SGTCid condition conc unit YJR039W|YJR039W.score YJR039W|YJR039W.strain.pval YJR039W|YJR039W.strain.significant YJR039W|YJR039W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2350 9023895 38.85 µM 6.33854145291952 6.43402023547283e-13 yes 1 1.15975219090052e-10 8 2997209
SGTC_3069 9117009 49.47 µM 5.15068790650123 3.84217183739866e-09 yes 2 1.29766378549471e-07 5 41904981
SGTC_1079 idarubicin 2.36 µM 5.10074374323726 5.33500026748243e-09 yes 3 1.69160685980369e-07 12 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2935 9038016 29.96 µM 4.75565581494639 4.74829848861818e-08 yes 4 9.89016131935907e-07 7 6463195
SGTC_2483 5729050 27.16 µM 3.82259758503205 8.58369507806882e-06 yes 5 6.60265957943064e-05 31 2865180
SGTC_1309 pyrazolanthrone 13.4 µM 3.74365245958829 1.27061201360503e-05 yes 6 9.06822350975534e-05 26 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1250 0485-0349 40.2 µM 3.68709160213848 1.67527133490796e-05 yes 7 0.000113415860701527 43 6842794 YDL195W SEC31
SGTC_581 0958-0271 211 µM 3.56318003699724 3.0297140067941e-05 yes 8 0.000183194605044515 65 4591145
SGTC_1334 1486-0610 236 µM 3.3180595993629 9.27464566500669e-05 yes 9 0.000453225704180878 39 3742339
SGTC_893 0958-0369 48.9 µM 3.23237548394455 0.000134872963592374 yes 10 0.000613828127111313 56 6819948
SGTC_458 nppb 133 µM 3.21105892898635 0.000147844101871497 yes 11 0.000661234062386683 30 4549 A chloride channel blocker.
SGTC_608 k048-0125 159 µM 3.19846906868781 0.000156044627942217 yes 12 0.000690796766714282 57 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3007 9078383 71.4286 µM 3.00364298085385 0.000351413130834788 yes 13 0.00133384083226133 51 6496995
SGTC_1217 1183-1422 255 µM 2.94497876038378 0.000444859594276756 yes 14 0.00161488416720409 53 2849664
SGTC_3001 9076041 71.4286 µM 2.92904463676234 0.000473956207548403 yes 15 0.00170002796022664 51 16004211
SGTC_1430 4049-0248 69.1 µM 2.92580007868946 0.000480092910207557 yes 16 0.00171785824475615 71 22774488
SGTC_1454 4239-0054 42.6 µM 2.8978367096128 0.000536115211239873 yes 17 0.00187873082343369 88 1340767
SGTC_1642 st009582 77.7 µM 2.85734100050869 0.000628023392418831 yes 18 0.00213603304058225 64 6739311
SGTC_1332 1480-0653 17.5 µM 2.81743452708287 0.000732634985487195 yes 19 0.00242044916960684 72 5749438
SGTC_567 1080-0542 68.4 µM 2.78422885226043 0.000831677738747169 yes 20 0.00268275808614996 54 5950415
SGTC_3073 9114972 49.47 µM 2.77004672821685 0.000877618764235194 yes 21 0.00280241255310634 63 41905075
SGTC_2461 5755302 26.15 µM 2.73941513153774 0.000984911003302123 yes 22 0.00307743015487314 109 2788904
SGTC_110 0850-0284 111.64 µM 2.73254431305261 0.0010105741470593 no 23 0.00314236083366397 45 3906265
SGTC_1073 triclabendazole 3.09 µM 2.73020817329359 0.00101943868426912 no 24 0.00316471717513424 113 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1686 st019653 115.5 µM 2.7254318179293 0.00103778512420855 no 25 0.00321087191603307 52 97252
SGTC_3071 9117417 49.47 µM 2.72336608466943 0.00104581322505271 no 26 0.00323102038528121 63 45595590 YGL055W OLE1
SGTC_2303 7774051 200 µM 2.71697263887852 0.00107102253697803 no 27 0.00329410269246618 76 2953184
SGTC_2594 a-mangostin 100 µM 2.66743843454487 0.00128603229361794 no 28 0.00382159455662463 103 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1832 st054113 55 µM 2.60616946919282 0.00160632721130865 no 29 0.00457805735911241 57 1251267
SGTC_1291 0993-0025 5.79 µM 2.60266106976434 0.00162670165378142 no 30 0.00462516759000954 69 4353356
SGTC_1066 ketoconazole 628 nM 2.56903879879966 0.00183423754401634 no 31 0.00509905193817033 106 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1327 1436-0082 2.18 µM 2.56774361400401 0.00184269367406039 no 32 0.00511814173178908 100 15992205
SGTC_577 r071-0003 38.6 µM 2.55278911585506 0.00194292978747666 no 33 0.00534320886135663 176 4568517 YMR134W ERG29
SGTC_798 1287-0182 476 µM 2.54966988668699 0.00196445143256074 no 34 0.00539124813631944 121 1649755
SGTC_284 0988-0104 32.6 µM 2.54145002101786 0.00202220674341056 no 35 0.00551968639357582 82 4666532
SGTC_1938 st074717 56.4 µM 2.53888122614975 0.00204056947510817 no 36 0.00556037851159787 68 17250979
SGTC_786 4544-0069 423 µM 2.53571185721787 0.00206343382613459 no 37 0.00561095135013986 138 748821 YLR208W SEC13
SGTC_2335 9018011 154.17 µM 2.49965431119374 0.00234042181080472 no 38 0.00621572728198946 134 6458208
SGTC_1269 0831-0796 3.05 µM 2.49884247287485 0.00234702853050884 no 39 0.00622998418988702 99 927758
SGTC_1496 4469-0713 57.4 µM 2.49744925027677 0.0023584059008146 no 40 0.00625451844420333 103 746691
SGTC_2933 9026794 32.47 µM 2.45523023034012 0.00272775029095653 no 41 0.00703971919542997 138 17586027
SGTC_112 phenothiazine 287.218 µM 2.40279517104133 0.00325876087723101 no 42 0.00813514895606877 101 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1436 4092-1007 8.32 µM 2.39784739052819 0.00331338182140788 no 43 0.00824586730415249 110 2881121
SGTC_1257 0669-0121 16 µM 2.39164522312363 0.00338301253532548 no 44 0.00838652344717803 151 4307855
SGTC_593 1203-0218 61.7 µM 2.38673948627519 0.00343901691982805 no 45 0.00849926597665809 114 3666956
SGTC_2298 7976326 193.81 µM 2.38579902312742 0.00344984800453761 no 46 0.00852103076882817 87 2235818
SGTC_988 1497-1057 103 µM 2.3798536219595 0.00351903182187962 no 47 0.00865975818894313 121 3533044
SGTC_1828 st055811 49 µM 2.35475365462823 0.00382504189859224 no 48 0.00926749437616953 89 5877589
SGTC_3076 9116187 49.47 µM 2.35324229665272 0.00384420731274909 no 49 0.00930525143743324 121 27241210
SGTC_1125 tnp00248 1.32998 µM 2.34969511154408 0.00388952734366602 no 50 0.00939439703395428 204 24207736
SGTC_2763 lisinopril 49.32 µM 2.34682373720306 0.00392656295986674 no 51 0.0094671047790684 85 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2834 9001755 58.44 µM 2.34317237564101 0.00397411515455724 no 52 0.00956027344209032 148 2989575
SGTC_2596 sinensetin 100 µM 2.27779265184584 0.0049174367548802 no 53 0.0113694671719771 155 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2886 9058944 51.95 µM 2.27611696031822 0.00494403944964788 no 54 0.0114195051147587 53 4949929
SGTC_2602 kawain 100 µM 2.24943601752509 0.00538523584028657 no 55 0.0122423846238779 186 5369129
SGTC_3003 9075612 71.4286 µM 2.24390570930455 0.00548094838469465 no 56 0.0124192343681305 161 6501993
SGTC_2439 5492030 7.2 µM 2.21899291099448 0.00593110968718578 no 57 0.013243603409687 131 5722370
SGTC_886 0866-0150 153 µM 2.2148479986677 0.00600910671750893 no 58 0.0133852496995144 193 271463
SGTC_1983 st071813 46.9 µM 2.21397084524066 0.00602572867710803 no 59 0.0134153922849471 149 11838595
SGTC_155 k072-0202 43.6 µM 2.21327163501943 0.00603900781138168 no 60 0.0134394619778106 136 5857737
SGTC_813 k007-0158 173 µM 2.21232198211678 0.00605708479209276 no 61 0.0134722126441266 208 6523916
SGTC_1340 1486-1359 257 µM 2.20564942036324 0.00618545725230471 no 62 0.013704277964642 165 4309068
SGTC_111 0083-0039 52.457 µM 2.20289049987905 0.0062392360917505 no 63 0.0138012336881254 65 759313
SGTC_762 1165-0429 115 µM 2.19767226078458 0.00634208697021686 no 64 0.0139862348368564 156 5967793
SGTC_1909 st060837 51.5 µM 2.19254595446814 0.00644458430186022 no 65 0.0141700543396809 205 678937
SGTC_1136 pergolide 1.05886 µM 2.18262025884252 0.00664721633594895 no 66 0.0145318933077225 267 47811 A dopamine receptor agonist.
SGTC_2918 7977171 22.06 µM 2.16338926978345 0.0070558990136338 no 67 0.0152556260880426 163 2236483
SGTC_2770 toltrazuril 17.5 µM 2.15744479189993 0.00718663602278893 no 68 0.0154855121891671 191 68591 Kills coccidiodes.
SGTC_1346 1488-2224 62.4 µM 2.14466510340239 0.00747495575741786 no 69 0.0159898164651096 157 3722427
SGTC_3162 9099653 49.47 µM 2.13134975565684 0.00778615351481464 no 70 0.0165301694371015 119 25237511
SGTC_2545 solidagenone 89.61 µM 2.11449684304936 0.00819633630217321 no 71 0.0172364270589412 71 6708572 An anti ulcer agent
SGTC_2318 6029776 164 µM 2.08854195122967 0.00886519836047968 no 72 0.018374487639802 218 818325
SGTC_182 3448-4371 550.524 µM 2.08244964284836 0.00902896240097763 no 73 0.0186507090127686 198 3491403
SGTC_575 k072-0246 11.9 µM 2.08183172316875 0.00904571943937028 no 74 0.0186789215112602 195 6796779
SGTC_2547 epiafzelechin trimethyl ether 100 µM 2.0768816545475 0.00918094361292422 no 75 0.0189062416800144 83 6708630 An antioxidant.
SGTC_2466 5983409 37.09 µM 2.07134677285579 0.00933423590550944 no 76 0.0191632006098842 182 2879657
SGTC_360 0957-0399 1.01 µM 2.04027095109618 0.0102371605503786 no 77 0.0206616732063557 238 6752301 YPR165W RHO1
SGTC_855 0428-0020 25 µM 2.02304174875892 0.0107698757544954 no 78 0.0215344217012529 178 6812414
SGTC_1372 2752-0194 270 µM 2.02138785669707 0.0108222605113421 no 79 0.0216198153800519 186 823334
SGTC_910 3454-3003 490 µM 2.01865102861626 0.0109094330108224 no 80 0.0217617516349866 234 820824
SGTC_366 0181-0206 4.31 µM 2.01795904826885 0.0109315702699579 no 81 0.021797763247978 266 274874
SGTC_1871 st057448 67.3 µM 2.00370960397773 0.0113961955689659 no 82 0.0225505884452353 240 691747
SGTC_3066 9117245 49.47 µM 1.99842888465384 0.0115726885597964 no 83 0.022835091360429 207 17176980
SGTC_2863 9028737 58.44 µM 1.9955435966195 0.0116701201307784 no 84 0.0229918121000703 152 6460917
SGTC_2645 abamectin 100 µM 1.99533849243301 0.0116770732011803 no 85 0.0230029871886576 230 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2321 7390090 138.78 µM 1.99393047129799 0.0117249025331337 no 86 0.0230798266941239 209 649046
SGTC_133 0724-0033 378.92 µM 1.9925873314716 0.011770686271389 no 87 0.0231533267724855 200 280309
SGTC_2126 5251174 33.877 µM 1.97122689420731 0.01251992766958 no 88 0.0243489645065113 307 790722
SGTC_465 cgp-37157 41 µM 1.9706164331684 0.0125419337586687 no 89 0.0243838827658487 136 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_937 3122-0005 46.7 µM 1.95978444229723 0.0129380140522156 no 90 0.0250104952053625 252 759535
SGTC_1855 st056195 39.6 µM 1.95046095779821 0.0132875507733806 no 91 0.0255606012206557 236 4028379
SGTC_2891 9063876 19.48 µM 1.94703944571243 0.0134178536176801 no 92 0.0257650028888451 131 6472478
SGTC_473 2-arachidonoylglycerol 10 µM 1.94671827437308 0.0134301413720266 no 93 0.0257842597530477 236 5282280 An endocannabinoid.
SGTC_1785 bathophenanthroline 24 µM 1.93813725004233 0.0137620610799772 no 94 0.0263032399571955 281 72812 An iron chelator.
SGTC_618 k072-0232 33.2 µM 1.93028639905671 0.014071911851254 no 95 0.0267856806641749 216 5872756 YGL099W LSG1
SGTC_645 0845-0943 5.41 µM 1.92149886353796 0.0144258441626797 no 96 0.0273344227530557 217 1885106
SGTC_1191 1487-1166 10.6 µM 1.91851411982112 0.0145477907280005 no 97 0.0275229267414159 285 3955771
SGTC_1343 1487-0095 224 µM 1.91722933134024 0.0146005553786651 no 98 0.027604401645752 202 4560101 YGL055W OLE1
SGTC_808 0711-0032 135 µM 1.91691001593558 0.0146136947839026 no 99 0.0276246822050072 218 4252555
SGTC_2479 5617353 43.85 µM 1.91662934775626 0.0146252523079157 no 100 0.0276425184314765 272 2731746
SGTC_2469 5655019 90.81 µM 1.91250239200473 0.0147961047794579 no 101 0.0279058930520168 256 2788239
SGTC_445 e6 berbamine 66 µM 1.90262912949461 0.0152118292734598 no 102 0.0285444777032476 410 6610268 A calcium/calmodulin antagonist.
SGTC_193 1273-0060 1.558 µM 1.89651891163368 0.0154741013261558 no 103 0.0289457308443084 165 2847393 YHR072W ERG7
SGTC_2045 5106652 78.05 µM 1.89297526255862 0.0156279784183204 no 104 0.0291805796312772 211 673349
SGTC_1494 4358-1428 177 µM 1.8884479771061 0.0158264769994383 no 105 0.0294829178293658 261 1564571
SGTC_2143 5623677 140.463 µM 1.8883141321871 0.0158323781790788 no 106 0.0294918956016277 178 5375313
SGTC_1685 st024049 53.0905 µM 1.88761205039117 0.0158633636589345 no 107 0.0295390255722729 215 1941139
SGTC_443 clozapine 122 µM 1.8850857883733 0.0159752875468768 no 108 0.0297091282174789 167 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_442 cape 100 µM 1.88274916098338 0.0160794117795681 no 109 0.0298671848501369 202 5281787
SGTC_2130 NSC 7 2.4545 µM 1.8809211491775 0.0161612761878706 no 110 0.0299913229004779 281 21448
SGTC_2201 6605497 169.863 µM 1.87763299755974 0.01630942953098 no 111 0.0302156942109738 196 670741
SGTC_1251 0490-5699 265 µM 1.87128972246343 0.0165985250406102 no 112 0.0306524671530123 308 3883818
SGTC_1061 3448-9325 110 µM 1.87090649722796 0.01661613017876 no 113 0.0306790211508023 200 723482
SGTC_2443 5493264 126.67 µM 1.87001251714308 0.0166572612156217 no 114 0.0307410398329427 244 5340055
SGTC_3278 9139605 49.47 µM 1.86820145669215 0.0167408531737282 no 115 0.030866997916382 259 7958859
SGTC_2348 9022543 33.42 µM 1.86397416193514 0.0169373671787929 no 116 0.0311626664444202 270 3162678 YDL140C RPO21
SGTC_135 0933-0004 26.348 µM 1.84993495011739 0.0176042205391141 no 117 0.0321614628893088 276 21230617 YGL099W LSG1
SGTC_2288 7946289 167.31 µM 1.84590878062372 0.0177995471823246 no 118 0.0324527257592746 313 1246052
SGTC_1955 wogonin 32.4 µM 1.84309048995647 0.0179373719252053 no 119 0.0326578998092696 251 5281703 A flavanone.
SGTC_2899 9053889 58.44 µM 1.84066199077011 0.018056863414392 no 120 0.0328355536139671 204 6470052
SGTC_1834 st055981 52.8 µM 1.83497145054534 0.0183395205315325 no 121 0.0332549598514858 285 471719 YDL150W RPC53
SGTC_1220 1838-0075 193 µM 1.83149330741418 0.0185141340564279 no 122 0.0335134728627639 279 5529645
SGTC_258 haloperidol 50.781 µM 1.82419572712831 0.0188851001652823 no 123 0.0340612436764119 316 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_185 k048-0037 25.491 µM 1.81719857303121 0.019246713857291 no 124 0.0345933567020193 248 6827589
SGTC_632 0781-2353 4.65 µM 1.81710397785124 0.0192516425866783 no 125 0.0346005969004376 314 6811515 YHR007C ERG11
SGTC_1033 k072-0102 21.3 µM 1.81496750877583 0.0193632459117773 no 126 0.0347644513897866 311 5965931
SGTC_998 3996-0085 177 µM 1.80419091236238 0.0199346009756739 no 127 0.0356006917438599 321 715391
SGTC_1379 2144-0755 36.5 µM 1.79676718502191 0.0203364611759607 no 128 0.0361862939670829 310 5392327
SGTC_873 0591-4978 488 µM 1.79596332031221 0.0203803850756948 no 129 0.0362501753805346 294 3305145
SGTC_2121 5257820 149.641 µM 1.79089654303215 0.020659092936179 no 130 0.03665494927552 298 791256
SGTC_1719 st032227 49.2 µM 1.78293293342081 0.0211036680691212 no 131 0.0372986106461584 295 3125804
SGTC_2324 6149169 200 µM 1.77971252208933 0.0212857348870765 no 132 0.0375615100459549 254 2888231
SGTC_564 3555-0129 330 µM 1.77762154001492 0.0214046589569648 no 133 0.0377330168233118 204 563260
SGTC_1565 sinapyl alcohol 95.1 µM 1.77709255876745 0.0214348335044385 no 134 0.0377765061451805 296 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2255 7941087 197.44 µM 1.77604654095952 0.0214946071095483 no 135 0.0378626232067396 328 935561
SGTC_1395 3486-0190 4.35 µM 1.76016584401675 0.0224195385073558 no 136 0.0391898456869665 297 6748079
SGTC_1333 1482-0047 286 µM 1.75689598449162 0.0226140936839734 no 137 0.0394677701094253 330 3811116
SGTC_1039 k821-0043 94 µM 1.75671539102914 0.0226248802608659 no 138 0.039483166402928 303 15992768
SGTC_1272 0839-0021 27 µM 1.75560872118517 0.022691074758092 no 139 0.0395776210348541 310 5027250
SGTC_2491 paeonol 100 µM 1.75327710405752 0.0228310727827391 no 140 0.0397772268151222 248 11092 Increases levels of cortical cytochrome oxidase.
SGTC_989 1501-0895 10.3 µM 1.75118826668943 0.0229571108765143 no 141 0.0399567429439883 253 2830112
SGTC_2685 mycophenolic acid 18.85 µM 1.75096869198588 0.0229703937440248 no 142 0.0399756515291492 242 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1590 st077108 57.8 µM 1.74922599699015 0.0230760454092539 no 143 0.0401259810082121 250 5489485
SGTC_1222 0366-0074 1.18 µM 1.74495947006794 0.0233364339655624 no 144 0.0404959621076538 301 286520
SGTC_2919 7978188 46.38 µM 1.74301228922174 0.0234560907883973 no 145 0.0406657340975198 313 2980291
SGTC_2756 carbadox 75.1 µM 1.7383604968951 0.0237440405932425 no 146 0.0410736563540441 370 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2065 5221596 34.26 µM 1.7281095228872 0.0243890873443814 no 147 0.0419842952594571 306 788581
SGTC_739 1486-1183 203 µM 1.72459389931695 0.0246136703873353 no 148 0.0423003418251572 320 4346692
SGTC_351 caspofungin 25 nM 1.72078654457227 0.0248588443427919 no 149 0.0426447824724606 463 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3226 9131256 49.47 µM 1.71934938352987 0.0249519210077997 no 150 0.042775386451421 156 17178073
SGTC_2693 st077581 40.7 µM 1.71537208434001 0.0252110323074661 no 151 0.0431385150649744 411 25238761
SGTC_2025 5147754 141 µM 1.71161348614654 0.0254579642537271 no 152 0.043483960669123 278 315777 YLR208W SEC13
SGTC_1050 3232-1156 69.3 µM 1.69555379288669 0.0265359837482912 no 153 0.0449852073874494 330 700529
SGTC_1502 4534-4282 27.7 µM 1.69354122288065 0.0266737301203807 no 154 0.0451762476011276 273 3278949
SGTC_1202 1988-0068 29.6 µM 1.69017855488978 0.0269052136476111 no 155 0.0454968999096949 336 2850480
SGTC_411 enrofloxacin 100 µM 1.66264177822414 0.0288646307943079 no 156 0.0481920814991821 324 71188 A bacterial gyrase inhibitor.
SGTC_281 1672-3440 14.9 µM 1.66121869825458 0.0289690343793121 no 157 0.0483347657783589 342 6833000
SGTC_1071 trifluoperazine 6.31 µM 1.66002302915413 0.0290569965158424 no 158 0.048454909892017 370 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1134 3477-0009 42.5 µM 1.65926177515173 0.0291131154551818 no 159 0.0485315271333674 391 3973534
SGTC_398 bronopol 33.3 µM 1.65659084408703 0.0293107267021401 no 160 0.0488011123563143 353 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_283 0987-0079 11.7 µM 1.65390290820002 0.0295107193752515 no 161 0.0490736208354924 384 411556
SGTC_3214 9129694 49.47 µM 1.65260617599574 0.0296076054958906 no 162 0.0492055201664759 334 17158655
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.64791171294149 0.0299605654469886 no 163 0.0496853947459626 366 5393153
SGTC_48 0382-0018 55 µM 1.64675950655048 0.0300477270582972 no 164 0.0498037437878203 294 762596
SGTC_1164 k060-0068 93.7 µM 1.64588283828554 0.0301141856363684 no 165 0.049893941447409 375 5963676
SGTC_2771 fluoxetine 41.05 µM 1.64291409843159 0.0303401459192869 no 166 0.0502003538089028 310 3386 A selective serotonin reuptake inhibitor.
SGTC_1877 wortmannin 25 µM 1.64039669571204 0.0305328526375862 no 167 0.0504613559668194 431 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2014 4013930 200 µM 1.63606792647823 0.03086658922866 no 168 0.0509126859616784 428 64556
SGTC_794 k038-0031 316 µM 1.63310702730861 0.0310966012545202 no 169 0.0512232444470782 455 6624242
SGTC_1671 st016596 74.5 µM 1.63075043013198 0.0312806810496389 no 170 0.0514714954013842 375 2829167
SGTC_3343 9148379 18.9835 µM 1.62856997600346 0.0314518036354782 no 171 0.0517020422422585 346 1955036
SGTC_493 zm226600 134 µM 1.62739117216682 0.0315446382904265 no 172 0.0518270226132753 378 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2634 4'-methoxyflavone 100 µM 1.62584322986831 0.0316668876732219 no 173 0.0519915046969408 354 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2584 androsterone 48.74 µM 1.623563197737 0.031847666947956 no 174 0.0522345326257279 526 2754130 A steroid.
SGTC_1799 st045822 46.1415 µM 1.62125072453339 0.0320318883367384 no 175 0.0524819390776169 329 3674992
SGTC_3042 9091578 49.47 µM 1.61203486412997 0.0327748241216845 no 176 0.0534771766254249 285 25236497
SGTC_2055 5235184 200 µM 1.61182490544158 0.0327919140538271 no 177 0.0535000234761145 376 2836034
SGTC_464 bw-b 70c 158 µM 1.61034029230395 0.0329129663229837 no 178 0.0536617937954019 410 5353454
SGTC_2115 tiliquinol 12.7705 µM 1.60403272481547 0.0334313857398409 no 179 0.0543534197175852 311 71208 A bioactive hydroxyquinoline.
SGTC_2316 5844804 197.44 µM 1.60001074953531 0.0337654489079768 no 180 0.0547980993623826 478 776813
SGTC_600 1495-0418 41.6 µM 1.59609784164046 0.0340930840310439 no 181 0.055233475253687 349 5377768
SGTC_2981 9013952 38.96 µM 1.59607989441911 0.0340945927863582 no 182 0.0552354784557528 363 2996344
SGTC_1206 3978-0017 132 µM 1.58575519960056 0.0349716953982348 no 183 0.0563974260144038 351 3873677
SGTC_1908 st060353 56.5 µM 1.58535755932304 0.0350058426609177 no 184 0.0564425590615916 437 4227716
SGTC_3323 9138564 53.9225 µM 1.58489550587217 0.0350455557566209 no 185 0.0564950388964042 423 43912313 YNL103W MET4
SGTC_2898 9056270 58.44 µM 1.57375991405058 0.0360138864840836 no 186 0.0577714823114036 308 19154699
SGTC_1620 st003704 16.5 µM 1.57339418718688 0.0360460574261355 no 187 0.0578137860679211 347 2834414
SGTC_1562 morin hydrate 59.1 µM 1.56534614573621 0.0367599762756996 no 188 0.0587508842854031 383 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_865 0488-0499 301 µM 1.56203134352148 0.0370573659354209 no 189 0.0591403025983606 408 9634651
SGTC_2208 7283366 200 µM 1.55516899272161 0.0376792764384072 no 190 0.0599529134789844 382 898663
SGTC_97 0535-0701 19.132 µM 1.55066361597127 0.0380921968041393 no 191 0.0604911590632859 369 2832013 YGL099W LSG1
SGTC_2398 5228213 48.84 µM 1.53878292591393 0.0391987914541213 no 192 0.0619286497647889 493 80771 YMR134W ERG29
SGTC_3346 9158254 43.5805 µM 1.53667691930515 0.0393976534373691 no 193 0.0621862229495265 416 17639500
SGTC_381 3461-2219 42.7 µM 1.52679392023704 0.0403418573133493 no 194 0.0634061319454979 416 2883159
SGTC_1356 1502-0781 85.8 µM 1.52592760027232 0.0404254926452764 no 195 0.0635139480713498 396 567702
SGTC_933 2914-0560 114 µM 1.52239990621351 0.0407675144763476 no 196 0.0639544541632692 455 463887
SGTC_1875 nocodazole 6 µM 1.52131686477945 0.0408729888355506 no 197 0.0640901700406082 395 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2994 9053520 71.4286 µM 1.52004609340673 0.0409970278355599 no 198 0.064249695710628 413 4647384
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.51712866812078 0.0412829506324519 no 199 0.0646171007424299 360 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1361 1608-0041 5.61 µM 1.51043923105534 0.0419446543764007 no 200 0.0654656922760072 426 X1361
SGTC_2081 5214970 32.255 µM 1.50676552343826 0.042311685939624 no 201 0.0659353848106067 403 2063512
SGTC_973 1325-0077 65.9 µM 1.49916273660791 0.0430795152740358 no 202 0.0669157097210203 449 2835149
SGTC_1800 st050079 29.0735 µM 1.49806584463274 0.0431912172239208 no 203 0.0670580720066366 604 3645560
SGTC_228 caffeine 993.056 µM 1.49496377136223 0.0435083833946846 no 204 0.0674619487102831 374 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1558 st069300 45.6 µM 1.49118692813448 0.0438970751890066 no 205 0.0679562123271205 329 24208000
SGTC_130 0136-0219 337.655 µM 1.48998083278394 0.0440217882094786 no 206 0.0681146378865094 421 234244
SGTC_840 0245-0196 390 µM 1.48575946313786 0.0444605390851208 no 207 0.068671377969949 475 3827528
SGTC_2402 5553605 200 µM 1.48451406540657 0.044590651259458 no 208 0.0688362972530993 440 6758546
SGTC_1482 3346-2049 8.48 µM 1.48437127516371 0.0446055887626332 no 209 0.0688552254586611 417 3826804
SGTC_199 4063-0024 41.6 µM 1.4818678067828 0.0448681357846008 no 210 0.0691877362768248 407 306215
SGTC_2707 st078556 66.6 µM 1.48023145143437 0.0450404171611232 no 211 0.0694057448301006 398 17250899
SGTC_2877 9040724 71.43 µM 1.47915376767328 0.0451541700790946 no 212 0.0695496113272393 418 6463895
SGTC_3292 9120825 59.784 µM 1.47832384608047 0.0452419283854694 no 213 0.0696605589808736 416 24824900
SGTC_1736 st036774 51 µM 1.47218090823743 0.045895774783096 no 214 0.0704860157651621 454 1272247
SGTC_2458 5808907 16.39 µM 1.46678887163429 0.0464759341390804 no 215 0.0712167489489074 433 2731747
SGTC_1115 galangin 695.678 nM 1.45494544033194 0.0477709013601666 no 216 0.072842183286602 482 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2313 7726885 200 µM 1.44805376633881 0.0485376390310397 no 217 0.0738010071607495 448 726423
SGTC_1383 3049-0032 20.7 µM 1.44546207843906 0.0488285125312682 no 218 0.0741640686351524 463 712864
SGTC_833 3852-0053 558 µM 1.44458146242081 0.0489276633965045 no 219 0.0742877414176356 510 3123681
SGTC_2711 st079103 59.1 µM 1.44399816275386 0.048993427155434 no 220 0.0743697460726064 407 54693780
SGTC_383 2324-0395 7.37 µM 1.43845330388871 0.0496221109995116 no 221 0.0751527388614492 476 3146421
SGTC_2129 girgensonine 121.053 µM 1.43325087122612 0.050217807652669 no 222 0.0758930782174703 512 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1354 1498-1681 81 µM 1.43089638935025 0.0504892710789564 no 223 0.0762299560130633 504 5754243
SGTC_1952 st077036 64.1 µM 1.42516606803095 0.0511548430553575 no 224 0.0770546011679006 492 2937007
SGTC_3318 9139014 38.6185 µM 1.42515947807335 0.051155612473007 no 225 0.0770555534098927 426 16643984
SGTC_136 0097-0015 404.482 µM 1.41937693030371 0.0518343171435967 no 226 0.0778945772531169 512 4861337
SGTC_1200 1643-0193 18.4 µM 1.41840897370656 0.0519486234572185 no 227 0.0780356986019607 491 5403974
SGTC_2641 levomentholum 100 µM 1.41328194074324 0.0525574202250291 no 228 0.0787864208862879 398 16666
SGTC_2295 7971645 200 µM 1.41078140388849 0.0528563876736174 no 229 0.0791545396941837 480 2978226 YKL099C UTP11
SGTC_3150 9097574 49.47 µM 1.40604907813779 0.0534258818964371 no 230 0.0798547758907361 419 17217476
SGTC_1089 terbinafine 2.25 µM 1.40430385265574 0.053637127753561 no 231 0.0801141937669954 454 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_255 tunicamycin 200.472 nM 1.40354058391196 0.0537297231632686 no 232 0.0802278493736861 497 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_996 3970-0799 1.8 µM 1.40283489551947 0.0538154458458751 no 233 0.0803330392791577 631 6615648 YGL040C HEM2
SGTC_352 k048-0007 5.11 µM 1.39961502390762 0.0542079512544119 no 234 0.0808143162631986 538 6811911
SGTC_2768 sulfasalazine 50.2 µM 1.39960414759678 0.0542092809156498 no 235 0.0808159456358707 472 5384001 An antioxidant and salicylic acid derivative.
SGTC_2997 9067075 71.4286 µM 1.39733809569127 0.0544868757850702 no 236 0.0811559625214338 525 27209819
SGTC_285 1486-1325 46 µM 1.39700552610384 0.0545277105164463 no 237 0.0812059546747932 502 22310230
SGTC_1524 corynanthine 62.1 µM 1.39587597060034 0.0546665843065693 no 238 0.0813759239369827 451 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2329 6138490 200 µM 1.39159067424789 0.0551959867612802 no 239 0.082023192235887 434 720019
SGTC_2717 st081029 62.2815 µM 1.39140231277695 0.0552193493924175 no 240 0.0820517318490291 445 5292846
SGTC_938 3126-1755 342 µM 1.38396334527575 0.0561482718434608 no 241 0.0831848393357232 506 1777771
SGTC_1596 piperlongumine 63 µM 1.38388460976483 0.0561581692394117 no 242 0.0831968949799613 530 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2736 butenafine 14.65 µM 1.38160052106265 0.0564458883802851 no 243 0.0835471969556878 537 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1569 carminic acid 40.6 µM 1.37895572157758 0.0567804951284907 no 244 0.0839542031549325 503 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2119 5528445 120.635 µM 1.37467334011475 0.0573255910434015 no 245 0.0846163700128149 472 791935
SGTC_2669 eugenol 100 µM 1.37000188685754 0.0579248980013641 no 246 0.0853431563221966 415 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1720 st037298 9.481 µM 1.36690460271415 0.0583249602565657 no 247 0.0858276045640872 473 597396
SGTC_1717 st033143 58.0435 µM 1.36680926948341 0.0583373083625342 no 248 0.0858425482814961 552 674616
SGTC_3232 9132874 49.47 µM 1.36588397504747 0.0584572645037471 no 249 0.0859876916420723 470 3784940
SGTC_1326 1431-2094 10.8 µM 1.36501036298211 0.0585706981759142 no 250 0.0861248964728713 527 616278
SGTC_2396 5342950 42.78 µM 1.36484875579712 0.05859170089937 no 251 0.086150295572441 554 1886677
SGTC_2847 9005661 71.43 µM 1.36475504391225 0.0586038825511712 no 252 0.0861650264289337 349 2991449
SGTC_2843 9000894 45.46 µM 1.36420347828712 0.0586756211205791 no 253 0.0862517668919379 351 2242070
SGTC_1634 st006576 41 µM 1.36398083541388 0.0587045983587753 no 254 0.0862867987117118 491 3915356
SGTC_156 3474-0145 5.642 µM 1.36367569765954 0.0587443306505078 no 255 0.0863348280014659 494 2265471
SGTC_2567 aureobasidin a 60 nM 1.35860795091389 0.0594072977304729 no 256 0.0871354271758284 534 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3317 9138495 8.753 µM 1.35488870008017 0.0598975745730458 no 257 0.0877265101951801 534 17020139
SGTC_73 0327-0325 16.231 µM 1.35185580813304 0.060299715763592 no 258 0.0882107234591699 584 53298
SGTC_1142 3253-1408 9.78 µM 1.35094391519082 0.060421038975229 no 259 0.0883566996158032 490 256655
SGTC_39 0986-0283 58.349 µM 1.3502688997549 0.0605109696793555 no 260 0.0884648722274355 585 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1270 0831-1170 17.3 µM 1.3467361563443 0.0609833380667971 no 261 0.0890326115513201 565 6764716
SGTC_1968 st069590 43.6 µM 1.3461851888322 0.0610572679005874 no 262 0.0891214002301635 505 6384066
SGTC_891 0929-0073 133 µM 1.34153806195528 0.0616836182644134 no 263 0.0898729102856087 508 5603632
SGTC_435 c-PAF 6.7 µM 1.33863540276981 0.0620773834859419 no 264 0.0903446975049137 536 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_930 2810-3379 265 µM 1.33712248040475 0.0622833976337196 no 265 0.0905913301373773 586 1015764
SGTC_2879 9041815 71.43 µM 1.33500161259285 0.0625730927347914 no 266 0.0909379093315152 391 4942971
SGTC_658 3253-0951 102 µM 1.33297004302234 0.0628515742775895 no 267 0.0912708174286051 638 1184878
SGTC_1014 4130-3005 69.3 µM 1.32911083340699 0.0633832417956587 no 268 0.0919057033301955 553 743608
SGTC_801 0866-0028 10.1 µM 1.32887980229222 0.0634151807320418 no 269 0.0919438142019179 556 6849771
SGTC_183 3914-0051 30.55 µM 1.32695618045486 0.0636815987605717 no 270 0.0922615891908212 519 1596232
SGTC_3230 9131665 49.47 µM 1.32602392073235 0.0638110278710634 no 271 0.0924158870701144 383 15943720
SGTC_1846 st056244 14.8 µM 1.3250214590134 0.0639504315944354 no 272 0.0925820170130129 557 5393182
SGTC_2563 tomatine 8.54 µM 1.32466615645916 0.063999897267356 no 273 0.0926409514509883 609 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2033 5192550 145 µM 1.32165041634213 0.0644209511858734 no 274 0.0931422933909499 501 182073
SGTC_2237 6667747 47.222 µM 1.3198126960981 0.0646785848948622 no 275 0.0934487808182607 500 729940 YDL015C TSC13
SGTC_2647 atorvastatin 60.16 µM 1.31817136662194 0.0649093620308423 no 276 0.0937231441919245 515 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2478 5763493 32.33 µM 1.31517340179474 0.0653325367642488 no 277 0.0942258160584384 548 1365576 YLR208W SEC13
SGTC_2160 5660466 132.927 µM 1.31381451531141 0.06552505252503 no 278 0.0944543158322317 522 2859134
SGTC_2426 5582046 32.21 µM 1.31226559682352 0.0657450266179689 no 279 0.0947152678789459 554 2251934
SGTC_2076 5212012 200 µM 1.31196574526804 0.0657876769549982 no 280 0.0947658463109043 422 604802
SGTC_2829 7992743 58.44 µM 1.30712540566873 0.0664791290814151 no 281 0.0955850620935065 549 16462845
SGTC_587 k089-0003 57 µM 1.30114026275721 0.0673418825691967 no 282 0.096605224161748 388 9659696
SGTC_1906 st060206 94.7 µM 1.29996953373064 0.0675116498066868 no 283 0.0968057056506865 572 5133468
SGTC_518 1021-0119 62.6 µM 1.29764068597598 0.067850338744441 no 284 0.0972054172013681 546 1097762
SGTC_822 1487-0950 154 µM 1.29758648413712 0.0678582370224774 no 285 0.097214734528452 539 1958375
SGTC_3018 9082602 49.47 µM 1.29672818570237 0.0679834027180546 no 286 0.0973623638838258 565 17332089
SGTC_595 3909-8003 73.7 µM 1.29494757342711 0.0682436379150937 no 287 0.0976691577911382 546 699517
SGTC_323 4013-0906 34.3 µM 1.29265727455666 0.0685794930299535 no 288 0.0980648105112475 530 2910086
SGTC_2883 9059145 45.46 µM 1.28859794054086 0.0691778943013292 no 289 0.0987689498893431 513 16476510
SGTC_916 4466-0038 42 nM 1.28795682423796 0.0692727703683466 no 290 0.0988804965574462 696 5722064 YGL116W CDC20
SGTC_1888 azatryptophan 97.5 µM 1.28680966477023 0.0694427837164698 no 291 0.0990803187295342 502 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3244 9134489 49.47 µM 1.28634815578122 0.0695112716607473 no 292 0.0991607916195723 546 16584271
SGTC_1707 st032323 6.317 µM 1.28251439862356 0.0700822135732517 no 293 0.0998311286351373 591 3132057 YMR211W DML1
SGTC_332 4112-0506 40.9 µM 1.28053580331965 0.0703782836358103 no 294 0.100178380623902 568 2790355
SGTC_1271 0832-2808 169 µM 1.27997131070017 0.0704629284139387 no 295 0.100277612986725 582 3663794
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.27939482355066 0.0705494525065437 no 296 0.100379027899428 480 77254
SGTC_2533 agelasine 13.65 µM 1.27506199881241 0.0712023753521106 no 297 0.101143649235877 600 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_470 aa-861 153 µM 1.27437279627568 0.0713066591036617 no 298 0.101265664291359 610 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1035 k081-0041 55.2 µM 1.2734331497711 0.0714490265625709 no 299 0.101432190189705 600 731709
SGTC_557 1315-0110 16.2 µM 1.27014654064384 0.0719487026098469 no 300 0.102016218052154 564 6833801
SGTC_3119 9125183 49.47 µM 1.26735168138917 0.0723757203771765 no 301 0.102514784332482 434 22695334
SGTC_1464 k208-0027 110 µM 1.26063417894812 0.0734100069244291 no 302 0.103720339223815 597 X1464
SGTC_2576 guaiol 23.12 µM 1.25834418240279 0.0737651670500392 no 303 0.104133654501 621 227829
SGTC_553 k007-0256 45.7 µM 1.25825231064851 0.07377944297747 no 304 0.104150261061991 579 6287000
SGTC_1322 1348-1070 12 µM 1.25119747969864 0.0748820104873452 no 305 0.105431218760102 537 6758089
SGTC_2032 5185112 25.99 µM 1.24954515460321 0.0751420524925039 no 306 0.105732874381204 538 5718189
SGTC_2308 7584454 197.62 µM 1.24498134631376 0.0758638795606372 no 307 0.106569303554224 635 893577
SGTC_1441 4106-0040 13 µM 1.24460062655276 0.0759243332785948 no 308 0.106639294979552 561 2904180
SGTC_1103 duloxetine 36.1 µM 1.24389196507121 0.0760369578756538 no 309 0.106769663473494 661 60835 A selective serotonin reuptake inhibitor.
SGTC_844 0330-0132 15.3 µM 1.24058059042327 0.0765649070820482 no 310 0.107380362907679 590 2828079
SGTC_2167 5876490 200 µM 1.23904382418569 0.0768108667281505 no 311 0.107664634475751 586 686534
SGTC_2716 st080858 38.6235 µM 1.23674170953141 0.0771804438678484 no 312 0.108091494320816 587 5296050
SGTC_1552 6-methylflavone 10.6 µM 1.23517906169904 0.0774320771881102 no 313 0.108381935034839 534 689013
SGTC_959 1222-0044 107 µM 1.23502728215799 0.0774565514217109 no 314 0.108410175351472 587 6083612
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.23441514715312 0.077555316942536 no 315 0.108524123794324 622 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_477 mead ethanolamide 10 µM 1.23229544466017 0.0778980613747751 no 316 0.108919370422701 418 16061185
SGTC_2176 5809774 33.9695 µM 1.23202308872878 0.0779421830608238 no 317 0.108970229723956 628 2870539
SGTC_2375 9072683 200 µM 1.23132200817505 0.0780558454060965 no 318 0.109101226883108 662 16798029
SGTC_859 0439-0102 54.6 µM 1.23062017337137 0.0781697559416955 no 319 0.109232478289679 655 610143
SGTC_2412 st077135 33.4 µM 1.22927323647329 0.078388722208729 no 320 0.109484689125079 613 13258915
SGTC_154 3389-1638 511.116 µM 1.22878983464485 0.0784674202549965 no 321 0.109575306907233 518 5238686
SGTC_1300 1094-0077 113 µM 1.22842308114695 0.0785271678477356 no 322 0.1096440938891 553 5532636
SGTC_1219 1469-0211 33.1 µM 1.22673468689782 0.0788026680299728 no 323 0.109961163003483 572 6822282
SGTC_1203 3992-3522 103 µM 1.22562923911066 0.0789834434554635 no 324 0.110169114769436 635 5322312
SGTC_500 h-89 112 µM 1.22153831482735 0.079655170740142 no 325 0.110941133948825 645 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_797 k781-0471 270 µM 1.21673034550691 0.0804501507299738 no 326 0.111853414690001 627 23738129
SGTC_2955 9076254 12.21 µM 1.21526876416992 0.0806930019776768 no 327 0.112131800591722 562 16459619
SGTC_167 3672-0051 66.205 µM 1.21325966452468 0.0810277299519947 no 328 0.112515279537256 572 3237971
SGTC_3176 9106582 49.47 µM 1.20667458064925 0.0821321916982117 no 329 0.11377874606876 437 17018027
SGTC_326 k292-0812 17.5 µM 1.20630035510908 0.0821952963440434 no 330 0.11385085040097 597 3579357
SGTC_753 1322-0200 289 µM 1.20170793169371 0.0829726808694906 no 331 0.114738353500857 620 5403907
SGTC_3166 9102297 49.47 µM 1.20167959670839 0.0829774943939015 no 332 0.114743844579922 644 25237072
SGTC_1400 3771-8998 51.5 µM 1.20123557874833 0.0830529512439777 no 333 0.1148299159051 566 670767
SGTC_2536 dehydroabietamide 32.04 µM 1.2000790267793 0.0832497390942845 no 334 0.115054325050833 671 3983547
SGTC_462 ag-879 158 µM 1.19864644159467 0.0834939799200182 no 335 0.115332725887226 663 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1132 3456-3614 2.5 µM 1.19746404555727 0.0836959714386814 no 336 0.115562866736053 726 3125502
SGTC_1301 naphtanilide LB 4.81 µM 1.19669905612844 0.0838268518505801 no 337 0.115711937537842 657 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1673 st016611 27.3 µM 1.19269655531502 0.0845141383661219 no 338 0.116494117603182 639 5226799
SGTC_1974 st069448 26.9 µM 1.19149697884591 0.084720943863128 no 339 0.116729270980824 599 6323587 YNR016C ACC1
SGTC_2819 7996655 46.38 µM 1.18716255553164 0.0854713564631414 no 340 0.117581753747507 547 6456960
SGTC_895 0964-0006 13.7 µM 1.185907849503 0.085689508289753 no 341 0.117829346478902 633 6738897
SGTC_1779 st039427 55 µM 1.18589037210922 0.0856925499706878 no 342 0.117832797918361 727 1124498
SGTC_298 1391-0729 10 µM 1.18578510993126 0.0857108709995973 no 343 0.11785358662863 599 3237558
SGTC_1231 0242-0792 125 µM 1.18199677212154 0.0863721899296503 no 344 0.118603490821899 621 3707635
SGTC_3291 9121177 71.43 µM 1.18014128784807 0.0866974850636068 no 345 0.118972012855121 529 17015612
SGTC_432 NS 1619 61.3 µM 1.17847553913429 0.08699029578436 no 346 0.119303539215248 581 4552 A K+/calcium channel activator.
SGTC_2384 9036245 200 µM 1.17796571990071 0.0870800609419886 no 347 0.119405136393742 650 6462766
SGTC_2149 5554786 194.827 µM 1.17734454449138 0.0871895263358569 no 348 0.119529007204348 675 745063 YPR165W RHO1
SGTC_2976 9009005 19.48 µM 1.1751501516341 0.0875770515012473 no 349 0.119967324609173 634 2993148
SGTC_858 0438-0351 2.77 µM 1.17327762464647 0.0879087509299118 no 350 0.120342246053598 688 2799119
SGTC_186 3455-3465 67.277 µM 1.17119502671163 0.0882787618145666 no 351 0.12076019694179 542 755278
SGTC_1962 st076595 64.5 µM 1.17001360974213 0.0884891770662353 no 352 0.120997745978391 642 279619
SGTC_24 0417-1663 219 µM 1.16996773107655 0.0884973557768435 no 353 0.121006977487995 625 4329390
SGTC_3207 9114163 49.47 µM 1.16618448183646 0.0891737287004853 no 354 0.121769932673972 704 849233
SGTC_746 1095-0025 46.6 µM 1.16403706869557 0.0895593527344446 no 355 0.122204494915287 699 6749286
SGTC_446 go6976 132 µM 1.16226615330124 0.0898782986912825 no 356 0.122563685290731 623 3501 A protein kinase C inhibitor.
SGTC_2745 rifampicin 24.3 µM 1.157346591246 0.0907687522183303 no 357 0.123565392664285 504 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1169 aniline yellow 25.8 µM 1.15698875304257 0.0908337763730013 no 358 0.123638477719029 621 6051 A DNA damaging agent.
SGTC_1691 st019933 84.6 µM 1.15390253553169 0.0913960199220066 no 359 0.124270064779246 631 6176082
SGTC_2413 inermin 26.06 µM 1.15369177671598 0.0914345096131575 no 360 0.124313278236396 681 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1958 st076513 41.9 µM 1.15328370429737 0.0915090677220741 no 361 0.124396978250047 650 732122 YGL099W LSG1
SGTC_636 0kpi-0074 126 µM 1.15175635643411 0.0917885263838869 no 362 0.124710603366523 631 616434
SGTC_1941 st076221 61.8 µM 1.1516082096722 0.0918156663774234 no 363 0.124741053148788 717 2828568
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.14946923814376 0.0922081815472294 no 364 0.125181272113065 696 165521
SGTC_367 0335-0881 7.1 µM 1.1448809982906 0.0930543407638933 no 365 0.126129228146845 680 23828853
SGTC_2630 antimycin a 100 µM 1.14388168245788 0.0932393924705233 no 366 0.126336354297508 700 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1851 st056236 18.9 µM 1.1429954224935 0.0934037360604311 no 367 0.126520245802387 691 5393171
SGTC_161 4065-0411 162.148 µM 1.14299431825131 0.0934039409589311 no 368 0.126520475039617 715 1906281 YLR208W SEC13
SGTC_502 l-744,832 89.3 µM 1.14268187870545 0.0934619292552033 no 369 0.126585348136479 688 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2103 5378138 10 µM 1.14077329427737 0.0938167370130578 no 370 0.126982138337905 752 244142
SGTC_1830 st055982 50.3 µM 1.13978376086456 0.0940010831781444 no 371 0.127188200411322 676 455313 An antimicrobial agent.
SGTC_790 1575-0012 79.1 µM 1.13788976405194 0.094354672489968 no 372 0.127583257987313 702 378741 YLR208W SEC13
SGTC_2239 6685329 187.64 µM 1.13474323094447 0.0949442639240086 no 373 0.128241459095779 666 805680
SGTC_223 busulfan 5 mM 1.13076523481157 0.0956935323266086 no 374 0.129076958023568 589 2478 A DNA alkylator.
SGTC_1754 st042065 16.137 µM 1.12940591009959 0.0959505602154667 no 375 0.129363320413875 785 1126236 YIL048W NEO1
SGTC_2916 7875993 68.79 µM 1.12877500708358 0.0960700268578334 no 376 0.129496379194659 685 1299250
SGTC_2953 9074162 66.49 µM 1.1273062297195 0.0963485754713915 no 377 0.129806514689304 625 16451992
SGTC_2859 9028643 45.46 µM 1.12365659986517 0.0970432841812619 no 378 0.1305793673621 641 17151580
SGTC_1242 0402-0103 60.1 µM 1.12261121056034 0.097242950285881 no 379 0.130801326040166 636 432868
SGTC_3339 9145883 14.936 µM 1.11882401625354 0.0979688166910558 no 380 0.131607611921239 659 2030670
SGTC_2337 9009472 200 µM 1.1180253315013 0.0981224009806594 no 381 0.131778087305575 732 5742383
SGTC_291 SEC14.278 35.5 µM 1.11785938155858 0.0981543346969789 no 382 0.13181352762376 716 1068044
SGTC_2362 9071156 126 µM 1.11527444591901 0.098652736699195 no 383 0.132366416253319 699 653133
SGTC_3152 9099253 49.47 µM 1.11303589069057 0.0990858475900005 no 384 0.132846507698769 784 25236131
SGTC_2289 7946404 165.07 µM 1.11114253868991 0.0994532535293811 no 385 0.13325350004256 753 1246120 YPR165W RHO1
SGTC_662 k832-1615 104 µM 1.11006065928811 0.0996636393359971 no 386 0.133486444144033 685 5878478
SGTC_1376 2910-0861 41.3 µM 1.10980648388443 0.0997131142560682 no 387 0.133541212347404 709 1112859
SGTC_386 1509-0011 3.07 µM 1.10904058105984 0.0998623047643727 no 388 0.133706337962205 783 3107280
SGTC_2794 7785382 27.27 µM 1.10869525565998 0.0999296241349173 no 389 0.133780834645009 787 2205081
SGTC_2709 st078560 56 µM 1.10809701587289 0.100046326267718 no 390 0.133909959800114 708 17250903
SGTC_2034 5197015 53.07 µM 1.10777004832198 0.100110151782644 no 391 0.133980569254145 707 780676
SGTC_1276 0871-0068 94.2 µM 1.10775281081206 0.100113517445715 no 392 0.133984292446994 684 3414906
SGTC_290 2043-6722 48.1 µM 1.10598753503341 0.100458629127307 no 393 0.134365957313934 703 773758 YLR208W SEC13
SGTC_3353 9151644 39.2805 µM 1.10339163321125 0.100967703904842 no 394 0.134928564263318 708 4909158
SGTC_1760 st045453 10.4495 µM 1.09934052941606 0.101765907443887 no 395 0.135809780160291 740 3323419 YIL048W NEO1
SGTC_109 0132-0036 33.701 µM 1.0984617144115 0.101939668231607 no 396 0.136001463368076 573 67274 A color developer.
SGTC_598 3937-0236 20.2 µM 1.09544679921344 0.102537423213783 no 397 0.136660470400045 765 1379313
SGTC_2525 harmine 47.85 µM 1.09369155313237 0.10288660020574 no 398 0.137045140081092 670 5280953 A monoamine oxidase inhibitor
SGTC_1106 tegaserod maleate 11.7 µM 1.09011065173059 0.103601638415474 no 399 0.137832202373234 739 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_297 0986-0032 24 µM 1.08986037690244 0.103651748046874 no 400 0.137887326466407 687 2847425
SGTC_2177 5811945 192 µM 1.08830062854385 0.103964434751073 no 401 0.13823120658136 701 5343475
SGTC_1946 st076057 65.1 µM 1.08792987395413 0.104038861384126 no 402 0.138313033349449 585 953009
SGTC_2944 9067346 25.62 µM 1.0878632657488 0.104052236651805 no 403 0.138327737499445 702 6473075
SGTC_1086 cerivastatin 2.18 µM 1.08769233860102 0.104086565400436 no 404 0.138365475540147 690 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_848 0368-0089 85.6 µM 1.0872427699766 0.104176895279512 no 405 0.138464766759146 744 762535
SGTC_1641 st009299 47.1 µM 1.08672012017036 0.104281980462323 no 406 0.138580259628533 642 4046054
SGTC_672 1441-0018 53.7 µM 1.08578716577969 0.104469753368869 no 407 0.138786582916962 674 251141
SGTC_1386 3228-0095 33.8 µM 1.08515105343548 0.104597922155181 no 408 0.138927379343743 694 870181
SGTC_1094 duloxetine 25.4 µM 1.08302584491246 0.105026951331854 no 409 0.139398475780488 713 60834 A selective serotonin reuptake inhibitor.
SGTC_3179 9107801 49.47 µM 1.0801269545373 0.105614220195307 no 410 0.140042825154693 717 4818259
SGTC_2231 micatex 6.853 µM 1.07980504629495 0.105679579846666 no 411 0.140114501783024 693 20737 An antifungal of unknown mechanism.
SGTC_2753 fluvastatin 17.09 µM 1.07846378855431 0.105952221092335 no 412 0.140413416707338 736 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_919 tnp00227 403.569 nM 1.07811120266907 0.106023976519482 no 413 0.140492066401797 764 1269246 A methoxyflavone. YNL221C POP1
SGTC_547 1120-0019 610 nM 1.07382213607021 0.106899665532596 no 414 0.141451203345478 731 3676939
SGTC_100 0086-0128 49.5915 µM 1.07284405262946 0.107100087175817 no 415 0.141670545857801 766 93297
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.07234757333365 0.107201925680941 no 416 0.141781973157952 745 229346 A bile salt which induces apoptosis.
SGTC_2159 5658611 73.75 µM 1.07008488867251 0.107666934894637 no 417 0.142290550184458 737 793844
SGTC_538 2922-0838 53.3 µM 1.06952892260956 0.107781414759835 no 418 0.142415701723515 807 777039
SGTC_1776 st049249 45.9 µM 1.06880356734287 0.1079309056149 no 419 0.142579095778422 737 1822314
SGTC_558 k064-0027 21.3 µM 1.06767098685106 0.108164621347426 no 420 0.142834475096949 751 5088526
SGTC_1131 3454-3128 32.3 µM 1.06645202517467 0.108416569232163 no 421 0.143109677279552 779 710982
SGTC_882 0843-0131 351 µM 1.0642289414743 0.108877146417529 no 422 0.143612499609599 788 5425421
SGTC_1930 st074634 34.3 µM 1.06280243684048 0.109173428769518 no 423 0.143935777109242 735 684253 YOR116C RPO31
SGTC_1967 st070177 51.4 µM 1.06178271380385 0.109385578141336 no 424 0.144167169527891 714 5729214
SGTC_1734 st037168 69.4 µM 1.06004165747853 0.109748482184963 no 425 0.144562824061791 734 708907
SGTC_2766 oltipraz 83.91 µM 1.05900946651634 0.10996403868853 no 426 0.144797734243074 713 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2860 9025725 38.96 µM 1.05855397222727 0.110059257903429 no 427 0.144901479172208 697 40546248
SGTC_3236 9132701 49.47 µM 1.05653728405512 0.110481549030975 no 428 0.145361408128741 748 24282524
SGTC_3173 9105693 49.47 µM 1.05599230878841 0.11059586504425 no 429 0.145485864375141 765 17096658
SGTC_1525 8-methoxypsoralen 92.5 µM 1.05164533791315 0.11151073761785 no 430 0.146481149275908 825 4114 Related to psoralen; DNA damaging agent.
SGTC_1420 4'-methoxyflavone 42 µM 1.05144373114397 0.111553299221558 no 431 0.146527419915497 762 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2814 7977482 42.97 µM 1.05036815866258 0.111780561888538 no 432 0.146774439632399 816 6456762
SGTC_2585 alliin 100 µM 1.04757633876427 0.112372003240721 no 433 0.147416921802495 762 87310 A garlic compound which reacts with lipids.
SGTC_2385 9074692 200 µM 1.04585783591045 0.112737174491194 no 434 0.147813336906646 753 17046906
SGTC_1801 st050089 28.441 µM 1.04487862261342 0.112945629849887 no 435 0.14803953555637 850 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2493 resveratrol 26.09 µM 1.04346466355976 0.113247119305702 no 436 0.148366569233067 697 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1117 retinoic acid 1.10837 µM 1.04305349120042 0.113334898614301 no 437 0.148461759643742 818 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_80 0159-0065 512.242 µM 1.04263001715827 0.11342535487268 no 438 0.148559840698278 662 1548079
SGTC_1632 st005650 90 µM 1.04229944924816 0.113496001672578 no 439 0.148636433815734 735 2759605
SGTC_548 1436-0017 110 µM 1.0393928843944 0.114118524685763 no 440 0.149311025991945 845 9677137
SGTC_1058 3448-5425 97.3 µM 1.03725382445812 0.114578215809948 no 441 0.149808789717075 729 7279705
SGTC_1059 3448-6867 171 µM 1.03591898223968 0.114865744820897 no 442 0.150119970538296 787 3934407
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.03275106411108 0.11555017739617 no 443 0.150860204969739 710 521171
SGTC_343 4130-2827 29.8 µM 1.03156759486933 0.115806609304901 no 444 0.151137363725989 790 1118244
SGTC_164 4100-3994 89.624 µM 1.03115587766948 0.115895914102674 no 445 0.15123386388511 838 4615967
SGTC_3114 9122766 49.47 µM 1.03093995000132 0.115942770106873 no 446 0.15128449037974 702 17176985
SGTC_2092 5303694 80.6725 µM 1.02812188320617 0.116555520160532 no 447 0.15194624903986 789 1963699
SGTC_1988 st071872 53.4 µM 1.02796275085957 0.116590189688657 no 448 0.151983674910312 811 16414116
SGTC_3086 9117350 49.47 µM 1.02698393667351 0.11680360086195 no 449 0.152214014007263 726 2679265
SGTC_384 k007-0144 5.16 µM 1.02676552913458 0.116851258093377 no 450 0.152265442295226 806 6824886
SGTC_279 1273-0055 2.93 µM 1.02347713105844 0.117570463660903 no 451 0.153041153612574 854 2847562
SGTC_1624 st003710 6.25 µM 1.02309215663313 0.117654865884129 no 452 0.153132137519165 833 24207033
SGTC_1090 efavirenz 20.7 µM 1.02239084701303 0.117808731997771 no 453 0.153297975426745 780 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3048 9093155 49.47 µM 1.01592587367393 0.119233844619659 no 454 0.154832343382081 714 25236002
SGTC_697 0508-1955 564 µM 1.01465512579192 0.119515388084052 no 455 0.155135125952654 833 6243113
SGTC_2915 7971052 15.16 µM 1.01162299167669 0.120189073236215 no 456 0.155859174235951 622 5741558
SGTC_1279 0874-0590 65.2 µM 1.01088194241266 0.120354127022814 no 457 0.156036468843355 820 3523074
SGTC_1359 1582-0056 520 nM 1.01022213722629 0.120501219639331 no 458 0.156194437774263 843 3661189
SGTC_1882 5615643 20 µM 1.01001180340331 0.120548136674623 no 459 0.156244817519889 753 2253075
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.00860372952924 0.120862552745607 no 460 0.156582358993432 748 688803
SGTC_180 1486-1293 102.781 µM 1.00823316493711 0.120945393864668 no 461 0.156671269947414 810 4140536
SGTC_1460 k062-0059 9.15 µM 1.00670224947379 0.121288059281126 no 462 0.157038940410124 772 1373085
SGTC_2831 7999036 19.48 µM 1.00549024665466 0.121559826131039 no 463 0.157330421790924 841 2988270
SGTC_3107 9121808 49.47 µM 1.00499457087151 0.121671094514207 no 464 0.157449732055652 752 662681
SGTC_2186 6124449 200 µM 1.00055177286289 0.122671601886555 no 465 0.158521777886444 802 3834182 YLR033W RSC58
SGTC_2002 4023503 131 µM 0.998213992270487 0.123200375552704 no 466 0.159087801437524 915 4736863 YCR052W RSC6
SGTC_2057 5236571 38.335 µM 0.996945970751446 0.123487851721213 no 467 0.159395368041602 828 54684039 YBR257W POP4
SGTC_3021 9087658 49.47 µM 0.996355871613313 0.12362179457901 no 468 0.159538632959757 801 25237042
SGTC_621 3584-0052 32.1 µM 0.992525126413174 0.124493785107915 no 469 0.160470714349993 851 2273927
SGTC_1492 4158-0558 28.5 µM 0.991066996896133 0.12482682567502 no 470 0.16082643349181 802 3967268
SGTC_718 1130-0073 349 µM 0.988839333434443 0.12533683097166 no 471 0.161370878187469 830 6740020
SGTC_2708 st078559 56 µM 0.984234727139899 0.126395624200925 no 472 0.162500057343246 735 17250902
SGTC_1563 conessine 56.1 µM 0.981744440474539 0.126970835589631 no 473 0.163112882890307 936 441082 An anti-amoebic, histamine inhibitor.
SGTC_1399 3562-5772 25 µM 0.980598070159598 0.127236237989822 no 474 0.163395493194203 747 23847490
SGTC_2681 menadione 3.18 µM 0.98009665930893 0.127352443568276 no 475 0.163519204022812 810 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_440 fluspirilene 35.1 µM 0.979852847692605 0.127408975333799 no 476 0.163579380532449 827 3396 An atypical antipsychotic.
SGTC_2978 9011784 42.97 µM 0.978640491569622 0.127690339347346 no 477 0.163878822429409 922 2994934
SGTC_2696 st077691 74.316 µM 0.977943601281046 0.127852269230715 no 478 0.164051109447354 735 757133
SGTC_2344 7990960 76.95 µM 0.977712183744795 0.127906073108708 no 479 0.164108347066992 780 140813
SGTC_2091 4-phenylthiadiazole 200 µM 0.976190972382584 0.128260141772064 no 480 0.164484918031689 835 270010
SGTC_2063 5246145 200 µM 0.975868333673 0.128335324756434 no 481 0.164564858137411 844 711240
SGTC_1060 3448-7350 82 µM 0.971791775432344 0.129287902170633 no 482 0.165577074158234 822 570178
SGTC_3058 9093861 49.47 µM 0.971538834733184 0.129347168369422 no 483 0.165640012138714 798 17217477
SGTC_476 mead acid 10 µM 0.971397495448795 0.129380293587736 no 484 0.165675187628988 782 5312531 An omega 9 fatty acid.
SGTC_1746 st038117 42 µM 0.96986249360338 0.129740425500974 no 485 0.166057518745468 807 2898218
SGTC_2456 5770359 74.46 µM 0.969451442426221 0.12983698131915 no 486 0.166159998152761 864 3118787
SGTC_345 1362-0200 395 µM 0.968531434207942 0.130053271290303 no 487 0.166389513950775 795 1419823
SGTC_802 4112-3352 742 µM 0.966633445547726 0.130500267837063 no 488 0.166863654394599 890 704594
SGTC_2888 9058547 12.99 µM 0.966335184837225 0.13057060789632 no 489 0.166938242680714 730 16476514
SGTC_3064 1327-0027 10 µM 0.966219888793059 0.130597805664716 no 490 0.166967081386775 690 16000455 YPR107C YTH1
SGTC_1031 k035-0009 16 µM 0.966207561542786 0.130600713834064 no 491 0.16697016496063 903 5180959
SGTC_2142 5622915 118.518 µM 0.962859873026747 0.131392137676667 no 492 0.16780892459921 798 5322196
SGTC_2269 7935389 174.42 µM 0.957793271145344 0.132596215391719 no 493 0.169083506461425 805 97605
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.95720548050766 0.132736394329438 no 494 0.169231775694626 918 368090
SGTC_792 4534-1957 155 µM 0.956985355193094 0.132788917057732 no 495 0.169287323424175 845 1717904
SGTC_2376 9072922 81.32 µM 0.956787293867906 0.13283618746603 no 496 0.169337313397585 858 17087968
SGTC_2481 5478948 45.16 µM 0.951938611187995 0.133997015777029 no 497 0.170564058142844 812 77792
SGTC_716 1683-5115 658 µM 0.951487184161151 0.134105446016216 no 498 0.170678560622846 946 723597
SGTC_2555 cholic acid 100 µM 0.946528891545567 0.135300367413907 no 499 0.171939446672432 853 6708657 Influences liver metabolism.
SGTC_2906 7926292 26.41 µM 0.944700581890373 0.135742816258571 no 500 0.172405879944338 843 2966319
SGTC_2518 prenyletin 46.28 µM 0.937964046771251 0.137381596672169 no 501 0.174131443513512 775 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2789 5281112 71.43 µM 0.931976180054571 0.138849547600354 no 502 0.175674417833342 840 765948
SGTC_2682 pyrogallin 40.03 µM 0.930272642615282 0.139269121593354 no 503 0.176114969324355 938 822798 An ATP competetive kinase inhibitor.
SGTC_397 arbidol 50 µM 0.92650763538618 0.140199484551929 no 504 0.177091115475716 933 131410 A RNA synthesis inhibitor.
SGTC_3038 9091290 49.47 µM 0.925863265183988 0.140359135625303 no 505 0.177258521999619 857 25236843
SGTC_615 k087-0205 167 µM 0.921784796321089 0.141372492226126 no 506 0.178320419693366 833 9642773
SGTC_578 3460-0051 92 µM 0.921756064335971 0.141379648662657 no 507 0.178327914737874 994 2876744
SGTC_3254 9136651 49.47 µM 0.917125428493912 0.142536236381795 no 508 0.179538458773916 946 16454030
SGTC_784 4579-0127 173 µM 0.9170171162727 0.142563365747881 no 509 0.179566835508395 951 1948547
SGTC_38 0929-0051 58.268 µM 0.915888439162688 0.142846277498159 no 510 0.179862705499383 946 1379719
SGTC_2810 7959871 45.46 µM 0.913886909815178 0.143348909059671 no 511 0.180388136328109 931 2974535
SGTC_991 3996-0057 64.7 µM 0.913547843158552 0.143434174899701 no 512 0.18047724159628 856 715343
SGTC_1047 2043-3044 82 µM 0.912240472833859 0.143763262704501 no 513 0.18082107133733 921 669592
SGTC_1390 3413-2614 145 µM 0.910489149185015 0.144204899008612 no 514 0.181282300808563 921 3421432
SGTC_1378 2093-0007 380 nM 0.910478157328456 0.144207673741777 no 515 0.181285197953974 870 3618014
SGTC_536 3852-0578 10.6 µM 0.908870071203041 0.144613999375054 no 516 0.181709356773739 930 2869208
SGTC_3234 9132280 49.47 µM 0.907778501806001 0.144890252381744 no 517 0.181997629416008 889 17612295
SGTC_1623 st003709 20.3 µM 0.906391593731089 0.145241761534481 no 518 0.182364310303183 926 16192618
SGTC_1561 5-methoxyflavone 52.9 µM 0.905562806971808 0.145452089594191 no 519 0.182583651175316 879 94525
SGTC_3215 9129942 49.47 µM 0.905468876570221 0.14547594000562 no 520 0.182608520524687 859 17682944
SGTC_1657 st012939 43.4 µM 0.905056443789199 0.145580694326031 no 521 0.182717742737968 867 24207257
SGTC_2683 piperine 63.03 µM 0.903845320010087 0.145888602281276 no 522 0.183038713394871 875 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_817 1391-0715 46 µM 0.903719877485174 0.145920518937994 no 523 0.183071978124276 856 1353946
SGTC_3257 9139206 32.98 µM 0.903497731066112 0.145977051720822 no 524 0.183130895953057 875 4910041
SGTC_394 menadione 8.33 µM 0.901130279296227 0.146580445176118 no 525 0.183759527679403 917 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_884 0851-0618 334 µM 0.900321661549806 0.14678692089424 no 526 0.183974548342045 934 9642473
SGTC_922 1866-0035 480 µM 0.899722127100874 0.146940134346263 no 527 0.184134072471782 992 3156169
SGTC_2910 7948405 25.97 µM 0.897698115395049 0.147458170747568 no 528 0.184673257238117 881 2971328
SGTC_2995 9067767 71.4286 µM 0.895979588254462 0.147898979253257 no 529 0.18513183247373 849 11673567
SGTC_3312 9133330 71.43 µM 0.895289955330015 0.148076120408128 no 530 0.185316054206801 968 17617324
SGTC_69 0096-0274 206.684 µM 0.89528995217202 0.148076121219625 no 531 0.185316055050657 974 6741392
SGTC_1856 st057054 55.7 µM 0.895273539396879 0.148080338782756 no 532 0.185320440783637 954 1266018
SGTC_2839 9003951 25.97 µM 0.893021696970014 0.148659753143255 no 533 0.185922776801854 901 2990634
SGTC_2648 atorvastatin 78.68 µM 0.892271591611866 0.148853096406418 no 534 0.18612368862489 908 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3213 9129884 49.47 µM 0.892238907707064 0.148861524658671 no 535 0.186132445897411 838 17190742
SGTC_208 k072-0098 12.366 µM 0.890692323629267 0.149260709412137 no 536 0.186547127055643 1015 5948901
SGTC_2960 9079389 5.97 µM 0.890310484873395 0.149359374727389 no 537 0.186649596382591 927 16457355
SGTC_525 k781-2675 26.7 µM 0.888364139743493 0.149862977535969 no 538 0.187172454220554 930 3651118 YDL195W SEC31
SGTC_1616 st002734 56.1 µM 0.887480937665117 0.150091872841933 no 539 0.187410012331521 941 4026101
SGTC_2215 7188065 200 µM 0.885448760588796 0.150619427236257 no 540 0.18795732180875 920 940217
SGTC_2213 7173844 200 µM 0.884324671214225 0.150911771355464 no 541 0.188260486971146 958 892728
SGTC_2800 7887935 81.82 µM 0.883305976633168 0.15117703125917 no 542 0.18853548775775 876 2961002
SGTC_3133 9127736 49.47 µM 0.882156129168825 0.151476814761912 no 543 0.188846191223695 931 27243420
SGTC_2692 st077426 47.7 µM 0.881529143715322 0.151640446241041 no 544 0.189015743549439 961 25238571
SGTC_3101 9120531 49.47 µM 0.877568305475904 0.15267686565471 no 545 0.190089017795184 947 24824904
SGTC_405 ebelactone b 50 µM 0.877407953976763 0.152718923033518 no 546 0.190132547215253 922 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1812 st052057 4.327 µM 0.874909099171114 0.153375321634897 no 547 0.190811683860849 985 3645418
SGTC_2490 carminic acid 95.39 µM 0.873865586887775 0.153649983583324 no 548 0.191095728765612 885 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2150 5556613 200 µM 0.872636849964227 0.153973815597362 no 549 0.191430524177989 971 743190
SGTC_669 0108-0021 26.2 µM 0.87179390505278 0.154196233620457 no 550 0.191660410109276 1040 17201
SGTC_2262 9014885 67.46 µM 0.871095570642038 0.154380655826826 no 551 0.191850986207942 909 6457424
SGTC_3089 9117425 49.47 µM 0.867073569865807 0.155445658360939 no 552 0.192950850488727 869 9401657
SGTC_726 3448-4391 34.2 µM 0.86570257064565 0.155809796240654 no 553 0.193326644974614 991 1356692
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.865601760335836 0.155836593674724 no 554 0.193354294961708 928 390807
SGTC_780 0109-0199 192 µM 0.865232637978349 0.155934739848063 no 555 0.193455557464451 996 610414
SGTC_2064 5220758 200 µM 0.864486929648681 0.156133140977855 no 556 0.193660228663185 974 788518
SGTC_1229 0139-0193 12.2 µM 0.860674490499932 0.157150066071979 no 557 0.194708673283456 1018 3090752
SGTC_222 nsc-310342 10.666 µM 0.859340253675358 0.157506985292982 no 558 0.195076410959758 924 432556
SGTC_1119 parthenolide 318.541 nM 0.857488817341851 0.158003141398083 no 559 0.19558739618949 1010 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1293 1000-1278 195 µM 0.855983652552644 0.158407257475285 no 560 0.19600341089908 980 678847
SGTC_702 1488-0190 94 µM 0.855515855733501 0.158532992486718 no 561 0.196132815210235 971 949357
SGTC_1421 4029-0249 71.4 µM 0.854797705875666 0.15872614503531 no 562 0.196331574235782 1049 2894095
SGTC_3027 9089541 49.47 µM 0.853312456628658 0.159126104813354 no 563 0.196743027023457 960 9943819
SGTC_2368 9071271 200 µM 0.851071275296005 0.159730876661561 no 564 0.197364880382497 935 27209959
SGTC_2876 9059903 25.97 µM 0.850124656895351 0.159986768177028 no 565 0.197627892225731 1007 6916095
SGTC_3096 9117468 49.47 µM 0.848474009380575 0.160433615007795 no 566 0.198087020520191 881 41316311
SGTC_2920 7982904 15.77 µM 0.848155962785945 0.16051980701878 no 567 0.198175559260855 915 6456808
SGTC_26 0302-0163 425.158 µM 0.846379933639416 0.161001674655802 no 568 0.198670414501388 996 3100915
SGTC_941 3237-0776 460 µM 0.844606089548449 0.161483890813276 no 569 0.199165403969849 952 760008
SGTC_1903 st060211 78.3 µM 0.841854251748922 0.162233834426838 no 570 0.199934770180963 1027 688960
SGTC_12 0849-0099 9.267 µM 0.841795090093178 0.162249982295267 no 571 0.199951330355747 947 6071388
SGTC_2764 methyldopa 94.69 µM 0.838620699417421 0.16311795010064 no 572 0.200841095611087 988 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1074 carmofur 3.8 µM 0.837854313605766 0.16332795296958 no 573 0.201056265116412 1064 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1320 1313-0481 95.3 µM 0.832893201050675 0.164691629429723 no 574 0.202452482234218 1035 6813365 YLR208W SEC13
SGTC_2309 7664088 163.95 µM 0.832845036429815 0.164704904642347 no 575 0.202466065665023 1024 704922
SGTC_1501 4491-0275 38.4 µM 0.832531552935898 0.164791324422013 no 576 0.202554487883225 1018 5104718
SGTC_2964 9083345 53.42 µM 0.830724270602267 0.165290120899574 no 577 0.203064706072224 950 17741579
SGTC_227 fluconazole 33.516 µM 0.830283423793979 0.16541193940973 no 578 0.203189278909821 1029 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1999 st074831 12.5 µM 0.829631973091029 0.165592060071343 no 579 0.203373446893776 989 17112523
SGTC_2082 5219693 150 µM 0.827108189219785 0.166291062266729 no 580 0.20408787150443 1030 2834649
SGTC_3117 9124945 49.47 µM 0.826450355446189 0.166473572451057 no 581 0.20427433430421 901 17592065
SGTC_1290 0986-0249 10.2 µM 0.824750860213931 0.166945680778911 no 582 0.204756525067594 1004 53329
SGTC_807 1315-0151 48 µM 0.822534137308508 0.167562767884162 no 583 0.205386483056945 1067 4011080
SGTC_2617 dihydrotanshinone i 20.83 µM 0.822104972593854 0.167682407496339 no 584 0.205508577825493 1042 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2774 tamoxifen 10.92 µM 0.821323364571429 0.167900440145308 no 585 0.205731051268205 1035 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1997 st073024 93.8 µM 0.821024245173276 0.167983928947804 no 586 0.205816229088544 1020 686268
SGTC_32 0928-0142 34.1 µM 0.820248454497178 0.168200588494906 no 587 0.206037242234954 1009 2244242
SGTC_2746 daunorubicin 9.88 µM 0.8198505323203 0.168311788244675 no 588 0.206150659919725 898 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_478 N-arachidonylglycine 10 µM 0.819343432371033 0.168453566340916 no 589 0.206295249605714 921 5283389
SGTC_1448 4255-0083 152 µM 0.81857568415394 0.168668364169303 no 590 0.206514272423839 1060 5399660
SGTC_735 3076-0345 636 µM 0.818384192621669 0.168721966397506 no 591 0.206568922485956 1042 2888990
SGTC_2212 7123476 200 µM 0.816311746801064 0.169302784810756 no 592 0.207160928799865 959 1085715
SGTC_1927 st060202 13.8 µM 0.812934430784488 0.170252049355064 no 593 0.208127826320863 1018 688887
SGTC_3006 9075424 71.4286 µM 0.811561621137817 0.170638878764695 no 594 0.208521610412352 989 7465181
SGTC_889 0919-1524 82.7 µM 0.811124838052439 0.170762073114509 no 595 0.208646991681186 975 3905452
SGTC_1497 4476-2978 41.3 µM 0.811092641337693 0.170771156426464 no 596 0.208656235704309 1058 1528379
SGTC_2139 5578692 56.4705 µM 0.809698051312546 0.17116489382778 no 597 0.209056869143527 1002 650991 YMR113W FOL3
SGTC_986 1493-0483 84 µM 0.809479882066227 0.171226542461216 no 598 0.209119585070837 1003 40079
SGTC_505 gw-5074 63.9 µM 0.809150899961152 0.171319530605168 no 599 0.209214176712873 1028 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3205 9113483 49.47 µM 0.809045606166043 0.171349299147598 no 600 0.209244456971407 1030 17018033
SGTC_2557 derrustone 83.84 µM 0.808601610642717 0.171474861424139 no 601 0.209372169022507 1064 629853 An antioxidant.
SGTC_2520 obtusaquinone 4.71 µM 0.807923016554549 0.171666881940043 no 602 0.209567450231444 1051 5967872
SGTC_1404 3909-7820 48.3 µM 0.806459778408656 0.172081398978764 no 603 0.209988895376412 1039 23741373
SGTC_1709 st033179 39.1045 µM 0.803921838468934 0.17280187923394 no 604 0.210721058427833 1055 573381
SGTC_2740 felodipine 17.08 µM 0.80354113319266 0.172910120923331 no 605 0.210831016027805 985 3333 L-type calcium channel blocker
SGTC_57 miconazole 162.5 nM 0.803535623486139 0.172911687753886 no 606 0.21083260762154 998 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1021 4476-0760 85.3 µM 0.801684931435855 0.173438492761325 no 607 0.211367617235434 1037 746768
SGTC_1900 st060200 72.8 µM 0.801565702501624 0.173472466625176 no 608 0.211402111923883 1027 688945
SGTC_951 1171-0579 82.7 µM 0.799757094161404 0.173988342564289 no 609 0.211925773189802 1077 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_418 lividomycin a 100 µM 0.797894363212818 0.174520674605155 no 610 0.212465897374012 1086 72394 An antibiotic.
SGTC_27 0485-0001 32.618 µM 0.79777558514696 0.174554654097833 no 611 0.212500365944298 984 2054479
SGTC_302 1094-0063 18.9 µM 0.797332372587652 0.174681483430731 no 612 0.212629011984938 991 5440289
SGTC_1662 st014054 52 µM 0.796970016645306 0.174785218361307 no 613 0.212734222520808 1062 2838777
SGTC_444 curcumin 90.4 µM 0.79566330247256 0.175159627987694 no 614 0.213113881083572 1000 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1145 3546-0597 10.2 µM 0.795140720936007 0.17530950429585 no 615 0.213265824821177 1022 875334
SGTC_876 0720-0963 56.8 µM 0.795077669527504 0.175327592926346 no 616 0.213284161668533 1066 765861
SGTC_561 1550-0330 72.9 µM 0.794198557049041 0.175579922149766 no 617 0.213539924209771 1024 6812934
SGTC_1924 st058459 75.1 µM 0.793799925714247 0.175694415997892 no 618 0.213655957958198 1044 688683
SGTC_2166 5933061 31.504 µM 0.792917157698112 0.17594813063283 no 619 0.21391304507687 1223 2877375
SGTC_3164 9100705 49.47 µM 0.792732574963632 0.176001210509864 no 620 0.213966823569407 1024 17174235
SGTC_967 1306-0166 352 µM 0.792204061938497 0.176153249409953 no 621 0.21412085025879 1041 4437607
SGTC_2643 anethole 100 µM 0.792149267126065 0.176169017150139 no 622 0.214136823023379 1072 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2296 7971656 126.45 µM 0.790632649474978 0.176605793136877 no 623 0.214579194295352 1051 666570
SGTC_2858 9025781 8.96 µM 0.788711747888368 0.177159982292668 no 624 0.215140250030037 1123 4894980 YPL153C RAD53
SGTC_1516 st013856 110 µM 0.788231696468444 0.177298650765593 no 625 0.215280596037841 995 5281404 A mutagen and neurotoxin.
SGTC_994 3910-0338 138 µM 0.787968498651517 0.177374707618994 no 626 0.215357566095826 1083 3479481
SGTC_421 streptovitacin 30 mM 0.786534794978765 0.177789369770757 no 627 0.21577712134199 1055 91467 include heat shock
SGTC_700 3453-2283 142 µM 0.78522349927096 0.1781691635147 no 628 0.216161269935403 1093 565664
SGTC_496 calpeptin 138 µM 0.784335012749951 0.178426788429383 no 629 0.216421780050714 1035 73364 A calpain inhibitor.
SGTC_846 0335-0850 148 µM 0.783425849223623 0.178690651638533 no 630 0.216688540793817 1056 6819598
SGTC_993 3909-8757 62.7 µM 0.783119882207004 0.178779506555158 no 631 0.216778358360973 972 4288324 YLR208W SEC13
SGTC_1733 st037357 54.9 µM 0.781757350278692 0.179175532799655 no 632 0.217178595133215 1088 1272339 YGL099W LSG1
SGTC_1424 4048-1941 275 µM 0.781395853035835 0.179280696205957 no 633 0.217284854704578 1133 X1424
SGTC_2205 7238770 200 µM 0.778057016962445 0.180253833368902 no 634 0.218267700436852 1089 279867
SGTC_2004 4023728 41.89 µM 0.776518789875012 0.180703278358046 no 635 0.218721365407571 1077 360084 YDR527W RBA50
SGTC_2543 pimpinellin 60.67 µM 0.774144505323915 0.181398383674789 no 636 0.219422670642882 1005 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1365 1672-3266 55.4 µM 0.77266108401976 0.18183352472363 no 637 0.219861491772072 1092 6415873
SGTC_1931 st074438 57.1 µM 0.771917004801905 0.182052035712022 no 638 0.220081792548498 1078 2787313
SGTC_50 0929-0078 56.389 µM 0.771873413118352 0.182064842209008 no 639 0.22009470273625 995 1377751
SGTC_1214 0358-0031 63.7 µM 0.771151428897532 0.182277030831096 no 640 0.220308589992012 1055 4301366
SGTC_1714 st033236 13.627 µM 0.769934931917631 0.182634904412321 no 641 0.220669245678052 1092 2916566
SGTC_2093 5331342 194.4 µM 0.767107584632515 0.183468357336766 no 642 0.221508776393968 1104 33839
SGTC_2172 5754775 163.918 µM 0.766490188086311 0.183650670021887 no 643 0.221692343942591 1026 2263357
SGTC_2102 5377816 72.7585 µM 0.766255441009841 0.183720018726748 no 644 0.221762162963926 1117 1379702
SGTC_1428 4049-0204 61.7 µM 0.765833524272703 0.183844701878638 no 645 0.221887681993638 1127 X1428
SGTC_1872 amphotericin b 148 nM 0.763287384368972 0.184598245210228 no 646 0.222646012062896 1110 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_173 1273-0061 2.693 µM 0.762655533192795 0.184785541889543 no 647 0.222834428126552 1078 2847414 YPL266W DIM1
SGTC_1216 1165-0504 9.65 µM 0.762237349679443 0.184909567003638 no 648 0.222959179100157 1094 6304004
SGTC_1978 st071761 42 µM 0.761193338910945 0.185219426051304 no 649 0.223270798134484 1033 5147680
SGTC_2421 5690543 90.72 µM 0.761066127711923 0.185257203954401 no 650 0.223308785397537 1068 3397993
SGTC_591 4299-0174 154 µM 0.758837716931634 0.185919750831614 no 651 0.223974820165334 1066 5509088
SGTC_2679 rapamycin 1 nM 0.758008624095869 0.186166629711618 no 652 0.224222909955051 1131 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1382 3002-2117 298 µM 0.757670812488261 0.186267278065598 no 653 0.224324038184654 1148 1497314
SGTC_3125 9127534 49.47 µM 0.757039815142279 0.18645536913014 no 654 0.224513004652501 990 1639235
SGTC_3095 9117207 49.47 µM 0.756928840940126 0.186488461074125 no 655 0.22454624773138 1060 17015229
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.754000833696629 0.18736289166289 no 656 0.22542436056914 1037 6857784
SGTC_1940 st075990 51.1 µM 0.753317329792536 0.1875673800388 no 657 0.225629623720415 1207 1084979
SGTC_1977 st070720 65.3 µM 0.751205055172773 0.188200194313342 no 658 0.226264629182082 1068 682188
SGTC_1764 st044502 93.5 µM 0.749614692190983 0.188677517884597 no 659 0.22674339974512 1111 8407
SGTC_1432 4049-0298 68.4 µM 0.748955420476181 0.188875606996782 no 660 0.22694203756668 1124 741646
SGTC_1146 3579-1023 7 µM 0.748369174573184 0.189051861890523 no 661 0.227118755201257 1148 X1146
SGTC_44 0929-0055 61.211 µM 0.747793604688587 0.189225005559779 no 662 0.227292330105609 1079 1379590
SGTC_628 1636-0253 16 µM 0.746027880861522 0.189756781773455 no 663 0.227825286477068 1116 4456143
SGTC_11 0438-0307 1.3 µM 0.745301310269285 0.189975866868413 no 664 0.228044794604389 1120 4011476
SGTC_2397 5161689 200 µM 0.744763710257297 0.190138071118649 no 665 0.228207288356465 1125 2259942
SGTC_184 1494-0393 24.714 µM 0.743783061433796 0.190434170827088 no 666 0.228503864629465 1139 3090647
SGTC_3266 9136860 49.47 µM 0.743000810984378 0.190670568514116 no 667 0.228740594718439 1086 4871271 YPR165W RHO1
SGTC_1971 st069429 63.5 µM 0.742934396868857 0.190690647287574 no 668 0.228760699760924 1120 1246522 YGL099W LSG1
SGTC_1239 0337-0584 35.4 µM 0.740279921588824 0.191494228724324 no 669 0.229565080750739 1166 914301 YML130C ERO1
SGTC_2345 9052315 157.45 µM 0.739095864989568 0.191853342812097 no 670 0.229924393784298 1095 6469265
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.738389821454477 0.192067675773199 no 671 0.230138799023009 1159 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1849 st056239 19.2 µM 0.737547075628698 0.192323699051222 no 672 0.230394863208801 1098 5393181
SGTC_3200 9114385 49.47 µM 0.737391886807361 0.192370867625846 no 673 0.230442033931869 1126 17018030 YLR208W SEC13
SGTC_1793 st048256 72.231 µM 0.736384451189555 0.192677242739052 no 674 0.230748382250119 1084 672022
SGTC_1936 st074407 74.3 µM 0.73492824526822 0.193120621761746 no 675 0.231191597677171 1173 809813
SGTC_1833 st055984 71 µM 0.734036275976437 0.193392511916019 no 676 0.231463314671246 1129 676288
SGTC_1688 st021091 57.6 µM 0.732431158710371 0.193882371823081 no 677 0.231952723245556 1155 3656366
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.732305354246054 0.193920797563066 no 678 0.231991106015748 1077 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3338 9144300 39.5675 µM 0.731995947228563 0.19401532264466 no 679 0.23208552071714 1121 4901274
SGTC_853 0419-0306 21 µM 0.731951866047703 0.194028791906139 no 680 0.232098973708944 1096 762713
SGTC_1885 st057546 99.9 µM 0.731450938569093 0.194181893234108 no 681 0.232251880622515 1168 702008
SGTC_385 1494-0393 12.4 µM 0.731056768657287 0.194302417351013 no 682 0.23237223944027 1121 3090647
SGTC_2013 4024628 200 µM 0.730760891442541 0.194392916735322 no 683 0.23246260761531 1135 5230760
SGTC_2184 6075246 200 µM 0.729128561379668 0.1948926554924 no 684 0.23296151252837 1130 2267320
SGTC_2372 9071633 200 µM 0.727459067704267 0.195404579240423 no 685 0.23347239069646 1185 21321366
SGTC_2113 5491891 107.031 µM 0.726232181227489 0.195781304689406 no 686 0.233848223388272 1183 789979
SGTC_224 benfluorex 43.875 µM 0.72486336861481 0.196202129558991 no 687 0.234267927757195 1162 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2748 diazoxide 86.69 µM 0.720974997084387 0.197400550950868 no 688 0.235462449074518 1089 3019 A potassium channel activatior.
SGTC_1509 1326-1131 80 µM 0.720797793789421 0.197455271419511 no 689 0.23551696650638 1127 768313
SGTC_3218 9131285 49.47 µM 0.720383824408743 0.197583141114634 no 690 0.235644353279701 1167 17156417
SGTC_2592 piperlongumine 83.33 µM 0.719983459886531 0.197706856052336 no 691 0.23576758970435 1123 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1486 3970-0793 4.53 µM 0.719898896058276 0.19773299274806 no 692 0.235793623887993 1177 2844330
SGTC_687 k029-0044 34.9 µM 0.719671678087667 0.19780323083482 no 693 0.235863584039496 1180 5829338
SGTC_2246 7293507 91.5585 µM 0.719025383361318 0.198003097195855 no 694 0.236062639988613 1176 887656
SGTC_217 ketoconazole 989 nM 0.717602489959786 0.198443555996432 no 695 0.236501210962316 1119 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1572 epiandrosterone 68.9 µM 0.717502437449706 0.198474549631425 no 696 0.236532066487926 1137 441302 A steroid.
SGTC_3132 9126706 49.47 µM 0.715369368977188 0.199136012721314 no 697 0.237190417335538 1176 850858
SGTC_3106 9121286 49.47 µM 0.714543806764564 0.199392375041413 no 698 0.237445489018607 1185 15943471
SGTC_1188 1403-0014 4.57 µM 0.713448148983108 0.199732916976965 no 699 0.237784243800918 1205 9614867
SGTC_218 alverine citrate 93.75 µM 0.713367348174951 0.199758044561699 no 700 0.237809236234597 1139 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2754 granisetron 64.02 µM 0.713256583076533 0.199792493586925 no 701 0.237843499240083 1166 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1462 k081-0014 26.5 µM 0.712972902705336 0.199880737241873 no 702 0.237931262529543 983 3270634
SGTC_158 k038-0087 26.446 µM 0.712285612316545 0.20009462789471 no 703 0.238143965805062 1142 X158
SGTC_1773 st048542 73.5835 µM 0.710833019295161 0.200547139720815 no 704 0.238593858285733 1136 3237138
SGTC_1337 1486-1011 40.3 µM 0.710611927864565 0.200616067975176 no 705 0.238662374784736 1197 X1337
SGTC_1091 telmisartan 47.6 µM 0.710032542666186 0.200796766640818 no 706 0.238841978018209 1239 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2161 5662504 8.5105 µM 0.709320545679523 0.201018957999408 no 707 0.239062790697444 1138 2859334
SGTC_3081 9117243 49.47 µM 0.708850637883946 0.201165681864718 no 708 0.239208585004101 1178 45595589
SGTC_2566 crystal violet carbinol 226 nM 0.708009185905595 0.201428576976282 no 709 0.239469776523059 1135 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_512 prima-1 270 µM 0.707483951185925 0.201592780552118 no 710 0.239632891300026 1172 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_325 2810-4341 181 µM 0.703354420566333 0.202886582862958 no 711 0.24091745193942 1194 774970
SGTC_574 1315-0397 40 µM 0.702012424271217 0.20330810240654 no 712 0.241335707648438 1233 6794277
SGTC_2363 9053361 176 µM 0.701996600342246 0.203313075800452 no 713 0.241340641794324 1211 6469797 YMR079W SEC14
SGTC_2805 7950783 58.44 µM 0.701845453171425 0.203360584375175 no 714 0.241387774582846 1179 1178958 YDL195W SEC31
SGTC_2580 diallyl disulphide 81.36 µM 0.700302114781993 0.203846065479203 no 715 0.24186932566996 1182 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1559 coumarin 343 70.1 µM 0.699982983506813 0.203946539306942 no 716 0.241968965721648 1198 108770 A hepatotoxic, DNA x-linker.
SGTC_1740 st038286 13.222 µM 0.699782261872589 0.204009748700569 no 717 0.242031646990901 1196 716786
SGTC_3131 9127911 49.47 µM 0.697718911742329 0.204660196196445 no 718 0.242676499358005 1235 45595681
SGTC_1520 flindersine 88 µM 0.697267408719626 0.204802691700866 no 719 0.242817730121878 1260 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1284 0929-0043 16 µM 0.697036494943078 0.204875591476323 no 720 0.242889977455602 1168 1239883
SGTC_3327 9140648 26.9345 µM 0.696690214627741 0.204984941529873 no 721 0.242998341983668 1179 8029710
SGTC_1911 st060208 74.3 µM 0.696251981275552 0.205123378680687 no 722 0.243135519661439 1203 688783
SGTC_2767 sibutramine 71.45 µM 0.695295143776081 0.205425835002694 no 723 0.243435178492277 1233 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_668 1682-0499 62.6 µM 0.693614783830516 0.205957637281583 no 724 0.243961909954999 1223 682214
SGTC_1148 3909-7663 27.7 µM 0.693599034876769 0.205962625388309 no 725 0.243966849583513 1251 4084526
SGTC_2787 5284540 71.43 µM 0.69355413940844 0.205976845353959 no 726 0.243980931255422 1197 736958
SGTC_2310 7668677 200 µM 0.692008148760838 0.206466869865927 no 727 0.244466105812612 1229 2197143
SGTC_467 ro 31-8220 72.8 µM 0.691930610116447 0.206491465056647 no 728 0.244490453262216 1160 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1260 0700-1617 7.75 µM 0.691922560999032 0.206494018329144 no 729 0.244492980792654 1199 2853078
SGTC_2515 chrysin 20.77 µM 0.690596851883653 0.206914803655403 no 730 0.244909463197049 1198 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2430 5571206 200 µM 0.690504094558259 0.206944264181446 no 731 0.244938617956295 1242 1731771
SGTC_2447 5741742 33.78 µM 0.690323666203615 0.207001576891968 no 732 0.244995334138745 1231 1776504
SGTC_1507 4075-3230 155 µM 0.689929218690652 0.207126905071069 no 733 0.245119350102163 1137 659771
SGTC_2575 plumbagin 510 nM 0.68991325535656 0.207131978061066 no 734 0.245124369752531 1177 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1972 st070201 17.4 µM 0.6879571411961 0.207754167969806 no 735 0.245739885630686 1195 2829099
SGTC_1837 st055472 66.5 µM 0.687607647755168 0.207865449026448 no 736 0.245849945440932 1261 676091
SGTC_3297 9117502 71.43 µM 0.687345049829162 0.207949085123213 no 737 0.245932658182848 1209 7453720
SGTC_1658 st012944 20 µM 0.686303421162413 0.208281034184556 no 738 0.246260896023845 1154 24207260
SGTC_1651 st011928 86.1 µM 0.686026115578929 0.208369459346284 no 739 0.246348320081851 1218 720198
SGTC_3341 9147222 25.867 µM 0.685825733397596 0.208433369519376 no 740 0.246411503426269 1184 1939759
SGTC_2804 7954240 19.48 µM 0.68535644131277 0.208583091426928 no 741 0.246559511858865 1203 828705
SGTC_1868 st057644 42.7 µM 0.684516135196916 0.20885133918372 no 742 0.246824652084873 1232 688665
SGTC_501 nsc-95397 161 µM 0.681154272734589 0.209926565245826 no 743 0.247886939351611 1228 262093
SGTC_3063 1327-0034 4 µM 0.681050900289129 0.209959678376617 no 744 0.247919641786662 1154 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3271 9137798 49.47 µM 0.678163478253716 0.2108858413116 no 745 0.248834023092187 1160 6498326
SGTC_2226 7298446 200 µM 0.678103341664623 0.210905156019503 no 746 0.248853086057534 1221 3283010
SGTC_731 3966-0296 387 µM 0.677820958933527 0.210995865754538 no 747 0.248942610212756 1256 660956
SGTC_664 1222-0054 14.9 µM 0.677733549525289 0.21102394889206 no 748 0.248970325201758 1224 6813991
SGTC_1265 0819-1001 68.8 µM 0.677580848454381 0.211073014373368 no 749 0.249018746223452 1230 3106768
SGTC_641 4092-0595 30 µM 0.677089588321805 0.211230910058954 no 750 0.249174557226119 1235 786260
SGTC_2522 biochanin a 4.94 µM 0.676768883138971 0.211334025084947 no 751 0.249276301967065 1186 5280373 A possible chelator.
SGTC_2551 apiole 73.87 µM 0.676091793007835 0.211551823921706 no 752 0.249491183496955 1112 10659 A possible DNA adduct former.
SGTC_3061 glucosamine 200 µM 0.674490759476595 0.212067349068855 no 753 0.249999679274407 1180 91431 and experimental redox chemotherapeutic
SGTC_1344 1488-0097 29.1 µM 0.67384099501459 0.212276779508778 no 754 0.250206204295638 1221 747966
SGTC_1690 st023502 41.2 µM 0.671594916514278 0.21300166038781 no 755 0.250920807702843 1214 24207482
SGTC_2861 9024595 19.48 µM 0.668809331846736 0.213902660315388 no 756 0.251808556582564 1182 16482810
SGTC_2023 5144124 124 µM 0.667688529895051 0.214265809850368 no 757 0.252166216597913 1232 2830192
SGTC_1411 3909-8223 150 µM 0.66667811786993 0.214593499284034 no 758 0.252488879496843 1247 X1411
SGTC_153 4077-0274 519.67 µM 0.665390362833498 0.215011556500071 no 759 0.252900423654414 1342 3121976
SGTC_1755 st041960 45.185 µM 0.665163098009046 0.215085384892825 no 760 0.252973090182469 1247 2257073
SGTC_1567 st069303 68.4 µM 0.664382020947451 0.215339234827737 no 761 0.253222918509494 1280 5581319
SGTC_3351 9150312 21.596 µM 0.664287737918454 0.215369888552912 no 762 0.253253083809453 1237 4904905
SGTC_3056 9094900 49.47 µM 0.664084052792428 0.215436120225069 no 763 0.253318258115718 1187 25236784
SGTC_2305 7443522 69.23 µM 0.663991831216981 0.215466111519363 no 764 0.253347769685504 1223 5415886
SGTC_2622 2-methoxyxanthone 59.94 µM 0.662172699921848 0.216058204418818 no 765 0.253930274062656 1275 71034 A hepatoprotective.
SGTC_103 0844-0104 51.839 µM 0.660932304662359 0.216462469492489 no 766 0.254327863909981 1285 5375804
SGTC_1353 1498-1206 8.11 µM 0.659771979757678 0.216841034272034 no 767 0.254700083618573 1294 6756808
SGTC_1587 estradiol valerate 56.1 µM 0.659644049614008 0.216882795863887 no 768 0.254741139680486 1247 13791 A steroid.
SGTC_2204 7233102 200 µM 0.658605554839245 0.217221974736083 no 769 0.255074547458929 1195 2172480
SGTC_3177 9107506 49.47 µM 0.654804966269904 0.218465880072527 no 770 0.25629666637208 1200 8897194
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.654344407968891 0.218616895664941 no 771 0.256444970769758 1239 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2114 5491910 81.25 µM 0.654269001445597 0.218641626946373 no 772 0.256469256686438 1302 2849228
SGTC_2884 9058502 51.95 µM 0.654161777795009 0.218676796150142 no 773 0.256503791897842 1255 6471554
SGTC_1652 st011932 78 µM 0.651406063163385 0.219581783193853 no 774 0.257392198873714 1236 1551076
SGTC_940 3232-1287 54.8 µM 0.651358568899364 0.219597399321017 no 775 0.257407524417308 1240 1585493 YIL048W NEO1
SGTC_3025 9087895 49.47 µM 0.651174829438901 0.219657818912879 no 776 0.257466818296777 1273 17173641
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.65110881752606 0.219679528136589 no 777 0.257488122488607 1224 279621
SGTC_2619 obliquin 87.91 µM 0.648310582261946 0.220600911261947 no 778 0.258392045476012 1252 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1600 coumarin 106 71.1 µM 0.647527155585358 0.220859268603447 no 779 0.258645412593589 1323 100336 A hepatotoxic, DNA x-linker.
SGTC_2799 7812892 81.82 µM 0.647477353486244 0.220875698123547 no 780 0.258661523380078 1265 20205235
SGTC_1248 0469-0687 58.6 µM 0.646533015967919 0.221187363821612 no 781 0.25896711121017 1282 4017482
SGTC_480 am 92016 50 µM 0.64646801390896 0.221208826114123 no 782 0.258988152758069 1206 2129 K+ channel blocker.
SGTC_1979 st071809 45.3 µM 0.646323712179933 0.221256475722816 no 783 0.259034867234679 1347 4976333
SGTC_1995 st072814 61.1 µM 0.646207944434868 0.221294707421056 no 784 0.259072347618288 1224 5769371
SGTC_939 1165-0479 45.3 µM 0.646172873990935 0.221306289999156 no 785 0.259083702402446 1224 1377347
SGTC_2506 ethyl hematommate 54.16 µM 0.645675598469989 0.221470560544997 no 786 0.259244733362007 1238 3940691 An allergen.
SGTC_969 1313-0238 134 µM 0.644537136189048 0.221846903795696 no 787 0.259613592221824 1296 5212874
SGTC_3183 9108214 49.47 µM 0.644318508373496 0.22191921771848 no 788 0.259684458072894 1205 4974831
SGTC_1761 st044296 37 µM 0.641889420120619 0.222723574555533 no 789 0.260472492067711 1274 1826700
SGTC_2778 tioconazole 65.09 nM 0.640655185812801 0.223132908871971 no 790 0.26087336817062 1247 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2497 7-hydroxyflavone 100 µM 0.6391302121495 0.223639258067051 no 791 0.261369113574045 1297 5281894
SGTC_1264 0783-0040 158 µM 0.639056640616763 0.223663703121694 no 792 0.261393042773082 1248 2855798
SGTC_2552 juarezic acid 87.02 µM 0.637962529091758 0.224027414507339 no 793 0.261749036145004 1328 1549512
SGTC_3264 9137442 49.47 µM 0.636994232739897 0.224349581704015 no 794 0.262064300115533 1342 17015726
SGTC_943 3253-1379 105 µM 0.636309402309825 0.224577594081973 no 795 0.262287388926374 1307 668464
SGTC_3238 9133470 49.47 µM 0.634144351056752 0.225299306006895 no 796 0.262993310447542 1350 3534688
SGTC_2409 alverine citrate 63.97 µM 0.634034350354515 0.225336009367126 no 797 0.263029202416477 1416 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2880 9042983 58.44 µM 0.632552654105425 0.225830729061899 no 798 0.263512906782815 1301 6464714
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.632242388118178 0.225934400689785 no 799 0.263614251536274 1266 75037 A free radical scavenger.
SGTC_1751 st044839 27.194 µM 0.630815534618214 0.226411512806382 no 800 0.264080572402133 1294 5291326
SGTC_1032 k061-1018 98.7 µM 0.630129933026045 0.22664096690084 no 801 0.264304788477825 1426 4005393
SGTC_2473 5854593 8.94 µM 0.629396270860071 0.226886650998257 no 802 0.26454482937874 1279 2872951
SGTC_468 gf-109203x 121 µM 0.629364185824428 0.226897398857374 no 803 0.264555329549007 1227 2396 A protein kinase C inhibitor.
SGTC_65 0798-0905 34.986 µM 0.628626390056365 0.227144625216316 no 804 0.264796839569805 1484 3602145
SGTC_2970 9090938 41.86 µM 0.628564949918009 0.227165219903761 no 805 0.264816956435434 1297 17217104
SGTC_2050 5263056 171 µM 0.625011956844156 0.228357969350414 no 806 0.265981605293803 1299 763468 YGL055W OLE1
SGTC_783 0848-0141 92.7 µM 0.625003436240001 0.228360833964249 no 807 0.265984401410065 1294 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_3111 9122088 49.47 µM 0.624884467998952 0.228400833010806 no 808 0.266023443510816 1225 16876704
SGTC_515 4092-1064 102 µM 0.622859379210641 0.229082304169536 no 809 0.266688466824729 1364 717353
SGTC_2235 salicylic acid 500 µM 0.622620072521152 0.229162909557847 no 810 0.266767108755784 1304 338 A COX inhibitor and kinase inhibitor.
SGTC_820 1582-0060 59.9 µM 0.622135547196095 0.229326160344396 no 811 0.266926371304814 1292 3848840
SGTC_2642 cholecalciferol 100 µM 0.622108909200714 0.229335137356259 no 812 0.266935128555681 1312 9821465 A vitamin D precursor, similar to steriods.
SGTC_2605 digitonin 300 nM 0.62094883646217 0.229726273236195 no 813 0.267316643625058 1357 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_717 1532-0246 73.2 µM 0.620520586816939 0.229870758369547 no 814 0.267457552299251 1292 9561992
SGTC_2896 9052656 71.43 µM 0.617223095196029 0.230984985941662 no 815 0.268543792171568 1287 6469436
SGTC_985 1493-0307 8.71 µM 0.617031604300546 0.231049783509572 no 816 0.268606940011779 1288 3278274
SGTC_3224 9130643 49.47 µM 0.616643419972653 0.231181170228492 no 817 0.268734974223006 1356 17644395
SGTC_124 0136-0217 7.121 µM 0.616028657942069 0.231389330777787 no 818 0.268937802896823 1429 3976905
SGTC_2827 7993847 71.43 µM 0.614664527904068 0.231851603005827 no 819 0.269388145157767 1317 2985692
SGTC_1375 2910-0797 186 µM 0.613478750591244 0.232253853177771 no 820 0.269779914494519 1334 742508
SGTC_2332 7982454 138.89 µM 0.612722062221235 0.232510746725509 no 821 0.270030066036456 1327 2981748
SGTC_920 mycophenolic acid 780.421 nM 0.61058402513025 0.233237457470281 no 822 0.270737500549774 1324 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1805 st050013 60.3 µM 0.610403774947938 0.233298781394505 no 823 0.27079718406483 1310 4037144
SGTC_2941 9056145 11.23 µM 0.609576102463917 0.233580483325787 no 824 0.271071323019493 1231 2119517
SGTC_2870 9038528 12.99 µM 0.60925250300003 0.233690673079943 no 825 0.271178542193681 1315 6463316
SGTC_2492 derrusnin 100 µM 0.607910729880226 0.234147871303108 no 826 0.27162334136043 1255 1715307 Part of coumarin class of compounds.
SGTC_2747 doxorubicin 7.63 µM 0.607509547229061 0.234284667133025 no 827 0.27175640432967 1239 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_699 0375-0592 111 µM 0.606617711633113 0.23458892491721 no 828 0.272052321660298 1349 762578
SGTC_3202 9113761 49.47 µM 0.605634684008589 0.234924546737007 no 829 0.272378682676237 1418 4798415
SGTC_85 0868-0259 160.055 µM 0.605574005548467 0.234945272053735 no 830 0.272398834039315 1326 83173
SGTC_644 1498-1197 63.3 µM 0.605369874634092 0.23501500236401 no 831 0.272466631507763 1381 6741615
SGTC_1866 st057638 64 µM 0.604693836999357 0.235246015752138 no 832 0.272691221936934 1337 688802
SGTC_99 0109-0120 622.8 µM 0.604470275120106 0.235322438170443 no 833 0.272765512948878 1380 759414
SGTC_200 k038-0079 37.545 µM 0.604381525076189 0.23535278029543 no 834 0.272795007928172 1341 3436683
SGTC_2691 st077356 60.2 µM 0.602706815622739 0.235925739539397 no 835 0.273351873338913 1401 2839272
SGTC_3211 9128781 49.47 µM 0.601785513829066 0.236241267018823 no 836 0.273658459517501 1338 17194361
SGTC_2742 clothiapine 36.27 µM 0.601455785781125 0.236354248739083 no 837 0.27376822608292 1324 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1603 st002045 67.8 µM 0.601330721407893 0.236397109980224 no 838 0.273809865745242 1325 5887985
SGTC_2514 salinomycin 42.74 µM 0.600863965418185 0.236557111306045 no 839 0.273965297858873 1394 23682228 A polyether potassium ionophore.
SGTC_1456 k015-0012 13 µM 0.600369359557371 0.236726724419465 no 840 0.274130051698233 1395 2989616
SGTC_64 000l-0018 272.079 µM 0.599875725887684 0.236896070813819 no 841 0.274294530485633 1338 6811119
SGTC_2125 5246583 200 µM 0.599498373463564 0.237025570566297 no 842 0.2744202972037 1380 835267
SGTC_1315 1237-0019 3.69 µM 0.599087374083163 0.237166661529026 no 843 0.274557310393206 1357 825140
SGTC_3090 9117696 49.47 µM 0.599028475031283 0.237186884618314 no 844 0.274576948094649 1381 7923821
SGTC_390 dec-rvkr-cmk 16.7 µM 0.597006292006709 0.237881778860757 no 845 0.275251589888298 1388 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2275 7947463 200 µM 0.596861921703846 0.237931432307233 no 846 0.275299785975951 1298 1225414
SGTC_1794 st048918 76.9 µM 0.59609353738309 0.238195799202821 no 847 0.27555637062749 1302 672303
SGTC_1818 st052136 56.3 µM 0.595614899829273 0.238360558426926 no 848 0.27571626029097 1264 674169
SGTC_2151 5563267 85.4165 µM 0.594483575061002 0.238750237179403 no 849 0.276094362374416 1344 5310824
SGTC_147 4466-0538 29.23 µM 0.594395704095825 0.238780518442019 no 850 0.276123740537838 1396 6742687 YHR072W ERG7
SGTC_3062 9077494 49.47 µM 0.593883104053562 0.238957207700395 no 851 0.276295150228072 1361 16459633
SGTC_1942 st076330 65.2 µM 0.593389191341988 0.239127523186098 no 852 0.276460360382494 1377 24208414
SGTC_1141 3253-0389 52.6 µM 0.592933910845226 0.239284575905386 no 853 0.276612691240664 1321 5402031
SGTC_824 1304-0008 100 µM 0.592815430111001 0.239325456039206 no 854 0.276652340078851 1358 768245
SGTC_2588 indole-3-carbinol 100 µM 0.592549709762079 0.239417153030826 no 855 0.276741271861297 1384 3712 Induces cell cycle arrest.
SGTC_545 4218-0007 221 µM 0.592270465529438 0.239513537630124 no 856 0.276834744933166 1326 2840508
SGTC_3075 9116269 49.47 µM 0.591988725232671 0.239610805243344 no 857 0.27692906919584 1382 17015205 YNL244C SUI1
SGTC_1183 1254-0324 198 µM 0.591642118825242 0.239730496711908 no 858 0.277045131665802 1399 5799357
SGTC_3231 9132313 49.47 µM 0.59086288778016 0.239999702878374 no 859 0.277306147032752 1370 4905967
SGTC_2199 6590217 200 µM 0.590053864762292 0.240279375801918 no 860 0.277577268861078 1344 703109
SGTC_2788 5282734 71.43 µM 0.588132619933706 0.240944246089172 no 861 0.278221639795513 1463 743706
SGTC_2532 xanthone 78.9 µM 0.586406565285684 0.241542420717894 no 862 0.278801166724512 1367 7020 An insecticide.
SGTC_54 0159-0055 9 µM 0.585499620821727 0.241857050679811 no 863 0.279105910745395 1458 3319099
SGTC_1184 1269-1718 139 µM 0.583408822948328 0.242583220078476 no 864 0.279809059878784 1447 5403821
SGTC_2852 9023854 51.95 µM 0.583311582512456 0.242617022032633 no 865 0.279841783380784 1435 19798528
SGTC_1579 chlormadinone acetate 49.4 µM 0.58284504843554 0.242779230397119 no 866 0.279998807962651 1405 45114258 A steroidal progestin.
SGTC_321 4534-3890 65.3 µM 0.578939927704839 0.244139293632779 no 867 0.281314853854091 1395 699746
SGTC_1010 4112-3296 15.2 µM 0.578918812492556 0.244146658724053 no 868 0.281321977898514 1413 704384
SGTC_1809 st050081 57.6 µM 0.576644128496946 0.244940781061674 no 869 0.28208994126188 1430 5036894
SGTC_684 1140-0066 328 µM 0.575530105162397 0.245330207801936 no 870 0.282466418133751 1350 6813534
SGTC_293 4049-0273 38.5 µM 0.574328867836738 0.245750494360549 no 871 0.282872638943684 1321 1380311
SGTC_2828 7998861 71.43 µM 0.574197441129868 0.245796501128245 no 872 0.282917100357824 1345 2988188
SGTC_1040 k898-0338 155 µM 0.57265909992865 0.246335351025134 no 873 0.283437767722689 1452 20969351
SGTC_2027 5150920 200 µM 0.571834431726845 0.246624476164475 no 874 0.283717074124345 1381 786715
SGTC_815 1582-0027 36.9 µM 0.571081521176302 0.246888602018021 no 875 0.283972192019289 1420 3128206
SGTC_221 trifluoperazine 10.304 µM 0.571031312151074 0.246906221049467 no 876 0.283989208861079 1352 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2499 avocadenofuran 51.48 µM 0.570064656809894 0.247245564742586 no 877 0.284316922754133 1323 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1878 temozolomide 1 mM 0.568975913513396 0.24762806573587 no 878 0.284686242994191 1412 5394 DNA alkylating agent.
SGTC_935 2996-0153 430 µM 0.567281409999129 0.248224012683491 no 879 0.285261502562791 1403 23738523
SGTC_3093 9117344 49.47 µM 0.566118171851159 0.248633559007523 no 880 0.285656725500106 1386 24824913
SGTC_1312 1218-2183 165 µM 0.565863695933269 0.248723201410185 no 881 0.285743221208838 1399 6744073
SGTC_1006 4099-6547 255 µM 0.565613184362294 0.248811464128785 no 882 0.285828381612892 1419 3146833
SGTC_666 0272-0154 136 µM 0.563800241750013 0.249450714723848 no 883 0.286445043633008 1392 6870312
SGTC_2871 9038510 12.99 µM 0.563760728241249 0.249464657052772 no 884 0.28645849095337 1493 4945164
SGTC_1712 st032288 53.4 µM 0.562009000086098 0.250083169676217 no 885 0.287054943563108 1362 2883011
SGTC_41 0478-0632 82.643 µM 0.560494597360107 0.250618540716124 no 886 0.287571061867093 1401 3750424
SGTC_2128 5255449 168.493 µM 0.559943168438388 0.250813632316785 no 887 0.287759101322194 1363 736008
SGTC_1859 st055998 20 µM 0.558935264133465 0.251170429319406 no 888 0.288102950741818 1502 676301
SGTC_2583 asiatic acid 100 µM 0.556068925923858 0.252186575311271 no 889 0.289081868415608 1394 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1185 1319-0113 81.3 µM 0.554127479577982 0.252876067325359 no 890 0.289745802493444 1439 4672763
SGTC_3168 9103419 49.47 µM 0.553510194040399 0.253095499976101 no 891 0.289957051065012 1385 16649256
SGTC_2207 7258803 200 µM 0.552043583405989 0.25361725212297 no 892 0.290459246615629 1408 3666799
SGTC_640 3381-0960 37.1 µM 0.551868095636174 0.253679720367869 no 893 0.290519364248718 1498 1745025
SGTC_3316 9136639 10.545 µM 0.551620531036438 0.25376785948424 no 894 0.29060418346535 1469 4903665
SGTC_2638 epoxomicin 18 µM 0.550511729171978 0.254162817539205 no 895 0.290984217115261 1452 9915668 A protesome inhibitor.
SGTC_2914 7968218 45.32 µM 0.548952056525085 0.254718922101277 no 896 0.291519176086964 1466 2977111
SGTC_117 lucigenin 22.078 µM 0.54869204411844 0.254811691992159 no 897 0.291608403471243 1367 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2010 4012422 159 µM 0.547212261451359 0.255340000593807 no 898 0.292116456653452 1464 952393
SGTC_1636 st007707 68.9 µM 0.546263117745722 0.255679162831431 no 899 0.292442542475815 1485 403051
SGTC_622 1348-1566 26.3 µM 0.54397369041255 0.256498222310668 no 900 0.293229788861171 1489 7340407
SGTC_408 cantharidin 100 µM 0.543856175155889 0.256540301109811 no 901 0.293270224352938 1423 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2371 9071574 200 µM 0.543750041023473 0.256578307749043 no 902 0.293306745966971 1395 45596039
SGTC_2651 TUB2.036 5 µM 0.542723960794389 0.256945898313185 no 903 0.293659937125153 1492 15992207 YFL037W TUB2
SGTC_1221 2958-7315 257 µM 0.542605323101733 0.256988417621652 no 904 0.293700786571134 1430 4562705
SGTC_3300 9124615 50.48 µM 0.542220766140726 0.257126266565746 no 905 0.293833215673798 1490 24824903
SGTC_33 0986-0033 35.816 µM 0.541378432964643 0.257428345050044 no 906 0.294123384721109 1415 2848082
SGTC_1449 4112-4002 201 µM 0.540671838632475 0.257681886851509 no 907 0.294366896196169 1338 2059539
SGTC_3186 9110464 49.47 µM 0.537492158211945 0.258824429388951 no 908 0.295463850102517 1464 17018021
SGTC_872 0588-0139 234 µM 0.536815775365959 0.259067809161517 no 909 0.29569743684988 1416 2047100
SGTC_2179 6298986 200 µM 0.535955201777223 0.259377636432029 no 910 0.295994755922051 1508 738374
SGTC_151 3013-0144 2.285 µM 0.534505678910478 0.259899932089015 no 911 0.296495860749708 1506 906558 YHR107C CDC12
SGTC_365 0121-0052 13.6 µM 0.534125980778021 0.260036835469822 no 912 0.296627187869496 1465 3101739
SGTC_605 1315-0399 119 µM 0.53379808334571 0.260155091582817 no 913 0.296740619988875 1487 24020461
SGTC_3054 9094397 49.47 µM 0.531356746555018 0.261036429690351 no 914 0.297585794367023 1380 2598354
SGTC_2965 9082772 38.63 µM 0.531141320032476 0.261114273672164 no 915 0.29766042630857 1499 16459634
SGTC_2665 lovastatin 100 µM 0.530606729629651 0.261307498471676 no 916 0.297845665644113 1414 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1998 st075797 76.8 µM 0.525827916717378 0.263038031622201 no 917 0.299503888037829 1441 24208315
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.525605690098419 0.263118647982394 no 918 0.299581101209034 1491 6708739 YPR165W RHO1
SGTC_1305 1181-0477 144 µM 0.523231198527994 0.263980821239077 no 919 0.300406686486507 1522 6252086
SGTC_399 oxolinic acid 75 µM 0.520026357433786 0.26514677154251 no 920 0.301522602241584 1420 4628 A DNA gyrase inhibitor.
SGTC_897 1000-0139 31.4 µM 0.519109855738284 0.265480683447882 no 921 0.301842067921456 1525 6151020
SGTC_1498 4478-3555 97.6 µM 0.518869289768127 0.265568364930355 no 922 0.301925947378486 1474 3437919
SGTC_671 0560-0003 407 µM 0.515376621932533 0.26684302498074 no 923 0.303144932793485 1490 3238678
SGTC_3289 9119912 71.43 µM 0.514330587688933 0.267225379107614 no 924 0.303510439891075 1479 17014829
SGTC_1692 fluoroquinolonic acid 71 µM 0.5141274039719 0.267299680370874 no 925 0.3035814595209 1473 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1861 st057647 17.4 µM 0.513535979044513 0.267516014984539 no 926 0.30378822489848 1566 688668
SGTC_83 0170-0301 39.027 µM 0.512691896852655 0.267824920780396 no 927 0.304083429405957 1463 3089716
SGTC_459 nigericin 15.3 µM 0.508036206380988 0.269531970001593 no 928 0.305713976004393 1497 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1453 4237-0541 195 µM 0.508017649388935 0.269538784977608 no 929 0.305720482899726 1505 739892
SGTC_2286 7945697 125 µM 0.507348438747948 0.269784607416755 no 930 0.305955178483538 1402 1245733
SGTC_2785 7756463 72.73 µM 0.506165036911644 0.270219583313621 no 931 0.306370398570515 1415 2201551
SGTC_1759 st043059 70 µM 0.505376604223618 0.270509577313354 no 932 0.306647173991198 1432 669426
SGTC_3190 9110366 49.47 µM 0.505012098903041 0.270643698820586 no 933 0.306775169086408 1532 17123768
SGTC_20 0481-0013 4.944 µM 0.504959268362321 0.270663140830459 no 934 0.306793722348778 1453 182045
SGTC_1841 st054148 70 µM 0.50416424845153 0.270955797933159 no 935 0.307072980694163 1416 675442
SGTC_2346 9031566 143.75 µM 0.503649236296123 0.27114546479121 no 936 0.307253943398956 1545 4771086
SGTC_166 k072-0058 166.424 µM 0.50260705245056 0.271529478999448 no 937 0.307620284954535 1482 5846229
SGTC_725 1497-0963 19 µM 0.502178564942874 0.271687442630498 no 938 0.307770959740368 1607 3549977
SGTC_2218 6965428 192.983 µM 0.501701934555939 0.271863208054305 no 939 0.307938601743655 1524 675684
SGTC_3043 9092303 49.47 µM 0.501683116657351 0.271870148629743 no 940 0.30794522125956 1404 25236084
SGTC_770 0389-1121 67.2 µM 0.501251754266714 0.272029271497962 no 941 0.308096977449113 1575 6753108
SGTC_1643 st009866 20.2 µM 0.500735068565187 0.272219929746394 no 942 0.308278794146358 1494 3156273 YOR207C RET1
SGTC_3282 9108498 15.4605 µM 0.500653632843533 0.272249985777924 no 943 0.308307454881367 1453 16459645
SGTC_1160 4092-0570 10.5 µM 0.498133872466569 0.273180784849802 no 944 0.309194843750477 1448 4994975
SGTC_1244 0416-0015 52.5 µM 0.497788461107237 0.273308502531586 no 945 0.309316574891879 1474 96201
SGTC_730 1436-0052 41.2 µM 0.497612480171927 0.273373583785671 no 946 0.309378602790008 1493 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3148 9097893 49.47 µM 0.497424137337543 0.273443245216762 no 947 0.309444993897299 1361 17174100
SGTC_535 2293-4129 48.2 µM 0.496808210500437 0.273671116369147 no 948 0.309662152374191 1592 396118 YIL048W NEO1
SGTC_2393 9031399 185.94 µM 0.496804539517466 0.27367247478463 no 949 0.30966344685882 1551 1526623 YDL150W RPC53
SGTC_738 1315-0003 72.4 µM 0.495954248298863 0.273987207530846 no 950 0.309963345361698 1549 6251474
SGTC_1016 4226-1401 38 µM 0.495845669492338 0.27402741052713 no 951 0.310001650318896 1476 2901613
SGTC_1397 3532-0190 20.1 µM 0.495152974581957 0.274283960220756 no 952 0.31024607111647 1497 5322280
SGTC_1694 st024011 44.9 µM 0.493731234821214 0.274810893568957 no 953 0.31074800152919 1521 2787533
SGTC_45 0kpi-0036 14.9 µM 0.491907375761475 0.275487592530956 no 954 0.311392411952114 1531 2795021
SGTC_2265 7929201 200 µM 0.491477325913347 0.275647271500799 no 955 0.311544442565567 1431 1265108
SGTC_2158 5657123 3.6195 µM 0.491188016163363 0.275754718790409 no 956 0.311646737021853 1489 2858827
SGTC_1702 st027038 51 µM 0.490855995843294 0.27587805380003 no 957 0.311764151042927 1511 5521182
SGTC_1597 7-benzyloxygramine 47.5 µM 0.488805528371141 0.276640337312052 no 958 0.312489691857004 1473 260807
SGTC_1398 3558-0053 112 µM 0.488337446979664 0.27681449625163 no 959 0.312655420638335 1466 4532369
SGTC_2625 euphol 100 µM 0.487830482651001 0.277003182917598 no 960 0.312834959040329 1616 6708538 A triterpene alcohol.
SGTC_3277 9138724 49.47 µM 0.48696924223183 0.277323871588512 no 961 0.313140063994123 1482 15943418
SGTC_514 4466-0038 2.65 nM 0.486857891485593 0.277365347039146 no 962 0.313179520705285 1533 5722064
SGTC_692 k241-0027 77.8 µM 0.485177216788588 0.277991725669706 no 963 0.313775320944972 1584 3600480
SGTC_1098 clofazimine 15.1 µM 0.484085182802425 0.278399090621165 no 964 0.314162708260377 1550 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_506 n9-isopropylolomoucine 153 µM 0.483934439063297 0.278455345884826 no 965 0.314216199078794 1630 6610355
SGTC_63 0099-0242 26.702 µM 0.482722558800304 0.27890780224629 no 966 0.314646371698709 1505 3898502 YLR359W ADE13
SGTC_1439 4092-1168 46 µM 0.480124073757821 0.279879152494007 no 967 0.315569585573032 1527 2886240
SGTC_961 1252-1571 372 µM 0.47929256165197 0.280190329559645 no 968 0.315865256548633 1624 6813498
SGTC_1698 5-fluorocytosine 1.055 µM 0.479141223851801 0.280246982782728 no 969 0.315919082271676 1554 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1179 1021-1431 9.29 µM 0.479098255314669 0.280263069042547 no 970 0.315934365434563 1528 2840958
SGTC_1713 st033146 12.748 µM 0.478064515635731 0.280650208014422 no 971 0.316302143481687 1626 674619
SGTC_3135 9127742 49.47 µM 0.476588919619244 0.281203271474743 no 972 0.316827437565388 1495 3643468
SGTC_2657 nystatin 74.44 µM 0.476094112088351 0.281388846477554 no 973 0.31700366575718 1554 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3097 9117246 49.47 µM 0.475687285249389 0.281541469037833 no 974 0.317148590286683 1491 16423892
SGTC_945 3381-0768 11.3 µM 0.474031397983315 0.28216309282742 no 975 0.317738758697207 1531 1126236 YIL048W NEO1
SGTC_1177 0983-0204 23.6 µM 0.473021417548646 0.282542565848087 no 976 0.318098949551733 1597 766818
SGTC_2780 5215298 71.43 µM 0.472733854930913 0.282650654635308 no 977 0.318201534936305 1613 2834131
SGTC_2476 5806916 10.51 µM 0.472617877015428 0.28269425393667 no 978 0.318242912964435 1558 2870194
SGTC_3262 9137218 49.47 µM 0.472599280965452 0.282701245006038 no 979 0.318249547782345 1462 17650664
SGTC_450 aminopyrene 156 nM 0.472565163833142 0.28271407134583 no 980 0.318261720463122 1579 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_344 k064-0035 6.43 µM 0.471758749354806 0.283017324348338 no 981 0.318549498892198 1470 5088750
SGTC_25 0118-0223 35.662 µM 0.471057092107445 0.283281310255262 no 982 0.31879998257256 1582 5333628
SGTC_299 1273-0059 1.44 µM 0.470451160866167 0.283509375959813 no 983 0.319016359786949 1527 2848077
SGTC_2219 9098279 200 µM 0.46966048814004 0.283807108541968 no 984 0.31929880069187 1573 902349
SGTC_3235 9132602 49.47 µM 0.469167613077792 0.283992779327937 no 985 0.319474916609642 1545 4912240
SGTC_2474 5321570 43.32 µM 0.468383560329843 0.284288259261849 no 986 0.319755161119079 1595 2841384
SGTC_216 k038-0035 28.382 µM 0.468145380612019 0.284378049313944 no 987 0.319840314248936 1510 4444231 YPR107C YTH1
SGTC_2713 st079149 53.4 µM 0.467835592040415 0.284494855062686 no 988 0.319951082916847 1567 3103253
SGTC_301 4119-0100 24.5 µM 0.465488821466861 0.28538044820456 no 989 0.320790720136931 1560 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2951 9072950 58.06 µM 0.463467273483867 0.286144364189332 no 990 0.321514733775558 1522 16488155
SGTC_683 panaxydol 45 µM 0.461776493858401 0.28678403226767 no 991 0.322120804622229 1598 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_507 nimesulide 162 µM 0.461737543237258 0.286798776334503 no 992 0.322134772306765 1601 4495 A COX2 inhibitor.
SGTC_2835 9006588 71.43 µM 0.461504233969306 0.28688709894061 no 993 0.322218442219414 1520 2345538
SGTC_2954 9074818 52.69 µM 0.46147497855717 0.286898174910365 no 994 0.322228934499169 1578 16648742
SGTC_1324 1418-0026 34.4 µM 0.461264798854108 0.286977753973232 no 995 0.322304318365061 1560 1372513
SGTC_2101 5377231 179.231 µM 0.460835952107506 0.287140158033464 no 996 0.322458152866332 1623 2844213
SGTC_2909 7941780 10.49 µM 0.460738681515894 0.287177000413531 no 997 0.322493049685713 1611 1243215
SGTC_3010 9080089 71.4286 µM 0.458091821933269 0.288180387461028 no 998 0.323443237061498 1616 17027233
SGTC_2712 st079126 47.7 µM 0.456415298237424 0.288816788258135 no 999 0.324045683441155 1508 3152970
SGTC_674 0498-0004 451 µM 0.455526211816596 0.289154549666299 no 1000 0.324365357278614 1506 4231473
SGTC_1677 st019204 53.9 µM 0.453863520412251 0.289786699362716 no 1001 0.324963530608417 1491 3945625
SGTC_1004 4084-0029 199 µM 0.452811055266441 0.290187177901405 no 1002 0.325342401136152 1653 716894 YLR208W SEC13
SGTC_449 xestospongin c 11.1929 µM 0.452627727378486 0.290256963380845 no 1003 0.325408414706293 1609 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1101 ebselen 5.29 µM 0.452056573606266 0.290474428799695 no 1004 0.325614113559628 1685 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3194 9111903 49.47 µM 0.450178547340801 0.291190019853466 no 1005 0.326290851743749 1611 17087251
SGTC_74 000s-0487 160.283 µM 0.45014970567235 0.291201015911873 no 1006 0.326301249174777 1442 677548
SGTC_120 rhodamine 6G 52.259 µM 0.449253902089656 0.291542642859644 no 1007 0.326624253836958 1532 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_3321 9137793 26.8275 µM 0.448883120311677 0.291684100230224 no 1008 0.326757986651535 1543 4904192
SGTC_670 4204-0025 119 µM 0.448442368244338 0.291852293648167 no 1009 0.326916985163434 1624 719039
SGTC_1208 2323-2347 50.3 µM 0.446304691829492 0.29266868296332 no 1010 0.327688583794962 1641 5412760
SGTC_1783 st039459 87.517 µM 0.444976491308366 0.293176463087315 no 1011 0.328168371609404 1714 729761
SGTC_2287 7945887 168.79 µM 0.444527278825933 0.293348292480464 no 1012 0.328330705513603 1625 1245853
SGTC_964 1287-0107 19.4 µM 0.443593845640858 0.293705491504346 no 1013 0.328668128039805 1665 51516812 YPR165W RHO1
SGTC_2270 7924575 90.91 µM 0.442207113476053 0.294236526836452 no 1014 0.329169669503179 1687 1262135
SGTC_1659 st012954 42.1 µM 0.441344826208497 0.29456695467792 no 1015 0.329481689385219 1589 24207262
SGTC_619 1652-1634 108 µM 0.439529312670269 0.295263217257952 no 1016 0.330139023606865 1558 5400454
SGTC_142 0335-0849 62.6745 µM 0.439192004635412 0.295392660724924 no 1017 0.330261208954122 1603 3889043 YPR107C YTH1
SGTC_2044 5102272 200 µM 0.438873180569289 0.295515034881234 no 1018 0.330376715371309 1561 592666
SGTC_3142 9086498 49.47 µM 0.43770804184375 0.295962447916353 no 1019 0.330798969582049 1601 25236367
SGTC_414 piperonyl butoxide 100 µM 0.437009111423293 0.296230986205556 no 1020 0.331052370118219 1533 5794 A potent inhibitor of cytochrome P450.
SGTC_778 3456-2434 196 µM 0.436792240005812 0.29631433377898 no 1021 0.33113101361942 1728 5539063
SGTC_1168 k815-0004 80.5 µM 0.436476610339273 0.296435655127248 no 1022 0.331245482870546 1541 642433
SGTC_2815 7968870 71.43 µM 0.435839214332918 0.296680726017687 no 1023 0.331476695029785 1521 2977326 YHR190W ERG9
SGTC_2164 5685496 200 µM 0.43535459673404 0.296867117563431 no 1024 0.33165253059167 1639 759046
SGTC_968 1309-0633 340 µM 0.434116633432201 0.29734350083407 no 1025 0.332101873673125 1633 3761976
SGTC_3136 9095672 49.47 µM 0.431577433023635 0.298321707050775 no 1026 0.333024281525655 1660 17217380
SGTC_1790 st045711 43.5 µM 0.431397683877961 0.298391009432602 no 1027 0.333089616857064 1700 585119
SGTC_1705 st027868 56.3335 µM 0.429090016356535 0.299281382014287 no 1028 0.333928858739246 1679 292948
SGTC_1297 1068-0111 14.1 µM 0.427473297758631 0.299905881279348 no 1029 0.334517315003222 1540 767057
SGTC_2284 7945075 39.21 µM 0.425513690549139 0.300663619808426 no 1030 0.335231121786769 1730 1245402
SGTC_361 000s-0510 1.45 µM 0.423648991999547 0.301385460479382 no 1031 0.335910910051142 1593 660
SGTC_2463 5473429 200 µM 0.422347861079841 0.301889600957853 no 1032 0.33638556431714 1585 5399405
SGTC_2544 sphondin 68.51 µM 0.421415828582456 0.302250962106275 no 1033 0.336725731419383 1655 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3347 9188721 44.724 µM 0.420226787732264 0.302712250281124 no 1034 0.337159893700781 1624 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1077 5-fluorocytosine 377 nM 0.419244855464797 0.303093428302014 no 1035 0.3375185966784 1597 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_982 1491-0518 27.5 µM 0.41907343704942 0.303159993526378 no 1036 0.337581231520865 1613 3091256
SGTC_1038 k292-0204 154 µM 0.418331998301142 0.303447984394269 no 1037 0.337852198785268 1537 4454212
SGTC_1607 st000305 50.6 µM 0.41737042692682 0.303821661459671 no 1038 0.338203741213999 1642 5457690
SGTC_1531 st059297 52.4 µM 0.415433935026413 0.304574825460022 no 1039 0.338912134384999 1624 7566702
SGTC_1245 0418-0076 17.2 µM 0.415097475132862 0.304705770184223 no 1040 0.339035273854933 1636 6790114
SGTC_1178 0988-0033 191 µM 0.412704518451778 0.305637791166717 no 1041 0.339911556976541 1649 5392207
SGTC_1806 st050005 60.3 µM 0.412630241930464 0.305666740968058 no 1042 0.339938770368037 1578 5194765
SGTC_1588 farnesol 29.9 µM 0.412480894875909 0.30572495371914 no 1043 0.339993490585107 1580 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_22 0964-0034 14.468 µM 0.411097888799855 0.306264257297845 no 1044 0.340500378991707 1582 138402
SGTC_2175 5807670 165.306 µM 0.410815244483098 0.306374526253797 no 1045 0.340604007046272 1642 241186
SGTC_1087 pterostilbene 9.05 µM 0.410640694141396 0.306442632912341 no 1046 0.340668009788165 1712 5281727 Similar to reservatol, lowers cholesterol.
SGTC_373 0844-0104 25.9 µM 0.41058338581115 0.306464995133857 no 1047 0.340689024154933 1730 5375804
SGTC_58 0957-0393 9 µM 0.408834588177572 0.307147737812249 no 1048 0.341330527499685 1581 6997992
SGTC_2866 9034245 58.44 µM 0.407740055201206 0.307575391667847 no 1049 0.341732263518115 1723 6462273
SGTC_354 2783-3500 4.88 µM 0.405649243867965 0.308393036473112 no 1050 0.342500170426799 1552 6740761
SGTC_1697 st025554 27.742 µM 0.404656609916788 0.308781554979661 no 1051 0.342864970315189 1610 1269519
SGTC_2116 5511452 16.8835 µM 0.402600987653334 0.3095868092352 no 1052 0.343620891487644 1648 870744
SGTC_958 1222-0007 33 µM 0.402456017495723 0.309643633352814 no 1053 0.343674225527833 1710 7312461
SGTC_524 r073-0010 27.8 µM 0.401736777226665 0.309925622045766 no 1054 0.343938877636331 1575 2772106
SGTC_280 3448-3607 3.04 µM 0.400680240946734 0.310340055403863 no 1055 0.344327780058769 1708 626179
SGTC_1791 st048313 56.1 µM 0.399394687881845 0.310844647034934 no 1056 0.344801203743958 1729 1204976
SGTC_1198 1612-1005 86.7 µM 0.39886554348522 0.311052444628004 no 1057 0.344996139566351 1712 6998509
SGTC_132 0417-1715 25.805 µM 0.398282413655911 0.311281512349817 no 1058 0.345211011179157 1784 6769098
SGTC_2757 clomiphene 4.22 µM 0.397447940626642 0.311609440991787 no 1059 0.345518584504657 1769 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1068 loratadine 26.9 µM 0.396327002135773 0.312050179179838 no 1060 0.34593190493061 1606 3957 A H1 histamine antagonist.
SGTC_474 dl-dihydrosphingosine 5 µM 0.396204235932029 0.312098465593739 no 1061 0.345977183326638 1684 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_539 4859-0462 2.54 µM 0.396190473543333 0.312103878818916 no 1062 0.345982259281765 1760 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_751 0833-0568 350 µM 0.39596973981333 0.312190706599935 no 1063 0.346063675856501 1667 6954252
SGTC_431 k089-0097 107 µM 0.395940630088307 0.312202157974968 no 1064 0.346074413369781 1590 5499420
SGTC_767 0929-0023 86 µM 0.395500282088054 0.312375407093008 no 1065 0.346236856739058 1624 1204563
SGTC_1729 st035615 45.989 µM 0.395005741470099 0.312570027040391 no 1066 0.346419325370122 1620 17385451
SGTC_3322 9139058 2.11 µM 0.393921190704052 0.312997020700865 no 1067 0.346819612395049 1691 4908926 YPR165W RHO1
SGTC_3345 9148410 3.559 µM 0.392845619354299 0.313420726982441 no 1068 0.347216754221314 1727 4903596
SGTC_1749 st037932 54.2 µM 0.392392821662739 0.313599174014795 no 1069 0.347383994565102 1616 594497
SGTC_1815 st051655 58.2 µM 0.391142483024169 0.314092157460071 no 1070 0.347845960044977 1736 5984156
SGTC_1491 4138-0063 26.5 µM 0.391080726784701 0.314116515315263 no 1071 0.347868783125723 1719 23883227
SGTC_1457 k015-0032 57.3 µM 0.390682246027568 0.314273703296984 no 1072 0.348016061795035 1624 4302660
SGTC_911 3456-4043 236 µM 0.39059678626896 0.314307418841053 no 1073 0.348047650747577 1715 914281
SGTC_3128 9127691 49.47 µM 0.388105974279318 0.315290772483775 no 1074 0.348968805487763 1656 41316314
SGTC_104 0074-0074 590.992 µM 0.387408356397319 0.315566421855003 no 1075 0.349226959188233 1698 3943124
SGTC_1232 0279-0259 161 µM 0.386989034611872 0.315732157647009 no 1076 0.349382162920442 1614 1560000
SGTC_359 0081-0058 15.9 µM 0.386279412226047 0.316012718374706 no 1077 0.34964487309199 1794 3494159
SGTC_403 arphamenine a 50 µM 0.385656457096246 0.316259101177053 no 1078 0.349875557441363 1689 5487158 An arginine aminopeptidase inhibitor.
SGTC_2684 capsaicin 100 µM 0.384342454789283 0.316779065112655 no 1079 0.35036232273794 1670 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.383048295769984 0.317291530907449 no 1080 0.350841977545375 1641 3256 An antibiotic and ribosome inhibitor.
SGTC_392 N-ethylmaleimide 8.33 µM 0.381615960060655 0.317859121042752 no 1081 0.351373122102442 1637 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.381277348158488 0.317993365048601 no 1082 0.351498730022263 1759 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_13 0199-0087 65 µM 0.37998548027912 0.318505750680716 no 1083 0.351978096641436 1695 4589825
SGTC_934 2950-0684 338 µM 0.379809284507553 0.318575661064753 no 1084 0.3520434949353 1768 1121253
SGTC_1470 k295-0292 231 µM 0.379549876376957 0.318678599932101 no 1085 0.352139786987886 1733 5045612
SGTC_3174 9107204 49.47 µM 0.379447833815599 0.31871909650646 no 1086 0.35217766768875 1708 3938802
SGTC_2021 4019055 173 µM 0.379046078304424 0.318878558092941 no 1087 0.35232682343795 1668 44827708 YER133W GLC7
SGTC_314 1671-0008 2.74 µM 0.378386822615047 0.319140297245257 no 1088 0.352571627913178 1657 3913060
SGTC_2636 apigenin dimethyl ether 100 µM 0.377164507832684 0.31962582191231 no 1089 0.353025677261741 1690 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1234 0326-0494 15.5 µM 0.372983424710093 0.321288955316654 no 1090 0.35458039021714 1759 1547813
SGTC_887 0885-0007 9.62 µM 0.371680824739485 0.321807833030547 no 1091 0.355065251736898 1737 5719458
SGTC_3 0833-0587 95.581 µM 0.369563610588493 0.322651945722749 no 1092 0.355853834461941 1685 5382644
SGTC_1913 st060213 96.1 µM 0.369370691895592 0.322728906068922 no 1093 0.355925720157611 1803 688959
SGTC_1088 bifonazole 369 nM 0.369190196821207 0.322800917182721 no 1094 0.355992981181631 1655 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3157 9099274 49.47 µM 0.368460919638305 0.323091940476899 no 1095 0.356264790064998 1798 17217662
SGTC_1560 lithocholic acid 53.1 µM 0.367236458378867 0.323580814092061 no 1096 0.35672132321804 1769 9903 A bile acid which acts as a detergent.
SGTC_1310 1188-0297 994 nM 0.367169216523947 0.323607669643746 no 1097 0.356746399899765 1691 1588352
SGTC_1180 1193-0155 285 µM 0.363399234254266 0.325114819342502 no 1098 0.358153336855295 1656 2921347
SGTC_1008 4106-0037 6 µM 0.362091366035377 0.325638344962037 no 1099 0.358641877712158 1692 2905394
SGTC_2624 nerol 100 µM 0.361626689302256 0.325824432977122 no 1100 0.358815508727706 1770 637566 A natural product oil.
SGTC_1434 4073-0095 163 µM 0.361471551354891 0.325886570377798 no 1101 0.358873484040986 1728 24133745
SGTC_1990 st072050 59.8 µM 0.360278490561093 0.326364588508847 no 1102 0.35931944142878 1644 17233948
SGTC_3263 9137018 49.47 µM 0.3588882395243 0.326921973896861 no 1103 0.359839348928342 1591 43844957
SGTC_634 1611-4317 11.2 µM 0.357545871775191 0.327460528410889 no 1104 0.360341595904203 1787 2843522
SGTC_694 1315-0438 43.2 µM 0.35730344858264 0.327557826307868 no 1105 0.360432324283425 1743 6793154
SGTC_2080 5212524 12.4 µM 0.356970673168165 0.327691406644842 no 1106 0.360556880338244 1830 260183
SGTC_2741 miltefosine 3.04 µM 0.356959144785013 0.327696034681666 no 1107 0.360561195615552 1699 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1358 1509-0022 2.48 µM 0.356158679916762 0.328017443731371 no 1108 0.360860867140728 1725 3258434
SGTC_749 1000-0129 128 µM 0.354619173321302 0.328635956703893 no 1109 0.361437455148865 1826 708470
SGTC_2377 9073351 62.6 µM 0.354446569417251 0.328705331455672 no 1110 0.361502119760092 1648 7337946 YHR072W ERG7
SGTC_2079 5212404 121 µM 0.353911909354978 0.328920265032841 no 1111 0.361702450787808 1823 758462
SGTC_1630 st005209 31.3 µM 0.353910059159807 0.328921008910385 no 1112 0.361703144100689 1815 3367314
SGTC_422 cantharidin 155 µM 0.353900836647183 0.328924716864471 no 1113 0.361706600006003 1606 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2523 spermine 47.74 µM 0.35324592246674 0.329188071185833 no 1114 0.361952041495936 1829 1103 A DNA binding polyamine.
SGTC_1281 0884-0031 11.8 µM 0.353042630489913 0.329269836277114 no 1115 0.362028240567654 1662 1548255
SGTC_2840 9008771 71.43 µM 0.352938519692304 0.32931171334408 no 1116 0.3620672660953 1846 2992978
SGTC_2252 omeprazole 400 µM 0.352776232146892 0.329376995439302 no 1117 0.362128101810373 1768 4594 A proton pump inhibitor.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.352091680019692 0.329652421898314 no 1118 0.362384753891687 1674 115019
SGTC_1835 st008666 49.2 µM 0.351379419805151 0.329939094686615 no 1119 0.362651859953356 1655 690455
SGTC_1753 st043925 64 µM 0.350498604015278 0.330293746421601 no 1120 0.362982268812738 1823 670181
SGTC_3261 9137475 49.47 µM 0.350214990573119 0.33040797303265 no 1121 0.363088678722879 1715 17027690
SGTC_2462 5162487 171.77 µM 0.349556581192463 0.330673211335105 no 1122 0.363335750358239 1816 2259986
SGTC_3045 9092950 49.47 µM 0.349502294389961 0.330695084412599 no 1123 0.363356124309832 1827 44120432
SGTC_852 0418-0143 439 µM 0.348739910317149 0.331002322986095 no 1124 0.363642289472146 1806 5369229
SGTC_604 1000-0114 314 µM 0.347693768728993 0.3314241002755 no 1125 0.364035088436558 1812 1572745
SGTC_1020 4335-0961 93.3 µM 0.347423290656068 0.331533184874591 no 1126 0.364136669184868 1625 669075
SGTC_2052 5265182 7.135 µM 0.347315452084561 0.331576680471538 no 1127 0.364177171702137 1802 1239884
SGTC_278 4092-0821 23.9 µM 0.34656549383671 0.331879231336068 no 1128 0.364458886480748 1766 877900
SGTC_1296 1068-0102 11.9 µM 0.345465408086504 0.332323230283664 no 1129 0.36487225582393 1779 767053
SGTC_84 0443-0269 128.823 µM 0.344879514851227 0.33255979522803 no 1130 0.365092475818215 1750 6150058
SGTC_333 3486-0131 40.1 µM 0.344710956819953 0.332627865927462 no 1131 0.365155840059084 1841 6744690
SGTC_2420 aureobasidin a 50 nM 0.344313718985268 0.332788308808171 no 1132 0.365305184043683 1845 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_712 r015-0009 80.6 µM 0.344304064043114 0.332792208784655 no 1133 0.365308814132389 1765 6813872 YLR060W FRS1
SGTC_79 0052-0007 94.094 µM 0.343581621859223 0.333084080322733 no 1134 0.36558047391998 1802 2801472
SGTC_1803 st050068 52.4 µM 0.343349577567161 0.333177849256911 no 1135 0.365667743803217 1731 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2341 7987486 176.74 µM 0.342151759364267 0.333662052503358 no 1136 0.366118343529399 1859 1258686
SGTC_907 3448-6986 75.5 µM 0.340903041007337 0.334167126624184 no 1137 0.366588287707057 1813 590582
SGTC_1490 4089-0339 670 nM 0.340609262787496 0.334285995968542 no 1138 0.366698877656782 1823 742542
SGTC_563 tetrahydrosecaminediol 614 µM 0.340017896883785 0.334525326443894 no 1139 0.366921525142649 1829 334274 A psychoactive constituent of the cannabis plant.
SGTC_2606 farnesol 9.78 µM 0.339212504920788 0.33485138313028 no 1140 0.367224824795468 1813 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2193 5925765 200 µM 0.339034033489189 0.334923652769196 no 1141 0.367292045930743 1781 877370
SGTC_42 0133-0086 60.653 µM 0.337932279111349 0.335369928861279 no 1142 0.367707110906353 1627 162923 Model of phenazepam hydroxylation.
SGTC_1147 3809-1045 12.3 µM 0.336592762476679 0.335912825847059 no 1143 0.368211956437741 1700 325925
SGTC_1895 st058434 18.3 µM 0.335741815490189 0.336257886882595 no 1144 0.368532785045406 1852 5393175
SGTC_1854 st056233 32.9 µM 0.334985587167902 0.336564655096525 no 1145 0.368817979254539 1850 5393174
SGTC_570 0987-0065 62.6 µM 0.334793278058063 0.336642683714515 no 1146 0.368890515764728 1837 3104428
SGTC_1638 st008370 60.6 µM 0.333690733731866 0.33709017214066 no 1147 0.369306471302516 1693 24207134
SGTC_1932 st074806 40.9 µM 0.333380249127449 0.337216229822523 no 1148 0.369423635086399 1786 17251235
SGTC_2438 5259590 200 µM 0.333188268456653 0.337294183697298 no 1149 0.369496086556577 1849 1201127
SGTC_1718 roemerine 11.9335 µM 0.33298342784118 0.33737736706368 no 1150 0.369573396344132 1727 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3147 9097027 49.47 µM 0.332552928632419 0.337552213635847 no 1151 0.369735890106502 1793 25236841
SGTC_3287 9117173 37.0625 µM 0.33189085827424 0.337821180905251 no 1152 0.369985836779932 1766 2789709
SGTC_1883 5-benzylidenerhodanine 20 µM 0.331520713259312 0.337971589092289 no 1153 0.370125598917273 1840 1273210
SGTC_1500 4488-1866 171 µM 0.331099469342904 0.338142792759777 no 1154 0.370284676227472 1824 2900003
SGTC_2358 9037157 4 µM 0.33052190793754 0.338377582028305 no 1155 0.370502820875307 1760 2388925
SGTC_2077 5212015 200 µM 0.329688797427143 0.338716367380001 no 1156 0.370817559637384 1679 780900
SGTC_956 1185-0240 191 µM 0.327860633742817 0.33946024943885 no 1157 0.371508519838914 1751 1416193
SGTC_3068 9116768 49.47 µM 0.327383317903838 0.339654573010972 no 1158 0.371688991143324 1725 41904888
SGTC_1423 4048-0112 5.59 µM 0.325646153616219 0.340362162352355 no 1159 0.37234604419339 1845 X1423
SGTC_932 2857-0803 154 µM 0.325243837017757 0.340526116003595 no 1160 0.372498266740426 1857 674898
SGTC_2902 5787006 60.46 µM 0.324429899735874 0.340857907091165 no 1161 0.372806293068576 1710 591003
SGTC_1022 4477-0945 21.3 µM 0.324268166744456 0.340923850142659 no 1162 0.372867508976704 1704 4648966
SGTC_2977 9011197 71.43 µM 0.324050012758631 0.34101280530645 no 1163 0.372950085306704 1805 2704722
SGTC_1012 4112-3522 18 µM 0.32384269435069 0.341097350311707 no 1164 0.373028565529901 1854 3112398
SGTC_466 geldanamycin 89.2 µM 0.323634017105023 0.341182457512049 no 1165 0.373107565461207 1843 5288382 HSP90 inhibitor.
SGTC_3039 9090270 49.47 µM 0.322730216098439 0.341551158126286 no 1166 0.373449783237354 1884 17173750
SGTC_1138 3761-0006 1.03 µM 0.322580210048786 0.341612366907151 no 1167 0.373506591620021 1780 12061087
SGTC_1316 1272-0050 65.9 µM 0.322142597146801 0.341790955181672 no 1168 0.373672334514056 1758 7340392
SGTC_1140 3229-1848 2.98 µM 0.321152720671231 0.342195050859414 no 1169 0.374047329623778 1851 2849525
SGTC_1512 0259-0544 12.2 µM 0.320599926564482 0.342420795803545 no 1170 0.374256796634347 1799 18476
SGTC_2448 5185112 27.17 µM 0.319213444165416 0.342987242236303 no 1171 0.374782331440088 1739 5718189
SGTC_864 0469-0573 172 µM 0.318275729726644 0.343370545062229 no 1172 0.375137896358595 1706 689425
SGTC_3294 9122953 26.2835 µM 0.31670328850896 0.344013662168374 no 1173 0.375734376641525 1699 16459826
SGTC_2075 5212009 200 µM 0.316577613997331 0.344065081645086 no 1174 0.375782062085908 1842 780898
SGTC_1738 st035555 74 µM 0.316506601640727 0.344094137484743 no 1175 0.375809007575255 1761 5331140
SGTC_2046 4110841 106 µM 0.316104933034042 0.344258503933442 no 1176 0.375961431280698 1872 44119630 YMR134W ERG29
SGTC_3040 9091894 49.47 µM 0.316074122272833 0.344271113192675 no 1177 0.375973124033028 1834 25236966
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.314994854407625 0.344712911147316 no 1178 0.376382780369335 1809 616764
SGTC_3308 9128332 17.569 µM 0.314354017247505 0.344975337921864 no 1179 0.376626088054228 1880 17332805 YDL196W YDL196W
SGTC_163 TUB2.036 7.546 µM 0.313340127808172 0.345390684222259 no 1180 0.377011133196371 1810 15992207 YJR013W GPI14
SGTC_759 3486-0358 89.3 µM 0.312105271853418 0.345896802404219 no 1181 0.377480260079891 1917 875103
SGTC_3309 9129340 25.759 µM 0.311988637589758 0.345944620386761 no 1182 0.377524579275935 1797 17158987
SGTC_1445 4239-0156 97.7 µM 0.310565662516631 0.346528212613622 no 1183 0.378065417249329 1881 4008346
SGTC_529 4076-0302 30.3 µM 0.308753508070582 0.34727194304175 no 1184 0.378754518719482 1735 5816522
SGTC_1211 1056-0033 32.3 µM 0.308645160047999 0.347316429073116 no 1185 0.378795732072428 1902 6741922
SGTC_2640 pentamidine 10.38 µM 0.308246783554569 0.34748001441487 no 1186 0.378947278120068 1912 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2845 9003024 42.97 µM 0.308114240944675 0.347534446687463 no 1187 0.378997702663526 1848 2990173
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.307828501337786 0.347651804218702 no 1188 0.379106416514694 1839 688761
SGTC_1085 doxorubicin 7.67 µM 0.307750330476298 0.347683912705068 no 1189 0.379136159439057 1858 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_56 0957-0365 83.25 µM 0.306839756471562 0.348058009142504 no 1190 0.379482672838506 1855 6752360
SGTC_1969 st069479 40.1 µM 0.303970493683394 0.349237771070767 no 1191 0.38057518539261 1859 3895485
SGTC_1553 gossypol 38.6 µM 0.303452135580239 0.349451061518446 no 1192 0.380772659504666 1790 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2971 9092186 9.93 µM 0.303217426743177 0.349547653547366 no 1193 0.380862084588687 1641 25236400
SGTC_471 1-acyl-paf 4 µM 0.302029050717329 0.350036867007156 no 1194 0.381314958602204 1714 16759367
SGTC_2946 9065502 71.43 µM 0.299274450902227 0.351171797205364 no 1195 0.382365323489971 1781 16489101
SGTC_758 0868-0029 16 µM 0.298985702605754 0.351290842288949 no 1196 0.382475477273813 1903 762687
SGTC_1422 4031-0024 15.5 µM 0.298890246805641 0.351330199994776 no 1197 0.382511894533315 1883 782427
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.298543978984616 0.351472984237022 no 1198 0.382644007587922 1884 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1338 1486-1223 76 µM 0.297870043910853 0.351750942821351 no 1199 0.38290117608874 1858 3444526
SGTC_89 0302-0250 142.109 µM 0.297107387971486 0.352065589145233 no 1200 0.383192262065077 1819 4203518 YLR208W SEC13
SGTC_1613 st002381 52.1 µM 0.295595350880512 0.352689704433192 no 1201 0.383769562260354 1888 551167
SGTC_3195 9113082 49.47 µM 0.291976966407577 0.354184853078124 no 1202 0.38515211757316 1945 17018038
SGTC_190 3970-0790 3.722 µM 0.291709940533778 0.35429527999577 no 1203 0.3852542040966 1881 2832352
SGTC_745 0469-0705 296 µM 0.29045955473195 0.3548125322725 no 1204 0.385732344139403 1911 3486736
SGTC_1556 plumbagin 1.48 µM 0.288648301361944 0.355562275635532 no 1205 0.386425264419869 1855 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_210 3551-0445 56.827 µM 0.288604194749333 0.355580539945895 no 1206 0.38644214254864 1843 2865180 YOR207C RET1
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.288172425084791 0.355759350941197 no 1207 0.386607377732066 1877 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_773 4358-1457 44.6 µM 0.288121229746037 0.355780554836246 no 1208 0.386626971188548 1954 1186886
SGTC_649 1123-0311 367 µM 0.286791725130287 0.356331360198157 no 1209 0.387135899654614 1896 693629 YIL048W NEO1
SGTC_2937 9044753 11.33 µM 0.285955912563976 0.356677785653335 no 1210 0.387455944408844 1773 6465530 YGL099W LSG1
SGTC_2417 cerulenin 830 nM 0.283221673613457 0.357811890895957 no 1211 0.388503457556328 1792 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2644 guaiazulene 100 µM 0.282731015143984 0.358015539024285 no 1212 0.388691519605295 1908 3515 A coloring agent.
SGTC_2073 5212005 126 µM 0.281751820708108 0.358422075077859 no 1213 0.389066908128105 1952 691789
SGTC_1923 st058458 19.1 µM 0.281618577392287 0.35847740665316 no 1214 0.389117996917602 1926 3534982
SGTC_1546 5-methoxyflavanone 78.7 µM 0.280973813184632 0.358745198021644 no 1215 0.389365242562587 1963 147795
SGTC_2508 celastrol 40.54 µM 0.28036168782642 0.358999497696168 no 1216 0.38960001374655 1860 122724 Celastrol is a natural product and antioxidant.
SGTC_1666 st014829 29 µM 0.280168281276989 0.359079858979074 no 1217 0.389674200208626 1793 3858230
SGTC_393 acivicin 6.25 µM 0.28007699565796 0.359117790726955 no 1218 0.389709216743748 1828 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_312 4092-0653 6.84 µM 0.280034912862826 0.359135277782318 no 1219 0.38972535971581 1897 1148278
SGTC_851 0394-0702 453 µM 0.27971087581561 0.359269937794235 no 1220 0.389849666788465 1924 762646
SGTC_304 1310-0298 97 µM 0.278748667933294 0.359669905314545 no 1221 0.3902188552759 1829 1550234
SGTC_2608 thymoquinone 42.66 µM 0.277978750657477 0.359990052845613 no 1222 0.390514335331774 1874 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_568 1193-0097 7.48 µM 0.277955773038179 0.359999608925831 no 1223 0.390523154691162 1883 3646150
SGTC_715 0868-0130 184 µM 0.277947257494758 0.360003150447065 no 1224 0.390526423174531 1969 2876258
SGTC_3326 9140064 16.379 µM 0.277682755487413 0.360113159916955 no 1225 0.390627949661081 1753 1868434
SGTC_53 0973-0023 39.979 µM 0.275484884647761 0.361027727369079 no 1226 0.391471868516176 1990 674768
SGTC_192 3455-0609 60.9 µM 0.268714133590945 0.363850117000125 no 1227 0.394074837333428 1853 3769639
SGTC_2687 chenodiol 100 µM 0.2683369957116 0.364007546100478 no 1228 0.394219965799074 1846 5702181 A cholesterol synthesis inhibitor.
SGTC_3105 9121040 49.47 µM 0.263961066335588 0.365835867427633 no 1229 0.395904959790945 1962 41448907
SGTC_1323 1348-1351 11.2 µM 0.263888690583208 0.36586613274119 no 1230 0.395932845229229 1809 6989654
SGTC_517 1365-0151 113 µM 0.263048642783959 0.366217475923808 no 1231 0.396256543676581 1857 768657
SGTC_2793 7325131 81.82 µM 0.262064630664456 0.366629173675485 no 1232 0.39663580734151 1870 4176441
SGTC_3201 9113999 49.47 µM 0.260024629872634 0.367483171721633 no 1233 0.397422387496396 1890 16649224
SGTC_1196 1588-0294 184 µM 0.259264292560443 0.367801636929342 no 1234 0.397715664036817 1808 6144269
SGTC_2923 7992654 58.14 µM 0.256435064108466 0.368987448433246 no 1235 0.3988074577693 1830 2985126
SGTC_3188 9110789 49.47 µM 0.255852011600166 0.36923197808724 no 1236 0.399032555337703 1965 849217
SGTC_3253 9135987 49.47 µM 0.251802656274246 0.370931715048308 no 1237 0.400596802027181 1902 4182430
SGTC_448 monastrol 171 µM 0.25068645555657 0.37140069056082 no 1238 0.401028266635067 1930 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.249858112085925 0.371748845372826 no 1239 0.401348538822495 1977 1241132 A phosphatase inhibitor.
SGTC_987 1497-1013 404 µM 0.249573101634118 0.371868660245726 no 1240 0.401458751107984 1909 1676435
SGTC_540 1187-0821 17.3 µM 0.249350623163695 0.371962196071572 no 1241 0.401544788000692 1796 847520
SGTC_181 1447-1644 8.07 µM 0.249275897284822 0.371993614500615 no 1242 0.401573687069842 1973 534600
SGTC_1989 st071868 50.2 µM 0.247015356239022 0.372944458968042 no 1243 0.402448169851893 1990 16414057
SGTC_3139 9095020 49.47 µM 0.24632475494364 0.373235099203627 no 1244 0.402715424261755 1938 25236292
SGTC_1870 st057514 26.5 µM 0.245033920103495 0.373778541650845 no 1245 0.403215083670627 1846 5393161
SGTC_1113 artemisinin 1.17947 µM 0.244209458850351 0.374125771908478 no 1246 0.403534300855426 1997 2240 An anti-malaria and mitochondrial poison.
SGTC_3349 9149703 23.001 µM 0.242009459859726 0.375052823166629 no 1247 0.40438641658716 1917 4910494
SGTC_3344 9148862 3.898 µM 0.241832976187749 0.375127222480182 no 1248 0.404454792929307 1961 4905352
SGTC_1143 3454-2408 5.08 µM 0.241702635420407 0.375182172549818 no 1249 0.404505293666713 1900 X1143
SGTC_1529 apigenin 74 µM 0.24073721774545 0.375589259607188 no 1250 0.404879395759383 1990 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1489 4065-0444 182 µM 0.23984163156347 0.37596702475662 no 1251 0.40522651570587 1998 2877968
SGTC_2257 7960413 200 µM 0.236929041613913 0.377196397987241 no 1252 0.406355919696264 1935 2974689 YIL048W NEO1
SGTC_1594 piperine 70.1 µM 0.236907914157084 0.377205320227694 no 1253 0.406364115069457 1837 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.235560614696451 0.377774427340791 no 1254 0.406886819180116 2022 1273210
SGTC_2427 5545055 42.75 µM 0.234959457290974 0.378028445426169 no 1255 0.407120100385635 1899 5372858
SGTC_1772 st048439 82.2 µM 0.234919821815878 0.378045195186246 no 1256 0.407135482227324 1859 2927068 YDL195W SEC31
SGTC_1550 gossypolone 36.6 µM 0.233688309348888 0.378565740468289 no 1257 0.407613482140297 1985 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2678 equilin 100 µM 0.233119250439599 0.378806349234775 no 1258 0.407834403489415 2007 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_260 nsc-65238 3.989 µM 0.232716621596162 0.37897661663532 no 1259 0.407990730687055 1956 3246252
SGTC_2650 prasterone 100 µM 0.231487450030202 0.379496565218189 no 1260 0.408468067060393 1936 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1644 st010134 20.9 µM 0.231363398378925 0.37954905210251 no 1261 0.408516248825112 2005 3818134
SGTC_2449 5812982 45.77 µM 0.230832612835641 0.379773655220797 no 1262 0.408722421980935 1935 776185
SGTC_2299 7976368 114.88 µM 0.230468041239241 0.379927948031835 no 1263 0.408864047251619 1985 2979718
SGTC_2983 9022671 12.99 µM 0.230310449924 0.379994649236795 no 1264 0.408925270496343 2049 6405161
SGTC_3013 9080133 71.4286 µM 0.230021308210341 0.380117038998389 no 1265 0.409037606029462 1935 17050193
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.229018623993366 0.380541554546096 no 1266 0.409427220463554 1858 6708561
SGTC_49 0717-0965 32.132 µM 0.226597328025722 0.38156727304295 no 1267 0.41036843509086 1983 5889349 YGL099W LSG1
SGTC_1429 4049-0205 9.46 µM 0.226291574805096 0.381696856702144 no 1268 0.410487325391709 1977 22774478
SGTC_917 harmaline 728.087 nM 0.226209265478726 0.381731743125988 no 1269 0.410519332283981 1936 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1488 4013-0813 75.9 µM 0.225610053866375 0.381985745107048 no 1270 0.410752360297773 1888 2910057
SGTC_925 2064-1272 59.6 µM 0.225283028788252 0.382124390390186 no 1271 0.410879550707207 1838 6815817
SGTC_3004 9076122 71.4286 µM 0.22496733074906 0.382258247812004 no 1272 0.411002344562254 1986 44782551
SGTC_2283 7944793 200 µM 0.223850083980919 0.382732078510854 no 1273 0.411436978640894 1845 2970533
SGTC_981 1488-1094 54.9 µM 0.223455268398674 0.382899564064067 no 1274 0.411590596790668 1898 3449522
SGTC_2089 5281248 129.67 µM 0.222701036846876 0.383219579074248 no 1275 0.411884097170062 1864 2737878
SGTC_2221 6807166 181.081 µM 0.222571448372081 0.383274570559723 no 1276 0.411934529975697 1975 674925
SGTC_2722 naftopidil 47.16 µM 0.221887628902573 0.383564791530191 no 1277 0.412200680602228 1991 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_123 0083-0120 66.675 µM 0.221804954972511 0.383599883742127 no 1278 0.412232861012643 1825 16001701
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.221427095356744 0.383760284175618 no 1279 0.412379948471727 2020 688662
SGTC_91 0417-1751 58.384 µM 0.218289388418967 0.385092999708749 no 1280 0.41360182096383 2043 6795624
SGTC_2338 7999974 200 µM 0.217890722980984 0.38526242720559 no 1281 0.413757127744064 2052 315925
SGTC_701 4424-0219 185 µM 0.217182745173344 0.385563362303836 no 1282 0.414032965562771 2055 2911779
SGTC_1055 3448-0672 86 µM 0.215306553180665 0.386361194716193 no 1283 0.414764160370199 1951 748378
SGTC_395 anisomycin 6.25 µM 0.214799890195687 0.386576730800321 no 1284 0.414961669255298 1902 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1976 st070609 63.5 µM 0.214764735458876 0.386591687038918 no 1285 0.414975374178347 1992 682556
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.214402796344919 0.386745680283058 no 1286 0.415116480600042 1908 2333 A French combination drug.
SGTC_1663 st014140 55.4 µM 0.213968682680068 0.386930404956274 no 1287 0.415285739601402 2024 4207120
SGTC_2107 5363541 170.161 µM 0.21367618328661 0.387054884167077 no 1288 0.415399792691202 2019 244052
SGTC_766 1391-0721 126 µM 0.213594710520497 0.38708955866918 no 1289 0.415431562302735 2010 1020919 YIL115C NUP159
SGTC_1405 3909-7894 12 µM 0.210768259005739 0.388293041810795 no 1290 0.416534053893463 2023 7104060
SGTC_1513 0337-0559 19 µM 0.210422114237674 0.388440501819505 no 1291 0.416669117170588 1868 775073
SGTC_2738 aclarubicin 5.55 µM 0.208952709639176 0.389066656881514 no 1292 0.417242577945415 1996 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3035 9091303 49.47 µM 0.207905158014954 0.389513224485434 no 1293 0.417651510830192 1972 25237002
SGTC_196 k015-0023 18.111 µM 0.206288624662608 0.390202633184449 no 1294 0.41828273182504 1917 5211998
SGTC_3127 9126946 49.47 µM 0.205646260194704 0.390476680663832 no 1295 0.41853361966996 1864 27243249
SGTC_415 dibenzyl ketone 100 µM 0.205525303817086 0.390528289533485 no 1296 0.418580865229634 2041 7593
SGTC_629 3448-6466 76.7 µM 0.204325954653651 0.391040124167876 no 1297 0.419049394453598 1966 573744
SGTC_2529 gangaleoidin 93.61 µM 0.204045968348883 0.391159638425644 no 1298 0.419158788470749 1952 4565183
SGTC_3220 9131269 49.47 µM 0.202601598319798 0.391776341665103 no 1299 0.419723220316509 2016 17722206
SGTC_1548 st061468 90.8 µM 0.199378901533798 0.393153316315823 no 1300 0.420983181648345 2057 390799
SGTC_3008 9078912 71.4286 µM 0.199031289991136 0.393301921939158 no 1301 0.421119134170971 1918 16648731
SGTC_1843 st055809 45.5 µM 0.198400362892299 0.393571686042759 no 1302 0.421365916770238 1951 16413835
SGTC_861 0443-0273 110 µM 0.198189095560689 0.393662028573376 no 1303 0.421448559377271 1993 6149169
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.198135924705702 0.393684766495432 no 1304 0.421469359058979 1956 1377
SGTC_55 0767-0285 6.563 µM 0.196169122873715 0.394526101415725 no 1305 0.422238897432421 2065 3116166
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.194591814290653 0.395201179463598 no 1306 0.42285625590525 1953 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_584 0986-0246 15.4 µM 0.19443974138829 0.395266282362337 no 1307 0.422915787269184 2073 53315 YDR232W HEM1
SGTC_3228 9131799 49.47 µM 0.194380763858503 0.395291531619408 no 1308 0.422938875437999 1984 17015818
SGTC_1417 3966-0327 90.4 µM 0.193825926689999 0.395529088105427 no 1309 0.423156092704497 1969 651118
SGTC_1953 st076800 12.1 µM 0.19193173631798 0.396340387788771 no 1310 0.423897838790864 1859 297591
SGTC_892 0929-0076 29 µM 0.191426773523047 0.396556744101171 no 1311 0.424095622833429 1918 5751038
SGTC_2726 cimetidine 79.27 µM 0.190678386023612 0.396877456711783 no 1312 0.424388786719684 2079 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2016 5121758 140 µM 0.190547431265039 0.396933583002138 no 1313 0.424440089591672 2047 2795203
SGTC_1402 3909-7673 35.9 µM 0.19024881086745 0.397061577591805 no 1314 0.424557081986882 2015 5328014
SGTC_319 1348-1596 45.5 µM 0.186101529691165 0.398840324599976 no 1315 0.426182571175218 2084 5380505
SGTC_513 4245-1575 41.7 µM 0.18577142314531 0.398981996398081 no 1316 0.426312007718058 2042 719745
SGTC_2744 captopril 92.04 µM 0.184167050850238 0.399670733918085 no 1317 0.426941203469944 2092 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_252 miconazole 1.30953 nM 0.184018195767629 0.399734651459625 no 1318 0.426999590259129 2054 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3079 9117512 49.47 µM 0.181337570456004 0.400886155289073 no 1319 0.428051308940523 2034 7185044
SGTC_2028 5153890 36.43 µM 0.181024387136657 0.401020744408389 no 1320 0.428174217037029 1978 2830968 YPR165W RHO1
SGTC_2378 9074213 121.43 µM 0.180470913200128 0.401258626053578 no 1321 0.428391443683116 2074 657714
SGTC_328 k915-0120 63.5 µM 0.180182457550521 0.401382618050688 no 1322 0.428504664942661 2083 6624543
SGTC_1939 st074455 53.6 µM 0.179163522978223 0.401820684149883 no 1323 0.428904652346666 2107 1644229
SGTC_2932 9016711 44.54 µM 0.178061762731413 0.402294497957422 no 1324 0.429337235506042 2113 7117328
SGTC_1370 2001-0092 44.6 µM 0.177296619021279 0.402623633800558 no 1325 0.429637703178286 2079 790957
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.176869225782928 0.402807512247686 no 1326 0.429805555876938 1960 4330530
SGTC_2327 6189656 200 µM 0.176514729872488 0.402960044211483 no 1327 0.429944788801086 2069 5349088
SGTC_3250 9135583 49.47 µM 0.175311612027758 0.403477829925132 no 1328 0.430417393995915 2106 7699353
SGTC_2330 7979373 200 µM 0.175021008739384 0.403602922245208 no 1329 0.430531562893772 1894 1863007
SGTC_1288 0973-0013 65.5 µM 0.174565296502593 0.403799106778731 no 1330 0.430710609597403 2018 4315430
SGTC_225 nsc-122657 1.016 µM 0.174517063451243 0.403819872568636 no 1331 0.430729560918684 2070 275685
SGTC_2216 7189485 200 µM 0.173270249382241 0.404356757714705 no 1332 0.43121950376005 2095 731273
SGTC_3302 9125395 16.351 µM 0.172666142731794 0.404616954292008 no 1333 0.431456929098483 1995 17599668
SGTC_1487 3970-0795 2.82 µM 0.170426910829135 0.405581787677827 no 1334 0.432337204965895 2041 3765103
SGTC_1701 st028638 40.4 µM 0.167353573898656 0.406906951082741 no 1335 0.433545926293515 2083 3490878
SGTC_3314 9135860 59.4275 µM 0.166500208851353 0.407275095409087 no 1336 0.433881659412861 2123 25252478
SGTC_2367 9070478 135.38 µM 0.163515015702166 0.408563559495776 no 1337 0.435056475719842 2012 572802
SGTC_1973 st070275 50.2 µM 0.163428919233325 0.408600735049506 no 1338 0.435090367358025 2136 17118334
SGTC_369 0957-0393 4.5 µM 0.161997019225579 0.40921913481587 no 1339 0.435654100589937 1958 6997992
SGTC_3219 9131112 49.47 µM 0.161281702827243 0.409528145805639 no 1340 0.435935766813203 2130 17612988 YMR079W SEC14
SGTC_1891 st059073 26.2 µM 0.16117000913924 0.409576401668659 no 1341 0.435979750762294 2154 688754
SGTC_2967 9089538 49.85 µM 0.158988984850523 0.410518959650863 no 1342 0.436838776130358 2153 728216
SGTC_1151 3909-8316 15.3 µM 0.158821950797912 0.410591166970788 no 1343 0.436904577041889 2031 800431
SGTC_492 tmb-8 126 µM 0.157340136508069 0.411231874395624 no 1344 0.437488394905565 2127 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_896 0964-0007 44.5 µM 0.155440034470675 0.412053787587989 no 1345 0.438237212377566 2157 6756758
SGTC_2147 5545932 89.7195 µM 0.152372142876557 0.413381656099126 no 1346 0.439446713634583 2030 797404
SGTC_1192 1488-0095 21.4 µM 0.152218027459331 0.413448387800328 no 1347 0.43950748789516 2036 915875
SGTC_2312 7706453 155.7 µM 0.151387271360338 0.413808146727452 no 1348 0.439835114862106 2017 976098
SGTC_1306 1185-0270 9.02 µM 0.151366633354437 0.413817084938156 no 1349 0.439843254439801 2115 1548076
SGTC_1161 k007-0610 110 µM 0.151316806084185 0.413838665048192 no 1350 0.439862906294847 2148 5843850
SGTC_3260 9137109 49.47 µM 0.150825665939125 0.41405139096227 no 1351 0.440056619688169 2144 17478346
SGTC_1678 st019265 80.2 µM 0.150187588998577 0.414327796784789 no 1352 0.440308308688656 2157 5367020
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.147901350849421 0.415318509997649 no 1353 0.44121031105455 2099 688751
SGTC_2437 5741531 144.16 µM 0.147844624898966 0.415343098365308 no 1354 0.441232695359522 2144 2262990
SGTC_874 0599-0792 117 µM 0.14698160218044 0.415717224073972 no 1355 0.441573270963552 2168 765305
SGTC_3160 9100216 49.47 µM 0.146711019029084 0.415834539300173 no 1356 0.441680060398094 2168 17191039
SGTC_2653 dihydrofissinolide 100 µM 0.145194249367425 0.416492295239605 no 1357 0.44227875308148 2080 6857746
SGTC_747 3448-8087 38.7 µM 0.144921822673813 0.416610459482858 no 1358 0.442386298161696 2035 5168703
SGTC_2120 5538279 151.968 µM 0.144704409277378 0.416704767284285 no 1359 0.442472128852096 2063 2058197
SGTC_643 k048-0106 28.4 µM 0.144439200195669 0.41681981399684 no 1360 0.442576832029284 2094 6763920
SGTC_1654 st012436 41.8 µM 0.143619486194085 0.417175447877109 no 1361 0.442900476213152 2131 4323132
SGTC_271 rotenone 740 µM 0.140477370326738 0.418539283889651 no 1362 0.444141415524289 2095 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.140348021435828 0.418595448910966 no 1363 0.44419251207212 2074 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2820 7989630 71.43 µM 0.140226304858457 0.418648301395066 no 1364 0.444240594482798 2175 2984098
SGTC_775 4577-0580 57.3 µM 0.139163563161033 0.419109833598032 no 1365 0.444660450332856 2103 2006902
SGTC_1929 genistein trimethyl ether 50.5 µM 0.13879388818985 0.419270403824838 no 1366 0.444806511878943 2197 136420
SGTC_849 0386-0493 241 µM 0.138625288411796 0.419343640472544 no 1367 0.44487312949313 2058 726119
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.138026258070489 0.419603870837856 no 1368 0.445109832611895 2170 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3181 9108277 49.47 µM 0.137693227572724 0.41974856094293 no 1369 0.445241436015074 2076 17097298
SGTC_2670 beta-carotene 100 µM 0.137151051182085 0.419984140825485 no 1370 0.445455700341933 2153 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2035 5154463 94.595 µM 0.136134847942812 0.420425766254205 no 1371 0.445857339642483 2144 2769623
SGTC_3144 9087057 49.47 µM 0.135864272450637 0.42054337088224 no 1372 0.445964289988068 2216 17249618
SGTC_1778 st046819 58.9 µM 0.13420774543164 0.421263528426472 no 1373 0.446619150677542 2081 671715
SGTC_484 loperamide 105 µM 0.133762683102296 0.421457059557842 no 1374 0.44679511825836 2176 3955 An opioid-receptor agonist.
SGTC_2999 9069765 71.4286 µM 0.132420479728274 0.422040818678123 no 1375 0.447325858418068 2115 2097066
SGTC_2220 6782180 200 µM 0.131755278738541 0.422330195446875 no 1376 0.447588930239438 2166 833803
SGTC_2698 st077697 67.5 µM 0.130972215527543 0.422670898543634 no 1377 0.447898643420443 2035 3154499
SGTC_19 0279-0214 38.434 µM 0.129390574815557 0.423359231043613 no 1378 0.448524302598628 2175 3566274 YBR002C RER2
SGTC_871 0574-0004 149 µM 0.127953325436873 0.423984927187081 no 1379 0.449092955116816 2043 9551173
SGTC_541 4513-1321 94 µM 0.124638225110781 0.425428860575232 no 1380 0.450404982540134 2002 747515
SGTC_86 0417-1630 471.922 µM 0.124522598898647 0.425479241190429 no 1381 0.45045075414903 2179 3634867
SGTC_942 3253-1115 227 µM 0.124188165346763 0.425624967314352 no 1382 0.450583146191888 2162 46497897
SGTC_3354 9151612 71.43 µM 0.122446226473371 0.426384163844962 no 1383 0.451272815241151 2180 27261949
SGTC_1162 k048-0130 20.1 µM 0.121989932606576 0.426583077530847 no 1384 0.451453495668398 2058 6797406
SGTC_499 genistein 192 µM 0.121185970314351 0.42693359686569 no 1385 0.451771868140464 2209 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1850 st056238 17 µM 0.120845549361127 0.427082034324305 no 1386 0.45190668563945 2186 5393177
SGTC_377 3970-0964 33.1 µM 0.119224844160858 0.427788869321585 no 1387 0.452548612117532 2127 16481235
SGTC_1820 st053765 18.6 µM 0.118996133544783 0.427888635152684 no 1388 0.452639209500724 2071 3690829
SGTC_1739 st037196 92.5 µM 0.118812524924513 0.42796873038395 no 1389 0.452711942760551 2190 612214
SGTC_1133 3473-0247 50 µM 0.118590773461925 0.428065468549765 no 1390 0.452799787737977 1953 711311
SGTC_2985 9022375 71.43 µM 0.118050440496621 0.428301204680551 no 1391 0.453013845763107 2106 4939335
SGTC_2054 5233173 129 µM 0.117264465355023 0.428644155086802 no 1392 0.453325241624429 2118 6889
SGTC_2710 st078562 53.7235 µM 0.11657725494189 0.428944054906621 no 1393 0.453597531366395 2186 17250908
SGTC_318 1488-0629 67.2 µM 0.115072027377582 0.429601081947015 no 1394 0.454194015755981 2084 3662576
SGTC_3185 9108267 49.47 µM 0.114837508369954 0.429703466354599 no 1395 0.454286959165281 2074 4910486
SGTC_1357 1503-1303 39.5 µM 0.1147599737181 0.429737316844788 no 1396 0.454317687864571 2167 292895
SGTC_1314 1222-0010 41.1 µM 0.114462863423188 0.429867035615731 no 1397 0.454435441782749 2108 3526027
SGTC_2087 5276107 200 µM 0.113963261490444 0.430085179582228 no 1398 0.454633458368091 2186 144405
SGTC_2517 totarol 10 µM 0.112858422613054 0.430567667211944 no 1399 0.455071399806005 2069 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1804 st050076 49.1 µM 0.112074032148041 0.430910276687649 no 1400 0.455382353514497 2152 3895976
SGTC_2279 7948423 32.93 µM 0.111199099091298 0.431292495091621 no 1401 0.455729233012196 2225 1247112
SGTC_1628 st004252 77.7 µM 0.110643963970022 0.431535041732488 no 1402 0.45594934164433 2184 692968
SGTC_165 k038-0023 64.381 µM 0.110505427457946 0.431595574386258 no 1403 0.456004272872192 2164 46368543
SGTC_2127 5253358 187.912 µM 0.110411851789173 0.431636462592636 no 1404 0.456041377114522 2129 20612
SGTC_2661 dactinomycin 12.96 µM 0.110027062153174 0.431804605425362 no 1405 0.456193956356605 2202 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_177 1327-0068 8.361 µM 0.109738923491456 0.431930522445736 no 1406 0.456308215168603 2218 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2821 7996764 71.43 µM 0.109420520491298 0.432069673069517 no 1407 0.456434479235311 2147 2987135
SGTC_2706 st078239 82.5 µM 0.109354175519705 0.432098668657435 no 1408 0.456460789170784 2236 15434492
SGTC_2496 diffractaic acid 79.83 µM 0.109190637289559 0.432170143414665 no 1409 0.456525643134022 2213 94870 An apoptosis inducer which activates caspases.
SGTC_829 1635-0120 117 µM 0.108815481343161 0.432334114562555 no 1410 0.456674422199591 2207 285054
SGTC_113 0099-0221 2.5 µM 0.107898545270017 0.432734933061766 no 1411 0.457038085546226 2207 89219
SGTC_2703 st077852 53.4 µM 0.107672719753012 0.432833658374042 no 1412 0.457127655080764 2132 6281836
SGTC_2183 6420625 130.508 µM 0.107603441626602 0.432863945892477 no 1413 0.457155133411162 2195 2897619
SGTC_62 0180-0423 3.232 µM 0.107206975929011 0.433037283250133 no 1414 0.457312390668358 2173 30102 YGL099W LSG1
SGTC_3158 9100007 49.47 µM 0.106003814423066 0.433563391956458 no 1415 0.457789662884404 2120 19297233
SGTC_2382 9035899 200 µM 0.105997534716503 0.433566138205289 no 1416 0.457792154089702 2176 6462679
SGTC_276 colchicine 750 µM 0.105932765708452 0.433594463252953 no 1417 0.457817848523334 2121 2833 A microtubule depolymerizer.
SGTC_1084 voriconazole 435 nM 0.105845096310016 0.433632803736285 no 1418 0.457852628023499 2216 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2194 5927483 104.545 µM 0.105416366239022 0.433820309370037 no 1419 0.458022715019831 2213 760979
SGTC_71 0417-1750 47.813 µM 0.105157542553876 0.43393351344541 no 1420 0.45812540000139 2229 6811472
SGTC_1076 itraconazole 331 nM 0.105138724710471 0.433941744188605 no 1421 0.458132865848773 2221 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1249 0481-0015 10.2 µM 0.104690883555288 0.434137634034093 no 1422 0.458310548038889 2165 4227577
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.104634657984264 0.434162228760445 no 1423 0.458332856275671 2193 6728940
SGTC_554 4483-2211 187 µM 0.104012123720404 0.43443456065626 no 1424 0.458579863710094 2127 747107
SGTC_1212 0520-0165 585 µM 0.102908514089302 0.434917418676248 no 1425 0.45901779015711 2242 5403258
SGTC_2848 9016370 25.97 µM 0.101766564084106 0.435417153802493 no 1426 0.459470982909998 2224 7894410
SGTC_3255 9139072 49.47 µM 0.101730677170478 0.435432860151425 no 1427 0.459485225799246 2134 17646060
SGTC_1392 3455-1037 33.9 µM 0.101641378556548 0.435471943229636 no 1428 0.459520667085133 2188 981132
SGTC_1097 itavastatin 7.23 µM 0.101527907312991 0.435521606785306 no 1429 0.459565702590667 2225 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_339 3091-4833 71.4 µM 0.10152074427599 0.435524741903498 no 1430 0.459568545539757 2159 3240077
SGTC_1199 1638-0010 4.46 µM 0.101064806119971 0.435724305255389 no 1431 0.459749507803627 2112 3111136
SGTC_2873 9040596 71.43 µM 0.0989012911960559 0.436671494307205 no 1432 0.460608321854037 2072 6463863
SGTC_2003 4023581 200 µM 0.0977145147247928 0.437191220872338 no 1433 0.461079494816089 2150 16641307
SGTC_1991 st073000 8.92 µM 0.0954923152524885 0.43816468244041 no 1434 0.461961896953979 2201 4301969 YIL048W NEO1
SGTC_316 k060-0003 58.6 µM 0.0950595271067809 0.438354314292917 no 1435 0.462133772568854 2212 6152314
SGTC_152 4469-0003 551.229 µM 0.0949361327641292 0.438408383751917 no 1436 0.462182778161985 2263 697280
SGTC_2117 5521686 200 µM 0.094879043744876 0.43843339965075 no 1437 0.462205451042796 2170 803312
SGTC_1886 st057356 49.9 µM 0.0942537416611592 0.438707417525585 no 1438 0.462453797534802 2067 24207747
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0940732656183377 0.438786510628193 no 1439 0.462525478563868 2244 23665772 A membrane-active detergent.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0939670581262159 0.438833056896492 no 1440 0.462567662362326 2207 23847180
SGTC_791 1348-1292 225 µM 0.0931327558875779 0.439198725782908 no 1441 0.462899047540348 2214 5437054
SGTC_3049 9092223 49.47 µM 0.0926934015935976 0.439391312602211 no 1442 0.463073569604207 2150 8623917
SGTC_2511 berberine 10.47 µM 0.0905290176128074 0.440340258503384 no 1443 0.4639334179494 2199 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2154 5570129 200 µM 0.0903428961621226 0.44042187710605 no 1444 0.464007366645403 2241 673366
SGTC_2806 7952793 58.44 µM 0.0885963354578827 0.441187907631622 no 1445 0.464701360257455 2192 2972490
SGTC_1745 st081495 74 µM 0.0880673505703447 0.441419960625546 no 1446 0.464911572996593 2200 13842402 YBL026W LSM2
SGTC_2791 5663188 71.43 µM 0.0862741315350084 0.442206752018272 no 1447 0.465624250915912 2231 54690634
SGTC_324 1315-0088 19.6 µM 0.0856773547288605 0.442468644072212 no 1448 0.465861452115004 2243 6787421
SGTC_863 0466-0191 129 µM 0.0848691427519613 0.44282336329266 no 1449 0.46618271188496 2268 765160 YPR165W RHO1
SGTC_2248 tofa 1.1 µM 0.084790691496751 0.442857797506707 no 1450 0.466213896999669 2129 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2444 5485484 36.41 µM 0.0846594233039172 0.44291541535817 no 1451 0.466266077809646 2210 6790631
SGTC_2739 tacrine 100.86 µM 0.084606032489883 0.442938850657082 no 1452 0.466287301516966 2191 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2803 7707263 71.43 µM 0.0845707294807026 0.442954346626598 no 1453 0.466301335083589 2180 2199229
SGTC_1655 st012546 55.1 µM 0.0843759462191324 0.443039846727506 no 1454 0.466378765606376 2216 720985 YLR208W SEC13
SGTC_2720 fluspirilene 36.88 µM 0.0837830529949365 0.443300113480122 no 1455 0.466614461194959 2228 3396 An atypical antipsychotic.
SGTC_927 2425-1185 123 µM 0.0816633342294263 0.444230821512348 no 1456 0.467457217991304 2264 730375
SGTC_1530 rhein 70.4 µM 0.0807823712626975 0.444617718002615 no 1457 0.467807513969225 2254 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2428 5615643 7.78 µM 0.0806333915669809 0.444683151316161 no 1458 0.467866755013145 2217 2253075
SGTC_2998 9066762 71.4286 µM 0.0802239862402459 0.444862973826717 no 1459 0.468029556690565 2228 4945196
SGTC_1771 st048882 4.1505 µM 0.0790256076441296 0.445389401013382 no 1460 0.468506127399985 2196 4580403
SGTC_1726 st035556 14.5795 µM 0.0770605013546673 0.446252846568143 no 1461 0.469287707439065 2249 5919439
SGTC_253 dyclonine 31.25 µM 0.0769608303046963 0.44629664773118 no 1462 0.469327352699602 2274 3180 An oral anasthetic.
SGTC_2096 5468907 200 µM 0.0765334090684835 0.446484488505382 no 1463 0.469497367658664 2252 759785
SGTC_656 4090-1979 187 µM 0.0755022929683792 0.44693768718393 no 1464 0.469907536610641 2270 22330961
SGTC_282 k297-0036 65.7 µM 0.0752700407894954 0.447039776815602 no 1465 0.469999928914792 2241 5061378
SGTC_2751 anetholtrithion 17.25 µM 0.0743162634171227 0.447459059471279 no 1466 0.470379368240017 2237 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2211 7117706 200 µM 0.0729942344612574 0.448040323351918 no 1467 0.470905352753242 2287 822771
SGTC_2236 dapsone 200 µM 0.0728604820822241 0.448099137246495 no 1468 0.470958570527282 2292 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2621 lithochol-11-enic acid 100 µM 0.0728281669767238 0.448113347087968 no 1469 0.47097142823048 2273 6708711
SGTC_2936 9038235 15.59 µM 0.072580486689985 0.448222261137724 no 1470 0.471069977562233 2281 4749415
SGTC_901 1112-0062 60.1 µM 0.072431832176455 0.44828763182043 no 1471 0.471129126451189 2287 1908457
SGTC_2038 4100038 30.985 µM 0.0717235444323259 0.448599119945243 no 1472 0.471410959333349 2211 3596803
SGTC_1648 st011736 69.8 µM 0.0692566942236885 0.449684228221333 no 1473 0.472392647965331 2263 2855514
SGTC_219 mitoxanthrone 164.414 µM 0.0689386276454653 0.449824165646775 no 1474 0.472519235614314 2251 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2900 5328528 85.29 µM 0.0685704179585396 0.449986171960562 no 1475 0.472665783237165 2263 795359
SGTC_2206 7254556 146.969 µM 0.0683297573340782 0.450092063253518 no 1476 0.472761568275903 2277 4398905
SGTC_3265 9137266 49.47 µM 0.0679601022777833 0.450254719345928 no 1477 0.472908697295461 2303 17224265
SGTC_2387 9077560 195.08 µM 0.0670968166038148 0.450634615915133 no 1478 0.473252314084154 2254 5303272
SGTC_137 0438-0332 85.389 µM 0.0665544608996552 0.450873307541801 no 1479 0.473468200126885 2280 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_88 0180-0332 8.668 µM 0.0663638303569439 0.450957208577723 no 1480 0.473544082944715 2293 3101745
SGTC_176 1486-1328 72.834 µM 0.0663578612739535 0.45095983574852 no 1481 0.473546459026681 2228 22310231
SGTC_2061 5245884 80.95 µM 0.066112952455898 0.451067629247932 no 1482 0.473643949422606 2271 573863
SGTC_3319 9138450 16.7555 µM 0.0658754198807601 0.451172179635292 no 1483 0.473738505079285 2161 2029690
SGTC_549 1661-1316 519 µM 0.0640359945653656 0.451981920112215 no 1484 0.474470783045897 2289 2857282
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0635399162816829 0.452200334984765 no 1485 0.474668287423512 2166 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_659 k018-0002 107 µM 0.0631405821458844 0.452376165559411 no 1486 0.474827279436171 2291 6797879 YHR007C ERG11
SGTC_2943 9068529 45.32 µM 0.0628811424845254 0.452490404289076 no 1487 0.474930575620361 2299 3270634
SGTC_2099 5377090 177.372 µM 0.0624348418372725 0.452686932471411 no 1488 0.475108274648927 2220 2243829
SGTC_1914 st062367 72.6 µM 0.0621541511757289 0.452810540351168 no 1489 0.475220036958 2248 978205
SGTC_603 3794-0023 45.9 µM 0.0617532215198214 0.452987105861951 no 1490 0.475379678081959 2288 3802260
SGTC_2798 7813637 45.45 µM 0.0616085376713149 0.453050825502242 no 1491 0.475437288891015 2247 956368
SGTC_2695 st077686 51.995 µM 0.0614016249673934 0.45314195320635 no 1492 0.47551967913335 2239 2876092
SGTC_590 k048-0076 22.4 µM 0.0610383627028107 0.453301945754063 no 1493 0.475664328489866 2302 6832814
SGTC_1156 4092-0367 4.88 µM 0.0609766404150301 0.453329131016546 no 1494 0.47568890633918 2206 1357585
SGTC_2229 7354935 190 µM 0.0585257036774922 0.454408808889707 no 1495 0.476664944503494 2301 318112
SGTC_220 paclitaxel 373.376 µM 0.0577153447643167 0.454765859807411 no 1496 0.47698768535829 2285 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2841 9004761 38.96 µM 0.0572728963032307 0.454960821745663 no 1497 0.477163905260105 2233 2991039
SGTC_10 0279-0212 42.575 µM 0.0564165532775034 0.455338194318416 no 1498 0.477504985174138 2307 39851 YBR002C RER2
SGTC_429 1112-0049 25.5 µM 0.055740823099803 0.455636003029191 no 1499 0.477774138954144 2175 2836170
SGTC_259 usnic acid 108.925 µM 0.0552143760563109 0.455868036761963 no 1500 0.47798383798527 2285 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3104 9120930 49.47 µM 0.0550232980662496 0.455952258911421 no 1501 0.478059951366877 2215 17014836
SGTC_2425 5628681 7.85 µM 0.0529476168268063 0.456867291314705 no 1502 0.478886822418617 2279 5714958
SGTC_118 0083-0097 135.343 µM 0.0524730371517672 0.457076534826911 no 1503 0.479075889482179 2320 5207356
SGTC_713 1488-1073 324 µM 0.0507333252144307 0.457843680043545 no 1504 0.479769010575746 2326 3312542
SGTC_2775 cyproheptadine 69.59 µM 0.0507317098822445 0.457844392415569 no 1505 0.479769654171279 2320 2913 A selective serotonin reuptake inhibitor.
SGTC_187 1488-2104 32.728 µM 0.0501579402783337 0.458097437101065 no 1506 0.479998264067677 2289 2852859
SGTC_2009 4012297 12.05 µM 0.0498550372470351 0.458231030682445 no 1507 0.48011895389744 2237 45595307
SGTC_1048 3161-0300 24.5 µM 0.0492691330186724 0.458489453636939 no 1508 0.480352408957374 2313 2165101
SGTC_952 1185-0122 232 µM 0.0491267762653262 0.458552245140673 no 1509 0.480409132395776 2317 678600
SGTC_1186 1319-0216 26 µM 0.0490979207812736 0.458564973003213 no 1510 0.480420630193546 2311 4565136
SGTC_265 mycophenolic acid 32.932 µM 0.0487312120840824 0.458726728201315 no 1511 0.480566750885298 2287 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3151 9099821 49.47 µM 0.0482442796603475 0.458941524640457 no 1512 0.480760780592907 2267 17174189
SGTC_1917 st066507 28.5 µM 0.0475858132451186 0.459232007493139 no 1513 0.481023169305703 2233 3156428
SGTC_2360 9040895 200 µM 0.0473767334583176 0.459324247726563 no 1514 0.481106486101867 2267 4914414
SGTC_2921 7974240 10.71 µM 0.0470700600318069 0.459459547541244 no 1515 0.481228694755846 2287 2979074 YDR527W RBA50
SGTC_1845 st056753 3.01 µM 0.0460498820898069 0.459909668779495 no 1516 0.481635245946804 2317 5375839
SGTC_2851 9015922 71.43 µM 0.0458121346497454 0.460014574719386 no 1517 0.48172999345735 2306 2996893
SGTC_990 3985-0011 41.3 µM 0.0453878460207466 0.460201798778165 no 1518 0.481899084237636 2287 5399565 YGL099W LSG1
SGTC_676 falcarinol 140 µM 0.0450546126814562 0.460348849441132 no 1519 0.482031889245423 2333 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_296 1222-0039 74.9 µM 0.0448297805050749 0.460448067430718 no 1520 0.482121493769023 2285 5984176
SGTC_1635 st007035 42.4 µM 0.0445453206677668 0.460573602515852 no 1521 0.482234863569835 2326 3716403
SGTC_655 k060-0012 42 µM 0.0441477194111075 0.460749074668332 no 1522 0.482393327625378 2286 5994525
SGTC_680 0417-1641 114 µM 0.0437776292714545 0.460912412292213 no 1523 0.482540829620123 2297 2835990
SGTC_617 3770-0098 35 µM 0.0437681548831922 0.460916593857686 no 1524 0.482544605734806 2284 5962639
SGTC_78 0336-0123 156.75 µM 0.0416191974552573 0.461865157006685 no 1525 0.483401134572142 2204 6765896
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0395637903083608 0.462772629555451 no 1526 0.484220447985452 2341 88881 An O-methylated flavonoid and antioxidant.
SGTC_138 0850-0259 40.9225 µM 0.0388939533195685 0.463068408036249 no 1527 0.484487468737501 2340 6813004
SGTC_2020 4017018 200 µM 0.0388544379506836 0.463085857392235 no 1528 0.484503221181805 2307 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1295 1013-0063 9.78 µM 0.0384854187084302 0.463248813822015 no 1529 0.484650328528391 2338 6826038
SGTC_2699 st077704 54.6 µM 0.0370292776318499 0.463891895903576 no 1530 0.485230830784267 2309 645852
SGTC_2796 7949634 45.45 µM 0.0370010504507034 0.463904362937193 no 1531 0.485242084088439 2325 2971588
SGTC_2171 5739187 198.077 µM 0.0360623314187625 0.464318984908708 no 1532 0.485616328975669 2338 2262761
SGTC_1647 st011722 22.4 µM 0.0354574754593611 0.46458616375454 no 1533 0.485857477351712 2328 2854783
SGTC_1371 2421-0008 32.7 µM 0.0354104844317833 0.464606921446668 no 1534 0.485876212294231 2308 2827552
SGTC_3251 9135047 49.47 µM 0.0348656999232908 0.464847580130597 no 1535 0.486093415735322 2345 17682963
SGTC_1679 SEC14.276 6.7 µM 0.0344092014782068 0.465049248331223 no 1536 0.48627542304976 2340 1005053 YMR079W SEC14
SGTC_2251 lansoprazole 556 µM 0.0338188462841154 0.465310063991345 no 1537 0.486510803689798 2269 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1273 0849-0096 14.1 µM 0.0333830330703837 0.465502613427029 no 1538 0.486684569885018 2303 5286025
SGTC_1263 0774-1208 64.8 µM 0.0332030496697441 0.465582135408622 no 1539 0.486756333090061 2338 906585
SGTC_3029 9088683 49.47 µM 0.0325995282019436 0.465848799028959 no 1540 0.486996973036046 2309 25236615
SGTC_2776 terbinafine 19.92 µM 0.0325353053145484 0.465877176567526 no 1541 0.48702258067739 2341 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1121 fusaric acid 630.51 nM 0.0314868438473588 0.466340474405403 no 1542 0.487440642016417 2300 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1982 st072467 71.9 µM 0.0314693416598047 0.466348208722382 no 1543 0.487447620920581 2299 3163533
SGTC_16 erodoxin 22.806 µM 0.0314134080943102 0.4663729261707 no 1544 0.487469924157978 2347 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3024 9090631 49.47 µM 0.0310999472456065 0.466511449190957 no 1545 0.487594915871154 2357 25236383
SGTC_1042 0350-0096 82 µM 0.0300902566088153 0.466957674024786 no 1546 0.487997535656905 2346 3122515
SGTC_1135 dihydrocapsaicin 536.708 nM 0.0289621910392774 0.46745626282495 no 1547 0.488447372557644 2340 107982 A Capsaicinoid.
SGTC_890 0929-0006 47.2 µM 0.0287624872838701 0.46754453436252 no 1548 0.488527009651962 2331 1378169
SGTC_469 w7 172 µM 0.0286474683874999 0.467595374866328 no 1549 0.488572876652202 2347 45115570 A P450 inhibitor.
SGTC_1880 MG-132 525 µM 0.028432465049516 0.467690411780631 no 1550 0.488658615648396 2348 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_6 0844-0013 19.835 µM 0.0281191986434011 0.467828886751853 no 1551 0.48878354091204 2358 1584900
SGTC_569 4130-2812 160 µM 0.0279562625160025 0.467900911895819 no 1552 0.488848517477668 2372 743552
SGTC_2271 7849410 118.62 µM 0.0276474068149712 0.468037442978583 no 1553 0.488971685464808 2364 972430
SGTC_3270 9137563 49.47 µM 0.0261153668915316 0.468714743538737 no 1554 0.489582660118038 2335 17015724
SGTC_856 0433-0016 11.3 µM 0.0260122122133297 0.46876035053558 no 1555 0.489623798904979 2271 3911780
SGTC_3143 9086658 49.47 µM 0.0258910385611543 0.46881392464853 no 1556 0.4896721239222 2303 25236626
SGTC_2908 7930301 100 µM 0.0252278223548378 0.469107160252345 no 1557 0.489936622492583 2363 2223178
SGTC_867 0518-0118 155 µM 0.0247562975131333 0.469315651294314 no 1558 0.490124674948216 2362 6848158
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0246904979888883 0.469344746108032 no 1559 0.490150917139015 2362 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3334 9142812 21.919 µM 0.0230427234690484 0.470073401502441 no 1560 0.490808096792835 2335 45283678
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0223538713760286 0.470378045717284 no 1561 0.491082838227997 2345 5379071
SGTC_2934 9036370 36.88 µM 0.0218452756379719 0.470602982858487 no 1562 0.491285689028037 2352 6462800
SGTC_2895 9054447 58.44 µM 0.0218117050725285 0.470617830476525 no 1563 0.491299078555648 2349 2697450
SGTC_2927 9011802 47.9 µM 0.0205069297094997 0.471194939070222 no 1564 0.491819492065526 2342 43912568
SGTC_179 1273-0063 6.77 µM 0.0202780010690426 0.471296201612152 no 1565 0.491910802391405 2365 3108139
SGTC_60 0986-0278 202 µM 0.0195088672022238 0.471636427951146 no 1566 0.492217581692843 2333 3110598
SGTC_2086 5274770 176.623 µM 0.0182489421084338 0.472193800385907 no 1567 0.492720129484387 2355 689278
SGTC_772 k072-0172 35.3 µM 0.0164403737622714 0.472993979488217 no 1568 0.493441535245372 2364 5861980
SGTC_92 0063-0024 660.874 µM 0.0162272398301883 0.473088285249772 no 1569 0.493526552040397 2375 3594437
SGTC_2254 7938975 95.19 µM 0.0161140854326264 0.473138353496785 no 1570 0.493571688212052 2375 2969277
SGTC_504 lovastatin 124 µM 0.0156471280529047 0.473344975996024 no 1571 0.493757953763299 2365 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3137 9097352 49.47 µM 0.0155351403591385 0.473394530145994 no 1572 0.493802624959459 2361 44120435
SGTC_503 tyrphostin 8 294 µM 0.0153808092968757 0.473462821758079 no 1573 0.493864186789806 2364 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2112 5488546 200 µM 0.014195680147601 0.473987268147448 no 1574 0.494336933191727 2380 600757
SGTC_3328 9140624 29.0385 µM 0.0136689773471829 0.474220360546005 no 1575 0.494547036813018 2379 4904392
SGTC_589 1227-0070 34.1 µM 0.0136390785302373 0.474233592537123 no 1576 0.494558963603408 2371 2841384
SGTC_913 3487-1245 167 µM 0.0133275647117644 0.474371457475413 no 1577 0.494683228339849 2371 4016153
SGTC_189 3970-0742 2.116 µM 0.0131932664122801 0.47443089407473 no 1578 0.494736800899389 2386 2891807
SGTC_2238 6671620 73.2395 µM 0.0129749163435861 0.474527530805552 no 1579 0.494823902517614 2378 729941
SGTC_188 3229-0966 278.469 µM 0.0129690497914377 0.474530127227638 no 1580 0.494826242736401 2386 5722370
SGTC_3044 9093193 49.47 µM 0.0126163461581002 0.47468622899183 no 1581 0.494966939614249 2370 25236277
SGTC_1874 staurosporine 7.6 µM 0.0125332547338514 0.474723004676838 no 1582 0.495000085675787 2379 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2007 4011539 71.82 µM 0.012202388581669 0.474869445861993 no 1583 0.495132072077539 2381 45595301
SGTC_3269 9137823 49.47 µM 0.0117811977070963 0.475055869631296 no 1584 0.495300090843039 2385 17682936
SGTC_2813 7971799 71.43 µM 0.0110607358397338 0.47537476671139 no 1585 0.495587494792253 2367 2234054
SGTC_866 0495-0101 262 µM 0.00971822665641317 0.475969041699618 no 1586 0.496123049522068 2376 635694
SGTC_355 1311-2252 105 µM 0.00822221759360219 0.476631327847225 no 1587 0.496719846722345 2385 5338538
SGTC_695 3505-6186 243 µM 0.00811667812011941 0.476678052838389 no 1588 0.496761949475559 2391 1819379
SGTC_1788 fluconazole 20 µM 0.00787552236349945 0.476784819786587 no 1589 0.496858153627223 2352 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_396 dithiazanine 1.25 µM 0.00683572279929598 0.4772451894941 no 1590 0.497272962396036 2383 10578 An antihelmenthic.
SGTC_2513 baicalein 25.65 µM 0.00627144179220731 0.477495036820692 no 1591 0.497498073110563 2393 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3303 9125618 40.5795 µM 0.00355328943502532 0.478698678338808 no 1592 0.498582445592841 2389 22695467
SGTC_1473 k844-0725 134 µM 0.00259836603730624 0.479121580439132 no 1593 0.498963403094191 2399 54682906
SGTC_2854 9024559 71.43 µM 0.00171681642981147 0.479512008736515 no 1594 0.499315089674918 2403 3163529
SGTC_3100 9120536 49.47 µM 0.0015659271719597 0.479578837853834 no 1595 0.499375285698389 2402 16421196
SGTC_2872 9044037 25.97 µM 0.000703927396193624 0.479960630019223 no 1596 0.499719173622518 2400 6465195
SGTC_2553 4-methylesculetin 85.09 µM 0.000420421131017884 0.480086203078503 no 1597 0.499832276240204 2399 5319502
SGTC_327 1273-0057 3.96 µM 0 0.480272423294993 no 1598 0.5 2405 3108138
SGTC_2962 9082311 13.18 µM 0 0.480272423294993 no 1599 0.5 2406 16459453
SGTC_1054 3429-0080 167 µM -3.51454276054809e-05 0.480287990712697 no 1600 0.499985979002968 2406 1162877
SGTC_2067 5224629 34.075 µM -0.00123124991453051 0.480817814472442 no 1601 0.49950880247546 2413 2835000
SGTC_732 3970-1727 52.7 µM -0.00220489092487656 0.481249121371999 no 1602 0.499120376499115 2408 1275699
SGTC_2842 9000675 19.48 µM -0.00342387362636071 0.48178914147572 no 1603 0.498634074716464 2409 2989072
SGTC_623 k072-0108 16.9 µM -0.00358241330400763 0.481859378430029 no 1604 0.498570826924086 2413 5382803
SGTC_2783 7738165 71.43 µM -0.00474369244370463 0.482373870515872 no 1605 0.49810754761651 2416 17201110
SGTC_827 3253-0474 693 µM -0.00589715806285229 0.482884929967927 no 1606 0.497647387950451 2421 5402065
SGTC_1172 0370-0043 85 µM -0.00691925726367095 0.483337809175601 no 1607 0.497239637754471 2427 376585
SGTC_3335 9143315 29.6265 µM -0.00749248809723272 0.483591809943021 no 1608 0.497010957678802 2427 4899691
SGTC_72 0744-0168 198.391 µM -0.0078240507433869 0.483738729661755 no 1609 0.496878687200084 2439 677577
SGTC_2152 5568786 200 µM -0.00789750477463628 0.483771278397334 no 1610 0.496849384186716 2419 5399883
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0080951622058724 0.483858864316841 no 1611 0.496770532801461 2421 140250 A respiratory chain inhibitor.
SGTC_3305 9127027 53.8275 µM -0.009212461004899 0.484353976048249 no 1612 0.496324811783863 2423 41905295
SGTC_1045 1348-1485 165 µM -0.00949805702967434 0.484480536912585 no 1613 0.496210880440647 2428 6810614
SGTC_2729 fluphenazine 10.66 µM -0.00984638221865261 0.484634898098386 no 1614 0.496071925296043 2428 3372 An atypical antipsychotic.
SGTC_1526 st051518 75 µM -0.0108055427076225 0.485059964318039 no 1615 0.495689296037531 2455 673993
SGTC_1807 st050092 58.9 µM -0.0110462494029154 0.485166639749706 no 1616 0.495593273691349 2422 5008496
SGTC_1887 st057648 70.8 µM -0.0112935599939249 0.485276242975091 no 1617 0.495494617195174 2426 688672
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0118815883776295 0.485536850125419 no 1618 0.495260043563067 2432 5282309
SGTC_2982 9019404 25.97 µM -0.0121684589896156 0.48566399000021 no 1619 0.495145607021463 2436 22333232
SGTC_1195 1502-0147 41.1 µM -0.0122562479091581 0.485702897979929 no 1620 0.495110586921292 2417 817940
SGTC_206 4546-0025 72.014 µM -0.0126211435784582 0.485864620906428 no 1621 0.494965025872802 2435 6620745 YIL048W NEO1
SGTC_537 1334-0398 209 µM -0.0127196347484834 0.485908272907227 no 1622 0.49492573673469 2430 5846986
SGTC_1339 1486-1321 22.7 µM -0.0129393879504973 0.486005669727883 no 1623 0.494838075106019 2435 3469382
SGTC_691 1548-0686 185 µM -0.0133644429885073 0.486194060742825 no 1624 0.494668517346217 2444 46495133
SGTC_2817 7995342 71.43 µM -0.0136698596858065 0.486329428086081 no 1625 0.49454668484372 2434 18879975
SGTC_309 k408-0051 1.48 µM -0.01431130184493 0.486613734354407 no 1626 0.494290811493483 2435 3640463
SGTC_3108 9121785 49.47 µM -0.0152650422527164 0.487036473043013 no 1627 0.493910365736829 2428 17140271
SGTC_2325 6158266 200 µM -0.015699492126697 0.487229044733841 no 1628 0.493737066086006 2458 3623240
SGTC_1064 honokiol 6.76 µM -0.0159328513672075 0.487332483407714 no 1629 0.493643980862077 2448 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_811 0416-0114 265 µM -0.0194185018435602 0.488877628284736 no 1630 0.492253625427125 2473 6612453
SGTC_2765 myclobutanil 7.74 µM -0.0199307375688973 0.489104710544238 no 1631 0.492049312488631 2469 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2571 chrysanthemic acid 100 µM -0.021130901761628 0.489636776158422 no 1632 0.491570617176604 2468 2743 An insecticide.
SGTC_805 3852-0218 479 µM -0.0216773055168331 0.489879018055039 no 1633 0.491352683546494 2443 6615355
SGTC_1583 clindamycin 39.6 µM -0.0218563300674421 0.489958387371801 no 1634 0.491281280001423 2453 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2347 9049783 174.81 µM -0.0229126041883217 0.490426687307995 no 1635 0.490859993173622 2462 6467988 YPL169C MEX67
SGTC_1144 3486-0183 12.5 µM -0.0230980051776445 0.490508886357616 no 1636 0.49078604845025 2465 6744069
SGTC_2424 5537928 59.2 µM -0.0238442800455006 0.490839757483702 no 1637 0.490488409854596 2449 5382802
SGTC_1950 st077106 7.18 µM -0.0245249550218182 0.491141549506797 no 1638 0.490216939235184 2494 13831864
SGTC_2394 5221648 200 µM -0.0248233442471405 0.491273848454604 no 1639 0.490097935388726 2471 788586
SGTC_980 1473-0395 201 µM -0.024969236451205 0.491338534066504 no 1640 0.490039750855112 2447 768876
SGTC_2892 9047358 58.44 µM -0.0264778818269955 0.492007449538833 no 1641 0.489438087579294 2469 6466771
SGTC_2110 5483698 200 µM -0.0266810211080717 0.492097520846004 no 1642 0.489357075352698 2467 2848765 YHR062C RPP1
SGTC_2429 5902844 64.44 µM -0.027162282687859 0.492310912290125 no 1643 0.489165149326669 2483 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2686 alizarin 95.37 µM -0.0277565299118875 0.492574404612367 no 1644 0.488928168348402 2481 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2322 7413319 38.22 µM -0.0285629201412131 0.492931967410623 no 1645 0.488606592725339 2499 1840400
SGTC_843 0310-0051 143 µM -0.0293967943148767 0.493301722878496 no 1646 0.488274064733726 2471 2065037
SGTC_2380 9035439 200 µM -0.029796991389648 0.493479179840105 no 1647 0.488114479113073 2562 6462575
SGTC_3115 9123671 49.47 µM -0.0300388798710334 0.493586439610279 no 1648 0.488018022748822 2451 3286988
SGTC_439 amiodarone 34.4 µM -0.0303679300546639 0.493732349934639 no 1649 0.487886810581307 2518 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1426 4048-4480 71.7 µM -0.0304182076044672 0.493754644521987 no 1650 0.487866762002899 2465 14224343
SGTC_234 nsc-17383 10.7 µM -0.0304236547145937 0.493757059936658 no 1651 0.487864589925653 2469 408974
SGTC_1128 3448-9350 235 µM -0.0311479018643817 0.494078215203473 no 1652 0.487575794010089 2524 619386
SGTC_363 0455-0021 3.06 µM -0.0312215658948039 0.494110880502369 no 1653 0.487546420599928 2473 4597466
SGTC_2457 5731572 11.68 µM -0.031357706394154 0.494171250233992 no 1654 0.487492134979143 2457 2865357
SGTC_426 0988-0037 14.6 µM -0.0322377805126028 0.494561510801534 no 1655 0.48714121366723 2459 5383008
SGTC_1922 5578187 25 µM -0.0333176373530717 0.495040370205897 no 1656 0.486710644496897 2466 1350412
SGTC_2823 7987624 58.44 µM -0.0333619286799648 0.495060011224466 no 1657 0.486692984631507 2497 2239440
SGTC_3153 9100258 49.47 µM -0.0347488660607629 0.495675055349975 no 1658 0.486139997476309 2500 25236848
SGTC_3237 9133362 49.47 µM -0.0353106396097778 0.495924179569772 no 1659 0.485916019720418 2463 43845137
SGTC_546 peri-Naphthalide 147 µM -0.0376225951744711 0.496949455554988 no 1660 0.484994296164718 2519 223824 A penicillin ester.
SGTC_334 1502-1024 68.5 µM -0.0377874028887062 0.497022543186079 no 1661 0.484928594119264 2558 3296216
SGTC_3102 9121669 49.47 µM -0.0384830760053646 0.497331055909886 no 1662 0.484651262439859 2493 41905072
SGTC_710 3448-4187 58 µM -0.0386129781506254 0.497388664275928 no 1663 0.48459947747108 2487 3946412
SGTC_1458 k015-0034 6.33 µM -0.0388592621450772 0.497497885241948 no 1664 0.484501298059059 2499 3598957
SGTC_2471 5466956 24.79 µM -0.0393164980603914 0.497700658749149 no 1665 0.484319026617946 2538 724419
SGTC_2359 9039622 200 µM -0.0394014074738175 0.497738314168588 no 1666 0.48428517889031 2497 6463596
SGTC_1935 st074532 41.6 µM -0.0396950126229169 0.497868521616732 no 1667 0.484168138947609 2608 2829742
SGTC_2719 novobiocin 32.65 µM -0.0411631656283655 0.498519618423418 no 1668 0.483582909169974 2488 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1194 1488-0194 225 µM -0.0422828072618966 0.49901616007535 no 1669 0.483136625422922 2474 1391452
SGTC_616 4092-0450 108 µM -0.042513835307964 0.499118617223194 no 1670 0.483044541370757 2516 787165
SGTC_2401 5128683 200 µM -0.0425870256104909 0.499151075933943 no 1671 0.483015369085309 2498 708373
SGTC_2926 9010726 65.15 µM -0.042602995971108 0.499158158530314 no 1672 0.483009003610398 2533 2994293
SGTC_1476 4112-3294 3.34 µM -0.0427389780142772 0.499218464375407 no 1673 0.482954803990202 2564 704369
SGTC_1230 0170-0365 3.77 µM -0.0430249342456962 0.499345281413096 no 1674 0.482840828800055 2537 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3129 9127257 49.47 µM -0.0432866355653798 0.499461341841741 no 1675 0.482736522255722 2506 837894
SGTC_696 1560-0013 611 µM -0.043507878611226 0.499559459696769 no 1676 0.482648342125563 2537 1650269
SGTC_2968 9090663 33.37 µM -0.0435665332316825 0.499585472114775 no 1677 0.482624964484051 2583 25236811
SGTC_2917 7979103 53.79 µM -0.0444567473584849 0.499980268479107 no 1678 0.482270164236803 2513 2980565
SGTC_1731 st035964 63 µM -0.0445457313356316 0.499980268479107 no 1679 0.482234699899527 2544 6739575
SGTC_2488 5268135 45.7 µM -0.0449399777632325 0.499805426186533 no 1680 0.482077575685707 2518 1270356 YLR208W SEC13
SGTC_2652 actinonin 100 µM -0.0453971249600366 0.499602688408818 no 1681 0.481895386288171 2487 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_485 niflumic acid 177 µM -0.0461924328986189 0.49924998179847 no 1682 0.481578436855301 2566 4488 A COX2 inhibitor.
SGTC_2136 5328288 199.296 µM -0.0463289655279003 0.4991894317678 no 1683 0.481524026468565 2494 262395
SGTC_128 0906-2981 13.371 µM -0.0465729734528563 0.49908121821516 no 1684 0.481426786354533 2505 6740226
SGTC_3197 9113331 49.47 µM -0.0468380426707427 0.498963664397954 no 1685 0.481321154312553 2524 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2242 6630449 61.2675 µM -0.0471501158495379 0.498825265217046 no 1686 0.481196792526291 2652 691249 YDR170C SEC7
SGTC_686 1319-0111 510 µM -0.0471683156625884 0.498817193911728 no 1687 0.481189539920722 2497 4562600
SGTC_530 4358-1714 28 µM -0.0473041503285169 0.498756953579805 no 1688 0.481135410151919 2595 1564641
SGTC_82 0054-0107 293.755 µM -0.0476238605123947 0.498615167740841 no 1689 0.481008007831493 2583 3104697
SGTC_2419 paclitaxel 166.5 µM -0.0482649903439097 0.498330838491021 no 1690 0.480752527839483 2463 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_475 α-linolenic acid 10 µM -0.0484278939181866 0.498258593891173 no 1691 0.480687614623871 2571 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1627 st003713 25.6 µM -0.0484675039766925 0.498241027601126 no 1692 0.480671831031141 2533 16195070 YER133W GLC7
SGTC_2408 sulbentine 18.36 µM -0.049299208048625 0.497872183872086 no 1693 0.480340425318889 2621 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1728 st035614 33.7865 µM -0.0506118579653367 0.49729005433127 no 1694 0.47981740682336 2622 15945546
SGTC_1100 amiodarone 5.07 µM -0.0513997602646488 0.49694064077905 no 1695 0.479503487901716 2504 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_105 0111-0055 734.78 µM -0.0514618295193969 0.496913114824392 no 1696 0.47947875857942 2577 5179370
SGTC_441 propafenone 146 µM -0.0517185413813462 0.496799270549595 no 1697 0.479376481562249 2485 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2950 9072895 21.46 µM -0.0518019910561689 0.496762263091723 no 1698 0.479343234525016 2531 17332245
SGTC_2973 9094665 17.96 µM -0.0518755381223085 0.496729647170441 no 1699 0.479313932887724 2555 25237061 YIL048W NEO1
SGTC_1329 1447-1697 50.6 µM -0.0519682470654899 0.496688533561714 no 1700 0.479276997191258 2604 2840515
SGTC_1406 3909-7906 11.9 µM -0.0522190824243759 0.496577295853841 no 1701 0.479177064050252 2509 X1406
SGTC_1605 st000082 49.1 µM -0.0534104219678022 0.4960489774689 no 1702 0.478702450768594 2625 1114022
SGTC_455 paf C-16 10 µM -0.0539835946929466 0.495794797359817 no 1703 0.478474117359789 2496 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0540248226040427 0.49577651442788 no 1704 0.478457693769718 2522 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_565 1418-0001 44.5 µM -0.0552964567032022 0.495212600037854 no 1705 0.477951142495246 2565 2862145
SGTC_257 daunorubicin 18.5 µM -0.0554371150855972 0.495150224732843 no 1706 0.477895113862663 2623 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1981 st071826 47 µM -0.0557608811599984 0.495006650325329 no 1707 0.477766149371962 2565 11838600
SGTC_1413 3910-0535 34.4 µM -0.0567116667866463 0.494585027243441 no 1708 0.477387440111368 2575 2876951
SGTC_1150 3909-7983 10.9 µM -0.0569392606118804 0.494484102312464 no 1709 0.477296789791123 2517 23965914
SGTC_1508 1080-0625 72.9 µM -0.0570303384341251 0.494443714571345 no 1710 0.477260513943564 2478 767111
SGTC_2963 9082507 9 µM -0.0576228255049547 0.494180982266979 no 1711 0.477024533877624 2584 16459611
SGTC_1984 st072354 53.1 µM -0.0580740794472412 0.49398088002969 no 1712 0.476844810571035 2536 5762938
SGTC_1611 st001856 99.4 µM -0.0589496911754544 0.493592606644391 no 1713 0.476496089501609 2519 647478
SGTC_1961 st076550 68.7 µM -0.0596399684314161 0.493286520570324 no 1714 0.476221192401641 2581 1579337
SGTC_2155 5570423 76 µM -0.0598708175723292 0.493184157202596 no 1715 0.476129261195443 2528 797402
SGTC_2809 7964133 12.99 µM -0.060203071965049 0.493036829401538 no 1716 0.47599694954031 2538 1253665
SGTC_2015 5119600 184 µM -0.060807033708198 0.492769023934955 no 1717 0.475756444300199 2558 2828786
SGTC_3199 9111318 49.47 µM -0.0617356528041288 0.492357267051934 no 1718 0.4753866736379 2564 8548020
SGTC_1408 3909-7976 48.8 µM -0.0639379045667754 0.491380804960462 no 1719 0.474509835265385 2544 24152374
SGTC_1699 st031318 29.054 µM -0.0663417242661831 0.49031502830252 no 1720 0.47355288260654 2598 5340658
SGTC_2688 kanamycin b 96.69 µM -0.0664037221746199 0.490287541297758 no 1721 0.473528203439526 2557 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2278 7948257 134.34 µM -0.0669267146466635 0.490055672476279 no 1722 0.47332002275048 2523 1247028
SGTC_1278 0874-0585 172 µM -0.0670700798420377 0.489992112070594 no 1723 0.473262956535385 2564 766306
SGTC_3249 9135183 49.47 µM -0.0675082404084109 0.489797856857837 no 1724 0.473088551047818 2671 4902779
SGTC_2261 9010538 184.68 µM -0.0677568828951692 0.489687624142714 no 1725 0.472989583652951 2625 6457250
SGTC_2905 7799065 20.05 µM -0.0681409892898252 0.489517336652377 no 1726 0.472836700715271 2558 1296806
SGTC_3098 9119039 49.47 µM -0.0682684151635907 0.48946084482874 no 1727 0.472785983249757 2520 17161528
SGTC_2353 9059630 146.67 µM -0.0685997811467848 0.489313941051309 no 1728 0.472654096538859 2584 4779114
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.0687755875427175 0.489236001762575 no 1729 0.472584125191628 2595 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_847 0342-0274 5.54 µM -0.0696152396512029 0.488863769103032 no 1730 0.472249953440944 2545 18097
SGTC_2356 9061756 188.97 µM -0.0700942587603957 0.488651415767554 no 1731 0.472059318155023 2523 20104043
SGTC_1838 st055369 84.5 µM -0.0700984664133574 0.488649550492582 no 1732 0.472057643663221 2517 676036
SGTC_2277 7947813 106.88 µM -0.0701209382272292 0.488639588621991 no 1733 0.472048700712538 2755 1246798
SGTC_971 1315-0384 26.7 µM -0.071953030626093 0.487827437049497 no 1734 0.471319643520915 2574 6769120
SGTC_1602 st001878 87.6 µM -0.0719961829438751 0.487808308575277 no 1735 0.471302472769704 2707 595405 YLR310C CDC25
SGTC_1609 st001574 46.4 µM -0.0720150458229498 0.487799947084293 no 1736 0.471294967052807 2548 3960012
SGTC_1381 2324-0066 62.1 µM -0.0728720860146642 0.487420046114963 no 1737 0.470953953501336 2603 10885928
SGTC_2620 irigenin 100 µM -0.0735686945595736 0.487111268218574 no 1738 0.47067679086786 2606 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1468 k284-1086 134 µM -0.073931390752338 0.486950502971414 no 1739 0.470532488990436 2564 15996457
SGTC_1410 3909-8106 77.9 µM -0.0754879880876238 0.486260564922754 no 1740 0.46991322719248 2577 1039210
SGTC_1784 st039334 36.3 µM -0.0762544282204637 0.485920866994098 no 1741 0.469608340620275 2730 3496984
SGTC_997 3996-0078 137 µM -0.0768568508821941 0.485653871262658 no 1742 0.469368711986987 2585 735687
SGTC_3216 9129716 49.47 µM -0.0770169622848444 0.485582910432233 no 1743 0.469305025547345 2570 8056934
SGTC_1916 st067606 49.2 µM -0.0777507248440413 0.485257715230019 no 1744 0.469013171802689 2625 19590279
SGTC_625 k213-0058 121 µM -0.0795179631552413 0.484474536013609 no 1745 0.468310322160739 2593 3655420
SGTC_3084 9116877 49.47 µM -0.0800797962928861 0.484225563300028 no 1746 0.468086895678631 2534 27241325
SGTC_23 0213-0011 39.996 µM -0.0809743902385261 0.483829142523155 no 1747 0.467731159618911 2607 627608
SGTC_3279 9140807 49.47 µM -0.0811808657812207 0.483737649419292 no 1748 0.467649058089722 2540 45595718
SGTC_2781 5567276 71.43 µM -0.0813689552323819 0.483654304275335 no 1749 0.467574268678518 2658 2853274
SGTC_682 0kpi-0099 17 µM -0.0829459542074262 0.482955541773143 no 1750 0.466947256867871 2623 1714895 YML126C ERG13
SGTC_1258 0671-0043 57.1 µM -0.0829600808344562 0.482949282549532 no 1751 0.466941640515979 2609 4298767
SGTC_953 1188-0045 9.7 µM -0.0840273577710825 0.482476405920525 no 1752 0.466517340163183 2646 6144426
SGTC_1277 0873-0036 22 µM -0.08410662096602 0.48244128788288 no 1753 0.466485830264709 2623 5965735
SGTC_2482 5981709 142.65 µM -0.084301852771521 0.482354789832923 no 1754 0.466408219674691 2621 877755
SGTC_2846 9008642 19.48 µM -0.0850298182447338 0.482032269853315 no 1755 0.466118842507742 2673 2992898
SGTC_3203 9113543 49.47 µM -0.085943412030041 0.481627525220389 no 1756 0.465755700672718 2694 17018012
SGTC_424 splitomicin 100 mM -0.0861326430686929 0.481543693545669 no 1757 0.465680487311611 2654 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3060 1327-0027 12.5 µM -0.0863771217888733 0.481435387678201 no 1758 0.465583316557453 2602 16000455 YPR107C YTH1
SGTC_2521 angolensin 13.4 µM -0.0864271641754857 0.481413218702309 no 1759 0.465563426913735 2658 821428 A flavenoid.
SGTC_1205 4161-2785 76 µM -0.0873714458900749 0.480994909006488 no 1760 0.465188132720605 2701 3498106
SGTC_2320 7373003 200 µM -0.087886213083207 0.480766879796218 no 1761 0.464983557282848 2597 5415828
SGTC_2649 anisomycin 9.56 µM -0.0890505981715575 0.480251109162806 no 1762 0.464520849143453 2608 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_452 diindolylmethane 8 µM -0.0896571350486635 0.479982453434835 no 1763 0.464279839987439 2642 3071 Inhibits expression of several cancer promoting factors.
SGTC_417 st075190 100 µM -0.0905093182255027 0.479605008030141 no 1764 0.463941244736868 2560 222757
SGTC_1360 1598-0022 39.8 µM -0.0905431162286009 0.47959003873491 no 1765 0.463927816419824 2653 761525
SGTC_3329 9141233 27.5565 µM -0.0908627236810966 0.479448484510524 no 1766 0.46380083490992 2671 4909101 YNL103W MET4
SGTC_1158 4092-0494 91.8 µM -0.0910495241931518 0.479365751713862 no 1767 0.46372661991452 2688 1148199
SGTC_2616 abietic acid 100 µM -0.0915863078392128 0.479128018501981 no 1768 0.463513365242757 2580 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1889 st059080 5.18 µM -0.0919087592789094 0.478985213288638 no 1769 0.463385266011488 2548 176925 Isolated from Daphnopsis sellowiana.
SGTC_2260 7964312 200 µM -0.0924789380122931 0.478732702823697 no 1770 0.463158762266372 2769 231951
SGTC_2856 9022925 19.48 µM -0.0944764395049405 0.477848153420231 no 1771 0.462365348635907 2683 4944862
SGTC_1118 chelidonine 707.474 nM -0.094485307427317 0.477844226696794 no 1772 0.462361826601822 2574 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_379 3970-0972 5.9 µM -0.0946826900526382 0.477756826062843 no 1773 0.462283433769064 2613 2898042 YBL034C STU1
SGTC_116 0155-0182 31.788 µM -0.0958214562131335 0.477252603692113 no 1774 0.461831188087955 2589 771486
SGTC_2141 5621638 7.665 µM -0.0967390505546256 0.47684633813463 no 1775 0.461466813696281 2693 2856238
SGTC_305 1682-2595 20.8 µM -0.0972235179939496 0.476631849505872 no 1776 0.461274445928565 2630 226033
SGTC_3011 9081274 71.4286 µM -0.097761428134262 0.476393708084636 no 1777 0.461060868253429 2620 6625322
SGTC_3116 9124943 49.47 µM -0.0978029993390618 0.476375304197351 no 1778 0.461044362838223 2586 41905195 YPL160W CDC60
SGTC_1839 st053978 48 µM -0.0982755808733186 0.47616609232433 no 1779 0.460856733971655 2562 3788398
SGTC_1625 st003711 30.1 µM -0.0988913646755368 0.475893494665562 no 1780 0.460612262644155 2670 24207034 YER133W GLC7
SGTC_2595 hexamethylquercetagetin 100 µM -0.100213885991815 0.47530807389253 no 1781 0.460087261042265 2671 386331
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.100345256725759 0.475249924860022 no 1782 0.460035114554724 2772 94937 An inhibitor of serotonin biosynthesis.
SGTC_2339 9000433 200 µM -0.100516049939006 0.475174326922493 no 1783 0.459967320679631 2644 2988954
SGTC_2875 9039966 71.43 µM -0.100932379725859 0.474990051258814 no 1784 0.459802069522837 2681 6463691
SGTC_1235 benzylparaben 21.5 µM -0.101346723182827 0.474806660095118 no 1785 0.459637613681676 2647 7180
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.102692672165951 0.474210971175926 no 1786 0.45910344483052 2563 4000243
SGTC_2468 5987765 72.9 µM -0.103167787673006 0.474000708671263 no 1787 0.458914902586386 2668 26772094
SGTC_903 1134-0042 114 µM -0.103486531660655 0.4738596524832 no 1788 0.45878841913941 2603 701009
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.105024070474982 0.473179280149007 no 1789 0.4581783544316 2656 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2531 methyl deoxycholate 70.07 µM -0.105077252765446 0.473155747979317 no 1790 0.458157254514727 2616 16667744 Haematoxylin.
SGTC_606 k015-0008 38.6 µM -0.105988863661974 0.472752391827933 no 1791 0.457795593962869 2659 1970475
SGTC_3245 9134821 49.47 µM -0.106368536800695 0.472584407871849 no 1792 0.457644977710956 2590 17014901
SGTC_2415 st077333 57.7 µM -0.108314311551133 0.471723589427362 no 1793 0.456873185215054 2588 2766255
SGTC_226 1,3-diallylurea 8.28947 mM -0.109074734612566 0.471387210930273 no 1794 0.45657160708166 2693 74537 YKL182W FAS1
SGTC_1827 berberine 7.24 µM -0.109078304920264 0.47138563162747 no 1795 0.456570191183028 2608 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2243 6634756 200 µM -0.110524281730226 0.470746050291256 no 1796 0.455996796899517 2872 885676
SGTC_2750 bromebric acid 70.15 µM -0.111130375095356 0.470477986730854 no 1797 0.455756481038557 2698 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_881 0833-0569 170 µM -0.111973196872119 0.470105244960548 no 1798 0.455422329346646 2612 5418700
SGTC_3028 9087778 49.47 µM -0.112342030307767 0.469942134913628 no 1799 0.455276108672948 2626 17217395
SGTC_1510 1123-0200 71.5 µM -0.113590321182752 0.469390137988865 no 1800 0.454781280132841 2800 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_960 1222-0186 7.7 µM -0.113636897078686 0.469369543158801 no 1801 0.454762818575412 2722 3126296
SGTC_1043 0916-0009 19.3 µM -0.113698551077835 0.469342281251351 no 1802 0.454738380573234 2592 3101130
SGTC_67 0335-0847 266 µM -0.11453038582395 0.468974478145945 no 1803 0.454408680233332 2986 4552207 YOR254C SEC63
SGTC_2752 diclazuril 33.15 µM -0.115661320297484 0.468474467972667 no 1804 0.45396048119121 2703 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3259 9138485 49.47 µM -0.118546990903124 0.467198878795718 no 1805 0.452817132103744 2681 17646153
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.119401940829445 0.46682101863707 no 1806 0.45247846186851 2659 688788
SGTC_743 1275-0778 158 µM -0.120555236243376 0.466311346876908 no 1807 0.45202166322807 2724 2849257 YMR203W TOM40
SGTC_3012 9080433 71.4286 µM -0.120667857987994 0.466261579295153 no 1808 0.451977059265385 2618 17688859
SGTC_266 formosanin C 406 nM -0.12078913857583 0.466207985958037 no 1809 0.45192902663643 2635 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_168 3970-0862 530.542 µM -0.120956550608107 0.466134008353501 no 1810 0.45186272501345 2690 3135186
SGTC_2041 5107442 45.335 µM -0.121066506546386 0.466085420625059 no 1811 0.451819178950522 2671 793005
SGTC_1350 1495-0454 146 µM -0.121728147161268 0.465793063170368 no 1812 0.45155716039495 2748 1069057
SGTC_1463 k081-0032 34.1 µM -0.122167211647762 0.465599065042894 no 1813 0.451383296611833 2663 977755
SGTC_479 n-linoleoylglycine 10 µM -0.122192442310327 0.465587917267159 no 1814 0.451373305883112 2626 6433346 An anti-infammatory.
SGTC_1005 4092-0690 4.4 µM -0.122653622614905 0.465384156690963 no 1815 0.451190695132546 2671 1529343
SGTC_1446 4239-0190 62 µM -0.122771514786034 0.465332070542114 no 1816 0.451144015745252 2647 1340085
SGTC_107 0358-0022 2.6945 µM -0.123512749197524 0.46500459809697 no 1817 0.450850539596234 2705 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_43 0570-0105 72.5 µM -0.123765128805632 0.464893103857951 no 1818 0.450750621330811 2641 1114046 YDL195W SEC31
SGTC_2464 5717415 7.67 µM -0.123808935428749 0.464873751599829 no 1819 0.450733278401849 2633 5285744
SGTC_387 norethindrone acetate 66.7 µM -0.12396895565157 0.464803060880234 no 1820 0.450669927608484 2679 541197
SGTC_760 0568-0725 82.9 µM -0.124074665532936 0.464756362969368 no 1821 0.450628078556871 2775 3916171
SGTC_2802 7925815 54.55 µM -0.124672316739266 0.464492356470882 no 1822 0.450391487208056 2639 1262923
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.125610260422925 0.464078060702703 no 1823 0.450020220323963 2624 4174840
SGTC_68 0986-0284 82.829 µM -0.125920164761155 0.463941182498007 no 1824 0.44989756027713 2870 423278 YIL048W NEO1
SGTC_799 1310-0557 151 µM -0.128162352340451 0.462950983715492 no 1825 0.449010246397556 2760 5354492
SGTC_1626 st003712 1.76 µM -0.129169823911751 0.462506136732811 no 1826 0.448611636586829 2765 24207035
SGTC_2540 epiandrosterone 100 µM -0.129181135865901 0.462501142228081 no 1827 0.448607161264534 2656 441302 A steroid.
SGTC_162 k030-0015 37.8 µM -0.130659823852074 0.461848316466479 no 1828 0.448022207862484 2706 1809920 YMR134W ERG29
SGTC_511 blebbistatin 171 µM -0.132797914002634 0.460904553526355 no 1829 0.447176602066597 2786 3476986 A myosin inhibitor.
SGTC_2416 tofa 880 nM -0.133381494053473 0.4606469965994 no 1830 0.446945840118527 2680 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3340 9146634 11.102 µM -0.133984982680142 0.460380670595524 no 1831 0.44670722472049 2701 4907387
SGTC_898 1000-0849 28.3 µM -0.134752022460147 0.460042193378929 no 1832 0.446403970137713 2617 6751807
SGTC_3165 9101544 49.47 µM -0.135058796705662 0.459906828970988 no 1833 0.446282693542391 2742 5002184
SGTC_1621 st003705 32.4 µM -0.135194260278087 0.459847057027646 no 1834 0.44622914253319 2789 24207032
SGTC_1394 3474-0001 65.7 µM -0.135685352016214 0.459630375339195 no 1835 0.446035014008892 2711 5017666 YIL048W NEO1
SGTC_1407 3909-7909 12.3 µM -0.136696596286282 0.459184227465887 no 1836 0.445635310023579 2657 4411780
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.13754346564432 0.458810639197387 no 1837 0.445300619288027 2628 756377
SGTC_491 tetrandrine 80.3 µM -0.138003949596122 0.45860751637893 no 1838 0.445118648045509 2740 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2818 7996756 12.99 µM -0.138769313738767 0.458269932627198 no 1839 0.444816221707539 2647 2241621
SGTC_235 0330-0087 5 mM -0.138953074713835 0.458188884543598 no 1840 0.44474361508666 2661 46494818 YHR062C RPP1
SGTC_400 oxethazaine 37.5 µM -0.140318314564963 0.457586797894771 no 1841 0.444204247275134 2716 4621 A local anesthetic.
SGTC_626 0214-0009 33 µM -0.140343522320621 0.457575681892271 no 1842 0.44419428936927 2752 3437874
SGTC_2808 7946468 45.46 µM -0.140648717756611 0.45744110082001 no 1843 0.44407372977026 2725 2970879
SGTC_233 rapamycin 362 pM -0.141173106750327 0.457209874058158 no 1844 0.443866595490737 2697 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3172 9105863 49.47 µM -0.141176166848742 0.457208524765165 no 1845 0.443865386793151 2687 2348785
SGTC_254 nsc-64875 3.808 µM -0.142077813445597 0.45681098216256 no 1846 0.443509271343438 2809 56993
SGTC_2558 carylophyllene oxide 100 µM -0.14273396115535 0.456521708968633 no 1847 0.443250147097232 2642 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1201 1889-3372 45.9 µM -0.143488582975461 0.456189050386761 no 1848 0.442952163706635 2695 5392199
SGTC_81 0411-0046 9.971 µM -0.144152791813576 0.455896273797807 no 1849 0.442689909085299 2644 12925265
SGTC_803 4488-1585 147 µM -0.144274814879003 0.455842489854431 no 1850 0.442641732518185 2780 747204
SGTC_1985 st071382 65.5 µM -0.144709068473999 0.455651091048762 no 1851 0.442470289461202 2666 6123237
SGTC_1427 4048-4900 550 nM -0.144876602185747 0.455577252722514 no 1852 0.442404150131151 2782 24132586
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.145173574287938 0.455446369864611 no 1853 0.442286914772401 3016 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3103 9120822 49.47 µM -0.145395871480841 0.455348401226609 no 1854 0.442199162054701 2876 17141819
SGTC_2887 9044784 58.44 µM -0.146243657731943 0.454974798162615 no 1855 0.441864521067473 2678 6465546
SGTC_2395 5646831 180.19 µM -0.146786894729154 0.454735424998643 no 1856 0.441650114561161 2793 6808628
SGTC_2777 climbazole 1.536 µM -0.147823458036044 0.454278717102685 no 1857 0.441241047943121 2679 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_268 camptothecin 39.6153 µM -0.148050083343331 0.454178874438064 no 1858 0.441151621462186 2660 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2056 5235370 200 µM -0.148457820564029 0.453999247908932 no 1859 0.440990735670818 2719 5511916
SGTC_2991 9074669 71.4286 µM -0.148673968407172 0.453904028905261 no 1860 0.440905451558132 2812 17333109
SGTC_131 0141-0277 33.849 µM -0.149645288483039 0.453476168776808 no 1861 0.440522237711277 2822 1547771
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.149990873703611 0.453323953749334 no 1862 0.440385907767515 2843 688798
SGTC_310 1273-0058 1.06 µM -0.151456502405763 0.452678485507527 no 1863 0.43980781049742 2747 2734232
SGTC_885 0865-0106 16.8 µM -0.151467463805205 0.452673658536035 no 1864 0.43980348740467 2672 2793380
SGTC_98 0074-0023 107.663 µM -0.152263566610444 0.452323104750077 no 1865 0.439489529723508 2744 3563821
SGTC_1176 0848-0131 83.3 µM -0.153317052163435 0.45185927290314 no 1866 0.439074126985733 2769 6769040
SGTC_2217 6934799 96.0675 µM -0.15366188200868 0.451707464404702 no 1867 0.438938170748774 2688 675606
SGTC_607 4491-0986 66.8 µM -0.153763799106225 0.451662597593137 no 1868 0.438897989221827 2793 698981 YDR232W HEM1
SGTC_2442 5158906 48.48 µM -0.154283693547885 0.45143373485988 no 1869 0.438693027017553 2814 1893835
SGTC_3140 9094243 49.47 µM -0.154523419351707 0.45132821059618 no 1870 0.438598523503319 2642 19291112
SGTC_3055 9094636 49.47 µM -0.155027167970379 0.4511064780482 no 1871 0.438399949641277 2836 25236176
SGTC_2869 9037858 32.47 µM -0.155396461219382 0.450943937745304 no 1872 0.43825438690822 2641 27187042
SGTC_1241 0364-0022 50.8 µM -0.155767917598146 0.450780453663123 no 1873 0.438107979970324 2756 4563895
SGTC_336 4111-0029 111 µM -0.156241232141284 0.450572152223661 no 1874 0.437921438624574 2734 3131175
SGTC_3286 9117135 37.221 µM -0.156909719106838 0.450277980375223 no 1875 0.437658000002603 2730 3438150
SGTC_1656 st012921 11 µM -0.156986662652301 0.450244122639249 no 1876 0.437627679714088 2794 6732821
SGTC_721 1187-1332 279 µM -0.157202031018806 0.450149355273885 no 1877 0.43754281384133 2655 25730
SGTC_307 1501-1223 22.3 µM -0.157280134963873 0.450114988323816 no 1878 0.437512037703127 2743 2830329
SGTC_2948 9070189 9.45 µM -0.157395713797388 0.450064132526692 no 1879 0.437466495624963 2803 6473636 YDL196W YDL196W
SGTC_3080 9117754 49.47 µM -0.158400490073704 0.449622055952654 no 1880 0.437070613815576 2865 9550191
SGTC_737 1950-0117 57.9 µM -0.158889988229065 0.449406711550715 no 1881 0.436877774362253 2718 5393513
SGTC_2383 9036125 200 µM -0.160961191186672 0.448495695095254 no 1882 0.43606198347875 2688 79580
SGTC_950 1165-0508 94.1 µM -0.161340846863765 0.448328733248747 no 1883 0.435912476755332 2777 6148369
SGTC_763 3453-1109 128 µM -0.162648232876229 0.447753852002393 no 1884 0.435397704132374 2680 1560353
SGTC_3126 9127922 49.47 µM -0.165268704392993 0.446601914910622 no 1885 0.434366245169857 2958 45595682
SGTC_1727 st034309 9.9045 µM -0.16564355476639 0.446437170459455 no 1886 0.434218734496077 3004 870305
SGTC_1515 3460-0031 42.1 µM -0.167025990766866 0.445829678408193 no 1887 0.433674799253291 2735 2876596
SGTC_3184 9108758 49.47 µM -0.167029181058249 0.445828276626034 no 1888 0.433673544141538 2675 902885
SGTC_3085 9117376 49.47 µM -0.167344762628409 0.445689616586383 no 1889 0.433549392602056 2775 16480349
SGTC_320 4092-0846 5.34 µM -0.168426104426045 0.44521454775939 no 1890 0.433124036538725 2803 1359356
SGTC_3290 9121031 71.43 µM -0.168891085914491 0.445010290326395 no 1891 0.43294115544288 2737 17014854
SGTC_1817 st052116 64.4 µM -0.169020115559102 0.444953612668244 no 1892 0.432890409551848 2842 4361398
SGTC_1096 rimcazole 32.2 µM -0.169231670521411 0.444860687312931 no 1893 0.432807209787544 2679 18528119 A dopamine reuptake inhibitor.
SGTC_2894 9048625 32.47 µM -0.169565669268049 0.444713984789333 no 1894 0.432675861727326 2830 4092861
SGTC_1215 3852-0577 11.2 µM -0.169607381081672 0.4446956642092 no 1895 0.432659458697538 2869 2884876
SGTC_2723 salbutamol 83.58 µM -0.170885095900066 0.444134526261049 no 1896 0.432157058015293 2808 9884233 β2-adrenoceptor agonist
SGTC_2403 6032726 181.2 µM -0.172255690151273 0.443532722667688 no 1897 0.431618258860567 2788 2881040
SGTC_2924 9010168 62.78 µM -0.172975117811199 0.443216886782709 no 1898 0.43133549294945 2799 2993929
SGTC_95 0471-0001 561.058 µM -0.173521857939404 0.442976886551661 no 1899 0.431120624164465 2727 4015405
SGTC_1987 st072290 61.9 µM -0.173619799486539 0.442933895766664 no 1900 0.431082135302761 2756 54697379
SGTC_3331 9141060 1.957 µM -0.173914161462829 0.442804691598082 no 1901 0.430966461497835 2725 4906567 YPR165W RHO1
SGTC_2168 5727979 200 µM -0.174145582690544 0.442703118253519 no 1902 0.430875525329546 2672 695210
SGTC_742 0kpi-0133 140 µM -0.17469267617264 0.442463007840579 no 1903 0.430660561425517 2879 2728852
SGTC_2667 digitoxin 100 µM -0.174735743999225 0.442444106969575 no 1904 0.430643640091824 2791 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_705 1124-0212 310 µM -0.175057394880122 0.442302950478983 no 1905 0.430517267604537 2749 9554485
SGTC_1262 0737-0114 49.6 µM -0.175607332063914 0.4420616275211 no 1906 0.43030122085957 2776 765919
SGTC_1247 0448-0043 5.84 µM -0.175669124447276 0.442034513183075 no 1907 0.430276946583703 2831 3089013 YGL099W LSG1
SGTC_15 0266-0086 27.098 µM -0.176384223475555 0.441720749367903 no 1908 0.429996049097393 2763 1712902 YIL048W NEO1
SGTC_1672 st016598 6.51 µM -0.177171130876444 0.44137552047662 no 1909 0.429686985569132 2772 4665860 YNL267W PIK1
SGTC_47 0149-0135 24.25 µM -0.178232378124994 0.44091000487655 no 1910 0.429270241366953 2690 5239155
SGTC_1831 st055328 12 µM -0.180277946833862 0.440012948018469 no 1911 0.428467183946766 2859 1103068
SGTC_972 1319-0219 195 µM -0.181733611159711 0.439374773065876 no 1912 0.427895893643704 2799 23903702
SGTC_1236 0330-0013 258 µM -0.182935975489666 0.438847765589396 no 1913 0.427424127411367 2781 4617066
SGTC_809 3998-0021 90 µM -0.183059733504205 0.438793527436592 no 1914 0.427375574919359 2812 715485
SGTC_2297 7971671 152.32 µM -0.183116596207751 0.438768607189351 no 1915 0.427353267028164 2881 909016
SGTC_1009 4106-0057 9.87 µM -0.183793496138233 0.438471972472311 no 1916 0.427087729276825 2723 2928005
SGTC_624 k048-0052 28 µM -0.184004560614544 0.438379485726431 no 1917 0.427004938579791 2782 6835531
SGTC_1703 st026983 48.3 µM -0.185189198015285 0.437860449792758 no 1918 0.42654032064502 2848 1104023
SGTC_2516 gossypol 71.55 µM -0.18527248824926 0.437823961098338 no 1919 0.426507657821459 2878 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2598 perillyl alcohol 100 µM -0.185906455642567 0.43754624309499 no 1920 0.426259059793222 2891 10819 An apoptosis inducer.
SGTC_3110 9122132 49.47 µM -0.186246854922742 0.437397139265191 no 1921 0.426125590894361 2877 918317
SGTC_1963 st076565 50.3 µM -0.187062309345821 0.437039984996787 no 1922 0.425805889631654 2741 4914280
SGTC_788 1182-0090 188 µM -0.18707407121055 0.437034833887713 no 1923 0.425801278714859 2950 5715185
SGTC_2146 5545642 200 µM -0.188545123941312 0.43639067072782 no 1924 0.425224672984018 2750 825326
SGTC_1469 k284-2957 126 µM -0.189193601920287 0.436106760456933 no 1925 0.424970541019337 2770 23884841
SGTC_308 4092-1169 104 µM -0.189199671242271 0.43610410340115 no 1926 0.424968162660507 2766 2268590 YDL196W YDL196W
SGTC_2659 sanguinarine 24.21 µM -0.189254081737664 0.43608028345224 no 1927 0.424946841178134 2728 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_804 1595-0054 20.9 µM -0.189548850087044 0.43595124313433 no 1928 0.424831336065157 2759 761523 Stimulates phospholipase C.
SGTC_1741 st038134 10.228 µM -0.189873712296787 0.435809036568205 no 1929 0.424704046134915 2933 1272587
SGTC_3163 9099914 49.47 µM -0.189894745356917 0.435799829752816 no 1930 0.424695805075146 2813 16268368
SGTC_4 0960-0234 25.671 µM -0.190203304138702 0.435664768113971 no 1931 0.424574911028687 2808 6821112
SGTC_2188 6126565 140.678 µM -0.191027649926621 0.435303974218637 no 1932 0.424251965264341 2845 874518
SGTC_337 1315-0038 354 µM -0.194206072817701 0.433913371053851 no 1933 0.423007263989292 2760 1626437
SGTC_357 1325-0123 420 µM -0.194647272055515 0.433720404625498 no 1934 0.422834546516659 2874 1098503
SGTC_2083 5306046 65.942 µM -0.194677170736136 0.433707328470334 no 1935 0.422822842534614 2787 539837
SGTC_1960 st011366 51.8 µM -0.196006416904638 0.433126057639713 no 1936 0.422302571728135 2735 3972846
SGTC_1768 st044301 37.178 µM -0.196904868713478 0.432733252269092 no 1937 0.421950991793897 2799 3931349
SGTC_1286 0929-0070 131 µM -0.197216318221594 0.432597101261026 no 1938 0.421829130646981 2868 1420408
SGTC_3178 9107506 49.47 µM -0.197771401167911 0.432354465076896 no 1939 0.421611961376546 2889 8897194
SGTC_2037 5169046 200 µM -0.198339558663481 0.432106140202805 no 1940 0.421389701540846 2865 5718022
SGTC_810 3825-7150 143 µM -0.199112513606471 0.431768347491379 no 1941 0.421087366387126 2954 22330411 YGL099W LSG1
SGTC_777 1315-0167 517 µM -0.199420817968795 0.431633627840168 no 1942 0.420966788568123 2852 4221767
SGTC_1493 4348-0038 111 µM -0.199989708873803 0.431385060660986 no 1943 0.42074431483475 2789 800424
SGTC_102 gallobenzophenone 83.616 µM -0.200404727586389 0.431203742447032 no 1944 0.420582031204789 2923 70837
SGTC_2504 purpurogallin 52.29 µM -0.200408591655871 0.431202054335364 no 1945 0.420580520311663 2753 5281571 An antioxidant.
SGTC_845 0330-0138 4.51 µM -0.200873614526661 0.430998907097546 no 1946 0.420398699869076 2848 9039800
SGTC_2505 galangin 7.89 µM -0.201267486724186 0.430826856613162 no 1947 0.420244712086962 2730 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_229 benomyl 22.8748 µM -0.201352128080989 0.430789885453478 no 1948 0.420211622400536 2837 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1256 0570-0116 285 µM -0.201446702073921 0.430748576457546 no 1949 0.420174650317092 2790 410638
SGTC_1980 st071811 45.7 µM -0.203529257618246 0.429839129378831 no 1950 0.419360689972471 2918 4974850
SGTC_1814 st052110 31.539 µM -0.204440818313545 0.429441169793587 no 1951 0.419004517649856 2877 674163
SGTC_1451 4152-0210 104 µM -0.205064268048659 0.429169031923278 no 1952 0.418760956559888 2930 659563
SGTC_1606 st000094 49.2 µM -0.205323930255755 0.429055698434003 no 1953 0.418659524345404 2771 1242210
SGTC_1304 1165-0502 251 µM -0.207395048426915 0.428151937772915 no 1954 0.417850674660694 2812 767425
SGTC_438 sphingosine 6.67 µM -0.209226313368669 0.427353153989308 no 1955 0.417135785939926 2766 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1246 0422-0085 105 µM -0.210791450611907 0.426670688911269 no 1956 0.416525005042327 2891 264295
SGTC_936 3005-4620 401 µM -0.210796317144295 0.426668567241519 no 1957 0.416523106234777 2983 777207
SGTC_720 r052-1644 49.9 µM -0.211501643694715 0.426361087389956 no 1958 0.416247924869968 2893 1422863 YOR257W CDC31
SGTC_3155 9099265 49.47 µM -0.214090261047603 0.425232991218227 no 1959 0.415238335146292 2887 25236499
SGTC_148 3253-0744 288.01 µM -0.214242012053803 0.425166878390998 no 1960 0.415179167850138 2769 6893655
SGTC_1787 fluconazole 80 µM -0.215573157752715 0.424587033220753 no 1961 0.414660240423924 2822 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2156 5649887 115 µM -0.216865664644756 0.424024175165541 no 1962 0.414156518225626 2893 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2 0422-0095 29 µM -0.217175547828789 0.423889250903253 no 1963 0.414035769964481 2769 6790840
SGTC_2311 7694451 200 µM -0.217461941895402 0.423764561820313 no 1964 0.413924181635791 2875 2163142
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.217720134621167 0.423652157464111 no 1965 0.41382358741191 2893 16725076
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.217766971003198 0.423631767882835 no 1966 0.413805340139095 2786 688664
SGTC_1795 st049545 62.3 µM -0.218565949792948 0.423283974883932 no 1967 0.413494089799558 2768 5291882
SGTC_2664 lyso-paf C-16 73.48 µM -0.2193785012795 0.4229303350329 no 1968 0.41317760782008 2795 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_174 3553-0389 74.3 µM -0.221025269565567 0.422213816853769 no 1969 0.412536378622264 2943 738071
SGTC_2836 9010338 19.48 µM -0.22106835786087 0.422195072338053 no 1970 0.412519603750987 2811 2994051
SGTC_588 3970-1144 52.9 µM -0.222273854756164 0.421670721796639 no 1971 0.412050351960216 2940 1888707
SGTC_1480 1070-0044 41.2 µM -0.222598969640397 0.421529331508374 no 1972 0.411923819219611 2887 3124987
SGTC_487 nimodipine 119 µM -0.223060220486943 0.421328753962844 no 1973 0.411744318902451 2882 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2957 9076800 11.52 µM -0.223869317389168 0.420976962928785 no 1974 0.411429495492109 2858 16459615
SGTC_585 0kpi-0023 191 µM -0.224373490718034 0.42075778292991 no 1975 0.411233348101351 2941 64601
SGTC_1030 k029-0042 36.7 µM -0.22521207287068 0.420393279334308 no 1976 0.410907148948294 2864 6080581
SGTC_597 k018-0003 82.8 µM -0.226061814668623 0.420023994638301 no 1977 0.410576671652876 2927 6786234
SGTC_237 nikkomycin 200 µM -0.226442893920834 0.419858406311588 no 1978 0.410428484834853 2957 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_195 4234-0266 16.654 µM -0.227214315698145 0.419523247995451 no 1979 0.41012854823708 2837 2303354
SGTC_2191 5911152 200 µM -0.227502731455147 0.41939795546803 no 1980 0.410016422762358 2852 2875902
SGTC_2133 5320837 200 µM -0.228235765006774 0.419079550497467 no 1981 0.40973147931727 2961 2841355
SGTC_2537 larixol 68.93 µM -0.229831895680264 0.418386428927633 no 1982 0.409111199453872 2757 6708759
SGTC_2148 5546263 113.568 µM -0.232204104270575 0.417356763294831 no 1983 0.408189745062939 2801 792097
SGTC_1756 st041558 35.5 µM -0.232377345573597 0.417281589397134 no 1984 0.408122471494781 3001 3955792
SGTC_552 k242-0005 476 µM -0.233543224321767 0.416775763124197 no 1985 0.407669804593388 2929 4088318
SGTC_2245 6637752 200 µM -0.233554736604455 0.416770769109275 no 1986 0.407665335420171 2981 681890
SGTC_566 0958-0068 16.5 µM -0.234007233279682 0.416574487222052 no 1987 0.407489681604817 2990 6815365
SGTC_3145 9085516 49.47 µM -0.235127088801814 0.416088811072143 no 1988 0.407055047082757 2912 25236195
SGTC_2773 thioridazine 9.09 µM -0.235782258597374 0.415804726320578 no 1989 0.406800817829932 2794 5452 An antipsychotic.
SGTC_2470 5664817 21.68 µM -0.236786110100592 0.415369536906898 no 1990 0.406411363851271 2808 2859561
SGTC_2724 maprotiline 69.64 µM -0.237349353944924 0.415125405022146 no 1991 0.406192888423401 2864 4011 A tricyclic antidepressant.
SGTC_1665 st014639 11.4 µM -0.238029075697613 0.41483083070287 no 1992 0.405929271528264 2855 981133 YIL048W NEO1
SGTC_1285 0929-0069 65.5 µM -0.238629006971831 0.414570875346548 no 1993 0.405696635250934 2856 1206237
SGTC_1618 st003135 44.5 µM -0.23869351250231 0.414542926773562 no 1994 0.405671623823141 2757 1270615
SGTC_1811 st050069 61.5 µM -0.240115860670406 0.413926770398764 no 1995 0.405120219405799 2833 3877702
SGTC_1591 genipin 88.4 µM -0.240622247416193 0.413707456441516 no 1996 0.404923952889475 2971 442424 A DNA cross-linking agent.
SGTC_831 k061-1017 217 µM -0.240655355686514 0.413693118326365 no 1997 0.404911121543774 2880 1240153
SGTC_1342 1486-1464 234 µM -0.243915001633802 0.412282037977943 no 1998 0.403648325202332 2828 3253938
SGTC_2502 avocadyne acetate 18.59 µM -0.243991370241893 0.412248991999799 no 1999 0.403618751763817 2767 3952079
SGTC_2568 diosmetin 100 µM -0.244062820866446 0.412218074678982 no 2000 0.403591083293744 2972 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2441 5730946 39.09 µM -0.244572778406286 0.411997427345748 no 2001 0.403393621852706 2964 1774275
SGTC_2907 7721985 69.9 µM -0.245454078629069 0.411616173874946 no 2002 0.403052430323376 2893 3267881
SGTC_1341 1486-1360 280 µM -0.246566201467354 0.411135184867997 no 2003 0.40262198218052 2821 3976547
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.246983142639549 0.410954893739176 no 2004 0.402460635115436 2994 5282362
SGTC_609 0986-0026 86.3 µM -0.247130799184359 0.410891049515183 no 2005 0.402403499261968 2862 2848610
SGTC_2824 7998404 51.95 µM -0.249420403385599 0.409901365994741 no 2006 0.401517802073493 2827 837851
SGTC_1401 3807-4679 7.6 µM -0.250908897403941 0.409258270401876 no 2007 0.400942272642933 2827 3291456
SGTC_924 2046-0044 21.3 µM -0.251510876220428 0.408998258023149 no 2008 0.400709577195698 2815 3623589
SGTC_875 0709-0210 25.7 µM -0.253886353401734 0.407972611255576 no 2009 0.399791678926642 2857 6251364
SGTC_490 phenamil 164 µM -0.253921541936659 0.407957422814966 no 2010 0.399778086018771 2943 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2138 5575593 77.673 µM -0.254416297372817 0.407743885993372 no 2011 0.399586980809647 2861 762213
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.254573947918496 0.407675849652639 no 2012 0.399526091450706 2946 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3225 9130819 49.47 µM -0.255072745616743 0.407460604745257 no 2013 0.399333456955284 2988 4547121
SGTC_1527 coumarin 137 µM -0.256014351427119 0.407054352170068 no 2014 0.39896987784567 3059 323 A hepatotoxic, DNA x-linker.
SGTC_1966 st070145 16.1 µM -0.256707544718893 0.406755340185139 no 2015 0.398702273421511 2808 3748532
SGTC_1029 k015-0030 64.7 µM -0.257513612270784 0.406407707746885 no 2016 0.398391154237531 2977 2208316
SGTC_1555 citronellol 128 µM -0.259866396809303 0.405393446060454 no 2017 0.397483416221788 2943 8842 A terpine precursor.
SGTC_1706 st031321 9.9705 µM -0.260550423053315 0.405098688080705 no 2018 0.39721961298089 2968 6103185
SGTC_2612 dictamnine 15.46 µM -0.261408558499258 0.404728979767106 no 2019 0.396888728855302 2959 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3169 9102970 49.47 µM -0.263380819946338 0.403879598188979 no 2020 0.396128536169237 2874 17027839
SGTC_2911 7942208 15.64 µM -0.263889356280094 0.403660663312626 no 2021 0.39593258874243 2954 1243384
SGTC_2572 astragaloside iv 100 µM -0.264388767479033 0.403445686360714 no 2022 0.395740182970483 3048 45006101 An anti-inflammatory agent.
SGTC_1902 st060212 70.5 µM -0.264720661590332 0.403302835082208 no 2023 0.395612329756489 2886 688944
SGTC_391 gliotoxin 8.33 µM -0.269594339022198 0.401206640166851 no 2024 0.393736177974854 3049 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2225 6654152 15.4 µM -0.270628642755068 0.400762143902359 no 2025 0.393338331943646 2936 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_556 4058-0063 51.5 µM -0.273252948406416 0.399634915499776 no 2026 0.392329390555946 2939 6615692
SGTC_2564 betulinic acid 100 µM -0.273582253105201 0.399493526791464 no 2027 0.392202836905974 3186 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_828 2074-0507 139 µM -0.274110516410816 0.399266741694347 no 2028 0.391999846162552 3032 X828
SGTC_1711 st032263 62.8 µM -0.274387831551885 0.399147703033566 no 2029 0.391893296657639 2932 3958979
SGTC_1368 1852-0141 284 µM -0.275078156586886 0.398851418933358 no 2030 0.391628096489766 3001 2838987
SGTC_3296 9122258 64.045 µM -0.275845487827048 0.398522152543757 no 2031 0.391333372170298 2984 4730474
SGTC_2656 pseudo-anisatin 100 µM -0.276321905812278 0.39831775508591 no 2032 0.391150416123351 2914 6708809 A neurotoxin.
SGTC_2832 7992762 51.95 µM -0.279015821160516 0.397162511810356 no 2033 0.390116341602428 2862 2985177
SGTC_2874 9043904 71.43 µM -0.279647030212704 0.396891957738546 no 2034 0.389874160563924 2964 4463428
SGTC_929 2805-0021 398 µM -0.280273833698455 0.396623341119278 no 2035 0.389633712142736 2976 3098024
SGTC_823 0417-1665 178 µM -0.280893249311812 0.3963579387601 no 2036 0.389396139280537 3001 3429856
SGTC_495 decylubiquinone 155 µM -0.281465210789827 0.396112911817352 no 2037 0.389176803847106 2969 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_610 4215-0184 155 µM -0.28154320145391 0.396079503978737 no 2038 0.389146898769493 2948 5605015
SGTC_2674 ligustilide 100 µM -0.282100549131599 0.395840782488602 no 2039 0.388933206088596 2988 5319022 A signalling regulator.
SGTC_1289 0976-0073 69.1 µM -0.282483517341039 0.395676773327751 no 2040 0.388786391711675 3012 3391136
SGTC_542 3381-0244 89.3 µM -0.282762302345308 0.395557393063023 no 2041 0.388679526909979 3075 1112843
SGTC_230 MPP+ 141.667 µM -0.28322811771947 0.395357945227569 no 2042 0.388500987800693 2946 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2088 5278280 127.392 µM -0.284098473817773 0.394985358961797 no 2043 0.388167458259278 3000 791502
SGTC_663 1486-0733 13.9 µM -0.284168424515175 0.394955418291171 no 2044 0.388140655998825 2905 722445 YPR165W RHO1
SGTC_1437 4092-1038 11.6 µM -0.284247857229337 0.394921419829274 no 2045 0.388110221261433 2921 3977136
SGTC_245 methotrexate 289.6 µM -0.284661780880474 0.394744266892884 no 2046 0.387951637054309 2991 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1122 capsaicin 818.572 nM -0.284714869870521 0.394721547198008 no 2047 0.387931298723793 3040 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_169 k015-0017 16.025 µM -0.284880476289234 0.394650677415931 no 2048 0.38786785707226 3128 1840002
SGTC_3034 9090421 49.47 µM -0.287119638417935 0.393692791216821 no 2049 0.387010357839964 2908 17173761
SGTC_857 0438-0306 1.35 µM -0.287132277874804 0.393687386031052 no 2050 0.387005519052199 3012 4686136
SGTC_1949 st076024 69.1 µM -0.287787162801639 0.393407356580803 no 2051 0.386754832229696 2848 2921930
SGTC_201 4262-0159 12.803 µM -0.28810792519942 0.393270218363811 no 2052 0.386632063145821 2981 1341029
SGTC_1796 st049173 110.4 µM -0.288435295349336 0.393130268733481 no 2053 0.386506776699064 3016 94134
SGTC_519 k048-0011 62.8 µM -0.288650611683755 0.393038229257344 no 2054 0.386424380342731 3030 6836379
SGTC_3087 9117406 49.47 µM -0.289308890865758 0.392756877253414 no 2055 0.386172504587276 3037 42546093
SGTC_1715 st032160 10.2275 µM -0.289460632335791 0.392692030087159 no 2056 0.386114450918089 3028 5289825
SGTC_1233 0325-0408 14.2 µM -0.289724503262006 0.392579271160451 no 2057 0.386013504526033 3014 12874
SGTC_918 glabranin 770.725 nM -0.290779328038799 0.392128607181208 no 2058 0.385610048185143 2963 124049 Also referred to as licorice root.
SGTC_2233 sulbentine 40.3845 µM -0.291668001621151 0.391749041985636 no 2059 0.385270238463293 2955 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1499 4480-0877 67.3 µM -0.292134404957315 0.391549875649238 no 2060 0.385091931052026 2923 2861909
SGTC_2885 9057732 51.95 µM -0.29263011878369 0.391338224133575 no 2061 0.384902444783334 3080 6471414
SGTC_653 0203-0016 55.2 µM -0.292794081996999 0.391268224967396 no 2062 0.38483977600487 2968 295302
SGTC_175 3793-3120 23.7 µM -0.293360306966268 0.391026519326467 no 2063 0.384623380926164 2928 5322297
SGTC_1363 1636-0063 10.4 µM -0.294049653616477 0.390732313290608 no 2064 0.384359980763665 2932 6072185
SGTC_1847 st056231 15 µM -0.29589145222708 0.389946559840894 no 2065 0.383656489538669 2922 5393180
SGTC_1687 st020778 55.3625 µM -0.296119035374877 0.389849498798768 no 2066 0.383569588709916 2963 4259299
SGTC_51 1013-0126 23.419 µM -0.296821183553735 0.389550085690736 no 2067 0.383301515893165 3205 1627850
SGTC_2180 6301957 200 µM -0.297947363761137 0.389069991926995 no 2068 0.382871668797701 3054 845462
SGTC_2198 6589944 200 µM -0.298015410223891 0.389040988947257 no 2069 0.382845701037903 2959 5290268
SGTC_3036 9090181 49.47 µM -0.298850770261805 0.388684989567031 no 2070 0.382526955499031 2905 25236586
SGTC_1650 st011916 45.8 µM -0.298870513266627 0.388676576962073 no 2071 0.382519423188278 3061 242528
SGTC_2282 7944268 200 µM -0.29902597238713 0.388610336784308 no 2072 0.38246011429615 3125 2970414
SGTC_2292 7671323 168.05 µM -0.300229130219423 0.388097788284218 no 2073 0.382001193341368 3097 937504
SGTC_1829 berberine 14.4 µM -0.301689553054785 0.387475906069648 no 2074 0.381444366447094 3114 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2108 5365811 200 µM -0.302549620532077 0.38710980413777 no 2075 0.381116556449615 3041 780283
SGTC_635 k038-0028 24.7 µM -0.302667609912636 0.387059587832756 no 2076 0.381071592092832 2978 4035102
SGTC_2306 7482397 179.52 µM -0.302972644172068 0.386929773950358 no 2077 0.380955354588984 3104 891448
SGTC_921 1561-0023 372 µM -0.304130417859857 0.386437173702055 no 2078 0.380514266830075 2908 24050882
SGTC_1724 st037281 8.293 µM -0.304267214838901 0.386378982492965 no 2079 0.380462160266138 2921 574124 YDL195W SEC31
SGTC_1034 k072-0165 12.7 µM -0.305695163051473 0.38577170934047 no 2080 0.379918378226865 3101 5835461
SGTC_378 3970-0959 8.33 µM -0.305816622437765 0.385720068382953 no 2081 0.379872135783173 3066 6615653
SGTC_650 1328-0195 38 µM -0.306523596603617 0.385419524001219 no 2082 0.379603008213296 3042 2780821
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.307012222728871 0.385211842549475 no 2083 0.379417034412177 2959 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2030 5175110 200 µM -0.307409720352911 0.385042917851877 no 2084 0.379265765197636 3075 2831986
SGTC_3074 9116018 49.47 µM -0.307899630820609 0.384834750451714 no 2085 0.37907935335877 2916 17027303
SGTC_1574 spiramycin 23.7 µM -0.309004828026198 0.384365264126269 no 2086 0.378658927100839 2905 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_793 0488-0545 106 µM -0.309972151777487 0.383954485401541 no 2087 0.378291066851818 2942 292548
SGTC_2486 5283202 22.39 µM -0.310238341903621 0.383841469322427 no 2088 0.378189857653475 2988 1377751
SGTC_2487 5918373 44.05 µM -0.310488146511959 0.383735419011604 no 2089 0.378094886059282 3039 2876279
SGTC_1336 1486-0901 104 µM -0.310916041549522 0.383553783664705 no 2090 0.377932224537149 3012 5006114
SGTC_1028 k015-0029 4.8 µM -0.311393570179486 0.383351109776625 no 2091 0.37775072067768 2937 4588309
SGTC_2526 patulin 37.61 µM -0.311813588123677 0.383172871098526 no 2092 0.377591098361725 3103 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3171 9103192 49.47 µM -0.312434857995847 0.382909274568131 no 2093 0.377355031222865 3049 13018434
SGTC_1775 st081588 35.1725 µM -0.313591620541249 0.382418620173025 no 2094 0.376915612290604 2965 1426443 YGL099W LSG1
SGTC_1369 1866-0067 208 µM -0.314665210730049 0.3819634131284 no 2095 0.376507930591641 3111 3531355
SGTC_358 0075-0058 9.45 µM -0.314997297910434 0.381822639684553 no 2096 0.376381852734583 3022 1069125
SGTC_456 gingerol 170 µM -0.315694434729045 0.381527170696635 no 2097 0.376117225644216 3147 442793 A herb.
SGTC_1238 0333-0287 48.8 µM -0.317631606852028 0.380706497777018 no 2098 0.37538219799844 2975 7226
SGTC_3204 9114183 49.47 µM -0.317673514206817 0.380688749858895 no 2099 0.375366301939142 2901 17027248
SGTC_1472 k841-0093 193 µM -0.318908100707594 0.380166010758182 no 2100 0.374898100669652 3093 X1472
SGTC_2974 9094440 9.66 µM -0.319365629661274 0.37997234289523 no 2101 0.374724635390527 3150 25236134
SGTC_573 3702-0553 84.7 µM -0.319670381713589 0.379843360807444 no 2102 0.374609107256135 2980 1222756
SGTC_1351 1496-0003 46.5 µM -0.321000799586141 0.379280436572135 no 2103 0.374104892481701 3100 3891978
SGTC_559 1550-0661 158 µM -0.324511002892836 0.377796436006371 no 2104 0.372775596747375 3048 5830875
SGTC_463 ikarugamyin 104 µM -0.324688354023506 0.377721505313006 no 2105 0.372708474835476 3024 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_685 1278-0033 54.9 µM -0.324937215499008 0.377616369321832 no 2106 0.372614294989415 3126 3590572
SGTC_992 3909-8734 162 µM -0.325359353897609 0.377438050126849 no 2107 0.372454557148736 3017 4288319
SGTC_1001 4048-4355 44.4 µM -0.325471241006963 0.377390791286868 no 2108 0.372412222565645 2959 21824233
SGTC_3274 9138298 49.47 µM -0.326183054302599 0.377090178844715 no 2109 0.37214293079672 2940 17015756
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.32717655417975 0.376670729296084 no 2110 0.371767176478383 3142 5377381
SGTC_3180 9109287 49.47 µM -0.328761869800495 0.37600172038042 no 2111 0.371167842940518 3099 18891271
SGTC_1330 1469-0054 61.8 µM -0.329170296898506 0.375829422935166 no 2112 0.371013486333674 3127 7102664
SGTC_1041 0206-0046 107 µM -0.329260125139984 0.37579153166709 no 2113 0.370979540383537 3043 50494
SGTC_1554 st069299 38.7 µM -0.33137822516319 0.374898424444945 no 2114 0.37017940521675 3060 24207999
SGTC_3078 9116413 49.47 µM -0.33224483885126 0.374533205549936 no 2115 0.36985219419249 2912 17177322
SGTC_198 3454-2873 16.191 µM -0.332490095786761 0.374429866801071 no 2116 0.369759608578301 3012 710957
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.333364061131352 0.374061695816641 no 2117 0.369429744085557 3230 6710655
SGTC_2008 4012253 172 µM -0.333771126971301 0.373890252421202 no 2118 0.369276136265379 2962 603940
SGTC_1956 st077085 54 µM -0.335154129348873 0.373307961628439 no 2119 0.368754411164758 3012 24208685
SGTC_869 0564-0080 44.1 µM -0.336881753343477 0.372580979863975 no 2120 0.368103020437273 3031 6843321
SGTC_1450 4112-4260 37.6 µM -0.33725658186421 0.372423312353114 no 2121 0.367961743466818 3143 1633175
SGTC_1540 guanosine 70.6 µM -0.337949112361867 0.372132063243927 no 2122 0.367700768135997 2985 6802 Guanosine is a purine nucleoside
SGTC_2281 7943571 200 µM -0.338072150327998 0.372080326312807 no 2123 0.367654408514766 3221 1244024
SGTC_52 0329-0193 875 nM -0.338154796656192 0.372045575186774 no 2124 0.367623269189345 3200 3739292
SGTC_1725 st036284 20.55 µM -0.338546682751917 0.371880809122935 no 2125 0.367475626945662 3217 707914
SGTC_3336 9143619 71.43 µM -0.338618469429083 0.371850629404058 no 2126 0.367448583591438 3124 45595730
SGTC_1011 4112-3381 17.4 µM -0.338855881812641 0.371750824863659 no 2127 0.367359150687119 3153 2877139
SGTC_2334 9017922 200 µM -0.3394638054667 0.371495302348384 no 2128 0.367130179526721 3129 3163164
SGTC_955 1216-0110 33 µM -0.339900129689371 0.371311941412272 no 2129 0.366965869485686 2960 3619719
SGTC_1481 3346-2004 36 µM -0.339946157765829 0.371292600270839 no 2130 0.366948537751573 3071 2770522
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.342404620774897 0.370260019889982 no 2131 0.366023205779594 3022 689007
SGTC_1789 tunicamycin 25 nM -0.342616919567767 0.370170895876502 no 2132 0.36594333585778 3125 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2989 9073649 71.4286 µM -0.343244136578917 0.3699076280124 no 2133 0.365707401559339 3073 21367202
SGTC_1521 st012942 49.4 µM -0.344147844325716 0.369528413227011 no 2134 0.365367551679901 3205 24207259
SGTC_2662 daunorubicin 22.37 µM -0.344698653750989 0.369297344214027 no 2135 0.365160465166085 3012 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2980 9014342 25.29 µM -0.344863484711673 0.369228205466047 no 2136 0.365098501700847 3165 2996599
SGTC_2663 amphotericin b 100 µM -0.345231742182294 0.369073754257746 no 2137 0.364960078609258 3043 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3067 9117431 49.47 µM -0.346668629102612 0.368471310519853 no 2138 0.36442014033987 3043 17150885
SGTC_2094 5332512 191.667 µM -0.346819689495728 0.368407994160877 no 2139 0.364363392055688 3159 755774
SGTC_3109 9122853 49.47 µM -0.3470406793541 0.368315373584184 no 2140 0.364280378991164 3055 1234709
SGTC_728 3030-5151 22.5 µM -0.347725444144202 0.368028425725245 no 2141 0.364023193041966 3012 3125388
SGTC_453 enantio-paf c16 10 µM -0.348271369331355 0.367799710764004 no 2142 0.363818196736507 3135 13871343 A lipid and platelet activating factor
SGTC_368 fentichlor 4.58 µM -0.348718698979635 0.36761233726368 no 2143 0.36365025235602 3072 7329 A pesticide.
SGTC_2006 4011487 200 µM -0.349151868549609 0.367430925039458 no 2144 0.363487649166655 3185 45595294
SGTC_2182 6325192 200 µM -0.349395183405876 0.36732903729628 no 2145 0.363396324422052 3082 736248
SGTC_3037 9091026 49.47 µM -0.349696224416569 0.367202989737391 no 2146 0.363283343737884 3103 25236398 YIL048W NEO1
SGTC_1223 0764-0573 147 µM -0.350044366784087 0.367057238421188 no 2147 0.363152700746193 3021 1609797
SGTC_2196 6573537 42.6665 µM -0.351049384210248 0.36663659105359 no 2148 0.362775649905718 3138 2903087
SGTC_923 1900-2434 73.3 µM -0.351554153468354 0.366425381601142 no 2149 0.36258632655543 2976 5910570
SGTC_2074 5212007 75.395 µM -0.351601894777618 0.366405407406584 no 2150 0.362568422003853 3130 758611
SGTC_2646 retinol 96.75 µM -0.352965182178653 0.365835182831954 no 2151 0.362057271629358 3107 445354 A vitamin A analog and teratogen.
SGTC_3146 9095609 49.47 µM -0.353012882884426 0.365815236332884 no 2152 0.362039391195543 3071 17173999
SGTC_2988 9073640 71.4286 µM -0.353542600823161 0.36559375418343 no 2153 0.36184084862289 3227 9102229
SGTC_127 0180-0333 59.125 µM -0.355188409268622 0.364905905817283 no 2154 0.361224223714366 3061 771601
SGTC_2769 toremifene 3.73 µM -0.355942731407208 0.364590789884841 no 2155 0.360941726829091 3246 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_457 grayanotoxin iii 135 µM -0.356260926006541 0.364457892413154 no 2156 0.360822584317842 3116 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_838 0109-0203 71.4 µM -0.356283434591294 0.364448492072117 no 2157 0.3608141568756 3024 759422
SGTC_249 wiskostatin 11.211 µM -0.357311844312788 0.36401908066483 no 2158 0.360429181998084 3137 2775510 A n-wasp and actin depolymerizer.
SGTC_2956 9076196 2.52 µM -0.361553673640816 0.362249718493457 no 2159 0.358842794398781 3175 16423868
SGTC_2140 5586273 200 µM -0.361788327582429 0.362151924517941 no 2160 0.358755107688795 3086 854421
SGTC_129 0088-0017 176.636 µM -0.363689509982147 0.361359923253486 no 2161 0.35804493876566 3170 182446
SGTC_264 promethazine 12.5 mM -0.364140059622863 0.361172318602019 no 2162 0.357876712021774 3140 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1349 flufenamic acid 69 µM -0.364759516703972 0.360914436986216 no 2163 0.357645463485288 3025 3371 A non-steroidal anti-inflammatory.
SGTC_159 3970-0959 50 µM -0.365130334395099 0.360760094843886 no 2164 0.357507059116962 3159 6615653
SGTC_1102 cgs 12066b 26.1 µM -0.365601965112395 0.360563824957557 no 2165 0.357331054267604 3082 6438352 A 5-HT1B full agonist.
SGTC_2227 7312221 64.1025 µM -0.365780587184971 0.360489500679493 no 2166 0.357264403360374 3058 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1345 1488-0192 31.4 µM -0.365959749709131 0.360414956815308 no 2167 0.357197555163822 3194 658348
SGTC_2249 haloperidol 116.36 µM -0.365987085155376 0.36040358386642 no 2168 0.357187356288487 3029 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2153 5569715 200 µM -0.366893958876586 0.360026347917419 no 2169 0.356849058911389 3095 2054701
SGTC_2253 7938677 135.83 µM -0.366950162609625 0.36000297310306 no 2170 0.356828096545149 3225 2301972
SGTC_2062 5245942 200 µM -0.367824723087145 0.359639315850782 no 2171 0.35650196652998 3058 1376160
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.368133135870298 0.359511102810891 no 2172 0.356386982148279 3141 17037758
SGTC_1722 st034304 3.6505 µM -0.368334540129335 0.359427383777212 no 2173 0.356311900398812 3054 4036148 YLR033W RSC58
SGTC_2268 7933382 153.85 µM -0.369181764057483 0.359075286564819 no 2174 0.355996123738899 3054 935025 YOR257W CDC31
SGTC_1414 3917-0015 5.4 µM -0.369379759545 0.35899301899679 no 2175 0.355922341239721 3151 6618702
SGTC_2697 mebhydrolin 72.4 µM -0.370081529044465 0.358701484886687 no 2176 0.355660872149108 3227 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2323 6148992 148.28 µM -0.370440983709527 0.358552189521349 no 2177 0.355526970867124 3055 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1193 1488-0126 41.5 µM -0.370534736946839 0.35851325374438 no 2178 0.355492049564453 3069 1384710
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.370902873289508 0.358360380724506 no 2179 0.355354937495686 3108 676296 Flavone; oxidizing agent.
SGTC_3033 9090887 49.47 µM -0.371144251492423 0.358260157857635 no 2180 0.355265046548932 3062 19325384
SGTC_2386 9075165 157.42 µM -0.371189181530988 0.358241503492532 no 2181 0.355248315174215 3082 16452277
SGTC_3283 9109332 35.8195 µM -0.371670090039356 0.358041857763151 no 2182 0.355069248447371 3075 17027281
SGTC_1957 st077035 62.4 µM -0.372795869172197 0.357574650472162 no 2183 0.354650188759385 3181 705593
SGTC_3256 9138902 49.47 µM -0.373007260440926 0.357486945186184 no 2184 0.354571520131473 3069 17228773
SGTC_1506 4226-2149 212 µM -0.373059192897916 0.357465399794946 no 2185 0.354552194572038 3156 991114
SGTC_295 k015-0027 31 µM -0.37365730202121 0.357217293033986 no 2186 0.354329647980196 3125 3887424
SGTC_2942 9052777 62.25 µM -0.373721753650922 0.357190560902788 no 2187 0.354305669553209 3077 6469503
SGTC_1893 st059353 36.1 µM -0.373852293180041 0.357136420124458 no 2188 0.354257105715069 3119 3112488
SGTC_2349 9023730 187.07 µM -0.373855735089211 0.357134992644502 no 2189 0.354255825274307 3215 4126287
SGTC_205 1486-1330 71.903 µM -0.374883405895431 0.356708871179447 no 2190 0.353873590386716 3077 4118834
SGTC_2374 9071832 200 µM -0.375440252051172 0.356478050770876 no 2191 0.353666536877815 3129 17381698
SGTC_2460 5552655 174.22 µM -0.376174460320333 0.356173791669193 no 2192 0.35339360053354 3186 5401989
SGTC_1082 camptothecin 424.86 nM -0.377099649552859 0.355790519610852 no 2193 0.353049775813445 2887 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2737 bleomycin 30.5 nM -0.377811264441652 0.355495822716155 no 2194 0.352785402540748 3107 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2068 5226020 147 µM -0.378664704669121 0.35514250644123 no 2195 0.35246843322868 3109 1810509
SGTC_774 k060-0086 136 µM -0.379348718582338 0.354859420940022 no 2196 0.352214463097901 3263 5911235
SGTC_1127 asiatic acid 681.4 nM -0.380026036508447 0.354579185575639 no 2197 0.351963044072528 3051 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3175 9106517 49.47 µM -0.380310263299646 0.354461612239502 no 2198 0.351857558938547 3153 41468073
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.381261986861069 0.354068023010549 no 2199 0.351504428672684 3258 165506
SGTC_946 3434-1334 87.4 µM -0.381522836177157 0.353960174889995 no 2200 0.351407664744104 3196 4047976
SGTC_3306 9127676 59.7925 µM -0.38487671172222 0.352574561888839 no 2201 0.350164380341369 3146 41905287
SGTC_1093 fluphenazine 7.97 µM -0.385882555654354 0.352159389671269 no 2202 0.349791825258093 3096 6602611 An atypical antipsychotic.
SGTC_2784 7567673 72.73 µM -0.386078274793723 0.352078625081317 no 2203 0.34971934953194 3153 3471247
SGTC_1123 mangostin 811.285 nM -0.38695486308521 0.351716977962199 no 2204 0.349394811950864 3128 5281650 An antioxidant.
SGTC_1622 st003707 19.4 µM -0.387473637480284 0.351503014462553 no 2205 0.349202798943477 3203 10140899
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.387696448144718 0.35141113278808 no 2206 0.349120342289021 3066 803109
SGTC_690 glyoxal 20.3 µM -0.388351563526235 0.351141029519806 no 2207 0.348877941741689 3142 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2301 7769476 200 µM -0.390653864568833 0.350192390788665 no 2208 0.34802655247009 3148 977820
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.39072766992774 0.350161995492245 no 2209 0.347999271942525 3070 16486 A toxic proline analog.
SGTC_1283 0922-0125 16.4 µM -0.392741594266102 0.34933297107521 no 2210 0.347255173145684 3180 3360884
SGTC_160 3453-0671 289.699 µM -0.393554394205148 0.348998588241335 no 2211 0.346955028721528 3093 5322268
SGTC_1252 0493-0875 34.8 µM -0.394216640142964 0.348726229403841 no 2212 0.346710550667757 3080 3960963
SGTC_2048 5246248 200 µM -0.396690212974091 0.347709624724333 no 2213 0.345797959107681 3230 677046
SGTC_7 0192-1582 4.227 µM -0.397608304629182 0.347332579575285 no 2214 0.345459468989786 3133 252616
SGTC_1253 0550-0034 176 µM -0.397884115754861 0.347219337964766 no 2215 0.345357804635345 3208 5969915
SGTC_2304 7443016 91.4 µM -0.400532000941395 0.346132873411793 no 2216 0.34438235918204 3077 939854
SGTC_2040 5100729 123 µM -0.401020115497476 0.345932730993219 no 2217 0.344202657014014 3100 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1403 3909-7815 62.9 µM -0.403157480308467 0.345056851236757 no 2218 0.34341618860196 3082 6615483
SGTC_818 4072-2707 53.5 µM -0.403523515043048 0.34490693537722 no 2219 0.343281569689533 3051 882871
SGTC_2772 vinpocetine 57.06 µM -0.403526000082028 0.344905917669678 no 2220 0.343280655818942 3296 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_3070 9117005 49.47 µM -0.403721754026784 0.344825753332137 no 2221 0.343208670381913 3205 8779016
SGTC_2694 st077685 81.9 µM -0.403744119804754 0.344816594635537 no 2222 0.343200446080602 3055 2838096
SGTC_2489 cantharidin 73.42 µM -0.404245527009083 0.344611294271594 no 2223 0.34301608907909 3138 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_679 0422-0091 41.4 µM -0.404685305440967 0.344431265373458 no 2224 0.342854422451627 3105 627384 YHR062C RPP1
SGTC_2132 5317594 122.667 µM -0.40513712686236 0.344246343221968 no 2225 0.342688358671939 3074 794577
SGTC_1810 st050138 53 µM -0.405226731133017 0.344209674274019 no 2226 0.342655428864422 3238 3444541
SGTC_1129 3453-1384 223 µM -0.405531286813529 0.34408505125046 no 2227 0.342543512782448 3294 1084452
SGTC_2881 9058953 51.95 µM -0.407760421688973 0.343173414040952 no 2228 0.341724786589222 3086 17122249
SGTC_1700 st030840 7.9285 µM -0.407832558461851 0.343143927861246 no 2229 0.341698304293646 3217 5499307
SGTC_2293 7624732 200 µM -0.410037265217601 0.342243206987076 no 2230 0.340889305678279 3102 894453
SGTC_2111 5486399 200 µM -0.410322928234096 0.342126566441113 no 2231 0.340784537460522 3132 689674
SGTC_1057 3448-5381 134 µM -0.41090692991001 0.341888156574046 no 2232 0.340570390395755 3221 5497911
SGTC_70 0141-0289 43.283 µM -0.411056989847086 0.341826907046292 no 2233 0.340515373343668 3158 352408
SGTC_2223 6903751 107.57 µM -0.41193097373935 0.341470258365834 no 2234 0.340195008738794 3195 5598863
SGTC_1081 sertraline 6 µM -0.413407984707498 0.340867852780862 no 2235 0.339653862772748 3238 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2868 9035608 32.47 µM -0.414715484437498 0.340334921431453 no 2236 0.339175097789218 3081 6462614
SGTC_1204 4049-0315 18.3 µM -0.414982005029485 0.340226327839312 no 2237 0.33907753821269 3333 588402
SGTC_2996 9066192 71.4286 µM -0.415361980526924 0.340071530053705 no 2238 0.338938467247993 3159 6472854
SGTC_2680 butyl paraben 22.24 µM -0.417406750187839 0.33923897704935 no 2239 0.338190459168173 3207 7184 An antifungal and steroid mimetic.
SGTC_1670 st016595 4.04 µM -0.417777084865578 0.339088274515406 no 2240 0.338055053247268 3204 597879
SGTC_2097 5376186 200 µM -0.417950103576993 0.33901787578442 no 2241 0.337991799382981 3236 742755
SGTC_516 3992-2719 87.3 µM -0.418358896328734 0.338851566449234 no 2242 0.337842367123502 3041 5350887 YDR037W KRS1
SGTC_677 0929-0063 136 µM -0.418980901481116 0.338598576078208 no 2243 0.337615045106886 3199 1539583
SGTC_2589 lobaric acid 100 µM -0.419360811845357 0.338444089593757 no 2244 0.337476229747602 3126 73157 A novel microtubule depolymerizer.
SGTC_2185 6113692 200 µM -0.419636085490617 0.338332169495496 no 2245 0.33737566139049 3253 874150
SGTC_1669 st015249 58.4 µM -0.422620443285711 0.337119714989561 no 2246 0.336286104344683 3252 722793
SGTC_2124 5246320 200 µM -0.422928351460013 0.336994717157246 no 2247 0.336173768390642 3228 579342
SGTC_2022 5136654 200 µM -0.423383629289745 0.33680992639569 no 2248 0.336007693503996 3260 1713771
SGTC_1157 4092-0394 27.6 µM -0.424739530938383 0.33625981877883 no 2249 0.335513281479385 3338 3659885
SGTC_3167 9103034 49.47 µM -0.424925719932732 0.3361843067249 no 2250 0.335445412278105 3222 5127859
SGTC_1388 3346-4487 254 µM -0.42511098570052 0.336109175661152 no 2251 0.335377884938819 3225 3345614
SGTC_1166 k206-0078 225 µM -0.425256256079189 0.336050268557762 no 2252 0.335324939199808 3139 5404595
SGTC_3091 9116372 49.47 µM -0.425489749574884 0.335955595438997 no 2253 0.335239846215621 3305 17169793
SGTC_3121 9125696 49.47 µM -0.425925360456487 0.335778998895553 no 2254 0.335081117370376 3190 1235365
SGTC_2830 7992007 71.43 µM -0.427050472181571 0.335323046719031 no 2255 0.33467128301239 3042 1952075
SGTC_3072 9116419 49.47 µM -0.42785120690878 0.334998696151182 no 2256 0.334379726443001 3182 17170162
SGTC_2728 chlorpromazine 9.18 µM -0.428581462043296 0.334703001727297 no 2257 0.334113919356617 3162 2726 A thorazine and dopamine antagonist.
SGTC_1495 4469-0029 237 µM -0.429458830839471 0.334347873666986 no 2258 0.33379467407292 3175 793680
SGTC_2635 hydroquinidine 100 µM -0.431522543731117 0.333513139928196 no 2259 0.33304423218243 3130 442912 An experimental heart treatment.
SGTC_2379 9035213 200 µM -0.432586427296039 0.333083140140485 no 2260 0.332657625782257 3291 646551
SGTC_3134 9127454 49.47 µM -0.432897277219349 0.332957542399262 no 2261 0.332544699081522 3291 24262820
SGTC_1438 4092-1045 4 µM -0.433158610197232 0.332851966290977 no 2262 0.332449772835159 3179 1351342
SGTC_719 2810-4230 27.3 µM -0.434093657588521 0.332474324358828 no 2263 0.332110215491451 3216 721079
SGTC_2145 5634607 200 µM -0.434251076016874 0.332410763754017 no 2264 0.332053063396147 3153 308662
SGTC_2743 auranofin 4.32 µM -0.435109917022917 0.332064075703644 no 2265 0.33174132271633 3181 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_481 bay k-8644 50 µM -0.435445244537106 0.331928753153398 no 2266 0.331619637698459 3195 2303 A calcium channel antagonist.
SGTC_1126 isoteolin 1.0172 µM -0.436465564842929 0.331517134338967 no 2267 0.331249489020768 3144 133323
SGTC_1723 st034307 2.5525 µM -0.436508840179978 0.331499680644672 no 2268 0.331233793367418 3211 867466
SGTC_447 ml7 120 µM -0.436853456242106 0.331360704068546 no 2269 0.331108814184831 3264 4216 Selective myosin light chain kinase inhibitor.
SGTC_3047 9092122 49.47 µM -0.437384452627875 0.331146609596163 no 2270 0.330916278756151 3219 17173831
SGTC_1000 4048-0884 8.67 µM -0.437622236510993 0.331050754485503 no 2271 0.330830074540352 3276 13040088
SGTC_2581 avocatin a 64 µM -0.439216674021693 0.330408293343652 no 2272 0.330252272183518 3175 6710728 A skin care supplement.
SGTC_2759 disulfiram 3.38 µM -0.439595533727695 0.330255709351358 no 2273 0.330115038036732 3130 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1808 st050063 61.5 µM -0.440006408847905 0.330090263199856 no 2274 0.329966232796483 3302 4011993
SGTC_510 ag-490 170 µM -0.440367306396046 0.329944968808257 no 2275 0.329835549953017 3294 5328779
SGTC_2059 5238311 157 µM -0.440762440444969 0.329785920497898 no 2276 0.329692493714485 3113 703021
SGTC_37 0566-0070 1.56 µM -0.440940825133808 0.329714127645911 no 2277 0.329627918621674 3234 1626686
SGTC_1474 0330-0125 5.35 µM -0.441981858773974 0.329295277587114 no 2278 0.329251166768795 3281 X1474
SGTC_115 0527-0192 112.043 µM -0.442858701257599 0.328942654401998 no 2279 0.328933970426964 3284 4233931
SGTC_2958 9077254 16.72 µM -0.443849578122933 0.32854435532692 no 2280 0.328575670557137 3371 16457351
SGTC_2673 kobusone 100 µM -0.443859581989461 0.32854033510225 no 2281 0.328572053974006 3223 6710676 An epoxy ketone and protein crosslinker.
SGTC_275 trichlorophene 5.69 µM -0.444507204645543 0.32828011912506 no 2282 0.328337960566006 3276 62616
SGTC_2675 theaflavin digallate 100 µM -0.444904418142391 0.328120559211468 no 2283 0.32819441482404 3258 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1307 1187-1599 12.2 µM -0.447212764829209 0.327193922097853 no 2284 0.327360722863129 3160 1538471
SGTC_1892 st058411 7.36 µM -0.447273854210073 0.327169413482389 no 2285 0.32733867123958 3290 3934738
SGTC_1777 st045864 34.765 µM -0.448343603561089 0.326740358681146 no 2286 0.326952618207642 3275 4691462
SGTC_1065 prochlorperazine maleate 2.48 µM -0.448583890394428 0.326644015976526 no 2287 0.326865928518818 3295 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_854 0422-0053 192 µM -0.448913110463899 0.326512034371791 no 2288 0.326747169037051 3273 3596728
SGTC_121 0557-0495 61.343 µM -0.451664045105582 0.325410057502959 no 2289 0.325755512002319 3231 3104427
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.451683500997329 0.325402269227598 no 2290 0.325748502919805 3244 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1355 1499-0035 1.68 µM -0.452067545313882 0.325248550281488 no 2291 0.325610161640412 3193 1548538
SGTC_733 4069-0007 56.1 µM -0.45356355315577 0.324650036532799 no 2292 0.325071495576049 3295 5717425 YNL287W SEC21
SGTC_2826 7992541 19.48 µM -0.456662954351898 0.323411488089766 no 2293 0.323956660987465 3278 2985066
SGTC_108 0509-0257 621.132 µM -0.456905371112827 0.323314698411474 no 2294 0.323869531621725 3236 536624
SGTC_586 0957-0265 8.15 µM -0.458084970216694 0.322843890931244 no 2295 0.323445698234813 3269 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1848 st056003 16.4 µM -0.459227600458857 0.32238810919871 no 2296 0.323035366171019 3320 146492
SGTC_306 1672-3436 11.6 µM -0.459263585899529 0.322373759361673 no 2297 0.323022446866848 3302 6797378
SGTC_2855 9016525 58.44 µM -0.45964607862296 0.322221249919431 no 2298 0.322885139533851 3222 43811474
SGTC_2878 9043973 25.97 µM -0.46041287171644 0.321915600427554 no 2299 0.322609948674026 3348 6465167
SGTC_894 0960-0238 55.9 µM -0.461067588772593 0.321654720597367 no 2300 0.322375057142454 3330 6741907 YDL195W SEC31
SGTC_2137 5261020 140 µM -0.461280946346762 0.321569724710565 no 2301 0.322298526583623 3206 763655
SGTC_796 1234-0020 70.7 µM -0.464451451854515 0.320307783690088 no 2302 0.321162167210443 3267 46495034
SGTC_821 1114-0266 29.2 µM -0.464547212981155 0.320269700566392 no 2303 0.3211278708761 3284 3123235
SGTC_1675 st018485 24.5 µM -0.464611331613241 0.320244202365163 no 2304 0.32110490798436 3228 3323024
SGTC_335 4077-0256 27.6 µM -0.465156486628611 0.320027443635564 no 2305 0.320909698527721 3268 3121989
SGTC_31 0508-1974 57.237 µM -0.46524970270386 0.319990386199881 no 2306 0.320876324609781 3302 6810525
SGTC_3050 9093513 49.47 µM -0.465454640665208 0.319908920780854 no 2307 0.320802956274042 3266 25236664
SGTC_984 1492-0255 2.91 µM -0.465699433764563 0.319811623825194 no 2308 0.32071532886502 3298 1585198
SGTC_3118 9124250 49.47 µM -0.466496721453797 0.319494814972878 no 2309 0.320429996893171 3227 1504786
SGTC_620 0109-0052 432 µM -0.466814120738353 0.319368730382578 no 2310 0.320316436093149 3359 493037
SGTC_2939 9044578 71.43 µM -0.466918546911546 0.319327252398991 no 2311 0.320279077620717 3193 2653634
SGTC_841 0251-0215 91.2 µM -0.468142332702001 0.318841334389032 no 2312 0.319841403987968 3295 3888614
SGTC_2938 9059746 27.26 µM -0.468364481032856 0.318753161232067 no 2313 0.319761981928682 3297 6471769
SGTC_678 1218-2179 85.9 µM -0.469046312871871 0.318482598635186 no 2314 0.319518266289083 3281 6820081 YOR116C RPO31
SGTC_3009 9080819 71.4286 µM -0.470682051411018 0.317833904227839 no 2315 0.318933901812241 3277 17027216
SGTC_646 4092-0839 27.3 µM -0.473207632253932 0.316833417506595 no 2316 0.318032526568719 3378 877796
SGTC_1716 st033144 30.6155 µM -0.473395565088896 0.316759022961904 no 2317 0.3179654966611 3399 674617
SGTC_543 3844-1095 191 µM -0.474227449971959 0.316429804463278 no 2318 0.317668860351496 3311 4230703
SGTC_1416 3966-0321 25.3 µM -0.476000894312618 0.315728449424331 no 2319 0.317036870385855 3272 582530 YLR208W SEC13
SGTC_353 1988-1175 58.3 µM -0.476685864313246 0.315457737444371 no 2320 0.316792915091958 3153 2788357
SGTC_2864 9034755 47.6 µM -0.477578091234525 0.315105262455428 no 2321 0.316475263717281 3342 4930451
SGTC_1933 st074711 15.9 µM -0.478269198166924 0.314832355720305 no 2322 0.316229308246031 3307 17250958
SGTC_1884 5633444 25 µM -0.478396114646464 0.314782249476958 no 2323 0.31618414924448 3352 5724239
SGTC_1813 st051246 8.6015 µM -0.478434025259364 0.314767283142652 no 2324 0.316170660547503 3302 5291959
SGTC_2241 6772625 37.8075 µM -0.478687664341742 0.314667159450723 no 2325 0.316080421381596 3324 2285411
SGTC_2174 5790901 200 µM -0.479446146279068 0.314367831027279 no 2326 0.31581063569694 3314 786020
SGTC_1 0258-0098 57.368 µM -0.481392857237662 0.313600136963537 no 2327 0.315118656124145 3249 6790032 YDR047W HEM12
SGTC_785 1270-0111 65.3 µM -0.482233154899137 0.313269010887757 no 2328 0.314820163343898 3237 6741994
SGTC_356 1634-0012 32.5 µM -0.482307103022297 0.313239878233653 no 2329 0.314793901081027 3351 735457
SGTC_3242 9133940 49.47 µM -0.482372953874452 0.313213936567136 no 2330 0.314770515307136 3371 17248444
SGTC_2058 5236698 133 µM -0.483232146800716 0.312875545873234 no 2331 0.314465456129541 3248 766665
SGTC_2931 9014674 55.67 µM -0.485468910560006 0.311995342582761 no 2332 0.313671880426167 3198 2996810
SGTC_888 0916-0002 6.97 µM -0.485671936998137 0.311915501359865 no 2333 0.313599891784286 3393 2802138 YIL048W NEO1
SGTC_1109 tnp00067 928.257 nM -0.487435607795009 0.311222300612432 no 2334 0.312974832389288 3295 676295
SGTC_2618 avocadyne 43.43 µM -0.488359144716577 0.310859576394747 no 2335 0.312647737505362 3280 3015189
SGTC_2446 5162541 200 µM -0.488411570072117 0.310838991554422 no 2336 0.312629174109141 3229 1549321
SGTC_3229 9132204 49.47 µM -0.488641034137548 0.310748899348918 no 2337 0.312547928325127 3251 17682924
SGTC_2144 5628481 200 µM -0.489467338020686 0.31042456985299 no 2338 0.312255436402947 3269 2818399
SGTC_2131 toluylene red 5.2905 µM -0.490093618247882 0.310178849045394 no 2339 0.312033826882954 3253 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2263 7948595 193.29 µM -0.492765771989877 0.309131383591556 no 2340 0.311089049109304 3309 2971371
SGTC_1965 Pectolinarigenin 58.4 µM -0.493240141841625 0.308945595687641 no 2341 0.310921458727714 3273 5320438 An anti-inflammatory.
SGTC_2078 5212016 200 µM -0.493723575769009 0.308756308096259 no 2342 0.310750706432954 3308 1899708
SGTC_905 2-aminofluorene 215 µM -0.494644288739533 0.308395945286433 no 2343 0.310425616812837 3350 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1484 3473-2379 286 µM -0.497380492515896 0.307326097840121 no 2344 0.309460379644539 3429 671917
SGTC_1078 idebenone 36.1 µM -0.497542489402611 0.307262808801409 no 2345 0.309403273905755 3335 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1070 indatraline 8.81 µM -0.497560603791017 0.307255732218283 no 2346 0.309396888664598 3291 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_488 nitrendipine 139 µM -0.498045792677444 0.307066214607674 no 2347 0.309225883164722 3346 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2317 5986382 200 µM -0.500623004950993 0.306060405254227 no 2348 0.308318234457212 3345 877883
SGTC_2569 tetrandrine 100 µM -0.500632058208335 0.306056874606819 no 2349 0.308315048119756 3264 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_877 0771-0151 33.1 µM -0.501246977792708 0.30581710650675 no 2350 0.308098658028525 3322 6166523
SGTC_1013 4112-3890 241 µM -0.501798806317649 0.305602009569338 no 2351 0.307904526442723 3209 705171
SGTC_1455 4262-0120 131 µM -0.501980243611207 0.305531301874121 no 2352 0.3078407090975 3459 1529587
SGTC_580 1123-0028 41 µM -0.502485994606442 0.305334244591691 no 2353 0.307662850853721 3379 1677248 YPR107C YTH1
SGTC_2370 9071495 200 µM -0.503934020771247 0.304770357848713 no 2354 0.307153871278727 3335 21791103
SGTC_3284 9108171 64.8615 µM -0.504959772121117 0.304371192643235 no 2355 0.306793545434204 3326 8687505
SGTC_2947 9072639 7.68 µM -0.505035989998226 0.304341542188695 no 2356 0.306766779068733 3377 16488146
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.505344252862174 0.304221634179112 no 2357 0.306658533134425 3397 6708760
SGTC_419 nsc-638432 893 µM -0.505746233632588 0.304065303423941 no 2358 0.306517403661325 3317 368090
SGTC_1912 st060209 90.8 µM -0.505909468133173 0.304001831574092 no 2359 0.306460102643914 3303 688787
SGTC_211 3455-0679 143.504 µM -0.508309560390739 0.303069266220046 no 2360 0.305618133207302 3384 748649
SGTC_1380 2291-0730 164 µM -0.508945583297785 0.302822351676817 no 2361 0.305395183764706 3315 2999191
SGTC_3065 9113888 49.47 µM -0.509608354478042 0.30256514889832 no 2362 0.305162934841688 3468 16648368
SGTC_1325 1431-0015 227 µM -0.509722524209075 0.302520852737729 no 2363 0.305122935290002 3258 1103340
SGTC_1617 st002906 78 µM -0.509728822430841 0.302518409205805 no 2364 0.305120728765465 3360 5150859
SGTC_451 chloral hydrate 100 µM -0.510273923531832 0.302306958925006 no 2365 0.30492978441223 3378 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2730 imipramine 71.33 µM -0.510373838000704 0.302268208274595 no 2366 0.304894790967743 3410 3696 A tricyclic antidepressant.
SGTC_862 0452-0056 10.2 µM -0.51143236379391 0.30185780847195 no 2367 0.304524168884082 3368 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1876 myriocin 605 nM -0.512122761410505 0.301590270211676 no 2368 0.304282547734256 3440 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1844 rapamycin 4 nM -0.51220018301933 0.301560274960868 no 2369 0.304255457516205 3331 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1435 4092-0789 56.7 µM -0.512733717949968 0.301353605425472 no 2370 0.304068800123206 3392 2248285
SGTC_18 0111-0177 500 nM -0.51298086665966 0.301257891774981 no 2371 0.303982352356125 3403 721752
SGTC_2925 9010536 32.5 µM -0.513012602691008 0.301245602306649 no 2372 0.303971252509253 3317 2994177
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.513782618885896 0.300947490284608 no 2373 0.30370199062803 3299 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1992 st073643 23.3 µM -0.514189386788157 0.300790063671747 no 2374 0.303559793628864 3341 3161292
SGTC_3193 9111931 49.47 µM -0.514267983620111 0.300759649544712 no 2375 0.303532321354561 3290 17087244
SGTC_1466 k213-0079 57.5 µM -0.514841107749217 0.300537913229871 no 2376 0.303332028495674 3362 3657981
SGTC_143 4032-1194 15.74 µM -0.516039381712758 0.300074551042945 no 2377 0.302913452051086 3343 1806963
SGTC_1442 4112-3290 3 µM -0.516959507327663 0.299718965916596 no 2378 0.302592212920304 3324 704353
SGTC_1959 st077091 55.8 µM -0.517018621469357 0.299696127616519 no 2379 0.30257157989834 3299 821356 YKL052C ASK1
SGTC_3017 9080681 49.47 µM -0.517902397143112 0.299354781623209 no 2380 0.302263184715621 3361 16451914
SGTC_1226 3909-7979 35.4 µM -0.517922602104998 0.299346979801341 no 2381 0.302256135805582 3411 6615510
SGTC_3192 9110362 49.47 µM -0.518437204346912 0.299148305495246 no 2382 0.30207663126396 3435 16649480
SGTC_1708 st033234 31.827 µM -0.518747153153051 0.299028671350765 no 2383 0.301968537430063 3447 674664
SGTC_2342 7990637 118.86 µM -0.518849916877905 0.298989011369661 no 2384 0.301932702686041 3404 2033102 YER133W GLC7
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.519013425358727 0.298925912866924 no 2385 0.301875689573509 3217 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1704 st028805 70.8 µM -0.519541349097197 0.29872222652968 no 2386 0.301691643008843 3364 2876101
SGTC_1224 0823-0416 294 µM -0.519711676059792 0.298656523541538 no 2387 0.301632273812672 3422 3598164
SGTC_3337 9144342 33.5465 µM -0.520288649531739 0.298434007029115 no 2388 0.301431202896695 3389 17682949
SGTC_294 k038-0071 157 µM -0.520793000379043 0.298239560093869 no 2389 0.301255489852217 3369 24152826
SGTC_2000 st075254 36.4 µM -0.520899288904744 0.29819858908056 no 2390 0.301218465404255 3379 17234175
SGTC_652 0437-0092 114 µM -0.520942821112049 0.298181809470708 no 2391 0.301203302026599 3375 3091274
SGTC_509 pifithrin 175 µM -0.521929528865355 0.29780159563748 no 2392 0.300859698829557 3438 4817 A p53 inhibitor.
SGTC_3209 9113616 49.47 µM -0.522585301301075 0.297549025413322 no 2393 0.300631435736196 3468 16649353
SGTC_1114 scopoletin 1.73284 µM -0.522761413573443 0.297481212574961 no 2394 0.300570147406209 3432 5280460 A coumarin with genotoxic properties.
SGTC_2031 5180455 200 µM -0.52278413107939 0.297472465608985 no 2395 0.30056224196253 3349 29949
SGTC_2017 5132927 60.65 µM -0.523321093293763 0.297265752196273 no 2396 0.300375412325769 3289 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1660 st012960 28.1 µM -0.524540681179491 0.296796493600023 no 2397 0.299951266248988 3374 24207266
SGTC_1313 1220-0047 237 µM -0.524799362936453 0.296697004699573 no 2398 0.299861337226754 3359 3528706
SGTC_1762 st045503 25.4615 µM -0.525338123546423 0.296489846623934 no 2399 0.299674079815632 3378 4645554
SGTC_2214 7179297 48.276 µM -0.525614839636408 0.29638347268486 no 2400 0.299577922002091 3384 769744
SGTC_761 k216-0224 480 µM -0.526170506645875 0.296169918562604 no 2401 0.299384872022565 3486 1340404
SGTC_879 0831-1030 162 µM -0.526770119540307 0.295939554365755 no 2402 0.299176617659538 3424 1549252
SGTC_1645 Cervolide 78 µM -0.528711879382362 0.29519411836775 no 2403 0.298502667576004 3378 23173 A fragrance.
SGTC_3212 9128307 49.47 µM -0.53016052068459 0.294638552806131 no 2404 0.29800032042222 3205 27243542
SGTC_2452 5863136 48.41 µM -0.531069007335257 0.294290387157413 no 2405 0.297685480092005 3350 2184096
SGTC_2024 5144227 134 µM -0.531144586349411 0.294261431050373 no 2406 0.297659294668377 3409 3475211
SGTC_1578 josamycin 24.2 µM -0.532715615867121 0.293659830721996 no 2407 0.297115227340312 3327 5282165 A P450 substrate.
SGTC_2477 5967686 25.23 µM -0.533464943232639 0.293373088608045 no 2408 0.296855886084325 3307 776118
SGTC_286 k060-0067 22.9 µM -0.533514155202261 0.293354261400672 no 2409 0.296838857509653 3349 5985051
SGTC_2882 9058044 58.44 µM -0.533609613077944 0.29331774332034 no 2410 0.29680582796735 3376 18076804
SGTC_3161 9100388 49.47 µM -0.534116520727942 0.293123857548813 no 2411 0.296630460180251 3398 25236368
SGTC_1573 oleylamine 1.06 µM -0.534994214300024 0.292788291470221 no 2412 0.296326929027753 3410 5356789 An amine of the fatty acid oleic acid.
SGTC_708 3448-5400 146 µM -0.535723633990701 0.292509550306918 no 2413 0.2960747835696 3408 3462195
SGTC_2165 5727197 32.143 µM -0.538227944985826 0.291553490299975 no 2414 0.295209844810741 3599 1361712
SGTC_90 0870-0863 4.608 µM -0.538371311272959 0.291498802096138 no 2415 0.295160364193342 3376 1738164
SGTC_1053 3366-3204 134 µM -0.539907369303328 0.290913161084337 no 2416 0.294630457746211 3361 3632071 YPR165W RHO1
SGTC_346 4513-0042 7.16 µM -0.54258226737698 0.28989463794514 no 2417 0.29370872544595 3405 2827372
SGTC_741 4582-0002 126 µM -0.543088679046989 0.289701999602605 no 2418 0.293534373453772 3373 2912688
SGTC_3313 9133968 57.047 µM -0.543265749788831 0.289634656300461 no 2419 0.293473421247892 3408 1494643
SGTC_3247 9135149 49.47 µM -0.544833236239636 0.28903883269629 no 2420 0.292934108792292 3384 8934436 YOR116C RPO31
SGTC_1187 1391-0724 117 µM -0.546466147726634 0.288418753948252 no 2421 0.292372775695692 3426 6997986
SGTC_3222 9128301 49.47 µM -0.546725895208745 0.288320175761834 no 2422 0.292283530481573 3343 4911358
SGTC_1853 st056710 91.2 µM -0.547457516249202 0.288042599693421 no 2423 0.292032224949145 3481 269167
SGTC_2435 5706476 10.6 µM -0.548265533075712 0.28773618581569 no 2424 0.29175479507212 3467 5725375
SGTC_3112 9123419 49.47 µM -0.549388379564354 0.287310639001875 no 2425 0.291369473528509 3467 17015854
SGTC_3088 9117578 49.47 µM -0.549408540789676 0.287303000835277 no 2426 0.291362557073517 3478 678341
SGTC_1046 2001-0062 216 µM -0.55087279283751 0.286748519737758 no 2427 0.290860439716454 3397 739778
SGTC_1898 st060199 18.6 µM -0.551430808117436 0.286537344807964 no 2428 0.2906691931251 3431 688866
SGTC_1721 st082152 9.2685 µM -0.551621618216755 0.286465151692554 no 2429 0.290603810956305 3419 5296051
SGTC_740 k014-0057 261 µM -0.551709057767603 0.286432071770191 no 2430 0.29057385159467 3424 4012779
SGTC_3019 9081971 49.47 µM -0.552812540938602 0.28601476052639 no 2431 0.290195890067187 3510 16451803
SGTC_2315 7733312 200 µM -0.553077415717673 0.285914634166655 no 2432 0.290105200296153 3353 726316
SGTC_1668 st014914 51.6 µM -0.554594852288389 0.285341343403676 no 2433 0.289585905415757 3460 2839556
SGTC_2012 4023501 200 µM -0.554768971947617 0.285275595660159 no 2434 0.28952634636836 3364 3477460
SGTC_1797 st048695 56.8 µM -0.555801797902348 0.284885748084359 no 2435 0.289173178152233 3430 592262 YIL048W NEO1
SGTC_1267 0828-0272 9.49 µM -0.555817353109256 0.284879878602937 no 2436 0.289167860697493 3514 745334
SGTC_2603 homopterocarpin 100 µM -0.556294732803709 0.284699775900835 no 2437 0.289004693654748 3446 101795 A weak amylase inhibitor.
SGTC_2266 7929956 200 µM -0.556458866211181 0.284637865276245 no 2438 0.288948603323349 3458 2967153
SGTC_2098 5376439 882.5 nM -0.55652323742139 0.284613586405466 no 2439 0.288926606747281 3442 2844116
SGTC_2472 5377652 49.4 µM -0.557123168400105 0.284387358176977 no 2440 0.288721639534248 3424 1610903
SGTC_2433 5607874 27.82 µM -0.557845262802433 0.284115177296179 no 2441 0.288475025867972 3420 2252428
SGTC_3239 9133757 49.47 µM -0.557992658817274 0.284059634256333 no 2442 0.288424698570369 3436 17036923
SGTC_2790 5423970 71.43 µM -0.558671967612652 0.283803718402384 no 2443 0.288192807028273 3487 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3246 9135460 32.98 µM -0.55903823481929 0.283665780456674 no 2444 0.288067813108952 3403 41446951
SGTC_2626 ethyl orsellinate 100 µM -0.559546640632813 0.283474365686311 no 2445 0.287894354775396 3383 75653 A natural product.
SGTC_150 3970-0969 77.2 µM -0.559925907594879 0.283331612018176 no 2446 0.287764988275973 3460 6615640
SGTC_1298 1079-1278 263 µM -0.561783302907248 0.282632998504441 no 2447 0.287131834807041 3447 2840950
SGTC_949 1165-0505 146 µM -0.563632623660192 0.28193824562449 no 2448 0.2865020898335 3401 6244267
SGTC_2912 7964298 10.93 µM -0.563714324947152 0.281907571068324 no 2449 0.286474283402418 3461 2975850
SGTC_983 1491-0821 12.2 µM -0.563900512410106 0.281837673430755 no 2450 0.286410920655885 3457 46495113
SGTC_1173 0443-0020 122 µM -0.564350011270205 0.281668959072652 no 2451 0.286257976000948 3404 5331295
SGTC_2986 9022445 71.43 µM -0.564440021604589 0.281635180555568 no 2452 0.286227354111658 3474 6459286
SGTC_2319 6033012 152.6 µM -0.564615043484976 0.281569505027985 no 2453 0.286167815395343 3343 847246
SGTC_2351 9026858 72.31 µM -0.56712326532196 0.280629127683065 no 2454 0.285315218648939 3382 1409300
SGTC_1139 k015-0024 46.9 µM -0.567751646741165 0.280393774462086 no 2455 0.285101808443685 3468 2766652
SGTC_1752 st044819 83.042 µM -0.56777151990628 0.280386332750015 no 2456 0.285095060382754 3380 441209 YML126C ERG13
SGTC_1681 tripelennamine 100 µM -0.567884987706562 0.280343845391335 no 2457 0.28505653312046 3475 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2036 5160441 105 µM -0.568965160189322 0.279939537265874 no 2458 0.284689891846396 3438 134534 YIL048W NEO1
SGTC_2628 lathosterol 100 µM -0.569619337078124 0.279694816664636 no 2459 0.284467955101221 3518 6710616
SGTC_1743 st037606 46.3785 µM -0.569832987292281 0.279614914892745 no 2460 0.284395489811842 3430 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2749 bexarotene 57.39 µM -0.571494944016617 0.278993748196377 no 2461 0.283832093310733 3427 82146 An retinoic acid receptor inhibitor.
SGTC_3051 9093778 49.47 µM -0.571555040447205 0.278971299360199 no 2462 0.28381173088133 3444 17217378
SGTC_3293 9120939 62.045 µM -0.571566193112189 0.278967133413273 no 2463 0.283807952108991 3483 934087
SGTC_197 4544-0043 41.561 µM -0.571786541710263 0.278884830990183 no 2464 0.283733298015378 3457 896523
SGTC_1182 1222-0449 220 µM -0.572641912261184 0.278565453458186 no 2465 0.283443587658802 3456 658318
SGTC_2170 morpholine 200 µM -0.574938602902518 0.277708799402243 no 2466 0.282666410596586 3477 121171 Reacts with secondary amines.
SGTC_2676 harmalol 100 µM -0.576377071976926 0.27717291378013 no 2467 0.282180169239324 3498 5459187 A monoamine oxidase inhibitor
SGTC_2247 cerulenin 830 nM -0.576695965588173 0.27705418206698 no 2468 0.282072429141488 3562 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1292 0kpi-0043 232 µM -0.576837252474215 0.277001585541375 no 2469 0.282024700862094 3439 3333905
SGTC_2340 7987427 183.45 µM -0.577953814351713 0.276586097798495 no 2470 0.281647650742487 3462 2239331
SGTC_3041 9091929 49.47 µM -0.579609246414957 0.275970651939324 no 2471 0.281089078098394 3569 25236887
SGTC_1347 1493-0251 600 nM -0.58062618103578 0.275592916327782 no 2472 0.280746211561907 3506 3986378
SGTC_1007 4101-0031 70 µM -0.581049979903984 0.275435573305657 no 2473 0.280603384577397 3503 1146276
SGTC_2890 9046729 58.44 µM -0.581246090266066 0.27536277873419 no 2474 0.280537304155158 3367 903329
SGTC_1696 st025591 34.7925 µM -0.583819574386013 0.27440840056209 no 2475 0.279670853653917 3497 2787147
SGTC_2407 paclitaxel 400 µM -0.584642159775509 0.274103688958745 no 2476 0.279394176618323 3528 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1120 ficusin 1.78878 µM -0.585787645252392 0.273679643635792 no 2477 0.279009113596789 3498 6199 A DNA cross-linker.
SGTC_2704 st078022 71.1 µM -0.586074057915402 0.273573667758349 no 2478 0.278912874312812 3536 54697681
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.586078767265367 0.273571925416092 no 2479 0.278911292030078 3485 442882
SGTC_248 streptozotocin 5.23457 mM -0.589254758324384 0.272398140004904 no 2480 0.277845194505726 3519 5300 DNA alkylating agent.
SGTC_374 0880-0231 82.3 µM -0.592179195619943 0.271319540771353 no 2481 0.276865299601895 3498 6833587
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.592303144415769 0.271273872687537 no 2482 0.276823805337594 3474 688667
SGTC_1816 st051957 91.6 µM -0.592594416709219 0.271166570491542 no 2483 0.276726308276815 3502 674121
SGTC_2792 7535235 81.82 µM -0.59369029889874 0.270763046655215 no 2484 0.27635963636445 3426 1281891
SGTC_1393 3470-5649 58.2 µM -0.593825349756752 0.270713339218963 no 2485 0.276314466112709 3427 4108395
SGTC_1925 st057770 10.1 µM -0.594140152331316 0.270597489236182 no 2486 0.27620918864601 3394 5989122
SGTC_1366 1683-0113 21.9 µM -0.595466691184785 0.270109584029146 no 2487 0.275765778877655 3490 708623
SGTC_948 3448-0295 75.3 µM -0.595934663665378 0.269937567332702 no 2488 0.275609437598537 3532 678569
SGTC_1896 st058441 89 µM -0.596532487354705 0.269717899893487 no 2489 0.275409778761436 3435 688759
SGTC_594 1487-1584 10.8 µM -0.598650560079055 0.268940345494122 no 2490 0.274702966283852 3429 5013332
SGTC_1227 3909-8010 46.6 µM -0.598747961839349 0.268904615936681 no 2491 0.274670484307968 3471 15982272
SGTC_1104 tacrolimus 29.8 µM -0.599345536854473 0.268685461699826 no 2492 0.274471243780111 3540 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3020 9089140 49.47 µM -0.600115532631296 0.268403206372349 no 2493 0.274214620769287 3530 17217859
SGTC_782 0083-0095 30.5 µM -0.60033809960857 0.2683216483682 no 2494 0.274140466071049 3537 3591729 An indicator and reagent.
SGTC_1051 3253-3903 78 µM -0.600535587052638 0.268249291010642 no 2495 0.274074675648595 3463 5509239
SGTC_2735 sertaconazole 140 nM -0.601190941782478 0.268009246176289 no 2496 0.273856408495503 3545 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2779 methotrexate 400 µM -0.601569522304128 0.267870628133922 no 2497 0.273730360700515 3575 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1769 st044406 64.4 µM -0.601851907513734 0.26776725572376 no 2498 0.273636359673981 3451 670903
SGTC_523 1934-0222 13.7 µM -0.601937723097324 0.267735845300152 no 2499 0.273607796353354 3508 1361595
SGTC_3240 9133527 49.47 µM -0.602428758465301 0.267556151083204 no 2500 0.273444385877776 3507 17617455
SGTC_3124 9127567 49.47 µM -0.602746694535736 0.267439834931971 no 2501 0.273338606476424 3517 17592030
SGTC_2586 curcumin 80 µM -0.603573632861134 0.267137421003256 no 2502 0.273063573646228 3505 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3267 9137951 49.47 µM -0.604328768956106 0.266861416250695 no 2503 0.272812541521876 3489 16643986
SGTC_1514 1189-1591 158 µM -0.606920979470685 0.265915052182559 no 2504 0.271951677280399 3558 767698 YMR146C TIF34
SGTC_769 0302-0231 76 µM -0.60699138174367 0.265889373463781 no 2505 0.271928315786352 3552 571869 YER009W NTF2
SGTC_2853 9015042 58.44 µM -0.607432653512671 0.265728451410177 no 2506 0.271781911894278 3453 6457456
SGTC_3295 9122362 53.5725 µM -0.608443309721341 0.265360073587184 no 2507 0.271446747126294 3517 4730473
SGTC_2734 clemastine 41.6 µM -0.609193287332826 0.26508687910263 no 2508 0.271198164585508 3466 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1970 st070122 35.8 µM -0.609808863302317 0.264862749936005 no 2509 0.270994214753565 3590 102928
SGTC_787 4152-0075 138 µM -0.610817080277514 0.264495869673402 no 2510 0.270660342262406 3478 9566539
SGTC_3325 9138760 55.175 µM -0.611508433190944 0.264244442678582 no 2511 0.270431518543964 3467 43844959
SGTC_1311 1190-0148 100 µM -0.611544510945264 0.264231325483978 no 2512 0.270419580197571 3573 1961333
SGTC_978 1416-0512 87.4 µM -0.61165970919069 0.264189443783187 no 2513 0.270381462167005 3545 6814003
SGTC_1063 disulfiram 1.84 µM -0.612330812604989 0.26394552334671 no 2514 0.270159453682386 3530 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_947 3447-0010 211 µM -0.612448911192855 0.263902610905006 no 2515 0.270120394790286 3558 748350
SGTC_1396 3511-0007 98.6 µM -0.613403670039514 0.263555819255409 no 2516 0.269804729982353 3506 X1396
SGTC_2106 5357045 167.29 µM -0.613644010407067 0.263468558436468 no 2517 0.269725297146637 3511 668842
SGTC_144 4161-2749 112.381 µM -0.613656865703743 0.263463891455795 no 2518 0.269721048782687 3478 797501 YMR168C CEP3
SGTC_734 2023-0417 80 µM -0.61443482370266 0.263181540527459 no 2519 0.269464014919872 3510 3935732
SGTC_2336 9001819 198.65 µM -0.614714053842 0.263080234865083 no 2520 0.269371788475167 3632 2989602
SGTC_562 3772-2733 112 µM -0.61507461691132 0.262949450819154 no 2521 0.269252722133285 3554 2876874 YIL048W NEO1
SGTC_850 0388-0143 75.9 µM -0.615272089281115 0.262877837396427 no 2522 0.269187523336575 3502 67273
SGTC_46 0329-0187a 2.197 µM -0.617310113886674 0.26213933010053 no 2523 0.268515098535264 3524 46494817
SGTC_1534 6-azauridine 81.6 µM -0.617587879999989 0.262038759973833 no 2524 0.268423517952242 3544 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2677 mitomycin C 100 µM -0.618180837987832 0.26182413525784 no 2525 0.268228069931234 3546 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_40 0327-0103 19.753 µM -0.618424332242112 0.261736027168312 no 2526 0.268147831245226 3469 409036
SGTC_2049 5262831 67.185 µM -0.619677241812971 0.261282904057791 no 2527 0.267735150916754 3544 763417
SGTC_814 3342-0569 96 µM -0.619893523252954 0.26120472524002 no 2528 0.267663945063202 3599 4346283
SGTC_350 k064-0020 19.8 µM -0.620780487834724 0.260884241706484 no 2529 0.267372031571361 3560 2790705
SGTC_2390 9097792 176.6 µM -0.621956291663546 0.260459704970932 no 2530 0.266985304425133 3469 4497149
SGTC_428 3448-4153 16.5 µM -0.622327308009105 0.260325819373934 no 2531 0.266863334149405 3499 3834874
SGTC_2524 avocatin b 10.57 µM -0.622735692362776 0.260178490096926 no 2532 0.266729111833054 3493 6710748
SGTC_1072 oxiconazole 14.9 nM -0.623072420442106 0.260057043965708 no 2533 0.266618466216472 3575 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2519 cryptotanshinone 88.04 µM -0.624276720131472 0.259622934191194 no 2534 0.266222934905799 3559 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_638 3970-0837 4.09 µM -0.624400081567173 0.259578487650616 no 2535 0.266182435763541 3523 4118451 YLR208W SEC13
SGTC_3130 9127414 49.47 µM -0.624492952692785 0.259545029216612 no 2536 0.266151948545163 3564 1494646
SGTC_2867 9039098 71.43 µM -0.625582588075748 0.259152635574605 no 2537 0.265794381194567 3534 6463460
SGTC_2224 6650123 117.647 µM -0.626609494799796 0.258783112348231 no 2538 0.265457621468975 3526 2908370
SGTC_2987 9018338 71.43 µM -0.628171774533068 0.258221463351789 no 2539 0.264945709178928 3613 5055682
SGTC_3352 9151559 45.5865 µM -0.628455404005643 0.258119564657232 no 2540 0.264852826127172 3507 17159339
SGTC_330 1488-0319 80.1 µM -0.628666179682839 0.258043853430068 no 2541 0.264783811977047 3534 6846614
SGTC_101 0490-5701 117.494 µM -0.62922122082348 0.257844536174401 no 2542 0.264602118948221 3518 4661669
SGTC_204 PMA1.184 62.41 µM -0.629678592553609 0.257680352414987 no 2543 0.264452445734385 3581 2252213 YGL008C PMA1
SGTC_771 0250-0039 27.3 µM -0.629828294498601 0.257626625363426 no 2544 0.264403465685463 3512 3005115
SGTC_914 3820-6779 408 µM -0.630687868096714 0.257318242632871 no 2545 0.264122316546027 3534 2893481
SGTC_1149 3909-7961 23.3 µM -0.630900094191319 0.25724213342078 no 2546 0.264052925132691 3529 735261
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.631094057553099 0.257172583885811 no 2547 0.263989513197535 3594 551469
SGTC_3276 9139060 49.47 µM -0.634217957685733 0.256053793739897 no 2548 0.262969294845896 3616 4870619
SGTC_372 0155-0182 15.9 µM -0.635370150285509 0.255641790560076 no 2549 0.262593515658668 3560 771486
SGTC_1092 toremifene 6.32 µM -0.637350879021695 0.254934327874976 no 2550 0.261948158355529 3590 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_410 α-linolenic acid 100 µM -0.638131317570829 0.254655857983451 no 2551 0.26169410086002 3608 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2250 alverine citrate 130 µM -0.638613670336194 0.254483828384596 no 2552 0.261537142983765 3521 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2240 6690706 185.951 µM -0.63903992428187 0.254331856949649 no 2553 0.261398479931049 3510 805876
SGTC_2210 7115885 190.385 µM -0.63982923197781 0.254050572371139 no 2554 0.261141812966028 3588 2927039
SGTC_1165 k072-0275 30.3 µM -0.641549846710054 0.253437965209556 no 2555 0.260582752989697 3619 6153523 YGL055W OLE1
SGTC_1282 0886-0010 32.4 µM -0.64403134618051 0.252555821937418 no 2556 0.259777553771822 3650 2836211 YNL267W PIK1
SGTC_2451 5856223 45.7 µM -0.645539685377399 0.252020416990734 no 2557 0.259288754613646 3563 2179896
SGTC_1080 nisoldipine 24.4 µM -0.645661489317116 0.2519772072202 no 2558 0.259249303033228 3560 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_729 4092-0585 94.1 µM -0.646818964757511 0.251566789660729 no 2559 0.258874558410958 3559 2169061
SGTC_2232 chlorophetanol 41.5365 µM -0.647333892141717 0.251384320314906 no 2560 0.258707935473941 3632 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2423 st077119 87.2 µM -0.647600133306838 0.251290002706423 no 2561 0.258621805521328 3548 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_979 1426-2828 121 µM -0.647876185001205 0.251192229416618 no 2562 0.258532517507953 3639 747872
SGTC_2480 5767542 37.17 µM -0.651484126768384 0.249916203665403 no 2563 0.25736701018448 3599 2867358
SGTC_2178 5812956 200 µM -0.652694194536549 0.249489009048845 no 2564 0.256976722960901 3586 5403383
SGTC_289 k017-0060 526 µM -0.654815972135609 0.248740887913505 no 2565 0.256293122919814 3576 5512909
SGTC_3002 9075603 71.4286 µM -0.654905082448028 0.24870949451738 no 2566 0.256264433873766 3587 20105405
SGTC_2889 9059656 51.95 µM -0.655278186406662 0.248578073607262 no 2567 0.256144331315617 3649 3949838
SGTC_1571 st070080 73.4 µM -0.656017087691884 0.248317914671355 no 2568 0.255906564869029 3642 4315245
SGTC_611 3453-1652 23.7 µM -0.657264891532033 0.247878906552385 no 2569 0.25550530346613 3608 1560575
SGTC_1433 4060-0023 7.6 µM -0.65754429690558 0.247780661659295 no 2570 0.255415498996809 3618 3840627
SGTC_1503 4585-0012 61.3 µM -0.65761588831033 0.24775549193961 no 2571 0.255392491256397 3618 2922052
SGTC_1240 0356-0016 42.1 µM -0.658342881286631 0.247499977009997 no 2572 0.255158914712346 3578 4305613
SGTC_1575 cyproterone acetate 48 µM -0.658661696132851 0.247387968151739 no 2573 0.255056517514527 3551 9880 An androgen receptor antagonist and liver toxin.
SGTC_508 roscovitine 141 µM -0.660792295318864 0.246640123209109 no 2574 0.254372762264042 3645 160355 A CDKinase inhibitor.
SGTC_2587 piperic acid 92.2 µM -0.661649046685905 0.246339743308585 no 2575 0.254098083353334 3566 5370536
SGTC_812 4251-0442 148 µM -0.663431186849779 0.24571554770236 no 2576 0.2535272188127 3618 5723007
SGTC_2369 9071472 200 µM -0.66374615231005 0.245605319246682 no 2577 0.253426397528496 3631 17296037
SGTC_2391 6285546 200 µM -0.664352221575554 0.24539328794328 no 2578 0.253232452438848 3590 846083
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.665431031611261 0.245016113389002 no 2579 0.25288742122217 3602 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2181 6316240 54.2555 µM -0.665866799111606 0.244863848433814 no 2580 0.252748121753268 3603 12779990
SGTC_1483 3453-0561 55.9 µM -0.666612312252373 0.244603470947794 no 2581 0.252509901270748 3630 4546991
SGTC_1440 4100-1550 40 µM -0.66740993014175 0.244325060584879 no 2582 0.252255162349717 3630 742806
SGTC_3275 9138069 49.47 µM -0.668191767022433 0.244052324467471 no 2583 0.252005595056202 3637 17617007
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.669424073354682 0.243622780113131 no 2584 0.251612499717619 3659 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2431 5490079 200 µM -0.66971010745415 0.243523135771547 no 2585 0.251521303588414 3647 5722345
SGTC_1920 st075728 45.7 µM -0.669904428210312 0.24345545373206 no 2586 0.251459358349346 3643 3400306
SGTC_404 fumagillin 50 µM -0.670099743139078 0.243387435663607 no 2587 0.251397104314898 3611 12015870 A methionine aminopeptidase binder.
SGTC_2593 nobiletin 86.24 µM -0.671275448168544 0.242978215556236 no 2588 0.251022536157793 3584 72344 An anti-infammatory.
SGTC_1910 st062352 60.4 µM -0.674490759476595 0.241860986083134 no 2589 0.249999679274407 3598 2245730
SGTC_2732 terfenadine 20 µM -0.674543551759813 0.241842665549153 no 2590 0.249982903433688 3625 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1547 harmine 94.2 µM -0.676358479941833 0.241213288217346 no 2591 0.249406535902876 3676 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2949 9072542 2.23 µM -0.676633559313057 0.241117974467331 no 2592 0.249319240507951 3653 16457352
SGTC_1153 4055-0057 267 µM -0.676977412142848 0.240998859826793 no 2593 0.24921014296442 3643 882706
SGTC_420 mitomycin C 81.9 mM -0.677164116911586 0.240934196519702 no 2594 0.249150915956757 3637 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1867 st057372 64 µM -0.677496855065701 0.240818979427098 no 2595 0.249045382394566 3640 688837
SGTC_236 1509-0011 5.31 µM -0.67800534842087 0.240642961586999 no 2596 0.248884151037983 3718 3107280
SGTC_754 3474-0146 171 µM -0.679061288712551 0.240277665726342 no 2597 0.248549514617578 3593 24762078
SGTC_77 0828-0286 12.516 µM -0.681810940878554 0.239327860344387 no 2598 0.24767925259469 3630 745345
SGTC_1975 st070967 30.8 µM -0.682521186535552 0.239082855708872 no 2599 0.247454725342081 3657 261391
SGTC_2561 acetosyringone 100 µM -0.682671101692352 0.239031158865165 no 2600 0.247407347140955 3653 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_544 k015-0020 52.4 µM -0.683296003083951 0.238815733289724 no 2601 0.2472099096455 3653 3008304
SGTC_661 1304-0007 33.6 µM -0.684526078473228 0.238391993313677 no 2602 0.246821513809298 3659 3117130
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.685828070067919 0.237943928334822 no 2603 0.246410766590925 3683 4213774
SGTC_657 3534-0529 86.7 µM -0.686794074665498 0.237611787892684 no 2604 0.246106252124197 3673 1049549
SGTC_2671 danthron 100 µM -0.688489567394795 0.237029443868697 no 2605 0.245572268891 3632 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_673 1082-0474 110 µM -0.688954634423804 0.236869846369112 no 2606 0.245425908217834 3679 3098046
SGTC_2290 7904846 200 µM -0.691093824583487 0.236136499880895 no 2607 0.244753290423771 3704 2962154
SGTC_1765 st044815 90.4 µM -0.692287832980859 0.235727720378398 no 2608 0.244378294685458 3653 645695
SGTC_2187 6125751 200 µM -0.692666516527996 0.235598156217836 no 2609 0.244259428302114 3659 874498
SGTC_704 1310-0270 142 µM -0.694475565634717 0.234979744020741 no 2610 0.243692009515216 3642 5718033
SGTC_878 0828-0289 13.7 µM -0.695654042034852 0.234577372112053 no 2611 0.243322756682488 3674 745350 YLR208W SEC13
SGTC_2762 leflunomide 42.06 µM -0.696143246099423 0.234410453213298 no 2612 0.243169562893807 3656 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1352 1496-0991 99 µM -0.696525746978525 0.234279987777589 no 2613 0.243049819442348 3659 3000039
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.697146066048088 0.234068491521 no 2614 0.242855693857882 3689 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1243 0416-0003 5.65 µM -0.700537687897513 0.232913998026754 no 2615 0.241795788662593 3687 2141977
SGTC_2274 7947094 46.08 µM -0.702090447371833 0.232386502800405 no 2616 0.241311379639884 3671 2971028
SGTC_2705 st078069 42.8 µM -0.70267975056371 0.232186481930871 no 2617 0.241127674889003 3667 1530061
SGTC_1674 st016616 23.6 µM -0.703610167624631 0.231870875580924 no 2618 0.240837788822971 3675 625830
SGTC_714 4296-0578 26.1 µM -0.704848885800888 0.231451061621505 no 2619 0.24045214113912 3692 1589775
SGTC_3348 9149464 3.537 µM -0.706737864237409 0.230811684665573 no 2620 0.239864697269596 3681 1951442
SGTC_244 nsc-207895 1.295 µM -0.706807243232588 0.230788220222726 no 2621 0.239843136360653 3554 42640
SGTC_1444 4112-3581 28 µM -0.707401811940828 0.230587187727961 no 2622 0.239658405615081 3718 2877249
SGTC_2357 9067248 200 µM -0.707584949731669 0.230525285844032 no 2623 0.239601520890229 3689 9150235
SGTC_550 4123-0385 25.7 µM -0.708266606123327 0.230294962744247 no 2624 0.239389855281953 3704 5731123
SGTC_2135 5326629 150.42 µM -0.708361994146088 0.230262742601342 no 2625 0.239360243867343 3678 5020077
SGTC_3154 9100113 49.47 µM -0.714267000185621 0.228273066681138 no 2626 0.237531046882378 3708 25237525
SGTC_3233 9132340 49.47 µM -0.714709512256268 0.228124353668668 no 2627 0.237394279373191 3695 17682950
SGTC_899 1083-0020 478 µM -0.715464233145523 0.227870843798155 no 2628 0.237161117059752 3734 767123
SGTC_2701 st077767 14.721 µM -0.716029138353376 0.22768119656825 no 2629 0.236986678472429 3706 5721188
SGTC_3217 9129673 49.47 µM -0.716064800830424 0.227669227117223 no 2630 0.236975668527945 3694 17248312
SGTC_272 doxorubicin 8.13 µM -0.716169707810757 0.227634019082768 no 2631 0.236943282614387 3701 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3077 9117319 49.47 µM -0.71628956934497 0.227593795873876 no 2632 0.236906283047238 3701 17154678
SGTC_3014 9081533 49.47 µM -0.716608780383583 0.227486694356241 no 2633 0.236807762591238 3700 21367265
SGTC_2294 7971431 200 µM -0.716938250069751 0.227376180637775 no 2634 0.236706099565107 3643 5741572
SGTC_1159 4092-0538 61.2 µM -0.717635422830093 0.227142428355963 no 2635 0.236491055169738 3735 717301
SGTC_1044 1222-0021 1.78 µM -0.71951292518193 0.226513602142419 no 2636 0.235912470665757 3719 4306703
SGTC_1419 3993-2473 62.6 µM -0.719581069595453 0.226490797238249 no 2637 0.235891485480863 3765 704026
SGTC_3092 9117248 49.47 µM -0.720748244070873 0.226100397167007 no 2638 0.235532211957555 3763 17141857
SGTC_212 3807-4682 38.772 µM -0.721666496916836 0.225793524651062 no 2639 0.235249772505576 3805 3125501 YBL034C STU1
SGTC_1209 2323-2347 50.3 µM -0.722741241215737 0.225434653387933 no 2640 0.234919436518122 3680 5412760
SGTC_3268 9137683 49.47 µM -0.723603369099412 0.225147011094508 no 2641 0.234654636212787 3726 1953228
SGTC_3280 9140961 49.47 µM -0.723923809215878 0.22504015175674 no 2642 0.234556255968637 3727 4901226
SGTC_1863 st057641 20.1 µM -0.72424162254411 0.224934196785389 no 2643 0.234458704729716 3720 3921635
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.724566984392647 0.224825754530212 no 2644 0.234358859766973 3749 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3272 9137413 49.47 µM -0.725058047434302 0.224662140643207 no 2645 0.234208210050375 3674 17614870
SGTC_3248 9135562 49.47 µM -0.725186064049766 0.22461949877606 no 2646 0.23416894556099 3738 17650701
SGTC_287 k060-0039 29.6 µM -0.725435138406957 0.22453654617508 no 2647 0.23409256141155 3742 5861974
SGTC_2658 polymyxin b sulfate 77.05 µM -0.725796478077279 0.224416235243142 no 2648 0.233981773159019 3711 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1840 st055363 71 µM -0.726131943751892 0.224304572023371 no 2649 0.233878943987043 3703 676033
SGTC_965 1291-5240 308 µM -0.72654794706272 0.224166144838319 no 2650 0.233751462669576 3687 2834598
SGTC_576 1073-0113 22.7 µM -0.727386694524082 0.223887194989589 no 2651 0.233494551502482 3855 5439563
SGTC_1747 st037496 66.6 µM -0.728434525041958 0.223538985812714 no 2652 0.233173817653091 3748 723305
SGTC_21 0849-0113 22.993 µM -0.72861487330813 0.223479084572299 no 2653 0.233118638945814 3686 1560156
SGTC_2440 5628896 157.78 µM -0.731339794812241 0.22257513556437 no 2654 0.23228581458464 3765 5522048
SGTC_171 k064-0041 9.68 µM -0.731579607317711 0.222495681540017 no 2655 0.232212599446165 3709 53325
SGTC_2192 5915882 198.485 µM -0.73165467036219 0.222470815181152 no 2656 0.23218968521877 3691 2876149
SGTC_1907 st060210 83.7 µM -0.732518231166699 0.222184854836579 no 2657 0.231926159629005 3726 688793
SGTC_1786 berberine 21.6 µM -0.733069992962612 0.222002253797054 no 2658 0.23175787036984 3695 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1897 st060201 15 µM -0.734405662037475 0.221560580004725 no 2659 0.231350768496289 3773 611878
SGTC_2862 9027634 71.43 µM -0.73464095166528 0.221482827419132 no 2660 0.231279095329436 3663 5012562
SGTC_3182 9108849 49.47 µM -0.734983784785186 0.221369564498005 no 2661 0.231174684786724 3755 17133045
SGTC_1822 st052468 42 µM -0.735029214387998 0.221354558254276 no 2662 0.231160851080054 3733 2873678
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.735220173100357 0.221291487397808 no 2663 0.231102707553622 3792 688801
SGTC_2195 6536160 144.242 µM -0.735437585236539 0.221219691878403 no 2664 0.231036519367943 3658 3834386
SGTC_1937 st074714 47.2 µM -0.737093898423438 0.220673168923326 no 2665 0.230532624710737 3691 17250970
SGTC_2331 7980721 200 µM -0.73781807468814 0.220434460368835 no 2666 0.230312504103014 3715 2981221
SGTC_2507 purpurin 79.67 µM -0.738299662938303 0.220275797511233 no 2667 0.230166185638255 3743 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1431 4049-0260 9.09 µM -0.738493605363729 0.220211920224766 no 2668 0.230107275805869 3705 3854841
SGTC_2597 laccaic acid a 100 µM -0.738499340086711 0.220210031586009 no 2669 0.230105534017483 3738 5491415 A textile dye.
SGTC_2825 7998094 58.44 µM -0.738549853690802 0.220193396144399 no 2670 0.230090192006759 3730 2987815
SGTC_1523 st012844 44.7 µM -0.740180101322497 0.219656900348649 no 2671 0.229595359994815 3843 4274103
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.740518102640593 0.219545762010761 no 2672 0.229492840511318 3700 4620898
SGTC_1954 st077032 68.9 µM -0.740766549760157 0.219464090621809 no 2673 0.229417500152695 3646 698907
SGTC_347 4534-1311 26.2 µM -0.740947640635288 0.219404572078848 no 2674 0.229362593977321 3736 2862016
SGTC_1027 k015-0025 8.67 µM -0.742371450754563 0.218936936321436 no 2675 0.228931156015104 3720 3598955
SGTC_776 4476-4378 112 µM -0.743398292031461 0.218600037030352 no 2676 0.22862028902729 3798 2892008
SGTC_757 1066-0008 322 µM -0.744069462697995 0.218379992114232 no 2677 0.228417226312859 3794 6842497
SGTC_362 0310-0100 9.03 µM -0.747654465355419 0.217206803273131 no 2678 0.227334301641771 3819 790235
SGTC_1056 3448-1962 115 µM -0.749908621669548 0.216471000724299 no 2679 0.226654870755575 3771 715507
SGTC_1934 st074720 32.6 µM -0.750505070819909 0.216276549158241 no 2680 0.2264752854571 3718 17250992
SGTC_2812 7970281 58.44 µM -0.750692028156361 0.216215619023358 no 2681 0.226419010883009 3779 2233435
SGTC_654 1124-0271 80.9 µM -0.751061174475286 0.216095341970219 no 2682 0.22630792021211 3755 5403748
SGTC_1237 0330-0133 46.1 µM -0.751121526972912 0.216075681311647 no 2683 0.22628976069666 3698 X1237 YHR072W ERG7
SGTC_1024 4507-0395 26 µM -0.751325770567405 0.216009153830002 no 2684 0.226228311770985 3801 4201836
SGTC_571 k831-0106 44.2 µM -0.751674477182141 0.215895598391342 no 2685 0.226123421352711 3707 4783639
SGTC_2244 6635614 200 µM -0.752026757916936 0.215780914182315 no 2686 0.226017483758302 3682 836499
SGTC_349 k015-0014 24 µM -0.752294010241855 0.215693934342922 no 2687 0.225937134561725 3754 2196908
SGTC_2959 9079155 11 µM -0.753172220811719 0.215408255448487 no 2688 0.225673215024053 3757 16189457
SGTC_2118 5526350 200 µM -0.753425770930791 0.21532581731602 no 2689 0.225597050690545 3800 743594
SGTC_2019 4016004 108 µM -0.755490071327484 0.214655321661582 no 2690 0.224977493713189 3776 45595336
SGTC_2591 skatole 100 µM -0.756648280058397 0.214279661357583 no 2691 0.224630304110299 3794 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1155 4088-0394 48.2 µM -0.757107451242488 0.214130836971326 no 2692 0.224492745167258 3741 2326248
SGTC_3082 9117008 49.47 µM -0.757384014123617 0.214041227753587 no 2693 0.224409915265471 3831 41448529
SGTC_868 0527-0199 213 µM -0.757449723672846 0.214019940393202 no 2694 0.224390237967756 3733 2849450
SGTC_423 5-fluorouracil 457 µM -0.758069790057454 0.213819123481301 no 2695 0.224204601909725 3737 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2539 epi(13)torulosol 80 µM -0.759058447169711 0.213499160521399 no 2696 0.223908797263188 3791 6708597
SGTC_2560 caryophyllene 100 µM -0.759725977864896 0.213283282851184 no 2697 0.223709198619793 3826 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_633 0437-0093 97.7 µM -0.760445265380219 0.21305080968427 no 2698 0.223494237420893 3743 2831118
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.76158554869318 0.212682574094672 no 2699 0.22315370128369 3793 364106
SGTC_1676 st018489 23.4 µM -0.762264562144539 0.212463474611082 no 2700 0.222951059967354 3824 3696235
SGTC_1640 st009078 66.4 µM -0.76352437969476 0.212057314646588 no 2701 0.222575364217346 3759 690618
SGTC_3310 9130229 44.1445 µM -0.764107165695368 0.211869580556966 no 2702 0.222401691212838 3847 7761258
SGTC_2975 9084847 53.72 µM -0.765681860031954 0.211362807494875 no 2703 0.221932811585941 3846 27211724
SGTC_1364 1653-0028 37.6 µM -0.76678947752584 0.211006776290132 no 2704 0.221603346798622 3783 5718652
SGTC_3223 9129970 49.47 µM -0.767036249195109 0.210927502224139 no 2705 0.221529981776153 3833 17248386
SGTC_1461 k072-0203 53.8 µM -0.768291286821447 0.21052459849678 no 2706 0.221157075006255 3718 5418714
SGTC_375 3970-0961 9.27 µM -0.768775345560229 0.210369322284332 no 2707 0.22101334364733 3761 2898222
SGTC_2913 7966556 36.57 µM -0.771820430514548 0.209394063893119 no 2708 0.2201103947399 3680 2976516
SGTC_2285 7945142 200 µM -0.773666726166298 0.208804043109796 no 2709 0.219563950838903 3826 2970608
SGTC_2528 xanthyletin 44.79 µM -0.773808955899347 0.208758631424207 no 2710 0.219521887778441 3857 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.77481830891799 0.208436528351208 no 2711 0.219223514451291 3753 97141
SGTC_795 0685-0265 78 µM -0.775118592262317 0.208340759023654 no 2712 0.219134793157518 3838 302754
SGTC_1522 st012842 45.6 µM -0.777167853984052 0.207687881569899 no 2713 0.21852987261341 3701 3491067 YOR116C RPO31
SGTC_1511 0906-3109 28.5 µM -0.777801477888928 0.20748625925007 no 2714 0.21834302828052 3841 2882180
SGTC_2381 9035592 200 µM -0.778717774166391 0.207194893865011 no 2715 0.218072991765779 3827 4749657
SGTC_1479 0549-0158 134 µM -0.780186763134201 0.206728287655333 no 2716 0.217640476259628 3841 5440202
SGTC_376 3970-0862 59.1 µM -0.781182860378253 0.20641224394176 no 2717 0.217347476452601 3816 3135186
SGTC_1518 st038567 90.8 µM -0.781284890190158 0.206379887891998 no 2718 0.217317477474228 3788 77966
SGTC_288 1315-0019 35.1 µM -0.781740059240718 0.206235579710559 no 2719 0.217183677028498 3872 6811474
SGTC_311 1315-0136 58 µM -0.783225283305197 0.205765115941795 no 2720 0.216747415111186 3858 6759207
SGTC_2400 5203494 178.7 µM -0.783541878735979 0.205664912687364 no 2721 0.216654485599875 3745 6777674
SGTC_1781 st038725 66.3 µM -0.783584914195976 0.205651294091884 no 2722 0.216641855282111 3812 4270275 YIL048W NEO1
SGTC_8 0354-0001 70 µM -0.784201568644559 0.20545621223714 no 2723 0.216460922431774 3819 4993152
SGTC_2326 6164455 177.58 µM -0.78678967726107 0.204638649836672 no 2724 0.215702498658483 3818 2888790
SGTC_944 3370-0224 231 µM -0.787431432269748 0.204436224535795 no 2725 0.215514676307973 3855 4580514
SGTC_688 0527-0193 473 µM -0.788114903339533 0.204220772074017 no 2726 0.215314749266743 3828 4007154
SGTC_2389 9091542 195.52 µM -0.791252197526034 0.203233530438046 no 2727 0.214398418644486 3827 3626624 YOL127W RPL25
SGTC_2629 bisabolol 100 µM -0.791747123914824 0.203078047874101 no 2728 0.214254069547766 3831 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2807 7945238 51.95 µM -0.791889157150642 0.203033440838913 no 2729 0.214212654902531 3866 17148797
SGTC_61 0978-8327 98.565 µM -0.792917442175388 0.20271067163111 no 2730 0.213912962200008 3789 6150059 YHR072W ERG7
SGTC_364 0083-0097 67.7 µM -0.794818554994194 0.202114737901482 no 2731 0.213359527981132 3912 5207356
SGTC_1945 st075991 56.6 µM -0.794993175111209 0.202060053094661 no 2732 0.213308736093291 3833 1084980
SGTC_2314 7727897 200 µM -0.795323567593176 0.201956610155083 no 2733 0.213212653868375 3846 900724
SGTC_1689 st020265 53.493 µM -0.79542311803032 0.201925448016716 no 2734 0.213183708317443 3799 5758320 YPR016C TIF6
SGTC_2984 9022109 38.96 µM -0.796224507224266 0.201674695112674 no 2735 0.2129507777534 3852 6459207
SGTC_2893 9048488 25.97 µM -0.796691835286079 0.201528555330845 no 2736 0.212815013472532 3864 6467338
SGTC_2069 5228469 200 µM -0.797383687042944 0.201312320501424 no 2737 0.212614115220389 3804 2835210
SGTC_522 1273-0010 11.6 µM -0.797583292241693 0.201249960749566 no 2738 0.212556174935028 3935 5705015
SGTC_3170 9103054 49.47 µM -0.798463082328923 0.2009752387678 no 2739 0.212300904300781 3846 16432970
SGTC_1049 3226-0134 66 µM -0.798900557002492 0.200838717348482 no 2740 0.212174037978136 3863 5702385
SGTC_1742 st038235 28.8875 µM -0.798927433434366 0.200830331915321 no 2741 0.212166245340112 3875 564103 YBR002C RER2
SGTC_2822 7994718 71.43 µM -0.798931134378156 0.200829177239188 no 2742 0.212165172289821 3792 1018011
SGTC_1105 epirubicin 18.1 µM -0.799347187982626 0.200699395975535 no 2743 0.212044562087921 3829 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2940 9060638 45.86 µM -0.79940263048866 0.200682105375329 no 2744 0.212028492831612 3846 4027022
SGTC_2399 5884133 200 µM -0.799414398291664 0.200678435519599 no 2745 0.212025082185587 3847 722445
SGTC_1181 1222-0449 220 µM -0.799736222197307 0.200578088537069 no 2746 0.211931820846872 3844 658318
SGTC_3057 9095946 49.47 µM -0.803503586703385 0.199405639713059 no 2747 0.210841862254555 3832 24540043
SGTC_904 1141-0088 396 µM -0.804034755915571 0.199240666028568 no 2748 0.210688451397927 3856 1378119
SGTC_957 1187-1561 14.1 µM -0.804318810237901 0.19915247649598 no 2749 0.210606438476595 3799 1538454
SGTC_1881 5652484 16 µM -0.808765390844848 0.19777502656238 no 2750 0.209325053511751 3792 2255129
SGTC_756 0508-1999 28.3 µM -0.809955110959423 0.19740745671278 no 2751 0.208982987820195 3845 6753853
SGTC_1280 0880-0253 10.1 µM -0.810290702094776 0.197303848938098 no 2752 0.208886558967056 3830 6836607
SGTC_1631 benzylvanillin 81.9 µM -0.81079309839263 0.197148804538516 no 2753 0.20874224927589 3923 75506
SGTC_3191 9110352 49.47 µM -0.811113438930066 0.197049982823923 no 2754 0.208650264464227 3801 17122424
SGTC_630 4356-0227 183 µM -0.811140000599601 0.197041790172099 no 2755 0.208642638434416 3825 779312
SGTC_2200 6600604 21.907 µM -0.811204601432866 0.197021865623337 no 2756 0.208624091796553 3810 2904777
SGTC_1928 4'-methoxychalcone 40.3 µM -0.812913953292756 0.196495100932024 no 2757 0.208133696968245 3908 641818
SGTC_2123 5259487 200 µM -0.812960385774926 0.196480803920688 no 2758 0.208120385481773 3850 2173474
SGTC_87 0100-0052 35.5 µM -0.814156132350719 0.196112839141399 no 2759 0.207777756236454 3915 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2090 5301565 104.445 µM -0.814601395442798 0.195975926051523 no 2760 0.207650255721418 3855 2056344
SGTC_2060 5238662 140 µM -0.815684170124142 0.195643227796307 no 2761 0.207340397529582 3845 790130
SGTC_1948 st076329 66.6 µM -0.816030280477331 0.195536952725739 no 2762 0.20724140863943 3730 24208413
SGTC_3122 9126309 49.47 µM -0.81639329494952 0.195425524828203 no 2763 0.207137615141799 3891 17591206
SGTC_300 r073-0011 5.04 µM -0.816451318177815 0.195407718077274 no 2764 0.207121027927201 3851 2735780
SGTC_1732 st034308 51.822 µM -0.816501266752678 0.195392390146476 no 2765 0.207106749659044 3736 830119
SGTC_2259 7964009 200 µM -0.816815754743712 0.195295898661178 no 2766 0.207016863695522 3902 313134
SGTC_1477 0139-0234 16 µM -0.81681701333313 0.195295512557827 no 2767 0.207016504015853 3874 620880
SGTC_1362 1611-0397 101 µM -0.817916891647633 0.194958275074113 no 2768 0.206702322180417 3828 27816
SGTC_1367 1812-0510 76.9 µM -0.81923943894196 0.194553233483994 no 2769 0.206324908734221 3906 1142582 YDR527W RBA50
SGTC_908 3448-7491 47.7 µM -0.819429273512084 0.194495137057806 no 2770 0.206270769448983 3876 1203031
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.819572752319957 0.194451234223008 no 2771 0.206229856040079 3822 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_486 niguldipine 82 µM -0.819725877833877 0.194404386264165 no 2772 0.206186197151081 3879 1236 A calcium channel blocker.
SGTC_1802 st050112 57.9 µM -0.820440401970917 0.19418587215276 no 2773 0.205982545679484 3861 4662563
SGTC_3094 9117742 49.47 µM -0.8223415157313 0.19360520689843 no 2774 0.205441277402281 3800 17149698
SGTC_2607 solasodine 47.35 µM -0.822560541360218 0.193538377062329 no 2775 0.205378972670842 3888 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1901 st060216 58.6 µM -0.823000832842222 0.193404076424333 no 2776 0.205253759906969 3855 688792
SGTC_800 3448-7362 155 µM -0.823130402013132 0.193364565204506 no 2777 0.205216920878547 3940 15991913
SGTC_2109 5483026 200 µM -0.823380213211574 0.193288400915955 no 2778 0.205145905799068 3863 759335
SGTC_3052 9092717 49.47 µM -0.823852128833901 0.193144569755827 no 2779 0.205011791841444 3851 25237534
SGTC_191 3914-0123 66.505 µM -0.824667633963371 0.192896172925111 no 2780 0.204780155883174 3806 3144412
SGTC_1737 st035557 69.7 µM -0.826660783526624 0.192289896051848 no 2781 0.204214677491968 3763 5716916
SGTC_707 0865-0008 204 µM -0.827939691132224 0.19190149205654 no 2782 0.203852327648576 3867 723043
SGTC_194 1486-1323 56.904 µM -0.828932959174507 0.191600168318313 no 2783 0.203571171939438 3907 5178754
SGTC_2952 9073731 13.78 µM -0.831475185896659 0.190830264356313 no 2784 0.202852620266798 3932 16457353
SGTC_3059 1327-0034 3 µM -0.831996169566494 0.190672721053379 no 2785 0.202705553299649 3808 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2467 5474540 200 µM -0.832447874434608 0.190536192004844 no 2786 0.202578094428014 3843 5413519
SGTC_59 0330-0160 1.33 µM -0.834039526216024 0.190055589383426 no 2787 0.202129355388656 3842 4293482
SGTC_752 1896-0090 130 µM -0.835472852997671 0.189623431509084 no 2788 0.20172576279611 3860 772567
SGTC_3149 9097855 49.47 µM -0.836147320469131 0.189420284255535 no 2789 0.201536015027064 3897 25236625 YMR079W SEC14
SGTC_1175 0741-0056 27.6 µM -0.837317290450681 0.189068211208301 no 2790 0.201207121410404 3972 765927
SGTC_14 0354-0009 295 µM -0.837489605699384 0.189016391340547 no 2791 0.201158708581456 3954 1713507
SGTC_1862 st057513 3.81 µM -0.839110212782983 0.188529459008308 no 2792 0.200703732810749 3857 5393163
SGTC_2782 7736369 71.43 µM -0.839879551028478 0.188298572399657 no 2793 0.200487962092344 3944 2950836 YOL077C BRX1
SGTC_789 1309-1135 70.6 µM -0.840006821405289 0.188260394025853 no 2794 0.200452280927175 3884 3092424
SGTC_134 0269-0018 6.916 µM -0.840869502202833 0.188001734277491 no 2795 0.200210522727183 3849 4378915
SGTC_3330 9141424 71.43 µM -0.84317828272645 0.18731056679571 no 2796 0.199564371201156 3967 27261020
SGTC_232 clozapine 119 µM -0.845136053845166 0.186725711718084 no 2797 0.19901744018614 3845 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1798 st045719 60.953 µM -0.845767307176297 0.186537375417007 no 2798 0.198841283396687 3795 3980186
SGTC_1002 4049-0206 172 µM -0.846490140727445 0.186321860419018 no 2799 0.198639685817564 3922 4662749
SGTC_2432 5630864 12.22 µM -0.846606418139692 0.186287206368315 no 2800 0.198607267672695 3942 5714970
SGTC_839 0122-0028 230 µM -0.847272850610842 0.186088667155065 no 2801 0.198421527847484 3887 759448
SGTC_2922 7999257 32.47 µM -0.847650810213827 0.185976126206548 no 2802 0.198316234208625 3869 2988377
SGTC_2565 isoliquiritigenin 100 µM -0.848529769769612 0.185714571136802 no 2803 0.198071500241339 3987 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1951 sophoraflavanone G 9.2 µM -0.848724486830577 0.185656659391118 no 2804 0.198017308690897 3882 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_698 k064-0052 127 µM -0.850191847742332 0.185220604908905 no 2805 0.197609216698317 3950 5088751
SGTC_1649 st011737 51.3 µM -0.852232138705438 0.184615351269236 no 2806 0.197042631084923 3888 1761035
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.853401630047423 0.184268976064548 no 2807 0.19671830893395 3901 688669
SGTC_1661 st013063 9.66 µM -0.853599575174123 0.184210389521483 no 2808 0.196663447003068 3936 721395
SGTC_3053 9095903 49.47 µM -0.854000259300117 0.184091833063695 no 2809 0.196552422856221 3987 17174018
SGTC_3030 9087619 49.47 µM -0.856757650520528 0.183277250845045 no 2810 0.195789417458759 3949 25236973
SGTC_1683 st010134 710 nM -0.856840649662602 0.18325276632591 no 2811 0.195766478439778 3915 3818134
SGTC_406 estrone 100 µM -0.857711208224204 0.182996076857358 no 2812 0.195525974738413 3876 5870 A steroid.
SGTC_1452 4194-0072 190 µM -0.858713367862989 0.182700861948846 no 2813 0.195249336714373 3944 1343545
SGTC_3342 9147791 14.508 µM -0.859307023445037 0.182526123968286 no 2814 0.195085575144486 3836 1838168
SGTC_1825 st052143 62.6 µM -0.859565124214834 0.182450186547585 no 2815 0.195014403365816 3925 674173
SGTC_806 3966-4455 5.86 µM -0.863309880701484 0.181350639952192 no 2816 0.193983556543512 3906 714982
SGTC_1116 jasmonic acid 1.58368 µM -0.864155355501722 0.181102964426666 no 2817 0.193751276714407 3986 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1857 st056007 79.3 µM -0.864500458538737 0.181001929999783 no 2818 0.193656514274185 3919 619834
SGTC_3187 9109394 49.47 µM -0.865516030845811 0.180704809935125 no 2819 0.193377810519596 3934 17098090
SGTC_977 1348-1378 135 µM -0.866580739596649 0.180393642864235 no 2820 0.193085885169401 3916 X977
SGTC_1003 4049-0218 100 µM -0.866622103510025 0.180381560817573 no 2821 0.193074549307749 3959 295161
SGTC_2715 st079500 56.4 µM -0.866738128212506 0.180347673699986 no 2822 0.193042754678757 3866 28246688
SGTC_2343 7990716 14.84 µM -0.868442478602464 0.179850347665809 no 2823 0.19257607445205 3917 6456862
SGTC_2666 tannic acid 100 µM -0.87027738328242 0.179315890064458 no 2824 0.192074417812161 3937 16134267 A thiamine antagonist.
SGTC_178 4092-0806 87.505 µM -0.871889780245005 0.178847068174512 no 2825 0.191634254736428 3858 2169044
SGTC_29 0299-0004 12.984 µM -0.872797285848 0.178583540718257 no 2826 0.191386789632216 3817 16871 A napthoquinone isolated from Swertia calycina.
SGTC_146 3448-8650 53.125 µM -0.873413150459416 0.178404841258709 no 2827 0.19121896287257 3909 2891488 YIL048W NEO1
SGTC_482 fipronil 114 µM -0.873847890521017 0.17827876480748 no 2828 0.191100547965989 3996 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2512 diallyl trisulfide 49.23 µM -0.874680088458119 0.1780375805509 no 2829 0.190873998567497 3956 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1377 2944-0135 198 µM -0.874734059802725 0.178021945899865 no 2830 0.190859311630129 3992 1894137
SGTC_380 3970-0968 6 µM -0.874987997912634 0.177948395636147 no 2831 0.190790218097515 3840 2891601
SGTC_3208 9114115 49.47 µM -0.878798197711481 0.176847116611542 no 2832 0.189755351835485 3981 650895
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.879070221660778 0.176768657415679 no 2833 0.189681601252142 3942 2724 A muscle relaxant with antifungal properties.
SGTC_1210 3013-0140 750 nM -0.879942363160945 0.176517256197349 no 2834 0.189445266915776 3981 905973
SGTC_2411 st077133 39.94 µM -0.881696615364768 0.176012265364415 no 2835 0.188970445910447 4053 1403142 YNL221C POP1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.881791481284735 0.175984982718566 no 2836 0.18894478959624 3887 6708514
SGTC_1467 k284-1082 293 µM -0.882357271021118 0.175822321931717 no 2837 0.188791817369552 3896 3334705
SGTC_1860 st056228 74.6 µM -0.882423942603165 0.175803160569172 no 2838 0.188773796442779 3938 688679
SGTC_149 3970-0822 46.1 µM -0.883552306176605 0.175479070375141 no 2839 0.188468967389568 3959 3114250 YBL034C STU1
SGTC_256 clotrimazole 625 nM -0.88497937000154 0.175069729784433 no 2840 0.188083879052378 3884 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1112 tnp00069 1.16933 µM -0.887870006237177 0.174242434375577 no 2841 0.187305340169465 3965 145826
SGTC_816 0325-0417 81.3 µM -0.888317539185958 0.174114573614301 no 2842 0.187184983888258 3989 68101
SGTC_407 eburnamonine 100 µM -0.889129761376944 0.173882673031735 no 2843 0.186966672913796 3811 3195
SGTC_2801 7907800 81.82 µM -0.891037260529939 0.173338828573025 no 2844 0.18645459057699 3998 6620925
SGTC_909 3448-9333 149 µM -0.892967846193865 0.172789505861411 no 2845 0.18593719597014 3881 3344074
SGTC_489 paxilline 115 µM -0.893427530002552 0.17265887261749 no 2846 0.185814132616783 3945 105008 A toxic potassium channel blocker.
SGTC_711 k292-0785 179 µM -0.897763044927441 0.171429901904587 no 2847 0.184655945168322 3935 4146315
SGTC_273 hydroxyurea 18.1 mM -0.898265513789999 0.17128783152257 no 2848 0.184522006725196 4038 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_832 4083-0019 164 µM -0.899416331630421 0.170962727656753 no 2849 0.184215471680179 4027 1990758
SGTC_3350 9150499 3.57 µM -0.900302229572334 0.170712732248124 no 2850 0.183979717452938 3941 4910996 YPR165W RHO1
SGTC_2727 riluzole 51.77 µM -0.902360407463565 0.170132829848293 no 2851 0.183432722972175 3984 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1190 1486-1332 13 µM -0.904357137129786 0.169571448679243 no 2852 0.182903029304036 3976 4150046
SGTC_2811 7967822 32.47 µM -0.904712020339003 0.16947179767393 no 2853 0.182808985675214 4050 2232244
SGTC_2961 9083290 32.55 µM -0.904995485328519 0.169392227865665 no 2854 0.182733889477267 3911 17741490
SGTC_912 3474-0017 2.18 µM -0.906349527042419 0.16901247357163 no 2855 0.182375439409364 4039 3360550
SGTC_3198 9112019 49.47 µM -0.90723104671485 0.168765536832463 no 2856 0.182142314484654 4029 45595555
SGTC_1899 st063254 59.6 µM -0.907958747939787 0.168561863450248 no 2857 0.181950008500159 3918 3093813
SGTC_215 1287-0124 461.5 µM -0.908490092860138 0.168413247304468 no 2858 0.18180967285149 3989 5560863
SGTC_2966 9084041 48.03 µM -0.910229086879345 0.167927443410506 no 2859 0.181350853717744 3896 17741380
SGTC_995 3931-2021 34.6 µM -0.913134173668307 0.167117895112899 no 2860 0.180585989553873 3988 730143
SGTC_2833 9001315 45.46 µM -0.915977668789199 0.166327951276221 no 2861 0.179839303817216 3974 2989378
SGTC_3252 9135871 49.47 µM -0.91671087280622 0.166124653489613 no 2862 0.179647083529424 4003 17682838
SGTC_3288 9119690 36.221 µM -0.918509559126659 0.165626606329978 no 2863 0.179176078370667 3994 17595618 YKL019W RAM2
SGTC_2534 helenine 20.12 µM -0.91861573111058 0.165597238055294 no 2864 0.179148300405977 3984 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3281 9140613 49.47 µM -0.918764690649522 0.165556039975439 no 2865 0.179109332424031 4014 16013766
SGTC_3356 9151811 4.48 µM -0.918768253215156 0.1655550547497 no 2866 0.179108400518172 3984 1859254 YPR165W RHO1
SGTC_106 0092-0003 11.579 µM -0.923103997135026 0.164358817844366 no 2867 0.177976505904675 3896 1072148
SGTC_3196 9111891 49.47 µM -0.923204032370237 0.164331284305207 no 2868 0.177950443931764 3983 18891510
SGTC_551 k048-0028 34.9 µM -0.923287578993784 0.164308291357205 no 2869 0.177928679547166 4013 6836383
SGTC_1519 esterone 74 µM -0.924617289864737 0.16394262114521 no 2870 0.177582508083238 3971 698 A steroid.
SGTC_727 3032-0951 202 µM -0.926174983801838 0.163514927773299 no 2871 0.177177525440661 4009 3652836
SGTC_203 k066-0004 30.888 µM -0.92922380728598 0.162679916495173 no 2872 0.176386555962326 4069 6795412
SGTC_416 estradiol valerate 100 µM -0.92979435507828 0.162523963606283 no 2873 0.176238784805802 4030 13791 A steroid.
SGTC_3311 9131146 2.8755 µM -0.930290464061424 0.162388436834688 no 2874 0.176110356906712 3986 4900406 YPR165W RHO1
SGTC_1067 clotrimazole 1.36 µM -0.93416636112726 0.161332154472188 no 2875 0.175109042428464 4024 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_322 k048-0136 19.3 µM -0.934853261221083 0.161145424922869 no 2876 0.174931963416451 4081 6823282
SGTC_3258 9138477 49.47 µM -0.935576501589183 0.160948968959174 no 2877 0.174745638939588 4040 4970355
SGTC_262 fenpropimorph 62.5 µM -0.936147019006367 0.160794107936537 no 2878 0.17459874856662 3981 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1412 3909-8563 178 µM -0.937726402303879 0.160365908384813 no 2879 0.174192515932475 4089 23767530
SGTC_2273 7815444 169.05 µM -0.939282686572731 0.159944700970561 no 2880 0.173792812663236 3981 2824616
SGTC_1225 1216-0074 20.6 µM -0.941002570455824 0.159480057827236 no 2881 0.173351770963057 4040 4241466
SGTC_2047 4141938 200 µM -0.941326195630655 0.159392726253222 no 2882 0.173268861247893 4016 3807862
SGTC_3099 9120367 49.47 µM -0.942954157603779 0.15895388907809 no 2883 0.172852175812129 4034 24824940
SGTC_976 1348-1067 47.6 µM -0.945270031283091 0.15833098237649 no 2884 0.172260517132654 4045 5310671 YGL099W LSG1
SGTC_928 2764-0428 58.7 µM -0.946985572395091 0.157870582739357 no 2885 0.17182306540091 4063 662578
SGTC_348 k064-0012 10.7 µM -0.949981989339864 0.157068545451257 no 2886 0.171060702118948 3932 5066323
SGTC_2222 6885208 172.143 µM -0.951904244361508 0.156555437749546 no 2887 0.170572773407246 3968 609514
SGTC_724 3910-0327 137 µM -0.957689586445874 0.155017821985395 no 2888 0.169109654696681 4095 2885483
SGTC_2122 5258151 111.688 µM -0.958332554664243 0.154847553121631 no 2889 0.168947546473643 4033 2173356
SGTC_2272 7805186 180 µM -0.961165377676067 0.154098845366815 no 2890 0.168234510819125 4059 2956062 YPR165W RHO1
SGTC_1653 st012112 65 µM -0.96164768295514 0.15397161230962 no 2891 0.168113305315696 4043 720429
SGTC_836 0330-0104 1.35 µM -0.962722652851222 0.153688283376441 no 2892 0.167843362740726 4040 46494820
SGTC_427 1354-0053 47.3 µM -0.964086138286047 0.153329407515359 no 2893 0.167501370870141 4141 6813657
SGTC_2797 7859098 81.82 µM -0.964953858151231 0.15310130883407 no 2894 0.167283961738487 4041 972681
SGTC_1824 st053723 68.6 µM -0.965356836360984 0.152995453931463 no 2895 0.167183056531186 4082 675225
SGTC_76 0433-0009 400.328 µM -0.967836837916947 0.15234507184537 no 2896 0.166562931454837 4143 2841569
SGTC_34 0469-0683 81.75 µM -0.968253521967412 0.152235976512244 no 2897 0.166458885362864 4017 3690923
SGTC_2071 5230951 39.92 µM -0.973041256573527 0.150986184397344 no 2898 0.165266398900269 4086 1799272
SGTC_2546 rhodinyl acetate 100 µM -0.973375189001052 0.150899270014556 no 2899 0.165183432724506 4002 6708682
SGTC_2721 ifenprodil 61.44 µM -0.974750180141002 0.150541744634771 no 2900 0.164842097529024 4039 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_202 3594-0513 34.79 µM -0.975142211109559 0.150439912143026 no 2901 0.164744861407564 4068 708429
SGTC_313 3474-0040 5.03 µM -0.978004530044854 0.149697797880976 no 2902 0.164036041795184 4057 1043375 YIL048W NEO1
SGTC_681 1642-0006 26.6 µM -0.980354278135998 0.149090406516261 no 2903 0.163455635300621 4086 4446530
SGTC_1017 4239-0030 168 µM -0.981295195705621 0.148847648934558 no 2904 0.163223595613976 4091 1149593
SGTC_2373 9071805 200 µM -0.98226560710084 0.148597558758112 no 2905 0.162984506776579 4070 10149009
SGTC_2436 5633522 8.09 µM -0.983438607468524 0.14829563346953 no 2906 0.162695808391016 4062 5724242
SGTC_1615 st002656 86.5 µM -0.983792062104959 0.14820473626993 no 2907 0.162608881532931 4066 1584458
SGTC_2761 levamisole 97.89 µM -0.986660595793961 0.14746842044052 no 2908 0.161904526691321 4038 26879 An alkaline phosphatase inhibitor.
SGTC_2837 9008476 45.46 µM -0.987120843394727 0.147350509352938 no 2909 0.161791700395875 4108 2992805
SGTC_3015 9080845 49.47 µM -0.987866307358762 0.147159662605006 no 2910 0.16160906414391 4126 5296973
SGTC_1374 2889-5571 141 µM -0.989488131584119 0.146745030918438 no 2911 0.161212186908603 4131 2853281
SGTC_2495 cafestol 54.53 µM -0.990391097402848 0.146514520853295 no 2912 0.160991497583081 4094 16667697 An anti-infammatory.
SGTC_2816 7982706 58.44 µM -0.990743305301843 0.146424674774771 no 2913 0.16090546970565 4111 2981853
SGTC_1792 st045773 43.6 µM -0.991306008163871 0.146281209487013 no 2914 0.160768090057986 4027 2919270
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.991789466412622 0.146158023617814 no 2915 0.160650118570002 4131 61125 An anti-inflammatory.
SGTC_2434 5670830 169.91 µM -0.9923753740909 0.146008826900295 no 2916 0.160507223593004 4123 1549830
SGTC_2689 tacrolimus 100 µM -0.994542107963723 0.145457974534162 no 2917 0.159979507986715 4104 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.996887117630199 0.144863375746698 no 2918 0.15940965268452 4101 7104
SGTC_3138 9097216 49.47 µM -0.998331226594411 0.144498023996069 no 2919 0.159059385161912 4053 25237486
SGTC_883 0850-0245 24.6 µM -0.998721698006147 0.144399343567526 no 2920 0.158964763287866 4155 6823229 YPR165W RHO1
SGTC_207 4185-0010 4.486 µM -1.00017885938372 0.14403148895514 no 2921 0.158611979067196 4144 3761753
SGTC_1646 st011709 75.6 µM -1.00157163319926 0.143680479922079 no 2922 0.158275263545015 4016 5757843
SGTC_2228 7354201 200 µM -1.00230915645991 0.143494842127651 no 2923 0.158097150787831 4121 753451
SGTC_338 4055-0136 114 µM -1.00365413021431 0.143156723452006 no 2924 0.157772676869751 4045 2900563
SGTC_693 4161-2696 114 µM -1.00386066361989 0.143104849846161 no 2925 0.157722889607134 4124 805759
SGTC_2162 5663267 200 µM -1.00889291185641 0.14184485749053 no 2926 0.156512997472615 4082 6456493
SGTC_3123 9126162 49.47 µM -1.00956715383799 0.141676610827845 no 2927 0.156351356459625 4162 25239884
SGTC_2256 7954252 200 µM -1.01072957237829 0.141386864793829 no 2928 0.156072939548014 4119 2972920
SGTC_2418 pentamidine 31.67 µM -1.01396234754984 0.140583171575977 no 2929 0.155300359566116 4064 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3285 9112818 20.8695 µM -1.01437978674065 0.140479619436745 no 2930 0.155200782799227 4075 17017947 YPR165W RHO1
SGTC_1294 1000-1494 117 µM -1.01523515329321 0.140267594558582 no 2931 0.154996873667761 4108 712797 YDL207W GLE1
SGTC_3141 9094609 49.47 µM -1.01653860071541 0.139944919302021 no 2932 0.154686487789394 4058 25236309 YDL196W YDL196W
SGTC_1873 rapamycin 2 nM -1.01900152949665 0.139336586406291 no 2933 0.15410112020143 4065 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3298 9116858 71.43 µM -1.02053216734137 0.138959433196423 no 2934 0.153738070741727 4173 2506942
SGTC_2029 5175081 200 µM -1.02213344932355 0.138565617631115 no 2935 0.153358871813114 4079 1380876
SGTC_263 alizarin 107.927 µM -1.02239999662905 0.138500137505335 no 2936 0.153295811061386 4133 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2610 ononetin 44.17 µM -1.02371944803609 0.138176311056823 no 2937 0.152983903395631 4114 259632
SGTC_2700 st077718 96.8 µM -1.02372172147862 0.138175753542923 no 2938 0.152983366335512 4107 904970
SGTC_2627 acetyl isogambogic acid 100 µM -1.02693576252227 0.137389111153842 no 2939 0.152225356553357 4158 6857789 A caspase activator and apoptosis inducer.
SGTC_527 4476-4215 268 µM -1.02733198629304 0.137292346818508 no 2940 0.15213208281448 4105 4418754
SGTC_277 nystatin 15.5 µM -1.02817404411717 0.137086857102557 no 2941 0.151933982800366 4118 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1782 st039423 80.636 µM -1.02838892454446 0.137034452903859 no 2942 0.151883458127798 4153 2068169
SGTC_906 1165-0455 526 µM -1.02905747117374 0.136871497914777 no 2943 0.151726334661601 4096 3252859
SGTC_1821 st053465 65.6 µM -1.03004718980461 0.136630502068501 no 2944 0.151493926960866 4132 675086
SGTC_592 k241-0073 46.5 µM -1.03055487731138 0.136506993149286 no 2945 0.151374802662539 4151 4230158
SGTC_1174 0739-0097 51.1 µM -1.03160338759848 0.136252156013092 no 2946 0.151128976398535 4154 728447
SGTC_1680 diphenhydramine 100 µM -1.03494591395262 0.135441939441916 no 2947 0.150347085324108 4120 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2795 7780010 54.55 µM -1.0351704143662 0.135387639911027 no 2948 0.15029466647121 4113 953673
SGTC_2051 5263410 176 µM -1.03552224306199 0.135302573722413 no 2949 0.150212542097196 4128 227584
SGTC_2690 usnic acid 100 µM -1.03558580449584 0.135287209558105 no 2950 0.150197708683781 4169 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2333 9017922 200 µM -1.03630734617373 0.135112881277111 no 2951 0.150029390025705 4168 3163164
SGTC_1570 verbenone 133 µM -1.03708573507687 0.134924991194569 no 2952 0.149847951320409 4153 29025 A natural terpanoid with antifungal properties.
SGTC_1152 3909-8331 15.9 µM -1.03746163825009 0.134834318652469 no 2953 0.149760382525769 4083 16001939
SGTC_1137 ixabepilone 100 µM -1.03785791985588 0.134738775853333 no 2954 0.149668103429212 4086 154225 A novel microtubule stabilizer.
SGTC_1710 st031758 61.5 µM -1.03804915508466 0.134692685998033 no 2955 0.149623585503702 4163 5394341
SGTC_270 tamoxifen 5.46 µM -1.03978074745207 0.134275845146979 no 2956 0.149220887847973 4186 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_709 3807-1509 243 µM -1.04090004081015 0.134006873043213 no 2957 0.148960971396692 4194 1886677 YPL242C IQG1
SGTC_2084 5306078 60.6385 µM -1.04541856986318 0.132924811955708 no 2958 0.147914778895999 4059 679340
SGTC_2844 9010103 25.97 µM -1.04601491593945 0.132782454406171 no 2959 0.14777707290968 4160 2480525
SGTC_1124 fisetin 1.16336 µM -1.04779691181115 0.132357688669293 no 2960 0.147366092817991 4165 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_9 0092-0002 10.449 µM -1.04955884389516 0.131938627107421 no 2961 0.146960493774155 4119 759368
SGTC_1766 st045414 44.774 µM -1.04984704103878 0.131870168887924 no 2962 0.146894221733024 4160 253960
SGTC_3206 9114350 49.47 µM -1.050012948275 0.131830770472792 no 2963 0.146856079818955 4041 17087243
SGTC_497 capsazepine 133 µM -1.05090306938828 0.131619529801918 no 2964 0.146651555274134 4096 2733484 A calcium channel blocker.
SGTC_2104 5389443 200 µM -1.05147064335412 0.131484957009759 no 2965 0.146521242744181 4188 2244536
SGTC_3189 9110682 49.47 µM -1.05464855195229 0.130733224180075 no 2966 0.145793044852559 4221 17122418
SGTC_1331 1472-0049 76.2 µM -1.05671140980416 0.130246849252975 no 2967 0.145321658055029 4085 24051409
SGTC_1228 0124-0032 52.5 µM -1.05694774308011 0.130191207282556 no 2968 0.145267718714841 4218 X1228
SGTC_667 1498-1044 59 µM -1.05780506552159 0.129989498574357 no 2969 0.145072161473238 4163 6739982
SGTC_340 k038-0059 454 µM -1.05781872293521 0.129986287043258 no 2970 0.145069047619941 4128 23733424
SGTC_2202 7226349 200 µM -1.05947874211796 0.1295963437045 no 2971 0.144690902760449 4107 844334
SGTC_1693 xanthone 101.9 µM -1.05983015264451 0.129513900381652 no 2972 0.144610938257359 4191 7020 An insecticide.
SGTC_837 0091-0265 12.5 µM -1.06079098252069 0.129288668616063 no 2973 0.144392450586403 4105 759367
SGTC_1842 st055362 61.2 µM -1.06240496739968 0.128910939631577 no 2974 0.144025939844439 4132 676032
SGTC_1852 st056254 31.4 µM -1.06358046539545 0.128636314122679 no 2975 0.143759397831109 4094 442583
SGTC_3120 9124077 49.47 µM -1.06423960161949 0.128482501310223 no 2976 0.143610085631107 4278 18774327 YGL155W CDC43
SGTC_2157 5649910 96.377 µM -1.06569316304748 0.128143756615708 no 2977 0.143281184641484 4154 2858091
SGTC_2725 haloperidol 53.21 µM -1.06739925267021 0.127746953508568 no 2978 0.142895792896179 4088 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1418 3966-3099 2.4 µM -1.0684345125704 0.127506589046256 no 2979 0.142662277964 4164 740335
SGTC_744 1594-0068 283 µM -1.06989691511005 0.127167587670572 no 2980 0.14233285591411 4134 668392
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.070205012027 0.127096247386269 no 2981 0.142263519423063 4211 91467 include heat shock
SGTC_401 neomycin 50 µM -1.07055650224944 0.12701489333506 no 2982 0.142184445284191 4124 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3026 9090633 49.47 µM -1.07083542423394 0.126950361337274 no 2983 0.142121717864878 4165 25236842
SGTC_1581 himbacine 57.9 µM -1.07110138137028 0.126888850173075 no 2984 0.142061923587429 4157 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1465 k213-0056 144 µM -1.07160361240335 0.126772749640924 no 2985 0.14194905506521 4036 24048857 YMR208W ERG12
SGTC_3113 9123498 49.47 µM -1.07966238386272 0.124919917544855 no 2986 0.140146275207911 4268 8897275
SGTC_2992 9074591 71.4286 µM -1.08241426766357 0.124291573083678 no 2987 0.139534245659075 4135 17741321
SGTC_1197 1601-0112 267 µM -1.08273283068468 0.124218977812182 no 2988 0.139463513591205 4135 7350313
SGTC_1864 st057645 30.4 µM -1.08309215325753 0.124137129710638 no 2989 0.139383760759224 4214 688666
SGTC_114 0364-0001 490.298 µM -1.08388453572027 0.123956770653844 no 2990 0.139207998521838 4226 4003655
SGTC_1667 st014849 34.6 µM -1.08430859310027 0.123860323709433 no 2991 0.139113998260366 4222 5348460
SGTC_2258 7960471 200 µM -1.08469769518296 0.123771873164715 no 2992 0.139027784511407 4219 2974708
SGTC_3315 9136395 68.55 µM -1.08766973533133 0.123097728789449 no 2993 0.138370466513845 4184 16876844
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.08821188789391 0.12297503105447 no 2994 0.138250788932235 4216 279621
SGTC_1485 3909-9022 254 µM -1.08845644311342 0.122919712395287 no 2995 0.138196827640522 4218 714516
SGTC_246 cycloheximide 667 µM -1.09090960801232 0.122365769035086 no 2996 0.137656329481478 4065 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_3307 9126885 69.2785 µM -1.09306477806928 0.121880562951154 no 2997 0.137182679600364 4152 24824909
SGTC_1735 st034310 56.75 µM -1.09363933651532 0.121751437728732 no 2998 0.137056594896403 4248 871153
SGTC_213 1246-0773 967 nM -1.09530949289455 0.12137663572239 no 2999 0.136690535022889 4196 6251622
SGTC_1780 st038448 24.544 µM -1.09548229320244 0.121337903735881 no 3000 0.136652699363655 4236 728868 YDL195W SEC31
SGTC_2001 4023502 57.655 µM -1.09596671017831 0.121229371374869 no 3001 0.136546671552068 4230 108941 YCR052W RSC6
SGTC_1391 3442-0225 151 µM -1.09697681733796 0.121003279157386 no 3002 0.136325763179031 4160 5227075
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.09742674342553 0.120902667793386 no 3003 0.136227444019736 4168 6312947
SGTC_2095 5432005 200 µM -1.10026484290097 0.12026937580316 no 3004 0.135608372747987 4194 783734
SGTC_931 2812-0076 566 µM -1.1021809339829 0.11984314396156 no 3005 0.135191509565146 4146 3450959
SGTC_2445 5742597 35.57 µM -1.10379837225964 0.119484176877947 no 3006 0.134840305558923 4183 1774255
SGTC_1023 4482-3888 16 µM -1.10477480862894 0.119267838469404 no 3007 0.134628589374549 4210 3303168
SGTC_250 brefeldin a 552.239 µM -1.10546109848606 0.119115950206045 no 3008 0.134479920918984 4070 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_247 mechlorethamine 29.705 µM -1.10586317870092 0.119027026102369 no 3009 0.134392872135248 4100 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3156 9099931 49.47 µM -1.10602044833778 0.118992257088233 no 3010 0.13435883440631 4229 18111053
SGTC_1384 3089-0840 101 µM -1.1075951724493 0.118644514033646 no 3011 0.134018344631879 4183 1069836
SGTC_2582 agaric acid 100 µM -1.10916451287232 0.11829867482573 no 3012 0.133679609239283 3895 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1266 0828-0227 32.9 µM -1.10932311036068 0.118263764021888 no 3013 0.133645409431522 4195 3913820
SGTC_3005 9076496 71.4286 µM -1.11009890626255 0.11809309920503 no 3014 0.133478204251002 4168 21368410
SGTC_900 1112-0045 141 µM -1.11049010130652 0.118007107573093 no 3015 0.13339394563804 4078 56211 YIL048W NEO1
SGTC_1774 st048371 48.465 µM -1.11160440773643 0.11776240599551 no 3016 0.133154138278503 4185 4242727
SGTC_172 1112-0046 2.638 µM -1.11197481771057 0.117681143581424 no 3017 0.133074488932369 4189 2802135 YIL048W NEO1
SGTC_1318 1280-3875 124 µM -1.11317355291012 0.117418431074577 no 3018 0.132816949433585 4201 373245
SGTC_66 0109-0187 42.4 µM -1.11721682863677 0.116535378161244 no 3019 0.131950813432079 4093 759417
SGTC_2026 5148700 152 µM -1.11905528971344 0.116135419172763 no 3020 0.13155827615432 4188 79838
SGTC_2655 perillic acid 100 µM -1.11939677199408 0.116061236787016 no 3021 0.131485453739422 4225 5702197 An apoptosis inducer.
SGTC_2361 9034121 116 µM -1.12159888012196 0.115583666483199 no 3022 0.131016514010794 4226 6496917
SGTC_1865 st057639 52.2 µM -1.12262622682858 0.115361344449033 no 3023 0.130798135917927 4199 688818
SGTC_1108 betulinic acid 729.144 nM -1.12288784597458 0.115304777579353 no 3024 0.13074256502303 4202 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3023 9089636 49.47 µM -1.12296961611623 0.115287101415987 no 3025 0.130725199459116 4287 17249241
SGTC_835 0312-0010 67.2 µM -1.12546169394579 0.114749315244607 no 3026 0.130196720375971 4209 1626196
SGTC_425 3825-7017 13.1 µM -1.12581756248514 0.114672665295336 no 3027 0.130121374395936 4262 3397440
SGTC_382 3229-0966 23.2 µM -1.12714969804462 0.114386062247726 no 3028 0.129839596989785 4255 5722370
SGTC_94 0334-0113 514.748 µM -1.12862126072294 0.114070055330478 no 3029 0.129528818991419 4237 6795178
SGTC_2733 amorolfine 100 µM -1.13010004337803 0.1137531249544 no 3030 0.129217035737116 4350 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2972 9093619 59.92 µM -1.13029668967505 0.113711027354378 no 3031 0.129175614490115 4176 25236256
SGTC_2904 7225135 42.03 µM -1.13647210523945 0.112394654288645 no 3032 0.127879516764201 4320 4446116
SGTC_145 3737-0113 38.366 µM -1.13673504794942 0.112338847182819 no 3033 0.127824531578499 4180 6849351
SGTC_974 1326-0144 138 µM -1.13815877942512 0.11203701747219 no 3034 0.127527093740681 4260 5411856
SGTC_3159 9100096 49.47 µM -1.13916486796627 0.111824077562141 no 3035 0.127317197888692 4162 25236875
SGTC_1259 0671-0132 43 µM -1.14431674372475 0.110738212320382 no 3036 0.126246150923782 4166 X1259
SGTC_1154 4088-0362 150 µM -1.15193713881836 0.109145941903353 no 3037 0.124673452763128 4250 6618304
SGTC_533 1222-0222 6.71 µM -1.15202498133321 0.109127683758313 no 3038 0.124655404004781 4263 3982874
SGTC_1471 k673-0312 37 µM -1.15206570855698 0.109119219313291 no 3039 0.124647036514556 4179 24099884
SGTC_2993 9054257 71.4286 µM -1.15501269448669 0.108507991244206 no 3040 0.124042614018608 4166 6470217 YGL055W OLE1
SGTC_1037 k284-1091 78.7 µM -1.15597075445632 0.108309813603702 no 3041 0.123846559791135 4233 3334711
SGTC_2328 6201408 200 µM -1.16054505215243 0.107367196704656 no 3042 0.122913481102954 4254 2890418
SGTC_1986 st071812 45 µM -1.1628199108034 0.106900628785583 no 3043 0.122451288521924 4191 11838594
SGTC_1425 4048-4433 7.33 µM -1.16328704740866 0.106805001512093 no 3044 0.122356529552472 4308 23734946
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.16406253609857 0.106646387971283 no 3045 0.122199334821185 4171 5355888
SGTC_3273 9137859 49.47 µM -1.16461154364054 0.106534200281731 no 3046 0.122088134499005 4357 2377234
SGTC_999 SEC7.066 22.7 µM -1.16577518109451 0.106296696926419 no 3047 0.121852677143773 4208 740511 YDR170C SEC7
SGTC_2897 9048598 12.99 µM -1.16677673543159 0.106092581835282 no 3048 0.121650272256087 4229 6467404
SGTC_1921 5740136 50 µM -1.16895727178053 0.105649171899529 no 3049 0.12121042345807 4208 1774243
SGTC_2414 st077232 92.9 µM -1.17169042886293 0.105095281454847 no 3050 0.120660683542835 4202 729801
SGTC_36 0335-0881 14.2 µM -1.17275399210659 0.104880313098843 no 3051 0.120447236420935 4151 23828853
SGTC_764 1951-2361 146 µM -1.17312855216353 0.104804682537174 no 3052 0.120372129101929 4267 5438930
SGTC_389 tpck 16.7 µM -1.17394734734589 0.104639490277698 no 3053 0.120208058015529 4294 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2623 humulene 100 µM -1.17508513731852 0.104410253929567 no 3054 0.119980328104767 4271 6187145 An anti-inflammatory.
SGTC_2570 licareol 100 µM -1.17707632662386 0.104009954934452 no 3055 0.119582521501352 4250 443158
SGTC_2549 cedrol 20.94 µM -1.18004256889203 0.103415701572255 no 3056 0.118991642285155 4207 6708665 A sedative which affects the nervous system.
SGTC_2388 9080168 200 µM -1.18036013347041 0.103352227417717 no 3057 0.118928505406417 4275 15943073
SGTC_3332 9141069 11.198 µM -1.18081884160194 0.103260591719184 no 3058 0.118837348722247 4222 17332883
SGTC_1409 3909-8004 61.9 µM -1.18086492322237 0.103251389298415 no 3059 0.118828193889834 4311 2119279
SGTC_1504 k297-0033 30 µM -1.18220882342264 0.102983276583374 no 3060 0.118561426236407 4145 4388117
SGTC_2465 5809242 33.21 µM -1.18332453720457 0.102761072360867 no 3061 0.118340275923393 4316 2731748
SGTC_1919 st067113 52.3 µM -1.18334819254038 0.102756364967326 no 3062 0.118335590259107 4289 1268243
SGTC_1904 st060225 78 µM -1.18623100625011 0.102183859947357 no 3063 0.11776554230465 4220 66595
SGTC_560 2332-1943 155 µM -1.18834708142597 0.101765102563325 no 3064 0.117348347935567 4247 21177716
SGTC_555 4296-0685 37 µM -1.18872255003906 0.101690930477679 no 3065 0.11727443197012 4246 2908540 YHR072W ERG7
SGTC_2849 9019321 12.99 µM -1.1891066045239 0.101615103021681 no 3066 0.11719885988554 4303 16489627
SGTC_2850 9015429 58.44 µM -1.18966389789144 0.101505144630356 no 3067 0.117089260186588 4289 6457570
SGTC_1682 st012968 530 nM -1.19314341519064 0.100820567517537 no 3068 0.116406605466138 4293 24207270
SGTC_1111 tnp00062 510.699 nM -1.19545229336155 0.100368169606836 no 3069 0.115955182417064 4326 676306
SGTC_926 2268-1401 59.4 µM -1.19980784933852 0.0995187854817297 no 3070 0.115106987502552 4251 2931578
SGTC_3227 9130768 49.47 µM -1.20198769854268 0.0990956673471833 no 3071 0.114684147102251 4341 17720899
SGTC_520 3584-0023 682 µM -1.20221513942455 0.0990515960077089 no 3072 0.114640092584723 4302 1340790
SGTC_2969 9091408 28.7 µM -1.20309122872468 0.0988819696917879 no 3073 0.11447050963822 4244 4286311
SGTC_157 1348-1695 65.819 µM -1.20421438561652 0.0986648177648672 no 3074 0.114253363602462 4222 5380510
SGTC_2005 4024620 188 µM -1.21155419465146 0.0972543226290309 no 3075 0.112841538744446 4260 236743
SGTC_975 1335-0046 28.5 µM -1.21213933293271 0.097142516332468 no 3076 0.112729524798432 4302 16486740
SGTC_1171 0368-0077 21.4 µM -1.2129945657381 0.0969792710000838 no 3077 0.11256594909572 4249 3239779
SGTC_209 4077-0173 175.592 µM -1.21446444681756 0.0966991733347845 no 3078 0.112285209192225 4276 15993494
SGTC_2355 9061122 103.12 µM -1.2160853605278 0.0963909845726505 no 3079 0.111976203326036 4305 5302957
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.21615964476468 0.0963768780245094 no 3080 0.111962056599313 4299 5024745
SGTC_528 3492-0019 172 µM -1.21942034828035 0.0957591656381669 no 3081 0.111342345316689 4308 2869262
SGTC_1373 2887-0003 58.5 µM -1.22364010924811 0.0949640980926747 no 3082 0.110544010926705 4263 776948
SGTC_2979 9012552 45.46 µM -1.22514710828543 0.0946813381307251 no 3083 0.110259899298142 4313 17100905
SGTC_1319 1306-0155 43.7 µM -1.22999513704208 0.0937759065143479 no 3084 0.109349462946375 4353 3122360
SGTC_433 pimozide 108 µM -1.23711909250953 0.0924570371724724 no 3085 0.108021436312414 4230 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2731 amoxapine 43.43 µM -1.24257289699981 0.0914566780638368 no 3086 0.10701263124993 4479 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_962 1254-0300 21.5 µM -1.2472684901876 0.0906018392380757 no 3087 0.106149533516203 4293 7340576
SGTC_2611 pyromycin 23.93 µM -1.24899897668306 0.0902883021755876 no 3088 0.105832724066742 4290 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.24993393224166 0.0901192385335654 no 3089 0.105661841380779 4304 16623 A steroid.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.25168898176359 0.0898025164234876 no 3090 0.105341608257152 4350 2374 Ca(2+)-ATPase inhibitor.
SGTC_1170 0310-0127 64.8 µM -1.25337443958483 0.0894991326248971 no 3091 0.105034734575995 4335 774975
SGTC_5 0352-0601 109.883 µM -1.25699126831847 0.0888506745373237 no 3092 0.104378398700998 4231 762456
SGTC_3241 9133421 49.47 µM -1.25737304652893 0.088782430496493 no 3093 0.104309292268167 4409 17018221
SGTC_826 1683-5028 118 µM -1.25979888147043 0.0883497166631061 no 3094 0.103870961700906 4366 722377
SGTC_170 4197-0004 226 µM -1.26268831838877 0.0878363599721318 no 3095 0.103350606900547 4328 218692
SGTC_2475 5812728 15.03 µM -1.26446194932457 0.0875223487325942 no 3096 0.103032134891944 4289 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2903 5923464 63.88 µM -1.26813518118904 0.0868746893684154 no 3097 0.102374839878739 4354 2876576
SGTC_1321 1326-2144 215 µM -1.27399043665046 0.0858497116143055 no 3098 0.101333402721187 4339 3513030
SGTC_1926 methyl fluorone black 53.6 µM -1.27531571850262 0.0856189788042518 no 3099 0.101098758195368 3992 72721 Reacts with homocysteine.
SGTC_1744 st037937 38.9 µM -1.27559866775392 0.0855697772792115 no 3100 0.101048712649874 4384 1016152
SGTC_736 0958-0254 92.6 µM -1.27786954156951 0.0851756657839816 no 3101 0.100647714588681 4418 6812352
SGTC_596 1155-0152 116 µM -1.27840552287291 0.0850828446231435 no 3102 0.100553238858553 4365 280313
SGTC_627 1391-0720 175 µM -1.27921992100188 0.0849419524137886 no 3103 0.100409811335207 4320 997839
SGTC_1207 2099-0101 141 µM -1.27994540514613 0.0848165898296021 no 3104 0.100282168654649 4358 5837381
SGTC_723 4182-0001 115 µM -1.28287497796514 0.0843117749007767 no 3105 0.0997679402402731 4367 744821 YLR208W SEC13
SGTC_602 3130-1533 38.1 µM -1.29048923644495 0.083010259299542 no 3106 0.0984404233024342 4401 720941
SGTC_781 4335-2806 94.4 µM -1.29431990626545 0.0823612186961065 no 3107 0.0977774716644248 4416 845254
SGTC_902 1120-0002 2.07 µM -1.29624991327098 0.0820356635847277 no 3108 0.0974446991938316 4350 3280475
SGTC_1748 st037455 53.6035 µM -1.29845700893863 0.0816645583418559 no 3109 0.0970651700623763 4394 580690
SGTC_1459 k035-0031 35.7 µM -1.30058587833313 0.0813078067236407 no 3110 0.096700121671442 4097 3877128 YMR208W ERG12
SGTC_3016 9080866 49.47 µM -1.30447717215007 0.0806587520203681 no 3111 0.0960354689364551 4323 17066299
SGTC_1819 st053448 58.6 µM -1.30458049522273 0.0806415715648368 no 3112 0.0960178667269331 4278 2857616
SGTC_2406 ethylparaben 405.7 µM -1.31133554657935 0.0795243356309164 no 3113 0.0948722119856174 4358 8434 A possible steroid mimic.
SGTC_637 1181-0519 7.26 µM -1.31542062261523 0.0788544006855248 no 3114 0.0941842892045006 4384 6252091 YGR060W ERG25
SGTC_1993 st073995 70.8 µM -1.31705358571528 0.0785878011490026 no 3115 0.0939103317038385 4367 3098394
SGTC_2134 5324836 1.464 µM -1.31920825506338 0.0782370733758711 no 3116 0.0935497496277196 4351 699272
SGTC_1619 st003326 88.7 µM -1.32068179742096 0.0779979009030514 no 3117 0.0933037429586016 4359 2849032
SGTC_1275 0867-0008 21.1 µM -1.32111202023418 0.0779281756435548 no 3118 0.0932320078422563 4359 3422836
SGTC_642 0335-0876 158 µM -1.32163233754071 0.0778439121727088 no 3119 0.0931453048767017 4430 6812350
SGTC_1964 st076914 61 µM -1.32592287561829 0.0771517094529832 no 3120 0.0924326224633441 4421 24208661
SGTC_534 k292-0788 63.4 µM -1.32820782140373 0.0767849874494915 no 3121 0.0920547306337698 4424 4146317
SGTC_413 propylparaben 100 µM -1.33039496599652 0.0764352049623735 no 3122 0.0916940861530258 4371 7175 A pharmaceutical preservative.
SGTC_631 k072-0230 41.5 µM -1.34084111411051 0.0747812908391644 no 3123 0.0899860221531484 4390 5773147
SGTC_834 0312-0008 75.7 µM -1.34389472501187 0.074303014698595 no 3124 0.089491216020784 4415 6385573 YIL048W NEO1
SGTC_703 3875-0075 71.8 µM -1.35041255655174 0.0732899683141321 no 3125 0.0884418426693262 4447 2850814
SGTC_966 1300-0360 30.2 µM -1.35115753728308 0.0731748543810657 no 3126 0.0883224867773899 4396 70588
SGTC_3221 9128209 49.47 µM -1.35864621383218 0.0720253818425328 no 3127 0.0871293617246589 4433 16460723
SGTC_3032 9089427 49.47 µM -1.35933604454873 0.0719201967241889 no 3128 0.0870200635966294 4392 17173707
SGTC_3210 9128157 49.47 µM -1.3625486772141 0.0714318868173657 no 3129 0.0865123965547065 4380 17590849
SGTC_2614 arthonioic acid 13.39 µM -1.36420026348506 0.0711818432886213 no 3130 0.0862522726503771 4269 6710684
SGTC_1664 st014217 9.02 µM -1.36445510614573 0.0711433210545009 no 3131 0.0862121872258117 4473 3982782
SGTC_2786 7743617 45.45 µM -1.36522118163065 0.0710276168160639 no 3132 0.0860917714421817 4346 583674
SGTC_75 0159-0059 199.013 µM -1.36628789893397 0.0708667459255677 no 3133 0.0859243088415492 4479 5377270
SGTC_1018 4259-0013 28.1 µM -1.36706438850527 0.0707498202192292 no 3134 0.0858025621168432 4456 6801262
SGTC_2639 lactacystin 53 µM -1.36945602632699 0.0703906128779385 no 3135 0.0854283857077279 4436 3870 A proteasome inhibitor.
SGTC_1564 D-Arginine 115 µM -1.37734572770612 0.0692155730205286 no 3136 0.0842026918881716 4422 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2190 6049624 200 µM -1.38173685906082 0.0685681653425615 no 3137 0.0835262562612911 4316 2265554
SGTC_842 0271-0008 11.1 µM -1.38317017133206 0.068357858747722 no 3138 0.083306346782338 4466 1221709
SGTC_1539 benzyladenosine 56 µM -1.38391996679394 0.068248041459321 no 3139 0.0831914811005842 4429 92208 A nucleotide analog.
SGTC_1385 3091-4834 14.1 µM -1.38781808492052 0.067679304112859 no 3140 0.0825962232016155 4415 4072814
SGTC_1836 st055642 81 µM -1.39228778975401 0.0670316858962893 no 3141 0.0819176337477755 4425 8571
SGTC_601 0986-0029 62.9 µM -1.393532585455 0.0668521826721912 no 3142 0.0817293991901748 4399 24747981
SGTC_17 0960-0276 49.807 µM -1.39420099769152 0.0667559492302481 no 3143 0.0816284583835764 4422 6821114
SGTC_2838 9002687 71.43 µM -1.39864439116671 0.0661189421835775 no 3144 0.0809598237737486 4413 6457060
SGTC_2267 7931562 200 µM -1.39963322042148 0.0659778257598168 no 3145 0.0808115903113898 4384 934880
SGTC_2276 7947513 42.08 µM -1.40399400194337 0.0653582783448167 no 3146 0.0801603178385909 4375 2105100
SGTC_1633 st005664 67.9 µM -1.40588399584269 0.0650911679041568 no 3147 0.079879287200256 4413 2063822
SGTC_689 0833-0039 98 µM -1.40959488500676 0.0645691781849341 no 3148 0.0793296691088461 4404 5374726
SGTC_460 trequinsin 123 µM -1.4100893122903 0.0644998760775314 no 3149 0.0792566563506952 4525 5537 A vasodilator.
SGTC_2453 5731132 22.18 µM -1.41136259081484 0.0643216711926821 no 3150 0.0790688637723728 4472 1362040
SGTC_1415 3966-0071 78.1 µM -1.41468911347945 0.0638579049156816 no 3151 0.0785798338446888 4347 2893185
SGTC_1052 3253-3998 198 µM -1.41617666700123 0.0636513613993316 no 3152 0.0783618928098683 4404 5450317
SGTC_1905 st060207 84.5 µM -1.41805382597889 0.0633914642676919 no 3153 0.0780875252862607 4436 1948547
SGTC_93 0109-0045 59.227 µM -1.422858784533 0.0627299694781568 no 3154 0.0773885481139773 4569 88733
SGTC_665 3914-0008 307 µM -1.42836689438314 0.0619783040366494 no 3155 0.0765931413860931 4412 1069549
SGTC_3355 9151058 44.0485 µM -1.42898527036949 0.0618943579171009 no 3156 0.0765042335330934 4474 17015728
SGTC_2455 5377712 9.75 µM -1.42981403629246 0.0617819900222077 no 3157 0.0763851997235302 4447 2243908
SGTC_3031 9088762 49.47 µM -1.43161321515733 0.0615385972402136 no 3158 0.0761272727433774 4429 205253
SGTC_675 1309-0189 238 µM -1.43339580846494 0.0612981873055929 no 3159 0.0758723777893448 4467 4246530
SGTC_3083 9117465 49.47 µM -1.43353191484825 0.0612798614759554 no 3160 0.0758529425290666 4418 16420915
SGTC_125 0133-0007 11.75 µM -1.43419472840907 0.0611906791626309 no 3161 0.0757583504994662 4537 26541
SGTC_2654 protoveratrine a 100 µM -1.43802231386075 0.0606776557415856 no 3162 0.0752138615071246 4477 5702278 A heart drug and vasodilator.
SGTC_1505 k297-0037 20.6 µM -1.43824352765928 0.0606481089032708 no 3163 0.0751824844183995 4446 4089396
SGTC_2234 tolnaftate 200 µM -1.43868583833624 0.0605890645920796 no 3164 0.0751197767541124 4566 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_292 k038-0015 474 µM -1.44025355775224 0.0603801509022248 no 3165 0.0748978378112681 4451 46368540
SGTC_3324 9138759 60.749 µM -1.44045062884475 0.0603539292178414 no 3166 0.0748699742738502 4486 45595710
SGTC_954 1189-0853 2.85 µM -1.44129275733082 0.0602419785425922 no 3167 0.0747509962884316 4380 2828194
SGTC_2601 securinine 100 µM -1.44311767841373 0.059999935451708 no 3168 0.0744936620716954 4421 442872 A GABA receptor antagonist.
SGTC_2264 7948757 110.76 µM -1.44984482997914 0.0591142721228791 no 3169 0.0735508974875979 4444 2971411
SGTC_1684 st024538 14.6195 µM -1.45180377337558 0.058858304441603 no 3170 0.073278087212736 4429 6732859
SGTC_2718 lomofungin 53.02 µM -1.45391913916422 0.058582875181327 no 3171 0.0729843629355534 4447 5351222 A RNA synthesis inhibitor.
SGTC_430 0958-0115 16.4 µM -1.45448062309062 0.0585099378844359 no 3172 0.0729065509105801 4398 6833180
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.45487837964166 0.0584583120903503 no 3173 0.0728514671258046 4386 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_779 1360-0071 233 µM -1.45769089039865 0.0580942894862089 no 3174 0.0724628820083703 4497 7566
SGTC_472 calcifediol 10 µM -1.45840193367122 0.0580025419857159 no 3175 0.0723648939997466 4501 5283731 A vitamin D metabolite.
SGTC_860 0443-0016 25.1 µM -1.46598605151288 0.0570310167882538 no 3176 0.0713260434501 4498 5337942
SGTC_2364 9055074 200 µM -1.46719278708787 0.0568776222940551 no 3177 0.0711618092604165 4459 6470630
SGTC_1019 4262-0212 3.4 µM -1.47320387039913 0.0561183567381718 no 3178 0.0703480358877508 4481 4677213
SGTC_1996 st072960 66.8 µM -1.47418892946936 0.0559946987462032 no 3179 0.0702153648606414 4512 1719405
SGTC_1130 3454-2858 15.9 µM -1.47600135836176 0.0557677396643296 no 3180 0.0699717637877552 4450 715628 YIL048W NEO1
SGTC_1637 st007924 17.4 µM -1.47624444342655 0.0557373549345496 no 3181 0.0699391412463564 4386 683336
SGTC_1062 mesoridazine 14.2 µM -1.47703635915409 0.0556384590077763 no 3182 0.0698329456075829 4527 4078 A neuroleptic.
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.48027545207409 0.0552353959887066 no 3183 0.0693998757934936 4492 15053
SGTC_317 4495-0002 170 µM -1.489426452501 0.0541091270553676 no 3184 0.068187553580251 4499 15991618
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.49403874305829 0.0535483946295861 no 3185 0.0675827466032199 4521 66535 A nucleotide analog.
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.4960597615668 0.0533041473928804 no 3186 0.0673190412432825 4490 641818 YHR062C RPP1
SGTC_2755 lomerizine 42.69 µM -1.496854792918 0.0532083073868267 no 3187 0.0672155226897863 4432 3949 A calcium channel blocker.
SGTC_1302 1159-0335 255 µM -1.49754310187083 0.0531254430043008 no 3188 0.0671259995672972 4506 649284
SGTC_1758 st042942 75.2445 µM -1.50713197664473 0.0519816640778261 no 3189 0.0658884159405665 4472 669317
SGTC_1299 1079-1439 3.74 µM -1.50941366144629 0.0517124029205112 no 3190 0.0655965520130147 4485 323161
SGTC_2485 5633444 17.78 µM -1.51429399580318 0.0511401978682594 no 3191 0.0649756453587633 4475 5724239
SGTC_880 0833-0487 87.2 µM -1.51605973342338 0.0509344157537584 no 3192 0.0647521244487486 4485 76075
SGTC_2066 5222451 176 µM -1.51775830452523 0.0507370839004272 no 3193 0.0645376699078097 4438 2281147
SGTC_2760 etidronate 98.04 µM -1.5291954715561 0.0494241733364722 no 3194 0.0631079964450441 4461 3305 A chelator and antioxidant.
SGTC_521 r062-0005 13.8 µM -1.53181955394435 0.0491268043853866 no 3195 0.0627834846849341 4440 2832033
SGTC_1036 k216-0215 33.5 µM -1.53252795731569 0.0490467714183118 no 3196 0.0626961020173804 4470 622330
SGTC_2070 5230947 200 µM -1.54152994529963 0.048038802606153 no 3197 0.0615939303147952 4594 2835538
SGTC_2173 5763948 167 µM -1.55219816931842 0.0468658024131486 no 3198 0.0603074070056339 4486 2867177
SGTC_1317 1273-0028 910 nM -1.55430975379394 0.0466363741540117 no 3199 0.0600552740183536 4540 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_526 4469-0568 170 µM -1.55734203139733 0.046308487862951 no 3200 0.0596946506158604 4491 2901964
SGTC_3022 9087993 49.47 µM -1.55800282280448 0.0462372813572202 no 3201 0.0596162894856654 4597 17173644
SGTC_2857 9024691 58.44 µM -1.56007499059308 0.0460145557536081 no 3202 0.059371080427433 4545 16478292
SGTC_2450 5739737 12.93 µM -1.56076380580438 0.0459407100594587 no 3203 0.0592897451220648 4540 2262825
SGTC_1218 1348-1416 30.7 µM -1.56568529142321 0.0454158598919401 no 3204 0.0587111556782496 4499 6787668
SGTC_140 0062-0056 502.533 µM -1.56618066243013 0.0453632994319069 no 3205 0.0586531642373899 4439 3758964
SGTC_2556 citropten 84.59 µM -1.56725323644379 0.0452496635265058 no 3206 0.0585277556387528 4520 2775 A potential DNA crosslinker.
SGTC_3333 9141820 12.094 µM -1.57322818167901 0.0446208214372475 no 3207 0.0578329960183197 4514 1939433
SGTC_1163 k060-0048 49.9 µM -1.57779611923231 0.0441448254799635 no 3208 0.0573062278369914 4540 6809982
SGTC_2990 9074105 71.4286 µM -1.5791326271792 0.0440063331451828 no 3209 0.0571528196633543 4470 6502001
SGTC_1387 3342-1166 1.8 µM -1.58113283220879 0.0437997216099346 no 3210 0.0569238345570022 4529 3418228
SGTC_1557 sumaresinolic acid 42.3 µM -1.58301502001038 0.0436060160314303 no 3211 0.056709020492373 4509 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1568 digitonin 820 nM -1.59230643593788 0.0426598963233155 no 3212 0.0556579337743126 4522 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_331 k048-0133 24.5 µM -1.59853925969023 0.0420345763769108 no 3213 0.0549615076667938 4539 6813582
SGTC_454 lyso-paf C-16 6.67 µM -1.60283328553484 0.0416081022427062 no 3214 0.0544857329812239 4558 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1447 4239-0816 81.9 µM -1.60293304626023 0.0415982360246201 no 3215 0.0544747184125832 4561 1341554
SGTC_1075 aripiprazole 15.2 µM -1.6048615337247 0.0414078830596563 no 3216 0.0542621402532162 4594 60795 An atypical antipschotic. YIL048W NEO1
SGTC_35 0133-0054 64.071 µM -1.60708733814603 0.0411890613820301 no 3217 0.0540176052367547 4506 99677
SGTC_648 0375-0473 33.3 µM -1.60881722186155 0.0410196425686521 no 3218 0.0538281569932494 4534 1713139
SGTC_1475 4092-1048 11.7 µM -1.61213091280741 0.0406966895195286 no 3219 0.0534667275764474 4560 2881759
SGTC_2459 5811157 9.22 µM -1.61257405040002 0.04065365808204 no 3220 0.0534185399858203 4502 2870684 YBR192W RIM2
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.617961976988 0.0401334049473143 no 3221 0.0528353961063698 4585 5106787 A p450 inhibitor.
SGTC_329 k048-0121 21.3 µM -1.62742481640888 0.0392327823074092 no 3222 0.0518234522226603 4558 6832902
SGTC_483 fpl-64176 144 µM -1.62933448311472 0.0390530401027287 no 3223 0.0516211150288226 4673 3423
SGTC_583 1488-1091 88.9 µM -1.63041156064149 0.038951959156414 no 3224 0.0515072714749178 4654 4303273
SGTC_3243 9134147 49.47 µM -1.63374501480762 0.0386404723621972 no 3225 0.0511562010651665 4652 24282180
SGTC_1328 1441-0025 69.2 µM -1.63483401232105 0.0385391544527453 no 3226 0.0510419242987301 4580 4562601
SGTC_1545 lovastatin 49.4 µM -1.63674431750234 0.0383619469655533 no 3227 0.0508419523871392 4592 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1308 1187-1617 41.4 µM -1.63697237606602 0.0383408358048007 no 3228 0.0508181208140728 4587 2882570
SGTC_1015 4130-4525 82 µM -1.63728234008108 0.0383121579215897 no 3229 0.0507857445782783 4568 1363237
SGTC_3299 9121982 43.1275 µM -1.63978624842496 0.0380811369335683 no 3230 0.0505248092172223 4560 17594604 YPL160W CDC60
SGTC_1189 1431-2119 7.28 µM -1.64248230745241 0.0378336590686186 no 3231 0.0502450449105579 4572 3107275
SGTC_1763 st044482 94.5 µM -1.64305732980044 0.0377810465427171 no 3232 0.0501855361190615 4546 88505
SGTC_1915 st067105 30.6 µM -1.65432822229933 0.0367618006788619 no 3233 0.0490304208447293 4515 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_96 0929-0093 37.281 µM -1.65734619005753 0.0364927309698391 no 3234 0.0487247518936083 4574 6991579
SGTC_1443 4112-3303 14 µM -1.66061223256897 0.0362033617583358 no 3235 0.0483956753024303 4608 704433
SGTC_1167 k781-0610 148 µM -1.66629411100173 0.035704429498318 no 3236 0.047827424551928 4600 4525169
SGTC_2053 5265679 138 µM -1.66776222041865 0.0355764333431584 no 3237 0.0476814691782852 4496 764595
SGTC_315 k915-0449 187 µM -1.66868658452628 0.0354960364154712 no 3238 0.0475897546085276 4604 20970215 YNL149C PGA2
SGTC_303 1348-1668 34.2 µM -1.6733931152526 0.035088991101511 no 3239 0.0471249661516613 4588 5380509
SGTC_614 0462-0418 107 µM -1.67972372439247 0.0345475356632791 no 3240 0.0465055408197251 4354 5188303
SGTC_2307 7538926 6.34 µM -1.67998104330673 0.0345256732163548 no 3241 0.0464805020432264 4530 96582
SGTC_2600 tangeritin 87.95 µM -1.6808337773723 0.0344533040632368 no 3242 0.0463976029001806 4500 68077 A bioactive flavone.
SGTC_2365 9042475 200 µM -1.68709817375769 0.0339254748861672 no 3243 0.045792238082589 4600 6464479
SGTC_341 1486-1430 230 µM -1.69937505210752 0.0329103302765857 no 3244 0.044624269760496 4548 2054753 YPL210C SRP72
SGTC_3320 9137005 35.139 µM -1.70729002223699 0.0322692331053928 no 3245 0.043884079869964 4616 4908713
SGTC_870 0573-2213 57.6 µM -1.70883401989835 0.032145381556025 no 3246 0.0437408495534999 4587 3916321
SGTC_2163 5671233 125 µM -1.70956051547783 0.0320872417239544 no 3247 0.0436735861533465 4537 701023
SGTC_231 b-estradiol 524 µM -1.71813157303255 0.0314078502755582 no 3248 0.0428863095352619 4612 450 A steroid.
SGTC_2197 6588183 93.1375 µM -1.7186469149346 0.0313673832528874 no 3249 0.0428393417822856 4625 884136
SGTC_1274 0865-0114 173 µM -1.72185573887568 0.0311163804923942 no 3250 0.0425478272759479 4595 870624
SGTC_1268 0828-0275 2.46 µM -1.72628957908531 0.0307722901214065 no 3251 0.0421476645946247 4633 745337
SGTC_269 exalamide 29 µM -1.73285475567486 0.0302685867972264 no 3252 0.0415607438534888 4590 3316 A derivative of salicylamide.
SGTC_531 3788-1495 174 µM -1.73386971310174 0.0301913289784174 no 3253 0.0414706014048559 4592 2896655
SGTC_963 1269-2853 151 µM -1.73794535442246 0.0298827383859392 no 3254 0.0411102214986583 4605 3668223
SGTC_1254 0550-0035 264 µM -1.74115623359809 0.0296414704668244 no 3255 0.0408280982803764 4584 15121435
SGTC_532 1548-0774 215 µM -1.74158975209325 0.0296090197645067 no 3256 0.0407901279151638 4646 5932993
SGTC_261 5-fluorouridine 15.376 µM -1.74279246606255 0.029519145848082 no 3257 0.0406849364063457 4613 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2945 9067681 61.76 µM -1.74540360823271 0.0293248051735412 no 3258 0.0404573190214348 4635 16456930
SGTC_722 3534-0461 190 µM -1.76010075795497 0.0282506562404333 no 3259 0.0391953621520409 4617 658262
SGTC_371 0195-0006 7.36 µM -1.76067584234089 0.0282093006741812 no 3260 0.0391466418998257 4461 3928593
SGTC_2203 7227154 166.4 µM -1.76219666239632 0.0281001780014863 no 3261 0.0390180379130925 4632 896304
SGTC_139 0099-0334 718.624 µM -1.77453058288763 0.0272281084887014 no 3262 0.0379877140028538 4602 97690
SGTC_2011 4012611 177 µM -1.78779890224316 0.0263152987579575 no 3263 0.0369042290294976 4599 2049887
SGTC_2702 st077768 96.8 µM -1.78895569939198 0.0262369423523218 no 3264 0.0368109751844884 4580 6484119
SGTC_748 act1.228 77.9 µM -1.7952547109106 0.0258136900396144 no 3265 0.0363065635911527 4604 4421505 YNR035C ARC35
SGTC_3046 9092212 49.47 µM -1.80598247790732 0.0251060103433392 no 3266 0.0354605382925628 4683 25236637
SGTC_251 melphalan 456.522 µM -1.80921640846347 0.0248958943601249 no 3267 0.0352086947206972 4657 460612 A DNA alkylator.
SGTC_1947 st076332 61.6 µM -1.81653887432893 0.0244255817279971 no 3268 0.0346438751586865 4513 24208416
SGTC_1026 k007-1105 30.6 µM -1.82480247886722 0.0239038017574488 no 3269 0.0340154208333022 4598 7066794
SGTC_1303 1160-0052 261 µM -1.83165837673541 0.0234780472868071 no 3270 0.0335011668011992 4599 3562476
SGTC_2405 ticlatone 3.52 µM -1.83205151530926 0.0234538278428938 no 3271 0.0334718729579688 4447 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1389 3405-0187 19 µM -1.85636795175727 0.0219961356491636 no 3272 0.0317005647602827 4634 799890
SGTC_1750 st081859 2.357 µM -1.86199121634309 0.0216701506228188 no 3273 0.0313021641721597 4573 5291695
SGTC_274 sirtinol 40.1 µM -1.86206938828165 0.0216656478575693 no 3274 0.0312966551133957 4679 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_572 0960-0087 17.7 µM -1.86547395182094 0.0214703078299103 no 3275 0.0310575000193574 4621 6796365
SGTC_2105 5350118 200 µM -1.8665575152647 0.0214084505218839 no 3276 0.0309817025729875 4617 2133313
SGTC_2280 7785178 200 µM -1.87185133818442 0.0211084044081314 no 3277 0.0306135867159733 4636 2954328
SGTC_2043 5101342 149 µM -1.87616388799563 0.0208666122888381 no 3278 0.0303163895556427 4661 678451
SGTC_3000 9075062 71.4286 µM -1.87902832983826 0.0207073105942318 no 3279 0.0301203125345319 4641 17057871
SGTC_819 1013-0258 27.7 µM -1.87929321234144 0.020692631707672 no 3280 0.0301022340014679 4654 5753198
SGTC_1261 0712-0010 12.7 µM -1.88007412477552 0.0206494074762592 no 3281 0.0300489881865963 4634 2840123
SGTC_1213 1315-0166 115 µM -1.88246436548752 0.0205175804054395 no 3282 0.0298864968899745 4633 768401
SGTC_2189 6047310 154.431 µM -1.88359868629421 0.0204552700097129 no 3283 0.0298096398492593 4676 711535
SGTC_1994 st072947 40.9 µM -1.91929770352098 0.0185746084005214 no 3284 0.0274733342484526 4682 5286565 YDL195W SEC31
SGTC_1478 0453-0656 35.7 µM -1.92537991606488 0.0182693348835222 no 3285 0.0270909231569962 4700 5258496
SGTC_706 4262-0057 46.9 µM -1.92618141992964 0.0182294270177329 no 3286 0.0270408624833533 4666 883298
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.93030951485019 0.0180250587047579 no 3287 0.0267842494080752 4677 6708784 An antioxidant flavonoid
SGTC_639 0833-0042 114 µM -1.93135772926212 0.0179734771499574 no 3288 0.0267194143945803 4685 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2404 5161160 200 µM -1.94579917078741 0.0172755436602805 no 3289 0.0258394341426396 4637 2831543
SGTC_2291 7917025 104.35 µM -1.95036452170565 0.0170597798699425 no 3290 0.0255663436771296 4581 2964612
SGTC_1757 st041620 31.8375 µM -1.95912160724574 0.0166523515717112 no 3291 0.0250492734587092 4660 5289815
SGTC_2865 9030313 51.95 µM -1.96318008509985 0.0164663700628404 no 3292 0.0248126262718623 4650 42562754
SGTC_1770 st043884 66.3 µM -1.98178824698068 0.0156362437458349 no 3293 0.0237514727186413 4691 670149
SGTC_1612 st002233 45.4 µM -1.9842399250282 0.0155295960472537 no 3294 0.0236145498513245 4702 1035021
SGTC_1695 st026914 34.495 µM -1.98639881600603 0.0154362020715749 no 3295 0.023494529002344 4687 3289191
SGTC_2352 9027995 87.8 µM -2.00104089008836 0.014815420100707 no 3296 0.0226939917524657 4651 2997347
SGTC_830 4076-0286 57.8 µM -2.02947457673798 0.0136710541793157 no 3297 0.021204987948017 4723 6866659
SGTC_2072 5231554 129 µM -2.03728533815526 0.0133703731169929 no 3298 0.0208107281254839 4739 789545
SGTC_1826 st055655 41.6 µM -2.12542392833367 0.0103541484571311 no 3299 0.0167756277053429 4702 676168
SGTC_3304 9125678 46.087 µM -2.13372341457918 0.0101033617746533 no 3300 0.0164327141139471 4679 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2714 st079313 56.9 µM -2.16454479732221 0.00921783390888979 no 3301 0.0152112812073346 4718 2939799
SGTC_1025 k007-0731 70 µM -2.16815371074798 0.00911872599931757 no 3302 0.0150734966975187 4700 6256118
SGTC_1348 1493-0373 93.8 µM -2.1735164707574 0.00897317737669775 no 3303 0.0148707337666133 4734 3010129
SGTC_402 epigallocatechin gallate 10 µM -2.17663487210195 0.00888948118080574 no 3304 0.014753910570187 4706 65064 An antioxidant.
SGTC_2541 muurolladie-3-one 83.07 µM -2.1780840836091 0.00885081850807464 no 3305 0.0146998886687996 4677 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_342 k048-0088 23.3 µM -2.1783005135789 0.00884505716433015 no 3306 0.0146918354838486 4734 6820570
SGTC_2018 5133068 143 µM -2.20277343218978 0.00821442244320181 no 3307 0.0138053608065357 4704 785362
SGTC_768 0384-0033 77.3 µM -2.20752110010203 0.00809676285572398 no 3308 0.0136388372679247 4697 3965305 YMR134W ERG29
SGTC_3301 9125354 19.7965 µM -2.23230920549057 0.00750619299527688 no 3309 0.0127972669440904 4714 41905162
SGTC_1730 st033808 45.1 µM -2.24773763398323 0.00715807686688464 no 3310 0.012296462373442 4680 1045166
SGTC_2100 5377183 190 µM -2.25263334433625 0.0070506302629981 no 3311 0.0121411384415373 4747 2844202
SGTC_214 4373-3496 70 µM -2.25381102507272 0.0070249969456626 no 3312 0.0121040294647829 4749 3779166
SGTC_1107 amlodipine 47 µM -2.25783115102079 0.00693811370060018 no 3313 0.0119780941574844 4333 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_651 3253-0966 34.4 µM -2.25985788352685 0.00689467259938466 no 3314 0.0119150362756024 4747 781462
SGTC_2928 9011484 9.79 µM -2.26007194641275 0.00689009841697175 no 3315 0.0119083929638478 4701 2994751
SGTC_1610 st001799 48.1 µM -2.26540424362167 0.00677701725348685 no 3316 0.0117439420836718 4708 621897
SGTC_412 gemfibrozil 100 µM -2.28500672673417 0.00637527836113977 no 3317 0.0111562166666819 4720 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_612 0302-0167 22.4 µM -2.30676666076285 0.00595413718309502 no 3318 0.0105339158889793 4726 235821
SGTC_1767 st044992 70.3 µM -2.30914751409859 0.00590958960713231 no 3319 0.0104676984553059 4728 9600693
SGTC_1604 st002052 72.4 µM -2.30953270551562 0.00590241022927115 no 3320 0.0104570194892242 4750 6254834 YHR062C RPP1
SGTC_750 4073-0104 132 µM -2.32935299362108 0.00554327321366482 no 3321 0.00992018655704693 4502 22330957
SGTC_119 0121-0043 24.815 µM -2.35943021875545 0.00503531876059364 no 3322 0.009151511405262 4738 1092378
SGTC_2354 9060492 162 µM -2.41294714735053 0.00423313082292098 no 3323 0.00791205701327853 4744 6471895
SGTC_1614 st002383 48.6 µM -2.42563404534558 0.00406058794615892 no 3324 0.00764083557457723 4776 1947235
SGTC_1629 st005085 44.9 µM -2.45251227229573 0.00371568195902481 no 3325 0.00709312701193701 4728 24207091
SGTC_1943 st076331 65.2 µM -2.45913423083685 0.00363484818204676 no 3326 0.00696362671231124 4742 24208415
SGTC_1255 0566-0045 221 µM -2.47370503338407 0.00346251444907141 no 3327 0.00668600248139031 4756 2788469
SGTC_1608 st001473 40.5 µM -2.50250834688737 0.00314328526232953 no 3328 0.00616583588176526 4750 7292267
SGTC_660 4031-1742 102 µM -2.53226827150175 0.00284151813511629 no 3329 0.00566636244760913 4690 6738706
SGTC_765 1319-0117 244 µM -2.57908960954771 0.00241935973596868 no 3330 0.0049530542971322 4765 3487746 YGL099W LSG1
SGTC_2366 9070441 60.58 µM -2.58668960662846 0.00235645981069013 no 3331 0.0048451419934794 4748 6837235
SGTC_122 0236-0016 402.397 µM -2.58914960142363 0.00233641954002502 no 3332 0.00481066426797197 4758 6808838
SGTC_970 1315-0089 19.5 µM -2.59003056775697 0.00232928038371216 no 3333 0.00479837049761201 4770 6811083 YLR033W RSC58
SGTC_613 3914-0030 117 µM -2.59648914197731 0.00227754181042681 no 3334 0.00470909411833329 4643 1145395
SGTC_755 1995-0008 37.3 µM -2.69454688781847 0.00160994003125753 no 3335 0.00352422044548812 4776 689533
SGTC_1287 0971-0001 34.6 µM -2.71428677480217 0.00149934961092277 no 3336 0.00332093210589933 4781 4665869
SGTC_370 0180-0345 38.7 µM -2.74605333613136 0.00133585166758378 no 3337 0.00301584784097019 4681 3989527
SGTC_599 1935-0052 86.5 µM -2.77058012943685 0.00122094875395401 no 3338 0.00279782651177032 4785 9557311
SGTC_579 4491-1009 110 µM -2.80487734403476 0.00107540668399016 no 3339 0.00251678652067176 4784 1271041
SGTC_126 0417-1624 672.48 µM -2.81392186061386 0.00103977132508937 no 3340 0.00244705615762657 4792 41912 YDL195W SEC31
SGTC_1944 st076371 56.9 µM -2.82712785751615 0.000989682260838346 yes 3341 0.00234837854645845 4774 24208455
SGTC_2930 9013230 14.89 µM -2.85033480000036 0.000906993485048494 yes 3342 0.0021836615501018 4761 2995857
SGTC_647 0140-0236 81 µM -2.86778308544994 0.000849058310737836 yes 3343 0.00206679413146969 4795 990837
SGTC_1069 diphenylcyclopropenone 8.49 µM -2.89766742143221 0.000757677928254325 yes 3344 0.00187974510488521 4792 65057 A dermal irritant. YDR527W RBA50
SGTC_825 1988-2224 89.6 µM -2.92160086627187 0.000691124584065834 yes 3345 0.00174118747411233 4783 1180859
SGTC_2484 5809818 12.04 µM -2.94328786264831 0.000635517470858188 yes 3346 0.00162373150653803 4764 2870548
SGTC_2300 7976697 71.57 µM -2.98475635249034 0.00054052107919086 yes 3347 0.00141902141291761 4742 2236109
SGTC_1335 1486-0900 202 µM -3.03836975163828 0.000437141821385113 yes 3348 0.0011893095205822 4793 X1335
SGTC_2085 5307070 144.047 µM -3.07850546080478 0.000372100017109822 yes 3349 0.00104020858420328 4777 2840351
SGTC_2929 9013348 24.6 µM -3.14264054748992 0.000286533401497631 yes 3350 0.000837156551314326 4783 2995952
SGTC_409 arachidonic acid 100 µM -3.16509332510773 0.000261188995539673 yes 3351 0.000775166080866981 4793 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2302 7771753 200 µM -3.282790828897 0.000159200613840202 yes 3352 0.000513924507058944 4768 2203047
SGTC_582 0987-0078 156 µM -3.35094226088517 0.000118640748979846 yes 3353 0.000402685464170241 4804 1625765
SGTC_141 0443-0274 32.331 µM -3.36309632356732 0.000112514923737388 yes 3354 0.000385367329815167 4780 1627241
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -3.46037600897157 7.31514212116311e-05 yes 3355 0.000269710794189386 4800 688664
SGTC_1879 gemcitabine 100 µM -3.64275040322769 3.16713394084767e-05 yes 3356 0.000134870183019786 4799 60750 A nucleoside analog which inhibits DNA replication.