SGTCid condition conc unit MPP10|YJR002W.score MPP10|YJR002W.strain.pval MPP10|YJR002W.strain.significant MPP10|YJR002W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1932 st074806 40.9 µM 4.41354236079848 1.31698241003086e-06 yes 1 5.08464043839881e-06 7 17251235
SGTC_1326 1431-2094 10.8 µM 4.27925415256892 2.5891683178251e-06 yes 2 9.3760319760379e-06 4 616278
SGTC_1421 4029-0249 71.4 µM 4.13396149870141 5.26708822283357e-06 yes 3 1.78281616578083e-05 2 2894095
SGTC_1948 st076329 66.6 µM 4.03204690267098 8.55442145463712e-06 yes 4 2.76465740913655e-05 3 24208413
SGTC_270 tamoxifen 5.46 µM 4.00149850256664 9.8720382433968e-06 yes 5 3.14712968061685e-05 5 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_96 0929-0093 37.281 µM 3.92125164716575 1.43162898720467e-05 yes 6 4.40451043262649e-05 5 6991579
SGTC_937 3122-0005 46.7 µM 3.70417012331879 3.78391876840846e-05 yes 7 0.000106041948188257 6 759535
SGTC_1365 1672-3266 55.4 µM 3.68926702827561 4.03777241575705e-05 yes 8 0.000112450534815801 8 6415873
SGTC_2489 cantharidin 73.42 µM 3.68919914654674 4.03896468445135e-05 yes 9 0.0001124805397929 9 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1221 2958-7315 257 µM 3.6738639520833 4.31700909361321e-05 yes 10 0.000119454986189006 2 4562705
SGTC_800 3448-7362 155 µM 3.56006922617652 7.02149533978119e-05 yes 11 0.000185378521612113 55 15991913
SGTC_1219 1469-0211 33.1 µM 3.46451820254074 0.000104549490494582 yes 12 0.000265591095131029 7 6822282
SGTC_1946 st076057 65.1 µM 3.45274319605867 0.000109734926556814 yes 13 0.000277458506550831 3 953009
SGTC_2186 6124449 200 µM 3.4327485171539 0.000119097053720381 yes 14 0.000298748010544568 26 3834182 YLR033W RSC58
SGTC_2811 7967822 32.47 µM 3.42882182093436 0.000121021567516325 yes 15 0.000303103681407997 9 2232244
SGTC_114 0364-0001 490.298 µM 3.37592046119453 0.000149961972672901 yes 16 0.000367845922025738 14 4003655
SGTC_2829 7992743 58.44 µM 3.23374308815527 0.000263060454660301 yes 17 0.00061089654640853 11 16462845
SGTC_75 0159-0059 199.013 µM 3.22473676629718 0.000272403867071939 yes 18 0.000630442731184305 19 5377270
SGTC_23 0213-0011 39.996 µM 3.21433672369362 0.000283577461036437 yes 19 0.000653731248703971 9 627608
SGTC_2970 9090938 41.86 µM 3.20614031805364 0.00029268268195272 yes 20 0.000672641852934255 16 17217104
SGTC_1832 st054113 55 µM 3.16383212245322 0.000344167085696882 yes 21 0.000778532908451836 6 1251267
SGTC_420 mitomycin C 81.9 mM 3.15061969669953 0.000361895282859552 yes 22 0.000814622409195829 12 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2116 5511452 16.8835 µM 3.13220446216859 0.000388022566831445 yes 23 0.000867495017930286 11 870744
SGTC_1700 st030840 7.9285 µM 3.10723283194166 0.000426254651568534 yes 24 0.000944237988681646 21 5499307
SGTC_653 0203-0016 55.2 µM 3.09952957201807 0.00043873578015072 yes 25 0.000969141137383003 10 295302
SGTC_1378 2093-0007 380 nM 3.01638240495944 0.000596784688363501 yes 26 0.00127905210373178 17 3618014
SGTC_424 splitomicin 100 mM 2.98942104765665 0.00065839526038876 yes 27 0.00139753336295171 17 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1796 st049173 110.4 µM 2.98626003337634 0.000665990858396974 yes 28 0.00141206193866962 10 94134
SGTC_1496 4469-0713 57.4 µM 2.88827438218307 0.000945583970397017 yes 29 0.00193680904678263 12 746691
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.88256113864503 0.000964818542903371 yes 30 0.00197228289625608 19 5393153
SGTC_2894 9048625 32.47 µM 2.77663257117192 0.00139313798234588 no 31 0.00274626153737039 29 4092861
SGTC_1189 1431-2119 7.28 µM 2.6685368131126 0.00200322849855708 no 32 0.00380912147146186 29 3107275
SGTC_2967 9089538 49.85 µM 2.63299530104479 0.00225152557923827 no 33 0.00423177591395896 35 728216
SGTC_2185 6113692 200 µM 2.59265834000852 0.00256686051286637 no 34 0.00476186649973913 31 874150
SGTC_2576 guaiol 23.12 µM 2.58317586246866 0.00264655786526854 no 35 0.0048947703924011 36 227829
SGTC_2468 5987765 72.9 µM 2.58283649799619 0.00264945110406594 no 36 0.00489958750980567 18 26772094
SGTC_2074 5212007 75.395 µM 2.54777478703606 0.00296422087034362 no 37 0.00542062173351826 16 758611
SGTC_2396 5342950 42.78 µM 2.5277586304573 0.00315866776818838 no 38 0.00573966202552971 74 1886677
SGTC_2207 7258803 200 µM 2.50666413631657 0.00337594543259339 no 39 0.0060938228697824 13 3666799
SGTC_2479 5617353 43.85 µM 2.47759618688626 0.00369735310880648 no 40 0.00661353755625803 40 2731746
SGTC_1013 4112-3890 241 µM 2.42248242984052 0.00438298419767522 no 41 0.00770743558768004 34 705171
SGTC_2380 9035439 200 µM 2.39905596599033 0.00470732758978904 no 42 0.00821870108738936 27 6462575
SGTC_2347 9049783 174.81 µM 2.39202000884135 0.00480883703908667 no 43 0.00837796443908688 28 6467988 YPL169C MEX67
SGTC_1342 1486-1464 234 µM 2.36209392641957 0.0052627262561058 no 44 0.00908601872877221 31 3253938
SGTC_621 3584-0052 32.1 µM 2.35515233852636 0.00537330514314169 no 45 0.00925755674622074 33 2273927
SGTC_2750 bromebric acid 70.15 µM 2.34665120390906 0.00551153822287862 no 46 0.00947148922525714 46 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1041 0206-0046 107 µM 2.34516426320408 0.00553603872148 no 47 0.00950934927291367 32 50494
SGTC_2324 6149169 200 µM 2.33783419606108 0.00565823671701229 no 48 0.00969792546662132 28 2888231
SGTC_2910 7948405 25.97 µM 2.30830592205784 0.00617509605468708 no 49 0.0104910636486218 23 2971328
SGTC_1939 st074455 53.6 µM 2.30179122421959 0.00629460818675961 no 50 0.0106734743491479 34 1644229
SGTC_617 3770-0098 35 µM 2.30171998702483 0.00629592627369015 no 51 0.0106754841529653 49 5962639
SGTC_2714 st079313 56.9 µM 2.28815637940193 0.00655138725140107 no 52 0.0110642079723004 26 2939799
SGTC_1938 st074717 56.4 µM 2.27202249399392 0.00686716115743426 no 53 0.011542575875766 15 17250979
SGTC_2221 6807166 181.081 µM 2.26158964257452 0.00707844130052099 no 54 0.0118613842633428 16 674925
SGTC_1401 3807-4679 7.6 µM 2.25792235163184 0.00715406024843599 no 55 0.0119752504195717 38 3291456
SGTC_2129 girgensonine 121.053 µM 2.25782879771124 0.00715599860128943 no 56 0.0119781675440805 66 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1138 3761-0006 1.03 µM 2.25775572717428 0.00715751287912576 no 57 0.0119804464005118 12 12061087
SGTC_1334 1486-0610 236 µM 2.24763336195166 0.00737003501798859 no 58 0.0122997892024223 39 3742339
SGTC_358 0075-0058 9.45 µM 2.24543991746613 0.00741681354985946 no 59 0.0123699526336731 40 1069125
SGTC_193 1273-0060 1.558 µM 2.21763872105002 0.00803278558183063 no 60 0.0132897377676367 31 2847393 YHR072W ERG7
SGTC_2101 5377231 179.231 µM 2.21150244522292 0.00817465125244095 no 61 0.0135005313670238 35 2844213
SGTC_1164 k060-0068 93.7 µM 2.20506410010139 0.00832586246498179 no 62 0.0137247984044988 37 5963676
SGTC_3195 9113082 49.47 µM 2.20078211740271 0.0084277841288127 no 63 0.0138757260763067 24 17018038
SGTC_2400 5203494 178.7 µM 2.18999269344705 0.0086894696563117 no 64 0.0142623833620539 60 6777674
SGTC_1146 3579-1023 7 µM 2.18891943067984 0.0087158860495247 no 65 0.0143013482654442 38 X1146
SGTC_2439 5492030 7.2 µM 2.1764274499585 0.00902857114469986 no 66 0.0147616565469638 37 5722370
SGTC_1579 chlormadinone acetate 49.4 µM 2.15172625809435 0.00967589573933501 no 67 0.0157094603860369 45 45114258 A steroidal progestin.
SGTC_2049 5262831 67.185 µM 2.1516486876457 0.00967799084183744 no 68 0.0157125171857263 47 763417
SGTC_2064 5220758 200 µM 2.13484532331801 0.0101412811284186 no 69 0.0163868233665806 69 788518
SGTC_2239 6685329 187.64 µM 2.09895917720731 0.0111959199525301 no 70 0.0179102497505682 34 805680
SGTC_1712 st032288 53.4 µM 2.08952351423618 0.0114885754500368 no 71 0.018330311760261 85 2883011
SGTC_889 0919-1524 82.7 µM 2.0849273957216 0.0116335190866462 no 72 0.0185379457357368 40 3905452
SGTC_532 1548-0774 215 µM 2.0832089808939 0.0116881175185779 no 73 0.0186160894251913 46 5932993
SGTC_1079 idarubicin 2.36 µM 2.07896600493931 0.0118238812685824 no 74 0.0188102375828569 50 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 2.0648875384874 0.0122842023668978 no 75 0.0194668212263388 61 6728940
SGTC_88 0180-0332 8.668 µM 2.05602418029023 0.0125819038260471 no 76 0.0198900927684886 49 3101745
SGTC_2899 9053889 58.44 µM 2.04994604277532 0.0127896475017432 no 77 0.0201848482332209 38 6470052
SGTC_2612 dictamnine 15.46 µM 2.03896772819393 0.0131723998204223 no 78 0.0207266242490043 88 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_26 0302-0163 425.158 µM 2.00990062697172 0.0142339441932005 no 79 0.0222208536985605 63 3100915
SGTC_1524 corynanthine 62.1 µM 2.00618701059543 0.0143747376223056 no 80 0.022418149605103 54 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2312 7706453 155.7 µM 2.00311384039037 0.0144921551646265 no 81 0.0225825353778345 64 976098
SGTC_2461 5755302 26.15 µM 2.00221389764746 0.0145266954469845 no 82 0.0226308658098444 52 2788904
SGTC_72 0744-0168 198.391 µM 2.00129662428803 0.014561973778714 no 83 0.0226802166623066 48 677577
SGTC_2126 5251174 33.877 µM 1.99455281380668 0.0148236115880315 no 84 0.0230458371738916 51 790722
SGTC_593 1203-0218 61.7 µM 1.98510428538722 0.0151969773724488 no 85 0.0235664350600981 50 3666956
SGTC_1304 1165-0502 251 µM 1.98225147963252 0.0153112842295633 no 86 0.0237255507831776 59 767425
SGTC_2717 st081029 62.2815 µM 1.96919797480648 0.0158437807925793 no 87 0.0244651806842531 33 5292846
SGTC_65 0798-0905 34.986 µM 1.96820175282432 0.0158850645209904 no 88 0.0245224143401539 67 3602145
SGTC_1924 st058459 75.1 µM 1.96541843853769 0.0160008950383454 no 89 0.0246829135633152 38 688683
SGTC_2708 st078559 56 µM 1.95451490727127 0.0164616560014506 no 90 0.0253201768212308 32 17250902
SGTC_1007 4101-0031 70 µM 1.95010300052871 0.0166512967342698 no 91 0.0255819218518156 55 1146276
SGTC_1676 st018489 23.4 µM 1.94825431221667 0.0167313144970736 no 92 0.0256922704902778 48 3696235
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.94712443543668 0.0167803813411737 no 93 0.0257599090701504 31 77254
SGTC_2252 omeprazole 400 µM 1.94052342592912 0.0170695083304626 no 94 0.0261580550200967 30 4594 A proton pump inhibitor.
SGTC_1104 tacrolimus 29.8 µM 1.92599143084811 0.0177210514862385 no 95 0.0270527219167331 75 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1004 4084-0029 199 µM 1.92555404591123 0.0177409861911344 no 96 0.0270800407093123 46 716894 YLR208W SEC13
SGTC_934 2950-0684 338 µM 1.92512427900257 0.0177605923220005 no 97 0.0271069061044197 52 1121253
SGTC_2176 5809774 33.9695 µM 1.92228663463813 0.0178905112885527 no 98 0.0272848504023633 25 2870539
SGTC_452 diindolylmethane 8 µM 1.92065936253824 0.0179653795011494 no 99 0.0273873329846428 43 3071 Inhibits expression of several cancer promoting factors.
SGTC_633 0437-0093 97.7 µM 1.90108751197681 0.0188869792071898 no 100 0.0286452755173891 58 2831118
SGTC_1499 4480-0877 67.3 µM 1.89079798155716 0.0193874183751963 no 101 0.0293256583686172 47 2861909
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.89032870799194 0.0194105079656675 no 102 0.0293570058054251 61 688662
SGTC_3004 9076122 71.4286 µM 1.88240498229974 0.0198039192292229 no 103 0.029890524980581 58 44782551
SGTC_2463 5473429 200 µM 1.88100069995746 0.0198743428602908 no 104 0.0299859118133146 47 5399405
SGTC_2545 solidagenone 89.61 µM 1.88029566671571 0.0199097797685088 no 105 0.0300338967756774 27 6708572 An anti ulcer agent
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.87325694640059 0.0202665141207921 no 106 0.030516456010809 74 65057 A dermal irritant. YDR527W RBA50
SGTC_3313 9133968 57.047 µM 1.8711497889348 0.0203743567124422 no 107 0.0306621610576108 38 1494643
SGTC_2172 5754775 163.918 µM 1.85302505398296 0.0213222083538375 no 108 0.0319393838577381 83 2263357
SGTC_1222 0366-0074 1.18 µM 1.8529742041458 0.0213249191768443 no 109 0.0319430280494001 60 286520
SGTC_4 0960-0234 25.671 µM 1.84648935437837 0.0216730254534701 no 110 0.0324105918505698 54 6821112
SGTC_1157 4092-0394 27.6 µM 1.84644694439383 0.0216753177265709 no 111 0.0324136681364078 51 3659885
SGTC_1885 st057546 99.9 µM 1.84498580239801 0.0217544181064222 no 112 0.0325198019630432 57 702008
SGTC_2069 5228469 200 µM 1.84332518856823 0.0218446130043583 no 113 0.0326407728105514 63 2835210
SGTC_1351 1496-0003 46.5 µM 1.84042894092318 0.0220026761048459 no 114 0.0328526438965553 43 3891978
SGTC_579 4491-1009 110 µM 1.83810559898769 0.0221301697548279 no 115 0.0330234231616363 70 1271041
SGTC_3327 9140648 26.9345 µM 1.82683672891774 0.0227574299363265 no 116 0.0338621608432552 105 8029710
SGTC_202 3594-0513 34.79 µM 1.82679132634754 0.0227599871780718 no 117 0.0338655752557342 64 708429
SGTC_2553 4-methylesculetin 85.09 µM 1.8206160660827 0.0231100643377046 no 118 0.0343326194489705 50 5319502
SGTC_2262 9014885 67.46 µM 1.8173705795283 0.0232958623211526 no 119 0.034580194725528 27 6457424
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.81160309514402 0.0236291423312105 no 120 0.0350237731802164 87 279621
SGTC_2001 4023502 57.655 µM 1.81001942067555 0.0237213552059799 no 121 0.0351463877722619 63 108941 YCR052W RSC6
SGTC_2398 5228213 48.84 µM 1.79787412696377 0.0244386480548623 no 122 0.0360984785309471 92 80771 YMR134W ERG29
SGTC_1710 st031758 61.5 µM 1.79488992472224 0.0246176531578128 no 123 0.0363356197527116 65 5394341
SGTC_1309 pyrazolanthrone 13.4 µM 1.78994086524158 0.0249169435540136 no 124 0.0367317092086326 74 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1556 plumbagin 1.48 µM 1.77647004823546 0.0257470715069053 no 125 0.0378277372133621 83 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_458 nppb 133 µM 1.76213528574068 0.0266557353643522 no 126 0.0390232213926949 46 4549 A chloride channel blocker.
SGTC_1400 3771-8998 51.5 µM 1.76152719028834 0.0266948666861605 no 127 0.0390746075440468 31 670767
SGTC_1877 wortmannin 25 µM 1.74790644425655 0.0275840209876047 no 128 0.0402401143947879 70 312145 A covalent inhibitor of PI 3-kinase.
SGTC_831 k061-1017 217 µM 1.74210983856466 0.0279698391927503 no 129 0.0407446131754202 92 1240153
SGTC_1851 st056236 18.9 µM 1.73617165018247 0.0283697310818969 no 130 0.0412667441976144 68 5393171
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.73581597067266 0.02839383365163 no 131 0.0412981896474867 54 17037758
SGTC_2681 menadione 3.18 µM 1.73373323318265 0.0285353123022436 no 132 0.041482713507668 77 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_404 fumagillin 50 µM 1.7287462205648 0.0288764604458286 no 133 0.0419272625481422 71 12015870 A methionine aminopeptidase binder.
SGTC_1788 fluconazole 20 µM 1.71983475905918 0.0294945102201231 no 134 0.0427312411755856 82 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_516 3992-2719 87.3 µM 1.71592711995719 0.0297689651958351 no 135 0.0430876911505682 53 5350887 YDR037W KRS1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.71468897394914 0.0298563677861345 no 136 0.043201133086443 47 2724278 An inhibitor of dopamine biosynthesis.
SGTC_251 melphalan 456.522 µM 1.71063854553568 0.0301437820439859 no 137 0.0435739293823707 87 460612 A DNA alkylator.
SGTC_2785 7756463 72.73 µM 1.70548695453712 0.0305126437311499 no 138 0.0440518216309942 96 2201551
SGTC_1359 1582-0056 520 nM 1.70219532015549 0.0307502816493754 no 139 0.0443593798834625 73 3661189
SGTC_718 1130-0073 349 µM 1.69932697751401 0.0309586077249817 no 140 0.0446287961217763 72 6740020
SGTC_2738 aclarubicin 5.55 µM 1.69627202786619 0.0311817700314581 no 141 0.0449171876450572 43 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1027 k015-0025 8.67 µM 1.69017089488994 0.0316314373188026 no 142 0.0454976324243947 70 3598955
SGTC_518 1021-0119 62.6 µM 1.68982653188134 0.0316569766029376 no 143 0.0455305731584426 89 1097762
SGTC_2304 7443016 91.4 µM 1.68738973890971 0.0318381858464214 no 144 0.0457642177929947 65 939854
SGTC_19 0279-0214 38.434 µM 1.67402874365624 0.0328470503275143 no 145 0.0470624752182369 81 3566274 YBR002C RER2
SGTC_1382 3002-2117 298 µM 1.67052931235984 0.0331155976130491 no 146 0.0474073424671571 68 1497314
SGTC_1185 1319-0113 81.3 µM 1.67034328575877 0.0331299238303387 no 147 0.047425731830803 71 4672763
SGTC_1246 0422-0085 105 µM 1.66899776687814 0.0332336965661325 no 148 0.0475589111881106 99 264295
SGTC_1050 3232-1156 69.3 µM 1.66343843510994 0.0336653005106504 no 149 0.0481123524186458 99 700529
SGTC_199 4063-0024 41.6 µM 1.66283496881661 0.03371242747142 no 150 0.0481727373646707 36 306215
SGTC_2702 st077768 96.8 µM 1.6622207435279 0.0337604503753667 no 151 0.0482342611491054 60 6484119
SGTC_1618 st003135 44.5 µM 1.65863244636906 0.0340421257227046 no 152 0.0485949397324023 76 1270615
SGTC_2809 7964133 12.99 µM 1.65851436094219 0.0340514279776606 no 153 0.0486068456662582 87 1253665
SGTC_556 4058-0063 51.5 µM 1.65669253261637 0.0341952087398812 no 154 0.0487908267534913 72 6615692
SGTC_1912 st060209 90.8 µM 1.6521755402219 0.0345538485550252 no 155 0.0492493855889481 95 688787
SGTC_1162 k048-0130 20.1 µM 1.64753837664781 0.0349252381295072 no 156 0.0497237174367769 78 6797406
SGTC_1388 3346-4487 254 µM 1.64074003872122 0.0354756330393881 no 157 0.050425694912938 78 3345614
SGTC_2379 9035213 200 µM 1.64043225753635 0.0355007183985647 no 158 0.0504576614331114 87 646551
SGTC_1653 st012112 65 µM 1.63614433576021 0.0358517157571064 no 159 0.0509046915399722 59 720429
SGTC_2170 morpholine 200 µM 1.6304861741808 0.0363192233060844 no 160 0.0514993924693776 65 121171 Reacts with secondary amines.
SGTC_2682 pyrogallin 40.03 µM 1.62898641317662 0.0364439747484579 no 161 0.0516579476178014 78 822798 An ATP competetive kinase inhibitor.
SGTC_2149 5554786 194.827 µM 1.62377188641358 0.0368804554987756 no 162 0.0522122511225167 73 745063 YPR165W RHO1
SGTC_449 xestospongin c 11.1929 µM 1.6230983539668 0.0369371437903406 no 163 0.0522841907222268 71 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2266 7929956 200 µM 1.60707162115102 0.0383071904642595 no 164 0.054019328900055 81 2967153
SGTC_822 1487-0950 154 µM 1.60376047853982 0.0385953456542949 no 165 0.0543834295897315 65 1958375
SGTC_803 4488-1585 147 µM 1.6007927711694 0.0388551117534397 no 166 0.0547114126151325 81 747204
SGTC_160 3453-0671 289.699 µM 1.59943279885159 0.0389746262249242 no 167 0.0548622346777397 74 5322268
SGTC_2078 5212016 200 µM 1.59531640994725 0.0393382000475884 no 168 0.0553207489078133 74 1899708
SGTC_2290 7904846 200 µM 1.5912804389203 0.0396973456723062 no 169 0.0557732385077005 93 2962154
SGTC_1502 4534-4282 27.7 µM 1.59068383829935 0.0397506603556857 no 170 0.0558403729573421 80 3278949
SGTC_636 0kpi-0074 126 µM 1.58857016449593 0.039940015586931 no 171 0.0560787342599523 75 616434
SGTC_932 2857-0803 154 µM 1.58623536889954 0.0401500316500679 no 172 0.0563429636605258 89 674898
SGTC_2793 7325131 81.82 µM 1.58501568101779 0.0402600994348691 no 173 0.0564813857557915 83 4176441
SGTC_271 rotenone 740 µM 1.58405699148667 0.0403467859727116 no 174 0.0565903752075139 70 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3346 9158254 43.5805 µM 1.58184656096452 0.040547235024332 no 175 0.0568423014087413 101 17639500
SGTC_1466 k213-0079 57.5 µM 1.57747162479186 0.0409463517939404 no 176 0.0573435230715849 117 3657981
SGTC_620 0109-0052 432 µM 1.57494072053563 0.0411786923692832 no 177 0.0576350641291062 85 493037
SGTC_141 0443-0274 32.331 µM 1.56783869339488 0.0418363810275562 no 178 0.0584593911194198 78 1627241
SGTC_3043 9092303 49.47 µM 1.56087778903705 0.0424892295165291 no 179 0.059276294410051 80 25236084
SGTC_1199 1638-0010 4.46 µM 1.558133509722 0.0427488635403489 no 180 0.0596008012959052 93 3111136
SGTC_1423 4048-0112 5.59 µM 1.55759803405011 0.042799673681875 no 181 0.0596642825124977 87 X1423
SGTC_2662 daunorubicin 22.37 µM 1.5490178890834 0.0436205022401627 no 182 0.0606887098874232 108 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_255 tunicamycin 200.472 nM 1.548559947496 0.0436646663674964 no 183 0.0607437702210965 101 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1119 parthenolide 318.541 nM 1.54649446621374 0.0438643110399029 no 184 0.0609925977574667 100 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_247 mechlorethamine 29.705 µM 1.54444818404289 0.0440628253900418 no 185 0.0612398974054447 64 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1205 4161-2785 76 µM 1.54192816551313 0.0443082926351314 no 186 0.0615455253499316 80 3498106
SGTC_2823 7987624 58.44 µM 1.54067341016052 0.0444309248354672 no 187 0.0616981456887926 108 2239440
SGTC_891 0929-0073 133 µM 1.53145599289212 0.0453401842784499 no 188 0.0628283673472045 101 5603632
SGTC_1940 st075990 51.1 µM 1.5311128675969 0.0453743189763961 no 189 0.0628707500846183 84 1084979
SGTC_966 1300-0360 30.2 µM 1.53005318753008 0.045479868288592 no 190 0.0630017820947216 124 70588
SGTC_281 1672-3440 14.9 µM 1.52427881638065 0.0460584978786507 no 191 0.0637195382943107 91 6833000
SGTC_2316 5844804 197.44 µM 1.52410992830268 0.0460755101629362 no 192 0.0637406264904875 117 776813
SGTC_771 0250-0039 27.3 µM 1.5219382383924 0.0462947169606621 no 193 0.0640122783860242 109 3005115
SGTC_2523 spermine 47.74 µM 1.52032537005607 0.0464580584913106 no 194 0.0642146104187863 66 1103 A DNA binding polyamine.
SGTC_120 rhodamine 6G 52.259 µM 1.51680202723733 0.0468164904191322 no 195 0.0646583375354053 151 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1251 0490-5699 265 µM 1.51679519933232 0.0468171871737021 no 196 0.0646591997426129 95 3883818
SGTC_3339 9145883 14.936 µM 1.51660250061294 0.0468368545730318 no 197 0.0646835368368389 73 2030670
SGTC_1500 4488-1866 171 µM 1.51150309636159 0.0473597272041685 no 198 0.0653301601548775 91 2900003
SGTC_2795 7780010 54.55 µM 1.50875085974926 0.0476438681563765 no 199 0.0656812314418688 99 953673
SGTC_2695 st077686 51.995 µM 1.50748759281247 0.0477747442260338 no 200 0.0658428608648782 84 2876092
SGTC_1678 st019265 80.2 µM 1.5041396671949 0.0481229863032628 no 201 0.066272704253128 83 5367020
SGTC_2445 5742597 35.57 µM 1.50207401712984 0.0483388608879429 no 202 0.0665389971605169 114 1774255
SGTC_134 0269-0018 6.916 µM 1.50093037330993 0.0484587122337664 no 203 0.0666867856152379 104 4378915
SGTC_2354 9060492 162 µM 1.49923714164863 0.0486365954187537 no 204 0.0669060613901899 104 6471895
SGTC_368 fentichlor 4.58 µM 1.49043605272729 0.049569621648374 no 205 0.0680548094203732 91 7329 A pesticide.
SGTC_2669 eugenol 100 µM 1.48745514384434 0.0498888545833443 no 206 0.0684473209640029 58 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3068 9116768 49.47 µM 1.485896123339 0.0500564658330572 no 207 0.0686532995869803 110 41904888
SGTC_2748 diazoxide 86.69 µM 1.47811242105521 0.0509000238565248 no 208 0.0696888449951968 46 3019 A potassium channel activatior.
SGTC_2015 5119600 184 µM 1.47427163864268 0.0513204181493128 no 209 0.0702042340775595 117 2828786
SGTC_1591 genipin 88.4 µM 1.47374840258464 0.051377902308061 no 210 0.0702746726787859 105 442424 A DNA cross-linking agent.
SGTC_938 3126-1755 342 µM 1.4723147848126 0.0515356659396492 no 211 0.070467946310923 84 1777771
SGTC_66 0109-0187 42.4 µM 1.47229486742732 0.051537860474496 no 212 0.0704706343546736 72 759417
SGTC_2767 sibutramine 71.45 µM 1.47199707379495 0.0515706807971162 no 213 0.0705108338856982 78 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1194 1488-0194 225 µM 1.46872541265607 0.0519323511393042 no 214 0.0709536408907793 89 1391452
SGTC_3251 9135047 49.47 µM 1.46246537220019 0.0526299914652004 no 215 0.0718068633764464 81 17682963
SGTC_2415 st077333 57.7 µM 1.46155599124573 0.0527319518095759 no 216 0.0719314608073575 142 2766255
SGTC_310 1273-0058 1.06 µM 1.46042373904286 0.0528591195922198 no 217 0.0720868262229643 73 2734232
SGTC_291 SEC14.278 35.5 µM 1.4579500511955 0.0531377956914189 no 218 0.0724271556082835 96 1068044
SGTC_3149 9097855 49.47 µM 1.45359542214628 0.0536312002986989 no 219 0.0730292534309663 89 25236625 YMR079W SEC14
SGTC_671 0560-0003 407 µM 1.45322929606118 0.0536728493448482 no 220 0.0730800503396012 78 3238678
SGTC_431 k089-0097 107 µM 1.45228390423613 0.0537805118435731 no 221 0.0732113405355913 112 5499420
SGTC_2789 5281112 71.43 µM 1.45103558265953 0.0539229343158282 no 222 0.0733849761134158 101 765948
SGTC_1367 1812-0510 76.9 µM 1.44898584210181 0.0541574391475697 no 223 0.0736707682163605 92 1142582 YDR527W RBA50
SGTC_1489 4065-0444 182 µM 1.44808406724821 0.0542608638857075 no 224 0.073796770449166 92 2877968
SGTC_116 0155-0182 31.788 µM 1.44089286593805 0.0550912261249237 no 225 0.0748074759284913 103 771486
SGTC_2219 9098279 200 µM 1.44044363115527 0.0551434302480692 no 226 0.074870963529507 54 902349
SGTC_1127 asiatic acid 681.4 nM 1.43541626231826 0.0557303138427 no 227 0.075584257301128 104 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3314 9135860 59.4275 µM 1.43462938230688 0.0558226169138817 no 228 0.0756963685887388 94 25252478
SGTC_2052 5265182 7.135 µM 1.4300272863485 0.0563648726210832 no 229 0.0763545938979552 103 1239884
SGTC_655 k060-0012 42 µM 1.42834461165229 0.056564172239003 no 230 0.0765963465824847 119 5994525
SGTC_2263 7948595 193.29 µM 1.42687172887793 0.056739079015271 no 231 0.0768084355505024 91 2971371
SGTC_3069 9117009 49.47 µM 1.42643525961023 0.0567909920648021 no 232 0.0768713709846026 80 41904981
SGTC_2840 9008771 71.43 µM 1.42089514119302 0.057453181980372 no 233 0.0776736228723145 62 2992978
SGTC_1630 st005209 31.3 µM 1.4207413643704 0.0574716486299931 no 234 0.0776959812605146 100 3367314
SGTC_3118 9124250 49.47 µM 1.41784310446213 0.0578205669837708 no 235 0.0781182882035224 103 1504786
SGTC_223 busulfan 5 mM 1.41388348198266 0.058299950906473 no 236 0.0786980583099922 95 2478 A DNA alkylator.
SGTC_3042 9091578 49.47 µM 1.41232943464748 0.0584889473600526 no 237 0.0789264916928037 91 25236497
SGTC_3266 9136860 49.47 µM 1.41180811081903 0.0585524561432342 no 238 0.0790032348149712 125 4871271 YPR165W RHO1
SGTC_1767 st044992 70.3 µM 1.41055712279875 0.0587050750240984 no 239 0.0791876209791532 99 9600693
SGTC_558 k064-0027 21.3 µM 1.40956371276609 0.0588264920178441 no 240 0.0793342740622162 120 5088526
SGTC_361 000s-0510 1.45 µM 1.40564515909397 0.0593073499554592 no 241 0.0799147595922732 99 660
SGTC_615 k087-0205 167 µM 1.40228195634315 0.05972251198536 no 242 0.0804155331845797 111 9642773
SGTC_1200 1643-0193 18.4 µM 1.4013691248624 0.0598355861320045 no 243 0.080551860041667 120 5403974
SGTC_1908 st060353 56.5 µM 1.39985905006276 0.0600230100291529 no 244 0.080777765392955 131 4227716
SGTC_1338 1486-1223 76 µM 1.3950231115756 0.0606263202755532 no 245 0.0815044351355001 107 3444526
SGTC_1366 1683-0113 21.9 µM 1.38420143741565 0.0619935632989064 no 246 0.0831483916787029 112 708623
SGTC_2423 st077119 87.2 µM 1.38225699053679 0.0622417611452309 no 247 0.0834464034289343 110 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1736 st036774 51 µM 1.37887547683722 0.0626752377600827 no 248 0.0839665751885415 118 1272247
SGTC_1876 myriocin 605 nM 1.37733776343411 0.062873134041246 no 249 0.084203922475879 122 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1197 1601-0112 267 µM 1.37368456147485 0.0633452355507227 no 250 0.0847698159175872 118 7350313
SGTC_761 k216-0224 480 µM 1.37014329027646 0.0638055019091175 no 251 0.0853210883143539 131 1340404
SGTC_3150 9097574 49.47 µM 1.36886131242219 0.0639727630617076 no 252 0.0855213154925768 100 17217476
SGTC_773 4358-1457 44.6 µM 1.36797101724855 0.0640891213831646 no 253 0.0856605741653687 141 1186886
SGTC_1435 4092-0789 56.7 µM 1.36407190149093 0.0646006607993069 no 254 0.0862724686024768 136 2248285
SGTC_2013 4024628 200 µM 1.35991630277414 0.0651493343957314 no 255 0.086928205676827 129 5230760
SGTC_1641 st009299 47.1 µM 1.35967577823453 0.0651812017931851 no 256 0.086966273178858 120 4046054
SGTC_2408 sulbentine 18.36 µM 1.35189635305502 0.066218443441111 no 257 0.0882042371897716 131 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_790 1575-0012 79.1 µM 1.35064322512489 0.0663867137187999 no 258 0.0884048736366075 119 378741 YLR208W SEC13
SGTC_3144 9087057 49.47 µM 1.34796251512429 0.0667477915396509 no 259 0.0888352196463194 108 17249618
SGTC_2920 7982904 15.77 µM 1.34519565872972 0.0671220646349445 no 260 0.0892810289037654 124 6456808
SGTC_3049 9092223 49.47 µM 1.34203297590139 0.0675518666742286 no 261 0.0897926519050845 101 8623917
SGTC_1644 st010134 20.9 µM 1.34119718642087 0.0676658032324935 no 262 0.0899282198212263 123 3818134
SGTC_839 0122-0028 230 µM 1.34085526384388 0.0677124575979667 no 263 0.0899837246560457 179 759448
SGTC_2616 abietic acid 100 µM 1.33952843657925 0.0678937347470855 no 264 0.0901993517035753 123 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_194 1486-1323 56.904 µM 1.33739976447359 0.0681853462216984 no 265 0.0905460906502476 145 5178754
SGTC_2220 6782180 200 µM 1.3366197778238 0.0682924399958486 no 266 0.0906733899145836 78 833803
SGTC_1573 oleylamine 1.06 µM 1.33611351425295 0.068362020465295 no 267 0.0907560867217241 125 5356789 An amine of the fatty acid oleic acid.
SGTC_805 3852-0218 479 µM 1.33564368062629 0.0684266429587237 no 268 0.0908328828562096 112 6615355
SGTC_74 000s-0487 160.283 µM 1.334151027263 0.0686322602491125 no 269 0.0910771827790833 97 677548
SGTC_1707 st032323 6.317 µM 1.3284861283058 0.0694169545454118 no 270 0.0920087815873731 138 3132057 YMR211W DML1
SGTC_1282 0886-0010 32.4 µM 1.32598414448971 0.069765718182945 no 271 0.0924224746624796 137 2836211 YNL267W PIK1
SGTC_470 aa-861 153 µM 1.32580759707826 0.0697903788326517 no 272 0.0924517179774096 130 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1730 st033808 45.1 µM 1.32472741103175 0.0699414084535402 no 273 0.0926307891063833 117 1045166
SGTC_3127 9126946 49.47 µM 1.32146871239983 0.0703985576163735 no 274 0.0931725640924851 121 27243249
SGTC_1923 st058458 19.1 µM 1.32071656760971 0.0705043984599085 no 275 0.0932979438821285 148 3534982
SGTC_2905 7799065 20.05 µM 1.31812745915173 0.0708696698752753 no 276 0.0937304918894284 120 1296806
SGTC_546 peri-Naphthalide 147 µM 1.3160497871092 0.0711638378354019 no 277 0.0940786663626427 145 223824 A penicillin ester.
SGTC_1298 1079-1278 263 µM 1.31461846394734 0.0713670370522232 no 278 0.0943190807820316 113 2840950
SGTC_1622 st003707 19.4 µM 1.31416028773276 0.0714321765027925 no 279 0.0943961347158296 118 10140899
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.3128589285786 0.0716174411248835 no 280 0.0946152443622499 120 3256 An antibiotic and ribosome inhibitor.
SGTC_2650 prasterone 100 µM 1.31248139672506 0.071671256395984 no 281 0.0946788794452983 91 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_265 mycophenolic acid 32.932 µM 1.3098524061301 0.0720468663646879 no 282 0.0951228852337949 111 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_84 0443-0269 128.823 µM 1.30858231057005 0.0722288676466517 no 283 0.0953379381005631 123 6150058
SGTC_1660 st012960 28.1 µM 1.30304010061723 0.0730271772325363 no 284 0.0962805357545233 111 24207266
SGTC_668 1682-0499 62.6 µM 1.29861025724195 0.0736701014061451 no 285 0.0970388580343841 128 682214
SGTC_1514 1189-1591 158 µM 1.29422411880355 0.0743109369002901 no 286 0.0977940090439482 129 767698 YMR146C TIF34
SGTC_1064 honokiol 6.76 µM 1.29395391294704 0.0743505540097206 no 287 0.0978406702156791 142 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1785 bathophenanthroline 24 µM 1.29227894680107 0.0745964945355219 no 288 0.0981302800816332 153 72812 An iron chelator.
SGTC_1757 st041620 31.8375 µM 1.29180726567278 0.0746658648784588 no 289 0.098211949283156 99 5289815
SGTC_3253 9135987 49.47 µM 1.28546737943866 0.0756030587820229 no 290 0.0993145044033315 142 4182430
SGTC_1347 1493-0251 600 nM 1.283899956544 0.0758361391678621 no 291 0.0995884812362067 132 3986378
SGTC_3071 9117417 49.47 µM 1.28153357463925 0.0761890633433618 no 292 0.100003157410278 124 45595590 YGL055W OLE1
SGTC_2002 4023503 131 µM 1.27859226145367 0.0766294741408504 no 293 0.100520338240808 145 4736863 YCR052W RSC6
SGTC_2223 6903751 107.57 µM 1.27727631872094 0.0768271395934756 no 294 0.100752355574337 120 5598863
SGTC_2642 cholecalciferol 100 µM 1.27430407844056 0.0772750208805898 no 295 0.101277835838358 101 9821465 A vitamin D precursor, similar to steriods.
SGTC_2747 doxorubicin 7.63 µM 1.27281905142195 0.0774995385947522 no 296 0.101541129564791 82 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2035 5154463 94.595 µM 1.27199722124255 0.0776240018944011 no 297 0.101687053286455 153 2769623
SGTC_798 1287-0182 476 µM 1.27104820217112 0.0777679162453303 no 298 0.1018557504847 128 1649755
SGTC_1088 bifonazole 369 nM 1.26755062480534 0.0783000565919924 no 299 0.102479236979358 117 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1895 st058434 18.3 µM 1.26512643340663 0.0786705032765983 no 300 0.102913004308936 142 5393175
SGTC_100 0086-0128 49.5915 µM 1.26409257543975 0.0788288930853972 no 301 0.103098400586858 131 93297
SGTC_2684 capsaicin 100 µM 1.26353613904426 0.0789142405808548 no 302 0.103198283734592 140 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_16 erodoxin 22.806 µM 1.26044116420307 0.0793902328704266 no 303 0.103755129935383 162 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2742 clothiapine 36.27 µM 1.25981282240612 0.0794871336551638 no 304 0.103868446542968 85 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2891 9063876 19.48 µM 1.25968651430165 0.079506623271475 no 305 0.103891236069081 100 6472478
SGTC_262 fenpropimorph 62.5 µM 1.25844363404701 0.0796985953165598 no 306 0.104115679977553 138 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_845 0330-0138 4.51 µM 1.25494941515874 0.0802401818475577 no 307 0.104748561869197 154 9039800
SGTC_2617 dihydrotanshinone i 20.83 µM 1.25493335104809 0.0802426781118939 no 308 0.10475147786146 151 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_63 0099-0242 26.702 µM 1.25429107658608 0.0803425317184631 no 309 0.104868113082599 159 3898502 YLR359W ADE13
SGTC_1051 3253-3903 78 µM 1.24997764679731 0.081015569390156 no 310 0.105653856515922 153 5509239
SGTC_1608 st001473 40.5 µM 1.24990416279245 0.0810270720775421 no 311 0.105667279293669 169 7292267
SGTC_83 0170-0301 39.027 µM 1.24915766971299 0.0811439929087813 no 312 0.105803705529373 109 3089716
SGTC_535 2293-4129 48.2 µM 1.24648504551849 0.081563641468754 no 313 0.106293188012173 165 396118 YIL048W NEO1
SGTC_147 4466-0538 29.23 µM 1.24540767854214 0.0817332688983685 no 314 0.10649096610987 134 6742687 YHR072W ERG7
SGTC_657 3534-0529 86.7 µM 1.24332137976502 0.0820625047749827 no 315 0.106874714414328 139 1049549
SGTC_3216 9129716 49.47 µM 1.23917191270917 0.0827202946657446 no 316 0.107640919922356 123 8056934
SGTC_477 mead ethanolamide 10 µM 1.23742375377458 0.08299860465413 no 317 0.107964902340253 75 16061185
SGTC_1596 piperlongumine 63 µM 1.23703587097743 0.0830604516429691 no 318 0.108036882886436 114 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2333 9017922 200 µM 1.23568341264732 0.0832763690340256 no 319 0.108288132802637 120 3163164
SGTC_1718 roemerine 11.9335 µM 1.234985694723 0.0833879232355074 no 320 0.108417914092619 152 235224 An aporphine alkaloid with mutagenic activity.
SGTC_649 1123-0311 367 µM 1.2348999902575 0.0834016337836652 no 321 0.108433863544843 154 693629 YIL048W NEO1
SGTC_80 0159-0065 512.242 µM 1.23262862447921 0.0837656126813175 no 322 0.108857176177335 94 1548079
SGTC_373 0844-0104 25.9 µM 1.23006681528865 0.084177564539904 no 323 0.109336042751237 149 5375804
SGTC_3040 9091894 49.47 µM 1.22727597010724 0.0846280752554444 no 324 0.109859442074911 116 25236966
SGTC_145 3737-0113 38.366 µM 1.22645887177008 0.0847603165558156 no 325 0.110013021690041 174 6849351
SGTC_1008 4106-0037 6 µM 1.22369647253606 0.0852085378681845 no 326 0.110533375426859 157 2905394
SGTC_3034 9090421 49.47 µM 1.22204122243929 0.085477964988736 no 327 0.110846019315402 111 17173761
SGTC_185 k048-0037 25.491 µM 1.21963434546658 0.085870873033138 no 328 0.11130176022257 117 6827589
SGTC_38 0929-0051 58.268 µM 1.219057693992 0.0859652082856789 no 329 0.11141114778225 141 1379719
SGTC_3215 9129942 49.47 µM 1.21686208866846 0.0863251003622352 no 330 0.11182834601067 146 17682944
SGTC_2746 daunorubicin 9.88 µM 1.21639954116964 0.0864010621984215 no 331 0.111916379337171 93 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2935 9038016 29.96 µM 1.21621438075233 0.0864314841615512 no 332 0.111951633468589 140 6463195
SGTC_311 1315-0136 58 µM 1.21313043310178 0.0869393567527609 no 333 0.112539978101815 119 6759207
SGTC_3011 9081274 71.4286 µM 1.21151855652544 0.0872056903286015 no 334 0.112848363573491 133 6625322
SGTC_1998 st075797 76.8 µM 1.21136229873479 0.0872315414712022 no 335 0.112878290979812 145 24208315
SGTC_2859 9028643 45.46 µM 1.20723995725283 0.0879156060493399 no 336 0.113669873226937 105 17151580
SGTC_1281 0884-0031 11.8 µM 1.20722390971931 0.0879182767843589 no 337 0.113672962426943 145 1548255
SGTC_2077 5212015 200 µM 1.20199107029877 0.0887923902356539 no 338 0.11468349391672 133 780900
SGTC_2707 st078556 66.6 µM 1.19808030661174 0.0894498727022263 no 339 0.115442877379405 129 17250899
SGTC_2518 prenyletin 46.28 µM 1.19764583145524 0.0895231401157259 no 340 0.115527462829741 103 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2325 6158266 200 µM 1.19722739943549 0.089593744286157 no 341 0.11560896655149 131 3623240
SGTC_1169 aniline yellow 25.8 µM 1.19694092394765 0.0896421066302175 no 342 0.115664790848137 147 6051 A DNA damaging agent.
SGTC_2973 9094665 17.96 µM 1.19225358774943 0.0904361746113356 no 343 0.11658091352389 172 25237061 YIL048W NEO1
SGTC_3269 9137823 49.47 µM 1.19128173585706 0.0906014649256018 no 344 0.116771500721909 115 17682936
SGTC_232 clozapine 119 µM 1.18753117213848 0.0912414549187777 no 345 0.11750908421005 135 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_321 4534-3890 65.3 µM 1.18703132733641 0.0913270001143057 no 346 0.117607631914734 151 699746
SGTC_2372 9071633 200 µM 1.18627069739062 0.0914572910606796 no 347 0.117757707359094 136 21321366
SGTC_2477 5967686 25.23 µM 1.18382236865223 0.0918776092127302 no 348 0.118241692811012 141 776118
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.18366666489157 0.0919043880465548 no 349 0.118272519818076 138 5355888
SGTC_2130 NSC 7 2.4545 µM 1.18335736466867 0.091957600434549 no 350 0.118333773473263 144 21448
SGTC_1805 st050013 60.3 µM 1.18098089224917 0.0923672129722998 no 351 0.118805157038741 145 4037144
SGTC_1992 st073643 23.3 µM 1.17891230135387 0.0927248563819688 no 352 0.119216549428495 152 3161292
SGTC_2276 7947513 42.08 µM 1.17515684580882 0.0933767612751705 no 353 0.119965985765518 134 2105100
SGTC_3214 9129694 49.47 µM 1.17470203956558 0.0934559398042278 no 354 0.120056971557446 163 17158655
SGTC_2340 7987427 183.45 µM 1.17279257440127 0.0937889052853441 no 355 0.120439498319506 135 2239331
SGTC_2141 5621638 7.665 µM 1.17273517859581 0.0937989272932619 no 356 0.120451009803402 144 2856238
SGTC_3157 9099274 49.47 µM 1.16941257798102 0.094380442197723 no 357 0.121118722306574 145 17217662
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.16788329262081 0.0946489863247326 no 358 0.121426922122161 145 4213774
SGTC_2329 6138490 200 µM 1.16160538161015 0.095757296684524 no 359 0.122697897539149 145 720019
SGTC_213 1246-0773 967 nM 1.15819969482105 0.0963625210339804 no 360 0.123391276425301 128 6251622
SGTC_333 3486-0131 40.1 µM 1.15750579709295 0.0964861775278769 no 361 0.123532886109019 146 6744690
SGTC_2751 anetholtrithion 17.25 µM 1.15685982374262 0.0966013983780705 no 362 0.123664817720553 134 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1811 st050069 61.5 µM 1.15525561783973 0.0968879741818992 no 363 0.123992882446641 140 3877702
SGTC_2781 5567276 71.43 µM 1.15364337381534 0.0971766143160845 no 364 0.124323204129147 164 2853274
SGTC_1034 k072-0165 12.7 µM 1.1488972421697 0.0980299767624916 no 365 0.125299177484343 170 5835461
SGTC_1101 ebselen 5.29 µM 1.14738087204349 0.0983037767412492 no 366 0.12561212156954 171 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2430 5571206 200 µM 1.14600568853401 0.0985525675952859 no 367 0.125896399166461 162 1731771
SGTC_1353 1498-1206 8.11 µM 1.14515086172716 0.0987074504394687 no 368 0.126073334720963 149 6756808
SGTC_3060 1327-0027 12.5 µM 1.14482676798419 0.0987662183129286 no 369 0.126140462273532 151 16000455 YPR107C YTH1
SGTC_1001 4048-4355 44.4 µM 1.13933759028087 0.0997654625210332 no 370 0.12728118777004 166 21824233
SGTC_376 3970-0862 59.1 µM 1.1346272112022 0.10062880625745 no 371 0.128265773442109 181 3135186
SGTC_565 1418-0001 44.5 µM 1.13254490495969 0.101012194831727 no 372 0.128702708323717 153 2862145
SGTC_1432 4049-0298 68.4 µM 1.12982326020678 0.101514900514383 no 373 0.129275352479284 141 741646
SGTC_2566 crystal violet carbinol 226 nM 1.12832258034619 0.101792864054093 no 374 0.129591855310753 197 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2743 auranofin 4.32 µM 1.12454134212378 0.102495700078504 no 375 0.130391721101758 116 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1411 3909-8223 150 µM 1.12001493749325 0.103341675134457 no 376 0.131353698350412 170 X1411
SGTC_2426 5582046 32.21 µM 1.11844649631944 0.103635992663946 no 377 0.131688172740894 148 2251934
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.11802902555088 0.103714433321053 no 378 0.131777298478078 130 4000243
SGTC_939 1165-0479 45.3 µM 1.11306789845952 0.10464990331958 no 379 0.132839634718235 150 1377347
SGTC_2032 5185112 25.99 µM 1.11196313111454 0.104859047643218 no 380 0.133077001402822 141 5718189
SGTC_2820 7989630 71.43 µM 1.1073316358909 0.105739133249492 no 381 0.134075285650528 110 2984098
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.10710567554069 0.105782206875424 no 382 0.13412412100043 156 23847180
SGTC_2802 7925815 54.55 µM 1.10696621147175 0.105808798502264 no 383 0.13415426856596 158 1262923
SGTC_3025 9087895 49.47 µM 1.1037659139418 0.106420327668042 no 384 0.134847347266506 164 17173641
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.10160673536803 0.106834353709082 no 385 0.13531633944057 152 2724 A muscle relaxant with antifungal properties.
SGTC_1984 st072354 53.1 µM 1.1011754830136 0.106917186115716 no 386 0.135410144961107 161 5762938
SGTC_1744 st037937 38.9 µM 1.09357596462965 0.108384465439718 no 387 0.137070497733674 161 1016152
SGTC_3090 9117696 49.47 µM 1.09217769119776 0.108656008265896 no 388 0.13737750305898 149 7923821
SGTC_2104 5389443 200 µM 1.09052877106814 0.1089768546446 no 389 0.13774014335997 161 2244536
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.08681220310191 0.109702519333135 no 390 0.138559906783185 160 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_284 0988-0104 32.6 µM 1.08648031427868 0.109767489374877 no 391 0.138633272845682 178 4666532
SGTC_1658 st012944 20 µM 1.08599884450422 0.109861790241609 no 392 0.138739751731704 166 24207260
SGTC_2360 9040895 200 µM 1.08540898401478 0.109977399789946 no 393 0.13887027754693 149 4914414
SGTC_785 1270-0111 65.3 µM 1.08507993646364 0.110041929294408 no 394 0.138943126340427 162 6741994
SGTC_775 4577-0580 57.3 µM 1.08393291034743 0.11026708493347 no 395 0.139197273195942 166 2006902
SGTC_1381 2324-0066 62.1 µM 1.08379922747744 0.110293347711323 no 396 0.139226913913002 171 10885928
SGTC_1867 st057372 64 µM 1.08363615364908 0.110325390587186 no 397 0.139263077129505 148 688837
SGTC_652 0437-0092 114 µM 1.08356194927252 0.110339973442092 no 398 0.139279534791548 158 3091274
SGTC_2583 asiatic acid 100 µM 1.08032478695875 0.11097749575991 no 399 0.139998787818797 200 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3105 9121040 49.47 µM 1.07998774757318 0.111044023174394 no 400 0.140073818152518 142 41448907
SGTC_1059 3448-6867 171 µM 1.07631721476069 0.111770390914682 no 401 0.140892706120013 177 3934407
SGTC_522 1273-0010 11.6 µM 1.07560867426675 0.11191099559809 no 402 0.141051153183478 182 5705015
SGTC_1927 st060202 13.8 µM 1.07505031864501 0.112021886267317 no 403 0.141176100325016 165 688887
SGTC_2269 7935389 174.42 µM 1.07285020952316 0.112459597423772 no 404 0.141669164408226 165 97605
SGTC_1615 st002656 86.5 µM 1.07204155307412 0.112620786096352 no 405 0.141850684355923 148 1584458
SGTC_502 l-744,832 89.3 µM 1.07201411602715 0.112626257987851 no 406 0.141856845939429 160 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2753 fluvastatin 17.09 µM 1.07153642178847 0.112721557092826 no 407 0.141964151579785 172 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2944 9067346 25.62 µM 1.06919191572879 0.113190116466173 no 408 0.142491600378419 176 6473075
SGTC_3236 9132701 49.47 µM 1.06814145630642 0.113400505371494 no 409 0.142728354022249 167 24282524
SGTC_2196 6573537 42.6665 µM 1.06558051014251 0.11391458712652 no 410 0.143306656696952 178 2903087
SGTC_571 k831-0106 44.2 µM 1.06370027383689 0.11429307957382 no 411 0.143732250189024 179 4783639
SGTC_2532 xanthone 78.9 µM 1.06230912034812 0.114573695218179 no 412 0.14404768767331 144 7020 An insecticide.
SGTC_2065 5221596 34.26 µM 1.06197662564322 0.114640836720294 no 413 0.144123148348407 163 788581
SGTC_356 1634-0012 32.5 µM 1.06118966335108 0.114799861568388 no 414 0.144301857997649 188 735457
SGTC_637 1181-0519 7.26 µM 1.06075674518614 0.114887410082998 no 415 0.144400232152174 177 6252091 YGR060W ERG25
SGTC_870 0573-2213 57.6 µM 1.0552413834964 0.116006933414908 no 416 0.145657470894058 157 3916321
SGTC_93 0109-0045 59.227 µM 1.05287063493321 0.116490526792358 no 417 0.146200143114038 175 88733
SGTC_890 0929-0006 47.2 µM 1.05276839226416 0.116511414715661 no 418 0.146223577304781 155 1378169
SGTC_2919 7978188 46.38 µM 1.05195326216034 0.116678038788052 no 419 0.146410496712937 166 2980291
SGTC_1677 st019204 53.9 µM 1.05056160422742 0.116962903609484 no 420 0.146729991658132 154 3945625
SGTC_2561 acetosyringone 100 µM 1.05004322184218 0.117069139558089 no 421 0.146849120671752 191 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_454 lyso-paf C-16 6.67 µM 1.04948514329238 0.11718358714103 no 422 0.146977444730223 189 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_591 4299-0174 154 µM 1.04753883794001 0.117583344552441 no 423 0.147425564683091 175 5509088
SGTC_1773 st048542 73.5835 µM 1.04439231883944 0.118231657599782 no 424 0.14815195796834 206 3237138
SGTC_679 0422-0091 41.4 µM 1.0399462577772 0.119152032681425 no 425 0.149182434837249 200 627384 YHR062C RPP1
SGTC_3094 9117742 49.47 µM 1.03928273769942 0.11928981991667 no 426 0.14933663036072 212 17149698
SGTC_467 ro 31-8220 72.8 µM 1.03879591197775 0.119390986121885 no 427 0.149449831508633 176 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_766 1391-0721 126 µM 1.03695696777986 0.119773679361386 no 428 0.149877956250408 200 1020919 YIL115C NUP159
SGTC_489 paxilline 115 µM 1.03498780882316 0.120184429049348 no 429 0.150337302319441 167 105008 A toxic potassium channel blocker.
SGTC_3160 9100216 49.47 µM 1.03343680562787 0.12050865305072 no 430 0.150699764865913 174 17191039
SGTC_3323 9138564 53.9225 µM 1.03284843533093 0.120631807849507 no 431 0.150837416504707 174 43912313 YNL103W MET4
SGTC_756 0508-1999 28.3 µM 1.03248011003557 0.120708948986321 no 432 0.150923630301428 176 6753853
SGTC_221 trifluoperazine 10.304 µM 1.03096855362602 0.121025889267335 no 433 0.151277783313859 220 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_3139 9095020 49.47 µM 1.02957461827544 0.121318685491058 no 434 0.151604867606943 143 25236292
SGTC_2843 9000894 45.46 µM 1.02954501977615 0.121324908053956 no 435 0.151611817931913 116 2242070
SGTC_905 2-aminofluorene 215 µM 1.02914863291374 0.121408263035332 no 436 0.151704917978286 173 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3083 9117465 49.47 µM 1.02891725473881 0.121456937450833 no 437 0.151759279716241 173 16420915
SGTC_826 1683-5028 118 µM 1.02859219759723 0.121525342035173 no 438 0.151835672963904 154 722377
SGTC_1177 0983-0204 23.6 µM 1.02806239803887 0.121636890365376 no 439 0.151960238465523 186 766818
SGTC_381 3461-2219 42.7 µM 1.02771593827602 0.121709875739205 no 440 0.152041734151288 179 2883159
SGTC_1361 1608-0041 5.61 µM 1.02429387429127 0.122432422640818 no 441 0.152848245211231 193 X1361
SGTC_2866 9034245 58.44 µM 1.02377744337047 0.122541724601855 no 442 0.152970203426325 161 6462273
SGTC_2860 9025725 38.96 µM 1.02217459571768 0.122881401253777 no 443 0.153349136124817 179 40546248
SGTC_2369 9071472 200 µM 1.02171356059129 0.122979226304177 no 444 0.153458245503574 156 17296037
SGTC_462 ag-879 158 µM 1.01902480175327 0.12355083013188 no 445 0.154095596050824 196 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1567 st069303 68.4 µM 1.01849740742846 0.123663166936346 no 446 0.154220816137974 189 5581319
SGTC_1036 k216-0215 33.5 µM 1.01762537457687 0.123849069790859 no 447 0.154428011902162 159 622330
SGTC_2469 5655019 90.81 µM 1.01629964281132 0.124132068296988 no 448 0.154743359324503 171 2788239
SGTC_3260 9137109 49.47 µM 1.01137651350015 0.125186946655528 no 449 0.155918128918027 169 17478346
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.00962185816201 0.125564425223572 no 450 0.15633824661181 161 6312947
SGTC_2225 6654152 15.4 µM 1.00682500609077 0.126167751988545 no 451 0.157009437802983 183 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2363 9053361 176 µM 1.00487923056056 0.126588677697624 no 452 0.157477503251521 184 6469797 YMR079W SEC14
SGTC_673 1082-0474 110 µM 1.00222665464171 0.127164078227723 no 453 0.158117068538377 209 3098046
SGTC_3322 9139058 2.11 µM 1.00142982693278 0.127337282112039 no 454 0.158309525015597 179 4908926 YPR165W RHO1
SGTC_1443 4112-3303 14 µM 0.99684124670713 0.128337880063404 no 455 0.159420786910656 195 704433
SGTC_1597 7-benzyloxygramine 47.5 µM 0.995667896129766 0.128594618072633 no 456 0.159705766783811 205 260807
SGTC_2898 9056270 58.44 µM 0.993351980267883 0.129102403521885 no 457 0.160269227132413 130 19154699
SGTC_3284 9108171 64.8615 µM 0.992510015422346 0.129287356034303 no 458 0.160474398125764 181 8687505
SGTC_2710 st078562 53.7235 µM 0.991371714085433 0.129537695966343 no 459 0.160752053449329 186 17250908
SGTC_365 0121-0052 13.6 µM 0.989775864255195 0.129889226958337 no 460 0.161141842201457 167 3101739
SGTC_110 0850-0284 111.64 µM 0.989286441427093 0.129997168372131 no 461 0.161261507935989 157 3906265
SGTC_747 3448-8087 38.7 µM 0.987855010814582 0.130313224386946 no 462 0.16161183075733 175 5168703
SGTC_1828 st055811 49 µM 0.985706594890673 0.130788585804887 no 463 0.162138556160054 175 5877589
SGTC_2648 atorvastatin 78.68 µM 0.985249813255337 0.130889808239289 no 464 0.162250688891956 176 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2208 7283366 200 µM 0.985182438314733 0.130904743051039 no 465 0.162267232655525 204 898663
SGTC_1375 2910-0797 186 µM 0.984733577607333 0.131004270785606 no 466 0.162377477410462 193 742508
SGTC_2886 9058944 51.95 µM 0.983060157881468 0.131375785781186 no 467 0.162788915884067 135 4949929
SGTC_3250 9135583 49.47 µM 0.981177829988836 0.131794548954804 no 468 0.163252527484213 171 7699353
SGTC_616 4092-0450 108 µM 0.980552738454708 0.131933817099469 no 469 0.163406675180083 200 787165
SGTC_226 1,3-diallylurea 8.28947 mM 0.976587515896975 0.132819618476146 no 470 0.164386701036276 177 74537 YKL182W FAS1
SGTC_506 n9-isopropylolomoucine 153 µM 0.975783565813602 0.132999713169202 no 471 0.164585865222775 166 6610355
SGTC_661 1304-0007 33.6 µM 0.974454549865586 0.133297797565761 no 472 0.164915447799035 196 3117130
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.973536962428006 0.133503870882139 no 473 0.16514324948993 193 676296 Flavone; oxidizing agent.
SGTC_478 N-arachidonylglycine 10 µM 0.973331021869685 0.133550151446274 no 474 0.165194404588872 133 5283389
SGTC_704 1310-0270 142 µM 0.973202536487971 0.133579031269124 no 475 0.165226325218319 199 5718033
SGTC_1726 st035556 14.5795 µM 0.971598273975098 0.133939984982418 no 476 0.165625220776363 157 5919439
SGTC_1315 1237-0019 3.69 µM 0.96977179318137 0.134351752361716 no 477 0.166080127808181 185 825140
SGTC_324 1315-0088 19.6 µM 0.965065281592795 0.135416805496166 no 478 0.16725605753154 209 6787421
SGTC_92 0063-0024 660.874 µM 0.964343296232613 0.135580696600439 no 479 0.16743692040604 200 3594437
SGTC_940 3232-1287 54.8 µM 0.964285834497836 0.13559374628409 no 480 0.167451320423519 180 1585493 YIL048W NEO1
SGTC_3003 9075612 71.4286 µM 0.961187900225084 0.136298567841668 no 481 0.168228849549474 211 6501993
SGTC_1625 st003711 30.1 µM 0.956857200632465 0.137288054976858 no 482 0.169319668097219 185 24207034 YER133W GLC7
SGTC_1853 st056710 91.2 µM 0.9549171159924 0.137732916801349 no 483 0.169809806694918 201 269167
SGTC_3187 9109394 49.47 µM 0.95379915154647 0.137989712547832 no 484 0.170092659486189 214 17098090
SGTC_3261 9137475 49.47 µM 0.953790631192265 0.137991670921036 no 485 0.170094816353894 126 17027690
SGTC_1783 st039459 87.517 µM 0.949447006384723 0.138992506510347 no 486 0.171196656247495 205 729761
SGTC_862 0452-0056 10.2 µM 0.948716721845019 0.139161258960116 no 487 0.171382353469898 193 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1829 berberine 14.4 µM 0.947436217144524 0.139457491489444 no 488 0.171708271705979 209 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1465 k213-0056 144 µM 0.94710833312623 0.139533413251525 no 489 0.171791789442924 211 24048857 YMR208W ERG12
SGTC_3246 9135460 32.98 µM 0.945728061744427 0.139853324211883 no 490 0.172143652890953 192 41446951
SGTC_969 1313-0238 134 µM 0.945706666172068 0.139858287069013 no 491 0.172149110740204 225 5212874
SGTC_882 0843-0131 351 µM 0.945655905228398 0.139870061914433 no 492 0.172162059916158 219 5425421
SGTC_468 gf-109203x 121 µM 0.944798359473581 0.140069085763784 no 493 0.172380914790008 156 2396 A protein kinase C inhibitor.
SGTC_2289 7946404 165.07 µM 0.942497104494368 0.140604124066953 no 494 0.17296909643358 199 1246120 YPR165W RHO1
SGTC_977 1348-1378 135 µM 0.941009478223366 0.140950732204407 no 495 0.173350000994456 208 X977
SGTC_1324 1418-0026 34.4 µM 0.940976153020501 0.140958503411244 no 496 0.173358539975464 185 1372513
SGTC_495 decylubiquinone 155 µM 0.939117263158697 0.141392443940499 no 497 0.173835270924392 188 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2192 5915882 198.485 µM 0.938025773060635 0.14164766359489 no 498 0.174115582657854 190 2876149
SGTC_2382 9035899 200 µM 0.937664081127691 0.141732305667106 no 499 0.174208534148215 220 6462679
SGTC_2638 epoxomicin 18 µM 0.937329480822908 0.141810638335554 no 500 0.174294551415501 178 9915668 A protesome inhibitor.
SGTC_3178 9107506 49.47 µM 0.936731703905191 0.141950655767892 no 501 0.174448291887883 194 8897194
SGTC_1340 1486-1359 257 µM 0.93605700378439 0.142108803345299 no 502 0.17462191945705 207 4309068
SGTC_853 0419-0306 21 µM 0.931038733230044 0.14328881160764 no 503 0.17591676431069 222 762713
SGTC_981 1488-1094 54.9 µM 0.922576903395151 0.145293494741634 no 504 0.178113868295778 198 3449522
SGTC_1310 1188-0297 994 nM 0.92025506752068 0.145846841721578 no 505 0.17871974178504 189 1588352
SGTC_3039 9090270 49.47 µM 0.919805849579012 0.145954064013617 no 506 0.178837112990261 178 17173750
SGTC_422 cantharidin 155 µM 0.909433545461333 0.14844452600185 no 507 0.181560660676119 219 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3119 9125183 49.47 µM 0.908725438156106 0.148615577673684 no 508 0.181747536498571 168 22695334
SGTC_2282 7944268 200 µM 0.90574884985191 0.149336048396151 no 509 0.182534400040362 197 2970414
SGTC_779 1360-0071 233 µM 0.904952368711372 0.149529228120376 no 510 0.182745310788697 219 7566
SGTC_341 1486-1430 230 µM 0.904269785200815 0.149694915592739 no 511 0.182926182091181 240 2054753 YPL210C SRP72
SGTC_1875 nocodazole 6 µM 0.904118740347704 0.149731596134642 no 512 0.182966221118739 206 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3048 9093155 49.47 µM 0.904048818437287 0.149748578376391 no 513 0.182984757897145 190 25236002
SGTC_1245 0418-0076 17.2 µM 0.903932984692181 0.14977671425455 no 514 0.183015468796604 202 6790114
SGTC_2771 fluoxetine 41.05 µM 0.902733218813465 0.150068343361696 no 515 0.183333750810229 200 3386 A selective serotonin reuptake inhibitor.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.900278832408168 0.150666113822875 no 516 0.183985941465294 221 688788
SGTC_2693 st077581 40.7 µM 0.895918872251678 0.151731895532742 no 517 0.18514804697944 218 25238761
SGTC_3155 9099265 49.47 µM 0.894052348033249 0.152189690739258 no 518 0.185646941698834 203 25236499
SGTC_978 1416-0512 87.4 µM 0.893596188999965 0.152301710416611 no 519 0.185768993073446 202 6814003
SGTC_2175 5807670 165.306 µM 0.892445875311762 0.152584437712749 no 520 0.186076995644405 183 241186
SGTC_3309 9129340 25.759 µM 0.890648929325786 0.153026792522599 no 521 0.186558770491328 204 17158987
SGTC_1011 4112-3381 17.4 µM 0.889735079844095 0.153252080942477 no 522 0.186804076497038 205 2877139
SGTC_2861 9024595 19.48 µM 0.888267978473039 0.153614220200032 no 523 0.187198310033267 179 16482810
SGTC_3151 9099821 49.47 µM 0.887014911283614 0.153923975573108 no 524 0.187535436240322 221 17174189
SGTC_2180 6301957 200 µM 0.886950511366892 0.153939906246322 no 525 0.187552772576252 206 845462
SGTC_2670 beta-carotene 100 µM 0.885628804278116 0.154267099253246 no 526 0.18790879232436 174 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2268 7933382 153.85 µM 0.884437218107079 0.154562474323524 no 527 0.188230119664233 200 935025 YOR257W CDC31
SGTC_1190 1486-1332 13 µM 0.884408338705102 0.154569637699742 no 528 0.188237911591625 223 4150046
SGTC_1720 st037298 9.481 µM 0.882943223131941 0.154933339467732 no 529 0.188633474332776 212 597396
SGTC_1564 D-Arginine 115 µM 0.882914399103929 0.154940500438194 no 530 0.188641261593588 230 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_702 1488-0190 94 µM 0.881829073915873 0.155210295027375 no 531 0.188934623331761 184 949357
SGTC_1583 clindamycin 39.6 µM 0.881713732951299 0.155238985176079 no 532 0.188965816331856 222 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_816 0325-0417 81.3 µM 0.881358047652906 0.155327481109127 no 533 0.189062028424151 210 68101
SGTC_2339 9000433 200 µM 0.881083848965088 0.155395725567333 no 534 0.189136219158461 215 2988954
SGTC_2995 9067767 71.4286 µM 0.880470108622783 0.155548549186096 no 535 0.189302345628091 179 11673567
SGTC_274 sirtinol 40.1 µM 0.879747112572653 0.155728705028176 no 536 0.189498160491351 201 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1652 st011932 78 µM 0.879354662512137 0.155826553156373 no 537 0.189604503082905 217 1551076
SGTC_2932 9016711 44.54 µM 0.87883150481645 0.155957053158102 no 538 0.189746320733174 214 7117328
SGTC_1012 4112-3522 18 µM 0.877260895115087 0.156349269344428 no 539 0.190172473566835 204 3112398
SGTC_2852 9023854 51.95 µM 0.876478251973209 0.156544955068805 no 540 0.190385047143379 240 19798528
SGTC_3271 9137798 49.47 µM 0.876004284686172 0.156663540356759 no 541 0.190513852240793 183 6498326
SGTC_1965 Pectolinarigenin 58.4 µM 0.869769968165207 0.158228851639868 no 542 0.192213063310847 219 5320438 An anti-inflammatory.
SGTC_1480 1070-0044 41.2 µM 0.868637872353773 0.158514195402728 no 543 0.192522616403432 213 3124987
SGTC_873 0591-4978 488 µM 0.8685816399448 0.15852837752507 no 544 0.192538000176782 243 3305145
SGTC_9 0092-0002 10.449 µM 0.867431474013417 0.158818638267133 no 545 0.192852821503407 229 759368
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.867300912304874 0.158851609374846 no 546 0.192888578479569 222 165521
SGTC_485 niflumic acid 177 µM 0.86575510226767 0.159242318014784 no 547 0.19331223769554 215 4488 A COX2 inhibitor.
SGTC_3254 9136651 49.47 µM 0.863738738442572 0.159752905794327 no 548 0.193865713970546 236 16454030
SGTC_2041 5107442 45.335 µM 0.862338134219027 0.16010819938285 no 549 0.1942507368599 235 793005
SGTC_551 k048-0028 34.9 µM 0.859273236367588 0.16088747788308 no 550 0.195094893164008 225 6836383
SGTC_537 1334-0398 209 µM 0.855406723760633 0.161874100447654 no 551 0.196163011297875 224 5846986
SGTC_1414 3917-0015 5.4 µM 0.852588243557244 0.162595774146422 no 552 0.196943842198443 216 6618702
SGTC_577 r071-0003 38.6 µM 0.850330188061533 0.163175458685162 no 553 0.197570768712972 249 4568517 YMR134W ERG29
SGTC_2187 6125751 200 µM 0.850141768397291 0.163223890127345 no 554 0.197623136025434 225 874498
SGTC_3293 9120939 62.045 µM 0.850049191333858 0.163247689582886 no 555 0.197648868961235 221 934087
SGTC_1645 Cervolide 78 µM 0.849429879620766 0.163406958517115 no 556 0.197821066370073 224 23173 A fragrance.
SGTC_3136 9095672 49.47 µM 0.848288893148756 0.163700651182166 no 557 0.198138550812291 210 17217380
SGTC_3013 9080133 71.4286 µM 0.847445319390914 0.163918009289869 no 558 0.198373476557009 238 17050193
SGTC_1723 st034307 2.5525 µM 0.841604096779999 0.165428213873277 no 559 0.200004797684052 246 867466
SGTC_2248 tofa 1.1 µM 0.83928524847567 0.166030222863848 no 560 0.200654629573607 233 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1231 0242-0792 125 µM 0.838803161275031 0.166155557699347 no 561 0.200789888225719 217 3707635
SGTC_3277 9138724 49.47 µM 0.836847055275847 0.166664740414027 no 562 0.201339271870614 178 15943418
SGTC_283 0987-0079 11.7 µM 0.836328892242397 0.166799788979328 no 563 0.201484951759639 219 411556
SGTC_793 0488-0545 106 µM 0.835986833400809 0.166888978274424 no 564 0.201581155116651 233 292548
SGTC_1172 0370-0043 85 µM 0.833857978930939 0.167444752558153 no 565 0.202180509473489 206 376585
SGTC_1903 st060211 78.3 µM 0.833567073210637 0.167520791037017 no 566 0.202262493334185 218 688960
SGTC_2397 5161689 200 µM 0.832411394626719 0.167823088114269 no 567 0.202588386262552 235 2259942
SGTC_1812 st052057 4.327 µM 0.831085327216883 0.168170387139186 no 568 0.202962714024585 225 3645418
SGTC_2107 5363541 170.161 µM 0.827738923609819 0.169048869415854 no 569 0.203909185262459 225 244052
SGTC_1196 1588-0294 184 µM 0.826935764910988 0.169260148671434 no 570 0.204136735319366 222 6144269
SGTC_907 3448-6986 75.5 µM 0.825681758236804 0.169590366984082 no 571 0.204492321416083 230 590582
SGTC_367 0335-0881 7.1 µM 0.825089739706135 0.169746407092441 no 572 0.20466032218916 236 23828853
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.824515009093058 0.169897978627062 no 573 0.2048234955854 200 6708630 An antioxidant.
SGTC_1398 3558-0053 112 µM 0.824420465418225 0.169922920582112 no 574 0.204850345156236 213 4532369
SGTC_2073 5212005 126 µM 0.823334964668706 0.170209459180796 no 575 0.205158767745656 241 691789
SGTC_1818 st052136 56.3 µM 0.823139649601078 0.170261049158308 no 576 0.205214291760133 232 674169
SGTC_2659 sanguinarine 24.21 µM 0.821134519327227 0.170791257914336 no 577 0.205784824771641 240 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_686 1319-0111 510 µM 0.816601133897326 0.171993893754071 no 578 0.207078203445997 268 4562600
SGTC_1642 st009582 77.7 µM 0.816021807720703 0.172147968527654 no 579 0.207243831546597 250 6739311
SGTC_527 4476-4215 268 µM 0.815016322473313 0.172415591540738 no 580 0.207531483518099 203 4418754
SGTC_728 3030-5151 22.5 µM 0.814196022853141 0.172634121440604 no 581 0.20776633175687 232 3125388
SGTC_828 2074-0507 139 µM 0.813758402387146 0.172750776846183 no 582 0.207891684791243 230 X828
SGTC_2783 7738165 71.43 µM 0.812095444150156 0.173194525626905 no 583 0.208368433579237 242 17201110
SGTC_1988 st071872 53.4 µM 0.811543551352803 0.173341954651816 no 584 0.208526796574088 212 16414116
SGTC_740 k014-0057 261 µM 0.811120232344335 0.173455091445876 no 585 0.208648314014726 239 4012779
SGTC_717 1532-0246 73.2 µM 0.809347707664966 0.173929328991261 no 586 0.209157585915714 219 9561992
SGTC_1758 st042942 75.2445 µM 0.808681131639075 0.174107883992888 no 587 0.209349292020538 244 669317
SGTC_2322 7413319 38.22 µM 0.808482695656771 0.174161061323728 no 588 0.209406381831088 232 1840400
SGTC_1020 4335-0961 93.3 µM 0.80843102544031 0.174174909720907 no 589 0.209421248797771 243 669075
SGTC_3208 9114115 49.47 µM 0.808217158542753 0.174232236717451 no 590 0.209482790891698 240 650895
SGTC_1129 3453-1384 223 µM 0.807913787692728 0.174313575802917 no 591 0.209570106788973 245 1084452
SGTC_2741 miltefosine 3.04 µM 0.803912100195872 0.175388756279624 no 592 0.210723870675424 218 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2847 9005661 71.43 µM 0.80297793705282 0.175640352910535 no 593 0.210993743438286 203 2991449
SGTC_3315 9136395 68.55 µM 0.797896633842901 0.177012894223019 no 594 0.212465238484741 267 16876844
SGTC_2515 chrysin 20.77 µM 0.796827177100518 0.177302632583791 no 595 0.212775704525673 223 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2997 9067075 71.4286 µM 0.795227571707412 0.177736557975305 no 596 0.213240568059019 248 27209819
SGTC_2056 5235370 200 µM 0.79403451561953 0.178060634450668 no 597 0.213587668999466 228 5511916
SGTC_2955 9076254 12.21 µM 0.792223565794921 0.178553264270793 no 598 0.214115165024634 221 16459619
SGTC_1967 st070177 51.4 µM 0.791863934012201 0.178651196400772 no 599 0.214220009230656 238 5729214
SGTC_1159 4092-0538 61.2 µM 0.791380977999172 0.178782764424072 no 600 0.214360853384318 264 717301
SGTC_1317 1273-0028 910 nM 0.789033749225788 0.179423070343555 no 601 0.215046140712652 244 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1572 epiandrosterone 68.9 µM 0.784316581379436 0.180714231023172 no 602 0.216427186173286 222 441302 A steroid.
SGTC_1420 4'-methoxyflavone 42 µM 0.782907263072161 0.181101110339839 no 603 0.216840786043324 240 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.782864480481158 0.181112862920909 no 604 0.21685334881222 233 88881 An O-methylated flavonoid and antioxidant.
SGTC_1797 st048695 56.8 µM 0.782347612487862 0.181254886767219 no 605 0.217005156249891 266 592262 YIL048W NEO1
SGTC_409 arachidonic acid 100 µM 0.781719756058986 0.181427501564435 no 606 0.217189644290833 242 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2557 derrustone 83.84 µM 0.781039866599298 0.181614537673031 no 607 0.217389523749901 271 629853 An antioxidant.
SGTC_1156 4092-0367 4.88 µM 0.78064195383229 0.181724058562893 no 608 0.217506554650028 253 1357585
SGTC_1841 st054148 70 µM 0.780573864729331 0.181742803440934 no 609 0.217526584112192 248 675442
SGTC_1239 0337-0584 35.4 µM 0.780346466162237 0.181805414858445 no 610 0.217593484630263 254 914301 YML130C ERO1
SGTC_1301 naphtanilide LB 4.81 µM 0.775157556569832 0.183237782743796 no 611 0.219123282331507 258 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3126 9127922 49.47 µM 0.774685680059829 0.183368389668236 no 612 0.219262707359888 279 45595682
SGTC_1557 sumaresinolic acid 42.3 µM 0.774219694782169 0.183497422949142 no 613 0.219400441736237 234 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1405 3909-7894 12 µM 0.774149594520712 0.183516838902181 no 614 0.219421166039008 248 7104060
SGTC_1521 st012942 49.4 µM 0.773955298807779 0.183570660464546 no 615 0.219478613118253 231 24207259
SGTC_1850 st056238 17 µM 0.77199112738911 0.184115304874625 no 616 0.220059841273308 261 5393177
SGTC_987 1497-1013 404 µM 0.768116283272165 0.185192704903899 no 617 0.221209051896109 244 1676435
SGTC_2745 rifampicin 24.3 µM 0.766943255962606 0.185519635590456 no 618 0.221557626960498 201 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_544 k015-0020 52.4 µM 0.76593587076192 0.18580068640241 no 619 0.221857230477273 254 3008304
SGTC_1284 0929-0043 16 µM 0.765262377491341 0.185988731785022 no 620 0.222057661157738 251 1239883
SGTC_1255 0566-0045 221 µM 0.763833964282437 0.186387947956153 no 621 0.222483096909399 243 2788469
SGTC_2384 9036245 200 µM 0.762840884528542 0.186665808711408 no 622 0.222779147518033 220 6462766
SGTC_211 3455-0679 143.504 µM 0.762218822755334 0.186839990302879 no 623 0.222964706904381 221 748649
SGTC_801 0866-0028 10.1 µM 0.761864036530194 0.186939377924789 no 624 0.223070578110605 250 6849771
SGTC_1406 3909-7906 11.9 µM 0.759327648350308 0.187650858546853 no 625 0.223828291127039 251 X1406
SGTC_1021 4476-0760 85.3 µM 0.759155740713198 0.187699140706386 no 626 0.223879699179865 221 746768
SGTC_2084 5306078 60.6385 µM 0.759005163867108 0.187741438181738 no 627 0.223924733886857 271 679340
SGTC_2402 5553605 200 µM 0.758973300336327 0.187750389495173 no 628 0.223934264330413 257 6758546
SGTC_595 3909-8003 73.7 µM 0.755525636595433 0.188720486855251 no 629 0.224966827992229 260 699517
SGTC_975 1335-0046 28.5 µM 0.752791651401512 0.189491962859272 no 630 0.225787562191037 264 16486740
SGTC_2257 7960413 200 µM 0.752575489492385 0.18955304210451 no 631 0.225852525516923 248 2974689 YIL048W NEO1
SGTC_1133 3473-0247 50 µM 0.752240856856474 0.189647620619695 no 632 0.225953113797551 244 711311
SGTC_2068 5226020 147 µM 0.751711851914631 0.189797194536453 no 633 0.226112180721121 268 1810509
SGTC_3179 9107801 49.47 µM 0.751291792612478 0.189916016189707 no 634 0.226238533757632 235 4818259
SGTC_609 0986-0026 86.3 µM 0.751262531951841 0.189924294819874 no 635 0.226247336794433 258 2848610
SGTC_545 4218-0007 221 µM 0.749809861091656 0.19033557346103 no 636 0.22668461440194 261 2840508
SGTC_279 1273-0055 2.93 µM 0.749549029519917 0.190409477707714 no 637 0.226763179433567 269 2847562
SGTC_493 zm226600 134 µM 0.749255633756362 0.190492629778304 no 638 0.226851571477457 276 5240098 A potassium channel opener. YCR052W RSC6
SGTC_282 k297-0036 65.7 µM 0.748597114831467 0.190679343537708 no 639 0.22705003580264 264 5061378
SGTC_1207 2099-0101 141 µM 0.748113332611778 0.190816584712828 no 640 0.227195900365307 259 5837381
SGTC_1350 1495-0454 146 µM 0.748022650662948 0.190842316455554 no 641 0.22722324764123 243 1069057
SGTC_3111 9122088 49.47 µM 0.74723087033318 0.191067081020542 no 642 0.227462106436057 250 16876704
SGTC_713 1488-1073 324 µM 0.745668322937353 0.191511121109941 no 643 0.227933899580425 266 3312542
SGTC_2444 5485484 36.41 µM 0.745059997209631 0.191684164155597 no 644 0.228117725288373 270 6790631
SGTC_2603 homopterocarpin 100 µM 0.744066848917827 0.191966878708626 no 645 0.228418016915546 258 101795 A weak amylase inhibitor.
SGTC_2154 5570129 200 µM 0.743136763437718 0.192231872769802 no 646 0.228699441955335 280 673366
SGTC_261 5-fluorouridine 15.376 µM 0.742066721661286 0.192537018936013 no 647 0.229023455636742 234 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2008 4012253 172 µM 0.741260401024703 0.192767154674524 no 648 0.229267783374372 246 603940
SGTC_948 3448-0295 75.3 µM 0.739927704454203 0.19314789408415 no 649 0.229671931445352 253 678569
SGTC_1175 0741-0056 27.6 µM 0.739474737060254 0.19327740725236 no 650 0.229809387279565 264 765927
SGTC_3231 9132313 49.47 µM 0.73889326490684 0.193443740373749 no 651 0.229985906196733 252 4905967
SGTC_1230 0170-0365 3.77 µM 0.738587336246837 0.193531287900347 no 652 0.230078808160742 257 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_876 0720-0963 56.8 µM 0.736113854923245 0.194240010669304 no 653 0.23083070586273 252 765861
SGTC_2915 7971052 15.16 µM 0.734881374782225 0.194593740526047 no 654 0.231205871211949 228 5741558
SGTC_2050 5263056 171 µM 0.734876928689434 0.194595017292929 no 655 0.231207225212348 245 763468 YGL055W OLE1
SGTC_2716 st080858 38.6235 µM 0.73477197562762 0.194625157729025 no 656 0.231239188602774 250 5296050
SGTC_1771 st048882 4.1505 µM 0.734356764310212 0.194744426023807 no 657 0.231365665118675 253 4580403
SGTC_2828 7998861 71.43 µM 0.733616343554292 0.194957220129422 no 658 0.231591298604634 205 2988188
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.733493961833342 0.194992405780262 no 659 0.231628604632022 268 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1370 2001-0092 44.6 µM 0.733399281335032 0.195019629773249 no 660 0.231657468701212 261 790957
SGTC_687 k029-0044 34.9 µM 0.730841940069622 0.195755829706896 no 661 0.232437851428722 239 5829338
SGTC_3352 9151559 45.5865 µM 0.72981178799085 0.196052862858807 no 662 0.232752619001294 248 17159339
SGTC_2311 7694451 200 µM 0.728666663883052 0.196383367603065 no 663 0.233102794627607 274 2163142
SGTC_505 gw-5074 63.9 µM 0.728128243949705 0.196538882557364 no 664 0.233267542924637 265 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1218 1348-1416 30.7 µM 0.727882874667182 0.196609778735563 no 665 0.233342643616387 258 6787668
SGTC_1834 st055981 52.8 µM 0.72704057918338 0.196853266621643 no 666 0.233600548810927 253 471719 YDL150W RPC53
SGTC_2441 5730946 39.09 µM 0.726274111593946 0.197074993029411 no 667 0.233835373309373 253 1774275
SGTC_459 nigericin 15.3 µM 0.725556742570808 0.197282652901758 no 668 0.234055273824 281 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1448 4255-0083 152 µM 0.725519246950463 0.197293510557719 no 669 0.234066770786973 271 5399660
SGTC_1697 st025554 27.742 µM 0.725056768550593 0.19742746075668 no 670 0.234208602320312 259 1269519
SGTC_465 cgp-37157 41 µM 0.724362587162145 0.197628623580491 no 671 0.234421581133396 239 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1490 4089-0339 670 nM 0.723416085386504 0.197903104413139 no 672 0.234712145873829 262 742542
SGTC_2194 5927483 104.545 µM 0.723234545879569 0.197955776279955 no 673 0.234767899085053 228 760979
SGTC_750 4073-0104 132 µM 0.721571117683414 0.198438797418071 no 674 0.235279100880969 247 22330957
SGTC_802 4112-3352 742 µM 0.71968242548187 0.198988091238549 no 675 0.235860274671403 237 704594
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.719553764069729 0.199025543514391 no 676 0.23589989413914 256 521171
SGTC_1806 st050005 60.3 µM 0.71792934172072 0.199498764714354 no 677 0.236400427503079 238 5194765
SGTC_169 k015-0017 16.025 µM 0.717608124373895 0.199592420800066 no 678 0.236499473412538 311 1840002
SGTC_797 k781-0471 270 µM 0.717377610744211 0.199659647061771 no 679 0.236570565315638 261 23738129
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.715620948102207 0.200172401948145 no 680 0.237112717560894 259 94937 An inhibitor of serotonin biosynthesis.
SGTC_1519 esterone 74 µM 0.715455846221747 0.200220634436041 no 681 0.237163707411645 271 698 A steroid.
SGTC_299 1273-0059 1.44 µM 0.714810463724097 0.200409242010158 no 682 0.237363084291909 259 2848077
SGTC_1270 0831-1170 17.3 µM 0.711300803098915 0.201436777516238 no 683 0.238448927017539 265 6764716
SGTC_2544 sphondin 68.51 µM 0.711109183609088 0.201492969366239 no 684 0.23850828975871 252 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1665 st014639 11.4 µM 0.708719954994223 0.202194391986713 no 685 0.239249139508934 266 981133 YIL048W NEO1
SGTC_2980 9014342 25.29 µM 0.707604174034307 0.202522459419267 no 686 0.239595550026019 270 2996599
SGTC_415 dibenzyl ketone 100 µM 0.706899821622716 0.20272972034339 no 687 0.239814367422897 282 7593
SGTC_151 3013-0144 2.285 µM 0.706438401263649 0.202865565393473 no 688 0.239957773501318 280 906558 YHR107C CDC12
SGTC_3152 9099253 49.47 µM 0.706300063704674 0.202906303431626 no 689 0.240000776914892 269 25236131
SGTC_2421 5690543 90.72 µM 0.704887356624526 0.203322601102128 no 690 0.240440169480688 275 3397993
SGTC_1922 5578187 25 µM 0.704792957293261 0.203350436928386 no 691 0.240469545998233 242 1350412
SGTC_1120 ficusin 1.78878 µM 0.704695276964417 0.203379242626379 no 692 0.24049994560058 276 6199 A DNA cross-linker.
SGTC_1824 st053723 68.6 µM 0.704024027373806 0.203577258385646 no 693 0.240708905263607 270 675225
SGTC_442 cape 100 µM 0.703548671780057 0.203717555771163 no 694 0.240856942966633 256 5281787
SGTC_872 0588-0139 234 µM 0.703124161781442 0.203842895200029 no 695 0.240989187927212 251 2047100
SGTC_1319 1306-0155 43.7 µM 0.703084552634322 0.203854592410734 no 696 0.241001529132386 281 3122360
SGTC_2378 9074213 121.43 µM 0.702157288199703 0.204128542627865 no 697 0.241290539381957 268 657714
SGTC_1985 st071382 65.5 µM 0.702154395520165 0.20412939758161 no 698 0.241291441268367 276 6123237
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.70215099297676 0.204130403232282 no 699 0.241292502123674 289 688801
SGTC_1264 0783-0040 158 µM 0.699142216322963 0.205020827374519 no 700 0.242231578947414 268 2855798
SGTC_1762 st045503 25.4615 µM 0.69873359866321 0.205141932420383 no 701 0.242359266242219 267 4645554
SGTC_2572 astragaloside iv 100 µM 0.698445616229184 0.205227309442034 no 702 0.242449278623488 267 45006101 An anti-inflammatory agent.
SGTC_3312 9133330 71.43 µM 0.696020494635682 0.205947112774126 no 703 0.243207997496764 286 17617324
SGTC_849 0386-0493 241 µM 0.695498673294812 0.20610219075838 no 704 0.243371421166904 279 726119
SGTC_819 1013-0258 27.7 µM 0.69545122218098 0.206116295997518 no 705 0.24338628481882 269 5753198
SGTC_2201 6605497 169.863 µM 0.693808054692789 0.206605094230737 no 706 0.243901295321799 268 670741
SGTC_1651 st011928 86.1 µM 0.689926650346714 0.207762430534052 no 707 0.245120157710959 270 720198
SGTC_2450 5739737 12.93 µM 0.686686440873988 0.208731505076132 no 708 0.246140171622548 276 2262825
SGTC_2460 5552655 174.22 µM 0.685828289113124 0.208988604659167 no 709 0.246410697518234 273 5401989
SGTC_1306 1185-0270 9.02 µM 0.684801182360846 0.20929656771767 no 710 0.246734694581009 277 1548076
SGTC_685 1278-0033 54.9 µM 0.684740930613092 0.209314641620097 no 711 0.246753707854635 286 3590572
SGTC_2996 9066192 71.4286 µM 0.682266349904132 0.210057742510411 no 712 0.247535273361141 268 6472854
SGTC_2801 7907800 81.82 µM 0.679980657398883 0.210745496514204 no 713 0.248258354224173 285 6620925
SGTC_3311 9131146 2.8755 µM 0.679720453602574 0.210823874253709 no 714 0.248340741271532 276 4900406 YPR165W RHO1
SGTC_1475 4092-1048 11.7 µM 0.678919660807993 0.211065193687375 no 715 0.248594383775909 282 2881759
SGTC_3292 9120825 59.784 µM 0.676741062932858 0.211722534430899 no 716 0.249285129057183 282 24824900
SGTC_1633 st005664 67.9 µM 0.675703551853144 0.212035999711419 no 717 0.249614440214008 283 2063822
SGTC_3010 9080089 71.4286 µM 0.675611650748168 0.212063779053602 no 718 0.249643621217215 262 17027233
SGTC_2641 levomentholum 100 µM 0.674388424556157 0.212433731530755 no 719 0.250032200014837 276 16666
SGTC_2292 7671323 168.05 µM 0.672894415692355 0.212886090635902 no 720 0.250507232567283 298 937504
SGTC_327 1273-0057 3.96 µM 0.672611146569586 0.212971922806327 no 721 0.250597354244139 279 3108138
SGTC_1166 k206-0078 225 µM 0.671993110763089 0.213159261278643 no 722 0.250794041075843 269 5404595
SGTC_825 1988-2224 89.6 µM 0.671664144390945 0.213259016459862 no 723 0.250898766314437 280 1180859
SGTC_3020 9089140 49.47 µM 0.669146624061117 0.214023325680403 no 724 0.251700975442267 276 17217859
SGTC_3188 9110789 49.47 µM 0.669041921264527 0.214055147531616 no 725 0.251734368356265 286 849217
SGTC_587 k089-0003 57 µM 0.667911436472977 0.214398906039371 no 726 0.252095063361727 285 9659696
SGTC_15 0266-0086 27.098 µM 0.667390254800856 0.214557495340817 no 727 0.252261444524009 298 1712902 YIL048W NEO1
SGTC_33 0986-0033 35.816 µM 0.667268086456797 0.214594679559006 no 728 0.25230045371631 247 2848082
SGTC_2483 5729050 27.16 µM 0.665250316865582 0.215209367070004 no 729 0.252945201191082 289 2865180
SGTC_2161 5662504 8.5105 µM 0.665139368634263 0.215243195634207 no 730 0.252980678137367 269 2859334
SGTC_59 0330-0160 1.33 µM 0.665013532514348 0.21528156731062 no 731 0.253020918822373 298 4293482
SGTC_2855 9016525 58.44 µM 0.664470782858329 0.215447115462134 no 732 0.253194521385527 289 43811474
SGTC_491 tetrandrine 80.3 µM 0.663559464090433 0.215725249680558 no 733 0.253486154382267 289 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_386 1509-0011 3.07 µM 0.661633407561759 0.216313765909726 no 734 0.254103095942808 270 3107280
SGTC_2764 methyldopa 94.69 µM 0.658575143315548 0.217250140820565 no 735 0.255084314489127 304 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2763 lisinopril 49.32 µM 0.654898735646275 0.218378870762112 no 736 0.256266477169861 288 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_250 brefeldin a 552.239 µM 0.653753291686447 0.218731233703283 no 737 0.256635381649636 282 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1048 3161-0300 24.5 µM 0.653638371493197 0.218766603652636 no 738 0.25667240838622 278 2165101
SGTC_2698 st077697 67.5 µM 0.651240326029649 0.21950542074273 no 739 0.257445681321204 283 3154499
SGTC_1798 st045719 60.953 µM 0.64877740330263 0.22026571578266 no 740 0.258241132586463 280 3980186
SGTC_161 4065-0411 162.148 µM 0.646433006238858 0.220990823039558 no 741 0.258999485312637 290 1906281 YLR208W SEC13
SGTC_973 1325-0077 65.9 µM 0.645854734590326 0.221169888655569 no 742 0.259186718390509 286 2835149
SGTC_2598 perillyl alcohol 100 µM 0.645153865488318 0.221387028610771 no 743 0.259413739882959 291 10819 An apoptosis inducer.
SGTC_3164 9100705 49.47 µM 0.645004695277635 0.221433259549225 no 744 0.25946207149474 260 17174235
SGTC_2499 avocadenofuran 51.48 µM 0.644451259844764 0.221604828874397 no 745 0.259641426922981 295 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3334 9142812 21.919 µM 0.644226968793104 0.221674382487364 no 746 0.259714132606898 289 45283678
SGTC_925 2064-1272 59.6 µM 0.643102624939939 0.222023234253871 no 747 0.260078755683598 295 6815817
SGTC_1987 st072290 61.9 µM 0.642669556233172 0.222157686663923 no 748 0.260219269608155 300 54697379
SGTC_1854 st056233 32.9 µM 0.642354686561629 0.22225547165167 no 749 0.260321457108388 304 5393174
SGTC_770 0389-1121 67.2 µM 0.642351844974035 0.222256354238455 no 750 0.260322379408613 293 6753108
SGTC_1739 st037196 92.5 µM 0.642148515351445 0.222319512871588 no 751 0.260388378913323 299 612214
SGTC_971 1315-0384 26.7 µM 0.641167738730517 0.222624307339387 no 752 0.260706853791151 313 6769120
SGTC_1794 st048918 76.9 µM 0.640722405394452 0.222762781506676 no 753 0.260851527256639 270 672303
SGTC_2772 vinpocetine 57.06 µM 0.639362993811147 0.223185787192696 no 754 0.261293408567455 320 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2156 5649887 115 µM 0.638923023233244 0.223322789939658 no 755 0.261436504809565 305 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3086 9117350 49.47 µM 0.636542876446384 0.224064774772215 no 756 0.262211321992864 264 2679265
SGTC_1721 st082152 9.2685 µM 0.636055023471848 0.224217030368226 no 757 0.262370279571057 302 5296051
SGTC_1830 st055982 50.3 µM 0.635158834316696 0.22449687793729 no 758 0.262662414232175 327 455313 An antimicrobial agent.
SGTC_268 camptothecin 39.6153 µM 0.634667101479694 0.224650512547015 no 759 0.262822777197161 299 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_456 gingerol 170 µM 0.633299407978866 0.225078141504068 no 760 0.263269069917569 319 442793 A herb.
SGTC_216 k038-0035 28.382 µM 0.633253979493416 0.225092353280449 no 761 0.263283900347146 299 4444231 YPR107C YTH1
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.632280677845555 0.225396961560669 no 762 0.263601743569425 286 803109
SGTC_2954 9074818 52.69 µM 0.631529141586994 0.225632324869197 no 763 0.263847300545352 306 16648742
SGTC_142 0335-0849 62.6745 µM 0.631483075118919 0.225646756314941 no 764 0.263862356096888 284 3889043 YPR107C YTH1
SGTC_1749 st037932 54.2 µM 0.629733960103131 0.226195095536222 no 765 0.264434329831899 322 594497
SGTC_573 3702-0553 84.7 µM 0.629509927766797 0.226265382959317 no 766 0.26450763564926 283 1222756
SGTC_1800 st050079 29.0735 µM 0.628950241602135 0.226441031598515 no 767 0.264690816224371 292 3645560
SGTC_646 4092-0839 27.3 µM 0.626676179350364 0.227155501484153 no 768 0.265435760689396 312 877796
SGTC_1626 st003712 1.76 µM 0.62637073781094 0.227251562485558 no 769 0.265535899170829 305 24207035
SGTC_2591 skatole 100 µM 0.624869200652714 0.227724126886878 no 770 0.266028454043596 315 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_874 0599-0792 117 µM 0.624219071462447 0.22792890728459 no 771 0.26624186183831 301 765305
SGTC_254 nsc-64875 3.808 µM 0.623694848694743 0.228094104572534 no 772 0.266414003377206 291 56993
SGTC_964 1287-0107 19.4 µM 0.622429104730639 0.22849325339459 no 773 0.266829873769507 286 51516812 YPR165W RHO1
SGTC_2 0422-0095 29 µM 0.621886011733589 0.228664636482899 no 774 0.267008411868144 260 6790840
SGTC_1636 st007707 68.9 µM 0.620176626441574 0.229204535667931 no 775 0.267570754061106 324 403051
SGTC_2014 4013930 200 µM 0.618400863123466 0.229766156190401 no 776 0.268155564500168 304 64556
SGTC_1666 st014829 29 µM 0.616640572671246 0.230323642858075 no 777 0.268735913457091 297 3858230
SGTC_708 3448-5400 146 µM 0.614567895744823 0.230981031324968 no 778 0.269420060808877 305 3462195
SGTC_149 3970-0822 46.1 µM 0.614156880989503 0.231111516722091 no 779 0.269555831858051 309 3114250 YBL034C STU1
SGTC_178 4092-0806 87.505 µM 0.612635090615369 0.231594999464375 no 780 0.270058825176855 278 2169044
SGTC_1327 1436-0082 2.18 µM 0.612265091070694 0.231712635875194 no 781 0.27018119107011 297 15992205
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.611454082283556 0.231970601713795 no 782 0.270449504084133 300 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_353 1988-1175 58.3 µM 0.610971369300081 0.232124219043834 no 783 0.270609267361393 313 2788357
SGTC_1741 st038134 10.228 µM 0.610382328777094 0.232311750457354 no 784 0.270804285648007 314 1272587
SGTC_561 1550-0330 72.9 µM 0.610352347313141 0.232321297837642 no 785 0.270814213723437 306 6812934
SGTC_2045 5106652 78.05 µM 0.608606187420576 0.232877726253238 no 786 0.271392751130653 290 673349
SGTC_3002 9075603 71.4286 µM 0.608566089241788 0.232890512562344 no 787 0.271406043682134 306 20105405
SGTC_163 TUB2.036 7.546 µM 0.608032741046172 0.233060621086916 no 788 0.27158287952416 298 15992207 YJR013W GPI14
SGTC_490 phenamil 164 µM 0.607687415747101 0.233170797511481 no 789 0.271697405469577 297 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1661 st013063 9.66 µM 0.607195296715924 0.233327858590278 no 790 0.271860656581666 319 721395
SGTC_1031 k035-0009 16 µM 0.606651006907823 0.233501638457688 no 791 0.272041271175168 308 5180959
SGTC_1236 0330-0013 258 µM 0.606437834613161 0.233569719281677 no 792 0.272112025533202 310 4617066
SGTC_319 1348-1596 45.5 µM 0.605004589818086 0.234027740280105 no 793 0.272587973511691 326 5380505
SGTC_3129 9127257 49.47 µM 0.603231484269445 0.23459505809755 no 794 0.273177352793093 316 837894
SGTC_234 nsc-17383 10.7 µM 0.602826352537484 0.234724789565526 no 795 0.27331210691553 298 408974
SGTC_791 1348-1292 225 µM 0.602271991178863 0.23490237166675 no 796 0.273496550834006 303 5437054
SGTC_1076 itraconazole 331 nM 0.601646771367381 0.235102741364216 no 797 0.27370464427083 306 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1124 fisetin 1.16336 µM 0.60158120168806 0.235123760524683 no 798 0.27372647252418 308 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2928 9011484 9.79 µM 0.601184432961396 0.235250971719198 no 799 0.273858575848261 300 2994751
SGTC_3237 9133362 49.47 µM 0.599622919154291 0.235751990035799 no 800 0.274378784577595 317 43845137
SGTC_3286 9117135 37.221 µM 0.598782893462509 0.236021759040981 no 801 0.274658835615086 299 3438150
SGTC_666 0272-0154 136 µM 0.597977425999825 0.236280589551988 no 802 0.274927497820764 304 6870312
SGTC_2488 5268135 45.7 µM 0.596312224149271 0.236816184050469 no 803 0.275483333132261 316 1270356 YLR208W SEC13
SGTC_2217 6934799 96.0675 µM 0.596174124534386 0.236860632284428 no 804 0.275529454842476 302 675606
SGTC_1217 1183-1422 255 µM 0.594202172627779 0.237495817580456 no 805 0.27618844990546 307 2849664
SGTC_1529 apigenin 74 µM 0.593188660981845 0.237822643156984 no 806 0.27652745013068 313 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2546 rhodinyl acetate 100 µM 0.591406707030941 0.238397864768341 no 807 0.277123973771983 292 6708682
SGTC_608 k048-0125 159 µM 0.590516146316262 0.238685626475383 no 808 0.277422332044823 294 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_865 0488-0499 301 µM 0.588599386920527 0.23930562204506 no 809 0.278065022634986 288 9634651
SGTC_2844 9010103 25.97 µM 0.586156992240314 0.240096912842622 no 810 0.278885010054856 331 2480525
SGTC_3252 9135871 49.47 µM 0.585427320202854 0.240333589532977 no 811 0.279130211573251 321 17682838
SGTC_2063 5246145 200 µM 0.585325875817833 0.240366504131854 no 812 0.279164309592745 325 711240
SGTC_305 1682-2595 20.8 µM 0.585207811449777 0.240404814334659 no 813 0.279203996557697 314 226033
SGTC_2003 4023581 200 µM 0.584837311439906 0.240525057893116 no 814 0.279328556770469 315 16641307
SGTC_631 k072-0230 41.5 µM 0.584227547207176 0.240723024501327 no 815 0.279533615157806 306 5773147
SGTC_2374 9071832 200 µM 0.583485725697861 0.240963984458301 no 816 0.279783181761056 299 17381698
SGTC_3024 9090631 49.47 µM 0.58126828034885 0.241685041015148 no 817 0.28052982756388 289 25236383
SGTC_622 1348-1566 26.3 µM 0.580784663061668 0.241842456432137 no 818 0.280692796473631 325 7340407
SGTC_398 bronopol 33.3 µM 0.57904623769009 0.242408765793301 no 819 0.281278987337057 299 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1968 st069590 43.6 µM 0.578761483108223 0.2425015958627 no 820 0.281375061874106 312 6384066
SGTC_1479 0549-0158 134 µM 0.577495032689469 0.242914692189625 no 821 0.281802546618216 283 5440202
SGTC_2667 digitoxin 100 µM 0.576956066235181 0.243090610043691 no 822 0.281984567264775 293 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1311 1190-0148 100 µM 0.576453086946541 0.243254843868545 no 823 0.28215448533296 332 1961333
SGTC_3233 9132340 49.47 µM 0.576278459411053 0.243311877631467 no 824 0.282213490088957 345 17682950
SGTC_956 1185-0240 191 µM 0.57315365568196 0.244333666522466 no 825 0.283270330164869 306 1416193
SGTC_683 panaxydol 45 µM 0.572752598398333 0.244464976697828 no 826 0.283406109100299 283 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2022 5136654 200 µM 0.572114312198979 0.244674036380807 no 827 0.283622266792131 332 1713771
SGTC_575 k072-0246 11.9 µM 0.571653924298093 0.24482488827132 no 828 0.283778227661036 307 6796779
SGTC_1803 st050068 52.4 µM 0.570688663573542 0.245141330537741 no 829 0.284105352334568 334 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1254 0550-0035 264 µM 0.56879969047152 0.245761230115981 no 830 0.284746042373197 313 15121435
SGTC_648 0375-0473 33.3 µM 0.56575045260591 0.24676366399518 no 831 0.285781716329101 322 1713139
SGTC_2278 7948257 134.34 µM 0.56497669293375 0.247018384502721 no 832 0.286044808594432 310 1247028
SGTC_196 k015-0023 18.111 µM 0.562968573921806 0.247680110005387 no 833 0.286728141757666 312 5211998
SGTC_2906 7926292 26.41 µM 0.561644940969838 0.248116797321725 no 834 0.287178977219633 334 2966319
SGTC_541 4513-1321 94 µM 0.561540454137286 0.248151286651015 no 835 0.287214580199792 320 747515
SGTC_871 0574-0004 149 µM 0.561216531144692 0.248258224379909 no 836 0.287324967420001 316 9551173
SGTC_2685 mycophenolic acid 18.85 µM 0.559466796564662 0.248836294424847 no 837 0.287921592778389 305 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.559240799605424 0.248911010580112 no 838 0.287998695969896 309 1241132 A phosphatase inhibitor.
SGTC_2623 humulene 100 µM 0.558767255626703 0.249067606203664 no 839 0.288160286169353 306 6187145 An anti-inflammatory.
SGTC_387 norethindrone acetate 66.7 µM 0.558615067076938 0.249117944357874 no 840 0.288212227445229 326 541197
SGTC_2755 lomerizine 42.69 µM 0.558102906049054 0.249287387389429 no 841 0.288387058160338 313 3949 A calcium channel blocker.
SGTC_2933 9026794 32.47 µM 0.557785680702177 0.249392368746231 no 842 0.288495370917465 336 17586027
SGTC_1491 4138-0063 26.5 µM 0.557344179752958 0.249538516503279 no 843 0.288646147974981 324 23883227
SGTC_2352 9027995 87.8 µM 0.557202589380317 0.249585396060917 no 844 0.288694510384193 314 2997347
SGTC_2288 7946289 167.31 µM 0.556979022130823 0.249659427100024 no 845 0.288770881048227 335 1246052
SGTC_1399 3562-5772 25 µM 0.556933271098806 0.249674578325515 no 846 0.288786510791848 316 23847490
SGTC_249 wiskostatin 11.211 µM 0.556864224516386 0.249697445189839 no 847 0.288810099656015 310 2775510 A n-wasp and actin depolymerizer.
SGTC_2123 5259487 200 µM 0.556494172776211 0.249820017969027 no 848 0.288936538460477 308 2173474
SGTC_2497 7-hydroxyflavone 100 µM 0.556276329765193 0.249892189362765 no 849 0.289010982959035 356 5281894
SGTC_1402 3909-7673 35.9 µM 0.556000422506397 0.249983613325238 no 850 0.289105282970224 307 5328014
SGTC_2341 7987486 176.74 µM 0.555903463107734 0.250015745771451 no 851 0.289138425339605 311 1258686
SGTC_1733 st037357 54.9 µM 0.555629119590229 0.250106675372115 no 852 0.289232210291352 318 1272339 YGL099W LSG1
SGTC_1215 3852-0577 11.2 µM 0.554525725301541 0.250472566238506 no 853 0.289609552459622 307 2884876
SGTC_2504 purpurogallin 52.29 µM 0.551512128909237 0.251473332904845 no 854 0.290641327250658 328 5281571 An antioxidant.
SGTC_190 3970-0790 3.722 µM 0.550196203476622 0.251910992348949 no 855 0.291092403642529 320 2832352
SGTC_2962 9082311 13.18 µM 0.549858512636654 0.252023368654065 no 856 0.291208210898008 336 16459453
SGTC_2162 5663267 200 µM 0.549486823736207 0.252147089360465 no 857 0.291335702265578 349 6456493
SGTC_1873 rapamycin 2 nM 0.546922664101192 0.253001469917535 no 858 0.292215932172127 323 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_105 0111-0055 734.78 µM 0.546425491628653 0.253167304417369 no 859 0.292386745648378 310 5179370
SGTC_3186 9110464 49.47 µM 0.544852893839219 0.253692228868499 no 860 0.292927348281184 332 17018021
SGTC_1871 st057448 67.3 µM 0.544385423063733 0.253848378162545 no 861 0.293088137334971 355 691747
SGTC_3044 9093193 49.47 µM 0.543246586248521 0.254228994956898 no 862 0.293480017537869 327 25236277
SGTC_2770 toltrazuril 17.5 µM 0.543006867290664 0.254309150829407 no 863 0.293562537099234 309 68591 Kills coccidiodes.
SGTC_2253 7938677 135.83 µM 0.542184857740178 0.254584110317799 no 864 0.293845582787007 309 2301972
SGTC_1690 st023502 41.2 µM 0.542117809157091 0.254606544715084 no 865 0.293868675449124 338 24207482
SGTC_933 2914-0560 114 µM 0.539569176541762 0.255460082133982 no 866 0.294747089176628 298 463887
SGTC_2870 9038528 12.99 µM 0.539102596183561 0.25561650171183 no 867 0.294908032153982 329 6463316
SGTC_2845 9003024 42.97 µM 0.535002151653689 0.256993311173356 no 868 0.296324184717232 302 2990173
SGTC_1548 st061468 90.8 µM 0.534512524597251 0.257157971080986 no 869 0.29649349325985 330 390799
SGTC_1611 st001856 99.4 µM 0.534348167960019 0.257213255952064 no 870 0.296550336212723 365 647478
SGTC_3064 1327-0027 10 µM 0.533485884863357 0.257503404533109 no 871 0.296848639700684 321 16000455 YPR107C YTH1
SGTC_58 0957-0393 9 µM 0.531252893166434 0.258255570619362 no 872 0.297621772064792 314 6997992
SGTC_359 0081-0058 15.9 µM 0.530940944330702 0.258360738768604 no 873 0.297729851739256 395 3494159
SGTC_2413 inermin 26.06 µM 0.530658315881909 0.258456041213902 no 874 0.297827788353305 365 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_379 3970-0972 5.9 µM 0.52979344365965 0.258747789618247 no 875 0.298127575729898 318 2898042 YBL034C STU1
SGTC_917 harmaline 728.087 nM 0.529115823732601 0.258976491009434 no 876 0.298362552556632 310 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2114 5491910 81.25 µM 0.529005314202929 0.259013798650183 no 877 0.298400881705824 361 2849228
SGTC_258 haloperidol 50.781 µM 0.528728149767314 0.259107380645652 no 878 0.298497023335638 335 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2027 5150920 200 µM 0.527114319451844 0.25965262247822 no 879 0.29905710168523 328 786715
SGTC_2212 7123476 200 µM 0.52589319894548 0.260065578320964 no 880 0.299481207285607 314 1085715
SGTC_1116 jasmonic acid 1.58368 µM 0.525305670060582 0.260264388132854 no 881 0.299685358197433 361 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1553 gossypol 38.6 µM 0.524324818740981 0.260596466004679 no 882 0.300026318755605 333 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_946 3434-1334 87.4 µM 0.524322526866298 0.2605972421991 no 883 0.300027115655613 320 4047976
SGTC_776 4476-4378 112 µM 0.524125864241231 0.260663850810762 no 884 0.300095500119286 349 2892008
SGTC_959 1222-0044 107 µM 0.523977245009133 0.260714193186678 no 885 0.300147183382285 346 6083612
SGTC_858 0438-0351 2.77 µM 0.523457353668851 0.260890337377045 no 886 0.300328010492492 306 2799119
SGTC_2377 9073351 62.6 µM 0.522874599839032 0.261087852717472 no 887 0.300530760754805 354 7337946 YHR072W ERG7
SGTC_3347 9188721 44.724 µM 0.520099183669329 0.262029590498783 no 888 0.301497223672206 362 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2097 5376186 200 µM 0.51949134112891 0.262236072220792 no 889 0.301709074792881 325 742755
SGTC_2918 7977171 22.06 µM 0.519126234084879 0.262360137707777 no 890 0.301836357574256 332 2236483
SGTC_742 0kpi-0133 140 µM 0.518598081936605 0.2625396600409 no 891 0.302020523457457 351 2728852
SGTC_3176 9106582 49.47 µM 0.518383732761459 0.262612536645191 no 892 0.302095281096362 309 17018027
SGTC_1928 4'-methoxychalcone 40.3 µM 0.517832829829649 0.262799885686369 no 893 0.302287455245616 363 641818
SGTC_206 4546-0025 72.014 µM 0.517195466569439 0.263016723096794 no 894 0.302509858182532 344 6620745 YIL048W NEO1
SGTC_3209 9113616 49.47 µM 0.514980600494699 0.263770953251246 no 895 0.303283288134005 356 16649353
SGTC_2914 7968218 45.32 µM 0.514944879785598 0.26378312628497 no 896 0.303295769025101 333 2977111
SGTC_2761 levamisole 97.89 µM 0.514688359238013 0.263870552709023 no 897 0.303385404588832 347 26879 An alkaline phosphatase inhibitor.
SGTC_1709 st033179 39.1045 µM 0.514519158240169 0.263928227277898 no 898 0.303444534700375 325 573381
SGTC_3321 9137793 26.8275 µM 0.514213282808677 0.264032505578139 no 899 0.303551441036946 326 4904192
SGTC_710 3448-4187 58 µM 0.513655663412862 0.264222661820164 no 900 0.303746377520324 325 3946412
SGTC_2948 9070189 9.45 µM 0.512514648552882 0.264611981567049 no 901 0.304145435457223 316 6473636 YDL196W YDL196W
SGTC_1899 st063254 59.6 µM 0.512181922012415 0.264725564387005 no 902 0.304261847039389 324 3093813
SGTC_2794 7785382 27.27 µM 0.511007700262847 0.265126606363418 no 903 0.304672832428941 364 2205081
SGTC_1383 3049-0032 20.7 µM 0.510226821048483 0.265393477438821 no 904 0.304946281922391 361 712864
SGTC_173 1273-0061 2.693 µM 0.507093411467355 0.266465711917756 no 905 0.306044638828452 339 2847414 YPL266W DIM1
SGTC_961 1252-1571 372 µM 0.505205275895687 0.267112877310422 no 906 0.306707332552257 361 6813498
SGTC_1137 ixabepilone 100 µM 0.504619072987913 0.267313961809323 no 907 0.306913205514995 321 154225 A novel microtubule stabilizer.
SGTC_2300 7976697 71.57 µM 0.504097675170231 0.2674928804501 no 908 0.307096370277546 319 2236109
SGTC_2060 5238662 140 µM 0.504062459346059 0.267504967003075 no 909 0.307108743178097 333 790130
SGTC_2331 7980721 200 µM 0.503555815394081 0.267678884618746 no 910 0.307286774255626 342 2981221
SGTC_1390 3413-2614 145 µM 0.503497429179432 0.267698930740352 no 911 0.307307293675496 357 3421432
SGTC_3076 9116187 49.47 µM 0.502696482340268 0.267974001419363 no 912 0.307588841619756 359 27241210
SGTC_2678 equilin 100 µM 0.501483164907133 0.268390964226735 no 913 0.308015561548199 312 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3128 9127691 49.47 µM 0.500907282359927 0.268588983358239 no 914 0.308218188549961 360 41316314
SGTC_3056 9094900 49.47 µM 0.50064927901828 0.268677722477627 no 915 0.308308987212747 326 25236784
SGTC_988 1497-1057 103 µM 0.500437333774986 0.268750631135397 no 916 0.308383585505349 363 3533044
SGTC_383 2324-0395 7.37 µM 0.500214618102216 0.268827255502689 no 917 0.30846198318825 337 3146421
SGTC_1942 st076330 65.2 µM 0.500090913518607 0.268869820270544 no 918 0.308505531955863 354 24208414
SGTC_1560 lithocholic acid 53.1 µM 0.499710746368094 0.269000650882123 no 919 0.308639382263477 334 9903 A bile acid which acts as a detergent.
SGTC_1005 4092-0690 4.4 µM 0.499599800061872 0.269038837934094 no 920 0.308678449341849 354 1529343
SGTC_2690 usnic acid 100 µM 0.497699660971057 0.269693276427679 no 921 0.309347873545301 357 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.49656370150933 0.270084899633366 no 922 0.309748377798276 333 6708514
SGTC_2111 5486399 200 µM 0.49505970519164 0.270603841246594 no 923 0.310278988085427 335 689674
SGTC_1424 4048-1941 275 µM 0.492040539260412 0.271647080823548 no 924 0.31134534269996 359 X1424
SGTC_331 k048-0133 24.5 µM 0.49162104275022 0.271792191509034 no 925 0.311493632416527 333 6813582
SGTC_840 0245-0196 390 µM 0.491577693747832 0.271807188834823 no 926 0.311508957795143 324 3827528
SGTC_1456 k015-0012 13 µM 0.490031105943636 0.272342526511019 no 927 0.312055943833611 358 2989616
SGTC_2159 5658611 73.75 µM 0.489903026849747 0.272386883429448 no 928 0.312101260532674 356 793844
SGTC_542 3381-0244 89.3 µM 0.488752996768963 0.272785327633317 no 929 0.312508289294788 358 1112843
SGTC_2676 harmalol 100 µM 0.488366580434856 0.27291927191326 no 930 0.312645104548473 331 5459187 A monoamine oxidase inhibitor
SGTC_2986 9022445 71.43 µM 0.488108160379527 0.273008866778152 no 931 0.312736615621546 374 6459286
SGTC_764 1951-2361 146 µM 0.487565601299223 0.273197020769012 no 932 0.312928782860586 341 5438930
SGTC_2046 4110841 106 µM 0.486092058380755 0.273708354495239 no 933 0.313450948665627 339 44119630 YMR134W ERG29
SGTC_2336 9001819 198.65 µM 0.485584669805637 0.273884532773591 no 934 0.313630833912637 363 2989602
SGTC_2229 7354935 190 µM 0.482221536979108 0.275053713858317 no 935 0.31482428946843 361 318112
SGTC_2434 5670830 169.91 µM 0.481162045581923 0.275422550825567 no 936 0.315200666806163 359 1549830
SGTC_2407 paclitaxel 400 µM 0.480710330129685 0.27557987887394 no 937 0.315361194119238 398 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3205 9113483 49.47 µM 0.480669615399566 0.275594061584775 no 938 0.315375664733467 393 17018033
SGTC_89 0302-0250 142.109 µM 0.479786606046676 0.275901740407789 no 939 0.315689568893143 350 4203518 YLR208W SEC13
SGTC_1447 4239-0816 81.9 µM 0.479232276282007 0.276094979159814 no 940 0.315886697542417 330 1341554
SGTC_1787 fluconazole 80 µM 0.479066531539389 0.276152770497486 no 941 0.315945649232721 322 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1607 st000305 50.6 µM 0.478607975053216 0.276312689412693 no 942 0.31610877188476 361 5457690
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.47849429712507 0.276352340957395 no 943 0.316149216160934 356 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2620 irigenin 100 µM 0.477366219902443 0.276745972285566 no 944 0.316550682081449 375 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1415 3966-0071 78.1 µM 0.477043167783895 0.276858748684002 no 945 0.316665691378781 348 2893185
SGTC_792 4534-1957 155 µM 0.476972815968558 0.276883311248134 no 946 0.316690739573105 341 1717904
SGTC_2265 7929201 200 µM 0.475673146253782 0.277337268521891 no 947 0.31715362754656 394 1265108
SGTC_1354 1498-1681 81 µM 0.475337906301715 0.277454422378158 no 948 0.317273072456532 341 5754243
SGTC_1672 st016598 6.51 µM 0.474955863477368 0.277587961577377 no 949 0.317409216284965 371 4665860 YNL267W PIK1
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.473956256134687 0.277937512703704 no 950 0.317765550715944 352 15053
SGTC_2768 sulfasalazine 50.2 µM 0.473424214577409 0.27812364904158 no 951 0.317955278786535 351 5384001 An antioxidant and salicylic acid derivative.
SGTC_3021 9087658 49.47 µM 0.47238313739883 0.278488048817344 no 952 0.318326669146671 354 25237042
SGTC_950 1165-0508 94.1 µM 0.470711729046135 0.279073564322313 no 953 0.318923303683822 352 6148369
SGTC_94 0334-0113 514.748 µM 0.469753401529028 0.279409548372646 no 954 0.319265605105796 344 6795178
SGTC_3230 9131665 49.47 µM 0.468148242646769 0.279972747508669 no 955 0.31983929096851 356 15943720
SGTC_2233 sulbentine 40.3845 µM 0.46675390972437 0.280462420821053 no 956 0.320337977416362 340 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1754 st042065 16.137 µM 0.466420387103456 0.280579611454208 no 957 0.320457310710767 344 1126236 YIL048W NEO1
SGTC_3096 9117468 49.47 µM 0.464628145130448 0.281209761213604 no 958 0.321098886650087 342 41316311
SGTC_292 k038-0015 474 µM 0.461144503770739 0.282436556201537 no 959 0.322347467154116 340 46368540
SGTC_1997 st073024 93.8 µM 0.460770137357882 0.282568545646263 no 960 0.32248176440963 348 686268
SGTC_1265 0819-1001 68.8 µM 0.460768709169719 0.282569049235821 no 961 0.322482276790963 388 3106768
SGTC_1028 k015-0029 4.8 µM 0.454407843761377 0.284816205885053 no 962 0.324767653922024 350 4588309
SGTC_1430 4049-0248 69.1 µM 0.451909556006218 0.28570112341278 no 963 0.325667069985841 371 22774488
SGTC_754 3474-0146 171 µM 0.450731317764381 0.286118920138135 no 964 0.326091603918763 328 24762078
SGTC_2476 5806916 10.51 µM 0.448777712657727 0.28681229655531 no 965 0.326796008933168 360 2870194
SGTC_745 0469-0705 296 µM 0.448548215611418 0.28689380223172 no 966 0.326878798528781 388 3486736
SGTC_2879 9041815 71.43 µM 0.447225566852585 0.287363753548552 no 967 0.32735610162709 345 4942971
SGTC_2679 rapamycin 1 nM 0.446843997978647 0.287499396723546 no 968 0.32749385057118 335 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1776 st049249 45.9 µM 0.446070669031421 0.287774398743961 no 969 0.327773099576454 343 1822314
SGTC_1763 st044482 94.5 µM 0.444838538607784 0.288212810822319 no 970 0.328218220736953 355 88505
SGTC_2385 9074692 200 µM 0.444822370381783 0.288218565834181 no 971 0.328224063316242 344 17046906
SGTC_778 3456-2434 196 µM 0.444363765597921 0.28838182684285 no 972 0.328389803062346 330 5539063
SGTC_1732 st034308 51.822 µM 0.444067789423804 0.288487216023268 no 973 0.328496786773815 329 830119
SGTC_2686 alizarin 95.37 µM 0.442477174919894 0.289053901849471 no 974 0.329071971836039 323 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_878 0828-0289 13.7 µM 0.440894946905382 0.289618118743295 no 975 0.329644526012951 358 745350 YLR208W SEC13
SGTC_2863 9028737 58.44 µM 0.43917074632104 0.290233550582475 no 976 0.330268910102132 383 6460917
SGTC_1469 k284-2957 126 µM 0.438419095445436 0.290502034577753 no 977 0.330541253268314 349 23884841
SGTC_1035 k081-0041 55.2 µM 0.437243112019388 0.290922319977267 no 978 0.330967523468263 388 731709
SGTC_2092 5303694 80.6725 µM 0.43510310966313 0.291687864850034 no 979 0.331743793182774 365 1963699
SGTC_3054 9094397 49.47 µM 0.435015535999885 0.291719212639527 no 980 0.331775575289956 377 2598354
SGTC_90 0870-0863 4.608 µM 0.434692903769562 0.291834715326798 no 981 0.33189267495799 387 1738164
SGTC_1689 st020265 53.493 µM 0.434066125160474 0.292059163622041 no 982 0.332120211774236 379 5758320 YPR016C TIF6
SGTC_1882 5615643 20 µM 0.433980130900456 0.292089964279764 no 983 0.332151434742265 344 2253075
SGTC_837 0091-0265 12.5 µM 0.432153507610317 0.292744564761592 no 984 0.332814923734773 372 759367
SGTC_2985 9022375 71.43 µM 0.431893785942518 0.292837695581825 no 985 0.332909305680122 350 4939335
SGTC_2851 9015922 71.43 µM 0.431884252926072 0.292841114186091 no 986 0.332912770146415 388 2996893
SGTC_56 0957-0365 83.25 µM 0.431762240000121 0.292884870483669 no 987 0.332957113054928 351 6752360
SGTC_1552 6-methylflavone 10.6 µM 0.430840239499169 0.293215616534461 no 988 0.333292269299617 378 689013
SGTC_457 grayanotoxin iii 135 µM 0.430205624366888 0.293443370388904 no 989 0.333523035523419 353 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1872 amphotericin b 148 nM 0.428594693639541 0.294021876996559 no 990 0.334109103927217 378 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_164 4100-3994 89.624 µM 0.427981265800863 0.294242305602682 no 991 0.334332379953504 401 4615967
SGTC_3095 9117207 49.47 µM 0.42758535851251 0.294384611091273 no 992 0.334476513783638 353 17015229
SGTC_1160 4092-0570 10.5 µM 0.427090745484241 0.294562440147376 no 993 0.334656616664666 351 4994975
SGTC_735 3076-0345 636 µM 0.424414160524854 0.295525615966983 no 994 0.335631897668787 352 2888990
SGTC_2034 5197015 53.07 µM 0.423959330462348 0.295689431558459 no 995 0.335797736782252 387 780676
SGTC_3265 9137266 49.47 µM 0.423497088284257 0.295855959507016 no 996 0.335966311252237 351 17224265
SGTC_1685 st024049 53.0905 µM 0.422516068229485 0.296209525668514 no 997 0.336324187429782 383 1941139
SGTC_2999 9069765 71.4286 µM 0.422350960912522 0.296269050495498 no 998 0.336384433183794 354 2097066
SGTC_2953 9074162 66.49 µM 0.422074420906669 0.296368761550099 no 999 0.336485348850317 387 16451992
SGTC_257 daunorubicin 18.5 µM 0.421092962430607 0.296722766702847 no 1000 0.336843600164651 386 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_43 0570-0105 72.5 µM 0.418303014025504 0.297730137293357 no 1001 0.337862793128087 364 1114046 YDL195W SEC31
SGTC_784 4579-0127 173 µM 0.415428645923362 0.298769618151224 no 1002 0.338914069987338 403 1948547
SGTC_1482 3346-2049 8.48 µM 0.41534370388897 0.29880036150048 no 1003 0.338945155991934 352 3826804
SGTC_968 1309-0633 340 µM 0.415211767228176 0.298848116619631 no 1004 0.338993442666434 379 3761976
SGTC_833 3852-0053 558 µM 0.414991665023297 0.298927791405709 no 1005 0.339074002384914 368 3123681
SGTC_1280 0880-0253 10.1 µM 0.414171123210656 0.299224904294542 no 1006 0.339374394132043 373 6836607
SGTC_674 0498-0004 451 µM 0.414058695886003 0.299265623937905 no 1007 0.33941556055293 359 4231473
SGTC_2054 5233173 129 µM 0.413879431609488 0.299330556213003 no 1008 0.339481203974749 335 6889
SGTC_3336 9143619 71.43 µM 0.413616298998061 0.299425878459713 no 1009 0.339577567325215 352 45595730
SGTC_1846 st056244 14.8 µM 0.413440848417263 0.299489444718975 no 1010 0.339641825949022 380 5393182
SGTC_1935 st074532 41.6 µM 0.4133590478115 0.299519083408782 no 1011 0.339671786943662 407 2829742
SGTC_3203 9113543 49.47 µM 0.411484088935896 0.300198798571508 no 1012 0.34035880293936 367 17018012
SGTC_630 4356-0227 183 µM 0.411424081411682 0.300220564174997 no 1013 0.340380799457896 389 779312
SGTC_1703 st026983 48.3 µM 0.408760255648144 0.301187490479023 no 1014 0.3413578047346 371 1104023
SGTC_3073 9114972 49.47 µM 0.408375845581105 0.301327140967151 no 1015 0.341498881954791 394 41905075
SGTC_102 gallobenzophenone 83.616 µM 0.407562344070217 0.301622770117004 no 1016 0.341797507322376 391 70837
SGTC_910 3454-3003 490 µM 0.407134776558424 0.301778201852594 no 1017 0.341954501266771 392 820824
SGTC_2628 lathosterol 100 µM 0.406994189884556 0.301829316571846 no 1018 0.34200612775682 360 6710616
SGTC_2998 9066762 71.4286 µM 0.405619224432583 0.302329433606621 no 1019 0.342511200626284 400 4945196
SGTC_1433 4060-0023 7.6 µM 0.405249667284118 0.302463916215422 no 1020 0.342646999960148 357 3840627
SGTC_1256 0570-0116 285 µM 0.403977011826437 0.30292724325124 no 1021 0.343114811883134 364 410638
SGTC_444 curcumin 90.4 µM 0.402399872554768 0.30350186199042 no 1022 0.34369488190141 369 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_991 3996-0057 64.7 µM 0.401495996914792 0.303831401530402 no 1023 0.344027492406716 344 715343
SGTC_2375 9072683 200 µM 0.400171020044695 0.304314756532032 no 1024 0.344515278968302 395 16798029
SGTC_2525 harmine 47.85 µM 0.400028210922435 0.304366874106058 no 1025 0.344567869207932 406 5280953 A monoamine oxidase inhibitor
SGTC_2711 st079103 59.1 µM 0.399636767813225 0.304509749952014 no 1026 0.344712035673328 401 54693780
SGTC_1054 3429-0080 167 µM 0.398512953894148 0.304920105203156 no 1027 0.345126055769695 389 1162877
SGTC_911 3456-4043 236 µM 0.397456708292788 0.305306012014323 no 1028 0.345515352353383 374 914281
SGTC_2740 felodipine 17.08 µM 0.397190608273421 0.305403267699091 no 1029 0.345613453658493 402 3333 L-type calcium channel blocker
SGTC_602 3130-1533 38.1 µM 0.396833930000402 0.305533649962389 no 1030 0.345744964102536 393 720941
SGTC_156 3474-0145 5.642 µM 0.393857197322031 0.30662274290733 no 1031 0.346843236481175 377 2265471
SGTC_2474 5321570 43.32 µM 0.393458589406372 0.306768711028422 no 1032 0.346990401783254 415 2841384
SGTC_2902 5787006 60.46 µM 0.393265093653878 0.306839579205507 no 1033 0.347061848378972 363 591003
SGTC_3091 9116372 49.47 µM 0.393230674675666 0.306852185976314 no 1034 0.347074557851985 354 17169793
SGTC_900 1112-0045 141 µM 0.392736547179933 0.307033197117878 no 1035 0.347257037193855 367 56211 YIL048W NEO1
SGTC_806 3966-4455 5.86 µM 0.392242057468355 0.307214388043635 no 1036 0.347439685755283 371 714982
SGTC_1376 2910-0861 41.3 µM 0.391060521941703 0.30764751686696 no 1037 0.347876250292733 374 1112859
SGTC_2730 imipramine 71.33 µM 0.390402384303691 0.307888894185213 no 1038 0.348119512524129 340 3696 A tricyclic antidepressant.
SGTC_2307 7538926 6.34 µM 0.387661979539751 0.308894852888736 no 1039 0.349133097792056 361 96582
SGTC_1188 1403-0014 4.57 µM 0.387544218938823 0.308938113133735 no 1040 0.349176677740347 365 9614867
SGTC_1026 k007-1105 30.6 µM 0.387219563748617 0.309057391391014 no 1041 0.349296833964509 359 7066794
SGTC_40 0327-0103 19.753 µM 0.386552591825332 0.309302499913154 no 1042 0.349543730405988 374 409036
SGTC_3197 9113331 49.47 µM 0.38603066484668 0.309494364424098 no 1043 0.349736979217324 348 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2965 9082772 38.63 µM 0.38529553255507 0.309764692994089 no 1044 0.350009235518505 333 16459634
SGTC_2493 resveratrol 26.09 µM 0.383234007952669 0.31052332148894 no 1045 0.350773132313788 353 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1153 4055-0057 267 µM 0.382918418430146 0.310639527779357 no 1046 0.35089012719231 375 882706
SGTC_366 0181-0206 4.31 µM 0.380708737212671 0.311453704828332 no 1047 0.351709692451154 378 274874
SGTC_464 bw-b 70c 158 µM 0.380375870629722 0.311576432617906 no 1048 0.351833211699157 407 5353454
SGTC_1931 st074438 57.1 µM 0.379642899844904 0.311846752476804 no 1049 0.352105255673961 412 2787313
SGTC_426 0988-0037 14.6 µM 0.379311688466652 0.311968936607425 no 1050 0.352228210464478 416 5383008
SGTC_2841 9004761 38.96 µM 0.378606948310277 0.312228984634643 no 1051 0.352489880820623 345 2991039
SGTC_681 1642-0006 26.6 µM 0.378446402033092 0.3122882390538 no 1052 0.352549501499585 421 4446530
SGTC_1835 st008666 49.2 µM 0.378208543724883 0.312376036721935 no 1053 0.35263783953607 367 690455
SGTC_1981 st071826 47 µM 0.378023807541503 0.312444233433516 no 1054 0.352706454065803 364 11838600
SGTC_1103 duloxetine 36.1 µM 0.376782780635249 0.312902534024211 no 1055 0.353167519168969 382 60835 A selective serotonin reuptake inhibitor.
SGTC_2646 retinol 96.75 µM 0.376074978694706 0.313164048813322 no 1056 0.353430577660239 394 445354 A vitamin A analog and teratogen.
SGTC_712 r015-0009 80.6 µM 0.375262772983918 0.313464253958886 no 1057 0.353732524669978 390 6813872 YLR060W FRS1
SGTC_887 0885-0007 9.62 µM 0.372937254932343 0.314324488402416 no 1058 0.354597571785151 405 5719458
SGTC_2909 7941780 10.49 µM 0.371403034470128 0.314892566223268 no 1059 0.355168682885816 376 1243215
SGTC_3133 9127736 49.47 µM 0.371215150904162 0.314962164263791 no 1060 0.355238644637302 389 27243420
SGTC_627 1391-0720 175 µM 0.370524805451926 0.315217946559792 no 1061 0.355495748800494 429 997839
SGTC_314 1671-0008 2.74 µM 0.370482725627419 0.315233540568319 no 1062 0.355511422644631 389 3913060
SGTC_879 0831-1030 162 µM 0.370096530470835 0.315376672758354 no 1063 0.355655283577045 367 1549252
SGTC_1397 3532-0190 20.1 µM 0.36914963492946 0.31572772974234 no 1064 0.356008097082875 353 5322280
SGTC_512 prima-1 270 µM 0.368691347963588 0.31589769718618 no 1065 0.356178899228875 370 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_396 dithiazanine 1.25 µM 0.368579972749854 0.315939009414571 no 1066 0.356220412789925 364 10578 An antihelmenthic.
SGTC_2350 9023895 38.85 µM 0.367494328665195 0.316341825980203 no 1067 0.356625160715947 389 2997209
SGTC_3093 9117344 49.47 µM 0.365958883739176 0.316911908473342 no 1068 0.357197878259524 367 24824913
SGTC_1724 st037281 8.293 µM 0.365250574187887 0.317175037487158 no 1069 0.35746218471794 366 574124 YDL195W SEC31
SGTC_1955 wogonin 32.4 µM 0.364746364503578 0.317362402042565 no 1070 0.357650372769689 348 5281703 A flavanone.
SGTC_1980 st071811 45.7 µM 0.363850076147278 0.317695578758559 no 1071 0.357984983222747 400 4974850
SGTC_1291 0993-0025 5.79 µM 0.362698801657476 0.318123757981066 no 1072 0.358414947495915 396 4353356
SGTC_487 nimodipine 119 µM 0.361813250105035 0.318453275681159 no 1073 0.358745794947648 413 4497 L-type voltage-gated calcium channels inhibitor
SGTC_590 k048-0076 22.4 µM 0.360659208201881 0.318882915433495 no 1074 0.359177111106992 398 6832814
SGTC_2103 5378138 10 µM 0.360206188467936 0.319051637323427 no 1075 0.359346473588954 391 244142
SGTC_1096 rimcazole 32.2 µM 0.3592790478694 0.319397056837151 no 1076 0.359693173391962 403 18528119 A dopamine reuptake inhibitor.
SGTC_2150 5556613 200 µM 0.358989853915348 0.319504832282949 no 1077 0.35980133973669 394 743190
SGTC_1151 3909-8316 15.3 µM 0.358228033938776 0.319788816749104 no 1078 0.360086334707818 397 800431
SGTC_2490 carminic acid 95.39 µM 0.357863546085781 0.31992472466833 no 1079 0.360222716233479 387 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_39 0986-0283 58.349 µM 0.357485820445756 0.320065594117041 no 1080 0.360364069753137 366 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_57 miconazole 162.5 nM 0.356802592740899 0.320320463765195 no 1081 0.360619797566789 404 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_298 1391-0729 10 µM 0.356012002433666 0.320615489515299 no 1082 0.360915788331622 392 3237558
SGTC_3125 9127534 49.47 µM 0.354755085473832 0.32108476840123 no 1083 0.361386539581141 383 1639235
SGTC_3075 9116269 49.47 µM 0.354501718188878 0.321179399526011 no 1084 0.361481458303183 390 17015205 YNL244C SUI1
SGTC_751 0833-0568 350 µM 0.354436751695837 0.321203665982949 no 1085 0.361505798006362 407 6954252
SGTC_322 k048-0136 19.3 µM 0.353821222025366 0.321433618129152 no 1086 0.361736434057823 385 6823282
SGTC_1002 4049-0206 172 µM 0.351696992316012 0.322227722048178 no 1087 0.362532758213946 385 4662749
SGTC_3183 9108214 49.47 µM 0.351455399844889 0.322318088416575 no 1088 0.362623363346019 396 4974831
SGTC_2362 9071156 126 µM 0.350692440623476 0.322603538151704 no 1089 0.362909548668474 378 653133
SGTC_1243 0416-0003 5.65 µM 0.350467898988666 0.322687566959642 no 1090 0.362993788627627 396 2141977
SGTC_1409 3909-8004 61.9 µM 0.349978500695676 0.322870742786903 no 1091 0.363177416261146 379 2119279
SGTC_2715 st079500 56.4 µM 0.349731432069196 0.322963233896856 no 1092 0.363270131083325 399 28246688
SGTC_2941 9056145 11.23 µM 0.349455208484236 0.323066652243542 no 1093 0.363373796062718 426 2119517
SGTC_496 calpeptin 138 µM 0.349213377341143 0.323157205261337 no 1094 0.363464561990214 376 73364 A calpain inhibitor.
SGTC_3142 9086498 49.47 µM 0.347284735510024 0.323879754688836 no 1095 0.364188708655104 414 25236367
SGTC_1919 st067113 52.3 µM 0.343274453930001 0.325384296923197 no 1096 0.365695998653894 395 1268243
SGTC_1795 st049545 62.3 µM 0.342278751080979 0.325758298631755 no 1097 0.366070562547728 376 5291882
SGTC_3317 9138495 8.753 µM 0.34020008612749 0.326539643080001 no 1098 0.366852926664507 390 17020139
SGTC_2854 9024559 71.43 µM 0.339236709599797 0.326902022896275 no 1099 0.367215708434009 387 3163529
SGTC_2889 9059656 51.95 µM 0.338257664096733 0.327270464014483 no 1100 0.367584512207602 383 3949838
SGTC_2939 9044578 71.43 µM 0.338002539760717 0.327366501820269 no 1101 0.367680636926168 406 2653634
SGTC_507 nimesulide 162 µM 0.336855326009152 0.327798494719662 no 1102 0.368112981862195 415 4495 A COX2 inhibitor.
SGTC_407 eburnamonine 100 µM 0.336441963547266 0.327954206332591 no 1103 0.368268804768315 378 3195
SGTC_1737 st035557 69.7 µM 0.336407030744596 0.327967366719141 no 1104 0.368281974182556 387 5716916
SGTC_3168 9103419 49.47 µM 0.336298877483055 0.328008113121711 no 1105 0.368322748162072 424 16649256
SGTC_430 0958-0115 16.4 µM 0.336183728695009 0.328051497316984 no 1106 0.368366161098044 392 6833180
SGTC_1131 3454-3128 32.3 µM 0.336093246827139 0.32808558947312 no 1107 0.368400275389495 360 710982
SGTC_1450 4112-4260 37.6 µM 0.33553519142364 0.328295887690779 no 1108 0.3686107014021 421 1633175
SGTC_1283 0922-0125 16.4 µM 0.335360947545269 0.328361561099489 no 1109 0.368676411635951 398 3360884
SGTC_301 4119-0100 24.5 µM 0.334854877729328 0.328552331468187 no 1110 0.368867280656535 420 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_753 1322-0200 289 µM 0.334000430975943 0.328874529009556 no 1111 0.369189616727272 384 5403907
SGTC_2890 9046729 58.44 µM 0.333976507705704 0.328883551905358 no 1112 0.369198642994914 390 903329
SGTC_1590 st077108 57.8 µM 0.333324320270799 0.329129569189084 no 1113 0.369444741565504 392 5489485
SGTC_1634 st006576 41 µM 0.332992008727486 0.329254951784713 no 1114 0.369570157688667 435 3915356
SGTC_2143 5623677 140.463 µM 0.332621338037935 0.329394830112782 no 1115 0.369710067129199 396 5375313
SGTC_2839 9003951 25.97 µM 0.331844391078351 0.329688100549068 no 1116 0.370003381271071 420 2990634
SGTC_2109 5483026 200 µM 0.331790705097454 0.329708369009539 no 1117 0.37002365167582 425 759335
SGTC_3107 9121808 49.47 µM 0.331660748864387 0.329757434405872 no 1118 0.370072721202893 361 662681
SGTC_3255 9139072 49.47 µM 0.331433604708622 0.329843200452281 no 1119 0.37015849251244 380 17646060
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.331185584893316 0.32993685903588 no 1120 0.370252153999806 416 368090
SGTC_1646 st011709 75.6 µM 0.331185289855856 0.329936970455871 no 1121 0.370252265421483 392 5757843
SGTC_2739 tacrine 100.86 µM 0.330946594278394 0.330027118050708 no 1122 0.370342413004739 407 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1974 st069448 26.9 µM 0.330688651180892 0.330124545907518 no 1123 0.370439837758413 394 6323587 YNR016C ACC1
SGTC_3330 9141424 71.43 µM 0.330424336097433 0.330224392482762 no 1124 0.370539677823437 380 27261020
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.329141559729691 0.330709140414501 no 1125 0.371024346276173 373 16623 A steroid.
SGTC_3342 9147791 14.508 µM 0.327855475185926 0.33119542366158 no 1126 0.37151047011878 408 1838168
SGTC_2309 7664088 163.95 µM 0.325802509364798 0.331972263453878 no 1127 0.372286890019855 427 704922
SGTC_3294 9122953 26.2835 µM 0.325560801369843 0.332063773093349 no 1128 0.372378336836046 418 16459826
SGTC_2431 5490079 200 µM 0.325159306754634 0.332215799417096 no 1129 0.372530252572244 407 5722345
SGTC_3177 9107506 49.47 µM 0.324773802173676 0.332361797087455 no 1130 0.372676136735813 425 8897194
SGTC_2139 5578692 56.4705 µM 0.32428447881908 0.332547149473887 no 1131 0.372861334713797 404 650991 YMR113W FOL3
SGTC_350 k064-0020 19.8 µM 0.32400516577567 0.332652969732127 no 1132 0.372967061650679 389 2790705
SGTC_2799 7812892 81.82 µM 0.322907488443994 0.333068963772091 no 1133 0.373382652455456 407 20205235
SGTC_1226 3909-7979 35.4 µM 0.32217302518145 0.333347422959555 no 1134 0.373660809347794 404 6615510
SGTC_762 1165-0429 115 µM 0.320138752589267 0.334119161863234 no 1135 0.374431574977469 428 5967793
SGTC_1009 4106-0057 9.87 µM 0.320100638577591 0.334133627826198 no 1136 0.374446020797941 430 2928005
SGTC_607 4491-0986 66.8 µM 0.320082398332183 0.334140550897942 no 1137 0.374452934205258 387 698981 YDR232W HEM1
SGTC_2048 5246248 200 µM 0.319780446249247 0.334255164787004 no 1138 0.374567385773063 399 677046
SGTC_922 1866-0035 480 µM 0.319775653643464 0.334256984071749 no 1139 0.374569202445933 415 3156169
SGTC_2295 7971645 200 µM 0.318843564033979 0.334610881509303 no 1140 0.374922570824703 422 2978226 YKL099C UTP11
SGTC_2777 climbazole 1.536 µM 0.318675928446535 0.334674545290558 no 1141 0.3749861350031 419 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2016 5121758 140 µM 0.317365039863032 0.335172551601504 no 1142 0.375483315624061 423 2795203
SGTC_187 1488-2104 32.728 µM 0.316960952371697 0.335326122847425 no 1143 0.375636615610106 413 2852859
SGTC_2595 hexamethylquercetagetin 100 µM 0.315837832790294 0.335753102805317 no 1144 0.376062800201114 434 386331
SGTC_2401 5128683 200 µM 0.315736573561644 0.335791609282175 no 1145 0.376101231974007 412 708373
SGTC_27 0485-0001 32.618 µM 0.315734272562086 0.335792484317627 no 1146 0.376102105306141 420 2054479
SGTC_564 3555-0129 330 µM 0.315429249133017 0.335908488009949 no 1147 0.376217880940281 418 563260
SGTC_2142 5622915 118.518 µM 0.310658981533788 0.337724700150867 no 1148 0.378029941640882 395 5322196
SGTC_2021 4019055 173 µM 0.310301344227977 0.337861018570609 no 1149 0.378165904514016 403 44827708 YER133W GLC7
SGTC_684 1140-0066 328 µM 0.308934617348641 0.338382161296546 no 1150 0.378685631564327 395 6813534
SGTC_1505 k297-0037 20.6 µM 0.306948543760851 0.339140017219233 no 1151 0.379441269398974 383 4089396
SGTC_1900 st060200 72.8 µM 0.305883365178211 0.339546741946029 no 1152 0.379846725984066 399 688945
SGTC_264 promethazine 12.5 mM 0.305368684366844 0.339743333204583 no 1153 0.380042684845791 438 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_440 fluspirilene 35.1 µM 0.304992284992896 0.339887133077016 no 1154 0.380186014125966 411 3396 An atypical antipsychotic.
SGTC_1604 st002052 72.4 µM 0.304242108021837 0.340173800677686 no 1155 0.380471723399422 376 6254834 YHR062C RPP1
SGTC_844 0330-0132 15.3 µM 0.303828779174035 0.340331786888556 no 1156 0.380629169975722 441 2828079
SGTC_3116 9124943 49.47 µM 0.303353583139174 0.34051345515857 no 1157 0.380810207636367 368 41905195 YPL160W CDC60
SGTC_1804 st050076 49.1 µM 0.302595276396512 0.340803433784832 no 1158 0.381099157349499 407 3895976
SGTC_1186 1319-0216 26 µM 0.301862538153708 0.341083724339848 no 1159 0.381378427284885 401 4565136
SGTC_2524 avocatin b 10.57 µM 0.300364494987749 0.341657035871668 no 1160 0.381949571467207 431 6710748
SGTC_1191 1487-1166 10.6 µM 0.299759189178665 0.341888794357705 no 1161 0.382180423440821 432 3955771
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.2996712682911 0.341922462320358 no 1162 0.382213958259497 447 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2726 cimetidine 79.27 µM 0.298966010047078 0.342192575672992 no 1163 0.382482990079712 437 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2260 7964312 200 µM 0.298638812769536 0.34231791940817 no 1164 0.382607823886431 397 231951
SGTC_643 k048-0106 28.4 µM 0.29724283798175 0.342852888726095 no 1165 0.383140559490094 430 6763920
SGTC_418 lividomycin a 100 µM 0.297172960471059 0.342879675672574 no 1166 0.383167232149833 401 72394 An antibiotic.
SGTC_1688 st021091 57.6 µM 0.296520999877454 0.343129637240574 no 1167 0.383416116045851 428 3656366
SGTC_3099 9120367 49.47 µM 0.295418908985401 0.34355233475922 no 1168 0.383836945131593 448 24824940
SGTC_734 2023-0417 80 µM 0.295279326436637 0.343605884424167 no 1169 0.38389025396722 433 3935732
SGTC_3194 9111903 49.47 µM 0.295038735322055 0.343698192538545 no 1170 0.383982144766753 431 17087251
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.294961803600519 0.343727711065705 no 1171 0.384011529262575 432 551469
SGTC_2226 7298446 200 µM 0.294635469933496 0.343852935144927 no 1172 0.38413618161986 433 3283010
SGTC_2602 kawain 100 µM 0.294617431705576 0.343859857457279 no 1173 0.384143072179959 418 5369129
SGTC_1976 st070609 63.5 µM 0.293868854612032 0.344147175959681 no 1174 0.384429059114903 444 682556
SGTC_920 mycophenolic acid 780.421 nM 0.292627342817273 0.344623890756276 no 1175 0.384903505818098 398 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1269 0831-0796 3.05 µM 0.29249495357545 0.344674740059456 no 1176 0.384954108867458 430 927758
SGTC_3117 9124945 49.47 µM 0.290639787342717 0.345387584560221 no 1177 0.385663413538908 393 17592065
SGTC_302 1094-0063 18.9 µM 0.288642537402628 0.34615563792312 no 1178 0.386427470082545 413 5440289
SGTC_501 nsc-95397 161 µM 0.28802273071061 0.346394116865131 no 1179 0.386664669506962 430 262093
SGTC_2367 9070478 135.38 µM 0.286824744228176 0.346855230800048 no 1180 0.387123257736799 417 572802
SGTC_179 1273-0063 6.77 µM 0.286790873389029 0.346868271240391 no 1181 0.387136225759685 434 3108139
SGTC_2115 tiliquinol 12.7705 µM 0.285312611725992 0.347437585806944 no 1182 0.38770232574093 434 71208 A bioactive hydroxyquinoline.
SGTC_2680 butyl paraben 22.24 µM 0.284499013699044 0.347751069217976 no 1183 0.388013994888292 430 7184 An antifungal and steroid mimetic.
SGTC_2275 7947463 200 µM 0.284298754240276 0.347828246170509 no 1184 0.388090720373332 421 1225414
SGTC_410 α-linolenic acid 100 µM 0.284181891746004 0.347873286113725 no 1185 0.388135495965204 442 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1889 st059080 5.18 µM 0.281587516014591 0.348873735576976 no 1186 0.389129906895189 403 176925 Isolated from Daphnopsis sellowiana.
SGTC_986 1493-0483 84 µM 0.280887280796722 0.349143942491252 no 1187 0.389398428268915 437 40079
SGTC_21 0849-0113 22.993 µM 0.280022022611513 0.349477934155441 no 1188 0.389730304457904 410 1560156
SGTC_2606 farnesol 9.78 µM 0.279368737664108 0.349730180904783 no 1189 0.389980930034399 428 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2102 5377816 72.7585 µM 0.278480701806871 0.350073176189246 no 1190 0.390321688549243 438 1379702
SGTC_2506 ethyl hematommate 54.16 µM 0.27812999094158 0.35020866859516 no 1191 0.390456287102346 413 3940691 An allergen.
SGTC_2343 7990716 14.84 µM 0.275395221794378 0.351265862593255 no 1192 0.391506307336218 417 6456862
SGTC_1495 4469-0029 237 µM 0.273497149200166 0.352000288185441 no 1193 0.392235541723912 418 793680
SGTC_95 0471-0001 561.058 µM 0.273126760228786 0.352143668148729 no 1194 0.392377888401918 375 4015405
SGTC_1446 4239-0190 62 µM 0.272603767008679 0.35234615799581 no 1195 0.392578907964724 433 1340085
SGTC_1037 k284-1091 78.7 µM 0.271978395755213 0.35258834099782 no 1196 0.392819315540203 434 3334711
SGTC_3270 9137563 49.47 µM 0.269909423867085 0.353390002236529 no 1197 0.393614968484285 452 17015724
SGTC_52 0329-0193 875 nM 0.269509971461271 0.35354485249479 no 1198 0.393768634946501 443 3739292
SGTC_979 1426-2828 121 µM 0.265187597262539 0.355221993792916 no 1199 0.395432474460879 428 747872
SGTC_2298 7976326 193.81 µM 0.265043740620782 0.355277860634984 no 1200 0.395487883102491 422 2235818
SGTC_1493 4348-0038 111 µM 0.26474018025184 0.355395758753137 no 1201 0.395604811070574 449 800424
SGTC_1708 st033234 31.827 µM 0.264091128763984 0.355647886658431 no 1202 0.395854849763851 400 674664
SGTC_14 0354-0009 295 µM 0.26352252654858 0.355868815481585 no 1203 0.396073931641077 466 1713507
SGTC_288 1315-0019 35.1 µM 0.263293708410866 0.355957735803884 no 1204 0.396162104313292 432 6811474
SGTC_2486 5283202 22.39 µM 0.2628432065235 0.356132826872981 no 1205 0.396335716017204 413 1377751
SGTC_1508 1080-0625 72.9 µM 0.262511099900307 0.356261922130366 no 1206 0.396463714433436 424 767111
SGTC_2200 6600604 21.907 µM 0.261793236094019 0.356541023771128 no 1207 0.396740427036477 450 2904777
SGTC_2536 dehydroabietamide 32.04 µM 0.261637488589804 0.356601587724131 no 1208 0.396800469385701 416 3983547
SGTC_2213 7173844 200 µM 0.261450675495903 0.356674236607494 no 1209 0.396872491083446 421 892728
SGTC_2473 5854593 8.94 µM 0.260581299015276 0.357012392787686 no 1210 0.397207706389633 423 2872951
SGTC_1368 1852-0141 284 µM 0.259920071819401 0.357269661630816 no 1211 0.397462714088508 418 2838987
SGTC_2519 cryptotanshinone 88.04 µM 0.258885662978849 0.357672257312222 no 1212 0.397861730231771 409 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2983 9022671 12.99 µM 0.258799195020135 0.357705918136352 no 1213 0.397895089501639 452 6405161
SGTC_2644 guaiazulene 100 µM 0.257484988504973 0.358217657318932 no 1214 0.39840220109358 441 3515 A coloring agent.
SGTC_2625 euphol 100 µM 0.257306545198106 0.35828716106711 no 1215 0.398471070091376 464 6708538 A triterpene alcohol.
SGTC_2945 9067681 61.76 µM 0.257284843278994 0.35829561429467 no 1216 0.398479446017258 461 16456930
SGTC_1746 st038117 42 µM 0.256919682902749 0.358437860227889 no 1217 0.398620387856667 450 2898218
SGTC_3061 glucosamine 200 µM 0.256148138817778 0.358738474968457 no 1218 0.398918226070351 460 91431 and experimental redox chemotherapeutic
SGTC_2586 curcumin 80 µM 0.256067313947375 0.358769971623271 no 1219 0.398949430204879 407 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2884 9058502 51.95 µM 0.255260908802119 0.359084272315461 no 1220 0.399260795140402 415 6471554
SGTC_2533 agelasine 13.65 µM 0.255210702944428 0.35910384347235 no 1221 0.399280182485047 452 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_525 k781-2675 26.7 µM 0.254267641080098 0.359471534804009 no 1222 0.399644398556163 425 3651118 YDL195W SEC31
SGTC_3180 9109287 49.47 µM 0.252453574231748 0.360179188869524 no 1223 0.400345247250453 421 18891271
SGTC_3351 9150312 21.596 µM 0.252173718082356 0.360288401424368 no 1224 0.400453395838272 451 4904905
SGTC_1629 st005085 44.9 µM 0.251902817426432 0.360394129999986 no 1225 0.400558090904109 458 24207091
SGTC_547 1120-0019 610 nM 0.250979796987777 0.360754451532405 no 1226 0.400914864518059 432 3676939
SGTC_1183 1254-0324 198 µM 0.250912639587425 0.360780672744614 no 1227 0.400940825989921 414 5799357
SGTC_2232 chlorophetanol 41.5365 µM 0.25024476806752 0.361041474853441 no 1228 0.40119903320597 437 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_328 k915-0120 63.5 µM 0.249975638074188 0.361146587694579 no 1229 0.401303094325737 423 6624543
SGTC_2819 7996655 46.38 µM 0.249676102226043 0.361263588336942 no 1230 0.401418920327974 461 6456960
SGTC_473 2-arachidonoylglycerol 10 µM 0.248839832499472 0.361590309375432 no 1231 0.401742339061676 443 5282280 An endocannabinoid.
SGTC_2624 nerol 100 µM 0.247414587210866 0.362147368949212 no 1232 0.402293693045344 431 637566 A natural product oil.
SGTC_3343 9148379 18.9835 µM 0.246592826428075 0.362468688408739 no 1233 0.402611678410114 442 1955036
SGTC_73 0327-0325 16.231 µM 0.245647649453296 0.362838385069726 no 1234 0.402977500100855 426 53298
SGTC_716 1683-5115 658 µM 0.24302107582814 0.363866413975697 no 1235 0.403994535321936 455 723597
SGTC_832 4083-0019 164 µM 0.242807560755188 0.363950025996675 no 1236 0.404077239093924 414 1990758
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.24272090141741 0.363983963446203 no 1237 0.404110807287712 453 688798
SGTC_2911 7942208 15.64 µM 0.242639807447269 0.364015722357894 no 1238 0.404142220330962 419 1243384
SGTC_1220 1838-0075 193 µM 0.240907315674005 0.364694442628868 no 1239 0.404813476008593 439 5529645
SGTC_711 k292-0785 179 µM 0.239061269236262 0.365418115969003 no 1240 0.405529036881836 455 4146315
SGTC_2921 7974240 10.71 µM 0.237855222792787 0.365891160368339 no 1241 0.405996692950148 435 2979074 YDR527W RBA50
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.237657742714089 0.365968636907639 no 1242 0.406073280544088 458 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1267 0828-0272 9.49 µM 0.237556978750273 0.366008171321387 no 1243 0.406112360653519 440 745334
SGTC_725 1497-0963 19 µM 0.234611792218741 0.367164332583863 no 1244 0.407255028061084 456 3549977
SGTC_382 3229-0966 23.2 µM 0.231639483172148 0.368332363504343 no 1245 0.40840901914837 453 5722370
SGTC_2563 tomatine 8.54 µM 0.229984659205863 0.368983189674913 no 1246 0.409051845205553 469 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1971 st069429 63.5 µM 0.229778096229233 0.369064455306655 no 1247 0.409132103015595 460 1246522 YGL099W LSG1
SGTC_2873 9040596 71.43 µM 0.228024482653085 0.369754594208418 no 1248 0.409813603719369 462 6463863
SGTC_1091 telmisartan 47.6 µM 0.226922420723675 0.370188528306655 no 1249 0.410242033785555 442 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1540 guanosine 70.6 µM 0.226082678176929 0.37051928579336 no 1250 0.410568558319896 460 6802 Guanosine is a purine nucleoside
SGTC_998 3996-0085 177 µM 0.225958878714665 0.370568055983328 no 1251 0.410616701610587 436 715391
SGTC_2502 avocadyne acetate 18.59 µM 0.224817343930762 0.371017855929918 no 1252 0.411060686466035 401 3952079
SGTC_1874 staurosporine 7.6 µM 0.224664324325852 0.371078163790339 no 1253 0.411120210091148 469 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_654 1124-0271 80.9 µM 0.224333929439376 0.371208389331762 no 1254 0.41124873851771 448 5403748
SGTC_2237 6667747 47.222 µM 0.223536140038704 0.371522899754825 no 1255 0.411559129471883 467 729940 YDL015C TSC13
SGTC_695 3505-6186 243 µM 0.221916584681298 0.372161636475313 no 1256 0.412189409850936 436 1819379
SGTC_3018 9082602 49.47 µM 0.221872695427856 0.372178950870901 no 1257 0.412206493338285 442 17332089
SGTC_2245 6637752 200 µM 0.221168407044437 0.372456829327947 no 1258 0.412480653831797 443 681890
SGTC_1539 benzyladenosine 56 µM 0.220446065868166 0.372741899538061 no 1259 0.412761886154482 409 92208 A nucleotide analog.
SGTC_36 0335-0881 14.2 µM 0.219926649842895 0.372946928922052 no 1260 0.412964140409108 437 23828853
SGTC_2184 6075246 200 µM 0.21987129856628 0.372968779886184 no 1261 0.412985694883224 463 2267320
SGTC_1113 artemisinin 1.17947 µM 0.219155497662297 0.373251392633573 no 1262 0.413264460248056 451 2240 An anti-malaria and mitochondrial poison.
SGTC_1956 st077085 54 µM 0.217369885779326 0.373956685479137 no 1263 0.413960048898425 469 24208685
SGTC_2592 piperlongumine 83.33 µM 0.216294867564964 0.374381507079622 no 1264 0.41437895473675 436 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2346 9031566 143.75 µM 0.215591590381521 0.374659508056645 no 1265 0.414653055779817 451 4771086
SGTC_158 k038-0087 26.446 µM 0.21538607435236 0.374740759538652 no 1266 0.41473316314329 432 X158
SGTC_317 4495-0002 170 µM 0.215306695865844 0.374772143590269 no 1267 0.414764104751267 438 15991618
SGTC_1077 5-fluorocytosine 377 nM 0.215197538848691 0.3748153026013 no 1268 0.414806654846762 465 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_466 geldanamycin 89.2 µM 0.215101086448166 0.37485343970653 no 1269 0.414844253434176 447 5288382 HSP90 inhibitor.
SGTC_3354 9151612 71.43 µM 0.214746030483337 0.37499383873672 no 1270 0.414982666274841 456 27261949
SGTC_2570 licareol 100 µM 0.213636233403539 0.375432790193178 no 1271 0.4154153707389 443 443158
SGTC_2321 7390090 138.78 µM 0.211365764340751 0.376331317426689 no 1272 0.416300934667167 445 649046
SGTC_2725 haloperidol 53.21 µM 0.211120737793743 0.376428325683786 no 1273 0.416396529251447 468 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1926 methyl fluorone black 53.6 µM 0.210137116250559 0.376817828977139 no 1274 0.416780328785028 443 72721 Reacts with homocysteine.
SGTC_2238 6671620 73.2395 µM 0.208066681433766 0.377638107747494 no 1275 0.417588451089967 400 729941
SGTC_2788 5282734 71.43 µM 0.20581994237473 0.378528860579767 no 1276 0.418465781467893 448 743706
SGTC_1364 1653-0028 37.6 µM 0.203561072920714 0.379425073787913 no 1277 0.419348257727065 478 5718652
SGTC_2827 7993847 71.43 µM 0.202945650674281 0.379669356978497 no 1278 0.419588756286321 466 2985692
SGTC_645 0845-0943 5.41 µM 0.202623478207568 0.379797257961295 no 1279 0.419714668844827 444 1885106
SGTC_2977 9011197 71.43 µM 0.202179826751333 0.379973407063657 no 1280 0.419888071693083 499 2704722
SGTC_3213 9129884 49.47 µM 0.201060265409163 0.380418032701449 no 1281 0.420325725553093 420 17190742
SGTC_1140 3229-1848 2.98 µM 0.200460354588442 0.380656347984379 no 1282 0.420560280555777 464 2849525
SGTC_3257 9139206 32.98 µM 0.199948167534468 0.380859850743744 no 1283 0.420760559372903 462 4910041
SGTC_3114 9122766 49.47 µM 0.198538899195266 0.381419952853747 no 1284 0.421311726640952 425 17176985
SGTC_1161 k007-0610 110 µM 0.19760512320815 0.381791211358468 no 1285 0.421677013053598 460 5843850
SGTC_1117 retinoic acid 1.10837 µM 0.197528372756013 0.381821731289631 no 1286 0.421707040277515 463 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3297 9117502 71.43 µM 0.196930977900136 0.382059311337309 no 1287 0.42194077574031 437 7453720
SGTC_122 0236-0016 402.397 µM 0.196786103766018 0.382116933533432 no 1288 0.421997463037393 454 6808838
SGTC_603 3794-0023 45.9 µM 0.195675058507489 0.382558927063822 no 1289 0.422432253718497 449 3802260
SGTC_2760 etidronate 98.04 µM 0.194819383656483 0.382899434054942 no 1290 0.422767173537128 457 3305 A chelator and antioxidant.
SGTC_1330 1469-0054 61.8 µM 0.194771981585502 0.382918299869252 no 1291 0.42278572882311 479 7102664
SGTC_904 1141-0088 396 µM 0.190708817845666 0.384536448940505 no 1292 0.424376864924168 462 1378119
SGTC_2467 5474540 200 µM 0.190349775607871 0.384679534240548 no 1293 0.424517525649957 444 5413519
SGTC_2455 5377712 9.75 µM 0.18835467400241 0.3854749066355 no 1294 0.425299314297596 425 2243908
SGTC_720 r052-1644 49.9 µM 0.187522402489045 0.385806844797897 no 1295 0.425625530290743 461 1422863 YOR257W CDC31
SGTC_476 mead acid 10 µM 0.185187230162409 0.386738636692138 no 1296 0.42654109235781 458 5312531 An omega 9 fatty acid.
SGTC_1494 4358-1428 177 µM 0.18499663339146 0.386814718457546 no 1297 0.426615838081561 470 1564571
SGTC_119 0121-0043 24.815 µM 0.184420513683064 0.387044718381888 no 1298 0.426841789110809 465 1092378
SGTC_200 k038-0079 37.545 µM 0.18440928631475 0.387049200993729 no 1299 0.426846192662581 457 3436683
SGTC_2925 9010536 32.5 µM 0.183689344788308 0.387336674530942 no 1300 0.427128584151306 445 2994177
SGTC_123 0083-0120 66.675 µM 0.18342108967631 0.387443804937169 no 1301 0.427233814699812 471 16001701
SGTC_1751 st044839 27.194 µM 0.181580453841909 0.388179112346601 no 1302 0.427955994701452 461 5291326
SGTC_2629 bisabolol 100 µM 0.181422626748783 0.388242180693285 no 1303 0.428017929992529 487 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_417 st075190 100 µM 0.178232992381179 0.389517401008634 no 1304 0.429270000175724 477 222757
SGTC_3283 9109332 35.8195 µM 0.177156417752743 0.389948086484789 no 1305 0.429692763859354 474 17027281
SGTC_672 1441-0018 53.7 µM 0.176995534174516 0.390012459848374 no 1306 0.42975594870586 443 251141
SGTC_3319 9138450 16.7555 µM 0.173927832546813 0.391240495780123 no 1307 0.430961089391062 480 2029690
SGTC_3166 9102297 49.47 µM 0.173488199736615 0.391416574978163 no 1308 0.431133851244732 454 25237072
SGTC_548 1436-0017 110 µM 0.17338693741713 0.391457135132755 no 1309 0.431173646016609 474 9677137
SGTC_1623 st003709 20.3 µM 0.173316468995296 0.391485361630232 no 1310 0.431201339600346 474 16192618
SGTC_1112 tnp00069 1.16933 µM 0.172403434095497 0.391851134179346 no 1311 0.431560186292867 484 145826
SGTC_303 1348-1668 34.2 µM 0.172381397667266 0.391859963415324 no 1312 0.431568847887184 454 5380509
SGTC_1471 k673-0312 37 µM 0.172338778891904 0.391877039445195 no 1313 0.431585599630964 462 24099884
SGTC_2418 pentamidine 31.67 µM 0.170372838213994 0.392664957179318 no 1314 0.432358465899298 474 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3273 9137859 49.47 µM 0.16972590764686 0.392924333050642 no 1315 0.432612849159674 494 2377234
SGTC_3 0833-0587 95.581 µM 0.169451036194596 0.393034552511636 no 1316 0.432720941393644 447 5382644
SGTC_1339 1486-1321 22.7 µM 0.168792607719445 0.393298607628611 no 1317 0.432979886540575 454 3469382
SGTC_906 1165-0455 526 µM 0.168466440631731 0.393429431353139 no 1318 0.433108171404855 476 3252859
SGTC_406 estrone 100 µM 0.166250050919028 0.39431873037376 no 1319 0.433980086256695 476 5870 A steroid.
SGTC_3202 9113761 49.47 µM 0.165340155162563 0.394683974664972 no 1320 0.434338127242295 486 4798415
SGTC_613 3914-0030 117 µM 0.161257601137446 0.396323901699341 no 1321 0.435945257770393 483 1145395
SGTC_2234 tolnaftate 200 µM 0.160003156792413 0.396828171383965 no 1322 0.436439293748226 481 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1813 st051246 8.6015 µM 0.158528064312259 0.397421359367304 no 1323 0.437020354070455 479 5291959
SGTC_1312 1218-2183 165 µM 0.158220955629183 0.397544888757486 no 1324 0.437141345767252 484 6744073
SGTC_2089 5281248 129.67 µM 0.157275415078887 0.397925281278943 no 1325 0.437513897519483 446 2737878
SGTC_2010 4012422 159 µM 0.15638675984404 0.398282877225463 no 1326 0.437864086442071 460 952393
SGTC_1792 st045773 43.6 µM 0.155340181650315 0.398704131110759 no 1327 0.438276569845099 473 2919270
SGTC_2249 haloperidol 116.36 µM 0.155324445858822 0.398710465761419 no 1328 0.438282772238399 493 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3016 9080866 49.47 µM 0.154414469722291 0.399076834008769 no 1329 0.438641472650789 497 17066299
SGTC_2804 7954240 19.48 µM 0.154274820683825 0.399133066409269 no 1330 0.438696524901011 466 828705
SGTC_2825 7998094 58.44 µM 0.154009758558272 0.399239804583776 no 1331 0.438801020585707 488 2987815
SGTC_208 k072-0098 12.366 µM 0.151842615820348 0.400112775708154 no 1332 0.439655534626999 478 5948901
SGTC_1550 gossypolone 36.6 µM 0.149311332580488 0.401133062399554 no 1333 0.440653986703149 470 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_574 1315-0397 40 µM 0.145862776993074 0.40252415932553 no 1334 0.442014858451394 486 6794277
SGTC_589 1227-0070 34.1 µM 0.145236008181153 0.402777121866703 no 1335 0.442262268453878 479 2841384
SGTC_2195 6536160 144.242 µM 0.14461203462338 0.403028996683507 no 1336 0.442508597433247 456 3834386
SGTC_378 3970-0959 8.33 µM 0.143829009681953 0.403345131528481 no 1337 0.442817747314356 490 6615653
SGTC_2896 9052656 71.43 µM 0.143799787311958 0.403356930856207 no 1338 0.442829285415337 487 6469436
SGTC_2640 pentamidine 10.38 µM 0.143034591050345 0.403665930969785 no 1339 0.443131431175316 481 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_246 cycloheximide 667 µM 0.142602933497982 0.403840268653578 no 1340 0.443301890283079 478 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.142549979139992 0.403861657155302 no 1341 0.443322802380516 462 115019
SGTC_2692 st077426 47.7 µM 0.142336110710399 0.403948042493565 no 1342 0.443407262331179 510 25238571
SGTC_2630 antimycin a 100 µM 0.14078177379031 0.404576007865692 no 1343 0.444021171029204 466 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2216 7189485 200 µM 0.140020132685703 0.404883807231021 no 1344 0.444322041752768 484 731273
SGTC_435 c-PAF 6.7 µM 0.139495151325935 0.405096000396667 no 1345 0.444529443581474 497 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_346 4513-0042 7.16 µM 0.139339191477996 0.405159043468677 no 1346 0.444591060807891 452 2827372
SGTC_2157 5649910 96.377 µM 0.138522903319207 0.405489048724152 no 1347 0.444913584936232 480 2858091
SGTC_2179 6298986 200 µM 0.137572963336444 0.405873170712862 no 1348 0.445288962223857 494 738374
SGTC_715 0868-0130 184 µM 0.135509038444474 0.406708060572023 no 1349 0.446104709263561 465 2876258
SGTC_2438 5259590 200 µM 0.13539388615501 0.406754654000989 no 1350 0.446150228882817 494 1201127
SGTC_1279 0874-0590 65.2 µM 0.133373721551312 0.407572276077573 no 1351 0.446948913439769 468 3523074
SGTC_61 0978-8327 98.565 µM 0.13333738233126 0.407586987363995 no 1352 0.446963282355094 469 6150059 YHR072W ERG7
SGTC_82 0054-0107 293.755 µM 0.13273118904545 0.407832413130305 no 1353 0.447202987901439 497 3104697
SGTC_175 3793-3120 23.7 µM 0.131915735466264 0.408162617873 no 1354 0.447525471148424 502 5322297
SGTC_1016 4226-1401 38 µM 0.131517509265697 0.408323896854727 no 1355 0.447682968243316 508 2901613
SGTC_1377 2944-0135 198 µM 0.130920304791986 0.408565789824083 no 1356 0.44791917601547 461 1894137
SGTC_994 3910-0338 138 µM 0.129031177749206 0.409331194843138 no 1357 0.448666489378986 490 3479481
SGTC_2005 4024620 188 µM 0.128953500639747 0.409362674180941 no 1358 0.448697221320908 511 236743
SGTC_3345 9148410 3.559 µM 0.127854680373042 0.409808043361252 no 1359 0.449131988214448 502 4903596
SGTC_1719 st032227 49.2 µM 0.125432376539043 0.410790251635852 no 1360 0.450090628871135 493 3125804
SGTC_1772 st048439 82.2 µM 0.123563913326764 0.411548268439848 no 1361 0.450830283226623 504 2927068 YDL195W SEC31
SGTC_2608 thymoquinone 42.66 µM 0.123124916158756 0.411726413210461 no 1362 0.451004090576047 499 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3078 9116413 49.47 µM 0.122546978514834 0.411960967679178 no 1363 0.451232921429283 496 17177322
SGTC_2876 9059903 25.97 µM 0.122527156146283 0.411969013093617 no 1364 0.451240770262023 495 6916095
SGTC_2310 7668677 200 µM 0.121437360727454 0.412411391240851 no 1365 0.45167231312949 500 2197143
SGTC_3224 9130643 49.47 µM 0.120238946874731 0.412897989091513 no 1366 0.452146933208419 465 17644395
SGTC_1826 st055655 41.6 µM 0.120099196212024 0.412954741467642 no 1367 0.452202284556655 505 676168
SGTC_1089 terbinafine 2.25 µM 0.119944903179289 0.413017401575015 no 1368 0.452263396811963 477 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_29 0299-0004 12.984 µM 0.119333744226822 0.413265621745056 no 1369 0.452505475237045 512 16871 A napthoquinone isolated from Swertia calycina.
SGTC_32 0928-0142 34.1 µM 0.118181851326749 0.413733553389872 no 1370 0.452961784858386 498 2244242
SGTC_1073 triclabendazole 3.09 µM 0.116178873151595 0.414547511466754 no 1371 0.453755390069844 466 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3028 9087778 49.47 µM 0.116016878982606 0.414613357761846 no 1372 0.453819582317347 505 17217395
SGTC_2327 6189656 200 µM 0.114213107385265 0.41534670434569 no 1373 0.454534430855707 503 5349088
SGTC_2110 5483698 200 µM 0.113881542749995 0.415481538392051 no 1374 0.454665848560271 489 2848765 YHR062C RPP1
SGTC_64 000l-0018 272.079 µM 0.113754536196351 0.415533189503592 no 1375 0.454716189712667 498 6811119
SGTC_835 0312-0010 67.2 µM 0.112302067061319 0.41612398421121 no 1376 0.455291951447598 506 1626196
SGTC_1292 0kpi-0043 232 µM 0.112253183282265 0.416143871090485 no 1377 0.455311330718002 500 3333905
SGTC_623 k072-0108 16.9 µM 0.111863196539603 0.41630253302442 no 1378 0.455465939151785 497 5382803
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.111748959939979 0.416349011546768 no 1379 0.455511228999705 509 756377
SGTC_1973 st070275 50.2 µM 0.111494944396951 0.416452364989791 no 1380 0.455611937196261 506 17118334
SGTC_2963 9082507 9 µM 0.109062376267116 0.41744241600241 no 1381 0.456576508110114 487 16459611
SGTC_2950 9072895 21.46 µM 0.10752393047883 0.418068831475888 no 1382 0.45718667079809 479 17332245
SGTC_3062 9077494 49.47 µM 0.107496171606815 0.418080136087316 no 1383 0.457197681170365 467 16459633
SGTC_560 2332-1943 155 µM 0.105618439108846 0.41884498651279 no 1384 0.45794254714447 514 21177716
SGTC_3017 9080681 49.47 µM 0.105486594146585 0.418898702038065 no 1385 0.457994853480062 498 16451914
SGTC_1848 st056003 16.4 µM 0.103236756571197 0.419815550309951 no 1386 0.458887534112462 505 146492
SGTC_3324 9138759 60.749 µM 0.102658329741388 0.420051339946816 no 1387 0.459117073447819 488 45595710
SGTC_1916 st067606 49.2 µM 0.101993756443512 0.420322281712753 no 1388 0.459380815438281 490 19590279
SGTC_2000 st075254 36.4 µM 0.0998543980234979 0.421194738591264 no 1389 0.460229960219027 472 17234175
SGTC_601 0986-0029 62.9 µM 0.0997891912415677 0.421221336825856 no 1390 0.460255844678083 505 24747981
SGTC_2033 5192550 145 µM 0.0991585395299771 0.421478601949837 no 1391 0.460506196614348 504 182073
SGTC_813 k007-0158 173 µM 0.098628985298701 0.421694651735443 no 1392 0.460716427639686 526 6523916
SGTC_3308 9128332 17.569 µM 0.0979506694584521 0.421971428342404 no 1393 0.460985732493446 504 17332805 YDL196W YDL196W
SGTC_1297 1068-0111 14.1 µM 0.0970744200313251 0.422329025819078 no 1394 0.461333647380172 510 767057
SGTC_1504 k297-0033 30 µM 0.0968320628087595 0.42242794314224 no 1395 0.461429880565779 471 4388117
SGTC_2835 9006588 71.43 µM 0.0953060765165459 0.423050881691674 no 1396 0.46203585813238 448 2345538
SGTC_3162 9099653 49.47 µM 0.0925800855373441 0.42416416445069 no 1397 0.463118582614051 518 25237511
SGTC_2414 st077232 92.9 µM 0.0902773725937506 0.425105054406163 no 1398 0.464033400385866 508 729801
SGTC_834 0312-0008 75.7 µM 0.0899948408912015 0.425220526538612 no 1399 0.464145657283134 508 6385573 YIL048W NEO1
SGTC_1260 0700-1617 7.75 µM 0.089218889887125 0.425537694605545 no 1400 0.464453976642197 515 2853078
SGTC_1892 st058411 7.36 µM 0.0888990221300933 0.425668453804177 no 1401 0.464581080351874 516 3934738
SGTC_372 0155-0182 15.9 µM 0.0870620122202948 0.426419565577191 no 1402 0.465311110273135 500 771486
SGTC_1624 st003710 6.25 µM 0.0867529009204024 0.426545980504708 no 1403 0.465433963014777 516 24207033
SGTC_2255 7941087 197.44 µM 0.0866463272267147 0.426589566898129 no 1404 0.465476320271608 505 935561
SGTC_624 k048-0052 28 µM 0.0865838753512537 0.426615108814923 no 1405 0.465501141683074 484 6835531
SGTC_1115 galangin 695.678 nM 0.0863840680486194 0.426696829188275 no 1406 0.465580555720129 523 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_446 go6976 132 µM 0.085561020666908 0.427033485356918 no 1407 0.465907692892579 510 3501 A protein kinase C inhibitor.
SGTC_596 1155-0152 116 µM 0.0853439927256814 0.427122266505786 no 1408 0.465993958975404 515 280313
SGTC_1526 st051518 75 µM 0.0847913230054921 0.427348367661087 no 1409 0.466213645968153 475 673993
SGTC_540 1187-0821 17.3 µM 0.0846414602923516 0.427409681690533 no 1410 0.466273218384956 525 847520
SGTC_1184 1269-1718 139 µM 0.0802298106966435 0.429215419819801 no 1411 0.468027240534456 504 5403821
SGTC_1237 0330-0133 46.1 µM 0.079563963862311 0.429488088139062 no 1412 0.468292028495251 499 X1237 YHR072W ERG7
SGTC_334 1502-1024 68.5 µM 0.0787628982588127 0.429816173939005 no 1413 0.468610607616182 512 3296216
SGTC_3084 9116877 49.47 µM 0.0779474258387777 0.430150210007185 no 1414 0.468934936889477 517 27241325
SGTC_765 1319-0117 244 µM 0.0777336369978104 0.430237791065275 no 1415 0.469019968297481 480 3487746 YGL099W LSG1
SGTC_663 1486-0733 13.9 µM 0.0774924607324054 0.430336595816566 no 1416 0.469115894352034 502 722445 YPR165W RHO1
SGTC_3019 9081971 49.47 µM 0.0769487069155688 0.430559376105119 no 1417 0.469332174932228 501 16451803
SGTC_867 0518-0118 155 µM 0.0754803579372894 0.431161080662271 no 1418 0.469916262522282 517 6848158
SGTC_107 0358-0022 2.6945 µM 0.0749393568478339 0.431382814110989 no 1419 0.470131481171823 526 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2011 4012611 177 µM 0.07471103533788 0.431476399927409 no 1420 0.470222313642357 508 2049887
SGTC_2968 9090663 33.37 µM 0.0746458282571576 0.431503128110704 no 1421 0.470248255066936 515 25236811
SGTC_2565 isoliquiritigenin 100 µM 0.0742683940315875 0.431657843405074 no 1422 0.470398412732645 514 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1766 st045414 44.774 µM 0.0729299080830896 0.432206590902495 no 1423 0.470930947049333 513 253960
SGTC_1760 st045453 10.4495 µM 0.0723775872320884 0.432433067539889 no 1424 0.471150710402472 531 3323419 YIL048W NEO1
SGTC_174 3553-0389 74.3 µM 0.0723530123341322 0.43244314488077 no 1425 0.471160488731488 502 738071
SGTC_229 benomyl 22.8748 µM 0.0718708033726741 0.43264089147545 no 1426 0.471352362738592 485 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1972 st070201 17.4 µM 0.0707118419906385 0.433116232904508 no 1427 0.471813547943112 509 2829099
SGTC_233 rapamycin 362 pM 0.069053661591744 0.433796494309772 no 1428 0.472473452813061 519 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1134 3477-0009 42.5 µM 0.0684257232634895 0.434054154629869 no 1429 0.472723372805404 520 3973534
SGTC_1141 3253-0389 52.6 µM 0.0683137410518717 0.434100106950153 no 1430 0.47276794295262 518 5402031
SGTC_1802 st050112 57.9 µM 0.0680074226686665 0.434225810394867 no 1431 0.472889862765782 518 4662563
SGTC_2940 9060638 45.86 µM 0.0666336414659725 0.434789648682108 no 1432 0.473436681617378 498 4027022
SGTC_2125 5246583 200 µM 0.0661911363389001 0.434971293481049 no 1433 0.473612826738473 516 835267
SGTC_2061 5245884 80.95 µM 0.0661262043228969 0.434997948707534 no 1434 0.473638674236204 515 573863
SGTC_2443 5493264 126.67 µM 0.0652407706521525 0.435361457303644 no 1435 0.473991149985102 514 5340055
SGTC_1060 3448-7350 82 µM 0.0648116686239531 0.435537641809231 no 1436 0.47416197538355 511 570178
SGTC_2147 5545932 89.7195 µM 0.0646434559669787 0.435606711542747 no 1437 0.474228942093615 515 797404
SGTC_3033 9090887 49.47 µM 0.064521766910071 0.435656679463622 no 1438 0.474277387866458 499 19325384
SGTC_529 4076-0302 30.3 µM 0.064130799974553 0.435817225127187 no 1439 0.474433038741324 488 5816522
SGTC_2167 5876490 200 µM 0.0633978580545946 0.436118227005967 no 1440 0.474724846423428 524 686534
SGTC_2946 9065502 71.43 µM 0.0617490906738284 0.436795471681555 no 1441 0.47538132291205 509 16489101
SGTC_1322 1348-1070 12 µM 0.0614426311441786 0.436921372917556 no 1442 0.47550335086539 517 6758089
SGTC_183 3914-0051 30.55 µM 0.0612005324631882 0.437020837625887 no 1443 0.475599752842601 516 1596232
SGTC_3232 9132874 49.47 µM 0.0597900924189296 0.437600386937355 no 1444 0.476161408282498 526 3784940
SGTC_528 3492-0019 172 µM 0.0595892005661639 0.437682944250561 no 1445 0.476241409892179 535 2869262
SGTC_2231 micatex 6.853 µM 0.0587302584591605 0.438035960510416 no 1446 0.476583479081061 510 20737 An antifungal of unknown mechanism.
SGTC_2025 5147754 141 µM 0.0582316295647103 0.438240914435511 no 1447 0.476782063355548 523 315777 YLR208W SEC13
SGTC_1907 st060210 83.7 µM 0.0576769213752677 0.438468938376531 no 1448 0.47700298858051 518 688793
SGTC_3263 9137018 49.47 µM 0.0573516596390098 0.438602653250661 no 1449 0.477132534798889 526 43844957
SGTC_2508 celastrol 40.54 µM 0.0573387349288871 0.438607966734904 no 1450 0.477137682541154 522 122724 Celastrol is a natural product and antioxidant.
SGTC_1833 st055984 71 µM 0.0556020258641394 0.43932204635097 no 1451 0.4778294252987 511 676288
SGTC_3159 9100096 49.47 µM 0.0550596230798902 0.439545105732574 no 1452 0.478045481718061 514 25236875
SGTC_2674 ligustilide 100 µM 0.0532402881777352 0.440293434358984 no 1453 0.478770227896856 523 5319022 A signalling regulator.
SGTC_2534 helenine 20.12 µM 0.0528148876750396 0.440468440914308 no 1454 0.478939699703619 526 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3108 9121785 49.47 µM 0.0515473621104704 0.440989960179609 no 1455 0.479444681241363 526 17140271
SGTC_1273 0849-0096 14.1 µM 0.0512616545049358 0.441107527811134 no 1456 0.479558511591267 521 5286025
SGTC_2655 perillic acid 100 µM 0.0510744455407684 0.441184566428384 no 1457 0.479633099456465 530 5702197 An apoptosis inducer.
SGTC_177 1327-0068 8.361 µM 0.0503062558260214 0.441500708501664 no 1458 0.479939169327774 516 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1520 flindersine 88 µM 0.0494089536671998 0.441870032909474 no 1459 0.48029669644197 518 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_497 capsazepine 133 µM 0.0483564019488772 0.442303321534111 no 1460 0.480716102417238 530 2733484 A calcium channel blocker.
SGTC_1052 3253-3998 198 µM 0.047671504152079 0.442585300533707 no 1461 0.480989022332873 516 5450317
SGTC_3282 9108498 15.4605 µM 0.0474199136047389 0.442688890090591 no 1462 0.481089279055331 519 16459645
SGTC_3248 9135562 49.47 µM 0.0461717892134138 0.443202848962308 no 1463 0.4815866637164 507 17650701
SGTC_1165 k072-0275 30.3 µM 0.0461521972446809 0.443210917404813 no 1464 0.481594471457777 527 6153523 YGL055W OLE1
SGTC_1288 0973-0013 65.5 µM 0.0457489591405053 0.443376985749906 no 1465 0.48175517044154 531 4315430
SGTC_2171 5739187 198.077 µM 0.0455405675476234 0.443462813004863 no 1466 0.481838220098921 530 2262761
SGTC_1936 st074407 74.3 µM 0.0447389173512661 0.443793001859054 no 1467 0.482157706589678 531 809813
SGTC_1094 duloxetine 25.4 µM 0.0443092888399043 0.443969976097441 no 1468 0.48232893376226 520 60834 A selective serotonin reuptake inhibitor.
SGTC_1346 1488-2224 62.4 µM 0.0441128886066583 0.444050881764855 no 1469 0.482407209581907 525 3722427
SGTC_2281 7943571 200 µM 0.0432158843940814 0.444420425810094 no 1470 0.482764721501234 531 1244024
SGTC_2551 apiole 73.87 µM 0.0430345501676876 0.444495137008371 no 1471 0.482836996152037 522 10659 A possible DNA adduct former.
SGTC_1765 st044815 90.4 µM 0.0414322379786225 0.445155388264328 no 1472 0.483475656332167 537 645695
SGTC_1145 3546-0597 10.2 µM 0.040940796072526 0.445357923159022 no 1473 0.483671547066835 522 875334
SGTC_1961 st076550 68.7 µM 0.0394912571316751 0.445955395501661 no 1474 0.484249361939588 525 1579337
SGTC_2446 5162541 200 µM 0.0389264829066258 0.446188217982761 no 1475 0.484474501130089 531 1549321
SGTC_2916 7875993 68.79 µM 0.038504420811119 0.446362220945259 no 1476 0.484642753400926 532 1299250
SGTC_2272 7805186 180 µM 0.0378954990085724 0.446613278495386 no 1477 0.484885500872007 538 2956062 YPR165W RHO1
SGTC_2484 5809818 12.04 µM 0.0374829284719294 0.446783392879412 no 1478 0.485049975843619 535 2870548
SGTC_3173 9105693 49.47 µM 0.037021147093483 0.446973809884728 no 1479 0.485234072177264 525 17096658
SGTC_886 0866-0150 153 µM 0.0364563624317448 0.447206717233428 no 1480 0.485459236647569 531 271463
SGTC_1086 cerivastatin 2.18 µM 0.0361187388282212 0.447345956022425 no 1481 0.485593840325915 529 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1118 chelidonine 707.474 nM 0.0357426462592003 0.447501067373738 no 1482 0.48574378273199 537 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2688 kanamycin b 96.69 µM 0.0353012601942008 0.447683117873206 no 1483 0.485919759234459 531 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2664 lyso-paf C-16 73.48 µM 0.0349817566111282 0.447814904596105 no 1484 0.486047144042276 520 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2581 avocatin a 64 µM 0.0341028315058339 0.448177467482178 no 1485 0.486397575292396 531 6710728 A skin care supplement.
SGTC_1271 0832-2808 169 µM 0.032222444983609 0.448953285369236 no 1486 0.487147328481339 531 3663794
SGTC_2923 7992654 58.14 µM 0.0315684491788806 0.449223159653493 no 1487 0.487408102375475 536 2985126
SGTC_913 3487-1245 167 µM 0.0314966858827438 0.449252774530117 no 1488 0.487436717558863 535 4016153
SGTC_3089 9117425 49.47 µM 0.0308011075982265 0.449539836520447 no 1489 0.487714078552379 535 9401657
SGTC_1970 st070122 35.8 µM 0.0304219234985843 0.449696335203892 no 1490 0.487865280261372 541 102928
SGTC_1472 k841-0093 193 µM 0.0300229662310029 0.449861003210786 no 1491 0.488024368510537 526 X1472
SGTC_2888 9058547 12.99 µM 0.0287462118539768 0.450388036329517 no 1492 0.488533499925403 531 16476514
SGTC_1917 st066507 28.5 µM 0.0285541635676795 0.450467319787601 no 1493 0.488610084668465 530 3156428
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.0280142069607563 0.450690241116187 no 1494 0.488825410039081 534 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_351 caspofungin 25 nM 0.0276709552362445 0.45083196083738 no 1495 0.488962294596762 536 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1866 st057638 64 µM 0.0265604338811266 0.451290509114852 no 1496 0.489405165653043 535 688802
SGTC_3272 9137413 49.47 µM 0.0265200761385636 0.45130717456371 no 1497 0.489421260393446 518 17614870
SGTC_348 k064-0012 10.7 µM 0.0265068934292146 0.451312618290367 no 1498 0.489426517685404 529 5066323
SGTC_3145 9085516 49.47 µM 0.0262977223500225 0.451398995551139 no 1499 0.489509935792887 538 25236195
SGTC_694 1315-0438 43.2 µM 0.0255693404425449 0.451699799013911 no 1500 0.489800420426777 537 6793154
SGTC_1029 k015-0030 64.7 µM 0.0243859851703441 0.452188554119426 no 1501 0.490272363608287 540 2208316
SGTC_1407 3909-7909 12.3 µM 0.023389948267298 0.452599998285832 no 1502 0.490669611467408 542 4411780
SGTC_1263 0774-1208 64.8 µM 0.0225784766779757 0.452935239630291 no 1503 0.490993256286989 543 906585
SGTC_902 1120-0002 2.07 µM 0.0216372646109979 0.453324122360473 no 1504 0.491368653811006 541 3280475
SGTC_2131 toluylene red 5.2905 µM 0.0207155919868194 0.453704975317959 no 1505 0.491736265541122 533 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3134 9127454 49.47 µM 0.0206739580235923 0.453722180284684 no 1506 0.491752871533017 537 24262820
SGTC_772 k072-0172 35.3 µM 0.0190564266260133 0.45439068162208 no 1507 0.492398045813278 539 5861980
SGTC_1242 0402-0103 60.1 µM 0.0188239664046477 0.454486764590088 no 1508 0.492490767391337 532 432868
SGTC_207 4185-0010 4.486 µM 0.0173706093231915 0.45508754198184 no 1509 0.493070477989827 536 3761753
SGTC_2539 epi(13)torulosol 80 µM 0.0172579457766917 0.455134118266485 no 1510 0.493115417505378 537 6708597
SGTC_1374 2889-5571 141 µM 0.0170386828344316 0.455224765620214 no 1511 0.493202877902944 537 2853281
SGTC_453 enantio-paf c16 10 µM 0.0148515459718898 0.456129095274994 no 1512 0.494075308183271 540 13871343 A lipid and platelet activating factor
SGTC_1944 st076371 56.9 µM 0.0137518603769577 0.456583875577745 no 1513 0.494513974375734 545 24208455
SGTC_1478 0453-0656 35.7 µM 0.0123687861141096 0.457155933314479 no 1514 0.495065694076163 541 5258496
SGTC_2614 arthonioic acid 13.39 µM 0.0123248843174835 0.457174093136118 no 1515 0.495083207024096 541 6710684
SGTC_2808 7946468 45.46 µM 0.0119788863722434 0.457317217079087 no 1516 0.495221230041506 541 2970879
SGTC_533 1222-0222 6.71 µM 0.0110273748995451 0.457710843496142 no 1517 0.49560080307017 536 3982874
SGTC_336 4111-0029 111 µM 0.0104653255625227 0.457943374622782 no 1518 0.495825015364584 541 3131175
SGTC_534 k292-0788 63.4 µM 0.0100410122146998 0.458118931138117 no 1519 0.495994283000326 542 4146317
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.00872145523417777 0.458664940159582 no 1520 0.4965206868688 545 91467 include heat shock
SGTC_1244 0416-0015 52.5 µM 0.00832865684480662 0.458827488201807 no 1521 0.496677385058738 544 96201
SGTC_3287 9117173 37.0625 µM 0.00818393692521127 0.458887378014208 no 1522 0.496735117985673 545 2789709
SGTC_1314 1222-0010 41.1 µM 0.00500125885143405 0.460204707307419 no 1523 0.498004794706477 543 3526027
SGTC_2657 nystatin 74.44 µM 0.00468831163826634 0.460334261839275 no 1524 0.498129641115631 544 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1887 st057648 70.8 µM 0.00366267684750067 0.460758885685258 no 1525 0.498538806613119 547 688672
SGTC_861 0443-0273 110 µM 0.00160908501384407 0.461609228832561 no 1526 0.499358068232227 542 6149169
SGTC_2148 5546263 113.568 µM 0.00156956116987628 0.461625596442971 no 1527 0.499373835944755 546 792097
SGTC_3245 9134821 49.47 µM 0.00140772334073539 0.461692617386637 no 1528 0.499438399825758 546 17014901
SGTC_3279 9140807 49.47 µM 0.00137211585669119 0.461707363449622 no 1529 0.49945260514292 546 45595718
SGTC_2806 7952793 58.44 µM 8.15675315989965e-05 0.462241851263087 no 1530 0.499967459262973 547 2972490
SGTC_1695 st026914 34.495 µM -7.22775546940987e-05 0.462305571634582 no 1531 0.499971165427534 549 3289191
SGTC_2105 5350118 200 µM -0.000723101117209853 0.462575143863154 no 1532 0.499711524416479 549 2133313
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0011059658072738 0.462733735108722 no 1533 0.499558783568747 547 688664
SGTC_863 0466-0191 129 µM -0.00128190680081786 0.462806615850187 no 1534 0.499488593317684 551 765160 YPR165W RHO1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.00138964833379648 0.462851246672867 no 1535 0.499445610703191 550 16486 A toxic proline analog.
SGTC_3027 9089541 49.47 µM -0.00253044157152966 0.463323837126892 no 1536 0.498990500946358 550 9943819
SGTC_2531 methyl deoxycholate 70.07 µM -0.00314680765827533 0.46357919746723 no 1537 0.498744607448723 550 16667744 Haematoxylin.
SGTC_3077 9117319 49.47 µM -0.00446850633924308 0.464126827409862 no 1538 0.498217329823628 549 17154678
SGTC_705 1124-0212 310 µM -0.00507700880360813 0.464378975995896 no 1539 0.497974575231505 550 9554485
SGTC_2814 7977482 42.97 µM -0.00675898325580273 0.465076019321108 no 1540 0.497303576337255 557 6456762
SGTC_2254 7938975 95.19 µM -0.00684041899470772 0.465109770631912 no 1541 0.497271088928931 555 2969277
SGTC_24 0417-1663 219 µM -0.00721880153933981 0.465266595815354 no 1542 0.497120139864263 553 4329390
SGTC_1994 st072947 40.9 µM -0.0074302273449814 0.465354226126981 no 1543 0.497035795433889 551 5286565 YDL195W SEC31
SGTC_1213 1315-0166 115 µM -0.0076123196408448 0.465429699834303 no 1544 0.496963153172933 557 768401
SGTC_326 k292-0812 17.5 µM -0.00765094720255601 0.465445710365679 no 1545 0.49694774345413 553 3579357
SGTC_140 0062-0056 502.533 µM -0.00806881578595671 0.465618914048996 no 1546 0.496781043159036 552 3758964
SGTC_263 alizarin 107.927 µM -0.0089064015916561 0.46596610724225 no 1547 0.49644690681317 554 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_170 4197-0004 226 µM -0.00951178583700249 0.466217065184758 no 1548 0.496205403686344 554 218692
SGTC_287 k060-0039 29.6 µM -0.00957178093375092 0.46624193647938 no 1549 0.496181470195183 551 5861974
SGTC_1662 st014054 52 µM -0.00976933853012433 0.466323835989905 no 1550 0.496102659802553 552 2838777
SGTC_1114 scopoletin 1.73284 µM -0.010021511956516 0.466428379119616 no 1551 0.496002062086394 552 5280460 A coumarin with genotoxic properties.
SGTC_2908 7930301 100 µM -0.0102494433503583 0.466522874262336 no 1552 0.495911135287037 551 2223178
SGTC_3012 9080433 71.4286 µM -0.0108050101306282 0.466753207437667 no 1553 0.495689508492609 556 17688859
SGTC_1509 1326-1131 80 µM -0.0111897001570621 0.466912703119734 no 1554 0.495536048657298 547 768313
SGTC_1468 k284-1086 134 µM -0.0112889962420521 0.466953872965536 no 1555 0.495496437752696 553 15996457
SGTC_1594 piperine 70.1 µM -0.0133507066223901 0.467808772385901 no 1556 0.494673996874576 553 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1148 3909-7663 27.7 µM -0.0135270461632268 0.467881899484577 no 1557 0.494603653928496 567 4084526
SGTC_846 0335-0850 148 µM -0.0143130314093434 0.46820785666245 no 1558 0.494290121567777 556 6819598
SGTC_2975 9084847 53.72 µM -0.0158308174471405 0.468837360229676 no 1559 0.493684681373487 553 27211724
SGTC_519 k048-0011 62.8 µM -0.0162894004196179 0.469027573462957 no 1560 0.493501756830415 557 6836379
SGTC_2274 7947094 46.08 µM -0.0171816639850346 0.469397691022424 no 1561 0.493145845025744 557 2971028
SGTC_2917 7979103 53.79 µM -0.0171853475296723 0.469399219039153 no 1562 0.493144375720985 558 2980565
SGTC_2235 salicylic acid 500 µM -0.0177315323869646 0.469625793713615 no 1563 0.492926512695746 554 338 A COX inhibitor and kinase inhibitor.
SGTC_568 1193-0097 7.48 µM -0.0181110337700441 0.469783228630914 no 1564 0.492775137860133 560 3646150
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0201260557613789 0.470619232506724 no 1565 0.491971407430497 568 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1621 st003705 32.4 µM -0.021006444763732 0.47098453421287 no 1566 0.491620257316545 560 24207032
SGTC_1702 st027038 51 µM -0.0212292019518815 0.471076967215573 no 1567 0.491531409869635 560 5521182
SGTC_3189 9110682 49.47 µM -0.0217205991552196 0.471280877783812 no 1568 0.491335415949326 565 17122418
SGTC_935 2996-0153 430 µM -0.0227394415891458 0.471703681365884 no 1569 0.490929057061301 560 23738523
SGTC_2299 7976368 114.88 µM -0.0230664723996374 0.471839400791574 no 1570 0.490798624857878 559 2979718
SGTC_2621 lithochol-11-enic acid 100 µM -0.0245231737936919 0.472443978676612 no 1571 0.490217649628736 560 6708711
SGTC_55 0767-0285 6.563 µM -0.0252531706576528 0.47274697480006 no 1572 0.489926513203593 561 3116166
SGTC_3132 9126706 49.47 µM -0.0258820638076802 0.473008018965836 no 1573 0.489675703131378 564 850858
SGTC_768 0384-0033 77.3 µM -0.0260905129527385 0.473094545660189 no 1574 0.489592572027675 561 3965305 YMR134W ERG29
SGTC_2174 5790901 200 µM -0.0267312412830476 0.473360518243481 no 1575 0.489337047544938 563 786020
SGTC_1473 k844-0725 134 µM -0.0271838910112282 0.473548424729294 no 1576 0.489156532034859 558 54682906
SGTC_2960 9079389 5.97 µM -0.0277062467253561 0.473765275266173 no 1577 0.488948220725579 567 16457355
SGTC_1705 st027868 56.3335 µM -0.0278716152787493 0.473833927922767 no 1578 0.488882273685739 568 292948
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0298863522216341 0.474670406566423 no 1579 0.488078845168992 566 6708561
SGTC_1921 5740136 50 µM -0.0301141772126457 0.474765002060555 no 1580 0.487987997039322 564 1774243
SGTC_1516 st013856 110 µM -0.0310697711832337 0.475161790841993 no 1581 0.487606948563479 574 5281404 A mutagen and neurotoxin.
SGTC_2754 granisetron 64.02 µM -0.0315827622034216 0.475374808947165 no 1582 0.48740239515064 570 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2466 5983409 37.09 µM -0.0323556551843525 0.475695763896558 no 1583 0.487094212995984 577 2879657
SGTC_1671 st016596 74.5 µM -0.0330034117997861 0.47596476632256 no 1584 0.486835933451086 562 2829167
SGTC_369 0957-0393 4.5 µM -0.0332091117295009 0.476050192340739 no 1585 0.486753916011074 578 6997992
SGTC_2475 5812728 15.03 µM -0.0335363806797108 0.476186107553351 no 1586 0.486623427275865 566 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1999 st074831 12.5 µM -0.0343885843586711 0.476540041790129 no 1587 0.486283643225603 578 17112523
SGTC_1844 rapamycin 4 nM -0.034434650706598 0.476559174433639 no 1588 0.486265276289623 573 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1458 k015-0034 6.33 µM -0.0347946950720385 0.47670871279308 no 1589 0.486121725395557 584 3598957
SGTC_3264 9137442 49.47 µM -0.0350143948633944 0.476799963011599 no 1590 0.486034131235398 569 17015726
SGTC_1950 st077106 7.18 µM -0.0350569723394634 0.476817647302155 no 1591 0.486017155701927 560 13831864
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.035552049087798 0.477023277701125 no 1592 0.485819771705868 575 4174840
SGTC_329 k048-0121 21.3 µM -0.0355800161399838 0.477034894014672 no 1593 0.485808621520696 577 6832902
SGTC_2744 captopril 92.04 µM -0.035707820971937 0.477087978906576 no 1594 0.485757667148391 564 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_293 4049-0273 38.5 µM -0.0358904140697173 0.47716382130495 no 1595 0.485684869704386 562 1380311
SGTC_244 nsc-207895 1.295 µM -0.0376515762267675 0.477895384782306 no 1596 0.48498274258364 567 42640
SGTC_2076 5212012 200 µM -0.0390296561657618 0.478467873043385 no 1597 0.484433372210077 566 604802
SGTC_2982 9019404 25.97 µM -0.0392254098808779 0.478549197576813 no 1598 0.484355337533699 575 22333232
SGTC_1193 1488-0126 41.5 µM -0.0397732328664273 0.478776791601387 no 1599 0.484136958209098 557 1384710
SGTC_219 mitoxanthrone 164.414 µM -0.0408324966478439 0.479216884168475 no 1600 0.483714716187883 573 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_3328 9140624 29.0385 µM -0.0410905411652393 0.479324097842226 no 1601 0.483611857646557 560 4904392
SGTC_660 4031-1742 102 µM -0.0438432322788801 0.4804678917605 no 1602 0.482514682911181 562 6738706
SGTC_2361 9034121 116 µM -0.0440889457924171 0.480569998214271 no 1603 0.482416752098729 586 6496917
SGTC_2779 methotrexate 400 µM -0.0441580497514194 0.480598714651558 no 1604 0.482389210431002 576 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2849 9019321 12.99 µM -0.0446067793361922 0.480785188537942 no 1605 0.482210369455799 565 16489627
SGTC_224 benfluorex 43.875 µM -0.046081833732508 0.481398190960513 no 1606 0.481622512603253 564 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3289 9119912 71.43 µM -0.0460866846752452 0.481400206986407 no 1607 0.481620579411003 583 17014829
SGTC_2867 9039098 71.43 µM -0.0461388680077795 0.48142189413079 no 1608 0.481599783395283 581 6463460
SGTC_3037 9091026 49.47 µM -0.0463574455076207 0.481512734495072 no 1609 0.481512676794861 580 25236398 YIL048W NEO1
SGTC_2067 5224629 34.075 µM -0.046666787558083 0.481641298061438 no 1610 0.481389400590914 572 2835000
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.047556182287058 0.482010944004973 no 1611 0.481034976979738 571 641818 YHR062C RPP1
SGTC_1682 st012968 530 nM -0.0493141367840765 0.482741621757601 no 1612 0.480334476850325 577 24207270
SGTC_1747 st037496 66.6 µM -0.0495068532987159 0.482821726189289 no 1613 0.480257687878042 570 723305
SGTC_2526 patulin 37.61 µM -0.0504568046903168 0.483216592490764 no 1614 0.479879185197743 574 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2514 salinomycin 42.74 µM -0.0506246995602399 0.483286383075436 no 1615 0.479812290327175 586 23682228 A polyether potassium ionophore.
SGTC_727 3032-0951 202 µM -0.0506806456337001 0.483309638868152 no 1616 0.479789999686874 584 3652836
SGTC_1135 dihydrocapsaicin 536.708 nM -0.0506955387666793 0.483315829689556 no 1617 0.479784065814238 593 107982 A Capsaicinoid.
SGTC_186 3455-3465 67.277 µM -0.0507286323766313 0.483329586153258 no 1618 0.479770880339568 568 755278
SGTC_739 1486-1183 203 µM -0.0517789036965298 0.483766176709023 no 1619 0.479352432704732 575 4346692
SGTC_731 3966-0296 387 µM -0.0519701260370878 0.483845668629212 no 1620 0.47927624860162 582 660956
SGTC_2094 5332512 191.667 µM -0.0526799256799074 0.484140740875231 no 1621 0.478993466899695 575 755774
SGTC_3059 1327-0034 3 µM -0.0528124313203804 0.484195826030085 no 1622 0.47894067828163 579 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3147 9097027 49.47 µM -0.05284176464691 0.48420802050148 no 1623 0.47892899229489 573 25236841
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0534885816841576 0.484476919474307 no 1624 0.478671314061344 572 7104
SGTC_923 1900-2434 73.3 µM -0.0551101343981045 0.485151072647286 no 1625 0.478025361167092 569 5910570
SGTC_1090 efavirenz 20.7 µM -0.0574791578719291 0.48613605916217 no 1626 0.477081754132128 574 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3137 9097352 49.47 µM -0.0583421884172273 0.486494909129896 no 1627 0.476738031614313 575 44120435
SGTC_783 0848-0141 92.7 µM -0.0587397958803227 0.486660238870445 no 1628 0.476579680757901 570 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1223 0764-0573 147 µM -0.0588603329878298 0.486710360035541 no 1629 0.476531676467319 572 1609797
SGTC_2610 ononetin 44.17 µM -0.0590247591812439 0.486778731289329 no 1630 0.476466193756484 584 259632
SGTC_2128 5255449 168.493 µM -0.0592485961139156 0.486871807179798 no 1631 0.476377051748005 576 736008
SGTC_936 3005-4620 401 µM -0.059782332834218 0.487093748499826 no 1632 0.476164498381369 562 777207
SGTC_1949 st076024 69.1 µM -0.0601241330974745 0.487235879857203 no 1633 0.476028384648444 570 2921930
SGTC_2787 5284540 71.43 µM -0.0604983659717403 0.487391499578431 no 1634 0.475879358616804 585 736958
SGTC_1308 1187-1617 41.4 µM -0.0605573322887403 0.487416020106138 no 1635 0.475855877512185 572 2882570
SGTC_1176 0848-0131 83.3 µM -0.0606204100112322 0.487442250371584 no 1636 0.475830759288715 573 6769040
SGTC_1488 4013-0813 75.9 µM -0.0668146161333648 0.490018298225634 no 1637 0.473364643709911 576 2910057
SGTC_1068 loratadine 26.9 µM -0.0669469829154298 0.49007335188016 no 1638 0.473311954975381 594 3957 A H1 histamine antagonist.
SGTC_76 0433-0009 400.328 µM -0.066961791753892 0.49007951114628 no 1639 0.473306060330934 627 2841569
SGTC_2976 9009005 19.48 µM -0.0669800104429592 0.490087088634728 no 1640 0.473298808406629 569 2993148
SGTC_1856 st057054 55.7 µM -0.0677701541656699 0.490415727372013 no 1641 0.472984301323916 584 1266018
SGTC_3190 9110366 49.47 µM -0.0683874981138273 0.490672499293716 no 1642 0.47273858679544 589 17123768
SGTC_1769 st044406 64.4 µM -0.0688120402134248 0.49084908137548 no 1643 0.472569617051232 571 670903
SGTC_1081 sertraline 6 µM -0.0704031416090647 0.491510892421956 no 1644 0.471936395406486 576 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2358 9037157 4 µM -0.0740116292649898 0.493011909422431 no 1645 0.470500565912912 579 2388925
SGTC_625 k213-0058 121 µM -0.0748622627100807 0.493365761295213 no 1646 0.470162151130913 580 3655420
SGTC_808 0711-0032 135 µM -0.0754070753448955 0.493592398655905 no 1647 0.469945414964364 582 4252555
SGTC_3124 9127567 49.47 µM -0.0782306679992635 0.494767020368913 no 1648 0.468822283614752 611 17592030
SGTC_1014 4130-3005 69.3 µM -0.0795624513499777 0.495321061993653 no 1649 0.468292629993521 599 743608
SGTC_1017 4239-0030 168 µM -0.0795744864444221 0.495326068814185 no 1650 0.468287843860347 572 1149593
SGTC_1888 azatryptophan 97.5 µM -0.0799162763826497 0.495468260016004 no 1651 0.468151922276283 590 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2203 7227154 166.4 µM -0.0805565959969538 0.495734646852316 no 1652 0.467897292672246 580 896304
SGTC_1329 1447-1697 50.6 µM -0.0812279263007903 0.496013936847803 no 1653 0.46763034545754 591 2840515
SGTC_2091 4-phenylthiadiazole 200 µM -0.0819790635517801 0.4963264308149 no 1654 0.467331681136397 586 270010
SGTC_677 0929-0063 136 µM -0.0828550320077058 0.496690860865503 no 1655 0.46698340514951 572 1539583
SGTC_3344 9148862 3.898 µM -0.0828927955074117 0.496706571717094 no 1656 0.466968391339516 606 4905352
SGTC_2204 7233102 200 µM -0.0837739335206745 0.497073155362146 no 1657 0.466618086593428 599 2172480
SGTC_562 3772-2733 112 µM -0.0841440500462765 0.497227137290284 no 1658 0.466470950966277 593 2876874 YIL048W NEO1
SGTC_3052 9092717 49.47 µM -0.0841908207952018 0.497246595651798 no 1659 0.466452358111174 599 25237534
SGTC_2391 6285546 200 µM -0.0843275268780538 0.497303470476146 no 1660 0.466398013530206 574 846083
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0852807106592317 0.497700031905594 no 1661 0.46601911316197 584 688761
SGTC_2892 9047358 58.44 µM -0.085579602932493 0.497824383172599 no 1662 0.465900306732494 599 6466771
SGTC_500 h-89 112 µM -0.0857012163441826 0.497874979328703 no 1663 0.465851967592553 602 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_651 3253-0966 34.4 µM -0.0859987228285061 0.49799875434361 no 1664 0.465733716250654 590 781462
SGTC_1506 4226-2149 212 µM -0.0860221747079225 0.498008511304754 no 1665 0.465724394847172 611 991114
SGTC_2471 5466956 24.79 µM -0.0860430715889182 0.498017205280866 no 1666 0.465716088993119 580 724419
SGTC_1734 st037168 69.4 µM -0.0870835120527249 0.498450073116377 no 1667 0.465302565534108 613 708907
SGTC_2004 4023728 41.89 µM -0.0871572177328544 0.498480737914194 no 1668 0.465273272599281 582 360084 YDR527W RBA50
SGTC_2451 5856223 45.7 µM -0.0877849747596508 0.498741912734493 no 1669 0.465023790031096 578 2179896
SGTC_2856 9022925 19.48 µM -0.0879736949028853 0.498820428811208 no 1670 0.464948791744292 595 4944862
SGTC_2736 butenafine 14.65 µM -0.0881885123907183 0.498909802613744 no 1671 0.464863423763502 585 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3030 9087619 49.47 µM -0.0882717396852818 0.498944428952022 no 1672 0.464830349860495 588 25236973
SGTC_638 3970-0837 4.09 µM -0.0885580459316991 0.499063545425905 no 1673 0.464716575761308 582 4118451 YLR208W SEC13
SGTC_3065 9113888 49.47 µM -0.0891392575870797 0.499305356263557 no 1674 0.464485619257669 615 16648368
SGTC_205 1486-1330 71.903 µM -0.0893610315937284 0.499397624544352 no 1675 0.464397495906933 588 4118834
SGTC_87 0100-0052 35.5 µM -0.0896144365576194 0.499503052810723 no 1676 0.464296805926689 584 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2834 9001755 58.44 µM -0.0901394824082708 0.499721496438727 no 1677 0.464088187241078 629 2989575
SGTC_538 2922-0838 53.3 µM -0.0907618982853335 0.499980450654214 no 1678 0.463840892905537 602 777039
SGTC_1056 3448-1962 115 µM -0.0908558749145422 0.499980450654214 no 1679 0.463803555917735 597 715507
SGTC_682 0kpi-0099 17 µM -0.0909180981115373 0.499954562881894 no 1680 0.46377883476862 601 1714895 YML126C ERG13
SGTC_1977 st070720 65.3 µM -0.0914602253364477 0.499729012514777 no 1681 0.463563454656764 613 682188
SGTC_138 0850-0259 40.9225 µM -0.0931920207138051 0.499008505299771 no 1682 0.46287550667571 602 6813004
SGTC_818 4072-2707 53.5 µM -0.0932841435125995 0.49897017801171 no 1683 0.462838914397035 582 882871
SGTC_2810 7959871 45.46 µM -0.0947747872400416 0.498350003769891 no 1684 0.462246856788223 600 2974535
SGTC_927 2425-1185 123 µM -0.0950928505914642 0.4982176757021 no 1685 0.462120538372401 609 730375
SGTC_2306 7482397 179.52 µM -0.0958556918528449 0.49790030167358 no 1686 0.461817592624755 605 891448
SGTC_2807 7945238 51.95 µM -0.0960178231218807 0.497832848415388 no 1687 0.461753208580345 610 17148797
SGTC_2355 9061122 103.12 µM -0.096560853081729 0.497606926140445 no 1688 0.461537572940799 603 5302957
SGTC_2028 5153890 36.43 µM -0.0966666852268293 0.497562895804268 no 1689 0.461495548614074 609 2830968 YPR165W RHO1
SGTC_2345 9052315 157.45 µM -0.0968212708892433 0.497498582140251 no 1690 0.461434165783781 593 6469265
SGTC_2286 7945697 125 µM -0.0969363112924869 0.497450720888313 no 1691 0.461388486169773 605 1245733
SGTC_1503 4585-0012 61.3 µM -0.0974139384073984 0.497252009957194 no 1692 0.46119883806237 609 2922052
SGTC_794 k038-0031 316 µM -0.0987744197467029 0.496686002205704 no 1693 0.46065868961814 585 6624242
SGTC_2907 7721985 69.9 µM -0.098851249751626 0.496654038428708 no 1694 0.460628188152648 601 3267881
SGTC_393 acivicin 6.25 µM -0.0988781458118189 0.496642848799321 no 1695 0.46061751048775 608 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_899 1083-0020 478 µM -0.0994009309404008 0.496425353842915 no 1696 0.460409971821202 603 767123
SGTC_492 tmb-8 126 µM -0.101683968792659 0.495475552027726 no 1697 0.45950376361651 618 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2647 atorvastatin 60.16 µM -0.101727731799008 0.495457345737311 no 1698 0.45948639476805 605 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_958 1222-0007 33 µM -0.101797582309716 0.49542828654026 no 1699 0.459458672359902 615 7312461
SGTC_2406 ethylparaben 405.7 µM -0.103427000405076 0.49475042352258 no 1700 0.458812041914524 650 8434 A possible steroid mimic.
SGTC_2699 st077704 54.6 µM -0.104432606315072 0.494332083418837 no 1701 0.458413024022742 600 645852
SGTC_2137 5261020 140 µM -0.104584426819608 0.494268925404591 no 1702 0.458352786263678 602 763655
SGTC_2869 9037858 32.47 µM -0.104641749765376 0.494245078838034 no 1703 0.458330042510757 584 27187042
SGTC_943 3253-1379 105 µM -0.106862193275607 0.493321382424172 no 1704 0.45744915339324 595 668464
SGTC_2376 9072922 81.32 µM -0.106886621651785 0.493311220498711 no 1705 0.457439463379808 636 17087968
SGTC_2634 4'-methoxyflavone 100 µM -0.10763658241444 0.492999247531712 no 1706 0.457141988493189 609 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_954 1189-0853 2.85 µM -0.10787228568818 0.492901199211292 no 1707 0.457048500813951 603 2828194
SGTC_2653 dihydrofissinolide 100 µM -0.109367302270842 0.492279309448451 no 1708 0.456455583576867 588 6857746
SGTC_60 0986-0278 202 µM -0.109873881198543 0.492068589378751 no 1709 0.456254698445225 596 3110598
SGTC_1906 st060206 94.7 µM -0.110369588954651 0.491862393498888 no 1710 0.456058135126894 590 5133468
SGTC_2752 diclazuril 33.15 µM -0.111699814386099 0.491309080388792 no 1711 0.455530713254239 616 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2881 9058953 51.95 µM -0.111957981356181 0.491201696608392 no 1712 0.455428361529914 580 17122249
SGTC_3148 9097893 49.47 µM -0.112180632832782 0.491109085903299 no 1713 0.455340092495175 593 17174100
SGTC_3122 9126309 49.47 µM -0.112192843524419 0.491104006944457 no 1714 0.4553352516929 594 17591206
SGTC_220 paclitaxel 373.376 µM -0.11396859404764 0.490365410686307 no 1715 0.454631344756269 627 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3221 9128209 49.47 µM -0.114883739414502 0.489984782713961 no 1716 0.454268636908881 604 16460723
SGTC_3047 9092122 49.47 µM -0.115436219360568 0.489754999218232 no 1717 0.45404968597033 620 17173831
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.115571897250899 0.489698569560547 no 1718 0.453995918185365 660 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_598 3937-0236 20.2 µM -0.11563810668958 0.489671032532934 no 1719 0.45396968035597 587 1379313
SGTC_2383 9036125 200 µM -0.116168214305335 0.489450558381808 no 1720 0.453759613735978 597 79580
SGTC_1725 st036284 20.55 µM -0.116330338674203 0.489383130765272 no 1721 0.453695371025077 614 707914
SGTC_352 k048-0007 5.11 µM -0.119207157148354 0.488186712587522 no 1722 0.452555618250143 620 6811911
SGTC_930 2810-3379 265 µM -0.119544943795624 0.488046239831025 no 1723 0.452421817652218 647 1015764
SGTC_2140 5586273 200 µM -0.12074164180112 0.487548590211383 no 1724 0.451947837435713 590 854421
SGTC_3211 9128781 49.47 µM -0.121392582795087 0.487277902992417 no 1725 0.451690045753474 630 17194361
SGTC_585 0kpi-0023 191 µM -0.121579753460325 0.48720007104654 no 1726 0.451615924458705 602 64601
SGTC_405 ebelactone b 50 µM -0.123635022253912 0.486345452906287 no 1727 0.450802130732863 591 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_167 3672-0051 66.205 µM -0.124052781775203 0.486171748441119 no 1728 0.450636741982977 610 3237971
SGTC_236 1509-0011 5.31 µM -0.125477517171582 0.485579363202447 no 1729 0.45007276152553 625 3107280
SGTC_658 3253-0951 102 µM -0.127536121691518 0.484723480514324 no 1730 0.449258042809398 618 1184878
SGTC_2197 6588183 93.1375 µM -0.12755270697601 0.484716585318902 no 1731 0.449251479837695 610 884136
SGTC_3278 9139605 49.47 µM -0.127641349953884 0.484679732808504 no 1732 0.449216403113463 640 7958859
SGTC_7 0192-1582 4.227 µM -0.12789509125005 0.484574242901036 no 1733 0.449115997879801 600 252616
SGTC_2478 5763493 32.33 µM -0.128157089625521 0.484465321344645 no 1734 0.449012328745444 596 1365576 YLR208W SEC13
SGTC_2575 plumbagin 510 nM -0.12909018428075 0.4840774119146 no 1735 0.44864314441516 614 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1043 0916-0009 19.3 µM -0.129984727010758 0.483705543571774 no 1736 0.448289255123314 590 3101130
SGTC_445 e6 berbamine 66 µM -0.131688733326181 0.482997214428676 no 1737 0.447615248703025 612 6610268 A calcium/calmodulin antagonist.
SGTC_641 4092-0595 30 µM -0.131828231690719 0.482939229456189 no 1738 0.447560077882789 601 786260
SGTC_1249 0481-0015 10.2 µM -0.132433317928734 0.482687718809111 no 1739 0.447320781430119 598 4227577
SGTC_3219 9131112 49.47 µM -0.13257254840074 0.482629847127126 no 1740 0.447265721976055 596 17612988 YMR079W SEC14
SGTC_795 0685-0265 78 µM -0.133237495305729 0.482353464453729 no 1741 0.447002779109373 606 302754
SGTC_362 0310-0100 9.03 µM -0.133241326766275 0.482351871946048 no 1742 0.447001264085539 613 790235
SGTC_2720 fluspirilene 36.88 µM -0.134575260127287 0.481797453378833 no 1743 0.446473851598932 618 3396 An atypical antipsychotic.
SGTC_1357 1503-1303 39.5 µM -0.135123968519171 0.481569405576529 no 1744 0.446256929915337 603 292895
SGTC_1565 sinapyl alcohol 95.1 µM -0.135726733655337 0.481318898292787 no 1745 0.446018656440567 606 5280507 A phenol propionate derived from cinnamic acid.
SGTC_980 1473-0395 201 µM -0.135816166633946 0.481281730855826 no 1746 0.445983305180912 592 768876
SGTC_2836 9010338 19.48 µM -0.135922769916616 0.481237427827597 no 1747 0.445941167367614 604 2994051
SGTC_3301 9125354 19.7965 µM -0.13645780993114 0.481015075213612 no 1748 0.445729687650196 608 41905162
SGTC_2722 naftopidil 47.16 µM -0.136803214744291 0.480871534572203 no 1749 0.445593171269286 639 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1768 st044301 37.178 µM -0.137334449131959 0.480650773170888 no 1750 0.445383220965347 612 3931349
SGTC_3100 9120536 49.47 µM -0.138137690515358 0.480316986994778 no 1751 0.445065799289161 654 16421196
SGTC_2344 7990960 76.95 µM -0.138273510436492 0.480260548516226 no 1752 0.445012129998412 622 140813
SGTC_2988 9073640 71.4286 µM -0.138734374482752 0.48006904447267 no 1753 0.444830026922836 627 9102229
SGTC_2951 9072950 58.06 µM -0.138771126826703 0.48005377287245 no 1754 0.444815505321206 593 16488155
SGTC_2555 cholic acid 100 µM -0.139085641169249 0.47992308479389 no 1755 0.444691237312446 601 6708657 Influences liver metabolism.
SGTC_1416 3966-0321 25.3 µM -0.139278837200127 0.479842808385471 no 1756 0.444614906171375 626 582530 YLR208W SEC13
SGTC_2934 9036370 36.88 µM -0.140136625237965 0.479486392022601 no 1757 0.444276021672353 613 6462800
SGTC_1257 0669-0121 16 µM -0.140307677078157 0.47941532085191 no 1758 0.444208449448468 600 4307855
SGTC_1206 3978-0017 132 µM -0.140630108649069 0.479281353953412 no 1759 0.444081080671021 651 3873677
SGTC_1261 0712-0010 12.7 µM -0.141348183033122 0.478983010094287 no 1760 0.443797443561206 621 2840123
SGTC_2900 5328528 85.29 µM -0.141646885640061 0.47885890929482 no 1761 0.443679465446362 599 795359
SGTC_330 1488-0319 80.1 µM -0.142703041066953 0.478420129062489 no 1762 0.443262357438823 608 6846614
SGTC_411 enrofloxacin 100 µM -0.142897871296298 0.478339189600426 no 1763 0.443185419889832 618 71188 A bacterial gyrase inhibitor.
SGTC_1015 4130-4525 82 µM -0.143297070282525 0.47817335082412 no 1764 0.443027784765591 622 1363237
SGTC_245 methotrexate 289.6 µM -0.143796823653564 0.477965744185594 no 1765 0.442830455582883 601 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2972 9093619 59.92 µM -0.144123168235108 0.477830177935216 no 1766 0.442701605053711 602 25236256
SGTC_1957 st077035 62.4 µM -0.144436159508304 0.477700161169826 no 1767 0.442578032500238 615 705593
SGTC_3029 9088683 49.47 µM -0.144566968229231 0.477645823849987 no 1768 0.442526389367677 618 25236615
SGTC_916 4466-0038 42 nM -0.14458909457028 0.477636632714332 no 1769 0.442517654010224 624 5722064 YGL116W CDC20
SGTC_2096 5468907 200 µM -0.145099564680027 0.477424590121467 no 1770 0.442316130993615 598 759785
SGTC_1335 1486-0900 202 µM -0.145196570335759 0.477384295964357 no 1771 0.442277836857939 594 X1335
SGTC_738 1315-0003 72.4 µM -0.145506651994139 0.477255495964623 no 1772 0.442155432056792 642 6251474
SGTC_2030 5175110 200 µM -0.146144853935381 0.476990410673405 no 1773 0.441903519096885 650 2831986
SGTC_1170 0310-0127 64.8 µM -0.146413158903145 0.476878969826631 no 1774 0.441797619974754 641 774975
SGTC_3355 9151058 44.0485 µM -0.146973956699611 0.476646047520549 no 1775 0.44157628830149 599 17015728
SGTC_3102 9121669 49.47 µM -0.148187170894052 0.476142177355902 no 1776 0.441097528089333 607 41905072
SGTC_1807 st050092 58.9 µM -0.148890683935765 0.475850012874758 no 1777 0.440819946208741 643 5008496
SGTC_1786 berberine 21.6 µM -0.149584895741635 0.475561723864115 no 1778 0.440546062773258 644 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1428 4049-0204 61.7 µM -0.150196230058479 0.475307862415318 no 1779 0.440304900067314 614 X1428
SGTC_71 0417-1750 47.813 µM -0.151310938520693 0.474844996714077 no 1780 0.439865220469245 596 6811472
SGTC_3225 9130819 49.47 µM -0.152989650146567 0.474148001553707 no 1781 0.439203218596477 643 4547121
SGTC_996 3970-0799 1.8 µM -0.153808150138123 0.473808191799584 no 1782 0.4388805037146 622 6615648 YGL040C HEM2
SGTC_1344 1488-0097 29.1 µM -0.153907545798114 0.473766927832472 no 1783 0.438841317155874 605 747966
SGTC_146 3448-8650 53.125 µM -0.154071210758295 0.473698983170143 no 1784 0.438776793848454 654 2891488 YIL048W NEO1
SGTC_2791 5663188 71.43 µM -0.154608955719027 0.473475746526293 no 1785 0.43856480462906 635 54690634
SGTC_1294 1000-1494 117 µM -0.1550900176339 0.473276048043743 no 1786 0.43837517587048 604 712797 YDL207W GLE1
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.155364006763826 0.473162312640378 no 1787 0.438267179006996 652 689007
SGTC_443 clozapine 122 µM -0.15632099282579 0.47276507616646 no 1788 0.437890004933521 611 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2261 9010538 184.68 µM -0.157170323258343 0.47241254926831 no 1789 0.437555308099347 687 6457250
SGTC_1692 fluoroquinolonic acid 71 µM -0.157205987190157 0.472397746907654 no 1790 0.437541254939461 651 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1240 0356-0016 42.1 µM -0.158286155078199 0.471949439996501 no 1791 0.437115658629477 616 4305613
SGTC_1891 st059073 26.2 µM -0.159483076872651 0.471452717718471 no 1792 0.436644145184587 599 688754
SGTC_1453 4237-0541 195 µM -0.15951192517633 0.471440746223787 no 1793 0.436632781838344 611 739892
SGTC_2472 5377652 49.4 µM -0.159933075200759 0.471265979956376 no 1794 0.436466896810702 654 1610903
SGTC_1318 1280-3875 124 µM -0.160008787877214 0.471234561757695 no 1795 0.436437075844201 638 373245
SGTC_2700 st077718 96.8 µM -0.16180198623277 0.470490497883112 no 1796 0.4357308944338 621 904970
SGTC_2797 7859098 81.82 µM -0.163059805095807 0.469968643944869 no 1797 0.435235673524947 609 972681
SGTC_1404 3909-7820 48.3 µM -0.163404405918179 0.469825682165836 no 1798 0.435100017044346 621 23741373
SGTC_2957 9076800 11.52 µM -0.165345163861949 0.469020608653027 no 1799 0.434336156187858 650 16459615
SGTC_982 1491-0518 27.5 µM -0.165435693124161 0.468983057983429 no 1800 0.434300530832719 616 3091256
SGTC_578 3460-0051 92 µM -0.167142972957898 0.468274946721649 no 1801 0.433628777022215 639 2876744
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.168065077826099 0.467892536170338 no 1802 0.433266041189888 596 66535 A nucleotide analog.
SGTC_3131 9127911 49.47 µM -0.168742005906625 0.467611822903958 no 1803 0.432999788290562 661 45595681
SGTC_824 1304-0008 100 µM -0.169468016865784 0.467310773509972 no 1804 0.432714263658301 627 768245
SGTC_280 3448-3607 3.04 µM -0.17150652657178 0.466465580836508 no 1805 0.431912749507444 615 626179
SGTC_692 k241-0027 77.8 µM -0.171828678214167 0.466332026307963 no 1806 0.431786109439318 617 3600480
SGTC_746 1095-0025 46.6 µM -0.172144964563828 0.46620090704418 no 1807 0.431661781878462 624 6749286
SGTC_1459 k035-0031 35.7 µM -0.173326454989394 0.465711142448738 no 1808 0.431197415155804 612 3877128 YMR208W ERG12
SGTC_2521 angolensin 13.4 µM -0.173570718110959 0.465609894227165 no 1809 0.43110142311597 609 821428 A flavenoid.
SGTC_2882 9058044 58.44 µM -0.173652444863599 0.465576018597531 no 1810 0.431069306537056 641 18076804
SGTC_2597 laccaic acid a 100 µM -0.174428450697634 0.465254377680808 no 1811 0.430764378305674 646 5491415 A textile dye.
SGTC_1563 conessine 56.1 µM -0.175787536533921 0.464691115062722 no 1812 0.43023043078353 606 441082 An anti-amoebic, histamine inhibitor.
SGTC_3247 9135149 49.47 µM -0.176762433905473 0.464287119893665 no 1813 0.42984749887122 615 8934436 YOR116C RPO31
SGTC_2453 5731132 22.18 µM -0.178116092974658 0.463726227911182 no 1814 0.429315901876672 660 1362040
SGTC_1349 flufenamic acid 69 µM -0.179519759378698 0.463144691414251 no 1815 0.428764801803117 635 3371 A non-steroidal anti-inflammatory.
SGTC_1675 st018485 24.5 µM -0.179922667610656 0.462977781741925 no 1816 0.428606639707823 624 3323024
SGTC_3153 9100258 49.47 µM -0.18027809630452 0.462830546459911 no 1817 0.428467125277765 655 25236848
SGTC_1635 st007035 42.4 µM -0.181705168588535 0.462239437469467 no 1818 0.427907054777052 620 3716403
SGTC_941 3237-0776 460 µM -0.18182768524281 0.462188693595945 no 1819 0.427858978496714 620 760008
SGTC_1071 trifluoperazine 6.31 µM -0.183785762267752 0.461377782514012 no 1820 0.427090762972585 659 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1742 st038235 28.8875 µM -0.184204002203432 0.461204594803472 no 1821 0.426926709950978 625 564103 YBR002C RER2
SGTC_2211 7117706 200 µM -0.185169438454898 0.460804848372225 no 1822 0.426548069563025 612 822771
SGTC_332 4112-0506 40.9 µM -0.185460951914215 0.460684152710602 no 1823 0.426433752392832 625 2790355
SGTC_2703 st077852 53.4 µM -0.185816704987449 0.460536864753989 no 1824 0.426294251995422 654 6281836
SGTC_2765 myclobutanil 7.74 µM -0.186136767892208 0.460404357773645 no 1825 0.426168754557516 651 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1307 1187-1599 12.2 µM -0.18711312458743 0.460000170467544 no 1826 0.425785968981278 628 1538471
SGTC_2082 5219693 150 µM -0.187512601042594 0.459834809075651 no 1827 0.425629372355933 643 2834649
SGTC_2773 thioridazine 9.09 µM -0.188110175425315 0.459587458960454 no 1828 0.425395142327585 619 5452 An antipsychotic.
SGTC_1403 3909-7815 62.9 µM -0.188161026143077 0.459566411371179 no 1829 0.425375211688459 639 6615483
SGTC_2800 7887935 81.82 µM -0.188296107701045 0.459510500397206 no 1830 0.425322268194215 655 2961002
SGTC_1425 4048-4433 7.33 µM -0.188324833586011 0.459498610704129 no 1831 0.425311009623481 641 23734946
SGTC_581 0958-0271 211 µM -0.188489772603363 0.459430342863259 no 1832 0.425246366054651 633 4591145
SGTC_951 1171-0579 82.7 µM -0.189555076456537 0.458989445202059 no 1833 0.424828896328977 647 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1289 0976-0073 69.1 µM -0.190344573101688 0.458662728473925 no 1834 0.424519563888369 661 3391136
SGTC_2749 bexarotene 57.39 µM -0.190772285025201 0.458485740457726 no 1835 0.424352001609708 638 82146 An retinoic acid receptor inhibitor.
SGTC_42 0133-0086 60.653 µM -0.191685235657036 0.458107987306417 no 1836 0.423994385883076 649 162923 Model of phenazepam hydroxylation.
SGTC_3101 9120531 49.47 µM -0.191942360052128 0.458001603317523 no 1837 0.423893677887855 695 24824904
SGTC_144 4161-2749 112.381 µM -0.191956960139084 0.457995562691561 no 1838 0.42388795961612 626 797501 YMR168C CEP3
SGTC_1451 4152-0210 104 µM -0.192091299132045 0.457939981861081 no 1839 0.423835345142988 680 659563
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.193697324176114 0.457275576043074 no 1840 0.423206443581749 642 688669
SGTC_1019 4262-0212 3.4 µM -0.194567783788914 0.456915520329872 no 1841 0.422865662911401 629 4677213
SGTC_165 k038-0023 64.381 µM -0.194771090280568 0.456831429997113 no 1842 0.422786077721278 634 46368543
SGTC_2277 7947813 106.88 µM -0.194904761230927 0.456776142925284 no 1843 0.422733753376656 673 1246798
SGTC_3303 9125618 40.5795 µM -0.195253510844161 0.456631902026484 no 1844 0.422597244758215 650 22695467
SGTC_2636 apigenin dimethyl ether 100 µM -0.196839969527456 0.455975823945115 no 1845 0.421976385901768 673 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_974 1326-0144 138 µM -0.19851866352687 0.455281732783276 no 1846 0.421319641971365 659 5411856
SGTC_960 1222-0186 7.7 µM -0.198630210160651 0.455235616305901 no 1847 0.421276010081302 654 3126296
SGTC_758 0868-0029 16 µM -0.198702876770809 0.455205574234894 no 1848 0.421247586780336 623 762687
SGTC_1648 st011736 69.8 µM -0.198930338428167 0.455111537938722 no 1849 0.421158618569163 636 2855514
SGTC_2117 5521686 200 µM -0.199188358934711 0.45500487116939 no 1850 0.421057702596528 636 803312
SGTC_2903 5923464 63.88 µM -0.199429034162687 0.454905377935735 no 1851 0.420963575316511 651 2876576
SGTC_1568 digitonin 820 nM -0.19951309458334 0.454870628689618 no 1852 0.420930700630234 663 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2813 7971799 71.43 µM -0.19998151353749 0.454676998046434 no 1853 0.420747519570362 659 2234054
SGTC_3262 9137218 49.47 µM -0.20017705346815 0.454596170763448 no 1854 0.420671056321919 622 17650664
SGTC_1371 2421-0008 32.7 µM -0.200383615274881 0.454510789581869 no 1855 0.4205902863685 653 2827552
SGTC_1857 st056007 79.3 µM -0.203060067454228 0.453404684315291 no 1856 0.419544041504703 636 619834
SGTC_1379 2144-0755 36.5 µM -0.204118721538948 0.452967270489655 no 1857 0.419130362322925 634 5392327
SGTC_1210 3013-0140 750 nM -0.205696491237503 0.452315474954225 no 1858 0.418513999770548 660 905973
SGTC_2386 9075165 157.42 µM -0.205702653759855 0.452312929393294 no 1859 0.418511592745713 631 16452277
SGTC_3174 9107204 49.47 µM -0.206353551931439 0.452044073117231 no 1860 0.418257375074876 655 3938802
SGTC_1879 gemcitabine 100 µM -0.206430272333446 0.452012384873135 no 1861 0.418227413062465 636 60750 A nucleoside analog which inhibits DNA replication.
SGTC_463 ikarugamyin 104 µM -0.206794121206677 0.451862106564242 no 1862 0.418085323758714 640 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_111 0083-0039 52.457 µM -0.207370886941685 0.451623902627034 no 1863 0.417860108635036 618 759313
SGTC_2183 6420625 130.508 µM -0.207564190610393 0.451544072208681 no 1864 0.417784633562182 633 2897619
SGTC_188 3229-0966 278.469 µM -0.208188013853011 0.451286459489581 no 1865 0.417541083557969 635 5722370
SGTC_2023 5144124 124 µM -0.208852209032435 0.451012197413124 no 1866 0.417281806507745 628 2830192
SGTC_127 0180-0333 59.125 µM -0.208914488816705 0.450986481797733 no 1867 0.417257496643038 628 771601
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.209025071190803 0.45094082232316 no 1868 0.417214333455484 650 2374 Ca(2+)-ATPase inhibitor.
SGTC_3140 9094243 49.47 µM -0.209658575869205 0.450679260701112 no 1869 0.416967079285452 662 19291112
SGTC_1515 3460-0031 42.1 µM -0.210823975176727 0.450198146269987 no 1870 0.416512314751932 630 2876596
SGTC_2964 9083345 53.42 µM -0.212386711396535 0.449553113326081 no 1871 0.415902676037792 626 17741579
SGTC_1570 verbenone 133 µM -0.212402783734468 0.449546480018542 no 1872 0.415896407109863 669 29025 A natural terpanoid with antifungal properties.
SGTC_2594 a-mangostin 100 µM -0.212470095810831 0.449518699415412 no 1873 0.415870152633372 664 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_54 0159-0055 9 µM -0.213017782171042 0.449292671065467 no 1874 0.415656546408186 707 3319099
SGTC_2357 9067248 200 µM -0.213374013942726 0.44914566421772 no 1875 0.415517623830992 670 9150235
SGTC_1063 disulfiram 1.84 µM -0.213687131713339 0.44901645507117 no 1876 0.415395523487557 626 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2353 9059630 146.67 µM -0.21593069754331 0.448090798736726 no 1877 0.414520884164328 655 4779114
SGTC_924 2046-0044 21.3 µM -0.217996931988231 0.447238556086434 no 1878 0.413715750931969 639 3623589
SGTC_3087 9117406 49.47 µM -0.218165358349286 0.447169097339914 no 1879 0.413650137501968 635 42546093
SGTC_1053 3366-3204 134 µM -0.218696643045009 0.446950007056893 no 1880 0.413443182076895 643 3632071 YPR165W RHO1
SGTC_201 4262-0159 12.803 µM -0.218854667468998 0.446884844333367 no 1881 0.413381630241275 667 1341029
SGTC_2330 7979373 200 µM -0.219829198481131 0.446483019887333 no 1882 0.413002089354555 639 1863007
SGTC_3113 9123498 49.47 µM -0.221544396789499 0.445775932782203 no 1883 0.412334285831254 633 8897275
SGTC_260 nsc-65238 3.989 µM -0.222230129268406 0.445493289048555 no 1884 0.412067370352677 641 3246252
SGTC_439 amiodarone 34.4 µM -0.222467588828041 0.445395419929609 no 1885 0.411974950732956 646 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1602 st001878 87.6 µM -0.224611850498884 0.444511812433687 no 1886 0.411140622537761 694 595405 YLR310C CDC25
SGTC_1441 4106-0040 13 µM -0.226689704378132 0.443655833224453 no 1887 0.410332516721558 634 2904180
SGTC_697 0508-1955 564 µM -0.226741416705348 0.443634533484818 no 1888 0.410312409929235 654 6243113
SGTC_857 0438-0306 1.35 µM -0.228084890138217 0.443081228778665 no 1889 0.409790123225698 635 4686136
SGTC_3045 9092950 49.47 µM -0.228189816173942 0.443038020025984 no 1890 0.409749339063661 681 44120432
SGTC_843 0310-0051 143 µM -0.228274162637671 0.443003286473578 no 1891 0.409716554773887 643 2065037
SGTC_2459 5811157 9.22 µM -0.229419177116857 0.442531817313555 no 1892 0.409271566212379 639 2870684 YBR192W RIM2
SGTC_210 3551-0445 56.827 µM -0.229892482828824 0.442336953514172 no 1893 0.409087658868839 676 2865180 YOR207C RET1
SGTC_2390 9097792 176.6 µM -0.229948326304402 0.442313963221672 no 1894 0.40906596168514 648 4497149
SGTC_1062 mesoridazine 14.2 µM -0.230383251024767 0.442134915001465 no 1895 0.408896987445747 637 4078 A neuroleptic.
SGTC_3097 9117246 49.47 µM -0.231080663646249 0.441847831410517 no 1896 0.408626068397438 636 16423892
SGTC_912 3474-0017 2.18 µM -0.231145318260777 0.441821218468592 no 1897 0.408600954676716 680 3360550
SGTC_1477 0139-0234 16 µM -0.231650319425923 0.441613360422765 no 1898 0.408404810552244 637 620880
SGTC_2651 TUB2.036 5 µM -0.232560198676449 0.441238895524111 no 1899 0.408051468382267 647 15992207 YFL037W TUB2
SGTC_1092 toremifene 6.32 µM -0.234071525891374 0.440617018248366 no 1900 0.40746472548758 692 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2887 9044784 58.44 µM -0.234301849335715 0.440522258133418 no 1901 0.4073753251585 644 6465546
SGTC_154 3389-1638 511.116 µM -0.234687942974186 0.440363418388305 no 1902 0.407225473260524 710 5238686
SGTC_412 gemfibrozil 100 µM -0.235420596060695 0.44006202975141 no 1903 0.40694115094691 639 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_957 1187-1561 14.1 µM -0.235529089506687 0.440017402174391 no 1904 0.406899051818775 663 1538454
SGTC_399 oxolinic acid 75 µM -0.235713368267059 0.439941602894703 no 1905 0.406827547889944 647 4628 A DNA gyrase inhibitor.
SGTC_129 0088-0017 176.636 µM -0.236060673258105 0.439798752112579 no 1906 0.406692794893122 684 182446
SGTC_893 0958-0369 48.9 µM -0.236231033196134 0.439728683854516 no 1907 0.406626699931859 688 6819948
SGTC_2837 9008476 45.46 µM -0.236736027445925 0.439520993145758 no 1908 0.406430791714776 704 2992805
SGTC_106 0092-0003 11.579 µM -0.237022444878727 0.439403204664475 no 1909 0.406319688916952 654 1072148
SGTC_427 1354-0053 47.3 µM -0.237233379459733 0.439316461754374 no 1910 0.406237871128357 685 6813657
SGTC_1969 st069479 40.1 µM -0.237242529022298 0.439312699233419 no 1911 0.406234322267685 662 3895485
SGTC_2432 5630864 12.22 µM -0.237598391299213 0.439166364332995 no 1912 0.406096299173853 677 5714970
SGTC_1868 st057644 42.7 µM -0.238092384262193 0.438963242197112 no 1913 0.405904720698994 645 688665
SGTC_2206 7254556 146.969 µM -0.239281418986772 0.438474395824321 no 1914 0.405443686237556 645 4398905
SGTC_2118 5526350 200 µM -0.240097068212541 0.438139113195327 no 1915 0.405127503488544 672 743594
SGTC_1659 st012954 42.1 µM -0.241192342864935 0.43768895698412 no 1916 0.404703022628094 683 24207262
SGTC_2871 9038510 12.99 µM -0.244851646752305 0.436185576626827 no 1917 0.403285651225195 710 4945164
SGTC_3106 9121286 49.47 µM -0.245321538412635 0.435992593676013 no 1918 0.40310373798023 645 15943471
SGTC_112 phenothiazine 287.218 µM -0.246749308730013 0.435406306810083 no 1919 0.402551121652055 689 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2831 7999036 19.48 µM -0.246808669851685 0.435381934353466 no 1920 0.402528150227642 708 2988270
SGTC_1248 0469-0687 58.6 µM -0.247435287936743 0.435124672834723 no 1921 0.402285683606649 670 4017482
SGTC_2294 7971431 200 µM -0.248114247623355 0.434845953180721 no 1922 0.40202300610899 693 5741572
SGTC_650 1328-0195 38 µM -0.248621513326927 0.434637736723242 no 1923 0.401826782849268 673 2780821
SGTC_1313 1220-0047 237 µM -0.249442426394701 0.43430081641611 no 1924 0.401509285268867 654 3528706
SGTC_2246 7293507 91.5585 µM -0.250359466646744 0.433924499887469 no 1925 0.401154686274009 672 887656
SGTC_203 k066-0004 30.888 µM -0.25115983757533 0.43359610869296 no 1926 0.400845267219635 656 6795412
SGTC_1849 st056239 19.2 µM -0.251215334346266 0.433573340133676 no 1927 0.400823814772965 668 5393181
SGTC_2541 muurolladie-3-one 83.07 µM -0.251300335087278 0.433538467461649 no 1928 0.400790958056225 678 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_132 0417-1715 25.805 µM -0.252232281265294 0.433156158276098 no 1929 0.400430763845565 680 6769098
SGTC_1000 4048-0884 8.67 µM -0.253233374596682 0.432745552772577 no 1930 0.400043938804836 673 13040088
SGTC_217 ketoconazole 989 nM -0.253988200633624 0.432436003528358 no 1931 0.399752336898727 646 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_782 0083-0095 30.5 µM -0.254044265749955 0.432413013241092 no 1932 0.39973068023609 691 3591729 An indicator and reagent.
SGTC_2883 9059145 45.46 µM -0.254901458819932 0.432061537740984 no 1933 0.399399604751856 654 16476510
SGTC_3032 9089427 49.47 µM -0.255101927172157 0.43197934730326 no 1934 0.399322187865751 647 17173707
SGTC_894 0960-0238 55.9 µM -0.25540983076152 0.431853115003334 no 1935 0.399203289341296 675 6741907 YDL195W SEC31
SGTC_736 0958-0254 92.6 µM -0.256240421508519 0.431512629576392 no 1936 0.398882599194125 699 6812352
SGTC_278 4092-0821 23.9 µM -0.256337922046782 0.431472664352871 no 1937 0.398844958818455 688 877900
SGTC_669 0108-0021 26.2 µM -0.260315599246696 0.429842827157269 no 1938 0.397310170413316 755 17201
SGTC_892 0929-0076 29 µM -0.260365406942925 0.429822426171557 no 1939 0.39729096211494 639 5751038
SGTC_1275 0867-0008 21.1 µM -0.26040885008706 0.429804632227855 no 1940 0.397274208504391 675 3422836
SGTC_286 k060-0067 22.9 µM -0.261422618335759 0.429389441905109 no 1941 0.396883308211075 652 5985051
SGTC_3141 9094609 49.47 µM -0.261987553322223 0.429158105782004 no 1942 0.396665519073742 677 25236309 YDL196W YDL196W
SGTC_2737 bleomycin 30.5 nM -0.262507404390797 0.428945252636675 no 1943 0.396465138795943 661 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1085 doxorubicin 7.67 µM -0.263514508200394 0.428532952579951 no 1944 0.396077021337685 684 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2428 5615643 7.78 µM -0.264359581731158 0.428187046550004 no 1945 0.395751426525963 676 2253075
SGTC_3320 9137005 35.139 µM -0.265174202058813 0.427853657865746 no 1946 0.395437633744435 674 4908713
SGTC_614 0462-0418 107 µM -0.265510797969753 0.427715918815375 no 1947 0.395307996350622 656 5188303
SGTC_2947 9072639 7.68 µM -0.266971738208188 0.427118186992929 no 1948 0.394745460602597 684 16488146
SGTC_1606 st000094 49.2 µM -0.267873849310556 0.426749179023525 no 1949 0.394398211760951 683 1242210
SGTC_2994 9053520 71.4286 µM -0.268104971065149 0.426654649119961 no 1950 0.394309259756311 710 4647384
SGTC_2320 7373003 200 µM -0.268203816943309 0.426614221968622 no 1951 0.394271218550803 678 5415828
SGTC_1216 1165-0504 9.65 µM -0.268835059418157 0.42635606718748 no 1952 0.39402830632521 673 6304004
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.269379695451072 0.42613335658176 no 1953 0.393818754767678 677 390807
SGTC_898 1000-0849 28.3 µM -0.269491561561959 0.426087615608201 no 1954 0.393775717501097 671 6751807
SGTC_619 1652-1634 108 µM -0.269560751001566 0.426059325211487 no 1955 0.393749099504886 665 5400454
SGTC_306 1672-3436 11.6 µM -0.269672479102601 0.42601364227591 no 1956 0.393706117430367 690 6797378
SGTC_1201 1889-3372 45.9 µM -0.270174291333297 0.425808475566536 no 1957 0.393513085011653 663 5392199
SGTC_757 1066-0008 322 µM -0.270465886455099 0.425689265670519 no 1958 0.393400928955588 667 6842497
SGTC_2202 7226349 200 µM -0.270683774993425 0.42560019292756 no 1959 0.393317128391787 647 844334
SGTC_2826 7992541 19.48 µM -0.271598680364061 0.42522622148923 no 1960 0.39296530712154 700 2985066
SGTC_3080 9117754 49.47 µM -0.271615118497664 0.425219502946807 no 1961 0.39295898673626 689 9550191
SGTC_2273 7815444 169.05 µM -0.271677168151964 0.425194142402391 no 1962 0.392935129189498 739 2824616
SGTC_290 2043-6722 48.1 µM -0.272345895806495 0.424920843907685 no 1963 0.392678034824458 673 773758 YLR208W SEC13
SGTC_513 4245-1575 41.7 µM -0.272769612152961 0.424747696354125 no 1964 0.392515160020402 649 719745
SGTC_1836 st055642 81 µM -0.273805095716259 0.424324617251643 no 1965 0.392117203702975 694 8571
SGTC_1333 1482-0047 286 µM -0.2744204110815 0.424073252234885 no 1966 0.391880779543724 693 3811116
SGTC_1522 st012842 45.6 µM -0.277533107679058 0.422802147072342 no 1967 0.39068539379969 679 3491067 YOR116C RPO31
SGTC_1878 temozolomide 1 mM -0.277584009179975 0.422781367503747 no 1968 0.390665854369193 660 5394 DNA alkylating agent.
SGTC_125 0133-0007 11.75 µM -0.277963700666534 0.42262637246627 no 1969 0.390520111871587 683 26541
SGTC_1578 josamycin 24.2 µM -0.277975742950836 0.422621456843959 no 1970 0.390515489758255 704 5282165 A P450 substrate.
SGTC_2135 5326629 150.42 µM -0.278083293969141 0.4225775553934 no 1971 0.390474209821724 664 5020077
SGTC_3015 9080845 49.47 µM -0.278306842026174 0.422486307972896 no 1972 0.390388412170752 694 5296973
SGTC_339 3091-4833 71.4 µM -0.278308120269149 0.422485786234066 no 1973 0.390387921596976 662 3240077
SGTC_699 0375-0592 111 µM -0.278526012684224 0.422396851348887 no 1974 0.390304299745631 646 762578
SGTC_3333 9141820 12.094 µM -0.278671505695096 0.422337469179456 no 1975 0.390248465864051 680 1939433
SGTC_1412 3909-8563 178 µM -0.280646751319648 0.421531458782925 no 1976 0.389490677048533 678 23767530
SGTC_2458 5808907 16.39 µM -0.281970829631548 0.420991344757714 no 1977 0.388982938846487 698 2731747
SGTC_517 1365-0151 113 µM -0.28231050535765 0.42085280918294 no 1978 0.388852715477368 687 768657
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.282543271824237 0.420757881839377 no 1979 0.38876348571412 667 97141
SGTC_1545 lovastatin 49.4 µM -0.283639118369238 0.420311033235054 no 1980 0.388343477800767 650 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1296 1068-0102 11.9 µM -0.284010581409275 0.420159586633189 no 1981 0.388201135808323 692 767053
SGTC_425 3825-7017 13.1 µM -0.284310002110504 0.420037520513155 no 1982 0.388086410856582 699 3397440
SGTC_1911 st060208 74.3 µM -0.284996996332563 0.419757479723097 no 1983 0.387823221562352 674 688783
SGTC_965 1291-5240 308 µM -0.285261837860554 0.419649532699033 no 1984 0.38772177383023 701 2834598
SGTC_475 α-linolenic acid 10 µM -0.285367083737161 0.419606637104863 no 1985 0.38768146145134 689 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_360 0957-0399 1.01 µM -0.28551063725032 0.419548129813738 no 1986 0.387626478031949 702 6752301 YPR165W RHO1
SGTC_675 1309-0189 238 µM -0.28600453625326 0.419346847791945 no 1987 0.387437323595198 657 4246530
SGTC_3199 9111318 49.47 µM -0.289721122939223 0.417832882397191 no 1988 0.386014797652644 678 8548020
SGTC_1530 rhein 70.4 µM -0.290248256747632 0.417618250506108 no 1989 0.385813160397144 661 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_908 3448-7491 47.7 µM -0.290252389413291 0.417616567914763 no 1990 0.385811579707115 658 1203031
SGTC_2429 5902844 64.44 µM -0.29031695705189 0.417590279763404 no 1991 0.385786883684433 686 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_827 3253-0474 693 µM -0.290523577665674 0.417506158456769 no 1992 0.385707857928221 693 5402065
SGTC_724 3910-0327 137 µM -0.292277853573525 0.416792093800209 no 1993 0.385037095093793 714 2885483
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.293504317641608 0.416293033796134 no 1994 0.384568349872598 659 6708784 An antioxidant flavonoid
SGTC_2507 purpurin 79.67 µM -0.295032705121351 0.415671307167361 no 1995 0.383984448011119 653 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_62 0180-0423 3.232 µM -0.295185471881984 0.415609175363373 no 1996 0.383926099776877 696 30102 YGL099W LSG1
SGTC_1332 1480-0653 17.5 µM -0.295236661559575 0.415588356469788 no 1997 0.383906548813126 698 5749438
SGTC_543 3844-1095 191 µM -0.296398040192521 0.415116086385518 no 1998 0.383463060913272 692 4230703
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.297201716402353 0.414789346342377 no 1999 0.383156255773453 681 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1032 k061-1018 98.7 µM -0.297333126039972 0.41473592645883 no 2000 0.383106096823844 708 4005393
SGTC_2582 agaric acid 100 µM -0.297654192322034 0.414605415090676 no 2001 0.382983554335651 677 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2927 9011802 47.9 µM -0.298856280682745 0.414116857770241 no 2002 0.382524853170052 682 43912568
SGTC_952 1185-0122 232 µM -0.299413439228309 0.413890460295394 no 2003 0.382312304613397 678 678600
SGTC_1909 st060837 51.5 µM -0.300282965471744 0.413537191599015 no 2004 0.381980662809866 711 678937
SGTC_2842 9000675 19.48 µM -0.301600328347216 0.413002110489817 no 2005 0.381478378828703 650 2989072
SGTC_45 0kpi-0036 14.9 µM -0.302324056793324 0.412708218109848 no 2006 0.381202520588399 690 2795021
SGTC_821 1114-0266 29.2 µM -0.302495175471963 0.41263873720922 no 2007 0.38113730535905 685 3123235
SGTC_108 0509-0257 621.132 µM -0.30286453009128 0.412488774068377 no 2008 0.380996551719422 671 536624
SGTC_68 0986-0284 82.829 µM -0.302939293758225 0.412458420527868 no 2009 0.380968062700461 636 423278 YIL048W NEO1
SGTC_2878 9043973 25.97 µM -0.303049384629232 0.412413725335816 no 2010 0.380926113272091 671 6465167
SGTC_2663 amphotericin b 100 µM -0.30331697971085 0.412305090605382 no 2011 0.38082415369909 681 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_363 0455-0021 3.06 µM -0.303538202669026 0.412215286492141 no 2012 0.380739869166562 684 4597466
SGTC_1861 st057647 17.4 µM -0.304442681765144 0.411848166569705 no 2013 0.380395327326387 701 688668
SGTC_2412 st077135 33.4 µM -0.305140426418297 0.41156501098975 no 2014 0.380129601323897 726 13258915
SGTC_2735 sertaconazole 140 nM -0.305844422078758 0.411279365326179 no 2015 0.37986155204785 666 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1569 carminic acid 40.6 µM -0.306207966409562 0.411131875914308 no 2016 0.379723153618982 658 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1457 k015-0032 57.3 µM -0.307703393405616 0.410525315653105 no 2017 0.379154018684727 690 4302660
SGTC_2314 7727897 200 µM -0.308141824607771 0.410347524031004 no 2018 0.378987208558167 659 900724
SGTC_3103 9120822 49.47 µM -0.30875045945841 0.41010074236141 no 2019 0.378755678329822 712 17141819
SGTC_133 0724-0033 378.92 µM -0.309055307510754 0.409977149749524 no 2020 0.37863972770748 672 280309
SGTC_2677 mitomycin C 100 µM -0.313000692159477 0.40837840855275 no 2021 0.377140068143502 672 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1839 st053978 48 µM -0.3137948636661 0.408056779277412 no 2022 0.376838422850462 679 3788398
SGTC_103 0844-0104 51.839 µM -0.316556792696562 0.40693871706036 no 2023 0.375789962621928 691 5375804
SGTC_1198 1612-1005 86.7 µM -0.317434330097655 0.406583637568777 no 2024 0.375457030736191 680 6998509
SGTC_1461 k072-0203 53.8 µM -0.317570883118158 0.406528390778972 no 2025 0.375405231754982 692 5418714
SGTC_588 3970-1144 52.9 µM -0.318412788383445 0.406187812843306 no 2026 0.375085919483057 679 1888707
SGTC_730 1436-0052 41.2 µM -0.320399963349184 0.405384218133697 no 2027 0.374332576663028 655 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2709 st078560 56 µM -0.320795070512175 0.405224487951324 no 2028 0.374182847646497 711 17250903
SGTC_1492 4158-0558 28.5 µM -0.321265013197411 0.405034524527672 no 2029 0.374004783821109 689 3967268
SGTC_554 4483-2211 187 µM -0.32181639407801 0.404811670132573 no 2030 0.373795896898147 670 747107
SGTC_484 loperamide 105 µM -0.322376586003193 0.404585286147131 no 2031 0.37358370992619 660 3955 An opioid-receptor agonist.
SGTC_2671 danthron 100 µM -0.322628885863465 0.404483337503474 no 2032 0.373488157433428 685 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_830 4076-0286 57.8 µM -0.324114363232837 0.403883221545113 no 2033 0.372925726556469 677 6866659
SGTC_135 0933-0004 26.348 µM -0.324731706638211 0.403633888278264 no 2034 0.372692067800868 683 21230617 YGL099W LSG1
SGTC_1870 st057514 26.5 µM -0.326071251705888 0.403093006281554 no 2035 0.372185223593947 660 5393161
SGTC_2138 5575593 77.673 µM -0.326762898780504 0.402813805269882 no 2036 0.371923611404767 708 762213
SGTC_3104 9120930 49.47 µM -0.327233291168286 0.402623947666603 no 2037 0.371745721509049 715 17014836
SGTC_2120 5538279 151.968 µM -0.328503809939718 0.402111261638296 no 2038 0.371265382035238 687 2058197
SGTC_1363 1636-0063 10.4 µM -0.328895954876016 0.401953055333767 no 2039 0.371117165962257 691 6072185
SGTC_1395 3486-0190 4.35 µM -0.329789136134981 0.401592771765675 no 2040 0.370779648341411 720 6748079
SGTC_3058 9093861 49.47 µM -0.330025017491016 0.401497637974735 no 2041 0.370690529473332 722 17217477
SGTC_1128 3448-9350 235 µM -0.331818121493804 0.400774648799226 no 2042 0.370013299925445 671 619386
SGTC_2520 obtusaquinone 4.71 µM -0.335241717142592 0.39939518217941 no 2043 0.368721377595662 662 5967872
SGTC_531 3788-1495 174 µM -0.335312857423258 0.399366530936176 no 2044 0.36869454788853 666 2896655
SGTC_2302 7771753 200 µM -0.336143023985016 0.399032227349536 no 2045 0.368381507827235 675 2203047
SGTC_985 1493-0307 8.71 µM -0.336754008143867 0.398786234618343 no 2046 0.368151173077771 704 3278274
SGTC_706 4262-0057 46.9 µM -0.337211039093105 0.398602252373841 no 2047 0.367978908082791 685 883298
SGTC_212 3807-4682 38.772 µM -0.337224338058772 0.398596899083312 no 2048 0.367973895808086 686 3125501 YBL034C STU1
SGTC_942 3253-1115 227 µM -0.337879229535816 0.398333306389389 no 2049 0.367727100227355 726 46497897
SGTC_1755 st041960 45.185 µM -0.340807991816946 0.397155053762556 no 2050 0.366624066837543 733 2257073
SGTC_2456 5770359 74.46 µM -0.341786448946309 0.396761625098927 no 2051 0.36625580414995 733 3118787
SGTC_1204 4049-0315 18.3 µM -0.342195812042138 0.39659705509274 no 2052 0.366101768353322 690 588402
SGTC_2989 9073649 71.4286 µM -0.344161102297933 0.395807236358663 no 2053 0.365362566650186 734 21367202
SGTC_2409 alverine citrate 63.97 µM -0.345270242799008 0.395361679078615 no 2054 0.364945607754607 666 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3295 9122362 53.5725 µM -0.345594058699231 0.395231623458875 no 2055 0.364823905816802 718 4730473
SGTC_811 0416-0114 265 µM -0.34702723303832 0.394656151582178 no 2056 0.36428542980978 725 6612453
SGTC_355 1311-2252 105 µM -0.34845061446345 0.394084839345316 no 2057 0.363750898226467 693 5338538
SGTC_323 4013-0906 34.3 µM -0.348886543916867 0.39390991290655 no 2058 0.363587243808512 705 2910086
SGTC_817 1391-0715 46 µM -0.349946072819994 0.39348484253876 no 2059 0.363189584669075 726 1353946
SGTC_357 1325-0123 420 µM -0.351152746669628 0.393000893973202 no 2060 0.362736879108222 731 1098503
SGTC_2568 diosmetin 100 µM -0.351207115488744 0.39297909270369 no 2061 0.36271648617141 736 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.352128646669084 0.392609620443703 no 2062 0.362370892785229 701 688803
SGTC_1341 1486-1360 280 µM -0.352199880062212 0.392581064650285 no 2063 0.362344183444467 714 3976547
SGTC_2706 st078239 82.5 µM -0.352946788486261 0.392281681462064 no 2064 0.36206416651761 703 15434492
SGTC_41 0478-0632 82.643 µM -0.353257043427948 0.392157340750773 no 2065 0.361947873230918 726 3750424
SGTC_2264 7948757 110.76 µM -0.354205317805698 0.391777369631333 no 2066 0.361592509290599 678 2971411
SGTC_2370 9071495 200 µM -0.354778638217741 0.391547691646512 no 2067 0.36137771647453 733 21791103
SGTC_769 0302-0231 76 µM -0.355818595702153 0.391131170631354 no 2068 0.360988210974973 717 571869 YER009W NTF2
SGTC_1656 st012921 11 µM -0.356742865819826 0.390761089171139 no 2069 0.360642155940968 715 6732821
SGTC_222 nsc-310342 10.666 µM -0.35749757376946 0.390458974430598 no 2070 0.360359671104441 727 432556
SGTC_3296 9122258 64.045 µM -0.35750618767985 0.390455526604854 no 2071 0.36035644738418 704 4730474
SGTC_2177 5811945 192 µM -0.35761083511715 0.390413640842786 no 2072 0.360317284307474 705 5343475
SGTC_1462 k081-0014 26.5 µM -0.357722352471686 0.39036900675516 no 2073 0.360275551857833 721 3270634
SGTC_1418 3966-3099 2.4 µM -0.358749832287748 0.389957832774745 no 2074 0.35989112283267 707 740335
SGTC_1978 st071761 42 µM -0.359009882638396 0.38985378606011 no 2075 0.359793848091614 686 5147680
SGTC_2926 9010726 65.15 µM -0.359521166493032 0.389649243289099 no 2076 0.359602623134059 736 2994293
SGTC_1470 k295-0292 231 µM -0.36108495066175 0.389023830130771 no 2077 0.359017971517163 691 5045612
SGTC_3259 9138485 49.47 µM -0.363080053889903 0.388226334540218 no 2078 0.358272542045078 692 17646153
SGTC_829 1635-0120 117 µM -0.363496557585777 0.388059906307075 no 2079 0.358116991986615 709 285054
SGTC_46 0329-0187a 2.197 µM -0.364387310558793 0.387704044656509 no 2080 0.357784404908605 729 46494817
SGTC_523 1934-0222 13.7 µM -0.364484944860491 0.387665044842733 no 2081 0.35774795702097 730 1361595
SGTC_2031 5180455 200 µM -0.364587092485852 0.387624243404579 no 2082 0.357709825651602 690 29949
SGTC_848 0368-0089 85.6 µM -0.365166968972221 0.387392643395557 no 2083 0.357493386607307 725 762535
SGTC_3258 9138477 49.47 µM -0.365346358305253 0.387321004230467 no 2084 0.357426438771962 696 4970355
SGTC_550 4123-0385 25.7 µM -0.365614978629635 0.38721373782703 no 2085 0.357326198266435 730 5731123
SGTC_3242 9133940 49.47 µM -0.365657798313174 0.387196639717441 no 2086 0.357310220240886 733 17248444
SGTC_1745 st081495 74 µM -0.367327716284936 0.386530004285792 no 2087 0.356687291157709 699 13842402 YBL026W LSM2
SGTC_1122 capsaicin 818.572 nM -0.367369627596004 0.386513277483439 no 2088 0.356671661899439 734 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2053 5265679 138 µM -0.367694007999457 0.386383824412888 no 2089 0.356550704482652 685 764595
SGTC_639 0833-0042 114 µM -0.369469705645303 0.385675407038303 no 2090 0.355888824843605 725 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_385 1494-0393 12.4 µM -0.369485753803114 0.385669006334963 no 2091 0.355882844974761 716 3090647
SGTC_1555 citronellol 128 µM -0.37010001894232 0.385424034097481 no 2092 0.355653984000118 717 8842 A terpine precursor.
SGTC_1825 st052143 62.6 µM -0.370803204525435 0.385143656021651 no 2093 0.355392057194978 728 674173
SGTC_1449 4112-4002 201 µM -0.371479190466719 0.384874179730571 no 2094 0.355140326250863 689 2059539
SGTC_3154 9100113 49.47 µM -0.371981000296135 0.384674173277981 no 2095 0.354953497757561 716 25237525
SGTC_945 3381-0768 11.3 µM -0.372908011453906 0.38430477498943 no 2096 0.354608454572633 723 1126236 YIL048W NEO1
SGTC_1356 1502-0781 85.8 µM -0.372948657747443 0.384288580529657 no 2097 0.354593328327139 704 567702
SGTC_2938 9059746 27.26 µM -0.374270544081096 0.383762019510259 no 2098 0.354101522305728 730 6471769
SGTC_101 0490-5701 117.494 µM -0.374602520295558 0.383629813569487 no 2099 0.353978049192256 722 4661669
SGTC_680 0417-1641 114 µM -0.376929025924842 0.382703688749009 no 2100 0.353113175041483 703 2835990
SGTC_1434 4073-0095 163 µM -0.377202242456198 0.382594971831145 no 2101 0.353011656967255 721 24133745
SGTC_2317 5986382 200 µM -0.377240479251256 0.382579757579982 no 2102 0.352997450294556 718 877883
SGTC_1657 st012939 43.4 µM -0.377551236776365 0.382456115262409 no 2103 0.35288199763262 709 24207257
SGTC_3218 9131285 49.47 µM -0.378213952765897 0.382192477884896 no 2104 0.352635830587657 746 17156417
SGTC_342 k048-0088 23.3 µM -0.37839588897148 0.382120110751982 no 2105 0.352568260846562 675 6820570
SGTC_2567 aureobasidin a 60 nM -0.378568750138973 0.382051357130523 no 2106 0.352504065815822 683 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2222 6885208 172.143 µM -0.379569227908161 0.381653501264481 no 2107 0.352132603390486 691 609514
SGTC_3238 9133470 49.47 µM -0.379896761332769 0.381523279536749 no 2108 0.352011025759231 706 3534688
SGTC_3026 9090633 49.47 µM -0.380480016601891 0.38129142035561 no 2109 0.351794563806497 703 25236842
SGTC_3281 9140613 49.47 µM -0.380553936702494 0.381262038227769 no 2110 0.351767133467318 683 16013766
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.38177260061977 0.38077773642651 no 2111 0.351315021853283 734 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2993 9054257 71.4286 µM -0.383249869108453 0.380190914600251 no 2112 0.350767252663045 730 6470217 YGL055W OLE1
SGTC_408 cantharidin 100 µM -0.384347541125351 0.379755059979411 no 2113 0.350360438056763 693 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2218 6965428 192.983 µM -0.385134021121795 0.379442864815777 no 2114 0.35006906162853 702 675684
SGTC_2558 carylophyllene oxide 100 µM -0.385379935579566 0.379345264587466 no 2115 0.349977972930285 736 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3288 9119690 36.221 µM -0.387943390675448 0.378328321747077 no 2116 0.349028963355967 738 17595618 YKL019W RAM2
SGTC_2552 juarezic acid 87.02 µM -0.390866607812139 0.377169686501953 no 2117 0.347947918744025 707 1549512
SGTC_2719 novobiocin 32.65 µM -0.391102961331791 0.377076054461728 no 2118 0.347860565902816 727 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_877 0771-0151 33.1 µM -0.391524354193543 0.376909136554555 no 2119 0.347704845231619 721 6166523
SGTC_3310 9130229 44.1445 µM -0.391724049299582 0.376830043366817 no 2120 0.347631059273711 731 7761258
SGTC_22 0964-0034 14.468 µM -0.392335214660438 0.376588011394916 no 2121 0.34740527378135 733 138402
SGTC_594 1487-1584 10.8 µM -0.392529755113067 0.376510980209619 no 2122 0.347333415205581 747 5013332
SGTC_926 2268-1401 59.4 µM -0.393265053203297 0.376219872437282 no 2123 0.347061863315559 733 2931578
SGTC_2862 9027634 71.43 µM -0.393530854876345 0.376114657693839 no 2124 0.346963719792351 703 5012562
SGTC_511 blebbistatin 171 µM -0.393650093076798 0.376067461521309 no 2125 0.346919696101715 724 3476986 A myosin inhibitor.
SGTC_11 0438-0307 1.3 µM -0.394005369054333 0.375926849236949 no 2126 0.346788537641726 722 4011476
SGTC_1464 k208-0027 110 µM -0.396471903293405 0.374951091381276 no 2127 0.345878465597951 743 X1464
SGTC_2296 7971656 126.45 µM -0.396562401771694 0.374915305471294 no 2128 0.345845091450346 713 666570
SGTC_1358 1509-0022 2.48 µM -0.397301035116599 0.374623267188466 no 2129 0.345572742077634 720 3258434
SGTC_515 4092-1064 102 µM -0.397836473360378 0.374411612417493 no 2130 0.345375364889559 769 717353
SGTC_1864 st057645 30.4 µM -0.398142970743608 0.374290473298116 no 2131 0.34526240048425 740 688666
SGTC_2816 7982706 58.44 µM -0.398153984604361 0.374286120443278 no 2132 0.345258341410084 725 2981853
SGTC_503 tyrphostin 8 294 µM -0.398350083471178 0.374208621701672 no 2133 0.345186073652339 757 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1559 coumarin 343 70.1 µM -0.399243401660128 0.37385564457812 no 2134 0.344856933106707 743 108770 A hepatotoxic, DNA x-linker.
SGTC_1410 3909-8106 77.9 µM -0.399271218134858 0.373844655141304 no 2135 0.34484668608879 726 1039210
SGTC_1408 3909-7976 48.8 µM -0.400113717695692 0.373511858009846 no 2136 0.344536380510477 705 24152374
SGTC_1693 xanthone 101.9 µM -0.402473692378429 0.372580143348242 no 2137 0.343667722830516 739 7020 An insecticide.
SGTC_1174 0739-0097 51.1 µM -0.402763672261058 0.372465710995727 no 2138 0.343561044066589 711 728447
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.402966228484576 0.372385784593465 no 2139 0.343486534399522 699 23665772 A membrane-active detergent.
SGTC_2627 acetyl isogambogic acid 100 µM -0.403076021411574 0.372342463838986 no 2140 0.343446149959506 733 6857789 A caspase activator and apoptosis inducer.
SGTC_227 fluconazole 33.516 µM -0.404350540156788 0.371839698113552 no 2141 0.342977482659434 730 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3014 9081533 49.47 µM -0.404586472638322 0.371746652598192 no 2142 0.342890751800567 754 21367265
SGTC_1711 st032263 62.8 µM -0.405049853073208 0.371563929450131 no 2143 0.34272043317052 724 3958979
SGTC_1067 clotrimazole 1.36 µM -0.405068988472137 0.371556384478622 no 2144 0.342713400511548 723 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_401 neomycin 50 µM -0.406955951131157 0.370812609352401 no 2145 0.342020170371345 712 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1654 st012436 41.8 µM -0.407199273288703 0.370716735270796 no 2146 0.341930817650732 739 4323132
SGTC_269 exalamide 29 µM -0.407259673146466 0.370692937691432 no 2147 0.341908638996732 699 3316 A derivative of salicylamide.
SGTC_869 0564-0080 44.1 µM -0.407394515103225 0.370639811666523 no 2148 0.341859127386742 713 6843321
SGTC_2181 6316240 54.2555 µM -0.407583332553923 0.37056542412516 no 2149 0.341789801489566 706 12779990
SGTC_2930 9013230 14.89 µM -0.410174134446914 0.369545227642779 no 2150 0.340839106730643 718 2995857
SGTC_852 0418-0143 439 µM -0.411378715848235 0.369071204100597 no 2151 0.340397429140615 731 5369229
SGTC_1714 st033236 13.627 µM -0.412331384215315 0.368696453598504 no 2152 0.340048274123397 738 2916566
SGTC_3306 9127676 59.7925 µM -0.412656919561829 0.368568426579616 no 2153 0.339928996135968 700 41905287
SGTC_1821 st053465 65.6 µM -0.413070986595764 0.368405602768652 no 2154 0.339777302790738 732 675086
SGTC_1588 farnesol 29.9 µM -0.413230302629818 0.368342961128688 no 2155 0.339718944315097 705 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2821 7996764 71.43 µM -0.413292581502584 0.368318474584111 no 2156 0.339696132212649 674 2987135
SGTC_2658 polymyxin b sulfate 77.05 µM -0.414210395434762 0.367957674443177 no 2157 0.339360014655104 721 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1061 3448-9325 110 µM -0.414787889121067 0.367730716636721 no 2158 0.33914859306543 754 723482
SGTC_2762 leflunomide 42.06 µM -0.416084081408532 0.367221475060861 no 2159 0.338674238952812 723 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_520 3584-0023 682 µM -0.416247634927655 0.367157235538464 no 2160 0.338614403117991 710 1340790
SGTC_2643 anethole 100 µM -0.417002073637135 0.36686096001273 no 2161 0.338338445483915 748 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1429 4049-0205 9.46 µM -0.417115811386214 0.366816300949945 no 2162 0.338296850160743 722 22774478
SGTC_2991 9074669 71.4286 µM -0.418004882188815 0.366467269963272 no 2163 0.337971773838213 763 17333109
SGTC_1348 1493-0373 93.8 µM -0.419263647075411 0.365973293533944 no 2164 0.337511730656192 745 3010129
SGTC_3031 9088762 49.47 µM -0.419858140852896 0.36574007382089 no 2165 0.33729454424293 731 205253
SGTC_2040 5100729 123 µM -0.420001441181031 0.365683864567161 no 2166 0.337242200438774 726 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_524 r073-0010 27.8 µM -0.421790346851869 0.364982413122093 no 2167 0.336589026126021 748 2772106
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.423062630586064 0.36448381000908 no 2168 0.336124783125714 719 688664
SGTC_2351 9026858 72.31 µM -0.423512009885193 0.364307754715724 no 2169 0.335960868998278 749 1409300
SGTC_1044 1222-0021 1.78 µM -0.423581590142209 0.364280497512515 no 2170 0.335935491918791 754 4306703
SGTC_218 alverine citrate 93.75 µM -0.423806918008756 0.36419223282505 no 2171 0.335853316223486 738 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1045 1348-1485 165 µM -0.42452111441021 0.363912517785096 no 2172 0.335592905031439 730 6810614
SGTC_69 0096-0274 206.684 µM -0.424711953922771 0.363837787753102 no 2173 0.335523334248665 756 6741392
SGTC_3234 9132280 49.47 µM -0.424958138419516 0.363741393064317 no 2174 0.335433595711635 722 17612295
SGTC_634 1611-4317 11.2 µM -0.425080074007629 0.363693651808808 no 2175 0.335389151542069 736 2843522
SGTC_563 tetrahydrosecaminediol 614 µM -0.426273303608822 0.363226580225338 no 2176 0.334954354237016 732 334274 A psychoactive constituent of the cannabis plant.
SGTC_1774 st048371 48.465 µM -0.426615251238462 0.363092767474389 no 2177 0.334829793717595 722 4242727
SGTC_2062 5245942 200 µM -0.427343416347084 0.36280787375944 no 2178 0.334564607153688 719 1376160
SGTC_166 k072-0058 166.424 µM -0.428111328425849 0.362507511341407 no 2179 0.334285034740561 757 5846229
SGTC_2585 alliin 100 µM -0.429586124866541 0.361930894398025 no 2180 0.333748366001663 769 87310 A garlic compound which reacts with lipids.
SGTC_315 k915-0449 187 µM -0.430117853763488 0.361723075428049 no 2181 0.333554956665041 729 20970215 YNL149C PGA2
SGTC_569 4130-2812 160 µM -0.432207558380122 0.360906738484127 no 2182 0.332795283205592 760 743552
SGTC_2436 5633522 8.09 µM -0.433210413940406 0.360515200547176 no 2183 0.332430956987701 746 5724242
SGTC_3291 9121177 71.43 µM -0.434172749791709 0.360139619887887 no 2184 0.332081499908132 732 17015612
SGTC_3240 9133527 49.47 µM -0.43444531995923 0.360033265649846 no 2185 0.331982546870341 766 17617455
SGTC_2075 5212009 200 µM -0.434477175035259 0.360020836814771 no 2186 0.331970983065805 758 780898
SGTC_312 4092-0653 6.84 µM -0.434650570064756 0.359953186197722 no 2187 0.331908041234635 738 1148278
SGTC_1163 k060-0048 49.9 µM -0.434681881356179 0.359940970466239 no 2188 0.331896675843372 708 6809982
SGTC_2190 6049624 200 µM -0.437040480378224 0.35902120288088 no 2189 0.33104099549503 757 2265554
SGTC_2404 5161160 200 µM -0.43803428374829 0.358633900043247 no 2190 0.330680715561139 741 2831543
SGTC_997 3996-0078 137 µM -0.439163356408895 0.358194056722885 no 2191 0.330271587227149 735 735687
SGTC_583 1488-1091 88.9 µM -0.439213003622321 0.358174720390138 no 2192 0.330253601822025 753 4303273
SGTC_1250 0485-0349 40.2 µM -0.439233772654714 0.358166631485728 no 2193 0.330246078062691 748 6842794 YDL195W SEC31
SGTC_2271 7849410 118.62 µM -0.439380515613487 0.358109481394834 no 2194 0.330192921128593 767 972430
SGTC_709 3807-1509 243 µM -0.441347209937301 0.357343845571975 no 2195 0.329480826665746 769 1886677 YPL242C IQG1
SGTC_374 0880-0231 82.3 µM -0.44166766940574 0.357219144716704 no 2196 0.329364854193057 734 6833587
SGTC_1003 4049-0218 100 µM -0.441797928606642 0.35716846112389 no 2197 0.329317718814703 739 295161
SGTC_1995 st072814 61.1 µM -0.442230033488244 0.357000348035005 no 2198 0.329161377486076 714 5769371
SGTC_1252 0493-0875 34.8 µM -0.442242706116178 0.35699541808926 no 2199 0.329156792810479 715 3960963
SGTC_676 falcarinol 140 µM -0.443298210804705 0.356584886214946 no 2200 0.328775024884907 776 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2943 9068529 45.32 µM -0.443691992759569 0.356431769729803 no 2201 0.328632642704862 737 3270634
SGTC_1982 st072467 71.9 µM -0.44380700032221 0.356387055047582 no 2202 0.328591063400724 749 3163533
SGTC_2645 abamectin 100 µM -0.445111167410926 0.35588013607541 no 2203 0.328119709430401 741 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_231 b-estradiol 524 µM -0.445586992631607 0.355695250112626 no 2204 0.327947804058672 709 450 A steroid.
SGTC_2133 5320837 200 µM -0.44693325962764 0.355172330545813 no 2205 0.32746162440695 744 2841355
SGTC_1431 4049-0260 9.09 µM -0.448280993470368 0.354649114265394 no 2206 0.32697520795094 752 3854841
SGTC_2874 9043904 71.43 µM -0.45096793919566 0.3536068088872 no 2207 0.326006328153797 740 4463428
SGTC_1670 st016595 4.04 µM -0.453905925660008 0.352468376283629 no 2208 0.324948269190813 753 597879
SGTC_1168 k815-0004 80.5 µM -0.454929351732149 0.352072121160802 no 2209 0.324580032869687 725 642433
SGTC_3353 9151644 39.2805 µM -0.455226599382264 0.351957061431712 no 2210 0.324473113059918 740 4909158
SGTC_3038 9091290 49.47 µM -0.455732152564363 0.351761401156072 no 2211 0.324291299099779 763 25236843
SGTC_2589 lobaric acid 100 µM -0.456526380437586 0.351454096677247 no 2212 0.324005752594591 735 73157 A novel microtubule depolymerizer.
SGTC_3316 9136639 10.545 µM -0.458016044090007 0.350877974483491 no 2213 0.32347045729862 749 4903665
SGTC_2848 9016370 25.97 µM -0.458137403619409 0.350831054189561 no 2214 0.32342686407219 726 7894410
SGTC_2796 7949634 45.45 µM -0.458588165895586 0.350656799386624 no 2215 0.323264968204649 720 2971588
SGTC_2675 theaflavin digallate 100 µM -0.45974354542048 0.350210298557126 no 2216 0.322850154737116 748 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_184 1494-0393 24.714 µM -0.460044370322836 0.350094077558545 no 2217 0.322742186334784 747 3090647
SGTC_2780 5215298 71.43 µM -0.460558741085456 0.349895387565826 no 2218 0.322557609277583 768 2834131
SGTC_384 k007-0144 5.16 µM -0.461937808975157 0.349362887211263 no 2219 0.322062959730324 728 6824886
SGTC_3331 9141060 1.957 µM -0.464151456653779 0.348508750020171 no 2220 0.32126961875747 729 4906567 YPR165W RHO1
SGTC_777 1315-0167 517 µM -0.465156653001336 0.348121147564706 no 2221 0.320909638960421 721 4221767
SGTC_2922 7999257 32.47 µM -0.465508326125101 0.347985580277632 no 2222 0.320783737893128 754 2988377
SGTC_3112 9123419 49.47 µM -0.466906984764134 0.347446600550877 no 2223 0.320283213890279 771 17015854
SGTC_2665 lovastatin 100 µM -0.468127583673756 0.346976488847211 no 2224 0.319846677325639 753 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_215 1287-0124 461.5 µM -0.470641172821747 0.346009126322391 no 2225 0.318948500136225 751 5560863
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.470913306721109 0.345904454883719 no 2226 0.318851322550835 771 688751
SGTC_1913 st060213 96.1 µM -0.472249190323001 0.345390802048418 no 2227 0.318374466245912 761 688959
SGTC_774 k060-0086 136 µM -0.472265891345947 0.345384382234605 no 2228 0.318368506559608 777 5911235
SGTC_1616 st002734 56.1 µM -0.472278004986758 0.345379725821999 no 2229 0.318364183889777 727 4026101
SGTC_2134 5324836 1.464 µM -0.473112782952183 0.345058898466221 no 2230 0.318066358684087 768 699272
SGTC_2875 9039966 71.43 µM -0.473726611822035 0.344823058741923 no 2231 0.317847436897888 750 6463691
SGTC_2971 9092186 9.93 µM -0.473860311998898 0.344771697672726 no 2232 0.317799761230463 706 25236400
SGTC_691 1548-0686 185 µM -0.474056564881152 0.344696312094996 no 2233 0.317729785588603 763 46495133
SGTC_2981 9013952 38.96 µM -0.474400883452712 0.344564065731601 no 2234 0.317607031591328 720 2996344
SGTC_1673 st016611 27.3 µM -0.474908309299081 0.344369207523862 no 2235 0.317426164302713 780 5226799
SGTC_182 3448-4371 550.524 µM -0.475396878444163 0.344181629563893 no 2236 0.317252059493 707 3491403
SGTC_266 formosanin C 406 nM -0.476041938449866 0.343934028269506 no 2237 0.317022250081406 745 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2215 7188065 200 µM -0.477128417175004 0.343517143115542 no 2238 0.3166353401497 746 940217
SGTC_2721 ifenprodil 61.44 µM -0.477273621569627 0.343461442155934 no 2239 0.316583646061459 730 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_880 0833-0487 87.2 µM -0.477586244675406 0.343341530279736 no 2240 0.316472361546113 738 76075
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.47877151866012 0.342887041721203 no 2241 0.31605059028248 746 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2066 5222451 176 µM -0.479421228785868 0.342638009361685 no 2242 0.315819497083343 758 2281147
SGTC_970 1315-0089 19.5 µM -0.479497530659217 0.342608767518156 no 2243 0.315792362248837 742 6811083 YLR033W RSC58
SGTC_815 1582-0027 36.9 µM -0.480612068488499 0.342181740892233 no 2244 0.315396118235513 739 3128206
SGTC_2083 5306046 65.942 µM -0.481797364069005 0.341727825327797 no 2245 0.314974951041689 760 539837
SGTC_1691 st019933 84.6 µM -0.484151998904236 0.340826783835716 no 2246 0.314139000079857 762 6176082
SGTC_2522 biochanin a 4.94 µM -0.485050142268464 0.340483332600337 no 2247 0.313820388721974 763 5280373 A possible chelator.
SGTC_2381 9035592 200 µM -0.485098214568143 0.340464953414151 no 2248 0.313803339252141 755 4749657
SGTC_3304 9125678 46.087 µM -0.48618534681807 0.340049418077772 no 2249 0.313417879800224 761 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.486425961167076 0.339957474116346 no 2250 0.31333259380055 756 5024745
SGTC_2774 tamoxifen 10.92 µM -0.486624357147286 0.339881669868823 no 2251 0.3132622796523 755 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_481 bay k-8644 50 µM -0.487299493886746 0.339623758357329 no 2252 0.313023053166822 784 2303 A calcium channel antagonist.
SGTC_3121 9125696 49.47 µM -0.487840681116072 0.339417071604322 no 2253 0.312831346876776 774 1235365
SGTC_1842 st055362 61.2 µM -0.487852190172809 0.339412676663496 no 2254 0.312827270540301 717 676032
SGTC_1100 amiodarone 5.07 µM -0.489330743342189 0.338848246308517 no 2255 0.312303779514691 737 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2059 5238311 157 µM -0.491461084421479 0.338035635265884 no 2256 0.311550184864673 733 703021
SGTC_2697 mebhydrolin 72.4 µM -0.491469577276428 0.338032397203227 no 2257 0.311547182147519 742 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3156 9099931 49.47 µM -0.491730660457461 0.337932860116916 no 2258 0.311454880205274 746 18111053
SGTC_2178 5812956 200 µM -0.494202321071141 0.336991110044177 no 2259 0.310581650353657 751 5403383
SGTC_3063 1327-0034 4 µM -0.494696020464656 0.336803123243765 no 2260 0.310407355524682 757 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3041 9091929 49.47 µM -0.494815472636485 0.336757645349806 no 2261 0.310365190718453 758 25236887
SGTC_2601 securinine 100 µM -0.49613177075178 0.336256661834936 no 2262 0.309900722574264 774 442872 A GABA receptor antagonist.
SGTC_2247 cerulenin 830 nM -0.497116520635411 0.335882055682017 no 2263 0.309553442581904 727 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1445 4239-0156 97.7 µM -0.498503166403913 0.33535484175187 no 2264 0.309064718988958 779 4008346
SGTC_1679 SEC14.276 6.7 µM -0.498822438511852 0.335233497778915 no 2265 0.308952239272138 739 1005053 YMR079W SEC14
SGTC_2019 4016004 108 µM -0.499089406951895 0.335132045766311 no 2266 0.308858199913131 758 45595336
SGTC_2712 st079126 47.7 µM -0.499342630675808 0.335035828065082 no 2267 0.308769013694295 750 3152970
SGTC_171 k064-0041 9.68 µM -0.500760224669856 0.334497383373223 no 2268 0.308269940866804 741 53325
SGTC_85 0868-0259 160.055 µM -0.501059887425312 0.334383606003736 no 2269 0.308164488039779 759 83173
SGTC_3217 9129673 49.47 µM -0.503522656455195 0.333449107287019 no 2270 0.307298427654842 772 17248312
SGTC_451 chloral hydrate 100 µM -0.504356063816646 0.333133104083509 no 2271 0.307005593460905 789 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2164 5685496 200 µM -0.505716624376504 0.332617474688835 no 2272 0.306527798052449 761 759046
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.505991676620607 0.332513272978758 no 2273 0.306431246381833 761 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_931 2812-0076 566 µM -0.507839272990987 0.331813659169954 no 2274 0.30578303261706 778 3450959
SGTC_1790 st045711 43.5 µM -0.508673528506479 0.331497950556614 no 2275 0.305490540156709 733 585119
SGTC_2399 5884133 200 µM -0.508856378310661 0.331428770403389 no 2276 0.305426449047621 765 722445
SGTC_864 0469-0573 172 µM -0.509037360522264 0.331360302506131 no 2277 0.305363018424723 778 689425
SGTC_786 4544-0069 423 µM -0.51007602835769 0.33096747016343 no 2278 0.30499909929762 735 748821 YLR208W SEC13
SGTC_976 1348-1067 47.6 µM -0.510389608151926 0.330848908358331 no 2279 0.30488926788758 754 5310671 YGL099W LSG1
SGTC_2885 9057732 51.95 µM -0.511485255228475 0.330434786940827 no 2280 0.304505655242965 773 6471414
SGTC_289 k017-0060 526 µM -0.511546175229305 0.330411767111828 no 2281 0.304484331975519 768 5512909
SGTC_2769 toremifene 3.73 µM -0.512325682555952 0.330117271491473 no 2282 0.304211546866688 747 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1650 st011916 45.8 µM -0.513243448095128 0.329770677198526 no 2283 0.303890518531849 785 242528
SGTC_1750 st081859 2.357 µM -0.514633133646928 0.329246140451466 no 2284 0.303404703527 769 5291695
SGTC_126 0417-1624 672.48 µM -0.51616264323117 0.328669215453941 no 2285 0.302870409482074 788 41912 YDL195W SEC31
SGTC_3098 9119039 49.47 µM -0.516404088844607 0.328578180381072 no 2286 0.302786105301739 774 17161528
SGTC_469 w7 172 µM -0.516649386499864 0.328485703345829 no 2287 0.302700466889626 758 45115570 A P450 inhibitor.
SGTC_1023 4482-3888 16 µM -0.516964595709453 0.328366885130105 no 2288 0.302590436862047 764 3303168
SGTC_2144 5628481 200 µM -0.517733306134091 0.328077192282727 no 2289 0.302322178429102 764 2818399
SGTC_2729 fluphenazine 10.66 µM -0.51800857182742 0.327973481987824 no 2290 0.302226144351975 778 3372 An atypical antipsychotic.
SGTC_1784 st039334 36.3 µM -0.518711045513243 0.327708875087251 no 2291 0.301981128980635 787 3496984
SGTC_483 fpl-64176 144 µM -0.519344683110587 0.32747027146731 no 2292 0.301760199475225 776 3423
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.519511802852861 0.327407352319262 no 2293 0.301701942187765 780 140250 A respiratory chain inhibitor.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.520954007387498 0.3268645785605 no 2294 0.3011994056172 788 1273210
SGTC_3212 9128307 49.47 µM -0.522536357857816 0.32626948207906 no 2295 0.300648469406114 749 27243542
SGTC_2969 9091408 28.7 µM -0.523213338620503 0.326015015458646 no 2296 0.300412900078139 750 4286311
SGTC_644 1498-1197 63.3 µM -0.5244680084013 0.325543618702781 no 2297 0.299976532661294 768 6741615
SGTC_3092 9117248 49.47 µM -0.524942719088946 0.325365336026157 no 2298 0.299811505654104 772 17141857
SGTC_198 3454-2873 16.191 µM -0.525424382657362 0.325184482958667 no 2299 0.299644103595039 776 710957
SGTC_1293 1000-1278 195 µM -0.525576164122176 0.325127501204073 no 2300 0.299591360759063 789 678847
SGTC_1880 MG-132 525 µM -0.5266861673574 0.324710908484914 no 2301 0.299205771527151 763 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_340 k038-0059 454 µM -0.527606070380267 0.324365827882416 no 2302 0.298886389430682 757 23733424
SGTC_1268 0828-0275 2.46 µM -0.528602085394469 0.323992365609905 no 2303 0.298540756675412 771 745337
SGTC_1142 3253-1408 9.78 µM -0.528853710221621 0.323898045257871 no 2304 0.298453467709075 775 256655
SGTC_1663 st014140 55.4 µM -0.529196528319988 0.323769559744287 no 2305 0.29833456237603 752 4207120
SGTC_2724 maprotiline 69.64 µM -0.529510845502145 0.323651774601666 no 2306 0.298225561446364 768 4011 A tricyclic antidepressant.
SGTC_1631 benzylvanillin 81.9 µM -0.530765768319336 0.323181689257493 no 2307 0.297790552126071 763 75506
SGTC_1087 pterostilbene 9.05 µM -0.532493133938405 0.322535091800052 no 2308 0.297192247995439 782 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1413 3910-0535 34.4 µM -0.532584988516016 0.322500723268032 no 2309 0.297160447903244 764 2876951
SGTC_1 0258-0098 57.368 µM -0.533339363720015 0.322218521811061 no 2310 0.296899341768418 748 6790032 YDR047W HEM12
SGTC_325 2810-4341 181 µM -0.53505246887288 0.321578053254738 no 2311 0.296306787996866 754 774970
SGTC_612 0302-0167 22.4 µM -0.538356382920141 0.320344336183336 no 2312 0.295165516301229 776 235821
SGTC_259 usnic acid 108.925 µM -0.540037264329316 0.319717437095437 no 2313 0.294585666933423 817 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1125 tnp00248 1.32998 µM -0.540090087218907 0.319697744679717 no 2314 0.294567453276528 758 24207736
SGTC_1345 1488-0192 31.4 µM -0.540254060986433 0.319636618365329 no 2315 0.29451091742416 787 658348
SGTC_1587 estradiol valerate 56.1 µM -0.541064769868493 0.319334473468862 no 2316 0.294231469998462 784 13791 A steroid.
SGTC_3009 9080819 71.4286 µM -0.542229666919879 0.318900535403207 no 2317 0.293830150218235 785 17027216
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.542639038076385 0.318748098647428 no 2318 0.293689177530707 800 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1387 3342-1166 1.8 µM -0.542723825122292 0.318716530489304 no 2319 0.293659983838399 757 3418228
SGTC_2853 9015042 58.44 µM -0.543649132823292 0.318372102808007 no 2320 0.293341471250046 756 6457456
SGTC_31 0508-1974 57.237 µM -0.543837388498433 0.318302047520679 no 2321 0.293276688840295 754 6810525
SGTC_721 1187-1332 279 µM -0.544088164453987 0.318208736753284 no 2322 0.293190402297823 784 25730
SGTC_759 3486-0358 89.3 µM -0.544905853798151 0.31790456436925 no 2323 0.292909135004125 809 875103
SGTC_1343 1487-0095 224 µM -0.545028304067081 0.317859024643354 no 2324 0.292867025566489 799 4560101 YGL055W OLE1
SGTC_429 1112-0049 25.5 µM -0.545837938224711 0.317557987934331 no 2325 0.292588671119381 750 2836170
SGTC_2912 7964298 10.93 µM -0.546006647994314 0.317495273749932 no 2326 0.292530683716811 773 2975850
SGTC_584 0986-0246 15.4 µM -0.54643393934718 0.317336460926372 no 2327 0.292383842879236 803 53315 YDR232W HEM1
SGTC_1396 3511-0007 98.6 µM -0.548060739630642 0.316732130455799 no 2328 0.291825098597113 774 X1396
SGTC_2818 7996756 12.99 µM -0.548261346093755 0.316657642161469 no 2329 0.291756232341781 787 2241621
SGTC_3081 9117243 49.47 µM -0.548380924177594 0.316613244498572 no 2330 0.291715185946794 790 45595589
SGTC_2071 5230951 39.92 µM -0.548987364399364 0.316388122448406 no 2331 0.291507060611472 785 1799272
SGTC_851 0394-0702 453 µM -0.549223683882863 0.316300414612157 no 2332 0.291425976448844 791 762646
SGTC_1735 st034310 56.75 µM -0.55020712157153 0.315935531641676 no 2333 0.291088659764321 773 871153
SGTC_688 0527-0193 473 µM -0.551967002256023 0.315283014119546 no 2334 0.290485480647846 788 4007154
SGTC_3341 9147222 25.867 µM -0.552860804627542 0.314951836017075 no 2335 0.290179364201522 793 1939759
SGTC_1121 fusaric acid 630.51 nM -0.553959001307775 0.314545127902379 no 2336 0.289803452265404 753 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2942 9052777 62.25 µM -0.554069262458581 0.314504306009517 no 2337 0.289765722576539 811 6469503
SGTC_1065 prochlorperazine maleate 2.48 µM -0.555241532225093 0.314070437865935 no 2338 0.289364732274687 809 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_752 1896-0090 130 µM -0.555729609019614 0.313889871719211 no 2339 0.289197856093127 773 772567
SGTC_1996 st072960 66.8 µM -0.555775862261924 0.313872762440501 no 2340 0.28918204419851 742 1719405
SGTC_2596 sinensetin 100 µM -0.556699276858231 0.313531271086659 no 2341 0.28886645554303 763 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2127 5253358 187.912 µM -0.560290074992535 0.312204865362477 no 2342 0.287640798030488 778 20612
SGTC_868 0527-0199 213 µM -0.562798498990587 0.311279718721979 no 2343 0.286786051268835 786 2849450
SGTC_2338 7999974 200 µM -0.562802219119386 0.31127834756226 no 2344 0.286784784527613 803 315925
SGTC_1915 st067105 30.6 µM -0.566125224469577 0.310054606685417 no 2345 0.285654328510707 793 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_79 0052-0007 94.094 µM -0.566399323541709 0.309953759678416 no 2346 0.285561177252773 789 2801472
SGTC_3158 9100007 49.47 µM -0.567046033956654 0.309715877529131 no 2347 0.28534145313029 771 19297233
SGTC_2990 9074105 71.4286 µM -0.567063849430928 0.309709325517228 no 2348 0.285335401345505 803 6502001
SGTC_294 k038-0071 157 µM -0.567071405705128 0.309706546558194 no 2349 0.285332834553537 779 24152826
SGTC_1066 ketoconazole 628 nM -0.567111638086469 0.309691750541949 no 2350 0.285319168194791 803 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2151 5563267 85.4165 µM -0.567859729693168 0.309416685673638 no 2351 0.285065109101782 803 5310824
SGTC_570 0987-0065 62.6 µM -0.56790116876346 0.309401452112633 no 2352 0.285051039148833 774 3104428
SGTC_1815 st051655 58.2 µM -0.569918559396627 0.308660228651162 no 2353 0.28436646817603 791 5984156
SGTC_1305 1181-0477 144 µM -0.572750596512532 0.30762100482561 no 2354 0.28340678692194 783 6252086
SGTC_157 1348-1695 65.819 µM -0.575647024772659 0.306559747020215 no 2355 0.282426894572746 759 5380510
SGTC_1534 6-azauridine 81.6 µM -0.576211666307501 0.306353049514463 no 2356 0.282236060326498 783 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3123 9126162 49.47 µM -0.576884877582675 0.306106688557118 no 2357 0.282008613447993 766 25239884
SGTC_1632 st005650 90 µM -0.577002301189695 0.306063726487916 no 2358 0.281968950498775 781 2759605
SGTC_1419 3993-2473 62.6 µM -0.577241254444231 0.305976308299956 no 2359 0.281888245974461 792 704026
SGTC_521 r062-0005 13.8 µM -0.577463777351901 0.305894910894352 no 2360 0.281813100675883 778 2832033
SGTC_3006 9075424 71.4286 µM -0.577681089034912 0.305815428972243 no 2361 0.281739724510693 798 7465181
SGTC_1024 4507-0395 26 µM -0.579075711347575 0.305305562552148 no 2362 0.281269044001252 757 4201836
SGTC_729 4092-0585 94.1 µM -0.579497771372843 0.305151334041184 no 2363 0.281126674978081 778 2169061
SGTC_1300 1094-0077 113 µM -0.580799931132442 0.304675718970228 no 2364 0.280687650753169 791 5532636
SGTC_693 4161-2696 114 µM -0.583800280153055 0.303581095657944 no 2365 0.279677344875198 807 805759
SGTC_2198 6589944 200 µM -0.585779179187384 0.302860092442858 no 2366 0.279011958577207 772 5290268
SGTC_168 3970-0862 530.542 µM -0.585896069322467 0.302817528022493 no 2367 0.2789726794571 805 3135186
SGTC_884 0851-0618 334 µM -0.585966529136618 0.302791872051758 no 2368 0.278949003826884 804 9642473
SGTC_2057 5236571 38.335 µM -0.586335257308279 0.302657625879998 no 2369 0.27882512117786 781 54684039 YBR257W POP4
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.58737831541467 0.302278014864899 no 2370 0.278474827053288 811 442882
SGTC_34 0469-0683 81.75 µM -0.587511194361599 0.302229670188958 no 2371 0.278430217218905 779 3690923
SGTC_2452 5863136 48.41 µM -0.590446556810651 0.30116259834688 no 2372 0.277445652738986 797 2184096
SGTC_2319 6033012 152.6 µM -0.591251012078259 0.300870456937483 no 2373 0.27717612382601 794 847246
SGTC_2043 5101342 149 µM -0.593486354729874 0.300059354439323 no 2374 0.276427856119689 802 678451
SGTC_2301 7769476 200 µM -0.594327330564384 0.299754459470564 no 2375 0.276146601127272 798 977820
SGTC_2188 6126565 140.678 µM -0.594414363650348 0.299722913723133 no 2376 0.27611750190466 790 874518
SGTC_1941 st076221 61.8 µM -0.595823376237571 0.299212416675285 no 2377 0.275646612797985 781 2828568
SGTC_2537 larixol 68.93 µM -0.596410200161772 0.298999921900706 no 2378 0.275450613973631 793 6708759
SGTC_320 4092-0846 5.34 µM -0.59678789953643 0.298863189463808 no 2379 0.275324498893576 796 1359356
SGTC_2403 6032726 181.2 µM -0.598008736055468 0.298421424078378 no 2380 0.274917051990126 777 2881040
SGTC_2287 7945887 168.79 µM -0.598403576413022 0.298278612876499 no 2381 0.274785339994829 788 1245853
SGTC_1759 st043059 70 µM -0.600582185406545 0.297491184255328 no 2382 0.274059153139108 817 669426
SGTC_796 1234-0020 70.7 µM -0.600933982641936 0.297364120986086 no 2383 0.273941978987952 782 46495034
SGTC_1202 1988-0068 29.6 µM -0.601656650820531 0.297103183148049 no 2384 0.273701355459384 785 2850480
SGTC_2058 5236698 133 µM -0.605265463229055 0.295801698802119 no 2385 0.27250131263445 774 766665
SGTC_557 1315-0110 16.2 µM -0.605795904170624 0.295610621235925 no 2386 0.272325144934711 789 6833801
SGTC_1627 st003713 25.6 µM -0.607235358127546 0.29509238147954 no 2387 0.27184736514714 789 16195070 YER133W GLC7
SGTC_2335 9018011 154.17 µM -0.607740342395261 0.294910673591571 no 2388 0.271679850969262 780 6458208
SGTC_1831 st055328 12 µM -0.607897476455208 0.294854142750373 no 2389 0.27162773669555 802 1103068
SGTC_606 k015-0008 38.6 µM -0.610450437268404 0.293936385473866 no 2390 0.270781732846794 821 1970475
SGTC_479 n-linoleoylglycine 10 µM -0.611985405311464 0.293385220449251 no 2391 0.27027370687462 816 6433346 An anti-infammatory.
SGTC_1964 st076914 61 µM -0.612712990496586 0.293124131910435 no 2392 0.270033065737039 821 24208661
SGTC_1990 st072050 59.8 µM -0.612761427421794 0.29310675450575 no 2393 0.270017049540988 795 17233948
SGTC_2121 5257820 149.641 µM -0.614014737272964 0.292657278798619 no 2394 0.269602794358003 783 791256
SGTC_1427 4048-4900 550 nM -0.61405882490433 0.292641473440497 no 2395 0.269588227919386 814 24132586
SGTC_714 4296-0578 26.1 µM -0.614722962537548 0.292403428961293 no 2396 0.269368846297906 800 1589775
SGTC_3181 9108277 49.47 µM -0.615002060334973 0.292303419807746 no 2397 0.269276679886789 820 17097298
SGTC_642 0335-0876 158 µM -0.615516131262216 0.292119254348496 no 2398 0.269106959749517 808 6812350
SGTC_2605 digitonin 300 nM -0.616012984444222 0.291941308466724 no 2399 0.268942975064557 813 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2491 paeonol 100 µM -0.616844811035751 0.291643506316367 no 2400 0.268668545906488 813 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3079 9117512 49.47 µM -0.616862481176509 0.291637181767474 no 2401 0.268662717850421 849 7185044
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.617614135995146 0.291368206485242 no 2402 0.268414862059645 810 4620898
SGTC_2528 xanthyletin 44.79 µM -0.619689150088813 0.290626276322149 no 2403 0.267731230133505 818 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2283 7944793 200 µM -0.619988002485866 0.290519493222836 no 2404 0.267632842872894 797 2970533
SGTC_1187 1391-0724 117 µM -0.620982166474177 0.29016440019403 no 2405 0.267305678490621 803 6997986
SGTC_1336 1486-0901 104 µM -0.621047726566001 0.290140990752335 no 2406 0.267284110747181 798 5006114
SGTC_421 streptovitacin 30 mM -0.621056057117651 0.290138016238374 no 2407 0.26728137025257 810 91467 include heat shock
SGTC_1884 5633444 25 µM -0.621415802526893 0.290009578867052 no 2408 0.267163038634213 803 5724239
SGTC_3007 9078383 71.4286 µM -0.621465521177514 0.289991830263869 no 2409 0.267146686681121 792 6496995
SGTC_3267 9137951 49.47 µM -0.621792503062585 0.289875116702107 no 2410 0.2670391582894 823 16643986
SGTC_689 0833-0039 98 µM -0.623577221190823 0.289238464519837 no 2411 0.266452637017201 852 5374726
SGTC_559 1550-0661 158 µM -0.623881202572407 0.289130092541494 no 2412 0.266352803012444 799 5830875
SGTC_2371 9071574 200 µM -0.624111364196623 0.289048050645551 no 2413 0.266277225592489 808 45596039
SGTC_1793 st048256 72.231 µM -0.624343078800353 0.288965466247466 no 2414 0.266201149191503 805 672022
SGTC_124 0136-0217 7.121 µM -0.625571594936867 0.288527801700593 no 2415 0.265797987412136 809 3976905
SGTC_1486 3970-0793 4.53 µM -0.630331362089085 0.286835068951071 no 2416 0.264238903964835 816 2844330
SGTC_2224 6650123 117.647 µM -0.630661450599891 0.286717853139894 no 2417 0.264130954906052 808 2908370
SGTC_162 k030-0015 37.8 µM -0.630717155443554 0.286698074356717 no 2418 0.26411273993081 827 1809920 YMR134W ERG29
SGTC_1561 5-methoxyflavone 52.9 µM -0.630816625748688 0.286662757643935 no 2419 0.264080215640961 800 94525
SGTC_143 4032-1194 15.74 µM -0.631420072203957 0.28644854954163 no 2420 0.263882947566969 807 1806963
SGTC_3290 9121031 71.43 µM -0.633802760689749 0.285603498811319 no 2421 0.263104775653833 805 17014854
SGTC_2214 7179297 48.276 µM -0.634506416908314 0.285354165309414 no 2422 0.262875190191701 797 769744
SGTC_2122 5258151 111.688 µM -0.637410512589553 0.284326226635184 no 2423 0.261928741276801 810 2173356
SGTC_2100 5377183 190 µM -0.638757382276176 0.283850087817774 no 2424 0.261490388379174 790 2844202
SGTC_600 1495-0418 41.6 µM -0.638786722288017 0.283839719928873 no 2425 0.261480843557487 817 5377768
SGTC_1154 4088-0362 150 µM -0.639460138259383 0.283601804567973 no 2426 0.261261818684204 810 6618304
SGTC_567 1080-0542 68.4 µM -0.639553626814421 0.283568782962839 no 2427 0.261231419494215 781 5950415
SGTC_225 nsc-122657 1.016 µM -0.641135817212453 0.283010208422657 no 2428 0.260717222619129 817 275685
SGTC_3057 9095946 49.47 µM -0.641489999880418 0.282885240600714 no 2429 0.260602187998543 825 24540043
SGTC_2803 7707263 71.43 µM -0.642666383296348 0.282470362373229 no 2430 0.260220299246901 806 2199229
SGTC_414 piperonyl butoxide 100 µM -0.642961129753454 0.282366459225476 no 2431 0.260124661056523 810 5794 A potent inhibitor of cytochrome P450.
SGTC_1862 st057513 3.81 µM -0.645069285583962 0.281623834904915 no 2432 0.25944114346388 825 5393163
SGTC_1575 cyproterone acetate 48 µM -0.646070165641704 0.281271592387363 no 2433 0.25911695784263 825 9880 An androgen receptor antagonist and liver toxin.
SGTC_859 0439-0102 54.6 µM -0.646621261017348 0.281077734694302 no 2434 0.258938547184976 821 610143
SGTC_1352 1496-0991 99 µM -0.647410024608209 0.280800385294657 no 2435 0.258683304837703 825 3000039
SGTC_48 0382-0018 55 µM -0.649072516092689 0.280216244643391 no 2436 0.258145752741683 796 762596
SGTC_1389 3405-0187 19 µM -0.65073929612285 0.279631188766331 no 2437 0.257607395975225 805 799890
SGTC_3299 9121982 43.1275 µM -0.650815172594406 0.279604569508622 no 2438 0.257582902356927 820 17594604 YPL160W CDC60
SGTC_2974 9094440 9.66 µM -0.652619824789365 0.278971817715203 no 2439 0.257000700801987 804 25236134
SGTC_273 hydroxyurea 18.1 mM -0.654670236482368 0.278253743423716 no 2440 0.256340046089956 843 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1901 st060216 58.6 µM -0.655660048303355 0.277907424419355 no 2441 0.256021439969793 813 688792
SGTC_1212 0520-0165 585 µM -0.659652264196842 0.276512752570864 no 2442 0.254738503306216 856 5403258
SGTC_2435 5706476 10.6 µM -0.661235589090658 0.275960573436465 no 2443 0.25423062056533 796 5725375
SGTC_2029 5175081 200 µM -0.661478794515312 0.275875804385262 no 2444 0.254152654688612 810 1380876
SGTC_2734 clemastine 41.6 µM -0.662598684924915 0.27548563265864 no 2445 0.253793806329251 848 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1620 st003704 16.5 µM -0.664158472087836 0.274942652863191 no 2446 0.253294444721703 822 2834414
SGTC_2937 9044753 11.33 µM -0.665267546789503 0.274556892294929 no 2447 0.252939691963775 811 6465530 YGL099W LSG1
SGTC_1574 spiramycin 23.7 µM -0.666963241158375 0.273967609208395 no 2448 0.252397806783664 834 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1668 st014914 51.6 µM -0.669444750221648 0.273106370297298 no 2449 0.251605906735366 825 2839556
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.669599302053154 0.273052775560466 no 2450 0.251556629554379 840 279621
SGTC_139 0099-0334 718.624 µM -0.670359997389508 0.272789061312444 no 2451 0.251314164396976 839 97690
SGTC_13 0199-0087 65 µM -0.670412989295216 0.272770695038825 no 2452 0.251297278283085 818 4589825
SGTC_2364 9055074 200 µM -0.671735675205811 0.272312468954758 no 2453 0.250875992772602 829 6470630
SGTC_1513 0337-0559 19 µM -0.672283596698375 0.272122761288865 no 2454 0.250701585188131 822 775073
SGTC_1439 4092-1168 46 µM -0.672475697481035 0.272056265510515 no 2455 0.250640453252052 837 2886240
SGTC_1167 k781-0610 148 µM -0.673272238417822 0.271780628718154 no 2456 0.250387055527589 813 4525169
SGTC_2332 7982454 138.89 µM -0.675296433805623 0.27108079759272 no 2457 0.249743724601141 849 2981748
SGTC_2850 9015429 58.44 µM -0.675491058460144 0.271013556820955 no 2458 0.249681915169718 847 6457570
SGTC_1789 tunicamycin 25 nM -0.675580667603946 0.270982600601489 no 2459 0.249653459583836 840 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1898 st060199 18.6 µM -0.675730411349782 0.270930874323979 no 2460 0.249605911963874 816 688866
SGTC_2284 7945075 39.21 µM -0.676102664344174 0.270802307588638 no 2461 0.249487732589016 831 1245402
SGTC_2038 4100038 30.985 µM -0.676791520470765 0.270564474517656 no 2462 0.249269119476928 814 3596803
SGTC_1181 1222-0449 220 µM -0.676868139767116 0.270538027544333 no 2463 0.249244810125401 830 658318
SGTC_698 k064-0052 127 µM -0.678153043637404 0.270094704923094 no 2464 0.248837330751966 859 5088751
SGTC_1229 0139-0193 12.2 µM -0.678294977980252 0.270045756473048 no 2465 0.248792341116589 829 3090752
SGTC_1074 carmofur 3.8 µM -0.678602073784205 0.269939864502627 no 2466 0.24869501425436 832 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1232 0279-0259 161 µM -0.678754257373212 0.26988739665865 no 2467 0.248646790725408 827 1560000
SGTC_2775 cyproheptadine 69.59 µM -0.679446025757541 0.269648962272379 no 2468 0.248427647798817 829 2913 A selective serotonin reuptake inhibitor.
SGTC_1098 clofazimine 15.1 µM -0.6814921080357 0.268944349678272 no 2469 0.247780079377819 840 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1954 st077032 68.9 µM -0.68197224185462 0.268779139241186 no 2470 0.247628251584949 850 698907
SGTC_1554 st069299 38.7 µM -0.682836924313269 0.268481737134321 no 2471 0.247354947296998 801 24207999
SGTC_25 0118-0223 35.662 µM -0.683384375766247 0.268293530210712 no 2472 0.247181995112271 834 5333628
SGTC_3138 9097216 49.47 µM -0.683607571233136 0.268216817466077 no 2473 0.247111501224099 833 25237486
SGTC_3329 9141233 27.5565 µM -0.684338939536951 0.267965522022917 no 2474 0.246880581781503 833 4909101 YNL103W MET4
SGTC_1952 st077036 64.1 µM -0.685042187503913 0.267724000480481 no 2475 0.246658649914715 833 2937007
SGTC_2978 9011784 42.97 µM -0.685407972306349 0.267598419738326 no 2476 0.246543257346963 812 2994934
SGTC_2992 9074591 71.4286 µM -0.685422552747172 0.267593414616656 no 2477 0.246538658317079 837 17741321
SGTC_1727 st034309 9.9045 µM -0.685429569416059 0.267591005976432 no 2478 0.246536445103401 850 870305
SGTC_3326 9140064 16.379 µM -0.685844907983684 0.267448450505484 no 2479 0.246405457031525 846 1868434
SGTC_2036 5160441 105 µM -0.686403558452181 0.267256766924911 no 2480 0.246229330577501 829 134534 YIL048W NEO1
SGTC_1609 st001574 46.4 µM -0.689071427668468 0.266342327468824 no 2481 0.245389159724762 844 3960012
SGTC_855 0428-0020 25 µM -0.689394978477176 0.266231534869387 no 2482 0.245287371297007 820 6812414
SGTC_2778 tioconazole 65.09 nM -0.690168054080411 0.265966907250276 no 2483 0.245044255215146 837 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1474 0330-0125 5.35 µM -0.69177560105051 0.265417062912115 no 2484 0.244539130655152 834 X1474
SGTC_755 1995-0008 37.3 µM -0.692972894725227 0.265007916478873 no 2485 0.24416328092717 808 689533
SGTC_2666 tannic acid 100 µM -0.693754197504487 0.264741097860793 no 2486 0.243918185482131 836 16134267 A thiamine antagonist.
SGTC_812 4251-0442 148 µM -0.694281025537877 0.264561260719981 no 2487 0.243752993979784 846 5723007
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.694423316995884 0.264512699007032 no 2488 0.24370838761876 833 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_128 0906-2981 13.371 µM -0.695637852818099 0.264098382751712 no 2489 0.243327827211799 848 6740226
SGTC_875 0709-0210 25.7 µM -0.698153160759862 0.263241384986246 no 2490 0.242540707636804 841 6251364
SGTC_3318 9139014 38.6185 µM -0.698354864570365 0.263172723474328 no 2491 0.242477647900683 855 16643984
SGTC_2108 5365811 200 µM -0.69888324024144 0.262992903760728 no 2492 0.242312501113188 824 780283
SGTC_1158 4092-0494 91.8 µM -0.700188282668719 0.262549033827694 no 2493 0.241904864093688 819 1148199
SGTC_1837 st055472 66.5 µM -0.702040388020864 0.261919756188436 no 2494 0.241326988252649 828 676091
SGTC_678 1218-2179 85.9 µM -0.702456833901558 0.261778369688741 no 2495 0.241197156237695 859 6820081 YOR116C RPO31
SGTC_3170 9103054 49.47 µM -0.703084529064329 0.2615653364788 no 2496 0.2410015364763 841 16432970
SGTC_1822 st052468 42 µM -0.703607105637531 0.261388047333515 no 2497 0.240838742522129 838 2873678
SGTC_307 1501-1223 22.3 µM -0.705230839012835 0.260837574183516 no 2498 0.240333296275061 836 2830329
SGTC_1497 4476-2978 41.3 µM -0.70638176703066 0.260447751543782 no 2499 0.239975378229078 827 1528379
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.706677249849214 0.260347719085936 no 2500 0.23988353526712 827 6708739 YPR165W RHO1
SGTC_2639 lactacystin 53 µM -0.710041220722052 0.259210280695927 no 2501 0.238839287368196 830 3870 A proteasome inhibitor.
SGTC_3182 9108849 49.47 µM -0.710291316019688 0.259125820235082 no 2502 0.238761751903791 822 17133045
SGTC_3338 9144300 39.5675 µM -0.710424314041238 0.259080910855293 no 2503 0.238720524976978 825 4901274
SGTC_2166 5933061 31.504 µM -0.711767061527996 0.258627731466374 no 2504 0.238304516329132 849 2877375
SGTC_1483 3453-0561 55.9 µM -0.713249849901179 0.258127765339617 no 2505 0.237845582102781 858 4546991
SGTC_1171 0368-0077 21.4 µM -0.713676146465489 0.257984119600357 no 2506 0.237713729849471 847 3239779
SGTC_2949 9072542 2.23 µM -0.714937691358969 0.257559269970251 no 2507 0.237323772800606 862 16457352
SGTC_2691 st077356 60.2 µM -0.715437737034352 0.257390970538839 no 2508 0.237169300596192 862 2839272
SGTC_2696 st077691 74.316 µM -0.715563618622199 0.257348611815015 no 2509 0.237130422440499 853 757133
SGTC_1078 idebenone 36.1 µM -0.71790566848068 0.256561181243135 no 2510 0.23640772625959 853 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2635 hydroquinidine 100 µM -0.719380903308479 0.256065831219824 no 2511 0.235953129947864 834 442912 An experimental heart treatment.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.720641209506959 0.255643044770474 no 2512 0.235565146197075 843 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_474 dl-dihydrosphingosine 5 µM -0.720696687120428 0.255624442448716 no 2513 0.235548075571587 818 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1093 fluphenazine 7.97 µM -0.721039921647368 0.255509367436424 no 2514 0.235442476468913 849 6602611 An atypical antipsychotic.
SGTC_316 k060-0003 58.6 µM -0.721656919962778 0.255302576690039 no 2515 0.23525271725359 857 6152314
SGTC_2359 9039622 200 µM -0.722731374975277 0.254942675483481 no 2516 0.234922467863246 855 6463596
SGTC_2683 piperine 63.03 µM -0.723827319161511 0.254575849921324 no 2517 0.234585877558712 852 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_604 1000-0114 314 µM -0.725221440210161 0.254109620874573 no 2518 0.23415809583979 855 1572745
SGTC_582 0987-0078 156 µM -0.727197171424834 0.253449654708577 no 2519 0.233552589365085 864 1625765
SGTC_2349 9023730 187.07 µM -0.727884977969724 0.253220113829049 no 2520 0.233341999797156 859 4126287
SGTC_597 k018-0003 82.8 µM -0.729964076288646 0.252526923975807 no 2521 0.232706071715718 853 6786234
SGTC_1208 2323-2347 50.3 µM -0.731165168959034 0.252126925117 no 2522 0.232339136215098 836 5412760
SGTC_3143 9086658 49.47 µM -0.731294866803263 0.252083751957122 no 2523 0.232299532605447 855 25236626
SGTC_1780 st038448 24.544 µM -0.731545786065482 0.25200023829953 no 2524 0.232222924350219 854 728868 YDL195W SEC31
SGTC_2661 dactinomycin 12.96 µM -0.73194941295335 0.251865929477961 no 2525 0.232099722373558 839 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2417 cerulenin 830 nM -0.732951740177469 0.251532563686297 no 2526 0.231793932149935 845 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1558 st069300 45.6 µM -0.735101603608495 0.250818323819831 no 2527 0.231138808891268 836 24208000
SGTC_1729 st035615 45.989 µM -0.736908295158361 0.250218925816916 no 2528 0.230589059599933 855 17385451
SGTC_1422 4031-0024 15.5 µM -0.737748889307815 0.249940304796898 no 2529 0.230333528611056 873 782427
SGTC_2251 lansoprazole 556 µM -0.738401010129089 0.249724268096421 no 2530 0.230135400470382 852 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_20 0481-0013 4.944 µM -0.739563710513254 0.249339331092392 no 2531 0.229782384085173 846 182045
SGTC_722 3534-0461 190 µM -0.741253233213762 0.248780540905096 no 2532 0.229269955988114 846 658262
SGTC_659 k018-0002 107 µM -0.741675195003154 0.248641086030563 no 2533 0.229142076076053 866 6797879 YHR007C ERG11
SGTC_2168 5727979 200 µM -0.744556546660266 0.247689937127427 no 2534 0.22826992252281 853 695210
SGTC_1277 0873-0036 22 µM -0.745585658298599 0.247350693662842 no 2535 0.227958874537058 854 5965735
SGTC_635 k038-0028 24.7 µM -0.746325915882156 0.247106823711417 no 2536 0.227735279923794 872 4035102
SGTC_944 3370-0224 231 µM -0.746452921644213 0.247064995949632 no 2537 0.227696930276137 850 4580514
SGTC_1617 st002906 78 µM -0.746507460065721 0.247047035564062 no 2538 0.227680463404811 862 5150859
SGTC_2024 5144227 134 µM -0.746709449138124 0.246980523375338 no 2539 0.227619482366241 838 3475211
SGTC_3109 9122853 49.47 µM -0.748631981504717 0.246347940139865 no 2540 0.227039525236527 891 1234709
SGTC_2929 9013348 24.6 µM -0.748878327652197 0.246266946093309 no 2541 0.226965271954774 861 2995952
SGTC_788 1182-0090 188 µM -0.752341127637285 0.245129953992265 no 2542 0.225922970429534 850 5715185
SGTC_2832 7992762 51.95 µM -0.754980169549038 0.244265337779869 no 2543 0.225130440419272 854 2985177
SGTC_192 3455-0609 60.9 µM -0.755385334810108 0.244132741218812 no 2544 0.225008904967402 841 3769639
SGTC_2146 5545642 200 µM -0.755433546329334 0.244116965842453 no 2545 0.224994445668418 850 825326
SGTC_576 1073-0113 22.7 µM -0.755922282835003 0.243957076544886 no 2546 0.224847896585655 878 5439563
SGTC_1728 st035614 33.7865 µM -0.757296573553996 0.243507782694387 no 2547 0.224436101625473 865 15945546
SGTC_1385 3091-4834 14.1 µM -0.757307332431414 0.243504267082364 no 2548 0.224432879505361 846 4072814
SGTC_914 3820-6779 408 µM -0.760960536641389 0.242312118785722 no 2549 0.223340319343938 851 2893481
SGTC_780 0109-0199 192 µM -0.761498307633694 0.242136895704467 no 2550 0.2231797446608 848 610414
SGTC_1038 k292-0204 154 µM -0.761997395284628 0.241974338382952 no 2551 0.223030779374442 860 4454212
SGTC_1417 3966-0327 90.4 µM -0.762352150473643 0.241858827439512 no 2552 0.222924928187011 880 651118
SGTC_3050 9093513 49.47 µM -0.762592285986487 0.241780654503614 no 2553 0.222853293248366 864 25236664
SGTC_2258 7960471 200 µM -0.763530385491743 0.24147540009051 no 2554 0.222573574067012 860 2974708
SGTC_963 1269-2853 151 µM -0.763956685574765 0.241336752686777 no 2555 0.222446527601702 840 3668223
SGTC_2549 cedrol 20.94 µM -0.764483376611944 0.241165514451418 no 2556 0.222289619633538 852 6708665 A sedative which affects the nervous system.
SGTC_354 2783-3500 4.88 µM -0.764606234317859 0.241125580352207 no 2557 0.222253027843112 856 6740761
SGTC_377 3970-0964 33.1 µM -0.764783493695547 0.241067969678642 no 2558 0.222200239181824 847 16481235
SGTC_1722 st034304 3.6505 µM -0.76516782195658 0.240943085719851 no 2559 0.222085809028804 880 4036148 YLR033W RSC58
SGTC_2017 5132927 60.65 µM -0.765449399693938 0.240851611944694 no 2560 0.222001993240527 850 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2701 st077767 14.721 µM -0.766629858354207 0.240468332051107 no 2561 0.221650808846979 850 5721188
SGTC_1105 epirubicin 18.1 µM -0.76672793744846 0.24043650197085 no 2562 0.221621644777982 854 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1684 st024538 14.6195 µM -0.766884716698463 0.240385626412839 no 2563 0.221575030622545 855 6732859
SGTC_3226 9131256 49.47 µM -0.767823450212191 0.240081125954916 no 2564 0.221296040341017 826 17178073
SGTC_1781 st038725 66.3 µM -0.771491416305459 0.238893352770845 no 2565 0.220207854148714 879 4270275 YIL048W NEO1
SGTC_3243 9134147 49.47 µM -0.77153022172638 0.238880803871151 no 2566 0.220196358059075 863 24282180
SGTC_807 1315-0151 48 µM -0.771642401385118 0.238844529232896 no 2567 0.220163126817974 882 4011080
SGTC_2356 9061756 188.97 µM -0.773483385384394 0.238249655616671 no 2568 0.219618178921322 852 20104043
SGTC_2228 7354201 200 µM -0.774484460920596 0.237926520992882 no 2569 0.219322176945134 881 753451
SGTC_1097 itavastatin 7.23 µM -0.778745637153229 0.236553758787178 no 2570 0.21806478343897 858 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2556 citropten 84.59 µM -0.780548889033376 0.23597414599667 no 2571 0.2175339313661 830 2775 A potential DNA crosslinker.
SGTC_2786 7743617 45.45 µM -0.78273152704323 0.235273636703472 no 2572 0.216892392221489 857 583674
SGTC_364 0083-0097 67.7 µM -0.783022645035325 0.235180290357886 no 2573 0.216806907141675 883 5207356
SGTC_1276 0871-0068 94.2 µM -0.783366598628013 0.235070028755169 no 2574 0.216705932309404 861 3414906
SGTC_3348 9149464 3.537 µM -0.785924594864599 0.234250905469734 no 2575 0.215955832320135 860 1951442
SGTC_881 0833-0569 170 µM -0.788165640156446 0.233534576883781 no 2576 0.21529991216762 865 5418700
SGTC_929 2805-0021 398 µM -0.790101553307232 0.232916760114263 no 2577 0.214734231403646 913 3098024
SGTC_3082 9117008 49.47 µM -0.790176936483582 0.23289272111713 no 2578 0.214712221652736 871 41448529
SGTC_1295 1013-0063 9.78 µM -0.790406964632866 0.232819375789865 no 2579 0.214645068056821 873 6826038
SGTC_2026 5148700 152 µM -0.790718610710929 0.232720026759718 no 2580 0.214554106689321 872 79838
SGTC_204 PMA1.184 62.41 µM -0.791060877915313 0.232610943234785 no 2581 0.214454233637022 859 2252213 YGL008C PMA1
SGTC_1808 st050063 61.5 µM -0.792678310080673 0.232095838320735 no 2582 0.213982635231936 874 4011993
SGTC_1320 1313-0481 95.3 µM -0.795740136409044 0.231122476999514 no 2583 0.213091546478393 869 6813365 YLR208W SEC13
SGTC_2817 7995342 71.43 µM -0.796386637189132 0.23091724464506 no 2584 0.212903671373317 883 18879975
SGTC_2440 5628896 157.78 µM -0.796887800571148 0.230758219838135 no 2585 0.212758098298428 885 5522048
SGTC_656 4090-1979 187 µM -0.796998952283382 0.230722958433043 no 2586 0.212725819902846 858 22330961
SGTC_2513 baicalein 25.65 µM -0.797560465602931 0.230544871804303 no 2587 0.212562800457527 887 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_605 1315-0399 119 µM -0.79782113292183 0.230462226036131 no 2588 0.212487147910049 880 24020461
SGTC_3325 9138760 55.175 µM -0.802345636074848 0.229030352868162 no 2589 0.211176525404457 855 43844959
SGTC_109 0132-0036 33.701 µM -0.802582389326862 0.228955565042324 no 2590 0.211108075258218 835 67274 A color developer.
SGTC_1436 4092-1007 8.32 µM -0.803215732606402 0.228755566036353 no 2591 0.21092502685969 841 2881121
SGTC_611 3453-1652 23.7 µM -0.803852480444224 0.228554590840592 no 2592 0.210741088325434 880 1560575
SGTC_1910 st062352 60.4 µM -0.807374218554718 0.227444826035057 no 2593 0.209725457928834 878 2245730
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.80739351613061 0.227438753385168 no 2594 0.209719900660955 894 75037 A free radical scavenger.
SGTC_3146 9095609 49.47 µM -0.807992254181941 0.227250385124145 no 2595 0.209547520589673 879 17173999
SGTC_3120 9124077 49.47 µM -0.809308141991593 0.226836704338044 no 2596 0.209168962048326 895 18774327 YGL155W CDC43
SGTC_2106 5357045 167.29 µM -0.809318452155639 0.226833464769732 no 2597 0.209165997580089 868 668842
SGTC_1914 st062367 72.6 µM -0.809978501362079 0.226626124290248 no 2598 0.208976265965259 887 978205
SGTC_1139 k015-0024 46.9 µM -0.810395314198337 0.226495246489203 no 2599 0.208856505055253 885 2766652
SGTC_2318 6029776 164 µM -0.810431644903296 0.226483840794759 no 2600 0.208846068237603 877 818325
SGTC_438 sphingosine 6.67 µM -0.813097986906002 0.225647652739581 no 2601 0.208080940281134 872 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2256 7954252 200 µM -0.813551647024374 0.225505555068044 no 2602 0.207950923813742 908 2972920
SGTC_1640 st009078 66.4 µM -0.815009678406588 0.225049206387437 no 2603 0.207533385055288 870 690618
SGTC_2858 9025781 8.96 µM -0.81508493439391 0.225025666255804 no 2604 0.207511847333984 856 4894980 YPL153C RAD53
SGTC_2448 5185112 27.17 µM -0.815967255631267 0.224749779586434 no 2605 0.207259431905859 864 5718189
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.816576981378601 0.224559240964411 no 2606 0.207085107034104 868 6857784
SGTC_1777 st045864 34.765 µM -0.819724644094725 0.223577058881592 no 2607 0.206186548890816 906 4691462
SGTC_77 0828-0286 12.516 µM -0.819751633277306 0.223568647880027 no 2608 0.206178854340713 886 745345
SGTC_394 menadione 8.33 µM -0.820387994494371 0.223370382237481 no 2609 0.205997478641743 882 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_866 0495-0101 262 µM -0.821121330037381 0.223142027260313 no 2610 0.20578858072092 858 635694
SGTC_2095 5432005 200 µM -0.822167633157824 0.222816446835138 no 2611 0.205490748587342 891 783734
SGTC_1337 1486-1011 40.3 µM -0.822809837323421 0.222616744894092 no 2612 0.20530807080119 870 X1337
SGTC_2543 pimpinellin 60.67 µM -0.82357459646518 0.222379066006835 no 2613 0.205090657602837 876 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_44 0929-0055 61.211 µM -0.82365625413995 0.222353696238601 no 2614 0.205067451249469 875 1379590
SGTC_1816 st051957 91.6 µM -0.824314026246653 0.222149396910301 no 2615 0.204880575447741 901 674121
SGTC_3300 9124615 50.48 µM -0.825288777434057 0.221846843242206 no 2616 0.204603830857505 886 24824903
SGTC_2512 diallyl trisulfide 49.23 µM -0.825479930705151 0.221787538665861 no 2617 0.204549586044608 915 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_928 2764-0428 58.7 µM -0.825565168342097 0.221761096932497 no 2618 0.20452540036246 888 662578
SGTC_3066 9117245 49.47 µM -0.825918638766656 0.221651465404515 no 2619 0.204425123354427 860 17176980
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.826393809291195 0.221504136482025 no 2620 0.204290367029193 887 5282309
SGTC_67 0335-0847 266 µM -0.826925772875707 0.221339265031265 no 2621 0.204139567204238 902 4552207 YOR254C SEC63
SGTC_1945 st075991 56.6 µM -0.827347773999336 0.221208524174465 no 2622 0.204019986460846 891 1084980
SGTC_3169 9102970 49.47 µM -0.827507917339974 0.221158921470487 no 2623 0.203974618219078 896 17027839
SGTC_1929 genistein trimethyl ether 50.5 µM -0.828908503768407 0.220725375943348 no 2624 0.203578091539525 856 136420
SGTC_3172 9105863 49.47 µM -0.829038148100687 0.220685269724405 no 2625 0.203541410577502 890 2348785
SGTC_1360 1598-0022 39.8 µM -0.829546889876082 0.220527927867789 no 2626 0.203397507644958 884 761525
SGTC_2099 5377090 177.372 µM -0.82958299652056 0.22051676337599 no 2627 0.203387296810327 883 2243829
SGTC_1809 st050081 57.6 µM -0.829732262480965 0.220470612466413 no 2628 0.203345088156823 877 5036894
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.830024421038987 0.220380297222179 no 2629 0.203262488205068 889 5282362
SGTC_2086 5274770 176.623 µM -0.83175966208408 0.219844317789812 no 2630 0.202772308411621 873 689278
SGTC_2652 actinonin 100 µM -0.83208222309033 0.219744768015009 no 2631 0.202681267632977 880 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1022 4477-0945 21.3 µM -0.833272531057416 0.219377635524757 no 2632 0.202345522281525 858 4648966
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.833296907651106 0.219370120617871 no 2633 0.202338649951886 876 2333 A French combination drug.
SGTC_1018 4259-0013 28.1 µM -0.833406297520065 0.21933639932396 no 2634 0.202307812118277 886 6801262
SGTC_1937 st074714 47.2 µM -0.834828829059999 0.218898151029678 no 2635 0.201907045714082 892 17250970
SGTC_2145 5634607 200 µM -0.836317897622699 0.218439944359761 no 2636 0.201488043546176 895 308662
SGTC_1173 0443-0020 122 µM -0.838649188429867 0.217723684986139 no 2637 0.200833099737021 891 5331295
SGTC_2427 5545055 42.75 µM -0.839418396243133 0.21748765331401 no 2638 0.200617282099906 872 5372858
SGTC_3200 9114385 49.47 µM -0.839769938687995 0.217379831595093 no 2639 0.200518695757216 869 17018030 YLR208W SEC13
SGTC_1109 tnp00067 928.257 nM -0.839821290866096 0.217364083932704 no 2640 0.200504297020399 887 676295
SGTC_3274 9138298 49.47 µM -0.839842295341767 0.21735764288861 no 2641 0.200498407713665 907 17015756
SGTC_432 NS 1619 61.3 µM -0.843305112358501 0.216297274202325 no 2642 0.199528912173042 877 4552 A K+/calcium channel activator.
SGTC_2442 5158906 48.48 µM -0.843353225913011 0.216282562204599 no 2643 0.199515461577827 869 1893835
SGTC_2124 5246320 200 µM -0.843499977097157 0.216237692709054 no 2644 0.199474439279591 887 579342
SGTC_3185 9108267 49.47 µM -0.843601103898425 0.216206776105234 no 2645 0.199446173612335 882 4910486
SGTC_599 1935-0052 86.5 µM -0.845054321747618 0.215762779391676 no 2646 0.199040255120198 886 9557311
SGTC_2323 6148992 148.28 µM -0.846413069403284 0.21534812433256 no 2647 0.198661175062787 887 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2182 6325192 200 µM -0.847938110436473 0.21488327196223 no 2648 0.198236219419369 860 736248
SGTC_3275 9138069 49.47 µM -0.849739390907787 0.214334969716284 no 2649 0.197734996535257 894 17617007
SGTC_2079 5212404 121 µM -0.850075718331094 0.214232683281883 no 2650 0.197641495248399 863 758462
SGTC_3023 9089636 49.47 µM -0.850712808837045 0.214039004374508 no 2651 0.197464453072274 906 17249241
SGTC_1775 st081588 35.1725 µM -0.851148355052233 0.213906654677335 no 2652 0.197343473591908 884 1426443 YGL099W LSG1
SGTC_2495 cafestol 54.53 µM -0.853112061693808 0.213310533916506 no 2653 0.196798581604541 897 16667697 An anti-infammatory.
SGTC_2393 9031399 185.94 µM -0.854344004260428 0.212937049109694 no 2654 0.196457206052293 907 1526623 YDL150W RPC53
SGTC_2588 indole-3-carbinol 100 µM -0.854494500200964 0.212891449819847 no 2655 0.196415527717357 888 3712 Induces cell cycle arrest.
SGTC_2656 pseudo-anisatin 100 µM -0.856172091146521 0.212383536650394 no 2656 0.195951298703742 919 6708809 A neurotoxin.
SGTC_1235 benzylparaben 21.5 µM -0.857408823762472 0.212009553077966 no 2657 0.195609492233766 895 7180
SGTC_343 4130-2827 29.8 µM -0.858156006914053 0.211783794288862 no 2658 0.195403162309336 878 1118244
SGTC_842 0271-0008 11.1 µM -0.858755664027431 0.211602711771775 no 2659 0.195237666434957 876 1221709
SGTC_131 0141-0277 33.849 µM -0.859560449704255 0.211359827698562 no 2660 0.195015692230631 905 1547771
SGTC_98 0074-0023 107.663 µM -0.861627586322191 0.210736715387209 no 2661 0.194446242766902 878 3563821
SGTC_1192 1488-0095 21.4 µM -0.861729254306773 0.210706096681078 no 2662 0.194418261672908 923 915875
SGTC_737 1950-0117 57.9 µM -0.86228869063783 0.210537661463185 no 2663 0.194264337291151 891 5393513
SGTC_2279 7948423 32.93 µM -0.862509691159447 0.210471144355344 no 2664 0.194203551239695 876 1247112
SGTC_172 1112-0046 2.638 µM -0.863878269104518 0.210059502265003 no 2665 0.193827382805388 921 2802135 YIL048W NEO1
SGTC_1302 1159-0335 255 µM -0.864038438456941 0.210011357322658 no 2666 0.193783387578153 895 649284
SGTC_1143 3454-2408 5.08 µM -0.864326327365788 0.209924837750992 no 2667 0.193704325721396 854 X1143
SGTC_2569 tetrandrine 100 µM -0.866087223879823 0.209396089685428 no 2668 0.193221165464549 880 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_847 0342-0274 5.54 µM -0.866901699317 0.209151790751346 no 2669 0.192997936184578 898 18097
SGTC_2326 6164455 177.58 µM -0.868106362964125 0.208790764110084 no 2670 0.192668054022606 905 2888790
SGTC_1484 3473-2379 286 µM -0.868374143694023 0.208710562597609 no 2671 0.192594772436037 927 671917
SGTC_2210 7115885 190.385 µM -0.869463048816663 0.208384617787786 no 2672 0.192296955292168 899 2927039
SGTC_1953 st076800 12.1 µM -0.869463651505002 0.208384437466688 no 2673 0.192296790534054 880 297591
SGTC_1852 st056254 31.4 µM -0.869551503628961 0.20835815356985 no 2674 0.192272775147186 871 442583
SGTC_592 k241-0073 46.5 µM -0.871832089752102 0.207676524604108 no 2675 0.191649992814235 890 4230158
SGTC_1285 0929-0069 65.5 µM -0.872396920382096 0.207507909964539 no 2676 0.191495939995113 887 1206237
SGTC_2626 ethyl orsellinate 100 µM -0.873099450243733 0.207298301951916 no 2677 0.191304436765675 912 75653 A natural product.
SGTC_3201 9113999 49.47 µM -0.873882842476357 0.207064715409172 no 2678 0.191091029672844 908 16649224
SGTC_2334 9017922 200 µM -0.874619778892596 0.206845122952849 no 2679 0.190890411111766 895 3163164
SGTC_10 0279-0212 42.575 µM -0.875474358237634 0.206590647923855 no 2680 0.19065792810636 887 39851 YBR002C RER2
SGTC_2790 5423970 71.43 µM -0.875817637740025 0.206488479024399 no 2681 0.190564589995604 898 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1501 4491-0275 38.4 µM -0.877045915483986 0.206123156896155 no 2682 0.190230849616819 890 5104718
SGTC_1234 0326-0494 15.5 µM -0.878199641397399 0.205780357729471 no 2683 0.189917693296362 900 1547813
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.879439488825106 0.205412347200843 no 2684 0.189581514501143 919 229346 A bile salt which induces apoptosis.
SGTC_972 1319-0219 195 µM -0.88107977517238 0.204926079780558 no 2685 0.189137321551516 898 23903702
SGTC_390 dec-rvkr-cmk 16.7 µM -0.882123742169197 0.204616949605865 no 2686 0.188854947170724 895 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_670 4204-0025 119 µM -0.884248614030274 0.203988609252811 no 2687 0.188281010367303 895 719039
SGTC_1687 st020778 55.3625 µM -0.884631632556042 0.203875470253546 no 2688 0.18817767004334 894 4259299
SGTC_748 act1.228 77.9 µM -0.886369201965882 0.203362683295373 no 2689 0.187709304779449 892 4421505 YNR035C ARC35
SGTC_1025 k007-0731 70 µM -0.891249051736617 0.20192667617131 no 2690 0.186397787282863 890 6256118
SGTC_1740 st038286 13.222 µM -0.891334916940669 0.201901462842229 no 2691 0.186374760927669 890 716786
SGTC_1238 0333-0287 48.8 µM -0.8916933025611 0.201796247380583 no 2692 0.186278672170278 897 7226
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.892055842756752 0.201689845624438 no 2693 0.186181500744798 915 364106
SGTC_277 nystatin 15.5 µM -0.892185977724731 0.201651660569456 no 2694 0.18614662841283 922 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1756 st041558 35.5 µM -0.89322305047878 0.201347510680394 no 2695 0.185868868214109 936 3955792
SGTC_1893 st059353 36.1 µM -0.894416956187622 0.200997705960211 no 2696 0.185549421757225 939 3112488
SGTC_197 4544-0043 41.561 µM -0.895510642999288 0.200677584731886 no 2697 0.185257089500935 906 896523
SGTC_3074 9116018 49.47 µM -0.895720619959848 0.200616159689351 no 2698 0.185200997366316 945 17027303
SGTC_3165 9101544 49.47 µM -0.896118656513762 0.200499752127863 no 2699 0.185094696938338 906 5002184
SGTC_2931 9014674 55.67 µM -0.89671978507884 0.200324026316174 no 2700 0.184934230215876 910 2996810
SGTC_814 3342-0569 96 µM -0.898675626308153 0.199752922715685 no 2701 0.184412731648852 896 4346283
SGTC_2505 galangin 7.89 µM -0.899786607650044 0.199428953972244 no 2702 0.184116911355883 902 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1738 st035555 74 µM -0.90263766657712 0.19859901696293 no 2703 0.183359114383915 910 5331140
SGTC_3072 9116419 49.47 µM -0.904331795725706 0.198106847847327 no 2704 0.182909745900804 909 17170162
SGTC_2424 5537928 59.2 µM -0.904434490275795 0.198077037282458 no 2705 0.182882528239336 898 5382802
SGTC_1123 mangostin 811.285 nM -0.905745792227406 0.197696625723456 no 2706 0.18253520941828 848 5281650 An antioxidant.
SGTC_2571 chrysanthemic acid 100 µM -0.906349601208752 0.197521607984487 no 2707 0.182375419787646 934 2743 An insecticide.
SGTC_1647 st011722 22.4 µM -0.907520750917841 0.197182410215802 no 2708 0.182065740578495 890 2854783
SGTC_3305 9127027 53.8275 µM -0.908418961949997 0.196922502091896 no 2709 0.18182845559663 903 41905295
SGTC_70 0141-0289 43.283 µM -0.909743814231027 0.196539518992351 no 2710 0.181478815889806 870 352408
SGTC_309 k408-0051 1.48 µM -0.911175204411856 0.196126245933296 no 2711 0.181101533255918 893 3640463
SGTC_150 3970-0969 77.2 µM -0.91189489753772 0.195918654342827 no 2712 0.180912023918811 927 6615640
SGTC_2119 5528445 120.635 µM -0.912049300508023 0.195874135016346 no 2713 0.180871382781534 921 791935
SGTC_763 3453-1109 128 µM -0.913236861317862 0.195531928378625 no 2714 0.180558990564781 893 1560353
SGTC_2189 6047310 154.431 µM -0.913279328622147 0.195519697759333 no 2715 0.180547825655481 894 711535
SGTC_428 3448-4153 16.5 µM -0.913696646482 0.195399534581386 no 2716 0.180438133319745 887 3834874
SGTC_1075 aripiprazole 15.2 µM -0.914242738354846 0.195242359783174 no 2717 0.180294655796241 915 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2952 9073731 13.78 µM -0.914768353275149 0.195091151190285 no 2718 0.180156625924697 923 16457353
SGTC_1753 st043925 64 µM -0.915137517756207 0.194984992735519 no 2719 0.180059720614168 920 670181
SGTC_719 2810-4230 27.3 µM -0.916155334995845 0.194692486985391 no 2720 0.179792714135468 910 721079
SGTC_995 3931-2021 34.6 µM -0.920144489957327 0.193548638232527 no 2721 0.178748628877158 936 730143
SGTC_2895 9054447 58.44 µM -0.920328681655284 0.193495922363958 no 2722 0.178700512585116 925 2697450
SGTC_2205 7238770 200 µM -0.922070918314653 0.192997725632633 no 2723 0.178245792553216 903 279867
SGTC_2857 9024691 58.44 µM -0.922220567291548 0.192954969711981 no 2724 0.178206768528345 922 16478292
SGTC_744 1594-0068 283 µM -0.922759356701794 0.192801081140463 no 2725 0.178066312792747 912 668392
SGTC_3161 9100388 49.47 µM -0.924751124080384 0.192232845465791 no 2726 0.17754768979187 919 25236368
SGTC_1761 st044296 37 µM -0.925313278884282 0.192072652645844 no 2727 0.177401486737073 913 1826700
SGTC_2673 kobusone 100 µM -0.92606522546694 0.191858504110589 no 2728 0.17720604223635 941 6710676 An epoxy ketone and protein crosslinker.
SGTC_2607 solasodine 47.35 µM -0.928348260975469 0.191209209484847 no 2729 0.176613473744818 911 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2784 7567673 72.73 µM -0.930418061044561 0.190621724715424 no 2730 0.176077335413224 896 3471247
SGTC_2080 5212524 12.4 µM -0.932288533546259 0.190091770580688 no 2731 0.175593715972513 900 260183
SGTC_2394 5221648 200 µM -0.934366647910015 0.18950404898601 no 2732 0.175057397873454 925 788586
SGTC_195 4234-0266 16.654 µM -0.935805703327748 0.189097718718531 no 2733 0.174686617242882 911 2303354
SGTC_2756 carbadox 75.1 µM -0.936156111792485 0.188998859024541 no 2734 0.174596408093832 889 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1975 st070967 30.8 µM -0.936571071715737 0.188881828803813 no 2735 0.174489619083362 905 261391
SGTC_2425 5628681 7.85 µM -0.937165685116595 0.188714209166143 no 2736 0.174336668981945 913 5714958
SGTC_809 3998-0021 90 µM -0.937274565775005 0.188683525987435 no 2737 0.174308671261606 927 715485
SGTC_1331 1472-0049 76.2 µM -0.938093607194497 0.188452814119188 no 2738 0.174098153422427 912 24051409
SGTC_1106 tegaserod maleate 11.7 µM -0.938769884042654 0.188262448116538 no 2739 0.173924452162823 913 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_3276 9139060 49.47 µM -0.939979743947728 0.187922179282376 no 2740 0.17361397548403 930 4870619
SGTC_3207 9114163 49.47 µM -0.940277571356728 0.187838474652878 no 2741 0.173537600540799 936 849233
SGTC_2868 9035608 32.47 µM -0.940747043792077 0.187706575814109 no 2742 0.173417252323479 908 6462614
SGTC_553 k007-0256 45.7 µM -0.941265058497955 0.187561105376792 no 2743 0.173284522069525 916 6287000
SGTC_1860 st056228 74.6 µM -0.941885496041145 0.187386963965481 no 2744 0.173125633297953 926 688679
SGTC_3110 9122132 49.47 µM -0.942390288192149 0.18724535510589 no 2745 0.172996428810404 906 918317
SGTC_3335 9143315 29.6265 µM -0.943514433611938 0.186930237506553 no 2746 0.172708918051268 889 4899691
SGTC_155 k072-0202 43.6 µM -0.943613888360668 0.186902374411401 no 2747 0.172683496238958 905 5857737
SGTC_488 nitrendipine 139 µM -0.943705973593565 0.18687657824038 no 2748 0.172659960289256 929 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1039 k821-0043 94 µM -0.946170107598253 0.186187109934404 no 2749 0.172030915036794 916 15992768
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.947197906083303 0.18589999692144 no 2750 0.171768971084482 898 688667
SGTC_732 3970-1727 52.7 µM -0.948650439442779 0.185494703734048 no 2751 0.171399214172669 920 1275699
SGTC_2979 9012552 45.46 µM -0.949262812266226 0.185324000845739 no 2752 0.17124348110888 930 17100905
SGTC_113 0099-0221 2.5 µM -0.950489315162213 0.184982398647347 no 2753 0.170931840254401 898 89219
SGTC_2824 7998404 51.95 µM -0.950626122579439 0.184944319691936 no 2754 0.17089710150708 925 837851
SGTC_252 miconazole 1.30953 nM -0.954226950290628 0.183943817727743 no 2755 0.169984387778845 897 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1782 st039423 80.636 µM -0.954529863475505 0.183859806259465 no 2756 0.169907750115799 930 2068169
SGTC_1010 4112-3296 15.2 µM -0.95477155142468 0.183792792449861 no 2757 0.169846618455254 923 704384
SGTC_480 am 92016 50 µM -0.955142480384606 0.183689973053524 no 2758 0.169752824484454 937 2129 K+ channel blocker.
SGTC_572 0960-0087 17.7 µM -0.955436088277919 0.183608612032838 no 2759 0.16967860565835 931 6796365
SGTC_1904 st060225 78 µM -0.955627171898756 0.183555673347208 no 2760 0.169630314317975 904 66595
SGTC_2199 6590217 200 µM -0.956036362360735 0.183442341338792 no 2761 0.169526931889782 860 703109
SGTC_1881 5652484 16 µM -0.956185381709512 0.183401078824287 no 2762 0.169489292028777 933 2255129
SGTC_2564 betulinic acid 100 µM -0.956984767123379 0.183179832847952 no 2763 0.169287471836854 957 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1843 st055809 45.5 µM -0.957030898552815 0.183167070130554 no 2764 0.169275829782066 931 16413835
SGTC_2958 9077254 16.72 µM -0.958563574466249 0.18274335551469 no 2765 0.168889325040722 923 16457351
SGTC_1799 st045822 46.1415 µM -0.959535287063839 0.182475038757019 no 2766 0.168644575932553 876 3674992
SGTC_2291 7917025 104.35 µM -0.959718577292283 0.18242445485026 no 2767 0.168598435464977 909 2964612
SGTC_820 1582-0060 59.9 µM -0.96127218934735 0.181996045378895 no 2768 0.168207663716804 923 3848840
SGTC_1664 st014217 9.02 µM -0.961464009432141 0.181943194539158 no 2769 0.168159456678671 905 3982782
SGTC_1979 st071809 45.3 µM -0.96416445273887 0.18120017930593 no 2770 0.1674817415408 943 4976333
SGTC_2893 9048488 25.97 µM -0.965101633699417 0.18094276289931 no 2771 0.167246954380854 938 6467338
SGTC_1107 amlodipine 47 µM -0.965417112577522 0.180856161590632 no 2772 0.167167966820976 844 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2313 7726885 200 µM -0.967375412920078 0.180319174831211 no 2773 0.166678198339944 920 726423
SGTC_2012 4023501 200 µM -0.968083221999471 0.180125332471792 no 2774 0.166501404228208 923 3477460
SGTC_1638 st008370 60.6 µM -0.96815712609643 0.180105100456441 no 2775 0.1664829516999 894 24207134
SGTC_3008 9078912 71.4286 µM -0.968969929244161 0.179882681273511 no 2776 0.166280096431535 937 16648731
SGTC_3005 9076496 71.4286 µM -0.970557999026793 0.179448612636583 no 2777 0.165884214912539 921 21368410
SGTC_1442 4112-3290 3 µM -0.970993491407282 0.179329694224697 no 2778 0.165775759841792 942 704353
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.972586837305304 0.178895027169219 no 2779 0.165379343581424 907 4330530
SGTC_810 3825-7150 143 µM -0.974759180235993 0.178303478180668 no 2780 0.164839864803035 887 22330411 YGL099W LSG1
SGTC_1920 st075728 45.7 µM -0.975080408920594 0.178216109378918 no 2781 0.164760187844128 879 3400306
SGTC_1047 2043-3044 82 µM -0.97612792162643 0.177931391030299 no 2782 0.16450053812142 956 669592
SGTC_2480 5767542 37.17 µM -0.978897097199495 0.177180099941851 no 2783 0.163815413310501 905 2867358
SGTC_1983 st071813 46.9 µM -0.979318049505542 0.177066069183056 no 2784 0.163711427423673 925 11838595
SGTC_1386 3228-0095 33.8 µM -0.97933244599574 0.177062170172544 no 2785 0.163707871883721 929 870181
SGTC_2487 5918373 44.05 µM -0.979551261111712 0.17700291501456 no 2786 0.163653836696561 913 2876279
SGTC_1669 st015249 58.4 µM -0.979750107809835 0.176949078174535 no 2787 0.163604742643841 945 722793
SGTC_901 1112-0062 60.1 µM -0.982279979048806 0.176265030549835 no 2788 0.162980967544433 906 1908457
SGTC_707 0865-0008 204 µM -0.982528486116915 0.17619792752306 no 2789 0.162919778160041 945 723043
SGTC_1525 8-methoxypsoralen 92.5 µM -0.98253292347464 0.17619672947417 no 2790 0.162918685694325 953 4114 Related to psoralen; DNA damaging agent.
SGTC_1845 st056753 3.01 µM -0.982715454297517 0.176147452170704 no 2791 0.16287375121698 921 5375839
SGTC_962 1254-0300 21.5 µM -0.98408706827413 0.175777440734226 no 2792 0.162536352335696 907 7340576
SGTC_618 k072-0232 33.2 µM -0.985888379123046 0.175292261217192 no 2793 0.162093945021491 908 5872756 YGL099W LSG1
SGTC_1510 1123-0200 71.5 µM -0.986617048642537 0.175096236987518 no 2794 0.161915204607241 930 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_471 1-acyl-paf 4 µM -0.987675921499728 0.1748116305236 no 2795 0.161655695277896 912 16759367
SGTC_2342 7990637 118.86 µM -0.988347454359085 0.174631286508026 no 2796 0.161491256082729 966 2033102 YER133W GLC7
SGTC_1859 st055998 20 µM -0.989941437889514 0.174203686258771 no 2797 0.161101371940443 942 676301
SGTC_723 4182-0001 115 µM -0.992261117200394 0.173582601535695 no 2798 0.160535082787495 933 744821 YLR208W SEC13
SGTC_3167 9103034 49.47 µM -0.992692650040032 0.173467216004508 no 2799 0.160429878937367 933 5127859
SGTC_1391 3442-0225 151 µM -0.99283019444628 0.17343044891646 no 2800 0.160396356309634 917 5227075
SGTC_8 0354-0001 70 µM -0.993905537104798 0.173143169355312 no 2801 0.160134429202066 926 4993152
SGTC_275 trichlorophene 5.69 µM -0.995903850167178 0.172610122170564 no 2802 0.159648432214622 901 62616
SGTC_967 1306-0166 352 µM -0.99592628048565 0.172604144859324 no 2803 0.159642982563431 917 4437607
SGTC_1266 0828-0227 32.9 µM -0.996505757469332 0.17244976951551 no 2804 0.159502235523952 942 3913820
SGTC_1905 st060207 84.5 µM -0.996585809072096 0.172428450324115 no 2805 0.159482798471222 916 1948547
SGTC_1225 1216-0074 20.6 µM -0.998291562375478 0.171974576924115 no 2806 0.159068998948216 932 4241466
SGTC_2865 9030313 51.95 µM -1.00326839011619 0.17065468736559 no 2807 0.157865691615614 939 42562754
SGTC_2055 5235184 200 µM -1.00437964914288 0.170360861662879 no 2808 0.157597827707551 915 2836034
SGTC_897 1000-0139 31.4 µM -1.00463894514543 0.170292348396971 no 2809 0.157535368586541 937 6151020
SGTC_2373 9071805 200 µM -1.00667040891953 0.169756189767294 no 2810 0.15704659337817 956 10149009
SGTC_1072 oxiconazole 14.9 nM -1.00714819619575 0.169630246111893 no 2811 0.156931781620227 915 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2877 9040724 71.43 µM -1.00767218082597 0.169492193868917 no 2812 0.156805932192379 941 6463895
SGTC_526 4469-0568 170 µM -1.0098128857575 0.168928939622482 no 2813 0.156292472678936 935 2901964
SGTC_3227 9130768 49.47 µM -1.01127590255036 0.168544688646734 no 2814 0.15594219809875 967 17720899
SGTC_2093 5331342 194.4 µM -1.01314547680293 0.168054476742737 no 2815 0.155495339486122 921 33839
SGTC_237 nikkomycin 200 µM -1.01704222227179 0.167035682651718 no 2816 0.154566672032641 960 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1290 0986-0249 10.2 µM -1.01893044100781 0.166543448266564 no 2817 0.154117995333278 931 53329
SGTC_400 oxethazaine 37.5 µM -1.01950621447212 0.166393537991834 no 2818 0.153981352186464 929 4621 A local anesthetic.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.02344493589613 0.165370377049697 no 2819 0.153048761164479 944 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3085 9117376 49.47 µM -1.0240322831963 0.16521815145617 no 2820 0.152910013434112 923 16480349
SGTC_2087 5276107 200 µM -1.02465028286591 0.165058079487652 no 2821 0.152764114834331 920 144405
SGTC_413 propylparaben 100 µM -1.02479152685694 0.165021509096978 no 2822 0.152730782636618 930 7175 A pharmaceutical preservative.
SGTC_2160 5660466 132.927 µM -1.02511601316997 0.164937514129143 no 2823 0.152654225319145 952 2859134
SGTC_1303 1160-0052 261 µM -1.0254899277766 0.164840758729693 no 2824 0.15256603776679 906 3562476
SGTC_2395 5646831 180.19 µM -1.02617594460118 0.16466333832867 no 2825 0.152404328994682 962 6808628
SGTC_1717 st033143 58.0435 µM -1.02672233827344 0.16452211637399 no 2826 0.152275613786556 948 674616
SGTC_2705 st078069 42.8 µM -1.0277049158506 0.164268355059559 no 2827 0.152044327367737 944 1530061
SGTC_504 lovastatin 124 µM -1.02810960897663 0.164163912504182 no 2828 0.151949135562037 947 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_955 1216-0110 33 µM -1.02990162743946 0.163701948969055 no 2829 0.151528093352046 939 3619719
SGTC_1897 st060201 15 µM -1.03049098374659 0.163550203694415 no 2830 0.151389791284247 942 611878
SGTC_1030 k029-0042 36.7 µM -1.03185816880354 0.163198537798279 no 2831 0.151069282344077 932 6080581
SGTC_228 caffeine 993.056 µM -1.0325342098073 0.163024828935663 no 2832 0.150910965128776 928 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1040 k898-0338 155 µM -1.03469058652052 0.162471550963449 no 2833 0.150406716816503 933 20969351
SGTC_397 arbidol 50 µM -1.03845715667828 0.161508068232144 no 2834 0.149528635759824 937 131410 A RNA synthesis inhibitor.
SGTC_2267 7931562 200 µM -1.039138806369 0.161334102220011 no 2835 0.149370092621712 940 934880
SGTC_2959 9079155 11 µM -1.03930190730966 0.161292494830921 no 2836 0.149332174040218 928 16189457
SGTC_1042 0350-0096 82 µM -1.03935212958864 0.161279684432678 no 2837 0.149320499389642 939 3122515
SGTC_895 0964-0006 13.7 µM -1.03992486124187 0.161133642412843 no 2838 0.149187405521421 956 6738897
SGTC_1286 0929-0070 131 µM -1.04336381434472 0.16025855185556 no 2839 0.148389913030418 929 1420408
SGTC_419 nsc-638432 893 µM -1.04470235145988 0.159918783440075 no 2840 0.148080278853585 936 368090
SGTC_838 0109-0203 71.4 µM -1.04492410166274 0.159862540862285 no 2841 0.148029024751074 923 759422
SGTC_389 tpck 16.7 µM -1.0458328390344 0.159632192673701 no 2842 0.147819108314758 947 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1752 st044819 83.042 µM -1.04709116387156 0.159313589302529 no 2843 0.147528767129048 933 441209 YML126C ERG13
SGTC_3163 9099914 49.47 µM -1.04948627679036 0.158708306624359 no 2844 0.146977184018567 969 16268368
SGTC_743 1275-0778 158 µM -1.04976865000523 0.158637045957654 no 2845 0.146912246067559 943 2849257 YMR203W TOM40
SGTC_1452 4194-0072 190 µM -1.0510306344461 0.158318823711794 no 2846 0.146622260114656 950 1343545
SGTC_3035 9091303 49.47 µM -1.05365455781243 0.15765851632752 no 2847 0.146020550493214 961 25237002
SGTC_2411 st077133 39.94 µM -1.05386786593806 0.157604917209263 no 2848 0.145971708383693 965 1403142 YNL221C POP1
SGTC_3349 9149703 23.001 µM -1.05593863232509 0.157085206570418 no 2849 0.145498126368838 943 4910494
SGTC_1863 st057641 20.1 µM -1.05649049162592 0.15694689410529 no 2850 0.145372091325276 961 3921635
SGTC_1033 k072-0102 21.3 µM -1.05679936071756 0.156869517242203 no 2851 0.145301583073268 930 5965931
SGTC_1426 4048-4480 71.7 µM -1.05792777512314 0.156587043992448 no 2852 0.145044185630283 947 14224343
SGTC_1152 3909-8331 15.9 µM -1.0593324068657 0.156235894058657 no 2853 0.144724210560954 926 16001939
SGTC_1518 st038567 90.8 µM -1.0595228941933 0.156188313289492 no 2854 0.144680854189728 952 77966
SGTC_841 0251-0215 91.2 µM -1.06073985248348 0.155884561401895 no 2855 0.144404071681256 947 3888614
SGTC_209 4077-0173 175.592 µM -1.06232985910093 0.155488284112583 no 2856 0.144042981833812 944 15993494
SGTC_1571 st070080 73.4 µM -1.0631091350977 0.155294308088688 no 2857 0.143866231112688 930 4315245
SGTC_2481 5478948 45.16 µM -1.06772980999607 0.154147420133166 no 2858 0.142821203783842 944 77792
SGTC_2227 7312221 64.1025 µM -1.06834238947799 0.153995794770655 no 2859 0.142683046936564 968 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1355 1499-0035 1.68 µM -1.0685645048931 0.153940841261954 no 2860 0.14263297492416 967 1548538
SGTC_2529 gangaleoidin 93.61 µM -1.06912053251077 0.153803331544087 no 2861 0.142507680386256 955 4565183
SGTC_2007 4011539 71.82 µM -1.07171275725292 0.15316332867775 no 2862 0.1419245345106 942 45595301
SGTC_1507 4075-3230 155 µM -1.07303417982318 0.152837758472161 no 2863 0.141627890385099 933 659771
SGTC_2020 4017018 200 µM -1.07318251865558 0.152801239634118 no 2864 0.141594616270095 976 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_450 aminopyrene 156 nM -1.07491652859872 0.152374781117347 no 2865 0.141206050600987 939 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1437 4092-1038 11.6 µM -1.07515307209606 0.152316667433 no 2866 0.141153100834163 950 3977136
SGTC_403 arphamenine a 50 µM -1.07638477711422 0.152014301610538 no 2867 0.140877603825889 953 5487158 An arginine aminopeptidase inhibitor.
SGTC_1278 0874-0585 172 µM -1.07639156079937 0.152012637418313 no 2868 0.140876087521262 956 766306
SGTC_2037 5169046 200 µM -1.07782357466905 0.151661602746476 no 2869 0.140556248389147 953 5718022
SGTC_2090 5301565 104.445 µM -1.07868787130983 0.151449995556527 no 2870 0.140363447149107 947 2056344
SGTC_1779 st039427 55 µM -1.07923202635578 0.151316869924084 no 2871 0.140242153021771 942 1124498
SGTC_2733 amorolfine 100 µM -1.08008877879926 0.151107426209361 no 2872 0.140051324126131 991 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1523 st012844 44.7 µM -1.08311243079684 0.150369799385203 no 2873 0.139379261017435 965 4274103
SGTC_3022 9087993 49.47 µM -1.08481539351062 0.149955415633698 no 2874 0.139001713138409 950 17173644
SGTC_1962 st076595 64.5 µM -1.08641955138416 0.14956577131007 no 2875 0.138646707722237 940 279619
SGTC_909 3448-9333 149 µM -1.08706531709311 0.149409107990278 no 2876 0.138503972164871 953 3344074
SGTC_1680 diphenhydramine 100 µM -1.08775546207607 0.149241799353459 no 2877 0.13835153804704 927 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_253 dyclonine 31.25 µM -1.09046667954481 0.14858574299521 no 2878 0.137753811646554 960 3180 An oral anasthetic.
SGTC_2328 6201408 200 µM -1.09058749972268 0.148556552055086 no 2879 0.137727216197654 976 2890418
SGTC_1512 0259-0544 12.2 µM -1.09140803779105 0.148358406178131 no 2880 0.137546688590839 935 18476
SGTC_629 3448-6466 76.7 µM -1.09382684020193 0.147775335880329 no 2881 0.137015465054436 951 573744
SGTC_3130 9127414 49.47 µM -1.09492568229593 0.147510959397035 no 2882 0.136774598265253 957 1494646
SGTC_1384 3089-0840 101 µM -1.095285962492 0.147424346618572 no 2883 0.136695687699044 940 1069836
SGTC_1467 k284-1082 293 µM -1.095809941254 0.147298440890493 no 2884 0.136580978529502 952 3334705
SGTC_2798 7813637 45.45 µM -1.09637594536765 0.147162517974139 no 2885 0.136457143169011 947 956368
SGTC_1316 1272-0050 65.9 µM -1.09677878810768 0.147065828641306 no 2886 0.136369052486226 951 7340392
SGTC_509 pifithrin 175 µM -1.10039547772335 0.146199667735272 no 2887 0.135579924002871 982 4817 A p53 inhibitor.
SGTC_789 1309-1135 70.6 µM -1.10231553764122 0.145741227713788 no 2888 0.13516225836872 943 3092424
SGTC_99 0109-0120 622.8 µM -1.10270327951289 0.145648766551518 no 2889 0.135078021069298 935 759414
SGTC_1778 st046819 58.9 µM -1.10309919632761 0.145554396690185 no 2890 0.134992044911471 958 671715
SGTC_2904 7225135 42.03 µM -1.10427032647745 0.14527548942329 no 2891 0.134737945403339 977 4446116
SGTC_2285 7945142 200 µM -1.10661210789738 0.144718867907251 no 2892 0.134230835077828 941 2970608
SGTC_1272 0839-0021 27 µM -1.10732665163435 0.144549313328035 no 2893 0.1340763627339 983 5027250
SGTC_285 1486-1325 46 µM -1.1073923713529 0.144533725374094 no 2894 0.134062161371074 937 22310230
SGTC_549 1661-1316 519 µM -1.10813489722327 0.144357685547825 no 2895 0.13390178088188 962 2857282
SGTC_1628 st004252 77.7 µM -1.10887995824441 0.144181189989985 no 2896 0.133740985403629 938 692968
SGTC_1546 5-methoxyflavanone 78.7 µM -1.11285766661559 0.143241383377892 no 2897 0.132884781966433 948 147795
SGTC_1810 st050138 53 µM -1.11447971058077 0.142859335942569 no 2898 0.132536721973293 965 3444541
SGTC_2805 7950783 58.44 µM -1.11493645194229 0.142751881943115 no 2899 0.132438827343127 944 1178958 YDL195W SEC31
SGTC_3036 9090181 49.47 µM -1.11679575258776 0.142315022718635 no 2900 0.132040832669656 967 25236586
SGTC_1440 4100-1550 40 µM -1.11685998673658 0.14229994651559 no 2901 0.132027097712447 968 742806
SGTC_690 glyoxal 20.3 µM -1.11829282342076 0.141963930628125 no 2902 0.13172097549334 957 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1715 st032160 10.2275 µM -1.1186307918278 0.141884751697054 no 2903 0.131648840773378 949 5289825
SGTC_3088 9117578 49.47 µM -1.12126288304673 0.141269131103394 no 2904 0.131087989909524 999 678341
SGTC_2387 9077560 195.08 µM -1.12231463169307 0.141023644387821 no 2905 0.130864343582686 962 5303272
SGTC_81 0411-0046 9.971 µM -1.12355764017468 0.140733889292787 no 2906 0.13060036747024 944 12925265
SGTC_1613 st002381 52.1 µM -1.12617794399288 0.140124400006031 no 2907 0.130045103668625 948 551167
SGTC_2085 5307070 144.047 µM -1.13543351047772 0.137985900430649 no 2908 0.128096862856149 977 2840351
SGTC_2158 5657123 3.6195 µM -1.13841447745488 0.137301911969417 no 2909 0.12747372578845 984 2858827
SGTC_2433 5607874 27.82 µM -1.13845300546615 0.137293086828647 no 2910 0.127465685770489 941 2252428
SGTC_2420 aureobasidin a 50 nM -1.14065945706137 0.136788328219498 no 2911 0.127005832152826 965 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1111 tnp00062 510.699 nM -1.14066449545224 0.136787177066261 no 2912 0.127004783408724 950 676306
SGTC_3220 9131269 49.47 µM -1.14520335905883 0.135752843398227 no 2913 0.126062463614324 964 17722206
SGTC_2812 7970281 58.44 µM -1.14919458842267 0.134847743801886 no 2914 0.125237875911244 989 2233435
SGTC_347 4534-1311 26.2 µM -1.1528197270826 0.134029258831022 no 2915 0.124492192801845 963 2862016
SGTC_1380 2291-0730 164 µM -1.15293854895051 0.134002489091208 no 2916 0.124467804056322 969 2999191
SGTC_2611 pyromycin 23.93 µM -1.15303988147014 0.133979662482565 no 2917 0.124447007721007 952 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2088 5278280 127.392 µM -1.1541678075305 0.133725761292007 no 2918 0.124215689012555 966 791502
SGTC_2654 protoveratrine a 100 µM -1.1555975107598 0.133404404365774 no 2919 0.123922913341849 972 5702278 A heart drug and vasodilator.
SGTC_2280 7785178 200 µM -1.15618097448169 0.1332734109488 no 2920 0.123803570093922 954 2954328
SGTC_1325 1431-0015 227 µM -1.15713309494653 0.133059840519548 no 2921 0.123608993614325 949 1103340
SGTC_159 3970-0959 50 µM -1.15751050850871 0.132975248002548 no 2922 0.1235319242262 940 6615653
SGTC_1454 4239-0054 42.6 µM -1.15763714095206 0.13294687322539 no 2923 0.123506072907049 962 1340767
SGTC_1274 0865-0114 173 µM -1.15967009311046 0.132491916277666 no 2924 0.123091575505996 964 870624
SGTC_530 4358-1714 28 µM -1.16014201975572 0.132386456816356 no 2925 0.122995494273927 945 1564641
SGTC_1527 coumarin 137 µM -1.1624186500113 0.131878520621657 no 2926 0.122532725646413 986 323 A hepatotoxic, DNA x-linker.
SGTC_318 1488-0629 67.2 µM -1.16535787561262 0.131224744022826 no 2927 0.121937080513585 981 3662576
SGTC_953 1188-0045 9.7 µM -1.16616883732642 0.13104475519984 no 2928 0.121773094651163 959 6144426
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.16763773437377 0.130719175394031 no 2929 0.121476461275684 974 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2759 disulfiram 3.38 µM -1.16911253383861 0.130392850310889 no 2930 0.121179147347933 942 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.16940417403178 0.130328386624822 no 2931 0.121120414465585 964 1377
SGTC_1082 camptothecin 424.86 nM -1.17072371533095 0.130036992868186 no 2932 0.120854924742857 935 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1392 3455-1037 33.9 µM -1.17101782236391 0.129972106837302 no 2933 0.120795806707289 948 981132
SGTC_1883 5-benzylidenerhodanine 20 µM -1.17136268104984 0.12989605250462 no 2934 0.120726513083515 953 1273210
SGTC_2516 gossypol 71.55 µM -1.17806986542622 0.128422990544369 no 2935 0.119384377231316 980 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_781 4335-2806 94.4 µM -1.18059941568014 0.127870462421562 no 2936 0.118880947936734 1008 845254
SGTC_760 0568-0725 82.9 µM -1.18083760036897 0.127818521109459 no 2937 0.118833621940567 981 3916171
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.18283785062261 0.127382901959958 no 2938 0.118436708228633 966 6708760
SGTC_1195 1502-0147 41.1 µM -1.18434172858764 0.127056064671185 no 2939 0.118138908422132 948 817940
SGTC_2600 tangeritin 87.95 µM -1.18590336656228 0.126717292547414 no 2940 0.117830231764172 960 68077 A bioactive flavone.
SGTC_1444 4112-3581 28 µM -1.18674594525607 0.12653477018565 no 2941 0.117663923106204 966 2877249
SGTC_1058 3448-5425 97.3 µM -1.18753761216148 0.126363443458182 no 2942 0.11750781489857 967 7279705
SGTC_1150 3909-7983 10.9 µM -1.19107364891393 0.125600174063127 no 2943 0.116812336773485 974 23965914
SGTC_176 1486-1328 72.834 µM -1.19138952837464 0.125532146922417 no 2944 0.116750350943704 960 22310231
SGTC_2956 9076196 2.52 µM -1.19371637727091 0.125031833872575 no 2945 0.116294465975221 986 16423868
SGTC_2153 5569715 200 µM -1.19601397483555 0.12453917865231 no 2946 0.115845552804523 986 2054701
SGTC_2366 9070441 60.58 µM -1.19739091345185 0.124244584050854 no 2947 0.115577111831262 968 6837235
SGTC_3302 9125395 16.351 µM -1.19858132618134 0.123990289622251 no 2948 0.115345391429899 964 17599668
SGTC_2782 7736369 71.43 µM -1.20063033326466 0.123553436843137 no 2949 0.114947314580555 977 2950836 YOL077C BRX1
SGTC_18 0111-0177 500 nM -1.20135826187178 0.123398500686207 no 2950 0.114806129620894 983 721752
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.20176912581407 0.123311110359422 no 2951 0.114726495238934 976 616764
SGTC_235 0330-0087 5 mM -1.20233778898981 0.123190227859766 no 2952 0.114616340784058 980 46494818 YHR062C RPP1
SGTC_1801 st050089 28.441 µM -1.20331980046185 0.122981674211277 no 2953 0.11442629482729 975 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.20593061596816 0.122428409289341 no 2954 0.113922122285238 1000 5106787 A p450 inhibitor.
SGTC_703 3875-0075 71.8 µM -1.20627881622181 0.122354753461663 no 2955 0.113855001421422 1013 2850814
SGTC_2241 6772625 37.8075 µM -1.20776727707493 0.122040245608211 no 2956 0.113568395816455 959 2285411
SGTC_1547 harmine 94.2 µM -1.20819093863724 0.121950830923219 no 2957 0.113486913204917 964 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3070 9117005 49.47 µM -1.20831776051221 0.121924073844317 no 2958 0.113462529728104 1017 8779016
SGTC_3193 9111931 49.47 µM -1.21135227605464 0.121285076455998 no 2959 0.112880210775501 990 17087244
SGTC_1046 2001-0062 216 µM -1.21534456676635 0.120447986774946 no 2960 0.112117350382882 984 739778
SGTC_1902 st060212 70.5 µM -1.21718748760379 0.120062945349841 no 2961 0.111766444862746 952 688944
SGTC_510 ag-490 170 µM -1.22340820606247 0.118769659659387 no 2962 0.110587777736681 997 5328779
SGTC_3171 9103192 49.47 µM -1.2254354216611 0.118350335903178 no 2963 0.110205603864682 993 13018434
SGTC_1819 st053448 58.6 µM -1.22940265318933 0.117532756009409 no 2964 0.109460437997106 993 2857616
SGTC_1614 st002383 48.6 µM -1.23469933585608 0.116447443174862 no 2965 0.108471211583437 959 1947235
SGTC_2098 5376439 882.5 nM -1.2352920099294 0.116326445418129 no 2966 0.108360923162489 980 2844116
SGTC_380 3970-0968 6 µM -1.23592581753146 0.11619714875218 no 2967 0.108243069674787 982 2891601
SGTC_1321 1326-2144 215 µM -1.23623684208516 0.116133737102124 no 2968 0.108185269904475 996 3513030
SGTC_2723 salbutamol 83.58 µM -1.23652109737002 0.116075804651932 no 2969 0.108132464279696 975 9884233 β2-adrenoceptor agonist
SGTC_3298 9116858 71.43 µM -1.23678473150052 0.116022093219317 no 2970 0.10808350599878 1004 2506942
SGTC_2081 5214970 32.255 µM -1.23966624847379 0.11543617816097 no 2971 0.107549432947088 990 2063512
SGTC_3340 9146634 11.102 µM -1.23992523781174 0.115383619572768 no 2972 0.107501524031294 971 4907387
SGTC_2961 9083290 32.55 µM -1.24134894687249 0.11509499965434 no 2973 0.107238435111081 984 17741490
SGTC_2732 terfenadine 20 µM -1.24292203300562 0.11477669481344 no 2974 0.106948282829549 1006 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2619 obliquin 87.91 µM -1.24371205421908 0.114617075070509 no 2975 0.106802778965528 962 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1498 4478-3555 97.6 µM -1.24406020473529 0.114546783212316 no 2976 0.106738702956348 980 3437919
SGTC_2348 9022543 33.42 µM -1.2460718084844 0.114141239644051 no 2977 0.106369016789801 962 3162678 YDL140C RPO21
SGTC_1241 0364-0022 50.8 µM -1.24646859088514 0.114061368374741 no 2978 0.106296206682175 1002 4563895
SGTC_2987 9018338 71.43 µM -1.25182132587677 0.112987766413943 no 2979 0.105317488738069 977 5055682
SGTC_2924 9010168 62.78 µM -1.25412934807508 0.112527077056863 no 2980 0.104897497335358 999 2993929
SGTC_416 estradiol valerate 100 µM -1.25547132562915 0.112259831291186 no 2981 0.104653855524396 988 13791 A steroid.
SGTC_2368 9071271 200 µM -1.25655010351051 0.1120453290639 no 2982 0.104458296133059 989 27209959
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.25661015521401 0.112033397108223 no 2983 0.104447417826608 1027 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_152 4469-0003 551.229 µM -1.25736064488999 0.111884355395312 no 2984 0.104311536592276 975 697280
SGTC_2560 caryophyllene 100 µM -1.25801760508948 0.111754004378466 no 2985 0.104192694703112 992 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_921 1561-0023 372 µM -1.25892964002661 0.111573222740836 no 2986 0.104027873403344 979 24050882
SGTC_860 0443-0016 25.1 µM -1.2593724029926 0.111485534691178 no 2987 0.103947926285795 982 5337942
SGTC_2913 7966556 36.57 µM -1.2611279563307 0.111138337401351 no 2988 0.103631374875167 949 2976516
SGTC_1840 st055363 71 µM -1.26164646886295 0.111035939002958 no 2989 0.103538013583713 1007 676033
SGTC_3280 9140961 49.47 µM -1.2633455449711 0.110700870644413 no 2990 0.103232512486232 1004 4901226
SGTC_3350 9150499 3.57 µM -1.26370398069929 0.110630277543466 no 2991 0.103168147910145 997 4910996 YPR165W RHO1
SGTC_308 4092-1169 104 µM -1.2677738417519 0.109830989884294 no 2992 0.10243936308423 990 2268590 YDL196W YDL196W
SGTC_1287 0971-0001 34.6 µM -1.26796595971376 0.109793362186401 no 2993 0.102405053525581 958 4665869
SGTC_2880 9042983 58.44 µM -1.26957189478662 0.109479190048283 no 2994 0.102118582985829 996 6464714
SGTC_1600 coumarin 106 71.1 µM -1.27278133559739 0.108853256612567 no 2995 0.101547823025635 985 100336 A hepatotoxic, DNA x-linker.
SGTC_2236 dapsone 200 µM -1.27672491949299 0.108087672528521 no 2996 0.100849690247863 984 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_983 1491-0821 12.2 µM -1.28269408792874 0.106936240324857 no 2997 0.0997996359934156 983 46495113
SGTC_3244 9134489 49.47 µM -1.28386334114331 0.106711735632937 no 2998 0.0995948880005344 1004 16584271
SGTC_1820 st053765 18.6 µM -1.28397434837259 0.106690439171342 no 2999 0.0995754654848567 981 3690829
SGTC_1147 3809-1045 12.3 µM -1.28557398564567 0.106383893247974 no 3000 0.0992958902636162 997 325925
SGTC_1132 3456-3614 2.5 µM -1.28756282540177 0.106003650257309 no 3001 0.0989490934162265 987 3125502
SGTC_2936 9038235 15.59 µM -1.28829092977101 0.105864691050416 no 3002 0.0988223546432265 969 4749415
SGTC_304 1310-0298 97 µM -1.28832325758967 0.105858524318601 no 3003 0.0988167301997744 999 1550234
SGTC_700 3453-2283 142 µM -1.29123569025404 0.10530402460014 no 3004 0.0983109813844116 982 565664
SGTC_3268 9137683 49.47 µM -1.29158347221659 0.105237950901608 no 3005 0.0982507153989581 1040 1953228
SGTC_230 MPP+ 141.667 µM -1.29374956410109 0.104827098974751 no 3006 0.097875969541665 1008 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1155 4088-0394 48.2 µM -1.29423663954293 0.10473487344718 no 3007 0.0977918472643961 982 2326248
SGTC_1209 2323-2347 50.3 µM -1.29498248696186 0.104593764522483 no 3008 0.0976631354936965 960 5412760
SGTC_482 fipronil 114 µM -1.29597483332493 0.104406233364458 no 3009 0.0974920777438572 999 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2419 paclitaxel 166.5 µM -1.29783235635222 0.104055858363717 no 3010 0.0971724742099458 986 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1943 st076331 65.2 µM -1.2991872801667 0.1038008243406 no 3011 0.096939832824074 1004 24208415
SGTC_2540 epiandrosterone 100 µM -1.30084112655827 0.103490139735551 no 3012 0.0966564207073022 988 441302 A steroid.
SGTC_338 4055-0136 114 µM -1.30601316519258 0.10252289904096 no 3013 0.0957740402740226 1009 2900563
SGTC_189 3970-0742 2.116 µM -1.30675247006902 0.102385177743084 no 3014 0.0956483961072687 988 2891807
SGTC_2389 9091542 195.52 µM -1.30725224927232 0.102292152693937 no 3015 0.0955635278365982 974 3626624 YOL127W RPL25
SGTC_472 calcifediol 10 µM -1.30930934275196 0.101909908391526 no 3016 0.0952147930864777 1009 5283731 A vitamin D metabolite.
SGTC_1855 st056195 39.6 µM -1.31020675883106 0.101743478709543 no 3017 0.0950629499447321 956 4028379
SGTC_1394 3474-0001 65.7 µM -1.31290269940027 0.101244695151722 no 3018 0.0946078685880398 980 5017666 YIL048W NEO1
SGTC_2337 9009472 200 µM -1.31504373009463 0.100849848193004 no 3019 0.0942476030281118 983 5742383
SGTC_2822 7994718 71.43 µM -1.31511563556756 0.10083660696535 no 3020 0.0942355212719293 1030 1018011
SGTC_919 tnp00227 403.569 nM -1.31584509899401 0.100702349607925 no 3021 0.0941130193870963 998 1269246 A methoxyflavone. YNL221C POP1
SGTC_1989 st071868 50.2 µM -1.31903257977398 0.100117224846847 no 3022 0.0935791103990336 981 16414057
SGTC_696 1560-0013 611 µM -1.32029082774962 0.0998869333046401 no 3023 0.0933689683877642 992 1650269
SGTC_1667 st014849 34.6 µM -1.32180849323703 0.0996096767957022 no 3024 0.0931159647150674 995 5348460
SGTC_1770 st043884 66.3 µM -1.32367195339289 0.0992700180632403 no 3025 0.092806008494536 1010 670149
SGTC_3000 9075062 71.4286 µM -1.32527213525167 0.0989790243679803 no 3026 0.092540453750228 955 17057871
SGTC_2728 chlorpromazine 9.18 µM -1.32540874841206 0.0989542101525278 no 3027 0.0925178084777621 1034 2726 A thorazine and dopamine antagonist.
SGTC_2173 5763948 167 µM -1.32555555365926 0.098927549734658 no 3028 0.0924934783146598 1003 2867177
SGTC_1057 3448-5381 134 µM -1.32888877826822 0.0983236363645295 no 3029 0.0919423333072457 945 5497911
SGTC_749 1000-0129 128 µM -1.33238698118775 0.0976927406912487 no 3030 0.0913665289529667 1006 708470
SGTC_2163 5671233 125 µM -1.33313599357433 0.0975580440646116 no 3031 0.091243589692669 967 701023
SGTC_508 roscovitine 141 µM -1.3395369866188 0.0964124903728893 no 3032 0.0901979609810242 1024 160355 A CDKinase inhibitor.
SGTC_1847 st056231 15 µM -1.34221605943321 0.0959359756035972 no 3033 0.0897629754235623 985 5393180
SGTC_391 gliotoxin 8.33 µM -1.34402125297083 0.0956158720375 no 3034 0.0894707572182336 994 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2132 5317594 122.667 µM -1.34426404536628 0.0955728792276319 no 3035 0.0894315089046775 1011 794577
SGTC_1791 st048313 56.1 µM -1.34519476976853 0.0954082016672149 no 3036 0.0892811724044726 969 1204976
SGTC_3115 9123671 49.47 µM -1.34986165069457 0.0945856165532796 no 3037 0.0885301824315303 1030 3286988
SGTC_3053 9095903 49.47 µM -1.35282187580229 0.0940665637309554 no 3038 0.0880562711747363 1037 17174018
SGTC_153 4077-0274 519.67 µM -1.35392384133226 0.0938738802656231 no 3039 0.0878803381869323 973 3121976
SGTC_17 0960-0276 49.807 µM -1.35935557006488 0.0929283744263577 no 3040 0.0870169714267042 1007 6821114
SGTC_1224 0823-0416 294 µM -1.36137861239049 0.0925780270442369 no 3041 0.0866970357198427 992 3598164
SGTC_1203 3992-3522 103 µM -1.36300006784697 0.0922979320136418 no 3042 0.0864412446146171 1017 5322312
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.36529451326189 0.0919026550855356 no 3043 0.0860802513919098 985 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1683 st010134 710 nM -1.3695993821124 0.0911644164941635 no 3044 0.0854059963005908 1017 3818134
SGTC_1674 st016616 23.6 µM -1.3698451377565 0.0911224051279474 no 3045 0.0853676242379299 996 625830
SGTC_2070 5230947 200 µM -1.37124199284042 0.0908838886444744 no 3046 0.0851497658345187 1018 2835538
SGTC_1951 sophoraflavanone G 9.2 µM -1.37199947542986 0.0907547404623146 no 3047 0.085031800557147 989 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3285 9112818 20.8695 µM -1.3729422703328 0.0905941874738762 no 3048 0.084885147137173 993 17017947 YPR165W RHO1
SGTC_115 0527-0192 112.043 µM -1.37530321413139 0.0901930564521471 no 3049 0.0845187302392726 1014 4233931
SGTC_2112 5488546 200 µM -1.37572914539514 0.0901208302229558 no 3050 0.0844527525216215 1023 600757
SGTC_1481 3346-2004 36 µM -1.37713539026436 0.0898826748895267 no 3051 0.0842351963964653 1023 2770522
SGTC_1562 morin hydrate 59.1 µM -1.38444032030475 0.0886530663796656 no 3052 0.0831118350419717 999 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_499 genistein 192 µM -1.38547794528493 0.0884794284040054 no 3053 0.0829531858672867 1028 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.38595189693796 0.0884002008591804 no 3054 0.0828807961782391 1009 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_989 1501-0895 10.3 µM -1.39352906074595 0.0871407425331828 no 3055 0.0817299317262073 987 2830112
SGTC_2437 5741531 144.16 µM -1.3944315475011 0.0869916308986269 no 3056 0.0815936635307837 982 2262990
SGTC_647 0140-0236 81 µM -1.39892294766362 0.0862523814690673 no 3057 0.0809180451634504 1027 990837
SGTC_3184 9108758 49.47 µM -1.39900886046512 0.0862382868320321 no 3058 0.0809051630278739 1015 902885
SGTC_993 3909-8757 62.7 µM -1.40007969358776 0.0860627531822476 no 3059 0.0807447275804863 1007 4288324 YLR208W SEC13
SGTC_2155 5570423 76 µM -1.40179508717027 0.0857821188675221 no 3060 0.0804882229732507 1013 797402
SGTC_823 0417-1665 178 µM -1.40317696526691 0.0855565455024092 no 3061 0.0802820373577173 1022 3429856
SGTC_1179 1021-1431 9.29 µM -1.40415315881883 0.0853974627104018 no 3062 0.0801366233964409 1017 2840958
SGTC_2308 7584454 197.62 µM -1.40584145134318 0.0851228577051612 no 3063 0.0798856051013241 996 893577
SGTC_850 0388-0143 75.9 µM -1.40733161540398 0.0848810290620882 no 3064 0.0796645393399144 1017 67273
SGTC_1214 0358-0031 63.7 µM -1.4074411021433 0.0848632815326119 no 3065 0.0796483152572006 1027 4301366
SGTC_555 4296-0685 37 µM -1.41293381661392 0.0839764927689497 no 3066 0.0788375924326822 1027 2908540 YHR072W ERG7
SGTC_2587 piperic acid 92.2 µM -1.41616402090218 0.0834582415811133 no 3067 0.0783637436525463 997 5370536
SGTC_180 1486-1293 102.781 µM -1.41680147375377 0.0833562537860319 no 3068 0.0782704893578585 992 4140536
SGTC_2113 5491891 107.031 µM -1.41854205459278 0.083078250755071 no 3069 0.0780162848401582 996 789979
SGTC_2649 anisomycin 9.56 µM -1.41859430484638 0.0830699162140651 no 3070 0.0780086636056069 1018 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_536 3852-0578 10.6 µM -1.41875809111642 0.0830437944181449 no 3071 0.0779847773614015 1023 2869208
SGTC_1966 st070145 16.1 µM -1.42131900786635 0.082636164343646 no 3072 0.0776120200447266 1001 3748532
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.42387569360117 0.0822307117876555 no 3073 0.0772412295501895 995 5379071
SGTC_1986 st071812 45 µM -1.42506494438422 0.0820426255451367 no 3074 0.0770692144136038 1026 11838594
SGTC_1748 st037455 53.6035 µM -1.4268088405819 0.0817674056062699 no 3075 0.0768175011315646 1027 580690
SGTC_2315 7733312 200 µM -1.42735127857596 0.0816819406461283 no 3076 0.0767393334319748 1003 726316
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.42742461099455 0.0816703917720118 no 3077 0.0767287705508129 1008 165506
SGTC_640 3381-0960 37.1 µM -1.4275467419251 0.0816511605180208 no 3078 0.0767111811330154 1019 1745025
SGTC_296 1222-0039 74.9 µM -1.42850486734237 0.0815004084658449 no 3079 0.076573297327381 1023 5984176
SGTC_1102 cgs 12066b 26.1 µM -1.43049872162256 0.0811873672112637 no 3080 0.0762869662317855 1013 6438352 A 5-HT1B full agonist.
SGTC_1055 3448-0672 86 µM -1.43193830141705 0.0809619133515915 no 3081 0.0760807397720531 1009 748378
SGTC_586 0957-0265 8.15 µM -1.4321644985674 0.0809265314197987 no 3082 0.0760483746025706 975 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_856 0433-0016 11.3 µM -1.43357060470873 0.0807068489754281 no 3083 0.0758474185169875 1009 3911780
SGTC_1814 st052110 31.539 µM -1.43478134590967 0.0805180503857862 no 3084 0.0756747076027056 1012 674163
SGTC_1960 st011366 51.8 µM -1.43552223504155 0.0804026834827568 no 3085 0.0755691684336489 1005 3972846
SGTC_3055 9094636 49.47 µM -1.43561709546625 0.0803879213984287 no 3086 0.0755556637314914 1011 25236176
SGTC_2593 nobiletin 86.24 µM -1.4375816697104 0.0800826565238687 no 3087 0.0752763924691219 997 72344 An anti-infammatory.
SGTC_1993 st073995 70.8 µM -1.4400723817967 0.0796968986831163 no 3088 0.0749234609414846 1009 3098394
SGTC_3175 9106517 49.47 µM -1.44170664927058 0.0794445505581555 no 3089 0.0746925735189715 1024 41468073
SGTC_836 0330-0104 1.35 µM -1.44251280518797 0.0793202945248163 no 3090 0.0745788809055621 986 46494820
SGTC_2457 5731572 11.68 µM -1.44376093341228 0.0791282058222376 no 3091 0.0744031173227081 1006 2865357
SGTC_2465 5809242 33.21 µM -1.44628966304686 0.0787401108327454 no 3092 0.0740479869264838 1048 2731748
SGTC_392 N-ethylmaleimide 8.33 µM -1.45481280887379 0.0774426476491848 no 3093 0.0728605455769597 997 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_6 0844-0013 19.835 µM -1.45560008763485 0.0773236256367445 no 3094 0.072751601904195 1039 1584900
SGTC_514 4466-0038 2.65 nM -1.45635443733388 0.0772097122977641 no 3095 0.0726473320123843 966 5722064
SGTC_2984 9022109 38.96 µM -1.46177073359077 0.0763955459498152 no 3096 0.0719020232744173 1035 6459207
SGTC_885 0865-0106 16.8 µM -1.46744045219391 0.0755503006571596 no 3097 0.0711281384974418 1023 2793380
SGTC_2270 7924575 90.91 µM -1.46798442291642 0.0754695812728341 no 3098 0.0710542271026693 1005 1262135
SGTC_1694 st024011 44.9 µM -1.47062416549232 0.0750788050262706 no 3099 0.07069639248028 1026 2787533
SGTC_2193 5925765 200 µM -1.47068524690407 0.0750697810945034 no 3100 0.0706881289125099 1015 877370
SGTC_662 k832-1615 104 µM -1.47428069762246 0.0745400591149609 no 3101 0.0702030150263447 1019 5878478
SGTC_2689 tacrolimus 100 µM -1.47532457591515 0.0743867989957122 no 3102 0.0700626511320746 988 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2496 diffractaic acid 79.83 µM -1.4759062122342 0.0743015087564289 no 3103 0.069984535791573 1015 94870 An apoptosis inducer which activates caspases.
SGTC_3067 9117431 49.47 µM -1.4760090055051 0.0742864430803025 no 3104 0.0699707373462443 1038 17150885
SGTC_3192 9110362 49.47 µM -1.47729999504875 0.0740974305291233 no 3105 0.0697976196681294 1037 16649480
SGTC_371 0195-0006 7.36 µM -1.48359314600851 0.0731813128258978 no 3106 0.0689584444041074 982 3928593
SGTC_2776 terbinafine 19.92 µM -1.48423445257925 0.0730884441328501 no 3107 0.0688733663586059 979 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_896 0964-0007 44.5 µM -1.48581465370881 0.0728599974381503 no 3108 0.0686640765269617 996 6756758
SGTC_2727 riluzole 51.77 µM -1.4863704167747 0.0727797818870294 no 3109 0.0685905851533406 1026 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_313 3474-0040 5.03 µM -1.49019251124719 0.0722299538245229 no 3110 0.0680868124449951 1024 1043375 YIL048W NEO1
SGTC_3229 9132204 49.47 µM -1.49063618482032 0.0721663358566259 no 3111 0.0680285193813815 1044 17682924
SGTC_3001 9076041 71.4286 µM -1.49419350833313 0.0716578060227945 no 3112 0.0675625244320999 1022 16004211
SGTC_2293 7624732 200 µM -1.49701524969733 0.071256388598471 no 3113 0.0671946450471145 1006 894453
SGTC_2464 5717415 7.67 µM -1.50075589942847 0.0707269123585285 no 3114 0.0667093544838677 1017 5285744
SGTC_335 4077-0256 27.6 µM -1.50188237072345 0.0705680579189689 no 3115 0.066563745150228 996 3121989
SGTC_1460 k062-0059 9.15 µM -1.50565505583987 0.0700380325196796 no 3116 0.0660778735933598 1013 1373085
SGTC_2240 6690706 185.951 µM -1.5062695038869 0.0699519993597436 no 3117 0.065999001720532 1017 805876
SGTC_1485 3909-9022 254 µM -1.50924537346642 0.0695364772777105 no 3118 0.0656180444337687 1047 714516
SGTC_2152 5568786 200 µM -1.5096416618364 0.0694812870455047 no 3119 0.0655674422991308 1028 5399883
SGTC_1716 st033144 30.6155 µM -1.51819551386591 0.0682982154685326 no 3120 0.0644825590557082 1028 674617
SGTC_1713 st033146 12.748 µM -1.52009822390799 0.0680371800505854 no 3121 0.0642431454686153 1034 674619
SGTC_337 1315-0038 354 µM -1.52164673245374 0.0678253070996676 no 3122 0.0640488106445489 1023 1626437
SGTC_949 1165-0505 146 µM -1.52276468984073 0.0676726608437645 no 3123 0.0639087934883393 1020 6244267
SGTC_3249 9135183 49.47 µM -1.5238750412786 0.06752131594195 no 3124 0.0637699646656028 979 4902779
SGTC_3135 9127742 49.47 µM -1.52892181661309 0.0668367163510258 no 3125 0.0631419135440651 1008 3643468
SGTC_118 0083-0097 135.343 µM -1.52957014817236 0.0667491602451303 no 3126 0.0630615816214427 1042 5207356
SGTC_2757 clomiphene 4.22 µM -1.52986490165812 0.0667093836332391 no 3127 0.0630250863397284 1034 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_701 4424-0219 185 µM -1.53218212240607 0.0663973162590734 no 3128 0.0627387494472351 1034 2911779
SGTC_1328 1441-0025 69.2 µM -1.54007124889512 0.0653433331328499 no 3129 0.0617714935483475 1019 4562601
SGTC_1947 st076332 61.6 µM -1.55071976725302 0.0639413350778079 no 3130 0.0604844276264777 1029 24208416
SGTC_628 1636-0253 16 µM -1.55459150153127 0.0634374160725092 no 3131 0.0600216945366564 1010 4456143
SGTC_1136 pergolide 1.05886 µM -1.56041064591476 0.0626858561575132 no 3132 0.0593314353237228 1021 47811 A dopamine receptor agonist.
SGTC_947 3447-0010 211 µM -1.56262981134685 0.0624010789444516 no 3133 0.0590698460745199 1024 748350
SGTC_1182 1222-0449 220 µM -1.56282240058257 0.0623764123376855 no 3134 0.0590471869042963 1027 658318
SGTC_2966 9084041 48.03 µM -1.56325126401365 0.0623215113232208 no 3135 0.0589967532884375 1029 17741380
SGTC_2872 9044037 25.97 µM -1.56367234772995 0.0622676429030816 no 3136 0.0589472674402623 1045 6465195
SGTC_1299 1079-1439 3.74 µM -1.56450900314612 0.062160718974383 no 3137 0.0588490401594909 1032 323161
SGTC_2694 st077685 81.9 µM -1.56529393144249 0.0620605360062313 no 3138 0.0587570027081298 1025 2838096
SGTC_918 glabranin 770.725 nM -1.56620621502744 0.0619442566143296 no 3139 0.0586501740995381 1045 124049 Also referred to as licorice root.
SGTC_1211 1056-0033 32.3 µM -1.5700042511542 0.0614619865728946 no 3140 0.0582070611351999 1007 6741922
SGTC_344 k064-0035 6.43 µM -1.57220789072676 0.0611835184698914 no 3141 0.057951173033957 996 5088750
SGTC_1247 0448-0043 5.84 µM -1.57255766877266 0.0611394087541008 no 3142 0.0579106380067337 1034 3089013 YGL099W LSG1
SGTC_295 k015-0027 31 µM -1.57582376119035 0.0607287278486065 no 3143 0.0575332123965223 1037 3887424
SGTC_726 3448-4391 34.2 µM -1.57762028379896 0.0605037532693829 no 3144 0.0573264348233501 1036 1356692
SGTC_51 1013-0126 23.419 µM -1.58395356496609 0.0597158485221978 no 3145 0.0566021432373802 1028 1627850
SGTC_1681 tripelennamine 100 µM -1.58524004139413 0.0595567885079853 no 3146 0.0564559030534154 1012 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_984 1492-0255 2.91 µM -1.59552509828535 0.0582970549532677 no 3147 0.0552974310449812 1037 1585198
SGTC_854 0422-0053 192 µM -1.59926977227164 0.057843632352072 no 3148 0.0548803364972003 1037 3596728
SGTC_1886 st057356 49.9 µM -1.60117952869693 0.0576134600498518 no 3149 0.0546685808028884 1034 24207747
SGTC_2687 chenodiol 100 µM -1.60890961511948 0.0566891466643186 no 3150 0.0538180533636302 1014 5702181 A cholesterol synthesis inhibitor.
SGTC_1511 0906-3109 28.5 µM -1.61075719091126 0.056469964608706 no 3151 0.0536163275178668 1026 2882180
SGTC_300 r073-0011 5.04 µM -1.61392134576778 0.0560961457106526 no 3152 0.0532722439881119 1048 2735780
SGTC_121 0557-0495 61.343 µM -1.61821277995694 0.055592269448351 no 3153 0.052808374798492 1045 3104427
SGTC_1463 k081-0032 34.1 µM -1.62001152203406 0.0553821366158301 no 3154 0.0526149009293459 968 977755
SGTC_3191 9110352 49.47 µM -1.62047601745341 0.0553279753031381 no 3155 0.052565030998072 1017 17122424
SGTC_2047 4141938 200 µM -1.62417127122978 0.05489858829951 no 3156 0.0521696302099989 1047 3807862
SGTC_2482 5981709 142.65 µM -1.62678528387533 0.0545964347255502 no 3157 0.051891354092065 1027 877755
SGTC_2517 totarol 10 µM -1.65220693763249 0.05172607386155 no 3158 0.0492461863308251 1027 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_117 lucigenin 22.078 µM -1.6523399610189 0.0517113759678961 no 3159 0.0492326336734711 1054 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1228 0124-0032 52.5 µM -1.65244866262681 0.0516993678781309 no 3160 0.0492215611732915 1033 X1228
SGTC_2897 9048598 12.99 µM -1.65253448514467 0.0516898887702193 no 3161 0.0492128205746274 1053 6467404
SGTC_2718 lomofungin 53.02 µM -1.65513242699626 0.0514035991404744 no 3162 0.0489488192238961 1041 5351222 A RNA synthesis inhibitor.
SGTC_883 0850-0245 24.6 µM -1.65670805852498 0.0512305820215958 no 3163 0.0487892564896072 1025 6823229 YPR165W RHO1
SGTC_2303 7774051 200 µM -1.65835946471567 0.0510497418487508 no 3164 0.048622466575581 1045 2953184
SGTC_1080 nisoldipine 24.4 µM -1.65850736516539 0.0510335705663623 no 3165 0.0486075510868843 1043 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3239 9133757 49.47 µM -1.66241189346863 0.0506081261958253 no 3166 0.048215107909943 1069 17036923
SGTC_632 0781-2353 4.65 µM -1.66643043628953 0.0501732135292991 no 3167 0.0478138564213009 1054 6811515 YHR007C ERG11
SGTC_1070 indatraline 8.81 µM -1.67302483911617 0.049465986154066 no 3168 0.0471612031396132 1038 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1323 1348-1351 11.2 µM -1.67439062188471 0.049320509998037 no 3169 0.0470269273490677 1036 6989654
SGTC_1991 st073000 8.92 µM -1.67558011971947 0.049194089293275 no 3170 0.0469102327699834 1049 4301969 YIL048W NEO1
SGTC_91 0417-1751 58.384 µM -1.68013909568593 0.0487119529273515 no 3171 0.0464651279006894 1056 6795624
SGTC_667 1498-1044 59 µM -1.68197406644704 0.0485189640768024 no 3172 0.0462869344191409 1057 6739982
SGTC_1259 0671-0132 43 µM -1.68472449211261 0.0482308398491265 no 3173 0.0460208694263047 1033 X1259
SGTC_50 0929-0078 56.389 µM -1.68620561172019 0.0480762513257199 no 3174 0.0458781017044667 1007 1377751
SGTC_3256 9138902 49.47 µM -1.68730117637337 0.047962159557441 no 3175 0.0457727274620123 1065 17228773
SGTC_345 1362-0200 395 µM -1.6878932270978 0.0479005938405775 no 3176 0.0457158635075864 1048 1419823
SGTC_3332 9141069 11.198 µM -1.68876907033246 0.0478096333622086 no 3177 0.0456318466376602 1036 17332883
SGTC_1108 betulinic acid 729.144 nM -1.69126333079426 0.0475513501371875 no 3178 0.0453932600906575 1045 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2006 4011487 200 µM -1.69628974209199 0.0470342563135629 no 3179 0.0449155110833711 1039 45595294
SGTC_580 1123-0028 41 µM -1.70004036538645 0.0466513547568831 no 3180 0.0445616665614416 1056 1677248 YPR107C YTH1
SGTC_1817 st052116 64.4 µM -1.70110172322431 0.0465434558510774 no 3181 0.0444619436989341 1055 4361398
SGTC_2731 amoxapine 43.43 µM -1.70713261500222 0.045934145204028 no 3182 0.0438987031169939 1076 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_433 pimozide 108 µM -1.70759139501518 0.0458880574756805 no 3183 0.0438560930816881 1048 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2018 5133068 143 µM -1.7164263015739 0.0450077540076753 no 3184 0.0430420230412948 1042 785362
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.71905565866 0.0447484075628612 no 3185 0.0428021188519323 1023 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_903 1134-0042 114 µM -1.72061480859354 0.0445951901698248 no 3186 0.0426603722334216 1037 701009
SGTC_2191 5911152 200 µM -1.72374827436368 0.0442885431373866 no 3187 0.0423766480486374 1046 2875902
SGTC_1643 st009866 20.2 µM -1.72703973221059 0.0439682671768668 no 3188 0.0420802640263369 1021 3156273 YOR207C RET1
SGTC_733 4069-0007 56.1 µM -1.74187145541383 0.0425481634386826 no 3189 0.0407654698708654 1046 5717425 YNL287W SEC21
SGTC_3235 9132602 49.47 µM -1.74257091629451 0.0424821183602377 no 3190 0.0407042969852458 1046 4912240
SGTC_3204 9114183 49.47 µM -1.74342135229894 0.042401929496029 no 3191 0.0406300206104669 1021 17027248
SGTC_370 0180-0345 38.7 µM -1.75047840449316 0.0417412230561943 no 3192 0.0400178986816541 1017 3989527
SGTC_787 4152-0075 138 µM -1.75116569139759 0.0416773248297405 no 3193 0.0399586866706461 1028 9566539
SGTC_2584 androsterone 48.74 µM -1.76536726033366 0.040374623188533 no 3194 0.0387510310345993 996 2754130 A steroid.
SGTC_3210 9128157 49.47 µM -1.76916349835468 0.0400320542436931 no 3195 0.0384332968479774 1023 17590849
SGTC_1963 st076565 50.3 µM -1.76929237571223 0.0400204660527932 no 3196 0.0384225475660252 1068 4914280
SGTC_1084 voriconazole 435 nM -1.77201149772144 0.0397766071445756 no 3197 0.0381963243257555 1050 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_137 0438-0332 85.389 µM -1.77697472582769 0.0393346057668346 no 3198 0.0377861991555144 1038 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1696 st025591 34.7925 µM -1.77803847807417 0.0392403950605887 no 3199 0.0376987677542484 1033 2787147
SGTC_2405 ticlatone 3.52 µM -1.78198329470094 0.0388926262884231 no 3200 0.0373759779841536 1035 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_610 4215-0184 155 µM -1.78301061494945 0.0388024724964558 no 3201 0.037292287702958 1015 5605015
SGTC_2009 4012297 12.05 µM -1.78806651380343 0.0383612628537508 no 3202 0.0368826386825057 1024 45595307
SGTC_1610 st001799 48.1 µM -1.7886491050848 0.0383106861030292 no 3203 0.0368356721370263 1053 621897
SGTC_2766 oltipraz 83.91 µM -1.79368674497385 0.0378756151616935 no 3204 0.0364315910737811 987 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_35 0133-0054 64.071 µM -1.79403532615498 0.0378456600336415 no 3205 0.0364037652662626 1037 99677
SGTC_1144 3486-0183 12.5 µM -1.80146758070419 0.0372115609721744 no 3206 0.0358146063289287 1044 6744069
SGTC_2485 5633444 17.78 µM -1.80462587611597 0.0369447452374014 no 3207 0.0355666230341055 1043 5724239
SGTC_2846 9008642 19.48 µM -1.80609187631872 0.0368214287415998 no 3208 0.0354519947760366 1064 2992898
SGTC_664 1222-0054 14.9 µM -1.8087093818126 0.0366020874108244 no 3209 0.035248082345717 1055 6813991
SGTC_402 epigallocatechin gallate 10 µM -1.81547147324632 0.0360403828999515 no 3210 0.0347257430002151 1034 65064 An antioxidant.
SGTC_1686 st019653 115.5 µM -1.81782052263111 0.0358469151433385 no 3211 0.0345457844292801 1074 97252
SGTC_888 0916-0002 6.97 µM -1.82211561515693 0.0354953717951723 no 3212 0.0342187224359027 1061 2802138 YIL048W NEO1
SGTC_5 0352-0601 109.883 µM -1.83035038336581 0.0348292803284256 no 3213 0.033598780962433 1037 762456
SGTC_2305 7443522 69.23 µM -1.83169048783284 0.0347218594945954 no 3214 0.033498773323198 1035 5415886
SGTC_2618 avocadyne 43.43 µM -1.83994048690948 0.0340665295597311 no 3215 0.0328884875646457 1065 3015189
SGTC_248 streptozotocin 5.23457 mM -1.84254472430637 0.0338617890557645 no 3216 0.032697755404445 1063 5300 DNA alkylating agent.
SGTC_3337 9144342 33.5465 µM -1.84605348980812 0.033587537872222 no 3217 0.0324422195714869 1049 17682949
SGTC_1581 himbacine 57.9 µM -1.85991383454446 0.0325220071512676 no 3218 0.031448858847445 1070 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_552 k242-0005 476 µM -1.86194026732883 0.0323685847077289 no 3219 0.0313057551648057 1066 4088318
SGTC_992 3909-8734 162 µM -1.86559247939605 0.0320935817929054 no 3220 0.0310492013099153 1068 4288319
SGTC_12 0849-0099 9.267 µM -1.87281627609033 0.031555327159555 no 3221 0.0305468798174047 1065 6071388
SGTC_1699 st031318 29.054 µM -1.88023199352319 0.0310105556580566 no 3222 0.0300382335423592 1052 5340658
SGTC_1704 st028805 70.8 µM -1.88349259315101 0.0307735016440931 no 3223 0.0298168213386476 1056 2876101
SGTC_1487 3970-0795 2.82 µM -1.88512323750282 0.0306555135048117 no 3224 0.0297066007054766 1055 3765103
SGTC_999 SEC7.066 22.7 µM -1.88731129099752 0.0304977818662072 no 3225 0.0295592343345354 1069 740511 YDR170C SEC7
SGTC_2447 5741742 33.78 µM -1.89220550767123 0.0301474020611445 no 3226 0.029231802417872 1057 1776504
SGTC_148 3253-0744 288.01 µM -1.89454254465232 0.0299812731409659 no 3227 0.0290765164125674 1043 6893655
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.90262738631427 0.0294124056449607 no 3228 0.0285445915132971 1070 61125 An anti-inflammatory.
SGTC_2044 5102272 200 µM -1.92027557303867 0.0282017325233859 no 3229 0.0274115500619937 1068 592666
SGTC_1743 st037606 46.3785 µM -1.92092377991729 0.0281580670939009 no 3230 0.0273706586584867 1044 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1362 1611-0397 101 µM -1.92886377596405 0.0276277543812894 no 3231 0.0268738879338426 1062 27816
SGTC_130 0136-0219 337.655 µM -1.93269577760442 0.0273748084536263 no 3232 0.0266368428311403 1054 234244
SGTC_1731 st035964 63 µM -1.93443501538726 0.0272606422413432 no 3233 0.0265298323824391 1052 6739575
SGTC_3356 9151811 4.48 µM -1.93729895887898 0.0270735142285428 no 3234 0.026354404732437 1065 1859254 YPR165W RHO1
SGTC_375 3970-0961 9.27 µM -1.93812653328118 0.0270196411668371 no 3235 0.0263038935261936 1053 2898222
SGTC_741 4582-0002 126 µM -1.94032467776151 0.0268769816415926 no 3236 0.0261701220538927 1064 2912688
SGTC_539 4859-0462 2.54 µM -1.94901817715686 0.0263189209956994 no 3237 0.0256466270034111 1043 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2838 9002687 71.43 µM -1.95048821823747 0.0262255189524534 no 3238 0.0255589781457376 1058 6457060
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.95074734889146 0.0262090833259394 no 3239 0.0255435539258202 1056 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.96095442936659 0.0255685064999662 no 3240 0.0249421695418848 1069 6710655
SGTC_1958 st076513 41.9 µM -1.97961842209732 0.0244310829407796 no 3241 0.0238732106870387 1068 732122 YGL099W LSG1
SGTC_2072 5231554 129 µM -1.97968237064102 0.0244272600194963 no 3242 0.0238696153692789 1068 789545
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.97977668871853 0.0244216224872919 no 3243 0.0238643134449484 1057 5377381
SGTC_1438 4092-1045 4 µM -1.98090112285791 0.024354497469088 no 3244 0.0238011815738527 1065 1351342
SGTC_1827 berberine 7.24 µM -1.98111259921102 0.0243418903490214 no 3245 0.0237893238368386 1018 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_349 k015-0014 24 µM -1.98511123962411 0.0241045416342386 no 3246 0.0235660482857556 1055 2196908
SGTC_486 niguldipine 82 µM -1.98851611703797 0.0239039725901801 no 3247 0.0233773191561331 1073 1236 A calcium channel blocker.
SGTC_3051 9093778 49.47 µM -1.9939945658825 0.0235842018489643 no 3248 0.0230763241903387 1084 17217378
SGTC_1531 st059297 52.4 µM -1.99794592114377 0.0233558056827111 no 3249 0.0228612616858046 1063 7566702
SGTC_256 clotrimazole 625 nM -2.00028964177792 0.0232212155352622 no 3250 0.0227344984374206 1049 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1619 st003326 88.7 µM -2.00281166727811 0.0230771159729079 no 3251 0.0225987535386802 1023 2849032
SGTC_1706 st031321 9.9705 µM -2.01136334663955 0.0225940969418002 no 3252 0.022143545963743 1068 6103185
SGTC_297 0986-0032 24 µM -2.01810016906962 0.0222196127058482 no 3253 0.0217904150435691 1056 2847425
SGTC_1655 st012546 55.1 µM -2.02430655096989 0.0218792627530056 no 3254 0.0214693100065857 1078 720985 YLR208W SEC13
SGTC_626 0214-0009 33 µM -2.02603442739119 0.0217852954338735 no 3255 0.0213806283975543 1065 3437874
SGTC_2470 5664817 21.68 µM -2.02666835299457 0.0217509061589676 no 3256 0.0213481705209799 1080 2859561
SGTC_1925 st057770 10.1 µM -2.02882860990667 0.0216340604748087 no 3257 0.0212378750842187 1058 5989122
SGTC_49 0717-0965 32.132 µM -2.03982298352931 0.0210475750924886 no 3258 0.0206839798936735 1072 5889349 YGL099W LSG1
SGTC_214 4373-3496 70 µM -2.0460659575619 0.0207205780224358 no 3259 0.0203749408816862 1070 3779166
SGTC_3046 9092212 49.47 µM -2.04764024510615 0.0206388018956976 no 3260 0.02029763144066 1077 25236637
SGTC_47 0149-0135 24.25 µM -2.05667017513184 0.0201750063958536 no 3261 0.0198589814657918 1074 5239155
SGTC_1896 st058441 89 µM -2.06764673553013 0.0196231574449953 no 3262 0.019336626978026 1062 688759
SGTC_1838 st055369 84.5 µM -2.08274308893496 0.0188851610479302 no 3263 0.0186373237862756 1068 676036
SGTC_3228 9131799 49.47 µM -2.08824559720657 0.0186221030434223 no 3264 0.0183878430553904 1079 17015818
SGTC_37 0566-0070 1.56 µM -2.08988132179685 0.0185445080829129 no 3265 0.0183142309172461 1075 1626686
SGTC_2462 5162487 171.77 µM -2.10192969842383 0.0179813991058686 no 3266 0.0177797172798962 1075 2259986
SGTC_441 propafenone 146 µM -2.1029572919946 0.0179340541544497 no 3267 0.0177347514754061 1070 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1930 st074634 34.3 µM -2.10861652577711 0.0176752134417091 no 3268 0.017488847630574 1059 684253 YOR116C RPO31
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.11193740192234 0.0175248133544288 no 3269 0.0173459094050211 1070 16725076
SGTC_3241 9133421 49.47 µM -2.11668967682526 0.0173114874640568 no 3270 0.017143096770475 1088 17018221
SGTC_2864 9034755 47.6 µM -2.11845695799576 0.017232723378575 no 3271 0.0170681932324804 1063 4930451
SGTC_136 0097-0015 404.482 µM -2.13647204881815 0.0164471455346545 no 3272 0.0163204784445094 1063 4861337
SGTC_1233 0325-0408 14.2 µM -2.13749305053546 0.0164035562929062 no 3273 0.0162789551778281 1074 12874
SGTC_191 3914-0123 66.505 µM -2.1434059646643 0.0161530588921575 no 3274 0.0160402572838951 1077 3144412
SGTC_1262 0737-0114 49.6 µM -2.1446882240814 0.0160991712380682 no 3275 0.0159888915285396 1072 765919
SGTC_3196 9111891 49.47 µM -2.15252848908862 0.0157730193617846 no 3276 0.0156778769743142 1073 18891510
SGTC_990 3985-0011 41.3 µM -2.1667719420579 0.0151949851695919 no 3277 0.0151261239359211 1050 5399565 YGL099W LSG1
SGTC_1637 st007924 17.4 µM -2.16761874408758 0.0151612005390441 no 3278 0.0150938532040356 1054 683336
SGTC_3222 9128301 49.47 µM -2.17298477068556 0.0149486103270553 no 3279 0.0148907317599636 1034 4911358
SGTC_1605 st000082 49.1 µM -2.18156281982462 0.0146140898041167 no 3280 0.0145709067063624 1057 1114022
SGTC_2165 5727197 32.143 µM -2.1970630436006 0.0140259428886669 no 3281 0.0140079720145991 1079 1361712
SGTC_1178 0988-0033 191 µM -2.21135871050391 0.0135017022292282 no 3282 0.0135055033474722 1070 5392207
SGTC_1227 3909-8010 46.6 µM -2.21960473488042 0.0132070703712546 no 3283 0.0132228052944645 1064 15982272
SGTC_2243 6634756 200 µM -2.23911964963755 0.0125318415189753 no 3284 0.0125740660335244 1066 885676
SGTC_1476 4112-3294 3.34 µM -2.25021136872178 0.0121615448096908 no 3285 0.0122177654804807 1035 704369
SGTC_2250 alverine citrate 130 µM -2.25479200521928 0.0120114097366359 no 3286 0.0120731936697593 1051 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2449 5812982 45.77 µM -2.26313617408364 0.0117420484807723 no 3287 0.011813648117801 1074 776185
SGTC_104 0074-0074 590.992 µM -2.26793735345869 0.0115894483204063 no 3288 0.0116665126235362 1073 3943124
SGTC_1959 st077091 55.8 µM -2.27206714676477 0.0114595680308967 no 3289 0.011541227522565 1071 821356 YKL052C ASK1
SGTC_2713 st079149 53.4 µM -2.27282335180377 0.0114359231492841 no 3290 0.0115184136130697 1074 3103253
SGTC_2051 5263410 176 µM -2.27705719886527 0.0113043213951671 no 3291 0.011391405078353 1072 227584
SGTC_1701 st028638 40.4 µM -2.27874529805958 0.011252217941972 no 3292 0.0113411051650693 1080 3490878
SGTC_1149 3909-7961 23.3 µM -2.28141351470901 0.0111702887351683 no 3293 0.0112619945337493 1074 735261
SGTC_460 trequinsin 123 µM -2.29483465199229 0.0107660039043012 no 3294 0.0108713009822456 1087 5537 A vasodilator.
SGTC_448 monastrol 171 µM -2.29625976060891 0.0107238328969452 no 3295 0.0108305167047392 1078 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_804 1595-0054 20.9 µM -2.30298533306995 0.0105267490371498 no 3296 0.0106398341658547 1075 761523 Stimulates phospholipase C.
SGTC_2136 5328288 199.296 µM -2.30718547971777 0.010405276670026 no 3297 0.0105222411091846 1079 262395
SGTC_2259 7964009 200 µM -2.31978498322921 0.010048187416514 no 3298 0.0101762559145091 1079 313134
SGTC_1130 3454-2858 15.9 µM -2.32371072787959 0.00993913319655804 no 3299 0.010070501552455 1068 715628 YIL048W NEO1
SGTC_3223 9129970 49.47 µM -2.32603335311602 0.00987510013116676 no 3300 0.0100083857237565 1081 17248386
SGTC_566 0958-0068 16.5 µM -2.33204212734096 0.00971111144448411 no 3301 0.00984923753452291 1067 6815365
SGTC_1933 st074711 15.9 µM -2.3414469125298 0.00945921620128357 no 3302 0.00960457879720323 1076 17250958
SGTC_1649 st011737 51.3 µM -2.34147561420773 0.00945845629218941 no 3303 0.00960384034830151 1053 1761035
SGTC_1049 3226-0134 66 µM -2.34769487418366 0.00929504832392876 no 3304 0.00944499438720661 1079 5702385
SGTC_2492 derrusnin 100 µM -2.35546157346415 0.0090944546836081 no 3305 0.00924985515190878 1082 1715307 Part of coumarin class of compounds.
SGTC_2244 6635614 200 µM -2.44057398881886 0.00713267034002964 no 3306 0.00733197087415784 1087 836499
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -2.45354930532349 0.00686897893046075 no 3307 0.00707270729964205 1076 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3307 9126885 69.2785 µM -2.47094772793359 0.0065289270535258 no 3308 0.00673777572151277 1085 24824909
SGTC_2792 7535235 81.82 µM -2.47103794482321 0.00652720328078877 no 3309 0.00673607615143151 1076 1281891
SGTC_2580 diallyl disulphide 81.36 µM -2.47981863309766 0.00636134490077218 no 3310 0.00657246126588316 1067 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1180 1193-0155 285 µM -2.48919320965398 0.00618839601190604 no 3311 0.00640166827321396 1086 2921347
SGTC_1603 st002045 67.8 µM -2.49128441414488 0.00615038893062304 no 3312 0.0063641092655192 1085 5887985
SGTC_1865 st057639 52.2 µM -2.51432449929015 0.00574513338618718 no 3313 0.0059630321850134 1091 688818
SGTC_1455 4262-0120 131 µM -2.52379103022266 0.00558561512883902 no 3314 0.00580484592282984 1081 1529587
SGTC_2511 berberine 10.47 µM -2.5339699183064 0.00541849352573202 no 3315 0.00563892063890373 1073 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_799 1310-0557 151 µM -2.5394477793476 0.00533040773142492 no 3316 0.00555138094344244 1083 5354492
SGTC_767 0929-0023 86 µM -2.54411992038893 0.00525628681173172 no 3317 0.00547767329466316 1084 1204563
SGTC_1612 st002233 45.4 µM -2.5533665006306 0.0051122926589351 no 3318 0.00533435842029207 1076 1035021
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -2.56470874669557 0.00494046575436428 no 3319 0.00516312219245568 1085 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1393 3470-5649 58.2 µM -2.56492422995874 0.00493725175075058 no 3320 0.0051599169013668 1085 4108395
SGTC_86 0417-1630 471.922 µM -2.59151346867308 0.0045546785199178 no 3321 0.00477774005685433 1078 3634867
SGTC_455 paf C-16 10 µM -2.63766456882907 0.00395306695776319 no 3322 0.0041739554661575 1081 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2297 7971671 152.32 µM -2.69012405351018 0.00335644922594012 no 3323 0.00357127310700699 1080 909016
SGTC_665 3914-0008 307 µM -2.69619287367765 0.00329293416630184 no 3324 0.00350685213052333 1090 1069549
SGTC_1764 st044502 93.5 µM -2.70405746525781 0.00321223351885497 no 3325 0.00342492209983469 1087 8407
SGTC_1126 isoteolin 1.0172 µM -2.71765261743386 0.00307691749490093 no 3326 0.00328734129975211 1088 133323
SGTC_53 0973-0023 39.979 µM -2.72451067452814 0.00301062440214039 no 3327 0.00321984243269502 1081 674768
SGTC_3198 9112019 49.47 µM -2.77833828766801 0.00253338777081297 no 3328 0.00273188510594418 1091 45595555
SGTC_2416 tofa 880 nM -2.80652379949377 0.00231179724954407 no 3329 0.00250396064787182 1083 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2388 9080168 200 µM -2.81332474346838 0.00226102836826994 no 3330 0.00245160529144103 1087 15943073
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -2.85403163673625 0.00197770460387872 no 3331 0.00215841161031911 1085 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1253 0550-0034 176 µM -2.90118572800688 0.00169006008087852 no 3332 0.00185876733873857 1087 5969915
SGTC_1369 1866-0067 208 µM -2.94841934230889 0.00144062678436369 no 3333 0.00159701738033639 1078 3531355
SGTC_2833 9001315 45.46 µM -3.01883459535651 0.00113069832684564 no 3334 0.00126874513841135 1080 2989378
SGTC_181 1447-1644 8.07 µM -3.01934178975958 0.00112870660426989 no 3335 0.00126662281982334 1087 534600
SGTC_2704 st078022 71.1 µM -3.03822726020575 0.00105679357399374 no 3336 0.00118987206478992 1088 54697681
SGTC_78 0336-0123 156.75 µM -3.10897201140774 0.000823176442433613 yes 3337 0.000938697509808497 1088 6765896
SGTC_395 anisomycin 6.25 µM -3.11785054436191 0.000797481498250786 yes 3338 0.000910875797289307 1093 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2622 2-methoxyxanthone 59.94 µM -3.16010607566139 0.000685010587529443 yes 3339 0.000788558545223269 1093 71034 A hepatoprotective.
SGTC_276 colchicine 750 µM -3.16237880590686 0.000679397346587425 yes 3340 0.000782429287479791 1093 2833 A microtubule depolymerizer.
SGTC_2365 9042475 200 µM -3.18980020289707 0.000614934642171229 yes 3341 0.000711855923915838 1085 6464479
SGTC_97 0535-0701 19.132 µM -3.20389390085595 0.000584046537214526 yes 3342 0.00067791215642848 1077 2832013 YGL099W LSG1
SGTC_1258 0671-0043 57.1 µM -3.32203080406009 0.000376167226481761 yes 3343 0.000446824137464483 1091 4298767
SGTC_1372 2752-0194 270 µM -3.35402799189731 0.000333092967417419 yes 3344 0.000398221527077146 1090 823334
SGTC_447 ml7 120 µM -3.47397634648666 0.000209181295987955 yes 3345 0.000256403118725566 1095 4216 Selective myosin light chain kinase inhibitor.
SGTC_1698 5-fluorocytosine 1.055 µM -3.55900410273362 0.000149079432645152 yes 3346 0.000186131858592565 1094 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2830 7992007 71.43 µM -3.60436047930524 0.000124058639569536 yes 3347 0.000156461245881187 1091 1952075
SGTC_272 doxorubicin 8.13 µM -3.64126920069572 0.000106664162246965 yes 3348 0.000135648636883573 1093 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1934 st074720 32.6 µM -3.65975541319122 9.8839042956834e-05 yes 3349 0.000126228050041988 1090 17250992
SGTC_2242 6630449 61.2675 µM -3.70300259556178 8.25883922817647e-05 yes 3350 0.000106531350694046 1094 691249 YDR170C SEC7
SGTC_1006 4099-6547 255 µM -3.72122994546095 7.65225358277493e-05 yes 3351 9.91274035597716e-05 1091 3146833
SGTC_423 5-fluorouracil 457 µM -3.96810374802392 2.63257320128799e-05 yes 3352 3.62233976876598e-05 1090 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2815 7968870 71.43 µM -3.97889588800222 2.50897789067871e-05 yes 3353 3.46180245720791e-05 1094 2977326 YHR190W ERG9
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -4.29227790762682 5.8903475991817e-06 yes 3354 8.84247037178609e-06 1094 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1373 2887-0003 58.5 µM -4.41152642884114 3.30354127191044e-06 yes 3355 5.13222112132525e-06 1095 776948
SGTC_3206 9114350 49.47 µM -5.32984098276876 2.33213395235048e-08 yes 3356 4.91493987402848e-08 1095 17087243