SGTCid condition conc unit MHO1|YJR008W.score MHO1|YJR008W.strain.pval MHO1|YJR008W.strain.significant MHO1|YJR008W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2429 5902844 64.44 µM 8.37342185280127 1.91652480670648e-18 yes 1 2.798440255375e-17 2 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_372 0155-0182 15.9 µM 5.54038694694673 4.60167910246273e-09 yes 2 1.50902013001271e-08 7 771486 SGTC_915 methyl methanesulfonate (MMS) 110 mM 4.72431544288092 4.83489694804302e-07 yes 3 1.15445895030821e-06 21 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2695 st077686 51.995 µM 4.67005828510472 6.42828713589903e-07 yes 4 1.50557144332866e-06 19 2876092 SGTC_2421 5690543 90.72 µM 4.54735376090587 1.21050867428797e-06 yes 5 2.71623212283258e-06 11 3397993 SGTC_794 k038-0031 316 µM 4.29974144724748 4.14005217192392e-06 yes 6 8.54987439264841e-06 98 6624242 SGTC_333 3486-0131 40.1 µM 4.26901067314924 4.80133910337981e-06 yes 7 9.8170937435795e-06 8 6744690 SGTC_101 0490-5701 117.494 µM 4.13759850365295 8.94928883921662e-06 yes 8 1.75479897645393e-05 9 4661669 SGTC_920 mycophenolic acid 780.421 nM 4.07184944437932 1.21391070525315e-05 yes 9 2.33206620717809e-05 25 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1629 st005085 44.9 µM 3.96860553387261 1.94172145790238e-05 yes 10 3.61472198135303e-05 35 24207091 SGTC_2464 5717415 7.67 µM 3.72374668307498 5.66232698130136e-05 yes 11 9.81439413054477e-05 23 5285744 SGTC_918 glabranin 770.725 nM 3.69913838279164 6.28395059055031e-05 yes 12 0.000108166315441129 41 124049 Also referred to as licorice root. SGTC_79 0052-0007 94.094 µM 3.62896887308229 8.42849879990278e-05 yes 13 0.000142277772583813 50 2801472 SGTC_2628 lathosterol 100 µM 3.36159602636316 0.000246412384369942 yes 14 0.000387467030989622 50 6710616 SGTC_2483 5729050 27.16 µM 3.33255214953054 0.00027565947171113 yes 15 0.000430266706429231 47 2865180 SGTC_2949 9072542 2.23 µM 3.29084376270943 0.000323350753418411 yes 16 0.000499436868970091 69 16457352 SGTC_1991 st073000 8.92 µM 3.26723012442739 0.000353647131095875 yes 17 0.000543026796497042 116 4301969 YIL048W NEO1 SGTC_2851 9015922 71.43 µM 3.21819557812129 0.000425164559453207 yes 18 0.00064499912220195 76 2996893 SGTC_2603 homopterocarpin 100 µM 3.2180199861946 0.000425443204097122 yes 19 0.000645394116217239 88 101795 A weak amylase inhibitor. SGTC_3196 9111891 49.47 µM 3.18903515422178 0.000473831762154275 yes 20 0.000713742584889352 40 18891510 SGTC_336 4111-0029 111 µM 3.16259908153501 0.000522362198797055 yes 21 0.000781837570632587 19 3131175 SGTC_3189 9110682 49.47 µM 3.15071268093416 0.000545648034777446 yes 22 0.000814363131935844 64 17122418 SGTC_169 k015-0017 16.025 µM 3.1452924769888 0.000556581913288879 yes 23 0.000829604311963743 40 1840002 SGTC_1901 st060216 58.6 µM 3.14030731681268 0.000566816699383391 yes 24 0.000843853442310462 58 688792 SGTC_2739 tacrine 100.86 µM 3.08731733875641 0.00068689096852251 yes 25 0.00100985928309616 47 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2306 7482397 179.52 µM 3.07424192813734 0.000719928268874861 yes 26 0.00105519109664496 55 891448 SGTC_2812 7970281 58.44 µM 3.07212676888168 0.000725408209587572 yes 27 0.0010626972070373 78 2233435 SGTC_2620 irigenin 100 µM 3.05789701328287 0.000763285411222698 yes 28 0.00111448082566995 77 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1675 st018485 24.5 µM 3.0515591239702 0.000780735213840375 yes 29 0.00113828104271882 71 3323024 SGTC_3316 9136639 10.545 µM 3.00249224760333 0.000928775136138763 yes 30 0.00133889396799888 52 4903665 SGTC_1460 k062-0059 9.15 µM 2.97644599234164 0.00101744828461492 no 31 0.0014580521983599 58 1373085 SGTC_1210 3013-0140 750 nM 2.96901944983158 0.00104411852958509 no 32 0.00149375843070255 39 905973 SGTC_906 1165-0455 526 µM 2.92943756601569 0.00119739671122895 no 33 0.0016978801165897 41 3252859 SGTC_779 1360-0071 233 µM 2.90399254076906 0.00130653171324996 no 34 0.00184218468932268 87 7566 SGTC_1332 1480-0653 17.5 µM 2.90395813426784 0.00130668524994967 no 35 0.00184238714599528 59 5749438 SGTC_2858 9025781 8.96 µM 2.88824872494889 0.00137853577630087 no 36 0.00193696704992342 176 4894980 YPL153C RAD53 SGTC_3097 9117246 49.47 µM 2.81989754651986 0.00173507591768334 no 37 0.00240194923127956 68 16423892 SGTC_2486 5283202 22.39 µM 2.80441108272186 0.00182671889471684 no 38 0.00252042946844391 95 1377751 SGTC_2113 5491891 107.031 µM 2.7973134832268 0.00187017276510043 no 39 0.00257647547933646 99 789979 SGTC_1271 0832-2808 169 µM 2.77620373707728 0.00200502403056958 no 40 0.00274988664055739 69 3663794 SGTC_2722 naftopidil 47.16 µM 2.76305925553793 0.00209339180393465 no 41 0.00286311848888417 60 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2726 cimetidine 79.27 µM 2.74738191376642 0.00220339892745193 no 42 0.00300365684926543 41 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_797 k781-0471 270 µM 2.74489908218905 0.00222129362853746 no 43 0.00302647541023817 80 23738129 SGTC_1094 duloxetine 25.4 µM 2.73063717585452 0.00232665973245508 no 44 0.00316060101627059 88 60834 A selective serotonin reuptake inhibitor. SGTC_722 3534-0461 190 µM 2.7277462432271 0.0023485615864409 no 45 0.00318843212616946 112 658262 SGTC_1711 st032263 62.8 µM 2.72539645336419 0.00236650103712274 no 46 0.00321121589687845 74 3958979 SGTC_3198 9112019 49.47 µM 2.7241179597577 0.00237631370198413 no 47 0.00322367371990234 77 45595555 SGTC_2454 5-benzylidenerhodanine 10.36 µM 2.70279458442645 0.00254549530389975 no 48 0.00343796125171299 123 1273210 SGTC_1995 st072814 61.1 µM 2.67265457756247 0.00280321379416793 no 49 0.00376268473867424 79 5769371 SGTC_3221 9128209 49.47 µM 2.6533769000291 0.00298016394121903 no 50 0.00398454161617356 86 16460723 SGTC_460 trequinsin 123 µM 2.63564003694035 0.00315179542376699 no 51 0.00419893829110978 39 5537 A vasodilator. SGTC_2706 st078239 82.5 µM 2.6197759135917 0.00331278814993166 no 52 0.00439937814655859 82 15434492 SGTC_2365 9042475 200 µM 2.6175565054782 0.00333589127620861 no 53 0.00442809120836016 123 6464479 SGTC_210 3551-0445 56.827 µM 2.60190514726677 0.00350297014853534 no 54 0.00463537446763701 138 2865180 YOR207C RET1 SGTC_2723 salbutamol 83.58 µM 2.57405843385612 0.00381890495954878 no 55 0.00502566479724063 39 9884233 β2-adrenoceptor agonist SGTC_725 1497-0963 19 µM 2.55662255162623 0.00402950009805957 no 56 0.00528469166590148 91 3549977 SGTC_1359 1582-0056 520 nM 2.54743532594722 0.00414459743639873 no 57 0.00542589829715006 101 3661189 SGTC_902 1120-0002 2.07 µM 2.54228269840426 0.00421042898293449 no 58 0.00550655290162347 143 3280475 SGTC_2717 st081029 62.2815 µM 2.52375626294268 0.00445492299322049 no 59 0.00580542000741742 76 5292846 SGTC_2806 7952793 58.44 µM 2.50286172280429 0.00474581967319002 no 60 0.00615968326357558 116 2972490 SGTC_2449 5812982 45.77 µM 2.50109183130004 0.0047712218772147 no 61 0.00619055347796879 78 776185 SGTC_165 k038-0023 64.381 µM 2.49249137693565 0.00489639316896269 no 62 0.00634252053304669 201 46368543 SGTC_1710 st031758 61.5 µM 2.48171585530002 0.005057345667612 no 63 0.00653757457953276 92 5394341 SGTC_158 k038-0087 26.446 µM 2.47952507983717 0.00509063947001191 no 64 0.00657787389158263 274 X158 SGTC_370 0180-0345 38.7 µM 2.47649233812717 0.00513705087033246 no 65 0.00663402363996781 91 3989527 SGTC_2973 9094665 17.96 µM 2.47385044976929 0.0051777874147201 no 66 0.00668328182121237 145 25237061 YIL048W NEO1 SGTC_653 0203-0016 55.2 µM 2.45389430324186 0.00549490178126329 no 67 0.00706592562188186 114 295302 SGTC_2621 lithochol-11-enic acid 100 µM 2.42329159168076 0.00601476009511978 no 68 0.00769028778892327 157 6708711 SGTC_2750 bromebric acid 70.15 µM 2.40224918600283 0.00639706616133288 no 69 0.00814730220687746 156 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_424 splitomicin 100 mM 2.40044214150569 0.00643087876309646 no 70 0.00818763962518105 135 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1478 0453-0656 35.7 µM 2.37983029573681 0.00682789334102919 no 71 0.00866030635103764 110 5258496 SGTC_2639 lactacystin 53 µM 2.37039398393241 0.00701676655163621 no 72 0.00888456954425352 145 3870 A proteasome inhibitor. SGTC_1456 k015-0012 13 µM 2.36053081200957 0.00721909817905265 no 73 0.00912440114357464 159 2989616 SGTC_1994 st072947 40.9 µM 2.36023935890484 0.00722515447992782 no 74 0.00913157348187541 140 5286565 YDL195W SEC31 SGTC_1762 st045503 25.4615 µM 2.34245813098525 0.00760322218452079 no 75 0.00957859164876315 145 4645554 SGTC_912 3474-0017 2.18 µM 2.34032007918487 0.00764983507880258 no 76 0.00963360969085717 135 3360550 SGTC_220 paclitaxel 373.376 µM 2.31341231049573 0.00825833223097118 no 77 0.0103499904458591 97 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1820 st053765 18.6 µM 2.3123466279094 0.0082832832966058 no 78 0.0103792945257587 143 3690829 SGTC_1044 1222-0021 1.78 µM 2.30815204887669 0.00838213620263215 no 79 0.0104953405540211 173 4306703 SGTC_297 0986-0032 24 µM 2.27500137606989 0.00920050435524941 no 80 0.0114529236420555 107 2847425 SGTC_2945 9067681 61.76 µM 2.2691250752575 0.00935264700466681 no 81 0.0116303604500223 111 16456930 SGTC_193 1273-0060 1.558 µM 2.26298390034338 0.00951399503565291 no 82 0.0118183408779565 96 2847393 YHR072W ERG7 SGTC_48 0382-0018 55 µM 2.2518851301363 0.00981177539305562 no 83 0.0121647660298712 133 762596 SGTC_2443 5493264 126.67 µM 2.25088993540196 0.00983886999157381 no 84 0.0121962546795821 142 5340055 SGTC_3098 9119039 49.47 µM 2.25044259888396 0.00985107018975584 no 85 0.012210431713502 170 17161528 SGTC_1179 1021-1431 9.29 µM 2.2397554188429 0.0101464954934685 no 86 0.0125534027803794 215 2840958 SGTC_2570 licareol 100 µM 2.23452332558532 0.0102939235633857 no 87 0.0127243297636338 177 443158 SGTC_2725 haloperidol 53.21 µM 2.22160860284044 0.0106658510648371 no 88 0.0131548839927353 191 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1283 0922-0125 16.4 µM 2.21822402315936 0.0107652372511358 no 89 0.0132697807692686 156 3360884 SGTC_2951 9072950 58.06 µM 2.21027776515405 0.0110017485702981 no 90 0.013542945392699 188 16488155 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.20810123353786 0.0110673140503404 no 91 0.0136186085234681 259 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2273 7815444 169.05 µM 2.14296831850368 0.013192961295178 no 92 0.0160578212015602 175 2824616 SGTC_3345 9148410 3.559 µM 2.1428367655162 0.0131975887927168 no 93 0.0160631039977247 119 4903596 SGTC_2170 morpholine 200 µM 2.14090095239436 0.0132658451286044 no 94 0.0161410131674693 148 121171 Reacts with secondary amines. SGTC_2702 st077768 96.8 µM 2.13875626372288 0.0133418222492158 no 95 0.0162277066402718 171 6484119 SGTC_2412 st077135 33.4 µM 2.13695275025189 0.0134060036020467 no 96 0.0163009174419387 194 13258915 SGTC_1859 st055998 20 µM 2.13304910350473 0.0135458356708646 no 97 0.016460349156032 182 676301 SGTC_2389 9091542 195.52 µM 2.13288168187435 0.0135518609116683 no 98 0.0164672166973208 204 3626624 YOL127W RPL25 SGTC_2749 bexarotene 57.39 µM 2.12059339875657 0.0140004588897151 no 99 0.0169780170655362 221 82146 An retinoic acid receptor inhibitor. SGTC_780 0109-0199 192 µM 2.11478298846932 0.0142169942919648 no 100 0.0172242237073455 223 610414 SGTC_3239 9133757 49.47 µM 2.11004858971185 0.0143955573498514 no 101 0.0174270854115018 107 17036923 SGTC_87 0100-0052 35.5 µM 2.10151914443302 0.0147221305846057 no 102 0.0177977096208308 419 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_990 3985-0011 41.3 µM 2.09725070574993 0.0148879385270736 no 103 0.0179856940081198 165 5399565 YGL099W LSG1 SGTC_1438 4092-1045 4 µM 2.08506733135172 0.0153700625231858 no 104 0.0185315945787525 167 1351342 SGTC_480 am 92016 50 µM 2.07156812498415 0.0159198541192051 no 105 0.0191528675519216 160 2129 K+ channel blocker. SGTC_2517 totarol 10 µM 2.05774934072376 0.0165000407700705 no 106 0.0198071006517071 186 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2067 5224629 34.075 µM 2.05378576008781 0.016669757207195 no 107 0.0199982158855444 216 2835000 SGTC_3281 9140613 49.47 µM 2.04754463677465 0.0169400227836432 no 108 0.0203023194311878 178 16013766 SGTC_1654 st012436 41.8 µM 2.04183664560343 0.0171904730280378 no 109 0.0205838689401352 163 4323132 SGTC_2082 5219693 150 µM 2.02260175549576 0.0180578685942515 no 110 0.0215571115353513 236 2834649 SGTC_1697 st025554 27.742 µM 2.00871990335035 0.0187068108347619 no 111 0.02228342336133 191 1269519 SGTC_205 1486-1330 71.903 µM 1.99272336036087 0.0194791218021637 no 112 0.0231458739628795 155 4118834 SGTC_1435 4092-0789 56.7 µM 1.98760883503728 0.0197316955626078 no 113 0.0234274842117674 199 2248285 SGTC_1821 st053465 65.6 µM 1.97802145439898 0.0202126489848616 no 114 0.0239631431992007 176 675086 SGTC_3085 9117376 49.47 µM 1.97221046362752 0.0205089693008177 no 115 0.0242927928369768 211 16480349 SGTC_923 1900-2434 73.3 µM 1.96680532835828 0.0207878897350303 no 116 0.0246028290328786 242 5910570 SGTC_1286 0929-0070 131 µM 1.96185572391395 0.0210461141068407 no 117 0.0248896419421013 250 1420408 SGTC_293 4049-0273 38.5 µM 1.95990358299656 0.0211487024168584 no 118 0.0250035303813915 190 1380311 SGTC_881 0833-0569 170 µM 1.95429950689557 0.0214455592405167 no 119 0.0253329035729884 261 5418700 SGTC_216 k038-0035 28.382 µM 1.95255133681183 0.021538880362352 no 120 0.025436391115099 205 4444231 YPR107C YTH1 SGTC_1695 st026914 34.495 µM 1.9373728935039 0.0223636581998077 no 121 0.0263498888190017 230 3289191 SGTC_1342 1486-1464 234 µM 1.93658622242822 0.0224071213411479 no 122 0.0263979717306973 231 3253938 SGTC_337 1315-0038 354 µM 1.93464130097009 0.0225148830715268 no 123 0.0265171640665788 227 1626437 SGTC_1016 4226-1401 38 µM 1.93307826309936 0.0226018022943508 no 124 0.0266132786903708 250 2901613 SGTC_2936 9038235 15.59 µM 1.92506286256544 0.0230519890653343 no 125 0.0271107471566371 247 4749415 SGTC_3138 9097216 49.47 µM 1.92326392993225 0.0231540575382878 no 126 0.027223456038745 222 25237486 SGTC_86 0417-1630 471.922 µM 1.91659635804648 0.0235356893000851 no 127 0.0276446155300153 409 3634867 SGTC_682 0kpi-0099 17 µM 1.91576918608042 0.0235834010043389 no 128 0.027697240775038 292 1714895 YML126C ERG13 SGTC_219 mitoxanthrone 164.414 µM 1.90725771806574 0.0240790893467837 no 129 0.0282436112931734 267 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2492 derrusnin 100 µM 1.90088564715946 0.0244558881813411 no 130 0.0286584962299835 169 1715307 Part of coumarin class of compounds. SGTC_3050 9093513 49.47 µM 1.90053591583014 0.0244767112846725 no 131 0.0286814131607428 223 25236664 SGTC_2495 cafestol 54.53 µM 1.89983934165802 0.0245182298512777 no 132 0.0287271031530654 254 16667697 An anti-infammatory. SGTC_1992 st073643 23.3 µM 1.89648062649138 0.0247192530221233 no 133 0.0289482597019392 212 3161292 SGTC_2193 5925765 200 µM 1.89485784291348 0.0248168729089422 no 134 0.0290556187750106 189 877370 SGTC_153 4077-0274 519.67 µM 1.8823430490663 0.0255806252945766 no 135 0.0298947265260426 228 3121976 SGTC_1307 1187-1599 12.2 µM 1.86487018652209 0.0266797957974028 no 136 0.0310998011419699 245 1538471 SGTC_926 2268-1401 59.4 µM 1.85846689173615 0.0270923647064352 no 137 0.0315513703978832 270 2931578 SGTC_690 glyoxal 20.3 µM 1.85779101199486 0.027136221098063 no 138 0.0315993489977467 343 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_391 gliotoxin 8.33 µM 1.85620639305965 0.0272392759206382 no 139 0.0317120726051556 302 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2606 farnesol 9.78 µM 1.85460210688491 0.027343942170987 no 140 0.0318265335245056 270 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1241 0364-0022 50.8 µM 1.85054221645896 0.027610315350729 no 141 0.0321177196279525 287 4563895 SGTC_2416 tofa 880 nM 1.84156321750265 0.0282071231667942 no 142 0.0327695327634868 301 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_515 4092-1064 102 µM 1.84137246312677 0.0282199176379532 no 143 0.0327834976514585 351 717353 SGTC_3317 9138495 8.753 µM 1.83796757840358 0.0284491074086175 no 144 0.0330335914617833 289 17020139 SGTC_284 0988-0104 32.6 µM 1.83112276919253 0.0289145328285119 no 145 0.0335411103619422 258 4666532 SGTC_717 1532-0246 73.2 µM 1.82949650520421 0.0290260392599206 no 146 0.033662631190084 290 9561992 SGTC_2687 chenodiol 100 µM 1.82943060156347 0.0290305655328666 no 147 0.0336675633978324 250 5702181 A cholesterol synthesis inhibitor. SGTC_1403 3909-7815 62.9 µM 1.8260777117567 0.029261617707317 no 148 0.0339192784787179 218 6615483 SGTC_2387 9077560 195.08 µM 1.82465306689199 0.0293602532262625 no 149 0.0340266999526542 281 5303272 SGTC_1570 verbenone 133 µM 1.82272423545265 0.0294942359764259 no 150 0.0341725838826952 267 29025 A natural terpanoid with antifungal properties. SGTC_1446 4239-0190 62 µM 1.82159752025129 0.0295727357600325 no 151 0.0342580387384947 327 1340085 SGTC_49 0717-0965 32.132 µM 1.81709392675752 0.0298882410800721 no 152 0.0346013662719014 287 5889349 YGL099W LSG1 SGTC_523 1934-0222 13.7 µM 1.81678353654626 0.0299100883405065 no 153 0.0346251323328087 298 1361595 SGTC_1881 5652484 16 µM 1.81484805055707 0.0300466192967243 no 154 0.0347736319021882 296 2255129 SGTC_2700 st077718 96.8 µM 1.79460086190162 0.0315060933801446 no 155 0.0363586578672451 235 904970 SGTC_1783 st039459 87.517 µM 1.79351215168363 0.0315862026853464 no 156 0.0364455346817388 331 729761 SGTC_327 1273-0057 3.96 µM 1.79155962668455 0.0317302947511229 no 157 0.0366017676136066 280 3108138 SGTC_1235 benzylparaben 21.5 µM 1.77771434604586 0.032767698070294 no 158 0.0377253911437914 278 7180 SGTC_2995 9067767 71.4286 µM 1.76607092492894 0.0336616218690698 no 159 0.038691975316731 261 11673567 SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.76435414669555 0.0337951096773652 no 160 0.0388361864993998 315 140250 A respiratory chain inhibitor. SGTC_2216 7189485 200 µM 1.76354730192134 0.0338579960324892 no 161 0.0389041133735075 214 731273 SGTC_50 0929-0078 56.389 µM 1.75938612866351 0.0341838525851916 no 162 0.0392559731858788 313 1377751 SGTC_3296 9122258 64.045 µM 1.75621439273366 0.0344339552335743 no 163 0.0395259040300411 319 4730474 SGTC_2841 9004761 38.96 µM 1.75448942322342 0.0345706051884736 no 164 0.0396733403301001 286 2991039 SGTC_752 1896-0090 130 µM 1.75417171350945 0.0345958222735773 no 165 0.0397005442675143 300 772567 SGTC_2710 st078562 53.7235 µM 1.75373560403653 0.0346304615228126 no 166 0.0397379108975539 281 17250908 SGTC_1560 lithocholic acid 53.1 µM 1.74391573325734 0.0354180047768946 no 167 0.0405868923755597 193 9903 A bile acid which acts as a detergent. SGTC_678 1218-2179 85.9 µM 1.7374184678549 0.0359471074758946 no 168 0.041156666904808 218 6820081 YOR116C RPO31 SGTC_1480 1070-0044 41.2 µM 1.73225627496097 0.0363720896750917 no 169 0.0416139716893642 314 3124987 SGTC_2502 avocadyne acetate 18.59 µM 1.73163425721671 0.0364235743186664 no 170 0.0416693513791815 378 3952079 SGTC_2490 carminic acid 95.39 µM 1.72686439009839 0.0368203632407192 no 171 0.0420960105362982 224 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1030 k029-0042 36.7 µM 1.7260207122051 0.0368909124647956 no 172 0.0421718432943117 358 6080581 SGTC_2698 st077697 67.5 µM 1.71769055977607 0.0375934381481443 no 173 0.0429265360843054 295 3154499 SGTC_3079 9117512 49.47 µM 1.71287088617681 0.0380048702133859 no 174 0.0433681477246343 234 7185044 SGTC_278 4092-0821 23.9 µM 1.71119943934122 0.038148408506645 no 175 0.0435221510801547 304 877900 SGTC_1617 st002906 78 µM 1.71088144904277 0.0381757664525166 no 176 0.0435514999091745 334 5150859 SGTC_1919 st067113 52.3 µM 1.70669009146063 0.0385378628736155 no 177 0.0439398349341839 348 1268243 SGTC_32 0928-0142 34.1 µM 1.70513198137531 0.0386731814913236 no 178 0.0440849060839283 261 2244242 SGTC_792 4534-1957 155 µM 1.70484855063301 0.038697838427122 no 179 0.0441113369730233 293 1717904 SGTC_484 loperamide 105 µM 1.7035334652977 0.0388124113398998 no 180 0.0442341404027242 194 3955 An opioid-receptor agonist. SGTC_2313 7726885 200 µM 1.69963805633737 0.0391534094744631 no 181 0.0445995137001027 333 726423 SGTC_1343 1487-0095 224 µM 1.69883411012355 0.0392240883930546 no 182 0.0446752223374056 295 4560101 YGL055W OLE1 SGTC_1374 2889-5571 141 µM 1.69300021376436 0.0397400914263477 no 183 0.0452277132594384 372 2853281 SGTC_2465 5809242 33.21 µM 1.68982170295146 0.0400235423581732 no 184 0.0455310352157188 238 2731748 SGTC_2444 5485484 36.41 µM 1.68966137773058 0.0400378831359788 no 185 0.0455463781124754 355 6790631 SGTC_2727 riluzole 51.77 µM 1.68477997633087 0.0404765175222688 no 186 0.0460155147778901 286 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2813 7971799 71.43 µM 1.68377810312461 0.0405670249332674 no 187 0.0461122802594043 311 2234054 SGTC_2084 5306078 60.6385 µM 1.68356243590376 0.0405865293913593 no 188 0.0461331317462572 330 679340 SGTC_429 1112-0049 25.5 µM 1.68109106829948 0.0408105781452653 no 189 0.046372613503669 324 2836170 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.67867143772569 0.0410309077025113 no 190 0.0466080477230426 358 5106787 A p450 inhibitor. SGTC_2227 7312221 64.1025 µM 1.67690733940928 0.0411921523295216 no 191 0.0467803013654785 247 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_3087 9117406 49.47 µM 1.67542074364812 0.0413284308129159 no 192 0.0469258547243881 304 42546093 SGTC_36 0335-0881 14.2 µM 1.67219651309537 0.0416252568051039 no 193 0.047242788929487 433 23828853 SGTC_1021 4476-0760 85.3 µM 1.6676149691143 0.0420500065309088 no 194 0.0476960923814399 357 746768 SGTC_1977 st070720 65.3 µM 1.66727001480295 0.0420821283518536 no 195 0.0477303630971817 295 682188 SGTC_3102 9121669 49.47 µM 1.6667877209471 0.0421270723936754 no 196 0.0477783113540995 272 41905072 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.66564474239775 0.0422337395069417 no 197 0.0478920969790055 349 688751 SGTC_2081 5214970 32.255 µM 1.66416636602101 0.0423720312443374 no 198 0.0480395937225337 320 2063512 SGTC_2173 5763948 167 µM 1.66053439219514 0.0427133326278259 no 199 0.0484034975337175 342 2867177 SGTC_2337 9009472 200 µM 1.65833037352593 0.0429215284113967 no 200 0.0486254007992255 401 5742383 SGTC_1464 k208-0027 110 µM 1.65738980816856 0.0430106252860707 no 201 0.0487203453105191 352 X1464 SGTC_1768 st044301 37.178 µM 1.65446582362964 0.0432885600588847 no 202 0.0490164509127138 353 3931349 SGTC_3053 9095903 49.47 µM 1.65227292821616 0.0434979525424901 no 203 0.0492394627213859 296 17174018 SGTC_2167 5876490 200 µM 1.64688030325847 0.0440163552255922 no 204 0.0497913255944869 356 686534 SGTC_2476 5806916 10.51 µM 1.64582377799918 0.0441185022318711 no 205 0.0499000226570849 311 2870194 SGTC_289 k017-0060 526 µM 1.63585418852247 0.045091820944759 no 206 0.050935053885001 296 5512909 SGTC_135 0933-0004 26.348 µM 1.63575891746838 0.0451012048260371 no 207 0.0509450266308576 356 21230617 YGL099W LSG1 SGTC_1365 1672-3266 55.4 µM 1.63348065123278 0.0453260749605513 no 208 0.0511839734273656 369 6415873 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.63212729152806 0.0454600811126306 no 209 0.0513263367840838 433 688788 SGTC_1329 1447-1697 50.6 µM 1.62190270796615 0.0464828177741907 no 210 0.0524120908211669 372 2840515 SGTC_3228 9131799 49.47 µM 1.62132902337486 0.046540744642053 no 211 0.0524735468680219 331 17015818 SGTC_1353 1498-1206 8.11 µM 1.6190374800054 0.0467727076398439 no 212 0.0527195995747107 434 6756808 SGTC_1051 3253-3903 78 µM 1.61651185552284 0.0470294390965236 no 213 0.0529918461247617 399 5509239 SGTC_178 4092-0806 87.505 µM 1.61474000763874 0.0472102221276416 no 214 0.0531835048629554 486 2169044 SGTC_2358 9037157 4 µM 1.61455181414683 0.0472294563373413 no 215 0.0532038937786769 363 2388925 SGTC_2965 9082772 38.63 µM 1.61313456076832 0.0473745077560403 no 216 0.0533576383690152 385 16459634 SGTC_1214 0358-0031 63.7 µM 1.60809769768565 0.0478929056558673 no 217 0.0539068916896831 362 4301366 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.60397671821161 0.0483204092089745 no 218 0.0543595922889477 388 2333 A French combination drug. SGTC_883 0850-0245 24.6 µM 1.60207449121405 0.048518770089729 no 219 0.0545695690245077 408 6823229 YPR165W RHO1 SGTC_564 3555-0129 330 µM 1.59916130564798 0.0488238135146701 no 220 0.0548923828122383 273 563260 SGTC_981 1488-1094 54.9 µM 1.59677230717197 0.0490751107730397 no 221 0.0551582355102274 318 3449522 SGTC_413 propylparaben 100 µM 1.59538586845251 0.0492214225182756 no 222 0.0553129870759902 325 7175 A pharmaceutical preservative. SGTC_472 calcifediol 10 µM 1.58786168567533 0.0500215390691794 no 223 0.0561588095046765 296 5283731 A vitamin D metabolite. SGTC_701 4424-0219 185 µM 1.58342308984415 0.0504983786143311 no 224 0.0566625318277998 402 2911779 SGTC_329 k048-0121 21.3 µM 1.58246529175121 0.0506017486593882 no 225 0.0567716948482707 351 6832902 SGTC_1062 mesoridazine 14.2 µM 1.57738981447403 0.0511523338381377 no 226 0.0573529288196626 397 4078 A neuroleptic. SGTC_1309 pyrazolanthrone 13.4 µM 1.57429523954061 0.0514903642709008 no 227 0.0577096049098787 392 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1211 1056-0033 32.3 µM 1.57355753678215 0.0515712075703501 no 228 0.0577948883534996 360 6741922 SGTC_3248 9135562 49.47 µM 1.57237309303679 0.0517012193517902 no 229 0.0579320253145549 394 17650701 SGTC_1526 st051518 75 µM 1.56947397550809 0.0520205436445228 no 230 0.0582687694078388 346 673993 SGTC_879 0831-1030 162 µM 1.56526938356495 0.0524864417249159 no 231 0.0587598793785723 461 1549252 SGTC_2571 chrysanthemic acid 100 µM 1.56189943382047 0.0528622417449648 no 232 0.0591558409479517 365 2743 An insecticide. SGTC_3109 9122853 49.47 µM 1.56123855629009 0.0529361892447534 no 233 0.0592337374596918 374 1234709 SGTC_1998 st075797 76.8 µM 1.55690896679379 0.0534226709339877 no 234 0.0597460501179117 431 24208315 SGTC_3315 9136395 68.55 µM 1.55381649228824 0.0537723117386291 no 235 0.0601140977196456 394 16876844 SGTC_818 4072-2707 53.5 µM 1.55256934408068 0.0539138283559779 no 236 0.0602630270987274 341 882871 SGTC_2172 5754775 163.918 µM 1.55023749975229 0.0541792187552309 no 237 0.0605422611399092 386 2263357 SGTC_1405 3909-7894 12 µM 1.54852563550179 0.0543747056107978 no 238 0.0607478972760097 387 7104060 SGTC_2009 4012297 12.05 µM 1.54587395890489 0.0546786157053441 no 239 0.061067505410581 402 45595307 SGTC_2303 7774051 200 µM 1.54330852428057 0.0549739182043539 no 240 0.0613779681779841 366 2953184 SGTC_1279 0874-0590 65.2 µM 1.5399082614498 0.0553672567540612 no 241 0.0617913583701849 394 3523074 SGTC_2211 7117706 200 µM 1.5389698725893 0.0554761988903658 no 242 0.0619058257194475 361 822771 SGTC_747 3448-8087 38.7 µM 1.53086947502553 0.0564236631638692 no 243 0.0629008273669393 442 5168703 SGTC_1440 4100-1550 40 µM 1.527682656503 0.0567998873140921 no 244 0.0632956741348777 328 742806 SGTC_1504 k297-0033 30 µM 1.52690507001965 0.0568919855383719 no 245 0.0633923093382006 330 4388117 SGTC_1115 galangin 695.678 nM 1.52531566441973 0.0570806023580514 no 246 0.0635901912740015 450 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2516 gossypol 71.55 µM 1.52441943245594 0.0571871762143281 no 247 0.0637019844206382 418 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_52 0329-0193 875 nM 1.51176695050747 0.058708493348226 no 248 0.0652965799174802 426 3739292 SGTC_566 0958-0068 16.5 µM 1.50838925626312 0.0591199484232901 no 249 0.0657274655562976 356 6815365 SGTC_530 4358-1714 28 µM 1.50312247629517 0.0597660320535939 no 250 0.0664037319081967 490 1564641 SGTC_2297 7971671 152.32 µM 1.50084345994333 0.0600473113429369 no 251 0.0666980274552738 405 909016 SGTC_310 1273-0058 1.06 µM 1.49938919348223 0.0602273399621182 no 252 0.0668863477073698 681 2734232 SGTC_2035 5154463 94.595 µM 1.49661955080042 0.0605713718000143 no 253 0.0672461400036099 452 2769623 SGTC_1704 st028805 70.8 µM 1.49590869737358 0.0606599180929546 no 254 0.0673387247670284 409 2876101 SGTC_2062 5245942 200 µM 1.49558679498574 0.0607000486276435 no 255 0.0673806831887218 446 1376160 SGTC_266 formosanin C 406 nM 1.49069178467528 0.0613128557817645 no 256 0.0680212169854673 451 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.48925087065843 0.061494161860749 no 257 0.0682106598019198 429 16623 A steroid. SGTC_3117 9124945 49.47 µM 1.48791167922962 0.0616630436612985 no 258 0.0683870936047216 356 17592065 SGTC_18 0111-0177 500 nM 1.48348543009027 0.0622238032893258 no 259 0.0689727423292627 540 721752 SGTC_373 0844-0104 25.9 µM 1.47984170373785 0.0626884037997762 no 260 0.0694577481175418 448 5375804 SGTC_1246 0422-0085 105 µM 1.47790371581061 0.0629366097917323 no 261 0.0697167758081784 475 264295 SGTC_3148 9097893 49.47 µM 1.47197738547119 0.063700370739211 no 262 0.0705134922580084 431 17174100 SGTC_1334 1486-0610 236 µM 1.47134999059103 0.0637816470855086 no 263 0.0705982452132611 459 3742339 SGTC_1388 3346-4487 254 µM 1.46788475562548 0.064232007568413 no 264 0.0710677648656259 481 3345614 SGTC_3253 9135987 49.47 µM 1.46765932300437 0.0642613914082955 no 265 0.0710983925833234 385 4182430 SGTC_133 0724-0033 378.92 µM 1.46485814743007 0.0646273804770241 no 266 0.0714798117553716 402 280309 SGTC_621 3584-0052 32.1 µM 1.4644392919227 0.0646822451298926 no 267 0.0715369794836628 448 2273927 SGTC_2528 xanthyletin 44.79 µM 1.46270047502954 0.0649103945052167 no 268 0.0717746780690832 408 65188 An natural product with antifungal activity of unknown mechanism. SGTC_27 0485-0001 32.618 µM 1.46092504827313 0.0651439915404552 no 269 0.072018005853199 318 2054479 SGTC_932 2857-0803 154 µM 1.45839517933759 0.0654779786882668 no 270 0.0723658243283764 480 674898 SGTC_1168 k815-0004 80.5 µM 1.45688768992126 0.0656776242757376 no 271 0.0725736923163941 454 642433 SGTC_1565 sinapyl alcohol 95.1 µM 1.4555727829011 0.0658521501155684 no 272 0.0727553782454394 429 5280507 A phenol propionate derived from cinnamic acid. SGTC_277 nystatin 15.5 µM 1.4517542512004 0.0663610164868457 no 273 0.0732849743180574 463 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1242 0402-0103 60.1 µM 1.44947304983903 0.0666664643209104 no 274 0.0736027606423552 424 432868 SGTC_1509 1326-1131 80 µM 1.44579227626547 0.0671616045051155 no 275 0.0741177365616909 395 768313 SGTC_1703 st026983 48.3 µM 1.44552061495738 0.067198260951545 no 276 0.0741558534059259 467 1104023 SGTC_3008 9078912 71.4286 µM 1.44530078209519 0.0672279352817002 no 277 0.0741867091512009 418 16648731 SGTC_1771 st048882 4.1505 µM 1.44326314311379 0.0675034701274867 no 278 0.0744731790643424 430 4580403 SGTC_3206 9114350 49.47 µM 1.44101164733699 0.0678089372406625 no 279 0.0747906961485839 423 17087243 SGTC_720 r052-1644 49.9 µM 1.43953356735478 0.0680100525217049 no 280 0.0749997032413501 400 1422863 YOR257W CDC31 SGTC_554 4483-2211 187 µM 1.43735968437901 0.0683066787629673 no 281 0.0753079089874633 456 747107 SGTC_367 0335-0881 7.1 µM 1.43631099932542 0.0684501282964158 no 282 0.0754569327754607 496 23828853 SGTC_1603 st002045 67.8 µM 1.43145420394579 0.0691175214490066 no 283 0.0761500415575366 459 5887985 SGTC_1959 st077091 55.8 µM 1.42884957709658 0.0694774941461285 no 284 0.0765237362923916 493 821356 YKL052C ASK1 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.42837270096976 0.0695435569440608 no 285 0.0765923061708204 505 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2883 9059145 45.46 µM 1.42469645404577 0.0700544610686673 no 286 0.0771224822903525 416 16476510 SGTC_2132 5317594 122.667 µM 1.42468671870144 0.0700558178552329 no 287 0.0771238899822577 403 794577 SGTC_1522 st012842 45.6 µM 1.42455339856271 0.0700744003285367 no 288 0.0771431695063691 428 3491067 YOR116C RPO31 SGTC_1531 st059297 52.4 µM 1.42059902742492 0.070627295764603 no 289 0.0777166807009386 464 7566702 SGTC_1827 berberine 7.24 µM 1.41996525124543 0.0707162204775011 no 290 0.0778088988235701 426 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1473 k844-0725 134 µM 1.41987570431095 0.0707287916818847 no 291 0.0778219351171436 515 54682906 SGTC_1829 berberine 14.4 µM 1.41903737586024 0.0708465652061304 no 292 0.0779440598632707 456 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2541 muurolladie-3-one 83.07 µM 1.41438403311178 0.0715030362929657 no 293 0.0786245878012031 467 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2317 5986382 200 µM 1.41418321945744 0.0715314708272012 no 294 0.0786540568277995 460 877883 SGTC_1490 4089-0339 670 nM 1.41023571936907 0.0720921868040267 no 295 0.0792350459813941 417 742542 SGTC_525 k781-2675 26.7 µM 1.40933375337735 0.0722207766788041 no 296 0.0793682513170748 498 3651118 YDL195W SEC31 SGTC_224 benfluorex 43.875 µM 1.40925314128648 0.0722322777912596 no 297 0.0793801646252079 343 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_3153 9100258 49.47 µM 1.40613249400123 0.0726785875193049 no 298 0.0798423925222883 455 25236848 SGTC_1103 duloxetine 36.1 µM 1.40376094682566 0.0730191721501773 no 299 0.0801950234182014 535 60835 A selective serotonin reuptake inhibitor. SGTC_2080 5212524 12.4 µM 1.39946907747301 0.073638643508827 no 300 0.0808361824652618 448 260183 SGTC_1667 st014849 34.6 µM 1.39818676588574 0.0738245046486338 no 301 0.0810284949186778 490 5348460 SGTC_1880 MG-132 525 µM 1.39795200303724 0.0738585705000731 no 302 0.0810637404347102 435 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1835 st008666 49.2 µM 1.39672731773729 0.0740364763561076 no 303 0.0812477930473593 407 690455 SGTC_416 estradiol valerate 100 µM 1.39299512512069 0.0745806585229207 no 304 0.0818106324164085 462 13791 A steroid. SGTC_3016 9080866 49.47 µM 1.39170185925871 0.0747699371026272 no 305 0.0820063495350314 511 17066299 SGTC_2152 5568786 200 µM 1.39151431564815 0.0747974158357661 no 306 0.0820347608176513 480 5399883 SGTC_2908 7930301 100 µM 1.38976058147084 0.0750547445207917 no 307 0.0823007958335883 515 2223178 SGTC_451 chloral hydrate 100 µM 1.38829962439439 0.0752696285105885 no 308 0.0825229132773121 569 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1232 0279-0259 161 µM 1.3878908356599 0.0753298388517398 no 309 0.0825851444330498 492 1560000 SGTC_1498 4478-3555 97.6 µM 1.38403036270482 0.0759002582190178 no 310 0.0831745789488912 410 3437919 SGTC_1441 4106-0040 13 µM 1.38128875050987 0.0763073491810828 no 311 0.0835950978578791 482 2904180 SGTC_1320 1313-0481 95.3 µM 1.37937233446282 0.0765928952537382 no 312 0.0838899923034195 496 6813365 YLR208W SEC13 SGTC_1889 st059080 5.18 µM 1.37704243655479 0.0769411439272988 no 313 0.084249564003369 527 176925 Isolated from Daphnopsis sellowiana. SGTC_2818 7996756 12.99 µM 1.37675406540762 0.0769843301871292 no 314 0.0842941484660993 385 2241621 SGTC_551 k048-0028 34.9 µM 1.37642535354137 0.0770335803123114 no 315 0.0843449915161302 529 6836383 SGTC_2127 5253358 187.912 µM 1.37393770150745 0.0774070759924248 no 316 0.0847305119377918 441 20612 SGTC_2560 caryophyllene 100 µM 1.3730976490827 0.077533511488333 no 317 0.084860995908709 550 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3036 9090181 49.47 µM 1.37204716008318 0.0776918401829857 no 318 0.0850243785680965 468 25236586 SGTC_689 0833-0039 98 µM 1.37164200415344 0.0777529704399208 no 319 0.0850874554732595 503 5374726 SGTC_2968 9090663 33.37 µM 1.36858362965459 0.0782155990284579 no 320 0.0855647320209462 500 25236811 SGTC_2924 9010168 62.78 µM 1.36678522311967 0.0784886101506438 no 321 0.0858463179154405 522 2993929 SGTC_1716 st033144 30.6155 µM 1.36277833616198 0.079099481617696 no 322 0.0864761903347671 539 674617 SGTC_2195 6536160 144.242 µM 1.35799778294081 0.0798330049422705 no 323 0.0872321938273373 430 3834386 SGTC_2043 5101342 149 µM 1.35198106924339 0.080763501309597 no 324 0.0881906856654508 518 678451 SGTC_2680 butyl paraben 22.24 µM 1.34848860727675 0.0813073607697788 no 325 0.0887506410034429 455 7184 An antifungal and steroid mimetic. SGTC_463 ikarugamyin 104 µM 1.34813728122112 0.0813622231751807 no 326 0.0888071162427021 404 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2373 9071805 200 µM 1.34452449117008 0.0819280105025884 no 327 0.089389421088893 510 10149009 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.3442985214745 0.0819634971586752 no 328 0.0894259367492428 504 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1322 1348-1070 12 µM 1.34345424082095 0.0820961868764888 no 329 0.0895624667797385 467 6758089 SGTC_1362 1611-0397 101 µM 1.33507217275957 0.0834223286339462 no 330 0.0909263630263219 520 27816 SGTC_1701 st028638 40.4 µM 1.33343124828754 0.0836838163197173 no 331 0.0911951617351769 527 3490878 SGTC_1046 2001-0062 216 µM 1.33057920725561 0.0841397645965402 no 332 0.0916637539603349 511 739778 SGTC_11 0438-0307 1.3 µM 1.32739747807726 0.0846506170843679 no 333 0.0921886167509797 497 4011476 SGTC_1293 1000-1278 195 µM 1.32234124534038 0.0854672168274137 no 334 0.0930272720923487 535 678847 SGTC_1876 myriocin 605 nM 1.3208559284733 0.0857082183747337 no 335 0.0932747035314622 523 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_782 0083-0095 30.5 µM 1.3141007561385 0.0868107068238168 no 336 0.0944061498675693 589 3591729 An indicator and reagent. SGTC_3145 9085516 49.47 µM 1.31344546993504 0.0869182150800099 no 337 0.0945164421191886 524 25236195 SGTC_366 0181-0206 4.31 µM 1.30917942821082 0.0876205475912974 no 338 0.0952367894664982 565 274874 SGTC_1825 st052143 62.6 µM 1.30874904154544 0.087691638044943 no 339 0.0953096867820513 482 674173 SGTC_2101 5377231 179.231 µM 1.3018547129238 0.0888363027992245 no 340 0.0964830280930462 531 2844213 SGTC_988 1497-1057 103 µM 1.30049210293326 0.0890638476145698 no 341 0.0967161805711371 538 3533044 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.30009958743691 0.0891294749267382 no 342 0.0967834195314664 587 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_685 1278-0033 54.9 µM 1.2971164701412 0.0896294189147476 no 343 0.0972955576852316 576 3590572 SGTC_455 paf C-16 10 µM 1.29676455058638 0.0896885347380957 no 344 0.0973561057033797 521 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_474 dl-dihydrosphingosine 5 µM 1.29547283781453 0.0899057665094032 no 345 0.0975785827702734 562 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2377 9073351 62.6 µM 1.2941857223023 0.0901226138482439 no 346 0.0978006386449454 549 7337946 YHR072W ERG7 SGTC_3106 9121286 49.47 µM 1.29213979501446 0.0904681016522151 no 347 0.098154368333941 488 15943471 SGTC_179 1273-0063 6.77 µM 1.29182696881871 0.0905210139553494 no 348 0.0982085367869473 494 3108139 SGTC_407 eburnamonine 100 µM 1.28863482610868 0.0910622558950055 no 349 0.0987625350385815 478 3195 SGTC_1648 st011736 69.8 µM 1.28575760102054 0.0915521556235298 no 350 0.0992638358008539 543 2855514 SGTC_1740 st038286 13.222 µM 1.28306605793971 0.0920122052449686 no 351 0.0997344669823781 563 716786 SGTC_2395 5646831 180.19 µM 1.28292325776345 0.0920366609713982 no 352 0.0997594818438113 551 6808628 SGTC_1604 st002052 72.4 µM 1.27749930484018 0.09296912502426 no 353 0.100713012845294 583 6254834 YHR062C RPP1 SGTC_3163 9099914 49.47 µM 1.27708355484863 0.0930408862138403 no 354 0.100786375049265 488 16268368 SGTC_3285 9112818 20.8695 µM 1.27619198219611 0.0931949155615559 no 355 0.100943831106921 607 17017947 YPR165W RHO1 SGTC_1501 4491-0275 38.4 µM 1.27486160010012 0.0934251044892965 no 356 0.10117911637525 551 5104718 SGTC_2352 9027995 87.8 µM 1.27480841640074 0.0934343153037531 no 357 0.10118853050066 504 2997347 SGTC_2013 4024628 200 µM 1.27376448659617 0.093615247948273 no 358 0.101373447309882 529 5230760 SGTC_1072 oxiconazole 14.9 nM 1.27350960262784 0.0936594633975119 no 359 0.10141863362252 597 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_968 1309-0633 340 µM 1.27282957191806 0.0937775057109442 no 360 0.101539262540328 573 3761976 SGTC_1225 1216-0074 20.6 µM 1.2725556201217 0.0938250903249302 no 361 0.10158788766724 563 4241466 SGTC_1733 st037357 54.9 µM 1.26811588331609 0.0945987460337499 no 362 0.102378285089784 580 1272339 YGL099W LSG1 SGTC_1171 0368-0077 21.4 µM 1.26539463242039 0.0950752620725125 no 363 0.102864949190441 530 3239779 SGTC_2228 7354201 200 µM 1.26328299185817 0.0954462462048495 no 364 0.103243748183875 546 753451 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.2607991915756 0.0958839757504015 no 365 0.10369060257689 556 689007 SGTC_1355 1499-0035 1.68 µM 1.25914216692872 0.0961768194556208 no 366 0.103989493101956 562 1548538 SGTC_775 4577-0580 57.3 µM 1.25703200786743 0.0965506960679818 no 367 0.104371022773349 585 2006902 SGTC_2789 5281112 71.43 µM 1.25620493622707 0.0966975269787601 no 368 0.104520838763576 579 765948 SGTC_674 0498-0004 451 µM 1.25529304806674 0.0968596054742982 no 369 0.104686198954916 569 4231473 SGTC_217 ketoconazole 989 nM 1.25496876513179 0.0969172913971989 no 370 0.104745049498104 559 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1850 st056238 17 µM 1.25406174273365 0.0970787733934589 no 371 0.104909782232627 639 5393177 SGTC_1767 st044992 70.3 µM 1.25367744758384 0.0971472510204925 no 372 0.104979634173117 584 9600693 SGTC_1402 3909-7673 35.9 µM 1.25137378908991 0.0975584836494042 no 373 0.105399067747229 567 5328014 SGTC_1229 0139-0193 12.2 µM 1.25088282535069 0.0976462917738939 no 374 0.105488615382924 625 3090752 SGTC_2231 micatex 6.853 µM 1.25017858196211 0.0977723458006753 no 375 0.10561715947531 537 20737 An antifungal of unknown mechanism. SGTC_2068 5226020 147 µM 1.24986480244952 0.0978285482656873 no 376 0.105674469462419 621 1810509 SGTC_1523 st012844 44.7 µM 1.24932183741083 0.0979258571220963 no 377 0.10577369194956 584 4274103 SGTC_888 0916-0002 6.97 µM 1.24931743915128 0.0979266456568711 no 378 0.105774495970949 590 2802138 YIL048W NEO1 SGTC_834 0312-0008 75.7 µM 1.24718971487433 0.0983086570859909 no 379 0.106163971621522 617 6385573 YIL048W NEO1 SGTC_854 0422-0053 192 µM 1.24123299976359 0.0993839279890495 no 380 0.10725984373775 571 3596728 SGTC_1824 st053723 68.6 µM 1.2397916170999 0.0996454049445813 no 381 0.10752623982066 590 675225 SGTC_3184 9108758 49.47 µM 1.23841224777463 0.0998961026013133 no 382 0.10778162077598 565 902885 SGTC_1410 3909-8106 77.9 µM 1.23760806981286 0.1000424727693 no 383 0.107930710380033 574 1039210 SGTC_2796 7949634 45.45 µM 1.23453341105982 0.10060354199444 no 384 0.108502102350038 574 2971588 SGTC_2234 tolnaftate 200 µM 1.23227219715455 0.101017634721747 no 385 0.108923710957649 521 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3193 9111931 49.47 µM 1.23163493807949 0.101134559123945 no 386 0.109042741838607 599 17087244 SGTC_274 sirtinol 40.1 µM 1.23147079732686 0.101164691664682 no 387 0.109073416119326 590 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3120 9124077 49.47 µM 1.23029990953311 0.101379830075272 no 388 0.109292409095647 606 18774327 YGL155W CDC43 SGTC_664 1222-0054 14.9 µM 1.22749894172922 0.101895830531879 no 389 0.109817559662301 628 6813991 SGTC_3134 9127454 49.47 µM 1.22617493630222 0.102140405970597 no 390 0.110066425488756 591 24262820 SGTC_2181 6316240 54.2555 µM 1.22400129190716 0.102542855659887 no 391 0.110475870087569 553 12779990 SGTC_2816 7982706 58.44 µM 1.2204945260687 0.10319456051814 no 392 0.11113873168904 581 2981853 SGTC_2940 9060638 45.86 µM 1.21759797159695 0.10373512638779 no 393 0.111688392815562 611 4027022 SGTC_1868 st057644 42.7 µM 1.21531450577502 0.104162721218024 no 394 0.11212308073447 642 688665 SGTC_849 0386-0493 241 µM 1.21511232126294 0.104200643156453 no 395 0.112161627429106 575 726119 SGTC_2008 4012253 172 µM 1.21358327239374 0.104487757228183 no 396 0.112453448952505 627 603940 SGTC_3327 9140648 26.9345 µM 1.21292001000988 0.104612478065159 no 397 0.112580202213173 582 8029710 SGTC_2159 5658611 73.75 µM 1.21198839095816 0.104787843142672 no 398 0.112758412257335 589 793844 SGTC_1748 st037455 53.6035 µM 1.20781363761936 0.105576300194272 no 399 0.113559477284675 617 580690 SGTC_1956 st077085 54 µM 1.20721353088919 0.105689989974035 no 400 0.11367496041582 648 24208685 SGTC_3301 9125354 19.7965 µM 1.20690127975261 0.105749180720526 no 401 0.113735082393974 550 41905162 SGTC_2915 7971052 15.16 µM 1.20666907145693 0.105793213972452 no 402 0.113779807322568 445 5741558 SGTC_3147 9097027 49.47 µM 1.20445837749278 0.106213087839736 no 403 0.114206230133673 648 25236841 SGTC_112 phenothiazine 287.218 µM 1.20277611357591 0.106533403295809 no 404 0.114531485305267 631 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2880 9042983 58.44 µM 1.20222521674179 0.106638449540435 no 405 0.114638140921646 632 6464714 SGTC_1761 st044296 37 µM 1.19962622957633 0.10713503862806 no 406 0.115142267503672 617 1826700 SGTC_3158 9100007 49.47 µM 1.19823797183144 0.107400975650324 no 407 0.115412193336997 539 19297233 SGTC_1605 st000082 49.1 µM 1.19545173509027 0.107936147041144 no 408 0.1159552914177 615 1114022 SGTC_2990 9074105 71.4286 µM 1.193961464975 0.108223180358719 no 409 0.116246521100605 577 6502001 SGTC_1087 pterostilbene 9.05 µM 1.19340513698476 0.108330472557698 no 410 0.116355372058915 659 5281727 Similar to reservatol, lowers cholesterol. SGTC_1779 st039427 55 µM 1.19323526005598 0.108363249900961 no 411 0.116388624532094 723 1124498 SGTC_3290 9121031 71.43 µM 1.19289074992301 0.108429744209726 no 412 0.116456081191281 559 17014854 SGTC_2319 6033012 152.6 µM 1.19114434975423 0.108767270603 no 413 0.116798460941774 564 847246 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.19108887194158 0.108778005155725 no 414 0.116809348985109 696 66535 A nucleotide analog. SGTC_1198 1612-1005 86.7 µM 1.18906675625762 0.1091697898673 no 415 0.117206699399191 642 6998509 SGTC_828 2074-0507 139 µM 1.18791135020466 0.109394104356843 no 416 0.11743416874761 658 X828 SGTC_142 0335-0849 62.6745 µM 1.18776836813659 0.109421886388138 no 417 0.117462339912295 758 3889043 YPR107C YTH1 SGTC_64 000l-0018 272.079 µM 1.18740915632263 0.109491705147118 no 418 0.117533135038573 735 6811119 SGTC_3033 9090887 49.47 µM 1.18699390944764 0.109572455109286 no 419 0.11761501145165 651 19325384 SGTC_1816 st051957 91.6 µM 1.17948628414887 0.111039788633756 no 420 0.119102297557251 639 674121 SGTC_1226 3909-7979 35.4 µM 1.17853748921664 0.11122622352239 no 421 0.119291197912276 684 6615510 SGTC_2427 5545055 42.75 µM 1.17431763823947 0.112058124379672 no 422 0.120133910481669 697 5372858 SGTC_2126 5251174 33.877 µM 1.17196078395756 0.11252468569239 no 423 0.120606400597127 736 790722 SGTC_441 propafenone 146 µM 1.16649397038858 0.113612230458258 no 424 0.121707392509857 577 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_483 fpl-64176 144 µM 1.16528448598129 0.113853849165932 no 425 0.121951928398166 586 3423 SGTC_3112 9123419 49.47 µM 1.15958187025518 0.114997994082026 no 426 0.123109542947555 679 17015854 SGTC_2874 9043904 71.43 µM 1.15608244604929 0.115704137122558 no 427 0.123823717717836 548 4463428 SGTC_2348 9022543 33.42 µM 1.15377856551408 0.116170711424828 no 428 0.124295482006994 668 3162678 YDL140C RPO21 SGTC_1339 1486-1321 22.7 µM 1.15206690009567 0.11651821572384 no 429 0.124646791716441 664 3469382 SGTC_534 k292-0788 63.4 µM 1.15073942085815 0.116788229252703 no 430 0.124919726801827 735 4146317 SGTC_957 1187-1561 14.1 µM 1.14800528640639 0.117345757920323 no 431 0.125483190752175 675 1538454 SGTC_609 0986-0026 86.3 µM 1.14686964870478 0.117577883679459 no 432 0.125717749184831 684 2848610 SGTC_1244 0416-0015 52.5 µM 1.14648736623246 0.117656095771626 no 433 0.125796775860379 646 96201 SGTC_1511 0906-3109 28.5 µM 1.14529277993986 0.117900736368546 no 434 0.126043947912486 761 2882180 SGTC_2521 angolensin 13.4 µM 1.14480012361894 0.118001732724254 no 435 0.126145982065908 622 821428 A flavenoid. SGTC_427 1354-0053 47.3 µM 1.14301458052928 0.118368288416763 no 436 0.12651626870004 642 6813657 SGTC_3352 9151559 45.5865 µM 1.14281040913304 0.118410254166983 no 437 0.126558658035171 635 17159339 SGTC_2029 5175081 200 µM 1.14129316896774 0.118722439876497 no 438 0.126873971930043 720 1380876 SGTC_1934 st074720 32.6 µM 1.13814776093665 0.119371486822723 no 439 0.127529393810931 720 17250992 SGTC_730 1436-0052 41.2 µM 1.1376488354967 0.119474668457563 no 440 0.127633572945683 635 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1897 st060201 15 µM 1.1360249125496 0.119810943916818 no 441 0.12797306907068 636 611878 SGTC_2931 9014674 55.67 µM 1.13559260671436 0.119900576445262 no 442 0.128063552251808 645 2996810 SGTC_1591 genipin 88.4 µM 1.1305762576313 0.120944103600601 no 443 0.12911674261023 643 442424 A DNA cross-linking agent. SGTC_1314 1222-0010 41.1 µM 1.13046103856661 0.12096814691801 no 444 0.129141003376453 678 3526027 SGTC_60 0986-0278 202 µM 1.13004493402728 0.121055005460994 no 445 0.129228645530031 539 3110598 SGTC_3220 9131269 49.47 µM 1.1182627935098 0.123532662889891 no 446 0.131727386284924 680 17722206 SGTC_1186 1319-0216 26 µM 1.11690574211533 0.123820300908229 no 447 0.132017314605147 733 4565136 SGTC_2974 9094440 9.66 µM 1.11171628666977 0.124924571017296 no 448 0.133130077467021 714 25236134 SGTC_2961 9083290 32.55 µM 1.11141832188107 0.12498818348587 no 449 0.1331941647437 643 17741490 SGTC_152 4469-0003 551.229 µM 1.11113889344638 0.125047859186528 no 450 0.133254284445682 698 697280 SGTC_3084 9116877 49.47 µM 1.11008250901785 0.125273644109442 no 451 0.133481736815492 623 27241325 SGTC_2655 perillic acid 100 µM 1.10799889220873 0.125719817168934 no 452 0.133931147162606 645 5702197 An apoptosis inducer. SGTC_2053 5265679 138 µM 1.10677342609381 0.125982748179542 no 453 0.134195950116925 708 764595 SGTC_3077 9117319 49.47 µM 1.10667954248694 0.126002907264219 no 454 0.134216251631678 649 17154678 SGTC_866 0495-0101 262 µM 1.10609094612545 0.126129344414506 no 455 0.134343578553917 664 635694 SGTC_2031 5180455 200 µM 1.10473706878287 0.126420508173972 no 456 0.134636768089862 664 29949 SGTC_2072 5231554 129 µM 1.1046535888319 0.126438476619545 no 457 0.134654860491969 724 789545 SGTC_611 3453-1652 23.7 µM 1.10179404962167 0.127055045988734 no 458 0.135275608936525 734 1560575 SGTC_1116 jasmonic acid  1.58368 µM 1.09707554763224 0.128077010941683 no 459 0.136304184190746 728 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3015 9080845 49.47 µM 1.09511723359746 0.128502827949773 no 460 0.136732639760984 750 5296973 SGTC_1267 0828-0272 9.49 µM 1.09391205358627 0.128765370950127 no 461 0.136996775873478 760 745334 SGTC_853 0419-0306 21 µM 1.09376008634761 0.128798502725496 no 462 0.137030106868832 667 762713 SGTC_328 k915-0120 63.5 µM 1.09326856161165 0.128905705049636 no 463 0.137137950999078 709 6624543 SGTC_510 ag-490 170 µM 1.08974487096469 0.129676039668114 no 464 0.137912772211067 778 5328779 SGTC_488 nitrendipine 139 µM 1.08880007813757 0.129883127300246 no 465 0.138121028584378 757 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1181 1222-0449 220 µM 1.08761192370483 0.130143881849367 no 466 0.138383232318512 732 658318 SGTC_1843 st055809 45.5 µM 1.08746174610303 0.130176865871047 no 467 0.138416397875225 691 16413835 SGTC_473 2-arachidonoylglycerol 10 µM 1.08677097669398 0.130328656418834 no 468 0.138569018694625 695 5282280 An endocannabinoid. SGTC_1567 st069303 68.4 µM 1.08624275268366 0.130444811616178 no 469 0.138685803543225 734 5581319 SGTC_409 arachidonic acid 100 µM 1.08376639635662 0.130990310991633 no 470 0.139234194021357 716 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1571 st070080 73.4 µM 1.08339285108199 0.131072733303245 no 471 0.139317043734524 713 4315245 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.08281686103279 0.131199895012283 no 472 0.139444859997788 781 16486 A toxic proline analog. SGTC_1077 5-fluorocytosine 377 nM 1.08209571993231 0.131359221902745 no 473 0.139604998724149 695 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2822 7994718 71.43 µM 1.08206840847512 0.131365258643923 no 474 0.139611066043964 621 1018011 SGTC_604 1000-0114 314 µM 1.07914413857014 0.132012728127605 no 475 0.14026173870488 784 1572745 SGTC_2651 TUB2.036 5 µM 1.07886418236284 0.132074829125004 no 476 0.140324138978895 901 15992207 YFL037W TUB2 SGTC_347 4534-1311 26.2 µM 1.07721232214507 0.132441661398371 no 477 0.140692710796779 717 2862016 SGTC_2567 aureobasidin a 60 nM 1.07695985695752 0.132497788698141 no 478 0.140749099994657 714 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1492 4158-0558 28.5 µM 1.0741359883816 0.133126699605077 no 479 0.141380868419854 712 3967268 SGTC_24 0417-1663 219 µM 1.07321956976294 0.133331238355513 no 480 0.141586306105083 705 4329390 SGTC_1815 st051655 58.2 µM 1.07238066179191 0.13351866668138 no 481 0.141774545106316 701 5984156 SGTC_2165 5727197 32.143 µM 1.07231823480009 0.13353262132336 no 482 0.141788559606768 692 1361712 SGTC_3063 1327-0034 4 µM 1.07069492316819 0.133895841099213 no 483 0.142153313137614 713 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_513 4245-1575 41.7 µM 1.07004131346946 0.134042279359863 no 484 0.142300356554687 838 719745 SGTC_1129 3453-1384 223 µM 1.06906849279813 0.134260439086256 no 485 0.142519403788781 775 1084452 SGTC_1180 1193-0155 285 µM 1.0656699410578 0.135024494101584 no 486 0.143286435137453 696 2921347 SGTC_1119 parthenolide 318.541 nM 1.06547893189912 0.135067524699193 no 487 0.14332962727188 809 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.06485334138016 0.135208523744064 no 488 0.143471151093514 717 5711223 A potent inhibitor of glutathione S-transferases. SGTC_482 fipronil 114 µM 1.06237266873817 0.135768624692186 no 489 0.14403326820813 699 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2376 9072922 81.32 µM 1.0615523434829 0.135954191720299 no 490 0.144219479164037 754 17087968 SGTC_454 lyso-paf C-16 6.67 µM 1.0592904814395 0.136466750170277 no 491 0.144733754283109 721 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3185 9108267 49.47 µM 1.05761635509831 0.136846972536449 no 492 0.145115191543588 723 4910486 SGTC_2404 5161160 200 µM 1.05679644715141 0.137033451387991 no 493 0.145302248071015 783 2831543 SGTC_3115 9123671 49.47 µM 1.05479948881049 0.1374883633083 no 494 0.145758519231802 779 3286988 SGTC_659 k018-0002 107 µM 1.052352315457 0.138047239723737 no 495 0.146318968825594 769 6797879 YHR007C ERG11 SGTC_2309 7664088 163.95 µM 1.05104905530546 0.138345504875018 no 496 0.146618030111361 815 704922 SGTC_1960 st011366 51.8 µM 1.04929994377048 0.138746497839666 no 497 0.147020045948562 745 3972846 SGTC_509 pifithrin 175 µM 1.04911411485676 0.138789146562806 no 498 0.147062800266877 786 4817 A p53 inhibitor. SGTC_606 k015-0008 38.6 µM 1.04842195723749 0.138948078970199 no 499 0.147222120779401 832 1970475 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.04752068932209 0.139155212693115 no 500 0.147429747548742 746 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2987 9018338 71.43 µM 1.04168739532341 0.140500929138524 no 501 0.148778317374576 769 5055682 SGTC_2414 st077232 92.9 µM 1.03866907960687 0.141200699088232 no 502 0.149479333128372 700 729801 SGTC_2221 6807166 181.081 µM 1.03844261779792 0.141253297397201 no 503 0.149532018543177 694 674925 SGTC_1436 4092-1007 8.32 µM 1.03769790970128 0.141426357900966 no 504 0.149705359214635 741 2881121 SGTC_2205 7238770 200 µM 1.03764995894423 0.141437505956925 no 505 0.14971652498029 752 279867 SGTC_2070 5230947 200 µM 1.03345335066448 0.142415481258491 no 506 0.15069589529643 809 2835538 SGTC_2830 7992007 71.43 µM 1.03160623312111 0.142847378894495 no 507 0.151128309619134 730 1952075 SGTC_173 1273-0061 2.693 µM 1.03030256929089 0.14315273719536 no 508 0.151433996677295 763 2847414 YPL266W DIM1 SGTC_665 3914-0008 307 µM 1.02535126781753 0.144316500203021 no 509 0.152598736697063 747 1069549 SGTC_2138 5575593 77.673 µM 1.02297535107635 0.144877197996725 no 510 0.153159750143745 750 762213 SGTC_3241 9133421 49.47 µM 1.01085846047306 0.147759483385926 no 511 0.156042089023866 789 17018221 SGTC_225 nsc-122657 1.016 µM 1.0087749471044 0.148258938298682 no 512 0.156541289339844 664 275685 SGTC_537 1334-0398 209 µM 1.00811093676693 0.148418350349043 no 513 0.156700603898052 821 5846986 SGTC_2056 5235370 200 µM 1.00326054742464 0.149586282109465 no 514 0.157867583122405 758 5511916 SGTC_2511 berberine 10.47 µM 1.00187641896752 0.149920690006335 no 515 0.158201641457321 790 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2864 9034755 47.6 µM 1.00124548642375 0.150073289728073 no 516 0.158354070355976 831 4930451 SGTC_2686 alizarin 95.37 µM 0.997340398029092 0.151020092481082 no 517 0.159299655534141 732 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2697 mebhydrolin 72.4 µM 0.996734970916163 0.151167235603621 no 518 0.159446585136317 832 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_500 h-89 112 µM 0.996648238535594 0.151188322866167 no 519 0.159467641265318 863 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1390 3413-2614 145 µM 0.995310088264574 0.151513915634731 no 520 0.159792736368206 820 3421432 SGTC_2353 9059630 146.67 µM 0.993808401214449 0.15187985416061 no 521 0.160158077628065 815 4779114 SGTC_1756 st041558 35.5 µM 0.993241262425212 0.15201820997544 no 522 0.160296197193036 894 3955792 SGTC_2141 5621638 7.665 µM 0.991734838196712 0.152386114664432 no 523 0.160663445887922 813 2856238 SGTC_3152 9099253 49.47 µM 0.989499210696022 0.152933196596499 no 524 0.161209477923323 883 25236131 SGTC_1861 st057647 17.4 µM 0.989350462184718 0.152969643093734 no 525 0.161245851323737 815 688668 SGTC_992 3909-8734 162 µM 0.987622441417178 0.153393466331013 no 526 0.161668795711246 791 4288319 SGTC_3279 9140807 49.47 µM 0.986177052018394 0.153748566823761 no 527 0.162023119075264 825 45595718 SGTC_2432 5630864 12.22 µM 0.984982698431737 0.154042403613401 no 528 0.162316284783483 782 5714970 SGTC_781 4335-2806 94.4 µM 0.984461241599509 0.154170809702784 no 529 0.162444389660763 906 845254 SGTC_148 3253-0744 288.01 µM 0.983906189831951 0.154307566138641 no 530 0.162580819987507 815 6893655 SGTC_137 0438-0332 85.389 µM 0.983290733585399 0.154459299091627 no 531 0.162732184717749 881 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_941 3237-0776 460 µM 0.98088526011965 0.155053283951793 no 532 0.163324663505957 796 760008 SGTC_2762 leflunomide 42.06 µM 0.98028446458857 0.155201873804844 no 533 0.163472860553746 848 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_105 0111-0055 734.78 µM 0.977109601477192 0.155988647122291 no 534 0.164257447427462 726 5179370 SGTC_2119 5528445 120.635 µM 0.976029931576923 0.156256801637447 no 535 0.164524815921825 831 791935 SGTC_2229 7354935 190 µM 0.974163451569937 0.156721089767751 no 536 0.164987694267618 780 318112 SGTC_808 0711-0032 135 µM 0.967149235451912 0.158473990070601 no 537 0.166734717698753 851 4252555 SGTC_47 0149-0135 24.25 µM 0.966425198624766 0.15865566122265 no 538 0.166915729994483 856 5239155 SGTC_2761 levamisole 97.89 µM 0.966338839335743 0.158677339109722 no 539 0.166937328642834 825 26879 An alkaline phosphatase inhibitor. SGTC_2893 9048488 25.97 µM 0.96525324961011 0.15895000920722 no 540 0.167208990768197 811 6467338 SGTC_2889 9059656 51.95 µM 0.96369697129173 0.159341438532597 no 541 0.167598936623532 878 3949838 SGTC_2222 6885208 172.143 µM 0.963419654580998 0.159411254398883 no 542 0.16766848338606 822 609514 SGTC_2219 9098279 200 µM 0.96020036252627 0.160223192732338 no 543 0.168477192220063 841 902349 SGTC_3267 9137951 49.47 µM 0.958099372577282 0.160754539060443 no 544 0.1690063259168 830 16643986 SGTC_3234 9132280 49.47 µM 0.957856273513325 0.16081609368879 no 545 0.169067619168029 830 17612295 SGTC_2095 5432005 200 µM 0.956970480086115 0.161040513849099 no 546 0.169291077519169 803 783734 SGTC_978 1416-0512 87.4 µM 0.9568405791758 0.161073442065172 no 547 0.169323863443987 860 6814003 SGTC_2263 7948595 193.29 µM 0.956493249117425 0.161161507361835 no 548 0.169411546719386 787 2971371 SGTC_1109 tnp00067 928.257 nM 0.954917824016528 0.161561349634006 no 549 0.169809627655508 847 676295 SGTC_2214 7179297 48.276 µM 0.951818890247175 0.162349743404514 no 550 0.170594420039724 866 769744 SGTC_870 0573-2213 57.6 µM 0.951244341277951 0.162496188026072 no 551 0.170740177001495 822 3916321 SGTC_2648 atorvastatin 78.68 µM 0.950782752382449 0.162613902931331 no 552 0.170857334918318 836 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1061 3448-9325 110 µM 0.950381593990412 0.16271625183062 no 553 0.170959196471963 846 723482 SGTC_829 1635-0120 117 µM 0.945842282706847 0.163877300446753 no 554 0.172114517852805 902 285054 SGTC_104 0074-0074 590.992 µM 0.944999346612969 0.164093494014985 no 555 0.172329604800101 715 3943124 SGTC_1370 2001-0092 44.6 µM 0.943655257714168 0.164438604172243 no 556 0.172672922444532 965 790957 SGTC_156 3474-0145 5.642 µM 0.943311613697609 0.164526914160702 no 557 0.172760768617946 854 2265471 SGTC_2271 7849410 118.62 µM 0.939555667409846 0.165494124439781 no 558 0.173722762691424 861 972430 SGTC_2326 6164455 177.58 µM 0.938490958588737 0.16576897002981 no 559 0.173996080623349 806 2888790 SGTC_2947 9072639 7.68 µM 0.938379310551467 0.165797808112606 no 560 0.174024757256484 948 16488146 SGTC_3229 9132204 49.47 µM 0.937168723209224 0.166110704472952 no 561 0.174335887723934 872 17682924 SGTC_850 0388-0143 75.9 µM 0.937103681833272 0.166127526286451 no 562 0.17435261386713 810 67273 SGTC_1886 st057356 49.9 µM 0.934753138899825 0.166736191566842 no 563 0.174957767315498 818 24207747 SGTC_1406 3909-7906 11.9 µM 0.933887266391772 0.166960768575575 no 564 0.175181023968653 885 X1406 SGTC_3146 9095609 49.47 µM 0.932171653387818 0.167406314433933 no 565 0.175623911207081 857 17173999 SGTC_2776 terbinafine 19.92 µM 0.930734549472361 0.167780120413146 no 566 0.175995446630847 854 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_562 3772-2733 112 µM 0.93050682212458 0.167839404005237 no 567 0.176054366779018 940 2876874 YIL048W NEO1 SGTC_2274 7947094 46.08 µM 0.928709176875409 0.16830785304558 no 568 0.176519911808065 950 2971028 SGTC_2459 5811157 9.22 µM 0.92825368882873 0.168426682254182 no 569 0.176637995314306 910 2870684 YBR192W RIM2 SGTC_1059 3448-6867 171 µM 0.927187299936507 0.168705096219937 no 570 0.176914647800201 899 3934407 SGTC_2280 7785178 200 µM 0.926813038410982 0.168802878904146 no 571 0.177011807073852 860 2954328 SGTC_1856 st057054 55.7 µM 0.92616692258767 0.168971774192423 no 572 0.177179619761536 922 1266018 SGTC_2015 5119600 184 µM 0.924318803581671 0.169455473305159 no 573 0.177660177755317 895 2828786 SGTC_628 1636-0253 16 µM 0.921529209030251 0.170187261211413 no 574 0.178387099332736 889 4456143 SGTC_2408 sulbentine 18.36 µM 0.920983497427078 0.170330652936959 no 575 0.178529521473192 856 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.918047930533099 0.171103332810166 no 576 0.179296886574598 920 688798 SGTC_590 k048-0076 22.4 µM 0.917715907211615 0.171190866619971 no 577 0.179383808740156 882 6832814 SGTC_729 4092-0585 94.1 µM 0.917368656892785 0.17128244546742 no 578 0.179474745602572 829 2169061 SGTC_734 2023-0417 80 µM 0.91439795325671 0.172067176235594 no 579 0.180253888457509 879 3935732 SGTC_1227 3909-8010 46.6 µM 0.913474428386844 0.172311598233337 no 580 0.180496538320153 863 15982272 SGTC_2286 7945697 125 µM 0.909893195853881 0.173261508280341 no 581 0.181439419236573 881 1245733 SGTC_354 2783-3500 4.88 µM 0.909679235378946 0.173318365948885 no 582 0.181495849030988 857 6740761 SGTC_969 1313-0238 134 µM 0.901751350284777 0.175433486239985 no 583 0.183594484178468 930 5212874 SGTC_1615 st002656 86.5 µM 0.90042091944958 0.175790035324559 no 584 0.183948146104885 886 1584458 SGTC_2824 7998404 51.95 µM 0.899638089357202 0.176000044388803 no 585 0.184156440113438 853 837851 SGTC_330 1488-0319 80.1 µM 0.899100630914012 0.176144319772262 no 586 0.184299531040753 894 6846614 SGTC_2751 anetholtrithion 17.25 µM 0.899060921212432 0.176154982416514 no 587 0.184310105947175 886 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1933 st074711 15.9 µM 0.897870722398522 0.176474758079928 no 588 0.184627237500214 976 17250958 SGTC_2124 5246320 200 µM 0.897843588977406 0.176482052407275 no 589 0.184634471224003 880 579342 SGTC_1291 0993-0025 5.79 µM 0.895377956904606 0.177145688745507 no 590 0.185292540001306 939 4353356 SGTC_1228 0124-0032 52.5 µM 0.893564069383971 0.177634910043822 no 591 0.185777588976295 958 X1228 SGTC_1204 4049-0315 18.3 µM 0.893123266615302 0.177753927045134 no 592 0.185895582241631 888 588402 SGTC_1444 4112-3581 28 µM 0.891548726064242 0.178179464557764 no 593 0.1863174316827 948 2877249 SGTC_2640 pentamidine 10.38 µM 0.889152990461837 0.178828170019467 no 594 0.186960431664149 980 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2278 7948257 134.34 µM 0.88703089578092 0.179404020320387 no 595 0.187531133397243 940 1247028 SGTC_947 3447-0010 211 µM 0.88680503041061 0.179465379578494 no 596 0.187591939420141 908 748350 SGTC_2291 7917025 104.35 µM 0.885983060585238 0.179688789689213 no 597 0.187813327669455 879 2964612 SGTC_3356 9151811 4.48 µM 0.885080495872758 0.179934306558726 no 598 0.188056609017763 905 1859254 YPR165W RHO1 SGTC_191 3914-0123 66.505 µM 0.880604055217877 0.181155105235366 no 599 0.189266081470229 802 3144412 SGTC_2563 tomatine 8.54 µM 0.880072503483596 0.18130041193274 no 600 0.189410016821681 951 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1795 st049545 62.3 µM 0.880054020484571 0.18130546581769 no 601 0.189415022921497 948 5291882 SGTC_341 1486-1430 230 µM 0.879845080953161 0.18136260317672 no 602 0.189471619625321 929 2054753 YPL210C SRP72 SGTC_1399 3562-5772 25 µM 0.879387429689047 0.181487793531688 no 603 0.189595622723241 852 23847490 SGTC_40 0327-0103 19.753 µM 0.877853969262417 0.181907665287673 no 604 0.190011485962732 898 409036 SGTC_2982 9019404 25.97 µM 0.876849875575449 0.182182921729599 no 605 0.190284092327903 869 22333232 SGTC_1628 st004252 77.7 µM 0.876308396551748 0.1823314676528 no 606 0.190431200811959 946 692968 SGTC_2905 7799065 20.05 µM 0.871574428555043 0.183633375636494 no 607 0.191720292948758 914 1296806 SGTC_1913 st060213 96.1 µM 0.869907855661217 0.184093081887889 no 608 0.192175381040298 992 688959 SGTC_2846 9008642 19.48 µM 0.869689043291985 0.184153492092758 no 609 0.192235180785257 892 2992898 SGTC_2984 9022109 38.96 µM 0.867468836979063 0.184767149164557 no 610 0.192842589641468 935 6459207 SGTC_2720 fluspirilene 36.88 µM 0.862483119511086 0.186149809147484 no 611 0.194210859141768 883 3396 An atypical antipsychotic. SGTC_1448 4255-0083 152 µM 0.861542333261383 0.186411429319539 no 612 0.194469708030074 1014 5399660 SGTC_3171 9103192 49.47 µM 0.861379376008484 0.186456768700848 no 613 0.194514565583011 1011 13018434 SGTC_737 1950-0117 57.9 µM 0.858645202944337 0.18721851247904 no 614 0.195268145544598 978 5393513 SGTC_1791 st048313 56.1 µM 0.858141293766494 0.187359111884597 no 615 0.195407223976008 913 1204976 SGTC_2401 5128683 200 µM 0.857039923989437 0.187666640330374 no 616 0.19571141034309 909 708373 SGTC_2778 tioconazole 65.09 nM 0.856322893745808 0.187867019598237 no 617 0.19590960069922 918 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_209 4077-0173 175.592 µM 0.855711608088418 0.188037952066636 no 618 0.196078658905247 864 15993494 SGTC_67 0335-0847 266 µM 0.855139176490261 0.188198106873164 no 619 0.196237051766629 1040 4552207 YOR254C SEC63 SGTC_377 3970-0964 33.1 µM 0.852690644265403 0.188884106347099 no 620 0.196915440240506 1045 16481235 SGTC_1078 idebenone 36.1 µM 0.850177264687292 0.189589874172434 no 621 0.19761326993125 994 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_229 benomyl 22.8748 µM 0.849858520898751 0.189679494580939 no 622 0.197701874539308 961 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2836 9010338 19.48 µM 0.849177642275784 0.189871022817217 no 623 0.197891226031077 944 2994051 SGTC_257 daunorubicin 18.5 µM 0.848065349875223 0.190184161577612 no 624 0.198200788720099 987 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2954 9074818 52.69 µM 0.848002905033717 0.190201750799644 no 625 0.198218176439183 941 16648742 SGTC_3247 9135149 49.47 µM 0.847028120490411 0.190476453911621 no 626 0.198489723822629 920 8934436 YOR116C RPO31 SGTC_1426 4048-4480 71.7 µM 0.846532007065571 0.190616356664894 no 627 0.19862801311402 994 14224343 SGTC_511 blebbistatin 171 µM 0.84608314480996 0.190742989042488 no 628 0.198753181418582 972 3476986 A myosin inhibitor. SGTC_2529 gangaleoidin 93.61 µM 0.843957228313832 0.191343450569916 no 629 0.199346653478283 981 4565183 SGTC_345 1362-0200 395 µM 0.84264957011922 0.191713371223141 no 630 0.199712229522702 942 1419823 SGTC_761 k216-0224 480 µM 0.842433353019985 0.191774578586279 no 631 0.199772715188074 1047 1340404 SGTC_585 0kpi-0023 191 µM 0.842292514246695 0.191814454068975 no 632 0.199812120065251 960 64601 SGTC_73 0327-0325 16.231 µM 0.840054752866828 0.19244870918857 no 633 0.200438843986094 1063 53298 SGTC_667 1498-1044 59 µM 0.839762093425731 0.192531753202202 no 634 0.200520895560198 1011 6739982 SGTC_299 1273-0059 1.44 µM 0.839713576362264 0.192545522349913 no 635 0.200534500013818 956 2848077 SGTC_1742 st038235 28.8875 µM 0.836249072796566 0.193530304395416 no 636 0.201507398355989 954 564103 YBR002C RER2 SGTC_3088 9117578 49.47 µM 0.835256574239252 0.193812986351022 no 637 0.201786631094525 1022 678341 SGTC_2593 nobiletin 86.24 µM 0.834816221784961 0.193938487446551 no 638 0.201910595442767 927 72344 An anti-infammatory. SGTC_1032 k061-1018 98.7 µM 0.834105570728477 0.19414112846369 no 639 0.202110748127217 1072 4005393 SGTC_3338 9144300 39.5675 µM 0.834043922136312 0.19415871353901 no 640 0.202128116858187 985 4901274 SGTC_2360 9040895 200 µM 0.83371803201039 0.194251688835715 no 641 0.202219947222695 929 4914414 SGTC_1079 idarubicin 2.36 µM 0.832497128205004 0.194600249352673 no 642 0.202564199246102 974 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3326 9140064 16.379 µM 0.83170455802264 0.194826726854245 no 643 0.202787863623307 1026 1868434 SGTC_2992 9074591 71.4286 µM 0.828497414118946 0.195744806208716 no 644 0.203694429392484 964 17741321 SGTC_1706 st031321 9.9705 µM 0.828451279210467 0.195758031951218 no 645 0.203707487986894 1033 6103185 SGTC_2085 5307070 144.047 µM 0.827995656474681 0.195888676899564 no 646 0.203836479877778 950 2840351 SGTC_1875 nocodazole 6 µM 0.826805199438554 0.19623027734542 no 647 0.204173741275447 1016 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_940 3232-1287 54.8 µM 0.826641125845528 0.196277386401867 no 648 0.204220250047345 1011 1585493 YIL048W NEO1 SGTC_930 2810-3379 265 µM 0.826495622631145 0.196319169239145 no 649 0.204261500084199 1057 1015764 SGTC_505 gw-5074 63.9 µM 0.825948181921231 0.196476421118829 no 650 0.204416743500116 1010 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_773 4358-1457 44.6 µM 0.825441769953382 0.196621955469769 no 651 0.204560414486769 1048 1186886 SGTC_1089 terbinafine 2.25 µM 0.825082853582014 0.196725141580507 no 652 0.204662276790311 994 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2371 9071574 200 µM 0.823939699249118 0.197054009498691 no 653 0.204986910891624 987 45596039 SGTC_2232 chlorophetanol 41.5365 µM 0.823609255585178 0.197149135014135 no 654 0.205080807611942 1107 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1319 1306-0155 43.7 µM 0.822697751248696 0.19741167568984 no 655 0.205339947224779 1027 3122360 SGTC_456 gingerol 170 µM 0.822043172992973 0.19760034429303 no 656 0.205526162987565 1075 442793 A herb. SGTC_2728 chlorpromazine 9.18 µM 0.820622258701884 0.198010268284799 no 657 0.205930732485917 962 2726 A thorazine and dopamine antagonist. SGTC_865 0488-0499 301 µM 0.81888685247817 0.198511617096803 no 658 0.206425485887399 1066 9634651 SGTC_1127 asiatic acid 681.4 nM 0.816776227913786 0.199122395240531 no 659 0.207028159860674 955 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1631 benzylvanillin 81.9 µM 0.815983019482739 0.199352228370663 no 660 0.207254923817522 986 75506 SGTC_547 1120-0019 610 nM 0.814224097098489 0.199862447804173 no 661 0.207758291628285 987 3676939 SGTC_2351 9026858 72.31 µM 0.813716650024749 0.20000979136699 no 662 0.20790364676925 977 1409300 SGTC_2137 5261020 140 µM 0.813547536598732 0.200058910056936 no 663 0.207952101623509 996 763655 SGTC_909 3448-9333 149 µM 0.812812964041853 0.200272349477465 no 664 0.208162650785436 952 3344074 SGTC_1151 3909-8316 15.3 µM 0.811786029564339 0.200570967626203 no 665 0.208457209874102 1007 800431 SGTC_2730 imipramine 71.33 µM 0.808772290436432 0.201448863054063 no 666 0.209323068806992 1095 3696 A tricyclic antidepressant. SGTC_408 cantharidin 100 µM 0.808409794473442 0.201554612237828 no 667 0.209427357720864 1010 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1318 1280-3875 124 µM 0.808258138305956 0.201598864019942 no 668 0.209470997777919 1011 373245 SGTC_1294 1000-1494 117 µM 0.807563271779458 0.20180169367347 no 669 0.209671018582704 1007 712797 YDL207W GLE1 SGTC_2835 9006588 71.43 µM 0.807442787087658 0.201836875254758 no 670 0.209705712126128 960 2345538 SGTC_129 0088-0017 176.636 µM 0.806303961934347 0.202169594052905 no 671 0.210033803310017 987 182446 SGTC_3300 9124615 50.48 µM 0.804406617667426 0.202724649791704 no 672 0.210581090272207 1024 24824903 SGTC_2024 5144227 134 µM 0.803848492509983 0.202888098848458 no 673 0.210742240034551 1048 3475211 SGTC_1847 st056231 15 µM 0.802550137943419 0.203268631300673 no 674 0.211117399019355 1106 5393180 SGTC_796 1234-0020 70.7 µM 0.801748154526058 0.203503895873358 no 675 0.211349327201004 1049 46495034 SGTC_620 0109-0052 432 µM 0.801523324955167 0.203569879533163 no 676 0.211414373166985 1056 493037 SGTC_2439 5492030 7.2 µM 0.800827965421082 0.203774036486485 no 677 0.211615623441308 1011 5722370 SGTC_741 4582-0002 126 µM 0.800424354622182 0.20389259222675 no 678 0.211732487501999 1012 2912688 SGTC_3039 9090270 49.47 µM 0.799253321245436 0.204236801546136 no 679 0.212071769708573 1040 17173750 SGTC_1004 4084-0029 199 µM 0.798986899412868 0.204315160908208 no 680 0.212149004180101 1068 716894 YLR208W SEC13 SGTC_3339 9145883 14.936 µM 0.798770484987502 0.204378825382754 no 681 0.212211753835671 970 2030670 SGTC_1902 st060212 70.5 µM 0.797357240031551 0.204794861965046 no 682 0.21262179280351 1095 688944 SGTC_1023 4482-3888 16 µM 0.795440431868757 0.205359943580205 no 683 0.213178674333516 1052 3303168 SGTC_375 3970-0961 9.27 µM 0.794530523350131 0.205628511565757 no 684 0.213443323371903 1033 2898222 SGTC_1260 0700-1617 7.75 µM 0.793871199393566 0.205823247385063 no 685 0.213635208894518 1024 2853078 SGTC_1579 chlormadinone acetate 49.4 µM 0.793508265761523 0.205930488982142 no 686 0.213740877703014 1072 45114258 A steroidal progestin. SGTC_221 trifluoperazine 10.304 µM 0.792920228834976 0.206104315660593 no 687 0.213912150362502 1133 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2197 6588183 93.1375 µM 0.792407832930734 0.206255853382104 no 688 0.214061456812695 1029 884136 SGTC_555 4296-0685 37 µM 0.79169750101585 0.206466038578121 no 689 0.214268539898178 1059 2908540 YHR072W ERG7 SGTC_2189 6047310 154.431 µM 0.790987238727077 0.206676329996711 no 690 0.214475719158082 1034 711535 SGTC_3070 9117005 49.47 µM 0.790172004850256 0.206917857222884 no 691 0.214713661509813 1037 8779016 SGTC_842 0271-0008 11.1 µM 0.788890691689697 0.207297805967742 no 692 0.215087948293097 1076 1221709 SGTC_3329 9141233 27.5565 µM 0.788669658200656 0.207363390888752 no 693 0.215152553086414 1046 4909101 YNL103W MET4 SGTC_3167 9103034 49.47 µM 0.786050191734907 0.208141571095241 no 694 0.215919041413545 1053 5127859 SGTC_2611 pyromycin 23.93 µM 0.783098194849614 0.209020600280205 no 695 0.216784725568953 1054 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_3121 9125696 49.47 µM 0.779347104132779 0.210140727592954 no 696 0.217887637045208 1122 1235365 SGTC_2304 7443016 91.4 µM 0.779295148417299 0.210156267001356 no 697 0.217902935969041 997 939854 SGTC_2513 baicalein 25.65 µM 0.777731116342471 0.210624368463308 no 698 0.218363772096125 1075 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_226 1,3-diallylurea 8.28947 mM 0.777212293271759 0.210779782808959 no 699 0.218516765262671 1053 74537 YKL182W FAS1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.77686716326078 0.210883204342368 no 700 0.218618573119951 1120 6710655 SGTC_3066 9117245 49.47 µM 0.776077097878225 0.211120067042596 no 701 0.218851732598438 1111 17176980 SGTC_213 1246-0773 967 nM 0.77606120005942 0.211124834830495 no 702 0.218856425737755 1067 6251622 SGTC_1950 st077106 7.18 µM 0.775939353008543 0.211161379101779 no 703 0.218892397700732 1019 13831864 SGTC_869 0564-0080 44.1 µM 0.775900422035429 0.211173056029831 no 704 0.218903891707957 1033 6843321 SGTC_1923 st058458 19.1 µM 0.774993404596093 0.211445213272629 no 705 0.21917177841946 1118 3534982 SGTC_556 4058-0063 51.5 µM 0.77475434546486 0.211516978909232 no 706 0.219242415670261 1123 6615692 SGTC_1564 D-Arginine 115 µM 0.774696065535863 0.211534476726741 no 707 0.219259638221743 1065 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2075 5212009 200 µM 0.7736857292535 0.211837952194422 no 708 0.219558330592739 991 780898 SGTC_1990 st072050 59.8 µM 0.773563204177485 0.211874772454369 no 709 0.219594569371066 1118 17233948 SGTC_3305 9127027 53.8275 µM 0.773372265128138 0.211932159399622 no 710 0.219651049538726 1048 41905295 SGTC_643 k048-0106 28.4 µM 0.772838220703439 0.212092715319788 no 711 0.219809065276072 1070 6763920 SGTC_3255 9139072 49.47 µM 0.771101276023927 0.212615404575688 no 712 0.220323452166407 1126 17646060 SGTC_1364 1653-0028 37.6 µM 0.770922248497437 0.212669321080605 no 713 0.220376509413835 1039 5718652 SGTC_2118 5526350 200 µM 0.768816274667007 0.213304162023991 no 714 0.221001193036592 1074 743594 SGTC_2111 5486399 200 µM 0.76815516406023 0.213503679930562 no 715 0.221197503512611 1124 689674 SGTC_481 bay k-8644 50 µM 0.765605523324267 0.214274158984143 no 716 0.221955528511245 1038 2303 A calcium channel antagonist. SGTC_396 dithiazanine 1.25 µM 0.765438320751246 0.214324742583252 no 717 0.222005290710723 1050 10578 An antihelmenthic. SGTC_2261 9010538 184.68 µM 0.76408565267468 0.214734218981071 no 718 0.222408100821198 1022 6457250 SGTC_1764 st044502 93.5 µM 0.763448500638345 0.214927253484734 no 719 0.222597982225371 1092 8407 SGTC_508 roscovitine 141 µM 0.762596434216883 0.215185556883941 no 720 0.222852055903038 1111 160355 A CDKinase inhibitor. SGTC_3061 glucosamine 200 µM 0.761095085142516 0.215641128107469 no 721 0.223300137930387 1066 91431 and experimental redox chemotherapeutic SGTC_1860 st056228 74.6 µM 0.76050907662766 0.215819098884621 no 722 0.223475172917022 1101 688679 SGTC_2684 capsaicin 100 µM 0.758497439770483 0.216430680270746 no 723 0.224076622565684 1082 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2218 6965428 192.983 µM 0.758247546524712 0.21650672322851 no 724 0.224151401099017 1094 675684 SGTC_109 0132-0036 33.701 µM 0.757963070059952 0.216593308734663 no 725 0.224236545628666 989 67274 A color developer. SGTC_1792 st045773 43.6 µM 0.757914965608588 0.216607952165641 no 726 0.224250945228346 1065 2919270 SGTC_924 2046-0044 21.3 µM 0.757471224749922 0.216743057909481 no 727 0.224383799495323 1134 3623589 SGTC_497 capsazepine 133 µM 0.757444247036805 0.216751273382764 no 728 0.224391877956782 1101 2733484 A calcium channel blocker. SGTC_2811 7967822 32.47 µM 0.753853827925602 0.217846262867703 no 729 0.225468498966896 1093 2232244 SGTC_2568 diosmetin 100 µM 0.752681669300271 0.218204432027929 no 730 0.225820613886444 1119 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1176 0848-0131 83.3 µM 0.750413518212371 0.218898459494422 no 731 0.226502845875932 1177 6769040 SGTC_3092 9117248 49.47 µM 0.749448717905734 0.219194061549497 no 732 0.226793398367171 1163 17141857 SGTC_1299 1079-1439 3.74 µM 0.747916922572035 0.219663854461989 no 733 0.227255134777734 1106 323161 SGTC_2253 7938677 135.83 µM 0.747897307799705 0.21966987394784 no 734 0.227261050785827 1110 2301972 SGTC_1979 st071809 45.3 µM 0.747392411862667 0.219824851697983 no 735 0.227413362228063 1121 4976333 SGTC_698 k064-0052 127 µM 0.746695634801115 0.220038830369793 no 736 0.227623652658379 1145 5088751 SGTC_521 r062-0005 13.8 µM 0.746051807583492 0.220236654437573 no 737 0.227818059869929 1065 2832033 SGTC_1050 3232-1156 69.3 µM 0.744364531105465 0.220755575076532 no 738 0.228327985434237 1074 700529 SGTC_2301 7769476 200 µM 0.743890674886884 0.220901435047133 no 739 0.228471308668255 1094 977820 SGTC_344 k064-0035 6.43 µM 0.742657409145004 0.221281311076797 no 740 0.228844560853949 1097 5088750 SGTC_935 2996-0153 430 µM 0.742578720701442 0.22130556171687 no 741 0.228868387796361 1141 23738523 SGTC_1900 st060200 72.8 µM 0.742445981065462 0.221346473597067 no 742 0.228908584651259 1137 688945 SGTC_541 4513-1321 94 µM 0.741758359451485 0.221558475696836 no 743 0.229116876944527 1087 747515 SGTC_1002 4049-0206 172 µM 0.74100197247474 0.221791812984162 no 744 0.229346122173632 1170 4662749 SGTC_2540 epiandrosterone 100 µM 0.740680263270345 0.221891099364974 no 745 0.229443664532097 1228 441302 A steroid. SGTC_2875 9039966 71.43 µM 0.740150578135196 0.222054626880483 no 746 0.229604315917505 1157 6463691 SGTC_3169 9102970 49.47 µM 0.740010296647601 0.222097946928003 no 747 0.229646873284151 1169 17027839 SGTC_2612 dictamnine 15.46 µM 0.738889946901071 0.222444092970203 no 748 0.229986913669511 1068 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_650 1328-0195 38 µM 0.737221299003698 0.222960212519088 no 749 0.230493891511195 1122 2780821 SGTC_1295 1013-0063 9.78 µM 0.735850500986645 0.223384715750551 no 750 0.23091084188557 1145 6826038 SGTC_2049 5262831 67.185 µM 0.734833813905901 0.223699856133203 no 751 0.231220355494827 1141 763417 SGTC_718 1130-0073 349 µM 0.734658457910689 0.223754236414008 no 752 0.231273763128587 1176 6740020 SGTC_3129 9127257 49.47 µM 0.730656478606534 0.224997345788064 no 753 0.232494502527147 1069 837894 SGTC_1188 1403-0014 4.57 µM 0.729898505287969 0.22523323030104 no 754 0.23272611301598 1176 9614867 SGTC_1400 3771-8998 51.5 µM 0.729579295167155 0.225332611744877 no 755 0.232823690971803 1096 670767 SGTC_2215 7188065 200 µM 0.72936688332148 0.225398756850669 no 756 0.232888634820501 1149 940217 SGTC_1545 lovastatin 49.4 µM 0.729021483341006 0.225506337964997 no 757 0.232994260603129 1189 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2114 5491910 81.25 µM 0.728974845823948 0.225520866295791 no 758 0.233008524727633 1157 2849228 SGTC_2826 7992541 19.48 µM 0.728820661802818 0.225568900849401 no 759 0.233055685494194 1213 2985066 SGTC_2922 7999257 32.47 µM 0.728364322210287 0.225711102997514 no 760 0.233195298619375 1116 2988377 SGTC_927 2425-1185 123 µM 0.72729912305147 0.226043232042719 no 761 0.233521367614537 1151 730375 SGTC_1884 5633444 25 µM 0.726405242161056 0.226322157110449 no 762 0.233795189252342 1132 5724239 SGTC_646 4092-0839 27.3 µM 0.725096964251897 0.226730740196017 no 763 0.234196273331631 1182 877796 SGTC_355 1311-2252 105 µM 0.723561536912209 0.227210793879207 no 764 0.234667481047409 1137 5338538 SGTC_2293 7624732 200 µM 0.722730727670628 0.22747078630412 no 765 0.234922666744599 1154 894453 SGTC_979 1426-2828 121 µM 0.722416428349676 0.227569186416556 no 766 0.235019244743468 1198 747872 SGTC_1581 himbacine 57.9 µM 0.721883274555797 0.227736159788838 no 767 0.235183122568939 1130 5281825 An alkaloid muscarinic receptor antagonist. SGTC_501 nsc-95397 161 µM 0.721586463083981 0.227829145226522 no 768 0.235274382152915 1151 262093 SGTC_469 w7 172 µM 0.720677274847151 0.228114109672879 no 769 0.235554048707772 1195 45115570 A P450 inhibitor. SGTC_601 0986-0029 62.9 µM 0.72033825853041 0.228220417932718 no 770 0.235658377145889 1145 24747981 SGTC_1104 tacrolimus 29.8 µM 0.719222109641163 0.228570615055091 no 771 0.23600203935766 1207 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3232 9132874 49.47 µM 0.717531291930697 0.229101691780509 no 772 0.236523167731475 1144 3784940 SGTC_2456 5770359 74.46 µM 0.717381322031761 0.229148829911787 no 773 0.236569420637285 1169 3118787 SGTC_2798 7813637 45.45 µM 0.717365920874002 0.229153671069835 no 774 0.236574170860912 1138 956368 SGTC_38 0929-0051 58.268 µM 0.715649512761465 0.22969356142232 no 775 0.23710389629982 1173 1379719 SGTC_622 1348-1566 26.3 µM 0.715411458998634 0.229768496641214 no 776 0.237177416931499 1197 7340407 SGTC_2250 alverine citrate 130 µM 0.714787998854328 0.229964816002975 no 777 0.237370025981777 1130 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_1199 1638-0010 4.46 µM 0.714690335434783 0.229995577426252 no 778 0.237400205470156 1161 3111136 SGTC_610 4215-0184 155 µM 0.713682567011361 0.230313132575583 no 779 0.237711744300381 1176 5605015 SGTC_1351 1496-0003 46.5 µM 0.712764321731693 0.230602691683401 no 780 0.23799580335429 1189 3891978 SGTC_845 0330-0138 4.51 µM 0.712359491816067 0.230730415173803 no 781 0.238121096511033 1146 9039800 SGTC_2956 9076196 2.52 µM 0.712060038708172 0.230824917792529 no 782 0.238213799241537 1180 16423868 SGTC_2656 pseudo-anisatin 100 µM 0.711643617385357 0.230956369635126 no 783 0.238342745084426 1190 6708809 A neurotoxin. SGTC_2355 9061122 103.12 µM 0.711147625880101 0.231112993940989 no 784 0.238496379890421 1155 5302957 SGTC_3243 9134147 49.47 µM 0.710719089890304 0.231248364846418 no 785 0.238629163800151 1226 24282180 SGTC_1378 2093-0007 380 nM 0.710109843384265 0.23144089680393 no 786 0.238818011347083 1174 3618014 SGTC_1073 triclabendazole 3.09 µM 0.709855332910019 0.231521352777435 no 787 0.238896925912671 1219 50248 An antihelmetic and likely tubulin inhibitor. SGTC_290 2043-6722 48.1 µM 0.708469109106283 0.23195984013989 no 788 0.239326994430772 1190 773758 YLR208W SEC13 SGTC_3074 9116018 49.47 µM 0.707646100870882 0.232220390977556 no 789 0.239582528277636 1217 17027303 SGTC_150 3970-0969 77.2 µM 0.70737150762077 0.232307358893386 no 790 0.239667819199548 1172 6615640 SGTC_10 0279-0212 42.575 µM 0.706733116354432 0.23250961726657 no 791 0.239866172807744 1210 39851 YBR002C RER2 SGTC_1650 st011916 45.8 µM 0.706038090024575 0.232729930341456 no 792 0.240082225187261 1169 242528 SGTC_46 0329-0187a 2.197 µM 0.705035249919708 0.233048020199962 no 793 0.240394149885782 1193 46494817 SGTC_3284 9108171 64.8615 µM 0.704997511655207 0.233059995074203 no 794 0.240405892353284 1121 8687505 SGTC_2179 6298986 200 µM 0.704131457461161 0.233334899942337 no 795 0.24067545569069 1128 738374 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.703425696487979 0.23355905716815 no 796 0.240895248632348 1151 688803 SGTC_654 1124-0271 80.9 µM 0.702887958124773 0.233729928744644 no 797 0.241062788079167 1186 5403748 SGTC_977 1348-1378 135 µM 0.702321670437257 0.233909947031802 no 798 0.241239290912374 1195 X977 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.698781479128066 0.23503708479521 no 799 0.242344302381525 1130 1241132 A phosphatase inhibitor. SGTC_1029 k015-0030 64.7 µM 0.695945420082597 0.235942198961749 no 800 0.243231505642523 1176 2208316 SGTC_2882 9058044 58.44 µM 0.695714647215786 0.236015933399463 no 801 0.243303775397437 1156 18076804 SGTC_3172 9105863 49.47 µM 0.6951584476371 0.236193697375389 no 802 0.243478004767296 1170 2348785 SGTC_2102 5377816 72.7585 µM 0.693508688382269 0.236721401620621 no 803 0.243995187627271 1223 1379702 SGTC_586 0957-0265 8.15 µM 0.692360845739892 0.237088941301587 no 804 0.244355374014201 1109 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2850 9015429 58.44 µM 0.692140715551867 0.237159462893866 no 805 0.24442448232732 1202 6457570 SGTC_3135 9127742 49.47 µM 0.691402895936003 0.23739591710687 no 806 0.244656192355442 1175 3643468 SGTC_2759 disulfiram 3.38 µM 0.691376120837465 0.237404500343147 no 807 0.244664603218043 1167 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_937 3122-0005 46.7 µM 0.691261512552396 0.237441242002305 no 808 0.244700606882025 1196 759535 SGTC_3303 9125618 40.5795 µM 0.691211022048972 0.237457429474141 no 809 0.244716469145877 1225 22695467 SGTC_1730 st033808 45.1 µM 0.691143552732961 0.237479061371695 no 810 0.244737666393885 1206 1045166 SGTC_2753 fluvastatin 17.09 µM 0.689672212953187 0.23795106874577 no 811 0.245200171953071 1199 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1909 st060837 51.5 µM 0.689424618228348 0.238030547925726 no 812 0.245278047826447 1163 678937 SGTC_2627 acetyl isogambogic acid 100 µM 0.689197645159993 0.238103420229904 no 813 0.245349449257818 1179 6857789 A caspase activator and apoptosis inducer. SGTC_2766 oltipraz 83.91 µM 0.688626713460667 0.238286778438207 no 814 0.245529102947384 1187 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1236 0330-0013 258 µM 0.687808741416804 0.238549609893362 no 815 0.245786615326131 1194 4617066 SGTC_230 MPP+ 141.667 µM 0.686167007543793 0.239077611723487 no 816 0.246303900046668 1185 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2260 7964312 200 µM 0.684599236850141 0.239582421789542 no 817 0.246798424375804 1240 231951 SGTC_270 tamoxifen 5.46 µM 0.683902713471572 0.239806883480931 no 818 0.24701830023616 1301 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1602 st001878 87.6 µM 0.682934713032164 0.240119021820219 no 819 0.247324048904261 1236 595405 YLR310C CDC25 SGTC_1201 1889-3372 45.9 µM 0.682619185074318 0.240220813800493 no 820 0.24742375397902 1150 5392199 SGTC_705 1124-0212 310 µM 0.681462023673497 0.24059432500984 no 821 0.247789594301499 1220 9554485 SGTC_3199 9111318 49.47 µM 0.680766784923498 0.240818887724269 no 822 0.248009535086686 1175 8548020 SGTC_1963 st076565 50.3 µM 0.680384415763163 0.240942441883026 no 823 0.248130543057739 1239 4914280 SGTC_624 k048-0052 28 µM 0.679802528058329 0.241130532198009 no 824 0.248314752867059 1186 6835531 SGTC_1955 wogonin 32.4 µM 0.679097108865274 0.241358660028934 no 825 0.248538167113123 1275 5281703 A flavanone. SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.67839188683826 0.241586841257622 no 826 0.248761625921411 1206 803109 SGTC_3349 9149703 23.001 µM 0.677878511303609 0.241753022388455 no 827 0.24892436292136 1215 4910494 SGTC_3203 9113543 49.47 µM 0.676162157026609 0.242309061343101 no 828 0.249468848168534 1250 17018012 SGTC_2869 9037858 32.47 µM 0.674551983314471 0.242831330930354 no 829 0.249980224187997 1202 27187042 SGTC_1656 st012921 11 µM 0.674413547844163 0.24287626173424 no 830 0.250024215944516 1174 6732821 SGTC_1645 Cervolide 78 µM 0.673534426890801 0.243161695381856 no 831 0.250303677147128 1178 23173 A fragrance. SGTC_2923 7992654 58.14 µM 0.670029711586915 0.244301409565905 no 832 0.251419425003378 1253 2985126 SGTC_1369 1866-0067 208 µM 0.669827777309639 0.244367165101843 no 833 0.251483792029741 1257 3531355 SGTC_3295 9122362 53.5725 µM 0.668871856274305 0.244678569544921 no 834 0.251788612252052 1237 4730473 SGTC_2318 6029776 164 µM 0.668865811378716 0.244680539432571 no 835 0.251790540444329 1253 818325 SGTC_340 k038-0059 454 µM 0.668289642284054 0.244868338424216 no 836 0.251974361829886 1233 23733424 SGTC_1623 st003709 20.3 µM 0.666545157943297 0.245437415721443 no 837 0.252531354838353 1235 16192618 SGTC_3173 9105693 49.47 µM 0.666513539072014 0.245447736830782 no 838 0.252541456348331 1290 17096658 SGTC_1739 st037196 92.5 µM 0.665557174705735 0.245760025805253 no 839 0.252847093577782 1251 612214 SGTC_2592 piperlongumine 83.33 µM 0.665201049450047 0.24587636859351 no 840 0.252960954678782 1214 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2645 abamectin 100 µM 0.665110830331771 0.24590584702731 no 841 0.252989804004287 1225 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_75 0159-0059 199.013 µM 0.66464624353686 0.246057677374639 no 842 0.253138392115647 1340 5377270 SGTC_1506 4226-2149 212 µM 0.663377114372715 0.246472694222823 no 843 0.253544529676119 1269 991114 SGTC_642 0335-0876 158 µM 0.66324545498085 0.246515769511918 no 844 0.253586681955433 1259 6812350 SGTC_3018 9082602 49.47 µM 0.662518517562761 0.246753675801384 no 845 0.253819485649103 1244 17332089 SGTC_1755 st041960 45.185 µM 0.662168368104024 0.246868313780034 no 846 0.253931661993218 1253 2257073 SGTC_1769 st044406 64.4 µM 0.6603950870962 0.247449318640919 no 847 0.254500162052691 1253 670903 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.660281315321782 0.247486620208097 no 848 0.254536659147366 1316 94937 An inhibitor of serotonin biosynthesis. SGTC_3223 9129970 49.47 µM 0.658927853076723 0.247930600927916 no 849 0.25497104948888 1305 17248386 SGTC_2493 resveratrol 26.09 µM 0.657822843313861 0.248293395901904 no 850 0.255325987031423 1192 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_167 3672-0051 66.205 µM 0.657442067165543 0.248418477234444 no 851 0.255448355032343 1222 3237971 SGTC_1729 st035615 45.989 µM 0.656656070859611 0.248676775694879 no 852 0.255701043355552 1241 17385451 SGTC_2845 9003024 42.97 µM 0.656616970955399 0.248689628655698 no 853 0.255713616909606 1312 2990173 SGTC_2532 xanthone 78.9 µM 0.653486481870762 0.249719833349738 no 854 0.256721350763505 1207 7020 An insecticide. SGTC_2321 7390090 138.78 µM 0.653360663847111 0.249761285804545 no 855 0.256761895942775 1201 649046 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.650466208640275 0.250715911333069 no 856 0.257695561118782 1275 442882 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.649694738008583 0.250970677214148 no 857 0.257944711771911 1294 279621 SGTC_302 1094-0063 18.9 µM 0.649443097090002 0.251053807238612 no 858 0.258026007601691 1219 5440289 SGTC_1145 3546-0597 10.2 µM 0.649033346335246 0.251189200296099 no 859 0.258158411275126 1243 875334 SGTC_786 4544-0069 423 µM 0.648744421900927 0.251284692183042 no 860 0.258251793242127 1307 748821 YLR208W SEC13 SGTC_1775 st081588 35.1725 µM 0.647126412614658 0.251819811996646 no 861 0.258775066122605 1291 1426443 YGL099W LSG1 SGTC_2272 7805186 180 µM 0.646116076296212 0.252154262649259 no 862 0.259102092380852 1257 2956062 YPR165W RHO1 SGTC_1433 4060-0023 7.6 µM 0.645764692980336 0.252270635613942 no 863 0.259215878401093 1297 3840627 SGTC_2447 5741742 33.78 µM 0.645147989609709 0.252474947106572 no 864 0.259415643597894 1322 1776504 SGTC_719 2810-4230 27.3 µM 0.645052334724199 0.252506645017544 no 865 0.259446635660555 1252 721079 SGTC_2122 5258151 111.688 µM 0.644324370551811 0.252747944911229 no 866 0.259682557780684 1253 2173356 SGTC_2328 6201408 200 µM 0.640767071128939 0.253928834952601 no 867 0.260837015034532 1253 2890418 SGTC_2969 9091408 28.7 µM 0.636516600640522 0.255343619397337 no 868 0.262219882205233 1252 4286311 SGTC_652 0437-0092 114 µM 0.634356940004309 0.256064045573581 no 869 0.262923952204406 1270 3091274 SGTC_1708 st033234 31.827 µM 0.634335096631793 0.256071337564421 no 870 0.262931078286514 1362 674664 SGTC_2244 6635614 200 µM 0.634325031716284 0.256074697579816 no 871 0.262934361851822 1253 836499 SGTC_1341 1486-1360 280 µM 0.634246318600843 0.256100975521453 no 872 0.262960041842105 1279 3976547 SGTC_1807 st050092 58.9 µM 0.633860202699823 0.256229898563568 no 873 0.263086029919738 1260 5008496 SGTC_1928 4'-methoxychalcone 40.3 µM 0.633590629456734 0.256319928385458 no 874 0.26317400887498 1345 641818 SGTC_2610 ononetin 44.17 µM 0.632530576444936 0.256674115874501 no 875 0.263520117535057 1288 259632 SGTC_1366 1683-0113 21.9 µM 0.631914770273828 0.256879987487458 no 876 0.2637212856517 1296 708623 SGTC_2873 9040596 71.43 µM 0.63055275032331 0.257335632602726 no 877 0.264166500746634 1285 6463863 SGTC_26 0302-0163 425.158 µM 0.630256298028008 0.257434862287079 no 878 0.264263455348339 1299 3100915 SGTC_2339 9000433 200 µM 0.629568825637988 0.257665052244569 no 879 0.264488362623283 1259 2988954 SGTC_2437 5741531 144.16 µM 0.625077063913218 0.259171678156122 no 880 0.265960240289345 1401 2262990 SGTC_425 3825-7017 13.1 µM 0.624098914973002 0.259500371485268 no 881 0.266281313225659 1384 3397440 SGTC_1878 temozolomide 1 mM 0.623775546623386 0.25960908224643 no 882 0.26638750054572 1282 5394 DNA alkylating agent. SGTC_31 0508-1974 57.237 µM 0.623365858015713 0.259746846118904 no 883 0.266522064371794 1261 6810525 SGTC_2047 4141938 200 µM 0.623225345078202 0.259794104366026 no 884 0.266568224312114 1317 3807862 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.61966549953195 0.260992853610231 no 885 0.267739017074771 1417 6728940 SGTC_2088 5278280 127.392 µM 0.618983517866324 0.261222829622897 no 886 0.267963608486959 1326 791502 SGTC_2930 9013230 14.89 µM 0.618694649786155 0.261320272319254 no 887 0.268058767629312 1306 2995857 SGTC_1818 st052136 56.3 µM 0.618425531033553 0.261411069852787 no 888 0.268147436237247 1231 674169 SGTC_1974 st069448 26.9 µM 0.617166653529708 0.261836015511325 no 889 0.268562404131116 1299 6323587 YNR016C ACC1 SGTC_110 0850-0284 111.64 µM 0.615666657293201 0.262342815208629 no 890 0.269057273853203 1181 3906265 SGTC_459 nigericin 15.3 µM 0.615641386535344 0.262351357672773 no 891 0.269065614947687 1361 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2934 9036370 36.88 µM 0.613204482052084 0.263175791479965 no 892 0.269870570772688 1343 6462800 SGTC_1331 1472-0049 76.2 µM 0.610574608850607 0.264066991434333 no 893 0.27074061825736 1290 24051409 SGTC_406 estrone 100 µM 0.609806454908471 0.264327589945791 no 894 0.270995012542545 1397 5870 A steroid. SGTC_486 niguldipine 82 µM 0.609558385994173 0.264411776023949 no 895 0.271077192523037 1328 1236 A calcium channel blocker. SGTC_962 1254-0300 21.5 µM 0.609527432224199 0.264422281629047 no 896 0.271087447724001 1334 7340576 SGTC_2867 9039098 71.43 µM 0.609430492953011 0.264455183865078 no 897 0.271119565635843 1294 6463460 SGTC_3122 9126309 49.47 µM 0.609008358567684 0.264598485123814 no 898 0.271259449287816 1349 17591206 SGTC_3123 9126162 49.47 µM 0.607906805848386 0.26497261333401 no 899 0.271624642713554 1376 25239884 SGTC_1514 1189-1591 158 µM 0.605790689440075 0.26569207844186 no 900 0.272326876552529 1412 767698 YMR146C TIF34 SGTC_303 1348-1668 34.2 µM 0.605171878387544 0.265902656987477 no 901 0.272532399489652 1346 5380509 SGTC_2970 9090938 41.86 µM 0.603666115505763 0.266415414161808 no 902 0.273032823215807 1347 17217104 SGTC_703 3875-0075 71.8 µM 0.602127784105054 0.266939777988312 no 903 0.273544540677426 1391 2850814 SGTC_2091 4-phenylthiadiazole 200 µM 0.601024216940863 0.267316266633776 no 904 0.273911928372661 1342 270010 SGTC_799 1310-0557 151 µM 0.600543026346531 0.267480511565849 no 905 0.274072197495223 1362 5354492 SGTC_322 k048-0136 19.3 µM 0.598310751751036 0.268243119584374 no 906 0.27481630191839 1340 6823282 SGTC_2647 atorvastatin 60.16 µM 0.597515093285115 0.268515203176789 no 907 0.275081766531873 1368 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2026 5148700 152 µM 0.595665502074895 0.269148225540021 no 908 0.275699354371968 1337 79838 SGTC_3030 9087619 49.47 µM 0.594001556646455 0.269718349740631 no 909 0.276255535913142 1302 25236973 SGTC_2054 5233173 129 µM 0.591374419569027 0.270619725775024 no 910 0.27713478806889 1388 6889 SGTC_2480 5767542 37.17 µM 0.590712394793392 0.270847104916594 no 911 0.277356570814869 1367 2867358 SGTC_1383 3049-0032 20.7 µM 0.590637958302848 0.270872676848337 no 912 0.277381512965543 1408 712864 SGTC_638 3970-0837 4.09 µM 0.590621456778565 0.270878345949535 no 913 0.277387042438465 1340 4118451 YLR208W SEC13 SGTC_3006 9075424 71.4286 µM 0.590319910799952 0.270981952543071 no 914 0.27748809655233 1309 7465181 SGTC_1621 st003705 32.4 µM 0.589844197809246 0.271145440448302 no 915 0.277647554104613 1386 24207032 SGTC_350 k064-0020 19.8 µM 0.589279359621412 0.271339621786527 no 916 0.277836944261528 1407 2790705 SGTC_2780 5215298 71.43 µM 0.587905218650542 0.271812316240693 no 917 0.278297956707483 1360 2834131 SGTC_1948 st076329 66.6 µM 0.58607081067599 0.272443977146989 no 918 0.278913965347217 1278 24208413 SGTC_856 0433-0016 11.3 µM 0.584945429324223 0.272831851966575 no 919 0.279292205299783 1353 3911780 SGTC_3310 9130229 44.1445 µM 0.583809650019265 0.273223588073415 no 920 0.279674192531631 1418 7761258 SGTC_3353 9151644 39.2805 µM 0.581658275138094 0.273966371273151 no 921 0.280398440839472 1352 4909158 SGTC_45 0kpi-0036 14.9 µM 0.581373169680578 0.274064881564862 no 922 0.280494488096884 1382 2795021 SGTC_1970 st070122 35.8 µM 0.580812004597504 0.274258827723954 no 923 0.280683581726777 1417 102928 SGTC_1117 retinoic acid 1.10837 µM 0.580794982833486 0.274264711732201 no 924 0.280689318448273 1437 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1929 genistein trimethyl ether 50.5 µM 0.580499137936464 0.274366988045943 no 925 0.280789033963148 1389 136420 SGTC_120 rhodamine 6G 52.259 µM 0.57990211444074 0.274573441899943 no 926 0.28099031488281 1360 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_841 0251-0215 91.2 µM 0.579624744062427 0.274669384096921 no 927 0.281083851441939 1390 3888614 SGTC_1799 st045822 46.1415 µM 0.576993133938163 0.275580477677055 no 928 0.281972046885321 1359 3674992 SGTC_1917 st066507 28.5 µM 0.573983498311326 0.276624266372801 no 929 0.282989483997899 1387 3156428 SGTC_3350 9150499 3.57 µM 0.573871531339492 0.27666313562189 no 930 0.283027369518761 1330 4910996 YPR165W RHO1 SGTC_1024 4507-0395 26 µM 0.572638512164835 0.277091354229962 no 931 0.283444738976176 1409 4201836 SGTC_1844 rapamycin 4 nM 0.572480761969311 0.277146163122227 no 932 0.283498157733123 1361 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.570237372385656 0.27792618233953 no 933 0.284258355745406 1377 2724 A muscle relaxant with antifungal properties. SGTC_2331 7980721 200 µM 0.567000479485198 0.279053524288455 no 934 0.285356927925187 1412 2981221 SGTC_2591 skatole 100 µM 0.565492504289425 0.279579478670476 no 935 0.285869410626878 1397 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_771 0250-0039 27.3 µM 0.565199752958122 0.279681640776615 no 936 0.285968952350767 1401 3005115 SGTC_2440 5628896 157.78 µM 0.564686119063232 0.279860928545651 no 937 0.286143638676942 1420 5522048 SGTC_3037 9091026 49.47 µM 0.564459748402336 0.279939962618953 no 938 0.286220643181034 1397 25236398 YIL048W NEO1 SGTC_2356 9061756 188.97 µM 0.564429414201774 0.279950554192763 no 939 0.286230962713254 1390 20104043 SGTC_1209 2323-2347 50.3 µM 0.564335444056158 0.279983366303336 no 940 0.28626293197387 1387 5412760 SGTC_567 1080-0542 68.4 µM 0.56402175081718 0.280092913922935 no 941 0.286369664748953 1357 5950415 SGTC_3307 9126885 69.2785 µM 0.563922053193879 0.280127734570724 no 942 0.286403590391697 1357 24824909 SGTC_3000 9075062 71.4286 µM 0.563821076119273 0.280163004221134 no 943 0.286437953357287 1375 17057871 SGTC_84 0443-0269 128.823 µM 0.56290015412396 0.280484766559503 no 944 0.286751437628851 1344 6150058 SGTC_1452 4194-0072 190 µM 0.562882561927156 0.280490914864618 no 945 0.286757427641756 1489 1343545 SGTC_1673 st016611 27.3 µM 0.562230592264553 0.28071881804229 no 946 0.286979460312058 1478 5226799 SGTC_410 α-linolenic acid 100 µM 0.562208370488005 0.280726587487163 no 947 0.286987029523005 1416 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3154 9100113 49.47 µM 0.562024840278809 0.280790759503251 no 948 0.28704954744131 1360 25237525 SGTC_886 0866-0150 153 µM 0.562009818515896 0.280796012232219 no 949 0.287054664755545 1480 271463 SGTC_676 falcarinol 140 µM 0.560674492322125 0.281263131625147 no 950 0.287509729538564 1509 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2854 9024559 71.43 µM 0.559777965570343 0.281576962008166 no 951 0.287815447463493 1356 3163529 SGTC_648 0375-0473 33.3 µM 0.557218344516037 0.282473889034545 no 952 0.288689128782167 1413 1713139 SGTC_875 0709-0210 25.7 µM 0.557001090062613 0.282550081245456 no 953 0.288763342210594 1428 6251364 SGTC_248 streptozotocin 5.23457 mM 0.55675875364102 0.282635081482135 no 954 0.288846134155595 1453 5300 DNA alkylating agent. SGTC_1138 3761-0006 1.03 µM 0.556022825694157 0.282893285752126 no 955 0.289097625434207 1409 12061087 SGTC_1338 1486-1223 76 µM 0.555484209835001 0.283082333780239 no 956 0.289281753789455 1473 3444526 SGTC_1457 k015-0032 57.3 µM 0.554738385475368 0.283344209691168 no 957 0.289536808303785 1394 4302660 SGTC_817 1391-0715 46 µM 0.553814576306435 0.283668741084031 no 958 0.289852875790618 1373 1353946 SGTC_2402 5553605 200 µM 0.551701238717635 0.284411819038566 no 959 0.290576530572302 1475 6758546 SGTC_438 sphingosine 6.67 µM 0.550268568759985 0.284916093471798 no 960 0.291067589585703 1268 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_218 alverine citrate 93.75 µM 0.550204479893218 0.284938661579215 no 961 0.291089565609107 1438 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2719 novobiocin 32.65 µM 0.549490484448927 0.285190143950096 no 962 0.291334446493686 1477 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_485 niflumic acid 177 µM 0.548005524352903 0.285713512791527 no 963 0.291844054795988 1451 4488 A COX2 inhibitor. SGTC_421 streptovitacin 30 mM 0.546656019075026 0.286189537007003 no 964 0.292307537593618 1440 91467 include heat shock SGTC_2434 5670830 169.91 µM 0.544638730260058 0.286901816647603 no 965 0.293001005899514 1412 1549830 SGTC_1445 4239-0156 97.7 µM 0.542683529365784 0.287592974364764 no 966 0.293673858218649 1555 4008346 SGTC_1091 telmisartan 47.6 µM 0.540809635222692 0.288256128129624 no 967 0.294319400466382 1485 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1397 3532-0190 20.1 µM 0.540650650245053 0.288312424613253 no 968 0.294374199723626 1425 5322280 SGTC_90 0870-0863 4.608 µM 0.539869003398248 0.288589280662125 no 969 0.294643687799639 1399 1738164 SGTC_778 3456-2434 196 µM 0.539096689412082 0.288862953999836 no 970 0.294910069904792 1570 5539063 SGTC_2678 equilin 100 µM 0.538665098070633 0.289015943742888 no 971 0.295058980236494 1509 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1443 4112-3303 14 µM 0.538367934427905 0.289121303943028 no 972 0.295161529614347 1406 704433 SGTC_993 3909-8757 62.7 µM 0.535370090040818 0.290185206865744 no 973 0.296196984180731 1429 4288324 YLR208W SEC13 SGTC_2354 9060492 162 µM 0.534691528775524 0.29042627534332 no 974 0.296431590117072 1520 6471895 SGTC_181 1447-1644 8.07 µM 0.53386039210292 0.290721676067438 no 975 0.296719063505581 1421 534600 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.533663209306665 0.290791778949717 no 976 0.296787283782348 1461 5357218 A potent inhibitor of glutathione S-transferases. SGTC_859 0439-0102 54.6 µM 0.533384134861879 0.290891009646124 no 977 0.296883848775283 1462 610143 SGTC_2391 6285546 200 µM 0.532225059275718 0.291303312238659 no 978 0.297285064446144 1397 846083 SGTC_2803 7707263 71.43 µM 0.530463878849726 0.291930315139921 no 979 0.297895173343471 1432 2199229 SGTC_2397 5161689 200 µM 0.529608193782613 0.292235176728241 no 980 0.298191806063653 1520 2259942 SGTC_3017 9080681 49.47 µM 0.529507186385515 0.292271173191936 no 981 0.298226830273969 1413 16451914 SGTC_2585 alliin 100 µM 0.527690362603162 0.292918994802043 no 982 0.298857131673186 1561 87310 A garlic compound which reacts with lipids. SGTC_576 1073-0113 22.7 µM 0.52550225332134 0.293700088406849 no 983 0.299617043641288 1542 5439563 SGTC_760 0568-0725 82.9 µM 0.524299030113829 0.294130015708186 no 984 0.300035285687317 1506 3916171 SGTC_2884 9058502 51.95 µM 0.524113409648367 0.294196366200089 no 985 0.30009983112694 1423 6471554 SGTC_3263 9137018 49.47 µM 0.523181739608418 0.294529498358812 no 986 0.300423893746365 1379 43844957 SGTC_476 mead acid 10 µM 0.522202095077997 0.294879972126345 no 987 0.300764813730565 1472 5312531 An omega 9 fatty acid. SGTC_965 1291-5240 308 µM 0.521627201356308 0.295085733294646 no 988 0.300964960150553 1540 2834598 SGTC_232 clozapine 119 µM 0.521530972068957 0.295120181338496 no 989 0.300998467769637 1453 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2904 7225135 42.03 µM 0.520813153485639 0.295377203575589 no 990 0.301248469580002 1503 4446116 SGTC_3222 9128301 49.47 µM 0.52063974542168 0.295439309535886 no 991 0.30130887815207 1442 4911358 SGTC_1139 k015-0024 46.9 µM 0.520542779180293 0.295474040536426 no 992 0.301342659767297 1451 2766652 SGTC_72 0744-0168 198.391 µM 0.520426318540095 0.29551575644864 no 993 0.301383235198762 1494 677577 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.519757021082387 0.295755549626966 no 994 0.301616469229291 1552 5282309 SGTC_1659 st012954 42.1 µM 0.519670479963853 0.295786561753931 no 995 0.301646632649386 1470 24207262 SGTC_479 n-linoleoylglycine 10 µM 0.515476368610651 0.297291314378393 no 996 0.303110089419708 1461 6433346 An anti-infammatory. SGTC_751 0833-0568 350 µM 0.513229823357437 0.298098760141408 no 997 0.303895283270238 1475 6954252 SGTC_3060 1327-0027 12.5 µM 0.509141424357964 0.299570756537126 no 998 0.305326548790423 1458 16000455 YPR107C YTH1 SGTC_2657 nystatin 74.44 µM 0.507952434059071 0.299999460752208 no 999 0.30574335074134 1502 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_670 4204-0025 119 µM 0.5074512615559 0.300180247425564 no 1000 0.305919112816611 1531 719039 SGTC_740 k014-0057 261 µM 0.504422112373487 0.301273991719157 no 1001 0.306982391252319 1571 4012779 SGTC_2086 5274770 176.623 µM 0.50321676924254 0.301709707313558 no 1002 0.307405938032352 1474 689278 SGTC_1663 st014140 55.4 µM 0.50230004267591 0.302041281406737 no 1003 0.307728239608306 1547 4207120 SGTC_857 0438-0306 1.35 µM 0.5019991625343 0.302150143473364 no 1004 0.307834055036941 1487 4686136 SGTC_348 k064-0012 10.7 µM 0.501644131619254 0.302278620591505 no 1005 0.307958935108652 1451 5066323 SGTC_1269 0831-0796 3.05 µM 0.501352422288832 0.30238420149672 no 1006 0.308061558825662 1548 927758 SGTC_1296 1068-0102 11.9 µM 0.501319911146705 0.302395969562634 no 1007 0.308072997216969 1522 767053 SGTC_1442 4112-3290 3 µM 0.500612965818655 0.302651913508215 no 1008 0.308321767795 1465 704353 SGTC_1790 st045711 43.5 µM 0.500453470055699 0.302709671100358 no 1009 0.308377905745999 1604 585119 SGTC_766 1391-0721 126 µM 0.499302224520496 0.303126713613252 no 1010 0.308783244117557 1584 1020919 YIL115C NUP159 SGTC_2588 indole-3-carbinol 100 µM 0.49892484872453 0.303263475151593 no 1011 0.308916163898887 1588 3712 Induces cell cycle arrest. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.497830768704032 0.303660127160475 no 1012 0.30930166356789 1573 5024745 SGTC_1855 st056195 39.6 µM 0.496339357417055 0.304201201850091 no 1013 0.309827501336348 1552 4028379 SGTC_2913 7966556 36.57 µM 0.495858920588985 0.304375592744142 no 1014 0.309996975422354 1549 2976516 SGTC_2561 acetosyringone 100 µM 0.495797809991979 0.30439777810496 no 1015 0.310018535080091 1441 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_578 3460-0051 92 µM 0.495432888046362 0.304530272973147 no 1016 0.310147292176865 1521 2876744 SGTC_3237 9133362 49.47 µM 0.494538599260164 0.304855077350354 no 1017 0.310462926629495 1540 43845137 SGTC_2191 5911152 200 µM 0.49421187023182 0.304973783239711 no 1018 0.310578278730074 1494 2875902 SGTC_1386 3228-0095 33.8 µM 0.493740585098334 0.305145044833141 no 1019 0.310744699359039 1567 870181 SGTC_552 k242-0005 476 µM 0.492917020290114 0.305444424735267 no 1020 0.311035610259603 1484 4088318 SGTC_2364 9055074 200 µM 0.49146033720075 0.305974272588442 no 1021 0.31155044905117 1456 6470630 SGTC_378 3970-0959 8.33 µM 0.49124082456426 0.306054152452917 no 1022 0.311628063885184 1499 6615653 SGTC_1416 3966-0321 25.3 µM 0.490010389664032 0.30650207398636 no 1023 0.312063273435088 1503 582530 YLR208W SEC13 SGTC_1467 k284-1082 293 µM 0.488223223499145 0.307153180313397 no 1024 0.312695868327283 1570 3334705 SGTC_2769 toremifene 3.73 µM 0.486165244858931 0.307903703738112 no 1025 0.313425005411657 1526 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1450 4112-4260 37.6 µM 0.485753924367113 0.308053804586769 no 1026 0.313570822905639 1569 1633175 SGTC_757 1066-0008 322 µM 0.484870536206545 0.308376282929572 no 1027 0.3138840918781 1562 6842497 SGTC_1926 methyl fluorone black 53.6 µM 0.483058165449367 0.309038346573871 no 1028 0.314527218541717 1407 72721 Reacts with homocysteine. SGTC_1744 st037937 38.9 µM 0.482284306855804 0.309321228340315 no 1029 0.314801996912359 1568 1016152 SGTC_2363 9053361 176 µM 0.482256866249154 0.309331261250984 no 1030 0.31481174228838 1619 6469797 YMR079W SEC14 SGTC_2649 anisomycin 9.56 µM 0.481785992444783 0.309503445580151 no 1031 0.314978990542026 1481 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1280 0880-0253 10.1 µM 0.48103846282573 0.309776880481812 no 1032 0.315244581271016 1493 6836607 SGTC_1475 4092-1048 11.7 µM 0.481021545326842 0.309783069863035 no 1033 0.315250593016027 1487 2881759 SGTC_582 0987-0078 156 µM 0.480767668012688 0.309875959069029 no 1034 0.315340815872129 1500 1625765 SGTC_1037 k284-1091 78.7 µM 0.48071723992266 0.30989441125796 no 1035 0.315358738305244 1487 3334711 SGTC_3275 9138069 49.47 µM 0.479876782769399 0.310202014186746 no 1036 0.315657505545177 1544 17617007 SGTC_1020 4335-0961 93.3 µM 0.478164098656798 0.310829258649085 no 1037 0.316266706480697 1436 669075 SGTC_2782 7736369 71.43 µM 0.477890967986295 0.310929339502348 no 1038 0.316363905112017 1518 2950836 YOL077C BRX1 SGTC_2805 7950783 58.44 µM 0.47740049239623 0.311109095236086 no 1039 0.316538481823017 1562 1178958 YDL195W SEC31 SGTC_2582 agaric acid 100 µM 0.477008381806831 0.3112528333316 no 1040 0.316678076539249 1415 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2743 auranofin 4.32 µM 0.475401974108818 0.311842003215738 no 1041 0.317250243832578 1538 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1027 k015-0025 8.67 µM 0.472211944236242 0.313013413562625 no 1042 0.318387757516836 1478 3598955 SGTC_3227 9130768 49.47 µM 0.469865905421907 0.313876109111044 no 1043 0.319225412271212 1553 17720899 SGTC_1311 1190-0148 100 µM 0.469816940183478 0.313894125686168 no 1044 0.319242905197935 1626 1961333 SGTC_379 3970-0972 5.9 µM 0.469725061973422 0.313927933124993 no 1045 0.319275729953256 1549 2898042 YBL034C STU1 SGTC_1148 3909-7663 27.7 µM 0.467628619009174 0.31469976271427 no 1046 0.320025097585977 1589 4084526 SGTC_1259 0671-0132 43 µM 0.467236811384571 0.314844101167469 no 1047 0.320165229714956 1511 X1259 SGTC_2251 lansoprazole 556 µM 0.465330686360745 0.315546703962296 no 1048 0.320847331408861 1461 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1381 2324-0066 62.1 µM 0.465114032298315 0.315626605512018 no 1049 0.320924898824898 1556 10885928 SGTC_3035 9091303 49.47 µM 0.462245924781801 0.316685168495455 no 1050 0.321952486556035 1539 25237002 SGTC_309 k408-0051 1.48 µM 0.461653407146336 0.316904042892384 no 1051 0.3221649443486 1537 3640463 SGTC_3052 9092717 49.47 µM 0.460430264239156 0.317356071198388 no 1052 0.322603707877382 1522 25237534 SGTC_212 3807-4682 38.772 µM 0.459888829800298 0.317556252376759 no 1053 0.322798009175764 1640 3125501 YBL034C STU1 SGTC_2981 9013952 38.96 µM 0.4588354716669 0.317945856758367 no 1054 0.323176160029345 1433 2996344 SGTC_987 1497-1013 404 µM 0.457607259305897 0.318400388837635 no 1055 0.323617313593739 1565 1676435 SGTC_3265 9137266 49.47 µM 0.454804779799909 0.319438542794883 no 1056 0.32462484562253 1667 17224265 SGTC_2746 daunorubicin 9.88 µM 0.453718549162946 0.31984130890339 no 1057 0.325015707189532 1572 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1794 st048918 76.9 µM 0.452312348660236 0.320363032998604 no 1058 0.325521990578669 1597 672303 SGTC_1140 3229-1848 2.98 µM 0.452281677442006 0.32037441650005 no 1059 0.325533036926615 1622 2849525 SGTC_3067 9117431 49.47 µM 0.452122786318088 0.320433391018371 no 1060 0.32559026458096 1554 17150885 SGTC_1839 st053978 48 µM 0.451942658799475 0.320500253186486 no 1061 0.325655145898141 1570 3788398 SGTC_2877 9040724 71.43 µM 0.450568630617022 0.3210104751357 no 1062 0.326150239856552 1654 6463895 SGTC_644 1498-1197 63.3 µM 0.449580363868541 0.321377660294131 no 1063 0.326506524708724 1597 6741615 SGTC_2038 4100038 30.985 µM 0.449552678690999 0.321387949088151 no 1064 0.326516507907938 1586 3596803 SGTC_1754 st042065 16.137 µM 0.449134032713479 0.321543549485626 no 1065 0.326667485642951 1500 1126236 YIL048W NEO1 SGTC_3333 9141820 12.094 µM 0.448476820021632 0.321787882414917 no 1066 0.326904555770698 1547 1939433 SGTC_2011 4012611 177 µM 0.44845537376843 0.321795856819319 no 1067 0.32691229305299 1513 2049887 SGTC_3273 9137859 49.47 µM 0.448340359793475 0.321838624102412 no 1068 0.326953788544592 1602 2377234 SGTC_3024 9090631 49.47 µM 0.447516720796767 0.322144958456538 no 1069 0.327251008893345 1616 25236383 SGTC_1258 0671-0043 57.1 µM 0.447330641588141 0.322214183257379 no 1070 0.327318173063713 1510 4298767 SGTC_1773 st048542 73.5835 µM 0.446758830805775 0.322426945702944 no 1071 0.327524599703581 1471 3237138 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.446199561755066 0.322635097831722 no 1072 0.327726549732365 1649 1377 SGTC_1185 1319-0113 81.3 µM 0.445085959948488 0.323049730386827 no 1073 0.328128817357829 1605 4672763 SGTC_1040 k898-0338 155 µM 0.445030827128414 0.323070263966064 no 1074 0.328148738232579 1735 20969351 SGTC_2635 hydroquinidine 100 µM 0.444958748701886 0.323097109553074 no 1075 0.328174782718412 1571 442912 An experimental heart treatment. SGTC_1596 piperlongumine 63 µM 0.443118256197352 0.323782912238841 no 1076 0.328840100462998 1664 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_255 tunicamycin 200.472 nM 0.44305284110425 0.323807298184632 no 1077 0.328863757297966 1643 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3038 9091290 49.47 µM 0.442781079308324 0.323908615752227 no 1078 0.328962045075384 1608 25236843 SGTC_2991 9074669 71.4286 µM 0.44261815397565 0.323969363432543 no 1079 0.329020975765215 1655 17333109 SGTC_1520 flindersine 88 µM 0.441779153569653 0.32428226393475 no 1080 0.329324512551151 1728 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_69 0096-0274 206.684 µM 0.440841974353157 0.324631926446226 no 1081 0.32966370188575 1647 6741392 SGTC_3256 9138902 49.47 µM 0.440702145412971 0.324684110028126 no 1082 0.329714321608675 1619 17228773 SGTC_1681 tripelennamine 100 µM 0.440524977629155 0.324750233254434 no 1083 0.329778462912713 1517 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2605 digitonin 300 nM 0.440075240670374 0.324918110573547 no 1084 0.329941306840318 1637 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_996 3970-0799 1.8 µM 0.439775427781671 0.325030044156606 no 1085 0.330049883111876 1650 6615648 YGL040C HEM2 SGTC_2764 methyldopa 94.69 µM 0.439657914906722 0.325073921286596 no 1086 0.330092443926796 1659 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1670 st016595 4.04 µM 0.439535652476589 0.325119574387543 no 1087 0.330136727269775 1560 597879 SGTC_2797 7859098 81.82 µM 0.439140389959222 0.325267184373617 no 1088 0.330279907280973 1549 972681 SGTC_1552 6-methylflavone 10.6 µM 0.438445026199344 0.325526933101868 no 1089 0.330531856368718 1623 689013 SGTC_2245 6637752 200 µM 0.43834622955917 0.325563844840291 no 1090 0.330567659297551 1705 681890 SGTC_1114 scopoletin 1.73284 µM 0.437771812952884 0.325778488399396 no 1091 0.330775852921406 1667 5280460 A coumarin with genotoxic properties. SGTC_106 0092-0003 11.579 µM 0.437445601291197 0.325900410374863 no 1092 0.330894109565495 1677 1072148 SGTC_1065 prochlorperazine maleate 2.48 µM 0.43704386083747 0.326050586905255 no 1093 0.331039769723938 1583 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2755 lomerizine 42.69 µM 0.436899965860445 0.326104383843329 no 1094 0.331091948349907 1533 3949 A calcium channel blocker. SGTC_3343 9148379 18.9835 µM 0.435880143987178 0.326485760682004 no 1095 0.331461846074967 1708 1955036 SGTC_3023 9089636 49.47 µM 0.435762869459861 0.326529628792529 no 1096 0.331504393053688 1648 17249241 SGTC_985 1493-0307 8.71 µM 0.435676718376423 0.326561856289782 no 1097 0.331535649890687 1675 3278274 SGTC_417 st075190 100 µM 0.435343868385865 0.326686381360254 no 1098 0.331656423617058 1661 222757 SGTC_2623 humulene 100 µM 0.435208985302297 0.326736849007091 no 1099 0.331705370566045 1529 6187145 An anti-inflammatory. SGTC_1070 indatraline 8.81 µM 0.433868437601804 0.327238598470244 no 1100 0.332191990308284 1549 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2171 5739187 198.077 µM 0.433453900887924 0.327393817406392 no 1101 0.332342524764159 1513 2262761 SGTC_1568 digitonin 820 nM 0.432441029420781 0.327773202043835 no 1102 0.332710451669296 1748 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2130 NSC 7 2.4545 µM 0.43237184197711 0.327799123625053 no 1103 0.332735589984896 1696 21448 SGTC_2344 7990960 76.95 µM 0.432257586173573 0.327841932213047 no 1104 0.332777104921708 1592 140813 SGTC_2380 9035439 200 µM 0.432088727289804 0.327905203254432 no 1105 0.332838463685249 1642 6462575 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.431336486707213 0.328187126096638 no 1106 0.33311186199899 1577 6857784 SGTC_3277 9138724 49.47 µM 0.430634905885323 0.32845015103389 no 1107 0.333366928224865 1575 15943418 SGTC_1107 amlodipine 47 µM 0.430592906018109 0.3284658996201 no 1108 0.333382200112906 1530 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2979 9012552 45.46 µM 0.4284521359926 0.329269021974427 no 1109 0.334160986957408 1621 17100905 SGTC_1927 st060202 13.8 µM 0.428369261450085 0.329300128717543 no 1110 0.334191150124022 1685 688887 SGTC_2859 9028643 45.46 µM 0.428284806768588 0.329331829777335 no 1111 0.334221889502503 1631 17151580 SGTC_2154 5570129 200 µM 0.428268060612644 0.329338115790047 no 1112 0.334227984813893 1578 673366 SGTC_3140 9094243 49.47 µM 0.426999733661642 0.329814348364066 no 1113 0.334689760842324 1576 19291112 SGTC_623 k072-0108 16.9 µM 0.426300612682026 0.330076973012112 no 1114 0.334944405752992 1601 5382803 SGTC_54 0159-0055 9 µM 0.426266278433897 0.330089872823837 no 1115 0.334956913472602 1693 3319099 SGTC_1600 coumarin 106 71.1 µM 0.424859954524755 0.330618419959739 no 1116 0.335469384326239 1637 100336 A hepatotoxic, DNA x-linker. SGTC_1132 3456-3614 2.5 µM 0.424455608039133 0.330770450521628 no 1117 0.335616786760413 1794 3125502 SGTC_2400 5203494 178.7 µM 0.424263133312282 0.330842829059318 no 1118 0.335686961322632 1542 6777674 SGTC_2299 7976368 114.88 µM 0.423798796678658 0.33101746505696 no 1119 0.335856277886624 1699 2979718 SGTC_325 2810-4341 181 µM 0.422579780490599 0.331476109298087 no 1120 0.336300940684865 1709 774970 SGTC_1921 5740136 50 µM 0.421532253824879 0.33187043411359 no 1121 0.336683231989823 1735 1774243 SGTC_700 3453-2283 142 µM 0.421204625326591 0.331993802941174 no 1122 0.336802833578118 1674 565664 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.419095149824271 0.332788563695191 no 1123 0.337573297607247 1653 6708739 YPR165W RHO1 SGTC_714 4296-0578 26.1 µM 0.418965596468848 0.332837398439517 no 1124 0.3376206378649 1682 1589775 SGTC_2381 9035592 200 µM 0.418351974918161 0.333068739735604 no 1125 0.337844896999833 1522 4749657 SGTC_1169 aniline yellow 25.8 µM 0.41750763477631 0.333387168044024 no 1126 0.338153570537648 1670 6051 A DNA damaging agent. SGTC_2518 prenyletin 46.28 µM 0.417063447154866 0.333554733965178 no 1127 0.338316000172655 1644 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1324 1418-0026 34.4 µM 0.416991087308083 0.333582034235451 no 1128 0.338342463426911 1635 1372513 SGTC_1954 st077032 68.9 µM 0.416486617065798 0.333772387671413 no 1129 0.338526979149301 1526 698907 SGTC_715 0868-0130 184 µM 0.415270480459834 0.334231452383828 no 1130 0.338971954250757 1755 2876258 SGTC_3130 9127414 49.47 µM 0.415116563462378 0.33428957034993 no 1131 0.339028287341235 1592 1494646 SGTC_1624 st003710 6.25 µM 0.414891537149744 0.334374545838198 no 1132 0.339110652673592 1699 24207033 SGTC_12 0849-0099 9.267 µM 0.413810311562544 0.334782961598795 no 1133 0.339506515820089 1665 6071388 SGTC_919 tnp00227 403.569 nM 0.412384054569745 0.335322006494508 no 1134 0.340028974322396 1625 1269246 A methoxyflavone. YNL221C POP1 SGTC_1010 4112-3296 15.2 µM 0.411629726367205 0.335607237342019 no 1135 0.340305419951926 1770 704384 SGTC_2691 st077356 60.2 µM 0.411499547310648 0.335656470974847 no 1136 0.340353136564152 1706 2839272 SGTC_2027 5150920 200 µM 0.410801047348891 0.335920691362565 no 1137 0.340609212567975 1662 786715 SGTC_2553 4-methylesculetin 85.09 µM 0.406284563586122 0.337631086861276 no 1138 0.342266763066465 1568 5319502 SGTC_1660 st012960 28.1 µM 0.40571171082023 0.337848267383931 no 1139 0.342477218295599 1620 24207266 SGTC_192 3455-0609 60.9 µM 0.405142541199333 0.338064105027066 no 1140 0.34268636885478 1647 3769639 SGTC_3110 9122132 49.47 µM 0.404781852815443 0.338200911028622 no 1141 0.342818934592324 1713 918317 SGTC_763 3453-1109 128 µM 0.404722196034624 0.338223540392069 no 1142 0.34284086243501 1722 1560353 SGTC_2950 9072895 21.46 µM 0.401976932115827 0.339265521240411 no 1143 0.343850501579234 1554 17332245 SGTC_2225 6654152 15.4 µM 0.400369233861939 0.339876304246803 no 1144 0.344442290627652 1682 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_228 caffeine 993.056 µM 0.399992185229187 0.340019610292407 no 1145 0.344581136340918 1684 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1217 1183-1422 255 µM 0.398981952439979 0.340403686507226 no 1146 0.344953251189591 1704 2849664 SGTC_1865 st057639 52.2 µM 0.396669749264741 0.341283376167773 no 1147 0.345805505253948 1624 688818 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.39654196393448 0.341332017971196 no 1148 0.345852628438086 1658 364106 SGTC_201 4262-0159 12.803 µM 0.395793275857911 0.341617060892923 no 1149 0.346128768856629 1728 1341029 SGTC_2765 myclobutanil 7.74 µM 0.395116912118489 0.341874645944027 no 1150 0.346378304082837 1617 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1655 st012546 55.1 µM 0.393068802531257 0.342655092638274 no 1151 0.347134332695711 1635 720985 YLR208W SEC13 SGTC_3072 9116419 49.47 µM 0.391152336441925 0.343385984492146 no 1152 0.347842318595924 1589 17170162 SGTC_543 3844-1095 191 µM 0.389035010259295 0.344194160754195 no 1153 0.348625123976081 1729 4230703 SGTC_2112 5488546 200 µM 0.384797680253717 0.345813670886425 no 1154 0.350193658966775 1622 600757 SGTC_2334 9017922 200 µM 0.384775479346477 0.345822163552065 no 1155 0.35020188385137 1792 3163164 SGTC_141 0443-0274 32.331 µM 0.383277234330576 0.346395476589696 no 1156 0.350757108596747 1755 1627241 SGTC_1430 4049-0248 69.1 µM 0.383223504339863 0.346416043261793 no 1157 0.350777025969943 1735 22774488 SGTC_269 exalamide 29 µM 0.382978478780694 0.346509839457998 no 1158 0.350867860618789 1693 3316 A derivative of salicylamide. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.382312125655862 0.346764968142463 no 1159 0.351114930813369 1672 688801 SGTC_618 k072-0232 33.2 µM 0.380346787029914 0.3475178478508 no 1160 0.351844004707311 1679 5872756 YGL099W LSG1 SGTC_2952 9073731 13.78 µM 0.380213445963103 0.34756894983291 no 1161 0.351893489491911 1595 16457353 SGTC_2696 st077691 74.316 µM 0.376028673080674 0.349174136673072 no 1162 0.353447789838746 1672 757133 SGTC_2269 7935389 174.42 µM 0.375442051588371 0.349399368360997 no 1163 0.353665867821498 1596 97605 SGTC_1482 3346-2049 8.48 µM 0.373401755763398 0.350183146854061 no 1164 0.354424726469285 1724 3826804 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.372910958846657 0.350371781616234 no 1165 0.354607357712481 1738 17037758 SGTC_956 1185-0240 191 µM 0.372880683260797 0.350383419059758 no 1166 0.354618624705287 1679 1416193 SGTC_2134 5324836 1.464 µM 0.37268011647679 0.350460517221069 no 1167 0.354693268405593 1697 699272 SGTC_1013 4112-3890 241 µM 0.372401203963994 0.350567741834283 no 1168 0.354797078825555 1631 705171 SGTC_889 0919-1524 82.7 µM 0.369690605574483 0.351610418289971 no 1169 0.355806516168607 1642 3905452 SGTC_3195 9113082 49.47 µM 0.368122585893399 0.352214093648447 no 1170 0.356390915241031 1804 17018038 SGTC_532 1548-0774 215 µM 0.367265874253504 0.352544078446396 no 1171 0.356710353273272 1784 5932993 SGTC_1203 3992-3522 103 µM 0.366341947222481 0.352900077407919 no 1172 0.357054966249505 1883 5322312 SGTC_1507 4075-3230 155 µM 0.36393414611413 0.35382843354078 no 1173 0.357953592822451 1753 659771 SGTC_2790 5423970 71.43 µM 0.363778110978715 0.353888624797466 no 1174 0.358011854644978 1786 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_569 4130-2812 160 µM 0.363322196808742 0.354064516663286 no 1175 0.358182106981693 1758 743552 SGTC_708 3448-5400 146 µM 0.362706936013767 0.354301933889454 no 1176 0.35841190894299 1695 3462195 SGTC_1831 st055328 12 µM 0.362053835960995 0.354554014520683 no 1177 0.358655900108325 1790 1103068 SGTC_819 1013-0258 27.7 µM 0.361291291364093 0.35484841869031 no 1178 0.358940851587878 1667 5753198 SGTC_1752 st044819 83.042 µM 0.359588556891679 0.355506125273433 no 1179 0.359577421113511 1624 441209 YML126C ERG13 SGTC_3062 9077494 49.47 µM 0.35925462137151 0.355635163403643 no 1180 0.359702309127083 1738 16459633 SGTC_3202 9113761 49.47 µM 0.358299743984371 0.356004234855619 no 1181 0.360059504838243 1841 4798415 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.356863204585879 0.356559728584166 no 1182 0.360597108414364 1625 6708514 SGTC_963 1269-2853 151 µM 0.356479981869244 0.356707968009105 no 1183 0.360740570454924 1631 3668223 SGTC_767 0929-0023 86 µM 0.356217144663838 0.356809652044281 no 1184 0.360838976689807 1679 1204563 SGTC_1305 1181-0477 144 µM 0.356007249275604 0.356890861745029 no 1185 0.360917568128585 1798 6252086 SGTC_1724 st037281 8.293 µM 0.35356002429679 0.357838184556383 no 1186 0.361834318795186 1645 574124 YDL195W SEC31 SGTC_600 1495-0418 41.6 µM 0.353527248677248 0.357850877984829 no 1187 0.361846602208578 1702 5377768 SGTC_2998 9066762 71.4286 µM 0.352029157021211 0.358431230457731 no 1188 0.362408198080731 1801 4945196 SGTC_161 4065-0411 162.148 µM 0.350226893104314 0.359129851037751 no 1189 0.363084212758418 1733 1906281 YLR208W SEC13 SGTC_1476 4112-3294 3.34 µM 0.347001501395319 0.360381301055586 no 1190 0.364295095412394 1797 704369 SGTC_1345 1488-0192 31.4 µM 0.345678699830453 0.360894980985976 no 1191 0.364792096807968 1813 658348 SGTC_258 haloperidol 50.781 µM 0.345554206664902 0.360943338016254 no 1192 0.364838882943938 1663 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1732 st034308 51.822 µM 0.344816669369755 0.361229866085876 no 1193 0.36511610022591 1665 830119 SGTC_1019 4262-0212 3.4 µM 0.343651982236795 0.361682497395882 no 1194 0.365554013355298 1842 4677213 SGTC_187 1488-2104 32.728 µM 0.343647632821996 0.361684188068255 no 1195 0.365555649029669 1784 2852859 SGTC_2311 7694451 200 µM 0.343017699500396 0.36192907959166 no 1196 0.365792572402493 1765 2163142 SGTC_2757 clomiphene 4.22 µM 0.342033626691573 0.362311758750389 no 1197 0.366162793135429 1854 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_831 k061-1017 217 µM 0.34168917761348 0.36244573817075 no 1198 0.366292408731776 1816 1240153 SGTC_1086 cerivastatin 2.18 µM 0.341650029568346 0.362460966545881 no 1199 0.366307141039643 1764 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1819 st053448 58.6 µM 0.341162512037248 0.362650626417526 no 1200 0.366490621575124 1725 2857616 SGTC_3170 9103054 49.47 µM 0.34070413218517 0.362828981547882 no 1201 0.366663163785733 1685 16432970 SGTC_597 k018-0003 82.8 µM 0.340520555744867 0.36290041930105 no 1202 0.366732272734729 1797 6786234 SGTC_1556 plumbagin 1.48 µM 0.339007556958618 0.363489375888884 no 1203 0.367302018643299 1729 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_428 3448-4153 16.5 µM 0.33819881587936 0.363804322493993 no 1204 0.367606684065839 1635 3834874 SGTC_679 0422-0091 41.4 µM 0.338193134881722 0.363806535160617 no 1205 0.367608824481546 1651 627384 YHR062C RPP1 SGTC_1419 3993-2473 62.6 µM 0.337329879499086 0.364142813419169 no 1206 0.367934118873261 1752 704026 SGTC_699 0375-0592 111 µM 0.337210995400552 0.364189132526101 no 1207 0.367978924550204 1835 762578 SGTC_1315 1237-0019 3.69 µM 0.336851640456439 0.364329154899834 no 1208 0.368114371088306 1801 825140 SGTC_114 0364-0001 490.298 µM 0.336654568754341 0.364405951424557 no 1209 0.368188657479238 1665 4003655 SGTC_3291 9121177 71.43 µM 0.333278234592508 0.365722512287355 no 1210 0.369462133713357 1690 17015612 SGTC_1112 tnp00069 1.16933 µM 0.331469933453628 0.366428289623367 no 1211 0.370144774076319 1823 145826 SGTC_1700 st030840 7.9285 µM 0.330859490359934 0.366666646850939 no 1212 0.370375311105409 1854 5499307 SGTC_3192 9110362 49.47 µM 0.330515571574519 0.366800958072758 no 1213 0.370505214347462 1763 16649480 SGTC_21 0849-0113 22.993 µM 0.328390588776484 0.367631192546785 no 1214 0.371308178940268 1704 1560156 SGTC_1758 st042942 75.2445 µM 0.328317393840136 0.367659800985134 no 1215 0.371335847024021 1815 669317 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.325791550816092 0.368647482453138 no 1216 0.372291035876638 1846 16725076 SGTC_1249 0481-0015 10.2 µM 0.32559415528216 0.368724706777702 no 1217 0.372365717424896 1698 4227577 SGTC_291 SEC14.278 35.5 µM 0.32549827877215 0.368762217131565 no 1218 0.372401992552124 1828 1068044 SGTC_1627 st003713 25.6 µM 0.32446276309002 0.369167427877805 no 1219 0.37279385468754 1711 16195070 YER133W GLC7 SGTC_2006 4011487 200 µM 0.323509518896677 0.369540573291183 no 1220 0.373154699877767 1837 45595294 SGTC_2661 dactinomycin 12.96 µM 0.321390839710549 0.370370365483479 no 1221 0.373957112035493 1763 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_318 1488-0629 67.2 µM 0.321137064657528 0.370469798411637 no 1222 0.374053261553347 1714 3662576 SGTC_3103 9120822 49.47 µM 0.318649180798313 0.371445046522138 no 1223 0.374996277509098 1862 17141819 SGTC_504 lovastatin 124 µM 0.318510667510463 0.371499367926296 no 1224 0.375048802083516 1688 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.318468920212876 0.37151574066128 no 1225 0.375064633214438 1810 5357218 A potent inhibitor of glutathione S-transferases. SGTC_867 0518-0118 155 µM 0.317801112409402 0.371777677583473 no 1226 0.375317903418377 1852 6848158 SGTC_3162 9099653 49.47 µM 0.317700081386791 0.371817310558195 no 1227 0.375356224737246 1828 25237511 SGTC_1546 5-methoxyflavanone 78.7 µM 0.315447652653158 0.372701257044196 no 1228 0.3762108953275 1894 147795 SGTC_1088 bifonazole 369 nM 0.315141323200649 0.372821525352368 no 1229 0.376327177216542 1756 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3266 9136860 49.47 µM 0.314491588142301 0.373076659496849 no 1230 0.376573852154153 1743 4871271 YPR165W RHO1 SGTC_2435 5706476 10.6 µM 0.313917948996234 0.373301959022972 no 1231 0.376791678827331 1914 5725375 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.313486888191668 0.373471288735509 no 1232 0.376955390373459 1723 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_728 3030-5151 22.5 µM 0.313309415414379 0.373541010861984 no 1233 0.377022798763709 1780 3125388 SGTC_1932 st074806 40.9 µM 0.313053271886301 0.373641646953739 no 1234 0.377120094788313 1817 17251235 SGTC_2333 9017922 200 µM 0.312366950562318 0.373911337823774 no 1235 0.377380832134095 1880 3163164 SGTC_1321 1326-2144 215 µM 0.310104706649386 0.374800726039972 no 1236 0.378240666596566 1875 3513030 SGTC_2158 5657123 3.6195 µM 0.308111145998947 0.375585035494389 no 1237 0.378998880130055 1831 2858827 SGTC_418 lividomycin a 100 µM 0.30704505883993 0.376004668337073 no 1238 0.379404537806891 1875 72394 An antibiotic. SGTC_2626 ethyl orsellinate 100 µM 0.306392450599771 0.376261620158977 no 1239 0.379652927849766 1737 75653 A natural product. SGTC_82 0054-0107 293.755 µM 0.30634581843126 0.376279982770945 no 1240 0.379670678480645 1892 3104697 SGTC_1289 0976-0073 69.1 µM 0.305178764874977 0.37673963113566 no 1241 0.380115002313277 1831 3391136 SGTC_1812 st052057 4.327 µM 0.304383992268294 0.377052755357807 no 1242 0.380417680951566 1725 3645418 SGTC_1888 azatryptophan 97.5 µM 0.303795921202159 0.377284495451508 no 1243 0.380641687190577 1752 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_592 k241-0073 46.5 µM 0.302762482102414 0.377691847952504 no 1244 0.381035438588522 1869 4230158 SGTC_1178 0988-0033 191 µM 0.302628025749589 0.377744856861511 no 1245 0.381086676970018 1807 5392207 SGTC_42 0133-0086 60.653 µM 0.300760471985965 0.378481370552281 no 1246 0.381798576171531 1697 162923 Model of phenazepam hydroxylation. SGTC_936 3005-4620 401 µM 0.296514895997577 0.380157352648164 no 1247 0.383418446410214 1910 777207 SGTC_2852 9023854 51.95 µM 0.295983567946422 0.380367258774195 no 1248 0.383621315173076 1842 19798528 SGTC_1838 st055369 84.5 µM 0.293120957162708 0.381498764810927 no 1249 0.384714849231782 1767 676036 SGTC_2217 6934799 96.0675 µM 0.29182560263821 0.382011114110977 no 1250 0.385209984400739 1875 675606 SGTC_2885 9057732 51.95 µM 0.291401397638149 0.382178944143929 no 1251 0.385372172873695 1794 6471414 SGTC_3113 9123498 49.47 µM 0.291371125822515 0.382190921558116 no 1252 0.385383747618961 1899 8897275 SGTC_1679 SEC14.276 6.7 µM 0.291316552537989 0.382212514430571 no 1253 0.385404614542906 1945 1005053 YMR079W SEC14 SGTC_2960 9079389 5.97 µM 0.289024620123669 0.383119687464609 no 1254 0.386281268528697 1918 16457355 SGTC_2539 epi(13)torulosol 80 µM 0.287564409908252 0.383697990165646 no 1255 0.386840095676844 1744 6708597 SGTC_1625 st003711 30.1 µM 0.285130732459372 0.384662400835152 no 1256 0.387771992888149 1881 24207034 YER133W GLC7 SGTC_2598 perillyl alcohol 100 µM 0.284701417465184 0.384832602815139 no 1257 0.387936452295599 1859 10819 An apoptosis inducer. SGTC_770 0389-1121 67.2 µM 0.282545474179784 0.385687661774856 no 1258 0.388762641481077 1918 6753108 SGTC_1668 st014914 51.6 µM 0.282357064617495 0.385762412510451 no 1259 0.3888348667682 1836 2839556 SGTC_1174 0739-0097 51.1 µM 0.282015685710849 0.385897864023545 no 1260 0.388965741407189 1810 728447 SGTC_2489 cantharidin 73.42 µM 0.281981607305419 0.385911386336434 no 1261 0.388978806758136 1734 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2343 7990716 14.84 µM 0.281968816649512 0.385916461705084 no 1262 0.388983710611779 1848 6456862 SGTC_1455 4262-0120 131 µM 0.281110446251892 0.386257110107663 no 1263 0.389312844578538 1893 1529587 SGTC_558 k064-0027 21.3 µM 0.280738718906658 0.38640465911213 no 1264 0.38945540455428 1866 5088526 SGTC_1449 4112-4002 201 µM 0.280630569132812 0.386447589875041 no 1265 0.389496883525986 1762 2059539 SGTC_1102 cgs 12066b 26.1 µM 0.277925355496193 0.38752189312539 no 1266 0.390534829757308 1844 6438352 A 5-HT1B full agonist. SGTC_138 0850-0259 40.9225 µM 0.277397489121514 0.387731621883931 no 1267 0.390737454699909 1871 6813004 SGTC_2589 lobaric acid 100 µM 0.276737253394065 0.387993988959834 no 1268 0.390990932240029 1748 73157 A novel microtubule depolymerizer. SGTC_2182 6325192 200 µM 0.275921878531178 0.38831807639743 no 1269 0.391304034669795 1923 736248 SGTC_697 0508-1955 564 µM 0.275255795254842 0.388582882567685 no 1270 0.391559861698878 1943 6243113 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.273532419219829 0.389268263089592 no 1271 0.392221987616927 1822 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.272507251253037 0.389676132371491 no 1272 0.392616008243345 1957 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1035 k081-0041 55.2 µM 0.27223243140232 0.389785491788272 no 1273 0.39272165326199 1942 731709 SGTC_404 fumagillin 50 µM 0.272220751151219 0.389790139918994 no 1274 0.39272614350707 1844 12015870 A methionine aminopeptidase binder. SGTC_208 k072-0098 12.366 µM 0.271955024332739 0.389895889589975 no 1275 0.392828300863804 1845 5948901 SGTC_2791 5663188 71.43 µM 0.271774626828715 0.389967685922632 no 1276 0.392897657996737 1914 54690634 SGTC_545 4218-0007 221 µM 0.271721494999148 0.389988832554636 no 1277 0.392918086152586 1833 2840508 SGTC_837 0091-0265 12.5 µM 0.2716295224538 0.390025438680862 no 1278 0.392953448505874 1809 759367 SGTC_1944 st076371 56.9 µM 0.271297652229736 0.390157534937053 no 1279 0.393081056015755 1771 24208455 SGTC_1550 gossypolone 36.6 µM 0.270437733562578 0.390499872397736 no 1280 0.393411757000063 1883 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1424 4048-1941 275 µM 0.268426587781401 0.391300849588864 no 1281 0.394185488059612 1957 X1424 SGTC_1418 3966-3099 2.4 µM 0.267670030751264 0.391602282425738 no 1282 0.394476660134145 1905 740335 SGTC_2166 5933061 31.504 µM 0.266884046565755 0.391915508782052 no 1283 0.394779220134839 1929 2877375 SGTC_1074 carmofur 3.8 µM 0.266798429973153 0.391949632499511 no 1284 0.394812181576588 1846 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3332 9141069 11.198 µM 0.266569160821612 0.392041015091038 no 1285 0.394900451372684 1769 17332883 SGTC_1780 st038448 24.544 µM 0.266551328227856 0.392048123094289 no 1286 0.394907317238678 1912 728868 YDL195W SEC31 SGTC_1870 st057514 26.5 µM 0.265001925468862 0.39266584637389 no 1287 0.395503989260368 1809 5393161 SGTC_2771 fluoxetine 41.05 µM 0.264885913811633 0.392712109357542 no 1288 0.395548675003512 1920 3386 A selective serotonin reuptake inhibitor. SGTC_958 1222-0007 33 µM 0.263964631641048 0.393079550874496 no 1289 0.395903586138779 1895 7312461 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.263767509361856 0.393158182939586 no 1290 0.395979535973771 1859 88881 An O-methylated flavonoid and antioxidant. SGTC_901 1112-0062 60.1 µM 0.262313772562225 0.393738212874298 no 1291 0.396539772363404 1839 1908457 SGTC_453 enantio-paf c16 10 µM 0.261039078686264 0.394247000159163 no 1292 0.397031185631019 1879 13871343 A lipid and platelet activating factor SGTC_2763 lisinopril 49.32 µM 0.260354430531657 0.394520348398901 no 1293 0.397295195137805 1971 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2259 7964009 200 µM 0.260298606221379 0.39454263874793 no 1294 0.397316723816975 1893 313134 SGTC_1495 4469-0029 237 µM 0.259983658396352 0.394668402200161 no 1295 0.397438189496382 1818 793680 SGTC_2734 clemastine 41.6 µM 0.259448525510599 0.394882114059658 no 1296 0.397644596575711 1889 26987 Clemastine is a selective histamine H1 antagonist. SGTC_816 0325-0417 81.3 µM 0.258878877877261 0.395109644562794 no 1297 0.397864347891584 1823 68101 SGTC_343 4130-2827 29.8 µM 0.258800272163483 0.395141044321877 no 1298 0.397894673935998 1794 1118244 SGTC_706 4262-0057 46.9 µM 0.256267676552904 0.39615307571901 no 1299 0.39887207720766 1812 883298 SGTC_2575 plumbagin 510 nM 0.255716462342171 0.396373435292453 no 1300 0.399084891301551 1769 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2597 laccaic acid a 100 µM 0.2554724325266 0.396471001965186 no 1301 0.399179116497288 1844 5491415 A textile dye. SGTC_1705 st027868 56.3335 µM 0.254919562731751 0.396692071331893 no 1302 0.399392613219034 1957 292948 SGTC_1346 1488-2224 62.4 µM 0.254761988499309 0.39675508472138 no 1303 0.399453467746459 1965 3722427 SGTC_1614 st002383 48.6 µM 0.253519268600854 0.397252138455947 no 1304 0.399933486608967 1952 1947235 SGTC_960 1222-0186 7.7 µM 0.253123113899544 0.397410624551109 no 1305 0.40008653902368 1917 3126296 SGTC_2045 5106652 78.05 µM 0.252378700112831 0.397708481366706 no 1306 0.400374181118172 1945 673349 SGTC_2479 5617353 43.85 µM 0.251630261670145 0.39800800866622 no 1307 0.400663432827427 1924 2731746 SGTC_1725 st036284 20.55 µM 0.25115790586738 0.398197077825372 no 1308 0.400846013932641 2002 707914 SGTC_1879 gemcitabine 100 µM 0.250859494703757 0.398316534744924 no 1309 0.4009613708624 1892 60750 A nucleoside analog which inhibits DNA replication. SGTC_575 k072-0246 11.9 µM 0.250630418394621 0.398408242707705 no 1310 0.401049930847826 1864 6796779 SGTC_1833 st055984 71 µM 0.249745246786866 0.398762663270683 no 1311 0.401392182398056 1848 676288 SGTC_2147 5545932 89.7195 µM 0.249220691176022 0.398972733485577 no 1312 0.401595037517871 1872 797404 SGTC_1261 0712-0010 12.7 µM 0.247160828734972 0.399797934768792 no 1313 0.402391879551234 1966 2840123 SGTC_2802 7925815 54.55 µM 0.246976582230162 0.399871767611207 no 1314 0.402463173721022 1831 1262923 SGTC_2703 st077852 53.4 µM 0.245588970213872 0.400427938250247 no 1315 0.403000214141897 1885 6281836 SGTC_608 k048-0125 159 µM 0.244596567317597 0.40082582853119 no 1316 0.403384411112688 1978 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1215 3852-0577 11.2 µM 0.24377343326752 0.401155930895139 no 1317 0.40370314844384 1968 2884876 SGTC_2180 6301957 200 µM 0.241544413204135 0.402050190968147 no 1318 0.404566599253614 1991 845462 SGTC_1607 st000305 50.6 µM 0.240757530840341 0.402366002888289 no 1319 0.404871523480674 1977 5457690 SGTC_116 0155-0182 31.788 µM 0.240273952365945 0.402560116704909 no 1320 0.405058943305533 1852 771486 SGTC_2336 9001819 198.65 µM 0.239766705406223 0.402763757135072 no 1321 0.405255559693785 1941 2989602 SGTC_93 0109-0045 59.227 µM 0.238418787235485 0.403305023257579 no 1322 0.405778148696877 2005 88733 SGTC_3304 9125678 46.087 µM 0.238352387000598 0.403331691541052 no 1323 0.405803896471899 1853 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_381 3461-2219 42.7 µM 0.238193245866195 0.403395609121793 no 1324 0.405865607703162 1987 2883159 SGTC_1120 ficusin 1.78878 µM 0.237567988254219 0.403646763094314 no 1325 0.406108090702335 1959 6199 A DNA cross-linker. SGTC_549 1661-1316 519 µM 0.234452258049177 0.404898882483595 no 1326 0.407316946434444 1993 2857282 SGTC_2255 7941087 197.44 µM 0.232701632770967 0.405602835117218 no 1327 0.407996550625204 2009 935561 SGTC_807 1315-0151 48 µM 0.232420837340643 0.405715775645146 no 1328 0.40810558307014 2029 4011080 SGTC_1712 st032288 53.4 µM 0.230252079900667 0.406588349202755 no 1329 0.408947947450992 1915 2883011 SGTC_2653 dihydrofissinolide 100 µM 0.227584995268779 0.407662054545468 no 1330 0.409984442954983 1943 6857746 SGTC_1547 harmine 94.2 µM 0.227436046839067 0.407722038203569 no 1331 0.4100423466433 1912 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_99 0109-0120 622.8 µM 0.227379935320962 0.407744635673663 no 1332 0.410064160499529 1983 759414 SGTC_33 0986-0033 35.816 µM 0.225300216371208 0.40858240486653 no 1333 0.410872865678458 1986 2848082 SGTC_1609 st001574 46.4 µM 0.223383553125721 0.409354860821081 no 1334 0.411618501824227 1854 3960012 SGTC_2212 7123476 200 µM 0.222984487253421 0.409515737217983 no 1335 0.411773789971197 1989 1085715 SGTC_3314 9135860 59.4275 µM 0.222200044217264 0.409832016040425 no 1336 0.412079079848284 2042 25252478 SGTC_1234 0326-0494 15.5 µM 0.222190286805268 0.409835950491747 no 1337 0.412082877577532 1996 1547813 SGTC_538 2922-0838 53.3 µM 0.222129854547747 0.409860318607881 no 1338 0.412106398890512 2029 777039 SGTC_1461 k072-0203 53.8 µM 0.221526290994326 0.410103712796301 no 1339 0.412341333906571 2010 5418714 SGTC_815 1582-0027 36.9 µM 0.221328506935758 0.410183479111971 no 1340 0.412418327501911 1956 3128206 SGTC_1651 st011928 86.1 µM 0.220061655168842 0.410694488460698 no 1341 0.41291156876013 1955 720198 SGTC_565 1418-0001 44.5 µM 0.219913866552016 0.410754111771777 no 1342 0.412969118357939 1999 2862145 SGTC_3287 9117173 37.0625 µM 0.219878523537556 0.410768370736753 no 1343 0.412982881374848 2036 2789709 SGTC_3099 9120367 49.47 µM 0.219553708397627 0.410899421323508 no 1344 0.413109373505391 1920 24824940 SGTC_2083 5306046 65.942 µM 0.218782420685149 0.411210646478426 no 1345 0.413409770704156 1901 539837 SGTC_2732 terfenadine 20 µM 0.218764274367106 0.411217969439962 no 1346 0.413416838850472 1983 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1836 st055642 81 µM 0.21633487687881 0.412198633104096 no 1347 0.414363362429339 1834 8571 SGTC_493 zm226600 134 µM 0.216215003783619 0.412247035972393 no 1348 0.414410079408798 1968 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2481 5478948 45.16 µM 0.216010889335705 0.412329457243569 no 1349 0.414489629739984 1890 77792 SGTC_422 cantharidin 155 µM 0.215432268620425 0.412563124888352 no 1350 0.414715156934456 1825 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2019 4016004 108 µM 0.214748263288354 0.412839390560255 no 1351 0.414981795818827 1861 45595336 SGTC_1718 roemerine 11.9335 µM 0.214200134285245 0.413060807763606 no 1352 0.415195495683754 2004 235224 An aporphine alkaloid with mutagenic activity. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.213811482050548 0.41321782094564 no 1353 0.415347035312009 1955 4620898 SGTC_1367 1812-0510 76.9 µM 0.211273872627322 0.414243340104405 no 1354 0.416336784693066 1979 1142582 YDR527W RBA50 SGTC_2871 9038510 12.99 µM 0.209987363095156 0.414763478597489 no 1355 0.416838767973574 2057 4945164 SGTC_1273 0849-0096 14.1 µM 0.207631135650206 0.415716493230354 no 1356 0.417758495696556 1920 5286025 SGTC_2557 derrustone 83.84 µM 0.206249699116028 0.416275468758136 no 1357 0.418297934003581 1856 629853 An antioxidant. SGTC_2023 5144124 124 µM 0.205632008713625 0.416525461868225 no 1358 0.418539186237239 1928 2830192 SGTC_783 0848-0141 92.7 µM 0.204704416093167 0.416900942731259 no 1359 0.418901534965044 1911 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2051 5263410 176 µM 0.204313741403075 0.417059106921305 no 1360 0.41905416618703 2066 227584 SGTC_295 k015-0027 31 µM 0.20418757163923 0.417110189471182 no 1361 0.419103461580258 1977 3887424 SGTC_111 0083-0039 52.457 µM 0.203773073063875 0.41727801800376 no 1362 0.419265417955693 2062 759313 SGTC_858 0438-0351 2.77 µM 0.20277540768102 0.417682029789085 no 1363 0.419655290217251 1922 2799119 SGTC_533 1222-0222 6.71 µM 0.202743021638482 0.417695146208964 no 1364 0.4196679475076 2035 3982874 SGTC_1481 3346-2004 36 µM 0.202585525203915 0.417758933923405 no 1365 0.419729502310512 2047 2770522 SGTC_15 0266-0086 27.098 µM 0.202412150954675 0.417829154822003 no 1366 0.419797264958211 2073 1712902 YIL048W NEO1 SGTC_3201 9113999 49.47 µM 0.20196949271747 0.418008454336533 no 1367 0.419970286982336 1986 16649224 SGTC_2450 5739737 12.93 µM 0.201824826746172 0.418067055245026 no 1368 0.420026835991055 1948 2262825 SGTC_1721 st082152 9.2685 µM 0.200309322186537 0.418681060919914 no 1369 0.420619336123124 1991 5296051 SGTC_1160 4092-0570 10.5 µM 0.200263653278587 0.418699566731125 no 1370 0.420637193591966 1868 4994975 SGTC_1380 2291-0730 164 µM 0.199932936807265 0.418833583985804 no 1371 0.420766515308302 1892 2999191 SGTC_3224 9130643 49.47 µM 0.198873131711341 0.419263115457636 no 1372 0.421180993738563 1983 17644395 SGTC_2917 7979103 53.79 µM 0.198399179765624 0.419455235985022 no 1373 0.421366379570781 2022 2980565 SGTC_1942 st076330 65.2 µM 0.197096312782106 0.419983463219276 no 1374 0.421876084404306 2011 24208414 SGTC_1965 Pectolinarigenin 58.4 µM 0.196157272900987 0.420364271855507 no 1375 0.422243534800741 1944 5320438 An anti-inflammatory. SGTC_948 3448-0295 75.3 µM 0.193947281027753 0.421260782954567 no 1376 0.423108580807823 1967 678569 SGTC_696 1560-0013 611 µM 0.19296553529226 0.421659171786591 no 1377 0.423492979812144 2027 1650269 SGTC_2258 7960471 200 µM 0.192560309528775 0.421823634326836 no 1378 0.423651665754017 1922 2974708 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.192392733738994 0.421891649636296 no 1379 0.423717291860746 2044 165506 SGTC_2705 st078069 42.8 µM 0.192137612830855 0.421995202047458 no 1380 0.423817206488421 1956 1530061 SGTC_1264 0783-0040 158 µM 0.191815444842939 0.422125976266683 no 1381 0.423943386188237 1904 2855798 SGTC_324 1315-0088 19.6 µM 0.19072790798702 0.422567491849469 no 1382 0.424369386315541 2017 6787421 SGTC_1692 fluoroquinolonic acid 71 µM 0.19054978126018 0.422639816595479 no 1383 0.424439168945651 2026 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_121 0557-0495 61.343 µM 0.190272656355764 0.422752342728433 no 1384 0.424547739645318 1975 3104427 SGTC_1409 3909-8004 61.9 µM 0.189565563138777 0.423039485360368 no 1385 0.424824787241399 1979 2119279 SGTC_824 1304-0008 100 µM 0.189210001468261 0.423183890429903 no 1386 0.424964114606022 1958 768245 SGTC_2654 protoveratrine a 100 µM 0.188987136255605 0.423274408448195 no 1387 0.425051449448183 2006 5702278 A heart drug and vasodilator. SGTC_1612 st002233 45.4 µM 0.187794638680485 0.423758817055511 no 1388 0.425518819354957 2077 1035021 SGTC_2942 9052777 62.25 µM 0.187698526640687 0.423797864090815 no 1389 0.425556492656774 1968 6469503 SGTC_1401 3807-4679 7.6 µM 0.185715124942515 0.424603818868083 no 1390 0.426334083337291 1993 3291456 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.185334534717707 0.42475850777137 no 1391 0.426483326210527 2081 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1863 st057641 20.1 µM 0.18324378348735 0.425608488714295 no 1392 0.427303370839622 2133 3921635 SGTC_950 1165-0508 94.1 µM 0.18065354767918 0.426662010994225 no 1393 0.428319761166355 1939 6148369 SGTC_256 clotrimazole 625 nM 0.180474236580755 0.426734961355485 no 1394 0.428390139262698 2083 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_448 monastrol 171 µM 0.179826796306848 0.426998384756708 no 1395 0.428644273061143 2068 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_900 1112-0045 141 µM 0.178915092208398 0.427369384105225 no 1396 0.429002186064479 2096 56211 YIL048W NEO1 SGTC_2236 dapsone 200 µM 0.178641622951513 0.427480679369305 no 1397 0.429109554884386 2103 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_639 0833-0042 114 µM 0.178320248439345 0.427611478270265 no 1398 0.429235738850174 1947 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2424 5537928 59.2 µM 0.177926333540333 0.427771811841593 no 1399 0.42939041481834 1949 5382802 SGTC_3230 9131665 49.47 µM 0.17748566761808 0.427951188424792 no 1400 0.429563461049354 2025 15943720 SGTC_2409 alverine citrate 63.97 µM 0.177204993596697 0.428065446791839 no 1401 0.429673686708381 2052 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1943 st076331 65.2 µM 0.176836202578798 0.428215585491555 no 1402 0.429818525805565 2126 24208415 SGTC_2196 6573537 42.6665 µM 0.176777248849397 0.428239587138393 no 1403 0.429841680187482 2102 2903087 SGTC_2405 ticlatone 3.52 µM 0.176161036584945 0.428490479576725 no 1404 0.430083715167594 2062 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_149 3970-0822 46.1 µM 0.17425130817503 0.429268213662008 no 1405 0.430833982086618 1995 3114250 YBL034C STU1 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.174149081332404 0.42930985316442 no 1406 0.430874150578478 2030 6312947 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.174147114126129 0.429310654463541 no 1407 0.430874923569449 2107 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1144 3486-0183 12.5 µM 0.173135062442819 0.429722930474436 no 1408 0.431272632628533 2001 6744069 SGTC_380 3970-0968 6 µM 0.172887676442397 0.429823718933278 no 1409 0.431369859280287 1985 2891601 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.17235481296932 0.430040830367832 no 1410 0.43157929725907 1996 5379071 SGTC_1276 0871-0068 94.2 µM 0.172096273733399 0.430146177968101 no 1411 0.431680921094741 2074 3414906 SGTC_872 0588-0139 234 µM 0.171679952092815 0.43031582798985 no 1412 0.43184457384951 2099 2047100 SGTC_3094 9117742 49.47 µM 0.170904529094221 0.430631845181828 no 1413 0.432149417679218 2109 17149698 SGTC_806 3966-4455 5.86 µM 0.170395111595675 0.430839478238767 no 1414 0.432349708154433 1939 714982 SGTC_1904 st060225 78 µM 0.170102894221924 0.430958591509091 no 1415 0.432464608714338 2081 66595 SGTC_1256 0570-0116 285 µM 0.168248786926892 0.431714506245238 no 1416 0.433193780763888 1962 410638 SGTC_2928 9011484 9.79 µM 0.167752364521395 0.43191693893506 no 1417 0.433389049461857 1988 2994751 SGTC_3059 1327-0034 3 µM 0.164553264556054 0.433221904556587 no 1418 0.43464780955407 1981 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1212 0520-0165 585 µM 0.163252545754404 0.433752698312686 no 1419 0.435159797781781 2140 5403258 SGTC_680 0417-1641 114 µM 0.161939774041602 0.43428853174636 no 1420 0.435676640513155 1991 2835990 SGTC_1930 st074634 34.3 µM 0.161109808231138 0.434627360880327 no 1421 0.436003457655739 2044 684253 YOR116C RPO31 SGTC_183 3914-0051 30.55 µM 0.160118844024533 0.435031979632321 no 1422 0.436393728652486 2135 1596232 SGTC_13 0199-0087 65 µM 0.159936715747344 0.435106351504785 no 1423 0.43646546289965 2126 4589825 SGTC_581 0958-0271 211 µM 0.158766692854304 0.435584183644368 no 1424 0.436926345580712 2010 4591145 SGTC_1003 4049-0218 100 µM 0.158465843541307 0.435707064394456 no 1425 0.437044866730156 2070 295161 SGTC_1275 0867-0008 21.1 µM 0.158376086028458 0.435743726709727 no 1426 0.437080228263404 2050 3422836 SGTC_157 1348-1695 65.819 µM 0.158112811043847 0.435851267081505 no 1427 0.437183952921094 2109 5380510 SGTC_830 4076-0286 57.8 µM 0.157639500152494 0.43604461309382 no 1428 0.437370438043934 2034 6866659 SGTC_2268 7933382 153.85 µM 0.15613931072325 0.436657536546803 no 1429 0.437961606432255 2151 935025 YOR257W CDC31 SGTC_1734 st037168 69.4 µM 0.154742473244239 0.437228370890004 no 1430 0.438512172227887 1947 708907 SGTC_973 1325-0077 65.9 µM 0.154523021896519 0.437318064218116 no 1431 0.438598680183231 2088 2835149 SGTC_1049 3226-0134 66 µM 0.154326939367811 0.43739820905591 no 1432 0.438675978606927 2112 5702385 SGTC_1803 st050068 52.4 µM 0.154096669061835 0.437492330747737 no 1433 0.438766757307835 2130 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2040 5100729 123 µM 0.152710320352271 0.438059067552609 no 1434 0.439313360883331 2058 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1895 st058434 18.3 µM 0.152668076371959 0.438076338814966 no 1435 0.439330018479469 2155 5393175 SGTC_1709 st033179 39.1045 µM 0.151617641161995 0.438505842401441 no 1436 0.439744259317933 2125 573381 SGTC_1038 k292-0204 154 µM 0.151487890599223 0.438558900050185 no 1437 0.439795431251288 2069 4454212 SGTC_51 1013-0126 23.419 µM 0.151474452453521 0.438564395244881 no 1438 0.439800731138561 2184 1627850 SGTC_3249 9135183 49.47 µM 0.148856762516715 0.439635058864568 no 1439 0.44083332975979 2077 4902779 SGTC_1636 st007707 68.9 µM 0.148459930367116 0.439797406270428 no 1440 0.440989903205679 2113 403051 SGTC_1808 st050063 61.5 µM 0.147745986963667 0.440089512059766 no 1441 0.441271618761661 2136 4011993 SGTC_2066 5222451 176 µM 0.147511227722818 0.440185569569808 no 1442 0.441364259116456 2139 2281147 SGTC_332 4112-0506 40.9 µM 0.14748287126654 0.440197172548866 no 1443 0.441375449317806 2037 2790355 SGTC_335 4077-0256 27.6 µM 0.146686148634406 0.44052319883968 no 1444 0.441689876060915 2123 3121989 SGTC_1130 3454-2858 15.9 µM 0.146415266874251 0.440634055365046 no 1445 0.441796787981686 1955 715628 YIL048W NEO1 SGTC_3046 9092212 49.47 µM 0.146024851934968 0.440793838217579 no 1446 0.441950884851297 2123 25236637 SGTC_2545 solidagenone 89.61 µM 0.146008421365614 0.440800562872734 no 1447 0.441957370193744 2128 6708572 An anti ulcer agent SGTC_1978 st071761 42 µM 0.145263484071802 0.441105466522593 no 1448 0.442251422179574 1999 5147680 SGTC_2457 5731572 11.68 µM 0.144380812030174 0.441466790333541 no 1449 0.442599883914757 2160 2865357 SGTC_2682 pyrogallin 40.03 µM 0.144093721859902 0.441584321863274 no 1450 0.442713231108296 2134 822798 An ATP competetive kinase inhibitor. SGTC_1967 st070177 51.4 µM 0.143311852956663 0.441904436366265 no 1451 0.443021947577374 2110 5729214 SGTC_250 brefeldin a 552.239 µM 0.14318280720912 0.441957274216662 no 1452 0.44307290388442 2057 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2959 9079155 11 µM 0.143092438108929 0.441994276507999 no 1453 0.443108588500503 2073 16189457 SGTC_2943 9068529 45.32 µM 0.14059923278667 0.443015336224715 no 1454 0.444093277182304 2154 3270634 SGTC_2733 amorolfine 100 µM 0.139876696998818 0.443311312379907 no 1455 0.444378706679675 2193 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1914 st062367 72.6 µM 0.139855776742346 0.443319882527154 no 1456 0.44438697141811 2047 978205 SGTC_777 1315-0167 517 µM 0.139580716595934 0.443432565539357 no 1457 0.444495638689482 1990 4221767 SGTC_3161 9100388 49.47 µM 0.138725794141629 0.443782828056698 no 1458 0.444833417201499 2084 25236368 SGTC_989 1501-0895 10.3 µM 0.138489107770023 0.44387980645582 no 1459 0.444926938704641 2178 2830112 SGTC_1980 st071811 45.7 µM 0.138116222366559 0.444032597013322 no 1460 0.445074282528074 2127 4974850 SGTC_2471 5466956 24.79 µM 0.135948746721477 0.444920888600129 no 1461 0.445930899429656 2085 724419 SGTC_2821 7996764 71.43 µM 0.135373842981682 0.4451565466909 no 1462 0.446158152007706 2086 2987135 SGTC_3005 9076496 71.4286 µM 0.134775270091741 0.445401927568852 no 1463 0.446394779511208 2188 21368410 SGTC_1910 st062352 60.4 µM 0.13453136791121 0.445501919609688 no 1464 0.446491204265089 2101 2245730 SGTC_25 0118-0223 35.662 µM 0.134224045029838 0.445627917031403 no 1465 0.4466127063843 2157 5333628 SGTC_2178 5812956 200 µM 0.133927517438014 0.445749493764505 no 1466 0.446729945266109 2183 5403383 SGTC_2902 5787006 60.46 µM 0.133597747608718 0.445884705852891 no 1467 0.446860332685208 2063 591003 SGTC_140 0062-0056 502.533 µM 0.132286326035171 0.446422476510622 no 1468 0.447378911282608 2149 3758964 SGTC_2685 mycophenolic acid 18.85 µM 0.132049612938252 0.446519555259447 no 1469 0.447472524924981 2149 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1135 dihydrocapsaicin 536.708 nM 0.131972372983292 0.446551232942399 no 1470 0.447503071876373 2066 107982 A Capsaicinoid. SGTC_1788 fluconazole 20 µM 0.131482845811945 0.446752005955323 no 1471 0.447696677910864 2011 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1303 1160-0052 261 µM 0.13116668373762 0.446881682853279 no 1472 0.447821725370372 2189 3562476 SGTC_394 menadione 8.33 µM 0.130748339761412 0.447053279363006 no 1473 0.447987195472781 2175 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2834 9001755 58.44 µM 0.130045208918615 0.447341712185823 no 1474 0.448265329408902 2027 2989575 SGTC_2386 9075165 157.42 µM 0.129495161049011 0.447567367935031 no 1475 0.44848292681927 2087 16452277 SGTC_833 3852-0053 558 µM 0.129237638602011 0.447673021705978 no 1476 0.448584807315467 2120 3123681 SGTC_1207 2099-0101 141 µM 0.129154761752846 0.447707024392723 no 1477 0.44861759560412 2166 5837381 SGTC_2142 5622915 118.518 µM 0.128483784389883 0.44798232689562 no 1478 0.448883065021674 2066 5322196 SGTC_3282 9108498 15.4605 µM 0.127242632741483 0.448491638271473 no 1479 0.449374181771833 2050 16459645 SGTC_516 3992-2719 87.3 µM 0.126584837166858 0.448761601705506 no 1480 0.449634499289361 2133 5350887 YDR037W KRS1 SGTC_298 1391-0729 10 µM 0.126498326123672 0.448797108148855 no 1481 0.449668736981729 2090 3237558 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.125573466898045 0.449176720653962 no 1482 0.450034783507727 2168 91467 include heat shock SGTC_3083 9117465 49.47 µM 0.124878670268704 0.449461933586699 no 1483 0.450309802414158 2019 16420915 SGTC_683 panaxydol 45 µM 0.124598515835494 0.449576943940038 no 1484 0.450420701716513 2145 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1328 1441-0025 69.2 µM 0.123946318867604 0.449844703387265 no 1485 0.450678889263406 2163 4562601 SGTC_2777 climbazole 1.536 µM 0.123111273631656 0.450187564506476 no 1486 0.451009492063342 2206 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_526 4469-0568 170 µM 0.122260777147395 0.45053680797098 no 1487 0.451346247104359 2064 2901964 SGTC_134 0269-0018 6.916 µM 0.122099021719564 0.450603234724187 no 1488 0.451410298318964 2062 4378915 SGTC_3259 9138485 49.47 µM 0.121457229720397 0.450866807712924 no 1489 0.451664444789455 2177 17646153 SGTC_53 0973-0023 39.979 µM 0.120833224381748 0.45112309680056 no 1490 0.451911566826483 2231 674768 SGTC_694 1315-0438 43.2 µM 0.120092900101301 0.451427186379794 no 1491 0.45220477829277 2135 6793154 SGTC_862 0452-0056 10.2 µM 0.119095593121557 0.451836877115073 no 1492 0.452599811037714 2176 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2256 7954252 200 µM 0.118878587991592 0.451926028986083 no 1493 0.452685772879244 2074 2972920 SGTC_633 0437-0093 97.7 µM 0.118689014104444 0.452003913307557 no 1494 0.452760870248175 2168 2831118 SGTC_3044 9093193 49.47 µM 0.118324142826501 0.452153821807279 no 1495 0.45290541428077 2060 25236277 SGTC_363 0455-0021 3.06 µM 0.117791321655142 0.452372745291534 no 1496 0.453116502995808 2148 4597466 SGTC_2135 5326629 150.42 µM 0.116180523896592 0.453034671382391 no 1497 0.453754735947383 2089 5020077 SGTC_2224 6650123 117.647 µM 0.116009219561653 0.45310507328621 no 1498 0.453822617490091 2161 2908370 SGTC_2807 7945238 51.95 µM 0.114747830435012 0.453623518698405 no 1499 0.454322500541303 2130 17148797 SGTC_2683 piperine 63.03 µM 0.114267635866134 0.453820905000165 no 1500 0.454512818629442 2130 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_300 r073-0011 5.04 µM 0.113997186158234 0.453932079686252 no 1501 0.454620012012168 2222 2735780 SGTC_176 1486-1328 72.834 µM 0.112577827958213 0.454515599098301 no 1502 0.455182632004434 2117 22310231 SGTC_1743 st037606 46.3785 µM 0.112041371865 0.454736169864923 no 1503 0.455395301532886 2134 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3188 9110789 49.47 µM 0.111390663930017 0.455003735459931 no 1504 0.45565328154668 2189 849217 SGTC_2419 paclitaxel 166.5 µM 0.110269363447768 0.455464852558808 no 1505 0.456097876746404 2049 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_435 c-PAF 6.7 µM 0.107906899598087 0.456436574121378 no 1506 0.45703477199761 2218 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2630 antimycin a 100 µM 0.105440044845097 0.457451511470244 no 1507 0.458013320975969 2193 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1200 1643-0193 18.4 µM 0.105298937291311 0.457509575766067 no 1508 0.45806930310378 2231 5403974 SGTC_3078 9116413 49.47 µM 0.105225622597048 0.45753974436097 no 1509 0.458098389845199 2196 17177322 SGTC_2473 5854593 8.94 µM 0.103960641753549 0.45806031542774 no 1510 0.458600291300766 2081 2872951 SGTC_1025 k007-0731 70 µM 0.103816810551208 0.458119510115574 no 1511 0.458657362833329 2119 6256118 SGTC_535 2293-4129 48.2 µM 0.10356583534337 0.45822280285519 no 1512 0.458756950634578 2216 396118 YIL048W NEO1 SGTC_1661 st013063 9.66 µM 0.103552691732615 0.458228212389871 no 1513 0.458762166134638 2209 721395 SGTC_3204 9114183 49.47 µM 0.103381748191902 0.458298568571769 no 1514 0.458829998677533 2139 17027248 SGTC_1153 4055-0057 267 µM 0.103380724224125 0.45829899001581 no 1515 0.458830405004415 2077 882706 SGTC_2462 5162487 171.77 µM 0.101293427692907 0.459158175044837 no 1516 0.459658766651197 2234 2259986 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.100608938667411 0.459439970103076 no 1517 0.459930450342099 2243 229346 A bile salt which induces apoptosis. SGTC_3156 9099931 49.47 µM 0.100004797669127 0.459688703879167 no 1518 0.460170258276446 2155 18111053 SGTC_2310 7668677 200 µM 0.0994266185095503 0.459926763560053 no 1519 0.460399774479166 2182 2197143 SGTC_2888 9058547 12.99 µM 0.0993004896119738 0.459978697826446 no 1520 0.460449844842802 2177 16476514 SGTC_2185 6113692 200 µM 0.0988357449624185 0.460170064875196 no 1521 0.460634343525936 2142 874150 SGTC_1540 guanosine 70.6 µM 0.0960725301719968 0.461308057755744 no 1522 0.461731484057299 2214 6802 Guanosine is a purine nucleoside SGTC_1231 0242-0792 125 µM 0.0952137234929518 0.461661810733191 no 1523 0.462072534869527 2153 3707635 SGTC_97 0535-0701 19.132 µM 0.0944562069551306 0.461973866249915 no 1524 0.462373384320588 2234 2832013 YGL099W LSG1 SGTC_1237 0330-0133 46.1 µM 0.0943074150799975 0.462035163147588 no 1525 0.462432479893966 2194 X1237 YHR072W ERG7 SGTC_2809 7964133 12.99 µM 0.0937413461837119 0.462268371389138 no 1526 0.462657312680997 2152 1253665 SGTC_3294 9122953 26.2835 µM 0.0936859318028327 0.462291201623631 no 1527 0.462679322958122 2236 16459826 SGTC_2037 5169046 200 µM 0.0932480168635302 0.462471623067033 no 1528 0.462853264297131 2172 5718022 SGTC_589 1227-0070 34.1 µM 0.0931436186442954 0.462514636391001 no 1529 0.462894732683151 2167 2841384 SGTC_1908 st060353 56.5 µM 0.092557127608076 0.46275628589717 no 1530 0.463127702345635 2250 4227716 SGTC_640 3381-0960 37.1 µM 0.0925013103965071 0.462779284752604 no 1531 0.463149875070223 2221 1745025 SGTC_3081 9117243 49.47 µM 0.0921664988516883 0.462917242700033 no 1532 0.463282877381747 2217 45595589 SGTC_607 4491-0986 66.8 µM 0.0914625978180159 0.463207297230278 no 1533 0.463562512124045 2237 698981 YDR232W HEM1 SGTC_753 1322-0200 289 µM 0.0913413039120758 0.463257280450926 no 1534 0.463610699683396 2172 5403907 SGTC_6 0844-0013 19.835 µM 0.0911397500731231 0.463340338750288 no 1535 0.463690774033932 2249 1584900 SGTC_1270 0831-1170 17.3 µM 0.0907499990818318 0.463500955723261 no 1536 0.463845620491056 2235 6764716 SGTC_2242 6630449 61.2675 µM 0.0901686831101029 0.463740527961177 no 1537 0.464076585092169 2174 691249 YDR170C SEC7 SGTC_2382 9035899 200 µM 0.0897594435655814 0.463909191865077 no 1538 0.464239188696146 2225 6462679 SGTC_1939 st074455 53.6 µM 0.089330192904574 0.464086110116056 no 1539 0.464409749757144 2254 1644229 SGTC_1891 st059073 26.2 µM 0.0891651213017893 0.464154147266051 no 1540 0.464475342051802 2270 688754 SGTC_2522 biochanin a 4.94 µM 0.0887173431049046 0.46433871215916 no 1541 0.464653274540378 2216 5280373 A possible chelator. SGTC_81 0411-0046 9.971 µM 0.0879631302301974 0.464649600403711 no 1542 0.46495299016283 2232 12925265 SGTC_3319 9138450 16.7555 µM 0.0872015844974129 0.464963533166027 no 1543 0.465255639954769 2123 2029690 SGTC_2966 9084041 48.03 µM 0.0869669387262325 0.465060265832164 no 1544 0.46534889579165 2206 17741380 SGTC_2558 carylophyllene oxide 100 µM 0.0858331452265337 0.465527700936595 no 1545 0.465799528808629 2275 6708694 An oxygenated terpenoid and antifungal agent. SGTC_945 3381-0768 11.3 µM 0.0856169625146288 0.46561683315753 no 1546 0.465885456918163 2252 1126236 YIL048W NEO1 SGTC_234 nsc-17383 10.7 µM 0.0854257342829557 0.465695678073869 no 1547 0.465961467469169 2242 408974 SGTC_2267 7931562 200 µM 0.0847304806072205 0.46598234800258 no 1548 0.4662378315375 2138 934880 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0825228333346602 0.466892730740005 no 1549 0.467115480940921 2215 390807 SGTC_3280 9140961 49.47 µM 0.0818938412623197 0.467152144457225 no 1550 0.467365565975436 2108 4901226 SGTC_2438 5259590 200 µM 0.0816925704985833 0.467235157035686 no 1551 0.467445593248164 2244 1201127 SGTC_677 0929-0063 136 µM 0.0806320275440127 0.467672593273968 no 1552 0.467867297413465 2263 1539583 SGTC_1124 fisetin 1.16336 µM 0.0795975465962362 0.46809931747976 no 1553 0.468278673279759 2115 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2665 lovastatin 100 µM 0.0792391475458316 0.468247165945288 no 1554 0.468421203615025 2204 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2139 5578692 56.4705 µM 0.0788887449693232 0.468391719902095 no 1555 0.468560557776924 2280 650991 YMR113W FOL3 SGTC_1240 0356-0016 42.1 µM 0.0780380441686768 0.468742682589296 no 1556 0.468898895191603 2217 4305613 SGTC_194 1486-1323 56.904 µM 0.0778526563625382 0.468819168885056 no 1557 0.468972629898305 2162 5178754 SGTC_876 0720-0963 56.8 µM 0.0774528894455345 0.468984106464688 no 1558 0.469131633706586 2275 765861 SGTC_2838 9002687 71.43 µM 0.0771576767680133 0.469105910018298 no 1559 0.469249055138706 2181 6457060 SGTC_211 3455-0679 143.504 µM 0.0734713055204918 0.470627131673666 no 1560 0.47071553861208 2175 748649 SGTC_1647 st011722 22.4 µM 0.0731845574603184 0.470745479673418 no 1561 0.470829627397157 2252 2854783 SGTC_1052 3253-3998 198 µM 0.0723158865965263 0.471104017299628 no 1562 0.471175261060886 2275 5450317 SGTC_3211 9128781 49.47 µM 0.0714706164548216 0.471452918934 no 1563 0.471511604705105 2055 17194361 SGTC_1373 2887-0003 58.5 µM 0.069958232855543 0.472077239077033 no 1564 0.472113451750031 2220 776948 SGTC_2323 6148992 148.28 µM 0.0694318640762821 0.472294543134795 no 1565 0.472322933123039 2211 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_2366 9070441 60.58 µM 0.0692393564577795 0.47237401930096 no 1566 0.472399548169114 2261 6837235 SGTC_1527 coumarin 137 µM 0.0691125598506494 0.472426367483326 no 1567 0.47245001180995 2229 323 A hepatotoxic, DNA x-linker. SGTC_2243 6634756 200 µM 0.0682710182574613 0.472773811305648 no 1568 0.472784947182795 2277 885676 SGTC_1597 7-benzyloxygramine 47.5 µM 0.0679405449543647 0.472910258141018 no 1569 0.472916481547 2271 260807 SGTC_2058 5236698 133 µM 0.067040640754969 0.473281829425976 no 1570 0.473274674657469 2242 766665 SGTC_2436 5633522 8.09 µM 0.0664564559907491 0.473523052326016 no 1571 0.473507212058831 2290 5724242 SGTC_1335 1486-0900 202 µM 0.0652603286565752 0.474016990137838 no 1572 0.473983364062677 2299 X1335 SGTC_2787 5284540 71.43 µM 0.0643153589431453 0.474407241316888 no 1573 0.474359562053107 2214 736958 SGTC_2794 7785382 27.27 µM 0.0635967860278052 0.474704012182229 no 1574 0.47464564547089 2318 2205081 SGTC_2125 5246583 200 µM 0.0634619217786767 0.474759712733674 no 1575 0.474699340057431 2291 835267 SGTC_793 0488-0545 106 µM 0.0631770977573771 0.474877350088403 no 1576 0.474812740841301 2141 292548 SGTC_1702 st027038 51 µM 0.0627884177315487 0.475037885340337 no 1577 0.474967494491045 2201 5521182 SGTC_3225 9130819 49.47 µM 0.0625984238064863 0.475116359392041 no 1578 0.47504314228897 2279 4547121 SGTC_1505 k297-0037 20.6 µM 0.0617131378441087 0.475482025743776 no 1579 0.475395638713092 2224 4089396 SGTC_1142 3253-1408 9.78 µM 0.0616540217670919 0.475506444310574 no 1580 0.475419177791542 2304 256655 SGTC_305 1682-2595 20.8 µM 0.0613303696754212 0.47564013410984 no 1581 0.475548052407852 2222 226033 SGTC_147 4466-0538 29.23 µM 0.0609769115310845 0.475786138919919 no 1582 0.475688798380414 2192 6742687 YHR072W ERG7 SGTC_1306 1185-0270 9.02 µM 0.0604814248629975 0.475990817666489 no 1583 0.475886104787849 2283 1548076 SGTC_1387 3342-1166 1.8 µM 0.0589236832709378 0.476634340368788 no 1584 0.476506447149898 2228 3418228 SGTC_2188 6126565 140.678 µM 0.0583240859128429 0.4768820579362 no 1585 0.476745241192039 2294 874518 SGTC_2580 diallyl disulphide 81.36 µM 0.0574260353819481 0.477253095086038 no 1586 0.477102911991647 2257 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2296 7971656 126.45 µM 0.0573980333995068 0.477264664659909 no 1587 0.477114064770653 2250 666570 SGTC_1483 3453-0561 55.9 µM 0.0567367241091266 0.47753790324514 no 1588 0.477377459755488 2287 4546991 SGTC_83 0170-0301 39.027 µM 0.0563186271973251 0.477710657233024 no 1589 0.477543990013473 2298 3089716 SGTC_499 genistein 192 µM 0.0546844401547901 0.478385928906868 no 1590 0.478194932885209 2311 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2335 9018011 154.17 µM 0.0542250104751705 0.478575783702656 no 1591 0.47837794725859 2271 6458208 SGTC_1534 6-azauridine 81.6 µM 0.0539325459689632 0.478696644318072 no 1592 0.478494453228915 2320 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2105 5350118 200 µM 0.0532948137887695 0.478960193174239 no 1593 0.478748506164093 2260 2133313 SGTC_1925 st057770 10.1 µM 0.0520123862386229 0.479490196223484 no 1594 0.479259411991278 2253 5989122 SGTC_1047 2043-3044 82 µM 0.0513461298449788 0.479765561762477 no 1595 0.479524855129049 2290 669592 SGTC_1192 1488-0095 21.4 µM 0.0511287058977153 0.479855425754335 no 1596 0.479611480951337 2228 915875 SGTC_772 k072-0172 35.3 µM 0.0507897187890079 0.479995535337047 no 1597 0.479746541761221 2227 5861980 SGTC_2679 rapamycin 1 nM 0.0500746714628106 0.480291085581952 no 1598 0.480031441827283 2272 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2881 9058953 51.95 µM 0.0499921627294689 0.480325189586292 no 1599 0.480064316874986 2305 17122249 SGTC_2285 7945142 200 µM 0.0498416548709719 0.480387400591649 no 1600 0.480124286064109 2280 2970608 SGTC_2041 5107442 45.335 µM 0.0496087466891834 0.480483671935377 no 1601 0.480217088183061 2316 793005 SGTC_369 0957-0393 4.5 µM 0.049197985763643 0.480653460524385 no 1602 0.480380758226193 2275 6997992 SGTC_1975 st070967 30.8 µM 0.048788503746057 0.480822723968569 no 1603 0.480543921973302 2327 261391 SGTC_3132 9126706 49.47 µM 0.0474969006119225 0.481356643415412 no 1604 0.481058600251534 2265 850858 SGTC_1111 tnp00062 510.699 nM 0.0474635184061146 0.481370443309781 no 1605 0.481071902821929 2314 676306 SGTC_3041 9091929 49.47 µM 0.0467234354730999 0.481676392436094 no 1606 0.481366825967173 2290 25236887 SGTC_1512 0259-0544 12.2 µM 0.0462160974871541 0.481886131411406 no 1607 0.481569006122286 2230 18476 SGTC_2452 5863136 48.41 µM 0.0453960374738414 0.482225163609985 no 1608 0.48189581968558 2302 2184096 SGTC_1999 st074831 12.5 µM 0.0452806001517013 0.48227288916604 no 1609 0.481941825206159 2193 17112523 SGTC_2235 salicylic acid 500 µM 0.0448596403104609 0.482446929848826 no 1610 0.482109593402294 2329 338 A COX inhibitor and kinase inhibitor. SGTC_712 r015-0009 80.6 µM 0.0448258149475168 0.482460914675859 no 1611 0.482123074208829 2296 6813872 YLR060W FRS1 SGTC_3177 9107506 49.47 µM 0.0441718729629541 0.482731286004427 no 1612 0.482383701143144 2325 8897194 SGTC_1447 4239-0816 81.9 µM 0.0437630821760492 0.482900303981423 no 1613 0.482546627514945 2274 1341554 SGTC_2287 7945887 168.79 µM 0.0432054212331886 0.483130878521725 no 1614 0.482768891803371 2304 1245853 SGTC_593 1203-0218 61.7 µM 0.0431107120346135 0.483170038236829 no 1615 0.482806640135261 2349 3666956 SGTC_2506 ethyl hematommate 54.16 µM 0.042847728576304 0.483278775698182 no 1616 0.482911458499861 2158 3940691 An allergen. SGTC_2786 7743617 45.45 µM 0.0428256536002402 0.483287903237158 no 1617 0.482920257064843 2269 583674 SGTC_1785 bathophenanthroline 24 µM 0.0425303000238685 0.483410026578506 no 1618 0.483037978835077 2262 72812 An iron chelator. SGTC_1190 1486-1332 13 µM 0.0425043074985121 0.483420774090497 no 1619 0.483048338984053 2305 4150046 SGTC_3028 9087778 49.47 µM 0.0418704121601361 0.48368288383552 no 1620 0.483301001690409 2322 17217395 SGTC_3166 9102297 49.47 µM 0.0417533338538416 0.483731295386007 no 1621 0.483347668366942 2281 25237072 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0405062323915711 0.484246983075601 no 1622 0.483844769195576 2332 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_361 000s-0510 1.45 µM 0.0396710552961127 0.484592351114048 no 1623 0.484177689015783 2287 660 SGTC_1759 st043059 70 µM 0.0392476994173785 0.484767424509742 no 1624 0.484346452137377 2308 669426 SGTC_944 3370-0224 231 µM 0.0388878266013047 0.484916247609108 no 1625 0.484489911096722 2318 4580514 SGTC_931 2812-0076 566 µM 0.0386122308213971 0.485030219901414 no 1626 0.484599775390135 2340 3450959 SGTC_991 3996-0057 64.7 µM 0.0379764451673923 0.485293152917996 no 1627 0.484853231255398 2307 715343 SGTC_3010 9080089 71.4286 µM 0.0379267593553214 0.48531370105804 no 1628 0.484873038756818 2343 17027233 SGTC_2646 retinol 96.75 µM 0.0378350177009051 0.485351641978678 no 1629 0.484909612131514 2320 445354 A vitamin A analog and teratogen. SGTC_3214 9129694 49.47 µM 0.0374596633970876 0.485506875872373 no 1630 0.485059250751903 2320 17158655 SGTC_1945 st075991 56.6 µM 0.0371668889766419 0.485627959034466 no 1631 0.485175969565466 2236 1084980 SGTC_1608 st001473 40.5 µM 0.0370128113579029 0.485691681682334 no 1632 0.485237395377026 2298 7292267 SGTC_657 3534-0529 86.7 µM 0.0368425896251467 0.485762081556543 no 1633 0.485305257736981 2325 1049549 SGTC_2907 7721985 69.9 µM 0.0346200164925592 0.486681327652635 no 1634 0.48619137010664 2321 3267881 SGTC_2704 st078022 71.1 µM 0.0341544404901772 0.486873896888908 no 1635 0.486376998273669 2355 54697681 SGTC_3034 9090421 49.47 µM 0.0340021176548066 0.486936900571029 no 1636 0.486437731017318 2335 17173761 SGTC_1057 3448-5381 134 µM 0.0330627184929943 0.487325461449008 no 1637 0.486812286408808 2338 5497911 SGTC_2183 6420625 130.508 µM 0.0322041828691065 0.4876805855148 no 1638 0.487154610231836 2345 2897619 SGTC_196 k015-0023 18.111 µM 0.0301664793715911 0.488523498333003 no 1639 0.487967140972153 2329 5211998 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.029470516340007 0.488811401101381 no 1640 0.488244666638044 2293 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_168 3970-0862 530.542 µM 0.0289378440888636 0.489031758441584 no 1641 0.488457081516154 2305 3135186 SGTC_3136 9095672 49.47 µM 0.0287615160577087 0.489104703053432 no 1642 0.488527396954909 2369 17217380 SGTC_16 erodoxin 22.806 µM 0.0268716659524074 0.48988653183713 no 1643 0.489281046324117 2355 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2161 5662504 8.5105 µM 0.0267230085300705 0.489948032927078 no 1644 0.489340330765308 2324 2859334 SGTC_34 0469-0683 81.75 µM 0.0266166928771072 0.489992016942377 no 1645 0.489382729492939 2323 3690923 SGTC_246 cycloheximide 667 µM 0.024973557571934 0.490671816171066 no 1646 0.49003802751475 2331 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2007 4011539 71.82 µM 0.0248822144541409 0.490709607530745 no 1647 0.490074456826112 2350 45595301 SGTC_2060 5238662 140 µM 0.0241363157144549 0.491018211074803 no 1648 0.490371938000881 2323 790130 SGTC_186 3455-3465 67.277 µM 0.0210081680625046 0.492312488004148 no 1649 0.491619569971485 2379 755278 SGTC_3298 9116858 71.43 µM 0.0183640195350381 0.493406573063048 no 1650 0.492674227925496 2362 2506942 SGTC_2018 5133068 143 µM 0.0180509820282999 0.493536103897419 no 1651 0.492799091123169 2372 785362 SGTC_891 0929-0073 133 µM 0.0176715959651169 0.493693089810683 no 1652 0.492950420122619 2354 5603632 SGTC_1671 st016596 74.5 µM 0.016370344330709 0.494231541152309 no 1653 0.493469469187224 2375 2829167 SGTC_2423 st077119 87.2 µM 0.0163598576736226 0.494235880521954 no 1654 0.493473652197938 2362 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_390 dec-rvkr-cmk 16.7 µM 0.0156291065902984 0.494538266339911 no 1655 0.493765142407639 2369 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2455 5377712 9.75 µM 0.0148953317694447 0.494841906542224 no 1656 0.494057842109369 2347 2243908 SGTC_1141 3253-0389 52.6 µM 0.0142869308968944 0.495093668564003 no 1657 0.494300533101154 2363 5402031 SGTC_402 epigallocatechin gallate 10 µM 0.014083177900196 0.495177983918382 no 1658 0.494381810608585 2358 65064 An antioxidant. SGTC_811 0416-0114 265 µM 0.0122215927911057 0.495948338940051 no 1659 0.495124411277693 2345 6612453 SGTC_3276 9139060 49.47 µM 0.0119963710335015 0.49604154054799 no 1660 0.495214255172046 2389 4870619 SGTC_1646 st011709 75.6 µM 0.0113077817070921 0.496326494941684 no 1661 0.495488943914757 2380 5757843 SGTC_2673 kobusone 100 µM 0.010829938123456 0.496524238920574 no 1662 0.495679564244148 2388 6710676 An epoxy ketone and protein crosslinker. SGTC_522 1273-0010 11.6 µM 0.0106320829841359 0.49660611672458 no 1663 0.495758492479884 2364 5705015 SGTC_711 k292-0785 179 µM 0.0102654285085034 0.496757848631384 no 1664 0.495904758467071 2383 4146315 SGTC_1502 4534-4282 27.7 µM 0.00956210686928783 0.497048904148029 no 1665 0.496185329411906 2389 3278949 SGTC_349 k015-0014 24 µM 0.00938100619505463 0.497123849280664 no 1666 0.496257574887111 2383 2196908 SGTC_1749 st037932 54.2 µM 0.00937997983321087 0.497124274021641 no 1667 0.496257984328231 2376 594497 SGTC_2712 st079126 47.7 µM 0.00928830003515047 0.497162214033437 no 1668 0.496294557682641 2384 3152970 SGTC_1519 esterone 74 µM 0.00731446420445286 0.497979055636144 no 1669 0.497081976990097 2383 698 A steroid. SGTC_2939 9044578 71.43 µM 0.00718991886896573 0.498030597127883 no 1670 0.497131662083624 2393 2653634 SGTC_466 geldanamycin 89.2 µM 0.00591429245029636 0.498558500521213 no 1671 0.497640552438055 2397 5288382 HSP90 inhibitor. SGTC_675 1309-0189 238 µM 0.0056591929321827 0.498664070869507 no 1672 0.497742320717324 2391 4246530 SGTC_531 3788-1495 174 µM 0.00427432347827135 0.499237186489381 no 1673 0.498294796836705 2400 2896655 SGTC_1849 st056239 19.2 µM 0.00420321768826599 0.49926661302603 no 1674 0.498323163687876 2390 5393181 SGTC_2505 galangin 7.89 µM 0.00388577045274401 0.499397985956562 no 1675 0.498449805775585 2391 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3139 9095020 49.47 µM 0.00243107581312263 0.5 no 1676 0.499030142026615 2403 25236292 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.00155834049145329 0.499638825198657 no 1677 0.499378312342318 2403 676296 Flavone; oxidizing agent. SGTC_2975 9084847 53.72 µM 0.00111661935448026 0.499456022397312 no 1678 0.499554533420954 2395 27211724 SGTC_972 1319-0219 195 µM 0.000228728626913163 0.499088576221874 no 1679 0.499908750480782 2404 23903702 SGTC_1789 tunicamycin 25 nM 0 0.498993918899241 no 1680 0.5 2406 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1728 st035614 33.7865 µM -0.000136965022369023 0.498937237160872 no 1681 0.499945358861812 2408 15945546 SGTC_929 2805-0021 398 µM -0.000195824261245598 0.498912878802604 no 1682 0.49992187742316 2406 3098024 SGTC_276 colchicine 750 µM -0.000891918638754128 0.498624806836267 no 1683 0.4996441759915 2414 2833 A microtubule depolymerizer. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.00216913586215954 0.498096244740238 no 1684 0.499134640671257 2386 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1745 st081495 74 µM -0.00382246778815548 0.497412036869595 no 1685 0.498475059697383 2415 13842402 YBL026W LSM2 SGTC_769 0302-0231 76 µM -0.0038747499129616 0.497390400770422 no 1686 0.498454202301759 2412 571869 YER009W NTF2 SGTC_319 1348-1596 45.5 µM -0.00484561829999552 0.496988624287086 no 1687 0.498066885550374 2415 5380505 SGTC_2115 tiliquinol 12.7705 µM -0.00525859627035213 0.496817721657203 no 1688 0.49790213328086 2423 71208 A bioactive hydroxyquinoline. SGTC_756 0508-1999 28.3 µM -0.00541607675273264 0.496752551677913 no 1689 0.497839308553021 2415 6753853 SGTC_2010 4012422 159 µM -0.00570017693120245 0.496634983025833 no 1690 0.497725970731014 2432 952393 SGTC_447 ml7 120 µM -0.00654593434767591 0.49628498656633 no 1691 0.497388568673642 2417 4216 Selective myosin light chain kinase inhibitor. SGTC_320 4092-0846 5.34 µM -0.00721112596073036 0.496009714937312 no 1692 0.497123201897398 2424 1359356 SGTC_2168 5727979 200 µM -0.00742700732207374 0.495920378653704 no 1693 0.497037080001726 2414 695210 SGTC_1158 4092-0494 91.8 µM -0.0077200954823039 0.495799092888359 no 1694 0.496920158096435 2452 1148199 SGTC_548 1436-0017 110 µM -0.00840900605119767 0.495514009411879 no 1695 0.496645331485614 2418 9677137 SGTC_495 decylubiquinone 155 µM -0.00891647939743654 0.495304009350288 no 1696 0.496442886509988 2439 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2675 theaflavin digallate 100 µM -0.00902026505519281 0.495261061451039 no 1697 0.496401483688111 2437 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_85 0868-0259 160.055 µM -0.00910265606920345 0.495226966981835 no 1698 0.496368615778527 2450 83173 SGTC_2281 7943571 200 µM -0.0104408263620798 0.494673219833663 no 1699 0.495834788597517 2422 1244024 SGTC_3057 9095946 49.47 µM -0.0105089002484358 0.49464505050007 no 1700 0.495807632535923 2426 24540043 SGTC_1371 2421-0008 32.7 µM -0.0116905031051111 0.494156101375514 no 1701 0.495336270262778 2436 2827552 SGTC_496 calpeptin 138 µM -0.0117777708466551 0.494119990185665 no 1702 0.495301457867714 2455 73364 A calpain inhibitor. SGTC_2210 7115885 190.385 µM -0.0123071351279481 0.493900941512326 no 1703 0.495090287389235 2424 2927039 SGTC_1575 cyproterone acetate 48 µM -0.0123241132099502 0.493893916084763 no 1704 0.495083514628131 2437 9880 An androgen receptor antagonist and liver toxin. SGTC_1873 rapamycin 2 nM -0.0131118707435582 0.493567948904492 no 1705 0.494769270264515 2432 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2971 9092186 9.93 µM -0.0134660096908158 0.493421410690609 no 1706 0.494628001740329 2433 25236400 SGTC_2515 chrysin 20.77 µM -0.0134920716231994 0.493410626627694 no 1707 0.494617605478055 2440 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_632 0781-2353 4.65 µM -0.0141791590341325 0.493126321233125 no 1708 0.494343523499118 2458 6811515 YHR007C ERG11 SGTC_588 3970-1144 52.9 µM -0.01427504828325 0.493086644123822 no 1709 0.494305273094761 2446 1888707 SGTC_2233 sulbentine 40.3845 µM -0.014717098967464 0.492903733025011 no 1710 0.494128938916249 2421 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_3159 9100096 49.47 µM -0.0163722518524328 0.492218879799941 no 1711 0.493468708298131 2431 25236875 SGTC_1394 3474-0001 65.7 µM -0.0165326239101469 0.492152523780478 no 1712 0.493404737762227 2454 5017666 YIL048W NEO1 SGTC_631 k072-0230 41.5 µM -0.0175872066439528 0.491716181986964 no 1713 0.492984081359544 2459 5773147 SGTC_2098 5376439 882.5 nM -0.0177270367329582 0.491658326935007 no 1714 0.492928305920355 2468 2844116 SGTC_2146 5545642 200 µM -0.0185681634471232 0.49131031238146 no 1715 0.492592800172295 2434 825326 SGTC_2878 9043973 25.97 µM -0.0193289854487174 0.490995529437923 no 1716 0.492289330600351 2507 6465167 SGTC_288 1315-0019 35.1 µM -0.0194262477825813 0.490955288462732 no 1717 0.492250535827345 2457 6811474 SGTC_605 1315-0399 119 µM -0.0197627480897032 0.490816066724514 no 1718 0.492116317396777 2458 24020461 SGTC_2104 5389443 200 µM -0.0206337863158722 0.490455693522219 no 1719 0.49176889430782 2457 2244536 SGTC_1131 3454-3128 32.3 µM -0.0208114790305724 0.490382177956948 no 1720 0.491698020390339 2524 710982 SGTC_2833 9001315 45.46 µM -0.0211598141663039 0.490238064645483 no 1721 0.491559085374324 2464 2989378 SGTC_1738 st035555 74 µM -0.0213832033727467 0.490145644668935 no 1722 0.491469986135036 2462 5331140 SGTC_2143 5623677 140.463 µM -0.021877147812918 0.489941293200349 no 1723 0.491272976907888 2444 5375313 SGTC_2431 5490079 200 µM -0.0244744702686901 0.488866790609569 no 1724 0.4902370736941 2468 5722345 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0245358595445806 0.488841395042371 no 1725 0.490212590268679 2463 23847180 SGTC_917 harmaline 728.087 nM -0.02506023172344 0.488624474173297 no 1726 0.490003460349644 2484 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_884 0851-0618 334 µM -0.0264795334583326 0.48803735832148 no 1727 0.489437428904668 2454 9642473 SGTC_1707 st032323 6.317 µM -0.026728537437392 0.487934356657328 no 1728 0.489338125838007 2460 3132057 YMR211W DML1 SGTC_2110 5483698 200 µM -0.0269269634790483 0.487852277370123 no 1729 0.489258993782498 2468 2848765 YHR062C RPP1 SGTC_1489 4065-0444 182 µM -0.0269419936285431 0.487846060142808 no 1730 0.489252999794996 2450 2877968 SGTC_1173 0443-0020 122 µM -0.0272293549229272 0.487727193598946 no 1731 0.489138401269693 2466 5331295 SGTC_2744 captopril 92.04 µM -0.0282078944218519 0.487322430527172 no 1732 0.488748170446384 2467 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_383 2324-0395 7.37 µM -0.0296758342188673 0.486715256537957 no 1733 0.488162792465675 2497 3146421 SGTC_387 norethindrone acetate 66.7 µM -0.0321048411385631 0.485710631176545 no 1734 0.487194221365822 2493 541197 SGTC_1414 3917-0015 5.4 µM -0.0322190113287216 0.485663413126856 no 1735 0.487148697600573 2468 6618702 SGTC_1665 st014639 11.4 µM -0.0324154115498038 0.485582187181208 no 1736 0.48707038615363 2467 981133 YIL048W NEO1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0327496714452963 0.485443947491514 no 1737 0.486937106514375 2503 521171 SGTC_1877 wortmannin 25 µM -0.0332063581980171 0.485255078621671 no 1738 0.486755013905683 2462 312145 A covalent inhibitor of PI 3-kinase. SGTC_2322 7413319 38.22 µM -0.0332327988574175 0.485244143836824 no 1739 0.486744471427357 2514 1840400 SGTC_80 0159-0065 512.242 µM -0.0333408933841379 0.485199440438121 no 1740 0.486701371834483 2459 1548079 SGTC_314 1671-0008 2.74 µM -0.0335238062127387 0.485123795726751 no 1741 0.486628440943251 2472 3913060 SGTC_517 1365-0151 113 µM -0.034638569475013 0.484662790281218 no 1742 0.486183972974118 2574 768657 SGTC_553 k007-0256 45.7 µM -0.0352057353652602 0.48442824915053 no 1743 0.485957844453854 2489 6287000 SGTC_2837 9008476 45.46 µM -0.0375647933885194 0.48345276236645 no 1744 0.485017339451883 2534 2992805 SGTC_2145 5634607 200 µM -0.0376917811153369 0.483400254821372 no 1745 0.484966714530896 2466 308662 SGTC_1431 4049-0260 9.09 µM -0.0393022258528707 0.482734385047203 no 1746 0.484324716007566 2479 3854841 SGTC_2378 9074213 121.43 µM -0.0393509238067572 0.482714250669518 no 1747 0.484305303352206 2478 657714 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0394380591480993 0.482678224299344 no 1748 0.484270568343979 2454 368090 SGTC_1518 st038567 90.8 µM -0.0394405736402122 0.48267718467708 no 1749 0.484269565986628 2467 77966 SGTC_1765 st044815 90.4 µM -0.0398832952564045 0.482494142299005 no 1750 0.484093084480322 2520 645695 SGTC_1175 0741-0056 27.6 µM -0.0402648869476265 0.482336376927131 no 1751 0.483940973610732 2503 765927 SGTC_1633 st005664 67.9 µM -0.0410539964884879 0.482010136067329 no 1752 0.483626424571352 2483 2063822 SGTC_2566 crystal violet carbinol 226 nM -0.0415062088926352 0.481823183708654 no 1753 0.483446171570377 2578 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2294 7971431 200 µM -0.0415782555941505 0.481793398735469 no 1754 0.483417453885553 2524 5741572 SGTC_29 0299-0004 12.984 µM -0.0416040503406298 0.481782734901641 no 1755 0.483407172167199 2489 16871 A napthoquinone isolated from Swertia calycina. SGTC_1750 st081859 2.357 µM -0.0417507104427195 0.481722104239382 no 1756 0.483348714044731 2485 5291695 SGTC_71 0417-1750 47.813 µM -0.0418144745123749 0.48169574370649 no 1757 0.483323298056491 2474 6811472 SGTC_2903 5923464 63.88 µM -0.0423471868947206 0.481475519648528 no 1758 0.483110964649247 2488 2876576 SGTC_1626 st003712 1.76 µM -0.0424334694899086 0.481439850830905 no 1759 0.483076573787017 2526 24207035 SGTC_1699 st031318 29.054 µM -0.042493221999925 0.481415149512337 no 1760 0.483052757466126 2539 5340658 SGTC_2663 amphotericin b 100 µM -0.0425098961955939 0.481408256515568 no 1761 0.483046111429836 2486 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1243 0416-0003 5.65 µM -0.0427550747468716 0.481306902046873 no 1762 0.482948388187497 2517 2141977 SGTC_1205 4161-2785 76 µM -0.0428700635434868 0.481259367193718 no 1763 0.482902556317019 2594 3498106 SGTC_629 3448-6466 76.7 µM -0.0431905941828574 0.481126865460168 no 1764 0.482774801424191 2487 573744 SGTC_236 1509-0011 5.31 µM -0.0433894910679104 0.48104464603054 no 1765 0.482695527363143 2491 3107280 SGTC_3240 9133527 49.47 µM -0.0441214204380152 0.48074209011575 no 1766 0.482403809184397 2475 17617455 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0442147103447023 0.480703527880819 no 1767 0.482366628180677 2549 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_371 0195-0006 7.36 µM -0.0443911439240194 0.480630597943457 no 1768 0.482296310408249 2462 3928593 SGTC_1715 st032160 10.2275 µM -0.045522590212182 0.4801629229691 no 1769 0.481845384587827 2513 5289825 SGTC_475 α-linolenic acid 10 µM -0.0477835325222307 0.47922846158551 no 1770 0.480944380353744 2568 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_130 0136-0219 337.655 µM -0.0489047228814145 0.478765108725716 no 1771 0.480497612526387 2474 234244 SGTC_382 3229-0966 23.2 µM -0.0490743481206433 0.478695010410877 no 1772 0.480430023001969 2527 5722370 SGTC_3348 9149464 3.537 µM -0.0496866340380606 0.478441986282307 no 1773 0.48018605389817 2487 1951442 SGTC_3091 9116372 49.47 µM -0.0500672129643276 0.478284718294578 no 1774 0.480034413610063 2631 17169793 SGTC_2187 6125751 200 µM -0.0506540650001411 0.478042217969205 no 1775 0.479800590222801 2525 874498 SGTC_1054 3429-0080 167 µM -0.050844855940909 0.477963380651941 no 1776 0.479724573603679 2514 1162877 SGTC_2929 9013348 24.6 µM -0.0512380064182215 0.477800928444709 no 1777 0.479567933431335 2551 2995952 SGTC_2926 9010726 65.15 µM -0.0531841506899285 0.476996824445837 no 1778 0.478792591829642 2560 2994293 SGTC_1964 st076914 61 µM -0.0543401922128786 0.476519217648655 no 1779 0.478332064043095 2487 24208661 SGTC_1555 citronellol 128 µM -0.0544929043227138 0.47645612870099 no 1780 0.478271230860936 2503 8842 A terpine precursor. SGTC_995 3931-2021 34.6 µM -0.0551404491222245 0.476188619360594 no 1781 0.478013285703315 2559 730143 SGTC_2108 5365811 200 µM -0.0558582840567119 0.475892084780748 no 1782 0.477727351707046 2559 780283 SGTC_2514 salinomycin 42.74 µM -0.0564410881435701 0.47565134068664 no 1783 0.477495212749847 2555 23682228 A polyether potassium ionophore. SGTC_1784 st039334 36.3 µM -0.0578247985630081 0.475079794818774 no 1784 0.476944092414126 2646 3496984 SGTC_2847 9005661 71.43 µM -0.0582111953181385 0.474920201552605 no 1785 0.47679020163548 2499 2991449 SGTC_2096 5468907 200 µM -0.0583858747435887 0.474848055112678 no 1786 0.476720632949961 2558 759785 SGTC_1391 3442-0225 151 µM -0.0592320971422189 0.474498558391435 no 1787 0.476383622345788 2522 5227075 SGTC_2808 7946468 45.46 µM -0.0598518759018222 0.474242597166282 no 1788 0.476136804301643 2559 2970879 SGTC_2891 9063876 19.48 µM -0.061611790072239 0.473515831946457 no 1789 0.47543599383101 2512 6472478 SGTC_1347 1493-0251 600 nM -0.0616574014931705 0.473496997647027 no 1790 0.475417832036241 2548 3986378 SGTC_3262 9137218 49.47 µM -0.0616634977828176 0.47349448031392 no 1791 0.47541540458753 2485 17650664 SGTC_1714 st033236 13.627 µM -0.0628039235483226 0.473023584486239 no 1792 0.474961320749789 2575 2916566 SGTC_1031 k035-0009 16 µM -0.0635424098397206 0.472718674479786 no 1793 0.47466729464397 2531 5180959 SGTC_412 gemfibrozil 100 µM -0.0635632197580509 0.472710082604744 no 1794 0.474659009436414 2509 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1826 st055655 41.6 µM -0.0638657015457191 0.472585197162867 no 1795 0.474538581351829 2555 676168 SGTC_1012 4112-3522 18 µM -0.0647589499767743 0.47221641809088 no 1796 0.474182962990702 2519 3112398 SGTC_1678 st019265 80.2 µM -0.0660032229395748 0.471702757731624 no 1797 0.473687629758703 2534 5367020 SGTC_2601 securinine 100 µM -0.0684055277882391 0.470711172925554 no 1798 0.472731410800611 2559 442872 A GABA receptor antagonist. SGTC_2315 7733312 200 µM -0.0689309527609747 0.470494320430986 no 1799 0.47252229018394 2556 726316 SGTC_222 nsc-310342 10.666 µM -0.0693508120834937 0.470321043096871 no 1800 0.472355190434279 2519 432556 SGTC_1981 st071826 47 µM -0.069923183440059 0.470084832599388 no 1801 0.472127400285969 2595 11838600 SGTC_2350 9023895 38.85 µM -0.0711528394928347 0.469577404637972 no 1802 0.471638057432347 2606 2997209 SGTC_3075 9116269 49.47 µM -0.0721147360559932 0.469180504290282 no 1803 0.471255299541374 2606 17015205 YNL244C SUI1 SGTC_41 0478-0632 82.643 µM -0.0723213617768484 0.469095249811814 no 1804 0.471173082484377 2513 3750424 SGTC_1155 4088-0394 48.2 µM -0.0733778364979918 0.46865936696007 no 1805 0.470752726977464 2524 2326248 SGTC_663 1486-0733 13.9 µM -0.0736600123781206 0.468542952499707 no 1806 0.470640458905367 2558 722445 YPR165W RHO1 SGTC_1763 st044482 94.5 µM -0.0737544025277235 0.468504011506383 no 1807 0.470602904833514 2636 88505 SGTC_2938 9059746 27.26 µM -0.0739137219589184 0.468438284389803 no 1808 0.470539518586143 2608 6471769 SGTC_2028 5153890 36.43 µM -0.0740796679111901 0.468369824421447 no 1809 0.470473496728947 2537 2830968 YPR165W RHO1 SGTC_162 k030-0015 37.8 µM -0.074511940640291 0.468191497397893 no 1810 0.470301520161425 2583 1809920 YMR134W ERG29 SGTC_2773 thioridazine 9.09 µM -0.0748387386657211 0.468056686467699 no 1811 0.470171509614153 2525 5452 An antipsychotic. SGTC_1649 st011737 51.3 µM -0.0757250550954148 0.467691081132165 no 1812 0.469818921068794 2583 1761035 SGTC_911 3456-4043 236 µM -0.0761465263617189 0.46751723386798 no 1813 0.469651262439728 2597 914281 SGTC_443 clozapine 122 µM -0.0765613798841419 0.467346122322072 no 1814 0.469486241562179 2527 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1465 k213-0056 144 µM -0.0775479742875347 0.466939213364848 no 1815 0.469093814091915 2523 24048857 YMR208W ERG12 SGTC_76 0433-0009 400.328 µM -0.0779471647984105 0.46677458184924 no 1816 0.46893504071363 2691 2841569 SGTC_1281 0884-0031 11.8 µM -0.0781929149840812 0.466673234004785 no 1817 0.468837298893554 2549 1548255 SGTC_2472 5377652 49.4 µM -0.0784764690636873 0.466556298447896 no 1818 0.46872452372663 2582 1610903 SGTC_2213 7173844 200 µM -0.0806315292037459 0.465667663019331 no 1819 0.46786749557724 2551 892728 SGTC_2055 5235184 200 µM -0.0811220624723326 0.465465416204786 no 1820 0.467672440097155 2626 2836034 SGTC_1300 1094-0077 113 µM -0.0823655825454953 0.46495275309682 no 1821 0.467178002088212 2566 5532636 SGTC_113 0099-0221 2.5 µM -0.0841127237728573 0.464232561744424 no 1822 0.466483404193771 2544 89219 SGTC_658 3253-0951 102 µM -0.0852100177089896 0.463780304542924 no 1823 0.466047213284442 2593 1184878 SGTC_1898 st060199 18.6 µM -0.086105234669096 0.463411369388349 no 1824 0.465691381208915 2565 688866 SGTC_738 1315-0003 72.4 µM -0.0866090222528511 0.463203763198751 no 1825 0.465491147065692 2616 6251474 SGTC_1404 3909-7820 48.3 µM -0.086758737095908 0.463142069029825 no 1826 0.465431643463194 2570 23741373 SGTC_2022 5136654 200 µM -0.0869026098547098 0.463082783089604 no 1827 0.465374462503383 2662 1713771 SGTC_805 3852-0218 479 µM -0.0870127187036905 0.463037410866176 no 1828 0.465330701194799 2576 6615355 SGTC_2057 5236571 38.335 µM -0.0873149458749003 0.462912875494467 no 1829 0.465210587151376 2589 54684039 YBR257W POP4 SGTC_1857 st056007 79.3 µM -0.0884260837853655 0.462455052657796 no 1830 0.464769015315343 2616 619834 SGTC_914 3820-6779 408 µM -0.0890498611990838 0.462198059024531 no 1831 0.464521141989501 2570 2893481 SGTC_1360 1598-0022 39.8 µM -0.0904534958208072 0.461619825417762 no 1832 0.463963423679992 2652 761525 SGTC_2994 9053520 71.4286 µM -0.0906099283367738 0.461555387339727 no 1833 0.463901271357932 2627 4647384 SGTC_727 3032-0951 202 µM -0.0910982425448947 0.461354246214687 no 1834 0.463707264541968 2618 3652836 SGTC_2329 6138490 200 µM -0.0912965141967744 0.461272579111857 no 1835 0.463628493845629 2825 720019 SGTC_172 1112-0046 2.638 µM -0.0917335472737863 0.461092573142946 no 1836 0.463454871442911 2613 2802135 YIL048W NEO1 SGTC_686 1319-0111 510 µM -0.0918897425433601 0.461028241086369 no 1837 0.463392820622754 2620 4562600 SGTC_2341 7987486 176.74 µM -0.0932566210871628 0.46046530929919 no 1838 0.462849846601021 2596 1258686 SGTC_2044 5102272 200 µM -0.0950643194908946 0.459720953235525 no 1839 0.46213186930335 2646 592666 SGTC_2840 9008771 71.43 µM -0.0951342616762074 0.459692155958051 no 1840 0.46210409229875 2716 2992978 SGTC_846 0335-0850 148 µM -0.0969702994590926 0.458936280694118 no 1841 0.46137499043196 2580 6819598 SGTC_2247 cerulenin 830 nM -0.0969960406349243 0.4589256844021 no 1842 0.461364769370082 2786 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_735 3076-0345 636 µM -0.0970376000808649 0.458908576619511 no 1843 0.46134826739345 2648 2888990 SGTC_190 3970-0790 3.722 µM -0.0971265981644686 0.458871941164189 no 1844 0.461312929218023 2554 2832352 SGTC_55 0767-0285 6.563 µM -0.0982469850048094 0.458410771527317 no 1845 0.46086808713117 2586 3116166 SGTC_1248 0469-0687 58.6 µM -0.0983184766405178 0.458381346288381 no 1846 0.460839703512291 2655 4017482 SGTC_449 xestospongin c 11.1929 µM -0.0988737624222012 0.458152804017496 no 1847 0.46061925067992 2664 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_323 4013-0906 34.3 µM -0.0990543234843399 0.458078492404467 no 1848 0.460547569119369 2692 2910086 SGTC_2420 aureobasidin a 50 nM -0.0994684578649039 0.457908057021715 no 1849 0.460383165325442 2855 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1172 0370-0043 85 µM -0.0997262505103771 0.457801967374245 no 1850 0.460280829766261 2715 376585 SGTC_2069 5228469 200 µM -0.100578572127362 0.457451232108623 no 1851 0.459942503699708 2682 2835210 SGTC_529 4076-0302 30.3 µM -0.101905836610347 0.456905121187931 no 1852 0.459415708569565 2591 5816522 SGTC_1358 1509-0022 2.48 µM -0.10230812403903 0.456739613639222 no 1853 0.459256053547999 2621 3258434 SGTC_445 e6 berbamine 66 µM -0.10247041118684 0.456672848206868 no 1854 0.459191648825047 2669 6610268 A calcium/calmodulin antagonist. SGTC_2983 9022671 12.99 µM -0.103130428873838 0.456401327520088 no 1855 0.458929727514088 2802 6405161 SGTC_1084 voriconazole 435 nM -0.103335934654561 0.456316789889087 no 1856 0.458848178268042 2609 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2551 apiole 73.87 µM -0.103429642937926 0.456278242353288 no 1857 0.458810993320096 2572 10659 A possible DNA adduct former. SGTC_1055 3448-0672 86 µM -0.103809762943538 0.456121881643257 no 1858 0.458660159312226 2710 748378 SGTC_1529 apigenin 74 µM -0.104351919054493 0.455898879849309 no 1859 0.45844503866266 2682 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2718 lomofungin 53.02 µM -0.105837379629303 0.455287945719646 no 1860 0.4578556893386 2681 5351222 A RNA synthesis inhibitor. SGTC_458 nppb 133 µM -0.106492816909066 0.455018413695851 no 1861 0.457595677139214 2648 4549 A chloride channel blocker. SGTC_3330 9141424 71.43 µM -0.108200885519459 0.454316111227852 no 1862 0.456918171269187 2713 27261020 SGTC_1224 0823-0416 294 µM -0.108872114496596 0.454040162584628 no 1863 0.456651962276075 2706 3598164 SGTC_803 4488-1585 147 µM -0.109112322340876 0.453941416228727 no 1864 0.45655670071536 2671 747204 SGTC_1993 st073995 70.8 µM -0.10911999009633 0.453938264159921 no 1865 0.456553659880107 2639 3098394 SGTC_1496 4469-0713 57.4 µM -0.109293987083313 0.45386673807964 no 1866 0.456484657819691 2586 746691 SGTC_3354 9151612 71.43 µM -0.109670924476741 0.453711793092922 no 1867 0.456335180097637 2683 27261949 SGTC_880 0833-0487 87.2 µM -0.110598259563185 0.453330630057375 no 1868 0.455967463843758 2606 76075 SGTC_2569 tetrandrine 100 µM -0.11092496552632 0.45319635415377 no 1869 0.455837924070153 2670 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1611 st001856 99.4 µM -0.111817680214389 0.452829476424802 no 1870 0.455483984327622 2611 647478 SGTC_3100 9120536 49.47 µM -0.111870752098517 0.452807666810412 no 1871 0.45546294372138 2566 16421196 SGTC_264 promethazine 12.5 mM -0.111980428100661 0.452762596479694 no 1872 0.455419462533507 2598 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1782 st039423 80.636 µM -0.112184636270049 0.452678680657951 no 1873 0.45533850537319 2648 2068169 SGTC_2886 9058944 51.95 µM -0.112207633178486 0.45266923060779 no 1874 0.455329388496552 2577 4949929 SGTC_2964 9083345 53.42 µM -0.112404723907102 0.452588241809654 no 1875 0.455251254965435 2644 17741579 SGTC_1635 st007035 42.4 µM -0.112607369278141 0.45250497254676 no 1876 0.455170921188203 2582 3716403 SGTC_3257 9139206 32.98 µM -0.112782455260757 0.452433029428557 no 1877 0.455101514129247 2702 4910041 SGTC_3323 9138564 53.9225 µM -0.112817197821937 0.452418753838644 no 1878 0.455087741750468 2642 43912313 YNL103W MET4 SGTC_961 1252-1571 372 µM -0.112884450808496 0.452391120009955 no 1879 0.45506108199241 2676 6813498 SGTC_724 3910-0327 137 µM -0.113855031024694 0.451992340456846 no 1880 0.454676356861865 2647 2885483 SGTC_2572 astragaloside iv 100 µM -0.117025298519131 0.450690121147175 no 1881 0.453420002950131 2791 45006101 An anti-inflammatory agent. SGTC_1907 st060210 83.7 µM -0.119124573555179 0.449828113911426 no 1882 0.452588331240111 2731 688793 SGTC_1643 st009866 20.2 µM -0.119778397301032 0.449559688041512 no 1883 0.452329347589686 2634 3156273 YOR207C RET1 SGTC_3095 9117207 49.47 µM -0.120184840441875 0.449392835348282 no 1884 0.452168363150409 2678 17015229 SGTC_1385 3091-4834 14.1 µM -0.12044121110705 0.449287594880567 no 1885 0.452066823622508 2717 4072814 SGTC_65 0798-0905 34.986 µM -0.12045873706539 0.449280400583688 no 1886 0.452059882312739 2920 3602145 SGTC_296 1222-0039 74.9 µM -0.120970147208814 0.44907047725269 no 1887 0.451857340293981 2653 5984176 SGTC_3141 9094609 49.47 µM -0.121440577962255 0.44887738770379 no 1888 0.451671039067787 2619 25236309 YDL196W YDL196W SGTC_1613 st002381 52.1 µM -0.121587880213757 0.448816929591487 no 1889 0.45161270622823 2634 551167 SGTC_360 0957-0399 1.01 µM -0.122124911201694 0.448596522942459 no 1890 0.451400046628744 2733 6752301 YPR165W RHO1 SGTC_395 anisomycin 6.25 µM -0.122859809011449 0.448294934107571 no 1891 0.451109056102527 2666 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2600 tangeritin 87.95 µM -0.123091603658549 0.4481998159466 no 1892 0.451017280013985 2641 68077 A bioactive flavone. SGTC_616 4092-0450 108 µM -0.12326661479684 0.448128001171984 no 1893 0.450947988354975 2676 787165 SGTC_928 2764-0428 58.7 µM -0.12344679129814 0.448054068597566 no 1894 0.450876653150241 2750 662578 SGTC_1494 4358-1428 177 µM -0.125971499193676 0.447018285631173 no 1895 0.449877242585474 2718 1564571 SGTC_415 dibenzyl ketone 100 µM -0.126735947242372 0.446704735227384 no 1896 0.449574696722356 2724 7593 SGTC_787 4152-0075 138 µM -0.126982051559893 0.446603798746218 no 1897 0.449477302161818 2674 9566539 SGTC_922 1866-0035 480 µM -0.127145865574445 0.446536614478511 no 1898 0.449412475266555 2636 3156169 SGTC_260 nsc-65238 3.989 µM -0.127223168025606 0.446504911322323 no 1899 0.449381884470516 2719 3246252 SGTC_2100 5377183 190 µM -0.129833794079558 0.445434447632193 no 1900 0.448348962694433 2713 2844202 SGTC_1026 k007-1105 30.6 µM -0.13020619646603 0.445281779619924 no 1901 0.448201646123459 2633 7066794 SGTC_1393 3470-5649 58.2 µM -0.130448120987753 0.445182605934389 no 1902 0.448105948385245 2730 4108395 SGTC_146 3448-8650 53.125 µM -0.131548418886875 0.444731597067442 no 1903 0.447670743298677 2669 2891488 YIL048W NEO1 SGTC_1931 st074438 57.1 µM -0.131765220265345 0.444642739239826 no 1904 0.447584998422296 2593 2787313 SGTC_1997 st073024 93.8 µM -0.132038767186917 0.444530627754715 no 1905 0.44747681419712 2621 686268 SGTC_2748 diazoxide 86.69 µM -0.132145604068026 0.444486842535571 no 1906 0.447434562670371 2726 3019 A potassium channel activatior. SGTC_1854 st056233 32.9 µM -0.132472537332317 0.444352858890343 no 1907 0.447305271799032 2627 5393174 SGTC_1184 1269-1718 139 µM -0.132738199114546 0.444243990178875 no 1908 0.447200215816355 2765 5403821 SGTC_37 0566-0070 1.56 µM -0.133307990840173 0.444010502626989 no 1909 0.446974904115188 2754 1626686 SGTC_583 1488-1091 88.9 µM -0.134098959935317 0.443686413900573 no 1910 0.446662161033588 2621 4303273 SGTC_358 0075-0058 9.45 µM -0.134726318326727 0.44342938918363 no 1911 0.446414131941426 2578 1069125 SGTC_19 0279-0214 38.434 µM -0.137151072775482 0.442436207506708 no 1912 0.445455691808055 2647 3566274 YBR002C RER2 SGTC_502 l-744,832 89.3 µM -0.137448282847086 0.442314494742789 no 1913 0.445338234484598 2739 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2240 6690706 185.951 µM -0.139625253083505 0.441423153784952 no 1914 0.444478043495973 2629 805876 SGTC_3271 9137798 49.47 µM -0.143320780188402 0.439910734734431 no 1915 0.443018422515339 2712 6498326 SGTC_2488 5268135 45.7 µM -0.143671873470762 0.439767092717062 no 1916 0.44287979122605 2783 1270356 YLR208W SEC13 SGTC_1458 k015-0034 6.33 µM -0.144005590838351 0.439630567018744 no 1917 0.442748027402864 2703 3598957 SGTC_2912 7964298 10.93 µM -0.144457247459588 0.439445803128551 no 1918 0.442569706935334 2742 2975850 SGTC_1588 farnesol 29.9 µM -0.145075842307246 0.439192769486721 no 1919 0.442325495764289 2669 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1036 k216-0215 33.5 µM -0.145954033082676 0.438833591908888 no 1920 0.441978838011192 2653 622330 SGTC_1698 5-fluorocytosine 1.055 µM -0.146226356137878 0.438722222755253 no 1921 0.441871349995892 2682 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1154 4088-0362 150 µM -0.146643154612217 0.438551778376281 no 1922 0.441706844707011 2659 6618304 SGTC_2549 cedrol 20.94 µM -0.146815314526914 0.438481379115844 no 1923 0.44163889821502 2776 6708665 A sedative which affects the nervous system. SGTC_63 0099-0242 26.702 µM -0.146860956424386 0.438462715656053 no 1924 0.441620884978559 2667 3898502 YLR359W ADE13 SGTC_279 1273-0055 2.93 µM -0.147701661306467 0.438118966960408 no 1925 0.441289110242991 2741 2847562 SGTC_1987 st072290 61.9 µM -0.149086908051597 0.437552667113689 no 1926 0.440742528148589 2715 54697379 SGTC_2282 7944268 200 µM -0.149746606725608 0.43728302195339 no 1927 0.44048226793771 2809 2970414 SGTC_2383 9036125 200 µM -0.1502026024779 0.437096655320045 no 1928 0.440302386354807 2670 79580 SGTC_399 oxolinic acid 75 µM -0.151504413821501 0.43656467862717 no 1929 0.439788914651553 2665 4628 A DNA gyrase inhibitor. SGTC_2375 9072683 200 µM -0.153058239407422 0.435929868204445 no 1930 0.439176173944473 2666 16798029 SGTC_647 0140-0236 81 µM -0.153769078539545 0.435639512091868 no 1931 0.438895907785548 2710 990837 SGTC_1497 4476-2978 41.3 µM -0.154235496516765 0.435449013408002 no 1932 0.438712027433664 2757 1528379 SGTC_1272 0839-0021 27 µM -0.154427833463811 0.435370461757517 no 1933 0.438636204477365 2757 5027250 SGTC_666 0272-0154 136 µM -0.154826644503826 0.435207592884404 no 1934 0.438478992606807 2723 6870312 SGTC_1009 4106-0057 9.87 µM -0.155247056389211 0.435035914427979 no 1935 0.438313276163101 2673 2928005 SGTC_2036 5160441 105 µM -0.155324980840133 0.435004094717967 no 1936 0.438282561370809 2719 134534 YIL048W NEO1 SGTC_2935 9038016 29.96 µM -0.15561295600199 0.434886506447252 no 1937 0.438169055972701 2728 6463195 SGTC_14 0354-0009 295 µM -0.155817558442893 0.434802965076827 no 1938 0.438088415019234 2642 1713507 SGTC_2246 7293507 91.5585 µM -0.157459404049832 0.43413268761474 no 1939 0.437441399805513 2878 887656 SGTC_2004 4023728 41.89 µM -0.158107299783345 0.433868238541838 no 1940 0.437186124284863 2760 360084 YDR527W RBA50 SGTC_164 4100-3994 89.624 µM -0.158701893600468 0.433625571546318 no 1941 0.436951873105337 2683 4615967 SGTC_3209 9113616 49.47 µM -0.159483894652446 0.433306457581415 no 1942 0.436643823060422 2775 16649353 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.160488460086681 0.43289658480067 no 1943 0.436248155659935 2676 165521 SGTC_1263 0774-1208 64.8 µM -0.161407956830564 0.432521484158347 no 1944 0.435886050099608 2786 906585 SGTC_820 1582-0060 59.9 µM -0.16184275341159 0.432344133855228 no 1945 0.435714842239704 2722 3848840 SGTC_3042 9091578 49.47 µM -0.164434357915126 0.431287321542172 no 1946 0.434694608983652 2672 25236497 SGTC_1634 st006576 41 µM -0.165473956700692 0.430863528568795 no 1947 0.434285473392188 2814 3915356 SGTC_89 0302-0250 142.109 µM -0.166599865249551 0.430404641174309 no 1948 0.43384244986597 2662 4203518 YLR208W SEC13 SGTC_2525 harmine 47.85 µM -0.167226889457205 0.430149125144797 no 1949 0.433595763794716 2791 5280953 A monoamine oxidase inhibitor SGTC_2596 sinensetin 100 µM -0.167701292994244 0.429955822360966 no 1950 0.433409139467615 2770 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_913 3487-1245 167 µM -0.168353471242626 0.429690110037198 no 1951 0.433152605069674 2675 4016153 SGTC_3143 9086658 49.47 µM -0.168888544732321 0.429472132645012 no 1952 0.432942154872019 2796 25236626 SGTC_825 1988-2224 89.6 µM -0.169400930409531 0.429263417930041 no 1953 0.432740645860551 2708 1180859 SGTC_2963 9082507 9 µM -0.170013094860622 0.429014085349328 no 1954 0.432499919182503 2850 16459611 SGTC_1885 st057546 99.9 µM -0.170334225685618 0.428883301132871 no 1955 0.43237364816622 2860 702008 SGTC_2298 7976326 193.81 µM -0.172921872565501 0.427829738368394 no 1956 0.431356419409589 2753 2235818 SGTC_3090 9117696 49.47 µM -0.173809129557656 0.427468608918725 no 1957 0.431007734628262 2814 7923821 SGTC_2324 6149169 200 µM -0.173835989681245 0.427457677314557 no 1958 0.430997179655318 2791 2888231 SGTC_1776 st049249 45.9 µM -0.174654937307793 0.427124406617154 no 1959 0.430675389116702 2753 1822314 SGTC_2674 ligustilide 100 µM -0.174693560512248 0.427108690188318 no 1960 0.43066021396752 2800 5319022 A signalling regulator. SGTC_1330 1469-0054 61.8 µM -0.175358906543688 0.426837967927893 no 1961 0.430398814017222 2878 7102664 SGTC_2016 5121758 140 µM -0.175784499361142 0.426664816776171 no 1962 0.430231623863508 2682 2795203 SGTC_1911 st060208 74.3 µM -0.176724633246712 0.426282376280118 no 1963 0.429862345441165 2824 688783 SGTC_2890 9046729 58.44 µM -0.177061093152968 0.426145523349194 no 1964 0.429730201087639 2767 903329 SGTC_206 4546-0025 72.014 µM -0.178086393641101 0.425728543795597 no 1965 0.42932756376418 2747 6620745 YIL048W NEO1 SGTC_43 0570-0105 72.5 µM -0.179029443037808 0.42534508825104 no 1966 0.428957291483181 2720 1114046 YDL195W SEC31 SGTC_2624 nerol 100 µM -0.18139122689922 0.424385068346715 no 1967 0.428030252288871 2694 637566 A natural product oil. SGTC_177 1327-0068 8.361 µM -0.182488985464722 0.423939002822908 no 1968 0.427599498776559 2709 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_23 0213-0011 39.996 µM -0.182805279976766 0.423810497101564 no 1969 0.427475402801964 2857 627608 SGTC_1770 st043884 66.3 µM -0.182966647288337 0.423744939100768 no 1970 0.427412094211347 2727 670149 SGTC_2853 9015042 58.44 µM -0.184843559452466 0.422982569598673 no 1971 0.426675870505239 2710 6457456 SGTC_2399 5884133 200 µM -0.185931591201647 0.422540761607651 no 1972 0.426249203973996 2767 722445 SGTC_3069 9117009 49.47 µM -0.186167953189333 0.422444796926228 no 1973 0.426156527126719 2768 41904981 SGTC_1068 loratadine 26.9 µM -0.186501374816013 0.422309433155493 no 1974 0.426025800412377 2780 3957 A H1 histamine antagonist. SGTC_1463 k081-0032 34.1 µM -0.186636112985994 0.422254734246886 no 1975 0.425972975075983 2803 977755 SGTC_907 3448-6986 75.5 µM -0.187055176998532 0.422084618739502 no 1976 0.425808685677925 2877 590582 SGTC_3025 9087895 49.47 µM -0.187674833684952 0.421833100971608 no 1977 0.425565779754535 2846 17173641 SGTC_882 0843-0131 351 µM -0.187826882708679 0.421771389356499 no 1978 0.425506180726437 2725 5425421 SGTC_2927 9011802 47.9 µM -0.189040026099995 0.42127908394621 no 1979 0.425030723017245 2864 43912568 SGTC_1421 4029-0249 71.4 µM -0.189617109437748 0.421044941043615 no 1980 0.424804589527145 2891 2894095 SGTC_617 3770-0098 35 µM -0.190315691055225 0.420761539404644 no 1981 0.424530879336232 2754 5962639 SGTC_1976 st070609 63.5 µM -0.190447534477425 0.420708057568881 no 1982 0.424479226045281 2684 682556 SGTC_1278 0874-0585 172 µM -0.190943040950146 0.420507070147475 no 1983 0.424285109344766 2813 766306 SGTC_1162 k048-0130 20.1 µM -0.191031624823369 0.420471140923467 no 1984 0.424250408181529 2747 6797406 SGTC_2413 inermin 26.06 µM -0.192493638611483 0.419878250576939 no 1985 0.423677775195302 3053 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_8 0354-0001 70 µM -0.193508894811167 0.419466640677551 no 1986 0.423280220328572 2747 4993152 SGTC_1558 st069300 45.6 µM -0.194230614816367 0.419174091140161 no 1987 0.42299765607691 2796 24208000 SGTC_2361 9034121 116 µM -0.194775210064318 0.418953368773311 no 1988 0.422784465046988 2790 6496917 SGTC_1230 0170-0365 3.77 µM -0.195001227510422 0.418861772254473 no 1989 0.422695993327487 2846 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1098 clofazimine 15.1 µM -0.19831172205674 0.417520657663793 no 1990 0.421400590473066 2860 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3302 9125395 16.351 µM -0.198342971702323 0.417508002662385 no 1991 0.421388366455942 2813 17599668 SGTC_2078 5212016 200 µM -0.199154813639179 0.417179265366099 no 1992 0.421070822408307 2721 1899708 SGTC_784 4579-0127 173 µM -0.199972351668777 0.416848280063688 no 1993 0.420751102268714 2965 1948547 SGTC_471 1-acyl-paf 4 µM -0.2000958076789 0.416798303254165 no 1994 0.420702826027034 2752 16759367 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.200270220660276 0.416727700604738 no 1995 0.420634625602532 2829 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2117 5521686 200 µM -0.201093020644647 0.416394666136369 no 1996 0.420312919622772 2743 803312 SGTC_3258 9138477 49.47 µM -0.202760770641601 0.415719816137459 no 1997 0.419661010734792 2785 4970355 SGTC_1182 1222-0449 220 µM -0.203644310179691 0.415362395093942 no 1998 0.419315732060753 2830 658318 SGTC_1984 st072354 53.1 µM -0.203768376909312 0.41531221158753 no 1999 0.419267252955192 2744 5762938 SGTC_910 3454-3003 490 µM -0.206236041263584 0.414314358944773 no 2000 0.418303268038824 2835 820824 SGTC_1197 1601-0112 267 µM -0.209056470758867 0.41317453550333 no 2001 0.417202077566171 2770 7350313 SGTC_967 1306-0166 352 µM -0.209138091547855 0.413141560843641 no 2002 0.417170219690458 2898 4437607 SGTC_227 fluconazole 33.516 µM -0.209428201637269 0.413024361822859 no 2003 0.417056989569641 2802 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2458 5808907 16.39 µM -0.211227185587981 0.412297779587484 no 2004 0.416354999132767 2873 2731747 SGTC_175 3793-3120 23.7 µM -0.211509177119063 0.412183914679155 no 2005 0.416244985944884 2800 5322297 SGTC_974 1326-0144 138 µM -0.211916486595133 0.412019460890362 no 2006 0.416086094127226 2793 5411856 SGTC_2061 5245884 80.95 µM -0.212335409904953 0.41185033405931 no 2007 0.415922686048507 2771 573863 SGTC_251 melphalan 456.522 µM -0.214388239597626 0.411021807277069 no 2008 0.415122155956454 2854 460612 A DNA alkylator. SGTC_1348 1493-0373 93.8 µM -0.215071242963882 0.410746233331642 no 2009 0.414855887028461 2863 3010129 SGTC_2079 5212404 121 µM -0.215868921980211 0.410424446542313 no 2010 0.414544961307392 2896 758462 SGTC_1841 st054148 70 µM -0.215887807504047 0.410416828779013 no 2011 0.414537600604523 2868 675442 SGTC_1469 k284-2957 126 µM -0.215902748662984 0.410410802059238 no 2012 0.414531777253748 2823 23884841 SGTC_1817 st052116 64.4 µM -0.21619739744841 0.410291955786266 no 2013 0.414416941057157 2940 4361398 SGTC_736 0958-0254 92.6 µM -0.216462799807241 0.410184913080138 no 2014 0.414313509602662 2900 6812352 SGTC_1563 conessine 56.1 µM -0.216796160229311 0.410050470849534 no 2015 0.41418360224672 2916 441082 An anti-amoebic, histamine inhibitor. SGTC_2491 paeonol 100 µM -0.217531034787908 0.409754137773551 no 2016 0.413897261865472 2752 11092 Increases levels of cortical cytochrome oxidase. SGTC_943 3253-1379 105 µM -0.218084841567099 0.409530853073217 no 2017 0.413681503919775 2952 668464 SGTC_645 0845-0943 5.41 µM -0.218567899094424 0.409336117124753 no 2018 0.413493330495663 2838 1885106 SGTC_1688 st021091 57.6 µM -0.218958858654496 0.409178525191005 no 2019 0.413341048066936 2856 3656366 SGTC_1493 4348-0038 111 µM -0.220528644787511 0.408545907949565 no 2020 0.412729733064297 2829 800424 SGTC_3311 9131146 2.8755 µM -0.220822334996875 0.408427578429833 no 2021 0.412615386013444 2849 4900406 YPR165W RHO1 SGTC_1298 1079-1278 263 µM -0.221670841299574 0.408085757169564 no 2022 0.4122850653386 2819 2840950 SGTC_1053 3366-3204 134 µM -0.221731640429927 0.408061266886541 no 2023 0.412261398822367 2848 3632071 YPR165W RHO1 SGTC_1000 4048-0884 8.67 µM -0.222992666585381 0.407553398509457 no 2024 0.411770607016251 2926 13040088 SGTC_749 1000-0129 128 µM -0.223823411839172 0.4072189072056 no 2025 0.411447356033605 2966 708470 SGTC_1377 2944-0135 198 µM -0.223984814344296 0.407153927935167 no 2026 0.411384559729698 2874 1894137 SGTC_400 oxethazaine 37.5 µM -0.224762599611983 0.406840834083917 no 2027 0.411081981412677 2874 4621 A local anesthetic. SGTC_2466 5983409 37.09 µM -0.229375230100186 0.404985270952075 no 2028 0.409288643248942 2840 2879657 SGTC_189 3970-0742 2.116 µM -0.231016449313746 0.404325555978746 no 2029 0.408651011471287 2833 2891807 SGTC_2899 9053889 58.44 µM -0.232044050670202 0.403912633087506 no 2030 0.408251899949092 2886 6470052 SGTC_143 4032-1194 15.74 µM -0.23224141057776 0.40383333984343 no 2031 0.408175257940199 2743 1806963 SGTC_1363 1636-0063 10.4 µM -0.233427593735274 0.403356850674226 no 2032 0.407714694108832 2825 6072185 SGTC_661 1304-0007 33.6 µM -0.234149436684335 0.403066956886134 no 2033 0.407434483777499 2830 3117130 SGTC_3341 9147222 25.867 µM -0.234254725360415 0.403024677159644 no 2034 0.407393615995242 2952 1939759 SGTC_1804 st050076 49.1 µM -0.235171221749256 0.402656696759353 no 2035 0.407037920693332 2937 3895976 SGTC_403 arphamenine a 50 µM -0.235541740146072 0.40250795520909 no 2036 0.406894143012657 2816 5487158 An arginine aminopeptidase inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.235867011988428 0.402377389146248 no 2037 0.406767933357129 2768 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1966 st070145 16.1 µM -0.236146221933053 0.402265321290115 no 2038 0.406659604032382 2779 3748532 SGTC_3309 9129340 25.759 µM -0.237605348284345 0.401679795518313 no 2039 0.40609360098608 2860 17158987 SGTC_1906 st060206 94.7 µM -0.238250788835159 0.401420860106096 no 2040 0.405843293607819 2977 5133468 SGTC_860 0443-0016 25.1 µM -0.238456236622124 0.401338448411618 no 2041 0.405763627265635 2826 5337942 SGTC_174 3553-0389 74.3 µM -0.239220175420433 0.401032046594265 no 2042 0.405467429523637 2977 738071 SGTC_1092 toremifene 6.32 µM -0.239793032718525 0.400802323977333 no 2043 0.4052453542512 2820 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1412 3909-8563 178 µM -0.240458855141813 0.400535364340497 no 2044 0.404987278224613 2924 23767530 SGTC_3160 9100216 49.47 µM -0.241283522847662 0.400204780545538 no 2045 0.404667690277853 2794 17191039 SGTC_843 0310-0051 143 µM -0.244222231207471 0.399027326051749 no 2046 0.40352935512822 2878 2065037 SGTC_2418 pentamidine 31.67 µM -0.244991167770208 0.39871938677945 no 2047 0.40323163505369 2821 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1337 1486-1011 40.3 µM -0.24586841466079 0.398368149005191 no 2048 0.40289204742816 2838 X1337 SGTC_1851 st056236 18.9 µM -0.246062508546678 0.398290447553916 no 2049 0.402816922386226 2972 5393171 SGTC_3022 9087993 49.47 µM -0.246970638504846 0.397926950231065 no 2050 0.402465473699071 2875 17173644 SGTC_2760 etidronate 98.04 µM -0.247695003330175 0.397637072100651 no 2051 0.402185199094837 2870 3305 A chelator and antioxidant. SGTC_1368 1852-0141 284 µM -0.248326645596083 0.397384346035101 no 2052 0.401940842169399 2960 2838987 SGTC_1940 st075990 51.1 µM -0.248347000347126 0.397376202621831 no 2053 0.401932968373832 3087 1084979 SGTC_871 0574-0004 149 µM -0.251122375425692 0.396266266598702 no 2054 0.400859748497296 2854 9551173 SGTC_2715 st079500 56.4 µM -0.251183486881049 0.396241836151196 no 2055 0.400836125471558 2821 28246688 SGTC_2249 haloperidol 116.36 µM -0.251188670115877 0.396239764074853 no 2056 0.400834121875512 2826 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2614 arthonioic acid 13.39 µM -0.252710235756624 0.395631622208892 no 2057 0.400246068791021 2809 6710684 SGTC_3019 9081971 49.47 µM -0.25276334511 0.395610399954321 no 2058 0.400225547219889 3010 16451803 SGTC_571 k831-0106 44.2 µM -0.253214414635523 0.395430167119879 no 2059 0.40005126407286 2911 4783639 SGTC_1972 st070201 17.4 µM -0.253351274189425 0.395375486876496 no 2060 0.399998388545426 2991 2829099 SGTC_393 acivicin 6.25 µM -0.257203380455124 0.393837282549684 no 2061 0.398510887274876 2862 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.257349706664608 0.393778884755279 no 2062 0.398454411922779 2872 641818 YHR062C RPP1 SGTC_1216 1165-0504 9.65 µM -0.257513431272469 0.393713546210189 no 2063 0.398391224090499 2977 6304004 SGTC_2876 9059903 25.97 µM -0.257692129795579 0.393642235351776 no 2064 0.39832226026998 2826 6916095 SGTC_2063 5246145 200 µM -0.258748778419265 0.393220645525898 no 2065 0.397914540530799 2987 711240 SGTC_195 4234-0266 16.654 µM -0.259229104457747 0.393029042692803 no 2066 0.397729238157314 2893 2303354 SGTC_490 phenamil 164 µM -0.260869309608349 0.392374957789901 no 2067 0.397096646468867 2958 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_949 1165-0505 146 µM -0.262251813179283 0.39182387569419 no 2068 0.396563654825629 2887 6244267 SGTC_2136 5328288 199.296 µM -0.2639178168229 0.391160075500909 no 2069 0.395921623202955 2907 262395 SGTC_2442 5158906 48.48 µM -0.264913723838272 0.390763418901911 no 2070 0.395537962922877 3012 1893835 SGTC_1747 st037496 66.6 µM -0.265532055407454 0.390517202763062 no 2071 0.395299809596507 2903 723305 SGTC_39 0986-0283 58.349 µM -0.266563800073657 0.390106465639967 no 2072 0.39490251535263 3040 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1669 st015249 58.4 µM -0.266637122276211 0.390077280764298 no 2073 0.394874285302263 2959 722793 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.26697640787415 0.389942240953843 no 2074 0.394743662896558 2890 688664 SGTC_2370 9071495 200 µM -0.268913595749007 0.38917147140394 no 2075 0.393998087167164 2965 21791103 SGTC_596 1155-0152 116 µM -0.269582333657124 0.388905494594373 no 2076 0.393740796503459 2901 280313 SGTC_3292 9120825 59.784 µM -0.270479912585119 0.388548582805197 no 2077 0.393395534316537 3019 24824900 SGTC_1408 3909-7976 48.8 µM -0.273449426789302 0.3873684620971 no 2078 0.392253881435926 2931 24152374 SGTC_1327 1436-0082 2.18 µM -0.273823593094935 0.387219837458553 no 2079 0.392110095827807 2920 15992205 SGTC_2872 9044037 25.97 µM -0.273956910360688 0.387166885773685 no 2080 0.392058867878119 2862 6465195 SGTC_2417 cerulenin 830 nM -0.274135032982854 0.387096141327639 no 2081 0.391990426124599 2976 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1316 1272-0050 65.9 µM -0.274619743432463 0.386903649275875 no 2082 0.391804198133123 2891 7340392 SGTC_1539 benzyladenosine 56 µM -0.27610716274486 0.386313127371965 no 2083 0.391232879684175 2885 92208 A nucleotide analog. SGTC_827 3253-0474 693 µM -0.276179147371116 0.386284555346921 no 2084 0.391205236297552 3020 5402065 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.276863939206683 0.386012779700113 no 2085 0.390942291459431 2954 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2206 7254556 146.969 µM -0.27766286722916 0.385695777137104 no 2086 0.390635583874358 2932 4398905 SGTC_2184 6075246 200 µM -0.278472536745767 0.385374590384528 no 2087 0.390324822050723 2959 2267320 SGTC_637 1181-0519 7.26 µM -0.278534481890036 0.385350020679519 no 2088 0.390301049571229 2909 6252091 YGR060W ERG25 SGTC_603 3794-0023 45.9 µM -0.278854039726136 0.385223279690826 no 2089 0.39017842045371 3005 3802260 SGTC_1845 st056753 3.01 µM -0.28070753732818 0.384488399462957 no 2090 0.389467363579197 2839 5375839 SGTC_180 1486-1293 102.781 µM -0.281211719166697 0.384288571625943 no 2091 0.389274008305244 3007 4140536 SGTC_2868 9035608 32.47 µM -0.281251676382368 0.384272736265181 no 2092 0.389258685762802 2854 6462614 SGTC_1989 st071868 50.2 µM -0.282549033232605 0.383758688569078 no 2093 0.388761277183856 3047 16414057 SGTC_3231 9132313 49.47 µM -0.284868417916002 0.382840196042621 no 2094 0.387872476376212 2968 4905967 SGTC_2799 7812892 81.82 µM -0.285070041199144 0.382760382849329 no 2095 0.387795240910215 3069 20205235 SGTC_1123 mangostin 811.285 nM -0.285234611620533 0.382695240834679 no 2096 0.387732202507141 2976 5281650 An antioxidant. SGTC_2576 guaiol 23.12 µM -0.287113926012849 0.381951586370027 no 2097 0.387012544736833 3026 227829 SGTC_2014 4013930 200 µM -0.287529540648737 0.381787184191605 no 2098 0.386853443128242 2959 64556 SGTC_568 1193-0097 7.48 µM -0.288541868000931 0.381386833216301 no 2099 0.386465993281659 3014 3646150 SGTC_3032 9089427 49.47 µM -0.289192871519878 0.381129444082377 no 2100 0.386216893307234 3020 17173707 SGTC_2177 5811945 192 µM -0.289450828719139 0.381027469341025 no 2101 0.386118201535692 3076 5343475 SGTC_353 1988-1175 58.3 µM -0.290327653430649 0.38068090786063 no 2102 0.385782792546327 2837 2788357 SGTC_2120 5538279 151.968 µM -0.291586317012805 0.380183593469574 no 2103 0.385301469234278 2952 2058197 SGTC_223 busulfan 5 mM -0.292205482757623 0.379939025622899 no 2104 0.385064759925501 3007 2478 A DNA alkylator. SGTC_1165 k072-0275 30.3 µM -0.295462662088375 0.378653246254009 no 2105 0.383820235565536 3033 6153523 YGL055W OLE1 SGTC_2742 clothiapine 36.27 µM -0.296085496627846 0.37840753323689 no 2106 0.383582394847939 2980 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1760 st045453 10.4495 µM -0.296291413493244 0.378326308257135 no 2107 0.38350377138339 3058 3323419 YIL048W NEO1 SGTC_3165 9101544 49.47 µM -0.296304366176399 0.378321199183514 no 2108 0.383498825932178 3032 5002184 SGTC_1156 4092-0367 4.88 µM -0.296449443240499 0.378263976246561 no 2109 0.38344343549809 2953 1357585 SGTC_1274 0865-0114 173 µM -0.297931145296781 0.377679699650331 no 2110 0.382877858134469 2968 870624 SGTC_364 0083-0097 67.7 µM -0.298525330752603 0.377445474208796 no 2111 0.382651122915992 3065 5207356 SGTC_3318 9139014 38.6185 µM -0.299117975442713 0.377211901023431 no 2112 0.382425015696522 2918 16643984 SGTC_3252 9135871 49.47 µM -0.300152778460863 0.376804172079019 no 2113 0.382030311303126 3086 17682838 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.300303786789917 0.37674468385617 no 2114 0.381972722512034 3127 551469 SGTC_3219 9131112 49.47 µM -0.301780444336655 0.37616312379052 no 2115 0.38140971971015 3042 17612988 YMR079W SEC14 SGTC_2711 st079103 59.1 µM -0.302341999386329 0.37594203721171 no 2116 0.381195682308518 2990 54693780 SGTC_2200 6600604 21.907 µM -0.302357153453491 0.375936071555766 no 2117 0.381189906820321 2927 2904777 SGTC_3306 9127676 59.7925 µM -0.303217630752555 0.375597378732916 no 2118 0.380862006857466 3018 41905287 SGTC_839 0122-0028 230 µM -0.303894351379136 0.375331081763799 no 2119 0.380604190676653 2964 759448 SGTC_1862 st057513 3.81 µM -0.306621796759118 0.37425840549164 no 2120 0.379565630454007 2944 5393163 SGTC_2677 mitomycin C 100 µM -0.307340678535068 0.373975838303733 no 2121 0.379292037995093 2971 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2074 5212007 75.395 µM -0.309810073509586 0.37300572243194 no 2122 0.37835269536062 3047 758611 SGTC_3340 9146634 11.102 µM -0.310961097022159 0.372553810866542 no 2123 0.377915098250303 3035 4907387 SGTC_3105 9121040 49.47 µM -0.311064127203346 0.372513367994538 no 2124 0.377875935775593 2958 41448907 SGTC_1751 st044839 27.194 µM -0.312018639994286 0.372138755947408 no 2125 0.377513178677358 2956 5291326 SGTC_2707 st078556 66.6 µM -0.313355893747514 0.37161413533199 no 2126 0.377005144822783 3030 17250899 SGTC_3272 9137413 49.47 µM -0.31342523441715 0.371586938651391 no 2127 0.37697880752131 2923 17614870 SGTC_1245 0418-0076 17.2 µM -0.313547230998223 0.371539090913906 no 2128 0.376932471591705 3131 6790114 SGTC_317 4495-0002 170 µM -0.31376538407983 0.371453535010473 no 2129 0.376849618558754 2997 15991618 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.313986595655403 0.371366786102679 no 2130 0.376765609721767 2975 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1466 k213-0079 57.5 µM -0.315757651316471 0.370672496215081 no 2131 0.376093232053875 2957 3657981 SGTC_1058 3448-5425 97.3 µM -0.316532833163997 0.370368741450036 no 2132 0.37579905400838 2955 7279705 SGTC_249 wiskostatin 11.211 µM -0.316888774424513 0.370229293039051 no 2133 0.375664000060287 3044 2775510 A n-wasp and actin depolymerizer. SGTC_1125 tnp00248 1.32998 µM -0.317073857710216 0.370156789021089 no 2134 0.375593780366856 3124 24207736 SGTC_560 2332-1943 155 µM -0.318229906939214 0.369704025971852 no 2135 0.375155274280561 2952 21177716 SGTC_2699 st077704 54.6 µM -0.318375632387889 0.369646965861432 no 2136 0.375100009960013 3033 645852 SGTC_115 0527-0192 112.043 µM -0.320053609423029 0.368990145968945 no 2137 0.374463845843163 3063 4233931 SGTC_154 3389-1638 511.116 µM -0.32088672456297 0.368664177007883 no 2138 0.374148117322437 3043 5238686 SGTC_3064 1327-0027 10 µM -0.321490917994488 0.368427836231737 no 2139 0.373919196836284 2942 16000455 YPR107C YTH1 SGTC_3001 9076041 71.4286 µM -0.323178017068759 0.367768161837551 no 2140 0.373280214114248 2956 16004211 SGTC_2820 7989630 71.43 µM -0.323209984290556 0.367755666058029 no 2141 0.373268110000855 3047 2984098 SGTC_899 1083-0020 478 µM -0.323724425775116 0.367554593480734 no 2142 0.373073338368386 3153 767123 SGTC_613 3914-0030 117 µM -0.32390838129499 0.36748270215765 no 2143 0.373003699217459 2903 1145395 SGTC_166 k072-0058 166.424 µM -0.32457275644554 0.367223097600694 no 2144 0.372752224501182 3092 5846229 SGTC_2616 abietic acid 100 µM -0.326981858014226 0.366282251069303 no 2145 0.371840803439617 3139 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1644 st010134 20.9 µM -0.328499571786442 0.365689937673964 no 2146 0.3712669840025 3102 3818134 SGTC_2451 5856223 45.7 µM -0.329247269194291 0.3653982537426 no 2147 0.370984398563489 3015 2179896 SGTC_144 4161-2749 112.381 µM -0.330625178674005 0.364860922027703 no 2148 0.370463812511421 3010 797501 YMR168C CEP3 SGTC_2133 5320837 200 µM -0.331230502944571 0.36462495265188 no 2149 0.370235190705879 3135 2841355 SGTC_1143 3454-2408 5.08 µM -0.331326189221024 0.364587656623856 no 2150 0.370199055642395 2984 X1143 SGTC_59 0330-0160 1.33 µM -0.331428401861027 0.36454781820446 no 2151 0.370160457221753 3028 4293482 SGTC_2937 9044753 11.33 µM -0.331428527211842 0.364547769348599 no 2152 0.370160409886497 2939 6465530 YGL099W LSG1 SGTC_739 1486-1183 203 µM -0.332822873323822 0.364004455009849 no 2153 0.369633995609412 3129 4346692 SGTC_2441 5730946 39.09 µM -0.333847255730254 0.363605473036005 no 2154 0.36924741110859 3126 1774275 SGTC_1814 st052110 31.539 µM -0.334898380376804 0.363196229066086 no 2155 0.368850871949903 3138 674163 SGTC_2849 9019321 12.99 µM -0.33571322193561 0.362879086751963 no 2156 0.368543567134189 3121 16489627 SGTC_536 3852-0578 10.6 µM -0.336680830490666 0.362502608529202 no 2157 0.368178757804677 3147 2869208 SGTC_3004 9076122 71.4286 µM -0.338231077690391 0.361899713797461 no 2158 0.367594528939504 3147 44782551 SGTC_1170 0310-0127 64.8 µM -0.338632371136465 0.361743705599093 no 2159 0.367443346639986 3060 774975 SGTC_1736 st036774 51 µM -0.338668611385372 0.361729617848036 no 2160 0.367429694589371 3236 1272247 SGTC_1753 st043925 64 µM -0.339949486448234 0.361231820976412 no 2161 0.366947284356713 3118 670181 SGTC_2367 9070478 135.38 µM -0.340275088804471 0.361105316899434 no 2162 0.366824687651422 2960 572802 SGTC_3283 9109332 35.8195 µM -0.340585212387658 0.360984840808406 no 2163 0.366707931685758 3021 17027281 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.342139248134682 0.360381340513328 no 2164 0.366123051026199 3108 616764 SGTC_668 1682-0499 62.6 µM -0.343605958585224 0.359812071335408 no 2165 0.365571321487508 3047 682214 SGTC_2203 7227154 166.4 µM -0.343772176615844 0.359747577301739 no 2166 0.365508813100354 3038 896304 SGTC_673 1082-0474 110 µM -0.346672406752534 0.358622907151331 no 2167 0.364418721168236 3054 3098046 SGTC_3065 9113888 49.47 µM -0.347691597869746 0.358227968930293 no 2168 0.364035903686464 3204 16648368 SGTC_2288 7946289 167.31 µM -0.350031267593228 0.357321917277178 no 2169 0.363157616026053 3216 1246052 SGTC_904 1141-0088 396 µM -0.350273881314664 0.357228009514841 no 2170 0.36306658243173 3054 1378119 SGTC_2073 5212005 126 µM -0.351188341361636 0.356874129980085 no 2171 0.362723528023728 3000 691789 SGTC_733 4069-0007 56.1 µM -0.351360423642145 0.356807550999082 no 2172 0.362658984656545 3050 5717425 YNL287W SEC21 SGTC_1268 0828-0275 2.46 µM -0.351425955487123 0.356782197742916 no 2173 0.362634406475815 3117 745337 SGTC_155 k072-0202 43.6 µM -0.351457943472245 0.356769822316525 no 2174 0.362622409361919 3093 5857737 SGTC_1208 2323-2347 50.3 µM -0.351623689513269 0.35670570134463 no 2175 0.362560248365457 3185 5412760 SGTC_702 1488-0190 94 µM -0.352901173811594 0.35621162622869 no 2176 0.362081265402942 3114 949357 SGTC_2346 9031566 143.75 µM -0.353153146032866 0.356114202846854 no 2177 0.361986815815584 3096 4771086 SGTC_1562 morin hydrate 59.1 µM -0.353293437172135 0.356059964282096 no 2178 0.361934232548717 3197 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2634 4'-methoxyflavone 100 µM -0.353512431642712 0.355975303704046 no 2179 0.36185215527803 3079 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2461 5755302 26.15 µM -0.353606371128351 0.355938990026485 no 2180 0.361816949502508 3167 2788904 SGTC_1515 3460-0031 42.1 µM -0.354130279645476 0.355736489530259 no 2181 0.361620625347662 3062 2876596 SGTC_984 1492-0255 2.91 µM -0.355299246135956 0.355284808796886 no 2182 0.361182710083229 3138 1585198 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.356839841527035 0.354689843647219 no 2183 0.360605853973594 2951 4000243 SGTC_3190 9110366 49.47 µM -0.358478720153048 0.35405731124033 no 2184 0.359992545020393 3144 17123768 SGTC_2163 5671233 125 µM -0.359516306678984 0.353657058128643 no 2185 0.359604440584716 3267 701023 SGTC_2910 7948405 25.97 µM -0.36002188962278 0.353462086080571 no 2186 0.359415382052153 3207 2971328 SGTC_1632 st005650 90 µM -0.361645594216808 0.352836183934166 no 2187 0.358808444151462 3142 2759605 SGTC_389 tpck 16.7 µM -0.361717300677085 0.352808551848403 no 2188 0.358781648608215 3103 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_762 1165-0429 115 µM -0.361927349081533 0.352727614160698 no 2189 0.358703160920402 3156 5967793 SGTC_2388 9080168 200 µM -0.362796064418163 0.352392943997383 no 2190 0.358378616007832 3019 15943073 SGTC_1986 st071812 45 µM -0.36376363565458 0.352020324368755 no 2191 0.358017259741228 3132 11838594 SGTC_656 4090-1979 187 µM -0.364487931785501 0.35174148492725 no 2192 0.35774684199163 3175 22330961 SGTC_127 0180-0333 59.125 µM -0.36497216779596 0.351555108266565 no 2193 0.357566091086891 3080 771601 SGTC_3331 9141060 1.957 µM -0.366156545080837 0.351099406016992 no 2194 0.357124132941344 3043 4906567 YPR165W RHO1 SGTC_2533 agelasine 13.65 µM -0.366395589446116 0.351007456994119 no 2195 0.357034955193085 3253 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2394 5221648 200 µM -0.367511234532085 0.350578436713438 no 2196 0.356618856661216 3169 788586 SGTC_2220 6782180 200 µM -0.367565807209441 0.350557455724206 no 2197 0.356598507238834 3116 833803 SGTC_1777 st045864 34.765 µM -0.368258440395488 0.350291205882225 no 2198 0.356340269060711 3122 4691462 SGTC_1680 diphenhydramine 100 µM -0.369179705807451 0.349937183266454 no 2199 0.355996890768705 3081 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_17 0960-0276 49.807 µM -0.3692051887719 0.349927392559726 no 2200 0.355987394299155 3058 6821114 SGTC_2693 st077581 40.7 µM -0.371091073173873 0.349203101855527 no 2201 0.355284849838709 3197 25238761 SGTC_1837 st055472 66.5 µM -0.371374218360581 0.349094404752025 no 2202 0.355179412754312 3230 676091 SGTC_3048 9093155 49.47 µM -0.371654524782936 0.348986809620532 no 2203 0.355075043684001 3175 25236002 SGTC_852 0418-0143 439 µM -0.372775626537446 0.34855659812072 no 2204 0.354657722320632 3165 5369229 SGTC_3080 9117754 49.47 µM -0.374457678349752 0.347911493030787 no 2205 0.354031918893315 3274 9550191 SGTC_2374 9071832 200 µM -0.375830880375035 0.347385164956641 no 2206 0.353521314391972 3131 17381698 SGTC_3101 9120531 49.47 µM -0.378826655741034 0.346237950405645 no 2207 0.352408295850273 3269 24824904 SGTC_3051 9093778 49.47 µM -0.38094581682958 0.345427280548233 no 2208 0.3516217271195 3132 17217378 SGTC_2993 9054257 71.4286 µM -0.381100198720388 0.34536825050907 no 2209 0.351564449982267 3043 6470217 YGL055W OLE1 SGTC_1946 st076057 65.1 µM -0.381199215019017 0.345330392245112 no 2210 0.351527715775476 3044 953009 SGTC_790 1575-0012 79.1 µM -0.381934567273739 0.345049283342068 no 2211 0.35125494973208 3214 378741 YLR208W SEC13 SGTC_908 3448-7491 47.7 µM -0.382236422456895 0.344933915522007 no 2212 0.351143004004659 3050 1203031 SGTC_2445 5742597 35.57 µM -0.38249968477105 0.34483330950647 no 2213 0.351045381335985 3056 1774255 SGTC_245 methotrexate 289.6 µM -0.382833016982974 0.34470594193331 no 2214 0.350921789521018 3150 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2151 5563267 85.4165 µM -0.383242791369009 0.344549389617756 no 2215 0.350769876341074 3110 5310824 SGTC_1491 4138-0063 26.5 µM -0.383637095824971 0.344398772646843 no 2216 0.350623720755654 3168 23883227 SGTC_3342 9147791 14.508 µM -0.384886509105564 0.343921683043359 no 2217 0.350160750786975 3078 1838168 SGTC_709 3807-1509 243 µM -0.385115443666226 0.343834291077234 no 2218 0.350075943218437 3139 1886677 YPL242C IQG1 SGTC_2279 7948423 32.93 µM -0.385909606945938 0.343531197132995 no 2219 0.349781807710383 3251 1247112 SGTC_1871 st057448 67.3 µM -0.385990415326985 0.343500362093338 no 2220 0.349751883632192 3289 691747 SGTC_1915 st067105 30.6 µM -0.388211923165337 0.342653082741813 no 2221 0.348929605181794 3134 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2523 spermine 47.74 µM -0.388886385489991 0.342396000278152 no 2222 0.348680096915664 3180 1103 A DNA binding polyamine. SGTC_2618 avocadyne 43.43 µM -0.390954526712444 0.341608149656841 no 2223 0.347915424247645 3065 3015189 SGTC_123 0083-0120 66.675 µM -0.391417585222893 0.341431843617238 no 2224 0.347744297993467 3109 16001701 SGTC_2504 purpurogallin 52.29 µM -0.391599403238451 0.341362627234719 no 2225 0.34767711445277 3074 5281571 An antioxidant. SGTC_3245 9134821 49.47 µM -0.392045673428348 0.341192759060242 no 2226 0.347512233521533 3110 17014901 SGTC_1372 2752-0194 270 µM -0.392353724570163 0.341075521319403 no 2227 0.347398436428648 3120 823334 SGTC_2843 9000894 45.46 µM -0.392895487257654 0.34086937513577 no 2228 0.347198337382347 3145 2242070 SGTC_1805 st050013 60.3 µM -0.392915490516594 0.340861764602422 no 2229 0.347190950030615 3117 4037144 SGTC_1822 st052468 42 µM -0.393467112188753 0.340651917572413 no 2230 0.346987254946266 3151 2873678 SGTC_2292 7671323 168.05 µM -0.393616522138799 0.340595087763489 no 2231 0.346932090549691 3241 937504 SGTC_1277 0873-0036 22 µM -0.393744974840926 0.340546232179884 no 2232 0.346884666477113 3204 5965735 SGTC_732 3970-1727 52.7 µM -0.39382369281323 0.340516293980141 no 2233 0.346855605394557 3188 1275699 SGTC_3268 9137683 49.47 µM -0.394438018559748 0.340282686738549 no 2234 0.346628839721493 3073 1953228 SGTC_1075 aripiprazole 15.2 µM -0.396478576574788 0.339507172022008 no 2235 0.345876004575586 3088 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2478 5763493 32.33 µM -0.396631728019503 0.339448994124744 no 2236 0.34581952603586 3080 1365576 YLR208W SEC13 SGTC_598 3937-0236 20.2 µM -0.396756712425083 0.339401518923307 no 2237 0.345773437359477 3165 1379313 SGTC_2148 5546263 113.568 µM -0.396897188995928 0.339348162080717 no 2238 0.345721638591176 3086 792097 SGTC_254 nsc-64875 3.808 µM -0.397187999635593 0.339237714484622 no 2239 0.345614415418796 3259 56993 SGTC_2689 tacrolimus 100 µM -0.400145128315341 0.338115405953812 no 2240 0.344524813516099 3160 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_878 0828-0289 13.7 µM -0.401279901957422 0.337685110349084 no 2241 0.344107029480568 3123 745350 YLR208W SEC13 SGTC_2957 9076800 11.52 µM -0.401287787466029 0.337682120979006 no 2242 0.344104126976529 3126 16459615 SGTC_1892 st058411 7.36 µM -0.401359829372099 0.337654810606283 no 2243 0.344077610161916 3223 3934738 SGTC_3126 9127922 49.47 µM -0.401853249745735 0.337467782817646 no 2244 0.343896015141068 3307 45595682 SGTC_3200 9114385 49.47 µM -0.402014430661108 0.337406696934732 no 2245 0.343836703031602 3236 17018030 YLR208W SEC13 SGTC_3011 9081274 71.4286 µM -0.40207551805735 0.337383546569468 no 2246 0.343814224809137 3115 6625322 SGTC_1354 1498-1681 81 µM -0.404297822455565 0.336541776300544 no 2247 0.342996863282011 3198 5754243 SGTC_840 0245-0196 390 µM -0.405320403253902 0.336154715166941 no 2248 0.342621005389457 3254 3827528 SGTC_452 diindolylmethane 8 µM -0.405772282393628 0.335983727888101 no 2249 0.342454963135863 3205 3071 Inhibits expression of several cancer promoting factors. SGTC_1574 spiramycin 23.7 µM -0.410029261454751 0.334374592691961 no 2250 0.340892241271685 3074 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1082 camptothecin 424.86 nM -0.410153854365513 0.334327542282931 no 2251 0.340846544592392 2930 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_365 0121-0052 13.6 µM -0.4107794084313 0.334091351702415 no 2252 0.340617146752624 3238 3101739 SGTC_3289 9119912 71.43 µM -0.411487709477889 0.333823997627901 no 2253 0.340357475801178 3247 17014829 SGTC_1677 st019204 53.9 µM -0.412846204673625 0.333311458496135 no 2254 0.339859648369059 3203 3945625 SGTC_743 1275-0778 158 µM -0.413059291687921 0.333231092277115 no 2255 0.339781586861123 3209 2849257 YMR203W TOM40 SGTC_2814 7977482 42.97 µM -0.413936861568091 0.332900195667024 no 2256 0.339460173604742 3270 6456762 SGTC_951 1171-0579 82.7 µM -0.414171763411777 0.332811645608638 no 2257 0.339374159721308 3147 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_980 1473-0395 201 µM -0.415001101622729 0.332499087727917 no 2258 0.339070548339412 3096 768876 SGTC_198 3454-2873 16.191 µM -0.41563494562736 0.332260285450182 no 2259 0.338838575615072 3151 710957 SGTC_524 r073-0010 27.8 µM -0.416188202607588 0.332051900178975 no 2260 0.338636145881196 3084 2772106 SGTC_1128 3448-9350 235 µM -0.416870833895154 0.33179485740343 no 2261 0.338386443957258 3188 619386 SGTC_2622 2-methoxyxanthone 59.94 µM -0.417643907500724 0.331503854434075 no 2262 0.338103744638694 3145 71034 A hepatoprotective. SGTC_163 TUB2.036 7.546 µM -0.419374761886653 0.330852689288658 no 2263 0.337471132966087 3231 15992207 YJR013W GPI14 SGTC_1530 rhein 70.4 µM -0.41948185215572 0.330812417613974 no 2264 0.337432007501274 3159 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1014 4130-3005 69.3 µM -0.422473922360339 0.329688032066261 no 2265 0.3363395655715 3124 743608 SGTC_2565 isoliquiritigenin 100 µM -0.422753646985908 0.329582993209782 no 2266 0.336237505058943 3243 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_316 k060-0003 58.6 µM -0.4230781401351 0.329461160253303 no 2267 0.336119125393786 3248 6152314 SGTC_1474 0330-0125 5.35 µM -0.423109013232882 0.329449569700938 no 2268 0.336107863299913 3237 X1474 SGTC_1766 st045414 44.774 µM -0.423593334638878 0.329267764483236 no 2269 0.335931208578873 3160 253960 SGTC_2933 9026794 32.47 µM -0.423973981714294 0.329124904999738 no 2270 0.335792394177085 3161 17586027 SGTC_746 1095-0025 46.6 µM -0.424387838995209 0.328969609806572 no 2271 0.335641494093318 3308 6749286 SGTC_570 0987-0065 62.6 µM -0.424787157942494 0.328819797935056 no 2272 0.335495920078 3150 3104428 SGTC_1936 st074407 74.3 µM -0.426423374181361 0.328206228637275 no 2273 0.334899686119429 3138 809813 SGTC_1206 3978-0017 132 µM -0.426805650945873 0.32806294429454 no 2274 0.334760445104587 3376 3873677 SGTC_1811 st050069 61.5 µM -0.427110838441806 0.327948572582709 no 2275 0.334649299497109 3249 3877702 SGTC_1508 1080-0625 72.9 µM -0.427827492081931 0.32768006373428 no 2276 0.334388359845317 3204 767111 SGTC_2305 7443522 69.23 µM -0.427870422532808 0.32766398179527 no 2277 0.334372731043437 3153 5415886 SGTC_1731 st035964 63 µM -0.428277960668812 0.327511332111276 no 2278 0.334224381359238 3150 6739575 SGTC_1301 naphtanilide LB 4.81 µM -0.429553731041167 0.327033659166281 no 2279 0.333760150254502 3275 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_731 3966-0296 387 µM -0.430224861730526 0.326782488572041 no 2280 0.333516039280355 3143 660956 SGTC_66 0109-0187 42.4 µM -0.430493297376912 0.326682048522127 no 2281 0.333418420665361 3253 759417 SGTC_237 nikkomycin 200 µM -0.431042741351461 0.326476503296625 no 2282 0.33321864646615 3301 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_74 000s-0487 160.283 µM -0.431110767341751 0.326451058655535 no 2283 0.333193915955635 3242 677548 SGTC_1080 nisoldipine 24.4 µM -0.432291699019794 0.326009468279927 no 2284 0.332764709777264 3101 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3013 9080133 71.4286 µM -0.433259410211289 0.325647790056176 no 2285 0.332413161242181 3369 17050193 SGTC_338 4055-0136 114 µM -0.435037426535779 0.324983691341086 no 2286 0.331767630694826 3154 2900563 SGTC_1809 st050081 57.6 µM -0.436158255031284 0.324565341247632 no 2287 0.33136095660446 3325 5036894 SGTC_2670 beta-carotene 100 µM -0.43631163963427 0.324508107527446 no 2288 0.331305318988776 3242 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_983 1491-0821 12.2 µM -0.437391341706192 0.324105346312577 no 2289 0.330913781120148 3276 46495113 SGTC_1524 corynanthine 62.1 µM -0.438111965502315 0.323836646521761 no 2290 0.330652560480039 3304 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2270 7924575 90.91 µM -0.440166022484866 0.323071252065178 no 2291 0.329908433323754 3300 1262135 SGTC_1572 epiandrosterone 68.9 µM -0.44158227090702 0.322543957224662 no 2292 0.32939575782392 3181 441302 A steroid. SGTC_2076 5212012 200 µM -0.441616418451342 0.32253124787801 no 2293 0.329383400521826 3204 604802 SGTC_1786 berberine 21.6 µM -0.441617878645315 0.322530704414231 no 2294 0.329382872111467 3229 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1317 1273-0028 910 nM -0.442126343330055 0.322341484030702 no 2295 0.329198891249694 3185 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2347 9049783 174.81 µM -0.442304182848076 0.322275313575842 no 2296 0.32913455225764 3305 6467988 YPL169C MEX67 SGTC_188 3229-0966 278.469 µM -0.443503514551913 0.321829213866704 no 2297 0.328700788835067 3316 5722370 SGTC_2338 7999974 200 µM -0.443955568496218 0.321661135854797 no 2298 0.328537353889378 3191 315925 SGTC_3182 9108849 49.47 µM -0.44466098458463 0.321398928272846 no 2299 0.328282384281594 3285 17133045 SGTC_122 0236-0016 402.397 µM -0.444951222080815 0.321291071004664 no 2300 0.328177502401086 3236 6808838 SGTC_2223 6903751 107.57 µM -0.445078712433698 0.321243698149951 no 2301 0.328131436039328 3248 5598863 SGTC_2155 5570423 76 µM -0.449121373122351 0.319743038346545 no 2302 0.326672051557073 3186 797402 SGTC_2194 5927483 104.545 µM -0.450821195443283 0.319112932423795 no 2303 0.32605921191897 3189 760979 SGTC_88 0180-0332 8.668 µM -0.451179809455109 0.318980064704882 no 2304 0.325929980160463 3181 3101745 SGTC_2289 7946404 165.07 µM -0.451399097269424 0.3188988292766 no 2305 0.32585096691777 3166 1246120 YPR165W RHO1 SGTC_1106 tegaserod maleate 11.7 µM -0.452233643506285 0.318589750221875 no 2306 0.325550336826704 3234 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2090 5301565 104.445 µM -0.452236546216497 0.318588675406347 no 2307 0.325549291376058 3215 2056344 SGTC_3180 9109287 49.47 µM -0.453309247560436 0.31819158013393 no 2308 0.325163037390382 3285 18891271 SGTC_57 miconazole 162.5 nM -0.454430245301631 0.317776829548432 no 2309 0.324759593685911 3252 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.456332709395931 0.317073472577985 no 2310 0.324075373059422 3143 688667 SGTC_2747 doxorubicin 7.63 µM -0.456908497756909 0.316860728841535 no 2311 0.323868407907193 3203 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3218 9131285 49.47 µM -0.456956132961398 0.316843131176604 no 2312 0.323851288033819 3384 17156417 SGTC_2407 paclitaxel 400 µM -0.457606220350264 0.316603013670865 no 2313 0.32361768687448 3351 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_887 0885-0007 9.62 µM -0.458485287644599 0.316278442606934 no 2314 0.323301915031297 3309 5719458 SGTC_684 1140-0066 328 µM -0.458898643757492 0.316125871292403 no 2315 0.323153476375336 3284 6813534 SGTC_587 k089-0003 57 µM -0.45919357024226 0.316017031939294 no 2316 0.323047583717313 3288 9659696 SGTC_774 k060-0086 136 µM -0.459346674394863 0.315960536833801 no 2317 0.322992617686703 3360 5911235 SGTC_2650 prasterone 100 µM -0.460324132646901 0.315599958181848 no 2318 0.32264179086429 3268 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2190 6049624 200 µM -0.462337573184152 0.314857764998269 no 2319 0.321919629576867 3270 2265554 SGTC_1619 st003326 88.7 µM -0.464552748862487 0.314042071452739 no 2320 0.321125888276512 3335 2849032 SGTC_873 0591-4978 488 µM -0.465400180963527 0.313730261569304 no 2321 0.320822452309573 3404 3305145 SGTC_2962 9082311 13.18 µM -0.465692413940383 0.313622766226808 no 2322 0.320717841578639 3179 16459453 SGTC_2276 7947513 42.08 µM -0.465839570242916 0.313568642058711 no 2323 0.320665169379235 3260 2105100 SGTC_1066 ketoconazole 628 nM -0.466374685698796 0.313371860141408 no 2324 0.320473663969195 3344 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_124 0136-0217 7.121 µM -0.467246154728873 0.31305150217356 no 2325 0.320161887718347 3402 3976905 SGTC_3128 9127691 49.47 µM -0.468206686716251 0.312698567497027 no 2326 0.319818395410162 3302 41316314 SGTC_1840 st055363 71 µM -0.468350283318658 0.312645819581345 no 2327 0.319767057621989 3261 676033 SGTC_2536 dehydroabietamide 32.04 µM -0.468753116582101 0.312497865707142 no 2328 0.319623057542478 3357 3983547 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.473650414958941 0.310701592946769 no 2329 0.317874609015449 3229 4330530 SGTC_1064 honokiol 6.76 µM -0.475022315264031 0.310199201236593 no 2330 0.31738553391658 3290 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_745 0469-0705 296 µM -0.475429955594756 0.31004999099107 no 2331 0.317240273695112 3452 3486736 SGTC_2694 st077685 81.9 µM -0.477570209917254 0.309267098627851 no 2332 0.31647806903833 3169 2838096 SGTC_151 3013-0144 2.285 µM -0.479445466428833 0.308581851781532 no 2333 0.315810877470082 3360 906558 YHR107C CDC12 SGTC_268 camptothecin 39.6153 µM -0.481751512307469 0.307740101328059 no 2334 0.314991238929941 3332 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_836 0330-0104 1.35 µM -0.4828192614795 0.307350694775198 no 2335 0.314612036580015 3298 46494820 SGTC_1407 3909-7909 12.3 µM -0.484634011407551 0.306689356284291 no 2336 0.313967991586869 3300 4411780 SGTC_2925 9010536 32.5 µM -0.485031922129119 0.306544432037144 no 2337 0.313826850836595 3267 2994177 SGTC_477 mead ethanolamide 10 µM -0.48540389842208 0.306408980798552 no 2338 0.313694933778701 3259 16061185 SGTC_1610 st001799 48.1 µM -0.485562391735692 0.306351275166464 no 2339 0.313638733206918 3183 621897 SGTC_2474 5321570 43.32 µM -0.485929179329777 0.306217750350009 no 2340 0.313508689591653 3316 2841384 SGTC_998 3996-0085 177 µM -0.485982044245344 0.306198507605426 no 2341 0.313489948379911 3257 715391 SGTC_1798 st045719 60.953 µM -0.486590143858259 0.305977198777464 no 2342 0.31327440480821 3325 3980186 SGTC_691 1548-0686 185 µM -0.49156261579999 0.304170204041475 no 2343 0.31151428845018 3276 46495133 SGTC_271 rotenone 740 µM -0.492302864523855 0.303901604946659 no 2344 0.311252627709409 3381 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_544 k015-0020 52.4 µM -0.492316218551495 0.303896760411993 no 2345 0.311247908245759 3303 3008304 SGTC_776 4476-4378 112 µM -0.492982181021659 0.303655208218236 no 2346 0.311012588983809 3353 2892008 SGTC_2781 5567276 71.43 µM -0.493015738912337 0.303643038656485 no 2347 0.311000733275009 3386 2853274 SGTC_1063 disulfiram 1.84 µM -0.494274876288864 0.303186577709087 no 2348 0.310556032911182 3312 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2497 7-hydroxyflavone 100 µM -0.495160805961932 0.302865595583008 no 2349 0.310243307306836 3375 5281894 SGTC_411 enrofloxacin 100 µM -0.496136769021043 0.302512169594274 no 2350 0.309898959465551 3429 71188 A bacterial gyrase inhibitor. SGTC_1470 k295-0292 231 µM -0.496177748097388 0.302497333866284 no 2351 0.309884504513512 3363 5045612 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.496598973929795 0.302344855640638 no 2352 0.309735938429769 3289 2374 Ca(2+)-ATPase inhibitor. SGTC_1462 k081-0014 26.5 µM -0.496599610319591 0.302344625301965 no 2353 0.309735713998996 3253 3270634 SGTC_2021 4019055 173 µM -0.49809160710285 0.301804819779414 no 2354 0.309209737941042 3420 44827708 YER133W GLC7 SGTC_487 nimodipine 119 µM -0.49813577649697 0.301788845864233 no 2355 0.309194172783113 3281 4497 L-type voltage-gated calcium channels inhibitor SGTC_1284 0929-0043 16 µM -0.498253936137473 0.301746115154631 no 2356 0.309152535374667 3306 1239883 SGTC_3104 9120930 49.47 µM -0.498665796102386 0.301597193277779 no 2357 0.309007422230462 3373 17014836 SGTC_1167 k781-0610 148 µM -0.499101151649704 0.301439811733599 no 2358 0.308854063143064 3289 4525169 SGTC_748 act1.228 77.9 µM -0.499341580382949 0.301352912309171 no 2359 0.308769383587569 3308 4421505 YNR035C ARC35 SGTC_3235 9132602 49.47 µM -0.499897885982401 0.301151887097532 no 2360 0.308573490448684 3409 4912240 SGTC_244 nsc-207895 1.295 µM -0.501082509588137 0.300724015902222 no 2361 0.308156527829826 3258 42640 SGTC_1344 1488-0097 29.1 µM -0.502814358097664 0.300098988135937 no 2362 0.307547398945609 3371 747966 SGTC_1312 1218-2183 165 µM -0.503447072107679 0.299870786954913 no 2363 0.307324991794701 3392 6744073 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.506309560959745 0.298839355167284 no 2364 0.306319676086638 3370 4213774 SGTC_3127 9126946 49.47 µM -0.508798053604142 0.297943996376297 no 2365 0.30544689192822 3310 27243249 SGTC_2832 7992762 51.95 µM -0.508819846497219 0.297936160705157 no 2366 0.305439253421688 3167 2985177 SGTC_2829 7992743 58.44 µM -0.509843458484149 0.297568225189365 no 2367 0.305080568307936 3363 16462845 SGTC_1233 0325-0408 14.2 µM -0.509884414869038 0.297553507805859 no 2368 0.305066220623482 3393 12874 SGTC_3238 9133470 49.47 µM -0.510192092005276 0.297442956857333 no 2369 0.304958445924448 3409 3534688 SGTC_1423 4048-0112 5.59 µM -0.510959152330208 0.297167427426234 no 2370 0.304689829840097 3383 X1423 SGTC_2784 7567673 72.73 µM -0.511556396328495 0.296952977145692 no 2371 0.304480754443296 3417 3471247 SGTC_3321 9137793 26.8275 µM -0.513857330913372 0.29612745133347 no 2372 0.303675870738557 3378 4904192 SGTC_2164 5685496 200 µM -0.514691299993538 0.295828501395336 no 2373 0.303384376938273 3410 759046 SGTC_669 0108-0021 26.2 µM -0.516683461858209 0.295114939902846 no 2374 0.302688571345775 3570 17201 SGTC_1191 1487-1166 10.6 µM -0.51759745997095 0.294787825410088 no 2375 0.302369577178008 3400 3955771 SGTC_2804 7954240 19.48 µM -0.517774654640713 0.294724427841545 no 2376 0.302307751981229 3405 828705 SGTC_1682 st012968 530 nM -0.518420910270689 0.294493260667461 no 2377 0.302082314261009 3261 24207270 SGTC_467 ro 31-8220 72.8 µM -0.518461362578265 0.294478793564329 no 2378 0.302068205519785 3305 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_197 4544-0043 41.561 µM -0.518789023641894 0.294361623059775 no 2379 0.30195393653902 3372 896523 SGTC_514 4466-0038 2.65 nM -0.519549514539843 0.29408975704583 no 2380 0.301688796740803 3303 5722064 SGTC_3151 9099821 49.47 µM -0.520534129215055 0.293737942070038 no 2381 0.301345673371065 3376 17174189 SGTC_955 1216-0110 33 µM -0.520935670079431 0.293594522493703 no 2382 0.301205792889972 3362 3619719 SGTC_630 4356-0227 183 µM -0.522166224498019 0.293155203667543 no 2383 0.300777300139639 3387 779312 SGTC_3116 9124943 49.47 µM -0.524307400324811 0.29239151247153 no 2384 0.300032375278299 3318 41905195 YPL160W CDC60 SGTC_2862 9027634 71.43 µM -0.524836402779492 0.292202976251521 no 2385 0.299848461566414 3267 5012562 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.527615436768846 0.29121346016764 no 2386 0.298883138301062 3330 6708784 An antioxidant flavonoid SGTC_634 1611-4317 11.2 µM -0.528038880257925 0.291062824313218 no 2387 0.298736175312861 3451 2843522 SGTC_1411 3909-8223 150 µM -0.53113412791919 0.289962827408476 no 2388 0.297662918077507 3424 X1411 SGTC_423 5-fluorouracil 457 µM -0.531699913875877 0.289761967880915 no 2389 0.297466925797555 3273 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1694 st024011 44.9 µM -0.53178637064868 0.289731280635307 no 2390 0.297436981747729 3439 2787533 SGTC_2669 eugenol 100 µM -0.531907912727962 0.289688142677101 no 2391 0.297394888332961 3381 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3179 9107801 49.47 µM -0.533750575760397 0.289034510604168 no 2392 0.296757056305885 3348 4818259 SGTC_1513 0337-0559 19 µM -0.534271672125844 0.288849792465074 no 2393 0.296576794097244 3302 775073 SGTC_132 0417-1715 25.805 µM -0.534955543833301 0.288607458099311 no 2394 0.296340299364547 3482 6769098 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.535578507924785 0.288386790135294 no 2395 0.296124942833244 3377 6708561 SGTC_306 1672-3436 11.6 µM -0.537691772301189 0.28763881730465 no 2396 0.295394930209882 3431 6797378 SGTC_1085 doxorubicin 7.67 µM -0.537735961658713 0.28762318663068 no 2397 0.295379674141578 3435 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1674 st016616 23.6 µM -0.537794273075746 0.287602561311658 no 2398 0.295359543085269 3315 625830 SGTC_2482 5981709 142.65 µM -0.538857724799417 0.287226530724892 no 2399 0.29499251468406 3347 877755 SGTC_559 1550-0661 158 µM -0.54094274116267 0.286489956696906 no 2400 0.29427352487061 3423 5830875 SGTC_2997 9067075 71.4286 µM -0.543779080099142 0.285489404087614 no 2401 0.293296753176521 3397 27209819 SGTC_2204 7233102 200 µM -0.544271224928729 0.285315963609192 no 2402 0.293127422610114 3342 2172480 SGTC_844 0330-0132 15.3 µM -0.544804197115949 0.285128191483677 no 2403 0.292944095867353 3462 2828079 SGTC_2701 st077767 14.721 µM -0.545650749574853 0.284830062625362 no 2404 0.292653016165805 3402 5721188 SGTC_2345 9052315 157.45 µM -0.546010776741907 0.284703317598072 no 2405 0.292529264687826 3426 6469265 SGTC_118 0083-0097 135.343 µM -0.546196246142837 0.284638034910667 no 2406 0.292465523123112 3498 5207356 SGTC_1218 1348-1416 30.7 µM -0.546494417458614 0.284533097677051 no 2407 0.292363062038939 3410 6787668 SGTC_108 0509-0257 621.132 µM -0.546802954996416 0.284424531652043 no 2408 0.292257056368718 3374 536624 SGTC_2202 7226349 200 µM -0.548362786798691 0.283875972146872 no 2409 0.291721411613653 3341 844334 SGTC_2005 4024620 188 µM -0.54851777117921 0.283821495122967 no 2410 0.291668215122559 3445 236743 SGTC_1090 efavirenz 20.7 µM -0.54853109051776 0.283816813607804 no 2411 0.291663643633677 3431 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1689 st020265 53.493 µM -0.552645939294183 0.282372288916016 no 2412 0.290252939164856 3467 5758320 YPR016C TIF6 SGTC_2724 maprotiline 69.64 µM -0.553393206559124 0.28211033941398 no 2413 0.289997094871039 3462 4011 A tricyclic antidepressant. SGTC_2524 avocatin b 10.57 µM -0.5539073820121 0.281930166648831 no 2414 0.289821116395341 3400 6710748 SGTC_1163 k060-0048 49.9 µM -0.556160084251081 0.281141449001995 no 2415 0.289050711767356 3440 6809982 SGTC_2617 dihydrotanshinone i 20.83 µM -0.558094639173886 0.280464973024055 no 2416 0.288389880541558 3390 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_615 k087-0205 167 µM -0.559397633861048 0.280009785807412 no 2417 0.287945187924489 3384 9642773 SGTC_1587 estradiol valerate 56.1 µM -0.55947845836461 0.279981562434983 no 2418 0.287917614396425 3479 13791 A steroid. SGTC_591 4299-0174 154 µM -0.561224431015894 0.279372217480872 no 2419 0.287322275044988 3377 5509088 SGTC_2149 5554786 194.827 µM -0.561638732792847 0.27922772067258 no 2420 0.287181092543613 3405 745063 YPR165W RHO1 SGTC_1376 2910-0861 41.3 µM -0.5624411023107 0.278947980086212 no 2421 0.286907760792984 3450 1112859 SGTC_2767 sibutramine 71.45 µM -0.562911479000626 0.27878404991733 no 2422 0.286747581623484 3523 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1122 capsaicin 818.572 nM -0.563071653979555 0.278728238315688 no 2423 0.286693046304307 3475 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2314 7727897 200 µM -0.563400561646831 0.278613650306583 no 2424 0.286581077413513 3368 900724 SGTC_1067 clotrimazole 1.36 µM -0.563451177741879 0.278596018222799 no 2425 0.286563848194522 3414 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_572 0960-0087 17.7 µM -0.563732517695847 0.278498023538994 no 2426 0.286468091808762 3404 6796365 SGTC_1417 3966-0327 90.4 µM -0.564393014110051 0.278268029308514 no 2427 0.286243346062307 3446 651118 SGTC_1882 5615643 20 µM -0.568022992093023 0.277005674936609 no 2428 0.285009677963825 3430 2253075 SGTC_1219 1469-0211 33.1 µM -0.568184443821629 0.27694959396352 no 2429 0.284954866643232 3458 6822282 SGTC_3014 9081533 49.47 µM -0.568317520503498 0.276903373368248 no 2430 0.284909692160125 3488 21367265 SGTC_540 1187-0821 17.3 µM -0.568828474006846 0.276725942555355 no 2431 0.28473627458288 3385 847520 SGTC_925 2064-1272 59.6 µM -0.571420028647149 0.275826872714938 no 2432 0.283857477809592 3390 6815817 SGTC_2277 7947813 106.88 µM -0.573114474719838 0.275239807476853 no 2433 0.283283593601276 3551 1246798 SGTC_2823 7987624 58.44 µM -0.573812405485425 0.274998178297073 no 2434 0.283047376523639 3555 2239440 SGTC_3242 9133940 49.47 µM -0.57432082930199 0.274822223746832 no 2435 0.282875358268914 3521 17248444 SGTC_1202 1988-0068 29.6 µM -0.576553898977285 0.274050064131834 no 2436 0.282120424741887 3388 2850480 SGTC_1437 4092-1038 11.6 µM -0.57696191405927 0.273909094991539 no 2437 0.281982592024064 3446 3977136 SGTC_1787 fluconazole 80 µM -0.578456088229473 0.273393164280017 no 2438 0.281478117925081 3443 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_759 3486-0358 89.3 µM -0.58193791530593 0.272192777425628 no 2439 0.280304250218208 3540 875103 SGTC_2000 st075254 36.4 µM -0.581987551497659 0.272175683920641 no 2440 0.280287532963622 3458 17234175 SGTC_788 1182-0090 188 µM -0.582444333794158 0.272018404188315 no 2441 0.280133713336851 3560 5715185 SGTC_125 0133-0007 11.75 µM -0.582935062266001 0.271849486450288 no 2442 0.279968508063366 3564 26541 SGTC_1149 3909-7961 23.3 µM -0.585247389346097 0.271054244108817 no 2443 0.279190692267116 3466 735261 SGTC_885 0865-0106 16.8 µM -0.58662402213692 0.270581352068083 no 2444 0.278728122737876 3466 2793380 SGTC_78 0336-0123 156.75 µM -0.58827571501003 0.270014517539861 no 2445 0.278173621664277 3332 6765896 SGTC_1308 1187-1617 41.4 µM -0.589021699836699 0.269758702428004 no 2446 0.277923358489899 3501 2882570 SGTC_1340 1486-1359 257 µM -0.589556935985581 0.269575232628195 no 2447 0.277743865068407 3413 4309068 SGTC_903 1134-0042 114 µM -0.591418981617202 0.26893744274101 no 2448 0.277119862601167 3438 701009 SGTC_1382 3002-2117 298 µM -0.59267909164924 0.268506258714327 no 2449 0.276697968340254 3569 1497314 SGTC_1848 st056003 16.4 µM -0.59363342729292 0.268179935893117 no 2450 0.276378659206313 3554 146492 SGTC_263 alizarin 107.927 µM -0.594546282953266 0.267867983477412 no 2451 0.276073397994996 3508 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2487 5918373 44.05 µM -0.594702612090786 0.267814579072261 no 2452 0.276021137747817 3572 2876279 SGTC_1594 piperine 70.1 µM -0.596083104619653 0.267343214821543 no 2453 0.275559855223128 3494 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3293 9120939 62.045 µM -0.596793665190878 0.267100759712524 no 2454 0.27532257394257 3519 934087 SGTC_2800 7887935 81.82 µM -0.596841252167904 0.267084526210082 no 2455 0.275306686562955 3507 2961002 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.5978614034455 0.266736638488814 no 2456 0.27496620759991 3530 5377381 SGTC_1196 1588-0294 184 µM -0.598103883801939 0.266653982553738 no 2457 0.274885309483011 3489 6144269 SGTC_2093 5331342 194.4 µM -0.598189329244835 0.266624859267849 no 2458 0.27485680532811 3534 33839 SGTC_1453 4237-0541 195 µM -0.598583369031433 0.266490575277368 no 2459 0.274725374559749 3500 739892 SGTC_126 0417-1624 672.48 µM -0.598596040054168 0.266486257713941 no 2460 0.274721148693109 3604 41912 YDL195W SEC31 SGTC_1982 st072467 71.9 µM -0.599637111039323 0.266131640892597 no 2461 0.274374054442734 3422 3163533 SGTC_1887 st057648 70.8 µM -0.599760228808615 0.266089719469369 no 2462 0.274333021156765 3526 688672 SGTC_2265 7929201 200 µM -0.599912526188891 0.266037867057998 no 2463 0.274282266940937 3486 1265108 SGTC_868 0527-0199 213 µM -0.600973663225551 0.265676725780968 no 2464 0.273928764012262 3411 2849450 SGTC_3194 9111903 49.47 µM -0.601592997402307 0.265466060090026 no 2465 0.273722545648122 3553 17087251 SGTC_2428 5615643 7.78 µM -0.602222745209176 0.265251939155712 no 2466 0.27351293864868 3512 2253075 SGTC_1384 3089-0840 101 µM -0.603703584862866 0.26474878371777 no 2467 0.273020365163037 3511 1069836 SGTC_721 1187-1332 279 µM -0.604227308229106 0.264570950739156 no 2468 0.272846263752761 3464 25730 SGTC_2892 9047358 58.44 µM -0.605638606128347 0.264092039949627 no 2469 0.272377380162741 3460 6466771 SGTC_1521 st012942 49.4 µM -0.605933879335077 0.263991897636802 no 2470 0.272279330508056 3528 24207259 SGTC_580 1123-0028 41 µM -0.606598931396376 0.263766415221205 no 2471 0.27205855479718 3584 1677248 YPR107C YTH1 SGTC_1920 st075728 45.7 µM -0.606646493277521 0.263750293378661 no 2472 0.272042769206632 3559 3400306 SGTC_1727 st034309 9.9045 µM -0.606904851283846 0.263662727676923 no 2473 0.271957029216053 3573 870305 SGTC_1310 1188-0297 994 nM -0.607633771089425 0.263415753666785 no 2474 0.271715198692589 3499 1588352 SGTC_1853 st056710 91.2 µM -0.608493274372775 0.263124686919959 no 2475 0.271430182650007 3593 269167 SGTC_813 k007-0158 173 µM -0.608556497230175 0.26310328328676 no 2476 0.27140922348331 3516 6523916 SGTC_723 4182-0001 115 µM -0.60971336231826 0.262711792262492 no 2477 0.271025850690237 3463 744821 YLR208W SEC13 SGTC_655 k060-0012 42 µM -0.612320936760987 0.261830465492584 no 2478 0.270162720060478 3465 5994525 SGTC_3325 9138760 55.175 µM -0.613048131704749 0.261584953620618 no 2479 0.269922257387015 3477 43844959 SGTC_1618 st003135 44.5 µM -0.613052949965888 0.261583327297855 no 2480 0.269920664482502 3492 1270615 SGTC_1006 4099-6547 255 µM -0.613445413717622 0.261450875209693 no 2481 0.269790932796471 3539 3146833 SGTC_3347 9188721 44.724 µM -0.613449829874004 0.2614493850027 no 2482 0.269789473182211 3524 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1159 4092-0538 61.2 µM -0.614613953978826 0.26105671007534 no 2483 0.26940484846772 3574 717301 SGTC_1830 st055982 50.3 µM -0.615594052966476 0.260726344571427 no 2484 0.269081238641924 3525 455313 An antimicrobial agent. SGTC_2116 5511452 16.8835 µM -0.616201404188804 0.260521730520776 no 2485 0.268880800897896 3530 870744 SGTC_2783 7738165 71.43 µM -0.617096663302192 0.260220272355329 no 2486 0.268585484706012 3476 17201110 SGTC_1484 3473-2379 286 µM -0.617833216226291 0.259972389752693 no 2487 0.268342642695562 3644 671917 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.617984286778503 0.259921562891302 no 2488 0.268292848281291 3508 115019 SGTC_253 dyclonine 31.25 µM -0.618682829827893 0.259686608564027 no 2489 0.268062661731189 3582 3180 An oral anasthetic. SGTC_726 3448-4391 34.2 µM -0.619409696984555 0.2594422438824 no 2490 0.26782324730578 3636 1356692 SGTC_2140 5586273 200 µM -0.620804749594553 0.258973575613498 no 2491 0.267364048915503 3538 854421 SGTC_2226 7298446 200 µM -0.621303605669258 0.258806091146785 no 2492 0.267199940883719 3550 3283010 SGTC_2499 avocadenofuran 51.48 µM -0.621589872028628 0.258710006241638 no 2493 0.267105791176632 3446 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_312 4092-0653 6.84 µM -0.621963064801107 0.258584772339774 no 2494 0.26698307752849 3541 1148278 SGTC_3355 9151058 44.0485 µM -0.62282309213865 0.258296288843968 no 2495 0.266700390875082 3567 17015728 SGTC_2411 st077133 39.94 µM -0.623456978140851 0.258083767949582 no 2496 0.266492132637626 3653 1403142 YNL221C POP1 SGTC_3056 9094900 49.47 µM -0.625012419765272 0.257562664609533 no 2497 0.265981453382318 3489 25236784 SGTC_3210 9128157 49.47 µM -0.62579618067366 0.257300296587115 no 2498 0.265724318651516 3467 17590849 SGTC_3174 9107204 49.47 µM -0.625815875556371 0.257293705412775 no 2499 0.265717858816905 3596 3938802 SGTC_1247 0448-0043 5.84 µM -0.625973063094443 0.257241103499164 no 2500 0.265666304851792 3561 3089013 YGL099W LSG1 SGTC_2713 st079149 53.4 µM -0.626117254991385 0.257192855419459 no 2501 0.265619017624365 3549 3103253 SGTC_1193 1488-0126 41.5 µM -0.626434410620748 0.257086748468077 no 2502 0.265515022569084 3581 1384710 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.628571968831113 0.256372205518934 no 2503 0.264814658248115 3540 5355888 SGTC_2128 5255449 168.493 µM -0.628935146059328 0.256250905580439 no 2504 0.264695757761945 3547 736008 SGTC_2586 curcumin 80 µM -0.629826549951815 0.255953306653795 no 2505 0.26440403644629 3557 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_877 0771-0151 33.1 µM -0.63038375624791 0.255767372631128 no 2506 0.264221767969305 3521 6166523 SGTC_2099 5377090 177.372 µM -0.630909352883076 0.255592051075866 no 2507 0.264049898036396 3541 2243829 SGTC_315 k915-0449 187 µM -0.631208833598153 0.255492182350484 no 2508 0.263951993420252 3564 20970215 YNL149C PGA2 SGTC_1883 5-benzylidenerhodanine 20 µM -0.632925559981309 0.254920094133391 no 2509 0.263391127759405 3556 1273210 SGTC_215 1287-0124 461.5 µM -0.63315345950259 0.254844198493286 no 2510 0.263316717279509 3545 5560863 SGTC_1183 1254-0324 198 µM -0.63570278921442 0.253996021460034 no 2511 0.262485079048302 3585 5799357 SGTC_102 gallobenzophenone 83.616 µM -0.63684919195703 0.253615089865198 no 2512 0.262111540153567 3621 70837 SGTC_821 1114-0266 29.2 µM -0.637124252173136 0.253523736341268 no 2513 0.262021956267193 3569 3123235 SGTC_1223 0764-0573 147 µM -0.63799436841182 0.253234865563807 no 2514 0.261738673005601 3600 1609797 SGTC_346 4513-0042 7.16 µM -0.638224263137952 0.25315857149465 no 2515 0.261663852558265 3581 2827372 SGTC_3150 9097574 49.47 µM -0.638635298298335 0.253022193347144 no 2516 0.261530106364253 3553 17217476 SGTC_2496 diffractaic acid 79.83 µM -0.638966417318034 0.252912358848569 no 2517 0.26142238950801 3644 94870 An apoptosis inducer which activates caspases. SGTC_1988 st071872 53.4 µM -0.639211740859163 0.252830999497186 no 2518 0.261342597611229 3595 16414116 SGTC_68 0986-0284 82.829 µM -0.639646656439289 0.252686797518622 no 2519 0.261201171336356 3554 423278 YIL048W NEO1 SGTC_1152 3909-8331 15.9 µM -0.639847171463575 0.252620328717387 no 2520 0.261135980912362 3563 16001939 SGTC_2064 5220758 200 µM -0.642456661362857 0.251756148443131 no 2521 0.260288360041078 3635 788518 SGTC_2425 5628681 7.85 µM -0.642766613785383 0.25165360585046 no 2522 0.26018777481226 3585 5714958 SGTC_641 4092-0595 30 µM -0.643747589165413 0.251329211948484 no 2523 0.259869562452964 3594 786260 SGTC_2977 9011197 71.43 µM -0.64432206426377 0.25113934430351 no 2524 0.259683305389498 3607 2704722 SGTC_801 0866-0028 10.1 µM -0.644676764093238 0.251022151666762 no 2525 0.259568338565785 3622 6849771 SGTC_326 k292-0812 17.5 µM -0.644821660154126 0.250974286410509 no 2526 0.259521381797394 3550 3579357 SGTC_810 3825-7150 143 µM -0.645086247657586 0.250886894506284 no 2527 0.25943564769395 3621 22330411 YGL099W LSG1 SGTC_275 trichlorophene 5.69 µM -0.645461134272104 0.250763098952464 no 2528 0.259314198500525 3597 62616 SGTC_2207 7258803 200 µM -0.645790132726637 0.250654483301451 no 2529 0.259207639557452 3556 3666799 SGTC_1684 st024538 14.6195 µM -0.647661452898613 0.250037159341082 no 2530 0.258601970521579 3560 6732859 SGTC_804 1595-0054 20.9 µM -0.647775146655579 0.249999679274407 no 2531 0.258565196176412 3576 761523 Stimulates phospholipase C. SGTC_1947 st076332 61.6 µM -0.64783771784283 0.249979053448275 no 2532 0.258544958626517 3571 24208416 SGTC_3299 9121982 43.1275 µM -0.64961005833608 0.249395198334905 no 2533 0.257972067143906 3577 17594604 YPL160W CDC60 SGTC_2320 7373003 200 µM -0.649799372688605 0.249332876131498 no 2534 0.257910912106809 3586 5415828 SGTC_3040 9091894 49.47 µM -0.65029098119435 0.249171077495636 no 2535 0.257752140811151 3527 25236966 SGTC_304 1310-0298 97 µM -0.651212670329239 0.24886788089035 no 2536 0.257454606223324 3557 1550234 SGTC_519 k048-0011 62.8 µM -0.651797525034047 0.248675590410179 no 2537 0.257265899239672 3590 6836379 SGTC_397 arbidol 50 µM -0.652510510725203 0.248441279671785 no 2538 0.257035947289497 3626 131410 A RNA synthesis inhibitor. SGTC_1866 st057638 64 µM -0.653165647721124 0.248226083703449 no 2539 0.256824746974027 3591 688802 SGTC_470 aa-861 153 µM -0.654950820439929 0.247640204318388 no 2540 0.256249709187235 3570 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3082 9117008 49.47 µM -0.65524384887758 0.247544105350206 no 2541 0.256155383375933 3588 41448529 SGTC_2819 7996655 46.38 µM -0.655446146598173 0.247477773238082 no 2542 0.256090274335504 3491 6456960 SGTC_3313 9133968 57.047 µM -0.656554614201066 0.247114482554954 no 2543 0.255733669954571 3595 1494643 SGTC_2393 9031399 185.94 µM -0.657656628370789 0.246753589891808 no 2544 0.255379398873048 3650 1526623 YDL150W RPC53 SGTC_1578 josamycin 24.2 µM -0.6587167358116 0.246406687518477 no 2545 0.255038842004237 3542 5282165 A P450 substrate. SGTC_1266 0828-0227 32.9 µM -0.65883936689797 0.246366575425997 no 2546 0.254999462410502 3576 3913820 SGTC_3003 9075612 71.4286 µM -0.658970017355988 0.246323844083063 no 2547 0.254957511116976 3604 6501993 SGTC_3045 9092950 49.47 µM -0.660445838455104 0.245841428984845 no 2548 0.254483882298414 3641 44120432 SGTC_3207 9114163 49.47 µM -0.662111612061247 0.245297532195264 no 2549 0.253949847208464 3663 849233 SGTC_1048 3161-0300 24.5 µM -0.662310647093652 0.245232587952799 no 2550 0.253886077357243 3625 2165101 SGTC_3073 9114972 49.47 µM -0.662373542392053 0.245212067420121 no 2551 0.253865927758893 3548 41905075 SGTC_619 1652-1634 108 µM -0.66261198976687 0.245134278780272 no 2552 0.253789544635923 3562 5400454 SGTC_3029 9088683 49.47 µM -0.663248293094033 0.244926762647454 no 2553 0.253585773261803 3619 25236615 SGTC_626 0214-0009 33 µM -0.663282344950868 0.244915660059449 no 2554 0.253574870833018 3639 3437874 SGTC_462 ag-879 158 µM -0.665152774577016 0.244306223783142 no 2555 0.252976391297147 3626 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_414 piperonyl butoxide 100 µM -0.66744193959123 0.243561466026769 no 2556 0.252244942172417 3599 5794 A potent inhibitor of cytochrome P450. SGTC_3054 9094397 49.47 µM -0.667971171153852 0.243389460322665 no 2557 0.252075997460853 3612 2598354 SGTC_2308 7584454 197.62 µM -0.668339582487621 0.243269761608302 no 2558 0.251958426070256 3674 893577 SGTC_1459 k035-0031 35.7 µM -0.668520138670189 0.243211109607777 no 2559 0.251900815606312 3527 3877128 YMR208W ERG12 SGTC_1973 st070275 50.2 µM -0.669244558626354 0.24297586539178 no 2560 0.251669743241114 3572 17118334 SGTC_2976 9009005 19.48 µM -0.669354802417044 0.242940076214064 no 2561 0.251634587967883 3647 2993148 SGTC_2252 omeprazole 400 µM -0.670893893452652 0.242440728779709 no 2562 0.251144063394641 3579 4594 A proton pump inhibitor. SGTC_716 1683-5115 658 µM -0.670993044907097 0.242408578851326 no 2563 0.251112480128711 3660 723597 SGTC_433 pimozide 108 µM -0.671277897675748 0.242316227993464 no 2564 0.251021756077056 3578 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2175 5807670 165.306 µM -0.67220637524139 0.24201534278349 no 2565 0.25072616147832 3591 241186 SGTC_2948 9070189 9.45 µM -0.672698503656379 0.241855944382186 no 2566 0.250569559877146 3546 6473636 YDL196W YDL196W SGTC_2581 avocatin a 64 µM -0.67316609937976 0.24170454481006 no 2567 0.250420812917589 3640 6710728 A skin care supplement. SGTC_1896 st058441 89 µM -0.673623517490687 0.241556490367107 no 2568 0.250275348856365 3586 688759 SGTC_351 caspofungin 25 nM -0.6738126578479 0.24149528490716 no 2569 0.250215213208672 3680 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1487 3970-0795 2.82 µM -0.674046526806059 0.24141961700433 no 2570 0.250140867060232 3671 3765103 SGTC_2357 9067248 200 µM -0.674428999461215 0.241295896388211 no 2571 0.250019305555829 3625 9150235 SGTC_1146 3579-1023 7 µM -0.674490759476595 0.241275921754335 no 2572 0.249999679274407 3669 X1146 SGTC_3043 9092303 49.47 µM -0.674809455142598 0.241172862403211 no 2573 0.249898416212598 3597 25236084 SGTC_1254 0550-0035 264 µM -0.678451299561549 0.239996868753186 no 2574 0.248742796098502 3671 15121435 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.680409536015758 0.239365826590167 no 2575 0.248122592311097 3624 15053 SGTC_2199 6590217 200 µM -0.681687396327759 0.238954524962954 no 2576 0.247718319368389 3601 703109 SGTC_1425 4048-4433 7.33 µM -0.68265756613028 0.238642517142952 no 2577 0.247411624631943 3700 23734946 SGTC_635 k038-0028 24.7 µM -0.683673579521725 0.23831600510763 no 2578 0.247090655276547 3676 4035102 SGTC_2827 7993847 71.43 µM -0.683810413270983 0.23827205011309 no 2579 0.24704744507616 3604 2985692 SGTC_921 1561-0023 372 µM -0.683827893356231 0.23826643531936 no 2580 0.24704192539887 3654 24050882 SGTC_2980 9014342 25.29 µM -0.684083126936829 0.238184459769831 no 2581 0.246961337941339 3654 2996599 SGTC_1239 0337-0584 35.4 µM -0.684132771205815 0.238168516891199 no 2582 0.246945664892868 3697 914301 YML130C ERO1 SGTC_357 1325-0123 420 µM -0.684301780972165 0.238114245076823 no 2583 0.24689231129961 3624 1098503 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.685006913982394 0.237887888414862 no 2584 0.246669779030669 3663 3256 An antibiotic and ribosome inhibitor. SGTC_3335 9143315 29.6265 µM -0.686412683092176 0.23743697095978 no 2585 0.246226454400855 3635 4899691 SGTC_259 usnic acid 108.925 µM -0.688237386778849 0.236852375653781 no 2586 0.245651651942464 3733 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3149 9097855 49.47 µM -0.68833498781819 0.236821128720246 no 2587 0.245620926819082 3650 25236625 YMR079W SEC14 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.689513454728418 0.236444021986082 no 2588 0.245250104586922 3652 7104 SGTC_95 0471-0001 561.058 µM -0.690276496572691 0.236200026727028 no 2589 0.245010162692628 3595 4015405 SGTC_2359 9039622 200 µM -0.690744654066284 0.236050394290258 no 2590 0.244863011026277 3636 6463596 SGTC_2999 9069765 71.4286 µM -0.690775801189213 0.236040440904271 no 2591 0.244853222523608 3677 2097066 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.690953299693595 0.23598372383151 no 2592 0.244797444679283 3662 688669 SGTC_3236 9132701 49.47 µM -0.690975865758819 0.235976513710789 no 2593 0.244790353918215 3639 24282524 SGTC_2001 4023502 57.655 µM -0.69273362122395 0.2354152635463 no 2594 0.244238367811552 3662 108941 YCR052W RSC6 SGTC_3055 9094636 49.47 µM -0.694488727968884 0.23485559495792 no 2595 0.243687883681885 3692 25236176 SGTC_584 0986-0246 15.4 µM -0.694532739264489 0.234841570090202 no 2596 0.24367408828184 3753 53315 YDR232W HEM1 SGTC_594 1487-1584 10.8 µM -0.694924593038354 0.234716720345492 no 2597 0.243551279779816 3643 5013332 SGTC_1953 st076800 12.1 µM -0.694999321202687 0.234692915140873 no 2598 0.243527863477513 3660 297591 SGTC_1018 4259-0013 28.1 µM -0.695959660785138 0.23438711077012 no 2599 0.243227046347273 3694 6801262 SGTC_3181 9108277 49.47 µM -0.696300961150281 0.234278482404052 no 2600 0.243120185693436 3638 17097298 SGTC_1415 3966-0071 78.1 µM -0.69636455228783 0.234258245830126 no 2601 0.24310027820575 3659 2893185 SGTC_2426 5582046 32.21 µM -0.696788565851738 0.234123336957946 no 2602 0.242967561416101 3668 2251934 SGTC_182 3448-4371 550.524 µM -0.69822276526921 0.233667335145427 no 2603 0.242518945804893 3686 3491403 SGTC_3312 9133330 71.43 µM -0.699165600395215 0.233367830414433 no 2604 0.242224272855634 3690 17617324 SGTC_2300 7976697 71.57 µM -0.699762935033491 0.233178189007416 no 2605 0.242037682832988 3605 2236109 SGTC_3071 9117417 49.47 µM -0.700335573091717 0.232996468597315 no 2606 0.241858880513199 3611 45595590 YGL055W OLE1 SGTC_2740 felodipine 17.08 µM -0.700451435442197 0.232959710519476 no 2607 0.24182271200544 3613 3333 L-type calcium channel blocker SGTC_2932 9016711 44.54 µM -0.700534130030912 0.232933477097882 no 2608 0.241796899203592 3654 7117328 SGTC_1548 st061468 90.8 µM -0.701897280829724 0.232501277730608 no 2609 0.24137161240665 3672 390799 SGTC_599 1935-0052 86.5 µM -0.703245284968344 0.232074319638989 no 2610 0.240951451148175 3662 9557311 SGTC_2372 9071633 200 µM -0.704155430460011 0.231786293069014 no 2611 0.240667991771618 3714 21321366 SGTC_334 1502-1024 68.5 µM -0.706739653181518 0.230969570932398 no 2612 0.239864141306192 3712 3296216 SGTC_1350 1495-0454 146 µM -0.708670743878312 0.230360316056306 no 2613 0.239264412048996 3698 1069057 SGTC_3212 9128307 49.47 µM -0.709887704556063 0.22997682967318 no 2614 0.238886887835313 3669 27243542 SGTC_1395 3486-0190 4.35 µM -0.710623877787684 0.229745021688205 no 2615 0.238658671214031 3702 6748079 SGTC_117 lucigenin 22.078 µM -0.711649828633572 0.229422186188605 no 2616 0.238340821475993 3677 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_419 nsc-638432 893 µM -0.713900077820492 0.22871499244665 no 2617 0.237644484617849 3693 368090 SGTC_2342 7990637 118.86 µM -0.718639223768367 0.227229615124088 no 2618 0.236181619613704 3765 2033102 YER133W GLC7 SGTC_1221 2958-7315 257 µM -0.719470607265571 0.226969598586782 no 2619 0.235925503056013 3714 4562705 SGTC_2238 6671620 73.2395 µM -0.720847946277465 0.226539203053462 no 2620 0.235501536149625 3678 729941 SGTC_975 1335-0046 28.5 µM -0.721704682935528 0.226271719702268 no 2621 0.235238031166519 3703 16486740 SGTC_1238 0333-0287 48.8 µM -0.721785138793341 0.226246609596478 no 2622 0.235213293864878 3720 7226 SGTC_1060 3448-7350 82 µM -0.722354766477633 0.226068875018496 no 2623 0.235038194797329 3663 570178 SGTC_2785 7756463 72.73 µM -0.72277490547544 0.225937834314921 no 2624 0.234909093532398 3700 2201551 SGTC_321 4534-3890 65.3 µM -0.725013682013785 0.225240287970867 no 2625 0.234221818396811 3738 699746 SGTC_1011 4112-3381 17.4 µM -0.727676311709081 0.224412269929258 no 2626 0.233405877174663 3764 2877139 SGTC_136 0097-0015 404.482 µM -0.72798872035748 0.224315231225215 no 2627 0.233310245558298 3725 4861337 SGTC_119 0121-0043 24.815 µM -0.730627001537997 0.223496693038296 no 2628 0.232503507305945 3802 1092378 SGTC_2844 9010103 25.97 µM -0.731190406330411 0.22332211467588 no 2629 0.232331429616865 3722 2480525 SGTC_2839 9003951 25.97 µM -0.7313039796954 0.223286931880645 no 2630 0.232296750098856 3705 2990634 SGTC_2848 9016370 25.97 µM -0.732705184548833 0.222853125797051 no 2631 0.231869130578199 3717 7894410 SGTC_2129 girgensonine 121.053 µM -0.732732540114038 0.222844661431119 no 2632 0.231860786575925 3784 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_579 4491-1009 110 µM -0.733022872310283 0.222754838058488 no 2633 0.231772239674545 3857 1271041 SGTC_282 k297-0036 65.7 µM -0.733641398513824 0.222563546392059 no 2634 0.231583661430936 3735 5061378 SGTC_1941 st076221 61.8 µM -0.733825652553298 0.22250658023649 no 2635 0.231527502008377 3711 2828568 SGTC_750 4073-0104 132 µM -0.737320254001188 0.221427723393359 no 2636 0.230463809043194 3605 22330957 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.738689460157535 0.221005837552621 no 2637 0.230047793655325 3716 77254 SGTC_2731 amoxapine 43.43 µM -0.740144167834668 0.220558111071722 no 2638 0.229606260521887 3779 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1772 st048439 82.2 µM -0.740970666923609 0.220303964828332 no 2639 0.229355613008081 3755 2927068 YDL195W SEC31 SGTC_1472 k841-0093 193 µM -0.741041317130564 0.220282247872205 no 2640 0.229334194453882 3820 X1472 SGTC_1396 3511-0007 98.6 µM -0.742557898621222 0.219816366475564 no 2641 0.22887469297683 3709 X1396 SGTC_1257 0669-0121 16 µM -0.742630341286148 0.219794126845072 no 2642 0.228852756872617 3771 4307855 SGTC_2325 6158266 200 µM -0.743161934689496 0.219630969153657 no 2643 0.228691823081789 3773 3623240 SGTC_1379 2144-0755 36.5 µM -0.74375079827138 0.21945031520812 no 2644 0.228513625610787 3792 5392327 SGTC_2972 9093619 59.92 µM -0.744446961300346 0.219236853665799 no 2645 0.228303058639426 3770 25236256 SGTC_2257 7960413 200 µM -0.744681651794021 0.219164918415569 no 2646 0.228232096885106 3723 2974689 YIL048W NEO1 SGTC_7 0192-1582 4.227 µM -0.745182160349255 0.219011552305384 no 2647 0.228080802973144 3786 252616 SGTC_2077 5212015 200 µM -0.745527411334632 0.218905796289179 no 2648 0.227976473256911 3650 780900 SGTC_2855 9016525 58.44 µM -0.746304314680371 0.218667925567542 no 2649 0.22774180281225 3743 43811474 SGTC_1356 1502-0781 85.8 µM -0.74850244712763 0.217995712313453 no 2650 0.227078574785856 3728 567702 SGTC_3351 9150312 21.596 µM -0.749705578299594 0.217628286559807 no 2651 0.226716023560078 3717 4904905 SGTC_2131 toluylene red 5.2905 µM -0.751237335357423 0.217161018836836 no 2652 0.226254917316553 3770 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1717 st033143 58.0435 µM -0.751780295793137 0.216995526139726 no 2653 0.22609159671228 3743 674616 SGTC_478 N-arachidonylglycine 10 µM -0.753156338697043 0.216576439014177 no 2654 0.225677986362505 3697 5283389 SGTC_994 3910-0338 138 µM -0.755693505855091 0.215804949166416 no 2655 0.224916489299811 3852 3479481 SGTC_3155 9099265 49.47 µM -0.757430454531877 0.215277705732029 no 2656 0.224396008178623 3741 25236499 SGTC_809 3998-0021 90 µM -0.758440534923658 0.214971444157475 no 2657 0.22409364963488 3687 715485 SGTC_2856 9022925 19.48 µM -0.759327660307372 0.214702671997522 no 2658 0.223828287551577 3783 4944862 SGTC_2332 7982454 138.89 µM -0.759574510377995 0.214627918635358 no 2659 0.223754480104087 3738 2981748 SGTC_952 1185-0122 232 µM -0.761370462366501 0.214084507852994 no 2660 0.223217912413456 3728 678600 SGTC_1525 8-methoxypsoralen 92.5 µM -0.761478711927837 0.214051779810736 no 2661 0.223185594648419 3775 4114 Related to psoralen; DNA damaging agent. SGTC_890 0929-0006 47.2 µM -0.761965697791694 0.213904581112047 no 2662 0.223040238605712 3758 1378169 SGTC_863 0466-0191 129 µM -0.762100439198416 0.213863863935385 no 2663 0.223000030375613 3787 765160 YPR165W RHO1 SGTC_835 0312-0010 67.2 µM -0.763422152561743 0.213464697925131 no 2664 0.222605836359203 3741 1626196 SGTC_3320 9137005 35.139 µM -0.763533413613179 0.213431116192124 no 2665 0.222572671476745 3812 4908713 SGTC_1723 st034307 2.5525 µM -0.764886054125793 0.213023097365887 no 2666 0.222169699479913 3833 867466 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.765005300788871 0.212987148908665 no 2667 0.222134194084492 3751 2346 DNA damaging agent; causes G2/M arrest. SGTC_1957 st077035 62.4 µM -0.765122391236098 0.212951853915264 no 2668 0.222099333848433 3816 705593 SGTC_1500 4488-1866 171 µM -0.765605499481231 0.212806264960872 no 2669 0.221955535606866 3863 2900003 SGTC_2307 7538926 6.34 µM -0.765810307723928 0.212744561721824 no 2670 0.221894590028431 3801 96582 SGTC_2103 5378138 10 µM -0.766267950495124 0.212606723961805 no 2671 0.221758442046891 3804 244142 SGTC_1834 st055981 52.8 µM -0.766941755472829 0.212403875104418 no 2672 0.221558073044784 3828 471719 YDL150W RPC53 SGTC_420 mitomycin C 81.9 mM -0.7680689164973 0.21206479642499 no 2673 0.221223121256014 3765 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_954 1189-0853 2.85 µM -0.769311606317973 0.211691330857289 no 2674 0.220854174404083 3756 2828194 SGTC_942 3253-1115 227 µM -0.770324867418988 0.211387100598236 no 2675 0.220553604422172 3831 46497897 SGTC_1290 0986-0249 10.2 µM -0.770499636987706 0.211334652180209 no 2676 0.220501785141012 3721 53329 SGTC_649 1123-0311 367 µM -0.770731802564875 0.211264990987137 no 2677 0.220432958700292 3757 693629 YIL048W NEO1 SGTC_1486 3970-0793 4.53 µM -0.771516104544257 0.211029760984155 no 2678 0.220200540228516 3841 2844330 SGTC_933 2914-0560 114 µM -0.772678487574876 0.210681418406926 no 2679 0.219856340587665 3808 463887 SGTC_252 miconazole 1.30953 nM -0.773481486699437 0.210440973021382 no 2680 0.219618740549892 3741 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1451 4152-0210 104 µM -0.77357035152963 0.210414373756769 no 2681 0.219592455331411 3765 659563 SGTC_1434 4073-0095 163 µM -0.774372352857877 0.21017440581804 no 2682 0.219355314096135 3758 24133745 SGTC_574 1315-0397 40 µM -0.774691726201988 0.210078890442628 no 2683 0.219260920587991 3809 6794277 SGTC_832 4083-0019 164 µM -0.774977785418868 0.209993360018236 no 2684 0.219176393178246 3868 1990758 SGTC_1781 st038725 66.3 µM -0.776953329589951 0.209403240010371 no 2685 0.218593152867684 3805 4270275 YIL048W NEO1 SGTC_1093 fluphenazine 7.97 µM -0.779201360034224 0.208732913315941 no 2686 0.21793055454384 3826 6602611 An atypical antipsychotic. SGTC_214 4373-3496 70 µM -0.779398721294474 0.208674123794483 no 2687 0.217872438425631 3873 3779166 SGTC_2842 9000675 19.48 µM -0.779644995130218 0.208600777996046 no 2688 0.217799931769065 3814 2989072 SGTC_2870 9038528 12.99 µM -0.780587551022597 0.208320204419384 no 2689 0.217522557991976 3802 6463316 SGTC_3089 9117425 49.47 µM -0.782185823941489 0.207844950620793 no 2690 0.217052687199543 3737 9401657 SGTC_492 tmb-8 126 µM -0.782493421731469 0.207753558532556 no 2691 0.216962324923904 3697 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3086 9117350 49.47 µM -0.784523377613238 0.207151022549103 no 2692 0.216366535056753 3721 2679265 SGTC_2708 st078559 56 µM -0.785068201647973 0.206989482792619 no 2693 0.216206791123374 3769 17250902 SGTC_964 1287-0107 19.4 µM -0.785108444636353 0.206977553745698 no 2694 0.216194994475459 3827 51516812 YPR165W RHO1 SGTC_1005 4092-0690 4.4 µM -0.785148464391634 0.206965691274203 no 2695 0.216183263634701 3833 1529343 SGTC_2978 9011784 42.97 µM -0.787651889508448 0.206224437579145 no 2696 0.215450177013877 3844 2994934 SGTC_2953 9074162 66.49 µM -0.789628795626386 0.205640197549342 no 2697 0.214872293135988 3751 16451992 SGTC_791 1348-1292 225 µM -0.790424445106569 0.205405334815271 no 2698 0.214639965368905 3792 5437054 SGTC_2468 5987765 72.9 µM -0.790466189413707 0.205393016977347 no 2699 0.214627780162174 3856 26772094 SGTC_986 1493-0483 84 µM -0.79219813778283 0.204882343442603 no 2700 0.214122577125038 3748 40079 SGTC_1872 amphotericin b 148 nM -0.792240140097192 0.204869968236648 no 2701 0.21411033380353 3846 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_301 4119-0100 24.5 µM -0.793462981361857 0.204509875523593 no 2702 0.213754064476838 3843 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3213 9129884 49.47 µM -0.795092844080382 0.20403051235669 no 2703 0.213279748464092 3829 17190742 SGTC_1220 1838-0075 193 µM -0.796657891945925 0.203570842657793 no 2704 0.212824872708879 3758 5529645 SGTC_44 0929-0055 61.211 µM -0.797970432991821 0.20318581327023 no 2705 0.212443824168017 3785 1379590 SGTC_1510 1123-0200 71.5 µM -0.798846000994165 0.202929210296045 no 2706 0.212189856635014 3868 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_997 3996-0078 137 µM -0.799455202588101 0.2027507856435 no 2707 0.212013256181448 3863 735687 SGTC_265 mycophenolic acid 32.932 µM -0.799652989548213 0.202692877412995 no 2708 0.211955938532701 3893 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_103 0844-0104 51.839 µM -0.799888964190236 0.202623801493196 no 2709 0.211887566148153 3821 5375804 SGTC_3254 9136651 49.47 µM -0.799919502698461 0.202614863105312 no 2710 0.211878718722523 3824 16454030 SGTC_1157 4092-0394 27.6 µM -0.800579223115416 0.202421825526491 no 2711 0.211687641419611 3941 3659885 SGTC_1250 0485-0349 40.2 µM -0.800733126834272 0.202376808333733 no 2712 0.211643080220029 3836 6842794 YDL195W SEC31 SGTC_1952 st077036 64.1 µM -0.804182228934218 0.201369509375436 no 2713 0.210645870256434 3832 2937007 SGTC_2768 sulfasalazine 50.2 µM -0.805283670201145 0.20104847120578 no 2714 0.210328001452072 3825 5384001 An antioxidant and salicylic acid derivative. SGTC_2089 5281248 129.67 µM -0.806077941414491 0.200817154823329 no 2715 0.21009895481032 3833 2737878 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.80620755947659 0.200779421193303 no 2716 0.210061590329526 3837 688662 SGTC_1304 1165-0502 251 µM -0.806553353261009 0.200678776609697 no 2717 0.209961928839539 3854 767425 SGTC_2534 helenine 20.12 µM -0.808532447489814 0.200103336716992 no 2718 0.209392067423866 3834 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2989 9073649 71.4286 µM -0.809471496223438 0.199830646952545 no 2719 0.20912199592455 3772 21367202 SGTC_1554 st069299 38.7 µM -0.811140905764148 0.19934642039613 no 2720 0.208642378558623 3788 24207999 SGTC_2448 5185112 27.17 µM -0.812325966240608 0.199003112606211 no 2721 0.208302307378661 3864 5718189 SGTC_2828 7998861 71.43 µM -0.812559320527805 0.198935552710574 no 2722 0.208235381361605 3757 2988188 SGTC_2192 5915882 198.485 µM -0.813514247701432 0.198659229677424 no 2723 0.207961640437303 3822 2876149 SGTC_2544 sphondin 68.51 µM -0.814601272002261 0.198344964147755 no 2724 0.20765029106205 3817 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2775 cyproheptadine 69.59 µM -0.815184462294529 0.198176483911288 no 2725 0.207483365194914 3845 2913 A selective serotonin reuptake inhibitor. SGTC_96 0929-0093 37.281 µM -0.818018810800657 0.197358888387101 no 2726 0.206673223126989 3836 6991579 SGTC_660 4031-1742 102 µM -0.81830256189798 0.197277150101034 no 2727 0.206592221807271 3785 6738706 SGTC_3020 9089140 49.47 µM -0.818953169840142 0.197089811133113 no 2728 0.206406566291458 3926 17217859 SGTC_1361 1608-0041 5.61 µM -0.819620533164946 0.196897759442361 no 2729 0.206216232257765 3817 X1361 SGTC_1968 st069590 43.6 µM -0.820034406619349 0.196778713199333 no 2730 0.206098246586673 3861 6384066 SGTC_627 1391-0720 175 µM -0.820405069385399 0.19667213305359 no 2731 0.205992613259632 3861 997839 SGTC_2986 9022445 71.43 µM -0.820717077337535 0.196582445587515 no 2732 0.205903720570424 3822 6459286 SGTC_539 4859-0462 2.54 µM -0.82099285827734 0.196503192300933 no 2733 0.205825168094788 3918 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1108 betulinic acid 729.144 nM -0.821992900121496 0.196215965033602 no 2734 0.205540468861787 3866 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1033 k072-0102 21.3 µM -0.82205171429876 0.196199080634787 no 2735 0.205523732493961 3808 5965931 SGTC_1499 4480-0877 67.3 µM -0.822344445212346 0.196115056426164 no 2736 0.205440443998674 3797 2861909 SGTC_1996 st072960 66.8 µM -0.82261534707629 0.196037317379569 no 2737 0.205363384217026 3833 1719405 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.82277091893578 0.195992682327761 no 2738 0.205319138560249 3922 688664 SGTC_2666 tannic acid 100 µM -0.824786597123982 0.195414922598289 no 2739 0.20474637861863 3874 16134267 A thiamine antagonist. SGTC_5 0352-0601 109.883 µM -0.825090045050814 0.195328034114305 no 2740 0.204660235518446 3781 762456 SGTC_507 nimesulide 162 µM -0.825285122402463 0.195272188573496 no 2741 0.204604868153092 3903 4495 A COX2 inhibitor. SGTC_1422 4031-0024 15.5 µM -0.832820326296665 0.193122488237693 no 2742 0.202473034651051 3827 782427 SGTC_77 0828-0286 12.516 µM -0.833352635566527 0.1929711753356 no 2743 0.202322939478648 3828 745345 SGTC_1071 trifluoperazine 6.31 µM -0.834908328745732 0.192529373046995 no 2744 0.201884662489778 3980 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3324 9138759 60.749 µM -0.836459996940389 0.192089330285399 no 2745 0.201448086123086 3935 45595710 SGTC_2721 ifenprodil 61.44 µM -0.836635655438111 0.192039553512201 no 2746 0.201398698636214 3864 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1034 k072-0165 12.7 µM -0.837242177700217 0.19186774252155 no 2747 0.201228226898676 3911 5835461 SGTC_2017 5132927 60.65 µM -0.83847765210114 0.191518057957829 no 2748 0.200881246900914 3906 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1938 st074717 56.4 µM -0.838594391372736 0.191485036664372 no 2749 0.200848479533083 3725 17250979 SGTC_2470 5664817 21.68 µM -0.839180688815969 0.1913192472039 no 2750 0.200683961110849 3908 2859561 SGTC_3031 9088762 49.47 µM -0.839832866604837 0.191134931916252 no 2751 0.200501051362326 3860 205253 SGTC_2955 9076254 12.21 µM -0.840436378082361 0.190964467491611 no 2752 0.200331879788591 3841 16459619 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.840969035451957 0.190814093614965 no 2753 0.200182640746996 3896 6708760 SGTC_3068 9116768 49.47 µM -0.841945457005871 0.190538629922053 no 2754 0.199909242169917 3845 41904888 SGTC_2106 5357045 167.29 µM -0.842508184389694 0.190379986739318 no 2755 0.199751780235232 3926 668842 SGTC_3047 9092122 49.47 µM -0.843670420542891 0.190052587920796 no 2756 0.199426800505198 3879 17173831 SGTC_1213 1315-0166 115 µM -0.844678278428537 0.189768957376 no 2757 0.199145245243261 3986 768401 SGTC_1398 3558-0053 112 µM -0.844900791315226 0.189706373078098 no 2758 0.199083116309363 3795 4532369 SGTC_1690 st023502 41.2 µM -0.845269039263254 0.189602827018162 no 2759 0.198980321620055 3866 24207482 SGTC_2587 piperic acid 92.2 µM -0.845873679707382 0.189432886198188 no 2760 0.198811608463465 3916 5370536 SGTC_1903 st060211 78.3 µM -0.846001786319415 0.189396892469759 no 2761 0.198775873879217 3953 688960 SGTC_823 0417-1665 178 µM -0.846902424796162 0.189143961631091 no 2762 0.198524755413156 3915 3429856 SGTC_3337 9144342 33.5465 µM -0.849600243205311 0.188387565270825 no 2763 0.197773688348915 3912 17682949 SGTC_294 k038-0071 157 µM -0.849807656294273 0.188329489509244 no 2764 0.197716016136587 3900 24152826 SGTC_1056 3448-1962 115 µM -0.851247886968422 0.18792652892606 no 2765 0.197315833406564 3901 715507 SGTC_1432 4049-0298 68.4 µM -0.851847215183068 0.187759000506873 no 2766 0.197149448431121 3917 741646 SGTC_595 3909-8003 73.7 µM -0.852760062358024 0.187504012383245 no 2767 0.196896187782585 3989 699517 SGTC_1810 st050138 53 µM -0.855192832185716 0.186825505878615 no 2768 0.196222201844192 3860 3444541 SGTC_2770 toltrazuril 17.5 µM -0.856762220440202 0.186388606355852 no 2769 0.195788154397555 3824 68591 Kills coccidiodes. SGTC_3187 9109394 49.47 µM -0.857304581459258 0.186237766605921 no 2770 0.195638288600865 3920 17098090 SGTC_292 k038-0015 474 µM -0.857490575545596 0.18618605593589 no 2771 0.195586910550686 3894 46368540 SGTC_527 4476-4215 268 µM -0.858183089791977 0.185993599168309 no 2772 0.195395686026681 3899 4418754 SGTC_2157 5649910 96.377 µM -0.859398450907101 0.185656136235906 no 2773 0.195060362042063 3882 2858091 SGTC_612 0302-0167 22.4 µM -0.860063477413547 0.185471642732203 no 2774 0.194877026195901 3936 235821 SGTC_1796 st049173 110.4 µM -0.861043459347227 0.185199980899829 no 2775 0.194607053870045 3849 94134 SGTC_512 prima-1 270 µM -0.861567281274065 0.185054873068215 no 2776 0.19446284109901 3934 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1864 st057645 30.4 µM -0.866916841663589 0.183576997980239 no 2777 0.192993787501912 3964 688666 SGTC_3157 9099274 49.47 µM -0.868112010228778 0.183247827422884 no 2778 0.19266650840128 3897 17217662 SGTC_3328 9140624 29.0385 µM -0.868195432270782 0.183224865268425 no 2779 0.192643677188258 3968 4904392 SGTC_1389 3405-0187 19 µM -0.868407822979394 0.183166412222176 no 2780 0.192585556879465 3893 799890 SGTC_1043 0916-0009 19.3 µM -0.868789270645011 0.183061461422849 no 2781 0.192481201372272 3934 3101130 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.869808181088631 0.182781304302605 no 2782 0.192202619926328 3988 5393153 SGTC_3027 9089541 49.47 µM -0.870990781119324 0.182456475291451 no 2783 0.191879593371266 3947 9943819 SGTC_651 3253-0966 34.4 µM -0.872030486629561 0.18217119371059 no 2784 0.191595873083019 3961 781462 SGTC_1800 st050079 29.0735 µM -0.872927495262836 0.181925290450487 no 2785 0.19135129927159 3837 3645560 SGTC_3217 9129673 49.47 µM -0.87325874277661 0.181834535755923 no 2786 0.191261031405472 3943 17248312 SGTC_1477 0139-0234 16 µM -0.876070770449325 0.181065241668775 no 2787 0.190495780879635 3947 620880 SGTC_874 0599-0792 117 µM -0.87820527361671 0.180482663251768 no 2788 0.189916165318432 3926 765305 SGTC_2186 6124449 200 µM -0.87989792571897 0.180021517885078 no 2789 0.189457304263636 3949 3834182 YLR033W RSC58 SGTC_2048 5246248 200 µM -0.880611593148588 0.179827308575124 no 2790 0.189264040808567 3937 677046 SGTC_1641 st009299 47.1 µM -0.880753666364917 0.179788662104675 no 2791 0.189225581411925 3866 4046054 SGTC_3244 9134489 49.47 µM -0.881943088601196 0.179465322572908 no 2792 0.188903792130806 3963 16584271 SGTC_1516 st013856 110 µM -0.882089695210439 0.179425493491208 no 2793 0.188864152163656 4006 5281404 A mutagen and neurotoxin. SGTC_199 4063-0024 41.6 µM -0.882912631003236 0.179202027074896 no 2794 0.188641739280023 3955 306215 SGTC_235 0330-0087 5 mM -0.883416183741017 0.179065374796318 no 2795 0.188505724952682 3958 46494818 YHR062C RPP1 SGTC_2900 5328528 85.29 µM -0.886516197854588 0.178225549238271 no 2796 0.187669714811367 3972 795359 SGTC_1429 4049-0205 9.46 µM -0.889865283799858 0.177321042099145 no 2797 0.186769113460784 3971 22774478 SGTC_573 3702-0553 84.7 µM -0.890558848048675 0.177134090081678 no 2798 0.186582942279262 3911 1222756 SGTC_2709 st078560 56 µM -0.890726335045245 0.177088962204111 no 2799 0.186538001524143 3935 17250903 SGTC_789 1309-1135 70.6 µM -0.891978344798459 0.176751849455859 no 2800 0.18620226983452 3941 3092424 SGTC_2526 patulin 37.61 µM -0.893331215138147 0.176388035620348 no 2801 0.185839913178267 4017 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1479 0549-0158 134 µM -0.893369875494302 0.176377646046558 no 2802 0.185829564709593 3991 5440202 SGTC_1076 itraconazole 331 nM -0.893812481438976 0.176258727834129 no 2803 0.185711114970631 3953 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_765 1319-0117 244 µM -0.894417185480289 0.176096339563557 no 2804 0.185549360439452 3914 3487746 YGL099W LSG1 SGTC_202 3594-0513 34.79 µM -0.895584547464469 0.175783122146242 no 2805 0.185237345850017 3959 708429 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.896136220811037 0.175635224350089 no 2806 0.185090007055732 3885 756377 SGTC_1686 st019653 115.5 µM -0.896553817248599 0.175523323605283 no 2807 0.184978525431237 3910 97252 SGTC_713 1488-1073 324 µM -0.8990148840927 0.17486476484216 no 2808 0.184322366351552 3913 3312542 SGTC_2237 6667747 47.222 µM -0.899190530704181 0.174817823460819 no 2809 0.184275591639574 3958 729940 YDL015C TSC13 SGTC_107 0358-0022 2.6945 µM -0.900554281869396 0.174453634490522 no 2810 0.183912675905484 4002 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.906906987519896 0.172763505426639 no 2811 0.182227992868621 3958 2724278 An inhibitor of dopamine biosynthesis. SGTC_2865 9030313 51.95 µM -0.906976990449971 0.172744939566637 no 2812 0.182209482580717 3923 42562754 SGTC_1265 0819-1001 68.8 µM -0.908039197390963 0.17246338192226 no 2813 0.181928756320739 3940 3106768 SGTC_3346 9158254 43.5805 µM -0.909831266856526 0.171989024550057 no 2814 0.181455751219883 3996 17639500 SGTC_311 1315-0136 58 µM -0.91080224870864 0.171732355757225 no 2815 0.181199788722657 4039 6759207 SGTC_1485 3909-9022 254 µM -0.910903752531339 0.171705538426627 no 2816 0.181173044156131 4011 714516 SGTC_2123 5259487 200 µM -0.912803579546754 0.171204097397334 no 2817 0.180672927689876 4004 2173474 SGTC_2607 solasodine 47.35 µM -0.913786197938133 0.17094511251988 no 2818 0.180414600096865 3991 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_966 1300-0360 30.2 µM -0.913815747325276 0.170937328187788 no 2819 0.180406835237368 3967 70588 SGTC_2745 rifampicin 24.3 µM -0.913988453829806 0.17089183584876 no 2820 0.18036145636683 3982 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2941 9056145 11.23 µM -0.914909090841552 0.1706494630795 no 2821 0.180119678592371 3846 2119517 SGTC_2349 9023730 187.07 µM -0.914973138864793 0.170632609579591 no 2822 0.180102865867878 4016 4126287 SGTC_2174 5790901 200 µM -0.916394027530111 0.170258993142412 no 2823 0.179730133363311 4012 786020 SGTC_2460 5552655 174.22 µM -0.917388256166981 0.169997876998584 no 2824 0.179469612232461 4005 5401989 SGTC_1569 carminic acid 40.6 µM -0.919340943336699 0.169485786681748 no 2825 0.178958634296268 4080 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2519 cryptotanshinone 88.04 µM -0.919834752367814 0.169356442713552 no 2826 0.178829559838994 3980 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2667 digitoxin 100 µM -0.92285842436893 0.168565830977052 no 2827 0.178040494675468 3931 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2121 5257820 149.641 µM -0.92424700941095 0.168203548350853 no 2828 0.177678862647752 4053 791256 SGTC_2909 7941780 10.49 µM -0.925688330796929 0.167828037003032 no 2829 0.177303986964425 3961 1243215 SGTC_1713 st033146 12.748 µM -0.925800459451552 0.167798846467223 no 2830 0.177274844189073 3988 674619 SGTC_401 neomycin 50 µM -0.92925813408675 0.166900312345846 no 2831 0.176377663148737 3987 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3286 9117135 37.221 µM -0.930062173130909 0.166691815037054 no 2832 0.176169447296464 3975 3438150 SGTC_2736 butenafine 14.65 µM -0.930470216598221 0.166586068619181 no 2833 0.17606383893217 3955 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2176 5809774 33.9695 µM -0.930817578274852 0.166496082303975 no 2834 0.175973967603393 3982 2870539 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.931128638451877 0.166415526766707 no 2835 0.175893513056449 3831 6708630 An antioxidant. SGTC_3336 9143619 71.43 µM -0.931214493555685 0.166393297224374 no 2836 0.175871311059001 4036 45595730 SGTC_2379 9035213 200 µM -0.931295835245735 0.166372238060756 no 2837 0.175850277860845 3973 646551 SGTC_1039 k821-0043 94 µM -0.935939218228547 0.165172931283971 no 2838 0.174652241680249 4043 15992768 SGTC_1045 1348-1485 165 µM -0.937467351411767 0.164779467369831 no 2839 0.174259105109137 4019 6810614 SGTC_1222 0366-0074 1.18 µM -0.938591434764143 0.164490426148402 no 2840 0.173970276035065 4037 286520 SGTC_1622 st003707 19.4 µM -0.940616408397424 0.163970564201996 no 2841 0.173450735081073 4041 10140899 SGTC_2641 levomentholum 100 µM -0.941625737916323 0.163711842316956 no 2842 0.173192143846131 3999 16666 SGTC_3142 9086498 49.47 µM -0.942372533296871 0.163520586592 no 2843 0.173000972236496 3950 25236367 SGTC_812 4251-0442 148 µM -0.942765246215883 0.163420070299617 no 2844 0.172900495897282 4040 5723007 SGTC_693 4161-2696 114 µM -0.943562592086485 0.163216110229976 no 2845 0.172696607876591 4058 805759 SGTC_1126 isoteolin 1.0172 µM -0.944199851657302 0.163053219015358 no 2846 0.172533765511666 3966 133323 SGTC_2831 7999036 19.48 µM -0.946674785767695 0.162421598566725 no 2847 0.171902261287743 4085 2988270 SGTC_1561 5-methoxyflavone 52.9 µM -0.946717930222696 0.162410601941232 no 2848 0.171891265652766 3939 94525 SGTC_2690 usnic acid 100 µM -0.946842199245945 0.162378931056105 no 2849 0.171859597422482 4046 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1454 4239-0054 42.6 µM -0.946852526763332 0.162376299192393 no 2850 0.171856965766165 4139 1340767 SGTC_2312 7706453 155.7 µM -0.947392760649227 0.162238664745994 no 2851 0.171719339336619 4038 976098 SGTC_2946 9065502 71.43 µM -0.947617477327436 0.162181436443798 no 2852 0.171662112732793 3834 16489101 SGTC_468 gf-109203x 121 µM -0.948061503494519 0.162068395532162 no 2853 0.171549072351468 3988 2396 A protein kinase C inhibitor. SGTC_3344 9148862 3.898 µM -0.949259408320957 0.16176368697399 no 2854 0.171244346519025 4082 4905352 SGTC_1150 3909-7983 10.9 µM -0.952208251033673 0.161015187746658 no 2855 0.170495688649523 4001 23965914 SGTC_3012 9080433 71.4286 µM -0.952645482759201 0.160904398762644 no 2856 0.170384862105061 4019 17688859 SGTC_1802 st050112 57.9 µM -0.954136957715761 0.160526852371723 no 2857 0.17000716035545 4027 4662563 SGTC_1922 5578187 25 µM -0.955486199037182 0.160185809440318 no 2858 0.169665940633962 4074 1350412 SGTC_2059 5238311 157 µM -0.958308873695032 0.159473865080568 no 2859 0.168953515261752 4029 703021 SGTC_3186 9110464 49.47 µM -0.958481074940451 0.159430499052836 no 2860 0.168910115027974 4052 17018021 SGTC_707 0865-0008 204 µM -0.960914406372454 0.15881853031317 no 2861 0.168297603276878 4049 723043 SGTC_1015 4130-4525 82 µM -0.961310015543398 0.15871918260566 no 2862 0.168198156767331 4038 1363237 SGTC_1001 4048-4355 44.4 µM -0.965509785474312 0.157667024248363 no 2863 0.167144768551476 4028 21824233 SGTC_1101 ebselen 5.29 µM -0.967173419475949 0.15725150792983 no 2864 0.166728673776375 4115 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1559 coumarin 343 70.1 µM -0.97030610790408 0.156471030413636 no 2865 0.165946966835533 4092 108770 A hepatotoxic, DNA x-linker. SGTC_614 0462-0418 107 µM -0.970848134532789 0.1563362492793 no 2866 0.165811954435994 3846 5188303 SGTC_1285 0929-0069 65.5 µM -0.97112958455776 0.156266293675825 no 2867 0.165741876591766 4074 1206237 SGTC_755 1995-0008 37.3 µM -0.973490732879942 0.155680232441727 no 2868 0.16515473189676 4024 689533 SGTC_1983 st071813 46.9 µM -0.974482596309004 0.155434474684583 no 2869 0.164908488151745 4109 11838595 SGTC_1439 4092-1168 46 µM -0.977299964819459 0.154737801563441 no 2870 0.164210335253114 4076 2886240 SGTC_3176 9106582 49.47 µM -0.978005066142037 0.154563768828935 no 2871 0.164035909222609 4000 17018027 SGTC_3264 9137442 49.47 µM -0.978306691041248 0.15448936145315 no 2872 0.163961330802177 4076 17015726 SGTC_1189 1431-2119 7.28 µM -0.978473771727948 0.1544481547717 no 2873 0.16392002865064 4065 3107275 SGTC_2052 5265182 7.135 µM -0.979507690951959 0.154193323536349 no 2874 0.163664595184043 4072 1239884 SGTC_2861 9024595 19.48 µM -0.980357433233675 0.153984094916057 no 2875 0.163454856864138 3965 16482810 SGTC_2894 9048625 32.47 µM -0.980656060991835 0.153910609636385 no 2876 0.163381189302045 4045 4092861 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.98342823398239 0.153229550775098 no 2877 0.162698360050591 4052 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2520 obtusaquinone 4.71 µM -0.987437843194716 0.152248020744029 no 2878 0.161714020043612 4131 5967872 SGTC_1961 st076550 68.7 µM -0.989310243661633 0.151791100415926 no 2879 0.161255686858815 4108 1579337 SGTC_1652 st011932 78 µM -0.990357451104371 0.151535948986731 no 2880 0.160999717366943 4026 1551076 SGTC_1606 st000094 49.2 µM -0.99244459374296 0.151028268927449 no 2881 0.160490347339929 4109 1242210 SGTC_2030 5175110 200 µM -0.992685343821027 0.150969781369995 no 2882 0.1604316597533 4118 2831986 SGTC_795 0685-0265 78 µM -0.993592799419339 0.15074946062214 no 2883 0.160210575581694 4102 302754 SGTC_1557 sumaresinolic acid 42.3 µM -0.993967049758723 0.150658658928612 no 2884 0.160119454687943 4045 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_662 k832-1615 104 µM -0.996244369252829 0.150106914369168 no 2885 0.159565713090139 4106 5878478 SGTC_3114 9122766 49.47 µM -0.997137551763014 0.149890884061295 no 2886 0.159348873910768 4085 17176985 SGTC_1937 st074714 47.2 µM -0.999018033076964 0.149436738057998 no 2887 0.158892977840488 4049 17250970 SGTC_1916 st067606 49.2 µM -1.00154939572879 0.148826852615174 no 2888 0.15828063596502 4041 19590279 SGTC_3288 9119690 36.221 µM -1.00303555287604 0.148469566318641 no 2889 0.157921853830466 4089 17595618 YKL019W RAM2 SGTC_2584 androsterone 48.74 µM -1.00340477168619 0.148380891635737 no 2890 0.157832801376231 4044 2754130 A steroid. SGTC_2918 7977171 22.06 µM -1.00538706098955 0.147905414143641 no 2891 0.15735525391059 4059 2236483 SGTC_2608 thymoquinone 42.66 µM -1.00538944777231 0.147904842258707 no 2892 0.157354679490892 4086 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2921 7974240 10.71 µM -1.01063776888738 0.146650898454451 no 2893 0.156094915989763 4191 2979074 YDR527W RBA50 SGTC_938 3126-1755 342 µM -1.01142264587682 0.146463988432794 no 2894 0.155907093477837 4103 1777771 SGTC_2208 7283366 200 µM -1.01192432534017 0.146344602669786 no 2895 0.155787118735174 4074 898663 SGTC_2815 7968870 71.43 µM -1.01232390266982 0.14624956113495 no 2896 0.155691604894219 4078 2977326 YHR190W ERG9 SGTC_1616 st002734 56.1 µM -1.01541720437485 0.145515206015584 no 2897 0.154953497716976 4053 4026101 SGTC_2254 7938975 95.19 µM -1.0155653144325 0.145480106752985 no 2898 0.154918214555149 4195 2969277 SGTC_1912 st060209 90.8 µM -1.0176476599887 0.144987233298496 no 2899 0.154422714578557 4118 688787 SGTC_98 0074-0023 107.663 µM -1.01955640875722 0.144536437240164 no 2900 0.15396944382739 4135 3563821 SGTC_1741 st038134 10.228 µM -1.02260434938329 0.143818553977204 no 2901 0.153247476164242 4179 1272587 SGTC_602 3130-1533 38.1 µM -1.02355604897103 0.143594893277465 no 2902 0.153022506774473 4153 720941 SGTC_1503 4585-0012 61.3 µM -1.02516181409816 0.143218051891442 no 2903 0.152643421378655 4172 2922052 SGTC_1427 4048-4900 550 nM -1.02711117335733 0.142761474147731 no 2904 0.152184058981045 4115 24132586 SGTC_688 0527-0193 473 µM -1.02992071167059 0.142105158561442 no 2905 0.151523613610487 4175 4007154 SGTC_1590 st077108 57.8 µM -1.03038492342734 0.141996914371681 no 2906 0.151414673871718 4146 5489485 SGTC_261 5-fluorouridine 15.376 µM -1.03084418916218 0.141889878430418 no 2907 0.151306946115263 4137 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2958 9077254 16.72 µM -1.03154571419391 0.141726487300488 no 2908 0.151142491187719 4203 16457351 SGTC_976 1348-1067 47.6 µM -1.03217701575403 0.141579560795599 no 2909 0.150994600088584 4126 5310671 YGL099W LSG1 SGTC_1985 st071382 65.5 µM -1.03347263735331 0.141278346523638 no 2910 0.15069138459014 4117 6123237 SGTC_2264 7948757 110.76 µM -1.03559774907975 0.14078522841279 no 2911 0.15019492126988 4088 2971411 SGTC_4 0960-0234 25.671 µM -1.03745429082266 0.14035538706806 no 2912 0.149762093823851 4138 6821112 SGTC_1696 st025591 34.7925 µM -1.03823630498769 0.140174595946131 no 2913 0.149580027162388 4144 2787147 SGTC_2295 7971645 200 µM -1.04202424072583 0.139301115805036 no 2914 0.148700220208294 4193 2978226 YKL099C UTP11 SGTC_9 0092-0002 10.449 µM -1.04394409461074 0.138859823694254 no 2915 0.148255627832111 4116 759368 SGTC_971 1315-0384 26.7 µM -1.04695266976893 0.138170197861152 no 2916 0.147560704018927 4180 6769120 SGTC_368 fentichlor 4.58 µM -1.04708224380171 0.138140549436529 no 2917 0.147530823967272 4190 7329 A pesticide. SGTC_1282 0886-0010 32.4 µM -1.04891340817404 0.13772201621025 no 2918 0.14710898693018 4199 2836211 YNL267W PIK1 SGTC_2988 9073640 71.4286 µM -1.04918289831163 0.137660494329607 no 2919 0.14704697404136 4210 9102229 SGTC_2914 7968218 45.32 µM -1.04974615179163 0.137531969816939 no 2920 0.14691741932252 4098 2977111 SGTC_1147 3809-1045 12.3 µM -1.05118118922204 0.137204889876202 no 2921 0.146587690447505 4127 325925 SGTC_1958 st076513 41.9 µM -1.05380660283185 0.136607870434159 no 2922 0.145985734945641 4099 732122 YGL099W LSG1 SGTC_2817 7995342 71.43 µM -1.05503694908538 0.136328701723888 no 2923 0.145704213184526 4143 18879975 SGTC_764 1951-2361 146 µM -1.05542108428798 0.136241620477859 no 2924 0.145616392074102 4143 5438930 SGTC_2555 cholic acid 100 µM -1.05570583138716 0.136177094514354 no 2925 0.145551316076848 4110 6708657 Influences liver metabolism. SGTC_3107 9121808 49.47 µM -1.0560739907861 0.13609369766489 no 2926 0.145467206056411 4039 662681 SGTC_3270 9137563 49.47 µM -1.05870145817607 0.135499528956836 no 2927 0.144867881793273 4137 17015724 SGTC_2866 9034245 58.44 µM -1.06095418049175 0.134991521446734 no 2928 0.144355362338176 4116 6462273 SGTC_2092 5303694 80.6725 µM -1.06153233158063 0.13486135451861 no 2929 0.144224023822637 4153 1963699 SGTC_2879 9041815 71.43 µM -1.06153588851407 0.134860553964961 no 2930 0.144223216043891 4164 4942971 SGTC_2564 betulinic acid 100 µM -1.06262867900919 0.134614755607542 no 2931 0.143975187986235 4219 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_128 0906-2981 13.371 µM -1.06408882115113 0.134286810017009 no 2932 0.143644232252936 4148 6740226 SGTC_822 1487-0950 154 µM -1.06843181774612 0.133314624781216 no 2933 0.142662885477885 4170 1958375 SGTC_946 3434-1334 87.4 µM -1.06961149865011 0.13305139011061 no 2934 0.142397108618359 4153 4047976 SGTC_2676 harmalol 100 µM -1.07079575386415 0.132787494803112 no 2935 0.142130638284694 4114 5459187 A monoamine oxidase inhibitor SGTC_2810 7959871 45.46 µM -1.0724511877237 0.132419208147815 no 2936 0.141758713569084 4134 2974535 SGTC_2688 kanamycin b 96.69 µM -1.07255328815884 0.132396516791709 no 2937 0.141735796364307 4223 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3274 9138298 49.47 µM -1.07350909515001 0.132184223009412 no 2938 0.141521380053245 4133 17015756 SGTC_286 k060-0067 22.9 µM -1.07518549195885 0.131812446437443 no 2939 0.141145844764901 4169 5985051 SGTC_2094 5332512 191.667 µM -1.07576442152834 0.131684224259211 no 2940 0.141016313911076 4197 755774 SGTC_2714 st079313 56.9 µM -1.07589192083221 0.131655997093732 no 2941 0.14098779779954 4149 2939799 SGTC_2446 5162541 200 µM -1.076520679623 0.131516856789269 no 2942 0.140847228701091 4135 1549321 SGTC_392 N-ethylmaleimide 8.33 µM -1.07689448025876 0.131434185223316 no 2943 0.140763704664217 4105 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_518 1021-0119 62.6 µM -1.07748248805041 0.131304211181699 no 2944 0.140632385050273 4144 1097762 SGTC_2241 6772625 37.8075 µM -1.08618035455197 0.129391985991907 no 2945 0.138699603549285 4016 2285411 SGTC_3226 9131256 49.47 µM -1.08890608058862 0.128796726620066 no 2946 0.138097652273135 4121 17178073 SGTC_1262 0737-0114 49.6 µM -1.09161194504545 0.12820768639253 no 2947 0.137501851770178 4258 765919 SGTC_2109 5483026 200 µM -1.09286487402497 0.127935570675125 no 2948 0.137226566369341 4188 759335 SGTC_1806 st050005 60.3 µM -1.09399071835889 0.12769139819418 no 2949 0.136979524494367 4232 5194765 SGTC_139 0099-0334 718.624 µM -1.09748930627894 0.126934694598208 no 2950 0.136213776446438 4226 97690 SGTC_2369 9071472 200 µM -1.09800651716956 0.126823093322322 no 2951 0.136100821737355 4244 17296037 SGTC_2644 guaiazulene 100 µM -1.09834679281165 0.126749707549044 no 2952 0.136026543241533 4203 3515 A coloring agent. SGTC_2863 9028737 58.44 µM -1.09965400534724 0.126468061692132 no 2953 0.135741450978815 4171 6460917 SGTC_1164 k060-0068 93.7 µM -1.10034854459102 0.126318597032852 no 2954 0.135590144304088 4188 5963676 SGTC_1292 0kpi-0043 232 µM -1.10664371692617 0.124969490810074 no 2955 0.134223999154157 4226 3333905 SGTC_3 0833-0587 95.581 µM -1.10752193687808 0.124782084241489 no 2956 0.134034166605976 4080 5382644 SGTC_374 0880-0231 82.3 µM -1.10933125283919 0.124396606997595 no 2957 0.133643653757771 4098 6833587 SGTC_3297 9117502 71.43 µM -1.11345351866592 0.123521464708785 no 2958 0.132756850310645 4218 7453720 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.11355892204226 0.123499144630272 no 2959 0.132734228645435 4204 75037 A free radical scavenger. SGTC_3183 9108214 49.47 µM -1.11381267586981 0.12344542164526 no 2960 0.132679778906639 4140 4974831 SGTC_1683 st010134 710 nM -1.11402962072752 0.123399504580188 no 2961 0.132633239727766 4197 3818134 SGTC_1935 st074532 41.6 µM -1.11457124131108 0.123284921099396 no 2962 0.132517099947214 4191 2829742 SGTC_934 2950-0684 338 µM -1.11509861047268 0.123173424258146 no 2963 0.132404083448619 4249 1121253 SGTC_1664 st014217 9.02 µM -1.11516445220352 0.123159508906705 no 2964 0.132389978070586 4258 3982782 SGTC_2390 9097792 176.6 µM -1.11601372428405 0.122980117857944 no 2965 0.132208129997723 4230 4497149 SGTC_3251 9135047 49.47 µM -1.11799543062198 0.122562236319365 no 2966 0.131784472460476 4240 17682963 SGTC_1017 4239-0030 168 µM -1.11807616125015 0.122545233832314 no 2967 0.131767233404932 4222 1149593 SGTC_3175 9106517 49.47 µM -1.11826161437666 0.122506182254623 no 2968 0.131727638010901 4226 41468073 SGTC_342 k048-0088 23.3 µM -1.11836955167207 0.122483457503971 no 2969 0.131704596508186 4202 6820570 SGTC_2636 apigenin dimethyl ether 100 µM -1.11906008207891 0.12233814557739 no 2970 0.131557253971316 4205 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2403 6032726 181.2 µM -1.12093262286346 0.121944706125745 no 2971 0.131158271659292 4265 2881040 SGTC_3096 9117468 49.47 µM -1.12193570440585 0.121734314647048 no 2972 0.130944889172269 4114 41316311 SGTC_959 1222-0044 107 µM -1.1223344062435 0.121650759752537 no 2973 0.130860141202471 4214 6083612 SGTC_2262 9014885 67.46 µM -1.12239651600123 0.121637747203221 no 2974 0.130846942580095 4188 6457424 SGTC_1852 st056254 31.4 µM -1.12508104573231 0.12107624886232 no 2975 0.130277346221714 4159 442583 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.12861220749928 0.120340448531899 no 2976 0.129530729356757 4249 4174840 SGTC_94 0334-0113 514.748 µM -1.1295067364852 0.120154553532582 no 2977 0.129342064699794 4239 6795178 SGTC_1121 fusaric acid 630.51 nM -1.1324260497025 0.119549289557393 no 2978 0.128727679100574 4182 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1735 st034310 56.75 µM -1.13364219511202 0.119297780665384 no 2979 0.128472332980461 4287 871153 SGTC_491 tetrandrine 80.3 µM -1.14225153070823 0.117527975501983 no 2980 0.126674740973907 4242 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3216 9129716 49.47 µM -1.15006878030643 0.115937171330305 no 2981 0.125057771837661 4181 8056934 SGTC_20 0481-0013 4.944 µM -1.15031802341981 0.115886703268325 no 2982 0.125006455056549 4280 182045 SGTC_3261 9137475 49.47 µM -1.15142620102489 0.11566250248194 no 2983 0.124778469946068 4184 17027690 SGTC_1746 st038117 42 µM -1.15274696114136 0.115395695748318 no 2984 0.124507130001957 4288 2898218 SGTC_1313 1220-0047 237 µM -1.1535049640961 0.115242769274648 no 2985 0.124351590611317 4217 3528706 SGTC_1471 k673-0312 37 µM -1.15579724317224 0.114781180619445 no 2986 0.123882050473486 4183 24099884 SGTC_3308 9128332 17.569 µM -1.15872103775212 0.114194336670116 no 2987 0.123284956330846 4256 17332805 YDL196W YDL196W SGTC_2985 9022375 71.43 µM -1.1609954987874 0.11373930249395 no 2988 0.122821864980436 4312 4939335 SGTC_2898 9056270 58.44 µM -1.16350009385581 0.113239723976264 no 2989 0.122313330033034 4241 19154699 SGTC_431 k089-0097 107 µM -1.16379369412113 0.113181263731062 no 2990 0.122253814126024 4045 5499420 SGTC_1413 3910-0535 34.4 µM -1.16483680864188 0.112973738044602 no 2991 0.122042528112701 4277 2876951 SGTC_528 3492-0019 172 µM -1.16549061616342 0.112843802800349 no 2992 0.121910228223536 4248 2869262 SGTC_2002 4023503 131 µM -1.16634012633616 0.112675133767321 no 2993 0.121738477856667 4262 4736863 YCR052W RSC6 SGTC_3250 9135583 49.47 µM -1.1666851190792 0.112606687379597 no 2994 0.121668777251425 4292 7699353 SGTC_2916 7875993 68.79 µM -1.1705072455087 0.111850365781752 no 2995 0.12089845004009 4094 1299250 SGTC_2032 5185112 25.99 µM -1.17077630638377 0.11179726127234 no 2996 0.120844351995572 4144 5718189 SGTC_3049 9092223 49.47 µM -1.17455066537484 0.111054216672558 no 2997 0.120087265348898 4241 8623917 SGTC_2772 vinpocetine 57.06 µM -1.17571206944071 0.110826288406009 no 2998 0.119854976978275 4282 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_339 3091-4833 71.4 µM -1.17685644671895 0.110602029707135 no 2999 0.119626404108123 4123 3240077 SGTC_2546 rhodinyl acetate 100 µM -1.17911065429575 0.110161234094673 no 3000 0.119177058325194 4223 6708682 SGTC_2944 9067346 25.62 µM -1.18125889733491 0.109742333174059 no 3001 0.118749945124224 4217 6473075 SGTC_636 0kpi-0074 126 µM -1.18219862727903 0.109559448616822 no 3002 0.11856344860261 4272 616434 SGTC_847 0342-0274 5.54 µM -1.18317610268123 0.109369450587787 no 3003 0.118369680923987 4271 18097 SGTC_3111 9122088 49.47 µM -1.18576003279598 0.108868335951012 no 3004 0.117858539609827 4120 16876704 SGTC_2384 9036245 200 µM -1.18801666265952 0.108432048447262 no 3005 0.117413422530574 4205 6462766 SGTC_446 go6976 132 µM -1.18806400947546 0.108422908102788 no 3006 0.117404096204898 4308 3501 A protein kinase C inhibitor. SGTC_2774 tamoxifen 10.92 µM -1.18977990145986 0.10809202767034 no 3007 0.117066455562629 4254 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_577 r071-0003 38.6 µM -1.19024109586886 0.10800321829781 no 3008 0.116975822539294 4256 4568517 YMR134W ERG29 SGTC_58 0957-0393 9 µM -1.19298848868139 0.107475258365554 no 3009 0.116436940678289 3979 6997992 SGTC_3002 9075603 71.4286 µM -1.19332617045106 0.107410495447117 no 3010 0.116370828484522 4216 20105405 SGTC_280 3448-3607 3.04 µM -1.19387897193799 0.10730453612367 no 3011 0.116262657097574 4236 626179 SGTC_200 k038-0079 37.545 µM -1.19542504344991 0.107008589950844 no 3012 0.115960502957799 4256 3436683 SGTC_2160 5660466 132.927 µM -1.19730554872742 0.106649421203122 no 3013 0.115593741244782 4199 2859134 SGTC_2046 4110841 106 µM -1.19807271502255 0.106503145773525 no 3014 0.115444354964041 4271 44119630 YMR134W ERG29 SGTC_2469 5655019 90.81 µM -1.19966996538752 0.106199063223429 no 3015 0.115133771032404 4336 2788239 SGTC_1420 4'-methoxyflavone 42 µM -1.2011391795019 0.105919910250888 no 3016 0.114848608627873 4268 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1899 st063254 59.6 µM -1.20155302395016 0.105841374969618 no 3017 0.114768375586576 4228 3093813 SGTC_1905 st060207 84.5 µM -1.20489269717364 0.105209144932626 no 3018 0.114122364094843 4276 1948547 SGTC_1287 0971-0001 34.6 µM -1.20514823122636 0.105160882835023 no 3019 0.114073041613507 4282 4665869 SGTC_1797 st048695 56.8 µM -1.20632224454162 0.104939355671079 no 3020 0.113846631933182 4253 592262 YIL048W NEO1 SGTC_2385 9074692 200 µM -1.20718078607772 0.1047775695692 no 3021 0.113681264158281 4317 17046906 SGTC_2477 5967686 25.23 µM -1.20753229007179 0.104711383258615 no 3022 0.113613608726874 4275 776118 SGTC_1028 k015-0029 4.8 µM -1.20775090168152 0.104670235143696 no 3023 0.113571546124576 4257 4588309 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.20836070779292 0.104555516443965 no 3024 0.113454273292678 4238 279621 SGTC_999 SEC7.066 22.7 µM -1.20932074451287 0.104375095848482 no 3025 0.113269822067271 4247 740511 YDR170C SEC7 SGTC_916 4466-0038 42 nM -1.21151380405778 0.103963798692542 no 3026 0.112849273710374 4348 5722064 YGL116W CDC20 SGTC_1255 0566-0045 221 µM -1.21189386200256 0.103892640416294 no 3027 0.112776506015318 4312 2788469 SGTC_2097 5376186 200 µM -1.21310832252296 0.103665493683416 no 3028 0.112544204238778 4281 742755 SGTC_2658 polymyxin b sulfate 77.05 µM -1.21443887143839 0.103417048231475 no 3029 0.112290089680095 4321 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3215 9129942 49.47 µM -1.21460021979265 0.103386950025404 no 3030 0.11225930250154 4279 17682944 SGTC_710 3448-4187 58 µM -1.21812719618045 0.102730609620182 no 3031 0.111587820229009 4273 3946412 SGTC_1357 1503-1303 39.5 µM -1.22054913802293 0.102281663808057 no 3032 0.111128386956093 4284 292895 SGTC_2543 pimpinellin 60.67 µM -1.22284483195699 0.101857439012201 no 3033 0.110694154389646 4135 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_283 0987-0079 11.7 µM -1.22612909253482 0.101252764291099 no 3034 0.110075049724422 4304 411556 SGTC_2463 5473429 200 µM -1.22626016001958 0.101228687466823 no 3035 0.110050394293987 4294 5399405 SGTC_550 4123-0385 25.7 µM -1.22738584579076 0.101022073092978 no 3036 0.109838801878326 4320 5731123 SGTC_3118 9124250 49.47 µM -1.22849370000371 0.100819031920164 no 3037 0.109630846457927 4261 1504786 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.23036188798228 0.10047731540645 no 3038 0.109280809257591 4272 688761 SGTC_2012 4023501 200 µM -1.23106936679508 0.100348128944549 no 3039 0.109148460746043 4326 3477460 SGTC_70 0141-0289 43.283 µM -1.23152186859987 0.100265565167837 no 3040 0.109063871362074 4268 352408 SGTC_1949 st076024 69.1 µM -1.23184652831163 0.100206358100142 no 3041 0.109003209446553 4245 2921930 SGTC_2 0422-0095 29 µM -1.23190246095197 0.100196160435839 no 3042 0.108992761011648 4210 6790840 SGTC_2507 purpurin 79.67 µM -1.23192510280598 0.100192032578179 no 3043 0.108988531629895 4307 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2512 diallyl trisulfide 49.23 µM -1.2330455501231 0.0999879178201841 no 3044 0.108779385178949 4350 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2919 7978188 46.38 µM -1.23442500042029 0.0997370371010025 no 3045 0.108522288934478 4328 2980291 SGTC_1583 clindamycin 39.6 µM -1.23458260297924 0.0997084032114474 no 3046 0.1084929434682 4280 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_273 hydroxyurea 18.1 mM -1.23503680868349 0.0996259148245006 no 3047 0.108408402676915 4377 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2906 7926292 26.41 µM -1.23741132197376 0.0991954906737822 no 3048 0.107967208810116 4315 2966319 SGTC_2415 st077333 57.7 µM -1.23770683930882 0.0991420180253149 no 3049 0.107912391132382 4352 2766255 SGTC_1969 st069479 40.1 µM -1.24056125270305 0.0986266085034653 no 3050 0.107383936641598 4322 3895485 SGTC_1041 0206-0046 107 µM -1.24435256358408 0.0979450636742987 no 3051 0.106684916661748 4317 50494 SGTC_1693 xanthone 101.9 µM -1.24612410253691 0.0976277888702975 no 3052 0.106359418700424 4368 7020 An insecticide. SGTC_1962 st076595 64.5 µM -1.24887815887638 0.0971360470404239 no 3053 0.105854820614251 4298 279619 SGTC_1352 1496-0991 99 µM -1.24889855431481 0.0971324121904773 no 3054 0.105851090228404 4323 3000039 SGTC_2248 tofa 1.1 µM -1.2491393780972 0.0970895004201355 no 3055 0.105807050032868 4322 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2107 5363541 170.161 µM -1.25085300686931 0.0967845550214378 no 3056 0.105494055793747 4284 244052 SGTC_1081 sertraline 6 µM -1.25113389408161 0.0967346374635109 no 3057 0.105442815696693 4308 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1042 0350-0096 82 µM -1.25146336034526 0.0966761108323415 no 3058 0.10538273664013 4315 3122515 SGTC_1253 0550-0034 176 µM -1.25198809790694 0.0965829497681308 no 3059 0.105287100471839 4360 5969915 SGTC_92 0063-0024 660.874 µM -1.25570464475321 0.0959250070515002 no 3060 0.1046115372919 4420 3594437 SGTC_851 0394-0702 453 µM -1.25653324049766 0.0957787706351496 no 3061 0.10446135099871 4339 762646 SGTC_3164 9100705 49.47 µM -1.25964203020218 0.0952315714143645 no 3062 0.103899263112252 4330 17174235 SGTC_145 3737-0113 38.366 µM -1.26268173234608 0.0946987619537892 no 3063 0.103351790816319 4303 6849351 SGTC_2087 5276107 200 µM -1.26490054869931 0.0943112296351053 no 3064 0.102953490324766 4290 144405 SGTC_520 3584-0023 682 µM -1.26688629245731 0.0939653980239113 no 3065 0.102597975374781 4354 1340790 SGTC_892 0929-0076 29 µM -1.27003996939127 0.0934180871754729 no 3066 0.102035196553464 4318 5751038 SGTC_1392 3455-1037 33.9 µM -1.27112896393268 0.0932296435584213 no 3067 0.101841386385544 4332 981132 SGTC_1553 gossypol 38.6 µM -1.27331656476924 0.0928519421900651 no 3068 0.101452865501886 4226 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2735 sertaconazole 140 nM -1.2750168377668 0.0925591629865418 no 3069 0.101151641176409 4494 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_503 tyrphostin 8 294 µM -1.27903725545124 0.0918695831946152 no 3070 0.100441968438988 4374 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_207 4185-0010 4.486 µM -1.28020192138505 0.0916705329385746 no 3071 0.10023706518621 4431 3761753 SGTC_826 1683-5028 118 µM -1.28119207771368 0.0915015591574694 no 3072 0.100063104048289 4382 722377 SGTC_2897 9048598 12.99 µM -1.28124881207362 0.0914918842293483 no 3073 0.10005314303726 4319 6467404 SGTC_1867 st057372 64 µM -1.28137729574576 0.0914699766713701 no 3074 0.100030587474359 4308 688837 SGTC_1951 sophoraflavanone G 9.2 µM -1.28795105668949 0.0903542765609167 no 3075 0.0988815004609514 4307 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1737 st035557 69.7 µM -1.28802298993392 0.0903421241836101 no 3076 0.0988689802438099 4202 5716916 SGTC_3246 9135460 32.98 µM -1.29554441280903 0.0890781463070132 no 3077 0.0975662453623455 4329 41446951 SGTC_3178 9107506 49.47 µM -1.29929841491199 0.0884522304160553 no 3078 0.0969207690695109 4367 8897194 SGTC_1252 0493-0875 34.8 µM -1.30118448527101 0.0881389997817612 no 3079 0.0965976572598255 4349 3960963 SGTC_233 rapamycin 362 pM -1.30241329966298 0.0879353687928587 no 3080 0.0963875692774178 4354 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_506 n9-isopropylolomoucine 153 µM -1.30373208302896 0.0877172192736824 no 3081 0.0961624732283113 4378 6610355 SGTC_3168 9103419 49.47 µM -1.30597235458908 0.0873475655706284 no 3082 0.0957809795320737 4396 16649256 SGTC_1971 st069429 63.5 µM -1.31452447359528 0.0859471218187021 no 3083 0.0943348838569015 4368 1246522 YGL099W LSG1 SGTC_2398 5228213 48.84 µM -1.31695576531891 0.0855520720148836 no 3084 0.0939267261711113 4345 80771 YMR134W ERG29 SGTC_893 0958-0369 48.9 µM -1.31764907519508 0.0854396687126966 no 3085 0.0938105746332635 4279 6819948 SGTC_2754 granisetron 64.02 µM -1.31846065663481 0.0853082311255903 no 3086 0.0936747435727844 4377 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2065 5221596 34.26 µM -1.32010985938765 0.0850416054876684 no 3087 0.093399170722015 4334 788581 SGTC_2671 danthron 100 µM -1.32076134158047 0.0849364530125957 no 3088 0.0932904767370994 4369 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2475 5812728 15.03 µM -1.32427188787193 0.0843715104407518 no 3089 0.0927063817047245 4341 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3269 9137823 49.47 µM -1.3260179667902 0.0840915709070669 no 3090 0.0924168731176071 4318 17682936 SGTC_768 0384-0033 77.3 µM -1.32683456916893 0.083960888959531 no 3091 0.0922817061978186 4335 3965305 YMR134W ERG29 SGTC_3093 9117344 49.47 µM -1.33860707817738 0.0820938297521935 no 3092 0.0903493103207068 4404 24824913 SGTC_1793 st048256 72.231 µM -1.34086284242715 0.0817396756589144 no 3093 0.0899824941367823 4354 672022 SGTC_398 bronopol 33.3 µM -1.34340916216391 0.0813412896118984 no 3094 0.0895697608811565 4321 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2825 7998094 58.44 µM -1.34370484975216 0.0812951227058944 no 3095 0.0895219242251606 4370 2987815 SGTC_1187 1391-0724 117 µM -1.34576234410008 0.0809744249198838 no 3096 0.0891895865414856 4444 6997986 SGTC_1161 k007-0610 110 µM -1.35692905093704 0.0792505267511496 no 3097 0.0874018775457474 4356 5843850 SGTC_1662 st014054 52 µM -1.35808738970403 0.0790733070506807 no 3098 0.0872179780499212 4474 2838777 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.36415003567324 0.0781506472689714 no 3099 0.0862601748680744 4432 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3137 9097352 49.47 µM -1.36593104328574 0.07788115782801 no 3100 0.0859803040028224 4427 44120435 SGTC_1726 st035556 14.5795 µM -1.37080668503089 0.0771470184243391 no 3101 0.0852176132296347 4450 5919439 SGTC_2162 5663267 200 µM -1.37115750834597 0.0770943974347641 no 3102 0.0851629304832281 4424 6456493 SGTC_1774 st048371 48.465 µM -1.37159837503 0.0770283092635317 no 3103 0.0850942499863694 4406 4242727 SGTC_1757 st041620 31.8375 µM -1.38076214735261 0.0756643424905973 no 3104 0.0836760528279127 4457 5289815 SGTC_2659 sanguinarine 24.21 µM -1.38350015863176 0.0752603987782263 no 3105 0.0832557793596002 4375 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3009 9080819 71.4286 µM -1.39015774923967 0.0742850531321596 no 3106 0.0822404901101568 4440 17027216 SGTC_287 k060-0039 29.6 µM -1.39121090512428 0.0741316526906082 no 3107 0.0820807406680797 4463 5861974 SGTC_1828 st055811 49 µM -1.39244385253228 0.0739523717958964 no 3108 0.0818940164705762 4443 5877589 SGTC_3124 9127567 49.47 µM -1.39379473184588 0.0737563231606981 no 3109 0.0816897997348286 4390 17592030 SGTC_671 0560-0003 407 µM -1.39384131693288 0.0737495695143058 no 3110 0.0816827641726937 4363 3238678 SGTC_2531 methyl deoxycholate 70.07 µM -1.39827710242256 0.0731086569821243 no 3111 0.0810149355572261 4375 16667744 Haematoxylin. SGTC_2911 7942208 15.64 µM -1.39945118440549 0.0729397330457707 no 3112 0.0808388635741851 4446 1243384 SGTC_1177 0983-0204 23.6 µM -1.40795500507416 0.071725131017251 no 3113 0.0795721969373582 4461 766818 SGTC_2071 5230951 39.92 µM -1.40803986645711 0.0717130889204294 no 3114 0.0795596327283882 4483 1799272 SGTC_2556 citropten 84.59 µM -1.41006658581282 0.0714259516748055 no 3115 0.0792600112850684 4451 2775 A potential DNA crosslinker. SGTC_625 k213-0058 121 µM -1.41278133707987 0.0710427204592899 no 3116 0.0788600136695824 4510 3655420 SGTC_1573 oleylamine 1.06 µM -1.41434939646412 0.0708220840315467 no 3117 0.0786296700669101 4440 5356789 An amine of the fatty acid oleic acid. SGTC_2034 5197015 53.07 µM -1.41655934799591 0.0705120234010387 no 3118 0.078305900517966 4440 780676 SGTC_1672 st016598 6.51 µM -1.41859946956664 0.0702267175177701 no 3119 0.0780079103089468 4408 4665860 YNL267W PIK1 SGTC_3133 9127736 49.47 µM -1.42131592420655 0.0698482073174106 no 3120 0.0776124680756324 4457 27243420 SGTC_1813 st051246 8.6015 µM -1.42172993378193 0.0697906574530311 no 3121 0.0775523333869508 4401 5291959 SGTC_2290 7904846 200 µM -1.42974651516233 0.0686834849256044 no 3122 0.0763948923577329 4495 2962154 SGTC_1137 ixabepilone 100 µM -1.43178646659278 0.0684039200928136 no 3123 0.0761024707711725 4398 154225 A novel microtubule stabilizer. SGTC_1720 st037298 9.481 µM -1.4383504479524 0.0675103158311585 no 3124 0.0751673223624538 4448 597396 SGTC_1691 st019933 84.6 µM -1.43835653977602 0.0675094907156171 no 3125 0.0751664585688635 4440 6176082 SGTC_272 doxorubicin 8.13 µM -1.44052965944406 0.0672156464275049 no 3126 0.0748588024972672 4499 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2996 9066192 71.4286 µM -1.44580779147208 0.0665060675520757 no 3127 0.0741155600722888 4452 6472854 SGTC_2508 celastrol 40.54 µM -1.45062614894187 0.0658633756188333 no 3128 0.0734419949341979 4395 122724 Celastrol is a natural product and antioxidant. SGTC_35 0133-0054 64.071 µM -1.45220828879246 0.0656533964568907 no 3129 0.0732218493318808 4438 99677 SGTC_262 fenpropimorph 62.5 µM -1.45735361604057 0.0649741039554998 no 3130 0.072509396905557 4495 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2316 5844804 197.44 µM -1.45806270231674 0.0648809187913522 no 3131 0.0724116303884109 4491 776813 SGTC_2716 st080858 38.6235 µM -1.45862404308063 0.0648072233341061 no 3132 0.0723343061918103 4457 5296050 SGTC_855 0428-0020 25 µM -1.4620588647873 0.0643576985476523 no 3133 0.0718625398894127 4486 6812414 SGTC_352 k048-0007 5.11 µM -1.46643707963025 0.0637882262675948 no 3134 0.0712646254483005 4408 6811911 SGTC_1893 st059353 36.1 µM -1.47363580333843 0.0628604219171541 no 3135 0.0702898380145484 4477 3112488 SGTC_91 0417-1751 58.384 µM -1.47478759241481 0.0627129547662137 no 3136 0.0701348290117754 4574 6795624 SGTC_687 k029-0044 34.9 µM -1.47852547890772 0.0622362382400413 no 3137 0.069633591274661 4544 5829338 SGTC_754 3474-0146 171 µM -1.47971059368989 0.0620856845922617 no 3138 0.0694752486231745 4475 24762078 SGTC_3322 9139058 2.11 µM -1.48208501079453 0.0617849004319926 no 3139 0.0691588383028165 4512 4908926 YPR165W RHO1 SGTC_1653 st012112 65 µM -1.48635544164546 0.0612467988974545 no 3140 0.0685925645950945 4475 720429 SGTC_2050 5263056 171 µM -1.48650772674129 0.0612276778396965 no 3141 0.0685724373085235 4476 763468 YGL055W OLE1 SGTC_61 0978-8327 98.565 µM -1.49602642613898 0.0600417328001792 no 3142 0.0673233844360024 4412 6150059 YHR072W ERG7 SGTC_1687 st020778 55.3625 µM -1.49627681156886 0.0600107815480597 no 3143 0.0672907676166343 4509 4259299 SGTC_838 0109-0203 71.4 µM -1.49652595900413 0.059979995733284 no 3144 0.0672583241934309 4514 759422 SGTC_1336 1486-0901 104 µM -1.50007679430429 0.0595425810228171 no 3145 0.066797255628053 4502 5006114 SGTC_2156 5649887 115 µM -1.5023064652536 0.0592691962146171 no 3146 0.0665089898575041 4517 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1658 st012944 20 µM -1.50367283692264 0.0591021494261829 no 3147 0.0663328132915332 4342 24207260 SGTC_356 1634-0012 32.5 µM -1.5044653850426 0.0590054252217454 no 3148 0.0662307898324738 4494 735457 SGTC_681 1642-0006 26.6 µM -1.50453321554459 0.0589971528199162 no 3149 0.0662220637688115 4500 4446530 SGTC_1666 st014829 29 µM -1.50634389255959 0.0587766642932439 no 3150 0.06598945798271 4504 3858230 SGTC_3125 9127534 49.47 µM -1.50716061436063 0.0586774228827308 no 3151 0.0658847464931764 4413 1639235 SGTC_56 0957-0365 83.25 µM -1.50731283834346 0.0586589404094522 no 3152 0.0658652441777015 4428 6752360 SGTC_1166 k206-0078 225 µM -1.51407599765049 0.0578423850606937 no 3153 0.0650032827595404 4521 5404595 SGTC_450 aminopyrene 156 nM -1.5236720978163 0.0566991584462638 no 3154 0.063795321440606 4471 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1638 st008370 60.6 µM -1.52640368941556 0.0563770072929275 no 3155 0.0634546796995802 4445 24207134 SGTC_331 k048-0133 24.5 µM -1.54192062362736 0.0545743048638062 no 3156 0.0615464418146585 4497 6813582 SGTC_1428 4049-0204 61.7 µM -1.54326021387654 0.0544208382582447 no 3157 0.0613838263937872 4550 X1428 SGTC_2020 4017018 200 µM -1.54966090816626 0.0536922666271864 no 3158 0.0606114627695108 4545 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_742 0kpi-0133 140 µM -1.55042605148273 0.0536056920891456 no 3159 0.0605196448698149 4555 2728852 SGTC_2144 5628481 200 µM -1.55272052149516 0.0533467399816292 no 3160 0.0602449587376491 4508 2818399 SGTC_22 0964-0034 14.468 µM -1.55440713846835 0.0531570226984368 no 3161 0.060043665777908 4534 138402 SGTC_362 0310-0100 9.03 µM -1.5556163088449 0.0530213399862812 no 3162 0.059899679127894 4544 790235 SGTC_2594 a-mangostin 100 µM -1.55611403532691 0.0529655692511881 no 3163 0.0598404890480381 4518 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_563 tetrahydrosecaminediol 614 µM -1.56016284347806 0.0525136231956407 no 3164 0.0593607018937559 4565 334274 A psychoactive constituent of the cannabis plant. SGTC_3021 9087658 49.47 µM -1.56401818979846 0.0520861225440411 no 3165 0.0589066483693538 4539 25237042 SGTC_2595 hexamethylquercetagetin 100 µM -1.56464589763311 0.0520167815006001 no 3166 0.0588329803374125 4512 386331 SGTC_2003 4023581 200 µM -1.56560967155417 0.0519104589929062 no 3167 0.0587200122036051 4539 16641307 SGTC_386 1509-0011 3.07 µM -1.56588507457657 0.051880108571557 no 3168 0.0586877623141964 4535 3107280 SGTC_861 0443-0273 110 µM -1.56631912556456 0.0518323031914623 no 3169 0.0586369628607637 4520 6149169 SGTC_2652 actinonin 100 µM -1.56703556148571 0.0517534731716554 no 3170 0.0585531898106002 4574 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2583 asiatic acid 100 µM -1.57028945215789 0.0513966435447362 no 3171 0.058173893481606 4535 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1333 1482-0047 286 µM -1.57452440929026 0.0509351616798508 no 3172 0.0576831314870866 4570 3811116 SGTC_376 3970-0862 59.1 µM -1.57610882394724 0.0507633587750636 no 3173 0.057500362915388 4550 3135186 SGTC_1297 1068-0111 14.1 µM -1.57822451887948 0.0505346673764457 no 3174 0.0572570196648738 4525 767057 SGTC_542 3381-0244 89.3 µM -1.57928581327201 0.0504202586080433 no 3175 0.0571352571964471 4553 1112843 SGTC_2793 7325131 81.82 µM -1.59261071300807 0.0490013127378573 no 3176 0.0556237743669993 4507 4176441 SGTC_1640 st009078 66.4 µM -1.59527283617183 0.0487216879297315 no 3177 0.055325618618305 4509 690618 SGTC_2239 6685329 187.64 µM -1.59938575070239 0.0482921835131038 no 3178 0.0548674582315738 4551 805680 SGTC_3208 9114115 49.47 µM -1.60010603161778 0.048217278445173 no 3179 0.054787531581617 4499 650895 SGTC_3144 9087057 49.47 µM -1.60101026021527 0.0481233755025239 no 3180 0.0546873233304208 4465 17249618 SGTC_2642 cholecalciferol 100 µM -1.60241753758207 0.0479775227697367 no 3181 0.0545316546258816 4550 9821465 A vitamin D precursor, similar to steriods. SGTC_3334 9142812 21.919 µM -1.60629401220973 0.0475775871690057 no 3182 0.0541046626827344 4546 45283678 SGTC_1325 1431-0015 227 µM -1.60812109543741 0.0473900153049246 no 3183 0.0539043299323265 4546 1103340 SGTC_2025 5147754 141 µM -1.60865065547257 0.0473357605580012 no 3184 0.0538463755921242 4537 315777 YLR208W SEC13 SGTC_2201 6605497 169.863 µM -1.61140682433346 0.0470541874097397 no 3185 0.053545540394191 4515 670741 SGTC_131 0141-0277 33.849 µM -1.61214014655672 0.0469794970558818 no 3186 0.0534657231304345 4506 1547771 SGTC_557 1315-0110 16.2 µM -1.61758638908005 0.0464277569392116 no 3187 0.0528758821525308 4538 6833801 SGTC_1302 1159-0335 255 µM -1.61882424687762 0.0463030821270016 no 3188 0.0527425417965952 4580 649284 SGTC_307 1501-1223 22.3 µM -1.63032216955274 0.0451578339712604 no 3189 0.0515167122153128 4581 2830329 SGTC_672 1441-0018 53.7 µM -1.63360854534749 0.0448347171502152 no 3190 0.051170536184322 4560 251141 SGTC_2552 juarezic acid 87.02 µM -1.63372866103124 0.0448229427168582 no 3191 0.0511579187412804 4515 1549512 SGTC_1008 4106-0037 6 µM -1.63914071498019 0.0442950001130577 no 3192 0.0505919786492378 4587 2905394 SGTC_1801 st050089 28.441 µM -1.63999595757449 0.044212032140328 no 3193 0.0505030037304809 4602 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2266 7929956 200 µM -1.64592004978144 0.0436407634544141 no 3194 0.0498901102268804 4516 2967153 SGTC_3119 9125183 49.47 µM -1.64832752088938 0.0434103163600928 no 3195 0.049642740115656 4465 22695334 SGTC_2681 menadione 3.18 µM -1.65144030377531 0.0431138130439267 no 3196 0.0493243504094601 4593 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_970 1315-0089 19.5 µM -1.6548492850767 0.0427909748579336 no 3197 0.0489775368866455 4553 6811083 YLR033W RSC58 SGTC_1113 artemisinin 1.17947 µM -1.66654580300682 0.0416981145316264 no 3198 0.047802376654903 4599 2240 An anti-malaria and mitochondrial poison. SGTC_3076 9116187 49.47 µM -1.66771925446998 0.041589732639173 no 3199 0.0476857356611117 4582 27241210 SGTC_1251 0490-5699 265 µM -1.67103805957196 0.0412844374283947 no 3200 0.0473570802482173 4582 3883818 SGTC_2896 9052656 71.43 µM -1.67355713933444 0.0410539233772736 no 3201 0.0471088339847188 4261 6469436 SGTC_2362 9071156 126 µM -1.67671319251385 0.0407665958853338 no 3202 0.0467992898022148 4581 653133 SGTC_1022 4477-0945 21.3 µM -1.682643550718 0.0402311098799707 no 3203 0.0462220577734409 4534 4648966 SGTC_1136 pergolide 1.05886 µM -1.69108886636666 0.0394784097470366 no 3204 0.045409915649723 4514 47811 A dopamine receptor agonist. SGTC_1842 st055362 61.2 µM -1.69123843876721 0.0394651828600983 no 3205 0.0453956361520559 4550 676032 SGTC_2330 7979373 200 µM -1.6960508497791 0.0390415352865196 no 3206 0.044938125271703 4512 1863007 SGTC_464 bw-b 70c 158 µM -1.69606892648643 0.0390399509603474 no 3207 0.0449364137615404 4577 5353454 SGTC_2643 anethole 100 µM -1.69811649046065 0.0388608314696979 no 3208 0.0447428888927816 4592 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1096 rimcazole 32.2 µM -1.69864992257444 0.0388142772570337 no 3209 0.0446925820781937 4553 18528119 A dopamine reuptake inhibitor. SGTC_2484 5809818 12.04 µM -1.70041960091247 0.0386601573831101 no 3210 0.0445260137526024 4557 2870548 SGTC_3131 9127911 49.47 µM -1.70324047826774 0.0384155205631375 no 3211 0.0442615372029758 4582 45595681 SGTC_744 1594-0068 283 µM -1.7158545309668 0.0373369763684807 no 3212 0.043094335282624 4585 668392 SGTC_2920 7982904 15.77 µM -1.71604282073038 0.037321066289672 no 3213 0.0430771026710136 4569 6456808 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.71818245649722 0.0371406604451536 no 3214 0.0428816702156744 4614 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1323 1348-1351 11.2 µM -1.71927637405141 0.0370487012148842 no 3215 0.0427820299077158 4594 6989654 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.72041947051497 0.0369528067286148 no 3216 0.042678110134423 4617 23665772 A membrane-active detergent. SGTC_546 peri-Naphthalide 147 µM -1.722357243704 0.0367907103302669 no 3217 0.0425024119629521 4559 223824 A penicillin ester. SGTC_247 mechlorethamine 29.705 µM -1.72491674452012 0.036577497612771 no 3218 0.0422712387461521 4575 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_384 k007-0144 5.16 µM -1.72551351523086 0.0365279307466061 no 3219 0.0422174851352431 4566 6824886 SGTC_1288 0973-0013 65.5 µM -1.72628162006018 0.0364642140343633 no 3220 0.0421483801738223 4624 4315430 SGTC_561 1550-0330 72.9 µM -1.72687139402997 0.0364153521791196 no 3221 0.0420953814603253 4568 6812934 SGTC_3108 9121785 49.47 µM -1.72983991561517 0.0361702277620798 no 3222 0.0418294403520616 4482 17140271 SGTC_2729 fluphenazine 10.66 µM -1.73236832704174 0.035962512172883 no 3223 0.0416040017721163 4569 3372 An atypical antipsychotic. SGTC_1924 st058459 75.1 µM -1.73361612317792 0.0358603631330014 no 3224 0.041493108885078 4575 688683 SGTC_1778 st046819 58.9 µM -1.74361451760934 0.0350504147579435 no 3225 0.0406131650529047 4639 671715 SGTC_426 0988-0037 14.6 µM -1.74502645988353 0.0349372555206919 no 3226 0.0404901316129885 4604 5383008 SGTC_1719 st032227 49.2 µM -1.74613417185559 0.0348486886946183 no 3227 0.0403938200742502 4588 3125804 SGTC_692 k241-0027 77.8 µM -1.74913277544448 0.0346098606133979 no 3228 0.0401340354690278 4632 3600480 SGTC_1133 3473-0247 50 µM -1.74969092830978 0.0345655544780959 no 3229 0.0400858299529088 4576 711311 SGTC_1007 4101-0031 70 µM -1.75354685832196 0.0342607422069156 no 3230 0.0397540918272511 4602 1146276 SGTC_2788 5282734 71.43 µM -1.75591763742913 0.0340744307443436 no 3231 0.0395512364616992 4613 743706 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.75633583059326 0.0340416529619399 no 3232 0.0395155413279497 4592 97141 SGTC_939 1165-0479 45.3 µM -1.76076204250174 0.0336963155145321 no 3233 0.0391393434066396 4583 1377347 SGTC_3233 9132340 49.47 µM -1.76465756584035 0.0333947728720218 no 3234 0.0388106671699599 4628 17682950 SGTC_405 ebelactone b 50 µM -1.76667387051331 0.0332395705798777 no 3235 0.0386414308880013 4586 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1 0258-0098 57.368 µM -1.77437199956552 0.032652472485247 no 3236 0.0380008191219333 4539 6790032 YDR047W HEM12 SGTC_3026 9090633 49.47 µM -1.77630740304157 0.0325062217847096 no 3237 0.0378411318465795 4631 25236842 SGTC_1620 st003704 16.5 µM -1.78125471419023 0.0321348279380744 no 3238 0.037435424470079 4634 2834414 SGTC_2662 daunorubicin 22.37 µM -1.7826179089534 0.0320331109575891 no 3239 0.0373242612646677 4507 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2602 kawain 100 µM -1.78355810475599 0.0319631117547663 no 3240 0.0372477492118822 4583 5369129 SGTC_1846 st056244 14.8 µM -1.78720683476387 0.0316926528605369 no 3241 0.0369520325295695 4635 5393182 SGTC_231 b-estradiol 524 µM -1.79172967182551 0.0313600291705193 no 3242 0.0365881395641107 4635 450 A steroid. SGTC_2860 9025725 38.96 µM -1.79331042670649 0.0312444583832951 no 3243 0.0364616505551884 4653 40546248 SGTC_1685 st024049 53.0905 µM -1.8039339394032 0.0304768679901655 no 3244 0.0356208318209889 4651 1941139 SGTC_2638 epoxomicin 18 µM -1.82536614137165 0.028975819349962 no 3245 0.0339728975910012 4602 9915668 A protesome inhibitor. SGTC_3260 9137109 49.47 µM -1.82732070504927 0.028842038725302 no 3246 0.0338257819496279 4637 17478346 SGTC_2153 5569715 200 µM -1.83953251138956 0.0280177767067707 no 3247 0.0329184502702739 4657 2054701 SGTC_1657 st012939 43.4 µM -1.85205967624519 0.0271927076547853 no 3248 0.0320086270211437 4642 24207257 SGTC_1118 chelidonine 707.474 nM -1.85554187507893 0.0269669957350499 no 3249 0.0317594426018814 4636 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_62 0180-0423 3.232 µM -1.85623046575446 0.0269225478225474 no 3250 0.0317103576854839 4601 30102 YGL099W LSG1 SGTC_1637 st007924 17.4 µM -1.85654144495999 0.0269024944484483 no 3251 0.0316882106618177 4571 683336 SGTC_3197 9113331 49.47 µM -1.86203935337019 0.0265500179694718 no 3252 0.0312987716871919 4615 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_359 0081-0058 15.9 µM -1.86211088894769 0.026545457301696 no 3253 0.0312937307374648 4620 3494159 SGTC_2537 larixol 68.93 µM -1.87322366322638 0.025844881073724 no 3254 0.0305187529991264 4619 6708759 SGTC_313 3474-0040 5.03 µM -1.87510285748144 0.025727955113677 no 3255 0.0303892872643928 4661 1043375 YIL048W NEO1 SGTC_2198 6589944 200 µM -1.88354271102207 0.0252082623002891 no 3256 0.0298134286600828 4665 5290268 SGTC_2752 diclazuril 33.15 µM -1.88501801965993 0.0251183279993337 no 3257 0.0297137025086921 4569 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2396 5342950 42.78 µM -1.89118315758692 0.024745408222671 no 3258 0.0292999494164253 4629 1886677 SGTC_785 1270-0111 65.3 µM -1.89265955394716 0.0246567958325118 no 3259 0.0292015792079602 4578 6741994 SGTC_1194 1488-0194 225 µM -1.89860410979283 0.0243026968981333 no 3260 0.0288082738273121 4657 1391452 SGTC_758 0868-0029 16 µM -1.9042990426352 0.0239674819398498 no 3261 0.0284356244254122 4595 762687 SGTC_982 1491-0518 27.5 µM -1.90540916744606 0.0239025924019855 no 3262 0.0283634522383295 4636 3091256 SGTC_2664 lyso-paf C-16 73.48 µM -1.91274821036913 0.0234773118340629 no 3263 0.027890147048167 4659 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2629 bisabolol 100 µM -1.91984403782885 0.0230721959393926 no 3264 0.0274388012131712 4654 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1676 st018489 23.4 µM -1.92108494822956 0.0230019579600929 no 3265 0.0273604994369069 4613 3696235 SGTC_440 fluspirilene 35.1 µM -1.92334468849098 0.0228745147587529 no 3266 0.0272183878896465 4651 3396 An atypical antipsychotic. SGTC_2619 obliquin 87.91 µM -1.9256992759642 0.0227423558194275 no 3267 0.0270709671781845 4642 6708593 A bioactive alkalod. YER133W GLC7 SGTC_432 NS 1619 61.3 µM -1.92930112282808 0.0225414357561421 no 3268 0.0268467452222786 4617 4552 A K+/calcium channel activator. SGTC_2756 carbadox 75.1 µM -1.93529985179893 0.0222101340096422 no 3269 0.0264767552635625 4584 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2340 7987427 183.45 µM -1.93921586500424 0.0219960819930072 no 3270 0.0262375292911122 4636 2239331 SGTC_2275 7947463 200 µM -1.94272560925463 0.0218057194319679 no 3271 0.0260246601455901 4638 1225414 SGTC_1832 st054113 55 µM -1.95384268772406 0.0212119078264145 no 3272 0.0253599120881121 4693 1251267 SGTC_1097 itavastatin 7.23 µM -1.97469468759037 0.0201349640137681 no 3273 0.0241514030846118 4688 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3007 9078383 71.4286 µM -1.97744029015537 0.0199966775533458 no 3274 0.0239959417789565 4671 6496995 SGTC_2887 9044784 58.44 µM -1.98629541273925 0.0195561531579431 no 3275 0.0235002658541493 4601 6465546 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.98738425710116 0.0195025587093985 no 3276 0.0234399154561755 4692 65057 A dermal irritant. YDR527W RBA50 SGTC_442 cape 100 µM -1.99895130575661 0.0189408737445145 no 3277 0.0228068113721809 4697 5281787 SGTC_905 2-aminofluorene 215 µM -2.00490508171225 0.0186571678619657 no 3278 0.0224865976757286 4703 1539 An established DNA mutagen. YPR165W RHO1 SGTC_184 1494-0393 24.714 µM -2.00705288532875 0.0185557136364725 no 3279 0.0223720160758227 4661 3090647 SGTC_1468 k284-1086 134 µM -2.0104148661752 0.0183978494220827 no 3280 0.022193649183596 4674 15996457 SGTC_2368 9071271 200 µM -2.01304648408746 0.0182750794332084 no 3281 0.0220548696890679 4677 27209959 SGTC_430 0958-0115 16.4 µM -2.01598210516023 0.0181389514349423 no 3282 0.0219009235242296 4633 6833180 SGTC_3058 9093861 49.47 µM -2.01866125350136 0.018015471599448 no 3283 0.0217612198948514 4702 17217477 SGTC_2738 aclarubicin 5.55 µM -2.0284114010067 0.0175721272242392 no 3284 0.0212591387329333 4725 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_953 1188-0045 9.7 µM -2.0371213305723 0.017183990829532 no 3285 0.0208189424163166 4658 6144426 SGTC_1326 1431-2094 10.8 µM -2.03943448738617 0.0170821502752578 no 3286 0.0207033416934193 4700 616278 SGTC_848 0368-0089 85.6 µM -2.04858137922301 0.0166844809122259 no 3287 0.0202515334994142 4692 762535 SGTC_1349 flufenamic acid 69 µM -2.06378422355952 0.016041045071197 no 3288 0.0195190897744313 4646 3371 A non-steroidal anti-inflammatory. SGTC_2327 6189656 200 µM -2.08312843465453 0.0152531765499745 no 3289 0.0186197590776395 4717 5349088 SGTC_439 amiodarone 34.4 µM -2.08605758860602 0.0151368213412009 no 3290 0.0184867034149274 4587 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1874 staurosporine 7.6 µM -2.09133382831646 0.014929155993103 no 3291 0.0182490747003139 4706 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_444 curcumin 90.4 µM -2.09385721158394 0.0148307080908482 no 3292 0.0181363509424877 4620 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2033 5192550 145 µM -2.09813466005562 0.0146651017803703 no 3293 0.0179466257762555 4704 182073 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -2.10037083678001 0.0145791606864626 no 3294 0.0178481161774865 4690 61125 An anti-inflammatory. SGTC_2741 miltefosine 3.04 µM -2.10130057707948 0.0145435565271704 no 3295 0.0178072945692339 4745 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_100 0086-0128 49.5915 µM -2.10142936114093 0.0145386306811187 no 3296 0.0178016464017019 4692 93297 SGTC_814 3342-0569 96 µM -2.10232085182783 0.0145045715188293 no 3297 0.017762589598101 4723 4346283 SGTC_2485 5633444 17.78 µM -2.11729808922264 0.0139425566374114 no 3298 0.0171172784868827 4682 5724239 SGTC_457 grayanotoxin iii 135 µM -2.11946148068876 0.0138629484523091 no 3299 0.0170257428763446 4527 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_170 4197-0004 226 µM -2.12546381023359 0.0136441248250639 no 3300 0.0167739653620468 4693 218692 SGTC_2795 7780010 54.55 µM -2.12737160286292 0.0135752006017334 no 3301 0.0166946098403805 4675 953673 SGTC_2467 5474540 200 µM -2.1302387308403 0.013472182978149 no 3302 0.0165759544918286 4704 5413519 SGTC_2453 5731132 22.18 µM -2.13696303155368 0.0132332190104161 no 3303 0.0163004992882183 4727 1362040 SGTC_1488 4013-0813 75.9 µM -2.14688967617363 0.0128871483725916 no 3304 0.0159010328543025 4739 2910057 SGTC_3205 9113483 49.47 µM -2.16478933760881 0.0122828710422359 no 3305 0.0152019108635434 4670 17018033 SGTC_2779 methotrexate 400 µM -2.16621761757265 0.0122357287624032 no 3306 0.0151472807477798 4688 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_489 paxilline 115 µM -2.16688246281919 0.0122138381917702 no 3307 0.0151219087453866 4687 105008 A toxic potassium channel blocker. SGTC_2895 9054447 58.44 µM -2.17986596264496 0.0117930985214361 no 3308 0.0146336993163061 4748 2697450 SGTC_465 cgp-37157 41 µM -2.18985590679752 0.0114779840573201 no 3309 0.014267344323981 4765 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2302 7771753 200 µM -2.21485180462637 0.0107213873316719 no 3310 0.0133851190387195 4685 2203047 SGTC_695 3505-6186 243 µM -2.21760910842255 0.0106406477980321 no 3311 0.0132907481556488 4710 1819379 SGTC_1642 st009582 77.7 µM -2.23230774769132 0.0102191175180436 no 3312 0.0127973150855675 4732 6739311 SGTC_171 k064-0041 9.68 µM -2.23934438062317 0.0100225271439841 no 3313 0.0125667586481354 4704 53325 SGTC_1630 st005209 31.3 µM -2.2449124130449 0.00986931406703755 no 3314 0.0123868779541531 4719 3367314 SGTC_2692 st077426 47.7 µM -2.24858577880776 0.00976935901172459 no 3315 0.0122694310191019 4715 25238571 SGTC_1105 epirubicin 18.1 µM -2.26666829382257 0.0092901057733488 no 3316 0.0117052483430342 4745 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_285 1486-1325 46 µM -2.28788947580776 0.00875401226338782 no 3317 0.011071979171918 4755 22310230 SGTC_308 4092-1169 104 µM -2.2946429134384 0.00858919150355767 no 3318 0.0108767984148192 4709 2268590 YDL196W YDL196W SGTC_2604 4'-hydroxychalcone 11.32 µM -2.33397126912647 0.00768239468343731 no 3319 0.00979861319185391 4712 5282362 SGTC_1375 2910-0797 186 µM -2.334752213855 0.00766527587836439 no 3320 0.00977818443440629 4743 742508 SGTC_185 k048-0037 25.491 µM -2.35779323868846 0.00717508523777629 no 3321 0.00919196460458273 4769 6827589 SGTC_704 1310-0270 142 µM -2.38799325950771 0.00657457005030746 no 3322 0.00847032624221828 4736 5718033 SGTC_2150 5556613 200 µM -2.40516919747932 0.00625324087864447 no 3323 0.00808248979991281 4767 743190 SGTC_1195 1502-0147 41.1 µM -2.44023709471424 0.00564005668843654 no 3324 0.00733881260356821 4773 817940 SGTC_203 k066-0004 30.888 µM -2.46925985364762 0.00517358695474297 no 3325 0.00676964303729641 4776 6795412 SGTC_385 1494-0393 12.4 µM -2.51810636785004 0.0044655943837127 no 3326 0.00589938417344927 4758 3090647 SGTC_2792 7535235 81.82 µM -2.55464850095324 0.00399391388263095 no 3327 0.00531475387235143 4726 1281891 SGTC_864 0469-0573 172 µM -2.56532879043991 0.00386474691395346 no 3328 0.00515390388962784 4756 689425 SGTC_3191 9110352 49.47 µM -2.56616176341228 0.00385483210127795 no 3329 0.005141542987826 4746 17122424 SGTC_798 1287-0182 476 µM -2.57256778949343 0.00377934028501088 no 3330 0.00504735922767459 4775 1649755 SGTC_159 3970-0959 50 µM -2.63957140745454 0.00306562274199209 no 3331 0.00415054666882138 4763 6615653 SGTC_281 1672-3440 14.9 µM -2.6887585326395 0.00262157460097192 no 3332 0.00358591381608561 4788 6833000 SGTC_3278 9139605 49.47 µM -2.69864301275696 0.00253968656107124 no 3333 0.00348114081145953 4760 7958859 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -2.7135457195623 0.00242059070537154 no 3334 0.00332836909506076 4780 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2406 ethylparaben 405.7 µM -2.73704673440636 0.00224301985934907 no 3335 0.00309967426708276 4745 8434 A possible steroid mimic. SGTC_802 4112-3352 742 µM -2.85735202261558 0.00150559604134094 no 3336 0.0021359588597957 4783 704594 SGTC_1134 3477-0009 42.5 µM -2.85889670385201 0.001497768963741 no 3337 0.00212558594989735 4761 3973534 SGTC_800 3448-7362 155 µM -2.86204455511851 0.00148193322917512 no 3338 0.00210458865358224 4797 15991913 SGTC_2737 bleomycin 30.5 nM -2.95331356153988 0.00108421359081988 no 3339 0.00157191223572486 4804 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2801 7907800 81.82 µM -3.06612162871321 0.000728385432461677 yes 3340 0.00108427540648199 4768 6620925 SGTC_1100 amiodarone 5.07 µM -3.20003687911572 0.000446750396380117 yes 3341 0.000687050020039028 4802 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2967 9089538 49.85 µM -3.25992727230631 0.000356924593238718 yes 3342 0.000557203927939845 4785 728216 SGTC_2625 euphol 100 µM -3.29927755502434 0.000307372478067239 yes 3343 0.000484670088170575 4785 6708538 A triterpene alcohol. SGTC_2284 7945075 39.21 µM -3.34413443348432 0.000258725401400451 yes 3344 0.00041269865192995 4778 1245402 SGTC_2430 5571206 200 µM -3.3792856950399 0.000225727188247211 yes 3345 0.00036337221295406 4781 1731771 SGTC_2857 9024691 58.44 µM -3.68929708753192 6.41731388115694e-05 yes 3346 0.000112437250469944 4792 16478292 SGTC_204 PMA1.184 62.41 µM -3.73540817332881 5.27798678061522e-05 yes 3347 9.37054790411043e-05 4803 2252213 YGL008C PMA1 SGTC_2283 7944793 200 µM -3.93384898452871 2.22006951547671e-05 yes 3348 4.17981585574058e-05 4803 2970533 SGTC_1722 st034304 3.6505 µM -4.10945241890326 9.97462101395228e-06 yes 3349 1.98299208736318e-05 4800 4036148 YLR033W RSC58 SGTC_160 3453-0671 289.699 µM -4.67163312828109 6.2156733128581e-07 yes 3350 1.49407163848813e-06 4802 5322268 SGTC_2433 5607874 27.82 µM -4.84800063285856 2.43213862794641e-07 yes 3351 6.23560016178419e-07 4808 2252428