712 6741922
SGTC_898 1000-0849 28.3 µM -0.171153943449153 0.445830814083777 no 1878 0.432051360423125 2688 6751807
SGTC_2544 sphondin 68.51 µM -0.172565269209239 0.445298776383903 no 1879 0.431496576715887 2938 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1262 0737-0114 49.6 µM -0.174003275548371 0.444756782034614 no 1880 0.4309314439936 2770 765919
SGTC_516 3992-2719 87.3 µM -0.174037883547893 0.444743739313216 no 1881 0.430917844878274 2670 5350887 YDR037W KRS1
SGTC_142 0335-0849 62.6745 µM -0.17463335543664 0.44451933312523 no 1882 0.430683868729954 2730 3889043 YPR107C YTH1
SGTC_2409 alverine citrate 63.97 µM -0.174732319200688 0.444482039918861 no 1883 0.430644985689287 2989 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2278 7948257 134.34 µM -0.175306000237759 0.444265865379729 no 1884 0.430419598636773 2839 1247028
SGTC_2222 6885208 172.143 µM -0.176855930850861 0.443681903473711 no 1885 0.429810777478649 2749 609514
SGTC_334 1502-1024 68.5 µM -0.176940625944515 0.44364999671297 no 1886 0.429777513581476 2826 3296216
SGTC_1445 4239-0156 97.7 µM -0.179366511359268 0.442736260858982 no 1887 0.428824962496028 2898 4008346
SGTC_1835 st008666 49.2 µM -0.180823934167 0.44218745297649 no 1888 0.428252888016855 2741 690455
SGTC_1555 citronellol 128 µM -0.180939448010667 0.442143959755271 no 1889 0.428207552409659 2741 8842 A terpine precursor.
SGTC_747 3448-8087 38.7 µM -0.180969031495716 0.44213282110675 no 1890 0.428195941960103 2780 5168703
SGTC_1798 st045719 60.953 µM -0.181908846456433 0.441778989817197 no 1891 0.427827130932516 2721 3980186
SGTC_2815 7968870 71.43 µM -0.18307797314341 0.44133888973659 no 1892 0.427368419274269 2755 2977326 YHR190W ERG9
SGTC_3295 9122362 53.5725 µM -0.183441305956629 0.441202133312925 no 1893 0.427225884119591 2812 4730473
SGTC_1716 st033144 30.6155 µM -0.183928325438349 0.441018832923494 no 1894 0.427034841693922 2844 674617
SGTC_979 1426-2828 121 µM -0.186568783695223 0.440025259885243 no 1895 0.425999371976501 2876 747872
SGTC_1529 apigenin 74 µM -0.186801835568252 0.439937583279509 no 1896 0.425908003838146 2964 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_855 0428-0020 25 µM -0.187501419304277 0.439674410108507 no 1897 0.425633755489818 2755 6812414
SGTC_2281 7943571 200 µM -0.189391286431897 0.438963603322302 no 1898 0.424893076653518 2872 1244024
SGTC_2429 5902844 64.44 µM -0.190060159132958 0.43871207750558 no 1899 0.424630994692414 2900 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1201 1889-3372 45.9 µM -0.190177634474971 0.438667904116289 no 1900 0.424584968192066 2782 5392199
SGTC_912 3474-0017 2.18 µM -0.190266844232156 0.438634359737408 no 1901 0.424550016753259 2898 3360550
SGTC_1379 2144-0755 36.5 µM -0.191146290549245 0.438303696664062 no 1902 0.424205490786561 2850 5392327
SGTC_12 0849-0099 9.267 µM -0.191753425825381 0.438075444949557 no 1903 0.42396767733382 2725 6071388
SGTC_2296 7971656 126.45 µM -0.19235578202021 0.437849010281367 no 1904 0.423731763194382 2818 666570
SGTC_3016 9080866 49.47 µM -0.192360835779159 0.437847110584063 no 1905 0.423729783993991 2771 17066299
SGTC_339 3091-4833 71.4 µM -0.19474201794515 0.436952189337635 no 1906 0.422797458017497 2759 3240077
SGTC_92 0063-0024 660.874 µM -0.195199157614235 0.436780419000803 no 1907 0.42261851925127 2684 3594437
SGTC_886 0866-0150 153 µM -0.195281880914576 0.436749336974092 no 1908 0.422586140468871 2947 271463
SGTC_1227 3909-8010 46.6 µM -0.195936083960479 0.436503543861651 no 1909 0.422330096858328 2767 15982272
SGTC_2413 inermin 26.06 µM -0.195939383477335 0.436502304249688 no 1910 0.422328805568327 3060 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1208 2323-2347 50.3 µM -0.19641250690921 0.436324560606598 no 1911 0.422143653909465 2892 5412760
SGTC_400 oxethazaine 37.5 µM -0.198684315211139 0.43547126433944 no 1912 0.421254847033157 2830 4621 A local anesthetic.
SGTC_2916 7875993 68.79 µM -0.200491725419326 0.434792611368099 no 1913 0.420548014390839 2762 1299250
SGTC_805 3852-0218 479 µM -0.201913767231996 0.434258792832761 no 1914 0.419992069524851 2758 6615355
SGTC_41 0478-0632 82.643 µM -0.202864662781062 0.433901904123296 no 1915 0.419620407480932 2775 3750424
SGTC_566 0958-0068 16.5 µM -0.202894963807896 0.433890532470993 no 1916 0.419608565357488 2927 6815365
SGTC_1306 1185-0270 9.02 µM -0.202912361936246 0.433884003163649 no 1917 0.419601765924987 2874 1548076
SGTC_3224 9130643 49.47 µM -0.205441210105073 0.432935149776936 no 1918 0.41861371292474 2971 17644395
SGTC_377 3970-0964 33.1 µM -0.205453631758875 0.432930489976782 no 1919 0.41860886088894 2759 16481235
SGTC_2396 5342950 42.78 µM -0.205880785927492 0.432770255071456 no 1920 0.418442017270395 2857 1886677
SGTC_913 3487-1245 167 µM -0.207070152950774 0.432324155713505 no 1921 0.417977535699646 2736 4016153
SGTC_2167 5876490 200 µM -0.207370611053435 0.432211475642432 no 1922 0.417860216357274 3005 686534
SGTC_53 0973-0023 39.979 µM -0.20737477166457 0.432209915337247 no 1923 0.417858591822111 2752 674768
SGTC_91 0417-1751 58.384 µM -0.207770192046866 0.432061630298691 no 1924 0.417704204001735 2740 6795624
SGTC_538 2922-0838 53.3 µM -0.209587951557032 0.431380082910975 no 1925 0.416994642028205 2903 777039
SGTC_1767 st044992 70.3 µM -0.211769714101428 0.430562326756194 no 1926 0.416143348638701 2838 9600693
SGTC_16 erodoxin 22.806 µM -0.212208516178945 0.430397893234478 no 1927 0.415972181546018 2826 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3103 9120822 49.47 µM -0.212437198174578 0.430312203376704 no 1928 0.415882984016788 3008 17141819
SGTC_3233 9132340 49.47 µM -0.212537341856572 0.430274679383544 no 1929 0.41584392428647 2803 17682950
SGTC_1832 st054113 55 µM -0.213310115162048 0.429985141227668 no 1930 0.415542542177204 2825 1251267
SGTC_2900 5328528 85.29 µM -0.213460714979659 0.429928719752495 no 1931 0.415483813925397 2783 795359
SGTC_910 3454-3003 490 µM -0.213668329918801 0.429850940190959 no 1932 0.415402855021037 2861 820824
SGTC_293 4049-0273 38.5 µM -0.214230853405376 0.429640213601791 no 1933 0.415183518510683 2811 1380311
SGTC_3322 9139058 2.11 µM -0.214905985322649 0.429387329305624 no 1934 0.414920309153571 2965 4908926 YPR165W RHO1
SGTC_3180 9109287 49.47 µM -0.215217765487342 0.429270555521324 no 1935 0.414798770299661 2909 18891271
SGTC_2436 5633522 8.09 µM -0.216925309500331 0.428631123987084 no 1936 0.414133276538113 2914 5724242
SGTC_289 k017-0060 526 µM -0.217697862639991 0.428341884045357 no 1937 0.41383226455469 2800 5512909
SGTC_1101 ebselen 5.29 µM -0.218118579267238 0.428184386071196 no 1938 0.413668360868494 2941 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_296 1222-0039 74.9 µM -0.218993934575362 0.427856727873072 no 1939 0.413327386302478 2824 5984176
SGTC_390 dec-rvkr-cmk 16.7 µM -0.219057903621041 0.427832785278372 no 1940 0.413302471188782 2848 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_474 dl-dihydrosphingosine 5 µM -0.219947138679156 0.427499986321996 no 1941 0.412956161868503 2949 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3207 9114163 49.47 µM -0.222696238112621 0.426471454638954 no 1942 0.411885964699332 3072 849233
SGTC_175 3793-3120 23.7 µM -0.222977441240963 0.42636627503796 no 1943 0.41177653190396 2815 5322297
SGTC_537 1334-0398 209 µM -0.223002342476534 0.426356961375301 no 1944 0.41176684168866 2957 5846986
SGTC_3182 9108849 49.47 µM -0.223309026395759 0.426242257562375 no 1945 0.41164750129372 2890 17133045
SGTC_2844 9010103 25.97 µM -0.223563550239681 0.426147067039803 no 1946 0.411548464236283 2990 2480525
SGTC_2348 9022543 33.42 µM -0.223907475074298 0.426018447872916 no 1947 0.411414649563762 2939 3162678 YDL140C RPO21
SGTC_2062 5245942 200 µM -0.224264250665074 0.42588503116548 no 1948 0.411275845793406 2766 1376160
SGTC_785 1270-0111 65.3 µM -0.224484457980156 0.42580268857977 no 1949 0.411190179539041 2777 6741994
SGTC_1692 fluoroquinolonic acid 71 µM -0.224788240994718 0.425689099667542 no 1950 0.41107200716009 2913 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2192 5915882 198.485 µM -0.226005483841752 0.425234016714239 no 1951 0.410598577592006 2795 2876149
SGTC_1473 k844-0725 134 µM -0.227392644426049 0.424715529139116 no 1952 0.410059219696488 2835 54682906
SGTC_2006 4011487 200 µM -0.227626723012024 0.424628048958304 no 1953 0.409968221650556 2953 45595294
SGTC_1893 st059353 36.1 µM -0.228846755090009 0.42417215703487 no 1954 0.409494012801588 2854 3112488
SGTC_2171 5739187 198.077 µM -0.229089220068509 0.424081566706658 no 1955 0.409399785913578 2757 2262761
SGTC_1937 st074714 47.2 µM -0.230256473289905 0.423645511067879 no 1956 0.408946240593568 2777 17250970
SGTC_162 k030-0015 37.8 µM -0.230457348815735 0.42357047857629 no 1957 0.408868201121275 2886 1809920 YMR134W ERG29
SGTC_1327 1436-0082 2.18 µM -0.231544592527625 0.42316441153459 no 1958 0.408445873332191 2841 15992205
SGTC_2327 6189656 200 µM -0.23166555134073 0.423119240511099 no 1959 0.408398894782329 2938 5349088
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.231891775604049 0.423034761727899 no 1960 0.408311036278164 2781 688667
SGTC_1563 conessine 56.1 µM -0.232463299794538 0.422821353583799 no 1961 0.408089094506023 2943 441082 An anti-amoebic, histamine inhibitor.
SGTC_2788 5282734 71.43 µM -0.233130477320448 0.422572256969532 no 1962 0.407830044680462 2980 743706
SGTC_2969 9091408 28.7 µM -0.233205350676808 0.422544304271874 no 1963 0.40780097557527 2809 4286311
SGTC_1284 0929-0043 16 µM -0.233470881910908 0.422445175834751 no 1964 0.407697888852555 2876 1239883
SGTC_215 1287-0124 461.5 µM -0.233576134930863 0.422405884010777 no 1965 0.407657028426474 2881 5560863
SGTC_3157 9099274 49.47 µM -0.234374921140071 0.42210771569694 no 1966 0.407346963255351 2907 17217662
SGTC_848 0368-0089 85.6 µM -0.235018903938008 0.421867364388426 no 1967 0.407097030439648 2938 762535
SGTC_2585 alliin 100 µM -0.236751173386601 0.421220980556945 no 1968 0.406424916337621 3026 87310 A garlic compound which reacts with lipids.
SGTC_288 1315-0019 35.1 µM -0.236954015042147 0.421145305508154 no 1969 0.406346232517718 2901 6811474
SGTC_3063 1327-0034 4 µM -0.237345079364935 0.420999417606561 no 1970 0.406194546371024 2899 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2491 paeonol 100 µM -0.23744362846641 0.420962655232948 no 1971 0.40615632333608 2784 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2597 laccaic acid a 100 µM -0.237607130803336 0.420901664477278 no 1972 0.406092909657026 2965 5491415 A textile dye.
SGTC_1557 sumaresinolic acid 42.3 µM -0.241381454426922 0.41949427119957 no 1973 0.404629742541823 2828 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1151 3909-8316 15.3 µM -0.241504753778299 0.419448311833872 no 1974 0.404581966264329 2937 800431
SGTC_1865 st057639 52.2 µM -0.241983466966277 0.419269883729299 no 1975 0.404396487018041 2801 688818
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.242252988393903 0.419169433808087 no 1976 0.404292069366015 2842 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1209 2323-2347 50.3 µM -0.242826150363694 0.418955835384704 no 1977 0.40407003835106 2832 5412760
SGTC_3055 9094636 49.47 µM -0.242949899269902 0.418909721412084 no 1978 0.404022104654584 2999 25236176
SGTC_2163 5671233 125 µM -0.246201418117995 0.417698471765554 no 1979 0.402763158921094 3046 701023
SGTC_839 0122-0028 230 µM -0.24632640111904 0.417651928836656 no 1980 0.402714787157532 2851 759448
SGTC_2709 st078560 56 µM -0.246551596771297 0.417568070222513 no 1981 0.402627634177589 2993 17250903
SGTC_38 0929-0051 58.268 µM -0.246614869957664 0.417544509155568 no 1982 0.402603147689362 2977 1379719
SGTC_2320 7373003 200 µM -0.247357919235431 0.417267841709696 no 1983 0.402315618992377 2885 5415828
SGTC_2110 5483698 200 µM -0.2487670637428 0.416743272533674 no 1984 0.401770484817837 2903 2848765 YHR062C RPP1
SGTC_119 0121-0043 24.815 µM -0.250064155671747 0.416260547110098 no 1985 0.401268867563254 2839 1092378
SGTC_822 1487-0950 154 µM -0.250559083497816 0.416076388134737 no 1986 0.401077509672215 2969 1958375
SGTC_1434 4073-0095 163 µM -0.250653429767663 0.416041284676768 no 1987 0.401041034513188 2867 24133745
SGTC_3338 9144300 39.5675 µM -0.250879276432347 0.415957256530531 no 1988 0.400953723563843 2920 4901274
SGTC_1568 digitonin 820 nM -0.251204691324727 0.41583618994672 no 1989 0.400827928842341 3002 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2783 7738165 71.43 µM -0.252336889837403 0.415415031810486 no 1990 0.40039033824709 2917 17201110
SGTC_1844 rapamycin 4 nM -0.252465306273265 0.415367269257936 no 1991 0.400340713646162 2819 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3294 9122953 26.2835 µM -0.253647623919641 0.414927582925336 no 1992 0.399883900460487 2833 16459826
SGTC_1570 verbenone 133 µM -0.254146822832827 0.414741970237655 no 1993 0.399691065596237 3033 29025 A natural terpanoid with antifungal properties.
SGTC_1339 1486-1321 22.7 µM -0.255500006051138 0.41423892400617 no 1994 0.399168469467937 2866 3469382
SGTC_2862 9027634 71.43 µM -0.255613831694768 0.41419661569409 no 1995 0.399124518500651 2821 5012562
SGTC_764 1951-2361 146 µM -0.256314298929423 0.413936278140242 no 1996 0.398854078507531 2870 5438930
SGTC_489 paxilline 115 µM -0.256951519119691 0.413699480001005 no 1997 0.398608099428077 2923 105008 A toxic potassium channel blocker.
SGTC_1275 0867-0008 21.1 µM -0.257018901436362 0.413674441812686 no 1998 0.398582090928614 2841 3422836
SGTC_3178 9107506 49.47 µM -0.257540375651592 0.413480682232891 no 1999 0.398380825439121 3004 8897194
SGTC_1876 myriocin 605 nM -0.257691998319412 0.413424349085174 no 2000 0.398322311008453 3017 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3061 glucosamine 200 µM -0.259198260560301 0.412864816717694 no 2001 0.397741136564214 2917 91431 and experimental redox chemotherapeutic
SGTC_2724 maprotiline 69.64 µM -0.259532146407854 0.412740811814641 no 2002 0.397612341116547 2923 4011 A tricyclic antidepressant.
SGTC_986 1493-0483 84 µM -0.260026378652516 0.412557270392219 no 2003 0.397421713025552 2955 40079
SGTC_2189 6047310 154.431 µM -0.260215805978796 0.412486928447664 no 2004 0.397348656356925 2834 711535
SGTC_3173 9105693 49.47 µM -0.26031816434023 0.412448919862662 no 2005 0.397309181180955 3025 17096658
SGTC_3056 9094900 49.47 µM -0.261335853290693 0.412071067586991 no 2006 0.396916760016133 2906 25236784
SGTC_56 0957-0365 83.25 µM -0.263414706283556 0.411299475040005 no 2007 0.396115478388552 2992 6752360
SGTC_1700 st030840 7.9285 µM -0.263420628721156 0.41129727734102 no 2008 0.396113196245004 2968 5499307
SGTC_2963 9082507 9 µM -0.263871653103663 0.411129919331741 no 2009 0.395939409626478 3033 16459611
SGTC_2469 5655019 90.81 µM -0.264085555457425 0.411050553948662 no 2010 0.395856996993886 2998 2788239
SGTC_3293 9120939 62.045 µM -0.264524691105997 0.410887630413202 no 2011 0.395687820718653 3029 934087
SGTC_1112 tnp00069 1.16933 µM -0.264608141943721 0.410856671089705 no 2012 0.395655673643843 2974 145826
SGTC_137 0438-0332 85.389 µM -0.267361355712113 0.409835572197387 no 2013 0.394595475199345 2913 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_754 3474-0146 171 µM -0.268063743947388 0.409575171347436 no 2014 0.39432512646456 2866 24762078
SGTC_66 0109-0187 42.4 µM -0.268157164043144 0.409540540124989 no 2015 0.394289172968087 2781 759417
SGTC_1367 1812-0510 76.9 µM -0.268598082748721 0.409377099237635 no 2016 0.394119493919648 2923 1142582 YDR527W RBA50
SGTC_3269 9137823 49.47 µM -0.271458445867463 0.408317196157924 no 2017 0.393019227774851 2856 17682936
SGTC_1438 4092-1045 4 µM -0.272483030037925 0.407937700764678 no 2018 0.392625318936791 2891 1351342
SGTC_1683 st010134 710 nM -0.274167883707841 0.407313836277595 no 2019 0.39197780394225 2874 3818134
SGTC_2701 st077767 14.721 µM -0.274306620419975 0.407262475557947 no 2020 0.391924498607755 2924 5721188
SGTC_1487 3970-0795 2.82 µM -0.27452220197332 0.407182669826737 no 2021 0.391841672020976 2979 3765103
SGTC_1812 st052057 4.327 µM -0.275044139664553 0.406989470653905 no 2022 0.391641163493655 2859 3645418
SGTC_1115 galangin 695.678 nM -0.275075174325316 0.406977983652519 no 2023 0.391629242068335 3024 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1654 st012436 41.8 µM -0.276137772577628 0.406584727623146 no 2024 0.391221124892638 2949 4323132
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.276439651304088 0.406473022761137 no 2025 0.391105202712416 3049 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_728 3030-5151 22.5 µM -0.277289310593326 0.406158662313654 no 2026 0.390778983397097 2886 3125388
SGTC_1711 st032263 62.8 µM -0.278421973001155 0.405739689299802 no 2027 0.390344227032771 2941 3958979
SGTC_3188 9110789 49.47 µM -0.279705994738232 0.405264858888803 no 2028 0.389851539353247 3063 849217
SGTC_64 000l-0018 272.079 µM -0.280557464082733 0.404950062902475 no 2029 0.389524922414285 2860 6811119
SGTC_3153 9100258 49.47 µM -0.281456560515365 0.404617725502355 no 2030 0.389180120786213 2924 25236848
SGTC_1179 1021-1431 9.29 µM -0.282166920412954 0.404355200347584 no 2031 0.388907760912068 2972 2840958
SGTC_2678 equilin 100 µM -0.284306433478208 0.403564768797813 no 2032 0.388087778143327 2999 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2868 9035608 32.47 µM -0.28553275688921 0.403111887539272 no 2033 0.387618006037116 2868 6462614
SGTC_1830 st055982 50.3 µM -0.287801803963083 0.402274271453952 no 2034 0.386749228202544 3014 455313 An antimicrobial agent.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.288080957221124 0.402171253262038 no 2035 0.386642384473846 2939 688664
SGTC_3213 9129884 49.47 µM -0.289415621312131 0.401678805371165 no 2036 0.386131671093443 3021 17190742
SGTC_2418 pentamidine 31.67 µM -0.289751186546747 0.401555017175305 no 2037 0.38600329700518 2980 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1111 tnp00062 510.699 nM -0.290305580970207 0.4013505257249 no 2038 0.385791234808438 3066 676306
SGTC_2902 5787006 60.46 µM -0.290445995004141 0.40129873751726 no 2039 0.385737530251327 2916 591003
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.291504015706209 0.400908568835738 no 2040 0.385332936542041 3042 688662
SGTC_2020 4017018 200 µM -0.291909612255515 0.400759022262858 no 2041 0.385177866953813 3029 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2330 7979373 200 µM -0.292150837094523 0.400670087701503 no 2042 0.385085649438901 2910 1863007
SGTC_1343 1487-0095 224 µM -0.2932235572681 0.400274660588999 no 2043 0.38467563948179 3052 4560101 YGL055W OLE1
SGTC_2224 6650123 117.647 µM -0.294979009814423 0.399627784682963 no 2044 0.384004957196274 2937 2908370
SGTC_1049 3226-0134 66 µM -0.295636328012824 0.399385636831355 no 2045 0.383753913663313 2967 5702385
SGTC_2254 7938975 95.19 µM -0.296229437411705 0.399167175916177 no 2046 0.383527434672767 3116 2969277
SGTC_2993 9054257 71.4286 µM -0.298084156693876 0.398484228306998 no 2047 0.382819466677444 2912 6470217 YGL055W OLE1
SGTC_2753 fluvastatin 17.09 µM -0.298777275258948 0.398229086775148 no 2048 0.382554995552584 3014 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_176 1486-1328 72.834 µM -0.301967002206534 0.397055489560099 no 2049 0.381338608920512 3006 22310231
SGTC_715 0868-0130 184 µM -0.302097165815446 0.397007618135889 no 2050 0.38128899646281 3110 2876258
SGTC_1658 st012944 20 µM -0.304235484951771 0.396221412205084 no 2051 0.380474246124917 3024 24207260
SGTC_1378 2093-0007 380 nM -0.305160817242616 0.395881321489784 no 2052 0.380121836622296 3057 3618014
SGTC_2589 lobaric acid 100 µM -0.307565678422886 0.394997825384682 no 2053 0.379206419815414 2969 73157 A novel microtubule depolymerizer.
SGTC_125 0133-0007 11.75 µM -0.307842001192138 0.3948963446098 no 2054 0.37910128008055 3086 26541
SGTC_690 glyoxal 20.3 µM -0.309792015812805 0.394180396079233 no 2055 0.378359561796188 2979 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_216 k038-0035 28.382 µM -0.310220471798335 0.394023136126811 no 2056 0.378196651855094 3050 4444231 YPR107C YTH1
SGTC_864 0469-0573 172 µM -0.310534617627392 0.39390784340885 no 2057 0.378077219319674 2939 689425
SGTC_3309 9129340 25.759 µM -0.312429184655316 0.393212727544532 no 2058 0.377357186744357 2993 17158987
SGTC_1086 cerivastatin 2.18 µM -0.312766585212762 0.393088971053821 no 2059 0.37722900186831 2985 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2457 5731572 11.68 µM -0.314749647177442 0.392361814627239 no 2060 0.376475872800948 3092 2865357
SGTC_1739 st037196 92.5 µM -0.315421600703667 0.392115505330018 no 2061 0.376220784144936 3152 612214
SGTC_1416 3966-0321 25.3 µM -0.315445047879449 0.392106911382473 no 2062 0.376211884045693 3014 582530 YLR208W SEC13
SGTC_2168 5727979 200 µM -0.315461833812901 0.392100758970986 no 2063 0.376205512467 2922 695210
SGTC_1114 scopoletin 1.73284 µM -0.316214511979801 0.39182491371761 no 2064 0.375919846750137 3098 5280460 A coumarin with genotoxic properties.
SGTC_1163 k060-0048 49.9 µM -0.316943192619824 0.391557914992923 no 2065 0.375643353635576 2967 6809982
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.317844637310245 0.39122768380655 no 2066 0.375301394694115 2983 97141
SGTC_2882 9058044 58.44 µM -0.318059905057871 0.391148835176838 no 2067 0.37521974833453 3046 18076804
SGTC_1751 st044839 27.194 µM -0.318088012310907 0.391138540335431 no 2068 0.375209088279262 2970 5291326
SGTC_3131 9127911 49.47 µM -0.320570218379604 0.390229684489993 no 2069 0.374268054833372 3207 45595681
SGTC_1987 st072290 61.9 µM -0.321172945294294 0.390009087267317 no 2070 0.374039666731383 3019 54697379
SGTC_1861 st057647 17.4 µM -0.322551777481867 0.389504569879055 no 2071 0.373517359549969 3148 688668
SGTC_1286 0929-0070 131 µM -0.322565223098212 0.389499651017001 no 2072 0.373512267438332 3075 1420408
SGTC_5 0352-0601 109.883 µM -0.322651882777625 0.389467948394647 no 2073 0.373479448293001 3028 762456
SGTC_943 3253-1379 105 µM -0.323211618958634 0.389263198405193 no 2074 0.373267491051218 3159 668464
SGTC_1946 st076057 65.1 µM -0.323401401854064 0.389193783308422 no 2075 0.373195634004809 2944 953009
SGTC_1792 st045773 43.6 µM -0.323952109575811 0.388992376173379 no 2076 0.372987145824128 2955 2919270
SGTC_702 1488-0190 94 µM -0.324388753723009 0.388832706043897 no 2077 0.372821866522462 3065 949357
SGTC_422 cantharidin 155 µM -0.325264262832496 0.388512610280087 no 2078 0.372490537845467 2922 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3033 9090887 49.47 µM -0.326329398084386 0.388123287191213 no 2079 0.372087574056459 2975 19325384
SGTC_1967 st070177 51.4 µM -0.326729395393113 0.387977111119689 no 2080 0.371936282538783 3130 5729214
SGTC_1933 st074711 15.9 µM -0.32705236656031 0.38785909526467 no 2081 0.371814139147557 2963 17250958
SGTC_2383 9036125 200 µM -0.328100041743382 0.387476338993564 no 2082 0.371418011216135 2981 79580
SGTC_692 k241-0027 77.8 µM -0.329042543923367 0.387132099905131 no 2083 0.371061765709396 3165 3600480
SGTC_646 4092-0839 27.3 µM -0.329072132590635 0.387121294388508 no 2084 0.371050583617886 3127 877796
SGTC_2009 4012297 12.05 µM -0.330106443038663 0.386743628492199 no 2085 0.370659767513682 3089 45595307
SGTC_124 0136-0217 7.121 µM -0.330195296317027 0.386711189793274 no 2086 0.370626200356646 3147 3976905
SGTC_610 4215-0184 155 µM -0.331370512365005 0.38628221456134 no 2087 0.370182317793096 3039 5605015
SGTC_761 k216-0224 480 µM -0.331747358901201 0.386144688121356 no 2088 0.370040018315148 3177 1340404
SGTC_2035 5154463 94.595 µM -0.333092039291961 0.385654076926888 no 2089 0.369532404167187 3146 2769623
SGTC_2497 7-hydroxyflavone 100 µM -0.333575452933133 0.385477746472107 no 2090 0.369349971993651 3157 5281894
SGTC_1402 3909-7673 35.9 µM -0.333625527657172 0.385459482516742 no 2091 0.369331076316122 2940 5328014
SGTC_2470 5664817 21.68 µM -0.334263329709478 0.385226876644757 no 2092 0.369090429591918 2970 2859561
SGTC_128 0906-2981 13.371 µM -0.334417324597344 0.385170721023232 no 2093 0.369032334037498 3172 6740226
SGTC_2846 9008642 19.48 µM -0.33501627495934 0.384952331290013 no 2094 0.368806404648576 3111 2992898
SGTC_1061 3448-9325 110 µM -0.335029349127325 0.384947564583738 no 2095 0.368801473461731 3037 723482
SGTC_2074 5212007 75.395 µM -0.335347037753903 0.384831743946046 no 2096 0.368681657412697 3102 758611
SGTC_2384 9036245 200 µM -0.335407636706231 0.384809652382006 no 2097 0.36865880400837 3040 6462766
SGTC_1730 st033808 45.1 µM -0.335943403869033 0.384614352830374 no 2098 0.36845677281711 2984 1045166
SGTC_950 1165-0508 94.1 µM -0.336138245688295 0.384543335727793 no 2099 0.368383309382544 3070 6148369
SGTC_3249 9135183 49.47 µM -0.336496914333859 0.384412616183748 no 2100 0.368248089031989 3156 4902779
SGTC_1120 ficusin 1.78878 µM -0.336702300480673 0.384337767541411 no 2101 0.368170664501041 3136 6199 A DNA cross-linker.
SGTC_1167 k781-0610 148 µM -0.338647041664321 0.383629261802702 no 2102 0.367437820090738 3029 4525169
SGTC_3236 9132701 49.47 µM -0.338797990793685 0.383574284434191 no 2103 0.367380957487818 3068 24282524
SGTC_3091 9116372 49.47 µM -0.3397515956365 0.383227025055296 no 2104 0.367021801386941 3162 17169793
SGTC_2376 9072922 81.32 µM -0.340251069524997 0.383045176868057 no 2105 0.366833730993496 3124 17087968
SGTC_968 1309-0633 340 µM -0.34174966431182 0.382499724087509 no 2106 0.366269646586436 3102 3761976
SGTC_1219 1469-0211 33.1 µM -0.341902134067874 0.382444241773266 no 2107 0.366212271782641 3130 6822282
SGTC_2154 5570129 200 µM -0.342900040324862 0.382081172674701 no 2108 0.365836830713593 3048 673366
SGTC_751 0833-0568 350 µM -0.342950717155658 0.382062737642833 no 2109 0.365817768054906 3105 6954252
SGTC_854 0422-0053 192 µM -0.344210401198668 0.381604580426586 no 2110 0.365344030343467 3037 3596728
SGTC_957 1187-1561 14.1 µM -0.344884239521159 0.381359568045115 no 2111 0.365090699775998 3071 1538454
SGTC_2103 5378138 10 µM -0.345100987134297 0.381280767180246 no 2112 0.365009225680995 3043 244142
SGTC_1935 st074532 41.6 µM -0.345408616420386 0.38116893378203 no 2113 0.364893600187291 3118 2829742
SGTC_669 0108-0021 26.2 µM -0.345692852845656 0.381065613280593 no 2114 0.364786778049908 3311 17201
SGTC_3076 9116187 49.47 µM -0.347083913199781 0.380560082506999 no 2115 0.364264139288896 3112 27241210
SGTC_2888 9058547 12.99 µM -0.348062165122809 0.380204694139441 no 2116 0.363896748849602 3012 16476514
SGTC_1488 4013-0813 75.9 µM -0.349577672431931 0.379654326437177 no 2117 0.363327834875816 3026 2910057
SGTC_245 methotrexate 289.6 µM -0.352399710101334 0.378630132770445 no 2118 0.362269259682203 3098 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1618 st003135 44.5 µM -0.353476543209979 0.378239545108324 no 2119 0.36186560552309 3105 1270615
SGTC_1968 st069590 43.6 µM -0.355499888622138 0.377505976335556 no 2120 0.361107564173419 3153 6384066
SGTC_101 0490-5701 117.494 µM -0.357897526098022 0.376637278998532 no 2121 0.360210001077016 3110 4661669
SGTC_356 1634-0012 32.5 µM -0.358063424203247 0.376577194855729 no 2122 0.360147925027937 3154 735457
SGTC_1579 chlormadinone acetate 49.4 µM -0.358587414307405 0.376387438392927 no 2123 0.359951881698622 3170 45114258 A steroidal progestin.
SGTC_2871 9038510 12.99 µM -0.360093707252898 0.375842119744829 no 2124 0.359388529237393 3241 4945164
SGTC_1310 1188-0297 994 nM -0.360496512071345 0.375696335503248 no 2125 0.35923793225152 3068 1588352
SGTC_366 0181-0206 4.31 µM -0.360623109908838 0.375650520525126 no 2126 0.359190605523718 3234 274874
SGTC_207 4185-0010 4.486 µM -0.362052080177769 0.375133506709714 no 2127 0.35865655612789 3128 3761753
SGTC_156 3474-0145 5.642 µM -0.362187538806915 0.375084508227532 no 2128 0.358605945461026 3156 2265471
SGTC_1548 st061468 90.8 µM -0.362249903536024 0.375061950157247 no 2129 0.358582645303004 3146 390799
SGTC_976 1348-1067 47.6 µM -0.363032759751589 0.374778818053195 no 2130 0.358290206295581 3037 5310671 YGL099W LSG1
SGTC_763 3453-1109 128 µM -0.363186662399354 0.374723164704038 no 2131 0.358232725127648 3206 1560353
SGTC_462 ag-879 158 µM -0.365973033988921 0.373716026072707 no 2132 0.357192598776404 3150 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1273 0849-0096 14.1 µM -0.368294217383185 0.372877688058752 no 2133 0.356326931920713 3106 5286025
SGTC_3242 9133940 49.47 µM -0.369630747071132 0.372395248510759 no 2134 0.3558288191521 3183 17248444
SGTC_605 1315-0399 119 µM -0.370425933645389 0.372108309444518 no 2135 0.355532576843541 3200 24020461
SGTC_1950 st077106 7.18 µM -0.371062273137029 0.371878740682566 no 2136 0.355295574964404 3134 13831864
SGTC_622 1348-1566 26.3 µM -0.372173374145008 0.37147800400414 no 2137 0.354881884418438 3133 7340407
SGTC_603 3794-0023 45.9 µM -0.372712215968607 0.371283712039649 no 2138 0.354681321761028 3158 3802260
SGTC_1020 4335-0961 93.3 µM -0.372762186219967 0.371265695763189 no 2139 0.354662724341953 3015 669075
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.373126412482052 0.371134386135525 no 2140 0.354527180789297 3118 75037 A free radical scavenger.
SGTC_2479 5617353 43.85 µM -0.375166846455987 0.370399053546543 no 2141 0.353768192563897 3224 2731746
SGTC_106 0092-0003 11.579 µM -0.376118743066426 0.370056170323687 no 2142 0.353414310357965 3101 1072148
SGTC_559 1550-0661 158 µM -0.376482023665119 0.369925340019159 no 2143 0.35327928859027 3144 5830875
SGTC_349 k015-0014 24 µM -0.376611273416054 0.369878796202197 no 2144 0.353231254337139 3005 2196908
SGTC_2769 toremifene 3.73 µM -0.378317645887902 0.369264497440852 no 2145 0.35259731917053 3268 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3319 9138450 16.7555 µM -0.378651746163002 0.36914425944138 no 2146 0.352473245277082 3056 2029690
SGTC_1282 0886-0010 32.4 µM -0.37895853536766 0.369033861587426 no 2147 0.35235932764313 3250 2836211 YNL267W PIK1
SGTC_547 1120-0019 610 nM -0.37922068635632 0.368939535319478 no 2148 0.352261995661302 3057 3676939
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.379277647328271 0.368919040861939 no 2149 0.352240848348733 2988 4000243
SGTC_2175 5807670 165.306 µM -0.379719978617955 0.368759903530578 no 2150 0.352076644126477 3193 241186
SGTC_774 k060-0086 136 µM -0.380048490980273 0.368641729343347 no 2151 0.351954710126218 3265 5911235
SGTC_1355 1499-0035 1.68 µM -0.380260885759938 0.368565332191693 no 2152 0.351875883614543 3063 1548538
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.381021095823795 0.368291931699641 no 2153 0.35159379748191 3050 3256 An antibiotic and ribosome inhibitor.
SGTC_1184 1269-1718 139 µM -0.381395498982694 0.368157306562498 no 2154 0.351454900188929 3219 5403821
SGTC_992 3909-8734 162 µM -0.38171056928584 0.368044028440642 no 2155 0.351338029756871 3102 4288319
SGTC_1027 k015-0025 8.67 µM -0.381911361186098 0.367971843143061 no 2156 0.351263556454151 3034 3598955
SGTC_2048 5246248 200 µM -0.38333791262236 0.367459127931533 no 2157 0.350734616024742 3208 677046
SGTC_1466 k213-0079 57.5 µM -0.384023665898008 0.367212746132157 no 2158 0.350480453510415 3085 3657981
SGTC_2978 9011784 42.97 µM -0.384035508510205 0.367208491723016 no 2159 0.350476064839911 3165 2994934
SGTC_2460 5552655 174.22 µM -0.386365131500553 0.36637190202435 no 2160 0.349613135027765 3201 5401989
SGTC_1764 st044502 93.5 µM -0.387932192377213 0.365809512369496 no 2161 0.349033106999268 3213 8407
SGTC_641 4092-0595 30 µM -0.388100484902701 0.365749132361943 no 2162 0.348970836560527 3171 786260
SGTC_204 PMA1.184 62.41 µM -0.388200518408588 0.365713243907451 no 2163 0.348933824780199 3103 2252213 YGL008C PMA1
SGTC_2309 7664088 163.95 µM -0.388656083706254 0.365549818193628 no 2164 0.348765286611068 3266 704922
SGTC_3059 1327-0034 3 µM -0.390332452636273 0.36494866184122 no 2165 0.348145364491144 3085 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_926 2268-1401 59.4 µM -0.39081244784346 0.364776593608424 no 2166 0.347967936621514 3128 2931578
SGTC_1450 4112-4260 37.6 µM -0.391300461950281 0.364601678687764 no 2167 0.347787578724096 3233 1633175
SGTC_2620 irigenin 100 µM -0.391398936359327 0.364566386723874 no 2168 0.347751189201927 3259 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2381 9035592 200 µM -0.392299315798795 0.364243755555538 no 2169 0.347418534559066 3133 4749657
SGTC_1277 0873-0036 22 µM -0.392600590796276 0.364135821749932 no 2170 0.347307251566305 3201 5965735
SGTC_3244 9134489 49.47 µM -0.392764138834646 0.364077234070915 no 2171 0.347246846770298 3158 16584271
SGTC_2621 lithochol-11-enic acid 100 µM -0.393357614283966 0.363864660537464 no 2172 0.34702768527592 3212 6708711
SGTC_14 0354-0009 295 µM -0.393952666889424 0.363651564148344 no 2173 0.346807992722689 3101 1713507
SGTC_2851 9015922 71.43 µM -0.394013062738972 0.363629937933874 no 2174 0.346785697540623 3261 2996893
SGTC_1610 st001799 48.1 µM -0.394927654006827 0.363302499257085 no 2175 0.346448140242127 3032 621897
SGTC_2784 7567673 72.73 µM -0.396447305668522 0.362758659948872 no 2176 0.345887536949323 3173 3471247
SGTC_2981 9013952 38.96 µM -0.396620457693772 0.362696711395883 no 2177 0.345823682141819 3129 2996344
SGTC_2343 7990716 14.84 µM -0.39910636312898 0.361807726574934 no 2178 0.34490741694788 3071 6456862
SGTC_796 1234-0020 70.7 µM -0.399506061247521 0.361664859920824 no 2179 0.344760179246916 3095 46495034
SGTC_1337 1486-1011 40.3 µM -0.399812039314793 0.361555505252381 no 2180 0.344647481299385 3190 X1337
SGTC_1089 terbinafine 2.25 µM -0.401879941443846 0.360816746670539 no 2181 0.343886192739304 3212 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3044 9093193 49.47 µM -0.40231151599797 0.36066263192051 no 2182 0.343727390246361 3191 25236277
SGTC_2800 7887935 81.82 µM -0.403653171344023 0.360183673034231 no 2183 0.343233889938481 3239 2961002
SGTC_3253 9135987 49.47 µM -0.405107754043832 0.35966464795262 no 2184 0.342699153520958 3213 4182430
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.406297675996518 0.359240251625441 no 2185 0.342261946388989 3137 115019
SGTC_1411 3909-8223 150 µM -0.406973769816532 0.358999194019075 no 2186 0.342013626696472 3225 X1411
SGTC_2398 5228213 48.84 µM -0.407029113425929 0.358979464037891 no 2187 0.341993302795639 3309 80771 YMR134W ERG29
SGTC_2517 totarol 10 µM -0.407498905315162 0.358811998516169 no 2188 0.341820798993048 3208 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3034 9090421 49.47 µM -0.410898341531751 0.357601020524359 no 2189 0.340573539288568 3183 17173761
SGTC_2038 4100038 30.985 µM -0.411093803593829 0.357531434683423 no 2190 0.3405018766964 3209 3596803
SGTC_2182 6325192 200 µM -0.411274973567851 0.357466941153494 no 2191 0.340435459178961 3237 736248
SGTC_2401 5128683 200 µM -0.41144316231476 0.357407072370173 no 2192 0.340373805052152 3117 708373
SGTC_710 3448-4187 58 µM -0.411859906359095 0.357258742498422 no 2193 0.3402210546549 3166 3946412
SGTC_1019 4262-0212 3.4 µM -0.414232801470747 0.356414579994577 no 2194 0.339351810817161 3207 4677213
SGTC_689 0833-0039 98 µM -0.416186548418159 0.355720057831092 no 2195 0.338636751058753 3177 5374726
SGTC_271 rotenone 740 µM -0.416438705060942 0.355630455473997 no 2196 0.338544505526051 3262 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_719 2810-4230 27.3 µM -0.416830676253101 0.355491186691128 no 2197 0.338401131386151 3178 721079
SGTC_2761 levamisole 97.89 µM -0.417381543112016 0.355295494315059 no 2198 0.338199676423181 3285 26879 An alkaline phosphatase inhibitor.
SGTC_277 nystatin 15.5 µM -0.418193305390749 0.355007189842648 no 2199 0.337902895030763 3083 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1316 1272-0050 65.9 µM -0.419241816798455 0.354634924698392 no 2200 0.337519706942255 3165 7340392
SGTC_598 3937-0236 20.2 µM -0.420363087363893 0.354236980599311 no 2201 0.337110114701946 3202 1379313
SGTC_727 3032-0951 202 µM -0.421771304398901 0.35373742331023 no 2202 0.336595976411868 3173 3652836
SGTC_2417 cerulenin 830 nM -0.421931686945916 0.353680544432168 no 2203 0.336537440291605 3266 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1508 1080-0625 72.9 µM -0.422742154276983 0.3533931661788 no 2204 0.33624169805866 3182 767111
SGTC_1249 0481-0015 10.2 µM -0.422865244622535 0.353349527692147 no 2205 0.336196790838617 3092 4227577
SGTC_272 doxorubicin 8.13 µM -0.423921814436374 0.352975027644057 no 2206 0.33581141721935 3219 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2838 9002687 71.43 µM -0.424099611602683 0.352912021613398 no 2207 0.335746584376519 3104 6457060
SGTC_2004 4023728 41.89 µM -0.424783848030321 0.352669586203398 no 2208 0.335497126624034 3291 360084 YDR527W RBA50
SGTC_2737 bleomycin 30.5 nM -0.427946474688843 0.351549797955058 no 2209 0.334345045011745 3223 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_734 2023-0417 80 µM -0.428262165324158 0.351438092156347 no 2210 0.334230130607435 3234 3935732
SGTC_2774 tamoxifen 10.92 µM -0.428940037053566 0.35119827346882 no 2211 0.333983431333709 3236 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_491 tetrandrine 80.3 µM -0.42965466862497 0.350945513965038 no 2212 0.333723431636613 3227 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_379 3970-0972 5.9 µM -0.430458032914901 0.350661449137775 no 2213 0.333431244205209 3219 2898042 YBL034C STU1
SGTC_1546 5-methoxyflavanone 78.7 µM -0.431005421801223 0.350467943494459 no 2214 0.333232214111116 3231 147795
SGTC_3197 9113331 49.47 µM -0.431392630683067 0.350331085984132 no 2215 0.333091453668717 3348 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3069 9117009 49.47 µM -0.432020490599788 0.350109212581461 no 2216 0.332863260327999 3171 41904981
SGTC_2741 miltefosine 3.04 µM -0.432550144937569 0.349922082883144 no 2217 0.332670807560454 3161 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2 0422-0095 29 µM -0.432791034181719 0.349836987484441 no 2218 0.332583293733316 3197 6790840
SGTC_2446 5162541 200 µM -0.435843766664425 0.348759248308605 no 2219 0.33147504346683 3135 1549321
SGTC_2108 5365811 200 µM -0.436257817339338 0.348613165230031 no 2220 0.331324841672743 3259 780283
SGTC_672 1441-0018 53.7 µM -0.438589388161534 0.347790972865859 no 2221 0.33047954380493 3151 251141
SGTC_892 0929-0076 29 µM -0.438918190966761 0.347675083104604 no 2222 0.330360407624272 3204 5751038
SGTC_3118 9124250 49.47 µM -0.439811593942189 0.347360266397893 no 2223 0.330036784893881 3184 1504786
SGTC_2691 st077356 60.2 µM -0.439895392619215 0.347330742876542 no 2224 0.33000643651388 3319 2839272
SGTC_3298 9116858 71.43 µM -0.440109937760492 0.347255159651575 no 2225 0.329928742325602 3294 2506942
SGTC_1210 3013-0140 750 nM -0.440657256650188 0.347062369350512 no 2226 0.329730572530886 3278 905973
SGTC_1177 0983-0204 23.6 µM -0.440831385136024 0.347001041771564 no 2227 0.329667535197858 3310 766818
SGTC_1334 1486-0610 236 µM -0.443344954574746 0.346116216597218 no 2228 0.328758122149967 3271 3742339
SGTC_1311 1190-0148 100 µM -0.443563322250898 0.346039386504922 no 2229 0.328679164162349 3317 1961333
SGTC_2292 7671323 168.05 µM -0.448682644669108 0.344240035084843 no 2230 0.326830303069433 3322 937504
SGTC_2265 7929201 200 µM -0.44933869553699 0.344009698422319 no 2231 0.326593673838432 3114 1265108
SGTC_2832 7992762 51.95 µM -0.45145637244478 0.343266586357791 no 2232 0.325830330956289 3077 2985177
SGTC_155 k072-0202 43.6 µM -0.453268758613079 0.342631084355963 no 2233 0.32517761307989 3273 5857737
SGTC_191 3914-0123 66.505 µM -0.455737248420417 0.341766239940853 no 2234 0.324289466671384 3158 3144412
SGTC_2634 4'-methoxyflavone 100 µM -0.455876534721489 0.34171746516826 no 2235 0.324239382098224 3248 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3089 9117425 49.47 µM -0.456738666850886 0.341415625682496 no 2236 0.323929447385778 3268 9401657
SGTC_2489 cantharidin 73.42 µM -0.458011135182679 0.340970309480636 no 2237 0.323472220664862 3282 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_382 3229-0966 23.2 µM -0.459265841618022 0.340531426106099 no 2238 0.323021637037737 3364 5722370
SGTC_2880 9042983 58.44 µM -0.460601050117725 0.340064620998371 no 2239 0.322542429029134 3313 6464714
SGTC_1016 4226-1401 38 µM -0.461605038609538 0.339713775796552 no 2240 0.322182290319127 3300 2901613
SGTC_1878 temozolomide 1 mM -0.463941653393785 0.338897780385258 no 2241 0.321344774467656 3316 5394 DNA alkylating agent.
SGTC_3127 9126946 49.47 µM -0.465002161099338 0.338527677592468 no 2242 0.320964954491438 3239 27243249
SGTC_3354 9151612 71.43 µM -0.465683707029505 0.338289909579312 no 2243 0.320720958188557 3331 27261949
SGTC_1562 morin hydrate 59.1 µM -0.465810316323538 0.338245747034375 no 2244 0.320675640055236 3363 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_795 0685-0265 78 µM -0.465968013601294 0.338190743812393 no 2245 0.320619198124186 3336 302754
SGTC_1159 4092-0538 61.2 µM -0.466966531161234 0.337842551145965 no 2246 0.320261911862042 3246 717301
SGTC_1511 0906-3109 28.5 µM -0.467413284202158 0.337686808967296 no 2247 0.320102110075016 3281 2882180
SGTC_2970 9090938 41.86 µM -0.46799422060911 0.337484330813382 no 2248 0.319894361338453 3376 17217104
SGTC_413 propylparaben 100 µM -0.468031463739971 0.337471351787733 no 2249 0.319881044743771 3213 7175 A pharmaceutical preservative.
SGTC_2994 9053520 71.4286 µM -0.468367600250765 0.337354218817599 no 2250 0.319760866810499 3326 4647384
SGTC_513 4245-1575 41.7 µM -0.4700226618733 0.336777712089875 no 2251 0.319169413430609 3247 719745
SGTC_260 nsc-65238 3.989 µM -0.470161860081774 0.336729242709283 no 2252 0.319119690461726 3309 3246252
SGTC_2466 5983409 37.09 µM -0.470337879344283 0.336667955971191 no 2253 0.3190568193094 3252 2879657
SGTC_1698 5-fluorocytosine 1.055 µM -0.470780957183738 0.336513703450026 no 2254 0.318898582320056 3332 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2131 toluylene red 5.2905 µM -0.471542638903115 0.336248596906157 no 2255 0.31862663904272 3211 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2552 juarezic acid 87.02 µM -0.471631343682663 0.336217728122552 no 2256 0.318594975115395 3256 1549512
SGTC_2540 epiandrosterone 100 µM -0.47245297198025 0.335931858425741 no 2257 0.318301750873905 3326 441302 A steroid.
SGTC_1507 4075-3230 155 µM -0.473609015094833 0.335529796257193 no 2258 0.317889372789953 3294 659771
SGTC_2170 morpholine 200 µM -0.476042720528854 0.334683989530216 no 2259 0.317021971500351 3339 121171 Reacts with secondary amines.
SGTC_2427 5545055 42.75 µM -0.477479268350168 0.334185126695069 no 2260 0.316510440062555 3245 5372858
SGTC_981 1488-1094 54.9 µM -0.481932901251919 0.3326403996967 no 2261 0.314926806369661 3277 3449522
SGTC_746 1095-0025 46.6 µM -0.482705924787456 0.332372567431997 no 2262 0.314652277909733 3381 6749286
SGTC_1239 0337-0584 35.4 µM -0.482713153322182 0.332370063339022 no 2263 0.314649711280213 3414 914301 YML130C ERO1
SGTC_919 tnp00227 403.569 nM -0.484264989646479 0.331832653027761 no 2264 0.314098909619017 3243 1269246 A methoxyflavone. YNL221C POP1
SGTC_2354 9060492 162 µM -0.484475653063262 0.331759725648455 no 2265 0.314024169587931 3365 6471895
SGTC_3108 9121785 49.47 µM -0.486822845681708 0.330947607190472 no 2266 0.313191939494473 3339 17140271
SGTC_285 1486-1325 46 µM -0.486927653980215 0.330911362484774 no 2267 0.313154800381772 3360 22310230
SGTC_8 0354-0001 70 µM -0.489955352891556 0.329865011883372 no 2268 0.312082746289454 3311 4993152
SGTC_834 0312-0008 75.7 µM -0.492032963698931 0.329147773580904 no 2269 0.311348020348117 3329 6385573 YIL048W NEO1
SGTC_1008 4106-0037 6 µM -0.493119807532506 0.328772820656864 no 2270 0.310963967990551 3315 2905394
SGTC_1540 guanosine 70.6 µM -0.493177834387907 0.328752806671006 no 2271 0.310943469125639 3325 6802 Guanosine is a purine nucleoside
SGTC_444 curcumin 90.4 µM -0.494943143053309 0.328144170758527 no 2272 0.310320127751546 3369 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2932 9016711 44.54 µM -0.496801967653633 0.327503785620897 no 2273 0.309664353766693 3369 7117328
SGTC_2285 7945142 200 µM -0.49690326321051 0.327468902764219 no 2274 0.309628635124063 3355 2970608
SGTC_3266 9136860 49.47 µM -0.497378387248101 0.327305305785127 no 2275 0.30946112180559 3334 4871271 YPR165W RHO1
SGTC_1503 4585-0012 61.3 µM -0.498003131205027 0.32709024143938 no 2276 0.309240917603861 3408 2922052
SGTC_2259 7964009 200 µM -0.499922376961296 0.326429911943388 no 2277 0.30856486763678 3393 313134
SGTC_2333 9017922 200 µM -0.501878640062793 0.325757405714295 no 2278 0.307876445624968 3381 3163164
SGTC_1080 nisoldipine 24.4 µM -0.501895593042985 0.325751580247251 no 2279 0.307870482708099 3227 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_80 0159-0065 512.242 µM -0.506087242544565 0.324312533724163 no 2280 0.306397702992265 3356 1548079
SGTC_1782 st039423 80.636 µM -0.506357081047922 0.324219984281005 no 2281 0.306302999140726 3284 2068169
SGTC_664 1222-0054 14.9 µM -0.506871005621762 0.324043748028395 no 2282 0.306122665431366 3348 6813991
SGTC_2483 5729050 27.16 µM -0.507584517076482 0.32379913433567 no 2283 0.305872375507561 3438 2865180
SGTC_158 k038-0087 26.446 µM -0.508107818416477 0.323619778885165 no 2284 0.305688866258961 3255 X158
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.508595855181779 0.323452546870999 no 2285 0.305517767418108 3265 688803
SGTC_109 0132-0036 33.701 µM -0.509639946167033 0.323094895568054 no 2286 0.305151866408955 3311 67274 A color developer.
SGTC_2173 5763948 167 µM -0.509680639589413 0.323080959424668 no 2287 0.305137609364578 3370 2867177
SGTC_960 1222-0186 7.7 µM -0.511231106003591 0.322550161398205 no 2288 0.304594619925401 3384 3126296
SGTC_560 2332-1943 155 µM -0.512387474689071 0.322154516925456 no 2289 0.304189927643195 3379 21177716
SGTC_1753 st043925 64 µM -0.513404100884411 0.321806850859811 no 2290 0.303834338787833 3370 670181
SGTC_2338 7999974 200 µM -0.513881221698546 0.321643738721689 no 2291 0.303667518551085 3360 315925
SGTC_1340 1486-1359 257 µM -0.514005498153049 0.321601258272561 no 2292 0.303624073318078 3292 4309068
SGTC_2827 7993847 71.43 µM -0.515248918572615 0.321176358086136 no 2293 0.303189544571911 3377 2985692
SGTC_797 k781-0471 270 µM -0.517056095535321 0.32055922893218 no 2294 0.302558500389811 3296 23738129
SGTC_3348 9149464 3.537 µM -0.517075766450932 0.320552514275945 no 2295 0.302551634785534 3369 1951442
SGTC_252 miconazole 1.30953 nM -0.517161965560697 0.320523090949758 no 2296 0.302521550127081 3360 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2748 diazoxide 86.69 µM -0.518282858186709 0.320140586621794 no 2297 0.302130465562238 3335 3019 A potassium channel activatior.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.518901647908989 0.319929506612642 no 2298 0.301914664278376 3316 4330530
SGTC_1959 st077091 55.8 µM -0.519038728044022 0.319882754062347 no 2299 0.301866867314498 3309 821356 YKL052C ASK1
SGTC_3237 9133362 49.47 µM -0.520322311074626 0.319445114141783 no 2300 0.301419473964864 3382 43845137
SGTC_718 1130-0073 349 µM -0.52042354929989 0.31941060747624 no 2301 0.301384200044931 3481 6740020
SGTC_72 0744-0168 198.391 µM -0.520601547752049 0.319349941170377 no 2302 0.301322185455935 3211 677577
SGTC_2549 cedrol 20.94 µM -0.522034483865413 0.31886173713236 no 2303 0.300823160547063 3397 6708665 A sedative which affects the nervous system.
SGTC_3100 9120536 49.47 µM -0.522767986662413 0.31861195284642 no 2304 0.300567860033464 3337 16421196
SGTC_1032 k061-1018 98.7 µM -0.523611774637318 0.318324714381542 no 2305 0.300274295095616 3459 4005393
SGTC_57 miconazole 162.5 nM -0.524993685201265 0.31785452657764 no 2306 0.299793790390692 3367 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2739 tacrine 100.86 µM -0.526049568484057 0.317495465606324 no 2307 0.299426883587507 3383 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2828 7998861 71.43 µM -0.526485299733239 0.317347341961317 no 2308 0.299275531563665 3380 2988188
SGTC_82 0054-0107 293.755 µM -0.526772346541892 0.317249778481001 no 2309 0.29917584431174 3374 3104697
SGTC_1052 3253-3998 198 µM -0.52837515628253 0.316705237847957 no 2310 0.298619488625057 3340 5450317
SGTC_536 3852-0578 10.6 µM -0.528639812169666 0.316615361470714 no 2311 0.298527668470022 3449 2869208
SGTC_259 usnic acid 108.925 µM -0.528859931477212 0.316540617833907 no 2312 0.298451309694873 3483 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2636 apigenin dimethyl ether 100 µM -0.529191483840089 0.316428050167692 no 2313 0.298336311881002 3435 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.529638934081091 0.316276160162327 no 2314 0.298181147268845 3374 442882
SGTC_2187 6125751 200 µM -0.531521918379923 0.315637308319441 no 2315 0.297528578349887 3384 874498
SGTC_2116 5511452 16.8835 µM -0.531642616815197 0.315596376963101 no 2316 0.297486771224994 3425 870744
SGTC_2092 5303694 80.6725 µM -0.532002548495678 0.315474330056998 no 2317 0.297362115209209 3331 1963699
SGTC_1403 3909-7815 62.9 µM -0.53260930284559 0.315268635216257 no 2318 0.297152030532823 3329 6615483
SGTC_202 3594-0513 34.79 µM -0.533977090481045 0.314805153745147 no 2319 0.296678692191041 3377 708429
SGTC_2102 5377816 72.7585 µM -0.534033223026323 0.314786139183455 no 2320 0.2966592742684 3463 1379702
SGTC_2157 5649910 96.377 µM -0.535185102968922 0.314396055274854 no 2321 0.296260933210367 3344 2858091
SGTC_737 1950-0117 57.9 µM -0.538443937905407 0.313293574646226 no 2322 0.295135299711593 3433 5393513
SGTC_1468 k284-1086 134 µM -0.541241867147885 0.312348349757839 no 2323 0.294170441728947 3411 15996457
SGTC_3101 9120531 49.47 µM -0.541476672246485 0.312269081533014 no 2324 0.294089536185972 3505 24824904
SGTC_139 0099-0334 718.624 µM -0.541534480211717 0.312249567383283 no 2325 0.294069619180859 3431 97690
SGTC_328 k915-0120 63.5 µM -0.541874389671461 0.312134835301879 no 2326 0.293952520277771 3421 6624543
SGTC_965 1291-5240 308 µM -0.542285951117828 0.311995942395546 no 2327 0.293810766110899 3451 2834598
SGTC_1513 0337-0559 19 µM -0.542295315201046 0.311992782534983 no 2328 0.293807541206397 3313 775073
SGTC_144 4161-2749 112.381 µM -0.543239060869151 0.311674391524354 no 2329 0.29348260787053 3373 797501 YMR168C CEP3
SGTC_1226 3909-7979 35.4 µM -0.543358660248142 0.311634052383742 no 2330 0.293441441474651 3437 6615510
SGTC_2764 methyldopa 94.69 µM -0.543568314931544 0.311563344346145 no 2331 0.293369284280099 3490 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1280 0880-0253 10.1 µM -0.544269778122618 0.311326819735371 no 2332 0.293127920341229 3378 6836607
SGTC_136 0097-0015 404.482 µM -0.546397662372128 0.310609800472949 no 2333 0.292396308314023 3451 4861337
SGTC_2291 7917025 104.35 µM -0.546409753924041 0.31060572811322 no 2334 0.292392153407293 3317 2964612
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.548220598103115 0.309996109249341 no 2335 0.291770220119302 3438 229346 A bile salt which induces apoptosis.
SGTC_1432 4049-0298 68.4 µM -0.54866103133347 0.309847916699808 no 2336 0.291619046850502 3447 741646
SGTC_1396 3511-0007 98.6 µM -0.549756603856222 0.309479423504399 no 2337 0.291243163586673 3415 X1396
SGTC_3328 9140624 29.0385 µM -0.551011946873965 0.309057427278252 no 2338 0.290812742444035 3458 4904392
SGTC_2617 dihydrotanshinone i 20.83 µM -0.551431671525871 0.30891638875249 no 2339 0.290668897257779 3377 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2207 7258803 200 µM -0.551673502959797 0.308835139817643 no 2340 0.290586033543113 3428 3666799
SGTC_921 1561-0023 372 µM -0.552896986422984 0.308424225336475 no 2341 0.290166975560153 3441 24050882
SGTC_1978 st071761 42 µM -0.553329985384814 0.308278857401577 no 2342 0.290018736012932 3357 5147680
SGTC_3313 9133968 57.047 µM -0.553755011073227 0.308136195516964 no 2343 0.289873260696847 3428 1494643
SGTC_980 1473-0395 201 µM -0.553876680202013 0.30809536203259 no 2344 0.289831622798428 3389 768876
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.555602201168046 0.30751651431959 no 2345 0.289241413185146 3396 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_947 3447-0010 211 µM -0.55676423669766 0.307126964673961 no 2346 0.288844260797652 3461 748350
SGTC_2820 7989630 71.43 µM -0.55815883412497 0.306659740464744 no 2347 0.288367964183448 3384 2984098
SGTC_1591 genipin 88.4 µM -0.5601128085489 0.306005639558836 no 2348 0.287701247183779 3471 442424 A DNA cross-linking agent.
SGTC_1312 1218-2183 165 µM -0.561779938994292 0.305448049383895 no 2349 0.287132980909521 3472 6744073
SGTC_711 k292-0785 179 µM -0.564943810068315 0.304391098618215 no 2350 0.286055991911703 3471 4146315
SGTC_359 0081-0058 15.9 µM -0.565328538529916 0.304262683923694 no 2351 0.285925160467956 3627 3494159
SGTC_897 1000-0139 31.4 µM -0.565441346819457 0.304225035339488 no 2352 0.285886804074589 3479 6151020
SGTC_3336 9143619 71.43 µM -0.566510098235558 0.303868453765634 no 2353 0.285523535105902 3497 45595730
SGTC_652 0437-0092 114 µM -0.568655576058924 0.303153193198383 no 2354 0.284794950492509 3471 3091274
SGTC_146 3448-8650 53.125 µM -0.568956422943584 0.303052956921924 no 2355 0.284692856612912 3436 2891488 YIL048W NEO1
SGTC_1412 3909-8563 178 µM -0.570206277878047 0.3026366886508 no 2356 0.284268899315467 3526 23767530
SGTC_1975 st070967 30.8 µM -0.571105717648363 0.302337285920616 no 2357 0.283963991525704 3502 261391
SGTC_2118 5526350 200 µM -0.571518129404874 0.302200048014851 no 2358 0.28382423733981 3442 743594
SGTC_2710 st078562 53.7235 µM -0.572054900208266 0.302021469145384 no 2359 0.28364239087274 3428 17250908
SGTC_2458 5808907 16.39 µM -0.572605491524114 0.301838341570706 no 2360 0.283455920316323 3554 2731747
SGTC_1162 k048-0130 20.1 µM -0.572864120434772 0.30175233839999 no 2361 0.283368349907431 3414 6797406
SGTC_954 1189-0853 2.85 µM -0.574615617118812 0.301170194578095 no 2362 0.282775643836275 3474 2828194
SGTC_3164 9100705 49.47 µM -0.575374355539696 0.300918170345334 no 2363 0.28251907194196 3516 17174235
SGTC_1173 0443-0020 122 µM -0.577447525298913 0.300230027147457 no 2364 0.281818588617163 3431 5331295
SGTC_2938 9059746 27.26 µM -0.577674108621238 0.300154860932101 no 2365 0.281742081332321 3449 6471769
SGTC_429 1112-0049 25.5 µM -0.577758593760435 0.300126836210172 no 2366 0.281713556956126 3333 2836170
SGTC_487 nimodipine 119 µM -0.578551572940707 0.299863853319162 no 2367 0.281445894480879 3410 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2122 5258151 111.688 µM -0.578891851907656 0.299751035508803 no 2368 0.281331074235066 3415 2173356
SGTC_755 1995-0008 37.3 µM -0.579211427946106 0.29964509915958 no 2369 0.281223260366549 3500 689533
SGTC_1231 0242-0792 125 µM -0.580000023190228 0.2993837601045 no 2370 0.280957301079285 3452 3707635
SGTC_518 1021-0119 62.6 µM -0.58088281604507 0.299091326814279 no 2371 0.280659717267658 3396 1097762
SGTC_2024 5144227 134 µM -0.581157045498971 0.299000512178354 no 2372 0.280567307326266 3475 3475211
SGTC_3252 9135871 49.47 µM -0.581340836603753 0.298939654382737 no 2373 0.280505381574657 3511 17682838
SGTC_1165 k072-0275 30.3 µM -0.582476334100456 0.298563787809644 no 2374 0.280122938894065 3538 6153523 YGL055W OLE1
SGTC_278 4092-0821 23.9 µM -0.582652644252463 0.298505445809452 no 2375 0.280063579199975 3480 877900
SGTC_1164 k060-0068 93.7 µM -0.582691810481787 0.298492486192578 no 2376 0.280050393632173 3514 5963676
SGTC_17 0960-0276 49.807 µM -0.582979447649552 0.298397318484704 no 2377 0.279953567915124 3499 6821114
SGTC_792 4534-1957 155 µM -0.583020412890615 0.298383765837907 no 2378 0.27993977933206 3419 1717904
SGTC_1795 st049545 62.3 µM -0.584825238139134 0.297786948675434 no 2379 0.279332616206777 3477 5291882
SGTC_2273 7815444 169.05 µM -0.585009800211084 0.297725948638886 no 2380 0.279270563566969 3500 2824616
SGTC_1138 3761-0006 1.03 µM -0.589504531309194 0.296242148092245 no 2381 0.277761436670037 3502 12061087
SGTC_36 0335-0881 14.2 µM -0.589673285523675 0.296186505074065 no 2382 0.277704854312648 3455 23828853
SGTC_360 0957-0399 1.01 µM -0.592491411883781 0.295257998882704 no 2383 0.276760784977379 3516 6752301 YPR165W RHO1
SGTC_1804 st050076 49.1 µM -0.592584990742155 0.295227189850315 no 2384 0.276729463150702 3507 3895976
SGTC_1395 3486-0190 4.35 µM -0.595800738845312 0.294169367300651 no 2385 0.275654175046183 3561 6748079
SGTC_1722 st034304 3.6505 µM -0.595898255946373 0.294137316359923 no 2386 0.275621599206066 3476 4036148 YLR033W RSC58
SGTC_632 0781-2353 4.65 µM -0.596497074970463 0.29394053793002 no 2387 0.275421603669043 3527 6811515 YHR007C ERG11
SGTC_1854 st056233 32.9 µM -0.596862888860256 0.293820357477485 no 2388 0.275299463089947 3487 5393174
SGTC_152 4469-0003 551.229 µM -0.598050627783229 0.293430307669131 no 2389 0.274903076150528 3530 697280
SGTC_750 4073-0104 132 µM -0.599919226616599 0.292817151587732 no 2390 0.274280034080884 3422 22330957
SGTC_3209 9113616 49.47 µM -0.599967127806891 0.292801441266044 no 2391 0.27426407168159 3568 16649353
SGTC_1560 lithocholic acid 53.1 µM -0.60007535521876 0.292765946982546 no 2392 0.274228008104898 3476 9903 A bile acid which acts as a detergent.
SGTC_891 0929-0073 133 µM -0.600156601507484 0.292739302746521 no 2393 0.27420093672667 3517 5603632
SGTC_3332 9141069 11.198 µM -0.600480045782947 0.292633242291075 no 2394 0.27409317772549 3487 17332883
SGTC_700 3453-2283 142 µM -0.602357066479809 0.292018102024767 no 2395 0.273468241068144 3574 565664
SGTC_1642 st009582 77.7 µM -0.603727498672199 0.291569362330137 no 2396 0.273012414293269 3540 6739311
SGTC_389 tpck 16.7 µM -0.603950457235645 0.291496386325239 no 2397 0.272938290494636 3495 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2440 5628896 157.78 µM -0.604249662013213 0.291398467753388 no 2398 0.272838833907656 3505 5522048
SGTC_453 enantio-paf c16 10 µM -0.605042635186182 0.291139031449625 no 2399 0.272575334173541 3538 13871343 A lipid and platelet activating factor
SGTC_873 0591-4978 488 µM -0.606448870290436 0.290679220244176 no 2400 0.272108362439332 3614 3305145
SGTC_1068 loratadine 26.9 µM -0.607822098786692 0.290230529622855 no 2401 0.271652735444049 3500 3957 A H1 histamine antagonist.
SGTC_2227 7312221 64.1025 µM -0.610411433254924 0.28938537063569 no 2402 0.270794648151945 3542 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_135 0933-0004 26.348 µM -0.61119315351229 0.289130444502388 no 2403 0.270535857697142 3515 21230617 YGL099W LSG1
SGTC_2036 5160441 105 µM -0.611537143345814 0.289018299736221 no 2404 0.270422018159241 3545 134534 YIL048W NEO1
SGTC_255 tunicamycin 200.472 nM -0.612162009734621 0.288814638241965 no 2405 0.270215286968598 3489 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2823 7987624 58.44 µM -0.61226210920413 0.288782019294372 no 2406 0.270182177342778 3605 2239440
SGTC_2076 5212012 200 µM -0.612895749520165 0.288575578127209 no 2407 0.26997263696547 3461 604802
SGTC_666 0272-0154 136 µM -0.61605025225093 0.287548871484754 no 2408 0.268930676975951 3525 6870312
SGTC_199 4063-0024 41.6 µM -0.616069408775606 0.287542641825177 no 2409 0.268924355580512 3555 306215
SGTC_2472 5377652 49.4 µM -0.616191994838994 0.287502778618434 no 2410 0.268883905594928 3515 1610903
SGTC_1985 st071382 65.5 µM -0.617009631112986 0.287236962046064 no 2411 0.268614186574204 3581 6123237
SGTC_776 4476-4378 112 µM -0.617081603243139 0.287213569211806 no 2412 0.268590451169978 3537 2892008
SGTC_2705 st078069 42.8 µM -0.618774805985707 0.286663494129753 no 2413 0.268032360807987 3501 1530061
SGTC_2792 7535235 81.82 µM -0.619832166145144 0.286320240432383 no 2414 0.267684144556398 3490 1281891
SGTC_1801 st050089 28.441 µM -0.620381444041358 0.286142003903758 no 2415 0.267503343058308 3558 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2730 imipramine 71.33 µM -0.620908315075323 0.285971087773998 no 2416 0.267329974932655 3571 3696 A tricyclic antidepressant.
SGTC_3029 9088683 49.47 µM -0.622503245803063 0.285453990762604 no 2417 0.266805505080777 3556 25236615
SGTC_1215 3852-0577 11.2 µM -0.622920951175718 0.285318638922225 no 2418 0.266668234692554 3604 2884876
SGTC_2240 6690706 185.951 µM -0.623946245105452 0.284986535814676 no 2419 0.266331444108277 3477 805876
SGTC_1030 k029-0042 36.7 µM -0.626086706797367 0.28429381330186 no 2420 0.265629035441186 3515 6080581
SGTC_2989 9073649 71.4286 µM -0.628801889414341 0.283416252274609 no 2421 0.264739381462371 3566 21367202
SGTC_2586 curcumin 80 µM -0.628832529574733 0.283406356631055 no 2422 0.264729350590697 3555 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_807 1315-0151 48 µM -0.629055720764348 0.283334279093493 no 2423 0.264656288848593 3626 4011080
SGTC_1329 1447-1697 50.6 µM -0.629760953306306 0.283106588530313 no 2424 0.264425498060224 3559 2840515
SGTC_713 1488-1073 324 µM -0.630112169764423 0.282993227953101 no 2425 0.264310598983299 3543 3312542
SGTC_2311 7694451 200 µM -0.631083043964333 0.282679976620813 no 2426 0.263993113633502 3491 2163142
SGTC_3205 9113483 49.47 µM -0.631418430153671 0.282571803427748 no 2427 0.263883484255144 3559 17018033
SGTC_3064 1327-0027 10 µM -0.631718333246286 0.282475091568813 no 2428 0.263785473075318 3470 16000455 YPR107C YTH1
SGTC_1261 0712-0010 12.7 µM -0.632276165925142 0.282295245692711 no 2429 0.26360321744642 3597 2840123
SGTC_3262 9137218 49.47 µM -0.633551636693228 0.28188423962847 no 2430 0.263186735946674 3443 17650664
SGTC_2743 auranofin 4.32 µM -0.633754556091546 0.281818877735394 no 2431 0.263120507360168 3524 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2014 4013930 200 µM -0.634100501466025 0.281707462922774 no 2432 0.263007617766568 3554 64556
SGTC_2115 tiliquinol 12.7705 µM -0.635254804961133 0.281335862835113 no 2433 0.262631122310453 3528 71208 A bioactive hydroxyquinoline.
SGTC_2521 angolensin 13.4 µM -0.637890722510587 0.280488181076696 no 2434 0.261772408698544 3584 821428 A flavenoid.
SGTC_2255 7941087 197.44 µM -0.638823037943201 0.28018865504609 no 2435 0.261469029684121 3611 935561
SGTC_804 1595-0054 20.9 µM -0.640864805634573 0.279533235873599 no 2436 0.260805261831305 3557 761523 Stimulates phospholipase C.
SGTC_471 1-acyl-paf 4 µM -0.640997211517732 0.279490758539111 no 2437 0.260762247331452 3539 16759367
SGTC_1452 4194-0072 190 µM -0.641077876192949 0.279464881917486 no 2438 0.260736043709331 3622 1343545
SGTC_1653 st012112 65 µM -0.643847804218961 0.278577016486144 no 2439 0.259837065636103 3597 720429
SGTC_2909 7941780 10.49 µM -0.645466506818025 0.278058798610401 no 2440 0.259312458210828 3594 1243215
SGTC_3186 9110464 49.47 µM -0.645766296124038 0.277962874513388 no 2441 0.259215359207552 3600 17018021
SGTC_2689 tacrolimus 100 µM -0.646471277953583 0.27773736393204 no 2442 0.258987096146586 3576 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_599 1935-0052 86.5 µM -0.647337369693631 0.277460439654387 no 2443 0.25870681037798 3563 9557311
SGTC_1958 st076513 41.9 µM -0.648215724815898 0.277179732196708 no 2444 0.258422716369351 3533 732122 YGL099W LSG1
SGTC_1534 6-azauridine 81.6 µM -0.648263529910933 0.277164458483635 no 2445 0.25840725899206 3601 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3152 9099253 49.47 µM -0.648464508422139 0.277100250416541 no 2446 0.258342279513338 3612 25236131
SGTC_2848 9016370 25.97 µM -0.649304916557002 0.276831838001044 no 2447 0.258070654248557 3616 7894410
SGTC_585 0kpi-0023 191 µM -0.649421039922428 0.27679476014053 no 2448 0.258033134086297 3555 64601
SGTC_2344 7990960 76.95 µM -0.650229542759273 0.276536674933146 no 2449 0.25777198037028 3579 140813
SGTC_1643 st009866 20.2 µM -0.650562231458855 0.276430510402665 no 2450 0.257664558770641 3595 3156273 YOR207C RET1
SGTC_1981 st071826 47 µM -0.651505858271539 0.276129497763527 no 2451 0.257359998334513 3552 11838600
SGTC_3124 9127567 49.47 µM -0.651663957043129 0.276079080720143 no 2452 0.257308989441281 3576 17592030
SGTC_1248 0469-0687 58.6 µM -0.654669410165201 0.275121514681819 no 2453 0.256340312155812 3590 4017482
SGTC_2745 rifampicin 24.3 µM -0.654692393838331 0.275114198170758 no 2454 0.256332911696814 3524 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_528 3492-0019 172 µM -0.654988210291844 0.275020037949604 no 2455 0.256237672391588 3630 2869262
SGTC_2041 5107442 45.335 µM -0.65527314196079 0.274929357436042 no 2456 0.256145954932297 3621 793005
SGTC_1573 oleylamine 1.06 µM -0.655904170102853 0.274728582954428 no 2457 0.255942892460392 3621 5356789 An amine of the fatty acid oleic acid.
SGTC_2174 5790901 200 µM -0.656541140918057 0.274525991036985 no 2458 0.255738002878547 3599 786020
SGTC_352 k048-0007 5.11 µM -0.657133870817741 0.274337536408436 no 2459 0.25554742088429 3585 6811911
SGTC_1866 st057638 64 µM -0.65950950124404 0.273582861689134 no 2460 0.254784323439138 3601 688802
SGTC_459 nigericin 15.3 µM -0.660254891395057 0.27334628294811 no 2461 0.254545136128581 3667 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1824 st053723 68.6 µM -0.660680856511768 0.273211131751721 no 2462 0.254408501555337 3586 675225
SGTC_693 4161-2696 114 µM -0.661526947052801 0.27294278041705 no 2463 0.254137219617282 3623 805759
SGTC_1895 st058434 18.3 µM -0.662188027996011 0.272733198868982 no 2464 0.253925362922581 3628 5393175
SGTC_1422 4031-0024 15.5 µM -0.663379505703519 0.272355668153159 no 2465 0.253543764097902 3583 782427
SGTC_533 1222-0222 6.71 µM -0.663418197658351 0.272343412603435 no 2466 0.253531377139944 3667 3982874
SGTC_2847 9005661 71.43 µM -0.665549916371056 0.271668621350008 no 2467 0.252849413958153 3531 2991449
SGTC_2699 st077704 54.6 µM -0.666047909935378 0.271511102513196 no 2468 0.252690238911569 3618 645852
SGTC_2555 cholic acid 100 µM -0.666341678664977 0.271418202753056 no 2469 0.252596365561267 3629 6708657 Influences liver metabolism.
SGTC_1743 st037606 46.3785 µM -0.666817003159328 0.271267922375546 no 2470 0.252444515260907 3641 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2443 5493264 126.67 µM -0.667512854707897 0.271047994165376 no 2471 0.252222300727998 3617 5340055
SGTC_1072 oxiconazole 14.9 nM -0.668919475010797 0.270603694842177 no 2472 0.251773423167192 3650 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3026 9090633 49.47 µM -0.668943212052792 0.270596200310919 no 2473 0.251765851875568 3607 25236842
SGTC_13 0199-0087 65 µM -0.66913611836796 0.270535297560918 no 2474 0.251704325922522 3650 4589825
SGTC_1242 0402-0103 60.1 µM -0.670265472560208 0.270178884866288 no 2475 0.251344286656851 3596 432868
SGTC_2297 7971671 152.32 µM -0.670532760693414 0.270094565830851 no 2476 0.251259114787746 3646 909016
SGTC_1459 k035-0031 35.7 µM -0.670609508158221 0.270070357416335 no 2477 0.251234661883362 3529 3877128 YMR208W ERG12
SGTC_869 0564-0080 44.1 µM -0.673312155920098 0.269218555403967 no 2478 0.250374360439467 3615 6843321
SGTC_1972 st070201 17.4 µM -0.673313272468594 0.269218203776547 no 2479 0.250374005344962 3620 2829099
SGTC_967 1306-0166 352 µM -0.673739283157853 0.269084059790972 no 2480 0.250238541188506 3617 4437607
SGTC_1363 1636-0063 10.4 µM -0.674580991310885 0.268819117934328 no 2481 0.249971006603444 3666 6072185
SGTC_2873 9040596 71.43 µM -0.675446008206927 0.268546975832001 no 2482 0.24969622162998 3628 6463863
SGTC_881 0833-0569 170 µM -0.675921340067988 0.268397491128956 no 2483 0.249545293998096 3621 5418700
SGTC_2747 doxorubicin 7.63 µM -0.67679919625544 0.268121528640569 no 2484 0.249266684089104 3533 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2977 9011197 71.43 µM -0.677047364193278 0.268043540576232 no 2485 0.249187951702742 3649 2704722
SGTC_2825 7998094 58.44 µM -0.677773889368314 0.267815291936862 no 2486 0.248957534403122 3618 2987815
SGTC_1290 0986-0249 10.2 µM -0.677862666763366 0.267787407918774 no 2487 0.248929386447854 3599 53329
SGTC_2567 aureobasidin a 60 nM -0.678671169981798 0.267533533152239 no 2488 0.248673118618612 3709 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3132 9126706 49.47 µM -0.67916902839059 0.267377263077928 no 2489 0.248515384483335 3653 850858
SGTC_2966 9084041 48.03 µM -0.67965376184367 0.267225156978541 no 2490 0.248361859901232 3580 17741380
SGTC_2267 7931562 200 µM -0.681124039965503 0.266764060861378 no 2491 0.247896503414229 3572 934880
SGTC_1810 st050138 53 µM -0.681494188263303 0.266648041490907 no 2492 0.247779421461596 3635 3444541
SGTC_569 4130-2812 160 µM -0.681540121869569 0.26663364582991 no 2493 0.247764894219351 3560 743552
SGTC_2750 bromebric acid 70.15 µM -0.682635423235563 0.266290493179675 no 2494 0.247418622286385 3678 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2386 9075165 157.42 µM -0.683222172557116 0.266106759423162 no 2495 0.247233231998688 3621 16452277
SGTC_2312 7706453 155.7 µM -0.684231458710581 0.265790863409079 no 2496 0.246914510127225 3680 976098
SGTC_1092 toremifene 6.32 µM -0.684876095288204 0.265589198421078 no 2497 0.246711055863112 3655 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2959 9079155 11 µM -0.685777687627847 0.265307278866128 no 2498 0.246426654229767 3640 16189457
SGTC_2283 7944793 200 µM -0.687031506700286 0.264915473959955 no 2499 0.246031437132567 3642 2970533
SGTC_346 4513-0042 7.16 µM -0.687461406670017 0.264781202597276 no 2500 0.245896006419114 3654 2827372
SGTC_1199 1638-0010 4.46 µM -0.688469334564251 0.264466530544262 no 2501 0.245578637404285 3641 3111136
SGTC_2654 protoveratrine a 100 µM -0.688576409477724 0.264433113264737 no 2502 0.245544935366319 3632 5702278 A heart drug and vasodilator.
SGTC_1908 st060353 56.5 µM -0.691513930508689 0.26351717391477 no 2503 0.244621314723109 3688 4227716
SGTC_623 k072-0108 16.9 µM -0.694972715102599 0.262440780454221 no 2504 0.243536200442171 3652 5382803
SGTC_3020 9089140 49.47 µM -0.695961932957761 0.262133344720164 no 2505 0.243226334849344 3671 17217859
SGTC_2276 7947513 42.08 µM -0.696176987584751 0.262066533037319 no 2506 0.243158998702416 3557 2105100
SGTC_686 1319-0111 510 µM -0.696682554061797 0.261909501529143 no 2507 0.243000739567208 3711 4562600
SGTC_2736 butenafine 14.65 µM -0.697928266476784 0.261522782965827 no 2508 0.242611028004734 3655 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_26 0302-0163 425.158 µM -0.699017597279455 0.261184851873561 no 2509 0.242270516787873 3696 3100915
SGTC_653 0203-0016 55.2 µM -0.700172245094793 0.260826903346358 no 2510 0.24190987125728 3708 295302
SGTC_671 0560-0003 407 µM -0.702240072420027 0.260186494328728 no 2511 0.241264729499985 3622 3238678
SGTC_2022 5136654 200 µM -0.702636139316655 0.26006392440005 no 2512 0.241141267311254 3678 1713771
SGTC_1681 tripelennamine 100 µM -0.703165573208465 0.259900128195786 no 2513 0.240976285544868 3674 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1126 isoteolin 1.0172 µM -0.703336106277488 0.259847380025362 no 2514 0.240923157240482 3664 133323
SGTC_2999 9069765 71.4286 µM -0.705192131156313 0.259273643967221 no 2515 0.240345338779615 3704 2097066
SGTC_1304 1165-0502 251 µM -0.706985304118941 0.258719959177736 no 2516 0.239787805221489 3701 767425
SGTC_1217 1183-1422 255 µM -0.709257320145629 0.258019300237616 no 2517 0.239082404319122 3734 2849664
SGTC_1369 1866-0067 208 µM -0.709812642066289 0.257848196281678 no 2518 0.238910164207946 3696 3531355
SGTC_1266 0828-0227 32.9 µM -0.710076374551666 0.257766956526281 no 2519 0.238828388016809 3688 3913820
SGTC_1351 1496-0003 46.5 µM -0.710644398070035 0.257592028554401 no 2520 0.238652311554724 3699 3891978
SGTC_3013 9080133 71.4286 µM -0.710670757149078 0.257583912535004 no 2521 0.23864414246781 3754 17050193
SGTC_3071 9117417 49.47 µM -0.711441848134311 0.257346550673 no 2522 0.238405237153794 3623 45595590 YGL055W OLE1
SGTC_1793 st048256 72.231 µM -0.711573524530655 0.257306028618894 no 2523 0.238364453260047 3611 672022
SGTC_3217 9129673 49.47 µM -0.711906728339942 0.257203503395547 no 2524 0.238261267712161 3690 17248312
SGTC_2776 terbinafine 19.92 µM -0.712105297498751 0.25714241471361 no 2525 0.238199787053544 3708 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2050 5263056 171 µM -0.712152957143051 0.257127753615608 no 2526 0.238185032045875 3708 763468 YGL055W OLE1
SGTC_2058 5236698 133 µM -0.712782111356484 0.256934253443779 no 2527 0.237990298369275 3712 766665
SGTC_3264 9137442 49.47 µM -0.712843767398871 0.256915294833232 no 2528 0.237971219496996 3721 17015726
SGTC_258 haloperidol 50.781 µM -0.712919059753289 0.256892144181624 no 2529 0.237947922135668 3716 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2711 st079103 59.1 µM -0.713563705438683 0.256693975038413 no 2530 0.237748503629147 3687 54693780
SGTC_3175 9106517 49.47 µM -0.714091568079595 0.256531765210379 no 2531 0.237585279772273 3714 41468073
SGTC_1096 rimcazole 32.2 µM -0.714687229657701 0.256348785214741 no 2532 0.237401165237274 3637 18528119 A dopamine reuptake inhibitor.
SGTC_2049 5262831 67.185 µM -0.71477906262663 0.25632058129616 no 2533 0.237372787325069 3734 763417
SGTC_1010 4112-3296 15.2 µM -0.716053451514736 0.255929355542851 no 2534 0.236979172329652 3726 704384
SGTC_2614 arthonioic acid 13.39 µM -0.716499311454332 0.255792554225105 no 2535 0.236841546255306 3661 6710684
SGTC_47 0149-0135 24.25 µM -0.717300039172979 0.255546966197186 no 2536 0.236594491536906 3693 5239155
SGTC_831 k061-1017 217 µM -0.719479800471588 0.254879044797801 no 2537 0.235922671846764 3758 1240153
SGTC_1152 3909-8331 15.9 µM -0.719530778754807 0.254863434998336 no 2538 0.235906972528972 3690 16001939
SGTC_3195 9113082 49.47 µM -0.719547003142803 0.254858467116408 no 2539 0.2359019761727 3660 17018038
SGTC_600 1495-0418 41.6 µM -0.719570307632584 0.254851331407206 no 2540 0.235894799576714 3714 5377768
SGTC_3086 9117350 49.47 µM -0.72016180173344 0.254670254117022 no 2541 0.235712689813185 3629 2679265
SGTC_1572 epiandrosterone 68.9 µM -0.720892145539944 0.254446763008606 no 2542 0.235487937877186 3654 441302 A steroid.
SGTC_3201 9113999 49.47 µM -0.721443027671809 0.254278256645822 no 2543 0.235318490742867 3720 16649224
SGTC_532 1548-0774 215 µM -0.721827169269157 0.25416078827749 no 2544 0.235200371566513 3797 5932993
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.722224918515843 0.254039188762437 no 2545 0.235078102701328 3746 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2659 sanguinarine 24.21 µM -0.722916692172022 0.253827773116037 no 2546 0.234865533840131 3663 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.724409270799631 0.253371935152952 no 2547 0.234407254966644 3708 16486 A toxic proline analog.
SGTC_1370 2001-0092 44.6 µM -0.725237252534317 0.253119252740734 no 2548 0.234153246355777 3784 790957
SGTC_1672 st016598 6.51 µM -0.725330786196217 0.253090716591679 no 2549 0.234124561640731 3737 4665860 YNL267W PIK1
SGTC_2127 5253358 187.912 µM -0.725539536875074 0.253027035030919 no 2550 0.234060549421228 3673 20612
SGTC_2770 toltrazuril 17.5 µM -0.726277972263977 0.252801835327777 no 2551 0.233834190179012 3685 68591 Kills coccidiodes.
SGTC_890 0929-0006 47.2 µM -0.728380776269903 0.25216112440629 no 2552 0.233190263836443 3708 1378169
SGTC_1851 st056236 18.9 µM -0.728538920714629 0.25211297345767 no 2553 0.233141876244628 3714 5393171
SGTC_2513 baicalein 25.65 µM -0.730348255966981 0.251562422396237 no 2554 0.232588669262203 3716 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_317 4495-0002 170 µM -0.733503539819809 0.250603843013973 no 2555 0.231625684821725 3744 15991618
SGTC_1689 st020265 53.493 µM -0.733941427114804 0.250470965344145 no 2556 0.231492218565753 3722 5758320 YPR016C TIF6
SGTC_3001 9076041 71.4286 µM -0.734473141284173 0.250309665952442 no 2557 0.231330211919181 3741 16004211
SGTC_3287 9117173 37.0625 µM -0.735495504871299 0.249999679274407 no 2558 0.231018888303182 3725 2789709
SGTC_1491 4138-0063 26.5 µM -0.736601182753345 0.249664660630516 no 2559 0.230682457747621 3686 23883227
SGTC_519 k048-0011 62.8 µM -0.736800909577352 0.249604169156658 no 2560 0.230621714993387 3784 6836379
SGTC_1634 st006576 41 µM -0.737851913011949 0.249285978963145 no 2561 0.230302221481605 3708 3915356
SGTC_784 4579-0127 173 µM -0.738046813878524 0.249226996643005 no 2562 0.230243000974404 3849 1948547
SGTC_1431 4049-0260 9.09 µM -0.739454900656714 0.248801091739659 no 2563 0.22981540781483 3709 3854841
SGTC_1849 st056239 19.2 µM -0.739576906630662 0.24876420676614 no 2564 0.229778379251713 3741 5393181
SGTC_1372 2752-0194 270 µM -0.739900367033728 0.248666431972926 no 2565 0.229680225853359 3709 823334
SGTC_545 4218-0007 221 µM -0.741498018726104 0.248183798222962 no 2566 0.22919576631801 3693 2840508
SGTC_2203 7227154 166.4 µM -0.742498399599666 0.247881848230827 no 2567 0.228892710545311 3751 896304
SGTC_2201 6605497 169.863 µM -0.743217350766987 0.247664964741967 no 2568 0.22867505015974 3727 670741
SGTC_1060 3448-7350 82 µM -0.743307101498331 0.247637897069529 no 2569 0.228647886547992 3691 570178
SGTC_1065 prochlorperazine maleate 2.48 µM -0.743507066764384 0.247577595785715 no 2570 0.228587372344775 3781 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_51 1013-0126 23.419 µM -0.745266545230967 0.247047347917489 no 2571 0.228055300637099 3797 1627850
SGTC_1309 pyrazolanthrone 13.4 µM -0.745988960292207 0.246829812287764 no 2572 0.227837041963594 3751 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_172 1112-0046 2.638 µM -0.746316201727206 0.246731306192397 no 2573 0.22773821328226 3712 2802135 YIL048W NEO1
SGTC_336 4111-0029 111 µM -0.747874705427295 0.246262454978546 no 2574 0.227267867991088 3707 3131175
SGTC_2669 eugenol 100 µM -0.748006565398513 0.246222808917802 no 2575 0.227228098725012 3713 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_544 k015-0020 52.4 µM -0.748255762445109 0.246147892711432 no 2576 0.227152951042186 3757 3008304
SGTC_197 4544-0043 41.561 µM -0.748420815074787 0.246098279604984 no 2577 0.227103185602551 3742 896523
SGTC_170 4197-0004 226 µM -0.748439072493679 0.246092791943957 no 2578 0.227097681139162 3774 218692
SGTC_2153 5569715 200 µM -0.749115978808586 0.245889379488374 no 2579 0.226893652484588 3758 2054701
SGTC_1399 3562-5772 25 µM -0.749364674834934 0.245814668230808 no 2580 0.226818718141474 3702 23847490
SGTC_3095 9117207 49.47 µM -0.750600005594979 0.245443740773182 no 2581 0.226446708891769 3742 17015229
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.7535322976378 0.244564479640304 no 2582 0.225565055299494 3784 364106
SGTC_2914 7968218 45.32 µM -0.753709044123657 0.244511535668295 no 2583 0.2255119750011 3744 2977111
SGTC_2068 5226020 147 µM -0.754227700901612 0.244356208965004 no 2584 0.2253562534227 3812 1810509
SGTC_2581 avocatin a 64 µM -0.754954883782381 0.24413852269349 no 2585 0.225138026500405 3781 6710728 A skin care supplement.
SGTC_490 phenamil 164 µM -0.755546293732136 0.243961557949522 no 2586 0.224960633224431 3731 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2738 aclarubicin 5.55 µM -0.75578976867956 0.243888724231508 no 2587 0.224887625997817 3701 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2252 omeprazole 400 µM -0.75653575108303 0.243665642217055 no 2588 0.224664022941642 3698 4594 A proton pump inhibitor.
SGTC_878 0828-0289 13.7 µM -0.757027566262455 0.243518627824832 no 2589 0.224516673750857 3761 745350 YLR208W SEC13
SGTC_1234 0326-0494 15.5 µM -0.757210349287574 0.243464002166456 no 2590 0.224461925429811 3801 1547813
SGTC_1104 tacrolimus 29.8 µM -0.757456684257197 0.243390394152369 no 2591 0.224388153617419 3795 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3042 9091578 49.47 µM -0.757814802242852 0.243283405406825 no 2592 0.224280929842418 3701 25236497
SGTC_1447 4239-0816 81.9 µM -0.757997800729468 0.243228743914436 no 2593 0.224226149666881 3778 1341554
SGTC_772 k072-0172 35.3 µM -0.759535232187224 0.242769776747623 no 2594 0.2237662232423 3798 5861980
SGTC_164 4100-3994 89.624 µM -0.760612557128805 0.242448444039826 no 2595 0.223444258634683 3767 4615967
SGTC_1748 st037455 53.6035 µM -0.761056190809012 0.242316188839935 no 2596 0.22331175286777 3771 580690
SGTC_370 0180-0345 38.7 µM -0.761141823721098 0.242290664627062 no 2597 0.223286180936544 3701 3989527
SGTC_477 mead ethanolamide 10 µM -0.761839626725652 0.242082727980892 no 2598 0.223077863254831 3648 16061185
SGTC_1079 idarubicin 2.36 µM -0.762775260821367 0.241804072544177 no 2599 0.222798718743701 3737 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1671 st016596 74.5 µM -0.763290077177246 0.241650821513456 no 2600 0.222645209270199 3825 2829167
SGTC_1706 st031321 9.9705 µM -0.76376023819009 0.241510909607899 no 2601 0.222505067949604 3798 6103185
SGTC_3090 9117696 49.47 µM -0.768793693796623 0.240015799245157 no 2602 0.221007896565025 3733 7923821
SGTC_2645 abamectin 100 µM -0.769431045573291 0.239826844362697 no 2603 0.22081873220175 3752 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2361 9034121 116 µM -0.770792718996972 0.239423422783854 no 2604 0.220414901812724 3789 6496917
SGTC_1620 st003704 16.5 µM -0.771771566223769 0.239133649840305 no 2605 0.220124867580269 3739 2834414
SGTC_2608 thymoquinone 42.66 µM -0.773222964313574 0.238704338390895 no 2606 0.219695218840879 3754 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2740 felodipine 17.08 µM -0.774313591123444 0.238382017783903 no 2607 0.219372684169705 3713 3333 L-type calcium channel blocker
SGTC_1192 1488-0095 21.4 µM -0.774897931526712 0.238209421665035 no 2608 0.219199987256078 3825 915875
SGTC_2329 6138490 200 µM -0.776282865146302 0.237800628585227 no 2609 0.218790993990089 3900 720019
SGTC_2248 tofa 1.1 µM -0.778373210320408 0.23718434736415 no 2610 0.218174513644159 3733 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1602 st001878 87.6 µM -0.77954343988671 0.236839720572329 no 2611 0.217829829446992 3817 595405 YLR310C CDC25
SGTC_468 gf-109203x 121 µM -0.779563523998 0.236833808305576 no 2612 0.217823916533595 3749 2396 A protein kinase C inhibitor.
SGTC_1727 st034309 9.9045 µM -0.780755103334285 0.23648318202713 no 2613 0.217473272329494 3912 870305
SGTC_2638 epoxomicin 18 µM -0.782082393396005 0.236092958987646 no 2614 0.217083076631469 3813 9915668 A protesome inhibitor.
SGTC_2034 5197015 53.07 µM -0.782832047387011 0.235872717708128 no 2615 0.216862872813761 3791 780676
SGTC_3179 9107801 49.47 µM -0.783023095131169 0.235816607795469 no 2616 0.216806774988773 3803 4818259
SGTC_337 1315-0038 354 µM -0.783402757137505 0.235705124519338 no 2617 0.216695318796359 3780 1626437
SGTC_1191 1487-1166 10.6 µM -0.786933658044686 0.234669710403726 no 2618 0.215660351567425 3877 3955771
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.787137234643672 0.234610089651303 no 2619 0.21560076730946 3821 551469
SGTC_1158 4092-0494 91.8 µM -0.787460643374374 0.234515391317738 no 2620 0.215506129355633 3935 1148199
SGTC_2053 5265679 138 µM -0.790501718933723 0.233625959384725 no 2621 0.214617409375016 3782 764595
SGTC_819 1013-0258 27.7 µM -0.790555825093558 0.233610151756728 no 2622 0.214601616772478 3834 5753198
SGTC_2920 7982904 15.77 µM -0.79132135715169 0.233386557870823 no 2623 0.214378244307856 3827 6456808
SGTC_114 0364-0001 490.298 µM -0.792915723839611 0.232921262286746 no 2624 0.213913462803644 3884 4003655
SGTC_2890 9046729 58.44 µM -0.794179680559151 0.232552759109345 no 2625 0.213545417956654 3765 903329
SGTC_3073 9114972 49.47 µM -0.795792214755528 0.232083100045223 no 2626 0.213076408770968 3764 41905075
SGTC_171 k064-0041 9.68 µM -0.799345280620285 0.231050116789474 no 2627 0.212045114923626 3845 53325
SGTC_29 0299-0004 12.984 µM -0.800700240757598 0.230656866017815 no 2628 0.211652601575592 3724 16871 A napthoquinone isolated from Swertia calycina.
SGTC_387 norethindrone acetate 66.7 µM -0.801300737757829 0.230482703129156 no 2629 0.211478781934606 3837 541197
SGTC_470 aa-861 153 µM -0.802152527926611 0.23023578350281 no 2630 0.211232366498849 3843 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3351 9150312 21.596 µM -0.802911782687819 0.230015813106069 no 2631 0.211012862620157 3788 4904905
SGTC_3190 9110366 49.47 µM -0.803449211044317 0.229860181109828 no 2632 0.210857570580945 3792 17123768
SGTC_3043 9092303 49.47 µM -0.804135196469652 0.229661614669303 no 2633 0.210659449792355 3846 25236084
SGTC_1448 4255-0083 152 µM -0.804686079694536 0.22950222471234 no 2634 0.210500427232405 3910 5399660
SGTC_2078 5212016 200 µM -0.80494132676862 0.229428393745777 no 2635 0.210426769368484 3738 1899708
SGTC_904 1141-0088 396 µM -0.805921844169984 0.229144900025842 no 2636 0.210143957521127 3859 1378119
SGTC_2353 9059630 146.67 µM -0.806701398366942 0.228919650390569 no 2637 0.209919269142899 3887 4779114
SGTC_1525 8-methoxypsoralen 92.5 µM -0.807833534785145 0.228592744651736 no 2638 0.209593208681306 3837 4114 Related to psoralen; DNA damaging agent.
SGTC_3307 9126885 69.2785 µM -0.808189757123417 0.228489939281398 no 2639 0.209490676661661 3824 24824909
SGTC_1906 st060206 94.7 µM -0.809222681582397 0.228191985334653 no 2640 0.209193535322378 3848 5133468
SGTC_656 4090-1979 187 µM -0.809935892361395 0.22798638248088 no 2641 0.208988510891307 3850 22330961
SGTC_1025 k007-0731 70 µM -0.812183752998889 0.227339056333946 no 2642 0.208343100363297 3821 6256118
SGTC_1443 4112-3303 14 µM -0.813696599504855 0.226903979024741 no 2643 0.207909391352196 3855 704433
SGTC_933 2914-0560 114 µM -0.819119556652888 0.225348263791965 no 2644 0.20635910253209 3906 463887
SGTC_2389 9091542 195.52 µM -0.819863749323565 0.22513524520472 no 2645 0.206146892151935 3857 3626624 YOL127W RPL25
SGTC_2027 5150920 200 µM -0.820733145726569 0.224886532699528 no 2646 0.205899143218994 3831 786715
SGTC_541 4513-1321 94 µM -0.820902838208279 0.224838006110644 no 2647 0.205850807140611 3864 747515
SGTC_2991 9074669 71.4286 µM -0.82141063186448 0.224692828934918 no 2648 0.205706204806993 3826 17333109
SGTC_639 0833-0042 114 µM -0.821595777425819 0.224639909423853 no 2649 0.205653496659634 3842 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.821671224674474 0.224618346627134 no 2650 0.205632020265591 3827 7104
SGTC_2002 4023503 131 µM -0.822995709929066 0.224240000490935 no 2651 0.205255216531279 3867 4736863 YCR052W RSC6
SGTC_1590 st077108 57.8 µM -0.823358888994714 0.224136319741118 no 2652 0.205151967170762 3847 5489485
SGTC_1715 st032160 10.2275 µM -0.82342854717498 0.224116436761255 no 2653 0.205132167347713 3803 5289825
SGTC_2684 capsaicin 100 µM -0.824173635140612 0.223903824214391 no 2654 0.204920452644975 3879 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1257 0669-0121 16 µM -0.825908938682081 0.223409095993694 no 2655 0.204427874807818 3891 4307855
SGTC_2213 7173844 200 µM -0.826249647220015 0.223312034425105 no 2656 0.204331245184824 3843 892728
SGTC_322 k048-0136 19.3 µM -0.827294976225887 0.223014389315368 no 2657 0.204034945266871 3921 6823282
SGTC_1405 3909-7894 12 µM -0.828379536164488 0.222705812618495 no 2658 0.203727796016454 3893 7104060
SGTC_1039 k821-0043 94 µM -0.828962114103927 0.222540159294747 no 2659 0.203562922803489 3831 15992768
SGTC_3068 9116768 49.47 µM -0.83063858067559 0.222063856016696 no 2660 0.203088916439185 3831 41904888
SGTC_522 1273-0010 11.6 µM -0.830734579528764 0.222036599274845 no 2661 0.203061793560197 4004 5705015
SGTC_991 3996-0057 64.7 µM -0.831053934920631 0.221945939152078 no 2662 0.202971580573276 3931 715343
SGTC_1597 7-benzyloxygramine 47.5 µM -0.832266717188557 0.221601841393552 no 2663 0.202629206338361 3853 260807
SGTC_205 1486-1330 71.903 µM -0.833726565317658 0.221188049310592 no 2664 0.202217542361854 3871 4118834
SGTC_1695 st026914 34.495 µM -0.834061856679575 0.221093073861676 no 2665 0.202123063929567 3826 3289191
SGTC_631 k072-0230 41.5 µM -0.834431826015527 0.220988302531243 no 2666 0.202018844591796 3900 5773147
SGTC_443 clozapine 122 µM -0.836167064449087 0.22049728106926 no 2667 0.201530462069535 3763 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_333 3486-0131 40.1 µM -0.836424519382997 0.220424482191398 no 2668 0.201458061741444 3957 6744690
SGTC_1733 st037357 54.9 µM -0.837098737855214 0.220233903053904 no 2669 0.201268534901383 3812 1272339 YGL099W LSG1
SGTC_3107 9121808 49.47 µM -0.837317592432181 0.220172060463091 no 2670 0.201207036561084 3789 662681
SGTC_280 3448-3607 3.04 µM -0.837522284288198 0.220114228902005 no 2671 0.201149528156914 3878 626179
SGTC_2268 7933382 153.85 µM -0.838218569977946 0.219917572645749 no 2672 0.200953979724607 3899 935025 YOR257W CDC31
SGTC_847 0342-0274 5.54 µM -0.839536050964709 0.219545744390563 no 2673 0.200584283843994 3892 18097
SGTC_1241 0364-0022 50.8 µM -0.842319911195708 0.218761253589487 no 2674 0.199804454385077 3922 4563895
SGTC_2447 5741742 33.78 µM -0.846106506171308 0.217696786245976 no 2675 0.198746665770551 3939 1776504
SGTC_1350 1495-0454 146 µM -0.847059696789118 0.217429301966517 no 2676 0.198480924043929 3931 1069057
SGTC_3054 9094397 49.47 µM -0.847530936711194 0.217297132777267 no 2677 0.198349625441084 3915 2598354
SGTC_1446 4239-0190 62 µM -0.848254554471698 0.217094269246413 no 2678 0.198148110464418 3912 1340085
SGTC_3128 9127691 49.47 µM -0.849453303934723 0.216758445228105 no 2679 0.197814551674393 3946 41316314
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.850497095487859 0.216466276755744 no 2680 0.197524387285423 3928 6710655
SGTC_2010 4012422 159 µM -0.851021202640985 0.216319659514739 no 2681 0.197378787443089 3903 952393
SGTC_1550 gossypolone 36.6 µM -0.852379351310505 0.215939989529046 no 2682 0.197001788439768 3905 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1667 st014849 34.6 µM -0.853890363247016 0.215518040742693 no 2683 0.196582869784653 3942 5348460
SGTC_1512 0259-0544 12.2 µM -0.856040448121749 0.214918456482651 no 2684 0.19598770334944 3858 18476
SGTC_77 0828-0286 12.516 µM -0.856562210469772 0.214773101238796 no 2685 0.195843438954399 3854 745345
SGTC_3004 9076122 71.4286 µM -0.858260842087576 0.214300283539965 no 2686 0.195374223315379 3946 44782551
SGTC_2572 astragaloside iv 100 µM -0.859979743508399 0.213822440611529 no 2687 0.194900104359147 3989 45006101 An anti-inflammatory agent.
SGTC_1328 1441-0025 69.2 µM -0.862685977624756 0.213071384671495 no 2688 0.194155072067318 3867 4562601
SGTC_964 1287-0107 19.4 µM -0.86288964383083 0.213014923919471 no 2689 0.194099072583555 3953 51516812 YPR165W RHO1
SGTC_2866 9034245 58.44 µM -0.863306895338967 0.212899279888377 no 2690 0.193984377021633 3899 6462273
SGTC_1160 4092-0570 10.5 µM -0.863516236311004 0.212841273451105 no 2691 0.193926848199995 3911 4994975
SGTC_2986 9022445 71.43 µM -0.863990402423148 0.212709920545698 no 2692 0.193796581449643 3921 6459286
SGTC_1815 st051655 58.2 µM -0.865244190201405 0.212362825940015 no 2693 0.19345238781626 3857 5984156
SGTC_3277 9138724 49.47 µM -0.865599097596939 0.212264634645218 no 2694 0.193355025323449 3860 15943418
SGTC_1794 st048918 76.9 µM -0.866075254247151 0.212132939330772 no 2695 0.193224447244497 3816 672303
SGTC_126 0417-1624 672.48 µM -0.867508292308429 0.211736878291876 no 2696 0.19283178514495 3982 41912 YDL195W SEC31
SGTC_1633 st005664 67.9 µM -0.868067172562423 0.211582533125579 no 2697 0.192678780401352 3943 2063822
SGTC_2402 5553605 200 µM -0.868484446556344 0.211467338118377 no 2698 0.192564591616057 3993 6758546
SGTC_2944 9067346 25.62 µM -0.869974353449636 0.211056325828384 no 2699 0.192157209958935 3873 6473075
SGTC_69 0096-0274 206.684 µM -0.872421448304297 0.210382276517462 no 2700 0.191489251929244 4077 6741392
SGTC_3330 9141424 71.43 µM -0.875614022058356 0.209504788614226 no 2701 0.190619949959697 4016 27261020
SGTC_426 0988-0037 14.6 µM -0.875713368714483 0.209477517492688 no 2702 0.190592937902642 3941 5383008
SGTC_1945 st075991 56.6 µM -0.876119326792266 0.209366101807904 no 2703 0.190482583543075 3968 1084980
SGTC_2372 9071633 200 µM -0.876161045831012 0.20935465394368 no 2704 0.190471244995129 3991 21321366
SGTC_813 k007-0158 173 µM -0.877502000822793 0.20898688699905 no 2705 0.190107016279895 3947 6523916
SGTC_3080 9117754 49.47 µM -0.87782274752349 0.208898976242202 no 2706 0.190019958889445 3943 9550191
SGTC_2639 lactacystin 53 µM -0.878189719182302 0.208798422802544 no 2707 0.189920385135652 3985 3870 A proteasome inhibitor.
SGTC_556 4058-0063 51.5 µM -0.878370729722012 0.208748834839069 no 2708 0.189871281717419 3989 6615692
SGTC_2976 9009005 19.48 µM -0.88004119300999 0.208291537918079 no 2709 0.189418497276649 3961 2993148
SGTC_2516 gossypol 71.55 µM -0.880415696166189 0.208189097135888 no 2710 0.189317078257531 3977 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_550 4123-0385 25.7 µM -0.880861749259845 0.208067123539344 no 2711 0.189196326460584 3959 5731123
SGTC_624 k048-0052 28 µM -0.885528326177637 0.206793575172118 no 2712 0.187935874521155 3934 6835531
SGTC_1153 4055-0057 267 µM -0.886597653353137 0.206502397937603 no 2713 0.187647778864149 3992 882706
SGTC_1320 1313-0481 95.3 µM -0.886865427415022 0.206429521242903 no 2714 0.187575678533802 3953 6813365 YLR208W SEC13
SGTC_3203 9113543 49.47 µM -0.890462221215738 0.205452105029305 no 2715 0.186608872612136 4057 17018012
SGTC_1670 st016595 4.04 µM -0.892226982437548 0.204973544010091 no 2716 0.186135641198401 3958 597879
SGTC_681 1642-0006 26.6 µM -0.893437037977685 0.204645789209041 no 2717 0.185811587741159 3970 4446530
SGTC_1203 3992-3522 103 µM -0.894183067400889 0.204443875662012 no 2718 0.185611975179171 4098 5322312
SGTC_2879 9041815 71.43 µM -0.895989013163569 0.203955585993996 no 2719 0.185129315584711 3970 4942971
SGTC_235 0330-0087 5 mM -0.897741734196445 0.203482352308283 no 2720 0.184661627107271 3972 46494818 YHR062C RPP1
SGTC_3204 9114183 49.47 µM -0.898076416045217 0.203392062932624 no 2721 0.18457240565672 3978 17027248
SGTC_3093 9117344 49.47 µM -0.898425321440584 0.203297961828312 no 2722 0.184479420956465 4008 24824913
SGTC_2948 9070189 9.45 µM -0.899878814777856 0.20290622883085 no 2723 0.184092372705323 3907 6473636 YDL196W YDL196W
SGTC_524 r073-0010 27.8 µM -0.901890458219455 0.202364812451325 no 2724 0.183557530280486 3889 2772106
SGTC_1554 st069299 38.7 µM -0.902729270272174 0.20213930893919 no 2725 0.183334798875467 3927 24207999
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.903707469656729 0.201876522986037 no 2726 0.18307526862538 3956 641818 YHR062C RPP1
SGTC_2288 7946289 167.31 µM -0.908746045202084 0.200526190543711 no 2727 0.181742096416226 4033 1246052
SGTC_33 0986-0033 35.816 µM -0.90881910725365 0.200506649979357 no 2728 0.18172280948587 3887 2848082
SGTC_1655 st012546 55.1 µM -0.90914974243297 0.200418235361667 no 2729 0.181635544376974 3972 720985 YLR208W SEC13
SGTC_2463 5473429 200 µM -0.91044196746724 0.200072908242543 no 2730 0.181294736792277 3978 5399405
SGTC_606 k015-0008 38.6 µM -0.911697559522798 0.199737713572415 no 2731 0.180963974523408 4053 1970475
SGTC_427 1354-0053 47.3 µM -0.914737280308365 0.198927625503294 no 2732 0.180164784041145 4100 6813657
SGTC_1024 4507-0395 26 µM -0.915074409350717 0.198837902485652 no 2733 0.18007628418862 4075 4201836
SGTC_1291 0993-0025 5.79 µM -0.916446031693732 0.198473112572603 no 2734 0.179716500648344 3985 4353356
SGTC_1843 st055809 45.5 µM -0.917038607130886 0.198315639109755 no 2735 0.179561204891206 4056 16413835
SGTC_3116 9124943 49.47 µM -0.91775297949891 0.1981258991025 no 2736 0.179374102073536 3979 41905195 YPL160W CDC60
SGTC_2113 5491891 107.031 µM -0.918181898942562 0.198012029152528 no 2737 0.179261821767166 4003 789979
SGTC_3257 9139206 32.98 µM -0.918604377477351 0.197899907788193 no 2738 0.179151270747841 3996 4910041
SGTC_1216 1165-0504 9.65 µM -0.919012975362465 0.197791506692268 no 2739 0.179044392717575 4035 6304004
SGTC_187 1488-2104 32.728 µM -0.920673681154228 0.197351290504977 no 2740 0.17861041050796 3996 2852859
SGTC_2299 7976368 114.88 µM -0.922453529527913 0.196880150730873 no 2741 0.178146029587875 4040 2979718
SGTC_1380 2291-0730 164 µM -0.922565744355637 0.196850469427333 no 2742 0.178116777101032 4039 2999191
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.922587401852685 0.196844741238347 no 2743 0.178111131710491 3967 688761
SGTC_2583 asiatic acid 100 µM -0.922709552517148 0.19681243551265 no 2744 0.178079293199393 4009 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3151 9099821 49.47 µM -0.923005389970303 0.196734207379753 no 2745 0.178002198180793 3977 17174189
SGTC_1868 st057644 42.7 µM -0.926437253710372 0.195828098561298 no 2746 0.177109395681329 4012 688665
SGTC_2261 9010538 184.68 µM -0.927460545174269 0.195558411696683 no 2747 0.176843733909324 4013 6457250
SGTC_1732 st034308 51.822 µM -0.927764891073722 0.195478245344089 no 2748 0.176764769781548 3869 830119
SGTC_838 0109-0203 71.4 µM -0.928926536400122 0.195172445215403 no 2749 0.176463579797798 4010 759422
SGTC_343 4130-2827 29.8 µM -0.929013060834527 0.195149679521866 no 2750 0.176441158845859 4036 1118244
SGTC_1612 st002233 45.4 µM -0.932392237020302 0.19426183754513 no 2751 0.175566927603928 4001 1035021
SGTC_2650 prasterone 100 µM -0.935085433069437 0.193555993919466 no 2752 0.174872136513041 3988 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1071 trifluoperazine 6.31 µM -0.935960577127456 0.193326969803652 no 2753 0.174646742886087 4108 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.936319000712017 0.19323321854799 no 2754 0.174554484046722 4009 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.936634861010492 0.193150623386596 no 2755 0.174473206730231 4118 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_543 3844-1095 191 µM -0.938378543617434 0.192695051118582 no 2756 0.174024954252745 4026 4230703
SGTC_2536 dehydroabietamide 32.04 µM -0.941163155500321 0.191968878031731 no 2757 0.173310627433939 4103 3983547
SGTC_2915 7971052 15.16 µM -0.942388314562567 0.191649911446411 no 2758 0.172996933852721 3927 5741558
SGTC_2158 5657123 3.6195 µM -0.943007466439942 0.191488840605009 no 2759 0.172838541941829 3950 2858827
SGTC_319 1348-1596 45.5 µM -0.943134704609434 0.191455750183923 no 2760 0.172806003226832 4130 5380505
SGTC_1220 1838-0075 193 µM -0.943515990616676 0.191356611342466 no 2761 0.172708520044025 3941 5529645
SGTC_2921 7974240 10.71 µM -0.943635157778719 0.191325632934542 no 2762 0.172678059833314 4126 2979074 YDR527W RBA50
SGTC_1934 st074720 32.6 µM -0.94586274347305 0.190747121019442 no 2763 0.172109299132668 3977 17250992
SGTC_292 k038-0015 474 µM -0.947116565820016 0.190421971568162 no 2764 0.171789692115781 4027 46368540
SGTC_2670 beta-carotene 100 µM -0.949322164415979 0.189850827855567 no 2765 0.171228392022977 3958 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2128 5255449 168.493 µM -0.951401500603298 0.189313345716079 no 2766 0.170700299435156 4021 736008
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.953472701454315 0.188778898690619 no 2767 0.17017531055915 3998 756377
SGTC_826 1683-5028 118 µM -0.953561767311687 0.188755937251456 no 2768 0.170152758193322 4082 722377
SGTC_3045 9092950 49.47 µM -0.959517320709606 0.187224485779373 no 2769 0.168649099119862 3992 44120432
SGTC_942 3253-1115 227 µM -0.959571780989089 0.187210517038642 no 2770 0.16863538850674 4105 46497897
SGTC_2453 5731132 22.18 µM -0.960731385908948 0.186913238185811 no 2771 0.168343622956222 4085 1362040
SGTC_1561 5-methoxyflavone 52.9 µM -0.961277460986341 0.186773346407174 no 2772 0.168206338762277 3957 94525
SGTC_2679 rapamycin 1 nM -0.961859064542499 0.186624424343083 no 2773 0.168060201878236 3987 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_178 4092-0806 87.505 µM -0.963231250481997 0.186273361752303 no 2774 0.167715742835484 3956 2169044
SGTC_1263 0774-1208 64.8 µM -0.963356125487567 0.186241433826198 no 2775 0.167684418121076 4088 906585
SGTC_3308 9128332 17.569 µM -0.967480662796807 0.185188782398153 no 2776 0.166651901723886 4073 17332805 YDL196W YDL196W
SGTC_620 0109-0052 432 µM -0.968019150215201 0.185051624556598 no 2777 0.166517402872731 4045 493037
SGTC_1149 3909-7961 23.3 µM -0.969531085965826 0.184666857684857 no 2778 0.166140138985359 4092 735261
SGTC_3283 9109332 35.8195 µM -0.970940105852232 0.184308729619821 no 2779 0.165789052520485 3890 17027281
SGTC_165 k038-0023 64.381 µM -0.972388818690914 0.183940963787381 no 2780 0.165428576191839 4066 46368543
SGTC_442 cape 100 µM -0.97279843115792 0.18383706373807 no 2781 0.165326746289504 4024 5281787
SGTC_1867 st057372 64 µM -0.973898123124607 0.183558302764298 no 2782 0.165053562874583 4022 688837
SGTC_1314 1222-0010 41.1 µM -0.974049871786851 0.183519856682726 no 2783 0.165015888716129 4070 3526027
SGTC_1803 st050068 52.4 µM -0.97489797817993 0.183305078230651 no 2784 0.164805434560481 4128 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1719 st032227 49.2 µM -0.975427737234786 0.183170999119142 no 2785 0.164674065258459 4070 3125804
SGTC_1100 amiodarone 5.07 µM -0.97570430435582 0.183101025807574 no 2786 0.164605509289273 4158 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_203 k066-0004 30.888 µM -0.977052961795533 0.182760045525163 no 2787 0.164271466621316 4142 6795412
SGTC_27 0485-0001 32.618 µM -0.977259875591407 0.182707766726118 no 2788 0.164220256028843 3987 2054479
SGTC_2744 captopril 92.04 µM -0.980169053297366 0.181973723213379 no 2789 0.163501338825749 4097 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_922 1866-0035 480 µM -0.98105310064935 0.18175102629637 no 2790 0.16328327821607 4008 3156169
SGTC_1886 st057356 49.9 µM -0.98172199504838 0.181582641076926 no 2791 0.163118413224632 4021 24207747
SGTC_1283 0922-0125 16.4 µM -0.983315569676827 0.181181873502668 no 2792 0.162726074778578 4074 3360884
SGTC_1607 st000305 50.6 µM -0.983536834040564 0.181126271634769 no 2793 0.162671648008921 4090 5457690
SGTC_3177 9107506 49.47 µM -0.984225169780876 0.180953367029996 no 2794 0.162502406411137 4030 8897194
SGTC_825 1988-2224 89.6 µM -0.984374712317389 0.180915816784586 no 2795 0.162465653436778 4054 1180859
SGTC_1053 3366-3204 134 µM -0.990448056458726 0.179394923702769 no 2796 0.160977583121659 4104 3632071 YPR165W RHO1
SGTC_879 0831-1030 162 µM -0.992183886742332 0.17896171664707 no 2797 0.160553915636523 4105 1549252
SGTC_1388 3346-4487 254 µM -0.992651696420334 0.178845079200291 no 2798 0.160439861128759 4136 3345614
SGTC_1761 st044296 37 µM -0.993559186549473 0.178618954149596 no 2799 0.160218761160021 4068 1826700
SGTC_1931 st074438 57.1 µM -0.99584321711673 0.178050625075007 no 2800 0.159663164178559 4045 2787313
SGTC_1121 fusaric acid 630.51 nM -0.995988595492587 0.178014489606065 no 2801 0.159627843200989 4048 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2461 5755302 26.15 µM -0.99634485910043 0.177925955737426 no 2802 0.159541307390637 4141 2788904
SGTC_2360 9040895 200 µM -0.997165721980272 0.177722071589781 no 2803 0.15934203812745 4113 4914414
SGTC_1569 carminic acid 40.6 µM -0.998181658685297 0.177469939620546 no 2804 0.159095639318362 4189 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1998 st075797 76.8 µM -0.998425209960122 0.177409529402181 no 2805 0.159036607057551 4063 24208315
SGTC_1330 1469-0054 61.8 µM -0.998778690037304 0.177321875648923 no 2806 0.158950955649476 4088 7102664
SGTC_2302 7771753 200 µM -0.999402576774249 0.177167234902362 no 2807 0.158799856043665 4089 2203047
SGTC_884 0851-0618 334 µM -0.999522978276137 0.177137401188232 no 2808 0.158770706753776 4107 9642473
SGTC_1356 1502-0781 85.8 µM -0.999639548503046 0.177108519831208 no 2809 0.158742488360386 4074 567702
SGTC_3261 9137475 49.47 µM -1.00040246265366 0.176919574209505 no 2810 0.158557889348306 4019 17027690
SGTC_3139 9095020 49.47 µM -1.00040450985419 0.176919067365076 no 2811 0.158557394185582 3781 25236292
SGTC_2746 daunorubicin 9.88 µM -1.00099122063902 0.176773847750094 no 2812 0.158415526425596 4012 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1759 st043059 70 µM -1.00227002870443 0.176457585000151 no 2813 0.158106596881871 4096 669426
SGTC_626 0214-0009 33 µM -1.00235935657033 0.176435506656928 no 2814 0.158085032184805 4161 3437874
SGTC_83 0170-0301 39.027 µM -1.00236826053467 0.176433306042113 no 2815 0.158082882778914 4068 3089716
SGTC_2441 5730946 39.09 µM -1.00313329566106 0.176244292448087 no 2816 0.157898275887114 4147 1774275
SGTC_2186 6124449 200 µM -1.00469336139714 0.175859251687978 no 2817 0.157522262886136 4096 3834182 YLR033W RSC58
SGTC_2898 9056270 58.44 µM -1.00820975138974 0.17499332493435 no 2818 0.156676888763688 4054 19154699
SGTC_3065 9113888 49.47 µM -1.00875779096718 0.174858611820575 no 2819 0.156545404232048 4170 16648368
SGTC_3149 9097855 49.47 µM -1.01077746505416 0.17436272597183 no 2820 0.156061475536246 4099 25236625 YMR079W SEC14
SGTC_2843 9000894 45.46 µM -1.01401876073128 0.173568767742454 no 2821 0.155286900191113 4020 2242070
SGTC_2995 9067767 71.4286 µM -1.01796850061609 0.17260439051417 no 2822 0.154346462907197 4128 11673567
SGTC_732 3970-1727 52.7 µM -1.02244796152241 0.17151481834866 no 2823 0.153284465172958 4179 1275699
SGTC_497 capsazepine 133 µM -1.02277856473089 0.171434577840361 no 2824 0.153206277545811 4080 2733484 A calcium channel blocker.
SGTC_253 dyclonine 31.25 µM -1.0233950619166 0.171285012271881 no 2825 0.153060546625255 4207 3180 An oral anasthetic.
SGTC_939 1165-0479 45.3 µM -1.0237135255027 0.171207783962368 no 2826 0.152985302494044 4106 1377347
SGTC_2065 5221596 34.26 µM -1.02687961036657 0.170441210851806 no 2827 0.152238578219266 4120 788581
SGTC_3018 9082602 49.47 µM -1.02707804723613 0.170393238590357 no 2828 0.152191857407124 4074 17332089
SGTC_194 1486-1323 56.904 µM -1.02863812835252 0.17001638911593 no 2829 0.151824877005603 4181 5178754
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.03296709311757 0.168973495070227 no 2830 0.150809649294106 4112 676296 Flavone; oxidizing agent.
SGTC_3343 9148379 18.9835 µM -1.03368600132107 0.168800701075322 no 2831 0.150641489737772 4161 1955036
SGTC_716 1683-5115 658 µM -1.03394466143019 0.168738558316842 no 2832 0.150581017203852 4059 723597
SGTC_1745 st081495 74 µM -1.03400939083573 0.168723009460653 no 2833 0.150565886548973 4021 13842402 YBL026W LSM2
SGTC_629 3448-6466 76.7 µM -1.03429572770642 0.168654238617363 no 2834 0.150498966761764 4123 573744
SGTC_2640 pentamidine 10.38 µM -1.03431504469053 0.168649599817256 no 2835 0.150494452903108 4118 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2595 hexamethylquercetagetin 100 µM -1.03803207137552 0.167758515574225 no 2836 0.149627562085625 4110 386331
SGTC_1777 st045864 34.765 µM -1.03974129513497 0.167349782130028 no 2837 0.149230054780851 4116 4691462
SGTC_1222 0366-0074 1.18 µM -1.04114620252348 0.167014302028685 no 2838 0.148903849610506 4151 286520
SGTC_2405 ticlatone 3.52 µM -1.04267610921749 0.166649466791504 no 2839 0.148549163190567 3973 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1606 st000094 49.2 µM -1.04401054172677 0.16633166635308 no 2840 0.148240256203227 4175 1242210
SGTC_1973 st070275 50.2 µM -1.0451307845794 0.166065178419577 no 2841 0.147981263908832 4088 17118334
SGTC_232 clozapine 119 µM -1.0453547295652 0.166011938577523 no 2842 0.147929525745456 4088 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_866 0495-0101 262 µM -1.04601315833768 0.165855470080177 no 2843 0.147777478642276 4118 635694
SGTC_2270 7924575 90.91 µM -1.04681727617618 0.165664509487365 no 2844 0.147591930404597 4133 1262135
SGTC_1997 st073024 93.8 µM -1.05006240899585 0.164895305904257 no 2845 0.146844710132398 4147 686268
SGTC_2220 6782180 200 µM -1.05038316796795 0.164819401252956 no 2846 0.146770990622113 4057 833803
SGTC_3142 9086498 49.47 µM -1.05043466507636 0.164807217046132 no 2847 0.146759157439396 4048 25236367
SGTC_1531 st059297 52.4 µM -1.05102018078035 0.164668725162459 no 2848 0.146624660638472 4145 7566702
SGTC_2437 5741531 144.16 µM -1.05362711903483 0.16405302226114 no 2849 0.146026834069006 4174 2262990
SGTC_1966 st070145 16.1 µM -1.05512454761083 0.16370003791201 no 2850 0.145684183248835 4121 3748532
SGTC_179 1273-0063 6.77 µM -1.0578350350052 0.163062357759132 no 2851 0.145065328571135 4121 3108139
SGTC_1082 camptothecin 424.86 nM -1.06062769089044 0.162407037401223 no 2852 0.144429566546311 4048 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1771 st048882 4.1505 µM -1.06123241967164 0.162265358755473 no 2853 0.144292144717241 4174 4580403
SGTC_2919 7978188 46.38 µM -1.06273700739934 0.161913206266914 no 2854 0.143950616631631 4171 2980291
SGTC_2382 9035899 200 µM -1.06349920679789 0.161735001749597 no 2855 0.143777812353379 4145 6462679
SGTC_3310 9130229 44.1445 µM -1.06420327762705 0.161570501483134 no 2856 0.143618311272728 4196 7761258
SGTC_3246 9135460 32.98 µM -1.0646568496442 0.161464585958986 no 2857 0.143515621775244 4126 41446951
SGTC_809 3998-0021 90 µM -1.06567485291315 0.161227032575926 no 2858 0.143285324555256 4114 715485
SGTC_1424 4048-1941 275 µM -1.06630732661632 0.16107955828555 no 2859 0.143142369309996 4228 X1424
SGTC_1189 1431-2119 7.28 µM -1.0693997088458 0.160359773363406 no 2860 0.142444799234051 4157 3107275
SGTC_844 0330-0132 15.3 µM -1.07031637865719 0.160146813185142 no 2861 0.142238462247854 4209 2828079
SGTC_367 0335-0881 7.1 µM -1.07089374675446 0.160012774322689 no 2862 0.142108603944474 4129 23828853
SGTC_3230 9131665 49.47 µM -1.07257074238792 0.159623867607748 no 2863 0.141731878883476 4129 15943720
SGTC_373 0844-0104 25.9 µM -1.07272616657952 0.15958785502693 no 2864 0.141696998234237 4182 5375804
SGTC_1296 1068-0102 11.9 µM -1.07393893213804 0.159307033679366 no 2865 0.141425026345281 4176 767053
SGTC_1270 0831-1170 17.3 µM -1.07438252737763 0.159204398071894 no 2866 0.141325635167453 4193 6764716
SGTC_3155 9099265 49.47 µM -1.07523089280529 0.15900823053972 no 2867 0.141135683774811 4183 25236499
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.07609005517659 0.158809727911372 no 2868 0.140943491428987 4156 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2504 purpurogallin 52.29 µM -1.07614543349113 0.158796938767223 no 2869 0.14093110953987 4065 5281571 An antioxidant.
SGTC_3250 9135583 49.47 µM -1.07846971638546 0.158260774490227 no 2870 0.140412094669182 4210 7699353
SGTC_1903 st060211 78.3 µM -1.08317042939409 0.157180051490157 no 2871 0.139366391228613 4210 688960
SGTC_2025 5147754 141 µM -1.08490665140379 0.156782113440973 no 2872 0.138981500880712 4149 315777 YLR208W SEC13
SGTC_1644 st010134 20.9 µM -1.08518105528614 0.156719281435357 no 2873 0.138920736581666 4159 3818134
SGTC_362 0310-0100 9.03 µM -1.08527285184417 0.156698265892441 no 2874 0.138900413088836 4251 790235
SGTC_1410 3909-8106 77.9 µM -1.08643077428752 0.156433334955221 no 2875 0.138644226234478 4232 1039210
SGTC_2219 9098279 200 µM -1.08711761376317 0.156276326558818 no 2876 0.138492417257367 4112 902349
SGTC_865 0488-0499 301 µM -1.09560249800087 0.154345285042695 no 2877 0.136626384028939 4159 9634651
SGTC_1394 3474-0001 65.7 µM -1.09592747411151 0.154271640066656 no 2878 0.13655525733637 4194 5017666 YIL048W NEO1
SGTC_2148 5546263 113.568 µM -1.09814208647015 0.153770391030855 no 2879 0.136071225097579 4174 792097
SGTC_120 rhodamine 6G 52.259 µM -1.10351609768961 0.152558539541196 no 2880 0.134901552387588 4201 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2140 5586273 200 µM -1.10390337384234 0.152471453362067 no 2881 0.134817527596337 4161 854421
SGTC_1078 idebenone 36.1 µM -1.11146515980089 0.150777657599743 no 2882 0.133184089279084 4246 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_438 sphingosine 6.67 µM -1.11240273817111 0.150568521849088 no 2883 0.13298251392619 4158 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_887 0885-0007 9.62 µM -1.11302257423506 0.150430367671425 no 2884 0.132849367193544 4274 5719458
SGTC_1924 st058459 75.1 µM -1.11309819317811 0.150413518879186 no 2885 0.132833129804004 4155 688683
SGTC_2861 9024595 19.48 µM -1.11367196688502 0.150285716295551 no 2886 0.132709969919952 4104 16482810
SGTC_2277 7947813 106.88 µM -1.11368048439015 0.150283819648333 no 2887 0.132708142239644 4261 1246798
SGTC_1360 1598-0022 39.8 µM -1.11428980183971 0.150148180430145 no 2888 0.132577440305805 4245 761525
SGTC_616 4092-0450 108 µM -1.11557040645528 0.14986337307203 no 2889 0.132303032726694 4204 787165
SGTC_247 mechlorethamine 29.705 µM -1.11621461427999 0.149720237108399 no 2890 0.132165140170043 4110 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1042 0350-0096 82 µM -1.1188115983041 0.149144140716414 no 2891 0.131610261306895 4190 3122515
SGTC_408 cantharidin 100 µM -1.11950967114001 0.148989538021178 no 2892 0.131461383682526 4177 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2046 4110841 106 µM -1.12020248114978 0.148836206781903 no 2893 0.131313743448737 4199 44119630 YMR134W ERG29
SGTC_3105 9121040 49.47 µM -1.12036989635222 0.148799170630495 no 2894 0.131278083867692 4096 41448907
SGTC_1332 1480-0653 17.5 µM -1.12037639378082 0.148797733371762 no 2895 0.131276700044672 4215 5749438
SGTC_3326 9140064 16.379 µM -1.12382381573532 0.148036457323515 no 2896 0.130543888004437 4130 1868434
SGTC_3183 9108214 49.47 µM -1.12524392922836 0.147723620538532 no 2897 0.130242841321382 4152 4974831
SGTC_254 nsc-64875 3.808 µM -1.12540099607066 0.147689047496748 no 2898 0.130209574597769 4216 56993
SGTC_1303 1160-0052 261 µM -1.12626281791353 0.147499442527674 no 2899 0.130027145552538 4157 3562476
SGTC_1855 st056195 39.6 µM -1.12808311718537 0.147099504103343 no 2900 0.129642409217205 4162 4028379
SGTC_2125 5246583 200 µM -1.12923817834246 0.146846102722934 no 2901 0.129398686146519 4246 835267
SGTC_3136 9095672 49.47 µM -1.12934977135407 0.146821636576372 no 2902 0.129375156352374 3954 17217380
SGTC_122 0236-0016 402.397 µM -1.12943474505629 0.146803008399203 no 2903 0.129357241325454 4216 6808838
SGTC_115 0527-0192 112.043 µM -1.13004627245921 0.146668994385258 no 2904 0.129228363556295 4207 4233931
SGTC_3021 9087658 49.47 µM -1.13109087069404 0.14644026440634 no 2905 0.129008423187622 4221 25237042
SGTC_613 3914-0030 117 µM -1.13224007643485 0.146188905867097 no 2906 0.12876675771319 3928 1145395
SGTC_2782 7736369 71.43 µM -1.13345152425623 0.145924247429908 no 2907 0.128512343639679 4250 2950836 YOL077C BRX1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.13388834422029 0.145828896767296 no 2908 0.128420693468888 4236 77254
SGTC_1702 st027038 51 µM -1.1341284413634 0.145776505320643 no 2909 0.128370337480141 4259 5521182
SGTC_3226 9131256 49.47 µM -1.1346250013437 0.14566819142486 no 2910 0.128266236594914 4177 17178073
SGTC_2768 sulfasalazine 50.2 µM -1.13613069160251 0.145340088271 no 2911 0.12795093589615 4204 5384001 An antioxidant and salicylic acid derivative.
SGTC_1662 st014054 52 µM -1.13638155099097 0.145285472156096 no 2912 0.127898456792861 4264 2838777
SGTC_2341 7987486 176.74 µM -1.13706747513256 0.145136205965325 no 2913 0.127755039687676 4255 1258686
SGTC_221 trifluoperazine 10.304 µM -1.13840374191326 0.14484571305602 no 2914 0.127475966142026 4199 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1685 st024049 53.0905 µM -1.14017801060873 0.144460607711881 no 2915 0.127106073328692 4244 1941139
SGTC_1348 1493-0373 93.8 µM -1.14031790624065 0.144430272711251 no 2916 0.127076940215956 4246 3010129
SGTC_2149 5554786 194.827 µM -1.14048102706533 0.144394906975664 no 2917 0.127042976350549 4260 745063 YPR165W RHO1
SGTC_1279 0874-0590 65.2 µM -1.14290221093566 0.143870663563741 no 2918 0.126539597249315 4290 3523074
SGTC_1090 efavirenz 20.7 µM -1.14498688546818 0.143420312287724 no 2919 0.126107295006164 4257 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2886 9058944 51.95 µM -1.14555528898838 0.14329768565248 no 2920 0.125989603113709 4099 4949929
SGTC_1391 3442-0225 151 µM -1.15103629516116 0.142118854089761 no 2921 0.124858652031039 4213 5227075
SGTC_2692 st077426 47.7 µM -1.15145742462058 0.142028551663924 no 2922 0.124772050534717 4261 25238571
SGTC_3168 9103419 49.47 µM -1.1516488609132 0.141987514989391 no 2923 0.124732697258701 4252 16649256
SGTC_2794 7785382 27.27 µM -1.15383646647313 0.141519145357737 no 2924 0.124283610281984 4230 2205081
SGTC_736 0958-0254 92.6 µM -1.15403448135703 0.141476801801946 no 2925 0.12424301628787 4329 6812352
SGTC_1014 4130-3005 69.3 µM -1.15487304496599 0.141297578305378 no 2926 0.124071209560024 4256 743608
SGTC_1085 doxorubicin 7.67 µM -1.15658586854746 0.140931980449664 no 2927 0.123720799270329 4263 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3260 9137109 49.47 µM -1.15809208780124 0.140611012454657 no 2928 0.123413229262742 4196 17478346
SGTC_2238 6671620 73.2395 µM -1.15954558331264 0.14030175038673 no 2929 0.123116933669451 4165 729941
SGTC_562 3772-2733 112 µM -1.15957663168985 0.140295149227596 no 2930 0.123110609890093 4231 2876874 YIL048W NEO1
SGTC_2812 7970281 58.44 µM -1.17616545711738 0.136798356545266 no 2931 0.11976438252034 4307 2233435
SGTC_2648 atorvastatin 78.68 µM -1.17649357233567 0.136729798681544 no 2932 0.119698849723865 4263 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1155 4088-0394 48.2 µM -1.17740625312836 0.136539222625539 no 2933 0.119516697610371 4242 2326248
SGTC_2935 9038016 29.96 µM -1.18176874610282 0.135630804422236 no 2934 0.118648736075832 4248 6463195
SGTC_478 N-arachidonylglycine 10 µM -1.18183418351759 0.135617209738438 no 2935 0.118635750641387 4249 5283389
SGTC_291 SEC14.278 35.5 µM -1.18242072587271 0.135495396702758 no 2936 0.118519401711174 4307 1068044
SGTC_1888 azatryptophan 97.5 µM -1.1869783309562 0.134551428662124 no 2937 0.117618083930415 4321 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3199 9111318 49.47 µM -1.18800335945178 0.134339748777106 no 2938 0.117416043076758 4207 8548020
SGTC_2235 salicylic acid 500 µM -1.1888318784948 0.13416881750861 no 2939 0.117252915417226 4302 338 A COX inhibitor and kinase inhibitor.
SGTC_1613 st002381 52.1 µM -1.18903091630387 0.13412777640306 no 2940 0.117213750658293 4256 551167
SGTC_262 fenpropimorph 62.5 µM -1.18945093604725 0.134041197672106 no 2941 0.117131133598205 4271 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2266 7929956 200 µM -1.19047844767836 0.133829558441816 no 2942 0.116929198011816 4215 2967153
SGTC_2089 5281248 129.67 µM -1.19081072861678 0.133761166851182 no 2943 0.116863948079284 4265 2737878
SGTC_2839 9003951 25.97 µM -1.19244930792834 0.133424258319761 no 2944 0.116542558080389 4331 2990634
SGTC_2813 7971799 71.43 µM -1.19259010564067 0.133395336138548 no 2945 0.116514971373078 4282 2234054
SGTC_2707 st078556 66.6 µM -1.19468696366746 0.132965117128496 no 2946 0.116104678842495 4219 17250899
SGTC_1157 4092-0394 27.6 µM -1.19610070937457 0.132675594133141 no 2947 0.115828630423571 4352 3659885
SGTC_1413 3910-0535 34.4 µM -1.19646550612462 0.132600957420988 no 2948 0.115757475808843 4307 2876951
SGTC_2910 7948405 25.97 µM -1.19973065945076 0.131934201392699 no 2949 0.115121980852949 4200 2971328
SGTC_2144 5628481 200 µM -1.20160296940001 0.131552913913005 no 2950 0.114758695236819 4271 2818399
SGTC_1912 st060209 90.8 µM -1.20506700995743 0.130849484558 no 2951 0.114088717073376 4284 688787
SGTC_1988 st071872 53.4 µM -1.20598371160239 0.130663769277769 no 2952 0.113911885477432 4319 16414116
SGTC_1251 0490-5699 265 µM -1.20677691408647 0.130503220912008 no 2953 0.113759034525304 4331 3883818
SGTC_402 epigallocatechin gallate 10 µM -1.20755354452389 0.130346159043189 no 2954 0.113609518714881 4237 65064 An antioxidant.
SGTC_2351 9026858 72.31 µM -1.21824767951613 0.128196722360941 no 2955 0.111564932919193 4199 1409300
SGTC_1944 st076371 56.9 µM -1.21844308096018 0.128157678565509 no 2956 0.111527821123415 4266 24208455
SGTC_3297 9117502 71.43 µM -1.22025468952134 0.127796088405437 no 2957 0.111184170291352 4325 7453720
SGTC_1776 st049249 45.9 µM -1.2212393851338 0.127599844628177 no 2958 0.110997698049163 4319 1822314
SGTC_2425 5628681 7.85 µM -1.22158772228167 0.127530473370188 no 2959 0.110931786955963 4370 5714958
SGTC_1169 aniline yellow 25.8 µM -1.22175402655589 0.127497363164788 no 2960 0.110900329353289 4213 6051 A DNA damaging agent.
SGTC_2204 7233102 200 µM -1.22191091129204 0.127466133813866 no 2961 0.110870659379605 4222 2172480
SGTC_227 fluconazole 33.516 µM -1.22330375559535 0.127189108580931 no 2962 0.110607494604409 4301 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1971 st069429 63.5 µM -1.22377237066506 0.1270959991567 no 2963 0.110519054948976 4300 1246522 YGL099W LSG1
SGTC_900 1112-0045 141 µM -1.22434756486022 0.126981778312124 no 2964 0.110410570396882 4177 56211 YIL048W NEO1
SGTC_2570 licareol 100 µM -1.22484171027673 0.12688370903279 no 2965 0.110317433045708 4285 443158
SGTC_2303 7774051 200 µM -1.22503866709273 0.126844635212466 no 2966 0.110280326004882 4330 2953184
SGTC_2097 5376186 200 µM -1.22581368787552 0.126690961921473 no 2967 0.110134397520804 4294 742755
SGTC_1522 st012842 45.6 µM -1.22757092064854 0.126343013258271 no 2968 0.109804041775561 4148 3491067 YOR116C RPO31
SGTC_40 0327-0103 19.753 µM -1.22918126020594 0.126024736060582 no 2969 0.109501926711096 4157 409036
SGTC_1629 st005085 44.9 µM -1.23432453204561 0.125011934656768 no 2970 0.108540999042868 4253 24207091
SGTC_1559 coumarin 343 70.1 µM -1.23550688218611 0.124779914913828 no 2971 0.10832095835441 4335 108770 A hepatotoxic, DNA x-linker.
SGTC_1297 1068-0111 14.1 µM -1.24137751905402 0.123632341263319 no 2972 0.107233159979098 4312 767057
SGTC_2239 6685329 187.64 µM -1.24193520960309 0.1235237113033 no 2973 0.107130233962233 4345 805680
SGTC_2964 9083345 53.42 µM -1.24218233267532 0.123475596725169 no 2974 0.107084648313175 4294 17741579
SGTC_2708 st078559 56 µM -1.24231279185929 0.123450201767003 no 2975 0.107060588754311 4264 17250902
SGTC_1135 dihydrocapsaicin 536.708 nM -1.2430109554471 0.123314360635635 no 2976 0.106931898208403 4225 107982 A Capsaicinoid.
SGTC_1510 1123-0200 71.5 µM -1.24343162997721 0.123232560910888 no 2977 0.106854410344713 4338 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_640 3381-0960 37.1 µM -1.24571217672239 0.122789772798112 no 2978 0.106435040813141 4374 1745025
SGTC_2032 5185112 25.99 µM -1.24795641178644 0.122355125373788 no 2979 0.106023510073845 4205 5718189
SGTC_2926 9010726 65.15 µM -1.24912285000541 0.122129644927757 no 2980 0.105810072153143 4334 2994293
SGTC_3160 9100216 49.47 µM -1.25228299821833 0.121520233271729 no 2981 0.105233380914835 4300 17191039
SGTC_902 1120-0002 2.07 µM -1.25488427017014 0.121020203231386 no 2982 0.104760387493232 4317 3280475
SGTC_2506 ethyl hematommate 54.16 µM -1.2575915351039 0.120501337792484 no 2983 0.104269758138669 4381 3940691 An allergen.
SGTC_3129 9127257 49.47 µM -1.25816599285642 0.120391440897178 no 2984 0.104165865448709 4284 837894
SGTC_2867 9039098 71.43 µM -1.25871329052712 0.120286805558048 no 2985 0.104066954577843 4313 6463460
SGTC_945 3381-0768 11.3 µM -1.25909463869055 0.120213935229667 no 2986 0.103998075350204 4348 1126236 YIL048W NEO1
SGTC_2130 NSC 7 2.4545 µM -1.26053158588903 0.119939634043785 no 2987 0.103738830464538 4410 21448
SGTC_1005 4092-0690 4.4 µM -1.26200371204414 0.119659075339502 no 2988 0.103473725330961 4353 1529343
SGTC_1035 k081-0041 55.2 µM -1.26238339138026 0.119586790961981 no 2989 0.103405431309207 4354 731709
SGTC_290 2043-6722 48.1 µM -1.26297677105293 0.119473883430363 no 2990 0.103298763925075 4348 773758 YLR208W SEC13
SGTC_3007 9078383 71.4286 µM -1.26330918781776 0.119410664467848 no 2991 0.103239042796294 4322 6496995
SGTC_704 1310-0270 142 µM -1.26517231364123 0.119056772404095 no 2992 0.102904782465849 4345 5718033
SGTC_61 0978-8327 98.565 µM -1.26592740359134 0.118913557669337 no 2993 0.102769537169437 4248 6150059 YHR072W ERG7
SGTC_167 3672-0051 66.205 µM -1.2700878520406 0.118126644856004 no 2994 0.102026669161978 4251 3237971
SGTC_166 k072-0058 166.424 µM -1.2701708850864 0.118110977446878 no 2995 0.102011883087395 4234 5846229
SGTC_696 1560-0013 611 µM -1.27936743569617 0.116384777937652 no 2996 0.100383847798931 4397 1650269
SGTC_977 1348-1378 135 µM -1.28229625311833 0.115838812972327 no 2997 0.0998693709282783 4347 X977
SGTC_1119 parthenolide 318.541 nM -1.28848558847095 0.114691038903743 no 2998 0.0987884911654106 4424 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2779 methotrexate 400 µM -1.28945129538378 0.114512686875505 no 2999 0.0986206191198468 4372 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3144 9087057 49.47 µM -1.29060614305478 0.114299662609065 no 3000 0.0984201423892421 4277 17249618
SGTC_1636 st007707 68.9 µM -1.29469000137305 0.113548614043913 no 3001 0.0977135952652552 4372 403051
SGTC_198 3454-2873 16.191 µM -1.29502148424626 0.113487806911234 no 3002 0.0976564091049544 4369 710957
SGTC_44 0929-0055 61.211 µM -1.29524951386707 0.113445990699705 no 3003 0.0976170845542329 4241 1379590
SGTC_1401 3807-4679 7.6 µM -1.29609572395404 0.113290908225931 no 3004 0.0974712539974295 4273 3291456
SGTC_1 0258-0098 57.368 µM -1.29933390740094 0.112698852471989 no 3005 0.0969146813635653 4293 6790032 YDR047W HEM12
SGTC_3049 9092223 49.47 µM -1.30013801243187 0.112552176373202 no 3006 0.0967768357111088 4349 8623917
SGTC_937 3122-0005 46.7 µM -1.3004842502939 0.112489061440636 no 3007 0.0967175254129807 4378 759535
SGTC_2975 9084847 53.72 µM -1.30135033936015 0.112331294715576 no 3008 0.0965692818917042 4371 27211724
SGTC_1407 3909-7909 12.3 µM -1.30142131519336 0.11231837277559 no 3009 0.0965571407676421 4387 4411780
SGTC_3125 9127534 49.47 µM -1.30173310363743 0.112261620802772 no 3010 0.0965038195278198 4257 1639235
SGTC_2198 6589944 200 µM -1.30199582544331 0.112213815888754 no 3011 0.0964589063328229 4369 5290268
SGTC_948 3448-0295 75.3 µM -1.30782404253465 0.111157051596656 no 3012 0.0954664987329094 4346 678569
SGTC_2359 9039622 200 µM -1.3087906851407 0.110982472532179 no 3013 0.0953026315479246 4323 6463596
SGTC_3265 9137266 49.47 µM -1.30992110557978 0.110778563841312 no 3014 0.0951112632204825 4328 17224265
SGTC_790 1575-0012 79.1 µM -1.31053434597392 0.110668058045824 no 3015 0.0950075665351745 4407 378741 YLR208W SEC13
SGTC_775 4577-0580 57.3 µM -1.31337566859618 0.110157083264267 no 3016 0.094528196088488 4409 2006902
SGTC_1754 st042065 16.137 µM -1.31585812996369 0.109712032088579 no 3017 0.0941108321097742 4139 1126236 YIL048W NEO1
SGTC_97 0535-0701 19.132 µM -1.3171501229371 0.109480917306958 no 3018 0.0938941543642507 4276 2832013 YGL099W LSG1
SGTC_3150 9097574 49.47 µM -1.31839016502405 0.109259424662088 no 3019 0.0936865357031569 4413 17217476
SGTC_3346 9158254 43.5805 µM -1.31907550854436 0.109137148855658 no 3020 0.093571935046311 4390 17639500
SGTC_2104 5389443 200 µM -1.32260368207212 0.10850922461741 no 3021 0.0929836045629587 4418 2244536
SGTC_465 cgp-37157 41 µM -1.3264926654104 0.107820101564244 no 3022 0.0923382815028667 4404 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1594 piperine 70.1 µM -1.32754361184676 0.107634417363366 no 3023 0.0921644616669863 4375 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_492 tmb-8 126 µM -1.33432514953562 0.10644177456842 no 3024 0.091048659413451 4400 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_3111 9122088 49.47 µM -1.3394330125721 0.105549795409423 no 3025 0.0902148741534562 4284 16876704
SGTC_511 blebbistatin 171 µM -1.33979017611593 0.10548762723739 no 3026 0.0901567851926763 4454 3476986 A myosin inhibitor.
SGTC_1193 1488-0126 41.5 µM -1.33993998327401 0.10546155956861 no 3027 0.0901324288789662 4363 1384710
SGTC_1300 1094-0077 113 µM -1.34196296507764 0.105110000394233 no 3028 0.08980400206741 4363 5532636
SGTC_2840 9008771 71.43 µM -1.34201597613945 0.105100799408189 no 3029 0.0897954078102988 4336 2992978
SGTC_2499 avocadenofuran 51.48 µM -1.3465749665778 0.104311687165159 no 3030 0.0890585805433456 4354 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_535 2293-4129 48.2 µM -1.35157060138793 0.103451936872654 no 3031 0.0882563601270861 4407 396118 YIL048W NEO1
SGTC_1354 1498-1681 81 µM -1.35225715344392 0.103334184223371 no 3032 0.0881465329549846 4383 5754243
SGTC_3215 9129942 49.47 µM -1.35823752243872 0.102312586144418 no 3033 0.0871941639309283 4392 17682944
SGTC_3271 9137798 49.47 µM -1.3583695103362 0.102290122423336 no 3034 0.0871732319646246 4391 6498326
SGTC_1994 st072947 40.9 µM -1.36380206989603 0.101368636304334 no 3035 0.0863149343351537 4455 5286565 YDL195W SEC31
SGTC_2809 7964133 12.99 µM -1.36430149831726 0.101284226351026 no 3036 0.0862363472694154 4393 1253665
SGTC_1022 4477-0945 21.3 µM -1.3645004091624 0.101250622073322 no 3037 0.0862050627559729 4353 4648966
SGTC_512 prima-1 270 µM -1.36454027275071 0.101243888439992 no 3038 0.0861987940689901 4414 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_758 0868-0029 16 µM -1.36463477996678 0.101227925878845 no 3039 0.0861839338451764 4394 762687
SGTC_2955 9076254 12.21 µM -1.36987150714234 0.100346290396683 no 3040 0.0853635077133244 4331 16459619
SGTC_1897 st060201 15 µM -1.37606214044404 0.0993113027182607 no 3041 0.084401197754466 4431 611878
SGTC_3334 9142812 21.919 µM -1.37660492128469 0.099220930843761 no 3042 0.0843172142743876 4423 45283678
SGTC_2430 5571206 200 µM -1.38162012996051 0.0983887525126987 no 3043 0.0835441849043431 4401 1731771
SGTC_19 0279-0214 38.434 µM -1.38408927346979 0.0979809278259333 no 3044 0.0831655604805039 4483 3566274 YBR002C RER2
SGTC_3060 1327-0027 12.5 µM -1.38483355857214 0.0978582387102525 no 3045 0.0830516834774636 4332 16000455 YPR107C YTH1
SGTC_1707 st032323 6.317 µM -1.38496702189426 0.0978362503199619 no 3046 0.0830312757472745 4253 3132057 YMR211W DML1
SGTC_1750 st081859 2.357 µM -1.38606460086828 0.0976555589940417 no 3047 0.0828635891773606 4347 5291695
SGTC_1520 flindersine 88 µM -1.38870144291571 0.0972224634248134 no 3048 0.0824617776280153 4459 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2017 5132927 60.65 µM -1.38889917444107 0.0971900433499315 no 3049 0.0824317058087057 4418 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1977 st070720 65.3 µM -1.39089158140699 0.0968638107833295 no 3050 0.0821291530238693 4457 682188
SGTC_2258 7960471 200 µM -1.39218930166317 0.0966517576050629 no 3051 0.0819325407793405 4425 2974708
SGTC_2305 7443522 69.23 µM -1.397152320188 0.0958439241399685 no 3052 0.0811838855949745 4324 5415886
SGTC_714 4296-0578 26.1 µM -1.39832541932393 0.0956537058766128 no 3053 0.081007683975001 4479 1589775
SGTC_1495 4469-0029 237 µM -1.39840600765343 0.095640648666576 no 3054 0.0809955900655281 4433 793680
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.39996589660752 0.0953881681883993 no 3055 0.0807617655701957 4429 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1726 st035556 14.5795 µM -1.40143166178628 0.0951513698483177 no 3056 0.0805425148953314 4476 5919439
SGTC_1736 st036774 51 µM -1.40435235630388 0.0946808149968647 no 3057 0.0801069753782044 4482 1272247
SGTC_2622 2-methoxyxanthone 59.94 µM -1.40612559546817 0.0943959653878881 no 3058 0.0798434165778762 4421 71034 A hepatoprotective.
SGTC_953 1188-0045 9.7 µM -1.40626868537835 0.094373007293852 no 3059 0.0798221775708751 4435 6144426
SGTC_1779 st039427 55 µM -1.40659268143677 0.0943210388882879 no 3060 0.079774102239332 4427 1124498
SGTC_579 4491-1009 110 µM -1.41093798989424 0.0936260974720804 no 3061 0.0791314495852264 4532 1271041
SGTC_2365 9042475 200 µM -1.4112877565348 0.0935703244418031 no 3062 0.0790798915592069 4488 6464479
SGTC_729 4092-0585 94.1 µM -1.41288745035041 0.0933155534287063 no 3063 0.0788444098134937 4448 2169061
SGTC_903 1134-0042 114 µM -1.41551042167506 0.0928989224951725 no 3064 0.0784594474833681 4441 701009
SGTC_929 2805-0021 398 µM -1.41736878039968 0.0926045755358195 no 3065 0.0781875676958515 4485 3098024
SGTC_2789 5281112 71.43 µM -1.41778250449904 0.0925391394290011 no 3066 0.0781271368028344 4442 765948
SGTC_1679 SEC14.276 6.7 µM -1.41970003466178 0.092236302530761 no 3067 0.0778475140201102 4426 1005053 YMR079W SEC14
SGTC_2857 9024691 58.44 µM -1.42020088917108 0.0921573231820898 no 3068 0.0777746024397854 4472 16478292
SGTC_1984 st072354 53.1 µM -1.42300137134451 0.0917166397597623 no 3069 0.077367878855843 4321 5762938
SGTC_506 n9-isopropylolomoucine 153 µM -1.42501046905124 0.0914014515726961 no 3070 0.0770770874454368 4442 6610355
SGTC_1477 0139-0234 16 µM -1.42770905198791 0.0909793610837988 no 3071 0.0766878098222214 4455 620880
SGTC_2717 st081029 62.2815 µM -1.42998626235241 0.0906243046111914 no 3072 0.0763604809710465 4428 5292846
SGTC_3290 9121031 71.43 µM -1.43266047125862 0.0902086635337373 no 3073 0.0759774455880588 4468 17014854
SGTC_2899 9053889 58.44 µM -1.44045587449346 0.0890051384557721 no 3074 0.0748692327088061 4450 6470052
SGTC_246 cycloheximide 667 µM -1.44461985983964 0.0883671821173743 no 3075 0.0742823456430065 4376 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1799 st045822 46.1415 µM -1.45075778022708 0.0874330251753213 no 3076 0.0734236599195633 4445 3674992
SGTC_184 1494-0393 24.714 µM -1.45293141896186 0.0871039830489415 no 3077 0.0731213982212865 4454 3090647
SGTC_1457 k015-0032 57.3 µM -1.45641592671515 0.0865784344468257 no 3078 0.0726388376978152 4457 4302660
SGTC_768 0384-0033 77.3 µM -1.45911254373214 0.086173348640977 no 3079 0.0722670671583178 4423 3965305 YMR134W ERG29
SGTC_753 1322-0200 289 µM -1.45931191196206 0.0861434559245932 no 3080 0.0722396391464488 4521 5403907
SGTC_1737 st035557 69.7 µM -1.46043276059709 0.0859755433859705 no 3081 0.072085587287197 4307 5716916
SGTC_2346 9031566 143.75 µM -1.4621917871951 0.0857125203880173 no 3082 0.0718443307835499 4443 4771086
SGTC_604 1000-0114 314 µM -1.46354792385304 0.085510152132692 no 3083 0.0716587551196239 4481 1572745
SGTC_3339 9145883 14.936 µM -1.46639872457528 0.0850859110229539 no 3084 0.0712698468039217 4396 2030670
SGTC_619 1652-1634 108 µM -1.46824476842455 0.0848120352013637 no 3085 0.0710188738336697 4465 5400454
SGTC_326 k292-0812 17.5 µM -1.4686518833968 0.0847517253964594 no 3086 0.0709636172848246 4458 3579357
SGTC_2667 digitoxin 100 µM -1.4701556695151 0.0845292340574462 no 3087 0.0707597989395717 4438 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_674 0498-0004 451 µM -1.47199694937942 0.0842574061847084 no 3088 0.0705108506843869 4464 4231473
SGTC_261 5-fluorouridine 15.376 µM -1.47284535542504 0.0841323771394871 no 3089 0.070396369689537 4497 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_870 0573-2213 57.6 µM -1.47402708868119 0.0839584580529423 no 3090 0.0702371488947208 4465 3916321
SGTC_1828 st055811 49 µM -1.47738573119372 0.0834656310858059 no 3091 0.0697861344021135 4493 5877589
SGTC_439 amiodarone 34.4 µM -1.47770983903062 0.0834181887200891 no 3092 0.0697427298625578 4349 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1800 st050079 29.0735 µM -1.48293747813209 0.0826557730555002 no 3093 0.0690455113982637 4300 3645560
SGTC_1333 1482-0047 286 µM -1.48544105520657 0.0822925058434891 no 3094 0.0687135134764619 4519 3811116
SGTC_762 1165-0429 115 µM -1.48646085848976 0.0821448782395862 no 3095 0.0685786313278237 4480 5967793
SGTC_1313 1220-0047 237 µM -1.48769165501518 0.0819669728543529 no 3096 0.0684161146763738 4479 3528706
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.48820614827342 0.0818926915733486 no 3097 0.0683482681652251 4443 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_3014 9081533 49.47 µM -1.49078500528998 0.0815211267472033 no 3098 0.0680089748972182 4509 21367265
SGTC_1837 st055472 66.5 µM -1.49230653204164 0.0813025004513475 no 3099 0.0678094025633236 4532 676091
SGTC_395 anisomycin 6.25 µM -1.4980625199535 0.0804794303061483 no 3100 0.0670585038624636 4502 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_786 4544-0069 423 µM -1.49905675888079 0.0803379001933513 no 3101 0.0669294540376144 4480 748821 YLR208W SEC13
SGTC_500 h-89 112 µM -1.49950256005697 0.0802745014106152 no 3102 0.0668716525340947 4457 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1132 3456-3614 2.5 µM -1.50121341288951 0.0800315466232592 no 3103 0.0666501859240863 4475 3125502
SGTC_1469 k284-2957 126 µM -1.50202967778833 0.0799158265583503 no 3104 0.0665447222257492 4495 23884841
SGTC_1187 1391-0724 117 µM -1.50416703585307 0.0796134175072606 no 3105 0.0662691815757801 4543 6997986
SGTC_3340 9146634 11.102 µM -1.51423719267734 0.0782002576388456 no 3106 0.0649828458746797 4496 4907387
SGTC_2644 guaiazulene 100 µM -1.51583926962325 0.0779772009261794 no 3107 0.0647799998195916 4527 3515 A coloring agent.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.51998523913975 0.0774022002053217 no 3108 0.0642573427578868 4512 616764
SGTC_1420 4'-methoxyflavone 42 µM -1.5202880436419 0.0773603310523209 no 3109 0.064219298842619 4501 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3278 9139605 49.47 µM -1.52074393769442 0.0772973264686346 no 3110 0.064162054004141 4491 7958859
SGTC_55 0767-0285 6.563 µM -1.52309776942942 0.0769726468327245 no 3111 0.0638671234162979 4429 3116166
SGTC_1774 st048371 48.465 µM -1.52544991421208 0.0766492364153023 no 3112 0.0635734585331939 4507 4242727
SGTC_2685 mycophenolic acid 18.85 µM -1.52768196128482 0.0763432955630624 no 3113 0.0632957604824404 4511 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1031 k035-0009 16 µM -1.52964995953986 0.076074318787238 no 3114 0.0630516980497593 4549 5180959
SGTC_2819 7996655 46.38 µM -1.52989652397605 0.076040670435016 no 3115 0.0630211719591315 4482 6456960
SGTC_1197 1601-0112 267 µM -1.53216892043021 0.075731092450282 no 3116 0.0627403779272236 4481 7350313
SGTC_858 0438-0351 2.77 µM -1.53332675310574 0.0755737257674596 no 3117 0.0625976830350132 4492 2799119
SGTC_90 0870-0863 4.608 µM -1.53607936239047 0.0752006056222525 no 3118 0.062259458584944 4521 1738164
SGTC_658 3253-0951 102 µM -1.53687700633676 0.0750927467386082 no 3119 0.0621617156213447 4533 1184878
SGTC_1439 4092-1168 46 µM -1.53775461194167 0.0749742116395389 no 3120 0.062054312541548 4528 2886240
SGTC_3214 9129694 49.47 µM -1.5400996101985 0.0746581811518217 no 3121 0.0617680373972824 4520 17158655
SGTC_1770 st043884 66.3 µM -1.544756936329 0.0740335390114164 no 3122 0.0612025336088481 4527 670149
SGTC_2600 tangeritin 87.95 µM -1.54559614922535 0.0739214092797756 no 3123 0.0611010658949976 4433 68077 A bioactive flavone.
SGTC_1045 1348-1485 165 µM -1.54620338822409 0.0738403552277621 no 3124 0.0610277277483337 4495 6810614
SGTC_589 1227-0070 34.1 µM -1.54710523423805 0.0737201025025116 no 3125 0.0609189359961932 4568 2841384
SGTC_1668 st014914 51.6 µM -1.54825860156264 0.0735665299831526 no 3126 0.0607800236771597 4541 2839556
SGTC_1885 st057546 99.9 µM -1.54994065841103 0.0733430003587667 no 3127 0.0605778798543737 4554 702008
SGTC_2164 5685496 200 µM -1.55045125396898 0.0732752498736361 no 3128 0.0605166224006271 4458 759046
SGTC_2891 9063876 19.48 µM -1.55123168775452 0.0731717873164028 no 3129 0.0604230854297125 4548 6472478
SGTC_835 0312-0010 67.2 µM -1.55620549140514 0.0725150316689492 no 3130 0.059829617993605 4544 1626196
SGTC_325 2810-4341 181 µM -1.55701190913937 0.0724089766368955 no 3131 0.0597338289729561 4518 774970
SGTC_1664 st014217 9.02 µM -1.55777029884396 0.0723093464222592 no 3132 0.0596438545580372 4593 3982782
SGTC_593 1203-0218 61.7 µM -1.55883619716032 0.0721694961923749 no 3133 0.0595175772633685 4566 3666956
SGTC_705 1124-0212 310 µM -1.5652441933512 0.0713331066241862 no 3134 0.0587628314368126 4519 9554485
SGTC_1376 2910-0861 41.3 µM -1.56570730683321 0.0712729492633609 no 3135 0.058708577451957 4460 1112859
SGTC_2526 patulin 37.61 µM -1.5658836978322 0.0712500467288569 no 3136 0.0586879234973549 4539 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_323 4013-0906 34.3 µM -1.5689592145144 0.0708516303854857 no 3137 0.0583287213828309 4551 2910086
SGTC_742 0kpi-0133 140 µM -1.5724808896153 0.0703975211630373 no 3138 0.0579195338688707 4561 2728852
SGTC_2588 indole-3-carbinol 100 µM -1.57413083179499 0.0701855374911192 no 3139 0.0577286029861203 4506 3712 Induces cell cycle arrest.
SGTC_35 0133-0054 64.071 µM -1.57647502946855 0.0698852010105284 no 3140 0.0574581845228216 4494 99677
SGTC_2876 9059903 25.97 µM -1.57664183723522 0.0698638675010494 no 3141 0.0574389802024469 4525 6916095
SGTC_1948 st076329 66.6 µM -1.57889861707821 0.0695757340019888 no 3142 0.0571796566378963 4460 24208413
SGTC_2478 5763493 32.33 µM -1.58512269546776 0.0687858183685199 no 3143 0.0564692299952814 4486 1365576 YLR208W SEC13
SGTC_145 3737-0113 38.366 µM -1.5852236319392 0.0687730654486312 no 3144 0.0564577665212287 4524 6849351
SGTC_999 SEC7.066 22.7 µM -1.59003299273904 0.0681675323242634 no 3145 0.0559136841965235 4496 740511 YDR170C SEC7
SGTC_217 ketoconazole 989 nM -1.59071167994741 0.0680824130965659 no 3146 0.0558372385665903 4346 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1125 tnp00248 1.32998 µM -1.59340058266372 0.0677459840662522 no 3147 0.0555351775484683 4566 24207736
SGTC_938 3126-1755 342 µM -1.59407798125607 0.0676614324269179 no 3148 0.0554592849692454 4527 1777771
SGTC_2212 7123476 200 µM -1.59729037905434 0.0672615764742267 no 3149 0.0551004971987426 4596 1085715
SGTC_2322 7413319 38.22 µM -1.60482662742667 0.0663306905347699 no 3150 0.0542659821510715 4484 1840400
SGTC_2474 5321570 43.32 µM -1.60755062592306 0.0659966847255941 no 3151 0.0539668165953279 4553 2841384
SGTC_250 brefeldin a 552.239 µM -1.6144018775851 0.0651623724910712 no 3152 0.0532201423666048 4490 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3025 9087895 49.47 µM -1.61613044722312 0.0649531740622141 no 3153 0.0530330562876719 4539 17173641
SGTC_720 r052-1644 49.9 µM -1.6164788570848 0.0649110713039859 no 3154 0.0529954105152802 4552 1422863 YOR257W CDC31
SGTC_3024 9090631 49.47 µM -1.62411992886069 0.0639930218812316 no 3155 0.0521751077348062 4532 25236383
SGTC_2810 7959871 45.46 µM -1.62470630463997 0.0639229900243223 no 3156 0.0521125766775775 4506 2974535
SGTC_1875 nocodazole 6 µM -1.62656010925349 0.0637019790095514 no 3157 0.0519152786542492 4575 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2486 5283202 22.39 µM -1.63087499759585 0.0631898594178182 no 3158 0.0514583491866851 4560 1377751
SGTC_1467 k284-1082 293 µM -1.63228428656732 0.0630232919828902 no 3159 0.0513098059427589 4538 3334705
SGTC_415 dibenzyl ketone 100 µM -1.63253465680345 0.0629937358986742 no 3160 0.0512834518945244 4540 7593
SGTC_74 000s-0487 160.283 µM -1.63817948177116 0.0623302289211029 no 3161 0.050692129256487 4436 677548
SGTC_1889 st059080 5.18 µM -1.63819932971268 0.0623279055971272 no 3162 0.0506900597099846 4537 176925 Isolated from Daphnopsis sellowiana.
SGTC_10 0279-0212 42.575 µM -1.64009435206765 0.0621063924356992 no 3163 0.0504927752886845 4580 39851 YBR002C RER2
SGTC_358 0075-0058 9.45 µM -1.64013158994424 0.062102045783001 no 3164 0.0504889047154483 4514 1069125
SGTC_502 l-744,832 89.3 µM -1.64056937066106 0.062050962900123 no 3165 0.0504434187071079 4574 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1174 0739-0097 51.1 µM -1.64284459720812 0.0617860036020111 no 3166 0.0502075451634533 4582 728447
SGTC_3238 9133470 49.47 µM -1.64392208064877 0.0616608348697468 no 3167 0.0500961492544553 4568 3534688
SGTC_445 e6 berbamine 66 µM -1.64399708832065 0.0616521287803311 no 3168 0.0500884019086383 4562 6610268 A calcium/calmodulin antagonist.
SGTC_1106 tegaserod maleate 11.7 µM -1.64592214269279 0.0614290172855599 no 3169 0.049889894751921 4587 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2286 7945697 125 µM -1.64810717298213 0.0611765396400452 no 3170 0.0496653403201064 4534 1245733
SGTC_2096 5468907 200 µM -1.64989397151325 0.0609706805166562 no 3171 0.0494823119773568 4576 759785
SGTC_1194 1488-0194 225 µM -1.65900559125272 0.0599293305728478 no 3172 0.0485573328159891 4558 1391452
SGTC_811 0416-0114 265 µM -1.65942509542771 0.0598817237603288 no 3173 0.048515081429058 4581 6612453
SGTC_1047 2043-3044 82 µM -1.66742522465349 0.0589794983085868 no 3174 0.0477149407819465 4540 669592
SGTC_3304 9125678 46.087 µM -1.669028897481 0.0587999317034202 no 3175 0.0475558265015046 4517 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1190 1486-1332 13 µM -1.67115839992462 0.0585621503181234 no 3176 0.0473451973431131 4565 4150046
SGTC_975 1335-0046 28.5 µM -1.67125087800801 0.0585518412954199 no 3177 0.0473360672976434 4562 16486740
SGTC_583 1488-1091 88.9 µM -1.67168419258277 0.0585035563982223 no 3178 0.0472933064211087 4667 4303273
SGTC_2946 9065502 71.43 µM -1.67345840233905 0.0583061795476904 no 3179 0.0471185444775969 4453 16489101
SGTC_2997 9067075 71.4286 µM -1.67459193099126 0.058180351121189 no 3180 0.0470071617595484 4535 27209819
SGTC_3251 9135047 49.47 µM -1.67511694172476 0.0581221441417411 no 3181 0.0469556447774297 4617 17682963
SGTC_2393 9031399 185.94 µM -1.68038004496093 0.0575411590261243 no 3182 0.0464416980285935 4556 1526623 YDL150W RPC53
SGTC_2433 5607874 27.82 µM -1.68190395733352 0.0573737924849802 no 3183 0.046293732598536 4548 2252428
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.68256068622815 0.0573017842019926 no 3184 0.0462300838285963 4598 23665772 A membrane-active detergent.
SGTC_1872 amphotericin b 148 nM -1.6853941119587 0.0569919228762795 no 3185 0.0459562794500168 4591 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2415 st077333 57.7 µM -1.68562439852964 0.0569667969894447 no 3186 0.0459340833801525 4573 2766255
SGTC_394 menadione 8.33 µM -1.68870767960774 0.056631228808299 no 3187 0.0456377316072789 4575 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1938 st074717 56.4 µM -1.68950809408924 0.0565443709966216 no 3188 0.0455610510270576 4464 17250979
SGTC_2480 5767542 37.17 µM -1.69124218560692 0.056356554327974 no 3189 0.0453952784921371 4509 2867358
SGTC_1472 k841-0093 193 µM -1.69291689579222 0.0561756362668235 no 3190 0.0452356434051573 4639 X1472
SGTC_1349 flufenamic acid 69 µM -1.70252964810012 0.0551460186648594 no 3191 0.0443280627656393 4532 3371 A non-steroidal anti-inflammatory.
SGTC_2662 daunorubicin 22.37 µM -1.70497799976454 0.054886173360246 no 3192 0.0440992638127766 4474 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2532 xanthone 78.9 µM -1.70820264413873 0.054545417205172 no 3193 0.0437993740398738 4600 7020 An insecticide.
SGTC_2184 6075246 200 µM -1.71450450308333 0.0538843154579292 no 3194 0.0432180553821289 4579 2267320
SGTC_1404 3909-7820 48.3 µM -1.71520005724734 0.053811738201103 no 3195 0.0431542771960659 4580 23741373
SGTC_3084 9116877 49.47 µM -1.71595166304882 0.05373339930546 no 3196 0.0430854448877086 4554 27241325
SGTC_1818 st052136 56.3 µM -1.72168225408834 0.0531390731877974 no 3197 0.0425635468571441 4257 674169
SGTC_2860 9025725 38.96 µM -1.72370532797383 0.052930506982036 no 3198 0.04238052634903 4626 40546248
SGTC_2487 5918373 44.05 µM -1.73306002324608 0.0519745262051276 no 3199 0.0415425004207199 4635 2876279
SGTC_3176 9106582 49.47 µM -1.7432764307063 0.0509462111463756 no 3200 0.040642670160519 4633 17018027
SGTC_297 0986-0032 24 µM -1.75139147083771 0.0501410017370807 no 3201 0.0399392505790169 4590 2847425
SGTC_2960 9079389 5.97 µM -1.75371309733834 0.0499125159711515 no 3202 0.0397398400868876 4570 16457355
SGTC_2071 5230951 39.92 µM -1.7644170810214 0.0488697904414448 no 3203 0.0388308922304471 4649 1799272
SGTC_2245 6637752 200 µM -1.76532426183974 0.048782223848403 no 3204 0.0387546421031604 4623 681890
SGTC_882 0843-0131 351 µM -1.76732728836515 0.0485893236948674 no 3205 0.0385867161667151 4639 5425421
SGTC_2693 st077581 40.7 µM -1.7677863492965 0.0485452001465944 no 3206 0.0385483139232737 4569 25238761
SGTC_1107 amlodipine 47 µM -1.77178859399052 0.0481618723469884 no 3207 0.038214828319064 4182 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_877 0771-0151 33.1 µM -1.77187360520095 0.0481537564706951 no 3208 0.0382077703885527 4622 6166523
SGTC_859 0439-0102 54.6 µM -1.77266937861724 0.0480778383853438 no 3209 0.0381417540084116 4648 610143
SGTC_3315 9136395 68.55 µM -1.77893145533402 0.0474837634342449 no 3210 0.037625500170818 4618 16876844
SGTC_464 bw-b 70c 158 µM -1.78005633853118 0.0473776729794271 no 3211 0.037533370522957 4610 5353454
SGTC_2545 solidagenone 89.61 µM -1.78461682757326 0.0469495067658404 no 3212 0.0371617450149537 4584 6708572 An anti ulcer agent
SGTC_2647 atorvastatin 60.16 µM -1.78680514196902 0.046745159234224 no 3213 0.0369844940007805 4620 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2624 nerol 100 µM -1.7921289890783 0.046250990717832 no 3214 0.0365561531152648 4545 637566 A natural product oil.
SGTC_1415 3966-0071 78.1 µM -1.79334095236576 0.0461390824768257 no 3215 0.0364592114760402 4546 2893185
SGTC_846 0335-0850 148 µM -1.79531194376139 0.0459575528900757 no 3216 0.0363020065734257 4622 6819598
SGTC_2123 5259487 200 µM -1.79726019246689 0.0457786822922749 no 3217 0.0361471613362967 4625 2173474
SGTC_987 1497-1013 404 µM -1.80123555749483 0.0454154359496451 no 3218 0.0358328800704726 4629 1676435
SGTC_1129 3453-1384 223 µM -1.806104555305 0.0449736967628634 no 3219 0.0354510047142399 4608 1084452
SGTC_2906 7926292 26.41 µM -1.80619415299098 0.0449656005473289 no 3220 0.0354440089614794 4610 2966319
SGTC_2237 6667747 47.222 µM -1.81626274695452 0.0440632311062019 no 3221 0.034665038442453 4627 729940 YDL015C TSC13
SGTC_1028 k015-0029 4.8 µM -1.81746340209226 0.0439566070649565 no 3222 0.0345730936307607 4626 4588309
SGTC_564 3555-0129 330 µM -1.8190795656421 0.0438134125052363 no 3223 0.0344496460567758 4578 563260
SGTC_581 0958-0271 211 µM -1.8211583952038 0.043629778602492 no 3224 0.0342913913765618 4639 4591145
SGTC_3119 9125183 49.47 µM -1.82198848455575 0.0435566262011566 no 3225 0.0342283664704829 4570 22695334
SGTC_1742 st038235 28.8875 µM -1.8228048817313 0.0434847770231027 no 3226 0.0341664740535427 4646 564103 YBR002C RER2
SGTC_840 0245-0196 390 µM -1.82523516041762 0.0432714600999112 no 3227 0.03398277501905 4695 3827528
SGTC_378 3970-0959 8.33 µM -1.83214422791469 0.0426696318766981 no 3228 0.0334649677589677 4643 6615653
SGTC_2863 9028737 58.44 µM -1.86269826486037 0.0400888156324297 no 3229 0.0312523650757491 4651 6460917
SGTC_2752 diclazuril 33.15 µM -1.86502003545689 0.0398980022019497 no 3230 0.0310892979519659 4559 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_466 geldanamycin 89.2 µM -1.86608527293761 0.0398107036271334 no 3231 0.0310147180342726 4683 5288382 HSP90 inhibitor.
SGTC_1066 ketoconazole 628 nM -1.86924157676917 0.0395529488638864 no 3232 0.0307946061209847 4684 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2063 5246145 200 µM -1.87236131706912 0.0392995154727471 no 3233 0.0305783164683405 4654 711240
SGTC_1141 3253-0389 52.6 µM -1.87248285890739 0.0392896687767268 no 3234 0.0305699155772542 4641 5402031
SGTC_2953 9074162 66.49 µM -1.88370609193481 0.0383890361650453 no 3235 0.029802370978092 4637 16451992
SGTC_2934 9036370 36.88 µM -1.88774404153087 0.0380691479074901 no 3236 0.0295301603850122 4619 6462800
SGTC_2716 st080858 38.6235 µM -1.88814695979646 0.0380373481890821 no 3237 0.0295031120323452 4630 5296050
SGTC_2085 5307070 144.047 µM -1.88855986364956 0.0380047828575691 no 3238 0.0294754146766635 4601 2840351
SGTC_1001 4048-4355 44.4 µM -1.8934157923849 0.0376235044272206 no 3239 0.0291512984512948 4646 21824233
SGTC_2363 9053361 176 µM -1.89349802155359 0.0376170749355828 no 3240 0.0291458355390399 4653 6469797 YMR079W SEC14
SGTC_1877 wortmannin 25 µM -1.9086065365397 0.0364508776816772 no 3241 0.0281564340390673 4656 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2121 5257820 149.641 µM -1.91155269721584 0.036226952494069 no 3242 0.0279667957550827 4668 791256
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.91463387007284 0.0359939716940318 no 3243 0.0277696062612135 4680 688788
SGTC_286 k060-0067 22.9 µM -1.91810110531376 0.0357332680766161 no 3244 0.0275490961772024 4688 5985051
SGTC_1324 1418-0026 34.4 µM -1.92598188185912 0.0351464607818864 no 3245 0.0270533180950012 4689 1372513
SGTC_2641 levomentholum 100 µM -1.92624962451288 0.0351266642113695 no 3246 0.0270366060987562 4677 16666
SGTC_1505 k297-0037 20.6 µM -1.92886717093162 0.0349336075133118 no 3247 0.0268736771464628 4655 4089396
SGTC_2941 9056145 11.23 µM -1.93800266552006 0.0342666336697408 no 3248 0.026311448671486 4629 2119517
SGTC_2625 euphol 100 µM -1.94163285246973 0.0340045195452939 no 3249 0.0260907814145845 4660 6708538 A triterpene alcohol.
SGTC_2623 humulene 100 µM -1.94291322162986 0.0339124659752846 no 3250 0.0260133220785265 4636 6187145 An anti-inflammatory.
SGTC_2854 9024559 71.43 µM -1.94934355241196 0.033453244894435 no 3251 0.0256272053693091 4645 3163529
SGTC_2543 pimpinellin 60.67 µM -1.96382014381662 0.0324381217652441 no 3252 0.0247754765946302 4565 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2332 7982454 138.89 µM -1.96668425867533 0.0322403272245048 no 3253 0.0246098113805246 4583 2981748
SGTC_3040 9091894 49.47 µM -1.97215836693825 0.0318650570622506 no 3254 0.0242957653483753 4614 25236966
SGTC_1479 0549-0158 134 µM -1.97349466483997 0.0317739988996212 no 3255 0.0242196159056919 4724 5440202
SGTC_2200 6600604 21.907 µM -1.97446673120465 0.0317078953994131 no 3256 0.024164348365403 4697 2904777
SGTC_1778 st046819 58.9 µM -1.97648836534808 0.0315707819445715 no 3257 0.024049746092844 4709 671715
SGTC_154 3389-1638 511.116 µM -1.97835510804025 0.0314446092317632 no 3258 0.0239443301545226 4684 5238686
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.98215215506982 0.0311892539014433 no 3259 0.0237311068605159 4623 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_231 b-estradiol 524 µM -1.9872806025597 0.0308470857452141 no 3260 0.0234456550016872 4699 450 A steroid.
SGTC_376 3970-0862 59.1 µM -1.99913703095188 0.0300679136247773 no 3261 0.0227967647064236 4690 3135186
SGTC_9 0092-0002 10.449 µM -1.99925005079853 0.0300605655244385 no 3262 0.022790652807595 4686 759368
SGTC_3219 9131112 49.47 µM -2.00722721183385 0.0295456711220306 no 3263 0.0223627377057719 4565 17612988 YMR079W SEC14
SGTC_1471 k673-0312 37 µM -2.01467525790441 0.0290715581729355 no 3264 0.0219693431478081 4695 24099884
SGTC_2150 5556613 200 µM -2.01587007745784 0.0289960923097664 no 3265 0.0219067816437377 4710 743190
SGTC_1470 k295-0292 231 µM -2.01923604241505 0.0287843698473461 no 3266 0.0217313459242032 4730 5045612
SGTC_505 gw-5074 63.9 µM -2.0199143342255 0.0287418606105937 no 3267 0.0216961370855419 4669 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1996 st072960 66.8 µM -2.02748936648327 0.0282706624683331 no 3268 0.0213061954144358 4712 1719405
SGTC_1697 st025554 27.742 µM -2.02953192468079 0.0281447132752321 no 3269 0.021202070361565 4713 1269519
SGTC_3284 9108171 64.8615 µM -2.03457174042296 0.0278359430259423 no 3270 0.0209469916284686 4658 8687505
SGTC_651 3253-0966 34.4 µM -2.03560976950787 0.027772698709377 no 3271 0.0208947780021794 4707 781462
SGTC_85 0868-0259 160.055 µM -2.0401833055228 0.0274954696893575 no 3272 0.0206660359415856 4661 83173
SGTC_1064 honokiol 6.76 µM -2.04022265823316 0.0274930943376642 no 3273 0.0206640769845362 4685 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2918 7977171 22.06 µM -2.04502339213218 0.0272046001809326 no 3274 0.0204262759861982 4684 2236483
SGTC_1926 methyl fluorone black 53.6 µM -2.04651724560258 0.0271153457791961 no 3275 0.0203527537461344 4369 72721 Reacts with homocysteine.
SGTC_1264 0783-0040 158 µM -2.04817395227463 0.0270166471534868 no 3276 0.0202714788807984 4631 2855798
SGTC_357 1325-0123 420 µM -2.06007067851937 0.0263166697281229 no 3277 0.0196958922521324 4684 1098503
SGTC_2793 7325131 81.82 µM -2.06623687785278 0.0259598701062884 no 3278 0.0194030591569813 4665 4176441
SGTC_3211 9128781 49.47 µM -2.07605382831432 0.0254001790642873 no 3279 0.0189444864068329 4604 17194361
SGTC_446 go6976 132 µM -2.13863692899705 0.0220648728264291 no 3280 0.0162325421293134 4716 3501 A protein kinase C inhibitor.
SGTC_2602 kawain 100 µM -2.15177054013523 0.0214139934440956 no 3281 0.0157077156032375 4685 5369129
SGTC_2896 9052656 71.43 µM -2.15972169130809 0.0210278922381015 no 3282 0.0153971104768506 4370 6469436
SGTC_1493 4348-0038 111 µM -2.17482343574347 0.0203107723238212 no 3283 0.014821675085125 4730 800424
SGTC_647 0140-0236 81 µM -2.18785969052624 0.0197085104328202 no 3284 0.0143399121509001 4733 990837
SGTC_1185 1319-0113 81.3 µM -2.18846375931386 0.0196809745549913 no 3285 0.0143179191615773 4740 4672763
SGTC_2061 5245884 80.95 µM -2.20757614245464 0.0188264687125622 no 3286 0.0136369168766657 4713 573863
SGTC_1669 st015249 58.4 µM -2.2152086137931 0.0184941539823261 no 3287 0.0133728744614693 4777 722793
SGTC_2064 5220758 200 µM -2.21724496353025 0.0184063409033403 no 3288 0.0133031782687271 4729 788518
SGTC_649 1123-0311 367 µM -2.22023727385499 0.0182779486228164 no 3289 0.013201332672256 4641 693629 YIL048W NEO1
SGTC_401 neomycin 50 µM -2.22282963559195 0.0181673347632135 no 3290 0.0131136449642289 4732 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2551 apiole 73.87 µM -2.22939421412475 0.0178897784451366 no 3291 0.012893843434004 4704 10659 A possible DNA adduct former.
SGTC_993 3909-8757 62.7 µM -2.23366493448592 0.017711156979843 no 3292 0.0127525639385544 4709 4288324 YLR208W SEC13
SGTC_617 3770-0098 35 µM -2.2353913276887 0.0176393842786649 no 3293 0.0126958344795121 4688 5962639
SGTC_2859 9028643 45.46 µM -2.24960127298652 0.0170579978661773 no 3294 0.012237133789824 4618 17151580
SGTC_1974 st069448 26.9 µM -2.28628470109238 0.0156323253767512 no 3295 0.0111188041559428 4725 6323587 YNR016C ACC1
SGTC_2519 cryptotanshinone 88.04 µM -2.28661256776657 0.0156200587612994 no 3296 0.0111092235115756 4731 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2537 larixol 68.93 µM -2.28673425713757 0.0156155080471679 no 3297 0.0111056694342736 4718 6708759
SGTC_2531 methyl deoxycholate 70.07 µM -2.29901927371029 0.0151619124264211 no 3298 0.0107519224438796 4681 16667744 Haematoxylin.
SGTC_1041 0206-0046 107 µM -2.30569551358095 0.0149201894091329 no 3299 0.0105638259898552 4732 50494
SGTC_412 gemfibrozil 100 µM -2.30950730911952 0.0147836692985372 no 3300 0.0104577232811073 4725 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_971 1315-0384 26.7 µM -2.31704941988368 0.0145167108588748 no 3301 0.0102505199166401 4752 6769120
SGTC_1718 roemerine 11.9335 µM -2.31823211150725 0.0144752272416781 no 3302 0.0102183548647236 4400 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2605 digitonin 300 nM -2.35083448942931 0.0133711866806179 no 3303 0.0093656818203515 4733 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_582 0987-0078 156 µM -2.35966501810006 0.0130849677798569 no 3304 0.00914572182212387 4767 1625765
SGTC_1004 4084-0029 199 µM -2.38588183746954 0.0122662017499124 no 3305 0.00851911226533952 4743 716894 YLR208W SEC13
SGTC_684 1140-0066 328 µM -2.38951776701006 0.0121562302507954 no 3306 0.00843525392419282 4750 6813534
SGTC_1344 1488-0097 29.1 µM -2.39082490405206 0.0121169042482345 no 3307 0.00840528392494648 4760 747966
SGTC_2257 7960413 200 µM -2.40400305664443 0.0117265529600436 no 3308 0.00810831884560686 4767 2974689 YIL048W NEO1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.43397075975403 0.0108792879160885 no 3309 0.00746710072707005 4755 5024745
SGTC_151 3013-0144 2.285 µM -2.44049396442191 0.0107020863606395 no 3310 0.00733359552020122 4553 906558 YHR107C CDC12
SGTC_1980 st071811 45.7 µM -2.44813087666529 0.0104978294410566 no 3311 0.00717997420300835 4782 4974850
SGTC_507 nimesulide 162 µM -2.45026052057284 0.0104414791856184 no 3312 0.00713764434536537 4765 4495 A COX2 inhibitor.
SGTC_62 0180-0423 3.232 µM -2.45756702224263 0.0102501485408083 no 3313 0.00699408534421257 4736 30102 YGL099W LSG1
SGTC_739 1486-1183 203 µM -2.46915151356692 0.00995305869197613 no 3314 0.00677169305471602 4758 4346692
SGTC_3345 9148410 3.559 µM -2.47692206525784 0.00975801677842707 no 3315 0.00662604177050723 4723 4903596
SGTC_863 0466-0191 129 µM -2.48322725967261 0.00960221761997782 no 3316 0.00650989973151292 4783 765160 YPR165W RHO1
SGTC_1308 1187-1617 41.4 µM -2.49120429329416 0.00940822644131871 no 3317 0.00636554467244656 4767 2882570
SGTC_244 nsc-207895 1.295 µM -2.50889276054595 0.00899025234687747 no 3318 0.00605551229643105 4722 42640
SGTC_1137 ixabepilone 100 µM -2.52947117934419 0.0085245357902547 no 3319 0.00571172777442347 4726 154225 A novel microtubule stabilizer.
SGTC_2243 6634756 200 µM -2.53088920312482 0.00849323805865105 no 3320 0.00568868907243779 4754 885676
SGTC_1611 st001856 99.4 µM -2.54757005838336 0.00813257020350458 no 3321 0.00542380347774901 4772 647478
SGTC_2094 5332512 191.667 µM -2.57455543511116 0.00757756239022488 no 3322 0.00501845005851012 4783 755774
SGTC_574 1315-0397 40 µM -2.60344450057532 0.00702062977181775 no 3323 0.00461461044942545 4763 6794277
SGTC_273 hydroxyurea 18.1 mM -2.60974945254862 0.00690399693962403 no 3324 0.00453042788754446 4787 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1789 tunicamycin 25 nM -2.61054049028926 0.00688948531284294 no 3325 0.00451996348868139 4739 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1913 st060213 96.1 µM -2.61938140687967 0.00672912192256669 no 3326 0.00440446979420282 4749 688959
SGTC_2829 7992743 58.44 µM -2.62222416059892 0.00667826336030781 no 3327 0.00436789759716092 4733 16462845
SGTC_65 0798-0905 34.986 µM -2.62962773187249 0.00654740030263122 no 3328 0.00427392068272524 4734 3602145
SGTC_920 mycophenolic acid 780.421 nM -2.65812266720474 0.00606464982260649 no 3329 0.0039288643414585 4755 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_452 diindolylmethane 8 µM -2.66465870451681 0.00595847011330916 no 3330 0.00385332463372377 4776 3071 Inhibits expression of several cancer promoting factors.
SGTC_1916 st067606 49.2 µM -2.67509973200491 0.00579227024171756 no 3331 0.00373535112962041 4714 19590279
SGTC_2522 biochanin a 4.94 µM -2.76185458776928 0.00456292531030531 no 3332 0.0028737034776474 4763 5280373 A possible chelator.
SGTC_2021 4019055 173 µM -2.78258998749693 0.00430603678450799 no 3333 0.00269634540997378 4666 44827708 YER133W GLC7
SGTC_2616 abietic acid 100 µM -2.83432846662661 0.00372054035002668 no 3334 0.00229610520310999 4776 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_374 0880-0231 82.3 µM -2.83674608161593 0.00369501668204886 no 3335 0.0022787920907124 4718 6833587
SGTC_431 k089-0097 107 µM -2.84120822575392 0.00364832030318828 no 3336 0.00224714784373411 4578 5499420
SGTC_1688 st021091 57.6 µM -2.88192005291141 0.00324611694786177 no 3337 0.00197630003286995 4799 3656366
SGTC_682 0kpi-0099 17 µM -2.90442499845947 0.00304132951940766 no 3338 0.00183964172175723 4785 1714895 YML126C ERG13
SGTC_2550 chrysin dimethyl ether 71.87 µM -2.92806573574276 0.00283880828613504 no 3339 0.00170538962523996 4770 88881 An O-methylated flavonoid and antioxidant.
SGTC_1712 st032288 53.4 µM -2.93603683125365 0.00277331617772115 no 3340 0.00166217424607406 4693 2883011
SGTC_1772 st048439 82.2 µM -3.00058615392094 0.00229118547626948 no 3341 0.00134730256913468 4795 2927068 YDL195W SEC31
SGTC_2508 celastrol 40.54 µM -3.06644144441895 0.00187877780747159 no 3342 0.00108311616582797 4785 122724 Celastrol is a natural product and antioxidant.
SGTC_915 methyl methanesulfonate (MMS) 110 mM -3.25701890464285 0.00103636484099693 no 3343 0.000562944671170737 4779 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -3.25905259723948 0.00102963584721797 no 3344 0.000558924706640564 4801 6708630 An antioxidant.
SGTC_2328 6201408 200 µM -3.32238072051355 0.000839125621087444 yes 3345 0.000446264110095843 4776 2890418
SGTC_2834 9001755 58.44 µM -3.39252329868886 0.000666318325452893 yes 3346 0.00034626021147094 4727 2989575
SGTC_3299 9121982 43.1275 µM -3.40231495262486 0.000644996340930773 yes 3347 0.000334087935714795 4794 17594604 YPL160W CDC60
SGTC_2093 5331342 194.4 µM -3.8157484556361 0.000151603695043133 yes 3348 6.78853817639307e-05 4806 33839
SGTC_256 clotrimazole 625 nM -3.84390210969979 0.000136637995240241 yes 3349 6.05466622155249e-05 4797 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2316 5844804 197.44 µM -3.9141522103264 0.000105110949554686 yes 3350 4.53611981691978e-05 4798 776813
SGTC_515 4092-1064 102 µM -3.97030906069281 8.49670217543685e-05 yes 3351 3.58897303260963e-05 4789 717353
SGTC_907 3448-6986 75.5 µM -4.00463732877034 7.45051546963457e-05 yes 3352 3.10563498343581e-05 4804 590582
SGTC_457 grayanotoxin iii 135 µM -4.0582888824958 6.05501974224306e-05 yes 3353 2.47167971492279e-05 4771 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_263 alizarin 107.927 µM -4.32868655118614 2.04971986297652e-05 yes 3354 7.5000621500507e-06 4809 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1787 fluconazole 80 µM -6.0996895180249 3.49744125231081e-09 yes 3355 5.31373445662327e-10 4775 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C