SGTCid condition conc unit MNN11|YJL183W.score MNN11|YJL183W.strain.pval MNN11|YJL183W.strain.significant MNN11|YJL183W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2399 5884133 200 µM 14.9621755961389 1.70458602669863e-39 yes 1 6.48575614200515e-51 5 722445 SGTC_2350 9023895 38.85 µM 8.77558187522042 7.99832729702048e-15 yes 2 8.5011217507098e-19 2 2997209 SGTC_911 3456-4043 236 µM 6.95062515765023 5.97013960692559e-10 yes 3 1.81835495892449e-12 1 914281 SGTC_119 0121-0043 24.815 µM 6.94945242100105 6.00850610619993e-10 yes 4 1.83353385035188e-12 17 1092378 SGTC_878 0828-0289 13.7 µM 6.14478503585153 3.82257139427119e-08 yes 5 4.00359400802331e-10 13 745350 YLR208W SEC13 SGTC_1853 st056710 91.2 µM 6.08972073646944 4.99006961792736e-08 yes 6 5.655390711861e-10 3 269167 SGTC_2829 7992743 58.44 µM 5.81174670116663 1.85132327126698e-07 yes 7 3.09121692445096e-09 8 16462845 SGTC_121 0557-0495 61.343 µM 5.72722477433636 2.72687687148792e-07 yes 8 5.10434344822092e-09 21 3104427 SGTC_1097 itavastatin 7.23 µM 5.66128344779589 3.67517562299075e-07 yes 9 7.51225099504277e-09 8 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2582 agaric acid 100 µM 5.48316257647485 8.09824379536085e-07 yes 10 2.08894370855407e-08 190 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_18 0111-0177 500 nM 5.38879105477513 1.21911258425169e-06 yes 11 3.54666074328305e-08 28 721752 SGTC_2924 9010168 62.78 µM 5.06180930580903 4.780602345182e-06 yes 12 2.07648152242745e-07 15 2993929 SGTC_1457 k015-0032 57.3 µM 5.00135581475806 6.10168760024075e-06 yes 13 2.84642673166224e-07 14 4302660 SGTC_663 1486-0733 13.9 µM 4.85319728368411 1.0970252157669e-05 yes 14 6.07433633719564e-07 33 722445 YPR165W RHO1 SGTC_2851 9015922 71.43 µM 4.65818231559887 2.31678954802603e-05 yes 15 1.59506815516022e-06 21 2996893 SGTC_989 1501-0895 10.3 µM 4.63041541940134 2.57116448708642e-05 yes 16 1.82466415659672e-06 3 2830112 SGTC_976 1348-1067 47.6 µM 4.62121838573657 2.66110151242414e-05 yes 17 1.90746464093716e-06 15 5310671 YGL099W LSG1 SGTC_179 1273-0063 6.77 µM 4.61787388676079 2.69454004525997e-05 yes 18 1.93845868786817e-06 15 3108139 SGTC_2460 5552655 174.22 µM 4.588434871732 3.00654371342035e-05 yes 19 2.2329079318866e-06 17 5401989 SGTC_975 1335-0046 28.5 µM 4.48098739391895 4.46069227419472e-05 yes 20 3.71492501593193e-06 21 16486740 SGTC_1388 3346-4487 254 µM 4.41409462131282 5.67831770113774e-05 yes 21 5.07167950090422e-06 12 3345614 SGTC_3333 9141820 12.094 µM 4.31906069355494 7.95603322854386e-05 yes 22 7.83473442587462e-06 11 1939433 SGTC_132 0417-1715 25.805 µM 4.23969041567691 0.00010491622702985 yes 23 1.11914130064757e-05 17 6769098 SGTC_800 3448-7362 155 µM 4.23597404068367 0.000106272166989092 yes 24 1.1378153425001e-05 140 15991913 SGTC_2137 5261020 140 µM 4.23576973983762 0.000106347182430187 yes 25 1.13885046522034e-05 34 763655 SGTC_2391 6285546 200 µM 4.15747827451767 0.000139057370129841 yes 26 1.60889932879081e-05 12 846083 SGTC_131 0141-0277 33.849 µM 4.15730925578157 0.000139137231212627 yes 27 1.61008971736429e-05 30 1547771 SGTC_2007 4011539 71.82 µM 4.11741976572979 0.000159235043839652 yes 28 1.91568925379847e-05 52 45595301 SGTC_2357 9067248 200 µM 4.1012652271338 0.000168122617108053 yes 29 2.05448630906095e-05 13 9150235 SGTC_1099 5-nonyloxytryptamine 2.85 µM 4.04109729752755 0.000205473447350321 yes 30 2.66008389012011e-05 16 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_436 n,n-dimethylsphingosine 3.3 µM 3.9321873245871 0.000293477872539963 yes 31 4.20882148031004e-05 29 5282309 SGTC_2888 9058547 12.99 µM 3.92029766984606 0.000304966098098986 yes 32 4.42198305348921e-05 5 16476514 SGTC_124 0136-0217 7.121 µM 3.90613647598153 0.000319194901943287 yes 33 4.68917785709751e-05 58 3976905 SGTC_1316 1272-0050 65.9 µM 3.90243994284653 0.000323009421057475 yes 34 4.7613935387714e-05 9 7340392 SGTC_3202 9113761 49.47 µM 3.88848988249412 0.0003377899177686 yes 35 5.04349371843072e-05 48 4798415 SGTC_2925 9010536 32.5 µM 3.88320686255423 0.000343549763716569 yes 36 5.15438967507061e-05 54 2994177 SGTC_1597 7-benzyloxygramine 47.5 µM 3.88045410902542 0.000346587020364711 yes 37 5.21308083437838e-05 126 260807 SGTC_1908 st060353 56.5 µM 3.85057433059496 0.000381199632036324 yes 38 5.89205790501034e-05 41 4227716 SGTC_1905 st060207 84.5 µM 3.85009005677213 0.000381786166147638 yes 39 5.90372011015383e-05 13 1948547 SGTC_2508 celastrol 40.54 µM 3.82255300798314 0.000416550279290095 yes 40 6.60385369981379e-05 21 122724 Celastrol is a natural product and antioxidant. SGTC_1247 0448-0043 5.84 µM 3.79037868016012 0.00046087983868248 yes 41 7.52088940650397e-05 53 3089013 YGL099W LSG1 SGTC_2242 6630449 61.2675 µM 3.75055734662773 0.00052179347193498 yes 42 8.82209724196657e-05 50 691249 YDR170C SEC7 SGTC_951 1171-0579 82.7 µM 3.7480544074301 0.000525860591304508 yes 43 8.91058009486613e-05 93 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_435 c-PAF 6.7 µM 3.69406604746402 0.000621052467391999 yes 44 0.000110348218988726 56 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2536 dehydroabietamide 32.04 µM 3.65763724582248 0.000694017979278067 yes 45 0.000127275481473627 47 3983547 SGTC_1712 st032288 53.4 µM 3.64996079311129 0.000710368746574507 yes 46 0.000131140169596023 212 2883011 SGTC_206 4546-0025 72.014 µM 3.60169584528355 0.000821577962964014 yes 47 0.00015807406078834 90 6620745 YIL048W NEO1 SGTC_2286 7945697 125 µM 3.59240895005057 0.00084473306768572 yes 48 0.000163817573330746 70 1245733 SGTC_1100 amiodarone 5.07 µM 3.58101721015013 0.000873955595013898 yes 49 0.000171129553052991 25 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2009 4012297 12.05 µM 3.58054218365994 0.000875194102622909 yes 50 0.000171440989660197 79 45595307 SGTC_2999 9069765 71.4286 µM 3.56220319511366 0.000924260080110893 yes 51 0.000183877783587506 44 2097066 SGTC_3094 9117742 49.47 µM 3.52460307196419 0.00103285245866855 no 52 0.000212058889710875 37 17149698 SGTC_2057 5236571 38.335 µM 3.49915540281983 0.00111286047963662 no 53 0.00023336723478118 49 54684039 YBR257W POP4 SGTC_1466 k213-0079 57.5 µM 3.456736930863 0.00125894165058655 no 54 0.000273379161722094 32 3657981 SGTC_1790 st045711 43.5 µM 3.44582578858693 0.0012992529963899 no 55 0.000284658627144604 26 585119 SGTC_2953 9074162 66.49 µM 3.43875004549043 0.00132602160559857 no 56 0.000292203277845786 42 16451992 SGTC_1184 1269-1718 139 µM 3.43064592027443 0.00135729946290737 no 57 0.0003010730081763 49 5403821 SGTC_142 0335-0849 62.6745 µM 3.40819115967597 0.00144751760520317 no 58 0.00032697532549136 163 3889043 YPR107C YTH1 SGTC_306 1672-3436 11.6 µM 3.39213455307644 0.00151534999765107 no 59 0.000346751874813064 30 6797378 SGTC_531 3788-1495 174 µM 3.34673694340042 0.00172311847048979 no 60 0.000408843825501253 40 2896655 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 3.33777800533461 0.00176706343470825 no 61 0.000422255961209845 44 6708514 SGTC_389 tpck 16.7 µM 3.33413398009268 0.00178522783285316 no 62 0.000427827158941857 46 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1925 st057770 10.1 µM 3.310155463525 0.00190905125986914 no 63 0.000466220832139317 38 5989122 SGTC_985 1493-0307 8.71 µM 3.26203891255487 0.00218134514039662 no 64 0.000553069792655122 37 3278274 SGTC_708 3448-5400 146 µM 3.26002384705142 0.00219348108666481 no 65 0.000557014233665485 73 3462195 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 3.24810862398684 0.00226650105897153 no 66 0.000580874552217696 66 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1955 wogonin 32.4 µM 3.18410524101772 0.00269775851317778 no 67 0.000726011055250399 43 5281703 A flavanone. SGTC_611 3453-1652 23.7 µM 3.15298686580635 0.00293310674960405 no 68 0.000808045389945133 59 1560575 SGTC_3174 9107204 49.47 µM 3.12929722333441 0.00312450932903651 no 69 0.0008761248340885 68 3938802 SGTC_2235 salicylic acid 500 µM 3.12309467771236 0.00317644644441624 no 70 0.000894800848341581 12 338 A COX inhibitor and kinase inhibitor. SGTC_1512 0259-0544 12.2 µM 3.12179780371074 0.00318740355143288 no 71 0.000898751730362738 58 18476 SGTC_558 k064-0027 21.3 µM 3.12046401044729 0.00319870805075842 no 72 0.000902831805012382 69 5088526 SGTC_2899 9053889 58.44 µM 3.1065479746585 0.00331882244174284 no 73 0.00094642795927848 27 6470052 SGTC_1220 1838-0075 193 µM 3.08296991780923 0.00353161635139854 no 74 0.00102472935556273 41 5529645 SGTC_2310 7668677 200 µM 3.0730397826319 0.00362484540696248 no 75 0.00105945119003273 81 2197143 SGTC_202 3594-0513 34.79 µM 3.06503852180501 0.00370156556122702 no 76 0.00108820981373264 30 708429 SGTC_3037 9091026 49.47 µM 3.06467249600762 0.00370510978744825 no 77 0.00108954236544389 203 25236398 YIL048W NEO1 SGTC_3214 9129694 49.47 µM 3.05848874960861 0.00376544884643446 no 78 0.0011122821595254 65 17158655 SGTC_1632 st005650 90 µM 3.05446552435614 0.00380517784345177 no 79 0.00112730963178607 67 2759605 SGTC_365 0121-0052 13.6 µM 3.0266325901487 0.00409047203453227 no 80 0.00123647169203697 125 3101739 SGTC_943 3253-1379 105 µM 3.02402260280946 0.00411818288483 no 81 0.00124718900960227 60 668464 SGTC_351 caspofungin 25 nM 3.01918581877716 0.00416998060709214 no 82 0.00126727512321213 170 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2249 haloperidol 116.36 µM 3.01674038138214 0.0041963902835367 no 83 0.00127754271113439 189 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2175 5807670 165.306 µM 2.98693926231162 0.0045304609872084 no 84 0.00140892849965883 61 241186 SGTC_2266 7929956 200 µM 2.93361721767941 0.00518787253141859 no 85 0.00167518559041467 86 2967153 SGTC_2447 5741742 33.78 µM 2.93358743415235 0.00518826229867192 no 86 0.00167534632603411 79 1776504 SGTC_1004 4084-0029 199 µM 2.91734299804036 0.00540477104400523 no 87 0.00176513662494519 65 716894 YLR208W SEC13 SGTC_2041 5107442 45.335 µM 2.90469964110479 0.00557880404257217 no 88 0.00183802840664731 81 793005 SGTC_3091 9116372 49.47 µM 2.90455679506999 0.0055807983981608 no 89 0.00183886735704167 70 17169793 SGTC_2418 pentamidine 31.67 µM 2.89627872449153 0.00569746044755364 no 90 0.00188808421660072 100 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_958 1222-0007 33 µM 2.89532904828458 0.00571098161431974 no 91 0.00189380635603156 84 7312461 SGTC_767 0929-0023 86 µM 2.89010795038303 0.00578582781039286 no 92 0.00192554778267443 172 1204563 SGTC_137 0438-0332 85.389 µM 2.88794640519413 0.00581706819842156 no 93 0.00193882968644713 200 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3317 9138495 8.753 µM 2.86535544881863 0.00615263544435511 no 94 0.00208270698277207 81 17020139 SGTC_1119 parthenolide 318.541 nM 2.8611887594835 0.00621636754408796 no 95 0.00211027841514692 122 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3112 9123419 49.47 µM 2.85155090064065 0.00636602973243551 no 96 0.00217532600293759 71 17015854 SGTC_301 4119-0100 24.5 µM 2.83406871247364 0.00664565848954877 no 97 0.00229797243354503 147 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2398 5228213 48.84 µM 2.79864655803101 0.00724572182473451 no 98 0.00256586375658165 126 80771 YMR134W ERG29 SGTC_278 4092-0821 23.9 µM 2.79785512515262 0.00725965780965235 no 99 0.00257215905348607 99 877900 SGTC_2789 5281112 71.43 µM 2.7972144428716 0.0072709565999263 no 100 0.00257726545434041 108 765948 SGTC_1902 st060212 70.5 µM 2.7805003281811 0.00757124940541525 no 101 0.00271376024246118 80 688944 SGTC_1860 st056228 74.6 µM 2.77625974316016 0.00764915338948981 no 102 0.00274941295405438 76 688679 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.77123868185339 0.00774230732137229 no 103 0.00279217379520156 141 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2845 9003024 42.97 µM 2.75016766708401 0.00814420345927535 no 104 0.00297823889540552 134 2990173 SGTC_2843 9000894 45.46 µM 2.74949402533709 0.00815734906548867 no 105 0.00298436754962816 38 2242070 SGTC_2619 obliquin 87.91 µM 2.74736284496934 0.00819906030047851 no 106 0.00300383150950327 243 6708593 A bioactive alkalod. YER133W GLC7 SGTC_974 1326-0144 138 µM 2.74510496719152 0.00824345554482816 no 107 0.00302457729541926 112 5411856 SGTC_1377 2944-0135 198 µM 2.74016138668268 0.00834139600426275 no 108 0.00307045112915945 118 1894137 SGTC_1191 1487-1166 10.6 µM 2.72004749230547 0.00875049814796294 no 109 0.00326362704231864 98 3955771 SGTC_2488 5268135 45.7 µM 2.71631652965127 0.00882828776835688 no 110 0.00330063859184598 134 1270356 YLR208W SEC13 SGTC_1155 4088-0394 48.2 µM 2.71417459920202 0.00887321978635782 no 111 0.00332205690322112 92 2326248 SGTC_1010 4112-3296 15.2 µM 2.6990989714651 0.00919517376899238 no 112 0.00347637479201606 93 704384 SGTC_724 3910-0327 137 µM 2.68320244988586 0.00954568954385295 no 113 0.00364604162580773 91 2885483 SGTC_1491 4138-0063 26.5 µM 2.67564486646974 0.00971639132962439 no 114 0.00372928157297582 45 23883227 SGTC_2368 9071271 200 µM 2.65919536258063 0.0100971784036179 no 115 0.00391637647259845 111 27209959 SGTC_799 1310-0557 151 µM 2.65270356059825 0.0102510022416146 no 116 0.00399249820132271 109 5354492 SGTC_3152 9099253 49.47 µM 2.64976863202203 0.0103212138652098 no 117 0.00402734549954371 253 25236131 SGTC_1746 st038117 42 µM 2.64750129252042 0.0103757416336531 no 118 0.00405445248799249 119 2898218 SGTC_2776 terbinafine 19.92 µM 2.64385559940915 0.0104639443160988 no 119 0.00409838081393942 130 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1152 3909-8331 15.9 µM 2.64238171146951 0.01049978813422 no 120 0.00411626081699158 76 16001939 SGTC_1903 st060211 78.3 µM 2.63478018800056 0.0106863551190618 no 121 0.00420958927427519 111 688960 SGTC_77 0828-0286 12.516 µM 2.63390185499283 0.010708097320983 no 122 0.00422049416250942 136 745345 SGTC_973 1325-0077 65.9 µM 2.63371723578819 0.0107126722696823 no 123 0.00422278950132566 78 2835149 SGTC_2900 5328528 85.29 µM 2.63343052855718 0.0107197803805423 no 124 0.00422635629615204 123 795359 SGTC_3284 9108171 64.8615 µM 2.63241437972928 0.0107450060549217 no 125 0.00423901944992425 89 8687505 SGTC_1708 st033234 31.827 µM 2.6279427797148 0.0108566276692464 no 126 0.00429514820700666 77 674664 SGTC_70 0141-0289 43.283 µM 2.61951167845984 0.011069835281272 no 127 0.00440278787970674 347 352408 SGTC_2243 6634756 200 µM 2.61172709673601 0.0112699177452721 no 128 0.00450430669770482 85 885676 SGTC_3114 9122766 49.47 µM 2.60320234649435 0.0114926231390532 no 129 0.00461787130392974 107 17176985 SGTC_2898 9056270 58.44 µM 2.59727888430765 0.0116496129001274 no 130 0.00469827986458647 55 19154699 SGTC_411 enrofloxacin 100 µM 2.59040775528729 0.0118340480218525 no 131 0.00479311546431816 70 71188 A bacterial gyrase inhibitor. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.58223930026034 0.012056597535456 no 132 0.00490807470708165 143 91467 include heat shock SGTC_2443 5493264 126.67 µM 2.57432961927381 0.0122755457974891 no 133 0.00502172697899217 103 5340055 SGTC_445 e6 berbamine 66 µM 2.56174560218137 0.0126309854705521 no 134 0.00520737872771438 249 6610268 A calcium/calmodulin antagonist. SGTC_1683 st010134 710 nM 2.5594662550834 0.0126963104114511 no 135 0.00524165165084142 130 3818134 SGTC_2854 9024559 71.43 µM 2.55125437318666 0.0129340885863972 no 136 0.00536679767304971 115 3163529 SGTC_262 fenpropimorph 62.5 µM 2.54971098545498 0.0129792052667262 no 137 0.0053906126857971 99 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2825 7998094 58.44 µM 2.54948469455543 0.0129858316808987 no 138 0.00539411231927842 110 2987815 SGTC_2358 9037157 4 µM 2.5462608203877 0.0130805536371354 no 139 0.00544418998545811 117 2388925 SGTC_1697 st025554 27.742 µM 2.52462515768963 0.0137318246976445 no 140 0.00579108772846378 90 1269519 SGTC_994 3910-0338 138 µM 2.51922595382238 0.0138986460349081 no 141 0.00588065773475211 138 3479481 SGTC_2727 riluzole 51.77 µM 2.51881380427912 0.0139114518683329 no 142 0.00588754529678955 72 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1106 tegaserod maleate 11.7 µM 2.5094797921258 0.0142042036494001 no 143 0.00604545667046733 132 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2158 5657123 3.6195 µM 2.49875290772931 0.0145471814769192 no 144 0.00623155883947489 70 2858827 SGTC_1740 st038286 13.222 µM 2.4908392356586 0.0148047576136676 no 145 0.00637208849855918 130 716786 SGTC_538 2922-0838 53.3 µM 2.48522224169126 0.0149899522991494 no 146 0.00647352892861835 149 777039 SGTC_2896 9052656 71.43 µM 2.48213388841718 0.0150926224895907 no 147 0.0065299097166253 289 6469436 SGTC_3095 9117207 49.47 µM 2.47615716907604 0.0152930315583665 no 148 0.00664025506088222 74 17015229 SGTC_2514 salinomycin 42.74 µM 2.47425815703037 0.0153571851045661 no 149 0.00667565906071801 163 23682228 A polyether potassium ionophore. SGTC_2030 5175110 200 µM 2.46747381545894 0.0155882687232717 no 150 0.0068035086414374 116 2831986 SGTC_2847 9005661 71.43 µM 2.45006523202469 0.0161949225449254 no 151 0.00714151680788034 53 2991449 SGTC_3117 9124945 49.47 µM 2.45001018859721 0.0161968723271561 no 152 0.00714260862298037 77 17592065 SGTC_3282 9108498 15.4605 µM 2.44669408697079 0.016314708925796 no 153 0.00720865748640167 134 16459645 SGTC_1982 st072467 71.9 µM 2.43753354449215 0.0166440483141714 no 154 0.00739392106437364 166 3163533 SGTC_2827 7993847 71.43 µM 2.42197942454646 0.0172162820198276 no 155 0.00771811225654447 117 2985692 SGTC_1060 3448-7350 82 µM 2.42189184943805 0.0172195508940259 no 156 0.00771997243450424 119 570178 SGTC_221 trifluoperazine 10.304 µM 2.41775137192519 0.0173747068888137 no 157 0.00780837164361123 361 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2250 alverine citrate 130 µM 2.40834495554959 0.0177316359342133 no 158 0.0080125156901457 347 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1739 st037196 92.5 µM 2.40721460858684 0.0177749454148544 no 159 0.00803736027695033 142 612214 SGTC_3224 9130643 49.47 µM 2.40009400151457 0.0180498530581944 no 160 0.00819543104227695 151 17644395 SGTC_3342 9147791 14.508 µM 2.39063089084725 0.0184208015014654 no 161 0.00840972633821239 109 1838168 SGTC_806 3966-4455 5.86 µM 2.39035686813473 0.0184316390547511 no 162 0.00841600427872583 116 714982 SGTC_1194 1488-0194 225 µM 2.38071544956742 0.0188164274000974 no 163 0.00863952671241763 156 1391452 SGTC_404 fumagillin 50 µM 2.36486560409674 0.019463844543132 no 164 0.00901830745375863 140 12015870 A methionine aminopeptidase binder. SGTC_158 k038-0087 26.446 µM 2.3595288504208 0.0196860502930501 no 165 0.00914907899658579 296 X158 SGTC_2473 5854593 8.94 µM 2.35731720375834 0.0197787655726301 no 166 0.00920375776141068 93 2872951 SGTC_2478 5763493 32.33 µM 2.35650158240455 0.0198130509655883 no 167 0.00922399452377743 125 1365576 YLR208W SEC13 SGTC_3137 9097352 49.47 µM 2.34305105552881 0.0203857714947841 no 168 0.00956338277380814 194 44120435 SGTC_2873 9040596 71.43 µM 2.3395434444651 0.0205374109342841 no 169 0.00965366294371634 169 6463863 SGTC_14 0354-0009 295 µM 2.3226841290242 0.0212796662625038 no 170 0.0100980637464049 144 1713507 SGTC_3238 9133470 49.47 µM 2.31730383730341 0.0215212656646374 no 171 0.0102435932131206 100 3534688 SGTC_2168 5727979 200 µM 2.31729730306542 0.0215215604851196 no 172 0.0102437710615229 118 695210 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.3139457091871 0.0216732327685638 no 173 0.0103353501839773 133 66535 A nucleotide analog. SGTC_740 k014-0057 261 µM 2.31334672756361 0.0217004338514506 no 174 0.0103517917565275 160 4012779 SGTC_3090 9117696 49.47 µM 2.31302548064126 0.0217150342645837 no 175 0.0103606191216135 117 7923821 SGTC_2807 7945238 51.95 µM 2.30446054170928 0.0221073749546704 no 176 0.0105984024413241 176 17148797 SGTC_2061 5245884 80.95 µM 2.30226313013318 0.0222089924499849 no 177 0.0106601688612427 153 573863 SGTC_2156 5649887 115 µM 2.29126366834568 0.022723596630955 no 178 0.0109740842805377 152 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_600 1495-0418 41.6 µM 2.28540083113127 0.0230019681029725 no 179 0.0111446676629075 137 5377768 SGTC_723 4182-0001 115 µM 2.27250654488164 0.0236243138249765 no 180 0.0115279665726516 151 744821 YLR208W SEC13 SGTC_1936 st074407 74.3 µM 2.26971020006938 0.023761132538411 no 181 0.0116125860628698 213 809813 SGTC_2921 7974240 10.71 µM 2.26274093635468 0.0241050243053183 no 182 0.0118258318723567 198 2979074 YDR527W RBA50 SGTC_2951 9072950 58.06 µM 2.26005392443939 0.0242387245678418 no 183 0.0119089521409625 175 16488155 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.24305841426617 0.0250988900374104 no 184 0.0124465239407541 178 4174840 SGTC_2681 menadione 3.18 µM 2.23063548364007 0.0257436940084286 no 185 0.0128526421860403 149 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3189 9110682 49.47 µM 2.22641649624109 0.0259658077303846 no 186 0.0129931482699838 163 17122418 SGTC_1839 st053978 48 µM 2.22213640920101 0.0261927740075894 no 187 0.0131370441864067 163 3788398 SGTC_2280 7785178 200 µM 2.21812171698655 0.0264071722111355 no 188 0.0132732672262857 140 2954328 SGTC_2290 7904846 200 µM 2.21427608711677 0.0266139152910546 no 189 0.0134048962808879 202 2962154 SGTC_908 3448-7491 47.7 µM 2.20975350048186 0.0268587802593903 no 190 0.0135611372413787 327 1203031 SGTC_3166 9102297 49.47 µM 2.20938136981007 0.0268790118949403 no 191 0.0135740628747766 191 25237072 SGTC_3065 9113888 49.47 µM 2.19451459020119 0.0276977427033029 no 192 0.014099218108121 156 16648368 SGTC_2445 5742597 35.57 µM 2.19247901622441 0.027811445193195 no 193 0.0141724683186902 163 1774255 SGTC_1911 st060208 74.3 µM 2.1842385244822 0.028275721199111 no 194 0.0144723627244168 192 688783 SGTC_1335 1486-0900 202 µM 2.1765712484856 0.0287134776879967 no 195 0.0147562861600121 206 X1335 SGTC_2028 5153890 36.43 µM 2.1745090482606 0.0288321742717076 no 196 0.0148334633094791 181 2830968 YPR165W RHO1 SGTC_883 0850-0245 24.6 µM 2.17114897331959 0.0290264478386023 no 197 0.0149599565432594 196 6823229 YPR165W RHO1 SGTC_513 4245-1575 41.7 µM 2.16859948564645 0.029174579431577 no 198 0.0150565521335207 340 719745 SGTC_2957 9076800 11.52 µM 2.16073460655241 0.0296355102577972 no 199 0.0153579230234766 169 16459615 SGTC_542 3381-0244 89.3 µM 2.15907116577382 0.0297337685454621 no 200 0.0154223231208345 204 1112843 SGTC_265 mycophenolic acid 32.932 µM 2.15353856431939 0.0300625219599797 no 201 0.015638188333119 195 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1048 3161-0300 24.5 µM 2.15210487132932 0.0301482035816565 no 202 0.0156945477876428 182 2165101 SGTC_879 0831-1030 162 µM 2.1486121493018 0.0303577863093007 no 203 0.0158325788996687 243 1549252 SGTC_2484 5809818 12.04 µM 2.14789872774511 0.0304007437119876 no 204 0.0158609007419265 167 2870548 SGTC_418 lividomycin a 100 µM 2.12894788064847 0.0315604001695338 no 205 0.0166292863694717 156 72394 An antibiotic. SGTC_3264 9137442 49.47 µM 2.12799016915581 0.0316199627846291 no 206 0.016668949338545 134 17015726 SGTC_3298 9116858 71.43 µM 2.12415934893132 0.0318591413450844 no 207 0.0168284105805443 169 2506942 SGTC_140 0062-0056 502.533 µM 2.12263506650382 0.031954725137973 no 208 0.0168922220530851 212 3758964 SGTC_2513 baicalein 25.65 µM 2.11879263638496 0.0321967253088601 no 209 0.017053997668868 184 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2325 6158266 200 µM 2.1171709970837 0.0322993107750921 no 210 0.0171226689577507 189 3623240 SGTC_1984 st072354 53.1 µM 2.11142358575706 0.0326650684135535 no 211 0.017367959784181 153 5762938 SGTC_522 1273-0010 11.6 µM 2.10346109173958 0.0331774282760573 no 212 0.0177127414971343 194 5705015 SGTC_3182 9108849 49.47 µM 2.10138343790677 0.0333122020188026 no 213 0.0178036603119291 204 17133045 SGTC_3307 9126885 69.2785 µM 2.09830151195227 0.0335129512934404 no 214 0.0179392595283338 222 24824909 SGTC_591 4299-0174 154 µM 2.08919310774645 0.0341120788554851 no 215 0.0183451718055908 149 5509088 SGTC_3011 9081274 71.4286 µM 2.08724672561027 0.0342412422510691 no 216 0.0184329188693732 223 6625322 SGTC_2346 9031566 143.75 µM 2.08665574341679 0.0342805397458237 no 217 0.0184596322523653 174 4771086 SGTC_1016 4226-1401 38 µM 2.0786014761975 0.0348198147051969 no 218 0.0188269975974576 207 2901613 SGTC_1093 fluphenazine 7.97 µM 2.0686729063859 0.0354941485774571 no 219 0.0192883956568938 203 6602611 An atypical antipsychotic. SGTC_2643 anethole 100 µM 2.06787448514941 0.0355488381622432 no 220 0.0193259136200961 206 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 2.06168392022961 0.0359752225395085 no 221 0.0196189192209871 267 368090 SGTC_2629 bisabolol 100 µM 2.04839383121293 0.0369047531252427 no 222 0.0202607127503465 237 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_3047 9092122 49.47 µM 2.03739207854826 0.0376890078662048 no 223 0.0208053835259683 210 17173831 SGTC_1751 st044839 27.194 µM 2.03193719220898 0.0380828724410744 no 224 0.0210800073730159 159 5291326 SGTC_541 4513-1321 94 µM 2.02845678303867 0.0383359217350423 no 225 0.0212568249003208 209 747515 SGTC_3119 9125183 49.47 µM 2.02262153242279 0.0387632585928952 no 226 0.021556091233524 122 22695334 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.00750834724944 0.0398881139590392 no 227 0.0223477813665997 221 390807 SGTC_527 4476-4215 268 µM 2.00688093403387 0.0399353791752605 no 228 0.0223811712083106 244 4418754 SGTC_1844 rapamycin 4 nM 2.0053577627457 0.0400503143633592 no 229 0.0224624068553155 397 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2875 9039966 71.43 µM 2.00284776362813 0.0402402997099131 no 230 0.0225968156679953 150 6463691 SGTC_687 k029-0044 34.9 µM 2.00095101189596 0.040384352567068 no 231 0.0226988347042408 196 5829338 SGTC_3205 9113483 49.47 µM 2.00000019878661 0.0404567215088251 no 232 0.0227501212154999 262 17018033 SGTC_2021 4019055 173 µM 1.9995068244077 0.0404943150320585 no 233 0.0227767721101065 401 44827708 YER133W GLC7 SGTC_2296 7971656 126.45 µM 1.99757470285524 0.0406418094984051 no 234 0.0228813940488146 255 666570 SGTC_1234 0326-0494 15.5 µM 1.99492004585676 0.0408451717216838 no 235 0.0230258004114458 192 1547813 SGTC_1737 st035557 69.7 µM 1.99384917965224 0.040927439659828 no 236 0.0230842695900637 188 5716916 SGTC_2667 digitoxin 100 µM 1.98771362746783 0.0414013903816898 no 237 0.0234216854498931 118 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3208 9114115 49.47 µM 1.97715137691907 0.0422277008593882 no 238 0.0240122609163588 251 650895 SGTC_2052 5265182 7.135 µM 1.97407953090096 0.042470507925523 no 239 0.0241863502128924 241 1239884 SGTC_941 3237-0776 460 µM 1.97377920986893 0.0424943065863977 no 240 0.024203426911971 209 760008 SGTC_1446 4239-0190 62 µM 1.96773185059685 0.042975823193707 no 241 0.0245494495334681 272 1340085 SGTC_2476 5806916 10.51 µM 1.95985218247573 0.0436098402877755 no 242 0.025006534995414 196 2870194 SGTC_2307 7538926 6.34 µM 1.94976371235977 0.0444325785959607 no 243 0.0256021442585738 289 96582 SGTC_3010 9080089 71.4286 µM 1.94970862607729 0.0444371051058913 no 244 0.0256054287986363 228 17027233 SGTC_2797 7859098 81.82 µM 1.9480315902132 0.0445750872064392 no 245 0.0257055916718256 254 972681 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.93919070713666 0.0453082071493452 no 246 0.0262390603773581 252 6710655 SGTC_1070 indatraline 8.81 µM 1.93522562595427 0.0456401424246295 no 247 0.0264813072009126 256 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1268 0828-0275 2.46 µM 1.93257903476926 0.0458627867332378 no 248 0.0266440385865232 236 745337 SGTC_2739 tacrine 100.86 µM 1.92960903806605 0.0461136759007622 no 249 0.0268276490565535 215 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1282 0886-0010 32.4 µM 1.92899270976972 0.0461658778289761 no 250 0.026865883636831 263 2836211 YNL267W PIK1 SGTC_1198 1612-1005 86.7 µM 1.92666302369774 0.0463636270516385 no 251 0.0270108194162377 216 6998509 SGTC_1681 tripelennamine 100 µM 1.92445964759571 0.0465512799643348 no 252 0.0271484970328612 199 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_860 0443-0016 25.1 µM 1.91766490190612 0.0471338024904385 no 253 0.0275767574280124 242 5337942 SGTC_59 0330-0160 1.33 µM 1.91672574930569 0.0472147749773076 no 254 0.0276363911122763 433 4293482 SGTC_2821 7996764 71.43 µM 1.90088359961473 0.048597540736541 no 255 0.0286586303556207 303 2987135 SGTC_1067 clotrimazole 1.36 µM 1.89739256122306 0.0489065640717829 no 256 0.0288880733413929 272 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_232 clozapine 119 µM 1.89296894146475 0.0493003916761078 no 257 0.0291809999601054 285 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2123 5259487 200 µM 1.8917037034304 0.0494134982385328 no 258 0.0292652348170229 253 2173474 SGTC_356 1634-0012 32.5 µM 1.88689170328479 0.0498455625627832 no 259 0.0295874466343963 265 735457 SGTC_1123 mangostin 811.285 nM 1.87690825908967 0.0507515748567819 no 260 0.0302653343556523 296 5281650 An antioxidant. SGTC_927 2425-1185 123 µM 1.87503770494163 0.0509227802270865 no 261 0.0303937682744236 261 730375 SGTC_3003 9075612 71.4286 µM 1.87198414853534 0.0512032492543328 no 262 0.0306043982809803 247 6501993 SGTC_546 peri-Naphthalide 147 µM 1.86673141362134 0.0516885870365944 no 263 0.0309695522996938 254 223824 A penicillin ester. SGTC_275 trichlorophene 5.69 µM 1.86576519536503 0.0517782598024432 no 264 0.0310371118842907 493 62616 SGTC_2407 paclitaxel 400 µM 1.85865130183624 0.0524422980949446 no 265 0.0315382901591905 306 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2400 5203494 178.7 µM 1.85399497130262 0.0528805864076851 no 266 0.0318699397162944 248 6777674 SGTC_1704 st028805 70.8 µM 1.85135126781651 0.0531307215356423 no 267 0.0320595174945983 240 2876101 SGTC_2289 7946404 165.07 µM 1.85122361673006 0.0531428229985199 no 268 0.0320686947623175 367 1246120 YPR165W RHO1 SGTC_3310 9130229 44.1445 µM 1.85006762217932 0.0532525120776498 no 269 0.0321519019165698 261 7761258 SGTC_2020 4017018 200 µM 1.84598826096432 0.0536410259225987 no 270 0.0324469549738131 259 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_562 3772-2733 112 µM 1.8447725097145 0.0537572459927139 no 271 0.0325353189792974 341 2876874 YIL048W NEO1 SGTC_1382 3002-2117 298 µM 1.8372806162879 0.054477842443593 no 272 0.0330842399558496 269 1497314 SGTC_2422 chlorphenesin carbamate 384.24 µM 1.83677915149948 0.0545263465681213 no 273 0.0331212524482063 336 2724 A muscle relaxant with antifungal properties. SGTC_2191 5911152 200 µM 1.83329917880411 0.0548638880454999 no 274 0.033379045727088 264 2875902 SGTC_2745 rifampicin 24.3 µM 1.83105497496455 0.0550824400753167 no 275 0.0335461689899249 142 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.8251934319907 0.0556565120626913 no 276 0.0339859223049131 270 75037 A free radical scavenger. SGTC_1230 0170-0365 3.77 µM 1.82513871009809 0.0556618936171291 no 277 0.0339900499610876 419 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1068 loratadine 26.9 µM 1.82004053471963 0.0561650710957593 no 278 0.0343764161134857 275 3957 A H1 histamine antagonist. SGTC_133 0724-0033 378.92 µM 1.80186898597795 0.0579877847553758 no 279 0.0357830103850225 257 280309 SGTC_326 k292-0812 17.5 µM 1.80067660423225 0.0581089943914022 no 280 0.0358769336211203 225 3579357 SGTC_625 k213-0058 121 µM 1.79822144581742 0.0583591964533814 no 281 0.03607096117856 466 3655420 SGTC_1557 sumaresinolic acid 42.3 µM 1.79151077363788 0.059047390519232 no 282 0.0366056836461103 271 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1555 citronellol 128 µM 1.78824339139797 0.0593847641280662 no 283 0.0368683742337688 219 8842 A terpine precursor. SGTC_2252 omeprazole 400 µM 1.78655704485305 0.0595594781398574 no 284 0.0370045547889786 172 4594 A proton pump inhibitor. SGTC_1014 4130-3005 69.3 µM 1.7822980210403 0.0600025281289722 no 285 0.0373503226294334 325 743608 SGTC_766 1391-0721 126 µM 1.78195144442655 0.0600386944264983 no 286 0.0373785751053798 279 1020919 YIL115C NUP159 SGTC_2689 tacrolimus 100 µM 1.77176934741514 0.0611088628732346 no 287 0.0382164263852254 317 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_324 1315-0088 19.6 µM 1.76993897578646 0.0613028116653995 no 288 0.0383686535385597 231 6787421 SGTC_2673 kobusone 100 µM 1.76934355412627 0.061366006959988 no 289 0.0384182796046703 206 6710676 An epoxy ketone and protein crosslinker. SGTC_926 2268-1401 59.4 µM 1.76375814341088 0.0619612970955566 no 290 0.0388863536596748 312 2931578 SGTC_830 4076-0286 57.8 µM 1.75774622549565 0.0626070697836905 no 291 0.039395349375389 494 6866659 SGTC_39 0986-0283 58.349 µM 1.75566627733704 0.062831705756157 no 292 0.0395727040722739 352 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3044 9093193 49.47 µM 1.75203701742655 0.0632251719119833 no 293 0.0398837214634141 343 25236277 SGTC_737 1950-0117 57.9 µM 1.74779958262196 0.0636869980720219 no 294 0.0402493688145764 302 5393513 SGTC_126 0417-1624 672.48 µM 1.74570121295084 0.0639166630225396 no 295 0.0404314421125536 388 41912 YDL195W SEC31 SGTC_1596 piperlongumine 63 µM 1.74173211758743 0.0643528382312155 no 296 0.0407776648720274 309 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_667 1498-1044 59 µM 1.74171415741349 0.0643548171695837 no 297 0.0407792369817205 312 6739982 SGTC_3101 9120531 49.47 µM 1.73047277905585 0.0656027501226289 no 298 0.0417729202890708 327 24824904 SGTC_3191 9110352 49.47 µM 1.72429513737645 0.0662964896178584 no 299 0.0423272883434151 262 17122424 SGTC_1558 st069300 45.6 µM 1.72362063495826 0.0663725779221584 no 300 0.0423881754457727 209 24208000 SGTC_467 ro 31-8220 72.8 µM 1.72328257451827 0.066410738790178 no 301 0.0424187186879337 381 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_43 0570-0105 72.5 µM 1.71800460123561 0.0670087312433745 no 302 0.042897888006923 472 1114046 YDL195W SEC31 SGTC_1241 0364-0022 50.8 µM 1.71245987566728 0.06764142355919 no 303 0.0434059764563318 341 4563895 SGTC_281 1672-3440 14.9 µM 1.7099051290062 0.0679344869042996 no 304 0.0436417089254415 320 6833000 SGTC_399 oxolinic acid 75 µM 1.70841376720684 0.0681060185736149 no 305 0.0437797972586577 278 4628 A DNA gyrase inhibitor. SGTC_1757 st041620 31.8375 µM 1.70236311329575 0.0688053771480795 no 306 0.0443436601612492 334 5289815 SGTC_178 4092-0806 87.505 µM 1.69711499007632 0.0694164487884544 no 307 0.0448374613688898 459 2169044 SGTC_2318 6029776 164 µM 1.69603706023869 0.0695424747263829 no 308 0.0449394309064014 346 818325 SGTC_1492 4158-0558 28.5 µM 1.69556282771341 0.0695979752952353 no 309 0.0449843512383874 308 3967268 SGTC_1062 mesoridazine 14.2 µM 1.69278066062842 0.0699242661467569 no 310 0.0452486125817833 343 4078 A neuroleptic. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.69129238164784 0.0700992931889107 no 311 0.0453904871761394 342 5393153 SGTC_1187 1391-0724 117 µM 1.68822629066125 0.0704609388214627 no 312 0.0456838991341154 360 6997986 SGTC_3248 9135562 49.47 µM 1.68555420976033 0.0707772791428514 no 313 0.0459408475810589 339 17650701 SGTC_2064 5220758 200 µM 1.6793621320133 0.0715145356174819 no 314 0.0465407443653624 383 788518 SGTC_875 0709-0210 25.7 µM 1.67929001822446 0.071523156391013 no 315 0.0465477677040817 379 6251364 SGTC_1288 0973-0013 65.5 µM 1.67897561163829 0.0715607511414842 no 316 0.0465783984715896 332 4315430 SGTC_2265 7929201 200 µM 1.67073753068505 0.0725512213505912 no 317 0.0473867661528133 339 1265108 SGTC_2906 7926292 26.41 µM 1.67055408451595 0.0725733961290827 no 318 0.0474048940862091 345 2966319 SGTC_3026 9090633 49.47 µM 1.66734014014416 0.0729627370129643 no 319 0.0477233946488001 327 25236842 SGTC_1564 D-Arginine 115 µM 1.65379881257182 0.0746207257259696 no 320 0.049084198663488 355 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2846 9008642 19.48 µM 1.65317949189412 0.0746972368476571 no 321 0.0491471694871376 320 2992898 SGTC_2442 5158906 48.48 µM 1.65147746353864 0.0749078144360996 no 322 0.0493205594096374 356 1893835 SGTC_2483 5729050 27.16 µM 1.65106580775107 0.0749588130716153 no 323 0.0493625690869838 428 2865180 SGTC_2532 xanthone 78.9 µM 1.64745449674797 0.0754073419620938 no 324 0.0497323308892721 341 7020 An insecticide. SGTC_1258 0671-0043 57.1 µM 1.64453382365062 0.0757715866456186 no 325 0.0500329917942346 370 4298767 SGTC_1986 st071812 45 µM 1.63838803695556 0.0765424184442118 no 326 0.0506703865512174 291 11838594 SGTC_1812 st052057 4.327 µM 1.63751943947352 0.0766518411712245 no 327 0.0507609902571606 358 3645418 SGTC_2994 9053520 71.4286 µM 1.63366723479177 0.0771385619751345 no 328 0.0511643708955568 351 4647384 SGTC_208 k072-0098 12.366 µM 1.63322683907136 0.0771943546239261 no 329 0.0512106486118815 440 5948901 SGTC_918 glabranin 770.725 nM 1.63106211891629 0.07746904352089 no 330 0.0514386063756054 373 124049 Also referred to as licorice root. SGTC_505 gw-5074 63.9 µM 1.62968161079526 0.0776446082653613 no 331 0.0515844029470215 369 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_90 0870-0863 4.608 µM 1.62927572201778 0.0776962841848231 no 332 0.05162733163376 396 1738164 SGTC_526 4469-0568 170 µM 1.62755472339865 0.0779156840048644 no 333 0.051809668081729 360 2901964 SGTC_402 epigallocatechin gallate 10 µM 1.62640473338656 0.0780625511773231 no 334 0.0519317922836533 380 65064 An antioxidant. SGTC_1271 0832-2808 169 µM 1.62499410402714 0.0782429917438264 no 335 0.0520819075649657 360 3663794 SGTC_211 3455-0679 143.504 µM 1.61967390499864 0.0789263716136172 no 336 0.0526511722907575 393 748649 SGTC_2774 tamoxifen 10.92 µM 1.619327583636 0.0789710128601049 no 337 0.0526883994016111 354 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1484 3473-2379 286 µM 1.6147320868571 0.0795651899849605 no 338 0.0531843628769305 420 671917 SGTC_2770 toltrazuril 17.5 µM 1.61283181758608 0.0798118725298563 no 339 0.0533905257474961 370 68591 Kills coccidiodes. SGTC_56 0957-0365 83.25 µM 1.61204840933341 0.0799137385269366 no 340 0.0534757029569667 388 6752360 SGTC_1840 st055363 71 µM 1.6114646540248 0.0799897077025006 no 341 0.0535392425887444 321 676033 SGTC_1870 st057514 26.5 µM 1.61032500666654 0.080138177308741 no 342 0.0536634614021306 355 5393161 SGTC_148 3253-0744 288.01 µM 1.60950111618547 0.0802456407867799 no 343 0.0537534055671278 350 6893655 SGTC_1912 st060209 90.8 µM 1.60806891905593 0.0804327074062668 no 344 0.0539100427171871 369 688787 SGTC_89 0302-0250 142.109 µM 1.60625276539563 0.0806703981320186 no 345 0.0541091920318364 391 4203518 YLR208W SEC13 SGTC_230 MPP+ 141.667 µM 1.60403153319761 0.0809618245511358 no 346 0.0543535510417938 351 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_48 0382-0018 55 µM 1.60396420589687 0.0809706703083471 no 347 0.054360971365602 319 762596 SGTC_1960 st011366 51.8 µM 1.60149691498452 0.0812953372941631 no 348 0.0546334513803653 324 3972846 SGTC_605 1315-0399 119 µM 1.60131783863311 0.0813189398451526 no 349 0.0546532699812386 403 24020461 SGTC_3251 9135047 49.47 µM 1.60094440113462 0.0813681761370412 no 350 0.0546946170567974 279 17682963 SGTC_2330 7979373 200 µM 1.596915381279 0.0819008177163987 no 351 0.0551422853469868 397 1863007 SGTC_427 1354-0053 47.3 µM 1.59365622713844 0.082333601114612 no 352 0.0555065267076398 387 6813657 SGTC_2135 5326629 150.42 µM 1.59282519565152 0.0824442289202192 no 353 0.055599705599456 359 5020077 SGTC_2737 bleomycin 30.5 nM 1.59149787215008 0.0826211557208628 no 354 0.0557487869588512 435 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2086 5274770 176.623 µM 1.58930852217254 0.0829136113398064 no 355 0.0559953778302789 367 689278 SGTC_2614 arthonioic acid 13.39 µM 1.58864565003946 0.0830023118888363 no 356 0.056070207878245 344 6710684 SGTC_2800 7887935 81.82 µM 1.58543695513525 0.0834326844021892 no 357 0.0564335451883714 366 2961002 SGTC_2115 tiliquinol 12.7705 µM 1.58468326582906 0.0835340172814742 no 358 0.056519157915028 324 71208 A bioactive hydroxyquinoline. SGTC_805 3852-0218 479 µM 1.58443133406692 0.0835679099062701 no 359 0.0565477980432211 393 6615355 SGTC_1183 1254-0324 198 µM 1.58345571773103 0.0836992580120642 no 360 0.0566588160477002 371 5799357 SGTC_3236 9132701 49.47 µM 1.58166530177084 0.0839407067043997 no 361 0.0568629989222324 357 24282524 SGTC_1791 st048313 56.1 µM 1.58122342339232 0.0840003771372051 no 362 0.0569134807298174 326 1204976 SGTC_1338 1486-1223 76 µM 1.57625648393056 0.0846732959689926 no 363 0.057483352976571 393 3444526 SGTC_161 4065-0411 162.148 µM 1.57497842492767 0.0848470990825992 no 364 0.057630712330526 462 1906281 YLR208W SEC13 SGTC_1873 rapamycin 2 nM 1.57435490072721 0.0849319890920791 no 365 0.0577027119993616 443 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2302 7771753 200 µM 1.56975504573496 0.0855602069794962 no 366 0.0582360548173263 447 2203047 SGTC_376 3970-0862 59.1 µM 1.56846007517347 0.0857376916643752 no 367 0.0583869002280332 393 3135186 SGTC_1037 k284-1091 78.7 µM 1.56716805571899 0.0859150464061277 no 368 0.0585377075243068 317 3334711 SGTC_2103 5378138 10 µM 1.56698443298416 0.0859402744561474 no 369 0.0585591651649607 418 244142 SGTC_3017 9080681 49.47 µM 1.56594310268409 0.0860834483913787 no 370 0.0586809689552729 365 16451914 SGTC_1665 st014639 11.4 µM 1.56362565326628 0.0864027180564654 no 371 0.0589527533776272 429 981133 YIL048W NEO1 SGTC_2066 5222451 176 µM 1.56216675941914 0.0866041601391332 no 372 0.0591243545651688 454 2281147 SGTC_1813 st051246 8.6015 µM 1.5555743640155 0.0875188078928861 no 373 0.0599046693389791 333 5291959 SGTC_581 0958-0271 211 µM 1.55334535915248 0.0878296915688365 no 374 0.0601703246232239 480 4591145 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.55220871010049 0.0879885389992164 no 375 0.0603061463329579 431 165506 SGTC_2262 9014885 67.46 µM 1.55106918493 0.0881480033079751 no 376 0.0604425524742773 277 6457424 SGTC_2786 7743617 45.45 µM 1.55079264246523 0.088186734921877 no 377 0.0604756921925402 326 583674 SGTC_1784 st039334 36.3 µM 1.54729332033072 0.0886779346839286 no 378 0.0608962658601672 401 3496984 SGTC_3244 9134489 49.47 µM 1.54276096637171 0.0893171661774231 no 379 0.0614443917236548 386 16584271 SGTC_3089 9117425 49.47 µM 1.53974309974319 0.0897446954923933 no 380 0.0618114932764519 389 9401657 SGTC_2688 kanamycin b 96.69 µM 1.53904703582233 0.0898435196931072 no 381 0.0618964068878792 946 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3105 9121040 49.47 µM 1.53440313256299 0.0905049121519727 no 382 0.0624652537195793 191 41448907 SGTC_2940 9060638 45.86 µM 1.53357902162895 0.0906226601051156 no 383 0.0625666262693629 411 4027022 SGTC_1529 apigenin 74 µM 1.52875178408285 0.0913146543811133 no 384 0.0631629947148123 442 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2552 juarezic acid 87.02 µM 1.5278704723023 0.0914414139903146 no 385 0.0632723503757766 484 1549512 SGTC_272 doxorubicin 8.13 µM 1.52206541896771 0.0922796187848074 no 386 0.0639963448732325 470 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3308 9128332 17.569 µM 1.51271627060365 0.093641496589589 no 387 0.0651758724238532 519 17332805 YDL196W YDL196W SGTC_146 3448-8650 53.125 µM 1.50931866925546 0.0941400795231764 no 388 0.0656086829994681 586 2891488 YIL048W NEO1 SGTC_3077 9117319 49.47 µM 1.5084576952771 0.09426673409653 no 389 0.0657187131049263 347 17154678 SGTC_3162 9099653 49.47 µM 1.50706839107984 0.0944713742590613 no 390 0.0658965639402727 349 25237511 SGTC_2338 7999974 200 µM 1.50606641633258 0.0946191651770323 no 391 0.0660250624013159 449 315925 SGTC_1789 tunicamycin 25 nM 1.49934732024684 0.0956146350057544 no 392 0.0668917761687118 413 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2187 6125751 200 µM 1.49816240455494 0.0957909830287981 no 393 0.0670455303921582 438 874498 SGTC_1893 st059353 36.1 µM 1.49791485122769 0.0958278559636729 no 394 0.0670776873108241 447 3112488 SGTC_640 3381-0960 37.1 µM 1.4974287269937 0.0959002942857625 no 395 0.0671408690487057 432 1745025 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.49700062502322 0.0959641199397641 no 396 0.0671965477114658 437 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.49519645420516 0.0962334467279262 no 397 0.0674315893301549 477 6708784 An antioxidant flavonoid SGTC_1076 itraconazole 331 nM 1.49328294895389 0.0965197016647975 no 398 0.0676815684918502 427 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3124 9127567 49.47 µM 1.49257358533148 0.0966259792296409 no 399 0.067774421004498 391 17592030 SGTC_10 0279-0212 42.575 µM 1.49149813538985 0.0967872681203876 no 400 0.0679153801957759 561 39851 YBR002C RER2 SGTC_394 menadione 8.33 µM 1.4898184495412 0.0970395717161345 no 401 0.0681359893489352 441 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_944 3370-0224 231 µM 1.48706097738611 0.0974548145563755 no 402 0.0684993533591456 428 4580514 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.48500329540832 0.0977655253296327 no 403 0.068771475578019 423 641818 YHR062C RPP1 SGTC_282 k297-0036 65.7 µM 1.48270486598451 0.098113447002277 no 404 0.0690764206212931 373 5061378 SGTC_745 0469-0705 296 µM 1.4821659439555 0.0981951567282836 no 405 0.0691480729043773 479 3486736 SGTC_1717 st033143 58.0435 µM 1.47569514025264 0.099180135503848 no 406 0.070012875582902 485 674616 SGTC_1128 3448-9350 235 µM 1.47212728874944 0.0997263105838672 no 407 0.0704932538395747 400 619386 SGTC_2811 7967822 32.47 µM 1.47164630564698 0.0998001083647423 no 408 0.0705582071197958 451 2232244 SGTC_681 1642-0006 26.6 µM 1.47037146684617 0.0999959012977383 no 409 0.0707305874043167 366 4446530 SGTC_520 3584-0023 682 µM 1.46962937913372 0.10011000206891 no 410 0.0708310794240454 434 1340790 SGTC_106 0092-0003 11.579 µM 1.46824837289908 0.100322593674304 no 411 0.0710183844637186 341 1072148 SGTC_858 0438-0351 2.77 µM 1.46555174894434 0.100738660454087 no 412 0.0713852222693601 460 2799119 SGTC_825 1988-2224 89.6 µM 1.46289870743414 0.101149229525864 no 413 0.0717475488796362 475 1180859 SGTC_2717 st081029 62.2815 µM 1.46180482557698 0.101318866818759 no 414 0.0718973506912535 391 5292846 SGTC_3142 9086498 49.47 µM 1.46013324831373 0.101578492331928 no 415 0.0721267282247827 421 25236367 SGTC_2793 7325131 81.82 µM 1.45925601967129 0.10171493513448 no 416 0.0722473277031441 393 4176441 SGTC_934 2950-0684 338 µM 1.45815054725546 0.10188706858569 no 417 0.0723995256473057 469 1121253 SGTC_177 1327-0068 8.361 µM 1.4568930192356 0.102083136317621 no 418 0.0725729566515938 466 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_770 0389-1121 67.2 µM 1.45679683986022 0.102098143437274 no 419 0.0725862342440196 510 6753108 SGTC_2711 st079103 59.1 µM 1.45433594599191 0.102482669255322 no 420 0.0729265945945952 399 54693780 SGTC_2035 5154463 94.595 µM 1.45303394539651 0.102686538160384 no 421 0.0731071646579017 477 2769623 SGTC_892 0929-0076 29 µM 1.45170114269709 0.102895535238334 no 422 0.0732923607283657 507 5751038 SGTC_2740 felodipine 17.08 µM 1.4508253677205 0.103033033853003 no 423 0.0734142469702396 354 3333 L-type calcium channel blocker SGTC_1883 5-benzylidenerhodanine 20 µM 1.44937316084702 0.103261327607566 no 424 0.0736166998740347 517 1273210 SGTC_2420 aureobasidin a 50 nM 1.44753063074065 0.103551510337872 no 425 0.0738741819574688 503 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3144 9087057 49.47 µM 1.44422229641257 0.104074029090431 no 426 0.0743382275038642 441 17249618 SGTC_1759 st043059 70 µM 1.44343479496664 0.104198688364662 no 427 0.074449014152453 488 669426 SGTC_16 erodoxin 22.806 µM 1.43812868566271 0.105041452986678 no 428 0.0751987724253889 532 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2856 9022925 19.48 µM 1.4355761481217 0.105448623272208 no 429 0.0755614929304941 481 4944862 SGTC_1988 st071872 53.4 µM 1.43287903360388 0.105880094977243 no 430 0.0759462049985855 408 16414116 SGTC_2390 9097792 176.6 µM 1.43148254435132 0.106103999487816 no 431 0.0761459831155317 429 4497149 SGTC_1781 st038725 66.3 µM 1.43084045689311 0.106207062568966 no 432 0.076237972610603 567 4270275 YIL048W NEO1 SGTC_384 k007-0144 5.16 µM 1.42862255962278 0.106563619114531 no 433 0.0765563732424583 525 6824886 SGTC_2939 9044578 71.43 µM 1.42603471448305 0.106980741069737 no 434 0.0769291609292109 449 2653634 SGTC_1336 1486-0901 104 µM 1.42101127124702 0.107793804539834 no 435 0.0776567413751726 460 5006114 SGTC_1762 st045503 25.4615 µM 1.41984316166348 0.107983503721121 no 436 0.0778266731048977 479 4645554 SGTC_1349 flufenamic acid 69 µM 1.41558886876484 0.108676426114737 no 437 0.0784479561233525 441 3371 A non-steroidal anti-inflammatory. SGTC_358 0075-0058 9.45 µM 1.4139320527414 0.10894714511953 no 438 0.078690926853021 584 1069125 SGTC_630 4356-0227 183 µM 1.41374059972813 0.108978459213055 no 439 0.0787190399993157 450 779312 SGTC_2462 5162487 171.77 µM 1.41150023538398 0.109345374549017 no 440 0.079048583128501 465 2259986 SGTC_44 0929-0055 61.211 µM 1.40877987154572 0.109792093638063 no 441 0.0794501343902453 435 1379590 SGTC_8 0354-0001 70 µM 1.40845495963187 0.109845535842244 no 442 0.0794981974585106 590 4993152 SGTC_1854 st056233 32.9 µM 1.40818561173893 0.109889852909652 no 443 0.0795380578159691 457 5393174 SGTC_2376 9072922 81.32 µM 1.4060603150534 0.110239988020956 no 444 0.0798531076477701 516 17087968 SGTC_2241 6772625 37.8075 µM 1.40506354170293 0.110404478251465 no 445 0.0800011921027144 462 2285411 SGTC_1822 st052468 42 µM 1.40450552962797 0.110496639708509 no 446 0.0800841831124475 442 2873678 SGTC_2976 9009005 19.48 µM 1.40314781734189 0.110721110229672 no 447 0.0802863823016123 468 2993148 SGTC_107 0358-0022 2.6945 µM 1.39639539533694 0.111842342057178 no 448 0.0812977304796475 335 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2032 5185112 25.99 µM 1.39116836012866 0.11271584412163 no 449 0.0820871896314896 439 5718189 SGTC_2502 avocadyne acetate 18.59 µM 1.38974740098378 0.112954143846869 no 450 0.0823027977218606 548 3952079 SGTC_1518 st038567 90.8 µM 1.38854901913932 0.113155395939482 no 451 0.082484964496288 423 77966 SGTC_3053 9095903 49.47 µM 1.38848497018408 0.113166159296852 no 452 0.0824947091564697 455 17174018 SGTC_3185 9108267 49.47 µM 1.38500578239862 0.113751930999148 no 453 0.0830253496278642 501 4910486 SGTC_816 0325-0417 81.3 µM 1.38411564836871 0.113902144542432 no 454 0.083161523066395 458 68101 SGTC_643 k048-0106 28.4 µM 1.37638337760634 0.115212943936822 no 455 0.0843514857420153 500 6763920 SGTC_967 1306-0166 352 µM 1.37392457517001 0.115632006589156 no 456 0.0847325496725611 506 4437607 SGTC_2855 9016525 58.44 µM 1.37077122213147 0.116171027264514 no 457 0.085223142287053 490 43811474 SGTC_1005 4092-0690 4.4 µM 1.37063369292409 0.116194576433474 no 458 0.0852445871508326 482 1529343 SGTC_478 N-arachidonylglycine 10 µM 1.37002683634496 0.116298529128765 no 459 0.0853392622904134 351 5283389 SGTC_1776 st049249 45.9 µM 1.36658171183965 0.116889919201784 no 460 0.085878226371394 526 1822314 SGTC_1361 1608-0041 5.61 µM 1.36535018320033 0.117101839690704 no 461 0.0860715066796384 514 X1361 SGTC_163 TUB2.036 7.546 µM 1.36509515204946 0.117145759254357 no 462 0.0861115727840763 679 15992207 YJR013W GPI14 SGTC_2765 myclobutanil 7.74 µM 1.36297685878131 0.117511006985237 no 463 0.0864449019529629 521 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_91 0417-1751 58.384 µM 1.36144572849744 0.117775514384643 no 464 0.0866864366740532 616 6795624 SGTC_279 1273-0055 2.93 µM 1.36060326081758 0.11792123279312 no 465 0.0868195502813463 548 2847562 SGTC_615 k087-0205 167 µM 1.35850199262924 0.118285236790468 no 466 0.0871522253657385 492 9642773 SGTC_3096 9117468 49.47 µM 1.35392186240458 0.119081406770548 no 467 0.0878806538951176 385 41316311 SGTC_1497 4476-2978 41.3 µM 1.35170262433328 0.119468537563012 no 468 0.0882352326074951 559 1528379 SGTC_1417 3966-0327 90.4 µM 1.34715779345922 0.120264121175779 no 469 0.0889647090125927 555 651118 SGTC_1342 1486-1464 234 µM 1.34694886254503 0.120300784563364 no 470 0.0889983514664564 539 3253938 SGTC_328 k915-0120 63.5 µM 1.3456866999491 0.120522437469534 no 471 0.0892017887180508 492 6624543 SGTC_311 1315-0136 58 µM 1.34323863714724 0.12095317005437 no 472 0.0895973572425198 522 6759207 SGTC_2093 5331342 194.4 µM 1.3430018302248 0.120994893223655 no 473 0.0896356906058978 521 33839 SGTC_599 1935-0052 86.5 µM 1.34172872538571 0.121219375973333 no 474 0.0898419847846969 537 9557311 SGTC_3165 9101544 49.47 µM 1.3416417213532 0.121234727818807 no 475 0.089856095808417 528 5002184 SGTC_19 0279-0214 38.434 µM 1.33780001930068 0.121913959010164 no 476 0.0904808178020623 626 3566274 YBR002C RER2 SGTC_935 2996-0153 430 µM 1.33610637843429 0.122214250176001 no 477 0.0907572527385935 507 23738523 SGTC_2747 doxorubicin 7.63 µM 1.32953037410958 0.123385130180437 no 478 0.0918365258494938 337 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_979 1426-2828 121 µM 1.32881905641354 0.123512252149943 no 479 0.0919538367794693 562 747872 SGTC_913 3487-1245 167 µM 1.32686245984999 0.123862395183515 no 480 0.0922770922188694 538 4016153 SGTC_237 nikkomycin 200 µM 1.32641542222682 0.123942492280647 no 481 0.0923510665970485 549 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1605 st000082 49.1 µM 1.3232534205522 0.124510072824264 no 482 0.092875558089147 506 1114022 SGTC_2470 5664817 21.68 µM 1.32001738905248 0.125092820684314 no 483 0.093414606149807 498 2859561 SGTC_72 0744-0168 198.391 µM 1.31911997658312 0.125254764475203 no 484 0.0935645028401497 518 677577 SGTC_1364 1653-0028 37.6 µM 1.31734968720714 0.12557465350643 no 485 0.0938607186655756 546 5718652 SGTC_3261 9137475 49.47 µM 1.31528524897947 0.125948414353257 no 486 0.0942070268836364 319 17027690 SGTC_3283 9109332 35.8195 µM 1.31417628228843 0.126149509681924 no 487 0.0943934440445202 442 17027281 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.31383496611539 0.126211447531716 no 488 0.094450873958755 564 165521 SGTC_2380 9035439 200 µM 1.31323853372809 0.126319731600587 no 489 0.0945512916065774 592 6462575 SGTC_2553 4-methylesculetin 85.09 µM 1.31114144856785 0.126700977549597 no 490 0.0949049897875044 533 5319502 SGTC_2438 5259590 200 µM 1.3098197500987 0.126941670969546 no 491 0.0951284100819215 554 1201127 SGTC_2213 7173844 200 µM 1.30922099613997 0.12705081424442 no 492 0.0952297510176967 558 892728 SGTC_1664 st014217 9.02 µM 1.30916727089284 0.127060610689953 no 493 0.0952388480648278 561 3982782 SGTC_1319 1306-0155 43.7 µM 1.30821822913164 0.1272337488778 no 494 0.0953996504097839 600 3122360 SGTC_2986 9022445 71.43 µM 1.30433484769002 0.127943922134836 no 495 0.0960597193417161 532 6459286 SGTC_1168 k815-0004 80.5 µM 1.3023617362756 0.128305808054059 no 496 0.096396378213914 548 642433 SGTC_719 2810-4230 27.3 µM 1.30211636206522 0.128350861472365 no 497 0.0964383053238337 488 721079 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.30145342948145 0.128472638144875 no 498 0.0965516476669083 586 5379071 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.30134475823717 0.128492608038015 no 499 0.0965702366460058 566 3256 An antibiotic and ribosome inhibitor. SGTC_2277 7947813 106.88 µM 1.29949865065292 0.128832185899377 no 500 0.0968864281177282 529 1246798 SGTC_184 1494-0393 24.714 µM 1.29936337044438 0.128857094152492 no 501 0.0969096280471811 563 3090647 SGTC_1315 1237-0019 3.69 µM 1.29277864898591 0.130073535518109 no 502 0.0980438134638635 563 825140 SGTC_2977 9011197 71.43 µM 1.28072340014176 0.132321128455646 no 503 0.100145418785638 480 2704722 SGTC_592 k241-0073 46.5 µM 1.27617644839562 0.133175778783082 no 504 0.10094657604006 599 4230158 SGTC_2679 rapamycin 1 nM 1.27408573226398 0.133570024390125 no 505 0.101316517162718 664 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2219 9098279 200 µM 1.27166975615735 0.134026602843689 no 506 0.10174524032924 536 902349 SGTC_2661 dactinomycin 12.96 µM 1.27024469480948 0.134296417482726 no 507 0.101998740761265 597 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1229 0139-0193 12.2 µM 1.26903109977164 0.134526487966774 no 508 0.102214986112514 611 3090752 SGTC_731 3966-0296 387 µM 1.26802588777928 0.134717258440195 no 509 0.102394352928193 563 660956 SGTC_3260 9137109 49.47 µM 1.26745887750284 0.134824948260026 no 510 0.102495629339901 456 17478346 SGTC_2923 7992654 58.14 µM 1.26101319336177 0.136053301528828 no 511 0.103652046889714 559 2985126 SGTC_110 0850-0284 111.64 µM 1.2599672115654 0.136253354314835 no 512 0.103840595331555 443 3906265 SGTC_831 k061-1017 217 µM 1.25821491541725 0.136588946504179 no 513 0.104157021101565 749 1240153 SGTC_2255 7941087 197.44 µM 1.25755805668844 0.136714890784519 no 514 0.104275815142132 656 935561 SGTC_1394 3474-0001 65.7 µM 1.25647059037602 0.136923573057283 no 515 0.10447270112145 517 5017666 YIL048W NEO1 SGTC_2506 ethyl hematommate 54.16 µM 1.25637035382915 0.136942819170813 no 516 0.104490862515354 488 3940691 An allergen. SGTC_2576 guaiol 23.12 µM 1.25564885459945 0.137081406582487 no 517 0.104621655097627 624 227829 SGTC_2205 7238770 200 µM 1.25356859931288 0.137481523621149 no 518 0.104999425247109 539 279867 SGTC_801 0866-0028 10.1 µM 1.25289372349525 0.137611500596503 no 519 0.105122193199265 617 6849771 SGTC_2782 7736369 71.43 µM 1.2473732715384 0.138677854954178 no 520 0.106130331167826 616 2950836 YOL077C BRX1 SGTC_2233 sulbentine 40.3845 µM 1.24636186271031 0.138873831525432 no 521 0.106315787906964 646 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2978 9011784 42.97 µM 1.23630796824983 0.140832188279809 no 522 0.108172055175956 696 2994934 SGTC_3031 9088762 49.47 µM 1.23596872539228 0.140898593164749 no 523 0.108235094499062 607 205253 SGTC_2151 5563267 85.4165 µM 1.23544388436444 0.141001369694087 no 524 0.108332674430278 612 5310824 SGTC_3340 9146634 11.102 µM 1.23388973623291 0.141306007531383 no 525 0.108621997312061 594 4907387 SGTC_2178 5812956 200 µM 1.2314138916635 0.14179223347545 no 526 0.109084051978269 564 5403383 SGTC_1357 1503-1303 39.5 µM 1.23065911448998 0.141940687687172 no 527 0.109225192868692 648 292895 SGTC_2140 5586273 200 µM 1.22899822655298 0.142267731783113 no 528 0.109536235470602 555 854421 SGTC_3176 9106582 49.47 µM 1.22832108362668 0.142401213644627 no 529 0.109663229690178 419 17018027 SGTC_870 0573-2213 57.6 µM 1.22802874963892 0.142458866182859 no 530 0.109718087886 576 3916321 SGTC_2155 5570423 76 µM 1.22018561849069 0.144011541216838 no 531 0.111197258716452 588 797402 SGTC_2200 6600604 21.907 µM 1.21839820253327 0.144366980080059 no 532 0.111536343917626 642 2904777 SGTC_144 4161-2749 112.381 µM 1.21826443242614 0.144393604863821 no 533 0.111561750761352 528 797501 YMR168C CEP3 SGTC_1834 st055981 52.8 µM 1.21710171027117 0.144625165350001 no 534 0.111782760039479 626 471719 YDL150W RPC53 SGTC_323 4013-0906 34.3 µM 1.21610261405623 0.144824338834714 no 535 0.111972917441625 587 2910086 SGTC_3060 1327-0027 12.5 µM 1.21141144126178 0.145762010208005 no 536 0.112868878304839 572 16000455 YPR107C YTH1 SGTC_367 0335-0881 7.1 µM 1.21096398129731 0.145851661188735 no 537 0.11295460469404 640 23828853 SGTC_3078 9116413 49.47 µM 1.20938484068407 0.146168346513111 no 538 0.113257514934323 555 17177322 SGTC_763 3453-1109 128 µM 1.20905343072375 0.146234866994093 no 539 0.113321159387126 639 1560353 SGTC_718 1130-0073 349 µM 1.20864959979741 0.146315951260285 no 540 0.113398746145116 639 6740020 SGTC_867 0518-0118 155 µM 1.20769903485119 0.146506932116762 no 541 0.113581524708071 616 6848158 SGTC_1732 st034308 51.822 µM 1.2030636215583 0.147440643634668 no 542 0.114475850778746 592 830119 SGTC_688 0527-0193 473 µM 1.19896442163039 0.148269660714466 no 543 0.11527089006543 581 4007154 SGTC_474 dl-dihydrosphingosine 5 µM 1.19838106453921 0.148387891096488 no 544 0.115384350343832 626 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3008 9078912 71.4286 µM 1.19418102258364 0.149240984657335 no 545 0.116203582420578 601 16648731 SGTC_63 0099-0242 26.702 µM 1.19218533233374 0.149647485779133 no 546 0.116594291698627 688 3898502 YLR359W ADE13 SGTC_1429 4049-0205 9.46 µM 1.19203223418408 0.149678700744778 no 547 0.116624303149614 669 22774478 SGTC_1643 st009866 20.2 µM 1.19126259856951 0.149835686470904 no 548 0.116775255898973 609 3156273 YOR207C RET1 SGTC_2038 4100038 30.985 µM 1.19034835351053 0.150022311436926 no 549 0.1169547516063 643 3596803 SGTC_2232 chlorophetanol 41.5365 µM 1.18998307414115 0.150096919276554 no 550 0.117026522334832 761 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_504 lovastatin 124 µM 1.18801539736557 0.150499240155029 no 551 0.117413671774033 551 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_344 k064-0035 6.43 µM 1.18734462021617 0.15063655458483 no 552 0.11754585731348 610 5088750 SGTC_1371 2421-0008 32.7 µM 1.18350192050775 0.151424799271485 no 553 0.118305142919237 627 2827552 SGTC_739 1486-1183 203 µM 1.18184068697905 0.151766412149699 no 554 0.118634460145991 661 4346692 SGTC_1935 st074532 41.6 µM 1.17995139860223 0.152155543732967 no 555 0.119009772757913 729 2829742 SGTC_1459 k035-0031 35.7 µM 1.17796482054476 0.152565427766288 no 556 0.119405315672028 554 3877128 YMR208W ERG12 SGTC_1735 st034310 56.75 µM 1.1773622651474 0.152689895684945 no 557 0.119525472209249 635 871153 SGTC_1449 4112-4002 201 µM 1.17707595511523 0.152749061422269 no 558 0.119582595635735 606 2059539 SGTC_2335 9018011 154.17 µM 1.17381918849034 0.153423139757634 no 559 0.120233728222489 675 6458208 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.17216035502511 0.153767237709163 no 560 0.120566340975728 625 140250 A respiratory chain inhibitor. SGTC_86 0417-1630 471.922 µM 1.17143841121822 0.153917152603685 no 561 0.120711300111992 760 3634867 SGTC_2616 abietic acid 100 µM 1.1713710951743 0.153931136012613 no 562 0.120724822754742 690 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1719 st032227 49.2 µM 1.17113473571577 0.153980241084005 no 563 0.120772311775734 624 3125804 SGTC_204 PMA1.184 62.41 µM 1.17081196048772 0.154047316281718 no 564 0.120837184571871 693 2252213 YGL008C PMA1 SGTC_748 act1.228 77.9 µM 1.17014315492852 0.154186360784047 no 565 0.120971682122923 677 4421505 YNR035C ARC35 SGTC_1007 4101-0031 70 µM 1.16923765829637 0.154374745533276 no 566 0.121153946310327 662 1146276 SGTC_1614 st002383 48.6 µM 1.16860913247806 0.154505597115117 no 567 0.121280573547122 658 1947235 SGTC_1402 3909-7673 35.9 µM 1.16307153032477 0.155661627552404 no 568 0.122400240938606 637 5328014 SGTC_610 4215-0184 155 µM 1.16156911315278 0.155976253625815 no 569 0.122705267168553 689 5605015 SGTC_1327 1436-0082 2.18 µM 1.16125644139084 0.156041783893801 no 570 0.122768813902636 638 15992205 SGTC_459 nigericin 15.3 µM 1.1599195238665 0.156322181913352 no 571 0.123040786454249 678 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2402 5553605 200 µM 1.15808923788812 0.156706594291194 no 572 0.123413810708836 673 6758546 SGTC_207 4185-0010 4.486 µM 1.15702423903732 0.156930560601824 no 573 0.123631228689836 745 3761753 SGTC_2316 5844804 197.44 µM 1.15538643626731 0.15727539673633 no 574 0.123966106915803 791 776813 SGTC_2828 7998861 71.43 µM 1.15534706395671 0.157283692625788 no 575 0.123974165098794 566 2988188 SGTC_2555 cholic acid 100 µM 1.15261694673975 0.157859639879739 no 576 0.124533822134201 650 6708657 Influences liver metabolism. SGTC_1171 0368-0077 21.4 µM 1.15111465372629 0.158177154566511 no 577 0.124842535115507 629 3239779 SGTC_637 1181-0519 7.26 µM 1.14983604236419 0.15844772332733 no 578 0.125105703644147 759 6252091 YGR060W ERG25 SGTC_1443 4112-3303 14 µM 1.14900795816591 0.158623117277236 no 579 0.125276349577816 677 704433 SGTC_3237 9133362 49.47 µM 1.14592545438062 0.159277131429112 no 580 0.125912998992213 658 43845137 SGTC_3155 9099265 49.47 µM 1.1449171257059 0.159491451065613 no 581 0.126121744527539 623 25236499 SGTC_2860 9025725 38.96 µM 1.14405709519654 0.159674399121942 no 582 0.126299979717126 626 40546248 SGTC_1661 st013063 9.66 µM 1.14095364959708 0.16033571398229 no 583 0.126944605897371 726 721395 SGTC_1663 st014140 55.4 µM 1.13928630786718 0.160691746808886 no 584 0.127291878676201 768 4207120 SGTC_1232 0279-0259 161 µM 1.13862223696786 0.16083369165333 no 585 0.127430374749666 674 1560000 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.13843440039926 0.160873856479708 no 586 0.127469568228229 680 97141 SGTC_1617 st002906 78 µM 1.13782634663989 0.161003920653525 no 587 0.127596500594538 689 5150859 SGTC_673 1082-0474 110 µM 1.13311670221247 0.162013648706474 no 588 0.128582624127579 771 3098046 SGTC_449 xestospongin c 11.1929 µM 1.13267425603824 0.162108718805777 no 589 0.128675536257102 707 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_791 1348-1292 225 µM 1.12641020221028 0.163458597228069 no 590 0.129995965207199 771 5437054 SGTC_853 0419-0306 21 µM 1.12583015896862 0.163583962473074 no 591 0.130118707968679 636 762713 SGTC_2372 9071633 200 µM 1.12523787656941 0.163712037382356 no 592 0.130244123390913 751 21321366 SGTC_582 0987-0078 156 µM 1.12300633214975 0.164195170130033 no 593 0.13071740257632 809 1625765 SGTC_668 1682-0499 62.6 µM 1.12274183031858 0.164252496410275 no 594 0.130773578403378 729 682214 SGTC_1275 0867-0008 21.1 µM 1.12250945658975 0.164302870178299 no 595 0.130822944519253 691 3422836 SGTC_2705 st078069 42.8 µM 1.12230413861494 0.164347387158805 no 596 0.130866573552622 631 1530061 SGTC_1676 st018489 23.4 µM 1.11357742674766 0.166246738302127 no 597 0.13273025744084 690 3696235 SGTC_2129 girgensonine 121.053 µM 1.11331417410194 0.166304254135043 no 598 0.132786760506348 746 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_550 4123-0385 25.7 µM 1.11306985218902 0.166357645449278 no 599 0.13283921520474 678 5731123 SGTC_1413 3910-0535 34.4 µM 1.11137054178647 0.166729299462886 no 600 0.133204443423186 728 2876951 SGTC_1039 k821-0043 94 µM 1.11074799742244 0.166865589333592 no 601 0.133338417994229 711 15992768 SGTC_1991 st073000 8.92 µM 1.10754263886923 0.16756845630365 no 602 0.1340296939721 753 4301969 YIL048W NEO1 SGTC_1685 st024049 53.0905 µM 1.10725146943466 0.167632397921185 no 603 0.13409261011011 674 1941139 SGTC_2556 citropten 84.59 µM 1.10567836956097 0.167978126788836 no 604 0.134432877780733 741 2775 A potential DNA crosslinker. SGTC_2256 7954252 200 µM 1.10553628615868 0.1680093758264 no 605 0.134463640142142 588 2972920 SGTC_1527 coumarin 137 µM 1.10490155434683 0.168149020916558 no 606 0.134601124425236 639 323 A hepatotoxic, DNA x-linker. SGTC_2164 5685496 200 µM 1.10424139879653 0.168294338596452 no 607 0.134744217871453 736 759046 SGTC_2062 5245942 200 µM 1.10408811488164 0.168328091988752 no 608 0.134777458185458 727 1376160 SGTC_1573 oleylamine 1.06 µM 1.09834602516203 0.169595646331289 no 609 0.136026710779912 699 5356789 An amine of the fatty acid oleic acid. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.0977706461547 0.169722996722518 no 610 0.136152326120149 662 364106 SGTC_2695 st077686 51.995 µM 1.09672757593145 0.169954018967516 no 611 0.136380249028628 670 2876092 SGTC_195 4234-0266 16.654 µM 1.08873145429302 0.171731714856594 no 612 0.138136163374609 767 2303354 SGTC_35 0133-0054 64.071 µM 1.08603927131 0.172332903369873 no 613 0.138730809047023 658 99677 SGTC_2539 epi(13)torulosol 80 µM 1.0846993481156 0.172632620005624 no 614 0.139027418347022 677 6708597 SGTC_829 1635-0120 117 µM 1.08201794766197 0.17323339820452 no 615 0.139622276532372 752 285054 SGTC_79 0052-0007 94.094 µM 1.07827976432851 0.174073171680089 no 616 0.140454462405438 739 2801472 SGTC_1684 st024538 14.6195 µM 1.07807539268753 0.174119157741272 no 617 0.140500056040629 722 6732859 SGTC_810 3825-7150 143 µM 1.07588648201364 0.174612172972396 no 618 0.140989014149503 784 22330411 YGL099W LSG1 SGTC_839 0122-0028 230 µM 1.07584880581556 0.174620666653504 no 619 0.140997440337018 768 759448 SGTC_2946 9065502 71.43 µM 1.07412784460251 0.175008917931603 no 620 0.141382693157304 556 16489101 SGTC_2587 piperic acid 92.2 µM 1.06967740753142 0.17601548000776 no 621 0.142382269526494 659 5370536 SGTC_2161 5662504 8.5105 µM 1.06733712259662 0.176546253364277 no 622 0.142909815270103 699 2859334 SGTC_1264 0783-0040 158 µM 1.06418682285589 0.177262333574804 no 623 0.143622037593616 698 2855798 SGTC_1952 st077036 64.1 µM 1.06279235267165 0.177579889028104 no 624 0.143938064150757 734 2937007 SGTC_2926 9010726 65.15 µM 1.05969522025863 0.178286466159686 no 625 0.144641638998591 722 2994293 SGTC_357 1325-0123 420 µM 1.05786370525026 0.17870513887689 no 626 0.145058792092083 728 1098503 SGTC_476 mead acid 10 µM 1.05647958467925 0.179021950391456 no 627 0.145374581570141 679 5312531 An omega 9 fatty acid. SGTC_264 promethazine 12.5 mM 1.05643732263307 0.179031629312598 no 628 0.145384230998385 874 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1186 1319-0216 26 µM 1.05569168851015 0.179202449773829 no 629 0.145554547823134 793 4565136 SGTC_166 k072-0058 166.424 µM 1.05043118627188 0.180410511545919 no 630 0.146759956790897 765 5846229 SGTC_1352 1496-0991 99 µM 1.04586667615669 0.181462870232644 no 631 0.147811295860957 753 3000039 SGTC_1292 0kpi-0043 232 µM 1.04110964173032 0.182563696129125 no 632 0.148912332611118 720 3333905 SGTC_2362 9071156 126 µM 1.04040076309499 0.182728094149836 no 633 0.149076873665123 763 653133 SGTC_99 0109-0120 622.8 µM 1.03859174781006 0.183148046642476 no 634 0.149497322661801 724 759414 SGTC_308 4092-1169 104 µM 1.03677160159893 0.183571190186552 no 635 0.149921156700741 802 2268590 YDL196W YDL196W SGTC_1959 st077091 55.8 µM 1.03562625754278 0.183837769284054 no 636 0.15018826861272 783 821356 YKL052C ASK1 SGTC_2469 5655019 90.81 µM 1.03514484926991 0.183949889108538 no 637 0.150300635079605 818 2788239 SGTC_886 0866-0150 153 µM 1.0320767271098 0.184665453795329 no 638 0.151018087650434 820 271463 SGTC_7 0192-1582 4.227 µM 1.03128553029197 0.184850261488883 no 639 0.151203470890665 869 252616 SGTC_3331 9141060 1.957 µM 1.03045080765531 0.18504536050096 no 640 0.151399216592209 731 4906567 YPR165W RHO1 SGTC_2819 7996655 46.38 µM 1.02939910143869 0.185291356955224 no 641 0.151646085598273 675 6456960 SGTC_1424 4048-1941 275 µM 1.02922965812607 0.185331009112563 no 642 0.151685884362119 855 X1424 SGTC_3108 9121785 49.47 µM 1.02759191494219 0.185714535933962 no 643 0.15207091448252 759 17140271 SGTC_1487 3970-0795 2.82 µM 1.02716997109066 0.185813426488309 no 644 0.152170217694632 805 3765103 SGTC_3052 9092717 49.47 µM 1.02607471476718 0.186070272988926 no 645 0.152428183864613 740 25237534 SGTC_580 1123-0028 41 µM 1.02553156581823 0.186197727421166 no 646 0.152556219549841 859 1677248 YPR107C YTH1 SGTC_820 1582-0060 59.9 µM 1.02476194507049 0.186378417971917 no 647 0.152737763248932 783 3848840 SGTC_1900 st060200 72.8 µM 1.02247402156254 0.186916214799284 no 648 0.153278301016258 785 688945 SGTC_1418 3966-3099 2.4 µM 1.02061155846238 0.187354711589073 no 649 0.153719255551412 804 740335 SGTC_2915 7971052 15.16 µM 1.01989466143992 0.187523666601058 no 650 0.153889210853058 615 5741558 SGTC_659 k018-0002 107 µM 1.01879335892027 0.187783399895148 no 651 0.154150539612731 805 6797879 YHR007C ERG11 SGTC_2413 inermin 26.06 µM 1.01754402538548 0.188078313956005 no 652 0.154447349921067 806 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_873 0591-4978 488 µM 1.01716897210629 0.188166903710909 no 653 0.154536526856784 855 3305145 SGTC_2507 purpurin 79.67 µM 1.01657620377592 0.188306971522273 no 654 0.154677539589041 783 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_744 1594-0068 283 µM 1.01509690416927 0.188656802133962 no 655 0.155029818609552 830 668392 SGTC_1926 methyl fluorone black 53.6 µM 1.01248883616722 0.189274543408333 no 656 0.155652190917795 706 72721 Reacts with homocysteine. SGTC_945 3381-0768 11.3 µM 1.01145075444895 0.189520767244391 no 657 0.155900369809054 835 1126236 YIL048W NEO1 SGTC_165 k038-0023 64.381 µM 1.00958401415448 0.189964037188496 no 658 0.156347315820978 796 46368543 SGTC_2883 9059145 45.46 µM 1.0067864004389 0.190629541348383 no 659 0.157018715666465 747 16476510 SGTC_790 1575-0012 79.1 µM 1.00559580450733 0.190913197225969 no 660 0.157305021458848 826 378741 YLR208W SEC13 SGTC_1880 MG-132 525 µM 1.00197270154001 0.191777982171817 no 661 0.158178388731006 750 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1629 st005085 44.9 µM 1.00050580845852 0.192128790467999 no 662 0.15853289404544 779 24207091 SGTC_3327 9140648 26.9345 µM 0.998031873179304 0.192721322206339 no 663 0.159131951643509 789 8029710 SGTC_1669 st015249 58.4 µM 0.995705388812012 0.193279555553079 no 664 0.159696655521219 842 722793 SGTC_3178 9107506 49.47 µM 0.995513926375555 0.193325540329474 no 665 0.159743187221498 797 8897194 SGTC_145 3737-0113 38.366 µM 0.994487585282086 0.193572157130911 no 666 0.159992773243807 918 6849351 SGTC_3276 9139060 49.47 µM 0.988531456227365 0.195007123885532 no 667 0.161446218329458 758 4870619 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.987659882827218 0.195217646814367 no 668 0.161659624024176 891 688801 SGTC_838 0109-0203 71.4 µM 0.987127032972782 0.195346421259323 no 669 0.161790183415822 823 759422 SGTC_1850 st056238 17 µM 0.985904569408136 0.195642050396149 no 670 0.162089972198533 858 5393177 SGTC_2433 5607874 27.82 µM 0.984833293334255 0.195901340945214 no 671 0.162352982002585 799 2252428 SGTC_2018 5133068 143 µM 0.984727656458163 0.195926920474519 no 672 0.162378932030638 774 785362 SGTC_1916 st067606 49.2 µM 0.984658775411118 0.19594360082445 no 673 0.16239585432868 852 19590279 SGTC_2154 5570129 200 µM 0.984185397783222 0.196058258050305 no 674 0.162512182060499 855 673366 SGTC_492 tmb-8 126 µM 0.983794719215394 0.19615291530683 no 675 0.162608228170985 663 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2189 6047310 154.431 µM 0.982231695278152 0.19653189652064 no 676 0.162992858091198 782 711535 SGTC_1482 3346-2049 8.48 µM 0.981389519481665 0.19673627988467 no 677 0.163200346236761 805 3826804 SGTC_1666 st014829 29 µM 0.980524613493327 0.19694631345556 no 678 0.163413613022996 851 3858230 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.980303159655686 0.197000113073737 no 679 0.163468247762334 824 6312947 SGTC_1561 5-methoxyflavone 52.9 µM 0.980161923705432 0.19703442934027 no 680 0.163503098191324 787 94525 SGTC_656 4090-1979 187 µM 0.979652513097583 0.197158231495141 no 681 0.163628836995743 881 22330961 SGTC_74 000s-0487 160.283 µM 0.979090225490731 0.197294938993021 no 682 0.16376770040763 884 677548 SGTC_2145 5634607 200 µM 0.977071844705068 0.197786134697471 no 683 0.164266792724067 771 308662 SGTC_2575 plumbagin 510 nM 0.969856105394941 0.19954819994043 no 684 0.166059111080951 806 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1774 st048371 48.465 µM 0.968237925322326 0.199944648513709 no 685 0.166462779092247 842 4242727 SGTC_1161 k007-0610 110 µM 0.966210372532438 0.200442059942778 no 686 0.166969461808357 922 5843850 SGTC_738 1315-0003 72.4 µM 0.964805164413563 0.200787229694789 no 687 0.167321204364647 845 6251474 SGTC_686 1319-0111 510 µM 0.964288512484936 0.200914227666809 no 688 0.16745064929725 879 4562600 SGTC_2040 5100729 123 µM 0.963923648348433 0.201003943781427 no 689 0.16754210331016 848 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_937 3122-0005 46.7 µM 0.963340320676422 0.201147427612635 no 690 0.167688382526802 885 759535 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.961440361658488 0.201615195058467 no 691 0.168165399210566 859 23665772 A membrane-active detergent. SGTC_2989 9073649 71.4286 µM 0.961156714195539 0.201685084557609 no 692 0.168236688504894 914 21367202 SGTC_280 3448-3607 3.04 µM 0.959900765750252 0.201994719116892 no 693 0.168552580393692 871 626179 SGTC_290 2043-6722 48.1 µM 0.958914320689892 0.202238111182989 no 694 0.168800954891513 840 773758 YLR208W SEC13 SGTC_2759 disulfiram 3.38 µM 0.95658681647054 0.202813086463298 no 695 0.169387922827199 794 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_765 1319-0117 244 µM 0.95587385250204 0.20298940880876 no 696 0.169567985346991 795 3487746 YGL099W LSG1 SGTC_2723 salbutamol 83.58 µM 0.955624045991092 0.203051209836018 no 697 0.169631104237669 784 9884233 β2-adrenoceptor agonist SGTC_560 2332-1943 155 µM 0.953856873060124 0.203488721375525 no 698 0.170078048152817 845 21177716 SGTC_203 k066-0004 30.888 µM 0.952469689023269 0.203832549997437 no 699 0.170429415566212 1004 6795412 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.952153059688841 0.203911078527069 no 700 0.17050968145931 869 229346 A bile salt which induces apoptosis. SGTC_953 1188-0045 9.7 µM 0.951869750345425 0.203981358511011 no 701 0.170581521213027 866 6144426 SGTC_2756 carbadox 75.1 µM 0.95146809895698 0.204081020101394 no 702 0.170683402584794 826 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1075 aripiprazole 15.2 µM 0.949383107650981 0.204598834042844 no 703 0.171212899320421 901 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1213 1315-0166 115 µM 0.947582312167279 0.205046695624401 no 704 0.171671067128129 743 768401 SGTC_322 k048-0136 19.3 µM 0.947166282555219 0.205150245854503 no 705 0.171777026832773 806 6823282 SGTC_1690 st023502 41.2 µM 0.943875674922438 0.205970376089075 no 706 0.172616591896008 837 24207482 SGTC_3312 9133330 71.43 µM 0.943308945886649 0.206111820093253 no 707 0.172761450705396 925 17617324 SGTC_1214 0358-0031 63.7 µM 0.939743944828935 0.207002891412389 no 708 0.173674459042922 832 4301366 SGTC_1493 4348-0038 111 µM 0.938988453556313 0.207192018607337 no 709 0.173868336300467 925 800424 SGTC_1032 k061-1018 98.7 µM 0.931911548902768 0.208968584485831 no 710 0.175691119329474 951 4005393 SGTC_2647 atorvastatin 60.16 µM 0.929457551807691 0.209586717872806 no 711 0.176326006950583 862 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_342 k048-0088 23.3 µM 0.927560067773066 0.210065408501545 no 712 0.176817909800029 856 6820570 SGTC_507 nimesulide 162 µM 0.925637048170794 0.2105511958998 no 713 0.177317316573171 897 4495 A COX2 inhibitor. SGTC_2026 5148700 152 µM 0.925253349324638 0.210648203577743 no 714 0.177417069365442 884 79838 SGTC_1145 3546-0597 10.2 µM 0.923827585326108 0.211008898390139 no 715 0.177788045229849 898 875334 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.923028623506986 0.211211180765532 no 716 0.177996144429968 918 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2699 st077704 54.6 µM 0.917259532290746 0.212675176902954 no 717 0.179503328806212 870 645852 SGTC_2053 5265679 138 µM 0.915830275991066 0.213038786525316 no 718 0.179877960611227 885 764595 SGTC_3355 9151058 44.0485 µM 0.914482441430282 0.213382014120578 no 719 0.180231699991686 892 17015728 SGTC_511 blebbistatin 171 µM 0.912705873600743 0.213834911236329 no 720 0.180698626977905 894 3476986 A myosin inhibitor. SGTC_1398 3558-0053 112 µM 0.910278630212785 0.214454587798218 no 721 0.18133779275115 834 4532369 SGTC_897 1000-0139 31.4 µM 0.909653647626372 0.214614315074875 no 722 0.181502598263331 904 6151020 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.908582152306427 0.214888318789364 no 723 0.181785365543453 887 2724278 An inhibitor of dopamine biosynthesis. SGTC_677 0929-0063 136 µM 0.908012435246021 0.215034090037153 no 724 0.181935825853655 837 1539583 SGTC_325 2810-4341 181 µM 0.906890464828323 0.215321331985426 no 725 0.182232361996853 911 774970 SGTC_2366 9070441 60.58 µM 0.905905223635533 0.215573752615703 no 726 0.182493009624773 930 6837235 SGTC_3254 9136651 49.47 µM 0.903955401567461 0.216073806194362 no 727 0.183009525179129 958 16454030 SGTC_1797 st048695 56.8 µM 0.90331797092743 0.21623742798758 no 728 0.18317858071989 905 592262 YIL048W NEO1 SGTC_1142 3253-1408 9.78 µM 0.901117385633203 0.216802846292841 no 729 0.183762955022447 898 256655 SGTC_1407 3909-7909 12.3 µM 0.897494940804815 0.217735456502157 no 730 0.184727435912132 955 4411780 SGTC_1648 st011736 69.8 µM 0.895176654707498 0.218333519372477 no 731 0.185346331099183 898 2855514 SGTC_1256 0570-0116 285 µM 0.893120974639979 0.218864626825476 no 732 0.185896195874746 859 410638 SGTC_2669 eugenol 100 µM 0.890091557714299 0.219648663075623 no 733 0.186708362861446 881 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2945 9067681 61.76 µM 0.889605564414645 0.219774591807282 no 734 0.186838858665188 914 16456930 SGTC_1259 0671-0132 43 µM 0.889373217354699 0.219834811332833 no 735 0.186901266946505 876 X1259 SGTC_845 0330-0138 4.51 µM 0.888322786451074 0.220107179344438 no 736 0.187183573010377 950 9039800 SGTC_502 l-744,832 89.3 µM 0.888134632575815 0.220155986514665 no 737 0.18723416769176 944 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2746 daunorubicin 9.88 µM 0.884335436954511 0.221142826134947 no 738 0.188257582037523 807 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_849 0386-0493 241 µM 0.884204748518263 0.221176817373256 no 739 0.188292847737142 913 726119 SGTC_1242 0402-0103 60.1 µM 0.883871922250044 0.22126339688516 no 740 0.188382677846565 876 432868 SGTC_3212 9128307 49.47 µM 0.883852030653408 0.22126857198458 no 741 0.188388047443424 799 27243542 SGTC_3270 9137563 49.47 µM 0.883847485118894 0.221269754583783 no 742 0.188389274491805 886 17015724 SGTC_125 0133-0007 11.75 µM 0.882181566371063 0.22170341547052 no 743 0.188839314355897 1043 26541 SGTC_700 3453-2283 142 µM 0.881826191748584 0.221795987033032 no 744 0.188935402751174 984 565664 SGTC_962 1254-0300 21.5 µM 0.880828988042398 0.222055866576225 no 745 0.189205193691887 922 7340576 SGTC_1734 st037168 69.4 µM 0.880400639710455 0.222167551047787 no 746 0.189321155043998 896 708907 SGTC_3271 9137798 49.47 µM 0.880023445856287 0.222265924406327 no 747 0.189423304204471 854 6498326 SGTC_1054 3429-0080 167 µM 0.8799169886345 0.222293693285284 no 748 0.189452140386127 963 1162877 SGTC_54 0159-0055 9 µM 0.876988188407124 0.223058433327502 no 749 0.190246526831205 935 3319099 SGTC_3187 9109394 49.47 µM 0.876625076422095 0.223153349898543 no 750 0.190345157062062 931 17098090 SGTC_3335 9143315 29.6265 µM 0.875076570557937 0.223558383513477 no 751 0.190766122147344 914 4899691 SGTC_996 3970-0799 1.8 µM 0.874691693338887 0.223659118433187 no 752 0.190870840533982 1110 6615648 YGL040C HEM2 SGTC_489 paxilline 115 µM 0.874316138388381 0.223757438286218 no 753 0.190973056482338 901 105008 A toxic potassium channel blocker. SGTC_1253 0550-0034 176 µM 0.873198754886401 0.224050113256992 no 754 0.19127737669829 881 5969915 SGTC_2196 6573537 42.6665 µM 0.872535819532747 0.224223857882624 no 755 0.19145806804187 964 2903087 SGTC_2031 5180455 200 µM 0.869946140371379 0.224903303548683 no 756 0.192164919292064 930 29949 SGTC_1714 st033236 13.627 µM 0.869747173267258 0.224955554133005 no 757 0.192219293197992 963 2916566 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.868920299704288 0.225172772402084 no 758 0.192445362745463 913 2346 DNA damaging agent; causes G2/M arrest. SGTC_2522 biochanin a 4.94 µM 0.867654258472258 0.22550558938902 no 759 0.192791816803695 942 5280373 A possible chelator. SGTC_377 3970-0964 33.1 µM 0.865633619581493 0.226037351428771 no 760 0.193345556430674 1029 16481235 SGTC_2916 7875993 68.79 µM 0.865607827387422 0.226044143617585 no 761 0.19335263083849 942 1299250 SGTC_3259 9138485 49.47 µM 0.863338179647113 0.226642290601406 no 762 0.193975779145602 1017 17646153 SGTC_2830 7992007 71.43 µM 0.863181723259161 0.226683556282106 no 763 0.194018780426112 909 1952075 SGTC_2784 7567673 72.73 µM 0.862530957131671 0.226855242620838 no 764 0.194197702658746 986 3471247 SGTC_2804 7954240 19.48 µM 0.858983632631338 0.227792393038414 no 765 0.195174773059021 972 828705 SGTC_2378 9074213 121.43 µM 0.857364866196182 0.228220769984543 no 766 0.195621634957635 1004 657714 SGTC_3216 9129716 49.47 µM 0.856252959609873 0.228515277918863 no 767 0.19592893732186 899 8056934 SGTC_1471 k673-0312 37 µM 0.854846569135671 0.22888809067562 no 768 0.196318046706593 981 24099884 SGTC_2881 9058953 51.95 µM 0.854182220025043 0.229064318175237 no 769 0.196502016543972 1010 17122249 SGTC_1478 0453-0656 35.7 µM 0.854018021992651 0.229107885630456 no 770 0.196547501933817 983 5258496 SGTC_3069 9117009 49.47 µM 0.85392633062972 0.229132216563952 no 771 0.196572904632463 844 41904981 SGTC_1249 0481-0015 10.2 µM 0.853001099552801 0.229377814070587 no 772 0.196829347222699 944 4227577 SGTC_3351 9150312 21.596 µM 0.852095548112132 0.229618330541633 no 773 0.197080531343712 950 4904905 SGTC_1615 st002656 86.5 µM 0.85080148193313 0.229962282457735 no 774 0.197439819157663 958 1584458 SGTC_525 k781-2675 26.7 µM 0.850427090744834 0.230061846245313 no 775 0.19754383990178 1005 3651118 YDL195W SEC31 SGTC_2684 capsaicin 100 µM 0.850070864741473 0.230156601660591 no 776 0.197642844388903 958 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1820 st053765 18.6 µM 0.849951063347639 0.230188473500567 no 777 0.197676147055355 961 3690829 SGTC_694 1315-0438 43.2 µM 0.849521899878541 0.230302667970666 no 778 0.197795474734336 912 6793154 SGTC_1990 st072050 59.8 µM 0.848840066215418 0.230484159619262 no 779 0.197985146119462 989 17233948 SGTC_62 0180-0423 3.232 µM 0.847909557420398 0.230731972986056 no 780 0.198244170728813 952 30102 YGL099W LSG1 SGTC_3097 9117246 49.47 µM 0.847057230146764 0.230959095572007 no 781 0.198481611446827 1005 16423892 SGTC_963 1269-2853 151 µM 0.84666866404243 0.231062679527355 no 782 0.198589914825134 949 3668223 SGTC_1882 5615643 20 µM 0.844524536283273 0.231634727174482 no 783 0.199188179177259 949 2253075 SGTC_2722 naftopidil 47.16 µM 0.844508806122684 0.231638926854402 no 784 0.199192572286312 987 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1051 3253-3903 78 µM 0.840046942329487 0.232831878766976 no 785 0.200441033528373 1027 5509239 SGTC_405 ebelactone b 50 µM 0.839378229250876 0.233010963762871 no 786 0.200628548358269 963 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_430 0958-0115 16.4 µM 0.838585810225781 0.233223276879164 no 787 0.200850888052889 919 6833180 SGTC_2251 lansoprazole 556 µM 0.838072005471014 0.233360998135468 no 788 0.200995132170209 819 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3291 9121177 71.43 µM 0.836435708763492 0.233799894916912 no 789 0.201454915467249 892 17015612 SGTC_1841 st054148 70 µM 0.835731544807062 0.233988910471598 no 790 0.201652972447193 911 675442 SGTC_294 k038-0071 157 µM 0.834764170832768 0.234248716270533 no 791 0.201925251404831 1000 24152826 SGTC_2343 7990716 14.84 µM 0.83465566128325 0.234277868432508 no 792 0.201955806435063 997 6456862 SGTC_2457 5731572 11.68 µM 0.834050960437081 0.234440364059483 no 793 0.202126133858538 1031 2865357 SGTC_3203 9113543 49.47 µM 0.832247304903339 0.234925413817701 no 794 0.202634683799648 968 17018012 SGTC_1151 3909-8316 15.3 µM 0.832059662163677 0.234975907646289 no 795 0.202687634515442 985 800431 SGTC_363 0455-0021 3.06 µM 0.83157130877191 0.235107349484353 no 796 0.202825481225355 993 4597466 SGTC_2497 7-hydroxyflavone 100 µM 0.830795433600264 0.235316262196541 no 797 0.203044601374747 933 5281894 SGTC_2328 6201408 200 µM 0.829345599831259 0.235706920012694 no 798 0.203454437381016 933 2890418 SGTC_1158 4092-0494 91.8 µM 0.829101362282593 0.235772765020748 no 799 0.203523526481785 1036 1148199 SGTC_66 0109-0187 42.4 µM 0.828093379991066 0.236044618396196 no 800 0.203808809157219 909 759417 SGTC_2612 dictamnine 15.46 µM 0.827965094735468 0.236079229384751 no 801 0.20384513398983 944 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2036 5160441 105 µM 0.827294294326351 0.236260254909646 no 802 0.20403513846874 1046 134534 YIL048W NEO1 SGTC_3316 9136639 10.545 µM 0.824919446251286 0.236901757129679 no 803 0.204708662622084 996 4903665 SGTC_2524 avocatin b 10.57 µM 0.824086836230728 0.237126891150498 no 804 0.204945109629461 971 6710748 SGTC_1824 st053723 68.6 µM 0.823411110335915 0.237309690786199 no 805 0.205137123533822 1036 675225 SGTC_1805 st050013 60.3 µM 0.821056118595914 0.237947375478471 no 806 0.205807151754944 976 4037144 SGTC_2956 9076196 2.52 µM 0.820708283750486 0.238041641764314 no 807 0.205906225597457 1018 16423868 SGTC_2138 5575593 77.673 µM 0.820313418913507 0.238148678392383 no 808 0.20601872928031 1040 762213 SGTC_2319 6033012 152.6 µM 0.81919294009793 0.238452551882509 no 809 0.206338171112644 936 847246 SGTC_1581 himbacine 57.9 µM 0.817015929484594 0.239043562909475 no 810 0.206959662407889 989 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1087 pterostilbene 9.05 µM 0.816350568376761 0.23922435361815 no 811 0.207149829973675 1029 5281727 Similar to reservatol, lowers cholesterol. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.815025144524618 0.239584717917252 no 812 0.207528958655902 1040 4213774 SGTC_1653 st012112 65 µM 0.814748479870085 0.239659976552141 no 813 0.207608148443552 1003 720429 SGTC_2566 crystal violet carbinol 226 nM 0.814563300379157 0.239710356495602 no 814 0.207661162385396 929 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_543 3844-1095 191 µM 0.813005892067118 0.240134293701937 no 815 0.208107340007417 1028 4230703 SGTC_2742 clothiapine 36.27 µM 0.811422006896854 0.240565856908524 no 816 0.208561682706726 980 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_819 1013-0258 27.7 µM 0.811337079826153 0.240589009017661 no 817 0.208586060826062 1021 5753198 SGTC_1623 st003709 20.3 µM 0.810829387492048 0.240727437161851 no 818 0.208731827771141 1020 16192618 SGTC_557 1315-0110 16.2 µM 0.807544657165674 0.241624103170925 no 819 0.209676378436638 1078 6833801 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.807387748958952 0.241666981320411 no 820 0.209721561467625 1021 688667 SGTC_1363 1636-0063 10.4 µM 0.807079317053123 0.241751278238971 no 821 0.209810393700711 1070 6072185 SGTC_443 clozapine 122 µM 0.805025427672146 0.242313029465866 no 822 0.210402503284411 948 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3127 9126946 49.47 µM 0.803707140619123 0.24267396137295 no 823 0.210783064622206 907 27243249 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.802639556971773 0.242966466719227 no 824 0.211091548886853 1055 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2327 6189656 200 µM 0.802003741128215 0.243140763351221 no 825 0.211275397086242 1036 5349088 SGTC_540 1187-0821 17.3 µM 0.801340535847531 0.243322640283175 no 826 0.211467264948493 996 847520 SGTC_1613 st002381 52.1 µM 0.799438125440757 0.243844763635214 no 827 0.212018205476435 1081 551167 SGTC_657 3534-0529 86.7 µM 0.799160607313734 0.243920979983029 no 828 0.212098645188126 1062 1049549 SGTC_3064 1327-0027 10 µM 0.798784363216432 0.244024330516318 no 829 0.212207729498865 912 16000455 YPR107C YTH1 SGTC_199 4063-0024 41.6 µM 0.797083371984455 0.24449187064152 no 830 0.212701306378999 1069 306215 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.796519325561106 0.244647012801765 no 831 0.212865123686177 1055 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2677 mitomycin C 100 µM 0.796462835109388 0.244662553539906 no 832 0.212881534394594 1045 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_441 propafenone 146 µM 0.795022398701167 0.245059002608951 no 833 0.213300236493878 1055 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3073 9114972 49.47 µM 0.794786571828781 0.245123941773665 no 834 0.213368831712973 968 41905075 SGTC_2112 5488546 200 µM 0.794676677789427 0.245154206232 no 835 0.213400801103911 1045 600757 SGTC_1838 st055369 84.5 µM 0.794483513326871 0.245207407961879 no 836 0.213457001548389 1060 676036 SGTC_2186 6124449 200 µM 0.794193712655211 0.245287237065183 no 837 0.213541334097169 1033 3834182 YLR033W RSC58 SGTC_912 3474-0017 2.18 µM 0.79282479894285 0.245664509707084 no 838 0.213939952972999 1069 3360550 SGTC_954 1189-0853 2.85 µM 0.792249536606992 0.245823144958386 no 839 0.214107594855688 1090 2828194 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.791787306331365 0.245950650140958 no 840 0.214242352518156 1080 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3278 9139605 49.47 µM 0.789276537366561 0.246643859604342 no 841 0.214975198349544 1036 7958859 SGTC_691 1548-0686 185 µM 0.789043433624496 0.246708271305245 no 842 0.215043310684307 1056 46495133 SGTC_390 dec-rvkr-cmk 16.7 µM 0.788755643741221 0.246787806415633 no 843 0.215127419456341 1089 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1367 1812-0510 76.9 µM 0.785558567328691 0.247672289654208 no 844 0.216063072942177 1042 1142582 YDR527W RBA50 SGTC_300 r073-0011 5.04 µM 0.784554915147568 0.247950302565385 no 845 0.216357286300964 1099 2735780 SGTC_2878 9043973 25.97 µM 0.784513704318114 0.24796172157519 no 846 0.216369371911074 1055 6465167 SGTC_87 0100-0052 35.5 µM 0.783890259930154 0.248134504514736 no 847 0.216552252725614 1184 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1395 3486-0190 4.35 µM 0.782333388788477 0.248566259949727 no 848 0.217009334709572 1102 6748079 SGTC_679 0422-0091 41.4 µM 0.782306320075314 0.248573770251804 no 849 0.217017286744444 1122 627384 YHR062C RPP1 SGTC_2127 5253358 187.912 µM 0.777938362877022 0.249787256152684 no 850 0.218302675442381 1011 20612 SGTC_219 mitoxanthrone 164.414 µM 0.777499661845327 0.249909307647502 no 851 0.218432016942268 1037 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3196 9111891 49.47 µM 0.777174903978776 0.249999679274407 no 852 0.218527793189978 1107 18891510 SGTC_2771 fluoxetine 41.05 µM 0.775994879288439 0.25032819523148 no 853 0.218876004684504 1047 3386 A selective serotonin reuptake inhibitor. SGTC_1724 st037281 8.293 µM 0.773372734037623 0.251059012506883 no 854 0.219650910824109 1081 574124 YDL195W SEC31 SGTC_750 4073-0104 132 µM 0.772627879296541 0.251266816413561 no 855 0.219871320051153 912 22330957 SGTC_1845 st056753 3.01 µM 0.771276018171527 0.251644198685443 no 856 0.220271672012501 1089 5375839 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.770711423532085 0.251801898135826 no 857 0.220438999655414 1028 689007 SGTC_1432 4049-0298 68.4 µM 0.770165883065618 0.251954325030599 no 858 0.220600749437697 1084 741646 SGTC_421 streptovitacin 30 mM 0.766759604545422 0.252907157424665 no 859 0.221612228954223 1084 91467 include heat shock SGTC_2523 spermine 47.74 µM 0.766513859782937 0.252975972454978 no 860 0.221685304148722 1067 1103 A DNA binding polyamine. SGTC_1755 st041960 45.185 µM 0.766007209549319 0.253117879006305 no 861 0.221836006204925 1083 2257073 SGTC_65 0798-0905 34.986 µM 0.763137981892202 0.253922303999507 no 862 0.222690555218908 1137 3602145 SGTC_3222 9128301 49.47 µM 0.761761356685989 0.254308734381317 no 863 0.223101223983878 1133 4911358 SGTC_1018 4259-0013 28.1 µM 0.76086205164968 0.254561343320781 no 864 0.223369733399368 1073 6801262 SGTC_1879 gemcitabine 100 µM 0.760725216798607 0.254599790859486 no 865 0.223410604888044 1100 60750 A nucleoside analog which inhibits DNA replication. SGTC_3149 9097855 49.47 µM 0.758485126789324 0.255229638367276 no 866 0.224080306793803 1076 25236625 YMR079W SEC14 SGTC_1034 k072-0165 12.7 µM 0.757885444995738 0.255398389406721 no 867 0.224259782196653 1112 5835461 SGTC_330 1488-0319 80.1 µM 0.757629571422499 0.255470410222173 no 868 0.224336385998882 1063 6846614 SGTC_1297 1068-0111 14.1 µM 0.754724548605048 0.256288831458623 no 869 0.225207136919906 1090 767057 SGTC_391 gliotoxin 8.33 µM 0.749599945047915 0.257735891871278 no 870 0.226747841969664 1124 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2331 7980721 200 µM 0.749427506764113 0.257784657800401 no 871 0.22679978852723 1105 2981221 SGTC_1082 camptothecin 424.86 nM 0.74769928912739 0.258273665964317 no 872 0.227320780023833 1106 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1947 st076332 61.6 µM 0.746779228957218 0.25853419774363 no 873 0.227598417790474 1112 24208416 SGTC_891 0929-0073 133 µM 0.745149899424286 0.258995905762622 no 874 0.228090553116668 1127 5603632 SGTC_3324 9138759 60.749 µM 0.743713566494206 0.259403277142301 no 875 0.22852489010089 1121 45595710 SGTC_2600 tangeritin 87.95 µM 0.741765649690199 0.259956271817743 no 876 0.229114668049678 1112 68077 A bioactive flavone. SGTC_549 1661-1316 519 µM 0.741169766902735 0.260125558520876 no 877 0.229295256061907 1157 2857282 SGTC_1104 tacrolimus 29.8 µM 0.740767674031543 0.260239822781771 no 878 0.229417159254475 1148 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1931 st074438 57.1 µM 0.740592262420016 0.260289678268523 no 879 0.229470350474019 1120 2787313 SGTC_319 1348-1596 45.5 µM 0.740123130836183 0.260423039019766 no 880 0.229612642290542 1146 5380505 SGTC_2229 7354935 190 µM 0.739238308811832 0.260674664474478 no 881 0.229881151225508 1098 318112 SGTC_2083 5306046 65.942 µM 0.738223404655028 0.260963436647568 no 882 0.230189351331927 1144 539837 SGTC_2382 9035899 200 µM 0.736710741757037 0.261394141945766 no 883 0.230649136551527 1172 6462679 SGTC_1091 telmisartan 47.6 µM 0.734785972051918 0.26194271505468 no 884 0.231234925857913 1205 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_841 0251-0215 91.2 µM 0.7335748268799 0.262288202409831 no 885 0.231603953895329 1163 3888614 SGTC_2299 7976368 114.88 µM 0.733368063073446 0.262347206500599 no 886 0.231666986264817 1119 2979718 SGTC_2787 5284540 71.43 µM 0.733093314672129 0.262425621839948 no 887 0.231750758666555 1127 736958 SGTC_1826 st055655 41.6 µM 0.732040352664063 0.262726256507185 no 888 0.232071969206006 1108 676168 SGTC_3305 9127027 53.8275 µM 0.731986355021175 0.262741678300661 no 889 0.232088448094674 1093 41905295 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.730650017274213 0.263123485489367 no 890 0.232496476345508 1194 688751 SGTC_2221 6807166 181.081 µM 0.730320853971194 0.263217574756959 no 891 0.23259704201765 1101 674925 SGTC_1907 st060210 83.7 µM 0.726383210346815 0.264344456439009 no 892 0.233801940482214 1178 688793 SGTC_2710 st078562 53.7235 µM 0.726328117250125 0.264360240481461 no 893 0.23381882318532 1140 17250908 SGTC_906 1165-0455 526 µM 0.726147970591009 0.264411855424112 no 894 0.233874031960425 1149 3252859 SGTC_1274 0865-0114 173 µM 0.726055016554574 0.264438490270768 no 895 0.233902522010788 1160 870624 SGTC_644 1498-1197 63.3 µM 0.723315539863461 0.265224066585475 no 896 0.234743023844541 1183 6741615 SGTC_622 1348-1566 26.3 µM 0.72310960134335 0.265283169666049 no 897 0.234806275476753 1184 7340407 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.723024583621155 0.265307571175827 no 898 0.234832390433031 1127 4620898 SGTC_2370 9071495 200 µM 0.722327908604302 0.2655075714832 no 899 0.235046449078327 1108 21791103 SGTC_1309 pyrazolanthrone 13.4 µM 0.720257858203849 0.266102289052181 no 900 0.235683123175543 1172 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2955 9076254 12.21 µM 0.719939175545535 0.266193905246412 no 901 0.235781223074235 1108 16459619 SGTC_2109 5483026 200 µM 0.719527227128508 0.266312357520704 no 902 0.235908066272328 1161 759335 SGTC_1255 0566-0045 221 µM 0.718102535104025 0.266722221182688 no 903 0.236347033586643 1152 2788469 SGTC_2518 prenyletin 46.28 µM 0.717396280053248 0.266925518869161 no 904 0.2365648071417 1087 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2920 7982904 15.77 µM 0.717187110880911 0.266985743878684 no 905 0.236629325585885 1119 6456808 SGTC_642 0335-0876 158 µM 0.711969900805375 0.268490125377642 no 906 0.238241707413811 1176 6812350 SGTC_111 0083-0039 52.457 µM 0.711714417627951 0.268563903207685 no 907 0.238320818925799 1095 759313 SGTC_2810 7959871 45.46 µM 0.709947236496283 0.269074504459399 no 908 0.238868428263412 1182 2974535 SGTC_2254 7938975 95.19 µM 0.708458247473613 0.269505103997187 no 909 0.239330365863231 1202 2969277 SGTC_3012 9080433 71.4286 µM 0.705570867958089 0.270341085935487 no 910 0.240227523090905 1198 17688859 SGTC_2333 9017922 200 µM 0.704873945331333 0.270543059715975 no 911 0.240444342877254 1187 3163164 SGTC_36 0335-0881 14.2 µM 0.703963083797695 0.270807148309366 no 912 0.240727881860128 1147 23828853 SGTC_639 0833-0042 114 µM 0.703322761370989 0.270992875748594 no 913 0.240927314516668 1182 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1465 k213-0056 144 µM 0.702836653933789 0.271133915087528 no 914 0.241078775883471 1111 24048857 YMR208W ERG12 SGTC_2496 diffractaic acid 79.83 µM 0.700754577313644 0.271738423183945 no 915 0.241728094727911 1226 94870 An apoptosis inducer which activates caspases. SGTC_2569 tetrandrine 100 µM 0.700620055068776 0.271777503300254 no 916 0.241770079613375 1135 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_635 k038-0028 24.7 µM 0.699326551815662 0.272153422188684 no 917 0.242173988625493 1211 4035102 SGTC_368 fentichlor 4.58 µM 0.69894465167363 0.272264459695012 no 918 0.242293310579418 1156 7329 A pesticide. SGTC_1126 isoteolin 1.0172 µM 0.698644967568782 0.272351608640697 no 919 0.242386967030163 1184 133323 SGTC_1294 1000-1494 117 µM 0.698278599730378 0.27245816821856 no 920 0.242501489939439 1178 712797 YDL207W GLE1 SGTC_2738 aclarubicin 5.55 µM 0.697629307139416 0.272647068460527 no 921 0.242704524262906 1101 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2545 solidagenone 89.61 µM 0.696908795360047 0.272856764729784 no 922 0.242929936559566 1026 6708572 An anti ulcer agent SGTC_936 3005-4620 401 µM 0.694598334482343 0.273529735585759 no 923 0.243653528154813 1208 777207 SGTC_1117 retinoic acid 1.10837 µM 0.694169409068653 0.273654759583355 no 924 0.243787987249638 1212 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1568 digitonin 820 nM 0.694020572425263 0.27369814937849 no 925 0.243834653764904 1209 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_155 k072-0202 43.6 µM 0.693051017236539 0.273980883476243 no 926 0.244138767845189 1149 5857737 SGTC_1817 st052116 64.4 µM 0.692686796381917 0.274087131998398 no 927 0.244253063462922 1207 4361398 SGTC_2741 miltefosine 3.04 µM 0.692587975482394 0.274115963003062 no 928 0.244284079280178 1111 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2294 7971431 200 µM 0.691034973089784 0.274569248250493 no 929 0.244771781600411 1131 5741572 SGTC_2982 9019404 25.97 µM 0.690221664762458 0.274806781464084 no 930 0.245027400586185 1093 22333232 SGTC_1463 k081-0032 34.1 µM 0.68992452604918 0.274893588464109 no 931 0.245120825691647 1061 977755 SGTC_2833 9001315 45.46 µM 0.689345602904486 0.275062755621155 no 932 0.24530290328424 1196 2989378 SGTC_1765 st044815 90.4 µM 0.688118306302696 0.27542155350451 no 933 0.2456891416574 1191 645695 SGTC_27 0485-0001 32.618 µM 0.686091433859214 0.276014609595662 no 934 0.246327726178344 1143 2054479 SGTC_2932 9016711 44.54 µM 0.6860192159133 0.27603575188919 no 935 0.246350495499936 1200 7117328 SGTC_1027 k015-0025 8.67 µM 0.685358484272317 0.276229222470564 no 936 0.246558867433615 1199 3598955 SGTC_727 3032-0951 202 µM 0.683385625449899 0.276807296157999 no 937 0.24718160038319 1188 3652836 SGTC_2409 alverine citrate 63.97 µM 0.682393815788463 0.277098133148424 no 938 0.247494982565358 1270 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_575 k072-0246 11.9 µM 0.681223925400064 0.277441382414143 no 939 0.247864905650688 1230 6796779 SGTC_893 0958-0369 48.9 µM 0.680078702008068 0.277777595504528 no 940 0.24822731462274 1226 6819948 SGTC_1209 2323-2347 50.3 µM 0.679802446998605 0.277858727840072 no 941 0.248314778533439 1201 5412760 SGTC_197 4544-0043 41.561 µM 0.678388000213891 0.27827431275795 no 942 0.248762857745437 1224 896523 SGTC_780 0109-0199 192 µM 0.677814321702803 0.278442954134193 no 943 0.248944714628573 1245 610414 SGTC_2429 5902844 64.44 µM 0.675322835461802 0.279175941001514 no 944 0.249735339414468 1244 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1948 st076329 66.6 µM 0.67463530628871 0.279378374772787 no 945 0.249953747954374 1141 24208413 SGTC_1047 2043-3044 82 µM 0.673694006992277 0.279655643354066 no 946 0.250252936393371 1226 669592 SGTC_2841 9004761 38.96 µM 0.671858168887893 0.280196790707244 no 947 0.250836996527268 1145 2991039 SGTC_6 0844-0013 19.835 µM 0.671297589258723 0.280362133008935 no 948 0.251015485056348 1330 1584900 SGTC_578 3460-0051 92 µM 0.670360395610095 0.280638662645147 no 949 0.251314037499922 1297 2876744 SGTC_336 4111-0029 111 µM 0.667630490283744 0.281444903379806 no 950 0.252184744958946 1187 3131175 SGTC_597 k018-0003 82.8 µM 0.663118347430565 0.282779949103971 no 951 0.253627380402255 1321 6786234 SGTC_84 0443-0269 128.823 µM 0.661391860548601 0.283291582851827 no 952 0.254180522211247 1208 6150058 SGTC_413 propylparaben 100 µM 0.661127259102488 0.283370035076351 no 953 0.254265352620599 1226 7175 A pharmaceutical preservative. SGTC_1874 staurosporine 7.6 µM 0.660354062183081 0.283599341487338 no 954 0.254513322207594 1268 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_244 nsc-207895 1.295 µM 0.658728058068604 0.284081854113481 no 955 0.255035206040135 1154 42640 SGTC_1080 nisoldipine 24.4 µM 0.657167427399098 0.284545336329222 no 956 0.255536633568406 1242 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2983 9022671 12.99 µM 0.652681493927426 0.285879593663086 no 957 0.256980817731559 1281 6405161 SGTC_710 3448-4187 58 µM 0.65217233504404 0.286031221261994 no 958 0.257145002287658 1284 3946412 SGTC_1972 st070201 17.4 µM 0.652139089925667 0.286041122992698 no 959 0.257155724482427 1252 2829099 SGTC_2549 cedrol 20.94 µM 0.65167339809414 0.286179841831447 no 960 0.25730594355249 1234 6708665 A sedative which affects the nervous system. SGTC_1773 st048542 73.5835 µM 0.648919084305534 0.28700094095253 no 961 0.258195339299081 1202 3237138 SGTC_2894 9048625 32.47 µM 0.648089128904871 0.287248580765845 no 962 0.258463652411168 1339 4092861 SGTC_2126 5251174 33.877 µM 0.647933644539962 0.287294985008214 no 963 0.258513934416534 1311 790722 SGTC_1318 1280-3875 124 µM 0.647060680295303 0.287555586658639 no 964 0.258796335900043 1264 373245 SGTC_3341 9147222 25.867 µM 0.64628965297301 0.28778585049203 no 965 0.259045893781283 1257 1939759 SGTC_1416 3966-0321 25.3 µM 0.645881557092588 0.28790776172877 no 966 0.259178032240469 1277 582530 YLR208W SEC13 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.644632588504592 0.288281019868214 no 967 0.259582655513413 1263 521171 SGTC_1473 k844-0725 134 µM 0.643710243232871 0.288556812027486 no 968 0.259881673185095 1324 54682906 SGTC_1682 st012968 530 nM 0.641753871391374 0.289142201492524 no 969 0.260516502431857 1237 24207270 SGTC_638 3970-0837 4.09 µM 0.640354330197455 0.289561317310357 no 970 0.260971133377756 1270 4118451 YLR208W SEC13 SGTC_3288 9119690 36.221 µM 0.638752046214719 0.29004149774995 no 971 0.261492124313006 1257 17595618 YKL019W RAM2 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.637975443857069 0.290274368034645 no 972 0.261744832590375 1268 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.637226856712136 0.290498920595672 no 973 0.261988543192059 1284 4330530 SGTC_1233 0325-0408 14.2 µM 0.636832241345648 0.290617325489636 no 974 0.262117061282303 1329 12874 SGTC_2766 oltipraz 83.91 µM 0.63656846821258 0.290696483575637 no 975 0.26220298476666 1311 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_921 1561-0023 372 µM 0.635939871555944 0.290885165520124 no 976 0.262407806821753 1278 24050882 SGTC_256 clotrimazole 625 nM 0.635159023585558 0.291119627477475 no 977 0.262662352517819 1288 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3083 9117465 49.47 µM 0.63478113881772 0.291233125039739 no 978 0.262785583101368 1266 16420915 SGTC_1441 4106-0040 13 µM 0.63367186256465 0.291566415049485 no 979 0.263147495744882 1275 2904180 SGTC_835 0312-0010 67.2 µM 0.633452938362181 0.29163221340512 no 980 0.26321895206606 1261 1626196 SGTC_1298 1079-1278 263 µM 0.632301873730054 0.291978283317532 no 981 0.263594819716654 1315 2840950 SGTC_1084 voriconazole 435 nM 0.629688877033378 0.292764594956823 no 982 0.264449080671658 1305 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1689 st020265 53.493 µM 0.629235758304677 0.2929010489254 no 983 0.264597360948062 1329 5758320 YPR016C TIF6 SGTC_2792 7535235 81.82 µM 0.628497022734241 0.293123577949661 no 984 0.264839198208064 1265 1281891 SGTC_519 k048-0011 62.8 µM 0.626218594850241 0.293810401217144 no 985 0.26558578612711 1315 6836379 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.62604213698296 0.293863624807849 no 986 0.26564365177941 1325 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1218 1348-1416 30.7 µM 0.625543368727488 0.294014088444033 no 987 0.265807246924086 1287 6787668 SGTC_1063 disulfiram 1.84 µM 0.624164539000539 0.294430225818621 no 988 0.26625976629963 1296 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2593 nobiletin 86.24 µM 0.62043901899811 0.295555963030139 no 989 0.267484395127496 1260 72344 An anti-infammatory. SGTC_175 3793-3120 23.7 µM 0.618081451200305 0.296269368150338 no 990 0.268260824340699 1307 5322297 SGTC_3188 9110789 49.47 µM 0.617466428257238 0.296455605226007 no 991 0.268463559138397 1346 849217 SGTC_1942 st076330 65.2 µM 0.615840646262747 0.296948171692636 no 992 0.268999849005874 1344 24208414 SGTC_2961 9083290 32.55 µM 0.614913252834838 0.297229313562609 no 993 0.269306005054522 1326 17741490 SGTC_386 1509-0011 3.07 µM 0.613835679472464 0.297556135604961 no 994 0.26966195864187 1335 3107280 SGTC_957 1187-1561 14.1 µM 0.613474025827629 0.297665859912391 no 995 0.269781476081124 1292 1538454 SGTC_3153 9100258 49.47 µM 0.613045912914591 0.297795771561962 no 996 0.269922990914813 1271 25236848 SGTC_2884 9058502 51.95 µM 0.609447732706287 0.298888666491349 no 997 0.271113853623393 1321 6471554 SGTC_2970 9090938 41.86 µM 0.608749336015333 0.299101005317731 no 998 0.271345299999084 1334 17217104 SGTC_2459 5811157 9.22 µM 0.607417257818605 0.299506196871572 no 999 0.271787019173357 1292 2870684 YBR192W RIM2 SGTC_236 1509-0011 5.31 µM 0.606510000981032 0.299782308621834 no 1000 0.272088071654072 1372 3107280 SGTC_2618 avocadyne 43.43 µM 0.605221798206273 0.300174554178516 no 1001 0.272515816989144 1300 3015189 SGTC_2859 9028643 45.46 µM 0.603536535537277 0.300688050800456 no 1002 0.273075908969172 1284 17151580 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.603442787888626 0.30071662718395 no 1003 0.273107082462601 1331 16486 A toxic proline analog. SGTC_1167 k781-0610 148 µM 0.601359341590693 0.301352024299599 no 1004 0.273800336498207 1368 4525169 SGTC_2423 st077119 87.2 µM 0.598053843056118 0.302361353865079 no 1005 0.274902003491689 1297 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2212 7123476 200 µM 0.59751354722424 0.302526476557898 no 1006 0.275082282484725 1318 1085715 SGTC_758 0868-0029 16 µM 0.596566789785583 0.302815917582838 no 1007 0.275398324727763 1345 762687 SGTC_1370 2001-0092 44.6 µM 0.59175061694025 0.30429022526549 no 1008 0.277008798100782 1491 790957 SGTC_296 1222-0039 74.9 µM 0.591464435951608 0.304377930385343 no 1009 0.277104638679238 1306 5984176 SGTC_1384 3089-0840 101 µM 0.591200489410426 0.304458831348454 no 1010 0.277193047434956 1372 1069836 SGTC_2701 st077767 14.721 µM 0.590884524636473 0.304555688748013 no 1011 0.277298897813528 1348 5721188 SGTC_3139 9095020 49.47 µM 0.589374649034068 0.305018722599463 no 1012 0.277804989314126 1184 25236292 SGTC_3068 9116768 49.47 µM 0.588468301815943 0.305296822356879 no 1013 0.278109002072213 1336 41904888 SGTC_1848 st056003 16.4 µM 0.586720567828471 0.305833407004418 no 1014 0.278695695924316 1392 146492 SGTC_885 0865-0106 16.8 µM 0.585754746004391 0.306130110066397 no 1015 0.279020169309926 1306 2793380 SGTC_201 4262-0159 12.803 µM 0.581697253383253 0.307377970848225 no 1016 0.280385310958406 1348 1341029 SGTC_690 glyoxal 20.3 µM 0.580453679430684 0.307760873319942 no 1017 0.280804357423115 1268 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2246 7293507 91.5585 µM 0.580034165157878 0.307890091077449 no 1018 0.280945789206689 1405 887656 SGTC_1970 st070122 35.8 µM 0.579217186059717 0.308141803346542 no 1019 0.281221317961769 1420 102928 SGTC_832 4083-0019 164 µM 0.578635179276941 0.308321175418755 no 1020 0.281417681120765 1479 1990758 SGTC_1655 st012546 55.1 µM 0.578566972351001 0.308342199507231 no 1021 0.281440697773301 1338 720985 YLR208W SEC13 SGTC_31 0508-1974 57.237 µM 0.57781082765369 0.308575315490724 no 1022 0.281695922134286 1343 6810525 SGTC_2111 5486399 200 µM 0.575968151348989 0.309143727314991 no 1023 0.28231835447829 1359 689674 SGTC_961 1252-1571 372 µM 0.575965799606532 0.30914445305125 no 1024 0.282319149289243 1451 6813498 SGTC_3093 9117344 49.47 µM 0.57584744533088 0.309180977565663 no 1025 0.282359150499496 1369 24824913 SGTC_2414 st077232 92.9 µM 0.575300073207373 0.30934992291067 no 1026 0.282544186009441 1330 729801 SGTC_2874 9043904 71.43 µM 0.573800753620245 0.309812891345134 no 1027 0.283051319361526 1350 4463428 SGTC_1286 0929-0070 131 µM 0.5729238752225 0.31008379877923 no 1028 0.283348119090809 1444 1420408 SGTC_2272 7805186 180 µM 0.572652551888677 0.310167643737447 no 1029 0.283439984955381 1357 2956062 YPR165W RHO1 SGTC_1981 st071826 47 µM 0.571471555108932 0.31053271300168 no 1030 0.283840018346191 1345 11838600 SGTC_95 0471-0001 561.058 µM 0.570747277140291 0.310756693905057 no 1031 0.284085483187101 1288 4015405 SGTC_2601 securinine 100 µM 0.570159719495351 0.310938445978936 no 1032 0.284284686747897 1343 442872 A GABA receptor antagonist. SGTC_359 0081-0058 15.9 µM 0.568742839946109 0.311376925927138 no 1033 0.284765335261627 1530 3494159 SGTC_1698 5-fluorocytosine 1.055 µM 0.568551663652564 0.31143610952845 no 1034 0.284830217740912 1411 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2692 st077426 47.7 µM 0.568313385978144 0.311509881411095 no 1035 0.284911095623153 1382 25238571 SGTC_606 k015-0008 38.6 µM 0.567482086042909 0.311767315002682 no 1036 0.285193347030908 1482 1970475 SGTC_1115 galangin 695.678 nM 0.566914362575666 0.311943178184842 no 1037 0.285386182819722 1420 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2703 st077852 53.4 µM 0.565702786597435 0.312318630335382 no 1038 0.285797920305939 1399 6281836 SGTC_164 4100-3994 89.624 µM 0.565221230103076 0.31246791279958 no 1039 0.285961649101448 1468 4615967 SGTC_55 0767-0285 6.563 µM 0.560888412995852 0.313812467660398 no 1040 0.287436804735921 1360 3116166 SGTC_451 chloral hydrate 100 µM 0.560361973723514 0.313976000760165 no 1041 0.287616281748822 1432 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2997 9067075 71.4286 µM 0.560000390938131 0.314088344009786 no 1042 0.287739585521238 1433 27209819 SGTC_1927 st060202 13.8 µM 0.559511889195999 0.314240148158097 no 1043 0.287906209729949 1375 688887 SGTC_3033 9090887 49.47 µM 0.558922695154735 0.314423284708912 no 1044 0.288107239908371 1357 19325384 SGTC_1922 5578187 25 µM 0.556916072300213 0.315047336815492 no 1045 0.288792386452199 1484 1350412 SGTC_1811 st050069 61.5 µM 0.555719953702623 0.315419576612833 no 1046 0.289201156861222 1402 3877702 SGTC_1631 benzylvanillin 81.9 µM 0.555649030583369 0.315441654232787 no 1047 0.289225403192107 1440 75506 SGTC_612 0302-0167 22.4 µM 0.555478619559715 0.315494704082872 no 1048 0.289283665140218 1480 235821 SGTC_2948 9070189 9.45 µM 0.552871567890221 0.31630676661129 no 1049 0.290175678836089 1398 6473636 YDL196W YDL196W SGTC_2604 4'-hydroxychalcone 11.32 µM 0.552374355399718 0.316461742601607 no 1050 0.290345948403493 1416 5282362 SGTC_2363 9053361 176 µM 0.552010769385462 0.316575089006855 no 1051 0.290470487419315 1513 6469797 YMR079W SEC14 SGTC_2081 5214970 32.255 µM 0.551447278730659 0.316750788876642 no 1052 0.290663549104219 1443 2063512 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.55008973377283 0.317174249519522 no 1053 0.29112891390179 1394 688669 SGTC_2436 5633522 8.09 µM 0.549766085315168 0.317275240950546 no 1054 0.291239911551848 1440 5724242 SGTC_1350 1495-0454 146 µM 0.548971719062845 0.317523173076836 no 1055 0.291512429092923 1465 1069057 SGTC_216 k038-0035 28.382 µM 0.548723223497852 0.3176007486196 no 1056 0.291597703100464 1376 4444231 YPR107C YTH1 SGTC_471 1-acyl-paf 4 µM 0.54859248156567 0.317641566955693 no 1057 0.291642573312413 1346 16759367 SGTC_1042 0350-0096 82 µM 0.547152149741036 0.318091392958805 no 1058 0.292137103486689 1386 3122515 SGTC_2397 5161689 200 µM 0.547027278789139 0.318130403712008 no 1059 0.29217999563164 1497 2259942 SGTC_2182 6325192 200 µM 0.546340979642622 0.318344845442744 no 1060 0.292415786035407 1367 736248 SGTC_2680 butyl paraben 22.24 µM 0.542884901064251 0.319425659384199 no 1061 0.293604526218663 1440 7184 An antifungal and steroid mimetic. SGTC_948 3448-0295 75.3 µM 0.542078003102374 0.319678220801564 no 1062 0.293882385722402 1433 678569 SGTC_2055 5235184 200 µM 0.540884851328712 0.320051834053009 no 1063 0.294293476471577 1438 2836034 SGTC_182 3448-4371 550.524 µM 0.54059723369291 0.320141923480383 no 1064 0.294392612503954 1495 3491403 SGTC_1943 st076331 65.2 µM 0.539065910493431 0.320621752713074 no 1065 0.294920688291983 1449 24208415 SGTC_49 0717-0965 32.132 µM 0.538189182056296 0.320896604396362 no 1066 0.295223223881513 1505 5889349 YGL099W LSG1 SGTC_2434 5670830 169.91 µM 0.536541755553609 0.321413333065408 no 1067 0.29579209290293 1430 1549830 SGTC_3304 9125678 46.087 µM 0.532754664379646 0.322602494844284 no 1068 0.297101710141157 1421 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1545 lovastatin 49.4 µM 0.532109455739088 0.322805274409325 no 1069 0.297325094359994 1475 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2935 9038016 29.96 µM 0.532036152188638 0.322828315969427 no 1070 0.297350478378345 1418 6463195 SGTC_1859 st055998 20 µM 0.531802929650161 0.322901629509318 no 1071 0.297431246743191 1562 676301 SGTC_1731 st035964 63 µM 0.531156564356268 0.323104850498252 no 1072 0.297655144814155 1457 6739575 SGTC_537 1334-0398 209 µM 0.530920137218062 0.323179197753419 no 1073 0.297737061333907 1512 5846986 SGTC_385 1494-0393 12.4 µM 0.530798700711844 0.323217387616895 no 1074 0.297779140264255 1456 3090647 SGTC_802 4112-3352 742 µM 0.529924131607087 0.323492480795322 no 1075 0.298082267046538 1539 704594 SGTC_3315 9136395 68.55 µM 0.529770025097367 0.323540964556231 no 1076 0.298135695128532 1481 16876844 SGTC_2134 5324836 1.464 µM 0.527990643256536 0.324100996298876 no 1077 0.298752915095202 1489 699272 SGTC_327 1273-0057 3.96 µM 0.527833935499421 0.32415033663918 no 1078 0.298807300641446 1403 3108138 SGTC_1995 st072814 61.1 µM 0.527423879577555 0.324279459722689 no 1079 0.298949632145856 1399 5769371 SGTC_2666 tannic acid 100 µM 0.526675242116348 0.324515253729933 no 1080 0.299209565603479 1470 16134267 A thiamine antagonist. SGTC_462 ag-879 158 µM 0.526507250683602 0.324568174688697 no 1081 0.299267907780398 1515 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1461 k072-0203 53.8 µM 0.525214039186872 0.324975682994412 no 1082 0.299717203209833 1376 5418714 SGTC_1626 st003712 1.76 µM 0.525173422568049 0.324988485231926 no 1083 0.299731319430707 1468 24207035 SGTC_1366 1683-0113 21.9 µM 0.524982476804116 0.325048673538288 no 1084 0.299797686266338 1436 708623 SGTC_3150 9097574 49.47 µM 0.524933823150644 0.325064010460813 no 1085 0.29981459783358 1516 17217476 SGTC_2472 5377652 49.4 µM 0.523585863589573 0.325489040871457 no 1086 0.300283307960937 1423 1610903 SGTC_729 4092-0585 94.1 µM 0.522248548866683 0.325910939190453 no 1087 0.300748643695372 1411 2169061 SGTC_2068 5226020 147 µM 0.522202868802219 0.325925354356478 no 1088 0.300764544402756 1417 1810509 SGTC_528 3492-0019 172 µM 0.52019325581675 0.326559781139701 no 1089 0.3014644427261 1475 2869262 SGTC_1980 st071811 45.7 µM 0.519894406749939 0.326654169511837 no 1090 0.301568587014234 1495 4974850 SGTC_234 nsc-17383 10.7 µM 0.519698105663279 0.326716175208891 no 1091 0.301637003719827 1514 408974 SGTC_576 1073-0113 22.7 µM 0.517709788272743 0.327344495280171 no 1092 0.302330383922499 1554 5439563 SGTC_465 cgp-37157 41 µM 0.517397139450676 0.327443338738736 no 1093 0.302439478070906 1442 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1421 4029-0249 71.4 µM 0.516787464025184 0.32763612150736 no 1094 0.302652265984193 1539 2894095 SGTC_415 dibenzyl ketone 100 µM 0.516048567752054 0.327869826229012 no 1095 0.302910244218063 1563 7593 SGTC_450 aminopyrene 156 nM 0.515631069510263 0.328001906125367 no 1096 0.303056053056093 1502 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2876 9059903 25.97 µM 0.514675041920903 0.328304436375202 no 1097 0.303390058360801 1444 6916095 SGTC_735 3076-0345 636 µM 0.512074739922731 0.329127858536109 no 1098 0.304299351238897 1554 2888990 SGTC_627 1391-0720 175 µM 0.509342883893035 0.329993832948218 no 1099 0.305255951891249 1446 997839 SGTC_2274 7947094 46.08 µM 0.507422233092382 0.330603208607056 no 1100 0.30592929451965 1441 2971028 SGTC_1489 4065-0444 182 µM 0.506566303780712 0.330874918939422 no 1101 0.30622957820417 1545 2877968 SGTC_1679 SEC14.276 6.7 µM 0.503619166216537 0.331811153474838 no 1102 0.307264510742058 1555 1005053 YMR079W SEC14 SGTC_834 0312-0008 75.7 µM 0.502838123527095 0.332059448376807 no 1103 0.307539043810505 1493 6385573 YIL048W NEO1 SGTC_2131 toluylene red 5.2905 µM 0.502115723239813 0.332289166414895 no 1104 0.307793060334768 1429 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3002 9075603 71.4286 µM 0.501370344643937 0.332526257451499 no 1105 0.308055253285294 1465 20105405 SGTC_3131 9127911 49.47 µM 0.501005772425902 0.332642245488445 no 1106 0.308183530208365 1517 45595681 SGTC_2365 9042475 200 µM 0.499879632965321 0.333000626004938 no 1107 0.308579917060506 1459 6464479 SGTC_383 2324-0395 7.37 µM 0.498633909977331 0.333397240311306 no 1108 0.309018655800193 1541 3146421 SGTC_1127 asiatic acid 681.4 nM 0.494105552787685 0.334840549392576 no 1109 0.310615818256846 1466 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_751 0833-0568 350 µM 0.494004095381983 0.334872914652504 no 1110 0.310651643596122 1511 6954252 SGTC_1379 2144-0755 36.5 µM 0.493766158585131 0.334948822116446 no 1111 0.310735667832424 1538 5392327 SGTC_1743 st037606 46.3785 µM 0.493305425193298 0.335095826129924 no 1112 0.310898397805648 1508 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_783 0848-0141 92.7 µM 0.489912279944619 0.336179237740845 no 1113 0.312097986525112 1468 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2662 daunorubicin 22.37 µM 0.489655877029117 0.336261161169624 no 1114 0.312188714644812 1447 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1680 diphenhydramine 100 µM 0.487564042328064 0.336929814567599 no 1115 0.312929335100793 1488 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_403 arphamenine a 50 µM 0.486035421876924 0.337418763194133 no 1116 0.313471025893041 1545 5487158 An arginine aminopeptidase inhibitor. SGTC_1436 4092-1007 8.32 µM 0.484411800185811 0.337938399972511 no 1117 0.314046822768211 1496 2881121 SGTC_2879 9041815 71.43 µM 0.484021414261405 0.338063388299074 no 1118 0.31418533579815 1472 4942971 SGTC_320 4092-0846 5.34 µM 0.483123632826893 0.338350895169426 no 1119 0.314503977377555 1560 1359356 SGTC_1957 st077035 62.4 µM 0.482309947775804 0.338611552332231 no 1120 0.314792890801418 1538 705593 SGTC_2063 5246145 200 µM 0.481379846905768 0.338909597033154 no 1121 0.315123278638823 1552 711240 SGTC_426 0988-0037 14.6 µM 0.479658330518427 0.339461511649294 no 1122 0.315735181090101 1517 5383008 SGTC_1303 1160-0052 261 µM 0.478814359968105 0.339732212797482 no 1123 0.316035349987521 1515 3562476 SGTC_2282 7944268 200 µM 0.478139896936749 0.339948604340919 no 1124 0.316275318600645 1581 2970414 SGTC_1662 st014054 52 µM 0.477476270142484 0.340161570717513 no 1125 0.316511507310828 1483 2838777 SGTC_1019 4262-0212 3.4 µM 0.477220823848978 0.340243560317743 no 1126 0.316602442116906 1532 4677213 SGTC_1467 k284-1082 293 µM 0.477190635638256 0.340253250209113 no 1127 0.316613189370983 1593 3334705 SGTC_569 4130-2812 160 µM 0.476038137857785 0.340623260817693 no 1128 0.317023603875748 1512 743552 SGTC_584 0986-0246 15.4 µM 0.475819055404528 0.340693614832137 no 1129 0.317101646536395 1581 53315 YDR232W HEM1 SGTC_671 0560-0003 407 µM 0.473919176845637 0.341303955610028 no 1130 0.317778771783104 1556 3238678 SGTC_2147 5545932 89.7195 µM 0.472995383536321 0.341600876723672 no 1131 0.318108236377788 1528 797404 SGTC_1806 st050005 60.3 µM 0.471934495268369 0.341941983171913 no 1132 0.318486772572761 1471 5194765 SGTC_2199 6590217 200 µM 0.471574173210192 0.342057866572903 no 1133 0.318615382451218 1552 703109 SGTC_1521 st012942 49.4 µM 0.466761365326959 0.343607139524802 no 1134 0.320335310038553 1709 24207259 SGTC_3138 9097216 49.47 µM 0.46514504693129 0.344128033944212 no 1135 0.320913794353599 1503 25237486 SGTC_3050 9093513 49.47 µM 0.464540181667562 0.344323041317507 no 1136 0.321130389051488 1502 25236664 SGTC_2440 5628896 157.78 µM 0.464301801794006 0.344399905895185 no 1137 0.321215766632148 1550 5522048 SGTC_1485 3909-9022 254 µM 0.46267892794025 0.344923365341126 no 1138 0.321797262323183 1532 714516 SGTC_283 0987-0079 11.7 µM 0.461906595340957 0.345172586279258 no 1139 0.322074152079094 1587 411556 SGTC_3183 9108214 49.47 µM 0.461838186349361 0.345194664144421 no 1140 0.322098682222048 1505 4974831 SGTC_2903 5923464 63.88 µM 0.461734894861003 0.345228000754048 no 1141 0.322135722023053 1548 2876576 SGTC_1792 st045773 43.6 µM 0.461249595384988 0.345384643858098 no 1142 0.32230977158364 1527 2919270 SGTC_1238 0333-0287 48.8 µM 0.459732139258262 0.34587461331125 no 1143 0.322854248791536 1518 7226 SGTC_859 0439-0102 54.6 µM 0.459383120958048 0.345987343934726 no 1144 0.322979533549739 1590 610143 SGTC_3180 9109287 49.47 µM 0.459364229722005 0.345993446069702 no 1145 0.322986315383238 1527 18891271 SGTC_1622 st003707 19.4 µM 0.459248219878256 0.346030919757969 no 1146 0.323027963469093 1570 10140899 SGTC_2179 6298986 200 µM 0.456867761570513 0.346800191727287 no 1147 0.323883048600776 1649 738374 SGTC_2121 5257820 149.641 µM 0.456651824730862 0.34687000546636 no 1148 0.323960661424432 1623 791256 SGTC_2730 imipramine 71.33 µM 0.456458170109847 0.346932619646114 no 1149 0.324030271999826 1569 3696 A tricyclic antidepressant. SGTC_1011 4112-3381 17.4 µM 0.456131528905117 0.347038241732648 no 1150 0.324147699521177 1578 2877139 SGTC_1633 st005664 67.9 µM 0.455933499378612 0.347102281975776 no 1151 0.324218899660974 1526 2063822 SGTC_904 1141-0088 396 µM 0.452869613955123 0.348093659180535 no 1152 0.325321316202109 1455 1378119 SGTC_2073 5212005 126 µM 0.451455698824934 0.348551508583585 no 1153 0.325830573655076 1520 691789 SGTC_1369 1866-0067 208 µM 0.448221270628409 0.349599699639902 no 1154 0.326996756564695 1664 3531355 SGTC_2004 4023728 41.89 µM 0.447771053396362 0.349745694092839 no 1155 0.327159218118795 1648 360084 YDR527W RBA50 SGTC_1372 2752-0194 270 µM 0.446723401968517 0.350085507850823 no 1156 0.327537391432125 1498 823334 SGTC_2933 9026794 32.47 µM 0.445790864348323 0.350388084589738 no 1157 0.327874160762842 1612 17586027 SGTC_88 0180-0332 8.668 µM 0.445789473377992 0.350388535983279 no 1158 0.327874663191619 1593 3101745 SGTC_1711 st032263 62.8 µM 0.445612001875234 0.350446130238807 no 1159 0.327938769767093 1596 3958979 SGTC_1856 st057054 55.7 µM 0.444935050539514 0.350665850639764 no 1160 0.328183345885453 1668 1266018 SGTC_2592 piperlongumine 83.33 µM 0.444779488936519 0.350716348861621 no 1161 0.328239559236099 1488 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2649 anisomycin 9.56 µM 0.444652150197069 0.350757687374508 no 1162 0.328285576938701 1545 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1178 0988-0033 191 µM 0.444629870263522 0.350764920385087 no 1163 0.328293628734001 1601 5392207 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.444617206909701 0.350769031470477 no 1164 0.328298205207475 1601 5357218 A potent inhibitor of glutathione S-transferases. SGTC_112 phenothiazine 287.218 µM 0.44199016640888 0.351622262308178 no 1165 0.329248160918136 1697 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1266 0828-0227 32.9 µM 0.441743762830949 0.351702329632846 no 1166 0.329337318823026 1612 3913820 SGTC_1620 st003704 16.5 µM 0.439914463055863 0.352296954821167 no 1167 0.329999530154679 1585 2834414 SGTC_1772 st048439 82.2 µM 0.438548579914399 0.352741179227219 no 1168 0.330494331187476 1556 2927068 YDL195W SEC31 SGTC_250 brefeldin a 552.239 µM 0.437949666607947 0.352936026408234 no 1169 0.330711385403308 1517 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1153 4055-0057 267 µM 0.437839814377974 0.352971769320102 no 1170 0.330751203506514 1534 882706 SGTC_400 oxethazaine 37.5 µM 0.437152679431101 0.353195373672059 no 1171 0.331000312535991 1549 4621 A local anesthetic. SGTC_1175 0741-0056 27.6 µM 0.436256242883809 0.353487164205178 no 1172 0.331325412773793 1677 765927 SGTC_3133 9127736 49.47 µM 0.435970016180136 0.35358034928458 no 1173 0.331429242083725 1682 27243420 SGTC_3347 9188721 44.724 µM 0.433515294366083 0.354379877903787 no 1174 0.332320228689714 1600 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1933 st074711 15.9 µM 0.432069573738259 0.354851064993586 no 1175 0.332845423851971 1534 17250958 SGTC_455 paf C-16 10 µM 0.428555996193725 0.355997129546438 no 1176 0.334123187325147 1577 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2384 9036245 200 µM 0.428139202344621 0.356133166667634 no 1177 0.334274888459038 1670 6462766 SGTC_862 0452-0056 10.2 µM 0.427917180292515 0.356205639803965 no 1178 0.33435570923895 1564 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2474 5321570 43.32 µM 0.427917005331348 0.356205696917388 no 1179 0.334355772931588 1668 2841384 SGTC_2852 9023854 51.95 µM 0.427889972096944 0.356214521546063 no 1180 0.334365614132838 1646 19798528 SGTC_3242 9133940 49.47 µM 0.426860271366865 0.356550710521212 no 1181 0.334740551941644 1615 17248444 SGTC_1401 3807-4679 7.6 µM 0.426117883883956 0.356793163223085 no 1182 0.335010974644894 1604 3291456 SGTC_1464 k208-0027 110 µM 0.426051280426033 0.356814917750984 no 1183 0.335035239861949 1671 X1464 SGTC_78 0336-0123 156.75 µM 0.423991112137971 0.357488055248913 no 1184 0.335786147579608 1538 6765896 SGTC_2750 bromebric acid 70.15 µM 0.423428051324964 0.357672106500979 no 1185 0.335991491080186 1638 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2148 5546263 113.568 µM 0.420728002986976 0.358555147658744 no 1186 0.336976855203731 1606 792097 SGTC_3297 9117502 71.43 µM 0.419939713580999 0.358813097826525 no 1187 0.337264747505547 1604 7453720 SGTC_2769 toremifene 3.73 µM 0.419206717553659 0.359053012258022 no 1188 0.337532531560038 1624 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2309 7664088 163.95 µM 0.418342835922631 0.359335837786025 no 1189 0.337848237446972 1727 704922 SGTC_3230 9131665 49.47 µM 0.417966169944382 0.359459178307472 no 1190 0.337985925916099 1598 15943720 SGTC_406 estrone 100 µM 0.416722108906446 0.359866654207109 no 1191 0.33844084050569 1709 5870 A steroid. SGTC_781 4335-2806 94.4 µM 0.416190322802333 0.360040882414797 no 1192 0.338635370218357 1730 845254 SGTC_1321 1326-2144 215 µM 0.416166960882372 0.36004853710931 no 1193 0.338643917099865 1688 3513030 SGTC_1188 1403-0014 4.57 µM 0.414664163312697 0.360541056907987 no 1194 0.339193885070223 1597 9614867 SGTC_863 0466-0191 129 µM 0.411750873897858 0.361496503312795 no 1195 0.340261016106287 1702 765160 YPR165W RHO1 SGTC_1885 st057546 99.9 µM 0.41092049757284 0.361768993227519 no 1196 0.340565415891816 1682 702008 SGTC_2803 7707263 71.43 µM 0.404398318424735 0.363911689212065 no 1197 0.342959918278903 1587 2199229 SGTC_2435 5706476 10.6 µM 0.403406248007928 0.364237983815848 no 1198 0.343324695565898 1754 5725375 SGTC_2996 9066192 71.4286 µM 0.400954551338692 0.365044775126942 no 1199 0.34422679279029 1532 6472854 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.400875505210045 0.36507079717335 no 1200 0.344255892454229 1600 688803 SGTC_3337 9144342 33.5465 µM 0.399479974276056 0.365530309254274 no 1201 0.344769788246762 1694 17682949 SGTC_2211 7117706 200 µM 0.398597269691511 0.365821060663341 no 1202 0.345094986860338 1699 822771 SGTC_3336 9143619 71.43 µM 0.39673942703361 0.36643326156567 no 1203 0.345779811305022 1685 45595730 SGTC_2987 9018338 71.43 µM 0.395575790525779 0.366816879238245 no 1204 0.34620899983867 1645 5055682 SGTC_768 0384-0033 77.3 µM 0.394708118062233 0.367103012648388 no 1205 0.346529155447631 1597 3965305 YMR134W ERG29 SGTC_2778 tioconazole 65.09 nM 0.394426920433087 0.367195759383363 no 1206 0.346632935878854 1582 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2385 9074692 200 µM 0.392651770816278 0.36778143137448 no 1207 0.347288348332101 1599 17046906 SGTC_814 3342-0569 96 µM 0.392026496657643 0.367987800296331 no 1208 0.347519318061981 1652 4346283 SGTC_2025 5147754 141 µM 0.390427972547275 0.368515559100627 no 1209 0.34811005337465 1724 315777 YLR208W SEC13 SGTC_3289 9119912 71.43 µM 0.390282255520631 0.368563680485397 no 1210 0.348163921529051 1653 17014829 SGTC_1343 1487-0095 224 µM 0.387660501283832 0.369429836410513 no 1211 0.349133644841444 1753 4560101 YGL055W OLE1 SGTC_2605 digitonin 300 nM 0.385954680129425 0.369993749486376 no 1212 0.349765116585643 1748 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_583 1488-1091 88.9 µM 0.384667387049868 0.370419490092189 no 1213 0.350241930365677 1760 4303273 SGTC_22 0964-0034 14.468 µM 0.384196367110052 0.370575308084341 no 1214 0.350416455357856 1621 138402 SGTC_1770 st043884 66.3 µM 0.383616081571411 0.37076730139395 no 1215 0.350631509485019 1644 670149 SGTC_257 daunorubicin 18.5 µM 0.382637923160516 0.371091007772989 no 1216 0.35099412384997 1774 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3116 9124943 49.47 µM 0.382009771247396 0.371298933042029 no 1217 0.351227058450041 1562 41905195 YPL160W CDC60 SGTC_1562 morin hydrate 59.1 µM 0.380402915936857 0.371830990858458 no 1218 0.35182317521446 1681 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1754 st042065 16.137 µM 0.380077791061685 0.371938675194122 no 1219 0.351943835548282 1631 1126236 YIL048W NEO1 SGTC_2678 equilin 100 µM 0.379956601454268 0.371978816865323 no 1220 0.351988815247258 1750 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1133 3473-0247 50 µM 0.379402650060236 0.372162320068619 no 1221 0.352194441475197 1582 711311 SGTC_3332 9141069 11.198 µM 0.377586478237014 0.372764152739412 no 1222 0.352868905577139 1603 17332883 SGTC_3156 9099931 49.47 µM 0.375804656301728 0.37335490473519 no 1223 0.353531062953969 1687 18111053 SGTC_574 1315-0397 40 µM 0.374852316653628 0.373670769237828 no 1224 0.353885151652414 1645 6794277 SGTC_1802 st050112 57.9 µM 0.374796957199681 0.373689133037146 no 1225 0.353905738700823 1657 4662563 SGTC_3040 9091894 49.47 µM 0.37334819015786 0.374169818865717 no 1226 0.354444657228067 1726 25236966 SGTC_2950 9072895 21.46 µM 0.372635635375622 0.374406308970936 no 1227 0.354709823418102 1608 17332245 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.372285173722821 0.374522641179285 no 1228 0.354840268117724 1708 279621 SGTC_185 k048-0037 25.491 µM 0.369967009872036 0.375292419472956 no 1229 0.35570353569119 1797 6827589 SGTC_1777 st045864 34.765 µM 0.369326152251757 0.375505312886065 no 1230 0.355942317324369 1678 4691462 SGTC_807 1315-0151 48 µM 0.367808951187333 0.376009479324323 no 1231 0.356507847058943 1809 4011080 SGTC_2401 5128683 200 µM 0.367280554083411 0.376185115613084 no 1232 0.356704878827201 1578 708373 SGTC_2058 5236698 133 µM 0.367192133793808 0.376214508536378 no 1233 0.356737853232517 1674 766665 SGTC_3164 9100705 49.47 µM 0.365641353050819 0.376730140047038 no 1234 0.357316356707421 1758 17174235 SGTC_2929 9013348 24.6 µM 0.365536498897411 0.37676501179424 no 1235 0.357355483372443 1675 2995952 SGTC_779 1360-0071 233 µM 0.365534399050238 0.376765710158724 no 1236 0.357356266952497 1842 7566 SGTC_1090 efavirenz 20.7 µM 0.365245647592685 0.376861746588028 no 1237 0.357464023321772 1732 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1950 st077106 7.18 µM 0.365155402358917 0.376891762995325 no 1238 0.357497703400913 1641 13831864 SGTC_554 4483-2211 187 µM 0.363533144888587 0.377431467725052 no 1239 0.358103328989944 1691 747107 SGTC_487 nimodipine 119 µM 0.362952174783915 0.377624807484687 no 1240 0.358320305291943 1759 4497 L-type voltage-gated calcium channels inhibitor SGTC_890 0929-0006 47.2 µM 0.361433277975734 0.378130422583984 no 1241 0.358887787367536 1631 1378169 SGTC_41 0478-0632 82.643 µM 0.360182087261316 0.378547079727465 no 1242 0.35935548465574 1840 3750424 SGTC_3020 9089140 49.47 µM 0.358364923165574 0.379152462214603 no 1243 0.360035119049178 1678 17217859 SGTC_3027 9089541 49.47 µM 0.358109596013666 0.379237547441052 no 1244 0.360130649033378 1682 9943819 SGTC_1961 st076550 68.7 µM 0.358044549179957 0.379259224584748 no 1245 0.360154987531967 1704 1579337 SGTC_1250 0485-0349 40.2 µM 0.356826583972545 0.379665186887711 no 1246 0.360610816743513 1665 6842794 YDL195W SEC31 SGTC_42 0133-0086 60.653 µM 0.356744597189789 0.379692518829465 no 1247 0.360641507807475 1589 162923 Model of phenazepam hydroxylation. SGTC_1339 1486-1321 22.7 µM 0.356075348969157 0.37991564864212 no 1248 0.360892068816456 1673 3469382 SGTC_310 1273-0058 1.06 µM 0.355771025049569 0.380017124582209 no 1249 0.361006024936796 1710 2734232 SGTC_1227 3909-8010 46.6 µM 0.354557806131316 0.380421751006004 no 1250 0.36146044540076 1698 15982272 SGTC_776 4476-4378 112 µM 0.353602650947043 0.380740401463994 no 1251 0.361818343695569 1680 2892008 SGTC_2096 5468907 200 µM 0.352806111193208 0.381006197925892 no 1252 0.362116900977895 1826 759785 SGTC_3087 9117406 49.47 µM 0.35137555079909 0.38148370094613 no 1253 0.36265331105938 1688 42546093 SGTC_1154 4088-0362 150 µM 0.35036922612156 0.381819707592462 no 1254 0.363030809241452 1669 6618304 SGTC_864 0469-0573 172 µM 0.349839026080878 0.381996774502626 no 1255 0.363229754435012 1672 689425 SGTC_3022 9087993 49.47 µM 0.348510242983461 0.382440646563699 no 1256 0.36372851132246 1756 17173644 SGTC_2023 5144124 124 µM 0.347741448660069 0.382697528312058 no 1257 0.36401718275127 1675 2830192 SGTC_3042 9091578 49.47 µM 0.347599345247396 0.382745015812539 no 1258 0.364070549035464 1726 25236497 SGTC_447 ml7 120 µM 0.347589345379244 0.382748357591389 no 1259 0.364074304539325 1781 4216 Selective myosin light chain kinase inhibitor. SGTC_1033 k072-0102 21.3 µM 0.347523919433972 0.38277022199906 no 1260 0.364098875924381 1811 5965931 SGTC_1057 3448-5381 134 µM 0.34725160625242 0.382861229151254 no 1261 0.364201151934667 1804 5497911 SGTC_1143 3454-2408 5.08 µM 0.345034999961847 0.38360225984558 no 1262 0.365034029208295 1713 X1143 SGTC_999 SEC7.066 22.7 µM 0.343455180750508 0.384130667240016 no 1263 0.365628026482386 1762 740511 YDR170C SEC7 SGTC_2665 lovastatin 100 µM 0.342243554943639 0.384536069796278 no 1264 0.366083804982917 1713 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2010 4012422 159 µM 0.341755938097122 0.384699259069767 no 1265 0.366267285684158 1757 952393 SGTC_1742 st038235 28.8875 µM 0.34103566992183 0.384940346439776 no 1266 0.366538364471967 1712 564103 YBR002C RER2 SGTC_1008 4106-0037 6 µM 0.340245535013719 0.385204870696275 no 1267 0.366835814766676 1731 2905394 SGTC_3058 9093861 49.47 µM 0.338492712179749 0.385791877689765 no 1268 0.367495959080107 1741 17217477 SGTC_138 0850-0259 40.9225 µM 0.338467553802537 0.385800304946074 no 1269 0.367505437029628 1722 6813004 SGTC_1971 st069429 63.5 µM 0.337820596250519 0.386017033655908 no 1270 0.367749193932407 1835 1246522 YGL099W LSG1 SGTC_3062 9077494 49.47 µM 0.337587325199308 0.386095187442022 no 1271 0.367837097515716 1785 16459633 SGTC_13 0199-0087 65 µM 0.337483473850232 0.38612998268563 no 1272 0.367876234070464 1765 4589825 SGTC_1989 st071868 50.2 µM 0.336418438030158 0.386486874204369 no 1273 0.368277673701291 1854 16414057 SGTC_477 mead ethanolamide 10 µM 0.335970588319132 0.386636976509651 no 1274 0.368446522864958 1712 16061185 SGTC_828 2074-0507 139 µM 0.335831630287499 0.386683553441524 no 1275 0.36849891825679 1819 X828 SGTC_590 k048-0076 22.4 µM 0.334683966268408 0.387068297906185 no 1276 0.368931748840663 1810 6832814 SGTC_2809 7964133 12.99 µM 0.331057259142064 0.388284848036771 no 1277 0.370300617586728 1751 1253665 SGTC_420 mitomycin C 81.9 mM 0.327666983121448 0.389423081564034 no 1278 0.371581735000355 1725 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1040 k898-0338 155 µM 0.326440098866965 0.389835223712147 no 1279 0.372045701573773 1908 20969351 SGTC_1969 st069479 40.1 µM 0.325034568535148 0.390307529947932 no 1280 0.372577454500941 1823 3895485 SGTC_3169 9102970 49.47 µM 0.322689533459505 0.391095902075948 no 1281 0.373465189777048 1778 17027839 SGTC_2305 7443522 69.23 µM 0.322039708023186 0.391314444803631 no 1282 0.373711306459894 1813 5415886 SGTC_1205 4161-2785 76 µM 0.321320331139782 0.391556418391289 no 1283 0.37398382532121 1655 3498106 SGTC_438 sphingosine 6.67 µM 0.319958770389838 0.392014515307816 no 1284 0.374499792660598 1588 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1715 st032160 10.2275 µM 0.319101325383646 0.392303079433104 no 1285 0.374824839325976 1838 5289825 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.318971411741087 0.392346805677987 no 1286 0.374874095725839 1788 6708630 An antioxidant. SGTC_1628 st004252 77.7 µM 0.317876802792461 0.392715282329969 no 1287 0.37528919467346 1853 692968 SGTC_1139 k015-0024 46.9 µM 0.316322545985675 0.393238654752126 no 1288 0.37587884992525 1883 2766652 SGTC_1217 1183-1422 255 µM 0.316046855635899 0.393331509479447 no 1289 0.375983471877298 1835 2849664 SGTC_568 1193-0097 7.48 µM 0.313451236207008 0.394206031787628 no 1290 0.376968931545922 1802 3646150 SGTC_3167 9103034 49.47 µM 0.311617184032813 0.394824287052801 no 1291 0.377665736562385 1779 5127859 SGTC_33 0986-0033 35.816 µM 0.31061210795139 0.395163208644457 no 1292 0.378047760697615 1793 2848082 SGTC_475 α-linolenic acid 10 µM 0.309925734728616 0.395394706081853 no 1293 0.378308716116427 1839 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2084 5306078 60.6385 µM 0.309071446081345 0.395682888978864 no 1294 0.37863358961835 1830 679340 SGTC_3098 9119039 49.47 µM 0.309061770702183 0.39568615316612 no 1295 0.378637269515527 1758 17161528 SGTC_1176 0848-0131 83.3 µM 0.308324106026237 0.395935040975307 no 1296 0.378917862491137 1921 6769040 SGTC_1105 epirubicin 18.1 µM 0.307600414832207 0.396179255371959 no 1297 0.379193202256079 1718 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_458 nppb 133 µM 0.307559332072176 0.396193120245161 no 1298 0.379208834682083 1930 4549 A chloride channel blocker. SGTC_2193 5925765 200 µM 0.3070227293634 0.396374228418776 no 1299 0.379413035835293 1847 877370 SGTC_2824 7998404 51.95 µM 0.306517720489478 0.396544693820872 no 1300 0.379605244864374 1792 837851 SGTC_1600 coumarin 106 71.1 µM 0.305205076467142 0.396987868349597 no 1301 0.380104983145647 1812 100336 A hepatotoxic, DNA x-linker. SGTC_466 geldanamycin 89.2 µM 0.30264637908879 0.397852117084383 no 1302 0.381079682790125 1896 5288382 HSP90 inhibitor. SGTC_2773 thioridazine 9.09 µM 0.301028565062384 0.398398823638505 no 1303 0.381696356214936 1822 5452 An antipsychotic. SGTC_2203 7227154 166.4 µM 0.300941645025446 0.398428202110661 no 1304 0.38172949664636 1784 896304 SGTC_2638 epoxomicin 18 µM 0.300835808275836 0.398463975100045 no 1305 0.381769850716575 1884 9915668 A protesome inhibitor. SGTC_469 w7 172 µM 0.300587893810222 0.39854777392265 no 1306 0.381864382059035 1829 45115570 A P450 inhibitor. SGTC_2749 bexarotene 57.39 µM 0.299930923301634 0.39876986246153 no 1307 0.382114923095091 1709 82146 An retinoic acid receptor inhibitor. SGTC_1344 1488-0097 29.1 µM 0.299651187643153 0.398864436910477 no 1308 0.382221617551898 1810 747966 SGTC_2866 9034245 58.44 µM 0.299061129943301 0.399063946074583 no 1309 0.382446701790778 1901 6462273 SGTC_1012 4112-3522 18 µM 0.297000313506515 0.399760951892882 no 1310 0.383233134893395 1889 3112398 SGTC_1723 st034307 2.5525 µM 0.295409298634779 0.400299280922566 no 1311 0.383840615409664 1751 867466 SGTC_2783 7738165 71.43 µM 0.295086542328539 0.40040851052495 no 1312 0.383963884952656 1679 17201110 SGTC_3354 9151612 71.43 µM 0.294828925130638 0.400495700853825 no 1313 0.384062284498237 1909 27261949 SGTC_3113 9123498 49.47 µM 0.29457639372247 0.400581174714103 no 1314 0.384158748728174 1883 8897275 SGTC_3322 9139058 2.11 µM 0.294234572201938 0.40069687802392 no 1315 0.384289332232131 1844 4908926 YPR165W RHO1 SGTC_3163 9099914 49.47 µM 0.294149368924988 0.400725719873829 no 1316 0.384321883844537 1856 16268368 SGTC_1608 st001473 40.5 µM 0.294145757319156 0.400726942437279 no 1317 0.384323263663873 1724 7292267 SGTC_225 nsc-122657 1.016 µM 0.293693396406848 0.400880078658942 no 1318 0.38449610040222 1843 275685 SGTC_2960 9079389 5.97 µM 0.29215294343118 0.401401677158036 no 1319 0.385084844238945 1913 16457355 SGTC_641 4092-0595 30 µM 0.291878613174872 0.401494584044551 no 1320 0.385189718021072 1865 786260 SGTC_1846 st056244 14.8 µM 0.291864251844169 0.401499447921519 no 1321 0.385195208449152 1839 5393182 SGTC_120 rhodamine 6G 52.259 µM 0.291473042504098 0.40163194806407 no 1322 0.385344779116794 1759 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2611 pyromycin 23.93 µM 0.291068542465153 0.40176896157521 no 1323 0.385499449138603 1721 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_939 1165-0479 45.3 µM 0.291061788130779 0.401771249526898 no 1324 0.385502031970496 1922 1377347 SGTC_1494 4358-1428 177 µM 0.290630097733331 0.401917486575446 no 1325 0.385667119272523 1944 1564571 SGTC_2304 7443016 91.4 µM 0.289033499599441 0.402458460487223 no 1326 0.386277871044931 1777 939854 SGTC_364 0083-0097 67.7 µM 0.288796255218703 0.402538861757791 no 1327 0.38636864898576 1788 5207356 SGTC_2683 piperine 63.03 µM 0.288380004250414 0.402679937679585 no 1328 0.386527936091976 1818 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_614 0462-0418 107 µM 0.28810304410948 0.402773812128736 no 1329 0.386633931256569 1818 5188303 SGTC_916 4466-0038 42 nM 0.288011170615219 0.402804953493054 no 1330 0.386669093946887 1969 5722064 YGL116W CDC20 SGTC_1524 corynanthine 62.1 µM 0.28779706124321 0.40287753022301 no 1331 0.386751043515707 1837 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_3349 9149703 23.001 µM 0.287617405689114 0.402938430712304 no 1332 0.386819809909875 1792 4910494 SGTC_3241 9133421 49.47 µM 0.284943730282325 0.40384504336349 no 1333 0.387843626085206 1826 17018221 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.2847705767131 0.403903775622947 no 1334 0.387909957827538 1977 551469 SGTC_1951 sophoraflavanone G 9.2 µM 0.284740755680059 0.403913890889597 no 1335 0.387921382011668 1747 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1574 spiramycin 23.7 µM 0.284480836129431 0.404002058079242 no 1336 0.388020959087335 1772 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3233 9132340 49.47 µM 0.283279909004379 0.404409487267014 no 1337 0.388481138536486 1764 17682950 SGTC_1877 wortmannin 25 µM 0.282585589934646 0.404645090819311 no 1338 0.388747263926161 1914 312145 A covalent inhibitor of PI 3-kinase. SGTC_761 k216-0224 480 µM 0.281573304228811 0.404988652044288 no 1339 0.389135356206894 1981 1340404 SGTC_2207 7258803 200 µM 0.281556277003125 0.404994431568067 no 1340 0.389141885088608 1877 3666799 SGTC_1914 st062367 72.6 µM 0.280185085826672 0.405459920700323 no 1341 0.389667754196632 1774 978205 SGTC_1899 st063254 59.6 µM 0.279744351938621 0.40560956855995 no 1342 0.389836824158073 1734 3093813 SGTC_2431 5490079 200 µM 0.27940518565093 0.405724739304055 no 1343 0.389966945959775 1774 5722345 SGTC_3211 9128781 49.47 µM 0.278940464606797 0.405882557944723 no 1344 0.390145257107612 1725 17194361 SGTC_139 0099-0334 718.624 µM 0.278493511679479 0.406034356988288 no 1345 0.390316772525096 1947 97690 SGTC_334 1502-1024 68.5 µM 0.277237087779771 0.406461153027887 no 1346 0.390799031679142 1840 3296216 SGTC_276 colchicine 750 µM 0.27721046906867 0.40647019637176 no 1347 0.390809250685435 1841 2833 A microtubule depolymerizer. SGTC_2075 5212009 200 µM 0.275555355895539 0.407032596288665 no 1348 0.391444801642896 1909 780898 SGTC_2617 dihydrotanshinone i 20.83 µM 0.273342704568408 0.407784744462107 no 1349 0.392294895627978 1790 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2008 4012253 172 µM 0.272367138577413 0.408116477488443 no 1350 0.392669868743753 1797 603940 SGTC_2603 homopterocarpin 100 µM 0.269814495406422 0.408984793464478 no 1351 0.393651485279224 1811 101795 A weak amylase inhibitor. SGTC_1505 k297-0037 20.6 µM 0.269290591225438 0.409163061938461 no 1352 0.393853035981971 1780 4089396 SGTC_1334 1486-0610 236 µM 0.265742103873615 0.4103709958125 no 1353 0.395218917329586 1884 3742339 SGTC_2354 9060492 162 µM 0.264453861224685 0.410809735166423 no 1354 0.395715106483774 1927 6471895 SGTC_2966 9084041 48.03 µM 0.263638132642402 0.411087607215752 no 1355 0.396029386065257 1652 17741380 SGTC_3306 9127676 59.7925 µM 0.260302962594099 0.412224171502966 no 1356 0.397315043767935 1827 41905287 SGTC_2972 9093619 59.92 µM 0.259755700560515 0.412410738885606 no 1357 0.397526112020675 1760 25236256 SGTC_608 k048-0125 159 µM 0.258230721824787 0.412930724471531 no 1358 0.398114424585699 1952 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2908 7930301 100 µM 0.258146679517531 0.412959385576713 no 1359 0.398146853521153 1828 2223178 SGTC_2546 rhodinyl acetate 100 µM 0.255919199435736 0.413719195928035 no 1360 0.399006614591165 1985 6708682 SGTC_1479 0549-0158 134 µM 0.253765049458836 0.414454300243668 no 1361 0.39983853811178 1840 5440202 SGTC_1881 5652484 16 µM 0.252787326741397 0.414788047460735 no 1362 0.40021628075497 1971 2255129 SGTC_1692 fluoroquinolonic acid 71 µM 0.251814655447748 0.415120131408279 no 1363 0.400592164434375 1911 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2085 5307070 144.047 µM 0.25079361774611 0.415468793590736 no 1364 0.400986838109776 1801 2840351 SGTC_2753 fluvastatin 17.09 µM 0.250703891102892 0.415499436475066 no 1365 0.401021526038407 1875 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1707 st032323 6.317 µM 0.248819499010676 0.416143100775831 no 1366 0.40175020366883 1893 3132057 YMR211W DML1 SGTC_2292 7671323 168.05 µM 0.24822950184394 0.416344676348447 no 1367 0.401978420678773 1850 937504 SGTC_1408 3909-7976 48.8 µM 0.245580164765068 0.417250106528302 no 1368 0.403003622655454 1895 24152374 SGTC_2067 5224629 34.075 µM 0.244636347950042 0.417572769079577 no 1369 0.403369008717439 1813 2835000 SGTC_2278 7948257 134.34 µM 0.243815414681981 0.417853466591108 no 1370 0.403686890679281 2037 1247028 SGTC_632 0781-2353 4.65 µM 0.243211662769601 0.418059931111621 no 1371 0.403920716247682 1918 6811515 YHR007C ERG11 SGTC_1726 st035556 14.5795 µM 0.242864332667613 0.418178717523564 no 1372 0.404055248418436 1967 5919439 SGTC_3318 9139014 38.6185 µM 0.241596066975249 0.418612525931848 no 1373 0.404546584962342 1870 16643984 SGTC_798 1287-0182 476 µM 0.240644941538357 0.418937921974742 no 1374 0.40491515760996 2009 1649755 SGTC_1539 benzyladenosine 56 µM 0.239715925345798 0.419255807618932 no 1375 0.405275244110318 1879 92208 A nucleotide analog. SGTC_215 1287-0124 461.5 µM 0.238469492570216 0.419682387891475 no 1376 0.405758487150073 2013 5560863 SGTC_1469 k284-2957 126 µM 0.237751065245934 0.419928306022235 no 1377 0.406037087340602 1935 23884841 SGTC_970 1315-0089 19.5 µM 0.237545774450476 0.419998582940499 no 1378 0.406116706166237 1890 6811083 YLR033W RSC58 SGTC_2124 5246320 200 µM 0.236347703806923 0.420408767646938 no 1379 0.40658143648449 1904 579342 SGTC_1231 0242-0792 125 µM 0.236181507711749 0.420465675216671 no 1380 0.40664591418085 1838 3707635 SGTC_1462 k081-0014 26.5 µM 0.235901753692389 0.420561470158214 no 1381 0.406754453701554 1883 3270634 SGTC_3228 9131799 49.47 µM 0.235826479426451 0.42058724679838 no 1382 0.406783659984293 1907 17015818 SGTC_2505 galangin 7.89 µM 0.235654809356818 0.420646034133365 no 1383 0.406850269608507 1818 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_887 0885-0007 9.62 µM 0.235330178027097 0.420757206926002 no 1384 0.406976237024933 1958 5719458 SGTC_1438 4092-1045 4 µM 0.232118094994624 0.421857551672355 no 1385 0.408223145441322 1893 1351342 SGTC_2912 7964298 10.93 µM 0.23099429941934 0.422242668401032 no 1386 0.40865961534432 1851 2975850 SGTC_268 camptothecin 39.6153 µM 0.23095086036759 0.422257556149212 no 1387 0.408676488874741 1901 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2706 st078239 82.5 µM 0.227824657485141 0.423329281533901 no 1388 0.40989127841093 1961 15434492 SGTC_354 2783-3500 4.88 µM 0.227175588697665 0.423551866812641 no 1389 0.410143604435133 1822 6740761 SGTC_785 1270-0111 65.3 µM 0.225783374313576 0.424029381347578 no 1390 0.410684954290724 1960 6741994 SGTC_796 1234-0020 70.7 µM 0.225484591346784 0.424131875250107 no 1391 0.410801155536162 1895 46495034 SGTC_1428 4049-0204 61.7 µM 0.223687887516554 0.424748320857756 no 1392 0.411500085756461 2003 X1428 SGTC_1520 flindersine 88 µM 0.222633470635706 0.425110175063253 no 1393 0.411910392178738 2031 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_247 mechlorethamine 29.705 µM 0.221706935482375 0.425428194986639 no 1394 0.412271015369503 1934 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_3321 9137793 26.8275 µM 0.220765071270288 0.425751526123959 no 1395 0.412637680823454 2010 4904192 SGTC_209 4077-0173 175.592 µM 0.219287288044467 0.426258932635485 no 1396 0.413213131801972 1947 15993494 SGTC_3171 9103192 49.47 µM 0.218125116008715 0.426658057794315 no 1397 0.41366581438931 2059 13018434 SGTC_1285 0929-0069 65.5 µM 0.217609630824089 0.426835115127408 no 1398 0.413866640000064 1924 1206237 SGTC_666 0272-0154 136 µM 0.217411329418123 0.426903231038876 no 1399 0.413943901377553 1933 6870312 SGTC_2698 st077697 67.5 µM 0.217182148768486 0.426981956589004 no 1400 0.414033197948144 1837 3154499 SGTC_1411 3909-8223 150 µM 0.216895393346566 0.427080463670946 no 1401 0.414144933866294 2030 X1411 SGTC_2119 5528445 120.635 µM 0.216739808031729 0.427133912707921 no 1402 0.414205561498096 2017 791935 SGTC_1273 0849-0096 14.1 µM 0.215201568849865 0.427662423898592 no 1403 0.41480508390905 1906 5286025 SGTC_2832 7992762 51.95 µM 0.214989686024515 0.427735233203438 no 1404 0.414887679955187 1720 2985177 SGTC_1891 st059073 26.2 µM 0.214148154429219 0.428024433016311 no 1405 0.415215762450615 2061 688754 SGTC_321 4534-3890 65.3 µM 0.212388360506652 0.428629326637724 no 1406 0.415902032810382 2035 699746 SGTC_609 0986-0026 86.3 µM 0.211256162804669 0.42901858547562 no 1407 0.416343693966262 1956 2848610 SGTC_2477 5967686 25.23 µM 0.208533561037569 0.429954920189251 no 1408 0.417406190330758 1905 776118 SGTC_2481 5478948 45.16 µM 0.207981267475014 0.430144908679443 no 1409 0.417621796963027 1901 77792 SGTC_3220 9131269 49.47 µM 0.206912954456513 0.430512453264504 no 1410 0.41803891962603 2004 17722206 SGTC_1987 st072290 61.9 µM 0.20685302825809 0.430533072182032 no 1411 0.418062320537175 1941 54697379 SGTC_2489 cantharidin 73.42 µM 0.206671560088116 0.430595511424578 no 1412 0.418133184810813 1899 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2768 sulfasalazine 50.2 µM 0.206363040500378 0.430701670273041 no 1413 0.418253669429634 2051 5384001 An antioxidant and salicylic acid derivative. SGTC_1135 dihydrocapsaicin 536.708 nM 0.205904909769089 0.43085931822371 no 1414 0.418432595093416 1820 107982 A Capsaicinoid. SGTC_899 1083-0020 478 µM 0.205903755062931 0.43085971558505 no 1415 0.418433046092068 2023 767123 SGTC_572 0960-0087 17.7 µM 0.205852788206955 0.430877254539503 no 1416 0.418452952547525 1904 6796365 SGTC_2724 maprotiline 69.64 µM 0.205612384759108 0.430959985143428 no 1417 0.418546851296259 2016 4011 A tricyclic antidepressant. SGTC_2231 micatex 6.853 µM 0.205072076905149 0.431145933606739 no 1418 0.418757906096449 1988 20737 An antifungal of unknown mechanism. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.202463950724134 0.432043741480384 no 1419 0.419777018971575 1918 688788 SGTC_1985 st071382 65.5 µM 0.201563823426046 0.43235367837404 no 1420 0.420128864705897 1945 6123237 SGTC_496 calpeptin 138 µM 0.201123234882276 0.432505399487109 no 1421 0.420301107191374 1923 73364 A calpain inhibitor. SGTC_983 1491-0821 12.2 µM 0.200233137995042 0.432811943676864 no 1422 0.420649125777488 2050 46495113 SGTC_1878 temozolomide 1 mM 0.19958717733333 0.433034434103962 no 1423 0.420901728508453 2091 5394 DNA alkylating agent. SGTC_2323 6148992 148.28 µM 0.19888663660261 0.433275747722849 no 1424 0.421175711569617 1912 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3057 9095946 49.47 µM 0.198190045768269 0.433515725399979 no 1425 0.421448187671583 2012 24540043 SGTC_1763 st044482 94.5 µM 0.197583692515286 0.433724635912387 no 1426 0.421685397378104 2003 88505 SGTC_1695 st026914 34.495 µM 0.1973479189764 0.433805873382574 no 1427 0.421777641342639 1927 3289191 SGTC_3030 9087619 49.47 µM 0.197269841275671 0.433832776232926 no 1428 0.421808189383771 1940 25236973 SGTC_1199 1638-0010 4.46 µM 0.196095374409916 0.434237493434358 no 1429 0.422267758331392 1897 3111136 SGTC_2176 5809774 33.9695 µM 0.195928791783436 0.434294902820897 no 1430 0.422332950707992 2089 2870539 SGTC_920 mycophenolic acid 780.421 nM 0.195130079194935 0.434570182446322 no 1431 0.422645557682242 1912 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.194514068312206 0.434782514843486 no 1432 0.422886690588931 2016 5377381 SGTC_254 nsc-64875 3.808 µM 0.193912780740445 0.434989790414725 no 1433 0.423122088032318 2063 56993 SGTC_5 0352-0601 109.883 µM 0.192879412846457 0.435346054220158 no 1434 0.423526704225197 1988 762456 SGTC_787 4152-0075 138 µM 0.192811976722794 0.435369305318441 no 1435 0.423553111712222 1937 9566539 SGTC_2215 7188065 200 µM 0.192260337146959 0.4355595118517 no 1436 0.423769142570399 2050 940217 SGTC_2172 5754775 163.918 µM 0.191951425954784 0.435666031621661 no 1437 0.423890127133493 1911 2263357 SGTC_3240 9133527 49.47 µM 0.191821748240116 0.435710748907749 no 1438 0.423940917336886 1967 17617455 SGTC_2781 5567276 71.43 µM 0.191705070750381 0.435750983976686 no 1439 0.423986616888864 2017 2853274 SGTC_2224 6650123 117.647 µM 0.190906247183864 0.436026468159489 no 1440 0.424299522823517 1985 2908370 SGTC_2192 5915882 198.485 µM 0.19055520872776 0.436147537936168 no 1441 0.424437042654986 2008 2876149 SGTC_712 r015-0009 80.6 µM 0.190182398491512 0.436276123140767 no 1442 0.42458310168581 2019 6813872 YLR060W FRS1 SGTC_1376 2910-0861 41.3 µM 0.188764104033867 0.436765365571845 no 1443 0.425138853419319 2010 1112859 SGTC_2610 ononetin 44.17 µM 0.187548002512073 0.437184938362236 no 1444 0.425615495380963 1934 259632 SGTC_2356 9061756 188.97 µM 0.186801567463663 0.437442504382835 no 1445 0.42590810894644 2081 20104043 SGTC_2284 7945075 39.21 µM 0.186476560089984 0.437554660216322 no 1446 0.426035529398287 2096 1245402 SGTC_794 k038-0031 316 µM 0.186299806860679 0.437615657572498 no 1447 0.426104829457673 2013 6624242 SGTC_3262 9137218 49.47 µM 0.185960145580585 0.437732878488879 no 1448 0.426238007668741 2046 17650664 SGTC_1001 4048-4355 44.4 µM 0.183702887653353 0.438512021860057 no 1449 0.427123271722256 1968 21824233 SGTC_1228 0124-0032 52.5 µM 0.183067252831059 0.438731468666391 no 1450 0.427372624987813 2054 X1228 SGTC_2877 9040724 71.43 µM 0.180179272833356 0.439728752193513 no 1451 0.428505915003696 2130 6463895 SGTC_2269 7935389 174.42 µM 0.179811652097797 0.439855727366054 no 1452 0.428650217833323 1906 97605 SGTC_3313 9133968 57.047 µM 0.178803817661639 0.440203862249343 no 1453 0.429045873767003 2037 1494643 SGTC_396 dithiazanine 1.25 µM 0.17849959058443 0.440308960092898 no 1454 0.429165321349439 1935 10578 An antihelmenthic. SGTC_674 0498-0004 451 µM 0.177521775069948 0.440646783262756 no 1455 0.429549281411973 1933 4231473 SGTC_702 1488-0190 94 µM 0.177285138924185 0.440728544627149 no 1456 0.429642211659277 2124 949357 SGTC_2640 pentamidine 10.38 µM 0.177232610159347 0.440746694452039 no 1457 0.429662840951814 2118 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3272 9137413 49.47 µM 0.176796828771793 0.440897271147212 no 1458 0.429833990044998 2114 17614870 SGTC_2183 6420625 130.508 µM 0.176598633869487 0.440965756784173 no 1459 0.429911833616754 2053 2897619 SGTC_3231 9132313 49.47 µM 0.174104172146906 0.44182786061518 no 1460 0.430891797189877 2006 4905967 SGTC_1611 st001856 99.4 µM 0.17376892031726 0.441943747149047 no 1461 0.431023535371573 1933 647478 SGTC_1867 st057372 64 µM 0.173422793458186 0.44206339806893 no 1462 0.43115955497984 2105 688837 SGTC_1787 fluconazole 80 µM 0.172451692369338 0.442399121493018 no 1463 0.43154121810741 2019 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1114 scopoletin 1.73284 µM 0.171889687430065 0.442593433489037 no 1464 0.431762127078113 2112 5280460 A coumarin with genotoxic properties. SGTC_3275 9138069 49.47 µM 0.169083921713366 0.443563726599093 no 1465 0.432865315726303 2015 17617007 SGTC_1716 st033144 30.6155 µM 0.167747885362681 0.444025875530979 no 1466 0.433390811421559 2113 674617 SGTC_2670 beta-carotene 100 µM 0.166903769941927 0.444317903155936 no 1467 0.433722883387839 2090 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1930 st074634 34.3 µM 0.164552165563846 0.445131616049804 no 1468 0.434648242092653 2025 684253 YOR116C RPO31 SGTC_2088 5278280 127.392 µM 0.164335360308758 0.44520664768926 no 1469 0.434733573287739 2031 791502 SGTC_2437 5741531 144.16 µM 0.162541982109789 0.445827372369218 no 1470 0.435439535434048 2116 2262990 SGTC_3194 9111903 49.47 µM 0.162472424614231 0.445851450318642 no 1471 0.43546692085681 2052 17087251 SGTC_2386 9075165 157.42 µM 0.160791898813668 0.446433239850579 no 1472 0.436128653011767 2040 16452277 SGTC_3051 9093778 49.47 µM 0.160687897961019 0.446469248221945 no 1473 0.436169610796948 2132 17217378 SGTC_1346 1488-2224 62.4 µM 0.160661777270541 0.446478292097193 no 1474 0.436179897797378 2133 3722427 SGTC_2263 7948595 193.29 µM 0.158596199957696 0.44719355327983 no 1475 0.436993511448496 1970 2971371 SGTC_1038 k292-0204 154 µM 0.157474917207627 0.447581899395212 no 1476 0.437435287206413 2035 4454212 SGTC_1510 1123-0200 71.5 µM 0.157006205189911 0.447744248468942 no 1477 0.437619978861625 2100 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_938 3126-1755 342 µM 0.156981620347494 0.447752764230459 no 1478 0.437629666667938 2148 1777771 SGTC_1609 st001574 46.4 µM 0.154034511044241 0.448773764954587 no 1479 0.438791262209787 2015 3960012 SGTC_1122 capsaicin 818.572 nM 0.151804074843584 0.44954670640421 no 1480 0.43967073406281 2061 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1652 st011932 78 µM 0.151089333515857 0.449794435465344 no 1481 0.439952623264445 2125 1551076 SGTC_3054 9094397 49.47 µM 0.151013161756096 0.44982083772257 no 1482 0.439982666694823 2045 2598354 SGTC_517 1365-0151 113 µM 0.15055980491978 0.449977982490772 no 1483 0.440161485442528 2043 768657 SGTC_3148 9097893 49.47 µM 0.14991130309979 0.450202782998689 no 1484 0.440417296956318 1999 17174100 SGTC_2622 2-methoxyxanthone 59.94 µM 0.149896719650652 0.450207838475758 no 1485 0.440423049908382 2115 71034 A hepatoprotective. SGTC_649 1123-0311 367 µM 0.149300977020585 0.450414364638752 no 1486 0.440658072181688 2130 693629 YIL048W NEO1 SGTC_1997 st073024 93.8 µM 0.148762241105961 0.450601139840986 no 1487 0.440870623135284 2151 686268 SGTC_1956 st077085 54 µM 0.14816059765455 0.450809737485171 no 1488 0.441108013537346 2003 24208685 SGTC_1420 4'-methoxyflavone 42 µM 0.147503578952968 0.451037549970561 no 1489 0.441367277517033 2145 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2642 cholecalciferol 100 µM 0.147080896137083 0.451184118138826 no 1490 0.441534084276156 2137 9821465 A vitamin D precursor, similar to steriods. SGTC_793 0488-0545 106 µM 0.146422838517778 0.451412317375927 no 1491 0.441793799539177 1962 292548 SGTC_2334 9017922 200 µM 0.14635887651254 0.451434498784684 no 1492 0.441819044727193 2114 3163164 SGTC_1239 0337-0584 35.4 µM 0.145705657188298 0.451661037638874 no 1493 0.442076877622517 2141 914301 YML130C ERO1 SGTC_2910 7948405 25.97 µM 0.144659712037458 0.452023808001506 no 1494 0.442489774810479 2134 2971328 SGTC_1206 3978-0017 132 µM 0.144193619813112 0.452185478008988 no 1495 0.442673789474074 2058 3873677 SGTC_2641 levomentholum 100 µM 0.143961552721705 0.452265976385198 no 1496 0.442765414899757 2114 16666 SGTC_1221 2958-7315 257 µM 0.143466260215585 0.45243778775394 no 1497 0.442960978006275 2072 4562705 SGTC_636 0kpi-0074 126 µM 0.142228053583557 0.452867346525248 no 1498 0.443449936739781 2051 616434 SGTC_167 3672-0051 66.205 µM 0.140346870422897 0.453520072186002 no 1499 0.444192966759637 2114 3237971 SGTC_696 1560-0013 611 µM 0.139936198923522 0.453662582156229 no 1500 0.444355200032973 2121 1650269 SGTC_1179 1021-1431 9.29 µM 0.13983628438128 0.453697255098851 no 1501 0.444394672075182 2087 2840958 SGTC_2332 7982454 138.89 µM 0.13951981359201 0.453807081014888 no 1502 0.444519700039692 2157 2981748 SGTC_288 1315-0019 35.1 µM 0.139467128430295 0.453825364865909 no 1503 0.444540514877883 2076 6811474 SGTC_312 4092-0653 6.84 µM 0.138556056111492 0.454141558719274 no 1504 0.44490048520363 2127 1148278 SGTC_2298 7976326 193.81 µM 0.138375259438607 0.454204308898591 no 1505 0.4449719245039 2106 2235818 SGTC_2353 9059630 146.67 µM 0.138137020547661 0.454286997636323 no 1506 0.445066064029634 2128 4779114 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.136951599608153 0.454698466819652 no 1507 0.445534526224504 2064 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.136873028620033 0.454725741167003 no 1508 0.445565579102683 2056 279621 SGTC_3024 9090631 49.47 µM 0.136081885179922 0.455000382665372 no 1509 0.445878273918211 2196 25236383 SGTC_992 3909-8734 162 µM 0.13584972085468 0.455080981440869 no 1510 0.44597004190731 2044 4288319 SGTC_1174 0739-0097 51.1 µM 0.135425696874831 0.455228191487112 no 1511 0.446137654056612 2064 728447 SGTC_2720 fluspirilene 36.88 µM 0.132004001181698 0.456416338076988 no 1512 0.447490563480317 2138 3396 An atypical antipsychotic. SGTC_2887 9044784 58.44 µM 0.131356850287557 0.456641098337089 no 1513 0.447746510654141 2197 6465546 SGTC_407 eburnamonine 100 µM 0.130183573608076 0.457048621272984 no 1514 0.448210595169345 2041 3195 SGTC_2715 st079500 56.4 µM 0.13016314619198 0.457055716881027 no 1515 0.448218675775104 2094 28246688 SGTC_355 1311-2252 105 µM 0.129861261141976 0.457160580391953 no 1516 0.448338096909741 2031 5338538 SGTC_1710 st031758 61.5 µM 0.128173455531982 0.457746915327445 no 1517 0.449005853097994 2178 5394341 SGTC_2736 butenafine 14.65 µM 0.128140871540886 0.45775823574635 no 1518 0.449018745916283 2147 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1404 3909-7820 48.3 µM 0.127765365328596 0.457888697607825 no 1519 0.449167329919402 2189 23741373 SGTC_3111 9122088 49.47 µM 0.125728146611977 0.458596565809464 no 1520 0.449973560441324 2191 16876704 SGTC_2949 9072542 2.23 µM 0.124623936560855 0.458980298428142 no 1521 0.450410638747131 2086 16457352 SGTC_228 caffeine 993.056 µM 0.123371328402153 0.459415648283156 no 1522 0.450906530111595 2199 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2687 chenodiol 100 µM 0.122233789272543 0.45981104753955 no 1523 0.451356933558307 2115 5702181 A cholesterol synthesis inhibitor. SGTC_2065 5221596 34.26 µM 0.122140128723026 0.45984360495364 no 1524 0.451394020825592 2130 788581 SGTC_1197 1601-0112 267 µM 0.121554624094866 0.460047138752374 no 1525 0.45162587581922 2079 7350313 SGTC_2751 anetholtrithion 17.25 µM 0.119542271298213 0.460746754669924 no 1526 0.452422876233422 2159 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2364 9055074 200 µM 0.118869682514376 0.460980614538488 no 1527 0.452689300636892 2080 6470630 SGTC_1149 3909-7961 23.3 µM 0.116214943418402 0.461903801259118 no 1528 0.453741096932761 2039 735261 SGTC_2261 9010538 184.68 µM 0.115762883003826 0.462061026064934 no 1529 0.453920233878956 2047 6457250 SGTC_506 n9-isopropylolomoucine 153 µM 0.115269833898456 0.462232513332044 no 1530 0.454115624007002 2225 6610355 SGTC_3000 9075062 71.4286 µM 0.114969446964912 0.462336994268402 no 1531 0.454234669607761 2084 17057871 SGTC_1025 k007-0731 70 µM 0.113969485194238 0.462684820831806 no 1532 0.454630991541621 2030 6256118 SGTC_950 1165-0508 94.1 µM 0.113499198893258 0.462848415035137 no 1533 0.454817399084531 2093 6148369 SGTC_2099 5377090 177.372 µM 0.111230892066934 0.463637557983548 no 1534 0.455716627648008 2095 2243829 SGTC_108 0509-0257 621.132 µM 0.110519954328712 0.463884922509494 no 1535 0.455998512771072 2202 536624 SGTC_613 3914-0030 117 µM 0.109820166212083 0.464128421258509 no 1536 0.456275998727446 2182 1145395 SGTC_2570 licareol 100 µM 0.109412509324413 0.4642702760259 no 1537 0.456437656154469 2084 443158 SGTC_555 4296-0685 37 µM 0.108205069685951 0.464690462486381 no 1538 0.45691651177136 2223 2908540 YHR072W ERG7 SGTC_454 lyso-paf C-16 6.67 µM 0.106359770660736 0.465332698595559 no 1539 0.457648455168264 2093 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2491 paeonol 100 µM 0.105117557451191 0.465765088256788 no 1540 0.458141263828079 2104 11092 Increases levels of cortical cytochrome oxidase. SGTC_1454 4239-0054 42.6 µM 0.103314037874947 0.46639292928093 no 1541 0.458856867312868 2209 1340767 SGTC_2101 5377231 179.231 µM 0.102392993097784 0.466713595644105 no 1542 0.459222372569844 2168 2844213 SGTC_699 0375-0592 111 µM 0.102130836649262 0.466804870687123 no 1543 0.459326412437825 2262 762578 SGTC_213 1246-0773 967 nM 0.10122426780723 0.467120524299173 no 1544 0.459686216366524 2154 6251622 SGTC_1657 st012939 43.4 µM 0.101221625412015 0.467121444371695 no 1545 0.459687265142984 2212 24207257 SGTC_490 phenamil 164 µM 0.0997074124806954 0.467648716616416 no 1546 0.460288307781583 2232 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2421 5690543 90.72 µM 0.0947129551177214 0.469388260938629 no 1547 0.462271413771725 2148 3397993 SGTC_1340 1486-1359 257 µM 0.0932849382982655 0.469885740900162 no 1548 0.46283859870002 2139 4309068 SGTC_1002 4049-0206 172 µM 0.0922286321755967 0.470253757844085 no 1549 0.463258194900444 2198 4662749 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0916351959246612 0.470460522139952 no 1550 0.463493943388945 2244 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1299 1079-1439 3.74 µM 0.0911632906550413 0.470624948454889 no 1551 0.463681421633988 2183 323161 SGTC_2019 4016004 108 µM 0.0908587344332603 0.470731067873622 no 1552 0.463802419833722 2162 45595336 SGTC_439 amiodarone 34.4 µM 0.090821193999694 0.470744148587699 no 1553 0.463817334635052 2161 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2144 5628481 200 µM 0.0882102324955249 0.47165399739193 no 1554 0.464854792333242 2187 2818399 SGTC_136 0097-0015 404.482 µM 0.0857521253100556 0.47251071594415 no 1555 0.465831732345438 2259 4861337 SGTC_1815 st051655 58.2 µM 0.0854833186718898 0.47260441030161 no 1556 0.465938578348124 2269 5984156 SGTC_154 3389-1638 511.116 µM 0.0842456665811558 0.473035821719778 no 1557 0.46643055526618 2008 5238686 SGTC_3206 9114350 49.47 µM 0.0828124552139078 0.473535439202586 no 1558 0.467000332659534 2271 17087243 SGTC_1738 st035555 74 µM 0.0816659742844539 0.473935132464401 no 1559 0.467456168267937 2207 5331140 SGTC_205 1486-1330 71.903 µM 0.0814229107003976 0.474019874176869 no 1560 0.467552814748254 2248 4118834 SGTC_2149 5554786 194.827 µM 0.0812898315922623 0.474066271388817 no 1561 0.467605730220965 2179 745063 YPR165W RHO1 SGTC_60 0986-0278 202 µM 0.0812229966536198 0.474089573111539 no 1562 0.467632305625369 2037 3110598 SGTC_2344 7990960 76.95 µM 0.081000923672896 0.474166998566611 no 1563 0.467720608967759 2174 140813 SGTC_1571 st070080 73.4 µM 0.0807970727537971 0.474238071782682 no 1564 0.46780166803216 2235 4315245 SGTC_3280 9140961 49.47 µM 0.0801595415970025 0.474460354157188 no 1565 0.468055183850348 2119 4901226 SGTC_2748 diazoxide 86.69 µM 0.0801425928433078 0.474466263638693 no 1566 0.46806192374081 2235 3019 A potassium channel activatior. SGTC_880 0833-0487 87.2 µM 0.0797762633928916 0.474593992224771 no 1567 0.468207601604722 2272 76075 SGTC_2150 5556613 200 µM 0.0781970517972504 0.475144647801203 no 1568 0.468835653581664 2198 743190 SGTC_2543 pimpinellin 60.67 µM 0.0780674445198543 0.475189842708741 no 1569 0.468887201822119 2158 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1279 0874-0590 65.2 µM 0.077890887676943 0.47525140975118 no 1570 0.468957423984947 2211 3523074 SGTC_2142 5622915 118.518 µM 0.0778619873616677 0.475261487621013 no 1571 0.4689689186337 2172 5322196 SGTC_1876 myriocin 605 nM 0.0758492237806481 0.47596339983104 no 1572 0.469769526986429 2277 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1814 st052110 31.539 µM 0.0753593557898449 0.476134243149261 no 1573 0.469964398298151 2256 674163 SGTC_1934 st074720 32.6 µM 0.0740533618549955 0.476589734838302 no 1574 0.470483962580548 2262 17250992 SGTC_692 k241-0027 77.8 µM 0.0722026715815488 0.477235252592277 no 1575 0.471220309555278 2262 3600480 SGTC_123 0083-0120 66.675 µM 0.0719767550000104 0.477314056053118 no 1576 0.471310203341849 2204 16001701 SGTC_3195 9113082 49.47 µM 0.0719087608947154 0.477337773701662 no 1577 0.471337258957895 2288 17018038 SGTC_854 0422-0053 192 µM 0.0717758897900179 0.477384121924028 no 1578 0.47139013024036 2250 3596728 SGTC_1488 4013-0813 75.9 µM 0.0708556231898445 0.477705138538377 no 1579 0.471756331061288 2179 2910057 SGTC_3126 9127922 49.47 µM 0.0706279981784668 0.47778454321481 no 1580 0.471846913363196 2209 45595682 SGTC_1156 4092-0367 4.88 µM 0.0687764522852694 0.478430468704752 no 1581 0.472583781024206 2159 1357585 SGTC_2113 5491891 107.031 µM 0.0686692264766208 0.478467876973694 no 1582 0.472626457037975 2228 789979 SGTC_96 0929-0093 37.281 µM 0.0683448044227712 0.478581060462977 no 1583 0.472755579356444 2160 6991579 SGTC_736 0958-0254 92.6 µM 0.0676752874396604 0.478814645189032 no 1584 0.473022060982726 2227 6812352 SGTC_1055 3448-0672 86 µM 0.0636699406693605 0.48021220155566 no 1585 0.474616520018568 2231 748378 SGTC_2248 tofa 1.1 µM 0.0635576756301456 0.480251376960107 no 1586 0.47466121676022 2189 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_428 3448-4153 16.5 µM 0.0629346993264584 0.48046877087703 no 1587 0.474909251767062 2254 3834874 SGTC_595 3909-8003 73.7 µM 0.0623973652734236 0.480656283728089 no 1588 0.475123196540314 2242 699517 SGTC_665 3914-0008 307 µM 0.0619320254121818 0.480818676308195 no 1589 0.475308481924956 2263 1069549 SGTC_1548 st061468 90.8 µM 0.0612832201869943 0.48104509925832 no 1590 0.475566827016709 2297 390799 SGTC_1272 0839-0021 27 µM 0.0606144445664912 0.481278497965963 no 1591 0.475833134788478 2238 5027250 SGTC_481 bay k-8644 50 µM 0.0598287029509884 0.481552725302412 no 1592 0.476146032434366 2200 2303 A calcium channel antagonist. SGTC_432 NS 1619 61.3 µM 0.0591315707536416 0.481796034867845 no 1593 0.476423656401616 2176 4552 A K+/calcium channel activator. SGTC_3120 9124077 49.47 µM 0.0584451011820352 0.482035629643846 no 1594 0.476697045298791 2318 18774327 YGL155W CDC43 SGTC_1897 st060201 15 µM 0.0583167933123464 0.482080412970624 no 1595 0.476748145575208 2145 611878 SGTC_198 3454-2873 16.191 µM 0.058027215789135 0.482181485113716 no 1596 0.476863474990751 2253 710957 SGTC_3348 9149464 3.537 µM 0.0578235289345054 0.48225257925623 no 1597 0.476944598076534 2312 1951442 SGTC_2690 usnic acid 100 µM 0.0560522365082057 0.482870848476786 no 1598 0.477650096910638 2299 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1296 1068-0102 11.9 µM 0.0556456309707958 0.483012779914884 no 1599 0.477812056268788 2291 767053 SGTC_2406 ethylparaben 405.7 µM 0.0555456170553346 0.483047691523207 no 1600 0.477851894433317 2133 8434 A possible steroid mimic. SGTC_303 1348-1668 34.2 µM 0.0551393225580887 0.483189517064952 no 1601 0.478013734454668 2255 5380509 SGTC_274 sirtinol 40.1 µM 0.0551179518233874 0.483196977023271 no 1602 0.478022247198646 2169 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_516 3992-2719 87.3 µM 0.0538723826884488 0.483631782344905 no 1603 0.478518420062408 2294 5350887 YDR037W KRS1 SGTC_2934 9036370 36.88 µM 0.0531998815632396 0.483866548268637 no 1604 0.478786324991112 2282 6462800 SGTC_772 k072-0172 35.3 µM 0.0525162720420801 0.484105197795806 no 1605 0.479058665005452 2213 5861980 SGTC_2237 6667747 47.222 µM 0.0524449927985862 0.484130081859485 no 1606 0.479087062176469 2166 729940 YDL015C TSC13 SGTC_754 3474-0146 171 µM 0.0523909223464566 0.484148958259501 no 1607 0.479108603551607 2287 24762078 SGTC_2315 7733312 200 µM 0.0514909258701485 0.484463158957934 no 1608 0.479467166183945 2281 726316 SGTC_246 cycloheximide 667 µM 0.0512040310043047 0.484563319795239 no 1609 0.479581469891709 2248 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_978 1416-0512 87.4 µM 0.0504277544300066 0.484834338613431 no 1610 0.479890759840069 2250 6814003 SGTC_1314 1222-0010 41.1 µM 0.049037219619954 0.485319828767075 no 1611 0.480444817318948 2275 3526027 SGTC_2029 5175081 200 µM 0.0484404559433033 0.485528189050533 no 1612 0.480682608975667 2311 1380876 SGTC_1579 chlormadinone acetate 49.4 µM 0.0469523346939177 0.486047784285373 no 1613 0.481275608501 2322 45114258 A steroidal progestin. SGTC_24 0417-1663 219 µM 0.0465636146219133 0.486183514459927 no 1614 0.481430515941695 2267 4329390 SGTC_759 3486-0358 89.3 µM 0.0462529241450126 0.486292000034437 no 1615 0.481554330105753 2336 875103 SGTC_563 tetrahydrosecaminediol 614 µM 0.0458006915363369 0.486449910497168 no 1616 0.481734553812266 2315 334274 A psychoactive constituent of the cannabis plant. SGTC_717 1532-0246 73.2 µM 0.0439721653241115 0.487088416203196 no 1617 0.482463295626429 2284 9561992 SGTC_1267 0828-0272 9.49 µM 0.0438731137504276 0.487123005124887 no 1618 0.482502773388509 2310 745334 SGTC_823 0417-1665 178 µM 0.0435896824933266 0.487221980175072 no 1619 0.482615738029737 2270 3429856 SGTC_3257 9139206 32.98 µM 0.0435030148337381 0.487252244940712 no 1620 0.482650280656625 2318 4910041 SGTC_2416 tofa 880 nM 0.0418904531117807 0.487815372492818 no 1621 0.483293013516043 2167 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2411 st077133 39.94 µM 0.0417856392554214 0.487851975709295 no 1622 0.483334791614239 2315 1403142 YNL221C POP1 SGTC_2116 5511452 16.8835 µM 0.0416340377296535 0.487904918350905 no 1623 0.483395219286384 2292 870744 SGTC_15 0266-0086 27.098 µM 0.0411989098183166 0.488056875924729 no 1624 0.483568661387697 2326 1712902 YIL048W NEO1 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.0407207122496245 0.488223876501425 no 1625 0.483759274650817 2322 688664 SGTC_3061 glucosamine 200 µM 0.0406733089543542 0.488240431231488 no 1626 0.483778170175223 2328 91431 and experimental redox chemotherapeutic SGTC_1944 st076371 56.9 µM 0.0405328358998384 0.488289488984127 no 1627 0.483834164640348 2300 24208455 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0400308601348794 0.488464796666076 no 1628 0.484034261587373 2341 65057 A dermal irritant. YDR527W RBA50 SGTC_1146 3579-1023 7 µM 0.0395568094328573 0.488630353975662 no 1629 0.484223230773437 2328 X1146 SGTC_647 0140-0236 81 µM 0.0395369198819985 0.488637300238815 no 1630 0.484231159353818 2290 990837 SGTC_2904 7225135 42.03 µM 0.0394211829102283 0.488677720499024 no 1631 0.484277295757229 2330 4446116 SGTC_2802 7925815 54.55 µM 0.0394033387092888 0.488683952461317 no 1632 0.484284409036676 2300 1262923 SGTC_3217 9129673 49.47 µM 0.0377626075650216 0.489256977939605 no 1633 0.484938478967125 2311 17248312 SGTC_894 0960-0238 55.9 µM 0.0375988485827768 0.489314172013344 no 1634 0.485003762986068 2331 6741907 YDL195W SEC31 SGTC_2984 9022109 38.96 µM 0.0347195130532337 0.490319836747376 no 1635 0.486151700570259 2345 6459207 SGTC_2872 9044037 25.97 µM 0.0344994644739339 0.490396695666813 no 1636 0.48623943469167 2265 6465195 SGTC_1278 0874-0585 172 µM 0.0341464409414752 0.490520001034109 no 1637 0.486380187771448 2313 766306 SGTC_2528 xanthyletin 44.79 µM 0.0335875621421763 0.49071521013943 no 1638 0.486603020323011 2314 65188 An natural product with antifungal activity of unknown mechanism. SGTC_982 1491-0518 27.5 µM 0.0333882112394308 0.490784841360922 no 1639 0.486682505245395 2305 3091256 SGTC_1730 st033808 45.1 µM 0.0333726911115229 0.490790262393902 no 1640 0.486688693432046 2169 1045166 SGTC_180 1486-1293 102.781 µM 0.0333632669410744 0.490793554167784 no 1641 0.486692451039612 2353 4140536 SGTC_1134 3477-0009 42.5 µM 0.0331405328974343 0.490871353251223 no 1642 0.486781259955633 2348 3973534 SGTC_1046 2001-0062 216 µM 0.0322600172999641 0.491178913138758 no 1643 0.487132347084356 2330 739778 SGTC_2583 asiatic acid 100 µM 0.0316434565668658 0.491394277987235 no 1644 0.487378193699234 2332 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3199 9111318 49.47 µM 0.0277445516714425 0.492756222146623 no 1645 0.488932945135322 2355 8548020 SGTC_2525 harmine 47.85 µM 0.0265704704529467 0.493166363052367 no 1646 0.489401163052807 2340 5280953 A monoamine oxidase inhibitor SGTC_3234 9132280 49.47 µM 0.0240042060431927 0.494062858817062 no 1647 0.490424626868777 2291 17612295 SGTC_682 0kpi-0099 17 µM 0.0236784159504309 0.494176672180934 no 1648 0.490554561377578 2334 1714895 YML126C ERG13 SGTC_716 1683-5115 658 µM 0.0234916824963768 0.49424190692209 no 1649 0.490629036531006 2375 723597 SGTC_1207 2099-0101 141 µM 0.0230072335263531 0.494411148350095 no 1650 0.490822251478956 2360 5837381 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.021368498977568 0.494983644769383 no 1651 0.49147585099992 2350 6708760 SGTC_1747 st037496 66.6 µM 0.0207518666493786 0.495199069706995 no 1652 0.491721797154744 2361 723305 SGTC_338 4055-0136 114 µM 0.0207385277719209 0.495203729755442 no 1653 0.491727117451982 2365 2900563 SGTC_1871 st057448 67.3 µM 0.0205367663391792 0.495274216879573 no 1654 0.49180759147865 2367 691747 SGTC_3320 9137005 35.139 µM 0.0199046774453928 0.495495043617284 no 1655 0.492059706911712 2302 4908713 SGTC_1290 0986-0249 10.2 µM 0.0184582626152983 0.496000368556832 no 1656 0.492636636747842 2372 53329 SGTC_1644 st010134 20.9 µM 0.0180110424974221 0.496156612400397 no 1657 0.492815022100765 2373 3818134 SGTC_685 1278-0033 54.9 µM 0.0179491136398781 0.496178248331719 no 1658 0.492839724147211 2372 3590572 SGTC_2466 5983409 37.09 µM 0.0161071005065379 0.496821792751366 no 1659 0.493574474432787 2289 2879657 SGTC_1423 4048-0112 5.59 µM 0.0157336202783162 0.496952276660494 no 1660 0.493723452604811 2379 X1423 SGTC_2534 helenine 20.12 µM 0.01517795223854 0.497146412671793 no 1661 0.493945105600932 2381 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_980 1473-0395 201 µM 0.0142742699292315 0.497462137271697 no 1662 0.494305583581453 2374 768876 SGTC_1400 3771-8998 51.5 µM 0.0142066256296449 0.49748577060966 no 1663 0.494332567016452 2362 670767 SGTC_25 0118-0223 35.662 µM 0.0139639370438162 0.49757056040386 no 1664 0.494429376150365 2377 5333628 SGTC_2588 indole-3-carbinol 100 µM 0.0137279501102433 0.497653008900612 no 1665 0.494523512291711 2382 3712 Induces cell cycle arrest. SGTC_884 0851-0618 334 µM 0.0136496292456102 0.497680372461488 no 1666 0.494554754868743 2371 9642473 SGTC_3074 9116018 49.47 µM 0.0135908328603695 0.497700914612505 no 1667 0.494578209057144 2371 17027303 SGTC_2540 epiandrosterone 100 µM 0.0130315298714448 0.497896322950658 no 1668 0.494801318897055 2386 441302 A steroid. SGTC_2194 5927483 104.545 µM 0.0130204333019255 0.497900199856726 no 1669 0.49480574541225 2373 760979 SGTC_1328 1441-0025 69.2 µM 0.0116983196804182 0.498362119634519 no 1670 0.495333152113625 2385 4562601 SGTC_170 4197-0004 226 µM 0.0108592912621675 0.498655260384092 no 1671 0.495667854724627 2363 218692 SGTC_3085 9117376 49.47 µM 0.00975588367002029 0.499040771324773 no 1672 0.496108027259337 2321 16480349 SGTC_2393 9031399 185.94 µM 0.00870149040311966 0.499409158375974 no 1673 0.496528651381811 2380 1526623 YDL150W RPC53 SGTC_1000 4048-0884 8.67 µM 0.00854483225507866 0.499463892115615 no 1674 0.496591146616988 2379 13040088 SGTC_784 4579-0127 173 µM 0.00776364452119669 0.499736826188733 no 1675 0.496902785064199 2393 1948547 SGTC_2817 7995342 71.43 µM 0.00746713350897365 0.499840422271183 no 1676 0.497021072413109 2392 18879975 SGTC_26 0302-0163 425.158 µM 0.00701039279766209 0.5 no 1677 0.497203280818553 2384 3100915 SGTC_2623 humulene 100 µM 0.00639537828638161 0.499785124000683 no 1678 0.497448630594615 2388 6187145 An anti-inflammatory. SGTC_373 0844-0104 25.9 µM 0.00554021302339775 0.4994863433783 no 1679 0.497789786089245 2399 5375804 SGTC_105 0111-0055 734.78 µM 0.00472834556883783 0.499202690559227 no 1680 0.498113670065103 2364 5179370 SGTC_2060 5238662 140 µM 0.0042031108044537 0.499019182581761 no 1681 0.498323206327972 2391 790130 SGTC_928 2764-0428 58.7 µM 0.00406075284373113 0.498969445197075 no 1682 0.498379998452603 2356 662578 SGTC_1041 0206-0046 107 µM 0.00384176976049027 0.498892936364655 no 1683 0.498467359381064 2374 50494 SGTC_3135 9127742 49.47 µM 0.00355588185861652 0.498793052228683 no 1684 0.498581411371995 2389 3643468 SGTC_1013 4112-3890 241 µM 0 0.497550698821208 no 1685 0.5 2405 705171 SGTC_1668 st014914 51.6 µM -0.000476225746409339 0.497384316689274 no 1686 0.499810013421923 2406 2839556 SGTC_1634 st006576 41 µM -0.000778867986098883 0.497278580807285 no 1687 0.49968927666091 2408 3915356 SGTC_191 3914-0123 66.505 µM -0.00211533235422288 0.4968116548542 no 1688 0.499156105116152 2414 3144412 SGTC_3076 9116187 49.47 µM -0.00352635268840336 0.496318685735107 no 1689 0.498593191732638 2414 27241210 SGTC_2826 7992541 19.48 µM -0.0036051096622758 0.496291170517059 no 1690 0.498561772445632 2408 2985066 SGTC_1915 st067105 30.6 µM -0.0038421720623132 0.496208348452176 no 1691 0.498467198887042 2416 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3110 9122132 49.47 µM -0.00417026162180456 0.496093724662458 no 1692 0.498336311140953 2436 918317 SGTC_2531 methyl deoxycholate 70.07 µM -0.00452237773750463 0.495970707136792 no 1693 0.498195838462321 2414 16667744 Haematoxylin. SGTC_2585 alliin 100 µM -0.00485432981906976 0.495854734597 no 1694 0.498063410197964 2419 87310 A garlic compound which reacts with lipids. SGTC_733 4069-0007 56.1 µM -0.00488937671673489 0.495842490447229 no 1695 0.498049428674615 2417 5717425 YNL287W SEC21 SGTC_1868 st057644 42.7 µM -0.00559261401428762 0.495596804985268 no 1696 0.497768881442314 2422 688665 SGTC_1409 3909-8004 61.9 µM -0.00660660857890069 0.495242555233039 no 1697 0.497364363680886 2424 2119279 SGTC_1374 2889-5571 141 µM -0.00701328308499845 0.495100480220835 no 1698 0.497202127789078 2431 2853281 SGTC_1111 tnp00062 510.699 nM -0.00728849928049771 0.495004331579097 no 1699 0.497092335219959 2422 676306 SGTC_2005 4024620 188 µM -0.00731853661821207 0.49499383784921 no 1700 0.497080352375549 2429 236743 SGTC_1645 Cervolide 78 µM -0.0076388966270635 0.494881918313767 no 1701 0.496952550797713 2424 23173 A fragrance. SGTC_2954 9074818 52.69 µM -0.00845894641091905 0.494595431256619 no 1702 0.496625408873204 2429 16648742 SGTC_1658 st012944 20 µM -0.00945402494181965 0.494247801095259 no 1703 0.496228445913518 2435 24207260 SGTC_2798 7813637 45.45 µM -0.00969890170766876 0.494162254185493 no 1704 0.496130758697861 2439 956368 SGTC_3007 9078383 71.4286 µM -0.0100965407472004 0.494023340840908 no 1705 0.49597213144384 2428 6496995 SGTC_2167 5876490 200 µM -0.0120746713258987 0.493332301247918 no 1706 0.495183020137187 2450 686534 SGTC_235 0330-0087 5 mM -0.0123121060272708 0.493249357178671 no 1707 0.495088304437564 2432 46494818 YHR062C RPP1 SGTC_3239 9133757 49.47 µM -0.0128251599081411 0.493070130896248 no 1708 0.494883641720583 2425 17036923 SGTC_826 1683-5028 118 µM -0.0129597095673545 0.493023128586971 no 1709 0.494829968633568 2447 722377 SGTC_2345 9052315 157.45 µM -0.0130235296568699 0.49300083431249 no 1710 0.494804510250077 2442 6469265 SGTC_888 0916-0002 6.97 µM -0.0131650245242531 0.492951405982749 no 1711 0.494748066804172 2480 2802138 YIL048W NEO1 SGTC_2886 9058944 51.95 µM -0.0155821951798132 0.492107034336747 no 1712 0.493783855073967 2428 4949929 SGTC_3088 9117578 49.47 µM -0.0157740211075543 0.492040026724803 no 1713 0.493707337005798 2430 678341 SGTC_2458 5808907 16.39 µM -0.0160026670116032 0.491960157648327 no 1714 0.493616132000229 2436 2731747 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.0166752570635163 0.491725214816063 no 1715 0.493347843210003 2431 442882 SGTC_2405 ticlatone 3.52 µM -0.0167677162677922 0.491692918058864 no 1716 0.493310962480655 2427 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1210 3013-0140 750 nM -0.0175004788608604 0.491436960027898 no 1717 0.493018675414894 2446 905973 SGTC_3338 9144300 39.5675 µM -0.0201058085822185 0.490526933212352 no 1718 0.491979483252214 2452 4901274 SGTC_3277 9138724 49.47 µM -0.0206820717669613 0.49032565426119 no 1719 0.491749635309682 2464 15943418 SGTC_1036 k216-0215 33.5 µM -0.02084454703269 0.490268904851098 no 1720 0.49168483102729 2441 622330 SGTC_856 0433-0016 11.3 µM -0.0211568396354589 0.490159827750265 no 1721 0.491560271774852 2466 3911780 SGTC_316 k060-0003 58.6 µM -0.0212872473963595 0.490114279336745 no 1722 0.491508258319475 2460 6152314 SGTC_2814 7977482 42.97 µM -0.0216481342960825 0.489988230566691 no 1723 0.491364318449526 2460 6456762 SGTC_2968 9090663 33.37 µM -0.0236892673504648 0.489275333017255 no 1724 0.490550233509277 2514 25236811 SGTC_865 0488-0499 301 µM -0.0243260023533373 0.489052950292215 no 1725 0.490296286193421 2438 9634651 SGTC_1486 3970-0793 4.53 µM -0.0253116797411679 0.488708704518011 no 1726 0.489903178915237 2452 2844330 SGTC_1621 st003705 32.4 µM -0.0265533166403402 0.488275077421078 no 1727 0.489408004020232 2441 24207032 SGTC_493 zm226600 134 µM -0.0270562003043533 0.488099455125263 no 1728 0.489207454526501 2493 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1348 1493-0373 93.8 µM -0.0271429147910902 0.488069172017051 no 1729 0.4891728731518 2472 3010129 SGTC_2180 6301957 200 µM -0.0276265104670312 0.487900288236238 no 1730 0.488980018718423 2457 845462 SGTC_2197 6588183 93.1375 µM -0.0289333913414042 0.487443903484514 no 1731 0.488458857161877 2456 884136 SGTC_2360 9040895 200 µM -0.0290340452336678 0.487408754129086 no 1732 0.488418718931303 2470 4914414 SGTC_1116 jasmonic acid  1.58368 µM -0.0291586434975209 0.487365243292849 no 1733 0.48836903245249 2471 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_512 prima-1 270 µM -0.0312030287175878 0.486651347413945 no 1734 0.487553812262295 2496 322968 A re-activator of the apoptotic function of mutant p53. SGTC_501 nsc-95397 161 µM -0.0313548058708616 0.486598348764971 no 1735 0.4874932915518 2470 262093 SGTC_2270 7924575 90.91 µM -0.0315689004165539 0.486523590078847 no 1736 0.487407922447367 2480 1262135 SGTC_1385 3091-4834 14.1 µM -0.0325566692524117 0.486178681812682 no 1737 0.487014062212051 2488 4072814 SGTC_2306 7482397 179.52 µM -0.0343576551089247 0.485549841924395 no 1738 0.486295974923854 2473 891448 SGTC_2439 5492030 7.2 µM -0.0348958341339367 0.485361935947269 no 1739 0.486081401235661 2490 5722370 SGTC_2863 9028737 58.44 µM -0.0374278928323851 0.484477908338621 no 1740 0.485071916491407 2482 6460917 SGTC_3344 9148862 3.898 µM -0.0374347600990878 0.484475510844568 no 1741 0.485069178766959 2508 4905352 SGTC_2621 lithochol-11-enic acid 100 µM -0.0378976421854401 0.48431391115997 no 1742 0.484884646481876 2465 6708711 SGTC_1503 4585-0012 61.3 µM -0.0401063028821502 0.483542867629101 no 1743 0.484004188436526 2534 2922052 SGTC_2895 9054447 58.44 µM -0.0417238687726624 0.482978214192623 no 1744 0.483359412998937 2472 2697450 SGTC_777 1315-0167 517 µM -0.0451066438621272 0.481797480262516 no 1745 0.48201115288913 2545 4221767 SGTC_1575 cyproterone acetate 48 µM -0.0474797979657186 0.48096924213081 no 1746 0.481065415531161 2503 9880 An androgen receptor antagonist and liver toxin. SGTC_1386 3228-0095 33.8 µM -0.0486823803090209 0.480549568303551 no 1747 0.48058620885073 2528 870181 SGTC_1686 st019653 115.5 µM -0.0494380816046938 0.480285856776435 no 1748 0.480285090259941 2485 97252 SGTC_2733 amorolfine 100 µM -0.0529532496153841 0.479059309681147 no 1749 0.478884578409122 2529 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_468 gf-109203x 121 µM -0.0537187884346073 0.478792216216735 no 1750 0.478579606704146 2497 2396 A protein kinase C inhibitor. SGTC_573 3702-0553 84.7 µM -0.0545863339595815 0.478489544534561 no 1751 0.47823401322298 2506 1222756 SGTC_552 k242-0005 476 µM -0.0549957395018536 0.478346714294359 no 1752 0.478070929021379 2565 4088318 SGTC_1351 1496-0003 46.5 µM -0.0554221389977704 0.47819795829174 no 1753 0.477901079286037 2527 3891978 SGTC_1502 4534-4282 27.7 µM -0.0554476924987669 0.478189043657334 no 1754 0.477890900565854 2522 3278949 SGTC_392 N-ethylmaleimide 8.33 µM -0.0564798539155193 0.477828971379188 no 1755 0.477479772074783 2530 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_11 0438-0307 1.3 µM -0.0569481137058151 0.477665623645526 no 1756 0.477293263639198 2540 4011476 SGTC_1729 st035615 45.989 µM -0.0577092063330825 0.477400132129938 no 1757 0.476990130163189 2640 17385451 SGTC_585 0kpi-0023 191 µM -0.0579500436954788 0.477316123050992 no 1758 0.476894210481475 2529 64601 SGTC_1304 1165-0502 251 µM -0.0592549708081974 0.476860954968433 no 1759 0.476374513073202 2537 767425 SGTC_901 1112-0062 60.1 µM -0.0601681060886864 0.476542464648033 no 1760 0.476010873665196 2492 1908457 SGTC_919 tnp00227 403.569 nM -0.060309989197868 0.476492978909861 no 1761 0.475954373100182 2552 1269246 A methoxyflavone. YNL221C POP1 SGTC_2853 9015042 58.44 µM -0.0616146725279458 0.476037950872604 no 1762 0.47543484607817 2520 6457456 SGTC_1832 st054113 55 µM -0.0632711474125611 0.475460275308181 no 1763 0.474775295372437 2514 1251267 SGTC_292 k038-0015 474 µM -0.0639616267876427 0.475219494145941 no 1764 0.474500390800167 2584 46368540 SGTC_457 grayanotoxin iii 135 µM -0.0646631914878084 0.474974856623522 no 1765 0.47422108519822 2574 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_521 r062-0005 13.8 µM -0.0646758402541551 0.474970446050542 no 1766 0.474216049611327 2500 2832033 SGTC_1236 0330-0013 258 µM -0.0679781930256999 0.473819035714431 no 1767 0.47290149678294 2554 4617066 SGTC_345 1362-0200 395 µM -0.0679930599322002 0.473813852651945 no 1768 0.472895579436294 2553 1419823 SGTC_1260 0700-1617 7.75 µM -0.0686833081394056 0.473573215716918 no 1769 0.472620852499614 2576 2853078 SGTC_333 3486-0131 40.1 µM -0.0686995591885587 0.473567550330673 no 1770 0.472614384546581 2650 6744690 SGTC_1887 st057648 70.8 µM -0.0687413135321292 0.473552994095992 no 1771 0.472597766259822 2567 688672 SGTC_456 gingerol 170 µM -0.0705807649798806 0.472911767102858 no 1772 0.471865709774858 2635 442793 A herb. SGTC_577 r071-0003 38.6 µM -0.0707801981613198 0.472842249510584 no 1773 0.471786345934771 2538 4568517 YMR134W ERG29 SGTC_3125 9127534 49.47 µM -0.0721419669603588 0.472367592000543 no 1774 0.471244464204395 2530 1639235 SGTC_2725 haloperidol 53.21 µM -0.0723511313716506 0.472294689208521 no 1775 0.471161237165424 2531 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_672 1441-0018 53.7 µM -0.0729427946458898 0.472088474148334 no 1776 0.470925819710717 2543 251141 SGTC_1415 3966-0071 78.1 µM -0.0730937904272388 0.47203584810617 no 1777 0.470865741481777 2559 2893185 SGTC_2195 6536160 144.242 µM -0.0738513294676741 0.471771833007936 no 1778 0.470564341746143 2542 3834386 SGTC_408 cantharidin 100 µM -0.07443082388908 0.471569877821649 no 1779 0.470333791450861 2588 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2446 5162541 200 µM -0.075120879955661 0.471329401178177 no 1780 0.470059267479842 2531 1549321 SGTC_518 1021-0119 62.6 µM -0.0756332599158262 0.471150849382277 no 1781 0.469855437326766 2587 1097762 SGTC_2922 7999257 32.47 µM -0.0763237871427301 0.470910226832004 no 1782 0.469580750817308 2545 2988377 SGTC_2565 isoliquiritigenin 100 µM -0.0766556239403631 0.470794598065508 no 1783 0.46944875379034 2663 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2560 caryophyllene 100 µM -0.0769937607006482 0.470676776605382 no 1784 0.469314254237388 2539 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1102 cgs 12066b 26.1 µM -0.0776019319476169 0.470464869927362 no 1785 0.469072352772958 2626 6438352 A 5-HT1B full agonist. SGTC_2487 5918373 44.05 µM -0.0781321765888569 0.470280122240298 no 1786 0.468861456101801 2530 2876279 SGTC_764 1951-2361 146 µM -0.079722860398664 0.46972593517839 no 1787 0.468228838675717 2564 5438930 SGTC_2533 agelasine 13.65 µM -0.079960585044915 0.469643117994853 no 1788 0.468134302065472 2594 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1514 1189-1591 158 µM -0.0799944943994767 0.469631304950381 no 1789 0.468120817386022 2670 767698 YMR146C TIF34 SGTC_1397 3532-0190 20.1 µM -0.0806384035947917 0.46940699057958 no 1790 0.46786476199334 2531 5322280 SGTC_2024 5144227 134 µM -0.081446156163834 0.469125612919016 no 1791 0.467543571848458 2613 3475211 SGTC_711 k292-0785 179 µM -0.0815864368649239 0.469076748216106 no 1792 0.467487793574625 2551 4146315 SGTC_713 1488-1073 324 µM -0.0843984573370224 0.468097321800882 no 1793 0.466369816889265 2542 3312542 SGTC_732 3970-1727 52.7 µM -0.0856389442010362 0.467665321387659 no 1794 0.465876719584552 2615 1275699 SGTC_499 genistein 192 µM -0.0888293153662983 0.466554448532754 no 1795 0.464608779742142 2548 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2772 vinpocetine 57.06 µM -0.0925098167862726 0.465273238667872 no 1796 0.463146496000488 2649 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_775 4577-0580 57.3 µM -0.0936326104073423 0.464882456905084 no 1797 0.462700502021223 2770 2006902 SGTC_2444 5485484 36.41 µM -0.0940311170422529 0.464743767122046 no 1798 0.462542219206631 2659 6790631 SGTC_1603 st002045 67.8 µM -0.0940396795520673 0.464740787212009 no 1799 0.462538818329125 2587 5887985 SGTC_2995 9067767 71.4286 µM -0.0941706118683696 0.464695220617394 no 1800 0.462486814669313 2641 11673567 SGTC_2812 7970281 58.44 µM -0.0959679682107555 0.464069758172593 no 1801 0.461773006387035 2672 2233435 SGTC_1696 st025591 34.7925 µM -0.0964367208024653 0.463906651385628 no 1802 0.46158686451824 2596 2787147 SGTC_3107 9121808 49.47 µM -0.0969885002299729 0.463714662420512 no 1803 0.461367763439897 2570 662681 SGTC_2050 5263056 171 µM -0.0970966163980331 0.463677044914906 no 1804 0.461324833944998 2618 763468 YGL055W OLE1 SGTC_1270 0831-1170 17.3 µM -0.0983804978542772 0.463230361271753 no 1805 0.460815080003223 2582 6764716 SGTC_698 k064-0052 127 µM -0.101117900027112 0.462278129159504 no 1806 0.459728434354468 2555 5088751 SGTC_2834 9001755 58.44 µM -0.103963858090924 0.461288364073259 no 1807 0.458599015083243 2734 2989575 SGTC_2838 9002687 71.43 µM -0.104022324645213 0.46126803311257 no 1808 0.458575816086026 2580 6457060 SGTC_730 1436-0052 41.2 µM -0.104501759603641 0.461101319854364 no 1809 0.458385585982393 2584 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_559 1550-0661 158 µM -0.104919088911311 0.460956208072601 no 1810 0.458220005903209 2664 5830875 SGTC_346 4513-0042 7.16 µM -0.106294791785051 0.460477892066533 no 1811 0.457674231867382 2614 2827372 SGTC_1861 st057647 17.4 µM -0.106446602018911 0.460425112891572 no 1812 0.457614010008986 2790 688668 SGTC_1752 st044819 83.042 µM -0.107278733681749 0.460135821863084 no 1813 0.457283927615579 2632 441209 YML126C ERG13 SGTC_2351 9026858 72.31 µM -0.107347903650608 0.460111775833314 no 1814 0.45725649122694 2592 1409300 SGTC_1958 st076513 41.9 µM -0.107527801287159 0.460049237469778 no 1815 0.457185135470278 2598 732122 YGL099W LSG1 SGTC_1975 st070967 30.8 µM -0.109429514415861 0.459388199886184 no 1816 0.45643091259576 2627 261391 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.109768585072673 0.459270350291341 no 1817 0.456296452966599 2571 4000243 SGTC_1677 st019204 53.9 µM -0.110607959894499 0.458978627156722 no 1818 0.455963617569387 2728 3945625 SGTC_1687 st020778 55.3625 µM -0.110776931580415 0.458919904032141 no 1819 0.455896619338205 2620 4259299 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.11150147495521 0.458668111959746 no 1820 0.455609348024679 2606 688664 SGTC_1627 st003713 25.6 µM -0.11301525146811 0.458142100570323 no 1821 0.455009231879433 2687 16195070 YER133W GLC7 SGTC_2755 lomerizine 42.69 µM -0.113791842431725 0.45787227691157 no 1822 0.454701402692528 2652 3949 A calcium channel blocker. SGTC_1855 st056195 39.6 µM -0.114063062450256 0.45777804708681 no 1823 0.454593901482934 2676 4028379 SGTC_1180 1193-0155 285 µM -0.11603409920834 0.457093322471558 no 1824 0.453812758526791 2708 2921347 SGTC_683 panaxydol 45 µM -0.116301270328621 0.457000518818344 no 1825 0.453706889434617 2678 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_270 tamoxifen 5.46 µM -0.116847587659688 0.456810759190627 no 1826 0.453490416255641 2659 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_959 1222-0044 107 µM -0.117453327803233 0.456600370965924 no 1827 0.453250413495247 2633 6083612 SGTC_923 1900-2434 73.3 µM -0.11763730962612 0.45653647202818 no 1828 0.453177520687244 2603 5910570 SGTC_2969 9091408 28.7 µM -0.120422305978323 0.455569349970053 no 1829 0.452074311181253 2658 4286311 SGTC_1547 harmine 94.2 µM -0.120535818373452 0.455529937027783 no 1830 0.452029353757494 2633 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_302 1094-0063 18.9 µM -0.120593840079077 0.455509791325214 no 1831 0.452006374069315 2621 5440289 SGTC_263 alizarin 107.927 µM -0.120917604291793 0.45539737933178 no 1832 0.451878149137361 2601 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1261 0712-0010 12.7 µM -0.121409669476063 0.455226539531452 no 1833 0.451683279201688 2686 2840123 SGTC_1642 st009582 77.7 µM -0.121883336115731 0.455062095331022 no 1834 0.45149570653909 2685 6739311 SGTC_2512 diallyl trisulfide 49.23 µM -0.122072501387006 0.454996424433465 no 1835 0.45142079984628 2596 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2034 5197015 53.07 µM -0.12289268172745 0.454711703653329 no 1836 0.4510960404172 2757 780676 SGTC_366 0181-0206 4.31 µM -0.124542810322878 0.454138941858452 no 1837 0.450442753239152 2670 274874 SGTC_1857 st056007 79.3 µM -0.124670835671665 0.454094508063223 no 1838 0.450392073494466 2697 619834 SGTC_424 splitomicin 100 mM -0.125911013929725 0.453664108854394 no 1839 0.449901182105022 2724 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1513 0337-0559 19 µM -0.126218532018895 0.453557394255658 no 1840 0.449779471125785 2648 775073 SGTC_2713 st079149 53.4 µM -0.126823230381733 0.453347562262996 no 1841 0.449540154505804 2693 3103253 SGTC_2511 berberine 10.47 µM -0.126837597228013 0.453342577086044 no 1842 0.449534468877161 2664 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1768 st044301 37.178 µM -0.127428885465545 0.453137411340571 no 1843 0.4493004776481 2675 3931349 SGTC_2027 5150920 200 µM -0.127986508312749 0.452943938303185 no 1844 0.44907982501723 2716 786715 SGTC_930 2810-3379 265 µM -0.128108770617589 0.452901519618374 no 1845 0.449031447647173 2802 1015764 SGTC_1906 st060206 94.7 µM -0.128493372107302 0.452768086336221 no 1846 0.448879271519483 2657 5133468 SGTC_1136 pergolide 1.05886 µM -0.128828281049982 0.452651897683716 no 1847 0.448746763477204 2653 47811 A dopamine receptor agonist. SGTC_2697 mebhydrolin 72.4 µM -0.12912835013067 0.452547799331682 no 1848 0.448628044818988 2714 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1700 st030840 7.9285 µM -0.132660852451326 0.451322569735727 no 1849 0.447230802181368 2751 5499307 SGTC_833 3852-0053 558 µM -0.133073835030502 0.451179358973477 no 1850 0.447067493852003 2781 3123681 SGTC_153 4077-0274 519.67 µM -0.133590308227331 0.451000269515544 no 1851 0.446863274202351 2671 3121976 SGTC_1702 st027038 51 µM -0.133924813126204 0.450884283722111 no 1852 0.446731014498313 2710 5521182 SGTC_2245 6637752 200 µM -0.134473857212507 0.450693917985392 no 1853 0.446513941115745 2797 681890 SGTC_514 4466-0038 2.65 nM -0.134731421821381 0.450604618540409 no 1854 0.446412114336629 2708 5722064 SGTC_2322 7413319 38.22 µM -0.135375094436798 0.45038146370072 no 1855 0.446157657303218 2752 1840400 SGTC_1515 3460-0031 42.1 µM -0.135848053042129 0.450217503689351 no 1856 0.4459707011569 2676 2876596 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.136846592898142 0.449871368974335 no 1857 0.445576027121362 2632 88881 An O-methylated flavonoid and antioxidant. SGTC_1483 3453-0561 55.9 µM -0.137769567920784 0.449551462026069 no 1858 0.44521126812536 2744 4546991 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.13941846551777 0.448980029059979 no 1859 0.444559740742925 2648 15053 SGTC_2117 5521686 200 µM -0.139527690901832 0.448942180229865 no 1860 0.444516587887591 2662 803312 SGTC_1125 tnp00248 1.32998 µM -0.140748861803085 0.448519051245066 no 1861 0.444034171570232 2810 24207736 SGTC_2449 5812982 45.77 µM -0.140991325324424 0.448435045923679 no 1862 0.443938397637756 2661 776185 SGTC_114 0364-0001 490.298 µM -0.14104408467941 0.448416766916942 no 1863 0.443917557942944 2698 4003655 SGTC_2944 9067346 25.62 µM -0.141930070002755 0.44810982482249 no 1864 0.44356762115804 2789 6473075 SGTC_1910 st062352 60.4 µM -0.142705904228998 0.447841069145468 no 1865 0.44326122677399 2627 2245730 SGTC_1546 5-methoxyflavanone 78.7 µM -0.143315357291476 0.447629966125416 no 1866 0.44302056383348 2731 147795 SGTC_101 0490-5701 117.494 µM -0.144291883349848 0.447291746908202 no 1867 0.442634993693196 2639 4661669 SGTC_2928 9011484 9.79 µM -0.144593454381651 0.447187305695494 no 1868 0.442515932784028 2750 2994751 SGTC_1192 1488-0095 21.4 µM -0.145890668154454 0.446738091596151 no 1869 0.442003849251251 2737 915875 SGTC_3172 9105863 49.47 µM -0.146227807651729 0.446621354219356 no 1870 0.441870777083613 2699 2348785 SGTC_1430 4049-0248 69.1 µM -0.14973196756699 0.445408285219303 no 1871 0.440488043008851 2775 22774488 SGTC_3056 9094900 49.47 µM -0.150098120844865 0.445281559679546 no 1872 0.440343601269432 2721 25236784 SGTC_2844 9010103 25.97 µM -0.150593922346859 0.445109971841925 no 1873 0.440148027989479 2852 2480525 SGTC_987 1497-1013 404 µM -0.152080111914485 0.44459569053551 no 1874 0.439561875066237 2675 1676435 SGTC_749 1000-0129 128 µM -0.152270593226814 0.444529783071805 no 1875 0.439486758818147 2822 708470 SGTC_1399 3562-5772 25 µM -0.153303501443371 0.444172418540806 no 1876 0.439079469781851 2663 23847490 SGTC_3215 9129942 49.47 µM -0.15393056075078 0.443955491321959 no 1877 0.438832243637975 2729 17682944 SGTC_222 nsc-310342 10.666 µM -0.155161686834854 0.443529639908319 no 1878 0.438346925952547 2679 432556 SGTC_102 gallobenzophenone 83.616 µM -0.156065499087523 0.443217049131228 no 1879 0.437990696414758 2831 70837 SGTC_2300 7976697 71.57 µM -0.156068295551634 0.443216082006234 no 1880 0.437989594291195 2715 2236109 SGTC_1670 st016595 4.04 µM -0.156178579136601 0.44317794196481 no 1881 0.43794613045259 2683 597879 SGTC_1801 st050089 28.441 µM -0.157922320823859 0.442574963394043 no 1882 0.437259004646234 2677 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2732 terfenadine 20 µM -0.157932988288849 0.442571275037218 no 1883 0.437254801684931 2676 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_58 0957-0393 9 µM -0.158127517002639 0.442504016134205 no 1884 0.43717815897703 2689 6997992 SGTC_2572 astragaloside iv 100 µM -0.158390610305132 0.442413053449654 no 1885 0.437074506137905 2865 45006101 An anti-inflammatory agent. SGTC_942 3253-1115 227 µM -0.160628159565082 0.441639559495708 no 1886 0.436193137378864 2848 46497897 SGTC_2657 nystatin 74.44 µM -0.161148054149196 0.441459869919005 no 1887 0.435988396528979 2737 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_23 0213-0011 39.996 µM -0.161358048660858 0.441387293571578 no 1888 0.435905702980558 2807 627608 SGTC_2861 9024595 19.48 µM -0.163231485518377 0.440739901152301 no 1889 0.435168088397202 2755 16482810 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.163494898327015 0.440648887814592 no 1890 0.435064394826536 2761 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1263 0774-1208 64.8 µM -0.164557511372455 0.440281769896635 no 1891 0.434646138103508 2795 906585 SGTC_1325 1431-0015 227 µM -0.164700424221889 0.440232399418765 no 1892 0.434589891530361 2694 1103340 SGTC_1534 6-azauridine 81.6 µM -0.164976946018768 0.440136875215359 no 1893 0.434481063904442 2671 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1588 farnesol 29.9 µM -0.166515505064145 0.43960544517004 no 1894 0.433875641116027 2697 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_701 4424-0219 185 µM -0.16659079042131 0.439579443817409 no 1895 0.43384602030626 2805 2911779 SGTC_571 k831-0106 44.2 µM -0.166662866875311 0.439554550969957 no 1896 0.433817662378402 2731 4783639 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.168374282441864 0.438963554489362 no 1897 0.433144419444928 2767 6857784 SGTC_2017 5132927 60.65 µM -0.170240471682534 0.438319265713254 no 1898 0.432410512220569 2724 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_874 0599-0792 117 µM -0.170419468001507 0.438257477050048 no 1899 0.432340131416436 2753 765305 SGTC_378 3970-0959 8.33 µM -0.170759960275028 0.43813994492054 no 1900 0.43220625682585 2833 6615653 SGTC_556 4058-0063 51.5 µM -0.17150193470414 0.437883846907417 no 1901 0.4319145546534 2711 6615692 SGTC_1243 0416-0003 5.65 µM -0.172100496451362 0.43767726780567 no 1902 0.431679261237619 2778 2141977 SGTC_2136 5328288 199.296 µM -0.172572590890363 0.437514347813691 no 1903 0.431493698958194 2756 262395 SGTC_329 k048-0121 21.3 µM -0.17344403054905 0.437213641461571 no 1904 0.431151209073878 2796 6832902 SGTC_71 0417-1750 47.813 µM -0.174558040735974 0.436829284504885 no 1905 0.430713460461463 2910 6811472 SGTC_1733 st037357 54.9 µM -0.174664794109138 0.43679245546963 no 1906 0.430671516346207 2699 1272339 YGL099W LSG1 SGTC_2988 9073640 71.4286 µM -0.175061669891709 0.436655541397281 no 1907 0.430515588055446 2891 9102229 SGTC_360 0957-0399 1.01 µM -0.175404340317128 0.436537333174098 no 1908 0.430380965189242 2853 6752301 YPR165W RHO1 SGTC_2283 7944793 200 µM -0.175768947894753 0.436411563693474 no 1909 0.430237732891491 2774 2970533 SGTC_2092 5303694 80.6725 µM -0.176329706340331 0.43621814554538 no 1910 0.430017462684609 2749 1963699 SGTC_815 1582-0027 36.9 µM -0.177196512302758 0.43591919477776 no 1911 0.429677017548095 2812 3128206 SGTC_631 k072-0230 41.5 µM -0.177352250659695 0.435865486399295 no 1912 0.429615855567602 2829 5773147 SGTC_1071 trifluoperazine 6.31 µM -0.178510428961254 0.435466110862248 no 1913 0.429161065805059 2853 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2419 paclitaxel 166.5 µM -0.179515682263167 0.435119521909414 no 1914 0.428766402338074 2663 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_337 1315-0038 354 µM -0.179619043303359 0.435083888145827 no 1915 0.428725826719794 2738 1626437 SGTC_2805 7950783 58.44 µM -0.180655920109344 0.43472645363461 no 1916 0.428318830022768 2853 1178958 YDL195W SEC31 SGTC_3132 9126706 49.47 µM -0.181046530491439 0.434591815359525 no 1917 0.428165526697674 2937 850858 SGTC_3197 9113331 49.47 µM -0.181534707055171 0.434423557967128 no 1918 0.427973946699906 2916 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_486 niguldipine 82 µM -0.181877663946729 0.434305359819678 no 1919 0.427839366856819 2711 1236 A calcium channel blocker. SGTC_2453 5731132 22.18 µM -0.18565444332227 0.433004104946218 no 1920 0.426357878038145 2855 1362040 SGTC_2519 cryptotanshinone 88.04 µM -0.187106233377808 0.432504096354816 no 1921 0.425788670470223 2843 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2902 5787006 60.46 µM -0.188248897557454 0.432110629250729 no 1922 0.425340771454999 2747 591003 SGTC_851 0394-0702 453 µM -0.188281606413002 0.432099367212085 no 1923 0.425327951724654 2766 762646 SGTC_2785 7756463 72.73 µM -0.189224863041736 0.431774616780044 no 1924 0.424958290888724 2764 2201551 SGTC_20 0481-0013 4.944 µM -0.189596854654186 0.431646557789228 no 1925 0.424812526064303 2745 182045 SGTC_705 1124-0212 310 µM -0.189616982319822 0.431639628997543 no 1926 0.424804639336328 2793 9554485 SGTC_529 4076-0302 30.3 µM -0.189673476535802 0.431620181417317 no 1927 0.42478250307449 2759 5816522 SGTC_2835 9006588 71.43 µM -0.189914686112723 0.431537149249302 no 1928 0.424687992026541 2974 2345538 SGTC_1825 st052143 62.6 µM -0.190327122597297 0.431395182230305 no 1929 0.424526400663528 2887 674173 SGTC_3140 9094243 49.47 µM -0.190893906051978 0.431200101056901 no 1930 0.424304357323882 2694 19291112 SGTC_479 n-linoleoylglycine 10 µM -0.191291994615491 0.431063093001414 no 1931 0.424148416327947 2751 6433346 An anti-infammatory. SGTC_2849 9019321 12.99 µM -0.191495556891942 0.430993037243457 no 1932 0.424068680608328 2865 16489627 SGTC_2959 9079155 11 µM -0.191509089785479 0.430988379988352 no 1933 0.424063379859086 2919 16189457 SGTC_1509 1326-1131 80 µM -0.193216154768789 0.4304009821184 no 1934 0.423394843722413 2744 768313 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.19341318215831 0.430333195248776 no 1935 0.423317696240695 2940 94937 An inhibitor of serotonin biosynthesis. SGTC_331 k048-0133 24.5 µM -0.195900499551664 0.42947761600543 no 1936 0.422344023129456 2747 6813582 SGTC_977 1348-1378 135 µM -0.195945621014763 0.429462098319239 no 1937 0.422326364464815 2737 X977 SGTC_135 0933-0004 26.348 µM -0.196145935152578 0.429393209761035 no 1938 0.422247971725286 2859 21230617 YGL099W LSG1 SGTC_269 exalamide 29 µM -0.196376134523085 0.429314046248176 no 1939 0.422157887233324 2783 3316 A derivative of salicylamide. SGTC_1921 5740136 50 µM -0.196932230276459 0.429122821606501 no 1940 0.421940285709375 2898 1774243 SGTC_1909 st060837 51.5 µM -0.197021503976496 0.429092124608357 no 1941 0.421905354927052 2817 678937 SGTC_2584 androsterone 48.74 µM -0.198238961390925 0.428673541530929 no 1942 0.421429052773376 2869 2754130 A steroid. SGTC_1096 rimcazole 32.2 µM -0.198321878301078 0.428645036164565 no 1943 0.421396617616348 2732 18528119 A dopamine reuptake inhibitor. SGTC_1043 0916-0009 19.3 µM -0.198513775781601 0.428579066634521 no 1944 0.421321553853617 2919 3101130 SGTC_2375 9072683 200 µM -0.198963277827107 0.428424546945348 no 1945 0.421145735151552 2796 16798029 SGTC_1094 duloxetine 25.4 µM -0.199149765433869 0.42836044365514 no 1946 0.421072796806117 2749 60834 A selective serotonin reuptake inhibitor. SGTC_350 k064-0020 19.8 µM -0.199399546644353 0.428274586769621 no 1947 0.420975107543968 2945 2790705 SGTC_881 0833-0569 170 µM -0.203187300791412 0.426973046645114 no 1948 0.419494319153621 2789 5418700 SGTC_2927 9011802 47.9 µM -0.203920690313886 0.426721132262117 no 1949 0.419207738130308 2884 43912568 SGTC_914 3820-6779 408 µM -0.204929517395754 0.426374655777303 no 1950 0.418813596526784 2744 2893481 SGTC_2897 9048598 12.99 µM -0.205801770459009 0.426075130726105 no 1951 0.418472879089355 2787 6467404 SGTC_2801 7907800 81.82 µM -0.206513672091945 0.425830700728806 no 1952 0.418194843064965 2864 6620925 SGTC_2848 9016370 25.97 µM -0.207550194191847 0.425474863919484 no 1953 0.417790098337191 2814 7894410 SGTC_3190 9110366 49.47 µM -0.208835843153723 0.425033586510059 no 1954 0.41728819470529 2853 17123768 SGTC_1088 bifonazole 369 nM -0.209744367466217 0.424721807400122 no 1955 0.41693359771413 2758 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_714 4296-0578 26.1 µM -0.210334469756501 0.424519326676074 no 1956 0.416703316998035 2797 1589775 SGTC_1426 4048-4480 71.7 µM -0.211158814621188 0.424236504080998 no 1957 0.416381673644625 2883 14224343 SGTC_2731 amoxapine 43.43 µM -0.211299078785207 0.4241883850492 no 1958 0.416326950859893 2776 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1163 k060-0048 49.9 µM -0.211471664930468 0.424129179187546 no 1959 0.416259620174473 2784 6809982 SGTC_2645 abamectin 100 µM -0.211502757400356 0.424118513064492 no 1960 0.416247490392961 2889 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1439 4092-1168 46 µM -0.211905134634031 0.423980484496014 no 1961 0.416090522352481 2806 2886240 SGTC_369 0957-0393 4.5 µM -0.212271331908012 0.423854874943137 no 1962 0.415947679807403 2853 6997992 SGTC_508 roscovitine 141 µM -0.214508970899098 0.423087509529099 no 1963 0.415075086006539 2782 160355 A CDKinase inhibitor. SGTC_2708 st078559 56 µM -0.215319445877815 0.42280964085088 no 1964 0.414759134781197 2829 17250902 SGTC_3265 9137266 49.47 µM -0.21793688284483 0.421912524145062 no 1965 0.41373914470703 2760 17224265 SGTC_2779 methotrexate 400 µM -0.21800560667877 0.421888974745809 no 1966 0.413712371495932 2834 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_3287 9117173 37.0625 µM -0.220885305304037 0.420902448732478 no 1967 0.412590869753659 2847 2789709 SGTC_3179 9107801 49.47 µM -0.222266689753496 0.420429390413335 no 1968 0.412053140638815 2816 4818259 SGTC_37 0566-0070 1.56 µM -0.223274495520669 0.420084337437541 no 1969 0.411660937939251 2910 1626686 SGTC_2190 6049624 200 µM -0.22487324118314 0.419537084297471 no 1970 0.411038943311144 2807 2265554 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.227036610350233 0.418796807546671 no 1971 0.410197637221807 2810 16623 A steroid. SGTC_414 piperonyl butoxide 100 µM -0.227337805158172 0.418693765342804 no 1972 0.410080539161343 2803 5794 A potent inhibitor of cytochrome P450. SGTC_670 4204-0025 119 µM -0.227631847071561 0.418593175607387 no 1973 0.409966229726718 2916 719039 SGTC_2198 6589944 200 µM -0.228192580516866 0.418401367274839 no 1974 0.409748264592259 2843 5290268 SGTC_190 3970-0790 3.722 µM -0.229684936670086 0.417890976330844 no 1975 0.409168300401166 2848 2832352 SGTC_1053 3366-3204 134 µM -0.229871849520908 0.417827061217623 no 1976 0.409095675715986 2859 3632071 YPR165W RHO1 SGTC_160 3453-0671 289.699 µM -0.230114195797671 0.417744193797854 no 1977 0.409001517109035 2840 5322268 SGTC_2486 5283202 22.39 µM -0.232033644231721 0.417087990603989 no 1978 0.408255941243961 2880 1377751 SGTC_259 usnic acid 108.925 µM -0.233018972244342 0.416751225391014 no 1979 0.40787333675872 3015 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_352 k048-0007 5.11 µM -0.234098171796597 0.416382446879379 no 1980 0.407454382599959 2891 6811911 SGTC_861 0443-0273 110 µM -0.234683440153451 0.416182482747789 no 1981 0.407227220831501 2917 6149169 SGTC_2889 9059656 51.95 µM -0.235509432399295 0.415900309263696 no 1982 0.406906679361796 2915 3949838 SGTC_2606 farnesol 9.78 µM -0.237376600782325 0.415262611665565 no 1983 0.406182320447034 3001 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3204 9114183 49.47 µM -0.238409148864894 0.414910059254507 no 1984 0.405781886107128 2777 17027248 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.238700700824156 0.414810524373579 no 1985 0.405668836641124 2884 77254 SGTC_669 0108-0021 26.2 µM -0.238770834578562 0.414786581756025 no 1986 0.40564164340476 2860 17201 SGTC_3100 9120536 49.47 µM -0.240037808174981 0.414354110464652 no 1987 0.405150473291887 2769 16421196 SGTC_2658 polymyxin b sulfate 77.05 µM -0.240182784503892 0.414304630565153 no 1988 0.405094279545921 2855 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2544 sphondin 68.51 µM -0.240805196430719 0.414092219076071 no 1989 0.404853050975939 3052 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1190 1486-1332 13 µM -0.240985456950896 0.414030705976949 no 1990 0.40478319404372 2829 4150046 SGTC_933 2914-0560 114 µM -0.241392891492564 0.413891678528583 no 1991 0.404625310825077 3037 463887 SGTC_1003 4049-0218 100 µM -0.241404470265286 0.413887727702517 no 1992 0.404620824211111 2989 295161 SGTC_97 0535-0701 19.132 µM -0.241839560741536 0.413739275560738 no 1993 0.404452241775711 2849 2832013 YGL099W LSG1 SGTC_3281 9140613 49.47 µM -0.244508626306491 0.41282886539303 no 1994 0.403418460932528 2863 16013766 SGTC_169 k015-0017 16.025 µM -0.245202666945938 0.412592206819606 no 1995 0.40314975574508 3037 1840002 SGTC_343 4130-2827 29.8 µM -0.245534095924679 0.412479205174894 no 1996 0.403021455627797 2890 1118244 SGTC_3157 9099274 49.47 µM -0.246135720334324 0.412274098178069 no 1997 0.402788586317089 2937 17217662 SGTC_1673 st016611 27.3 µM -0.248598444987931 0.411434751498716 no 1998 0.401835705732057 3051 5226799 SGTC_1705 st027868 56.3335 µM -0.249854553944942 0.411006799792563 no 1999 0.40134991469157 2923 292948 SGTC_2377 9073351 62.6 µM -0.250451804204539 0.4108033559376 no 2000 0.401118985907892 2828 7337946 YHR072W ERG7 SGTC_2822 7994718 71.43 µM -0.250806762969059 0.410682456211907 no 2001 0.400981756289508 2773 1018011 SGTC_2646 retinol 96.75 µM -0.250845325051053 0.410669322393883 no 2002 0.400966848645882 2925 445354 A vitamin A analog and teratogen. SGTC_1072 oxiconazole 14.9 nM -0.252043686074196 0.41026122389504 no 2003 0.400503648459236 2850 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3115 9123671 49.47 µM -0.252504799079026 0.410104219011102 no 2004 0.400325452568575 2820 3286988 SGTC_3311 9131146 2.8755 µM -0.253789921053889 0.409666722507026 no 2005 0.39982893020529 2891 4900406 YPR165W RHO1 SGTC_2700 st077718 96.8 µM -0.254963731307317 0.409267218310695 no 2006 0.39937555593342 2902 904970 SGTC_869 0564-0080 44.1 µM -0.256520958249688 0.408737364405308 no 2007 0.398774299683467 2900 6843321 SGTC_47 0149-0135 24.25 µM -0.256568546344264 0.40872117494978 no 2008 0.398755929360546 2839 5239155 SGTC_2188 6126565 140.678 µM -0.256630833855442 0.408699984992472 no 2009 0.398731884994497 2971 874518 SGTC_2218 6965428 192.983 µM -0.256980339399737 0.408581089583468 no 2010 0.398596975204554 2890 675684 SGTC_3104 9120930 49.47 µM -0.257181406507649 0.408512694033769 no 2011 0.398519368416355 2943 17014836 SGTC_460 trequinsin 123 µM -0.257421627312876 0.408430983506369 no 2012 0.398426654558631 2930 5537 A vasodilator. SGTC_1024 4507-0395 26 µM -0.258053828609945 0.408215960793427 no 2013 0.39818268220002 3028 4201836 SGTC_3218 9131285 49.47 µM -0.259210695614703 0.407822561697323 no 2014 0.397736339579968 3024 17156417 SGTC_2702 st077768 96.8 µM -0.260025503438738 0.407545537484597 no 2015 0.397422050578674 2950 6484119 SGTC_50 0929-0078 56.389 µM -0.263110313569917 0.406497161509537 no 2016 0.396232777429262 2885 1377751 SGTC_1836 st055642 81 µM -0.263433338052785 0.406387419915365 no 2017 0.396108298861535 2884 8571 SGTC_223 busulfan 5 mM -0.264426579745719 0.406050030517668 no 2018 0.395725616252689 2964 2478 A DNA alkylator. SGTC_2864 9034755 47.6 µM -0.266301944591307 0.40541318742919 no 2019 0.395003337796058 2845 4930451 SGTC_2743 auranofin 4.32 µM -0.266384624241135 0.405385116527682 no 2020 0.394971502818978 2909 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1756 st041558 35.5 µM -0.268921883908997 0.404523918550128 no 2021 0.393994898091607 3075 3955792 SGTC_621 3584-0052 32.1 µM -0.269101649802801 0.404462919809233 no 2022 0.393925730445285 2972 2273927 SGTC_3250 9135583 49.47 µM -0.269560587838732 0.404307202014809 no 2023 0.393749162274976 3015 7699353 SGTC_2072 5231554 129 µM -0.269954742044327 0.404173477489943 no 2024 0.393597535953995 2980 789545 SGTC_1322 1348-1070 12 µM -0.270144680686852 0.404109041086504 no 2025 0.393524474631111 2914 6758089 SGTC_1281 0884-0031 11.8 µM -0.270147485449373 0.404108089594457 no 2026 0.39352339578626 2883 1548255 SGTC_429 1112-0049 25.5 µM -0.270924527308925 0.40384450656121 no 2027 0.39322454010057 2869 2836170 SGTC_3046 9092212 49.47 µM -0.271453281369791 0.40366517103754 no 2028 0.393021213581424 2883 25236637 SGTC_1659 st012954 42.1 µM -0.272222931650712 0.403404167852086 no 2029 0.392725305255418 3018 24207262 SGTC_2396 5342950 42.78 µM -0.273867498823088 0.402846607861561 no 2030 0.392093224584913 2985 1886677 SGTC_1200 1643-0193 18.4 µM -0.274062142582961 0.402780630555552 no 2031 0.39201843309411 2936 5403974 SGTC_3258 9138477 49.47 µM -0.275352625900569 0.402343272754703 no 2032 0.391522668393039 2921 4970355 SGTC_990 3985-0011 41.3 µM -0.276652177794129 0.401902965028696 no 2033 0.391023597814533 2938 5399565 YGL099W LSG1 SGTC_617 3770-0098 35 µM -0.276748872480918 0.401870208383327 no 2034 0.390986471042342 2902 5962639 SGTC_1403 3909-7815 62.9 µM -0.276818381792647 0.401846661580797 no 2035 0.390959782946863 2876 6615483 SGTC_3034 9090421 49.47 µM -0.277792099973168 0.401516844710445 no 2036 0.390585977954211 2880 17173761 SGTC_2373 9071805 200 µM -0.28017264807443 0.400710803610531 no 2037 0.389672525157627 3038 10149009 SGTC_3035 9091303 49.47 µM -0.280216632098627 0.400695914816159 no 2038 0.389655653529028 2906 25237002 SGTC_2467 5474540 200 µM -0.281370422576113 0.40030540302622 no 2039 0.389213150733583 2890 5413519 SGTC_509 pifithrin 175 µM -0.28150086910303 0.400261258372806 no 2040 0.389163130787771 2981 4817 A p53 inhibitor. SGTC_755 1995-0008 37.3 µM -0.281830840866531 0.400149597700081 no 2041 0.389036610746917 2989 689533 SGTC_29 0299-0004 12.984 µM -0.282542017502246 0.399908967110331 no 2042 0.388763966535935 2936 16871 A napthoquinone isolated from Swertia calycina. SGTC_3168 9103419 49.47 µM -0.283163599615908 0.399698682447166 no 2043 0.388525715087904 2964 16649256 SGTC_3329 9141233 27.5565 µM -0.2831899626821 0.399689764318835 no 2044 0.388515611092352 3061 4909101 YNL103W MET4 SGTC_94 0334-0113 514.748 µM -0.286106530962352 0.398703468385156 no 2045 0.387398264782718 2936 6795178 SGTC_2885 9057732 51.95 µM -0.28645211243369 0.398586645816796 no 2046 0.387265933041655 3069 6471414 SGTC_2691 st077356 60.2 µM -0.286607356016024 0.39853416924162 no 2047 0.387206490675687 3083 2839272 SGTC_2340 7987427 183.45 µM -0.286646022553097 0.39852109918029 no 2048 0.387191685770046 3044 2239331 SGTC_684 1140-0066 328 µM -0.286808733808879 0.398466100775499 no 2049 0.387129387580562 2969 6813534 SGTC_1219 1469-0211 33.1 µM -0.288674948567863 0.397835441711646 no 2050 0.386415067527527 3022 6822282 SGTC_2515 chrysin 20.77 µM -0.289149722914405 0.39767504141736 no 2051 0.386233402238875 2993 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_616 4092-0450 108 µM -0.289325117671414 0.397615789492388 no 2052 0.386166296369593 2972 787165 SGTC_952 1185-0122 232 µM -0.290136197091402 0.397341821064047 no 2053 0.385856022458176 2867 678600 SGTC_210 3551-0445 56.827 µM -0.291626493986423 0.396838556960386 no 2054 0.385286108134046 3041 2865180 YOR207C RET1 SGTC_1979 st071809 45.3 µM -0.293062425720882 0.396353814104292 no 2055 0.384737218189327 3050 4976333 SGTC_1074 carmofur 3.8 µM -0.293716087350498 0.396133203555656 no 2056 0.384487430165309 2927 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1671 st016596 74.5 µM -0.294203768463737 0.395968633026793 no 2057 0.384301100597841 2962 2829167 SGTC_3001 9076041 71.4286 µM -0.294558586883459 0.395848909355423 no 2058 0.384165551016412 2909 16004211 SGTC_2389 9091542 195.52 µM -0.297558048657952 0.394837217518973 no 2059 0.383020248595617 2984 3626624 YOL127W RPL25 SGTC_1312 1218-2183 165 µM -0.298610622479012 0.394482361343098 no 2060 0.382618579746371 2928 6744073 SGTC_1410 3909-8106 77.9 µM -0.299563172012917 0.39416130199346 no 2061 0.382255189594339 3017 1039210 SGTC_503 tyrphostin 8 294 µM -0.301102032701006 0.393642776911294 no 2062 0.381668345521998 3049 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1798 st045719 60.953 µM -0.301128351064654 0.39363391047377 no 2063 0.381658311382581 2946 3980186 SGTC_2247 cerulenin 830 nM -0.302275704794653 0.393247430226561 no 2064 0.381220948683658 3160 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1257 0669-0121 16 µM -0.302653515343356 0.393120189672596 no 2065 0.381076963281967 3019 4307855 SGTC_2842 9000675 19.48 µM -0.303723784694443 0.392759802086544 no 2066 0.380669167966612 2994 2989072 SGTC_401 neomycin 50 µM -0.307380973972019 0.391529026567011 no 2067 0.379276704121164 2997 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2594 a-mangostin 100 µM -0.308250305641745 0.391236624400542 no 2068 0.378945938204443 3118 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_61 0978-8327 98.565 µM -0.30934944118898 0.390867015043365 no 2069 0.378527862710378 3058 6150059 YHR072W ERG7 SGTC_1640 st009078 66.4 µM -0.310283230673538 0.390553084488117 no 2070 0.378172791140479 3079 690618 SGTC_3226 9131256 49.47 µM -0.312190484622574 0.389912106895613 no 2071 0.377447881580194 2951 17178073 SGTC_746 1095-0025 46.6 µM -0.313042059641355 0.389626011590783 no 2072 0.377124353933697 3142 6749286 SGTC_2734 clemastine 41.6 µM -0.314580772716031 0.389109216998764 no 2073 0.376539989828915 2984 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3136 9095672 49.47 µM -0.315391173252097 0.388837113384963 no 2074 0.376232333921428 2875 17217380 SGTC_847 0342-0274 5.54 µM -0.316259570913474 0.388545596921716 no 2075 0.3759027475822 3088 18097 SGTC_3079 9117512 49.47 µM -0.318467928257063 0.387804546234597 no 2076 0.375065009379846 2993 7185044 SGTC_2791 5663188 71.43 µM -0.319751471941566 0.387374019518739 no 2077 0.374578368742365 3142 54690634 SGTC_1516 st013856 110 µM -0.320001905829022 0.387290035016615 no 2078 0.374483442909523 3071 5281404 A mutagen and neurotoxin. SGTC_1113 artemisinin 1.17947 µM -0.322633673519145 0.386407775684957 no 2079 0.373486344299377 3074 2240 An anti-malaria and mitochondrial poison. SGTC_2867 9039098 71.43 µM -0.324310082382137 0.385846091292561 no 2080 0.372851643607121 2946 6463460 SGTC_92 0063-0024 660.874 µM -0.324636513536604 0.385736747624752 no 2081 0.372728094455028 2950 3594437 SGTC_956 1185-0240 191 µM -0.324812983848044 0.385677639672315 no 2082 0.372661308617867 2991 1416193 SGTC_1109 tnp00067 928.257 nM -0.325046528831007 0.385599418891899 no 2083 0.37257292854744 2997 676295 SGTC_1009 4106-0057 9.87 µM -0.326298035401482 0.385180333497023 no 2084 0.372099437241248 3147 2928005 SGTC_2709 st078560 56 µM -0.326995825192337 0.38494672649677 no 2085 0.371835521408146 3147 17250903 SGTC_1359 1582-0056 520 nM -0.327044496158352 0.384930433922484 no 2086 0.371817115475374 3085 3661189 SGTC_3071 9117417 49.47 µM -0.328632462918082 0.384398974687678 no 2087 0.37121675393075 3028 45595590 YGL055W OLE1 SGTC_2317 5986382 200 µM -0.328990242972875 0.384279263141973 no 2088 0.371081531449038 3055 877883 SGTC_2185 6113692 200 µM -0.330263605982372 0.383853291408131 no 2089 0.370600394873585 3119 874150 SGTC_2324 6149169 200 µM -0.330414947307564 0.383802673272834 no 2090 0.370543224423115 3045 2888231 SGTC_38 0929-0051 58.268 µM -0.331852621538894 0.383321922834683 no 2091 0.370000273699042 3118 1379719 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.33186399684691 0.383318119708828 no 2092 0.369995978742054 2996 5106787 A p450 inhibitor. SGTC_653 0203-0016 55.2 µM -0.333022464368971 0.382930866256843 no 2093 0.3695586629916 3029 295302 SGTC_1056 3448-1962 115 µM -0.333266794082072 0.382849206450291 no 2094 0.369466451257632 3066 715507 SGTC_1433 4060-0023 7.6 µM -0.33489618362655 0.382304765657442 no 2095 0.368851700533524 3107 3840627 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.33693196274641 0.381624861653603 no 2096 0.368084094928743 2965 2333 A French combination drug. SGTC_907 3448-6986 75.5 µM -0.337481558039911 0.381441371798079 no 2097 0.367876956059677 3181 590582 SGTC_2022 5136654 200 µM -0.337547558409852 0.381419338469032 no 2098 0.367852083534809 3141 1713771 SGTC_2216 7189485 200 µM -0.338314998404314 0.381163167258963 no 2099 0.367562911159724 3109 731273 SGTC_1185 1319-0113 81.3 µM -0.341954592837391 0.379948982619874 no 2100 0.366192532089628 3111 4672763 SGTC_1865 st057639 52.2 µM -0.342824795974985 0.379658853742485 no 2101 0.365865135331374 2980 688818 SGTC_2071 5230951 39.92 µM -0.342834089076629 0.37965575575401 no 2102 0.365861639511896 3078 1799272 SGTC_2204 7233102 200 µM -0.344137346822522 0.379221372718043 no 2103 0.365371498782701 3016 2172480 SGTC_1504 k297-0033 30 µM -0.344747158105306 0.379018171556107 no 2104 0.365142230981624 2962 4388117 SGTC_680 0417-1641 114 µM -0.347056537085038 0.378248944321941 no 2105 0.364274422406724 2984 2835990 SGTC_1381 2324-0066 62.1 µM -0.347598806263209 0.378068390586587 no 2106 0.364070751453519 3136 10885928 SGTC_2865 9030313 51.95 µM -0.34811290063403 0.37789724251144 no 2107 0.363877698125996 2981 42562754 SGTC_1973 st070275 50.2 µM -0.348644264424259 0.377720370427801 no 2108 0.363678196072648 3066 17118334 SGTC_229 benomyl 22.8748 µM -0.34924561357492 0.377520233633601 no 2109 0.363452462395722 3102 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1519 esterone 74 µM -0.349501892195984 0.377434950775722 no 2110 0.363356275255524 2999 698 A steroid. SGTC_808 0711-0032 135 µM -0.351071135556269 0.376912877883372 no 2111 0.362767490955954 3131 4252555 SGTC_3177 9107506 49.47 µM -0.351800830996439 0.376670191462093 no 2112 0.362493817654641 3122 8897194 SGTC_68 0986-0284 82.829 µM -0.353794271088626 0.376007450040867 no 2113 0.361746533594621 3184 423278 YIL048W NEO1 SGTC_658 3253-0951 102 µM -0.354154350678556 0.375887776479982 no 2114 0.36161160608805 3073 1184878 SGTC_1317 1273-0028 910 nM -0.355360386698633 0.375487033695342 no 2115 0.361159810760226 3032 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2735 sertaconazole 140 nM -0.355628702946328 0.375397895569392 no 2116 0.361059322632141 3069 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3018 9082602 49.47 µM -0.35644997569195 0.375125099506685 no 2117 0.360751804299922 3085 17332089 SGTC_1440 4100-1550 40 µM -0.357704947421929 0.374708365541199 no 2118 0.360282065132294 3069 742806 SGTC_46 0329-0187a 2.197 µM -0.357838163266019 0.374664137612695 no 2119 0.360232214462929 3118 46494817 SGTC_1782 st039423 80.636 µM -0.357845833452388 0.374661591145566 no 2120 0.360229344276652 3060 2068169 SGTC_1101 ebselen 5.29 µM -0.359476433328203 0.374120363629746 no 2121 0.359619352354914 3187 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_553 k007-0256 45.7 µM -0.360031861844384 0.373936062781895 no 2122 0.359411653368814 3089 6287000 SGTC_2143 5623677 140.463 µM -0.361581871944592 0.373421894989019 no 2123 0.358832256716031 3104 5375313 SGTC_1248 0469-0687 58.6 µM -0.361686734201458 0.373387118312068 no 2124 0.358793070720293 3143 4017482 SGTC_821 1114-0266 29.2 µM -0.362229746375473 0.373207049438258 no 2125 0.358590176185325 3111 3123235 SGTC_1406 3909-7906 11.9 µM -0.362632236773764 0.373073597013569 no 2126 0.358439812851535 3082 X1406 SGTC_1526 st051518 75 µM -0.362651293972195 0.373067278658073 no 2127 0.358432693961336 3079 673993 SGTC_2046 4110841 106 µM -0.363485250112054 0.37279081652326 no 2128 0.358121214635152 3205 44119630 YMR134W ERG29 SGTC_827 3253-0474 693 µM -0.363629817871112 0.372742897986025 no 2129 0.358067228743634 3173 5402065 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.364126464855885 0.372578294013442 no 2130 0.357881787647881 3212 1273210 SGTC_1495 4469-0029 237 µM -0.364921830593422 0.37231473400971 no 2131 0.357584878980913 3058 793680 SGTC_2630 antimycin a 100 µM -0.36684573937686 0.371677456644274 no 2132 0.356867043734136 2999 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3043 9092303 49.47 µM -0.36739229959685 0.371496477556037 no 2133 0.356663207323714 3105 25236084 SGTC_332 4112-0506 40.9 µM -0.367656360611047 0.371409050847412 no 2134 0.356564741985642 3055 2790355 SGTC_284 0988-0104 32.6 µM -0.367934158835594 0.371317083111489 no 2135 0.356461164516519 3125 4666532 SGTC_971 1315-0384 26.7 µM -0.371528178268398 0.370127913023916 no 2136 0.355122086099286 3075 6769120 SGTC_1458 k015-0034 6.33 µM -0.371537588184761 0.370124801143935 no 2137 0.3551185824426 3100 3598957 SGTC_2980 9014342 25.29 µM -0.373903934608845 0.369342515583079 no 2138 0.354237894518209 3210 2996599 SGTC_3045 9092950 49.47 µM -0.374006570342211 0.369308597660202 no 2139 0.354199713963327 3215 44120432 SGTC_2479 5617353 43.85 µM -0.375817196493173 0.368710409435432 no 2140 0.353526401239267 3225 2731746 SGTC_3279 9140807 49.47 µM -0.380026876109975 0.367320861647685 no 2141 0.351962732454297 3104 45595718 SGTC_3173 9105693 49.47 µM -0.38015683029332 0.367277993380587 no 2142 0.351914501138748 3241 17096658 SGTC_2234 tolnaftate 200 µM -0.382148273147156 0.3666212790288 no 2143 0.351175693639472 3111 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_192 3455-0609 60.9 µM -0.385123581026397 0.365640844957415 no 2144 0.350072928914998 3208 3769639 SGTC_2244 6635614 200 µM -0.385974967679228 0.365360454105436 no 2145 0.34975760396445 2977 836499 SGTC_524 r073-0010 27.8 µM -0.386173811639382 0.365294978321776 no 2146 0.349683973773443 3039 2772106 SGTC_1500 4488-1866 171 µM -0.386346723799923 0.365238044610459 no 2147 0.349619950498288 3204 2900003 SGTC_2220 6782180 200 µM -0.386637257982235 0.36514238891603 no 2148 0.349512385567686 3136 833803 SGTC_1081 sertraline 6 µM -0.386752591898243 0.365104418616267 no 2149 0.349469688658966 3189 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1794 st048918 76.9 µM -0.388014572231738 0.364689035189614 no 2150 0.349002624866015 3150 672303 SGTC_1709 st033179 39.1045 µM -0.38870480920906 0.364461909414823 no 2151 0.348747262185995 3074 573381 SGTC_940 3232-1287 54.8 µM -0.390524054442605 0.363863506218491 no 2152 0.348074535836315 3182 1585493 YIL048W NEO1 SGTC_1904 st060225 78 µM -0.392209913416694 0.363309273885351 no 2153 0.347451559958738 3159 66595 SGTC_1425 4048-4433 7.33 µM -0.392669072661593 0.363158373110419 no 2154 0.347281958017345 3179 23734946 SGTC_1607 st000305 50.6 µM -0.393885793690701 0.362758605571426 no 2155 0.346832679642881 3227 5457690 SGTC_1816 st051957 91.6 µM -0.394541540921725 0.362543214343296 no 2156 0.346590631985028 3120 674121 SGTC_2320 7373003 200 µM -0.394935294223657 0.362413900332334 no 2157 0.34644532090438 3167 5415828 SGTC_253 dyclonine 31.25 µM -0.395113544870782 0.362355365523568 no 2158 0.346379546550126 3141 3180 An oral anasthetic. SGTC_1341 1486-1360 280 µM -0.395546743701326 0.362213123014214 no 2159 0.34621971582068 3092 3976547 SGTC_187 1488-2104 32.728 µM -0.397472505696447 0.361581022133683 no 2160 0.345509528756971 3176 2852859 SGTC_1554 st069299 38.7 µM -0.397684775919015 0.361511370865916 no 2161 0.345431280451398 3181 24207999 SGTC_2659 sanguinarine 24.21 µM -0.398284029461679 0.361314765283023 no 2162 0.345210415718247 3080 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1833 st055984 71 µM -0.399090359969688 0.361050278829096 no 2163 0.344913312557102 3123 676288 SGTC_836 0330-0104 1.35 µM -0.399712025018176 0.360846410283672 no 2164 0.344684317083503 3142 46494820 SGTC_2170 morpholine 200 µM -0.399956156918858 0.360766360589842 no 2165 0.344594404628894 3208 121171 Reacts with secondary amines. SGTC_2836 9010338 19.48 µM -0.40041432690609 0.360616145289608 no 2166 0.344425686809456 3096 2994051 SGTC_307 1501-1223 22.3 µM -0.401037240939499 0.360411951616781 no 2167 0.344196352822942 3193 2830329 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.40260504914625 0.359898194196367 no 2168 0.343619397322691 3024 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2998 9066762 71.4286 µM -0.402759655537995 0.359847544686698 no 2169 0.343562521666958 3298 4945196 SGTC_1283 0922-0125 16.4 µM -0.403926583887903 0.35946533496452 no 2170 0.343133353509842 3195 3360884 SGTC_1078 idebenone 36.1 µM -0.407554314914569 0.358278025759422 no 2171 0.341800455210263 3183 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_291 SEC14.278 35.5 µM -0.407562055833276 0.358275493717114 no 2172 0.341797613147805 3233 1068044 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.407723606266633 0.358222652247401 no 2173 0.341738302283299 3242 61125 An anti-inflammatory. SGTC_1295 1013-0063 9.78 µM -0.409065945085629 0.357783692257542 no 2174 0.341245633545539 3252 6826038 SGTC_3235 9132602 49.47 µM -0.409596176433066 0.357610352371785 no 2175 0.341051101109718 3239 4912240 SGTC_607 4491-0986 66.8 µM -0.410202915888228 0.357412036967286 no 2176 0.340828551041876 3246 698981 YDR232W HEM1 SGTC_181 1447-1644 8.07 µM -0.410258898412602 0.357393740777338 no 2177 0.340808019622909 3219 534600 SGTC_523 1934-0222 13.7 µM -0.411742142072919 0.35690910709303 no 2178 0.340264216482161 3119 1361595 SGTC_2312 7706453 155.7 µM -0.412152123466286 0.356775190832467 no 2179 0.340113963109897 3135 976098 SGTC_2228 7354201 200 µM -0.413050453766328 0.356481822085028 no 2180 0.339784824376051 3167 753451 SGTC_2082 5219693 150 µM -0.414440391482181 0.356028075896829 no 2181 0.339275806579808 3126 2834649 SGTC_624 k048-0052 28 µM -0.419444116084812 0.354396298068479 no 2182 0.337445794186591 3170 6835531 SGTC_1688 st021091 57.6 µM -0.419734777678096 0.354301591395105 no 2183 0.337339608057113 3256 3656366 SGTC_2952 9073731 13.78 µM -0.422054093351041 0.353546208735511 no 2184 0.336492767297301 3153 16457353 SGTC_3041 9091929 49.47 µM -0.42208612488658 0.353535780347827 no 2185 0.336481077566099 3318 25236887 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.422308935029021 0.35346324392223 no 2186 0.336399768614392 3267 1377 SGTC_909 3448-9333 149 µM -0.422367891766001 0.353444051292309 no 2187 0.336378255117462 3123 3344074 SGTC_271 rotenone 740 µM -0.422383970416877 0.353438817152853 no 2188 0.336372388060653 3270 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_602 3130-1533 38.1 µM -0.422667375685176 0.353346563795189 no 2189 0.33626898077623 3253 720941 SGTC_1320 1313-0481 95.3 µM -0.424710592016154 0.352681716514331 no 2190 0.33552383071345 3313 6813365 YLR208W SEC13 SGTC_313 3474-0040 5.03 µM -0.424847438856519 0.352637203624379 no 2191 0.335473946469166 3112 1043375 YIL048W NEO1 SGTC_2177 5811945 192 µM -0.424904669299531 0.352618588576125 no 2192 0.33545308533928 3284 5343475 SGTC_1058 3448-5425 97.3 µM -0.427975317976648 0.351620333144799 no 2193 0.334334545135091 3204 7279705 SGTC_3325 9138760 55.175 µM -0.428086773972272 0.351584118439077 no 2194 0.33429397281621 3155 43844959 SGTC_1323 1348-1351 11.2 µM -0.42892956623306 0.351310318796299 no 2195 0.333987241456144 3161 6989654 SGTC_900 1112-0045 141 µM -0.429590086916404 0.351095788009 no 2196 0.333746924695111 3196 56211 YIL048W NEO1 SGTC_2404 5161160 200 µM -0.429864546925004 0.351006659978486 no 2197 0.333647088155672 3150 2831543 SGTC_1884 5633444 25 µM -0.433783465719249 0.349734928059624 no 2198 0.332222844709237 3289 5724239 SGTC_986 1493-0483 84 µM -0.43495421462152 0.34935533333779 no 2199 0.331797830676647 3271 40079 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.436069704634945 0.348993795452887 no 2200 0.331393078426225 3277 688662 SGTC_620 0109-0052 432 µM -0.436325300854753 0.348910974268323 no 2201 0.331300363797546 3316 493037 SGTC_3159 9100096 49.47 µM -0.441246483482142 0.347317764473458 no 2202 0.329517282390025 3131 25236875 SGTC_1276 0871-0068 94.2 µM -0.442361619074753 0.346957117957388 no 2203 0.329113773992399 3226 3414906 SGTC_2839 9003951 25.97 µM -0.442945852430396 0.346768226083093 no 2204 0.328902450357077 3284 2990634 SGTC_1144 3486-0183 12.5 µM -0.443641903987053 0.346543231332706 no 2205 0.328650752232121 3219 6744069 SGTC_1667 st014849 34.6 µM -0.444333081536534 0.346319865634175 no 2206 0.328400893486562 3228 5348460 SGTC_2260 7964312 200 µM -0.444336120012133 0.346318883817391 no 2207 0.328399795255467 3323 231951 SGTC_3294 9122953 26.2835 µM -0.444808138245067 0.346166374017525 no 2208 0.328229206301591 3184 16459826 SGTC_1020 4335-0961 93.3 µM -0.445543107541336 0.34592895400096 no 2209 0.327963657268503 3124 669075 SGTC_2268 7933382 153.85 µM -0.44599316404438 0.34578360037296 no 2210 0.327801091933619 3275 935025 YOR257W CDC31 SGTC_2799 7812892 81.82 µM -0.446345833191987 0.345669715578059 no 2211 0.327673726776921 3313 20205235 SGTC_882 0843-0131 351 µM -0.447024382019603 0.345450636199815 no 2212 0.327428727784123 3319 5425421 SGTC_3209 9113616 49.47 µM -0.447024460773287 0.345450610776043 no 2213 0.327428699353378 3383 16649353 SGTC_2521 angolensin 13.4 µM -0.447273848750208 0.345370105239742 no 2214 0.327338673210418 3311 821428 A flavenoid. SGTC_3293 9120939 62.045 µM -0.451886408904441 0.343882378077716 no 2215 0.325675408000629 3299 934087 SGTC_965 1291-5240 308 µM -0.452242466858968 0.343767635837235 no 2216 0.325547158980229 3317 2834598 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.453456433106345 0.343376534693542 no 2217 0.325110054053056 3365 16725076 SGTC_1678 st019265 80.2 µM -0.454556199903275 0.343022369683895 no 2218 0.324714275837516 3392 5367020 SGTC_1572 epiandrosterone 68.9 µM -0.454776044015172 0.342951588388571 no 2219 0.3246351832202 3221 441302 A steroid. SGTC_2938 9059746 27.26 µM -0.456528996142605 0.342387402998552 no 2220 0.324004812348493 3276 6471769 SGTC_387 norethindrone acetate 66.7 µM -0.456584259986677 0.34236962211095 no 2221 0.323984947368744 3226 541197 SGTC_1863 st057641 20.1 µM -0.45707691075996 0.342211129435243 no 2222 0.323807882718884 3282 3921635 SGTC_2424 5537928 59.2 µM -0.457589943801294 0.342046109036725 no 2223 0.323623534810739 3198 5382802 SGTC_2295 7971645 200 µM -0.458154815366282 0.341864449333917 no 2224 0.32342060984476 3215 2978226 YKL099C UTP11 SGTC_231 b-estradiol 524 µM -0.460539647890301 0.341097903785517 no 2225 0.322564459908026 3195 450 A steroid. SGTC_903 1134-0042 114 µM -0.46069588374944 0.341047708465264 no 2226 0.322508404317522 3220 701009 SGTC_2094 5332512 191.667 µM -0.461225103598374 0.340877702082691 no 2227 0.322318556439742 3335 755774 SGTC_720 r052-1644 49.9 µM -0.462165683384619 0.340575630347248 no 2228 0.321981255138929 3299 1422863 YOR257W CDC31 SGTC_3269 9137823 49.47 µM -0.46262722634144 0.340427440977542 no 2229 0.321815794828558 3184 17682936 SGTC_1026 k007-1105 30.6 µM -0.463087191321253 0.340279782763102 no 2230 0.321650935357949 3288 7066794 SGTC_9 0092-0002 10.449 µM -0.465728070739846 0.339432480666903 no 2231 0.320705078477188 3290 759368 SGTC_2634 4'-methoxyflavone 100 µM -0.46592524490088 0.339369251620959 no 2232 0.320634505195093 3271 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2337 9009472 200 µM -0.466224787670746 0.339273204059897 no 2233 0.320527304180288 3407 5742383 SGTC_1578 josamycin 24.2 µM -0.466514107446457 0.339180444387112 no 2234 0.320423776005068 3211 5282165 A P450 substrate. SGTC_285 1486-1325 46 µM -0.467319702415992 0.338922211557621 no 2235 0.320135581146209 3336 22310230 SGTC_998 3996-0085 177 µM -0.469799670057417 0.338127735387919 no 2236 0.319249075080081 3234 715391 SGTC_2001 4023502 57.655 µM -0.471223249385897 0.337672006282943 no 2237 0.318740658822306 3299 108941 YCR052W RSC6 SGTC_2917 7979103 53.79 µM -0.471303353525856 0.337646369684847 no 2238 0.31871206060298 3342 2980565 SGTC_2239 6685329 187.64 µM -0.471775460754968 0.337495291387458 no 2239 0.318543534122195 3333 805680 SGTC_1353 1498-1206 8.11 µM -0.471969060819132 0.337433345303912 no 2240 0.318474436227929 3332 6756808 SGTC_3227 9130768 49.47 µM -0.473506540120417 0.336941555616258 no 2241 0.317925918053841 3288 17720899 SGTC_3295 9122362 53.5725 µM -0.473892038360346 0.336818290904929 no 2242 0.31778844848419 3310 4730473 SGTC_2403 6032726 181.2 µM -0.473905074806816 0.33681412275169 no 2243 0.317783800095899 3253 2881040 SGTC_1331 1472-0049 76.2 µM -0.47465824833906 0.336573344031844 no 2244 0.317515290794084 3208 24051409 SGTC_220 paclitaxel 373.376 µM -0.475891584511739 0.336179208934364 no 2245 0.317075808949609 3313 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_949 1165-0505 146 µM -0.476276991351084 0.336056082035406 no 2246 0.316938527548854 3209 6244267 SGTC_1992 st073643 23.3 µM -0.477258879564977 0.335742475233427 no 2247 0.316588894186134 3240 3161292 SGTC_664 1222-0054 14.9 µM -0.477776209356841 0.335577290451306 no 2248 0.316404747891362 3278 6813991 SGTC_931 2812-0076 566 µM -0.477840223256107 0.335556852850886 no 2249 0.316381964966253 3227 3450959 SGTC_1251 0490-5699 265 µM -0.478985002201602 0.335191443568961 no 2250 0.315974649108667 3419 3883818 SGTC_500 h-89 112 µM -0.479414905436578 0.335054260265385 no 2251 0.315821745867385 3381 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2808 7946468 45.46 µM -0.479649841432951 0.334979300839156 no 2252 0.315738199737115 3276 2970879 SGTC_2676 harmalol 100 µM -0.480032140271596 0.334857337407441 no 2253 0.31560226969234 3345 5459187 A monoamine oxidase inhibitor SGTC_2045 5106652 78.05 µM -0.480542682963423 0.334694487959326 no 2254 0.315420780206795 3329 673349 SGTC_1736 st036774 51 µM -0.480700502858758 0.334644153927535 no 2255 0.315364686850011 3441 1272247 SGTC_2499 avocadenofuran 51.48 µM -0.481714457508475 0.334320840854127 no 2256 0.315004402142391 3200 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2461 5755302 26.15 µM -0.481834004239346 0.334282729864139 no 2257 0.314961935638994 3363 2788904 SGTC_2763 lisinopril 49.32 µM -0.483196615410441 0.333848455990992 no 2258 0.314478069153613 3362 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_510 ag-490 170 µM -0.485353338125818 0.333161547962119 no 2259 0.313712863000323 3391 5328779 SGTC_2495 cafestol 54.53 µM -0.485566306971899 0.333093748494773 no 2260 0.31363734494748 3387 16667697 An anti-infammatory. SGTC_2721 ifenprodil 61.44 µM -0.488528361766314 0.33215133312804 no 2261 0.312587820819716 3380 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1201 1889-3372 45.9 µM -0.488857785439737 0.332046588228117 no 2262 0.312471192084441 3230 5392199 SGTC_3103 9120822 49.47 µM -0.49077205464349 0.331438179259081 no 2263 0.311793838624047 3465 17141819 SGTC_2963 9082507 9 µM -0.491355996592368 0.331252674381802 no 2264 0.311587340548563 3369 16459611 SGTC_955 1216-0110 33 µM -0.492356696914526 0.330934871278344 no 2265 0.311233602926302 3302 3619719 SGTC_3154 9100113 49.47 µM -0.493283830563929 0.330640540207637 no 2266 0.310906025886715 3247 25237525 SGTC_1164 k060-0068 93.7 µM -0.493708720431592 0.330505688167078 no 2267 0.310755952836862 3311 5963676 SGTC_534 k292-0788 63.4 µM -0.496000949966833 0.329778557614605 no 2268 0.309946870355476 3421 4146317 SGTC_64 000l-0018 272.079 µM -0.49613182778001 0.329737060528827 no 2269 0.309900702457882 3306 6811119 SGTC_2236 dapsone 200 µM -0.496799967670537 0.329525247830861 no 2270 0.309665059014947 3352 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1226 3909-7979 35.4 µM -0.498016648086377 0.329139678127931 no 2271 0.309236154050394 3368 6615510 SGTC_1804 st050076 49.1 µM -0.498843833270888 0.32887764436076 no 2272 0.30894470252854 3360 3895976 SGTC_1107 amlodipine 47 µM -0.499253026503746 0.328748052173548 no 2273 0.308800571286102 3331 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1917 st066507 28.5 µM -0.499476545775476 0.328677271937213 no 2274 0.308721852919132 3229 3156428 SGTC_2361 9034121 116 µM -0.499884352711643 0.328548150491031 no 2275 0.30857825530344 3283 6496917 SGTC_2048 5246248 200 µM -0.500679100412807 0.328296573159194 no 2276 0.308298491622165 3383 677046 SGTC_1511 0906-3109 28.5 µM -0.501091908184637 0.328165929597661 no 2277 0.308153220710087 3355 2882180 SGTC_2931 9014674 55.67 µM -0.503518672294891 0.327398343475967 no 2278 0.307299827863844 3229 2996810 SGTC_2006 4011487 200 µM -0.503786304446744 0.327313735940374 no 2279 0.307205776409419 3426 45595294 SGTC_818 4072-2707 53.5 µM -0.504033047055657 0.327235740151802 no 2280 0.307119077204925 3255 882871 SGTC_2682 pyrogallin 40.03 µM -0.504290893916365 0.327154242348737 no 2281 0.30702848776365 3319 822798 An ATP competetive kinase inhibitor. SGTC_2091 4-phenylthiadiazole 200 µM -0.504677450955497 0.327032078484934 no 2282 0.306892700590351 3258 270010 SGTC_2106 5357045 167.29 µM -0.504764769115387 0.327004485837448 no 2283 0.306862031717537 3332 668842 SGTC_2719 novobiocin 32.65 µM -0.504992083827983 0.326932658540481 no 2284 0.30678219801053 3398 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_314 1671-0008 2.74 µM -0.507140503989095 0.326254113984945 no 2285 0.306028118496255 3300 3913060 SGTC_3309 9129340 25.759 µM -0.507473244906686 0.326149074366722 no 2286 0.305911402279249 3313 17158987 SGTC_249 wiskostatin 11.211 µM -0.507825812721754 0.326037790843552 no 2287 0.305787752843852 3391 2775510 A n-wasp and actin depolymerizer. SGTC_1306 1185-0270 9.02 µM -0.509559172971781 0.325490903307082 no 2288 0.305180166379946 3374 1548076 SGTC_1450 4112-4260 37.6 µM -0.509699721549806 0.325446575669423 no 2289 0.305130924052897 3407 1633175 SGTC_1392 3455-1037 33.9 µM -0.510349227769102 0.325241759879802 no 2290 0.304903410142075 3429 981132 SGTC_1761 st044296 37 µM -0.512149308531446 0.324674397032782 no 2291 0.304273258639453 3296 1826700 SGTC_297 0986-0032 24 µM -0.512628499050973 0.324523430666707 no 2292 0.304105606953706 3301 2847425 SGTC_485 niflumic acid 177 µM -0.512758139262572 0.324482593177257 no 2293 0.304060257539604 3395 4488 A COX2 inhibitor. SGTC_1121 fusaric acid 630.51 nM -0.513041366459163 0.324393382155398 no 2294 0.303961192383466 3267 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1923 st058458 19.1 µM -0.51352342833803 0.324241565277135 no 2295 0.30379261337462 3460 3534982 SGTC_840 0245-0196 390 µM -0.516626581822361 0.323264982155667 no 2296 0.302708428009933 3455 3827528 SGTC_80 0159-0065 512.242 µM -0.517385872647421 0.323026213266248 no 2297 0.302443409783551 3377 1548079 SGTC_2937 9044753 11.33 µM -0.518408162463465 0.322704856092701 no 2298 0.302086760434895 3335 6465530 YGL099W LSG1 SGTC_544 k015-0020 52.4 µM -0.518503198395284 0.322674988234415 no 2299 0.302053614556729 3346 3008304 SGTC_2014 4013930 200 µM -0.519031331365843 0.322509027644635 no 2300 0.30186944629403 3424 64556 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.519346400616854 0.322410037070099 no 2301 0.30175960073355 3367 1241132 A phosphatase inhibitor. SGTC_1108 betulinic acid 729.144 nM -0.519690889587842 0.322301817619124 no 2302 0.301639518867498 3338 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.522189456778906 0.321517356687556 no 2303 0.300769213046532 3354 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3334 9142812 21.919 µM -0.522808021047821 0.321323272260959 no 2304 0.300553928616007 3397 45283678 SGTC_1977 st070720 65.3 µM -0.523938081016578 0.320968823874115 no 2305 0.300160803574561 3413 682188 SGTC_298 1391-0729 10 µM -0.524895664390884 0.320668601176756 no 2306 0.299827861773484 3344 3237558 SGTC_1169 aniline yellow 25.8 µM -0.525248242375856 0.320558090027847 no 2307 0.299705316196639 3342 6051 A DNA damaging agent. SGTC_143 4032-1194 15.74 µM -0.52537782818181 0.320517476978369 no 2308 0.299660281743158 3376 1806963 SGTC_797 k781-0471 270 µM -0.52557222415422 0.320456556023632 no 2309 0.299592729812994 3313 23738129 SGTC_3102 9121669 49.47 µM -0.527671259870992 0.319799056248391 no 2310 0.298863762100926 3338 41905072 SGTC_1810 st050138 53 µM -0.528941848711949 0.319401333073126 no 2311 0.298422895103445 3406 3444541 SGTC_2367 9070478 135.38 µM -0.529016064785375 0.319378108171708 no 2312 0.298397152873085 3393 572802 SGTC_1061 3448-9325 110 µM -0.529422573310966 0.319250909481389 no 2313 0.298256171211823 3416 723482 SGTC_2165 5727197 32.143 µM -0.532277530952863 0.318358178007464 no 2314 0.297266895946836 3587 1361712 SGTC_946 3434-1334 87.4 µM -0.532284822011438 0.318355899475568 no 2315 0.297264371432793 3392 4047976 SGTC_1166 k206-0078 225 µM -0.533341433515373 0.318025770044579 no 2316 0.296898625510376 3398 5404595 SGTC_214 4373-3496 70 µM -0.53395694845404 0.317833524155021 no 2317 0.296685660061202 3475 3779166 SGTC_1481 3346-2004 36 µM -0.535667041925071 0.317299662596198 no 2318 0.296094342764659 3422 2770522 SGTC_183 3914-0051 30.55 µM -0.536702495312105 0.31697659655948 no 2319 0.295736566065364 3421 1596232 SGTC_654 1124-0271 80.9 µM -0.537937948555295 0.31659131218111 no 2320 0.295309944186477 3352 5403748 SGTC_1750 st081859 2.357 µM -0.541201692528882 0.315574449416055 no 2321 0.294184285513836 3459 5291695 SGTC_2712 st079126 47.7 µM -0.541856678699777 0.315370547581444 no 2322 0.293958621179928 3363 3152970 SGTC_646 4092-0839 27.3 µM -0.542142123276718 0.315281704246984 no 2323 0.293860301159502 3487 877796 SGTC_2159 5658611 73.75 µM -0.542405148502016 0.315199848289591 no 2324 0.293769716845998 3459 793844 SGTC_2760 etidronate 98.04 µM -0.542869225198349 0.315055445324282 no 2325 0.293609923125816 3345 3305 A chelator and antioxidant. SGTC_3019 9081971 49.47 µM -0.544587784957798 0.314520941327191 no 2326 0.293018528862984 3501 16451803 SGTC_877 0771-0151 33.1 µM -0.545588789482639 0.314209789309333 no 2327 0.292674316047193 3380 6166523 SGTC_2815 7968870 71.43 µM -0.547125705696165 0.313732311572642 no 2328 0.292146186554043 3405 2977326 YHR190W ERG9 SGTC_1932 st074806 40.9 µM -0.548981092915979 0.313156309080656 no 2329 0.291509212578964 3558 17251235 SGTC_2253 7938677 135.83 µM -0.554434554310374 0.311465930899615 no 2330 0.289640741729485 3500 2301972 SGTC_2047 4141938 200 µM -0.554923219035313 0.311314655422444 no 2331 0.289473589701336 3373 3807862 SGTC_3084 9116877 49.47 µM -0.555346714104048 0.311183580220841 no 2332 0.289328766178682 3399 27241325 SGTC_1337 1486-1011 40.3 µM -0.558176744971856 0.310308277622613 no 2333 0.288361849504125 3471 X1337 SGTC_1835 st008666 49.2 µM -0.558893229657159 0.310086845556891 no 2334 0.28811729513354 3340 690455 SGTC_2257 7960413 200 µM -0.561489944874765 0.309284899181468 no 2335 0.287231791541064 3420 2974689 YIL048W NEO1 SGTC_2074 5212007 75.395 µM -0.562469954864803 0.308982477338057 no 2336 0.286897934302245 3435 758611 SGTC_3016 9080866 49.47 µM -0.562541117633098 0.308960522216898 no 2337 0.286873698644919 3413 17066299 SGTC_762 1165-0429 115 µM -0.562924419817132 0.308842277653813 no 2338 0.286743175437124 3457 5967793 SGTC_1966 st070145 16.1 µM -0.564920539331889 0.308226816892701 no 2339 0.286063906311898 3384 3748532 SGTC_871 0574-0004 149 µM -0.566946171311208 0.307602807279719 no 2340 0.285375376863787 3349 9551173 SGTC_1753 st043925 64 µM -0.567458159663635 0.307445173807545 no 2341 0.285201472730939 3448 670181 SGTC_3273 9137859 49.47 µM -0.568156088902269 0.307230349222733 no 2342 0.28496449250373 3501 2377234 SGTC_1028 k015-0029 4.8 µM -0.568212705673465 0.307212925320252 no 2343 0.284945272531393 3470 4588309 SGTC_601 0986-0029 62.9 µM -0.56876625292649 0.307042593196056 no 2344 0.284757389718286 3478 24747981 SGTC_2551 apiole 73.87 µM -0.569331259293254 0.30686877792079 no 2345 0.284565678491233 3381 10659 A possible DNA adduct former. SGTC_162 k030-0015 37.8 µM -0.572029564206697 0.306039286266479 no 2346 0.28365097291302 3461 1809920 YMR134W ERG29 SGTC_174 3553-0389 74.3 µM -0.574945635079682 0.305143967743304 no 2347 0.282664032551873 3498 738071 SGTC_995 3931-2021 34.6 µM -0.575715364123976 0.304907832647824 no 2348 0.282403794337472 3449 730143 SGTC_1208 2323-2347 50.3 µM -0.576177685685868 0.304766042106627 no 2349 0.282247543143275 3485 5412760 SGTC_2728 chlorpromazine 9.18 µM -0.579452014584842 0.30376267021338 no 2350 0.281142107946742 3458 2726 A thorazine and dopamine antagonist. SGTC_1693 xanthone 101.9 µM -0.580441008921967 0.30345989694841 no 2351 0.280808628555775 3463 7020 An insecticide. SGTC_2097 5376186 200 µM -0.58256112539112 0.302811293781493 no 2352 0.280094390797477 3478 742755 SGTC_2070 5230947 200 µM -0.58467759867328 0.302164425081307 no 2353 0.279382259714238 3552 2835538 SGTC_1165 k072-0275 30.3 µM -0.58655983565439 0.301589668904706 no 2354 0.278749682076235 3543 6153523 YGL055W OLE1 SGTC_3330 9141424 71.43 µM -0.586906807225872 0.301483772055012 no 2355 0.278633148863726 3498 27261020 SGTC_147 4466-0538 29.23 µM -0.588313283951699 0.301054682287863 no 2356 0.27816101539884 3587 6742687 YHR072W ERG7 SGTC_1159 4092-0538 61.2 µM -0.589350619202623 0.300738387171015 no 2357 0.277813047458834 3524 717301 SGTC_2287 7945887 168.79 µM -0.589675232028602 0.300639439903822 no 2358 0.277704201693125 3485 1245853 SGTC_2857 9024691 58.44 µM -0.591377181914717 0.3001208985956 no 2359 0.277133862846359 3488 16478292 SGTC_3213 9129884 49.47 µM -0.593477554270169 0.299481526223705 no 2360 0.276430800077914 3434 17190742 SGTC_2011 4012611 177 µM -0.593958874247374 0.299335095071153 no 2361 0.276269809943885 3477 2049887 SGTC_742 0kpi-0133 140 µM -0.59558924377058 0.29883933201903 no 2362 0.275724832027173 3522 2728852 SGTC_3066 9117245 49.47 µM -0.596651324388167 0.29851657518125 no 2363 0.275370098510628 3479 17176980 SGTC_1725 st036284 20.55 µM -0.59704935379192 0.298395658455893 no 2364 0.275237215093583 3555 707914 SGTC_752 1896-0090 130 µM -0.597384854053288 0.298293754676896 no 2365 0.275125231758691 3518 772567 SGTC_3263 9137018 49.47 µM -0.601453657930967 0.29705917252451 no 2366 0.27376893451558 3479 43844957 SGTC_981 1488-1094 54.9 µM -0.601952300519816 0.296908032116672 no 2367 0.273602944472206 3506 3449522 SGTC_2463 5473429 200 µM -0.604661502953177 0.296087478492183 no 2368 0.27270196612175 3450 5399405 SGTC_1362 1611-0397 101 µM -0.604829864464961 0.296036520118451 no 2369 0.272646024072596 3510 27816 SGTC_2132 5317594 122.667 µM -0.605289632876311 0.295897381445794 no 2370 0.272493284287784 3495 794577 SGTC_2206 7254556 146.969 µM -0.605356436992998 0.295877167166373 no 2371 0.272471094810417 3505 4398905 SGTC_2890 9046729 58.44 µM -0.605547743035833 0.295819283317469 no 2372 0.272407556069478 3411 903329 SGTC_530 4358-1714 28 µM -0.606897665175254 0.295410982636469 no 2373 0.271959413852545 3517 1564641 SGTC_1638 st008370 60.6 µM -0.607826420914566 0.295130219580741 no 2374 0.271651301994021 3531 24207134 SGTC_3274 9138298 49.47 µM -0.608146492752455 0.295033490274488 no 2375 0.271545159427008 3508 17015756 SGTC_3223 9129970 49.47 µM -0.609221956177377 0.29470858016586 no 2376 0.271188664455524 3553 17248386 SGTC_652 0437-0092 114 µM -0.610656972784706 0.294275302001539 no 2377 0.270713348363825 3536 3091274 SGTC_2990 9074105 71.4286 µM -0.610726341773302 0.294254364705884 no 2378 0.270690382033741 3513 6502001 SGTC_1460 k062-0059 9.15 µM -0.612796033965666 0.293629996626328 no 2379 0.270005606802063 3467 1373085 SGTC_233 rapamycin 362 pM -0.614441913219877 0.293133919236082 no 2380 0.26946167313956 3546 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1447 4239-0816 81.9 µM -0.615914592160257 0.292690375152213 no 2381 0.268975445115606 3474 1341554 SGTC_1849 st056239 19.2 µM -0.620094568215203 0.291433143584321 no 2382 0.26759776404199 3449 5393181 SGTC_728 3030-5151 22.5 µM -0.621415060815898 0.291036496946444 no 2383 0.267163282579159 3575 3125388 SGTC_2336 9001819 198.65 µM -0.622117320106035 0.290825656631874 no 2384 0.266932363451758 3646 2989602 SGTC_2043 5101342 149 µM -0.623073770123951 0.290538615178127 no 2385 0.266618022770665 3504 678451 SGTC_1437 4092-1038 11.6 µM -0.62363717594132 0.29036959280061 no 2386 0.266432945092915 3542 3977136 SGTC_470 aa-861 153 µM -0.625176445750254 0.289908045011477 no 2387 0.265927629633293 3511 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2339 9000433 200 µM -0.62691345341322 0.289387619392305 no 2388 0.265357984024366 3477 2988954 SGTC_1330 1469-0054 61.8 µM -0.627830026798518 0.289113181468258 no 2389 0.265057646798144 3565 7102664 SGTC_1162 k048-0130 20.1 µM -0.628633424915724 0.288872730877885 no 2390 0.264794536250208 3553 6797406 SGTC_3075 9116269 49.47 µM -0.632255622118421 0.287789806889891 no 2391 0.263609928399005 3598 17015205 YNL244C SUI1 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.633154561180196 0.287521349472842 no 2392 0.263316357601626 3619 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1006 4099-6547 255 µM -0.634003898980585 0.287267813717896 no 2393 0.263039138793359 3586 3146833 SGTC_200 k038-0079 37.545 µM -0.634544902158916 0.287106374082682 no 2394 0.262862636370126 3516 3436683 SGTC_1569 carminic acid 40.6 µM -0.63563597318765 0.286780920585583 no 2395 0.262506858493824 3584 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1954 st077032 68.9 µM -0.636284567547708 0.286587535522349 no 2396 0.262295480869657 3521 698907 SGTC_1245 0418-0076 17.2 µM -0.638810774876853 0.285834911114356 no 2397 0.261473018960899 3565 6790114 SGTC_587 k089-0003 57 µM -0.64202875592003 0.284877552299211 no 2398 0.260427256097395 3538 9659696 SGTC_697 0508-1955 564 µM -0.643726040645004 0.284373222044414 no 2399 0.259876550283065 3590 6243113 SGTC_277 nystatin 15.5 µM -0.646081245483133 0.28367410536364 no 2400 0.25911337024811 3567 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.646885355583182 0.283435602770919 no 2401 0.25885307219766 3542 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1780 st038448 24.544 µM -0.648782883719912 0.282873168935643 no 2402 0.25823936116046 3622 728868 YDL195W SEC31 SGTC_3055 9094636 49.47 µM -0.649603488685652 0.282630104942961 no 2403 0.257974189501642 3632 25236176 SGTC_255 tunicamycin 200.472 nM -0.651155150461924 0.282170775764178 no 2404 0.257473169247058 3570 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_98 0074-0023 107.663 µM -0.651164705108778 0.28216794847259 no 2405 0.257470085688028 3567 3563821 SGTC_1085 doxorubicin 7.67 µM -0.651661119667806 0.282021074447993 no 2406 0.257309904844054 3618 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_412 gemfibrozil 100 µM -0.651978419885537 0.281927214221477 no 2407 0.257207546959634 3582 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3186 9110464 49.47 µM -0.652339234221468 0.281820500421312 no 2408 0.25709117758258 3606 17018021 SGTC_1949 st076024 69.1 µM -0.65263025618986 0.281734442471222 no 2409 0.256997337503178 3575 2921930 SGTC_660 4031-1742 102 µM -0.65305810897029 0.281607945362311 no 2410 0.256859408668072 3539 6738706 SGTC_2450 5739737 12.93 µM -0.653612411120386 0.28144410351847 no 2411 0.256680773079305 3603 2262825 SGTC_2441 5730946 39.09 µM -0.654073588981759 0.281307822619142 no 2412 0.25653219807468 3618 1774275 SGTC_440 fluspirilene 35.1 µM -0.654331160087775 0.281231722637101 no 2413 0.256449237381985 3674 3396 An atypical antipsychotic. SGTC_2069 5228469 200 µM -0.65457537344051 0.281159578416049 no 2414 0.256370591980015 3571 2835210 SGTC_1939 st074455 53.6 µM -0.657153933543392 0.280398379717727 no 2415 0.255540971362023 3638 1644229 SGTC_3082 9117008 49.47 µM -0.657649203025029 0.280252288987729 no 2416 0.255381785084731 3597 41448529 SGTC_431 k089-0097 107 µM -0.657689710026031 0.280240342179694 no 2417 0.255368767882476 3586 5499420 SGTC_1476 4112-3294 3.34 µM -0.658056764303947 0.280132097400449 no 2418 0.25525082828603 3645 704369 SGTC_2271 7849410 118.62 µM -0.660166216791331 0.279510410257165 no 2419 0.254573584644952 3603 972430 SGTC_1778 st046819 58.9 µM -0.661012314157537 0.27926124111361 no 2420 0.254302208240307 3644 671715 SGTC_1308 1187-1617 41.4 µM -0.661945343309005 0.278986596440705 no 2421 0.254003125346675 3612 2882570 SGTC_1307 1187-1599 12.2 µM -0.662186222448995 0.278915713061886 no 2422 0.253925941420214 3589 1538471 SGTC_2985 9022375 71.43 µM -0.662866666209488 0.278715526578712 no 2423 0.253707976096296 3658 4939335 SGTC_1148 3909-7663 27.7 µM -0.662903110574027 0.278704806624295 no 2424 0.253696304711319 3672 4084526 SGTC_141 0443-0274 32.331 µM -0.663000042365394 0.278676295528195 no 2425 0.253665263472045 3704 1627241 SGTC_2015 5119600 184 µM -0.663135615289293 0.278636421079434 no 2426 0.253621851221458 3611 2828786 SGTC_3252 9135871 49.47 µM -0.663590467567065 0.278502661099244 no 2427 0.253476229996405 3643 17682838 SGTC_3122 9126309 49.47 µM -0.663926780952989 0.278403780379944 no 2428 0.253368587326455 3659 17591206 SGTC_2174 5790901 200 µM -0.666788947204405 0.277562957536511 no 2429 0.252453476865268 3624 786020 SGTC_2627 acetyl isogambogic acid 100 µM -0.667025785515078 0.27749343681948 no 2430 0.252377831481103 3586 6857789 A caspase activator and apoptosis inducer. SGTC_1470 k295-0292 231 µM -0.667060792742734 0.277483161638205 no 2431 0.252366651300333 3645 5045612 SGTC_2225 6654152 15.4 µM -0.667133415322591 0.27746184634244 no 2432 0.252343458820422 3579 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2589 lobaric acid 100 µM -0.668326118337798 0.277111893223574 no 2433 0.251962722385141 3610 73157 A novel microtubule depolymerizer. SGTC_2517 totarol 10 µM -0.668815595067766 0.276968337518532 no 2434 0.25180655867382 3590 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1049 3226-0134 66 µM -0.669179841891018 0.276861533377459 no 2435 0.251690381752408 3655 5702385 SGTC_1375 2910-0797 186 µM -0.669275586866444 0.276833462466035 no 2436 0.251659848487242 3620 742508 SGTC_2911 7942208 15.64 µM -0.671397314763311 0.27621176339565 no 2437 0.250983727546644 3608 1243384 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.671725640573727 0.276115620111401 no 2438 0.250879187471197 3643 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2054 5233173 129 µM -0.673096493262687 0.275714372418306 no 2439 0.250442952366771 3635 6889 SGTC_2480 5767542 37.17 µM -0.673274795098669 0.27566220465755 no 2440 0.250386242408155 3634 2867358 SGTC_804 1595-0054 20.9 µM -0.673342300147465 0.275642455217472 no 2441 0.250364773802657 3625 761523 Stimulates phospholipase C. SGTC_598 3937-0236 20.2 µM -0.674490759476595 0.275306565814297 no 2442 0.249999679274407 3660 1379313 SGTC_2780 5215298 71.43 µM -0.675773874526443 0.274931532131161 no 2443 0.249592112150706 3634 2834131 SGTC_85 0868-0259 160.055 µM -0.677641339636858 0.274386152633688 no 2444 0.248999564063469 3587 83173 SGTC_747 3448-8087 38.7 µM -0.679488202711816 0.27384731554866 no 2445 0.248414290036648 3653 5168703 SGTC_2275 7947463 200 µM -0.679830601912515 0.273747475363202 no 2446 0.248305863775362 3603 1225414 SGTC_1173 0443-0020 122 µM -0.680702562754871 0.273493301626533 no 2447 0.248029857209276 3650 5331295 SGTC_2471 5466956 24.79 µM -0.682691416504752 0.272913994716306 no 2448 0.24740092735414 3608 724419 SGTC_872 0588-0139 234 µM -0.685242301955888 0.272171872870573 no 2449 0.246595517080839 3663 2047100 SGTC_67 0335-0847 266 µM -0.687594602229009 0.271488414977875 no 2450 0.245854054150745 3732 4552207 YOR254C SEC63 SGTC_1793 st048256 72.231 µM -0.687874270144983 0.271407214713 no 2451 0.245765980357504 3582 672022 SGTC_1892 st058411 7.36 µM -0.688101298633537 0.271341306958075 no 2452 0.245694496376709 3625 3934738 SGTC_21 0849-0113 22.993 µM -0.688697132527207 0.271168370688363 no 2453 0.245506940530909 3633 1560156 SGTC_3099 9120367 49.47 µM -0.689367863778943 0.270973761803165 no 2454 0.24529590065459 3689 24824940 SGTC_2936 9038235 15.59 µM -0.692155576352035 0.270165670121184 no 2455 0.244419816552915 3659 4749415 SGTC_2349 9023730 187.07 µM -0.692514690316542 0.270061659212754 no 2456 0.244307081851468 3653 4126287 SGTC_848 0368-0089 85.6 µM -0.693762011659767 0.269700550704521 no 2457 0.243915734844664 3643 762535 SGTC_196 k015-0023 18.111 µM -0.695641406437901 0.269156909510107 no 2458 0.243326714198561 3668 5211998 SGTC_2056 5235370 200 µM -0.695672150985306 0.269148020792902 no 2459 0.243317084952345 3654 5511916 SGTC_813 k007-0158 173 µM -0.696378601355719 0.268943815806312 no 2460 0.243095880201619 3684 6523916 SGTC_1748 st037455 53.6035 µM -0.69821935681964 0.268412096733194 no 2461 0.242520011431146 3669 580690 SGTC_1089 terbinafine 2.25 µM -0.698337941269954 0.268377860661936 no 2462 0.24248293838086 3661 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_452 diindolylmethane 8 µM -0.701041266150757 0.26759799005837 no 2463 0.241638631296602 3628 3071 Inhibits expression of several cancer promoting factors. SGTC_866 0495-0101 262 µM -0.702184694212158 0.267268471537409 no 2464 0.241281994762015 3657 635694 SGTC_2492 derrusnin 100 µM -0.702396251700403 0.267207526351696 no 2465 0.241216041107883 3619 1715307 Part of coumarin class of compounds. SGTC_2202 7226349 200 µM -0.702673278281504 0.267127731528468 no 2466 0.241129692094443 3638 844334 SGTC_922 1866-0035 480 µM -0.704912342013266 0.266483232763018 no 2467 0.240432394501575 3679 3156169 SGTC_3290 9121031 71.43 µM -0.705169391020721 0.266409293375034 no 2468 0.24035241367718 3681 17014854 SGTC_1396 3511-0007 98.6 µM -0.705622654883817 0.266278938656139 no 2469 0.240211415900356 3646 X1396 SGTC_1405 3909-7894 12 µM -0.705906006122364 0.2661974657222 no 2470 0.240123296116094 3689 7104060 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.70617242256755 0.266120873619255 no 2471 0.240040458981428 3742 5024745 SGTC_1745 st081495 74 µM -0.706547483050635 0.266013066342498 no 2472 0.239923867457979 3630 13842402 YBL026W LSM2 SGTC_822 1487-0950 154 µM -0.706601781937519 0.265997460519566 no 2473 0.239906990633664 3681 1958375 SGTC_2160 5660466 132.927 µM -0.709055308300148 0.265292786728594 no 2474 0.239145077678285 3644 2859134 SGTC_2162 5663267 200 µM -0.709775956259355 0.265085990660492 no 2475 0.238921540680838 3682 6456493 SGTC_1211 1056-0033 32.3 µM -0.709933343544459 0.265040837935489 no 2476 0.238872736098626 3699 6741922 SGTC_1649 st011737 51.3 µM -0.709997806077703 0.265022345453652 no 2477 0.238852748338689 3694 1761035 SGTC_1254 0550-0035 264 µM -0.710990302082169 0.264737709122815 no 2478 0.238545122716011 3745 15121435 SGTC_2820 7989630 71.43 µM -0.712126183290978 0.264412142443114 no 2479 0.238193320933898 3578 2984098 SGTC_3256 9138902 49.47 µM -0.713854299467785 0.263917220324632 no 2480 0.237658639540832 3719 17228773 SGTC_1646 st011709 75.6 µM -0.714166674485687 0.263827808411469 no 2481 0.23756206062802 3662 5757843 SGTC_1594 piperine 70.1 µM -0.716389088356584 0.263192127257944 no 2482 0.236875565343819 3698 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_295 k015-0027 31 µM -0.716842093756305 0.263062649349394 no 2483 0.236735767618977 3667 3887424 SGTC_3143 9086658 49.47 µM -0.716849493542309 0.263060534614346 no 2484 0.236733484417529 3763 25236626 SGTC_1994 st072947 40.9 µM -0.717394874050711 0.26290469790885 no 2485 0.236565240792298 3726 5286565 YDL195W SEC31 SGTC_3067 9117431 49.47 µM -0.718323092849035 0.262639577787345 no 2486 0.236279047288602 3723 17150885 SGTC_619 1652-1634 108 µM -0.721269050461066 0.261799053198485 no 2487 0.235371997530448 3676 5400454 SGTC_2455 5377712 9.75 µM -0.721297792659171 0.261790859433015 no 2488 0.235363157388449 3680 2243908 SGTC_1077 5-fluorocytosine 377 nM -0.722640598751136 0.261408201785591 no 2489 0.234950359345635 3727 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3314 9135860 59.4275 µM -0.72291481592759 0.261330093819074 no 2490 0.234866110230576 3688 25252478 SGTC_3129 9127257 49.47 µM -0.723731848131938 0.261097441620062 no 2491 0.234615188353471 3686 837894 SGTC_1843 st055809 45.5 µM -0.723997916830739 0.261021700803171 no 2492 0.234533506993561 3711 16413835 SGTC_305 1682-2595 20.8 µM -0.724135368478204 0.260982577364112 no 2493 0.234491316394913 3737 226033 SGTC_594 1487-1584 10.8 µM -0.726171855016158 0.260403277149249 no 2494 0.233866711787609 3700 5013332 SGTC_2490 carminic acid 95.39 µM -0.726652309027676 0.260266703529121 no 2495 0.233719487716426 3649 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2100 5377183 190 µM -0.728133552917834 0.259845878296838 no 2496 0.233265918145884 3753 2844202 SGTC_1141 3253-0389 52.6 µM -0.72821157475513 0.259823721826773 no 2497 0.233242040741747 3685 5402031 SGTC_932 2857-0803 154 µM -0.728446217031911 0.259757094502378 no 2498 0.233170240194106 3808 674898 SGTC_2139 5578692 56.4705 µM -0.731181555604811 0.25898103853929 no 2499 0.232334132298401 3662 650991 YMR113W FOL3 SGTC_186 3455-3465 67.277 µM -0.732222791121883 0.25868594008551 no 2500 0.23201629783409 3678 755278 SGTC_1431 4049-0260 9.09 µM -0.734250860434593 0.258111661373786 no 2501 0.231397930416149 3698 3854841 SGTC_2394 5221648 200 µM -0.735794508992385 0.257674997269032 no 2502 0.230927881703018 3808 788586 SGTC_2281 7943571 200 µM -0.736658272172073 0.257430825189168 no 2503 0.230665094277565 3826 1244024 SGTC_1021 4476-0760 85.3 µM -0.739741059567132 0.256560351498042 no 2504 0.229728564443506 3746 746768 SGTC_3249 9135183 49.47 µM -0.741579327780169 0.256042018061358 no 2505 0.229171126123291 3756 4902779 SGTC_3141 9094609 49.47 µM -0.744990074306496 0.255081744530771 no 2506 0.228138860143219 3714 25236309 YDL196W YDL196W SGTC_561 1550-0330 72.9 µM -0.746178218268412 0.254747673282464 no 2507 0.227779882089929 3708 6812934 SGTC_1866 st057638 64 µM -0.747511753611119 0.254372995257548 no 2508 0.227377355335813 3738 688802 SGTC_1842 st055362 61.2 µM -0.749989900396063 0.253677488247831 no 2509 0.226630393757182 3746 676032 SGTC_76 0433-0009 400.328 µM -0.750065376268218 0.253656321166652 no 2510 0.226607665617994 3830 2841569 SGTC_2608 thymoquinone 42.66 µM -0.750083108625721 0.253651348291439 no 2511 0.22660232603873 3709 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_100 0086-0128 49.5915 µM -0.75094800303355 0.253408858844761 no 2512 0.226341974684539 3756 93297 SGTC_2707 st078556 66.6 µM -0.751331496308863 0.25330137827896 no 2513 0.226226589254728 3738 17250899 SGTC_3005 9076496 71.4286 µM -0.751534707068988 0.253244434695237 no 2514 0.226165460689033 3772 21368410 SGTC_753 1322-0200 289 µM -0.752603575065287 0.252945028068798 no 2515 0.225844084337935 3775 5403907 SGTC_1672 st016598 6.51 µM -0.753347236454933 0.252736826839196 no 2516 0.225620640234616 3791 4665860 YNL267W PIK1 SGTC_2941 9056145 11.23 µM -0.753349331418257 0.252736240444454 no 2517 0.225620010948533 3638 2119517 SGTC_850 0388-0143 75.9 µM -0.753851085833838 0.252595816544975 no 2518 0.225469322324838 3728 67273 SGTC_3013 9080133 71.4286 µM -0.754549833758374 0.252400329393877 no 2519 0.225259566871244 3811 17050193 SGTC_3106 9121286 49.47 µM -0.755762730051727 0.252061189530339 no 2520 0.22489573300767 3760 15943471 SGTC_2152 5568786 200 µM -0.756039553119515 0.25198382030173 no 2521 0.224812740797073 3738 5399883 SGTC_245 methotrexate 289.6 µM -0.758374227127823 0.251331801540266 no 2522 0.224113491181698 3758 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3356 9151811 4.48 µM -0.758870612445756 0.251193288027339 no 2523 0.223964980044954 3748 1859254 YPR165W RHO1 SGTC_721 1187-1332 279 µM -0.759082617835666 0.251134141429435 no 2524 0.223901568216464 3701 25730 SGTC_3245 9134821 49.47 µM -0.760297185954497 0.250795435612499 no 2525 0.223538481787547 3784 17014901 SGTC_188 3229-0966 278.469 µM -0.760312727633528 0.250791103082422 no 2526 0.22353383788519 3832 5722370 SGTC_1347 1493-0251 600 nM -0.761321252416006 0.250510042913101 no 2527 0.223232604860546 3809 3986378 SGTC_2359 9039622 200 µM -0.762306365269134 0.250235668503672 no 2528 0.222938587881812 3733 6463596 SGTC_104 0074-0074 590.992 µM -0.763339514715313 0.249948086196502 no 2529 0.222630471011529 3616 3943124 SGTC_1563 conessine 56.1 µM -0.764258599112807 0.249692401962824 no 2530 0.222356575988094 3834 441082 An anti-amoebic, histamine inhibitor. SGTC_2907 7721985 69.9 µM -0.764853162765858 0.249527071644183 no 2531 0.222179493369847 3780 3267881 SGTC_548 1436-0017 110 µM -0.768184745829455 0.248601735452135 no 2532 0.221188717357551 3827 9677137 SGTC_2329 6138490 200 µM -0.768845587061692 0.248418406477716 no 2533 0.220992491310389 3881 720019 SGTC_2130 NSC 7 2.4545 µM -0.769846464798094 0.248140882663956 no 2534 0.220695486769952 3821 21448 SGTC_2485 5633444 17.78 µM -0.771566569557182 0.247664317847751 no 2535 0.220185590341652 3812 5724239 SGTC_1130 3454-2858 15.9 µM -0.771758749347659 0.247611103717176 no 2536 0.220128663829315 3829 715628 YIL048W NEO1 SGTC_2381 9035592 200 µM -0.772659794047657 0.247361688033034 no 2537 0.219861873586715 3816 4749657 SGTC_1818 st052136 56.3 µM -0.77335098456138 0.247170452560529 no 2538 0.219657344891227 3656 674169 SGTC_425 3825-7017 13.1 µM -0.774422608607455 0.246874116848255 no 2539 0.219340459033913 3894 3397440 SGTC_1808 st050063 61.5 µM -0.77463400162724 0.246815682896207 no 2540 0.219277979848228 3767 4011993 SGTC_1895 st058434 18.3 µM -0.776332744207346 0.246346379835344 no 2541 0.218776272094826 3780 5393175 SGTC_837 0091-0265 12.5 µM -0.776663826067097 0.246254969244388 no 2542 0.218678567134691 3772 759367 SGTC_317 4495-0002 170 µM -0.776722734863886 0.246238706629158 no 2543 0.218661185300106 3821 15991618 SGTC_1387 3342-1166 1.8 µM -0.776723084299242 0.246238610164252 no 2544 0.218661082196866 3797 3418228 SGTC_2291 7917025 104.35 µM -0.782078820519557 0.244762491914741 no 2545 0.217084126439614 3754 2964612 SGTC_1355 1499-0035 1.68 µM -0.782968048843684 0.244517869695257 no 2546 0.21682293750674 3795 1548538 SGTC_3343 9148379 18.9835 µM -0.784381236237293 0.244129380107726 no 2547 0.216408222540054 3862 1955036 SGTC_3158 9100007 49.47 µM -0.785674449340715 0.243774163694554 no 2548 0.216029117900254 3832 19297233 SGTC_1160 4092-0570 10.5 µM -0.786947318892403 0.243424807816932 no 2549 0.215656352913798 3801 4994975 SGTC_1132 3456-3614 2.5 µM -0.787072795380988 0.243390383789018 no 2550 0.215619626822002 3911 3125502 SGTC_1831 st055328 12 µM -0.78809148709927 0.243111006734271 no 2551 0.215321597138787 3786 1103068 SGTC_1360 1598-0022 39.8 µM -0.788576924757987 0.242977936083102 no 2552 0.215179661043077 3879 761525 SGTC_1045 1348-1485 165 µM -0.789010740824852 0.242859049553953 no 2553 0.215052864441055 3831 6810614 SGTC_1852 st056254 31.4 µM -0.79133116485493 0.242223676238444 no 2554 0.214375383423012 3748 442583 SGTC_2076 5212012 200 µM -0.792240140009265 0.241975028528426 no 2555 0.214110333829159 3718 604802 SGTC_532 1548-0774 215 µM -0.792514730070322 0.241899942392894 no 2556 0.21403030317292 3952 5932993 SGTC_2425 5628681 7.85 µM -0.798034711926126 0.240393198258721 no 2557 0.212425173361768 3902 5714958 SGTC_1924 st058459 75.1 µM -0.798553500360866 0.240251852121354 no 2558 0.212274679712967 3761 688683 SGTC_2293 7624732 200 µM -0.799815526611091 0.239908196810461 no 2559 0.211908842909095 3754 894453 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.800451002422214 0.239735255487756 no 2560 0.211724770562673 3870 115019 SGTC_1656 st012921 11 µM -0.801020388703498 0.239580357875209 no 2561 0.211559921263841 3764 6732821 SGTC_1237 0330-0133 46.1 µM -0.802063404752748 0.239296754308461 no 2562 0.211258141169726 3774 X1237 YHR072W ERG7 SGTC_416 estradiol valerate 100 µM -0.802408846931881 0.239202866540426 no 2563 0.211158248596656 3874 13791 A steroid. SGTC_3092 9117248 49.47 µM -0.804199439311153 0.238716523977006 no 2564 0.210640901286658 3901 17141857 SGTC_715 0868-0130 184 µM -0.805099035953619 0.238472388985301 no 2565 0.210381266040945 3855 2876258 SGTC_2000 st075254 36.4 µM -0.805155190335632 0.238457154189901 no 2566 0.210365065391156 3790 17234175 SGTC_2087 5276107 200 µM -0.805331906314041 0.238409214271211 no 2567 0.210314087262937 3808 144405 SGTC_3255 9139072 49.47 µM -0.805829269137152 0.238274316869797 no 2568 0.210170649503688 3841 17646060 SGTC_2726 cimetidine 79.27 µM -0.808162277071213 0.237642104394068 no 2569 0.209498585236524 3836 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_318 1488-0629 67.2 µM -0.808183259745597 0.237636422562433 no 2570 0.2094925465476 3897 3662576 SGTC_1888 azatryptophan 97.5 µM -0.809886050015082 0.23717557796123 no 2571 0.209002835064261 3886 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2258 7960471 200 µM -0.810590265994231 0.236985131960569 no 2572 0.20880050433724 3877 2974708 SGTC_811 0416-0114 265 µM -0.811571380612895 0.23671994252749 no 2573 0.208518809402565 3909 6612453 SGTC_1559 coumarin 343 70.1 µM -0.812597002629072 0.236442897592908 no 2574 0.208224575323662 3839 108770 A hepatotoxic, DNA x-linker. SGTC_1455 4262-0120 131 µM -0.815065163920738 0.235776920552223 no 2575 0.207517505373007 3966 1529587 SGTC_315 k915-0449 187 µM -0.815106881482653 0.235765672915169 no 2576 0.207505566484142 3882 20970215 YNL149C PGA2 SGTC_2012 4023501 200 µM -0.816885474098026 0.235286414810047 no 2577 0.206996939856351 3874 3477460 SGTC_171 k064-0041 9.68 µM -0.818827226620592 0.234763806475752 no 2578 0.206442497349755 3881 53325 SGTC_2383 9036125 200 µM -0.819732973311203 0.234520251109881 no 2579 0.206184174233359 3774 79580 SGTC_299 1273-0059 1.44 µM -0.820987913000894 0.234183028834388 no 2580 0.205826576533407 3781 2848077 SGTC_925 2064-1272 59.6 µM -0.821231410434398 0.234117628310948 no 2581 0.205757234079428 3845 6815817 SGTC_707 0865-0008 204 µM -0.823058736541916 0.233627153076139 no 2582 0.2052372962765 3858 723043 SGTC_1530 rhein 70.4 µM -0.823662582152477 0.233465199336321 no 2583 0.205065652952195 3910 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_227 fluconazole 33.516 µM -0.824794678854233 0.233161734492106 no 2584 0.204744084089482 3860 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2311 7694451 200 µM -0.825461553751662 0.23298307748677 no 2585 0.204554800620943 3835 2163142 SGTC_2818 7996756 12.99 µM -0.826005938503242 0.232837292197727 no 2586 0.204400361556457 3872 2241621 SGTC_824 1304-0008 100 µM -0.827269879599817 0.232499006496967 no 2587 0.204042055939031 3894 768245 SGTC_3049 9092223 49.47 µM -0.827400768548967 0.232463990535613 no 2588 0.204004972560744 3854 8623917 SGTC_173 1273-0061 2.693 µM -0.828187086215219 0.232253693275826 no 2589 0.20378227804853 3873 2847414 YPL266W DIM1 SGTC_398 bronopol 33.3 µM -0.828233009055549 0.232241414683315 no 2590 0.20376927663442 3776 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1744 st037937 38.9 µM -0.828789674911016 0.232092605206739 no 2591 0.20361171588408 3951 1016152 SGTC_149 3970-0822 46.1 µM -0.829060740338849 0.232020162457027 no 2592 0.203535018838476 3881 3114250 YBL034C STU1 SGTC_2823 7987624 58.44 µM -0.829389047647414 0.231932438566348 no 2593 0.203442148474118 3863 2239440 SGTC_1244 0416-0015 52.5 µM -0.829693790343251 0.23185102768512 no 2594 0.203355966608228 3859 96201 SGTC_2744 captopril 92.04 µM -0.829881964909077 0.231800765497454 no 2595 0.203302761331448 3833 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_464 bw-b 70c 158 µM -0.830166811155585 0.231724693462733 no 2596 0.203222238499399 3947 5353454 SGTC_1354 1498-1681 81 µM -0.832781889352089 0.231026951970293 no 2597 0.202483875287634 3919 5754243 SGTC_3086 9117350 49.47 µM -0.833122147232369 0.230936252440617 no 2598 0.202387922072103 3784 2679265 SGTC_876 0720-0963 56.8 µM -0.833464362462458 0.230845051213203 no 2599 0.202291444312834 3912 765861 SGTC_551 k048-0028 34.9 µM -0.833684537196252 0.23078638472259 no 2600 0.202229386913027 3861 6836383 SGTC_1727 st034309 9.9045 µM -0.833937012632901 0.230719121823396 no 2601 0.202158239410302 4003 870305 SGTC_1965 Pectolinarigenin 58.4 µM -0.834115687886436 0.230671526917446 no 2602 0.202107897827975 3858 5320438 An anti-inflammatory. SGTC_2114 5491910 81.25 µM -0.83420294942698 0.230648284479052 no 2603 0.202083314698735 3953 2849228 SGTC_2918 7977171 22.06 µM -0.837038000997353 0.229893870082018 no 2604 0.201285604012567 3809 2236483 SGTC_1713 st033146 12.748 µM -0.838630257805491 0.229470773013597 no 2605 0.200838412882997 3840 674619 SGTC_2412 st077135 33.4 µM -0.839242817269219 0.22930811901907 no 2606 0.200666532252609 3995 13258915 SGTC_2571 chrysanthemic acid 100 µM -0.839770115959355 0.229168156250999 no 2607 0.200518646050688 3920 2743 An insecticide. SGTC_81 0411-0046 9.971 µM -0.84023135116598 0.229045768241584 no 2608 0.200389341695183 3800 12925265 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.84187311877556 0.228610425569659 no 2609 0.199929489209814 3922 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1444 4112-3581 28 µM -0.842446084108944 0.228458603503937 no 2610 0.199769153423537 3920 2877249 SGTC_1030 k029-0042 36.7 µM -0.842509731222061 0.228441742042623 no 2611 0.199751347504669 3886 6080581 SGTC_1501 4491-0275 38.4 µM -0.843498355935555 0.228179924323472 no 2612 0.199474892425539 3832 5104718 SGTC_1324 1418-0026 34.4 µM -0.843725859786368 0.228119698311854 no 2613 0.199411306767855 3944 1372513 SGTC_1412 3909-8563 178 µM -0.84572792842794 0.227590085818727 no 2614 0.198852269632936 3964 23767530 SGTC_2122 5258151 111.688 µM -0.84646237036325 0.227395975668465 no 2615 0.198647428667721 3897 2173356 SGTC_448 monastrol 171 µM -0.8470457740796 0.227241850822269 no 2616 0.198484804037838 3814 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_395 anisomycin 6.25 µM -0.847562036510803 0.227105512616992 no 2617 0.198340962144492 3904 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_176 1486-1328 72.834 µM -0.848304833595364 0.226909430481165 no 2618 0.198134113195943 3963 22310231 SGTC_3072 9116419 49.47 µM -0.848968445493738 0.226734332288462 no 2619 0.19794942538765 3934 17170162 SGTC_1570 verbenone 133 µM -0.849747183794971 0.226528954533032 no 2620 0.19773282975772 3938 29025 A natural terpanoid with antifungal properties. SGTC_2591 skatole 100 µM -0.850904719891279 0.226223870073359 no 2621 0.197411141378894 3963 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3353 9151644 39.2805 µM -0.852593213313408 0.22577926113202 no 2622 0.196942463724885 3968 4909158 SGTC_1017 4239-0030 168 µM -0.853011354258032 0.225669233935819 no 2623 0.196826503857436 3950 1149593 SGTC_3207 9114163 49.47 µM -0.853668561463151 0.225496361549698 no 2624 0.196644329129611 3919 849233 SGTC_340 k038-0059 454 µM -0.856985213843509 0.224625090803246 no 2625 0.19572652818108 3900 23733424 SGTC_194 1486-1323 56.904 µM -0.858117612259934 0.224328052339955 no 2626 0.195413761528229 3957 5178754 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.858697483193413 0.224176033257077 no 2627 0.195253719692493 3924 616764 SGTC_771 0250-0039 27.3 µM -0.86064838355742 0.223665014546581 no 2628 0.194715864739694 3878 3005115 SGTC_964 1287-0107 19.4 µM -0.860817907079275 0.223620640867098 no 2629 0.194669170426601 3948 51516812 YPR165W RHO1 SGTC_2214 7179297 48.276 µM -0.861546009513689 0.223430113135552 no 2630 0.194468696133743 3929 769744 SGTC_2729 fluphenazine 10.66 µM -0.862806428559512 0.223100508760115 no 2631 0.194121952030184 3848 3372 An atypical antipsychotic. SGTC_1913 st060213 96.1 µM -0.863350915490592 0.222958209034455 no 2632 0.193972279016332 3973 688959 SGTC_3146 9095609 49.47 µM -0.863361371893084 0.222955476796842 no 2633 0.193969405363394 3975 17173999 SGTC_1472 k841-0093 193 µM -0.865518235764813 0.222392300306115 no 2634 0.193377205689512 4026 X1472 SGTC_1602 st001878 87.6 µM -0.866608856335504 0.222107838663839 no 2635 0.193078179677699 3935 595405 YLR310C CDC25 SGTC_1224 0823-0416 294 µM -0.867243756644946 0.221942336170185 no 2636 0.192904232992434 4001 3598164 SGTC_910 3454-3003 490 µM -0.868795042297685 0.221538251510238 no 2637 0.192479622643378 3863 820824 SGTC_1389 3405-0187 19 µM -0.872123994918348 0.220672534516809 no 2638 0.191570368652262 3897 799890 SGTC_93 0109-0045 59.227 µM -0.872421178195417 0.220595344295814 no 2639 0.191489325579464 4015 88733 SGTC_349 k015-0014 24 µM -0.872793688193556 0.220498610604655 no 2640 0.191387770279506 3927 2196908 SGTC_1604 st002052 72.4 µM -0.877632373482739 0.219244307466051 no 2641 0.190071627445877 4006 6254834 YHR062C RPP1 SGTC_3184 9108758 49.47 µM -0.878147210468676 0.219111091216878 no 2642 0.189931917768109 3954 902885 SGTC_2133 5320837 200 µM -0.879254852529685 0.218824641980841 no 2643 0.189631554550028 3970 2841355 SGTC_362 0310-0100 9.03 µM -0.879741236748117 0.218698925428113 no 2644 0.18949975239881 4031 790235 SGTC_2816 7982706 58.44 µM -0.880008847410953 0.218629773378758 no 2645 0.18942725834117 4005 2981853 SGTC_2693 st077581 40.7 µM -0.880823315051032 0.218419387982336 no 2646 0.189206729183608 4001 25238761 SGTC_1326 1431-2094 10.8 µM -0.881056739959303 0.218359113424427 no 2647 0.18914355509456 3931 616278 SGTC_2930 9013230 14.89 µM -0.881227329052176 0.218315070277535 no 2648 0.189097395099133 3981 2995857 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.881618775872595 0.218214024841648 no 2649 0.188991499061328 3951 6728940 SGTC_1565 sinapyl alcohol 95.1 µM -0.882172351373543 0.218071174618321 no 2650 0.188841805583732 3990 5280507 A phenol propionate derived from cinnamic acid. SGTC_1769 st044406 64.4 µM -0.884959757130789 0.217352703801923 no 2651 0.188089168225501 3944 670903 SGTC_2279 7948423 32.93 µM -0.886190270067981 0.217035966995938 no 2652 0.187757502939931 3875 1247112 SGTC_2796 7949634 45.45 µM -0.887012367234541 0.216824506039673 no 2653 0.187536121074739 3900 2971588 SGTC_2303 7774051 200 µM -0.889230204190076 0.216254625511924 no 2654 0.186939686609532 3945 2953184 SGTC_3319 9138450 16.7555 µM -0.889401964835404 0.216210527256695 no 2655 0.186893544691203 3903 2029690 SGTC_2764 methyldopa 94.69 µM -0.892656076209429 0.215376042912869 no 2656 0.186020689617838 3947 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1674 st016616 23.6 µM -0.893780403387712 0.215088155370614 no 2657 0.185719698090441 3932 625830 SGTC_34 0469-0683 81.75 µM -0.893978288700401 0.21503750933952 no 2658 0.185666753867722 3932 3690923 SGTC_2992 9074591 71.4286 µM -0.89413663062552 0.214996988883662 no 2659 0.18562439622486 3909 17741321 SGTC_1287 0971-0001 34.6 µM -0.894394785030361 0.214930935445205 no 2660 0.185555350859163 3945 4665869 SGTC_2217 6934799 96.0675 µM -0.894415222402411 0.214925706680243 no 2661 0.185549885408949 3887 675606 SGTC_2840 9008771 71.43 µM -0.894643988704376 0.214867183393928 no 2662 0.185488714555467 3919 2992978 SGTC_1269 0831-0796 3.05 µM -0.907824240141856 0.211511054606934 no 2663 0.181985544638451 4016 927758 SGTC_2456 5770359 74.46 µM -0.909913226589814 0.210981961649419 no 2664 0.181434136905822 4016 3118787 SGTC_1635 st007035 42.4 µM -0.910558606587203 0.210818658532792 no 2665 0.181263994453932 3959 3716403 SGTC_2098 5376439 882.5 nM -0.91065190435109 0.2107950571558 no 2666 0.181239406500091 4016 2844116 SGTC_1550 gossypolone 36.6 µM -0.911643567376322 0.210544293632811 no 2667 0.180978189960013 3991 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2223 6903751 107.57 µM -0.911762777147927 0.210514160646133 no 2668 0.180946804495964 3947 5598863 SGTC_2806 7952793 58.44 µM -0.912385916191543 0.210356689250843 no 2669 0.180782800411134 4050 2972490 SGTC_2238 6671620 73.2395 µM -0.914133507534678 0.209915430370929 no 2670 0.180323348841391 3928 729941 SGTC_3147 9097027 49.47 µM -0.915082465063682 0.209676050979001 no 2671 0.180074169814767 3998 25236841 SGTC_2564 betulinic acid 100 µM -0.917714060689682 0.209013057915622 no 2672 0.179384292225104 4064 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2141 5621638 7.665 µM -0.919799890532266 0.208488440999797 no 2673 0.178838670289919 4026 2856238 SGTC_2427 5545055 42.75 µM -0.921172396423676 0.20814365952583 no 2674 0.178480213705067 3964 5372858 SGTC_2696 st077691 74.316 µM -0.924511865002774 0.207306172230894 no 2675 0.177609938434979 4051 757133 SGTC_1872 amphotericin b 148 nM -0.925886049169471 0.206962127473558 no 2676 0.177252601046567 4016 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2044 5102272 200 µM -0.927660456203108 0.206518381941587 no 2677 0.176791863439963 4024 592666 SGTC_2654 protoveratrine a 100 µM -0.928183352155708 0.206387723179074 no 2678 0.176656234274631 3987 5702278 A heart drug and vasodilator. SGTC_453 enantio-paf c16 10 µM -0.929051369160537 0.206170935382937 no 2679 0.176431232640158 3871 13871343 A lipid and platelet activating factor SGTC_2428 5615643 7.78 µM -0.930971317344928 0.205691906909832 no 2680 0.175934200658161 4050 2253075 SGTC_2975 9084847 53.72 µM -0.931840792147063 0.205475189802498 no 2681 0.175709404911596 4079 27211724 SGTC_2790 5423970 71.43 µM -0.933646320922504 0.205025594028786 no 2682 0.175243181493942 4097 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2288 7946289 167.31 µM -0.935145106636752 0.204652825080057 no 2683 0.17485676170472 4075 1246052 SGTC_2979 9012552 45.46 µM -0.935521250557014 0.204559336163951 no 2684 0.174759868515924 4044 17100905 SGTC_347 4534-1311 26.2 µM -0.936695165741332 0.2042677281748 no 2685 0.174457691822531 4018 2862016 SGTC_1583 clindamycin 39.6 µM -0.939997413559983 0.203448757420588 no 2686 0.17360944368705 4000 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_32 0928-0142 34.1 µM -0.940194521957853 0.203399935772853 no 2687 0.173558895601481 3997 2244242 SGTC_353 1988-1175 58.3 µM -0.94121675158928 0.203146852543392 no 2688 0.17329689695227 3865 2788357 SGTC_1760 st045453 10.4495 µM -0.943831583244875 0.20250032953376 no 2689 0.172627859172935 4086 3323419 YIL048W NEO1 SGTC_2267 7931562 200 µM -0.944942716512896 0.20222597217492 no 2690 0.172344060907589 3941 934880 SGTC_3247 9135149 49.47 µM -0.945148670377912 0.202175143165615 no 2691 0.172291490257931 4009 8934436 YOR116C RPO31 SGTC_1928 4'-methoxychalcone 40.3 µM -0.94707985629401 0.201698902247198 no 2692 0.171799044209466 4072 641818 SGTC_579 4491-1009 110 µM -0.947539651895271 0.201585613267937 no 2693 0.171681930466291 4148 1271041 SGTC_596 1155-0152 116 µM -0.949556184734851 0.201089210389188 no 2694 0.171168905365826 4027 280313 SGTC_218 alverine citrate 93.75 µM -0.955321656292391 0.199673994457044 no 2695 0.169707529542807 4071 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1365 1672-3266 55.4 µM -0.955694231809857 0.199582747176562 no 2696 0.169613368786088 4080 6415873 SGTC_1901 st060216 58.6 µM -0.957911971404963 0.199040121142315 no 2697 0.169053574641277 4014 688792 SGTC_168 3970-0862 530.542 µM -0.958340152414167 0.198935458311041 no 2698 0.168945631489534 4015 3135186 SGTC_113 0099-0221 2.5 µM -0.960082356544291 0.19850994315054 no 2699 0.168506883727782 3964 89219 SGTC_286 k060-0067 22.9 µM -0.960619095021274 0.19837896109834 no 2700 0.168371862004862 4039 5985051 SGTC_1391 3442-0225 151 µM -0.961786832452883 0.19809417451452 no 2701 0.168078346862552 4018 5227075 SGTC_1809 st050081 57.6 µM -0.962853575545752 0.19783423420123 no 2702 0.167810504978132 4129 5036894 SGTC_1356 1502-0781 85.8 µM -0.965000367388214 0.197311736362433 no 2703 0.167272313884099 4020 567702 SGTC_127 0180-0333 59.125 µM -0.967117785711519 0.196797206106995 no 2704 0.166742577635678 3922 771601 SGTC_2033 5192550 145 µM -0.967260614818261 0.196762528072621 no 2705 0.166706883627018 4038 182073 SGTC_3070 9117005 49.47 µM -0.967286420383586 0.196756263033776 no 2706 0.166700435158802 4118 8779016 SGTC_497 capsazepine 133 µM -0.967510723626469 0.196701812096949 no 2707 0.166644391535931 4016 2733484 A calcium channel blocker. SGTC_258 haloperidol 50.781 µM -0.968150289940435 0.196546603719492 no 2708 0.166484658510103 4064 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1329 1447-1697 50.6 µM -0.968692118020646 0.196415172293514 no 2709 0.166349413177488 4050 2840515 SGTC_2813 7971799 71.43 µM -0.969098806897458 0.19631655663565 no 2710 0.166247946471945 4103 2234054 SGTC_1332 1480-0653 17.5 µM -0.97043625698929 0.195992457740718 no 2711 0.16591454176344 4058 5749438 SGTC_2752 diclazuril 33.15 µM -0.971572840670639 0.195717289281564 no 2712 0.165631549709831 4023 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1079 idarubicin 2.36 µM -0.971644492458162 0.195699950147526 no 2713 0.165613719969499 4064 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1722 st034304 3.6505 µM -0.975449636491378 0.194780477257224 no 2714 0.164668636155923 4052 4036148 YLR033W RSC58 SGTC_2526 patulin 37.61 µM -0.977820862510707 0.194208826790148 no 2715 0.16408146540862 4107 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1728 st035614 33.7865 µM -0.97879406796442 0.193974504395378 no 2716 0.163840870670945 4039 15945546 SGTC_991 3996-0057 64.7 µM -0.979624178902188 0.193774771620382 no 2717 0.163635832622574 4130 715343 SGTC_678 1218-2179 85.9 µM -0.979731935308002 0.193748853576835 no 2718 0.16360922892808 4043 6820081 YOR116C RPO31 SGTC_1177 0983-0204 23.6 µM -0.980840497560352 0.193482340047987 no 2719 0.163335701987978 4099 766818 SGTC_1138 3761-0006 1.03 µM -0.981619126544908 0.193295280759305 no 2720 0.16314376058074 4076 12061087 SGTC_2095 5432005 200 µM -0.987990075297906 0.191768861578394 no 2721 0.161578754414462 4082 783734 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.99264473716935 0.190658328283671 no 2722 0.160441557443463 4057 756377 SGTC_1560 lithocholic acid 53.1 µM -0.994731229616466 0.190161806047838 no 2723 0.159933500649492 3956 9903 A bile acid which acts as a detergent. SGTC_803 4488-1585 147 µM -0.997106030204416 0.189597642966786 no 2724 0.159356523158026 4075 747204 SGTC_3267 9137951 49.47 µM -0.997763146217587 0.189441719041099 no 2725 0.159197112413382 4115 16643986 SGTC_157 1348-1695 65.819 µM -0.998602578362199 0.189242649022702 no 2726 0.158993625316208 4042 5380510 SGTC_1345 1488-0192 31.4 µM -1.00010890709048 0.188885748589409 no 2727 0.158628903038846 4142 658348 SGTC_1641 st009299 47.1 µM -1.00012060469444 0.188882978653584 no 2728 0.158626072885955 3982 4046054 SGTC_251 melphalan 456.522 µM -1.00026700314168 0.188848314328823 no 2729 0.158590655612943 4112 460612 A DNA alkylator. SGTC_3175 9106517 49.47 µM -1.00146934452315 0.188563771437114 no 2730 0.158299976776699 4111 41468073 SGTC_1945 st075991 56.6 µM -1.00148698373212 0.18855959895765 no 2731 0.158295714913579 4100 1084980 SGTC_2958 9077254 16.72 µM -1.00513115269477 0.187698807466198 no 2732 0.157416850573014 4171 16457351 SGTC_2795 7780010 54.55 µM -1.00609900015042 0.187470600195812 no 2733 0.157183974808003 4093 953673 SGTC_1098 clofazimine 15.1 µM -1.00846029501251 0.18691455403237 no 2734 0.15661676983438 4154 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3015 9080845 49.47 µM -1.0098476037443 0.186588342036049 no 2735 0.156284154521159 4143 5296973 SGTC_1741 st038134 10.228 µM -1.00985361350851 0.186586929666451 no 2736 0.156282714658324 4170 1272587 SGTC_3025 9087895 49.47 µM -1.01094780321988 0.186329891760112 no 2737 0.156020706392865 4089 17173641 SGTC_2716 st080858 38.6235 µM -1.01115505337951 0.186281231006707 no 2738 0.155971112111315 4067 5296050 SGTC_3292 9120825 59.784 µM -1.01158223413142 0.186180957075409 no 2739 0.155868921947321 4107 24824900 SGTC_472 calcifediol 10 µM -1.01283392413723 0.185887335288033 no 2740 0.155569746915603 4143 5283731 A vitamin D metabolite. SGTC_703 3875-0075 71.8 µM -1.01302589063918 0.185842329144257 no 2741 0.155523897206416 4138 2850814 SGTC_3038 9091290 49.47 µM -1.01341250492413 0.185751708749111 no 2742 0.155431584443179 4137 25236843 SGTC_645 0845-0943 5.41 µM -1.01346976912728 0.185738288646198 no 2743 0.155417914415175 4102 1885106 SGTC_1265 0819-1001 68.8 µM -1.01675531805848 0.184969314136077 no 2744 0.15463492141068 4062 3106768 SGTC_480 am 92016 50 µM -1.01740925729365 0.184816497669676 no 2745 0.154479389999557 4087 2129 K+ channel blocker. SGTC_1170 0310-0127 64.8 µM -1.01859878333365 0.184538723316335 no 2746 0.154196741069616 4126 774975 SGTC_760 0568-0725 82.9 µM -1.01873822893403 0.18450617743294 no 2747 0.154163629151951 4137 3916171 SGTC_1779 st039427 55 µM -1.02160042910257 0.183838943540281 no 2748 0.153485027254459 4055 1124498 SGTC_1610 st001799 48.1 µM -1.0243121224786 0.183208183993018 no 2749 0.152843936973672 4037 621897 SGTC_2596 sinensetin 100 µM -1.02848508000512 0.182240164208454 no 2750 0.151860852782485 4147 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3246 9135460 32.98 µM -1.02871280257397 0.182187430517437 no 2751 0.151807326025434 4087 41446951 SGTC_2557 derrustone 83.84 µM -1.02904504855331 0.182110509462076 no 2752 0.151729253270968 4118 629853 An antioxidant. SGTC_381 3461-2219 42.7 µM -1.03008157389925 0.181870665274365 no 2753 0.151485857075769 4122 2883159 SGTC_1996 st072960 66.8 µM -1.03067570758551 0.181733276318108 no 2754 0.151346460107294 4158 1719405 SGTC_1496 4469-0713 57.4 µM -1.03266590514467 0.181273531289116 no 2755 0.150880137194615 4099 746691 SGTC_2862 9027634 71.43 µM -1.03363323838005 0.181050336021856 no 2756 0.150653827250439 4059 5012562 SGTC_2639 lactacystin 53 µM -1.0336514342332 0.181046139296709 no 2757 0.150649572453891 4177 3870 A proteasome inhibitor. SGTC_1182 1222-0449 220 µM -1.03402414558486 0.180960189873575 no 2758 0.150562437732454 4118 658318 SGTC_109 0132-0036 33.701 µM -1.03466843358496 0.180811673598943 no 2759 0.150411891357512 3934 67274 A color developer. SGTC_1788 fluconazole 20 µM -1.03526167933911 0.180674990773869 no 2760 0.150273360392859 4172 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2314 7727897 200 µM -1.03585586243344 0.180538156946342 no 2761 0.15013469580288 4145 900724 SGTC_1998 st075797 76.8 µM -1.03612416256353 0.180476391685848 no 2762 0.150072110526033 4119 24208315 SGTC_947 3447-0010 211 µM -1.03700815744782 0.180272981393359 no 2763 0.149866027723348 4081 748350 SGTC_2775 cyproheptadine 69.59 µM -1.03799770584431 0.180045453611406 no 2764 0.149635561577904 4133 2913 A selective serotonin reuptake inhibitor. SGTC_3268 9137683 49.47 µM -1.03923478839046 0.179761263791089 no 2765 0.149347777428324 4189 1953228 SGTC_2128 5255449 168.493 µM -1.04170329748459 0.179195026235972 no 2766 0.148774629862883 4097 736008 SGTC_1974 st069448 26.9 µM -1.04230275266913 0.179057690026504 no 2767 0.148635668277207 4116 6323587 YNR016C ACC1 SGTC_1625 st003711 30.1 µM -1.04247959171986 0.179017188549691 no 2768 0.148594691242119 4220 24207034 YER133W GLC7 SGTC_852 0418-0143 439 µM -1.04487664601235 0.178468759547653 no 2769 0.148039992386151 4149 5369229 SGTC_2624 nerol 100 µM -1.04686611045175 0.178014388836476 no 2770 0.147580667042835 4055 637566 A natural product oil. SGTC_603 3794-0023 45.9 µM -1.04774449839521 0.177814007492421 no 2771 0.147378169932872 4182 3802260 SGTC_1616 st002734 56.1 µM -1.04862921774967 0.177612325684118 no 2772 0.147174401522353 4089 4026101 SGTC_3023 9089636 49.47 µM -1.04886298066454 0.177559060896626 no 2773 0.147120592847645 4207 17249241 SGTC_1050 3232-1156 69.3 µM -1.04945198826207 0.177424895418849 no 2774 0.146985070732655 4131 700529 SGTC_898 1000-0849 28.3 µM -1.04950391208278 0.177413071164353 no 2775 0.146973127830488 4133 6751807 SGTC_515 4092-1064 102 µM -1.04995782155689 0.177309726666592 no 2776 0.146868752661395 4181 717353 SGTC_1721 st082152 9.2685 µM -1.05079244335897 0.177119802168445 no 2777 0.1466769635863 4074 5296051 SGTC_968 1309-0633 340 µM -1.05242716492533 0.176748181438502 no 2778 0.146301805439628 4195 3761976 SGTC_2870 9038528 12.99 µM -1.05310473560542 0.176594294115845 no 2779 0.146146496348433 4196 6463316 SGTC_2602 kawain 100 µM -1.05709865358397 0.175688932853258 no 2780 0.145233282821984 4151 5369129 SGTC_1786 berberine 21.6 µM -1.05772458252913 0.175547311178493 no 2781 0.1450905122911 4066 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2108 5365811 200 µM -1.05775500572951 0.175540429518444 no 2782 0.145083575354821 4159 780283 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.06175333518384 0.174637504342309 no 2783 0.14417383974892 4207 23847180 SGTC_662 k832-1615 104 µM -1.06192282866334 0.174599293641763 no 2784 0.144135360239842 4175 5878478 SGTC_3286 9117135 37.221 µM -1.06217420216539 0.174542633641468 no 2785 0.144078304548516 4131 3438150 SGTC_2153 5569715 200 µM -1.06303527416027 0.174348635120751 no 2786 0.143882977529471 4186 2054701 SGTC_2504 purpurogallin 52.29 µM -1.06323447259453 0.174303775463649 no 2787 0.14383781647573 4055 5281571 An antioxidant. SGTC_2208 7283366 200 µM -1.06332198161658 0.174284070676127 no 2788 0.143817979987734 4131 898663 SGTC_905 2-aminofluorene 215 µM -1.06347708223609 0.174249149472063 no 2789 0.143782826415229 4165 1539 An established DNA mutagen. YPR165W RHO1 SGTC_152 4469-0003 551.229 µM -1.06377375180665 0.174182366132547 no 2790 0.143715602375621 4064 697280 SGTC_1637 st007924 17.4 µM -1.06387908477944 0.174158658522121 no 2791 0.143691739482942 4079 683336 SGTC_2981 9013952 38.96 µM -1.0641788879104 0.174091192152155 no 2792 0.14362383455187 4123 2996344 SGTC_2125 5246583 200 µM -1.06532020505332 0.173834507226044 no 2793 0.143365526224517 4170 835267 SGTC_2686 alizarin 95.37 µM -1.06680399370913 0.173501159725612 no 2794 0.143030177393123 4151 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3160 9100216 49.47 µM -1.06717483383018 0.173417910486025 no 2795 0.142946447229346 4117 17191039 SGTC_842 0271-0008 11.1 µM -1.06921405518106 0.172960583752931 no 2796 0.142486613425219 4209 1221709 SGTC_1803 st050068 52.4 µM -1.06938416513036 0.172922468736993 no 2797 0.142448299777805 4217 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2991 9074669 71.4286 µM -1.06985647312499 0.172816670967447 no 2798 0.142341958985537 4157 17333109 SGTC_118 0083-0097 135.343 µM -1.07098915277217 0.172563116999306 no 2799 0.142087153500837 4174 5207356 SGTC_2767 sibutramine 71.45 µM -1.07184883044267 0.172370833826522 no 2800 0.141893968233893 4198 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.0747707767923 0.171718307488769 no 2801 0.141238683542274 4135 688761 SGTC_128 0906-2981 13.371 µM -1.07525184197795 0.171611027929845 no 2802 0.141130995387707 4159 6740226 SGTC_3063 1327-0034 4 µM -1.07638622574278 0.171358225161547 no 2803 0.140877280024232 4063 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_442 cape 100 µM -1.07995018147046 0.170565530604155 no 2804 0.140082182657079 4174 5281787 SGTC_2102 5377816 72.7585 µM -1.08053517474162 0.170435641150784 no 2805 0.139951965995299 4219 1379702 SGTC_774 k060-0086 136 µM -1.08201580124546 0.170107172205754 no 2806 0.139622753398691 4191 5911235 SGTC_902 1120-0002 2.07 µM -1.08202563774704 0.170104991388754 no 2807 0.139620568046141 4157 3280475 SGTC_634 1611-4317 11.2 µM -1.08206893797693 0.170095391656465 no 2808 0.13961094841189 4207 2843522 SGTC_3004 9076122 71.4286 µM -1.08285707901664 0.169920720166178 no 2809 0.139435932753383 4204 44782551 SGTC_129 0088-0017 176.636 µM -1.08724420580229 0.168950527290241 no 2810 0.138464449567033 4039 182446 SGTC_2635 hydroquinidine 100 µM -1.08909338656934 0.168542657630772 no 2811 0.138056353004246 4106 442912 An experimental heart treatment. SGTC_782 0083-0095 30.5 µM -1.08921993061902 0.168514769254422 no 2812 0.138028455957834 4168 3591729 An indicator and reagent. SGTC_3221 9128209 49.47 µM -1.0913735664652 0.168040595762061 no 2813 0.137554269418387 4207 16460723 SGTC_2166 5933061 31.504 µM -1.09152332466098 0.168007654940314 no 2814 0.137521337130293 4328 2877375 SGTC_1124 fisetin 1.16336 µM -1.09156116755466 0.16799933167296 no 2815 0.137513016213486 4198 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_45 0kpi-0036 14.9 µM -1.0917878819988 0.167949473048715 no 2816 0.137463173311269 4220 2795021 SGTC_2882 9058044 58.44 µM -1.09221777826353 0.167854957207276 no 2817 0.137368694998605 4222 18076804 SGTC_1540 guanosine 70.6 µM -1.09624478564438 0.1669712533883 no 2818 0.136485832608711 4073 6802 Guanosine is a purine nucleoside SGTC_1235 benzylparaben 21.5 µM -1.10030463798732 0.166083384954679 no 2819 0.135599706017114 4218 7180 SGTC_2107 5363541 170.161 µM -1.10525588886763 0.165004708662116 no 2820 0.13452436290942 4176 244052 SGTC_1701 st028638 40.4 µM -1.10732603271915 0.164555056277052 no 2821 0.134076496480093 4208 3490878 SGTC_1215 3852-0577 11.2 µM -1.1099220850152 0.163992295645715 no 2822 0.133516301388087 4246 2884876 SGTC_446 go6976 132 µM -1.11016417724354 0.163939879698067 no 2823 0.133464143138773 4228 3501 A protein kinase C inhibitor. SGTC_409 arachidonic acid 100 µM -1.11045202595948 0.163877571055927 no 2824 0.133402144993007 4186 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_495 decylubiquinone 155 µM -1.11087067447997 0.163786976508362 no 2825 0.13331200996423 4260 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1587 estradiol valerate 56.1 µM -1.1113971383995 0.163673097114639 no 2826 0.133198721766895 4250 13791 A steroid. SGTC_1358 1509-0022 2.48 µM -1.11550091655932 0.162787171531679 no 2827 0.13231791294828 4249 3258434 SGTC_2285 7945142 200 µM -1.11598597069406 0.162682664289612 no 2828 0.132214069936568 4258 2970608 SGTC_2607 solasodine 47.35 µM -1.11614291723513 0.162648858751109 no 2829 0.132180482006103 4186 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1451 4152-0210 104 µM -1.11686257288961 0.162493906869353 no 2830 0.132026544745273 4256 659563 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.11828417442011 0.162188098664083 no 2831 0.131722821861708 4188 6708739 YPR165W RHO1 SGTC_1373 2887-0003 58.5 µM -1.11893620942882 0.162047961410688 no 2832 0.13158367703001 4171 776948 SGTC_1129 3453-1384 223 µM -1.12456615550756 0.160841238418386 no 2833 0.130386461085721 4299 1084452 SGTC_2157 5649910 96.377 µM -1.12494253616965 0.160760774715426 no 2834 0.130306692773985 4205 2858091 SGTC_2118 5526350 200 µM -1.1261859907 0.160495132444199 no 2835 0.130043401026035 4260 743594 SGTC_1636 st007707 68.9 µM -1.12651400444626 0.16042510588384 no 2836 0.129974008107332 4251 403051 SGTC_1525 8-methoxypsoralen 92.5 µM -1.12817715352152 0.160070353016923 no 2837 0.129622555248376 4274 4114 Related to psoralen; DNA damaging agent. SGTC_2222 6885208 172.143 µM -1.13027742681248 0.159623094157892 no 2838 0.12917967158054 4189 609514 SGTC_1862 st057513 3.81 µM -1.13078631383082 0.159514848501346 no 2839 0.129072520871528 4205 5393163 SGTC_1896 st058441 89 µM -1.133466220827 0.158945596886484 no 2840 0.128509259381572 4233 688759 SGTC_419 nsc-638432 893 µM -1.13404554679636 0.158822714748355 no 2841 0.128387721551286 4175 368090 SGTC_433 pimozide 108 µM -1.1340478798665 0.158822220001509 no 2842 0.128387232253717 4129 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1202 1988-0068 29.6 µM -1.13502026649253 0.158616105314765 no 2843 0.12818341349011 4197 2850480 SGTC_1523 st012844 44.7 µM -1.13836089902044 0.157909335661702 no 2844 0.127484907112009 4312 4274103 SGTC_2650 prasterone 100 µM -1.13838601138184 0.15790403054236 no 2845 0.12747966630961 4218 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1112 tnp00069 1.16933 µM -1.13867145203531 0.157843737918153 no 2846 0.127420107050399 4244 145826 SGTC_1654 st012436 41.8 µM -1.13872194287888 0.157833074488938 no 2847 0.127409573784952 4232 4323132 SGTC_2871 9038510 12.99 µM -1.13902353324114 0.157769389872862 no 2848 0.127346669417797 4207 4945164 SGTC_2201 6605497 169.863 µM -1.14083102525212 0.157388068831049 no 2849 0.126970123522126 4163 670741 SGTC_2757 clomiphene 4.22 µM -1.1428038595878 0.156972558057198 no 2850 0.126560017992075 4263 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2636 apigenin dimethyl ether 100 µM -1.14307777302779 0.156914924566916 no 2851 0.126503150903991 4227 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2016 5121758 140 µM -1.14340331879091 0.156846445347375 no 2852 0.126435587596958 4157 2795203 SGTC_817 1391-0715 46 µM -1.14470417276312 0.156573004356209 no 2853 0.126165861164713 4217 1353946 SGTC_1508 1080-0625 72.9 µM -1.14492407359498 0.156526811979551 no 2854 0.126120305341417 4143 767111 SGTC_1390 3413-2614 145 µM -1.1466710384324 0.156160163298335 no 2855 0.125758802222447 4259 3421432 SGTC_2146 5545642 200 µM -1.14732297550591 0.1560234814579 no 2856 0.125624080888827 4201 825326 SGTC_2184 6075246 200 µM -1.14927263430727 0.155615196431394 no 2857 0.12522178926603 4242 2267320 SGTC_1964 st076914 61 µM -1.14969968090627 0.155525861243039 no 2858 0.125133792910924 4281 24208661 SGTC_1522 st012842 45.6 µM -1.15303396553589 0.154829515543816 no 2859 0.124448221773369 4094 3491067 YOR116C RPO31 SGTC_226 1,3-diallylurea 8.28947 mM -1.15310088792888 0.154815560313002 no 2860 0.124434488620101 4172 74537 YKL182W FAS1 SGTC_1277 0873-0036 22 µM -1.15397394660301 0.154633578769324 no 2861 0.124255425216331 4314 5965735 SGTC_661 1304-0007 33.6 µM -1.15431376257006 0.15456278529932 no 2862 0.124185778075591 4246 3117130 SGTC_1506 4226-2149 212 µM -1.15652442806458 0.15410276292969 no 2863 0.123733356800628 4259 991114 SGTC_2226 7298446 200 µM -1.15839139093576 0.15371496858036 no 2864 0.123352175404764 4244 3283010 SGTC_960 1222-0186 7.7 µM -1.15863597033436 0.153664213915017 no 2865 0.123302300174682 4260 3126296 SGTC_1821 st053465 65.6 µM -1.1599679562356 0.15338799743579 no 2866 0.123030926366185 4257 675086 SGTC_1775 st081588 35.1725 µM -1.16537061149831 0.152271012899046 no 2867 0.121934503971531 4262 1426443 YGL099W LSG1 SGTC_993 3909-8757 62.7 µM -1.16580243945195 0.152181967267865 no 2868 0.121847165351423 4204 4288324 YLR208W SEC13 SGTC_2452 5863136 48.41 µM -1.16916979083818 0.151488784504981 no 2869 0.121167614885992 4217 2184096 SGTC_2210 7115885 190.385 µM -1.17042736172057 0.151230447743605 no 2870 0.120914514952536 4355 2927039 SGTC_1066 ketoconazole 628 nM -1.17059685275724 0.151195652435198 no 2871 0.120880431492795 4328 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.17144354298216 0.151021912693963 no 2872 0.120710269272064 4289 6708561 SGTC_2408 sulbentine 18.36 µM -1.17497179428262 0.15029935090421 no 2873 0.120003000190295 4168 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_3253 9135987 49.47 µM -1.17642847685815 0.15000170527518 no 2874 0.119711848903789 4260 4182430 SGTC_895 0964-0006 13.7 µM -1.18569423193701 0.148117628375038 no 2875 0.117871536627784 4255 6738897 SGTC_1929 genistein trimethyl ether 50.5 µM -1.186007299688 0.148054247701111 no 2876 0.11780970839675 4244 136420 SGTC_2002 4023503 131 µM -1.18622937675342 0.14800929912891 no 2877 0.117765863971667 4273 4736863 YCR052W RSC6 SGTC_1029 k015-0030 64.7 µM -1.18727451891932 0.147797884185215 no 2878 0.117559677782475 4306 2208316 SGTC_1216 1165-0504 9.65 µM -1.1886253667834 0.147524929755304 no 2879 0.117293560616214 4283 6304004 SGTC_1031 k035-0009 16 µM -1.19102744820846 0.147040396098684 no 2880 0.116821404810641 4331 5180959 SGTC_341 1486-1430 230 µM -1.19410761150175 0.146420646948428 no 2881 0.116217938105787 4232 2054753 YPL210C SRP72 SGTC_969 1313-0238 134 µM -1.19438105311732 0.146365713568509 no 2882 0.116164472432179 4313 5212874 SGTC_1 0258-0098 57.368 µM -1.19596079024915 0.146048621311208 no 2883 0.115855930275271 4231 6790032 YDR047W HEM12 SGTC_812 4251-0442 148 µM -1.20001945476425 0.14523606449327 no 2884 0.115065892421887 4310 5723007 SGTC_2482 5981709 142.65 µM -1.20289524067587 0.144662168167696 no 2885 0.114508431159248 4208 877755 SGTC_3170 9103054 49.47 µM -1.20341936312423 0.144557738266612 no 2886 0.114407039273833 4261 16432970 SGTC_463 ikarugamyin 104 µM -1.20471794519754 0.144299218351264 no 2887 0.11415610298645 4432 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1827 berberine 7.24 µM -1.20644098266773 0.143956679783879 no 2888 0.113823751007691 4203 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2417 cerulenin 830 nM -1.20949201034856 0.143351484099499 no 2889 0.113236939372699 4311 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1507 4075-3230 155 µM -1.20974225266876 0.143301922884617 no 2890 0.113188905598397 4239 659771 SGTC_1131 3454-3128 32.3 µM -1.2099978814464 0.143251306815424 no 2891 0.11313985291052 4315 710982 SGTC_3059 1327-0034 3 µM -1.21112798369892 0.143027684319718 no 2892 0.112923178983871 4151 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1796 st049173 110.4 µM -1.21208423096943 0.142838648242234 no 2893 0.112740069666765 4259 94134 SGTC_1618 st003135 44.5 µM -1.21267119472643 0.142722697784613 no 2894 0.112627778557467 4269 1270615 SGTC_2947 9072639 7.68 µM -1.21650344340821 0.141967228872834 no 2895 0.111896600059768 4291 16488146 SGTC_2374 9071832 200 µM -1.21665744631766 0.141936926256491 no 2896 0.11186728800161 4225 17381698 SGTC_1181 1222-0449 220 µM -1.21784510370926 0.141703382160246 no 2897 0.111641420346864 4361 658318 SGTC_2049 5262831 67.185 µM -1.21803854620691 0.141665367779341 no 2898 0.111604662540485 4280 763417 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.2183024923356 0.141613509511599 no 2899 0.111554521653361 4223 5355888 SGTC_1703 st026983 48.3 µM -1.21984228135562 0.141311239027007 no 2900 0.11126233481394 4327 1104023 SGTC_2537 larixol 68.93 µM -1.22114700561939 0.141055455795149 no 2901 0.111015182471026 4278 6708759 SGTC_1204 4049-0315 18.3 µM -1.22144907882731 0.14099628097632 no 2902 0.110958017208637 4353 588402 SGTC_1333 1482-0047 286 µM -1.22261108447883 0.140768806133732 no 2903 0.11073831225304 4311 3811116 SGTC_734 2023-0417 80 µM -1.22273632954955 0.140744302967263 no 2904 0.110714650301121 4312 3935732 SGTC_889 0919-1524 82.7 µM -1.22285498451134 0.140721091771285 no 2905 0.110692236729343 4315 3905452 SGTC_83 0170-0301 39.027 µM -1.22312054046358 0.14066915332495 no 2906 0.110642085777404 4306 3089716 SGTC_159 3970-0959 50 µM -1.2247805598267 0.140344775275303 no 2907 0.110328955728738 4366 6615653 SGTC_1553 gossypol 38.6 µM -1.22614175649349 0.140079168341914 no 2908 0.110072667302735 4189 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_706 4262-0057 46.9 µM -1.22642566088806 0.140023813852872 no 2909 0.110019267174677 4304 883298 SGTC_1886 st057356 49.9 µM -1.22994485582688 0.139338889960736 no 2910 0.109358877718165 4296 24207747 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.23180290252809 0.138978188260133 no 2911 0.109011359412453 4327 2374 Ca(2+)-ATPase inhibitor. SGTC_1963 st076565 50.3 µM -1.23607348866002 0.138151552857946 no 2912 0.108215624191998 4334 4914280 SGTC_2078 5212016 200 µM -1.23707796004013 0.137957610511718 no 2913 0.108029070625032 4206 1899708 SGTC_3029 9088683 49.47 µM -1.2391082398834 0.137566173346139 no 2914 0.107652707960223 4346 25236615 SGTC_1875 nocodazole 6 µM -1.24053268332691 0.137291994174972 no 2915 0.107389216601253 4343 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_484 loperamide 105 µM -1.24306435445386 0.136805615660172 no 2916 0.106922059914554 4389 3955 An opioid-receptor agonist. SGTC_2964 9083345 53.42 µM -1.24659467002347 0.136129348501828 no 2917 0.106273078527186 4297 17741579 SGTC_57 miconazole 162.5 nM -1.24814139977328 0.135833779022533 no 2918 0.105989639746927 4186 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_156 3474-0145 5.642 µM -1.25420738353871 0.134678854302476 no 2919 0.104883318424537 4246 2265471 SGTC_380 3970-0968 6 µM -1.2562412424908 0.134293133439495 no 2920 0.104514258969019 4203 2891601 SGTC_676 falcarinol 140 µM -1.25631720780932 0.134278741347357 no 2921 0.104500492723458 4364 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3080 9117754 49.47 µM -1.25833087258092 0.133897626457981 no 2922 0.104136060239799 4329 9550191 SGTC_3326 9140064 16.379 µM -1.25867681122683 0.133832227517323 no 2923 0.104073545213725 4274 1868434 SGTC_1837 st055472 66.5 µM -1.25997889702421 0.133586267919594 no 2924 0.103838487540197 4393 676091 SGTC_260 nsc-65238 3.989 µM -1.26012692251659 0.133558326095356 no 2925 0.103811789789871 4331 3246252 SGTC_2297 7971671 152.32 µM -1.26401963318352 0.132824966407996 no 2926 0.103111490090588 4340 909016 SGTC_2321 7390090 138.78 µM -1.26452388921051 0.132730171328578 no 2927 0.103021025902632 4356 649046 SGTC_846 0335-0850 148 µM -1.26834139780138 0.132014029656326 no 2928 0.102338029699343 4321 6819598 SGTC_2003 4023581 200 µM -1.26939332936176 0.13181716279424 no 2929 0.102150407073479 4354 16641307 SGTC_709 3807-1509 243 µM -1.26953689329125 0.131790310810787 no 2930 0.102124820414794 4406 1886677 YPL242C IQG1 SGTC_103 0844-0104 51.839 µM -1.27024535379722 0.131657856677623 no 2931 0.101998623429538 4189 5375804 SGTC_2163 5671233 125 µM -1.27106758815028 0.131504246544743 no 2932 0.101852302405019 4317 701023 SGTC_122 0236-0016 402.397 µM -1.27114551205815 0.131489695191351 no 2933 0.101838443356438 4335 6808838 SGTC_3225 9130819 49.47 µM -1.27388714171342 0.130978436202834 no 2934 0.101351708006087 4299 4547121 SGTC_1864 st057645 30.4 µM -1.27483133536318 0.130802681402695 no 2935 0.101184473502905 4385 688666 SGTC_150 3970-0969 77.2 µM -1.27539345851699 0.130698123699339 no 2936 0.10108500643402 4409 6615640 SGTC_69 0096-0274 206.684 µM -1.27635098500867 0.130520152073816 no 2937 0.100915737306998 4458 6741392 SGTC_2388 9080168 200 µM -1.27719290924626 0.130363805498672 no 2938 0.100767074869742 4361 15943073 SGTC_273 hydroxyurea 18.1 mM -1.27817010357561 0.130182501570799 no 2939 0.100594727503315 4405 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1828 st055811 49 µM -1.28117645041432 0.129625812880836 no 2940 0.100065847904347 4358 5877589 SGTC_1383 3049-0032 20.7 µM -1.28243260625746 0.129393698193264 no 2941 0.0998454661029863 4415 712864 SGTC_648 0375-0473 33.3 µM -1.28285296552017 0.129316087826539 no 2942 0.0997717968922966 4326 1713139 SGTC_115 0527-0192 112.043 µM -1.28321170268599 0.129249880184677 no 2943 0.0997089585472665 4340 4233931 SGTC_1624 st003710 6.25 µM -1.28475854329732 0.12896466821406 no 2944 0.0994383367002666 4390 24207033 SGTC_1137 ixabepilone 100 µM -1.28526455534829 0.128871462729092 no 2945 0.0993499258574921 4309 154225 A novel microtubule stabilizer. SGTC_348 k064-0012 10.7 µM -1.28711938814034 0.128530209207996 no 2946 0.0990263393470479 4279 5066323 SGTC_1393 3470-5649 58.2 µM -1.29036414150565 0.127934746369666 no 2947 0.0984621281127783 4337 4108395 SGTC_2090 5301565 104.445 µM -1.29160079451763 0.127708306524187 no 2948 0.0982477143823634 4353 2056344 SGTC_1800 st050079 29.0735 µM -1.29163581196405 0.127701898642532 no 2949 0.0982416479604987 4186 3645560 SGTC_1807 st050092 58.9 µM -1.29208154524156 0.12762035293959 no 2950 0.0981644531070036 4373 5008496 SGTC_2652 actinonin 100 µM -1.29244571721871 0.127553755533139 no 2951 0.0981014165363233 4399 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_966 1300-0360 30.2 µM -1.29306971388446 0.127439699256303 no 2952 0.0979934744066538 4363 70588 SGTC_2919 7978188 46.38 µM -1.29351746118183 0.12735790216853 no 2953 0.0979160744418741 4382 2980291 SGTC_2628 lathosterol 100 µM -1.29700582376289 0.126721878207661 no 2954 0.0973145914975361 4411 6710616 SGTC_2387 9077560 195.08 µM -1.29925952310054 0.126312145123502 no 2955 0.0969274401528952 4376 5303272 SGTC_1223 0764-0573 147 µM -1.30151296308577 0.125903383143271 no 2956 0.0965414651406077 4365 1609797 SGTC_1468 k284-1086 134 µM -1.3021054640608 0.125796059965673 no 2957 0.0964401677774079 4365 15996457 SGTC_1590 st077108 57.8 µM -1.30267920986606 0.125692194852167 no 2958 0.0963421513563034 4385 5489485 SGTC_2104 5389443 200 µM -1.30580062765167 0.125128173279403 no 2959 0.0958101832885052 4400 2244536 SGTC_1946 st076057 65.1 µM -1.30694020958079 0.124922698732128 no 2960 0.0956165092726657 4327 953009 SGTC_789 1309-1135 70.6 µM -1.30776386540848 0.124774334692273 no 2961 0.0954767069324105 4326 3092424 SGTC_843 0310-0051 143 µM -1.30960828740131 0.12444254810224 no 2962 0.0951641917133776 4397 2065037 SGTC_12 0849-0099 9.267 µM -1.31025516423581 0.124326329953309 no 2963 0.0950547648043942 4300 6071388 SGTC_382 3229-0966 23.2 µM -1.31175750609624 0.124056711543524 no 2964 0.094800983436794 4416 5722370 SGTC_2671 danthron 100 µM -1.31621961313197 0.123258330739921 no 2965 0.0940501713034435 4366 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3109 9122853 49.47 µM -1.31755067622333 0.123020869512886 no 2966 0.0938270531432199 4409 1234709 SGTC_629 3448-6466 76.7 µM -1.31809651685102 0.12292358450287 no 2967 0.0937356701855252 4387 573744 SGTC_3352 9151559 45.5865 µM -1.32065266592631 0.12246872064631 no 2968 0.0933086018017658 4393 17159339 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.32066292240475 0.122466897899781 no 2969 0.0933068911019931 4387 7104 SGTC_1591 genipin 88.4 µM -1.32349618944612 0.121964108098201 no 2970 0.0928352113342198 4408 442424 A DNA cross-linking agent. SGTC_1035 k081-0041 55.2 µM -1.32479574632763 0.121733975218991 no 2971 0.0926194530184765 4396 731709 SGTC_53 0973-0023 39.979 µM -1.32483041838566 0.121727839476626 no 2972 0.0926137016907694 4272 674768 SGTC_3219 9131112 49.47 µM -1.3284463252044 0.121089143041351 no 2973 0.092015352120947 4251 17612988 YMR079W SEC14 SGTC_397 arbidol 50 µM -1.32976543124657 0.120856730396631 no 2974 0.091797784468048 4419 131410 A RNA synthesis inhibitor. SGTC_4 0960-0234 25.671 µM -1.32982600376651 0.120846065698179 no 2975 0.0917878030570229 4389 6821112 SGTC_339 3091-4833 71.4 µM -1.33276070737277 0.120330160409247 no 2976 0.0913051720090686 4227 3240077 SGTC_1650 st011916 45.8 µM -1.33644063430922 0.119685443903607 no 2977 0.0907026461349755 4332 242528 SGTC_417 st075190 100 µM -1.33677341941741 0.1196272609017 no 2978 0.0906483040344104 4379 222757 SGTC_461 N-acetylfarnesylcysteine 136 µM -1.33834446464503 0.119352854172434 no 2979 0.0903920867086376 4450 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2891 9063876 19.48 µM -1.33874518229684 0.119282933946692 no 2980 0.0903268209571629 4417 6472478 SGTC_689 0833-0039 98 µM -1.3394773358008 0.119155256977156 no 2981 0.0902076639276113 4344 5374726 SGTC_1246 0422-0085 105 µM -1.3411058781495 0.118871608795819 no 2982 0.0899430395472073 4409 264295 SGTC_2794 7785382 27.27 µM -1.34423880528426 0.118327279249231 no 2983 0.0894355884633199 4392 2205081 SGTC_2718 lomofungin 53.02 µM -1.34507740295943 0.118181876768913 no 2984 0.0893001198680215 4374 5351222 A RNA synthesis inhibitor. SGTC_1953 st076800 12.1 µM -1.34753955287008 0.117755700588487 no 2985 0.0889032618387429 4392 297591 SGTC_3021 9087658 49.47 µM -1.34872136235663 0.117551526675296 no 2986 0.0887132406368054 4403 25237042 SGTC_3299 9121982 43.1275 µM -1.34969059758541 0.117384265056953 no 2987 0.0885576247903859 4418 17594604 YPL160W CDC60 SGTC_1630 st005209 31.3 µM -1.34991212287382 0.117346059952897 no 2988 0.0885220862993269 4393 3367314 SGTC_1783 st039459 87.517 µM -1.35066164565078 0.117216859676409 no 2989 0.088401921893008 4473 729761 SGTC_51 1013-0126 23.419 µM -1.3507518659623 0.117201314592534 no 2990 0.0883874658622368 4409 1627850 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.35533187371397 0.116414090968206 no 2991 0.0876559221236341 4314 17037758 SGTC_1434 4073-0095 163 µM -1.35705550213966 0.116118802876565 no 2992 0.0873817879123274 4400 24133745 SGTC_1764 st044502 93.5 µM -1.35960125023065 0.115683644187322 no 2993 0.0869780711545829 4427 8407 SGTC_1120 ficusin 1.78878 µM -1.36252753466731 0.115184870852291 no 2994 0.0865157302916078 4428 6199 A DNA cross-linker. SGTC_1203 3992-3522 103 µM -1.36307863849558 0.115091108770499 no 2995 0.0864288641285328 4491 5322312 SGTC_2432 5630864 12.22 µM -1.36363426767234 0.114996631722311 no 2996 0.0863413507051035 4410 5714970 SGTC_1940 st075990 51.1 µM -1.36416901592867 0.114905757283576 no 2997 0.0862571886876756 4463 1084979 SGTC_1993 st073995 70.8 µM -1.36645298523955 0.114518197458508 no 2998 0.0858984139483222 4413 3098394 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.36709507489895 0.114409410958451 no 2999 0.0857977534142136 4404 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_393 acivicin 6.25 µM -1.3671831827627 0.114394488962917 no 3000 0.0857839476174877 4271 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.37005680628251 0.113908569870967 no 3001 0.0853345848596915 4399 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.37217207002299 0.113551827608382 no 3002 0.0850049389711507 4459 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1771 st048882 4.1505 µM -1.37412871790411 0.11322254604175 no 3003 0.084700862679544 4445 4580403 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.3748481889046 0.113101638726966 no 3004 0.084589257389334 4426 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3346 9158254 43.5805 µM -1.37618494860897 0.112877240536386 no 3005 0.0843821903812933 4443 17639500 SGTC_618 k072-0232 33.2 µM -1.3766680420928 0.11279622319217 no 3006 0.0843074517799563 4457 5872756 YGL099W LSG1 SGTC_217 ketoconazole 989 nM -1.37710954290232 0.112722217477481 no 3007 0.0842391913696612 4231 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2430 5571206 200 µM -1.3792378404552 0.112365952156133 no 3008 0.0839107172857904 4400 1731771 SGTC_3302 9125395 16.351 µM -1.38041949316665 0.11216849768156 no 3009 0.0837287608517593 4370 17599668 SGTC_539 4859-0462 2.54 µM -1.38115376615441 0.1120459254802 no 3010 0.0836158434598598 4454 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1785 bathophenanthroline 24 µM -1.383122091969 0.111717825294605 no 3011 0.083313716415267 4348 72812 An iron chelator. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.38847774877635 0.110828571582257 no 3012 0.0824958079042335 4427 688798 SGTC_1456 k015-0012 13 µM -1.38903080731876 0.11073703140199 no 3013 0.0824116911205323 4447 2989616 SGTC_1118 chelidonine 707.474 nM -1.39113607912186 0.110389070372976 no 3014 0.0820920830358537 4412 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_564 3555-0129 330 µM -1.39350932706847 0.109997758843467 no 3015 0.0817329132672283 4332 563260 SGTC_2568 diosmetin 100 µM -1.39373109345804 0.109961243940306 no 3016 0.0816994115280887 4441 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_741 4582-0002 126 µM -1.39392274499748 0.109929694599239 no 3017 0.0816704675100417 4445 2912688 SGTC_1691 st019933 84.6 µM -1.39496439193284 0.109758334096017 no 3018 0.0815132888048047 4410 6176082 SGTC_1212 0520-0165 585 µM -1.39728180526659 0.10937778629693 no 3019 0.0811644225145667 4504 5403258 SGTC_2993 9054257 71.4286 µM -1.39737168924896 0.109363045356853 no 3020 0.0811509139999118 4366 6470217 YGL055W OLE1 SGTC_1612 st002233 45.4 µM -1.3999935328102 0.108933691717835 no 3021 0.0807576275540925 4449 1035021 SGTC_252 miconazole 1.30953 nM -1.4010778547996 0.108756477584293 no 3022 0.0805953965006094 4335 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2625 euphol 100 µM -1.40346992132331 0.108366268006476 no 3023 0.0802383776460678 4435 6708538 A triterpene alcohol. SGTC_2777 climbazole 1.536 µM -1.40603185653147 0.107949466741847 no 3024 0.0798573326776174 4264 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_488 nitrendipine 139 µM -1.40788616365349 0.107648510507506 no 3025 0.0795823904029788 4463 4507 Dihydropyridine L-type calcium channel blocker. SGTC_212 3807-4682 38.772 µM -1.40862370814052 0.107528974366027 no 3026 0.079473232343958 4511 3125501 YBL034C STU1 SGTC_1819 st053448 58.6 µM -1.41237009923512 0.106923261941426 no 3027 0.0789205079086715 4367 2857616 SGTC_2301 7769476 200 µM -1.41440071158376 0.106595985249312 no 3028 0.0786221406431808 4428 977820 SGTC_1938 st074717 56.4 µM -1.41528118118994 0.10645430367065 no 3029 0.0784930352004643 4312 17250979 SGTC_3232 9132874 49.47 µM -1.41880291240107 0.105888960646017 no 3030 0.0779782416869935 4414 3784940 SGTC_565 1418-0001 44.5 µM -1.41996523263979 0.105702850648863 no 3031 0.0778089015320169 4486 2862145 SGTC_1305 1181-0477 144 µM -1.42237616499007 0.105317567905645 no 3032 0.0774585393394947 4504 6252086 SGTC_2227 7312221 64.1025 µM -1.42457846506306 0.104966514794361 no 3033 0.0771395443416507 4566 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_633 0437-0093 97.7 µM -1.42999631794415 0.104106500126191 no 3034 0.0763590379299 4377 2831118 SGTC_1422 4031-0024 15.5 µM -1.43412922233886 0.103453897770889 no 3035 0.0757676950560903 4401 782427 SGTC_1851 st056236 18.9 µM -1.43461592827109 0.103377240794051 no 3036 0.0756982865628998 4442 5393171 SGTC_3300 9124615 50.48 µM -1.4361504051124 0.103135828140404 no 3037 0.0754797739068806 4483 24824903 SGTC_3161 9100388 49.47 µM -1.43769353162364 0.102893467827496 no 3038 0.0752605146085031 4528 25236368 SGTC_2909 7941780 10.49 µM -1.438560494779 0.102757486032528 no 3039 0.0751375430217871 4417 1243215 SGTC_2914 7968218 45.32 µM -1.43902841731913 0.102684147413257 no 3040 0.0750712357545338 4415 2977111 SGTC_2675 theaflavin digallate 100 µM -1.44167276114697 0.102270407975952 no 3041 0.0746973556749241 4391 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1313 1220-0047 237 µM -1.44470145691848 0.101798023287759 no 3042 0.0742708802554298 4448 3528706 SGTC_1749 st037932 54.2 µM -1.44543484990957 0.101683875472004 no 3043 0.0741678902235123 4475 594497 SGTC_3151 9099821 49.47 µM -1.44796523022569 0.101290753837628 no 3044 0.073813387457538 4402 17174189 SGTC_1847 st056231 15 µM -1.44817657841613 0.10125796881382 no 3045 0.07378383657049 4453 5393180 SGTC_379 3970-0972 5.9 µM -1.44907079918951 0.101119339920774 no 3046 0.0736589059056297 4460 2898042 YBL034C STU1 SGTC_2541 muurolladie-3-one 83.07 µM -1.4501259160012 0.100955945657428 no 3047 0.0735117046729458 4420 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2942 9052777 62.25 µM -1.45023208556093 0.100939515017062 no 3048 0.0734969052330337 4481 6469503 SGTC_2788 5282734 71.43 µM -1.45252130889689 0.10058571235009 no 3049 0.0731783542819586 4492 743706 SGTC_651 3253-0966 34.4 µM -1.46420159944758 0.0987945845977541 no 3050 0.0715694366740587 4489 781462 SGTC_628 1636-0253 16 µM -1.46980871288366 0.0979430940926047 no 3051 0.07080678436433 4471 4456143 SGTC_589 1227-0070 34.1 µM -1.47175478042421 0.0976488271461549 no 3052 0.0705435543716994 4525 2841384 SGTC_2341 7987486 176.74 µM -1.47191277981006 0.0976249643740738 no 3053 0.0705222160355155 4493 1258686 SGTC_473 2-arachidonoylglycerol 10 µM -1.47384975142977 0.0973327694843483 no 3054 0.0702610247457316 4317 5282280 An endocannabinoid. SGTC_3193 9111931 49.47 µM -1.47477580664015 0.0971932996737742 no 3055 0.0701364138212627 4477 17087244 SGTC_1065 prochlorperazine maleate 2.48 µM -1.48147240066949 0.0961891124034566 no 3056 0.0692403670872679 4515 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_309 k408-0051 1.48 µM -1.48557177963897 0.095578165668876 no 3057 0.0686962120604647 4412 3640463 SGTC_2464 5717415 7.67 µM -1.48573536120957 0.0955538458423408 no 3058 0.0686745667251759 4448 5285744 SGTC_130 0136-0219 337.655 µM -1.48726583931971 0.0953265288079285 no 3059 0.0684723065178687 4368 234244 SGTC_3009 9080819 71.4286 µM -1.48797242351696 0.0952217165436443 no 3060 0.0683790831403367 4495 17027216 SGTC_1073 triclabendazole 3.09 µM -1.49462849207163 0.094238540281298 no 3061 0.067505712975539 4529 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2761 levamisole 97.89 µM -1.49674351341626 0.0939277009199979 no 3062 0.0672300046345525 4498 26879 An alkaline phosphatase inhibitor. SGTC_1962 st076595 64.5 µM -1.49972964150131 0.0934901264474253 no 3063 0.0668422245523013 4458 279619 SGTC_2529 gangaleoidin 93.61 µM -1.50166381898356 0.0932075048751987 no 3064 0.0665919762172058 4485 4565183 SGTC_695 3505-6186 243 µM -1.50236574652787 0.0931050956674049 no 3065 0.0665013387680046 4491 1819379 SGTC_1195 1502-0147 41.1 µM -1.50337490836006 0.0929580076201822 no 3066 0.066371196619145 4503 817940 SGTC_75 0159-0059 199.013 µM -1.50634991323646 0.0925253924146776 no 3067 0.065988685603264 4550 5377270 SGTC_3048 9093155 49.47 µM -1.50653409201857 0.0924986587986033 no 3068 0.0659650610953825 4469 25236002 SGTC_1140 3229-1848 2.98 µM -1.51037118729587 0.0919430020888713 no 3069 0.0654743681887788 4489 2849525 SGTC_2563 tomatine 8.54 µM -1.51211725501162 0.0916909707966588 no 3070 0.0652520179922325 4450 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1086 cerivastatin 2.18 µM -1.51219575705294 0.091679651673171 no 3071 0.0652420350541275 4520 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_3266 9136860 49.47 µM -1.51814538410394 0.0908247911586377 no 3072 0.0644888761263445 4265 4871271 YPR165W RHO1 SGTC_2181 6316240 54.2555 µM -1.51963420535633 0.09061180094647 no 3073 0.0643014680504475 4517 12779990 SGTC_1766 st045414 44.774 µM -1.51992925214262 0.0905696357163221 no 3074 0.0642643788007746 4515 253960 SGTC_1064 honokiol 6.76 µM -1.52200196360172 0.090273834357652 no 3075 0.0640042943407644 4534 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3192 9110362 49.47 µM -1.52909579178389 0.0892668881222342 no 3076 0.0631203492240151 4509 16649480 SGTC_3285 9112818 20.8695 µM -1.5295061992725 0.089208888845807 no 3077 0.063069501709146 4490 17017947 YPR165W RHO1 SGTC_483 fpl-64176 144 µM -1.53014438361899 0.089118755581359 no 3078 0.0629904971181765 4637 3423 SGTC_2493 resveratrol 26.09 µM -1.53335674126663 0.0886660907369631 no 3079 0.0625939905647704 4467 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1157 4092-0394 27.6 µM -1.53341547611132 0.0886578301704885 no 3080 0.062586758980441 4561 3659885 SGTC_1474 0330-0125 5.35 µM -1.53403093295649 0.0885713057630794 no 3081 0.0625110215206177 4573 X1474 SGTC_2714 st079313 56.9 µM -1.53576852959113 0.0883273640968334 no 3082 0.0622975803520174 4504 2939799 SGTC_1222 0366-0074 1.18 µM -1.53725427310502 0.0881191775506747 no 3083 0.0621155272238622 4527 286520 SGTC_1427 4048-4900 550 nM -1.53861741394319 0.087928492414846 no 3084 0.0619488623589776 4495 24132586 SGTC_3081 9117243 49.47 µM -1.54151536864893 0.087524130157474 no 3085 0.0615957027180511 4480 45595589 SGTC_1378 2093-0007 380 nM -1.5431768325164 0.0872929267671812 no 3086 0.0613939384110735 4537 3618014 SGTC_655 k060-0012 42 µM -1.54935053334934 0.08643781095648 no 3087 0.0606487390844612 4509 5994525 SGTC_1567 st069303 68.4 µM -1.55100680666031 0.0862094705249071 no 3088 0.0604500263896451 4527 5581319 SGTC_1302 1159-0335 255 µM -1.55412292443469 0.0857810935602071 no 3089 0.0600775489730026 4545 649284 SGTC_3 0833-0587 95.581 µM -1.55788585829968 0.0852659240841618 no 3090 0.0596301540560711 4413 5382644 SGTC_2762 leflunomide 42.06 µM -1.55881304914679 0.0851393424560444 no 3091 0.0595203173877995 4500 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1023 4482-3888 16 µM -1.55935925353826 0.0850648396711774 no 3092 0.0594556873089052 4535 3303168 SGTC_924 2046-0044 21.3 µM -1.55954908318361 0.0850389581767211 no 3093 0.0594332384477718 4507 3623589 SGTC_52 0329-0193 875 nM -1.55989040289602 0.0849924372774295 no 3094 0.0593928913991967 4555 3739292 SGTC_2173 5763948 167 µM -1.5635107554313 0.084500167291178 no 3095 0.0589662539494904 4493 2867177 SGTC_2674 ligustilide 100 µM -1.56409114586297 0.0844214492393131 no 3096 0.058898082502212 4573 5319022 A signalling regulator. SGTC_2685 mycophenolic acid 18.85 µM -1.5690492332969 0.0837512277496106 no 3097 0.0583182337925213 4531 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2581 avocatin a 64 µM -1.56984159337938 0.0836444900048337 no 3098 0.0582259841885015 4464 6710728 A skin care supplement. SGTC_1193 1488-0126 41.5 µM -1.5769898111918 0.0826861791992319 no 3099 0.0573989347531264 4512 1384710 SGTC_650 1328-0195 38 µM -1.57725540884671 0.0826507322823847 no 3100 0.0573683840959824 4544 2780821 SGTC_2395 5646831 180.19 µM -1.57805815043643 0.0825436671421839 no 3101 0.0572761256433958 4510 6808628 SGTC_1477 0139-0234 16 µM -1.57983963185449 0.0823064361959622 no 3102 0.057071798486755 4552 620880 SGTC_375 3970-0961 9.27 µM -1.58127935915068 0.0821150903702681 no 3103 0.0569070884732543 4506 2898222 SGTC_2355 9061122 103.12 µM -1.58129391986794 0.0821131569027316 no 3104 0.0569054245885479 4546 5302957 SGTC_570 0987-0065 62.6 µM -1.58415191728561 0.0817343168927504 no 3105 0.0565795760996151 4407 3104428 SGTC_2893 9048488 25.97 µM -1.5845915048275 0.0816761647481986 no 3106 0.0565295881733259 4563 6467338 SGTC_3345 9148410 3.559 µM -1.58466004085904 0.0816671010668999 no 3107 0.0565217976996639 4485 4903596 SGTC_3121 9125696 49.47 µM -1.58575533991029 0.0815223539808661 no 3108 0.0563974100939622 4636 1235365 SGTC_2 0422-0095 29 µM -1.58807850780714 0.0812159807805831 no 3109 0.0561342937905708 4458 6790840 SGTC_1556 plumbagin 1.48 µM -1.58861877564443 0.0811448563605289 no 3110 0.056073243327046 4472 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_287 k060-0039 29.6 µM -1.58888222767335 0.0811101908508291 no 3111 0.0560434921501453 4585 5861974 SGTC_304 1310-0298 97 µM -1.59184680970512 0.0807208757229835 no 3112 0.0557095647148473 4277 1550234 SGTC_2475 5812728 15.03 µM -1.59299699091535 0.080570212039009 no 3113 0.0555804330450104 4498 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1829 berberine 14.4 µM -1.59582556762695 0.080200596828057 no 3114 0.0552638716345899 4506 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1919 st067113 52.3 µM -1.59749614669946 0.0799829020494102 no 3115 0.0550775779652792 4510 1268243 SGTC_3229 9132204 49.47 µM -1.60614857006431 0.0788625406572169 no 3116 0.0541206351498033 4644 17682924 SGTC_3200 9114385 49.47 µM -1.60820917747841 0.0785974836105692 no 3117 0.0538946869292889 4516 17018030 YLR208W SEC13 SGTC_3130 9127414 49.47 µM -1.60959027011446 0.0784202112147276 no 3118 0.0537436668712703 4587 1494646 SGTC_3006 9075424 71.4286 µM -1.61175295398153 0.0781432256495576 no 3119 0.0535078547204463 4517 7465181 SGTC_917 harmaline 728.087 nM -1.61213076987663 0.0780949131481703 no 3120 0.0534667431245563 4479 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1720 st037298 9.481 µM -1.61478945108576 0.0777555798034895 no 3121 0.0531781491789204 4532 597396 SGTC_756 0508-1999 28.3 µM -1.61491152640876 0.0777400259771702 no 3122 0.0531649278854289 4576 6753853 SGTC_3243 9134147 49.47 µM -1.6190197556181 0.0772179654668298 no 3123 0.0527215062787909 4643 24282180 SGTC_2561 acetosyringone 100 µM -1.62343109397516 0.0766603571040475 no 3124 0.0522486411287245 4514 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_3323 9138564 53.9225 µM -1.62488363105619 0.0764774231615622 no 3125 0.0520936783332071 4574 43912313 YNL103W MET4 SGTC_2962 9082311 13.18 µM -1.62666541007489 0.0762534779258354 no 3126 0.0519040894640411 4533 16459453 SGTC_2259 7964009 200 µM -1.6303666604074 0.0757898769835557 no 3127 0.051512013290751 4575 313134 SGTC_248 streptozotocin 5.23457 mM -1.63159690426003 0.0756362588244316 no 3128 0.051382215411282 4598 5300 DNA alkylating agent. SGTC_2704 st078022 71.1 µM -1.63211551974039 0.0755715714406266 no 3129 0.05132757646884 4595 54697681 SGTC_1660 st012960 28.1 µM -1.63459325815791 0.0752631025127483 no 3130 0.0510671709488687 4566 24207266 SGTC_1937 st074714 47.2 µM -1.63700694578664 0.0749635315612629 no 3131 0.0508145091375904 4494 17250970 SGTC_134 0269-0018 6.916 µM -1.64218820959327 0.0743235400353339 no 3132 0.0502755026913514 4502 4378915 SGTC_3128 9127691 49.47 µM -1.64664650253402 0.073776196988617 no 3133 0.0498153631102276 4564 41316314 SGTC_1647 st011722 22.4 µM -1.6486043228517 0.0735368118537807 no 3134 0.0496143612745069 4559 2854783 SGTC_2973 9094665 17.96 µM -1.64879015669707 0.0735141206168027 no 3135 0.0495953161117647 4539 25237061 YIL048W NEO1 SGTC_3210 9128157 49.47 µM -1.65251573706031 0.073060337557699 no 3136 0.0492147298684075 4513 17590849 SGTC_1301 naphtanilide LB 4.81 µM -1.65794892211162 0.0724024115773572 no 3137 0.0486638882186542 4610 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_547 1120-0019 610 nM -1.66670953574424 0.0713511277699364 no 3138 0.0477860879319789 4551 3676939 SGTC_2620 irigenin 100 µM -1.66775622309818 0.0712263116866454 no 3139 0.0476820646888412 4551 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_482 fipronil 114 µM -1.6729172434009 0.0706133166212028 no 3140 0.0471717943689891 4682 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2013 4024628 200 µM -1.67489230977516 0.0703798057561336 no 3141 0.0469776813729861 4580 5230760 SGTC_604 1000-0114 314 µM -1.67558263001456 0.0702983297991945 no 3142 0.0469099867456163 4582 1572745 SGTC_743 1275-0778 158 µM -1.67765163392658 0.0700545673377088 no 3143 0.0467075632825898 4555 2849257 YMR203W TOM40 SGTC_374 0880-0231 82.3 µM -1.68103428076846 0.0696574376217948 no 3144 0.0463781280665335 4446 6833587 SGTC_3118 9124250 49.47 µM -1.68199331688033 0.0695451607431962 no 3145 0.0462850679276388 4550 1504786 SGTC_1976 st070609 63.5 µM -1.68471959216914 0.0692267496169199 no 3146 0.046021342332114 4538 682556 SGTC_224 benfluorex 43.875 µM -1.68870213777788 0.068763634627319 no 3147 0.0456382628820545 4590 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1442 4112-3290 3 µM -1.68887402890765 0.0687436999754432 no 3148 0.0456217866282034 4586 704353 SGTC_491 tetrandrine 80.3 µM -1.68977766161094 0.0686389766721339 no 3149 0.0455352494956154 4608 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1092 toremifene 6.32 µM -1.68978746900689 0.0686378407541188 no 3150 0.0455343110067641 4587 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2371 9071574 200 µM -1.69147295064427 0.068442839166501 no 3151 0.0453732548548696 4592 45596039 SGTC_593 1203-0218 61.7 µM -1.69180330114727 0.0684046694507648 no 3152 0.0453417419883967 4625 3666956 SGTC_1968 st069590 43.6 µM -1.69595634466257 0.0679262139998261 no 3153 0.0449470739097103 4556 6384066 SGTC_1694 st024011 44.9 µM -1.70108316734582 0.0673391423676912 no 3154 0.0444636856231119 4626 2787533 SGTC_2079 5212404 121 µM -1.70383946583015 0.067025144341545 no 3155 0.0442055413232882 4547 758462 SGTC_1498 4478-3555 97.6 µM -1.7104810372147 0.0662731876689369 no 3156 0.0435884785292379 4609 3437919 SGTC_844 0330-0132 15.3 µM -1.71413673400001 0.0658620877338245 no 3157 0.0432518083765299 4637 2828079 SGTC_1059 3448-6867 171 µM -1.71633391236682 0.0656159574717352 no 3158 0.0430504724063491 4563 3934407 SGTC_693 4161-2696 114 µM -1.71831242815574 0.0653949328088889 no 3159 0.0428698218404425 4622 805759 SGTC_193 1273-0060 1.558 µM -1.71874649170234 0.0653465198788585 no 3160 0.0428302712479903 4465 2847393 YHR072W ERG7 SGTC_2276 7947513 42.08 µM -1.73226875952918 0.063852205637215 no 3161 0.0416128607698195 4531 2105100 SGTC_1453 4237-0541 195 µM -1.73252142443331 0.0638245393170042 no 3162 0.0415903829459813 4599 739892 SGTC_1651 st011928 86.1 µM -1.73431172045185 0.0636287723677066 no 3163 0.0414313945073823 4604 720198 SGTC_675 1309-0189 238 µM -1.73569927663068 0.0634773662190491 no 3164 0.0413085107407175 4612 4246530 SGTC_855 0428-0020 25 µM -1.73683817245847 0.0633533028233626 no 3165 0.0412078695591253 4624 6812414 SGTC_1758 st042942 75.2445 µM -1.73851384856392 0.0631711095849574 no 3166 0.0410601560347048 4587 669317 SGTC_3014 9081533 49.47 µM -1.73921595473735 0.0630948922480189 no 3167 0.0409983920407818 4616 21367265 SGTC_2468 5987765 72.9 µM -1.7404323029123 0.0629630207563285 no 3168 0.0408915687542174 4640 26772094 SGTC_1172 0370-0043 85 µM -1.74120254638535 0.0628796252030122 no 3169 0.0408240405380625 4625 376585 SGTC_172 1112-0046 2.638 µM -1.74203373129665 0.062789727987048 no 3170 0.040751271035887 4594 2802135 YIL048W NEO1 SGTC_2558 carylophyllene oxide 100 µM -1.74399839675897 0.0625776367627955 no 3171 0.04057968469995 4676 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2037 5169046 200 µM -1.74407575519853 0.0625692971407577 no 3172 0.0405729405295593 4648 5718022 SGTC_778 3456-2434 196 µM -1.74705349430249 0.062248940212055 no 3173 0.0403140296533761 4524 5539063 SGTC_1967 st070177 51.4 µM -1.7504735239123 0.0618825800325893 no 3174 0.0400183194144473 4610 5729214 SGTC_2120 5538279 151.968 µM -1.75249390427232 0.0616669450236169 no 3175 0.0398444585607644 4610 2058197 SGTC_536 3852-0578 10.6 µM -1.75343953679802 0.0615662195215194 no 3176 0.039763294753429 4616 2869208 SGTC_293 4049-0273 38.5 µM -1.75515270932843 0.0613840655957042 no 3177 0.0396165952223485 4508 1380311 SGTC_82 0054-0107 293.755 µM -1.76173892747545 0.0606877006551632 no 3178 0.0390567087779768 4595 3104697 SGTC_1103 duloxetine 36.1 µM -1.76342784839281 0.0605101291388707 no 3179 0.0389141781783309 4660 60835 A selective serotonin reuptake inhibitor. SGTC_1289 0976-0073 69.1 µM -1.76612160042073 0.0602277522048248 no 3180 0.0386877251600028 4662 3391136 SGTC_189 3970-0742 2.116 µM -1.77212841923633 0.0596017928609721 no 3181 0.0381866211968998 4596 2891807 SGTC_3145 9085516 49.47 µM -1.77476834871646 0.0593283085450819 no 3182 0.0379680722531946 4596 25236195 SGTC_726 3448-4391 34.2 µM -1.77798893784749 0.0589960040387269 no 3183 0.037702835870659 4673 1356692 SGTC_1830 st055982 50.3 µM -1.77996059739015 0.0587932874074629 no 3184 0.0375412046895192 4611 455313 An antimicrobial agent. SGTC_361 000s-0510 1.45 µM -1.78097807959802 0.0586888887958192 no 3185 0.0374580159115303 4522 660 SGTC_2379 9035213 200 µM -1.78160800711947 0.0586243281418431 no 3186 0.037406588886298 4621 646551 SGTC_857 0438-0306 1.35 µM -1.78483351227907 0.0582946225088824 no 3187 0.0371441628886808 4651 4686136 SGTC_2369 9071472 200 µM -1.78599614375582 0.0581761380596567 no 3188 0.0370499412594112 4626 17296037 SGTC_2754 granisetron 64.02 µM -1.79061531808874 0.0577072635370142 no 3189 0.0366775235945057 4603 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1675 st018485 24.5 µM -1.79124836183767 0.0576432378888036 no 3190 0.0366267242927585 4604 3323024 SGTC_2451 5856223 45.7 µM -1.79497525563118 0.0572674340541285 no 3191 0.0363288212206847 4608 2179896 SGTC_2105 5350118 200 µM -1.79691519464244 0.0570725834451737 no 3192 0.0361745420120413 4598 2133313 SGTC_1795 st049545 62.3 µM -1.79832560509991 0.0569312474868381 no 3193 0.0360627122037966 4599 5291882 SGTC_1311 1190-0148 100 µM -1.80145255921238 0.056618881151163 no 3194 0.0358157891640932 4646 1961333 SGTC_261 5-fluorouridine 15.376 µM -1.80242309975873 0.0565222043139929 no 3195 0.0357394317781548 4630 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_757 1066-0008 322 µM -1.80296137659361 0.0564686419470603 no 3196 0.0356971403326377 4628 6842497 SGTC_2520 obtusaquinone 4.71 µM -1.80317599226477 0.0564472973210919 no 3197 0.0356802898047788 4638 5967872 SGTC_2869 9037858 32.47 µM -1.80418420457666 0.0563471105377878 no 3198 0.0356012173432318 4588 27187042 SGTC_2308 7584454 197.62 µM -1.80780712730709 0.0559882544865165 no 3199 0.0353182620546938 4596 893577 SGTC_1044 1222-0021 1.78 µM -1.8140099131165 0.0553780468858378 no 3200 0.0348380997983576 4566 4306703 SGTC_586 0957-0265 8.15 µM -1.82207844060492 0.0545921668057031 no 3201 0.0342215422391689 4554 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3303 9125618 40.5795 µM -1.82534981995757 0.0542760558757549 no 3202 0.0339741282792695 4615 22695467 SGTC_1445 4239-0156 97.7 µM -1.83212390843158 0.0536260861249667 no 3203 0.0334664810458522 4667 4008346 SGTC_896 0964-0007 44.5 µM -1.8348958931189 0.0533619000889738 no 3204 0.0332605581552892 4606 6756758 SGTC_2110 5483698 200 µM -1.83535610378517 0.0533181393819296 no 3205 0.0332264716308865 4629 2848765 YHR062C RPP1 SGTC_2567 aureobasidin a 60 nM -1.83724482800035 0.0531388414084473 no 3206 0.0330868803151021 4662 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2837 9008476 45.46 µM -1.84084636218908 0.0527982702843108 no 3207 0.0328220382676313 4601 2992805 SGTC_2598 perillyl alcohol 100 µM -1.84460252876494 0.0524449238421733 no 3208 0.0325476894447995 4628 10819 An apoptosis inducer. SGTC_1718 roemerine 11.9335 µM -1.8472422785442 0.0521977250237054 no 3209 0.0323560172073452 4245 235224 An aporphine alkaloid with mutagenic activity. SGTC_868 0527-0199 213 µM -1.84774343639633 0.0521508988886143 no 3210 0.0323197335405879 4629 2849450 SGTC_1252 0493-0875 34.8 µM -1.85455224581865 0.0515180121450443 no 3211 0.0318300964204381 4612 3960963 SGTC_1147 3809-1045 12.3 µM -1.85799454433209 0.0512003790460987 no 3212 0.0315848945296002 4663 325925 SGTC_2644 guaiazulene 100 µM -1.86139050494209 0.0508885505332682 no 3213 0.0313445252385452 4681 3515 A coloring agent. SGTC_2694 st077685 81.9 µM -1.86415663891705 0.0506356737536328 no 3214 0.0311498552980742 4575 2838096 SGTC_1983 st071813 46.9 µM -1.86611263834776 0.0504574633989743 no 3215 0.0310128040661776 4683 11838595 SGTC_1015 4130-4525 82 µM -1.86645637992438 0.0504261969252091 no 3216 0.0309887707104173 4637 1363237 SGTC_1291 0993-0025 5.79 µM -1.87451511378317 0.0496975943047473 no 3217 0.0304297304474744 4641 4353356 SGTC_2077 5212015 200 µM -1.88224767192011 0.0490064021583413 no 3218 0.029901197861842 4596 780900 SGTC_1262 0737-0114 49.6 µM -1.88553211048561 0.0487151486995054 no 3219 0.0296790167075942 4666 765919 SGTC_3339 9145883 14.936 µM -1.89551700027963 0.047838210034468 no 3220 0.0290119708330026 4596 2030670 SGTC_1293 1000-1278 195 µM -1.89645029037827 0.0477568923987157 no 3221 0.02895026363084 4670 678847 SGTC_2426 5582046 32.21 µM -1.92316710583502 0.0454756285767715 no 3222 0.0272295334474505 4635 2251934 SGTC_1284 0929-0043 16 µM -1.92544229338811 0.0452854771107745 no 3223 0.0270870243940655 4665 1239883 SGTC_588 3970-1144 52.9 µM -1.94893002492636 0.0433596224560716 no 3224 0.0256518909268862 4605 1888707 SGTC_1499 4480-0877 67.3 µM -1.95430167248488 0.0429286030946232 no 3225 0.0253327755942847 4684 2861909 SGTC_3036 9090181 49.47 µM -1.95891479640286 0.0425612167969111 no 3226 0.0250613829540928 4720 25236586 SGTC_73 0327-0325 16.231 µM -1.95955940820576 0.0425100833703461 no 3227 0.0250236548688386 4503 53298 SGTC_2580 diallyl disulphide 81.36 µM -1.96006214348014 0.0424702387020335 no 3228 0.0249942636457247 4640 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_704 1310-0270 142 µM -1.97424720663709 0.0413583855951866 no 3229 0.0241768203251416 4652 5718033 SGTC_929 2805-0021 398 µM -1.97498781933727 0.0413009891468032 no 3230 0.0241347651609929 4685 3098024 SGTC_2663 amphotericin b 100 µM -1.97799926442615 0.0410682710529216 no 3231 0.023964394820172 4700 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2415 st077333 57.7 µM -1.98000170246287 0.0409141163524282 no 3232 0.0238516686919569 4650 2766255 SGTC_3181 9108277 49.47 µM -1.98018534217265 0.0409000026520889 no 3233 0.0238413531464354 4676 17097298 SGTC_2089 5281248 129.67 µM -1.98318338733513 0.0406701448106755 no 3234 0.0236734744212191 4676 2737878 SGTC_1606 st000094 49.2 µM -1.98321892108176 0.0406674267649611 no 3235 0.0236714906475739 4701 1242210 SGTC_535 2293-4129 48.2 µM -1.99051618462935 0.0401123609361471 no 3236 0.0232670514658755 4661 396118 YIL048W NEO1 SGTC_1022 4477-0945 21.3 µM -1.99151467943978 0.0400368915015566 no 3237 0.0232121665079745 4634 4648966 SGTC_533 1222-0222 6.71 µM -1.9931273695858 0.0399152429163898 no 3238 0.0231237508378358 4707 3982874 SGTC_117 lucigenin 22.078 µM -1.99530064227018 0.0397517837993703 no 3239 0.0230050499523062 4630 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1999 st074831 12.5 µM -2.00790800648371 0.0388142471999325 no 3240 0.0223265341119317 4668 17112523 SGTC_1419 3993-2473 62.6 µM -2.0222985641791 0.0377661993925938 no 3241 0.021572758440893 4738 704026 SGTC_809 3998-0021 90 µM -2.02503240487244 0.0375697315794442 no 3242 0.0214320184459051 4663 715485 SGTC_2516 gossypol 71.55 µM -2.04409368056 0.0362229721379738 no 3243 0.0204721466682467 4701 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2313 7726885 200 µM -2.04575086136639 0.0361077769313625 no 3244 0.0203904444288156 4677 726423 SGTC_3350 9150499 3.57 µM -2.04836873991927 0.0359264123848556 no 3245 0.0202619410728755 4688 4910996 YPR165W RHO1 SGTC_1196 1588-0294 184 µM -2.04903159112746 0.0358806091698858 no 3246 0.0202295129549331 4726 6144269 SGTC_1452 4194-0072 190 µM -2.05576877770098 0.0354177764786343 no 3247 0.019902404436 4714 1343545 SGTC_2595 hexamethylquercetagetin 100 µM -2.06934137079488 0.0345002270573598 no 3248 0.0192570320120973 4664 386331 SGTC_623 k072-0108 16.9 µM -2.07349138059879 0.0342236037741913 no 3249 0.0190632862290406 4691 5382803 SGTC_3301 9125354 19.7965 µM -2.08199781358302 0.0336622959590886 no 3250 0.018671334716355 4682 41905162 SGTC_17 0960-0276 49.807 µM -2.08581641327116 0.0334127961892808 no 3251 0.0184976280363552 4705 6821114 SGTC_2868 9035608 32.47 µM -2.09196745482247 0.0330141023743983 no 3252 0.0182207135576097 4693 6462614 SGTC_1150 3909-7983 10.9 µM -2.10016782486869 0.0324886817951558 no 3253 0.0178570403222248 4715 23965914 SGTC_2348 9022543 33.42 µM -2.10678176578703 0.0320699507843906 no 3254 0.0175682503852589 4711 3162678 YDL140C RPO21 SGTC_1920 st075728 45.7 µM -2.1067820328061 0.032069933969698 no 3255 0.0175682388071452 4681 3400306 SGTC_2465 5809242 33.21 µM -2.11393180476762 0.0316223018021318 no 3256 0.0172605461549775 4751 2731748 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -2.11964527147077 0.0312683165574852 no 3257 0.0170179857940461 4738 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2051 5263410 176 µM -2.13286209777514 0.0304619978667744 no 3258 0.0164680201862996 4664 227584 SGTC_2273 7815444 169.05 µM -2.1402818619188 0.0300169406850269 no 3259 0.0161659974558836 4656 2824616 SGTC_2586 curcumin 80 µM -2.14116079278624 0.0299645790800483 no 3260 0.0161305367953897 4630 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1435 4092-0789 56.7 µM -2.15854201602272 0.0289445706422091 no 3261 0.0154428576955342 4728 2248285 SGTC_1300 1094-0077 113 µM -2.16434925942453 0.0286102742130483 no 3262 0.0152187774372335 4722 5532636 SGTC_2664 lyso-paf C-16 73.48 µM -2.17110450484454 0.0282254523426459 no 3263 0.0149616367995249 4714 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2626 ethyl orsellinate 100 µM -2.17344247477409 0.0280932743706671 no 3264 0.0148735154764019 4669 75653 A natural product. SGTC_786 4544-0069 423 µM -2.18350167815012 0.0275304391416988 no 3265 0.014499442755833 4695 748821 YLR208W SEC13 SGTC_1706 st031321 9.9705 µM -2.18839264580249 0.0272601935345699 no 3266 0.0143205067590302 4736 6103185 SGTC_2597 laccaic acid a 100 µM -2.21637181267059 0.0257564377239296 no 3267 0.0133330242506939 4682 5491415 A textile dye. SGTC_3039 9090270 49.47 µM -2.24797370904667 0.0241421034348622 no 3268 0.0122889332115274 4724 17173750 SGTC_3134 9127454 49.47 µM -2.25880913143738 0.0236085347953884 no 3269 0.0119476301365456 4725 24262820 SGTC_2326 6164455 177.58 µM -2.26979822157635 0.0230775643096024 no 3270 0.0116099142677891 4682 2888790 SGTC_2905 7799065 20.05 µM -2.27026437060209 0.0230552650883269 no 3271 0.0115957737278846 4674 1296806 SGTC_1052 3253-3998 198 µM -2.27829966050136 0.0226737233347023 no 3272 0.011354364941565 4711 5450317 SGTC_2347 9049783 174.81 µM -2.28452061063757 0.0223820000213736 no 3273 0.0111704763538174 4709 6467988 YPL169C MEX67 SGTC_1414 3917-0015 5.4 µM -2.28459509775335 0.0223785263165307 no 3274 0.0111682903276918 4755 6618702 SGTC_2171 5739187 198.077 µM -2.29335809649037 0.0219730256088077 no 3275 0.0109136985101993 4716 2262761 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.31829329961471 0.0208529634996196 no 3276 0.0102166931611429 4744 803109 SGTC_3198 9112019 49.47 µM -2.32501406382424 0.0205594774134581 no 3277 0.0100356040985455 4740 45595555 SGTC_40 0327-0103 19.753 µM -2.32687232278277 0.0204789501462298 no 3278 0.00998603084146246 4623 409036 SGTC_1225 1216-0074 20.6 µM -2.34378841564706 0.0197581083670473 no 3279 0.00954449849172929 4746 4241466 SGTC_2880 9042983 58.44 µM -2.3487580595805 0.0195504756910269 no 3280 0.00941807080184454 4700 6464714 SGTC_1552 6-methylflavone 10.6 µM -2.35069101043369 0.0194702186865189 no 3281 0.00936929362434937 4736 689013 SGTC_1448 4255-0083 152 µM -2.35446556596931 0.0193143040720073 no 3282 0.0092746811081842 4755 5399660 SGTC_2850 9015429 58.44 µM -2.36044920444858 0.0190693139614395 no 3283 0.00912640891797568 4731 6457570 SGTC_2892 9047358 58.44 µM -2.36432452034765 0.0189120595287831 no 3284 0.00903149114679381 4745 6466771 SGTC_423 5-fluorouracil 457 µM -2.37502861475504 0.0184834239913392 no 3285 0.00877379489173301 4708 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2264 7948757 110.76 µM -2.37683334794809 0.0184119763018854 no 3286 0.00873098769966408 4718 2971411 SGTC_2913 7966556 36.57 µM -2.38481825987079 0.0180986773805125 no 3287 0.00854378029002692 4671 2976516 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.3896629820812 0.0179108120198825 no 3288 0.00843191981250095 4700 676296 Flavone; oxidizing agent. SGTC_1898 st060199 18.6 µM -2.39532100705093 0.0176935166573176 no 3289 0.00830290993630796 4753 688866 SGTC_2831 7999036 19.48 µM -2.40151067808417 0.0174583840224149 no 3290 0.008163766266422 4713 2988270 SGTC_1978 st071761 42 µM -2.41264381025157 0.0170421721034058 no 3291 0.00791864412650512 4754 5147680 SGTC_997 3996-0078 137 µM -2.41363635328524 0.0170054811341281 no 3292 0.00789710848066876 4760 735687 SGTC_1310 1188-0297 994 nM -2.41778858574817 0.016852718381094 no 3293 0.00780757317856806 4701 1588352 SGTC_1240 0356-0016 42.1 µM -2.42347532455596 0.0166454057376693 no 3294 0.00768639879412096 4728 4305613 SGTC_1699 st031318 29.054 µM -2.43526710028372 0.0162224768199064 no 3295 0.00744040034856836 4784 5340658 SGTC_1767 st044992 70.3 µM -2.44041793949379 0.0160406433626933 no 3296 0.007335139263421 4744 9600693 SGTC_1368 1852-0141 284 µM -2.44805223272445 0.0157743541856115 no 3297 0.0071815415994493 4712 2838987 SGTC_566 0958-0068 16.5 µM -2.45676509848872 0.0154750851639986 no 3298 0.00700971613302625 4720 6815365 SGTC_3328 9140624 29.0385 µM -2.45713502263466 0.0154624876240142 no 3299 0.00700250188712104 4748 4904392 SGTC_2858 9025781 8.96 µM -2.46447073886005 0.0152144864676217 no 3300 0.00686078834316316 4616 4894980 YPL153C RAD53 SGTC_1380 2291-0730 164 µM -2.4659539498443 0.0151647604604813 no 3301 0.00683244504569401 4748 2999191 SGTC_151 3013-0144 2.285 µM -2.46995356553131 0.0150313650598527 no 3302 0.00675652957130998 4557 906558 YHR107C CDC12 SGTC_289 k017-0060 526 µM -2.47532111072022 0.0148539321530074 no 3303 0.00665582150977325 4757 5512909 SGTC_1941 st076221 61.8 µM -2.49448292037255 0.0142351219354336 no 3304 0.00630703984810326 4695 2828568 SGTC_410 α-linolenic acid 100 µM -2.502415922265 0.0139855089728304 no 3305 0.00616744598213765 4766 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_792 4534-1957 155 µM -2.50679799512178 0.0138492510630512 no 3306 0.00609151575736978 4748 1717904 SGTC_795 0685-0265 78 µM -2.51829586267789 0.0134971621482742 no 3307 0.00589621092828042 4759 302754 SGTC_769 0302-0231 76 µM -2.53322703133881 0.0130514910631325 no 3308 0.00565088634674573 4711 571869 YER009W NTF2 SGTC_335 4077-0256 27.6 µM -2.53986690837789 0.0128574237718898 no 3309 0.00554473297962258 4681 3121989 SGTC_3201 9113999 49.47 µM -2.54889620305238 0.0125975274324382 no 3310 0.00540322291464555 4734 16649224 SGTC_2655 perillic acid 100 µM -2.56859388839337 0.0120462914906111 no 3311 0.00510560233568542 4785 5702197 An apoptosis inducer. SGTC_722 3534-0461 190 µM -2.57380483622401 0.0119040098142833 no 3312 0.00502934971547404 4763 658262 SGTC_545 4218-0007 221 µM -2.5879505140219 0.0115250975142382 no 3313 0.00482744249701188 4775 2840508 SGTC_1799 st045822 46.1415 µM -2.6219034389343 0.0106580933636896 no 3314 0.00437201007556796 4769 3674992 SGTC_2080 5212524 12.4 µM -2.63351689405567 0.0103748645722788 no 3315 0.00422528157863997 4749 260183 SGTC_2967 9089538 49.85 µM -2.6393450471528 0.0102352165808694 no 3316 0.00415331936334055 4747 728216 SGTC_1619 st003326 88.7 µM -2.64642447659811 0.010067794255736 no 3317 0.00406738338088594 4749 2849032 SGTC_773 4358-1457 44.6 µM -2.65692316039372 0.00982391043822639 no 3318 0.00394287073030977 4772 1186886 SGTC_3028 9087778 49.47 µM -2.69043970909501 0.00907952057414802 no 3319 0.00356789638678453 4760 17217395 SGTC_972 1319-0219 195 µM -2.70939130137409 0.00868086319090558 no 3320 0.00337033942605299 4776 23903702 SGTC_2965 9082772 38.63 µM -2.7280878971442 0.00830269556253707 no 3321 0.00318513156002199 4763 16459634 SGTC_1531 st059297 52.4 µM -2.72864438391451 0.00829166498727553 no 3322 0.00317976217141303 4785 7566702 SGTC_1490 4089-0339 670 nM -2.73866410229312 0.00809524640460977 no 3323 0.00308446824750165 4795 742542 SGTC_567 1080-0542 68.4 µM -2.77226023324296 0.00746617788435056 no 3324 0.00278342564781583 4743 5950415 SGTC_725 1497-0963 19 µM -2.77861717162738 0.00735211740204147 no 3325 0.00272954103761826 4792 3549977 SGTC_1189 1431-2119 7.28 µM -2.7975941885834 0.00702070361845955 no 3326 0.00257423767971019 4784 3107275 SGTC_422 cantharidin 155 µM -2.80323119191471 0.00692483320061457 no 3327 0.00252966938224413 4749 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2943 9068529 45.32 µM -2.83442333145569 0.00641494875389705 no 3328 0.00229542361440338 4756 3270634 SGTC_988 1497-1057 103 µM -2.85154848891993 0.00614938051843868 no 3329 0.00217534250506654 4786 3533044 SGTC_984 1492-0255 2.91 µM -2.8829845907388 0.00568713382445005 no 3330 0.00196963355185219 4773 1585198 SGTC_2653 dihydrofissinolide 100 µM -2.88697221280205 0.00563076001727593 no 3331 0.00194484290379853 4803 6857746 SGTC_2059 5238311 157 µM -2.88963364868927 0.00559341141692355 no 3332 0.00192845509344662 4775 703021 SGTC_788 1182-0090 188 µM -2.90374422657009 0.00539904627712202 no 3333 0.00184364628762808 4768 5715185 SGTC_626 0214-0009 33 µM -2.93509940661413 0.00498849236315544 no 3334 0.00166720423622157 4791 3437874 SGTC_116 0155-0182 31.788 µM -2.95169503405556 0.00478265047632269 no 3335 0.00158017445764921 4748 771486 SGTC_1889 st059080 5.18 µM -2.95471350683656 0.00474603604557932 no 3336 0.00156479761048245 4777 176925 Isolated from Daphnopsis sellowiana. SGTC_3032 9089427 49.47 µM -2.95488715386188 0.0047439373113123 no 3337 0.00156391717301318 4770 17173707 SGTC_266 formosanin C 406 nM -2.9553071599291 0.00473886445189214 no 3338 0.00156178949536853 4736 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_444 curcumin 90.4 µM -3.02212540907122 0.0039908712058189 no 3339 0.00125503266957115 4738 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2648 atorvastatin 78.68 µM -3.07688610565709 0.0034586544297898 no 3340 0.00104587603837625 4792 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1480 1070-0044 41.2 µM -3.1463118378092 0.00287594047781303 no 3341 0.000826718064195659 4806 3124987 SGTC_2974 9094440 9.66 µM -3.18306773480396 0.00260471157016526 no 3342 0.00072861760042025 4782 25236134 SGTC_2651 TUB2.036 5 µM -3.18963835820606 0.00255873582929772 no 3343 0.000712254659854254 4720 15992207 YFL037W TUB2 SGTC_3123 9126162 49.47 µM -3.27587222680513 0.00201971366876275 no 3344 0.000526681024390342 4794 25239884 SGTC_1475 4092-1048 11.7 µM -3.28932094722361 0.00194563370563301 no 3345 0.000502147164440493 4796 2881759 SGTC_2448 5185112 27.17 µM -3.34813176968543 0.00164982492558498 no 3346 0.000406791591271131 4796 5718189 SGTC_2240 6690706 185.951 µM -3.36056327420232 0.00159280025845413 no 3347 0.000388918558177531 4776 805876 SGTC_2656 pseudo-anisatin 100 µM -3.45096908593514 0.00122921461396803 no 3348 0.000279288773310514 4810 6708809 A neurotoxin. SGTC_2971 9092186 9.93 µM -3.80276755290889 0.00042419000000864 yes 3349 7.15443001644436e-05 4786 25236400 SGTC_3296 9122258 64.045 µM -3.92713785177577 0.00028507755390038 yes 3350 4.29813582327124e-05 4803 4730474 SGTC_2352 9027995 87.8 µM -4.00618157996051 0.000220164586340586 yes 3351 3.08541088057033e-05 4787 2997347 SGTC_2342 7990637 118.86 µM -4.57842015774902 2.96216066770059e-05 yes 3352 2.34250461962726e-06 4808 2033102 YER133W GLC7 SGTC_1280 0880-0253 10.1 µM -4.60508604937262 2.68216687894854e-05 yes 3353 2.06147671069764e-06 4810 6836607