SGTCid condition conc unit BUD19|YJL188C.score BUD19|YJL188C.strain.pval BUD19|YJL188C.strain.significant BUD19|YJL188C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_800 3448-7362 155 µM 10.0554786421198 4.00361505872767e-23 yes 1 4.34490600722191e-24 6 15991913 SGTC_118 0083-0097 135.343 µM 9.08688824955031 2.81986495113567e-19 yes 2 5.09570251404685e-20 3 5207356 SGTC_625 k213-0058 121 µM 6.11123039051354 8.45246619871277e-10 yes 3 4.94329576832301e-10 34 3655420 SGTC_832 4083-0019 164 µM 5.50759036091174 2.63325364303597e-08 yes 4 1.8188934748784e-08 26 1990758 SGTC_2688 kanamycin b 96.69 µM 5.36760898710106 5.57595683925296e-08 yes 5 3.98936476736195e-08 207 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_2501 sodium tetradecyl sulfate 13.37 µM 5.2945670080046 8.18985551417698e-08 yes 6 5.96493697015602e-08 13 23665772 A membrane-active detergent. SGTC_2335 9018011 154.17 µM 5.1906735480028 1.40327302644203e-07 yes 7 1.04767358376441e-07 9 6458208 SGTC_1849 st056239 19.2 µM 5.07445917112191 2.53351778420245e-07 yes 8 1.94299828038059e-07 8 5393181 SGTC_3334 9142812 21.919 µM 5.06603084650816 2.64317748480385e-07 yes 9 2.03098061342245e-07 12 45283678 SGTC_1989 st071868 50.2 µM 4.90968063904859 5.73396483771154e-07 yes 10 4.56124171791437e-07 4 16414057 SGTC_3254 9136651 49.47 µM 4.89527737471838 6.15115798510281e-07 yes 11 4.90835836365587e-07 11 16454030 SGTC_2078 5212016 200 µM 4.66176950969547 1.87130825647739e-06 yes 12 1.56751090439695e-06 5 1899708 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 4.62690413584145 2.20021199899513e-06 yes 13 1.85586104957357e-06 15 6708760 SGTC_1327 1436-0082 2.18 µM 4.60829093833117 2.39778932122382e-06 yes 14 2.02996155123784e-06 11 15992205 SGTC_2536 dehydroabietamide 32.04 µM 4.52683910429628 3.48058542304539e-06 yes 15 2.99362449169506e-06 20 3983547 SGTC_2336 9001819 198.65 µM 4.46272434567326 4.64759835232041e-06 yes 16 4.04620648042918e-06 34 2989602 SGTC_2866 9034245 58.44 µM 4.45389428568128 4.83501686930334e-06 yes 17 4.21633160282285e-06 3 6462273 SGTC_911 3456-4043 236 µM 4.43214306449167 5.32797651988406e-06 yes 18 4.66505374095612e-06 19 914281 SGTC_1670 st016595 4.04 µM 4.29484583143963 9.73794839571529e-06 yes 19 8.74073879251544e-06 6 597879 SGTC_2375 9072683 200 µM 4.23478249378887 1.26107909218519e-05 yes 20 1.14386514589672e-05 13 16798029 SGTC_1827 berberine 7.24 µM 4.0886289789206 2.33401998301657e-05 yes 21 2.16965126231484e-05 16 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1007 4101-0031 70 µM 4.01840007113794 3.11628145598145e-05 yes 22 2.92973245747919e-05 18 1146276 SGTC_830 4076-0286 57.8 µM 3.97319104326977 3.74488560939963e-05 yes 23 3.54580625082276e-05 56 6866659 SGTC_2823 7987624 58.44 µM 3.82952565396529 6.63438973217842e-05 yes 24 6.41952494840021e-05 32 2239440 SGTC_851 0394-0702 453 µM 3.72027190890191 0.000101240929250455 yes 25 9.95042016389584e-05 19 762646 SGTC_159 3970-0959 50 µM 3.71303395752473 0.000104076932243265 yes 26 0.000102394698494526 89 6615653 SGTC_2959 9079155 11 µM 3.67859965026899 0.000118620809832069 yes 27 0.000117259030204463 35 16189457 SGTC_1342 1486-1464 234 µM 3.66774086977037 0.000123589137661918 yes 28 0.000122351496522254 22 3253938 SGTC_3011 9081274 71.4286 µM 3.51160402303486 0.000220398433563856 yes 29 0.000222705555327752 30 6625322 SGTC_3250 9135583 49.47 µM 3.45794291014167 0.000267545547738962 yes 30 0.000272158357716246 17 7699353 SGTC_2455 5377712 9.75 µM 3.41233552715141 0.000314838177287319 yes 31 0.000322043907878642 35 2243908 SGTC_991 3996-0057 64.7 µM 3.39199022546323 0.000338349848234431 yes 32 0.000346934577274487 36 715343 SGTC_2295 7971645 200 µM 3.36949616457816 0.000366238901404237 yes 33 0.000376528695949999 46 2978226 YKL099C UTP11 SGTC_3126 9127922 49.47 µM 3.36783097011347 0.00036838612860289 yes 34 0.000378810149447095 59 45595682 SGTC_2365 9042475 200 µM 3.34724171461721 0.000395919528321074 yes 35 0.000408100039500247 70 6464479 SGTC_37 0566-0070 1.56 µM 3.3344785137612 0.00041393383596331 yes 36 0.000427297512581677 54 1626686 SGTC_177 1327-0068 8.361 µM 3.28947881113009 0.000483690966518715 yes 37 0.000501865568197127 72 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_114 0364-0001 490.298 µM 3.28461072269725 0.000491856983064084 yes 38 0.000510616814443798 86 4003655 SGTC_2388 9080168 200 µM 3.28398501526168 0.000492915790305904 yes 39 0.000511751820840636 19 15943073 SGTC_791 1348-1292 225 µM 3.27737710793236 0.000504227087238912 yes 40 0.000523881647176103 72 5437054 SGTC_31 0508-1974 57.237 µM 3.2598758561846 0.000535356634564049 yes 41 0.000557304945000288 53 6810525 SGTC_2402 5553605 200 µM 3.25110516396407 0.000551617173739774 yes 42 0.00057478663439676 65 6758546 SGTC_2804 7954240 19.48 µM 3.2431289384347 0.000566800127507818 yes 43 0.000591123476038009 63 828705 SGTC_808 0711-0032 135 µM 3.2369847000682 0.000578758258531062 yes 44 0.000603999440863032 36 4252555 SGTC_3248 9135562 49.47 µM 3.2291794575764 0.000594285325417536 yes 45 0.000620729825385885 26 17650701 SGTC_1761 st044296 37 µM 3.21980924761025 0.000613433682407219 yes 46 0.000641379606380948 28 1826700 SGTC_2985 9022375 71.43 µM 3.21043873723655 0.000633151106491717 yes 47 0.000662662578589861 59 4939335 SGTC_3327 9140648 26.9345 µM 3.20597548220663 0.000642746952722258 yes 48 0.000673027284339054 29 8029710 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 3.19884729175079 0.000658351092486492 yes 49 0.000689891170199299 35 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2643 anethole 100 µM 3.18901307568343 0.000680453132008734 yes 50 0.000713797100405664 43 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3240 9133527 49.47 µM 3.18782540005755 0.000683168218144956 yes 51 0.000716735328785298 32 17617455 SGTC_3244 9134489 49.47 µM 3.17095418203251 0.000722831390271751 yes 52 0.00075969553030286 45 16584271 SGTC_1358 1509-0022 2.48 µM 3.16336165759419 0.000741364398603553 yes 53 0.000779792276663961 36 3258434 SGTC_1969 st069479 40.1 µM 3.13621191681529 0.00081127608515149 yes 54 0.000855727436070752 30 3895485 SGTC_2651 TUB2.036 5 µM 3.13334753755218 0.00081899541755166 yes 55 0.00086412338617342 229 15992207 YFL037W TUB2 SGTC_2822 7994718 71.43 µM 3.09593614375582 0.00092621843541707 yes 56 0.000980963036108638 40 1018011 SGTC_2978 9011784 42.97 µM 3.05042147507284 0.00107400323091967 no 57 0.00114260214294578 81 2994934 SGTC_1990 st072050 59.8 µM 3.02274443300093 0.00117413696227252 no 58 0.00125246846300115 46 17233948 SGTC_2775 cyproheptadine 69.59 µM 2.99626765827652 0.00127785847869065 no 59 0.00136653211821268 43 2913 A selective serotonin reuptake inhibitor. SGTC_62 0180-0423 3.232 µM 2.98843579580954 0.00131010762100934 no 60 0.00140204704176948 59 30102 YGL099W LSG1 SGTC_1826 st055655 41.6 µM 2.9810867315204 0.00134104365362197 no 61 0.00143613716293164 87 676168 SGTC_2726 cimetidine 79.27 µM 2.97461219441966 0.00136884995506378 no 62 0.00146679578378201 24 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_33 0986-0033 35.816 µM 2.97419743185839 0.00137064906965285 no 63 0.0014687800034883 47 2848082 SGTC_1232 0279-0259 161 µM 2.96842533715627 0.00139591189691978 no 64 0.00149664906005476 72 1560000 SGTC_1171 0368-0077 21.4 µM 2.95056184856288 0.00147681367476385 no 65 0.00158598265529291 55 3239779 SGTC_1107 amlodipine 47 µM 2.9207499925865 0.00162140630503761 no 66 0.00174594959167784 82 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2081 5214970 32.255 µM 2.88608377265221 0.00180569164420323 no 67 0.00195034157831375 77 2063512 SGTC_250 brefeldin a 552.239 µM 2.87742893805778 0.00185457897328489 no 68 0.00200465100280714 49 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3249 9135183 49.47 µM 2.87578308734694 0.00186401070294581 no 69 0.00201513283918779 69 4902779 SGTC_2118 5526350 200 µM 2.8564531461341 0.00197809271149851 no 70 0.00214201614158105 64 743594 SGTC_163 TUB2.036 7.546 µM 2.82741388244119 0.00216142368766943 no 71 0.00234628175109451 211 15992207 YJR013W GPI14 SGTC_2090 5301565 104.445 µM 2.81836163650668 0.00222164469588896 no 72 0.00241347049848434 107 2056344 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.81420701772219 0.0022497894704738 no 73 0.0024448863848691 246 16725076 SGTC_1022 4477-0945 21.3 µM 2.78252384254012 0.00247527195968471 no 74 0.00269689509965517 83 4648966 SGTC_2878 9043973 25.97 µM 2.77272159467235 0.00254906209752273 no 75 0.00277948285093533 66 6465167 SGTC_41 0478-0632 82.643 µM 2.75638199752774 0.00267649448230203 no 76 0.00292223483641586 103 3750424 SGTC_1467 k284-1082 293 µM 2.73529468770867 0.00284944820948582 no 77 0.00311622262937048 78 3334705 SGTC_451 chloral hydrate 100 µM 2.72435661697889 0.00294307433187015 no 78 0.00322134491461966 148 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_422 cantharidin 155 µM 2.71201454712154 0.00305204062734949 no 79 0.00334378289308942 145 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_849 0386-0493 241 µM 2.70003845363892 0.00316123580577694 no 80 0.00346657310097799 78 726119 SGTC_1064 honokiol 6.76 µM 2.68166378023663 0.00333561684444599 no 81 0.00366285226258368 94 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2713 st079149 53.4 µM 2.67411886078253 0.00340969061046973 no 82 0.00374629451773198 96 3103253 SGTC_2356 9061756 188.97 µM 2.65935800076515 0.00355889673292391 no 83 0.00391448621475411 56 20104043 SGTC_1354 1498-1681 81 µM 2.64926382617527 0.00366427904068623 no 84 0.00403336658348662 104 5754243 SGTC_2232 chlorophetanol 41.5365 µM 2.59543488551639 0.0042749461954301 no 85 0.00472356507084632 241 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3108 9121785 49.47 µM 2.5820824286311 0.0044398601822149 no 86 0.00491030629171368 90 17140271 SGTC_1127 asiatic acid 681.4 nM 2.56017420683502 0.0047227823614435 no 87 0.0052309852603829 126 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2041 5107442 45.335 µM 2.55878529346184 0.00474124924604034 no 88 0.0052519296453913 126 793005 SGTC_190 3970-0790 3.722 µM 2.55509328150504 0.00479065145172983 no 89 0.0053079672057361 71 2832352 SGTC_2664 lyso-paf C-16 73.48 µM 2.54550757539326 0.00492106556023674 no 90 0.00545594980920149 100 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2441 5730946 39.09 µM 2.54103076901864 0.00498304936957215 no 91 0.00552630961786014 114 1774275 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.53667447629414 0.00504403124123519 no 92 0.00559554805339113 81 2724278 An inhibitor of dopamine biosynthesis. SGTC_2728 chlorpromazine 9.18 µM 2.53501658354385 0.00506741339065997 no 93 0.00562210014329407 42 2726 A thorazine and dopamine antagonist. SGTC_968 1309-0633 340 µM 2.51192941195278 0.00540320107755386 no 94 0.00600365517513762 84 3761976 SGTC_112 phenothiazine 287.218 µM 2.50449867779461 0.00551540768778311 no 95 0.00613125318003567 86 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1996 st072960 66.8 µM 2.48998127841983 0.00574061433187209 no 96 0.00638749122079167 99 1719405 SGTC_1264 0783-0040 158 µM 2.47852117584502 0.00592411949152005 no 97 0.00659641398352034 127 2855798 SGTC_376 3970-0862 59.1 µM 2.47688610392257 0.00595072079525151 no 98 0.00662670940053203 121 3135186 SGTC_337 1315-0038 354 µM 2.46778079746702 0.00610080285540237 no 99 0.00679767723411026 115 1626437 SGTC_361 000s-0510 1.45 µM 2.46762532506082 0.00610339435921535 no 100 0.00680063002425866 155 660 SGTC_1205 4161-2785 76 µM 2.45906069960978 0.00624766992381731 no 101 0.00696505316606299 134 3498106 SGTC_1899 st063254 59.6 µM 2.45379286233083 0.00633790201562636 no 102 0.0070679190658422 87 3093813 SGTC_2481 5478948 45.16 µM 2.44972215053988 0.00640841686152178 no 103 0.00714832440986061 159 77792 SGTC_1678 st019265 80.2 µM 2.44592257737016 0.00647486041209778 no 104 0.00722410114509032 143 5367020 SGTC_315 k915-0449 187 µM 2.44208297333027 0.00654262235634099 no 105 0.00730139498520316 177 20970215 YNL149C PGA2 SGTC_230 MPP+ 141.667 µM 2.43720679993525 0.00662958136862651 no 106 0.00740060597943503 121 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2035 5154463 94.595 µM 2.42668721544617 0.00682066958896539 no 107 0.00761869318108709 141 2769623 SGTC_3029 9088683 49.47 µM 2.41390136747739 0.00705946288902484 no 108 0.00789136707078167 133 25236615 SGTC_1338 1486-1223 76 µM 2.41170664080026 0.00710118612360525 no 109 0.00793902569717941 132 3444526 SGTC_2160 5660466 132.927 µM 2.40710138745719 0.00718944298916495 no 110 0.00803985256070746 107 2859134 SGTC_2922 7999257 32.47 µM 2.39604095185193 0.00740537251024219 no 111 0.0082866192681979 99 2988377 SGTC_3006 9075424 71.4286 µM 2.37934833702948 0.00774208017280838 no 112 0.0086716391070612 124 7465181 SGTC_2176 5809774 33.9695 µM 2.3722737853745 0.00788879928247855 no 113 0.00883949257819714 113 2870539 SGTC_2902 5787006 60.46 µM 2.37057271438774 0.00792444041607678 no 114 0.00888027500337325 133 591003 SGTC_998 3996-0085 177 µM 2.35538134508294 0.00824906324815746 no 115 0.00925185272637037 144 715391 SGTC_756 0508-1999 28.3 µM 2.34920499876925 0.00838434914879045 no 116 0.0094067727881107 125 6753853 SGTC_2446 5162541 200 µM 2.3481437842717 0.0084077889155148 no 117 0.00943361820903794 105 1549321 SGTC_419 nsc-638432 893 µM 2.34369547021304 0.00850666891066236 no 118 0.00954687708895005 129 368090 SGTC_2363 9053361 176 µM 2.34335942460341 0.00851418003771688 no 119 0.00955548126724244 159 6469797 YMR079W SEC14 SGTC_2008 4012253 172 µM 2.33174410312723 0.00877740220454867 no 120 0.00985707859013809 168 603940 SGTC_2204 7233102 200 µM 2.31804385071498 0.00909701903096921 no 121 0.0102234689973884 85 2172480 SGTC_1666 st014829 29 µM 2.30826116623577 0.00933143497770474 no 122 0.0104923074801349 150 3858230 SGTC_1913 st060213 96.1 µM 2.30360489124601 0.00944485467583733 no 123 0.0106224165177072 195 688959 SGTC_2172 5754775 163.918 µM 2.29436435656304 0.00967351495346302 no 124 0.0108847893697941 160 2263357 SGTC_432 NS 1619 61.3 µM 2.29161276601138 0.0097425321659264 no 125 0.0109639990839503 164 4552 A K+/calcium channel activator. SGTC_866 0495-0101 262 µM 2.2690377630534 0.0103252006085654 no 126 0.0116330147646378 144 635694 SGTC_2831 7999036 19.48 µM 2.2527845158349 0.0107633004064241 no 127 0.0121363694843892 212 2988270 SGTC_2274 7947094 46.08 µM 2.24185622552526 0.0110668886674077 no 128 0.0124853329888881 183 2971028 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.2297530801505 0.0114117806111418 no 129 0.0128819199333732 160 2333 A French combination drug. SGTC_2753 fluvastatin 17.09 µM 2.22627636010892 0.0115125641387197 no 130 0.0129978379604601 183 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_469 w7 172 µM 2.21548189275468 0.0118304169327291 no 131 0.0133635029228089 91 45115570 A P450 inhibitor. SGTC_957 1187-1561 14.1 µM 2.2153447985058 0.0118345022792822 no 132 0.0133682035782814 173 1538454 SGTC_1453 4237-0541 195 µM 2.20702470311523 0.0120847395614925 no 133 0.0136561667749789 163 739892 SGTC_261 5-fluorouridine 15.376 µM 2.20049955326308 0.0122841888162205 no 134 0.0138857358001441 171 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_623 k072-0108 16.9 µM 2.19682504849726 0.0123977550086187 no 135 0.0140164717072522 175 5382803 SGTC_1336 1486-0901 104 µM 2.19367127339334 0.0124959513181508 no 136 0.014129525219397 169 5006114 SGTC_3027 9089541 49.47 µM 2.18663459870345 0.0127174764520844 no 137 0.0143846047422008 183 9943819 SGTC_3114 9122766 49.47 µM 2.18612424091572 0.0127336746410704 no 138 0.0144032584707525 175 17176985 SGTC_2133 5320837 200 µM 2.17635738134347 0.0130471213499855 no 139 0.0147642739810222 168 2841355 SGTC_2031 5180455 200 µM 2.17591969794956 0.0130613226642443 no 140 0.014780632811285 138 29949 SGTC_2954 9074818 52.69 µM 2.15195480435872 0.0138595678410342 no 141 0.015700457084941 185 16648742 SGTC_3179 9107801 49.47 µM 2.14560067133531 0.0140781453345772 no 142 0.0159524259223262 155 4818259 SGTC_212 3807-4682 38.772 µM 2.12472302941079 0.014817362308656 no 143 0.0168048653353999 295 3125501 YBL034C STU1 SGTC_2983 9022671 12.99 µM 2.11586537955774 0.0151409315427228 no 144 0.0171781293160686 170 6405161 SGTC_2505 galangin 7.89 µM 2.11400580483433 0.0152096274083281 no 145 0.0172573857650698 134 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_731 3966-0296 387 µM 2.10585290759366 0.0155139784822357 no 146 0.017608565695829 184 660956 SGTC_1910 st062352 60.4 µM 2.10490824384852 0.0155495788285431 no 147 0.0176496479784607 232 2245730 SGTC_1246 0422-0085 105 µM 2.10400817405345 0.0155835638215564 no 148 0.0176888669938765 235 264295 SGTC_323 4013-0906 34.3 µM 2.08127963505327 0.0164631251897404 no 149 0.0187041590406847 151 2910086 SGTC_188 3229-0966 278.469 µM 2.07929942260143 0.016541730898302 no 150 0.0187949190865664 236 5722370 SGTC_1871 st057448 67.3 µM 2.07670374103169 0.0166452543666508 no 151 0.0189144555573542 210 691747 SGTC_1792 st045773 43.6 µM 2.07055159235619 0.0168928366172414 no 152 0.0192003599600891 213 2919270 SGTC_1829 berberine 14.4 µM 2.06721086200653 0.0170285928078792 no 153 0.0193571445705805 177 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2309 7664088 163.95 µM 2.06032474903979 0.017311365997751 no 154 0.0196837527347137 258 704922 SGTC_1275 0867-0008 21.1 µM 2.04956404727515 0.0177612744210504 no 155 0.0202034959262979 208 3422836 SGTC_680 0417-1641 114 µM 2.04820698211423 0.0178187159665281 no 156 0.0202698613015263 186 2835990 SGTC_1944 st076371 56.9 µM 2.04129984814214 0.0181135414548473 no 157 0.020610516082268 218 24208455 SGTC_995 3931-2021 34.6 µM 2.03949397502455 0.0181913058982908 no 158 0.0207003759645554 199 730143 SGTC_865 0488-0499 301 µM 2.03678154809871 0.0183086428535918 no 159 0.0208359690963599 191 9634651 SGTC_2594 a-mangostin 100 µM 2.03514993049374 0.0183795351700627 no 160 0.0209178946348284 236 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1447 4239-0816 81.9 µM 2.03464524506514 0.0184015105907241 no 161 0.0209432906613412 217 1341554 SGTC_2451 5856223 45.7 µM 2.03331474404423 0.0184595516383646 no 162 0.0210103672611311 210 2179896 SGTC_2185 6113692 200 µM 2.03266146694755 0.0184881068626682 no 163 0.0210433684170041 188 874150 SGTC_3274 9138298 49.47 µM 2.03018179760829 0.0185968376524595 no 164 0.0211690316837227 209 17015756 SGTC_3044 9093193 49.47 µM 2.02882650327802 0.0186564955784478 no 165 0.0212379824063615 247 25236277 SGTC_2289 7946404 165.07 µM 2.02036202400452 0.0190327862513612 no 166 0.0216729247719489 313 1246120 YPR165W RHO1 SGTC_377 3970-0964 33.1 µM 2.0198774767698 0.0190545208511198 no 167 0.0216980490469994 319 16481235 SGTC_2698 st077697 67.5 µM 2.0186328593096 0.0191104455194143 no 168 0.021762696547949 195 3154499 SGTC_2331 7980721 200 µM 2.01723557404744 0.0191733962644213 no 169 0.0218354676553413 235 2981221 SGTC_1722 st034304 3.6505 µM 2.00912308755734 0.0195423744369595 no 170 0.0222620408738121 244 4036148 YLR033W RSC58 SGTC_2077 5212015 200 µM 2.00838576713919 0.0195762067778749 no 171 0.0223011570822282 254 780900 SGTC_485 niflumic acid 177 µM 2.003900611491 0.0197830838805511 no 172 0.0225403540228705 187 4488 A COX2 inhibitor. SGTC_1396 3511-0007 98.6 µM 2.00198098630046 0.019872191720428 no 173 0.0226433882504872 189 X1396 SGTC_1380 2291-0730 164 µM 2.00094072358671 0.0199206222244405 no 174 0.0226993891299334 216 2999191 SGTC_3315 9136395 68.55 µM 1.99312932526107 0.0202874992230939 no 175 0.0231236437904088 208 16876844 SGTC_1017 4239-0030 168 µM 1.98525613732143 0.0206630583822214 no 176 0.0235579907136093 259 1149593 SGTC_103 0844-0104 51.839 µM 1.97291392025364 0.0212636382552665 no 177 0.024252685192715 391 5375804 SGTC_181 1447-1644 8.07 µM 1.96153470453928 0.0218303736009179 no 178 0.0249083403597171 235 534600 SGTC_380 3970-0968 6 µM 1.95711914105259 0.0220536980336191 no 179 0.0251667312489415 218 2891601 SGTC_1260 0700-1617 7.75 µM 1.95435684004835 0.0221943842086868 no 180 0.0253295155681618 274 2853078 SGTC_2681 menadione 3.18 µM 1.94636342012264 0.0226057686588452 no 181 0.0258055501897217 233 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_836 0330-0104 1.35 µM 1.94634340575665 0.0226068067193847 no 182 0.0258067514436822 220 46494820 SGTC_2138 5575593 77.673 µM 1.94587003653247 0.022631370096869 no 183 0.0258351765134067 191 762213 SGTC_370 0180-0345 38.7 µM 1.94211748542362 0.022826889173398 no 184 0.0260614395971017 204 3989527 SGTC_18 0111-0177 500 nM 1.93869574454266 0.0230064107521665 no 185 0.0262691985713417 346 721752 SGTC_3124 9127567 49.47 µM 1.93046016924242 0.0234433704637181 no 186 0.0267749229336299 209 17592030 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.9296231606049 0.0234881684693699 no 187 0.0268267734825972 288 65057 A dermal irritant. YDR527W RBA50 SGTC_631 k072-0230 41.5 µM 1.92919602700162 0.0235110570642262 no 188 0.0268532656110591 248 5773147 SGTC_1166 k206-0078 225 µM 1.92769791372548 0.0235914840790647 no 189 0.0269463558786601 273 5404595 SGTC_691 1548-0686 185 µM 1.92667983015951 0.023646272402533 no 190 0.027009771510628 284 46495133 SGTC_1920 st075728 45.7 µM 1.9245123198858 0.023763273783733 no 191 0.0271451989945891 249 3400306 SGTC_2108 5365811 200 µM 1.92021489796417 0.0239966864653032 no 192 0.0274153802870559 254 780283 SGTC_2280 7785178 200 µM 1.92001491835493 0.0240075950215813 no 193 0.0274280075253308 207 2954328 SGTC_1490 4089-0339 670 nM 1.9166395807904 0.0241923436838996 no 194 0.0276418679622176 164 742542 SGTC_1039 k821-0043 94 µM 1.91385825745534 0.024345475099233 no 195 0.0278191346357617 247 15992768 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.91285180910647 0.0244010873204588 no 196 0.0278835132025338 262 4174840 SGTC_2600 tangeritin 87.95 µM 1.90800402503804 0.0246704522190537 no 197 0.0281953480256982 229 68077 A bioactive flavone. SGTC_290 2043-6722 48.1 µM 1.90791672345611 0.0246753258684517 no 198 0.0282009902234169 226 773758 YLR208W SEC13 SGTC_988 1497-1057 103 µM 1.90149797194872 0.0250358750372174 no 199 0.0286184089449552 253 3533044 SGTC_2419 paclitaxel 166.5 µM 1.8976813371719 0.0252523463927484 no 200 0.0288690362479389 337 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3313 9133968 57.047 µM 1.89147639411758 0.0256076239594053 no 201 0.0292803896079919 262 1494643 SGTC_2017 5132927 60.65 µM 1.8852369571358 0.0259690867922238 no 202 0.0296989266476446 285 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1229 0139-0193 12.2 µM 1.88063128026524 0.0262386325036548 no 203 0.0300110467923212 273 3090752 SGTC_2080 5212524 12.4 µM 1.88037829263404 0.0262535060413259 no 204 0.0300282699171329 210 260183 SGTC_1046 2001-0062 216 µM 1.86677353824402 0.0270637949387743 no 205 0.0309666096468706 265 739778 SGTC_321 4534-3890 65.3 µM 1.86373499786647 0.027247591271097 no 206 0.0311794640159031 212 699746 SGTC_1136 pergolide 1.05886 µM 1.86049054204811 0.02744499137753 no 207 0.031408077670641 368 47811 A dopamine receptor agonist. SGTC_1253 0550-0034 176 µM 1.86005072541059 0.0274718423818285 no 208 0.0314391748145238 262 5969915 SGTC_463 ikarugamyin 104 µM 1.85685855649335 0.027667382838025 no 209 0.0316656400751683 157 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2908 7930301 100 µM 1.85411692926882 0.0278362494502047 no 210 0.031861216603196 307 2223178 SGTC_71 0417-1750 47.813 µM 1.85093408193511 0.0280333685721803 no 211 0.0320895184360904 309 6811472 SGTC_1676 st018489 23.4 µM 1.84177471933299 0.028607118827382 no 212 0.0327540547144476 300 3696235 SGTC_149 3970-0822 46.1 µM 1.837980970194 0.0288476063595352 no 213 0.0330326047441693 441 3114250 YBL034C STU1 SGTC_980 1473-0395 201 µM 1.81465845479683 0.0303632214707766 no 214 0.0347882066585238 210 768876 SGTC_724 3910-0327 137 µM 1.81303318175198 0.0304712544664127 no 215 0.0349133518382115 287 2885483 SGTC_421 streptovitacin 30 mM 1.81194015828743 0.0305440874088278 no 216 0.0349977217271675 315 91467 include heat shock SGTC_1406 3909-7906 11.9 µM 1.8096418739723 0.0306977025766576 no 217 0.0351756709224752 278 X1406 SGTC_1618 st003135 44.5 µM 1.80861673451243 0.0307664279540275 no 218 0.0352552834202154 238 1270615 SGTC_270 tamoxifen 5.46 µM 1.80770804091658 0.0308274532515237 no 219 0.0353259762318678 307 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2106 5357045 167.29 µM 1.79626374904828 0.0316046330793529 no 220 0.0362262901539064 289 668842 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.78924289078373 0.032089382684995 no 221 0.0367878534700674 329 5379071 SGTC_1223 0764-0573 147 µM 1.7876711613776 0.0321987382544076 no 222 0.0369145385410457 327 1609797 SGTC_3075 9116269 49.47 µM 1.78629002455814 0.0322950867913647 no 223 0.037026155616326 263 17015205 YNL244C SUI1 SGTC_1027 k015-0025 8.67 µM 1.78396529588072 0.0324577978108794 no 224 0.0372146522580387 302 3598955 SGTC_2558 carylophyllene oxide 100 µM 1.78202692737823 0.0325939834530629 no 225 0.0373724203466294 294 6708694 An oxygenated terpenoid and antifungal agent. SGTC_400 oxethazaine 37.5 µM 1.77823243832635 0.0328619404768167 no 226 0.0376828436831695 280 4621 A local anesthetic. SGTC_831 k061-1017 217 µM 1.77420201342524 0.033148544733201 no 227 0.0380148706504996 461 1240153 SGTC_8 0354-0001 70 µM 1.77393001029185 0.0331679608719057 no 228 0.0380373640059492 409 4993152 SGTC_1154 4088-0362 150 µM 1.76358317294024 0.0339135240387842 no 229 0.0389010914003231 359 6618304 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.74938744321738 0.0349588039851028 no 230 0.0401120349542602 336 6708784 An antioxidant flavonoid SGTC_258 haloperidol 50.781 µM 1.74509707933608 0.0352798725261791 no 231 0.0404839859488458 349 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1173 0443-0020 122 µM 1.74427658775764 0.0353415485230293 no 232 0.0405554360340655 329 5331295 SGTC_580 1123-0028 41 µM 1.73643780302302 0.0359352559329423 no 233 0.0412432264547159 375 1677248 YPR107C YTH1 SGTC_2236 dapsone 200 µM 1.73463462051548 0.036072978082926 no 234 0.0414027716456218 307 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1613 st002381 52.1 µM 1.73429991767966 0.036098589273493 no 235 0.0414324410453731 314 551167 SGTC_2952 9073731 13.78 µM 1.73384795099185 0.0361331970272296 no 236 0.0414725325219122 366 16457353 SGTC_1695 st026914 34.495 µM 1.72499195860816 0.0368168124698498 no 237 0.0422644608533045 309 3289191 SGTC_2625 euphol 100 µM 1.72465960969878 0.0368426717859237 no 238 0.0422944170088846 355 6708538 A triterpene alcohol. SGTC_1807 st050092 58.9 µM 1.72282983027329 0.0369853088771132 no 239 0.0424596513173704 295 5008496 SGTC_541 4513-1321 94 µM 1.72216125325178 0.037037539043754 no 240 0.0425201558125675 316 747515 SGTC_692 k241-0027 77.8 µM 1.71338639291255 0.0377286479812898 no 241 0.0433207389661309 304 3600480 SGTC_920 mycophenolic acid 780.421 nM 1.71077806432149 0.0379360979369681 no 242 0.0435610452143349 327 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2028 5153890 36.43 µM 1.70998205538337 0.0379995924871952 no 243 0.0436345956931903 318 2830968 YPR165W RHO1 SGTC_1440 4100-1550 40 µM 1.70918737618022 0.0380630674248513 no 244 0.0437081232370449 247 742806 SGTC_2174 5790901 200 µM 1.70827199022985 0.0381362909698615 no 245 0.0437929430152131 338 786020 SGTC_1372 2752-0194 270 µM 1.70721975700103 0.0382206030933824 no 246 0.043890607076124 302 823334 SGTC_2283 7944793 200 µM 1.70180228246108 0.0386570971895144 no 247 0.04439621925091 344 2970533 SGTC_87 0100-0052 35.5 µM 1.7016655440039 0.0386681667464611 no 248 0.0444090415060262 561 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1701 st028638 40.4 µM 1.69818001661855 0.0389512079752745 no 249 0.0447368954890996 327 3490878 SGTC_2260 7964312 200 µM 1.69777790101096 0.0389839699213862 no 250 0.0447748441734603 284 231951 SGTC_810 3825-7150 143 µM 1.69561932585341 0.0391602212604981 no 251 0.0449789977165353 316 22330411 YGL099W LSG1 SGTC_2109 5483026 200 µM 1.69527697872878 0.0391882339865745 no 252 0.0450114449266317 370 759335 SGTC_1040 k898-0338 155 µM 1.69071388018305 0.0395631716159954 no 253 0.0454457310126065 370 20969351 SGTC_890 0929-0006 47.2 µM 1.68501312776512 0.0400356810797983 no 254 0.0459930193642486 290 1378169 SGTC_1078 idebenone 36.1 µM 1.68218032071531 0.0402721794036444 no 255 0.0462669394770302 399 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3183 9108214 49.47 µM 1.68147627560989 0.0403311326732631 no 256 0.0463352204205763 179 4974831 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.67732923395568 0.0406798092103724 no 257 0.0467390594956108 338 165521 SGTC_150 3970-0969 77.2 µM 1.67502999104824 0.040874177555964 no 258 0.0469641737331513 428 6615640 SGTC_2083 5306046 65.942 µM 1.67491553129482 0.0408838731556694 no 259 0.0469754029368196 367 539837 SGTC_2258 7960471 200 µM 1.67474958645796 0.0408979332413747 no 260 0.0469916869663457 255 2974708 SGTC_2064 5220758 200 µM 1.66169832344346 0.0420160778975425 no 261 0.0482866387358034 388 788518 SGTC_168 3970-0862 530.542 µM 1.65853190925225 0.0422910522537872 no 262 0.0486050762147361 571 3135186 SGTC_1334 1486-0610 236 µM 1.65357735475846 0.0427242300427458 no 263 0.049106708478656 361 3742339 SGTC_2623 humulene 100 µM 1.65269575042313 0.0428016834960001 no 264 0.049196399857021 287 6187145 An anti-inflammatory. SGTC_1802 st050112 57.9 µM 1.65182001079142 0.0428787340253911 no 265 0.049285624056085 328 4662563 SGTC_2005 4024620 188 µM 1.64678250310259 0.0433241304123824 no 266 0.0498013794963394 322 236743 SGTC_2349 9023730 187.07 µM 1.64645165795774 0.0433535126686707 no 267 0.0498354025381433 370 4126287 SGTC_2827 7993847 71.43 µM 1.64372051670081 0.0435966795561534 no 268 0.0501169729996057 289 2985692 SGTC_1466 k213-0079 57.5 µM 1.6426572604214 0.0436916436426156 no 269 0.0502269331603469 350 3657981 SGTC_2560 caryophyllene 100 µM 1.63951829744036 0.0439729722554597 no 270 0.050552681583842 386 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_26 0302-0163 425.158 µM 1.62787889398267 0.0450289250546543 no 271 0.0517752837722507 318 3100915 SGTC_214 4373-3496 70 µM 1.62684753247111 0.0451234685308958 no 272 0.0518847417915332 505 3779166 SGTC_2782 7736369 71.43 µM 1.62385496919205 0.0453986970722747 no 273 0.0522033825496868 397 2950836 YOL077C BRX1 SGTC_2059 5238311 157 µM 1.61595969551605 0.0461313156618075 no 274 0.0530515137938794 343 703021 SGTC_1919 st067113 52.3 µM 1.60918696992674 0.0467673103186313 no 275 0.0537877323543678 392 1268243 SGTC_1183 1254-0324 198 µM 1.60681500017824 0.0469917068669911 no 276 0.0540474783623073 354 5799357 SGTC_2721 ifenprodil 61.44 µM 1.60539562932111 0.047126396632704 no 277 0.0542033828330138 359 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_169 k015-0017 16.025 µM 1.6045712508131 0.0472047671688502 no 278 0.0542940962586666 331 1840002 SGTC_1312 1218-2183 165 µM 1.60184160437323 0.0474650101740265 no 279 0.0545953201761678 370 6744073 SGTC_115 0527-0192 112.043 µM 1.60068915577375 0.0475752285316935 no 280 0.0547228921006786 484 4233931 SGTC_2502 avocadyne acetate 18.59 µM 1.59509223438533 0.0481134278372235 no 281 0.0553458058910031 446 3952079 SGTC_481 bay k-8644 50 µM 1.59102828987808 0.048507260923125 no 282 0.0558016046345066 362 2303 A calcium channel antagonist. SGTC_1640 st009078 66.4 µM 1.57625262452554 0.0499609243026668 no 283 0.0574837975168061 314 690618 SGTC_2187 6125751 200 µM 1.57065073875191 0.0505210506624548 no 284 0.0581318987216711 383 874498 SGTC_2607 solasodine 47.35 µM 1.56335456859814 0.0512580750597403 no 285 0.0589846098956434 430 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3007 9078383 71.4286 µM 1.56294426045975 0.0512997751599982 no 286 0.0590328529499547 387 6496995 SGTC_104 0074-0074 590.992 µM 1.56169339319433 0.0514270688423161 no 287 0.059180117982285 241 3943124 SGTC_2882 9058044 58.44 µM 1.56046618736209 0.0515521986418544 no 288 0.0593248771840151 363 18076804 SGTC_1460 k062-0059 9.15 µM 1.55943345029116 0.0516576872709285 no 289 0.0594469121632885 357 1373085 SGTC_1662 st014054 52 µM 1.55851433927175 0.0517517138566712 no 290 0.0595556857607394 321 2838777 SGTC_2398 5228213 48.84 µM 1.55332525972543 0.0522851200066637 no 291 0.0601727242842415 485 80771 YMR134W ERG29 SGTC_2682 pyrogallin 40.03 µM 1.54850406353314 0.0527846136711485 no 292 0.0607504920698586 431 822798 An ATP competetive kinase inhibitor. SGTC_2259 7964009 200 µM 1.54047729440839 0.0536246068581733 no 293 0.0617220266208342 366 313134 SGTC_1961 st076550 68.7 µM 1.53651391674914 0.05404325746956 no 294 0.0622061936177984 356 1579337 SGTC_187 1488-2104 32.728 µM 1.53438722659822 0.054268963429726 no 295 0.0624672090738017 417 2852859 SGTC_618 k072-0232 33.2 µM 1.53075558744078 0.0546561134492514 no 296 0.0629149048957938 367 5872756 YGL099W LSG1 SGTC_854 0422-0053 192 µM 1.52852438371787 0.05489505125897 no 297 0.0631911970973134 399 3596728 SGTC_1663 st014140 55.4 µM 1.51619400488785 0.0562304222303684 no 298 0.0647351517731875 465 4207120 SGTC_1693 xanthone 101.9 µM 1.51581514392403 0.0562718545884205 no 299 0.0647830508306695 423 7020 An insecticide. SGTC_2608 thymoquinone 42.66 µM 1.51083463713853 0.0568187651020139 no 300 0.0654152937062253 359 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_185 k048-0037 25.491 µM 1.50910228549251 0.0570099733240275 no 301 0.0656363228018276 415 6827589 SGTC_1721 st082152 9.2685 µM 1.50420687296356 0.057553043481361 no 302 0.0662640543169667 385 5296051 SGTC_2807 7945238 51.95 µM 1.49944967834051 0.0580846707198492 no 303 0.0668785070302197 451 17148797 SGTC_379 3970-0972 5.9 µM 1.4946301058779 0.0586271962042351 no 304 0.0675055022716229 426 2898042 YBL034C STU1 SGTC_1500 4488-1866 171 µM 1.4937527098166 0.0587263888248013 no 305 0.0676201330137662 474 2900003 SGTC_850 0388-0143 75.9 µM 1.4933393499043 0.0587731661994204 no 306 0.0676741900802726 404 67273 SGTC_1972 st070201 17.4 µM 1.49322742864921 0.0587858366623308 no 307 0.0676888323037168 413 2829099 SGTC_653 0203-0016 55.2 µM 1.48699562226533 0.0594947203306058 no 308 0.0685079835850472 438 295302 SGTC_2690 usnic acid 100 µM 1.48623105411053 0.0595821513903986 no 309 0.0686090080847294 512 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1795 st049545 62.3 µM 1.47914970967101 0.0603967206027175 no 310 0.0695501534880269 417 5291882 SGTC_176 1486-1328 72.834 µM 1.47653179915773 0.0607000566663194 no 311 0.0699005925817747 477 22310231 SGTC_1411 3909-8223 150 µM 1.47216140442333 0.0612091057293057 no 312 0.0704886485115393 437 X1411 SGTC_1638 st008370 60.6 µM 1.47131168833369 0.0613084640824104 no 313 0.0706034218888926 464 24207134 SGTC_3055 9094636 49.47 µM 1.47093957516817 0.0613520153899236 no 314 0.0706537293892125 400 25236176 SGTC_251 melphalan 456.522 µM 1.4704235556621 0.0614124491714384 no 315 0.0707235377589948 509 460612 A DNA alkylator. SGTC_2684 capsaicin 100 µM 1.46797903536488 0.0616993720463099 no 316 0.0710549588407152 411 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3056 9094900 49.47 µM 1.46686305247047 0.0618307067836013 no 317 0.0712066565948835 442 25236784 SGTC_2151 5563267 85.4165 µM 1.46604985083918 0.0619265459929227 no 318 0.0713173532168406 458 5310824 SGTC_95 0471-0001 561.058 µM 1.46567208343857 0.0619711068787602 no 319 0.0713688215099379 454 4015405 SGTC_2004 4023728 41.89 µM 1.46378811091933 0.0621937111689282 no 320 0.0716259259479767 469 360084 YDR527W RBA50 SGTC_2122 5258151 111.688 µM 1.46072142262879 0.0625573948543952 no 321 0.0720459537636735 444 2173356 SGTC_893 0958-0369 48.9 µM 1.45773388277028 0.0629132843391186 no 322 0.0724569543962043 483 6819948 SGTC_2903 5923464 63.88 µM 1.45522955482655 0.0632128249937416 no 323 0.0728028607043944 407 2876576 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.45470227072083 0.063276034314542 no 324 0.0728758518455239 415 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2478 5763493 32.33 µM 1.44987340211736 0.0638571965389478 no 325 0.0735469128443146 452 1365576 YLR208W SEC13 SGTC_2773 thioridazine 9.09 µM 1.4439569694185 0.0645748983368746 no 326 0.0743755399534958 457 5452 An antipsychotic. SGTC_2641 levomentholum 100 µM 1.44213036068015 0.0647977391220163 no 327 0.07463280078681 373 16666 SGTC_1486 3970-0793 4.53 µM 1.43822828111827 0.0652757809531973 no 328 0.0751846466760115 451 2844330 SGTC_790 1575-0012 79.1 µM 1.42941987927903 0.0663649500400174 no 329 0.0764417940358842 469 378741 YLR208W SEC13 SGTC_2265 7929201 200 µM 1.42820161034469 0.0665166917366327 no 330 0.0766169186292707 468 1265108 SGTC_2636 apigenin dimethyl ether 100 µM 1.42665976456413 0.0667091214998429 no 331 0.0768389942421289 507 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2422 chlorphenesin carbamate 384.24 µM 1.42122348852124 0.0673910334022425 no 332 0.0776258991470701 518 2724 A muscle relaxant with antifungal properties. SGTC_1506 4226-2149 212 µM 1.41642660982444 0.0679972044216874 no 333 0.0783253187775732 525 991114 SGTC_765 1319-0117 244 µM 1.4138457895549 0.0683250742232487 no 334 0.0787035928811329 419 3487746 YGL099W LSG1 SGTC_579 4491-1009 110 µM 1.38941748257086 0.071489169441957 no 335 0.0823529185764173 616 1271041 SGTC_1152 3909-8331 15.9 µM 1.38827772965792 0.0716394973107627 no 336 0.0825262454848398 460 16001939 SGTC_69 0096-0274 206.684 µM 1.38703000038978 0.0718043446760928 no 337 0.0827163075153206 559 6741392 SGTC_2797 7859098 81.82 µM 1.38699593218725 0.0718088497721608 no 338 0.0827215016157817 507 972681 SGTC_1248 0469-0687 58.6 µM 1.38099820087046 0.0726053587491679 no 339 0.0836397569205111 503 4017482 SGTC_1131 3454-3128 32.3 µM 1.37888056983863 0.0728881943647665 no 340 0.0839657899152747 549 710982 SGTC_2011 4012611 177 µM 1.3751478503161 0.0733887974945056 no 341 0.0845428060684239 512 2049887 SGTC_179 1273-0063 6.77 µM 1.37267938318782 0.0737212907477857 no 342 0.0849260206203551 435 3108139 SGTC_1103 duloxetine 36.1 µM 1.36973488305472 0.0741194084215495 no 343 0.0853848377092048 560 60835 A selective serotonin reuptake inhibitor. SGTC_56 0957-0365 83.25 µM 1.36861949716635 0.074270644792271 no 344 0.0855591231004945 516 6752360 SGTC_2321 7390090 138.78 µM 1.36828860988996 0.074315555448179 no 345 0.0856108773210332 436 649046 SGTC_2156 5649887 115 µM 1.36664864530319 0.0745384506472364 no 346 0.0858677309197314 577 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_281 1672-3440 14.9 µM 1.36621763406933 0.0745971159820149 no 347 0.0859353321285819 531 6833000 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.36153037429405 0.0752373806324394 no 348 0.0866730707022268 393 279621 SGTC_2150 5556613 200 µM 1.35453674261655 0.0762004657624265 no 349 0.0877825996889812 550 743190 SGTC_3321 9137793 26.8275 µM 1.35123754856329 0.0766580385531083 no 350 0.0883096750405119 536 4904192 SGTC_535 2293-4129 48.2 µM 1.3491210944822 0.0769526727560191 no 351 0.0886490368708515 609 396118 YIL048W NEO1 SGTC_2312 7706453 155.7 µM 1.34432789927864 0.0776231206178204 no 352 0.0894211888042513 513 976098 SGTC_598 3937-0236 20.2 µM 1.33624178187052 0.0787642038313147 no 353 0.0907351292556801 583 1379313 SGTC_3120 9124077 49.47 µM 1.3329043176646 0.0792388630469244 no 354 0.0912816027439349 520 18774327 YGL155W CDC43 SGTC_3 0833-0587 95.581 µM 1.3311330119962 0.0794916589228465 no 355 0.0915726241793496 513 5382644 SGTC_952 1185-0122 232 µM 1.33015556942408 0.0796314179096603 no 356 0.0917335098389164 530 678600 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.32851502826986 0.0798664073598847 no 357 0.0920040111169316 546 3256 An antibiotic and ribosome inhibitor. SGTC_3122 9126309 49.47 µM 1.32761602321075 0.0799954021707015 no 358 0.0921524942150123 484 17591206 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.32387924231142 0.0805332672388587 no 359 0.0927715765720525 494 2346 DNA damaging agent; causes G2/M arrest. SGTC_2240 6690706 185.951 µM 1.3147694297418 0.0818559588804128 no 360 0.0942937022235068 444 805876 SGTC_1051 3253-3903 78 µM 1.31305905175601 0.0821061110782102 no 361 0.0945815252813123 557 5509239 SGTC_307 1501-1223 22.3 µM 1.31081737545232 0.0824348400438414 no 362 0.0949597353938537 539 2830329 SGTC_1744 st037937 38.9 µM 1.30572850585245 0.083184770258575 no 363 0.0958224502214132 541 1016152 SGTC_2761 levamisole 97.89 µM 1.29298295347027 0.085085540570414 no 364 0.0980084774546035 543 26879 An alkaline phosphatase inhibitor. SGTC_1388 3346-4487 254 µM 1.29055924111434 0.0854506484525319 no 365 0.0984282785520789 599 3345614 SGTC_1435 4092-0789 56.7 µM 1.29004545239436 0.0855281960700869 no 366 0.0985174386432808 560 2248285 SGTC_2508 celastrol 40.54 µM 1.28880076828269 0.0857162783114227 no 367 0.0987336794390461 485 122724 Celastrol is a natural product and antioxidant. SGTC_2680 butyl paraben 22.24 µM 1.28743359273462 0.0859232266926101 no 368 0.0989716009491367 495 7184 An antifungal and steroid mimetic. SGTC_1437 4092-1038 11.6 µM 1.28196205022754 0.0867551936121944 no 369 0.0999279795699802 585 3977136 SGTC_91 0417-1751 58.384 µM 1.2793738801915 0.087150824687167 no 370 0.100382713637946 687 6795624 SGTC_841 0251-0215 91.2 µM 1.27734415355231 0.0874620327889972 no 371 0.100740385897191 620 3888614 SGTC_160 3453-0671 289.699 µM 1.27506766056329 0.087812062340211 no 372 0.101142647334578 572 5322268 SGTC_123 0083-0120 66.675 µM 1.27481829847717 0.087850467221536 no 373 0.101186781211391 590 16001701 SGTC_2644 guaiazulene 100 µM 1.27297353857611 0.0881349725631127 no 374 0.101513715945981 532 3515 A coloring agent. SGTC_1526 st051518 75 µM 1.27004769152188 0.0885876147071467 no 375 0.102033821288915 520 673993 SGTC_3269 9137823 49.47 µM 1.26948532323546 0.0886748137483935 no 376 0.102134010943173 510 17682936 SGTC_3076 9116187 49.47 µM 1.26908843593671 0.0887363923000144 no 377 0.102204762124784 520 27241210 SGTC_409 arachidonic acid 100 µM 1.26854854999739 0.088820208741828 no 378 0.102301062208095 580 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_482 fipronil 114 µM 1.26807561376064 0.0888936797727364 no 379 0.102385474605317 494 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3232 9132874 49.47 µM 1.26796805047017 0.0889103961316762 no 380 0.102404680191939 536 3784940 SGTC_1074 carmofur 3.8 µM 1.26794415932538 0.0889141093605393 no 381 0.102408946347156 621 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3086 9117350 49.47 µM 1.26713461510515 0.0890399992434262 no 382 0.102553580118494 458 2679265 SGTC_2571 chrysanthemic acid 100 µM 1.26479565764841 0.0894044690985926 no 383 0.102972294206166 532 2743 An insecticide. SGTC_3155 9099265 49.47 µM 1.26449713897444 0.0894510657421698 no 384 0.103025823481293 518 25236499 SGTC_6 0844-0013 19.835 µM 1.25910880739558 0.090295254261626 no 385 0.103995516831261 812 1584900 SGTC_2131 toluylene red 5.2905 µM 1.25872083114286 0.0903562659904665 no 386 0.104065592268932 563 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3351 9150312 21.596 µM 1.24989659179715 0.091752211991661 no 387 0.105668662301242 588 4904905 SGTC_1960 st011366 51.8 µM 1.24949314004218 0.0918164156500862 no 388 0.105742380504195 568 3972846 SGTC_2567 aureobasidin a 60 nM 1.24921355099483 0.0918609278226029 no 389 0.105793488472198 594 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3000 9075062 71.4286 µM 1.24605431450389 0.092365007431534 no 390 0.106372227787636 558 17057871 SGTC_2395 5646831 180.19 µM 1.24533793598249 0.0924795951125727 no 391 0.106503778279809 579 6808628 SGTC_2603 homopterocarpin 100 µM 1.245215901308 0.0924991255390948 no 392 0.106526199534668 608 101795 A weak amylase inhibitor. SGTC_3050 9093513 49.47 µM 1.24222306324911 0.0929790548230996 no 393 0.107077136275894 579 25236664 SGTC_3326 9140064 16.379 µM 1.24035873640869 0.0932789459185546 no 394 0.107421368093762 558 1868434 SGTC_1606 st000094 49.2 µM 1.23960263572778 0.0934007739206015 no 395 0.107561202648485 616 1242210 SGTC_2940 9060638 45.86 µM 1.23927564193615 0.0934534977408995 no 396 0.107621718053721 594 4027022 SGTC_2048 5246248 200 µM 1.23731421958756 0.0937702150031222 no 397 0.107985225419993 547 677046 SGTC_713 1488-1073 324 µM 1.23526495744111 0.0941019617051036 no 398 0.108365955496982 583 3312542 SGTC_2479 5617353 43.85 µM 1.23480010909584 0.0941773344545501 no 399 0.108452453385685 595 2731746 SGTC_3202 9113761 49.47 µM 1.23015883543287 0.0949323364219917 no 400 0.109318815712013 659 4798415 SGTC_2833 9001315 45.46 µM 1.23000473160229 0.0949574809559207 no 401 0.109347666504737 615 2989378 SGTC_2015 5119600 184 µM 1.2278428571897 0.0953107431091967 no 402 0.109752981944647 618 2828786 SGTC_1315 1237-0019 3.69 µM 1.22548670944724 0.0956968514502707 no 403 0.110195947312263 622 825140 SGTC_3246 9135460 32.98 µM 1.22202871430895 0.096265604593226 no 404 0.110848384262364 513 41446951 SGTC_2270 7924575 90.91 µM 1.22046548742396 0.096523529963395 no 405 0.111144232542549 646 1262135 SGTC_1476 4112-3294 3.34 µM 1.21723786699183 0.0970576784016546 no 406 0.111756863304451 589 704369 SGTC_1313 1220-0047 237 µM 1.21614916473113 0.0972383394011111 no 407 0.111964052344642 661 3528706 SGTC_671 0560-0003 407 µM 1.21457611882714 0.0974998088113848 no 408 0.112263900868165 569 3238678 SGTC_84 0443-0269 128.823 µM 1.21061048843067 0.098161258028486 no 409 0.113022361296689 629 6150058 SGTC_740 k014-0057 261 µM 1.210039754345 0.0982567238548631 no 410 0.113131819352641 688 4012779 SGTC_1161 k007-0610 110 µM 1.20901533815693 0.0984282469457656 no 411 0.113328476373619 710 5843850 SGTC_1539 benzyladenosine 56 µM 1.20883088919431 0.09845915342983 no 412 0.1133639109019 587 92208 A nucleotide analog. SGTC_2810 7959871 45.46 µM 1.20736015898024 0.0987058449574408 no 413 0.113646735924366 660 2974535 SGTC_2191 5911152 200 µM 1.203744339376 0.0993142636259474 no 414 0.114344204481341 596 2875902 SGTC_2658 polymyxin b sulfate 77.05 µM 1.2027121927593 0.0994884405719088 no 415 0.114543856982857 647 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1105 epirubicin 18.1 µM 1.20212195355052 0.0995881449882576 no 416 0.11465814091191 601 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3102 9121669 49.47 µM 1.20142166937745 0.0997065331094327 no 417 0.114793837299597 571 41905072 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.20125321925545 0.0997350261604329 no 418 0.114826495478733 593 140250 A respiratory chain inhibitor. SGTC_2870 9038528 12.99 µM 1.19406565218422 0.100956338781463 no 419 0.116226143900222 557 6463316 SGTC_2516 gossypol 71.55 µM 1.1940360298128 0.100961394679692 no 420 0.116231937261348 675 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_395 anisomycin 6.25 µM 1.19003421628369 0.101646115601241 no 421 0.117016471958864 549 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1126 isoteolin 1.0172 µM 1.18782818163724 0.102025016675019 no 422 0.117450554523875 618 133323 SGTC_815 1582-0027 36.9 µM 1.18411637346047 0.102664861941746 no 423 0.118183499765527 632 3128206 SGTC_501 nsc-95397 161 µM 1.18206620282406 0.103019520361658 no 424 0.118589716702615 615 262093 SGTC_2311 7694451 200 µM 1.18137900984174 0.10313859658956 no 425 0.118726096343522 635 2163142 SGTC_1304 1165-0502 251 µM 1.17576497195414 0.104115137876098 no 426 0.119844403680099 688 767425 SGTC_2489 cantharidin 73.42 µM 1.17395128725523 0.104432049759186 no 427 0.120207268913238 646 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_599 1935-0052 86.5 µM 1.17305211904488 0.104589423677236 no 428 0.120387452900644 669 9557311 SGTC_1775 st081588 35.1725 µM 1.16559274308533 0.105901603770503 no 429 0.121889571638929 678 1426443 YGL099W LSG1 SGTC_2469 5655019 90.81 µM 1.16509182825691 0.105990144191315 no 430 0.121990912148934 682 2788239 SGTC_2700 st077718 96.8 µM 1.16311923798321 0.106339334264244 no 431 0.122390563880216 602 904970 SGTC_1948 st076329 66.6 µM 1.15939703808941 0.107000503531707 no 432 0.123147191773539 598 24208413 SGTC_1888 azatryptophan 97.5 µM 1.15294440498732 0.108153692237061 no 433 0.124466602163695 601 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1630 st005209 31.3 µM 1.15102354637619 0.108498702174907 no 434 0.124861274359106 749 3367314 SGTC_2032 5185112 25.99 µM 1.14619528070904 0.109369412998602 no 435 0.125857180076195 615 5718189 SGTC_1492 4158-0558 28.5 µM 1.14431943815255 0.109709045456137 no 436 0.126245592414823 645 3967268 SGTC_1562 morin hydrate 59.1 µM 1.14355892314281 0.1098469567111 no 437 0.12640330257165 636 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1164 k060-0068 93.7 µM 1.14275806478757 0.109992318252647 no 438 0.126569527174052 716 5963676 SGTC_1966 st070145 16.1 µM 1.14272476110753 0.109998366097424 no 439 0.12657644291701 654 3748532 SGTC_3178 9107506 49.47 µM 1.14214064989382 0.110104477671254 no 440 0.126697780502908 676 8897194 SGTC_907 3448-6986 75.5 µM 1.13796530361894 0.110865123848137 no 441 0.127567485320143 725 590582 SGTC_568 1193-0097 7.48 µM 1.13468677546875 0.111465024781636 no 442 0.128253290113282 685 3646150 SGTC_2433 5607874 27.82 µM 1.1284117284988 0.11261969579812 no 443 0.129573038420744 665 2252428 SGTC_1442 4112-3290 3 µM 1.12693464708751 0.112892731150269 no 444 0.129885056609257 704 704353 SGTC_2781 5567276 71.43 µM 1.12613730799428 0.113040313813057 no 445 0.130053702276424 648 2853274 SGTC_3264 9137442 49.47 µM 1.12565640957805 0.113129391750132 no 446 0.130155490626273 641 17015726 SGTC_644 1498-1197 63.3 µM 1.12285145406164 0.113649958357046 no 447 0.130750294103653 715 6741615 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.1225530140645 0.113705445641793 no 448 0.130813690068444 700 688664 SGTC_2923 7992654 58.14 µM 1.11893737427831 0.114379215936634 no 449 0.131583428540941 662 2985126 SGTC_2588 indole-3-carbinol 100 µM 1.11847421327062 0.114465730410744 no 450 0.131682256928303 735 3712 Induces cell cycle arrest. SGTC_1692 fluoroquinolonic acid 71 µM 1.11419260426486 0.115267704215092 no 451 0.132598283771406 678 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_3289 9119912 71.43 µM 1.11308959832998 0.115474950004583 no 452 0.132834975276657 678 17014829 SGTC_60 0986-0278 202 µM 1.11285395263697 0.115519260206142 no 453 0.132885579637588 552 3110598 SGTC_2002 4023503 131 µM 1.11161319896511 0.115752767559429 no 454 0.133152247518466 817 4736863 YCR052W RSC6 SGTC_3031 9088762 49.47 µM 1.11147422667837 0.115778942726976 no 455 0.133182138932751 703 205253 SGTC_664 1222-0054 14.9 µM 1.11062716666129 0.115938575777109 no 456 0.133364432099801 712 6813991 SGTC_2729 fluphenazine 10.66 µM 1.10967351458609 0.1161184836066 no 457 0.133569869936444 698 3372 An atypical antipsychotic. SGTC_1386 3228-0095 33.8 µM 1.1084896353945 0.116342099667607 no 458 0.133825206437278 681 870181 SGTC_449 xestospongin c 11.1929 µM 1.10795066560512 0.116444003682149 no 459 0.133941561341391 728 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_527 4476-4215 268 µM 1.10722922350187 0.116580507148378 no 460 0.134097417864298 702 4418754 SGTC_1363 1636-0063 10.4 µM 1.10697549629357 0.116628541627467 no 461 0.134152261346851 730 6072185 SGTC_1922 5578187 25 µM 1.09920930463931 0.118105595669295 no 462 0.135838390566388 669 1350412 SGTC_2470 5664817 21.68 µM 1.09698750821343 0.118530583125365 no 463 0.136323426414829 707 2859561 SGTC_1049 3226-0134 66 µM 1.09024167959713 0.119827550359146 no 464 0.137803348926604 756 5702385 SGTC_1786 berberine 21.6 µM 1.09009635168461 0.119855601083313 no 465 0.137835351614001 693 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_978 1416-0512 87.4 µM 1.08933269491598 0.120003075724734 no 466 0.138003599942308 748 6814003 SGTC_2416 tofa 880 nM 1.0779518942189 0.12221606231301 no 467 0.140527612404856 649 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2744 captopril 92.04 µM 1.07699685157254 0.122403064082856 no 468 0.140740836127629 662 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1892 st058411 7.36 µM 1.07396065014169 0.122998900004121 no 469 0.141420159144579 794 3934738 SGTC_1727 st034309 9.9045 µM 1.0706491505136 0.123651076470902 no 470 0.14216360732097 809 870305 SGTC_2212 7123476 200 µM 1.06834265564285 0.124106752564723 no 471 0.14268298692727 641 1085715 SGTC_595 3909-8003 73.7 µM 1.0682333452029 0.12412837729241 no 472 0.142707633398812 725 699517 SGTC_444 curcumin 90.4 µM 1.06738493616726 0.124296306469496 no 473 0.142899023960033 758 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3309 9129340 25.759 µM 1.06652630524691 0.124466420621953 no 474 0.143092896995882 786 17158987 SGTC_2581 avocatin a 64 µM 1.06556959639744 0.124656157889681 no 475 0.143309124576698 749 6710728 A skin care supplement. SGTC_1991 st073000 8.92 µM 1.06449613951117 0.124869289533364 no 476 0.14355200115911 786 4301969 YIL048W NEO1 SGTC_2914 7968218 45.32 µM 1.05845076214063 0.126074335191144 no 477 0.144924993605689 713 2977111 SGTC_2367 9070478 135.38 µM 1.05811926196055 0.126140647929364 no 478 0.145000536923444 745 572802 SGTC_3068 9116768 49.47 µM 1.05730465228092 0.126303704349857 no 479 0.145186285357984 686 41904888 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.05665046471181 0.126434756164295 no 480 0.145335569995507 706 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1971 st069429 63.5 µM 1.05199264462267 0.127370584682069 no 481 0.146401462141239 730 1246522 YGL099W LSG1 SGTC_764 1951-2361 146 µM 1.05101204855317 0.127568214009431 no 482 0.146626528097803 726 5438930 SGTC_2088 5278280 127.392 µM 1.05039397252034 0.127692890537305 no 483 0.146768507861837 781 791502 SGTC_3302 9125395 16.351 µM 1.04995412036568 0.127781667824823 no 484 0.14686960353849 733 17599668 SGTC_900 1112-0045 141 µM 1.04943600939988 0.127886295443851 no 485 0.146988746132211 614 56211 YIL048W NEO1 SGTC_2855 9016525 58.44 µM 1.04807857247706 0.128160699260203 no 486 0.147301203842156 749 43811474 SGTC_2192 5915882 198.485 µM 1.04445221416323 0.128895766574907 no 487 0.148138108442917 709 2876149 SGTC_39 0986-0283 58.349 µM 1.04124558277212 0.129548186461808 no 488 0.148880792587438 842 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.04087759049449 0.129623204091779 no 489 0.148966181717234 809 676296 Flavone; oxidizing agent. SGTC_416 estradiol valerate 100 µM 1.04046773222089 0.129706791792198 no 490 0.149061323963336 751 13791 A steroid. SGTC_2634 4'-methoxyflavone 100 µM 1.03246347943037 0.13134668883682 no 491 0.15092752379618 709 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_364 0083-0097 67.7 µM 1.03185690524675 0.131471543649151 no 492 0.151069578350854 761 5207356 SGTC_1730 st033808 45.1 µM 1.03178284082945 0.13148679438453 no 493 0.15108692970514 838 1045166 SGTC_97 0535-0701 19.132 µM 1.03116028051257 0.131615035158097 no 494 0.151232831709864 723 2832013 YGL099W LSG1 SGTC_523 1934-0222 13.7 µM 1.02969374868436 0.131917466133444 no 495 0.151576895524498 762 1361595 SGTC_2587 piperic acid 92.2 µM 1.02961409445859 0.1319339062927 no 496 0.151595598132077 702 5370536 SGTC_1975 st070967 30.8 µM 1.02840281888319 0.132184080526735 no 497 0.151880191546695 844 261391 SGTC_1098 clofazimine 15.1 µM 1.02808861884127 0.132249028109473 no 498 0.15195407188224 811 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2348 9022543 33.42 µM 1.02705841973742 0.132462132538852 no 499 0.152196478163768 784 3162678 YDL140C RPO21 SGTC_272 doxorubicin 8.13 µM 1.02591741827123 0.132698433302873 no 500 0.152465255793009 806 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2376 9072922 81.32 µM 1.02457810571996 0.132976174409941 no 501 0.152781149795999 792 17087968 SGTC_3277 9138724 49.47 µM 1.02389014507909 0.133118996319198 no 502 0.152943582749731 692 15943418 SGTC_1689 st020265 53.493 µM 1.02190681817216 0.133531329435128 no 503 0.153412502568723 791 5758320 YPR016C TIF6 SGTC_797 k781-0471 270 µM 1.02069122682796 0.133784484250949 no 504 0.153700376188378 801 23738129 SGTC_2466 5983409 37.09 µM 1.01916042730482 0.134103752283012 no 505 0.1540634051323 756 2879657 SGTC_518 1021-0119 62.6 µM 1.0184521896238 0.13425164137299 no 506 0.154231555405937 735 1097762 SGTC_2013 4024628 200 µM 1.01712390509491 0.134529306124012 no 507 0.154547244792269 709 5230760 SGTC_897 1000-0139 31.4 µM 1.0155018498068 0.134868915052945 no 508 0.154933332613003 779 6151020 SGTC_2320 7373003 200 µM 1.01303647458902 0.135386214939055 no 509 0.155521369571461 759 5415828 SGTC_2975 9084847 53.72 µM 1.00913842508325 0.136206898946165 no 510 0.156454126038695 807 27211724 SGTC_1981 st071826 47 µM 1.00630509323934 0.136805552770407 no 511 0.157134415596725 742 11838600 SGTC_711 k292-0785 179 µM 1.00299721417969 0.137506746139524 no 512 0.157931102690171 797 4146315 SGTC_1866 st057638 64 µM 1.00248000702678 0.137616603426032 no 513 0.158055908946201 783 688802 SGTC_2318 6029776 164 µM 1.00210657384795 0.137695959660212 no 514 0.15814606162192 792 818325 SGTC_2595 hexamethylquercetagetin 100 µM 1.00173032317746 0.137775946201574 no 515 0.158236928610762 737 386331 SGTC_2706 st078239 82.5 µM 1.00072645950853 0.137989511123603 no 516 0.158479535847067 806 15434492 SGTC_1993 st073995 70.8 µM 0.999415519572954 0.138268744159997 no 517 0.158796722414556 813 3098394 SGTC_2580 diallyl disulphide 81.36 µM 0.997398312057877 0.138699165659529 no 518 0.159285605170179 756 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_166 k072-0058 166.424 µM 0.996616070859104 0.138866321640622 no 519 0.159475451115287 813 5846229 SGTC_343 4130-2827 29.8 µM 0.995842776337902 0.139031700602559 no 520 0.159663271277496 819 1118244 SGTC_645 0845-0943 5.41 µM 0.995336868637241 0.13913996798171 no 521 0.159786225998081 768 1885106 SGTC_77 0828-0286 12.516 µM 0.994661571236164 0.139284575202196 no 522 0.159950445331105 791 745345 SGTC_3347 9188721 44.724 µM 0.994658257138737 0.13928528513035 no 523 0.159951251527912 774 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_333 3486-0131 40.1 µM 0.994596730300099 0.139298465526484 no 524 0.159966219205093 847 6744690 SGTC_1904 st060225 78 µM 0.994317253722796 0.139358346211375 no 525 0.160034219197888 798 66595 SGTC_2720 fluspirilene 36.88 µM 0.994158333435541 0.139392404300433 no 526 0.160072894832694 728 3396 An atypical antipsychotic. SGTC_3168 9103419 49.47 µM 0.992774958916115 0.139689113442472 no 527 0.16040981788553 734 16649256 SGTC_1781 st038725 66.3 µM 0.99241865104126 0.139765604615082 no 528 0.160496672222886 861 4270275 YIL048W NEO1 SGTC_1109 tnp00067 928.257 nM 0.990162009597757 0.140250715248074 no 529 0.161047469103586 803 676295 SGTC_870 0573-2213 57.6 µM 0.988673363249076 0.14057135514903 no 530 0.161411489638608 780 3916321 SGTC_2195 6536160 144.242 µM 0.987767161860149 0.140766785546216 no 531 0.161633346717828 732 3834386 SGTC_412 gemfibrozil 100 µM 0.986163603227606 0.141113058808853 no 532 0.162026418290745 768 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1254 0550-0035 264 µM 0.985726990047732 0.141207441240687 no 533 0.162133550645863 863 15121435 SGTC_447 ml7 120 µM 0.985355760489311 0.141287723388617 no 534 0.162224676010567 830 4216 Selective myosin light chain kinase inhibitor. SGTC_2937 9044753 11.33 µM 0.9846286425768 0.141445059631542 no 535 0.162403257550365 855 6465530 YGL099W LSG1 SGTC_1502 4534-4282 27.7 µM 0.983833435581459 0.141617265106447 no 536 0.162598708323733 787 3278949 SGTC_1297 1068-0111 14.1 µM 0.977060803586829 0.143089662913828 no 537 0.16426952561088 794 767057 SGTC_1182 1222-0449 220 µM 0.977028834641663 0.143096637528293 no 538 0.164277438699261 801 658318 SGTC_2099 5377090 177.372 µM 0.973912292837047 0.143777671227727 no 539 0.165050044769381 799 2243829 SGTC_1631 benzylvanillin 81.9 µM 0.970903685703896 0.144437190181577 no 540 0.165798121311408 823 75506 SGTC_2965 9082772 38.63 µM 0.970894556469424 0.144439194505098 no 541 0.16580039458467 861 16459634 SGTC_234 nsc-17383 10.7 µM 0.966414474516482 0.145425058378923 no 542 0.166918412019558 891 408974 SGTC_2635 hydroquinidine 100 µM 0.965217868065424 0.145689141546204 no 543 0.167217849574019 834 442912 An experimental heart treatment. SGTC_344 k064-0035 6.43 µM 0.963193188344221 0.146136708868688 no 544 0.16772529141695 807 5088750 SGTC_1351 1496-0003 46.5 µM 0.961240798317293 0.146569169943823 no 545 0.1682155535629 875 3891978 SGTC_65 0798-0905 34.986 µM 0.95933432785985 0.14699228773721 no 546 0.168695173617034 924 3602145 SGTC_786 4544-0069 423 µM 0.959277333564259 0.147004949521238 no 547 0.168709525466461 861 748821 YLR208W SEC13 SGTC_2406 ethylparaben 405.7 µM 0.958621140898486 0.147150781179378 no 548 0.168874819199128 704 8434 A possible steroid mimic. SGTC_194 1486-1323 56.904 µM 0.957933136711214 0.14730378672122 no 549 0.169048237890492 827 5178754 SGTC_749 1000-0129 128 µM 0.956511839682325 0.147620207120206 no 550 0.169406852803881 895 708470 SGTC_1417 3966-0327 90.4 µM 0.955284661937317 0.147893777132751 no 551 0.169716880930413 891 651118 SGTC_930 2810-3379 265 µM 0.954923634369604 0.147974324191444 no 552 0.169808158385026 917 1015764 SGTC_3339 9145883 14.936 µM 0.954654508086544 0.148034386712831 no 553 0.169876221205177 806 2030670 SGTC_387 norethindrone acetate 66.7 µM 0.954213676128564 0.148132805064659 no 554 0.169987746676051 795 541197 SGTC_2517 totarol 10 µM 0.954163641470155 0.148143978365374 no 555 0.170000407840638 781 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_942 3253-1115 227 µM 0.953438305972051 0.148306017266135 no 556 0.170184020351884 855 46497897 SGTC_1397 3532-0190 20.1 µM 0.95167541351138 0.148700338980569 no 557 0.170630811096385 785 5322280 SGTC_1186 1319-0216 26 µM 0.948450286210218 0.149423543969336 no 558 0.171450134938182 905 4565136 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.942889745201399 0.15067594895738 no 559 0.17286865036206 877 688669 SGTC_1607 st000305 50.6 µM 0.942399961637119 0.150786597292022 no 560 0.172993953435946 868 5457690 SGTC_297 0986-0032 24 µM 0.942234827371929 0.150823915413393 no 561 0.173036213363678 836 2847425 SGTC_2460 5552655 174.22 µM 0.939361021823323 0.151474341330607 no 562 0.173772709113672 834 5401989 SGTC_2748 diazoxide 86.69 µM 0.93892794198932 0.151572521376425 no 563 0.17388387097753 807 3019 A potassium channel activatior. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.938413649445625 0.151689167437296 no 564 0.174015937042401 920 66535 A nucleotide analog. SGTC_3041 9091929 49.47 µM 0.937983422827504 0.151786792426736 no 565 0.174126464647318 895 25236887 SGTC_654 1124-0271 80.9 µM 0.937724640680334 0.151845534152336 no 566 0.174192968704174 874 5403748 SGTC_2556 citropten 84.59 µM 0.937697367400386 0.151851725874575 no 567 0.174199978565858 941 2775 A potential DNA crosslinker. SGTC_433 pimozide 108 µM 0.937161205845181 0.15197348213033 no 568 0.174337820849064 746 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2100 5377183 190 µM 0.935287972544958 0.152399381275545 no 569 0.174819955995897 942 2844202 SGTC_3138 9097216 49.47 µM 0.934530176675097 0.152571898915326 no 570 0.175015238651177 950 25237486 SGTC_2900 5328528 85.29 µM 0.930481144428158 0.153495885085135 no 571 0.176061011181127 941 795359 SGTC_2215 7188065 200 µM 0.929004154744363 0.15383385363774 no 572 0.176443466584959 848 940217 SGTC_375 3970-0961 9.27 µM 0.928571004830363 0.153933061437038 no 573 0.17655572709707 879 2898222 SGTC_640 3381-0960 37.1 µM 0.92071236349582 0.155740340344496 no 574 0.178600309786506 941 1745025 SGTC_708 3448-5400 146 µM 0.920587503983733 0.155769167183013 no 575 0.178632914358325 882 3462195 SGTC_89 0302-0250 142.109 µM 0.920374369938286 0.155818382460993 no 576 0.178688578723458 948 4203518 YLR208W SEC13 SGTC_1125 tnp00248 1.32998 µM 0.919988603870306 0.1559074866691 no 577 0.178789357282557 1008 24207736 SGTC_2731 amoxapine 43.43 µM 0.919009291010471 0.156133839097735 no 578 0.179045356264005 846 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.916780083471072 0.156649891656649 no 579 0.179628945599926 855 6708514 SGTC_2346 9031566 143.75 µM 0.914445784544154 0.157191474494081 no 580 0.180241326691411 892 4771086 SGTC_3002 9075603 71.4286 µM 0.91275443945061 0.157584653349607 no 581 0.18068585256851 935 20105405 SGTC_2774 tamoxifen 10.92 µM 0.908991077477131 0.158461820522994 no 582 0.181677417817341 891 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2628 lathosterol 100 µM 0.908723766367325 0.158524247180264 no 583 0.181747977840853 905 6710616 SGTC_254 nsc-64875 3.808 µM 0.90673405663894 0.158989421994144 no 584 0.18227372456898 937 56993 SGTC_341 1486-1430 230 µM 0.905764582022788 0.159216399491132 no 585 0.182530235643022 882 2054753 YPL210C SRP72 SGTC_2760 etidronate 98.04 µM 0.904727826517246 0.159459363794789 no 586 0.182804797758992 865 3305 A chelator and antioxidant. SGTC_233 rapamycin 362 pM 0.900505631886185 0.160451343431732 no 587 0.183925614773796 979 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1272 0839-0021 27 µM 0.898182464996181 0.160998873630898 no 588 0.184544140099338 911 5027250 SGTC_2026 5148700 152 µM 0.897716255256114 0.161108897932055 no 589 0.184668420530924 918 79838 SGTC_1560 lithocholic acid 53.1 µM 0.889288111065152 0.163106376374695 no 590 0.186924129672352 872 9903 A bile acid which acts as a detergent. SGTC_2800 7887935 81.82 µM 0.889076832584257 0.163156655516096 no 591 0.186980894438006 869 2961002 SGTC_562 3772-2733 112 µM 0.885205732493381 0.16407966590274 no 592 0.188022840558354 992 2876874 YIL048W NEO1 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.882362105471698 0.164759843229091 no 593 0.18879051061105 902 5355888 SGTC_1160 4092-0570 10.5 µM 0.881060541344564 0.165071777489458 no 594 0.189142526395614 922 4994975 SGTC_1804 st050076 49.1 µM 0.880292137684901 0.165256113309226 no 595 0.189350535374683 927 3895976 SGTC_277 nystatin 15.5 µM 0.879824850773419 0.165368277988058 no 596 0.189477100047946 993 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1277 0873-0036 22 µM 0.878631648986471 0.165654910227705 no 597 0.189800514891941 969 5965735 SGTC_1651 st011928 86.1 µM 0.878270629994794 0.165741697873825 no 598 0.189898435186683 915 720198 SGTC_3200 9114385 49.47 µM 0.87764640077245 0.165891829642864 no 599 0.190067820068053 885 17018030 YLR208W SEC13 SGTC_1946 st076057 65.1 µM 0.876257247589195 0.16622624665586 no 600 0.190445100520677 829 953009 SGTC_1019 4262-0212 3.4 µM 0.875367794912 0.166440597042045 no 601 0.190686908509605 1042 4677213 SGTC_3204 9114183 49.47 µM 0.875143745283753 0.166494619185866 no 602 0.190747848688963 878 17027248 SGTC_3081 9117243 49.47 µM 0.873713607978452 0.166839716094886 no 603 0.191137119170709 950 45595589 SGTC_2127 5253358 187.912 µM 0.872372691336755 0.167163702608562 no 604 0.191502546706282 850 20612 SGTC_2883 9059145 45.46 µM 0.870919708053709 0.167515223735097 no 605 0.191898997548976 913 16476510 SGTC_1009 4106-0057 9.87 µM 0.868446666501142 0.168114622387766 no 606 0.192574928583878 1004 2928005 SGTC_1356 1502-0781 85.8 µM 0.868367183091418 0.168133909887482 no 607 0.19259667707737 912 567702 SGTC_2400 5203494 178.7 µM 0.867712924377492 0.168292726855903 no 608 0.192775754377196 882 6777674 SGTC_779 1360-0071 233 µM 0.867234255573619 0.168408981640059 no 609 0.192906835340873 1008 7566 SGTC_2146 5545642 200 µM 0.867098714144609 0.168441910106136 no 610 0.19294396254453 988 825326 SGTC_2950 9072895 21.46 µM 0.865790139870001 0.168760028350049 no 611 0.193302628676045 982 17332245 SGTC_3096 9117468 49.47 µM 0.865668461321883 0.168789628368407 no 612 0.193336000120291 854 41316311 SGTC_2801 7907800 81.82 µM 0.864549915274124 0.169061886705547 no 613 0.193642936179324 950 6620925 SGTC_3296 9122258 64.045 µM 0.862662813329088 0.169521853362004 no 614 0.194161441879752 946 4730474 SGTC_2553 4-methylesculetin 85.09 µM 0.862574432331991 0.169543415218876 no 615 0.19418574641586 997 5319502 SGTC_2103 5378138 10 µM 0.861869795095159 0.169715384871599 no 616 0.194379586030311 1031 244142 SGTC_1750 st081859 2.357 µM 0.861782234206709 0.169736762283223 no 617 0.194403681500077 1054 5291695 SGTC_1851 st056236 18.9 µM 0.85979555786893 0.170222260225313 no 618 0.194950874187073 1002 5393171 SGTC_2199 6590217 200 µM 0.85756949547763 0.170767314526587 no 619 0.195565112590286 911 703109 SGTC_2537 larixol 68.93 µM 0.85735058233875 0.17082097595441 no 620 0.195625580791805 997 6708759 SGTC_3025 9087895 49.47 µM 0.855801057591102 0.171201114109845 no 621 0.19605391507274 1020 17173641 SGTC_2268 7933382 153.85 µM 0.855767902450814 0.171209253822484 no 622 0.196063086342033 1070 935025 YOR257W CDC31 SGTC_1512 0259-0544 12.2 µM 0.85308848737144 0.171867878369871 no 623 0.196805117631694 990 18476 SGTC_1755 st041960 45.185 µM 0.85208034342329 0.172116107645045 no 624 0.197084750513559 967 2257073 SGTC_2198 6589944 200 µM 0.850366975649922 0.172538504602457 no 625 0.1975605453496 895 5290268 SGTC_927 2425-1185 123 µM 0.848939731941561 0.172890867562739 no 626 0.197957414416104 952 730375 SGTC_3354 9151612 71.43 µM 0.841761586481416 0.174669979382428 no 627 0.199960708850989 1005 27261949 SGTC_2645 abamectin 100 µM 0.841255466287251 0.17479585903534 no 628 0.200102416672471 958 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1269 0831-0796 3.05 µM 0.841089870090001 0.174837057782595 no 629 0.200148794802653 995 927758 SGTC_3175 9106517 49.47 µM 0.840463082992449 0.174993052212805 no 630 0.200324396060776 963 41468073 SGTC_835 0312-0010 67.2 µM 0.840402813484313 0.175008056707665 no 631 0.200341286099152 942 1626196 SGTC_2511 berberine 10.47 µM 0.840133563329778 0.175075098292658 no 632 0.200416751708086 953 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2066 5222451 176 µM 0.839219653329575 0.175302777582834 no 633 0.200673030312652 1052 2281147 SGTC_2238 6671620 73.2395 µM 0.837216497000671 0.175802473501776 no 634 0.201235443071297 1023 729941 SGTC_1052 3253-3998 198 µM 0.836434714163245 0.175997737107246 no 635 0.201455195131682 1037 5450317 SGTC_553 k007-0256 45.7 µM 0.836361380452093 0.176016060495245 no 636 0.201475815947242 1008 6287000 SGTC_59 0330-0160 1.33 µM 0.835474503815767 0.176237753860687 no 637 0.20172529824128 1064 4293482 SGTC_627 1391-0720 175 µM 0.833466364516247 0.176740382997939 no 638 0.202290879972196 956 997839 SGTC_2994 9053520 71.4286 µM 0.832828988438137 0.176900104933601 no 639 0.202470591655462 995 4647384 SGTC_1163 k060-0048 49.9 µM 0.832787189604628 0.176910582611919 no 640 0.202482380400227 1042 6809982 SGTC_1604 st002052 72.4 µM 0.831904003148009 0.177132061901967 no 641 0.202731566050447 983 6254834 YHR062C RPP1 SGTC_2570 licareol 100 µM 0.825881440782974 0.178647023899039 no 642 0.204435674775889 935 443158 SGTC_2694 st077685 81.9 µM 0.824926055218366 0.178888096634849 no 643 0.204706786437815 988 2838096 SGTC_3280 9140961 49.47 µM 0.824442208516122 0.179010263888767 no 644 0.204844170122652 951 4901226 SGTC_231 b-estradiol 524 µM 0.818266941099695 0.180574075349137 no 645 0.206602389305537 950 450 A steroid. SGTC_2459 5811157 9.22 µM 0.817642108360643 0.180732782575494 no 646 0.206780787956019 1039 2870684 YBR192W RIM2 SGTC_2317 5986382 200 µM 0.814946850782264 0.181418378526523 no 647 0.207551366880465 1042 877883 SGTC_472 calcifediol 10 µM 0.81037938498813 0.182583922181148 no 648 0.208861081178478 958 5283731 A vitamin D metabolite. SGTC_2806 7952793 58.44 µM 0.809929818932694 0.182698896450561 no 649 0.208990256300735 1006 2972490 SGTC_124 0136-0217 7.121 µM 0.806757831857196 0.183511400388864 no 650 0.209903008983424 1176 3976905 SGTC_1281 0884-0031 11.8 µM 0.806477278597191 0.183583372305845 no 651 0.209983851991948 1033 1548255 SGTC_1206 3978-0017 132 µM 0.805406049293892 0.183858342607308 no 652 0.210292701032859 985 3873677 SGTC_2134 5324836 1.464 µM 0.803280634292297 0.184404667223063 no 653 0.21090627428153 970 699272 SGTC_2252 omeprazole 400 µM 0.802948395461528 0.184490158314273 no 654 0.211002281087382 961 4594 A proton pump inhibitor. SGTC_448 monastrol 171 µM 0.801509565137178 0.184860679999165 no 655 0.211418354432613 1059 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3166 9102297 49.47 µM 0.800457989643502 0.185131769714877 no 656 0.211722747159735 1027 25237072 SGTC_818 4072-2707 53.5 µM 0.799104405676752 0.185481078642063 no 657 0.212114937624427 1040 882871 SGTC_783 0848-0141 92.7 µM 0.799101640788837 0.18548179257366 no 658 0.212115739163742 972 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2235 salicylic acid 500 µM 0.798381294567336 0.185667853853266 no 659 0.212324627420537 1057 338 A COX inhibitor and kinase inhibitor. SGTC_1863 st057641 20.1 µM 0.797645536596709 0.185858015394874 no 660 0.212538108876861 1092 3921635 SGTC_2783 7738165 71.43 µM 0.796984733076139 0.186028907378336 no 661 0.21272994899325 959 17201110 SGTC_1284 0929-0043 16 µM 0.794879423321136 0.186574015866296 no 662 0.213341822363575 1036 1239883 SGTC_3191 9110352 49.47 µM 0.792557633597559 0.187176321101613 no 663 0.214017800296773 1029 17122424 SGTC_2555 cholic acid 100 µM 0.789080233560658 0.188080654250573 no 664 0.215032557001436 1030 6708657 Influences liver metabolism. SGTC_1623 st003709 20.3 µM 0.787611768185371 0.188463352073764 no 665 0.215461914497607 1046 16192618 SGTC_2450 5739737 12.93 µM 0.785532661773699 0.189006010124558 no 666 0.216070664053004 1020 2262825 SGTC_582 0987-0078 156 µM 0.783834952725298 0.189449834481584 no 667 0.216568480826477 1161 1625765 SGTC_2189 6047310 154.431 µM 0.782802503570572 0.189720056326264 no 668 0.216871548587275 1044 711535 SGTC_3137 9097352 49.47 µM 0.781361038267107 0.190097725840003 no 669 0.217295089845776 1139 44120435 SGTC_1129 3453-1384 223 µM 0.779967207252796 0.190463354020614 no 670 0.217705088779604 1072 1084452 SGTC_789 1309-1135 70.6 µM 0.779378525840095 0.190617905882172 no 671 0.217878384883356 1105 3092424 SGTC_1228 0124-0032 52.5 µM 0.778412837393845 0.190871603480044 no 672 0.218162836584849 1096 X1228 SGTC_2427 5545055 42.75 µM 0.777952714616364 0.1909925559217 no 673 0.218298444888273 1109 5372858 SGTC_3093 9117344 49.47 µM 0.777264942406642 0.191173438182374 no 674 0.21850123700656 1017 24824913 SGTC_946 3434-1334 87.4 µM 0.776377228238239 0.191407059853284 no 675 0.218763143033396 1043 4047976 SGTC_962 1254-0300 21.5 µM 0.773913078174172 0.192056471861994 no 676 0.219491097563039 1047 7340576 SGTC_610 4215-0184 155 µM 0.773191817987306 0.192246810452489 no 677 0.219704433844033 1076 5605015 SGTC_2722 naftopidil 47.16 µM 0.772590367783346 0.192405619708352 no 678 0.219882423402015 1095 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_961 1252-1571 372 µM 0.77148710525786 0.192697137894467 no 679 0.220209131315995 1043 6813498 SGTC_2972 9093619 59.92 µM 0.770167080095203 0.19304628632273 no 680 0.220600394450514 1050 25236256 SGTC_3101 9120531 49.47 µM 0.768665925500467 0.193443812812058 no 681 0.221045829022512 1082 24824904 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.767300754510545 0.193805762211467 no 682 0.221451359972766 1109 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3225 9130819 49.47 µM 0.766919319973734 0.193906966142079 no 683 0.22156474301055 1079 4547121 SGTC_450 aminopyrene 156 nM 0.765448277111229 0.194297571400386 no 684 0.222002327358053 1073 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2175 5807670 165.306 µM 0.76029268566135 0.195670310757751 no 685 0.223539826499475 1077 241186 SGTC_2294 7971431 200 µM 0.759744766630695 0.195816546229502 no 686 0.223703582046879 1015 5741572 SGTC_587 k089-0003 57 µM 0.758662445450505 0.19610560445946 no 687 0.224027253718605 1043 9659696 SGTC_3094 9117742 49.47 µM 0.758542159401293 0.196137745527143 no 688 0.224063242072728 1115 17149698 SGTC_2361 9034121 116 µM 0.75776967861395 0.196344232599887 no 689 0.224294438664488 1084 6496917 SGTC_1674 st016616 23.6 µM 0.757099079937104 0.196523592999627 no 690 0.224495252623079 1119 625830 SGTC_335 4077-0256 27.6 µM 0.754818722863241 0.19713424677187 no 691 0.225178879156456 1154 3121989 SGTC_99 0109-0120 622.8 µM 0.754346736343698 0.197260782680671 no 692 0.225320522798426 1096 759414 SGTC_2626 ethyl orsellinate 100 µM 0.753539253884988 0.197477376337346 no 693 0.2255629660738 1111 75653 A natural product. SGTC_1675 st018485 24.5 µM 0.752952644063592 0.197634814745447 no 694 0.225739185794607 1094 3323024 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.749387665466977 0.198593238904961 no 695 0.226811791562927 1118 5357218 A potent inhibitor of glutathione S-transferases. SGTC_782 0083-0095 30.5 µM 0.742402725714008 0.200479208649158 no 696 0.228921684300644 1158 3591729 An indicator and reagent. SGTC_175 3793-3120 23.7 µM 0.741999333938632 0.200588454061745 no 697 0.229043869572732 1124 5322297 SGTC_636 0kpi-0074 126 µM 0.741458726665022 0.200734915822352 no 698 0.229207674061102 1093 616434 SGTC_3049 9092223 49.47 µM 0.740428529385762 0.201014195355508 no 699 0.229520006557218 1067 8623917 SGTC_2832 7992762 51.95 µM 0.740210586822202 0.201073307971139 no 700 0.229586112357956 1025 2985177 SGTC_1525 8-methoxypsoralen 92.5 µM 0.739981761874588 0.201135383437379 no 701 0.229655530453935 1174 4114 Related to psoralen; DNA damaging agent. SGTC_1340 1486-1359 257 µM 0.739005425480934 0.201400372371471 no 702 0.22995185143252 1116 4309068 SGTC_1200 1643-0193 18.4 µM 0.738872974371833 0.201436337238191 no 703 0.229992067213701 1157 5403974 SGTC_363 0455-0021 3.06 µM 0.738840222853706 0.201445230954533 no 704 0.230002012077792 1130 4597466 SGTC_310 1273-0058 1.06 µM 0.738444064416259 0.201552826918365 no 705 0.230122323020593 1169 2734232 SGTC_2239 6685329 187.64 µM 0.73776966703525 0.201736071289451 no 706 0.230327214425946 1095 805680 SGTC_969 1313-0238 134 µM 0.73599097955313 0.202219847001445 no 707 0.230868093701189 1159 5212874 SGTC_684 1140-0066 328 µM 0.735287638015071 0.202411336428706 no 708 0.231082167640093 1157 6813534 SGTC_614 0462-0418 107 µM 0.7341640310712 0.202717470790296 no 709 0.231424386232457 1028 5188303 SGTC_1037 k284-1091 78.7 µM 0.732188363762105 0.203256425261395 no 710 0.232026802825889 1126 3334711 SGTC_2966 9084041 48.03 µM 0.729698672075219 0.203936820109074 no 711 0.232787196502405 1099 17741380 SGTC_318 1488-0629 67.2 µM 0.728573334767426 0.204244802513645 no 712 0.23313134728581 1131 3662576 SGTC_1090 efavirenz 20.7 µM 0.725974856380196 0.204957011565324 no 713 0.233927092336314 1149 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_142 0335-0849 62.6745 µM 0.725081948610503 0.205202086382283 no 714 0.234200878948073 1168 3889043 YPR107C YTH1 SGTC_2057 5236571 38.335 µM 0.723927870412855 0.20551910201269 no 715 0.234555009262593 1150 54684039 YBR257W POP4 SGTC_1557 sumaresinolic acid 42.3 µM 0.721170571813775 0.206277685209081 no 716 0.235402287669161 1113 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3023 9089636 49.47 µM 0.720636733670199 0.2064247453551 no 717 0.235566523455015 1247 17249241 SGTC_144 4161-2749 112.381 µM 0.718188709607001 0.207099914902314 no 718 0.236320469259152 1063 797501 YMR168C CEP3 SGTC_1671 st016596 74.5 µM 0.714339569213392 0.20816415286052 no 719 0.237508614959081 1213 2829167 SGTC_198 3454-2873 16.191 µM 0.713015956655373 0.208530859148986 no 720 0.237917941620361 1167 710957 SGTC_3209 9113616 49.47 µM 0.712280875928864 0.20873467734658 no 721 0.238145431988185 1189 16649353 SGTC_130 0136-0219 337.655 µM 0.707280884172814 0.21012415331348 no 722 0.23969597122432 1145 234244 SGTC_1448 4255-0083 152 µM 0.707206251298162 0.210144934536376 no 723 0.239719157158831 1215 5399660 SGTC_1436 4092-1007 8.32 µM 0.702063133057112 0.211579921065459 no 724 0.24131989623367 1166 2881121 SGTC_1252 0493-0875 34.8 µM 0.701922745549804 0.211619170984579 no 725 0.241363671586198 1201 3960963 SGTC_3276 9139060 49.47 µM 0.701019208763157 0.211871886216931 no 726 0.241645513833741 1248 4870619 SGTC_1845 st056753 3.01 µM 0.700992568225474 0.211879340135803 no 727 0.241653826586958 1154 5375839 SGTC_3001 9076041 71.4286 µM 0.700898560579554 0.211905644335463 no 728 0.241683161408034 1206 16004211 SGTC_3173 9105693 49.47 µM 0.698371386949731 0.21261348629973 no 729 0.242472482814821 1241 17096658 SGTC_2895 9054447 58.44 µM 0.697662300121798 0.212812343886362 no 730 0.242694205111621 1216 2697450 SGTC_3125 9127534 49.47 µM 0.695083821969101 0.213536371530236 no 731 0.243501386365085 1086 1639235 SGTC_1803 st050068 52.4 µM 0.692809084967412 0.214176299836593 no 732 0.244214685043088 1287 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.692715013686645 0.214202787944562 no 733 0.244244207600791 1160 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2485 5633444 17.78 µM 0.692280443674266 0.214325176672887 no 734 0.24438061445235 1181 5724239 SGTC_2484 5809818 12.04 µM 0.692093984474296 0.214377701977458 no 735 0.244439154573139 1195 2870548 SGTC_1765 st044815 90.4 µM 0.690496517543016 0.214828012968612 no 736 0.244940999587148 1187 645695 SGTC_987 1497-1013 404 µM 0.690235989570014 0.214901505450604 no 737 0.245022897124437 1189 1676435 SGTC_138 0850-0259 40.9225 µM 0.689148351473129 0.215208475588378 no 738 0.245364957595175 1239 6813004 SGTC_127 0180-0333 59.125 µM 0.686721579258702 0.215894313675762 no 739 0.246129097906435 1196 771601 SGTC_189 3970-0742 2.116 µM 0.686609912048651 0.215925902763985 no 740 0.246164290288926 1219 2891807 SGTC_285 1486-1325 46 µM 0.685828755223103 0.216146955960605 no 741 0.246410550537326 1209 22310230 SGTC_2343 7990716 14.84 µM 0.685603078008032 0.216210842906134 no 742 0.246481720014347 1194 6456862 SGTC_286 k060-0067 22.9 µM 0.685158227372587 0.21633680765164 no 743 0.246622040181243 1189 5985051 SGTC_1763 st044482 94.5 µM 0.684441115798248 0.216539955727536 no 744 0.246848330235331 1202 88505 SGTC_1278 0874-0585 172 µM 0.684024636687764 0.216657989310763 no 745 0.246979804411571 1217 766306 SGTC_1251 0490-5699 265 µM 0.683959363852396 0.216676491538318 no 746 0.24700041314401 1258 3883818 SGTC_3286 9117135 37.221 µM 0.68315331610438 0.216905049016705 no 747 0.247254984149969 1183 3438150 SGTC_1940 st075990 51.1 µM 0.68232169815971 0.217141003008742 no 748 0.247517777855253 1313 1084979 SGTC_1724 st037281 8.293 µM 0.680898102005886 0.217545262296864 no 749 0.247967984570969 1231 574124 YDL195W SEC31 SGTC_245 methotrexate 289.6 µM 0.680860936011295 0.21755582215744 no 750 0.247979744021601 1221 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2305 7443522 69.23 µM 0.680794101090256 0.217574812503841 no 751 0.248000891572999 1198 5415886 SGTC_1053 3366-3204 134 µM 0.67866361936866 0.218180664616341 no 752 0.248675511254214 1197 3632071 YPR165W RHO1 SGTC_1317 1273-0028 910 nM 0.677926269758436 0.218390573407213 no 753 0.248909221384438 1203 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_316 k060-0003 58.6 µM 0.677924756982452 0.218391004184029 no 754 0.248909700993639 1239 6152314 SGTC_655 k060-0012 42 µM 0.676816221770045 0.218706801296945 no 755 0.24926128224602 1189 5994525 SGTC_1189 1431-2119 7.28 µM 0.676439301691616 0.218814237318896 no 756 0.24938088574192 1251 3107275 SGTC_408 cantharidin 100 µM 0.676180120542773 0.218888131052144 no 757 0.249463146262085 1197 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1058 3448-5425 97.3 µM 0.674869869181917 0.219261909381783 no 758 0.249879222577881 1169 7279705 SGTC_3331 9141060 1.957 µM 0.674610965652209 0.219335810753572 no 759 0.249961482142494 1221 4906567 YPR165W RHO1 SGTC_723 4182-0001 115 µM 0.674196338346657 0.219454191701375 no 760 0.250093248637359 1193 744821 YLR208W SEC13 SGTC_563 tetrahydrosecaminediol 614 µM 0.672783475567866 0.219857856100282 no 761 0.250542525967363 1270 334274 A psychoactive constituent of the cannabis plant. SGTC_2836 9010338 19.48 µM 0.672372262852281 0.219975422355426 no 762 0.250673368113414 1149 2994051 SGTC_1505 k297-0037 20.6 µM 0.671159990864836 0.220322222351922 no 763 0.251059306648839 1228 4089396 SGTC_2944 9067346 25.62 µM 0.668418844318332 0.221107548842612 no 764 0.251933134964944 1193 6473075 SGTC_1746 st038117 42 µM 0.667725152567964 0.221306542156404 no 765 0.252154525674302 1244 2898218 SGTC_1648 st011736 69.8 µM 0.667473346814709 0.221378800810882 no 766 0.252234914489825 1262 2855514 SGTC_2202 7226349 200 µM 0.664427095021752 0.222254027133149 no 767 0.253208497992404 1201 844334 SGTC_735 3076-0345 636 µM 0.66359671420326 0.222492947954057 no 768 0.253474230438017 1276 2888990 SGTC_2201 6605497 169.863 µM 0.66241721818379 0.222832569376523 no 769 0.253851935956278 1242 670741 SGTC_1809 st050081 57.6 µM 0.661268760725124 0.223163537262503 no 770 0.254219985789451 1313 5036894 SGTC_2771 fluoxetine 41.05 µM 0.661268705068368 0.223163553308708 no 771 0.254220003632728 1258 3386 A selective serotonin reuptake inhibitor. SGTC_2153 5569715 200 µM 0.656768822953768 0.224463043805111 no 772 0.255664786901829 1269 2054701 SGTC_2370 9071495 200 µM 0.654125420398742 0.225228411972473 no 773 0.256515502647564 1209 21791103 SGTC_1439 4092-1168 46 µM 0.652003997082198 0.22584371446508 no 774 0.257199296933254 1264 2886240 SGTC_201 4262-0159 12.803 µM 0.651079149336577 0.226112256699209 no 775 0.257497697676803 1226 1341029 SGTC_543 3844-1095 191 µM 0.651034345202756 0.226125270775665 no 776 0.257512158229386 1271 4230703 SGTC_1375 2910-0797 186 µM 0.650580338806137 0.226257168061805 no 777 0.257658712770147 1263 742508 SGTC_1135 dihydrocapsaicin 536.708 nM 0.650348852411696 0.226324435883506 no 778 0.257733453894758 1229 107982 A Capsaicinoid. SGTC_2711 st079103 59.1 µM 0.649785172081235 0.226488283450713 no 779 0.257915499129693 1261 54693780 SGTC_2868 9035608 32.47 µM 0.649499042579585 0.226571479655793 no 780 0.258007932544217 1257 6462614 SGTC_989 1501-0895 10.3 µM 0.649022466293884 0.226710089250187 no 781 0.258161927447128 1265 2830112 SGTC_2856 9022925 19.48 µM 0.648785738171242 0.22677895810826 no 782 0.258238438523482 1272 4944862 SGTC_2708 st078559 56 µM 0.646709178910889 0.227383575617377 no 783 0.258910090677613 1208 17250902 SGTC_1729 st035615 45.989 µM 0.646322087541834 0.227496382689618 no 784 0.259035393199948 1261 17385451 SGTC_273 hydroxyurea 18.1 mM 0.645323828101898 0.227787443194742 no 785 0.259358677136805 1308 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1511 0906-3109 28.5 µM 0.644758370451306 0.227952405482145 no 786 0.259541891683686 1309 2882180 SGTC_1383 3049-0032 20.7 µM 0.642933205499414 0.228485323429203 no 787 0.260133721033403 1299 712864 SGTC_2299 7976368 114.88 µM 0.642630797616604 0.228573689067326 no 788 0.260231847176483 1281 2979718 SGTC_1649 st011737 51.3 µM 0.641924233828081 0.228780226606406 no 789 0.260461189267726 1268 1761035 SGTC_2912 7964298 10.93 µM 0.641446522833329 0.228919926918622 no 790 0.26061630745656 1297 2975850 SGTC_834 0312-0008 75.7 µM 0.637174723137194 0.230171284567716 no 791 0.262005520170505 1300 6385573 YIL048W NEO1 SGTC_1459 k035-0031 35.7 µM 0.636286960197273 0.230431820400435 no 792 0.262294701263928 1182 3877128 YMR208W ERG12 SGTC_608 k048-0125 159 µM 0.630249821808657 0.232207932797729 no 793 0.264265573595453 1329 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_466 geldanamycin 89.2 µM 0.629705319097929 0.232368497945986 no 794 0.264443700903866 1210 5288382 HSP90 inhibitor. SGTC_1529 apigenin 74 µM 0.629465179717315 0.232439330832262 no 795 0.264522278936672 1389 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_496 calpeptin 138 µM 0.626801676436992 0.233225777754724 no 796 0.265394622240983 1257 73364 A calpain inhibitor. SGTC_3319 9138450 16.7555 µM 0.625848793898546 0.233507491633724 no 797 0.2657070619237 1285 2029690 SGTC_1513 0337-0559 19 µM 0.625000985133795 0.233758299677425 no 798 0.26598520576634 1241 775073 SGTC_620 0109-0052 432 µM 0.623661173620007 0.234154961606086 no 799 0.266425063347139 1307 493037 SGTC_2528 xanthyletin 44.79 µM 0.623522494630219 0.234196039905574 no 800 0.266470612403859 1345 65188 An natural product with antifungal activity of unknown mechanism. SGTC_958 1222-0007 33 µM 0.623013696507995 0.234346785883196 no 801 0.266637760667059 1391 7312461 SGTC_3040 9091894 49.47 µM 0.622048501886135 0.234632899863478 no 802 0.266954988020463 1247 25236966 SGTC_3100 9120536 49.47 µM 0.619858093559392 0.235282921718497 no 803 0.26767560884803 1216 16421196 SGTC_3171 9103192 49.47 µM 0.618825282430341 0.235589761563848 no 804 0.268015732417514 1351 13018434 SGTC_3212 9128307 49.47 µM 0.616539363803611 0.236269673831345 no 805 0.268769300111447 1263 27243542 SGTC_677 0929-0063 136 µM 0.615959909776448 0.236442195264376 no 806 0.268960489782683 1297 1539583 SGTC_1322 1348-1070 12 µM 0.615629715249179 0.236540535419487 no 807 0.269069467321574 1288 6758089 SGTC_76 0433-0009 400.328 µM 0.615203992891152 0.236667359351484 no 808 0.269210005600852 1326 2841569 SGTC_1752 st044819 83.042 µM 0.614637482327624 0.236836182490934 no 809 0.269397077574571 1261 441209 YML126C ERG13 SGTC_519 k048-0011 62.8 µM 0.61440872778285 0.236904371316173 no 810 0.269472634905182 1334 6836379 SGTC_1908 st060353 56.5 µM 0.614147808626962 0.236982161178002 no 811 0.269558829130299 1379 4227716 SGTC_3032 9089427 49.47 µM 0.613704549577812 0.23711434563239 no 812 0.269705290710841 1289 17173707 SGTC_905 2-aminofluorene 215 µM 0.612892120035443 0.237356725700349 no 813 0.269973836978803 1338 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2576 guaiol 23.12 µM 0.611785866220945 0.23768698387729 no 814 0.270339721057411 1315 227829 SGTC_936 3005-4620 401 µM 0.610847292293146 0.237967380896353 no 815 0.270650340681204 1404 777207 SGTC_13 0199-0087 65 µM 0.610616925841942 0.23803623010334 no 816 0.270726607343841 1341 4589825 SGTC_1963 st076565 50.3 µM 0.608863781677299 0.238560546697171 no 817 0.271307366337142 1342 4914280 SGTC_2733 amorolfine 100 µM 0.608010600090585 0.238815938044976 no 818 0.271590221774477 1370 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1885 st057546 99.9 µM 0.607955586921712 0.238832410816053 no 819 0.27160846533804 1391 702008 SGTC_3231 9132313 49.47 µM 0.60770687878916 0.238906890051927 no 820 0.271690949979499 1342 4905967 SGTC_750 4073-0104 132 µM 0.607391042037697 0.239001490224204 no 821 0.271795715955776 1206 22330957 SGTC_1608 st001473 40.5 µM 0.607342326845951 0.239016083336692 no 822 0.271811877025537 1287 7292267 SGTC_2662 daunorubicin 22.37 µM 0.60713837259235 0.239077185118245 no 823 0.271879543223668 1288 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_896 0964-0007 44.5 µM 0.605814166223487 0.239474106036572 no 824 0.272319080830161 1317 6756758 SGTC_2769 toremifene 3.73 µM 0.605204285128287 0.239657034270033 no 825 0.272521634473745 1357 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_338 4055-0136 114 µM 0.60477817096277 0.239784888543309 no 826 0.272663199841527 1290 2900563 SGTC_2228 7354201 200 µM 0.604006844346389 0.240016417392807 no 827 0.272919545871206 1350 753451 SGTC_2452 5863136 48.41 µM 0.60376342614007 0.240089509449529 no 828 0.27300046933485 1306 2184096 SGTC_2987 9018338 71.43 µM 0.603333141278063 0.24021874230361 no 829 0.273143545005493 1366 5055682 SGTC_283 0987-0079 11.7 µM 0.603125804366229 0.240281027932786 no 830 0.273212500661456 1349 411556 SGTC_1016 4226-1401 38 µM 0.602975556539714 0.240326169052644 no 831 0.273262475143304 1330 2901613 SGTC_2655 perillic acid 100 µM 0.602520669254428 0.240462865560458 no 832 0.273413804477215 1310 5702197 An apoptosis inducer. SGTC_1141 3253-0389 52.6 µM 0.602302963326855 0.240528302548738 no 833 0.273486244334535 1310 5402031 SGTC_90 0870-0863 4.608 µM 0.601969542186162 0.240628539446502 no 834 0.273597205891547 1317 1738164 SGTC_2693 st077581 40.7 µM 0.600863105080053 0.240961332167455 no 835 0.273965584396099 1346 25238761 SGTC_799 1310-0557 151 µM 0.600383483700714 0.24110566980263 no 836 0.27412534624937 1363 5354492 SGTC_643 k048-0106 28.4 µM 0.595358441089134 0.242620732456354 no 837 0.27580194951458 1378 6763920 SGTC_1132 3456-3614 2.5 µM 0.593140041777102 0.243291221880861 no 838 0.276543717449342 1475 3125502 SGTC_1846 st056244 14.8 µM 0.590557633139479 0.244072989304185 no 839 0.277408429520611 1386 5393182 SGTC_1864 st057645 30.4 µM 0.590048990729895 0.244227129163346 no 840 0.277578902651496 1361 688666 SGTC_2050 5263056 171 µM 0.58942578858305 0.244416056918553 no 841 0.277787840598018 1343 763468 YGL055W OLE1 SGTC_1158 4092-0494 91.8 µM 0.584205400097816 0.246001739679291 no 842 0.27954106441266 1455 1148199 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.582461594043898 0.24653264449163 no 843 0.280127901818364 1357 16623 A steroid. SGTC_891 0929-0073 133 µM 0.5824328314458 0.246541406457976 no 844 0.280137586204917 1424 5603632 SGTC_2928 9011484 9.79 µM 0.582049269168519 0.246658267193845 no 845 0.28026674739268 1357 2994751 SGTC_2194 5927483 104.545 µM 0.579729959138515 0.247365527904898 no 846 0.281048368390814 1373 760979 SGTC_3333 9141820 12.094 µM 0.57732812898207 0.248099093655754 no 847 0.281858907562584 1366 1939433 SGTC_507 nimesulide 162 µM 0.576334778359664 0.248402821167461 no 848 0.282194459876401 1422 4495 A COX2 inhibitor. SGTC_802 4112-3352 742 µM 0.575532207302427 0.248648360466985 no 849 0.282465707501849 1465 704594 SGTC_3020 9089140 49.47 µM 0.571463563101141 0.249895111332711 no 850 0.283842726361199 1390 17217859 SGTC_2935 9038016 29.96 µM 0.571402916466429 0.24991372029034 no 851 0.28386327629336 1349 6463195 SGTC_1214 0358-0031 63.7 µM 0.570842697621633 0.250085653944618 no 852 0.284053138452239 1571 4301366 SGTC_2069 5228469 200 µM 0.570831139249163 0.250089201921093 no 853 0.284057056306559 1329 2835210 SGTC_1445 4239-0156 97.7 µM 0.570566976583468 0.250170296993435 no 854 0.284146604578288 1516 4008346 SGTC_1106 tegaserod maleate 11.7 µM 0.567829574025036 0.25101147032159 no 855 0.28507534816974 1417 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1769 st044406 64.4 µM 0.566103896264544 0.251542519982737 no 856 0.285661577405361 1396 670903 SGTC_2977 9011197 71.43 µM 0.56554631847563 0.251714232403615 no 857 0.285851114443475 1446 2704722 SGTC_1461 k072-0203 53.8 µM 0.564787764793097 0.251947936989844 no 858 0.286109065052546 1329 5418714 SGTC_2611 pyromycin 23.93 µM 0.564270466785018 0.252107378197241 no 859 0.286285038659675 1350 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1924 st058459 75.1 µM 0.56088933988676 0.253150816084614 no 860 0.287436488781118 1355 688683 SGTC_3320 9137005 35.139 µM 0.560755661699689 0.253192116674789 no 861 0.287482058154297 1387 4908713 SGTC_686 1319-0111 510 µM 0.560442147801717 0.253288992367532 no 862 0.287588944875009 1477 4562600 SGTC_795 0685-0265 78 µM 0.55829498680253 0.2539529878258 no 863 0.288321483830333 1412 302754 SGTC_476 mead acid 10 µM 0.557385626069656 0.254234476765749 no 864 0.288631992058458 1429 5312531 An omega 9 fatty acid. SGTC_2889 9059656 51.95 µM 0.557247231876809 0.254277330467919 no 865 0.288679261628471 1469 3949838 SGTC_1862 st057513 3.81 µM 0.556524235062165 0.254501267675759 no 866 0.28892626584516 1378 5393163 SGTC_755 1995-0008 37.3 µM 0.554044086130717 0.25527024037283 no 867 0.289774337329983 1392 689533 SGTC_348 k064-0012 10.7 µM 0.553335366615231 0.255490202512195 no 868 0.290016893942836 1358 5066323 SGTC_1861 st057647 17.4 µM 0.552670136052187 0.255696757240098 no 869 0.290244653187003 1508 688668 SGTC_1268 0828-0275 2.46 µM 0.552494696950016 0.255751245776202 no 870 0.290304733354113 1443 745337 SGTC_848 0368-0089 85.6 µM 0.55187582353902 0.255943506205649 no 871 0.290516716743784 1367 762535 SGTC_1587 estradiol valerate 56.1 µM 0.55147640839205 0.256067629329771 no 872 0.290653567305253 1417 13791 A steroid. SGTC_2158 5657123 3.6195 µM 0.548560170882986 0.256974836284596 no 873 0.291653662731105 1410 2858827 SGTC_739 1486-1183 203 µM 0.548549206781169 0.256978250239155 no 874 0.291657425788668 1437 4346692 SGTC_552 k242-0005 476 µM 0.548374086201953 0.257032781724946 no 875 0.291717533079016 1412 4088318 SGTC_3223 9129970 49.47 µM 0.548069541244193 0.257127629510457 no 876 0.291822076929616 1466 17248386 SGTC_2932 9016711 44.54 µM 0.542770728015844 0.258780805738326 no 877 0.293643834912602 1497 7117328 SGTC_3134 9127454 49.47 µM 0.542216855264815 0.258953925436734 no 878 0.293834562596102 1482 24262820 SGTC_221 trifluoperazine 10.304 µM 0.541801695193297 0.259083728060921 no 879 0.293977561733043 1393 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1876 myriocin 605 nM 0.54100835883402 0.259331863613534 no 880 0.294250910643331 1513 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1226 3909-7979 35.4 µM 0.539770292721387 0.259719344580126 no 881 0.294677728332439 1477 6615510 SGTC_72 0744-0168 198.391 µM 0.539180022010069 0.259904188366953 no 882 0.294881321962613 1461 677577 SGTC_613 3914-0030 117 µM 0.538282256739409 0.260185454379166 no 883 0.295191099514574 1329 1145395 SGTC_2888 9058547 12.99 µM 0.537817687722489 0.260331063432155 no 884 0.295351459741771 1361 16476514 SGTC_246 cycloheximide 667 µM 0.536942898517571 0.260605360988082 no 885 0.295653528782541 1363 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2284 7945075 39.21 µM 0.536882979146252 0.260624154656636 no 886 0.295674224433134 1503 1245402 SGTC_2539 epi(13)torulosol 80 µM 0.535776338318842 0.260971377151437 no 887 0.296056568577023 1409 6708597 SGTC_308 4092-1169 104 µM 0.534531661717944 0.261362194142925 no 888 0.296486874986759 1450 2268590 YDL196W YDL196W SGTC_2206 7254556 146.969 µM 0.534459966095155 0.261384715061269 no 889 0.296511670141876 1447 4398905 SGTC_2732 terfenadine 20 µM 0.533724532690084 0.261615785799386 no 890 0.296766066668317 1432 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2710 st078562 53.7235 µM 0.533332421363717 0.261739028714813 no 891 0.296901744194564 1391 17250908 SGTC_1935 st074532 41.6 µM 0.529518395632234 0.262939351629874 no 892 0.298222943386867 1549 2829742 SGTC_52 0329-0193 875 nM 0.529486234812838 0.262949485004767 no 893 0.298234095444685 1515 3739292 SGTC_2521 angolensin 13.4 µM 0.529355808407761 0.262990582386587 no 894 0.298279323938354 1473 821428 A flavenoid. SGTC_120 rhodamine 6G 52.259 µM 0.528506348445803 0.263258327664788 no 895 0.298573970991778 1418 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2332 7982454 138.89 µM 0.528005129209519 0.263416374594926 no 896 0.29874788796139 1438 2981748 SGTC_881 0833-0569 170 µM 0.527085208021897 0.263706574678433 no 897 0.299067209160391 1392 5418700 SGTC_2424 5537928 59.2 µM 0.526337505070479 0.263942566547397 no 898 0.29932686441276 1433 5382802 SGTC_2515 chrysin 20.77 µM 0.525756310960681 0.264126078807718 no 899 0.299528766644509 1501 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_113 0099-0221 2.5 µM 0.525629167753304 0.264166232986698 no 900 0.299572943415445 1532 89219 SGTC_1070 indatraline 8.81 µM 0.52555152385048 0.264190755897938 no 901 0.299599922768885 1413 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2649 anisomycin 9.56 µM 0.525488471524935 0.264210671084603 no 902 0.299621832716848 1418 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1067 clotrimazole 1.36 µM 0.522859372850873 0.265041756512232 no 903 0.300536059319197 1450 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3295 9122362 53.5725 µM 0.5215796009042 0.265446785772019 no 904 0.300981534705286 1438 4730473 SGTC_2315 7733312 200 µM 0.520888816520505 0.265665539448732 no 905 0.301222113253988 1429 726316 SGTC_3010 9080089 71.4286 µM 0.518751780106314 0.26634286234234 no 906 0.301966923923869 1522 17027233 SGTC_2253 7938677 135.83 µM 0.517687049913055 0.266680649044489 no 907 0.302338317539062 1561 2301972 SGTC_1723 st034307 2.5525 µM 0.515161707479472 0.267482681431189 no 908 0.303220012504715 1465 867466 SGTC_934 2950-0684 338 µM 0.514184427312507 0.267793385400156 no 909 0.303561527172051 1573 1121253 SGTC_1719 st032227 49.2 µM 0.513620879198784 0.267972635307664 no 910 0.303758539479686 1430 3125804 SGTC_1360 1598-0022 39.8 µM 0.513072978320024 0.268146966142895 no 911 0.303950136308699 1537 761525 SGTC_2129 girgensonine 121.053 µM 0.512004201837986 0.268487193104533 no 912 0.304324034418647 1547 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2749 bexarotene 57.39 µM 0.51179288001151 0.268554489531489 no 913 0.304397986965055 1429 82146 An retinoic acid receptor inhibitor. SGTC_2414 st077232 92.9 µM 0.511449787087399 0.268663767136651 no 914 0.304518070136125 1409 729801 SGTC_530 4358-1714 28 µM 0.511389612277366 0.268682935556433 no 915 0.30453913360567 1505 1564641 SGTC_2839 9003951 25.97 µM 0.51045179527125 0.268981761795346 no 916 0.304867488920008 1475 2990634 SGTC_2105 5350118 200 µM 0.50766865356534 0.269869563837943 no 917 0.305842867565809 1449 2133313 SGTC_605 1315-0399 119 µM 0.506707631743382 0.270176463202388 no 918 0.306179987464133 1530 24020461 SGTC_300 r073-0011 5.04 µM 0.506387503644114 0.270278733870578 no 919 0.306292322687903 1496 2735780 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.50630410949882 0.27030537880488 no 920 0.306321589276231 1379 641818 YHR062C RPP1 SGTC_1433 4060-0023 7.6 µM 0.505706901516111 0.270496228738125 no 921 0.306531211316821 1516 3840627 SGTC_1877 wortmannin 25 µM 0.503656038618961 0.271152135778146 no 922 0.307251552922679 1495 312145 A covalent inhibitor of PI 3-kinase. SGTC_21 0849-0113 22.993 µM 0.502398786420427 0.271554621951819 no 923 0.307693516269309 1448 1560156 SGTC_1151 3909-8316 15.3 µM 0.501988618799123 0.271685993910326 no 924 0.307837763414239 1486 800431 SGTC_809 3998-0021 90 µM 0.501497577647931 0.271843310326589 no 925 0.308010491107364 1464 715485 SGTC_1938 st074717 56.4 µM 0.500982122452269 0.272008497093599 no 926 0.308191852403007 1407 17250979 SGTC_3160 9100216 49.47 µM 0.500649067318936 0.272115257063566 no 927 0.308309061720542 1474 17191039 SGTC_2919 7978188 46.38 µM 0.499375344261825 0.272523737797146 no 928 0.308757492685347 1567 2980291 SGTC_1889 st059080 5.18 µM 0.49581380852666 0.273667529363253 no 929 0.31001289077605 1596 176925 Isolated from Daphnopsis sellowiana. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.495751184901031 0.273687662244739 no 930 0.310034984728754 1465 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_260 nsc-65238 3.989 µM 0.494915438485059 0.273956416637828 no 931 0.31032990620447 1542 3246252 SGTC_2082 5219693 150 µM 0.492048359236538 0.274879385194068 no 932 0.311342578671787 1475 2834649 SGTC_385 1494-0393 12.4 µM 0.491819053418241 0.274953269327796 no 933 0.311423632918509 1522 3090647 SGTC_3092 9117248 49.47 µM 0.490319908549176 0.275436546531943 no 934 0.311953770688103 1585 17141857 SGTC_394 menadione 8.33 µM 0.490130565073063 0.275497614630414 no 935 0.312020755357209 1494 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3208 9114115 49.47 µM 0.48952994632693 0.27569137354719 no 936 0.312233279369942 1419 650895 SGTC_1026 k007-1105 30.6 µM 0.481524440073671 0.278280318558577 no 937 0.315071906938511 1491 7066794 SGTC_332 4112-0506 40.9 µM 0.481093469402212 0.278420028059468 no 938 0.315225034658759 1534 2790355 SGTC_2287 7945887 168.79 µM 0.477461307106302 0.279598836723749 no 939 0.316516833607295 1557 1245853 SGTC_1686 st019653 115.5 µM 0.476919592639627 0.279774856121146 no 940 0.316709689866989 1593 97252 SGTC_2963 9082507 9 µM 0.476687381704961 0.279850324928149 no 941 0.316792374754124 1582 16459611 SGTC_1672 st016598 6.51 µM 0.474347944511649 0.280611194913023 no 942 0.317625903700339 1475 4665860 YNL267W PIK1 SGTC_3279 9140807 49.47 µM 0.473965116997313 0.280735799562451 no 943 0.317762391303035 1516 45595718 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.473713195812022 0.280817810749174 no 944 0.317852221031591 1558 364106 SGTC_1516 st013856 110 µM 0.473472496501261 0.280896179552583 no 945 0.317938059293858 1503 5281404 A mutagen and neurotoxin. SGTC_1014 4130-3005 69.3 µM 0.47335817339046 0.280933405486523 no 946 0.31797883266382 1490 743608 SGTC_1563 conessine 56.1 µM 0.469800852976297 0.282092931328176 no 947 0.319248652471836 1581 441082 An anti-amoebic, histamine inhibitor. SGTC_956 1185-0240 191 µM 0.469593769520882 0.282160502097441 no 948 0.319322638447825 1527 1416193 SGTC_2953 9074162 66.49 µM 0.469161012537441 0.282301734675141 no 949 0.319477275415285 1662 16451992 SGTC_2417 cerulenin 830 nM 0.468607803784069 0.282482326856018 no 950 0.319674999112115 1558 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3127 9126946 49.47 µM 0.465951684342154 0.283350176347481 no 951 0.32062504238846 1468 27243249 SGTC_314 1671-0008 2.74 µM 0.465186692674207 0.283600363479714 no 952 0.320898883774375 1481 3913060 SGTC_2304 7443016 91.4 µM 0.464154931693506 0.283937963868137 no 953 0.321268373990569 1507 939854 SGTC_752 1896-0090 130 µM 0.463821507822096 0.284047103910684 no 954 0.321387816300986 1533 772567 SGTC_1402 3909-7673 35.9 µM 0.463430003392423 0.284175281144484 no 955 0.321528088367796 1490 5328014 SGTC_430 0958-0115 16.4 µM 0.461478458214252 0.284814622681847 no 956 0.322227686533407 1547 6833180 SGTC_2467 5474540 200 µM 0.46066265719973 0.285082088778787 no 957 0.322520325275409 1493 5413519 SGTC_1799 st045822 46.1415 µM 0.459960002682548 0.285312554941072 no 958 0.3227724650313 1617 3674992 SGTC_1893 st059353 36.1 µM 0.459564555826846 0.285442297984377 no 959 0.322914402583933 1498 3112488 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.458082997041687 0.285928635544596 no 960 0.323446407011282 1591 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_544 k015-0020 52.4 µM 0.455775185476364 0.286686983172626 no 961 0.324275824948358 1557 3008304 SGTC_458 nppb 133 µM 0.45557883322882 0.28675154858207 no 962 0.324346433475953 1664 4549 A chloride channel blocker. SGTC_3336 9143619 71.43 µM 0.45467002673778 0.287050476080876 no 963 0.324673323732114 1581 45595730 SGTC_299 1273-0059 1.44 µM 0.454418292520258 0.28713330338688 no 964 0.32476389437284 1554 2848077 SGTC_1591 genipin 88.4 µM 0.453901832545631 0.287303267974883 no 965 0.324949742267566 1604 442424 A DNA cross-linking agent. SGTC_1038 k292-0204 154 µM 0.452850234744085 0.287649491019098 no 966 0.325328293915766 1495 4454212 SGTC_3273 9137859 49.47 µM 0.452806554347191 0.287663876409024 no 967 0.325344021782765 1596 2377234 SGTC_2861 9024595 19.48 µM 0.452409809265926 0.287794553166299 no 968 0.325486890813302 1539 16482810 SGTC_889 0919-1524 82.7 µM 0.449745491518339 0.288672830708702 no 969 0.326446982711364 1525 3905452 SGTC_938 3126-1755 342 µM 0.449634706797006 0.288709377595987 no 970 0.326486929158858 1587 1777771 SGTC_990 3985-0011 41.3 µM 0.449215092161911 0.288847824457831 no 971 0.326638250678971 1556 5399565 YGL099W LSG1 SGTC_1177 0983-0204 23.6 µM 0.448117815233087 0.289210005561138 no 972 0.327034085697181 1652 766818 SGTC_1691 st019933 84.6 µM 0.448031462575091 0.289238517271014 no 973 0.327065245086149 1610 6176082 SGTC_1806 st050005 60.3 µM 0.446226197047674 0.289834877748865 no 974 0.327716930681222 1525 5194765 SGTC_2716 st080858 38.6235 µM 0.445477218913938 0.29008246812663 no 975 0.327987459698278 1592 5296050 SGTC_571 k831-0106 44.2 µM 0.444607764527727 0.290370008716532 no 976 0.328301617654415 1652 4783639 SGTC_839 0122-0028 230 µM 0.442185584532632 0.291171760093867 no 977 0.329177458335053 1576 759448 SGTC_1880 MG-132 525 µM 0.441281836332281 0.291471168967009 no 978 0.329504487019181 1637 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1485 3909-9022 254 µM 0.440527387066506 0.291721225511765 no 979 0.32977759057351 1560 714516 SGTC_1426 4048-4480 71.7 µM 0.44033846118638 0.291783859225465 no 980 0.329845994187187 1639 14224343 SGTC_602 3130-1533 38.1 µM 0.44020468186361 0.291828214247795 no 981 0.329894434556135 1634 720941 SGTC_531 3788-1495 174 µM 0.439583183147402 0.292034315595146 no 982 0.330119511420485 1552 2896655 SGTC_1081 sertraline 6 µM 0.438000120696862 0.29255959650432 no 983 0.330693097967515 1662 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1035 k081-0041 55.2 µM 0.436725213868232 0.292982946227378 no 984 0.331155320635356 1624 731709 SGTC_2881 9058953 51.95 µM 0.436715877118805 0.292986047667059 no 985 0.331158706662208 1484 17122249 SGTC_728 3030-5151 22.5 µM 0.435428472633484 0.293413837714199 no 986 0.331625723533344 1586 3125388 SGTC_704 1310-0270 142 µM 0.434339224480567 0.293776008474237 no 987 0.332021062055149 1532 5718033 SGTC_1294 1000-1494 117 µM 0.433596542435197 0.294023065890864 no 988 0.332290722998846 1530 712797 YDL207W GLE1 SGTC_1316 1272-0050 65.9 µM 0.432444408419687 0.294406519799127 no 989 0.332709223975314 1578 7340392 SGTC_864 0469-0573 172 µM 0.432259522171778 0.294468075237747 no 990 0.332776401458147 1551 689425 SGTC_1242 0402-0103 60.1 µM 0.431968309527656 0.294565042693504 no 991 0.332882222986669 1532 432868 SGTC_136 0097-0015 404.482 µM 0.431495795927195 0.294722410750859 no 992 0.333053954400204 1609 4861337 SGTC_3072 9116419 49.47 µM 0.426702226512966 0.296321069765258 no 993 0.334798114321504 1529 17170162 SGTC_2992 9074591 71.4286 µM 0.425519986178104 0.2967159582224 no 994 0.335228827585494 1597 17741321 SGTC_1828 st055811 49 µM 0.42520554825969 0.2968210264079 no 995 0.33534341997358 1682 5877589 SGTC_867 0518-0118 155 µM 0.424837719454317 0.29694395655421 no 996 0.335477489349227 1605 6848158 SGTC_2652 actinonin 100 µM 0.424748907523599 0.296973641416917 no 997 0.335509863418874 1598 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_389 tpck 16.7 µM 0.422942624404954 0.297577675208144 no 998 0.336168561462695 1591 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1559 coumarin 343 70.1 µM 0.422035916150851 0.29788109609266 no 999 0.336499401035961 1653 108770 A hepatotoxic, DNA x-linker. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.421958888810008 0.297906879024716 no 1000 0.336527512599272 1556 229346 A bile salt which induces apoptosis. SGTC_1227 3909-8010 46.6 µM 0.41907804659232 0.298871896963859 no 1001 0.337579547173907 1611 15982272 SGTC_1605 st000082 49.1 µM 0.418840754712834 0.298951447727314 no 1002 0.337666258882127 1650 1114022 SGTC_1398 3558-0053 112 µM 0.417848018797567 0.299284361071918 no 1003 0.338029119976996 1576 4532369 SGTC_1808 st050063 61.5 µM 0.416706714948127 0.299667304258939 no 1004 0.338446471078231 1671 4011993 SGTC_2323 6148992 148.28 µM 0.416614580032782 0.299698228089452 no 1005 0.338480171568756 1556 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1798 st045719 60.953 µM 0.414769089101727 0.300317946203588 no 1006 0.339155474992898 1615 3980186 SGTC_2296 7971656 126.45 µM 0.41261852921608 0.301040836580927 no 1007 0.339943061742101 1577 666570 SGTC_2742 clothiapine 36.27 µM 0.412151788238535 0.301197830673495 no 1008 0.340114085956568 1693 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1006 4099-6547 255 µM 0.411098097439642 0.301552388131364 no 1009 0.340500302500948 1639 3146833 SGTC_2350 9023895 38.85 µM 0.410863867527784 0.301631229888501 no 1010 0.340586179149134 1682 2997209 SGTC_3329 9141233 27.5565 µM 0.410010598742645 0.301918518417796 no 1011 0.340899086356322 1689 4909101 YNL103W MET4 SGTC_2795 7780010 54.55 µM 0.409543904865128 0.302075702369396 no 1012 0.341070276740577 1621 953673 SGTC_156 3474-0145 5.642 µM 0.409152076305252 0.302207699817518 no 1013 0.341214030663563 1755 2265471 SGTC_462 ag-879 158 µM 0.407599129424137 0.302731104013016 no 1014 0.341784001779117 1689 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1609 st001574 46.4 µM 0.407058325406461 0.302913471520513 no 1015 0.341982575429181 1581 3960012 SGTC_1660 st012960 28.1 µM 0.406765767488194 0.303012147083278 no 1016 0.342090015736789 1618 24207266 SGTC_2052 5265182 7.135 µM 0.406523602418405 0.303093836744354 no 1017 0.342178959217077 1716 1239884 SGTC_413 propylparaben 100 µM 0.406003038429148 0.303269472189047 no 1018 0.342370183947058 1576 7175 A pharmaceutical preservative. SGTC_714 4296-0578 26.1 µM 0.404966174613733 0.303619439859815 no 1019 0.34275118739331 1701 1589775 SGTC_932 2857-0803 154 µM 0.403723568334792 0.304039088139635 no 1020 0.343208003225257 1727 674898 SGTC_741 4582-0002 126 µM 0.400103279144051 0.305263189636161 no 1021 0.344540224550499 1587 2912688 SGTC_2924 9010168 62.78 µM 0.399934597189706 0.305320278096478 no 1022 0.344602344606842 1623 2993929 SGTC_2461 5755302 26.15 µM 0.397795294893506 0.306044710758003 no 1023 0.345390542907589 1744 2788904 SGTC_3058 9093861 49.47 µM 0.397659414547846 0.306090749638447 no 1024 0.345440628962736 1654 17217477 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.397293526406879 0.306214734820741 no 1025 0.345575510292183 1733 5357218 A potent inhibitor of glutathione S-transferases. SGTC_29 0299-0004 12.984 µM 0.396968203311784 0.306324992738469 no 1026 0.345695454155594 1594 16871 A napthoquinone isolated from Swertia calycina. SGTC_2561 acetosyringone 100 µM 0.396528160469004 0.306474159174302 no 1027 0.345857718862053 1608 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_529 4076-0302 30.3 µM 0.396102230381033 0.306618572191928 no 1028 0.346014806493767 1611 5816522 SGTC_2234 tolnaftate 200 µM 0.395733218982085 0.30674371101743 no 1029 0.346150923325617 1663 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3103 9120822 49.47 µM 0.39438752153133 0.307200253560651 no 1030 0.346647477586072 1734 17141819 SGTC_1010 4112-3296 15.2 µM 0.394377325493669 0.307203713819821 no 1031 0.346651240869765 1796 704384 SGTC_2857 9024691 58.44 µM 0.393644310047823 0.307452524382266 no 1032 0.346921831194269 1629 16478292 SGTC_14 0354-0009 295 µM 0.392922129748368 0.307697743799865 no 1033 0.347188498125964 1685 1713507 SGTC_649 1123-0311 367 µM 0.392559085063432 0.307821049645543 no 1034 0.347322581901542 1693 693629 YIL048W NEO1 SGTC_2362 9071156 126 µM 0.392468660165264 0.307851765271009 no 1035 0.34735598162259 1694 653133 SGTC_912 3474-0017 2.18 µM 0.389351896234004 0.308911292796226 no 1036 0.348507925637729 1728 3360550 SGTC_2045 5106652 78.05 µM 0.387465268963779 0.309553416006852 no 1037 0.349205896060876 1712 673349 SGTC_3217 9129673 49.47 µM 0.387290970154428 0.309612768882484 no 1038 0.349270404863122 1650 17248312 SGTC_2621 lithochol-11-enic acid 100 µM 0.3869813438227 0.309718216230663 no 1039 0.349385009750458 1791 6708711 SGTC_358 0075-0058 9.45 µM 0.385981045865186 0.310058987942985 no 1040 0.349755353181249 1889 1069125 SGTC_2663 amphotericin b 100 µM 0.385330447000747 0.310280715212507 no 1041 0.349996303205331 1652 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3140 9094243 49.47 µM 0.384844844250844 0.310446255963058 no 1042 0.350176186110731 1661 19291112 SGTC_2014 4013930 200 µM 0.381100429885034 0.311724005004167 no 1043 0.35156436422053 1679 64556 SGTC_1343 1487-0095 224 µM 0.379750651378233 0.31218516270722 no 1044 0.352065258667813 1767 4560101 YGL055W OLE1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.379467599875796 0.312281905854579 no 1045 0.352170329927989 1627 6312947 SGTC_471 1-acyl-paf 4 µM 0.379177072946124 0.312381217461909 no 1046 0.352278187871067 1594 16759367 SGTC_2068 5226020 147 µM 0.378275925506248 0.312689345813246 no 1047 0.352612813854815 1623 1810509 SGTC_1748 st037455 53.6035 µM 0.375598721323346 0.313605531065628 no 1048 0.353607620758159 1705 580690 SGTC_1100 amiodarone 5.07 µM 0.374522968191077 0.313973996747498 no 1049 0.354007635895661 1820 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_894 0960-0238 55.9 µM 0.374026230321599 0.314144201456171 no 1050 0.354192400606349 1694 6741907 YDL195W SEC31 SGTC_1581 himbacine 57.9 µM 0.373911674083436 0.314183459180854 no 1051 0.354235015377897 1637 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1687 st020778 55.3625 µM 0.373127889419911 0.314452113788939 no 1052 0.354526631197541 1686 4259299 SGTC_1499 4480-0877 67.3 µM 0.369827885691929 0.315584319140914 no 1053 0.355755368137071 1682 2861909 SGTC_885 0865-0106 16.8 µM 0.369236521748234 0.315787394895432 no 1054 0.355975717889393 1604 2793380 SGTC_3071 9117417 49.47 µM 0.368887195940469 0.315907380327127 no 1055 0.356105903755404 1788 45595590 YGL055W OLE1 SGTC_1998 st075797 76.8 µM 0.368540069153952 0.316026629661063 no 1056 0.356235286714702 1787 24208315 SGTC_2791 5663188 71.43 µM 0.364741340148943 0.317332865416425 no 1057 0.357652248202457 1775 54690634 SGTC_2009 4012297 12.05 µM 0.362996834543032 0.31793349779761 no 1058 0.358303624479992 1652 45595307 SGTC_3024 9090631 49.47 µM 0.362842654025244 0.317986605143989 no 1059 0.35836121340096 1817 25236383 SGTC_1491 4138-0063 26.5 µM 0.36146895611658 0.318459939347645 no 1060 0.358874453913584 1781 23883227 SGTC_2443 5493264 126.67 µM 0.361233046645291 0.318541256372089 no 1061 0.358962619995201 1782 5340055 SGTC_225 nsc-122657 1.016 µM 0.361189273286506 0.31855634583037 no 1062 0.358978980171398 1730 275685 SGTC_3216 9129716 49.47 µM 0.360560774713885 0.318773033678578 no 1063 0.35921390834377 1608 8056934 SGTC_3157 9099274 49.47 µM 0.359161352896687 0.319255735758938 no 1064 0.359737193132889 1818 17217662 SGTC_2117 5521686 200 µM 0.358273568984995 0.319562117736128 no 1065 0.360069297972318 1649 803312 SGTC_98 0074-0023 107.663 µM 0.35737991829187 0.319870648823136 no 1066 0.360403704173016 1635 3563821 SGTC_1365 1672-3266 55.4 µM 0.355252834796845 0.320605521246023 no 1067 0.361200093118411 1788 6415873 SGTC_2829 7992743 58.44 µM 0.354309935639344 0.32093150272169 no 1068 0.361553311269467 1887 16462845 SGTC_2420 aureobasidin a 50 nM 0.351508087527459 0.32190097875278 no 1069 0.362603603073977 1830 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_822 1487-0950 154 µM 0.350371642078075 0.322294550035995 no 1070 0.363029902794684 1816 1958375 SGTC_1812 st052057 4.327 µM 0.349692968341806 0.322529681908166 no 1071 0.363284565679059 1656 3645418 SGTC_2421 5690543 90.72 µM 0.34767480943568 0.323229308182621 no 1072 0.364042208477729 1725 3397993 SGTC_2891 9063876 19.48 µM 0.346713350261346 0.323562833208076 no 1073 0.364403339802286 1854 6472478 SGTC_2020 4017018 200 µM 0.346603909946906 0.323600806458676 no 1074 0.36444445404874 1693 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1389 3405-0187 19 µM 0.346283261552766 0.323712074587776 no 1075 0.36456492336232 1648 799890 SGTC_1247 0448-0043 5.84 µM 0.344175977594862 0.32444371446922 no 1076 0.365356973529533 1717 3089013 YGL099W LSG1 SGTC_770 0389-1121 67.2 µM 0.342356889602263 0.325075839524047 no 1077 0.366041163746851 1826 6753108 SGTC_1348 1493-0373 93.8 µM 0.342064606011715 0.325177453809288 no 1078 0.366151136418697 1740 3010129 SGTC_1023 4482-3888 16 µM 0.339771749119159 0.325975030936969 no 1079 0.367014212237061 1818 3303168 SGTC_47 0149-0135 24.25 µM 0.338505241469377 0.326415931332949 no 1080 0.367491238933964 1605 5239155 SGTC_232 clozapine 119 µM 0.3379142508698 0.326621751799018 no 1081 0.367713903989455 1751 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1617 st002906 78 µM 0.337319567722463 0.326828911524706 no 1082 0.367938005159805 1709 5150859 SGTC_2316 5844804 197.44 µM 0.336826372041559 0.327000758279278 no 1083 0.36812389576903 1861 776813 SGTC_1156 4092-0367 4.88 µM 0.336215598350035 0.327213624208194 no 1084 0.368354145559824 1742 1357585 SGTC_814 3342-0569 96 µM 0.333322996116426 0.328222512106999 no 1085 0.369445241280767 1736 4346283 SGTC_619 1652-1634 108 µM 0.332980603470194 0.32834201569375 no 1086 0.369574462339132 1717 5400454 SGTC_67 0335-0847 266 µM 0.331535068771711 0.328846736925888 no 1087 0.370120178135177 1931 4552207 YOR254C SEC63 SGTC_235 0330-0087 5 mM 0.331437601363968 0.328880779781909 no 1088 0.370156983290065 1727 46494818 YHR062C RPP1 SGTC_1438 4092-1045 4 µM 0.330672522069195 0.329148051570702 no 1089 0.370445929977885 1718 1351342 SGTC_1590 st077108 57.8 µM 0.329792883473552 0.329455451303511 no 1090 0.370778232496752 1856 5489485 SGTC_583 1488-1091 88.9 µM 0.327019753779305 0.330425306940766 no 1091 0.371826472281306 1876 4303273 SGTC_1138 3761-0006 1.03 µM 0.324549713550581 0.331290122458425 no 1092 0.372760945632312 1777 12061087 SGTC_2154 5570129 200 µM 0.323366515914547 0.331704705329636 no 1093 0.373208842454372 1756 673366 SGTC_1032 k061-1018 98.7 µM 0.322803677694725 0.331901991696685 no 1094 0.373421963799333 1891 4005393 SGTC_516 3992-2719 87.3 µM 0.319781505386931 0.332962121271023 no 1095 0.374566984299422 1624 5350887 YDR037W KRS1 SGTC_3087 9117406 49.47 µM 0.317408900894608 0.333795329929878 no 1096 0.375466677104135 1753 42546093 SGTC_3165 9101544 49.47 µM 0.317369356770344 0.333809223952469 no 1097 0.37548167801098 1819 5002184 SGTC_2447 5741742 33.78 µM 0.317334919286941 0.333821323917298 no 1098 0.375494741887216 1810 1776504 SGTC_2945 9067681 61.76 µM 0.316546733621203 0.334098308292248 no 1099 0.375793779505249 1782 16456930 SGTC_575 k072-0246 11.9 µM 0.31496105634323 0.334655821045624 no 1100 0.376395611309377 1769 6796779 SGTC_2691 st077356 60.2 µM 0.314839793863241 0.3346984710912 no 1101 0.376441647957593 1845 2839272 SGTC_2514 salinomycin 42.74 µM 0.312385999340914 0.335561969300955 no 1102 0.377373594640777 1915 23682228 A polyether potassium ionophore. SGTC_1958 st076513 41.9 µM 0.312383686735182 0.335562783525041 no 1103 0.377374473302089 1733 732122 YGL099W LSG1 SGTC_1399 3562-5772 25 µM 0.312041247379044 0.335683358369596 no 1104 0.377504588179123 1751 23847490 SGTC_937 3122-0005 46.7 µM 0.310736009468867 0.336143095120709 no 1105 0.378000659929126 1890 759535 SGTC_1149 3909-7961 23.3 µM 0.309270924386482 0.336659426031743 no 1106 0.378557723245662 1697 735261 SGTC_1457 k015-0032 57.3 µM 0.308671667378185 0.33687070732109 no 1107 0.378785649103416 1745 4302660 SGTC_2352 9027995 87.8 µM 0.306926680261649 0.337486234102652 no 1108 0.379449590334247 1816 2997347 SGTC_2142 5622915 118.518 µM 0.306208443848593 0.337739711320489 no 1109 0.379722971871875 1751 5322196 SGTC_1741 st038134 10.228 µM 0.306142296941335 0.337763059335013 no 1110 0.379748152322482 1876 1272587 SGTC_768 0384-0033 77.3 µM 0.305859384526301 0.337862926576509 no 1111 0.379855855659573 1707 3965305 YMR134W ERG29 SGTC_1234 0326-0494 15.5 µM 0.305611340581992 0.337950494742996 no 1112 0.379950292412929 1862 1547813 SGTC_567 1080-0542 68.4 µM 0.30298984500802 0.338876509493741 no 1113 0.380948800293499 1893 5950415 SGTC_2437 5741531 144.16 µM 0.302176900462489 0.339163871528981 no 1114 0.381258606199152 1900 2262990 SGTC_1077 5-fluorocytosine 377 nM 0.301631468848496 0.339356724773964 no 1115 0.381466507992469 1787 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.301087133723529 0.339549232281435 no 1116 0.381674025941453 1952 551469 SGTC_3066 9117245 49.47 µM 0.300365833756652 0.339804389003673 no 1117 0.381949060933026 1865 17176980 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.30012047779576 0.339891199346342 no 1118 0.382042629878183 1894 688798 SGTC_2488 5268135 45.7 µM 0.299496717652024 0.340111932562171 no 1119 0.382280538049364 1862 1270356 YLR208W SEC13 SGTC_2724 maprotiline 69.64 µM 0.299451107960057 0.340128074850179 no 1120 0.382297935773337 1843 4011 A tricyclic antidepressant. SGTC_1832 st054113 55 µM 0.298911664705877 0.340319018080319 no 1121 0.382503723318352 1904 1251267 SGTC_1994 st072947 40.9 µM 0.298264107912322 0.340548283637037 no 1122 0.382750797986153 1831 5286565 YDL195W SEC31 SGTC_3112 9123419 49.47 µM 0.298240424764852 0.340556669702513 no 1123 0.382759835173372 1816 17015854 SGTC_1839 st053978 48 µM 0.296341497354169 0.341229325137079 no 1124 0.383484649018919 1863 3788398 SGTC_365 0121-0052 13.6 µM 0.296298820183292 0.341244448442821 no 1125 0.383500943440026 1829 3101739 SGTC_2647 atorvastatin 60.16 µM 0.296274202960456 0.341253172046773 no 1126 0.383510342549346 1857 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2504 purpurogallin 52.29 µM 0.293222791256949 0.34233515635794 no 1127 0.384675932216941 1756 5281571 An antioxidant. SGTC_3353 9151644 39.2805 µM 0.291883215059905 0.342810559478248 no 1128 0.385187958696021 1799 4909158 SGTC_3158 9100007 49.47 µM 0.290238078229001 0.343394743883025 no 1129 0.385817053554163 1741 19297233 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.290031853247805 0.343468000343832 no 1130 0.385895934525992 1844 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2025 5147754 141 µM 0.289997231224652 0.343480299560771 no 1131 0.385909177898461 1896 315777 YLR208W SEC13 SGTC_646 4092-0839 27.3 µM 0.2889622462372 0.343848046778787 no 1132 0.386305134402546 1889 877796 SGTC_2290 7904846 200 µM 0.287726202375064 0.344287427152073 no 1133 0.386778165597284 1755 2962154 SGTC_2208 7283366 200 µM 0.284655166500506 0.345380006962372 no 1134 0.387954171037138 1904 898663 SGTC_611 3453-1652 23.7 µM 0.284378903485569 0.345478356178494 no 1135 0.388060012237061 1912 1560575 SGTC_1992 st073643 23.3 µM 0.283303102887175 0.345861438927533 no 1136 0.388472249461444 1783 3161292 SGTC_1634 st006576 41 µM 0.282786934145221 0.346045297953944 no 1137 0.388670085370833 1957 3915356 SGTC_542 3381-0244 89.3 µM 0.282671711697528 0.346086345084888 no 1138 0.388714251497002 1920 1112843 SGTC_2605 digitonin 300 nM 0.281658225508728 0.346447469785401 no 1139 0.389102794646756 1972 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_683 panaxydol 45 µM 0.280623877065088 0.346816172072867 no 1140 0.389499450193963 1900 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2851 9015922 71.43 µM 0.278297378124774 0.347646002200354 no 1141 0.390392044303984 1897 2996893 SGTC_2072 5231554 129 µM 0.278159464771205 0.347695216968429 no 1142 0.390444974900414 1973 789545 SGTC_499 genistein 192 µM 0.277967857582803 0.347763596792549 no 1143 0.390518516347126 1876 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1941 st076221 61.8 µM 0.277955846760606 0.347767883320241 no 1144 0.390523126394643 1940 2828568 SGTC_803 4488-1585 147 µM 0.27699592969351 0.348110529835503 no 1145 0.390891615773794 1907 747204 SGTC_3290 9121031 71.43 µM 0.275716623548205 0.348567376430311 no 1146 0.391382863308105 1778 17014854 SGTC_801 0866-0028 10.1 µM 0.272946481974731 0.349557360022041 no 1147 0.392447177562462 1826 6849771 SGTC_2667 digitoxin 100 µM 0.272529562706154 0.349706446009791 no 1148 0.392607431721388 1952 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2124 5246320 200 µM 0.272454544786612 0.349733274097723 no 1149 0.392636268814656 1862 579342 SGTC_2266 7929956 200 µM 0.272069702978732 0.349870913941928 no 1150 0.392784212321482 1788 2967153 SGTC_2407 paclitaxel 400 µM 0.271741741636889 0.349988225887176 no 1151 0.392910301679086 1886 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2378 9074213 121.43 µM 0.27034414202791 0.350488308418103 no 1152 0.393447754366262 1809 657714 SGTC_3135 9127742 49.47 µM 0.270088215705469 0.350579910881802 no 1153 0.393546193918083 1788 3643468 SGTC_200 k038-0079 37.545 µM 0.269838864432082 0.350669168327409 no 1154 0.393642110986428 1859 3436683 SGTC_117 lucigenin 22.078 µM 0.268955081543754 0.350985592419905 no 1155 0.393982124547772 1730 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2890 9046729 58.44 µM 0.268563969419953 0.351125656761964 no 1156 0.394132621058611 1762 903329 SGTC_126 0417-1624 672.48 µM 0.268563412422766 0.351125856247182 no 1157 0.394132835397516 1977 41912 YDL195W SEC31 SGTC_2178 5812956 200 µM 0.268346175882713 0.351203661344928 no 1158 0.394216432953324 1858 5403383 SGTC_1783 st039459 87.517 µM 0.267205639706339 0.351612256256765 no 1159 0.394655417060046 1957 729761 SGTC_1178 0988-0033 191 µM 0.266404904853598 0.351899220486384 no 1160 0.394963694077878 1897 5392207 SGTC_1579 chlormadinone acetate 49.4 µM 0.263394391507506 0.352978870337193 no 1161 0.396123306482055 1966 45114258 A steroidal progestin. SGTC_1847 st056231 15 µM 0.262725948944848 0.353218752593273 no 1162 0.396380907409873 1798 5393180 SGTC_2496 diffractaic acid 79.83 µM 0.262017812670821 0.35347294326107 no 1163 0.39665385464485 1959 94870 An apoptosis inducer which activates caspases. SGTC_1681 tripelennamine 100 µM 0.261553761322587 0.353639553328471 no 1164 0.396832748165064 1837 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_788 1182-0090 188 µM 0.260909285052519 0.353870988530863 no 1165 0.397081232175435 1968 5715185 SGTC_197 4544-0043 41.561 µM 0.259177885661064 0.354493011430676 no 1166 0.397748996480469 1854 896523 SGTC_446 go6976 132 µM 0.25680055712981 0.355347723300339 no 1167 0.398666369982679 1986 3501 A protein kinase C inhibitor. SGTC_1224 0823-0416 294 µM 0.253326175846139 0.356598163105055 no 1168 0.400008085123539 1933 3598164 SGTC_508 roscovitine 141 µM 0.252972023453924 0.356725710442131 no 1169 0.400144916116405 1893 160355 A CDKinase inhibitor. SGTC_210 3551-0445 56.827 µM 0.25064794606369 0.357563119622882 no 1170 0.40104315454133 1917 2865180 YOR207C RET1 SGTC_1569 carminic acid 40.6 µM 0.250623426721736 0.357571958071949 no 1171 0.401052633880602 1985 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1554 st069299 38.7 µM 0.249430491479059 0.358002065765256 no 1172 0.401513900769701 1908 24207999 SGTC_15 0266-0086 27.098 µM 0.248034792975975 0.35850550774143 no 1173 0.402053743423362 1996 1712902 YIL048W NEO1 SGTC_3257 9139206 32.98 µM 0.246316633470084 0.359125602299719 no 1174 0.40271856744524 1955 4910041 SGTC_1805 st050013 60.3 µM 0.245347298184272 0.359475605443814 no 1175 0.403093765981737 1942 4037144 SGTC_1201 1889-3372 45.9 µM 0.243306559291401 0.36021285126977 no 1176 0.403883961734617 1869 5392199 SGTC_3195 9113082 49.47 µM 0.241550334391012 0.360847728960999 no 1177 0.404564304958137 2030 17018038 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.241049972921331 0.361028680611476 no 1178 0.404758192701957 1892 1377 SGTC_1830 st055982 50.3 µM 0.240131434240019 0.361360943586094 no 1179 0.405114183010642 2006 455313 An antimicrobial agent. SGTC_2063 5246145 200 µM 0.240045518141598 0.361392027367401 no 1180 0.405147484810609 1932 711240 SGTC_1443 4112-3303 14 µM 0.239492386104783 0.361592168168495 no 1181 0.405361899859442 1866 704433 SGTC_1416 3966-0321 25.3 µM 0.23786291607117 0.36218198230361 no 1182 0.405993709381823 1901 582530 YLR208W SEC13 SGTC_3314 9135860 59.4275 µM 0.235905211099436 0.362891039466795 no 1183 0.406753112246159 2013 25252478 SGTC_672 1441-0018 53.7 µM 0.235766991892252 0.362941118602136 no 1184 0.406806741409667 1853 251141 SGTC_2802 7925815 54.55 µM 0.23559616513807 0.363003015236733 no 1185 0.406873024742267 1854 1262923 SGTC_207 4185-0010 4.486 µM 0.234621868689569 0.363356106008098 no 1186 0.407251117260824 1992 3761753 SGTC_1366 1683-0113 21.9 µM 0.234276932189885 0.363481140878784 no 1187 0.407384996546748 1850 708623 SGTC_1308 1187-1617 41.4 µM 0.23401709530038 0.36357533788391 no 1188 0.407485853492911 1869 2882570 SGTC_3256 9138902 49.47 µM 0.233711911662315 0.363685984688374 no 1189 0.407604319830302 1961 17228773 SGTC_2163 5671233 125 µM 0.233478331086447 0.363770678903504 no 1190 0.407694996964396 1988 701023 SGTC_1484 3473-2379 286 µM 0.231845130457615 0.364363048537067 no 1191 0.408329151432729 2015 671917 SGTC_2043 5101342 149 µM 0.229402299423434 0.365249679573647 no 1192 0.409278124566384 1920 678451 SGTC_487 nimodipine 119 µM 0.227798995995458 0.365831994250614 no 1193 0.409901253628406 2018 4497 L-type voltage-gated calcium channels inhibitor SGTC_999 SEC7.066 22.7 µM 0.226755648911691 0.366211100769956 no 1194 0.410306876202687 1924 740511 YDR170C SEC7 SGTC_3133 9127736 49.47 µM 0.223436973607655 0.367417828610318 no 1195 0.411597715409753 2072 27243420 SGTC_2224 6650123 117.647 µM 0.223090564855876 0.36754386457078 no 1196 0.411732510738955 1910 2908370 SGTC_173 1273-0061 2.693 µM 0.221678403354556 0.368057807215195 no 1197 0.412282121734768 1840 2847414 YPL266W DIM1 SGTC_81 0411-0046 9.971 µM 0.218839692086487 0.369091642958102 no 1198 0.413387463186806 1949 12925265 SGTC_2763 lisinopril 49.32 µM 0.218557486191901 0.369194471979614 no 1199 0.413497386597225 2058 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1452 4194-0072 190 µM 0.217533073146007 0.369567821999757 no 1200 0.413896467692505 2039 1343545 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.216741517218273 0.369856390904686 no 1201 0.414204895460553 1999 688801 SGTC_1073 triclabendazole 3.09 µM 0.216579037406073 0.369915633468702 no 1202 0.414268211861185 1923 50248 An antihelmetic and likely tubulin inhibitor. SGTC_140 0062-0056 502.533 µM 0.214777304300826 0.370572778877147 no 1203 0.414970474257449 1925 3758964 SGTC_1997 st073024 93.8 µM 0.21364248339059 0.370986875715685 no 1204 0.415412933611694 2039 686268 SGTC_2544 sphondin 68.51 µM 0.213177103281643 0.371156736436572 no 1205 0.415594413365553 1994 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1474 0330-0125 5.35 µM 0.213120574633309 0.371177370736955 no 1206 0.415616458519734 1994 X1474 SGTC_1165 k072-0275 30.3 µM 0.212827489386598 0.371284359755255 no 1207 0.415730760741122 2053 6153523 YGL055W OLE1 SGTC_2241 6772625 37.8075 µM 0.212614652344771 0.371362060881029 no 1208 0.41581377091267 2064 2285411 SGTC_40 0327-0103 19.753 µM 0.211675839987199 0.371704858754133 no 1209 0.416179968943909 1886 409036 SGTC_253 dyclonine 31.25 µM 0.210998969051502 0.371952074501195 no 1210 0.416444037912189 1964 3180 An oral anasthetic. SGTC_2298 7976326 193.81 µM 0.210300429899114 0.372207259563161 no 1211 0.416716599889698 2004 2235818 SGTC_2961 9083290 32.55 µM 0.207757589192169 0.373136664282068 no 1212 0.41770912446114 2015 17741490 SGTC_143 4032-1194 15.74 µM 0.206366199031801 0.37364552848882 no 1213 0.418252435905196 1894 1806963 SGTC_1596 piperlongumine 63 µM 0.20543378105437 0.373986659116616 no 1214 0.418616614800291 2064 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2996 9066192 71.4286 µM 0.204971730687971 0.37415573957 no 1215 0.418797105865458 1867 6472854 SGTC_504 lovastatin 124 µM 0.204483137309028 0.374334559380699 no 1216 0.418987984041694 1874 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2819 7996655 46.38 µM 0.203154887101852 0.374820820923543 no 1217 0.419506986190158 2018 6456960 SGTC_3013 9080133 71.4286 µM 0.200037435935294 0.375962875054786 no 1218 0.420725651566714 1999 17050193 SGTC_3095 9117207 49.47 µM 0.199690746031616 0.376089949581608 no 1219 0.420861225803821 2071 17015229 SGTC_1341 1486-1360 280 µM 0.199650858724965 0.376104570600108 no 1220 0.420876824469798 1911 3976547 SGTC_42 0133-0086 60.653 µM 0.199430952782708 0.376185182114199 no 1221 0.420962824968755 1953 162923 Model of phenazepam hydroxylation. SGTC_2360 9040895 200 µM 0.199284797326913 0.37623876170209 no 1222 0.421019985320443 1919 4914414 SGTC_3091 9116372 49.47 µM 0.198707316897888 0.376450485389052 no 1223 0.421245850052817 1978 17169793 SGTC_888 0916-0002 6.97 µM 0.197571254082435 0.376867112562858 no 1224 0.4216902636793 2026 2802138 YIL048W NEO1 SGTC_3185 9108267 49.47 µM 0.197311742207867 0.376962303232365 no 1225 0.42179179551002 1900 4910486 SGTC_559 1550-0661 158 µM 0.196507708545687 0.377257275547992 no 1226 0.422106399872606 1987 5830875 SGTC_1883 5-benzylidenerhodanine 20 µM 0.196463978945021 0.377273320490816 no 1227 0.422123511930532 2068 1273210 SGTC_520 3584-0023 682 µM 0.195562576688566 0.377604103520479 no 1228 0.422476277047781 1897 1340790 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.19405079617776 0.378159075444564 no 1229 0.423068054082875 2089 756377 SGTC_863 0466-0191 129 µM 0.192581094731479 0.378698841331589 no 1230 0.423643525991098 2084 765160 YPR165W RHO1 SGTC_3082 9117008 49.47 µM 0.192522525251226 0.378720356602992 no 1231 0.423666462665069 1938 41448529 SGTC_1213 1315-0166 115 µM 0.192453167767702 0.378745835291647 no 1232 0.423693624415012 1837 768401 SGTC_2979 9012552 45.46 µM 0.192419450493938 0.378758221628068 no 1233 0.423706828891247 2120 17100905 SGTC_2960 9079389 5.97 µM 0.191050301502703 0.379261295591601 no 1234 0.424243091998169 2062 16457355 SGTC_1801 st050089 28.441 µM 0.190192582151632 0.379576556399417 no 1235 0.424579111809171 1998 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_517 1365-0151 113 µM 0.189261607010648 0.379918833513291 no 1236 0.424943892316268 1973 768657 SGTC_2428 5615643 7.78 µM 0.188757038322884 0.380104379747735 no 1237 0.425141622456955 2019 2253075 SGTC_2809 7964133 12.99 µM 0.188258946889268 0.380287571155412 no 1238 0.425336832766328 1960 1253665 SGTC_2886 9058944 51.95 µM 0.187788029239246 0.380460793105343 no 1239 0.425521410054134 2031 4949929 SGTC_58 0957-0393 9 µM 0.186687938872827 0.38086554277133 no 1240 0.425952656614997 1951 6997992 SGTC_2591 skatole 100 µM 0.18595292944915 0.3811360430892 no 1241 0.426240837141943 1971 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1690 st023502 41.2 µM 0.185870805590728 0.381166270161985 no 1242 0.426273038493694 2080 24207482 SGTC_3221 9128209 49.47 µM 0.183440018125701 0.382061290121909 no 1243 0.427226389317807 1974 16460723 SGTC_706 4262-0057 46.9 µM 0.183065335742609 0.382199305009613 no 1244 0.427373377086625 1978 883298 SGTC_3151 9099821 49.47 µM 0.18296597715233 0.38223590642566 no 1245 0.427412357119257 1947 17174189 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.182773967217214 0.382306641444555 no 1246 0.427487687827829 2051 16486 A toxic proline analog. SGTC_1645 Cervolide 78 µM 0.181623889049021 0.382730403751919 no 1247 0.427938949953327 1984 23173 A fragrance. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.181311717476918 0.382845451965573 no 1248 0.428061454620461 1953 6857784 SGTC_2233 sulbentine 40.3845 µM 0.180643368130253 0.383091801255615 no 1249 0.428323756492582 2041 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3303 9125618 40.5795 µM 0.179163825866436 0.383637319146958 no 1250 0.428904533435649 2039 22695467 SGTC_2847 9005661 71.43 µM 0.176396758476545 0.384658175324473 no 1251 0.429991125549069 2118 2991449 SGTC_1931 st074438 57.1 µM 0.17623141074569 0.384719202591722 no 1252 0.430056072373767 2106 2787313 SGTC_1080 nisoldipine 24.4 µM 0.175824206675786 0.384869507436566 no 1253 0.430216025854161 1984 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2379 9035213 200 µM 0.175585574706406 0.384957597951511 no 1254 0.430309767996681 2121 646551 SGTC_1054 3429-0080 167 µM 0.17319092518822 0.385841906109259 no 1255 0.431250678252954 2061 1162877 SGTC_135 0933-0004 26.348 µM 0.172864913844528 0.385962343217907 no 1256 0.431378805554036 1941 21230617 YGL099W LSG1 SGTC_2768 sulfasalazine 50.2 µM 0.172093075291692 0.386247524344829 no 1257 0.431682178332303 2101 5384001 An antioxidant and salicylic acid derivative. SGTC_1193 1488-0126 41.5 µM 0.170551215488603 0.386817399031593 no 1258 0.432288330079724 2028 1384710 SGTC_872 0588-0139 234 µM 0.170490136400218 0.386839979028219 no 1259 0.432312345409605 2105 2047100 SGTC_3188 9110789 49.47 µM 0.170082017470029 0.386990864126864 no 1260 0.432472817721086 2096 849217 SGTC_2869 9037858 32.47 µM 0.169969802749027 0.38703235387446 no 1261 0.43251694248871 2136 27187042 SGTC_1185 1319-0113 81.3 µM 0.169800348327141 0.387095009608307 no 1262 0.432583576490818 2032 4672763 SGTC_707 0865-0008 204 µM 0.169619992169801 0.387161699488246 no 1263 0.432654499452581 2039 723043 SGTC_287 k060-0039 29.6 µM 0.169184956774597 0.387322575225107 no 1264 0.432825580987631 2115 5861974 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.168700944343723 0.387501585372904 no 1265 0.433015937974408 2089 6710655 SGTC_2850 9015429 58.44 µM 0.168577860904607 0.387547111128737 no 1266 0.433064347874216 2004 6457570 SGTC_74 000s-0487 160.283 µM 0.16808686782662 0.387728733646756 no 1267 0.43325747016022 2150 677548 SGTC_495 decylubiquinone 155 µM 0.167530199966372 0.38793467954084 no 1268 0.433476443582527 1960 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.166944922250073 0.388151243987766 no 1269 0.433706693131275 2022 7104 SGTC_1199 1638-0010 4.46 µM 0.166175857578696 0.38843586615489 no 1270 0.434009279067881 1951 3111136 SGTC_3210 9128157 49.47 µM 0.165164228748684 0.388810349805446 no 1271 0.434407359930689 1850 17590849 SGTC_278 4092-0821 23.9 µM 0.16433444358451 0.389117595932219 no 1272 0.434733934102682 2062 877900 SGTC_651 3253-0966 34.4 µM 0.162651296451745 0.389741030826173 no 1273 0.435396498002603 2024 781462 SGTC_3139 9095020 49.47 µM 0.16241359927591 0.389829096370104 no 1274 0.435490081172571 2128 25236292 SGTC_2734 clemastine 41.6 µM 0.162273470773988 0.389881015887781 no 1275 0.435545252513192 2120 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1487 3970-0795 2.82 µM 0.160682543589899 0.390470613643067 no 1276 0.436171719482634 2063 3765103 SGTC_606 k015-0008 38.6 µM 0.160229969917418 0.390638383578765 no 1277 0.436349960901177 2105 1970475 SGTC_3268 9137683 49.47 µM 0.158186927434932 0.391395996380612 no 1278 0.437154752226804 2000 1953228 SGTC_1768 st044301 37.178 µM 0.1571367960691 0.39178557272201 no 1279 0.437568519360386 1997 3931349 SGTC_219 mitoxanthrone 164.414 µM 0.155350086508857 0.392448653101503 no 1280 0.43827266577037 2098 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1092 toremifene 6.32 µM 0.154302072982572 0.392837735429044 no 1281 0.438685781444425 2160 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_827 3253-0474 693 µM 0.153304863135212 0.393208055984462 no 1282 0.43907893289166 2136 5402065 SGTC_1418 3966-3099 2.4 µM 0.152390043660809 0.393547865336195 no 1283 0.439439654686859 2101 740335 SGTC_2394 5221648 200 µM 0.152306499071897 0.393578901987412 no 1284 0.439472599602932 2075 788586 SGTC_3335 9143315 29.6265 µM 0.150715631808972 0.394170034872165 no 1285 0.440100020847949 2007 4899691 SGTC_443 clozapine 122 µM 0.149189493240171 0.394737345149122 no 1286 0.440702055195487 2168 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1694 st024011 44.9 µM 0.149066474879015 0.394783084407125 no 1287 0.440750589725823 2132 2787533 SGTC_1407 3909-7909 12.3 µM 0.14783849492994 0.395239737041739 no 1288 0.441235114283008 2051 4411780 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.147254621523726 0.395456914336957 no 1289 0.441465524356271 2122 4620898 SGTC_2752 diclazuril 33.15 µM 0.146715811054506 0.395657358852055 no 1290 0.441678169121175 2150 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_440 fluspirilene 35.1 µM 0.146665045080098 0.395676245879603 no 1291 0.441698205083215 2086 3396 An atypical antipsychotic. SGTC_1867 st057372 64 µM 0.144997945569228 0.396296611236664 no 1292 0.442356246923587 2142 688837 SGTC_309 k408-0051 1.48 µM 0.144454971064112 0.396498721091143 no 1293 0.442570605659552 2061 3640463 SGTC_666 0272-0154 136 µM 0.144354502108332 0.396536121415617 no 1294 0.442610271242542 2055 6870312 SGTC_1373 2887-0003 58.5 µM 0.143107901119197 0.397000257093683 no 1295 0.443102482491462 2057 776948 SGTC_1489 4065-0444 182 µM 0.142785178940818 0.397120437130773 no 1296 0.4432299213145 2159 2877968 SGTC_1735 st034310 56.75 µM 0.142118830911865 0.397368612521588 no 1297 0.443493072117125 2079 871153 SGTC_2173 5763948 167 µM 0.140773424686901 0.397869823647203 no 1298 0.444024468996994 2155 2867177 SGTC_924 2046-0044 21.3 µM 0.137255081289784 0.399181325291763 no 1299 0.445414587131976 2188 3623589 SGTC_2754 granisetron 64.02 µM 0.137041168558697 0.399261100514433 no 1300 0.445499127131882 2146 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_199 4063-0024 41.6 µM 0.136754359621745 0.399368067775306 no 1301 0.445612480176133 2149 306215 SGTC_1441 4106-0040 13 µM 0.136631686190639 0.399413821937657 no 1302 0.445660964705639 2160 2904180 SGTC_1664 st014217 9.02 µM 0.134303981755332 0.400282259388123 no 1303 0.446581102392219 2194 3982782 SGTC_2650 prasterone 100 µM 0.134083817197199 0.40036442563611 no 1304 0.446668148044662 2160 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1925 st057770 10.1 µM 0.13403638174242 0.400382129305257 no 1305 0.446686902762743 1919 5989122 SGTC_1737 st035557 69.7 µM 0.133387813149496 0.400624205975879 no 1306 0.446943341490237 2182 5716916 SGTC_2986 9022445 71.43 µM 0.131912358349485 0.401175057999845 no 1307 0.447526806751765 2167 6459286 SGTC_908 3448-7491 47.7 µM 0.13089411711535 0.401555326804363 no 1308 0.447929534252593 2086 1203031 SGTC_1943 st076331 65.2 µM 0.129895289912104 0.401928435913085 no 1309 0.448324635411474 2203 24208415 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.128874188479587 0.402309957908433 no 1310 0.448728600467076 2068 4330530 SGTC_384 k007-0144 5.16 µM 0.12863169741691 0.402400575403063 no 1311 0.448824541873846 2081 6824886 SGTC_2107 5363541 170.161 µM 0.128213690833485 0.402556794333933 no 1312 0.448989932887095 2192 244052 SGTC_3159 9100096 49.47 µM 0.127067002954838 0.40298541849694 no 1313 0.449443683775807 2164 25236875 SGTC_3045 9092950 49.47 µM 0.126101458409747 0.403346422963012 no 1314 0.449825806522136 2191 44120432 SGTC_460 trequinsin 123 µM 0.124620322300735 0.403900360380681 no 1315 0.450412069474972 2204 5537 A vasodilator. SGTC_1636 st007707 68.9 µM 0.123707930799142 0.404241686218237 no 1316 0.450773266015402 2157 403051 SGTC_2319 6033012 152.6 µM 0.123108968207444 0.404465797897259 no 1317 0.451010404851107 2096 847246 SGTC_698 k064-0052 127 µM 0.122512786780827 0.404688900090063 no 1318 0.451246459944464 2195 5088751 SGTC_2177 5811945 192 µM 0.121973657602777 0.404890678954419 no 1319 0.451459940329868 2153 5343475 SGTC_2906 7926292 26.41 µM 0.121770924168941 0.404966562161871 no 1320 0.451540220851357 2080 2966319 SGTC_3253 9135987 49.47 µM 0.120810681980198 0.405326029708594 no 1321 0.451920494542024 2146 4182430 SGTC_710 3448-4187 58 µM 0.119911604344379 0.405662672662762 no 1322 0.452276585935065 2134 3946412 SGTC_141 0443-0274 32.331 µM 0.119100845958483 0.405966305958537 no 1323 0.452597730268642 2199 1627241 SGTC_2843 9000894 45.46 µM 0.118914058250851 0.406036266965932 no 1324 0.452671721959204 2214 2242070 SGTC_275 trichlorophene 5.69 µM 0.11777969027411 0.40646120686564 no 1325 0.453121111168784 2111 62616 SGTC_2685 mycophenolic acid 18.85 µM 0.117704946403772 0.406489210166787 no 1326 0.453150723682911 2180 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1633 st005664 67.9 µM 0.117617430012288 0.406521999387969 no 1327 0.453185396828879 2147 2063822 SGTC_2255 7941087 197.44 µM 0.116643073322617 0.406887099759491 no 1328 0.453571451551405 2206 935561 SGTC_3113 9123498 49.47 µM 0.116355309959197 0.406994942822021 no 1329 0.453685476117834 2222 8897275 SGTC_3310 9130229 44.1445 µM 0.114279526839844 0.407773077965667 no 1330 0.454508105689798 2184 7761258 SGTC_3046 9092212 49.47 µM 0.113895026054085 0.407917253286391 no 1331 0.454660504271977 2188 25236637 SGTC_2874 9043904 71.43 µM 0.113863571973191 0.407929048098333 no 1332 0.454672971531279 2070 4463428 SGTC_1071 trifluoperazine 6.31 µM 0.11272146227878 0.40835737866454 no 1333 0.455125692628377 2161 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1212 0520-0165 585 µM 0.110116679123614 0.409334671204666 no 1334 0.456158420285702 2223 5403258 SGTC_2093 5331342 194.4 µM 0.109646438059544 0.409511161911633 no 1335 0.45634489020673 2209 33839 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.109270958634863 0.409652099884764 no 1336 0.456493790146161 2061 2374 Ca(2+)-ATPase inhibitor. SGTC_577 r071-0003 38.6 µM 0.107841031889214 0.41018893638156 no 1337 0.457060896963114 2193 4568517 YMR134W ERG29 SGTC_1519 esterone 74 µM 0.105690877650549 0.410996484044584 no 1338 0.457913809195449 2001 698 A steroid. SGTC_483 fpl-64176 144 µM 0.105648244119732 0.411012500028411 no 1339 0.457930722820121 2208 3423 SGTC_129 0088-0017 176.636 µM 0.104428832372673 0.411470654713031 no 1340 0.458414521420485 2222 182446 SGTC_2222 6885208 172.143 µM 0.102267703762779 0.412282925430494 no 1341 0.459272094767118 2197 609514 SGTC_945 3381-0768 11.3 µM 0.101286405483123 0.412651875468155 no 1342 0.459661553773402 2228 1126236 YIL048W NEO1 SGTC_1415 3966-0071 78.1 µM 0.100519642084423 0.412940218087569 no 1343 0.459965894842386 2225 2893185 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0997418777411297 0.413232745622238 no 1344 0.460274626332454 2088 61125 An anti-inflammatory. SGTC_1784 st039334 36.3 µM 0.0993876516425724 0.413365990755807 no 1345 0.460415243390631 2247 3496984 SGTC_174 3553-0389 74.3 µM 0.0989549963084393 0.413528751243211 no 1346 0.460587001199967 2183 738071 SGTC_3337 9144342 33.5465 µM 0.0987874509566733 0.41359178407433 no 1347 0.460653516219357 2203 17682949 SGTC_276 colchicine 750 µM 0.0981339772482527 0.41383765100109 no 1348 0.460912953892546 2142 2833 A microtubule depolymerizer. SGTC_1068 loratadine 26.9 µM 0.0972736998703024 0.414161378492394 no 1349 0.461254520698854 2117 3957 A H1 histamine antagonist. SGTC_2709 st078560 56 µM 0.096934405754875 0.414289072936653 no 1350 0.461389242806077 2245 17250903 SGTC_1696 st025591 34.7925 µM 0.0964714522014121 0.414463321625822 no 1351 0.461573072998138 2239 2787147 SGTC_1767 st044992 70.3 µM 0.0954324277472687 0.41485445589842 no 1352 0.46198567999641 2168 9600693 SGTC_2094 5332512 191.667 µM 0.0939130062853017 0.41542658452255 no 1353 0.462589130990285 2217 755774 SGTC_353 1988-1175 58.3 µM 0.0937584336091841 0.415484797965911 no 1354 0.46265052567578 2148 2788357 SGTC_1263 0774-1208 64.8 µM 0.0923281006785195 0.416023561899922 no 1355 0.463218681302736 2245 906585 SGTC_560 2332-1943 155 µM 0.0913880458330541 0.416377738670718 no 1356 0.463592130021981 2243 21177716 SGTC_1853 st056710 91.2 µM 0.090719777856312 0.416629557840179 no 1357 0.46385762748809 2271 269167 SGTC_2619 obliquin 87.91 µM 0.0902024181339275 0.416824534717185 no 1358 0.464063181384903 2203 6708593 A bioactive alkalod. YER133W GLC7 SGTC_622 1348-1566 26.3 µM 0.0891759833051256 0.417211426780052 no 1359 0.464471025933143 2201 7340407 SGTC_1602 st001878 87.6 µM 0.0885625091879999 0.417442700677842 no 1360 0.464714802148471 2204 595405 YLR310C CDC25 SGTC_1120 ficusin 1.78878 µM 0.0880694247775909 0.417628609512289 no 1361 0.464910748710429 2161 6199 A DNA cross-linker. SGTC_1357 1503-1303 39.5 µM 0.0875434982568959 0.417826921180669 no 1362 0.465119755758976 2234 292895 SGTC_2096 5468907 200 µM 0.0874836003847361 0.417849508261044 no 1363 0.465143560223242 2232 759785 SGTC_1335 1486-0900 202 µM 0.0870317629168615 0.41801990182571 no 1364 0.465323132366174 2264 X1335 SGTC_2776 terbinafine 19.92 µM 0.0864225452812113 0.418249669779476 no 1365 0.465565262717089 2249 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_679 0422-0091 41.4 µM 0.0856471428768767 0.418542155079862 no 1366 0.465873460759361 2221 627384 YHR062C RPP1 SGTC_554 4483-2211 187 µM 0.0853552536013663 0.418652268714755 no 1367 0.465989482868934 2163 747107 SGTC_2256 7954252 200 µM 0.0799089018735283 0.420708035196361 no 1368 0.468154854900901 2145 2972920 SGTC_747 3448-8087 38.7 µM 0.0789004475010792 0.421088923040863 no 1369 0.468555903649258 2194 5168703 SGTC_1825 st052143 62.6 µM 0.0787832451100784 0.421133194557694 no 1370 0.468602515542382 2258 674173 SGTC_2931 9014674 55.67 µM 0.0776873615869736 0.421547196972123 no 1371 0.469038373856553 2232 2996810 SGTC_2904 7225135 42.03 µM 0.07713883558821 0.421754451493977 no 1372 0.469256549346511 2270 4446116 SGTC_685 1278-0033 54.9 µM 0.0763058852881568 0.42206921404285 no 1373 0.469587871857468 2252 3590572 SGTC_1982 st072467 71.9 µM 0.0737873752282891 0.423021232703723 no 1374 0.470589786374043 2128 3163533 SGTC_771 0250-0039 27.3 µM 0.0734019194341122 0.423166978157393 no 1375 0.470743145115097 2151 3005115 SGTC_1176 0848-0131 83.3 µM 0.0729929051531987 0.423321642855525 no 1376 0.470905881659529 2282 6769040 SGTC_2405 ticlatone 3.52 µM 0.0724631622109893 0.423521977460609 no 1377 0.471116660333813 2307 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2390 9097792 176.6 µM 0.0718984683866517 0.423735551323933 no 1378 0.471341354473663 2134 4497149 SGTC_3048 9093155 49.47 µM 0.0717620528449188 0.423787148652794 no 1379 0.471395636184548 2298 25236002 SGTC_2038 4100038 30.985 µM 0.071533616952746 0.42387355435706 no 1380 0.471486535309083 2212 3596803 SGTC_2971 9092186 9.93 µM 0.0714958332553148 0.423887846365034 no 1381 0.471501570327081 2069 25236400 SGTC_909 3448-9333 149 µM 0.0710888272928265 0.424041806208707 no 1382 0.471663530101271 2230 3344074 SGTC_3193 9111931 49.47 µM 0.0710774767121919 0.424046100006481 no 1383 0.471668046902088 2235 17087244 SGTC_3282 9108498 15.4605 µM 0.0710588407799321 0.424053149790891 no 1384 0.471675462812029 2200 16459645 SGTC_3053 9095903 49.47 µM 0.0704120223282577 0.424297849704252 no 1385 0.471932861282712 2288 17174018 SGTC_441 propafenone 146 µM 0.069213585375554 0.424751311201735 no 1386 0.472409804737659 2278 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2445 5742597 35.57 µM 0.0671095612436628 0.425547667030292 no 1387 0.473247241142653 2216 1774255 SGTC_1955 wogonin 32.4 µM 0.0671089373075436 0.425547903230201 no 1388 0.47324748949727 2254 5281703 A flavanone. SGTC_944 3370-0224 231 µM 0.0668438762405023 0.425648248290047 no 1389 0.473352996653846 2247 4580514 SGTC_1567 st069303 68.4 µM 0.0661708881131406 0.425903045290163 no 1390 0.473620886940943 2199 5581319 SGTC_2943 9068529 45.32 µM 0.0640116555995288 0.426720750941217 no 1391 0.474480473008244 2294 3270634 SGTC_1245 0418-0076 17.2 µM 0.0637137807106392 0.426833581562185 no 1392 0.47459906581129 2225 6790114 SGTC_1220 1838-0075 193 µM 0.063517916073795 0.426907775465228 no 1393 0.474677046543202 2227 5529645 SGTC_1265 0819-1001 68.8 µM 0.0621532918306159 0.427424769397233 no 1394 0.475220379125549 2297 3106768 SGTC_119 0121-0043 24.815 µM 0.0621465279835296 0.427427332221819 no 1395 0.475223072303754 2284 1092378 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0619197381801607 0.427513264748527 no 1396 0.475313374431391 2272 390807 SGTC_2067 5224629 34.075 µM 0.0602684014007252 0.428139073304913 no 1397 0.475970934105579 2218 2835000 SGTC_1704 st028805 70.8 µM 0.0596694967745131 0.428366085474799 no 1398 0.476209433239326 2198 2876101 SGTC_2933 9026794 32.47 µM 0.0589701714313324 0.428631191674121 no 1399 0.476487933250633 2259 17586027 SGTC_2909 7941780 10.49 µM 0.056742217729227 0.429475997490371 no 1400 0.477375271643163 2304 1243215 SGTC_317 4495-0002 170 µM 0.0558680526490829 0.429807555924939 no 1401 0.477723460678623 2179 15991618 SGTC_121 0557-0495 61.343 µM 0.055670299132163 0.429882567908569 no 1402 0.477802230327477 2296 3104427 SGTC_5 0352-0601 109.883 µM 0.055193671957952 0.430063372813481 no 1403 0.477992085149352 2238 762456 SGTC_2820 7989630 71.43 µM 0.0546605837591051 0.430265613153739 no 1404 0.47820443599669 2305 2984098 SGTC_3069 9117009 49.47 µM 0.0538149348925499 0.430586468709274 no 1405 0.478541305219417 2313 41904981 SGTC_629 3448-6466 76.7 µM 0.052498067956455 0.431086204701416 no 1406 0.47906591738058 2303 573744 SGTC_1175 0741-0056 27.6 µM 0.0521429155629384 0.431220999913448 no 1407 0.479207408891176 2310 765927 SGTC_2949 9072542 2.23 µM 0.0520719651048588 0.431247929545248 no 1408 0.479235675627937 2257 16457352 SGTC_2993 9054257 71.4286 µM 0.0512300325517263 0.431567513984228 no 1409 0.479571110371467 2313 6470217 YGL055W OLE1 SGTC_2269 7935389 174.42 µM 0.0505566035658601 0.431823169359984 no 1410 0.479839421955693 2313 97605 SGTC_2302 7771753 200 µM 0.0499667986177 0.432047101813767 no 1411 0.480074423061323 2254 2203047 SGTC_955 1216-0110 33 µM 0.0494099158285228 0.432258554685488 no 1412 0.480296313063393 2296 3619719 SGTC_981 1488-1094 54.9 µM 0.0490704774958679 0.432387451671912 no 1413 0.480431565299721 2317 3449522 SGTC_288 1315-0019 35.1 µM 0.048612007775497 0.432561560594102 no 1414 0.480614250229432 2273 6811474 SGTC_415 dibenzyl ketone 100 µM 0.0485035511704042 0.43260275010011 no 1415 0.480657467175017 2300 7593 SGTC_633 0437-0093 97.7 µM 0.0483596814102974 0.432657389897348 no 1416 0.480714795630275 2307 2831118 SGTC_480 am 92016 50 µM 0.0481993802508859 0.432718271635429 no 1417 0.480778672051702 2202 2129 K+ channel blocker. SGTC_280 3448-3607 3.04 µM 0.0475860786481669 0.432951215860121 no 1418 0.481023063545017 2323 626179 SGTC_2765 myclobutanil 7.74 µM 0.0471826576130561 0.433104455953529 no 1419 0.481183824673554 2261 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2167 5876490 200 µM 0.0470645413149915 0.433149324513662 no 1420 0.481230893967976 2281 686534 SGTC_732 3970-1727 52.7 µM 0.0469238345958058 0.433202775568581 no 1421 0.481286965877045 2310 1275699 SGTC_992 3909-8734 162 µM 0.0468123960374915 0.433245109229338 no 1422 0.481331374628225 2298 4288319 SGTC_3356 9151811 4.48 µM 0.0461117988897507 0.433511271996729 no 1423 0.481610570929363 2314 1859254 YPR165W RHO1 SGTC_3233 9132340 49.47 µM 0.0445630250767702 0.434099771086371 no 1424 0.482227807539383 2322 17682950 SGTC_7 0192-1582 4.227 µM 0.0433188170645719 0.434572647932875 no 1425 0.482723695726367 2309 252616 SGTC_3203 9113543 49.47 µM 0.0431829004884003 0.434624310414991 no 1426 0.482777867903232 2266 17018012 SGTC_2938 9059746 27.26 µM 0.0417305112112845 0.435176439426658 no 1427 0.483356765355313 2295 6471769 SGTC_1060 3448-7350 82 µM 0.0384826677856462 0.436411570171755 no 1428 0.48465142517542 2326 570178 SGTC_218 alverine citrate 93.75 µM 0.0384432770181541 0.436426554019511 no 1429 0.484667128198204 2315 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_682 0kpi-0099 17 µM 0.0381754917749495 0.436528419222418 no 1430 0.484773880689264 2283 1714895 YML126C ERG13 SGTC_2084 5306078 60.6385 µM 0.0371381161762783 0.436923075402659 no 1431 0.485187440332725 2299 679340 SGTC_1494 4358-1428 177 µM 0.0367460144289551 0.437072261831522 no 1432 0.485343759594837 2356 1564571 SGTC_1508 1080-0625 72.9 µM 0.0363784733859111 0.437212111557426 no 1433 0.485490289282853 2332 767111 SGTC_2373 9071805 200 µM 0.0361502236080497 0.437298964771022 no 1434 0.485581287913575 2348 10149009 SGTC_2101 5377231 179.231 µM 0.0355256220281705 0.437536652527779 no 1435 0.485830307921532 2298 2844213 SGTC_3150 9097574 49.47 µM 0.034449077519076 0.437946376864852 no 1436 0.486259524236829 2328 17217476 SGTC_1588 farnesol 29.9 µM 0.0343466338611205 0.437985369585766 no 1437 0.486300369172061 2347 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_877 0771-0151 33.1 µM 0.0343100709255734 0.437999286535911 no 1438 0.48631494708085 2254 6166523 SGTC_3239 9133757 49.47 µM 0.0338744529681605 0.43816510169367 no 1439 0.48648863253569 2341 17036923 SGTC_721 1187-1332 279 µM 0.0311663977460425 0.439196147810148 no 1440 0.487568418801559 2332 25730 SGTC_1937 st074714 47.2 µM 0.0304234060818536 0.439479101726821 no 1441 0.487864689069871 2345 17250970 SGTC_742 0kpi-0133 140 µM 0.0303118744039908 0.439521579068727 no 1442 0.487909163260117 2338 2728852 SGTC_1530 rhein 70.4 µM 0.029894320256069 0.439680612626174 no 1443 0.488075667802862 2355 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2190 6049624 200 µM 0.0295313754982088 0.439818855052142 no 1444 0.488220397909597 2333 2265554 SGTC_972 1319-0219 195 µM 0.0292480812893959 0.439926764393374 no 1445 0.488333367147435 2319 23903702 SGTC_2465 5809242 33.21 µM 0.0287507309084019 0.44011622046796 no 1446 0.488531697828373 2360 2731748 SGTC_1361 1608-0041 5.61 µM 0.0278971945812842 0.440441390672448 no 1447 0.488872072986952 2342 X1361 SGTC_2044 5102272 200 µM 0.0278157561607581 0.440472418224133 no 1448 0.488904549613037 2324 592666 SGTC_2203 7227154 166.4 µM 0.0274063047924212 0.440628422283922 no 1449 0.489067834820839 2356 896304 SGTC_2162 5663267 200 µM 0.0266478382644807 0.440917428080221 no 1450 0.489370308686757 2353 6456493 SGTC_3300 9124615 50.48 µM 0.0261732297571583 0.441098288741563 no 1451 0.489559584062348 2346 24824903 SGTC_2128 5255449 168.493 µM 0.0257296063590792 0.441267352912044 no 1452 0.489736504605056 2359 736008 SGTC_429 1112-0049 25.5 µM 0.0244558120743556 0.441752853267434 no 1453 0.490244515009389 2336 2836170 SGTC_2989 9073649 71.4286 µM 0.0228590532470149 0.442361573489724 no 1454 0.490881351314247 2359 21367202 SGTC_1400 3771-8998 51.5 µM 0.0227353783604813 0.442408726823815 no 1455 0.490930677636046 2343 670767 SGTC_2439 5492030 7.2 µM 0.0209949755907849 0.443072373740449 no 1456 0.491624831845692 2360 5722370 SGTC_665 3914-0008 307 µM 0.0206755577911999 0.443194190902689 no 1457 0.491752233454466 2370 1069549 SGTC_1250 0485-0349 40.2 µM 0.0205245742871695 0.443251773727395 no 1458 0.491812454378697 2360 6842794 YDL195W SEC31 SGTC_2435 5706476 10.6 µM 0.0202023231898114 0.443374679428852 no 1459 0.491940987313641 2367 5725375 SGTC_1897 st060201 15 µM 0.0193959699414594 0.443682244233652 no 1460 0.492262612662891 2350 611878 SGTC_717 1532-0246 73.2 µM 0.0186312280868804 0.443973968683743 no 1461 0.492567645372613 2357 9561992 SGTC_3043 9092303 49.47 µM 0.0180816805978049 0.444183622153073 no 1462 0.492786846164339 2372 25236084 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.01732385406126 0.444472760106598 no 1463 0.493089127834314 2368 5282309 SGTC_3342 9147791 14.508 µM 0.0172459986644158 0.444502466404211 no 1464 0.493120183004362 2375 1838168 SGTC_1654 st012436 41.8 µM 0.0169659758731714 0.444609313729557 no 1465 0.493231879591668 2378 4323132 SGTC_3287 9117173 37.0625 µM 0.0165370456026897 0.444772986967546 no 1466 0.493402974003244 2381 2789709 SGTC_195 4234-0266 16.654 µM 0.0159335621999886 0.445003282952091 no 1467 0.49364369731682 2366 2303354 SGTC_373 0844-0104 25.9 µM 0.0150585398428389 0.445337234175745 no 1468 0.493992738810486 2390 5375804 SGTC_1273 0849-0096 14.1 µM 0.0131045109978744 0.446083126614842 no 1469 0.494772206126003 2364 5286025 SGTC_979 1426-2828 121 µM 0.011903398811211 0.44654171037251 no 1470 0.495251343074241 2370 747872 SGTC_922 1866-0035 480 µM 0.0112589433342063 0.446787792517672 no 1471 0.495508426366369 2366 3156169 SGTC_2750 bromebric acid 70.15 µM 0.0107171129831019 0.446994703624949 no 1472 0.495724572350808 2378 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3343 9148379 18.9835 µM 0.00960347177021737 0.447420019870842 no 1473 0.496168827961682 2393 1955036 SGTC_354 2783-3500 4.88 µM 0.00780426737718221 0.448107290513267 no 1474 0.496886579380355 2391 6740761 SGTC_1413 3910-0535 34.4 µM 0.0077612080116522 0.44812374049924 no 1475 0.496903757061588 2385 2876951 SGTC_1192 1488-0095 21.4 µM 0.00599187794089157 0.448799755166881 no 1476 0.497609600853973 2383 915875 SGTC_423 5-fluorouracil 457 µM 0.00445140698186876 0.449388449908612 no 1477 0.498224151412407 2399 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1836 st055642 81 µM 0.00408901361393744 0.449526955656561 no 1478 0.498368724130095 2396 8571 SGTC_2584 androsterone 48.74 µM 0.00303593798553955 0.449929473103272 no 1479 0.498788837837423 2398 2754130 A steroid. SGTC_2540 epiandrosterone 100 µM 0.00253917004290206 0.450119370787731 no 1480 0.498987018801271 2401 441302 A steroid. SGTC_590 k048-0076 22.4 µM 0.00237099356044959 0.45018366159333 no 1481 0.499054111308413 2399 6832814 SGTC_1236 0330-0013 258 µM 0.00220493761507469 0.450247143038978 no 1482 0.499120357872466 2395 4617066 SGTC_3227 9130768 49.47 µM 0.0021447175324124 0.450270164859365 no 1483 0.49914438215275 2402 17720899 SGTC_2135 5326629 150.42 µM 0.00148726222865782 0.450521517428643 no 1484 0.499406668433681 2399 5020077 SGTC_581 0958-0271 211 µM -0.000152556250324085 0.451148524770765 no 1485 0.499939138861842 2406 4591145 SGTC_914 3820-6779 408 µM -0.000328807328227976 0.451215924098607 no 1486 0.499868824857028 2409 2893481 SGTC_824 1304-0008 100 µM -0.000369517082538779 0.451231491920165 no 1487 0.499852584015799 2407 768245 SGTC_492 tmb-8 126 µM -0.000597582717079116 0.451318707910743 no 1488 0.499761599002309 2407 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_681 1642-0006 26.6 µM -0.00128944530322766 0.451583301724383 no 1489 0.499485585892828 2409 4446530 SGTC_727 3032-0951 202 µM -0.00129032148180399 0.451583636821104 no 1490 0.499485236348439 2413 3652836 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.00141403054722577 0.451630950013331 no 1491 0.499435883616923 2414 688761 SGTC_1333 1482-0047 286 µM -0.00155977978444542 0.451686693468401 no 1492 0.499377738148187 2412 3811116 SGTC_2120 5538279 151.968 µM -0.00228824671696875 0.451965318197179 no 1493 0.49908712243326 2412 2058197 SGTC_2372 9071633 200 µM -0.00300816552034226 0.452240696675744 no 1494 0.498799917397427 2412 21321366 SGTC_2862 9027634 71.43 µM -0.00385566126626958 0.452564904460864 no 1495 0.498461817513115 2417 5012562 SGTC_1102 cgs 12066b 26.1 µM -0.00391866497235919 0.452589007667011 no 1496 0.498436682860832 2430 6438352 A 5-HT1B full agonist. SGTC_2003 4023581 200 µM -0.00475159405050178 0.452907676124498 no 1497 0.498104395367002 2419 16641307 SGTC_2171 5739187 198.077 µM -0.00489402195745272 0.452962170338611 no 1498 0.498047575513862 2411 2262761 SGTC_3262 9137218 49.47 µM -0.00517149082419184 0.453068334996651 no 1499 0.497936882853636 2412 17650664 SGTC_1800 st050079 29.0735 µM -0.00542277296333989 0.453164483029127 no 1500 0.497836637190721 2404 3645560 SGTC_884 0851-0618 334 µM -0.00620221571161184 0.453462738487862 no 1501 0.497525689783891 2417 9642473 SGTC_673 1082-0474 110 µM -0.00702909970227034 0.453779176133974 no 1502 0.497195818027243 2420 3098046 SGTC_334 1502-1024 68.5 µM -0.0070828434991626 0.453799744197166 no 1503 0.49717437788808 2439 3296216 SGTC_940 3232-1287 54.8 µM -0.00736730505292708 0.453908611348143 no 1504 0.497060897109501 2419 1585493 YIL048W NEO1 SGTC_2821 7996764 71.43 µM -0.00798086556026178 0.454143440746345 no 1505 0.496816129092874 2421 2987135 SGTC_1965 Pectolinarigenin 58.4 µM -0.00829999964084746 0.454265589996265 no 1506 0.496688817233886 2416 5320438 An anti-inflammatory. SGTC_2214 7179297 48.276 µM -0.00874955735497594 0.454437666505829 no 1507 0.496509476172392 2420 769744 SGTC_1292 0kpi-0043 232 µM -0.0094073390271671 0.454689459978292 no 1508 0.496247070070557 2428 3333905 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.011594674853066 0.455526884717088 no 1509 0.495374497613217 2427 688803 SGTC_1352 1496-0991 99 µM -0.0116468330496249 0.455546855986689 no 1510 0.495353690908279 2435 3000039 SGTC_2899 9053889 58.44 µM -0.0120697787919153 0.455708805213446 no 1511 0.495184971833627 2435 6470052 SGTC_3026 9090633 49.47 µM -0.0126464138751653 0.455929615140598 no 1512 0.494954945287533 2432 25236842 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0126918223658849 0.455947003918574 no 1513 0.494936831374457 2442 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1732 st034308 51.822 µM -0.0130723955934917 0.456092744367884 no 1514 0.494785017221297 2422 830119 SGTC_66 0109-0187 42.4 µM -0.0131224412534937 0.456111909784341 no 1515 0.49476505360395 2425 759417 SGTC_2353 9059630 146.67 µM -0.0134186868145867 0.456225361662828 no 1516 0.494646879130867 2428 4779114 SGTC_1117 retinoic acid 1.10837 µM -0.013927842201751 0.456420359027542 no 1517 0.494443774508747 2433 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3107 9121808 49.47 µM -0.0147581870136611 0.456738388665319 no 1518 0.494112548937436 2437 662681 SGTC_738 1315-0003 72.4 µM -0.0160210966455587 0.457222147635553 no 1519 0.493608780582472 2448 6251474 SGTC_289 k017-0060 526 µM -0.016074552044882 0.457242625190499 no 1520 0.493587457709414 2448 5512909 SGTC_1409 3909-8004 61.9 µM -0.0164847069490437 0.457399750034638 no 1521 0.493423851259222 2447 2119279 SGTC_1831 st055328 12 µM -0.01665683933974 0.457465693630599 no 1522 0.493355189798372 2435 1103068 SGTC_1216 1165-0504 9.65 µM -0.0178289052448655 0.457914740921372 no 1523 0.492887672685632 2444 6304004 SGTC_2071 5230951 39.92 µM -0.0187933797836068 0.458284295171059 no 1524 0.492502967529496 2443 1799272 SGTC_1497 4476-2978 41.3 µM -0.0188884580150107 0.458320727913877 no 1525 0.492465043534789 2489 1528379 SGTC_1772 st048439 82.2 µM -0.0194962926367264 0.458553650504477 no 1526 0.492222597264749 2460 2927068 YDL195W SEC31 SGTC_2814 7977482 42.97 µM -0.0196978044637029 0.458630873102137 no 1527 0.492142221112587 2449 6456762 SGTC_1865 st057639 52.2 µM -0.020317671599966 0.458868426009228 no 1528 0.491894979399224 2445 688818 SGTC_1191 1487-1166 10.6 µM -0.0204861002082212 0.458932975778876 no 1529 0.491827800088952 2490 3955771 SGTC_147 4466-0538 29.23 µM -0.0209095883018784 0.459095281127709 no 1530 0.491658888969108 2510 6742687 YHR072W ERG7 SGTC_2271 7849410 118.62 µM -0.0216232517715192 0.459368814026351 no 1531 0.491374242817531 2436 972430 SGTC_785 1270-0111 65.3 µM -0.0235983917462889 0.460125945467591 no 1532 0.490586477497861 2448 6741994 SGTC_1042 0350-0096 82 µM -0.0245103287244917 0.460475567709544 no 1533 0.49022277253009 2448 3122515 SGTC_2799 7812892 81.82 µM -0.0246195129401049 0.460517429267928 no 1534 0.490179227470447 2464 20205235 SGTC_2425 5628681 7.85 µM -0.0253557824585556 0.460799728629005 no 1535 0.489885590121724 2467 5714958 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0256377820301035 0.460907857724759 no 1536 0.489773125131845 2466 279621 SGTC_3170 9103054 49.47 µM -0.0261360880878166 0.461098933811898 no 1537 0.489574396377444 2472 16432970 SGTC_2786 7743617 45.45 µM -0.0278781890495575 0.46176701492431 no 1538 0.4888796521493 2478 583674 SGTC_1370 2001-0092 44.6 µM -0.027967728498711 0.461801355483695 no 1539 0.488843945000277 2454 790957 SGTC_170 4197-0004 226 µM -0.0292778369197152 0.462303846404005 no 1540 0.48832150144993 2491 218692 SGTC_1570 verbenone 133 µM -0.030293406932086 0.462693408819899 no 1541 0.487916527333665 2470 29025 A natural terpanoid with antifungal properties. SGTC_3190 9110366 49.47 µM -0.0310783642544993 0.462994535071186 no 1542 0.487603522078735 2458 17123768 SGTC_600 1495-0418 41.6 µM -0.0312520591511996 0.463061170983256 no 1543 0.487534261484191 2471 5377768 SGTC_551 k048-0028 34.9 µM -0.0315379372207962 0.463170846846658 no 1544 0.48742026882762 2475 6836383 SGTC_1632 st005650 90 µM -0.0331580985903457 0.46379246727341 no 1545 0.486774256107288 2510 2759605 SGTC_3099 9120367 49.47 µM -0.0333185803554538 0.463854045448036 no 1546 0.48671026850213 2476 24824940 SGTC_1610 st001799 48.1 µM -0.0334612860754112 0.463908803535188 no 1547 0.486653368884015 2469 621897 SGTC_3182 9108849 49.47 µM -0.0338558174626602 0.464060194042701 no 1548 0.486496062764859 2511 17133045 SGTC_357 1325-0123 420 µM -0.0344228505735879 0.46427778642406 no 1549 0.486269981072388 2457 1098503 SGTC_1700 st030840 7.9285 µM -0.0352213687683899 0.464584226624844 no 1550 0.485951611493974 2496 5499307 SGTC_2338 7999974 200 µM -0.0354522904896238 0.464672849316874 no 1551 0.485859544555666 2522 315925 SGTC_2873 9040596 71.43 µM -0.0362163297010338 0.464966083277102 no 1552 0.485554932656285 2555 6463863 SGTC_2557 derrustone 83.84 µM -0.0363101801264974 0.465002103858847 no 1553 0.485517516363292 2526 629853 An antioxidant. SGTC_1642 st009582 77.7 µM -0.0368424013169936 0.465206380239066 no 1554 0.485305332810097 2473 6739311 SGTC_2730 imipramine 71.33 µM -0.0387584602256308 0.465941874786627 no 1555 0.484541481934233 2481 3696 A tricyclic antidepressant. SGTC_1488 4013-0813 75.9 µM -0.0398830620683345 0.466373616548146 no 1556 0.484093177434943 2476 2910057 SGTC_50 0929-0078 56.389 µM -0.0406368883144583 0.466663037397549 no 1557 0.483792687905675 2577 1377751 SGTC_859 0439-0102 54.6 µM -0.0419660526530037 0.467173393962688 no 1558 0.483262880161215 2469 610143 SGTC_1469 k284-2957 126 µM -0.0428885880199157 0.467527649797244 no 1559 0.482895172910971 2521 23884841 SGTC_32 0928-0142 34.1 µM -0.0431195196068492 0.467616332126768 no 1560 0.482803129686635 2493 2244242 SGTC_1915 st067105 30.6 µM -0.0432264579270576 0.467657399116683 no 1561 0.48276050721001 2469 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3305 9127027 53.8275 µM -0.0434716673441631 0.467751566965432 no 1562 0.482662774675988 2524 41905295 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.043727885740812 0.467849964523959 no 1563 0.482560655432273 2536 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1782 st039423 80.636 µM -0.0460865553503694 0.468755874403603 no 1564 0.481620630949401 2511 2068169 SGTC_1094 duloxetine 25.4 µM -0.0461446268616487 0.46877818037405 no 1565 0.481597488389393 2471 60834 A selective serotonin reuptake inhibitor. SGTC_366 0181-0206 4.31 µM -0.0464005964859395 0.468876502572443 no 1566 0.481495480549798 2501 274874 SGTC_3270 9137563 49.47 µM -0.0477761808374421 0.469404919807417 no 1567 0.480947309905771 2626 17015724 SGTC_2646 retinol 96.75 µM -0.048831487616904 0.469810342135784 no 1568 0.480526794304617 2546 445354 A vitamin A analog and teratogen. SGTC_2714 st079313 56.9 µM -0.0496073040402746 0.470108411284384 no 1569 0.48021766300896 2491 2939799 SGTC_148 3253-0744 288.01 µM -0.0505912829071676 0.470486480645204 no 1570 0.479825604582006 2484 6893655 SGTC_1146 3579-1023 7 µM -0.0507308712453201 0.470540116148552 no 1571 0.479769988308751 2593 X1146 SGTC_1984 st072354 53.1 µM -0.0520921030098091 0.471063184494282 no 1572 0.479227652654907 2519 5762938 SGTC_661 1304-0007 33.6 µM -0.0524874403590541 0.471215106633879 no 1573 0.479070151341186 2524 3117130 SGTC_1703 st026983 48.3 µM -0.0526382593244173 0.471273065176945 no 1574 0.479010066339649 2508 1104023 SGTC_1776 st049249 45.9 µM -0.0530789049466098 0.471442405307611 no 1575 0.478834519584508 2523 1822314 SGTC_1121 fusaric acid 630.51 nM -0.05360037152198 0.471642811602068 no 1576 0.478626780253777 2534 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1646 st011709 75.6 µM -0.0537670216325405 0.471706858893836 no 1577 0.478560392210828 2497 5757843 SGTC_2055 5235184 200 µM -0.0561372097179132 0.472617852566912 no 1578 0.4776162507969 2548 2836034 SGTC_2281 7943571 200 µM -0.0567921620214973 0.47286961223265 no 1579 0.47735537883158 2524 1244024 SGTC_1291 0993-0025 5.79 µM -0.0579045019705971 0.473297213697611 no 1580 0.476912348543748 2551 4353356 SGTC_1371 2421-0008 32.7 µM -0.0582007361185697 0.473411096103644 no 1581 0.476794367190114 2560 2827552 SGTC_1374 2889-5571 141 µM -0.0599975596140763 0.474101901939082 no 1582 0.476078789168234 2566 2853281 SGTC_1393 3470-5649 58.2 µM -0.0601537064980988 0.474161937797511 no 1583 0.476016607884278 2584 4108395 SGTC_2692 st077426 47.7 µM -0.0604087435716242 0.474259996536764 no 1584 0.475915047506964 2518 25238571 SGTC_2385 9074692 200 µM -0.0611194977365816 0.474533281319609 no 1585 0.475632020615178 2522 17046906 SGTC_196 k015-0023 18.111 µM -0.0617116780192565 0.474760983633949 no 1586 0.475396219991018 2510 5211998 SGTC_2468 5987765 72.9 µM -0.0617758244030998 0.474785649389191 no 1587 0.475370678019515 2581 26772094 SGTC_1309 pyrazolanthrone 13.4 µM -0.0642577134140548 0.475740065912954 no 1588 0.474382511819978 2544 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2051 5263410 176 µM -0.0645707656125725 0.475860460906181 no 1589 0.474257880889883 2507 227584 SGTC_262 fenpropimorph 62.5 µM -0.0655736196431916 0.476246157710385 no 1590 0.473858646185882 2521 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1743 st037606 46.3785 µM -0.0657218793257126 0.476303180154829 no 1591 0.473799626443756 2557 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3298 9116858 71.43 µM -0.0686200513879786 0.47741794775402 no 1592 0.472646028893474 2601 2506942 SGTC_405 ebelactone b 50 µM -0.0689563193850695 0.477547303190166 no 1593 0.472512194387408 2555 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_921 1561-0023 372 µM -0.0697077137002907 0.477836357777839 no 1594 0.47221315103726 2516 24050882 SGTC_2612 dictamnine 15.46 µM -0.0697386445577916 0.477848256849483 no 1595 0.47220084136746 2608 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2426 5582046 32.21 µM -0.0701337263750309 0.478000246184498 no 1596 0.472043611509041 2596 2251934 SGTC_401 neomycin 50 µM -0.0702617423300451 0.478049495050474 no 1597 0.471992666208952 2558 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2624 nerol 100 µM -0.0704908935879264 0.478137652395192 no 1598 0.47190147419273 2522 637566 A natural product oil. SGTC_609 0986-0026 86.3 µM -0.071743124415498 0.478619419982363 no 1599 0.471403168121528 2535 2848610 SGTC_1188 1403-0014 4.57 µM -0.072138001584708 0.478771346585614 no 1600 0.471246042049361 2540 9614867 SGTC_1760 st045453 10.4495 µM -0.0724865115005916 0.47890543623179 no 1601 0.47110736974692 2527 3323419 YIL048W NEO1 SGTC_939 1165-0479 45.3 µM -0.0729765336394935 0.479093976926108 no 1602 0.47091239557635 2546 1377347 SGTC_2267 7931562 200 µM -0.0742288139608916 0.47957582488487 no 1603 0.470414159431794 2512 934880 SGTC_206 4546-0025 72.014 µM -0.074344483218072 0.47962033320598 no 1604 0.470368141225805 2559 6620745 YIL048W NEO1 SGTC_616 4092-0450 108 µM -0.0751404559190019 0.479926622042682 no 1605 0.470051479810637 2591 787165 SGTC_35 0133-0054 64.071 µM -0.0751848340040206 0.479943698998979 no 1606 0.470033825455162 2567 99677 SGTC_1063 disulfiram 1.84 µM -0.0754175333726353 0.480033243729348 no 1607 0.469941254661617 2538 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_975 1335-0046 28.5 µM -0.076649273416423 0.480507244630679 no 1608 0.469451279850873 2572 16486740 SGTC_470 aa-861 153 µM -0.0768295455988129 0.480576619694913 no 1609 0.469379573104838 2553 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1405 3909-7894 12 µM -0.0777587006964003 0.480934200478782 no 1610 0.46900999950201 2612 7104060 SGTC_2746 daunorubicin 9.88 µM -0.077758777277443 0.480934229951257 no 1611 0.469009969042818 2514 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_820 1582-0060 59.9 µM -0.0782925468735592 0.481139655520503 no 1612 0.468797672999582 2578 3848840 SGTC_3119 9125183 49.47 µM -0.0783877967077247 0.481176313721852 no 1613 0.468759790238794 2521 22695334 SGTC_805 3852-0218 479 µM -0.0795962790162284 0.481641428382346 no 1614 0.468279177371607 2565 6615355 SGTC_57 miconazole 162.5 nM -0.0816097070373089 0.482416401736271 no 1615 0.467478540973364 2521 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1954 st077032 68.9 µM -0.0823265897663252 0.4826923478385 no 1616 0.467193505304537 2637 698907 SGTC_2789 5281112 71.43 µM -0.0826532572793898 0.482818093096912 no 1617 0.46706362646106 2593 765948 SGTC_1368 1852-0141 284 µM -0.082729351109774 0.482847384404763 no 1618 0.467033373026121 2626 2838987 SGTC_1896 st058441 89 µM -0.0843477164058268 0.483470374269477 no 1619 0.466389987668086 2579 688759 SGTC_705 1124-0212 310 µM -0.0861700438894409 0.484171927628094 no 1620 0.465665621811654 2547 9554485 SGTC_3206 9114350 49.47 µM -0.0865237342815049 0.484308095882982 no 1621 0.46552504479487 2567 17087243 SGTC_92 0063-0024 660.874 µM -0.0865626146198266 0.484323064645284 no 1622 0.465509591761983 2525 3594437 SGTC_1524 corynanthine 62.1 µM -0.0872064714498581 0.484570949939966 no 1623 0.465253697741694 2742 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1742 st038235 28.8875 µM -0.0875356570170699 0.484697688905317 no 1624 0.465122871998023 2659 564103 YBR002C RER2 SGTC_11 0438-0307 1.3 µM -0.0881476805969889 0.484933326771672 no 1625 0.464879650101041 2639 4011476 SGTC_1259 0671-0132 43 µM -0.0882870910903679 0.484987002552137 no 1626 0.46482424935372 2583 X1259 SGTC_2472 5377652 49.4 µM -0.0888784944368258 0.485214707479304 no 1627 0.46458923742751 2602 1610903 SGTC_1412 3909-8563 178 µM -0.0890981929083476 0.485299298061104 no 1628 0.464501936767384 2577 23767530 SGTC_2956 9076196 2.52 µM -0.0899066356761843 0.485610578738684 no 1629 0.464180704001688 2585 16423868 SGTC_2197 6588183 93.1375 µM -0.0909523306372293 0.486013223355137 no 1630 0.46376523431569 2571 884136 SGTC_2245 6637752 200 µM -0.0910670829744296 0.486057409593214 no 1631 0.463719643955292 2686 681890 SGTC_3116 9124943 49.47 µM -0.0929565002075104 0.486784967915789 no 1632 0.462969059668238 2582 41905195 YPL160W CDC60 SGTC_165 k038-0023 64.381 µM -0.0936421743806969 0.487049011630397 no 1633 0.462696703238232 2588 46368543 SGTC_2277 7947813 106.88 µM -0.0942728182959596 0.48729186896279 no 1634 0.462446220795309 2802 1246798 SGTC_1822 st052468 42 µM -0.0949657788176576 0.487558729491469 no 1635 0.462171004292336 2597 2873678 SGTC_3145 9085516 49.47 µM -0.0954603424588077 0.4877491903851 no 1636 0.461974594248561 2649 25236195 SGTC_427 1354-0053 47.3 µM -0.0962772438337213 0.488063792529292 no 1637 0.4616501919532 2824 6813657 SGTC_2818 7996756 12.99 µM -0.0978772421397871 0.48867999950999 no 1638 0.461014885672067 2568 2241621 SGTC_923 1900-2434 73.3 µM -0.0981638508627044 0.488790383958074 no 1639 0.460901093310211 2570 5910570 SGTC_1697 st025554 27.742 µM -0.0997830439177752 0.489414015653149 no 1640 0.460258284926059 2577 1269519 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.100067545332348 0.489523593999876 no 1641 0.460145350521798 2694 1609 A potent and irreversible inhibitor of serine proteases. SGTC_68 0986-0284 82.829 µM -0.10180297496896 0.490192027567294 no 1642 0.459456532118884 2829 423278 YIL048W NEO1 SGTC_2875 9039966 71.43 µM -0.102619827703994 0.490506663506157 no 1643 0.459132352843537 2687 6463691 SGTC_2779 methotrexate 400 µM -0.105001693884058 0.491424145490164 no 1644 0.458187232313276 2567 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2476 5806916 10.51 µM -0.106700449147461 0.492078524843619 no 1645 0.457513313137085 2623 2870194 SGTC_2520 obtusaquinone 4.71 µM -0.107346899944227 0.492327550550283 no 1646 0.457256889347368 2711 5967872 SGTC_3306 9127676 59.7925 µM -0.108026767736161 0.492589452372601 no 1647 0.456987229436328 2652 41905287 SGTC_1983 st071813 46.9 µM -0.109752952575018 0.493254435390194 no 1648 0.456302651977108 2664 11838595 SGTC_3218 9131285 49.47 µM -0.109922523131557 0.493319760571542 no 1649 0.456235409953442 2633 17156417 SGTC_3118 9124250 49.47 µM -0.111024440281323 0.493744266251981 no 1650 0.455798482999826 2676 1504786 SGTC_1766 st045414 44.774 µM -0.111266512691378 0.493837523877989 no 1651 0.455702504740313 2604 253960 SGTC_1911 st060208 74.3 µM -0.112132462319043 0.494171130939226 no 1652 0.45535918926128 2706 688783 SGTC_1927 st060202 13.8 µM -0.113212036430939 0.494587042507253 no 1653 0.454931226663898 2577 688887 SGTC_903 1134-0042 114 µM -0.113921414356335 0.494860337291512 no 1654 0.454650044938444 2616 701009 SGTC_2170 morpholine 200 µM -0.114186683098382 0.494962535295577 no 1655 0.454544904103783 2700 121171 Reacts with secondary amines. SGTC_974 1326-0144 138 µM -0.116360800135461 0.495800152137513 no 1656 0.453683300631525 2630 5411856 SGTC_2330 7979373 200 µM -0.116909324665828 0.496011483934541 no 1657 0.45346595440698 2650 1863007 SGTC_533 1222-0222 6.71 µM -0.118278311181955 0.496538922494015 no 1658 0.452923570962966 2795 3982874 SGTC_1130 3454-2858 15.9 µM -0.118290341354967 0.496543557467121 no 1659 0.4529188050754 2736 715628 YIL048W NEO1 SGTC_813 k007-0158 173 µM -0.118562143882441 0.496648277398007 no 1660 0.452811129273644 2687 6523916 SGTC_1271 0832-2808 169 µM -0.11906621088281 0.496842484665358 no 1661 0.452611450039759 2715 3663794 SGTC_1901 st060216 58.6 µM -0.119718866904254 0.497093941514014 no 1662 0.452352927112347 2623 688792 SGTC_2697 mebhydrolin 72.4 µM -0.119893654924448 0.497161284454132 no 1663 0.452283695428149 2691 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2340 7987427 183.45 µM -0.120263532274709 0.497303792358438 no 1664 0.452137195711875 2709 2239331 SGTC_593 1203-0218 61.7 µM -0.120648016841657 0.497451928557198 no 1665 0.451984917328689 2721 3666956 SGTC_2396 5342950 42.78 µM -0.121243562611599 0.497681384191995 no 1666 0.45174906031299 2679 1886677 SGTC_1884 5633444 25 µM -0.121834894011799 0.4979092168469 no 1667 0.451514889184709 2747 5724239 SGTC_1408 3909-7976 48.8 µM -0.122350767050331 0.498107976890398 no 1668 0.451310613840133 2646 24152374 SGTC_1266 0828-0227 32.9 µM -0.1226344895567 0.498217292164487 no 1669 0.451198270927722 2728 3913820 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.122737361513476 0.498256927672428 no 1670 0.451157538658862 2623 688662 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.123160608430061 0.498420000537294 no 1671 0.450989958973962 2750 5024745 SGTC_699 0375-0592 111 µM -0.123488132256883 0.498546192421851 no 1672 0.450860285724812 2631 762578 SGTC_2261 9010538 184.68 µM -0.124315939623966 0.498865139521705 no 1673 0.450532563602811 2746 6457250 SGTC_1916 st067606 49.2 µM -0.124557903972535 0.498958366462223 no 1674 0.450436778268572 2747 19590279 SGTC_1835 st008666 49.2 µM -0.124790460889062 0.499047968847611 no 1675 0.450344719732532 2640 690455 SGTC_295 k015-0027 31 µM -0.124922657577018 0.499098903233069 no 1676 0.450292390363663 2702 3887424 SGTC_418 lividomycin a 100 µM -0.125944217598143 0.499492503026444 no 1677 0.449888040371271 2651 72394 An antibiotic. SGTC_3214 9129694 49.47 µM -0.127198290848293 0.499975689145064 no 1678 0.449391729049938 2708 17158655 SGTC_845 0330-0138 4.51 µM -0.127324484805741 0.499975689145064 no 1679 0.449341790971639 2623 9039800 SGTC_910 3454-3003 490 µM -0.127407768646005 0.499943600424013 no 1680 0.44930883393025 2635 820824 SGTC_1521 st012942 49.4 µM -0.127423725591843 0.499937452316777 no 1681 0.449302519495197 2880 24207259 SGTC_806 3966-4455 5.86 µM -0.127598325620252 0.49987018006504 no 1682 0.449233428131462 2655 714982 SGTC_2727 riluzole 51.77 µM -0.127804610317776 0.499790699921929 no 1683 0.449151800740918 2631 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_902 1120-0002 2.07 µM -0.128141502521332 0.499660897581317 no 1684 0.449018496249725 2637 3280475 SGTC_2112 5488546 200 µM -0.128151963427023 0.49965686706396 no 1685 0.449014357077943 2627 600757 SGTC_2386 9075165 157.42 µM -0.128189714903477 0.499642321671569 no 1686 0.448999419617657 2621 16452277 SGTC_3316 9136639 10.545 µM -0.12866047703007 0.499460940206393 no 1687 0.448813155084901 2725 4903665 SGTC_125 0133-0007 11.75 µM -0.129152865798109 0.499271226262296 no 1688 0.448618345698414 2740 26541 SGTC_1050 3232-1156 69.3 µM -0.129394381681559 0.499178171941334 no 1689 0.448522796539276 2672 700529 SGTC_1024 4507-0395 26 µM -0.129550315846262 0.499118091660303 no 1690 0.448461107034332 2804 4201836 SGTC_1483 3453-0561 55.9 µM -0.130010284909161 0.498940869102032 no 1691 0.44827914478804 2729 4546991 SGTC_2597 laccaic acid a 100 µM -0.13120779186862 0.498479479907121 no 1692 0.447805466114195 2732 5491415 A textile dye. SGTC_45 0kpi-0036 14.9 µM -0.134121794528751 0.497356749319499 no 1693 0.446653132903105 2741 2795021 SGTC_2844 9010103 25.97 µM -0.134673882156595 0.497144038607103 no 1694 0.446434862026515 2819 2480525 SGTC_1249 0481-0015 10.2 µM -0.135482093685902 0.496832648849846 no 1695 0.446115360444091 2652 4227577 SGTC_3132 9126706 49.47 µM -0.135875660327606 0.496681015197748 no 1696 0.445959788623857 2866 850858 SGTC_2300 7976697 71.57 µM -0.1358823239856 0.496678447822644 no 1697 0.445957154637303 2677 2236109 SGTC_3110 9122132 49.47 µM -0.13619004104571 0.496559890701368 no 1698 0.445835523954156 2791 918317 SGTC_1458 k015-0034 6.33 µM -0.136203779901702 0.496554597406745 no 1699 0.445830093543873 2683 3598957 SGTC_1762 st045503 25.4615 µM -0.136368010272193 0.496491322918047 no 1700 0.445765180753441 2705 4645554 SGTC_522 1273-0010 11.6 µM -0.136710822798218 0.496359244787661 no 1701 0.445629687251605 2887 5705015 SGTC_3338 9144300 39.5675 µM -0.136874734327261 0.496296093418847 no 1702 0.445564904968391 2720 4901274 SGTC_2835 9006588 71.43 µM -0.137387891511663 0.496098386282337 no 1703 0.445362100732584 2881 2345538 SGTC_1698 5-fluorocytosine 1.055 µM -0.137491284284076 0.496058551645169 no 1704 0.445321240727798 2663 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2596 sinensetin 100 µM -0.137622612331157 0.496007954305338 no 1705 0.445269341761217 2699 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1534 6-azauridine 81.6 µM -0.13851165777802 0.495665429548462 no 1706 0.444918028424258 2631 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1777 st045864 34.765 µM -0.138948418217958 0.495497158919201 no 1707 0.444745454912692 2657 4691462 SGTC_1446 4239-0190 62 µM -0.139656693609579 0.495224283481399 no 1708 0.444465622237893 2672 1340085 SGTC_674 0498-0004 451 µM -0.139934982010092 0.495117068629739 no 1709 0.444355680781076 2693 4231473 SGTC_540 1187-0821 17.3 µM -0.141319176908142 0.494583791821593 no 1710 0.44380890033183 2667 847520 SGTC_2929 9013348 24.6 µM -0.141624136200975 0.494466304057681 no 1711 0.44368845058228 2752 2995952 SGTC_2473 5854593 8.94 µM -0.142036908282385 0.49430728140693 no 1712 0.443525426311379 2625 2872951 SGTC_652 0437-0092 114 µM -0.142249099974253 0.49422553377387 no 1713 0.44344162495266 2662 3091274 SGTC_1283 0922-0125 16.4 µM -0.144732643503622 0.493268758394962 no 1714 0.44246098236177 2766 3360884 SGTC_3169 9102970 49.47 µM -0.145034808543046 0.493152353033968 no 1715 0.442341694548454 2645 17027839 SGTC_1167 k781-0610 148 µM -0.14543183160357 0.492999405676297 no 1716 0.442184966916935 2721 4525169 SGTC_2116 5511452 16.8835 µM -0.145620799679471 0.49292660883452 no 1717 0.442110373623615 2781 870744 SGTC_167 3672-0051 66.205 µM -0.146771298364862 0.492483403319261 no 1718 0.441656269945764 2651 3237971 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.147997476918225 0.492011053948312 no 1719 0.441172379721558 2680 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_959 1222-0044 107 µM -0.148036135856746 0.491996161903312 no 1720 0.441157125062081 2698 6083612 SGTC_3004 9076122 71.4286 µM -0.148296507180097 0.49189586297275 no 1721 0.441054385874909 2786 44782551 SGTC_1886 st057356 49.9 µM -0.148331792312775 0.491882270650837 no 1722 0.441040463118853 2650 24207747 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.148520295229266 0.491809656876138 no 1723 0.440966085148619 2793 5377381 SGTC_475 α-linolenic acid 10 µM -0.14929478185904 0.49151131742965 no 1724 0.440660516301663 2898 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2157 5649910 96.377 µM -0.150689306683935 0.490974145593934 no 1725 0.440110404468913 2692 2858091 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.150821914415116 0.490923065849858 no 1726 0.44005809940349 2784 6708739 YPR165W RHO1 SGTC_2216 7189485 200 µM -0.15149722722724 0.490662941521261 no 1727 0.439791748973112 2756 731273 SGTC_1974 st069448 26.9 µM -0.151526384414597 0.490651710527574 no 1728 0.439780249686496 2774 6323587 YNR016C ACC1 SGTC_712 r015-0009 80.6 µM -0.151565047690985 0.490636817915526 no 1729 0.43976500137716 2786 6813872 YLR060W FRS1 SGTC_2022 5136654 200 µM -0.152844041758047 0.490144172829055 no 1730 0.439260632726037 2824 1713771 SGTC_1255 0566-0045 221 µM -0.15362554527127 0.489843159343282 no 1731 0.438952496913274 2793 2788469 SGTC_339 3091-4833 71.4 µM -0.155096084752091 0.48927676412695 no 1732 0.438372784376494 2685 3240077 SGTC_1449 4112-4002 201 µM -0.155819777214623 0.488998033509188 no 1733 0.438087540538044 2701 2059539 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.155940667569408 0.488951473031301 no 1734 0.438039894660057 2672 88881 An O-methylated flavonoid and antioxidant. SGTC_1619 st003326 88.7 µM -0.157456605183539 0.488367628194484 no 1735 0.437442502635283 2850 2849032 SGTC_2242 6630449 61.2675 µM -0.157782359017211 0.488242171299454 no 1736 0.437314149992621 2875 691249 YDR170C SEC7 SGTC_1174 0739-0097 51.1 µM -0.15799485942812 0.488160332085337 no 1737 0.437230424711148 2749 728447 SGTC_257 daunorubicin 18.5 µM -0.15839406909849 0.488006587824233 no 1738 0.437073143479927 2810 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1986 st071812 45 µM -0.158718655996043 0.487881583716334 no 1739 0.436945269571009 2695 11838594 SGTC_2095 5432005 200 µM -0.159526133053598 0.487570615328451 no 1740 0.436627185374989 2730 783734 SGTC_1320 1313-0481 95.3 µM -0.159980364585031 0.487395689027054 no 1741 0.436448270889438 2710 6813365 YLR208W SEC13 SGTC_873 0591-4978 488 µM -0.160114072811814 0.487344197937578 no 1742 0.436395607847194 2896 3305145 SGTC_1957 st077035 62.4 µM -0.161381075412659 0.486856285341125 no 1743 0.435896635467241 2701 705593 SGTC_3226 9131256 49.47 µM -0.161663055613021 0.486747699665655 no 1744 0.435785599560658 2682 17178073 SGTC_2121 5257820 149.641 µM -0.162225583818437 0.486531082771244 no 1745 0.43556410683484 2808 791256 SGTC_964 1287-0107 19.4 µM -0.163280396898611 0.486124908863415 no 1746 0.435148833887384 2820 51516812 YPR165W RHO1 SGTC_1301 naphtanilide LB 4.81 µM -0.164121255570808 0.48580113206818 no 1747 0.434817844584795 2801 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_3245 9134821 49.47 µM -0.164978630330678 0.485471005310701 no 1748 0.434480401043632 2697 17014901 SGTC_729 4092-0585 94.1 µM -0.165191543280841 0.485389026053316 no 1749 0.434396610653933 2698 2169061 SGTC_2393 9031399 185.94 µM -0.165302689073918 0.485346231111132 no 1750 0.434352871181567 2839 1526623 YDL150W RPC53 SGTC_2673 kobusone 100 µM -0.166189577439828 0.485004754761092 no 1751 0.434003880694839 2708 6710676 An epoxy ketone and protein crosslinker. SGTC_1262 0737-0114 49.6 µM -0.167208021490044 0.484612639443079 no 1752 0.433603186519809 2751 765919 SGTC_3258 9138477 49.47 µM -0.168080518503453 0.484276727611287 no 1753 0.433259967643713 2722 4970355 SGTC_2616 abietic acid 100 µM -0.168566160252719 0.484089760088543 no 1754 0.433068949905377 2766 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_442 cape 100 µM -0.168785449933549 0.484005336760247 no 1755 0.432982701695511 2794 5281787 SGTC_3301 9125354 19.7965 µM -0.169152537197528 0.483864015125097 no 1756 0.43283833077896 2691 41905162 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.169260926848904 0.483822287551656 no 1757 0.432795704172433 3103 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1004 4084-0029 199 µM -0.169510059385468 0.483726377811173 no 1758 0.432697730306215 2844 716894 YLR208W SEC13 SGTC_1462 k081-0014 26.5 µM -0.169892400338979 0.483579188024587 no 1759 0.432547378944532 2737 3270634 SGTC_668 1682-0499 62.6 µM -0.16999638440595 0.483539157667341 no 1760 0.432506490045728 2746 682214 SGTC_2164 5685496 200 µM -0.170244602373199 0.483443602796605 no 1761 0.432408888021473 2728 759046 SGTC_3350 9150499 3.57 µM -0.170523395945053 0.483336278566578 no 1762 0.432299268252487 2698 4910996 YPR165W RHO1 SGTC_3355 9151058 44.0485 µM -0.17199378415404 0.482770258837503 no 1763 0.431721207853533 2692 17015728 SGTC_2614 arthonioic acid 13.39 µM -0.173032344593466 0.482370490241746 no 1764 0.431313001879678 2691 6710684 SGTC_2148 5546263 113.568 µM -0.1733739168521 0.482239014157538 no 1765 0.431178762979683 2709 792097 SGTC_1711 st032263 62.8 µM -0.174113881619241 0.48195419769993 no 1766 0.43088798193898 2756 3958979 SGTC_1668 st014914 51.6 µM -0.175060572989368 0.481589824498943 no 1767 0.430516019001837 2715 2839556 SGTC_2756 carbadox 75.1 µM -0.17631365219482 0.481107549009564 no 1768 0.430023768573258 2757 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2598 perillyl alcohol 100 µM -0.178283357106798 0.480349520289417 no 1769 0.429250224265932 2871 10819 An apoptosis inducer. SGTC_960 1222-0186 7.7 µM -0.178379704096114 0.480312443548603 no 1770 0.429212393732246 2832 3126296 SGTC_2329 6138490 200 µM -0.178664460456185 0.48020286314769 no 1771 0.429100588279226 2997 720019 SGTC_760 0568-0725 82.9 µM -0.179395329565614 0.479921615787944 no 1772 0.428813649184298 2882 3916171 SGTC_1715 st032160 10.2275 µM -0.181201152095533 0.479226756375464 no 1773 0.428104845165079 2817 5289825 SGTC_1303 1160-0052 261 µM -0.181487993473491 0.479116388920067 no 1774 0.427992278242814 2752 3562476 SGTC_311 1315-0136 58 µM -0.181658342036317 0.479050844958735 no 1775 0.427925430083708 2879 6759207 SGTC_152 4469-0003 551.229 µM -0.181855850297249 0.478974851637907 no 1776 0.427847926509416 2730 697280 SGTC_1496 4469-0713 57.4 µM -0.18201155097772 0.478914944749322 no 1777 0.427786830473874 2826 746691 SGTC_1522 st012842 45.6 µM -0.183338245814803 0.478404509407533 no 1778 0.427266313561532 2683 3491067 YOR116C RPO31 SGTC_3346 9158254 43.5805 µM -0.183902978281588 0.478187243757965 no 1779 0.427044784164587 2829 17639500 SGTC_3189 9110682 49.47 µM -0.184183810421047 0.478079203543861 no 1780 0.426934629810577 2817 17122418 SGTC_3063 1327-0034 4 µM -0.184358357605491 0.478012053511166 no 1781 0.426866167823885 2749 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_255 tunicamycin 200.472 nM -0.184707274258322 0.477877823687858 no 1782 0.426729320160865 2831 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1874 staurosporine 7.6 µM -0.185691882993791 0.4774990538114 no 1783 0.426343197024311 2857 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1128 3448-9350 235 µM -0.185755628623746 0.477474532153842 no 1784 0.426318201033565 2844 619386 SGTC_2695 st077686 51.995 µM -0.188222809370871 0.47652552392653 no 1785 0.425350996373067 2798 2876092 SGTC_2991 9074669 71.4286 µM -0.188698467044518 0.476342575964127 no 1786 0.425164576562939 2910 17333109 SGTC_3149 9097855 49.47 µM -0.189058536274669 0.476204089066433 no 1787 0.425023469313392 2888 25236625 YMR079W SEC14 SGTC_641 4092-0595 30 µM -0.189281287309857 0.476118417813615 no 1788 0.42493618039212 2792 786260 SGTC_1114 scopoletin 1.73284 µM -0.190545350479432 0.475632273306373 no 1789 0.424440904771144 2804 5280460 A coumarin with genotoxic properties. SGTC_3180 9109287 49.47 µM -0.192396377023375 0.474920454922068 no 1790 0.423715865053559 2872 18891271 SGTC_2010 4012422 159 µM -0.19283968335963 0.474749991798526 no 1791 0.423542261956692 2834 952393 SGTC_2079 5212404 121 µM -0.193213678541776 0.474606184257935 no 1792 0.423395813325481 2826 758462 SGTC_2911 7942208 15.64 µM -0.193374372134097 0.474544395839894 no 1793 0.423332892350474 2840 1243384 SGTC_2582 agaric acid 100 µM -0.194819641973066 0.473988701706258 no 1794 0.422767072420959 2853 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2257 7960413 200 µM -0.195647269491626 0.473670508583703 no 1795 0.4224431297416 2767 2974689 YIL048W NEO1 SGTC_948 3448-0295 75.3 µM -0.196288271256183 0.47342407790822 no 1796 0.422192270503722 2753 678569 SGTC_3060 1327-0027 12.5 µM -0.196505240625652 0.473340667163525 no 1797 0.422107365603341 2846 16000455 YPR107C YTH1 SGTC_223 busulfan 5 mM -0.196883822620701 0.47319512957714 no 1798 0.421959226788446 2859 2478 A DNA alkylator. SGTC_1995 st072814 61.1 µM -0.197501307608175 0.472957758634799 no 1799 0.421717629134849 2770 5769371 SGTC_22 0964-0034 14.468 µM -0.197646599714181 0.472901907456228 no 1800 0.421660786311575 2784 138402 SGTC_2123 5259487 200 µM -0.197918139420884 0.472797527353057 no 1801 0.421554555849023 2874 2173474 SGTC_1379 2144-0755 36.5 µM -0.198397568790434 0.472613238844779 no 1802 0.421367009731876 2866 5392327 SGTC_2817 7995342 71.43 µM -0.199534201159793 0.472176350676575 no 1803 0.420922446272295 2741 18879975 SGTC_27 0485-0001 32.618 µM -0.200075831469129 0.471968175604822 no 1804 0.420710637443813 2724 2054479 SGTC_2666 tannic acid 100 µM -0.200698434993112 0.471728888022521 no 1805 0.420467191756448 2837 16134267 A thiamine antagonist. SGTC_1217 1183-1422 255 µM -0.200841010390982 0.471674092910036 no 1806 0.420411447287549 2882 2849664 SGTC_780 0109-0199 192 µM -0.202512161927432 0.471031869923001 no 1807 0.419758175770034 2951 610414 SGTC_3030 9087619 49.47 µM -0.202759349457867 0.470936882191051 no 1808 0.4196615661695 2801 25236973 SGTC_746 1095-0025 46.6 µM -0.203786257001095 0.470542286122959 no 1809 0.419260266405889 2942 6749286 SGTC_78 0336-0123 156.75 µM -0.204719356693155 0.470183761416708 no 1810 0.418895698120533 2717 6765896 SGTC_211 3455-0679 143.504 µM -0.205351675227949 0.469940819514677 no 1811 0.418648686607414 2831 748649 SGTC_2657 nystatin 74.44 µM -0.206335868015394 0.469562706969343 no 1812 0.418264281332659 2816 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_758 0868-0029 16 µM -0.207017267557978 0.469300939240763 no 1813 0.417998186520921 2898 762687 SGTC_301 4119-0100 24.5 µM -0.207636357720012 0.469063119902205 no 1814 0.417756456819042 2791 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1111 tnp00062 510.699 nM -0.208883458931655 0.468584087924231 no 1815 0.417269608596448 2925 676306 SGTC_2196 6573537 42.6665 µM -0.209834717978942 0.468218724300852 no 1816 0.416898337602875 2865 2903087 SGTC_2344 7990960 76.95 µM -0.210732214327835 0.467874034619387 no 1817 0.416548117816344 2820 140813 SGTC_1683 st010134 710 nM -0.211045947138882 0.467753549030943 no 1818 0.416425709040677 2765 3818134 SGTC_1575 cyproterone acetate 48 µM -0.212249669519239 0.467291300376846 no 1819 0.41595612934508 2828 9880 An androgen receptor antagonist and liver toxin. SGTC_2337 9009472 200 µM -0.213232311291477 0.46691398288479 no 1820 0.415572883493007 2961 5742383 SGTC_2060 5238662 140 µM -0.214986070158177 0.466240643828285 no 1821 0.414889089522872 2885 790130 SGTC_2679 rapamycin 1 nM -0.215696234707134 0.465968010271556 no 1822 0.414612268203102 2869 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1463 k081-0032 34.1 µM -0.216707569858501 0.465579784329202 no 1823 0.414218124148302 2861 977755 SGTC_1939 st074455 53.6 µM -0.217432329587708 0.465301587557726 no 1824 0.413935719220175 3022 1644229 SGTC_34 0469-0683 81.75 µM -0.217472176482338 0.46528629294151 no 1825 0.413920194040496 2884 3690923 SGTC_1553 gossypol 38.6 µM -0.218957313095897 0.46471628291486 no 1826 0.413341650050909 2755 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3019 9081971 49.47 µM -0.220810543805628 0.464005096431207 no 1827 0.412619976721464 2947 16451803 SGTC_3014 9081533 49.47 µM -0.221687907068636 0.463668443893546 no 1828 0.412278422328146 2935 21367265 SGTC_1096 rimcazole 32.2 µM -0.221842970725275 0.463608947208012 no 1829 0.412218063499264 2780 18528119 A dopamine reuptake inhibitor. SGTC_1868 st057644 42.7 µM -0.221942771556037 0.463570654857424 no 1830 0.412179216930577 2780 688665 SGTC_2723 salbutamol 83.58 µM -0.222124542340021 0.463500912511912 no 1831 0.412108466511649 2889 9884233 β2-adrenoceptor agonist SGTC_3161 9100388 49.47 µM -0.224677497981208 0.462521506521553 no 1832 0.411115085544887 2819 25236368 SGTC_2661 dactinomycin 12.96 µM -0.224679419650229 0.462520769384732 no 1833 0.411114338017734 2837 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1047 2043-3044 82 µM -0.225242107070841 0.462304932551468 no 1834 0.410895467118992 2812 669592 SGTC_566 0958-0068 16.5 µM -0.225544022247015 0.46218912785967 no 1835 0.410778041330034 2970 6815365 SGTC_453 enantio-paf c16 10 µM -0.226181905692204 0.461944467385588 no 1836 0.410529971571674 2912 13871343 A lipid and platelet activating factor SGTC_252 miconazole 1.30953 nM -0.226238604297592 0.461922721306196 no 1837 0.410507923491282 2894 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3345 9148410 3.559 µM -0.226357888225554 0.461876971738393 no 1838 0.410461539118054 2943 4903596 SGTC_342 k048-0088 23.3 µM -0.226694941444138 0.461747702742168 no 1839 0.410330480434294 2766 6820570 SGTC_438 sphingosine 6.67 µM -0.226776283826491 0.461716506350329 no 1840 0.410298853024715 2793 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1367 1812-0510 76.9 µM -0.227584959891542 0.461406376131866 no 1841 0.409984456707648 2854 1142582 YDR527W RBA50 SGTC_3065 9113888 49.47 µM -0.228367933439206 0.461106125281229 no 1842 0.409680108116899 3005 16648368 SGTC_878 0828-0289 13.7 µM -0.228824397177681 0.46093109302746 no 1843 0.409502701810503 2832 745350 YLR208W SEC13 SGTC_2686 alizarin 95.37 µM -0.229226901363811 0.460776757988127 no 1844 0.40934628245396 2878 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2958 9077254 16.72 µM -0.230715873250981 0.460205882453185 no 1845 0.408767770556786 2999 16457351 SGTC_2778 tioconazole 65.09 nM -0.23156283668514 0.459881191081151 no 1846 0.408438787496644 2775 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2796 7949634 45.45 µM -0.232073491809639 0.45968543956605 no 1847 0.40824046666422 2784 2971588 SGTC_525 k781-2675 26.7 µM -0.233940639691614 0.458969781684558 no 1848 0.407515531275538 2817 3651118 YDL195W SEC31 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.233941979809591 0.458969268079092 no 1849 0.407515011077214 2989 23847180 SGTC_2808 7946468 45.46 µM -0.234041518951055 0.458931119504582 no 1850 0.407476373073459 2900 2970879 SGTC_1153 4055-0057 267 µM -0.23410523456343 0.458906700567554 no 1851 0.407451641123742 2822 882706 SGTC_382 3229-0966 23.2 µM -0.234200294986796 0.45887026905511 no 1852 0.407414743009962 2993 5722370 SGTC_3312 9133330 71.43 µM -0.237952306817816 0.457432605106235 no 1853 0.405959042714742 2981 17617324 SGTC_769 0302-0231 76 µM -0.238149954215614 0.457356887534235 no 1854 0.405882395603356 2915 571869 YER009W NTF2 SGTC_3074 9116018 49.47 µM -0.23892488860669 0.457060029620034 no 1855 0.405581913029564 2797 17027303 SGTC_1561 5-methoxyflavone 52.9 µM -0.239759949746208 0.456740165482134 no 1856 0.405258178448525 2810 94525 SGTC_615 k087-0205 167 µM -0.240556852686597 0.456434943698992 no 1857 0.404949297382502 2850 9642773 SGTC_386 1509-0011 3.07 µM -0.241579746309546 0.45604320292227 no 1858 0.40455290870514 2815 3107280 SGTC_1299 1079-1439 3.74 µM -0.241704184748361 0.455995549250793 no 1859 0.404504693367791 2851 323161 SGTC_2964 9083345 53.42 µM -0.245328398304165 0.454607937982855 no 1860 0.403101082405967 2888 17741579 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.245814073650927 0.454422028012363 no 1861 0.402913081039453 2839 97141 SGTC_2815 7968870 71.43 µM -0.246966440231796 0.453980957654622 no 1862 0.402467098260678 2834 2977326 YHR190W ERG9 SGTC_1276 0871-0068 94.2 µM -0.247325083906114 0.45384369770421 no 1863 0.40232832376356 2937 3414906 SGTC_1280 0880-0253 10.1 µM -0.249923114735155 0.45284954610256 no 1864 0.401323403683333 2864 6836607 SGTC_2941 9056145 11.23 µM -0.251173161970092 0.452371313162625 no 1865 0.400840116606776 2833 2119517 SGTC_1376 2910-0861 41.3 µM -0.251394631662841 0.452286592267413 no 1866 0.400754508890775 2834 1112859 SGTC_1653 st012112 65 µM -0.25139842730416 0.452285140303782 no 1867 0.400753041751041 3014 720429 SGTC_306 1672-3436 11.6 µM -0.251412312100505 0.452279828896041 no 1868 0.400747674834245 2936 6797378 SGTC_1030 k029-0042 36.7 µM -0.254151609869138 0.451232122402193 no 1869 0.399689216536886 2913 6080581 SGTC_1914 st062367 72.6 µM -0.255072066941544 0.450880148615632 no 1870 0.399333719041406 2862 978205 SGTC_1699 st031318 29.054 µM -0.255959360627828 0.450540892739193 no 1871 0.398991108852874 2960 5340658 SGTC_3281 9140613 49.47 µM -0.2561871728525 0.450453794776798 no 1872 0.398903156394791 2889 16013766 SGTC_656 4090-1979 187 µM -0.256821900908279 0.450211135936393 no 1873 0.398658131256404 2983 22330961 SGTC_953 1188-0045 9.7 µM -0.258994341122929 0.449380745571237 no 1874 0.397819803349138 2978 6144426 SGTC_2939 9044578 71.43 µM -0.259045408535012 0.449361228290534 no 1875 0.397800102487271 2833 2653634 SGTC_3047 9092122 49.47 µM -0.25923347628775 0.449289352371908 no 1876 0.397727551678654 2922 17173831 SGTC_852 0418-0143 439 µM -0.260535438469902 0.448791812943829 no 1877 0.397225391468894 2968 5369229 SGTC_3090 9117696 49.47 µM -0.261281701419904 0.448506667917407 no 1878 0.396937638368479 2938 7923821 SGTC_3271 9137798 49.47 µM -0.261562189976233 0.448399500879112 no 1879 0.396829498694015 2993 6498326 SGTC_268 camptothecin 39.6153 µM -0.262069580270072 0.448205650438332 no 1880 0.396633899390717 2904 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_349 k015-0014 24 µM -0.262290091103859 0.448121407266856 no 1881 0.396548900419058 2826 2196908 SGTC_1921 5740136 50 µM -0.262863100648307 0.447902507695131 no 1882 0.396328048905078 3075 1774243 SGTC_3028 9087778 49.47 µM -0.264294258615983 0.447355849997086 no 1883 0.39577659200219 2868 17217395 SGTC_133 0724-0033 378.92 µM -0.264753626795191 0.447180406831338 no 1884 0.395599631417508 2810 280309 SGTC_1857 st056007 79.3 µM -0.266843244317858 0.44638246527221 no 1885 0.394794928455329 2949 619834 SGTC_1770 st043884 66.3 µM -0.267057373899031 0.446300709935509 no 1886 0.394712493333448 2856 670149 SGTC_2341 7987486 176.74 µM -0.268878208878055 0.445605602086429 no 1887 0.394011703225251 3041 1258686 SGTC_862 0452-0056 10.2 µM -0.269668929281023 0.445303794729514 no 1888 0.393707483035518 2938 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2640 pentamidine 10.38 µM -0.270857298331589 0.444850269896003 no 1889 0.393250394347745 2996 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1895 st058434 18.3 µM -0.271951700830396 0.44443266994664 no 1890 0.392829578614548 3057 5393175 SGTC_1387 3342-1166 1.8 µM -0.272591955028383 0.444188391576819 no 1891 0.392583448391293 2956 3418228 SGTC_3272 9137413 49.47 µM -0.273281426915206 0.443925358724115 no 1892 0.392318445654635 2854 17614870 SGTC_2737 bleomycin 30.5 nM -0.274202029473239 0.443574188272315 no 1893 0.391964684289055 2911 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2007 4011539 71.82 µM -0.275145800634102 0.443214225986233 no 1894 0.391602112579173 2875 45595301 SGTC_2677 mitomycin C 100 µM -0.275291962986086 0.443158482614589 no 1895 0.39154596931272 2922 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2448 5185112 27.17 µM -0.275603222431947 0.443039778292863 no 1896 0.391426417175569 3026 5718189 SGTC_578 3460-0051 92 µM -0.276940837718381 0.442529713251505 no 1897 0.390912767251851 2968 2876744 SGTC_1279 0874-0590 65.2 µM -0.277358775403671 0.442370362999372 no 1898 0.390752316380919 2955 3523074 SGTC_926 2268-1401 59.4 µM -0.27934998034764 0.441611289746843 no 1899 0.389988126748371 2870 2931578 SGTC_546 peri-Naphthalide 147 µM -0.28070958820904 0.441093112528129 no 1900 0.389466577004662 2965 223824 A penicillin ester. SGTC_2968 9090663 33.37 µM -0.280855829419485 0.441037382694991 no 1901 0.389410490266624 2975 25236811 SGTC_2717 st081029 62.2815 µM -0.281533831486094 0.440779023860869 no 1902 0.389150491595783 3014 5292846 SGTC_882 0843-0131 351 µM -0.282039869133677 0.440586210048024 no 1903 0.388956469778817 2892 5425421 SGTC_1615 st002656 86.5 µM -0.282125439016835 0.440553607036025 no 1904 0.388923663840554 2878 1584458 SGTC_604 1000-0114 314 µM -0.282828471558534 0.440285759630328 no 1905 0.388654163942194 3053 1572745 SGTC_1101 ebselen 5.29 µM -0.282993415944286 0.440222921647316 no 1906 0.388590942057011 3071 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2359 9039622 200 µM -0.283522298009109 0.440021446428411 no 1907 0.388388245631998 2879 6463596 SGTC_2990 9074105 71.4286 µM -0.283654184080729 0.43997120744606 no 1908 0.388337704435446 2962 6502001 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.284415491246365 0.439681223812126 no 1909 0.388045994347162 2928 689007 SGTC_392 N-ethylmaleimide 8.33 µM -0.285252773971711 0.439362338284632 no 1910 0.387725245632556 2943 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2262 9014885 67.46 µM -0.285572291552048 0.439240657932019 no 1911 0.387602864085081 2903 6457424 SGTC_928 2764-0428 58.7 µM -0.287109065143267 0.438655496200405 no 1912 0.387014405640681 3024 662578 SGTC_1572 epiandrosterone 68.9 µM -0.288113519218511 0.438273099682762 no 1913 0.386629922183137 2883 441302 A steroid. SGTC_340 k038-0059 454 µM -0.289137643751363 0.437883273935054 no 1914 0.386238023840595 2916 23733424 SGTC_1137 ixabepilone 100 µM -0.290185110038745 0.437484625667939 no 1915 0.385837313415032 2888 154225 A novel microtubule stabilizer. SGTC_3034 9090421 49.47 µM -0.290815083799228 0.437244898651587 no 1916 0.385596374251779 2916 17173761 SGTC_1267 0828-0272 9.49 µM -0.291347502907588 0.437042312546562 no 1917 0.385392780158434 3059 745334 SGTC_2837 9008476 45.46 µM -0.291540859438266 0.4369687442396 no 1918 0.385318849514918 3111 2992805 SGTC_773 4358-1457 44.6 µM -0.292143382531014 0.436739510199011 no 1919 0.385088499136538 3096 1186886 SGTC_2016 5121758 140 µM -0.292333287086654 0.436667264107922 no 1920 0.385015905196306 2852 2795203 SGTC_383 2324-0395 7.37 µM -0.293173072993273 0.436347806613269 no 1921 0.384694932450981 3049 3146421 SGTC_1540 guanosine 70.6 µM -0.293335957607673 0.436285849537056 no 1922 0.384632685819357 2894 6802 Guanosine is a purine nucleoside SGTC_83 0170-0301 39.027 µM -0.295238784507801 0.435562179806724 no 1923 0.383905737998151 2901 3089716 SGTC_2438 5259590 200 µM -0.295846552497169 0.435331083104379 no 1924 0.383673634837456 3019 1201127 SGTC_965 1291-5240 308 µM -0.296733122670139 0.434994014743748 no 1925 0.383335133554421 3060 2834598 SGTC_534 k292-0788 63.4 µM -0.296768617753516 0.434980520719827 no 1926 0.383321583031782 3094 4146317 SGTC_1289 0976-0073 69.1 µM -0.296863125616079 0.434944592412889 no 1927 0.383285504620235 3033 3391136 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.296874033835399 0.434940445555961 no 1928 0.383281340468619 3042 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1450 4112-4260 37.6 µM -0.297565129836862 0.43467773385142 no 1929 0.383017545951967 3082 1633175 SGTC_3201 9113999 49.47 µM -0.300203482119415 0.433675062640496 no 1930 0.382010974579229 3123 16649224 SGTC_1713 st033146 12.748 µM -0.300728096084943 0.433475740627503 no 1931 0.381810921185508 3082 674619 SGTC_986 1493-0483 84 µM -0.301904395238168 0.433028878687807 no 1932 0.38136247254881 3048 40079 SGTC_3039 9090270 49.47 µM -0.303587819260166 0.432389515174532 no 1933 0.38072096633947 3066 17173750 SGTC_943 3253-1379 105 µM -0.303932852837246 0.432258493415002 no 1934 0.380589524032041 3131 668464 SGTC_2897 9048598 12.99 µM -0.303966102892522 0.432245867556731 no 1935 0.380576857981178 2951 6467404 SGTC_417 st075190 100 µM -0.304262906559686 0.432133167020532 no 1936 0.380463801275346 3078 222757 SGTC_1332 1480-0653 17.5 µM -0.306287642089351 0.431364494197526 no 1937 0.379692823780388 3084 5749438 SGTC_2132 5317594 122.667 µM -0.30632309225151 0.431351038165255 no 1938 0.379679329339628 2936 794577 SGTC_1789 tunicamycin 25 nM -0.306577391256707 0.43125451469169 no 1939 0.379582532305997 3064 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1669 st015249 58.4 µM -0.307165569875299 0.431031277321798 no 1940 0.379358675390907 3045 722793 SGTC_537 1334-0398 209 µM -0.307277421560419 0.430988827613531 no 1941 0.379316109949209 3109 5846986 SGTC_1625 st003711 30.1 µM -0.307491086229826 0.430907740279349 no 1942 0.379234803385643 3151 24207034 YER133W GLC7 SGTC_2130 NSC 7 2.4545 µM -0.308660306666697 0.4304640640762 no 1943 0.378789970528219 3065 21448 SGTC_263 alizarin 107.927 µM -0.309452955046931 0.430163333017884 no 1944 0.378488496713799 2994 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2347 9049783 174.81 µM -0.3097123891006 0.430064912442033 no 1945 0.378389840295596 3119 6467988 YPL169C MEX67 SGTC_2854 9024559 71.43 µM -0.309714873818214 0.430063969844531 no 1946 0.37838889545664 3041 3163529 SGTC_350 k064-0020 19.8 µM -0.310155891748266 0.429896672483787 no 1947 0.378221205459273 3153 2790705 SGTC_994 3910-0338 138 µM -0.310701839365707 0.429689588147671 no 1948 0.378013649404291 3139 3479481 SGTC_172 1112-0046 2.638 µM -0.312032762371683 0.429184834606858 no 1949 0.377507812359228 2974 2802135 YIL048W NEO1 SGTC_1796 st049173 110.4 µM -0.312151322929491 0.429139876030781 no 1950 0.377462761835425 3059 94134 SGTC_2221 6807166 181.081 µM -0.312764592973409 0.428907336583746 no 1951 0.377229758718169 3024 674925 SGTC_3073 9114972 49.47 µM -0.313389544536382 0.428670393127803 no 1952 0.376992363349338 3073 41905075 SGTC_266 formosanin C 406 nM -0.315641900099484 0.427816651367015 no 1953 0.376137165306615 3069 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1345 1488-0192 31.4 µM -0.315782273378409 0.427763454866584 no 1954 0.376083886983236 3111 658348 SGTC_2374 9071832 200 µM -0.316122849752137 0.427634393944232 no 1955 0.375954631898741 2927 17381698 SGTC_1667 st014849 34.6 µM -0.317811304797653 0.426994670965348 no 1956 0.37531403748841 2939 5348460 SGTC_105 0111-0055 734.78 µM -0.318412488606432 0.42676694029567 no 1957 0.375086033165283 3049 5179370 SGTC_1044 1222-0021 1.78 µM -0.319558319099625 0.426332963087459 no 1958 0.374651587646581 3065 4306703 SGTC_1514 1189-1591 158 µM -0.319725439744563 0.426269674471602 no 1959 0.374588236565199 3159 767698 YMR146C TIF34 SGTC_2161 5662504 8.5105 µM -0.320024252179643 0.426156518886632 no 1960 0.37447497299594 2997 2859334 SGTC_2053 5265679 138 µM -0.320655027715242 0.425917674051665 no 1961 0.374235915813434 2948 764595 SGTC_648 0375-0473 33.3 µM -0.322456386722842 0.425235734578042 no 1962 0.373553486485841 2971 1713139 SGTC_2918 7977171 22.06 µM -0.322527328473993 0.425208882762592 no 1963 0.37352661891266 2943 2236483 SGTC_1712 st032288 53.4 µM -0.323155278626586 0.42497121556114 no 1964 0.373288823905778 3066 2883011 SGTC_2785 7756463 72.73 µM -0.323433046945427 0.424866094223768 no 1965 0.373183652728046 2960 2201551 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.324331254432974 0.424526204476724 no 1966 0.372843629915961 3045 688664 SGTC_2747 doxorubicin 7.63 µM -0.32673151092454 0.423618201952567 no 1967 0.371935482431039 3009 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_17 0960-0276 49.807 µM -0.326771389182828 0.423603119659149 no 1968 0.37192040031789 2996 6821114 SGTC_2834 9001755 58.44 µM -0.328493387198842 0.422951952550287 no 1969 0.371269321700827 3013 2989575 SGTC_54 0159-0055 9 µM -0.328579051600993 0.422919564357317 no 1970 0.371236942029275 3218 3319099 SGTC_2518 prenyletin 46.28 µM -0.328721837163907 0.422865580823333 no 1971 0.371182973566488 3082 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2669 eugenol 100 µM -0.328798202810134 0.422836709539009 no 1972 0.371154110787824 3048 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1705 st027868 56.3335 µM -0.329088071945804 0.42272712353445 no 1973 0.371044559892945 3053 292948 SGTC_1574 spiramycin 23.7 µM -0.330452263015501 0.422211466929088 no 1974 0.370529128541858 2940 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3196 9111891 49.47 µM -0.331096850742776 0.421967862690216 no 1975 0.370285665177322 2968 18891510 SGTC_331 k048-0133 24.5 µM -0.332103061228015 0.421587652761902 no 1976 0.369905719334955 2976 6813582 SGTC_812 4251-0442 148 µM -0.332804443157073 0.421322669540856 no 1977 0.369640952049212 3134 5723007 SGTC_2047 4141938 200 µM -0.333229233567883 0.421162200356947 no 1978 0.36948062636879 3017 3807862 SGTC_2188 6126565 140.678 µM -0.333936352361688 0.420895107620292 no 1979 0.369213793798173 3095 874518 SGTC_3184 9108758 49.47 µM -0.334750850772609 0.420587500607329 no 1980 0.368906519417258 2934 902885 SGTC_1843 st055809 45.5 µM -0.337879819851543 0.419406253042637 no 1981 0.367726877791737 3150 16413835 SGTC_324 1315-0088 19.6 µM -0.338160362241146 0.419300378060944 no 1982 0.367621172230168 3071 6787421 SGTC_209 4077-0173 175.592 µM -0.339654563325099 0.41873657432492 no 1983 0.367058341345091 3075 15993494 SGTC_2787 5284540 71.43 µM -0.341161934199428 0.418167970345012 no 1984 0.36649083906643 3050 736958 SGTC_2430 5571206 200 µM -0.342812862737308 0.417545410378968 no 1985 0.365869624316654 3165 1731771 SGTC_362 0310-0100 9.03 µM -0.343220816050327 0.417391604242624 no 1986 0.365716172913725 3135 790235 SGTC_1682 st012968 530 nM -0.343448435879918 0.417305792741529 no 1987 0.365630563182827 3007 24207270 SGTC_737 1950-0117 57.9 µM -0.343568958162422 0.417260358057565 no 1988 0.365585236449112 3149 5393513 SGTC_949 1165-0505 146 µM -0.344550917800948 0.416890218555827 no 1989 0.365216005245041 3009 6244267 SGTC_274 sirtinol 40.1 µM -0.345233520758671 0.416632961829124 no 1990 0.36495941010871 3047 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1947 st076332 61.6 µM -0.345465087773143 0.416545697864901 no 1991 0.364872376208108 3122 24208416 SGTC_1295 1013-0063 9.78 µM -0.345934741763467 0.416368725580759 no 1992 0.364695879279256 3136 6826038 SGTC_2019 4016004 108 µM -0.346465375096721 0.416168795813669 no 1993 0.364496500689627 3087 45595336 SGTC_3084 9116877 49.47 µM -0.346655225718989 0.416097269970648 no 1994 0.364425175681652 3086 27241325 SGTC_588 3970-1144 52.9 µM -0.347982260512812 0.415597389983963 no 1995 0.363926752986971 3128 1888707 SGTC_1395 3486-0190 4.35 µM -0.348496059608022 0.415403883919914 no 1996 0.363733836280217 3191 6748079 SGTC_3299 9121982 43.1275 µM -0.349561972267611 0.415002507347369 no 1997 0.363333727097456 3035 17594604 YPL160W CDC60 SGTC_43 0570-0105 72.5 µM -0.349763064183497 0.4149267947688 no 1998 0.363258260388088 3014 1114046 YDL195W SEC31 SGTC_660 4031-1742 102 µM -0.350110837149819 0.414795863159903 no 1999 0.363127759060618 3027 6738706 SGTC_2237 6667747 47.222 µM -0.350263543449243 0.414738374384932 no 2000 0.363070461250979 2985 729940 YDL015C TSC13 SGTC_3199 9111318 49.47 µM -0.351714345804527 0.4141922874478 no 2001 0.362526250380601 3134 8548020 SGTC_871 0574-0004 149 µM -0.352313719992859 0.413966729318018 no 2002 0.362301499946362 3006 9551173 SGTC_2762 leflunomide 42.06 µM -0.352590643275465 0.413862526372747 no 2003 0.362197676616474 3014 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_425 3825-7017 13.1 µM -0.354001527121537 0.413331721834834 no 2004 0.361668869386704 3251 3397440 SGTC_1555 citronellol 128 µM -0.354111745819137 0.413290261871207 no 2005 0.361627569904294 3114 8842 A terpine precursor. SGTC_2513 baicalein 25.65 µM -0.354705955104907 0.413066760245176 no 2006 0.361404944573488 3073 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2182 6325192 200 µM -0.354869690671279 0.413005178869782 no 2007 0.361343607957287 3094 736248 SGTC_2046 4110841 106 µM -0.355254886749824 0.412860314059794 no 2008 0.36119932456804 3197 44119630 YMR134W ERG29 SGTC_9 0092-0002 10.449 µM -0.359192975301733 0.411379959130053 no 2009 0.359725365681258 3104 759368 SGTC_2859 9028643 45.46 µM -0.360170673308446 0.411012630184389 no 2010 0.359359752182717 3100 17151580 SGTC_1020 4335-0961 93.3 µM -0.360912540812051 0.410733956680424 no 2011 0.359082414181788 2994 669075 SGTC_2275 7947463 200 µM -0.361262907422975 0.410602361379399 no 2012 0.358951459757541 3180 1225414 SGTC_193 1273-0060 1.558 µM -0.362064987070012 0.410301143663909 no 2013 0.358651733689323 3098 2847393 YHR072W ERG7 SGTC_976 1348-1067 47.6 µM -0.362853495375652 0.41000507418249 no 2014 0.358357163875642 3036 5310671 YGL099W LSG1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.363171547345859 0.409885666383476 no 2015 0.358238370313403 3229 688751 SGTC_1641 st009299 47.1 µM -0.364188014073901 0.409504105414964 no 2016 0.357858808358081 3126 4046054 SGTC_1612 st002233 45.4 µM -0.364452985198117 0.409404654703568 no 2017 0.357759887748415 3128 1035021 SGTC_2000 st075254 36.4 µM -0.364530218815204 0.409375667969606 no 2018 0.357731056228812 3045 17234175 SGTC_632 0781-2353 4.65 µM -0.364700199675049 0.409311873791025 no 2019 0.357667604770222 3129 6811515 YHR007C ERG11 SGTC_1702 st027038 51 µM -0.365292968058931 0.409089425355052 no 2020 0.357446363474883 3100 5521182 SGTC_3224 9130643 49.47 µM -0.365961856483425 0.40883844647788 no 2021 0.357196769121137 3229 17644395 SGTC_473 2-arachidonoylglycerol 10 µM -0.366701821379279 0.408560841986579 no 2022 0.356920723903042 2992 5282280 An endocannabinoid. SGTC_2308 7584454 197.62 µM -0.367880381404057 0.408118789356781 no 2023 0.356481214683421 3236 893577 SGTC_1477 0139-0234 16 µM -0.368438913032532 0.407909336900913 no 2024 0.356272993282594 3095 620880 SGTC_1758 st042942 75.2445 µM -0.369771112826552 0.407409860940914 no 2025 0.355776520341347 3116 669317 SGTC_3172 9105863 49.47 µM -0.370178135129855 0.407257287790259 no 2026 0.355624883443536 3099 2348785 SGTC_2622 2-methoxyxanthone 59.94 µM -0.370590491973881 0.407102729324009 no 2027 0.355471282449608 3091 71034 A hepatoprotective. SGTC_2784 7567673 72.73 µM -0.371921653109799 0.406603885974524 no 2028 0.354975591452786 3108 3471247 SGTC_826 1683-5028 118 µM -0.372963080910689 0.406213723768743 no 2029 0.354587960898801 3138 722377 SGTC_1859 st055998 20 µM -0.375139025720817 0.405398825208132 no 2030 0.353778537252568 3260 676301 SGTC_2027 5150920 200 µM -0.376148503908866 0.40502091124841 no 2031 0.353403248347775 3104 786715 SGTC_2712 st079126 47.7 µM -0.376781769178977 0.404783883661183 no 2032 0.353167895032245 3050 3152970 SGTC_3297 9117502 71.43 µM -0.376849679666485 0.404758467224537 no 2033 0.353142659401878 3159 7453720 SGTC_2907 7721985 69.9 µM -0.378256944847072 0.404231869410598 no 2034 0.352619863231796 3137 3267881 SGTC_1076 itraconazole 331 nM -0.37858339673871 0.404109736055941 no 2035 0.352498626736774 3122 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2497 7-hydroxyflavone 100 µM -0.378729585970147 0.404055046244495 no 2036 0.352444340377497 3216 5281894 SGTC_222 nsc-310342 10.666 µM -0.381568409155703 0.402993407362159 no 2037 0.351390760108156 3175 432556 SGTC_1507 4075-3230 155 µM -0.385333100017029 0.401586623909337 no 2038 0.349995320535023 3147 659771 SGTC_1454 4239-0054 42.6 µM -0.385832712327544 0.401400025004644 no 2039 0.349810283353172 3262 1340767 SGTC_626 0214-0009 33 µM -0.385897913396866 0.401375674884205 no 2040 0.349786138015214 3220 3437874 SGTC_3259 9138485 49.47 µM -0.385913226330372 0.401369956141276 no 2041 0.349780467399457 3384 17646153 SGTC_549 1661-1316 519 µM -0.385913319224081 0.401369921449408 no 2042 0.349780432999585 3224 2857282 SGTC_75 0159-0059 199.013 µM -0.38705250037327 0.400944544071584 no 2043 0.349358670695819 3364 5377270 SGTC_2589 lobaric acid 100 µM -0.387846900633464 0.40064797949227 no 2044 0.349064667614046 3088 73157 A novel microtubule depolymerizer. SGTC_161 4065-0411 162.148 µM -0.388933235388397 0.400242522985719 no 2045 0.348662767855222 3191 1906281 YLR208W SEC13 SGTC_630 4356-0227 183 µM -0.389049615754248 0.400199092303444 no 2046 0.348619721905447 3153 779312 SGTC_2383 9036125 200 µM -0.389082333800572 0.400186882845256 no 2047 0.34860762073594 3075 79580 SGTC_1364 1653-0028 37.6 µM -0.389401083687407 0.400067939424837 no 2048 0.348489735255234 3138 5718652 SGTC_2089 5281248 129.67 µM -0.389567621400615 0.400005798570528 no 2049 0.348428149276609 3104 2737878 SGTC_1647 st011722 22.4 µM -0.389726257105867 0.399946608577248 no 2050 0.348369489191829 3218 2854783 SGTC_1286 0929-0070 131 µM -0.390616892012541 0.399614338502862 no 2051 0.348040218858027 3190 1420408 SGTC_775 4577-0580 57.3 µM -0.391078904801564 0.39944200353764 no 2052 0.347869456479308 3295 2006902 SGTC_153 4077-0274 519.67 µM -0.3917522099437 0.399190889695111 no 2053 0.347620654575136 3379 3121976 SGTC_102 gallobenzophenone 83.616 µM -0.392527172706912 0.398901913570205 no 2054 0.347334369048527 3270 70837 SGTC_1204 4049-0315 18.3 µM -0.393057230431947 0.398704292065638 no 2055 0.347138606093169 3301 588402 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.393727351721359 0.398454487814043 no 2056 0.346891172699669 3197 17037758 SGTC_2719 novobiocin 32.65 µM -0.395166568787748 0.397918124877313 no 2057 0.346359981658632 3219 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_558 k064-0027 21.3 µM -0.395285600627744 0.397873773083561 no 2058 0.346316062499235 3180 5088526 SGTC_913 3487-1245 167 µM -0.395922179641524 0.397636603323791 no 2059 0.346081219129113 3044 4016153 SGTC_88 0180-0332 8.668 µM -0.396679072621533 0.397354657519282 no 2060 0.345802067188625 3085 3101745 SGTC_3154 9100113 49.47 µM -0.396766717653324 0.397322012839398 no 2061 0.345769747976172 3104 25237525 SGTC_390 dec-rvkr-cmk 16.7 µM -0.396947255031508 0.397254771307066 no 2062 0.345703178139673 3153 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1650 st011916 45.8 µM -0.397094262661791 0.397200020256513 no 2063 0.345648975304493 3247 242528 SGTC_1257 0669-0121 16 µM -0.397848691197783 0.396919075206571 no 2064 0.345370861550778 3169 4307855 SGTC_137 0438-0332 85.389 µM -0.399181989343412 0.396422693173782 no 2065 0.34487955654568 3207 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_25 0118-0223 35.662 µM -0.400569845577105 0.39590617764916 no 2066 0.344368425205812 3248 5333628 SGTC_883 0850-0245 24.6 µM -0.400792811200814 0.395823214015837 no 2067 0.344286336018413 3294 6823229 YPR165W RHO1 SGTC_2638 epoxomicin 18 µM -0.401078899926106 0.395716769720431 no 2068 0.344181017562376 3219 9915668 A protesome inhibitor. SGTC_1764 st044502 93.5 µM -0.401890726933223 0.395414757709347 no 2069 0.343882223766942 3230 8407 SGTC_3174 9107204 49.47 µM -0.401907896678949 0.395408370979956 no 2070 0.343875905475665 3232 3938802 SGTC_1003 4049-0218 100 µM -0.40411880699214 0.394586201199308 no 2071 0.343062677867306 3268 295161 SGTC_2369 9071472 200 µM -0.404339885306964 0.394504014701243 no 2072 0.342981399671411 3238 17296037 SGTC_2705 st078069 42.8 µM -0.406029600546785 0.39387601356307 no 2073 0.342360425601314 3186 1530061 SGTC_2431 5490079 200 µM -0.406166785266047 0.393825039449153 no 2074 0.342310028587255 3171 5722345 SGTC_1558 st069300 45.6 µM -0.406533614289472 0.393688744690055 no 2075 0.342175281838306 3223 24208000 SGTC_2593 nobiletin 86.24 µM -0.40835249079605 0.3930131366082 no 2076 0.341507453797348 3173 72344 An anti-infammatory. SGTC_2533 agelasine 13.65 µM -0.40852872887067 0.39294769137924 no 2077 0.3414427716407 3320 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1307 1187-1599 12.2 µM -0.408707836297524 0.392881183729205 no 2078 0.34137704115766 3093 1538471 SGTC_901 1112-0062 60.1 µM -0.409342101338063 0.392645688348955 no 2079 0.34114431146742 3130 1908457 SGTC_3003 9075612 71.4286 µM -0.40946735035892 0.392599189458639 no 2080 0.341098361218135 3188 6501993 SGTC_1021 4476-0760 85.3 µM -0.40987660179586 0.392447264928907 no 2081 0.340948235115614 3121 746768 SGTC_111 0083-0039 52.457 µM -0.410262691574286 0.392303953618791 no 2082 0.340806628509562 3060 759313 SGTC_3059 1327-0034 3 µM -0.410514880942537 0.392210352216436 no 2083 0.340714144824314 3117 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_709 3807-1509 243 µM -0.411927680074937 0.391686099908399 no 2084 0.340196215837033 3185 1886677 YPL242C IQG1 SGTC_3230 9131665 49.47 µM -0.413554875605224 0.391082534483304 no 2085 0.339600063059436 3127 15943720 SGTC_2366 9070441 60.58 µM -0.413935108468673 0.39094153483724 no 2086 0.339460815567673 3136 6837235 SGTC_108 0509-0257 621.132 µM -0.41431472672944 0.390800777401103 no 2087 0.339321815015026 3163 536624 SGTC_293 4049-0273 38.5 µM -0.416899125994881 0.389842897415874 no 2088 0.338376096430531 3155 1380311 SGTC_3205 9113483 49.47 µM -0.418166988239509 0.389373221916939 no 2089 0.337912515037973 3283 17018033 SGTC_1733 st037357 54.9 µM -0.420371717759024 0.38855687204398 no 2090 0.337106962827368 3043 1272339 YGL099W LSG1 SGTC_502 l-744,832 89.3 µM -0.420445791438331 0.388529453147999 no 2091 0.337079911124111 3244 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1148 3909-7663 27.7 µM -0.420777084760055 0.388406829382057 no 2092 0.336958933134693 3263 4084526 SGTC_1780 st038448 24.544 µM -0.420818170301745 0.388391622896456 no 2093 0.336943931151264 3303 728868 YDL195W SEC31 SGTC_2973 9094665 17.96 µM -0.423440452778725 0.387421424622611 no 2094 0.335986967847707 3335 25237061 YIL048W NEO1 SGTC_2703 st077852 53.4 µM -0.426379709602804 0.386334786813234 no 2095 0.334915592010423 3250 6281836 SGTC_3022 9087993 49.47 µM -0.426590062776188 0.386257053693796 no 2096 0.334838968444209 3234 17173644 SGTC_2683 piperine 63.03 µM -0.42659397905467 0.386255606530274 no 2097 0.334837541959851 3161 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_663 1486-0733 13.9 µM -0.427063716462728 0.386082038211609 no 2098 0.334666459808406 3146 722445 YPR165W RHO1 SGTC_224 benfluorex 43.875 µM -0.427335739145248 0.385981536051467 no 2099 0.334567402642686 3266 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_997 3996-0078 137 µM -0.427932588597836 0.38576104942622 no 2100 0.334350100037956 3191 735687 SGTC_10 0279-0212 42.575 µM -0.427979802130982 0.38574360949562 no 2101 0.334332912771543 3186 39851 YBR002C RER2 SGTC_2358 9037157 4 µM -0.428497777859889 0.385552292646852 no 2102 0.334144375519146 3230 2388925 SGTC_1903 st060211 78.3 µM -0.43029690073555 0.384887994464512 no 2103 0.333489840654465 3296 688960 SGTC_521 r062-0005 13.8 µM -0.431783536098381 0.384339332198107 no 2104 0.332949373289126 3166 2832033 SGTC_191 3914-0123 66.505 µM -0.432429178398724 0.384101121527305 no 2105 0.332714757523418 3116 3144412 SGTC_2602 kawain 100 µM -0.432593406597617 0.384040536273189 no 2106 0.332655090149283 3233 5369129 SGTC_101 0490-5701 117.494 µM -0.433101886660659 0.383852971396576 no 2107 0.332470376104979 3235 4661669 SGTC_1013 4112-3890 241 µM -0.433660033492067 0.383647117082326 no 2108 0.332267666589814 3099 705171 SGTC_1614 st002383 48.6 µM -0.434920007824375 0.383182537314418 no 2109 0.33181024561797 3241 1947235 SGTC_1072 oxiconazole 14.9 nM -0.434944635802918 0.383173458117885 no 2110 0.331801307173831 3244 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3322 9139058 2.11 µM -0.436780251985178 0.382496932296703 no 2111 0.33113536102055 3328 4908926 YPR165W RHO1 SGTC_1523 st012844 44.7 µM -0.439685289670446 0.381426998910104 no 2112 0.330082529137955 3307 4274103 SGTC_2119 5528445 120.635 µM -0.440349578596495 0.381182466378009 no 2113 0.329841968794785 3310 791935 SGTC_1018 4259-0013 28.1 µM -0.440919707427112 0.380972633100599 no 2114 0.329635562947002 3275 6801262 SGTC_294 k038-0071 157 µM -0.441533555423994 0.380746748313475 no 2115 0.329413387289407 3234 24152826 SGTC_303 1348-1668 34.2 µM -0.442066779256442 0.380550564721073 no 2116 0.329220441542042 3209 5380509 SGTC_2564 betulinic acid 100 µM -0.442647027901657 0.380337114668721 no 2117 0.329010531650495 3414 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2415 st077333 57.7 µM -0.443465312993339 0.380036162546472 no 2118 0.328714601674721 3398 2766255 SGTC_2606 farnesol 9.78 µM -0.443917897674134 0.3798697403464 no 2119 0.328550972093009 3324 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_916 4466-0038 42 nM -0.444046353628346 0.379822509209972 no 2120 0.328504535514477 3382 5722064 YGL116W CDC20 SGTC_1337 1486-1011 40.3 µM -0.44415066926971 0.379784155387525 no 2121 0.328466827561052 3280 X1337 SGTC_1738 st035555 74 µM -0.444398280331114 0.379693120749156 no 2122 0.328377328263688 3267 5331140 SGTC_1773 st048542 73.5835 µM -0.44543442067554 0.379312254326559 no 2123 0.328002921042162 3167 3237138 SGTC_484 loperamide 105 µM -0.445666001851033 0.379227145279672 no 2124 0.327919263261987 3198 3955 An opioid-receptor agonist. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.446945916152295 0.378756866066528 no 2125 0.327457055121507 3227 6708630 An antioxidant. SGTC_1159 4092-0538 61.2 µM -0.448286661284819 0.378264428221425 no 2126 0.326973162975342 3218 717301 SGTC_954 1189-0853 2.85 µM -0.448720176052298 0.378105246267813 no 2127 0.326816764095868 3262 2828194 SGTC_2531 methyl deoxycholate 70.07 µM -0.44885741236592 0.378054858881881 no 2128 0.326767259766285 3141 16667744 Haematoxylin. SGTC_1287 0971-0001 34.6 µM -0.449527821050971 0.377808742920385 no 2129 0.326525471610731 3251 4665869 SGTC_1143 3454-2408 5.08 µM -0.44996889454365 0.377646846005051 no 2130 0.326366434722099 3270 X1143 SGTC_410 α-linolenic acid 100 µM -0.450774083267342 0.377351355308827 no 2131 0.326076191027716 3314 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2948 9070189 9.45 µM -0.451028969217662 0.377257831410502 no 2132 0.32598433508012 3284 6473636 YDL196W YDL196W SGTC_1082 camptothecin 424.86 nM -0.451470092011512 0.377095989665422 no 2133 0.325825387943685 2988 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2023 5144124 124 µM -0.451727144097366 0.377001690826046 no 2134 0.325732780498337 3171 2830192 SGTC_292 k038-0015 474 µM -0.451963521229729 0.376914983009877 no 2135 0.325647631051508 3305 46368540 SGTC_781 4335-2806 94.4 µM -0.455875139349835 0.375481028294783 no 2136 0.324239883830245 3324 845254 SGTC_2642 cholecalciferol 100 µM -0.456142895373987 0.375382934605713 no 2137 0.324143612981436 3277 9821465 A vitamin D precursor, similar to steriods. SGTC_2306 7482397 179.52 µM -0.45630298916311 0.375324287335346 no 2138 0.324086057371778 3336 891448 SGTC_2740 felodipine 17.08 µM -0.456948080434585 0.375087999807757 no 2139 0.323854182048743 3259 3333 L-type calcium channel blocker SGTC_2699 st077704 54.6 µM -0.45869033944451 0.374450070195854 no 2140 0.323228276183946 3265 645852 SGTC_2210 7115885 190.385 µM -0.459226537214022 0.374253809977794 no 2141 0.323035747894851 3243 2927039 SGTC_2345 9052315 157.45 µM -0.459658046535625 0.374095891700903 no 2142 0.32288084367895 3288 6469265 SGTC_982 1491-0518 27.5 µM -0.462126819898993 0.373192808448247 no 2143 0.321995189071044 3209 3091256 SGTC_985 1493-0307 8.71 µM -0.463013247365522 0.372868720744491 no 2144 0.321677435793403 3360 3278274 SGTC_2840 9008771 71.43 µM -0.464570499198707 0.372299590177049 no 2145 0.321119531272664 3262 2992978 SGTC_1929 genistein trimethyl ether 50.5 µM -0.465079995789581 0.37211344435797 no 2146 0.320937085432185 3383 136420 SGTC_3285 9112818 20.8695 µM -0.466680693772884 0.371528820055475 no 2147 0.320364172251533 3247 17017947 YPR165W RHO1 SGTC_2326 6164455 177.58 µM -0.467427637791284 0.371256114328179 no 2148 0.320096976406329 3262 2888790 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.467986102605189 0.371052263680106 no 2149 0.319897264029844 3200 4000243 SGTC_3051 9093778 49.47 µM -0.468972032750075 0.37069246811819 no 2150 0.319544813376522 3276 17217378 SGTC_2307 7538926 6.34 µM -0.469165879587148 0.37062174086637 no 2151 0.319475536098748 3254 96582 SGTC_464 bw-b 70c 158 µM -0.470145003004373 0.370264563268135 no 2152 0.31912571180238 3334 5353454 SGTC_2926 9010726 65.15 µM -0.470720717980738 0.370054598531326 no 2153 0.318920093690305 3331 2994293 SGTC_574 1315-0397 40 µM -0.471128809237121 0.369905790045838 no 2154 0.318774376569738 3261 6794277 SGTC_3057 9095946 49.47 µM -0.47160368478226 0.369732653515024 no 2155 0.318604848053587 3269 24540043 SGTC_1085 doxorubicin 7.67 µM -0.471648324044761 0.369716379687888 no 2156 0.318588913981428 3343 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_86 0417-1630 471.922 µM -0.472010669312505 0.369584290617288 no 2157 0.318459586544243 3319 3634867 SGTC_761 k216-0224 480 µM -0.472906837114825 0.36925766841308 no 2158 0.31813982342194 3396 1340404 SGTC_367 0335-0881 7.1 µM -0.473391999814511 0.369080882723941 no 2159 0.317966768230197 3359 23828853 SGTC_455 paf C-16 10 µM -0.474113696847776 0.368817958866994 no 2160 0.317709415921107 3238 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2155 5570423 76 µM -0.47652243270631 0.367940869219218 no 2161 0.316851114798085 3229 797402 SGTC_1933 st074711 15.9 µM -0.476745525370029 0.367859669543127 no 2162 0.316771670294663 3304 17250958 SGTC_1841 st054148 70 µM -0.477369414502809 0.367632622185274 no 2163 0.316549544865131 3289 675442 SGTC_204 PMA1.184 62.41 µM -0.477613788861943 0.367543701434964 no 2164 0.316462557432274 3274 2252213 YGL008C PMA1 SGTC_2483 5729050 27.16 µM -0.478166416049071 0.367342642602181 no 2165 0.316265881847835 3399 2865180 SGTC_512 prima-1 270 µM -0.478984347061995 0.367045126722001 no 2166 0.315974882145532 3377 322968 A re-activator of the apoptotic function of mutant p53. SGTC_220 paclitaxel 373.376 µM -0.479012186424759 0.36703500177967 no 2167 0.315964979591143 3318 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_320 4092-0846 5.34 µM -0.479557570592861 0.366836668800163 no 2168 0.315771011260466 3295 1359356 SGTC_1036 k216-0215 33.5 µM -0.480096757982064 0.366640624262434 no 2169 0.315579296705096 3293 622330 SGTC_2070 5230947 200 µM -0.482200558141341 0.365876031199611 no 2170 0.314831740197757 3365 2835538 SGTC_1902 st060212 70.5 µM -0.482241583077722 0.365861126614774 no 2171 0.314817170076063 3372 688944 SGTC_2824 7998404 51.95 µM -0.483014270426468 0.365580442894125 no 2172 0.314542801850831 3214 837851 SGTC_3121 9125696 49.47 µM -0.483070238762841 0.365560114823963 no 2173 0.314522932414948 3290 1235365 SGTC_2074 5212007 75.395 µM -0.485134539027022 0.364810611537299 no 2174 0.313790456571415 3342 758611 SGTC_2061 5245884 80.95 µM -0.486988546220067 0.36413790116379 no 2175 0.313133223917293 3250 573863 SGTC_2860 9025725 38.96 µM -0.490885696948978 0.362725220133933 no 2176 0.311753646911527 3213 40546248 SGTC_100 0086-0128 49.5915 µM -0.491633703928213 0.362454287447283 no 2177 0.311489156311788 3299 93297 SGTC_132 0417-1715 25.805 µM -0.492124533483412 0.362276543405015 no 2178 0.311315654879447 3427 6769098 SGTC_2794 7785382 27.27 µM -0.495095224157554 0.361201402438681 no 2179 0.310266452424915 3368 2205081 SGTC_887 0885-0007 9.62 µM -0.495180379510096 0.361170599451296 no 2180 0.310236399559527 3363 5719458 SGTC_1501 4491-0275 38.4 µM -0.495428483719894 0.361080858600571 no 2181 0.310148846317942 3355 5104718 SGTC_2033 5192550 145 µM -0.496845743997953 0.360568373373369 no 2182 0.309648917216565 3278 182073 SGTC_1870 st057514 26.5 µM -0.497085770769069 0.360481603794995 no 2183 0.309564284200913 3246 5393161 SGTC_1573 oleylamine 1.06 µM -0.497814027712248 0.360218383193323 no 2184 0.309307563897446 3327 5356789 An amine of the fatty acid oleic acid. SGTC_1677 st019204 53.9 µM -0.497961284978855 0.360165166694079 no 2185 0.309255665050295 3318 3945625 SGTC_524 r073-0010 27.8 µM -0.498658904450199 0.359913094643279 no 2186 0.30900985016339 3242 2772106 SGTC_1855 st056195 39.6 µM -0.499346105224495 0.359664846750719 no 2187 0.308767790025367 3395 4028379 SGTC_1235 benzylparaben 21.5 µM -0.500606367740972 0.359209737032231 no 2188 0.308324090040938 3350 7180 SGTC_328 k915-0120 63.5 µM -0.502280212935657 0.35860558195702 no 2189 0.307735212964469 3354 6624543 SGTC_744 1594-0068 283 µM -0.505877541120203 0.357308366389847 no 2190 0.306471309769631 3305 668392 SGTC_2585 alliin 100 µM -0.506349533528949 0.357138285360706 no 2191 0.306305647879327 3462 87310 A garlic compound which reacts with lipids. SGTC_2371 9071574 200 µM -0.510184625610293 0.355757376529268 no 2192 0.304961061090693 3375 45596039 SGTC_561 1550-0330 72.9 µM -0.511182103329925 0.355398521941581 no 2193 0.304611774591831 3298 6812934 SGTC_2213 7173844 200 µM -0.512082312950239 0.355074770734951 no 2194 0.304296701285164 3307 892728 SGTC_2273 7815444 169.05 µM -0.512409611064861 0.354957087223102 no 2195 0.304182182952383 3396 2824616 SGTC_2377 9073351 62.6 µM -0.512491316439128 0.354927711346138 no 2196 0.304153598055198 3277 7337946 YHR072W ERG7 SGTC_3064 1327-0027 10 µM -0.51267215352892 0.354862697293368 no 2197 0.304090335853713 3318 16000455 YPR107C YTH1 SGTC_2403 6032726 181.2 µM -0.512953036940636 0.354761723243401 no 2198 0.303992086098059 3322 2881040 SGTC_1270 0831-1170 17.3 µM -0.514384751176673 0.354247198680643 no 2199 0.303491509160005 3401 6764716 SGTC_1314 1222-0010 41.1 µM -0.514652402866525 0.354151040410554 no 2200 0.303397969711914 3331 3526027 SGTC_1147 3809-1045 12.3 µM -0.514958272457169 0.354041163117397 no 2201 0.303291089570506 3325 325925 SGTC_693 4161-2696 114 µM -0.515320556085646 0.353911035975974 no 2202 0.303164518425165 3370 805759 SGTC_1797 st048695 56.8 µM -0.516939551810076 0.353329724369272 no 2203 0.302599178276415 3382 592262 YIL048W NEO1 SGTC_3236 9132701 49.47 µM -0.517743398531028 0.353041224620781 no 2204 0.302318657174568 3365 24282524 SGTC_2354 9060492 162 µM -0.519150576263937 0.352536393414547 no 2205 0.301827870708746 3410 6471895 SGTC_2858 9025781 8.96 µM -0.522872894421183 0.351202249112051 no 2206 0.300531354190241 3428 4894980 YPL153C RAD53 SGTC_1629 st005085 44.9 µM -0.523739709811693 0.350891829564422 no 2207 0.300229796082568 3293 24207091 SGTC_2653 dihydrofissinolide 100 µM -0.524354350187 0.350671777933921 no 2208 0.300016050561885 3405 6857746 SGTC_716 1683-5115 658 µM -0.525113957873471 0.350399894770355 no 2209 0.299751986803992 3436 723597 SGTC_557 1315-0110 16.2 µM -0.531048367293215 0.348278464317245 no 2210 0.297692631310633 3366 6833801 SGTC_2984 9022109 38.96 µM -0.531062975359639 0.348273248050631 no 2211 0.297687570000979 3465 6459207 SGTC_1323 1348-1351 11.2 µM -0.533043983738734 0.347566133314919 no 2212 0.297001566882614 3339 6989654 SGTC_79 0052-0007 94.094 µM -0.533069329943422 0.347557089495782 no 2213 0.296992794435767 3467 2801472 SGTC_1203 3992-3522 103 µM -0.533194519212261 0.347512421788679 no 2214 0.296949467548962 3587 5322312 SGTC_3187 9109394 49.47 µM -0.534233791697121 0.347141689701577 no 2215 0.296589896335334 3345 17098090 SGTC_3147 9097027 49.47 µM -0.535179696055886 0.346804391249222 no 2216 0.296262802446184 3337 25236841 SGTC_2399 5884133 200 µM -0.535214247915166 0.346792072755806 no 2217 0.296250857539957 3338 722445 SGTC_1479 0549-0158 134 µM -0.537103534594983 0.346118747597997 no 2218 0.2955980497079 3402 5440202 SGTC_1231 0242-0792 125 µM -0.537147568911157 0.346103059944782 no 2219 0.295582842359163 3361 3707635 SGTC_3317 9138495 8.753 µM -0.54087222253212 0.344777074244273 no 2220 0.294297829040906 3435 17020139 SGTC_1097 itavastatin 7.23 µM -0.541334903185151 0.344612491467539 no 2221 0.294138383566671 3416 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_202 3594-0513 34.79 µM -0.542151882740895 0.344321950831786 no 2222 0.293856939827652 3392 708429 SGTC_1794 st048918 76.9 µM -0.542380238118741 0.344240757729686 no 2223 0.29377829527902 3393 672303 SGTC_2586 curcumin 80 µM -0.543567762335215 0.343818642296398 no 2224 0.293369474457272 3415 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_406 estrone 100 µM -0.54564788962153 0.343079712890078 no 2225 0.292653999309667 3471 5870 A steroid. SGTC_701 4424-0219 185 µM -0.545765382043129 0.343037993596669 no 2226 0.292613611118893 3487 2911779 SGTC_347 4534-1311 26.2 µM -0.548135201608495 0.342196925479965 no 2227 0.291799535637729 3417 2862016 SGTC_1779 st039427 55 µM -0.549737453229771 0.341628716351078 no 2228 0.291249732089964 3501 1124498 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.550119184492147 0.341493395224823 no 2229 0.29111881453888 3525 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1282 0886-0010 32.4 µM -0.550152578445403 0.341481558265226 no 2230 0.291107363143772 3505 2836211 YNL267W PIK1 SGTC_2867 9039098 71.43 µM -0.550285947046852 0.341434285430848 no 2231 0.291061630717988 3410 6463460 SGTC_346 4513-0042 7.16 µM -0.550291069405086 0.341432469847762 no 2232 0.291059874315509 3417 2827372 SGTC_3017 9080681 49.47 µM -0.55101973698304 0.341174236265532 no 2233 0.290810072367599 3421 16451914 SGTC_1403 3909-7815 62.9 µM -0.551378636713501 0.341047072585738 no 2234 0.29068707115198 3366 6615483 SGTC_2967 9089538 49.85 µM -0.55165455965879 0.34094932112799 no 2235 0.290592524079822 3487 728216 SGTC_2980 9014342 25.29 µM -0.55248213644177 0.340656198848085 no 2236 0.290309034998508 3487 2996599 SGTC_474 dl-dihydrosphingosine 5 µM -0.553723862491181 0.340216568111463 no 2237 0.289883920889689 3491 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3235 9132602 49.47 µM -0.553778035083137 0.340197393347111 no 2238 0.28986538115023 3490 4912240 SGTC_2097 5376186 200 µM -0.555941727802076 0.339431877643417 no 2239 0.289125345603728 3444 742755 SGTC_1854 st056233 32.9 µM -0.556238598440948 0.339326896228201 no 2240 0.289023877975483 3422 5393174 SGTC_2805 7950783 58.44 µM -0.556331736366851 0.339293962730529 no 2241 0.288992047749482 3438 1178958 YDL195W SEC31 SGTC_1033 k072-0102 21.3 µM -0.557898684413806 0.338740075358554 no 2242 0.288456784969009 3471 5965931 SGTC_12 0849-0099 9.267 µM -0.55842987398281 0.338552388640618 no 2243 0.288275438981697 3415 6071388 SGTC_1771 st048882 4.1505 µM -0.561946422839603 0.33731088960284 no 2244 0.287076261604546 3328 4580403 SGTC_2036 5160441 105 µM -0.562092695672945 0.33725928698685 no 2245 0.28702643235893 3417 134534 YIL048W NEO1 SGTC_1194 1488-0194 225 µM -0.563500100425072 0.336762934621475 no 2246 0.286547195863187 3412 1391452 SGTC_264 promethazine 12.5 mM -0.56432630372141 0.336471688108303 no 2247 0.286266041666251 3531 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1967 st070177 51.4 µM -0.566502347080764 0.335705076621568 no 2248 0.285526168934832 3506 5729214 SGTC_1959 st077091 55.8 µM -0.567758485809939 0.335262854725549 no 2249 0.285099486185338 3427 821356 YKL052C ASK1 SGTC_2244 6635614 200 µM -0.568272145008614 0.335082087417687 no 2250 0.284925095034771 3273 836499 SGTC_2247 cerulenin 830 nM -0.568309272315271 0.335069023029266 no 2251 0.284912492007693 3548 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_477 mead ethanolamide 10 µM -0.568725349166428 0.33492262720252 no 2252 0.284771271087066 3368 16061185 SGTC_570 0987-0065 62.6 µM -0.570056107328287 0.334454571022383 no 2253 0.284319821991418 3367 3104428 SGTC_1210 3013-0140 750 nM -0.571151879501627 0.334069357497961 no 2254 0.28394834699806 3493 905973 SGTC_925 2064-1272 59.6 µM -0.571189310109468 0.334056202029038 no 2255 0.283935661844435 3389 6815817 SGTC_96 0929-0093 37.281 µM -0.573645757484092 0.333193298404189 no 2256 0.283103770522408 3396 6991579 SGTC_2248 tofa 1.1 µM -0.573729443724322 0.333163916521872 no 2257 0.283075450266498 3410 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3163 9099914 49.47 µM -0.574840644183768 0.332773875901089 no 2258 0.282699537925199 3489 16268368 SGTC_1643 st009866 20.2 µM -0.577274340342548 0.331920260735529 no 2259 0.281877072357808 3473 3156273 YOR207C RET1 SGTC_1834 st055981 52.8 µM -0.577457514518573 0.331856047896571 no 2260 0.281815215483313 3533 471719 YDL150W RPC53 SGTC_1968 st069590 43.6 µM -0.578975485872787 0.331324103869079 no 2261 0.281302857109332 3453 6384066 SGTC_2523 spermine 47.74 µM -0.579737118808954 0.331057332250454 no 2262 0.281045953920502 3455 1103 A DNA binding polyamine. SGTC_2227 7312221 64.1025 µM -0.579819702212853 0.331028411513537 no 2263 0.281018104874721 3484 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1306 1185-0270 9.02 µM -0.58053176648266 0.330779088195542 no 2264 0.280778035561835 3494 1548076 SGTC_2087 5276107 200 µM -0.580644215700511 0.33073972190635 no 2265 0.280740132875786 3474 144405 SGTC_61 0978-8327 98.565 µM -0.582095282535869 0.330231899634238 no 2266 0.280251251277663 3502 6150059 YHR072W ERG7 SGTC_2324 6149169 200 µM -0.582823683316558 0.329977102785946 no 2267 0.280005999990402 3392 2888231 SGTC_860 0443-0016 25.1 µM -0.583603227916449 0.329704503024203 no 2268 0.279743643983716 3488 5337942 SGTC_3109 9122853 49.47 µM -0.584829503973653 0.329275868350191 no 2269 0.279331181891224 3476 1234709 SGTC_186 3455-3465 67.277 µM -0.585979639425549 0.328874051806337 no 2270 0.278944598666908 3464 755278 SGTC_754 3474-0146 171 µM -0.586952389983222 0.328534361543351 no 2271 0.278617841288685 3360 24762078 SGTC_2091 4-phenylthiadiazole 200 µM -0.58804377698659 0.328153411361114 no 2272 0.278251454680761 3439 270010 SGTC_3349 9149703 23.001 µM -0.589183118913437 0.327755913047707 no 2273 0.277869220043598 3498 4910494 SGTC_1988 st071872 53.4 µM -0.590500764856397 0.327296450582415 no 2274 0.277427486566 3531 16414116 SGTC_784 4579-0127 173 µM -0.590502700558093 0.327295775796451 no 2275 0.277426837885375 3548 1948547 SGTC_2012 4023501 200 µM -0.591436849816938 0.32697019708661 no 2276 0.277113877994848 3420 3477460 SGTC_3325 9138760 55.175 µM -0.591483358722436 0.326953990793017 no 2277 0.277098301037183 3416 43844959 SGTC_414 piperonyl butoxide 100 µM -0.591559734808043 0.326927377818087 no 2278 0.277072721767944 3412 5794 A potent inhibitor of cytochrome P450. SGTC_3238 9133470 49.47 µM -0.592193208486493 0.326706680110183 no 2279 0.276860608370223 3537 3534688 SGTC_1949 st076024 69.1 µM -0.594703794605558 0.325832606674835 no 2280 0.276020742456055 3452 2921930 SGTC_904 1141-0088 396 µM -0.595333495295264 0.325613522992449 no 2281 0.275810285221129 3484 1378119 SGTC_1108 betulinic acid 729.144 nM -0.59653007910569 0.325197376940462 no 2282 0.275410582916321 3482 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2207 7258803 200 µM -0.597122440043671 0.324991447185147 no 2283 0.275212818440431 3497 3666799 SGTC_2293 7624732 200 µM -0.597600111899968 0.324825427142417 no 2284 0.275053394775592 3480 894453 SGTC_596 1155-0152 116 µM -0.599352864186103 0.32421653727279 no 2285 0.274468801179856 3521 280313 SGTC_1118 chelidonine 707.474 nM -0.60015950116647 0.323936476834709 no 2286 0.274199970580592 3536 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1740 st038286 13.222 µM -0.602271193907681 0.323203779528914 no 2287 0.273496816141845 3543 716786 SGTC_829 1635-0120 117 µM -0.607488289025624 0.321396538551135 no 2288 0.271763456087082 3527 285054 SGTC_1119 parthenolide 318.541 nM -0.609544402145019 0.320685442374062 no 2289 0.271081825446321 3586 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1401 3807-4679 7.6 µM -0.609933359372512 0.320550997390073 no 2290 0.270952976585746 3524 3291456 SGTC_1504 k297-0033 30 µM -0.612965427317603 0.319503756324223 no 2291 0.269949599974295 3392 4388117 SGTC_2813 7971799 71.43 µM -0.613085582563964 0.319462285663394 no 2292 0.269909876354895 3538 2234054 SGTC_1404 3909-7820 48.3 µM -0.613408596504855 0.319350811076855 no 2293 0.269803101660923 3543 23741373 SGTC_155 k072-0202 43.6 µM -0.614246632412338 0.319061674610282 no 2294 0.269526181225826 3508 5857737 SGTC_2898 9056270 58.44 µM -0.617116819244603 0.318072246677666 no 2295 0.268578837808174 3484 19154699 SGTC_1230 0170-0365 3.77 µM -0.617385703366093 0.317979621676285 no 2296 0.268490174830257 3621 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1923 st058458 19.1 µM -0.619931438977486 0.317103233419598 no 2297 0.267651463137602 3606 3534982 SGTC_1225 1216-0074 20.6 µM -0.620113684271517 0.317040533386747 no 2298 0.267591471749125 3505 4241466 SGTC_2506 ethyl hematommate 54.16 µM -0.62025234041239 0.316992833371096 no 2299 0.267545833551027 3512 3940691 An allergen. SGTC_1298 1079-1278 263 µM -0.620352499456037 0.316958378888184 no 2300 0.267512868983296 3556 2840950 SGTC_2065 5221596 34.26 µM -0.62109188413134 0.316704081364482 no 2301 0.267269584431445 3548 788581 SGTC_1717 st033143 58.0435 µM -0.622226654625815 0.316313966752595 no 2302 0.266896420800528 3594 674616 SGTC_319 1348-1596 45.5 µM -0.625321253160366 0.315251136351454 no 2303 0.265880116885109 3605 5380505 SGTC_1 0258-0098 57.368 µM -0.6269625421719 0.314688059850534 no 2304 0.265341894540198 3480 6790032 YDR047W HEM12 SGTC_2828 7998861 71.43 µM -0.62855729243164 0.314141361819744 no 2305 0.264819463720962 3495 2988188 SGTC_2913 7966556 36.57 µM -0.629021655690714 0.313982249518706 no 2306 0.264667439403419 3519 2976516 SGTC_2715 st079500 56.4 µM -0.62967756538218 0.313757563479282 no 2307 0.264452781824171 3538 28246688 SGTC_3123 9126162 49.47 µM -0.629894254452345 0.313683350430251 no 2308 0.264381886123732 3591 25239884 SGTC_396 dithiazanine 1.25 µM -0.631698310266298 0.313065778834374 no 2309 0.263792016197035 3510 10578 An antihelmenthic. SGTC_601 0986-0029 62.9 µM -0.631907051370879 0.31299435554019 no 2310 0.263723807716714 3574 24747981 SGTC_2291 7917025 104.35 µM -0.632137913096992 0.312915371580105 no 2311 0.263648381554072 3528 2964612 SGTC_3088 9117578 49.47 µM -0.63245560240649 0.312806695624096 no 2312 0.263544605447157 3623 678341 SGTC_1578 josamycin 24.2 µM -0.634465571941858 0.312119497573176 no 2313 0.262888514083795 3499 5282165 A P450 substrate. SGTC_748 act1.228 77.9 µM -0.636309875193611 0.311489514523539 no 2314 0.262287234847267 3546 4421505 YNR035C ARC35 SGTC_1620 st003704 16.5 µM -0.636401074091158 0.311458376805788 no 2315 0.262257520496194 3566 2834414 SGTC_3192 9110362 49.47 µM -0.636453007363415 0.311440646014517 no 2316 0.262240600410034 3630 16649480 SGTC_3021 9087658 49.47 µM -0.637162319351099 0.311198520148192 no 2317 0.262009559470308 3579 25237042 SGTC_886 0866-0150 153 µM -0.640181374667113 0.310168870778306 no 2318 0.261027345055033 3628 271463 SGTC_1169 aniline yellow 25.8 µM -0.641121530268119 0.309848533684603 no 2319 0.260721863409152 3539 6051 A DNA damaging agent. SGTC_459 nigericin 15.3 µM -0.642303726370888 0.309445931532343 no 2320 0.26033799762323 3640 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_996 3970-0799 1.8 µM -0.643784745193252 0.308941886574635 no 2321 0.25985751359305 3646 6615648 YGL040C HEM2 SGTC_1917 st066507 28.5 µM -0.644747801250518 0.308614316176167 no 2322 0.259545316858057 3530 3156428 SGTC_759 3486-0358 89.3 µM -0.645060683504135 0.308507926293449 no 2323 0.259443930590177 3624 875103 SGTC_435 c-PAF 6.7 µM -0.645103586546407 0.308493339152451 no 2324 0.259430029896759 3533 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2297 7971671 152.32 µM -0.647408331787812 0.307710164814644 no 2325 0.258683852491558 3620 909016 SGTC_1086 cerivastatin 2.18 µM -0.647546194384191 0.307663345508229 no 2326 0.258639253753054 3567 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_420 mitomycin C 81.9 mM -0.647838923407458 0.307563942637694 no 2327 0.258544568715899 3579 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3077 9117319 49.47 µM -0.649775347263891 0.306906741518146 no 2328 0.257918672727314 3599 17154678 SGTC_1898 st060199 18.6 µM -0.650228512735175 0.306753031557357 no 2329 0.257772312990065 3603 688866 SGTC_1434 4073-0095 163 µM -0.650567875507566 0.306637944772441 no 2330 0.257662736568592 3599 24133745 SGTC_1045 1348-1485 165 µM -0.652340304847874 0.306037177640097 no 2331 0.257090832326273 3639 6810614 SGTC_2145 5634607 200 µM -0.655337588903719 0.305022431275128 no 2332 0.256125212298192 3577 308662 SGTC_3186 9110464 49.47 µM -0.655740266662445 0.304886216522273 no 2333 0.255995627891755 3615 17018021 SGTC_1987 st072290 61.9 µM -0.656022544782636 0.304790745755992 no 2334 0.255904809294298 3595 54697379 SGTC_2876 9059903 25.97 µM -0.658892789814396 0.303820740638874 no 2335 0.254982308108075 3592 6916095 SGTC_3332 9141069 11.198 µM -0.658936251437527 0.30380606328485 no 2336 0.254968352860387 3584 17332883 SGTC_1928 4'-methoxychalcone 40.3 µM -0.659050126357682 0.303767608271205 no 2337 0.25493179025127 3655 641818 SGTC_1480 1070-0044 41.2 µM -0.660882904720764 0.303148986858861 no 2338 0.254343705064621 3600 3124987 SGTC_2310 7668677 200 µM -0.660901461248656 0.303142726318285 no 2339 0.25433775445386 3654 2197143 SGTC_2592 piperlongumine 83.33 µM -0.661426131788216 0.302965738627481 no 2340 0.254169536043061 3569 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_247 mechlorethamine 29.705 µM -0.6616183225377 0.302900918285038 no 2341 0.254107930983484 3542 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1326 1431-2094 10.8 µM -0.661842037538822 0.302825473550849 no 2342 0.254036230967152 3601 616278 SGTC_804 1595-0054 20.9 µM -0.663539043138107 0.302253456524478 no 2343 0.253492691354581 3608 761523 Stimulates phospholipase C. SGTC_3252 9135871 49.47 µM -0.66387536216585 0.302140149604195 no 2344 0.253385043204882 3644 17682838 SGTC_526 4469-0568 170 µM -0.665980106341425 0.301431488285276 no 2345 0.252711908056126 3629 2901964 SGTC_3144 9087057 49.47 µM -0.666189336387965 0.301361082028831 no 2346 0.25264504401067 3566 17249618 SGTC_1464 k208-0027 110 µM -0.668054983059721 0.300733616463208 no 2347 0.252049247960273 3645 X1464 SGTC_457 grayanotoxin iii 135 µM -0.668873728700236 0.300458437237196 no 2348 0.251788014989848 3594 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3251 9135047 49.47 µM -0.669456730036453 0.300262560688283 no 2349 0.251602086918602 3606 17682963 SGTC_811 0416-0114 265 µM -0.670525669048825 0.299903569029395 no 2350 0.251261374356607 3639 6612453 SGTC_1684 st024538 14.6195 µM -0.672755648023594 0.299155280714469 no 2351 0.250551379161882 3615 6732859 SGTC_1635 st007035 42.4 µM -0.673275775570227 0.298980869463439 no 2352 0.250385930582168 3648 3716403 SGTC_2401 5128683 200 µM -0.673769433461497 0.298815376851098 no 2353 0.250228955377419 3582 708373 SGTC_369 0957-0393 4.5 µM -0.673955971518321 0.298752853147245 no 2354 0.250169652888819 3616 6997992 SGTC_2223 6903751 107.57 µM -0.674278694466142 0.298644697126015 no 2355 0.250067073340004 3601 5598863 SGTC_1545 lovastatin 49.4 µM -0.674490759476595 0.298573636238896 no 2356 0.249999679274407 3677 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_478 N-arachidonylglycine 10 µM -0.674622213005606 0.298529591323174 no 2357 0.24995790830287 3575 5283389 SGTC_2482 5981709 142.65 µM -0.675339488258529 0.298289312632865 no 2358 0.249730050550079 3622 877755 SGTC_2767 sibutramine 71.45 µM -0.676735119408942 0.297822045299535 no 2359 0.249287014903046 3690 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_977 1348-1378 135 µM -0.678154920730469 0.297347028463503 no 2360 0.248836735732172 3644 X977 SGTC_694 1315-0438 43.2 µM -0.678222399943726 0.297324460851169 no 2361 0.248815345997132 3585 6793154 SGTC_846 0335-0850 148 µM -0.678898610537727 0.297098353566988 no 2362 0.248601053083591 3622 6819598 SGTC_302 1094-0063 18.9 µM -0.681230026633912 0.296319392021884 no 2363 0.247862975655729 3593 5440289 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.682511392165815 0.295891667509319 no 2364 0.247457820859057 3616 77254 SGTC_282 k297-0036 65.7 µM -0.6831861789598 0.295666535235067 no 2365 0.247244602456412 3651 5061378 SGTC_3323 9138564 53.9225 µM -0.683806039754053 0.295459797582292 no 2366 0.247048826109611 3658 43912313 YNL103W MET4 SGTC_853 0419-0306 21 µM -0.684736833062136 0.295149481818164 no 2367 0.246755000922088 3617 762713 SGTC_2471 5466956 24.79 µM -0.685352943211036 0.294944160372153 no 2368 0.246560615292053 3614 724419 SGTC_2141 5621638 7.665 µM -0.687190871297332 0.294332054029626 no 2369 0.245981228086372 3662 2856238 SGTC_2951 9072950 58.06 µM -0.687443977763957 0.294247805046113 no 2370 0.245901496241817 3675 16488155 SGTC_2137 5261020 140 µM -0.687924261415354 0.294087968527878 no 2371 0.245750238753179 3641 763655 SGTC_617 3770-0098 35 µM -0.688566712537449 0.29387422607376 no 2372 0.245547987394874 3614 5962639 SGTC_1495 4469-0029 237 µM -0.688981354164429 0.293736313636 no 2373 0.245417500705265 3675 793680 SGTC_2917 7979103 53.79 µM -0.689832577294279 0.293453285314334 no 2374 0.245149739713668 3665 2980565 SGTC_3106 9121286 49.47 µM -0.693274144344084 0.292310267817433 no 2375 0.244068762900212 3684 15943471 SGTC_763 3453-1109 128 µM -0.694248070525769 0.291987182542809 no 2376 0.243763325538846 3672 1560353 SGTC_1197 1601-0112 267 µM -0.695141578575258 0.291690921090481 no 2377 0.243483290049316 3668 7350313 SGTC_38 0929-0051 58.268 µM -0.696394435010248 0.291275746216381 no 2378 0.243090923591399 3671 1379719 SGTC_2458 5808907 16.39 µM -0.696712413174272 0.291170417675628 no 2379 0.242991394413922 3729 2731747 SGTC_1753 st043925 64 µM -0.697439726588755 0.290929565940853 no 2380 0.24276382360839 3690 670181 SGTC_2997 9067075 71.4286 µM -0.698840882460244 0.290465832158478 no 2381 0.242325738028171 3684 27209819 SGTC_2499 avocadenofuran 51.48 µM -0.700170508931597 0.290026092325084 no 2382 0.241910413316027 3660 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2543 pimpinellin 60.67 µM -0.700425867640427 0.289941674722386 no 2383 0.241830693200291 3607 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1421 4029-0249 71.4 µM -0.700659628143073 0.289864407252408 no 2384 0.241757728301058 3753 2894095 SGTC_2114 5491910 81.25 µM -0.701542327356209 0.289572725949899 no 2385 0.241482314510308 3726 2849228 SGTC_2282 7944268 200 µM -0.701563962922329 0.289565578370736 no 2386 0.241475566068741 3702 2970414 SGTC_1180 1193-0155 285 µM -0.701918657808401 0.289448412303022 no 2387 0.241364946282205 3667 2921347 SGTC_3130 9127414 49.47 µM -0.703782294495746 0.288833164923826 no 2388 0.240784180780601 3689 1494646 SGTC_1848 st056003 16.4 µM -0.704311382616007 0.288658607899049 no 2389 0.240619439625953 3724 146492 SGTC_3009 9080819 71.4286 µM -0.706413228488944 0.287965657048149 no 2390 0.239965598360907 3698 17027216 SGTC_2144 5628481 200 µM -0.709694589265509 0.286885408512407 no 2391 0.238946774095573 3681 2818399 SGTC_1819 st053448 58.6 µM -0.71215724182923 0.286075948251314 no 2392 0.238183705569166 3654 2857616 SGTC_2364 9055074 200 µM -0.712692339889441 0.285900208102387 no 2393 0.238018078789834 3700 6470630 SGTC_488 nitrendipine 139 µM -0.713375949847591 0.285675767474816 no 2394 0.237806575589558 3723 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1912 st060209 90.8 µM -0.714116711723572 0.285432657588855 no 2395 0.237577506476464 3701 688787 SGTC_3237 9133362 49.47 µM -0.714917852481877 0.285169842955882 no 2396 0.237329902490187 3644 43845137 SGTC_817 1391-0715 46 µM -0.715321253584796 0.285037550690176 no 2397 0.237205279283876 3685 1353946 SGTC_1431 4049-0260 9.09 µM -0.71567672414263 0.284921001134041 no 2398 0.237095493122152 3674 3854841 SGTC_774 k060-0086 136 µM -0.717392045753551 0.284358911499295 no 2399 0.236566113119756 3722 5911235 SGTC_378 3970-0959 8.33 µM -0.718713969678908 0.283926095285056 no 2400 0.236158587074971 3713 6615653 SGTC_2058 5236698 133 µM -0.719552187748264 0.283651814509321 no 2401 0.235900379567855 3726 766665 SGTC_2464 5717415 7.67 µM -0.719708386119311 0.283600717486298 no 2402 0.235852280903911 3675 5285744 SGTC_1424 4048-1941 275 µM -0.720550588041325 0.2833252847989 no 2403 0.23559303215758 3791 X1424 SGTC_565 1418-0001 44.5 µM -0.720969179733468 0.283188436821275 no 2404 0.235464238699481 3731 2862145 SGTC_2024 5144227 134 µM -0.721275729352849 0.283088238287586 no 2405 0.235369943309635 3744 3475211 SGTC_823 0417-1665 178 µM -0.721842157814861 0.282903140764385 no 2406 0.235195763422776 3742 3429856 SGTC_2184 6075246 200 µM -0.723015574617672 0.282519876567802 no 2407 0.23483515782933 3757 2267320 SGTC_3117 9124945 49.47 µM -0.723067790557529 0.282502827476353 no 2408 0.234819118325977 3636 17592065 SGTC_162 k030-0015 37.8 µM -0.723872747440529 0.282240062620758 no 2409 0.234571931222615 3770 1809920 YMR134W ERG29 SGTC_110 0850-0284 111.64 µM -0.723872874357764 0.282240021200002 no 2410 0.234571892260073 3564 3906265 SGTC_3283 9109332 35.8195 µM -0.724485862805014 0.282040000200923 no 2411 0.234383751638574 3610 17027281 SGTC_3033 9090887 49.47 µM -0.72485977556925 0.281918024245428 no 2412 0.234269030002742 3745 19325384 SGTC_2674 ligustilide 100 µM -0.724881399335073 0.281910971025912 no 2413 0.234262396481558 3702 5319022 A signalling regulator. SGTC_1041 0206-0046 107 µM -0.726543081961627 0.281369219397302 no 2414 0.233752953323307 3749 50494 SGTC_720 r052-1644 49.9 µM -0.726635032738736 0.28133925573706 no 2415 0.233724780746816 3697 1422863 YOR257W CDC31 SGTC_794 k038-0031 316 µM -0.728207544507097 0.280827065674875 no 2416 0.23324327410502 3739 6624242 SGTC_589 1227-0070 34.1 µM -0.729327003280966 0.280462716522531 no 2417 0.232900829063388 3728 2841384 SGTC_3142 9086498 49.47 µM -0.730942384812714 0.2799373635541 no 2418 0.23240717276113 3693 25236367 SGTC_3265 9137266 49.47 µM -0.731064764272283 0.279897582866099 no 2419 0.232369797654095 3657 17224265 SGTC_1170 0310-0127 64.8 µM -0.73240856250602 0.279460948005774 no 2420 0.231959617056082 3732 774975 SGTC_2098 5376439 882.5 nM -0.733121348803733 0.27922947961592 no 2421 0.231742210122004 3764 2844116 SGTC_2704 st078022 71.1 µM -0.734205655210079 0.278877543526147 no 2422 0.231411703669744 3742 54697681 SGTC_1321 1326-2144 215 µM -0.735586002770282 0.278429833106508 no 2423 0.230991341733893 3731 3513030 SGTC_3111 9122088 49.47 µM -0.737996690732407 0.277648776684858 no 2424 0.230258230047628 3640 16876704 SGTC_192 3455-0609 60.9 µM -0.738695496205856 0.27742256585689 no 2425 0.230045960611781 3788 3769639 SGTC_397 arbidol 50 µM -0.7388635215374 0.277368187694056 no 2426 0.229994937503383 3797 131410 A RNA synthesis inhibitor. SGTC_2736 butenafine 14.65 µM -0.741154078423306 0.276627413283731 no 2427 0.22930001168448 3714 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_269 exalamide 29 µM -0.742263212539089 0.276269064046655 no 2428 0.228963937978023 3703 3316 A derivative of salicylamide. SGTC_139 0099-0334 718.624 µM -0.742287257354672 0.276261297949976 no 2429 0.22895665532946 3775 97690 SGTC_1626 st003712 1.76 µM -0.742535743816243 0.276181047011246 no 2430 0.228881401829699 3698 24207035 SGTC_228 caffeine 993.056 µM -0.743228543657706 0.27595736150716 no 2431 0.228671662463512 3736 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1879 gemcitabine 100 µM -0.744255181062673 0.275626052996408 no 2432 0.228361055119977 3743 60750 A nucleoside analog which inhibits DNA replication. SGTC_493 zm226600 134 µM -0.745270709314627 0.275298522068836 no 2433 0.2280540422321 3754 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1350 1495-0454 146 µM -0.746325684426163 0.274958471628137 no 2434 0.22773534981572 3760 1069057 SGTC_1256 0570-0116 285 µM -0.747389022497597 0.274615935108322 no 2435 0.227414384888634 3764 410638 SGTC_3085 9117376 49.47 µM -0.747419763258781 0.274606035619153 no 2436 0.227405109687412 3835 16480349 SGTC_2034 5197015 53.07 µM -0.747629370305969 0.274538540268914 no 2437 0.227341872056424 3734 780676 SGTC_2583 asiatic acid 100 µM -0.747640223363495 0.274535045709877 no 2438 0.227338598000985 3742 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1311 1190-0148 100 µM -0.748030777049205 0.274409306545435 no 2439 0.227220796862521 3822 1961333 SGTC_1145 3546-0597 10.2 µM -0.750742028764903 0.273537200636318 no 2440 0.226403961927091 3722 875334 SGTC_2701 st077767 14.721 µM -0.754865701875731 0.272213408178881 no 2441 0.225164783466931 3753 5721188 SGTC_642 0335-0876 158 µM -0.755675399645133 0.271953851324412 no 2442 0.224921918473471 3783 6812350 SGTC_256 clotrimazole 625 nM -0.755950531137792 0.271865683155521 no 2443 0.224839427903401 3728 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2327 6189656 200 µM -0.756385534580576 0.271726311718506 no 2444 0.224709039154809 3823 5349088 SGTC_2408 sulbentine 18.36 µM -0.757890035739801 0.271244556594593 no 2445 0.224258407948657 3776 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1515 3460-0031 42.1 µM -0.759576593993848 0.270705011766053 no 2446 0.223753857167946 3718 2876596 SGTC_2334 9017922 200 µM -0.759875317518208 0.270609503376128 no 2447 0.223664558356401 3821 3163164 SGTC_1034 k072-0165 12.7 µM -0.760149462543926 0.270521868078132 no 2448 0.223582624744673 3757 5835461 SGTC_1325 1431-0015 227 µM -0.760341573992343 0.270460464712219 no 2449 0.223525218648301 3727 1103340 SGTC_840 0245-0196 390 µM -0.760525501900611 0.270401683526015 no 2450 0.223470265786404 3864 3827528 SGTC_2049 5262831 67.185 µM -0.760630717272362 0.270368060807639 no 2451 0.223438833633554 3811 763417 SGTC_1679 SEC14.276 6.7 µM -0.761283428082765 0.270159526661065 no 2452 0.223243898316876 3817 1005053 YMR079W SEC14 SGTC_1144 3486-0183 12.5 µM -0.761829718727479 0.269985054487136 no 2453 0.223080820350991 3786 6744069 SGTC_1465 k213-0056 144 µM -0.762622533404626 0.269731948767884 no 2454 0.222844271056853 3673 24048857 YMR208W ERG12 SGTC_2139 5578692 56.4705 µM -0.76281622446134 0.269670131055387 no 2455 0.222786501875483 3713 650991 YMR113W FOL3 SGTC_825 1988-2224 89.6 µM -0.762897722811568 0.269644122468484 no 2456 0.222762197196975 3772 1180859 SGTC_1346 1488-2224 62.4 µM -0.762918853076007 0.269637379367571 no 2457 0.222755895913838 3742 3722427 SGTC_2524 avocatin b 10.57 µM -0.763127064120612 0.269570939469099 no 2458 0.222693810464507 3748 6710748 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.763889365785358 0.269327759925041 no 2459 0.22246658757624 3782 616764 SGTC_491 tetrandrine 80.3 µM -0.764041601272446 0.269279208924729 no 2460 0.22242122586359 3734 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2896 9052656 71.43 µM -0.764155443364921 0.269242905229389 no 2461 0.222387307704915 3723 6469436 SGTC_2863 9028737 58.44 µM -0.765537792193547 0.268802276824069 no 2462 0.221975685627554 3779 6460917 SGTC_3275 9138069 49.47 µM -0.76612581507051 0.268614952388191 no 2463 0.221800721994948 3882 17617007 SGTC_1290 0986-0249 10.2 µM -0.766644263574839 0.26844984646013 no 2464 0.221646525280466 3713 53329 SGTC_1976 st070609 63.5 µM -0.76720873992064 0.268270140474072 no 2465 0.2214787086645 3711 682556 SGTC_2738 aclarubicin 5.55 µM -0.768651692625596 0.267811039104513 no 2466 0.221050054776506 3717 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1429 4049-0205 9.46 µM -0.770217161728796 0.267313404986424 no 2467 0.220585542698172 3800 22774478 SGTC_16 erodoxin 22.806 µM -0.770525790881676 0.267215352484138 no 2468 0.220494031096079 3810 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_816 0325-0417 81.3 µM -0.772476953702634 0.266595882034004 no 2469 0.219915995754657 3815 68101 SGTC_2884 9058502 51.95 µM -0.772586891213615 0.266560999834521 no 2470 0.219883452477663 3776 6471554 SGTC_1001 4048-4355 44.4 µM -0.772966635567363 0.266440528069299 no 2471 0.219771063285873 3786 21824233 SGTC_843 0310-0051 143 µM -0.776540606810103 0.265308056902036 no 2472 0.218714927208924 3821 2065037 SGTC_1139 k015-0024 46.9 µM -0.777940216212022 0.264865234534934 no 2473 0.2183021291203 3772 2766652 SGTC_1002 4049-0206 172 µM -0.778751810470642 0.264608626454781 no 2474 0.218062964827937 3821 4662749 SGTC_1875 nocodazole 6 µM -0.779505457214723 0.26437045338575 no 2475 0.217841012084346 3768 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_368 fentichlor 4.58 µM -0.780317307711255 0.264114008485629 no 2476 0.21760206388736 3823 7329 A pesticide. SGTC_2842 9000675 19.48 µM -0.78033378884075 0.264108803788612 no 2477 0.217597214639824 3815 2989072 SGTC_719 2810-4230 27.3 µM -0.78070155860425 0.263992676665678 no 2478 0.217489021858861 3782 721079 SGTC_2541 muurolladie-3-one 83.07 µM -0.785208276888064 0.262571749903829 no 2479 0.216165731709091 3837 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2512 diallyl trisulfide 49.23 µM -0.78524060922936 0.26256156997398 no 2480 0.216156254965431 3827 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_621 3584-0052 32.1 µM -0.78526780636488 0.262553007034736 no 2481 0.216148283558246 3795 2273927 SGTC_2665 lovastatin 100 µM -0.785598025108633 0.262449050025391 no 2482 0.216051510916551 3824 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1005 4092-0690 4.4 µM -0.786801699151216 0.262070296801396 no 2483 0.215698979341591 3837 1529343 SGTC_1655 st012546 55.1 µM -0.787136497712061 0.261964997475854 no 2484 0.215600982982668 3769 720985 YLR208W SEC13 SGTC_2486 5283202 22.39 µM -0.787497788691014 0.261851390214922 no 2485 0.215495261195716 3870 1377751 SGTC_847 0342-0274 5.54 µM -0.788306304456408 0.261597245549413 no 2486 0.215258780443804 3826 18097 SGTC_2563 tomatine 8.54 µM -0.7885129714671 0.261532303232683 no 2487 0.215198357104567 3748 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1296 1068-0102 11.9 µM -0.788648258508449 0.261489795589955 no 2488 0.215158808495415 3832 767053 SGTC_336 4111-0029 111 µM -0.790106928166603 0.261031702101464 no 2489 0.214732662053645 3796 3131175 SGTC_2620 irigenin 100 µM -0.790472384039455 0.260916995783855 no 2490 0.214625971978726 3843 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1468 k284-1086 134 µM -0.791110307754416 0.260716831613581 no 2491 0.21443981231898 3813 15996457 SGTC_2569 tetrandrine 100 µM -0.79384996468882 0.259858096535637 no 2492 0.2136413905803 3846 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2879 9041815 71.43 µM -0.794235052407855 0.259737509323814 no 2493 0.213529302963109 3811 4942971 SGTC_1221 2958-7315 257 µM -0.795952498681911 0.259200056260633 no 2494 0.213029822688139 3840 4562705 SGTC_1359 1582-0056 520 nM -0.797017651349222 0.258867019265392 no 2495 0.21272038998547 3910 3661189 SGTC_1390 3413-2614 145 µM -0.797383549255065 0.258752666551451 no 2496 0.212614155219873 3879 3421432 SGTC_51 1013-0126 23.419 µM -0.798803880318864 0.258309023604373 no 2497 0.21220207010627 3861 1627850 SGTC_1057 3448-5381 134 µM -0.800277927789599 0.257849019428739 no 2498 0.211774894201602 3876 5497911 SGTC_971 1315-0384 26.7 µM -0.800700293927025 0.257717290546376 no 2499 0.211652586181489 3859 6769120 SGTC_2125 5246583 200 µM -0.800745277830285 0.257703262883644 no 2500 0.211639562261091 3817 835267 SGTC_1238 0333-0287 48.8 µM -0.800810546845452 0.2576829102695 no 2501 0.211620666147738 3830 7226 SGTC_1285 0929-0069 65.5 µM -0.800866049333868 0.257665603774618 no 2502 0.211604598330647 3850 1206237 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.800890028514456 0.257658126898966 no 2503 0.211597656645035 3873 115019 SGTC_183 3914-0051 30.55 µM -0.801848102118396 0.257359485061483 no 2504 0.211320414894954 3848 1596232 SGTC_205 1486-1330 71.903 µM -0.802755493821927 0.257076807263264 no 2505 0.211058035483611 3812 4118834 SGTC_2143 5623677 140.463 µM -0.803141332075882 0.256956656845642 no 2506 0.210946525219875 3788 5375313 SGTC_1734 st037168 69.4 µM -0.803404706825303 0.256874658466575 no 2507 0.210870427704521 3901 708907 SGTC_171 k064-0041 9.68 µM -0.803604156752449 0.256812571329731 no 2508 0.210812810858341 3852 53325 SGTC_1688 st021091 57.6 µM -0.804200244099422 0.256627060761606 no 2509 0.210640668930352 3860 3656366 SGTC_157 1348-1695 65.819 µM -0.805572400539183 0.256200292195472 no 2510 0.210244722364206 3805 5380510 SGTC_1747 st037496 66.6 µM -0.807178423817907 0.255701256713303 no 2511 0.209781847305634 3851 723305 SGTC_345 1362-0200 395 µM -0.808859860495813 0.255179332593869 no 2512 0.20929787976908 3838 1419823 SGTC_53 0973-0023 39.979 µM -0.809613831641157 0.254945478220257 no 2513 0.209081078001928 3759 674768 SGTC_2995 9067767 71.4286 µM -0.810725021216023 0.254601032246132 no 2514 0.208761800508859 3867 11673567 SGTC_2181 6316240 54.2555 µM -0.810998637176852 0.254516254327063 no 2515 0.20868322669137 3870 12779990 SGTC_1123 mangostin 811.285 nM -0.811148203826091 0.254469918439405 no 2516 0.208640283267409 3878 5281650 An antioxidant. SGTC_1241 0364-0022 50.8 µM -0.812590454049624 0.254023334889929 no 2517 0.208226453225915 3880 4563895 SGTC_1124 fisetin 1.16336 µM -0.814167977558532 0.253535336093466 no 2518 0.207774363777809 3873 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1475 4092-1048 11.7 µM -0.815334279441098 0.25317486353258 no 2519 0.207440496018328 3883 2881759 SGTC_1980 st071811 45.7 µM -0.815819469910414 0.253024983629053 no 2520 0.207301697943434 3975 4974850 SGTC_2930 9013230 14.89 µM -0.81689659516287 0.252692416431354 no 2521 0.206993761872364 3888 2995857 SGTC_2254 7938975 95.19 µM -0.817567072915703 0.252485519756352 no 2522 0.206802217776544 3912 2969277 SGTC_2507 purpurin 79.67 µM -0.818793716743369 0.252107231983143 no 2523 0.206452058197605 3870 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2288 7946289 167.31 µM -0.819161677757592 0.251993813883168 no 2524 0.206347088026657 3884 1246052 SGTC_1482 3346-2049 8.48 µM -0.819893658816753 0.251768272502786 no 2525 0.206138366010985 3869 3826804 SGTC_1725 st036284 20.55 µM -0.822981744524425 0.250817931893525 no 2526 0.205259187417974 3979 707914 SGTC_1302 1159-0335 255 µM -0.823834531697007 0.250555826590632 no 2527 0.205016791845695 3889 649284 SGTC_857 0438-0306 1.35 µM -0.824060679873111 0.250486343991509 no 2528 0.204952540217277 3939 4686136 SGTC_869 0564-0080 44.1 µM -0.824881866221458 0.250234125550199 no 2529 0.204719331209926 3882 6843321 SGTC_1140 3229-1848 2.98 µM -0.826890733555859 0.249617691967324 no 2530 0.20414949803059 3898 2849525 SGTC_2285 7945142 200 µM -0.827248965832308 0.249507850949041 no 2531 0.204047981587131 3915 2970608 SGTC_3070 9117005 49.47 µM -0.82880204937904 0.249031942365443 no 2532 0.203608214194826 3905 8779016 SGTC_1759 st043059 70 µM -0.828814801871633 0.249028036642345 no 2533 0.203604605570908 3884 669426 SGTC_2568 diosmetin 100 µM -0.828910997178525 0.248998575826245 no 2534 0.203577386028529 3910 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3198 9112019 49.47 µM -0.830035235690169 0.248654403592206 no 2535 0.203259431038544 3916 45595555 SGTC_1162 k048-0130 20.1 µM -0.832129159831332 0.2480140497046 no 2536 0.202668022074527 3845 6797406 SGTC_229 benomyl 22.8748 µM -0.834692945290155 0.247231204865208 no 2537 0.201945307379194 3899 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2627 acetyl isogambogic acid 100 µM -0.834973257980109 0.24714569235766 no 2538 0.201866382694304 3896 6857789 A caspase activator and apoptosis inducer. SGTC_371 0195-0006 7.36 µM -0.835545529873998 0.246971163569407 no 2539 0.20170531148637 3737 3928593 SGTC_1112 tnp00069 1.16933 µM -0.837949936516325 0.246238600160627 no 2540 0.201029410602503 3910 145826 SGTC_355 1311-2252 105 µM -0.83891267077523 0.245945605750098 no 2541 0.200759158468664 3888 5338538 SGTC_407 eburnamonine 100 µM -0.838990357557415 0.245921971048113 no 2542 0.200737360282244 3756 3195 SGTC_659 k018-0002 107 µM -0.839051962751848 0.24590322972491 no 2543 0.200720075449355 3868 6797879 YHR007C ERG11 SGTC_1168 k815-0004 80.5 µM -0.839554797576502 0.245750287685707 no 2544 0.200579026340786 3855 642433 SGTC_1952 st077036 64.1 µM -0.839566824350467 0.245746630252419 no 2545 0.200575653465378 3889 2937007 SGTC_2572 astragaloside iv 100 µM -0.84013899001086 0.245572664102829 no 2546 0.200415230545786 3952 45006101 An anti-inflammatory agent. SGTC_702 1488-0190 94 µM -0.840995976149729 0.245312222486247 no 2547 0.200175094323433 3932 949357 SGTC_2849 9019321 12.99 µM -0.841740660798137 0.245086030374233 no 2548 0.199966566605022 3907 16489627 SGTC_3344 9148862 3.898 µM -0.843042082476441 0.244691003242168 no 2549 0.199602454289416 3923 4905352 SGTC_1498 4478-3555 97.6 µM -0.844158891304315 0.244352286107097 no 2550 0.199290311357612 3845 3437919 SGTC_2864 9034755 47.6 µM -0.844926783315479 0.244119538698607 no 2551 0.199075859715014 3859 4930451 SGTC_134 0269-0018 6.916 µM -0.84508069209744 0.244072903465904 no 2552 0.199032893852295 3856 4378915 SGTC_842 0271-0008 11.1 µM -0.845672913435695 0.243893501871055 no 2553 0.198867618821343 3953 1221709 SGTC_1394 3474-0001 65.7 µM -0.846084283089692 0.243768927564444 no 2554 0.198752863941372 3891 5017666 YIL048W NEO1 SGTC_1031 k035-0009 16 µM -0.847546887440155 0.243326288097457 no 2555 0.198345182107535 3983 5180959 SGTC_304 1310-0298 97 µM -0.847855713972962 0.243232881066396 no 2556 0.19825916532226 3795 1550234 SGTC_490 phenamil 164 µM -0.848116413059419 0.243154045652788 no 2557 0.198186570899254 3872 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2893 9048488 25.97 µM -0.849677577743274 0.24268223861039 no 2558 0.19775218391833 3941 6467338 SGTC_3129 9127257 49.47 µM -0.850988024670331 0.242286585116797 no 2559 0.197388002540498 3901 837894 SGTC_1391 3442-0225 151 µM -0.851744988399902 0.242058200076513 no 2560 0.197177822534513 3856 5227075 SGTC_2915 7971052 15.16 µM -0.851762103978476 0.242053037451116 no 2561 0.19717307175605 3762 5741558 SGTC_2936 9038235 15.59 µM -0.852946772309978 0.241695847385133 no 2562 0.196844411180795 3862 4749415 SGTC_2780 5215298 71.43 µM -0.85337861927268 0.241565712139899 no 2563 0.196724687138809 3939 2834131 SGTC_2115 tiliquinol 12.7705 µM -0.853752871653145 0.24145296355846 no 2564 0.196620966138162 3901 71208 A bioactive hydroxyquinoline. SGTC_2229 7354935 190 µM -0.854404381775264 0.241256755550294 no 2565 0.196440484463936 3829 318112 SGTC_1116 jasmonic acid  1.58368 µM -0.85560262190802 0.24089612132862 no 2566 0.196108809601211 3974 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3260 9137109 49.47 µM -0.855986844302745 0.240780544072577 no 2567 0.196002528159032 3815 17478346 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.857492137999826 0.240328030162754 no 2568 0.195586478981066 3892 688667 SGTC_1673 st016611 27.3 µM -0.857662818249851 0.240276750375935 no 2569 0.19553933841884 3960 5226799 SGTC_1951 sophoraflavanone G 9.2 µM -0.858649828758946 0.239980326354107 no 2570 0.195266869103038 3895 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1850 st056238 17 µM -0.859678108551707 0.239671720347634 no 2571 0.194983252688075 3923 5393177 SGTC_1444 4112-3581 28 µM -0.860245440147527 0.239501546277924 no 2572 0.19482688060824 3941 2877249 SGTC_2322 7413319 38.22 µM -0.860696706029343 0.239366233846175 no 2573 0.194702553888767 3990 1840400 SGTC_2675 theaflavin digallate 100 µM -0.862478772413513 0.238832288094707 no 2574 0.194212054723861 3872 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_772 k072-0172 35.3 µM -0.862889132200846 0.23870942774432 no 2575 0.194099213247559 3971 5861980 SGTC_19 0279-0214 38.434 µM -0.86298008150344 0.238682202508958 no 2576 0.194074209251967 3968 3566274 YBR002C RER2 SGTC_1728 st035614 33.7865 µM -0.863177277428452 0.238623178695387 no 2577 0.194020002426013 3916 15945546 SGTC_2429 5902844 64.44 µM -0.863203604481859 0.238615299202468 no 2578 0.194012766128696 3967 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_657 3534-0529 86.7 µM -0.8638644793008 0.23841755090209 no 2579 0.193831170865519 3970 1049549 SGTC_226 1,3-diallylurea 8.28947 mM -0.864475266150297 0.238234869846435 no 2580 0.193663430939327 3893 74537 YKL182W FAS1 SGTC_2200 6600604 21.907 µM -0.866339266839819 0.237677837787124 no 2581 0.19315206936228 3890 2904777 SGTC_1055 3448-0672 86 µM -0.866581094431956 0.23760562319823 no 2582 0.193085787924361 3962 748378 SGTC_3243 9134147 49.47 µM -0.86675128205779 0.237554808965041 no 2583 0.193039150289259 3975 24282180 SGTC_244 nsc-207895 1.295 µM -0.867228233403822 0.237412433703144 no 2584 0.192908484827455 3744 42640 SGTC_973 1325-0077 65.9 µM -0.867794065589758 0.237243587300616 no 2585 0.192753539673445 3939 2835149 SGTC_703 3875-0075 71.8 µM -0.869335742393409 0.236783880131712 no 2586 0.192331759238267 3955 2850814 SGTC_3176 9106582 49.47 µM -0.870710214985222 0.236374444393546 no 2587 0.191956199772509 3858 17018027 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.871260572857486 0.236210609992273 no 2588 0.19180594648867 3929 442882 SGTC_547 1120-0019 610 nM -0.871329786799149 0.236190010327592 no 2589 0.191787055478945 3866 3676939 SGTC_411 enrofloxacin 100 µM -0.871589743097678 0.236112650177913 no 2590 0.191716114096302 4032 71188 A bacterial gyrase inhibitor. SGTC_1122 capsaicin 818.572 nM -0.872022113070088 0.235984012526975 no 2591 0.191598157076854 4033 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1239 0337-0584 35.4 µM -0.872550175084645 0.235826957218179 no 2592 0.191454154148658 4015 914301 YML130C ERO1 SGTC_1222 0366-0074 1.18 µM -0.87308602592241 0.235667644295372 no 2593 0.191308095012738 3981 286520 SGTC_1410 3909-8106 77.9 µM -0.875472500286165 0.234958846927896 no 2594 0.190658433361942 3970 1039210 SGTC_2630 antimycin a 100 µM -0.87572716204112 0.234883280458834 no 2595 0.190589187724387 3919 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_879 0831-1030 162 µM -0.876322100392792 0.234706795151918 no 2596 0.190427476904828 3968 1549252 SGTC_855 0428-0020 25 µM -0.877021601633163 0.234499385634492 no 2597 0.190237452547154 3961 6812414 SGTC_1208 2323-2347 50.3 µM -0.877206928225013 0.234444451335228 no 2598 0.190187126822062 3949 5412760 SGTC_1739 st037196 92.5 µM -0.878135434439129 0.234169331800143 no 2599 0.189935112686186 4002 612214 SGTC_1977 st070720 65.3 µM -0.878204168686266 0.234148972718688 no 2600 0.189916465076996 3968 682188 SGTC_80 0159-0065 512.242 µM -0.879126836970062 0.233875773312012 no 2601 0.18966625404081 3833 1548079 SGTC_3042 9091578 49.47 µM -0.879348521436949 0.233810159510208 no 2602 0.189606167427974 3887 25236497 SGTC_259 usnic acid 108.925 µM -0.880157097479615 0.233570924997219 no 2603 0.189387105670784 4025 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1745 st081495 74 µM -0.880973660480403 0.233329465197071 no 2604 0.189166038225723 3858 13842402 YBL026W LSM2 SGTC_743 1275-0778 158 µM -0.881605928332271 0.233142597136755 no 2605 0.188994974058537 3940 2849257 YMR203W TOM40 SGTC_456 gingerol 170 µM -0.881993740644182 0.233028019534616 no 2606 0.188890096088753 3947 442793 A herb. SGTC_2845 9003024 42.97 µM -0.883100619463653 0.232701168650828 no 2607 0.188590954754294 4012 2990173 SGTC_1104 tacrolimus 29.8 µM -0.883590995809055 0.232556446625083 no 2608 0.188458520715003 3968 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2575 plumbagin 510 nM -0.884034451187352 0.232425615222833 no 2609 0.188338807838015 3853 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3143 9086658 49.47 µM -0.885875370481227 0.231882931887683 no 2610 0.187842344727758 4032 25236626 SGTC_1422 4031-0024 15.5 µM -0.886203916340954 0.231786154346526 no 2611 0.187753826829428 3904 782427 SGTC_658 3253-0951 102 µM -0.886700894008751 0.231639805753239 no 2612 0.187619978455376 3956 1184878 SGTC_2286 7945697 125 µM -0.887239583520085 0.23148123215166 no 2613 0.187474962652598 3980 1245733 SGTC_2707 st078556 66.6 µM -0.890733657661962 0.230454155079896 no 2614 0.186536036844417 3922 17250899 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.891050926217824 0.230361020859045 no 2615 0.186450925058354 4038 4213774 SGTC_1720 st037298 9.481 µM -0.893566809521726 0.229623228600026 no 2616 0.185776855646634 3989 597396 SGTC_2183 6420625 130.508 µM -0.895285622722625 0.229119942180363 no 2617 0.185317211936444 3940 2897619 SGTC_1756 st041558 35.5 µM -0.896244173909572 0.22883953736097 no 2618 0.185061183876676 4056 3955792 SGTC_933 2914-0560 114 µM -0.896951998921725 0.22863260112177 no 2619 0.184872265641453 4018 463887 SGTC_82 0054-0107 293.755 µM -0.897027004465315 0.228610679029624 no 2620 0.184852253715189 3930 3104697 SGTC_1155 4088-0394 48.2 µM -0.897161958661902 0.228571238540303 no 2621 0.184816250521484 3952 2326248 SGTC_2887 9044784 58.44 µM -0.897934083169468 0.228345657935885 no 2622 0.184610346312998 3952 6465546 SGTC_94 0334-0113 514.748 µM -0.900945146726645 0.227467154803782 no 2623 0.183808742713465 3993 6795178 SGTC_2272 7805186 180 µM -0.902880168464392 0.226903602179684 no 2624 0.183294748475039 3980 2956062 YPR165W RHO1 SGTC_1384 3089-0840 101 µM -0.903845781105346 0.2266226735148 no 2625 0.183038591129026 3953 1069836 SGTC_1571 st070080 73.4 µM -0.904375912622495 0.22646852423265 no 2626 0.182898053064457 4033 4315245 SGTC_1726 st035556 14.5795 µM -0.90516434133086 0.226239377984145 no 2627 0.182689164910784 4096 5919439 SGTC_1810 st050138 53 µM -0.906581379361721 0.225827864323269 no 2628 0.18231410614946 3949 3444541 SGTC_1583 clindamycin 39.6 µM -0.907277054517199 0.225625992432944 no 2629 0.182130152470397 3953 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_745 0469-0705 296 µM -0.908723613451626 0.225206555228528 no 2630 0.18174801820972 4066 3486736 SGTC_1945 st075991 56.6 µM -0.909142770467802 0.225085101077081 no 2631 0.181637384228987 4007 1084980 SGTC_536 3852-0578 10.6 µM -0.911923141378805 0.224280406210605 no 2632 0.180904589295933 4047 2869208 SGTC_1597 7-benzyloxygramine 47.5 µM -0.915939767738312 0.223120803527124 no 2633 0.17984924364922 3940 260807 SGTC_1088 bifonazole 369 nM -0.916408710011736 0.222985642479092 no 2634 0.179726284334771 3937 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2037 5169046 200 µM -0.916866890281251 0.222853628366076 no 2635 0.179606197903357 4052 5718022 SGTC_1837 st055472 66.5 µM -0.917163456606829 0.222768203340769 no 2636 0.179528496451664 4100 676091 SGTC_1942 st076330 65.2 µM -0.918849147533272 0.222282999834822 no 2637 0.179087240777719 4009 24208414 SGTC_634 1611-4317 11.2 µM -0.919350563565855 0.222138790396123 no 2638 0.178956119149284 3982 2843522 SGTC_1518 st038567 90.8 µM -0.919525823982888 0.222088397332371 no 2639 0.178910302335559 3956 77966 SGTC_2957 9076800 11.52 µM -0.923330546025079 0.220996025819074 no 2640 0.177917487037644 3970 16459615 SGTC_917 harmaline 728.087 nM -0.92469048663955 0.220606321372284 no 2641 0.177563464686372 3992 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_3105 9121040 49.47 µM -0.926862328427434 0.219984775758458 no 2642 0.176999009328954 3818 41448907 SGTC_3067 9117431 49.47 µM -0.926925286742072 0.219966773116198 no 2643 0.176982663573858 4052 17150885 SGTC_837 0091-0265 12.5 µM -0.926935877991459 0.219963744679922 no 2644 0.176979913880374 3948 759367 SGTC_792 4534-1957 155 µM -0.928632147144357 0.219479026412801 no 2645 0.17653987795792 3946 1717904 SGTC_3037 9091026 49.47 µM -0.930560454468889 0.218928747953725 no 2646 0.176040489299254 3972 25236398 YIL048W NEO1 SGTC_2423 st077119 87.2 µM -0.931744281204523 0.218591314462126 no 2647 0.175734348060641 3938 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2678 equilin 100 µM -0.932038911307648 0.218507380769203 no 2648 0.175658208256806 4018 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1793 st048256 72.231 µM -0.932885694267298 0.218266254106794 no 2649 0.175439494701801 3870 672022 SGTC_2766 oltipraz 83.91 µM -0.933096657114838 0.218206205000791 no 2650 0.175385032482385 3954 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1872 amphotericin b 148 nM -0.933142022299062 0.218193293360702 no 2651 0.175373322395945 4027 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1028 k015-0029 4.8 µM -0.933854942216038 0.217990443048677 no 2652 0.175189361934405 3957 4588309 SGTC_2453 5731132 22.18 µM -0.937010219915357 0.217093964231421 no 2653 0.174376650466931 4060 1362040 SGTC_3008 9078912 71.4286 µM -0.937164581415545 0.217050161701753 no 2654 0.174336952803759 3998 16648731 SGTC_1493 4348-0038 111 µM -0.938080860332923 0.216790258146123 no 2655 0.174101428503841 4002 800424 SGTC_1355 1499-0035 1.68 µM -0.938977000833423 0.216536241025857 no 2656 0.173871276403702 3996 1548538 SGTC_3164 9100705 49.47 µM -0.939332578298325 0.216435497914609 no 2657 0.173780008540321 4052 17174235 SGTC_511 blebbistatin 171 µM -0.940039812600027 0.216235203142457 no 2658 0.173598569740625 4096 3476986 A myosin inhibitor. SGTC_1973 st070275 50.2 µM -0.941040806612253 0.215951896644586 no 2659 0.173341973905131 3959 17118334 SGTC_1089 terbinafine 2.25 µM -0.941086380092646 0.215939003323193 no 2660 0.17333029730208 4018 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2054 5233173 129 µM -0.943661897607455 0.215211081575486 no 2661 0.17267122536033 4056 6889 SGTC_929 2805-0021 398 µM -0.943730675763825 0.215191662263258 no 2662 0.172653647040306 4095 3098024 SGTC_2487 5918373 44.05 µM -0.944759161774196 0.214901393576454 no 2663 0.172390922702902 4085 2876279 SGTC_2892 9047358 58.44 µM -0.9457870387742 0.214611524118635 no 2664 0.172128608866936 4021 6466771 SGTC_1820 st053765 18.6 µM -0.94613567674932 0.21451325708512 no 2665 0.172039694469145 4095 3690829 SGTC_2186 6124449 200 µM -0.946604919966294 0.21438103758786 no 2666 0.17192006797794 4021 3834182 YLR033W RSC58 SGTC_1956 st077085 54 µM -0.948155311006027 0.213944518277591 no 2667 0.171525196880235 4072 24208685 SGTC_55 0767-0285 6.563 µM -0.949685736880036 0.213514128173425 no 2668 0.171135979618417 3944 3116166 SGTC_46 0329-0187a 2.197 µM -0.95658406622851 0.211580436164138 no 2669 0.169388617178349 4096 46494817 SGTC_1369 1866-0067 208 µM -0.957374837084876 0.211359429620305 no 2670 0.169189047215382 4049 3531355 SGTC_3079 9117512 49.47 µM -0.957725200579039 0.211261552430415 no 2671 0.169100672878794 4078 7185044 SGTC_2872 9044037 25.97 µM -0.958441456522357 0.21106154255044 no 2672 0.168920099504919 4040 6465195 SGTC_3131 9127911 49.47 µM -0.959115956654506 0.210873294225952 no 2673 0.1687501663705 4101 45595681 SGTC_1659 st012954 42.1 µM -0.959148514122736 0.210864210153238 no 2674 0.168741966642972 4028 24207262 SGTC_1757 st041620 31.8375 µM -0.960621893971433 0.210453353012518 no 2675 0.168371158084462 4114 5289815 SGTC_1624 st003710 6.25 µM -0.96086713482528 0.210385012384694 no 2676 0.168309488721436 4087 24207033 SGTC_2292 7671323 168.05 µM -0.96263852023848 0.209891772093716 no 2677 0.16786447974885 4111 937504 SGTC_2946 9065502 71.43 µM -0.964087340495989 0.209488855465206 no 2678 0.167501069527908 3852 16489101 SGTC_899 1083-0020 478 µM -0.965752589041577 0.209026312699717 no 2679 0.167083998783808 4112 767123 SGTC_374 0880-0231 82.3 µM -0.965981596037731 0.208962750337206 no 2680 0.167026695129288 3970 6833587 SGTC_2264 7948757 110.76 µM -0.967495069039758 0.208542962525154 no 2681 0.166648302541401 4011 2971411 SGTC_1736 st036774 51 µM -0.968747442511882 0.208195971416871 no 2682 0.166335607662483 4124 1272247 SGTC_3261 9137475 49.47 µM -0.974111123553818 0.206713732276139 no 2683 0.165000683511847 3984 17027690 SGTC_4 0960-0234 25.671 µM -0.975083170416895 0.206445780046059 no 2684 0.164759502995955 4062 6821112 SGTC_2056 5235370 200 µM -0.975538333271567 0.20632038166036 no 2685 0.164646648288991 4017 5511916 SGTC_2696 st077691 74.316 µM -0.975608363552865 0.206301092168799 no 2686 0.164629289177505 4118 757133 SGTC_514 4466-0038 2.65 nM -0.976310733232552 0.206107687070328 no 2687 0.164455251324698 3906 5722064 SGTC_1787 fluconazole 80 µM -0.978003427431648 0.205642027365108 no 2688 0.16403631446289 3856 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1328 1441-0025 69.2 µM -0.979273708574056 0.205292983894543 no 2689 0.163722378737893 4041 4562601 SGTC_736 0958-0254 92.6 µM -0.980407053370336 0.204981864597561 no 2690 0.163442614731125 4162 6812352 SGTC_3263 9137018 49.47 µM -0.981749547881048 0.204613693610838 no 2691 0.163111624492123 4060 43844957 SGTC_291 SEC14.278 35.5 µM -0.981806716502439 0.204598024201628 no 2692 0.163097539321894 4114 1068044 SGTC_2076 5212012 200 µM -0.981923240810101 0.204566088139061 no 2693 0.16306883258158 4007 604802 SGTC_2006 4011487 200 µM -0.982573087448671 0.204388037707834 no 2694 0.162908797646989 4116 45595294 SGTC_1503 4585-0012 61.3 µM -0.983408262262262 0.204159345027259 no 2695 0.162703272747309 4130 2922052 SGTC_1999 st074831 12.5 µM -0.985691845500754 0.203534818835643 no 2696 0.162142176115475 4025 17112523 SGTC_510 ag-490 170 µM -0.986150313317966 0.203409572165889 no 2697 0.162029678572981 4178 5328779 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.986802379676312 0.203231516448477 no 2698 0.161869763959255 4121 688788 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.988143491395672 0.2028655999349 no 2699 0.161541189243916 4091 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2743 auranofin 4.32 µM -0.988544242253124 0.202756333220986 no 2700 0.161443089024993 4034 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1000 4048-0884 8.67 µM -0.98895297815855 0.202644925574634 no 2701 0.161343074162585 4125 13040088 SGTC_1198 1612-1005 86.7 µM -0.992551016532741 0.201665800920292 no 2702 0.160464402953495 4155 6998509 SGTC_1478 0453-0656 35.7 µM -0.994825397776082 0.201048343942206 no 2703 0.159910595731746 4078 5258496 SGTC_1708 st033234 31.827 µM -0.996507198653232 0.200592492884856 no 2704 0.159501885581368 4189 674664 SGTC_391 gliotoxin 8.33 µM -0.997766970798303 0.200251439338564 no 2705 0.159196184908522 4183 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_868 0527-0199 213 µM -0.999086913315486 0.199894470146862 no 2706 0.158876295046842 4036 2849450 SGTC_2111 5486399 200 µM -1.00082030270995 0.19942626884355 no 2707 0.158456846101028 4060 689674 SGTC_1305 1181-0477 144 µM -1.00128974548229 0.199299582576234 no 2708 0.15834337453491 4157 6252086 SGTC_305 1682-2595 20.8 µM -1.00251906986214 0.198968060406388 no 2709 0.158046480509372 4100 226033 SGTC_1243 0416-0003 5.65 µM -1.00262901329772 0.198938427240871 no 2710 0.158019945893924 4088 2141977 SGTC_776 4476-4378 112 µM -1.0037831170968 0.198627521010503 no 2711 0.157741581881952 4152 2892008 SGTC_1329 1447-1697 50.6 µM -1.00888611577864 0.197256330502716 no 2712 0.156514627306485 4096 2840515 SGTC_2545 solidagenone 89.61 µM -1.00941201653035 0.19711534566014 no 2713 0.156388538930458 3904 6708572 An anti ulcer agent SGTC_2790 5423970 71.43 µM -1.00951712925992 0.197087174079466 no 2714 0.156363345443828 4163 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_93 0109-0045 59.227 µM -1.00976154455323 0.197021677017886 no 2715 0.156304774163961 4208 88733 SGTC_203 k066-0004 30.888 µM -1.01032149870684 0.196871673266663 no 2716 0.156170642157059 4183 6795412 SGTC_647 0140-0236 81 µM -1.01136008930098 0.196593632754321 no 2717 0.155922057915718 4104 990837 SGTC_325 2810-4341 181 µM -1.01154964731332 0.196542911968157 no 2718 0.155876715809271 4095 774970 SGTC_180 1486-1293 102.781 µM -1.01337400357846 0.19605516722659 no 2719 0.155440775874904 3986 4140536 SGTC_730 1436-0052 41.2 µM -1.01433129357912 0.195799528079275 no 2720 0.155212348289348 4136 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2301 7769476 200 µM -1.01466252420816 0.195711121850837 no 2721 0.155133361992874 4129 977820 SGTC_1378 2093-0007 380 nM -1.01534581839457 0.195528825601975 no 2722 0.154970505365489 4183 3618014 SGTC_751 0833-0568 350 µM -1.017896102591 0.194849345704488 no 2723 0.154363667001609 4144 6954252 SGTC_1731 st035964 63 µM -1.01813214994982 0.194786527589295 no 2724 0.154307579245131 4048 6739575 SGTC_1455 4262-0120 131 µM -1.01841453416772 0.194711394260615 no 2725 0.154240498986953 4187 1529587 SGTC_3207 9114163 49.47 µM -1.01879930501076 0.19460904753781 no 2726 0.154149127873521 4162 849233 SGTC_497 capsazepine 133 µM -1.01950639446019 0.194421051385268 no 2727 0.153981309484049 4077 2733484 A calcium channel blocker. SGTC_3307 9126885 69.2785 µM -1.02257988299404 0.193605178516862 no 2728 0.153253262588085 4088 24824909 SGTC_935 2996-0153 430 µM -1.02298500395902 0.193497793099588 no 2729 0.153157468094485 4145 23738523 SGTC_584 0986-0246 15.4 µM -1.0251550575506 0.192923195767033 no 2730 0.152645015142794 4202 53315 YDR232W HEM1 SGTC_1048 3161-0300 24.5 µM -1.02611904556374 0.192668280982984 no 2731 0.152417736981362 4097 2165101 SGTC_875 0709-0210 25.7 µM -1.02630758962535 0.192618446900089 no 2732 0.1523733104738 4127 6251364 SGTC_555 4296-0685 37 µM -1.02784606701721 0.192212106391601 no 2733 0.152011121332085 4079 2908540 YHR072W ERG7 SGTC_20 0481-0013 4.944 µM -1.02872678822136 0.191979727721751 no 2734 0.151804039072832 4149 182045 SGTC_2462 5162487 171.77 µM -1.0291296250786 0.191873496376195 no 2735 0.151709383334828 4006 2259986 SGTC_892 0929-0076 29 µM -1.02972518189944 0.191716509155091 no 2736 0.15156951550844 4101 5751038 SGTC_1550 gossypolone 36.6 µM -1.0300990161087 0.191618007629112 no 2737 0.151481763529889 4135 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1244 0416-0015 52.5 µM -1.03627436737273 0.18999535371321 no 2738 0.150037080458467 4094 96201 SGTC_718 1130-0073 349 µM -1.0365844291688 0.189914104247506 no 2739 0.14996478653077 4171 6740020 SGTC_2104 5389443 200 µM -1.0371644063128 0.189762182762654 no 2740 0.149829621580742 4171 2244536 SGTC_109 0132-0036 33.701 µM -1.03996576739395 0.189029436120542 no 2741 0.149177902604386 3937 67274 A color developer. SGTC_638 3970-0837 4.09 µM -1.04037187660921 0.188923355739894 no 2742 0.149083581213295 4096 4118451 YLR208W SEC13 SGTC_2246 7293507 91.5585 µM -1.04061596426657 0.188859614897348 no 2743 0.149026909506945 4179 887656 SGTC_227 fluconazole 33.516 µM -1.04315748699736 0.188196711399355 no 2744 0.14843767974488 4128 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_628 1636-0253 16 µM -1.04340217505498 0.188132965453727 no 2745 0.148381033300023 4134 4456143 SGTC_696 1560-0013 611 µM -1.04371584168823 0.188051268754975 no 2746 0.14830843913772 4200 1650269 SGTC_838 0109-0203 71.4 µM -1.04391291625564 0.187999950489884 no 2747 0.148262840884466 4140 759422 SGTC_2629 bisabolol 100 µM -1.04836778286281 0.186842209717773 no 2748 0.147234595491583 4186 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_403 arphamenine a 50 µM -1.04864248024467 0.186770965462588 no 2749 0.147171348344333 4105 5487158 An arginine aminopeptidase inhibitor. SGTC_1594 piperine 70.1 µM -1.05301562917768 0.185639031241769 no 2750 0.146166914515877 4123 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2276 7947513 42.08 µM -1.05311141357429 0.18561428639463 no 2751 0.146144966211791 4098 2105100 SGTC_1611 st001856 99.4 µM -1.05396202575557 0.185394629877005 no 2752 0.14595015168451 4121 647478 SGTC_1172 0370-0043 85 µM -1.05445340639955 0.185267812525292 no 2753 0.145837691011942 4170 376585 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.05452355428587 0.18524971289167 no 2754 0.145821641247636 4161 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1190 1486-1332 13 µM -1.05597677153491 0.18487499923575 no 2755 0.145489413675081 4134 4150046 SGTC_2333 9017922 200 µM -1.05810977566655 0.184325855598386 no 2756 0.14500269908041 4187 3163164 SGTC_2934 9036370 36.88 µM -1.05829567658617 0.184278043385825 no 2757 0.144960331697139 4146 6462800 SGTC_2689 tacrolimus 100 µM -1.05839367182507 0.184252842909759 no 2758 0.144938001639727 4170 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1665 st014639 11.4 µM -1.06108197204741 0.183562355651521 no 2759 0.144326325007907 4205 981133 YIL048W NEO1 SGTC_1716 st033144 30.6155 µM -1.06414186577286 0.182778390203293 no 2760 0.143632218834675 4178 674617 SGTC_1644 st010134 20.9 µM -1.06475918577365 0.18262048238733 no 2761 0.143492459551434 4139 3818134 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.06525631742178 0.182493380183307 no 2762 0.143379977283677 4130 15053 SGTC_1075 aripiprazole 15.2 µM -1.06889495467492 0.181564768800074 no 2763 0.142558502824694 4208 60795 An atypical antipschotic. YIL048W NEO1 SGTC_64 000l-0018 272.079 µM -1.06931406592616 0.181457998279015 no 2764 0.142464087288151 4091 6811119 SGTC_3304 9125678 46.087 µM -1.0693909439147 0.181438417524379 no 2765 0.142446773145225 4095 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_793 0488-0545 106 µM -1.07229149540359 0.180700616278373 no 2766 0.141794562734412 4196 292548 SGTC_1628 st004252 77.7 µM -1.07441554278784 0.180161526049885 no 2767 0.14131823968561 4201 692968 SGTC_3012 9080433 71.4286 µM -1.07642683291838 0.179651985577635 no 2768 0.140868203596 4180 17688859 SGTC_2018 5133068 143 µM -1.07665838474704 0.179593382393792 no 2769 0.140816455212074 4126 785362 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.07838376562901 0.179157086107972 no 2770 0.1404312644262 4102 1241132 A phosphatase inhibitor. SGTC_548 1436-0017 110 µM -1.08023003513837 0.178690959865008 no 2771 0.140019878322564 4239 9677137 SGTC_2140 5586273 200 µM -1.08067769301503 0.178578055146932 no 2772 0.139920254585064 4141 854421 SGTC_2601 securinine 100 µM -1.08153938271401 0.17836085311327 no 2773 0.139728626034722 4145 442872 A GABA receptor antagonist. SGTC_2313 7726885 200 µM -1.08409350611562 0.177718025774855 no 2774 0.139161670918806 4210 726423 SGTC_237 nikkomycin 200 µM -1.08591695384408 0.177259991921243 no 2775 0.138757867706455 4192 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_182 3448-4371 550.524 µM -1.08736616804762 0.176896494397107 no 2776 0.138437508367006 4039 3491403 SGTC_1818 st052136 56.3 µM -1.08744582891128 0.176876527219183 no 2777 0.138419913380855 3895 674169 SGTC_1065 prochlorperazine maleate 2.48 µM -1.08827550218633 0.176668652394475 no 2778 0.138236751009062 4215 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2231 micatex 6.853 µM -1.09287672278142 0.175518621095369 no 2779 0.137223964835795 4201 20737 An antifungal of unknown mechanism. SGTC_352 k048-0007 5.11 µM -1.09427751853675 0.175169449769643 no 2780 0.136916641079032 4158 6811911 SGTC_1926 methyl fluorone black 53.6 µM -1.09490214229525 0.175013894175723 no 2781 0.136779755210303 3877 72721 Reacts with homocysteine. SGTC_675 1309-0189 238 µM -1.09571043974318 0.174812726827534 no 2782 0.136602756285842 4211 4246530 SGTC_402 epigallocatechin gallate 10 µM -1.1014200825327 0.173395905688156 no 2783 0.135356934483667 4134 65064 An antioxidant. SGTC_2735 sertaconazole 140 nM -1.10162774520344 0.173344513311683 no 2784 0.135311770543313 4317 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2463 5473429 200 µM -1.10366028600637 0.172842011980453 no 2785 0.134870264588413 4177 5399405 SGTC_296 1222-0039 74.9 µM -1.10421112273488 0.172705989672612 no 2786 0.134750782927238 4203 5984176 SGTC_322 k048-0136 19.3 µM -1.10428151588139 0.172688611875713 no 2787 0.134735519228043 4262 6823282 SGTC_428 3448-4153 16.5 µM -1.1043021723869 0.172683512662463 no 2788 0.134731040399462 4176 3834874 SGTC_279 1273-0055 2.93 µM -1.10468665263182 0.172588618352925 no 2789 0.134647694457313 4210 2847562 SGTC_667 1498-1044 59 µM -1.10614636363821 0.172228647097453 no 2790 0.134331586936152 4210 6739982 SGTC_1860 st056228 74.6 µM -1.10660023158939 0.17211681894246 no 2791 0.13423340356827 4171 688679 SGTC_3052 9092717 49.47 µM -1.10676084015507 0.1720772578324 no 2792 0.134198671594451 4206 25237534 SGTC_3167 9103034 49.47 µM -1.106835945576 0.17205875985317 no 2793 0.134182431991841 4269 5127859 SGTC_766 1391-0721 126 µM -1.10713924886607 0.171984071128944 no 2794 0.134116864241812 4226 1020919 YIL115C NUP159 SGTC_1310 1188-0297 994 nM -1.10820976932051 0.171720619932602 no 2795 0.133885616344464 4070 1588352 SGTC_2751 anetholtrithion 17.25 µM -1.1090299117955 0.17151896033816 no 2796 0.133708639204245 4196 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1882 5615643 20 µM -1.11127940223293 0.170966624645431 no 2797 0.133224051307718 4155 2253075 SGTC_767 0929-0023 86 µM -1.11216241252935 0.17075012328846 no 2798 0.133034162885579 4209 1204563 SGTC_3341 9147222 25.867 µM -1.11220524484154 0.170739625889013 no 2799 0.133024956679707 4209 1939759 SGTC_3015 9080845 49.47 µM -1.11307565697813 0.170526393625995 no 2800 0.132837968779963 4249 5296973 SGTC_3035 9091303 49.47 µM -1.11446880141166 0.170185458226774 no 2801 0.132539060774917 4274 25237002 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.11601529683364 0.169807506111385 no 2802 0.132207793439622 4216 521171 SGTC_1288 0973-0013 65.5 µM -1.11717524831911 0.169524376029679 no 2803 0.131959700746328 4241 4315430 SGTC_1962 st076595 64.5 µM -1.11839918090174 0.169225957553751 no 2804 0.131698272007844 4183 279619 SGTC_2225 6654152 15.4 µM -1.1190382978387 0.169070262580443 no 2805 0.131561900464143 4107 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2702 st077768 96.8 µM -1.1203524061458 0.168750422417855 no 2806 0.131281808983735 4200 6484119 SGTC_128 0906-2981 13.371 µM -1.12090880488812 0.168615118052238 no 2807 0.131163341302314 4197 6740226 SGTC_503 tyrphostin 8 294 µM -1.12280614998037 0.168154248523008 no 2808 0.130759916432604 4224 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2397 5161689 200 µM -1.12296321463247 0.168116133511369 no 2809 0.13072655888774 4285 2259942 SGTC_2250 alverine citrate 130 µM -1.12341144189959 0.168007392393654 no 2810 0.13063139629052 4099 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_515 4092-1064 102 µM -1.12352405133408 0.16798008016428 no 2811 0.130607495845523 4237 717353 SGTC_1261 0712-0010 12.7 µM -1.12534063105341 0.16753988285785 no 2812 0.130222359199864 4231 2840123 SGTC_1115 galangin 695.678 nM -1.1261925756639 0.167333694110724 no 2813 0.130042007692408 4282 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_23 0213-0011 39.996 µM -1.12671810914471 0.167206585400481 no 2814 0.129930841695566 4223 627608 SGTC_1472 k841-0093 193 µM -1.12898142546373 0.166659877473311 no 2815 0.129452834688965 4327 X1472 SGTC_2865 9030313 51.95 µM -1.13153385039666 0.166044720501993 no 2816 0.128915232146524 4179 42562754 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.13181241782958 0.165977672197712 no 2817 0.12885665295234 4257 6728940 SGTC_1382 3002-2117 298 µM -1.13326843999464 0.165627507460252 no 2818 0.128550770455149 4294 1497314 SGTC_3318 9139014 38.6185 µM -1.13401668638544 0.165447744590385 no 2819 0.128393774339161 4227 16643984 SGTC_796 1234-0020 70.7 µM -1.13576917875237 0.165027210275977 no 2820 0.12802658971568 4166 46495034 SGTC_2 0422-0095 29 µM -1.13758952271777 0.164591127493919 no 2821 0.12764596180402 4133 6790840 SGTC_1985 st071382 65.5 µM -1.13955080614326 0.164122117649187 no 2822 0.127236745101198 4218 6123237 SGTC_2391 6285546 200 µM -1.14022590295417 0.163960879691545 no 2823 0.127096099276853 4222 846083 SGTC_1419 3993-2473 62.6 µM -1.1409046460904 0.163798874505742 no 2824 0.126954802898471 4302 704026 SGTC_1714 st033236 13.627 µM -1.14199148274773 0.163539680339868 no 2825 0.126728780015459 4275 2916566 SGTC_1906 st060206 94.7 µM -1.14277502225599 0.163352983287779 no 2826 0.126566005937814 4256 5133468 SGTC_1240 0356-0016 42.1 µM -1.14434274889205 0.16297985069779 no 2827 0.126240760567717 4206 4305613 SGTC_2102 5377816 72.7585 µM -1.147179390447 0.162306114768877 no 2828 0.12565374376885 4295 1379702 SGTC_1473 k844-0725 134 µM -1.14857343664958 0.161975677698523 no 2829 0.125365957783699 4288 54682906 SGTC_1319 1306-0155 43.7 µM -1.15033839773667 0.161557950071501 no 2830 0.12500226082936 4292 3122360 SGTC_798 1287-0182 476 µM -1.15782923670307 0.15979285596018 no 2831 0.123466864846577 4297 1649755 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.15803981565358 0.159743419465923 no 2832 0.123423894256561 4272 94937 An inhibitor of serotonin biosynthesis. SGTC_1091 telmisartan 47.6 µM -1.16209674113688 0.158792950481211 no 2833 0.122598085518902 4287 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1546 5-methoxyflavanone 78.7 µM -1.16226023337702 0.158754724881959 no 2834 0.122564887255169 4266 147795 SGTC_1481 3346-2004 36 µM -1.16360835082943 0.158439755805744 no 2835 0.122291382822713 4322 2770522 SGTC_2263 7948595 193.29 µM -1.16481274934476 0.15815871160381 no 2836 0.122047398505451 4260 2971371 SGTC_2442 5158906 48.48 µM -1.16503035503379 0.15810796863157 no 2837 0.122003352925082 4253 1893835 SGTC_2355 9061122 103.12 µM -1.16555417828348 0.157985863315317 no 2838 0.121897371615361 4266 5302957 SGTC_1274 0865-0114 173 µM -1.16810341736099 0.157392509426567 no 2839 0.121382526022711 4248 870624 SGTC_2217 6934799 96.0675 µM -1.16819396643815 0.157371460445663 no 2840 0.121364266846194 4230 675606 SGTC_2526 patulin 37.61 µM -1.16857021113337 0.157284018661905 no 2841 0.121288417974278 4284 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_500 h-89 112 µM -1.16865562467354 0.157264172433554 no 2842 0.12127120371567 4259 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1680 diphenhydramine 100 µM -1.17232585947584 0.156412931962092 no 2843 0.120533126606078 4241 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1414 3917-0015 5.4 µM -1.17339785603971 0.156164876589606 no 2844 0.120318148293272 4246 6618702 SGTC_445 e6 berbamine 66 µM -1.17463723471507 0.155878412958723 no 2845 0.120069939982263 4286 6610268 A calcium/calmodulin antagonist. SGTC_1520 flindersine 88 µM -1.1767785006161 0.155384308520351 no 2846 0.119641962954605 4333 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3162 9099653 49.47 µM -1.17786840990052 0.155133205568668 no 2847 0.119424535343371 4234 25237511 SGTC_249 wiskostatin 11.211 µM -1.17829333615082 0.155035379921338 no 2848 0.119339841761565 4251 2775510 A n-wasp and actin depolymerizer. SGTC_3288 9119690 36.221 µM -1.18028919360328 0.154576442824302 no 2849 0.11894260732542 4255 17595618 YKL019W RAM2 SGTC_3078 9116413 49.47 µM -1.18096771841938 0.154420624275612 no 2850 0.118807773816197 4193 17177322 SGTC_3062 9077494 49.47 µM -1.18108347245171 0.15439405253194 no 2851 0.118784782461388 4223 16459633 SGTC_2969 9091408 28.7 µM -1.18189065131199 0.154208845838526 no 2852 0.118624545950217 4226 4286311 SGTC_2534 helenine 20.12 µM -1.18214186636794 0.154151234692952 no 2853 0.118574707358469 4285 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_594 1487-1584 10.8 µM -1.18438272197158 0.153637969257594 no 2854 0.118130798281465 4220 5013332 SGTC_2529 gangaleoidin 93.61 µM -1.18550140206433 0.153382160784527 no 2855 0.117909630319133 4287 4565183 SGTC_48 0382-0018 55 µM -1.18645956999567 0.153163281069935 no 2856 0.117720429368328 4347 762596 SGTC_1685 st024049 53.0905 µM -1.18717682964621 0.152999568936672 no 2857 0.117578939138786 4285 1941139 SGTC_2894 9048625 32.47 µM -1.19019476109008 0.152312007446645 no 2858 0.11698492591179 4295 4092861 SGTC_381 3461-2219 42.7 µM -1.19208276686684 0.151882916283533 no 2859 0.116614396747416 4277 2883159 SGTC_2852 9023854 51.95 µM -1.19212814936061 0.151872611999832 no 2860 0.116605500494334 4310 19798528 SGTC_1181 1222-0449 220 µM -1.19298039962109 0.151679191298104 no 2861 0.116438524701733 4340 658318 SGTC_2480 5767542 37.17 µM -1.19327510258906 0.151612345705335 no 2862 0.116380824970589 4209 2867358 SGTC_2656 pseudo-anisatin 100 µM -1.19339275472478 0.151585664892584 no 2863 0.116357795590347 4325 6708809 A neurotoxin. SGTC_715 0868-0130 184 µM -1.19657103939866 0.150866083678708 no 2864 0.115736897042682 4330 2876258 SGTC_2725 haloperidol 53.21 µM -1.1986128308926 0.150405012328998 no 2865 0.115339263352351 4219 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1184 1269-1718 139 µM -1.20041052092249 0.149999841234125 no 2866 0.114989972417702 4326 5403821 SGTC_1749 st037932 54.2 µM -1.20319741037212 0.149373160038108 no 2867 0.114449968397191 4323 594497 SGTC_3284 9108171 64.8615 µM -1.20701085292983 0.148518476318684 no 2868 0.113713982192158 4276 8687505 SGTC_2853 9015042 58.44 µM -1.20923082305842 0.148022436723275 no 2869 0.113287089531793 4213 6457456 SGTC_154 3389-1638 511.116 µM -1.20984317562549 0.147885805395231 no 2870 0.113169537647536 4294 5238686 SGTC_505 gw-5074 63.9 µM -1.2101730018377 0.147812247831601 no 2871 0.113106257758648 4317 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_178 4092-0806 87.505 µM -1.21045899586122 0.147748485519593 no 2872 0.113051407880034 4184 2169044 SGTC_650 1328-0195 38 µM -1.21099814399796 0.147628332645032 no 2873 0.112948058012251 4293 2780821 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.21164827746991 0.147483532990721 no 2874 0.112823522962814 4329 5393153 SGTC_1964 st076914 61 µM -1.21540113161835 0.146649546595781 no 2875 0.112106568322379 4348 24208661 SGTC_131 0141-0277 33.849 µM -1.21632199720007 0.146445389676774 no 2876 0.111931142570143 4258 1547771 SGTC_1878 temozolomide 1 mM -1.21656650720683 0.146391213609276 no 2877 0.111884596182729 4221 5394 DNA alkylating agent. SGTC_861 0443-0273 110 µM -1.21664530652351 0.146373756916778 no 2878 0.111869598423189 4297 6149169 SGTC_164 4100-3994 89.624 µM -1.21788429014006 0.14609946422645 no 2879 0.111633973469562 4302 4615967 SGTC_1564 D-Arginine 115 µM -1.21850227072768 0.145962781586036 no 2880 0.111516581196785 4316 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_700 3453-2283 142 µM -1.22129562022613 0.145346031158909 no 2881 0.110987055550522 4352 565664 SGTC_635 k038-0028 24.7 µM -1.22251113054777 0.145078203872354 no 2882 0.1107571986708 4308 4035102 SGTC_697 0508-1955 564 µM -1.22526571962426 0.144472483771144 no 2883 0.110237559982123 4301 6243113 SGTC_639 0833-0042 114 µM -1.22564824676981 0.144388502950695 no 2884 0.110165536753947 4316 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_404 fumagillin 50 µM -1.22795943608193 0.143881799515017 no 2885 0.109731097872247 4314 12015870 A methionine aminopeptidase binder. SGTC_2085 5307070 144.047 µM -1.22981246833777 0.14347640951289 no 2886 0.109383669044596 4245 2840351 SGTC_1209 2323-2347 50.3 µM -1.2312632522573 0.143159558526573 no 2887 0.109112210585484 4315 5412760 SGTC_1237 0330-0133 46.1 µM -1.23164818225561 0.14307556927675 no 2888 0.109040267065005 4244 X1237 YHR072W ERG7 SGTC_3348 9149464 3.537 µM -1.23303165798326 0.142773978652829 no 2889 0.108781976564172 4250 1951442 SGTC_479 n-linoleoylglycine 10 µM -1.23414016169567 0.142532640848292 no 2890 0.108575340154648 4358 6433346 An anti-infammatory. SGTC_2803 7707263 71.43 µM -1.2372695544879 0.141852814841985 no 2891 0.107993513416701 4289 2199229 SGTC_1621 st003705 32.4 µM -1.23772150289086 0.14175481579757 no 2892 0.107909671599068 4326 24207032 SGTC_2368 9071271 200 µM -1.23823529998224 0.141643461390009 no 2893 0.107814413062276 4304 27209959 SGTC_637 1181-0519 7.26 µM -1.24270218871302 0.140677857059091 no 2894 0.106988798548915 4318 6252091 YGR060W ERG25 SGTC_2092 5303694 80.6725 µM -1.24475128518869 0.14023640341054 no 2895 0.106611593967792 4319 1963699 SGTC_669 0108-0021 26.2 µM -1.2507529718387 0.138948829142138 no 2896 0.105512308764334 4339 17201 SGTC_833 3852-0053 558 µM -1.25098491163518 0.138899231907215 no 2897 0.10546999117795 4380 3123681 SGTC_1202 1988-0068 29.6 µM -1.25147950761819 0.138793509411267 no 2898 0.105379792778295 4298 2850480 SGTC_2639 lactacystin 53 µM -1.25194484019021 0.13869409217202 no 2899 0.105294982041551 4354 3870 A proteasome inhibitor. SGTC_1856 st057054 55.7 µM -1.25418513608364 0.138216137109019 no 2900 0.104887360607812 4333 1266018 SGTC_1008 4106-0037 6 µM -1.25467891063909 0.138110944176081 no 2901 0.104797672276981 4337 2905394 SGTC_1079 idarubicin 2.36 µM -1.25476335380544 0.138092960008457 no 2902 0.10478233973299 4339 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_271 rotenone 740 µM -1.25810605129643 0.137382336240021 no 2903 0.104176702581186 4369 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2404 5161160 200 µM -1.25859749661723 0.137278070846556 no 2904 0.104087875856099 4279 2831543 SGTC_213 1246-0773 967 nM -1.26325121098189 0.136293414444572 no 2905 0.103249456958027 4357 6251622 SGTC_726 3448-4391 34.2 µM -1.26435377310635 0.136060838615793 no 2906 0.103051538507062 4434 1356692 SGTC_330 1488-0319 80.1 µM -1.26441382279324 0.136048179465649 no 2907 0.103040767040995 4378 6846614 SGTC_1062 mesoridazine 14.2 µM -1.26504665515095 0.135914820298112 no 2908 0.102927301891433 4375 4078 A neuroleptic. SGTC_1709 st033179 39.1045 µM -1.27057399114202 0.134753828822495 no 2909 0.101940122306637 4336 573381 SGTC_597 k018-0003 82.8 µM -1.27073843642414 0.134719392404273 no 2910 0.101910858375337 4413 6786234 SGTC_1785 bathophenanthroline 24 µM -1.27219786640522 0.134414038395864 no 2911 0.101651412759946 4263 72812 An iron chelator. SGTC_2910 7948405 25.97 µM -1.27630007653429 0.133558286563549 no 2912 0.100924731574563 4292 2971328 SGTC_1157 4092-0394 27.6 µM -1.27715156255877 0.133381130778083 no 2913 0.100774371913605 4409 3659885 SGTC_3194 9111903 49.47 µM -1.27834813306442 0.133132451797054 no 2914 0.100563351684812 4368 17087251 SGTC_1824 st053723 68.6 µM -1.28359250168623 0.132046298534369 no 2915 0.0996422873742899 4364 675225 SGTC_787 4152-0075 138 µM -1.28362548274202 0.132039487269897 no 2916 0.0996365145076569 4364 9566539 SGTC_591 4299-0174 154 µM -1.28763116733205 0.131214032494238 no 2917 0.0989371923029784 4384 5509088 SGTC_1603 st002045 67.8 µM -1.2891437190076 0.13090326866001 no 2918 0.0986740634670133 4359 5887985 SGTC_2885 9057732 51.95 µM -1.28957021530791 0.130815734151592 no 2919 0.0985999613227153 4393 6471414 SGTC_2136 5328288 199.296 µM -1.29295495943426 0.130122480575998 no 2920 0.098013318683504 4348 262395 SGTC_399 oxolinic acid 75 µM -1.29442221912317 0.129822752022978 no 2921 0.0977598099619291 4332 4628 A DNA gyrase inhibitor. SGTC_2654 protoveratrine a 100 µM -1.29598389608272 0.12950426167227 no 2922 0.0974905165455447 4377 5702278 A heart drug and vasodilator. SGTC_1788 fluconazole 20 µM -1.29721147221864 0.129254288562262 no 2923 0.0972792172448179 4375 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1907 st060210 83.7 µM -1.29950937324122 0.128787263071399 no 2924 0.0968845894179106 4372 688793 SGTC_3115 9123671 49.47 µM -1.30421036505724 0.127835483804267 no 2925 0.0960809334015561 4511 3286988 SGTC_2126 5251174 33.877 µM -1.3061663176575 0.127440918397153 no 2926 0.0957480021912314 4362 790722 SGTC_2040 5100729 123 µM -1.30954507309658 0.126761334192743 no 2927 0.095174890138464 4394 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_351 caspofungin 25 nM -1.31102487489286 0.126464491035485 no 2928 0.0949246798765542 4368 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2149 5554786 194.827 µM -1.31111918340057 0.126445589501549 no 2929 0.0949087502936674 4409 745063 YPR165W RHO1 SGTC_844 0330-0132 15.3 µM -1.31157494503698 0.126354272417054 no 2930 0.094831795676759 4433 2828079 SGTC_2380 9035439 200 µM -1.31185469143598 0.126298244774089 no 2931 0.0947845837256569 4441 6462575 SGTC_3352 9151559 45.5865 µM -1.31447167796579 0.125774952875805 no 2932 0.0943437615104644 4389 17159339 SGTC_1616 st002734 56.1 µM -1.31464971780403 0.125739407105645 no 2933 0.0943138263450812 4330 4026101 SGTC_1637 st007924 17.4 µM -1.31474312163405 0.125720761772748 no 2934 0.0942981244646159 4291 683336 SGTC_528 3492-0019 172 µM -1.31842489860524 0.124987339104848 no 2935 0.0936807251880055 4382 2869262 SGTC_1420 4'-methoxyflavone 42 µM -1.32246824357287 0.124185340255639 no 2936 0.0930061386341289 4362 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_265 mycophenolic acid 32.932 µM -1.32334444221185 0.124012021605234 no 2937 0.0928604293085039 4431 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_545 4218-0007 221 µM -1.32464161405797 0.123755742216098 no 2938 0.092645023351275 4371 2840508 SGTC_1470 k295-0292 231 µM -1.32544539565937 0.12359712703626 no 2939 0.0925117344537298 4455 5045612 SGTC_2519 cryptotanshinone 88.04 µM -1.32565467763277 0.123555851504069 no 2940 0.0924770530885545 4372 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1134 3477-0009 42.5 µM -1.3260015233361 0.123487466293513 no 2941 0.0924195964002755 4439 3973534 SGTC_1568 digitonin 820 nM -1.32886863699627 0.122923192243965 no 2942 0.091945656324553 4355 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2328 6201408 200 µM -1.32906624871159 0.122884367165845 no 2943 0.0919130571063174 4368 2890418 SGTC_208 k072-0098 12.366 µM -1.32982760207366 0.12273486328467 no 2944 0.0917875396917027 4367 5948901 SGTC_2357 9067248 200 µM -1.33103095207765 0.122498826561674 no 2945 0.0915894133138824 4343 9150235 SGTC_2976 9009005 19.48 µM -1.33111122934637 0.122483091541743 no 2946 0.0915762072931176 4396 2993148 SGTC_2193 5925765 200 µM -1.33119851278645 0.122465984862696 no 2947 0.0915618503225712 4396 877370 SGTC_2211 7117706 200 µM -1.33426172877656 0.121866686891037 no 2948 0.0910590477450419 4325 822771 SGTC_573 3702-0553 84.7 µM -1.3356729298235 0.121591289039125 no 2949 0.0908281005541159 4335 1222756 SGTC_1093 fluphenazine 7.97 µM -1.33961954188007 0.120823425335722 no 2950 0.0901845336211554 4433 6602611 An atypical antipsychotic. SGTC_398 bronopol 33.3 µM -1.3445571386211 0.119867567353706 no 2951 0.089384146328536 4322 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_612 0302-0167 22.4 µM -1.35209745979106 0.118418162598952 no 2952 0.088172069920837 4413 235821 SGTC_1344 1488-0097 29.1 µM -1.35423341793699 0.118009848508123 no 2953 0.0878309603057155 4438 747966 SGTC_874 0599-0792 117 µM -1.35589215036353 0.117693449577551 no 2954 0.0875667427127753 4395 765305 SGTC_3219 9131112 49.47 µM -1.35774710165089 0.117340334087882 no 2955 0.0872719726650548 4275 17612988 YMR079W SEC14 SGTC_2770 toltrazuril 17.5 µM -1.35776119286375 0.117337654506385 no 2956 0.0872697362711474 4346 68591 Kills coccidiodes. SGTC_1754 st042065 16.137 µM -1.35791205407099 0.117308969492669 no 2957 0.0872457960107691 4171 1126236 YIL048W NEO1 SGTC_1385 3091-4834 14.1 µM -1.36216723913717 0.11650192607886 no 2958 0.086572556116265 4397 4072814 SGTC_1881 5652484 16 µM -1.36552037638681 0.115868746253078 no 2959 0.0860447766163151 4396 2255129 SGTC_1187 1391-0724 117 µM -1.3672453673911 0.115543966210822 no 2960 0.0857742047851747 4467 6997986 SGTC_1066 ketoconazole 628 nM -1.36793894442082 0.115413562519505 no 2961 0.0856655941166844 4472 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1706 st031321 9.9705 µM -1.36941302120566 0.115136759702424 no 2962 0.0854351031348918 4437 6103185 SGTC_2159 5658611 73.75 µM -1.37729777779546 0.1136641707969 no 2963 0.0842101010016959 4400 793844 SGTC_2325 6158266 200 µM -1.37803243312956 0.113527650505326 no 2964 0.0840966373686806 4411 3623240 SGTC_2718 lomofungin 53.02 µM -1.37825281178404 0.11348672055896 no 2965 0.0840626234386227 4400 5351222 A RNA synthesis inhibitor. SGTC_3038 9091290 49.47 µM -1.38091255194429 0.112993568563557 no 2966 0.0836529250473801 4427 25236843 SGTC_312 4092-0653 6.84 µM -1.38484316533634 0.112267582732991 no 2967 0.0830502143917022 4326 1148278 SGTC_1215 3852-0577 11.2 µM -1.38657335454991 0.111949074943158 no 2968 0.0827859489803236 4452 2884876 SGTC_983 1491-0821 12.2 µM -1.3934030948529 0.110698109078174 no 2969 0.0817489651921025 4415 46495113 SGTC_569 4130-2812 160 µM -1.39378832574916 0.110627848117254 no 2970 0.0816907672581044 4293 743552 SGTC_821 1114-0266 29.2 µM -1.40257906874237 0.109033212602082 no 2971 0.0803711985444886 4465 3123235 SGTC_3153 9100258 49.47 µM -1.40419083744157 0.108742639994909 no 2972 0.0801310147755206 4363 25236848 SGTC_3291 9121177 71.43 µM -1.40626101824862 0.108370241527092 no 2973 0.07982331550378 4424 17015612 SGTC_1011 4112-3381 17.4 µM -1.40704217975182 0.108229959528012 no 2974 0.0797074408483873 4479 2877139 SGTC_3255 9139072 49.47 µM -1.4117976003291 0.107378794074596 no 2975 0.0790047826258781 4434 17646060 SGTC_327 1273-0057 3.96 µM -1.41440318434192 0.106914475930861 no 2976 0.0786217778312875 4346 3108138 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.41620337960721 0.106594526205277 no 2977 0.0783579833471055 4469 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_828 2074-0507 139 µM -1.4181817051655 0.106243715032542 no 2978 0.0780688608775549 4496 X828 SGTC_2165 5727197 32.143 µM -1.4190217159001 0.106095010666017 no 2979 0.0779463425341269 4503 1361712 SGTC_248 streptozotocin 5.23457 mM -1.42003265720309 0.105916246472158 no 2980 0.0777990869194107 4477 5300 DNA alkylating agent. SGTC_858 0438-0351 2.77 µM -1.42059287262018 0.105817277676539 no 2981 0.0777175758617262 4425 2799119 SGTC_687 k029-0044 34.9 µM -1.42326717025646 0.105345751953256 no 2982 0.0773293600746245 4512 5829338 SGTC_2440 5628896 157.78 µM -1.42549076288894 0.104954852299918 no 2983 0.0770076941749313 4417 5522048 SGTC_2449 5812982 45.77 µM -1.42859527217081 0.104410848642871 no 2984 0.0765602969095966 4381 776185 SGTC_2825 7998094 58.44 µM -1.43225749564902 0.103771746907799 no 2985 0.0760350712588746 4426 2987815 SGTC_2772 vinpocetine 57.06 µM -1.43252009703432 0.103726029109304 no 2986 0.0759975153819585 4459 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2998 9066762 71.4286 µM -1.43677488646097 0.102987323550006 no 2987 0.0753909842221203 4476 4945196 SGTC_1774 st048371 48.465 µM -1.43737521627862 0.102883404254553 no 2988 0.0753057035082372 4455 4242727 SGTC_2974 9094440 9.66 µM -1.43768832479229 0.102829234261349 no 2989 0.0752612536178933 4449 25236134 SGTC_467 ro 31-8220 72.8 µM -1.43938400080682 0.1025362302934 no 2990 0.0750208774126266 4411 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_284 0988-0104 32.6 µM -1.44501038668296 0.101568369142423 no 2991 0.07422748408903 4428 4666532 SGTC_3141 9094609 49.47 µM -1.44622440204778 0.101360407502499 no 2992 0.0740571357598041 4434 25236309 YDL196W YDL196W SGTC_1811 st050069 61.5 µM -1.44828834879703 0.101007564321018 no 2993 0.0737682123949418 4455 3877702 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.44953932334701 0.100794139528906 no 2994 0.073593513471846 4458 75037 A free radical scavenger. SGTC_1873 rapamycin 2 nM -1.45033266626923 0.100658960327641 no 2995 0.0734828869493465 4421 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_3005 9076496 71.4286 µM -1.45373665582063 0.100080448944463 no 2996 0.0730096656730529 4442 21368410 SGTC_2764 methyldopa 94.69 µM -1.45441974611047 0.0999646501131052 no 2997 0.0729149843434199 4432 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2551 apiole 73.87 µM -1.45575702821034 0.0997382347178291 no 2998 0.0727298993779725 4404 10659 A possible DNA adduct former. SGTC_1471 k673-0312 37 µM -1.45599256412951 0.0996983949382196 no 2999 0.0726973375987795 4450 24099884 SGTC_2110 5483698 200 µM -1.4594745105079 0.0991107961216696 no 3000 0.0722172756177364 4458 2848765 YHR062C RPP1 SGTC_509 pifithrin 175 µM -1.46570987279542 0.0980648785834601 no 3001 0.0713636716787078 4548 4817 A p53 inhibitor. SGTC_3016 9080866 49.47 µM -1.46641021715494 0.0979479101488921 no 3002 0.0712682822636711 4448 17066299 SGTC_1142 3253-1408 9.78 µM -1.46704754412048 0.0978415554907654 no 3003 0.0711815611399877 4486 256655 SGTC_1233 0325-0408 14.2 µM -1.46810839647338 0.0976647123122799 no 3004 0.0710373905945737 4513 12874 SGTC_753 1322-0200 289 µM -1.46945019826397 0.0974413709310937 no 3005 0.0708553601681928 4525 5403907 SGTC_762 1165-0429 115 µM -1.4694954425332 0.0974338466084658 no 3006 0.0708492285279084 4470 5967793 SGTC_1934 st074720 32.6 µM -1.47026559997307 0.0973058313764765 no 3007 0.0707449169790266 4414 17250992 SGTC_2830 7992007 71.43 µM -1.47046710090855 0.0972723583551753 no 3008 0.0707176448056953 4367 1952075 SGTC_556 4058-0063 51.5 µM -1.47615767865236 0.0963305338949435 no 3009 0.0699507839232885 4516 6615692 SGTC_3146 9095609 49.47 µM -1.47673500803393 0.0962353581989464 no 3010 0.0698733420574741 4520 17173999 SGTC_2243 6634756 200 µM -1.47714143424453 0.0961683982322319 no 3011 0.0698188644029331 4514 885676 SGTC_1556 plumbagin 1.48 µM -1.47999424026718 0.0956993534042598 no 3012 0.0694373918883072 4415 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2880 9042983 58.44 µM -1.48057589120534 0.095603928035165 no 3013 0.0693598118581405 4432 6464714 SGTC_1900 st060200 72.8 µM -1.48634960305403 0.0946604903609522 no 3014 0.0685933363634205 4474 688945 SGTC_2566 crystal violet carbinol 226 nM -1.48811823771223 0.0943728689621732 no 3015 0.0683598573006552 4447 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2816 7982706 58.44 µM -1.49323691555524 0.0935440844767523 no 3016 0.0676875910736926 4479 2981853 SGTC_513 4245-1575 41.7 µM -1.4959803930649 0.0931020962297014 no 3017 0.0673293823305933 4323 719745 SGTC_2826 7992541 19.48 µM -1.49700720302235 0.0929370694525166 no 3018 0.0671956919112116 4492 2985066 SGTC_1816 st051957 91.6 µM -1.50348620604244 0.0919007619943448 no 3019 0.0663568556820393 4501 674121 SGTC_1196 1588-0294 184 µM -1.50855375539512 0.0910961981560942 no 3020 0.0657064298010678 4530 6144269 SGTC_1392 3455-1037 33.9 µM -1.5094363270807 0.0909566099340909 no 3021 0.0655936577531022 4495 981132 SGTC_1133 3473-0247 50 µM -1.5102847851861 0.0908225667954587 no 3022 0.0654853861661845 4465 711311 SGTC_757 1066-0008 322 µM -1.51371776224435 0.090281706190074 no 3023 0.0650487189948612 4525 6842497 SGTC_576 1073-0113 22.7 µM -1.51521153542519 0.0900471127049395 no 3024 0.0648594213655105 4575 5439563 SGTC_662 k832-1615 104 µM -1.5155755619509 0.0899900119126816 no 3025 0.0648133551693946 4518 5878478 SGTC_452 diindolylmethane 8 µM -1.51746036817289 0.0896947935781163 no 3026 0.0645752461616347 4501 3071 Inhibits expression of several cancer promoting factors. SGTC_1821 st053465 65.6 µM -1.51826750985217 0.0895685909162925 no 3027 0.064473487367513 4528 675086 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.52212160853959 0.0889677938615948 no 3028 0.0639893062800335 4511 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2988 9073640 71.4286 µM -1.52503180114281 0.0885161294307836 no 3029 0.0636255829523148 4518 9102229 SGTC_70 0141-0289 43.283 µM -1.52601252544718 0.0883643056438079 no 3030 0.0635033725743241 4461 352408 SGTC_2001 4023502 57.655 µM -1.52829806022145 0.0880112402078186 no 3031 0.0632192756606274 4508 108941 YCR052W RSC6 SGTC_1425 4048-4433 7.33 µM -1.52957446576229 0.0878145216147117 no 3032 0.0630610469147359 4576 23734946 SGTC_931 2812-0076 566 µM -1.52985351894003 0.0877715578862638 no 3033 0.0630264954001479 4438 3450959 SGTC_2812 7970281 58.44 µM -1.53077629592006 0.0876295964803403 no 3034 0.0629123449591085 4529 2233435 SGTC_2179 6298986 200 µM -1.53080367108245 0.0876253876620793 no 3035 0.0629089610262516 4470 738374 SGTC_2745 rifampicin 24.3 µM -1.53163994836384 0.087496886153861 no 3036 0.0628056543891201 4609 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2168 5727979 200 µM -1.53223427546847 0.0874056479883733 no 3037 0.0627323166248166 4420 695210 SGTC_356 1634-0012 32.5 µM -1.5324757919746 0.0873685918651786 no 3038 0.062702533459415 4509 735457 SGTC_2793 7325131 81.82 µM -1.53539259586156 0.0869219893374474 no 3039 0.062343710675926 4471 4176441 SGTC_313 3474-0040 5.03 µM -1.53555452162554 0.0868972463500603 no 3040 0.0623238377176574 4533 1043375 YIL048W NEO1 SGTC_2942 9052777 62.25 µM -1.53658623717778 0.0867397191172132 no 3041 0.0621973324811996 4513 6469503 SGTC_3036 9090181 49.47 µM -1.5382783632879 0.0864818194328193 no 3042 0.0619902838578389 4578 25236586 SGTC_36 0335-0881 14.2 µM -1.54195675369919 0.0859231683158033 no 3043 0.0615420515059732 4408 23828853 SGTC_1219 1469-0211 33.1 µM -1.54370531670609 0.0856585563421629 no 3044 0.0613298688620447 4514 6822282 SGTC_856 0433-0016 11.3 µM -1.54482562187495 0.0854893402902038 no 3045 0.0611942240194056 4540 3911780 SGTC_1510 1123-0200 71.5 µM -1.54901935041202 0.0848581225518904 no 3046 0.0606885342479514 4523 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2792 7535235 81.82 µM -1.55001376994409 0.0847089616148484 no 3047 0.0605691055024647 4489 1281891 SGTC_895 0964-0006 13.7 µM -1.55273318495519 0.084302058973842 no 3048 0.0602434454238584 4522 6738897 SGTC_2955 9076254 12.21 µM -1.55389734456389 0.0841283163017679 no 3049 0.0601044526242417 4448 16459619 SGTC_2841 9004761 38.96 µM -1.56066815326976 0.0831231449762555 no 3050 0.0593010345474097 4466 2991039 SGTC_2687 chenodiol 100 µM -1.56141882627451 0.0830122611361754 no 3051 0.0592124813691464 4558 5702181 A cholesterol synthesis inhibitor. SGTC_1059 3448-6867 171 µM -1.56184653765752 0.0829491325612074 no 3052 0.0591620727694 4488 3934407 SGTC_2152 5568786 200 µM -1.5657679584507 0.082372028161539 no 3053 0.0587014749962098 4555 5399883 SGTC_1838 st055369 84.5 µM -1.56596781112027 0.0823426975811895 no 3054 0.0586780765224607 4506 676036 SGTC_2741 miltefosine 3.04 µM -1.56626255762354 0.0822994546388999 no 3055 0.0586435813714868 4571 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3294 9122953 26.2835 µM -1.56658367382825 0.0822523624045071 no 3056 0.0586060182089513 4513 16459826 SGTC_1084 voriconazole 435 nM -1.56717074271694 0.0821663202307792 no 3057 0.0585373935750565 4553 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1936 st074407 74.3 µM -1.56808256634833 0.082032815704008 no 3058 0.0584309322857885 4555 809813 SGTC_898 1000-0849 28.3 µM -1.56874650596689 0.081935707953478 no 3059 0.0583535087647018 4532 6751807 SGTC_489 paxilline 115 µM -1.5708977808532 0.0816216577110534 no 3060 0.0581031970790431 4490 105008 A toxic potassium channel blocker. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.5766157021303 0.0807913492076315 no 3061 0.0574419887630363 4535 6708561 SGTC_2495 cafestol 54.53 µM -1.57939136990789 0.080390596640861 no 3062 0.0571231578200247 4519 16667697 An anti-infammatory. SGTC_3097 9117246 49.47 µM -1.582470175521 0.0799478358778287 no 3063 0.0567711378110273 4561 16423892 SGTC_970 1315-0089 19.5 µM -1.58251315405564 0.0799416682428393 no 3064 0.0567662359137533 4522 6811083 YLR033W RSC58 SGTC_1056 3448-1962 115 µM -1.58267494890632 0.0799184530980307 no 3065 0.0567477854652105 4495 715507 SGTC_1548 st061468 90.8 µM -1.58427236666356 0.0796895210806613 no 3066 0.0565658756729332 4584 390799 SGTC_941 3237-0776 460 µM -1.58576355027875 0.0794762619216057 no 3067 0.056396478499085 4545 760008 SGTC_695 3505-6186 243 µM -1.58735887207946 0.0792485881116627 no 3068 0.056215694283661 4531 1819379 SGTC_2086 5274770 176.623 µM -1.59076271540313 0.0787644652250511 no 3069 0.0558314933957257 4571 689278 SGTC_1025 k007-0731 70 µM -1.59507467920349 0.0781544034857058 no 3070 0.0553477684809807 4529 6256118 SGTC_2905 7799065 20.05 µM -1.60188061268326 0.077198794644321 no 3071 0.0545910062144988 4435 1296806 SGTC_819 1013-0258 27.7 µM -1.60943395945249 0.076148665288639 no 3072 0.0537607423304059 4557 5753198 SGTC_734 2023-0417 80 µM -1.61003704936629 0.0760652897363197 no 3073 0.0536948841538284 4555 3935732 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.61343625070904 0.0755966585475834 no 3074 0.0533248813789542 4571 5357218 A potent inhibitor of glutathione S-transferases. SGTC_919 tnp00227 403.569 nM -1.61679988282446 0.0751350996916381 no 3075 0.0529607423668313 4519 1269246 A methoxyflavone. YNL221C POP1 SGTC_550 4123-0385 25.7 µM -1.61714295039422 0.0750881448550039 no 3076 0.0529237137656921 4575 5731123 SGTC_2962 9082311 13.18 µM -1.62029000353801 0.0746584588296041 no 3077 0.0525849976285445 4528 16459453 SGTC_3177 9107506 49.47 µM -1.62368287774099 0.0741973141863203 no 3078 0.0522217535754762 4534 8897194 SGTC_3098 9119039 49.47 µM -1.62511591913398 0.074003196205411 no 3079 0.052068930754556 4542 17161528 SGTC_63 0099-0242 26.702 µM -1.63018358129365 0.0733198484959944 no 3080 0.0515313514703475 4571 3898502 YLR359W ADE13 SGTC_1377 2944-0135 198 µM -1.63690076904185 0.0724215233037092 no 3081 0.0508256026182867 4568 1894137 SGTC_1970 st070122 35.8 µM -1.63785368481668 0.0722947707409364 no 3082 0.0507261097506517 4583 102928 SGTC_216 k038-0035 28.382 µM -1.64195508944592 0.0717511601261008 no 3083 0.0502996558652077 4510 4444231 YPR107C YTH1 SGTC_1324 1418-0026 34.4 µM -1.64253649848418 0.0716743530973564 no 3084 0.0502394343068485 4584 1372513 SGTC_2670 beta-carotene 100 µM -1.6434248548971 0.0715571186257959 no 3085 0.0501475305600369 4557 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1509 1326-1131 80 µM -1.64415607600934 0.0714607314035068 no 3086 0.0500719836452874 4548 768313 SGTC_1362 1611-0397 101 µM -1.6519816675137 0.0704354169895377 no 3087 0.0492691440422135 4566 27816 SGTC_215 1287-0124 461.5 µM -1.65345213542628 0.070244023811135 no 3088 0.0491194398969382 4610 5560863 SGTC_1842 st055362 61.2 µM -1.6544822723973 0.0701101816547652 no 3089 0.0490147811695183 4536 676032 SGTC_1932 st074806 40.9 µM -1.66071645962909 0.0693043773661055 no 3090 0.0483852030386011 4593 17251235 SGTC_967 1306-0166 352 µM -1.66326495962345 0.0689770309868052 no 3091 0.0481297047754423 4569 4437607 SGTC_1331 1472-0049 76.2 µM -1.66523728698208 0.0687245111369432 no 3092 0.0479327123304552 4553 24051409 SGTC_1600 coumarin 106 71.1 µM -1.67208586874827 0.0678532103539354 no 3093 0.0472536953795548 4624 100336 A hepatotoxic, DNA x-linker. SGTC_586 0957-0265 8.15 µM -1.67290833047369 0.0677491502327686 no 3094 0.0471726718022257 4498 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_158 k038-0087 26.446 µM -1.67563092153808 0.0674055598258212 no 3095 0.0469052540805524 4489 X158 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.68069001278401 0.0667706819927263 no 3096 0.0464115707514721 4558 5282362 SGTC_1710 st031758 61.5 µM -1.68570856713823 0.0661454725785555 no 3097 0.045925972975569 4620 5394341 SGTC_592 k241-0073 46.5 µM -1.68779239660738 0.0658872062560944 no 3098 0.0457255438336313 4619 4230158 SGTC_359 0081-0058 15.9 µM -1.69058821858042 0.0655419252557663 no 3099 0.0454577381779467 4568 3494159 SGTC_1430 4049-0248 69.1 µM -1.69893643662671 0.0645192764672813 no 3100 0.0446655803756078 4610 22774488 SGTC_993 3909-8757 62.7 µM -1.70138690658541 0.0642214615981969 no 3101 0.0444351791634221 4553 4288324 YLR208W SEC13 SGTC_3136 9095672 49.47 µM -1.70723227033517 0.0635153671573834 no 3102 0.0438894446074131 4460 17217380 SGTC_1113 artemisinin 1.17947 µM -1.70808453132203 0.0634129243467165 no 3103 0.0438103293518568 4615 2240 An anti-malaria and mitochondrial poison. SGTC_2491 paeonol 100 µM -1.71597131265144 0.0624710155611337 no 3104 0.0430836465609249 4583 11092 Increases levels of cortical cytochrome oxidase. SGTC_236 1509-0011 5.31 µM -1.72080345827504 0.0618993297269353 no 3105 0.04264324733818 4608 3107280 SGTC_439 amiodarone 34.4 µM -1.72296274694103 0.0616451902816967 no 3106 0.0424476310036205 4473 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_85 0868-0259 160.055 µM -1.7272453387875 0.0611435577653774 no 3107 0.0420618057043824 4548 83173 SGTC_2532 xanthone 78.9 µM -1.72818906980912 0.0610334459228218 no 3108 0.0419771663481387 4605 7020 An insecticide. SGTC_2659 sanguinarine 24.21 µM -1.72822797109072 0.0610289103608309 no 3109 0.041973680413079 4565 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1293 1000-1278 195 µM -1.72828500056532 0.0610222616803663 no 3110 0.0419685704383485 4616 678847 SGTC_1353 1498-1206 8.11 µM -1.72848428163024 0.0609990332956898 no 3111 0.0419507183418709 4615 6756808 SGTC_2617 dihydrotanshinone i 20.83 µM -1.72884454239897 0.0609570585112538 no 3112 0.041918460883634 4551 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3156 9099931 49.47 µM -1.73685685861225 0.0600293492734857 no 3113 0.0412062199726582 4639 18111053 SGTC_2113 5491891 107.031 µM -1.73728147827624 0.0599804947164316 no 3114 0.0411687495949146 4589 789979 SGTC_1432 4049-0298 68.4 µM -1.74097281584743 0.0595570992772716 no 3115 0.0408441718288953 4626 741646 SGTC_2456 5770359 74.46 µM -1.74190874871698 0.059450121136453 no 3116 0.0407622064216634 4573 3118787 SGTC_2848 9016370 25.97 µM -1.74257862777679 0.0593736457638248 no 3117 0.0407036229760518 4577 7894410 SGTC_3128 9127691 49.47 µM -1.74608620446295 0.0589744689401452 no 3118 0.0403979868083209 4600 41316314 SGTC_1978 st071761 42 µM -1.7489721138586 0.0586476218420381 no 3119 0.0401479199181224 4620 5147680 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.75054723993481 0.0584698298827548 no 3120 0.0400119650725279 4633 165506 SGTC_2220 6782180 200 µM -1.75232259001618 0.05826994534778 no 3121 0.0398591768923291 4574 833803 SGTC_2610 ononetin 44.17 µM -1.75554046889595 0.0579090168275294 no 3122 0.0395834524013488 4581 259632 SGTC_2457 5731572 11.68 µM -1.76011063411908 0.0573994341350686 no 3123 0.0391945250425265 4652 2865357 SGTC_145 3737-0113 38.366 µM -1.76334532671315 0.0570408964497829 no 3124 0.0389211324519605 4589 6849351 SGTC_151 3013-0144 2.285 µM -1.76541069441154 0.0568128921621754 no 3125 0.0387473836634178 4375 906558 YHR107C CDC12 SGTC_2251 lansoprazole 556 µM -1.76626366120587 0.0567189393992337 no 3126 0.0386758125405747 4597 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1813 st051246 8.6015 µM -1.77460102121835 0.0558070264844176 no 3127 0.037981894253702 4582 5291959 SGTC_1627 st003713 25.6 µM -1.77624690802848 0.0556283795928107 no 3128 0.037846114896482 4617 16195070 YER133W GLC7 SGTC_947 3447-0010 211 µM -1.77633533734453 0.0556187941410363 no 3129 0.0378388310438104 4574 748350 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.7765771275876 0.055592591516427 no 3130 0.0378189208135064 4667 368090 SGTC_2739 tacrine 100.86 µM -1.78614942021326 0.0545630561191383 no 3131 0.0370375340627532 4663 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1622 st003707 19.4 µM -1.79007367090402 0.0541453708694615 no 3132 0.0367210344138637 4628 10140899 SGTC_807 1315-0151 48 µM -1.79155225968787 0.0539886522878215 no 3133 0.0366023581259355 4612 4011080 SGTC_1790 st045711 43.5 µM -1.79206005811258 0.0539349126311053 no 3134 0.0365616730474977 4605 585119 SGTC_146 3448-8650 53.125 µM -1.79983563234249 0.0531173114967921 no 3135 0.0359432978853137 4592 2891488 YIL048W NEO1 SGTC_73 0327-0325 16.231 µM -1.80202235658684 0.0528891567856182 no 3136 0.0357709441067698 4443 53298 SGTC_1427 4048-4900 550 nM -1.80501835426072 0.0525778283726469 no 3137 0.0355359049696267 4613 24132586 SGTC_2387 9077560 195.08 µM -1.80695528109122 0.0523773283962319 no 3138 0.0353846260147852 4617 5303272 SGTC_3340 9146634 11.102 µM -1.80900659860283 0.0521656497030309 no 3139 0.0352249891118887 4621 4907387 SGTC_2648 atorvastatin 78.68 µM -1.81014199800543 0.0520487785016186 no 3140 0.0351368847728508 4640 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2382 9035899 200 µM -1.81322069350171 0.0517329225988857 no 3141 0.0348988946993296 4621 6462679 SGTC_1950 st077106 7.18 µM -1.81447509354484 0.0516046662599407 no 3142 0.0348023069214243 4547 13831864 SGTC_624 k048-0052 28 µM -1.81512867761318 0.0515379406980106 no 3143 0.0347520685184524 4637 6835531 SGTC_1953 st076800 12.1 µM -1.8212423475175 0.0509171024798212 no 3144 0.0342850129272403 4594 297591 SGTC_2314 7727897 200 µM -1.82678268726097 0.0503596414983809 no 3145 0.0338662249736014 4609 900724 SGTC_3241 9133421 49.47 µM -1.82899446671925 0.0501384583743407 no 3146 0.0337002185848081 4713 17018221 SGTC_1887 st057648 70.8 µM -1.8346511840119 0.0495762957293403 no 3147 0.0332786948041591 4636 688672 SGTC_465 cgp-37157 41 µM -1.8469080975979 0.0483754665323848 no 3148 0.0323802304743064 4706 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2444 5485484 36.41 µM -1.85107652791974 0.047972420633297 no 3149 0.0320792721631692 4664 6790631 SGTC_2226 7298446 200 µM -1.85147128116269 0.0479343916421588 no 3150 0.0320508913076609 4656 3283010 SGTC_1061 3448-9325 110 µM -1.85250860124552 0.0478345752780415 no 3151 0.0319764117996341 4615 723482 SGTC_3061 glucosamine 200 µM -1.86214484283512 0.0469152588276901 no 3152 0.0312913383190948 4587 91431 and experimental redox chemotherapeutic SGTC_733 4069-0007 56.1 µM -1.86730735574418 0.0464286054434359 no 3153 0.0309293393938803 4648 5717425 YNL287W SEC21 SGTC_468 gf-109203x 121 µM -1.86832277802749 0.046333363448708 no 3154 0.0308585467667075 4713 2396 A protein kinase C inhibitor. SGTC_2522 biochanin a 4.94 µM -1.8702387330665 0.0461540828337053 no 3155 0.0307253366017154 4633 5280373 A possible chelator. SGTC_2477 5967686 25.23 µM -1.88090065400479 0.045166573971057 no 3156 0.0299927171244073 4632 776118 SGTC_2474 5321570 43.32 µM -1.88349339617314 0.0449290217692089 no 3157 0.0298167669763524 4660 2841384 SGTC_2999 9069765 71.4286 µM -1.88497612740403 0.0447936236745629 no 3158 0.0297165304683133 4620 2097066 SGTC_2432 5630864 12.22 µM -1.88574510868893 0.0447235323480431 no 3159 0.0296646555277919 4641 5714970 SGTC_1979 st071809 45.3 µM -1.90374416953482 0.0431080291015349 no 3160 0.028471755446342 4689 4976333 SGTC_1087 pterostilbene 9.05 µM -1.90603845611771 0.0429055362656302 no 3161 0.0283226082365323 4663 5281727 Similar to reservatol, lowers cholesterol. SGTC_1423 4048-0112 5.59 µM -1.90844512998315 0.0426939509259908 no 3162 0.0281668543035639 4698 X1423 SGTC_2549 cedrol 20.94 µM -1.91155873186248 0.0424214676740586 no 3163 0.0279664084117662 4639 6708665 A sedative which affects the nervous system. SGTC_1015 4130-4525 82 µM -1.91202421851867 0.0423808522808561 no 3164 0.027936543878462 4651 1363237 SGTC_1211 1056-0033 32.3 µM -1.91204161168909 0.0423793352737147 no 3165 0.02793542848842 4674 6741922 SGTC_49 0717-0965 32.132 µM -1.91376628762148 0.042229129517816 no 3166 0.0278250124407503 4697 5889349 YGL099W LSG1 SGTC_1150 3909-7983 10.9 µM -1.91520570630159 0.0421040974790021 no 3167 0.0277331375289719 4663 23965914 SGTC_678 1218-2179 85.9 µM -1.91568809407461 0.0420622629824881 no 3168 0.0277024043942976 4692 6820081 YOR116C RPO31 SGTC_393 acivicin 6.25 µM -1.92142759274972 0.0415670889253983 no 3169 0.0273389113382037 4543 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_585 0kpi-0023 191 µM -1.92364598768973 0.0413769673520473 no 3170 0.0271994862607 4621 64601 SGTC_3181 9108277 49.47 µM -1.92511808294234 0.0412511948430864 no 3171 0.0271072935923141 4653 17097298 SGTC_2030 5175110 200 µM -1.93060142229294 0.0407854353655895 no 3172 0.0267661809260917 4660 2831986 SGTC_2552 juarezic acid 87.02 µM -1.93062714822644 0.0407832602817295 no 3173 0.0267645890308595 4628 1549512 SGTC_3222 9128301 49.47 µM -1.93258125291649 0.0406183189576893 no 3174 0.026643901849984 4611 4911358 SGTC_1258 0671-0043 57.1 µM -1.93435758080888 0.0404688535318077 no 3175 0.026534589064496 4658 4298767 SGTC_2218 6965428 192.983 µM -1.93628962928127 0.0403067926130447 no 3176 0.0264161191230904 4590 675684 SGTC_2811 7967822 32.47 µM -1.93988974102806 0.0400062202152143 no 3177 0.0261965455621118 4655 2232244 SGTC_2475 5812728 15.03 µM -1.94186245469762 0.0398422928979187 no 3178 0.0260768768403788 4632 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2180 6301957 200 µM -1.94342731614093 0.0397126457378109 no 3179 0.0259822747342976 4686 845462 SGTC_2021 4019055 173 µM -1.94550805890985 0.0395407898401844 no 3180 0.0258569303674827 4449 44827708 YER133W GLC7 SGTC_1456 k015-0012 13 µM -1.95101247709708 0.0390890757285508 no 3181 0.0255277807815935 4663 2989616 SGTC_3104 9120930 49.47 µM -1.95264944342332 0.038955553226296 no 3182 0.0254305740719308 4677 17014836 SGTC_1029 k015-0030 64.7 µM -1.96219420012656 0.0381843938049822 no 3183 0.024869939465935 4675 2208316 SGTC_2384 9036245 200 µM -1.96666789191735 0.0378272555052316 no 3184 0.0246107554140488 4662 6462766 SGTC_1300 1094-0077 113 µM -1.96907579749776 0.037636161869761 no 3185 0.0244721938189086 4673 5532636 SGTC_538 2922-0838 53.3 µM -1.97110713232624 0.0374755667794656 no 3186 0.0243558115518271 4691 777039 SGTC_3292 9120825 59.784 µM -1.97312993870255 0.0373162024897746 no 3187 0.0242403800470582 4654 24824900 SGTC_2788 5282734 71.43 µM -1.9767785913943 0.0370301480321751 no 3188 0.0240333313216476 4672 743706 SGTC_1751 st044839 27.194 µM -1.97777396335186 0.0369524227905188 no 3189 0.0239771059930383 4699 5291326 SGTC_486 niguldipine 82 µM -1.98384686761448 0.0364810946369992 no 3190 0.0236364567824948 4736 1236 A calcium channel blocker. SGTC_3234 9132280 49.47 µM -1.98876638444611 0.0361028994470116 no 3191 0.0233634973922723 4685 17612295 SGTC_3054 9094397 49.47 µM -1.99681319204979 0.035491214346122 no 3192 0.0229227399821424 4649 2598354 SGTC_3215 9129942 49.47 µM -1.99991481248019 0.0352577222844269 no 3193 0.0227547316965328 4656 17682944 SGTC_1349 flufenamic acid 69 µM -2.00017931028249 0.035237869157824 no 3194 0.0227404525484933 4625 3371 A non-steroidal anti-inflammatory. SGTC_564 3555-0129 330 µM -2.0072477598283 0.0347107016010901 no 3195 0.0223616442712863 4646 563260 SGTC_1381 2324-0066 62.1 µM -2.00816362434644 0.0346428724961082 no 3196 0.0223129535274293 4687 10885928 SGTC_906 1165-0455 526 µM -2.0102743419831 0.0344869668187035 no 3197 0.022201080465803 4671 3252859 SGTC_778 3456-2434 196 µM -2.0177824155974 0.0339370573524388 no 3198 0.0218069635158394 4612 5539063 SGTC_777 1315-0167 517 µM -2.02736765416186 0.0332455130550191 no 3199 0.0213124136644905 4702 4221767 SGTC_1852 st056254 31.4 µM -2.02880631696089 0.0331427269308516 no 3200 0.021239010821029 4676 442583 SGTC_1833 st055984 71 µM -2.02908953096327 0.0331225234106143 no 3201 0.0212245860138933 4705 676288 SGTC_1195 1502-0147 41.1 µM -2.02949068530689 0.0330939237945188 no 3202 0.0212041683875082 4703 817940 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.0328076003526 0.0328582287623669 no 3203 0.0210359824890265 4687 803109 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -2.03585268839419 0.03264306927281 no 3204 0.0208825749238408 4709 5106787 A p450 inhibitor. SGTC_2525 harmine 47.85 µM -2.03657968698348 0.0325918732615262 no 3205 0.0208460900451742 4708 5280953 A monoamine oxidase inhibitor SGTC_116 0155-0182 31.788 µM -2.04028654682314 0.0323318609379436 no 3206 0.0206608969793406 4572 771486 SGTC_2029 5175081 200 µM -2.04535342682284 0.031979223261313 no 3207 0.0204100134927941 4659 1380876 SGTC_532 1548-0774 215 µM -2.04768937640952 0.0318177220499235 no 3208 0.0202952227284467 4719 5932993 SGTC_1428 4049-0204 61.7 µM -2.05215177255257 0.0315110770007853 no 3209 0.0200774573809651 4720 X1428 SGTC_3148 9097893 49.47 µM -2.05776349660482 0.0311289247570042 no 3210 0.0198064208737803 4659 17174100 SGTC_2075 5212009 200 µM -2.05974613052727 0.0309948294993352 no 3211 0.0197114084357603 4660 780898 SGTC_3293 9120939 62.045 µM -2.06229051102214 0.0308234412679472 no 3212 0.0195900429468374 4680 934087 SGTC_2434 5670830 169.91 µM -2.06775325429241 0.030458123051494 no 3213 0.0193316157000121 4698 1549830 SGTC_1814 st052110 31.539 µM -2.07745613837644 0.029818093114858 no 3214 0.018879739734419 4659 674163 SGTC_2671 danthron 100 µM -2.07850835259441 0.0297493615706672 no 3215 0.0188312811978883 4690 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3220 9131269 49.47 µM -2.08022585595877 0.0296374551787593 no 3216 0.0187524108702853 4711 17722206 SGTC_360 0957-0399 1.01 µM -2.08096246545948 0.0295895674892795 no 3217 0.0187186708926841 4698 6752301 YPR165W RHO1 SGTC_1815 st051655 58.2 µM -2.09862429469429 0.0284604485708843 no 3218 0.0179250164981828 4696 5984156 SGTC_2871 9038510 12.99 µM -2.10015463064287 0.0283643250321256 no 3219 0.0178576204552613 4674 4945164 SGTC_603 3794-0023 45.9 µM -2.10844391671017 0.0278483415242542 no 3220 0.0174963045391842 4727 3802260 SGTC_2303 7774051 200 µM -2.12159156026492 0.0270459912500117 no 3221 0.0169360258663154 4692 2953184 SGTC_1451 4152-0210 104 µM -2.12323496758269 0.0269470704683341 no 3222 0.0168670835728528 4720 659563 SGTC_725 1497-0963 19 µM -2.13028513099926 0.0265261241298206 no 3223 0.0165740401834354 4742 3549977 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.14066647442789 0.0259162938774418 no 3224 0.0161504719686036 4698 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2073 5212005 126 µM -2.1438456977112 0.0257318998642219 no 3225 0.0160226261999962 4684 691789 SGTC_2838 9002687 71.43 µM -2.14959831836012 0.025401040615582 no 3226 0.0157935007781263 4688 6457060 SGTC_2412 st077135 33.4 µM -2.17099281051413 0.024201655169633 no 3227 0.0149658579228322 4697 13258915 SGTC_217 ketoconazole 989 nM -2.18669850576134 0.0233517756220677 no 3228 0.0143822703863888 4569 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_24 0417-1663 219 µM -2.19772023212834 0.0227704741443405 no 3229 0.0139845244306345 4729 4329390 SGTC_3308 9128332 17.569 µM -2.20231607827153 0.0225317106143452 no 3230 0.0138214946207344 4701 17332805 YDL196W YDL196W SGTC_2947 9072639 7.68 µM -2.20796701695412 0.0222410297015468 no 3231 0.0136232862345831 4666 16488146 SGTC_688 0527-0193 473 µM -2.21938866864487 0.0216631598942741 no 3232 0.0132301469449313 4747 4007154 SGTC_876 0720-0963 56.8 µM -2.22654470853796 0.0213076091657576 no 3233 0.0129888588951652 4731 765861 SGTC_670 4204-0025 119 µM -2.22932491275821 0.021170810896034 no 3234 0.0128961471052889 4717 719039 SGTC_2342 7990637 118.86 µM -2.23122697322355 0.0210776497755718 no 3235 0.0128330490652467 4711 2033102 YER133W GLC7 SGTC_2798 7813637 45.45 µM -2.23615578709936 0.0208378537849324 no 3236 0.0126707841045618 4706 956368 SGTC_3211 9128781 49.47 µM -2.23634540684745 0.0208286747566246 no 3237 0.0126645771283959 4636 17194361 SGTC_607 4491-0986 66.8 µM -2.24886222485814 0.0202302912716257 no 3238 0.012260631497582 4721 698981 YDR232W HEM1 SGTC_2249 haloperidol 116.36 µM -2.25067112411037 0.0201450316095991 no 3239 0.0122031874857001 4669 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3080 9117754 49.47 µM -2.25199298354741 0.0200829206820031 no 3240 0.0121613577091548 4723 9550191 SGTC_372 0155-0182 15.9 µM -2.25893660616035 0.0197593181013226 no 3241 0.0119436642626047 4623 771486 SGTC_2492 derrusnin 100 µM -2.27014293678058 0.0192463937542092 no 3242 0.011599455958044 4754 1715307 Part of coumarin class of compounds. SGTC_2546 rhodinyl acetate 100 µM -2.27215294593547 0.0191556010082533 no 3243 0.0115386370798909 4718 6708682 SGTC_2759 disulfiram 3.38 µM -2.27299518636045 0.0191176651363174 no 3244 0.011513235010046 4667 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2618 avocadyne 43.43 µM -2.28404173505593 0.0186259944263398 no 3245 0.011184539140786 4703 3015189 SGTC_1817 st052116 64.4 µM -2.28651978082877 0.0185171895560967 no 3246 0.0111119341248427 4746 4361398 SGTC_1347 1493-0251 600 nM -2.28773217554304 0.0184641537675441 no 3247 0.011076561369833 4751 3986378 SGTC_1930 st074634 34.3 µM -2.28952980379792 0.0183857552697631 no 3248 0.01102429414111 4682 684253 YOR116C RPO31 SGTC_2982 9019404 25.97 µM -2.29164039924273 0.0182940696461757 no 3249 0.0109632011230239 4699 22333232 SGTC_2877 9040724 71.43 µM -2.30242949948344 0.0178314466189826 no 3250 0.0106554814872315 4708 6463895 SGTC_3197 9113331 49.47 µM -2.31230160571524 0.0174169231060023 no 3251 0.010380534134289 4709 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1318 1280-3875 124 µM -2.32505120351966 0.0168937747494771 no 3252 0.0100346112136641 4750 373245 SGTC_572 0960-0087 17.7 µM -2.33770688138462 0.016387827981789 no 3253 0.00970122947936656 4732 6796365 SGTC_506 n9-isopropylolomoucine 153 µM -2.34726803926105 0.0160142488180456 no 3254 0.00945582226674395 4741 6610355 SGTC_2279 7948423 32.93 µM -2.3624805309384 0.0154349072714397 no 3255 0.00907654745622105 4713 1247112 SGTC_3018 9082602 49.47 µM -2.36422233792472 0.0153697359934328 no 3256 0.00903398275089637 4640 17332089 SGTC_2219 9098279 200 µM -2.36571722331062 0.0153139920596779 no 3257 0.00899759159843735 4741 902349 SGTC_1718 roemerine 11.9335 µM -2.39527090979469 0.0142470636672316 no 3258 0.00830404456601008 4425 235224 An aporphine alkaloid with mutagenic activity. SGTC_951 1171-0579 82.7 µM -2.39856189720878 0.0141323140384908 no 3259 0.00822979719200709 4693 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2389 9091542 195.52 µM -2.40274309458484 0.0139876740576691 no 3260 0.00813630745445318 4725 3626624 YOL127W RPL25 SGTC_3267 9137951 49.47 µM -2.40950682606759 0.0137563982959031 no 3261 0.00798704861965981 4767 16643986 SGTC_326 k292-0812 17.5 µM -2.41554768273459 0.0135526362853368 no 3262 0.00785578258897702 4761 3579357 SGTC_3089 9117425 49.47 µM -2.42770588503644 0.0131504188003444 no 3263 0.00759732991598123 4735 9401657 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -2.43404668165519 0.0129447755930277 no 3264 0.0074655346599816 4753 91467 include heat shock SGTC_2970 9090938 41.86 µM -2.43893013657725 0.0127882976091828 no 3265 0.00736540792710935 4743 17217104 SGTC_966 1300-0360 30.2 µM -2.43968007966546 0.0127644130981555 no 3266 0.00735013694858288 4749 70588 SGTC_2493 resveratrol 26.09 µM -2.45875434527618 0.0121697688453104 no 3267 0.00697099899984465 4751 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1778 st046819 58.9 µM -2.46079331593607 0.0121076470675727 no 3268 0.00693151012140368 4783 671715 SGTC_3278 9139605 49.47 µM -2.46847831365186 0.0118759707114292 no 3269 0.00678444368061238 4739 7958859 SGTC_2846 9008642 19.48 µM -2.47169430989278 0.0117801667684539 no 3270 0.00672372247836193 4746 2992898 SGTC_1527 coumarin 137 µM -2.47313857793872 0.0117373609724647 no 3271 0.00669660988540508 4755 323 A hepatotoxic, DNA x-linker. SGTC_2339 9000433 200 µM -2.47716599007755 0.0116187072682526 no 3272 0.00662151482249755 4722 2988954 SGTC_122 0236-0016 402.397 µM -2.47738543728444 0.0116122720445369 no 3273 0.00661744448595528 4744 6808838 SGTC_2925 9010536 32.5 µM -2.49541708836319 0.0110939638527864 no 3274 0.00629045764234435 4724 2994177 SGTC_1891 st059073 26.2 µM -2.51343185477973 0.0105963507118937 no 3275 0.00597814371935506 4779 688754 SGTC_1218 1348-1416 30.7 µM -2.51516079123134 0.010549631752378 no 3276 0.00594890537939769 4753 6787668 SGTC_2147 5545932 89.7195 µM -2.5198084042539 0.0104249334691353 no 3277 0.00587093640689107 4779 797404 SGTC_3213 9129884 49.47 µM -2.52121429029112 0.0103874666603908 no 3278 0.00584753031803003 4732 17190742 SGTC_2920 7982904 15.77 µM -2.52234991371125 0.0103572880952655 no 3279 0.00582868421196493 4742 6456808 SGTC_2278 7948257 134.34 µM -2.52253500655736 0.0103523766064393 no 3280 0.00582561763770547 4759 1247028 SGTC_950 1165-0508 94.1 µM -2.52880359016948 0.0101872325766143 no 3281 0.00572260277454275 4742 6148369 SGTC_1339 1486-1321 22.7 µM -2.53068736858885 0.0101380561450739 no 3282 0.00569196324451062 4770 3469382 SGTC_2565 isoliquiritigenin 100 µM -2.53142924070744 0.0101187463344955 no 3283 0.00567993677033065 4725 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_184 1494-0393 24.714 µM -2.53708579173827 0.00997256708713162 no 3284 0.00558897787146857 4740 3090647 SGTC_1909 st060837 51.5 µM -2.57060062765078 0.0091437106013229 no 3285 0.00507611638811064 4725 678937 SGTC_106 0092-0003 11.579 µM -2.57157066931271 0.00912064639893248 no 3286 0.00506191755193383 4749 1072148 SGTC_2676 harmalol 100 µM -2.57205998209976 0.00910903158904539 no 3287 0.00505476873828756 4777 5459187 A monoamine oxidase inhibitor SGTC_722 3534-0461 190 µM -2.58221428741615 0.00887090490939981 no 3288 0.00490843046788319 4766 658262 SGTC_1043 0916-0009 19.3 µM -2.58579873927451 0.00878815895154252 no 3289 0.00485768204616997 4767 3101130 SGTC_1565 sinapyl alcohol 95.1 µM -2.58700679670768 0.00876042416501798 no 3290 0.00484068412427687 4755 5280507 A phenol propionate derived from cinnamic acid. SGTC_426 0988-0037 14.6 µM -2.59773587767802 0.00851745238666734 no 3291 0.00469203219765195 4749 5383008 SGTC_2381 9035592 200 µM -2.59844973656465 0.00850149812677807 no 3292 0.0046822876903102 4766 4749657 SGTC_2757 clomiphene 4.22 µM -2.60236944973304 0.00841436168896906 no 3293 0.0046291028239876 4743 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2062 5245942 200 µM -2.6067836164134 0.00831717283557177 no 3294 0.00456985488158516 4768 1376160 SGTC_880 0833-0487 87.2 µM -2.61233574327126 0.00819632961845654 no 3295 0.00449629465951431 4765 76075 SGTC_3311 9131146 2.8755 µM -2.64031696752975 0.00761049596327996 no 3296 0.00414142598608024 4769 4900406 YPR165W RHO1 SGTC_1330 1469-0054 61.8 µM -2.64265912611928 0.00756317372313273 no 3297 0.00411289012614755 4755 7102664 SGTC_1179 1021-1431 9.29 µM -2.66295345161883 0.00716386919432451 no 3298 0.00387290641291152 4781 2840958 SGTC_2205 7238770 200 µM -2.66665961324728 0.00709299068977425 no 3299 0.00383046094901439 4769 279867 SGTC_2454 5-benzylidenerhodanine 10.36 µM -2.67836498495458 0.00687317791606183 no 3300 0.00369912760866951 4785 1273210 SGTC_298 1391-0729 10 µM -2.68254583026017 0.00679613740372791 no 3301 0.00365320699542815 4762 3237558 SGTC_676 falcarinol 140 µM -2.68518539595304 0.00674789185707768 no 3302 0.00362447918594035 4767 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_454 lyso-paf C-16 6.67 µM -2.68548032288519 0.0067425200721639 no 3303 0.00362128196222463 4765 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -2.72699250092199 0.00602310184392983 no 3304 0.00319572458161079 4755 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1531 st059297 52.4 µM -2.73112589368523 0.00595533548413388 no 3305 0.00315591777784367 4787 7566702 SGTC_1661 st013063 9.66 µM -2.73472582260759 0.00589686687843183 no 3306 0.00312161273149399 4793 721395 SGTC_44 0929-0055 61.211 µM -2.74510094827806 0.00573119629365219 no 3307 0.00302461433670809 4656 1379590 SGTC_963 1269-2853 151 µM -2.76338330654931 0.00544929389252678 no 3308 0.00286027717517812 4779 3668223 SGTC_3083 9117465 49.47 µM -2.80782035695766 0.00481484491415373 no 3309 0.00249390210473625 4765 16420915 SGTC_3266 9136860 49.47 µM -2.81761722738404 0.00468416412057331 no 3310 0.00241907247893709 4616 4871271 YPR165W RHO1 SGTC_3242 9133940 49.47 µM -2.8308324394115 0.00451290143902498 no 3311 0.00232135180463387 4790 17248444 SGTC_1905 st060207 84.5 µM -2.8379394299589 0.00442312955858541 no 3312 0.00227028990479833 4780 1948547 SGTC_2755 lomerizine 42.69 µM -2.84944104691664 0.00428122353378378 no 3313 0.00218980607030049 4759 3949 A calcium channel blocker. SGTC_3247 9135149 49.47 µM -2.86071126958162 0.00414613488913896 no 3314 0.00211345906984032 4787 8934436 YOR116C RPO31 SGTC_1656 st012921 11 µM -2.87020054378283 0.00403536434969982 no 3315 0.00205105770467356 4759 6732821 SGTC_2351 9026858 72.31 µM -2.89328946190079 0.00377682971158268 no 3316 0.0019061488984341 4761 1409300 SGTC_984 1492-0255 2.91 µM -2.90821999173144 0.00361765479868729 no 3317 0.00181746266111095 4775 1585198 SGTC_3228 9131799 49.47 µM -2.92698459534945 0.00342615559151017 no 3318 0.00171132916542707 4796 17015818 SGTC_3328 9140624 29.0385 µM -2.94460959249936 0.00325463368408945 no 3319 0.0016168120196315 4783 4904392 SGTC_539 4859-0462 2.54 µM -2.95360376766729 0.00317011569759346 no 3320 0.00157043496850661 4780 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2981 9013952 38.96 µM -2.9646228746537 0.00306926476361395 no 3321 0.00151527094861981 4750 2996344 SGTC_1707 st032323 6.317 µM -3.01796291124865 0.0026207585057371 no 3322 0.00127240023786547 4699 3132057 YMR211W DML1 SGTC_1207 2099-0101 141 µM -3.01949833468688 0.00260877347509215 no 3323 0.00126596842489041 4799 5837381 SGTC_3229 9132204 49.47 µM -3.02107899926706 0.00259648705667649 no 3324 0.00125937817574518 4807 17682924 SGTC_2490 carminic acid 95.39 µM -3.05886390179779 0.00231792308746333 no 3325 0.00111089029690539 4781 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2777 climbazole 1.536 µM -3.06754638517191 0.00225786517342645 no 3326 0.00107911980939987 4677 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_107 0358-0022 2.6945 µM -3.07124082196118 0.00223274055708903 no 3327 0.00106585570982135 4798 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2418 pentamidine 31.67 µM -3.08245855572405 0.00215799725906826 no 3328 0.00102649157832883 4775 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2436 5633522 8.09 µM -3.10349462723568 0.0020239219670914 no 3329 0.000956248537152512 4786 5724242 SGTC_424 splitomicin 100 mM -3.10353501781585 0.00202367197424158 no 3330 0.000956118019144055 4784 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1658 st012944 20 µM -3.11869325197216 0.00193180684116932 no 3331 0.000908274859773588 4738 24207260 SGTC_431 k089-0097 107 µM -3.1265848109807 0.00188549553040494 no 3332 0.000884247434425446 4628 5499420 SGTC_2413 inermin 26.06 µM -3.16896174888175 0.00165362360371419 no 3333 0.000764922637834145 4790 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1528 arabinosylhypoxanthine 74.6 µM -3.19413864032104 0.00152847785958234 no 3334 0.000701243729033245 4800 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1791 st048313 56.1 µM -3.21211681396104 0.00144446829568279 no 3335 0.000658803942821397 4799 1204976 SGTC_1652 st011932 78 µM -3.24965178684258 0.0012825015211247 no 3336 0.00057773198355172 4786 1551076 SGTC_2916 7875993 68.79 µM -3.2689340864575 0.00120591891190245 no 3337 0.000539767231538096 4784 1299250 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -3.35064525249903 0.000925653837918861 yes 3338 0.000403117568800239 4780 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1657 st012939 43.4 µM -3.39432374694331 0.000801698322692194 yes 3339 0.000343991544939965 4800 24207257 SGTC_689 0833-0039 98 µM -3.39794600581041 0.000792137579627624 yes 3340 0.000339469093128527 4781 5374726 SGTC_1012 4112-3522 18 µM -3.45586939262915 0.000652840517533799 yes 3341 0.000274260517078672 4801 3112398 SGTC_918 glabranin 770.725 nM -3.53295683600763 0.000502401818348951 yes 3342 0.000205469779721727 4792 124049 Also referred to as licorice root. SGTC_2921 7974240 10.71 µM -3.61570565192072 0.000377075740309555 yes 3343 0.000149765286679444 4800 2979074 YDR527W RBA50 SGTC_2166 5933061 31.504 µM -3.63349749568036 0.000354236348495227 yes 3344 0.000139802581075515 4783 2877375 SGTC_329 k048-0121 21.3 µM -3.68259012845599 0.000297709921905792 yes 3345 0.000115438101276633 4803 6832902 SGTC_690 glyoxal 20.3 µM -3.76329683804518 0.000222677285904158 yes 3346 8.38439811308532e-05 4761 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1840 st055363 71 µM -4.06185709019066 7.23528501846526e-05 yes 3347 2.4341939131298e-05 4808 676033 SGTC_3152 9099253 49.47 µM -4.11680044438312 5.83284589179419e-05 yes 3348 1.9208421471642e-05 4758 25236131 SGTC_2927 9011802 47.9 µM -4.32392503528781 2.52732596774379e-05 yes 3349 7.66386997417039e-06 4801 43912568 SGTC_2409 alverine citrate 63.97 µM -4.36671173146195 2.1162389139655e-05 yes 3350 6.30655081808575e-06 4792 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1547 harmine 94.2 µM -4.56426398576437 9.12866688129333e-06 yes 3351 2.50624869611087e-06 4798 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3330 9141424 71.43 µM -5.15982274707102 5.85788137049343e-07 yes 3352 1.23591878319662e-07 4808 27261020 SGTC_1552 6-methylflavone 10.6 µM -5.528874154786 9.10152314739653e-08 yes 3353 1.61146214845924e-08 4808 689013 SGTC_2411 st077133 39.94 µM -5.64884465356777 4.83878500634782e-08 yes 3354 8.07648691504848e-09 4809 1403142 YNL221C POP1 SGTC_1844 rapamycin 4 nM -5.8129080243484 1.99688825259096e-08 yes 3355 3.06983994772328e-09 4786 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3324 9138759 60.749 µM -8.62156942069845 1.16552656706788e-16 yes 3356 3.30213138914125e-18 4810 45595710