SGTCid condition conc unit OPI3|YJR073C.score OPI3|YJR073C.strain.pval OPI3|YJR073C.strain.significant OPI3|YJR073C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2743 auranofin 4.32 µM 11.9032186201677 2.42843036872855e-22 yes 1 5.69345068909141e-33 1 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_669 0108-0021 26.2 µM 11.2716269366025 3.13000901564756e-20 yes 2 9.0595270630061e-30 3 17201
SGTC_2089 5281248 129.67 µM 10.3806704044703 1.91135931088777e-17 yes 3 1.51817707868283e-25 2 2737878
SGTC_439 amiodarone 34.4 µM 10.3228478483562 2.84723347325414e-17 yes 4 2.77752872700915e-25 14 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_55 0767-0285 6.563 µM 10.1081055408985 1.22740601854167e-16 yes 5 2.54290891042522e-24 3 3116166
SGTC_2736 butenafine 14.65 µM 10.0494429911644 1.82005034774779e-16 yes 6 4.61940704389248e-24 1 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_781 4335-2806 94.4 µM 10.0098245797346 2.37185196678169e-16 yes 7 6.8998505612534e-24 3 845254
SGTC_59 0330-0160 1.33 µM 9.52443161803127 5.60160587561447e-15 yes 8 8.29737619317925e-22 10 4293482
SGTC_2241 6772625 37.8075 µM 9.24452510074916 3.23704955235004e-14 yes 9 1.18143816953966e-20 3 2285411
SGTC_146 3448-8650 53.125 µM 9.21646140570014 3.84875716838256e-14 yes 10 1.53533262501916e-20 21 2891488 YIL048W NEO1
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 9.10026943838611 7.83796221064752e-14 yes 11 4.50540035491743e-20 5 2374 Ca(2+)-ATPase inhibitor.
SGTC_794 k038-0031 316 µM 8.69657015653011 8.66974114112952e-13 yes 12 1.71033104005634e-18 24 6624242
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 8.63861143762802 1.213725235176e-12 yes 13 2.84501701879306e-18 14 6708739 YPR165W RHO1
SGTC_3037 9091026 49.47 µM 7.95929248680703 5.32989682173929e-11 yes 14 8.65128948098155e-16 14 25236398 YIL048W NEO1
SGTC_2085 5307070 144.047 µM 7.90355124435511 7.17437512150681e-11 yes 15 1.3553382121066e-15 2 2840351
SGTC_2289 7946404 165.07 µM 7.67934833441747 2.32362664055341e-10 yes 16 7.99499495224231e-15 18 1246120 YPR165W RHO1
SGTC_879 0831-1030 162 µM 7.63173996512631 2.9698971760127e-10 yes 17 1.15803121280125e-14 8 1549252
SGTC_1696 st025591 34.7925 µM 7.52156260628831 5.21150031454393e-10 yes 18 2.7062699058046e-14 6 2787147
SGTC_1067 clotrimazole 1.36 µM 7.45240348610949 7.38817120764313e-10 yes 19 4.58274525581447e-14 4 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1173 0443-0020 122 µM 7.31842732087885 1.44007551870262e-09 yes 20 1.25446920861859e-13 6 5331295
SGTC_1089 terbinafine 2.25 µM 7.16815808584291 3.00295160362905e-09 yes 21 3.80067495306241e-13 2 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2659 sanguinarine 24.21 µM 7.04330000333183 5.46979459283991e-09 yes 22 9.38697014127553e-13 5 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_300 r073-0011 5.04 µM 7.0144130085444 6.27488735970371e-09 yes 23 1.15458172817994e-12 3 2735780
SGTC_15 0266-0086 27.098 µM 6.93322286028443 9.2040163665506e-09 yes 24 2.05679687031604e-12 11 1712902 YIL048W NEO1
SGTC_790 1575-0012 79.1 µM 6.7081381088791 2.60411552136367e-08 yes 25 9.85616623130532e-12 3 378741 YLR208W SEC13
SGTC_270 tamoxifen 5.46 µM 6.69954385541455 2.70787424124861e-08 yes 26 1.04535559119311e-11 5 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1953 st076800 12.1 µM 6.59885468635216 4.26485299958952e-08 yes 27 2.07173091861836e-11 9 297591
SGTC_159 3970-0959 50 µM 6.58832343544883 4.47069940807386e-08 yes 28 2.22410408084725e-11 20 6615653
SGTC_221 trifluoperazine 10.304 µM 6.454178832906 8.09940576850408e-08 yes 29 5.44036316657652e-11 111 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1370 2001-0092 44.6 µM 6.25127622669539 1.9470176503011e-07 yes 30 2.03556049112118e-10 6 790957
SGTC_2430 5571206 200 µM 6.12213434546505 3.35660034618874e-07 yes 31 4.61650609893919e-10 23 1731771
SGTC_807 1315-0151 48 µM 6.04861690766266 4.55510484347113e-07 yes 32 7.30472949291382e-10 3 4011080
SGTC_2055 5235184 200 µM 5.99972575120034 5.57001810263049e-07 yes 33 9.88255320292784e-10 7 2836034
SGTC_181 1447-1644 8.07 µM 5.97276266434077 6.21945932678869e-07 yes 34 1.16634570265193e-09 14 534600
SGTC_639 0833-0042 114 µM 5.9637874884011 6.45136146783408e-07 yes 35 1.23228617126675e-09 13 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_315 k915-0449 187 µM 5.96180213434463 6.50377136950162e-07 yes 36 1.24735561744175e-09 21 20970215 YNL149C PGA2
SGTC_577 r071-0003 38.6 µM 5.95890040497869 6.58110930448148e-07 yes 37 1.26970397162493e-09 14 4568517 YMR134W ERG29
SGTC_3303 9125618 40.5795 µM 5.87267589257792 9.32811916757509e-07 yes 38 2.14408166983203e-09 15 22695467
SGTC_453 enantio-paf c16 10 µM 5.84902256274054 1.02564120485725e-06 yes 39 2.47235010099696e-09 55 13871343 A lipid and platelet activating factor
SGTC_813 k007-0158 173 µM 5.84445718891087 1.04455213255592e-06 yes 40 2.54111359100477e-09 10 6523916
SGTC_1239 0337-0584 35.4 µM 5.59218764653672 2.80857572516049e-06 yes 41 1.12113147322107e-08 18 914301 YML130C ERO1
SGTC_1788 fluconazole 20 µM 5.52534284689725 3.62563086171746e-06 yes 42 1.64421407162588e-08 34 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1773 st048542 73.5835 µM 5.49550218481619 4.0597116350571e-06 yes 43 1.94800060060144e-08 20 3237138
SGTC_137 0438-0332 85.389 µM 5.48304360187386 4.25527226302761e-06 yes 44 2.09034962201112e-08 66 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1661 st013063 9.66 µM 5.40273119270991 5.7493848697394e-06 yes 45 3.28168902776401e-08 8 721395
SGTC_725 1497-0963 19 µM 5.39739459356452 5.86466564363381e-06 yes 46 3.38077863734245e-08 8 3549977
SGTC_214 4373-3496 70 µM 5.37571796548562 6.35600565607211e-06 yes 47 3.8139056326266e-08 18 3779166
SGTC_61 0978-8327 98.565 µM 5.33620941382605 7.35425590119118e-06 yes 48 4.74548903715208e-08 9 6150059 YHR072W ERG7
SGTC_1090 efavirenz 20.7 µM 5.31485085625979 7.95446565581434e-06 yes 49 5.33723598797352e-08 5 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2271 7849410 118.62 µM 5.28279106160285 8.94377123058929e-06 yes 50 6.36152343324993e-08 6 972430
SGTC_666 0272-0154 136 µM 5.22505583254673 1.10279449611707e-05 yes 51 8.7051283666225e-08 27 6870312
SGTC_3018 9082602 49.47 µM 5.19188920036007 1.24263741520801e-05 yes 52 1.04085440932282e-07 37 17332089
SGTC_1066 ketoconazole 628 nM 5.17816900076659 1.30528610713999e-05 yes 53 1.12037101813315e-07 5 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_168 3970-0862 530.542 µM 5.17085760521592 1.33988658678245e-05 yes 54 1.16511042650298e-07 66 3135186
SGTC_450 aminopyrene 156 nM 5.16399875189398 1.37313692212715e-05 yes 55 1.20864653965454e-07 14 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_682 0kpi-0099 17 µM 5.16057391437592 1.39003209042599e-05 yes 56 1.23096967480122e-07 33 1714895 YML126C ERG13
SGTC_796 1234-0020 70.7 µM 5.15723960994105 1.40667039058037e-05 yes 57 1.25308506123832e-07 11 46495034
SGTC_513 4245-1575 41.7 µM 4.99302684689717 2.50579110787811e-05 yes 58 2.97201456121683e-07 74 719745
SGTC_188 3229-0966 278.469 µM 4.91677237807252 3.25755806849554e-05 yes 59 4.39913759966947e-07 15 5722370
SGTC_1754 st042065 16.137 µM 4.90432571127348 3.39892311175875e-05 yes 60 4.68744094529807e-07 131 1126236 YIL048W NEO1
SGTC_394 menadione 8.33 µM 4.90292895940044 3.4151443330026e-05 yes 61 4.720906875737e-07 18 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_129 0088-0017 176.636 µM 4.88774765014284 3.59624277473281e-05 yes 62 5.09980754718649e-07 51 182446
SGTC_2540 epiandrosterone 100 µM 4.75735077241508 5.57209125709272e-05 yes 63 9.80750795222101e-07 36 441302 A steroid.
SGTC_23 0213-0011 39.996 µM 4.75359670212061 5.64189333156226e-05 yes 64 9.99147290036961e-07 14 627608
SGTC_1831 st055328 12 µM 4.69501205243033 6.8439170381068e-05 yes 65 1.33295502655305e-06 14 1103068
SGTC_1084 voriconazole 435 nM 4.6662070120051 7.51980234025443e-05 yes 66 1.53405301957431e-06 15 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1699 st031318 29.054 µM 4.59983556321116 9.32387851507633e-05 yes 67 2.11412286247138e-06 17 5340658
SGTC_2776 terbinafine 19.92 µM 4.58931988356362 9.64459117656472e-05 yes 68 2.2234626001737e-06 40 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2077 5212015 200 µM 4.58663156624903 9.72822920628795e-05 yes 69 2.25227289839386e-06 45 780900
SGTC_964 1287-0107 19.4 µM 4.54568209161216 0.000110895411379328 yes 70 2.73788166684668e-06 25 51516812 YPR165W RHO1
SGTC_842 0271-0008 11.1 µM 4.49803275203089 0.00012898228737506 yes 71 3.42925667890759e-06 14 1221709
SGTC_86 0417-1630 471.922 µM 4.46805405334411 0.000141742182624698 yes 72 3.94671813755034e-06 127 3634867
SGTC_418 lividomycin a 100 µM 4.45890042333307 0.000145868073755641 yes 73 4.1190589667033e-06 5 72394 An antibiotic.
SGTC_90 0870-0863 4.608 µM 4.45361652297656 0.000148300670944766 yes 74 4.22179251245172e-06 35 1738164
SGTC_2434 5670830 169.91 µM 4.43808887932591 0.000155670986509636 yes 75 4.53805714696678e-06 15 1549830
SGTC_1149 3909-7961 23.3 µM 4.43265205114185 0.000158331689685911 yes 76 4.65405077707286e-06 8 735261
SGTC_2376 9072922 81.32 µM 4.38802699182525 0.000181835566326966 yes 77 5.71917913868992e-06 15 17087968
SGTC_718 1130-0073 349 µM 4.32525881953216 0.00022045621176144 yes 78 7.61764381442263e-06 11 6740020
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 4.31757817910383 0.000225675634076331 yes 79 7.88752706990734e-06 15 521171
SGTC_447 ml7 120 µM 4.28908749737943 0.000246060870551443 yes 80 8.9704344895285e-06 23 4216 Selective myosin light chain kinase inhibitor.
SGTC_470 aa-861 153 µM 4.25026187400701 0.000276613663815259 yes 81 1.06760364558911e-05 42 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_142 0335-0849 62.6745 µM 4.18552481432313 0.000335528271526932 yes 82 1.42253992021922e-05 113 3889043 YPR107C YTH1
SGTC_738 1315-0003 72.4 µM 4.12574660947511 0.000400095906316264 yes 83 1.84766980913596e-05 17 6251474
SGTC_815 1582-0027 36.9 µM 4.10673422766805 0.000422935051314132 yes 84 2.00646255923706e-05 21 3128206
SGTC_474 dl-dihydrosphingosine 5 µM 4.07071174414598 0.000469557345390213 yes 85 2.34348583734278e-05 22 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1954 st077032 68.9 µM 4.05298235117076 0.000494212149706443 yes 86 2.52844093322478e-05 19 698907
SGTC_697 0508-1955 564 µM 4.0257717057379 0.000534392243447423 yes 87 2.83943824904911e-05 31 6243113
SGTC_206 4546-0025 72.014 µM 4.01220610511642 0.000555533312141287 yes 88 3.00769724299517e-05 69 6620745 YIL048W NEO1
SGTC_975 1335-0046 28.5 µM 3.94062974737691 0.000680460458455495 yes 89 4.06339899091442e-05 35 16486740
SGTC_2800 7887935 81.82 µM 3.92052039037229 0.000719957416839366 yes 90 4.41789795458042e-05 36 2961002
SGTC_1023 4482-3888 16 µM 3.90921645475069 0.000743076870100515 yes 91 4.62979844331669e-05 19 3303168
SGTC_2688 kanamycin b 96.69 µM 3.90909216808842 0.000743334827922105 yes 92 4.63218077245053e-05 377 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_792 4534-1957 155 µM 3.90302793455457 0.000756021873600355 yes 93 4.74983668564282e-05 32 1717904
SGTC_2189 6047310 154.431 µM 3.88800227468105 0.000788321472547872 yes 94 5.05363398645127e-05 19 711535
SGTC_2758 dehydroepiandrosterone 69.35 µM 3.8869060580339 0.000790726961602885 yes 95 5.07650116269115e-05 39 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2177 5811945 192 µM 3.87613379136095 0.000814727228345015 yes 96 5.3064671483073e-05 30 5343475
SGTC_482 fipronil 114 µM 3.86163050643482 0.000848099488052826 yes 97 5.63164100401384e-05 3 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1547 harmine 94.2 µM 3.83648347972348 0.000908957915553645 yes 98 6.24042937735508e-05 47 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 3.82101734010737 0.00094835470668016 yes 99 6.64511531671864e-05 14 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_352 k048-0007 5.11 µM 3.8193580723013 0.000952673209981083 yes 100 6.68997089065303e-05 83 6811911
SGTC_2435 5706476 10.6 µM 3.81924582421455 0.000952966004340661 yes 101 6.69301561221472e-05 30 5725375
SGTC_2176 5809774 33.9695 µM 3.79861757589596 0.00100819885114875 no 102 7.27527002056638e-05 14 2870539
SGTC_612 0302-0167 22.4 µM 3.76817231337146 0.00109509884992577 no 103 8.22235877369776e-05 40 235821
SGTC_2013 4024628 200 µM 3.67110920879578 0.00142000158040046 no 104 0.000120750057953287 55 5230760
SGTC_3152 9099253 49.47 µM 3.61534204374235 0.00164433381820161 no 105 0.000149975660767988 150 25236131
SGTC_3197 9113331 49.47 µM 3.60104308800543 0.00170683236648769 no 106 0.000158471519595167 44 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_550 4123-0385 25.7 µM 3.58950656750153 0.00175882457754843 no 107 0.000165652242317402 38 5731123
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 3.58441729257765 0.00178221544466456 no 108 0.000168915796943087 35 5355888
SGTC_1700 st030840 7.9285 µM 3.5684630739963 0.00185738860299774 no 109 0.000179540724344139 29 5499307
SGTC_3084 9116877 49.47 µM 3.55623764707021 0.00191693063347211 no 110 0.00018810189943581 12 27241325
SGTC_799 1310-0557 151 µM 3.53590808047062 0.00201979260825288 no 111 0.000203188032559476 38 5354492
SGTC_861 0443-0273 110 µM 3.5192485901455 0.00210779258274532 no 112 0.000216385496236982 20 6149169
SGTC_2141 5621638 7.665 µM 3.49694631955346 0.00223104251382696 no 113 0.000235308260849931 38 2856238
SGTC_2377 9073351 62.6 µM 3.4955652587128 0.0022388852707445 no 114 0.000236529379414875 33 7337946 YHR072W ERG7
SGTC_812 4251-0442 148 µM 3.47743271822071 0.00234419877075624 no 115 0.000253120043111318 18 5723007
SGTC_3110 9122132 49.47 µM 3.46124552079411 0.00244198091425297 no 116 0.000268841098431369 24 918317
SGTC_1586 deoxycorticosterone acetate 53.7 µM 3.44827716560662 0.0025229648755356 no 117 0.000282087389277865 26 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_943 3253-1379 105 µM 3.4416962437344 0.00256498284176949 no 118 0.000289039494317312 44 668464
SGTC_2472 5377652 49.4 µM 3.42895517197203 0.0026481342071984 no 119 0.000302954797981778 81 1610903
SGTC_3003 9075612 71.4286 µM 3.42235386864648 0.00269216661575771 no 120 0.000310407293121661 35 6501993
SGTC_2906 7926292 26.41 µM 3.38146021594516 0.00297998209905251 no 121 0.000360508364001061 41 2966319
SGTC_2267 7931562 200 µM 3.37966887175855 0.00299320136053422 no 122 0.000362866039328388 39 934880
SGTC_576 1073-0113 22.7 µM 3.37396237601955 0.00303566555528806 no 123 0.00037047247061356 91 5439563
SGTC_2031 5180455 200 µM 3.36708640763254 0.00308755263824899 no 124 0.000379834408490743 24 29949
SGTC_2900 5328528 85.29 µM 3.33357614628704 0.00335203382142311 no 125 0.000428685999390924 51 795359
SGTC_328 k915-0120 63.5 µM 3.32992477023872 0.00338204936441335 no 126 0.000434347256065478 35 6624543
SGTC_256 clotrimazole 625 nM 3.32730483855696 0.00340373469757736 no 127 0.00043845194356134 51 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 3.32084514643087 0.00345773673644263 no 128 0.000448726582279386 37 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2647 atorvastatin 60.16 µM 3.31408701885594 0.00351505629500983 no 129 0.000459714442503598 33 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_819 1013-0258 27.7 µM 3.30924663457214 0.00355663329228873 no 130 0.000467736957837476 59 5753198
SGTC_1715 st032160 10.2275 µM 3.28982860729917 0.00372790025069256 no 131 0.000501242125632411 70 5289825
SGTC_2145 5634607 200 µM 3.2699867873968 0.00391050992057045 no 132 0.00053776253919648 21 308662
SGTC_1752 st044819 83.042 µM 3.26249358860086 0.00398153016027294 no 133 0.00055218335440919 44 441209 YML126C ERG13
SGTC_3002 9075603 71.4286 µM 3.25003669127498 0.00410215536086105 no 134 0.000576950598469244 51 20105405
SGTC_2897 9048598 12.99 µM 3.24040782204814 0.00419762567927579 no 135 0.000596794279412231 38 6467404
SGTC_358 0075-0058 9.45 µM 3.23858935713867 0.00421587727261041 no 136 0.00060061192993423 108 1069125
SGTC_1055 3448-0672 86 µM 3.22416594106692 0.00436317467378212 no 137 0.000631700829634438 71 748378
SGTC_2701 st077767 14.721 µM 3.19668192808252 0.00465663721072794 no 138 0.00069509064500408 83 5721188
SGTC_768 0384-0033 77.3 µM 3.19452846825013 0.00468035841917326 no 139 0.000700297354114721 128 3965305 YMR134W ERG29
SGTC_1424 4048-1941 275 µM 3.18181530719628 0.00482260843222905 no 140 0.000731775585145909 58 X1424
SGTC_366 0181-0206 4.31 µM 3.17848720228121 0.00486047816962995 no 141 0.000740228767645301 79 274874
SGTC_346 4513-0042 7.16 µM 3.13322278237542 0.00540249075081863 no 142 0.000864490779142459 73 2827372
SGTC_367 0335-0881 7.1 µM 3.13266648481057 0.00540947364416589 no 143 0.000866130775271578 129 23828853
SGTC_801 0866-0028 10.1 µM 3.12725764757498 0.00547778711839561 no 144 0.000882226124167826 83 6849771
SGTC_1643 st009866 20.2 µM 3.1237283880635 0.00552277384585313 no 145 0.000892876083496161 49 3156273 YOR207C RET1
SGTC_3314 9135860 59.4275 µM 3.10945083703231 0.00570813457948242 no 146 0.000937177373207504 51 25252478
SGTC_847 0342-0274 5.54 µM 3.09654477596874 0.00588042033935835 no 147 0.000978951450497602 52 18097
SGTC_345 1362-0200 395 µM 3.09543324150672 0.00589547198588645 no 148 0.000982628036759914 51 1419823
SGTC_1101 ebselen 5.29 µM 3.09288531381715 0.00593010329881195 no 149 0.00099110361267225 54 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_7 0192-1582 4.227 µM 3.07310730102866 0.00620511689141277 no 150 0.00105921150484225 125 252616
SGTC_1883 5-benzylidenerhodanine 20 µM 3.07101850127167 0.00623481113250053 no 151 0.00106664965860168 131 1273210
SGTC_2443 5493264 126.67 µM 3.06900398669278 0.00626356847563919 no 152 0.00107386862593397 55 5340055
SGTC_858 0438-0351 2.77 µM 3.06795451897446 0.00627859618325627 no 153 0.00107764709066054 62 2799119
SGTC_1085 doxorubicin 7.67 µM 3.06127989273088 0.00637492189384782 no 154 0.00110196483304938 54 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.056757068728 0.00644093478765386 no 155 0.00111872765432274 107 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2867 9039098 71.43 µM 3.05361500851655 0.00648715006568364 no 156 0.0011305101853347 83 6463460
SGTC_1307 1187-1599 12.2 µM 3.03419548367436 0.00677934739641117 no 157 0.00120589049055782 39 1538471
SGTC_2896 9052656 71.43 µM 3.02050046086761 0.00699234357413565 no 158 0.00126178662049102 206 6469436
SGTC_3317 9138495 8.753 µM 3.01855019545494 0.00702315132488504 no 159 0.00126993661212642 64 17020139
SGTC_2246 7293507 91.5585 µM 3.01242703286368 0.0071206569973849 no 160 0.00129583866751645 78 887656
SGTC_2144 5628481 200 µM 3.00150375535751 0.00729756874303878 no 161 0.00134324862823692 65 2818399
SGTC_1119 parthenolide 318.541 nM 2.99753357761214 0.00736282282894411 no 162 0.00136086937054791 96 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1357 1503-1303 39.5 µM 2.98695125489589 0.00753927329117645 no 163 0.00140887323220277 96 292895
SGTC_1284 0929-0043 16 µM 2.98158157032237 0.00763022413596922 no 164 0.00143381820725604 70 1239883
SGTC_3336 9143619 71.43 µM 2.96830611009801 0.00785924006314857 no 165 0.00149722976857435 54 45595730
SGTC_2363 9053361 176 µM 2.96711294900949 0.00788011652828324 no 166 0.00150305252315307 79 6469797 YMR079W SEC14
SGTC_2697 mebhydrolin 72.4 µM 2.95753053083817 0.00804955425298782 no 167 0.00155057018294178 132 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_921 1561-0023 372 µM 2.94745365140616 0.00823118169329435 no 168 0.00160201389587596 61 24050882
SGTC_2269 7935389 174.42 µM 2.92642684889603 0.00862180181060593 no 169 0.00171440065561622 60 97605
SGTC_3029 9088683 49.47 µM 2.92623813775782 0.00862537992991099 no 170 0.00171544101688215 65 25236615
SGTC_2366 9070441 60.58 µM 2.91346088058341 0.00887069702159211 no 171 0.00178723309704672 87 6837235
SGTC_397 arbidol 50 µM 2.91165036087997 0.00890594811665249 no 172 0.00179762411296636 69 131410 A RNA synthesis inhibitor.
SGTC_3188 9110789 49.47 µM 2.88369169679837 0.00946609851647437 no 173 0.00196521671912493 79 849217
SGTC_1834 st055981 52.8 µM 2.88278062214958 0.00948485893200478 no 174 0.00197090928550333 84 471719 YDL150W RPC53
SGTC_2233 sulbentine 40.3845 µM 2.87823127340747 0.00957902423673876 no 175 0.00199955918313755 131 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1301 naphtanilide LB 4.81 µM 2.87588953735634 0.00962781279585952 no 176 0.00201445339507605 49 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2090 5301565 104.445 µM 2.8726338852214 0.00969600300007896 no 177 0.00203532777079148 101 2056344
SGTC_1982 st072467 71.9 µM 2.86983301628383 0.00975500500384329 no 178 0.00205344309195127 102 3163533
SGTC_818 4072-2707 53.5 µM 2.86512060954175 0.00985498265625682 no 179 0.00208425220595273 56 882871
SGTC_1142 3253-1408 9.78 µM 2.85830967569682 0.0100010632445748 no 180 0.00212952259260227 50 256655
SGTC_489 paxilline 115 µM 2.85166387115288 0.0101454204274089 no 181 0.00217455313264366 68 105008 A toxic potassium channel blocker.
SGTC_1098 clofazimine 15.1 µM 2.84684960568985 0.0102511260002621 no 182 0.00220771083774556 95 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1496 4469-0713 57.4 µM 2.84262439012467 0.0103446880768498 no 183 0.00223718835980389 69 746691
SGTC_1243 0416-0003 5.65 µM 2.84193543525842 0.0103600145010166 no 184 0.0022420285780817 93 2141977
SGTC_2225 6654152 15.4 µM 2.8262768595127 0.0107137312924039 no 185 0.00235462708965711 46 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_485 niflumic acid 177 µM 2.82348095937184 0.0107779833045394 no 186 0.00237526237933825 44 4488 A COX2 inhibitor.
SGTC_2092 5303694 80.6725 µM 2.81346693951522 0.0110108738185167 no 187 0.00245052127820947 97 1963699
SGTC_1937 st074714 47.2 µM 2.79695740277175 0.011404389312827 no 188 0.00257931670310063 101 17250970
SGTC_869 0564-0080 44.1 µM 2.78882910091307 0.0116025819988628 no 189 0.00264494855570822 95 6843321
SGTC_3073 9114972 49.47 µM 2.78266827403824 0.011754787578614 no 190 0.00269569494984056 60 41905075
SGTC_1875 nocodazole 6 µM 2.76957654586766 0.0120839869104911 no 191 0.00280646067835492 100 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2065 5221596 34.26 µM 2.7675832105281 0.0121348052741278 no 192 0.00282368133901297 73 788581
SGTC_526 4469-0568 170 µM 2.76406352166992 0.0122249891277391 no 193 0.00285432124648847 89 2901964
SGTC_2882 9058044 58.44 µM 2.75815894059461 0.012377584998054 no 194 0.00290639636461667 70 18076804
SGTC_2157 5649910 96.377 µM 2.75701132858334 0.0124074342027557 no 195 0.00291661652719421 91 2858091
SGTC_575 k072-0246 11.9 µM 2.75107707081367 0.0125627799850917 no 196 0.00296998331712235 87 6796779
SGTC_2138 5575593 77.673 µM 2.73505485552523 0.0129906433461644 no 197 0.00311849406123461 58 762213
SGTC_1573 oleylamine 1.06 µM 2.7313309921357 0.0130918723059848 no 198 0.00315395424134288 105 5356789 An amine of the fatty acid oleic acid.
SGTC_1483 3453-0561 55.9 µM 2.72095146193288 0.0133776341875023 no 199 0.00325471593293156 90 4546991
SGTC_2871 9038510 12.99 µM 2.71411963498577 0.0135686490259929 no 200 0.00332260816060414 82 4945164
SGTC_391 gliotoxin 8.33 µM 2.71270857308165 0.0136083936755389 no 201 0.00333678843352876 129 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1800 st050079 29.0735 µM 2.68584687183467 0.0143843782554968 no 202 0.00361731183121454 281 3645560
SGTC_2824 7998404 51.95 µM 2.68149788720577 0.0145135305073194 no 203 0.00366466886286738 102 837851
SGTC_3334 9142812 21.919 µM 2.68131829169725 0.0145188853655801 no 204 0.00366663642238518 97 45283678
SGTC_1726 st035556 14.5795 µM 2.66660453190491 0.0149634095691857 no 205 0.00383108871313149 133 5919439
SGTC_2852 9023854 51.95 µM 2.66347738649805 0.0150593782420181 no 206 0.00386688048936946 95 19798528
SGTC_1803 st050068 52.4 µM 2.65224629325037 0.0154084219585815 no 207 0.00399790965699077 317 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2984 9022109 38.96 µM 2.65112190889424 0.0154437454405659 no 208 0.00401124394047772 53 6459207
SGTC_1480 1070-0044 41.2 µM 2.63907916693091 0.0158264584515487 no 209 0.00415657825489997 94 3124987
SGTC_2841 9004761 38.96 µM 2.62940257840292 0.0161398424183388 no 210 0.00427675179244064 104 2991039
SGTC_1115 galangin 695.678 nM 2.62724337821086 0.0162104909034405 no 211 0.00430398711967518 93 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1967 st070177 51.4 µM 2.62623214097533 0.0162436693188601 no 212 0.00431679570833759 91 5729214
SGTC_1727 st034309 9.9045 µM 2.61463323923384 0.016628404813304 no 213 0.00446616568693396 155 870305
SGTC_2997 9067075 71.4286 µM 2.61213566147742 0.0167122621608952 no 214 0.00449892707022466 153 27209819
SGTC_1949 st076024 69.1 µM 2.60555628489646 0.0169349016271868 no 215 0.00458626008420858 117 2921930
SGTC_1706 st031321 9.9705 µM 2.59774591087165 0.0172024843611469 no 216 0.00469189511461822 65 6103185
SGTC_1053 3366-3204 134 µM 2.5855242426929 0.0176284443288477 no 217 0.00486155174862624 117 3632071 YPR165W RHO1
SGTC_2326 6164455 177.58 µM 2.57783222410457 0.0179011229050348 no 218 0.0049711128838125 100 2888790
SGTC_1113 artemisinin 1.17947 µM 2.57173062172867 0.0181199728078021 no 219 0.00505957967243307 78 2240 An anti-malaria and mitochondrial poison.
SGTC_1732 st034308 51.822 µM 2.56977889240162 0.018190456355584 no 220 0.00508817214366306 111 830119
SGTC_2944 9067346 25.62 µM 2.56378285862999 0.0184084566906891 no 221 0.00517691485492364 128 6473075
SGTC_835 0312-0010 67.2 µM 2.54245890121342 0.0192018580306838 no 222 0.00550377728622329 83 1626196
SGTC_1430 4049-0248 69.1 µM 2.53475343102531 0.0194956180061196 no 223 0.00562632495319051 119 22774488
SGTC_2856 9022925 19.48 µM 2.52820064607039 0.0197484285921605 no 224 0.00573244050023574 129 4944862
SGTC_885 0865-0106 16.8 µM 2.52653868122495 0.0198129888780276 no 225 0.00575963512138041 128 2793380
SGTC_1654 st012436 41.8 µM 2.48868976496994 0.0213324747980196 no 226 0.00641073961782452 92 4323132
SGTC_2299 7976368 114.88 µM 2.48421885171208 0.0215183072710055 no 227 0.00649179934410068 106 2979718
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.47760739916305 0.0217956172816794 no 228 0.0066133297573667 180 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2192 5915882 198.485 µM 2.47152731876315 0.0220532979669102 no 229 0.00672686357554104 83 2876149
SGTC_1273 0849-0096 14.1 µM 2.46924657893986 0.0221506193037627 no 230 0.00676989419262221 118 5286025
SGTC_227 fluconazole 33.516 µM 2.46753058024348 0.0222240813215426 no 231 0.006802430008908 194 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_565 1418-0001 44.5 µM 2.46619083794872 0.0222815785863124 no 232 0.00682792784336211 129 2862145
SGTC_332 4112-0506 40.9 µM 2.46588792849734 0.022294595829094 no 233 0.00683370447231816 105 2790355
SGTC_1034 k072-0165 12.7 µM 2.46075874402337 0.0225159935527911 no 234 0.00693217802843668 129 5835461
SGTC_1818 st052136 56.3 µM 2.45085379414316 0.0229487825996496 no 235 0.00712589142237441 172 674169
SGTC_2322 7413319 38.22 µM 2.44281417619814 0.0233052001337815 no 236 0.00728661941729716 307 1840400
SGTC_1556 plumbagin 1.48 µM 2.44136769398254 0.023369818524414 no 237 0.00731587433427848 90 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1117 retinoic acid 1.10837 µM 2.43606766696544 0.0236078752462736 no 238 0.00742395333975301 109 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1227 3909-8010 46.6 µM 2.43110033469711 0.0238328368789588 no 239 0.00752652269342089 133 15982272
SGTC_2552 juarezic acid 87.02 µM 2.42801642861147 0.0239734061041119 no 240 0.00759082777946409 157 1549512
SGTC_611 3453-1652 23.7 µM 2.41833956427162 0.0244190233603647 no 241 0.00779575970835762 148 1560575
SGTC_313 3474-0040 5.03 µM 2.40887507771408 0.02486156647421 no 242 0.00800088708648309 216 1043375 YIL048W NEO1
SGTC_2778 tioconazole 65.09 nM 2.40166166908701 0.0252033525861518 no 243 0.00816039774585215 194 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2323 6148992 148.28 µM 2.38260232197986 0.0261254153594543 no 244 0.00859537690500474 134 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_852 0418-0143 439 µM 2.38041313104635 0.0262331089939007 no 245 0.00864661894002691 211 5369229
SGTC_844 0330-0132 15.3 µM 2.3773675621293 0.026383547853905 no 246 0.00871835163396385 101 2828079
SGTC_260 nsc-65238 3.989 µM 2.37717134455549 0.0263932648869299 no 247 0.00872299101315077 110 3246252
SGTC_3199 9111318 49.47 µM 2.3699498301236 0.026752972941095 no 248 0.00889524956727397 137 8548020
SGTC_163 TUB2.036 7.546 µM 2.36878786954714 0.0268112315316228 no 249 0.00892324303990246 304 15992207 YJR013W GPI14
SGTC_3098 9119039 49.47 µM 2.36476860535243 0.0270135676770128 no 250 0.00902066962102875 145 17161528
SGTC_3232 9132874 49.47 µM 2.36171262135497 0.0271682622723361 no 251 0.00909536864801531 107 3784940
SGTC_79 0052-0007 94.094 µM 2.34639053089346 0.027955054023797 no 252 0.00947811686137327 139 2801472
SGTC_2469 5655019 90.81 µM 2.33249716114542 0.028684799291864 no 253 0.00983727604395608 152 2788239
SGTC_644 1498-1197 63.3 µM 2.32309937621153 0.0291873428570572 no 254 0.0100869072448593 151 6741615
SGTC_1256 0570-0116 285 µM 2.31514782574155 0.0296182415830748 no 255 0.010302421720427 149 410638
SGTC_2190 6049624 200 µM 2.31483182515875 0.0296354743198391 no 256 0.0103110687563714 84 2265554
SGTC_984 1492-0255 2.91 µM 2.31463188311596 0.0296463822319543 no 257 0.0103165432360445 134 1585198
SGTC_592 k241-0073 46.5 µM 2.30429937301217 0.0302146277262922 no 258 0.0106029220689286 142 4230158
SGTC_559 1550-0661 158 µM 2.30361225319584 0.0302527344680233 no 259 0.0106222097005015 122 5830875
SGTC_1969 st069479 40.1 µM 2.28263492651663 0.0314354169272087 no 260 0.0112259409184413 119 3895485
SGTC_600 1495-0418 41.6 µM 2.2810881830089 0.031524113481161 no 261 0.0112716146278382 139 5377768
SGTC_64 000l-0018 272.079 µM 2.28062485628845 0.0315507227457758 no 262 0.0112853275791531 326 6811119
SGTC_1705 st027868 56.3335 µM 2.27897101463036 0.0316458557850001 no 263 0.0113343941895188 120 292948
SGTC_871 0574-0004 149 µM 2.27831801375315 0.0316834832192714 no 264 0.0113538185816547 196 9551173
SGTC_1903 st060211 78.3 µM 2.26860225827005 0.0322477079361418 no 265 0.0116462620831961 173 688960
SGTC_2221 6807166 181.081 µM 2.26236378405547 0.0326143490315418 no 266 0.0118374682824377 72 674925
SGTC_607 4491-0986 66.8 µM 2.26140363172604 0.0326710822088518 no 267 0.011867137041811 162 698981 YDR232W HEM1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 2.26001649397799 0.0327531886576127 no 268 0.0119101135880798 164 6710655
SGTC_3016 9080866 49.47 µM 2.25581078367656 0.0330031704422283 no 269 0.0120412418526956 175 17066299
SGTC_2928 9011484 9.79 µM 2.25466579730212 0.0330714985289555 no 270 0.0120771570249761 150 2994751
SGTC_2525 harmine 47.85 µM 2.24811324144995 0.0334647737850706 no 271 0.0122844849711703 103 5280953 A monoamine oxidase inhibitor
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.24545287840415 0.0336255402219706 no 272 0.012369537025864 135 756377
SGTC_2886 9058944 51.95 µM 2.24186736524154 0.0338432188314752 no 273 0.0124849728962392 56 4949929
SGTC_3013 9080133 71.4286 µM 2.2320322409613 0.0344462721081776 no 274 0.012806416065515 178 17050193
SGTC_2405 ticlatone 3.52 µM 2.22842013931969 0.0346699578182617 no 275 0.0129262556738682 230 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_46 0329-0187a 2.197 µM 2.22391757947453 0.0349504555946988 no 276 0.0130769950382184 249 46494817
SGTC_1445 4239-0156 97.7 µM 2.21863441551621 0.0352819552661093 no 277 0.0132558030991641 186 4008346
SGTC_2327 6189656 200 µM 2.21576874313328 0.0354628421142799 no 278 0.01335367208209 149 5349088
SGTC_524 r073-0010 27.8 µM 2.20946188850642 0.0358636221202788 no 279 0.0135712652272068 190 2772106
SGTC_2063 5246145 200 µM 2.2087777817542 0.0359073170853372 no 280 0.0135950505879217 195 711240
SGTC_2122 5258151 111.688 µM 2.2067730294727 0.0360356149615571 no 281 0.0136649601038647 178 2173356
SGTC_108 0509-0257 621.132 µM 2.20079455985104 0.0364204491152962 no 282 0.0138752854505156 230 536624
SGTC_1354 1498-1681 81 µM 2.20052569903283 0.036437834414103 no 283 0.0138848093351652 181 5754243
SGTC_164 4100-3994 89.624 µM 2.19728439663909 0.036647961119097 no 284 0.0140000706602405 215 4615967
SGTC_3078 9116413 49.47 µM 2.19668472921406 0.0366869447220948 no 285 0.0140214851149813 179 17177322
SGTC_2057 5236571 38.335 µM 2.18568055167574 0.0374083538164944 no 286 0.0144194923644821 228 54684039 YBR257W POP4
SGTC_458 nppb 133 µM 2.16972727722579 0.038474749124263 no 287 0.0150137561857275 143 4549 A chloride channel blocker.
SGTC_2432 5630864 12.22 µM 2.16936013561416 0.0384995793498675 no 288 0.015027676499238 201 5714970
SGTC_934 2950-0684 338 µM 2.1690194151467 0.0385226343647251 no 289 0.0150406049677536 183 1121253
SGTC_2277 7947813 106.88 µM 2.16453210915806 0.0388273212936134 no 290 0.0152117675303239 200 1246798
SGTC_2004 4023728 41.89 µM 2.15812856885663 0.0392655162338928 no 291 0.0154589185612059 204 360084 YDR527W RBA50
SGTC_3352 9151559 45.5865 µM 2.15394698674418 0.0395538283347895 no 292 0.0156221647831337 167 17159339
SGTC_1970 st070122 35.8 µM 2.15248454428999 0.0396550664282779 no 293 0.0156796056464887 187 102928
SGTC_2045 5106652 78.05 µM 2.15232975826775 0.0396657938651256 no 294 0.0156856958217476 152 673349
SGTC_2979 9012552 45.46 µM 2.15229120792246 0.0396684659617189 no 295 0.0156872129303925 122 17100905
SGTC_226 1,3-diallylurea 8.28947 mM 2.14990531025101 0.0398341282601302 no 296 0.015781352755829 152 74537 YKL182W FAS1
SGTC_602 3130-1533 38.1 µM 2.14822700626859 0.0399509961311594 no 297 0.0158478631503065 202 720941
SGTC_1634 st006576 41 µM 2.14680913515079 0.0400499459010665 no 298 0.0159042398896339 181 3915356
SGTC_1489 4065-0444 182 µM 2.14220245722101 0.0403728100376374 no 299 0.0160885969361855 163 2877968
SGTC_1382 3002-2117 298 µM 2.13381205193366 0.0409662896947506 no 300 0.0164290844775573 163 1497314
SGTC_1529 apigenin 74 µM 2.13283268191623 0.0410360224509304 no 301 0.0164692271120453 213 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3341 9147222 25.867 µM 2.12592555525755 0.0415305589855078 no 302 0.0167547293259781 170 1939759
SGTC_2297 7971671 152.32 µM 2.12575630035269 0.0415427376479123 no 303 0.0167617781975068 181 909016
SGTC_336 4111-0029 111 µM 2.12185290779007 0.0418244082887554 no 304 0.0169250460369746 150 3131175
SGTC_1766 st045414 44.774 µM 2.11909315146288 0.0420244852923712 no 305 0.0170412976952657 214 253960
SGTC_2088 5278280 127.392 µM 2.11597136597025 0.0422517418270347 no 306 0.0171736214806338 227 791502
SGTC_1170 0310-0127 64.8 µM 2.10936280089477 0.0427361059794816 no 307 0.0174566389123106 214 774975
SGTC_788 1182-0090 188 µM 2.08848747216351 0.0442956768860534 no 308 0.0183769421595923 303 5715185
SGTC_3186 9110464 49.47 µM 2.07637696638742 0.0452212602868845 no 309 0.0189295499350026 166 17018021
SGTC_653 0203-0016 55.2 µM 2.06293517905952 0.0462667446532626 no 310 0.0195593936058026 204 295302
SGTC_2399 5884133 200 µM 2.05835482738803 0.0466274003680489 no 311 0.0197780423311474 262 722445
SGTC_1371 2421-0008 32.7 µM 2.05216427840556 0.0471184236932483 no 312 0.0200768498900389 255 2827552
SGTC_1801 st050089 28.441 µM 2.04977493089386 0.0473090477356252 no 313 0.0201931995154134 336 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_309 k408-0051 1.48 µM 2.04863424780106 0.047400270044033 no 314 0.0202489465647306 300 3640463
SGTC_1303 1160-0052 261 µM 2.04863244904006 0.0474004140051396 no 315 0.0202490345760594 193 3562476
SGTC_3109 9122853 49.47 µM 2.04091301456039 0.048021461333239 no 316 0.020629736984287 167 1234709
SGTC_1157 4092-0394 27.6 µM 2.03844982008081 0.0482209962802347 no 317 0.0207524841257706 244 3659885
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 2.03576487577847 0.0484392494186068 no 318 0.0208869855115438 208 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1440 4100-1550 40 µM 2.03310669803193 0.0486561042782316 no 319 0.021020872224241 131 742806
SGTC_2104 5389443 200 µM 2.03137709200236 0.0487976222980349 no 320 0.0211083782126511 234 2244536
SGTC_2650 prasterone 100 µM 2.03073408825057 0.0488503172845793 no 321 0.0211409882023716 115 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1941 st076221 61.8 µM 2.02714761082317 0.0491450684100288 no 322 0.0213236595152563 301 2828568
SGTC_1087 pterostilbene 9.05 µM 2.02234689746076 0.0495418315659942 no 323 0.0215702634446139 225 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1813 st051246 8.6015 µM 2.02163523740212 0.0496008648977612 no 324 0.0216070244609594 164 5291959
SGTC_106 0092-0003 11.579 µM 2.02129436856794 0.0496291603846687 no 325 0.0216246508870731 149 1072148
SGTC_2930 9013230 14.89 µM 2.02109766247401 0.0496454947975559 no 326 0.0216348281439309 260 2995857
SGTC_2078 5212016 200 µM 2.01890519681706 0.0498278469813319 no 327 0.021748536996431 167 1899708
SGTC_2437 5741531 144.16 µM 2.01626837449661 0.0500478645273303 no 328 0.0218859600214348 224 2262990
SGTC_914 3820-6779 408 µM 2.01428281713353 0.0502140509742255 no 329 0.0219899244749179 214 2893481
SGTC_3189 9110682 49.47 µM 2.01309292888472 0.0503138523973829 no 330 0.0220524269961222 207 17122418
SGTC_1501 4491-0275 38.4 µM 2.01195960798055 0.0504090561833637 no 331 0.0221120975160232 181 5104718
SGTC_292 k038-0015 474 µM 2.00111410197197 0.0513274012953477 no 332 0.0226900474834349 204 46368540
SGTC_3004 9076122 71.4286 µM 1.99379887713355 0.0519542997092379 no 333 0.0230870191736803 225 44782551
SGTC_173 1273-0061 2.693 µM 1.9850122579846 0.0527153188721176 no 334 0.0235715538582938 365 2847414 YPL266W DIM1
SGTC_1502 4534-4282 27.7 µM 1.98143885546183 0.0530273342084631 no 335 0.0237710399925541 191 3278949
SGTC_2180 6301957 200 µM 1.98134477302871 0.0530355688575779 no 336 0.023776311287503 160 845462
SGTC_1678 st019265 80.2 µM 1.97878116568965 0.0532603414061865 no 337 0.0239203249606791 257 5367020
SGTC_1534 6-azauridine 81.6 µM 1.97658144759895 0.0534538101511769 no 338 0.0240444804677237 262 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2034 5197015 53.07 µM 1.97448158697106 0.0536390153985072 no 339 0.0241635045525396 219 780676
SGTC_1234 0326-0494 15.5 µM 1.97361073871259 0.053715972151525 no 340 0.0242130108646188 199 1547813
SGTC_1361 1608-0041 5.61 µM 1.96656250163695 0.0543420463507573 no 341 0.0246168350463509 222 X1361
SGTC_1472 k841-0093 193 µM 1.96626106726058 0.0543689500634899 no 342 0.0246342308004645 252 X1472
SGTC_2925 9010536 32.5 µM 1.95937449078105 0.0549864677416777 no 343 0.0250344729128337 311 2994177
SGTC_2849 9019321 12.99 µM 1.95694374959478 0.0552057503920306 no 344 0.0251770410583212 256 16489627
SGTC_2329 6138490 200 µM 1.9557979679513 0.0553093531957937 no 345 0.0252444791821921 223 720019
SGTC_1929 genistein trimethyl ether 50.5 µM 1.95431960339385 0.0554432553023994 no 346 0.0253317159615048 228 136420
SGTC_3204 9114183 49.47 µM 1.94898923226893 0.0559281770853663 no 347 0.0256483553191144 241 17027248
SGTC_3244 9134489 49.47 µM 1.94464058196181 0.0563262614017849 no 348 0.0259091257188502 235 16584271
SGTC_1302 1159-0335 255 µM 1.94425342501692 0.0563618105439023 no 349 0.0259324490585405 210 649284
SGTC_1652 st011932 78 µM 1.94383938720079 0.0563998474817047 no 350 0.0259574112062303 202 1551076
SGTC_1793 st048256 72.231 µM 1.93634063832639 0.0570922520082164 no 351 0.0264129973339164 179 672022
SGTC_2816 7982706 58.44 µM 1.93227529329332 0.0574704172375225 no 352 0.0266627681092934 287 2981853
SGTC_774 k060-0086 136 µM 1.92808101460538 0.0578626384773637 no 353 0.0269225250291585 262 5911235
SGTC_3270 9137563 49.47 µM 1.92660934446759 0.0580007569799764 no 354 0.0270141666160696 201 17015724
SGTC_2620 irigenin 100 µM 1.92554073253044 0.0581012101320843 no 355 0.0270808726157467 271 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_880 0833-0487 87.2 µM 1.91783462248689 0.0588296634492864 no 356 0.0275659920759238 237 76075
SGTC_195 4234-0266 16.654 µM 1.91700171724041 0.0589088247172644 no 357 0.0276188567437683 294 2303354
SGTC_2067 5224629 34.075 µM 1.90896658464074 0.0596768014073554 no 358 0.0281332012163607 262 2835000
SGTC_657 3534-0529 86.7 µM 1.90639343263166 0.0599243879475901 no 359 0.028299590075908 240 1049549
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.90495150571372 0.0600634802668339 no 360 0.0283931875643663 115 4000243
SGTC_1287 0971-0001 34.6 µM 1.90302123944277 0.0602500747410292 no 361 0.0285188869285613 286 4665869
SGTC_1510 1123-0200 71.5 µM 1.90216205768336 0.0603332756951001 no 362 0.0285749857357785 322 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1255 0566-0045 221 µM 1.9005770929494 0.0604869955236554 no 363 0.0286787141462646 271 2788469
SGTC_2175 5807670 165.306 µM 1.90033858914858 0.060510153621975 no 364 0.0286943501582857 231 241186
SGTC_2200 6600604 21.907 µM 1.90015504603133 0.0605279799038529 no 365 0.0287063878427109 285 2904777
SGTC_910 3454-3003 490 µM 1.89580625524101 0.0609515511831278 no 366 0.0289928342184765 284 820824
SGTC_542 3381-0244 89.3 µM 1.88480744435686 0.0620331758314656 no 367 0.0297279197697134 282 1112843
SGTC_561 1550-0330 72.9 µM 1.88343975125367 0.0621687154709102 no 368 0.0298203987642718 231 6812934
SGTC_905 2-aminofluorene 215 µM 1.88282802937307 0.0622294123921901 no 369 0.0298618385993362 277 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3227 9130768 49.47 µM 1.8801718916509 0.0624934987598159 no 370 0.0300423275435936 188 17720899
SGTC_301 4119-0100 24.5 µM 1.87931983268046 0.0625783995339621 no 371 0.0301004176305439 321 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.87127275618483 0.0633846661813077 no 372 0.0306536423578831 323 688788
SGTC_3294 9122953 26.2835 µM 1.87026576690665 0.0634861268915188 no 373 0.0307234604379392 261 16459826
SGTC_2602 kawain 100 µM 1.87014440554231 0.0634983633671216 no 374 0.0307318837281487 294 5369129
SGTC_1449 4112-4002 201 µM 1.86745792068227 0.0637697032761614 no 375 0.0309188339143211 248 2059539
SGTC_1655 st012546 55.1 µM 1.86015709448622 0.06451165691384 no 376 0.0314316516784497 248 720985 YLR208W SEC13
SGTC_2035 5154463 94.595 µM 1.85566877208773 0.0649711050227906 no 377 0.0317503922674291 291 2769623
SGTC_722 3534-0461 190 µM 1.85444334259506 0.0650969867546245 no 378 0.0318378794064023 280 658262
SGTC_1399 3562-5772 25 µM 1.85210334613827 0.0653378876177319 no 379 0.0320054920579801 213 23847490
SGTC_2032 5185112 25.99 µM 1.84812199365191 0.0657493534223638 no 380 0.0322923483835482 229 5718189
SGTC_3035 9091303 49.47 µM 1.84688956845019 0.0658771286948833 no 381 0.0323815734514004 193 25237002
SGTC_886 0866-0150 153 µM 1.84495770583001 0.0660778073295953 no 382 0.0325218456357057 299 271463
SGTC_823 0417-1665 178 µM 1.84201906159401 0.066383976461608 no 383 0.0327361808537972 278 3429856
SGTC_3001 9076041 71.4286 µM 1.84176221453595 0.0664107887520995 no 384 0.0327549696682149 242 16004211
SGTC_687 k029-0044 34.9 µM 1.84147051987262 0.0664412489551961 no 385 0.0327763184277151 247 5829338
SGTC_2466 5983409 37.09 µM 1.84105931708519 0.0664842071596599 no 386 0.0328064333174949 251 2879657
SGTC_767 0929-0023 86 µM 1.83935442921759 0.0666625455941173 no 387 0.0329315361061415 389 1204563
SGTC_2188 6126565 140.678 µM 1.83835076405615 0.0667677061849052 no 388 0.0330053676357435 204 874518
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.82491113961351 0.0681882616202646 no 389 0.0340072199580219 265 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1948 st076329 66.6 µM 1.8223293995232 0.068463800920406 no 390 0.0342025099462589 257 24208413
SGTC_2865 9030313 51.95 µM 1.80806478334589 0.0700017187427626 no 391 0.0352982092149615 233 42562754
SGTC_1562 morin hydrate 59.1 µM 1.79720950349863 0.0711897695784683 no 392 0.0361511831912044 277 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_589 1227-0070 34.1 µM 1.78807178701563 0.0722017919659866 no 393 0.0368822133544338 280 2841384
SGTC_81 0411-0046 9.971 µM 1.78645645560944 0.0723818348240475 no 394 0.0370126908292867 257 12925265
SGTC_1191 1487-1166 10.6 µM 1.78188202948708 0.0728935611994131 no 395 0.0373842358189064 357 3955771
SGTC_2056 5235370 200 µM 1.77454938583758 0.073719612028046 no 396 0.0379861603961109 315 5511916
SGTC_232 clozapine 119 µM 1.7664732920815 0.0746376753421903 no 397 0.0386582392367557 322 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1316 1272-0050 65.9 µM 1.76226011291293 0.0751200659340435 no 398 0.0390126798777993 259 7340392
SGTC_631 k072-0230 41.5 µM 1.74933679624627 0.0766145626029416 no 399 0.0401164095188059 324 5773147
SGTC_1075 aripiprazole 15.2 µM 1.74859415493608 0.0767011263868083 no 400 0.0401805986927311 367 60795 An atypical antipschotic. YIL048W NEO1
SGTC_114 0364-0001 490.298 µM 1.74404631040136 0.077232855524052 no 401 0.0405755074431809 339 4003655
SGTC_2847 9005661 71.43 µM 1.73684542447833 0.0780804965810662 no 402 0.0412072293550068 175 2991449
SGTC_2761 levamisole 97.89 µM 1.73327537474444 0.0785033475085577 no 403 0.0415233677400351 295 26879 An alkaline phosphatase inhibitor.
SGTC_184 1494-0393 24.714 µM 1.7329248397167 0.0785449596879314 no 404 0.0415545143099536 357 3090647
SGTC_210 3551-0445 56.827 µM 1.73260208707737 0.0785832885892838 no 405 0.0415832090282047 336 2865180 YOR207C RET1
SGTC_1132 3456-3614 2.5 µM 1.73212565677453 0.0786398935846276 no 406 0.041625595982652 404 3125502
SGTC_2723 salbutamol 83.58 µM 1.72957177276167 0.078943849124814 no 407 0.0418534064487341 186 9884233 β2-adrenoceptor agonist
SGTC_690 glyoxal 20.3 µM 1.72026884008358 0.0800585835702695 no 408 0.042691792376933 380 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1041 0206-0046 107 µM 1.72001857195342 0.0800887357685873 no 409 0.0427145328695478 305 50494
SGTC_1140 3229-1848 2.98 µM 1.71718309675149 0.0804309524848375 no 410 0.0429728614982812 260 2849525
SGTC_694 1315-0438 43.2 µM 1.71556783331592 0.080626393774194 no 411 0.0431205850525006 269 6793154
SGTC_102 gallobenzophenone 83.616 µM 1.71136771591038 0.0811362722014112 no 412 0.043506626499781 354 70837
SGTC_1608 st001473 40.5 µM 1.70941559899448 0.0813740784627398 no 413 0.0436869967388646 332 7292267
SGTC_2102 5377816 72.7585 µM 1.70818575015144 0.0815241679728617 no 414 0.0438009408715443 322 1379702
SGTC_12 0849-0099 9.267 µM 1.70357651945734 0.0820885314236694 no 415 0.0442301156216787 296 6071388
SGTC_662 k832-1615 104 µM 1.70330680662307 0.082121646530276 no 416 0.0442553337355095 312 5878478
SGTC_2670 beta-carotene 100 µM 1.6979905122509 0.082776432291827 no 417 0.0447547762756533 220 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1286 0929-0070 131 µM 1.68928947030468 0.0838565680899128 no 418 0.0455819851336175 354 1420408
SGTC_43 0570-0105 72.5 µM 1.68815078798509 0.08399870232684 no 419 0.0456911436104716 485 1114046 YDL195W SEC31
SGTC_445 e6 berbamine 66 µM 1.68472038410533 0.0844279904457439 no 420 0.0460212659001055 481 6610268 A calcium/calmodulin antagonist.
SGTC_740 k014-0057 261 µM 1.67973045732294 0.0850553764231613 no 421 0.0465048855246189 369 4012779
SGTC_1130 3454-2858 15.9 µM 1.67683247992666 0.0854213409259536 no 422 0.0467876222262393 378 715628 YIL048W NEO1
SGTC_1540 guanosine 70.6 µM 1.67323659830349 0.0858770767558512 no 423 0.0471403641029728 285 6802 Guanosine is a purine nucleoside
SGTC_1013 4112-3890 241 µM 1.65605115515807 0.0880802847137983 no 424 0.0488557298799599 364 705171
SGTC_22 0964-0034 14.468 µM 1.64865247476086 0.0890416823605349 no 425 0.0496094258708904 393 138402
SGTC_1181 1222-0449 220 µM 1.64548653140467 0.0894554485427662 no 426 0.0499347589632794 344 658318
SGTC_2146 5545642 200 µM 1.64080577332236 0.0900698078630802 no 427 0.0504188697306954 316 825326
SGTC_1263 0774-1208 64.8 µM 1.63545227904988 0.0907763019190698 no 428 0.0509771353590788 429 906585
SGTC_1491 4138-0063 26.5 µM 1.63367209947978 0.0910121387518545 no 429 0.0511638598897065 298 23883227
SGTC_2810 7959871 45.46 µM 1.62879768127695 0.0916602235079596 no 430 0.0516779278682128 429 2974535
SGTC_2183 6420625 130.508 µM 1.62674375915063 0.0919343270732173 no 431 0.0518957653905554 437 2897619
SGTC_2413 inermin 26.06 µM 1.61834898801888 0.0930609527925163 no 432 0.0527937044471403 408 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_286 k060-0067 22.9 µM 1.61643667561798 0.0933190170500591 no 433 0.052999967105392 355 5985051
SGTC_2021 4019055 173 µM 1.61496118701937 0.0935184935174759 no 434 0.0531595501690202 559 44827708 YER133W GLC7
SGTC_2597 laccaic acid a 100 µM 1.61330230015146 0.0937431400950951 no 435 0.0533394235389588 405 5491415 A textile dye.
SGTC_2741 miltefosine 3.04 µM 1.61032851633955 0.0941468468825392 no 436 0.0536630785061041 291 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1511 0906-3109 28.5 µM 1.60728834090949 0.0945608910693588 no 437 0.0539955653521128 488 2882180
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.60614456295716 0.094717010218797 no 438 0.0541210752634231 347 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3243 9134147 49.47 µM 1.60522807690982 0.0948422423480201 no 439 0.0542218103419927 319 24282180
SGTC_2990 9074105 71.4286 µM 1.60353719159723 0.0950736114474013 no 440 0.0544080524270685 325 6502001
SGTC_2805 7950783 58.44 µM 1.60353360454949 0.0950741027158078 no 441 0.0544084480586257 431 1178958 YDL195W SEC31
SGTC_387 norethindrone acetate 66.7 µM 1.60294824276122 0.0951542966885686 no 442 0.0544730407234761 326 541197
SGTC_1828 st055811 49 µM 1.59548287963299 0.0961814161497555 no 443 0.0553021477341208 321 5877589
SGTC_2436 5633522 8.09 µM 1.59306968774898 0.0965151712168336 no 444 0.0555722792644946 390 5724242
SGTC_3252 9135871 49.47 µM 1.58756787024365 0.0972792766669496 no 445 0.0561920441927177 367 17682838
SGTC_3103 9120822 49.47 µM 1.57048694114381 0.0996797834313661 no 446 0.0581509350619136 394 17141819
SGTC_2252 omeprazole 400 µM 1.55950441508889 0.101245928419191 no 447 0.0594385202063608 272 4594 A proton pump inhibitor.
SGTC_2721 ifenprodil 61.44 µM 1.5575315136338 0.101529160216512 no 448 0.0596721722776357 379 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1579 chlormadinone acetate 49.4 µM 1.55553265059042 0.101816707123872 no 449 0.0599096323426246 394 45114258 A steroidal progestin.
SGTC_1494 4358-1428 177 µM 1.55383945060822 0.102060746181851 no 450 0.060111358833884 408 1564571
SGTC_1039 k821-0043 94 µM 1.55225667353505 0.10228925471718 no 451 0.060300410188756 389 15992768
SGTC_264 promethazine 12.5 mM 1.55117309971594 0.102445906757933 no 452 0.0604301034248885 514 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_500 h-89 112 µM 1.55041924050729 0.102554994875417 no 453 0.060520461712808 412 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_504 lovastatin 124 µM 1.54698909144658 0.103052425133408 no 454 0.0609329380553389 322 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1134 3477-0009 42.5 µM 1.54580590670004 0.103224412995442 no 455 0.0610757250475785 445 3973534
SGTC_2012 4023501 200 µM 1.54509653253807 0.103327627587922 no 456 0.0611614577958179 381 3477460
SGTC_1002 4049-0206 172 µM 1.54406530362406 0.103477805942135 no 457 0.0612862566047866 448 4662749
SGTC_1722 st034304 3.6505 µM 1.54296075529605 0.103638837487038 no 458 0.0614201490832694 418 4036148 YLR033W RSC58
SGTC_2311 7694451 200 µM 1.54225012167967 0.103742536483545 no 459 0.0615064122511988 410 2163142
SGTC_588 3970-1144 52.9 µM 1.54218197309233 0.10375248499966 no 460 0.0615146897159153 414 1888707
SGTC_1856 st057054 55.7 µM 1.52721887540477 0.105953628164775 no 461 0.0633532971022541 411 1266018
SGTC_1912 st060209 90.8 µM 1.52502664291197 0.106278929416759 no 462 0.0636262262151096 412 688787
SGTC_528 3492-0019 172 µM 1.52179553481706 0.106759701583606 no 463 0.0640301603326729 658 2869262
SGTC_3304 9125678 46.087 µM 1.52045502333188 0.106959622704315 no 464 0.0641983272485954 449 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.51940614094024 0.107116239085631 no 465 0.0643301485893886 425 5393153
SGTC_3169 9102970 49.47 µM 1.51646352286233 0.107556505812137 no 466 0.0647010935981001 354 17027839
SGTC_1882 5615643 20 µM 1.51642363017143 0.107562483396584 no 467 0.0647061338397541 359 2253075
SGTC_3161 9100388 49.47 µM 1.5117390136143 0.108266099357573 no 468 0.0653001347611184 385 25236368
SGTC_2770 toltrazuril 17.5 µM 1.51112983221135 0.108357839488746 no 469 0.0653776876835058 427 68591 Kills coccidiodes.
SGTC_1094 duloxetine 25.4 µM 1.50908284682686 0.108666516552562 no 470 0.0656388062436694 424 60834 A selective serotonin reuptake inhibitor.
SGTC_2191 5911152 200 µM 1.5070499134221 0.108973700050839 no 471 0.0658989318560162 401 2875902
SGTC_2172 5754775 163.918 µM 1.50183659646249 0.109764302406491 no 472 0.0665696571991471 408 2263357
SGTC_2858 9025781 8.96 µM 1.50025371518374 0.110005160041953 no 473 0.0667743469407567 558 4894980 YPL153C RAD53
SGTC_2108 5365811 200 µM 1.49176175276672 0.111303806898368 no 474 0.0678808069462797 429 780283
SGTC_507 nimesulide 162 µM 1.49142899033728 0.111354917633145 no 475 0.0679244507756618 428 4495 A COX2 inhibitor.
SGTC_2994 9053520 71.4286 µM 1.48852303261409 0.111801973044226 no 476 0.0683065062942259 432 4647384
SGTC_610 4215-0184 155 µM 1.48108727230497 0.112951738675548 no 477 0.0692916595178991 453 5605015
SGTC_2223 6903751 107.57 µM 1.48006111727598 0.113111069777602 no 478 0.0694284684998623 361 5598863
SGTC_1899 st063254 59.6 µM 1.47810298105721 0.113415554485062 no 479 0.069690108154602 370 3093813
SGTC_518 1021-0119 62.6 µM 1.47583091706176 0.113769586187023 no 480 0.0699946443605602 449 1097762
SGTC_2219 9098279 200 µM 1.47513387993262 0.113878355832212 no 481 0.0700882767173319 423 902349
SGTC_3246 9135460 32.98 µM 1.47102662338262 0.114520780434728 no 482 0.0706419585174821 349 41446951
SGTC_2110 5483698 200 µM 1.4695733946513 0.114748699642771 no 483 0.0708386651771884 421 2848765 YHR062C RPP1
SGTC_1282 0886-0010 32.4 µM 1.46117785717092 0.116071744532797 no 484 0.0719833190378141 480 2836211 YNL267W PIK1
SGTC_1484 3473-2379 286 µM 1.45977252425173 0.116294263350566 no 485 0.0721763010870707 533 671917
SGTC_2345 9052315 157.45 µM 1.45751189193933 0.116652844058613 no 486 0.0724875655763735 437 6469265
SGTC_1745 st081495 74 µM 1.45719307355829 0.116703477931135 no 487 0.0725315460143793 511 13842402 YBL026W LSM2
SGTC_1454 4239-0054 42.6 µM 1.45279188802283 0.117404055082776 no 488 0.0731407724610684 502 1340767
SGTC_2600 tangeritin 87.95 µM 1.45049900912162 0.117770211296895 no 489 0.0734597076536999 424 68077 A bioactive flavone.
SGTC_3274 9138298 49.47 µM 1.44859937640745 0.118074180467638 no 490 0.0737247477282802 477 17015756
SGTC_888 0916-0002 6.97 µM 1.44739036042385 0.118267929538966 no 491 0.0738938120146228 448 2802138 YIL048W NEO1
SGTC_1434 4073-0095 163 µM 1.4449195748177 0.11866458047463 no 492 0.0742402386575293 466 24133745
SGTC_849 0386-0493 241 µM 1.44060222495718 0.119359926354116 no 493 0.0748485457461617 431 726119
SGTC_1364 1653-0028 37.6 µM 1.43737135807219 0.119882162439665 no 494 0.0753062513564044 469 5718652
SGTC_1826 st055655 41.6 µM 1.43684196150452 0.11996788726503 no 495 0.075381452129376 470 676168
SGTC_837 0091-0265 12.5 µM 1.43660978475597 0.120005497115141 no 496 0.0754144508826348 486 759367
SGTC_1179 1021-1431 9.29 µM 1.43372555760487 0.12047340029663 no 497 0.0758252979185056 538 2840958
SGTC_3054 9094397 49.47 µM 1.43252855819573 0.12066796420489 no 498 0.0759963055458069 493 2598354
SGTC_150 3970-0969 77.2 µM 1.43114342277653 0.120893384279633 no 499 0.0761945572761099 553 6615640
SGTC_459 nigericin 15.3 µM 1.42610676001542 0.121715559490299 no 500 0.0769187638917473 494 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2636 apigenin dimethyl ether 100 µM 1.42491368001398 0.121910889828596 no 501 0.0770910773609103 508 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.42216301431999 0.122362065890328 no 502 0.0774894665180699 739 16725076
SGTC_1384 3089-0840 101 µM 1.42062752177408 0.122614433090171 no 503 0.0777125365570705 420 1069836
SGTC_845 0330-0138 4.51 µM 1.41976997052962 0.122755535469519 no 504 0.0778373300352296 463 9039800
SGTC_1644 st010134 20.9 µM 1.41811352092958 0.123028411781566 no 505 0.0780788121809195 446 3818134
SGTC_356 1634-0012 32.5 µM 1.41794379731837 0.123056395310182 no 506 0.0781035870581932 506 735457
SGTC_1210 3013-0140 750 nM 1.41661277203336 0.123276005537515 no 507 0.0782980861489672 486 905973
SGTC_428 3448-4153 16.5 µM 1.41256559750783 0.123945448628894 no 508 0.0788917451830054 422 3834874
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.40970435237622 0.124420259692565 no 509 0.0793134995247487 495 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2784 7567673 72.73 µM 1.406137461127 0.125013948756807 no 510 0.0798416551814043 510 3471247
SGTC_70 0141-0289 43.283 µM 1.40525008200913 0.125161954914138 no 511 0.0799734631811013 705 352408
SGTC_647 0140-0236 81 µM 1.39978764983162 0.126075730103085 no 512 0.0807884586126585 541 990837
SGTC_762 1165-0429 115 µM 1.39666263250475 0.126600580697832 no 513 0.0812575230675424 480 5967793
SGTC_419 nsc-638432 893 µM 1.39594657387472 0.126721057641281 no 514 0.0813652920908445 480 368090
SGTC_2124 5246320 200 µM 1.38911914262173 0.127873783882464 no 515 0.0823982618504549 471 579342
SGTC_3231 9132313 49.47 µM 1.38851199254439 0.127976645238506 no 516 0.0824905977625131 489 4905967
SGTC_429 1112-0049 25.5 µM 1.38766756913158 0.128119800208274 no 517 0.0826191478889453 460 2836170
SGTC_2999 9069765 71.4286 µM 1.38701489118342 0.128230524780478 no 518 0.0827186110622649 510 2097066
SGTC_486 niguldipine 82 µM 1.38637315911285 0.128339457194117 no 519 0.0828164939953221 419 1236 A calcium channel blocker.
SGTC_1186 1319-0216 26 µM 1.38622275370958 0.128364997426198 no 520 0.0828394478249876 525 4565136
SGTC_3132 9126706 49.47 µM 1.38192457487334 0.129096359675045 no 521 0.0834974306986105 448 850858
SGTC_3279 9140807 49.47 µM 1.37920164253591 0.129561175920322 no 522 0.0839162958953261 475 45595718
SGTC_1792 st045773 43.6 µM 1.37674690333033 0.129981203048114 no 523 0.0842952560052589 485 2919270
SGTC_1171 0368-0077 21.4 µM 1.37509036061796 0.130265183964589 no 524 0.0845517162173768 455 3239779
SGTC_875 0709-0210 25.7 µM 1.37253076845746 0.130704818066262 no 525 0.084949133646835 545 6251364
SGTC_604 1000-0114 314 µM 1.37193934668939 0.130806546046205 no 526 0.0850411601273648 535 1572745
SGTC_2742 clothiapine 36.27 µM 1.37026114994687 0.131095503537629 no 527 0.0853026979088578 433 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.36918114723101 0.131281695027776 no 528 0.0854713288137367 487 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2071 5230951 39.92 µM 1.36645300123511 0.131752837938672 no 529 0.0858984114395956 525 1799272
SGTC_2902 5787006 60.46 µM 1.36642146016557 0.131758291803252 no 530 0.0859033584162128 477 591003
SGTC_1251 0490-5699 265 µM 1.36418240177427 0.132145852429444 no 531 0.0862550827272237 568 3883818
SGTC_998 3996-0085 177 µM 1.36129321728226 0.13264710441473 no 532 0.0867105228046827 553 715391
SGTC_1167 k781-0610 148 µM 1.35897328499974 0.133050542300231 no 533 0.0870775271553411 543 4525169
SGTC_1624 st003710 6.25 µM 1.35820485490147 0.133184358863276 no 534 0.0871993452564108 569 24207033
SGTC_1996 st072960 66.8 µM 1.35657275437427 0.133468884588332 no 535 0.0874585018553268 527 1719405
SGTC_2730 imipramine 71.33 µM 1.35481344054359 0.133776055452594 no 536 0.0877385016390322 606 3696 A tricyclic antidepressant.
SGTC_1824 st053723 68.6 µM 1.35450110659707 0.133830638767224 no 537 0.0877882802932795 507 675225
SGTC_484 loperamide 105 µM 1.35366766388516 0.133976365690005 no 538 0.0879212144837952 389 3955 An opioid-receptor agonist.
SGTC_2447 5741742 33.78 µM 1.34872441098674 0.134842931288906 no 539 0.0887127508440391 526 1776504
SGTC_1329 1447-1697 50.6 µM 1.34843162838513 0.134894377219436 no 540 0.088759798473987 538 2840515
SGTC_1877 wortmannin 25 µM 1.3474958848568 0.135058890506617 no 541 0.0889102889474234 570 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2308 7584454 197.62 µM 1.34520095782213 0.135462944507196 no 542 0.0892801735004575 582 893577
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.34165538945537 0.136088818482534 no 543 0.0898538788950495 544 165521
SGTC_2396 5342950 42.78 µM 1.34129464282991 0.136152609278922 no 544 0.0899124042281561 569 1886677
SGTC_2135 5326629 150.42 µM 1.33965428729514 0.136442931286318 no 545 0.0901788828300259 492 5020077
SGTC_3105 9121040 49.47 µM 1.33642988769157 0.13701484243849 no 546 0.0907044014053958 279 41448907
SGTC_3141 9094609 49.47 µM 1.33535607397806 0.137205667645064 no 547 0.0908799170681327 501 25236309 YDL196W YDL196W
SGTC_986 1493-0483 84 µM 1.33394210134662 0.137457218575219 no 548 0.0911114161550075 495 40079
SGTC_1285 0929-0069 65.5 µM 1.32579636776487 0.138912504884582 no 549 0.0924535782325388 525 1206237
SGTC_2807 7945238 51.95 µM 1.31740565615411 0.140422490155608 no 550 0.0938513430097841 552 17148797
SGTC_2949 9072542 2.23 µM 1.3155495376805 0.140758015339147 no 551 0.0941626400857758 561 16457352
SGTC_231 b-estradiol 524 µM 1.31345732888976 0.141136869585141 no 552 0.0945144452761916 465 450 A steroid.
SGTC_1049 3226-0134 66 µM 1.31310300886452 0.141201097759169 no 553 0.0945741200630458 567 5702385
SGTC_2868 9035608 32.47 µM 1.31305349654253 0.141210074517077 no 554 0.0945824611687481 555 6462614
SGTC_2923 7992654 58.14 µM 1.31114429952616 0.141556513766607 no 555 0.0949045082788935 525 2985126
SGTC_1991 st073000 8.92 µM 1.31075320666826 0.141627551735134 no 556 0.0949705781724376 601 4301969 YIL048W NEO1
SGTC_1236 0330-0013 258 µM 1.30882252804951 0.141978593369852 no 557 0.0952972369999241 521 4617066
SGTC_1257 0669-0121 16 µM 1.30855209849567 0.142027810655232 no 558 0.095343057970627 605 4307855
SGTC_2533 agelasine 13.65 µM 1.30526489385651 0.142626994486273 no 559 0.095901331872617 579 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1493 4348-0038 111 µM 1.30513643364572 0.142650444559313 no 560 0.0959231972904356 591 800424
SGTC_143 4032-1194 15.74 µM 1.30458668873775 0.142750828492651 no 561 0.096016811669639 644 1806963
SGTC_340 k038-0059 454 µM 1.30214993950765 0.143196356040264 no 562 0.0964325671524759 551 23733424
SGTC_1068 loratadine 26.9 µM 1.29909458547826 0.143756313157384 no 563 0.0969557355264875 521 3957 A H1 histamine antagonist.
SGTC_2290 7904846 200 µM 1.2985377909399 0.143858516267174 no 564 0.0970512995121713 550 2962154
SGTC_1764 st044502 93.5 µM 1.2960468449091 0.144316345017745 no 565 0.097479673155701 553 8407
SGTC_25 0118-0223 35.662 µM 1.29432616414962 0.14463317411626 no 566 0.0977763913333528 530 5333628
SGTC_2106 5357045 167.29 µM 1.29266895170455 0.14493875941131 no 567 0.0980627902915534 563 668842
SGTC_3167 9103034 49.47 µM 1.28569701288253 0.146229123721805 no 568 0.0992744120754254 469 5127859
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.28446670659667 0.146457626828954 no 569 0.0994893527902333 550 6312947
SGTC_1030 k029-0042 36.7 µM 1.28352538121202 0.146632619682058 no 570 0.0996540366173254 608 6080581
SGTC_1473 k844-0725 134 µM 1.28173975617522 0.146964953644122 no 571 0.0999669768407923 639 54682906
SGTC_1419 3993-2473 62.6 µM 1.279891837933 0.147309412878864 no 572 0.100291589292641 569 704026
SGTC_967 1306-0166 352 µM 1.27599581828893 0.148037418003854 no 573 0.100978498661312 563 4437607
SGTC_3322 9139058 2.11 µM 1.27492628914818 0.148237689348965 no 574 0.101167666531353 560 4908926 YPR165W RHO1
SGTC_2957 9076800 11.52 µM 1.26888445917786 0.149372436455954 no 575 0.102241137943248 505 16459615
SGTC_3349 9149703 23.001 µM 1.26712178770625 0.149704582645293 no 576 0.102555873065632 540 4910494
SGTC_2539 epi(13)torulosol 80 µM 1.26645619966498 0.149830129726545 no 577 0.102674900644708 550 6708597
SGTC_2126 5251174 33.877 µM 1.26500791948628 0.15010355533499 no 578 0.10293424448343 667 790722
SGTC_414 piperonyl butoxide 100 µM 1.26430100115031 0.150237137520133 no 579 0.103061005198847 557 5794 A potent inhibitor of cytochrome P450.
SGTC_985 1493-0307 8.71 µM 1.26150263188855 0.150766706228972 no 580 0.103563906173786 511 3278274
SGTC_1691 st019933 84.6 µM 1.26139922973762 0.150786298029229 no 581 0.103582522854764 547 6176082
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.26126475736948 0.150811779297423 no 582 0.103606737097547 423 88881 An O-methylated flavonoid and antioxidant.
SGTC_926 2268-1401 59.4 µM 1.25886269542301 0.151267430741074 no 583 0.104039965077769 574 2931578
SGTC_1332 1480-0653 17.5 µM 1.25446915788129 0.152103215628138 no 584 0.104835764607282 574 5749438
SGTC_197 4544-0043 41.561 µM 1.2540431689437 0.152184414494192 no 585 0.104913157549238 617 896523
SGTC_1645 Cervolide 78 µM 1.25305780772758 0.152372347041566 no 586 0.105092334768413 525 23173 A fragrance.
SGTC_139 0099-0334 718.624 µM 1.25305641248227 0.152372613258228 no 587 0.105092588635521 661 97690
SGTC_1850 st056238 17 µM 1.25048811738443 0.152863174388886 no 588 0.105560646669605 643 5393177
SGTC_3230 9131665 49.47 µM 1.24820674098542 0.153299809549647 no 589 0.105977677983644 444 15943720
SGTC_2971 9092186 9.93 µM 1.24481640011689 0.153950215679504 no 590 0.106599623149319 531 25236400
SGTC_1352 1496-0991 99 µM 1.23929976499675 0.155012429488611 no 591 0.107617252859485 593 3000039
SGTC_1141 3253-0389 52.6 µM 1.23887941218275 0.155093565301264 no 592 0.107695079543801 566 5402031
SGTC_1672 st016598 6.51 µM 1.23497572161026 0.155848388369226 no 593 0.108419769984796 604 4665860 YNL267W PIK1
SGTC_1771 st048882 4.1505 µM 1.23443090965953 0.155953926244733 no 594 0.108521188535988 596 4580403
SGTC_1520 flindersine 88 µM 1.23439548478796 0.155960790180326 no 595 0.108527785355603 611 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_488 nitrendipine 139 µM 1.22793535669066 0.157215836141973 no 596 0.109735617774659 623 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3251 9135047 49.47 µM 1.22591344042354 0.157610006084576 no 597 0.110115625202998 530 17682963
SGTC_2195 6536160 144.242 µM 1.2258358538414 0.157625144412494 no 598 0.11013022593469 533 3834386
SGTC_638 3970-0837 4.09 µM 1.22548503762493 0.157693605942696 no 599 0.110196262076268 609 4118451 YLR208W SEC13
SGTC_655 k060-0012 42 µM 1.22386956437828 0.15800911641663 no 600 0.110500718357139 600 5994525
SGTC_3077 9117319 49.47 µM 1.22346106262306 0.158088964574478 no 601 0.110577801088748 532 17154678
SGTC_944 3370-0224 231 µM 1.22092622505077 0.158585030845719 no 602 0.111056977005046 600 4580514
SGTC_1097 itavastatin 7.23 µM 1.21697006692059 0.159361286324028 no 603 0.111807802421403 617 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3074 9116018 49.47 µM 1.21166156884026 0.160406792819232 no 604 0.112820977983252 558 17027303
SGTC_1091 telmisartan 47.6 µM 1.2109920643909 0.160538969001752 no 605 0.112949223042394 614 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_674 0498-0004 451 µM 1.20941761218678 0.160850083818694 no 606 0.113251222832791 592 4231473
SGTC_734 2023-0417 80 µM 1.20884728499385 0.160962878632852 no 607 0.1133607607815 608 3935732
SGTC_937 3122-0005 46.7 µM 1.20731133648391 0.161266903088943 no 608 0.113656133228557 653 759535
SGTC_753 1322-0200 289 µM 1.20641443061604 0.161444609059485 no 609 0.11382886732335 618 5403907
SGTC_1853 st056710 91.2 µM 1.20553746370282 0.16161848789841 no 610 0.113997942213411 628 269167
SGTC_1730 st033808 45.1 µM 1.20532748054794 0.16166013999089 no 611 0.114038452464599 692 1045166
SGTC_2725 haloperidol 53.21 µM 1.20236914796876 0.162247696087103 no 612 0.114610268497873 620 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1281 0884-0031 11.8 µM 1.200162811624 0.16268680175514 no 613 0.115038057563124 641 1548255
SGTC_271 rotenone 740 µM 1.19936611242958 0.162845550837868 no 614 0.115192809167877 654 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1312 1218-2183 165 µM 1.19870957585148 0.162976447011412 no 615 0.11532044664145 649 6744073
SGTC_3128 9127691 49.47 µM 1.19794057588246 0.163129852391018 no 616 0.115470075943105 517 41316314
SGTC_3283 9109332 35.8195 µM 1.19693384929124 0.163330822903207 no 617 0.115666169699479 519 17027281
SGTC_676 falcarinol 140 µM 1.18963925180818 0.164791829342245 no 618 0.117094105655512 646 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3096 9117468 49.47 µM 1.18864136605886 0.164992348212145 no 619 0.117290411316032 508 41316311
SGTC_3228 9131799 49.47 µM 1.18812051498751 0.165097072685972 no 620 0.117392966495592 611 17015818
SGTC_3154 9100113 49.47 µM 1.18666714196374 0.165389521393695 no 621 0.117679470298045 623 25237525
SGTC_1717 st033143 58.0435 µM 1.1850026309739 0.165724866903331 no 622 0.118008203335212 685 674616
SGTC_2704 st078022 71.1 µM 1.1787741124188 0.166983610655535 no 623 0.119244067629966 643 54697681
SGTC_291 SEC14.278 35.5 µM 1.17875668766759 0.166987140712889 no 624 0.119247537819493 662 1068044
SGTC_2242 6630449 61.2675 µM 1.17777627459635 0.167185838836599 no 625 0.119442904756035 557 691249 YDR170C SEC7
SGTC_3257 9139206 32.98 µM 1.17763830249512 0.167213813562722 no 626 0.119470416576243 579 4910041
SGTC_400 oxethazaine 37.5 µM 1.17523275405635 0.167702038771818 no 627 0.119950804754077 613 4621 A local anesthetic.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.17511797291774 0.167725357441558 no 628 0.11997376054132 620 140250 A respiratory chain inhibitor.
SGTC_1840 st055363 71 µM 1.17143719084628 0.168474243512552 no 629 0.120711545254368 583 676033
SGTC_2109 5483026 200 µM 1.16960114758415 0.168848604416185 no 630 0.121080757655101 658 759335
SGTC_480 am 92016 50 µM 1.16747085405597 0.169283630893616 no 631 0.12151013597684 592 2129 K+ channel blocker.
SGTC_3143 9086658 49.47 µM 1.16696205779149 0.169387638344586 no 632 0.121612846236718 723 25236626
SGTC_2456 5770359 74.46 µM 1.1658645916069 0.169612120517395 no 633 0.121834598493002 665 3118787
SGTC_1861 st057647 17.4 µM 1.1646988961284 0.169850767623212 no 634 0.122070447990917 672 688668
SGTC_3323 9138564 53.9225 µM 1.1624986845896 0.170301792502394 no 635 0.122516479346903 717 43912313 YNL103W MET4
SGTC_1045 1348-1485 165 µM 1.16111577087632 0.170585670496537 no 636 0.122797411001088 699 6810614
SGTC_337 1315-0038 354 µM 1.16001635005916 0.170811570448437 no 637 0.123021074678664 657 1626437
SGTC_2799 7812892 81.82 µM 1.15533511975747 0.171775572887519 no 638 0.123976609745679 696 20205235
SGTC_3324 9138759 60.749 µM 1.15465668786586 0.171915569619541 no 639 0.124115521350973 644 45595710
SGTC_2342 7990637 118.86 µM 1.14947335008182 0.172987572558822 no 640 0.125180424800983 688 2033102 YER133W GLC7
SGTC_3079 9117512 49.47 µM 1.14652583589264 0.173599064251659 no 641 0.125788821719511 698 7185044
SGTC_2324 6149169 200 µM 1.14637375504348 0.173630652234941 no 642 0.125820268612372 633 2888231
SGTC_492 tmb-8 126 µM 1.14082255389739 0.174786168011211 no 643 0.126971886508236 494 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2474 5321570 43.32 µM 1.1393695969076 0.175089413887464 no 644 0.127274515626839 650 2841384
SGTC_979 1426-2828 121 µM 1.13750851263757 0.175478327011961 no 645 0.127662884000764 713 747872
SGTC_1163 k060-0048 49.9 µM 1.13708412118922 0.175567089237643 no 646 0.127751560620753 720 6809982
SGTC_1667 st014849 34.6 µM 1.13195606369863 0.176641879892011 no 647 0.128826453266315 710 5348460
SGTC_318 1488-0629 67.2 µM 1.13146634934803 0.17674473640866 no 648 0.128929429539605 638 3662576
SGTC_2790 5423970 71.43 µM 1.12924661800882 0.177211429430875 no 649 0.129396906508389 724 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1750 st081859 2.357 µM 1.12863153572838 0.177340886546321 no 650 0.129526650835535 838 5291695
SGTC_1093 fluphenazine 7.97 µM 1.12840764815033 0.177388023256933 no 651 0.129573899636386 705 6602611 An atypical antipsychotic.
SGTC_2703 st077852 53.4 µM 1.12697143807827 0.177690587299414 no 652 0.129877278580869 646 6281836
SGTC_60 0986-0278 202 µM 1.12317115776725 0.178492755746858 no 653 0.130682404771016 546 3110598
SGTC_2695 st077686 51.995 µM 1.12109478197869 0.178932002137208 no 654 0.131123759777912 648 2876092
SGTC_2638 epoxomicin 18 µM 1.12052190977598 0.179053309872671 no 655 0.131245710671988 731 9915668 A protesome inhibitor.
SGTC_179 1273-0063 6.77 µM 1.12035177175181 0.179089347170363 no 656 0.131281944100219 624 3108139
SGTC_2201 6605497 169.863 µM 1.11827990860407 0.179528558976821 no 657 0.131723732524686 676 670741
SGTC_630 4356-0227 183 µM 1.11809884474335 0.179566974631994 no 658 0.131762389897556 663 779312
SGTC_2960 9079389 5.97 µM 1.11605722730606 0.180000494606042 no 659 0.132198819670089 714 16457355
SGTC_3216 9129716 49.47 µM 1.11529159831671 0.180163238661193 no 660 0.132362742288803 636 8056934
SGTC_196 k015-0023 18.111 µM 1.11393414591588 0.180452009177505 no 661 0.132653719672649 715 5211998
SGTC_3237 9133362 49.47 µM 1.11014928448461 0.181258694139169 no 662 0.133467351347012 687 43845137
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.10822656762812 0.181669355328311 no 663 0.133881989852224 642 364106
SGTC_2962 9082311 13.18 µM 1.10772970813655 0.181775571056186 no 664 0.13398928258992 650 16459453
SGTC_3097 9117246 49.47 µM 1.10649202010299 0.182040325669717 no 665 0.134256808033416 694 16423892
SGTC_2532 xanthone 78.9 µM 1.10617735261726 0.182107674807122 no 666 0.134324881650857 636 7020 An insecticide.
SGTC_1459 k035-0031 35.7 µM 1.10576850547668 0.182195204736178 no 667 0.134413365032403 619 3877128 YMR208W ERG12
SGTC_377 3970-0964 33.1 µM 1.10471039268334 0.182421857766139 no 668 0.134642549353157 785 16481235
SGTC_1524 corynanthine 62.1 µM 1.10245545298441 0.182905464452974 no 669 0.135131857471401 672 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2866 9034245 58.44 µM 1.10234865130074 0.182928389553645 no 670 0.135155062987556 680 6462273
SGTC_1938 st074717 56.4 µM 1.10024694757722 0.183379887388915 no 671 0.135612270185873 638 17250979
SGTC_9 0092-0002 10.449 µM 1.10023139171195 0.183383231760833 no 672 0.13561565817344 725 759368
SGTC_3024 9090631 49.47 µM 1.10013941291992 0.183403007155694 no 673 0.135635691867042 667 25236383
SGTC_1900 st060200 72.8 µM 1.09784134413035 0.183897522300803 no 674 0.136136887233945 710 688945
SGTC_1464 k208-0027 110 µM 1.09267830794235 0.185011566943496 no 675 0.137267533583772 729 X1464
SGTC_1997 st073024 93.8 µM 1.09204928520691 0.185147579132508 no 676 0.13740571943669 707 686268
SGTC_572 0960-0087 17.7 µM 1.09116443738588 0.185339012910872 no 677 0.137600266553555 756 6796365
SGTC_8 0354-0001 70 µM 1.09057303213639 0.185467029890657 no 678 0.1377304006793 810 4993152
SGTC_2988 9073640 71.4286 µM 1.09053264588034 0.185475773996711 no 679 0.137739290423275 667 9102229
SGTC_960 1222-0186 7.7 µM 1.08956899122599 0.18568449261039 no 680 0.13795152434455 742 3126296
SGTC_971 1315-0384 26.7 µM 1.08495483360516 0.186685894099309 no 681 0.138970830051301 697 6769120
SGTC_2173 5763948 167 µM 1.08311426879692 0.187086279314012 no 682 0.139378853155979 739 2867177
SGTC_1059 3448-6867 171 µM 1.08217590429676 0.187290609660304 no 683 0.13958718656989 737 3934407
SGTC_1781 st038725 66.3 µM 1.07983154954765 0.187801699252895 no 684 0.140108599583056 787 4270275 YIL048W NEO1
SGTC_2653 dihydrofissinolide 100 µM 1.07977161345414 0.187814777121407 no 685 0.140121947423743 718 6857746
SGTC_375 3970-0961 9.27 µM 1.07965650199133 0.187839895660601 no 686 0.140147585308848 724 2898222
SGTC_2199 6590217 200 µM 1.07910952170086 0.187959280895313 no 687 0.140269453540847 652 703109
SGTC_2492 derrusnin 100 µM 1.07709769302921 0.188398790347127 no 688 0.140718311807929 658 1715307 Part of coumarin class of compounds.
SGTC_1144 3486-0183 12.5 µM 1.07558027423963 0.188730708705326 no 689 0.141057506645281 762 6744069
SGTC_752 1896-0090 130 µM 1.07391733010541 0.189094872754974 no 690 0.141429867668448 734 772567
SGTC_2808 7946468 45.46 µM 1.07354966866528 0.189175444408512 no 691 0.141512283056599 761 2970879
SGTC_2461 5755302 26.15 µM 1.07250528476058 0.18940443259412 no 692 0.141746570772789 765 2788904
SGTC_2671 danthron 100 µM 1.07242713184422 0.18942157500377 no 693 0.141764113456079 722 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1762 st045503 25.4615 µM 1.06961947394488 0.190038052415458 no 694 0.142395312960531 733 4645554
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.06784427747833 0.190428467852393 no 695 0.142795380729648 716 803109
SGTC_1398 3558-0053 112 µM 1.06693032697963 0.190629663105008 no 696 0.143001649505638 669 4532369
SGTC_2939 9044578 71.43 µM 1.0651496526415 0.191022031816278 no 697 0.143404106509348 702 2653634
SGTC_251 melphalan 456.522 µM 1.06275450869604 0.191550578434281 no 698 0.143946647202974 838 460612 A DNA alkylator.
SGTC_430 0958-0115 16.4 µM 1.06195710608269 0.191726743261125 no 699 0.144127579199658 715 6833180
SGTC_389 tpck 16.7 µM 1.06086748614553 0.191967626056817 no 700 0.144375063630615 734 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1976 st070609 63.5 µM 1.05949971666398 0.192270261561844 no 701 0.144686129104958 768 682556
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.05824421445352 0.192548313292123 no 702 0.144972059238955 791 6708784 An antioxidant flavonoid
SGTC_1968 st069590 43.6 µM 1.0581753583059 0.192563569731259 no 703 0.14498775164654 724 6384066
SGTC_1923 st058458 19.1 µM 1.0578579519549 0.192633906928895 no 704 0.145060103759937 799 3534982
SGTC_2009 4012297 12.05 µM 1.05772788535876 0.192662734201044 no 705 0.145089759186659 704 45595307
SGTC_3296 9122258 64.045 µM 1.0573674638137 0.19274262989859 no 706 0.145171957290186 736 4730474
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.05310512574739 0.193689009424735 no 707 0.14614640695411 720 641818 YHR062C RPP1
SGTC_2791 5663188 71.43 µM 1.05236452691669 0.193853735222123 no 708 0.146316168579865 718 54690634
SGTC_940 3232-1287 54.8 µM 1.05152345008667 0.194040913098619 no 709 0.146509122499845 771 1585493 YIL048W NEO1
SGTC_1040 k898-0338 155 µM 1.05058392465947 0.194250130420405 no 710 0.146724863675183 822 20969351
SGTC_1133 3473-0247 50 µM 1.04720197694254 0.195004372775293 no 711 0.147503216850124 734 711311
SGTC_2313 7726885 200 µM 1.0454690191273 0.195391546197927 no 712 0.14790312601712 728 726423
SGTC_45 0kpi-0036 14.9 µM 1.0429591354405 0.19595312581386 no 713 0.148483609682611 706 2795021
SGTC_1952 st077036 64.1 µM 1.04152861181579 0.196273639226595 no 714 0.148815140628195 754 2937007
SGTC_2682 pyrogallin 40.03 µM 1.03753643409536 0.19716977918116 no 715 0.149742962478574 816 822798 An ATP competetive kinase inhibitor.
SGTC_2483 5729050 27.16 µM 1.03747138486755 0.197184401507194 no 716 0.149758112449606 859 2865180
SGTC_1060 3448-7350 82 µM 1.03687692699733 0.197318059263233 no 717 0.149896609108353 770 570178
SGTC_1416 3966-0321 25.3 µM 1.03516384938789 0.19770353358019 no 718 0.150296199162457 786 582530 YLR208W SEC13
SGTC_1820 st053765 18.6 µM 1.03515369617817 0.197705819596987 no 719 0.150298569599888 724 3690829
SGTC_883 0850-0245 24.6 µM 1.0320332370603 0.198409154297688 no 720 0.151028273759017 805 6823229 YPR165W RHO1
SGTC_2696 st077691 74.316 µM 1.03168214831516 0.198488382190558 no 721 0.151110521452364 689 757133
SGTC_3165 9101544 49.47 µM 1.0307359064533 0.198702009400588 no 722 0.15133234087612 775 5002184
SGTC_1331 1472-0049 76.2 µM 1.0278260619658 0.199359815289307 no 723 0.152015827259148 727 24051409
SGTC_606 k015-0008 38.6 µM 1.02616098718944 0.19973681488444 no 724 0.152407853561543 856 1970475
SGTC_3125 9127534 49.47 µM 1.02379418379156 0.200273434583606 no 725 0.152966249065445 661 1639235
SGTC_957 1187-1561 14.1 µM 1.02337682691883 0.200368150680789 no 726 0.153064855792942 775 1538454
SGTC_814 3342-0569 96 µM 1.02215087462255 0.200646527186399 no 727 0.153354748746203 800 4346283
SGTC_1872 amphotericin b 148 nM 1.01973543838143 0.201195678307391 no 728 0.153926974850552 820 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_742 0kpi-0133 140 µM 1.0191917793508 0.201319403704217 no 729 0.154055964312512 821 2728852
SGTC_2285 7945142 200 µM 1.01828804015562 0.201525176694332 no 730 0.154270545204065 735 2970608
SGTC_2142 5622915 118.518 µM 1.01527285414812 0.202212617489426 no 731 0.15498789030853 753 5322196
SGTC_3224 9130643 49.47 µM 1.01276500498764 0.202785456369513 no 732 0.155586209894578 747 17644395
SGTC_3355 9151058 44.0485 µM 1.01140095846133 0.203097436358411 no 733 0.15591228131413 770 17015728
SGTC_3042 9091578 49.47 µM 1.01082787274549 0.203228595977813 no 734 0.1560494101077 771 25236497
SGTC_1843 st055809 45.5 µM 1.01012076115181 0.203390499167196 no 735 0.156218718318959 742 16413835
SGTC_2588 indole-3-carbinol 100 µM 1.00728070508945 0.204041544959077 no 736 0.156899949662107 840 3712 Induces cell cycle arrest.
SGTC_2536 dehydroabietamide 32.04 µM 1.00649219824354 0.204222519825661 no 737 0.157089431351213 835 3983547
SGTC_2019 4016004 108 µM 1.00160490490337 0.205346362091812 no 738 0.158267225553457 719 45595336
SGTC_1606 st000094 49.2 µM 0.998455346992567 0.206072551319347 no 739 0.159029303404059 860 1242210
SGTC_1125 tnp00248 1.32998 µM 0.998131226382397 0.206147369685813 no 740 0.1591078649564 928 24207736
SGTC_1394 3474-0001 65.7 µM 0.998011789860245 0.206174943870295 no 741 0.159136820831819 700 5017666 YIL048W NEO1
SGTC_2476 5806916 10.51 µM 0.996972641065423 0.206414943319585 no 742 0.159388894983544 783 2870194
SGTC_2881 9058953 51.95 µM 0.995643827233055 0.206722084206178 no 743 0.159711616052151 865 17122249
SGTC_1959 st077091 55.8 µM 0.993797058615092 0.20714939378978 no 744 0.160160839213716 820 821356 YKL052C ASK1
SGTC_1857 st056007 79.3 µM 0.992819274967258 0.207375847011869 no 745 0.160399017462003 788 619834
SGTC_1772 st048439 82.2 µM 0.991988872715008 0.207568281803159 no 746 0.160601476739618 796 2927068 YDL195W SEC31
SGTC_117 lucigenin 22.078 µM 0.98876103896312 0.208317291429785 no 747 0.161390035328661 836 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2043 5101342 149 µM 0.98409041252585 0.209403915078616 no 748 0.162535530250209 782 678451
SGTC_1610 st001799 48.1 µM 0.984044781643107 0.209414547551832 no 749 0.162546747488065 745 621897
SGTC_2452 5863136 48.41 µM 0.982351225907184 0.209809388392418 no 750 0.162963423049519 802 2184096
SGTC_234 nsc-17383 10.7 µM 0.98131832723961 0.210050416297223 no 751 0.163217893843245 876 408974
SGTC_2973 9094665 17.96 µM 0.980973079427019 0.210131016470976 no 752 0.163303008604438 878 25237061 YIL048W NEO1
SGTC_3284 9108171 64.8615 µM 0.980304281716509 0.210287202984526 no 753 0.163467970909503 771 8687505
SGTC_892 0929-0076 29 µM 0.97991775274345 0.210377501433667 no 754 0.163563359549271 835 5751038
SGTC_2648 atorvastatin 78.68 µM 0.977193697083674 0.211014523286126 no 755 0.164236633900335 806 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_406 estrone 100 µM 0.976887390566293 0.211086223880085 no 756 0.16431245250039 853 5870 A steroid.
SGTC_763 3453-1109 128 µM 0.975135629293567 0.211496552506471 no 757 0.164746493600066 868 1560353
SGTC_2809 7964133 12.99 µM 0.973778740381296 0.211814707871698 no 758 0.165083205562545 816 1253665
SGTC_3067 9117431 49.47 µM 0.97281829802884 0.212040075930896 no 759 0.165321808405124 783 17150885
SGTC_2580 diallyl disulphide 81.36 µM 0.972333613505648 0.212153860504153 no 760 0.16544230333581 786 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2820 7989630 71.43 µM 0.96800332579651 0.213172022215552 no 761 0.166521354363123 718 2984098
SGTC_1219 1469-0211 33.1 µM 0.967671807835752 0.213250087857522 no 762 0.166604151102164 826 6822282
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.960070296903456 0.215044655497573 no 763 0.168509918245786 873 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3057 9095946 49.47 µM 0.956550358680869 0.21587860534245 no 764 0.169397127441194 873 24540043
SGTC_2526 patulin 37.61 µM 0.955976268573518 0.216014797298147 no 765 0.169542112119295 883 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1340 1486-1359 257 µM 0.955849704838651 0.216044828830969 no 766 0.169574086106165 846 4309068
SGTC_1213 1315-0166 115 µM 0.955523280898407 0.216122295128353 no 767 0.16965656893174 727 768401
SGTC_2370 9071495 200 µM 0.950670169669831 0.217275922192237 no 768 0.170885917835547 798 21791103
SGTC_372 0155-0182 15.9 µM 0.949495506869304 0.217555683479546 no 769 0.171184328070902 914 771486
SGTC_1339 1486-1321 22.7 µM 0.948697250427696 0.217745917263603 no 770 0.171387306435982 851 3469382
SGTC_3234 9132280 49.47 µM 0.948019585280084 0.217907488026254 no 771 0.171559741875693 838 17612295
SGTC_2507 purpurin 79.67 µM 0.947354147391544 0.218066210786978 no 772 0.171729173859289 854 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_510 ag-490 170 µM 0.946747168057018 0.218211047894474 no 773 0.1718838144626 934 5328779
SGTC_3111 9122088 49.47 µM 0.946705198246632 0.218221064758398 no 774 0.171894510430015 740 16876704
SGTC_2401 5128683 200 µM 0.945725615105212 0.218454935467691 no 775 0.172144277004584 781 708373
SGTC_3172 9105863 49.47 µM 0.945525149461042 0.218502813451054 no 776 0.172195418727839 815 2348785
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.943552067711167 0.218974374483773 no 777 0.172699298048975 810 6708514
SGTC_3031 9088762 49.47 µM 0.942237992581847 0.219288759249733 no 778 0.173035403284983 907 205253
SGTC_2369 9071472 200 µM 0.940241397416788 0.219766929099658 no 779 0.17354687585502 885 17296037
SGTC_2617 dihydrotanshinone i 20.83 µM 0.939638936478813 0.219911331532065 no 780 0.173701398481658 892 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_87 0100-0052 35.5 µM 0.939254516795096 0.220003500623197 no 781 0.173800042369457 1045 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3050 9093513 49.47 µM 0.937319875294276 0.220467689737092 no 782 0.174297021152144 880 25236664
SGTC_3086 9117350 49.47 µM 0.936812476069884 0.22058952565142 no 783 0.174427513302608 827 2679265
SGTC_1657 st012939 43.4 µM 0.936442102358596 0.220678483562229 no 784 0.174522804615684 830 24207257
SGTC_723 4182-0001 115 µM 0.935169250433171 0.220984359084073 no 785 0.174850541334272 823 744821 YLR208W SEC13
SGTC_938 3126-1755 342 µM 0.934612113824016 0.221118319356256 no 786 0.174994116921971 914 1777771
SGTC_3085 9117376 49.47 µM 0.933894991626939 0.2212908156121 no 787 0.175179031294741 879 16480349
SGTC_2450 5739737 12.93 µM 0.933862336811695 0.221298672218568 no 788 0.175187454488921 813 2262825
SGTC_764 1951-2361 146 µM 0.93258126611367 0.221607018123069 no 789 0.175518104842245 833 5438930
SGTC_2257 7960413 200 µM 0.931770374846674 0.221802321535861 no 790 0.175727603965713 919 2974689 YIL048W NEO1
SGTC_1811 st050069 61.5 µM 0.92987982740512 0.222258042097621 no 791 0.176216654330767 883 3877702
SGTC_2406 ethylparaben 405.7 µM 0.92958518012266 0.222329115554413 no 792 0.17629295175584 727 8434 A possible steroid mimic.
SGTC_1359 1582-0056 520 nM 0.928453206015408 0.222602285679651 no 793 0.176586265112442 937 3661189
SGTC_1697 st025554 27.742 µM 0.924891060868506 0.223463156640494 no 794 0.177511288464239 852 1269519
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.924887533870038 0.223464009954997 no 795 0.177512205873665 877 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_166 k072-0058 166.424 µM 0.920951932213931 0.224417335436501 no 796 0.178537761687611 931 5846229
SGTC_454 lyso-paf C-16 6.67 µM 0.920644421963487 0.224491921108681 no 797 0.178618050898043 927 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1007 4101-0031 70 µM 0.919489342410434 0.224772207742406 no 798 0.178919838788793 916 1146276
SGTC_93 0109-0045 59.227 µM 0.918825478762374 0.224933387794946 no 799 0.179093431717876 1040 88733
SGTC_2491 paeonol 100 µM 0.917788163096499 0.225185369709933 no 800 0.17936489022949 868 11092 Increases levels of cortical cytochrome oxidase.
SGTC_525 k781-2675 26.7 µM 0.916838399101566 0.225416223972479 no 801 0.179613663808202 892 3651118 YDL195W SEC31
SGTC_2787 5284540 71.43 µM 0.915025534533049 0.225857239400048 no 802 0.180089112640778 887 736958
SGTC_2950 9072895 21.46 µM 0.91349785856996 0.226229255551517 no 803 0.180490379667259 912 17332245
SGTC_3151 9099821 49.47 µM 0.911699438775859 0.226667645958794 no 804 0.180963479752888 873 17174189
SGTC_2724 maprotiline 69.64 µM 0.91136544449266 0.226749114572227 no 805 0.181051427217802 915 4011 A tricyclic antidepressant.
SGTC_1447 4239-0816 81.9 µM 0.909744631918157 0.227144701259947 no 806 0.181478600225303 833 1341554
SGTC_2750 bromebric acid 70.15 µM 0.909409469845279 0.227226551739048 no 807 0.181567012469999 943 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3320 9137005 35.139 µM 0.908355767851847 0.22748398627668 no 808 0.181845143574589 847 4908713
SGTC_1683 st010134 710 nM 0.905695478506419 0.228134663532964 no 809 0.182548528188767 877 3818134
SGTC_2193 5925765 200 µM 0.904989674162731 0.228307470937211 no 810 0.182735428791301 895 877370
SGTC_3059 1327-0034 3 µM 0.904584428426733 0.228406723547411 no 811 0.182842793904646 879 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1550 gossypolone 36.6 µM 0.901630409577252 0.229130952642365 no 812 0.183626615736076 958 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1677 st019204 53.9 µM 0.900822364528052 0.229329283051762 no 813 0.18384138725755 841 3945625
SGTC_1413 3910-0535 34.4 µM 0.900432629107813 0.229424975953755 no 814 0.183945031534358 951 2876951
SGTC_2008 4012253 172 µM 0.899056779731102 0.229762971251044 no 815 0.184311208867598 928 603940
SGTC_1350 1495-0454 146 µM 0.898609593533437 0.229872888371558 no 816 0.184430323457956 951 1069057
SGTC_1988 st071872 53.4 µM 0.897267709824795 0.230202896282853 no 817 0.184788041183656 940 16414116
SGTC_2484 5809818 12.04 µM 0.896513145439321 0.230388581773184 no 818 0.184989381350993 879 2870548
SGTC_622 1348-1566 26.3 µM 0.896121530765267 0.230484984496819 no 819 0.185093929472914 965 7340407
SGTC_2712 st079126 47.7 µM 0.896002947180629 0.230514180343478 no 820 0.185125594593119 867 3152970
SGTC_2264 7948757 110.76 µM 0.89484066430697 0.230800449345747 no 821 0.18543613458618 879 2971411
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.894816608573822 0.230806376343051 no 822 0.185442565236524 885 17037758
SGTC_1983 st071813 46.9 µM 0.894734454961245 0.230826618488808 no 823 0.185464527828898 889 11838595
SGTC_3282 9108498 15.4605 µM 0.894106779663479 0.230981306548416 no 824 0.185632381120591 867 16459645
SGTC_917 harmaline 728.087 nM 0.892145149151486 0.23146511536466 no 825 0.186157568830028 902 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1961 st076550 68.7 µM 0.891894661792867 0.231526935234199 no 826 0.186224698100133 859 1579337
SGTC_709 3807-1509 243 µM 0.891564970184735 0.231608316610882 no 827 0.186313076547356 931 1886677 YPL242C IQG1
SGTC_2022 5136654 200 µM 0.891059978590112 0.231733000102855 no 828 0.186448496984205 893 1713771
SGTC_2765 myclobutanil 7.74 µM 0.890521420999071 0.23186601231009 no 829 0.186592985765568 899 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2113 5491891 107.031 µM 0.889743634352114 0.232058184009689 no 830 0.186801779272199 920 789979
SGTC_1218 1348-1416 30.7 µM 0.888289385057898 0.232417730539236 no 831 0.18719255404623 935 6787668
SGTC_563 tetrahydrosecaminediol 614 µM 0.888032300113396 0.23248132406902 no 832 0.187261688497567 970 334274 A psychoactive constituent of the cannabis plant.
SGTC_96 0929-0093 37.281 µM 0.887085549423692 0.232715599406536 no 833 0.187516421725271 886 6991579
SGTC_3309 9129340 25.759 µM 0.885674595774873 0.233064986037863 no 834 0.187896450789231 968 17158987
SGTC_1841 st054148 70 µM 0.883356258496943 0.233639694994012 no 835 0.188521908153412 870 675442
SGTC_2487 5918373 44.05 µM 0.881118705009339 0.234195122228047 no 836 0.189126787062898 995 2876279
SGTC_2028 5153890 36.43 µM 0.8786521795966 0.23480823324758 no 837 0.189794947244459 911 2830968 YPR165W RHO1
SGTC_376 3970-0862 59.1 µM 0.876787037033845 0.235272445379592 no 838 0.190301160659091 952 3135186
SGTC_1784 st039334 36.3 µM 0.874205063158749 0.235915903792507 no 839 0.191003294602451 934 3496984
SGTC_235 0330-0087 5 mM 0.874196830539499 0.235917957008687 no 840 0.191005535893452 975 46494818 YHR062C RPP1
SGTC_881 0833-0569 170 µM 0.872060426200989 0.236451109279579 no 841 0.191587706824158 897 5418700
SGTC_1001 4048-4355 44.4 µM 0.868767836151397 0.237274091537817 no 842 0.192487064451053 927 21824233
SGTC_897 1000-0139 31.4 µM 0.868117206215781 0.237436902317661 no 843 0.192665086298542 947 6151020
SGTC_2803 7707263 71.43 µM 0.86453890041934 0.238333417119812 no 844 0.193645960201365 900 2199229
SGTC_2557 derrustone 83.84 µM 0.864318309175146 0.238388745027493 no 845 0.19370652746088 1002 629853 An antioxidant.
SGTC_1636 st007707 68.9 µM 0.859808788334883 0.239521347127896 no 846 0.194947227008864 979 403051
SGTC_1221 2958-7315 257 µM 0.859281938303139 0.239653861114971 no 847 0.195092493261874 908 4562705
SGTC_3174 9107204 49.47 µM 0.859084436443503 0.239703547342158 no 848 0.195146966611905 936 3938802
SGTC_1204 4049-0315 18.3 µM 0.858636918663107 0.239816151737714 no 849 0.195270431511583 921 588402
SGTC_134 0269-0018 6.916 µM 0.858203740916686 0.239925175374851 no 850 0.195389985359137 886 4378915
SGTC_1716 st033144 30.6155 µM 0.857337336340133 0.240143316080966 no 851 0.195629239966578 992 674617
SGTC_2341 7987486 176.74 µM 0.853316013407546 0.241157206401939 no 852 0.196742041079531 1002 1258686
SGTC_1207 2099-0101 141 µM 0.85266612478381 0.241321280020691 no 853 0.196922240761471 1023 5837381
SGTC_3223 9129970 49.47 µM 0.849880462954067 0.242025246635331 no 854 0.197695774302939 1013 17248386
SGTC_1342 1486-1464 234 µM 0.848264595576351 0.242434103472468 no 855 0.198145315060958 974 3253938
SGTC_3133 9127736 49.47 µM 0.847043260007858 0.242743381527906 no 856 0.198485504666615 974 27243420
SGTC_2766 oltipraz 83.91 µM 0.846161744096338 0.242966739892437 no 857 0.198731260036934 941 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1682 st012968 530 nM 0.845781357954986 0.243063156401513 no 858 0.198837363473051 888 24207270
SGTC_1481 3346-2004 36 µM 0.845049501155854 0.243248718399443 no 859 0.199041600803336 1010 2770522
SGTC_993 3909-8757 62.7 µM 0.844551156101441 0.243375117399743 no 860 0.199180744944642 899 4288324 YLR208W SEC13
SGTC_2036 5160441 105 µM 0.844258134656829 0.243449455196625 no 861 0.199262587525728 1033 134534 YIL048W NEO1
SGTC_2165 5727197 32.143 µM 0.840023727918735 0.244525067207742 no 862 0.20044754135158 935 1361712
SGTC_303 1348-1668 34.2 µM 0.839761506456418 0.244591760032211 no 863 0.200521060146335 966 5380509
SGTC_1575 cyproterone acetate 48 µM 0.839404290731364 0.2446826292478 no 864 0.200621238447961 958 9880 An androgen receptor antagonist and liver toxin.
SGTC_519 k048-0011 62.8 µM 0.837325806206197 0.245211718503137 no 865 0.201204728702313 964 6836379
SGTC_1709 st033179 39.1045 µM 0.836481612116361 0.245426788116283 no 866 0.201442008489408 1014 573381
SGTC_1714 st033236 13.627 µM 0.835675931699548 0.245632140357807 no 867 0.201668619459906 1002 2916566
SGTC_1188 1403-0014 4.57 µM 0.833355823167893 0.246224005945629 no 868 0.202322040871617 1026 9614867
SGTC_3338 9144300 39.5675 µM 0.832196994781409 0.246519912119002 no 869 0.202648879951074 989 4901274
SGTC_1631 benzylvanillin 81.9 µM 0.831072276425177 0.246807290409726 no 870 0.202966400107223 971 75506
SGTC_2737 bleomycin 30.5 nM 0.830838941568628 0.246866932565718 no 871 0.203032310255744 1048 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1158 4092-0494 91.8 µM 0.829432517730629 0.247226588474475 no 872 0.203429853712304 1034 1148199
SGTC_2420 aureobasidin a 50 nM 0.828881894410301 0.247367472189054 no 873 0.203585620754653 1017 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2795 7780010 54.55 µM 0.826600147135452 0.247951742230936 no 874 0.204231866974754 942 953673
SGTC_828 2074-0507 139 µM 0.825901053021857 0.24813090133052 no 875 0.204430111611422 1026 X828
SGTC_1160 4092-0570 10.5 µM 0.825353468201058 0.248271280864928 no 876 0.204585472177721 987 4994975
SGTC_530 4358-1714 28 µM 0.825182977906224 0.248314996614611 no 877 0.20463385796018 1030 1564641
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.82432291130601 0.248535590525629 no 878 0.204878051858627 960 4620898
SGTC_1729 st035615 45.989 µM 0.822112191474031 0.249103085076103 no 879 0.205506523741409 950 17385451
SGTC_2919 7978188 46.38 µM 0.821317005034346 0.249307378864644 no 880 0.20573286200464 1017 2980291
SGTC_2220 6782180 200 µM 0.821298289799149 0.249312188125826 no 881 0.205738190805585 950 833803
SGTC_2986 9022445 71.43 µM 0.82119843793532 0.249337847931211 no 882 0.205766623075225 1002 6459286
SGTC_1738 st035555 74 µM 0.819854153440206 0.249683437096111 no 883 0.206149627643926 1010 5331140
SGTC_2634 4'-methoxyflavone 100 µM 0.819590227109876 0.2497513172402 no 884 0.206224873380383 957 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_543 3844-1095 191 µM 0.819246080048087 0.249839844354677 no 885 0.206323014602285 1016 4230703
SGTC_2066 5222451 176 µM 0.818652772631155 0.249992503661748 no 886 0.206492274443284 1079 2281147
SGTC_1555 citronellol 128 µM 0.815813802591066 0.250723661462335 no 887 0.207303318872208 991 8842 A terpine precursor.
SGTC_2481 5478948 45.16 µM 0.815583801049925 0.25078294637442 no 888 0.207369108698314 986 77792
SGTC_2194 5927483 104.545 µM 0.814600510750048 0.251036481733409 no 889 0.207650509006211 1065 760979
SGTC_1268 0828-0275 2.46 µM 0.814432067298518 0.25107992744374 no 890 0.207698737170323 1047 745337
SGTC_1995 st072814 61.1 µM 0.814128643235855 0.251158198009712 no 891 0.207785629224424 973 5769371
SGTC_247 mechlorethamine 29.705 µM 0.813241140041356 0.251387210329893 no 892 0.208039908208063 978 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1349 flufenamic acid 69 µM 0.809683799155182 0.252306257304989 no 893 0.209060965795543 969 3371 A non-steroidal anti-inflammatory.
SGTC_1319 1306-0155 43.7 µM 0.80964118261298 0.25231727811165 no 894 0.209073215812053 1051 3122360
SGTC_1710 st031758 61.5 µM 0.809231528536385 0.252423229222519 no 895 0.209190991391611 1011 5394341
SGTC_2480 5767542 37.17 µM 0.808502564915176 0.252611823106387 no 896 0.209400665054953 1051 2867358
SGTC_3081 9117243 49.47 µM 0.80790060916196 0.252767614072406 no 897 0.209573900305736 1038 45595589
SGTC_136 0097-0015 404.482 µM 0.807579404246424 0.252850765169301 no 898 0.209666373498236 1119 4861337
SGTC_359 0081-0058 15.9 µM 0.806523242178407 0.253124277889423 no 899 0.209970606072988 976 3494159
SGTC_635 k038-0028 24.7 µM 0.806017376341573 0.253255336311062 no 900 0.21011641500019 1029 4035102
SGTC_1779 st039427 55 µM 0.803941460760548 0.253793532595369 no 901 0.210715391910708 1110 1124498
SGTC_581 0958-0271 211 µM 0.80331521796644 0.253956008428282 no 902 0.210896282135246 1098 4591145
SGTC_786 4544-0069 423 µM 0.802921988872255 0.254058057811042 no 903 0.211009912878603 1038 748821 YLR208W SEC13
SGTC_2147 5545932 89.7195 µM 0.80207607866195 0.254277658242259 no 904 0.211254475727397 1009 797404
SGTC_728 3030-5151 22.5 µM 0.801473617323152 0.254434119385779 no 905 0.211428755780037 1000 3125388
SGTC_1327 1436-0082 2.18 µM 0.800698890851762 0.254635392464757 no 906 0.21165299241302 1009 15992205
SGTC_3126 9127922 49.47 µM 0.799702729534542 0.254894316567159 no 907 0.211941525565654 1062 45595682
SGTC_182 3448-4371 550.524 µM 0.799662960122061 0.254904656366378 no 908 0.21195304935142 1091 3491403
SGTC_2844 9010103 25.97 µM 0.799245553521665 0.255013192720107 no 909 0.212074021303464 994 2480525
SGTC_619 1652-1634 108 µM 0.798767218985905 0.255137601612785 no 910 0.21221270090035 960 5400454
SGTC_2926 9010726 65.15 µM 0.797053260010472 0.255583641633517 no 911 0.212710050008831 1034 2994293
SGTC_131 0141-0277 33.849 µM 0.796731956424262 0.2556673028648 no 912 0.212803360166999 1012 1547771
SGTC_2583 asiatic acid 100 µM 0.796239751175523 0.255795491306878 no 913 0.212946348409584 1045 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_409 arachidonic acid 100 µM 0.79233156707929 0.256814516488844 no 914 0.214083685015464 1076 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1572 epiandrosterone 68.9 µM 0.789486578603887 0.257557649304714 no 915 0.21491383555351 1049 441302 A steroid.
SGTC_78 0336-0123 156.75 µM 0.786450588175785 0.258351903339215 no 916 0.215801778119273 945 6765896
SGTC_1914 st062367 72.6 µM 0.786052101503261 0.25845624670724 no 917 0.215918482015941 1005 978205
SGTC_1415 3966-0071 78.1 µM 0.782294456683874 0.259441254966424 no 918 0.217020771931881 1051 2893185
SGTC_900 1112-0045 141 µM 0.779953486947691 0.260055882663414 no 919 0.217709126859297 975 56211 YIL048W NEO1
SGTC_3171 9103192 49.47 µM 0.779848813911233 0.260083382366024 no 920 0.217739935035554 1137 13018434
SGTC_3281 9140613 49.47 µM 0.77923670443639 0.260244225794531 no 921 0.217920146173301 1032 16013766
SGTC_2508 celastrol 40.54 µM 0.776912639013999 0.260855384709098 no 922 0.218605156935203 1046 122724 Celastrol is a natural product and antioxidant.
SGTC_1760 st045453 10.4495 µM 0.776444777466354 0.260978507356949 no 923 0.218743207353588 1099 3323419 YIL048W NEO1
SGTC_1124 fisetin 1.16336 µM 0.775987715324362 0.261098816877438 no 924 0.21887811966098 1015 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1242 0402-0103 60.1 µM 0.774643292360932 0.261452865849807 no 925 0.219275234119605 1039 432868
SGTC_779 1360-0071 233 µM 0.774179175206532 0.261575146655604 no 926 0.219412420726341 1138 7566
SGTC_3207 9114163 49.47 µM 0.773367213882607 0.261789144439768 no 927 0.219652543820903 1109 849233
SGTC_2983 9022671 12.99 µM 0.77325895659147 0.26181768314954 no 928 0.219684570382933 1037 6405161
SGTC_1175 0741-0056 27.6 µM 0.772559365725288 0.262002147263763 no 929 0.219891600206931 1150 765927
SGTC_1984 st072354 53.1 µM 0.772538762004577 0.262007580944713 no 930 0.21989769915992 1059 5762938
SGTC_1076 itraconazole 331 nM 0.77044501023668 0.262560053101056 no 931 0.220517981255617 1135 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1305 1181-0477 144 µM 0.770394620624106 0.262573356604291 no 932 0.220532921718693 1068 6252086
SGTC_2403 6032726 181.2 µM 0.770040838257409 0.262666769393875 no 933 0.220637834120141 1071 2881040
SGTC_1581 himbacine 57.9 µM 0.769641508303784 0.262772229004235 no 934 0.220756287773674 1054 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1881 5652484 16 µM 0.76645248431642 0.263615199207078 no 935 0.22170355703879 1049 2255129
SGTC_773 4358-1457 44.6 µM 0.76604691232692 0.263722504828209 no 936 0.221824194583802 1131 1186886
SGTC_103 0844-0104 51.839 µM 0.765942003433862 0.263750265090015 no 937 0.221855405877293 1166 5375804
SGTC_766 1391-0721 126 µM 0.765345013817383 0.263908264695749 no 938 0.222033063137543 1099 1020919 YIL115C NUP159
SGTC_2935 9038016 29.96 µM 0.764732347784599 0.264070463380866 no 939 0.22221546993585 1102 6463195
SGTC_1237 0330-0133 46.1 µM 0.762923150644175 0.264549730869617 no 940 0.222754614342978 1045 X1237 YHR072W ERG7
SGTC_1973 st070275 50.2 µM 0.762831782654328 0.264573946548017 no 941 0.22278186194856 1062 17118334
SGTC_2196 6573537 42.6665 µM 0.762746354718369 0.264596588926667 no 942 0.222807339839428 1101 2903087
SGTC_1300 1094-0077 113 µM 0.761005966982724 0.265058087172606 no 943 0.223326751617654 1033 5532636
SGTC_1888 azatryptophan 97.5 µM 0.760778238107425 0.265118504228984 no 944 0.22339476733718 1012 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2380 9035439 200 µM 0.760039595360788 0.265314516174493 no 945 0.223615458654921 1151 6462575
SGTC_460 trequinsin 123 µM 0.758391642663444 0.265752094616368 no 946 0.224108279764736 1141 5537 A vasodilator.
SGTC_157 1348-1695 65.819 µM 0.755610947924533 0.266491276949503 no 947 0.224941245019434 1092 5380510
SGTC_3236 9132701 49.47 µM 0.755013938650117 0.266650113330087 no 948 0.225120309445856 1089 24282524
SGTC_294 k038-0071 157 µM 0.754175768346695 0.266873192175205 no 949 0.22537184291621 1107 24152826
SGTC_2731 amoxapine 43.43 µM 0.749417950555194 0.268141268436691 no 950 0.22680266750516 1130 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_652 0437-0092 114 µM 0.748401819991999 0.268412484844849 no 951 0.227108912545444 1101 3091274
SGTC_2251 lansoprazole 556 µM 0.747300419183819 0.268706616533977 no 952 0.227441119757388 950 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2732 terfenadine 20 µM 0.746514889486154 0.268916492982523 no 953 0.227678220280105 1115 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_3325 9138760 55.175 µM 0.745561261821403 0.269171392111801 no 954 0.227966245588191 1104 43844959
SGTC_2296 7971656 126.45 µM 0.742039805540627 0.270113705913828 no 955 0.229031609283905 1141 666570
SGTC_269 exalamide 29 µM 0.73950871194138 0.270792024327575 no 956 0.229799075788377 1069 3316 A derivative of salicylamide.
SGTC_38 0929-0051 58.268 µM 0.73946561161178 0.270803582325036 no 957 0.229812156928139 1143 1379719
SGTC_1509 1326-1131 80 µM 0.738298540920278 0.271116643352262 no 958 0.230166526474736 1095 768313
SGTC_2130 NSC 7 2.4545 µM 0.737956116190986 0.271208531351289 no 959 0.230270558350827 1138 21448
SGTC_2312 7706453 155.7 µM 0.735179486477645 0.27195419923462 no 960 0.231115095221231 1122 976098
SGTC_149 3970-0822 46.1 µM 0.734127734541766 0.272236914769243 no 961 0.231435445828894 1196 3114250 YBL034C STU1
SGTC_2545 solidagenone 89.61 µM 0.73375359411672 0.272337520564696 no 962 0.231549464043139 967 6708572 An anti ulcer agent
SGTC_1126 isoteolin 1.0172 µM 0.732896177778329 0.272568148167641 no 963 0.231810877261685 1148 133323
SGTC_2365 9042475 200 µM 0.732057164989223 0.272793919407474 no 964 0.232066838588455 1172 6464479
SGTC_1189 1431-2119 7.28 µM 0.730952834788483 0.273091226664292 no 965 0.232403981172097 1175 3107275
SGTC_2418 pentamidine 31.67 µM 0.730432403413674 0.273231392607011 no 966 0.232562958824966 1149 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_658 3253-0951 102 µM 0.730277569409202 0.273273100380083 no 967 0.232610268076422 1168 1184878
SGTC_1254 0550-0035 264 µM 0.727790734633902 0.273943413035018 no 968 0.233370848574447 1167 15121435
SGTC_3205 9113483 49.47 µM 0.726915465080721 0.274179530350209 no 969 0.23363887138356 1141 17018033
SGTC_228 caffeine 993.056 µM 0.724647758809636 0.27479174592312 no 970 0.234334075877126 1122 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2828 7998861 71.43 µM 0.723473599702877 0.275108999748438 no 971 0.234694483985015 1075 2988188
SGTC_3104 9120930 49.47 µM 0.722401306989211 0.275398887120001 no 972 0.235023891793076 1142 17014836
SGTC_2250 alverine citrate 130 µM 0.722098426453044 0.275480796119327 no 973 0.235116982791056 1119 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.721723096572741 0.27558231446077 no 974 0.235232369504227 1195 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1671 st016596 74.5 µM 0.721455877708854 0.275654602398741 no 975 0.235314538973164 1202 2829167
SGTC_1016 4226-1401 38 µM 0.720064806274213 0.27603106498454 no 976 0.23574254755151 1171 2901613
SGTC_48 0382-0018 55 µM 0.719582438111034 0.276161666138641 no 977 0.235891064054765 1259 762596
SGTC_969 1313-0238 134 µM 0.716092778797408 0.27710739359276 no 978 0.236967031190604 1188 5212874
SGTC_1618 st003135 44.5 µM 0.714865771527779 0.277440299227326 no 979 0.237345994544559 1129 1270615
SGTC_1863 st057641 20.1 µM 0.713141964444384 0.27790832417839 no 980 0.237878957110387 1194 3921635
SGTC_1767 st044992 70.3 µM 0.712842355677446 0.277989709220633 no 981 0.237971656331302 1156 9600693
SGTC_1474 0330-0125 5.35 µM 0.711797821015771 0.278273535151634 no 982 0.238294991110854 1184 X1474
SGTC_19 0279-0214 38.434 µM 0.711748147361574 0.278287036231655 no 983 0.238310373538134 1240 3566274 YBR002C RER2
SGTC_3020 9089140 49.47 µM 0.711506071182381 0.278352836038652 no 984 0.238385344987125 1184 17217859
SGTC_211 3455-0679 143.504 µM 0.711388625018871 0.278384762336392 no 985 0.238421722938063 1194 748649
SGTC_3218 9131285 49.47 µM 0.711130670876398 0.278454890266913 no 986 0.238501632710113 1185 17156417
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.710909031639608 0.278515152428674 no 987 0.23857030445636 1202 1377
SGTC_2768 sulfasalazine 50.2 µM 0.71016274316804 0.278718109754261 no 988 0.238801610812338 1202 5384001 An antioxidant and salicylic acid derivative.
SGTC_1519 esterone 74 µM 0.710020972700971 0.278756673162442 no 989 0.238845565336766 1154 698 A steroid.
SGTC_1615 st002656 86.5 µM 0.708186052040787 0.27925602962088 no 990 0.239414863337421 1185 1584458
SGTC_1165 k072-0275 30.3 µM 0.70705812580076 0.279563199765122 no 991 0.23976517841453 1198 6153523 YGL055W OLE1
SGTC_305 1682-2595 20.8 µM 0.706972038238263 0.279586650878991 no 992 0.23979192725834 1179 226033
SGTC_2876 9059903 25.97 µM 0.706427678267076 0.279734962092396 no 993 0.239961106686289 1168 6916095
SGTC_335 4077-0256 27.6 µM 0.706319156959749 0.279764533353273 no 994 0.239994841363261 1204 3121989
SGTC_1064 honokiol 6.76 µM 0.706314206957768 0.2797658822287 no 995 0.239996380170838 1177 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_34 0469-0683 81.75 µM 0.705790994506744 0.27990847539994 no 996 0.240159061608972 1181 3690923
SGTC_1711 st032263 62.8 µM 0.705512591489949 0.279984364045708 no 997 0.240245649415487 1176 3958979
SGTC_1233 0325-0408 14.2 µM 0.704931204281074 0.28014287397003 no 998 0.240426525012277 1176 12874
SGTC_2839 9003951 25.97 µM 0.700169220017242 0.281442819761187 no 999 0.241910815736746 1181 2990634
SGTC_2891 9063876 19.48 µM 0.699689923146046 0.281573821215449 no 1000 0.242060485447444 1152 6472478
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.699280159518772 0.281685841152845 no 1001 0.242188481865079 1271 688801
SGTC_462 ag-879 158 µM 0.6984136033237 0.28192280839837 no 1002 0.242459285761352 1201 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2888 9058547 12.99 µM 0.697847333645538 0.282077711579243 no 1003 0.242636336935868 1117 16476514
SGTC_1038 k292-0204 154 µM 0.695451955419125 0.282733420717692 no 1004 0.243386055134567 1169 4454212
SGTC_696 1560-0013 611 µM 0.692573236778923 0.283522406730077 no 1005 0.244288705335125 1236 1650269
SGTC_580 1123-0028 41 µM 0.692406167360768 0.283568228725216 no 1006 0.244341146919738 1263 1677248 YPR107C YTH1
SGTC_2025 5147754 141 µM 0.68925089443326 0.284434288531002 no 1007 0.245332697041339 1219 315777 YLR208W SEC13
SGTC_1933 st074711 15.9 µM 0.688211101635396 0.284719967610105 no 1008 0.245659926943558 1218 17250958
SGTC_1380 2291-0730 164 µM 0.687040528063201 0.28504174198728 no 1009 0.246028594735755 1199 2999191
SGTC_3260 9137109 49.47 µM 0.686274190570036 0.285252491362699 no 1010 0.24627011054982 1098 17478346
SGTC_3346 9158254 43.5805 µM 0.685521181756686 0.285459647525481 no 1011 0.246507549507083 1173 17639500
SGTC_1895 st058434 18.3 µM 0.68484326628229 0.28564620641646 no 1012 0.246721414881963 1219 5393175
SGTC_3047 9092122 49.47 µM 0.682978046737828 0.286159804534419 no 1013 0.247310357372633 1181 17173831
SGTC_2639 lactacystin 53 µM 0.681710925068375 0.286508963251567 no 1014 0.247710878948584 1230 3870 A proteasome inhibitor.
SGTC_257 daunorubicin 18.5 µM 0.679560868236113 0.287101879112642 no 1015 0.248391277210414 1257 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1913 st060213 96.1 µM 0.67947709762218 0.287124992082216 no 1016 0.248417807065862 1242 688959
SGTC_175 3793-3120 23.7 µM 0.679019577030187 0.287251241145096 no 1017 0.248562728853854 1220 5322297
SGTC_809 3998-0021 90 µM 0.678585982116305 0.287370912353945 no 1018 0.248700113630239 1166 715485
SGTC_69 0096-0274 206.684 µM 0.677450162556752 0.287684507726754 no 1019 0.249060190282881 1348 6741392
SGTC_1842 st055362 61.2 µM 0.675464265772761 0.288233194346642 no 1020 0.249690423582578 1220 676032
SGTC_3344 9148862 3.898 µM 0.675297776618056 0.288279216319625 no 1021 0.249743298119252 1262 4905352
SGTC_2100 5377183 190 µM 0.675098840120953 0.288334212133793 no 1022 0.249806485256245 1249 2844202
SGTC_798 1287-0182 476 µM 0.674490759476595 0.288502346139933 no 1023 0.249999679274407 1260 1649755
SGTC_1712 st032288 53.4 µM 0.674490759476595 0.288502346139933 no 1024 0.249999679274407 1231 2883011
SGTC_3130 9127414 49.47 µM 0.67390192995027 0.288665201238982 no 1025 0.250186832527424 1244 1494646
SGTC_806 3966-4455 5.86 µM 0.673884499367641 0.288670022749466 no 1026 0.250192373786363 1161 714982
SGTC_1123 mangostin 811.285 nM 0.673255720355183 0.288843976004387 no 1027 0.250392308918529 1206 5281650 An antioxidant.
SGTC_2716 st080858 38.6235 µM 0.67109511032787 0.28944208981462 no 1028 0.251079970855529 1215 5296050
SGTC_912 3474-0017 2.18 µM 0.668353154694765 0.290201971961142 no 1029 0.251954095314172 1275 3360550
SGTC_1527 coumarin 137 µM 0.665341534882648 0.291037661966 no 1030 0.252916035164309 1276 323 A hepatotoxic, DNA x-linker.
SGTC_827 3253-0474 693 µM 0.664910468725447 0.291157369799725 no 1031 0.253053879733289 1247 5402065
SGTC_107 0358-0022 2.6945 µM 0.663963637501512 0.291420387184817 no 1032 0.253356792238654 1235 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_717 1532-0246 73.2 µM 0.661249493241905 0.292174954739756 no 1033 0.254226162887056 1235 9561992
SGTC_895 0964-0006 13.7 µM 0.660495911765772 0.292384621366244 no 1034 0.254467820579666 1235 6738897
SGTC_2112 5488546 200 µM 0.660136695387139 0.292484589635679 no 1035 0.254583056048067 1233 600757
SGTC_1377 2944-0135 198 µM 0.659031163751369 0.292792353656169 no 1036 0.254937878516173 1318 1894137
SGTC_1351 1496-0003 46.5 µM 0.657863972660319 0.293117445854374 no 1037 0.255312771346387 1255 3891978
SGTC_1859 st055998 20 µM 0.657626427141614 0.293183628776811 no 1038 0.255389104423194 1277 676301
SGTC_3159 9100096 49.47 µM 0.657286138216239 0.293278449267968 no 1039 0.255498473929954 1221 25236875
SGTC_3180 9109287 49.47 µM 0.6543440783804 0.29409883749482 no 1040 0.256445076916569 1242 18891271
SGTC_153 4077-0274 519.67 µM 0.653811717029155 0.294247398772756 no 1041 0.256616558350252 1370 3121976
SGTC_2006 4011487 200 µM 0.653199928710922 0.294418167813522 no 1042 0.256813698099648 1296 45595294
SGTC_972 1319-0219 195 µM 0.65288760550846 0.294505364515706 no 1043 0.256914370022444 1231 23903702
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.65244661447439 0.294628503945427 no 1044 0.257056550728759 1281 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_302 1094-0063 18.9 µM 0.652283480526595 0.294674062411269 no 1045 0.257109157404005 1213 5440289
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.652174261029097 0.294704565988432 no 1046 0.257144381127287 1280 5282362
SGTC_2575 plumbagin 510 nM 0.651222776729829 0.294970364689073 no 1047 0.257451344720265 1239 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2052 5265182 7.135 µM 0.651082361373179 0.295009599300425 no 1048 0.257496661006875 1275 1239884
SGTC_1816 st051957 91.6 µM 0.650735211382863 0.295106609656422 no 1049 0.257608714600921 1267 674121
SGTC_760 0568-0725 82.9 µM 0.650080864088358 0.295289505603833 no 1050 0.257819994626825 1270 3916171
SGTC_2956 9076196 2.52 µM 0.650035394677946 0.295302216650763 no 1051 0.25783467943471 1309 16423868
SGTC_2389 9091542 195.52 µM 0.647845180541687 0.295914792495303 no 1052 0.258542545002593 1268 3626624 YOL127W RPL25
SGTC_2642 cholecalciferol 100 µM 0.647186616105944 0.296099098875425 no 1053 0.258755586166691 1260 9821465 A vitamin D precursor, similar to steriods.
SGTC_1629 st005085 44.9 µM 0.642846674464004 0.297314993722997 no 1054 0.260161796914101 1272 24207091
SGTC_686 1319-0111 510 µM 0.640355338000784 0.298014005242725 no 1055 0.260970805853332 1358 4562600
SGTC_1395 3486-0190 4.35 µM 0.639871807646782 0.298149759445582 no 1056 0.261127971898758 1318 6748079
SGTC_1736 st036774 51 µM 0.639620102676666 0.298220438353613 no 1057 0.261209804987511 1306 1272247
SGTC_2959 9079155 11 µM 0.637022026116128 0.298950425241829 no 1058 0.262055248262285 1285 16189457
SGTC_670 4204-0025 119 µM 0.636997944960567 0.29895719516811 no 1059 0.26206309109601 1302 719039
SGTC_331 k048-0133 24.5 µM 0.635326989736071 0.299427120128398 no 1060 0.262607587200311 1259 6813582
SGTC_1665 st014639 11.4 µM 0.627884534292815 0.301524227570203 no 1061 0.26503979155343 1353 981133 YIL048W NEO1
SGTC_2438 5259590 200 µM 0.626842708285669 0.301818315977727 no 1062 0.265381172538326 1303 1201127
SGTC_2151 5563267 85.4165 µM 0.625382969224941 0.302230590299962 no 1063 0.265859868539374 1300 5310824
SGTC_2128 5255449 168.493 µM 0.62205309976629 0.303171990231942 no 1064 0.266953476398489 1288 736008
SGTC_67 0335-0847 266 µM 0.617647360587286 0.304419564333745 no 1065 0.268403909009987 1458 4552207 YOR254C SEC63
SGTC_1460 k062-0059 9.15 µM 0.617620818963907 0.304427087051578 no 1066 0.268412658887718 1279 1373085
SGTC_2681 menadione 3.18 µM 0.617551503565435 0.30444673357181 no 1067 0.268435510512359 1324 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_535 2293-4129 48.2 µM 0.61620190349593 0.304829372010742 no 1068 0.268880636147659 1341 396118 YIL048W NEO1
SGTC_1468 k284-1086 134 µM 0.615320472970885 0.305079390397544 no 1069 0.26917154986246 1331 15996457
SGTC_2851 9015922 71.43 µM 0.613871871359704 0.305490484905826 no 1070 0.269649999592966 1355 2996893
SGTC_2202 7226349 200 µM 0.612634468879015 0.305841838166738 no 1071 0.270059030773644 1282 844334
SGTC_548 1436-0017 110 µM 0.612430722994348 0.305899707779762 no 1072 0.270126410011658 1388 9677137
SGTC_1565 sinapyl alcohol 95.1 µM 0.61020907841265 0.306531032153537 no 1073 0.270861658359729 1286 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1774 st048371 48.465 µM 0.606818755460004 0.307495566795282 no 1074 0.271985599916965 1296 4242727
SGTC_780 0109-0199 192 µM 0.601707942712246 0.308952091942761 no 1075 0.273684281006601 1416 610414
SGTC_826 1683-5028 118 µM 0.599634079055968 0.309543979800356 no 1076 0.274375064995043 1358 722377
SGTC_399 oxolinic acid 75 µM 0.597425958094732 0.31017472857636 no 1077 0.275111513587672 1314 4628 A DNA gyrase inhibitor.
SGTC_3225 9130819 49.47 µM 0.597166399474605 0.310248908125161 no 1078 0.275198145017081 1376 4547121
SGTC_585 0kpi-0023 191 µM 0.59704367361551 0.310283984774469 no 1079 0.275239111216986 1344 64601
SGTC_1495 4469-0029 237 µM 0.595636561247531 0.310686279088281 no 1080 0.275709023273434 1339 793680
SGTC_2470 5664817 21.68 µM 0.593800312300196 0.311211604386163 no 1081 0.276322840078592 1378 2859561
SGTC_1011 4112-3381 17.4 µM 0.592830177734861 0.311489301814933 no 1082 0.27664740472682 1392 2877139
SGTC_2335 9018011 154.17 µM 0.592711625579941 0.311523244289193 no 1083 0.276687079906101 1398 6458208
SGTC_2879 9041815 71.43 µM 0.589954423190866 0.312313105760178 no 1084 0.277610602906888 1307 4942971
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.589662707658955 0.312396724673663 no 1085 0.277708400846964 1335 91467 include heat shock
SGTC_2757 clomiphene 4.22 µM 0.586021416871012 0.313441295755929 no 1086 0.278930561343094 1435 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2027 5150920 200 µM 0.584476944827236 0.313884808889183 no 1087 0.279449736082504 1354 786715
SGTC_1609 st001574 46.4 µM 0.5839250391086 0.314043360321738 no 1088 0.279635373107957 1329 3960012
SGTC_3019 9081971 49.47 µM 0.581947336802248 0.314611796258572 no 1089 0.280301077061887 1437 16451803
SGTC_730 1436-0052 41.2 µM 0.580733361750968 0.314960937755431 no 1090 0.280710086628435 1369 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3184 9108758 49.47 µM 0.577953667957397 0.315761005536678 no 1091 0.281647700162229 1373 902885
SGTC_2593 nobiletin 86.24 µM 0.576829944269314 0.316084687763198 no 1092 0.282027169559493 1319 72344 An anti-infammatory.
SGTC_754 3474-0146 171 µM 0.576748273382713 0.316108218098192 no 1093 0.282054758534089 1298 24762078
SGTC_2661 dactinomycin 12.96 µM 0.575602524159932 0.316438400300028 no 1094 0.282441937267643 1369 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2700 st077718 96.8 µM 0.575008529510312 0.316609635405962 no 1095 0.282642764208073 1372 904970
SGTC_1403 3909-7815 62.9 µM 0.57401405677496 0.316896407195757 no 1096 0.282979144556361 1386 6615483
SGTC_2336 9001819 198.65 µM 0.573861737697151 0.316940340509786 no 1097 0.28303068344428 1476 2989602
SGTC_935 2996-0153 430 µM 0.570016108707245 0.318050387160471 no 1098 0.284333386217123 1400 23738523
SGTC_2433 5607874 27.82 µM 0.568802142994208 0.318401140534926 no 1099 0.284745210095074 1353 2252428
SGTC_2274 7947094 46.08 µM 0.565549851501782 0.319341633048642 no 1100 0.285849913276072 1370 2971028
SGTC_2893 9048488 25.97 µM 0.564116175028464 0.319756591242314 no 1101 0.286337535330125 1312 6467338
SGTC_499 genistein 192 µM 0.563718868113423 0.319871626297963 no 1102 0.286472737206835 1418 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1343 1487-0095 224 µM 0.563258238727199 0.320005017239493 no 1103 0.286629525363105 1402 4560101 YGL055W OLE1
SGTC_1411 3909-8223 150 µM 0.561822782721727 0.320420851668021 no 1104 0.287118383992663 1427 X1411
SGTC_2674 ligustilide 100 µM 0.561161813820139 0.320612402325459 no 1105 0.287343616096936 1368 5319022 A signalling regulator.
SGTC_2985 9022375 71.43 µM 0.560341262872398 0.320850266789783 no 1106 0.287623343706257 1402 4939335
SGTC_2098 5376439 882.5 nM 0.559368970330399 0.321132213909977 no 1107 0.287954966875631 1488 2844116
SGTC_2624 nerol 100 µM 0.558139069749231 0.321489010412152 no 1108 0.288374711719795 1423 637566 A natural product oil.
SGTC_3139 9095020 49.47 µM 0.557884620897291 0.321562847088528 no 1109 0.288461586927634 1238 25236292
SGTC_1928 4'-methoxychalcone 40.3 µM 0.554452712179029 0.322559415705538 no 1110 0.28963452986185 1544 641818
SGTC_2139 5578692 56.4705 µM 0.553055571564011 0.322965487799186 no 1111 0.290112678955262 1401 650991 YMR113W FOL3
SGTC_1006 4099-6547 255 µM 0.552583637269821 0.323102700921622 no 1112 0.290274274483112 1436 3146833
SGTC_727 3032-0951 202 µM 0.549849662267639 0.323898067096393 no 1113 0.291211246321233 1417 3652836
SGTC_1906 st060206 94.7 µM 0.549059286296663 0.324128152857337 no 1114 0.29148238219755 1399 5133468
SGTC_931 2812-0076 566 µM 0.548467933960186 0.324300344944154 no 1115 0.291685320644586 1418 3450959
SGTC_2079 5212404 121 µM 0.54640739359661 0.32490063388268 no 1116 0.292392964462344 1484 758462
SGTC_1505 k297-0037 20.6 µM 0.538128235047661 0.327317141040947 no 1117 0.295244260377735 1399 4089396
SGTC_443 clozapine 122 µM 0.534052439324707 0.328509449278098 no 1118 0.296652626911034 1401 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2608 thymoquinone 42.66 µM 0.533721820596858 0.328606243270979 no 1119 0.29676700500355 1351 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1247 0448-0043 5.84 µM 0.533558825934505 0.328653966834166 no 1120 0.296823400704012 1454 3089013 YGL099W LSG1
SGTC_2621 lithochol-11-enic acid 100 µM 0.533257025038718 0.328742339155256 no 1121 0.296927835923614 1502 6708711
SGTC_1725 st036284 20.55 µM 0.533217556717541 0.328753896844266 no 1122 0.296941494789377 1589 707914
SGTC_2054 5233173 129 µM 0.532334972828236 0.329012390685469 no 1123 0.297247007081044 1467 6889
SGTC_1417 3966-0327 90.4 µM 0.532330739023784 0.329013630892147 no 1124 0.297248472986805 1474 651118
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.532169874143857 0.329060754372623 no 1125 0.297304173035941 1457 368090
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.531954042776739 0.32912398390855 no 1126 0.297378912921777 1409 689007
SGTC_1200 1643-0193 18.4 µM 0.526103094034706 0.330839923892157 no 1127 0.299408289522658 1430 5403974
SGTC_2506 ethyl hematommate 54.16 µM 0.526098245470239 0.330841347338637 no 1128 0.299409973827942 1387 3940691 An allergen.
SGTC_1436 4092-1007 8.32 µM 0.52586311108235 0.330910381266029 no 1129 0.299491660498886 1419 2881121
SGTC_1924 st058459 75.1 µM 0.525303335416415 0.33107475089704 no 1130 0.299686169550919 1422 688683
SGTC_613 3914-0030 117 µM 0.524297756757523 0.331370105580381 no 1131 0.300035728447607 1356 1145395
SGTC_363 0455-0021 3.06 µM 0.523578255662005 0.331581499067196 no 1132 0.30028595431584 1469 4597466
SGTC_1400 3771-8998 51.5 µM 0.52230351414993 0.331956157030097 no 1133 0.300729511412473 1478 670767
SGTC_2592 piperlongumine 83.33 µM 0.522299633310098 0.331957297900551 no 1134 0.300730862234859 1382 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3149 9097855 49.47 µM 0.521810922362483 0.332100979221009 no 1135 0.300900992057555 1563 25236625 YMR079W SEC14
SGTC_1299 1079-1439 3.74 µM 0.520743189178266 0.332414979304935 no 1136 0.301272841745726 1399 323161
SGTC_2203 7227154 166.4 µM 0.520112427397607 0.33260052967961 no 1137 0.30149260858601 1446 896304
SGTC_3113 9123498 49.47 µM 0.519766430487705 0.332702328566442 no 1138 0.301613189715766 1478 8897275
SGTC_564 3555-0129 330 µM 0.519683299901258 0.332726789008058 no 1139 0.301642164246714 1404 563260
SGTC_973 1325-0077 65.9 µM 0.519670733545007 0.33273048660947 no 1140 0.30164654426312 1561 2835149
SGTC_1690 st023502 41.2 µM 0.519149038844007 0.33288400759976 no 1141 0.301828406724807 1522 24207482
SGTC_562 3772-2733 112 µM 0.516998475764954 0.333517157172301 no 1142 0.302578611423495 1448 2876874 YIL048W NEO1
SGTC_265 mycophenolic acid 32.932 µM 0.515776576378576 0.333877109402956 no 1143 0.303005232061935 1512 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2099 5377090 177.372 µM 0.51556743493848 0.3339387344978 no 1144 0.303078279818494 1434 2243829
SGTC_3138 9097216 49.47 µM 0.515062724836124 0.334087469559063 no 1145 0.303254594586621 1431 25237486
SGTC_1428 4049-0204 61.7 µM 0.513026611162557 0.334687764567652 no 1146 0.30396635302882 1538 X1428
SGTC_2563 tomatine 8.54 µM 0.512819275712103 0.334748915759304 no 1147 0.304038872457499 1576 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_552 k242-0005 476 µM 0.511829299493601 0.335040958187755 no 1148 0.304385241315211 1460 4088318
SGTC_2786 7743617 45.45 µM 0.511784618866114 0.335054141301943 no 1149 0.304400878133858 1368 583674
SGTC_3034 9090421 49.47 µM 0.50927588058592 0.335794675481244 no 1150 0.305279430868162 1447 17173761
SGTC_3335 9143315 29.6265 µM 0.504401756158962 0.337235250939979 no 1151 0.306989542107923 1463 4899691
SGTC_2651 TUB2.036 5 µM 0.504113871322416 0.337320411898919 no 1152 0.307090679915663 1549 15992207 YFL037W TUB2
SGTC_2439 5492030 7.2 µM 0.503608015515439 0.337470072360324 no 1153 0.30726842940503 1489 5722370
SGTC_1444 4112-3581 28 µM 0.497550343390533 0.339264262662004 no 1154 0.30940050540296 1490 2877249
SGTC_691 1548-0686 185 µM 0.496446142622508 0.339591704675919 no 1155 0.309789838344018 1445 46495133
SGTC_2794 7785382 27.27 µM 0.495434297455278 0.339891865720014 no 1156 0.310146794843811 1512 2205081
SGTC_3301 9125354 19.7965 µM 0.492647322506212 0.340719138553293 no 1157 0.311130902305513 1465 41905162
SGTC_2749 bexarotene 57.39 µM 0.49036728467228 0.341396504949643 no 1158 0.311937011252568 1465 82146 An retinoic acid receptor inhibitor.
SGTC_1679 SEC14.276 6.7 µM 0.489036673408079 0.341792046781497 no 1159 0.312407866684983 1587 1005053 YMR079W SEC14
SGTC_49 0717-0965 32.132 µM 0.488309885077757 0.342008167642693 no 1160 0.312665180379878 1565 5889349 YGL099W LSG1
SGTC_3289 9119912 71.43 µM 0.486477357027098 0.342553325679013 no 1161 0.31331437777952 1508 17014829
SGTC_516 3992-2719 87.3 µM 0.485074253187751 0.342970956359417 no 1162 0.313811837419399 1407 5350887 YDR037W KRS1
SGTC_3248 9135562 49.47 µM 0.484457700674994 0.343154532546308 no 1163 0.3140305385126 1515 17650701
SGTC_3072 9116419 49.47 µM 0.483631584780237 0.343400563470813 no 1164 0.314323677515471 1453 17170162
SGTC_739 1486-1183 203 µM 0.483277274129748 0.343506103364059 no 1165 0.314449437026705 1570 4346692
SGTC_469 w7 172 µM 0.482372681708029 0.343775613159949 no 1166 0.314770611960734 1538 45115570 A P450 inhibitor.
SGTC_587 k089-0003 57 µM 0.479960291426378 0.344494736768465 no 1167 0.315627814340345 1509 9659696
SGTC_1977 st070720 65.3 µM 0.479012235776833 0.34477750234952 no 1168 0.315964962036563 1497 682188
SGTC_1574 spiramycin 23.7 µM 0.478637032875599 0.344889433738031 no 1169 0.316098434060406 1454 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2763 lisinopril 49.32 µM 0.476329480211362 0.345578126311387 no 1170 0.316919833036152 1491 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_14 0354-0009 295 µM 0.475325650684068 0.345877880520028 no 1171 0.317277439454164 1555 1713507
SGTC_2677 mitomycin C 100 µM 0.471636921867382 0.346980202963235 no 1172 0.31859298397907 1530 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1559 coumarin 343 70.1 µM 0.469128787713076 0.347730463005009 no 1173 0.319488791561815 1583 108770 A hepatotoxic, DNA x-linker.
SGTC_2214 7179297 48.276 µM 0.467142205827546 0.348325134395084 no 1174 0.320199069753193 1586 769744
SGTC_2823 7987624 58.44 µM 0.466715123456916 0.34845302771525 no 1175 0.320351854060717 1532 2239440
SGTC_1591 genipin 88.4 µM 0.465259634208721 0.348889015255273 no 1176 0.320872768943285 1576 442424 A DNA cross-linking agent.
SGTC_702 1488-0190 94 µM 0.464844098306049 0.349013524467969 no 1177 0.321021552686065 1630 949357
SGTC_2753 fluvastatin 17.09 µM 0.46429288539291 0.349178712382815 no 1178 0.321218960292982 1556 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_661 1304-0007 33.6 µM 0.462740783627572 0.349644000891057 no 1179 0.321775090654034 1510 3117130
SGTC_2426 5582046 32.21 µM 0.461971710867302 0.349874637010285 no 1180 0.322050803629186 1562 2251934
SGTC_2921 7974240 10.71 µM 0.460757502892588 0.350238876843774 no 1181 0.322486297202325 1593 2979074 YDR527W RBA50
SGTC_2780 5215298 71.43 µM 0.459641547581253 0.350573764237966 no 1182 0.322886765947085 1645 2834131
SGTC_3012 9080433 71.4286 µM 0.453687201353205 0.35236256378428 no 1183 0.325026990026483 1647 17688859
SGTC_1621 st003705 32.4 µM 0.453361469950226 0.352460514439003 no 1184 0.325144238152721 1646 24207032
SGTC_508 roscovitine 141 µM 0.451730730926758 0.352951040797143 no 1185 0.325731488357269 1611 160355 A CDKinase inhibitor.
SGTC_629 3448-6466 76.7 µM 0.450375665600616 0.353358830539475 no 1186 0.326219794160397 1555 573744
SGTC_547 1120-0019 610 nM 0.449349593496716 0.353667726007816 no 1187 0.326589743671201 1572 3676939
SGTC_1799 st045822 46.1415 µM 0.448714183667136 0.353859062280729 no 1188 0.326818925758011 1639 3674992
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.448603617096401 0.353892360148359 no 1189 0.326858812015934 1682 6728940
SGTC_2429 5902844 64.44 µM 0.448515115465974 0.353919013815885 no 1190 0.32689073989847 1663 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3114 9122766 49.47 µM 0.448454641896926 0.35393722680061 no 1191 0.326912557095597 1495 17176985
SGTC_1309 pyrazolanthrone 13.4 µM 0.447997320814056 0.354074970218904 no 1192 0.327077565090582 1650 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1797 st048695 56.8 µM 0.446547621211593 0.354511740524786 no 1193 0.327600860796892 1637 592262 YIL048W NEO1
SGTC_2262 9014885 67.46 µM 0.444972612866289 0.354986481172564 no 1194 0.328169773040376 1605 6457424
SGTC_3080 9117754 49.47 µM 0.444549724006257 0.355113987157227 no 1195 0.328322593629713 1672 9550191
SGTC_435 c-PAF 6.7 µM 0.442423818610775 0.355755218282256 no 1196 0.329091273136508 1558 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2495 cafestol 54.53 µM 0.440612081542334 0.356302010060244 no 1197 0.329746927442142 1596 16667697 An anti-infammatory.
SGTC_3164 9100705 49.47 µM 0.440518192389779 0.356330354365539 no 1198 0.329780919520393 1631 17174235
SGTC_3195 9113082 49.47 µM 0.439869072762266 0.356526339549467 no 1199 0.330015968346019 1657 17018038
SGTC_1456 k015-0012 13 µM 0.439377428879679 0.356674804153118 no 1200 0.330194039247849 1742 2989616
SGTC_2710 st078562 53.7235 µM 0.43911153104048 0.356755107942299 no 1201 0.330290362118046 1509 17250908
SGTC_2708 st078559 56 µM 0.438529663136889 0.356930859974292 no 1202 0.330501186009937 1535 17250902
SGTC_3095 9117207 49.47 µM 0.438233925837797 0.357020198474235 no 1203 0.330608358942518 1675 17015229
SGTC_1990 st072050 59.8 µM 0.436809199727024 0.357450700018546 no 1204 0.331124863292583 1535 17233948
SGTC_1192 1488-0095 21.4 µM 0.435428186674682 0.357868166247932 no 1205 0.331625827296432 1580 915875
SGTC_1000 4048-0884 8.67 µM 0.43480129846066 0.358057724338656 no 1206 0.331853331171523 1606 13040088
SGTC_2629 bisabolol 100 µM 0.434656979500505 0.358101368378943 no 1207 0.331905714721228 1656 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1381 2324-0066 62.1 µM 0.434218636492089 0.358233940706897 no 1208 0.332064840521159 1615 10885928
SGTC_2564 betulinic acid 100 µM 0.43118298138726 0.359152511615907 no 1209 0.333167663692077 1785 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1802 st050112 57.9 µM 0.431039309908203 0.35919600597395 no 1210 0.333219893969497 1578 4662563
SGTC_1432 4049-0298 68.4 µM 0.431025921697938 0.359200059144214 no 1211 0.333224761279372 1682 741646
SGTC_1783 st039459 87.517 µM 0.430743135819134 0.359285673938917 no 1212 0.333327575196532 1728 729761
SGTC_608 k048-0125 159 µM 0.430157030217306 0.359463142743857 no 1213 0.3335407084982 1644 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1516 st013856 110 µM 0.42826516481382 0.360036193470389 no 1214 0.334229038839059 1565 5281404 A mutagen and neurotoxin.
SGTC_1876 myriocin 605 nM 0.428066878263426 0.36009627320043 no 1215 0.334301215129386 1681 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_996 3970-0799 1.8 µM 0.427742553878635 0.360194549146892 no 1216 0.334419282387105 1663 6615648 YGL040C HEM2
SGTC_1348 1493-0373 93.8 µM 0.426401937895915 0.360600877143525 no 1217 0.334907494773835 1615 3010129
SGTC_3321 9137793 26.8275 µM 0.42493591470293 0.361045395098251 no 1218 0.335441696258004 1583 4904192
SGTC_2735 sertaconazole 140 nM 0.424863903994393 0.361067234555745 no 1219 0.335467944692205 1661 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1557 sumaresinolic acid 42.3 µM 0.424613880816264 0.361143065273912 no 1220 0.335559086218042 1527 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1765 st044815 90.4 µM 0.424256232616751 0.36125154758205 no 1221 0.335689477360867 1511 645695
SGTC_2331 7980721 200 µM 0.422648230093427 0.361739426710124 no 1222 0.336275966119608 1687 2981221
SGTC_2097 5376186 200 µM 0.422147066052086 0.361891529351031 no 1223 0.336458837862199 1675 742755
SGTC_2445 5742597 35.57 µM 0.421044681565777 0.362226178371516 no 1224 0.336861227437549 1558 1774255
SGTC_2081 5214970 32.255 µM 0.419840844343397 0.362591745542258 no 1225 0.337300862411523 1686 2063512
SGTC_2096 5468907 200 µM 0.419063181040401 0.362827963853595 no 1226 0.337584979122691 1717 759785
SGTC_433 pimozide 108 µM 0.4189506811035 0.362862140480088 no 1227 0.337626088272631 1504 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_362 0310-0100 9.03 µM 0.418367824083345 0.363039225501611 no 1228 0.337839103910034 1593 790235
SGTC_1037 k284-1091 78.7 µM 0.417261183844182 0.363375528162824 no 1229 0.338243688500232 1570 3334711
SGTC_2936 9038235 15.59 µM 0.416997071875522 0.363455806102489 no 1230 0.338340274736241 1582 4749415
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.415889066431566 0.363792654313075 no 1231 0.338745590241925 1600 2346 DNA damaging agent; causes G2/M arrest.
SGTC_407 eburnamonine 100 µM 0.4150813237994 0.364038285063577 no 1232 0.339041185442833 1554 3195
SGTC_2272 7805186 180 µM 0.414591736089204 0.364187193594036 no 1233 0.33922039940554 1633 2956062 YPR165W RHO1
SGTC_21 0849-0113 22.993 µM 0.413929578162244 0.364388622124043 no 1234 0.339462840699302 1572 1560156
SGTC_2843 9000894 45.46 µM 0.412913600214827 0.364697755562206 no 1235 0.33983495819332 1552 2242070
SGTC_1112 tnp00069 1.16933 µM 0.410935936743369 0.365299754985343 no 1236 0.340559755244299 1704 145826
SGTC_2397 5161689 200 µM 0.410429807667856 0.36545387375595 no 1237 0.340745342095657 1679 2259942
SGTC_3183 9108214 49.47 µM 0.408391039974699 0.366074908255506 no 1238 0.341493305242174 1599 4974831
SGTC_2560 caryophyllene 100 µM 0.407802890614507 0.366254131320493 no 1239 0.341709195630584 1609 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2832 7992762 51.95 µM 0.407135803815874 0.36645744381056 no 1240 0.341954124046325 1448 2985177
SGTC_1393 3470-5649 58.2 µM 0.406560751130529 0.366632736536862 no 1241 0.342165314501634 1584 4108395
SGTC_333 3486-0131 40.1 µM 0.40630787001617 0.366709830839713 no 1242 0.342258201763029 1732 6744690
SGTC_3040 9091894 49.47 µM 0.400834737427419 0.368379703772359 no 1243 0.344270900871281 1682 25236966
SGTC_2685 mycophenolic acid 18.85 µM 0.399907295567922 0.368662917205649 no 1244 0.344612399296834 1679 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_832 4083-0019 164 µM 0.399841004043113 0.368683163419262 no 1245 0.344636813714772 1767 1990758
SGTC_1867 st057372 64 µM 0.398591216526348 0.369064931423782 no 1246 0.345097217311956 1627 688837
SGTC_2303 7774051 200 µM 0.397113190872035 0.369516585221966 no 1247 0.345641996558827 1704 2953184
SGTC_1650 st011916 45.8 µM 0.396852871629032 0.369596152023881 no 1248 0.345737979687822 1724 242528
SGTC_1169 aniline yellow 25.8 µM 0.396816992551955 0.369607118932814 no 1249 0.345751209553158 1696 6051 A DNA damaging agent.
SGTC_952 1185-0122 232 µM 0.396614574169574 0.369668992744659 no 1250 0.345825851789239 1588 678600
SGTC_2678 equilin 100 µM 0.395874814098222 0.369895146036887 no 1251 0.346098690938442 1724 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_593 1203-0218 61.7 µM 0.392014325888335 0.371076070939351 no 1252 0.347523814378831 1738 3666956
SGTC_1220 1838-0075 193 µM 0.391561550385328 0.371214654974625 no 1253 0.347691101059207 1671 5529645
SGTC_1372 2752-0194 270 µM 0.388160395504705 0.372256202025158 no 1254 0.348948669834611 1586 823334
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.386597921701663 0.372734997576339 no 1255 0.349526948394149 1757 94937 An inhibitor of serotonin biosynthesis.
SGTC_2842 9000675 19.48 µM 0.385268764245079 0.373142451866962 no 1256 0.35001915062026 1545 2989072
SGTC_3202 9113761 49.47 µM 0.38489010183402 0.373258557128974 no 1257 0.350159419822442 1791 4798415
SGTC_3100 9120536 49.47 µM 0.384473556814605 0.37338629122919 no 1258 0.350313745622318 1729 16421196
SGTC_2967 9089538 49.85 µM 0.384351108103714 0.37342384294084 no 1259 0.350359116357663 1826 728216
SGTC_992 3909-8734 162 µM 0.383964523054786 0.373542406018243 no 1260 0.350502371140151 1627 4288319
SGTC_864 0469-0573 172 µM 0.383898478105648 0.373562662764831 no 1261 0.350526847195962 1625 689425
SGTC_1795 st049545 62.3 µM 0.383513805367511 0.373680653265353 no 1262 0.350669418064896 1768 5291882
SGTC_1751 st044839 27.194 µM 0.382215309643174 0.374079027674843 no 1263 0.351150833462779 1681 5291326
SGTC_2889 9059656 51.95 µM 0.381588975695443 0.374271233080877 no 1264 0.351383131344551 1704 3949838
SGTC_2665 lovastatin 100 µM 0.381549851602233 0.374283240273107 no 1265 0.351397643728203 1648 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_249 wiskostatin 11.211 µM 0.380316790882596 0.374661729288882 no 1266 0.35185513648956 1743 2775510 A n-wasp and actin depolymerizer.
SGTC_442 cape 100 µM 0.3797091733746 0.374848282435706 no 1267 0.3520806549693 1768 5281787
SGTC_2314 7727897 200 µM 0.378748235876927 0.375143373064702 no 1268 0.352437415079846 1606 900724
SGTC_110 0850-0284 111.64 µM 0.378081578886759 0.375348137170607 no 1269 0.352684996175088 1609 3906265
SGTC_2393 9031399 185.94 µM 0.371979102652389 0.37722414218718 no 1270 0.354954204202419 1744 1526623 YDL150W RPC53
SGTC_2358 9037157 4 µM 0.371207000918454 0.377461707073509 no 1271 0.355241679538315 1698 2388925
SGTC_2408 sulbentine 18.36 µM 0.370709070109491 0.377614938009064 no 1272 0.355427116993314 1732 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3308 9128332 17.569 µM 0.366298667099329 0.378973013554718 no 1273 0.357071112044808 1796 17332805 YDL196W YDL196W
SGTC_2654 protoveratrine a 100 µM 0.364240451207671 0.379607303533208 no 1274 0.357839231454882 1697 5702278 A heart drug and vasodilator.
SGTC_1785 bathophenanthroline 24 µM 0.364106511972855 0.379648591461545 no 1275 0.357889237131402 1624 72812 An iron chelator.
SGTC_2143 5623677 140.463 µM 0.362829870999283 0.380042195901264 no 1276 0.358365988212878 1710 5375313
SGTC_1326 1431-2094 10.8 µM 0.359892631612265 0.380948254980121 no 1277 0.359463713736675 1644 616278
SGTC_941 3237-0776 460 µM 0.358751939425157 0.381300304098951 no 1278 0.359890334597886 1791 760008
SGTC_855 0428-0020 25 µM 0.358021053352848 0.381525927392399 no 1279 0.3601637790778 1686 6812414
SGTC_2182 6325192 200 µM 0.357329072785183 0.381739577730277 no 1280 0.360422733895602 1708 736248
SGTC_1560 lithocholic acid 53.1 µM 0.357225434351029 0.381771579400957 no 1281 0.360461523263876 1794 9903 A bile acid which acts as a detergent.
SGTC_1005 4092-0690 4.4 µM 0.356003326175225 0.382149005149453 no 1282 0.360919037116747 1657 1529343
SGTC_1662 st014054 52 µM 0.355844909878826 0.382197937332569 no 1283 0.36097835713544 1697 2838777
SGTC_2003 4023581 200 µM 0.355779059231032 0.382218278066046 no 1284 0.361003016325379 1691 16641307
SGTC_2239 6685329 187.64 µM 0.355613588396241 0.382269392105562 no 1285 0.361064982984412 1684 805680
SGTC_2975 9084847 53.72 µM 0.35102967038248 0.383686179806517 no 1286 0.362783044634344 1689 27211724
SGTC_1344 1488-0097 29.1 µM 0.350752812521133 0.383771800477423 no 1287 0.362886900431472 1729 747966
SGTC_2286 7945697 125 µM 0.350039544793585 0.383992410779134 no 1288 0.36315451012501 1621 1245733
SGTC_2490 carminic acid 95.39 µM 0.349981225956458 0.384010450180542 no 1289 0.363176393626138 1709 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_509 pifithrin 175 µM 0.34784246363428 0.384672193466549 no 1290 0.363979248644985 1753 4817 A p53 inhibitor.
SGTC_1935 st074532 41.6 µM 0.345332229440284 0.385449300627843 no 1291 0.3649223098391 1870 2829742
SGTC_2764 methyldopa 94.69 µM 0.345332117829471 0.385449335190075 no 1292 0.364922351788002 1817 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1277 0873-0036 22 µM 0.344443379642853 0.385724577272869 no 1293 0.365256435082658 1805 5965735
SGTC_2024 5144227 134 µM 0.344068354248303 0.385840739854975 no 1294 0.365397440618816 1777 3475211
SGTC_1107 amlodipine 47 µM 0.343551144850087 0.386000960144459 no 1295 0.365591935666916 1675 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2970 9090938 41.86 µM 0.343378263763455 0.386054519305126 no 1296 0.365656954792203 1870 17217104
SGTC_929 2805-0021 398 µM 0.341513924533782 0.386632235860999 no 1297 0.366358362021153 1730 3098024
SGTC_398 bronopol 33.3 µM 0.339972004023923 0.387110232111182 no 1298 0.366938805539516 1753 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1088 bifonazole 369 nM 0.338406898147936 0.387595590966954 no 1299 0.367528288248382 1706 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.337087031296706 0.388005034749909 no 1300 0.368025646719824 1721 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2204 7233102 200 µM 0.332620968032282 0.389391400049834 no 1301 0.369710206796243 1780 2172480
SGTC_3219 9131112 49.47 µM 0.328668357387372 0.390619554299358 no 1302 0.37120318694741 1751 17612988 YMR079W SEC14
SGTC_177 1327-0068 8.361 µM 0.326294031656711 0.391357830081974 no 1303 0.372100951698359 1710 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2861 9024595 19.48 µM 0.324772716348981 0.391831075744551 no 1304 0.372676547663682 1788 16482810
SGTC_1701 st028638 40.4 µM 0.324136434888509 0.392029055569376 no 1305 0.37291737183298 1838 3490878
SGTC_1897 st060201 15 µM 0.324048081751296 0.392056548977569 no 1306 0.372950816263719 1699 611878
SGTC_2775 cyproheptadine 69.59 µM 0.320856400938579 0.393050084977111 no 1307 0.374159607692267 1860 2913 A selective serotonin reuptake inhibitor.
SGTC_3049 9092223 49.47 µM 0.319503597631409 0.393471408859384 no 1308 0.374672331864522 1776 8623917
SGTC_2829 7992743 58.44 µM 0.317647347517702 0.394049731728789 no 1309 0.375376227313912 1937 16462845
SGTC_2745 rifampicin 24.3 µM 0.317064672812682 0.394231314843508 no 1310 0.375597264974905 1887 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3051 9093778 49.47 µM 0.316924064193737 0.394275137164998 no 1311 0.375650610976587 1779 17217378
SGTC_1106 tegaserod maleate 11.7 µM 0.316911254577679 0.394279129498263 no 1312 0.375655470980334 1781 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1194 1488-0194 225 µM 0.31669045597975 0.394347946857125 no 1313 0.375739245679147 1756 1391452
SGTC_677 0929-0063 136 µM 0.316033333615286 0.394552774843752 no 1314 0.37598860359434 1732 1539583
SGTC_3155 9099265 49.47 µM 0.315288157420269 0.394785084880557 no 1315 0.376271437914939 1794 25236499
SGTC_481 bay k-8644 50 µM 0.315134859362954 0.394832880472249 no 1316 0.376329630994033 1711 2303 A calcium channel antagonist.
SGTC_2132 5317594 122.667 µM 0.314157247389068 0.395137719599 no 1317 0.376700805826465 1797 794577
SGTC_1479 0549-0158 134 µM 0.312409845118734 0.395682754660235 no 1318 0.377364534610998 1740 5440202
SGTC_839 0122-0028 230 µM 0.311879576340919 0.395848192057337 no 1319 0.377566022303869 1786 759448
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.311701980605846 0.395903603958651 no 1320 0.377633511298148 1774 65057 A dermal irritant. YDR527W RBA50
SGTC_3041 9091929 49.47 µM 0.309923972316315 0.396458478671514 no 1321 0.37830938624764 1812 25236887
SGTC_2689 tacrolimus 100 µM 0.309766953532213 0.396507490650755 no 1322 0.378369091786993 1759 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2156 5649887 115 µM 0.30887624517528 0.396785548057531 no 1323 0.378707833722001 1872 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2292 7671323 168.05 µM 0.307655303888953 0.397166781385131 no 1324 0.379172316696003 1756 937504
SGTC_116 0155-0182 31.788 µM 0.306155792628353 0.397635131347854 no 1325 0.379743014815175 1744 771486
SGTC_11 0438-0307 1.3 µM 0.306150206929624 0.397636876233814 no 1326 0.379745141163634 1888 4011476
SGTC_1748 st037455 53.6035 µM 0.305263503691214 0.397913894567222 no 1327 0.380082734982999 1799 580690
SGTC_1787 fluconazole 80 µM 0.303420114441727 0.398489959410976 no 1328 0.380784859322122 1780 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2373 9071805 200 µM 0.301309063836356 0.399149940990862 no 1329 0.381589414978597 1942 10149009
SGTC_616 4092-0450 108 µM 0.301000524849546 0.399246424292727 no 1330 0.381707047150525 1808 787165
SGTC_2033 5192550 145 µM 0.300676162181415 0.399347862458244 no 1331 0.381830723966967 1749 182073
SGTC_1453 4237-0541 195 µM 0.300627682538409 0.39936302411505 no 1332 0.381849209892406 1902 739892
SGTC_1086 cerivastatin 2.18 µM 0.300093159760999 0.399530202295855 no 1333 0.382053048309853 1846 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2945 9067681 61.76 µM 0.299773174549218 0.399630290189114 no 1334 0.382175089216885 1815 16456930
SGTC_1362 1611-0397 101 µM 0.299104530311755 0.399839456117346 no 1335 0.382430144871001 1748 27816
SGTC_1230 0170-0365 3.77 µM 0.29515960003573 0.401074096119075 no 1336 0.383935981169089 1896 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1837 st055472 66.5 µM 0.293743428013805 0.401517555538695 no 1337 0.384476983341674 1839 676091
SGTC_636 0kpi-0074 126 µM 0.292822998186959 0.401805846548566 no 1338 0.384828724189618 1794 616434
SGTC_1222 0366-0074 1.18 µM 0.292488188251846 0.401910726790228 no 1339 0.384956694825106 1909 286520
SGTC_1025 k007-0731 70 µM 0.291829934577597 0.402116947368146 no 1340 0.385208328251651 1752 6256118
SGTC_2605 digitonin 300 nM 0.2916426102406 0.402175638135612 no 1341 0.385279946361731 1952 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2587 piperic acid 92.2 µM 0.28995522168321 0.402704414725892 no 1342 0.385925247270951 1760 5370536
SGTC_1047 2043-3044 82 µM 0.288992032602604 0.403006328960552 no 1343 0.386293737309519 1731 669592
SGTC_3262 9137218 49.47 µM 0.287941304863927 0.403335748381704 no 1344 0.386695834249054 1826 17650664
SGTC_289 k017-0060 526 µM 0.287884011536336 0.403353712701788 no 1345 0.386717763004011 1798 5512909
SGTC_2016 5121758 140 µM 0.28584488028965 0.403993214730755 no 1346 0.387498466037955 1808 2795203
SGTC_233 rapamycin 362 pM 0.285543861340298 0.404087640554838 no 1347 0.387613752965604 1900 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1681 tripelennamine 100 µM 0.280238341472255 0.405752827305054 no 1348 0.389647326207357 1796 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1414 3917-0015 5.4 µM 0.280017506354198 0.405822175669145 no 1349 0.389732036913039 1882 6618702
SGTC_1278 0874-0585 172 µM 0.279874138527409 0.405867198733337 no 1350 0.389787034547656 1863 766306
SGTC_1031 k035-0009 16 µM 0.279745546154084 0.405907582790724 no 1351 0.389836366016805 1953 5180959
SGTC_2772 vinpocetine 57.06 µM 0.27769188242813 0.406552665262649 no 1352 0.390624446250655 1887 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1433 4060-0023 7.6 µM 0.276826825025477 0.406824467074103 no 1353 0.390956541203169 1875 3840627
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.276172177841701 0.407030187651476 no 1354 0.391207912697732 1909 688662
SGTC_1916 st067606 49.2 µM 0.276140234159065 0.407040226498355 no 1355 0.391220179600165 1907 19590279
SGTC_3330 9141424 71.43 µM 0.275750290653272 0.407162777814439 no 1356 0.391369933074662 1913 27261020
SGTC_204 PMA1.184 62.41 µM 0.273517285192723 0.407864740735237 no 1357 0.3922278035382 1840 2252213 YGL008C PMA1
SGTC_275 trichlorophene 5.69 µM 0.273319861327815 0.407926816756153 no 1358 0.392303674621155 1840 62616
SGTC_872 0588-0139 234 µM 0.272758306429791 0.408103399194852 no 1359 0.392519505649134 1798 2047100
SGTC_1597 7-benzyloxygramine 47.5 µM 0.272384129060153 0.408221070633466 no 1360 0.392663337348607 1789 260807
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.271718255670792 0.408430495209655 no 1361 0.392919331620921 1838 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_522 1273-0010 11.6 µM 0.271484812743267 0.408503921797994 no 1362 0.393009089462374 1850 5705015
SGTC_1313 1220-0047 237 µM 0.270812525249974 0.408715399458913 no 1363 0.393267612992499 1874 3528706
SGTC_1957 st077035 62.4 µM 0.27006226325823 0.408951436497167 no 1364 0.393556176652679 1885 705593
SGTC_2779 methotrexate 400 µM 0.269365364687932 0.409170714659303 no 1365 0.393824268210072 1930 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2905 7799065 20.05 µM 0.26566342958204 0.410335998328212 no 1366 0.395249215245393 1946 1296806
SGTC_2817 7995342 71.43 µM 0.265173670804923 0.410490222629019 no 1367 0.39543783836204 1762 18879975
SGTC_2332 7982454 138.89 µM 0.264874461850386 0.410584449890905 no 1368 0.395553086181243 1873 2981748
SGTC_898 1000-0849 28.3 µM 0.25978635424525 0.412187589006869 no 1369 0.397514288700723 1970 6751807
SGTC_2596 sinensetin 100 µM 0.259002972540534 0.412434544489745 no 1370 0.39781647348977 1799 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2051 5263410 176 µM 0.258986111671716 0.412439860139614 no 1371 0.397822978143395 1959 227584
SGTC_3120 9124077 49.47 µM 0.258589816412876 0.412564802976787 no 1372 0.397975870694158 1971 18774327 YGL155W CDC43
SGTC_1810 st050138 53 µM 0.258164919505216 0.41269877310223 no 1373 0.398139815299248 1966 3444541
SGTC_2374 9071832 200 µM 0.255622465428727 0.41350062162647 no 1374 0.399121184849213 1945 17381698
SGTC_2473 5854593 8.94 µM 0.253525567860169 0.414162220616475 no 1375 0.399931053045292 1841 2872951
SGTC_1421 4029-0249 71.4 µM 0.252846570480803 0.414376505609238 no 1376 0.400193389307399 1994 2894095
SGTC_2940 9060638 45.86 µM 0.251587727067971 0.414773851776506 no 1377 0.400679872966305 1858 4027022
SGTC_2515 chrysin 20.77 µM 0.250039253746289 0.415262737421986 no 1378 0.4012784962194 1944 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_870 0573-2213 57.6 µM 0.249618460519338 0.415395613414703 no 1379 0.401441210502219 1906 3916321
SGTC_699 0375-0592 111 µM 0.248795043520737 0.415655655919597 no 1380 0.40175966264042 2038 762578
SGTC_733 4069-0007 56.1 µM 0.247303510799411 0.416126789374653 no 1381 0.402336670968665 1905 5717425 YNL287W SEC21
SGTC_3058 9093861 49.47 µM 0.246980549475645 0.416228819721161 no 1382 0.402461638561526 1914 17217477
SGTC_1866 st057638 64 µM 0.245976832058925 0.416545951393771 no 1383 0.402850083471565 1851 688802
SGTC_2244 6635614 200 µM 0.244883990791993 0.416891304154398 no 1384 0.403273128924607 1863 836499
SGTC_805 3852-0218 479 µM 0.244818249194597 0.416912081444801 no 1385 0.403298581509307 1809 6615355
SGTC_836 0330-0104 1.35 µM 0.242399936262571 0.417676537506164 no 1386 0.404235141879147 1899 46494820
SGTC_2952 9073731 13.78 µM 0.24192557171653 0.417826526103392 no 1387 0.404418917611597 1830 16457353
SGTC_189 3970-0742 2.116 µM 0.241615688686369 0.417924513999287 no 1388 0.404538982201651 1990 2891807
SGTC_2493 resveratrol 26.09 µM 0.241057630561521 0.418100990014749 no 1389 0.404755225225641 1851 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_321 4534-3890 65.3 µM 0.238744875707587 0.418832533247802 no 1390 0.405651708486799 1990 699746
SGTC_2974 9094440 9.66 µM 0.2365679711829 0.419521362474688 no 1391 0.40649598511261 1941 25236134
SGTC_3331 9141060 1.957 µM 0.23283566492863 0.420702934218805 no 1392 0.407944508650549 1843 4906567 YPR165W RHO1
SGTC_1475 4092-1048 11.7 µM 0.23139913792351 0.421157900337239 no 1393 0.408502367414371 1908 2881759
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.231310778412137 0.421185888346471 no 1394 0.408536686881801 1977 165506
SGTC_2715 st079500 56.4 µM 0.22919000201999 0.421857766665251 no 1395 0.409360621509597 1862 28246688
SGTC_1462 k081-0014 26.5 µM 0.22895301314599 0.421932860736945 no 1396 0.409452718087078 1923 3270634
SGTC_961 1252-1571 372 µM 0.228776996576218 0.421988636504321 no 1397 0.409521123366582 2009 6813498
SGTC_2158 5657123 3.6195 µM 0.226321430978964 0.422766913757318 no 1398 0.410475715635486 2012 2858827
SGTC_1561 5-methoxyflavone 52.9 µM 0.225963589745971 0.422880354704335 no 1399 0.410614869554149 2008 94525
SGTC_553 k007-0256 45.7 µM 0.225636501955473 0.422984051951324 no 1400 0.41074207420831 1905 6287000
SGTC_1623 st003709 20.3 µM 0.224088070450015 0.42347502636173 no 1401 0.41134438743112 1843 16192618
SGTC_2475 5812728 15.03 µM 0.223607428795644 0.423627451724184 no 1402 0.411531391344031 1985 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_705 1124-0212 310 µM 0.223503236153001 0.423660495731108 no 1403 0.411571932371765 2028 9554485
SGTC_2911 7942208 15.64 µM 0.223139784193511 0.423775766315255 no 1404 0.411713357767637 1883 1243384
SGTC_3112 9123419 49.47 µM 0.222864765261647 0.423862994263601 no 1405 0.411820379978916 2038 17015854
SGTC_1703 st026983 48.3 µM 0.221693811228091 0.424234428284642 no 1406 0.412276124084629 2036 1104023
SGTC_1190 1486-1332 13 µM 0.220991637970068 0.424457194383066 no 1407 0.412549471980095 1976 4150046
SGTC_18 0111-0177 500 nM 0.220913781157856 0.424481896125306 no 1408 0.412579783347844 1914 721752
SGTC_2541 muurolladie-3-one 83.07 µM 0.220457896615134 0.424626541216736 no 1409 0.412757279675686 1944 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2216 7189485 200 µM 0.219986663067245 0.424776066978051 no 1410 0.41294077081115 2001 731273
SGTC_1653 st012112 65 µM 0.218643540645931 0.425202308612839 no 1411 0.413463866383335 1990 720429
SGTC_339 3091-4833 71.4 µM 0.216045392594924 0.426027082021032 no 1412 0.414476182401858 1959 3240077
SGTC_2838 9002687 71.43 µM 0.214637917545459 0.426474015671726 no 1413 0.415024814456607 1843 6457060
SGTC_1979 st071809 45.3 µM 0.213955516608098 0.426690741243769 no 1414 0.415290873240544 2001 4976333
SGTC_115 0527-0192 112.043 µM 0.213839255261778 0.426727667209981 no 1415 0.415336205824333 1914 4233931
SGTC_1386 3228-0095 33.8 µM 0.212459317604639 0.42716600054265 no 1416 0.415874356551556 2009 870181
SGTC_57 miconazole 162.5 nM 0.210440851415007 0.427807322528019 no 1417 0.41666180580253 1875 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2850 9015429 58.44 µM 0.209235067675044 0.428190524174418 no 1418 0.417132369092017 1907 6457570
SGTC_2319 6033012 152.6 µM 0.208952242135562 0.428280416788421 no 1419 0.41724276042494 1892 847246
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.206124236795972 0.429179467356087 no 1420 0.418346933518977 1932 115019
SGTC_1649 st011737 51.3 µM 0.205570106874548 0.429355673887239 no 1421 0.418563365018929 1929 1761035
SGTC_968 1309-0633 340 µM 0.205508393503824 0.42937529885541 no 1422 0.41858747049139 2063 3761976
SGTC_2991 9074669 71.4286 µM 0.204377947795284 0.429734813555181 no 1423 0.419029080796467 2007 17333109
SGTC_1201 1889-3372 45.9 µM 0.203902760602371 0.429885954353179 no 1424 0.419214743876303 1936 5392199
SGTC_2159 5658611 73.75 µM 0.203900732245588 0.429886599526156 no 1425 0.41921553642566 2054 793844
SGTC_3259 9138485 49.47 µM 0.200931272509091 0.43083131528692 no 1426 0.420376157214543 2041 17646153
SGTC_2479 5617353 43.85 µM 0.200477409059471 0.430975744232176 no 1427 0.420553612155582 2010 2731746
SGTC_2375 9072683 200 µM 0.200152701938835 0.431079078568735 no 1428 0.420680578495411 2089 16798029
SGTC_2298 7976326 193.81 µM 0.199624303570796 0.431247245403667 no 1429 0.420887209420854 2020 2235818
SGTC_595 3909-8003 73.7 µM 0.197502140712236 0.431922765266897 no 1430 0.421717303193792 2001 699517
SGTC_729 4092-0585 94.1 µM 0.197030073303217 0.432073059343721 no 1431 0.421902001975383 1891 2169061
SGTC_846 0335-0850 148 µM 0.196738306553685 0.432165955262199 no 1432 0.422016165797315 2049 6819598
SGTC_620 0109-0052 432 µM 0.196329673856662 0.432296066554666 no 1433 0.422176068473564 2061 493037
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.194819391921266 0.43277701369952 no 1434 0.422767170301938 1958 4213774
SGTC_1467 k284-1082 293 µM 0.19434928545121 0.432926738799564 no 1435 0.422951198523994 2093 3334705
SGTC_1330 1469-0054 61.8 µM 0.194116403977163 0.433000913229319 no 1436 0.423042368706253 2086 7102664
SGTC_284 0988-0104 32.6 µM 0.192169827881975 0.433621003841916 no 1437 0.423804589632265 2054 4666532
SGTC_2558 carylophyllene oxide 100 µM 0.189379835565616 0.434510053107287 no 1438 0.424897563694257 2112 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2354 9060492 162 µM 0.188797961273737 0.434695513050161 no 1439 0.42512558488774 2057 6471895
SGTC_959 1222-0044 107 µM 0.186995033578193 0.435270248630405 no 1440 0.425832263447962 2121 6083612
SGTC_1333 1482-0047 286 µM 0.18573646859957 0.43567153391614 no 1441 0.426325714047467 2109 3811116
SGTC_1471 k673-0312 37 µM 0.18536253824647 0.435790771968613 no 1442 0.426472344678489 2081 24099884
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.185008713082071 0.43590360429954 no 1443 0.426611100749824 1981 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2614 arthonioic acid 13.39 µM 0.184856384956791 0.435952182263434 no 1444 0.426670840543263 2040 6710684
SGTC_2802 7925815 54.55 µM 0.183840956905921 0.436276030421248 no 1445 0.427069112363116 1956 1262923
SGTC_640 3381-0960 37.1 µM 0.183400395338793 0.436416551021396 no 1446 0.427241932846027 2060 1745025
SGTC_2069 5228469 200 µM 0.179641229800044 0.437615891225762 no 1447 0.428717117242124 1980 2835210
SGTC_2719 novobiocin 32.65 µM 0.179530611170082 0.437651192203615 no 1448 0.428760541769756 2074 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_118 0083-0097 135.343 µM 0.1790578096657 0.437802079751367 no 1449 0.428946154776768 1958 5207356
SGTC_2390 9097792 176.6 µM 0.177398246776361 0.438331775939637 no 1450 0.429597792173774 1910 4497149
SGTC_650 1328-0195 38 µM 0.176127002332994 0.438737604160175 no 1451 0.430097083859345 2099 2780821
SGTC_95 0471-0001 561.058 µM 0.174209156119375 0.439349973332638 no 1452 0.430850545012765 1892 4015405
SGTC_1945 st075991 56.6 µM 0.174136666003377 0.439373122316156 no 1453 0.430879029042972 1926 1084980
SGTC_3268 9137683 49.47 µM 0.172826673610673 0.439791490753882 no 1454 0.431393835007441 1968 1953228
SGTC_2248 tofa 1.1 µM 0.171332302248184 0.440268825846874 no 1455 0.431981241226119 1975 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1806 st050005 60.3 µM 0.169448075594293 0.440870812968985 no 1456 0.432722105666744 1949 5194765
SGTC_770 0389-1121 67.2 µM 0.169401275932533 0.440885766627407 no 1457 0.432740509980527 2102 6753108
SGTC_517 1365-0151 113 µM 0.168907545547759 0.441043530922867 no 1458 0.432934681994852 2008 768657
SGTC_258 haloperidol 50.781 µM 0.167931637689103 0.441355395452368 no 1459 0.433318530141776 1937 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_787 4152-0075 138 µM 0.167906170885115 0.441363534201044 no 1460 0.433328547695106 1976 9566539
SGTC_2310 7668677 200 µM 0.167659872361489 0.441442248212858 no 1461 0.433425433227579 2053 2197143
SGTC_1936 st074407 74.3 µM 0.167230812628724 0.441579376006013 no 1462 0.433594220408089 1932 809813
SGTC_710 3448-4187 58 µM 0.164900981338309 0.442324113565947 no 1463 0.434510959989496 2023 3946412
SGTC_2528 xanthyletin 44.79 µM 0.164596019338532 0.442421610730064 no 1464 0.43463098229525 1997 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1408 3909-7976 48.8 µM 0.16412906633725 0.442570903605308 no 1465 0.434814770227015 2030 24152374
SGTC_1873 rapamycin 2 nM 0.163123704620373 0.442892362626863 no 1466 0.435210518091183 1996 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2523 spermine 47.74 µM 0.162729803715025 0.443018320592931 no 1467 0.435365589895807 2113 1103 A DNA binding polyamine.
SGTC_902 1120-0002 2.07 µM 0.160564221791647 0.443710912754149 no 1468 0.436218318038339 2092 3280475
SGTC_3280 9140961 49.47 µM 0.160442813170665 0.443749746531511 no 1469 0.436266133194597 1968 4901226
SGTC_2920 7982904 15.77 µM 0.157648784432702 0.444643593436993 no 1470 0.437366779891214 2019 6456808
SGTC_2785 7756463 72.73 µM 0.157505967216552 0.444689290164241 no 1471 0.437423052717263 2036 2201551
SGTC_1614 st002383 48.6 µM 0.156538383548709 0.444998903871824 no 1472 0.437804333225575 2170 1947235
SGTC_3007 9078383 71.4286 µM 0.156177082494701 0.445114523944613 no 1473 0.43794672028878 2014 6496995
SGTC_538 2922-0838 53.3 µM 0.156143788112338 0.445125178726306 no 1474 0.437959841854448 2145 777039
SGTC_3094 9117742 49.47 µM 0.155549327381911 0.445315423169359 no 1475 0.438194134753226 2151 17149698
SGTC_1050 3232-1156 69.3 µM 0.154385873018009 0.445687798261063 no 1476 0.438652745907258 1992 700529
SGTC_1620 st003704 16.5 µM 0.153930760390464 0.445833474620805 no 1477 0.438832164931274 2125 2834414
SGTC_673 1082-0474 110 µM 0.153800470819296 0.445875180173332 no 1478 0.438883531297059 2046 3098046
SGTC_1061 3448-9325 110 µM 0.153634659348658 0.445928257113902 no 1479 0.438948903578972 2163 723482
SGTC_47 0149-0135 24.25 µM 0.153301893144828 0.446034779880886 no 1480 0.439080103904699 2082 5239155
SGTC_276 colchicine 750 µM 0.152551563352881 0.446274984436318 no 1481 0.439375962311435 2050 2833 A microtubule depolymerizer.
SGTC_2011 4012611 177 µM 0.152241635278705 0.446374208080694 no 1482 0.439498178235888 2024 2049887
SGTC_2134 5324836 1.464 µM 0.151362109418908 0.446655807036126 no 1483 0.43984503867201 2061 699272
SGTC_3217 9129673 49.47 µM 0.151088524534764 0.446743406561617 no 1484 0.439952942338455 2062 17248312
SGTC_52 0329-0193 875 nM 0.150619681368363 0.446893532149036 no 1485 0.440137867514634 2118 3739292
SGTC_1630 st005209 31.3 µM 0.14985581948994 0.447138140281208 no 1486 0.440439184475736 2181 3367314
SGTC_1429 4049-0205 9.46 µM 0.149837471969733 0.447144015874651 no 1487 0.440446422359638 2137 22774478
SGTC_994 3910-0338 138 µM 0.148898516375472 0.447444721633103 no 1488 0.440816855962702 2094 3479481
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.148716421024828 0.447503042186296 no 1489 0.44088870161419 2162 1241132 A phosphatase inhibitor.
SGTC_3201 9113999 49.47 µM 0.148245986898314 0.44765371563595 no 1490 0.441074320220646 2081 16649224
SGTC_3038 9091290 49.47 µM 0.147711149867454 0.447825025606914 no 1491 0.441285365923676 2120 25236843
SGTC_3305 9127027 53.8275 µM 0.144609703082289 0.448818619549323 no 1492 0.442509517908444 2054 41905295
SGTC_1724 st037281 8.293 µM 0.144253324283233 0.448932811406585 no 1493 0.442650217271619 2053 574124 YDL195W SEC31
SGTC_1336 1486-0901 104 µM 0.143771409615811 0.449087234532131 no 1494 0.442840490053422 2069 5006114
SGTC_838 0109-0203 71.4 µM 0.142176140507292 0.449598472128386 no 1495 0.443470438719601 2133 759422
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.139729292781021 0.450382778337484 no 1496 0.444436940577451 2166 551469
SGTC_731 3966-0296 387 µM 0.138390412378693 0.450812021817228 no 1497 0.444965936960924 2123 660956
SGTC_1898 st060199 18.6 µM 0.136007128266676 0.451576241935203 no 1498 0.445907822894666 2097 688866
SGTC_2827 7993847 71.43 µM 0.135684970867065 0.45167955825173 no 1499 0.44603516467211 2071 2985692
SGTC_1203 3992-3522 103 µM 0.133048017207365 0.452525355290044 no 1500 0.447077702895394 2205 5322312
SGTC_2259 7964009 200 µM 0.132770752053313 0.45261430005868 no 1501 0.44718734300757 2129 313134
SGTC_545 4218-0007 221 µM 0.132485546051071 0.452705794678129 no 1502 0.447300127413539 2094 2840508
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.131479302258571 0.453028619597244 no 1503 0.447698079417507 2042 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2416 tofa 880 nM 0.131158537005175 0.453131534611107 no 1504 0.447824947609733 1899 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3087 9117406 49.47 µM 0.13102901585895 0.453173091346862 no 1505 0.447876176971318 2050 42546093
SGTC_3185 9108267 49.47 µM 0.12914082947432 0.453778972140764 no 1506 0.448623107619006 2041 4910486
SGTC_919 tnp00227 403.569 nM 0.128244230007025 0.454066710522563 no 1507 0.448977849272473 2082 1269246 A methoxyflavone. YNL221C POP1
SGTC_2402 5553605 200 µM 0.124032448921899 0.455418683372445 no 1508 0.450644791452156 2138 6758546
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.123825856615147 0.455485012482731 no 1509 0.450726579373035 2085 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2061 5245884 80.95 µM 0.123793627161696 0.455495360274143 no 1510 0.450739338894552 2135 573863
SGTC_918 glabranin 770.725 nM 0.123148259024834 0.455702572580919 no 1511 0.450994848453489 2109 124049 Also referred to as licorice root.
SGTC_759 3486-0358 89.3 µM 0.121087291497765 0.456364380481804 no 1512 0.451810947511151 2224 875103
SGTC_1552 6-methylflavone 10.6 µM 0.120200118462226 0.456649302568203 no 1513 0.452162311968754 2203 689013
SGTC_1044 1222-0021 1.78 µM 0.119948609398108 0.456730080598664 no 1514 0.452261928842652 2115 4306703
SGTC_537 1334-0398 209 µM 0.118335050073329 0.457248355382686 no 1515 0.452901093276111 2226 5846986
SGTC_1441 4106-0040 13 µM 0.117525008080445 0.457508568106041 no 1516 0.453222013889859 2202 2904180
SGTC_396 dithiazanine 1.25 µM 0.116063746417579 0.457978020478203 no 1517 0.453801010376713 2042 10578 An antihelmenthic.
SGTC_2549 cedrol 20.94 µM 0.114638176306813 0.458436062904563 no 1518 0.454365959427524 2221 6708665 A sedative which affects the nervous system.
SGTC_162 k030-0015 37.8 µM 0.114436784562238 0.458500775489226 no 1519 0.454445777826155 2175 1809920 YMR134W ERG29
SGTC_216 k038-0035 28.382 µM 0.114267355159498 0.458555218565688 no 1520 0.454512929886466 2194 4444231 YPR107C YTH1
SGTC_2119 5528445 120.635 µM 0.113278212434966 0.458873077189292 no 1521 0.454904995001809 2165 791935
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.112879078199183 0.459001345468918 no 1522 0.455063211741163 2170 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_310 1273-0058 1.06 µM 0.111711240838073 0.459376673469731 no 1523 0.455526183111628 2187 2734232
SGTC_2235 salicylic acid 500 µM 0.111290428663773 0.459511926015866 no 1524 0.455693022538439 2220 338 A COX inhibitor and kinase inhibitor.
SGTC_3176 9106582 49.47 µM 0.110673921058786 0.45971008516445 no 1525 0.455937463444783 2210 17018027
SGTC_2669 eugenol 100 µM 0.110660675028437 0.459714342840911 no 1526 0.455942715585519 2211 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1507 4075-3230 155 µM 0.110646167878625 0.459719005884771 no 1527 0.455948467777494 2220 659771
SGTC_365 0121-0052 13.6 µM 0.107677317288344 0.46067340140379 no 1528 0.457125831531267 2171 3101739
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.107347350645994 0.460779489774127 no 1529 0.457256710576376 2045 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_26 0302-0163 425.158 µM 0.105806093264743 0.461275059999728 no 1530 0.45786810110235 2144 3100915
SGTC_859 0439-0102 54.6 µM 0.105714755748756 0.461304430223601 no 1531 0.457904336281436 2242 610143
SGTC_1567 st069303 68.4 µM 0.103403415088529 0.462047727967055 no 1532 0.458821400914573 2113 5581319
SGTC_1845 st056753 3.01 µM 0.103218566197763 0.462107178777347 no 1533 0.45889475245971 2189 5375839
SGTC_1904 st060225 78 µM 0.10219488987972 0.46243642723899 no 1534 0.459300991903005 2223 66595
SGTC_2349 9023730 187.07 µM 0.101672655562763 0.462604405150301 no 1535 0.459508253671978 2198 4126287
SGTC_706 4262-0057 46.9 µM 0.101335755320768 0.462712773456005 no 1536 0.459641966814647 2210 883298
SGTC_3210 9128157 49.47 µM 0.100861188386205 0.462865428721055 no 1537 0.459830326560942 1979 17590849
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.100727637647855 0.462908389345374 no 1538 0.459883335638703 2199 5106787 A p450 inhibitor.
SGTC_1744 st037937 38.9 µM 0.0988398656451039 0.463515694210119 no 1539 0.460632707621438 2185 1016152
SGTC_3286 9117135 37.221 µM 0.098069557003614 0.463763530522039 no 1540 0.46093853048126 2122 3438150
SGTC_3131 9127911 49.47 µM 0.0975090515834711 0.463943874350178 no 1541 0.461161073181074 2175 45595681
SGTC_1162 k048-0130 20.1 µM 0.0972624328705271 0.464023226802367 no 1542 0.461258994368437 2094 6797406
SGTC_2000 st075254 36.4 µM 0.0969130440141372 0.464135649198172 no 1543 0.461397724972305 2244 17234175
SGTC_679 0422-0091 41.4 µM 0.0968454493435059 0.464157399377888 no 1544 0.461424565093176 2196 627384 YHR062C RPP1
SGTC_355 1311-2252 105 µM 0.0964356233691769 0.464289272843354 no 1545 0.461587300299691 2120 5338538
SGTC_1513 0337-0559 19 µM 0.0962837359303476 0.46433814805587 no 1546 0.461647613958022 2065 775073
SGTC_215 1287-0124 461.5 µM 0.0962319695653574 0.464354805857139 no 1547 0.461668170295643 2238 5560863
SGTC_2676 harmalol 100 µM 0.0960096376497005 0.464426350336354 no 1548 0.461756459094048 2213 5459187 A monoamine oxidase inhibitor
SGTC_1832 st054113 55 µM 0.0955176052611794 0.464584686171087 no 1549 0.461951853608514 2253 1251267
SGTC_2966 9084041 48.03 µM 0.0945966788844153 0.464881054979919 no 1550 0.46231759393691 2177 17741380
SGTC_614 0462-0418 107 µM 0.0934145554003683 0.465261509720662 no 1551 0.462787113771519 2208 5188303
SGTC_1390 3413-2614 145 µM 0.0917719239732028 0.465790227032278 no 1552 0.463439625663972 2145 3421432
SGTC_2734 clemastine 41.6 µM 0.0897455894827366 0.466442530771332 no 1553 0.46424469345899 2261 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_392 N-ethylmaleimide 8.33 µM 0.0882558912303222 0.466922141843187 no 1554 0.464836647898977 2174 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1637 st007924 17.4 µM 0.0868515928115953 0.467374302275787 no 1555 0.465394738695729 2242 683336
SGTC_1021 4476-0760 85.3 µM 0.0858560865822148 0.46769486404664 no 1556 0.465790410192754 2169 746768
SGTC_2762 leflunomide 42.06 µM 0.0855509947095181 0.467793110519747 no 1557 0.46591167805879 2187 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3146 9095609 49.47 µM 0.0788397872432787 0.469954756561805 no 1558 0.468580028439947 2212 17173999
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.078236755331304 0.470149034413248 no 1559 0.468819862541082 2233 688667
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0781918616571676 0.470163498023061 no 1560 0.468837717827543 2226 7104
SGTC_3261 9137475 49.47 µM 0.0779010632960987 0.470257186874991 no 1561 0.468953376797609 2271 17027690
SGTC_2883 9059145 45.46 µM 0.0757758051772724 0.470941948071219 no 1562 0.46979873272024 2255 16476510
SGTC_2835 9006588 71.43 µM 0.0751595328198339 0.471140528063364 no 1563 0.470043890688467 2120 2345538
SGTC_351 caspofungin 25 nM 0.0747169119988369 0.471283157159965 no 1564 0.470219975728275 2195 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1288 0973-0013 65.5 µM 0.0744455483525168 0.47137060256825 no 1565 0.470327933491946 2211 4315430
SGTC_1907 st060210 83.7 µM 0.0716569673819061 0.472269286314718 no 1566 0.47143745156779 2242 688793
SGTC_2699 st077704 54.6 µM 0.071447316509548 0.472336856848137 no 1567 0.471520876335907 2212 645852
SGTC_2607 solasodine 47.35 µM 0.0700042664167282 0.47280197378373 no 1568 0.472095131930642 2209 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1154 4088-0362 150 µM 0.0693447380931204 0.47301456215397 no 1569 0.472357607786195 2275 6618304
SGTC_884 0851-0618 334 µM 0.066966193614204 0.473781311204809 no 1570 0.473304308175637 2275 9642473
SGTC_1209 2323-2347 50.3 µM 0.0637661636504336 0.47481302756387 no 1571 0.47457821045031 2296 5412760
SGTC_125 0133-0007 11.75 µM 0.0616696511329833 0.475489052712967 no 1572 0.475412954419123 2295 26541
SGTC_2878 9043973 25.97 µM 0.0616683924061315 0.475489458613646 no 1573 0.475413455624518 2275 6465167
SGTC_1695 st026914 34.495 µM 0.0616225929066005 0.475504227560302 no 1574 0.475431692297161 2254 3289191
SGTC_2428 5615643 7.78 µM 0.0605746138585486 0.475842178108586 no 1575 0.47584899579678 2256 2253075
SGTC_1008 4106-0037 6 µM 0.059980661369102 0.476033722655682 no 1576 0.476085518473366 2296 2905394
SGTC_2023 5144124 124 µM 0.0593018318788836 0.476252646081792 no 1577 0.476355851028173 2264 2830192
SGTC_2692 st077426 47.7 µM 0.0580941604435879 0.476642139426567 no 1578 0.476836812915051 2289 25238571
SGTC_1264 0783-0040 158 µM 0.0568452204451929 0.477044966011972 no 1579 0.477334245723266 2259 2855798
SGTC_3191 9110352 49.47 µM 0.0567102115159817 0.477088512499238 no 1580 0.477388019747523 2311 17122424
SGTC_2356 9061756 188.97 µM 0.0549143005739354 0.477667800844957 no 1581 0.478103369430087 2295 20104043
SGTC_2519 cryptotanshinone 88.04 µM 0.0546152011581725 0.477764282854955 no 1582 0.478222514030675 2306 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_283 0987-0079 11.7 µM 0.0543306150078546 0.477856084457595 no 1583 0.478335879159196 2288 411556
SGTC_473 2-arachidonoylglycerol 10 µM 0.0541741241638484 0.477906565666338 no 1584 0.478398218163955 2236 5282280 An endocannabinoid.
SGTC_1153 4055-0057 267 µM 0.0525089072366196 0.478443757311249 no 1585 0.479061599089473 2273 882706
SGTC_1320 1313-0481 95.3 µM 0.0521777680700373 0.478550586047003 no 1586 0.479193523654162 2292 6813365 YLR208W SEC13
SGTC_2880 9042983 58.44 µM 0.0516512411209956 0.478720451963635 no 1587 0.479403294644383 2257 6464714
SGTC_1211 1056-0033 32.3 µM 0.0512126220047627 0.478861960376341 no 1588 0.47957804706916 2322 6741922
SGTC_1102 cgs 12066b 26.1 µM 0.0510432410106954 0.478916607216764 no 1589 0.479645532046369 2242 6438352 A 5-HT1B full agonist.
SGTC_2161 5662504 8.5105 µM 0.0505524582839212 0.479074949089423 no 1590 0.479841073572005 2259 2859334
SGTC_2652 actinonin 100 µM 0.0498740417851045 0.479293832923752 no 1591 0.480111381603688 2335 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1934 st074720 32.6 µM 0.0494538167984058 0.479429417161668 no 1592 0.480278820495046 2316 17250992
SGTC_667 1498-1044 59 µM 0.0476742187210327 0.480003624943836 no 1593 0.480987940606464 2259 6739982
SGTC_1815 st051655 58.2 µM 0.04587713345917 0.480583517275024 no 1594 0.481704089919534 2322 5984156
SGTC_3347 9188721 44.724 µM 0.0451351827425084 0.480822945644759 no 1595 0.48199977910693 2264 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1887 st057648 70.8 µM 0.0448342780053383 0.480920049934381 no 1596 0.482119701328241 2318 688672
SGTC_3269 9137823 49.47 µM 0.0445090059893774 0.481025019006831 no 1597 0.482249336675645 2285 17682936
SGTC_887 0885-0007 9.62 µM 0.0442639606071847 0.48110409887839 no 1598 0.482346999385996 2314 5719458
SGTC_2822 7994718 71.43 µM 0.0438977613737003 0.481222278325286 no 1599 0.482492949873739 2329 1018011
SGTC_2178 5812956 200 µM 0.0438962499117338 0.481222766106193 no 1600 0.482493552279141 2333 5403383
SGTC_3193 9111931 49.47 µM 0.0421025758920553 0.481801642450574 no 1601 0.483208463364256 2315 17087244
SGTC_1196 1588-0294 184 µM 0.0413223406787283 0.482053461517427 no 1602 0.483519461496545 2252 6144269
SGTC_2815 7968870 71.43 µM 0.040627604301582 0.482277692066934 no 1603 0.483796388634768 2321 2977326 YHR190W ERG9
SGTC_476 mead acid 10 µM 0.0400880630016212 0.482451836297223 no 1604 0.48401145924876 2328 5312531 An omega 9 fatty acid.
SGTC_765 1319-0117 244 µM 0.0400484779637317 0.482464613034243 no 1605 0.484027238722253 2340 3487746 YGL099W LSG1
SGTC_732 3970-1727 52.7 µM 0.0399784123815634 0.482487227923923 no 1606 0.484055168477596 2324 1275699
SGTC_3241 9133421 49.47 µM 0.0387124790826015 0.482895839628991 no 1607 0.484559811999577 2333 17018221
SGTC_755 1995-0008 37.3 µM 0.0386006020022888 0.482931951631361 no 1608 0.484604411161755 2335 689533
SGTC_72 0744-0168 198.391 µM 0.038538100358978 0.482952126150642 no 1609 0.484629327170506 2221 677577
SGTC_2499 avocadenofuran 51.48 µM 0.0367309985661939 0.483535448041484 no 1610 0.485349746016015 2341 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2351 9026858 72.31 µM 0.0360530849517424 0.483754283749038 no 1611 0.48562001538507 2337 1409300
SGTC_3101 9120531 49.47 µM 0.0356222672317933 0.483893357556487 no 1612 0.485791776452233 2341 24824904
SGTC_3229 9132204 49.47 µM 0.0351751250558665 0.484037703191992 no 1613 0.485970048641519 2319 17682924
SGTC_2346 9031566 143.75 µM 0.0350529439177322 0.48407714585264 no 1614 0.486018761822534 2324 4771086
SGTC_3290 9121031 71.43 µM 0.0343703608299632 0.484297500994503 no 1615 0.48629090906651 2320 17014854
SGTC_2364 9055074 200 µM 0.0336473661940541 0.484530907238141 no 1616 0.486579175435946 2318 6470630
SGTC_623 k072-0108 16.9 µM 0.0335012172485968 0.484578089529917 no 1617 0.486637447577074 2293 5382803
SGTC_2350 9023895 38.85 µM 0.0333320527585636 0.484632702361362 no 1618 0.486704896774597 2308 2997209
SGTC_1341 1486-1360 280 µM 0.0311840225499811 0.485326194204291 no 1619 0.487561390938082 2356 3976547
SGTC_20 0481-0013 4.944 µM 0.0310358738578889 0.485374025689647 no 1620 0.487620465121322 2343 182045
SGTC_2186 6124449 200 µM 0.030790526644224 0.485453239282491 no 1621 0.487718297741121 2334 3834182 YLR033W RSC58
SGTC_44 0929-0055 61.211 µM 0.0297728502196699 0.485781815669375 no 1622 0.488124105775422 2314 1379590
SGTC_371 0195-0006 7.36 µM 0.0286669389110729 0.486138891321646 no 1623 0.488565112225993 2320 3928593
SGTC_1261 0712-0010 12.7 µM 0.0282497877518449 0.486273583616241 no 1624 0.488731464083489 2327 2840123
SGTC_479 n-linoleoylglycine 10 µM 0.0280779301331175 0.486329074502113 no 1625 0.488799998167615 2349 6433346 An anti-infammatory.
SGTC_2504 purpurogallin 52.29 µM 0.0280175007258529 0.486348586538801 no 1626 0.488824096532502 2319 5281571 An antioxidant.
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.0270051428281292 0.486675471358813 no 1627 0.489227816072481 2368 6708630 An antioxidant.
SGTC_2059 5238311 157 µM 0.0258103628192668 0.487061270780298 no 1628 0.489704298134488 2351 703021
SGTC_1229 0139-0193 12.2 µM 0.0234306294162428 0.487829732292017 no 1629 0.490653386483672 2366 3090752
SGTC_1723 st034307 2.5525 µM 0.0228943631487094 0.488002909285165 no 1630 0.490867268387134 2358 867466
SGTC_2623 humulene 100 µM 0.0220952995055133 0.488260955879844 no 1631 0.491185968006676 2334 6187145 An anti-inflammatory.
SGTC_1174 0739-0097 51.1 µM 0.0207421546983681 0.488697946503171 no 1632 0.491725670828849 2362 728447
SGTC_2853 9015042 58.44 µM 0.0204093828940119 0.488805415413775 no 1633 0.491858399471597 2360 6457456
SGTC_784 4579-0127 173 µM 0.0168193266474198 0.489964876911178 no 1634 0.49329037582127 2378 1948547
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0167959631609468 0.489972422781334 no 1635 0.493299695187402 2354 2724 A muscle relaxant with antifungal properties.
SGTC_965 1291-5240 308 µM 0.0160408648702642 0.490216304124017 no 1636 0.493600895215133 2374 2834598
SGTC_1852 st056254 31.4 µM 0.0156964605980322 0.490327540897682 no 1637 0.493738275341959 2316 442583
SGTC_2224 6650123 117.647 µM 0.0154539902776373 0.490405855175163 no 1638 0.493834995272028 2380 2908370
SGTC_3000 9075062 71.4286 µM 0.0133169928033055 0.491096088968361 no 1639 0.494687445546859 2380 17057871
SGTC_1457 k015-0032 57.3 µM 0.0131211872873069 0.491159334012926 no 1640 0.494765553821014 2383 4302660
SGTC_2427 5545055 42.75 µM 0.0130687747594932 0.491176263260486 no 1641 0.494786461601685 2375 5372858
SGTC_1964 st076914 61 µM 0.0123698869750898 0.491402005536263 no 1642 0.49506525492977 2381 24208661
SGTC_860 0443-0016 25.1 µM 0.0122185867984971 0.491450876187775 no 1643 0.495125610405702 2391 5337942
SGTC_983 1491-0821 12.2 µM 0.0116897234074879 0.491621702494055 no 1644 0.495336581295873 2380 46495113
SGTC_2569 tetrandrine 100 µM 0.0111010034685348 0.491811864659624 no 1645 0.495571431318806 2373 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1919 st067113 52.3 µM 0.0107284820847537 0.491932193590139 no 1646 0.495720036996211 2371 1268243
SGTC_2591 skatole 100 µM 0.0104831558981946 0.492011437329041 no 1647 0.495817902479998 2371 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1026 k007-1105 30.6 µM 0.0100947711483931 0.492136891598664 no 1648 0.495972837375647 2388 7066794
SGTC_1235 benzylparaben 21.5 µM 0.00890682390692352 0.492520621670794 no 1649 0.496446738340437 2367 7180
SGTC_1531 st059297 52.4 µM 0.00866233230108037 0.492599598086922 no 1650 0.496544272615593 2392 7566702
SGTC_3264 9137442 49.47 µM 0.00842948897934485 0.492674812108908 no 1651 0.496637160269158 2383 17015726
SGTC_281 1672-3440 14.9 µM 0.00696932988149178 0.493146484627651 no 1652 0.497219662151783 2375 6833000
SGTC_2315 7733312 200 µM 0.00365769139969679 0.494216271618576 no 1653 0.498540795505712 2396 726316
SGTC_385 1494-0393 12.4 µM 0.00323877646904509 0.49435160042606 no 1654 0.49870791738865 2393 3090647
SGTC_1375 2910-0797 186 µM 0.00288572758873395 0.494465651972526 no 1655 0.49884876285294 2397 742508
SGTC_2759 disulfiram 3.38 µM 6.53645443064115e-06 0.495395783433201 no 1656 0.499997392331964 2405 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1298 1079-1278 263 µM 0 0.495397895085094 no 1657 0.5 2405 2840950
SGTC_158 k038-0087 26.446 µM -0.000401910137203622 0.495527735492474 no 1658 0.499839661057664 2408 X158
SGTC_555 4296-0685 37 µM -0.000865274573647701 0.495677429808654 no 1659 0.49965480543149 2407 2908540 YHR072W ERG7
SGTC_3065 9113888 49.47 µM -0.00101484738259594 0.495725750867148 no 1660 0.499595134540424 2410 16648368
SGTC_1917 st066507 28.5 µM -0.00261199845195952 0.496241730972736 no 1661 0.498957964566058 2383 3156428
SGTC_1956 st077085 54 µM -0.00464293404613758 0.496897859691755 no 1662 0.49814774395868 2420 24208685
SGTC_962 1254-0300 21.5 µM -0.00532972575116035 0.497119741566768 no 1663 0.497873757121257 2417 7340576
SGTC_3090 9117696 49.47 µM -0.00732431406209591 0.497764138245754 no 1664 0.497078047570685 2460 7923821
SGTC_1172 0370-0043 85 µM -0.0074100242702014 0.497791829001723 no 1665 0.497043855072735 2429 376585
SGTC_3129 9127257 49.47 µM -0.00765327330570595 0.497870416544083 no 1666 0.496946815500404 2433 837894
SGTC_1296 1068-0102 11.9 µM -0.008502679294469 0.498144838524034 no 1667 0.49660796260433 2427 767053
SGTC_2074 5212007 75.395 µM -0.0089739210966488 0.498297085433925 no 1668 0.496419971504326 2415 758611
SGTC_1625 st003711 30.1 µM -0.00911492740227513 0.498342641234365 no 1669 0.496363720428016 2421 24207034 YER133W GLC7
SGTC_1975 st070967 30.8 µM -0.00918215604568147 0.498364361225732 no 1670 0.496336901202064 2426 261391
SGTC_1246 0422-0085 105 µM -0.0101419157875102 0.498674437492382 no 1671 0.495954030348575 2423 264295
SGTC_1922 5578187 25 µM -0.0104271260065537 0.498766582507773 no 1672 0.495840253951084 2428 1350412
SGTC_2915 7971052 15.16 µM -0.011182475729126 0.49901061934135 no 1673 0.495538930606741 2428 5741558
SGTC_2870 9038528 12.99 µM -0.0126750403330824 0.499492835042528 no 1674 0.494943525898399 2491 6463316
SGTC_800 3448-7362 155 µM -0.0135352781476375 0.499770759863798 no 1675 0.494600370142494 2426 15991913
SGTC_2873 9040596 71.43 µM -0.0142448259877571 0.5 no 1676 0.49431732882044 2487 6463863
SGTC_1422 4031-0024 15.5 µM -0.0157526325571644 0.499512859180286 no 1677 0.493715868742805 2425 782427
SGTC_2179 6298986 200 µM -0.0175327500006603 0.498937741394224 no 1678 0.493005803067766 2453 738374
SGTC_199 4063-0024 41.6 µM -0.0179153186332749 0.498814141917424 no 1679 0.492853204236678 2496 306215
SGTC_3011 9081274 71.4286 µM -0.0182140013206276 0.498717644215578 no 1680 0.492734066525518 2461 6625322
SGTC_1749 st037932 54.2 µM -0.0208708126905924 0.497859291787514 no 1681 0.491674354824876 2484 594497
SGTC_3093 9117344 49.47 µM -0.0221514966114707 0.497445536632789 no 1682 0.491163554090934 2548 24824913
SGTC_467 ro 31-8220 72.8 µM -0.0222590544810232 0.497410787644398 no 1683 0.491120655286652 2438 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1387 3342-1166 1.8 µM -0.0224375500785558 0.4973531206713 no 1684 0.491049463626462 2483 3418228
SGTC_1122 capsaicin 818.572 nM -0.02267499967751 0.497276407382646 no 1685 0.490954759037425 2493 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1596 piperlongumine 63 µM -0.0237675971881039 0.496923421191117 no 1686 0.490518993221214 2443 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_457 grayanotoxin iii 135 µM -0.0240536028585632 0.496831021538866 no 1687 0.490404926078933 2475 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_802 4112-3352 742 µM -0.0253617266181549 0.496408409151476 no 1688 0.489883219507492 2554 704594
SGTC_273 hydroxyurea 18.1 mM -0.0262491905485193 0.496121700586201 no 1689 0.489529290499072 2446 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2412 st077135 33.4 µM -0.0262637133358226 0.496117008797675 no 1690 0.489523498741954 2620 13258915
SGTC_322 k048-0136 19.3 µM -0.0271346475872808 0.495835642373742 no 1691 0.489176170074603 2500 6823282
SGTC_1469 k284-2957 126 µM -0.0273675495522715 0.495760400767153 no 1692 0.489083290127556 2482 23884841
SGTC_1719 st032227 49.2 µM -0.0277023510947594 0.49565223961769 no 1693 0.488949774261027 2468 3125804
SGTC_3194 9111903 49.47 µM -0.0280393412723445 0.495543371729474 no 1694 0.488815386836886 2495 17087251
SGTC_440 fluspirilene 35.1 µM -0.0286231752276266 0.495354759396899 no 1695 0.48858256424816 2647 3396 An atypical antipsychotic.
SGTC_671 0560-0003 407 µM -0.0288928745726928 0.495267631166545 no 1696 0.48847501425915 2502 3238678
SGTC_2531 methyl deoxycholate 70.07 µM -0.0293445388830704 0.495121718408965 no 1697 0.488294902645147 2472 16667744 Haematoxylin.
SGTC_83 0170-0301 39.027 µM -0.0315552122441587 0.494407557423707 no 1698 0.487413380518834 2457 3089716
SGTC_932 2857-0803 154 µM -0.0318363301496213 0.494316743145257 no 1699 0.487301287020872 2624 674898
SGTC_841 0251-0215 91.2 µM -0.0322039491279401 0.494197985405284 no 1700 0.487154703432728 2512 3888614
SGTC_2903 5923464 63.88 µM -0.0324428904926112 0.494120796693582 no 1701 0.487059429404371 2468 2876576
SGTC_2007 4011539 71.82 µM -0.033324015666331 0.493836155910867 no 1702 0.486708101330263 2464 45595301
SGTC_1253 0550-0034 176 µM -0.0339045662917605 0.493648615154889 no 1703 0.486476625954455 2509 5969915
SGTC_531 3788-1495 174 µM -0.0345846712181452 0.493428916220635 no 1704 0.486205462391986 2472 2896655
SGTC_1600 coumarin 106 71.1 µM -0.0346253128852964 0.493415787528078 no 1705 0.486189258417694 2596 100336 A hepatotoxic, DNA x-linker.
SGTC_2586 curcumin 80 µM -0.0347833481960815 0.493364736614229 no 1706 0.486126249405648 2488 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_5 0352-0601 109.883 µM -0.0356657802303315 0.493079682330212 no 1707 0.485774428301253 2420 762456
SGTC_533 1222-0222 6.71 µM -0.0365457205829031 0.492795436459238 no 1708 0.485423611642952 2615 3982874
SGTC_1145 3546-0597 10.2 µM -0.0370920693941073 0.492618952017394 no 1709 0.485205797692744 2512 875334
SGTC_3265 9137266 49.47 µM -0.0374030016249714 0.492518513709757 no 1710 0.485081839698197 2471 17224265
SGTC_2457 5731572 11.68 µM -0.0401842599326916 0.491620124745738 no 1711 0.483973113124274 2472 2865357
SGTC_2955 9076254 12.21 µM -0.0406756350210473 0.491461407366466 no 1712 0.483777242976174 2469 16459619
SGTC_3295 9122362 53.5725 µM -0.0414748975051326 0.491203243236288 no 1713 0.483458652259544 2510 4730473
SGTC_316 k060-0003 58.6 µM -0.0463417184071858 0.489631329279869 no 1714 0.481518944264405 2569 6152314
SGTC_1972 st070201 17.4 µM -0.046978300426933 0.489425733724436 no 1715 0.481265261090408 2506 2829099
SGTC_212 3807-4682 38.772 µM -0.0470944541738195 0.489388220094712 no 1716 0.481218973681718 2540 3125501 YBL034C STU1
SGTC_3297 9117502 71.43 µM -0.048000074229482 0.489095739486652 no 1717 0.480858091725055 2478 7453720
SGTC_2702 st077768 96.8 µM -0.04933143253998 0.488665772412214 no 1718 0.480327585229874 2549 6484119
SGTC_557 1315-0110 16.2 µM -0.0511209435202473 0.488087864085995 no 1719 0.479614573647499 2502 6833801
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0513067379914412 0.488027864652888 no 1720 0.479540549518635 2565 616764
SGTC_578 3460-0051 92 µM -0.0514923103551099 0.487967937216423 no 1721 0.479466614586092 2496 2876744
SGTC_3235 9132602 49.47 µM -0.0524513872056128 0.48765822403082 no 1722 0.479084514683397 2568 4912240
SGTC_2167 5876490 200 µM -0.0538662066315786 0.487201352251346 no 1723 0.47852088038023 2692 686534
SGTC_2448 5185112 27.17 µM -0.053886568244131 0.48719477722519 no 1724 0.478512769052866 2566 5718189
SGTC_1829 berberine 14.4 µM -0.0540056741758719 0.487156316460184 no 1725 0.478465321751319 2631 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_348 k064-0012 10.7 µM -0.0540798767229789 0.487132355608737 no 1726 0.478435762415322 2477 5066323
SGTC_1365 1672-3266 55.4 µM -0.0546030081650305 0.486963431803743 no 1727 0.478227371083521 2493 6415873
SGTC_1291 0993-0025 5.79 µM -0.0546288946692614 0.486955072881302 no 1728 0.478217059253557 2542 4353356
SGTC_1839 st053978 48 µM -0.0567488941638142 0.486270530893095 no 1729 0.477372612416005 2492 3788398
SGTC_1946 st076057 65.1 µM -0.0573432168237508 0.486078632918985 no 1730 0.477135897460871 2514 953009
SGTC_778 3456-2434 196 µM -0.0574646325634816 0.486039429972118 no 1731 0.477087539329602 2648 5539063
SGTC_357 1325-0123 420 µM -0.0578305904446624 0.485921269607414 no 1732 0.476941785647839 2500 1098503
SGTC_3220 9131269 49.47 µM -0.0587409747318559 0.485627330401761 no 1733 0.476579211274841 2499 17722206
SGTC_99 0109-0120 622.8 µM -0.0589694109006281 0.485553575574387 no 1734 0.476488236131404 2517 759414
SGTC_2281 7943571 200 µM -0.0594235570574482 0.485406947587672 no 1735 0.476307375195882 2532 1244024
SGTC_856 0433-0016 11.3 µM -0.0600875663730117 0.485192565648507 no 1736 0.47604294633352 2568 3911780
SGTC_797 k781-0471 270 µM -0.0601527798517552 0.485171511065214 no 1737 0.476016976894464 2578 23738129
SGTC_1757 st041620 31.8375 µM -0.0604987691459114 0.48505980693032 no 1738 0.475879198067661 2550 5289815
SGTC_1604 st002052 72.4 µM -0.0611089403318148 0.48486281339539 no 1739 0.475636224552233 2637 6254834 YHR062C RPP1
SGTC_1437 4092-1038 11.6 µM -0.0624119719560104 0.484442142561359 no 1740 0.475117380652616 2521 3977136
SGTC_2594 a-mangostin 100 µM -0.0630430395981353 0.484238414828027 no 1741 0.47486611590984 2593 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_441 propafenone 146 µM -0.0637034285185889 0.484025225705324 no 1742 0.474603187365646 2510 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0643302804545661 0.483822867336117 no 1743 0.474353621533262 2545 279621
SGTC_2325 6158266 200 µM -0.0649174714587292 0.483633315962696 no 1744 0.474119854861864 2576 3623240
SGTC_1103 duloxetine 36.1 µM -0.0650721209089297 0.483583394122686 no 1745 0.474058288832439 2639 60835 A selective serotonin reuptake inhibitor.
SGTC_39 0986-0283 58.349 µM -0.0654255844386085 0.48346929478303 no 1746 0.473917577139517 2556 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_989 1501-0895 10.3 µM -0.0685857788688767 0.482449233542693 no 1747 0.472659669513767 2508 2830112
SGTC_2726 cimetidine 79.27 µM -0.070847794180646 0.481719160602158 no 1748 0.471759446554416 2532 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_92 0063-0024 660.874 µM -0.0722192438415812 0.481276550372563 no 1749 0.471213715394869 2505 3594437
SGTC_2093 5331342 194.4 µM -0.0727532559271407 0.481104213977105 no 1750 0.471001234347061 2549 33839
SGTC_1368 1852-0141 284 µM -0.072947898684709 0.481041399737295 no 1751 0.470923788904011 2597 2838987
SGTC_1838 st055369 84.5 µM -0.0748018589403773 0.480443121794953 no 1752 0.47018618137154 2526 676036
SGTC_632 0781-2353 4.65 µM -0.074877825333929 0.48041860816649 no 1753 0.470155959919098 2605 6811515 YHR007C ERG11
SGTC_250 brefeldin a 552.239 µM -0.0749205439911517 0.480404823296998 no 1754 0.470138965376228 2522 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_573 3702-0553 84.7 µM -0.0750842784825179 0.480351988084844 no 1755 0.470073828232827 2546 1222756
SGTC_939 1165-0479 45.3 µM -0.0788344268357323 0.479141955259777 no 1756 0.468582160297796 2558 1377347
SGTC_36 0335-0881 14.2 µM -0.0795238040959281 0.478919539547153 no 1757 0.468307999318493 2537 23828853
SGTC_2270 7924575 90.91 µM -0.0807440404155159 0.478525867428512 no 1758 0.467822755974183 2709 1262135
SGTC_2801 7907800 81.82 µM -0.0824526532192275 0.477974670788711 no 1759 0.467143383666293 2619 6620925
SGTC_908 3448-7491 47.7 µM -0.0851611833293784 0.477100988651794 no 1760 0.466066624824517 2558 1203031
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0860364386708488 0.476818683583273 no 1761 0.465718725368167 2549 77254
SGTC_1042 0350-0096 82 µM -0.0879812828029244 0.476191434940148 no 1762 0.464945776302575 2538 3122515
SGTC_1135 dihydrocapsaicin 536.708 nM -0.0880928042482184 0.476155468959728 no 1763 0.464901457762 2543 107982 A Capsaicinoid.
SGTC_771 0250-0039 27.3 µM -0.0886590555230439 0.475972854331115 no 1764 0.464676436649937 2559 3005115
SGTC_2522 biochanin a 4.94 µM -0.0895259039557961 0.475693307655432 no 1765 0.464331983928023 2614 5280373 A possible chelator.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0896484396800821 0.475653792534665 no 1766 0.464283295024529 2653 5024745
SGTC_1328 1441-0025 69.2 µM -0.089951546583492 0.475556048143735 no 1767 0.464162859444618 2559 4562601
SGTC_1043 0916-0009 19.3 µM -0.0905955656217812 0.475348373011291 no 1768 0.463906977782458 2548 3101130
SGTC_3211 9128781 49.47 µM -0.0913789303853371 0.475095772460711 no 1769 0.46359575140688 2706 17194361
SGTC_1756 st041558 35.5 µM -0.0914591268999119 0.475069913188577 no 1770 0.46356389104057 2626 3955792
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0917178561680553 0.474986486955786 no 1771 0.463461105009795 2612 1273210
SGTC_109 0132-0036 33.701 µM -0.0931507275761651 0.474524483172833 no 1772 0.462891908906372 2556 67274 A color developer.
SGTC_955 1216-0110 33 µM -0.0942020818715493 0.474185514520065 no 1773 0.462474315518027 2553 3619719
SGTC_3238 9133470 49.47 µM -0.0948559209443053 0.473974718731987 no 1774 0.462214634288601 2588 3534688
SGTC_2245 6637752 200 µM -0.0962408850497641 0.473528234526361 no 1775 0.461664629964281 2701 681890
SGTC_1353 1498-1206 8.11 µM -0.0969320393880383 0.473305432854388 no 1776 0.46139018242512 2573 6756808
SGTC_3115 9123671 49.47 µM -0.0970044500917479 0.473282090900534 no 1777 0.461361430228282 2568 3286988
SGTC_2468 5987765 72.9 µM -0.097117019175113 0.47324580387359 no 1778 0.461316732701058 2652 26772094
SGTC_590 k048-0076 22.4 µM -0.0971300125897651 0.473241615416464 no 1779 0.461311573469518 2646 6832814
SGTC_2411 st077133 39.94 µM -0.0974087277502413 0.473151771655932 no 1780 0.461200906974575 2870 1403142 YNL221C POP1
SGTC_2046 4110841 106 µM -0.0979535102927791 0.472976165090962 no 1781 0.460984604588426 2608 44119630 YMR134W ERG29
SGTC_913 3487-1245 167 µM -0.0983661332389126 0.472843162673856 no 1782 0.460820782993962 2575 4016153
SGTC_2362 9071156 126 µM -0.0986112567703201 0.472764152450747 no 1783 0.46072346598863 2684 653133
SGTC_745 0469-0705 296 µM -0.099383458120488 0.472515257210444 no 1784 0.460416908121876 2638 3486736
SGTC_329 k048-0121 21.3 µM -0.0997744789638453 0.472389227812954 no 1785 0.460261684881476 2661 6832902
SGTC_3203 9113543 49.47 µM -0.100936648218272 0.472014666983384 no 1786 0.459800375292975 2738 17018012
SGTC_685 1278-0033 54.9 µM -0.102715587663261 0.471441372524621 no 1787 0.459094350958178 2609 3590572
SGTC_160 3453-0671 289.699 µM -0.105358285825299 0.470589826255597 no 1788 0.458045757436402 2616 5322268
SGTC_3144 9087057 49.47 µM -0.105987379483615 0.470387135541292 no 1789 0.45779618274801 2557 17249618
SGTC_1104 tacrolimus 29.8 µM -0.107397096245494 0.46993296004831 no 1790 0.457236979022441 2583 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2463 5473429 200 µM -0.108080473903539 0.469712806893422 no 1791 0.456965928489625 2663 5399405
SGTC_411 enrofloxacin 100 µM -0.108215974917794 0.46966915573621 no 1792 0.456912186610348 2700 71188 A bacterial gyrase inhibitor.
SGTC_556 4058-0063 51.5 µM -0.10873248716328 0.469502766549014 no 1793 0.456707336790763 2610 6615692
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.10879069039098 0.469484017302191 no 1794 0.456684253991095 2655 75037 A free radical scavenger.
SGTC_1292 0kpi-0043 232 µM -0.109261928329698 0.469332217968438 no 1795 0.456497371274934 2641 3333905
SGTC_2280 7785178 200 µM -0.10984727444006 0.469143667310816 no 1796 0.456265249143609 2624 2954328
SGTC_1074 carmofur 3.8 µM -0.110214554013086 0.469025363392431 no 1797 0.456119610079445 2589 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2904 7225135 42.03 µM -0.110348045802148 0.468982365212846 no 1798 0.456066677423963 2687 4446116
SGTC_1105 epirubicin 18.1 µM -0.11165226180157 0.4685622917156 no 1799 0.455549566061694 2608 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1267 0828-0272 9.49 µM -0.113129941807995 0.468086389702129 no 1800 0.45496376861794 2696 745334
SGTC_2781 5567276 71.43 µM -0.11422807670996 0.467732753586075 no 1801 0.454528497788103 2766 2853274
SGTC_825 1988-2224 89.6 µM -0.115920315401443 0.467187846159364 no 1802 0.453857847437191 2621 1180859
SGTC_3118 9124250 49.47 µM -0.117285202152321 0.466748392075432 no 1803 0.453317025533476 2685 1504786
SGTC_1777 st045864 34.765 µM -0.118624869492366 0.466317097324963 no 1804 0.452786280731795 2626 4691462
SGTC_381 3461-2219 42.7 µM -0.120602136714938 0.465680605012756 no 1805 0.452003088172413 2677 2883159
SGTC_2864 9034755 47.6 µM -0.121657441568784 0.465340932870766 no 1806 0.45158515975263 2598 4930451
SGTC_472 calcifediol 10 µM -0.122647885309477 0.465022160613039 no 1807 0.45119296683499 2698 5283731 A vitamin D metabolite.
SGTC_65 0798-0905 34.986 µM -0.124622294837023 0.464386768185363 no 1808 0.450411288633865 2953 3602145
SGTC_452 diindolylmethane 8 µM -0.124732547363729 0.46435129005194 no 1809 0.450367644771218 2716 3071 Inhibits expression of several cancer promoting factors.
SGTC_455 paf C-16 10 µM -0.126140056187025 0.463898393137094 no 1810 0.449810530217132 2626 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2231 micatex 6.853 µM -0.126545484527159 0.463767946305293 no 1811 0.449650073480841 2656 20737 An antifungal of unknown mechanism.
SGTC_2610 ononetin 44.17 µM -0.126546662027301 0.463767567449524 no 1812 0.449649607472534 2711 259632
SGTC_1939 st074455 53.6 µM -0.126613058198603 0.463746204810942 no 1813 0.449623330588206 2812 1644229
SGTC_821 1114-0266 29.2 µM -0.126979730341238 0.463628231753154 no 1814 0.449478220758355 2700 3123235
SGTC_1385 3091-4834 14.1 µM -0.127191056806647 0.463560241049858 no 1815 0.449394591763907 2736 4072814
SGTC_1676 st018489 23.4 µM -0.127191191419078 0.463560197740932 no 1816 0.449394538493953 2700 3696235
SGTC_390 dec-rvkr-cmk 16.7 µM -0.127671906858037 0.46340553967671 no 1817 0.449204311597886 2697 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2015 5119600 184 µM -0.12982428374849 0.462713134864271 no 1818 0.44835272492631 2757 2828786
SGTC_735 3076-0345 636 µM -0.130565318833726 0.462474775018663 no 1819 0.448059589685917 2736 2888990
SGTC_3187 9109394 49.47 µM -0.130845710481923 0.462384588317851 no 1820 0.447948681038392 2664 17098090
SGTC_1195 1502-0147 41.1 µM -0.132246917367918 0.46193392555364 no 1821 0.447394496143857 2641 817940
SGTC_417 st075190 100 µM -0.132467958199855 0.461862837806953 no 1822 0.447307082649932 2723 222757
SGTC_1010 4112-3296 15.2 µM -0.132528305035524 0.461843430199076 no 1823 0.447283218147466 2752 704384
SGTC_2207 7258803 200 µM -0.134831923098897 0.461102652483746 no 1824 0.446372382656572 2715 3666799
SGTC_1989 st071868 50.2 µM -0.135694397112085 0.460825340079488 no 1825 0.446031438604402 2763 16414057
SGTC_2266 7929956 200 µM -0.138450961232099 0.459939146790504 no 1826 0.444942011771448 2632 2967153
SGTC_1769 st044406 64.4 µM -0.141046377595925 0.459104941830377 no 1827 0.443916652255319 2659 670903
SGTC_141 0443-0274 32.331 µM -0.14748697045048 0.457035626117384 no 1828 0.441373831669421 2748 1627241
SGTC_1139 k015-0024 46.9 µM -0.148569799609311 0.456687833788218 no 1829 0.440946552452166 2647 2766652
SGTC_3182 9108849 49.47 µM -0.14892547788529 0.456573601223259 no 1830 0.440806218474744 2737 17133045
SGTC_185 k048-0037 25.491 µM -0.149260764897177 0.456465920970513 no 1831 0.440673936740329 2659 6827589
SGTC_1860 st056228 74.6 µM -0.150153967782587 0.456179076951238 no 1832 0.440321571223503 2790 688679
SGTC_487 nimodipine 119 µM -0.150276656778965 0.456139678271398 no 1833 0.440273174514539 2689 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2044 5102272 200 µM -0.150849475882029 0.455955736628914 no 1834 0.440047228341079 2761 592666
SGTC_911 3456-4043 236 µM -0.150875257097759 0.455947458077883 no 1835 0.440037059503605 2763 914281
SGTC_2767 sibutramine 71.45 µM -0.151100996238123 0.455874972282674 no 1836 0.439948023320045 2781 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2992 9074591 71.4286 µM -0.153724542872953 0.45503264867504 no 1837 0.438913466191211 2690 17741321
SGTC_1874 staurosporine 7.6 µM -0.155284465317779 0.454531910961323 no 1838 0.438298530969883 2793 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2910 7948405 25.97 µM -0.155342361919526 0.45451332744095 no 1839 0.438275710475023 2771 2971328
SGTC_1240 0356-0016 42.1 µM -0.157296488466122 0.453886154967913 no 1840 0.437505593804463 2764 4305613
SGTC_2467 5474540 200 µM -0.157420641085116 0.453846312335048 no 1841 0.437456673515662 2677 5413519
SGTC_279 1273-0055 2.93 µM -0.157691531597296 0.453759380693467 no 1842 0.437349936903762 2761 2847562
SGTC_1993 st073995 70.8 µM -0.157988978008789 0.45366392953382 no 1843 0.437232741955868 2716 3098394
SGTC_599 1935-0052 86.5 µM -0.158363839146895 0.453543639643393 no 1844 0.437085053174373 2676 9557311
SGTC_373 0844-0104 25.9 µM -0.158977366295847 0.453346772972246 no 1845 0.436843353053654 2789 5375804
SGTC_2673 kobusone 100 µM -0.159535897780566 0.45316756310557 no 1846 0.436623339069794 2696 6710676 An epoxy ketone and protein crosslinker.
SGTC_1056 3448-1962 115 µM -0.160346949811227 0.452907346733212 no 1847 0.43630388835047 2795 715507
SGTC_2210 7115885 190.385 µM -0.160512054346304 0.452854377385642 no 1848 0.436238863372513 2693 2927039
SGTC_3134 9127454 49.47 µM -0.161679603964361 0.452479824502691 no 1849 0.435779083440459 2683 24262820
SGTC_1739 st037196 92.5 µM -0.162162537300939 0.452324910604577 no 1850 0.435588930087891 2796 612214
SGTC_1032 k061-1018 98.7 µM -0.162596581688608 0.452185685347878 no 1851 0.435418039296937 2900 4005393
SGTC_2625 euphol 100 µM -0.163632624992794 0.451853385081324 no 1852 0.435010179917113 2814 6708538 A triterpene alcohol.
SGTC_432 NS 1619 61.3 µM -0.164671405922443 0.451520240612175 no 1853 0.434601312229098 2871 4552 A K+/calcium channel activator.
SGTC_2137 5261020 140 µM -0.167069876016391 0.450751164910312 no 1854 0.43365753415157 2689 763655
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.167851501504873 0.450500574454444 no 1855 0.433350052439739 2700 442882
SGTC_2934 9036370 36.88 µM -0.16833572910354 0.450345340157899 no 1856 0.433159583570163 2811 6462800
SGTC_2129 girgensonine 121.053 µM -0.169082534981613 0.450105943084377 no 1857 0.432865861100358 2775 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_948 3448-0295 75.3 µM -0.169267769883537 0.450046566747428 no 1858 0.43279301302529 2709 678569
SGTC_202 3594-0513 34.79 µM -0.170122796224995 0.449772505848953 no 1859 0.432456783018478 2686 708429
SGTC_1809 st050081 57.6 µM -0.170189928915068 0.449750988874912 no 1860 0.432430385870255 2854 5036894
SGTC_1161 k007-0610 110 µM -0.170435410813161 0.449672309722454 no 1861 0.432333862855839 2783 5843850
SGTC_793 0488-0545 106 µM -0.170827270707432 0.449546719208971 no 1862 0.432179792662929 2696 292548
SGTC_1790 st045711 43.5 µM -0.172456758921797 0.449024525002193 no 1863 0.431539226679678 2821 585119
SGTC_1865 st057639 52.2 µM -0.172797708624759 0.448915273638861 no 1864 0.4314052191019 2678 688818
SGTC_3175 9106517 49.47 µM -0.174578698204999 0.448344649855041 no 1865 0.430705343942532 2804 41468073
SGTC_2359 9039622 200 µM -0.174795635181931 0.448275151167677 no 1866 0.430620109079193 2715 6463596
SGTC_2184 6075246 200 µM -0.17640544344106 0.447759477112866 no 1867 0.429987714240008 2773 2267320
SGTC_2657 nystatin 74.44 µM -0.176477530815548 0.44773638723589 no 1868 0.429959399724596 2756 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_865 0488-0499 301 µM -0.177160251173433 0.447517717941835 no 1869 0.429691258357254 2712 9634651
SGTC_2837 9008476 45.46 µM -0.178023371824649 0.447241290866648 no 1870 0.429352310427271 2925 2992805
SGTC_1669 st015249 58.4 µM -0.178212358639982 0.44718076847643 no 1871 0.429278102147521 2780 722793
SGTC_369 0957-0393 4.5 µM -0.178699021137208 0.447024922118224 no 1872 0.429087018916188 2778 6997992
SGTC_1057 3448-5381 134 µM -0.179800078455514 0.446672355269106 no 1873 0.428654761010963 2859 5497911
SGTC_127 0180-0333 59.125 µM -0.181217635828027 0.446218504817828 no 1874 0.428098376194238 2685 771601
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.181822310369903 0.44602493136295 no 1875 0.427861087607078 2701 2333 A French combination drug.
SGTC_412 gemfibrozil 100 µM -0.182640927251856 0.445762889407252 no 1876 0.427539884567522 2747 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_165 k038-0023 64.381 µM -0.182943931886555 0.44566590262844 no 1877 0.427421005940886 2751 46368543
SGTC_990 3985-0011 41.3 µM -0.183398865843017 0.44552029189043 no 1878 0.427242532850528 2807 5399565 YGL099W LSG1
SGTC_3206 9114350 49.47 µM -0.183599132931714 0.44545619472004 no 1879 0.427163971689491 2843 17087243
SGTC_2407 paclitaxel 400 µM -0.18366129145343 0.445436300650899 no 1880 0.427139588611589 2986 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2518 prenyletin 46.28 µM -0.183717631789682 0.445418268832649 no 1881 0.427117488088262 2809 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2026 5148700 152 µM -0.183926390853481 0.445351456131962 no 1882 0.427035600536899 2716 79838
SGTC_2384 9036245 200 µM -0.189162488742879 0.443676171611912 no 1883 0.424982733247838 2797 6462766
SGTC_2293 7624732 200 µM -0.189532319939324 0.443557882164763 no 1884 0.424837813240415 2709 894453
SGTC_2976 9009005 19.48 µM -0.189684284793313 0.443509278099398 no 1885 0.424778268076497 2956 2993148
SGTC_350 k064-0020 19.8 µM -0.189978584910418 0.44341515229058 no 1886 0.424662955842246 2928 2790705
SGTC_906 1165-0455 526 µM -0.190068730406125 0.443386321755706 no 1887 0.424627636457533 2736 3252859
SGTC_2087 5276107 200 µM -0.190700325302617 0.443184332071669 no 1888 0.42438019190701 2728 144405
SGTC_3158 9100007 49.47 µM -0.190798967605514 0.44315278671456 no 1889 0.424341548779041 2763 19297233
SGTC_503 tyrphostin 8 294 µM -0.191509747275662 0.442925493292281 no 1890 0.424063122324669 2848 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3076 9116187 49.47 µM -0.192683202953107 0.442550286275083 no 1891 0.423603539521326 2863 27241210
SGTC_1776 st049249 45.9 µM -0.192885103068833 0.442485734834047 no 1892 0.423524475991933 2784 1822314
SGTC_1033 k072-0102 21.3 µM -0.192924605789439 0.442473105215276 no 1893 0.423509007195354 2900 5965931
SGTC_2347 9049783 174.81 µM -0.195186340555225 0.441750092211781 no 1894 0.422623536031708 2901 6467988 YPL169C MEX67
SGTC_3310 9130229 44.1445 µM -0.196057921017668 0.441471524109564 no 1895 0.422282415590683 2914 7761258
SGTC_2505 galangin 7.89 µM -0.196085991803214 0.441462552813135 no 1896 0.422271430172914 2716 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3342 9147791 14.508 µM -0.196428030908083 0.441353241072069 no 1897 0.422137579054306 2745 1838168
SGTC_2496 diffractaic acid 79.83 µM -0.19753267986135 0.441000238598364 no 1898 0.421705355188525 3023 94870 An apoptosis inducer which activates caspases.
SGTC_180 1486-1293 102.781 µM -0.197584191436466 0.440983778661243 no 1899 0.421685202184894 2815 4140536
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.197670928456675 0.440956063064729 no 1900 0.421651268304907 2741 3256 An antibiotic and ribosome inhibitor.
SGTC_1248 0469-0687 58.6 µM -0.198652226203707 0.440642523328226 no 1901 0.421267398536538 2865 4017482
SGTC_1893 st059353 36.1 µM -0.198937847487284 0.440551269913806 no 1902 0.421155681582081 2807 3112488
SGTC_2361 9034121 116 µM -0.201128729889695 0.439851408157839 no 1903 0.420298958894076 2796 6496917
SGTC_2234 tolnaftate 200 µM -0.201614164682343 0.439696364830141 no 1904 0.420109185405322 2792 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1208 2323-2347 50.3 µM -0.202587477031791 0.439385525864086 no 1905 0.419728739459759 2910 5412760
SGTC_816 0325-0417 81.3 µM -0.20325010129204 0.439173930232093 no 1906 0.41946977740748 2828 68101
SGTC_254 nsc-64875 3.808 µM -0.203744122789743 0.439016185781571 no 1907 0.419276730162112 2913 56993
SGTC_66 0109-0187 42.4 µM -0.204152295042262 0.43888586088899 no 1908 0.419117244616174 2701 759417
SGTC_2534 helenine 20.12 µM -0.205111953322925 0.43857947872209 no 1909 0.418742328788831 2756 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3345 9148410 3.559 µM -0.205361701482915 0.438499749719358 no 1910 0.418644770167989 2901 4903596
SGTC_1176 0848-0131 83.3 µM -0.207065195181795 0.437955997216016 no 1911 0.417979471612148 2877 6769040
SGTC_1129 3453-1384 223 µM -0.209069295185443 0.437316441679975 no 1912 0.417197071955082 3001 1084452
SGTC_923 1900-2434 73.3 µM -0.211603711405129 0.43650788443067 no 1913 0.416208106808331 2759 5910570
SGTC_353 1988-1175 58.3 µM -0.211969378639941 0.436391247074024 no 1914 0.416065461895308 2702 2788357
SGTC_605 1315-0399 119 µM -0.212484090857598 0.436227078017749 no 1915 0.415864694037045 2897 24020461
SGTC_2371 9071574 200 µM -0.212636982119679 0.436178314991103 no 1916 0.41580506173318 2863 45596039
SGTC_1492 4158-0558 28.5 µM -0.212639341010725 0.436177562655725 no 1917 0.41580414170816 2893 3967268
SGTC_2381 9035592 200 µM -0.212666096986441 0.436169029226846 no 1918 0.415793706257604 2833 4749657
SGTC_1611 st001856 99.4 µM -0.212832293682743 0.436116023876064 no 1919 0.415728887024919 2816 647478
SGTC_743 1275-0778 158 µM -0.213087649859072 0.436034585000419 no 1920 0.415629298710768 2904 2849257 YMR203W TOM40
SGTC_708 3448-5400 146 µM -0.213676598162039 0.435846766376235 no 1921 0.415399630915475 2830 3462195
SGTC_3162 9099653 49.47 µM -0.215131279558413 0.4353829231287 no 1922 0.41483248362461 2817 25237511
SGTC_1943 st076331 65.2 µM -0.216006438773058 0.43510391051784 no 1923 0.414491364314454 2879 24208415
SGTC_3271 9137798 49.47 µM -0.216021799051325 0.435099013741198 no 1924 0.414485377764606 2928 6498326
SGTC_907 3448-6986 75.5 µM -0.218120161120351 0.434430160722701 no 1925 0.413667744635128 2949 590582
SGTC_1500 4488-1866 171 µM -0.21820939731761 0.434401720826296 no 1926 0.413632981750388 2944 2900003
SGTC_2030 5175110 200 µM -0.219939696385065 0.433850335587365 no 1927 0.412959059961867 2929 2831986
SGTC_1071 trifluoperazine 6.31 µM -0.220476657144068 0.433679251262085 no 1928 0.412749975006964 2955 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2987 9018338 71.43 µM -0.222113224171541 0.43315789148781 no 1929 0.412112871785089 2750 5055682
SGTC_1164 k060-0068 93.7 µM -0.225003077473959 0.432237557934619 no 1930 0.410988440084214 2805 5963676
SGTC_1688 st021091 57.6 µM -0.22501707551552 0.432233100859313 no 1931 0.410982995267302 2876 3656366
SGTC_50 0929-0078 56.389 µM -0.225143647348627 0.432192799885258 no 1932 0.41093376341201 2838 1377751
SGTC_520 3584-0023 682 µM -0.225227952526875 0.432165957173323 no 1933 0.410900972531817 2860 1340790
SGTC_1185 1319-0113 81.3 µM -0.225474937222974 0.432087319215447 no 1934 0.410804910302538 2910 4672763
SGTC_966 1300-0360 30.2 µM -0.225842974574008 0.431970144050236 no 1935 0.410661775779352 2808 70588
SGTC_1642 st009582 77.7 µM -0.228663407754754 0.431072378281114 no 1936 0.409565268826988 2942 6739311
SGTC_2711 st079103 59.1 µM -0.228845606135309 0.431014395315546 no 1937 0.409494459321516 2865 54693780
SGTC_791 1348-1292 225 µM -0.229004428985272 0.430963852611366 no 1938 0.409432736881282 2875 5437054
SGTC_1184 1269-1718 139 µM -0.229577055038252 0.430781633381286 no 1939 0.409210219053617 2965 5403821
SGTC_1009 4106-0057 9.87 µM -0.230556419199141 0.430470017424944 no 1940 0.408829713937549 2823 2928005
SGTC_3069 9117009 49.47 µM -0.230838686727629 0.430380213032943 no 1941 0.408720062554621 2855 41904981
SGTC_1465 k213-0056 144 µM -0.231407824685805 0.430199150774207 no 1942 0.408498993451523 2803 24048857 YMR208W ERG12
SGTC_2205 7238770 200 µM -0.232293805366745 0.42991731922349 no 1943 0.408154911733625 2950 279867
SGTC_2482 5981709 142.65 µM -0.232839615249897 0.429743714189261 no 1944 0.407942974845371 2879 877755
SGTC_2127 5253358 187.912 µM -0.233473146127842 0.429542224889466 no 1945 0.407697009847077 2775 20612
SGTC_546 peri-Naphthalide 147 µM -0.235922646165595 0.428763354610771 no 1946 0.406746347550652 2899 223824 A penicillin ester.
SGTC_1571 st070080 73.4 µM -0.235988946482227 0.428742276865957 no 1947 0.406720623700819 2975 4315245
SGTC_1035 k081-0041 55.2 µM -0.237981157810403 0.428109021684851 no 1948 0.40594785415526 2927 731709
SGTC_1963 st076565 50.3 µM -0.241188937669097 0.427089768875828 no 1949 0.404704342160528 2855 4914280
SGTC_1315 1237-0019 3.69 µM -0.243868365442666 0.426238769409664 no 1950 0.403666385152045 2938 825140
SGTC_1283 0922-0125 16.4 µM -0.246202557937611 0.425497698049639 no 1951 0.402762717773697 2960 3360884
SGTC_2862 9027634 71.43 µM -0.248339567867839 0.424819459857986 no 1952 0.401935843463212 2808 5012562
SGTC_1366 1683-0113 21.9 µM -0.249185480599437 0.424551047814761 no 1953 0.401608655033614 2845 708623
SGTC_2276 7947513 42.08 µM -0.249485554962321 0.424455841223672 no 1954 0.401492606594411 2924 2105100
SGTC_272 doxorubicin 8.13 µM -0.249876941439154 0.424331670054448 no 1955 0.401341257870876 2824 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2978 9011784 42.97 µM -0.25146534095496 0.423827812060767 no 1956 0.400727177662478 2979 2994934
SGTC_105 0111-0055 734.78 µM -0.252258175304872 0.423576362716364 no 1957 0.400420757089721 2932 5179370
SGTC_1012 4112-3522 18 µM -0.25272570113952 0.423428100338355 no 1958 0.400240092904576 3009 3112398
SGTC_2488 5268135 45.7 µM -0.252994657742645 0.42334281339453 no 1959 0.400136170722613 2993 1270356 YLR208W SEC13
SGTC_1402 3909-7673 35.9 µM -0.254652156143368 0.422817295109709 no 1960 0.399495886000369 2814 5328014
SGTC_1553 gossypol 38.6 µM -0.255032228056346 0.422696810700744 no 1961 0.3993491038277 2826 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_833 3852-0053 558 µM -0.255123056361191 0.422668018812876 no 1962 0.399314028424226 3023 3123681
SGTC_2874 9043904 71.43 µM -0.256568224219955 0.422209967177306 no 1963 0.3987560537087 2925 4463428
SGTC_2555 cholic acid 100 µM -0.257512134660698 0.42191084780363 no 1964 0.398391724494043 3023 6708657 Influences liver metabolism.
SGTC_1950 st077106 7.18 µM -0.257628817589705 0.421873874830717 no 1965 0.398346693525687 2946 13831864
SGTC_854 0422-0053 192 µM -0.257906683563797 0.421785831038444 no 1966 0.398239463291197 2872 3596728
SGTC_1265 0819-1001 68.8 µM -0.258229431213589 0.421683571078771 no 1967 0.398114922581309 2831 3106768
SGTC_2288 7946289 167.31 µM -0.259271374989328 0.421353475772858 no 1968 0.397712931942474 3049 1246052
SGTC_2152 5568786 200 µM -0.260857817770127 0.420850985462727 no 1969 0.397101077683061 2865 5399883
SGTC_1704 st028805 70.8 µM -0.262467624364036 0.420341226675026 no 1970 0.396480471323645 2917 2876101
SGTC_1627 st003713 25.6 µM -0.262525877707184 0.420322782763558 no 1971 0.396458018628041 2939 16195070 YER133W GLC7
SGTC_2318 6029776 164 µM -0.26677018384935 0.418979442915632 no 1972 0.394823056187207 3072 818325
SGTC_464 bw-b 70c 158 µM -0.267723411356514 0.418677871867117 no 1973 0.3944561138895 3008 5353454
SGTC_3315 9136395 68.55 µM -0.267945096641466 0.418607744493605 no 1974 0.394370790159381 3047 16876844
SGTC_2863 9028737 58.44 µM -0.269106198585002 0.418240486685919 no 1975 0.393923980275934 2983 6460917
SGTC_2121 5257820 149.641 µM -0.269480568545432 0.418122088239301 no 1976 0.393779946690343 3042 791256
SGTC_1664 st014217 9.02 µM -0.270473150478835 0.417808209680471 no 1977 0.393398135111392 2907 3982782
SGTC_2946 9065502 71.43 µM -0.27206886582606 0.417303715472687 no 1978 0.392784534162302 2910 16489101
SGTC_285 1486-1325 46 µM -0.272646505083174 0.417121125145671 no 1979 0.392562479927999 3005 22310230
SGTC_896 0964-0007 44.5 µM -0.274414830955252 0.416562273023918 no 1980 0.39188292343033 2967 6756758
SGTC_1451 4152-0210 104 µM -0.276754304556146 0.4158231777241 no 1981 0.390984385378936 3064 659563
SGTC_244 nsc-207895 1.295 µM -0.276769741100217 0.415818301938647 no 1982 0.390978458483456 2841 42640
SGTC_1568 digitonin 820 nM -0.277254244810579 0.415665273229414 no 1983 0.39079244508142 3058 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2041 5107442 45.335 µM -0.279020468905262 0.415107526318198 no 1984 0.390114558208937 3065 793005
SGTC_2836 9010338 19.48 µM -0.279342876752522 0.415005733214446 no 1985 0.38999085223029 2913 2994051
SGTC_1080 nisoldipine 24.4 µM -0.282655187454883 0.413960276426122 no 1986 0.388720585552486 2867 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2462 5162487 171.77 µM -0.283212316898225 0.413784490654636 no 1987 0.388507043600976 2864 2259986
SGTC_876 0720-0963 56.8 µM -0.284488770019407 0.413381808687531 no 1988 0.388017919447236 3089 765861
SGTC_693 4161-2696 114 µM -0.285919058332086 0.412930704655067 no 1989 0.38747005819127 3011 805759
SGTC_2869 9037858 32.47 µM -0.288626556867624 0.412077091675047 no 1990 0.386433585285359 2878 27187042
SGTC_2317 5986382 200 µM -0.2887539609585 0.412036934262694 no 1991 0.38638483289221 2982 877883
SGTC_1096 rimcazole 32.2 µM -0.29143032829836 0.411193564311947 no 1992 0.385361111028647 2896 18528119 A dopamine reuptake inhibitor.
SGTC_642 0335-0876 158 µM -0.293989862906226 0.410387394096241 no 1993 0.384382824751298 2925 6812350
SGTC_2080 5212524 12.4 µM -0.294181393815745 0.410327083264489 no 1994 0.38430964875191 2992 260183
SGTC_3119 9125183 49.47 µM -0.294399235393335 0.41025849009047 no 1995 0.384226425551448 2967 22695334
SGTC_2240 6690706 185.951 µM -0.295524753608784 0.409904134735838 no 1996 0.383796522821344 2842 805876
SGTC_3121 9125696 49.47 µM -0.296579611997388 0.409572092524173 no 1997 0.38339373908436 2942 1235365
SGTC_2933 9026794 32.47 µM -0.296928651965623 0.409462238013115 no 1998 0.383260490506196 2971 17586027
SGTC_512 prima-1 270 µM -0.297555532509583 0.409264955666643 no 1999 0.38302120892471 3075 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1138 3761-0006 1.03 µM -0.298446089625299 0.408984732543962 no 2000 0.382681358214153 2930 12061087
SGTC_2453 5731132 22.18 µM -0.298848536973295 0.408858113521479 no 2001 0.382527807541486 3082 1362040
SGTC_465 cgp-37157 41 µM -0.299586826171408 0.40862585580751 no 2002 0.382246167037016 2995 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_495 decylubiquinone 155 µM -0.299940371361959 0.408514645710988 no 2003 0.382111319650444 3001 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2082 5219693 150 µM -0.301331529699435 0.40807711879496 no 2004 0.381580850172721 2927 2834649
SGTC_3327 9140648 26.9345 µM -0.301861626646153 0.407910430523916 no 2005 0.381378774728013 3078 8029710
SGTC_2744 captopril 92.04 µM -0.302404462338397 0.40773975384407 no 2006 0.381171876721653 3033 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2295 7971645 200 µM -0.302657438077748 0.407660219992074 no 2007 0.381075468395507 2997 2978226 YKL099C UTP11
SGTC_1980 st071811 45.7 µM -0.30447118718472 0.407090101254288 no 2008 0.380384470341036 3082 4974850
SGTC_2628 lathosterol 100 µM -0.304910226887251 0.406952126721871 no 2009 0.380217263252787 3109 6710616
SGTC_274 sirtinol 40.1 µM -0.308851848724009 0.405713934600822 no 2010 0.378717113156887 2980 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2111 5486399 200 µM -0.309627602077438 0.405470355782762 no 2011 0.378422081852765 2958 689674
SGTC_532 1548-0774 215 µM -0.310281650229951 0.405265019620088 no 2012 0.378173392014146 3165 5932993
SGTC_1735 st034310 56.75 µM -0.310423099394939 0.405220615569621 no 2013 0.378119615191836 3132 871153
SGTC_2932 9016711 44.54 µM -0.311055114626333 0.405022226791812 no 2014 0.377879361467509 3091 7117328
SGTC_1545 lovastatin 49.4 µM -0.31205292370272 0.404709065492096 no 2015 0.377500151358922 3020 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_475 α-linolenic acid 10 µM -0.312063708991646 0.404705680873855 no 2016 0.377496053132338 3180 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2517 totarol 10 µM -0.312148131006137 0.404679187969014 no 2017 0.377463974677477 3044 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_877 0771-0151 33.1 µM -0.314514429120202 0.40393678604064 no 2018 0.376565179615171 3048 6166523
SGTC_2217 6934799 96.0675 µM -0.315076900405968 0.403760367187001 no 2019 0.376351633376265 3039 675606
SGTC_3348 9149464 3.537 µM -0.316488911041013 0.403317577052137 no 2020 0.375815720330341 2930 1951442
SGTC_378 3970-0959 8.33 µM -0.31669545956291 0.403252816210757 no 2021 0.37573734717072 3090 6615653
SGTC_2941 9056145 11.23 µM -0.317103509370666 0.403124884829126 no 2022 0.375582531054805 2976 2119517
SGTC_2002 4023503 131 µM -0.317376070982236 0.403039437350979 no 2023 0.375479130988034 3104 4736863 YCR052W RSC6
SGTC_2388 9080168 200 µM -0.317979723158828 0.402850210181797 no 2024 0.375250158926176 2946 15943073
SGTC_3157 9099274 49.47 µM -0.318343942369012 0.402736049194952 no 2025 0.375112027734475 3093 17217662
SGTC_515 4092-1064 102 µM -0.318755723769382 0.402606990287711 no 2026 0.374955877733607 3191 717353
SGTC_741 4582-0002 126 µM -0.319058938189399 0.402511964800423 no 2027 0.374840910089574 2954 2912688
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.319068456093715 0.402508982042437 no 2028 0.374837301433822 2990 4330530
SGTC_1177 0983-0204 23.6 µM -0.319185371574465 0.402472343076059 no 2029 0.374792974531895 3122 766818
SGTC_1048 3161-0300 24.5 µM -0.319298540254009 0.402436879097965 no 2030 0.374750069753762 2966 2165101
SGTC_2982 9019404 25.97 µM -0.320236968082661 0.402142832368313 no 2031 0.374394350545827 2980 22333232
SGTC_1014 4130-3005 69.3 µM -0.320316980597409 0.402117763827489 no 2032 0.374364026049267 2960 743608
SGTC_834 0312-0008 75.7 µM -0.320784589807469 0.401971266294393 no 2033 0.37418681914837 2964 6385573 YIL048W NEO1
SGTC_1613 st002381 52.1 µM -0.321600820009265 0.401715582120175 no 2034 0.373877561268887 2998 551167
SGTC_663 1486-0733 13.9 µM -0.321806670816592 0.401651105976701 no 2035 0.373799580169215 2974 722445 YPR165W RHO1
SGTC_154 3389-1638 511.116 µM -0.322309856434399 0.401493510542355 no 2036 0.373608983442351 3047 5238686
SGTC_2440 5628896 157.78 µM -0.322339872225888 0.401484110239828 no 2037 0.373597615032607 2986 5522048
SGTC_1271 0832-2808 169 µM -0.322343126293849 0.401483091138917 no 2038 0.373596382568703 3126 3663794
SGTC_3239 9133757 49.47 µM -0.324173546437625 0.400909951106259 no 2039 0.372903324234481 2965 17036923
SGTC_3307 9126885 69.2785 µM -0.324978777095428 0.40065788523222 no 2040 0.372598567042394 2972 24824909
SGTC_1854 st056233 32.9 µM -0.325598633536288 0.400463876258823 no 2041 0.372364023093464 3074 5393174
SGTC_2707 st078556 66.6 µM -0.32672733749828 0.400110666109602 no 2042 0.371937060848522 3047 17250899
SGTC_2963 9082507 9 µM -0.326864844480304 0.400067641039661 no 2043 0.371885055929134 3141 16459611
SGTC_1054 3429-0080 167 µM -0.327698037063741 0.399806966280107 no 2044 0.371569993855591 3167 1162877
SGTC_1755 st041960 45.185 µM -0.328093432017399 0.399683277618772 no 2045 0.371420509939458 3094 2257073
SGTC_2709 st078560 56 µM -0.329206771318867 0.399335053521146 no 2046 0.370999702586954 3153 17250903
SGTC_208 k072-0098 12.366 µM -0.330416017228241 0.398956923012749 no 2047 0.370542820261813 2991 5948901
SGTC_1121 fusaric acid 630.51 nM -0.331298596290341 0.398681000869436 no 2048 0.37020947574748 3000 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_74 000s-0487 160.283 µM -0.331314203534023 0.398676122006398 no 2049 0.37020358186676 2991 677548
SGTC_3023 9089636 49.47 µM -0.331866341117134 0.39850353262408 no 2050 0.369995093621682 3079 17249241
SGTC_3009 9080819 71.4286 µM -0.333296052443906 0.398056720041285 no 2051 0.369455409451563 3063 17027216
SGTC_2643 anethole 100 µM -0.334937156171199 0.397544008009607 no 2052 0.368836246360299 3051 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2123 5259487 200 µM -0.335065611230241 0.397503883660755 no 2053 0.368787796589351 3116 2173474
SGTC_383 2324-0395 7.37 µM -0.335904788443849 0.397241784141214 no 2054 0.368471333002571 3128 3146421
SGTC_2875 9039966 71.43 µM -0.335956881002761 0.397225515643964 no 2055 0.36845169122475 3067 6463691
SGTC_2755 lomerizine 42.69 µM -0.336215401825664 0.39714478228123 no 2056 0.3683542196533 3033 3949 A calcium channel blocker.
SGTC_970 1315-0089 19.5 µM -0.337419330110468 0.396768866110519 no 2057 0.36790040743145 3036 6811083 YLR033W RSC58
SGTC_1078 idebenone 36.1 µM -0.338166337235271 0.396535667807861 no 2058 0.367618921021279 3072 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2218 6965428 192.983 µM -0.340552836176017 0.395790906517274 no 2059 0.366720120172312 3084 675684
SGTC_570 0987-0065 62.6 µM -0.340779470602756 0.395720199818557 no 2060 0.366634803233396 2957 3104428
SGTC_1808 st050063 61.5 µM -0.341940129735297 0.395358144611383 no 2061 0.366197974370174 3164 4011993
SGTC_3215 9129942 49.47 µM -0.34221526570527 0.395272332116267 no 2062 0.366094448834878 3141 17682944
SGTC_1082 camptothecin 424.86 nM -0.342691073668541 0.395123943774154 no 2063 0.365915439365485 2837 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3091 9116372 49.47 µM -0.342761617675463 0.395101944788574 no 2064 0.365888901634812 3169 17169793
SGTC_2855 9016525 58.44 µM -0.343125585085162 0.394988447707066 no 2065 0.365751992064811 2970 43811474
SGTC_3008 9078912 71.4286 µM -0.353026627015343 0.39190442370384 no 2066 0.362034239314579 3055 16648731
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.354918607332391 0.391315866221593 no 2067 0.361325284087045 3155 6708760
SGTC_3200 9114385 49.47 µM -0.355589604037348 0.391107192165654 no 2068 0.361073965115098 3162 17018030 YLR208W SEC13
SGTC_1147 3809-1045 12.3 µM -0.356795648490228 0.390732201815861 no 2069 0.360622397076193 3046 325925
SGTC_3088 9117578 49.47 µM -0.356934282387898 0.390689103462499 no 2070 0.360570502110096 3112 678341
SGTC_901 1112-0062 60.1 µM -0.356990827273246 0.390671525236363 no 2071 0.360549336343621 3041 1908457
SGTC_80 0159-0065 512.242 µM -0.358400338562819 0.39023341981748 no 2072 0.360021869161335 3108 1548079
SGTC_1971 st069429 63.5 µM -0.360145429558982 0.389691202380522 no 2073 0.359369190551199 3164 1246522 YGL099W LSG1
SGTC_777 1315-0167 517 µM -0.363521667228393 0.388642781305302 no 2074 0.358107615135827 3111 4221767
SGTC_466 geldanamycin 89.2 µM -0.364101307349115 0.388462867325001 no 2075 0.357891180306045 3081 5288382 HSP90 inhibitor.
SGTC_551 k048-0028 34.9 µM -0.364397675218217 0.388370887208349 no 2076 0.357780535613258 3181 6836383
SGTC_1530 rhein 70.4 µM -0.364796596320009 0.388247088768013 no 2077 0.357631623009364 3035 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1518 st038567 90.8 µM -0.365551355775032 0.388012892963382 no 2078 0.357349939389513 3108 77966
SGTC_3245 9134821 49.47 µM -0.365834734834294 0.387924973225096 no 2079 0.357244199606827 3054 17014901
SGTC_2521 angolensin 13.4 µM -0.367255578117456 0.387484236349872 no 2080 0.356714192956729 3199 821428 A flavenoid.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.368342932462803 0.387147043585485 no 2081 0.35630877193102 3090 229346 A bile salt which induces apoptosis.
SGTC_2667 digitoxin 100 µM -0.370460398355408 0.386490653808631 no 2082 0.355519739180191 3139 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2792 7535235 81.82 µM -0.370894095212707 0.386356252827509 no 2083 0.355358206665145 3110 1281891
SGTC_1092 toremifene 6.32 µM -0.372512855882155 0.385854725679308 no 2084 0.354755521014096 3039 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3312 9133330 71.43 µM -0.372551247567808 0.385842833414975 no 2085 0.354741231695331 3206 17617324
SGTC_2047 4141938 200 µM -0.373696866858103 0.38548801413335 no 2086 0.354314928306413 3098 3807862
SGTC_223 busulfan 5 mM -0.376579179353924 0.384595733554336 no 2087 0.353243181525343 3151 2478 A DNA alkylator.
SGTC_945 3381-0768 11.3 µM -0.377965765917104 0.384166703833703 no 2088 0.352728012817653 3215 1126236 YIL048W NEO1
SGTC_2916 7875993 68.79 µM -0.378418846568805 0.384026544929052 no 2089 0.352559734897715 3202 1299250
SGTC_1228 0124-0032 52.5 µM -0.379541622307286 0.383679283602779 no 2090 0.352142851046406 3144 X1228
SGTC_2898 9056270 58.44 µM -0.380066688288424 0.383516918907828 no 2091 0.351947956272519 3139 19154699
SGTC_1202 1988-0068 29.6 µM -0.380741730422868 0.383308207556934 no 2092 0.351697450270691 3077 2850480
SGTC_1847 st056231 15 µM -0.381762605030049 0.382992635133488 no 2093 0.351318729258329 3058 5393180
SGTC_3048 9093155 49.47 µM -0.382454575180532 0.38277877768512 no 2094 0.351062108131631 3194 25236002
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.385100817885788 0.381961270946139 no 2095 0.350081361036081 3105 688664
SGTC_490 phenamil 164 µM -0.385459894912062 0.381850381329926 no 2096 0.349948357208176 3135 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_736 0958-0254 92.6 µM -0.386452599149997 0.381543866400041 no 2097 0.349580750700957 3191 6812352
SGTC_133 0724-0033 378.92 µM -0.387990870932725 0.381069044648124 no 2098 0.349011394703436 2991 280309
SGTC_287 k060-0039 29.6 µM -0.388593709704998 0.380883013854852 no 2099 0.348788360355202 3221 5861974
SGTC_2187 6125751 200 µM -0.388740310042668 0.380837778427941 no 2100 0.34873413001487 3120 874498
SGTC_2398 5228213 48.84 µM -0.390101241746287 0.380417923197952 no 2101 0.348230842326667 3285 80771 YMR134W ERG29
SGTC_1721 st082152 9.2685 µM -0.390951091620186 0.38015581104 no 2102 0.347916693823917 3066 5296051
SGTC_3014 9081533 49.47 µM -0.39131334275586 0.38004410164295 no 2103 0.347782818764478 3216 21367265
SGTC_899 1083-0020 478 µM -0.391741136577796 0.379912193370455 no 2104 0.347624745910844 3253 767123
SGTC_2892 9047358 58.44 µM -0.393433406199078 0.3793905268297 no 2105 0.346999700152039 3116 6466771
SGTC_3350 9150499 3.57 µM -0.393513025167968 0.379365988532599 no 2106 0.346970302839852 3057 4910996 YPR165W RHO1
SGTC_2854 9024559 71.43 µM -0.394012815804666 0.379211965851076 no 2107 0.346785788695564 3179 3163529
SGTC_1651 st011928 86.1 µM -0.394160932944563 0.379166323621523 no 2108 0.346731113361297 3190 720198
SGTC_920 mycophenolic acid 780.421 nM -0.395136656215123 0.378865697061395 no 2109 0.346371018820708 3105 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_354 2783-3500 4.88 µM -0.395622603836917 0.378716000821539 no 2110 0.346191729686681 3117 6740761
SGTC_3285 9112818 20.8695 µM -0.395721345425942 0.378685585683172 no 2111 0.346155303441496 3097 17017947 YPR165W RHO1
SGTC_2029 5175081 200 µM -0.396287690663312 0.37851115021694 no 2112 0.345946403472814 3087 1380876
SGTC_1120 ficusin 1.78878 µM -0.396783668239886 0.378358408459138 no 2113 0.345763497556378 3230 6199 A DNA cross-linker.
SGTC_830 4076-0286 57.8 µM -0.396939857864206 0.378310312077683 no 2114 0.345705905615302 3107 6866659
SGTC_2690 usnic acid 100 µM -0.399260709279251 0.37759586130491 no 2115 0.344850557321959 3346 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_161 4065-0411 162.148 µM -0.400569505589899 0.377193145952504 no 2116 0.3443685503844 3205 1906281 YLR208W SEC13
SGTC_94 0334-0113 514.748 µM -0.400886239574144 0.377095707264132 no 2117 0.34425194070263 3135 6795178
SGTC_2140 5586273 200 µM -0.401791455115648 0.376817273787975 no 2118 0.343918755637847 3186 854421
SGTC_2645 abamectin 100 µM -0.402525997215523 0.376591384492229 no 2119 0.343648479832437 3202 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1659 st012954 42.1 µM -0.405483422237611 0.375682333659241 no 2120 0.34256110082108 3220 24207262
SGTC_308 4092-1169 104 µM -0.405638403975528 0.375634714476232 no 2121 0.34250415337016 3109 2268590 YDL196W YDL196W
SGTC_6 0844-0013 19.835 µM -0.407114308085954 0.375181328011544 no 2122 0.341962017552105 3228 1584900
SGTC_2565 isoliquiritigenin 100 µM -0.40743065666699 0.375084170559095 no 2123 0.341845857298301 3220 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_692 k241-0027 77.8 µM -0.408068457794065 0.374888312219519 no 2124 0.341611708190873 3281 3600480
SGTC_2309 7664088 163.95 µM -0.408560244881816 0.374737314439798 no 2125 0.341431205257683 3301 704922
SGTC_683 panaxydol 45 µM -0.410579822497444 0.374117427077402 no 2126 0.34069033080122 3133 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1814 st052110 31.539 µM -0.410764214429343 0.374060846166402 no 2127 0.340622717869043 3255 674163
SGTC_1401 3807-4679 7.6 µM -0.411589483156948 0.373807644613844 no 2128 0.340320170666594 3179 3291456
SGTC_2198 6589944 200 µM -0.413702143295934 0.373159705511959 no 2129 0.33954612862401 3183 5290268
SGTC_716 1683-5115 658 µM -0.416107843334574 0.372422329638272 no 2130 0.338665545431292 3200 723597
SGTC_156 3474-0145 5.642 µM -0.416663175286694 0.372252180050351 no 2131 0.338462396561933 3258 2265471
SGTC_1746 st038117 42 µM -0.418425815509947 0.371712285500018 no 2132 0.337817907566337 3210 2898218
SGTC_3092 9117248 49.47 µM -0.419183459962014 0.371480297371322 no 2133 0.337541029559741 3197 17141857
SGTC_100 0086-0128 49.5915 µM -0.419552826230884 0.371367215607592 no 2134 0.337406078068099 3189 93297
SGTC_1486 3970-0793 4.53 µM -0.421424118603836 0.370794488816521 no 2135 0.336722705192417 3228 2844330
SGTC_648 0375-0473 33.3 µM -0.422235777824615 0.370546161708546 no 2136 0.336426464650816 3150 1713139
SGTC_2912 7964298 10.93 µM -0.422273608703279 0.37053458866721 no 2137 0.336412659557309 3231 2975850
SGTC_1905 st060207 84.5 µM -0.422466530923859 0.370475572647216 no 2138 0.336342262579521 3108 1948547
SGTC_3196 9111891 49.47 µM -0.422514262632158 0.370460971712667 no 2139 0.336324846248678 3184 18891510
SGTC_2226 7298446 200 µM -0.422608746950364 0.370432069896077 no 2140 0.336290371875911 3242 3283010
SGTC_643 k048-0106 28.4 µM -0.424412032649027 0.369880603024773 no 2141 0.335632673455575 3243 6763920
SGTC_1508 1080-0625 72.9 µM -0.425141758244313 0.369657519944524 no 2142 0.33536666919928 3193 767111
SGTC_936 3005-4620 401 µM -0.42631574839587 0.369298713638562 no 2143 0.334938891979457 3338 777207
SGTC_176 1486-1328 72.834 µM -0.429634660131684 0.368284972181372 no 2144 0.333730710109309 3222 22310231
SGTC_1994 st072947 40.9 µM -0.430595826162732 0.367991560644359 no 2145 0.333381138288193 3271 5286565 YDL195W SEC31
SGTC_1109 tnp00067 928.257 nM -0.432378450205887 0.367447589656398 no 2146 0.332733188942463 3195 676295
SGTC_2018 5133068 143 µM -0.43242364800774 0.367433800916002 no 2147 0.332716766898323 3131 785362
SGTC_672 1441-0018 53.7 µM -0.433000121240003 0.367257948074998 no 2148 0.332507340873159 3136 251141
SGTC_3250 9135583 49.47 µM -0.433015958554311 0.367253117303774 no 2149 0.332501588098394 3279 7699353
SGTC_803 4488-1585 147 µM -0.436604553654677 0.366159050509912 no 2150 0.331199079831962 3268 747204
SGTC_2379 9035213 200 µM -0.437684478820214 0.365830022578003 no 2151 0.330807511205955 3302 646551
SGTC_2255 7941087 197.44 µM -0.438157040461546 0.365686075121607 no 2152 0.330636223889505 3303 935561
SGTC_3318 9139014 38.6185 µM -0.439517229662773 0.365271852196128 no 2153 0.330143400202808 3176 16643984
SGTC_1851 st056236 18.9 µM -0.44051396658566 0.364968412322755 no 2154 0.329782449483811 3338 5393171
SGTC_583 1488-1091 88.9 µM -0.441765797445573 0.3645874331573 no 2155 0.329329345491348 3275 4303273
SGTC_2486 5283202 22.39 µM -0.445518442342209 0.363446164817267 no 2156 0.327972567550932 3192 1377751
SGTC_2686 alizarin 95.37 µM -0.445540546627038 0.363439445957553 no 2157 0.327964582392083 3200 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_448 monastrol 171 µM -0.446123011456327 0.363262414003869 no 2158 0.327754195690685 3229 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_422 cantharidin 155 µM -0.448721567451046 0.362472975890411 no 2159 0.326816262170685 3136 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1622 st003707 19.4 µM -0.448957214589255 0.3624014154309 no 2160 0.326731260698639 3285 10140899
SGTC_1499 4480-0877 67.3 µM -0.448999951966554 0.3623884376157 no 2161 0.326715845646148 3239 2861909
SGTC_2977 9011197 71.43 µM -0.449658806004417 0.362188387193819 no 2162 0.326478239364138 3354 2704722
SGTC_2070 5230947 200 µM -0.451496115074973 0.361630716838322 no 2163 0.325816012197409 3309 2835538
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.451731643345666 0.361559249195362 no 2164 0.325731159662309 3187 6857784
SGTC_3015 9080845 49.47 µM -0.45185804321269 0.361520896977394 no 2165 0.325685625967109 3331 5296973
SGTC_42 0133-0086 60.653 µM -0.452334191061694 0.361376436803653 no 2166 0.325514124053799 3155 162923 Model of phenazepam hydroxylation.
SGTC_2582 agaric acid 100 µM -0.453223643193536 0.361106635737965 no 2167 0.325193854576596 3290 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2570 licareol 100 µM -0.454013209099221 0.360867191435102 no 2168 0.324909659777354 3232 443158
SGTC_1805 st050013 60.3 µM -0.454999622399126 0.360568127669929 no 2169 0.324554755245595 3221 4037144
SGTC_1633 st005664 67.9 µM -0.455769647629688 0.36033472834291 no 2170 0.324277816278757 3159 2063822
SGTC_1111 tnp00062 510.699 nM -0.457368868485457 0.359850161133419 no 2171 0.323702968390739 3350 676306
SGTC_1638 st008370 60.6 µM -0.461061608217613 0.358732114783626 no 2172 0.322377202453506 3276 24207134
SGTC_77 0828-0286 12.516 µM -0.461492666273178 0.35860168250452 no 2173 0.322222590887974 3316 745345
SGTC_2415 st077333 57.7 µM -0.462202672008572 0.358386880425479 no 2174 0.321967993643387 3420 2766255
SGTC_306 1672-3436 11.6 µM -0.463186070067651 0.35808944142175 no 2175 0.321615500075159 3311 6797378
SGTC_347 4534-1311 26.2 µM -0.466837401982857 0.356985812702962 no 2176 0.320308107068165 3255 2862016
SGTC_2658 polymyxin b sulfate 77.05 µM -0.470149723848754 0.355985684959392 no 2177 0.319124025514027 3260 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1347 1493-0251 600 nM -0.471388337910689 0.35561194984592 no 2178 0.318681721253121 3334 3986378
SGTC_2754 granisetron 64.02 µM -0.471667439786975 0.355527753758402 no 2179 0.3185820906824 3362 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.471938467938153 0.35544600000132 no 2180 0.3184853547282 3205 15053
SGTC_415 dibenzyl ketone 100 µM -0.472175160222452 0.355374608859948 no 2181 0.318400884126399 3285 7593
SGTC_724 3910-0327 137 µM -0.473536626615547 0.354964061898127 no 2182 0.317915188236577 3298 2885483
SGTC_1345 1488-0192 31.4 µM -0.474174107353597 0.354771888929077 no 2183 0.317687877932801 3345 658348
SGTC_603 3794-0023 45.9 µM -0.474415093679297 0.354699251559375 no 2184 0.317601965893593 3319 3802260
SGTC_2446 5162541 200 µM -0.474776081249107 0.354590453661663 no 2185 0.317473291581191 3195 1549321
SGTC_282 k297-0036 65.7 µM -0.475311909063645 0.354428982606225 no 2186 0.317282335983768 3335 5061378
SGTC_111 0083-0039 52.457 µM -0.476472988048702 0.354079182672136 no 2187 0.316868723451433 3232 759313
SGTC_56 0957-0365 83.25 µM -0.476505544238946 0.354069376194916 no 2188 0.31685712921653 3322 6752360
SGTC_2995 9067767 71.4286 µM -0.47680376552077 0.35397955138665 no 2189 0.316750932052827 3252 11673567
SGTC_1004 4084-0029 199 µM -0.478445187573613 0.353485297563533 no 2190 0.316166689013004 3351 716894 YLR208W SEC13
SGTC_3160 9100216 49.47 µM -0.479186328186104 0.353262211224824 no 2191 0.315903039781299 3302 17191039
SGTC_3233 9132340 49.47 µM -0.481949350176684 0.352430975201606 no 2192 0.314920963699255 3252 17682950
SGTC_1770 st043884 66.3 µM -0.482447179826896 0.352281281366729 no 2193 0.314744156153988 3292 670149
SGTC_446 go6976 132 µM -0.483721711333766 0.351898143135772 no 2194 0.314291691309401 3333 3501 A protein kinase C inhibitor.
SGTC_194 1486-1323 56.904 µM -0.484821580683759 0.351567631099294 no 2195 0.313901456515488 3287 5178754
SGTC_3198 9112019 49.47 µM -0.485740004375916 0.351291729628033 no 2196 0.313575758200562 3319 45595555
SGTC_2465 5809242 33.21 µM -0.486383982145024 0.351098320520243 no 2197 0.313347472588738 3304 2731748
SGTC_2603 homopterocarpin 100 µM -0.489293239243211 0.350225049869715 no 2198 0.312317053399907 3335 101795 A weak amylase inhibitor.
SGTC_1796 st049173 110.4 µM -0.489377391440655 0.350199801688712 no 2199 0.312287269619167 3352 94134
SGTC_1583 clindamycin 39.6 µM -0.490224559917886 0.349945662657129 no 2200 0.311987501712261 3245 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1279 0874-0590 65.2 µM -0.490791891322579 0.349775508508443 no 2201 0.311786822852467 3306 3523074
SGTC_1588 farnesol 29.9 µM -0.490893932327399 0.349744907549907 no 2202 0.311750734404076 3301 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_987 1497-1013 404 µM -0.490965854125806 0.349723339591683 no 2203 0.311725299185237 3352 1676435
SGTC_2717 st081029 62.2815 µM -0.492389142618156 0.34929662270615 no 2204 0.311222136607303 3356 5292846
SGTC_3039 9090270 49.47 µM -0.493160844836454 0.34906533782831 no 2205 0.310949470881097 3393 17173750
SGTC_761 k216-0224 480 µM -0.49430075062059 0.34872380218447 no 2206 0.310546897550526 3428 1340404
SGTC_1020 4335-0961 93.3 µM -0.494450424055165 0.348678966511141 no 2207 0.310494055162438 3194 669075
SGTC_1747 st037496 66.6 µM -0.494597267208865 0.348634980721119 no 2208 0.310442215808742 3253 723305
SGTC_882 0843-0131 351 µM -0.496145343002469 0.348171389869063 no 2209 0.309895935056568 3395 5425421
SGTC_1987 st072290 61.9 µM -0.497050940632402 0.347900302306308 no 2210 0.309576564619387 3297 54697379
SGTC_2833 9001315 45.46 µM -0.498787691842515 0.347380629319448 no 2211 0.308964479671954 3213 2989378
SGTC_757 1066-0008 322 µM -0.501004421345864 0.346717753259134 no 2212 0.308184005637574 3369 6842497
SGTC_2278 7948257 134.34 µM -0.502606641868765 0.346238927731202 no 2213 0.30762042931737 3376 1247028
SGTC_1960 st011366 51.8 µM -0.503293096868945 0.346033854961003 no 2214 0.307379109561963 3342 3972846
SGTC_789 1309-1135 70.6 µM -0.503992035902439 0.345825099074433 no 2215 0.30713348675527 3373 3092424
SGTC_3313 9133968 57.047 µM -0.504094569290124 0.345794478815145 no 2216 0.30709746150388 3356 1494643
SGTC_1338 1486-1223 76 µM -0.504130371969943 0.345783787049227 no 2217 0.307084882620055 3332 3444526
SGTC_1886 st057356 49.9 µM -0.505940327887312 0.345243439752269 no 2218 0.306449270322964 3257 24207747
SGTC_1272 0839-0021 27 µM -0.506227466002333 0.345157746006046 no 2219 0.306348487861622 3348 5027250
SGTC_1311 1190-0148 100 µM -0.506877184015945 0.344963872914629 no 2220 0.306120497747641 3413 1961333
SGTC_451 chloral hydrate 100 µM -0.508519709856471 0.344473931765957 no 2221 0.30554446010549 3374 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3278 9139605 49.47 µM -0.50958115198479 0.344157457966482 no 2222 0.305172465622948 3435 7958859
SGTC_2107 5363541 170.161 µM -0.509723331944234 0.344115074646787 no 2223 0.305122652306962 3380 244052
SGTC_3010 9080089 71.4286 µM -0.51025272847001 0.343957280724854 no 2224 0.304937207872985 3369 17027233
SGTC_2727 riluzole 51.77 µM -0.510657065947037 0.343836780674484 no 2225 0.304795604609366 3352 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1944 st076371 56.9 µM -0.511561871326732 0.343567189404414 no 2226 0.304478838122593 3266 24208455
SGTC_2798 7813637 45.45 µM -0.511722129987596 0.343519447827123 no 2227 0.304422747881722 3395 956368
SGTC_1759 st043059 70 µM -0.512223822976542 0.343370007992717 no 2228 0.304247185987997 3263 669426
SGTC_1266 0828-0227 32.9 µM -0.513302175149509 0.343048880959747 no 2229 0.30386998133977 3330 3913820
SGTC_820 1582-0060 59.9 µM -0.513899274267965 0.342871117032314 no 2230 0.303661207464274 3294 3848840
SGTC_2174 5790901 200 µM -0.514340218503542 0.342739864703187 no 2231 0.303507073777536 3374 786020
SGTC_338 4055-0136 114 µM -0.515388428143867 0.342427928774524 no 2232 0.303140808570353 3309 2900563
SGTC_1156 4092-0367 4.88 µM -0.516086866974139 0.342220140519401 no 2233 0.302896870009647 3332 1357585
SGTC_217 ketoconazole 989 nM -0.516107826689952 0.34221390566068 no 2234 0.302889550923097 3347 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_401 neomycin 50 µM -0.516389023682012 0.34213026252637 no 2235 0.302791365210762 3341 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2788 5282734 71.43 µM -0.516679822094953 0.342043771558952 no 2236 0.302689841959647 3430 743706
SGTC_1324 1418-0026 34.4 µM -0.517605342488427 0.341768553043268 no 2237 0.302366826759207 3370 1372513
SGTC_2458 5808907 16.39 µM -0.517811497282676 0.341707261013063 no 2238 0.302294897884715 3454 2731747
SGTC_2546 rhodinyl acetate 100 µM -0.521326852657319 0.340662751606426 no 2239 0.301069548948202 3420 6708682
SGTC_2116 5511452 16.8835 µM -0.521423595800645 0.340634023762909 no 2240 0.301035858819969 3409 870744
SGTC_190 3970-0790 3.722 µM -0.522419750586144 0.340338269730897 no 2241 0.300689053712272 3386 2832352
SGTC_1635 st007035 42.4 µM -0.522677482362889 0.340261766264606 no 2242 0.300599355363943 3399 3716403
SGTC_1974 st069448 26.9 µM -0.524474188156709 0.339728626332302 no 2243 0.299974384085518 3403 6323587 YNR016C ACC1
SGTC_1446 4239-0190 62 µM -0.524613524844268 0.339687294068568 no 2244 0.299925941390445 3298 1340085
SGTC_2249 haloperidol 116.36 µM -0.528240231663145 0.338612161958496 no 2245 0.298666304539816 3415 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_319 1348-1596 45.5 µM -0.528424741000449 0.338557499476454 no 2246 0.298602284642627 3466 5380505
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.529956992806471 0.338103688157986 no 2247 0.298070874770574 3420 61125 An anti-inflammatory.
SGTC_1063 disulfiram 1.84 µM -0.533056008623816 0.337186563217942 no 2248 0.296997404995615 3383 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2320 7373003 200 µM -0.533104967335513 0.33717208208512 no 2249 0.296980460358526 3394 5415828
SGTC_824 1304-0008 100 µM -0.533219051647584 0.337138338871957 no 2250 0.29694097743128 3335 768245
SGTC_1737 st035557 69.7 µM -0.533672969600557 0.3370040945647 no 2251 0.296783906797807 3349 5716916
SGTC_2344 7990960 76.95 µM -0.533822590079181 0.336959849491268 no 2252 0.296732141496531 3341 140813
SGTC_225 nsc-122657 1.016 µM -0.534239563460327 0.336836555963314 no 2253 0.296587899957075 3389 275685
SGTC_1607 st000305 50.6 µM -0.536277498385811 0.336234217934543 no 2254 0.295883389778936 3431 5457690
SGTC_746 1095-0025 46.6 µM -0.538054751949501 0.335709270556242 no 2255 0.295269624753527 3460 6749286
SGTC_1707 st032323 6.317 µM -0.538652819741704 0.335532691282763 no 2256 0.295063217088587 3388 3132057 YMR211W DML1
SGTC_924 2046-0044 21.3 µM -0.539202264092706 0.335370500068115 no 2257 0.294873649144017 3414 3623589
SGTC_1294 1000-1494 117 µM -0.539466756503035 0.335292435135781 no 2258 0.294782414639529 3370 712797 YDL207W GLE1
SGTC_2060 5238662 140 µM -0.540050494575072 0.335120170022658 no 2259 0.294581105014623 3377 790130
SGTC_88 0180-0332 8.668 µM -0.541318989093157 0.334745948162985 no 2260 0.294143867096599 3364 3101745
SGTC_1346 1488-2224 62.4 µM -0.54156121507893 0.33467450709118 no 2261 0.2940604082305 3445 3722427
SGTC_1215 3852-0577 11.2 µM -0.543857345236068 0.333997594063304 no 2262 0.293269821730626 3475 2884876
SGTC_904 1141-0088 396 µM -0.546858353123379 0.333113692695824 no 2263 0.292238024871243 3395 1378119
SGTC_2947 9072639 7.68 µM -0.547369400702278 0.332963263544544 no 2264 0.292062486552888 3435 16488146
SGTC_2291 7917025 104.35 µM -0.548541354940904 0.332618395072345 no 2265 0.291660120681497 3324 2964612
SGTC_811 0416-0114 265 µM -0.549518384344541 0.332330994933804 no 2266 0.291324875788858 3445 6612453
SGTC_2073 5212005 126 µM -0.549626133425471 0.332299305807666 no 2267 0.291287915212828 3345 691789
SGTC_1452 4194-0072 190 µM -0.549971907438739 0.3321976213784 no 2268 0.29116932103403 3481 1343545
SGTC_594 1487-1584 10.8 µM -0.552380546535463 0.331489637397319 no 2269 0.290343827972019 3345 5013332
SGTC_3173 9105693 49.47 µM -0.553111059083891 0.331275032790553 no 2270 0.290093682184244 3521 17096658
SGTC_2616 abietic acid 100 µM -0.554220118790589 0.33094932729736 no 2271 0.289714105568192 3473 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1108 betulinic acid 729.144 nM -0.554996222030584 0.330721479564319 no 2272 0.289448622280902 3392 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_949 1165-0505 146 µM -0.559117501389897 0.32951261017797 no 2273 0.288040765626818 3390 6244267
SGTC_1442 4112-3290 3 µM -0.560687649424974 0.329052515784014 no 2274 0.287505244076168 3435 704353
SGTC_925 2064-1272 59.6 µM -0.562468999277741 0.328530847162145 no 2275 0.286898259749819 3373 6815817
SGTC_1848 st056003 16.4 µM -0.563773316982786 0.328149089259454 no 2276 0.286454206693872 3495 146492
SGTC_2771 fluoxetine 41.05 µM -0.564560552568241 0.327918761794986 no 2277 0.286186351414085 3502 3386 A selective serotonin reuptake inhibitor.
SGTC_2181 6316240 54.2555 µM -0.564901582497022 0.327819004399599 no 2278 0.286070353626858 3441 12779990
SGTC_2831 7999036 19.48 µM -0.564964711845776 0.327800539275675 no 2279 0.286048883285466 3495 2988270
SGTC_1318 1280-3875 124 µM -0.565092345908874 0.327763208024124 no 2280 0.286005477178939 3447 373245
SGTC_3068 9116768 49.47 µM -0.565216475704694 0.327726903374815 no 2281 0.285963265815063 3458 41904888
SGTC_2215 7188065 200 µM -0.565968264985719 0.327507059900131 no 2282 0.285707676949559 3486 940217
SGTC_342 k048-0088 23.3 µM -0.567364728348257 0.327098855070076 no 2283 0.285233204240022 3389 6820570
SGTC_2537 larixol 68.93 µM -0.567743273334477 0.326988236929969 no 2284 0.285104651710537 3492 6708759
SGTC_1180 1193-0155 285 µM -0.572251626263816 0.325671980101751 no 2285 0.283575758271397 3478 2921347
SGTC_1525 8-methoxypsoralen 92.5 µM -0.577034710973524 0.324277885268152 no 2286 0.281958003704689 3546 4114 Related to psoralen; DNA damaging agent.
SGTC_186 3455-3465 67.277 µM -0.579297550265821 0.323619205942634 no 2287 0.281194209096755 3453 755278
SGTC_584 0986-0246 15.4 µM -0.579325905619086 0.323610955614191 no 2288 0.281184644425165 3539 53315 YDR232W HEM1
SGTC_1231 0242-0792 125 µM -0.579618628824405 0.323525789372035 no 2289 0.281085913829887 3451 3707635
SGTC_124 0136-0217 7.121 µM -0.580196824893566 0.323357593500043 no 2290 0.280890947280379 3589 3976905
SGTC_3299 9121982 43.1275 µM -0.581308132232144 0.323034418195499 no 2291 0.280516400355277 3440 17594604 YPL160W CDC60
SGTC_502 l-744,832 89.3 µM -0.583405262544083 0.322424923186028 no 2292 0.279810257998792 3479 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2086 5274770 176.623 µM -0.583763676366906 0.322320804029416 no 2293 0.279689659806454 3454 689278
SGTC_1485 3909-9022 254 µM -0.584032277941511 0.322242784452263 no 2294 0.279599297954445 3515 714516
SGTC_3107 9121808 49.47 µM -0.585129790056892 0.321924076091928 no 2295 0.279230224707679 3469 662681
SGTC_1334 1486-0610 236 µM -0.585340280808311 0.321862966292206 no 2296 0.279159467588342 3501 3742339
SGTC_862 0452-0056 10.2 µM -0.586133075043781 0.321632845055004 no 2297 0.278893045610799 3466 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2998 9066762 71.4286 µM -0.586399905122432 0.321555408731595 no 2298 0.278803404027431 3559 4945196
SGTC_1646 st011709 75.6 µM -0.587331800617603 0.321285025694637 no 2299 0.278490443723751 3493 5757843
SGTC_3333 9141820 12.094 µM -0.592020216724661 0.319926153142946 no 2300 0.276918525330212 3432 1939433
SGTC_2512 diallyl trisulfide 49.23 µM -0.592078773838822 0.319909196392334 no 2301 0.276898919975027 3505 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2666 tannic acid 100 µM -0.592459630944619 0.31979891839673 no 2302 0.276771422786549 3526 16134267 A thiamine antagonist.
SGTC_2720 fluspirilene 36.88 µM -0.592958370695587 0.319654531311474 no 2303 0.276604506251259 3486 3396 An atypical antipsychotic.
SGTC_3026 9090633 49.47 µM -0.592984519451351 0.319646961899455 no 2304 0.276595756235441 3459 25236842
SGTC_167 3672-0051 66.205 µM -0.594096052332559 0.319325270383349 no 2305 0.276223935548518 3488 3237971
SGTC_1072 oxiconazole 14.9 nM -0.596299181406769 0.318688059255143 no 2306 0.275487688909523 3532 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1734 st037168 69.4 µM -0.596508448385332 0.318627560789571 no 2307 0.275417805829752 3457 708907
SGTC_1981 st071826 47 µM -0.597641453031356 0.318300096469769 no 2308 0.275039599253013 3478 11838600
SGTC_749 1000-0129 128 µM -0.597670883999472 0.318291592135501 no 2309 0.275029778355878 3561 708470
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.597946451141145 0.318211969259507 no 2310 0.274937832013619 3516 16486 A toxic proline analog.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.598497694444632 0.318052717215634 no 2311 0.274753948420136 3487 71034 A hepatoprotective.
SGTC_1137 ixabepilone 100 µM -0.599430778956274 0.317783229397108 no 2312 0.27444282859046 3536 154225 A novel microtubule stabilizer.
SGTC_174 3553-0389 74.3 µM -0.599885555031345 0.317651918691557 no 2313 0.274291254938591 3534 738071
SGTC_2777 climbazole 1.536 µM -0.600637095450033 0.317434971395709 no 2314 0.274040862456741 3485 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3145 9085516 49.47 µM -0.601433861386611 0.317205037310812 no 2315 0.273775525492391 3500 25236195
SGTC_1388 3346-4487 254 µM -0.602442635239209 0.316914022287485 no 2316 0.27343976856178 3521 3345614
SGTC_1249 0481-0015 10.2 µM -0.605099098363491 0.316148217483748 no 2317 0.272556576652645 3473 4227577
SGTC_2094 5332512 191.667 µM -0.605202716336773 0.316118362457716 no 2318 0.272522155597056 3547 755774
SGTC_426 0988-0037 14.6 µM -0.605780557940033 0.315951893292731 no 2319 0.272330240862032 3555 5383008
SGTC_2718 lomofungin 53.02 µM -0.606606824842627 0.315713920641373 no 2320 0.272055934963676 3548 5351222 A RNA synthesis inhibitor.
SGTC_229 benomyl 22.8748 µM -0.607740375422233 0.315387571677895 no 2321 0.271679840015183 3528 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_104 0074-0074 590.992 µM -0.60860722288576 0.315138103610083 no 2322 0.271392407878106 3425 3943124
SGTC_2404 5161160 200 µM -0.608715246794259 0.315107021558127 no 2323 0.271356599575077 3526 2831543
SGTC_1702 st027038 51 µM -0.609579859936587 0.314858290939071 no 2324 0.271070078169073 3534 5521182
SGTC_2068 5226020 147 µM -0.610040027591387 0.314725944819924 no 2325 0.270917646218984 3517 1810509
SGTC_1539 benzyladenosine 56 µM -0.610701356417472 0.314535785591451 no 2326 0.270698653945502 3501 92208 A nucleotide analog.
SGTC_2819 7996655 46.38 µM -0.610837363602951 0.314496684030315 no 2327 0.270653627518707 3412 6456960
SGTC_3258 9138477 49.47 µM -0.612530256906391 0.314010157738525 no 2328 0.27009349286484 3566 4970355
SGTC_1252 0493-0875 34.8 µM -0.612632265262819 0.313980851527522 no 2329 0.270059759469663 3519 3960963
SGTC_1289 0976-0073 69.1 µM -0.613557627408988 0.313715055758881 no 2330 0.26975384550286 3566 3391136
SGTC_3046 9092212 49.47 µM -0.614435185223373 0.313463080329036 no 2331 0.269463895503583 3534 25236637
SGTC_2989 9073649 71.4286 µM -0.616646426500094 0.312828547071948 no 2332 0.26873398246711 3546 21367202
SGTC_230 MPP+ 141.667 µM -0.616697670764471 0.31281384868628 no 2333 0.268717078928992 3524 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_769 0302-0231 76 µM -0.616994177560201 0.312728807524039 no 2334 0.268619283077736 3568 571869 YER009W NTF2
SGTC_628 1636-0253 16 µM -0.6173141551803 0.312637045872854 no 2335 0.268513765992224 3517 4456143
SGTC_1871 st057448 67.3 µM -0.618570255293767 0.312276939802198 no 2336 0.268099750996934 3641 691747
SGTC_326 k292-0812 17.5 µM -0.618776487641985 0.312217833037444 no 2337 0.26803180681375 3523 3579357
SGTC_574 1315-0397 40 µM -0.620108430838473 0.311836210863502 no 2338 0.26759320097594 3593 6794277
SGTC_1641 st009299 47.1 µM -0.620169737487329 0.311818650425688 no 2339 0.267573021550836 3514 4046054
SGTC_974 1326-0144 138 µM -0.62044076672917 0.311741022991583 no 2340 0.267483819959408 3546 5411856
SGTC_374 0880-0231 82.3 µM -0.620805420405633 0.311636593107502 no 2341 0.267363828205522 3539 6833587
SGTC_2553 4-methylesculetin 85.09 µM -0.621297023565646 0.311495831280615 no 2342 0.267202105858728 3535 5319502
SGTC_1862 st057513 3.81 µM -0.621604844480352 0.311407706256777 no 2343 0.267100867370725 3526 5393163
SGTC_2050 5263056 171 µM -0.623077320320843 0.310986305589344 no 2344 0.266616856334645 3544 763468 YGL055W OLE1
SGTC_1798 st045719 60.953 µM -0.626040379529948 0.310139073321221 no 2345 0.265644228131376 3512 3980186
SGTC_3226 9131256 49.47 µM -0.630024815241226 0.309001384884268 no 2346 0.264339174295396 3483 17178073
SGTC_477 mead ethanolamide 10 µM -0.631307131762506 0.308635629674494 no 2347 0.263919862349466 3454 16061185
SGTC_3124 9127567 49.47 µM -0.632994264568358 0.308154697812751 no 2348 0.263368694193668 3556 17592030
SGTC_785 1270-0111 65.3 µM -0.633284754732356 0.308071924265101 no 2349 0.263273853520206 3561 6741994
SGTC_2117 5521686 200 µM -0.634165537401239 0.3078210098525 no 2350 0.262986397873582 3551 803312
SGTC_2894 9048625 32.47 µM -0.637713347667862 0.306811232260595 no 2351 0.261830147591252 3644 4092861
SGTC_24 0417-1663 219 µM -0.643189289535029 0.305255545428534 no 2352 0.260050641096802 3579 4329390
SGTC_449 xestospongin c 11.1929 µM -0.643736405754701 0.305100305023339 no 2353 0.259873189036683 3553 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_681 1642-0006 26.6 µM -0.644931477150166 0.304761333827959 no 2354 0.259485796097098 3599 4446530
SGTC_1027 k015-0025 8.67 µM -0.646849462160906 0.304217664988129 no 2355 0.258864688352637 3583 3598955
SGTC_1713 st033146 12.748 µM -0.648141872041355 0.303851564454101 no 2356 0.25844659698735 3612 674619
SGTC_424 splitomicin 100 mM -0.648262008380721 0.303817543456663 no 2357 0.258407750958736 3558 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_609 0986-0026 86.3 µM -0.648652417828602 0.303706996481946 no 2358 0.258281533139407 3587 2848610
SGTC_2738 aclarubicin 5.55 µM -0.648919501378891 0.303631380380312 no 2359 0.258195204501337 3499 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_894 0960-0238 55.9 µM -0.649595833510135 0.303439936329792 no 2360 0.257976662554999 3584 6741907 YDL195W SEC31
SGTC_1836 st055642 81 µM -0.649626986111462 0.303431119505696 no 2361 0.257966598584925 3544 8571
SGTC_2222 6885208 172.143 µM -0.651526607690779 0.302893704135484 no 2362 0.257353303454723 3570 609514
SGTC_2424 5537928 59.2 µM -0.651780578331534 0.30282188648297 no 2363 0.257271366186291 3622 5382802
SGTC_379 3970-0972 5.9 µM -0.652751783398635 0.302547320106123 no 2364 0.256958156310188 3591 2898042 YBL034C STU1
SGTC_2877 9040724 71.43 µM -0.656768620059891 0.301412919789581 no 2365 0.255664852141775 3605 6463895
SGTC_1554 st069299 38.7 µM -0.657300460350011 0.301262865684846 no 2366 0.255493870275738 3598 24207999
SGTC_2001 4023502 57.655 µM -0.657384957511806 0.301239028644316 no 2367 0.255466710699674 3594 108941 YCR052W RSC6
SGTC_2431 5490079 200 µM -0.658443579224501 0.300940458580609 no 2368 0.255126570148489 3619 5722345
SGTC_1563 conessine 56.1 µM -0.658985002488651 0.300787808998287 no 2369 0.254952699686957 3677 441082 An anti-amoebic, histamine inhibitor.
SGTC_91 0417-1751 58.384 µM -0.659362945733887 0.300681271894613 no 2370 0.254831365290756 3686 6795624
SGTC_3192 9110362 49.47 µM -0.663933822943256 0.299394154176649 no 2371 0.253366333677675 3678 16649480
SGTC_2714 st079313 56.9 µM -0.663947426168115 0.299390327362801 no 2372 0.253361980266235 3626 2939799
SGTC_1758 st042942 75.2445 µM -0.66459295566477 0.299208754665231 no 2373 0.253155438031326 3589 669317
SGTC_1079 idarubicin 2.36 µM -0.664682696835562 0.299183516481146 no 2374 0.253126731651447 3593 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_903 1134-0042 114 µM -0.665056671776744 0.299078352767337 no 2375 0.253007123091792 3610 701009
SGTC_2256 7954252 200 µM -0.666150493271493 0.298770860798855 no 2376 0.252657456475152 3567 2972920
SGTC_700 3453-2283 142 µM -0.667198870816182 0.298476278833603 no 2377 0.252322556157571 3685 565664
SGTC_2589 lobaric acid 100 µM -0.668324746976193 0.298160067903515 no 2378 0.25196315997909 3609 73157 A novel microtubule depolymerizer.
SGTC_2076 5212012 200 µM -0.671028965552195 0.297401191575374 no 2379 0.251101038643717 3529 604802
SGTC_804 1595-0054 20.9 µM -0.67193274457449 0.297147763758192 no 2380 0.250813256696717 3622 761523 Stimulates phospholipase C.
SGTC_324 1315-0088 19.6 µM -0.672831728277752 0.296895778582535 no 2381 0.250527175001085 3586 6787421
SGTC_405 ebelactone b 50 µM -0.673209231875884 0.296789993464841 no 2382 0.250407094389511 3625 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_10 0279-0212 42.575 µM -0.675699096375028 0.296092709249288 no 2383 0.249615854902985 3656 39851 YBR002C RER2
SGTC_1183 1254-0324 198 µM -0.677997529416483 0.295449703347305 no 2384 0.248886629840831 3658 5799357
SGTC_1073 triclabendazole 3.09 µM -0.680968253074727 0.294619571412279 no 2385 0.247945789338471 3697 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2383 9036125 200 µM -0.681643635397217 0.294430994411552 no 2386 0.24773215806751 3598 79580
SGTC_963 1269-2853 151 µM -0.682308495810763 0.294245409730387 no 2387 0.247521951039218 3634 3668223
SGTC_1925 st057770 10.1 µM -0.68365092793664 0.293870857015093 no 2388 0.247097808722981 3599 5989122
SGTC_98 0074-0023 107.663 µM -0.683905187846314 0.293799940667355 no 2389 0.247017518949462 3620 3563821
SGTC_527 4476-4215 268 µM -0.685963600786504 0.293226114649897 no 2390 0.246368030950695 3638 4418754
SGTC_1693 xanthone 101.9 µM -0.687629002826467 0.292762229295948 no 2391 0.245843219705824 3700 7020 An insecticide.
SGTC_3071 9117417 49.47 µM -0.688388047242227 0.292550916229521 no 2392 0.245604224406566 3585 45595590 YGL055W OLE1
SGTC_2644 guaiazulene 100 µM -0.68907999073762 0.292358345403793 no 2393 0.245386465508172 3676 3515 A coloring agent.
SGTC_2062 5245942 200 µM -0.689149465888511 0.292339013429711 no 2394 0.245364606981989 3728 1376160
SGTC_2154 5570129 200 µM -0.689810609651419 0.292155075045216 no 2395 0.245156647886251 3672 673366
SGTC_1728 st035614 33.7865 µM -0.689871594615286 0.292138110986128 no 2396 0.245137470180733 3655 15945546
SGTC_317 4495-0002 170 µM -0.690011323203596 0.292099244707124 no 2397 0.245093533314549 3640 15991618
SGTC_1487 3970-0795 2.82 µM -0.690547471395651 0.291950134462978 no 2398 0.24492498385454 3711 3765103
SGTC_3351 9150312 21.596 µM -0.691179203348914 0.291774486551351 no 2399 0.244726465698481 3635 4904905
SGTC_1680 diphenhydramine 100 µM -0.694516268688599 0.290847460851593 no 2400 0.243679250956722 3691 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_651 3253-0966 34.4 µM -0.694780465252627 0.290774126775594 no 2401 0.243596446103353 3687 781462
SGTC_2103 5378138 10 µM -0.694817650394736 0.290763805844027 no 2402 0.243584792704585 3708 244142
SGTC_423 5-fluorouracil 457 µM -0.696063104670809 0.290418222457818 no 2403 0.243194655533976 3642 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_298 1391-0729 10 µM -0.696628809299004 0.29026131666076 no 2404 0.243017560819817 3639 3237558
SGTC_2931 9014674 55.67 µM -0.697017193300026 0.290153616121672 no 2405 0.242896016999409 3677 2996810
SGTC_2812 7970281 58.44 µM -0.697042179203624 0.29014668806522 no 2406 0.242888198848384 3687 2233435
SGTC_2927 9011802 47.9 µM -0.697446268290366 0.290034653573268 no 2407 0.242761777283564 3657 43912568
SGTC_3163 9099914 49.47 µM -0.697631314842431 0.289983355824152 no 2408 0.24270389631073 3678 16268368
SGTC_2813 7971799 71.43 µM -0.698887741442134 0.289635167601726 no 2409 0.242311094499488 3698 2234054
SGTC_205 1486-1330 71.903 µM -0.699166655573611 0.289557899927605 no 2410 0.242223943179765 3661 4118834
SGTC_1868 st057644 42.7 µM -0.699589834509543 0.289440685013228 no 2411 0.242091746395261 3688 688665
SGTC_3127 9126946 49.47 µM -0.700290075485693 0.289246776582827 no 2412 0.24187308420832 3635 27243249
SGTC_2160 5660466 132.927 µM -0.700504412341832 0.289187435332949 no 2413 0.241806175295269 3633 2859134
SGTC_2337 9009472 200 µM -0.702979349230047 0.288502639884243 no 2414 0.241034309512342 3695 5742383
SGTC_3082 9117008 49.47 µM -0.703716578367924 0.288298802233045 no 2415 0.240804646969534 3721 41448529
SGTC_2993 9054257 71.4286 µM -0.704402221420876 0.288109288674918 no 2416 0.240591161494237 3683 6470217 YGL055W OLE1
SGTC_1849 st056239 19.2 µM -0.707108378714488 0.287361874089403 no 2417 0.239749564747321 3670 5393181
SGTC_2328 6201408 200 µM -0.708547906088079 0.286964664594374 no 2418 0.23930253675735 3676 2890418
SGTC_942 3253-1115 227 µM -0.708574412725616 0.286957353044198 no 2419 0.239294309710004 3723 46497897
SGTC_2357 9067248 200 µM -0.709421213966543 0.286723819147885 no 2420 0.239031563520585 3693 9150235
SGTC_2961 9083290 32.55 µM -0.709895093948432 0.286593170152952 no 2421 0.238884596501554 3659 17741490
SGTC_3032 9089427 49.47 µM -0.710207483781539 0.286507059534052 no 2422 0.238787740348334 3667 17173707
SGTC_2918 7977171 22.06 µM -0.710622183014083 0.286392766178681 no 2423 0.238659196463518 3644 2236483
SGTC_2585 alliin 100 µM -0.712220121470471 0.28595256814844 no 2424 0.238164239409618 3761 87310 A garlic compound which reacts with lipids.
SGTC_192 3455-0609 60.9 µM -0.713585202748472 0.285576772230247 no 2425 0.237741855104203 3739 3769639
SGTC_1992 st073643 23.3 µM -0.713763355137325 0.285527745652489 no 2426 0.237686761409323 3682 3161292
SGTC_2306 7482397 179.52 µM -0.714331858141112 0.285371323485878 no 2427 0.237510998485227 3697 891448
SGTC_2485 5633444 17.78 µM -0.71448538121382 0.285329088999893 no 2428 0.237463546303907 3698 5724239
SGTC_1062 mesoridazine 14.2 µM -0.714523671524333 0.285318555727392 no 2429 0.237451712028901 3694 4078 A neuroleptic.
SGTC_2170 morpholine 200 µM -0.714966352075894 0.285196792290371 no 2430 0.237314917548804 3723 121171 Reacts with secondary amines.
SGTC_1118 chelidonine 707.474 nM -0.718052267203949 0.28434867112891 no 2431 0.236362530030881 3707 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3287 9117173 37.0625 µM -0.71807540734856 0.284342315935391 no 2432 0.236355396383907 3687 2789709
SGTC_1915 st067105 30.6 µM -0.720542196421615 0.283665228300084 no 2433 0.235595614511795 3700 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1358 1509-0022 2.48 µM -0.721431754357767 0.283421250824651 no 2434 0.235321957653381 3728 3258434
SGTC_1409 3909-8004 61.9 µM -0.721835891556199 0.283310442074527 no 2435 0.235197689942552 3729 2119279
SGTC_954 1189-0853 2.85 µM -0.72275516776842 0.283058466838408 no 2436 0.23491515770242 3691 2828194
SGTC_1150 3909-7983 10.9 µM -0.723757687762091 0.28278379700637 no 2437 0.234607255065389 3718 23965914
SGTC_1955 wogonin 32.4 µM -0.724418914671389 0.282602704553632 no 2438 0.234404295537951 3745 5281703 A flavanone.
SGTC_1463 k081-0032 34.1 µM -0.724698798470166 0.282526068624982 no 2439 0.234318416204671 3553 977755
SGTC_1379 2144-0755 36.5 µM -0.724858840080699 0.282482251581654 no 2440 0.234269316984849 3755 5392327
SGTC_2907 7721985 69.9 µM -0.725670158516157 0.28226017479234 no 2441 0.234020499961754 3692 3267881
SGTC_689 0833-0039 98 µM -0.726106423421808 0.282140793651931 no 2442 0.233886765768412 3708 5374726
SGTC_978 1416-0512 87.4 µM -0.727784790237923 0.281681745931015 no 2443 0.233372668276675 3775 6814003
SGTC_3263 9137018 49.47 µM -0.7277963469242 0.281678586326898 no 2444 0.233369130543844 3681 43844957
SGTC_1335 1486-0900 202 µM -0.727866479996231 0.281659412274562 no 2445 0.233347662045876 3727 X1335
SGTC_2825 7998094 58.44 µM -0.728399765665703 0.281513635068677 no 2446 0.233184453340189 3719 2987815
SGTC_1028 k015-0029 4.8 µM -0.728557264988664 0.281470588538106 no 2447 0.233136263792132 3710 4588309
SGTC_2419 paclitaxel 166.5 µM -0.728570173850576 0.28146706052586 no 2448 0.233132314355414 3669 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3030 9087619 49.47 µM -0.728600741151881 0.281458706519456 no 2449 0.233122962507748 3717 25236973
SGTC_380 3970-0968 6 µM -0.730045462869908 0.281064002336085 no 2450 0.232681197832285 3677 2891601
SGTC_2212 7123476 200 µM -0.73031913777176 0.28098926331362 no 2451 0.232597566412699 3678 1085715
SGTC_1128 3448-9350 235 µM -0.73254118212056 0.280382791749395 no 2452 0.231919158152336 3776 619386
SGTC_873 0591-4978 488 µM -0.732964884767959 0.28026722085958 no 2453 0.231789923486702 3758 3305145
SGTC_2814 7977482 42.97 µM -0.733980080217475 0.279990405855993 no 2454 0.231480439317971 3810 6456762
SGTC_404 fumagillin 50 µM -0.734968898534008 0.279720910642541 no 2455 0.231179217879337 3725 12015870 A methionine aminopeptidase binder.
SGTC_2084 5306078 60.6385 µM -0.735105081539213 0.279683804822199 no 2456 0.231137749906693 3666 679340
SGTC_2626 ethyl orsellinate 100 µM -0.735232078670417 0.279649204032069 no 2457 0.231099082789916 3728 75653 A natural product.
SGTC_665 3914-0008 307 µM -0.735673138300019 0.279529052011366 no 2458 0.230964820365733 3713 1069549
SGTC_1833 st055984 71 µM -0.737631881800565 0.278995760560094 no 2459 0.230369088063461 3772 676288
SGTC_688 0527-0193 473 µM -0.73817089279745 0.278849095213214 no 2460 0.230205304109463 3765 4007154
SGTC_483 fpl-64176 144 µM -0.742345847067195 0.277714359113594 no 2461 0.228938910331665 3766 3423
SGTC_3247 9135149 49.47 µM -0.746578908166316 0.276566137218026 no 2462 0.227658891981925 3722 8934436 YOR116C RPO31
SGTC_1448 4255-0083 152 µM -0.749762295478023 0.275704176228632 no 2463 0.226698940486671 3797 5399660
SGTC_664 1222-0054 14.9 µM -0.750090613944666 0.275615353107209 no 2464 0.226600066053497 3732 6813991
SGTC_2360 9040895 200 µM -0.753482190417493 0.274698621898389 no 2465 0.225580104727722 3779 4914414
SGTC_1423 4048-0112 5.59 µM -0.753792779702516 0.274614745917986 no 2466 0.22548683009812 3774 X1423
SGTC_1743 st037606 46.3785 µM -0.754331026084152 0.274469420075203 no 2467 0.225325238331016 3777 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2211 7117706 200 µM -0.754347896059168 0.274464865816733 no 2468 0.225320174704795 3686 822771
SGTC_277 nystatin 15.5 µM -0.755140429120929 0.274250953749403 no 2469 0.225082363689885 3752 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2243 6634756 200 µM -0.755516346806658 0.274149518853435 no 2470 0.224969613893112 3790 885676
SGTC_1879 gemcitabine 100 µM -0.756469324369303 0.273892457384892 no 2471 0.224683928772817 3762 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2640 pentamidine 10.38 µM -0.75793747934465 0.273496662447329 no 2472 0.224244205895053 3788 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1668 st014914 51.6 µM -0.75850064541219 0.27334491557413 no 2473 0.224075663395386 3770 2839556
SGTC_1168 k815-0004 80.5 µM -0.760299662080807 0.272860444379955 no 2474 0.223537741909577 3754 642433
SGTC_3337 9144342 33.5465 µM -0.760504631509631 0.272805273605468 no 2475 0.22347650092831 3776 17682949
SGTC_84 0443-0269 128.823 µM -0.762199779060216 0.272349209981455 no 2476 0.222970388976861 3680 6150058
SGTC_1855 st056195 39.6 µM -0.763773807188916 0.271926071810904 no 2477 0.222501024172722 3712 4028379
SGTC_468 gf-109203x 121 µM -0.764033067014964 0.271856407659235 no 2478 0.222423768682566 3725 2396 A protein kinase C inhibitor.
SGTC_641 4092-0595 30 µM -0.764388198065735 0.271760996940679 no 2479 0.222317969859246 3828 786260
SGTC_668 1682-0499 62.6 µM -0.76522972668367 0.271534975548972 no 2480 0.222067380620051 3799 682214
SGTC_1844 rapamycin 4 nM -0.767070018551074 0.271041028466945 no 2481 0.221519943253325 3726 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1817 st052116 64.4 µM -0.767366183299437 0.270961577686343 no 2482 0.221431914320734 3768 4361398
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.767857726073288 0.270829739376161 no 2483 0.221285857406519 3769 688803
SGTC_2958 9077254 16.72 µM -0.769231562807409 0.270461427973986 no 2484 0.220877928202479 3796 16457351
SGTC_1148 3909-7663 27.7 µM -0.76999824850311 0.270255996346969 no 2485 0.220650465827791 3846 4084526
SGTC_1193 1488-0126 41.5 µM -0.771127031980754 0.269953683536517 no 2486 0.220315819640187 3795 1384710
SGTC_2010 4012422 159 µM -0.771149290530883 0.269947723913865 no 2487 0.220309223658388 3788 952393
SGTC_1270 0831-1170 17.3 µM -0.772180002264569 0.269671827814054 no 2488 0.220003911985915 3781 6764716
SGTC_1791 st048313 56.1 µM -0.774061299910191 0.269168615311361 no 2489 0.219447270883627 3727 1204976
SGTC_35 0133-0054 64.071 µM -0.774517281785753 0.269046719517094 no 2490 0.219312476225101 3787 99677
SGTC_930 2810-3379 265 µM -0.774566555023211 0.269033549160244 no 2491 0.219297913212104 3804 1015764
SGTC_1155 4088-0394 48.2 µM -0.777757391643918 0.268181352683281 no 2492 0.21835602554449 3781 2326248
SGTC_615 k087-0205 167 µM -0.77837870704464 0.268015572279608 no 2493 0.218172893882165 3797 9642773
SGTC_421 streptovitacin 30 mM -0.778784365357584 0.26790736170451 no 2494 0.218053374557454 3897 91467 include heat shock
SGTC_1405 3909-7894 12 µM -0.779300369783573 0.267769747775099 no 2495 0.217901398453122 3799 7104060
SGTC_2386 9075165 157.42 µM -0.779928295790615 0.267602333380017 no 2496 0.21771654108534 3768 16452277
SGTC_1290 0986-0249 10.2 µM -0.780619313762919 0.26741815873407 no 2497 0.217513214458266 3738 53329
SGTC_1548 st061468 90.8 µM -0.780985122456154 0.267320686887645 no 2498 0.217405622499381 3791 390799
SGTC_3256 9138902 49.47 µM -0.78262854155151 0.266883009617197 no 2499 0.216922637968194 3835 17228773
SGTC_3356 9151811 4.48 µM -0.783330196176897 0.266696254489999 no 2500 0.216716617729684 3797 1859254 YPR165W RHO1
SGTC_252 miconazole 1.30953 nM -0.784107883905926 0.266489339310117 no 2501 0.216488404877139 3757 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1065 prochlorperazine maleate 2.48 µM -0.789079786155756 0.265168413959069 no 2502 0.215032687740288 3850 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1640 st009078 66.4 µM -0.79023557312613 0.2648618237258 no 2503 0.214695102321532 3792 690618
SGTC_2922 7999257 32.47 µM -0.790471771649692 0.264799190623389 no 2504 0.214626150732154 3794 2988377
SGTC_1439 4092-1168 46 µM -0.790859394471881 0.264696420442683 no 2505 0.214513022927822 3812 2886240
SGTC_1521 st012942 49.4 µM -0.794286360660122 0.263788714437365 no 2506 0.213514371239754 3867 24207259
SGTC_2275 7947463 200 µM -0.796964368091447 0.263080492835734 no 2507 0.212735862826582 3766 1225414
SGTC_361 000s-0510 1.45 µM -0.797035749576162 0.263061628704904 no 2508 0.212715134619414 3836 660
SGTC_323 4013-0906 34.3 µM -0.797561740547692 0.26292264531325 no 2509 0.21256243039657 3854 2910086
SGTC_1258 0671-0043 57.1 µM -0.797999251951051 0.262807069618435 no 2510 0.212435462106083 3854 4298767
SGTC_1708 st033234 31.827 µM -0.798232416963892 0.262745485934289 no 2511 0.212367814400646 3907 674664
SGTC_2471 5466956 24.79 µM -0.798544633680343 0.26266303462802 no 2512 0.212277251295935 3788 724419
SGTC_3021 9087658 49.47 µM -0.798586565972187 0.262651962007 no 2513 0.212265089930289 3768 25237042
SGTC_857 0438-0306 1.35 µM -0.799591949627335 0.262386552407306 no 2514 0.211973626622327 3907 4686136
SGTC_1003 4049-0218 100 µM -0.800357518397329 0.262184543293913 no 2515 0.211751843335808 3840 295161
SGTC_1458 k015-0034 6.33 µM -0.800919921086317 0.262036194000243 no 2516 0.211589003290146 3865 3598957
SGTC_567 1080-0542 68.4 µM -0.801078763876239 0.261994302606512 no 2517 0.21154302467209 3729 5950415
SGTC_1482 3346-2049 8.48 µM -0.803051931707164 0.261474208107838 no 2518 0.210972359548468 3846 3826804
SGTC_1274 0865-0114 173 µM -0.803111752639303 0.261458448580225 no 2519 0.210955072684937 3854 870624
SGTC_27 0485-0001 32.618 µM -0.805258342100898 0.260893263178572 no 2520 0.210335307812288 3773 2054479
SGTC_2114 5491910 81.25 µM -0.805582161390735 0.260808057889127 no 2521 0.210241907360059 3920 2849228
SGTC_868 0527-0199 213 µM -0.806364927958362 0.260602150762797 no 2522 0.210016231593842 3799 2849450
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.806422874272097 0.260586911284187 no 2523 0.20999953102366 3866 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1911 st060208 74.3 µM -0.806561724598699 0.260550396478143 no 2524 0.209959516474462 3901 688783
SGTC_1232 0279-0259 161 µM -0.808376640511073 0.260073352954141 no 2525 0.209436897534094 3846 1560000
SGTC_3276 9139060 49.47 µM -0.809577535829134 0.259757950075723 no 2526 0.20909151170498 3913 4870619
SGTC_1926 methyl fluorone black 53.6 µM -0.810799843337148 0.259437126325874 no 2527 0.208740312239304 3654 72721 Reacts with homocysteine.
SGTC_198 3454-2873 16.191 µM -0.811061238497781 0.259368543508341 no 2528 0.208665252029979 3831 710957
SGTC_183 3914-0051 30.55 µM -0.814273401435934 0.258526526740968 no 2529 0.207744171899673 3878 1596232
SGTC_311 1315-0136 58 µM -0.814420423740036 0.25848802112226 no 2530 0.207702071159438 3922 6759207
SGTC_2058 5236698 133 µM -0.816226320955571 0.258015293232757 no 2531 0.207185352710446 3856 766665
SGTC_3354 9151612 71.43 µM -0.816904041395838 0.257838002825358 no 2532 0.206991634033889 3886 27261949
SGTC_2859 9028643 45.46 µM -0.817567130990697 0.257664601025948 no 2533 0.206802201190051 3775 17151580
SGTC_1763 st044482 94.5 µM -0.821253683626073 0.256701651218813 no 2534 0.205750891880169 3902 88505
SGTC_621 3584-0052 32.1 µM -0.82139425638862 0.256664969885064 no 2535 0.205710867043735 3838 2273927
SGTC_633 0437-0093 97.7 µM -0.82159513002716 0.256612558258848 no 2536 0.205653680950295 3819 2831118
SGTC_4 0960-0234 25.671 µM -0.821893927246959 0.256534606882469 no 2537 0.205568634755327 3868 6821112
SGTC_2394 5221648 200 µM -0.822659219202319 0.25633501081941 no 2538 0.20535090612345 3947 788586
SGTC_2691 st077356 60.2 µM -0.823439443664622 0.256131603559303 no 2539 0.205129070203762 3936 2839272
SGTC_3033 9090887 49.47 µM -0.824357132554424 0.255892466610937 no 2540 0.204868332302216 3897 19325384
SGTC_2477 5967686 25.23 µM -0.825435740401656 0.255611545449108 no 2541 0.204562125455236 3866 776118
SGTC_656 4090-1979 187 µM -0.826763545926716 0.255265942590597 no 2542 0.204185547902048 3881 22330961
SGTC_1698 5-fluorocytosine 1.055 µM -0.828274320433271 0.254873013650196 no 2543 0.203757581213956 3905 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2449 5812982 45.77 µM -0.828495932933642 0.254815402322549 no 2544 0.203694848637715 3850 776185
SGTC_1159 4092-0538 61.2 µM -0.830422122341667 0.25431494919818 no 2545 0.203150081077041 3908 717301
SGTC_1127 asiatic acid 681.4 nM -0.832133672601589 0.253870695274736 no 2546 0.202666748597046 3858 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1197 1601-0112 267 µM -0.833319251303573 0.253563202712877 no 2547 0.202332350878356 3859 7350313
SGTC_3142 9086498 49.47 µM -0.833517808556825 0.253511723892818 no 2548 0.202276379204917 3832 25236367
SGTC_909 3448-9333 149 µM -0.833942924537376 0.253401524935617 no 2549 0.202156573616851 3809 3344074
SGTC_3242 9133940 49.47 µM -0.834725013914856 0.253198856787892 no 2550 0.201936277219474 3896 17248444
SGTC_853 0419-0306 21 µM -0.834992955481858 0.253129442873946 no 2551 0.201860837371217 3890 762713
SGTC_1498 4478-3555 97.6 µM -0.835107382246834 0.253099802111615 no 2552 0.201828625273563 3824 3437919
SGTC_2840 9008771 71.43 µM -0.837521678401163 0.25247483605125 no 2553 0.201149698367003 3855 2992978
SGTC_1632 st005650 90 µM -0.838310646781667 0.252270779689753 no 2554 0.200928128945457 3922 2759605
SGTC_2171 5739187 198.077 µM -0.84015196496321 0.251794885306774 no 2555 0.20041159354271 3816 2262761
SGTC_75 0159-0059 199.013 µM -0.841049034221236 0.25156320680845 no 2556 0.20016023259953 3922 5377270
SGTC_2693 st077581 40.7 µM -0.844443668325048 0.250687523779451 no 2557 0.199210764549401 3951 25238761
SGTC_3 0833-0587 95.581 µM -0.845252430716826 0.250479133050526 no 2558 0.198984957129102 3824 5382644
SGTC_544 k015-0020 52.4 µM -0.846296486930107 0.250210250862064 no 2559 0.198693683582766 3907 3008304
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.846903021512673 0.250054116618886 no 2560 0.198524589098502 3939 279621
SGTC_2556 citropten 84.59 µM -0.846990950084715 0.250031486320561 no 2561 0.198500082885634 3943 2775 A potential DNA crosslinker.
SGTC_3332 9141069 11.198 µM -0.847114541460203 0.249999679274407 no 2562 0.198465640324064 3835 17332883
SGTC_1506 4226-2149 212 µM -0.847726948752186 0.249842103948839 no 2563 0.198295027283132 3924 991114
SGTC_1250 0485-0349 40.2 µM -0.847760777954273 0.249833401070305 no 2564 0.198285605248703 3917 6842794 YDL195W SEC31
SGTC_1966 st070145 16.1 µM -0.848821675310694 0.249560556987894 no 2565 0.197990263592536 3848 3748532
SGTC_654 1124-0271 80.9 µM -0.850744309975537 0.24906649297273 no 2566 0.197455701655418 3899 5403748
SGTC_2185 6113692 200 µM -0.851282847052431 0.248928197166681 no 2567 0.197306125486459 3915 874150
SGTC_299 1273-0059 1.44 µM -0.851603841054886 0.24884578565776 no 2568 0.197217003504017 3810 2848077
SGTC_1884 5633444 25 µM -0.851851088305036 0.24878231768068 no 2569 0.197148373454547 3936 5724239
SGTC_2804 7954240 19.48 µM -0.853320480759742 0.248405304849553 no 2570 0.196740802727691 3946 828705
SGTC_191 3914-0123 66.505 µM -0.853507384468172 0.248357371429988 no 2571 0.196688997174278 3854 3144412
SGTC_171 k064-0041 9.68 µM -0.85356909312112 0.248341546680385 no 2572 0.196671894721893 3935 53325
SGTC_178 4092-0806 87.505 µM -0.856466000568759 0.247599260455014 no 2573 0.195870035611466 3845 2169044
SGTC_76 0433-0009 400.328 µM -0.858362123622659 0.247114051725071 no 2574 0.195346267750501 4025 2841569
SGTC_3136 9095672 49.47 µM -0.861747450553269 0.246249029093478 no 2575 0.194413253954974 3667 17217380
SGTC_1720 st037298 9.481 µM -0.862448724429974 0.2460700419908 no 2576 0.194220318942294 3940 597396
SGTC_3306 9127676 59.7925 µM -0.863232871521169 0.245869985717412 no 2577 0.194004721935025 3927 41905287
SGTC_17 0960-0276 49.807 µM -0.864819004369859 0.24546558908188 no 2578 0.193569069311151 3905 6821114
SGTC_1360 1598-0022 39.8 µM -0.865111509946655 0.245391051609661 no 2579 0.193488793949083 3990 761525
SGTC_395 anisomycin 6.25 µM -0.865619507088237 0.245261630603989 no 2580 0.193349427254057 3933 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2929 9013348 24.6 µM -0.868417801022554 0.2445493753911 no 2581 0.192582826670758 3958 2995952
SGTC_3316 9136639 10.545 µM -0.868845139671285 0.244440702201965 no 2582 0.192465919765497 3951 4903665
SGTC_1768 st044301 37.178 µM -0.872981648099363 0.243390124945729 no 2583 0.191336540361423 3943 3931349
SGTC_32 0928-0142 34.1 µM -0.874393239373074 0.243032172637748 no 2584 0.190952068931223 3889 2244242
SGTC_3106 9121286 49.47 µM -0.878079162709959 0.242098837563902 no 2585 0.189950380050758 3965 15943471
SGTC_2797 7859098 81.82 µM -0.88191585211641 0.241129394208726 no 2586 0.188911156983864 3935 972681
SGTC_68 0986-0284 82.829 µM -0.882329665892745 0.241024959197422 no 2587 0.188799279179721 4038 423278 YIL048W NEO1
SGTC_2037 5169046 200 µM -0.885947962870271 0.2401128509839 no 2588 0.187822784431543 4022 5718022
SGTC_1187 1391-0724 117 µM -0.88611106483951 0.24007178024915 no 2589 0.187778840571981 4007 6997986
SGTC_2857 9024691 58.44 µM -0.888549957799115 0.239458099241257 no 2590 0.187122497776737 4036 16478292
SGTC_2118 5526350 200 µM -0.888859366399768 0.239380306268452 no 2591 0.187039332807749 4010 743594
SGTC_2497 7-hydroxyflavone 100 µM -0.892547832919382 0.238453998497509 no 2592 0.186049683177401 3995 5281894
SGTC_2451 5856223 45.7 µM -0.893442898848348 0.238229511237503 no 2593 0.185810019049164 3930 2179896
SGTC_1178 0988-0033 191 µM -0.893844029862154 0.238128943045107 no 2594 0.185702673803365 4013 5392207
SGTC_2423 st077119 87.2 µM -0.895144675975723 0.237803016066606 no 2595 0.185354877209179 3884 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2663 amphotericin b 100 µM -0.896540854227124 0.237453422285785 no 2596 0.184981985414343 3933 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_737 1950-0117 57.9 µM -0.897954114156896 0.23709983888882 no 2597 0.184605006502791 3904 5393513
SGTC_2571 chrysanthemic acid 100 µM -0.898955141109001 0.23684956716414 no 2598 0.184338277598217 3993 2743 An insecticide.
SGTC_976 1348-1067 47.6 µM -0.9000478809699 0.236576531744873 no 2599 0.18404738520143 3997 5310671 YGL099W LSG1
SGTC_207 4185-0010 4.486 µM -0.900437789978254 0.236479149792165 no 2600 0.183943658840761 4020 3761753
SGTC_568 1193-0097 7.48 µM -0.90214772915468 0.236052343568285 no 2601 0.183489198702929 3837 3646150
SGTC_2330 7979373 200 µM -0.902307455389916 0.236012497081333 no 2602 0.183446783134599 3930 1863007
SGTC_463 ikarugamyin 104 µM -0.902770250984618 0.235897065602582 no 2603 0.183323921506063 4031 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_288 1315-0019 35.1 µM -0.903930313664566 0.235607857072638 no 2604 0.18301617700175 4050 6811474
SGTC_1647 st011722 22.4 µM -0.904117593365937 0.235561185794804 no 2605 0.182966525182025 3941 2854783
SGTC_2680 butyl paraben 22.24 µM -0.905251927083125 0.23527861173912 no 2606 0.182665968932289 4027 7184 An antifungal and steroid mimetic.
SGTC_3298 9116858 71.43 µM -0.90529532947732 0.235267803480231 no 2607 0.182654475038711 4033 2506942
SGTC_747 3448-8087 38.7 µM -0.905651188031415 0.235179196325534 no 2608 0.182560253021123 4012 5168703
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.906269151571045 0.235025370024358 no 2609 0.182396704615125 4025 23847180
SGTC_2618 avocadyne 43.43 µM -0.907377737384219 0.234749555144654 no 2610 0.182103539050089 3900 3015189
SGTC_296 1222-0039 74.9 µM -0.907681538282713 0.234674001080879 no 2611 0.182023250341798 3976 5984176
SGTC_1070 indatraline 8.81 µM -0.908451035374393 0.234482690419742 no 2612 0.181819986175353 3968 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1425 4048-4433 7.33 µM -0.910298262419419 0.234023789298211 no 2613 0.181332617331889 4032 23734946
SGTC_1269 0831-0796 3.05 µM -0.911811313717464 0.233648277373451 no 2614 0.180934026799548 4022 927758
SGTC_2287 7945887 168.79 µM -0.91577724697323 0.232665591818252 no 2615 0.179891869838773 4009 1245853
SGTC_2387 9077560 195.08 µM -0.915824281414994 0.232653951346401 no 2616 0.179879532922582 3965 5303272
SGTC_1131 3454-3128 32.3 µM -0.917437147988255 0.232254981752735 no 2617 0.179456807068011 4054 710982
SGTC_368 fentichlor 4.58 µM -0.917779556722942 0.232170330226474 no 2618 0.179367143540963 4059 7329 A pesticide.
SGTC_1978 st071761 42 µM -0.918370220166383 0.232024344640455 no 2619 0.179212537980903 4014 5147680
SGTC_2053 5265679 138 µM -0.919021538692009 0.231863427096619 no 2620 0.17904215321408 3917 764595
SGTC_1846 st056244 14.8 µM -0.919276968415634 0.231800336508586 no 2621 0.178975360693379 4024 5393182
SGTC_364 0083-0097 67.7 µM -0.919608778097953 0.231718394518754 no 2622 0.178888618933614 4097 5207356
SGTC_1276 0871-0068 94.2 µM -0.920769332229968 0.231431917108125 no 2623 0.17858543478272 4002 3414906
SGTC_1024 4507-0395 26 µM -0.921390794134487 0.231278593344838 no 2624 0.178423216664889 4087 4201836
SGTC_1942 st076330 65.2 µM -0.921641724838821 0.231216701123058 no 2625 0.178357743380939 4014 24208414
SGTC_3148 9097893 49.47 µM -0.923266490641696 0.230816175280325 no 2626 0.177934173027963 3994 17174100
SGTC_1985 st071382 65.5 µM -0.924891378805379 0.230416007095759 no 2627 0.177511205765659 3983 6123237
SGTC_2713 st079149 53.4 µM -0.925068330470869 0.230372451880409 no 2628 0.17746518262997 4030 3103253
SGTC_370 0180-0345 38.7 µM -0.925223019924877 0.230334380098922 no 2629 0.177424955815851 3874 3989527
SGTC_2789 5281112 71.43 µM -0.925727415815091 0.230210263886101 no 2630 0.177293828237214 4032 765948
SGTC_1262 0737-0114 49.6 µM -0.926216499082287 0.230089951366984 no 2631 0.177166739928639 4073 765919
SGTC_172 1112-0046 2.638 µM -0.927331330242622 0.2298158389171 no 2632 0.176877266137409 3980 2802135 YIL048W NEO1
SGTC_2343 7990716 14.84 µM -0.92750721940353 0.229772608348417 no 2633 0.176831622590356 4009 6456862
SGTC_325 2810-4341 181 µM -0.928658786094668 0.229489685343273 no 2634 0.176532972965373 4011 774970
SGTC_2237 6667747 47.222 µM -0.932306434165411 0.228594801577978 no 2635 0.175589091753617 4010 729940 YDL015C TSC13
SGTC_982 1491-0518 27.5 µM -0.933677907648246 0.228258843290951 no 2636 0.175235032161981 3939 3091256
SGTC_2746 daunorubicin 9.88 µM -0.934166115007496 0.228139318270825 no 2637 0.175109105897137 3922 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_73 0327-0325 16.231 µM -0.937542221600176 0.227313729198505 no 2638 0.174239858023628 3917 53298
SGTC_1397 3532-0190 20.1 µM -0.942985547331613 0.225986176724741 no 2639 0.172844147726511 3963 5322280
SGTC_3036 9090181 49.47 µM -0.944904585764329 0.225519196685789 no 2640 0.172353795075091 4045 25236586
SGTC_1325 1431-0015 227 µM -0.945087497058349 0.225474715462177 no 2641 0.172307103954438 4017 1103340
SGTC_1199 1638-0010 4.46 µM -0.946957461566294 0.225020253764196 no 2642 0.171830227755702 4019 3111136
SGTC_2409 alverine citrate 63.97 µM -0.947261227138449 0.22494647797341 no 2643 0.171752841462769 4198 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1205 4161-2785 76 µM -0.947292108367696 0.224938978592038 no 2644 0.171744975511682 4114 3498106
SGTC_493 zm226600 134 µM -0.947437513364858 0.224903669482354 no 2645 0.171707941587693 4076 5240098 A potassium channel opener. YCR052W RSC6
SGTC_726 3448-4391 34.2 µM -0.949271854180211 0.224458501192764 no 2646 0.17124118232989 4147 1356692
SGTC_2568 diosmetin 100 µM -0.950226661171602 0.224226981212643 no 2647 0.170998547185004 4095 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2455 5377712 9.75 µM -0.952486246291225 0.223679621342662 no 2648 0.170425218946024 4034 2243908
SGTC_2641 levomentholum 100 µM -0.953136790657528 0.223522175023916 no 2649 0.170260383765406 4021 16666
SGTC_2872 9044037 25.97 µM -0.954788152961818 0.223122791565776 no 2650 0.169842419841243 4035 6465195
SGTC_2968 9090663 33.37 µM -0.955936063544955 0.222845407907851 no 2651 0.169552268756946 4012 25236811
SGTC_218 alverine citrate 93.75 µM -0.955941427751464 0.22284411215048 no 2652 0.169550913622749 4072 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1427 4048-4900 550 nM -0.956685527782271 0.222664411773567 no 2653 0.169363002479887 4018 24132586
SGTC_1497 4476-2978 41.3 µM -0.957081885672686 0.222568724953627 no 2654 0.169262962908766 4081 1528379
SGTC_848 0368-0089 85.6 µM -0.958186161524898 0.222302259660352 no 2655 0.168984447032868 4053 762535
SGTC_2740 felodipine 17.08 µM -0.959071434789274 0.22208877189762 no 2656 0.168761379793358 4043 3333 L-type calcium channel blocker
SGTC_660 4031-1742 102 µM -0.960976432571997 0.221629769929232 no 2657 0.16828200890166 3961 6738706
SGTC_1225 1216-0074 20.6 µM -0.961151373299578 0.221587645821542 no 2658 0.168238031022069 4063 4241466
SGTC_1692 fluoroquinolonic acid 71 µM -0.961251595421695 0.22156351532411 no 2659 0.168212839783357 4091 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2830 7992007 71.43 µM -0.961515415066195 0.221500002604214 no 2660 0.168146539242863 3928 1952075
SGTC_3178 9107506 49.47 µM -0.963258141498231 0.221080715034992 no 2661 0.167708996944634 4073 8897194
SGTC_953 1188-0045 9.7 µM -0.96569794162895 0.220494480199557 no 2662 0.167097674896225 4080 6144426
SGTC_579 4491-1009 110 µM -0.965916637469744 0.220441975532678 no 2663 0.167042948206695 4162 1271041
SGTC_1892 st058411 7.36 µM -0.966382869559186 0.220330066096086 no 2664 0.166926316361765 4072 3934738
SGTC_1418 3966-3099 2.4 µM -0.966787577769291 0.220232950614681 no 2665 0.166825117824017 4049 740335
SGTC_170 4197-0004 226 µM -0.967801795265515 0.219989682588648 no 2666 0.166571683525188 4091 218692
SGTC_624 k048-0052 28 µM -0.967834922205758 0.219981739433058 no 2667 0.166563409905229 4036 6835531
SGTC_2339 9000433 200 µM -0.967877198313682 0.219971602735168 no 2668 0.166552851619888 4073 2988954
SGTC_2806 7952793 58.44 µM -0.968015814696907 0.219938368055249 no 2669 0.166518235774658 4123 2972490
SGTC_3135 9127742 49.47 µM -0.969383849547365 0.219610522443468 no 2670 0.166176853683147 4130 3643468
SGTC_1648 st011736 69.8 µM -0.971203117479043 0.21917497520223 no 2671 0.165723570888949 4065 2855514
SGTC_427 1354-0053 47.3 µM -0.97372602427889 0.218571793834354 no 2672 0.165096296046795 4149 6813657
SGTC_122 0236-0016 402.397 µM -0.977467108079414 0.217679130067708 no 2673 0.164168976939054 4060 6808838
SGTC_2367 9070478 135.38 µM -0.977589351413017 0.217649996997069 no 2674 0.164138733044149 4014 572802
SGTC_53 0973-0023 39.979 µM -0.978128684806467 0.217521489752104 no 2675 0.16400534116482 3932 674768
SGTC_402 epigallocatechin gallate 10 µM -0.981664393367155 0.21668012001228 no 2676 0.163132606275342 4014 65064 An antioxidant.
SGTC_3214 9129694 49.47 µM -0.982904671497942 0.216385425567681 no 2677 0.162827179230088 4109 17158655
SGTC_89 0302-0250 142.109 µM -0.986438280387798 0.215547100713953 no 2678 0.161959044024544 4156 4203518 YLR208W SEC13
SGTC_1022 4477-0945 21.3 µM -0.986951288913309 0.215425549677422 no 2679 0.161833259460871 4031 4648966
SGTC_598 3937-0236 20.2 µM -0.989000081086689 0.21494051034826 no 2680 0.161331550997709 4151 1379313
SGTC_2307 7538926 6.34 µM -0.9907507005458 0.214526564609613 no 2681 0.160903663715972 4077 96582
SGTC_3288 9119690 36.221 µM -0.99135060275461 0.214384820391811 no 2682 0.160757205902246 4076 17595618 YKL019W RAM2
SGTC_1514 1189-1591 158 µM -0.993175127841132 0.213954058531641 no 2683 0.16031230851135 4109 767698 YMR146C TIF34
SGTC_2516 gossypol 71.55 µM -0.994301274393701 0.213688432254103 no 2684 0.160038107730889 4131 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3044 9093193 49.47 µM -0.996833795825567 0.213091783971763 no 2685 0.159422595507465 4121 25236277
SGTC_1804 st050076 49.1 µM -0.996979776132632 0.213057421453824 no 2686 0.159387163285671 4114 3895976
SGTC_3156 9099931 49.47 µM -0.997383704903309 0.212962356919241 no 2687 0.159289148895423 4116 18111053
SGTC_867 0518-0118 155 µM -0.997495045838689 0.212936157210351 no 2688 0.159262138662351 4057 6848158
SGTC_1019 4262-0212 3.4 µM -0.997919581041749 0.212836276812389 no 2689 0.159159178055664 4100 4677213
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.998022935755955 0.212811964688432 no 2690 0.159134118504232 4081 676296 Flavone; oxidizing agent.
SGTC_144 4161-2749 112.381 µM -0.998957561606844 0.212592186322167 no 2691 0.158907624976799 4028 797501 YMR168C CEP3
SGTC_2125 5246583 200 µM -1.00111282004079 0.212085880362796 no 2692 0.158386133884351 4087 835267
SGTC_980 1473-0395 201 µM -1.00181637844714 0.211920755595151 no 2693 0.158216142680998 3970 768876
SGTC_634 1611-4317 11.2 µM -1.00197572031867 0.21188336859378 no 2694 0.158177659717021 4102 2843522
SGTC_135 0933-0004 26.348 µM -1.00381189565971 0.211452818156208 no 2695 0.157734644756308 4076 21230617 YGL099W LSG1
SGTC_213 1246-0773 967 nM -1.00514401164841 0.211140781591659 no 2696 0.157413755068082 4092 6251622
SGTC_2254 7938975 95.19 µM -1.00516118097881 0.211136761587823 no 2697 0.15740962199891 4177 2969277
SGTC_2464 5717415 7.67 µM -1.00547657314052 0.211062924073158 no 2698 0.157333712238874 4087 5285744
SGTC_420 mitomycin C 81.9 mM -1.00563192490286 0.211026559716467 no 2699 0.157296330445674 4080 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1825 st052143 62.6 µM -1.00607097113167 0.210923808718725 no 2700 0.157190715740883 4136 674173
SGTC_1216 1165-0504 9.65 µM -1.00633272236824 0.210862564435519 no 2701 0.157127772400508 4138 6304004
SGTC_169 k015-0017 16.025 µM -1.00993689682564 0.210020324365648 no 2702 0.156262761937659 4053 1840002
SGTC_1198 1612-1005 86.7 µM -1.01027589250297 0.209941208128322 no 2703 0.156181563877381 4177 6998509
SGTC_2395 5646831 180.19 µM -1.01334019384001 0.209226843712043 no 2704 0.155448847574307 4130 6808628
SGTC_2391 6285546 200 µM -1.01518137301381 0.208798308356176 no 2705 0.155009689027154 4092 846083
SGTC_1891 st059073 26.2 µM -1.01617428943777 0.20856742139785 no 2706 0.154773198717059 4178 688754
SGTC_1151 3909-8316 15.3 µM -1.01642424029021 0.208509323017719 no 2707 0.154713703633655 4146 800431
SGTC_3055 9094636 49.47 µM -1.01670874985857 0.208443203451274 no 2708 0.154646001030353 4133 25236176
SGTC_1940 st075990 51.1 µM -1.01824188463856 0.20808711829435 no 2709 0.154281509522263 4208 1084979
SGTC_627 1391-0720 175 µM -1.01967578587275 0.207754406229744 no 2710 0.153941124613957 4093 997839
SGTC_703 3875-0075 71.8 µM -1.02005422971269 0.207666647299187 no 2711 0.153851371130767 4148 2850814
SGTC_698 k064-0052 127 µM -1.02382155561818 0.206794221152623 no 2712 0.152959783538938 4200 5088751
SGTC_1920 st075728 45.7 µM -1.02573374603138 0.206352233184838 no 2713 0.152508551577241 4100 3400306
SGTC_382 3229-0966 23.2 µM -1.02626891509516 0.206228633346788 no 2714 0.152382422625982 4154 5722370
SGTC_2260 7964312 200 µM -1.03064449119459 0.205219720548462 no 2715 0.151353782042412 4182 231951
SGTC_1223 0764-0573 147 µM -1.03395042472966 0.204459392627717 no 2716 0.150579669977614 4110 1609797
SGTC_1392 3455-1037 33.9 µM -1.03614393935743 0.203955835246518 no 2717 0.150067497962395 4129 981132
SGTC_2400 5203494 178.7 µM -1.03957891757171 0.203168765870523 no 2718 0.149267787936171 4045 6777674
SGTC_1435 4092-0789 56.7 µM -1.04267297219906 0.202461368058633 no 2719 0.14854988988382 4127 2248285
SGTC_2321 7390090 138.78 µM -1.04576988961478 0.201754792493569 no 2720 0.14783364307096 4179 649046
SGTC_2601 securinine 100 µM -1.04665919305994 0.20155216717042 no 2721 0.147628395370008 4104 442872 A GABA receptor antagonist.
SGTC_1114 scopoletin 1.73284 µM -1.04679347975043 0.201521580919419 no 2722 0.147597419130254 4176 5280460 A coumarin with genotoxic properties.
SGTC_3302 9125395 16.351 µM -1.04741290147223 0.201380532292755 no 2723 0.147454591965889 4084 17599668
SGTC_187 1488-2104 32.728 µM -1.04863549870977 0.201102308179053 no 2724 0.147172955568218 4144 2852859
SGTC_2885 9057732 51.95 µM -1.04889820821025 0.201042553985553 no 2725 0.147112485145098 4210 6471414
SGTC_1337 1486-1011 40.3 µM -1.05233622481647 0.200261547171831 no 2726 0.146322658672634 4113 X1337
SGTC_1412 3909-8563 178 µM -1.05743609305324 0.199106384819677 no 2727 0.145156303221194 4227 23767530
SGTC_220 paclitaxel 373.376 µM -1.05765458515381 0.199056984392672 no 2728 0.145106473567836 4114 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3300 9124615 50.48 µM -1.05781811489971 0.199020015626293 no 2729 0.14506918624943 4214 24824903
SGTC_1570 verbenone 133 µM -1.05879971724627 0.198798194166259 no 2730 0.144845501235455 4173 29025 A natural terpanoid with antifungal properties.
SGTC_3066 9117245 49.47 µM -1.05889416785571 0.198776858181096 no 2731 0.144823990328873 4215 17176980
SGTC_1742 st038235 28.8875 µM -1.06343232631707 0.19775333522914 no 2732 0.143792969754061 4205 564103 YBR002C RER2
SGTC_1965 Pectolinarigenin 58.4 µM -1.06459032260051 0.197492675024263 no 2733 0.143530680511634 4118 5320438 An anti-inflammatory.
SGTC_2848 9016370 25.97 µM -1.06581374701224 0.197217513009393 no 2734 0.143253922674865 4155 7894410
SGTC_203 k066-0004 30.888 µM -1.06671892788214 0.197014076939783 no 2735 0.14304938865862 4248 6795412
SGTC_2238 6671620 73.2395 µM -1.06700515926754 0.196949773931066 no 2736 0.142984753101391 4091 729941
SGTC_2340 7987427 183.45 µM -1.06702811705084 0.19694461692502 no 2737 0.142979569727191 4189 2239331
SGTC_1490 4089-0339 670 nM -1.06735190987512 0.196871892061369 no 2738 0.142906477788341 4127 742542
SGTC_1374 2889-5571 141 µM -1.06752042145095 0.196834050277211 no 2739 0.142868448525819 4203 2853281
SGTC_1226 3909-7979 35.4 µM -1.06782566982297 0.19676551342505 no 2740 0.142799578270221 4151 6615510
SGTC_956 1185-0240 191 µM -1.06956810508256 0.196374564439715 no 2741 0.142406879058463 4143 1416193
SGTC_2372 9071633 200 µM -1.07273439335087 0.195665352766225 no 2742 0.141695152125616 4195 21321366
SGTC_155 k072-0202 43.6 µM -1.07321066042009 0.19555880919109 no 2743 0.141588304344717 4130 5857737
SGTC_2282 7944268 200 µM -1.07362837709304 0.195465392667544 no 2744 0.141494636952841 4201 2970414
SGTC_922 1866-0035 480 µM -1.07530325532211 0.19509110172751 no 2745 0.14111948962153 4094 3156169
SGTC_1689 st020265 53.493 µM -1.07861536373363 0.19435221694073 no 2746 0.140379614726911 4176 5758320 YPR016C TIF6
SGTC_1603 st002045 67.8 µM -1.07934493626132 0.194189688857095 no 2747 0.14021699391678 4173 5887985
SGTC_320 4092-0846 5.34 µM -1.08022087873055 0.19399466309479 no 2748 0.140021916532396 4123 1359356
SGTC_2162 5663267 200 µM -1.0812482331223 0.19376607809243 no 2749 0.13979335393795 4173 6456493
SGTC_2612 dictamnine 15.46 µM -1.08159469989687 0.193689026730506 no 2750 0.139716330312495 4122 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_3083 9117465 49.47 µM -1.08315536321346 0.193342179712149 no 2751 0.13936973431041 4177 16420915
SGTC_1666 st014829 29 µM -1.08359638269793 0.193244234796772 no 2752 0.139271897696329 4154 3858230
SGTC_2444 5485484 36.41 µM -1.08657541723808 0.192583421945265 no 2753 0.138612247047823 4256 6790631
SGTC_2038 4100038 30.985 µM -1.08757516350472 0.192361966981999 no 2754 0.138391350022467 4168 3596803
SGTC_1224 0823-0416 294 µM -1.08942974358719 0.19195156937426 no 2755 0.137982210480451 4254 3598164
SGTC_995 3931-2021 34.6 µM -1.08947948302235 0.191940569983804 no 2756 0.137971248818894 4189 730143
SGTC_2229 7354935 190 µM -1.09171410722401 0.191446802740614 no 2757 0.137479391254205 4108 318112
SGTC_2133 5320837 200 µM -1.09231181388923 0.191314864270794 no 2758 0.13734803469866 4230 2841355
SGTC_253 dyclonine 31.25 µM -1.09246484420942 0.191281093141618 no 2759 0.137314417378699 4275 3180 An oral anasthetic.
SGTC_2774 tamoxifen 10.92 µM -1.09406337712747 0.190928543219364 no 2760 0.136963591565666 4165 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1616 st002734 56.1 µM -1.09421031940494 0.190896155715173 no 2761 0.136931373298823 4125 4026101
SGTC_2793 7325131 81.82 µM -1.09487421766458 0.190749868113242 no 2762 0.136785872875516 4148 4176441
SGTC_748 act1.228 77.9 µM -1.09600850530487 0.190500091125844 no 2763 0.13653752619074 4137 4421505 YNR035C ARC35
SGTC_704 1310-0270 142 µM -1.09612497877359 0.190474454339041 no 2764 0.13651204236857 4199 5718033
SGTC_2302 7771753 200 µM -1.09742500148079 0.190188452247009 no 2765 0.136227824580983 4199 2203047
SGTC_2213 7173844 200 µM -1.10085751216092 0.189434576550754 no 2766 0.135479338156412 4156 892728
SGTC_772 k072-0172 35.3 µM -1.10300531307896 0.188963795907397 no 2767 0.135012428932339 4239 5861980
SGTC_3117 9124945 49.47 µM -1.10597649024606 0.188313727228713 no 2768 0.134368347621256 4101 17592065
SGTC_1998 st075797 76.8 µM -1.10958532137079 0.187526003281947 no 2769 0.133588879701173 4192 24208315
SGTC_2683 piperine 63.03 µM -1.10972184868595 0.187496242571807 no 2770 0.133559452465375 4176 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3140 9094243 49.47 µM -1.11141971220563 0.187126380138201 no 2771 0.133193865658691 4186 19291112
SGTC_1244 0416-0015 52.5 µM -1.1181735330345 0.185659600895638 no 2772 0.131746442900594 4183 96201
SGTC_3045 9092950 49.47 µM -1.11869101694964 0.185547509921241 no 2773 0.131635989409694 4156 44120432
SGTC_2014 4013930 200 µM -1.11980611525945 0.185306113891219 no 2774 0.131398196384384 4185 64556
SGTC_384 k007-0144 5.16 µM -1.12195582466264 0.184841296296499 no 2775 0.130940611506731 4154 6824886
SGTC_501 nsc-95397 161 µM -1.12208266268563 0.184813893599496 no 2776 0.130913647342378 4243 262093
SGTC_3277 9138724 49.47 µM -1.12273693239174 0.184672582132618 no 2777 0.130774618799606 4175 15943418
SGTC_2948 9070189 9.45 µM -1.12540500387871 0.184097018532291 no 2778 0.130208725821814 4171 6473636 YDL196W YDL196W
SGTC_3254 9136651 49.47 µM -1.12583880594463 0.184003543229046 no 2779 0.130116877596192 4167 16454030
SGTC_2385 9074692 200 µM -1.12667155491381 0.183824186015443 no 2780 0.129940686646552 4241 17046906
SGTC_1443 4112-3303 14 µM -1.12786801129241 0.183566684310281 no 2781 0.129687832620477 4267 704433
SGTC_2441 5730946 39.09 µM -1.12801221297438 0.183535664367158 no 2782 0.129657380674248 4269 1774275
SGTC_3209 9113616 49.47 µM -1.12803254707387 0.183531290460427 no 2783 0.129653086997244 4277 16649353
SGTC_31 0508-1974 57.237 µM -1.13086471312584 0.182922720483063 no 2784 0.129056018679355 4155 6810525
SGTC_2664 lyso-paf C-16 73.48 µM -1.13095425193925 0.182903501127007 no 2785 0.129037173530252 4196 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1761 st044296 37 µM -1.13190550306291 0.182699394491035 no 2786 0.128837082426032 4209 1826700
SGTC_1921 5740136 50 µM -1.13261839142137 0.182546525781972 no 2787 0.128687270940239 4185 1774243
SGTC_775 4577-0580 57.3 µM -1.13312785181259 0.182437328249748 no 2788 0.128580283352621 4278 2006902
SGTC_3137 9097352 49.47 µM -1.13367021028175 0.182321124211008 no 2789 0.128466454963737 4260 44120435
SGTC_1512 0259-0544 12.2 µM -1.13502000957741 0.182032121254993 no 2790 0.128183467311549 4202 18476
SGTC_393 acivicin 6.25 µM -1.1369384203616 0.181621867114267 no 2791 0.127782014687667 4085 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2197 6588183 93.1375 µM -1.1415364700557 0.180640927051558 no 2792 0.12682337214673 4183 884136
SGTC_3208 9114115 49.47 µM -1.14210923417587 0.180518967655108 no 2793 0.126704308793389 4251 650895
SGTC_2425 5628681 7.85 µM -1.14418318282691 0.180077791340998 no 2794 0.126273837979884 4309 5714958
SGTC_293 4049-0273 38.5 µM -1.14623135732268 0.179642762731381 no 2795 0.1258497182229 4100 1380311
SGTC_2914 7968218 45.32 µM -1.14644986529329 0.179596391044858 no 2796 0.1258045300423 4206 2977111
SGTC_1835 st008666 49.2 µM -1.1479353788575 0.17928133531004 no 2797 0.125497620864598 4169 690455
SGTC_721 1187-1332 279 µM -1.15230884556872 0.178355806358726 no 2798 0.124597091693075 4199 25730
SGTC_2656 pseudo-anisatin 100 µM -1.15381094299106 0.178038622829349 no 2799 0.124288843392205 4272 6708809 A neurotoxin.
SGTC_2352 9027995 87.8 µM -1.1550386077458 0.177779652905423 no 2800 0.124037308358943 4205 2997347
SGTC_200 k038-0079 37.545 µM -1.15714979400452 0.177334864419763 no 2801 0.123605582886811 4211 3436683
SGTC_85 0868-0259 160.055 µM -1.15746799052685 0.177267887193624 no 2802 0.123540604888907 4152 83173
SGTC_2148 5546263 113.568 µM -1.15759431613389 0.177241301331232 no 2803 0.123514814934858 4236 792097
SGTC_2846 9008642 19.48 µM -1.15766891884551 0.177225601996281 no 2804 0.123499586219083 4287 2992898
SGTC_2951 9072950 58.06 µM -1.15857425610201 0.177035153550949 no 2805 0.123314883759057 4213 16488155
SGTC_2909 7941780 10.49 µM -1.15894803893824 0.176956561619264 no 2806 0.123238682899168 4232 1243215
SGTC_2942 9052777 62.25 µM -1.16045748955135 0.176639407447052 no 2807 0.122931295979077 4309 6469503
SGTC_1741 st038134 10.228 µM -1.16253517240697 0.17620344894679 no 2808 0.122509073149797 4302 1272587
SGTC_2584 androsterone 48.74 µM -1.16261820374494 0.176186040711678 no 2809 0.122492220847346 4179 2754130 A steroid.
SGTC_947 3447-0010 211 µM -1.16309522180763 0.176086050858526 no 2810 0.122395435272755 4208 748350
SGTC_2572 astragaloside iv 100 µM -1.1664164177035 0.17539087647049 no 2811 0.121723061915403 4291 45006101 An anti-inflammatory agent.
SGTC_2284 7945075 39.21 µM -1.16676938144148 0.175317098468295 no 2812 0.12165175756804 4233 1245402
SGTC_822 1487-0950 154 µM -1.16787679730803 0.175085749375115 no 2813 0.121428232309814 4261 1958375
SGTC_1504 k297-0033 30 µM -1.1682115847825 0.175015847414285 no 2814 0.121360714340242 4133 4388117
SGTC_290 2043-6722 48.1 µM -1.16838574812174 0.174979489977169 no 2815 0.121325600541831 4271 773758 YLR208W SEC13
SGTC_3025 9087895 49.47 µM -1.16986478342983 0.174670927401184 no 2816 0.121027693978321 4234 17173641
SGTC_1477 0139-0234 16 µM -1.17197399608983 0.174231492593 no 2817 0.120603748254649 4263 620880
SGTC_1986 st071812 45 µM -1.17801379080825 0.172977047958733 no 2818 0.119395554179508 4207 11838594
SGTC_2163 5671233 125 µM -1.17804038524786 0.172971537140471 no 2819 0.119390253210086 4231 701023
SGTC_2662 daunorubicin 22.37 µM -1.18094333812072 0.172370668726389 no 2820 0.118812616692692 4141 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2279 7948423 32.93 µM -1.18312362694889 0.171920257762246 no 2821 0.118380077645185 4264 1247112
SGTC_2908 7930301 100 µM -1.18875438295077 0.170760518447389 no 2822 0.117268166756972 4241 2223178
SGTC_1404 3909-7820 48.3 µM -1.19337351565804 0.169812885760622 no 2823 0.116361561248864 4250 23741373
SGTC_2227 7312221 64.1025 µM -1.19361434440999 0.169763571491235 no 2824 0.116314430119877 4382 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_893 0958-0369 48.9 µM -1.19441809607012 0.169599054528369 no 2825 0.116157230815926 4193 6819948
SGTC_29 0299-0004 12.984 µM -1.19576372834355 0.169323851062486 no 2826 0.115894387097712 4181 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2353 9059630 146.67 µM -1.19768134269995 0.168932163645862 no 2827 0.115520547699279 4321 4779114
SGTC_1515 3460-0031 42.1 µM -1.19782552501412 0.168902736849611 no 2828 0.115492473993736 4228 2876596
SGTC_2783 7738165 71.43 µM -1.19859297386314 0.168746160290178 no 2829 0.115343125776797 4279 17201110
SGTC_2649 anisomycin 9.56 µM -1.19946228398805 0.168568914483083 no 2830 0.115174120862982 4324 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_817 1391-0715 46 µM -1.20049426005726 0.168358657742868 no 2831 0.11497372027231 4269 1353946
SGTC_261 5-fluorouridine 15.376 µM -1.20697317009413 0.167042488062718 no 2832 0.113721238356149 4314 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1143 3454-2408 5.08 µM -1.20901262155262 0.166629556816421 no 2833 0.113328998203705 4294 X1143
SGTC_2972 9093619 59.92 µM -1.21019315627975 0.166390833215793 no 2834 0.11310239178085 4242 25236256
SGTC_386 1509-0011 3.07 µM -1.21088359231274 0.166251318053644 no 2835 0.11297001090007 4289 3107280
SGTC_222 nsc-310342 10.666 µM -1.21277973727476 0.165868556258175 no 2836 0.112607022208261 4312 432556
SGTC_625 k213-0058 121 µM -1.21377225841165 0.165668430106002 no 2837 0.112417351307013 4365 3655420
SGTC_1166 k206-0078 225 µM -1.21425352730187 0.165571446097318 no 2838 0.112325462984257 4311 5404595
SGTC_1885 st057546 99.9 µM -1.21517625345891 0.165385603523518 no 2839 0.112149437663302 4328 702008
SGTC_112 phenothiazine 287.218 µM -1.21610124262961 0.165199440675532 no 2840 0.111973178623322 4259 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_511 blebbistatin 171 µM -1.2166058317389 0.165097944524624 no 2841 0.111877111421908 4345 3476986 A myosin inhibitor.
SGTC_1036 k216-0215 33.5 µM -1.21852634476906 0.164712010048537 no 2842 0.111512009853733 4255 622330
SGTC_2478 5763493 32.33 µM -1.21906178965187 0.164604514618468 no 2843 0.111410370587266 4243 1365576 YLR208W SEC13
SGTC_307 1501-1223 22.3 µM -1.21940760002093 0.164535114208095 no 2844 0.111344763389814 4338 2830329
SGTC_977 1348-1378 135 µM -1.21951047437136 0.164514472096172 no 2845 0.111325251390219 4286 X977
SGTC_808 0711-0032 135 µM -1.22158012122997 0.164099546514973 no 2846 0.110933224900152 4282 4252555
SGTC_2333 9017922 200 µM -1.22324407201974 0.163766448123154 no 2847 0.110618762062994 4341 3163164
SGTC_2687 chenodiol 100 µM -1.22352576612568 0.163710100588765 no 2848 0.11056558921501 4369 5702181 A cholesterol synthesis inhibitor.
SGTC_1214 0358-0031 63.7 µM -1.22369229332674 0.163676795917616 no 2849 0.110534163999751 4367 4301366
SGTC_1383 3049-0032 20.7 µM -1.2248871881752 0.163437951491161 no 2850 0.110308864127731 4362 712864
SGTC_1410 3909-8106 77.9 µM -1.22804156989547 0.162808518511539 no 2851 0.109715681676342 4351 1039210
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.22992693604405 0.162433061685331 no 2852 0.109362233200752 4346 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_851 0394-0702 453 µM -1.23007192973441 0.162404210609371 no 2853 0.109335085227557 4314 762646
SGTC_2635 hydroquinidine 100 µM -1.23146653636619 0.162126879885777 no 2854 0.109074212481322 4233 442912 An experimental heart treatment.
SGTC_3070 9117005 49.47 µM -1.23676197624265 0.161076642075723 no 2855 0.108087731143596 4401 8779016
SGTC_3255 9139072 49.47 µM -1.23828099190631 0.160776198885867 no 2856 0.107805944663749 4318 17646060
SGTC_128 0906-2981 13.371 µM -1.24179126994424 0.160083308451214 no 2857 0.107156792293401 4303 6740226
SGTC_1455 4262-0120 131 µM -1.24255367987994 0.159933075545605 no 2858 0.107016173921933 4385 1529587
SGTC_889 0919-1524 82.7 µM -1.2431347932905 0.159818629074481 no 2859 0.10690908318188 4336 3905452
SGTC_2115 tiliquinol 12.7705 µM -1.2487372684432 0.158718007189181 no 2860 0.105880592485437 4305 71208 A bioactive hydroxyquinoline.
SGTC_2782 7736369 71.43 µM -1.24879146502544 0.158707384444787 no 2861 0.105870678235666 4339 2950836 YOL077C BRX1
SGTC_140 0062-0056 502.533 µM -1.24923041224128 0.158621366230807 no 2862 0.10579040578536 4238 3758964
SGTC_2040 5100729 123 µM -1.25072338479884 0.158329024986888 no 2863 0.105517707824496 4342 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2581 avocatin a 64 µM -1.25084031901383 0.158306142856408 no 2864 0.105496370766815 4281 6710728 A skin care supplement.
SGTC_224 benfluorex 43.875 µM -1.25103637700688 0.158267782354177 no 2865 0.105460602947377 4349 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1206 3978-0017 132 µM -1.25125849614262 0.158224330126115 no 2866 0.105420091264471 4395 3873677
SGTC_3326 9140064 16.379 µM -1.25148848231651 0.158179347152935 no 2867 0.105378156597582 4264 1868434
SGTC_3177 9107506 49.47 µM -1.25393909641092 0.1577005530191 no 2868 0.104932071554621 4283 8897194
SGTC_2679 rapamycin 1 nM -1.25526090213261 0.157442697961928 no 2869 0.104692031697417 4225 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1058 3448-5425 97.3 µM -1.25587467701158 0.157323058323029 no 2870 0.104580705517164 4277 7279705
SGTC_3221 9128209 49.47 µM -1.25635730776173 0.157229023847636 no 2871 0.104493226439876 4357 16460723
SGTC_1280 0880-0253 10.1 µM -1.25719550315665 0.157065799957323 no 2872 0.104341425621125 4304 6836607
SGTC_1369 1866-0067 208 µM -1.25865839090189 0.15678119524761 no 2873 0.104076873288772 4350 3531355
SGTC_645 0845-0943 5.41 µM -1.25933530376878 0.156649616820466 no 2874 0.103954623364726 4343 1885106
SGTC_720 r052-1644 49.9 µM -1.25989827441265 0.156540241882012 no 2875 0.103853030659733 4351 1422863 YOR257W CDC31
SGTC_121 0557-0495 61.343 µM -1.26178089664234 0.156174847978646 no 2876 0.103513819022679 4399 3104427
SGTC_2005 4024620 188 µM -1.26213855815928 0.156105493832981 no 2877 0.10344946642193 4301 236743
SGTC_2529 gangaleoidin 93.61 µM -1.26326790354022 0.155886635702768 no 2878 0.103246458458148 4349 4565183
SGTC_2489 cantharidin 73.42 µM -1.26553697088025 0.155447520321963 no 2879 0.102839452023099 4293 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_713 1488-1073 324 µM -1.26768642466011 0.155032306303326 no 2880 0.10245497731057 4359 3312542
SGTC_1420 4'-methoxyflavone 42 µM -1.26837046435156 0.154900322832098 no 2881 0.102332842021762 4325 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1901 st060216 58.6 µM -1.27024494043183 0.154539028560123 no 2882 0.101998697028582 4297 688792
SGTC_601 0986-0029 62.9 µM -1.27154463372867 0.154288847546725 no 2883 0.101767479645506 4285 24747981
SGTC_618 k072-0232 33.2 µM -1.27215966191883 0.154170552736273 no 2884 0.101658198307674 4390 5872756 YGL099W LSG1
SGTC_1731 st035964 63 µM -1.27372018187405 0.153870670882232 no 2885 0.10138130068166 4254 6739575
SGTC_360 0957-0399 1.01 µM -1.27467550929395 0.153687278244088 no 2886 0.101212059375189 4355 6752301 YPR165W RHO1
SGTC_82 0054-0107 293.755 µM -1.27483299009109 0.153657060813139 no 2887 0.101184180596002 4301 3104697
SGTC_1182 1222-0449 220 µM -1.2752711060373 0.153573015777825 no 2888 0.101106650499582 4342 658318
SGTC_1733 st037357 54.9 µM -1.27603848438336 0.153425880762859 no 2889 0.100970957651163 4255 1272339 YGL099W LSG1
SGTC_2064 5220758 200 µM -1.27793414901131 0.153062811604617 no 2890 0.100636323008453 4400 788518
SGTC_2206 7254556 146.969 µM -1.27875012854678 0.152906705741309 no 2891 0.100492530485459 4383 4398905
SGTC_2048 5246248 200 µM -1.28048582876268 0.152574998410564 no 2892 0.10018716277614 4362 677046
SGTC_750 4073-0104 132 µM -1.28222011322941 0.152244038840668 no 2893 0.0998827212533552 4060 22330957
SGTC_41 0478-0632 82.643 µM -1.28385239709347 0.151932980118814 no 2894 0.0995968029895134 4331 3750424
SGTC_2796 7949634 45.45 µM -1.28406683766757 0.151892146314539 no 2895 0.099559285096182 4323 2971588
SGTC_521 r062-0005 13.8 µM -1.28429781669041 0.151848171413457 no 2896 0.0995188852394117 4274 2832033
SGTC_1323 1348-1351 11.2 µM -1.28451130694644 0.151807533631357 no 2897 0.0994815549471782 4338 6989654
SGTC_3056 9094900 49.47 µM -1.28489693714581 0.151734147399352 no 2898 0.0994141507015291 4335 25236784
SGTC_425 3825-7017 13.1 µM -1.28626316354312 0.151474341414208 no 2899 0.0991756168468853 4391 3397440
SGTC_2247 cerulenin 830 nM -1.28646691233009 0.15143562125189 no 2900 0.0991400795855493 4399 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1807 st050092 58.9 µM -1.28716874215867 0.151302296780821 no 2901 0.0990177397896858 4369 5008496
SGTC_549 1661-1316 519 µM -1.28861342759346 0.151028100120199 no 2902 0.0987662564646033 4382 2857282
SGTC_2072 5231554 129 µM -1.28863636235033 0.151023749845061 no 2903 0.0987622678740091 4408 789545
SGTC_3179 9107801 49.47 µM -1.29032186311612 0.150704271538053 no 2904 0.0984694644889038 4356 4818259
SGTC_1304 1165-0502 251 µM -1.29563711153934 0.149699741676576 no 2905 0.097550268548585 4344 767425
SGTC_1438 4092-1045 4 µM -1.30738440065456 0.147495498810884 no 2906 0.0955410962750109 4378 1351342
SGTC_1864 st057645 30.4 µM -1.30905459835288 0.147183880215974 no 2907 0.0952579284620171 4411 688666
SGTC_2811 7967822 32.47 µM -1.30972079736108 0.147059706774457 no 2908 0.0951451526543114 4401 2232244
SGTC_2020 4017018 200 µM -1.3101547579705 0.146978858252848 no 2909 0.0950717436391807 4420 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1658 st012944 20 µM -1.31484146068557 0.146107607063149 no 2910 0.0942815950202145 4222 24207260
SGTC_2524 avocatin b 10.57 µM -1.31631504903178 0.14583438748982 no 2911 0.0940341609366088 4377 6710748
SGTC_3043 9092303 49.47 µM -1.31962881333224 0.14522123398985 no 2912 0.0934794889791135 4400 25236084
SGTC_1314 1222-0010 41.1 µM -1.31974384785092 0.145199980085489 no 2913 0.0934602775050616 4387 3526027
SGTC_2860 9025725 38.96 µM -1.32022091354362 0.145111859243691 no 2914 0.0933806357168133 4425 40546248
SGTC_649 1123-0311 367 µM -1.3213791597245 0.144898064442818 no 2915 0.0931874856631387 4299 693629 YIL048W NEO1
SGTC_1619 st003326 88.7 µM -1.32175192044997 0.144829303559175 no 2916 0.0931253866274861 4362 2849032
SGTC_646 4092-0839 27.3 µM -1.32368983792778 0.144472181898668 no 2917 0.0928030373944704 4408 877796
SGTC_1612 st002233 45.4 µM -1.32403373863815 0.144408869525994 no 2918 0.0927459199580546 4391 1035021
SGTC_1503 4585-0012 61.3 µM -1.3240698040663 0.144402230937686 no 2919 0.0927399314658747 4407 2922052
SGTC_2414 st077232 92.9 µM -1.32486769534168 0.144255415144709 no 2920 0.0926075185627852 4322 729801
SGTC_890 0929-0006 47.2 µM -1.326840400446 0.143892860075167 no 2921 0.0922807415106053 4371 1378169
SGTC_1590 st077108 57.8 µM -1.32930993214594 0.143439862425158 no 2922 0.0918728694070042 4398 5489485
SGTC_2511 berberine 10.47 µM -1.33638527837005 0.14214733445202 no 2923 0.090711687820668 4373 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2826 7992541 19.48 µM -1.33745711530112 0.14195222038143 no 2924 0.0905367358339391 4402 2985066
SGTC_1051 3253-3903 78 µM -1.33823437733177 0.141810843338773 no 2925 0.0904100229977951 4382 5509239
SGTC_2417 cerulenin 830 nM -1.33834029907543 0.141791584501963 no 2926 0.0903927653478291 4401 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1663 st014140 55.4 µM -1.34014736240511 0.141463294645522 no 2927 0.0900987203255789 4455 4207120
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.34300711044567 0.140944816473679 no 2928 0.089634835731829 4410 66535 A nucleotide analog.
SGTC_3153 9100258 49.47 µM -1.34313744196756 0.140921217852813 no 2929 0.0896137368241478 4312 25236848
SGTC_3267 9137951 49.47 µM -1.34813094048277 0.140019082829235 no 2930 0.0888081357545143 4441 16643986
SGTC_2017 5132927 60.65 µM -1.35243729578401 0.139244246350635 no 2931 0.0881177326125646 4390 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3102 9121669 49.47 µM -1.35399016514341 0.138965557863402 no 2932 0.0878697577083612 4445 41905072
SGTC_758 0868-0029 16 µM -1.35677172292555 0.13846731049429 no 2933 0.0874268774714368 4390 762687
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.36420239843945 0.137142263993026 no 2934 0.0862519367752671 4426 390807
SGTC_71 0417-1750 47.813 µM -1.36978063023577 0.136153257389456 no 2935 0.085377695133284 4383 6811472
SGTC_3272 9137413 49.47 µM -1.37149124494137 0.13585095005615 no 2936 0.0851109354477102 4339 17614870
SGTC_569 4130-2812 160 µM -1.37298137879369 0.135587981930579 no 2937 0.084879067845332 4274 743552
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -1.37466301422867 0.135291638084279 no 2938 0.0846179713821897 4419 5377381
SGTC_1602 st001878 87.6 µM -1.37726349388397 0.134834246924328 no 2939 0.0842153987754364 4406 595405 YLR310C CDC25
SGTC_2258 7960471 200 µM -1.37749803322527 0.134793046668216 no 2940 0.0841791612235708 4419 2974708
SGTC_1789 tunicamycin 25 nM -1.37907454855308 0.134516332929135 no 2941 0.0839358850750542 4329 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_586 0957-0265 8.15 µM -1.38025151414636 0.134310003520792 no 2942 0.0837546089623992 4304 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2520 obtusaquinone 4.71 µM -1.38769553296553 0.133010055637544 no 2943 0.0826148884244214 4464 5967872
SGTC_2965 9082772 38.63 µM -1.39151119491863 0.132347095616538 no 2944 0.0820352336446978 4435 16459634
SGTC_1378 2093-0007 380 nM -1.39164345982382 0.132324155892147 no 2945 0.0820151957641895 4469 3618014
SGTC_1488 4013-0813 75.9 µM -1.3944091730934 0.131845104611377 no 2946 0.0815970398130683 4407 2910057
SGTC_1241 0364-0022 50.8 µM -1.39508225718604 0.131728700450888 no 2947 0.0814955179724905 4425 4563895
SGTC_3052 9092717 49.47 µM -1.39667276562146 0.131453917394995 no 2948 0.0812559987754847 4440 25237534
SGTC_2646 retinol 96.75 µM -1.39882628287859 0.131082497512725 no 2949 0.0809325413488863 4428 445354 A vitamin A analog and teratogen.
SGTC_2884 9058502 51.95 µM -1.40089009598906 0.130727229928371 no 2950 0.0806234704375535 4440 6471554
SGTC_626 0214-0009 33 µM -1.40183937872934 0.130564042803291 no 2951 0.0804816081716271 4492 3437874
SGTC_1819 st053448 58.6 µM -1.40374740609222 0.130236468236193 no 2952 0.080197040195836 4360 2857616
SGTC_2655 perillic acid 100 µM -1.4039095990989 0.130208648810837 no 2953 0.0801728854406988 4493 5702197 An apoptosis inducer.
SGTC_1275 0867-0008 21.1 µM -1.41096747072895 0.12900206006817 no 2954 0.0791271029238762 4415 3422836
SGTC_1830 st055982 50.3 µM -1.41230396168349 0.128774454256257 no 2955 0.0789302402082962 4436 455313 An antimicrobial agent.
SGTC_874 0599-0792 117 µM -1.41424715943571 0.128444022892039 no 2956 0.0786446728478971 4444 765305
SGTC_1670 st016595 4.04 µM -1.41822085059072 0.127770149544595 no 2957 0.0780631481442436 4471 597879
SGTC_2513 baicalein 25.65 µM -1.41974362674048 0.127512563888466 no 2958 0.077841166070395 4440 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_278 4092-0821 23.9 µM -1.42125285890686 0.127257625774207 no 2959 0.0776216313859214 4451 877900
SGTC_1778 st046819 58.9 µM -1.42297092694292 0.126967843127461 no 2960 0.0773722916972772 4492 671715
SGTC_3181 9108277 49.47 µM -1.42403920659104 0.126787890568587 no 2961 0.0772175614893825 4416 17097298
SGTC_2304 7443016 91.4 µM -1.42647700253493 0.126377907106125 no 2962 0.0768653502884737 4400 939854
SGTC_2752 diclazuril 33.15 µM -1.43437391785965 0.12505616677662 no 2963 0.0757327932928131 4382 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1376 2910-0861 41.3 µM -1.43719829071358 0.12458579193544 no 2964 0.0753308292771632 4409 1112859
SGTC_2917 7979103 53.79 µM -1.43950381034191 0.124202745521368 no 2965 0.075003915585382 4456 2980565
SGTC_2153 5569715 200 µM -1.44010519704931 0.124102964826372 no 2966 0.0749188194904887 4473 2054701
SGTC_40 0327-0103 19.753 µM -1.44221365011866 0.123753578227151 no 2967 0.0746210554866628 4308 409036
SGTC_2943 9068529 45.32 µM -1.44299538817982 0.123624213485116 no 2968 0.0745108851900935 4422 3270634
SGTC_33 0986-0033 35.816 µM -1.44342993549207 0.123552344043833 no 2969 0.0744496981802577 4433 2848082
SGTC_1018 4259-0013 28.1 µM -1.45179967082846 0.122173787004224 no 2970 0.0732786577398272 4506 6801262
SGTC_1927 st060202 13.8 µM -1.45315508443379 0.121951560427591 no 2971 0.0730903498724263 4394 688887
SGTC_1902 st060212 70.5 µM -1.4588732280348 0.121017169250344 no 2972 0.0723000014672352 4471 688944
SGTC_1136 pergolide 1.05886 µM -1.45961917946178 0.120895647130948 no 2973 0.0721973825557511 4410 47811 A dopamine receptor agonist.
SGTC_51 1013-0126 23.419 µM -1.46103627753999 0.120665025836751 no 2974 0.0720027429881523 4461 1627850
SGTC_2305 7443522 69.23 µM -1.46650025971925 0.119778706744593 no 2975 0.0712560252480192 4367 5415886
SGTC_2773 thioridazine 9.09 µM -1.46753452816589 0.119611454858053 no 2976 0.0711153518127793 4454 5452 An antipsychotic.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.47251237827668 0.118808789516051 no 2977 0.0704412834318965 4461 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1740 st038286 13.222 µM -1.4760657951406 0.11823814259208 no 2978 0.0699631150924545 4489 716786
SGTC_659 k018-0002 107 µM -1.47811975418502 0.117909180391904 no 2979 0.0696878637664862 4451 6797879 YHR007C ERG11
SGTC_3122 9126309 49.47 µM -1.47845932650415 0.117854856905913 no 2980 0.0696424380480127 4583 17591206
SGTC_3222 9128301 49.47 µM -1.48282835767773 0.11715749526935 no 2981 0.0690600098657205 4448 4911358
SGTC_3150 9097574 49.47 µM -1.48311383414552 0.117112030987757 no 2982 0.0690220845277652 4519 17217476
SGTC_2300 7976697 71.57 µM -1.48410123997649 0.116954875551789 no 2983 0.0688910321616366 4374 2236109
SGTC_1052 3253-3998 198 µM -1.48494616652734 0.116820515820229 no 2984 0.0687790425749069 4435 5450317
SGTC_138 0850-0259 40.9225 µM -1.48644227709561 0.116582873661968 no 2985 0.068581087129117 4428 6813004
SGTC_2969 9091408 28.7 µM -1.48865416673716 0.116232165602049 no 2986 0.0682892300205251 4411 4286311
SGTC_145 3737-0113 38.366 µM -1.48888288243531 0.116195944142629 no 2987 0.0682591059255503 4472 6849351
SGTC_529 4076-0302 30.3 µM -1.4897318807662 0.116061559247304 no 2988 0.0681473742229156 4449 5816522
SGTC_678 1218-2179 85.9 µM -1.49253141310012 0.115619213122577 no 2989 0.0677799442573143 4529 6820081 YOR116C RPO31
SGTC_1628 st004252 77.7 µM -1.49513792714291 0.115208443126646 no 2990 0.0674392246761369 4487 692968
SGTC_2733 amorolfine 100 µM -1.4971387518224 0.114893830550258 no 2991 0.067178579130341 4650 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_831 k061-1017 217 µM -1.49736030534893 0.114859030770222 no 2992 0.0671497655271404 4538 1240153
SGTC_1673 st016611 27.3 µM -1.50074085078317 0.114328972710642 no 2993 0.0667113013609601 4490 5226799
SGTC_1780 st038448 24.544 µM -1.50699014578732 0.11335369512193 no 2994 0.0659065915426407 4510 728868 YDL195W SEC31
SGTC_1569 carminic acid 40.6 µM -1.50704204280567 0.113345620889462 no 2995 0.0658999404972003 4574 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2283 7944793 200 µM -1.51165361675381 0.11262978091105 no 2996 0.0653110020573139 4487 2970533
SGTC_1373 2887-0003 58.5 µM -1.51511088652174 0.112095241627679 no 2997 0.0648721625927751 4461 776948
SGTC_751 0833-0568 350 µM -1.51568255974306 0.112007028464883 no 2998 0.0647998198307501 4506 6954252
SGTC_617 3770-0098 35 µM -1.5171254354868 0.111784603432508 no 2999 0.0646175087463477 4427 5962639
SGTC_701 4424-0219 185 µM -1.51725089964201 0.111765277574468 no 3000 0.0646016748718335 4520 2911779
SGTC_2890 9046729 58.44 µM -1.51926412534025 0.111455497357875 no 3001 0.0643480129688347 4487 903329
SGTC_927 2425-1185 123 µM -1.52030632975815 0.111295372290765 no 3002 0.0642170019623541 4461 730375
SGTC_491 tetrandrine 80.3 µM -1.52076768491733 0.111224541949689 no 3003 0.064159073245215 4520 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2954 9074818 52.69 µM -1.52077532468578 0.111223369312856 no 3004 0.0641581143219496 4510 16648742
SGTC_3099 9120367 49.47 µM -1.52082628072353 0.111215548238515 no 3005 0.0641517187415947 4537 24824940
SGTC_209 4077-0173 175.592 µM -1.52648271433913 0.110349807328825 no 3006 0.0634448460480442 4482 15993494
SGTC_1321 1326-2144 215 µM -1.52717744467132 0.110243810070059 no 3007 0.0633584466933684 4479 3513030
SGTC_1558 st069300 45.6 µM -1.52872078328341 0.110008599237765 no 3008 0.0631668388826284 4464 24208000
SGTC_2131 toluylene red 5.2905 µM -1.53066455264813 0.109712873801496 no 3009 0.0629261593792449 4465 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_554 4483-2211 187 µM -1.53589019374273 0.108920674358596 no 3010 0.0622826568103091 4559 747107
SGTC_2576 guaiol 23.12 µM -1.53910902870823 0.108434754979672 no 3011 0.0618888406156425 4414 227829
SGTC_1594 piperine 70.1 µM -1.53965853697982 0.108351956626467 no 3012 0.0618218043269351 4514 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_120 rhodamine 6G 52.259 µM -1.53984203485383 0.10832431782085 no 3013 0.0617994314566041 4517 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_560 2332-1943 155 µM -1.54056191244426 0.108215937457725 no 3014 0.061711721833502 4509 21177716
SGTC_782 0083-0095 30.5 µM -1.54417685493118 0.107672873828161 no 3015 0.0612727471316602 4485 3591729 An indicator and reagent.
SGTC_2924 9010168 62.78 µM -1.54442282998826 0.107635993094937 no 3016 0.0612429664294954 4518 2993929
SGTC_2236 dapsone 200 µM -1.54722933810404 0.107215838267184 no 3017 0.060903976938145 4546 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1694 st024011 44.9 µM -1.54790391216521 0.107115026105676 no 3018 0.0608227163007163 4564 2787533
SGTC_829 1635-0120 117 µM -1.54887810277519 0.10696955822891 no 3019 0.0607055128700419 4502 285054
SGTC_2355 9061122 103.12 µM -1.55013316733745 0.106782359886336 no 3020 0.060554778372243 4533 5302957
SGTC_2301 7769476 200 µM -1.55127083288071 0.106612876481948 no 3021 0.0604183967681783 4504 977820
SGTC_37 0566-0070 1.56 µM -1.55473686692602 0.106097722138091 no 3022 0.0600043752339724 4441 1626686
SGTC_2964 9083345 53.42 µM -1.55559576916927 0.105970342570576 no 3023 0.0599021227094271 4490 17741579
SGTC_3273 9137859 49.47 µM -1.55648804786948 0.105838130180559 no 3024 0.05979604129803 4599 2377234
SGTC_3291 9121177 71.43 µM -1.55706826286833 0.105752221473869 no 3025 0.0597271395811066 4505 17015612
SGTC_2378 9074213 121.43 µM -1.55719540090878 0.105733403696194 no 3026 0.0597120499907518 4499 657714
SGTC_1245 0418-0076 17.2 µM -1.56152536860724 0.105093967021006 no 3027 0.0591999215054537 4537 6790114
SGTC_478 N-arachidonylglycine 10 µM -1.56154588528172 0.105090943856727 no 3028 0.0591975031139423 4563 5283389
SGTC_1896 st058441 89 µM -1.5680373836024 0.104137569320319 no 3029 0.0584362040797301 4545 688759
SGTC_540 1187-0821 17.3 µM -1.57047576160088 0.103781081534219 no 3030 0.0581522345120627 4454 847520
SGTC_408 cantharidin 100 µM -1.57183503280065 0.103582742502872 no 3031 0.0579944072919093 4517 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_541 4513-1321 94 µM -1.57279038779893 0.103443505892 no 3032 0.0578836810472596 4500 747515
SGTC_1029 k015-0030 64.7 µM -1.57342583119368 0.103350969522515 no 3033 0.0578101248322317 4541 2208316
SGTC_268 camptothecin 39.6153 µM -1.57396665826341 0.103272258995275 no 3034 0.0577475789046678 4488 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2611 pyromycin 23.93 µM -1.57541815229524 0.103061227606497 no 3035 0.0575799785703481 4483 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1675 st018485 24.5 µM -1.58195201748463 0.102115152941696 no 3036 0.0568302623347829 4531 3323024
SGTC_997 3996-0078 137 µM -1.58549017055963 0.101605488881812 no 3037 0.0564275042316388 4586 735687
SGTC_1212 0520-0165 585 µM -1.58581624716956 0.101558611569665 no 3038 0.0563904995003313 4577 5403258
SGTC_1367 1812-0510 76.9 µM -1.588472636796 0.101177311294924 no 3039 0.0560897519017377 4591 1142582 YDR527W RBA50
SGTC_148 3253-0744 288.01 µM -1.59026790920258 0.100920207918225 no 3040 0.0558872144558653 4428 6893655
SGTC_1217 1183-1422 255 µM -1.59201675438734 0.100670211764608 no 3041 0.0556904700101676 4575 2849664
SGTC_1564 D-Arginine 115 µM -1.5932377432082 0.100495940259708 no 3042 0.0555534335389358 4536 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1526 st051518 75 µM -1.59535343419164 0.100194489401385 no 3043 0.0553166114246892 4527 673993
SGTC_219 mitoxanthrone 164.414 µM -1.60211070494373 0.0992361120976513 no 3044 0.0545655656027283 4499 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1605 st000082 49.1 µM -1.60280083697442 0.0991386098708113 no 3045 0.0544893160021556 4503 1114022
SGTC_2368 9071271 200 µM -1.60497406653594 0.0988320325314132 no 3046 0.0542497560004217 4531 27209959
SGTC_3147 9097027 49.47 µM -1.60563953790516 0.0987382934147133 no 3047 0.0541765664873456 4552 25236841
SGTC_891 0929-0073 133 µM -1.60740709866455 0.0984896285965411 no 3048 0.0539825469504631 4562 5603632
SGTC_1100 amiodarone 5.07 µM -1.60765458844062 0.0984548477499312 no 3049 0.0539554247380958 4578 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_684 1140-0066 328 µM -1.61276264779734 0.0977389964771822 no 3050 0.053398042003925 4554 6813534
SGTC_130 0136-0219 337.655 µM -1.62315850849906 0.0962939041721819 no 3051 0.0522777624531709 4458 234244
SGTC_2748 diazoxide 86.69 µM -1.6277106164858 0.0956660987773553 no 3052 0.0517931304607008 4635 3019 A potassium channel activatior.
SGTC_946 3434-1334 87.4 µM -1.63288963180745 0.094955501557446 no 3053 0.0512461055745645 4530 4047976
SGTC_1685 st024049 53.0905 µM -1.63810298243637 0.0942441281677023 no 3054 0.0507001064779583 4584 1941139
SGTC_3027 9089541 49.47 µM -1.63941121443861 0.0940662355371393 no 3055 0.0505638238247801 4556 9943819
SGTC_2938 9059746 27.26 µM -1.63953105906585 0.0940499515301437 no 3056 0.0505513538368152 4542 6471769
SGTC_999 SEC7.066 22.7 µM -1.64158750214412 0.0937708542782442 no 3057 0.0503377597343342 4517 740511 YDR170C SEC7
SGTC_756 0508-1999 28.3 µM -1.64248008345583 0.0936499049961491 no 3058 0.0502452751800536 4588 6753853
SGTC_582 0987-0078 156 µM -1.6451827705204 0.0932843797219967 no 3059 0.0499660627553782 4605 1625765
SGTC_2348 9022543 33.42 µM -1.64751762647248 0.0929694513922156 no 3060 0.0497258481183269 4581 3162678 YDL140C RPO21
SGTC_246 cycloheximide 667 µM -1.64829023660732 0.0928654140210631 no 3061 0.0496465636385925 4510 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1146 3579-1023 7 µM -1.6501651848191 0.0926132970663881 no 3062 0.0494545777225337 4593 X1146
SGTC_1656 st012921 11 µM -1.65113934647444 0.0924825053929287 no 3063 0.0493550623286702 4489 6732821
SGTC_2821 7996764 71.43 µM -1.65369715589877 0.0921397425473656 no 3064 0.0490945304111825 4546 2987135
SGTC_3328 9140624 29.0385 µM -1.65637745018722 0.0917815759965322 no 3065 0.0488227023803537 4559 4904392
SGTC_1878 temozolomide 1 mM -1.65790682424086 0.0915776691035587 no 3066 0.0486681372719927 4548 5394 DNA alkylating agent.
SGTC_2459 5811157 9.22 µM -1.66540810589506 0.0905824049939503 no 3067 0.0479156816638939 4529 2870684 YBR192W RIM2
SGTC_523 1934-0222 13.7 µM -1.66632964341214 0.0904606920580443 no 3068 0.0478238877989084 4543 1361595
SGTC_2253 7938677 135.83 µM -1.67067034516834 0.0898890224611583 no 3069 0.0473934047013272 4607 2301972
SGTC_3329 9141233 27.5565 µM -1.67468117454277 0.0893631876900118 no 3070 0.0469984014885394 4541 4909101 YNL103W MET4
SGTC_1587 estradiol valerate 56.1 µM -1.6770598861681 0.0890524125634189 no 3071 0.0467653859449285 4629 13791 A steroid.
SGTC_54 0159-0055 9 µM -1.68038692952178 0.0886190896947628 no 3072 0.04644102871429 4557 3319099
SGTC_928 2764-0428 58.7 µM -1.68200926337541 0.0884083631711977 no 3073 0.0462835218265155 4597 662578
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.68253068135171 0.0883407150305739 no 3074 0.0462329903047227 4597 23665772 A membrane-active detergent.
SGTC_2442 5158906 48.48 µM -1.68385578901758 0.0881689707504259 no 3075 0.0461047711610698 4574 1893835
SGTC_1908 st060353 56.5 µM -1.68696876747061 0.0877664838435092 no 3076 0.0458046788337712 4574 4227716
SGTC_248 streptozotocin 5.23457 mM -1.68790215934859 0.0876460701259792 no 3077 0.0457150060378841 4616 5300 DNA alkylating agent.
SGTC_13 0199-0087 65 µM -1.68901035579191 0.0875032655666731 no 3078 0.0456087227090623 4677 4589825
SGTC_744 1594-0068 283 µM -1.69008798706054 0.0873645662995728 no 3079 0.0455055613869775 4574 668392
SGTC_1426 4048-4480 71.7 µM -1.69814622190377 0.0863326086379482 no 3080 0.0447400837860401 4601 14224343
SGTC_1152 3909-8331 15.9 µM -1.69942209205805 0.0861700568939475 no 3081 0.0446198411717519 4590 16001939
SGTC_295 k015-0027 31 µM -1.70126826331796 0.0859352516298662 no 3082 0.0444463122887785 4638 3887424
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.70187016093396 0.0858588028811082 no 3083 0.0443898552506764 4654 688664
SGTC_1116 jasmonic acid 1.58368 µM -1.7053500820013 0.085417805687363 no 3084 0.0440645761469858 4626 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_456 gingerol 170 µM -1.70593738314455 0.0853435468681374 no 3085 0.0440098692968744 4594 442793 A herb.
SGTC_497 capsazepine 133 µM -1.7080920925228 0.0850715178835107 no 3086 0.043809627961973 4547 2733484 A calcium channel blocker.
SGTC_1812 st052057 4.327 µM -1.70829563077038 0.0850458551005066 no 3087 0.0437907508105442 4604 3645418
SGTC_119 0121-0043 24.815 µM -1.708526518732 0.0850167509986272 no 3088 0.0437693450547304 4595 1092378
SGTC_237 nikkomycin 200 µM -1.71124067897059 0.0846751826621397 no 3089 0.0435183460493262 4607 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1015 4130-4525 82 µM -1.71352228818911 0.0843888465775192 no 3090 0.0433082482814178 4593 1363237
SGTC_2598 perillyl alcohol 100 µM -1.71368972229267 0.0843678626778992 no 3091 0.043292862734441 4593 10819 An apoptosis inducer.
SGTC_314 1671-0008 2.74 µM -1.71579328398163 0.0841045645415602 no 3092 0.0430999419150174 4466 3913060
SGTC_1260 0700-1617 7.75 µM -1.71659310856153 0.0840046143080053 no 3093 0.0430267712635975 4566 2853078
SGTC_675 1309-0189 238 µM -1.71738019334171 0.0839063431995542 no 3094 0.0429548640990558 4600 4246530
SGTC_1821 st053465 65.6 µM -1.72232923940533 0.0832904095305065 no 3095 0.0425049469445259 4622 675086
SGTC_16 erodoxin 22.806 µM -1.72233274546181 0.0832899743922857 no 3096 0.0425046295655346 4646 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1461 k072-0203 53.8 µM -1.72469086738656 0.0829976938095788 no 3097 0.0422915988762406 4482 5418714
SGTC_2619 obliquin 87.91 µM -1.72814775519685 0.0825706205778994 no 3098 0.0419808687978378 4589 6708593 A bioactive alkalod. YER133W GLC7
SGTC_505 gw-5074 63.9 µM -1.7303250930937 0.0823024767194476 no 3099 0.0417861043602446 4594 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_711 k292-0785 179 µM -1.73079880745536 0.0822442247269195 no 3100 0.0417438273400308 4547 4146315
SGTC_558 k064-0027 21.3 µM -1.73516212995682 0.0817091325276095 no 3101 0.0413560460515545 4606 5088526
SGTC_1947 st076332 61.6 µM -1.73535436638235 0.0816856182865413 no 3102 0.041339028812821 4467 24208416
SGTC_596 1155-0152 116 µM -1.73820930665197 0.08133700396902 no 3103 0.0410869699158577 4626 280313
SGTC_2101 5377231 179.231 µM -1.74474556477572 0.0805430947279678 no 3104 0.0405145840331065 4620 2844213
SGTC_1322 1348-1070 12 µM -1.74704227729579 0.0802655248414382 no 3105 0.0403150024350476 4616 6758089
SGTC_1617 st002906 78 µM -1.75103102924652 0.0797851819223425 no 3106 0.0399702826425903 4594 5150859
SGTC_1306 1185-0270 9.02 µM -1.75821176068301 0.0789259319806243 no 3107 0.0393557424455088 4617 1548076
SGTC_1017 4239-0030 168 µM -1.76224237990211 0.0784467075636809 no 3108 0.0390141772693972 4627 1149593
SGTC_1626 st003712 1.76 µM -1.76424890635896 0.0782089636180863 no 3109 0.03884504102047 4610 24207035
SGTC_2551 apiole 73.87 µM -1.77437285886827 0.0770177513824351 no 3110 0.0380007481003368 4561 10659 A possible DNA adduct former.
SGTC_3005 9076496 71.4286 µM -1.77647071435872 0.076772645732718 no 3111 0.0378276823627859 4576 21368410
SGTC_3311 9131146 2.8755 µM -1.77667608559 0.0767486828296163 no 3112 0.0378107745776705 4581 4900406 YPR165W RHO1
SGTC_2514 salinomycin 42.74 µM -1.78642281231671 0.0756179539294566 no 3113 0.0370154123529555 4619 23682228 A polyether potassium ionophore.
SGTC_3123 9126162 49.47 µM -1.78680615627305 0.0755737425703265 no 3114 0.0369844120038161 4605 25239884
SGTC_3017 9080681 49.47 µM -1.78713870770287 0.0755354051093498 no 3115 0.0369575363513263 4645 16451914
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.79090411663308 0.0751023514818189 no 3116 0.0366543414891899 4625 688751
SGTC_1356 1502-0781 85.8 µM -1.79316574432957 0.0748431569177644 no 3117 0.0364732128677154 4636 567702
SGTC_1546 5-methoxyflavanone 78.7 µM -1.79525410940186 0.0746044257218449 no 3118 0.0363066114872166 4650 147795
SGTC_263 alizarin 107.927 µM -1.79667303084652 0.0744425537827643 no 3119 0.0361937714295862 4651 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_3089 9117425 49.47 µM -1.7986701214227 0.0742151782102676 no 3120 0.0360354389729459 4594 9401657
SGTC_3292 9120825 59.784 µM -1.80352277429241 0.0736648977105784 no 3121 0.0356530760265075 4604 24824900
SGTC_3168 9103419 49.47 µM -1.80413238272031 0.0735959905265857 no 3122 0.0356052781427924 4676 16649256
SGTC_2698 st077697 67.5 µM -1.80740881573017 0.0732264823705679 no 3123 0.0353492802118597 4597 3154499
SGTC_1355 1499-0035 1.68 µM -1.8076454012381 0.0731998558762544 no 3124 0.0353308536344575 4631 1548538
SGTC_2228 7354201 200 µM -1.81302987447352 0.0725958616590501 no 3125 0.0349136068731934 4703 753451
SGTC_2294 7971431 200 µM -1.81372263357096 0.072518430525455 no 3126 0.0348602193479371 4614 5741572
SGTC_2996 9066192 71.4286 µM -1.81413746223203 0.0724720945511694 no 3127 0.0348282826439375 4598 6472854
SGTC_334 1502-1024 68.5 µM -1.81982086986154 0.071839545105722 no 3128 0.0343931442245814 4639 3296216
SGTC_330 1488-0319 80.1 µM -1.83017621174217 0.0706979179536795 no 3129 0.0336117968503204 4658 6846614
SGTC_2149 5554786 194.827 µM -1.83031574186597 0.0706826311720264 no 3130 0.0336013693996116 4666 745063 YPR165W RHO1
SGTC_236 1509-0011 5.31 µM -1.83173955784834 0.0705267844870269 no 3131 0.0334951160433114 4638 3107280
SGTC_680 0417-1641 114 µM -1.83375499227393 0.0703066327429093 no 3132 0.0333451857273508 4659 2835990
SGTC_951 1171-0579 82.7 µM -1.83568241327542 0.0700965896685451 no 3133 0.0332023202323048 4561 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1822 st052468 42 µM -1.83963559434103 0.0696672976507899 no 3134 0.0329108774864636 4660 2873678
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.84367918573136 0.0692302844981697 no 3135 0.0326149540799286 4630 688798
SGTC_327 1273-0057 3.96 µM -1.84480964033342 0.0691084885990965 no 3136 0.0325326172924164 4574 3108138
SGTC_506 n9-isopropylolomoucine 153 µM -1.85232448976894 0.0683030270051092 no 3137 0.0319896205480166 4649 6610355
SGTC_3075 9116269 49.47 µM -1.85387294837909 0.0681379628314021 no 3138 0.0318786694496813 4627 17015205 YNL244C SUI1
SGTC_2164 5685496 200 µM -1.85710532534557 0.0677943870595679 no 3139 0.0316480853599706 4591 759046
SGTC_312 4092-0653 6.84 µM -1.86105722443746 0.0673761516859221 no 3140 0.0313680480072368 4547 1148278
SGTC_1931 st074438 57.1 µM -1.86110650691129 0.0673709486672383 no 3141 0.0313645687559296 4646 2787313
SGTC_193 1273-0060 1.558 µM -1.86563954016828 0.0668936984577042 no 3142 0.0310459068583428 4536 2847393 YHR072W ERG7
SGTC_1295 1013-0063 9.78 µM -1.86649969483601 0.0668034349523117 no 3143 0.0309857433584771 4663 6826038
SGTC_2769 toremifene 3.73 µM -1.86874869831565 0.0665678727921836 no 3144 0.030828892654871 4638 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_341 1486-1430 230 µM -1.87478715878075 0.0659385808020548 no 3145 0.0304110052417108 4617 2054753 YPL210C SRP72
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.87535347838241 0.0658797996265156 no 3146 0.0303720553599481 4537 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_410 α-linolenic acid 100 µM -1.87932988555453 0.0654682111889838 no 3147 0.030099731721964 4673 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2263 7948595 193.29 µM -1.88060327691416 0.0653368279128775 no 3148 0.0300129528269568 4664 2971371
SGTC_1660 st012960 28.1 µM -1.88209703525425 0.0651829688709537 no 3149 0.0299114209206453 4677 24207266
SGTC_2981 9013952 38.96 µM -1.88990423550976 0.0643833874680439 no 3150 0.0293853844958756 4584 2996344
SGTC_1077 5-fluorocytosine 377 nM -1.89195724276401 0.0641743976446697 no 3151 0.0292483389476311 4685 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3240 9133527 49.47 µM -1.89298774925214 0.0640696942217994 no 3152 0.0291797493281778 4653 17617455
SGTC_1466 k213-0079 57.5 µM -1.89433746955394 0.0639327584029404 no 3153 0.0290901152763886 4663 3657981
SGTC_1962 st076595 64.5 µM -1.90087780889975 0.06327242969482 no 3154 0.0286590096826807 4620 279619
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.90235110273995 0.0631244176861984 no 3155 0.0285626344915715 4639 688761
SGTC_1407 3909-7909 12.3 µM -1.90720003707801 0.0626391811837332 no 3156 0.0282473443524866 4675 4411780
SGTC_2150 5556613 200 µM -1.90975775708101 0.0623844020911166 no 3157 0.0280822053012877 4678 743190
SGTC_3353 9151644 39.2805 µM -1.91903352351479 0.0614672008470868 no 3158 0.027490045694237 4662 4909158
SGTC_2232 chlorophetanol 41.5365 µM -1.92902868014587 0.060490691049503 no 3159 0.0268636509269273 4725 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2049 5262831 67.185 µM -1.9305037336177 0.0603476143876395 no 3160 0.0267722265245423 4636 763417
SGTC_514 4466-0038 2.65 nM -1.93856322759607 0.0595705345567113 no 3161 0.026277272416648 4491 5722064
SGTC_591 4299-0174 154 µM -1.94061690464976 0.0593737823359025 no 3162 0.0261523810503287 4712 5509088
SGTC_97 0535-0701 19.132 µM -1.9451610362757 0.0589402434721853 no 3163 0.0258777998564778 4584 2832013 YGL099W LSG1
SGTC_123 0083-0120 66.675 µM -1.94861616538685 0.0586122676227039 no 3164 0.0256706400831005 4649 16001701
SGTC_843 0310-0051 143 µM -1.9494904916407 0.0585295003535606 no 3165 0.0256184386101772 4692 2065037
SGTC_3319 9138450 16.7555 µM -1.96084435619431 0.0574630114766675 no 3166 0.0249485909896512 4640 2029690
SGTC_1293 1000-1278 195 µM -1.96653729563517 0.0569340486118391 no 3167 0.0246182892876886 4687 678847
SGTC_413 propylparaben 100 µM -1.97000294189013 0.0566139182800097 no 3168 0.0244190166992602 4666 7175 A pharmaceutical preservative.
SGTC_916 4466-0038 42 nM -1.97613748933327 0.0560507336935341 no 3169 0.0240696037168685 4699 5722064 YGL116W CDC20
SGTC_715 0868-0130 184 µM -1.97766303191523 0.0559113689394171 no 3170 0.0239833666715193 4714 2876258
SGTC_1310 1188-0297 994 nM -1.97791384161802 0.0558884826022562 no 3171 0.0239692135893785 4586 1588352
SGTC_1870 st057514 26.5 µM -1.97870939462845 0.0558159374406483 no 3172 0.0239243673113544 4676 5393161
SGTC_1932 st074806 40.9 µM -1.98142474307448 0.0555688887560339 no 3173 0.0237718306254082 4682 17251235
SGTC_1450 4112-4260 37.6 µM -1.98528005053401 0.0552196076654541 no 3174 0.0235566611538247 4670 1633175
SGTC_3166 9102297 49.47 µM -1.98593141332391 0.0551607674551577 no 3175 0.0235204700540723 4683 25237072
SGTC_1794 st048918 76.9 µM -1.98696651631369 0.0550673643593445 no 3176 0.0234630537640601 4672 672303
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.98852378286244 0.0549270790055275 no 3177 0.0233768956859862 4753 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2338 7999974 200 µM -1.99137264330964 0.0546711723337706 no 3178 0.0232199672511174 4648 315925
SGTC_1046 2001-0062 216 µM -1.99176845125633 0.0546356925082156 no 3179 0.0231982346394495 4642 739778
SGTC_1238 0333-0287 48.8 µM -2.01571560951822 0.0525227593076363 no 3180 0.0219148612055523 4705 7226
SGTC_2899 9053889 58.44 µM -2.02438376507829 0.0517741241020467 no 3181 0.021465340439669 4702 6470052
SGTC_571 k831-0106 44.2 µM -2.02702855628896 0.0515474001152623 no 3182 0.0213297461788293 4610 4783639
SGTC_988 1497-1057 103 µM -2.03255401128908 0.0510762798735512 no 3183 0.021048800880105 4685 3533044
SGTC_958 1222-0007 33 µM -2.03476090022588 0.0508890728858336 no 3184 0.0209374685312894 4709 7312461
SGTC_1910 st062352 60.4 µM -2.04001571845667 0.0504455134534219 no 3185 0.020674380098099 4627 2245730
SGTC_101 0490-5701 117.494 µM -2.04599771755776 0.0499443278975146 no 3186 0.0203782976184175 4599 4661669
SGTC_201 4262-0159 12.803 µM -2.04778735061719 0.0497951625376315 no 3187 0.020290420166462 4732 1341029
SGTC_1782 st039423 80.636 µM -2.05181959814327 0.0494603783566129 no 3188 0.0200935989684523 4690 2068169
SGTC_981 1488-1094 54.9 µM -2.0542051636493 0.0492631601800423 no 3189 0.0199779194268557 4674 3449522
SGTC_2706 st078239 82.5 µM -2.06353266694863 0.0484980624266601 no 3190 0.0195310237144529 4683 15434492
SGTC_566 0958-0068 16.5 µM -2.06615090749516 0.0482850151785586 no 3191 0.0194071163259205 4632 6815365
SGTC_1578 josamycin 24.2 µM -2.06900286177258 0.0480538031490186 no 3192 0.0192729090769346 4699 5282165 A P450 substrate.
SGTC_304 1310-0298 97 µM -2.07071752849989 0.0479152197042991 no 3193 0.0191926005930249 4461 1550234
SGTC_2895 9054447 58.44 µM -2.07127426141114 0.0478702920918113 no 3194 0.0191665865860512 4736 2697450
SGTC_2261 9010538 184.68 µM -2.07299651974197 0.0477315216179533 no 3195 0.019086301728712 4675 6457250
SGTC_3190 9110366 49.47 µM -2.07367887732314 0.0476766300275849 no 3196 0.0190545721046426 4696 17123768
SGTC_3116 9124943 49.47 µM -2.07393571716026 0.0476559818976106 no 3197 0.019042640678022 4684 41905195 YPL160W CDC60
SGTC_2334 9017922 200 µM -2.08193760670524 0.0470162655411533 no 3198 0.0186740845853956 4691 3163164
SGTC_2845 9003024 42.97 µM -2.08933110137929 0.0464313254803298 no 3199 0.0183389642887962 4679 2990173
SGTC_2953 9074162 66.49 µM -2.09760724293638 0.0457834991014899 no 3200 0.0179699273750205 4688 16451992
SGTC_2105 5350118 200 µM -2.10103882140725 0.0455170269906277 no 3201 0.0178187792718661 4690 2133313
SGTC_403 arphamenine a 50 µM -2.10120374167006 0.0455042519241537 no 3202 0.0178115425505119 4708 5487158 An arginine aminopeptidase inhibitor.
SGTC_2460 5552655 174.22 µM -2.10846874159775 0.0449443450559295 no 3203 0.0174952319086203 4674 5401989
SGTC_2818 7996756 12.99 µM -2.11285428116198 0.0446090486202379 no 3204 0.0173066210067746 4700 2241621
SGTC_863 0466-0191 129 µM -2.12336811730788 0.0438134153560048 no 3205 0.0168615083572057 4736 765160 YPR165W RHO1
SGTC_2316 5844804 197.44 µM -2.13335203261826 0.0430685188872632 no 3206 0.0164479294056531 4692 776813
SGTC_2937 9044753 11.33 µM -2.1354597280788 0.042912579807647 no 3207 0.0163617381849316 4660 6465530 YGL099W LSG1
SGTC_262 fenpropimorph 62.5 µM -2.13550121705879 0.0429095148062854 no 3208 0.0163600454409123 4741 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1523 st012844 44.7 µM -2.14256503727579 0.0423902481348659 no 3209 0.016074020551718 4716 4274103
SGTC_2705 st078069 42.8 µM -2.14715049983594 0.0420558965396942 no 3210 0.0158906510114214 4703 1530061
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.15077209500697 0.0417933372971439 no 3211 0.0157470963357341 4691 5379071
SGTC_266 formosanin C 406 nM -2.15295808473321 0.0416355003960558 no 3212 0.0156609864280979 4593 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3028 9087778 49.47 µM -2.15643512610938 0.0413854397536738 no 3213 0.0155248521683259 4692 17217395
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -2.15834222481326 0.0412488034280117 no 3214 0.0154506170422757 4721 16623 A steroid.
SGTC_2728 chlorpromazine 9.18 µM -2.1627817184507 0.040932146985133 no 3215 0.015278986172325 4772 2726 A thorazine and dopamine antagonist.
SGTC_1684 st024538 14.6195 µM -2.16675059685527 0.0406507302453689 no 3216 0.0151269381444894 4723 6732859
SGTC_2630 antimycin a 100 µM -2.16756825586272 0.04059294895509 no 3217 0.0150957755971323 4643 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2265 7929201 200 µM -2.17028371179263 0.0404015347265777 no 3218 0.0149926798859572 4698 1265108
SGTC_1549 4'-methoxyflavonol 74.6 µM -2.17177844949362 0.0402964828616641 no 3219 0.0149361889694458 4737 97141
SGTC_866 0495-0101 262 µM -2.17321187445863 0.0401959486147479 no 3220 0.0148821872379445 4716 635694
SGTC_245 methotrexate 289.6 µM -2.18864736716634 0.0391262280410712 no 3221 0.0143112401100391 4686 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1686 st019653 115.5 µM -2.19311267695057 0.0388211287091137 no 3222 0.0141496309448588 4737 97252
SGTC_2756 carbadox 75.1 µM -2.19784151258908 0.0385001391485035 no 3223 0.0139802010104062 4649 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1674 st016616 23.6 µM -2.19960754902171 0.0383808181689546 no 3224 0.0139173755636275 4713 625830
SGTC_2382 9035899 200 µM -2.20417780586775 0.0380734311243352 no 3225 0.0137559209909362 4718 6462679
SGTC_126 0417-1624 672.48 µM -2.20504797031281 0.0380151336485805 no 3226 0.0137253642655024 4746 41912 YDL195W SEC31
SGTC_2751 anetholtrithion 17.25 µM -2.22051934968667 0.0369907172327915 no 3227 0.0131917668410719 4691 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2208 7283366 200 µM -2.23902911135737 0.0357948843471629 no 3228 0.0125770110286861 4721 898663
SGTC_2684 capsaicin 100 µM -2.24633407301359 0.0353317455410261 no 3229 0.0123413088296789 4759 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_991 3996-0057 64.7 µM -2.24961684725638 0.0351252222712885 no 3230 0.0122366390329547 4729 715343
SGTC_3249 9135183 49.47 µM -2.254154385204 0.034841392084344 no 3231 0.0120932286420404 4706 4902779
SGTC_950 1165-0508 94.1 µM -2.26032609670777 0.0344583666613849 no 3232 0.0119005097357737 4715 6148369
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.26182312779914 0.0343659819559495 no 3233 0.0118541666640695 4746 4174840
SGTC_2544 sphondin 68.51 µM -2.26969701388401 0.0338834140829504 no 3234 0.0116129863608549 4699 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3022 9087993 49.47 µM -2.27347214896656 0.0336540315174575 no 3235 0.0114988713135547 4775 17173644
SGTC_2627 acetyl isogambogic acid 100 µM -2.27582214997785 0.0335118885773852 no 3236 0.0114283282299991 4717 6857789 A caspase activator and apoptosis inducer.
SGTC_3293 9120939 62.045 µM -2.27973895336685 0.0332760740636744 no 3237 0.0113115877721907 4719 934087
SGTC_2675 theaflavin digallate 100 µM -2.29383438962499 0.0324387288838319 no 3238 0.0109000066277169 4688 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2543 pimpinellin 60.67 µM -2.30279373998306 0.0319155878410584 no 3239 0.0106452254583357 4651 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_534 k292-0788 63.4 µM -2.31126887004796 0.0314271531951668 no 3240 0.0104090041859192 4756 4146317
SGTC_2760 etidronate 98.04 µM -2.31171601898025 0.031401555902712 no 3241 0.010396669015529 4702 3305 A chelator and antioxidant.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.31865517124562 0.0310065248710702 no 3242 0.0102068705239587 4731 6708561
SGTC_1827 berberine 7.24 µM -2.32262042502365 0.0307826437966851 no 3243 0.0100997762425346 4676 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3275 9138069 49.47 µM -2.32443598884029 0.0306805833236925 no 3244 0.0100510692916775 4748 17617007
SGTC_280 3448-3607 3.04 µM -2.32579665634938 0.0306042783071403 no 3245 0.0100147005549772 4733 626179
SGTC_2273 7815444 169.05 µM -2.35179140839373 0.0291764440855659 no 3246 0.00934162438625295 4698 2824616
SGTC_2694 st077685 81.9 µM -2.35813505081784 0.0288365302449342 no 3247 0.00918350480662022 4673 2838096
SGTC_1958 st076513 41.9 µM -2.36686244240718 0.0283742730104417 no 3248 0.00896979957146584 4713 732122 YGL099W LSG1
SGTC_850 0388-0143 75.9 µM -2.37547966083439 0.027923917835276 no 3249 0.00876307913872658 4761 67273
SGTC_1999 st074831 12.5 µM -2.38367020996855 0.0275013960198805 no 3250 0.00857047783153927 4731 17112523
SGTC_151 3013-0144 2.285 µM -2.38759994087433 0.027300574947867 no 3251 0.00847939554373142 4542 906558 YHR107C CDC12
SGTC_1391 3442-0225 151 µM -2.40451430026447 0.0264501110987754 no 3252 0.00809698630994675 4760 5227075
SGTC_3108 9121785 49.47 µM -2.40875085591255 0.0262405965498073 no 3253 0.00800361064745537 4672 17140271
SGTC_113 0099-0221 2.5 µM -2.40917627257645 0.0262196348721786 no 3254 0.00799428677678562 4725 89219
SGTC_1431 4049-0260 9.09 µM -2.41794972096482 0.0257904502115402 no 3255 0.00780411666750123 4780 3854841
SGTC_3053 9095903 49.47 µM -2.42434821001512 0.025481166011472 no 3256 0.00766794644220844 4792 17174018
SGTC_471 1-acyl-paf 4 µM -2.42921284265842 0.0252481077327045 no 3257 0.00756582314209514 4748 16759367
SGTC_2136 5328288 199.296 µM -2.44018224080151 0.0247291268096922 no 3258 0.00733992712307375 4728 262395
SGTC_2595 hexamethylquercetagetin 100 µM -2.44377304249833 0.0245611962017833 no 3259 0.00726728336253087 4716 386331
SGTC_2747 doxorubicin 7.63 µM -2.45123660626015 0.0242152091580585 no 3260 0.00711831686798421 4793 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_536 3852-0578 10.6 µM -2.46223355488776 0.0237128910823461 no 3261 0.0069037360743576 4757 2869208
SGTC_597 k018-0003 82.8 µM -2.47453148684261 0.0231615536283673 no 3262 0.0066705530123846 4784 6786234
SGTC_1363 1636-0063 10.4 µM -2.49276780348885 0.0223638821444091 no 3263 0.00633758527232965 4759 6072185
SGTC_1389 3405-0187 19 µM -2.49455758045474 0.0222868597294658 no 3264 0.00630571315241946 4747 799890
SGTC_1317 1273-0028 910 nM -2.53039863720438 0.0207909407655267 no 3265 0.00569664997085534 4759 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_637 1181-0519 7.26 µM -2.53795473372385 0.0204866612412455 no 3266 0.00557512027645042 4768 6252091 YGR060W ERG25
SGTC_132 0417-1715 25.805 µM -2.54440687056795 0.0202298322377204 no 3267 0.00547317484876468 4743 6769098
SGTC_496 calpeptin 138 µM -2.56296655013687 0.0195062309924552 no 3268 0.00518910233282074 4754 73364 A calpain inhibitor.
SGTC_2561 acetosyringone 100 µM -2.56310644261694 0.0195008614804245 no 3269 0.00518701192838231 4755 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1406 3909-7906 11.9 µM -2.56383375515905 0.0194729651718005 no 3270 0.00517615581455777 4775 X1406
SGTC_878 0828-0289 13.7 µM -2.56458669958599 0.0194441214625545 no 3271 0.00516493841644116 4765 745350 YLR208W SEC13
SGTC_3253 9135987 49.47 µM -2.5646488853507 0.0194417408807768 no 3272 0.00516401293817696 4771 4182430
SGTC_3170 9103054 49.47 µM -2.57450925423544 0.0190673876246049 no 3273 0.00501912005610089 4750 16432970
SGTC_255 tunicamycin 200.472 nM -2.58246684595372 0.0187697599703117 no 3274 0.00490483935146378 4730 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2083 5306046 65.942 µM -2.60991230585871 0.0177733993523521 no 3275 0.00452827178390596 4778 539837
SGTC_719 2810-4230 27.3 µM -2.61197829036639 0.0177002583972145 no 3276 0.00450099851729463 4774 721079
SGTC_3213 9129884 49.47 µM -2.61605440292901 0.0175567069711933 no 3277 0.00444761917703673 4743 17190742
SGTC_776 4476-4378 112 µM -2.62368972945404 0.0172904814400839 no 3278 0.00434914918304444 4772 2892008
SGTC_3340 9146634 11.102 µM -2.63191771348055 0.0170074592679967 no 3279 0.00424522119519712 4763 4907387
SGTC_147 4466-0538 29.23 µM -2.6610564316646 0.0160367872287999 no 3280 0.00389479502954932 4754 6742687 YHR072W ERG7
SGTC_1718 roemerine 11.9335 µM -2.69302619061641 0.0150268149496961 no 3281 0.00354033532928622 4518 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2502 avocadyne acetate 18.59 µM -2.69937213627606 0.0148329757404725 no 3282 0.00347352227857473 4763 3952079
SGTC_1470 k295-0292 231 µM -2.70474133223378 0.0146706547877843 no 3283 0.00341787978480895 4799 5045612
SGTC_3006 9075424 71.4286 µM -2.70990172574157 0.0145160889271626 no 3284 0.0033651573182035 4770 7465181
SGTC_344 k064-0035 6.43 µM -2.71941234014977 0.014234893827204 no 3285 0.00326990133495369 4744 5088750
SGTC_1753 st043925 64 µM -2.72424521156735 0.0140938097753949 no 3286 0.00322243181465294 4787 670181
SGTC_2075 5212009 200 µM -2.72685760198992 0.0140180502626574 no 3287 0.00319703131078347 4762 780898
SGTC_431 k089-0097 107 µM -2.73985430011112 0.0136463406830904 no 3288 0.00307332129468154 4556 5499420
SGTC_933 2914-0560 114 µM -2.76923347888262 0.0128373019148749 no 3289 0.00280941770767998 4771 463887
SGTC_2567 aureobasidin a 60 nM -2.78177444150546 0.0125047911993252 no 3290 0.00270312997737662 4766 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2566 crystal violet carbinol 226 nM -2.79816320654146 0.0120815184725689 no 3291 0.002569706823411 4718 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_416 estradiol valerate 100 µM -2.80475364358695 0.0119148417503251 no 3292 0.00251775254080176 4782 13791 A steroid.
SGTC_2 0422-0095 29 µM -2.8080449994207 0.0118323504675735 no 3293 0.00249216307279328 4721 6790840
SGTC_63 0099-0242 26.702 µM -2.80946695729284 0.0117968654912202 no 3294 0.00248118064020923 4779 3898502 YLR359W ADE13
SGTC_1478 0453-0656 35.7 µM -2.81132444879161 0.0117506508946022 no 3295 0.00246690031608335 4804 5258496
SGTC_3339 9145883 14.936 µM -2.82308440819507 0.0114616923202243 no 3296 0.00237820236310622 4763 2030670
SGTC_2739 tacrine 100.86 µM -2.84463913260905 0.0109480620866737 no 3297 0.00222308816610096 4795 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1081 sertraline 6 µM -2.86755542700824 0.0104240658338965 no 3298 0.00206828170225465 4785 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2168 5727979 200 µM -2.87449555952984 0.0102697494427777 no 3299 0.00202336730210459 4772 695210
SGTC_1909 st060837 51.5 µM -2.88783864872725 0.00997865045445072 no 3300 0.001939493983136 4760 678937
SGTC_2120 5538279 151.968 µM -2.90143619229316 0.00968943611700067 no 3301 0.0018572821005094 4787 2058197
SGTC_714 4296-0578 26.1 µM -2.92166375227559 0.00927275968792798 no 3302 0.00174083598712352 4794 1589775
SGTC_2091 4-phenylthiadiazole 200 µM -2.98238687812117 0.00811463136947935 no 3303 0.00143005161272282 4793 270010
SGTC_840 0245-0196 390 µM -3.01146689752072 0.00760649197828976 no 3304 0.00129994374153086 4804 3827528
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -3.01516040123039 0.00754400070628729 no 3305 0.00128421692544605 4790 688669
SGTC_2913 7966556 36.57 µM -3.01644453050954 0.00752238039199163 no 3306 0.00127879003705002 4759 2976516
SGTC_3343 9148379 18.9835 µM -3.02088607301476 0.00744802037999637 no 3307 0.00126018085646043 4803 1955036
SGTC_1687 st020778 55.3625 µM -3.02719642896253 0.00734348672707689 no 3308 0.00123416751340651 4806 4259299
SGTC_539 4859-0462 2.54 µM -3.02744701388014 0.00733936251419929 no 3309 0.0012331447369544 4783 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1297 1068-0111 14.1 µM -3.03042586333754 0.00729049175490511 no 3310 0.00122104566282546 4793 767057
SGTC_2421 5690543 90.72 µM -3.04711105224999 0.00702202442026274 no 3311 0.00115526165141523 4746 3397993
SGTC_152 4469-0003 551.229 µM -3.0553998149356 0.00689193011339388 no 3312 0.00112380339800493 4790 697280
SGTC_1396 3511-0007 98.6 µM -3.08013048817329 0.00651633718819613 no 3313 0.00103454960941575 4796 X1396
SGTC_2729 fluphenazine 10.66 µM -3.09978129217462 0.00623092106909649 no 3314 0.000968317934365377 4784 3372 An atypical antipsychotic.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -3.10598156162942 0.0061431926897632 no 3315 0.000948242703844703 4786 5282309
SGTC_695 3505-6186 243 µM -3.11770098850729 0.00598035742197545 no 3316 0.000911338101815521 4783 1819379
SGTC_1889 st059080 5.18 µM -3.118710901313 0.00596650594074468 no 3317 0.000908220459789529 4784 176925 Isolated from Daphnopsis sellowiana.
SGTC_783 0848-0141 92.7 µM -3.12262145950902 0.0059131385397135 no 3318 0.000896240637795135 4782 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_259 usnic acid 108.925 µM -3.1258886287795 0.00586887650205166 no 3319 0.00088634335954205 4799 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2606 farnesol 9.78 µM -3.14433878425074 0.00562439539298026 no 3320 0.000832313016989663 4786 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_349 k015-0014 24 µM -3.14520219225045 0.0056131792809392 no 3321 0.000829860393216198 4787 2196908
SGTC_1880 MG-132 525 µM -3.17062804173304 0.0052916662370416 no 3322 0.00076054889440346 4779 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1308 1187-1617 41.4 µM -3.18670250420598 0.00509695388378263 no 3323 0.000719523546017911 4801 2882570
SGTC_1522 st012842 45.6 µM -3.18711038236667 0.00509209727770194 no 3324 0.000718509606055052 4738 3491067 YOR116C RPO31
SGTC_1 0258-0098 57.368 µM -3.2070763014154 0.0048593427527495 no 3325 0.000670457125492811 4730 6790032 YDR047W HEM12
SGTC_3266 9136860 49.47 µM -3.21878253970013 0.00472732976816797 no 3326 0.000643680371231359 4665 4871271 YPR165W RHO1
SGTC_2834 9001755 58.44 µM -3.27500372169393 0.00413685441041707 no 3327 0.000528302908139329 4717 2989575
SGTC_2722 naftopidil 47.16 µM -3.27645914564488 0.004122486265371 no 3328 0.000525587596787413 4787 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2155 5570423 76 µM -3.32911741261462 0.00363176031238967 no 3329 0.0004356083418886 4790 797402
SGTC_1476 4112-3294 3.34 µM -3.39527915124529 0.00308981103340559 no 3330 0.000342793299885865 4797 704369
SGTC_2980 9014342 25.29 µM -3.51092503654489 0.00231470424829483 no 3331 0.000223275152214686 4789 2996599
SGTC_444 curcumin 90.4 µM -3.60340877806118 0.00182662839688567 no 3332 0.000157035502378554 4772 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1786 berberine 21.6 µM -3.64384338171726 0.0016442836044035 no 3333 0.000134298449481229 4766 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_707 0865-0008 204 µM -3.68444549411155 0.0014780170025426 no 3334 0.000114600532074266 4807 723043
SGTC_297 0986-0032 24 µM -3.82132270276037 0.00102420618571865 no 3335 6.6368912761984e-05 4805 2847425
SGTC_1951 sophoraflavanone G 9.2 µM -3.83401432775582 0.000989385923226764 yes 3336 6.30343967049544e-05 4785 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3212 9128307 49.47 µM -3.8349714321057 0.000986804621158072 yes 3337 6.27894448037283e-05 4775 27243542
SGTC_2166 5933061 31.504 µM -3.88655030893204 0.00085650436385667 yes 3338 5.08394308695748e-05 4786 2877375
SGTC_1259 0671-0132 43 µM -4.33431689959248 0.000233884678120406 yes 3339 7.31067123523802e-06 4806 X1259
SGTC_712 r015-0009 80.6 µM -4.37032644650819 0.000209572273039764 yes 3340 6.20304628788799e-06 4810 6813872 YLR060W FRS1
SGTC_1930 st074634 34.3 µM -4.53509591744764 0.000125536182616794 yes 3341 2.87886564926905e-06 4797 684253 YOR116C RPO31
SGTC_2095 5432005 200 µM -4.66049419933567 8.40389904464876e-05 yes 3342 1.57725525717707e-06 4809 783734
SGTC_438 sphingosine 6.67 µM -4.75423985029924 6.18600915475082e-05 yes 3343 9.95972241954922e-07 4803 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_343 4130-2827 29.8 µM -4.7808115459635 5.6657837513037e-05 yes 3344 8.72944840242872e-07 4809 1118244
SGTC_810 3825-7150 143 µM -4.86548585398084 4.26984638753219e-05 yes 3345 5.70879888560491e-07 4807 22330411 YGL099W LSG1
SGTC_1775 st081588 35.1725 µM -4.88906222414973 3.94331172179097e-05 yes 3346 5.06587346051763e-07 4807 1426443 YGL099W LSG1
SGTC_2887 9044784 58.44 µM -5.07906119790208 2.05073403218807e-05 yes 3347 1.89652261715155e-07 4808 6465546
SGTC_58 0957-0393 9 µM -5.46488202263446 5.07059069064278e-06 yes 3348 2.31607387583516e-08 4713 6997992
SGTC_2268 7933382 153.85 µM -5.47516106904241 4.87904777747235e-06 yes 3349 2.18556918534724e-08 4805 935025 YOR257W CDC31
SGTC_62 0180-0423 3.232 µM -5.9193044939579 8.67149515983992e-07 yes 3350 1.61652953652974e-09 4808 30102 YGL099W LSG1
SGTC_795 0685-0265 78 µM -6.05040923008314 5.08490002531158e-07 yes 3351 7.22391751495196e-10 4810 302754