SGTCid condition conc unit JJJ3|YJR097W.score JJJ3|YJR097W.strain.pval JJJ3|YJR097W.strain.significant JJJ3|YJR097W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2651 TUB2.036 5 µM 8.74908330624675 1.93315190104495e-17 yes 1 1.07546418440985e-18 32 15992207 YFL037W TUB2 SGTC_221 trifluoperazine 10.304 µM 8.37725014118759 3.84664427426279e-16 yes 2 2.7089310433601e-17 79 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1754 st042065 16.137 µM 7.78089456611148 3.57823452513753e-14 yes 3 3.60067472439113e-15 60 1126236 YIL048W NEO1 SGTC_2679 rapamycin 1 nM 7.66666009192484 8.21644895003213e-14 yes 4 8.8266393988592e-15 45 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2246 7293507 91.5585 µM 7.06722180091485 5.30288331429171e-12 yes 5 7.90331016092301e-13 9 887656 SGTC_796 1234-0020 70.7 µM 6.81751013653481 2.73264049441708e-11 yes 6 4.63159352024979e-12 5 46495034 SGTC_58 0957-0393 9 µM 6.31174691155186 6.3613206623658e-10 yes 7 1.3795158502e-10 193 6997992 SGTC_888 0916-0002 6.97 µM 5.67241131888788 2.4420702504486e-08 yes 8 7.04007061896806e-09 25 2802138 YIL048W NEO1 SGTC_1888 azatryptophan 97.5 µM 5.45139827192944 7.91027243022632e-08 yes 9 2.49876532915154e-08 5 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_989 1501-0895 10.3 µM 5.28093169682232 1.90048663866e-07 yes 10 6.42643015468636e-08 2 2830112 SGTC_1941 st076221 61.8 µM 5.22674146315811 2.49750478314361e-07 yes 11 8.62617347236614e-08 40 2828568 SGTC_445 e6 berbamine 66 µM 5.15080782230573 3.64609989868343e-07 yes 12 1.29683426715471e-07 55 6610268 A calcium/calmodulin antagonist. SGTC_971 1315-0384 26.7 µM 5.10424845070287 4.58643005354919e-07 yes 13 1.66055856851781e-07 7 6769120 SGTC_977 1348-1378 135 µM 5.04355823598755 6.16734845689063e-07 yes 14 2.28476803481726e-07 10 X977 SGTC_2016 5121758 140 µM 5.00760885072625 7.33859284182104e-07 yes 15 2.75551930655098e-07 19 2795203 SGTC_2858 9025781 8.96 µM 5.0070877572691 7.35704981817649e-07 yes 16 2.76298682691673e-07 67 4894980 YPL153C RAD53 SGTC_1801 st050089 28.441 µM 4.87846816966959 1.35751233948774e-06 yes 17 5.3456456527334e-07 78 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1641 st009299 47.1 µM 4.73551559308379 2.63575083300641e-06 yes 18 1.09249452004713e-06 2 4046054 SGTC_178 4092-0806 87.505 µM 4.73101439962927 2.69060060425486e-06 yes 19 1.11700336092392e-06 61 2169044 SGTC_901 1112-0062 60.1 µM 4.62866081074244 4.2769420689361e-06 yes 20 1.84019004595934e-06 5 1908457 SGTC_1511 0906-3109 28.5 µM 4.62800583547646 4.28951677355598e-06 yes 21 1.84601808104767e-06 26 2882180 SGTC_2953 9074162 66.49 µM 4.57796574826571 5.36202026204949e-06 yes 22 2.34759773803717e-06 15 16451992 SGTC_1760 st045453 10.4495 µM 4.53762038661572 6.40865862725193e-06 yes 23 2.84462767482136e-06 122 3323419 YIL048W NEO1 SGTC_1800 st050079 29.0735 µM 4.40616664563141 1.13428611157233e-05 yes 24 5.26080143627295e-06 102 3645560 SGTC_2603 homopterocarpin 100 µM 4.40041780801886 1.16255736123891e-05 yes 25 5.40213231652589e-06 19 101795 A weak amylase inhibitor. SGTC_2297 7971671 152.32 µM 4.3347644565416 1.53679181816202e-05 yes 26 7.29581381767775e-06 18 909016 SGTC_3037 9091026 49.47 µM 4.26197675321481 2.08472039346043e-05 yes 27 1.01313262925164e-05 107 25236398 YIL048W NEO1 SGTC_2823 7987624 58.44 µM 4.24322849606907 2.25335331450429e-05 yes 28 1.10163447304601e-05 22 2239440 SGTC_3011 9081274 71.4286 µM 4.10669599309829 3.93342232261728e-05 yes 29 2.00679457170017e-05 13 6625322 SGTC_579 4491-1009 110 µM 4.07747503927572 4.42204027027193e-05 yes 30 2.27637078170766e-05 20 1271041 SGTC_3218 9131285 49.47 µM 3.98837917878828 6.29006169753291e-05 yes 31 3.3263135141408e-05 42 17156417 SGTC_871 0574-0004 149 µM 3.84237641283404 0.000110375272497688 yes 32 6.09243866560155e-05 51 9551173 SGTC_943 3253-1379 105 µM 3.76586938318945 0.000147094991222504 yes 33 8.29852735929234e-05 29 668464 SGTC_3114 9122766 49.47 µM 3.71781007207647 0.000175714479116261 yes 34 0.000100478629090039 21 17176985 SGTC_449 xestospongin c 11.1929 µM 3.71119991109747 0.000180035600797848 yes 35 0.000103139555631237 81 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2498 4'-Methoxychalcone 54.63 µM 3.56705832371052 0.000302904452042771 yes 36 0.000180505575977243 46 641818 YHR062C RPP1 SGTC_1119 parthenolide 318.541 nM 3.53329382864704 0.000341266851764478 yes 37 0.000205208029530129 57 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1504 k297-0033 30 µM 3.53119785730517 0.000343791163319207 yes 38 0.000206841089590589 22 4388117 SGTC_3252 9135871 49.47 µM 3.53019160952847 0.000345009207686701 yes 39 0.000207629404939248 19 17682838 SGTC_1638 st008370 60.6 µM 3.50505419859082 0.000376770681358109 yes 40 0.000228257168967638 44 24207134 SGTC_1574 spiramycin 23.7 µM 3.49664012980142 0.000387994586776281 yes 41 0.000235578481912981 43 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3166 9102297 49.47 µM 3.45252087769869 0.000452100386590879 yes 42 0.000277687248197399 44 25237072 SGTC_2479 5617353 43.85 µM 3.43419256849176 0.00048151171604994 yes 43 0.000297160907624619 62 2731746 SGTC_1402 3909-7673 35.9 µM 3.42733054401191 0.000492971894916084 yes 44 0.000304773303541588 29 5328014 SGTC_138 0850-0259 40.9225 µM 3.42465362882065 0.000497510658606466 yes 45 0.000307791846186985 233 6813004 SGTC_2594 a-mangostin 100 µM 3.41704922541474 0.000510615989185022 yes 46 0.000316519161200219 50 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_485 niflumic acid 177 µM 3.34290817662765 0.000656215068081106 yes 47 0.000414526640734016 22 4488 A COX2 inhibitor. SGTC_2962 9082311 13.18 µM 3.28253228456581 0.000802122496236288 yes 48 0.000514396021862448 48 16459453 SGTC_2110 5483698 200 µM 3.27134276458263 0.000832242662726883 yes 49 0.000535190456868937 42 2848765 YHR062C RPP1 SGTC_1334 1486-0610 236 µM 3.26354916084389 0.000853832713594388 yes 50 0.000550130469702406 42 3742339 SGTC_1093 fluphenazine 7.97 µM 3.25226211275367 0.000886014653499374 yes 51 0.000572451941820211 36 6602611 An atypical antipsychotic. SGTC_2683 piperine 63.03 µM 3.25077282874244 0.000890343227723988 yes 52 0.00057545890354195 34 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_917 harmaline 728.087 nM 3.22479996035229 0.00096902716292229 yes 53 0.000630303593847377 56 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_685 1278-0033 54.9 µM 3.19879071943451 0.00105417402718889 no 54 0.000690026554172303 62 3590572 SGTC_1476 4112-3294 3.34 µM 3.18268266365094 0.00111029304356999 no 55 0.000729587214043407 44 704369 SGTC_1803 st050068 52.4 µM 3.17270851989609 0.00114640110502361 no 56 0.000755120321451696 245 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1900 st060200 72.8 µM 3.15863864979838 0.00119916684599379 no 57 0.000792539455240236 50 688945 SGTC_3234 9132280 49.47 µM 3.15361080951361 0.00121855544190119 no 58 0.000806319962207413 52 17612295 SGTC_2250 alverine citrate 130 µM 3.14073424818517 0.00126952604425828 no 59 0.00084262438259064 242 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_678 1218-2179 85.9 µM 3.12831862994415 0.00132051131197726 no 60 0.000879047389928643 13 6820081 YOR116C RPO31 SGTC_714 4296-0578 26.1 µM 3.11663108001689 0.0013702100627753 no 61 0.000914651678716887 11 1589775 SGTC_3251 9135047 49.47 µM 3.05188416086844 0.00167783409376921 no 62 0.00113704921659621 26 17682963 SGTC_1304 1165-0502 251 µM 3.04527846150983 0.00171251819560512 no 63 0.00116232484519953 108 767425 SGTC_3231 9132313 49.47 µM 3.02726001051389 0.00181047027174029 no 64 0.00123390792826286 35 4905967 SGTC_1933 st074711 15.9 µM 3.00975368967389 0.00191049145007342 no 65 0.00130729813664297 94 17250958 SGTC_1358 1509-0022 2.48 µM 2.99558917391518 0.00199506573284832 no 66 0.00136957598754487 50 3258434 SGTC_1362 1611-0397 101 µM 2.98639560785329 0.00205176368944771 no 67 0.00141143599463816 59 27816 SGTC_1514 1189-1591 158 µM 2.98126912112907 0.00208401069754001 no 68 0.00143528203511704 101 767698 YMR146C TIF34 SGTC_955 1216-0110 33 µM 2.96623250123657 0.0021812649202126 no 69 0.00150736244081811 125 3619719 SGTC_3127 9126946 49.47 µM 2.93186203667113 0.00241919303950562 no 70 0.00168468195311137 55 27243249 SGTC_2896 9052656 71.43 µM 2.91139073556707 0.00257182667420163 no 71 0.00179911866276557 220 6469436 SGTC_1188 1403-0014 4.57 µM 2.87936748868261 0.00282810135324693 no 72 0.00199236856597179 124 9614867 SGTC_707 0865-0008 204 µM 2.84113250864052 0.00316411578663467 no 73 0.0022476814703767 51 723043 SGTC_2108 5365811 200 µM 2.83905267889954 0.00318338411357691 no 74 0.00226238431642581 68 780283 SGTC_578 3460-0051 92 µM 2.82654625830855 0.00330149110887198 no 75 0.00235264737418788 62 2876744 SGTC_147 4466-0538 29.23 µM 2.82348687666642 0.00333097636632977 no 76 0.00237521853413266 98 6742687 YHR072W ERG7 SGTC_476 mead acid 10 µM 2.79393680543203 0.00362819119677417 no 77 0.00260353265745926 28 5312531 An omega 9 fatty acid. SGTC_1096 rimcazole 32.2 µM 2.7929990847476 0.00363800067860089 no 78 0.00261109198519812 55 18528119 A dopamine reuptake inhibitor. SGTC_664 1222-0054 14.9 µM 2.78672520329087 0.00370424619184422 no 79 0.00266218039690643 97 6813991 SGTC_146 3448-8650 53.125 µM 2.77072659801381 0.00387809824452976 no 80 0.00279656839955518 244 2891488 YIL048W NEO1 SGTC_1886 st057356 49.9 µM 2.76501317731087 0.00394193411527894 no 81 0.00284602481891613 74 24207747 SGTC_601 0986-0029 62.9 µM 2.75530356967311 0.00405258082040836 no 82 0.00293188511353374 115 24747981 SGTC_3337 9144342 33.5465 µM 2.74106306596691 0.0042198905785021 no 83 0.00306203758425399 86 17682949 SGTC_2111 5486399 200 µM 2.73568458048927 0.0042846716331513 no 84 0.00311253316415865 129 689674 SGTC_573 3702-0553 84.7 µM 2.73442420726245 0.00429998016459378 no 85 0.00312447399624903 63 1222756 SGTC_1487 3970-0795 2.82 µM 2.72297968905627 0.00444123897027961 no 86 0.0032348017613018 74 3765103 SGTC_715 0868-0130 184 µM 2.71660051385899 0.00452176304561781 no 87 0.00329780822404552 58 2876258 SGTC_2402 5553605 200 µM 2.70911765935771 0.0046178783207301 no 88 0.00337312054211829 105 6758546 SGTC_293 4049-0273 38.5 µM 2.70104553632633 0.00472360308857565 no 89 0.00345609370332518 60 1380311 SGTC_1481 3346-2004 36 µM 2.69537455986496 0.00479916458935214 no 90 0.00351547728277383 61 2770522 SGTC_355 1311-2252 105 µM 2.69069622423694 0.00486230916906439 no 91 0.00356515443173414 96 5338538 SGTC_317 4495-0002 170 µM 2.68372132269847 0.0049578263093289 no 92 0.00364038834257517 54 15991618 SGTC_432 NS 1619 61.3 µM 2.66118711967306 0.00527794459511824 no 93 0.00389328354881896 106 4552 A K+/calcium channel activator. SGTC_712 r015-0009 80.6 µM 2.65947021900096 0.00530307229169505 no 94 0.00391318243796427 80 6813872 YLR060W FRS1 SGTC_1293 1000-1278 195 µM 2.65499198355486 0.00536911487474231 no 95 0.00396551466320354 88 678847 SGTC_291 SEC14.278 35.5 µM 2.64816121970101 0.0054712599861993 no 96 0.00404654598256896 64 1068044 SGTC_932 2857-0803 154 µM 2.64786163784209 0.00547577910816773 no 97 0.0040501335232642 95 674898 SGTC_1745 st081495 74 µM 2.60617886560426 0.00613782704291553 no 98 0.00457793176282363 200 13842402 YBL026W LSM2 SGTC_1424 4048-1941 275 µM 2.60391771797524 0.00617568810110387 no 99 0.00460824402012207 104 X1424 SGTC_2780 5215298 71.43 µM 2.59534333457574 0.00632114542189667 no 100 0.00472482358867023 141 2834131 SGTC_793 0488-0545 106 µM 2.58583157787456 0.006486045432734 no 101 0.00485721928949168 100 292548 SGTC_1510 1123-0200 71.5 µM 2.57461456437581 0.00668538925778406 no 102 0.00501759232045163 156 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1818 st052136 56.3 µM 2.57354101564526 0.00670474890965007 no 103 0.00503318573238077 151 674169 SGTC_1288 0973-0013 65.5 µM 2.56053874185742 0.00694318702761302 no 104 0.00522550051051403 96 4315430 SGTC_2302 7771753 200 µM 2.55558424222092 0.00703599486412989 no 105 0.00530048485101604 164 2203047 SGTC_2161 5662504 8.5105 µM 2.5549966364552 0.0070470742157237 no 106 0.00530944120469094 99 2859334 SGTC_2264 7948757 110.76 µM 2.53817236196421 0.00737089743648462 no 107 0.00557165439676219 108 2971411 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.5221325717423 0.00769176089040582 no 108 0.00583228691007949 183 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1904 st060225 78 µM 2.52205480886476 0.00769334596211328 no 109 0.00583357640078916 93 66595 SGTC_2002 4023503 131 µM 2.51886225479651 0.00775866976767542 no 110 0.00588673525385329 145 4736863 YCR052W RSC6 SGTC_347 4534-1311 26.2 µM 2.5131570200005 0.00787662253791595 no 111 0.00598280321463532 95 2862016 SGTC_2716 st080858 38.6235 µM 2.50371162520077 0.0080753704641948 no 112 0.00614490790171502 90 5296050 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.48502670087325 0.00848155612969961 no 113 0.00647708589770315 100 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2720 fluspirilene 36.88 µM 2.47635306474272 0.00867612742137231 no 114 0.0066366123652073 71 3396 An atypical antipsychotic. SGTC_721 1187-1332 279 µM 2.46296937828659 0.00898403798514659 no 115 0.00688958417660158 81 25730 SGTC_75 0159-0059 199.013 µM 2.46190989423712 0.00900881686642402 no 116 0.0069099690789385 120 5377270 SGTC_1829 berberine 14.4 µM 2.46005220324934 0.00905240848173993 no 117 0.00694584039296309 106 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_889 0919-1524 82.7 µM 2.45531580706138 0.00916438718761718 no 118 0.00703804339324263 103 3905452 SGTC_1608 st001473 40.5 µM 2.45349697120751 0.00920770957825673 no 119 0.00707373654106048 142 7292267 SGTC_2104 5389443 200 µM 2.45322443340326 0.00921421650535764 no 120 0.00707909860760552 126 2244536 SGTC_1714 st033236 13.627 µM 2.45098549965961 0.00926782427739306 no 121 0.00712328461457627 133 2916566 SGTC_2433 5607874 27.82 µM 2.43802968011638 0.00958342204740166 no 122 0.00738378072721322 127 2252428 SGTC_3152 9099253 49.47 µM 2.42031342173993 0.0100301676472654 no 123 0.00775356744263008 284 25236131 SGTC_1121 fusaric acid 630.51 nM 2.40902585912104 0.0103241894916204 no 124 0.00799758230139904 141 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_64 000l-0018 272.079 µM 2.40576769770283 0.0104104447293081 no 125 0.00806926162245284 303 6811119 SGTC_154 3389-1638 511.116 µM 2.39226916827088 0.0107745255412157 no 126 0.00837227861210747 130 5238686 SGTC_2549 cedrol 20.94 µM 2.38528204736944 0.0109672989075617 no 127 0.00853301576657632 110 6708665 A sedative which affects the nervous system. SGTC_448 monastrol 171 µM 2.38518521547089 0.0109699914282398 no 128 0.00853526225478507 103 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_570 0987-0065 62.6 µM 2.38318717070137 0.0110256778356214 no 129 0.00858173261573624 76 3104428 SGTC_3266 9136860 49.47 µM 2.38269721299845 0.0110393706612681 no 130 0.00859316184261133 168 4871271 YPR165W RHO1 SGTC_2707 st078556 66.6 µM 2.37404678256605 0.0112835712875641 no 131 0.00879716055162942 93 17250899 SGTC_2808 7946468 45.46 µM 2.37104306265439 0.0113694573235465 no 132 0.00886898215203686 160 2970879 SGTC_2179 6298986 200 µM 2.37052227579418 0.0113844059378345 no 133 0.00888148675917221 112 738374 SGTC_1401 3807-4679 7.6 µM 2.36725872236935 0.0114784720347968 no 134 0.00896020022966972 108 3291456 SGTC_414 piperonyl butoxide 100 µM 2.36396578772765 0.0115740685299849 no 135 0.00904024109391128 103 5794 A potent inhibitor of cytochrome P450. SGTC_1515 3460-0031 42.1 µM 2.36130659296408 0.0116517708849819 no 136 0.00910533406473709 101 2876596 SGTC_1668 st014914 51.6 µM 2.34419428718106 0.0121627134419433 no 137 0.00953411776943283 93 2839556 SGTC_1463 k081-0032 34.1 µM 2.3408949729115 0.0122634273425265 no 138 0.00961878898965349 79 977755 SGTC_1679 SEC14.276 6.7 µM 2.32780867719688 0.0126700455263526 no 139 0.00996113256011111 202 1005053 YMR079W SEC14 SGTC_2117 5521686 200 µM 2.32625306051931 0.0127191491110818 no 140 0.0100025272621629 145 803312 SGTC_2654 protoveratrine a 100 µM 2.32383368628007 0.0127958446909728 no 141 0.010067204763585 105 5702278 A heart drug and vasodilator. SGTC_2778 tioconazole 65.09 nM 2.31795840133503 0.0129837620384011 no 142 0.0102257909791097 213 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3153 9100258 49.47 µM 2.30376615359607 0.0134475625787288 no 143 0.0106178870224064 161 25236848 SGTC_1348 1493-0373 93.8 µM 2.30223878996456 0.0134983189467436 no 144 0.0106608547839981 135 3010129 SGTC_422 cantharidin 155 µM 2.29550564470279 0.0137240467613649 no 145 0.0108520816470219 221 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_686 1319-0111 510 µM 2.28857307143379 0.0139598555354087 no 146 0.0110520849979932 158 4562600 SGTC_55 0767-0285 6.563 µM 2.27292229507687 0.0145050869934038 no 147 0.0115154314982506 189 3116166 SGTC_903 1134-0042 114 µM 2.27033409522135 0.0145969970240167 no 148 0.011593659931348 158 701009 SGTC_2333 9017922 200 µM 2.2580436244148 0.0150403171607954 no 149 0.0119714699043777 172 3163164 SGTC_2017 5132927 60.65 µM 2.23963031169577 0.0157261249993268 no 150 0.0125574665862912 180 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1950 st077106 7.18 µM 2.23262910328193 0.0159938369950474 no 151 0.0127867066221571 175 13831864 SGTC_1920 st075728 45.7 µM 2.22572034825102 0.0162618337776969 no 152 0.0130164594600016 168 3400306 SGTC_1299 1079-1439 3.74 µM 2.22409652503318 0.016325378702562 no 153 0.0130709753262899 136 323161 SGTC_696 1560-0013 611 µM 2.2204265260848 0.0164697802933891 no 154 0.0131949140385656 163 1650269 SGTC_2581 avocatin a 64 µM 2.21090146870294 0.0168496690783296 no 155 0.0135213304800663 207 6710728 A skin care supplement. SGTC_1596 piperlongumine 63 µM 2.19970590631882 0.0173057398428877 no 156 0.0139138837427348 160 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1444 4112-3581 28 µM 2.19777543083752 0.0173854376339647 no 157 0.0139825565576219 152 2877249 SGTC_1426 4048-4480 71.7 µM 2.18928548388281 0.0177396675633029 no 158 0.014288048380427 152 14224343 SGTC_1180 1193-0155 285 µM 2.1741721020267 0.0183854957973489 no 159 0.014846106343464 171 2921347 SGTC_681 1642-0006 26.6 µM 2.17219233323666 0.018471561312918 no 160 0.0149205793657924 103 4446530 SGTC_872 0588-0139 234 µM 2.17185984689343 0.0184860489253753 no 161 0.0149331179622314 202 2047100 SGTC_2663 amphotericin b 100 µM 2.16083576373054 0.0189719163511686 no 162 0.0153540141833527 142 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3044 9093193 49.47 µM 2.15962432013658 0.0190259650895417 no 163 0.0154008820715489 213 25236277 SGTC_2644 guaiazulene 100 µM 2.15445792970865 0.0192579366986296 no 164 0.0156021389046902 130 3515 A coloring agent. SGTC_2470 5664817 21.68 µM 2.13742746891074 0.0200397004237092 no 165 0.0162816196043141 139 2859561 SGTC_1827 berberine 7.24 µM 2.12854348259737 0.0204580849352372 no 166 0.016646024377617 180 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_22 0964-0034 14.468 µM 2.1282651891116 0.0204713096263208 no 167 0.0166575512983251 237 138402 SGTC_633 0437-0093 97.7 µM 2.12744984616712 0.0205100969722764 no 168 0.0166913621420848 155 2831118 SGTC_1062 mesoridazine 14.2 µM 2.12010212423817 0.0208624588211126 no 169 0.0169987169322079 197 4078 A neuroleptic. SGTC_1887 st057648 70.8 µM 2.11922696593147 0.0209047668032198 no 170 0.017035645205752 176 688672 SGTC_640 3381-0960 37.1 µM 2.11797861903706 0.0209652415937005 no 171 0.0170884392437547 167 1745025 SGTC_130 0136-0219 337.655 µM 2.10681151836064 0.0215128353460777 no 172 0.0175669603351553 194 234244 SGTC_191 3914-0123 66.505 µM 2.0988386755407 0.0219111496517428 no 173 0.0179155621133307 81 3144412 SGTC_85 0868-0259 160.055 µM 2.09675942560862 0.0220160445826728 no 174 0.0180074385090741 141 83173 SGTC_1733 st037357 54.9 µM 2.09669603661959 0.0220192491062724 no 175 0.0180102457947079 227 1272339 YGL099W LSG1 SGTC_301 4119-0100 24.5 µM 2.08851124163016 0.0224363384526884 no 176 0.0183758712069972 265 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2841 9004761 38.96 µM 2.08605746732178 0.0225626712287414 no 177 0.0184867089074097 196 2991039 SGTC_482 fipronil 114 µM 2.08430386632617 0.0226533225323828 no 178 0.018566267944711 107 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1423 4048-0112 5.59 µM 2.06223159377302 0.0238208275665317 no 179 0.0195928460723388 205 X1423 SGTC_885 0865-0106 16.8 µM 2.05361074334272 0.0242903622549137 no 180 0.0200066907517987 226 2793380 SGTC_2013 4024628 200 µM 2.05263184683128 0.024344165902444 no 181 0.0200541482244549 232 5230760 SGTC_3294 9122953 26.2835 µM 2.03813334453941 0.0251528421692088 no 182 0.0207682996365435 202 16459826 SGTC_2937 9044753 11.33 µM 2.03383789386712 0.0253967072080537 no 183 0.0209839712456154 259 6465530 YGL099W LSG1 SGTC_1662 st014054 52 µM 2.03004078014932 0.0256139263933687 no 184 0.0211761971221677 151 2838777 SGTC_2699 st077704 54.6 µM 2.01825308320388 0.0262981902631063 no 185 0.0217824551186104 246 645852 SGTC_397 arbidol 50 µM 2.0172434649283 0.0263575014612411 no 186 0.0218350561191862 223 131410 A RNA synthesis inhibitor. SGTC_1391 3442-0225 151 µM 2.00751975759657 0.0269344764221467 no 187 0.0223471745169918 176 5227075 SGTC_290 2043-6722 48.1 µM 1.99393420904153 0.0277582241687698 no 188 0.0230796224296173 204 773758 YLR208W SEC13 SGTC_2837 9008476 45.46 µM 1.98966996026413 0.0280210719204323 no 189 0.0233136519471189 252 2992805 SGTC_1072 oxiconazole 14.9 nM 1.98947559474389 0.0280331018104677 no 190 0.0233243664910478 266 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1126 isoteolin 1.0172 µM 1.9832993180869 0.0284176164492154 no 191 0.0236670027693874 239 133323 SGTC_2931 9014674 55.67 µM 1.98170342621747 0.028517681806909 no 192 0.0237562217636602 238 2996810 SGTC_375 3970-0961 9.27 µM 1.98170153259671 0.0285178007142987 no 193 0.0237563277950449 231 2898222 SGTC_2537 larixol 68.93 µM 1.97795149232851 0.0287540900051798 no 194 0.0239670895822187 254 6708759 SGTC_2055 5235184 200 µM 1.97768943410507 0.0287706629165066 no 195 0.023981876476822 242 2836034 SGTC_304 1310-0298 97 µM 1.95782369552418 0.0300503171233911 no 196 0.0251253519803605 297 1550234 SGTC_1877 wortmannin 25 µM 1.95751329585261 0.0300706800547923 no 197 0.0251435750661247 334 312145 A covalent inhibitor of PI 3-kinase. SGTC_1433 4060-0023 7.6 µM 1.95052587568757 0.0305321068000798 no 198 0.025556736179178 217 3840627 SGTC_659 k018-0002 107 µM 1.94906632086264 0.030629227893266 no 199 0.0256437525313358 235 6797879 YHR007C ERG11 SGTC_744 1594-0068 283 µM 1.94011068086205 0.0312307664174226 no 200 0.0261831201211891 284 668392 SGTC_2162 5663267 200 µM 1.93781773986078 0.0313863416399087 no 201 0.026322731335577 199 6456493 SGTC_510 ag-490 170 µM 1.92929721636272 0.0319700808605687 no 202 0.0268469875647917 173 5328779 SGTC_1123 mangostin 811.285 nM 1.92523531305017 0.0322515007535889 no 203 0.0270999630643144 284 5281650 An antioxidant. SGTC_2877 9040724 71.43 µM 1.92460487867547 0.0322953617366271 no 204 0.0271394043011563 201 6463895 SGTC_2004 4023728 41.89 µM 1.92350202650895 0.0323722084479761 no 205 0.0272085161189899 273 360084 YDR527W RBA50 SGTC_2815 7968870 71.43 µM 1.92345466121505 0.0323755122367612 no 206 0.0272114876186506 288 2977326 YHR190W ERG9 SGTC_2214 7179297 48.276 µM 1.92232729126504 0.032454229860291 no 207 0.0272822940246945 164 769744 SGTC_2678 equilin 100 µM 1.91930329681481 0.0326661577333483 no 208 0.0274729805205816 242 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_698 k064-0052 127 µM 1.9189903751519 0.0326881529479852 no 209 0.0274927759697179 153 5088751 SGTC_2971 9092186 9.93 µM 1.90756039785456 0.0334999720220736 no 210 0.0282240288724131 239 25236400 SGTC_1683 st010134 710 nM 1.90023682535647 0.0340288034890736 no 211 0.0287010238230363 270 3818134 SGTC_2814 7977482 42.97 µM 1.89682018559522 0.0342778554308659 no 212 0.0289258371301513 343 6456762 SGTC_2010 4012422 159 µM 1.89157118936971 0.0346633920714386 no 213 0.0292740687834489 257 952393 SGTC_2864 9034755 47.6 µM 1.889688583941 0.0348025334551186 no 214 0.0293998109012554 250 4930451 SGTC_3128 9127691 49.47 µM 1.88860692931118 0.0348826846198015 no 215 0.0294722589098084 219 41316314 SGTC_988 1497-1057 103 µM 1.8873003358221 0.0349797058823612 no 216 0.0295599706562347 263 3533044 SGTC_2376 9072922 81.32 µM 1.88625582020286 0.0350574257223977 no 217 0.0296302448300319 287 17087968 SGTC_2816 7982706 58.44 µM 1.8687229754868 0.036383286915857 no 218 0.0308306829017515 305 2981853 SGTC_1866 st057638 64 µM 1.86870493070303 0.0363846723417662 no 219 0.0308319388265633 234 688802 SGTC_3352 9151559 45.5865 µM 1.8603083967185 0.0370340336520657 no 220 0.0314209531317487 250 17159339 SGTC_1049 3226-0134 66 µM 1.85495573839342 0.0374529135229576 no 221 0.0318012737172073 306 5702385 SGTC_1134 3477-0009 42.5 µM 1.85476822822962 0.0374676572591407 no 222 0.03181466545632 313 3973534 SGTC_765 1319-0117 244 µM 1.85351868594688 0.037566028596246 no 223 0.0319040251954187 244 3487746 YGL099W LSG1 SGTC_695 3505-6186 243 µM 1.8487350464964 0.0379445756901039 no 224 0.0322480402329613 254 1819379 SGTC_2317 5986382 200 µM 1.84758016096259 0.038036430934826 no 225 0.0323315509398671 240 877883 SGTC_302 1094-0063 18.9 µM 1.84756865590432 0.0380373469155345 no 226 0.0323323837768602 201 5440289 SGTC_3139 9095020 49.47 µM 1.83596637893322 0.0389702678437525 no 227 0.0331813146300602 169 25236292 SGTC_1199 1638-0010 4.46 µM 1.82434338050275 0.039923451911268 no 228 0.0340500879914653 311 3111136 SGTC_134 0269-0018 6.916 µM 1.81512539440489 0.0406928041960831 no 229 0.0347523207366934 383 4378915 SGTC_2588 indole-3-carbinol 100 µM 1.81311984670944 0.0408617749732941 no 230 0.0349066693669748 339 3712 Induces cell cycle arrest. SGTC_3084 9116877 49.47 µM 1.81184879641677 0.0409691574818505 no 231 0.0350047814718745 201 27241325 SGTC_2145 5634607 200 µM 1.79906981256149 0.0420615352051661 no 232 0.0360038190625372 221 308662 SGTC_2809 7964133 12.99 µM 1.7977293392314 0.0421774755878144 no 233 0.0361099548383933 332 1253665 SGTC_2521 angolensin 13.4 µM 1.79571828894963 0.0423519004909595 no 234 0.036269665849741 244 821428 A flavenoid. SGTC_2038 4100038 30.985 µM 1.79015110268653 0.0428378057452139 no 235 0.0367148116907428 315 3596803 SGTC_447 ml7 120 µM 1.78842527937722 0.0429893475532174 no 236 0.0368537104227765 279 4216 Selective myosin light chain kinase inhibitor. SGTC_3125 9127534 49.47 µM 1.78805042892584 0.0430223197664234 no 237 0.0368839360853692 191 1639235 SGTC_497 capsazepine 133 µM 1.7821338228428 0.0435454616139789 no 238 0.0373637056782507 260 2733484 A calcium channel blocker. SGTC_2556 citropten 84.59 µM 1.78180029051778 0.0435751044983884 no 239 0.0373909024415154 335 2775 A potential DNA crosslinker. SGTC_2259 7964009 200 µM 1.78124209960594 0.0436247504814871 no 240 0.0374364544014305 270 313134 SGTC_3270 9137563 49.47 µM 1.78103818023609 0.04364289862644 no 241 0.0374531068295944 246 17015724 SGTC_2863 9028737 58.44 µM 1.77889915743451 0.0438336318857658 no 242 0.0376281481422002 225 6460917 SGTC_1951 sophoraflavanone G 9.2 µM 1.77343465604721 0.0443239469408229 no 243 0.0380783553175306 318 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3209 9113616 49.47 µM 1.76593094381184 0.045004426681431 no 244 0.0387037175186537 323 16649353 SGTC_3089 9117425 49.47 µM 1.76512683995888 0.0450778435868059 no 245 0.0387712253641685 302 9401657 SGTC_1378 2093-0007 380 nM 1.76051618174428 0.0455006721386386 no 246 0.0391601631508971 320 3618014 SGTC_2487 5918373 44.05 µM 1.75650841552948 0.0458707971125205 no 247 0.0395008178754383 298 2876279 SGTC_113 0099-0221 2.5 µM 1.75357529697498 0.0461432065220564 no 248 0.0397516534750543 284 89219 SGTC_2218 6965428 192.983 µM 1.74872300299222 0.046596707987685 no 249 0.0401694559110421 274 675684 SGTC_3355 9151058 44.0485 µM 1.74837089646505 0.0466297550060192 no 250 0.0401999120330023 287 17015728 SGTC_548 1436-0017 110 µM 1.74704832993451 0.0467540527376803 no 251 0.0403144775247275 365 9677137 SGTC_1297 1068-0111 14.1 µM 1.74573854649612 0.0468774109139364 no 252 0.0404281968872545 274 767057 SGTC_1851 st056236 18.9 µM 1.74532663919935 0.0469162591269373 no 253 0.0404640137131868 304 5393171 SGTC_1923 st058458 19.1 µM 1.7430182361275 0.0471344495894899 no 254 0.0406652147170554 362 3534982 SGTC_3188 9110789 49.47 µM 1.7409724516453 0.0473284965529963 no 255 0.0408442037503273 301 849217 SGTC_2197 6588183 93.1375 µM 1.74005407193996 0.0474158147541807 no 256 0.0409247618982695 233 884136 SGTC_522 1273-0010 11.6 µM 1.73536581173296 0.0478635809424972 no 257 0.041338015821422 300 5705015 SGTC_1396 3511-0007 98.6 µM 1.73248546810909 0.0481403512853979 no 258 0.0415935811274492 276 X1396 SGTC_734 2023-0417 80 µM 1.72253889399438 0.0491059702001138 no 259 0.0424859717367008 332 3935732 SGTC_1873 rapamycin 2 nM 1.72245388521031 0.0491142890870833 no 260 0.0424936648007837 380 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1065 prochlorperazine maleate 2.48 µM 1.71726817236301 0.0496238908017802 no 261 0.0429650922770189 343 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_174 3553-0389 74.3 µM 1.7130088657845 0.0500456027073706 no 262 0.0433554542778025 274 738071 SGTC_256 clotrimazole 625 nM 1.71209463068591 0.050136492137457 no 263 0.043439615354869 322 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2390 9097792 176.6 µM 1.71062742794576 0.0502826303047882 no 264 0.0435749561928654 285 4497149 SGTC_1167 k781-0610 148 µM 1.71007279456957 0.050337961940363 no 265 0.0436262064201054 362 4525169 SGTC_84 0443-0269 128.823 µM 1.70854498371053 0.0504906311878422 no 266 0.0437676335205561 330 6150058 SGTC_1472 k841-0093 193 µM 1.70849319075108 0.0504958131500922 no 267 0.0437724343896057 355 X1472 SGTC_1192 1488-0095 21.4 µM 1.70590235121751 0.0507555716463318 no 268 0.0440131309691019 309 915875 SGTC_348 k064-0012 10.7 µM 1.70516537396054 0.0508296553159486 no 269 0.0440817929517929 285 5066323 SGTC_2940 9060638 45.86 µM 1.70124281263078 0.0512254153652918 no 270 0.0444487007970281 341 4027022 SGTC_3087 9117406 49.47 µM 1.70023178202068 0.0513278179310794 no 271 0.044543668167678 295 42546093 SGTC_775 4577-0580 57.3 µM 1.69812605886372 0.0515416195316888 no 272 0.0447419861161701 307 2006902 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.68845533505339 0.0525326316245847 no 273 0.0456619279900823 368 165506 SGTC_1414 3917-0015 5.4 µM 1.68791629002196 0.0525883124705636 no 274 0.0457136495613665 280 6618702 SGTC_689 0833-0039 98 µM 1.67838643360784 0.0535804568919755 no 275 0.0466358421465628 329 5374726 SGTC_3254 9136651 49.47 µM 1.67480403962312 0.0539572292799278 no 276 0.0469863430234113 355 16454030 SGTC_2346 9031566 143.75 µM 1.6688295931644 0.0545902444126211 no 277 0.0475755780509781 303 4771086 SGTC_1395 3486-0190 4.35 µM 1.66123204785658 0.0554036988995194 no 278 0.0483334257199942 338 6748079 SGTC_233 rapamycin 362 pM 1.65811521113141 0.0557401687213028 no 279 0.0486471071118375 335 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2989 9073649 71.4286 µM 1.64388716755183 0.0572966444514262 no 280 0.0500997556625511 454 21367202 SGTC_2897 9048598 12.99 µM 1.62641377213253 0.0592547074254119 no 281 0.0519308315149834 329 6467404 SGTC_187 1488-2104 32.728 µM 1.62319884263312 0.0596206210603128 no 282 0.0522734525946842 369 2852859 SGTC_245 methotrexate 289.6 µM 1.62206205808566 0.0597504294021698 no 283 0.0523950305602854 406 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_285 1486-1325 46 µM 1.61858997977557 0.0601482739526363 no 284 0.052767756241411 380 22310230 SGTC_3012 9080433 71.4286 µM 1.61612257297834 0.060432257646906 no 285 0.0530339073467736 356 17688859 SGTC_2560 caryophyllene 100 µM 1.6140342694006 0.0606734276741742 no 286 0.0532599966200672 403 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_470 aa-861 153 µM 1.61135478633104 0.0609839725744877 no 287 0.053551207971163 417 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2705 st078069 42.8 µM 1.6099734249733 0.0611445533311665 no 288 0.0537018290009949 332 1530061 SGTC_3343 9148379 18.9835 µM 1.60923569437086 0.061230448441592 no 289 0.053782407093242 353 1955036 SGTC_322 k048-0136 19.3 µM 1.60581458098772 0.0616300069512273 no 290 0.0541573279791848 342 6823282 SGTC_1073 triclabendazole 3.09 µM 1.60494506191827 0.0617318835630142 no 291 0.0542529477490075 423 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2724 maprotiline 69.64 µM 1.60234573417374 0.0620372161056479 no 292 0.05453958880548 337 4011 A tricyclic antidepressant. SGTC_2343 7990716 14.84 µM 1.60090239272281 0.0622072677095465 no 293 0.0546992697837295 374 6456862 SGTC_1317 1273-0028 910 nM 1.59673916758326 0.0626998078865146 no 294 0.0551619304920151 362 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1244 0416-0015 52.5 µM 1.5933211815908 0.0631064482993265 no 295 0.0555440786398627 383 96201 SGTC_990 3985-0011 41.3 µM 1.59226285701779 0.0632327735483225 no 296 0.0556628274799641 326 5399565 YGL099W LSG1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.58771364359452 0.063778026655284 no 297 0.056175553223584 406 688761 SGTC_2926 9010726 65.15 µM 1.58178204614398 0.0644944523832385 no 298 0.0568496675072762 398 2994293 SGTC_1107 amlodipine 47 µM 1.57654905182508 0.0651316769628459 no 299 0.0574496618200025 406 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1969 st069479 40.1 µM 1.57574615828967 0.0652298765860137 no 300 0.0575421575972234 337 3895485 SGTC_787 4152-0075 138 µM 1.57331681030118 0.0655277029279829 no 301 0.0578227394003911 388 9566539 SGTC_1781 st038725 66.3 µM 1.57295491307685 0.0655721598825062 no 302 0.0578646292487935 492 4270275 YIL048W NEO1 SGTC_3292 9120825 59.784 µM 1.57216429260909 0.0656693643317579 no 303 0.0579562270889506 373 24824900 SGTC_2852 9023854 51.95 µM 1.56748503653073 0.0662469538481512 no 304 0.0585006805581189 408 19798528 SGTC_2850 9015429 58.44 µM 1.5659172872236 0.0664413483083402 no 305 0.0586839910987347 364 6457570 SGTC_3196 9111891 49.47 µM 1.55894795216695 0.0673108668279588 no 306 0.059504349759981 341 18891510 SGTC_639 0833-0042 114 µM 1.55755289986242 0.0674859703810002 no 307 0.059669635639092 432 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_133 0724-0033 378.92 µM 1.55416261782995 0.0679129774638808 no 308 0.0600728159391751 360 280309 SGTC_809 3998-0021 90 µM 1.55296753302398 0.0680639951245252 no 309 0.0602154456387637 360 715485 SGTC_2862 9027634 71.43 µM 1.54777050436143 0.068723737728747 no 310 0.0608387801616597 382 5012562 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.5474427260804 0.0687655126483 no 311 0.0608782625916521 483 368090 SGTC_1279 0874-0590 65.2 µM 1.54604371666302 0.0689440347593064 no 312 0.0610470051094972 392 3523074 SGTC_1282 0886-0010 32.4 µM 1.54342969743937 0.0692785566103394 no 313 0.0613632764009985 435 2836211 YNL267W PIK1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.53646929964894 0.0701753917302846 no 314 0.0622116608660821 423 5357218 A potent inhibitor of glutathione S-transferases. SGTC_919 tnp00227 403.569 nM 1.53327023473563 0.0705905691791439 no 315 0.062604642656239 453 1269246 A methoxyflavone. YNL221C POP1 SGTC_354 2783-3500 4.88 µM 1.5315714551573 0.0708118043912476 no 316 0.0628141104886603 423 6740761 SGTC_1411 3909-8223 150 µM 1.53143137430987 0.0708300711278212 no 317 0.0628314074858533 405 X1411 SGTC_649 1123-0311 367 µM 1.53081498507345 0.0709104921533315 no 318 0.0629075625084407 465 693629 YIL048W NEO1 SGTC_1028 k015-0029 4.8 µM 1.52391060534281 0.0718161142193121 no 319 0.0637655219203123 458 4588309 SGTC_2362 9071156 126 µM 1.52284054545547 0.0719572604586696 no 320 0.0638993016786548 417 653133 SGTC_3260 9137109 49.47 µM 1.52233337053197 0.0720242336175023 no 321 0.063962785298628 300 17478346 SGTC_65 0798-0905 34.986 µM 1.52009191100991 0.0723207939319922 no 322 0.0642439386620292 538 3602145 SGTC_1807 st050092 58.9 µM 1.51704922186127 0.0727248584085644 no 323 0.0646271285585726 394 5008496 SGTC_1006 4099-6547 255 µM 1.51589601502476 0.0728784534738378 no 324 0.064772824059194 408 3146833 SGTC_493 zm226600 134 µM 1.5149798667679 0.0730006517302435 no 325 0.0648887514020094 432 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1704 st028805 70.8 µM 1.51130111755576 0.0734929125192128 no 326 0.0653558746816115 398 2876101 SGTC_792 4534-1957 155 µM 1.51013665860305 0.0736492588572846 no 327 0.0655042785799758 389 1717904 SGTC_1263 0774-1208 64.8 µM 1.50507766628762 0.0743314589593972 no 328 0.0661520550876856 491 906585 SGTC_1612 st002233 45.4 µM 1.50500741647802 0.0743409659287354 no 329 0.0661610849989382 418 1035021 SGTC_1090 efavirenz 20.7 µM 1.5036880586122 0.074519688316263 no 330 0.0663308526820659 413 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1016 4226-1401 38 µM 1.50270426471728 0.0746531679796797 no 331 0.0664576612469467 420 2901613 SGTC_2628 lathosterol 100 µM 1.50099752237924 0.0748851689416919 no 332 0.066678101199337 425 6710616 SGTC_2257 7960413 200 µM 1.49681970155047 0.0754553892819595 no 333 0.0672200892295525 484 2974689 YIL048W NEO1 SGTC_587 k089-0003 57 µM 1.49667497755898 0.0754752014341248 no 334 0.06723892511009 261 9659696 SGTC_2069 5228469 200 µM 1.49620888371489 0.0755390348137552 no 335 0.0672996151288002 392 2835210 SGTC_2213 7173844 200 µM 1.49565472245864 0.0756149828924227 no 336 0.0673718274888847 417 892728 SGTC_2006 4011487 200 µM 1.49160010345038 0.0761724415603611 no 337 0.0679020055379185 483 45595294 SGTC_3336 9143619 71.43 µM 1.4824771161559 0.0774381674913504 no 338 0.0691066940754944 452 45595730 SGTC_2892 9047358 58.44 µM 1.47913572286254 0.0779057287515168 no 339 0.0695520221908503 367 6466771 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.47629549111522 0.0783048442446787 no 340 0.0699322920232796 439 390807 SGTC_869 0564-0080 44.1 µM 1.47538471959193 0.0784331555988684 no 341 0.0700545705645248 461 6843321 SGTC_839 0122-0028 230 µM 1.47396547640119 0.0786334191288603 no 342 0.0702454433740117 506 759448 SGTC_2620 irigenin 100 µM 1.47241801749128 0.0788522160212883 no 343 0.0704540153256646 464 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_235 0330-0087 5 mM 1.47056293346482 0.0791151158737854 no 344 0.070704677169599 478 46494818 YHR062C RPP1 SGTC_3101 9120531 49.47 µM 1.46873506277383 0.0793748077883525 no 345 0.0709523316501073 459 24824904 SGTC_2728 chlorpromazine 9.18 µM 1.46751144058114 0.0795490122239623 no 346 0.0711184896840424 329 2726 A thorazine and dopamine antagonist. SGTC_1309 pyrazolanthrone 13.4 µM 1.46729349725703 0.0795800706722064 no 347 0.0711481159554136 453 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2928 9011484 9.79 µM 1.46575196437476 0.0798000119051355 no 348 0.0713579358880339 397 2994751 SGTC_106 0092-0003 11.579 µM 1.46074723971998 0.0805172405160178 no 349 0.0720424098708324 346 1072148 SGTC_1647 st011722 22.4 µM 1.46069936727577 0.0805241245663248 no 350 0.0720489813913804 411 2854783 SGTC_1657 st012939 43.4 µM 1.45706018168303 0.0810487414679339 no 351 0.0725498842506313 392 24207257 SGTC_377 3970-0964 33.1 µM 1.45705057354842 0.0810501299613286 no 352 0.0725512102499461 545 16481235 SGTC_667 1498-1044 59 µM 1.45227679138119 0.0817422227054738 no 353 0.0732123290086067 446 6739982 SGTC_2968 9090663 33.37 µM 1.4503446767857 0.0820235995198432 no 354 0.0734812131384934 449 25236811 SGTC_465 cgp-37157 41 µM 1.44484550819532 0.0828284458952656 no 355 0.0742506425881426 310 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2195 6536160 144.242 µM 1.4442747413489 0.0829123212775763 no 356 0.0743308539605782 394 3834386 SGTC_2736 butenafine 14.65 µM 1.44323923241546 0.0830646545723364 no 357 0.0744765456546673 501 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_535 2293-4129 48.2 µM 1.44089945012158 0.083409633993288 no 358 0.0748065457316547 543 396118 YIL048W NEO1 SGTC_1964 st076914 61 µM 1.44069854715102 0.0834393054206745 no 359 0.0748349327701319 419 24208661 SGTC_1212 0520-0165 585 µM 1.43990446432843 0.0835566614294642 no 360 0.0749472149367293 463 5403258 SGTC_2670 beta-carotene 100 µM 1.43793925319487 0.0838476295443938 no 361 0.0752256454561713 357 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2301 7769476 200 µM 1.43771823660189 0.0838804006901042 no 362 0.0752570082882232 404 977820 SGTC_1720 st037298 9.481 µM 1.43726792357253 0.0839472004358353 no 363 0.0753209397282705 430 597396 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.43612772629512 0.0841165167035041 no 364 0.0754829999136817 412 616764 SGTC_1611 st001856 99.4 µM 1.43433995570048 0.0843825118176504 no 365 0.0757376367002791 443 647478 SGTC_1648 st011736 69.8 µM 1.43406125323762 0.0844240356265707 no 366 0.0757773918964844 440 2855514 SGTC_1078 idebenone 36.1 µM 1.43373076535121 0.0844732947993554 no 367 0.0758245545620189 525 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1844 rapamycin 4 nM 1.4320280931491 0.0847274196182559 no 368 0.0760678907663797 608 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1207 2099-0101 141 µM 1.42741334323266 0.0854190558721949 no 369 0.0767303934995728 504 5837381 SGTC_1257 0669-0121 16 µM 1.42086166850185 0.0864082407390426 no 370 0.0776784892198523 528 4307855 SGTC_2648 atorvastatin 78.68 µM 1.41908302815328 0.0866782559495203 no 371 0.0779374056556791 431 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_555 4296-0685 37 µM 1.41828982567664 0.0867988750566767 no 372 0.0780530829563123 475 2908540 YHR072W ERG7 SGTC_2283 7944793 200 µM 1.4175443508866 0.0869123506929537 no 373 0.0781619185439323 484 2970533 SGTC_268 camptothecin 39.6153 µM 1.41540729145606 0.0872382665631384 no 374 0.0784745565051101 589 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1880 MG-132 525 µM 1.41328071987154 0.0875634879233053 no 375 0.0787866003009724 426 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_450 aminopyrene 156 nM 1.40850025487141 0.0882978766455976 no 376 0.0794914957746227 481 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2133 5320837 200 µM 1.40397494870053 0.0889972872776714 no 377 0.0801631547404956 445 2841355 SGTC_1830 st055982 50.3 µM 1.40366923934549 0.0890446846003771 no 378 0.0802086832205408 476 455313 An antimicrobial agent. SGTC_781 4335-2806 94.4 µM 1.40250946805816 0.0892246669325323 no 379 0.0803815825911385 533 845254 SGTC_2442 5158906 48.48 µM 1.40104004493302 0.0894530920116746 no 380 0.0806010492862958 485 1893835 SGTC_1706 st031321 9.9705 µM 1.3963821348215 0.0901800489824699 no 381 0.0812997259933877 471 6103185 SGTC_254 nsc-64875 3.808 µM 1.39409296972728 0.090538921763266 no 382 0.0816447659416027 466 56993 SGTC_1290 0986-0249 10.2 µM 1.3938806204526 0.0905722654530458 no 383 0.0816768286722694 432 53329 SGTC_3219 9131112 49.47 µM 1.39264682895469 0.0907661792847888 no 384 0.0818633073397343 458 17612988 YMR079W SEC14 SGTC_1531 st059297 52.4 µM 1.39146730271265 0.0909518521965206 no 385 0.0820418840451148 487 7566702 SGTC_3007 9078383 71.4286 µM 1.39039590243749 0.0911207487323554 no 386 0.0822043450316777 475 6496995 SGTC_1484 3473-2379 286 µM 1.3898065586529 0.0912137525418597 no 387 0.0822938129810079 581 671917 SGTC_387 norethindrone acetate 66.7 µM 1.383681993855 0.092184434376872 no 388 0.0832279247004969 443 541197 SGTC_590 k048-0076 22.4 µM 1.37732778259138 0.0931995731189107 no 389 0.0842054646700855 482 6832814 SGTC_207 4185-0010 4.486 µM 1.3717669150079 0.0940947260299469 no 390 0.0850680049256639 580 3761753 SGTC_2468 5987765 72.9 µM 1.36987424230345 0.0944008387149836 no 391 0.0853630807358576 496 26772094 SGTC_3098 9119039 49.47 µM 1.36979879800231 0.0944130559510454 no 392 0.0853748586968416 491 17161528 SGTC_1302 1159-0335 255 µM 1.36875737100071 0.0945818208296467 no 393 0.0855375651113054 478 649284 SGTC_2771 fluoxetine 41.05 µM 1.36763713576478 0.0947636048552697 no 394 0.0857128431708505 465 3386 A selective serotonin reuptake inhibitor. SGTC_657 3534-0529 86.7 µM 1.36251118916687 0.0955986932149906 no 395 0.0865183077005744 499 1049549 SGTC_797 k781-0471 270 µM 1.36111645375918 0.0958268495244717 no 396 0.086738445365046 505 23738129 SGTC_3189 9110682 49.47 µM 1.35810677244318 0.0963205492582963 no 397 0.0872149032785063 503 17122418 SGTC_396 dithiazanine 1.25 µM 1.35776701275507 0.0963763997028386 no 398 0.0872688126179669 460 10578 An antihelmenthic. SGTC_2765 myclobutanil 7.74 µM 1.35636477178542 0.0966071549559072 no 399 0.0874915680709273 526 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_249 wiskostatin 11.211 µM 1.35575261962512 0.096708018961158 no 400 0.0875889455308606 497 2775510 A n-wasp and actin depolymerizer. SGTC_1604 st002052 72.4 µM 1.35282609489309 0.0971912898301779 no 401 0.0880555970804223 511 6254834 YHR062C RPP1 SGTC_531 3788-1495 174 µM 1.35088324301869 0.0975130994795935 no 402 0.088366418422679 499 2896655 SGTC_952 1185-0122 232 µM 1.35058062569484 0.097563294598053 no 403 0.0884149052490774 522 678600 SGTC_270 tamoxifen 5.46 µM 1.3496972335163 0.0977099311962901 no 404 0.0885565600578886 551 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1960 st011366 51.8 µM 1.34905132261303 0.0978172498712833 no 405 0.088660240923718 478 3972846 SGTC_2052 5265182 7.135 µM 1.34514787950956 0.0984676497789444 no 406 0.089288741915536 522 1239884 SGTC_2365 9042475 200 µM 1.34277729691705 0.0988641835279362 no 407 0.0896720484268912 537 6464479 SGTC_1867 st057372 64 µM 1.34277502597797 0.0988645639534039 no 408 0.0896724162073834 519 688837 SGTC_2576 guaiol 23.12 µM 1.34069707598128 0.0992131091122538 no 409 0.0900094121544267 559 227829 SGTC_1973 st070275 50.2 µM 1.33971749791015 0.09937773002699 no 410 0.090168603299733 465 17118334 SGTC_2233 sulbentine 40.3845 µM 1.33825477274601 0.0996239167633145 no 411 0.0904066998173863 568 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1339 1486-1321 22.7 µM 1.3336605508975 0.100400053533351 no 412 0.0911575644551734 529 3469382 SGTC_3341 9147222 25.867 µM 1.33249766864593 0.10059720598209 no 413 0.0913483535220902 498 1939759 SGTC_656 4090-1979 187 µM 1.33149824686227 0.100766871238549 no 414 0.0915125607335302 568 22330961 SGTC_1328 1441-0025 69.2 µM 1.33055330515954 0.100927479607762 no 415 0.0916680178511508 473 4562601 SGTC_296 1222-0039 74.9 µM 1.32986785815292 0.10104409932332 no 416 0.0917809065735439 496 5984176 SGTC_2819 7996655 46.38 µM 1.32751845729725 0.101444563957489 no 417 0.0921686192376071 457 6456960 SGTC_571 k831-0106 44.2 µM 1.32717225640194 0.101503672857488 no 418 0.0922258537941466 500 4783639 SGTC_2415 st077333 57.7 µM 1.32628840441028 0.101654691826055 no 419 0.092372093109364 615 2766255 SGTC_1850 st056238 17 µM 1.32464993125559 0.101935081423409 no 420 0.0926436434062939 588 5393177 SGTC_2412 st077135 33.4 µM 1.32217299804137 0.102360023423949 no 421 0.0930552751704046 538 13258915 SGTC_2997 9067075 71.4286 µM 1.32122301269638 0.102523343983515 no 422 0.0932135076346342 573 27209819 SGTC_1588 farnesol 29.9 µM 1.31361041826089 0.103838939601454 no 423 0.0944886704644777 535 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1155 4088-0394 48.2 µM 1.31286924867297 0.103967678441975 no 424 0.0946135052960303 540 2326248 SGTC_3220 9131269 49.47 µM 1.31127882745563 0.104244320215583 no 425 0.0948817894188896 503 17722206 SGTC_3300 9124615 50.48 µM 1.31025415896437 0.104422835949034 no 426 0.0950549347860795 528 24824903 SGTC_2624 nerol 100 µM 1.30913715681695 0.104617690108058 no 427 0.0952439474215921 517 637566 A natural product oil. SGTC_298 1391-0729 10 µM 1.30448635127282 0.105431825782663 no 428 0.0960339050770053 504 3237558 SGTC_1523 st012844 44.7 µM 1.30328236874778 0.105643330822923 no 429 0.0962391890815954 548 4274103 SGTC_3178 9107506 49.47 µM 1.29566737090936 0.106988175592717 no 430 0.0975450537003268 554 8897194 SGTC_562 3772-2733 112 µM 1.29426006533049 0.10723805849193 no 431 0.0977878027579957 633 2876874 YIL048W NEO1 SGTC_3092 9117248 49.47 µM 1.2937582092213 0.107327270385791 no 432 0.0978744759900299 570 17141857 SGTC_500 h-89 112 µM 1.29254799841392 0.107542622210446 no 433 0.0980837174460841 590 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2653 dihydrofissinolide 100 µM 1.29150130115709 0.107729128474938 no 434 0.0982649521078835 513 6857746 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.29133060740271 0.107759565709964 no 435 0.0982945308202266 514 2374 Ca(2+)-ATPase inhibitor. SGTC_1885 st057546 99.9 µM 1.29088744969488 0.107838616237754 no 436 0.0983713539617561 579 702008 SGTC_2181 6316240 54.2555 µM 1.28995976690478 0.108004231624534 no 437 0.0985323137867353 501 12779990 SGTC_2779 methotrexate 400 µM 1.28897406099057 0.108180406238337 no 438 0.0987035522455707 565 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2789 5281112 71.43 µM 1.28505074297564 0.10888366854467 no 439 0.0993872763180952 554 765948 SGTC_826 1683-5028 118 µM 1.28263251322778 0.10931877486706 no 440 0.0998104268588486 539 722377 SGTC_936 3005-4620 401 µM 1.27035177476024 0.111547700635547 no 441 0.101979676633851 626 777207 SGTC_274 sirtinol 40.1 µM 1.26971633749242 0.11166390947955 no 442 0.102092845557034 557 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2188 6126565 140.678 µM 1.267870623362 0.112001944978552 no 443 0.102422078208943 508 874518 SGTC_253 dyclonine 31.25 µM 1.26663534667309 0.112228589500502 no 444 0.102642853787709 619 3180 An oral anasthetic. SGTC_2777 climbazole 1.536 µM 1.26339192239179 0.112825242053754 no 445 0.10322418281568 610 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1361 1608-0041 5.61 µM 1.26187788416557 0.113104534855157 no 446 0.103496365576716 581 X1361 SGTC_2177 5811945 192 µM 1.26079480637404 0.113304631368471 no 447 0.103691392746643 567 5343475 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.26074961140489 0.113312986535893 no 448 0.103699536685598 614 5379071 SGTC_2134 5324836 1.464 µM 1.25938368240569 0.113565712418196 no 449 0.10394589021035 502 699272 SGTC_1792 st045773 43.6 µM 1.25274273615549 0.114800155350033 no 450 0.105149673810212 570 2919270 SGTC_433 pimozide 108 µM 1.25115655703229 0.115096407102511 no 451 0.105438682253587 459 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_636 0kpi-0074 126 µM 1.24869189418887 0.115557811740822 no 452 0.105888893371578 538 616434 SGTC_3029 9088683 49.47 µM 1.24394187022763 0.116450757931448 no 453 0.106760478937952 567 25236615 SGTC_2947 9072639 7.68 µM 1.24358332011644 0.116518359077539 no 454 0.106826479100415 631 16488146 SGTC_2268 7933382 153.85 µM 1.24199545164901 0.116818070839226 no 455 0.107119120101196 663 935025 YOR257W CDC31 SGTC_1024 4507-0395 26 µM 1.23993551707024 0.117207699331987 no 456 0.107499622849056 570 4201836 SGTC_1223 0764-0573 147 µM 1.2368055612411 0.117801478670256 no 457 0.108079638483901 628 1609797 SGTC_2141 5621638 7.665 µM 1.23562126465054 0.118026703990112 no 458 0.1082996883048 573 2856238 SGTC_480 am 92016 50 µM 1.23394050497217 0.118346867514717 no 459 0.108612537344058 537 2129 K+ channel blocker. SGTC_1247 0448-0043 5.84 µM 1.23280436380768 0.118563635567005 no 460 0.108824381432016 641 3089013 YGL099W LSG1 SGTC_544 k015-0020 52.4 µM 1.22858412703795 0.119371284457356 no 461 0.109613884877526 576 3008304 SGTC_2706 st078239 82.5 µM 1.22501108263656 0.120058105302051 no 462 0.110285522430076 605 15434492 SGTC_628 1636-0253 16 µM 1.21931195904822 0.12115936263523 no 463 0.11136290564293 649 4456143 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.21623226355267 0.121757409043561 no 464 0.111948228276819 637 442882 SGTC_107 0358-0022 2.6945 µM 1.21593396055339 0.121815446525696 no 465 0.112005039968665 448 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1516 st013856 110 µM 1.2158439945731 0.121832954015579 no 466 0.112022178000302 574 5281404 A mutagen and neurotoxin. SGTC_313 3474-0040 5.03 µM 1.2144089766669 0.12211244924983 no 467 0.112295794619328 658 1043375 YIL048W NEO1 SGTC_2598 perillyl alcohol 100 µM 1.21345806216158 0.12229790458367 no 468 0.112477369538909 623 10819 An apoptosis inducer. SGTC_1259 0671-0132 43 µM 1.21231588451822 0.122520922901869 no 469 0.112695742846863 610 X1259 SGTC_2360 9040895 200 µM 1.21076326466684 0.122824540350049 no 470 0.112993073982692 564 4914414 SGTC_2612 dictamnine 15.46 µM 1.21070957722836 0.122835048449318 no 471 0.113003365285799 596 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2499 avocadenofuran 51.48 µM 1.21020759822146 0.122933329968043 no 472 0.113099621619462 606 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_237 nikkomycin 200 µM 1.21018504856732 0.122937746215733 no 473 0.113103946971895 643 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3243 9134147 49.47 µM 1.20847607869112 0.123272763939368 no 474 0.113432095840595 630 24282180 SGTC_194 1486-1323 56.904 µM 1.20654533330581 0.123652026419506 no 475 0.113803645267716 603 5178754 SGTC_1234 0326-0494 15.5 µM 1.2031931296687 0.124312449747634 no 476 0.114450796464684 609 1547813 SGTC_1828 st055811 49 µM 1.20188124864543 0.124571576091379 no 477 0.114704770219719 563 5877589 SGTC_2715 st079500 56.4 µM 1.20155813125354 0.124635457039036 no 478 0.114767385670277 577 28246688 SGTC_1550 gossypolone 36.6 µM 1.20088738269749 0.124768138448573 no 479 0.114897444613321 639 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2825 7998094 58.44 µM 1.19848200578816 0.125244759879976 no 480 0.11536471205743 600 2987815 SGTC_318 1488-0629 67.2 µM 1.19723659751368 0.125492034328602 no 481 0.115607174477132 582 3662576 SGTC_1968 st069590 43.6 µM 1.19658639354478 0.12562126690165 no 482 0.115733903233058 601 6384066 SGTC_3278 9139605 49.47 µM 1.19627746296822 0.125682701538026 no 483 0.115794150268651 616 7958859 SGTC_2921 7974240 10.71 µM 1.19619350150668 0.125699401926934 no 484 0.115810528116893 621 2979074 YDR527W RBA50 SGTC_213 1246-0773 967 nM 1.19602561894334 0.125732799319368 no 485 0.115843280873654 650 6251622 SGTC_3312 9133330 71.43 µM 1.19582083941353 0.125773545117943 no 486 0.115883240884236 666 17617324 SGTC_641 4092-0595 30 µM 1.19452874250433 0.126030851191589 no 487 0.116135602185225 655 786260 SGTC_2992 9074591 71.4286 µM 1.19445160491143 0.126046223847019 no 488 0.116150680367663 614 17741321 SGTC_1846 st056244 14.8 µM 1.19373570713874 0.126188956597127 no 489 0.116290684092385 669 5393182 SGTC_1667 st014849 34.6 µM 1.19004714337989 0.126926152683419 no 490 0.11701393164245 657 5348460 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.18636196857306 0.127665659859578 no 491 0.117739692023947 623 7104 SGTC_2208 7283366 200 µM 1.18618117506951 0.127702016761466 no 492 0.117775379394561 646 898663 SGTC_3330 9141424 71.43 µM 1.18583107925999 0.127772440188494 no 493 0.11784450761591 673 27261020 SGTC_54 0159-0055 9 µM 1.18576496550454 0.127785742312273 no 494 0.11785756533967 623 3319099 SGTC_1840 st055363 71 µM 1.18518149435869 0.127903178754913 no 495 0.117972847545204 570 676033 SGTC_1261 0712-0010 12.7 µM 1.184500985801 0.128040240829112 no 496 0.118107403144339 670 2840123 SGTC_2630 antimycin a 100 µM 1.18298496259229 0.128345951697421 no 497 0.118407553539427 667 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1007 4101-0031 70 µM 1.18076617744676 0.128794289720325 no 498 0.118847811887814 653 1146276 SGTC_2999 9069765 71.4286 µM 1.17647402206578 0.129664663477961 no 499 0.119702753691959 668 2097066 SGTC_208 k072-0098 12.366 µM 1.17476210162599 0.13001294478277 no 500 0.120044953117699 730 5948901 SGTC_2425 5628681 7.85 µM 1.17375056562765 0.130219040592583 no 501 0.120247474963141 736 5714958 SGTC_1996 st072960 66.8 µM 1.17347575878165 0.130275070250987 no 502 0.120302536202761 685 1719405 SGTC_3168 9103419 49.47 µM 1.17344604550328 0.13028112941366 no 503 0.120308490720716 536 16649256 SGTC_3023 9089636 49.47 µM 1.17175278729698 0.130626742563319 no 504 0.120648161448437 693 17249241 SGTC_3149 9097855 49.47 µM 1.17154108474665 0.130669997989358 no 505 0.120690676808383 623 25236625 YMR079W SEC14 SGTC_488 nitrendipine 139 µM 1.16734496050711 0.131529400965377 no 506 0.1215355443191 672 4507 Dihydropyridine L-type calcium channel blocker. SGTC_822 1487-0950 154 µM 1.16591402537322 0.131823359100017 no 507 0.121824603880016 644 1958375 SGTC_2929 9013348 24.6 µM 1.16091577128332 0.132853709391313 no 508 0.122838077229879 633 2995952 SGTC_172 1112-0046 2.638 µM 1.15931154755371 0.133185579760935 no 509 0.123164608237352 577 2802135 YIL048W NEO1 SGTC_195 4234-0266 16.654 µM 1.15929491826413 0.1331890228947 no 510 0.123167996221327 703 2303354 SGTC_1342 1486-1464 234 µM 1.15867727935564 0.133316949881896 no 511 0.123293877732861 676 3253938 SGTC_2355 9061122 103.12 µM 1.15606399121058 0.133859156335254 no 512 0.123827491717734 653 5302957 SGTC_2941 9056145 11.23 µM 1.1556088379994 0.133953746530369 no 513 0.123920595671485 558 2119517 SGTC_860 0443-0016 25.1 µM 1.15493283414318 0.134094318783613 no 514 0.124058966175795 661 5337942 SGTC_750 4073-0104 132 µM 1.15418993960262 0.134248917529591 no 515 0.124211153106684 542 22330957 SGTC_2304 7443016 91.4 µM 1.15169710653424 0.134768578482057 no 516 0.124722780846288 591 939854 SGTC_2372 9071633 200 µM 1.1516932893603 0.134769375274663 no 517 0.124723565408738 725 21321366 SGTC_850 0388-0143 75.9 µM 1.14765355643348 0.13561443691582 no 518 0.125555805572441 643 67273 SGTC_429 1112-0049 25.5 µM 1.14659320424541 0.135836849527685 no 519 0.125774893214444 631 2836170 SGTC_1276 0871-0068 94.2 µM 1.14469199773261 0.136236259465243 no 520 0.126168383743706 649 3414906 SGTC_3071 9117417 49.47 µM 1.14207809876065 0.136786704343582 no 521 0.12671077906715 572 45595590 YGL055W OLE1 SGTC_904 1141-0088 396 µM 1.13839570452973 0.13756473346287 no 522 0.127477643446627 650 1378119 SGTC_183 3914-0051 30.55 µM 1.13732416210539 0.137791698989376 no 523 0.1277013987982 671 1596232 SGTC_1059 3448-6867 171 µM 1.12758675210078 0.139865909101962 no 524 0.129747242086737 689 3934407 SGTC_1606 st000094 49.2 µM 1.12750486941287 0.139883440812659 no 525 0.129764541442763 725 1242210 SGTC_2363 9053361 176 µM 1.12695893616003 0.140000367479179 no 526 0.129879921590534 684 6469797 YMR079W SEC14 SGTC_3304 9125678 46.087 µM 1.12507938573911 0.140403432880007 no 527 0.130277697903766 689 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_884 0851-0618 334 µM 1.12276112477102 0.140901663081804 no 528 0.130769480015716 710 9642473 SGTC_1300 1094-0077 113 µM 1.12147461519819 0.141178670778649 no 529 0.131042945468945 650 5532636 SGTC_543 3844-1095 191 µM 1.12025177244723 0.141442311976736 no 530 0.131303243665611 735 4230703 SGTC_1120 ficusin 1.78878 µM 1.11814387723724 0.14189755062302 no 531 0.13175277466954 702 6199 A DNA cross-linker. SGTC_1382 3002-2117 298 µM 1.11451335334953 0.14268395249872 no 532 0.132529509525855 748 1497314 SGTC_1698 5-fluorocytosine 1.055 µM 1.11417118917339 0.142758219773614 no 533 0.13260287641911 696 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_505 gw-5074 63.9 µM 1.11405816885227 0.142782756753215 no 534 0.132627116399285 704 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2147 5545932 89.7195 µM 1.11342099495208 0.142921142056666 no 535 0.132763831083845 664 797404 SGTC_1916 st067606 49.2 µM 1.11192110005914 0.143247256068007 no 536 0.133086037818427 735 19590279 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.10858351249446 0.143974731847275 no 537 0.133804946988752 706 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3326 9140064 16.379 µM 1.10793126078186 0.144117190150149 no 538 0.133945751826623 681 1868434 SGTC_2100 5377183 190 µM 1.10641349947481 0.144449052210543 no 539 0.13427379258128 750 2844202 SGTC_3258 9138477 49.47 µM 1.10574944877213 0.14459441026181 no 540 0.134417490292179 693 4970355 SGTC_626 0214-0009 33 µM 1.10547911055471 0.144653614433894 no 541 0.134476020549046 721 3437874 SGTC_2119 5528445 120.635 µM 1.1043903820945 0.144892211660942 no 542 0.134711915557097 702 791935 SGTC_956 1185-0240 191 µM 1.10284957869554 0.145230334723499 no 543 0.13504624678598 681 1416193 SGTC_2523 spermine 47.74 µM 1.09545774080108 0.146859822568754 no 544 0.136658074822045 692 1103 A DNA binding polyamine. SGTC_516 3992-2719 87.3 µM 1.09286006712595 0.147435365759943 no 545 0.137227621790045 654 5350887 YDR037W KRS1 SGTC_209 4077-0173 175.592 µM 1.09157662473293 0.147720283626706 no 546 0.137509617579277 593 15993494 SGTC_1032 k061-1018 98.7 µM 1.08948848014791 0.148184628911583 no 547 0.137969266080455 803 4005393 SGTC_835 0312-0010 67.2 µM 1.08670929466471 0.148804155842189 no 548 0.138582652495041 677 1626196 SGTC_2237 6667747 47.222 µM 1.0840914417455 0.149389300018136 no 549 0.13916212852714 686 729940 YDL015C TSC13 SGTC_2045 5106652 78.05 µM 1.08270006568258 0.149700925610513 no 550 0.139470787435566 731 673349 SGTC_13 0199-0087 65 µM 1.07803630538163 0.150748626151925 no 551 0.140508777242144 740 4589825 SGTC_1042 0350-0096 82 µM 1.07080303454059 0.152383195724179 no 552 0.142129001097619 702 3122515 SGTC_2102 5377816 72.7585 µM 1.06828885681623 0.152954092734222 no 553 0.142695116710426 774 1379702 SGTC_837 0091-0265 12.5 µM 1.06793429507138 0.153034717390334 no 554 0.14277507561449 763 759367 SGTC_528 3492-0019 172 µM 1.06605884810992 0.153461648371786 no 555 0.1431985203177 906 2869262 SGTC_2972 9093619 59.92 µM 1.062928687873 0.154175960588138 no 556 0.143907146050129 715 25236256 SGTC_2495 cafestol 54.53 µM 1.06157489263963 0.154485581008665 no 557 0.144214358416258 681 16667697 An anti-infammatory. SGTC_1507 4075-3230 155 µM 1.06036656570085 0.154762278941738 no 558 0.144488933297985 666 659771 SGTC_36 0335-0881 14.2 µM 1.05726845607 0.155473218254391 no 559 0.145194542582207 792 23828853 SGTC_2101 5377231 179.231 µM 1.0551509098529 0.155960380323261 no 560 0.145678155724218 732 2844213 SGTC_880 0833-0487 87.2 µM 1.05426300627425 0.156164950240457 no 561 0.145881260349405 723 76075 SGTC_764 1951-2361 146 µM 1.05368263797902 0.156298760596472 no 562 0.146014120225183 724 5438930 SGTC_774 k060-0086 136 µM 1.05317475339559 0.156415920974638 no 563 0.146130453564308 838 5911235 SGTC_2267 7931562 200 µM 1.04890497254181 0.157403173593126 no 564 0.147110928352557 678 934880 SGTC_1723 st034307 2.5525 µM 1.04671161769067 0.157911906886614 no 565 0.147616301933949 740 867466 SGTC_1458 k015-0034 6.33 µM 1.04639055286951 0.157986466110847 no 566 0.147690376328353 709 3598957 SGTC_18 0111-0177 500 nM 1.04464660349882 0.158391858125774 no 567 0.148093165993669 851 721752 SGTC_441 propafenone 146 µM 1.04346840248169 0.158666124284094 no 568 0.148365703823521 702 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2519 cryptotanshinone 88.04 µM 1.03937810417821 0.159620695136481 no 569 0.149314461586187 759 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2429 5902844 64.44 µM 1.0375400426553 0.160050873008681 no 570 0.149742122074572 794 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_702 1488-0190 94 µM 1.03288159846979 0.161144522187014 no 571 0.15082965562743 767 949357 SGTC_1767 st044992 70.3 µM 1.03019358060985 0.161777793475195 no 572 0.151459571284471 750 9600693 SGTC_201 4262-0159 12.803 µM 1.0297703262635 0.161877655734283 no 573 0.151558916751831 702 1341029 SGTC_927 2425-1185 123 µM 1.02765391822744 0.162377601553163 no 574 0.15205632582406 764 730375 SGTC_2546 rhodinyl acetate 100 µM 1.02700533680277 0.162531012850995 no 575 0.152208975552518 806 6708682 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.01769153942096 0.164744435705465 no 576 0.154412284628752 865 65057 A dermal irritant. YDR527W RBA50 SGTC_1897 st060201 15 µM 1.01394477448513 0.165640336075027 no 577 0.155304552404278 728 611878 SGTC_1236 0330-0013 258 µM 1.01264873964387 0.165950966923922 no 578 0.15561398524321 761 4617066 SGTC_203 k066-0004 30.888 µM 1.01111444471793 0.166319189759443 no 579 0.15598082881185 933 6795412 SGTC_794 k038-0031 316 µM 1.01075377985522 0.166405823992331 no 580 0.156067144964245 862 6624242 SGTC_2149 5554786 194.827 µM 1.00921563774362 0.166775623566317 no 581 0.156435614286864 815 745063 YPR165W RHO1 SGTC_2833 9001315 45.46 µM 1.00885985218143 0.166861236851848 no 582 0.156520925941602 789 2989378 SGTC_2711 st079103 59.1 µM 1.00856604389858 0.166931957808138 no 583 0.156591399530675 771 54693780 SGTC_7 0192-1582 4.227 µM 1.00757046237995 0.16717174241575 no 584 0.156830357499366 898 252616 SGTC_3207 9114163 49.47 µM 1.00684488555794 0.167346636530842 no 585 0.15700466043119 846 849233 SGTC_2068 5226020 147 µM 1.0065939049063 0.167407160718548 no 586 0.157064982338768 827 1810509 SGTC_2070 5230947 200 µM 1.00514503117216 0.167756833497587 no 587 0.157413509642299 848 2835538 SGTC_3090 9117696 49.47 µM 1.00250695161728 0.168394717332768 no 588 0.158049405401075 795 7923821 SGTC_1906 st060206 94.7 µM 1.00194645588264 0.168530445040686 no 589 0.158184726967094 854 5133468 SGTC_630 4356-0227 183 µM 1.0008575666149 0.168794327682384 no 590 0.15844783689143 760 779312 SGTC_2086 5274770 176.623 µM 1.00026620623824 0.168937749804201 no 591 0.158590848388838 799 689278 SGTC_2089 5281248 129.67 µM 1.00014238617817 0.168967789685181 no 592 0.1586208030976 806 2737878 SGTC_833 3852-0053 558 µM 0.998048599162415 0.169476281105716 no 593 0.159127896513715 877 3123681 SGTC_88 0180-0332 8.668 µM 0.996729125261478 0.169797228799644 no 594 0.159448004236044 801 3101745 SGTC_2801 7907800 81.82 µM 0.990136534333227 0.171406638680833 no 595 0.161053694092362 805 6620925 SGTC_415 dibenzyl ketone 100 µM 0.989796100900235 0.171490010565777 no 596 0.161136895512808 824 7593 SGTC_389 tpck 16.7 µM 0.987517873221869 0.172048613621355 no 597 0.161694412642352 815 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_776 4476-4378 112 µM 0.987498985656385 0.172053249549355 no 598 0.161699039966727 779 2892008 SGTC_1712 st032288 53.4 µM 0.987342459451904 0.172091671768012 no 599 0.161737391137725 915 2883011 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.986698459456177 0.172249810955053 no 600 0.161895242759978 761 5282362 SGTC_529 4076-0302 30.3 µM 0.984948641487474 0.172679960378898 no 601 0.16232464945225 797 5816522 SGTC_259 usnic acid 108.925 µM 0.984712500998929 0.172738062070544 no 602 0.162382655237894 838 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2439 5492030 7.2 µM 0.983435259547052 0.173052539625345 no 603 0.162696631906492 797 5722370 SGTC_2483 5729050 27.16 µM 0.982235926346439 0.173348166706162 no 604 0.162991816109531 914 2865180 SGTC_2344 7990960 76.95 µM 0.980794838832176 0.173703809496091 no 605 0.163346961965249 776 140813 SGTC_1413 3910-0535 34.4 µM 0.979930328207592 0.173917382749152 no 606 0.163560255574329 869 2876951 SGTC_2227 7312221 64.1025 µM 0.97903224688493 0.174139426239087 no 607 0.16378202324227 851 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1999 st074831 12.5 µM 0.974914069609551 0.175159919063358 no 608 0.16480144321895 828 17112523 SGTC_3224 9130643 49.47 µM 0.973886357964197 0.175415178355535 no 609 0.165056484006182 782 17644395 SGTC_1909 st060837 51.5 µM 0.972528558335749 0.175752785097752 no 610 0.165393832274092 782 678937 SGTC_589 1227-0070 34.1 µM 0.966927474645268 0.177149800013994 no 611 0.16679014538552 834 2841384 SGTC_1425 4048-4433 7.33 µM 0.962537249135112 0.178249693932099 no 612 0.167889900729972 895 23734946 SGTC_3116 9124943 49.47 µM 0.96245730400483 0.178269762597721 no 613 0.167909970234814 772 41905195 YPL160W CDC60 SGTC_1643 st009866 20.2 µM 0.960566613217131 0.178744798629753 no 614 0.168385061237216 849 3156273 YOR207C RET1 SGTC_3016 9080866 49.47 µM 0.958494547912085 0.179266319363792 no 615 0.16890671970937 860 17066299 SGTC_2435 5706476 10.6 µM 0.957761562490577 0.179451034287981 no 616 0.169091502788666 892 5725375 SGTC_1441 4106-0040 13 µM 0.957462218829611 0.179526504348437 no 617 0.169167003605944 852 2904180 SGTC_1253 0550-0034 176 µM 0.954372005048561 0.180306769899082 no 618 0.169947685860223 779 5969915 SGTC_1914 st062367 72.6 µM 0.951689300365353 0.180985864030272 no 619 0.170627288654566 807 978205 SGTC_622 1348-1566 26.3 µM 0.948401555961838 0.181820299129228 no 620 0.171462533810877 908 7340407 SGTC_2328 6201408 200 µM 0.948344487300702 0.181834804468046 no 621 0.171477055028975 815 2890418 SGTC_1785 bathophenanthroline 24 µM 0.947806955912361 0.181971466194153 no 622 0.171613869370286 824 72812 An iron chelator. SGTC_1742 st038235 28.8875 µM 0.947671288850202 0.182005968272078 no 623 0.171648410837711 831 564103 YBR002C RER2 SGTC_973 1325-0077 65.9 µM 0.947540915466885 0.182039127945381 no 624 0.171681608694434 922 2835149 SGTC_963 1269-2853 151 µM 0.94679820884472 0.18222810287896 no 625 0.171870807337695 823 3668223 SGTC_2774 tamoxifen 10.92 µM 0.945276360201199 0.182615706235134 no 626 0.172258901995197 857 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_586 0957-0265 8.15 µM 0.940284662194854 0.183890664122835 no 627 0.173535782424939 793 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1125 tnp00248 1.32998 µM 0.939337288672104 0.184133262592143 no 628 0.173778799709448 988 24207736 SGTC_2553 4-methylesculetin 85.09 µM 0.938542677108491 0.184336896124367 no 629 0.173982797816362 881 5319502 SGTC_398 bronopol 33.3 µM 0.935697388385135 0.185067201117697 no 630 0.174714507825958 877 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2881 9058953 51.95 µM 0.931488686146849 0.186150746167442 no 631 0.175800417164091 939 17122249 SGTC_2036 5160441 105 µM 0.928822399792173 0.186839221110266 no 632 0.176490566956606 935 134534 YIL048W NEO1 SGTC_1163 k060-0048 49.9 µM 0.928593932318074 0.186898288033957 no 633 0.176549783792558 906 6809982 SGTC_2203 7227154 166.4 µM 0.92702489346456 0.187304252183201 no 634 0.176956804806272 889 896304 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.926678364149936 0.18739398464327 no 635 0.177046777112312 905 688751 SGTC_1159 4092-0538 61.2 µM 0.921989743758974 0.188610695942451 no 636 0.178266962728087 934 717301 SGTC_862 0452-0056 10.2 µM 0.9203771150059 0.189030301172336 no 637 0.178687861722843 874 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2480 5767542 37.17 µM 0.919968694527676 0.189136663171178 no 638 0.178794559423236 915 2867358 SGTC_320 4092-0846 5.34 µM 0.919081285933206 0.189367891592129 no 639 0.179026528455653 901 1359356 SGTC_1937 st074714 47.2 µM 0.918552552051597 0.189505744296632 no 640 0.179164829728978 879 17250970 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.918526521630463 0.189512532601908 no 641 0.179171640258844 808 521171 SGTC_670 4204-0025 119 µM 0.916552438207998 0.190027776924476 no 642 0.17968860856654 930 719039 SGTC_1160 4092-0570 10.5 µM 0.9132446849085 0.190893042644808 no 643 0.180556933663286 889 4994975 SGTC_1289 0976-0073 69.1 µM 0.91287749727065 0.190989243031505 no 644 0.180653486866013 924 3391136 SGTC_824 1304-0008 100 µM 0.91275931642411 0.191020211844599 no 645 0.18068456979601 896 768245 SGTC_385 1494-0393 12.4 µM 0.912519609070585 0.191083035645435 no 646 0.180747625901343 912 3090647 SGTC_1670 st016595 4.04 µM 0.911798402886075 0.191272129661758 no 647 0.180937425638941 940 597879 SGTC_2879 9041815 71.43 µM 0.909855338867612 0.191782154751348 no 648 0.181449402813306 817 4942971 SGTC_998 3996-0085 177 µM 0.908737751683594 0.192075881429267 no 649 0.181744285821303 958 715391 SGTC_2531 methyl deoxycholate 70.07 µM 0.907466691934615 0.192410278461872 no 650 0.182080027789074 865 16667744 Haematoxylin. SGTC_1654 st012436 41.8 µM 0.903701020371671 0.193403058606983 no 651 0.183076978961763 868 4323132 SGTC_926 2268-1401 59.4 µM 0.903215301058044 0.193531340625406 no 652 0.183205819313436 911 2931578 SGTC_2190 6049624 200 µM 0.902388238855997 0.193749893183305 no 653 0.183425333277892 852 2265554 SGTC_1303 1160-0052 261 µM 0.901710383871709 0.193929129637731 no 654 0.183605367752967 952 3562476 SGTC_2927 9011802 47.9 µM 0.90163198715518 0.193949865587865 no 655 0.18362619658222 858 43912568 SGTC_3039 9090270 49.47 µM 0.89765252644184 0.195004208142099 no 656 0.184685413159514 903 17173750 SGTC_2391 6285546 200 µM 0.897482800298171 0.195049253764646 no 657 0.184730673620703 927 846083 SGTC_757 1066-0008 322 µM 0.897032002909208 0.195168926908022 no 658 0.184850920148407 928 6842497 SGTC_602 3130-1533 38.1 µM 0.896189148673997 0.195392799030854 no 659 0.185075875114115 967 720941 SGTC_1957 st077035 62.4 µM 0.895297464430332 0.195629810717466 no 660 0.18531404768713 944 705593 SGTC_378 3970-0959 8.33 µM 0.895083066262655 0.195686824254024 no 661 0.185371342697663 904 6615653 SGTC_2732 terfenadine 20 µM 0.894848299900988 0.195749265742709 no 662 0.185434093445352 902 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2330 7979373 200 µM 0.892626842788946 0.196340711555954 no 663 0.186028519673909 887 1863007 SGTC_1633 st005664 67.9 µM 0.892606215701013 0.196346208429939 no 664 0.186034044680791 936 2063822 SGTC_39 0986-0283 58.349 µM 0.890885774539092 0.196805013880267 no 665 0.186495226334456 985 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_661 1304-0007 33.6 µM 0.889691078483622 0.197123995782328 no 666 0.186815892884529 892 3117130 SGTC_1917 st066507 28.5 µM 0.888635359278828 0.197406131307445 no 667 0.187099540695539 923 3156428 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.888013262244203 0.197572497825682 no 668 0.187266808727505 932 688667 SGTC_3096 9117468 49.47 µM 0.886048643531207 0.198098449223275 no 669 0.187795657725512 821 41316311 SGTC_651 3253-0966 34.4 µM 0.885144442344118 0.198340798268186 no 670 0.188039366198647 935 781462 SGTC_197 4544-0043 41.561 µM 0.884579201010663 0.198492388246948 no 671 0.188191814269793 957 896523 SGTC_947 3447-0010 211 µM 0.884184397410943 0.198598310608812 no 672 0.188298339760656 915 748350 SGTC_2593 nobiletin 86.24 µM 0.884104650251689 0.198619710213833 no 673 0.188319861570184 862 72344 An anti-infammatory. SGTC_920 mycophenolic acid 780.421 nM 0.882025185893558 0.199178211057253 no 674 0.188881593768998 881 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2725 haloperidol 53.21 µM 0.88195483844815 0.199197121444087 no 675 0.188900614980404 948 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3052 9092717 49.47 µM 0.881677497524418 0.199271685136406 no 676 0.188975616555157 898 25237534 SGTC_1527 coumarin 137 µM 0.877240412505956 0.200466889009976 no 677 0.190178034985899 886 323 A hepatotoxic, DNA x-linker. SGTC_6 0844-0013 19.835 µM 0.876456349650175 0.200678536343728 no 678 0.190390998128116 1126 1584900 SGTC_3025 9087895 49.47 µM 0.876413450381423 0.200690120299654 no 679 0.190402654432473 995 17173641 SGTC_2451 5856223 45.7 µM 0.876068129086658 0.200783380952832 no 680 0.190496498803015 906 2179896 SGTC_2534 helenine 20.12 µM 0.871156194682628 0.202112757611897 no 681 0.191834437254911 905 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2235 salicylic acid 500 µM 0.870665484926531 0.202245853115332 no 682 0.191968414697089 945 338 A COX inhibitor and kinase inhibitor. SGTC_1493 4348-0038 111 µM 0.869994988022638 0.202427797133656 no 683 0.192151571601584 1011 800424 SGTC_1376 2910-0861 41.3 µM 0.869631124378184 0.20252657503008 no 684 0.192251011485855 973 1112859 SGTC_819 1013-0258 27.7 µM 0.869482906003787 0.202566820062121 no 685 0.192291526938745 941 5753198 SGTC_2936 9038235 15.59 µM 0.867778518254855 0.2030299478386 no 686 0.192757796075339 960 4749415 SGTC_1605 st000082 49.1 µM 0.86752026331315 0.203100177738546 no 687 0.192828507063235 962 1114022 SGTC_3118 9124250 49.47 µM 0.867329625998591 0.203152028991162 no 688 0.192880714303902 855 1504786 SGTC_2315 7733312 200 µM 0.866776460521445 0.203302528642367 no 689 0.193032251053301 888 726316 SGTC_1738 st035555 74 µM 0.866348770786028 0.203418935722019 no 690 0.193149464206197 951 5331140 SGTC_3316 9136639 10.545 µM 0.866211325033048 0.203456353662336 no 691 0.19318714197454 952 4903665 SGTC_2387 9077560 195.08 µM 0.865947500501544 0.203528188196991 no 692 0.193259476310084 919 5303272 SGTC_2031 5180455 200 µM 0.865457702414783 0.203661591252306 no 693 0.19339381097766 940 29949 SGTC_3284 9108171 64.8615 µM 0.862092373745829 0.204579592413853 no 694 0.194318343842422 898 8687505 SGTC_2912 7964298 10.93 µM 0.860856164649837 0.204917425398655 no 695 0.194658633533478 965 2975850 SGTC_1209 2323-2347 50.3 µM 0.859991926763742 0.205153802439726 no 696 0.194896746390759 976 5412760 SGTC_3055 9094636 49.47 µM 0.859957768122429 0.205163148470917 no 697 0.194906161339254 934 25236176 SGTC_1716 st033144 30.6155 µM 0.859113890407791 0.205394119342019 no 698 0.195138842273545 990 674617 SGTC_2792 7535235 81.82 µM 0.858267180442185 0.205626020544579 no 699 0.195372473741747 883 1281891 SGTC_2857 9024691 58.44 µM 0.858093148810451 0.205673704455236 no 700 0.195420515084294 944 16478292 SGTC_2025 5147754 141 µM 0.857902864299283 0.205725849094595 no 701 0.195473051237027 964 315777 YLR208W SEC13 SGTC_148 3253-0744 288.01 µM 0.856378383386252 0.206143893549389 no 702 0.195894258769213 974 6893655 SGTC_1030 k029-0042 36.7 µM 0.85503138719785 0.206513686763525 no 703 0.196266885936373 978 6080581 SGTC_337 1315-0038 354 µM 0.854731994364266 0.206595932946647 no 704 0.196349767003082 947 1626437 SGTC_166 k072-0058 166.424 µM 0.854501220410082 0.206659342080502 no 705 0.196413666748128 1022 5846229 SGTC_2241 6772625 37.8075 µM 0.853167654126446 0.207025988138369 no 706 0.196783169013945 972 2285411 SGTC_1082 camptothecin 424.86 nM 0.850082376292073 0.207875717516612 no 707 0.197639644560233 926 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_164 4100-3994 89.624 µM 0.850066523615676 0.207880088880638 no 708 0.197644051085799 1029 4615967 SGTC_2051 5263410 176 µM 0.849415730301818 0.208059591516598 no 709 0.197825001596445 1014 227584 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.848342489160543 0.20835581401556 no 710 0.198123630606775 1059 23665772 A membrane-active detergent. SGTC_2517 totarol 10 µM 0.848197391160113 0.208395881218805 no 711 0.198164024955819 923 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3235 9132602 49.47 µM 0.847761802402586 0.208516191518049 no 712 0.198285319925843 995 4912240 SGTC_1843 st055809 45.5 µM 0.847384921334366 0.208620319700762 no 713 0.198390303177775 920 16413835 SGTC_2797 7859098 81.82 µM 0.846744143635485 0.208797430029258 no 714 0.198568873930057 961 972681 SGTC_367 0335-0881 7.1 µM 0.845998831015956 0.209003545127371 no 715 0.198776698200058 975 23828853 SGTC_1613 st002381 52.1 µM 0.844527580201647 0.209410768940508 no 716 0.199187329080448 1028 551167 SGTC_1522 st012842 45.6 µM 0.842345691881619 0.210015547138646 no 717 0.199797241097687 870 3491067 YOR116C RPO31 SGTC_170 4197-0004 226 µM 0.83932016946205 0.210855860746878 no 718 0.200644833957735 911 218692 SGTC_848 0368-0089 85.6 µM 0.83910976372424 0.210914372421387 no 719 0.200703858795691 994 762535 SGTC_980 1473-0395 201 µM 0.838794688864166 0.211002009303825 no 720 0.200792265809496 919 768876 SGTC_3317 9138495 8.753 µM 0.838632094273162 0.211047242724451 no 721 0.200837897448822 1007 17020139 SGTC_215 1287-0124 461.5 µM 0.837950063425661 0.211237043967633 no 722 0.201029374963012 975 5560863 SGTC_2964 9083345 53.42 µM 0.837679223852391 0.211312443201386 no 723 0.201105442488751 935 17741579 SGTC_1778 st046819 58.9 µM 0.835002540978095 0.212058454391493 no 724 0.201858138855211 1093 671715 SGTC_1815 st051655 58.2 µM 0.83492575731575 0.212079877261386 no 725 0.20187975565519 968 5984156 SGTC_534 k292-0788 63.4 µM 0.834384387549538 0.212230956946321 no 726 0.202032206078482 1066 4146317 SGTC_2294 7971431 200 µM 0.834382136373034 0.212231585311901 no 727 0.202032840156499 900 5741572 SGTC_725 1497-0963 19 µM 0.833346039147855 0.212520904095449 no 728 0.202324799062606 1030 3549977 SGTC_1762 st045503 25.4615 µM 0.830497340766768 0.213317558391658 no 729 0.20312882535781 1022 4645554 SGTC_2096 5468907 200 µM 0.829411721702314 0.213621615387197 no 730 0.203435735454222 1020 759785 SGTC_1471 k673-0312 37 µM 0.82838896684397 0.213908296417882 no 731 0.203725126441192 1017 24099884 SGTC_2755 lomerizine 42.69 µM 0.825371661133327 0.214755359656868 no 732 0.204580309357591 1022 3949 A calcium channel blocker. SGTC_37 0566-0070 1.56 µM 0.82433082448608 0.215048010413615 no 733 0.204875804324197 1048 1626686 SGTC_231 b-estradiol 524 µM 0.82393221268296 0.215160148895214 no 734 0.204989037942537 938 450 A steroid. SGTC_2015 5119600 184 µM 0.822429374556293 0.215583236234913 no 735 0.205416283451637 1013 2828786 SGTC_364 0083-0097 67.7 µM 0.821290822501137 0.215904088691568 no 736 0.205740316997008 992 5207356 SGTC_709 3807-1509 243 µM 0.820740651933939 0.216059229964829 no 737 0.205897004970003 1012 1886677 YPL242C IQG1 SGTC_2565 isoliquiritigenin 100 µM 0.818190343201199 0.216779228286778 no 738 0.206624254193327 871 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_748 act1.228 77.9 µM 0.813989564609144 0.217968203792796 no 739 0.207825464577537 1009 4421505 YNR035C ARC35 SGTC_2464 5717415 7.67 µM 0.812910908848205 0.218274108810074 no 740 0.20813456978175 1004 5285744 SGTC_255 tunicamycin 200.472 nM 0.811827539870111 0.218581599317606 no 741 0.208445298567696 1015 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3318 9139014 38.6185 µM 0.810612976921786 0.218926622689093 no 742 0.208793981103853 991 16643984 SGTC_3145 9085516 49.47 µM 0.8099318965459 0.219120235594271 no 743 0.208989659225883 990 25236195 SGTC_1756 st041558 35.5 µM 0.806132816657204 0.220202016811745 no 744 0.210083135666827 1119 3955792 SGTC_1495 4469-0029 237 µM 0.805472866224893 0.220390248253039 no 745 0.210273429064698 1075 793680 SGTC_1677 st019204 53.9 µM 0.805271185391249 0.220447790170313 no 746 0.210331602908389 951 3945625 SGTC_1710 st031758 61.5 µM 0.803149255009544 0.221053723536484 no 747 0.210944235792264 1019 5394341 SGTC_1623 st003709 20.3 µM 0.801793875760406 0.221441260710393 no 748 0.211336100918842 1028 16192618 SGTC_1182 1222-0449 220 µM 0.800509101676976 0.221808968429583 no 749 0.211707946163798 1004 658318 SGTC_550 4123-0385 25.7 µM 0.795730291167587 0.223179741296403 no 750 0.213094408283091 1031 5731123 SGTC_972 1319-0219 195 µM 0.795640343351685 0.223205588439178 no 751 0.213120555260142 1008 23903702 SGTC_2300 7976697 71.57 µM 0.794567132843578 0.223514114518321 no 752 0.213432671718414 938 2236109 SGTC_1329 1447-1697 50.6 µM 0.793966235522014 0.223686966092982 no 753 0.213607543976293 1017 2840515 SGTC_47 0149-0135 24.25 µM 0.793821155122806 0.223728710692626 no 754 0.213649777568691 1043 5239155 SGTC_517 1365-0151 113 µM 0.793519868063206 0.22381541544589 no 755 0.213737499200125 1008 768657 SGTC_1919 st067113 52.3 µM 0.792832171889734 0.224013393012818 no 756 0.21393780485859 1011 1268243 SGTC_2146 5545642 200 µM 0.790348069445839 0.22472935758187 no 757 0.214662260544576 1090 825326 SGTC_867 0518-0118 155 µM 0.789217135115765 0.225055743310116 no 758 0.214992554350106 1095 6848158 SGTC_1813 st051246 8.6015 µM 0.789050411031723 0.2251038823055 no 759 0.21504127172133 1018 5291959 SGTC_3110 9122132 49.47 µM 0.789039415638736 0.225107057259867 no 760 0.215044484839618 1085 918317 SGTC_2326 6164455 177.58 µM 0.788679878943258 0.225210888591191 no 761 0.215149565467366 1008 2888790 SGTC_524 r073-0010 27.8 µM 0.786970802150075 0.225704827147029 no 762 0.21564947925244 999 2772106 SGTC_321 4534-3890 65.3 µM 0.786285428770922 0.225903078248913 no 763 0.215850143546336 1086 699746 SGTC_3173 9105693 49.47 µM 0.786173610931254 0.225935432017115 no 764 0.215882891947889 1110 17096658 SGTC_2709 st078560 56 µM 0.786061631113615 0.225967835278049 no 765 0.21591569067362 1054 17250903 SGTC_613 3914-0030 117 µM 0.785818929280999 0.226038074190279 no 766 0.215986787597238 851 1145395 SGTC_2419 paclitaxel 166.5 µM 0.783362334879681 0.226749717021263 no 767 0.216707183856154 1062 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_265 mycophenolic acid 32.932 µM 0.783277094658284 0.226774432656481 no 768 0.216732205469457 1131 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_135 0933-0004 26.348 µM 0.779736667998698 0.227802330779814 no 769 0.217772945477073 1004 21230617 YGL099W LSG1 SGTC_1833 st055984 71 µM 0.778209539010847 0.228246512864729 no 770 0.218222747102714 1047 676288 SGTC_643 k048-0106 28.4 µM 0.777084105281021 0.228574168878826 no 771 0.218554575491457 1064 6763920 SGTC_1674 st016616 23.6 µM 0.775637228796562 0.228995796828465 no 772 0.218981606168026 1094 625830 SGTC_1153 4055-0057 267 µM 0.774993983336737 0.229183382205417 no 773 0.21917160742891 1084 882706 SGTC_2697 mebhydrolin 72.4 µM 0.774435616074899 0.229346284965267 no 774 0.2193366142598 1080 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_460 trequinsin 123 µM 0.774404533825268 0.229355355068918 no 775 0.219345801679692 1115 5537 A vasodilator. SGTC_2908 7930301 100 µM 0.771946000876966 0.230073415607687 no 776 0.220073205261768 1082 2223178 SGTC_1174 0739-0097 51.1 µM 0.770915699002946 0.230374708164369 no 777 0.220378450584651 1063 728447 SGTC_1961 st076550 68.7 µM 0.770459592743368 0.230508158341471 no 778 0.220513657667109 1031 1579337 SGTC_1055 3448-0672 86 µM 0.770289832305596 0.230557838852137 no 779 0.220563993193662 1039 748378 SGTC_1249 0481-0015 10.2 µM 0.770153920460749 0.23059761786118 no 780 0.220604297046688 1064 4227577 SGTC_2571 chrysanthemic acid 100 µM 0.770051978481068 0.23062745700444 no 781 0.220634530106307 1027 2743 An insecticide. SGTC_1459 k035-0031 35.7 µM 0.769484713450977 0.230793538916195 no 782 0.220802807947138 958 3877128 YMR208W ERG12 SGTC_1782 st039423 80.636 µM 0.769275383047721 0.230854842823239 no 783 0.220864923879589 1020 2068169 SGTC_1036 k216-0215 33.5 µM 0.768876374334757 0.230971720562736 no 784 0.220983351960496 1068 622330 SGTC_1114 scopoletin 1.73284 µM 0.767249591224639 0.231448580041625 no 785 0.22146656655041 1091 5280460 A coumarin with genotoxic properties. SGTC_558 k064-0027 21.3 µM 0.765099621403576 0.232079642711617 no 786 0.222106112651622 1082 5088526 SGTC_121 0557-0495 61.343 µM 0.76292993496733 0.232717462519973 no 787 0.222752591209484 1240 3104427 SGTC_1260 0700-1617 7.75 µM 0.762804890784028 0.232754251257772 no 788 0.222789881957856 1071 2853078 SGTC_704 1310-0270 142 µM 0.762765013682048 0.232765984016498 no 789 0.22280177487826 1123 5718033 SGTC_3192 9110362 49.47 µM 0.762398634988909 0.232873796417685 no 790 0.222911060345503 1120 16649480 SGTC_2003 4023581 200 µM 0.760800166173278 0.233344494133346 no 791 0.22338821757511 1086 16641307 SGTC_1777 st045864 34.765 µM 0.760180481650884 0.233527113215877 no 792 0.223573355151961 1092 4691462 SGTC_925 2064-1272 59.6 µM 0.759854985775117 0.233623067570986 no 793 0.223670635576108 1021 6815817 SGTC_1993 st073995 70.8 µM 0.759632270744093 0.233688735305001 no 794 0.223737211921626 1096 3098394 SGTC_305 1682-2595 20.8 µM 0.758377088744934 0.234059018163668 no 795 0.224112634867969 1107 226033 SGTC_2752 diclazuril 33.15 µM 0.75604319597948 0.234748387325651 no 796 0.22481164877481 1193 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1513 0337-0559 19 µM 0.756015218765951 0.234756657845183 no 797 0.224820035597627 1048 775073 SGTC_403 arphamenine a 50 µM 0.755711102668274 0.234846569903766 no 798 0.224911212940703 1074 5487158 An arginine aminopeptidase inhibitor. SGTC_1465 k213-0056 144 µM 0.755211275101346 0.234994385484091 no 799 0.225061112255071 1028 24048857 YMR208W ERG12 SGTC_2677 mitomycin C 100 µM 0.755069682328098 0.235036268502272 no 800 0.225103586506293 1099 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1470 k295-0292 231 µM 0.754713543075018 0.235141632409751 no 801 0.225210439351105 1116 5045612 SGTC_3109 9122853 49.47 µM 0.754405614413415 0.235232754223528 no 802 0.225302850675001 1146 1234709 SGTC_1539 benzyladenosine 56 µM 0.754234046318014 0.235283532868405 no 803 0.225354348651137 1107 92208 A nucleotide analog. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.749073932727986 0.236813585525968 no 804 0.226906322725574 1128 804 An inhibitor of viral and cellular DNA polymerases. SGTC_184 1494-0393 24.714 µM 0.74650663145012 0.237576863099398 no 805 0.227680713585006 1134 3090647 SGTC_2493 resveratrol 26.09 µM 0.746412242589351 0.237604951310254 no 806 0.227709213003602 1056 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_11 0438-0307 1.3 µM 0.745363174461444 0.237917255356575 no 807 0.228026099850862 1119 4011476 SGTC_3174 9107204 49.47 µM 0.743108774863388 0.23858914337578 no 808 0.228707913747779 1121 3938802 SGTC_1928 4'-methoxychalcone 40.3 µM 0.743091915923782 0.238594171824264 no 809 0.228713016823608 1160 641818 SGTC_3134 9127454 49.47 µM 0.741930542208187 0.238940709706425 no 810 0.229064709881288 1180 24262820 SGTC_1784 st039334 36.3 µM 0.741157508668542 0.239171524719081 no 811 0.229298971875246 1137 3496984 SGTC_3170 9103054 49.47 µM 0.740250950783908 0.239442363050315 no 812 0.229573868455907 1094 16432970 SGTC_951 1171-0579 82.7 µM 0.73915466713015 0.23977010643032 no 813 0.229906542300228 1154 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_424 splitomicin 100 mM 0.738247088640687 0.240041619873522 no 814 0.230182156485928 1071 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_857 0438-0306 1.35 µM 0.738226240204455 0.240047858912672 no 815 0.230188489927147 1123 4686136 SGTC_405 ebelactone b 50 µM 0.737159797306111 0.240367117245993 no 816 0.2305125892256 1097 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2939 9044578 71.43 µM 0.736843038121889 0.24046198918288 no 817 0.230608903615357 1122 2653634 SGTC_2497 7-hydroxyflavone 100 µM 0.735743862351573 0.240791359320661 no 818 0.230943295395342 1066 5281894 SGTC_42 0133-0086 60.653 µM 0.735401546018719 0.240893985177257 no 819 0.231047490288947 1119 162923 Model of phenazepam hydroxylation. SGTC_2917 7979103 53.79 µM 0.729783199205322 0.242581751185868 no 820 0.232761357809351 1144 2980565 SGTC_1054 3429-0080 167 µM 0.729689450928861 0.242609967625027 no 821 0.232790015366833 1161 1162877 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.728822854273728 0.242870880776206 no 822 0.23305501483886 1106 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2171 5739187 198.077 µM 0.727523359651484 0.243262414338829 no 823 0.233452705357973 1109 2262761 SGTC_141 0443-0274 32.331 µM 0.727001730186775 0.24341967553429 no 824 0.233612447923649 1265 1627241 SGTC_229 benomyl 22.8748 µM 0.72401193042679 0.244322101086794 no 825 0.234529205346844 1154 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_362 0310-0100 9.03 µM 0.723368314255676 0.24451660243222 no 826 0.234726816317408 1153 790235 SGTC_2155 5570423 76 µM 0.723013365651597 0.244623903871855 no 827 0.234835836384882 1104 797402 SGTC_3289 9119912 71.43 µM 0.722803290525331 0.244687421808081 no 828 0.234900372723292 1178 17014829 SGTC_2284 7945075 39.21 µM 0.722575282575702 0.244756371929186 no 829 0.23497042922323 1229 1245402 SGTC_953 1188-0045 9.7 µM 0.722156932602369 0.244882909107431 no 830 0.235098999210696 1153 6144426 SGTC_645 0845-0943 5.41 µM 0.721180461020615 0.245178396747695 no 831 0.23539924584208 1127 1885106 SGTC_76 0433-0009 400.328 µM 0.720080004227869 0.245511632899245 no 832 0.235737869086236 1059 2841569 SGTC_1364 1653-0028 37.6 µM 0.719137402621028 0.245797261303225 no 833 0.236028131916882 1126 5718652 SGTC_1816 st051957 91.6 µM 0.718673721539712 0.245937831998014 no 834 0.236170989162612 1159 674121 SGTC_1142 3253-1408 9.78 µM 0.718408347300831 0.246018302909574 no 835 0.236252770732255 1151 256655 SGTC_1503 4585-0012 61.3 µM 0.716346031111175 0.246644151724912 no 836 0.236888855195937 1152 2922052 SGTC_1979 st071809 45.3 µM 0.715081509468349 0.24702831600605 no 837 0.237279339399052 1182 4976333 SGTC_2484 5809818 12.04 µM 0.71336046366148 0.247551687196925 no 838 0.237811365744584 1152 2870548 SGTC_386 1509-0011 3.07 µM 0.711095408000889 0.248241394009272 no 839 0.238512557683604 1215 3107280 SGTC_3073 9114972 49.47 µM 0.710806386192579 0.248329474469381 no 840 0.238602111345743 1088 41905075 SGTC_1037 k284-1091 78.7 µM 0.710675073010602 0.248369498148668 no 841 0.238642804930047 1165 3334711 SGTC_1352 1496-0991 99 µM 0.71054820953154 0.248408168843545 no 842 0.238682123170874 1170 3000039 SGTC_81 0411-0046 9.971 µM 0.710315336224308 0.248479161946599 no 843 0.238754305796425 1082 12925265 SGTC_19 0279-0214 38.434 µM 0.710068188922385 0.248554518404091 no 844 0.2388309259251 1242 3566274 YBR002C RER2 SGTC_1115 galangin 695.678 nM 0.707318624356027 0.249393695065104 no 845 0.239684247079325 1233 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2977 9011197 71.43 µM 0.706498247094523 0.249644368435257 no 846 0.239939171215061 1134 2704722 SGTC_2529 gangaleoidin 93.61 µM 0.706229535166679 0.249726504777116 no 847 0.240022702931515 1212 4565183 SGTC_83 0170-0301 39.027 µM 0.705721995465785 0.249881682006362 no 848 0.240180519832581 1125 3089716 SGTC_2851 9015922 71.43 µM 0.704796974718584 0.250164633167504 no 849 0.240468295759243 1156 2996893 SGTC_595 3909-8003 73.7 µM 0.704646353724094 0.250210722146866 no 850 0.240515172042759 1207 699517 SGTC_3302 9125395 16.351 µM 0.703563502131663 0.250542199735494 no 851 0.240852323673241 1155 17599668 SGTC_3280 9140961 49.47 µM 0.701572917799682 0.251152154788231 no 852 0.241472772944782 1165 4901226 SGTC_411 enrofloxacin 100 µM 0.700902661461921 0.251357711419619 no 853 0.241681881698922 1239 71188 A bacterial gyrase inhibitor. SGTC_5 0352-0601 109.883 µM 0.700578298632999 0.251457220106098 no 854 0.241783112754792 1112 762456 SGTC_3242 9133940 49.47 µM 0.697563691212191 0.252383042462249 no 855 0.242725047535452 1232 17248444 SGTC_279 1273-0055 2.93 µM 0.69639223680054 0.252743294414334 no 856 0.243091611721669 1239 2847562 SGTC_1452 4194-0072 190 µM 0.695674997821424 0.252963997166374 no 857 0.243316193328693 1227 1343545 SGTC_1168 k815-0004 80.5 µM 0.695064572922947 0.253151911843471 no 858 0.243507417642948 1191 642433 SGTC_2690 usnic acid 100 µM 0.694175875491498 0.253425621806381 no 859 0.243785959864789 1239 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1435 4092-0789 56.7 µM 0.694110385886443 0.253445798103965 no 860 0.243806492910052 1213 2248285 SGTC_2399 5884133 200 µM 0.693501052463222 0.253633564423015 no 861 0.243997582787832 1220 722445 SGTC_1456 k015-0012 13 µM 0.69346085803301 0.25364595291979 no 862 0.244010190793506 1266 2989616 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.692552166651512 0.253926109352674 no 863 0.244295318723882 1209 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_420 mitomycin C 81.9 mM 0.69170295023453 0.254188075926646 no 864 0.244561946938787 1201 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_767 0929-0023 86 µM 0.69148433224184 0.254255538212508 no 865 0.244630611722943 1280 1204563 SGTC_2555 cholic acid 100 µM 0.691230331795684 0.254333930789235 no 866 0.244710402666493 1189 6708657 Influences liver metabolism. SGTC_86 0417-1630 471.922 µM 0.690882275086131 0.254441372678029 no 867 0.244819762916869 1245 3634867 SGTC_2049 5262831 67.185 µM 0.689621349588094 0.254830807797394 no 868 0.245216168902557 1234 763417 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.688824331965455 0.255077126440502 no 869 0.245466910816926 1229 364106 SGTC_1526 st051518 75 µM 0.688821798113297 0.255077909727164 no 870 0.245467708186977 1156 673993 SGTC_2251 lansoprazole 556 µM 0.688398252477805 0.255208857558767 no 871 0.24560101200187 1095 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_484 loperamide 105 µM 0.687351079672857 0.255532763359654 no 872 0.245930758743287 1164 3955 An opioid-receptor agonist. SGTC_3038 9091290 49.47 µM 0.686432451243632 0.255817085242723 no 873 0.246220223346064 1226 25236843 SGTC_554 4483-2211 187 µM 0.686259194016973 0.255870728061421 no 874 0.246274838070327 1192 747107 SGTC_1219 1469-0211 33.1 µM 0.685357304966568 0.25615006009513 no 875 0.246559239430299 1181 6822282 SGTC_1141 3253-0389 52.6 µM 0.685232130774605 0.256188841464245 no 876 0.246598725713238 1193 5402031 SGTC_3172 9105863 49.47 µM 0.685149749897878 0.256214366312657 no 877 0.246624714664226 1185 2348785 SGTC_232 clozapine 119 µM 0.685030722048588 0.256251248181912 no 878 0.246662267340358 1169 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1117 retinoic acid 1.10837 µM 0.684756272000253 0.256336299590235 no 879 0.246748866592963 1226 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1450 4112-4260 37.6 µM 0.683421332560321 0.256750203837209 no 880 0.247170321963367 1202 1633175 SGTC_17 0960-0276 49.807 µM 0.682810040287241 0.256939853948326 no 881 0.247363442229377 1229 6821114 SGTC_3077 9117319 49.47 µM 0.680591211229493 0.257628845541211 no 882 0.248065094801255 1227 17154678 SGTC_1240 0356-0016 42.1 µM 0.680336184928905 0.257708097824003 no 883 0.248145808856163 1188 4305613 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.679305692645651 0.258028463704035 no 884 0.248472095118224 1253 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1948 st076329 66.6 µM 0.678987700167801 0.258127364880946 no 885 0.248572827677292 1132 24208413 SGTC_2407 paclitaxel 400 µM 0.678658959877041 0.258229629473737 no 886 0.248676987758376 1270 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2545 solidagenone 89.61 µM 0.678411547583633 0.258306608385655 no 887 0.248755394708211 1068 6708572 An anti ulcer agent SGTC_1534 6-azauridine 81.6 µM 0.677057721272093 0.258728043191668 no 888 0.249184666160767 1246 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_217 ketoconazole 989 nM 0.676813860369428 0.258803992859909 no 889 0.249262031465799 1172 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2236 dapsone 200 µM 0.676427638614573 0.258924303944779 no 890 0.249384587131794 1246 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_382 3229-0966 23.2 µM 0.676287395663987 0.258967997875489 no 891 0.249429096869976 1241 5722370 SGTC_1466 k213-0079 57.5 µM 0.675196412016793 0.259308033660978 no 892 0.249775492955593 1192 3657981 SGTC_1924 st058459 75.1 µM 0.671556547789764 0.260444166455937 no 893 0.250933024320729 1201 688683 SGTC_614 0462-0418 107 µM 0.670207571883667 0.260865880630251 no 894 0.251362738827944 1137 5188303 SGTC_97 0535-0701 19.132 µM 0.66991140072871 0.260958516070401 no 895 0.251457135811673 1200 2832013 YGL099W LSG1 SGTC_3194 9111903 49.47 µM 0.669644743757867 0.261041934630126 no 896 0.251542141928037 1254 17087251 SGTC_1217 1183-1422 255 µM 0.669443400768763 0.261104930035668 no 897 0.251606337016287 1260 2849664 SGTC_954 1189-0853 2.85 µM 0.665876615254942 0.262222185797856 no 898 0.252744984344547 1229 2828194 SGTC_1485 3909-9022 254 µM 0.664158215924453 0.262761328117791 no 899 0.25329452668928 1258 714516 SGTC_1278 0874-0585 172 µM 0.663967805439989 0.262821103676857 no 900 0.253355458404296 1245 766306 SGTC_1779 st039427 55 µM 0.663738473963707 0.262893106932715 no 901 0.253428855137043 1286 1124498 SGTC_1307 1187-1599 12.2 µM 0.663297155249953 0.263031696244089 no 902 0.253570129076486 1237 1538471 SGTC_2845 9003024 42.97 µM 0.663268522775473 0.263040689119251 no 903 0.253579296267808 1300 2990173 SGTC_2869 9037858 32.47 µM 0.663065210378422 0.263104549907733 no 904 0.253644395321783 1217 27187042 SGTC_2957 9076800 11.52 µM 0.6625798268545 0.263257041769805 no 905 0.253799846849648 1193 16459615 SGTC_727 3032-0951 202 µM 0.662428609990946 0.263304558456056 no 906 0.253848286588888 1232 3652836 SGTC_3239 9133757 49.47 µM 0.662387181991511 0.263317577088879 no 907 0.25386155818769 1245 17036923 SGTC_1229 0139-0193 12.2 µM 0.661331263479854 0.263649507444926 no 908 0.254199948134616 1286 3090752 SGTC_1360 1598-0022 39.8 µM 0.661173898582512 0.263698993724013 no 909 0.25425039906931 1280 761525 SGTC_2158 5657123 3.6195 µM 0.660380166601225 0.26394866950237 no 910 0.25450494827447 1226 2858827 SGTC_123 0083-0120 66.675 µM 0.660191568068631 0.264008012636523 no 911 0.25456545129817 1202 16001701 SGTC_2249 haloperidol 116.36 µM 0.659685017761369 0.264167433965829 no 912 0.25472799157486 1263 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_360 0957-0399 1.01 µM 0.658421122909846 0.26456542018846 no 913 0.255133783017097 1250 6752301 YPR165W RHO1 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.658217730765006 0.264629494561847 no 914 0.255199116528462 1258 688669 SGTC_560 2332-1943 155 µM 0.657701153361335 0.264792266770767 no 915 0.255365090551108 1254 21177716 SGTC_3108 9121785 49.47 µM 0.656181782535721 0.265271311450898 no 916 0.255853584441043 1232 17140271 SGTC_3307 9126885 69.2785 µM 0.655756686631323 0.265405419295844 no 917 0.255990344561425 1240 24824909 SGTC_2430 5571206 200 µM 0.654683399384665 0.265744169421086 no 918 0.25633580778659 1294 1731771 SGTC_3328 9140624 29.0385 µM 0.654030309739208 0.265950404303769 no 919 0.25654613919297 1264 4904392 SGTC_1064 honokiol 6.76 µM 0.653498060348168 0.266118539787592 no 920 0.2567176197371 1261 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_3034 9090421 49.47 µM 0.652842654348492 0.266325653882009 no 921 0.256928860932992 1211 17173761 SGTC_2490 carminic acid 95.39 µM 0.651658230730987 0.266700149020611 no 922 0.257310836883494 1217 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1357 1503-1303 39.5 µM 0.649952731633297 0.267239866808573 no 923 0.257861377416319 1269 292895 SGTC_2094 5332512 191.667 µM 0.646345539395147 0.268383202296008 no 924 0.259027800879327 1321 755774 SGTC_2234 tolnaftate 200 µM 0.644962411193455 0.268822250090112 no 925 0.259475772515383 1262 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_407 eburnamonine 100 µM 0.644455682046816 0.26898319187743 no 926 0.259639993537519 1184 3195 SGTC_1233 0325-0408 14.2 µM 0.643163241087411 0.269393901772812 no 927 0.260059091226471 1315 12874 SGTC_2502 avocadyne acetate 18.59 µM 0.641896435471426 0.269796770188212 no 928 0.260470214406978 1250 3952079 SGTC_2684 capsaicin 100 µM 0.638590267551736 0.27084961387896 no 929 0.261544757148082 1275 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_34 0469-0683 81.75 µM 0.638045734203392 0.271023216097657 no 930 0.261721954786463 1287 3690923 SGTC_2416 tofa 880 nM 0.637779988720286 0.271107958340813 no 931 0.261808453892231 1218 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_464 bw-b 70c 158 µM 0.635353271156618 0.27188241287096 no 932 0.262599018679023 1315 5353454 SGTC_1763 st044482 94.5 µM 0.633538747750533 0.272462212089894 no 933 0.263190942911736 1303 88505 SGTC_508 roscovitine 141 µM 0.633328825148808 0.272529328791798 no 934 0.263259466715448 1341 160355 A CDKinase inhibitor. SGTC_2888 9058547 12.99 µM 0.632581704098147 0.272768265791118 no 935 0.263503418960815 1224 16476514 SGTC_1789 tunicamycin 25 nM 0.63087263199584 0.273315235137742 no 936 0.2640619039037 1286 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2311 7694451 200 µM 0.629904288935883 0.273625383371119 no 937 0.264378603304959 1291 2163142 SGTC_2769 toremifene 3.73 µM 0.628337217683 0.274127665442452 no 938 0.264891527802502 1318 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.628049994672536 0.274219776335957 no 939 0.264985594757437 1315 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2103 5378138 10 µM 0.628031714620396 0.274225639168895 no 940 0.264991582139274 1323 244142 SGTC_3277 9138724 49.47 µM 0.627996871489177 0.274236814333487 no 941 0.265002994722208 1262 15943418 SGTC_2587 piperic acid 92.2 µM 0.627278617939726 0.274467228380888 no 942 0.265238308423747 1263 5370536 SGTC_2165 5727197 32.143 µM 0.626903572352287 0.274587580077149 no 943 0.265361222731485 1419 1361712 SGTC_3165 9101544 49.47 µM 0.626517728459562 0.274711424098875 no 944 0.265487706148405 1311 5002184 SGTC_2456 5770359 74.46 µM 0.625518059407369 0.275032415181124 no 945 0.265815549699463 1334 3118787 SGTC_1418 3966-3099 2.4 µM 0.624693035964373 0.275297467108412 no 946 0.266086272325977 1321 740335 SGTC_2719 novobiocin 32.65 µM 0.62453609317207 0.275347901710134 no 947 0.266137787229147 1335 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1545 lovastatin 49.4 µM 0.624325069997668 0.275415722565689 no 948 0.266207061436509 1342 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2605 digitonin 300 nM 0.623695871500003 0.275617989795031 no 949 0.266413667458931 1350 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_332 4112-0506 40.9 µM 0.622510154509328 0.275999358350213 no 950 0.266803234384386 1320 2790355 SGTC_3111 9122088 49.47 µM 0.622177449338473 0.276106414650001 no 951 0.266912596253655 1227 16876704 SGTC_1292 0kpi-0043 232 µM 0.621055773546864 0.276467492341079 no 952 0.267281463538382 1294 3333905 SGTC_1066 ketoconazole 628 nM 0.620175168243866 0.276751129391615 no 953 0.26757123402405 1361 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2959 9079155 11 µM 0.61934340314743 0.27701916619369 no 954 0.267845078606433 1310 16189457 SGTC_1210 3013-0140 750 nM 0.617972502277953 0.27746121694488 no 955 0.268296732407227 1353 905973 SGTC_3200 9114385 49.47 µM 0.617958878183328 0.277465611801376 no 956 0.268301222891529 1282 17018030 YLR208W SEC13 SGTC_1186 1319-0216 26 µM 0.61351665347485 0.278900394742633 no 957 0.269767387336296 1373 4565136 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.612727687326221 0.279155597912642 no 958 0.270028206020265 1288 2346 DNA damaging agent; causes G2/M arrest. SGTC_1367 1812-0510 76.9 µM 0.612560488219809 0.279209695595795 no 959 0.2700834953774 1323 1142582 YDR527W RBA50 SGTC_1649 st011737 51.3 µM 0.611725500698312 0.279479934105605 no 960 0.270359693572507 1311 1761035 SGTC_140 0062-0056 502.533 µM 0.610806415241512 0.279777537161585 no 961 0.270663872929031 1272 3758964 SGTC_518 1021-0119 62.6 µM 0.609757468436989 0.280117377525604 no 962 0.271011239738772 1265 1097762 SGTC_3054 9094397 49.47 µM 0.607914642106707 0.280714904934437 no 963 0.271622043925488 1305 2598354 SGTC_2944 9067346 25.62 µM 0.60700502438787 0.281010071101554 no 964 0.27192378888106 1314 6473075 SGTC_843 0310-0051 143 µM 0.606544181773765 0.281159669321297 no 965 0.272076726533105 1342 2065037 SGTC_2092 5303694 80.6725 µM 0.606036068274247 0.281324657134562 no 966 0.272245401307502 1311 1963699 SGTC_740 k014-0057 261 µM 0.605946566206872 0.281353723887993 no 967 0.272275118045394 1378 4012779 SGTC_600 1495-0418 41.6 µM 0.604925440987747 0.281685447788528 no 968 0.272614269072651 1331 5377768 SGTC_3274 9138298 49.47 µM 0.604009482338528 0.281983167503479 no 969 0.272918668945838 1298 17015756 SGTC_2067 5224629 34.075 µM 0.603446360836139 0.282166277575779 no 970 0.273105894333746 1315 2835000 SGTC_2395 5646831 180.19 µM 0.602240508343572 0.282558576720863 no 971 0.273507027470242 1387 6808628 SGTC_1572 epiandrosterone 68.9 µM 0.602173685544482 0.282580323800755 no 972 0.273529264949026 1283 441302 A steroid. SGTC_1092 toremifene 6.32 µM 0.600935524562888 0.282983421383987 no 973 0.273941465470268 1342 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1429 4049-0205 9.46 µM 0.599993076289792 0.28329043119739 no 974 0.27425542490545 1367 22774478 SGTC_773 4358-1457 44.6 µM 0.599674224517771 0.283394335779743 no 975 0.274361684764047 1357 1186886 SGTC_2617 dihydrotanshinone i 20.83 µM 0.598713720375709 0.283707446704854 no 976 0.27468190308894 1354 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_900 1112-0045 141 µM 0.597565038222953 0.28408211843968 no 977 0.275065099117852 1269 56211 YIL048W NEO1 SGTC_1046 2001-0062 216 µM 0.596165057716801 0.284539077244297 no 978 0.275532483058593 1324 739778 SGTC_2148 5546263 113.568 µM 0.594465922790516 0.285094152295193 no 979 0.276100263987796 1338 792097 SGTC_2075 5212009 200 µM 0.5922871453195 0.285806671869129 no 980 0.276829161174276 1341 780898 SGTC_1731 st035964 63 µM 0.591790160021571 0.285969318138659 no 981 0.276995556597112 1383 6739575 SGTC_946 3434-1334 87.4 µM 0.590419582510426 0.286418089038219 no 982 0.277454692569548 1364 4047976 SGTC_539 4859-0462 2.54 µM 0.590385054133319 0.286429399047736 no 983 0.277466264189319 1352 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2373 9071805 200 µM 0.590119644945917 0.286516342744091 no 984 0.277555219603975 1387 10149009 SGTC_1859 st055998 20 µM 0.589826001295084 0.286612550174773 no 985 0.27765365440974 1404 676301 SGTC_1721 st082152 9.2685 µM 0.589496096324064 0.286720656293444 no 986 0.277764265021754 1297 5296051 SGTC_1246 0422-0085 105 µM 0.586865704488227 0.287583296678748 no 987 0.278646952312288 1356 264295 SGTC_999 SEC7.066 22.7 µM 0.58671341884325 0.287633276500307 no 988 0.278698096991915 1393 740511 YDR170C SEC7 SGTC_2843 9000894 45.46 µM 0.58644639583352 0.287720922787592 no 989 0.278787786904406 1241 2242070 SGTC_1460 k062-0059 9.15 µM 0.586109544261584 0.287831507247584 no 990 0.278900951451509 1320 1373085 SGTC_1172 0370-0043 85 µM 0.584817805889354 0.288255755944811 no 991 0.279335115185081 1409 376585 SGTC_701 4424-0219 185 µM 0.580754088253246 0.289592332094533 no 992 0.280703101083432 1401 2911779 SGTC_2276 7947513 42.08 µM 0.580359049157863 0.289722417358186 no 993 0.28083625733113 1222 2105100 SGTC_1854 st056233 32.9 µM 0.580189357831947 0.289778304653098 no 994 0.280893464741795 1354 5393174 SGTC_1870 st057514 26.5 µM 0.579727701954196 0.289930375131983 no 995 0.281049129587778 1360 5393161 SGTC_1385 3091-4834 14.1 µM 0.579096538414686 0.290138342349924 no 996 0.281262017811638 1384 4072814 SGTC_1372 2752-0194 270 µM 0.578812533218924 0.290231944334953 no 997 0.281357836699056 1325 823334 SGTC_1636 st007707 68.9 µM 0.576750377683776 0.290912010185817 no 998 0.282054047670731 1423 403051 SGTC_2582 agaric acid 100 µM 0.575328994416036 0.291381192753716 no 999 0.282534407928421 1275 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2393 9031399 185.94 µM 0.575325378519136 0.291382386770562 no 1000 0.282535630431806 1440 1526623 YDL150W RPC53 SGTC_2465 5809242 33.21 µM 0.57462905526661 0.291612364430477 no 1001 0.28277109867339 1391 2731748 SGTC_1806 st050005 60.3 µM 0.573650382576629 0.291935737822798 no 1002 0.283102205309604 1333 5194765 SGTC_906 1165-0455 526 µM 0.57289621220922 0.292185044944179 no 1003 0.2833574847036 1339 3252859 SGTC_821 1114-0266 29.2 µM 0.5721156365485 0.292443185174709 no 1004 0.283621818215115 1367 3123235 SGTC_1697 st025554 27.742 µM 0.571916546087169 0.292509042339501 no 1005 0.283689256950533 1352 1269519 SGTC_3074 9116018 49.47 µM 0.56939722322451 0.293343004373108 no 1006 0.284543300414919 1420 17027303 SGTC_1876 myriocin 605 nM 0.568712169902901 0.293569965406784 no 1007 0.28477574375732 1472 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_831 k061-1017 217 µM 0.56864187481535 0.293593259062602 no 1008 0.28479960049326 1438 1240153 SGTC_2034 5197015 53.07 µM 0.567901096203745 0.293838782590812 no 1009 0.285051063784998 1471 780676 SGTC_3150 9097574 49.47 µM 0.567435415557281 0.293993176305469 no 1010 0.285209197018465 1406 17217476 SGTC_79 0052-0007 94.094 µM 0.565819811763617 0.294529110927495 no 1011 0.285758138584366 1443 2801472 SGTC_481 bay k-8644 50 µM 0.563461904553935 0.295312093543349 no 1012 0.28656019695671 1335 2303 A calcium channel antagonist. SGTC_1050 3232-1156 69.3 µM 0.561542997324021 0.295950004945971 no 1013 0.287213713606208 1367 700529 SGTC_3250 9135583 49.47 µM 0.561532164059816 0.295953608094574 no 1014 0.287217405061097 1449 7699353 SGTC_1775 st081588 35.1725 µM 0.561326749378954 0.296021932922272 no 1015 0.287287404744385 1399 1426443 YGL099W LSG1 SGTC_1280 0880-0253 10.1 µM 0.560909212831905 0.296160835826616 no 1016 0.287429714611904 1383 6836607 SGTC_1940 st075990 51.1 µM 0.560601525712295 0.296263213986605 no 1017 0.287534605599056 1476 1084979 SGTC_1231 0242-0792 125 µM 0.560118912180545 0.296423828908829 no 1018 0.28769916570098 1374 3707635 SGTC_402 epigallocatechin gallate 10 µM 0.558710824155537 0.296892671870807 no 1019 0.288179545464552 1388 65064 An antioxidant. SGTC_1794 st048918 76.9 µM 0.555275174542502 0.298038041916908 no 1020 0.289353228326829 1364 672303 SGTC_2514 salinomycin 42.74 µM 0.555097166138702 0.298097440835993 no 1021 0.289414100514721 1487 23682228 A polyether potassium ionophore. SGTC_499 genistein 192 µM 0.555053258022937 0.298112093190444 no 1022 0.289429116365978 1442 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1191 1487-1166 10.6 µM 0.554710655615983 0.298226432567349 no 1023 0.289546293303836 1499 3955771 SGTC_2431 5490079 200 µM 0.553819017439419 0.298524099520404 no 1024 0.289851355936333 1400 5722345 SGTC_2288 7946289 167.31 µM 0.553669822535915 0.298573920356206 no 1025 0.289902415790371 1508 1246052 SGTC_3201 9113999 49.47 µM 0.553599377721803 0.298597445393037 no 1026 0.289926526001672 1482 16649224 SGTC_3004 9076122 71.4286 µM 0.552969146185804 0.298807948631092 no 1027 0.290142268808128 1452 44782551 SGTC_479 n-linoleoylglycine 10 µM 0.552927330040789 0.298821918000759 no 1028 0.29015658610101 1403 6433346 An anti-infammatory. SGTC_177 1327-0068 8.361 µM 0.552731802153834 0.298887241238767 no 1029 0.290223536646152 1389 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_865 0488-0499 301 µM 0.552133710815447 0.299087095773521 no 1030 0.290428373527833 1408 9634651 SGTC_2649 anisomycin 9.56 µM 0.551834151495998 0.29918721747624 no 1031 0.290530993317267 1376 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1004 4084-0029 199 µM 0.551115671511518 0.299427416987748 no 1032 0.290777191543853 1436 716894 YLR208W SEC13 SGTC_1063 disulfiram 1.84 µM 0.549992538907037 0.299803073498421 no 1033 0.29116224552958 1391 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_350 k064-0020 19.8 µM 0.549831251331352 0.299857037209526 no 1034 0.29121756079268 1474 2790705 SGTC_1344 1488-0097 29.1 µM 0.549744365427702 0.299886109378933 no 1035 0.291247361256419 1431 747966 SGTC_808 0711-0032 135 µM 0.548645929400579 0.300253757890169 no 1036 0.291624229797887 1423 4252555 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.547695944811976 0.300571883643832 no 1037 0.291950348526835 1373 6312947 SGTC_2895 9054447 58.44 µM 0.545996671872532 0.301141306309518 no 1038 0.292534112470971 1425 2697450 SGTC_128 0906-2981 13.371 µM 0.545504986122871 0.301306159757783 no 1039 0.292703126085034 1459 6740226 SGTC_513 4245-1575 41.7 µM 0.545179713920543 0.301415240045707 no 1040 0.292814961099682 1434 719745 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.543483388301961 0.301984392003729 no 1041 0.29339851262614 1518 5282309 SGTC_1363 1636-0063 10.4 µM 0.543110083103822 0.302109708314357 no 1042 0.293527005327227 1430 6072185 SGTC_3211 9128781 49.47 µM 0.542943295659221 0.302165705401758 no 1043 0.293584422457075 1417 17194361 SGTC_1398 3558-0053 112 µM 0.541332974287993 0.30270659291021 no 1044 0.294139048205612 1393 4532369 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.541221833878227 0.30274393962779 no 1045 0.294177344962159 1521 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1202 1988-0068 29.6 µM 0.540271953094106 0.303063213984047 no 1046 0.29450474877972 1364 2850480 SGTC_1824 st053723 68.6 µM 0.539062118572534 0.303470082067409 no 1047 0.294921996475027 1382 675225 SGTC_1453 4237-0541 195 µM 0.538556210595326 0.303640291545274 no 1048 0.295096554741435 1429 739892 SGTC_2906 7926292 26.41 µM 0.536394312682837 0.304368127830155 no 1049 0.295843030600735 1406 2966319 SGTC_1564 D-Arginine 115 µM 0.536223157297608 0.304425783097473 no 1050 0.295902165411507 1350 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1908 st060353 56.5 µM 0.536167615177944 0.304444494016506 no 1051 0.295921356583214 1564 4227716 SGTC_2723 salbutamol 83.58 µM 0.535870571016159 0.304544570351453 no 1052 0.29602400236513 1454 9884233 β2-adrenoceptor agonist SGTC_873 0591-4978 488 µM 0.535778759019018 0.304575505440658 no 1053 0.296055731978091 1578 3305145 SGTC_1017 4239-0030 168 µM 0.534585015138287 0.304977852089538 no 1054 0.296468423900488 1384 1149593 SGTC_334 1502-1024 68.5 µM 0.533256873632087 0.305425774150976 no 1055 0.296927888320603 1433 3296216 SGTC_289 k017-0060 526 µM 0.532157063823716 0.305796910898974 no 1056 0.297308608860836 1432 5512909 SGTC_2622 2-methoxyxanthone 59.94 µM 0.531118089728379 0.306147701621993 no 1057 0.297668474679665 1551 71034 A hepatoprotective. SGTC_2742 clothiapine 36.27 µM 0.530747357295345 0.306272915753853 no 1058 0.297796932073245 1478 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1619 st003326 88.7 µM 0.527983607747228 0.307207078990957 no 1059 0.29875535667759 1500 2849032 SGTC_1327 1436-0082 2.18 µM 0.527351919659936 0.307420769265415 no 1060 0.298974612801037 1411 15992205 SGTC_1548 st061468 90.8 µM 0.52729789957503 0.307439046457368 no 1061 0.298993366323635 1445 390799 SGTC_2787 5284540 71.43 µM 0.525703674704388 0.307978652691198 no 1062 0.299547055111086 1469 736958 SGTC_2735 sertaconazole 140 nM 0.52565560206997 0.307994930563427 no 1063 0.299563758389457 1509 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1490 4089-0339 670 nM 0.524150363656401 0.308504810231369 no 1064 0.300086980681661 1441 742542 SGTC_2078 5212016 200 µM 0.523489811480703 0.308728680295586 no 1065 0.300316719668947 1440 1899708 SGTC_713 1488-1073 324 µM 0.522673745491438 0.309005354269707 no 1066 0.300600655820394 1443 3312542 SGTC_3144 9087057 49.47 µM 0.522022603298574 0.309226191253854 no 1067 0.300827296462094 1462 17249618 SGTC_456 gingerol 170 µM 0.517671322561441 0.310703708803047 no 1068 0.302343805006993 1505 442793 A herb. SGTC_2662 daunorubicin 22.37 µM 0.517226261847528 0.310855006065785 no 1069 0.302499110724148 1412 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2354 9060492 162 µM 0.516749757413215 0.311017027994803 no 1070 0.302665428486215 1558 6471895 SGTC_1439 4092-1168 46 µM 0.514674473167101 0.311723096942062 no 1071 0.303390257114044 1474 2886240 SGTC_1849 st056239 19.2 µM 0.5128392390373 0.312348071520583 no 1072 0.304031889577819 1365 5393181 SGTC_3081 9117243 49.47 µM 0.512793236683049 0.312363744209064 no 1073 0.304047980637113 1554 45595589 SGTC_2688 kanamycin b 96.69 µM 0.512731202361408 0.312384879417077 no 1074 0.304069680083032 1469 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_419 nsc-638432 893 µM 0.512490985998326 0.312466727398204 no 1075 0.304153713658602 1469 368090 SGTC_2137 5261020 140 µM 0.512196425407237 0.312567104503757 no 1076 0.304256772299147 1443 763655 SGTC_446 go6976 132 µM 0.511981266219163 0.312640432864734 no 1077 0.30433206040279 1500 3501 A protein kinase C inhibitor. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.509839598408376 0.313370738214929 no 1078 0.305081920570399 1455 4620898 SGTC_3348 9149464 3.537 µM 0.509673888587394 0.3134272755645 no 1079 0.305139974574905 1444 1951442 SGTC_760 0568-0725 82.9 µM 0.509197454320017 0.313589851186821 no 1080 0.305306913641117 1557 3916171 SGTC_1147 3809-1045 12.3 µM 0.509078036178572 0.313630606407132 no 1081 0.305348763229961 1425 325925 SGTC_2281 7943571 200 µM 0.508466362654842 0.313839395014686 no 1082 0.305563161543242 1532 1244024 SGTC_1084 voriconazole 435 nM 0.508046785778162 0.313982647845112 no 1083 0.30571026643118 1485 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1404 3909-7820 48.3 µM 0.507625670397168 0.314126454147591 no 1084 0.305857942256847 1519 23741373 SGTC_1978 st071761 42 µM 0.506802767058932 0.314407548101422 no 1085 0.306146607317776 1418 5147680 SGTC_2544 sphondin 68.51 µM 0.504111585646058 0.315327574496056 no 1086 0.307091482963194 1527 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_864 0469-0573 172 µM 0.503723558850255 0.315460322781268 no 1087 0.307227825367565 1444 689425 SGTC_2438 5259590 200 µM 0.502403812607141 0.31591200087056 no 1088 0.307691748851667 1554 1201127 SGTC_789 1309-1135 70.6 µM 0.50081936308337 0.316454635874249 no 1089 0.308249128508781 1442 3092424 SGTC_2020 4017018 200 µM 0.500691194055216 0.316498547914866 no 1090 0.308294235329341 1473 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1449 4112-4002 201 µM 0.497995061874968 0.317422869577242 no 1091 0.309243761373129 1404 2059539 SGTC_782 0083-0095 30.5 µM 0.497375832153888 0.317635322775822 no 1092 0.309462022543069 1486 3591729 An indicator and reagent. SGTC_125 0133-0007 11.75 µM 0.497057893006766 0.317744428720432 no 1093 0.309574113332476 1571 26541 SGTC_82 0054-0107 293.755 µM 0.49621917444687 0.318032324448033 no 1094 0.309869892089164 1567 3104697 SGTC_1922 5578187 25 µM 0.495947122946544 0.318125731570566 no 1095 0.309965859014761 1583 1350412 SGTC_1043 0916-0009 19.3 µM 0.495182396748505 0.31838835731194 no 1096 0.310235687654941 1659 3101130 SGTC_3241 9133421 49.47 µM 0.495098023135006 0.318417338875548 no 1097 0.310265464594965 1511 17018221 SGTC_258 haloperidol 50.781 µM 0.494610780505972 0.318584723990263 no 1098 0.310437445461648 1426 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_452 diindolylmethane 8 µM 0.493013973032491 0.319133543343353 no 1099 0.31100135714 1507 3071 Inhibits expression of several cancer promoting factors. SGTC_38 0929-0051 58.268 µM 0.492683137191461 0.319247300566181 no 1100 0.311118247209712 1588 1379719 SGTC_2916 7875993 68.79 µM 0.489677358854329 0.320281609916824 no 1101 0.312181112868029 1611 1299250 SGTC_1047 2043-3044 82 µM 0.48807134387029 0.320834824433906 no 1102 0.312749653932614 1434 669592 SGTC_1325 1431-0015 227 µM 0.487038253838573 0.321190897348825 no 1103 0.313115611069005 1416 1103340 SGTC_3310 9130229 44.1445 µM 0.486098354632426 0.321514993265891 no 1104 0.313448716724482 1556 7761258 SGTC_2008 4012253 172 µM 0.485368414403348 0.321766784934711 no 1105 0.313707516745083 1485 603940 SGTC_2766 oltipraz 83.91 µM 0.483813227426236 0.322303517038509 no 1106 0.314259213378316 1577 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3115 9123671 49.47 µM 0.483785870215305 0.322312961985131 no 1107 0.31426892196397 1576 3286988 SGTC_908 3448-7491 47.7 µM 0.483634632489846 0.322365178158555 no 1108 0.314322595850671 1493 1203031 SGTC_335 4077-0256 27.6 µM 0.482461781123587 0.322770234471697 no 1109 0.314738971046131 1547 3121989 SGTC_2873 9040596 71.43 µM 0.481370904098189 0.323147168951212 no 1110 0.315126455996485 1490 6463863 SGTC_2287 7945887 168.79 µM 0.481308192722453 0.323168843353259 no 1111 0.315148737579169 1541 1245853 SGTC_2323 6148992 148.28 µM 0.479078192056508 0.323939969376225 no 1112 0.315941501695022 1468 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_193 1273-0060 1.558 µM 0.478714397064781 0.324065840174937 no 1113 0.316070911109142 1453 2847393 YHR072W ERG7 SGTC_2368 9071271 200 µM 0.477475507003402 0.324494639233546 no 1114 0.316511778959654 1474 27209959 SGTC_2206 7254556 146.969 µM 0.476856554699933 0.324708955461734 no 1115 0.316732135298824 1559 4398905 SGTC_87 0100-0052 35.5 µM 0.473570423608776 0.32584777030903 no 1116 0.31790313531799 1581 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2261 9010538 184.68 µM 0.47259767646112 0.326185190178219 no 1117 0.318250120250418 1455 6457250 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.472498666328472 0.326219542120618 no 1118 0.318285446728647 1615 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.471747692377965 0.326480143377683 no 1119 0.318553445464905 1526 17037758 SGTC_2747 doxorubicin 7.63 µM 0.471232346920102 0.326659026397466 no 1120 0.318737410829984 1495 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1990 st072050 59.8 µM 0.470843929918997 0.326793877265954 no 1121 0.318876095459863 1481 17233948 SGTC_2385 9074692 200 µM 0.469562221847526 0.327239021959739 no 1122 0.319333910310158 1480 17046906 SGTC_815 1582-0027 36.9 µM 0.469400914059872 0.327295062524571 no 1123 0.319391547571633 1575 3128206 SGTC_3171 9103192 49.47 µM 0.469041919124797 0.327419796320107 no 1124 0.3195198365514 1576 13018434 SGTC_553 k007-0256 45.7 µM 0.469018580196919 0.327427906163193 no 1125 0.319528177604422 1552 6287000 SGTC_1722 st034304 3.6505 µM 0.468036123217862 0.327769365510147 no 1126 0.319879378724598 1497 4036148 YLR033W RSC58 SGTC_33 0986-0033 35.816 µM 0.466904836622522 0.328162730008739 no 1127 0.320283982373926 1515 2848082 SGTC_2434 5670830 169.91 µM 0.466870650704433 0.328174619910028 no 1128 0.320296212266815 1531 1549830 SGTC_3156 9099931 49.47 µM 0.466649338556676 0.328251596738361 no 1129 0.320375390636951 1581 18111053 SGTC_168 3970-0862 530.542 µM 0.466340241379821 0.328359119175814 no 1130 0.320485989353524 1545 3135186 SGTC_2820 7989630 71.43 µM 0.465697340814636 0.328582803879048 no 1131 0.320716078025914 1532 2984098 SGTC_1691 st019933 84.6 µM 0.464599487152144 0.328964922643706 no 1132 0.321109149805596 1581 6176082 SGTC_2913 7966556 36.57 µM 0.463851808000156 0.329225262114037 no 1133 0.321376961116124 1613 2976516 SGTC_2404 5161160 200 µM 0.463628046612191 0.329303191217739 no 1134 0.321457128308364 1579 2831543 SGTC_1190 1486-1332 13 µM 0.463525704591086 0.329338836219573 no 1135 0.321493797247761 1495 4150046 SGTC_3187 9109394 49.47 µM 0.463414818544124 0.329377458795919 no 1136 0.321533529457802 1467 17098090 SGTC_1687 st020778 55.3625 µM 0.461179673322433 0.330156367075628 no 1137 0.32233485189742 1556 4259299 SGTC_541 4513-1321 94 µM 0.460183552841558 0.330503734840332 no 1138 0.322692237698982 1489 747515 SGTC_2791 5663188 71.43 µM 0.459919758118572 0.330595749979281 no 1139 0.322786908813988 1613 54690634 SGTC_1473 k844-0725 134 µM 0.458413565236358 0.33112132627555 no 1140 0.323327673842594 1581 54682906 SGTC_1734 st037168 69.4 µM 0.45796617272758 0.331277505183671 no 1141 0.323488372157576 1532 708907 SGTC_2461 5755302 26.15 µM 0.457886863136971 0.33130519419414 no 1142 0.323516862699813 1640 2788904 SGTC_2202 7226349 200 µM 0.457420228624429 0.331468126932744 no 1143 0.323684513693234 1510 844334 SGTC_676 falcarinol 140 µM 0.457111249368084 0.331576029428818 no 1144 0.323795542493409 1662 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_295 k015-0027 31 µM 0.456681813763868 0.331726021200398 no 1145 0.323949882196708 1538 3887424 SGTC_2951 9072950 58.06 µM 0.455743494574293 0.332053847913803 no 1146 0.324287220611051 1540 16488155 SGTC_2692 st077426 47.7 µM 0.455719431287256 0.332062256753983 no 1147 0.324295873586144 1616 25238571 SGTC_825 1988-2224 89.6 µM 0.454568643748714 0.332464494516397 no 1148 0.32470979874373 1545 1180859 SGTC_1755 st041960 45.185 µM 0.454539395554606 0.332474720230716 no 1149 0.32472032180984 1552 2257073 SGTC_2466 5983409 37.09 µM 0.453621699555505 0.332795627165303 no 1150 0.325050566229923 1532 2879657 SGTC_77 0828-0286 12.516 µM 0.451968443519017 0.33337405943078 no 1151 0.325645858006225 1482 745345 SGTC_632 0781-2353 4.65 µM 0.451220250273085 0.333635963625965 no 1152 0.325915408036965 1581 6811515 YHR007C ERG11 SGTC_2983 9022671 12.99 µM 0.449091451358683 0.334381590520583 no 1153 0.326682843494055 1692 6405161 SGTC_803 4488-1585 147 µM 0.448218532909197 0.334687525592471 no 1154 0.326997744375687 1620 747204 SGTC_1694 st024011 44.9 µM 0.447650713644634 0.334886590327401 no 1155 0.327202648444906 1582 2787533 SGTC_2378 9074213 121.43 µM 0.44574741025928 0.335554184104188 no 1156 0.327889856848519 1526 657714 SGTC_2027 5150920 200 µM 0.443888687004267 0.336206642600411 no 1157 0.328561532063134 1617 786715 SGTC_2703 st077852 53.4 µM 0.443716921743468 0.336266961465529 no 1158 0.328623629814793 1578 6281836 SGTC_3063 1327-0034 4 µM 0.441910914933531 0.336901432396006 no 1159 0.329276835966664 1542 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2000 st075254 36.4 µM 0.441890109551575 0.336908744274587 no 1160 0.329284364009831 1543 17234175 SGTC_2476 5806916 10.51 µM 0.437505981256401 0.338450880820434 no 1161 0.330872219644974 1605 2870194 SGTC_1863 st057641 20.1 µM 0.437493924038596 0.338455125752998 no 1162 0.330876590776173 1587 3921635 SGTC_2243 6634756 200 µM 0.435678111212565 0.339094645191196 no 1163 0.331535144540616 1672 885676 SGTC_2973 9094665 17.96 µM 0.434765004646693 0.339416411792414 no 1164 0.331866504452173 1693 25237061 YIL048W NEO1 SGTC_475 α-linolenic acid 10 µM 0.4308924166291 0.340782359433317 no 1165 0.333273298843167 1649 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_654 1124-0271 80.9 µM 0.430331962052258 0.340980217750875 no 1166 0.333477090101424 1535 5403748 SGTC_2701 st077767 14.721 µM 0.430310590437731 0.340987763477693 no 1167 0.333484862174111 1564 5721188 SGTC_1748 st037455 53.6035 µM 0.43007856538821 0.341069689207529 no 1168 0.333569245777952 1631 580690 SGTC_2316 5844804 197.44 µM 0.429763026889044 0.341181114727372 no 1169 0.333684015329508 1704 776813 SGTC_3223 9129970 49.47 µM 0.429552751689918 0.341255376505895 no 1170 0.33376050652627 1608 17248386 SGTC_2522 biochanin a 4.94 µM 0.429546397538036 0.34125762066378 no 1171 0.333762818065157 1628 5280373 A possible chelator. SGTC_754 3474-0146 171 µM 0.429046988877716 0.341434019253576 no 1172 0.333944514681328 1482 24762078 SGTC_1736 st036774 51 µM 0.427654698614875 0.341925979775504 no 1173 0.334451268093873 1771 1272247 SGTC_2472 5377652 49.4 µM 0.426892797114233 0.342195308535831 no 1174 0.33472870604324 1556 1610903 SGTC_2894 9048625 32.47 µM 0.426824512795105 0.342219450658666 no 1175 0.334753575426602 1715 4092861 SGTC_854 0422-0053 192 µM 0.426159087869308 0.342454747357259 no 1176 0.334995963402013 1557 3596728 SGTC_2048 5246248 200 µM 0.426110786937351 0.34247182912607 no 1177 0.335013560197836 1654 677046 SGTC_503 tyrphostin 8 294 µM 0.425139728919946 0.342815315007334 no 1178 0.335367408827262 1662 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1977 st070720 65.3 µM 0.424530885257313 0.343030743532588 no 1179 0.335589342919995 1567 682188 SGTC_1106 tegaserod maleate 11.7 µM 0.42378855168065 0.34329347413658 no 1180 0.335860014017366 1633 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1454 4239-0054 42.6 µM 0.422520917982857 0.343742296798084 no 1181 0.33632241787429 1669 1340767 SGTC_753 1322-0200 289 µM 0.42196504181104 0.34393918172208 no 1182 0.336525266993196 1602 5403907 SGTC_2220 6782180 200 µM 0.419654017151596 0.344758173207838 no 1183 0.337369110647987 1623 833803 SGTC_2153 5569715 200 µM 0.419300207559335 0.344883622226069 no 1184 0.337498372451464 1624 2054701 SGTC_2185 6113692 200 µM 0.418733975042112 0.34508442477339 no 1185 0.337705281350691 1608 874150 SGTC_1467 k284-1082 293 µM 0.418423136067442 0.345194675883072 no 1186 0.337818886913292 1696 3334705 SGTC_2175 5807670 165.306 µM 0.416920144176727 0.34572795553188 no 1187 0.338368409338903 1621 241186 SGTC_992 3909-8734 162 µM 0.416718792988229 0.345799420646247 no 1188 0.338442053349761 1582 4288319 SGTC_2057 5236571 38.335 µM 0.416643359446619 0.345826195514655 no 1189 0.338469644689116 1699 54684039 YBR257W POP4 SGTC_1629 st005085 44.9 µM 0.416071100772759 0.346029341807677 no 1190 0.338678988075373 1531 24207091 SGTC_723 4182-0001 115 µM 0.41286901907467 0.347166866239516 no 1191 0.339851290297512 1581 744821 YLR208W SEC13 SGTC_104 0074-0074 590.992 µM 0.411892009109203 0.347514219339042 no 1192 0.340209289028492 1636 3943124 SGTC_1128 3448-9350 235 µM 0.411550794043203 0.347635560586277 no 1193 0.340334351974307 1592 619386 SGTC_1632 st005650 90 µM 0.411494238828603 0.347655673985984 no 1194 0.34035508242125 1606 2759605 SGTC_1645 Cervolide 78 µM 0.407282661290529 0.349154688646239 no 1195 0.341900197959698 1604 23173 A fragrance. SGTC_836 0330-0104 1.35 µM 0.40638254532477 0.349475370772311 no 1196 0.342230771339386 1646 46494820 SGTC_921 1561-0023 372 µM 0.404675428051305 0.350083856309061 no 1197 0.342858053155884 1574 24050882 SGTC_3324 9138759 60.749 µM 0.40425202117201 0.350234835284508 no 1198 0.343013701555454 1633 45595710 SGTC_2338 7999974 200 µM 0.403476487320603 0.350511437526266 no 1199 0.343298864260033 1786 315925 SGTC_327 1273-0057 3.96 µM 0.401378768853954 0.35126000760757 no 1200 0.344070639142026 1629 3108138 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.40019899884875 0.351681261995378 no 1201 0.344504975972872 1695 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_282 k297-0036 65.7 µM 0.398138914724472 0.352417282161788 no 1202 0.345263895303574 1670 5061378 SGTC_840 0245-0196 390 µM 0.39657360342414 0.352976901396059 no 1203 0.34584096057355 1698 3827528 SGTC_1019 4262-0212 3.4 µM 0.395961424310066 0.353195850045456 no 1204 0.346066743129005 1704 4677213 SGTC_1832 st054113 55 µM 0.394856874566519 0.353591020216686 no 1205 0.346474259165467 1694 1251267 SGTC_800 3448-7362 155 µM 0.394484737779685 0.353724193617363 no 1206 0.346611596532594 1684 15991913 SGTC_3069 9117009 49.47 µM 0.393945703299856 0.353917125007774 no 1207 0.346810563372137 1632 41904981 SGTC_3339 9145883 14.936 µM 0.393014563861458 0.354250487083764 no 1208 0.347154362366293 1704 2030670 SGTC_2136 5328288 199.296 µM 0.392291624201961 0.354509387529501 no 1209 0.347421375803143 1610 262395 SGTC_1684 st024538 14.6195 µM 0.388975272616681 0.355697905334338 no 1210 0.348647219196574 1618 6732859 SGTC_1075 aripiprazole 15.2 µM 0.386959620189986 0.356420964020971 no 1211 0.34939305103728 1635 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1298 1079-1278 263 µM 0.383174511392736 0.357780159209818 no 1212 0.350795187708034 1657 2840950 SGTC_73 0327-0325 16.231 µM 0.382245911921733 0.35811388654405 no 1213 0.351139484960065 1806 53298 SGTC_2450 5739737 12.93 µM 0.381463897426922 0.358395017153235 no 1214 0.351429527655231 1652 2262825 SGTC_2239 6685329 187.64 µM 0.380943394873918 0.358582177987827 no 1215 0.351622625714729 1638 805680 SGTC_15 0266-0086 27.098 µM 0.379920787150332 0.35894998327148 no 1216 0.352002108174746 1728 1712902 YIL048W NEO1 SGTC_1868 st057644 42.7 µM 0.379400773574418 0.359137068762992 no 1217 0.352195138098422 1621 688665 SGTC_3100 9120536 49.47 µM 0.378613771439605 0.359420273080529 no 1218 0.352487347054513 1742 16421196 SGTC_1699 st031318 29.054 µM 0.378337891402098 0.35951956736464 no 1219 0.352589800203508 1716 5340658 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.377982954869012 0.359647329482947 no 1220 0.352721628171914 1601 5355888 SGTC_3287 9117173 37.0625 µM 0.37741328824825 0.3598524181283 no 1221 0.352933246610181 1664 2789709 SGTC_683 panaxydol 45 µM 0.376446395690869 0.360200606505721 no 1222 0.353292529747344 1750 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_3288 9119690 36.221 µM 0.376390474559247 0.360220747855957 no 1223 0.353313313226125 1599 17595618 YKL019W RAM2 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.375961532670504 0.360375254566133 no 1224 0.35347274701506 1775 756377 SGTC_1368 1852-0141 284 µM 0.372242308281079 0.361715888785949 no 1225 0.354856224154961 1676 2838987 SGTC_2831 7999036 19.48 µM 0.371779309295813 0.361882900978819 no 1226 0.355028585014671 1835 2988270 SGTC_832 4083-0019 164 µM 0.371474410885318 0.361992897774227 no 1227 0.355142105901244 1798 1990758 SGTC_286 k060-0067 22.9 µM 0.371159419425606 0.362106547765083 no 1228 0.355259398172398 1661 5985051 SGTC_2975 9084847 53.72 µM 0.370045423097511 0.362508578905675 no 1229 0.355674323043024 1655 27211724 SGTC_1097 itavastatin 7.23 µM 0.368141446825907 0.363196057530906 no 1230 0.356383883786444 1699 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1936 st074407 74.3 µM 0.366869996028275 0.363655392601922 no 1231 0.356857996491917 1631 809813 SGTC_564 3555-0129 330 µM 0.365585434077968 0.364119663423392 no 1232 0.357337222865574 1713 563260 SGTC_319 1348-1596 45.5 µM 0.365178234202692 0.364266876684489 no 1233 0.35748918231078 1793 5380505 SGTC_1022 4477-0945 21.3 µM 0.364037074526888 0.36467954199527 no 1234 0.357915162283489 1649 4648966 SGTC_3008 9078912 71.4286 µM 0.362252401442421 0.365325228448569 no 1235 0.358581712068292 1661 16648731 SGTC_1337 1486-1011 40.3 µM 0.362081991534356 0.365386901967035 no 1236 0.358645380297732 1659 X1337 SGTC_1237 0330-0133 46.1 µM 0.359785903806122 0.366218224229247 no 1237 0.359503622703959 1686 X1237 YHR072W ERG7 SGTC_2327 6189656 200 µM 0.358560121088146 0.366662289019674 no 1238 0.359962092153525 1811 5349088 SGTC_1546 5-methoxyflavanone 78.7 µM 0.358472725230619 0.36669395677674 no 1239 0.359994787813235 1799 147795 SGTC_2452 5863136 48.41 µM 0.358437086680218 0.366706870612158 no 1240 0.360008120843504 1641 2184096 SGTC_4 0960-0234 25.671 µM 0.356488224645909 0.367413281419578 no 1241 0.360737484508879 1673 6821112 SGTC_2643 anethole 100 µM 0.35640792549356 0.367442397378749 no 1242 0.360767547440833 1703 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1406 3909-7906 11.9 µM 0.355307510538883 0.36784147751858 no 1243 0.361179614740275 1729 X1406 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.353580960909571 0.368467921218943 no 1244 0.361826472394979 1760 5377381 SGTC_897 1000-0139 31.4 µM 0.352380115291249 0.368903830173115 no 1245 0.362276606276766 1809 6151020 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.352108569555917 0.369002425131714 no 1246 0.362378420926947 1721 688801 SGTC_3183 9108214 49.47 µM 0.351952879254502 0.369058958277806 no 1247 0.362436800580855 1739 4974831 SGTC_1388 3346-4487 254 µM 0.350810215746258 0.369473960671893 no 1248 0.362865366322972 1747 3345614 SGTC_1848 st056003 16.4 µM 0.350560980356888 0.369564500357692 no 1249 0.362958867035691 1781 146492 SGTC_109 0132-0036 33.701 µM 0.344515632907913 0.3717627969123 no 1250 0.365229270719979 1766 67274 A color developer. SGTC_759 3486-0358 89.3 µM 0.341710943415816 0.372784105282903 no 1251 0.366284217846052 1879 875103 SGTC_894 0960-0238 55.9 µM 0.340831691969048 0.373104463236502 no 1252 0.366615145339716 1766 6741907 YDL195W SEC31 SGTC_158 k038-0087 26.446 µM 0.340626257610398 0.37317932652859 no 1253 0.366692479819555 1737 X158 SGTC_1383 3049-0032 20.7 µM 0.338908329872026 0.373805551770411 no 1254 0.367339394548471 1835 712864 SGTC_336 4111-0029 111 µM 0.338312424298845 0.374022851365947 no 1255 0.367563880960578 1684 3131175 SGTC_2669 eugenol 100 µM 0.337924856633977 0.374164201117396 no 1256 0.367709907707978 1824 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_392 N-ethylmaleimide 8.33 µM 0.337762066544001 0.374223577316226 no 1257 0.367771249044235 1691 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_264 promethazine 12.5 mM 0.336814967424347 0.374569082205332 no 1258 0.368128194653989 1791 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1162 k048-0130 20.1 µM 0.332060466701997 0.376305056702666 no 1259 0.369921800489569 1729 6797406 SGTC_2460 5552655 174.22 µM 0.331437086907355 0.376532853122561 no 1260 0.370157177559751 1689 5401989 SGTC_2990 9074105 71.4286 µM 0.331119358075566 0.376648974639407 no 1261 0.370277165005852 1736 6502001 SGTC_314 1671-0008 2.74 µM 0.330763481102205 0.376779051549173 no 1262 0.370411573743894 1740 3913060 SGTC_648 0375-0473 33.3 µM 0.329736991961144 0.377154322831758 no 1263 0.370799349985398 1755 1713139 SGTC_983 1491-0821 12.2 µM 0.328269336808668 0.37769108027218 no 1264 0.3713540132047 1844 46495113 SGTC_2423 st077119 87.2 µM 0.326611230015696 0.378297774763835 no 1265 0.371980974331046 1718 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_923 1900-2434 73.3 µM 0.326607470099881 0.37829915084331 no 1266 0.371982396411916 1692 5910570 SGTC_2915 7971052 15.16 µM 0.326010114470896 0.378517794698034 no 1267 0.372208351299984 1801 5741558 SGTC_3293 9120939 62.045 µM 0.32480301256913 0.378959736273124 no 1268 0.372665082182954 1792 934087 SGTC_806 3966-4455 5.86 µM 0.323506141536047 0.379434720302361 no 1269 0.373155978556537 1680 714982 SGTC_1986 st071812 45 µM 0.323461341519371 0.379451131738377 no 1270 0.373172940108151 1745 11838594 SGTC_234 nsc-17383 10.7 µM 0.322703821349663 0.379728664361756 no 1271 0.373459778921457 1847 408974 SGTC_3050 9093513 49.47 µM 0.322600598971012 0.379766486739304 no 1272 0.373498870025341 1721 25236664 SGTC_1480 1070-0044 41.2 µM 0.322182858304559 0.379919565535099 no 1273 0.373657084899435 1827 3124987 SGTC_2729 fluphenazine 10.66 µM 0.32078263855475 0.380432805562353 no 1274 0.374187558547056 1696 3372 An atypical antipsychotic. SGTC_785 1270-0111 65.3 µM 0.319433507216036 0.380927518707998 no 1275 0.374698902786134 1727 6741994 SGTC_761 k216-0224 480 µM 0.319382727129997 0.380946143071622 no 1276 0.374718153631304 1929 1340404 SGTC_948 3448-0295 75.3 µM 0.318363279687095 0.381320099118575 no 1277 0.375104694448077 1723 678569 SGTC_3322 9139058 2.11 µM 0.318199687630129 0.381380118660718 no 1278 0.375166734848082 1812 4908926 YPR165W RHO1 SGTC_2641 levomentholum 100 µM 0.317919327652257 0.381482985285077 no 1279 0.375273065644038 1801 16666 SGTC_162 k030-0015 37.8 µM 0.317748842595068 0.381545541896171 no 1280 0.375337729335734 1896 1809920 YMR134W ERG29 SGTC_938 3126-1755 342 µM 0.317077496116239 0.381791911212345 no 1281 0.375592400014697 1884 1777771 SGTC_3079 9117512 49.47 µM 0.316195559148586 0.382115635346001 no 1282 0.375927039129037 1809 7185044 SGTC_1935 st074532 41.6 µM 0.315138723253909 0.38250366650649 no 1283 0.376328164197838 1918 2829742 SGTC_2453 5731132 22.18 µM 0.314960033241729 0.382569286561136 no 1284 0.376395999717004 1889 1362040 SGTC_720 r052-1644 49.9 µM 0.313227548183858 0.383205678905195 no 1285 0.377053895152325 1760 1422863 YOR257W CDC31 SGTC_2351 9026858 72.31 µM 0.312438625537033 0.383495577817678 no 1286 0.377353599790364 1688 1409300 SGTC_1987 st072290 61.9 µM 0.311080651320941 0.383994734133479 no 1287 0.377869654962552 1768 54697379 SGTC_1669 st015249 58.4 µM 0.310106730385681 0.384352840952417 no 1288 0.378239897143913 1908 722793 SGTC_1947 st076332 61.6 µM 0.309723881775366 0.384493639900161 no 1289 0.378385470096094 1871 24208416 SGTC_568 1193-0097 7.48 µM 0.308812160175767 0.384829002017152 no 1290 0.378732209243597 1808 3646150 SGTC_1998 st075797 76.8 µM 0.308185763112931 0.385059462059931 no 1291 0.378970492496208 1881 24208315 SGTC_2592 piperlongumine 83.33 µM 0.307829556346293 0.385190533515687 no 1292 0.379106015103542 1697 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_61 0978-8327 98.565 µM 0.307720270870204 0.385230749324865 no 1293 0.37914759689112 1834 6150059 YHR072W ERG7 SGTC_1521 st012942 49.4 µM 0.305685076284908 0.385979902817649 no 1294 0.379922218573245 1934 24207259 SGTC_2802 7925815 54.55 µM 0.305382714867199 0.386091238174314 no 1295 0.380037342483859 1725 1262923 SGTC_2194 5927483 104.545 µM 0.304900898457374 0.386268671732985 no 1296 0.380220815727556 1810 760979 SGTC_1333 1482-0047 286 µM 0.304528690766745 0.386405757107043 no 1297 0.380362568983952 1875 3811116 SGTC_3323 9138564 53.9225 µM 0.304272226619188 0.386500221987719 no 1298 0.38046025129842 1907 43912313 YNL103W MET4 SGTC_1618 st003135 44.5 µM 0.304139954930962 0.38654894499159 no 1299 0.380510634047924 1874 1270615 SGTC_196 k015-0023 18.111 µM 0.303872381990295 0.386647512423839 no 1300 0.380612559714996 1763 5211998 SGTC_1952 st077036 64.1 µM 0.303709381659926 0.386707561407821 no 1301 0.380674654949285 1799 2937007 SGTC_1655 st012546 55.1 µM 0.302818725448784 0.387035725179976 no 1302 0.381014006095433 1794 720985 YLR208W SEC13 SGTC_1741 st038134 10.228 µM 0.300829148480896 0.387769079539626 no 1303 0.381772390046079 1883 1272587 SGTC_1626 st003712 1.76 µM 0.297346763901077 0.389053642637853 no 1304 0.383100891375815 1827 24207035 SGTC_1228 0124-0032 52.5 µM 0.29727504646846 0.389080110177138 no 1305 0.383128265506456 1852 X1228 SGTC_3225 9130819 49.47 µM 0.296501250852837 0.389365714544151 no 1306 0.383423655924945 1855 4547121 SGTC_3130 9127414 49.47 µM 0.295469120743452 0.389746761987288 no 1307 0.383817768985663 1796 1494646 SGTC_3051 9093778 49.47 µM 0.29540873041916 0.389769060503697 no 1308 0.383840832416571 1823 17217378 SGTC_814 3342-0569 96 µM 0.295358317713084 0.389787675163365 no 1309 0.383860085649703 1806 4346283 SGTC_1431 4049-0260 9.09 µM 0.294384737306431 0.390147214781861 no 1310 0.38423196416855 1846 3854841 SGTC_1156 4092-0367 4.88 µM 0.292865506531152 0.390708448714613 no 1311 0.384812477600615 1808 1357585 SGTC_3010 9080089 71.4286 µM 0.292015262635192 0.391022645123341 no 1312 0.385137477214646 1887 17027233 SGTC_2459 5811157 9.22 µM 0.289706418479693 0.391876206355869 no 1313 0.386020422789341 1831 2870684 YBR192W RIM2 SGTC_2776 terbinafine 19.92 µM 0.287563915052836 0.392668738642691 no 1314 0.386840285099449 1821 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1793 st048256 72.231 µM 0.287119919219278 0.392833032705089 no 1315 0.387010250340051 1838 672022 SGTC_2125 5246583 200 µM 0.286927049344223 0.392904407287803 no 1316 0.387084089260068 1952 835267 SGTC_1343 1487-0095 224 µM 0.286304195976193 0.393134928720806 no 1317 0.38732257232975 1930 4560101 YGL055W OLE1 SGTC_677 0929-0063 136 µM 0.285320757118943 0.393498981085344 no 1318 0.387699205809117 1784 1539583 SGTC_2040 5100729 123 µM 0.284278705555029 0.393884832492458 no 1319 0.388098401874585 1839 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_3226 9131256 49.47 µM 0.284015859562347 0.393982175717221 no 1320 0.388199113365799 1827 17178073 SGTC_156 3474-0145 5.642 µM 0.283300274080442 0.394247221478464 no 1321 0.38847333360087 1946 2265471 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.282546424052203 0.39452649302273 no 1322 0.388762277364879 1839 4000243 SGTC_3027 9089541 49.47 µM 0.282361001695528 0.394595192967217 no 1323 0.388833357481753 1795 9943819 SGTC_594 1487-1584 10.8 µM 0.281886822848044 0.394770893595117 no 1324 0.389015146917915 1738 5013332 SGTC_1111 tnp00062 510.699 nM 0.281202487722535 0.395024502548733 no 1325 0.389277548346033 1924 676306 SGTC_3271 9137798 49.47 µM 0.279762207759272 0.395558403624085 no 1326 0.38982997407993 1926 6498326 SGTC_3245 9134821 49.47 µM 0.277200368329344 0.3965085423949 no 1327 0.390813128410532 1742 17014901 SGTC_2963 9082507 9 µM 0.275120976110856 0.397280202838518 no 1328 0.391611648294727 1850 16459611 SGTC_2383 9036125 200 µM 0.274380989720541 0.397554908272718 no 1329 0.391895925315772 1847 79580 SGTC_910 3454-3003 490 µM 0.274124658915775 0.397650077912976 no 1330 0.391994412159679 1950 820824 SGTC_907 3448-6986 75.5 µM 0.273703553708174 0.397806437662243 no 1331 0.392156223273823 1914 590582 SGTC_2750 bromebric acid 70.15 µM 0.273585132686247 0.397850411298385 no 1332 0.392201730317029 1821 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2749 bexarotene 57.39 µM 0.273361665377765 0.397933395624498 no 1333 0.392287608751833 1755 82146 An retinoic acid receptor inhibitor. SGTC_790 1575-0012 79.1 µM 0.27296049542868 0.398082381203944 no 1334 0.392441791430324 1942 378741 YLR208W SEC13 SGTC_2909 7941780 10.49 µM 0.272075797330624 0.398410990858237 no 1335 0.392781869368483 1970 1243215 SGTC_278 4092-0821 23.9 µM 0.271649873896159 0.39856922031184 no 1336 0.392945623541442 1889 877900 SGTC_616 4092-0450 108 µM 0.270779094004826 0.398892764657196 no 1337 0.393280469977296 1863 787165 SGTC_2379 9035213 200 µM 0.268699830615236 0.399665610142607 no 1338 0.394080341070631 1979 646551 SGTC_1197 1601-0112 267 µM 0.268598068119562 0.399703444563147 no 1339 0.394119499549064 1774 7350313 SGTC_120 rhodamine 6G 52.259 µM 0.268562727803729 0.399716584008909 no 1340 0.394133098846816 1825 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3147 9097027 49.47 µM 0.266587443271728 0.400451170270282 no 1341 0.394893412337867 1879 25236841 SGTC_2745 rifampicin 24.3 µM 0.265601964493675 0.400817790703242 no 1342 0.395272886240098 1966 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_169 k015-0017 16.025 µM 0.26547758692405 0.400864068193479 no 1343 0.395320786821182 1914 1840002 SGTC_2271 7849410 118.62 µM 0.26498936191061 0.401045736804396 no 1344 0.395508828465811 2007 972430 SGTC_3026 9090633 49.47 µM 0.264864527889481 0.401092191001747 no 1345 0.395556912651688 1806 25236842 SGTC_3000 9075062 71.4286 µM 0.263718033651976 0.401518898584134 no 1346 0.395998599238711 1817 17057871 SGTC_122 0236-0016 402.397 µM 0.261917616176681 0.402189223253299 no 1347 0.396692478926003 1842 6808838 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.259802328435407 0.402977146776207 no 1348 0.39750812739193 1819 688803 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.259293062944729 0.403166902067026 no 1349 0.39770456569973 1845 16486 A toxic proline analog. SGTC_2066 5222451 176 µM 0.256676006345746 0.404142391393019 no 1350 0.398714447647979 1857 2281147 SGTC_150 3970-0969 77.2 µM 0.255389852877995 0.404622014935062 no 1351 0.399211003618275 1872 6615640 SGTC_2640 pentamidine 10.38 µM 0.255246566254767 0.404675457288939 no 1352 0.39926633359047 1989 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2986 9022445 71.43 µM 0.254681369689754 0.404886278911321 no 1353 0.399484603347457 1979 6459286 SGTC_428 3448-4153 16.5 µM 0.254355472404614 0.405007853057426 no 1354 0.399610473885739 1744 3834874 SGTC_3124 9127567 49.47 µM 0.252874610006403 0.405560395748573 no 1355 0.400182555112019 1958 17592030 SGTC_2525 harmine 47.85 µM 0.252827347460423 0.405578033561012 no 1356 0.400200816936739 1919 5280953 A monoamine oxidase inhibitor SGTC_1461 k072-0203 53.8 µM 0.252468766684727 0.405711857826706 no 1357 0.400339376444437 1897 5418714 SGTC_617 3770-0098 35 µM 0.251213648050138 0.406180361522005 no 1358 0.400824466611489 1860 5962639 SGTC_2222 6885208 172.143 µM 0.250786595620013 0.4063397999467 no 1359 0.400989552804925 1896 609514 SGTC_3167 9103034 49.47 µM 0.250509203029171 0.406443371753369 no 1360 0.401096794280979 1869 5127859 SGTC_2170 morpholine 200 µM 0.250030398636291 0.406622161341246 no 1361 0.401281920178294 1946 121171 Reacts with secondary amines. SGTC_3002 9075603 71.4286 µM 0.249882519853842 0.406677384458857 no 1362 0.401339100810934 1944 20105405 SGTC_439 amiodarone 34.4 µM 0.249869263793537 0.406682334826793 no 1363 0.401344226665806 1924 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.249338897366556 0.406880408082097 no 1364 0.40154932273439 1832 6857784 SGTC_3333 9141820 12.094 µM 0.248476541489873 0.407202518585558 no 1365 0.401882859115029 1830 1939433 SGTC_733 4069-0007 56.1 µM 0.247948665868568 0.407399723715124 no 1366 0.402087062686948 1904 5717425 YNL287W SEC21 SGTC_458 nppb 133 µM 0.24439400430722 0.408728292113849 no 1367 0.403462842444916 2022 4549 A chloride channel blocker. SGTC_3281 9140613 49.47 µM 0.244293315652507 0.408765940241387 no 1368 0.403501830007356 1780 16013766 SGTC_591 4299-0174 154 µM 0.244236796576059 0.408787073451984 no 1369 0.403523715127825 1905 5509088 SGTC_205 1486-1330 71.903 µM 0.243360020530186 0.409114945237457 no 1370 0.403863255956357 1887 4118834 SGTC_1681 tripelennamine 100 µM 0.243110118586427 0.40920840811998 no 1371 0.403960046415879 1893 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1839 st053978 48 µM 0.240984656975646 0.410003535099997 no 1372 0.404783504053969 2001 3788398 SGTC_341 1486-1430 230 µM 0.240663869168066 0.410123572811846 no 1373 0.404907822099956 1827 2054753 YPL210C SRP72 SGTC_644 1498-1197 63.3 µM 0.240207862003958 0.410294223642346 no 1374 0.405084559546076 1933 6741615 SGTC_3353 9151644 39.2805 µM 0.239552232391851 0.410539608624355 no 1375 0.405338699787233 1879 4909158 SGTC_2583 asiatic acid 100 µM 0.238493212280965 0.410936046035464 no 1376 0.405749289655033 1908 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1819 st053448 58.6 µM 0.237919566960385 0.411150824512779 no 1377 0.405971739488534 1914 2857616 SGTC_663 1486-0733 13.9 µM 0.237513296641014 0.411302952251048 no 1378 0.406129302532707 1889 722445 YPR165W RHO1 SGTC_2836 9010338 19.48 µM 0.234701919595611 0.412356035420548 no 1379 0.407220048864035 1746 2994051 SGTC_934 2950-0684 338 µM 0.234329946867405 0.412495416094727 no 1380 0.407364419396985 2001 1121253 SGTC_576 1073-0113 22.7 µM 0.23336754196248 0.412856086833853 no 1381 0.407738007579281 2022 5439563 SGTC_57 miconazole 162.5 nM 0.232102558663377 0.413330263681867 no 1382 0.408229178807524 1824 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1005 4092-0690 4.4 µM 0.230892394488911 0.413784010031447 no 1383 0.408699199715598 1855 1529343 SGTC_1193 1488-0126 41.5 µM 0.22992224456533 0.414147847150786 no 1384 0.409076095337134 1868 1384710 SGTC_1963 st076565 50.3 µM 0.229720339813011 0.414223577137983 no 1385 0.409154544327949 1871 4914280 SGTC_1291 0993-0025 5.79 µM 0.229622842789965 0.414260147247409 no 1386 0.409192427567693 1981 4353356 SGTC_3272 9137413 49.47 µM 0.228572020540933 0.414654346755679 no 1387 0.409600786628185 1886 17614870 SGTC_2861 9024595 19.48 µM 0.22780595615028 0.414941778015306 no 1388 0.409898548048692 2034 16482810 SGTC_2674 ligustilide 100 µM 0.227617544597951 0.415012477972235 no 1389 0.409971789667557 1927 5319022 A signalling regulator. SGTC_914 3820-6779 408 µM 0.226948514355765 0.415263548546496 no 1390 0.410231888562935 1894 2893481 SGTC_846 0335-0850 148 µM 0.225781463020209 0.415701596948848 no 1391 0.410685697596917 1975 6819598 SGTC_3138 9097216 49.47 µM 0.225301100338485 0.415881929773334 no 1392 0.410872521864284 2088 25237486 SGTC_1176 0848-0131 83.3 µM 0.224601859949663 0.416144463068766 no 1393 0.411144508913028 2038 6769040 SGTC_2205 7238770 200 µM 0.223326305669513 0.416623472606941 no 1394 0.411640777625907 2007 279867 SGTC_981 1488-1094 54.9 µM 0.223050374821492 0.41672710937211 no 1395 0.411748150247528 1900 3449522 SGTC_2961 9083290 32.55 µM 0.221449307514641 0.417328567656468 no 1396 0.412371301719198 1978 17741490 SGTC_1462 k081-0014 26.5 µM 0.220632806868222 0.417635369562204 no 1397 0.412689177147139 1950 3270634 SGTC_284 0988-0104 32.6 µM 0.220344156861724 0.417743842440419 no 1398 0.412801566452196 2003 4666532 SGTC_2772 vinpocetine 57.06 µM 0.219870287693809 0.41792193309601 no 1399 0.412986088531949 1983 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3228 9131799 49.47 µM 0.219627720600265 0.418013101762916 no 1400 0.413080550282697 1934 17015818 SGTC_2564 betulinic acid 100 µM 0.218831906486954 0.418312238836174 no 1401 0.413390495703076 2097 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2116 5511452 16.8835 µM 0.216875162964612 0.419047956078145 no 1402 0.414152817014845 1947 870744 SGTC_1206 3978-0017 132 µM 0.21624641440146 0.41928441988781 no 1403 0.414397837936073 1962 3873677 SGTC_3351 9150312 21.596 µM 0.215751004348761 0.419470757432698 no 1404 0.414590920819544 2026 4904905 SGTC_2868 9035608 32.47 µM 0.213502346732676 0.420316766738664 no 1405 0.415467579444114 1901 6462614 SGTC_2822 7994718 71.43 µM 0.212974496477838 0.420515412614091 no 1406 0.415673427597749 1988 1018011 SGTC_9 0092-0002 10.449 µM 0.212251126545816 0.420787671276994 no 1407 0.415955561022377 1982 759368 SGTC_316 k060-0003 58.6 µM 0.211913687615044 0.420914687965395 no 1408 0.416087185965277 2007 6152314 SGTC_2280 7785178 200 µM 0.210394740353529 0.421486542510506 no 1409 0.416679798689452 1929 2954328 SGTC_3163 9099914 49.47 µM 0.208988559970174 0.422016090166237 no 1410 0.417228584627785 2052 16268368 SGTC_984 1492-0255 2.91 µM 0.207891195717762 0.42242944005215 no 1411 0.417656961896705 1947 1585198 SGTC_266 formosanin C 406 nM 0.205279024806001 0.423413722972116 no 1412 0.418677065438078 2034 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1251 0490-5699 265 µM 0.205142921288252 0.423465020817252 no 1413 0.418730231563345 2060 3883818 SGTC_230 MPP+ 141.667 µM 0.204839370570438 0.423579434712102 no 1414 0.418848812944358 1894 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_847 0342-0274 5.54 µM 0.202731638000551 0.424374055393507 no 1415 0.419672396543004 2047 18097 SGTC_1934 st074720 32.6 µM 0.201889410315529 0.424691663595934 no 1416 0.420001590480185 1871 17250992 SGTC_547 1120-0019 610 nM 0.200361071737911 0.425268132330472 no 1417 0.420599101196864 1930 3676939 SGTC_2118 5526350 200 µM 0.200075510843445 0.42537585981181 no 1418 0.420710762820247 1975 743594 SGTC_3053 9095903 49.47 µM 0.199158783479225 0.425721731648666 no 1419 0.421069269770098 2079 17174018 SGTC_2361 9034121 116 µM 0.199133179200259 0.425731392702388 no 1420 0.421079283842965 1936 6496917 SGTC_996 3970-0799 1.8 µM 0.197917569059875 0.426190120165698 no 1421 0.421554778976943 2052 6615648 YGL040C HEM2 SGTC_521 r062-0005 13.8 µM 0.197285421450227 0.426428709411637 no 1422 0.421802093574813 1906 2832033 SGTC_987 1497-1013 404 µM 0.197026062749245 0.426526606047813 no 1423 0.421903571198734 2016 1676435 SGTC_2976 9009005 19.48 µM 0.196628346807355 0.42667673531972 no 1424 0.42205919304823 2085 2993148 SGTC_2331 7980721 200 µM 0.196199759557365 0.426838529742813 no 1425 0.422226908122626 2039 2981221 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.195366112216901 0.427153272171796 no 1426 0.422553171975851 2074 5024745 SGTC_1835 st008666 49.2 µM 0.194813782755708 0.427361828970566 no 1427 0.422769365970715 1905 690455 SGTC_1146 3579-1023 7 µM 0.194684358816718 0.427410701730543 no 1428 0.422820028736124 2071 X1146 SGTC_2853 9015042 58.44 µM 0.194148032968293 0.427613239686566 no 1429 0.423029986110127 1964 6457456 SGTC_1021 4476-0760 85.3 µM 0.191993569987945 0.428427042251459 no 1430 0.423873621068988 1868 746768 SGTC_1817 st052116 64.4 µM 0.19090701782779 0.428837579927418 no 1431 0.424299220932758 2049 4361398 SGTC_2037 5169046 200 µM 0.190779419759941 0.428885796032562 no 1432 0.424349206590925 1997 5718022 SGTC_1770 st043884 66.3 µM 0.190500384554808 0.428991240125494 no 1433 0.42445852093634 2060 670149 SGTC_1944 st076371 56.9 µM 0.189580630833084 0.429338839986099 no 1434 0.424818883150465 1894 24208455 SGTC_1321 1326-2144 215 µM 0.188926203743159 0.429586199102651 no 1435 0.42507532789042 2070 3513030 SGTC_2124 5246320 200 µM 0.187851602224974 0.429992434884648 no 1436 0.425496491517928 1978 579342 SGTC_1086 cerivastatin 2.18 µM 0.186793060902353 0.430392671842149 no 1437 0.425911443879586 2085 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1945 st075991 56.6 µM 0.18621083836254 0.430612842064681 no 1438 0.426139712412079 1909 1084980 SGTC_724 3910-0327 137 µM 0.185962130470081 0.430706898716184 no 1439 0.426237229386515 1946 2885483 SGTC_357 1325-0123 420 µM 0.185838448551027 0.430753674357674 no 1440 0.426285726055185 2086 1098503 SGTC_2489 cantharidin 73.42 µM 0.185349501328424 0.4309386003016 no 1441 0.42647745707471 2033 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2608 thymoquinone 42.66 µM 0.184833233369143 0.431133875724065 no 1442 0.426679920242098 2093 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2263 7948595 193.29 µM 0.18479862916297 0.431146965171012 no 1443 0.426693491555318 1925 2971371 SGTC_1709 st033179 39.1045 µM 0.183073549801091 0.431799592240848 no 1444 0.427370154606167 2050 573381 SGTC_3338 9144300 39.5675 µM 0.182379139593316 0.432062352174304 no 1445 0.427642597724493 2026 4901274 SGTC_2985 9022375 71.43 µM 0.181405355954308 0.432430875648098 no 1446 0.428024707591078 1990 4939335 SGTC_2132 5317594 122.667 µM 0.18086525006914 0.432635301345152 no 1447 0.428236672695644 1992 794577 SGTC_1009 4106-0057 9.87 µM 0.179790974331432 0.433041959549145 no 1448 0.428658334797748 2123 2928005 SGTC_783 0848-0141 92.7 µM 0.179311404226797 0.433223519770098 no 1449 0.428846596349746 1991 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1500 4488-1866 171 µM 0.17768995484825 0.433837487699552 no 1450 0.42948323728823 2085 2900003 SGTC_1786 berberine 21.6 µM 0.17620110074151 0.434401388583867 no 1451 0.430067978025363 2039 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2417 cerulenin 830 nM 0.175838438390161 0.434538766576748 no 1452 0.430210435313394 2135 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1137 ixabepilone 100 µM 0.174543880371971 0.435029214843201 no 1453 0.430719024222039 1940 154225 A novel microtubule stabilizer. SGTC_1477 0139-0234 16 µM 0.174523748210199 0.435036842781274 no 1454 0.430726934390391 2085 620880 SGTC_143 4032-1194 15.74 µM 0.174308772867954 0.435118296971534 no 1455 0.430811402518687 1936 1806963 SGTC_1547 harmine 94.2 µM 0.173387364773229 0.435467449789789 no 1456 0.431173478069763 2054 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1272 0839-0021 27 µM 0.171154412851448 0.43631379929034 no 1457 0.432051175881553 2024 5027250 SGTC_2457 5731572 11.68 µM 0.17020247005128 0.436674700400911 no 1458 0.432425454621605 2116 2865357 SGTC_1056 3448-1962 115 µM 0.169846643469924 0.436809615133481 no 1459 0.43256537181444 2017 715507 SGTC_1562 morin hydrate 59.1 µM 0.169504024762068 0.43693952893247 no 1460 0.43270010343346 2003 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1422 4031-0024 15.5 µM 0.168686240326172 0.437249643032464 no 1461 0.433021721153006 2105 782427 SGTC_949 1165-0505 146 µM 0.167862778185722 0.437561949149038 no 1462 0.433345616628977 1953 6244267 SGTC_2846 9008642 19.48 µM 0.167822191784103 0.437577342948629 no 1463 0.433361581791273 1970 2992898 SGTC_3014 9081533 49.47 µM 0.167207172401665 0.437810621917362 no 1464 0.433603520554735 2120 21367265 SGTC_752 1896-0090 130 µM 0.16591451169954 0.438301002938564 no 1465 0.434112113547317 2040 772567 SGTC_1326 1431-2094 10.8 µM 0.16582334752738 0.43833559037094 no 1466 0.434147985911041 1938 616278 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.164109038767543 0.438986081746507 no 1467 0.434822653189197 2086 3256 An antibiotic and ribosome inhibitor. SGTC_957 1187-1561 14.1 µM 0.16395155806758 0.43904584580723 no 1468 0.434884639366114 2121 1538454 SGTC_1475 4092-1048 11.7 µM 0.163667997247207 0.439153460884574 no 1469 0.434996256132602 2028 2881759 SGTC_94 0334-0113 514.748 µM 0.163542144608504 0.439201225065029 no 1470 0.435045796599315 1986 6795178 SGTC_755 1995-0008 37.3 µM 0.162763104797874 0.439496909561171 no 1471 0.435352479464753 2115 689533 SGTC_1166 k206-0078 225 µM 0.162677049748024 0.43952957382167 no 1472 0.435386358952862 2036 5404595 SGTC_1008 4106-0037 6 µM 0.162287641998977 0.439677388026466 no 1473 0.435539672966826 2029 2905394 SGTC_2299 7976368 114.88 µM 0.161198908929917 0.440090701746212 no 1474 0.435968370214047 2096 2979718 SGTC_1771 st048882 4.1505 µM 0.161039550673752 0.440151204114676 no 1475 0.436031125110977 1932 4580403 SGTC_379 3970-0972 5.9 µM 0.16002956039127 0.440534692081221 no 1476 0.436428894233225 2023 2898042 YBL034C STU1 SGTC_2689 tacrolimus 100 µM 0.15932413352411 0.440802572037635 no 1477 0.436706753903699 1986 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1256 0570-0116 285 µM 0.159273127678845 0.440821942132711 no 1478 0.436726845742022 1985 410638 SGTC_2918 7977171 22.06 µM 0.159100413265768 0.440887533599748 no 1479 0.436794881314333 2057 2236483 SGTC_1938 st074717 56.4 µM 0.15898500119437 0.440931364355241 no 1480 0.436840345420007 2087 17250979 SGTC_2325 6158266 200 µM 0.158529230318942 0.441104462342789 no 1481 0.437019894709682 2011 3623240 SGTC_3202 9113761 49.47 µM 0.154900417460372 0.442483054021993 no 1482 0.438449912267171 2118 4798415 SGTC_1001 4048-4355 44.4 µM 0.154706776091105 0.442556638411264 no 1483 0.438526243883775 2045 21824233 SGTC_2063 5246145 200 µM 0.154585920644304 0.4426025649031 no 1484 0.438573885129677 2073 711240 SGTC_599 1935-0052 86.5 µM 0.154065244247087 0.442800436872813 no 1485 0.438779146058489 2103 9557311 SGTC_3176 9106582 49.47 µM 0.152249599580807 0.443490545247972 no 1486 0.43949503754934 2131 17018027 SGTC_581 0958-0271 211 µM 0.152072877375078 0.443557724778755 no 1487 0.43956472804758 2026 4591145 SGTC_3088 9117578 49.47 µM 0.151977121367528 0.443594126335664 no 1488 0.439602490263895 2141 678341 SGTC_700 3453-2283 142 µM 0.151441748298466 0.443797656669458 no 1489 0.439813629416694 2112 565664 SGTC_198 3454-2873 16.191 µM 0.150170954211813 0.444280827915003 no 1490 0.440314870591646 2036 710957 SGTC_1970 st070122 35.8 µM 0.148797800556664 0.444803010579229 no 1491 0.440856593110187 2102 102928 SGTC_3193 9111931 49.47 µM 0.148214189344748 0.445024975227371 no 1492 0.441086867009218 2043 17087244 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.147243755285389 0.445394098202138 no 1493 0.441469812615546 2165 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2210 7115885 190.385 µM 0.146252699824257 0.445771113780129 no 1494 0.441860952166135 2083 2927039 SGTC_2673 kobusone 100 µM 0.145332259717051 0.446121309921171 no 1495 0.442224272766735 2119 6710676 An epoxy ketone and protein crosslinker. SGTC_2635 hydroquinidine 100 µM 0.144735672236401 0.446348313625127 no 1496 0.442459786661772 2048 442912 An experimental heart treatment. SGTC_3120 9124077 49.47 µM 0.141199933472992 0.447694033525265 no 1497 0.443855999315015 2184 18774327 YGL155W CDC43 SGTC_610 4215-0184 155 µM 0.141155787265071 0.44771083963246 no 1498 0.443873436463575 2081 5605015 SGTC_1270 0831-1170 17.3 µM 0.140159879129492 0.448089998758363 no 1499 0.444266835372792 2140 6764716 SGTC_2080 5212524 12.4 µM 0.140110646415202 0.448108743721211 no 1500 0.444286284473791 2190 260183 SGTC_108 0509-0257 621.132 µM 0.140061490279728 0.448127459642887 no 1501 0.444305703456618 2141 536624 SGTC_1214 0358-0031 63.7 µM 0.139627756753269 0.448292606239491 no 1502 0.444477054365224 2158 4301366 SGTC_1622 st003707 19.4 µM 0.139419449036863 0.44837192381751 no 1503 0.444559352170453 2074 10140899 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.138980280069884 0.44853915346838 no 1504 0.444732866014227 2153 16725076 SGTC_23 0213-0011 39.996 µM 0.13879384988454 0.448610146348409 no 1505 0.444806527014067 2161 627608 SGTC_2680 butyl paraben 22.24 µM 0.138644742599337 0.448666927799445 no 1506 0.444865442620831 2160 7184 An antifungal and steroid mimetic. SGTC_1038 k292-0204 154 µM 0.138008447014879 0.448909246922631 no 1507 0.445116870839925 2118 4454212 SGTC_409 arachidonic acid 100 µM 0.137576333627442 0.449073818636687 no 1508 0.445287630336283 2113 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2911 7942208 15.64 µM 0.137173804601185 0.449227130938869 no 1509 0.445446708028718 2023 1243384 SGTC_1910 st062352 60.4 µM 0.137167856797915 0.449229396351428 no 1510 0.445449058640205 2090 2245730 SGTC_3082 9117008 49.47 µM 0.135655788497578 0.449805369785513 no 1511 0.446046700099967 2032 41448529 SGTC_2112 5488546 200 µM 0.13539268714857 0.449905600557118 no 1512 0.446150702852956 2117 600757 SGTC_1312 1218-2183 165 µM 0.135017461153939 0.45004855172534 no 1513 0.446299034370447 2186 6744073 SGTC_960 1222-0186 7.7 µM 0.131782983403185 0.451281068915777 no 1514 0.44757797321543 2102 3126296 SGTC_526 4469-0568 170 µM 0.131004015121495 0.451577970111982 no 1515 0.447886065586618 2022 2901964 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.128897642982373 0.45238094210533 no 1516 0.448719320869604 2096 688664 SGTC_1680 diphenhydramine 100 µM 0.128750276829042 0.452437127016654 no 1517 0.448777625644278 2026 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2019 4016004 108 µM 0.127214513357541 0.453022709627201 no 1518 0.449385309355829 2069 45595336 SGTC_477 mead ethanolamide 10 µM 0.125928535230992 0.453513128389485 no 1519 0.449894247313941 2184 16061185 SGTC_1265 0819-1001 68.8 µM 0.125655293570217 0.453617340592913 no 1520 0.450002395920588 2183 3106768 SGTC_227 fluconazole 33.516 µM 0.125622191977377 0.453629965495062 no 1521 0.450015497729731 2043 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2794 7785382 27.27 µM 0.124583054262183 0.454026314955951 no 1522 0.450426822302488 2232 2205081 SGTC_1131 3454-3128 32.3 µM 0.122997043051612 0.454631341866405 no 1523 0.451054719745699 2105 710982 SGTC_2060 5238662 140 µM 0.119853607179008 0.45583080032298 no 1524 0.452299557788056 2096 790130 SGTC_3303 9125618 40.5795 µM 0.119262091176927 0.456056553748224 no 1525 0.452533857976364 2136 22695467 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.11915130018444 0.456098838961722 no 1526 0.452577744259926 2189 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_20 0481-0013 4.944 µM 0.118909217998068 0.456191235358981 no 1527 0.452673639336816 2111 182045 SGTC_3043 9092303 49.47 µM 0.118780918378004 0.456240204907015 no 1528 0.452724463286874 2101 25236084 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.115679965321828 0.457423980712924 no 1529 0.453953092497629 2199 77254 SGTC_1324 1418-0026 34.4 µM 0.112804745036898 0.458521921810538 no 1530 0.45509267818149 2124 1372513 SGTC_395 anisomycin 6.25 µM 0.111701481275163 0.458943302234294 no 1531 0.455530052397369 2094 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1104 tacrolimus 29.8 µM 0.109812570590891 0.459664859400748 no 1532 0.456279010725222 2200 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2219 9098279 200 µM 0.109441925305158 0.459806460251439 no 1533 0.456425990927084 2216 902349 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.108782795213558 0.4600582860518 no 1534 0.456687385128446 2073 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_361 000s-0510 1.45 µM 0.10765093427875 0.460490759689433 no 1535 0.457136296003383 2124 660 SGTC_2386 9075165 157.42 µM 0.10721845820769 0.460656017181844 no 1536 0.457307836153371 2129 16452277 SGTC_2930 9013230 14.89 µM 0.105150979575096 0.461446134256595 no 1537 0.458128003815511 2185 2995857 SGTC_45 0kpi-0036 14.9 µM 0.103123576220391 0.462221083806958 no 1538 0.458932446828568 2145 2795021 SGTC_2682 pyrogallin 40.03 µM 0.0994948584289577 0.463608471944825 no 1539 0.46037268501247 2230 822798 An ATP competetive kinase inhibitor. SGTC_2359 9039622 200 µM 0.0990719424502345 0.46377019692343 no 1540 0.460540574573778 2168 6463596 SGTC_2818 7996756 12.99 µM 0.0990472148754034 0.463779653045145 no 1541 0.460550391166389 2195 2241621 SGTC_2807 7945238 51.95 µM 0.0990286485802049 0.46378675303295 no 1542 0.460557761810226 2162 17148797 SGTC_1982 st072467 71.9 µM 0.0986411271126185 0.463934948808149 no 1543 0.460711607262301 2086 3163533 SGTC_2860 9025725 38.96 µM 0.0971486844413938 0.464505734589263 no 1544 0.461304159540212 2064 40546248 SGTC_2398 5228213 48.84 µM 0.0970132344617197 0.46455754116558 no 1545 0.461357942222681 2248 80771 YMR134W ERG29 SGTC_2120 5538279 151.968 µM 0.0946051511233729 0.465478678461889 no 1546 0.462314229092872 2167 2058197 SGTC_1118 chelidonine 707.474 nM 0.0937966809644389 0.465787975272173 no 1547 0.462635334134688 2245 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1374 2889-5571 141 µM 0.0919860604273432 0.466480739917827 no 1548 0.463354557400122 2151 2853281 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0902013988439327 0.467163671767636 no 1549 0.464063586371858 2226 688798 SGTC_353 1988-1175 58.3 µM 0.0896534470078487 0.467373374575819 no 1550 0.464281305401449 2161 2788357 SGTC_277 nystatin 15.5 µM 0.089506004351287 0.467429802870502 no 1551 0.464339890978061 2251 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2187 6125751 200 µM 0.0881713921819833 0.467940606599624 no 1552 0.464870227236235 2195 874498 SGTC_163 TUB2.036 7.546 µM 0.0878732840072835 0.468054710484427 no 1553 0.464988695359228 2268 15992207 YJR013W GPI14 SGTC_1884 5633444 25 µM 0.0865317474648993 0.468568229357161 no 1554 0.465521859942133 2194 5724239 SGTC_2790 5423970 71.43 µM 0.0861071659369159 0.468730763355915 no 1555 0.465690613595457 2235 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2377 9073351 62.6 µM 0.0853370638358854 0.469025579320372 no 1556 0.465996713154864 2131 7337946 YHR072W ERG7 SGTC_3296 9122258 64.045 µM 0.0850523760688898 0.469134569825016 no 1557 0.466109875720475 2183 4730474 SGTC_3019 9081971 49.47 µM 0.0848858608172725 0.46919831997086 no 1558 0.466176066322973 2240 16451803 SGTC_703 3875-0075 71.8 µM 0.0842057419007255 0.469458710788924 no 1559 0.466446426514204 2182 2850814 SGTC_2920 7982904 15.77 µM 0.0838841707251221 0.469581832315852 no 1560 0.466574262565076 2191 6456808 SGTC_2775 cyproheptadine 69.59 µM 0.0836063364487613 0.469688210425003 no 1561 0.46668471441046 2264 2913 A selective serotonin reuptake inhibitor. SGTC_127 0180-0333 59.125 µM 0.0832960700134661 0.469807008823574 no 1562 0.466808062555933 2264 771601 SGTC_2798 7813637 45.45 µM 0.0808559530172911 0.470741401867457 no 1563 0.467778254809035 2210 956368 SGTC_542 3381-0244 89.3 µM 0.0805801400835001 0.470847029035994 no 1564 0.467887930376591 2264 1112843 SGTC_2619 obliquin 87.91 µM 0.0804365319302955 0.470902026988682 no 1565 0.467945036371572 2223 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1732 st034308 51.822 µM 0.0801277387478628 0.471020288119425 no 1566 0.468067830670935 2110 830119 SGTC_557 1315-0110 16.2 µM 0.0798690786863242 0.471119351313199 no 1567 0.468170691436924 2262 6833801 SGTC_1150 3909-7983 10.9 µM 0.0794777829827957 0.471269215501403 no 1568 0.468326301157573 2136 23965914 SGTC_1366 1683-0113 21.9 µM 0.0794524054596357 0.471278935099483 no 1569 0.468336393409398 2242 708623 SGTC_2811 7967822 32.47 µM 0.0793309073212274 0.471325469155532 no 1570 0.468384711637823 2230 2232244 SGTC_1862 st057513 3.81 µM 0.0787181667321646 0.471560156110701 no 1571 0.468628397678028 2245 5393163 SGTC_2260 7964312 200 µM 0.078555175975893 0.47162258518097 no 1572 0.468693220847424 2266 231951 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.078424170451555 0.47167276370438 no 1573 0.468745323749254 2242 2333 A French combination drug. SGTC_2847 9005661 71.43 µM 0.0767166843692949 0.47232681612012 no 1574 0.469424465724899 2279 2991449 SGTC_852 0418-0143 439 µM 0.0748588929081764 0.473038527713845 no 1575 0.470163491725684 2271 5369229 SGTC_2074 5212007 75.395 µM 0.0735201416876232 0.473551450811356 no 1576 0.470696108348593 2283 758611 SGTC_1634 st006576 41 µM 0.0732044882724303 0.473672395255805 no 1577 0.470821697424169 2270 3915356 SGTC_2053 5265679 138 µM 0.0729435975075035 0.473772358904129 no 1578 0.470925500266242 2264 764595 SGTC_3146 9095609 49.47 µM 0.0726278689726533 0.473893336556641 no 1579 0.471051124522521 2231 17173999 SGTC_343 4130-2827 29.8 µM 0.0726234543265803 0.473895028132969 no 1580 0.471052881072928 2172 1118244 SGTC_684 1140-0066 328 µM 0.0691523094584398 0.475225222817534 no 1581 0.472434191860072 2203 6813534 SGTC_1791 st048313 56.1 µM 0.0691319538722424 0.475233024212002 no 1582 0.472442293176171 2303 1204976 SGTC_425 3825-7017 13.1 µM 0.0687956960919901 0.475361898295224 no 1583 0.472576121996955 2212 3397440 SGTC_3295 9122362 53.5725 µM 0.0687526683565795 0.475378389281983 no 1584 0.472593247032161 2188 4730473 SGTC_149 3970-0822 46.1 µM 0.0684133576649706 0.475508436368066 no 1585 0.472728294432341 2276 3114250 YBL034C STU1 SGTC_660 4031-1742 102 µM 0.0679892590378586 0.475670983662541 no 1586 0.472897092272937 2248 6738706 SGTC_1689 st020265 53.493 µM 0.066816167131441 0.47612062394086 no 1587 0.473364026330823 2283 5758320 YPR016C TIF6 SGTC_1377 2944-0135 198 µM 0.0651198288106633 0.476770875589828 no 1588 0.474039296416038 2254 1894137 SGTC_739 1486-1183 203 µM 0.0640385843011245 0.477185377791184 no 1589 0.474469752007006 2308 4346692 SGTC_2885 9057732 51.95 µM 0.063891857034252 0.477241628567025 no 1590 0.474528168088928 2225 6471414 SGTC_3286 9117135 37.221 µM 0.0630928392279802 0.47754795564487 no 1591 0.47484628820418 2225 3438150 SGTC_1109 tnp00067 928.257 nM 0.0614075721208473 0.478194095849851 no 1592 0.475517311031094 2176 676295 SGTC_1012 4112-3522 18 µM 0.061182022126259 0.47828057728132 no 1593 0.475607123586296 2297 3112398 SGTC_1902 st060212 70.5 µM 0.0605792845491726 0.478511686742741 no 1594 0.475847135876495 2314 688944 SGTC_63 0099-0242 26.702 µM 0.0603868812245239 0.478585462046723 no 1595 0.475923753427935 2307 3898502 YLR359W ADE13 SGTC_3017 9080681 49.47 µM 0.0592763998802823 0.479011280273235 no 1596 0.476365979110922 2219 16451914 SGTC_24 0417-1663 219 µM 0.0590460876600257 0.479099597371523 no 1597 0.476457699739021 2232 4329390 SGTC_1130 3454-2858 15.9 µM 0.0581971776999274 0.479425135016138 no 1598 0.476795784391614 2154 715628 YIL048W NEO1 SGTC_2491 paeonol 100 µM 0.0581233209514821 0.479453458049957 no 1599 0.476825199179715 2206 11092 Increases levels of cortical cytochrome oxidase. SGTC_2312 7706453 155.7 µM 0.0571491390578437 0.479827052885461 no 1600 0.477213196524088 2254 976098 SGTC_1070 indatraline 8.81 µM 0.0571185080603541 0.47983880003881 no 1601 0.477225396595632 2217 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1252 0493-0875 34.8 µM 0.0552217592592864 0.480566247182109 no 1602 0.47798089700044 2293 3960963 SGTC_2408 sulbentine 18.36 µM 0.0535360361147467 0.481212815491757 no 1603 0.478652409569119 2176 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_766 1391-0721 126 µM 0.0530184994354851 0.481411329503888 no 1604 0.478858584012395 2309 1020919 YIL115C NUP159 SGTC_1811 st050069 61.5 µM 0.0528479221780923 0.481476759648368 no 1605 0.478926539222948 2322 3877702 SGTC_3143 9086658 49.47 µM 0.0500390476602465 0.482554260167445 no 1606 0.480045635874235 2216 25236626 SGTC_3060 1327-0027 12.5 µM 0.0494578319163197 0.482777234063068 no 1607 0.480277220652457 2325 16000455 YPR107C YTH1 SGTC_204 PMA1.184 62.41 µM 0.0492836120774426 0.482844071701811 no 1608 0.480346639657298 2325 2252213 YGL008C PMA1 SGTC_3215 9129942 49.47 µM 0.0488636706240272 0.483005179873886 no 1609 0.480513970450905 2325 17682944 SGTC_964 1287-0107 19.4 µM 0.0475690605620613 0.483501867077861 no 1610 0.481029845099303 2302 51516812 YPR165W RHO1 SGTC_804 1595-0054 20.9 µM 0.0474512306412791 0.483547074724803 no 1611 0.48107679941369 2236 761523 Stimulates phospholipase C. SGTC_2443 5493264 126.67 µM 0.0464207770386219 0.483942436419415 no 1612 0.481487438340023 2305 5340055 SGTC_3158 9100007 49.47 µM 0.0458569967205859 0.484158752857605 no 1613 0.481712114870107 2288 19297233 SGTC_340 k038-0059 454 µM 0.0457633625408271 0.484194679737474 no 1614 0.481749430328143 2329 23733424 SGTC_2507 purpurin 79.67 µM 0.0453125360518593 0.484367660980577 no 1615 0.48192909768905 2334 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1409 3909-8004 61.9 µM 0.0450533121890028 0.484467126004632 no 1616 0.482032407540547 2266 2119279 SGTC_858 0438-0351 2.77 µM 0.0447257692347643 0.48459280666366 no 1617 0.482162946683966 2250 2799119 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0432430154141126 0.485161769258458 no 1618 0.482753907899106 2218 689007 SGTC_2865 9030313 51.95 µM 0.0430629068031966 0.485230882651682 no 1619 0.48282569396862 2321 42562754 SGTC_1310 1188-0297 994 nM 0.0426497969747188 0.485389407683355 no 1620 0.482990349666193 2283 1588352 SGTC_1555 citronellol 128 µM 0.0421847321366927 0.485567872474011 no 1621 0.483175716857928 2337 8842 A terpine precursor. SGTC_619 1652-1634 108 µM 0.0412918264342716 0.48591052573507 no 1622 0.483531624537638 2289 5400454 SGTC_2313 7726885 200 µM 0.0404715087406433 0.486225332465896 no 1623 0.483858610577984 2304 726423 SGTC_3279 9140807 49.47 µM 0.0398922674475144 0.486447628425745 no 1624 0.484089507940273 2315 45595718 SGTC_1997 st073024 93.8 µM 0.0389324922154727 0.486815971479122 no 1625 0.484472105578637 2340 686268 SGTC_2488 5268135 45.7 µM 0.0367455906026945 0.487655303265369 no 1626 0.485343928562938 2301 1270356 YLR208W SEC13 SGTC_2047 4141938 200 µM 0.0364441010784665 0.487771019172185 no 1627 0.485464124971367 2293 3807862 SGTC_1380 2291-0730 164 µM 0.0357685304366573 0.488030316380681 no 1628 0.485733463037987 2296 2999191 SGTC_2174 5790901 200 µM 0.0356604626341658 0.488071795386478 no 1629 0.485776548366554 2305 786020 SGTC_1842 st055362 61.2 µM 0.0351486675144537 0.488268236331975 no 1630 0.485980597150536 2304 676032 SGTC_3199 9111318 49.47 µM 0.0348142800786658 0.488396584903146 no 1631 0.486113916839241 2341 8548020 SGTC_1856 st057054 55.7 µM 0.034780218922717 0.488409658729659 no 1632 0.486127497050188 2345 1266018 SGTC_1287 0971-0001 34.6 µM 0.0326212455322019 0.489238370735962 no 1633 0.486988313680354 2343 4665869 SGTC_2844 9010103 25.97 µM 0.0317162141500062 0.489585776896177 no 1634 0.487349182184911 2298 2480525 SGTC_495 decylubiquinone 155 µM 0.0310643707460063 0.489835999001352 no 1635 0.487609101986769 2246 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1264 0783-0040 158 µM 0.0288930416441511 0.490669532002586 no 1636 0.488474947635096 2336 2855798 SGTC_2353 9059630 146.67 µM 0.0279268419295419 0.491040451483335 no 1637 0.488860250012654 2327 4779114 SGTC_359 0081-0058 15.9 µM 0.0273764391944712 0.491251751963272 no 1638 0.489079745001724 2334 3494159 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0268243213407052 0.491463713346383 no 1639 0.489299927285408 2350 1377 SGTC_3335 9143315 29.6265 µM 0.0268207414847323 0.49146508768267 no 1640 0.489301354927664 2313 4899691 SGTC_1394 3474-0001 65.7 µM 0.0268073665979333 0.491470222413124 no 1641 0.489306688817643 2319 5017666 YIL048W NEO1 SGTC_3306 9127676 59.7925 µM 0.025581231452606 0.491940951804052 no 1642 0.489795678151311 2311 41905287 SGTC_222 nsc-310342 10.666 µM 0.0242214888187066 0.492462987962109 no 1643 0.490337968779435 2359 432556 SGTC_625 k213-0058 121 µM 0.0239424916828051 0.492570102940642 no 1644 0.4904492402625 2325 3655420 SGTC_26 0302-0163 425.158 µM 0.0238153239377821 0.492618926452597 no 1645 0.490499958390802 2352 3100915 SGTC_2011 4012611 177 µM 0.0236167890171311 0.49269515018487 no 1646 0.490579140093598 2349 2049887 SGTC_3131 9127911 49.47 µM 0.0232802055769719 0.492824375646277 no 1647 0.490713380548203 2333 45595681 SGTC_3085 9117376 49.47 µM 0.023212732503347 0.492850280871183 no 1648 0.490740291137854 2265 16480349 SGTC_2332 7982454 138.89 µM 0.023182992598573 0.492861699049233 no 1649 0.490752152451325 2360 2981748 SGTC_2115 tiliquinol 12.7705 µM 0.0231829427251702 0.492861718197363 no 1650 0.490752172342588 2329 71208 A bioactive hydroxyquinoline. SGTC_1556 plumbagin 1.48 µM 0.0231016462740078 0.492892930746593 no 1651 0.490784596250464 2358 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2557 derrustone 83.84 µM 0.0230655882692897 0.492906774688914 no 1652 0.490798977481038 2252 629853 An antioxidant. SGTC_3129 9127257 49.47 µM 0.022715079031386 0.493041348015181 no 1653 0.490938773805839 2323 837894 SGTC_2184 6075246 200 µM 0.0222151953978927 0.49323327300593 no 1654 0.491138148203723 2336 2267320 SGTC_2828 7998861 71.43 µM 0.0215868444642131 0.493474523863313 no 1655 0.491388763842286 2368 2988188 SGTC_1221 2958-7315 257 µM 0.018907247822506 0.494503361587923 no 1656 0.492457548824546 2351 4562705 SGTC_110 0850-0284 111.64 µM 0.0183207720165063 0.494728545531466 no 1657 0.49269147828703 2371 3906265 SGTC_868 0527-0199 213 µM 0.0179276859154329 0.494879476279997 no 1658 0.492848271197193 2282 2849450 SGTC_3240 9133527 49.47 µM 0.0171560927932729 0.495175742052598 no 1659 0.493156044951869 2373 17617455 SGTC_3311 9131146 2.8755 µM 0.0163428043917681 0.495488020285445 no 1660 0.493480454563668 2326 4900406 YPR165W RHO1 SGTC_993 3909-8757 62.7 µM 0.0163036171717449 0.495503067068145 no 1661 0.493496085919981 2359 4288324 YLR208W SEC13 SGTC_2183 6420625 130.508 µM 0.0156294417811289 0.495761932309073 no 1662 0.493765008702176 2374 2897619 SGTC_62 0180-0423 3.232 µM 0.0152601137395593 0.495903745120048 no 1663 0.493912331700112 2364 30102 YGL099W LSG1 SGTC_2698 st077697 67.5 µM 0.0148219434541828 0.496071992315717 no 1664 0.494087116579434 2354 3154499 SGTC_2032 5185112 25.99 µM 0.0142567903052479 0.496288999004238 no 1665 0.494312556232983 2379 5718189 SGTC_2539 epi(13)torulosol 80 µM 0.0141823810039536 0.496317570663293 no 1666 0.494342238248365 2367 6708597 SGTC_59 0330-0160 1.33 µM 0.0134086079870326 0.496614684864316 no 1667 0.494650899639602 2333 4293482 SGTC_329 k048-0121 21.3 µM 0.0133799081804012 0.496625705084281 no 1668 0.494662348178891 2342 6832902 SGTC_1387 3342-1166 1.8 µM 0.0126976073844243 0.496887697305112 no 1669 0.494934523671926 2355 3418228 SGTC_1820 st053765 18.6 µM 0.0122256219740967 0.49706893268858 no 1670 0.495122803986324 2360 3690829 SGTC_192 3455-0609 60.9 µM 0.0117811297467094 0.497239611652141 no 1671 0.49530011795343 2358 3769639 SGTC_2180 6301957 200 µM 0.0116376198218449 0.49729471761881 no 1672 0.495357366205293 2377 845462 SGTC_1983 st071813 46.9 µM 0.0114452166250137 0.497368598054314 no 1673 0.495434118863212 2332 11838595 SGTC_228 caffeine 993.056 µM 0.010629104411219 0.497681975970815 no 1674 0.495759680691414 2381 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2485 5633444 17.78 µM 0.00971478581207321 0.498033065725081 no 1675 0.496124422155559 2381 5724239 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.00629499122796103 0.499346246027712 no 1676 0.497488678430409 2329 61125 An anti-inflammatory. SGTC_928 2764-0428 58.7 µM 0.00489142850866362 0.499885208427413 no 1677 0.498048610137852 2347 662578 SGTC_2265 7929201 200 µM 0.00481162441661517 0.499915852891135 no 1678 0.498080446989632 2398 1265108 SGTC_572 0960-0087 17.7 µM 0.00437335383555578 0.499915852891135 no 1679 0.498255289809462 2394 6796365 SGTC_68 0986-0284 82.829 µM 0.00390053096471937 0.49973429074468 no 1680 0.498443917227903 2368 423278 YIL048W NEO1 SGTC_1852 st056254 31.4 µM 0.00363915204004831 0.499633922273741 no 1681 0.498548191590903 2380 442583 SGTC_2388 9080168 200 µM 0.00236908274624287 0.499146221145789 no 1682 0.49905487361085 2402 15943073 SGTC_3229 9132204 49.47 µM 0.000639120000290885 0.498481925110994 no 1683 0.499745028026992 2402 17682924 SGTC_2253 7938677 135.83 µM 0 0.498236507566399 no 1684 0.5 2405 2301972 SGTC_3169 9102970 49.47 µM 0 0.498236507566399 no 1685 0.5 2405 17027839 SGTC_2252 omeprazole 400 µM -6.16344539321505e-05 0.498212840407282 no 1686 0.499975411410413 2405 4594 A proton pump inhibitor. SGTC_2646 retinol 96.75 µM -0.000196880563906215 0.498160906957164 no 1687 0.499921456019376 2402 445354 A vitamin A analog and teratogen. SGTC_1652 st011932 78 µM -0.00134346472316065 0.497720628933708 no 1688 0.49946403528093 2408 1551076 SGTC_1158 4092-0494 91.8 µM -0.00134811922131763 0.497718841653497 no 1689 0.499462178406503 2416 1148199 SGTC_373 0844-0104 25.9 µM -0.00189020192711741 0.497510687700443 no 1690 0.499245918981815 2408 5375804 SGTC_1379 2144-0755 36.5 µM -0.00277725686262114 0.497170069593781 no 1691 0.498892036238282 2412 5392327 SGTC_3075 9116269 49.47 µM -0.00290051079334668 0.497122741768816 no 1692 0.498842865232262 2413 17015205 YNL244C SUI1 SGTC_982 1491-0518 27.5 µM -0.00365201847516528 0.496834173990056 no 1693 0.498543058660046 2421 3091256 SGTC_3184 9108758 49.47 µM -0.00375399863470774 0.496795015249003 no 1694 0.498502374741595 2410 902885 SGTC_273 hydroxyurea 18.1 mM -0.00468298790227227 0.496438299780667 no 1695 0.498131764955694 2414 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_802 4112-3352 742 µM -0.00592616386134864 0.495960946678414 no 1696 0.497635816513254 2437 704594 SGTC_682 0kpi-0099 17 µM -0.00627336838161343 0.495827628538084 no 1697 0.497497304527711 2426 1714895 YML126C ERG13 SGTC_3093 9117344 49.47 µM -0.00779912059553394 0.495241782303587 no 1698 0.496888632586676 2467 24824913 SGTC_2342 7990637 118.86 µM -0.00785620288133229 0.495219864491477 no 1699 0.496865860747064 2424 2033102 YER133W GLC7 SGTC_2337 9009472 200 µM -0.00835707229398378 0.495027546931256 no 1700 0.496666049329155 2422 5742383 SGTC_3024 9090631 49.47 µM -0.00858489126611946 0.494940072237024 no 1701 0.49657516596993 2421 25236383 SGTC_2974 9094440 9.66 µM -0.00866311919344638 0.49491003544411 no 1702 0.496543958702737 2492 25236134 SGTC_2290 7904846 200 µM -0.00919083895009523 0.49470741024435 no 1703 0.496333437370539 2432 2962154 SGTC_412 gemfibrozil 100 µM -0.00995547041120388 0.494413822000156 no 1704 0.496028407536803 2421 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1688 st021091 57.6 µM -0.0100970939183885 0.494359444501176 no 1705 0.495971910771713 2413 3656366 SGTC_2240 6690706 185.951 µM -0.0103684977130701 0.494255237097609 no 1706 0.495863641991852 2421 805876 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0109096878263778 0.494047444509088 no 1707 0.495647750595304 2431 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_462 ag-879 158 µM -0.0109129430258615 0.494046194664169 no 1708 0.495646452035902 2418 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_137 0438-0332 85.389 µM -0.0115837414525652 0.493788640590576 no 1709 0.49537885911604 2424 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2409 alverine citrate 63.97 µM -0.0119149047361129 0.493661490893434 no 1710 0.49524675319982 2520 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_615 k087-0205 167 µM -0.0128106028335228 0.493317592077202 no 1711 0.494889448676072 2430 9642773 SGTC_440 fluspirilene 35.1 µM -0.0129981831193985 0.493245572182633 no 1712 0.494814621199697 2489 3396 An atypical antipsychotic. SGTC_223 busulfan 5 mM -0.0131672961999975 0.493180642806979 no 1713 0.494747160615216 2449 2478 A DNA alkylator. SGTC_52 0329-0193 875 nM -0.0135542790847527 0.49303206505307 no 1714 0.494592790560623 2448 3739292 SGTC_1277 0873-0036 22 µM -0.0137137895871843 0.492970823058425 no 1715 0.494529160991328 2444 5965735 SGTC_93 0109-0045 59.227 µM -0.0147119496652884 0.492587596224173 no 1716 0.49413099296822 2428 88733 SGTC_2889 9059656 51.95 µM -0.0151830079558353 0.492406743642311 no 1717 0.493943088893931 2448 3949838 SGTC_1399 3562-5772 25 µM -0.0160563038328591 0.492071464847659 no 1718 0.493594736753317 2433 23847490 SGTC_454 lyso-paf C-16 6.67 µM -0.0175252979403252 0.491507496270839 no 1719 0.493008775553002 2453 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1795 st049545 62.3 µM -0.0177356159428379 0.491426753440188 no 1720 0.492924883848793 2435 5291882 SGTC_219 mitoxanthrone 164.414 µM -0.0177717336738821 0.491412887578054 no 1721 0.49291047722942 2468 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1286 0929-0070 131 µM -0.0183885632680475 0.491176083783645 no 1722 0.492664438045783 2459 1420408 SGTC_3349 9149703 23.001 µM -0.020340492584827 0.490426749788709 no 1723 0.491885877024554 2434 4910494 SGTC_1242 0402-0103 60.1 µM -0.0210063310058823 0.490171145995053 no 1724 0.49162030268935 2450 432868 SGTC_891 0929-0073 133 µM -0.0221549156240815 0.489730233875686 no 1725 0.491162190436904 2525 5603632 SGTC_607 4491-0986 66.8 µM -0.0221682670702697 0.489725108671335 no 1726 0.491156865288362 2452 698981 YDR232W HEM1 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0221809152801882 0.489720253419049 no 1727 0.491151820623069 2459 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1187 1391-0724 117 µM -0.0224102992103923 0.489632200365977 no 1728 0.491060332417017 2462 6997986 SGTC_2561 acetosyringone 100 µM -0.0236201361994103 0.489167791636541 no 1729 0.49057780513346 2436 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2817 7995342 71.43 µM -0.0252515402053941 0.488541583316035 no 1730 0.489927163452577 2456 18879975 SGTC_1408 3909-7976 48.8 µM -0.0260036751268367 0.48825288856192 no 1731 0.489627203558061 2467 24152374 SGTC_3102 9121669 49.47 µM -0.0261972284811461 0.488178597245243 no 1732 0.489550013238432 2466 41905072 SGTC_3123 9126162 49.47 µM -0.0273298428785682 0.48774387573172 no 1733 0.489098327289365 2457 25239884 SGTC_1029 k015-0030 64.7 µM -0.0280292108398516 0.487475450661093 no 1734 0.488819426706906 2541 2208316 SGTC_2835 9006588 71.43 µM -0.0281728604789049 0.487420317057301 no 1735 0.488762141415025 2557 2345538 SGTC_2272 7805186 180 µM -0.0283957659644662 0.487334765054697 no 1736 0.488673250556047 2451 2956062 YPR165W RHO1 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0284805447592762 0.487302226772378 no 1737 0.488639442383909 2460 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1743 st037606 46.3785 µM -0.0291531346571782 0.487044088347672 no 1738 0.488371229227918 2484 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1215 3852-0577 11.2 µM -0.0293776566848183 0.486957918523359 no 1739 0.488281696247469 2515 2884876 SGTC_2924 9010168 62.78 µM -0.0296324980681825 0.486860113101929 no 1740 0.488180073488578 2490 2993929 SGTC_2744 captopril 92.04 µM -0.0297862019458153 0.486801123564778 no 1741 0.488118781568677 2472 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2224 6650123 117.647 µM -0.0301823132378817 0.486649102567906 no 1742 0.487960827048477 2457 2908370 SGTC_299 1273-0059 1.44 µM -0.0304986278466739 0.486527707617346 no 1743 0.4878346938466 2473 2848077 SGTC_365 0121-0052 13.6 µM -0.0306281614122507 0.486477995695766 no 1744 0.487783041560976 2479 3101739 SGTC_427 1354-0053 47.3 µM -0.0311602798586573 0.486273783422958 no 1745 0.487570858300652 2639 6813657 SGTC_3099 9120367 49.47 µM -0.0316596474384923 0.486082143295545 no 1746 0.487371737710667 2470 24824940 SGTC_2606 farnesol 9.78 µM -0.0321226623178892 0.485904456956866 no 1747 0.487187115409009 2475 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2804 7954240 19.48 µM -0.0321773035483128 0.485883488051883 no 1748 0.487165327974832 2491 828705 SGTC_1653 st012112 65 µM -0.0340167814728198 0.485177600337136 no 1749 0.486431884382532 2489 720429 SGTC_2167 5876490 200 µM -0.0357673896748882 0.484505858902134 no 1750 0.485733917845068 2587 686534 SGTC_1443 4112-3303 14 µM -0.036001965905694 0.484415850870312 no 1751 0.485640395702929 2475 704433 SGTC_3232 9132874 49.47 µM -0.0368362413136705 0.484095741835873 no 1752 0.485307788628865 2478 3784940 SGTC_574 1315-0397 40 µM -0.0370294241530469 0.484021619599355 no 1753 0.485230772370827 2482 6794277 SGTC_3040 9091894 49.47 µM -0.0384673741974419 0.48346991071951 no 1754 0.484657521920114 2501 25236966 SGTC_1375 2910-0797 186 µM -0.0391701017424185 0.48320030151584 no 1755 0.484377385344236 2493 742508 SGTC_35 0133-0054 64.071 µM -0.0393548896324273 0.483129406866278 no 1756 0.484303722441284 2513 99677 SGTC_1492 4158-0558 28.5 µM -0.0400340434764781 0.482868851243497 no 1757 0.484032992635033 2518 3967268 SGTC_70 0141-0289 43.283 µM -0.0400976873909455 0.482844434792867 no 1758 0.484007622757637 2576 352408 SGTC_523 1934-0222 13.7 µM -0.0406449463151611 0.482634486190275 no 1759 0.483789475882219 2489 1361595 SGTC_1103 duloxetine 36.1 µM -0.040682859321375 0.482619941547728 no 1760 0.483774363280975 2551 60835 A selective serotonin reuptake inhibitor. SGTC_1033 k072-0102 21.3 µM -0.0412807198424839 0.482390586188877 no 1761 0.483536051651952 2471 5965931 SGTC_1354 1498-1681 81 µM -0.041654674315323 0.482247130163673 no 1762 0.483386993615625 2518 5754243 SGTC_1903 st060211 78.3 µM -0.0417093351036533 0.482226161441112 no 1763 0.483365206051049 2475 688960 SGTC_1184 1269-1718 139 µM -0.042210800766533 0.482033793770409 no 1764 0.483165326234452 2518 5403821 SGTC_2212 7123476 200 µM -0.0433966946239397 0.481578888739663 no 1765 0.482692656264429 2482 1085715 SGTC_1552 6-methylflavone 10.6 µM -0.0439265518574452 0.481375644943316 no 1766 0.482481475201012 2495 689013 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0442531275205662 0.481250378744195 no 1767 0.48235131693156 2472 97141 SGTC_2065 5221596 34.26 µM -0.0447891116998512 0.481044792730755 no 1768 0.48213770199461 2539 788581 SGTC_1739 st037196 92.5 µM -0.0449294366566998 0.480990969494066 no 1769 0.482081776735415 2492 612214 SGTC_2967 9089538 49.85 µM -0.0449672076547152 0.480976482056394 no 1770 0.482066723501431 2497 728216 SGTC_3345 9148410 3.559 µM -0.0474453166814773 0.480026034772581 no 1771 0.48107915608797 2505 4903596 SGTC_1764 st044502 93.5 µM -0.0483186882093212 0.479691090984586 no 1772 0.480731130455596 2544 8407 SGTC_596 1155-0152 116 µM -0.0491515893410041 0.479371681217674 no 1773 0.480399245354908 2496 280313 SGTC_2645 abamectin 100 µM -0.0516372344911431 0.478418539189319 no 1774 0.479408875034468 2516 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_892 0929-0076 29 µM -0.0520432228504966 0.478262871039299 no 1775 0.479247126601889 2496 5751038 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0533755322791939 0.477752046949359 no 1776 0.47871634991449 2488 66535 A nucleotide analog. SGTC_2371 9071574 200 µM -0.0545363187367994 0.477307016675784 no 1777 0.478253936732398 2486 45596039 SGTC_2695 st077686 51.995 µM -0.0546374112651714 0.477268260460482 no 1778 0.478213666690173 2526 2876092 SGTC_1112 tnp00069 1.16933 µM -0.0548421932849595 0.477189753081836 no 1779 0.478132092791844 2619 145826 SGTC_3198 9112019 49.47 µM -0.055357724485989 0.476992117570683 no 1780 0.477926737567672 2525 45595555 SGTC_1713 st033146 12.748 µM -0.055689955403913 0.476864755574213 no 1781 0.477794400755932 2516 674619 SGTC_2567 aureobasidin a 60 nM -0.0565024411191723 0.476553296042227 no 1782 0.477470775450946 2659 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1175 0741-0056 27.6 µM -0.0572481482018116 0.476267448135989 no 1783 0.47717376215164 2547 765927 SGTC_2347 9049783 174.81 µM -0.0573564160381754 0.47622594741733 no 1784 0.477130640388541 2558 6467988 YPL169C MEX67 SGTC_2352 9027995 87.8 µM -0.0575036803485587 0.476169499167383 no 1785 0.47707198723381 2553 2997347 SGTC_1725 st036284 20.55 µM -0.0580315358663133 0.475967169490216 no 1786 0.476861754428668 2516 707914 SGTC_2018 5133068 143 µM -0.0598760810045152 0.475260195051724 no 1787 0.476127165150156 2510 785362 SGTC_1872 amphotericin b 148 nM -0.0601247672425506 0.475164884880062 no 1788 0.476028132118016 2540 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_263 alizarin 107.927 µM -0.0601745059323759 0.475145822463363 no 1789 0.476008325114762 2493 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0623314982417897 0.474319207715814 no 1790 0.475149422633625 2561 75037 A free radical scavenger. SGTC_2270 7924575 90.91 µM -0.0623957289361893 0.474294594544476 no 1791 0.475123848074867 2570 1262135 SGTC_1847 st056231 15 µM -0.0627232804169378 0.474169078501873 no 1792 0.474993429399874 2514 5393180 SGTC_2840 9008771 71.43 µM -0.0629496718017374 0.474082327985468 no 1793 0.474903290433897 2626 2992978 SGTC_2478 5763493 32.33 µM -0.0629827920551873 0.474069636796774 no 1794 0.474890103531748 2533 1365576 YLR208W SEC13 SGTC_688 0527-0193 473 µM -0.0631430880960506 0.474008214109298 no 1795 0.474826281697618 2560 4007154 SGTC_1825 st052143 62.6 µM -0.0631553990713216 0.474003496780722 no 1796 0.474821380112157 2543 674173 SGTC_2782 7736369 71.43 µM -0.0635333941297 0.47385865813307 no 1797 0.474670884139055 2534 2950836 YOL077C BRX1 SGTC_14 0354-0009 295 µM -0.0636945578569004 0.473796905104749 no 1798 0.474606719075311 2510 1713507 SGTC_406 estrone 100 µM -0.0656901459546821 0.473032309199915 no 1799 0.473812258928718 2538 5870 A steroid. SGTC_2805 7950783 58.44 µM -0.0660750972459601 0.472884829094147 no 1800 0.473659018516345 2587 1178958 YDL195W SEC31 SGTC_2207 7258803 200 µM -0.0667520373166464 0.4726254931202 no 1801 0.473389553434925 2520 3666799 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.0674616470518965 0.472353653845662 no 1802 0.473107096828835 2520 688662 SGTC_798 1287-0182 476 µM -0.0682634925115825 0.472046496155795 no 1803 0.472787942533086 2530 1649755 SGTC_2182 6325192 200 µM -0.0692056884373083 0.471685596588958 no 1804 0.472412947624018 2526 736248 SGTC_1438 4092-1045 4 µM -0.0704735758097312 0.471199980625763 no 1805 0.471908365847384 2531 1351342 SGTC_1089 terbinafine 2.25 µM -0.0705302377725796 0.471178279413384 no 1806 0.471885817103888 2591 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2591 skatole 100 µM -0.0705822339878682 0.47115836523132 no 1807 0.471865125183421 2591 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_962 1254-0300 21.5 µM -0.0709340328830028 0.471023630644087 no 1808 0.471725128631015 2520 7340576 SGTC_3001 9076041 71.4286 µM -0.0710443319722541 0.470981388151396 no 1809 0.471681236396966 2542 16004211 SGTC_2754 granisetron 64.02 µM -0.0711328877932206 0.470947473160946 no 1810 0.471645996891425 2579 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2232 chlorophetanol 41.5365 µM -0.0721375639381933 0.470562718442904 no 1811 0.471246216191364 2551 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_743 1275-0778 158 µM -0.0722867286307748 0.470505596081105 no 1812 0.471186863042012 2600 2849257 YMR203W TOM40 SGTC_2743 auranofin 4.32 µM -0.0739360585898718 0.469874028733619 no 1813 0.470530631875306 2564 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_974 1326-0144 138 µM -0.0742311961279154 0.469761021556197 no 1814 0.470413211699297 2554 5411856 SGTC_487 nimodipine 119 µM -0.0745666937449117 0.469632563597913 no 1815 0.470279737430766 2521 4497 L-type voltage-gated calcium channels inhibitor SGTC_647 0140-0236 81 µM -0.0746763126712453 0.469590592528275 no 1816 0.470236127393907 2577 990837 SGTC_2956 9076196 2.52 µM -0.0770639439496301 0.46867649707796 no 1817 0.469286338114349 2550 16423868 SGTC_384 k007-0144 5.16 µM -0.0773428908329311 0.468569714015553 no 1818 0.469175385561179 2608 6824886 SGTC_1479 0549-0158 134 µM -0.0778973260929392 0.46835747855522 no 1819 0.468954863209127 2566 5440202 SGTC_3065 9113888 49.47 µM -0.0785596625072917 0.468103950785112 no 1820 0.46869143649472 2650 16648368 SGTC_1410 3909-8106 77.9 µM -0.0786682035999153 0.468062404879902 no 1821 0.468648268462508 2587 1039210 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0799703232659617 0.467564024206042 no 1822 0.468130429478752 2544 15053 SGTC_642 0335-0876 158 µM -0.0801847967738273 0.467481940253748 no 1823 0.468045140820606 2554 6812350 SGTC_1427 4048-4900 550 nM -0.0802039707009032 0.467474602017428 no 1824 0.468037516087735 2615 24132586 SGTC_1152 3909-8331 15.9 µM -0.0808074704920433 0.467243636524493 no 1825 0.467797533454153 2560 16001939 SGTC_1788 fluconazole 20 µM -0.0819774293973478 0.466795912863711 no 1826 0.467332330882732 2653 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2875 9039966 71.43 µM -0.0827874547219123 0.466485954328935 no 1827 0.467010272282162 2651 6463691 SGTC_2524 avocatin b 10.57 µM -0.0828159404783526 0.466475054540646 no 1828 0.466998946999904 2606 6710748 SGTC_71 0417-1750 47.813 µM -0.0868822371515537 0.464919388921263 no 1829 0.465382559411253 2562 6811472 SGTC_2764 methyldopa 94.69 µM -0.0873399618256253 0.464744307786073 no 1830 0.465200645212346 2613 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2533 agelasine 13.65 µM -0.0878049085863167 0.464566471168038 no 1831 0.465015868174381 2612 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_226 1,3-diallylurea 8.28947 mM -0.0879065055238632 0.464527612486235 no 1832 0.464975492982009 2656 74537 YKL182W FAS1 SGTC_1590 st077108 57.8 µM -0.0886873149809693 0.464228980687032 no 1833 0.464665206993272 2536 5489485 SGTC_2585 alliin 100 µM -0.0895576987919367 0.463896113647004 no 1834 0.464319350371491 2640 87310 A garlic compound which reacts with lipids. SGTC_2652 actinonin 100 µM -0.0905440058067417 0.463518943831828 no 1835 0.463927462981234 2556 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_779 1360-0071 233 µM -0.0912454533751442 0.463250725936609 no 1836 0.46364877949632 2733 7566 SGTC_413 propylparaben 100 µM -0.0914081325212191 0.463188523443721 no 1837 0.46358414999353 2569 7175 A pharmaceutical preservative. SGTC_3122 9126309 49.47 µM -0.0917723662070535 0.463049257209879 no 1838 0.463439449979569 2548 17591206 SGTC_758 0868-0029 16 µM -0.0934951973015846 0.462390587377629 no 1839 0.462755082491044 2593 762687 SGTC_692 k241-0027 77.8 µM -0.0945477434931147 0.461988230349067 no 1840 0.462337029225211 2661 3600480 SGTC_1972 st070201 17.4 µM -0.0951895078114813 0.461742922045989 no 1841 0.462082151848804 2618 2829099 SGTC_1512 0259-0544 12.2 µM -0.0952168195673121 0.461732482709443 no 1842 0.462071305300816 2585 18476 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0952932901845941 0.461703253586151 no 1843 0.462040936029566 2742 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3022 9087993 49.47 µM -0.097636937580798 0.460807549684865 no 1844 0.461110296336121 2569 17173644 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0977408503099017 0.460767840499904 no 1845 0.46106903848974 2586 16623 A steroid. SGTC_786 4544-0069 423 µM -0.0980351221076917 0.460655389670787 no 1846 0.460952202137507 2703 748821 YLR208W SEC13 SGTC_331 k048-0133 24.5 µM -0.0984084294175994 0.460512741329299 no 1847 0.460803990732018 2569 6813582 SGTC_635 k038-0028 24.7 µM -0.0996088872552764 0.460054056426966 no 1848 0.460327418955496 2609 4035102 SGTC_504 lovastatin 124 µM -0.100743786326109 0.459620469850992 no 1849 0.459876925853059 2589 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_583 1488-1091 88.9 µM -0.1019728769155 0.459150951718641 no 1850 0.459389101960172 2562 4303273 SGTC_2960 9079389 5.97 µM -0.103048558635756 0.458740083191119 no 1851 0.458962215919726 2643 16457355 SGTC_3179 9107801 49.47 µM -0.103396620652795 0.458607146471632 no 1852 0.45882409705071 2613 4818259 SGTC_1498 4478-3555 97.6 µM -0.103808618254951 0.45844979656218 no 1853 0.45866061352293 2590 3437919 SGTC_2638 epoxomicin 18 µM -0.104016616346853 0.458370360510947 no 1854 0.458578081080707 2692 9915668 A protesome inhibitor. SGTC_1569 carminic acid 40.6 µM -0.105663619164813 0.457741416583915 no 1855 0.457924623205303 2626 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1132 3456-3614 2.5 µM -0.105822390302683 0.457680791930609 no 1856 0.457861635821132 2797 3125502 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.106044175558083 0.457596107820933 no 1857 0.457773651367971 2696 6708760 SGTC_2626 ethyl orsellinate 100 µM -0.106411811850766 0.457455737753511 no 1858 0.457627810893716 2607 75653 A natural product. SGTC_991 3996-0057 64.7 µM -0.106670829152491 0.45735684353212 no 1859 0.457525062748783 2673 715343 SGTC_2424 5537928 59.2 µM -0.10756558008724 0.457015243088251 no 1860 0.457170150819102 2621 5382802 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.108295051922566 0.456736766837684 no 1861 0.45688082376384 2668 551469 SGTC_2035 5154463 94.595 µM -0.108626638247169 0.456610190601966 no 1862 0.456749315753279 2676 2769623 SGTC_585 0kpi-0023 191 µM -0.108739518546623 0.456567101881229 no 1863 0.456704548208906 2660 64601 SGTC_1708 st033234 31.827 µM -0.111065729944596 0.455679253813109 no 1864 0.455782112054357 2696 674664 SGTC_2946 9065502 71.43 µM -0.111119011438496 0.45565892037292 no 1865 0.455760986576915 2583 16489101 SGTC_653 0203-0016 55.2 µM -0.111152158605316 0.455646270712365 no 1866 0.45574784418335 2681 295302 SGTC_48 0382-0018 55 µM -0.11215975963861 0.455261770344568 no 1867 0.455348367472248 2754 762596 SGTC_2292 7671323 168.05 µM -0.112439667891658 0.45515496482913 no 1868 0.455237402150867 2708 937504 SGTC_1703 st026983 48.3 µM -0.11334435335919 0.454809783219038 no 1869 0.45487877744157 2627 1104023 SGTC_44 0929-0055 61.211 µM -0.113344616552946 0.454809682802742 no 1870 0.454878673114751 2615 1379590 SGTC_308 4092-1169 104 µM -0.113483174488005 0.454756819203771 no 1871 0.454823750859081 2625 2268590 YDL196W YDL196W SGTC_103 0844-0104 51.839 µM -0.113501148697285 0.454749961615584 no 1872 0.454816626219469 2732 5375804 SGTC_2024 5144227 134 µM -0.113740123239014 0.454658788428544 no 1873 0.454721902573138 2719 3475211 SGTC_694 1315-0438 43.2 µM -0.11540762844533 0.454022671242667 no 1874 0.454061016370284 2664 6793154 SGTC_1034 k072-0165 12.7 µM -0.116318718911003 0.453675159638849 no 1875 0.453699975382593 2669 5835461 SGTC_795 0685-0265 78 µM -0.117015126818202 0.453409556977129 no 1876 0.453424033182554 2607 302754 SGTC_2757 clomiphene 4.22 µM -0.117932219516197 0.453059819263505 no 1877 0.453060681947633 2718 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_592 k241-0073 46.5 µM -0.118635987710232 0.452791458551229 no 1878 0.452781876306037 2644 4230158 SGTC_1747 st037496 66.6 µM -0.119457020905588 0.452478409636035 no 1879 0.452456644250206 2627 723305 SGTC_261 5-fluorouridine 15.376 µM -0.119665418247754 0.452398955224834 no 1880 0.452374097848622 2679 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1177 0983-0204 23.6 µM -0.120358813469218 0.452134602306212 no 1881 0.45209945812719 2697 766818 SGTC_3257 9139206 32.98 µM -0.120606509782009 0.452040174657009 no 1882 0.452001356213002 2715 4910041 SGTC_1773 st048542 73.5835 µM -0.12080227335314 0.451965546907201 no 1883 0.451923824709427 2611 3237138 SGTC_1520 flindersine 88 µM -0.120905756125344 0.451926098545162 no 1884 0.451882841446313 2904 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3265 9137266 49.47 µM -0.121738913262948 0.451608510499968 no 1885 0.451552897048493 2592 17224265 SGTC_53 0973-0023 39.979 µM -0.12199081573277 0.451512494829855 no 1886 0.451453145963815 2608 674768 SGTC_3064 1327-0027 10 µM -0.122287372238016 0.45139946237026 no 1887 0.451335716216626 2618 16000455 YPR107C YTH1 SGTC_631 k072-0230 41.5 µM -0.123232038361644 0.45103942935527 no 1888 0.450961677985563 2721 5773147 SGTC_3227 9130768 49.47 µM -0.123441140859367 0.450959741233125 no 1889 0.450878890239228 2638 17720899 SGTC_1144 3486-0183 12.5 µM -0.123945014396371 0.45076772517777 no 1890 0.450679405690051 2651 6744069 SGTC_2448 5185112 27.17 µM -0.126344843318953 0.449853357594264 no 1891 0.449729480403738 2751 5718189 SGTC_202 3594-0513 34.79 µM -0.126796615990529 0.449681255661459 no 1892 0.449550687084437 2601 708429 SGTC_2168 5727979 200 µM -0.127245203823647 0.449510376351099 no 1893 0.449373164328601 2607 695210 SGTC_105 0111-0055 734.78 µM -0.128110331214941 0.44918085225722 no 1894 0.449030830146979 2719 5179370 SGTC_784 4579-0127 173 µM -0.129290048377155 0.448731558510217 no 1895 0.448564072793924 2842 1948547 SGTC_2827 7993847 71.43 µM -0.129330355158765 0.448716208883054 no 1896 0.448548126592661 2710 2985692 SGTC_658 3253-0951 102 µM -0.13063224413108 0.44822046498019 no 1897 0.4480331170795 2681 1184878 SGTC_1673 st016611 27.3 µM -0.134539822970383 0.446732993820698 no 1898 0.446487861572875 2849 5226799 SGTC_1269 0831-0796 3.05 µM -0.135595396195003 0.446331303661162 no 1899 0.446070572571395 2737 927758 SGTC_1974 st069448 26.9 µM -0.137447706113103 0.44562655491309 no 1900 0.445338462405037 2736 6323587 YNR016C ACC1 SGTC_49 0717-0965 32.132 µM -0.13844186870026 0.445248376357207 no 1901 0.444945604569 2929 5889349 YGL099W LSG1 SGTC_1658 st012944 20 µM -0.139572969276787 0.44481816731755 no 1902 0.444498699462445 2709 24207260 SGTC_1483 3453-0561 55.9 µM -0.140222493238765 0.444571153129846 no 1903 0.444242100222451 2751 4546991 SGTC_1301 naphtanilide LB 4.81 µM -0.14090912227138 0.444310051277597 no 1904 0.443970867762462 2746 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1671 st016596 74.5 µM -0.142528906172412 0.443694198065663 no 1905 0.443331124307047 2697 2829167 SGTC_729 4092-0585 94.1 µM -0.142574542718383 0.443676848692774 no 1906 0.443313102008274 2646 2169061 SGTC_2785 7756463 72.73 µM -0.14525540959809 0.442657870100853 no 1907 0.442254609622502 2678 2201551 SGTC_442 cape 100 µM -0.145725662517532 0.442479169184253 no 1908 0.442068980932869 2723 5281787 SGTC_2601 securinine 100 µM -0.147056450296321 0.441973519762981 no 1909 0.44154373185473 2700 442872 A GABA receptor antagonist. SGTC_1761 st044296 37 µM -0.147227995796824 0.441908345770897 no 1910 0.441476031962424 2646 1826700 SGTC_2471 5466956 24.79 µM -0.147555530473986 0.441783912353021 no 1911 0.441346776182616 2706 724419 SGTC_1790 st045711 43.5 µM -0.1478366205017 0.441677128262298 no 1912 0.441235853944359 2700 585119 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.14923233976885 0.441146967424583 no 1913 0.440685151130096 2666 4174840 SGTC_929 2805-0021 398 µM -0.149433355639662 0.441070620661059 no 1914 0.440605846605822 2776 3098024 SGTC_2091 4-phenylthiadiazole 200 µM -0.15060251202801 0.440626613121859 no 1915 0.440144639842454 2702 270010 SGTC_3212 9128307 49.47 µM -0.151205330107565 0.440397711564098 no 1916 0.439906872911006 2698 27243542 SGTC_1061 3448-9325 110 µM -0.152248069357076 0.440001810586498 no 1917 0.439495640985859 2636 723482 SGTC_2511 berberine 10.47 µM -0.152911433628938 0.439749979615479 no 1918 0.439234059609028 2697 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1610 st001799 48.1 µM -0.153123909271948 0.439669323279566 no 1919 0.439150280672506 2670 621897 SGTC_2600 tangeritin 87.95 µM -0.154131772143827 0.439286769939808 no 1920 0.43875291852774 2697 68077 A bioactive flavone. SGTC_2520 obtusaquinone 4.71 µM -0.154309447945411 0.439219335610409 no 1921 0.438682874079356 2835 5967872 SGTC_2596 sinensetin 100 µM -0.154933270242604 0.438982586690159 no 1922 0.438436962234787 2741 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2795 7780010 54.55 µM -0.155497148682425 0.438768606046323 no 1923 0.438214700811981 2801 953673 SGTC_408 cantharidin 100 µM -0.15645423924924 0.438405450224795 no 1924 0.437837493383561 2738 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2059 5238311 157 µM -0.15647821375505 0.438396354068515 no 1925 0.437828045302727 2688 703021 SGTC_2163 5671233 125 µM -0.156674820443429 0.438321760842966 no 1926 0.437750566174278 2762 701023 SGTC_3291 9121177 71.43 µM -0.157720550545145 0.437925044280593 no 1927 0.43733850309257 2716 17015612 SGTC_2093 5331342 194.4 µM -0.157945176828594 0.437839836376879 no 1928 0.437249999431681 2796 33839 SGTC_2079 5212404 121 µM -0.159881816400533 0.437105327257826 no 1929 0.436487086329252 2737 758462 SGTC_2009 4012297 12.05 µM -0.159909398308361 0.437094867829492 no 1930 0.436476222507012 2800 45595307 SGTC_3160 9100216 49.47 µM -0.161142405049807 0.436627340205088 no 1931 0.435990621121376 2649 17191039 SGTC_3197 9113331 49.47 µM -0.16199225422714 0.43630514854914 no 1932 0.435655976769469 2865 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_180 1486-1293 102.781 µM -0.163378435046565 0.43577971560619 no 1933 0.435110240541118 2725 4140536 SGTC_2046 4110841 106 µM -0.163629510854661 0.435684557217684 no 1934 0.435011405757127 2769 44119630 YMR134W ERG29 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.164147164947817 0.435488376719957 no 1935 0.434807646536105 2679 803109 SGTC_3104 9120930 49.47 µM -0.165260315182245 0.435066568988614 no 1936 0.434369546586734 2764 17014836 SGTC_1100 amiodarone 5.07 µM -0.165657667980423 0.434916017350424 no 1937 0.434213180859634 2796 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_816 0325-0417 81.3 µM -0.165668699842236 0.434911837660677 no 1938 0.434208839763264 2759 68101 SGTC_2691 st077356 60.2 µM -0.165687788544238 0.434904605457821 no 1939 0.434201328276118 2860 2839272 SGTC_2568 diosmetin 100 µM -0.165766569258059 0.434874757765487 no 1940 0.434170327974438 2718 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_469 w7 172 µM -0.166089863544023 0.434752274970058 no 1941 0.434043115541857 2703 45115570 A P450 inhibitor. SGTC_1718 roemerine 11.9335 µM -0.167199032277171 0.434332104606544 no 1942 0.433606722916221 2797 235224 An aporphine alkaloid with mutagenic activity. SGTC_1971 st069429 63.5 µM -0.167373176984391 0.434266142608193 no 1943 0.433538214558425 2812 1246522 YGL099W LSG1 SGTC_3048 9093155 49.47 µM -0.168010369431252 0.434024804419067 no 1944 0.433287560707016 2708 25236002 SGTC_2254 7938975 95.19 µM -0.168309523375167 0.433911507612126 no 1945 0.43316989108516 2893 2969277 SGTC_870 0573-2213 57.6 µM -0.168838811916433 0.433711066594203 no 1946 0.432961714526315 2687 3916321 SGTC_2309 7664088 163.95 µM -0.169576339654819 0.433431794045708 no 1947 0.432671665622733 2778 704922 SGTC_1313 1220-0047 237 µM -0.169943939040297 0.433292611117171 no 1948 0.432527112665329 2752 3528706 SGTC_1603 st002045 67.8 µM -0.170325761563957 0.433148051688954 no 1949 0.432376976232912 2756 5887985 SGTC_2746 daunorubicin 9.88 µM -0.171873320891563 0.432562231762563 no 1950 0.431768560642723 2680 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3136 9095672 49.47 µM -0.174695167802102 0.431494419780382 no 1951 0.430659582461721 2643 17217380 SGTC_1320 1313-0481 95.3 µM -0.174840022160438 0.431439619039588 no 1952 0.430602669766992 2789 6813365 YLR208W SEC13 SGTC_32 0928-0142 34.1 µM -0.175886809801912 0.431043641674642 no 1953 0.430191434028397 2724 2244242 SGTC_730 1436-0052 41.2 µM -0.176094352231793 0.430965141034511 no 1954 0.430109908930469 2711 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3350 9150499 3.57 µM -0.176493450713374 0.430814194093292 no 1955 0.42995314674763 2704 4910996 YPR165W RHO1 SGTC_1445 4239-0156 97.7 µM -0.176660216664562 0.430751122904034 no 1956 0.429887645897863 2894 4008346 SGTC_463 ikarugamyin 104 µM -0.177053445202142 0.430602410143716 no 1957 0.429733204726702 2701 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1346 1488-2224 62.4 µM -0.177726367860067 0.430347944369789 no 1958 0.429468938174625 2722 3722427 SGTC_1686 st019653 115.5 µM -0.1792188925729 0.42978364935766 no 1959 0.428882914880293 2765 97252 SGTC_556 4058-0063 51.5 µM -0.181781762077164 0.428815012658857 no 1960 0.427876998900793 2728 6615692 SGTC_181 1447-1644 8.07 µM -0.182389648935058 0.428585324448012 no 1961 0.427638474258853 2796 534600 SGTC_3313 9133968 57.047 µM -0.182977220345786 0.428363335354142 no 1962 0.427407946191323 2701 1494643 SGTC_1563 conessine 56.1 µM -0.183967280040567 0.427989334333015 no 1963 0.427019561767138 2837 441082 An anti-amoebic, histamine inhibitor. SGTC_2859 9028643 45.46 µM -0.184818070493182 0.427667994769257 no 1964 0.426685866911363 2837 17151580 SGTC_478 N-arachidonylglycine 10 µM -0.185174050987119 0.427533556829603 no 1965 0.426546260707797 2722 5283389 SGTC_627 1391-0720 175 µM -0.185356717889901 0.427464574961108 no 1966 0.426474627115866 2824 997839 SGTC_1143 3454-2408 5.08 µM -0.188014141867725 0.426461283909709 no 1967 0.425432782634448 2713 X1143 SGTC_3121 9125696 49.47 µM -0.188182444860422 0.426397758291259 no 1968 0.425366816805507 2695 1235365 SGTC_1057 3448-5381 134 µM -0.188840058749713 0.426149561602978 no 1969 0.425109087155305 2875 5497911 SGTC_1814 st052110 31.539 µM -0.189268337175021 0.425987936445398 no 1970 0.424941255030107 2843 674163 SGTC_2064 5220758 200 µM -0.189272131424807 0.425986504614127 no 1971 0.42493976821464 2880 788518 SGTC_2903 5923464 63.88 µM -0.190432900607611 0.425548512506679 no 1972 0.424484959202751 2823 2876576 SGTC_366 0181-0206 4.31 µM -0.192570404461029 0.424742210579181 no 1973 0.423647712439681 2868 274874 SGTC_691 1548-0686 185 µM -0.192976215531906 0.424589167359644 no 1974 0.423488797610322 2778 46495133 SGTC_1663 st014140 55.4 µM -0.193043428054111 0.424563820649131 no 1975 0.423462478517373 2754 4207120 SGTC_985 1493-0307 8.71 µM -0.193120279813753 0.424534839239897 no 1976 0.423432385308356 2856 3278274 SGTC_3062 9077494 49.47 µM -0.193803331437325 0.424277272989919 no 1977 0.423164939180934 2864 16459633 SGTC_2685 mycophenolic acid 18.85 µM -0.193906585777185 0.424238340481388 no 1978 0.423124513435009 2808 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_390 dec-rvkr-cmk 16.7 µM -0.195755720412713 0.42354124155727 no 1979 0.422400684718722 2798 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2625 euphol 100 µM -0.19631682073014 0.423329761484066 no 1980 0.422181098258108 2882 6708538 A triterpene alcohol. SGTC_569 4130-2812 160 µM -0.197963067592072 0.422709414722475 no 1981 0.42153697981547 2739 743552 SGTC_509 pifithrin 175 µM -0.198029433651618 0.422684410348734 no 1982 0.421511017502551 2766 4817 A p53 inhibitor. SGTC_1675 st018485 24.5 µM -0.198967470829801 0.422331024625971 no 1983 0.421144095170042 2839 3323024 SGTC_1419 3993-2473 62.6 µM -0.199996677950927 0.421943364480041 no 1984 0.420741589624348 2777 704026 SGTC_2318 6029776 164 µM -0.20109813643098 0.42152857398504 no 1985 0.420310919571394 2922 818325 SGTC_2856 9022925 19.48 µM -0.201775427230603 0.421273561006044 no 1986 0.420046146325942 2908 4944862 SGTC_975 1335-0046 28.5 µM -0.202226275992526 0.421103826098018 no 1987 0.419869916102056 2805 16486740 SGTC_2934 9036370 36.88 µM -0.202340553174109 0.421060805513418 no 1988 0.419825249364827 2872 6462800 SGTC_309 k408-0051 1.48 µM -0.2034599854052 0.420639435960966 no 1989 0.419387759273861 2800 3640463 SGTC_16 erodoxin 22.806 µM -0.207476752590007 0.419128221731643 no 1990 0.417818773206444 2808 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_370 0180-0345 38.7 µM -0.207873308734631 0.418979091110709 no 1991 0.417663945235922 2701 3989527 SGTC_1018 4259-0013 28.1 µM -0.2101992085739 0.418104638188277 no 1992 0.416756098616212 2923 6801262 SGTC_2293 7624732 200 µM -0.211125053590698 0.417756666824249 no 1993 0.416394845444903 2746 894453 SGTC_2995 9067767 71.4286 µM -0.211445479176204 0.417636252441809 no 1994 0.416269835811982 2870 11673567 SGTC_2871 9038510 12.99 µM -0.214089700319616 0.416642862769002 no 1995 0.415238553776143 2838 4945164 SGTC_1617 st002906 78 µM -0.216748497996173 0.415644533399721 no 1996 0.414202175186513 2772 5150859 SGTC_1753 st043925 64 µM -0.217127045264489 0.415502440008037 no 1997 0.414054668809169 2889 670181 SGTC_275 trichlorophene 5.69 µM -0.218687753810469 0.414916721539093 no 1998 0.413446644571351 2882 62616 SGTC_655 k060-0012 42 µM -0.219166966382448 0.414736915685369 no 1999 0.413259993462716 2817 5994525 SGTC_3148 9097893 49.47 µM -0.219487706613717 0.414616580381529 no 2000 0.413135077555382 2820 17174100 SGTC_3332 9141069 11.198 µM -0.220985159054676 0.414054872456077 no 2001 0.412551994344327 2781 17332883 SGTC_1561 5-methoxyflavone 52.9 µM -0.221265476456866 0.413949742365682 no 2002 0.412442864784242 2796 94525 SGTC_3314 9135860 59.4275 µM -0.221605246677147 0.413822323389377 no 2003 0.412310598893682 2843 25252478 SGTC_165 k038-0023 64.381 µM -0.224034103278784 0.412911730404193 no 2004 0.411365383510054 2821 46368543 SGTC_762 1165-0429 115 µM -0.224983647068315 0.412555867791377 no 2005 0.410995997955696 2957 5967793 SGTC_1672 st016598 6.51 µM -0.225160378417974 0.41248964171913 no 2006 0.410927255737442 2854 4665860 YNL267W PIK1 SGTC_315 k915-0449 187 µM -0.228685266493831 0.411169292481691 no 2007 0.409556773499629 2839 20970215 YNL149C PGA2 SGTC_706 4262-0057 46.9 µM -0.230604139979291 0.410450944416549 no 2008 0.408811175527852 2823 883298 SGTC_1752 st044819 83.042 µM -0.230732775973722 0.410402799054944 no 2009 0.408761204461522 2847 441209 YML126C ERG13 SGTC_3094 9117742 49.47 µM -0.231644346622519 0.410061658794016 no 2010 0.408407130274874 2777 17149698 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.231660978636995 0.410055435168692 no 2011 0.408400670726465 2776 88881 An O-methylated flavonoid and antioxidant. SGTC_1157 4092-0394 27.6 µM -0.232282496991423 0.409822882039945 no 2012 0.408159303037548 2989 3659885 SGTC_260 nsc-65238 3.989 µM -0.232988799025538 0.409558643962563 no 2013 0.407885051767223 2932 3246252 SGTC_1165 k072-0275 30.3 µM -0.233556712427868 0.409346208914345 no 2014 0.407664568388696 2858 6153523 YGL055W OLE1 SGTC_2730 imipramine 71.33 µM -0.234604428686003 0.408954367552704 no 2015 0.40725788594309 2827 3696 A tricyclic antidepressant. SGTC_673 1082-0474 110 µM -0.234803871855445 0.408879786962638 no 2016 0.407180481221829 2838 3098046 SGTC_580 1123-0028 41 µM -0.237552013513634 0.407852472731019 no 2017 0.406114286385904 2818 1677248 YPR107C YTH1 SGTC_3042 9091578 49.47 µM -0.240792406704121 0.406641958292976 no 2018 0.404858007534565 2825 25236497 SGTC_1446 4239-0190 62 µM -0.241232778627385 0.406477517009243 no 2019 0.404687353626818 2852 1340085 SGTC_2436 5633522 8.09 µM -0.241909185172632 0.406224969092886 no 2020 0.404425266374413 2979 5724242 SGTC_80 0159-0065 512.242 µM -0.242279258602591 0.406086812371541 no 2021 0.40428189215937 2790 1548079 SGTC_1509 1326-1131 80 µM -0.243696308948503 0.405557903915619 no 2022 0.403733016118348 2875 768313 SGTC_2898 9056270 58.44 µM -0.244654398259538 0.405200398474403 no 2023 0.403362019989067 2801 19154699 SGTC_620 0109-0052 432 µM -0.245056855064529 0.405050247635414 no 2024 0.403206204569967 2970 493037 SGTC_1315 1237-0019 3.69 µM -0.245128385509158 0.40502356211866 no 2025 0.403178512407536 2939 825140 SGTC_2910 7948405 25.97 µM -0.245137764203414 0.405020063287334 no 2026 0.403174881593401 2997 2971328 SGTC_538 2922-0838 53.3 µM -0.248786376726032 0.403659484450869 no 2027 0.401763014824445 3029 777039 SGTC_2733 amorolfine 100 µM -0.249070824359979 0.403553461795116 no 2028 0.401652998593085 2875 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2215 7188065 200 µM -0.249272516349478 0.403478289086894 no 2029 0.401574994606629 2972 940217 SGTC_2144 5628481 200 µM -0.249672594990076 0.403329186159359 no 2030 0.401420276574639 2844 2818399 SGTC_2616 abietic acid 100 µM -0.250364294197662 0.403071434058551 no 2031 0.401152819782978 2960 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2848 9016370 25.97 µM -0.250742757693612 0.402930422710958 no 2032 0.401006500288268 2928 7894410 SGTC_2482 5981709 142.65 µM -0.252630434948253 0.40222728373111 no 2033 0.400276904516986 2906 877755 SGTC_3020 9089140 49.47 µM -0.252723518516201 0.402192619291259 no 2034 0.400240936277631 2928 17217859 SGTC_1696 st025591 34.7925 µM -0.252836581778868 0.402150515422151 no 2035 0.400197248861594 2858 2787147 SGTC_1319 1306-0155 43.7 µM -0.253061214601149 0.402066867296295 no 2036 0.400110454899293 2848 3122360 SGTC_2481 5478948 45.16 µM -0.253296457754537 0.401979272933897 no 2037 0.400019566590427 2995 77792 SGTC_958 1222-0007 33 µM -0.254462234480128 0.401545260902026 no 2038 0.399569238271787 3030 7312461 SGTC_2713 st079149 53.4 µM -0.254810972521584 0.401415451286747 no 2039 0.399434550054621 2938 3103253 SGTC_1195 1502-0147 41.1 µM -0.255071755963814 0.40131838783166 no 2040 0.399333839132663 2857 817940 SGTC_3216 9129716 49.47 µM -0.255309770582125 0.401229804235319 no 2041 0.399241927059366 2893 8056934 SGTC_136 0097-0015 404.482 µM -0.255436510301046 0.401182636682236 no 2042 0.399192987342539 2851 4861337 SGTC_2021 4019055 173 µM -0.255654148754746 0.401101643545031 no 2043 0.399108951368127 2991 44827708 YER133W GLC7 SGTC_2023 5144124 124 µM -0.25571262574234 0.401079882330611 no 2044 0.39908637265034 2858 2830192 SGTC_845 0330-0138 4.51 µM -0.255791645930566 0.401050476801709 no 2045 0.399055862474684 2940 9039800 SGTC_2740 felodipine 17.08 µM -0.256550256575932 0.400768206003266 no 2046 0.398762989691301 2971 3333 L-type calcium channel blocker SGTC_2403 6032726 181.2 µM -0.256790160407419 0.400678951162765 no 2047 0.398670383147413 2935 2881040 SGTC_1311 1190-0148 100 µM -0.257029519804519 0.400589904043519 no 2048 0.398577992448952 2991 1961333 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.258125309497027 0.400182311478027 no 2049 0.398155099563747 2900 6708561 SGTC_1838 st055369 84.5 µM -0.25835479540706 0.400096965099315 no 2050 0.398066550292369 2837 676036 SGTC_1553 gossypol 38.6 µM -0.259452004441752 0.399688976347916 no 2051 0.397643254618232 2836 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1892 st058411 7.36 µM -0.262421057342494 0.398585507074307 no 2052 0.396498419985237 3003 3934738 SGTC_294 k038-0071 157 µM -0.26337233894676 0.398232127587186 no 2053 0.39613180426073 2908 24152826 SGTC_3056 9094900 49.47 µM -0.263681284030068 0.398117379450846 no 2054 0.396012759232493 2911 25236784 SGTC_2821 7996764 71.43 µM -0.26906372661052 0.396119659159652 no 2055 0.393940321688641 3109 2987135 SGTC_2447 5741742 33.78 µM -0.269228309774699 0.396058615972337 no 2056 0.393876998114699 2963 1776504 SGTC_2948 9070189 9.45 µM -0.269987313855332 0.395777137626185 no 2057 0.393585006696487 3034 6473636 YDL196W YDL196W SGTC_2 0422-0095 29 µM -0.270309955810374 0.39565750159397 no 2058 0.393460903365825 2906 6790840 SGTC_1758 st042942 75.2445 µM -0.271203678327908 0.395326159552655 no 2059 0.393117192034184 2879 669317 SGTC_536 3852-0578 10.6 µM -0.272063478207524 0.39500746551912 no 2060 0.392786605417756 3059 2869208 SGTC_674 0498-0004 451 µM -0.272561058892042 0.394823063976713 no 2061 0.39259532467718 2948 4231473 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.273111173005185 0.394619221164668 no 2062 0.392383879148609 2941 676296 Flavone; oxidizing agent. SGTC_2305 7443522 69.23 µM -0.273153140354805 0.394603671497458 no 2063 0.392367749601645 2880 5415886 SGTC_680 0417-1641 114 µM -0.273360392576167 0.394526883238371 no 2064 0.392288097904222 2871 2835990 SGTC_1359 1582-0056 520 nM -0.273598896953318 0.394438520929732 no 2065 0.392196440883997 2998 3661189 SGTC_584 0986-0246 15.4 µM -0.273705601806432 0.394398990134112 no 2066 0.392155436239916 2889 53315 YDR232W HEM1 SGTC_3285 9112818 20.8695 µM -0.274400622284403 0.39414153351292 no 2067 0.391888382421843 2871 17017947 YPR165W RHO1 SGTC_310 1273-0058 1.06 µM -0.275516538792155 0.39372826104674 no 2068 0.391459710603216 3016 2734232 SGTC_1274 0865-0114 173 µM -0.278274891853993 0.392707237215045 no 2069 0.390400674306664 2933 870624 SGTC_844 0330-0132 15.3 µM -0.278773953007752 0.392522584837444 no 2070 0.390209152404989 3017 2828079 SGTC_3162 9099653 49.47 µM -0.281302694555988 0.391587324389613 no 2071 0.389239121883879 3002 25237511 SGTC_1841 st054148 70 µM -0.281532839339995 0.391502235864544 no 2072 0.389150872025456 2989 675442 SGTC_2979 9012552 45.46 µM -0.283287639092541 0.390853626872945 no 2073 0.388478175967223 3010 17100905 SGTC_2987 9018338 71.43 µM -0.283689127650616 0.390705271294423 no 2074 0.388324313726102 2942 5055682 SGTC_56 0957-0365 83.25 µM -0.28386132315438 0.390641647545943 no 2075 0.388258328705381 3037 6752360 SGTC_1281 0884-0031 11.8 µM -0.284243057078785 0.390500612823125 no 2076 0.388112060425228 2915 1548255 SGTC_2710 st078562 53.7235 µM -0.284954777342231 0.390237700428644 no 2077 0.387839394283876 2874 17250908 SGTC_2269 7935389 174.42 µM -0.286019220587652 0.389844584415498 no 2078 0.387431700167957 2883 97605 SGTC_1412 3909-8563 178 µM -0.286250460984727 0.389759198498148 no 2079 0.387343148806372 3006 23767530 SGTC_1628 st004252 77.7 µM -0.28727192798635 0.389382083747616 no 2080 0.38695205769844 3073 692968 SGTC_2984 9022109 38.96 µM -0.288165578792926 0.38905224278071 no 2081 0.386609997924995 3016 6459207 SGTC_1559 coumarin 343 70.1 µM -0.288219460626505 0.389032357883314 no 2082 0.386589376565975 3069 108770 A hepatotoxic, DNA x-linker. SGTC_722 3534-0461 190 µM -0.291664848826797 0.387761455382705 no 2083 0.385271443868729 2962 658262 SGTC_250 brefeldin a 552.239 µM -0.291951735980728 0.387655685140271 no 2084 0.3851617630642 2897 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1882 5615643 20 µM -0.292945619969976 0.387289322126516 no 2085 0.384781858982849 2946 2253075 SGTC_1392 3455-1037 33.9 µM -0.293179625329065 0.387203078245276 no 2086 0.384692428407353 3074 981132 SGTC_976 1348-1067 47.6 µM -0.293862024807112 0.386951608205807 no 2087 0.384431668668391 2958 5310671 YGL099W LSG1 SGTC_2126 5251174 33.877 µM -0.294392643390943 0.38675610350763 no 2088 0.384228943851617 3094 790722 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.29478530720764 0.386611446293002 no 2089 0.38407894555378 3026 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1808 st050063 61.5 µM -0.296293595472877 0.386055940061775 no 2090 0.383502938282564 3087 4011993 SGTC_3262 9137218 49.47 µM -0.297474826718013 0.385621052724171 no 2091 0.383052011988689 2845 17650664 SGTC_3283 9109332 35.8195 µM -0.297554767557696 0.385591626537097 no 2092 0.383021500881226 2925 17027281 SGTC_662 k832-1615 104 µM -0.299095100710253 0.385024759370824 no 2093 0.382433742176002 3033 5878478 SGTC_1874 staurosporine 7.6 µM -0.299693047701536 0.384804771459583 no 2094 0.382205651066074 3056 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2528 xanthyletin 44.79 µM -0.300027143369311 0.384681872010806 no 2095 0.382078225702872 2923 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1518 st038567 90.8 µM -0.300232903356109 0.384606187512864 no 2096 0.381999754412777 2952 77966 SGTC_262 fenpropimorph 62.5 µM -0.30036825178105 0.38455640482971 no 2097 0.381948138829586 2913 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_545 4218-0007 221 µM -0.301392618233878 0.384179693031331 no 2098 0.381557561289935 3052 2840508 SGTC_2131 toluylene red 5.2905 µM -0.301463341429452 0.384153688537359 no 2099 0.381530599904946 2963 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_827 3253-0474 693 µM -0.303021571968519 0.383580869049124 no 2100 0.380936710978006 3073 5402065 SGTC_1796 st049173 110.4 µM -0.303072503904522 0.38356215029964 no 2101 0.380917303996625 3043 94134 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.303501856907622 0.383404363229373 no 2102 0.380753716280827 2986 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2012 4023501 200 µM -0.303956212234036 0.383237408873276 no 2103 0.380580625648259 3020 3477460 SGTC_2150 5556613 200 µM -0.304179241903166 0.383155463821593 no 2104 0.380495669290915 2969 743190 SGTC_1896 st058441 89 µM -0.30528140439458 0.382750586618397 no 2105 0.380075918757741 2987 688759 SGTC_1440 4100-1550 40 µM -0.305744576411396 0.38258047949854 no 2106 0.3798995651919 2973 742806 SGTC_801 0866-0028 10.1 µM -0.306732208546246 0.382217831937315 no 2107 0.379523605946088 2907 6849771 SGTC_2950 9072895 21.46 µM -0.308807669528919 0.381456082654597 no 2108 0.378733917334713 3077 17332245 SGTC_2492 derrusnin 100 µM -0.309674564514061 0.38113804489318 no 2109 0.378404223566244 2879 1715307 Part of coumarin class of compounds. SGTC_2444 5485484 36.41 µM -0.309931828533307 0.38104367787814 no 2110 0.378306399040133 3080 6790631 SGTC_1068 loratadine 26.9 µM -0.311024976205683 0.380642779334359 no 2111 0.377890817189052 3001 3957 A H1 histamine antagonist. SGTC_3028 9087778 49.47 µM -0.31187688950483 0.380330439361086 no 2112 0.377567043313301 2942 17217395 SGTC_1772 st048439 82.2 µM -0.312465835874002 0.380114557472864 no 2113 0.37734326159623 3039 2927068 YDL195W SEC31 SGTC_1768 st044301 37.178 µM -0.312680759517723 0.380035785196138 no 2114 0.3772616073967 2997 3931349 SGTC_1464 k208-0027 110 µM -0.314009448746538 0.379548914117824 no 2115 0.376756931206383 3151 X1464 SGTC_1076 itraconazole 331 nM -0.315943359054622 0.378840613469511 no 2116 0.376022750231893 2977 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2666 tannic acid 100 µM -0.317725679663031 0.378188193069269 no 2117 0.375346515130861 3042 16134267 A thiamine antagonist. SGTC_1239 0337-0584 35.4 µM -0.318061309216081 0.378065374294248 no 2118 0.375219215786306 3136 914301 YML130C ERO1 SGTC_3233 9132340 49.47 µM -0.318226565035753 0.378004905846306 no 2119 0.375156541680367 2964 17682950 SGTC_3182 9108849 49.47 µM -0.318466328865286 0.377917179625716 no 2120 0.375065615894875 3068 17133045 SGTC_1805 st050013 60.3 µM -0.318965757561142 0.37773446589307 no 2121 0.374876239538954 3019 4037144 SGTC_2504 purpurogallin 52.29 µM -0.319148923333888 0.377667462375715 no 2122 0.374806793205269 2930 5281571 An antioxidant. SGTC_280 3448-3607 3.04 µM -0.319560741014161 0.377516829590468 no 2123 0.37465066953773 3065 626179 SGTC_3103 9120822 49.47 µM -0.321800362144648 0.376697957917609 no 2124 0.373801969964963 3192 17141819 SGTC_1314 1222-0010 41.1 µM -0.321913663122526 0.376656546435482 no 2125 0.373759051021677 3017 3526027 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.322493408664731 0.376444671790058 no 2126 0.373539465191508 3023 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2303 7774051 200 µM -0.323237702924208 0.376172715505418 no 2127 0.373257614680028 3164 2953184 SGTC_2563 tomatine 8.54 µM -0.323702932314598 0.376002757422809 no 2128 0.373081475314348 3177 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_430 0958-0115 16.4 µM -0.324431290363709 0.375736721213804 no 2129 0.372805766730116 3001 6833180 SGTC_1644 st010134 20.9 µM -0.32475481668442 0.375618570637243 no 2130 0.372683321771616 3090 3818134 SGTC_3321 9137793 26.8275 µM -0.325096315365881 0.375493869276275 no 2131 0.372554088772648 3023 4904192 SGTC_2090 5301565 104.445 µM -0.325140420278059 0.375477764913126 no 2132 0.372537399241364 2988 2056344 SGTC_1194 1488-0194 225 µM -0.327506870761728 0.374614003612477 no 2133 0.371642273570533 2946 1391452 SGTC_2446 5162541 200 µM -0.329247707834795 0.373978994147515 no 2134 0.370984232803699 2953 1549321 SGTC_346 4513-0042 7.16 µM -0.329474217589842 0.373896394718548 no 2135 0.370898639234372 2962 2827372 SGTC_1365 1672-3266 55.4 µM -0.329745164191077 0.373797598480569 no 2136 0.370796262247686 3093 6415873 SGTC_2966 9084041 48.03 µM -0.331206663667747 0.373264829782394 no 2137 0.37024419357303 2896 17741380 SGTC_604 1000-0114 314 µM -0.3316062180229 0.373119220082052 no 2138 0.370093311861833 3130 1572745 SGTC_1225 1216-0074 20.6 µM -0.334317672539064 0.372131563700449 no 2139 0.369069928071059 3010 4241466 SGTC_1294 1000-1494 117 µM -0.334635432406265 0.372015873511586 no 2140 0.368950056594048 3023 712797 YDL207W GLE1 SGTC_593 1203-0218 61.7 µM -0.33471034559824 0.371988600757611 no 2141 0.368921798257923 3134 3666956 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.336254513192739 0.371426577289377 no 2142 0.368339474010494 3004 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1482 3346-2049 8.48 µM -0.33682501623899 0.371219003214453 no 2143 0.36812440682778 3075 3826804 SGTC_2880 9042983 58.44 µM -0.337192213646528 0.371085420472241 no 2144 0.367986003282757 3123 6464714 SGTC_2991 9074669 71.4286 µM -0.337284654744906 0.371051793772316 no 2145 0.367951163209553 3181 17333109 SGTC_711 k292-0785 179 µM -0.337743785939284 0.370884793183652 no 2146 0.367778137614766 2968 4146315 SGTC_2127 5253358 187.912 µM -0.337863635476553 0.3708412041039 no 2147 0.367732976207854 2916 20612 SGTC_117 lucigenin 22.078 µM -0.338741520178577 0.370521969448864 no 2148 0.367402229652792 3073 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1967 st070177 51.4 µM -0.339211991096013 0.370350923720152 no 2149 0.367225018321356 3147 5729214 SGTC_391 gliotoxin 8.33 µM -0.339799941472001 0.370137202862793 no 2150 0.367003595995812 3162 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_519 k048-0011 62.8 µM -0.339921002685254 0.370093201902503 no 2151 0.366958009788099 3090 6836379 SGTC_2336 9001819 198.65 µM -0.340237956699828 0.369978009715057 no 2152 0.366838668048865 3238 2989602 SGTC_2952 9073731 13.78 µM -0.34078099785006 0.369780676661881 no 2153 0.366634228320739 3036 16457353 SGTC_179 1273-0063 6.77 µM -0.342598262477581 0.369120559427378 no 2154 0.365950354696155 2991 3108139 SGTC_2298 7976326 193.81 µM -0.342888540000776 0.369015152462429 no 2155 0.365841156735692 2980 2235818 SGTC_182 3448-4371 550.524 µM -0.346031689445836 0.367874429267472 no 2156 0.364659449711362 3041 3491403 SGTC_1415 3966-0071 78.1 µM -0.346039349738025 0.367871650584717 no 2157 0.364656571292019 3072 2893185 SGTC_352 k048-0007 5.11 µM -0.346231250047573 0.367802043214529 no 2158 0.364584465623704 3110 6811911 SGTC_1853 st056710 91.2 µM -0.348846708639722 0.366853780192973 no 2159 0.363602197532805 3172 269167 SGTC_1810 st050138 53 µM -0.348982522453349 0.366804561539875 no 2160 0.363551215376661 3149 3444541 SGTC_1220 1838-0075 193 µM -0.349786072069411 0.366513401601987 no 2161 0.363249626219997 3042 5529645 SGTC_939 1165-0479 45.3 µM -0.35006800274355 0.366411264413682 no 2162 0.363143831754986 3148 1377347 SGTC_2922 7999257 32.47 µM -0.35062328311488 0.366210126408176 no 2163 0.362935493375872 3046 2988377 SGTC_2621 lithochol-11-enic acid 100 µM -0.351217134134241 0.365995057712756 no 2164 0.362712728368722 3137 6708711 SGTC_2734 clemastine 41.6 µM -0.351611324316574 0.365852321297791 no 2165 0.362564885654046 3054 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3107 9121808 49.47 µM -0.351713303205164 0.365815397725746 no 2166 0.362526641370772 3014 662681 SGTC_1650 st011916 45.8 µM -0.352477518721561 0.365538737225775 no 2167 0.362240087744693 3151 242528 SGTC_2552 juarezic acid 87.02 µM -0.353018210723753 0.365343038710091 no 2168 0.362037394093293 2996 1549512 SGTC_3325 9138760 55.175 µM -0.353108395940483 0.365310400407114 no 2169 0.362003589383434 3042 43844959 SGTC_2659 sanguinarine 24.21 µM -0.353880828600245 0.365030894667925 no 2170 0.361714097558591 3006 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1932 st074806 40.9 µM -0.354545821336296 0.36479032362633 no 2171 0.361464935373979 3261 17251235 SGTC_899 1083-0020 478 µM -0.354572486822637 0.364780678098215 no 2172 0.361454945465287 3198 767123 SGTC_3140 9094243 49.47 µM -0.356399762333918 0.364119914121563 no 2173 0.36077060366714 3112 19291112 SGTC_2071 5230951 39.92 µM -0.356617031316282 0.364041373961199 no 2174 0.360689262806388 3115 1799272 SGTC_1930 st074634 34.3 µM -0.357685404965387 0.363655252692772 no 2175 0.360289378310136 3003 684253 YOR116C RPO31 SGTC_2007 4011539 71.82 µM -0.359129439301554 0.363133583846522 no 2176 0.359749129631995 3005 45595301 SGTC_2231 micatex 6.853 µM -0.359246873834407 0.363091170837801 no 2177 0.359705206794043 3087 20737 An antifungal of unknown mechanism. SGTC_3221 9128209 49.47 µM -0.360140019569863 0.362768654616318 no 2178 0.359371213299552 3060 16460723 SGTC_325 2810-4341 181 µM -0.36027902568606 0.362718468052943 no 2179 0.359319241359966 3142 774970 SGTC_492 tmb-8 126 µM -0.36120800728024 0.362383130487765 no 2180 0.358971978359499 3075 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2694 st077685 81.9 µM -0.362392805546259 0.361955603126649 no 2181 0.358529257504024 2995 2838096 SGTC_2072 5231554 129 µM -0.362821470730356 0.361800964254932 no 2182 0.358369125956511 3168 789545 SGTC_719 2810-4230 27.3 µM -0.363303536251505 0.361627088427608 no 2183 0.358189076007217 3064 721079 SGTC_2076 5212012 200 µM -0.363517448699158 0.361549941666753 no 2184 0.358109190481585 3048 604802 SGTC_3086 9117350 49.47 µM -0.36402172884167 0.361368097110134 no 2185 0.35792089183413 3111 2679265 SGTC_1436 4092-1007 8.32 µM -0.365564095943041 0.360812110570308 no 2186 0.357345185300565 3064 2881121 SGTC_2106 5357045 167.29 µM -0.36623262295783 0.360571213804586 no 2187 0.357095750526924 3139 668842 SGTC_890 0929-0006 47.2 µM -0.366280735554817 0.360553879062974 no 2188 0.35707780154271 3052 1378169 SGTC_1525 8-methoxypsoralen 92.5 µM -0.36753667853916 0.360101470209022 no 2189 0.356609368880082 3274 4114 Related to psoralen; DNA damaging agent. SGTC_2741 miltefosine 3.04 µM -0.367801688961977 0.360006034620196 no 2190 0.356510554780141 3053 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2274 7947094 46.08 µM -0.368096363083983 0.359899926781472 no 2191 0.356400691323073 3047 2971028 SGTC_1607 st000305 50.6 µM -0.368847510556128 0.359629498420621 no 2192 0.356120694666424 3188 5457690 SGTC_2282 7944268 200 µM -0.369296318979605 0.35946795179276 no 2193 0.355953434489902 3251 2970414 SGTC_1659 st012954 42.1 µM -0.369666977200488 0.35933455392167 no 2194 0.355815319925413 3174 24207262 SGTC_909 3448-9333 149 µM -0.370199646104908 0.359142879314474 no 2195 0.355616870126142 3035 3344074 SGTC_2655 perillic acid 100 µM -0.371306755620179 0.358744612502027 no 2196 0.35520453339985 3069 5702197 An apoptosis inducer. SGTC_2099 5377090 177.372 µM -0.372220788898612 0.358415917787015 no 2197 0.354864234528091 3147 2243829 SGTC_2244 6635614 200 µM -0.372632421587394 0.358267925147369 no 2198 0.354711019539055 2952 836499 SGTC_3309 9129340 25.759 µM -0.37289113026045 0.358174923555333 no 2199 0.354614736862929 3093 17158987 SGTC_1615 st002656 86.5 µM -0.37440069392422 0.357632427733973 no 2200 0.354053113375069 3107 1584458 SGTC_1127 asiatic acid 681.4 nM -0.374856712843064 0.357468603521058 no 2201 0.353883516817806 3042 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_176 1486-1328 72.834 µM -0.37571849003886 0.357159082895533 no 2202 0.353563095159054 3117 22310231 SGTC_2159 5658611 73.75 µM -0.378682108467408 0.356095371833713 no 2203 0.352461970490033 3183 793844 SGTC_1283 0922-0125 16.4 µM -0.379037240483807 0.355967981675857 no 2204 0.352330104822613 3157 3360884 SGTC_2258 7960471 200 µM -0.379928373653245 0.355648392230042 no 2205 0.351999292334067 3138 2974708 SGTC_248 streptozotocin 5.23457 mM -0.382027158743226 0.354896100546993 no 2206 0.351220609974643 3163 5300 DNA alkylating agent. SGTC_43 0570-0105 72.5 µM -0.382126167408879 0.354860625675049 no 2207 0.351183891590632 3072 1114046 YDL195W SEC31 SGTC_1053 3366-3204 134 µM -0.382793773792328 0.354621454719763 no 2208 0.350936339162623 3111 3632071 YPR165W RHO1 SGTC_878 0828-0289 13.7 µM -0.383583481477464 0.354338614780839 no 2209 0.350643592518062 3096 745350 YLR208W SEC13 SGTC_1040 k898-0338 155 µM -0.385317455558448 0.353717860484981 no 2210 0.350001115216163 3273 20969351 SGTC_2173 5763948 167 µM -0.386773126656075 0.353197037377192 no 2211 0.349462086839162 3114 2867177 SGTC_2636 apigenin dimethyl ether 100 µM -0.387005517213378 0.353113916008426 no 2212 0.349376061733144 3224 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2693 st077581 40.7 µM -0.3878366368071 0.35281669883287 no 2213 0.349068465621436 3218 25238761 SGTC_1519 esterone 74 µM -0.389345923999775 0.352277191450034 no 2214 0.348510134298355 3067 698 A steroid. SGTC_3057 9095946 49.47 µM -0.390309131625646 0.351933040040932 no 2215 0.348153985835275 3074 24540043 SGTC_2826 7992541 19.48 µM -0.3903443069386 0.351920474292776 no 2216 0.348140982206008 3090 2985066 SGTC_1196 1588-0294 184 µM -0.391050702181848 0.351668161544281 no 2217 0.347879879433396 3139 6144269 SGTC_986 1493-0483 84 µM -0.391104824493179 0.351648832638843 no 2218 0.347859877337395 3205 40079 SGTC_940 3232-1287 54.8 µM -0.391450865287035 0.351525258850008 no 2219 0.347732000325679 3186 1585493 YIL048W NEO1 SGTC_297 0986-0032 24 µM -0.392959985192492 0.350986524263226 no 2220 0.347174518025358 3076 2847425 SGTC_1991 st073000 8.92 µM -0.392996909429303 0.350973346577908 no 2221 0.347160882022058 3278 4301969 YIL048W NEO1 SGTC_2262 9014885 67.46 µM -0.393048506403888 0.350954932721108 no 2222 0.347141827754773 3063 6457424 SGTC_3206 9114350 49.47 µM -0.393111510030144 0.350932448548908 no 2223 0.347118561644558 3188 17087243 SGTC_1898 st060199 18.6 µM -0.394712174235461 0.350361393056431 no 2224 0.34652765853702 3084 688866 SGTC_2340 7987427 183.45 µM -0.395902478396596 0.349936957362659 no 2225 0.346088486321379 3224 2239331 SGTC_1661 st013063 9.66 µM -0.397234351376266 0.349462263610346 no 2226 0.345597326470536 3111 721395 SGTC_3267 9137951 49.47 µM -0.400587122671807 0.348268343358009 no 2227 0.34436206404089 3042 16643986 SGTC_1956 st077085 54 µM -0.402323039527146 0.347650773575298 no 2228 0.343723150417814 3136 24208685 SGTC_2367 9070478 135.38 µM -0.402783480864294 0.347487034700046 no 2229 0.343553757266241 3077 572802 SGTC_2704 st078022 71.1 µM -0.405334141183422 0.346580503121399 no 2230 0.342615956961226 3266 54697681 SGTC_2458 5808907 16.39 µM -0.407897718679675 0.345670265066213 no 2231 0.34167438384685 3259 2731747 SGTC_1108 betulinic acid 729.144 nM -0.409793930318115 0.344997558850769 no 2232 0.340978559545309 3170 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1230 0170-0365 3.77 µM -0.411755396985953 0.344302217677231 no 2233 0.34025935831509 3265 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2369 9071472 200 µM -0.412222806966647 0.34413659805758 no 2234 0.340088061001164 3248 17296037 SGTC_1349 flufenamic acid 69 µM -0.414457491445134 0.343345185164913 no 2235 0.339269546118954 3110 3371 A non-steroidal anti-inflammatory. SGTC_90 0870-0863 4.608 µM -0.414563444425342 0.343307678963776 no 2236 0.339230756703371 3104 1738164 SGTC_629 3448-6466 76.7 µM -0.415720601390034 0.342898158530419 no 2237 0.338807232207349 3174 573744 SGTC_326 k292-0812 17.5 µM -0.416468642238244 0.342633523358448 no 2238 0.338533554362273 3215 3579357 SGTC_2942 9052777 62.25 µM -0.417903024861306 0.342126296435575 no 2239 0.338009010425123 3158 6469503 SGTC_2870 9038528 12.99 µM -0.418105129090065 0.342054851127432 no 2240 0.337935127532357 3246 6463316 SGTC_1625 st003711 30.1 µM -0.419671954875747 0.341501158883224 no 2241 0.337362557739823 3343 24207034 YER133W GLC7 SGTC_577 r071-0003 38.6 µM -0.420427991927724 0.341234108832327 no 2242 0.337086411427427 3151 4568517 YMR134W ERG29 SGTC_2996 9066192 71.4286 µM -0.420439085039652 0.341230191075984 no 2243 0.337082360265825 3169 6472854 SGTC_1052 3253-3998 198 µM -0.422092677088824 0.340646383290249 no 2244 0.336478686395708 3096 5450317 SGTC_898 1000-0849 28.3 µM -0.422648114317101 0.340450369321356 no 2245 0.336276008361221 3229 6751807 SGTC_2796 7949634 45.45 µM -0.42377270767911 0.340053631971334 no 2246 0.335865792016388 3116 2971588 SGTC_2152 5568786 200 µM -0.424151042489225 0.339920201682715 no 2247 0.335727831273789 3202 5399883 SGTC_2083 5306046 65.942 µM -0.424713251991876 0.339721959912393 no 2248 0.335522861055255 3177 539837 SGTC_551 k048-0028 34.9 µM -0.425728540410853 0.339364069448993 no 2249 0.335152831443552 3280 6836383 SGTC_2413 inermin 26.06 µM -0.425900901758558 0.339303326227451 no 2250 0.335090028904132 3375 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2832 7992762 51.95 µM -0.425911268755887 0.339299672845298 no 2251 0.335086251674283 3043 2985177 SGTC_501 nsc-95397 161 µM -0.426265707755577 0.339174775843007 no 2252 0.334957121368156 3304 262093 SGTC_3097 9117246 49.47 µM -0.428335657084831 0.338445721649244 no 2253 0.334203381134007 3213 16423892 SGTC_666 0272-0154 136 µM -0.428619215145183 0.338345897094645 no 2254 0.334100179786722 3194 6870312 SGTC_2958 9077254 16.72 µM -0.428812555414151 0.33827783957116 no 2255 0.33402982051996 3354 16457351 SGTC_966 1300-0360 30.2 µM -0.429738958133491 0.337951810776781 no 2256 0.333692770400359 3154 70588 SGTC_281 1672-3440 14.9 µM -0.429759045693698 0.337944742709425 no 2257 0.333685463493158 3259 6833000 SGTC_3032 9089427 49.47 µM -0.431799103515556 0.337227219959461 no 2258 0.332943715576493 3237 17173707 SGTC_1397 3532-0190 20.1 µM -0.433002394241966 0.336804279535717 no 2259 0.33250651522138 3076 5322280 SGTC_1926 methyl fluorone black 53.6 µM -0.434726648022775 0.336198587328055 no 2260 0.331880426680675 3165 72721 Reacts with homocysteine. SGTC_1421 4029-0249 71.4 µM -0.435119222725553 0.336060743857417 no 2261 0.331737945585369 3312 2894095 SGTC_2508 celastrol 40.54 µM -0.435502485426437 0.335926191344539 no 2262 0.331598867665711 3199 122724 Celastrol is a natural product and antioxidant. SGTC_520 3584-0023 682 µM -0.435551363180871 0.335909033281847 no 2263 0.331581132631996 3191 1340790 SGTC_2396 5342950 42.78 µM -0.435639077550918 0.335878242858623 no 2264 0.331549306885226 3229 1886677 SGTC_1719 st032227 49.2 µM -0.435865868008026 0.33579863758696 no 2265 0.331467025257198 3162 3125804 SGTC_1136 pergolide 1.05886 µM -0.43734750016436 0.33527875421947 no 2266 0.330929676003777 3126 47811 A dopamine receptor agonist. SGTC_1295 1013-0063 9.78 µM -0.437438828595051 0.335246718696996 no 2267 0.330896564948791 3299 6826038 SGTC_1074 carmofur 3.8 µM -0.438003950050695 0.335048516157145 no 2268 0.330691710008058 3184 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_851 0394-0702 453 µM -0.438640287427135 0.334825391345799 no 2269 0.330461100185618 3311 762646 SGTC_2727 riluzole 51.77 µM -0.44204047140971 0.333634143305877 no 2270 0.329229959906301 3237 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2455 5377712 9.75 µM -0.444338374052697 0.332830025255108 no 2271 0.328398980552684 3238 2243908 SGTC_2647 atorvastatin 60.16 µM -0.445976727181295 0.332257175992517 no 2272 0.327807028534589 3233 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1393 3470-5649 58.2 µM -0.447146932553488 0.331848254035934 no 2273 0.327384487218598 3234 4108395 SGTC_1226 3909-7979 35.4 µM -0.449185501812298 0.331136365471001 no 2274 0.32664892263421 3298 6615510 SGTC_1451 4152-0210 104 µM -0.450361051836083 0.33072612886033 no 2275 0.32622506194291 3332 659563 SGTC_1506 4226-2149 212 µM -0.450383647541997 0.330718245531567 no 2276 0.326216916947125 3270 991114 SGTC_400 oxethazaine 37.5 µM -0.451578722711703 0.330301407438877 no 2277 0.325786250549645 3264 4621 A local anesthetic. SGTC_3133 9127736 49.47 µM -0.45173447545481 0.330247096913878 no 2278 0.325730139408118 3359 27243420 SGTC_1579 chlormadinone acetate 49.4 µM -0.451805745001437 0.330222246624382 no 2279 0.325704465314052 3305 45114258 A steroidal progestin. SGTC_383 2324-0395 7.37 µM -0.455329483564787 0.328994524013508 no 2280 0.324436109048148 3315 3146421 SGTC_1151 3909-8316 15.3 µM -0.455478902650851 0.328942504825081 no 2281 0.32438237106931 3311 800431 SGTC_372 0155-0182 15.9 µM -0.455691019361645 0.3288686635961 no 2282 0.324306090420772 3193 771486 SGTC_1587 estradiol valerate 56.1 µM -0.456581807766175 0.328558638814618 no 2283 0.323985828826126 3339 13791 A steroid. SGTC_416 estradiol valerate 100 µM -0.457065455265262 0.328390362374008 no 2284 0.323811999509712 3271 13791 A steroid. SGTC_2088 5278280 127.392 µM -0.457692274146053 0.328172323819837 no 2285 0.323586769673874 3312 791502 SGTC_306 1672-3436 11.6 µM -0.45802895277366 0.328055234527388 no 2286 0.323465820290305 3295 6797378 SGTC_611 3453-1652 23.7 µM -0.459120253833246 0.327675820626575 no 2287 0.323073906461845 3324 1560575 SGTC_1905 st060207 84.5 µM -0.459463551487679 0.327556502690708 no 2288 0.322950660160263 3175 1948547 SGTC_3159 9100096 49.47 µM -0.459925225258367 0.327396069234624 no 2289 0.322784946640644 3179 25236875 SGTC_1045 1348-1485 165 µM -0.460339408572516 0.327252166022405 no 2290 0.322636309319829 3224 6810614 SGTC_2580 diallyl disulphide 81.36 µM -0.461022401207832 0.327014924191848 no 2291 0.322391266718088 3204 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_252 miconazole 1.30953 nM -0.461597786427683 0.326815114716265 no 2292 0.322184891136849 3273 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2855 9016525 58.44 µM -0.465078997766401 0.325607282654572 no 2293 0.320937442772467 3233 43811474 SGTC_283 0987-0079 11.7 µM -0.465093431377679 0.325602278604579 no 2294 0.320932274861821 3315 411556 SGTC_527 4476-4215 268 µM -0.465663455106146 0.325404679795707 no 2295 0.320728207346341 3204 4418754 SGTC_2614 arthonioic acid 13.39 µM -0.465689895669109 0.3253955153611 no 2296 0.320718742984204 3274 6710684 SGTC_3046 9092212 49.47 µM -0.466201966511284 0.325218049810868 no 2297 0.320535470939513 3281 25236637 SGTC_3142 9086498 49.47 µM -0.468517156367586 0.324416182489417 no 2298 0.319707402516943 3275 25236367 SGTC_2428 5615643 7.78 µM -0.470909016688635 0.323588614517745 no 2299 0.318852854402295 3295 2253075 SGTC_1031 k035-0009 16 µM -0.471205918953667 0.32348594902018 no 2300 0.318746846153954 3359 5180959 SGTC_1189 1431-2119 7.28 µM -0.472029447744985 0.323201252272804 no 2301 0.318452884792129 3329 3107275 SGTC_1812 st052057 4.327 µM -0.472116516613254 0.323171158312381 no 2302 0.318421811943261 3217 3645418 SGTC_2321 7390090 138.78 µM -0.472673866999831 0.322978546494392 no 2303 0.318222936851004 3246 649046 SGTC_1457 k015-0032 57.3 µM -0.472895412746265 0.322901996833852 no 2304 0.318143898917695 3305 4302660 SGTC_2350 9023895 38.85 µM -0.472936017446476 0.32288796769603 no 2305 0.318129413815903 3351 2997209 SGTC_3072 9116419 49.47 µM -0.473572830439494 0.322667978433382 no 2306 0.317902276984652 3265 17170162 SGTC_1931 st074438 57.1 µM -0.474208601841326 0.322448410892983 no 2307 0.317675579986492 3294 2787313 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.474399364495617 0.322382541917033 no 2308 0.317607573075039 3260 2724278 An inhibitor of dopamine biosynthesis. SGTC_2618 avocadyne 43.43 µM -0.47598857600317 0.321834015469498 no 2309 0.317041258338285 3251 3015189 SGTC_393 acivicin 6.25 µM -0.476816068968712 0.32154855456218 no 2310 0.316746551095967 3184 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1700 st030840 7.9285 µM -0.478307078359739 0.321034465854407 no 2311 0.316215829554227 3321 5499307 SGTC_1201 1889-3372 45.9 µM -0.479211613735364 0.320722755949261 no 2312 0.31589404649172 3212 5392199 SGTC_2607 solasodine 47.35 µM -0.479859412903654 0.320499596970407 no 2313 0.315663681488416 3238 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2123 5259487 200 µM -0.480926217002975 0.320132237280526 no 2314 0.315284469480273 3339 2173474 SGTC_2739 tacrine 100.86 µM -0.481132458520666 0.320061237232653 no 2315 0.315211180170836 3320 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1138 3761-0006 1.03 µM -0.482127703709286 0.319718709953818 no 2316 0.314857615364893 3341 12061087 SGTC_3256 9138902 49.47 µM -0.483410067514165 0.319277593491018 no 2317 0.314402300635778 3287 17228773 SGTC_1203 3992-3522 103 µM -0.48458601779298 0.318873306617469 no 2318 0.313985016981068 3529 5322312 SGTC_693 4161-2696 114 µM -0.485775076188116 0.318464732252977 no 2319 0.313563323649058 3334 805759 SGTC_2364 9055074 200 µM -0.488490548671702 0.31753249218241 no 2320 0.312601209320442 3324 6470630 SGTC_1976 st070609 63.5 µM -0.489201611534961 0.317288570232777 no 2321 0.312349484364465 3282 682556 SGTC_2943 9068529 45.32 µM -0.489637712331086 0.317139010106553 no 2322 0.312195142651683 3346 3270634 SGTC_1164 k060-0068 93.7 µM -0.489848988005674 0.317066564161664 no 2323 0.312120381305719 3298 5963676 SGTC_1255 0566-0045 221 µM -0.490130783336055 0.316969948100755 no 2324 0.312020678138008 3392 2788469 SGTC_813 k007-0158 173 µM -0.493207263129989 0.315915962294931 no 2325 0.310933073201285 3301 6523916 SGTC_1901 st060216 58.6 µM -0.493830453249696 0.31570264242335 no 2326 0.310712962047517 3247 688792 SGTC_1135 dihydrocapsaicin 536.708 nM -0.494084931123173 0.315615551520071 no 2327 0.310623099769416 3268 107982 A Capsaicinoid. SGTC_2866 9034245 58.44 µM -0.503095870511546 0.312538334222687 no 2328 0.307448434951662 3303 6462273 SGTC_1003 4049-0218 100 µM -0.503844059309938 0.312283412047191 no 2329 0.307185481823338 3424 295161 SGTC_2140 5586273 200 µM -0.504715945580504 0.311986457126358 no 2330 0.306879179905697 3358 854421 SGTC_1124 fisetin 1.16336 µM -0.506044839582415 0.311534085387019 no 2331 0.306412586120968 3308 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_251 melphalan 456.522 µM -0.506745550052628 0.311295669435528 no 2332 0.306166682866838 3347 460612 A DNA alkylator. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.50841861312939 0.310726731781934 no 2333 0.305579901085386 3344 91467 include heat shock SGTC_2085 5307070 144.047 µM -0.509122625246158 0.310487462300926 no 2334 0.305333136879819 3255 2840351 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.509368675973124 0.310403857028824 no 2335 0.30524691416806 3519 6728940 SGTC_624 k048-0052 28 µM -0.509396371469634 0.310394447023566 no 2336 0.305237209606798 3305 6835531 SGTC_96 0929-0093 37.281 µM -0.510279578178734 0.31009442797517 no 2337 0.304927803914973 3297 6991579 SGTC_1222 0366-0074 1.18 µM -0.510335204796855 0.310075536236508 no 2338 0.304908321417838 3406 286520 SGTC_1925 st057770 10.1 µM -0.510354075576301 0.310069127515094 no 2339 0.304901712299212 3275 5989122 SGTC_2717 st081029 62.2815 µM -0.51058654950789 0.309990181580068 no 2340 0.304820298108435 3389 5292846 SGTC_944 3370-0224 231 µM -0.511657487969889 0.309626614235364 no 2341 0.304445371917352 3325 4580514 SGTC_2899 9053889 58.44 µM -0.511923598600621 0.309536302585067 no 2342 0.304352240758314 3393 6470052 SGTC_1682 st012968 530 nM -0.512068514647998 0.309487126344349 no 2343 0.304301529594684 3251 24207270 SGTC_1766 st045414 44.774 µM -0.514347429319707 0.308714241758864 no 2344 0.303504553500511 3375 253960 SGTC_525 k781-2675 26.7 µM -0.514999425063911 0.308493275658134 no 2345 0.303276710882197 3409 3651118 YDL195W SEC31 SGTC_2526 patulin 37.61 µM -0.515357656516588 0.308371897924926 no 2346 0.303151557969434 3419 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2204 7233102 200 µM -0.515621702170873 0.308282446092127 no 2347 0.303059324905157 3292 2172480 SGTC_1656 st012921 11 µM -0.516341902083297 0.308038518883177 no 2348 0.302807817691794 3358 6732821 SGTC_2228 7354201 200 µM -0.516776415993311 0.307891392733225 no 2349 0.302656122568823 3341 753451 SGTC_1565 sinapyl alcohol 95.1 µM -0.517033362625255 0.307804405283946 no 2350 0.302566434787917 3367 5280507 A phenol propionate derived from cinnamic acid. SGTC_3106 9121286 49.47 µM -0.517698988940523 0.307579112485081 no 2351 0.302334151894216 3457 15943471 SGTC_2382 9035899 200 µM -0.518045828500235 0.307461747353925 no 2352 0.30221314737953 3309 6462679 SGTC_716 1683-5115 658 µM -0.520125109026601 0.306758564634216 no 2353 0.301488189406222 3428 723597 SGTC_728 3030-5151 22.5 µM -0.520207790427929 0.306730617648105 no 2354 0.301459378051161 3364 3125388 SGTC_1071 trifluoperazine 6.31 µM -0.520399142865112 0.306665943277036 no 2355 0.301392703684872 3446 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_965 1291-5240 308 µM -0.520468491186081 0.30664250602805 no 2356 0.301368541767697 3422 2834598 SGTC_3204 9114183 49.47 µM -0.520563615203248 0.306610358802899 no 2357 0.301335400658887 3292 17027248 SGTC_2714 st079313 56.9 µM -0.520928783891549 0.306486963621059 no 2358 0.301208191510815 3346 2939799 SGTC_1907 st060210 83.7 µM -0.522246754276009 0.306041787079164 no 2359 0.300749268364679 3456 688793 SGTC_2799 7812892 81.82 µM -0.522924682167972 0.305812911921306 no 2360 0.300513333807925 3435 20205235 SGTC_1865 st057639 52.2 µM -0.524840476895427 0.30516653080007 no 2361 0.299847045351799 3368 688818 SGTC_474 dl-dihydrosphingosine 5 µM -0.525815003724387 0.304837962390022 no 2362 0.299508374441317 3448 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2558 carylophyllene oxide 100 µM -0.526123934689703 0.304733837022822 no 2363 0.299401049897741 3435 6708694 An oxygenated terpenoid and antifungal agent. SGTC_300 r073-0011 5.04 µM -0.527278145027301 0.304344949717298 no 2364 0.29900022441288 3438 2735780 SGTC_1262 0737-0114 49.6 µM -0.52728311699707 0.30434327499295 no 2365 0.298998498311844 3457 765919 SGTC_2812 7970281 58.44 µM -0.528939268878442 0.303785656588511 no 2366 0.298423789950265 3446 2233435 SGTC_1915 st067105 30.6 µM -0.529371477823498 0.303640208944661 no 2367 0.298273890026424 3420 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1505 k297-0037 20.6 µM -0.529695065221437 0.3035313351515 no 2368 0.298161684980807 3305 4089396 SGTC_1959 st077091 55.8 µM -0.530982477171795 0.30309834698345 no 2369 0.297715460987465 3334 821356 YKL052C ASK1 SGTC_2575 plumbagin 510 nM -0.531582664593939 0.302896583726781 no 2370 0.297507536941862 3317 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_859 0439-0102 54.6 µM -0.531726678787404 0.302848179840576 no 2371 0.297457655701788 3452 610143 SGTC_2107 5363541 170.161 µM -0.533888893753648 0.302121865404377 no 2372 0.296709203246882 3416 244052 SGTC_2193 5925765 200 µM -0.533920338170712 0.302111308611446 no 2373 0.296698325100617 3419 877370 SGTC_2759 disulfiram 3.38 µM -0.534541717524945 0.301902727717559 no 2374 0.296483397370733 3326 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2925 9010536 32.5 µM -0.534734947309073 0.301837878694213 no 2375 0.296416576032478 3355 2994177 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.535371253335082 0.301624375008116 no 2376 0.296196582056236 3287 6708514 SGTC_969 1313-0238 134 µM -0.535775693313642 0.301488706084893 no 2377 0.296056791492322 3328 5212874 SGTC_1010 4112-3296 15.2 µM -0.536312151896101 0.301308794055533 no 2378 0.295871416775226 3480 704384 SGTC_472 calcifediol 10 µM -0.5370290025189 0.301068459470263 no 2379 0.295623790345236 3405 5283731 A vitamin D metabolite. SGTC_1332 1480-0653 17.5 µM -0.537079420349755 0.30105155941248 no 2380 0.295606377768378 3414 5749438 SGTC_717 1532-0246 73.2 µM -0.53986308087077 0.300119140708062 no 2381 0.294645730141441 3386 9561992 SGTC_3066 9117245 49.47 µM -0.540091521221686 0.300042680041854 no 2382 0.294566958830804 3369 17176980 SGTC_818 4072-2707 53.5 µM -0.543883329835311 0.298774823156426 no 2383 0.293260880546612 3368 882871 SGTC_1724 st037281 8.293 µM -0.545941663847065 0.298087604746884 no 2384 0.292553018850243 3380 574124 YDL195W SEC31 SGTC_1323 1348-1351 11.2 µM -0.546712769497828 0.297830340362585 no 2385 0.292288039968686 3354 6989654 SGTC_1899 st063254 59.6 µM -0.547950519154187 0.297417601151264 no 2386 0.291862939442035 3351 3093813 SGTC_345 1362-0200 395 µM -0.549837788788437 0.29678877678783 no 2387 0.291215318607915 3372 1419823 SGTC_582 0987-0078 156 µM -0.549856498012821 0.296782546059465 no 2388 0.291208901855014 3501 1625765 SGTC_549 1661-1316 519 µM -0.550649240650969 0.296518594215859 no 2389 0.29093707346032 3492 2857282 SGTC_1571 st070080 73.4 µM -0.551048076160612 0.296385838501214 no 2390 0.290800359150967 3493 4315245 SGTC_2611 pyromycin 23.93 µM -0.55254639420222 0.295887354512278 no 2391 0.290287028716428 3353 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2933 9026794 32.47 µM -0.5547283503108 0.295162116513126 no 2392 0.289540240815576 3357 17586027 SGTC_2486 5283202 22.39 µM -0.554843047621673 0.295124016103827 no 2393 0.289501009925073 3367 1377751 SGTC_2248 tofa 1.1 µM -0.555461757329979 0.294918530798747 no 2394 0.289289430480028 3356 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1826 st055655 41.6 µM -0.555641627357468 0.294858804901376 no 2395 0.28922793417175 3412 676168 SGTC_563 tetrahydrosecaminediol 614 µM -0.556017268666136 0.294734091073375 no 2396 0.289099524848852 3481 334274 A psychoactive constituent of the cannabis plant. SGTC_2543 pimpinellin 60.67 µM -0.556050999361592 0.294722893590719 no 2397 0.289087995651075 3325 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_922 1866-0035 480 µM -0.556720088288802 0.294500818603332 no 2398 0.28885934484074 3407 3156169 SGTC_2160 5660466 132.927 µM -0.557557057575058 0.294223131803061 no 2399 0.288573443403404 3447 2859134 SGTC_3268 9137683 49.47 µM -0.557718172653175 0.294169691481131 no 2400 0.288518423197836 3389 1953228 SGTC_2602 kawain 100 µM -0.558598753292037 0.293877690626837 no 2401 0.288217795529604 3462 5369129 SGTC_1726 st035556 14.5795 µM -0.559054951481283 0.29372646788082 no 2402 0.288062108919672 3515 5919439 SGTC_188 3229-0966 278.469 µM -0.560063147737881 0.293392393988057 no 2403 0.287718182959762 3493 5722370 SGTC_2356 9061756 188.97 µM -0.561009311335342 0.29307903533782 no 2404 0.287395594788217 3409 20104043 SGTC_718 1130-0073 349 µM -0.563311924436729 0.292317085331592 no 2405 0.286611249828209 3543 6740020 SGTC_820 1582-0060 59.9 µM -0.56457748888505 0.291898694334557 no 2406 0.286180590174732 3375 3848840 SGTC_1437 4092-1038 11.6 µM -0.564845401935691 0.291810159040127 no 2407 0.286089461324063 3422 3977136 SGTC_2887 9044784 58.44 µM -0.565012992852477 0.291754782839642 no 2408 0.2860324633937 3452 6465546 SGTC_1893 st059353 36.1 µM -0.566773582754673 0.29117333637306 no 2409 0.285434010403436 3429 3112488 SGTC_1624 st003710 6.25 µM -0.567313689378148 0.290995071101422 no 2410 0.285250539005297 3478 24207033 SGTC_3354 9151612 71.43 µM -0.568141905095765 0.290721812871451 no 2411 0.284969307646771 3464 27261949 SGTC_2421 5690543 90.72 µM -0.569907090091009 0.290139815479471 no 2412 0.284370357889681 3465 3397993 SGTC_876 0720-0963 56.8 µM -0.571893145270387 0.289485648667156 no 2413 0.283697184110372 3515 765861 SGTC_1911 st060208 74.3 µM -0.573083759256163 0.289093816660116 no 2414 0.283293991527642 3455 688783 SGTC_312 4092-0653 6.84 µM -0.575331872372965 0.288354641740934 no 2415 0.282533434917959 3471 1148278 SGTC_621 3584-0052 32.1 µM -0.577890098064958 0.287514587997322 no 2416 0.281669160459387 3510 2273927 SGTC_2054 5233173 129 µM -0.584164073506539 0.285459293755547 no 2417 0.279554965008602 3493 6889 SGTC_2314 7727897 200 µM -0.584204679784954 0.285446014342902 no 2418 0.279541306693936 3422 900724 SGTC_339 3091-4833 71.4 µM -0.58513462273835 0.28514197697327 no 2419 0.27922860008905 3485 3240077 SGTC_1145 3546-0597 10.2 µM -0.58523688674689 0.285108552000643 no 2420 0.279194222733762 3424 875334 SGTC_746 1095-0025 46.6 µM -0.585243580122983 0.285106364337007 no 2421 0.279191972741458 3529 6749286 SGTC_540 1187-0821 17.3 µM -0.58534897848875 0.285071916980901 no 2422 0.279156544023602 3424 847520 SGTC_3095 9117207 49.47 µM -0.586324607657121 0.284753146253472 no 2423 0.278828698795833 3464 17015229 SGTC_443 clozapine 122 µM -0.586436131303946 0.284716718579962 no 2424 0.278791234920465 3441 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_502 l-744,832 89.3 µM -0.586572733583581 0.28467210234522 no 2425 0.278745349777727 3486 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_78 0336-0123 156.75 µM -0.587270514712467 0.284444249253323 no 2426 0.278511020231526 3329 6765896 SGTC_2151 5563267 85.4165 µM -0.58756613656971 0.284347743326582 no 2427 0.27841177315653 3441 5310824 SGTC_902 1120-0002 2.07 µM -0.588928973425824 0.283903046908818 no 2428 0.277954460387453 3503 3280475 SGTC_199 4063-0024 41.6 µM -0.590011320548159 0.283550112174633 no 2429 0.27759152996897 3514 306215 SGTC_272 doxorubicin 8.13 µM -0.59184565701241 0.282952447212723 no 2430 0.276976973246556 3504 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1161 k007-0610 110 µM -0.593182224284735 0.282517347063204 no 2431 0.276529603734253 3568 5843850 SGTC_2286 7945697 125 µM -0.594187757794927 0.282190222359567 no 2432 0.27619326996063 3465 1245733 SGTC_1616 st002734 56.1 µM -0.598962325079081 0.280639431680477 no 2433 0.274599004165588 3458 4026101 SGTC_2098 5376439 882.5 nM -0.60099755864723 0.279979638694726 no 2434 0.273920806181117 3532 2844116 SGTC_2938 9059746 27.26 µM -0.602325877602855 0.279549423088914 no 2435 0.273478619350271 3490 6471769 SGTC_1975 st070967 30.8 µM -0.602553797098415 0.27947563685367 no 2436 0.273402782292381 3547 261391 SGTC_29 0299-0004 12.984 µM -0.604456419808596 0.278860054593037 no 2437 0.272770117486051 3435 16871 A napthoquinone isolated from Swertia calycina. SGTC_1637 st007924 17.4 µM -0.605778635627993 0.278432648463447 no 2438 0.272330879195571 3526 683336 SGTC_1946 st076057 65.1 µM -0.607231134086485 0.277963496721263 no 2439 0.271848766569408 3451 953009 SGTC_2813 7971799 71.43 µM -0.607325983299771 0.277932874192183 no 2440 0.271817299038648 3525 2234054 SGTC_1597 7-benzyloxygramine 47.5 µM -0.607831617592172 0.277769655495956 no 2441 0.271649578501257 3512 260807 SGTC_3236 9132701 49.47 µM -0.608209548507276 0.277647690010869 no 2442 0.271524251245409 3501 24282524 SGTC_206 4546-0025 72.014 µM -0.61029790173757 0.276974210831263 no 2443 0.270832243320292 3551 6620745 YIL048W NEO1 SGTC_3299 9121982 43.1275 µM -0.611002705225871 0.27674709732035 no 2444 0.270598894694997 3498 17594604 YPL160W CDC60 SGTC_1250 0485-0349 40.2 µM -0.611094084991029 0.276717658094236 no 2445 0.270568647741693 3481 6842794 YDL195W SEC31 SGTC_2030 5175110 200 µM -0.6169152859782 0.274845448289483 no 2446 0.268645301879625 3592 2831986 SGTC_1759 st043059 70 µM -0.618712239375554 0.274268777349419 no 2447 0.268052972767061 3477 669426 SGTC_225 nsc-122657 1.016 µM -0.61960530063081 0.273982402200138 no 2448 0.26775883806623 3506 275685 SGTC_3091 9116372 49.47 µM -0.619857788510952 0.273901464509903 no 2449 0.267675709273928 3577 17169793 SGTC_1067 clotrimazole 1.36 µM -0.620205116779956 0.273790144036304 no 2450 0.267561376608642 3534 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_842 0271-0008 11.1 µM -0.620566063151937 0.273674482604241 no 2451 0.267442587263379 3599 1221709 SGTC_2595 hexamethylquercetagetin 100 µM -0.620974927158538 0.273543495680451 no 2452 0.267308060110711 3481 386331 SGTC_358 0075-0058 9.45 µM -0.624392181717753 0.272449931778261 no 2453 0.266185029163916 3600 1069125 SGTC_1390 3413-2614 145 µM -0.624544910621796 0.272401107364858 no 2454 0.266134892855505 3558 3421432 SGTC_114 0364-0001 490.298 µM -0.626402276505657 0.271807692207543 no 2455 0.265525558377046 3545 4003655 SGTC_3222 9128301 49.47 µM -0.627017004486154 0.27161143278317 no 2456 0.265324044382198 3538 4911358 SGTC_780 0109-0199 192 µM -0.629647264091783 0.270772487913887 no 2457 0.264462696483354 3612 610414 SGTC_705 1124-0212 310 µM -0.632651186733893 0.269815944870462 no 2458 0.263480726413485 3574 9554485 SGTC_887 0885-0007 9.62 µM -0.633832070445096 0.269440378350316 no 2459 0.263095210567619 3584 5719458 SGTC_2199 6590217 200 µM -0.634422476677165 0.269252704730086 no 2460 0.26290257241207 3511 703109 SGTC_788 1182-0090 188 µM -0.634434030451268 0.269249032762786 no 2461 0.262898803358196 3634 5715185 SGTC_671 0560-0003 407 µM -0.634568679796423 0.269206240979879 no 2462 0.26285488029949 3499 3238678 SGTC_2191 5911152 200 µM -0.635758238379117 0.268828345576295 no 2463 0.262467005463425 3531 2875902 SGTC_1284 0929-0043 16 µM -0.635973489100082 0.268759993848731 no 2464 0.262396850801557 3527 1239883 SGTC_3238 9133470 49.47 µM -0.640649003818785 0.267277466500037 no 2465 0.26087537686468 3605 3534688 SGTC_1200 1643-0193 18.4 µM -0.640655222645326 0.267275497365835 no 2466 0.260873356202779 3586 5403974 SGTC_2886 9058944 51.95 µM -0.643776567575328 0.266288077067023 no 2467 0.259860165384952 3439 4949929 SGTC_8 0354-0001 70 µM -0.643791702042564 0.266283293863141 no 2468 0.259855257676111 3618 4993152 SGTC_877 0771-0151 33.1 µM -0.645896964399427 0.265618355910891 no 2469 0.259173042834466 3564 6166523 SGTC_1338 1486-1223 76 µM -0.647248267412257 0.265191996895122 no 2470 0.258735638529958 3585 3444526 SGTC_2839 9003951 25.97 µM -0.647572934507577 0.265089610724123 no 2471 0.258630603747544 3578 2990634 SGTC_2788 5282734 71.43 µM -0.64811516164612 0.26491866016506 no 2472 0.258455234192081 3623 743706 SGTC_3157 9099274 49.47 µM -0.649065639248022 0.264619133759798 no 2473 0.258147975115821 3587 17217662 SGTC_1640 st009078 66.4 µM -0.649125756114611 0.264600194773897 no 2474 0.258128547621445 3595 690618 SGTC_1958 st076513 41.9 µM -0.650368950549299 0.264208698221069 no 2475 0.257726964266365 3537 732122 YGL099W LSG1 SGTC_2414 st077232 92.9 µM -0.652648473682938 0.263491616761149 no 2476 0.256991463862337 3560 729801 SGTC_1355 1499-0035 1.68 µM -0.652847073754615 0.26342918917636 no 2477 0.256927436229688 3604 1548538 SGTC_2198 6589944 200 µM -0.653001087673807 0.263380781920102 no 2478 0.256877788655982 3560 5290268 SGTC_1591 genipin 88.4 µM -0.653021771703003 0.263374281184143 no 2479 0.256871121380059 3591 442424 A DNA cross-linking agent. SGTC_3255 9139072 49.47 µM -0.654219810051855 0.262997892306797 no 2480 0.256485100233306 3619 17646060 SGTC_132 0417-1715 25.805 µM -0.654856014288802 0.262798127229138 no 2481 0.256280231150027 3644 6769098 SGTC_3305 9127027 53.8275 µM -0.658191139979104 0.261752184995529 no 2482 0.25520765865246 3554 41905295 SGTC_1831 st055328 12 µM -0.660275994313479 0.2610994319295 no 2483 0.254538366152296 3620 1103068 SGTC_257 daunorubicin 18.5 µM -0.660550355694477 0.261013593675719 no 2484 0.25445035752648 3650 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_210 3551-0445 56.827 µM -0.660878890964739 0.260910825365355 no 2485 0.254344992184607 3651 2865180 YOR207C RET1 SGTC_1822 st052468 42 µM -0.661629708922311 0.260676041993664 no 2486 0.254104281423504 3585 2873678 SGTC_2087 5276107 200 µM -0.663050754905573 0.260231973839392 no 2487 0.253649024186375 3604 144405 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.664051364635159 0.259919523493151 no 2488 0.253328718355219 3646 688788 SGTC_25 0118-0223 35.662 µM -0.664874974538399 0.259662488367672 no 2489 0.253065231679926 3655 5333628 SGTC_2427 5545055 42.75 µM -0.66581123143802 0.259370457398952 no 2490 0.252765882526802 3638 5372858 SGTC_160 3453-0671 289.699 µM -0.666110621147464 0.259277109587816 no 2491 0.252670198096941 3589 5322268 SGTC_778 3456-2434 196 µM -0.667141408473537 0.258955849482852 no 2492 0.252340906225785 3656 5539063 SGTC_2700 st077718 96.8 µM -0.667686398585895 0.258786078507141 no 2493 0.25216689697684 3607 904970 SGTC_1254 0550-0035 264 µM -0.668859665894429 0.258420787204334 no 2494 0.251792500730239 3653 15121435 SGTC_1213 1315-0166 115 µM -0.669048607008259 0.258361986252818 no 2495 0.251732235998835 3585 768401 SGTC_144 4161-2749 112.381 µM -0.670435256668399 0.257930654938787 no 2496 0.251290182861453 3559 797501 YMR168C CEP3 SGTC_879 0831-1030 162 µM -0.671209196707995 0.25769007565979 no 2497 0.25104363537308 3650 1549252 SGTC_1992 st073643 23.3 µM -0.671828613345692 0.257497613948099 no 2498 0.250846405332477 3623 3161292 SGTC_3269 9137823 49.47 µM -0.672534569717717 0.257278354169138 no 2499 0.250621720011692 3571 17682936 SGTC_1939 st074455 53.6 µM -0.673229065707814 0.257062748549795 no 2500 0.250400786263669 3661 1644229 SGTC_2129 girgensonine 121.053 µM -0.676394506567342 0.256081232049044 no 2501 0.249395102065511 3673 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1273 0849-0096 14.1 µM -0.677336999146284 0.255789369015193 no 2502 0.249096080448481 3641 5286025 SGTC_1501 4491-0275 38.4 µM -0.679416756701104 0.255145942385795 no 2503 0.248436917756575 3632 5104718 SGTC_2056 5235370 200 µM -0.679477869348914 0.255127048422186 no 2504 0.248417562655858 3627 5511916 SGTC_1027 k015-0025 8.67 µM -0.679886938616217 0.255000596886068 no 2505 0.24828802626174 3625 3598955 SGTC_1787 fluconazole 80 µM -0.681751012787086 0.254424789507877 no 2506 0.247698202409985 3568 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2518 prenyletin 46.28 µM -0.683291160348337 0.253949556736149 no 2507 0.247211439383039 3587 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1428 4049-0204 61.7 µM -0.684194256757805 0.253671111277809 no 2508 0.246926254205105 3693 X1428 SGTC_1173 0443-0020 122 µM -0.684496922075667 0.253577828463339 no 2509 0.246830716149568 3655 5331295 SGTC_3261 9137475 49.47 µM -0.684926272300069 0.253445531708794 no 2510 0.246695223222956 3531 17027690 SGTC_1224 0823-0416 294 µM -0.685803440924859 0.253175360346795 no 2511 0.246418533095958 3684 3598164 SGTC_1989 st071868 50.2 µM -0.687172274963309 0.252754056916558 no 2512 0.245987086721571 3647 16414057 SGTC_893 0958-0369 48.9 µM -0.68720363103374 0.252744410387493 no 2513 0.245977208270672 3659 6819948 SGTC_2467 5474540 200 µM -0.687551980089944 0.252637255685977 no 2514 0.245867478320108 3644 5413519 SGTC_2890 9046729 58.44 µM -0.68809496314436 0.252470277882599 no 2515 0.245696491067362 3590 903329 SGTC_2192 5915882 198.485 µM -0.688307647782751 0.252404889092944 no 2516 0.245629533342701 3615 2876149 SGTC_2838 9002687 71.43 µM -0.688515152179986 0.25234110154524 no 2517 0.245564215916201 3651 6457060 SGTC_2702 st077768 96.8 µM -0.689029519711715 0.252183019888989 no 2518 0.245402345543271 3591 6484119 SGTC_91 0417-1751 58.384 µM -0.689458207823883 0.252051310183676 no 2519 0.24526748212441 3740 6795624 SGTC_438 sphingosine 6.67 µM -0.691401589331939 0.251454683081933 no 2520 0.244656602795407 3577 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2657 nystatin 74.44 µM -0.69288154223032 0.251000831806342 no 2521 0.244191946962831 3679 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_115 0527-0192 112.043 µM -0.694232038339575 0.250587059080206 no 2522 0.24376835179387 3711 4233931 SGTC_1216 1165-0504 9.65 µM -0.694474021188139 0.250512957183248 no 2523 0.243692493636165 3655 6304004 SGTC_95 0471-0001 561.058 µM -0.695582780156951 0.250173572803494 no 2524 0.243345076623449 3601 4015405 SGTC_687 k029-0044 34.9 µM -0.696011257300171 0.250042483913086 no 2525 0.243210889923632 3681 5829338 SGTC_1039 k821-0043 94 µM -0.696039155083957 0.250033950090355 no 2526 0.243202154528532 3631 15992768 SGTC_368 fentichlor 4.58 µM -0.696263233616911 0.249965410951169 no 2527 0.243131996881735 3649 7329 A pesticide. SGTC_2854 9024559 71.43 µM -0.696441839959775 0.249910787580736 no 2528 0.243076084144007 3645 3163529 SGTC_1389 3405-0187 19 µM -0.69678499554304 0.249805857720704 no 2529 0.242968678763654 3627 799890 SGTC_2217 6934799 96.0675 µM -0.697984162245556 0.249439361181053 no 2530 0.242593549379615 3614 675606 SGTC_1780 st038448 24.544 µM -0.698848707925406 0.249175310916217 no 2531 0.24232329252078 3712 728868 YDL195W SEC31 SGTC_3213 9129884 49.47 µM -0.699072262642826 0.249107056845928 no 2532 0.242253435905336 3626 17190742 SGTC_2164 5685496 200 µM -0.699347023550116 0.24902318250642 no 2533 0.242167593278951 3650 759046 SGTC_1737 st035557 69.7 µM -0.699419502590656 0.249001059841812 no 2534 0.24214495164512 3586 5716916 SGTC_829 1635-0120 117 µM -0.700832767325553 0.248569900330009 no 2535 0.241703693157398 3686 285054 SGTC_3208 9114115 49.47 µM -0.701418126674582 0.248391435162107 no 2536 0.241521056455557 3669 650895 SGTC_3290 9121031 71.43 µM -0.701816705689519 0.248269954936067 no 2537 0.241396739583789 3673 17014854 SGTC_747 3448-8087 38.7 µM -0.702630960792105 0.248021882074078 no 2538 0.241142881342121 3698 5168703 SGTC_2810 7959871 45.46 µM -0.702813603036238 0.247966256026674 no 2539 0.241085959368131 3685 2974535 SGTC_2358 9037157 4 µM -0.702872521297909 0.247948313131688 no 2540 0.241067598560559 3693 2388925 SGTC_2763 lisinopril 49.32 µM -0.703073464438879 0.247887123366166 no 2541 0.2410049839943 3644 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_129 0088-0017 176.636 µM -0.704429246347617 0.247474481108788 no 2542 0.24058274898026 3599 182446 SGTC_356 1634-0012 32.5 µM -0.707163863448469 0.246643298218569 no 2543 0.23973232618897 3681 735457 SGTC_1178 0988-0033 191 µM -0.707691290569012 0.246483159682406 no 2544 0.239568493573647 3703 5392207 SGTC_3205 9113483 49.47 µM -0.708038792619116 0.246377680828768 no 2545 0.239460583786886 3707 17018033 SGTC_46 0329-0187a 2.197 µM -0.709077878137549 0.246062426925105 no 2546 0.239138075031872 3709 46494817 SGTC_3018 9082602 49.47 µM -0.710079116353376 0.245758860554018 no 2547 0.238827537939917 3683 17332089 SGTC_1474 0330-0125 5.35 µM -0.710221702405075 0.245715646114451 no 2548 0.238783332389625 3696 X1474 SGTC_1205 4161-2785 76 µM -0.713144604549974 0.244830683805064 no 2549 0.237878140347372 3729 3498106 SGTC_1169 aniline yellow 25.8 µM -0.71329530518467 0.244785102970849 no 2550 0.237831521009465 3655 6051 A DNA damaging agent. SGTC_1594 piperine 70.1 µM -0.714326122504339 0.244473445033639 no 2551 0.237512771404139 3695 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1834 st055981 52.8 µM -0.714395247908322 0.244452553268174 no 2552 0.237491404820776 3735 471719 YDL150W RPC53 SGTC_3190 9110366 49.47 µM -0.714808581271744 0.244327651632635 no 2553 0.237363665969187 3635 17123768 SGTC_1340 1486-1359 257 µM -0.716153785834639 0.243921394138979 no 2554 0.236948197743113 3665 4309068 SGTC_2420 aureobasidin a 50 nM -0.717216983414356 0.243600562010636 no 2555 0.236620110780027 3741 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1122 capsaicin 818.572 nM -0.717446635767139 0.243531291706425 no 2556 0.236549276316234 3777 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_468 gf-109203x 121 µM -0.718447594188957 0.243229495748908 no 2557 0.236240674860104 3643 2396 A protein kinase C inhibitor. SGTC_1949 st076024 69.1 µM -0.718457386087301 0.243226544422054 no 2558 0.236237657054878 3678 2921930 SGTC_1266 0828-0227 32.9 µM -0.71853854143792 0.243202084540947 no 2559 0.23621264627239 3708 3913820 SGTC_2793 7325131 81.82 µM -0.718885224310208 0.243097610758009 no 2560 0.236105820573014 3696 4176441 SGTC_1051 3253-3903 78 µM -0.719496105867053 0.242913579091328 no 2561 0.235917650359926 3713 5509239 SGTC_1316 1272-0050 65.9 µM -0.720027412992588 0.242753580998727 no 2562 0.235754058738213 3705 7340392 SGTC_1769 st044406 64.4 µM -0.720248875446348 0.242686906532539 no 2563 0.235685888024252 3721 670903 SGTC_970 1315-0089 19.5 µM -0.721312058247259 0.24236695810091 no 2564 0.235358769837158 3666 6811083 YLR033W RSC58 SGTC_3003 9075612 71.4286 µM -0.722184713514701 0.24210451686611 no 2565 0.235090460198817 3707 6501993 SGTC_102 gallobenzophenone 83.616 µM -0.723328279289411 0.241760835746093 no 2566 0.234739111386761 3735 70837 SGTC_2142 5622915 118.518 µM -0.723639151599829 0.241667453644392 no 2567 0.234643649280845 3716 5322196 SGTC_1384 3089-0840 101 µM -0.724953883871306 0.241272741336646 no 2568 0.234240161163707 3680 1069836 SGTC_2211 7117706 200 µM -0.726511401790184 0.240805593015298 no 2569 0.233762660170463 3653 822771 SGTC_2143 5623677 140.463 µM -0.727575183068504 0.240486814820379 no 2570 0.233436838387676 3672 5375313 SGTC_72 0744-0168 198.391 µM -0.727822957047937 0.240412598600044 no 2571 0.233360984765837 3645 677577 SGTC_1913 st060213 96.1 µM -0.72866305382635 0.240161055665947 no 2572 0.233103899034793 3730 688959 SGTC_1600 coumarin 106 71.1 µM -0.729674205726061 0.239858485505719 no 2573 0.232794675800776 3800 100336 A hepatotoxic, DNA x-linker. SGTC_2422 chlorphenesin carbamate 384.24 µM -0.732446853825983 0.23902988516182 no 2574 0.231947934935348 3749 2724 A muscle relaxant with antifungal properties. SGTC_738 1315-0003 72.4 µM -0.733247690741697 0.238790848242931 no 2575 0.231703686418738 3725 6251474 SGTC_2026 5148700 152 µM -0.73539521116271 0.238150493966549 no 2576 0.231049418751659 3732 79838 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.735841932222832 0.238017407624565 no 2577 0.230913449537352 3751 229346 A bile salt which induces apoptosis. SGTC_2242 6630449 61.2675 µM -0.736373115070759 0.23785921164975 no 2578 0.230751830713009 3802 691249 YDR170C SEC7 SGTC_2001 4023502 57.655 µM -0.736866858625892 0.237712217502313 no 2579 0.23060165992654 3753 108941 YCR052W RSC6 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.738176381534827 0.23732259625815 no 2580 0.230203636636057 3751 6708739 YPR165W RHO1 SGTC_3298 9116858 71.43 µM -0.738992152912354 0.23708005788079 no 2581 0.229955881170087 3755 2506942 SGTC_214 4373-3496 70 µM -0.73902106021202 0.237071465901775 no 2582 0.22994710456006 3809 3779166 SGTC_1015 4130-4525 82 µM -0.739116913329747 0.237042977160467 no 2583 0.229918003721824 3751 1363237 SGTC_2874 9043904 71.43 µM -0.739258452977873 0.23700091325329 no 2584 0.229875036302965 3719 4463428 SGTC_153 4077-0274 519.67 µM -0.740253721189189 0.236705247207649 no 2585 0.229573028101593 3793 3121976 SGTC_1962 st076595 64.5 µM -0.740825508063606 0.236535477297648 no 2586 0.229399623374531 3763 279619 SGTC_3030 9087619 49.47 µM -0.741175246067313 0.236431669212616 no 2587 0.229293595184926 3746 25236973 SGTC_2687 chenodiol 100 µM -0.742773030501987 0.235957739212115 no 2588 0.228809553113042 3761 5702181 A cholesterol synthesis inhibitor. SGTC_218 alverine citrate 93.75 µM -0.742922519939686 0.23591342490554 no 2589 0.22876429527836 3778 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1079 idarubicin 2.36 µM -0.743713445433735 0.235679041120443 no 2590 0.228524926728296 3709 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.74442901810395 0.235467098185185 no 2591 0.228308484510856 3791 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1489 4065-0444 182 µM -0.744731382073817 0.235377573692086 no 2592 0.228217061873812 3708 2877968 SGTC_2279 7948423 32.93 µM -0.744998455250683 0.235298513791696 no 2593 0.228136326865971 3719 1247112 SGTC_1744 st037937 38.9 µM -0.746091888842803 0.234974984827541 no 2594 0.227805954383889 3783 1016152 SGTC_3031 9088762 49.47 µM -0.747090829706998 0.234679629677527 no 2595 0.227504367634308 3723 205253 SGTC_236 1509-0011 5.31 µM -0.747452346221091 0.234572791314557 no 2596 0.227395278883994 3810 3107280 SGTC_1529 apigenin 74 µM -0.748673716850796 0.234212040774071 no 2597 0.227026944468258 3785 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_269 exalamide 29 µM -0.751016599442871 0.233520894974916 no 2598 0.226321332960846 3720 3316 A derivative of salicylamide. SGTC_637 1181-0519 7.26 µM -0.75114947143692 0.233481731919453 no 2599 0.226281352741421 3763 6252091 YGR060W ERG25 SGTC_27 0485-0001 32.618 µM -0.752883432678622 0.232970993543502 no 2600 0.225759982281066 3685 2054479 SGTC_489 paxilline 115 µM -0.752935845968625 0.232955564874011 no 2601 0.225744233150062 3716 105008 A toxic potassium channel blocker. SGTC_3282 9108498 15.4605 µM -0.753726913736522 0.232722770671413 no 2602 0.225506608813374 3765 16459645 SGTC_2748 diazoxide 86.69 µM -0.753867931754863 0.232681285688554 no 2603 0.225464264088164 3746 3019 A potassium channel activatior. SGTC_2923 7992654 58.14 µM -0.754415982466014 0.232520097990497 no 2604 0.225299738808046 3793 2985126 SGTC_2380 9035439 200 µM -0.755547869793485 0.232187394188191 no 2605 0.224960160591063 3860 6462575 SGTC_399 oxolinic acid 75 µM -0.758417748665425 0.231345018633704 no 2606 0.224100467945493 3745 4628 A DNA gyrase inhibitor. SGTC_612 0302-0167 22.4 µM -0.758741390066507 0.231250129492436 no 2607 0.224003636082866 3781 235821 SGTC_466 geldanamycin 89.2 µM -0.759240879752609 0.23110372562368 no 2608 0.223854237970122 3655 5288382 HSP90 inhibitor. SGTC_1227 3909-8010 46.6 µM -0.75972242110398 0.230962631520867 no 2609 0.223710261860286 3756 15982272 SGTC_2902 5787006 60.46 µM -0.760286490639356 0.230797417410781 no 2610 0.223541677613074 3729 591003 SGTC_1011 4112-3381 17.4 µM -0.762164783288561 0.230247747790985 no 2611 0.222980830889788 3857 2877139 SGTC_1235 benzylparaben 21.5 µM -0.762438076998645 0.230167831298625 no 2612 0.222899293897672 3774 7180 SGTC_3177 9107506 49.47 µM -0.763966652102716 0.22972113188964 no 2613 0.222443557859867 3688 8897194 SGTC_2186 6124449 200 µM -0.763977100015389 0.229718080340965 no 2614 0.222440444703354 3744 3834182 YLR033W RSC58 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.764319562380088 0.229618069047435 no 2615 0.222338415212624 3822 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_152 4469-0003 551.229 µM -0.764795765067866 0.229479041331056 no 2616 0.222196584975308 3724 697280 SGTC_1965 Pectolinarigenin 58.4 µM -0.764873491803018 0.229456353433906 no 2617 0.222173440068635 3772 5320438 An anti-inflammatory. SGTC_139 0099-0334 718.624 µM -0.766999690551138 0.228836218434206 no 2618 0.22154084975602 3825 97690 SGTC_2440 5628896 157.78 µM -0.767426833289069 0.228711749976636 no 2619 0.221413889815558 3813 5522048 SGTC_2665 lovastatin 100 µM -0.769254564053399 0.228179582778061 no 2620 0.220871102178186 3801 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1875 nocodazole 6 µM -0.772281981894383 0.227299644839226 no 2621 0.219973717352724 3757 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_791 1348-1292 225 µM -0.772596578741824 0.227208315096575 no 2622 0.219880584945521 3771 5437054 SGTC_394 menadione 8.33 µM -0.773493312345809 0.226948100369097 no 2623 0.21961524255232 3736 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2334 9017922 200 µM -0.774088601870776 0.226775451738236 no 2624 0.219439198700513 3848 3163164 SGTC_930 2810-3379 265 µM -0.776820708350921 0.22598402475589 no 2625 0.218632278663343 3810 1015764 SGTC_1171 0368-0077 21.4 µM -0.777526849217091 0.225779726590798 no 2626 0.218424000051775 3770 3239779 SGTC_459 nigericin 15.3 µM -0.780589980665463 0.224894722748784 no 2627 0.217521843264289 3835 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1524 corynanthine 62.1 µM -0.781990846501214 0.224490639040336 no 2628 0.217109976521043 3915 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2676 harmalol 100 µM -0.782087917494464 0.224462653909571 no 2629 0.217081453507074 3780 5459187 A monoamine oxidase inhibitor SGTC_1749 st037932 54.2 µM -0.784597378420186 0.223739875086154 no 2630 0.216344833804396 3842 594497 SGTC_2449 5812982 45.77 µM -0.78837711608147 0.222653730494515 no 2631 0.215238076104145 3777 776185 SGTC_2945 9067681 61.76 µM -0.790141748933122 0.222147676928873 no 2632 0.214722495257002 3900 16456930 SGTC_1105 epirubicin 18.1 µM -0.79016388431954 0.222141333212807 no 2633 0.214716032420856 3814 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_650 1328-0195 38 µM -0.79159115807613 0.221732513295435 no 2634 0.214299552084878 3753 2780821 SGTC_1148 3909-7663 27.7 µM -0.792350204352841 0.221515271739543 no 2635 0.214078252930905 3888 4084526 SGTC_2627 acetyl isogambogic acid 100 µM -0.793946682837405 0.221058751595089 no 2636 0.213613235571915 3820 6857789 A caspase activator and apoptosis inducer. SGTC_2768 sulfasalazine 50.2 µM -0.795880699875548 0.220506432669071 no 2637 0.213050690079146 3813 5384001 An antioxidant and salicylic acid derivative. SGTC_1878 temozolomide 1 mM -0.796128328538204 0.220435771727722 no 2638 0.212978725059077 3734 5394 DNA alkylating agent. SGTC_3033 9090887 49.47 µM -0.79944170440676 0.219491547921706 no 2639 0.212017168215719 3870 19325384 SGTC_380 3970-0968 6 µM -0.799550170600651 0.219460677272594 no 2640 0.211985733806216 3764 2891601 SGTC_2589 lobaric acid 100 µM -0.800325065342409 0.219240206445202 no 2641 0.211761242144592 3854 73157 A novel microtubule depolymerizer. SGTC_220 paclitaxel 373.376 µM -0.8008848470342 0.219081018200271 no 2642 0.211599156610227 3759 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2767 sibutramine 71.45 µM -0.801535397190815 0.218896101151743 no 2643 0.211410880222578 3824 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2737 bleomycin 30.5 nM -0.802255411346097 0.218691543880747 no 2644 0.211202614617764 3855 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1502 4534-4282 27.7 µM -0.80391042377601 0.218221769315906 no 2645 0.210724354799182 3812 3278949 SGTC_565 1418-0001 44.5 µM -0.804412153778008 0.21807946841639 no 2646 0.210579492170599 3902 2862145 SGTC_3068 9116768 49.47 µM -0.806075285141093 0.217608153007263 no 2647 0.210099720564461 3785 41904888 SGTC_1707 st032323 6.317 µM -0.806376153005709 0.217522952784575 no 2648 0.210012996388523 3725 3132057 YMR211W DML1 SGTC_10 0279-0212 42.575 µM -0.806732308236178 0.217422121092239 no 2649 0.209910363002674 3834 39851 YBR002C RER2 SGTC_924 2046-0044 21.3 µM -0.809444746307446 0.216655084145185 no 2650 0.209129686392048 3833 3623589 SGTC_1204 4049-0315 18.3 µM -0.810410965160395 0.21638223042855 no 2651 0.208852008924336 3962 588402 SGTC_1802 st050112 57.9 µM -0.811140154130616 0.216176444111281 no 2652 0.20864259435513 3849 4662563 SGTC_1448 4255-0083 152 µM -0.81323078855073 0.215587069367924 no 2653 0.208042875102113 3923 5399660 SGTC_1883 5-benzylidenerhodanine 20 µM -0.814721391223924 0.215167420343091 no 2654 0.207615902992549 3869 1273210 SGTC_1857 st056007 79.3 µM -0.815401490615503 0.214976109753539 no 2655 0.207421265690788 3857 619834 SGTC_2278 7948257 134.34 µM -0.81811406781981 0.214214050642687 no 2656 0.206646028380243 3859 1247028 SGTC_2932 9016711 44.54 µM -0.818925374778447 0.213986431448082 no 2657 0.206414495784219 3870 7117328 SGTC_3137 9097352 49.47 µM -0.819349602992495 0.213867466626419 no 2658 0.206293489811875 3890 44120435 SGTC_349 k015-0014 24 µM -0.819669277212916 0.2137778469611 no 2659 0.206202334386548 3852 2196908 SGTC_2988 9073640 71.4286 µM -0.821164213423635 0.213359036680147 no 2660 0.205776368853417 3898 9102229 SGTC_838 0109-0203 71.4 µM -0.821490144919494 0.21326778967326 no 2661 0.205683567657976 3869 759422 SGTC_3244 9134489 49.47 µM -0.822138873097698 0.213086241007658 no 2662 0.205498931769603 3883 16584271 SGTC_244 nsc-207895 1.295 µM -0.823594732740999 0.212679142351264 no 2663 0.205084934915139 3709 42640 SGTC_2569 tetrandrine 100 µM -0.824491212092006 0.212428687995308 no 2664 0.204830253526979 3882 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3264 9137442 49.47 µM -0.82573974997204 0.212080164389576 no 2665 0.204475869156203 3834 17015726 SGTC_2536 dehydroabietamide 32.04 µM -0.826000595651135 0.212007392765443 no 2666 0.204401876957898 3923 3983547 SGTC_882 0843-0131 351 µM -0.830034129463968 0.210883963792243 no 2667 0.203259743753584 3848 5425421 SGTC_69 0096-0274 206.684 µM -0.830971435384475 0.210623403949019 no 2668 0.202994883130257 3988 6741392 SGTC_532 1548-0774 215 µM -0.832406516062559 0.210224834894256 no 2669 0.202589762646977 4018 5932993 SGTC_2512 diallyl trisulfide 49.23 µM -0.833426644415913 0.209941781279199 no 2670 0.202302076484116 3905 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2623 humulene 100 µM -0.834889707289294 0.209536218430759 no 2671 0.201889905248164 3861 6187145 An anti-inflammatory. SGTC_426 0988-0037 14.6 µM -0.835186631554075 0.209453966947454 no 2672 0.201806317730473 3852 5383008 SGTC_2610 ononetin 44.17 µM -0.837602205838568 0.20878553091455 no 2673 0.201127076784537 3891 259632 SGTC_444 curcumin 90.4 µM -0.839065325001084 0.208381269604826 no 2674 0.200716326463845 3849 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1023 4482-3888 16 µM -0.840027564685856 0.208115653648657 no 2675 0.200446465760836 3889 3303168 SGTC_1804 st050076 49.1 µM -0.840796365438022 0.207903578112774 no 2676 0.200231011818925 3923 3895976 SGTC_1985 st071382 65.5 µM -0.840865978527814 0.207884381477119 no 2677 0.200211509847518 3895 6123237 SGTC_467 ro 31-8220 72.8 µM -0.841928879989074 0.207591403805692 no 2678 0.199913881869294 3833 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1133 3473-0247 50 µM -0.842962527952424 0.207306723696362 no 2679 0.199624700632664 3908 711311 SGTC_2781 5567276 71.43 µM -0.843557518447281 0.20714296030049 no 2680 0.199458355763302 3950 2853274 SGTC_2919 7978188 46.38 µM -0.843891036097582 0.207051197383538 no 2681 0.19936514884722 3862 2980291 SGTC_2515 chrysin 20.77 µM -0.843902250183693 0.207048112395848 no 2682 0.199362015344774 3918 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2586 curcumin 80 µM -0.844070569114509 0.207001811236619 no 2683 0.199314986293919 3892 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3246 9135460 32.98 µM -0.844155612716035 0.206978419778865 no 2684 0.199291227277535 3805 41446951 SGTC_697 0508-1955 564 µM -0.845260355609426 0.206674699609209 no 2685 0.198982745253046 3869 6243113 SGTC_1861 st057647 17.4 µM -0.845381998244719 0.206641273284779 no 2686 0.198948796061257 3985 688668 SGTC_1308 1187-1617 41.4 µM -0.845884351289266 0.206503265010102 no 2687 0.198808631540747 3881 2882570 SGTC_2245 6637752 200 µM -0.846277799135537 0.206395213710706 no 2688 0.198698894891999 3973 681890 SGTC_1026 k007-1105 30.6 µM -0.846590735453555 0.20630929695391 no 2689 0.198611639819734 3889 7066794 SGTC_1499 4480-0877 67.3 µM -0.847175939039323 0.20614868603316 no 2690 0.198448531329141 3824 2861909 SGTC_2955 9076254 12.21 µM -0.848780381796038 0.205708722199192 no 2691 0.198001754261727 3856 16459619 SGTC_736 0958-0254 92.6 µM -0.849255318241906 0.205578594010025 no 2692 0.197869618907733 4000 6812352 SGTC_3036 9090181 49.47 µM -0.849616133175832 0.205479766731939 no 2693 0.197769269706268 3917 25236586 SGTC_2058 5236698 133 µM -0.854290597028511 0.204201982251445 no 2694 0.196471997935637 3919 766665 SGTC_1717 st033143 58.0435 µM -0.854381160839904 0.204177273070191 no 2695 0.196446915413605 3921 674616 SGTC_2784 7567673 72.73 µM -0.856032925339735 0.203726922673828 no 2696 0.195989783828283 3887 3471247 SGTC_2570 licareol 100 µM -0.86265513613093 0.20192734511126 no 2697 0.194163553015076 3945 443158 SGTC_1218 1348-1416 30.7 µM -0.862791486040275 0.201890392455189 no 2698 0.194126060543484 3864 6787668 SGTC_1685 st024049 53.0905 µM -0.864271831161916 0.201489459691972 no 2699 0.193719290301211 3947 1941139 SGTC_2639 lactacystin 53 µM -0.864490728743291 0.201430214566252 no 2700 0.193659185608321 3955 3870 A proteasome inhibitor. SGTC_2238 6671620 73.2395 µM -0.864706939644573 0.201371706846331 no 2701 0.193599829785839 3870 729941 SGTC_1642 st009582 77.7 µM -0.864893722161819 0.201321170791743 no 2702 0.193548561795321 3869 6739311 SGTC_967 1306-0166 352 µM -0.865378096786145 0.201190153360861 no 2703 0.193415649428107 3864 4437607 SGTC_3161 9100388 49.47 µM -0.866161981565486 0.200978230438709 no 2704 0.193200669508962 3967 25236368 SGTC_1912 st060209 90.8 µM -0.867261477574629 0.200681207906427 no 2705 0.192899379277755 3971 688787 SGTC_3112 9123419 49.47 µM -0.867479165514203 0.200622432026879 no 2706 0.192839761226813 3956 17015854 SGTC_2751 anetholtrithion 17.25 µM -0.867485732061428 0.200620659215631 no 2707 0.192837963025805 3945 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1864 st057645 30.4 µM -0.867771316838985 0.200543567232129 no 2708 0.192759767630136 3968 688666 SGTC_817 1391-0715 46 µM -0.871058670985442 0.199657446284446 no 2709 0.191861059383811 3944 1353946 SGTC_710 3448-4187 58 µM -0.871715383006325 0.199480709380292 no 2710 0.191681833060169 3915 3946412 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.872599619866945 0.199242888923664 no 2711 0.19144067391379 3747 6708630 An antioxidant. SGTC_2324 6149169 200 µM -0.873198053457816 0.199082033789952 no 2712 0.191277567826189 3856 2888231 SGTC_212 3807-4682 38.772 µM -0.876694929780371 0.198143661077672 no 2713 0.190326180716195 4008 3125501 YBL034C STU1 SGTC_2082 5219693 150 µM -0.877957201384816 0.197805592578919 no 2714 0.189983472577877 3920 2834649 SGTC_2189 6047310 154.431 µM -0.878784482134243 0.197584214886854 no 2715 0.189759070842008 3899 711535 SGTC_875 0709-0210 25.7 µM -0.880749716651977 0.197058925213858 no 2716 0.189226650539107 3938 6251364 SGTC_537 1334-0398 209 µM -0.881186628257885 0.196942257575912 no 2717 0.189108407766678 3931 5846986 SGTC_455 paf C-16 10 µM -0.881257673647712 0.196923290419893 no 2718 0.189089184829836 3917 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_224 benfluorex 43.875 µM -0.881720104231912 0.196799861258299 no 2719 0.188964093189471 3944 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1400 3771-8998 51.5 µM -0.882596069893622 0.196566182287104 no 2720 0.188727276375455 3861 670767 SGTC_742 0kpi-0133 140 µM -0.883237583841347 0.196395154048104 no 2721 0.188553959541854 4012 2728852 SGTC_292 k038-0015 474 µM -0.884209113370323 0.196136315125641 no 2722 0.18829166983523 3940 46368540 SGTC_3132 9126706 49.47 µM -0.884468906873205 0.196067134937568 no 2723 0.188221569973642 4032 850858 SGTC_12 0849-0099 9.267 µM -0.884941156182221 0.195941417986402 no 2724 0.188094184589605 3847 6071388 SGTC_2306 7482397 179.52 µM -0.884997586317773 0.195926399056051 no 2725 0.188078966582466 3957 891448 SGTC_807 1315-0151 48 µM -0.885297478453866 0.195846594219574 no 2726 0.187998104804467 3953 4011080 SGTC_1179 1021-1431 9.29 µM -0.8859938960307 0.195661345392103 no 2727 0.18781040821601 3995 2840958 SGTC_2718 lomofungin 53.02 µM -0.886125717164982 0.195626292615995 no 2728 0.18777489317005 3910 5351222 A RNA synthesis inhibitor. SGTC_853 0419-0306 21 µM -0.886961517322245 0.195404132347301 no 2729 0.187549809723703 3966 762713 SGTC_2532 xanthone 78.9 µM -0.888278781913887 0.195054307444395 no 2730 0.187195405097298 3953 7020 An insecticide. SGTC_2084 5306078 60.6385 µM -0.889586564600234 0.194707377525872 no 2731 0.18684396151974 3900 679340 SGTC_3126 9127922 49.47 µM -0.891710548804986 0.194144725415334 no 2732 0.186274048958384 4008 45595682 SGTC_2760 etidronate 98.04 µM -0.894029861269146 0.193531462545303 no 2733 0.185652957163469 3931 3305 A chelator and antioxidant. SGTC_2289 7946404 165.07 µM -0.895648753437007 0.193104102901255 no 2734 0.185220194221763 3998 1246120 YPR165W RHO1 SGTC_506 n9-isopropylolomoucine 153 µM -0.897776896534159 0.192543187096062 no 2735 0.184652252064528 3965 6610355 SGTC_1715 st032160 10.2275 µM -0.897953788437331 0.192496608478557 no 2736 0.184605093331525 3914 5289825 SGTC_2650 prasterone 100 µM -0.898332140976547 0.192397005008791 no 2737 0.184504251075184 3933 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1442 4112-3290 3 µM -0.900594563420963 0.191802067235644 no 2738 0.183901963120269 3937 704353 SGTC_2783 7738165 71.43 µM -0.90065536624168 0.191786093783938 no 2739 0.183885793487149 3986 17201110 SGTC_3297 9117502 71.43 µM -0.901308798022663 0.191614482752907 no 2740 0.183712078622758 3979 7453720 SGTC_737 1950-0117 57.9 µM -0.902244444725897 0.191368917336479 no 2741 0.183463514991547 3915 5393513 SGTC_1248 0469-0687 58.6 µM -0.902273833641395 0.191361207185897 no 2742 0.183455710938119 3977 4017482 SGTC_2114 5491910 81.25 µM -0.905961421684744 0.190395283495152 no 2743 0.182478136053187 4034 2849228 SGTC_2319 6033012 152.6 µM -0.906716236068038 0.190197937869077 no 2744 0.182278437639827 3928 847246 SGTC_1113 artemisinin 1.17947 µM -0.906841964562109 0.190165078467918 no 2745 0.18224518739696 4013 2240 An anti-malaria and mitochondrial poison. SGTC_1496 4469-0713 57.4 µM -0.909939144766015 0.189356725713111 no 2746 0.181427302133619 3930 746691 SGTC_2256 7954252 200 µM -0.911668740052004 0.188906229405933 no 2747 0.18097156223173 4015 2972920 SGTC_515 4092-1064 102 µM -0.911827551524941 0.188864897952523 no 2748 0.180929752174262 4010 717353 SGTC_2770 toltrazuril 17.5 µM -0.912270776269799 0.188749576050233 no 2749 0.180813097088864 3900 68591 Kills coccidiodes. SGTC_3113 9123498 49.47 µM -0.912299598303652 0.188742078396805 no 2750 0.180805512870978 4047 8897275 SGTC_588 3970-1144 52.9 µM -0.913800452942213 0.188351905515063 no 2751 0.180410854202686 3885 1888707 SGTC_1139 k015-0024 46.9 µM -0.914204130172134 0.188247047670293 no 2752 0.180304797169961 4011 2766652 SGTC_473 2-arachidonoylglycerol 10 µM -0.91503800709212 0.188030556671812 no 2753 0.180085838842536 3835 5282280 An endocannabinoid. SGTC_2357 9067248 200 µM -0.916548791431055 0.187638718729954 no 2754 0.179689564442332 3990 9150235 SGTC_1701 st028638 40.4 µM -0.917620957446005 0.187360947381483 no 2755 0.179408671019263 3969 3490878 SGTC_605 1315-0399 119 µM -0.917681082348574 0.187345378056604 no 2756 0.179392927262707 4061 24020461 SGTC_3151 9099821 49.47 µM -0.918206365077408 0.187209390276852 no 2757 0.179255418482134 3972 17174189 SGTC_1929 genistein trimethyl ether 50.5 µM -0.919029501091774 0.186996415579529 no 2758 0.179040070883066 3963 136420 SGTC_2050 5263056 171 µM -0.921494351924835 0.186359567566022 no 2759 0.178396194347981 4023 763468 YGL055W OLE1 SGTC_2998 9066762 71.4286 µM -0.921503090826185 0.186357312073135 no 2760 0.178393914141506 4030 4945196 SGTC_863 0466-0191 129 µM -0.921558246857879 0.186343076802345 no 2761 0.178379522923086 4027 765160 YPR165W RHO1 SGTC_575 k072-0246 11.9 µM -0.923005093738809 0.185969899414178 no 2762 0.178002275367971 4043 6796779 SGTC_1678 st019265 80.2 µM -0.924215914404561 0.185657955408184 no 2763 0.177686955706983 4024 5367020 SGTC_2081 5214970 32.255 µM -0.924657418421606 0.185544291444617 no 2764 0.177572067791037 3922 2063512 SGTC_2157 5649910 96.377 µM -0.925287377655535 0.185382185006087 no 2765 0.177408221358023 3996 2858091 SGTC_1341 1486-1360 280 µM -0.926328578587913 0.185114447201335 no 2766 0.177137624170345 3987 3976547 SGTC_126 0417-1624 672.48 µM -0.92711353227038 0.184912760530863 no 2767 0.176933795412563 4047 41912 YDL195W SEC31 SGTC_1984 st072354 53.1 µM -0.928777297345987 0.184485722984501 no 2768 0.176502256133614 3885 5762938 SGTC_404 fumagillin 50 µM -0.931320952029888 0.183834031633654 no 2769 0.175843783526752 3990 12015870 A methionine aminopeptidase binder. SGTC_2320 7373003 200 µM -0.931491151613446 0.183790477271844 no 2770 0.175799779787237 4098 5415828 SGTC_1927 st060202 13.8 µM -0.934386068627185 0.18305064784221 no 2771 0.175052390696525 3893 688887 SGTC_1540 guanosine 70.6 µM -0.934497217404664 0.183022279578166 no 2772 0.175023735336383 3895 6802 Guanosine is a purine nucleoside SGTC_2394 5221648 200 µM -0.935463687380366 0.182775725156115 no 2773 0.174774694353724 4079 788586 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.937548105304354 0.18224467925997 no 2774 0.174238345540848 4065 279621 SGTC_665 3914-0008 307 µM -0.938976096533512 0.181881427962099 no 2775 0.17387150855378 3958 1069549 SGTC_1954 st077032 68.9 µM -0.939768009703431 0.18168017704211 no 2776 0.173668285677701 3996 698907 SGTC_1729 st035615 45.989 µM -0.940087679046559 0.181598978143543 no 2777 0.17358629410674 4059 17385451 SGTC_1077 5-fluorocytosine 377 nM -0.941735164318093 0.181180862237391 no 2778 0.173164123451519 4050 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1702 st027038 51 µM -0.942837154091967 0.180901524675567 no 2779 0.172882102160467 4046 5521182 SGTC_2247 cerulenin 830 nM -0.943605267685904 0.18070697934717 no 2780 0.172685699691152 4067 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1554 st069299 38.7 µM -0.94383221769882 0.180649523295599 no 2781 0.172627697039959 3993 24207999 SGTC_1711 st032263 62.8 µM -0.944655875400924 0.180441097323968 no 2782 0.172417295439507 4015 3958979 SGTC_2226 7298446 200 µM -0.945834996446298 0.180142984299269 no 2783 0.172116376309777 4015 3283010 SGTC_3301 9125354 19.7965 µM -0.946021947197693 0.18009574661026 no 2784 0.172068696103435 3996 41905162 SGTC_2513 baicalein 25.65 µM -0.948213513199424 0.179542573771609 no 2785 0.171510384583914 4045 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1692 fluoroquinolonic acid 71 µM -0.950431254294718 0.178983882450291 no 2786 0.170946584693334 4080 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1417 3966-0327 90.4 µM -0.952695376293844 0.178414636721418 no 2787 0.170372218362656 4123 651118 SGTC_830 4076-0286 57.8 µM -0.952962042448643 0.1783476666563 no 2788 0.170304651496902 4099 6866659 SGTC_1085 doxorubicin 7.67 µM -0.953673874246124 0.178168976065976 no 2789 0.170124374318946 4050 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2389 9091542 195.52 µM -0.95507461506998 0.177817678827621 no 2790 0.169769982584561 4025 3626624 YOL127W RPL25 SGTC_1350 1495-0454 146 µM -0.956977438461257 0.177341162776891 no 2791 0.169289321397329 4099 1069057 SGTC_874 0599-0792 117 µM -0.957331197320638 0.177252661400376 no 2792 0.16920005681765 4059 765305 SGTC_2907 7721985 69.9 µM -0.958413264725602 0.176982129117221 no 2793 0.168927204520854 4081 3267881 SGTC_2824 7998404 51.95 µM -0.959437349787101 0.176726333689911 no 2794 0.168669233447243 4008 837851 SGTC_603 3794-0023 45.9 µM -0.96052888103434 0.176453949059885 no 2795 0.168394551334509 4082 3802260 SGTC_2753 fluvastatin 17.09 µM -0.961440312820054 0.176226710666547 no 2796 0.168165411483487 4084 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1258 0671-0043 57.1 µM -0.965670983686569 0.175174345349053 no 2797 0.167104421681852 4080 4298767 SGTC_351 caspofungin 25 nM -0.969289513463772 0.174277417445293 no 2798 0.166200379971023 4056 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_486 niguldipine 82 µM -0.970321747770988 0.174022092590544 no 2799 0.165943070135175 4094 1236 A calcium channel blocker. SGTC_561 1550-0330 72.9 µM -0.970436635461954 0.173993689645727 no 2800 0.16591444747752 3993 6812934 SGTC_1783 st039459 87.517 µM -0.97058880664372 0.173956073880931 no 2801 0.165876541073138 4165 729761 SGTC_2095 5432005 200 µM -0.971345589188991 0.173769078777382 no 2802 0.165688106892925 4063 783734 SGTC_1942 st076330 65.2 µM -0.973464195833172 0.173246267800232 no 2803 0.165161323351199 4114 24208414 SGTC_1020 4335-0961 93.3 µM -0.97348867770096 0.173240232241762 no 2804 0.165155242370187 3985 669075 SGTC_1330 1469-0054 61.8 µM -0.974299766389057 0.173040348805559 no 2805 0.164953860311744 4060 7102664 SGTC_2201 6605497 169.863 µM -0.974720422741996 0.172936740787534 no 2806 0.1648494798259 3983 670741 SGTC_21 0849-0113 22.993 µM -0.974851336082486 0.172904504786813 no 2807 0.164817004087729 4013 1560156 SGTC_978 1416-0512 87.4 µM -0.976229430915198 0.17256539610063 no 2808 0.164475390850664 4140 6814003 SGTC_2366 9070441 60.58 µM -0.976829301417937 0.172417918148344 no 2809 0.164326833591465 4062 6837235 SGTC_307 1501-1223 22.3 µM -0.977675461048462 0.172210026824309 no 2810 0.164117431059997 4092 2830329 SGTC_1405 3909-7894 12 µM -0.978034520455362 0.17212185857143 no 2811 0.164028625511713 4070 7104060 SGTC_2291 7917025 104.35 µM -0.979954454675938 0.17165090123747 no 2812 0.16355430059679 3996 2964612 SGTC_1750 st081859 2.357 µM -0.98208794804232 0.171128524782171 no 2813 0.16302826117607 4024 5291695 SGTC_2584 androsterone 48.74 µM -0.982802588762615 0.170953775698867 no 2814 0.162852303754889 4028 2754130 A steroid. SGTC_1728 st035614 33.7865 µM -0.983481731595248 0.170787812650652 no 2815 0.162685201041202 4044 15945546 SGTC_1420 4'-methoxyflavone 42 µM -0.98370271496474 0.17073383288873 no 2816 0.162630852265703 4049 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2721 ifenprodil 61.44 µM -0.98394000600542 0.170675881800342 no 2817 0.162572505925254 4048 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3155 9099265 49.47 µM -0.984175422722124 0.170618400902265 no 2818 0.162514633913376 4101 25236499 SGTC_1455 4262-0120 131 µM -0.984183124867989 0.170616520504931 no 2819 0.16251274073704 4156 1529587 SGTC_2541 muurolladie-3-one 83.07 µM -0.986418034283971 0.170071451550793 no 2820 0.161964009472834 4097 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3331 9141060 1.957 µM -0.98676087150294 0.169987936297134 no 2821 0.161879940476499 4032 4906567 YPR165W RHO1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.987190847527423 0.169883231170568 no 2822 0.161774543890669 4129 23847180 SGTC_2516 gossypol 71.55 µM -0.991746669653743 0.168776366326962 no 2823 0.160660559377114 4127 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3247 9135149 49.47 µM -0.992496255969004 0.168594694708484 no 2824 0.160477752470137 4068 8934436 YOR116C RPO31 SGTC_2540 epiandrosterone 100 µM -0.995469035568096 0.167875442787778 no 2825 0.159754098455082 4116 441302 A steroid. SGTC_777 1315-0167 517 µM -0.996090732961933 0.167725275749809 no 2826 0.159603031047206 4098 4221767 SGTC_2708 st078559 56 µM -0.997516549127072 0.167381205744717 no 2827 0.159256922518358 4023 17250902 SGTC_1154 4088-0362 150 µM -0.997761377668708 0.167322170874161 no 2828 0.159197541308045 4076 6618304 SGTC_1635 st007035 42.4 µM -1.00068245617312 0.166618854154316 no 2829 0.15849017586529 4061 3716403 SGTC_1468 k284-1086 134 µM -1.00183082463591 0.166342881325461 no 2830 0.158212653500728 4069 15996457 SGTC_749 1000-0129 128 µM -1.00188369660019 0.166330182388667 no 2831 0.158199883794001 4151 708470 SGTC_471 1-acyl-paf 4 µM -1.00317858642272 0.166019367548045 no 2832 0.157887351434666 4016 16759367 SGTC_741 4582-0002 126 µM -1.00345498398427 0.165953071956733 no 2833 0.157820693142616 4066 2912688 SGTC_1751 st044839 27.194 µM -1.00520777131323 0.165533053869148 no 2834 0.157398406948588 4103 5291326 SGTC_119 0121-0043 24.815 µM -1.00607576676514 0.165325312056605 no 2835 0.157189562385447 4096 1092378 SGTC_2806 7952793 58.44 µM -1.00631497623997 0.165268090488543 no 2836 0.1571320392895 4172 2972490 SGTC_1631 benzylvanillin 81.9 µM -1.00830529880313 0.164792480232812 no 2837 0.156653959993826 4180 75506 SGTC_3035 9091303 49.47 µM -1.00957798015841 0.16448882370382 no 2838 0.156348761883065 4162 25237002 SGTC_189 3970-0742 2.116 µM -1.00961480866426 0.164480041976623 no 2839 0.156339935977707 4022 2891807 SGTC_511 blebbistatin 171 µM -1.01206080497199 0.163897476507116 no 2840 0.155754490684227 4160 3476986 A myosin inhibitor. SGTC_1478 0453-0656 35.7 µM -1.01260238674894 0.163768668689953 no 2841 0.155625059685413 4089 5258496 SGTC_3105 9121040 49.47 µM -1.01282987486214 0.163714583356001 no 2842 0.155570714149547 3973 41448907 SGTC_2329 6138490 200 µM -1.01347329860422 0.163561672046775 no 2843 0.155417071889483 4223 720019 SGTC_1486 3970-0793 4.53 µM -1.01407654272158 0.163418393791237 no 2844 0.155273115036126 4119 2844330 SGTC_247 mechlorethamine 29.705 µM -1.01440195388358 0.163341138304623 no 2845 0.155195496184028 3999 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1469 k284-2957 126 µM -1.01604868730058 0.162950553127478 no 2846 0.154803101138391 4084 23884841 SGTC_186 3455-3465 67.277 µM -1.01636734883336 0.162875040658549 no 2847 0.154727244015222 4056 755278 SGTC_3070 9117005 49.47 µM -1.01737573797522 0.162636235024044 no 2848 0.154487359642263 4194 8779016 SGTC_2473 5854593 8.94 µM -1.01877825307759 0.162304471815375 no 2849 0.154154126127122 3996 2872951 SGTC_303 1348-1668 34.2 µM -1.01956451687304 0.162118674946669 no 2850 0.153967520272055 4115 5380509 SGTC_190 3970-0790 3.722 µM -1.02134904808887 0.16169749814647 no 2851 0.15354454805957 4013 2832352 SGTC_2756 carbadox 75.1 µM -1.02646614091932 0.160493743642521 no 2852 0.152335957795005 4077 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2667 digitoxin 100 µM -1.02764062833213 0.160218283231948 no 2853 0.152059452704998 4043 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1798 st045719 60.953 µM -1.02889209918061 0.159925107672465 no 2854 0.151765190733396 4009 3980186 SGTC_2914 7968218 45.32 µM -1.02908067014171 0.159880962572331 no 2855 0.151720884323279 4079 2977111 SGTC_2426 5582046 32.21 µM -1.03306683651115 0.158949652816704 no 2856 0.150786310889598 4138 2251934 SGTC_151 3013-0144 2.285 µM -1.03559828326253 0.158360066488899 no 2857 0.150194796612637 4012 906558 YHR107C CDC12 SGTC_338 4055-0136 114 µM -1.0387487541837 0.157628312887607 no 2858 0.14946080011017 4085 2900563 SGTC_2830 7992007 71.43 µM -1.03912349447128 0.157541420781274 no 2859 0.149373652743833 4008 1952075 SGTC_2014 4013930 200 µM -1.0393218835809 0.157495432473516 no 2860 0.149327530291329 4086 64556 SGTC_1094 duloxetine 25.4 µM -1.03973049088894 0.157400741573362 no 2861 0.149232565264217 4137 60834 A selective serotonin reuptake inhibitor. SGTC_2506 ethyl hematommate 54.16 µM -1.04040000256416 0.15724566944597 no 2862 0.149077050260592 4202 3940691 An allergen. SGTC_1855 st056195 39.6 µM -1.04118774277639 0.15706334192186 no 2863 0.148894211644984 4092 4028379 SGTC_2629 bisabolol 100 µM -1.04521928880244 0.156132392423727 no 2864 0.147960815270255 4181 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.04672844253145 0.155784841481999 no 2865 0.147612420881106 4194 5393153 SGTC_1285 0929-0069 65.5 µM -1.04772784181286 0.155554965546065 no 2866 0.147382008086406 4168 1206237 SGTC_328 k915-0120 63.5 µM -1.04780456006165 0.155537328518811 no 2867 0.147364330561291 4122 6624543 SGTC_40 0327-0103 19.753 µM -1.04845815286924 0.155387125270422 no 2868 0.14721378642019 3998 409036 SGTC_3021 9087658 49.47 µM -1.05135494126622 0.154722562094293 no 2869 0.146547801134487 4141 25237042 SGTC_1447 4239-0816 81.9 µM -1.05270170430241 0.154414236534273 no 2870 0.146238863656396 4155 1341554 SGTC_2762 leflunomide 42.06 µM -1.05330282242527 0.154276748815908 no 2871 0.146101112885523 4117 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_3342 9147791 14.508 µM -1.056184092704 0.153618869040261 no 2872 0.145442058426508 4059 1838168 SGTC_3067 9117431 49.47 µM -1.05699271788436 0.1534345701494 no 2873 0.145257455451431 4179 17150885 SGTC_745 0469-0705 296 µM -1.06032423668291 0.152676807846918 no 2874 0.144498558338949 4223 3486736 SGTC_211 3455-0679 143.504 µM -1.06055405472547 0.152624626845464 no 2875 0.144446306047114 4206 748649 SGTC_2935 9038016 29.96 µM -1.06256832704682 0.152167785507665 no 2876 0.143988878417502 4141 6463195 SGTC_1149 3909-7961 23.3 µM -1.06293441577965 0.152084853396831 no 2877 0.143905847173372 4200 735261 SGTC_856 0433-0016 11.3 µM -1.06356214329282 0.151942720676116 no 2878 0.143763549779153 4200 3911780 SGTC_1776 st049249 45.9 µM -1.06366824895712 0.151918704503446 no 2879 0.143739506433871 4170 1822314 SGTC_3049 9092223 49.47 µM -1.0659180525254 0.15141007299225 no 2880 0.143230343812975 4141 8623917 SGTC_333 3486-0131 40.1 µM -1.06673673644413 0.151225267749788 no 2881 0.143045366628882 4193 6744690 SGTC_74 000s-0487 160.283 µM -1.06746854568158 0.151060200186313 no 2882 0.142880154988324 4047 677548 SGTC_1727 st034309 9.9045 µM -1.06819317933004 0.150896869334513 no 2883 0.142716690411873 4233 870305 SGTC_2041 5107442 45.335 µM -1.07084085431044 0.150301088873594 no 2884 0.142120496868133 4211 793005 SGTC_3041 9091929 49.47 µM -1.08500180699898 0.147141228194045 no 2885 0.138960427471411 4183 25236887 SGTC_3186 9110464 49.47 µM -1.0867837600074 0.146746783089532 no 2886 0.138566193267285 4187 17018021 SGTC_3119 9125183 49.47 µM -1.08806449146476 0.146463724709108 no 2887 0.138283319001215 3992 22695334 SGTC_913 3487-1245 167 µM -1.09003142174445 0.146029721550535 no 2888 0.137849651487245 4129 4016153 SGTC_1403 3909-7815 62.9 µM -1.09171075484461 0.145659861137466 no 2889 0.137480128240349 4135 6615483 SGTC_2077 5212015 200 µM -1.09194178952651 0.145609026822848 no 2890 0.137429343953119 4038 780900 SGTC_1140 3229-1848 2.98 µM -1.09340211641598 0.145287988663647 no 2891 0.13710864236069 4204 2849525 SGTC_2166 5933061 31.504 µM -1.09594245680009 0.144730655936221 no 2892 0.136551978724305 4333 2877375 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.09632922873281 0.144645927380166 no 2893 0.13646736133665 4232 6708784 An antioxidant flavonoid SGTC_668 1682-0499 62.6 µM -1.09756347672222 0.144375769160838 no 2894 0.136197574277651 4165 682214 SGTC_1981 st071826 47 µM -1.0980940447164 0.144259740428822 no 2895 0.13608171276805 4224 11838600 SGTC_2842 9000675 19.48 µM -1.09993711057024 0.143857172999792 no 2896 0.135679762019462 4249 2989072 SGTC_606 k015-0008 38.6 µM -1.10142984878732 0.143531681061031 no 2897 0.135354810218314 4278 1970475 SGTC_512 prima-1 270 µM -1.10184749873185 0.143440701459688 no 2898 0.135263988248651 4205 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3005 9076496 71.4286 µM -1.10434394520085 0.14289769511418 no 2899 0.134721983358141 4166 21368410 SGTC_3276 9139060 49.47 µM -1.10467926623145 0.142824864835338 no 2900 0.134649295315367 4282 4870619 SGTC_2572 astragaloside iv 100 µM -1.10610036127228 0.142516487648319 no 2901 0.134341541188672 4235 45006101 An anti-inflammatory agent. SGTC_1730 st033808 45.1 µM -1.10639830175932 0.142451891798722 no 2902 0.134277080121326 4133 1045166 SGTC_1211 1056-0033 32.3 µM -1.10705586756601 0.142309396436119 no 2903 0.134134887319481 4250 6741922 SGTC_1060 3448-7350 82 µM -1.11070235761718 0.141520947893237 no 2904 0.133348243547956 4154 570178 SGTC_2883 9059145 45.46 µM -1.11122485054182 0.141408216743613 no 2905 0.13323578858108 4202 16476510 SGTC_3135 9127742 49.47 µM -1.11129804703893 0.141392428998312 no 2906 0.13322003987782 4294 3643468 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.11269186571353 0.141092024341792 no 2907 0.132920395129205 4186 140250 A respiratory chain inhibitor. SGTC_2882 9058044 58.44 µM -1.11641168520475 0.14029242532154 no 2908 0.132122976977275 4243 18076804 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.11672385502153 0.140225462670992 no 2909 0.132056207436545 4232 94937 An inhibitor of serotonin biosynthesis. SGTC_2993 9054257 71.4286 µM -1.11877241735467 0.139786570168717 no 2910 0.13161862085468 4142 6470217 YGL055W OLE1 SGTC_638 3970-0837 4.09 µM -1.11974183301111 0.139579204384128 no 2911 0.131411896415551 4188 4118451 YLR208W SEC13 SGTC_2800 7887935 81.82 µM -1.11999253572054 0.139525611126759 no 2912 0.131358471457034 4211 2961002 SGTC_855 0428-0020 25 µM -1.12071669334519 0.139370884999871 no 2913 0.131204237087825 4237 6812414 SGTC_1690 st023502 41.2 µM -1.12101616454214 0.139306933036083 no 2914 0.13114049092862 4215 24207482 SGTC_2044 5102272 200 µM -1.12150002694115 0.139203646596504 no 2915 0.131037540028428 4209 592666 SGTC_905 2-aminofluorene 215 µM -1.12252995272092 0.13898396970458 no 2916 0.130818589746762 4229 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2829 7992743 58.44 µM -1.12345175735977 0.138787554646881 no 2917 0.130622839311497 4220 16462845 SGTC_1305 1181-0477 144 µM -1.12662475938452 0.138112907758723 no 2918 0.129950583145988 4277 6252086 SGTC_2266 7929956 200 µM -1.12891805369529 0.137626699676032 no 2919 0.129466202052502 4156 2967153 SGTC_1275 0867-0008 21.1 µM -1.13131722667616 0.137119295726759 no 2920 0.128960798128747 4188 3422836 SGTC_861 0443-0273 110 µM -1.13249830044991 0.136869979043683 no 2921 0.128712499251195 4219 6149169 SGTC_2872 9044037 25.97 µM -1.13289922106242 0.136785417898058 no 2922 0.128628288579007 4240 6465195 SGTC_1821 st053465 65.6 µM -1.13400448581353 0.1365524832654 no 2923 0.128396333179826 4223 675086 SGTC_799 1310-0557 151 µM -1.1362945000627 0.136070726300328 no 2924 0.127916665916049 4285 5354492 SGTC_3080 9117754 49.47 µM -1.13637813882798 0.136053153018961 no 2925 0.127899170507751 4236 9550191 SGTC_1660 st012960 28.1 µM -1.14008716902312 0.135275413086263 no 2926 0.127124993478428 4256 24207266 SGTC_735 3076-0345 636 µM -1.14042537459171 0.135204647291215 no 2927 0.127054563205266 4293 2888990 SGTC_669 0108-0021 26.2 µM -1.14450190402417 0.134353674867364 no 2928 0.126207774356352 4183 17201 SGTC_1296 1068-0102 11.9 µM -1.14469093644137 0.134314303919749 no 2929 0.126168603637304 4227 767053 SGTC_866 0495-0101 262 µM -1.14527742260062 0.134192203256772 no 2930 0.126047127705077 4211 635694 SGTC_2138 5575593 77.673 µM -1.14531356797696 0.134184680639156 no 2931 0.126039643763369 4242 762213 SGTC_1002 4049-0206 172 µM -1.14550066313374 0.134145746808552 no 2932 0.126000910448297 4192 4662749 SGTC_3076 9116187 49.47 µM -1.14716990829917 0.133798726354559 no 2933 0.125655702834174 4224 27241210 SGTC_2154 5570129 200 µM -1.1509505540761 0.133015048472471 no 2934 0.124876289060729 4294 673366 SGTC_812 4251-0442 148 µM -1.15104703658387 0.132995090357687 no 2935 0.124856442631986 4266 5723007 SGTC_1676 st018489 23.4 µM -1.15210907468658 0.13277553621749 no 2936 0.124638127287384 4268 3696235 SGTC_3210 9128157 49.47 µM -1.15377496723144 0.132431650900338 no 2937 0.124296219807167 4246 17590849 SGTC_1809 st050081 57.6 µM -1.15423741830237 0.132336297416967 no 2938 0.124201422871737 4320 5036894 SGTC_89 0302-0250 142.109 µM -1.15895235675666 0.131366817638209 no 2939 0.123237802844309 4347 4203518 YLR208W SEC13 SGTC_323 4013-0906 34.3 µM -1.16463644410313 0.130204596501536 no 2940 0.122083092647762 4271 2910086 SGTC_2994 9053520 71.4286 µM -1.16504998896137 0.130120317807136 no 2941 0.121999379369787 4295 4647384 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.16619929241492 0.129886292901746 no 2942 0.121766939299328 4192 1241132 A phosphatase inhibitor. SGTC_2731 amoxapine 43.43 µM -1.16739870781781 0.129642374951352 no 2943 0.121524696363921 4403 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1966 st070145 16.1 µM -1.16954113360455 0.12920747252121 no 2944 0.121092839340092 4244 3748532 SGTC_2029 5175081 200 µM -1.17109259373399 0.128893165401101 no 2945 0.120780780266397 4220 1380876 SGTC_828 2074-0507 139 µM -1.17137019009206 0.12883698370438 no 2946 0.120725004577561 4335 X828 SGTC_2223 6903751 107.57 µM -1.17484364265364 0.128135440401682 no 2947 0.120028638085999 4219 5598863 SGTC_598 3937-0236 20.2 µM -1.17916407765911 0.12726653809416 no 2948 0.119166423572767 4322 1379313 SGTC_618 k072-0232 33.2 µM -1.18116471513653 0.126865572436132 no 2949 0.118768647713687 4309 5872756 YGL099W LSG1 SGTC_751 0833-0568 350 µM -1.18136165319956 0.12682614991612 no 2950 0.118729542359603 4291 6954252 SGTC_3195 9113082 49.47 µM -1.18193951193103 0.126710524974512 no 2951 0.118614851325567 4266 17018038 SGTC_1602 st001878 87.6 µM -1.18247837441926 0.126602769031947 no 2952 0.118507970664659 4252 595405 YLR310C CDC25 SGTC_1098 clofazimine 15.1 µM -1.18392617356429 0.126313569847144 no 2953 0.118221144153436 4329 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_111 0083-0039 52.457 µM -1.18711459941269 0.125678303062797 no 2954 0.117591210214732 4178 759313 SGTC_1238 0333-0287 48.8 µM -1.18734458961655 0.125632565811824 no 2955 0.117545863345943 4253 7226 SGTC_1183 1254-0324 198 µM -1.18856078201565 0.125390899478868 no 2956 0.117306274102069 4345 5799357 SGTC_101 0490-5701 117.494 µM -1.19104440319226 0.124898394180891 no 2957 0.116818076915552 4114 4661669 SGTC_1581 himbacine 57.9 µM -1.19151385613138 0.124805453136245 no 2958 0.116725960188448 4270 5281825 An alkaloid muscarinic receptor antagonist. SGTC_559 1550-0661 158 µM -1.19176873335008 0.12475501346878 no 2959 0.116675969392162 4332 5830875 SGTC_1583 clindamycin 39.6 µM -1.1925268851538 0.124605061033413 no 2960 0.116527357685082 4243 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2043 5101342 149 µM -1.19660498748433 0.123800627812881 no 2961 0.115730277789868 4297 678451 SGTC_1116 jasmonic acid  1.58368 µM -1.19852347787768 0.123423452761628 no 2962 0.115356644282563 4336 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3249 9135183 49.47 µM -1.19865480307709 0.123397663707441 no 2963 0.115331099574139 4267 4902779 SGTC_552 k242-0005 476 µM -1.19967476654526 0.123197496364846 no 2964 0.115132838347949 4354 4088318 SGTC_1353 1498-1206 8.11 µM -1.20242770836943 0.122658369138792 no 2965 0.114598929599044 4314 6756808 SGTC_1860 st056228 74.6 µM -1.20526722622957 0.122104023293344 no 2966 0.114050078707428 4266 688679 SGTC_3181 9108277 49.47 µM -1.20532588760011 0.122092589684387 no 2967 0.114038759817567 4243 17097298 SGTC_2349 9023730 187.07 µM -1.20606822347126 0.121947966946547 no 2968 0.113895592989568 4320 4126287 SGTC_699 0375-0592 111 µM -1.20644268294202 0.1218750599916 no 2969 0.113823423387368 4360 762578 SGTC_3061 glucosamine 200 µM -1.20694317405775 0.121777662597502 no 2970 0.113727014594719 4223 91431 and experimental redox chemotherapeutic SGTC_92 0063-0024 660.874 µM -1.20728300642238 0.121711561162326 no 2971 0.113661586423814 4377 3594437 SGTC_287 k060-0039 29.6 µM -1.20830860963984 0.121512222021498 no 2972 0.113464289000489 4331 5861974 SGTC_3013 9080133 71.4286 µM -1.20859847890965 0.121455923831276 no 2973 0.113408570540416 4383 17050193 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.21022401853584 0.121140552501946 no 2974 0.113096472038028 4380 688664 SGTC_161 4065-0411 162.148 µM -1.21030478013551 0.121124898958631 no 2975 0.113080982061955 4282 1906281 YLR208W SEC13 SGTC_1 0258-0098 57.368 µM -1.21061215453605 0.121065335408972 no 2976 0.113022041873877 4239 6790032 YDR047W HEM12 SGTC_1879 gemcitabine 100 µM -1.21344583858953 0.120517189675943 no 2977 0.112479704966208 4263 60750 A nucleoside analog which inhibits DNA replication. SGTC_2884 9058502 51.95 µM -1.21585266867338 0.120052988783396 no 2978 0.112020525549548 4327 6471554 SGTC_3045 9092950 49.47 µM -1.21771665483519 0.119694352100927 no 2979 0.111665832895542 4284 44120432 SGTC_1871 st057448 67.3 µM -1.2189257038069 0.119462131722999 no 2980 0.111436196400107 4334 691747 SGTC_1351 1496-0003 46.5 µM -1.21980737901471 0.119292990111364 no 2981 0.111268951727692 4319 3891978 SGTC_2285 7945142 200 µM -1.22051161081906 0.119158010917045 no 2982 0.111135495378786 4341 2970608 SGTC_1757 st041620 31.8375 µM -1.22360016796381 0.118567304565046 no 2983 0.110551548112143 4364 5289815 SGTC_2135 5326629 150.42 µM -1.22669461553631 0.117977549916969 no 2984 0.109968696120868 4252 5020077 SGTC_1416 3966-0321 25.3 µM -1.22786697124633 0.117754659670281 no 2985 0.109748455021213 4345 582530 YLR208W SEC13 SGTC_2229 7354935 190 µM -1.23050035272638 0.117255083663097 no 2986 0.109254897499806 4252 318112 SGTC_514 4466-0038 2.65 nM -1.23125904258805 0.117111432383756 no 2987 0.109112997562324 4113 5722064 SGTC_2277 7947813 106.88 µM -1.23143906441327 0.117077365139102 no 2988 0.109079347015157 4342 1246798 SGTC_2969 9091408 28.7 µM -1.23143923320725 0.117077333199905 no 2989 0.109079315466874 4269 4286311 SGTC_3273 9137859 49.47 µM -1.23823892480625 0.115795701140639 no 2990 0.107813741231215 4419 2377234 SGTC_142 0335-0849 62.6745 µM -1.24247107724196 0.115003056854781 no 2991 0.107031402664161 4297 3889043 YPR107C YTH1 SGTC_3327 9140648 26.9345 µM -1.24286651965756 0.114929191626253 no 2992 0.106958512494965 4345 8029710 SGTC_51 1013-0126 23.419 µM -1.24502035378366 0.114527466425561 no 2993 0.106562134304042 4337 1627850 SGTC_2803 7707263 71.43 µM -1.24796123848435 0.113980558971235 no 2994 0.106022626231502 4296 2199229 SGTC_200 k038-0079 37.545 µM -1.25113256859474 0.113392884241557 no 2995 0.105443057452802 4305 3436683 SGTC_371 0195-0006 7.36 µM -1.25394659810842 0.112873232685167 no 2996 0.104930708123423 4165 3928593 SGTC_3315 9136395 68.55 µM -1.25476672808475 0.11272210416549 no 2997 0.104781727090927 4316 16876844 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.25525445510598 0.112632297365911 no 2998 0.104693201511209 4434 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_276 colchicine 750 µM -1.26054738776983 0.111660977115744 no 2999 0.10373598219811 4389 2833 A microtubule depolymerizer. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.26151397404903 0.111484245333847 no 3000 0.1035618642617 4379 6710655 SGTC_423 5-fluorouracil 457 µM -1.2619824757787 0.111398655985949 no 3001 0.103477546126038 4267 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2474 5321570 43.32 µM -1.26210603703769 0.111376090744342 no 3002 0.103455316616339 4316 2841384 SGTC_60 0986-0278 202 µM -1.26821315536296 0.110264859028623 no 3003 0.10236092016243 4291 3110598 SGTC_1185 1319-0113 81.3 µM -1.27045146299604 0.109859581563363 no 3004 0.101961930831433 4403 4672763 SGTC_1845 st056753 3.01 µM -1.27224167903082 0.109536207769777 no 3005 0.1016436315494 4321 5375839 SGTC_1318 1280-3875 124 µM -1.27498300629156 0.1090423566504 no 3006 0.101157628476985 4348 373245 SGTC_374 0880-0231 82.3 µM -1.27554905386423 0.108940582617834 no 3007 0.10105748660737 4220 6833587 SGTC_67 0335-0847 266 µM -1.27685252099052 0.108706481978615 no 3008 0.100827159547132 4428 4552207 YOR254C SEC63 SGTC_1666 st014829 29 µM -1.2790601780726 0.108310815897218 no 3009 0.100437932645587 4331 3858230 SGTC_2437 5741531 144.16 µM -1.2804231672173 0.108067052990326 no 3010 0.10019817523829 4369 2262990 SGTC_2876 9059903 25.97 µM -1.28111724573208 0.107943072860876 no 3011 0.100076243616979 4337 6916095 SGTC_431 k089-0097 107 µM -1.28417238110078 0.107398565441914 no 3012 0.0995408233200638 4105 5499420 SGTC_1695 st026914 34.495 µM -1.28454602860998 0.107332107511107 no 3013 0.0994754845847019 4341 3289191 SGTC_376 3970-0862 59.1 µM -1.28594510509146 0.107083527417278 no 3014 0.0992311102817782 4382 3135186 SGTC_2664 lyso-paf C-16 73.48 µM -1.28613630449204 0.10704958845101 no 3015 0.0991977479328614 4314 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3059 1327-0034 3 µM -1.28705121227721 0.106887294568333 no 3016 0.099038219364358 4204 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2463 5473429 200 µM -1.28814433902457 0.106693619581001 no 3017 0.0988478616654846 4343 5399405 SGTC_2028 5153890 36.43 µM -1.293487402829 0.105750605094942 no 3018 0.0979212690842534 4349 2830968 YPR165W RHO1 SGTC_2061 5245884 80.95 µM -1.29350917881156 0.105746774150018 no 3019 0.0979175057693304 4334 573863 SGTC_507 nimesulide 162 µM -1.29617451859225 0.105278630983226 no 3020 0.0974576831585297 4412 4495 A COX2 inhibitor. SGTC_1705 st027868 56.3335 µM -1.29650695748474 0.105220346395286 no 3021 0.0974004423043931 4296 292948 SGTC_994 3910-0338 138 µM -1.29675413777663 0.105177024841279 no 3022 0.0973578976559081 4435 3479481 SGTC_3248 9135562 49.47 µM -1.2971278132209 0.105111557877712 no 3023 0.0972936065597389 4330 17650701 SGTC_246 cycloheximide 667 µM -1.29786061363214 0.104983258792182 no 3024 0.0971676182352723 4267 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2109 5483026 200 µM -1.2991830685914 0.10475200963453 no 3025 0.0969405553204789 4371 759335 SGTC_2033 5192550 145 µM -1.3006351426069 0.104498519966347 no 3026 0.0966916860215063 4364 182073 SGTC_834 0312-0008 75.7 µM -1.30112447237826 0.10441319749309 no 3027 0.0966079261545496 4383 6385573 YIL048W NEO1 SGTC_1322 1348-1070 12 µM -1.30380343683821 0.103946971802641 no 3028 0.0961503052592569 4365 6758089 SGTC_2156 5649887 115 µM -1.30403518032402 0.103906712068613 no 3029 0.0961107938377533 4388 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2375 9072683 200 µM -1.30415594599477 0.103885736484674 no 3030 0.0960902084619572 4422 16798029 SGTC_145 3737-0113 38.366 µM -1.30559196892602 0.103636551448841 no 3031 0.0958456764513533 4339 6849351 SGTC_597 k018-0003 82.8 µM -1.31714120195978 0.101648233935984 no 3032 0.093895649221362 4439 6786234 SGTC_2475 5812728 15.03 µM -1.31716748457172 0.10164374101845 no 3033 0.0938912451859392 4337 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_3015 9080845 49.47 µM -1.31770445921609 0.10155197879791 no 3034 0.0938013006168279 4427 5296973 SGTC_2726 cimetidine 79.27 µM -1.32205777259634 0.100810278588359 no 3035 0.0930744568861808 4360 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2982 9019404 25.97 µM -1.32244030282585 0.100745293906775 no 3036 0.0930107878794249 4320 22333232 SGTC_131 0141-0277 33.849 µM -1.32468764312062 0.100364129999288 no 3037 0.0926373866459378 4349 1547771 SGTC_1508 1080-0625 72.9 µM -1.3253438598912 0.100253030026632 no 3038 0.0925285640183657 4294 767111 SGTC_672 1441-0018 53.7 µM -1.32613827673617 0.100118652410019 no 3039 0.0923969497923124 4388 251141 SGTC_2441 5730946 39.09 µM -1.32947588908641 0.0995555235978114 no 3040 0.0918455076291086 4440 1774275 SGTC_959 1222-0044 107 µM -1.33301317205801 0.0989612362919642 no 3041 0.0912637406089488 4372 6083612 SGTC_99 0109-0120 622.8 µM -1.33764501359823 0.0981869854751064 no 3042 0.0905060917113032 4401 759414 SGTC_2296 7971656 126.45 µM -1.34109535344746 0.0976131230742536 no 3043 0.0899447478683587 4396 666570 SGTC_1430 4049-0248 69.1 µM -1.34301984174733 0.0972941115450715 no 3044 0.0896327745438051 4428 22774488 SGTC_2551 apiole 73.87 µM -1.34322087847932 0.0972608310022503 no 3045 0.089600231522226 4306 10659 A possible DNA adduct former. SGTC_2722 naftopidil 47.16 µM -1.34490178069384 0.0969828935773817 no 3046 0.0893284775634539 4326 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3230 9131665 49.47 µM -1.3465306792304 0.0967141116699784 no 3047 0.0890657165850454 4401 15943720 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.34800592468003 0.096471156284937 no 3048 0.0888282385195395 4431 165521 SGTC_2308 7584454 197.62 µM -1.34814414260659 0.0964484164320383 no 3049 0.0888060130271307 4426 893577 SGTC_2073 5212005 126 µM -1.34890166635177 0.0963238572537812 no 3050 0.0886842764680609 4297 691789 SGTC_2849 9019321 12.99 µM -1.34956811235728 0.0962143717265605 no 3051 0.088577279209522 4413 16489627 SGTC_1014 4130-3005 69.3 µM -1.35042273553647 0.096074105855374 no 3052 0.088440211050232 4417 743608 SGTC_175 3793-3120 23.7 µM -1.35160835218348 0.0958797644088418 no 3053 0.0882503185145072 4394 5322297 SGTC_1386 3228-0095 33.8 µM -1.35343532421687 0.0955808609053288 no 3054 0.0879582994266235 4399 870181 SGTC_646 4092-0839 27.3 µM -1.36160190478674 0.0942531406020013 no 3055 0.0866617768997621 4433 877796 SGTC_623 k072-0108 16.9 µM -1.36369453742627 0.0939151209510043 no 3056 0.0863318620057355 4383 5382803 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.36395971696183 0.0938723508693594 no 3057 0.0862901221543088 4434 5106787 A p450 inhibitor. SGTC_546 peri-Naphthalide 147 µM -1.36631831802075 0.0934925709866078 no 3058 0.0859195369649688 4362 223824 A penicillin ester. SGTC_1025 k007-0731 70 µM -1.36762290831373 0.0932829950376477 no 3059 0.085715071002592 4376 6256118 SGTC_1774 st048371 48.465 µM -1.37193294818672 0.0925930762823988 no 3060 0.085042156156346 4407 4242727 SGTC_567 1080-0542 68.4 µM -1.3724269995695 0.0925142340213743 no 3061 0.0849652749034799 4305 5950415 SGTC_1765 st044815 90.4 µM -1.37277871178767 0.092458136960345 no 3062 0.0849105753552231 4440 645695 SGTC_2307 7538926 6.34 µM -1.37350558492715 0.0923422826007801 no 3063 0.0847976130964076 4397 96582 SGTC_3058 9093861 49.47 µM -1.37542159210354 0.0920374102488102 no 3064 0.0845003893444486 4430 17217477 SGTC_3164 9100705 49.47 µM -1.37607050793486 0.091934324817238 no 3065 0.0843999025918492 4428 17174235 SGTC_2893 9048488 25.97 µM -1.37689581322856 0.0918033420806775 no 3066 0.0842722309184005 4446 6467338 SGTC_1373 2887-0003 58.5 µM -1.38278943914031 0.0908719911904156 no 3067 0.083364719062398 4379 776948 SGTC_912 3474-0017 2.18 µM -1.38607091558776 0.0903564776917534 no 3068 0.0828626251610974 4439 3360550 SGTC_2900 5328528 85.29 µM -1.39033400035153 0.0896900030013059 no 3069 0.0822137389077547 4425 795359 SGTC_1241 0364-0022 50.8 µM -1.39054573642563 0.0896569965042436 no 3070 0.0821816105030599 4420 4563895 SGTC_1198 1612-1005 86.7 µM -1.39248183195067 0.0893556068227174 no 3071 0.081888269749325 4497 6998509 SGTC_344 k064-0035 6.43 µM -1.39298962667748 0.0892766839253559 no 3072 0.081811463780526 4378 5088750 SGTC_2405 ticlatone 3.52 µM -1.3945351161366 0.0890367987079796 no 3073 0.0815780364692718 4231 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_118 0083-0097 135.343 µM -1.39470105458992 0.0890110708972085 no 3074 0.0815530033774524 4411 5207356 SGTC_1746 st038117 42 µM -1.39736638958963 0.0885985838636438 no 3075 0.0811517104298569 4464 2898218 SGTC_1371 2421-0008 32.7 µM -1.3985181389695 0.0884207804494738 no 3076 0.0809787647600529 4428 2827552 SGTC_1620 st003704 16.5 µM -1.40227014609121 0.0878434013385917 no 3077 0.0804172958733742 4428 2834414 SGTC_2178 5812956 200 µM -1.40386669089547 0.0875985710646944 no 3078 0.0801792750526222 4407 5403383 SGTC_1621 st003705 32.4 µM -1.41019132975348 0.0866336897995941 no 3079 0.0792415976248887 4440 24207032 SGTC_2696 st077691 74.316 µM -1.41047452838354 0.086590671825442 no 3080 0.0791998062277133 4458 757133 SGTC_823 0417-1665 178 µM -1.41482814314447 0.0859313642074565 no 3081 0.0785594452062347 4455 3429856 SGTC_418 lividomycin a 100 µM -1.41657807098302 0.085667417728425 no 3082 0.0783031618270489 4457 72394 An antibiotic. SGTC_2834 9001755 58.44 µM -1.41719679532745 0.0855742392092991 no 3083 0.0782126992426441 4323 2989575 SGTC_2462 5162487 171.77 µM -1.41739925267426 0.0855437660652736 no 3084 0.0781831155331346 4405 2259986 SGTC_961 1252-1571 372 µM -1.41793536784756 0.0854631112086211 no 3085 0.0781048176794536 4466 6813498 SGTC_1369 1866-0067 208 µM -1.41870110975748 0.0853480093708864 no 3086 0.0779930867730477 4459 3531355 SGTC_1101 ebselen 5.29 µM -1.41947213850196 0.0852322302173563 no 3087 0.0778807070272755 4452 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1245 0418-0076 17.2 µM -1.42159057157409 0.0849147281239836 no 3088 0.0775725717281867 4461 6790114 SGTC_100 0086-0128 49.5915 µM -1.42174141383508 0.0848921543624346 no 3089 0.0775506664190891 4454 93297 SGTC_1048 3161-0300 24.5 µM -1.4219568690614 0.0848599189803402 no 3090 0.0775193861630916 4455 2165101 SGTC_2097 5376186 200 µM -1.42662554838479 0.0841636655603667 no 3091 0.0768439280222079 4427 742755 SGTC_3253 9135987 49.47 µM -1.42988598779999 0.0836799759476686 no 3092 0.0763748721400439 4460 4182430 SGTC_1434 4073-0095 163 µM -1.43843253050361 0.0824220023249574 no 3093 0.0751556840565368 4457 24133745 SGTC_1488 4013-0813 75.9 µM -1.43886911508874 0.0823581253827546 no 3094 0.07509380476868 4440 2910057 SGTC_3180 9109287 49.47 µM -1.44102823132279 0.0820427717756429 no 3095 0.074788353622774 4488 18891271 SGTC_2105 5350118 200 µM -1.44301042994249 0.0817540599665436 no 3096 0.0745087665735981 4429 2133313 SGTC_3319 9138450 16.7555 µM -1.44378219580599 0.0816418578577033 no 3097 0.0744001258576284 4393 2029690 SGTC_1881 5652484 16 µM -1.44687647753281 0.0811931656931388 no 3098 0.0739657611426215 4463 2255129 SGTC_1267 0828-0272 9.49 µM -1.4486266434777 0.0809402047535146 no 3099 0.0737209382151381 4518 745334 SGTC_2978 9011784 42.97 µM -1.45080769675408 0.0806257985408232 no 3100 0.0734167079268473 4444 2994934 SGTC_1740 st038286 13.222 µM -1.45578922055318 0.079911155493071 no 3101 0.0727254482728993 4483 716786 SGTC_2128 5255449 168.493 µM -1.45938436377649 0.079398384171305 no 3102 0.0722296735910643 4398 736008 SGTC_652 0437-0092 114 µM -1.45946392206621 0.0793870650916574 no 3103 0.0722187317725464 4431 3091274 SGTC_2310 7668677 200 µM -1.46167431824076 0.0790730712374517 no 3104 0.0719152390405024 4451 2197143 SGTC_2634 4'-methoxyflavone 100 µM -1.46318395029957 0.0788591642997236 no 3105 0.0717085256350945 4459 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3237 9133362 49.47 µM -1.46420346454108 0.0787149526752882 no 3106 0.0715691819493463 4446 43845137 SGTC_3047 9092122 49.47 µM -1.46487754695 0.0786197126423244 no 3107 0.0714771648507716 4464 17173831 SGTC_3320 9137005 35.139 µM -1.47090667969996 0.0777717464863675 no 3108 0.0706581779870205 4525 4908713 SGTC_763 3453-1109 128 µM -1.47186567040571 0.0776375117612519 no 3109 0.0705285777961619 4514 1560353 SGTC_3329 9141233 27.5565 µM -1.47377857890856 0.0773702778740261 no 3110 0.0702706088332801 4443 4909101 YNL103W MET4 SGTC_675 1309-0189 238 µM -1.47593563236816 0.0770697756323762 no 3111 0.0699805863687356 4492 4246530 SGTC_1243 0416-0003 5.65 µM -1.47802126223742 0.0767800677229476 no 3112 0.0697010436283493 4471 2141977 SGTC_3185 9108267 49.47 µM -1.48250111314194 0.0761605869312927 no 3113 0.0691035038145313 4477 4910486 SGTC_2712 st079126 47.7 µM -1.48363744143072 0.0760040602075396 no 3114 0.0689525654102626 4488 3152970 SGTC_496 calpeptin 138 µM -1.48902939030534 0.0752646678716264 no 3115 0.0682398147951168 4482 73364 A calpain inhibitor. SGTC_883 0850-0245 24.6 µM -1.49401172895712 0.0745863313390672 no 3116 0.0675862768393437 4544 6823229 YPR165W RHO1 SGTC_1129 3453-1384 223 µM -1.49747171361755 0.0741180128900058 no 3117 0.0671352802079926 4493 1084452 SGTC_1170 0310-0127 64.8 µM -1.50226854001422 0.0734724692007027 no 3118 0.0665138850051291 4497 774975 SGTC_2867 9039098 71.43 µM -1.5040330772533 0.0732360874153053 no 3119 0.0662864250501239 4476 6463460 SGTC_1208 2323-2347 50.3 µM -1.50535029144678 0.0730600097417702 no 3120 0.0661170208880121 4504 5412760 SGTC_1891 st059073 26.2 µM -1.50894531777712 0.0725810958786999 no 3121 0.0656563787384521 4561 688754 SGTC_2878 9043973 25.97 µM -1.51552852141547 0.0717103479595794 no 3122 0.0648193065436328 4518 6465167 SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.52192613673457 0.070871846986735 no 3123 0.0640137946738522 4554 1273210 SGTC_491 tetrandrine 80.3 µM -1.52407476223282 0.0705919342321727 no 3124 0.063745018181818 4523 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1331 1472-0049 76.2 µM -1.5242237385042 0.0705725578540275 no 3125 0.0637264149924001 4481 24051409 SGTC_731 3966-0296 387 µM -1.52517905435072 0.0704484032557848 no 3126 0.0636072217146676 4506 660956 SGTC_410 α-linolenic acid 100 µM -1.52569329452535 0.0703816412191676 no 3127 0.063543132624938 4534 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1943 st076331 65.2 µM -1.52715213622733 0.0701925095552787 no 3128 0.0633615925411308 4500 24208415 SGTC_1557 sumaresinolic acid 42.3 µM -1.52819006204781 0.0700581857390918 no 3129 0.0632326777528192 4480 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_271 rotenone 740 µM -1.52904695267362 0.0699474398004607 no 3130 0.0631264022800138 4533 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3217 9129673 49.47 µM -1.52940951509666 0.0699006222188896 no 3131 0.0630814775402736 4485 17248312 SGTC_1407 3909-7909 12.3 µM -1.53023175844262 0.0697945355311337 no 3132 0.0629796864776511 4533 4411780 SGTC_1953 st076800 12.1 µM -1.53317165134958 0.0694162409457652 no 3133 0.0626167835692074 4479 297591 SGTC_2196 6573537 42.6665 µM -1.54174023172361 0.0683226745195902 no 3134 0.0615683656115298 4540 2903087 SGTC_2200 6600604 21.907 µM -1.54274340878965 0.068195518079953 no 3135 0.0614465225400567 4549 2904777 SGTC_2121 5257820 149.641 µM -1.5432170085856 0.0681355510443591 no 3136 0.0613890659233937 4543 791256 SGTC_1181 1222-0449 220 µM -1.5445447382688 0.067967651400231 no 3137 0.0612282109375163 4553 658318 SGTC_2891 9063876 19.48 µM -1.54966154578498 0.0673235859875513 no 3138 0.0606113862093388 4546 6472478 SGTC_3154 9100113 49.47 µM -1.55065255163084 0.0671993927275819 no 3139 0.0604924855297108 4509 25237525 SGTC_1560 lithocholic acid 53.1 µM -1.55540564043062 0.0666061944863233 no 3140 0.0599247458129112 4462 9903 A bile acid which acts as a detergent. SGTC_311 1315-0136 58 µM -1.56434168966698 0.0655019338575228 no 3141 0.0588686732671935 4559 6759207 SGTC_1335 1486-0900 202 µM -1.56581598073595 0.0653211225437042 no 3142 0.0586958519452049 4523 X1335 SGTC_609 0986-0026 86.3 µM -1.56612461403298 0.0652833199225895 no 3143 0.0586597233805334 4514 2848610 SGTC_185 k048-0037 25.491 µM -1.56750013587074 0.0651150469442166 no 3144 0.0584989172423479 4579 6827589 SGTC_2335 9018011 154.17 µM -1.56802415344533 0.0650510304314593 no 3145 0.0584377478074235 4504 6458208 SGTC_708 3448-5400 146 µM -1.5682048409508 0.0650289681036308 no 3146 0.0584166675068836 4492 3462195 SGTC_2221 6807166 181.081 µM -1.57163488405067 0.0646112532154527 no 3147 0.0580176257349029 4520 674925 SGTC_1497 4476-2978 41.3 µM -1.57301336296142 0.064443968613909 no 3148 0.0578578620202438 4577 1528379 SGTC_1955 wogonin 32.4 µM -1.57391028421389 0.0643353040333653 no 3149 0.0577540960030864 4509 5281703 A flavanone. SGTC_1558 st069300 45.6 µM -1.5813529491871 0.0634390889259344 no 3150 0.0568986795728298 4498 24208000 SGTC_1836 st055642 81 µM -1.58788604269821 0.062660436047882 no 3151 0.0561560550761643 4527 8571 SGTC_3083 9117465 49.47 µM -1.58885412781095 0.0625456903224207 no 3152 0.0560466648252171 4498 16420915 SGTC_1530 rhein 70.4 µM -1.58889536271804 0.0625408064483076 no 3153 0.0560420091584097 4621 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_945 3381-0768 11.3 µM -1.5919805072746 0.0621762435726895 no 3154 0.0556945422426729 4546 1126236 YIL048W NEO1 SGTC_2738 aclarubicin 5.55 µM -1.59571149812329 0.0617375799312436 no 3155 0.0552766101588231 4589 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3117 9124945 49.47 µM -1.59733708790773 0.061547211834878 no 3156 0.0550952939165764 4469 17592065 SGTC_401 neomycin 50 µM -1.60141193776664 0.061072032757594 no 3157 0.0546428552053811 4551 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3203 9113543 49.47 µM -1.60318224964169 0.0608664875834838 no 3158 0.054447211594188 4545 17018012 SGTC_2216 7189485 200 µM -1.61395681627723 0.0596271300575843 no 3159 0.0532683967195979 4576 731273 SGTC_2400 5203494 178.7 µM -1.61832657689433 0.0591301651682526 no 3160 0.0527961180252649 4453 6777674 SGTC_2322 7413319 38.22 µM -1.62316173994614 0.0585840633044733 no 3161 0.0522774171501339 4492 1840400 SGTC_995 3931-2021 34.6 µM -1.62393971752615 0.0584965665282927 no 3162 0.052194337421726 4558 730143 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.62407314932261 0.0584815701732782 no 3163 0.0521800988659666 4430 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1651 st011928 86.1 µM -1.62451016306734 0.0584324754788616 no 3164 0.0521334865669033 4564 720198 SGTC_1041 0206-0046 107 µM -1.63799427732846 0.0569334994958618 no 3165 0.0507114437827185 4574 50494 SGTC_3259 9138485 49.47 µM -1.63961234387638 0.0567556786943247 no 3166 0.0505428974418832 4532 17646153 SGTC_1693 xanthone 101.9 µM -1.64345744400713 0.0563348683480796 no 3167 0.0501441616466836 4622 7020 An insecticide. SGTC_1575 cyproterone acetate 48 µM -1.64410146920845 0.056264626880817 no 3168 0.0500776222699965 4546 9880 An androgen receptor antagonist and liver toxin. SGTC_2225 6654152 15.4 µM -1.64416716568396 0.0562574654897706 no 3169 0.0500708386022653 4509 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1268 0828-0275 2.46 µM -1.64520573156841 0.0561443497448209 no 3170 0.0499636959795469 4598 745337 SGTC_533 1222-0222 6.71 µM -1.64773975967466 0.0558691078571181 no 3171 0.0497030426914866 4586 3982874 SGTC_2005 4024620 188 µM -1.64824967339895 0.0558138507568438 no 3172 0.0496507236840548 4518 236743 SGTC_66 0109-0187 42.4 µM -1.65012460076384 0.0556110438473078 no 3173 0.0494587270557278 4425 759417 SGTC_2642 cholecalciferol 100 µM -1.65217008375765 0.0553904522028782 no 3174 0.049249941595596 4568 9821465 A vitamin D precursor, similar to steriods. SGTC_942 3253-1115 227 µM -1.65374218686115 0.0552213814545045 no 3175 0.0490899535318505 4588 46497897 SGTC_363 0455-0021 3.06 µM -1.66966840923566 0.0535314997062295 no 3176 0.0474924936588523 4517 4597466 SGTC_769 0302-0231 76 µM -1.66967679673406 0.0535306206537513 no 3177 0.047491663467884 4494 571869 YER009W NTF2 SGTC_1232 0279-0259 161 µM -1.67424620407178 0.0530534213613894 no 3178 0.0470411111562037 4565 1560000 SGTC_1058 3448-5425 97.3 µM -1.67481579308752 0.0529941743701116 no 3179 0.046985189621939 4520 7279705 SGTC_369 0957-0393 4.5 µM -1.67717497078034 0.052749338132822 no 3180 0.0467541359503152 4567 6997992 SGTC_530 4358-1714 28 µM -1.67807879600266 0.052655776971351 no 3181 0.0466658587778088 4566 1564641 SGTC_3340 9146634 11.102 µM -1.67888202552556 0.0525727397250622 no 3182 0.0465875191344426 4573 4907387 SGTC_1081 sertraline 6 µM -1.68653561648641 0.0517867207826237 no 3183 0.0458463404971772 4573 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3214 9129694 49.47 µM -1.68864271567511 0.0515719707865477 no 3184 0.0456439597722283 4565 17158655 SGTC_2671 danthron 100 µM -1.69328865794029 0.051100970465611 no 3185 0.0452002679849731 4578 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_167 3672-0051 66.205 µM -1.69796831423336 0.0506300192838549 no 3186 0.0447568711580319 4505 3237971 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.69922373483039 0.0505042661750136 no 3187 0.0446385179672901 4561 115019 SGTC_1491 4138-0063 26.5 µM -1.70469821087215 0.049958804084896 no 3188 0.044125361856369 4614 23883227 SGTC_2656 pseudo-anisatin 100 µM -1.71891480612997 0.048564226620942 no 3189 0.0428149428698245 4664 6708809 A neurotoxin. SGTC_2949 9072542 2.23 µM -1.72439780128826 0.0480347607195748 no 3190 0.0423180271144686 4565 16457352 SGTC_2965 9082772 38.63 µM -1.72509535953158 0.0479677334736812 no 3191 0.0422551443484068 4570 16459634 SGTC_2273 7815444 169.05 µM -1.72565875421131 0.0479136524558319 no 3192 0.0422044112304743 4529 2824616 SGTC_2345 9052315 157.45 µM -1.72815368747861 0.0476747468496107 no 3193 0.0419803371543068 4577 6469265 SGTC_886 0866-0150 153 µM -1.7321903104286 0.0472902360768725 no 3194 0.0416198418377278 4619 271463 SGTC_1370 2001-0092 44.6 µM -1.73403581751935 0.0471152711332392 no 3195 0.0414558641005772 4572 790957 SGTC_1614 st002383 48.6 µM -1.73592102831516 0.046937078268913 no 3196 0.0412888995325979 4633 1947235 SGTC_31 0508-1974 57.237 µM -1.74270715745373 0.0463001136331253 no 3197 0.0406923903883567 4560 6810525 SGTC_453 enantio-paf c16 10 µM -1.74291955951676 0.0462802895691712 no 3198 0.0406738334589612 4200 13871343 A lipid and platelet activating factor SGTC_324 1315-0088 19.6 µM -1.74571865825316 0.0460196782461393 no 3199 0.0404299256501115 4590 6787421 SGTC_2954 9074818 52.69 µM -1.75529420501842 0.0451370464873733 no 3200 0.0396044986028482 4596 16648742 SGTC_2970 9090938 41.86 µM -1.75662052626751 0.0450158732958574 no 3201 0.0394912559490397 4628 17217104 SGTC_911 3456-4043 236 µM -1.75884780193179 0.0448129777054704 no 3202 0.0393016815327971 4582 914281 SGTC_968 1309-0633 340 µM -1.76226787853187 0.0445028569557605 no 3203 0.0390120241565897 4642 3761976 SGTC_1995 st072814 61.1 µM -1.77361449429492 0.0434863502540103 no 3204 0.0380634692667773 4626 5769371 SGTC_1347 1493-0251 600 nM -1.77779792546559 0.0431163322888149 no 3205 0.0377185246724407 4652 3986378 SGTC_805 3852-0218 479 µM -1.78526190240698 0.0424624745996016 no 3206 0.0371094226677977 4605 6615355 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.79164986991737 0.0419092671279412 no 3207 0.0365945346685458 4588 279621 SGTC_1088 bifonazole 369 nM -1.79514037034202 0.0416094587679397 no 3208 0.0363156690654307 4624 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2418 pentamidine 31.67 µM -1.80816276507195 0.040506230314885 no 3209 0.0352905859500043 4574 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2686 alizarin 95.37 µM -1.81004466040348 0.0403487822600827 no 3210 0.0351444308504564 4596 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1087 pterostilbene 9.05 µM -1.81249019771922 0.0401449202656331 no 3211 0.0349552435893317 4629 5281727 Similar to reservatol, lowers cholesterol. SGTC_490 phenamil 164 µM -1.82287781086651 0.0392883069183671 no 3212 0.0341609496548945 4653 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1035 k081-0041 55.2 µM -1.82314255322618 0.0392666708770175 no 3213 0.0341409015318212 4636 731709 SGTC_2122 5258151 111.688 µM -1.82721286762987 0.0389352437534587 no 3214 0.0338338849485521 4644 2173356 SGTC_98 0074-0023 107.663 µM -1.82821231502463 0.0388542126169144 no 3215 0.0337588467403154 4632 3563821 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.84387748847694 0.0376019973759383 no 3216 0.0326004982603344 4541 4330530 SGTC_1895 st058434 18.3 µM -1.84417957025195 0.0375781778027811 no 3217 0.0325784873418219 4639 5393175 SGTC_2786 7743617 45.45 µM -1.84458107121231 0.0375465379577241 no 3218 0.0325492513068006 4573 583674 SGTC_1336 1486-0901 104 µM -1.84959768480694 0.0371530400555722 no 3219 0.032185778380763 4649 5006114 SGTC_918 glabranin 770.725 nM -1.85027146409991 0.0371004471588115 no 3220 0.0321372166811448 4632 124049 Also referred to as licorice root. SGTC_3334 9142812 21.919 µM -1.85369178503128 0.0368344062844232 no 3221 0.0318916338353875 4633 45283678 SGTC_1271 0832-2808 169 µM -1.8567616238179 0.0365969570637311 no 3222 0.0316725379011184 4662 3663794 SGTC_330 1488-0319 80.1 µM -1.86378678717804 0.0360582771096469 no 3223 0.0311758259837342 4668 6846614 SGTC_1921 5740136 50 µM -1.86563773017256 0.0359174352825195 no 3224 0.0310460335602918 4569 1774243 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.86729052870067 0.0357920518280392 no 3225 0.0309305136632278 4707 4213774 SGTC_2675 theaflavin digallate 100 µM -1.87308697865724 0.0353551571831613 no 3226 0.0305281875813338 4604 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_216 k038-0035 28.382 µM -1.87697796909368 0.0350643430181287 no 3227 0.0302605567114635 4613 4444231 YPR107C YTH1 SGTC_173 1273-0061 2.693 µM -1.87968939779131 0.0348628525911478 no 3228 0.0300752106838218 4594 2847414 YPL266W DIM1 SGTC_457 grayanotoxin iii 135 µM -1.88912884094816 0.0341687950583411 no 3229 0.0294372833737286 4452 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1000 4048-0884 8.67 µM -1.88974014733594 0.0341242417547342 no 3230 0.0293963609389827 4651 13040088 SGTC_342 k048-0088 23.3 µM -1.88974756576197 0.0341237013776113 no 3231 0.029395864620544 4657 6820570 SGTC_2469 5655019 90.81 µM -1.89596403733097 0.0336733445588568 no 3232 0.0289824000471013 4692 2788239 SGTC_1994 st072947 40.9 µM -1.89752789167841 0.0335608232859398 no 3233 0.0288791505983247 4674 5286565 YDL195W SEC31 SGTC_381 3461-2219 42.7 µM -1.9034347752883 0.0331386044882122 no 3234 0.0284919184894552 4637 2883159 SGTC_2275 7947463 200 µM -1.90449456894994 0.0330633163420513 no 3235 0.0284229016611987 4630 1225414 SGTC_155 k072-0202 43.6 µM -1.91059252361081 0.0326328491975601 no 3236 0.0280284829526317 4645 5857737 SGTC_634 1611-4317 11.2 µM -1.9122599939167 0.0325159471103572 no 3237 0.0279214272191044 4681 2843522 SGTC_1609 st001574 46.4 µM -1.9148093305324 0.03233788760827 no 3238 0.0277584120612614 4645 3960012 SGTC_3347 9188721 44.724 µM -1.91525942475775 0.032306534308845 no 3239 0.0277297136975944 4655 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2113 5491891 107.031 µM -1.92401625140929 0.0317015142645188 no 3240 0.027176273227396 4657 789979 SGTC_1102 cgs 12066b 26.1 µM -1.94610689579731 0.0302167445856381 no 3241 0.0258209502176837 4690 6438352 A 5-HT1B full agonist. SGTC_2505 galangin 7.89 µM -1.95652083994982 0.029537051139988 no 3242 0.0252019149668072 4636 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2904 7225135 42.03 µM -1.95964801530195 0.0293354428798509 no 3243 0.0250184725632007 4712 4446116 SGTC_726 3448-4391 34.2 µM -1.96677269389855 0.0288803816123788 no 3244 0.0246047109683194 4709 1356692 SGTC_1735 st034310 56.75 µM -1.97304271521191 0.0284847770052147 no 3245 0.0242453479624984 4678 871153 SGTC_937 3122-0005 46.7 µM -1.97814486682309 0.0281661950261159 no 3246 0.0239561831484815 4647 759535 SGTC_933 2914-0560 114 µM -1.97854613634282 0.0281412657930342 no 3247 0.0239335646215745 4685 463887 SGTC_2432 5630864 12.22 µM -1.98164719306751 0.0279492287211859 no 3248 0.0237593706517108 4672 5714970 SGTC_124 0136-0217 7.121 µM -1.9854531712474 0.0277150315636779 no 3249 0.0235470376319485 4718 3976905 SGTC_3175 9106517 49.47 µM -1.9886763455324 0.0275179777033911 no 3250 0.0233684692675354 4686 41468073 SGTC_941 3237-0776 460 µM -1.98893245802485 0.0275023700808955 no 3251 0.0233543292800956 4671 760008 SGTC_1664 st014217 9.02 µM -1.99127586910385 0.0273599038698404 no 3252 0.0232252834354266 4729 3982782 SGTC_1988 st071872 53.4 µM -1.99327041567152 0.0272391320092937 no 3253 0.0231159220521542 4707 16414116 SGTC_2255 7941087 197.44 µM -1.99673019375314 0.0270306937164127 no 3254 0.0229272501436155 4723 935561 SGTC_3 0833-0587 95.581 µM -1.99805995187993 0.0269509358436303 no 3255 0.022855080428929 4588 5382644 SGTC_2022 5136654 200 µM -1.99922346069611 0.0268813107068882 no 3256 0.0227920906256446 4646 1713771 SGTC_2980 9014342 25.29 µM -2.00409919003362 0.0265911749412959 no 3257 0.0225297180877519 4679 2996599 SGTC_1381 2324-0066 62.1 µM -2.00989638968883 0.0262496150629382 no 3258 0.0222210779780457 4690 10885928 SGTC_1013 4112-3890 241 µM -2.01939067392358 0.0256981559371431 no 3259 0.0217233150517376 4672 705171 SGTC_1837 st055472 66.5 µM -2.03767460455793 0.0246634686985024 no 3260 0.0207912427712422 4705 676091 SGTC_2139 5578692 56.4705 µM -2.03953620499354 0.0245601093345945 no 3261 0.0206982708272348 4681 650991 YMR113W FOL3 SGTC_2295 7971645 200 µM -2.04620179212812 0.024193000395276 no 3262 0.0203682605524525 4710 2978226 YKL099C UTP11 SGTC_451 chloral hydrate 100 µM -2.04948241407702 0.0240140184678916 no 3263 0.0202074828692118 4684 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_417 st075190 100 µM -2.07962161960877 0.022421172314867 no 3264 0.0187801261969466 4696 222757 SGTC_3275 9138069 49.47 µM -2.08565395730389 0.0221133066233953 no 3265 0.0185049899715579 4715 17617007 SGTC_171 k064-0041 9.68 µM -2.09766479738716 0.0215109389083851 no 3266 0.0179673833321409 4679 53325 SGTC_3078 9116413 49.47 µM -2.10224977619941 0.0212846795536373 no 3267 0.0177657007846979 4679 17177322 SGTC_1494 4358-1428 177 µM -2.10837355343134 0.0209856255306136 no 3268 0.017499345091829 4738 1564571 SGTC_2401 5128683 200 µM -2.12580739850387 0.0201536507948412 no 3269 0.0167596498719487 4681 708373 SGTC_50 0929-0078 56.389 µM -2.13806231514396 0.0195857107215647 no 3270 0.0162558429881116 4612 1377751 SGTC_3191 9110352 49.47 µM -2.14333618518504 0.019345515081145 no 3271 0.0160430566182495 4691 17122424 SGTC_1799 st045822 46.1415 µM -2.14382601989098 0.0193233333980708 no 3272 0.0160234148264573 4704 3674992 SGTC_1797 st048695 56.8 µM -2.16021005187644 0.0185937518126242 no 3273 0.0153782061803825 4700 592262 YIL048W NEO1 SGTC_896 0964-0007 44.5 µM -2.16531544811695 0.0183712557862806 no 3274 0.0151817680644466 4695 6756758 SGTC_1080 nisoldipine 24.4 µM -2.17492638010314 0.0179585558488816 no 3275 0.0148178168506815 4741 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1980 st071811 45.7 µM -2.18360661594732 0.0175926409665756 no 3276 0.0144955834980573 4748 4974850 SGTC_2661 dactinomycin 12.96 µM -2.18777890751574 0.0174190349411233 no 3277 0.014342855510066 4736 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1345 1488-0192 31.4 µM -2.18875065305025 0.0173788120092614 no 3278 0.0143074840877129 4743 658348 SGTC_3356 9151811 4.48 µM -2.19516495173323 0.0171152932723313 no 3279 0.0140758836971832 4746 1859254 YPR165W RHO1 SGTC_1306 1185-0270 9.02 µM -2.19963641057535 0.0169336188017883 no 3280 0.0139163508600014 4739 1548076 SGTC_2445 5742597 35.57 µM -2.21927123732873 0.0161552504985052 no 3281 0.0132341385857062 4713 1774255 SGTC_2062 5245942 200 µM -2.22750160236428 0.0158382153189566 no 3282 0.0129568844181456 4741 1376160 SGTC_421 streptovitacin 30 mM -2.22924440052991 0.0157717712384332 no 3283 0.0128988238877658 4710 91467 include heat shock SGTC_112 phenothiazine 287.218 µM -2.22961965655467 0.0157574959471775 no 3284 0.0128863518840354 4715 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1665 st014639 11.4 µM -2.24055413311555 0.0153463717139462 no 3285 0.0125274852875628 4774 981133 YIL048W NEO1 SGTC_841 0251-0215 91.2 µM -2.24467995142373 0.0151936567438757 no 3286 0.0123943430007065 4751 3888614 SGTC_679 0422-0091 41.4 µM -2.24555715407956 0.0151613563856208 no 3287 0.0123661937430695 4737 627384 YHR062C RPP1 SGTC_41 0478-0632 82.643 µM -2.25170998836967 0.0149364505926468 no 3288 0.0121703025218816 4703 3750424 SGTC_2477 5967686 25.23 µM -2.27264079610112 0.0141927081356714 no 3289 0.0115239175369962 4711 776118 SGTC_2773 thioridazine 9.09 µM -2.28534348452682 0.0137570757649254 no 3290 0.011146347525755 4730 5452 An antipsychotic. SGTC_608 k048-0125 159 µM -2.28893379980108 0.0136360580478754 no 3291 0.0110415995270927 4752 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2172 5754775 163.918 µM -2.30613146248969 0.0130690382314793 no 3292 0.0105516438851371 4722 2263357 SGTC_2130 NSC 7 2.4545 µM -2.3102162012473 0.0129373960108953 no 3293 0.0104380937668807 4738 21448 SGTC_810 3825-7150 143 µM -2.31511872900326 0.0127809135163432 no 3294 0.0103032176588154 4737 22330411 YGL099W LSG1 SGTC_483 fpl-64176 144 µM -2.32019030469425 0.0126207609491342 no 3295 0.0101652924245712 4791 3423 SGTC_1889 st059080 5.18 µM -2.32921826203522 0.0123399674374752 no 3296 0.00992375296976046 4724 176925 Isolated from Daphnopsis sellowiana. SGTC_756 0508-1999 28.3 µM -2.33355187885709 0.0122071137879623 no 3297 0.00980959941310611 4744 6753853 SGTC_931 2812-0076 566 µM -2.33851419608285 0.0120565103486122 no 3298 0.00968029505934514 4710 3450959 SGTC_2374 9071832 200 µM -2.34007291850861 0.0120095377269639 no 3299 0.00963998759977552 4728 17381698 SGTC_950 1165-0508 94.1 µM -2.34745932579194 0.0117890975297672 no 3300 0.00945096839924191 4725 6148369 SGTC_1091 telmisartan 47.6 µM -2.35734191136307 0.0114996582386292 no 3301 0.00920314533639942 4756 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_849 0386-0493 241 µM -2.36501896627373 0.0112790930861865 no 3302 0.00901457379833879 4747 726119 SGTC_1044 1222-0021 1.78 µM -2.37418316850546 0.011020623843707 no 3303 0.00879391157790791 4700 4306703 SGTC_1568 digitonin 820 nM -2.37623318931299 0.010963514903509 no 3304 0.00874520273683776 4714 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_811 0416-0114 265 µM -2.38345583801496 0.0107643549849993 no 3305 0.00857547108522384 4751 6612453 SGTC_997 3996-0078 137 µM -2.3903745059177 0.0105765384001858 no 3306 0.0084156000681183 4756 735687 SGTC_2176 5809774 33.9695 µM -2.40322934551765 0.0102351463025087 no 3307 0.00812549590517603 4727 2870539 SGTC_2406 ethylparaben 405.7 µM -2.41298769028353 0.00998244502806383 no 3308 0.00791117696888733 4714 8434 A possible steroid mimic. SGTC_3308 9128332 17.569 µM -2.42998116915282 0.00955536719075358 no 3309 0.00754980366103989 4731 17332805 YDL196W YDL196W SGTC_2905 7799065 20.05 µM -2.46474425948676 0.00873119496294158 no 3310 0.00685555372733327 4720 1296806 SGTC_3263 9137018 49.47 µM -2.51137331324062 0.00772390613060774 no 3311 0.00601312216569695 4736 43844957 SGTC_2411 st077133 39.94 µM -2.54729125028732 0.00701920577403053 no 3312 0.00542813918060651 4730 1403142 YNL221C POP1 SGTC_2339 9000433 200 µM -2.55003899297037 0.00696770939991831 no 3313 0.00538554356808058 4734 2988954 SGTC_2761 levamisole 97.89 µM -2.57809066146292 0.00646076805479211 no 3314 0.00496739642151913 4763 26879 An alkaline phosphatase inhibitor. SGTC_2981 9013952 38.96 µM -2.5946845509705 0.00617649722859122 no 3315 0.0047338884722481 4727 2996344 SGTC_435 c-PAF 6.7 µM -2.60119022140263 0.00606810749300317 no 3316 0.00464504627565155 4707 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3344 9148862 3.898 µM -2.62960881943452 0.00561414439874791 no 3317 0.00427415842576066 4780 4905352 SGTC_916 4466-0038 42 nM -2.64980874493754 0.00531006488065039 no 3318 0.00402686739708208 4775 5722064 YGL116W CDC20 SGTC_881 0833-0569 170 µM -2.68596448685396 0.00480218592100343 no 3319 0.0036160387583536 4781 5418700 SGTC_2370 9071495 200 µM -2.68850655196437 0.00476816345209317 no 3320 0.00358862135861595 4778 21791103 SGTC_1627 st003713 25.6 µM -2.70986015318682 0.00449075194242657 no 3321 0.00336557911750047 4757 16195070 YER133W GLC7 SGTC_935 2996-0153 430 µM -2.71029128478023 0.00448530258340615 no 3322 0.00336120712139609 4772 23738523 SGTC_1630 st005209 31.3 µM -2.71385060372643 0.00444053913338452 no 3323 0.00332530756579889 4770 3367314 SGTC_732 3970-1727 52.7 µM -2.71774387771619 0.00439203308330306 no 3324 0.00328643480020132 4788 1275699 SGTC_2681 menadione 3.18 µM -2.71915714777161 0.00437454270661927 no 3325 0.00327242528312376 4792 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1356 1502-0781 85.8 µM -2.721836106406 0.00434155912189893 no 3326 0.00324601652081615 4782 567702 SGTC_1567 st069303 68.4 µM -2.73076244446118 0.00423325546239527 no 3327 0.0031594000084804 4763 5581319 SGTC_288 1315-0019 35.1 µM -2.77853958054671 0.00369362213601392 no 3328 0.00273019302182066 4784 6811474 SGTC_159 3970-0959 50 µM -2.81682684333384 0.00330662484536862 no 3329 0.00242503331419933 4773 6615653 SGTC_2496 diffractaic acid 79.83 µM -2.8236138964236 0.0032419594348387 no 3330 0.00237427753614554 4768 94870 An apoptosis inducer which activates caspases. SGTC_3009 9080819 71.4286 µM -2.85613801547191 0.00294759297273597 no 3331 0.00214414340553933 4788 17027216 SGTC_895 0964-0006 13.7 µM -2.92179865524758 0.00242557028248408 no 3332 0.0017400821955275 4780 6738897 SGTC_2348 9022543 33.42 µM -2.98724851861503 0.00198993066859087 no 3333 0.00140750393404183 4784 3162678 YDL140C RPO21 SGTC_116 0155-0182 31.788 µM -3.00848481337856 0.00186465737557555 no 3334 0.00131276961941477 4754 771486 SGTC_1573 oleylamine 1.06 µM -3.01915382146084 0.0018044653219445 no 3335 0.00126740898068237 4779 5356789 An amine of the fatty acid oleic acid. SGTC_1432 4049-0298 68.4 µM -3.10679386128767 0.00137303327848423 no 3336 0.000945641150499766 4803 741646 SGTC_3006 9075424 71.4286 µM -3.13123120483061 0.00127080939839182 no 3337 0.000870375282188374 4791 7465181 SGTC_690 glyoxal 20.3 µM -3.21888478177592 0.000958781687485251 yes 3338 0.000643450914385671 4725 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2397 5161689 200 µM -3.27779475716446 0.000790431954071925 yes 3339 0.000523107181015847 4797 2259942 SGTC_2341 7987486 176.74 µM -3.4246478095231 0.000482106398657282 yes 3340 0.000307798438340165 4797 1258686 SGTC_3141 9094609 49.47 µM -3.45912750270401 0.000428104254253933 yes 3341 0.000270964149499243 4799 25236309 YDL196W YDL196W SGTC_2381 9035592 200 µM -3.45912912650438 0.00042810184871254 yes 3342 0.000270962515873855 4799 4749657 SGTC_1578 josamycin 24.2 µM -3.47983291446827 0.000398429404151684 yes 3343 0.000250863290733655 4802 5282165 A P450 substrate. SGTC_979 1426-2828 121 µM -3.49659410328546 0.000375817970119898 yes 3344 0.000235619126626597 4802 747872 SGTC_157 1348-1695 65.819 µM -3.59587126895858 0.000264549825302543 yes 3345 0.000161653830088382 4791 5380510 SGTC_2566 crystal violet carbinol 226 nM -3.62975685610864 0.000234213016057483 yes 3346 0.000141844157945845 4763 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2384 9036245 200 µM -3.63158553774904 0.000232671939800459 yes 3347 0.000140842629714102 4803 6462766 SGTC_3346 9158254 43.5805 µM -3.73519539692345 0.000159305080716552 yes 3348 9.37847458057395e-05 4804 17639500 SGTC_566 0958-0068 16.5 µM -3.95663848229413 6.86934380924005e-05 yes 3349 3.80059156084284e-05 4802 6815365 SGTC_1646 st011709 75.6 µM -4.01637639028662 5.43450012747619e-05 yes 3350 2.95499198655863e-05 4807 5757843 SGTC_2597 laccaic acid a 100 µM -4.17758640118495 2.84276526018018e-05 yes 3351 1.47309381377473e-05 4802 5491415 A textile dye. SGTC_771 0250-0039 27.3 µM -4.62546029799598 4.16366783414106e-06 yes 3352 1.86883699878823e-06 4809 3005115 SGTC_772 k072-0172 35.3 µM -4.70023777662202 2.96925621526516e-06 yes 3353 1.29929370442069e-06 4809 5861980 SGTC_770 0389-1121 67.2 µM -4.88767392470193 1.24479313406069e-06 yes 3354 5.10171714262709e-07 4809 6753108 SGTC_1570 verbenone 133 µM -5.72762241862739 1.71966129694447e-08 yes 3355 5.09239693360321e-09 4809 29025 A natural terpanoid with antifungal properties. SGTC_768 0384-0033 77.3 µM -5.87422179920547 7.6320535398637e-09 yes 3356 2.12417130346989e-09 4810 3965305 YMR134W ERG29