SGTCid condition conc unit ABM1|YJR108W.score ABM1|YJR108W.strain.pval ABM1|YJR108W.strain.significant ABM1|YJR108W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1783 st039459 87.517 µM 3.96347124144291 1.48014125359808e-05 yes 1 3.69338828519779e-05 22 729761 SGTC_736 0958-0254 92.6 µM 3.74156679119622 4.01435729437109e-05 yes 2 9.14382796860112e-05 40 6812352 SGTC_310 1273-0058 1.06 µM 3.71297413652421 4.54793746873544e-05 yes 3 0.000102418913536269 262 2734232 SGTC_917 harmaline 728.087 nM 3.70565042876704 4.69501439382743e-05 yes 4 0.000105424471349076 34 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_43 0570-0105 72.5 µM 3.49351509786346 0.00011519267881453 yes 5 0.000238353013816125 134 1114046 YDL195W SEC31 SGTC_1055 3448-0672 86 µM 3.46003513585462 0.000132152717193301 yes 6 0.000270052454094977 51 748378 SGTC_170 4197-0004 226 µM 3.35140887229152 0.000204701619473777 yes 7 0.000402007479413833 33 218692 SGTC_2780 5215298 71.43 µM 3.28893885641943 0.000261817896639981 yes 8 0.000502829340200736 70 2834131 SGTC_532 1548-0774 215 µM 3.27889491650718 0.000272281964722177 yes 9 0.000521072172855078 41 5932993 SGTC_1967 st070177 51.4 µM 3.14796529914555 0.00044949358084747 yes 10 0.000822056047854588 48 5729214 SGTC_1378 2093-0007 380 nM 3.1413168144556 0.000460863826992457 yes 11 0.000840949934109781 55 3618014 SGTC_1134 3477-0009 42.5 µM 3.09122946790503 0.000555479691894094 yes 12 0.000996647634909902 87 3973534 SGTC_2572 astragaloside iv 100 µM 3.07813588344489 0.000583018314745801 yes 13 0.00104149955245171 70 45006101 An anti-inflammatory agent. SGTC_1842 st055362 61.2 µM 3.01851201289034 0.000725106230046735 yes 14 0.00127009665323651 52 676032 SGTC_299 1273-0059 1.44 µM 2.99859208477592 0.000779277385354507 yes 15 0.00135615089236731 56 2848077 SGTC_996 3970-0799 1.8 µM 2.95785801449689 0.000901831177613388 yes 16 0.00154892389675869 160 6615648 YGL040C HEM2 SGTC_156 3474-0145 5.642 µM 2.95138796517774 0.000922852957172093 yes 17 0.00158174643606775 102 2265471 SGTC_3165 9101544 49.47 µM 2.93053464074531 0.000993709115233397 yes 18 0.00169189632062116 43 5002184 SGTC_743 1275-0778 158 µM 2.92136766133974 0.001026409289677 no 19 0.00174249148385662 103 2849257 YMR203W TOM40 SGTC_2058 5236698 133 µM 2.91936033490619 0.00103370025692418 no 20 0.00175375263412841 76 766665 SGTC_2429 5902844 64.44 µM 2.84363819283543 0.00134600002941038 no 21 0.00223008315490559 101 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1373 2887-0003 58.5 µM 2.8356531767523 0.00138352284995329 no 22 0.00228660394290245 79 776948 SGTC_2938 9059746 27.26 µM 2.81246306861152 0.00149797808495195 no 23 0.00245818344190032 99 6471769 SGTC_2957 9076800 11.52 µM 2.74883836381037 0.0018577442250422 no 24 0.00299034353435447 74 16459615 SGTC_132 0417-1715 25.805 µM 2.73722758685099 0.00193130678124016 no 25 0.00309797060000343 67 6769098 SGTC_2925 9010536 32.5 µM 2.72796748013812 0.00199186223930801 no 26 0.00318629450400342 134 2994177 SGTC_1572 epiandrosterone 68.9 µM 2.70987910230061 0.00211514690917636 no 27 0.00336538685200399 91 441302 A steroid. SGTC_2939 9044578 71.43 µM 2.70962130153025 0.00211695295712486 no 28 0.00336800345127019 111 2653634 SGTC_1635 st007035 42.4 µM 2.6991371575176 0.00219159630666189 no 29 0.00347597590910636 328 3716403 SGTC_164 4100-3994 89.624 µM 2.69224052077609 0.00224199036444069 no 30 0.00354868699568061 119 4615967 SGTC_3192 9110362 49.47 µM 2.64971090178135 0.00257664238252573 no 31 0.00402803367062285 69 16649480 SGTC_827 3253-0474 693 µM 2.63797550809444 0.0026766128076249 no 32 0.00417013026208531 95 5402065 SGTC_3223 9129970 49.47 µM 2.63567499500273 0.00269661601456053 no 33 0.00419850577455588 96 17248386 SGTC_792 4534-1957 155 µM 2.62067333158463 0.00283040049883033 no 34 0.0043878153254891 110 1717904 SGTC_1546 5-methoxyflavanone 78.7 µM 2.61621057916115 0.00287133889848831 no 35 0.004445585242871 69 147795 SGTC_1756 st041558 35.5 µM 2.61569702696215 0.00287608399060083 no 36 0.00445227652870923 58 3955792 SGTC_930 2810-3379 265 µM 2.61469583660114 0.00288535507137027 no 37 0.00446534732504563 87 1015764 SGTC_1330 1469-0054 61.8 µM 2.60656105009953 0.00296168833838444 no 38 0.00457282593403231 89 7102664 SGTC_46 0329-0187a 2.197 µM 2.59434407454348 0.00307974894622118 no 39 0.00473857951610118 182 46494817 SGTC_3189 9110682 49.47 µM 2.57872710105485 0.00323683040742094 no 40 0.00495825464357926 107 17122418 SGTC_536 3852-0578 10.6 µM 2.54982368082602 0.0035466790622194 no 41 0.0053888705826473 102 2869208 SGTC_533 1222-0222 6.71 µM 2.53799341039607 0.00368100195303541 no 42 0.00557450418390756 117 3982874 SGTC_37 0566-0070 1.56 µM 2.53278799213507 0.00374153766363845 no 43 0.00565796856162249 136 1626686 SGTC_2080 5212524 12.4 µM 2.51993559391293 0.00389484348078189 no 44 0.00586881545843153 85 260183 SGTC_2978 9011784 42.97 µM 2.51302444816148 0.00397958695171881 no 45 0.00598505196266849 167 2994934 SGTC_1144 3486-0183 12.5 µM 2.50845200110914 0.00403655751116359 no 46 0.00606307207715 121 6744069 SGTC_162 k030-0015 37.8 µM 2.4838847964667 0.00435533567774746 no 47 0.00649789216479736 97 1809920 YMR134W ERG29 SGTC_599 1935-0052 86.5 µM 2.46018121272169 0.00468404253341698 no 48 0.00694334396675451 120 9557311 SGTC_2281 7943571 200 µM 2.43279299320518 0.00509126340812934 no 49 0.00749143201865682 99 1244024 SGTC_847 0342-0274 5.54 µM 2.41999561421622 0.00529212420639162 no 50 0.0077603471468116 118 18097 SGTC_1870 st057514 26.5 µM 2.41763833138052 0.00532988216365206 no 51 0.00781079749809867 140 5393161 SGTC_2689 tacrolimus 100 µM 2.41723002426965 0.00533644653953333 no 52 0.00781956530855527 156 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1452 4194-0072 190 µM 2.39509817987736 0.00570319436279621 no 53 0.00830795769056532 135 1343545 SGTC_2871 9038510 12.99 µM 2.38320431932326 0.00590939013978604 no 54 0.00858133283206444 125 4945164 SGTC_155 k072-0202 43.6 µM 2.37088444937247 0.00612991608358861 no 55 0.00887278897874038 110 5857737 SGTC_2076 5212012 200 µM 2.32862158953943 0.00694283410995693 no 56 0.00993956064982009 65 604802 SGTC_300 r073-0011 5.04 µM 2.31834651260147 0.00715431233311035 no 57 0.0102152482319017 147 2735780 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 2.29710576839405 0.00760957432499877 no 58 0.0108063683972169 160 688761 SGTC_621 3584-0052 32.1 µM 2.29295377240599 0.00770148828974346 no 59 0.0109253332585912 155 2273927 SGTC_1563 conessine 56.1 µM 2.28577192090863 0.00786278369337134 no 60 0.0111338025938381 169 441082 An anti-amoebic, histamine inhibitor. SGTC_172 1112-0046 2.638 µM 2.28115632257423 0.00796800603415135 no 61 0.0112695991422871 147 2802135 YIL048W NEO1 SGTC_114 0364-0001 490.298 µM 2.2793233648143 0.00801013444880479 no 62 0.011323925058187 201 4003655 SGTC_1961 st076550 68.7 µM 2.27110721573668 0.00820138849609559 no 63 0.011570244146406 132 1579337 SGTC_2287 7945887 168.79 µM 2.2633638459441 0.0083852975389732 no 64 0.0118066347602269 127 1245853 SGTC_521 r062-0005 13.8 µM 2.24701449923189 0.00878553364869561 no 65 0.0123195502474628 142 2832033 SGTC_1568 digitonin 820 nM 2.23169276405816 0.0091757147648021 no 66 0.0128176379100492 184 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2082 5219693 150 µM 2.22757431103316 0.00928314767490862 no 67 0.0129544576523739 182 2834649 SGTC_2425 5628681 7.85 µM 2.20747720121866 0.00982333426685908 no 68 0.0136403690381875 189 5714958 SGTC_382 3229-0966 23.2 µM 2.20245648641295 0.00996249711929674 no 69 0.0138165397936059 166 5722370 SGTC_624 k048-0052 28 µM 2.19727458008163 0.0101079295791615 no 70 0.0140004209878233 166 6835531 SGTC_1357 1503-1303 39.5 µM 2.19231397427677 0.0102488831061582 no 71 0.0141784217035668 203 292895 SGTC_859 0439-0102 54.6 µM 2.19041923383533 0.0103031720637386 no 72 0.0142469231853404 165 610143 SGTC_1268 0828-0275 2.46 µM 2.17571586836604 0.0107330489139262 no 73 0.0147882564534529 184 745337 SGTC_1253 0550-0034 176 µM 2.17435759172665 0.0107735372703469 no 74 0.0148391451772863 165 5969915 SGTC_2873 9040596 71.43 µM 2.17053115694478 0.0108883137608203 no 75 0.0149833154771063 211 6463863 SGTC_2482 5981709 142.65 µM 2.16354885970632 0.0111004968828723 no 76 0.0152494950147889 221 877755 SGTC_2383 9036125 200 µM 2.15813241018035 0.0112675638576107 no 77 0.0154587692742745 111 79580 SGTC_1753 st043925 64 µM 2.15335212667192 0.0114168199592024 no 78 0.0156455074882153 160 670181 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 2.14176053927814 0.0117858988312374 no 79 0.0161063781650341 273 6708739 YPR165W RHO1 SGTC_620 0109-0052 432 µM 2.12775515937333 0.0122456083328659 no 80 0.0166786944676197 183 493037 SGTC_1200 1643-0193 18.4 µM 2.10661835846969 0.0129687982998318 no 81 0.0175753370503217 196 5403974 SGTC_1206 3978-0017 132 µM 2.10315114990015 0.0130908871647102 no 82 0.017726279460319 191 3873677 SGTC_627 1391-0720 175 µM 2.10078206779762 0.0131748784798823 no 83 0.0178300506435948 176 997839 SGTC_365 0121-0052 13.6 µM 2.0978535619507 0.0132793463310094 no 84 0.017959041647203 297 3101739 SGTC_282 k297-0036 65.7 µM 2.08866202300262 0.0136118942281719 no 85 0.0183690788681784 140 5061378 SGTC_1235 benzylparaben 21.5 µM 2.08551329183187 0.0137274555428384 no 86 0.0185113664531752 172 7180 SGTC_1008 4106-0037 6 µM 2.08325452354862 0.013810874857859 no 87 0.0186140147936785 167 2905394 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.08297033004504 0.013821401403284 no 88 0.0186269640472019 215 5377381 SGTC_1875 nocodazole 6 µM 2.08093699540269 0.0138969183059306 no 89 0.0187198366711738 196 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1602 st001878 87.6 µM 2.05860564212894 0.0147499763759458 no 90 0.019766015914478 191 595405 YLR310C CDC25 SGTC_2436 5633522 8.09 µM 2.05627273617613 0.0148416389229729 no 91 0.0198781173517049 217 5724242 SGTC_3134 9127454 49.47 µM 2.04995125099913 0.0150924830598896 no 92 0.020184594086715 165 24262820 SGTC_2868 9035608 32.47 µM 2.02891894807877 0.0159534642852411 no 93 0.0212332732399146 202 6462614 SGTC_168 3970-0862 530.542 µM 2.0086425932582 0.0168230257315745 no 94 0.0222875254070044 445 3135186 SGTC_2585 alliin 100 µM 2.00759781356894 0.016868909131346 no 95 0.0223430235492719 241 87310 A garlic compound which reacts with lipids. SGTC_1996 st072960 66.8 µM 2.00728352708672 0.0168827325151461 no 96 0.0223597410712655 205 1719405 SGTC_1125 tnp00248 1.32998 µM 1.98703790832225 0.0177938475314584 no 97 0.0234590980603695 313 24207736 SGTC_460 trequinsin 123 µM 1.98520210779579 0.0178785006457292 no 98 0.0235609949541402 152 5537 A vasodilator. SGTC_1093 fluphenazine 7.97 µM 1.98268610004612 0.0179950775328501 no 99 0.0237012515868649 235 6602611 An atypical antipsychotic. SGTC_1618 st003135 44.5 µM 1.97694339337472 0.0182635905864081 no 100 0.0240240145478195 190 1270615 SGTC_2272 7805186 180 µM 1.97663622168464 0.0182780487635275 no 101 0.024041382372689 181 2956062 YPR165W RHO1 SGTC_3077 9117319 49.47 µM 1.97041862991889 0.0185728060537972 no 102 0.0243952060896056 174 17154678 SGTC_2284 7945075 39.21 µM 1.97003777674144 0.018590991948911 no 103 0.0244170206103543 257 1245402 SGTC_279 1273-0055 2.93 µM 1.96714130301089 0.0187297964524568 no 104 0.024583461362775 249 2847562 SGTC_1628 st004252 77.7 µM 1.96481998632094 0.0188416740920179 no 105 0.0247175380601807 240 692968 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.95693393647451 0.0192260045090849 no 106 0.0251776179948286 242 1377 SGTC_1643 st009866 20.2 µM 1.95407964871275 0.0193667423559006 no 107 0.0253458992366123 185 3156273 YOR207C RET1 SGTC_2046 4110841 106 µM 1.95255346825209 0.0194423530285365 no 108 0.0254362647235987 219 44119630 YMR134W ERG29 SGTC_3135 9127742 49.47 µM 1.9451200415353 0.0198142178349524 no 109 0.0258802661572984 200 3643468 SGTC_2703 st077852 53.4 µM 1.9411571537953 0.0200149205016041 no 110 0.0261196091751287 236 6281836 SGTC_3316 9136639 10.545 µM 1.92818187026329 0.020684169545261 no 111 0.0269162542136999 215 4903665 SGTC_3182 9108849 49.47 µM 1.92780428103407 0.0207039255466159 no 112 0.0269397375186873 269 17133045 SGTC_3146 9095609 49.47 µM 1.92015687348192 0.0211075010587657 no 113 0.0274190436060977 230 17173999 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.91678546667076 0.0212875225088168 no 114 0.0276325960216645 260 6708784 An antioxidant flavonoid SGTC_281 1672-3440 14.9 µM 1.90897632573278 0.0217094958218836 no 115 0.0281325728747609 220 6833000 SGTC_133 0724-0033 378.92 µM 1.9077819342955 0.0217746547025429 no 116 0.0282097033328444 226 280309 SGTC_2767 sibutramine 71.45 µM 1.90475565032369 0.0219404906436432 no 117 0.0284059206589286 233 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2328 6201408 200 µM 1.9016992003837 0.0221090607958613 no 118 0.0286052452371421 239 2890418 SGTC_774 k060-0086 136 µM 1.90091026020522 0.0221527497067361 no 119 0.0286568839786116 272 5911235 SGTC_2624 nerol 100 µM 1.90003246538311 0.0222014447016022 no 120 0.0287144296391374 202 637566 A natural product oil. SGTC_2645 abamectin 100 µM 1.89626526486743 0.0224114540941513 no 121 0.0289624884564734 261 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_188 3229-0966 278.469 µM 1.89317254543627 0.0225851133804907 no 122 0.029167463594094 301 5722370 SGTC_448 monastrol 171 µM 1.88976563848903 0.0227777264151166 no 123 0.0293946555215261 230 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.88728273455709 0.0229189704026005 no 124 0.0295611537082728 281 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1672 st016598 6.51 µM 1.86343734748012 0.0243134072872971 no 125 0.0312003798056087 314 4665860 YNL267W PIK1 SGTC_1412 3909-8563 178 µM 1.86224399183846 0.0243850249764915 no 126 0.0312843530658561 286 23767530 SGTC_2934 9036370 36.88 µM 1.85971866573335 0.0245371632209465 no 127 0.0314626698852117 295 6462800 SGTC_2145 5634607 200 µM 1.85243177594524 0.0249806339682152 no 128 0.0319819229456187 207 308662 SGTC_2772 vinpocetine 57.06 µM 1.84954349320458 0.0251582612502693 no 129 0.0321896867950701 278 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_140 0062-0056 502.533 µM 1.84420161084918 0.0254895726687829 no 130 0.0325768818533062 305 3758964 SGTC_2774 tamoxifen 10.92 µM 1.83494858304901 0.0260721037461277 no 131 0.0332566540992807 254 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1477 0139-0234 16 µM 1.83136682802848 0.0263005653885883 no 132 0.0335229045288265 247 620880 SGTC_2549 cedrol 20.94 µM 1.83061132021749 0.0263489684461841 no 133 0.0335792888512395 210 6708665 A sedative which affects the nervous system. SGTC_3045 9092950 49.47 µM 1.82749133287111 0.0265496457517807 no 134 0.0338129640859911 282 44120432 SGTC_2941 9056145 11.23 µM 1.82343076457553 0.0268127320229657 no 135 0.0341190871729347 189 2119517 SGTC_2326 6164455 177.58 µM 1.81929707757344 0.0270827880722628 no 136 0.0344330595071674 267 2888790 SGTC_2892 9047358 58.44 µM 1.81272082380544 0.0275170940741122 no 137 0.0349374455228329 206 6466771 SGTC_2408 sulbentine 18.36 µM 1.81228028470417 0.0275463942993926 no 138 0.0349714496383796 292 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1184 1269-1718 139 µM 1.80561516454311 0.0279928735428524 no 139 0.0354892361402158 274 5403821 SGTC_1548 st061468 90.8 µM 1.80160811699783 0.0282641846392544 no 140 0.0358035416502754 245 390799 SGTC_371 0195-0006 7.36 µM 1.80137830799298 0.0282798107911882 no 141 0.0358216363873143 237 3928593 SGTC_2386 9075165 157.42 µM 1.79910452814746 0.0284348071822276 no 142 0.0360010737555787 232 16452277 SGTC_2684 capsaicin 100 µM 1.79675395069159 0.0285957810000523 no 143 0.0361873449243517 270 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_411 enrofloxacin 100 µM 1.79445599715527 0.0287538829800935 no 144 0.0363702079875143 257 71188 A bacterial gyrase inhibitor. SGTC_2359 9039622 200 µM 1.79391373316549 0.0287912971999442 no 145 0.0364134695603537 289 6463596 SGTC_82 0054-0107 293.755 µM 1.78150412203664 0.0296586371375135 no 146 0.0374150660487523 245 3104697 SGTC_1973 st070275 50.2 µM 1.77552103134103 0.0300844951423119 no 147 0.0379059480387278 255 17118334 SGTC_3210 9128157 49.47 µM 1.77550841175537 0.0300853986953373 no 148 0.0379069889382124 331 17590849 SGTC_1975 st070967 30.8 µM 1.77167247224671 0.0303610938588128 no 149 0.0382244708737589 340 261391 SGTC_2514 salinomycin 42.74 µM 1.76977183536999 0.0304984693733921 no 150 0.0383825787597102 368 23682228 A polyether potassium ionophore. SGTC_2694 st077685 81.9 µM 1.76815877123707 0.0306154630833903 no 151 0.0385171822587691 307 2838096 SGTC_2216 7189485 200 µM 1.76523237073017 0.0308286603425979 no 152 0.0387623601550406 212 731273 SGTC_1059 3448-6867 171 µM 1.76228369272043 0.0310447221687379 no 153 0.0390106888498384 295 3934407 SGTC_920 mycophenolic acid 780.421 nM 1.76218993075074 0.0310516129976097 no 154 0.0390186063974323 302 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2976 9009005 19.48 µM 1.7535391694971 0.0316928479006103 no 155 0.0397547510939486 291 2993148 SGTC_394 menadione 8.33 µM 1.7497164626824 0.0319796705005973 no 156 0.0400836257731545 305 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1270 0831-1170 17.3 µM 1.746182150094 0.0322467583915135 no 157 0.0403896527471504 309 6764716 SGTC_2480 5767542 37.17 µM 1.74494061221467 0.0323410172391799 no 158 0.0404976035340052 280 2867358 SGTC_1659 st012954 42.1 µM 1.74400587830798 0.0324121331375401 no 159 0.0405790324128018 261 24207262 SGTC_1780 st038448 24.544 µM 1.7424330764928 0.0325320853280246 no 160 0.0407163461701922 297 728868 YDL195W SEC31 SGTC_392 N-ethylmaleimide 8.33 µM 1.73588747361817 0.0330352354308259 no 161 0.0412918665480098 283 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2217 6934799 96.0675 µM 1.73366254473678 0.0332077156293013 no 162 0.0414889879801634 267 675606 SGTC_3063 1327-0034 4 µM 1.72677421096502 0.0337464196661684 no 163 0.0421041108847714 299 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1689 st020265 53.493 µM 1.72555898809229 0.0338421986406656 no 164 0.0422133914750395 295 5758320 YPR016C TIF6 SGTC_960 1222-0186 7.7 µM 1.72034045949133 0.0342560474640177 no 165 0.0426852865155722 319 3126296 SGTC_2074 5212007 75.395 µM 1.72015382328386 0.0342709251197182 no 166 0.0427022421071055 249 758611 SGTC_2048 5246248 200 µM 1.7194971656734 0.0343233126269142 no 167 0.0427619416508583 240 677046 SGTC_2030 5175110 200 µM 1.71795959760261 0.0344462358167757 no 168 0.0429019924638553 295 2831986 SGTC_1120 ficusin 1.78878 µM 1.71739055522524 0.0344918203709486 no 169 0.0429539180972172 300 6199 A DNA cross-linker. SGTC_2614 arthonioic acid 13.39 µM 1.7143186771089 0.0347387574662847 no 170 0.0432351073997769 290 6710684 SGTC_2388 9080168 200 µM 1.71383279894744 0.0347779480878551 no 171 0.0432797188948953 258 15943073 SGTC_1630 st005209 31.3 µM 1.71049299048335 0.0350483183348914 no 172 0.0435873742605198 366 3367314 SGTC_3124 9127567 49.47 µM 1.70823107540349 0.0352324068617072 no 173 0.0437967372862879 290 17592030 SGTC_3121 9125696 49.47 µM 1.70652532194734 0.0353717555412416 no 174 0.0439551579215771 244 1235365 SGTC_640 3381-0960 37.1 µM 1.70551312697547 0.0354546585870544 no 175 0.0440493830820727 318 1745025 SGTC_1620 st003704 16.5 µM 1.70367681267563 0.035605467175142 no 176 0.044220741174174 283 2834414 SGTC_998 3996-0085 177 µM 1.70075236445838 0.0358467247251987 no 177 0.0444947488139543 361 715391 SGTC_3034 9090421 49.47 µM 1.69924287041088 0.0359717762398692 no 178 0.0446367159369182 270 17173761 SGTC_3073 9114972 49.47 µM 1.693342929736 0.0364639791429123 no 179 0.0451951055572688 285 41905075 SGTC_1422 4031-0024 15.5 µM 1.69036264124507 0.0367146971410187 no 180 0.0454792988503233 307 782427 SGTC_469 w7 172 µM 1.68692984682398 0.0370052278740098 no 181 0.0458084210849731 224 45115570 A P450 inhibitor. SGTC_2696 st077691 74.316 µM 1.68481439873748 0.0371852004805439 no 182 0.0460121930058328 312 757133 SGTC_1018 4259-0013 28.1 µM 1.68287618727002 0.0373507218562195 no 183 0.0461995311368903 315 6801262 SGTC_52 0329-0193 875 nM 1.67798297876853 0.0377712760043704 no 184 0.0466752109646601 343 3739292 SGTC_2174 5790901 200 µM 1.67431296749926 0.0380892305048726 no 185 0.0470345536469806 354 786020 SGTC_3147 9097027 49.47 µM 1.67278713647507 0.0382220630920201 no 186 0.047184604045493 328 25236841 SGTC_3104 9120930 49.47 µM 1.6685198568987 0.0385955615094909 no 187 0.0476062867197308 281 17014836 SGTC_3143 9086658 49.47 µM 1.66659548832893 0.0387649643035465 no 188 0.0477974333101958 416 25236626 SGTC_2880 9042983 58.44 µM 1.66634667837283 0.0387869112764791 no 189 0.0478221922817931 346 6464714 SGTC_2963 9082507 9 µM 1.66521270058315 0.0388870651514769 no 190 0.0479351639962941 323 16459611 SGTC_555 4296-0685 37 µM 1.66507116192097 0.0388995807368751 no 191 0.0479492796666549 348 2908540 YHR072W ERG7 SGTC_898 1000-0849 28.3 µM 1.66295849941867 0.0390867835640953 no 192 0.0481603715274314 294 6751807 SGTC_2798 7813637 45.45 µM 1.6623706119394 0.0391390064568194 no 193 0.0482192438071937 368 956368 SGTC_877 0771-0151 33.1 µM 1.65947737642001 0.0393968448907015 no 194 0.0485098178820601 366 6166523 SGTC_2674 ligustilide 100 µM 1.64369033594709 0.0408281929815315 no 195 0.0501200915932011 295 5319022 A signalling regulator. SGTC_742 0kpi-0133 140 µM 1.64270272533453 0.0409191200460421 no 196 0.0502222273237093 359 2728852 SGTC_1159 4092-0538 61.2 µM 1.63701775454073 0.0414457213914924 no 197 0.0508133799334097 381 717301 SGTC_2280 7785178 200 µM 1.63551629667591 0.0415857150750555 no 198 0.0509704306140337 304 2954328 SGTC_406 estrone 100 µM 1.62708856580491 0.0423786293760281 no 199 0.0518591445602468 354 5870 A steroid. SGTC_2083 5306046 65.942 µM 1.62519156973284 0.0425587819521425 no 200 0.0520608730842003 393 539837 SGTC_1239 0337-0584 35.4 µM 1.61369556896953 0.0436638138214851 no 201 0.0532967377751368 444 914301 YML130C ERO1 SGTC_2458 5808907 16.39 µM 1.61357782180259 0.0436752507038972 no 202 0.0533095153216 327 2731747 SGTC_1085 doxorubicin 7.67 µM 1.60970225323884 0.0440530390412951 no 203 0.0537314364168094 412 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_591 4299-0174 154 µM 1.60519698988362 0.0444955169088694 no 204 0.0542252298558584 323 5509088 SGTC_833 3852-0053 558 µM 1.60370687961963 0.0446426514494127 no 205 0.0543893393752082 395 3123681 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.60091216837681 0.0449196597532045 no 206 0.0546981870333899 253 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_257 daunorubicin 18.5 µM 1.59781594311078 0.0452281676521525 no 207 0.0550419726962548 320 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1561 5-methoxyflavone 52.9 µM 1.59045132517856 0.0459688299324388 no 208 0.0558665545216614 275 94525 SGTC_1988 st071872 53.4 µM 1.59010962528634 0.0460034299808821 no 209 0.0559050483652988 316 16414116 SGTC_2427 5545055 42.75 µM 1.58829485646279 0.0461875416854482 no 210 0.0561098400240498 399 5372858 SGTC_2371 9071574 200 µM 1.58411813037888 0.0466135268526692 no 211 0.0565834196362158 306 45596039 SGTC_1569 carminic acid 40.6 µM 1.58015630661115 0.047020502115827 no 212 0.0570355375904234 370 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3145 9085516 49.47 µM 1.57982527892662 0.0470546352525511 no 213 0.0570734424009921 372 25236195 SGTC_1041 0206-0046 107 µM 1.5755351007439 0.0474988064588687 no 214 0.057566491501069 379 50494 SGTC_824 1304-0008 100 µM 1.57104371366205 0.0479674016963513 no 215 0.0580862476656331 430 768245 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.57032043377204 0.0480432076662056 no 216 0.0581702913470703 333 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1824 st053723 68.6 µM 1.56755822596007 0.0483335935214465 no 217 0.0584921338137281 397 675225 SGTC_143 4032-1194 15.74 µM 1.56126195488278 0.0490007568863255 no 218 0.0592309781344687 482 1806963 SGTC_1262 0737-0114 49.6 µM 1.55912502148652 0.0492288549497412 no 219 0.0594833962666839 460 765919 SGTC_1777 st045864 34.765 µM 1.55770941425075 0.0493804243858287 no 220 0.0596510739078438 393 4691462 SGTC_2227 7312221 64.1025 µM 1.55764717233969 0.0493870971843459 no 221 0.0596584549084909 321 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_63 0099-0242 26.702 µM 1.55740461989876 0.0494131074893238 no 222 0.0596872249882543 463 3898502 YLR359W ADE13 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.55730367517436 0.0494239355996281 no 223 0.0596992016341809 427 165506 SGTC_3160 9100216 49.47 µM 1.55261344238362 0.0499291381694746 no 224 0.0602577561374612 376 17191039 SGTC_367 0335-0881 7.1 µM 1.54709780614375 0.0505285082008531 no 225 0.0609198314445297 440 23828853 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.54544282651991 0.0507094642862991 no 226 0.0611195940433916 450 5024745 SGTC_2705 st078069 42.8 µM 1.54518579146844 0.0507376148390881 no 227 0.0611506650703669 362 1530061 SGTC_1499 4480-0877 67.3 µM 1.54496625706552 0.0507616681624791 no 228 0.0611772126999531 325 2861909 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.53980687009671 0.0513295759554742 no 229 0.0618037184093188 386 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1100 amiodarone 5.07 µM 1.53659055072701 0.0516861548140985 no 230 0.062196803990159 425 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_762 1165-0429 115 µM 1.53446063327759 0.05192337102225 no 231 0.0624581854320017 406 5967793 SGTC_2858 9025781 8.96 µM 1.5320799298058 0.0521895411513275 no 232 0.0627513558897948 539 4894980 YPL153C RAD53 SGTC_2338 7999974 200 µM 1.53078698348478 0.0523345500452175 no 233 0.0629110238175989 431 315925 SGTC_2419 paclitaxel 166.5 µM 1.53033195675246 0.0523856590795499 no 234 0.0629672910024095 486 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1165 k072-0275 30.3 µM 1.52548342535276 0.0529327147894805 no 235 0.0635692822772926 384 6153523 YGL055W OLE1 SGTC_3046 9092212 49.47 µM 1.52291387669715 0.0532244663570691 no 236 0.0638901267859296 378 25236637 SGTC_2152 5568786 200 µM 1.52246429914444 0.0532756430526877 no 237 0.0639463921317664 408 5399883 SGTC_893 0958-0369 48.9 µM 1.51912611720112 0.05365685883773 no 238 0.0643653769362736 445 6819948 SGTC_2752 diclazuril 33.15 µM 1.5064701016859 0.0551218171629884 no 239 0.0659732683559952 597 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_597 k018-0003 82.8 µM 1.49668440855535 0.056276046899228 no 240 0.0672376975381752 441 6786234 SGTC_2088 5278280 127.392 µM 1.4957767606895 0.0563840631369277 no 241 0.0673559196334273 461 791502 SGTC_1775 st081588 35.1725 µM 1.49406085124532 0.0565887144022481 no 242 0.0675798575840341 463 1426443 YGL099W LSG1 SGTC_3109 9122853 49.47 µM 1.49237173296798 0.0567907415497008 no 243 0.0678008605468553 414 1234709 SGTC_759 3486-0358 89.3 µM 1.49070384405393 0.0569907865469999 no 244 0.068019633205857 469 875103 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.48990840186212 0.0570863863112337 no 245 0.0681241610518832 535 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1249 0481-0015 10.2 µM 1.4886406660654 0.0572390092851515 no 246 0.0682910085116921 376 4227577 SGTC_3000 9075062 71.4286 µM 1.48791543769636 0.0573264639690017 no 247 0.0683865979475713 408 17057871 SGTC_2336 9001819 198.65 µM 1.4866647521882 0.0574775300621359 no 248 0.0685516882677306 473 2989602 SGTC_1859 st055998 20 µM 1.47775706809501 0.0585625348322347 no 249 0.06973640667867 458 676301 SGTC_712 r015-0009 80.6 µM 1.47683460435444 0.058675808763936 no 250 0.0698599890717888 382 6813872 YLR060W FRS1 SGTC_1379 2144-0755 36.5 µM 1.47552927391372 0.0588363905968018 no 251 0.0700351519880253 471 5392327 SGTC_71 0417-1750 47.813 µM 1.47018950253994 0.0594968831594938 no 252 0.0707552184992093 478 6811472 SGTC_2917 7979103 53.79 µM 1.467547757145 0.0598257904690151 no 253 0.071113553888584 505 2980565 SGTC_3083 9117465 49.47 µM 1.46475766020885 0.0601747128864554 no 254 0.0714935236124282 447 16420915 SGTC_1121 fusaric acid 630.51 nM 1.46158966153491 0.0605728239610206 no 255 0.0719268445710303 464 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_643 k048-0106 28.4 µM 1.45726604183871 0.0611194792762188 no 256 0.0725214783644388 436 6763920 SGTC_2018 5133068 143 µM 1.45365754336449 0.0615786638951841 no 257 0.0730206373175771 446 785362 SGTC_790 1575-0012 79.1 µM 1.45098986027212 0.0619198575557739 no 258 0.0733913418539102 460 378741 YLR208W SEC13 SGTC_2557 derrustone 83.84 µM 1.44945227559871 0.062117182114634 no 259 0.0736056594637372 503 629853 An antioxidant. SGTC_1691 st019933 84.6 µM 1.4439375590039 0.0628289456963499 no 260 0.074378270165799 429 6176082 SGTC_680 0417-1641 114 µM 1.44151165759848 0.0631440531811934 no 261 0.0747200931565431 420 2835990 SGTC_2724 maprotiline 69.64 µM 1.44026322179485 0.0633066951309015 no 262 0.074896471244751 435 4011 A tricyclic antidepressant. SGTC_447 ml7 120 µM 1.43786219650226 0.0636204090811187 no 263 0.0752365788705386 454 4216 Selective myosin light chain kinase inhibitor. SGTC_2081 5214970 32.255 µM 1.43741362322582 0.0636791527921752 no 264 0.0753002500580628 439 2063512 SGTC_1212 0520-0165 585 µM 1.42771556306898 0.0649595249186831 no 265 0.0766868723932091 472 5403258 SGTC_1058 3448-5425 97.3 µM 1.42236270210613 0.0656747382384896 no 266 0.0774604924644399 460 7279705 SGTC_862 0452-0056 10.2 µM 1.41927922432375 0.0660894943718407 no 267 0.0779088133124614 442 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_509 pifithrin 175 µM 1.41200740313003 0.0670756552618247 no 268 0.0789738906899152 430 4817 A p53 inhibitor. SGTC_2409 alverine citrate 63.97 µM 1.41166931246208 0.0671217804553448 no 269 0.079023676589603 495 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_254 nsc-64875 3.808 µM 1.40733266519651 0.0677155998655554 no 270 0.0796643837665494 456 56993 SGTC_1257 0669-0121 16 µM 1.40390824626109 0.0681873683849951 no 271 0.0801730868906721 543 4307855 SGTC_688 0527-0193 473 µM 1.40139388615221 0.0685353739366616 no 272 0.0805481597636972 454 4007154 SGTC_1587 estradiol valerate 56.1 µM 1.39967442944629 0.0687741468451976 no 273 0.0808054171978686 491 13791 A steroid. SGTC_2120 5538279 151.968 µM 1.38538872430302 0.0707828063640197 no 274 0.0829668184803262 475 2058197 SGTC_2735 sertaconazole 140 nM 1.38237281052969 0.0712125688341973 no 275 0.0834286300561625 407 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2977 9011197 71.43 µM 1.38175254526609 0.0713012034210472 no 276 0.0835238472077802 414 2704722 SGTC_1363 1636-0063 10.4 µM 1.37471198398172 0.0723132295770989 no 277 0.0846103772077693 524 6072185 SGTC_753 1322-0200 289 µM 1.37154959734367 0.0727713650027726 no 278 0.0851018467842578 495 5403907 SGTC_1502 4534-4282 27.7 µM 1.36885288606776 0.0731637907274543 no 279 0.0855226327354424 464 3278949 SGTC_399 oxolinic acid 75 µM 1.36845308201374 0.0732221078225671 no 280 0.0855851492365352 470 4628 A DNA gyrase inhibitor. SGTC_1336 1486-0901 104 µM 1.36661829574727 0.0734901936248248 no 281 0.0858724897401724 489 5006114 SGTC_1725 st036284 20.55 µM 1.36284963228068 0.0740431970898063 no 282 0.0864649526552008 552 707914 SGTC_1768 st044301 37.178 µM 1.36197692590357 0.0741717078417831 no 283 0.0866025835854344 517 3931349 SGTC_2997 9067075 71.4286 µM 1.3592237241748 0.0745782483567086 no 284 0.0870378528731763 553 27209819 SGTC_1282 0886-0010 32.4 µM 1.35886752911114 0.0746309684881721 no 285 0.087094284935396 578 2836211 YNL267W PIK1 SGTC_1486 3970-0793 4.53 µM 1.35677644077283 0.0749410425006146 no 286 0.087426127712752 502 2844330 SGTC_3103 9120822 49.47 µM 1.35308452640241 0.0754908903939564 no 287 0.0880143141900518 534 17141819 SGTC_2468 5987765 72.9 µM 1.35128507981591 0.0757599992775079 no 288 0.0883020647956938 508 26772094 SGTC_3015 9080845 49.47 µM 1.35113475183429 0.0757825139944482 no 289 0.0883261355310118 518 5296973 SGTC_2178 5812956 200 µM 1.35033127802508 0.0759029371962975 no 290 0.0884548718455352 465 5403383 SGTC_2023 5144124 124 µM 1.34911705369885 0.0760851993740586 no 291 0.088649685716059 505 2830192 SGTC_936 3005-4620 401 µM 1.34852413992995 0.0761743201787648 no 292 0.088744930661943 568 777207 SGTC_2404 5161160 200 µM 1.34843614981314 0.0761875527316428 no 293 0.0887590717784141 541 2831543 SGTC_48 0382-0018 55 µM 1.34813402398727 0.0762330017880506 no 294 0.0888076399642771 486 762596 SGTC_508 roscovitine 141 µM 1.33648866868721 0.0780005919627013 no 295 0.0906948008748222 509 160355 A CDKinase inhibitor. SGTC_2980 9014342 25.29 µM 1.33463837985225 0.0782842780763051 no 296 0.0909973651236714 500 2996599 SGTC_488 nitrendipine 139 µM 1.33027094530735 0.078956995075261 no 297 0.0917145082394006 557 4507 Dihydropyridine L-type calcium channel blocker. SGTC_600 1495-0418 41.6 µM 1.32809220489061 0.0792942197653253 no 298 0.0920738241541719 495 5377768 SGTC_2643 anethole 100 µM 1.32711742562191 0.0794454483295838 no 299 0.0922349209303274 538 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_153 4077-0274 519.67 µM 1.32475449787795 0.0798129418923455 no 300 0.0926262955682306 478 3121976 SGTC_934 2950-0684 338 µM 1.32097260074415 0.0804037938067762 no 301 0.0932552501069797 574 1121253 SGTC_34 0469-0683 81.75 µM 1.31656491504326 0.0810965771873187 no 302 0.0939922528345145 517 3690923 SGTC_2414 st077232 92.9 µM 1.31563932754746 0.0812426281549954 no 303 0.0941475635556204 526 729801 SGTC_553 k007-0256 45.7 µM 1.31328792016403 0.081614555476445 no 304 0.0945429737289803 551 6287000 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.31312530886529 0.0816403234477938 no 305 0.0945703634649629 511 641818 YHR062C RPP1 SGTC_2344 7990960 76.95 µM 1.31247218218298 0.0817438820478682 no 306 0.0946804330016173 496 140813 SGTC_363 0455-0021 3.06 µM 1.31111220335463 0.0819598355769785 no 307 0.0949099292207631 565 4597466 SGTC_985 1493-0307 8.71 µM 1.31080758553776 0.0820082652745109 no 308 0.0949613895640921 465 3278274 SGTC_127 0180-0333 59.125 µM 1.31039503730785 0.0820738886711621 no 309 0.0950311158023867 637 771601 SGTC_1311 1190-0148 100 µM 1.3099720509162 0.0821412135171665 no 310 0.0951026453787786 646 1961333 SGTC_2911 7942208 15.64 µM 1.30878725729875 0.0823300132543482 no 311 0.0953032122764262 476 1243384 SGTC_1953 st076800 12.1 µM 1.30787325858719 0.0824758843101961 no 312 0.0954581505219302 572 297591 SGTC_2133 5320837 200 µM 1.3060855574349 0.0827617576129176 no 313 0.0957617319209542 494 2841355 SGTC_821 1114-0266 29.2 µM 1.30576069228943 0.0828137871261763 no 314 0.0958169756053933 518 3123235 SGTC_1002 4049-0206 172 µM 1.29172361200998 0.0850855042749108 no 315 0.0982264386883506 603 4662749 SGTC_315 k915-0449 187 µM 1.28993224749079 0.0853787413854844 no 316 0.0985370915515968 638 20970215 YNL149C PGA2 SGTC_1978 st071761 42 µM 1.28892136932284 0.0855445506917182 no 317 0.0987127120579512 518 5147680 SGTC_802 4112-3352 742 µM 1.28872206535551 0.0855772699665385 no 318 0.0987473642813763 619 704594 SGTC_2314 7727897 200 µM 1.2880775347125 0.0856831452366539 no 319 0.0988594873194456 531 900724 SGTC_325 2810-4341 181 µM 1.28456041414815 0.086262621137986 no 320 0.0994729696511421 551 774970 SGTC_78 0336-0123 156.75 µM 1.28179845898463 0.086719727832884 no 321 0.0999566774676806 506 6765896 SGTC_2190 6049624 200 µM 1.28054436019044 0.0869278791692715 no 322 0.100176876960231 478 2265554 SGTC_479 n-linoleoylglycine 10 µM 1.27943134139695 0.0871129269170244 no 323 0.10037260150506 515 6433346 An anti-infammatory. SGTC_2481 5478948 45.16 µM 1.27289613767065 0.0882053922464752 no 324 0.101527449999334 555 77792 SGTC_1405 3909-7894 12 µM 1.27260485883297 0.0882543208827405 no 325 0.101579146782946 568 7104060 SGTC_703 3875-0075 71.8 µM 1.27024416711538 0.0886516133441011 no 326 0.101998834716435 592 2850814 SGTC_463 ikarugamyin 104 µM 1.26650890348717 0.0892829583405748 no 327 0.102665471924048 487 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2091 4-phenylthiadiazole 200 µM 1.26546976945767 0.0894591890961084 no 328 0.102851489278939 585 270010 SGTC_1131 3454-3128 32.3 µM 1.26415606055527 0.0896823561989136 no 329 0.103087009151389 612 710982 SGTC_1431 4049-0260 9.09 µM 1.26343468360085 0.0898050764603034 no 330 0.103216503071466 565 3854841 SGTC_560 2332-1943 155 µM 1.26328511288653 0.0898305369666598 no 331 0.103243367193355 568 21177716 SGTC_2367 9070478 135.38 µM 1.26183036659163 0.0900784494353793 no 332 0.103504916362389 597 572802 SGTC_1084 voriconazole 435 nM 1.26043853418923 0.090316115836591 no 333 0.10375560405116 567 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1448 4255-0083 152 µM 1.25913706093242 0.0905387737362862 no 334 0.103990415075063 582 5399660 SGTC_2305 7443522 69.23 µM 1.25616394640828 0.0910489467271272 no 335 0.104528267720823 600 5415886 SGTC_760 0568-0725 82.9 µM 1.25335695008217 0.0915325685581772 no 336 0.105037915588478 606 3916171 SGTC_587 k089-0003 57 µM 1.25307769741628 0.0915807853626915 no 337 0.105088715856109 422 9659696 SGTC_3025 9087895 49.47 µM 1.25095805219881 0.091947384972404 no 338 0.105474891073307 625 17173641 SGTC_482 fipronil 114 µM 1.24804597312205 0.0924528092314888 no 339 0.106007110888107 509 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2170 morpholine 200 µM 1.24730758450065 0.0925812910194714 no 340 0.106142368754854 582 121171 Reacts with secondary amines. SGTC_2297 7971671 152.32 µM 1.24474089593866 0.0930289299090827 no 341 0.106613504031645 566 909016 SGTC_173 1273-0061 2.693 µM 1.24412264950383 0.0931369928085965 no 342 0.106727213127569 622 2847414 YPL266W DIM1 SGTC_342 k048-0088 23.3 µM 1.24274622384776 0.0933779104903852 no 343 0.106980682304211 578 6820570 SGTC_1136 pergolide 1.05886 µM 1.24228081341219 0.0934594759789643 no 344 0.107066485926475 679 47811 A dopamine receptor agonist. SGTC_1347 1493-0251 600 nM 1.23758934616933 0.0942846195268149 no 345 0.107934183395652 636 3986378 SGTC_1329 1447-1697 50.6 µM 1.23652652587811 0.0944722944958658 no 346 0.108131456015493 602 2840515 SGTC_965 1291-5240 308 µM 1.23547497803094 0.0946582498830134 no 347 0.108326891644052 613 2834598 SGTC_1624 st003710 6.25 µM 1.23406533566825 0.0949079536443495 no 348 0.108589279597743 650 24207033 SGTC_2757 clomiphene 4.22 µM 1.22541513487982 0.0964508820934699 no 349 0.110209423662202 686 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1680 diphenhydramine 100 µM 1.22443587439319 0.096626706606541 no 350 0.11039392153284 591 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1342 1486-1464 234 µM 1.22054614878137 0.0973274250948425 no 351 0.111128953167867 634 3253938 SGTC_306 1672-3436 11.6 µM 1.22054380626284 0.0973278482104556 no 352 0.11112939688105 626 6797378 SGTC_3132 9126706 49.47 µM 1.22037732965766 0.0973579213755139 no 353 0.111160933653945 573 850858 SGTC_1703 st026983 48.3 µM 1.22023939188328 0.0973828443074202 no 354 0.111187068980125 642 1104023 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.21615563414675 0.0981228293968862 no 355 0.111962820350733 622 688664 SGTC_696 1560-0013 611 µM 1.21230192506211 0.0988248993977792 no 356 0.112698413631132 624 1650269 SGTC_1284 0929-0043 16 µM 1.21182507459315 0.0989120270859407 no 357 0.112789673895001 626 1239883 SGTC_2020 4017018 200 µM 1.20857393141199 0.0995075575837521 no 358 0.113413288286117 604 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2442 5158906 48.48 µM 1.20741685516375 0.0997201368979778 no 359 0.113635823796034 627 1893835 SGTC_476 mead acid 10 µM 1.20708105681167 0.0997818922107499 no 360 0.113700464692666 536 5312531 An omega 9 fatty acid. SGTC_615 k087-0205 167 µM 1.20514807700428 0.100137922031725 no 361 0.114073071376449 593 9642773 SGTC_983 1491-0821 12.2 µM 1.20410647165059 0.10033015632934 no 362 0.114274214449984 598 46495113 SGTC_324 1315-0088 19.6 µM 1.20341615310098 0.10045770692214 no 363 0.114407660060677 530 6787421 SGTC_1688 st021091 57.6 µM 1.20117410381495 0.100872787894297 no 364 0.114841836224254 611 3656366 SGTC_1726 st035556 14.5795 µM 1.20004919844482 0.101081517322707 no 365 0.11506011685181 671 5919439 SGTC_245 methotrexate 289.6 µM 1.19682047007168 0.101682365275474 no 366 0.115688268915302 679 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1068 loratadine 26.9 µM 1.19220472298804 0.10254583929321 no 367 0.116590490987501 595 3957 A H1 histamine antagonist. SGTC_1396 3511-0007 98.6 µM 1.19173342321284 0.10263430501235 no 368 0.11668289410267 561 X1396 SGTC_3299 9121982 43.1275 µM 1.19133532316888 0.102709073923382 no 369 0.116760986111254 628 17594604 YPL160W CDC60 SGTC_81 0411-0046 9.971 µM 1.19125453100759 0.102724252683667 no 370 0.116776838966287 576 12925265 SGTC_1172 0370-0043 85 µM 1.19019702622928 0.102923080857912 no 371 0.11698448086927 602 376585 SGTC_326 k292-0812 17.5 µM 1.18817453906705 0.103304119886135 no 372 0.117382326244758 608 3579357 SGTC_1552 6-methylflavone 10.6 µM 1.1861914939806 0.103678721380638 no 373 0.117773342307865 576 689013 SGTC_327 1273-0057 3.96 µM 1.18611867166019 0.10369249641031 no 374 0.117787718910009 594 3108138 SGTC_3032 9089427 49.47 µM 1.1837274323608 0.104145559835483 no 375 0.11826048809543 596 17173707 SGTC_2224 6650123 117.647 µM 1.18313878344811 0.104257309783494 no 376 0.118377074707092 593 2908370 SGTC_3309 9129340 25.759 µM 1.18296294342259 0.104290708356981 no 377 0.118411916981465 678 17158987 SGTC_510 ag-490 170 µM 1.17699702814995 0.105428456504478 no 378 0.119598346211961 680 5328779 SGTC_761 k216-0224 480 µM 1.17541248596771 0.105732144830134 no 379 0.119914865281861 685 1340404 SGTC_2157 5649910 96.377 µM 1.17500154865602 0.105811006941507 no 380 0.119997048110202 653 2858091 SGTC_150 3970-0969 77.2 µM 1.17356523509237 0.106086980839624 no 381 0.120284606473386 724 6615640 SGTC_1393 3470-5649 58.2 µM 1.17157804563989 0.106469657178252 no 382 0.120683253343053 535 4108395 SGTC_657 3534-0529 86.7 µM 1.16906875315198 0.106954298253185 no 383 0.121187965988928 649 1049549 SGTC_418 lividomycin a 100 µM 1.16901596145045 0.106964511429489 no 384 0.121198600297804 695 72394 An antibiotic. SGTC_197 4544-0043 41.561 µM 1.16542877240927 0.107660144291615 no 385 0.121922738174781 682 896523 SGTC_1244 0416-0015 52.5 µM 1.16197685842274 0.10833261617227 no 386 0.122622432566355 630 96201 SGTC_83 0170-0301 39.027 µM 1.16165717496722 0.108395046717921 no 387 0.122687373840241 547 3089716 SGTC_2093 5331342 194.4 µM 1.16150805195542 0.108424177600185 no 388 0.122717675301298 666 33839 SGTC_2267 7931562 200 µM 1.15961845162137 0.108793795254161 no 389 0.123102092573868 581 934880 SGTC_32 0928-0142 34.1 µM 1.15935774783231 0.108844861585498 no 390 0.123155195922877 615 2244242 SGTC_2731 amoxapine 43.43 µM 1.15871702759114 0.108970438281637 no 391 0.123285773898155 541 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_992 3909-8734 162 µM 1.15690144133976 0.109326846100995 no 392 0.123656314898167 641 4288319 SGTC_3084 9116877 49.47 µM 1.15568794938113 0.10956552649992 no 393 0.123904409510504 593 27241325 SGTC_3258 9138477 49.47 µM 1.15544894152403 0.109612580764855 no 394 0.123953314952463 651 4970355 SGTC_1749 st037932 54.2 µM 1.15289172426457 0.110116936860685 no 395 0.124477414643789 618 594497 SGTC_1951 sophoraflavanone G 9.2 µM 1.15218906711041 0.110255811977264 no 396 0.124621694646509 694 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3302 9125395 16.351 µM 1.14951269598219 0.110785927735834 no 397 0.125172317328643 653 17599668 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.14493574554901 0.111696723640735 no 398 0.126117887637993 750 551469 SGTC_1553 gossypol 38.6 µM 1.14459004520103 0.111765733644144 no 399 0.126189508956816 551 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1234 0326-0494 15.5 µM 1.14318552156806 0.112046423577073 no 400 0.126480786140387 668 1547813 SGTC_2071 5230951 39.92 µM 1.1430164709067 0.112080241805935 no 401 0.126515876272855 707 1799272 SGTC_2319 6033012 152.6 µM 1.14166409944612 0.112351043562864 no 402 0.126796834442079 605 847246 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.13990560656686 0.112703866690153 no 403 0.127162814508207 686 5379071 SGTC_3288 9119690 36.221 µM 1.13967393091579 0.112750408896881 no 404 0.12721108591757 607 17595618 YKL019W RAM2 SGTC_2811 7967822 32.47 µM 1.13729164132101 0.113229792403379 no 405 0.127708193928609 668 2232244 SGTC_806 3966-4455 5.86 µM 1.13550495892542 0.113590276017546 no 406 0.128081902669429 597 714982 SGTC_3214 9129694 49.47 µM 1.1345683569024 0.113779572745076 no 407 0.128278108806562 645 17158655 SGTC_678 1218-2179 85.9 µM 1.13158193576398 0.114384659708087 no 408 0.12890511908558 622 6820081 YOR116C RPO31 SGTC_940 3232-1287 54.8 µM 1.13062754189057 0.114578514263529 no 409 0.129105945106114 697 1585493 YIL048W NEO1 SGTC_1491 4138-0063 26.5 µM 1.12499764650673 0.115726805648495 no 410 0.130295015787728 649 23883227 SGTC_2353 9059630 146.67 µM 1.11853354680202 0.117055295974608 no 411 0.131669593595941 662 4779114 SGTC_1462 k081-0014 26.5 µM 1.11599042769481 0.1175809040029 no 412 0.132213116018316 530 3270634 SGTC_2051 5263410 176 µM 1.11250958434866 0.1183030246345 no 413 0.132959555791678 725 227584 SGTC_3156 9099931 49.47 µM 1.11162229963061 0.11848759729844 no 414 0.133150290226242 726 18111053 SGTC_1720 st037298 9.481 µM 1.10857682641503 0.119122663415373 no 415 0.133806389829827 665 597396 SGTC_2927 9011802 47.9 µM 1.10652612453884 0.119551643467194 no 416 0.13424943147078 673 43912568 SGTC_3107 9121808 49.47 µM 1.10493912950025 0.119884369256626 no 417 0.13459298287992 640 662681 SGTC_2658 polymyxin b sulfate 77.05 µM 1.104543608599 0.11996739480381 no 418 0.134678698781303 718 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3250 9135583 49.47 µM 1.10447892700052 0.119980976260243 no 419 0.134692719913644 671 7699353 SGTC_1283 0922-0125 16.4 µM 1.10258664849587 0.120378785343379 no 420 0.135103355484582 745 3360884 SGTC_2511 berberine 10.47 µM 1.09890613138324 0.121155190229094 no 421 0.135904505984775 705 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3209 9113616 49.47 µM 1.09731066752514 0.121492845275299 no 422 0.136252804617994 754 16649353 SGTC_539 4859-0462 2.54 µM 1.09231436092961 0.122554513087347 no 423 0.137347475125177 725 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_681 1642-0006 26.6 µM 1.09099920410767 0.122835050417889 no 424 0.137636616400013 699 4446530 SGTC_1246 0422-0085 105 µM 1.08561363761928 0.123988547284446 no 425 0.138824981811839 750 264295 SGTC_2394 5221648 200 µM 1.08346791526621 0.124450229669335 no 426 0.139300392334367 813 788586 SGTC_1224 0823-0416 294 µM 1.08092343342364 0.124999266969718 no 427 0.139865586927361 740 3598164 SGTC_1228 0124-0032 52.5 µM 1.08060484484884 0.125068129637408 no 428 0.139936463251278 731 X1228 SGTC_499 genistein 192 µM 1.0792686713415 0.125357231061648 no 429 0.140233987281284 697 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2270 7924575 90.91 µM 1.07683442069235 0.125885116534134 no 430 0.140777122432069 757 1262135 SGTC_1619 st003326 88.7 µM 1.07617514229941 0.12602835239811 no 431 0.140924467331054 683 2849032 SGTC_400 oxethazaine 37.5 µM 1.07592541316515 0.126082638606095 no 432 0.140980307653599 699 4621 A local anesthetic. SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.0756447849916 0.126143661108055 no 433 0.141043075016848 700 6708514 SGTC_484 loperamide 105 µM 1.07524167442839 0.126231353386539 no 434 0.141133270853792 616 3955 An opioid-receptor agonist. SGTC_918 glabranin 770.725 nM 1.07151926486174 0.127043130610584 no 435 0.141968006604776 728 124049 Also referred to as licorice root. SGTC_1312 1218-2183 165 µM 1.07086692189429 0.12718576583919 no 436 0.142114635459322 771 6744073 SGTC_1035 k081-0041 55.2 µM 1.07035619363141 0.127297514653239 no 437 0.142229504716572 760 731709 SGTC_2222 6885208 172.143 µM 1.06985533629715 0.127407169994132 no 438 0.142342214879386 704 609514 SGTC_2714 st079313 56.9 µM 1.06894635808761 0.127606345153684 no 439 0.142546920614152 714 2939799 SGTC_486 niguldipine 82 µM 1.06865252392634 0.127670776321779 no 440 0.14261313586923 680 1236 A calcium channel blocker. SGTC_1741 st038134 10.228 µM 1.06460835079684 0.128559869828959 no 441 0.143526599631892 781 1272587 SGTC_1266 0828-0227 32.9 µM 1.06256479922947 0.129010766089827 no 442 0.143989678705979 697 3913820 SGTC_2909 7941780 10.49 µM 1.06101472647074 0.129353510054148 no 443 0.144341604337514 766 1243215 SGTC_2516 gossypol 71.55 µM 1.05768652684804 0.130091554747364 no 444 0.145099189859278 775 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1395 3486-0190 4.35 µM 1.057475465175 0.130138456786568 no 445 0.145147323102494 796 6748079 SGTC_971 1315-0384 26.7 µM 1.05534981868041 0.1306114694977 no 446 0.145632682150134 718 6769120 SGTC_885 0865-0106 16.8 µM 1.05397002795951 0.130919145018724 no 447 0.145948319779765 742 2793380 SGTC_2162 5663267 200 µM 1.05305975096151 0.131122399030946 no 448 0.146156804052117 785 6456493 SGTC_2857 9024691 58.44 µM 1.0513787513856 0.131498318925374 no 449 0.146542335468281 710 16478292 SGTC_2964 9083345 53.42 µM 1.05037005054767 0.131724250284986 no 450 0.146774004890356 679 17741579 SGTC_2526 patulin 37.61 µM 1.04748883528183 0.132371066784604 no 451 0.147437089411409 795 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_220 paclitaxel 373.376 µM 1.04744735197835 0.13238039550839 no 452 0.147446651037291 673 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_604 1000-0114 314 µM 1.0457245878108 0.132768209156987 no 453 0.147844103659029 829 1572745 SGTC_1865 st057639 52.2 µM 1.04428291740774 0.133093346217822 no 454 0.148177256969453 755 688818 SGTC_1081 sertraline 6 µM 1.04361513208739 0.133244136077431 no 455 0.148331744507082 779 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_755 1995-0008 37.3 µM 1.04357194319702 0.133253892428904 no 456 0.148341739667581 788 689533 SGTC_223 busulfan 5 mM 1.04181345524305 0.133651551583563 no 457 0.148749087337746 681 2478 A DNA alkylator. SGTC_987 1497-1013 404 µM 1.04143237147146 0.133737836177578 no 458 0.148837462551628 732 1676435 SGTC_3115 9123671 49.47 µM 1.0412894226388 0.133770212379128 no 459 0.148870622141451 799 3286988 SGTC_3048 9093155 49.47 µM 1.0394383352533 0.134189948183309 no 460 0.149300461476562 686 25236002 SGTC_1301 naphtanilide LB 4.81 µM 1.03863879310662 0.134371524581304 no 461 0.149486378441167 822 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1811 st050069 61.5 µM 1.03860450511004 0.134379315172325 no 462 0.149494354858387 747 3877702 SGTC_795 0685-0265 78 µM 1.03831525120246 0.134445049026122 no 463 0.149561655305696 791 302754 SGTC_1019 4262-0212 3.4 µM 1.03819062589834 0.134473377319413 no 464 0.149590657994793 823 4677213 SGTC_1956 st077085 54 µM 1.0379201072464 0.134534882397171 no 465 0.14965362576708 794 24208685 SGTC_942 3253-1115 227 µM 1.03586079481482 0.135003720354025 no 466 0.150133545089434 775 46497897 SGTC_931 2812-0076 566 µM 1.03485230522979 0.135233728668571 no 467 0.150368945727917 781 3450959 SGTC_2618 avocadyne 43.43 µM 1.03259525980816 0.135749470715034 no 468 0.150896673703654 755 3015189 SGTC_3201 9113999 49.47 µM 1.03242621012069 0.135788153261256 no 469 0.150936249389598 735 16649224 SGTC_1912 st060209 90.8 µM 1.03210142848086 0.135862492124818 no 470 0.151012302373184 720 688787 SGTC_1555 citronellol 128 µM 1.03184873760376 0.135920349496618 no 471 0.151071491750763 742 8842 A terpine precursor. SGTC_3333 9141820 12.094 µM 1.03093600684292 0.136129473419034 no 472 0.15128541499916 709 1939433 SGTC_1796 st049173 110.4 µM 1.03081257906364 0.136157769957819 no 473 0.151314359110192 726 94134 SGTC_1495 4469-0029 237 µM 1.03080321641589 0.136159916563708 no 474 0.151316554823878 870 793680 SGTC_1920 st075728 45.7 µM 1.0292907653837 0.136506985427363 no 475 0.151671530718554 760 3400306 SGTC_1310 1188-0297 994 nM 1.02743472100576 0.136933726409986 no 476 0.152107904569765 777 1588352 SGTC_1191 1487-1166 10.6 µM 1.02405803647823 0.137712428402284 no 477 0.152903931703506 864 3955771 SGTC_1603 st002045 67.8 µM 1.02371272506626 0.137792231135149 no 478 0.152985491584277 797 5887985 SGTC_2455 5377712 9.75 µM 1.02292771188274 0.137973767943423 no 479 0.153171012911161 693 2243908 SGTC_139 0099-0334 718.624 µM 1.01844811570725 0.139012809787387 no 480 0.154232522988949 909 97690 SGTC_358 0075-0058 9.45 µM 1.01785716134351 0.139150278261693 no 481 0.154372921216239 858 1069125 SGTC_2485 5633444 17.78 µM 1.01630913587715 0.139510820206099 no 482 0.154741099729082 753 5724239 SGTC_1032 k061-1018 98.7 µM 1.01464873454192 0.139898240631116 no 483 0.155136649790519 875 4005393 SGTC_433 pimozide 108 µM 1.00998685107436 0.140989900781338 no 484 0.156250794881742 647 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1718 roemerine 11.9335 µM 1.00967716670643 0.141062622794943 no 485 0.156324992699138 797 235224 An aporphine alkaloid with mutagenic activity. SGTC_2998 9066762 71.4286 µM 1.00922439497724 0.141168991250529 no 486 0.15643351482931 808 4945196 SGTC_2897 9048598 12.99 µM 1.0088137658413 0.141265506273413 no 487 0.156531978945197 748 6467404 SGTC_1163 k060-0048 49.9 µM 1.00664376245122 0.141776290551723 no 488 0.157052998121386 820 6809982 SGTC_1974 st069448 26.9 µM 1.00422975281447 0.14234597802176 no 489 0.157633942097946 786 6323587 YNR016C ACC1 SGTC_1146 3579-1023 7 µM 1.00344557063266 0.142531371702767 no 490 0.157822963039266 879 X1146 SGTC_3013 9080133 71.4286 µM 1.00206917416596 0.142857169363796 no 491 0.158155092355611 862 17050193 SGTC_1480 1070-0044 41.2 µM 1.00203051183278 0.142866328129744 no 492 0.158164428331815 808 3124987 SGTC_2291 7917025 104.35 µM 1.00153176837161 0.142984511640001 no 493 0.158284894698363 780 2964612 SGTC_2945 9067681 61.76 µM 1.00113524178829 0.143078520708367 no 494 0.158380714576186 770 16456930 SGTC_2616 abietic acid 100 µM 0.99949942340041 0.143466784183409 no 495 0.158776409130077 844 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2682 pyrogallin 40.03 µM 0.997492021030625 0.143944214739726 no 496 0.159262872411866 854 822798 An ATP competetive kinase inhibitor. SGTC_1556 plumbagin 1.48 µM 0.996897503979638 0.144085817160802 no 497 0.159407131681825 749 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_787 4152-0075 138 µM 0.995377154318116 0.144448362067284 no 498 0.159776432783372 779 9566539 SGTC_2103 5378138 10 µM 0.995355574137968 0.144453512530765 no 499 0.159781678750813 892 244142 SGTC_2304 7443016 91.4 µM 0.993528797247066 0.144889951404224 no 500 0.160226161953985 740 939854 SGTC_2417 cerulenin 830 nM 0.992743652820413 0.145077804322541 no 501 0.160417447892635 793 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3161 9100388 49.47 µM 0.990602115501706 0.145591019561052 no 502 0.160939952150261 857 25236368 SGTC_2164 5685496 200 µM 0.990464352748189 0.145624075875283 no 503 0.160973602264503 813 759046 SGTC_3221 9128209 49.47 µM 0.989557994772608 0.145841683212378 no 504 0.161195104957757 772 16460723 SGTC_2438 5259590 200 µM 0.989000658405997 0.145975602465848 no 505 0.161331409766813 852 1201127 SGTC_3337 9144342 33.5465 µM 0.987463741088555 0.146345327747934 no 506 0.161707674875603 833 17682949 SGTC_1287 0971-0001 34.6 µM 0.985552327901024 0.146806019365293 no 507 0.162176420643084 853 4665869 SGTC_401 neomycin 50 µM 0.984261467385931 0.147117694271834 no 508 0.162493485074573 795 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.983931176030227 0.147197513485882 no 509 0.162574676840928 801 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_323 4013-0906 34.3 µM 0.982549338736806 0.14753176723785 no 510 0.16291464434167 844 2910086 SGTC_3127 9126946 49.47 µM 0.981647009995152 0.1477503064935 no 511 0.163136889694785 727 27243249 SGTC_322 k048-0136 19.3 µM 0.980547820560759 0.148016817110661 no 512 0.163407888308415 772 6823282 SGTC_2333 9017922 200 µM 0.980227029176985 0.148094657140504 no 513 0.163487032605543 819 3163164 SGTC_85 0868-0259 160.055 µM 0.978943331362548 0.148406420523919 no 514 0.163803990205501 780 83173 SGTC_520 3584-0023 682 µM 0.97864606460706 0.148478678325623 no 515 0.16387744512211 767 1340790 SGTC_2214 7179297 48.276 µM 0.978591050904347 0.148492053302575 no 516 0.163891041407475 831 769744 SGTC_3347 9188721 44.724 µM 0.978309663426654 0.14856047705812 no 517 0.163960595972972 790 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.978049568092527 0.148623742042317 no 518 0.164024904486124 778 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2991 9074669 71.4286 µM 0.975010051046358 0.149364402137418 no 519 0.164777637144826 862 17333109 SGTC_2465 5809242 33.21 µM 0.971631558457877 0.150190549622725 no 520 0.16561693835799 849 2731748 SGTC_1692 fluoroquinolonic acid 71 µM 0.969762154665788 0.150648983961332 no 521 0.166082530535767 813 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1439 4092-1168 46 µM 0.968614365085014 0.15093091791921 no 522 0.166368816672853 847 2886240 SGTC_2457 5731572 11.68 µM 0.9685996527917 0.150934534008708 no 523 0.166372488337428 851 2865357 SGTC_2529 gangaleoidin 93.61 µM 0.968551672435917 0.150946327354024 no 524 0.16638446288944 849 4565183 SGTC_376 3970-0862 59.1 µM 0.965618259998509 0.151668511313859 no 525 0.167117617388758 859 3135186 SGTC_2062 5245942 200 µM 0.963777199755924 0.152122937469481 no 526 0.167578820025464 900 1376160 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.962546769532486 0.152427146272798 no 527 0.16788751082287 894 676296 Flavone; oxidizing agent. SGTC_2839 9003951 25.97 µM 0.960638615742227 0.152899711957932 no 528 0.168366952691525 819 2990634 SGTC_749 1000-0129 128 µM 0.960047505067218 0.153046300918666 no 529 0.168515653358088 887 708470 SGTC_1809 st050081 57.6 µM 0.958893752657891 0.15333268714293 no 530 0.168806136165745 839 5036894 SGTC_219 mitoxanthrone 164.414 µM 0.958101212462149 0.153529618284167 no 531 0.169005862075876 792 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2826 7992541 19.48 µM 0.95698555165854 0.153807122481195 no 532 0.169287273841699 813 2985066 SGTC_3194 9111903 49.47 µM 0.955262048798768 0.154236470651929 no 533 0.169722597214528 815 17087251 SGTC_3304 9125678 46.087 µM 0.954990019278268 0.154304309288604 no 534 0.169791372137564 824 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2234 tolnaftate 200 µM 0.954311119483718 0.154473699161435 no 535 0.169963090575882 827 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2385 9074692 200 µM 0.954029576852824 0.154543981906555 no 536 0.170034335588464 853 17046906 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.945982139943063 0.156561835021183 no 537 0.172078847900154 817 688803 SGTC_881 0833-0569 170 µM 0.944794148002645 0.156861180613282 no 538 0.1723819900403 824 5418700 SGTC_2877 9040724 71.43 µM 0.940689837122162 0.157898265103569 no 539 0.17343191428331 877 6463895 SGTC_1435 4092-0789 56.7 µM 0.939750689970115 0.158136202015928 no 540 0.173672728696942 876 2248285 SGTC_831 k061-1017 217 µM 0.938865554879093 0.158360670051291 no 541 0.17389988807273 1002 1240153 SGTC_2117 5521686 200 µM 0.938529342159318 0.158445987505946 no 542 0.173986222554087 828 803312 SGTC_379 3970-0972 5.9 µM 0.937909958745455 0.158603241373885 no 543 0.174145342436898 850 2898042 YBL034C STU1 SGTC_1941 st076221 61.8 µM 0.937647191962355 0.158669985552166 no 544 0.174212875278429 898 2828568 SGTC_1211 1056-0033 32.3 µM 0.936332752988663 0.159004136563789 no 545 0.174550944804022 910 6741922 SGTC_2364 9055074 200 µM 0.93447475588398 0.159477254534021 no 546 0.175029525920038 813 6470630 SGTC_1160 4092-0570 10.5 µM 0.934423145064733 0.159490409787416 no 547 0.175042831658056 864 4994975 SGTC_1101 ebselen 5.29 µM 0.932901161637508 0.159878672547686 no 548 0.175435501277634 950 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1928 4'-methoxychalcone 40.3 µM 0.932249782489231 0.160045030180253 no 549 0.175603726693415 908 641818 SGTC_2019 4016004 108 µM 0.931576265627195 0.160217160609037 no 550 0.17577777685699 798 45595336 SGTC_2471 5466956 24.79 µM 0.931570988462953 0.160218509769362 no 551 0.175779141012596 856 724419 SGTC_3348 9149464 3.537 µM 0.930530161424427 0.160484752887044 no 552 0.176048327601903 875 1951442 SGTC_3336 9143619 71.43 µM 0.92975955299761 0.160682060317499 no 553 0.176247796256325 924 45595730 SGTC_3053 9095903 49.47 µM 0.929039388990606 0.160866595046927 no 554 0.176434336826352 913 17174018 SGTC_714 4296-0578 26.1 µM 0.927999343589484 0.161133340226417 no 555 0.176703955057554 866 1589775 SGTC_159 3970-0959 50 µM 0.927610430355343 0.161233160669376 no 556 0.176804842632955 1049 6615653 SGTC_2355 9061122 103.12 µM 0.927018199247 0.161385243179167 no 557 0.176958542608271 883 5302957 SGTC_3249 9135183 49.47 µM 0.925106142737384 0.161876889805708 no 558 0.177455349062055 918 4902779 SGTC_2947 9072639 7.68 µM 0.924727642934373 0.161974328951853 no 559 0.177553798331948 968 16488146 SGTC_122 0236-0016 402.397 µM 0.921926006177939 0.162696756427964 no 560 0.178283586482528 948 6808838 SGTC_603 3794-0023 45.9 µM 0.920832411734006 0.162979317540521 no 561 0.178568965117069 878 3802260 SGTC_3298 9116858 71.43 µM 0.917813570594005 0.163760975512316 no 562 0.179358238169636 905 2506942 SGTC_364 0083-0097 67.7 µM 0.917374454394841 0.163874876720805 no 563 0.179473227132455 870 5207356 SGTC_2303 7774051 200 µM 0.916063013366993 0.164215353967921 no 564 0.179816922831369 856 2953184 SGTC_248 streptozotocin 5.23457 mM 0.916054794450748 0.164217489214273 no 565 0.179819078105378 929 5300 DNA alkylating agent. SGTC_2121 5257820 149.641 µM 0.915111218020776 0.16446274683345 no 566 0.180066623185797 958 791256 SGTC_2 0422-0095 29 µM 0.913989663367213 0.164754573822391 no 567 0.180361138584477 782 6790840 SGTC_2720 fluspirilene 36.88 µM 0.913366990335007 0.164916737223836 no 568 0.180524780234252 815 3396 An atypical antipsychotic. SGTC_2635 hydroquinidine 100 µM 0.909144389646414 0.166019159727545 no 569 0.18163695693823 887 442912 An experimental heart treatment. SGTC_2895 9054447 58.44 µM 0.908895924232366 0.166084176254647 no 570 0.181702532710361 889 2697450 SGTC_1377 2944-0135 198 µM 0.90857844217599 0.166167276464362 no 571 0.18178634512423 925 1894137 SGTC_1758 st042942 75.2445 µM 0.907108025613918 0.166552504876205 no 572 0.182174837209661 898 669317 SGTC_2844 9010103 25.97 µM 0.906968356298325 0.16658912622312 no 573 0.182211765573514 849 2480525 SGTC_654 1124-0271 80.9 µM 0.906886036436454 0.166610712955875 no 574 0.182233533016458 902 5403748 SGTC_2134 5324836 1.464 µM 0.904791678652642 0.1671605234702 no 575 0.182787880465408 839 699272 SGTC_2762 leflunomide 42.06 µM 0.904466999700703 0.167245862748074 no 576 0.182873912627079 921 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1364 1653-0028 37.6 µM 0.903480272754449 0.167505388397323 no 577 0.183135526759945 878 5718652 SGTC_2040 5100729 123 µM 0.90214174986643 0.167857856709677 no 578 0.183490786631594 918 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_798 1287-0182 476 µM 0.900653581054129 0.16825029084616 no 579 0.183886268219411 983 1649755 SGTC_2110 5483698 200 µM 0.897327932945223 0.169129404500859 no 580 0.184771977739911 895 2848765 YHR062C RPP1 SGTC_190 3970-0790 3.722 µM 0.896563283190034 0.169331951049751 no 581 0.184975998885383 888 2832352 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.896044816645178 0.169469375156565 no 582 0.185114413895554 943 94937 An inhibitor of serotonin biosynthesis. SGTC_101 0490-5701 117.494 µM 0.895711868611061 0.169557663679993 no 583 0.185203334944682 855 4661669 SGTC_1 0258-0098 57.368 µM 0.894656645712759 0.169837674263688 no 584 0.18548533050635 799 6790032 YDR047W HEM12 SGTC_647 0140-0236 81 µM 0.894602881106905 0.169851949002142 no 585 0.185499705578804 998 990837 SGTC_3276 9139060 49.47 µM 0.893744551472353 0.170079943450551 no 586 0.18572929127377 903 4870619 SGTC_1356 1502-0781 85.8 µM 0.892692754045092 0.170359595233339 no 587 0.1860108658936 889 567702 SGTC_2979 9012552 45.46 µM 0.892070047983665 0.170525298974982 no 588 0.186177693966246 877 17100905 SGTC_1690 st023502 41.2 µM 0.890465776006518 0.170952675275359 no 589 0.186607918625285 905 24207482 SGTC_2017 5132927 60.65 µM 0.889542754499927 0.17119887747363 no 590 0.186855728098641 938 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_706 4262-0057 46.9 µM 0.889314412073632 0.171259819370288 no 591 0.186917064055073 918 883298 SGTC_2490 carminic acid 95.39 µM 0.88859989890285 0.171450604088112 no 592 0.187109072716182 867 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_375 3970-0961 9.27 µM 0.887958571420994 0.17162196286446 no 593 0.187281518291617 929 2898222 SGTC_1294 1000-1494 117 µM 0.887849343933444 0.17165115868161 no 594 0.187310898095536 890 712797 YDL207W GLE1 SGTC_986 1493-0483 84 µM 0.887680191660988 0.171696378276348 no 595 0.187356401978163 900 40079 SGTC_2449 5812982 45.77 µM 0.887588088041317 0.171721003600621 no 596 0.187381181771286 879 776185 SGTC_1679 SEC14.276 6.7 µM 0.88547595968301 0.172286332701015 no 597 0.187949989991952 982 1005053 YMR079W SEC14 SGTC_1141 3253-0389 52.6 µM 0.883792313248908 0.172737824521541 no 598 0.18840416830465 939 5402031 SGTC_1744 st037937 38.9 µM 0.88370253830265 0.172761920009028 no 599 0.188428404874707 914 1016152 SGTC_2317 5986382 200 µM 0.880595849838426 0.173597071074694 no 600 0.189268302838398 960 877883 SGTC_359 0081-0058 15.9 µM 0.879510279573888 0.173889502600057 no 601 0.189562330977712 845 3494159 SGTC_2537 larixol 68.93 µM 0.878803777455004 0.174079988718622 no 602 0.189753838889565 973 6708759 SGTC_1905 st060207 84.5 µM 0.878628857250268 0.174127170939395 no 603 0.189801271984019 923 1948547 SGTC_451 chloral hydrate 100 µM 0.877834477185258 0.17434154585343 no 604 0.19001677567742 987 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_3019 9081971 49.47 µM 0.877139453974808 0.174529245361559 no 605 0.19020544861294 998 16451803 SGTC_483 fpl-64176 144 µM 0.876537302503107 0.174691967444216 no 606 0.190369003350451 896 3423 SGTC_2770 toltrazuril 17.5 µM 0.871890332255104 0.175950977165498 no 607 0.191634104150831 983 68591 Kills coccidiodes. SGTC_1453 4237-0541 195 µM 0.870974455056276 0.17619979313317 no 608 0.191884050562935 966 739892 SGTC_228 caffeine 993.056 µM 0.870584695276997 0.176305746522097 no 609 0.191990478012662 909 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1958 st076513 41.9 µM 0.870181084330007 0.176415507731639 no 610 0.192100725716715 964 732122 YGL099W LSG1 SGTC_3280 9140961 49.47 µM 0.869776250149642 0.176525645013208 no 611 0.192211346454764 905 4901226 SGTC_1913 st060213 96.1 µM 0.868855902810058 0.176776192153343 no 612 0.192462975857137 996 688959 SGTC_1763 st044482 94.5 µM 0.867784392533902 0.177068173605123 no 613 0.192756187864185 957 88505 SGTC_278 4092-0821 23.9 µM 0.866756996338798 0.177348420130495 no 614 0.193037584486591 944 877900 SGTC_693 4161-2696 114 µM 0.866245083218082 0.177488160975876 no 615 0.193177887485611 918 805759 SGTC_622 1348-1566 26.3 µM 0.865761377243776 0.177620265745369 no 616 0.193310516769607 1001 7340407 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.864546305320824 0.177952387226783 no 617 0.193643927253979 980 688798 SGTC_3312 9133330 71.43 µM 0.862904913782186 0.178401658091519 no 618 0.194094874397487 1011 17617324 SGTC_1711 st032263 62.8 µM 0.861980125708172 0.17865509943488 no 619 0.194349227256029 925 3958979 SGTC_1449 4112-4002 201 µM 0.858151242696784 0.179706828776473 no 620 0.19540447749902 894 2059539 SGTC_2492 derrusnin 100 µM 0.856177400925025 0.180250526162948 no 621 0.195949830420302 896 1715307 Part of coumarin class of compounds. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.855323909992347 0.180485940760255 no 622 0.196185927195412 1049 6708561 SGTC_3323 9138564 53.9225 µM 0.855144347426682 0.180535493247184 no 623 0.196235620612005 1046 43912313 YNL103W MET4 SGTC_2180 6301957 200 µM 0.854253344749142 0.180781502540206 no 624 0.196482315877422 993 845462 SGTC_1657 st012939 43.4 µM 0.853683922045994 0.180938832369136 no 625 0.196640072470628 945 24207257 SGTC_2294 7971431 200 µM 0.853455787257908 0.181001889412302 no 626 0.196703297948317 880 5741572 SGTC_121 0557-0495 61.343 µM 0.852375610292228 0.18130064002051 no 627 0.197002826283911 1166 3104427 SGTC_1426 4048-4480 71.7 µM 0.850991833091582 0.181683809922327 no 628 0.197386944747912 983 14224343 SGTC_2179 6298986 200 µM 0.850432742026191 0.181838766657257 no 629 0.197542269505094 931 738374 SGTC_2428 5615643 7.78 µM 0.84845848576348 0.182386609262913 no 630 0.19809134147556 952 2253075 SGTC_1325 1431-0015 227 µM 0.84664094667608 0.182891874576745 no 631 0.198597641730548 916 1103340 SGTC_1352 1496-0991 99 µM 0.846285506572242 0.182990786890316 no 632 0.198696745573494 978 3000039 SGTC_1641 st009299 47.1 µM 0.843626518072752 0.183731791966253 no 633 0.199439070547211 944 4046054 SGTC_549 1661-1316 519 µM 0.843216316021403 0.183846273003304 no 634 0.199553737454583 1017 2857282 SGTC_2676 harmalol 100 µM 0.83819251438981 0.185251940150118 no 635 0.200961295254435 999 5459187 A monoamine oxidase inhibitor SGTC_2002 4023503 131 µM 0.836428803714871 0.185747007665641 no 636 0.20145685705261 1083 4736863 YCR052W RSC6 SGTC_2608 thymoquinone 42.66 µM 0.835808483674586 0.185921324272975 no 637 0.201631326529301 942 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1285 0929-0069 65.5 µM 0.835195145186244 0.186093778688551 no 638 0.201803921352977 981 1206237 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.834027782604296 0.186422283743866 no 639 0.202132664119909 940 15053 SGTC_1066 ketoconazole 628 nM 0.833025907609993 0.186704505529376 no 640 0.202415059026964 1035 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_709 3807-1509 243 µM 0.832976083651964 0.186718547520373 no 641 0.202429108882178 1003 1886677 YPL242C IQG1 SGTC_187 1488-2104 32.728 µM 0.832871798155772 0.186747940637516 no 642 0.202458518231113 1039 2852859 SGTC_1636 st007707 68.9 µM 0.830969455955904 0.187284622899095 no 643 0.20299544225299 1014 403051 SGTC_1847 st056231 15 µM 0.829266445099456 0.187765878569545 no 644 0.2034768268742 1075 5393180 SGTC_2990 9074105 71.4286 µM 0.829069695646783 0.187821527386486 no 645 0.20353248525848 985 6502001 SGTC_2966 9084041 48.03 µM 0.827617629656753 0.188232546131272 no 646 0.203943540441001 947 17741380 SGTC_2424 5537928 59.2 µM 0.826998049103428 0.188408092094131 no 647 0.204119083621153 1047 5382802 SGTC_1123 mangostin 811.285 nM 0.824569726339612 0.189097082519603 no 648 0.204807957325519 940 5281650 An antioxidant. SGTC_2722 naftopidil 47.16 µM 0.824565814510414 0.189098193677169 no 649 0.204809068158928 1017 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_195 4234-0266 16.654 µM 0.819532891381526 0.190531127952637 no 650 0.206241222022662 1031 2303354 SGTC_1516 st013856 110 µM 0.818773602154525 0.190747884096293 no 651 0.206457797303847 951 5281404 A mutagen and neurotoxin. SGTC_1736 st036774 51 µM 0.817816724700212 0.191021261652235 no 652 0.206730923323269 1070 1272247 SGTC_1719 st032227 49.2 µM 0.814467840775156 0.191979920281458 no 653 0.20768849407506 1047 3125804 SGTC_2034 5197015 53.07 µM 0.813604037901675 0.192227671220924 no 654 0.207935911969694 999 780676 SGTC_972 1319-0219 195 µM 0.813081371740652 0.192377674228791 no 655 0.20808570300577 978 23903702 SGTC_2446 5162541 200 µM 0.812751712068715 0.192472321979286 no 656 0.208180213004763 962 1549321 SGTC_189 3970-0742 2.116 µM 0.81236992046521 0.19258197276692 no 657 0.208289700335754 1033 2891807 SGTC_1118 chelidonine 707.474 nM 0.811911239139462 0.192713756809418 no 658 0.208421282435918 1095 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1013 4112-3890 241 µM 0.80882847746537 0.193600896119896 no 659 0.209306906717182 960 705171 SGTC_2517 totarol 10 µM 0.807893850727514 0.193870348825332 no 660 0.209575845776084 1008 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_719 2810-4230 27.3 µM 0.806553528692555 0.19425716210747 no 661 0.209961878285333 1027 721079 SGTC_1197 1601-0112 267 µM 0.806399201752459 0.194301730594922 no 662 0.210006353530336 1037 7350313 SGTC_2339 9000433 200 µM 0.805459435224509 0.19457326264619 no 663 0.210277302876962 962 2988954 SGTC_3012 9080433 71.4286 µM 0.804933001035084 0.194725469108649 no 664 0.210429171726333 1079 17688859 SGTC_3328 9140624 29.0385 µM 0.802500342789883 0.195429757098683 no 665 0.211131795096469 1064 4904392 SGTC_1891 st059073 26.2 µM 0.800909388398583 0.195891195973913 no 666 0.211592052287693 1111 688754 SGTC_3190 9110366 49.47 µM 0.800159931525334 0.196108796597822 no 667 0.211809070735461 958 17123768 SGTC_457 grayanotoxin iii 135 µM 0.799655507096266 0.196255335922818 no 668 0.211955209018584 1044 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1149 3909-7961 23.3 µM 0.799557307825373 0.196283871313454 no 669 0.211983665474429 1017 735261 SGTC_947 3447-0010 211 µM 0.799455041791027 0.196313591124608 no 670 0.212013302783304 1079 748350 SGTC_2553 4-methylesculetin 85.09 µM 0.799024094697306 0.196438859800484 no 671 0.212138220449576 1084 5319502 SGTC_2356 9061756 188.97 µM 0.798403370470859 0.196619378440651 no 672 0.212318223995663 1036 20104043 SGTC_1929 genistein trimethyl ether 50.5 µM 0.795900894627183 0.197348165624266 no 673 0.213044820616209 1078 136420 SGTC_1903 st060211 78.3 µM 0.795587471491399 0.197439557722833 no 674 0.21313592548178 1070 688960 SGTC_1442 4112-3290 3 µM 0.795493117364915 0.197467075768831 no 675 0.213163356496392 1084 704353 SGTC_2726 cimetidine 79.27 µM 0.793769341796448 0.197970216888645 no 676 0.213664861852589 1063 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_958 1222-0007 33 µM 0.793733468676372 0.197980695867401 no 677 0.213675305867627 1080 7312461 SGTC_2849 9019321 12.99 µM 0.793077217823536 0.198172453912627 no 678 0.213866417659437 994 16489627 SGTC_2021 4019055 173 µM 0.792279564885978 0.19840568089016 no 679 0.214098842179723 1090 44827708 YER133W GLC7 SGTC_1518 st038567 90.8 µM 0.791948489927535 0.198502533027574 no 680 0.214195355782438 1079 77966 SGTC_369 0957-0393 4.5 µM 0.791420202326605 0.198657136488094 no 681 0.21434941240975 1044 6997992 SGTC_3253 9135987 49.47 µM 0.790754118087522 0.198852169622484 no 682 0.214543744433733 997 4182430 SGTC_260 nsc-65238 3.989 µM 0.790521172982947 0.198920404463812 no 683 0.21461173101462 1019 3246252 SGTC_1617 st002906 78 µM 0.78950220594787 0.199219048579422 no 684 0.214909270487525 1048 5150859 SGTC_2135 5326629 150.42 µM 0.788903106168704 0.199394761826481 no 685 0.215084320060066 1008 5020077 SGTC_2904 7225135 42.03 µM 0.788660030492039 0.199466081420626 no 686 0.215155367378087 1101 4446116 SGTC_1005 4092-0690 4.4 µM 0.786923673671112 0.199975983494646 no 687 0.215663274111023 1017 1529343 SGTC_1155 4088-0394 48.2 µM 0.786775228201764 0.20001961262935 no 688 0.215706728554732 1035 2326248 SGTC_2721 ifenprodil 61.44 µM 0.784462147837245 0.200700181771311 no 689 0.216384492067802 1051 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1980 st071811 45.7 µM 0.783527780296226 0.200975491003245 no 690 0.21665862339136 1059 4974850 SGTC_27 0485-0001 32.618 µM 0.781670283949557 0.201523470441928 no 691 0.217204184923444 999 2054479 SGTC_1525 8-methoxypsoralen 92.5 µM 0.781019250350859 0.201715743342611 no 692 0.217395586341743 1120 4114 Related to psoralen; DNA damaging agent. SGTC_345 1362-0200 395 µM 0.780963239186031 0.201732290522052 no 693 0.217412057960875 1027 1419823 SGTC_3159 9100096 49.47 µM 0.780635359854139 0.201829171055117 no 694 0.217508494324075 1062 25236875 SGTC_3178 9107506 49.47 µM 0.777777863595325 0.202674671873863 no 695 0.21834999006109 1046 8897194 SGTC_2228 7354201 200 µM 0.777687948164974 0.20270131113799 no 696 0.218376499392403 1114 753451 SGTC_1182 1222-0449 220 µM 0.777365882168764 0.202796746869109 no 697 0.218471467762983 1030 658318 SGTC_2832 7992762 51.95 µM 0.775938558878793 0.20322001934241 no 698 0.218892632156676 965 2985177 SGTC_2413 inermin 26.06 µM 0.775331727122821 0.203400134826028 no 699 0.219071833160597 1084 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.774924040740569 0.203521194867465 no 700 0.219192272721001 1067 97141 SGTC_2601 securinine 100 µM 0.773497989006921 0.203944990387515 no 701 0.219613859216112 1051 442872 A GABA receptor antagonist. SGTC_218 alverine citrate 93.75 µM 0.77122013912386 0.204623013929489 no 702 0.220288229512298 1046 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3065 9113888 49.47 µM 0.770325960181396 0.204889540879276 no 703 0.220553280395791 1052 16648368 SGTC_1714 st033236 13.627 µM 0.76956593713633 0.205116242332136 no 704 0.220778708624116 1093 2916566 SGTC_1588 farnesol 29.9 µM 0.769456576227827 0.205148875023607 no 705 0.220811156701063 1059 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3267 9137951 49.47 µM 0.76686446092279 0.205923250734683 no 706 0.221581052825433 1085 16643986 SGTC_70 0141-0289 43.283 µM 0.764480435095833 0.206636989625908 no 707 0.222290495773267 1162 352408 SGTC_2202 7226349 200 µM 0.763641755860114 0.206888424601141 no 708 0.222540379343865 1074 844334 SGTC_1060 3448-7350 82 µM 0.763336916536018 0.206979859897149 no 709 0.222631245563731 1055 570178 SGTC_1841 st054148 70 µM 0.760980654261891 0.207687417401906 no 710 0.223334311178705 1023 675442 SGTC_1640 st009078 66.4 µM 0.759861491259137 0.208023988661329 no 711 0.223668691056978 1047 690618 SGTC_407 eburnamonine 100 µM 0.757977356295972 0.208591340359609 no 712 0.224232269283967 1035 3195 SGTC_2765 myclobutanil 7.74 µM 0.756874572781839 0.20892383389664 no 713 0.224562505144897 1108 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1745 st081495 74 µM 0.755205951926352 0.209427522763105 no 714 0.225062708990792 1102 13842402 YBL026W LSM2 SGTC_844 0330-0132 15.3 µM 0.754974071526335 0.209497574538778 no 715 0.225132269897513 1129 2828079 SGTC_11 0438-0307 1.3 µM 0.75472012930435 0.209574307070346 no 716 0.225208463016895 1097 4011476 SGTC_2875 9039966 71.43 µM 0.75456171091327 0.209622183985276 no 717 0.225256002452275 1136 6463691 SGTC_2132 5317594 122.667 µM 0.753548565817079 0.209928526917434 no 718 0.225560169363446 1055 794577 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.753208867044408 0.210031299917496 no 719 0.225662205903168 1060 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1550 gossypolone 36.6 µM 0.752103450008191 0.210365939079562 no 720 0.225994424690325 1135 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1071 trifluoperazine 6.31 µM 0.752060551203995 0.210378931996073 no 721 0.226007322941705 1117 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1955 wogonin 32.4 µM 0.751480179309901 0.210554757634983 no 722 0.226181862465682 1094 5281703 A flavanone. SGTC_3038 9091290 49.47 µM 0.75067865329051 0.210797724400733 no 723 0.226423036485107 1108 25236843 SGTC_3082 9117008 49.47 µM 0.750365460887203 0.210892707147748 no 724 0.22651731350747 1094 41448529 SGTC_2512 diallyl trisulfide 49.23 µM 0.749002437003991 0.211306367426726 no 725 0.226927868290881 1135 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1911 st060208 74.3 µM 0.747882579438995 0.211646585252322 no 726 0.227265493061207 1119 688783 SGTC_1644 st010134 20.9 µM 0.747813907017234 0.211667458675273 no 727 0.22728620625043 1096 3818134 SGTC_2534 helenine 20.12 µM 0.746310108425369 0.212124849912014 no 728 0.227740053271847 1099 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_741 4582-0002 126 µM 0.745394660454636 0.212403572789679 no 729 0.228016585422819 1092 2912688 SGTC_2279 7948423 32.93 µM 0.744996399444252 0.21252489653395 no 730 0.228136948265574 1102 1247112 SGTC_690 glyoxal 20.3 µM 0.743354242532794 0.213025580330566 no 731 0.228633619749349 1049 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2206 7254556 146.969 µM 0.742121890385894 0.213401768710198 no 732 0.229006743993163 1124 4398905 SGTC_2621 lithochol-11-enic acid 100 µM 0.742040180920476 0.213426725060504 no 733 0.229031495569711 1127 6708711 SGTC_538 2922-0838 53.3 µM 0.74104284734948 0.213731475633769 no 734 0.229333730559979 1171 777039 SGTC_1188 1403-0014 4.57 µM 0.740162096931979 0.214000813062569 no 735 0.229600821642317 1156 9614867 SGTC_997 3996-0078 137 µM 0.738741612843386 0.214435619483373 no 736 0.230031956055839 1177 735687 SGTC_2611 pyromycin 23.93 µM 0.736170490934214 0.215223938159613 no 737 0.23081347410887 1129 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1498 4478-3555 97.6 µM 0.736121313271704 0.215239032649084 no 738 0.23082843658654 1111 3437919 SGTC_812 4251-0442 148 µM 0.735915879203721 0.215302094798499 no 739 0.230890946485301 1130 5723007 SGTC_1209 2323-2347 50.3 µM 0.735201879813672 0.21552135474769 no 740 0.231108277180059 1141 5412760 SGTC_943 3253-1379 105 µM 0.734434443014142 0.215757168974787 no 741 0.231342000663175 1102 668464 SGTC_554 4483-2211 187 µM 0.733867300262899 0.215931533889045 no 742 0.231514809111743 1095 747107 SGTC_2899 9053889 58.44 µM 0.732513551112278 0.216348066491259 no 743 0.231927587352821 1115 6470052 SGTC_659 k018-0002 107 µM 0.731753213144838 0.216582217312929 no 744 0.232159605326041 1141 6797879 YHR007C ERG11 SGTC_2264 7948757 110.76 µM 0.731521833816848 0.21665350110515 no 745 0.232230236613333 1146 2971411 SGTC_2086 5274770 176.623 µM 0.731177431129828 0.216759630481855 no 746 0.232335391765226 1125 689278 SGTC_1318 1280-3875 124 µM 0.731167138135387 0.216762802781156 no 747 0.232338534893357 1121 373245 SGTC_1264 0783-0040 158 µM 0.730197095209701 0.217061890328705 no 748 0.232634858936094 1076 2855798 SGTC_1937 st074714 47.2 µM 0.729357737585129 0.217320876787546 no 749 0.232891431309146 1133 17250970 SGTC_1654 st012436 41.8 µM 0.728326673651504 0.217639258941403 no 750 0.233206818940828 1110 4323132 SGTC_3227 9130768 49.47 µM 0.728217617324102 0.217672950169151 no 751 0.233240191561436 1144 17720899 SGTC_808 0711-0032 135 µM 0.728105586760392 0.217707563373496 no 752 0.233274477095971 1143 4252555 SGTC_2675 theaflavin digallate 100 µM 0.728069595523249 0.217718683977591 no 753 0.233285492351659 1124 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_590 k048-0076 22.4 µM 0.725008283765411 0.218665769534105 no 754 0.234223474248562 1131 6832814 SGTC_1884 5633444 25 µM 0.723762836519699 0.219051754227701 no 755 0.234605674310591 1138 5724239 SGTC_2251 lansoprazole 556 µM 0.720600581492541 0.220033547806322 no 756 0.235577647990002 1004 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2564 betulinic acid 100 µM 0.719709133978349 0.220310773308361 no 757 0.235852050626291 1197 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_964 1287-0107 19.4 µM 0.719223385187215 0.220461917432834 no 758 0.236001646459506 1155 51516812 YPR165W RHO1 SGTC_2372 9071633 200 µM 0.718104294286373 0.220810356442301 no 759 0.236346491281078 1202 21321366 SGTC_99 0109-0120 622.8 µM 0.718011100601852 0.220839387350286 no 760 0.236375221169662 1172 759414 SGTC_1621 st003705 32.4 µM 0.717172184346875 0.221100817805624 no 761 0.236633930060534 1204 24207032 SGTC_3141 9094609 49.47 µM 0.716415240421297 0.22133685522631 no 762 0.236867493567434 1121 25236309 YDL196W YDL196W SGTC_969 1313-0238 134 µM 0.715509856442556 0.22161936980049 no 763 0.237147026302097 1190 5212874 SGTC_1524 corynanthine 62.1 µM 0.715206937159313 0.221713938239315 no 764 0.237240591549403 1164 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2334 9017922 200 µM 0.713819853128507 0.222147266703075 no 765 0.237669290846802 1174 3163164 SGTC_2075 5212009 200 µM 0.71287468525606 0.222442816166063 no 766 0.237961652577633 1094 780898 SGTC_1434 4073-0095 163 µM 0.712689326514279 0.222500803246779 no 767 0.238019011331097 1191 24133745 SGTC_174 3553-0389 74.3 µM 0.711125024913962 0.222990517943321 no 768 0.23850338189646 1153 738071 SGTC_2984 9022109 38.96 µM 0.710252187957931 0.223264031788964 no 769 0.238773881620735 1186 6459207 SGTC_843 0310-0051 143 µM 0.70951402348898 0.223495493361456 no 770 0.239002776098385 1202 2065037 SGTC_2719 novobiocin 32.65 µM 0.709459254937616 0.223512672228215 no 771 0.23901976383945 1163 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1423 4048-0112 5.59 µM 0.708776368484483 0.223726931482374 no 772 0.239231632386274 1188 X1423 SGTC_1022 4477-0945 21.3 µM 0.708245309534567 0.223893634731342 no 773 0.239396466679916 1165 4648966 SGTC_2566 crystal violet carbinol 226 nM 0.705759234920672 0.224674969594834 no 774 0.240168938490369 1138 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.705318188303974 0.224813745077188 no 775 0.240306122011896 1180 616764 SGTC_1924 st058459 75.1 µM 0.704140948521559 0.225184401909628 no 776 0.240672500663313 1159 688683 SGTC_781 4335-2806 94.4 µM 0.703845780863343 0.225277390420496 no 777 0.240764409912105 1253 845254 SGTC_2876 9059903 25.97 µM 0.701788828136383 0.22592600858769 no 778 0.241405433467206 1175 6916095 SGTC_134 0269-0018 6.916 µM 0.701751751194748 0.225937709726391 no 779 0.241416996532063 1107 4378915 SGTC_776 4476-4378 112 µM 0.701241185968172 0.22609887421611 no 780 0.241576255437339 1141 2892008 SGTC_543 3844-1095 191 µM 0.700602297473058 0.226300636585177 no 781 0.241775622119728 1185 4230703 SGTC_1269 0831-0796 3.05 µM 0.699886138017518 0.226526922143034 no 782 0.241999207491806 1177 927758 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.69906811444866 0.226785550019643 no 783 0.242254732038058 1201 16623 A steroid. SGTC_2300 7976697 71.57 µM 0.69839248923946 0.226999282523503 no 784 0.242465886082962 1113 2236109 SGTC_850 0388-0143 75.9 µM 0.697649498869581 0.227234456927778 no 785 0.242698208906316 1155 67273 SGTC_3036 9090181 49.47 µM 0.696725330109086 0.227527170193974 no 786 0.242987351797545 1200 25236586 SGTC_1031 k035-0009 16 µM 0.695959577045173 0.227769869014337 no 787 0.243227072569251 1221 5180959 SGTC_3342 9147791 14.508 µM 0.695815908559387 0.22781541972712 no 788 0.243272062560777 1162 1838168 SGTC_3087 9117406 49.47 µM 0.6958102668089 0.227817208573035 no 789 0.243273829374782 1191 42546093 SGTC_2655 perillic acid 100 µM 0.694433986726995 0.228253825714543 no 790 0.243705042986484 1183 5702197 An apoptosis inducer. SGTC_2001 4023502 57.655 µM 0.694430054825556 0.228255073761697 no 791 0.243706275513672 1183 108941 YCR052W RSC6 SGTC_3042 9091578 49.47 µM 0.693660613033568 0.22849938046164 no 792 0.243947536022147 1165 25236497 SGTC_65 0798-0905 34.986 µM 0.693626521174263 0.228510208420106 no 793 0.243958228595201 1285 3602145 SGTC_2399 5884133 200 µM 0.692042690853443 0.2290135684138 no 794 0.244455259875699 1222 722445 SGTC_3110 9122132 49.47 µM 0.691853850514432 0.229073625584873 no 795 0.244514557376035 1265 918317 SGTC_1754 st042065 16.137 µM 0.691766243042427 0.229101490518012 no 796 0.244542069511237 1167 1126236 YIL048W NEO1 SGTC_2833 9001315 45.46 µM 0.690672455791856 0.229449546749171 no 797 0.244885701347563 1191 2989378 SGTC_1319 1306-0155 43.7 µM 0.690449518366 0.229520524452002 no 798 0.244955772792101 1235 3122360 SGTC_975 1335-0046 28.5 µM 0.690354318748574 0.229550837378181 no 799 0.244985698262937 1195 16486740 SGTC_455 paf C-16 10 µM 0.689351160506882 0.229870393692784 no 800 0.245301155012605 1182 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2225 6654152 15.4 µM 0.689102019203951 0.229949796307285 no 801 0.24537953471819 1170 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_804 1595-0054 20.9 µM 0.689025796458928 0.229974091954568 no 802 0.245403517036971 1192 761523 Stimulates phospholipase C. SGTC_472 calcifediol 10 µM 0.688789792816317 0.230049326133627 no 803 0.245477779954093 1191 5283731 A vitamin D metabolite. SGTC_928 2764-0428 58.7 µM 0.688706974990459 0.230075730393375 no 804 0.245503842978613 1200 662578 SGTC_3243 9134147 49.47 µM 0.688298807774008 0.230205888418119 no 805 0.245632316173453 1260 24282180 SGTC_2854 9024559 71.43 µM 0.687662170983373 0.230408983946515 no 806 0.245832773659899 1191 3163529 SGTC_2065 5221596 34.26 µM 0.68670897964429 0.230713251729848 no 807 0.246133068591898 1192 788581 SGTC_2411 st077133 39.94 µM 0.686240371881694 0.230862918064716 no 808 0.24628077163804 1279 1403142 YNL221C POP1 SGTC_823 0417-1665 178 µM 0.685924525124563 0.23096382538994 no 809 0.246380351907951 1233 3429856 SGTC_2136 5328288 199.296 µM 0.682507539941815 0.232057063079499 no 810 0.247459038362648 1177 262395 SGTC_3268 9137683 49.47 µM 0.681577700852906 0.232355055686566 no 811 0.247753009599291 1213 1953228 SGTC_629 3448-6466 76.7 µM 0.680757514463165 0.232618083657908 no 812 0.248012468527142 1223 573744 SGTC_1626 st003712 1.76 µM 0.680334667433532 0.23275375234599 no 813 0.24814628917484 1195 24207035 SGTC_111 0083-0039 52.457 µM 0.679229814286834 0.233108447283937 no 814 0.248496129626498 1143 759313 SGTC_413 propylparaben 100 µM 0.678334974918982 0.233395940569508 no 815 0.24877966386996 1198 7175 A pharmaceutical preservative. SGTC_328 k915-0120 63.5 µM 0.677564155637944 0.233643746403745 no 816 0.24902403976601 1196 6624543 SGTC_2981 9013952 38.96 µM 0.674127938580242 0.234750206886276 no 817 0.25011498928305 1150 2996344 SGTC_2185 6113692 200 µM 0.673668657286577 0.234898314433193 no 818 0.250260996326974 1223 874150 SGTC_1358 1509-0022 2.48 µM 0.673640941546497 0.234907253767339 no 819 0.250269808698224 1247 3258434 SGTC_1673 st016611 27.3 µM 0.673267358928534 0.235027766092082 no 820 0.250388607390235 1241 5226799 SGTC_2242 6630449 61.2675 µM 0.672785222426365 0.235183346794757 no 821 0.250541970218567 1220 691249 YDR170C SEC7 SGTC_3257 9139206 32.98 µM 0.672573743703826 0.235251606836757 no 822 0.250609255197297 1193 4910041 SGTC_2860 9025725 38.96 µM 0.672408214330557 0.235305043209128 no 823 0.250661927411343 1196 40546248 SGTC_523 1934-0222 13.7 µM 0.671679812815635 0.235540266179739 no 824 0.250893777803956 1243 1361595 SGTC_304 1310-0298 97 µM 0.671287336304174 0.235667062528053 no 825 0.251018750222317 1179 1550234 SGTC_1482 3346-2049 8.48 µM 0.669683493414656 0.236185602854857 no 826 0.251529788194234 1229 3826804 SGTC_224 benfluorex 43.875 µM 0.667752071181365 0.236810886417723 no 827 0.252145932724856 1233 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1779 st039427 55 µM 0.667244412166243 0.236975388188306 no 828 0.252308013447921 1279 1124498 SGTC_1292 0kpi-0043 232 µM 0.666055132045212 0.237361008194865 no 829 0.2526879308771 1230 3333905 SGTC_1514 1189-1591 158 µM 0.664802217648847 0.237767633825635 no 830 0.25308850202696 1271 767698 YMR146C TIF34 SGTC_1596 piperlongumine 63 µM 0.663852748580997 0.238076032457506 no 831 0.253392280550777 1260 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2709 st078560 56 µM 0.663802699964375 0.238092294912595 no 832 0.253408298704848 1262 17250903 SGTC_20 0481-0013 4.944 µM 0.663726535042149 0.238117044589512 no 833 0.253432676452906 1229 182045 SGTC_2368 9071271 200 µM 0.66271536411432 0.238445756631185 no 834 0.253756433927975 1229 27209959 SGTC_3264 9137442 49.47 µM 0.662681799078825 0.238456672231598 no 835 0.253767184529154 1290 17015726 SGTC_1832 st054113 55 µM 0.662330554973348 0.238570915849942 no 836 0.253879699432331 1235 1251267 SGTC_1627 st003713 25.6 µM 0.661838979576968 0.238730853099687 no 837 0.254037210963602 1285 16195070 YER133W GLC7 SGTC_1391 3442-0225 151 µM 0.65989712258774 0.239363222085723 no 838 0.254659925429785 1223 5227075 SGTC_513 4245-1575 41.7 µM 0.659718770091921 0.239421348715341 no 839 0.254717159543182 1232 719745 SGTC_1622 st003707 19.4 µM 0.659489720539162 0.239496009262265 no 840 0.254790672447009 1289 10140899 SGTC_634 1611-4317 11.2 µM 0.659230781140247 0.239580427951776 no 841 0.254873791798803 1257 2843522 SGTC_3286 9117135 37.221 µM 0.657235986368052 0.240231309546668 no 842 0.255514594897902 1213 3438150 SGTC_3175 9106517 49.47 µM 0.656945855343108 0.240326056603294 no 843 0.255607865955965 1245 41468073 SGTC_2845 9003024 42.97 µM 0.656939589605408 0.240328103007519 no 844 0.255609880455767 1311 2990173 SGTC_2393 9031399 185.94 µM 0.655075996841886 0.240937177772663 no 845 0.256209412706365 1294 1526623 YDL150W RPC53 SGTC_2432 5630864 12.22 µM 0.654845087534807 0.241012703874606 no 846 0.256283749039125 1240 5714970 SGTC_213 1246-0773 967 nM 0.65456860470328 0.241103153155679 no 847 0.256372771585233 1243 6251622 SGTC_3297 9117502 71.43 µM 0.653692373338192 0.241389927547192 no 848 0.256655008903627 1247 7453720 SGTC_1241 0364-0022 50.8 µM 0.652947784230192 0.241633763414119 no 849 0.256894970866854 1273 4563895 SGTC_1072 oxiconazole 14.9 nM 0.650994307940708 0.242274117257068 no 850 0.257525080629026 1287 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_64 000l-0018 272.079 µM 0.65025834833637 0.242515604748871 no 851 0.257762678440424 1227 6811119 SGTC_2057 5236571 38.335 µM 0.648189249539367 0.243195227827606 no 852 0.258431277134486 1270 54684039 YBR257W POP4 SGTC_1800 st050079 29.0735 µM 0.646433036789294 0.243772886224225 no 853 0.25899947542285 1238 3645560 SGTC_1061 3448-9325 110 µM 0.643697769367736 0.24467405110324 no 854 0.25988571833945 1241 723482 SGTC_201 4262-0159 12.803 µM 0.643249059810846 0.24482205464165 no 855 0.260031252124027 1241 1341029 SGTC_3151 9099821 49.47 µM 0.643142634068744 0.244857165456659 no 856 0.260065776254117 1238 17174189 SGTC_2723 salbutamol 83.58 µM 0.641806875144189 0.245298074781436 no 857 0.260499292560043 1271 9884233 β2-adrenoceptor agonist SGTC_438 sphingosine 6.67 µM 0.639839635539161 0.245948200546897 no 858 0.261138430802504 1157 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1238 0333-0287 48.8 µM 0.639531166567102 0.246050225975288 no 859 0.261238722610818 1277 7226 SGTC_3037 9091026 49.47 µM 0.63850546005706 0.246389639328618 no 860 0.261572350467654 1299 25236398 YIL048W NEO1 SGTC_1526 st051518 75 µM 0.636984814081467 0.246893292981664 no 861 0.26206736765665 1290 673993 SGTC_80 0159-0065 512.242 µM 0.636928159607486 0.246912068169829 no 862 0.262085819709757 1241 1548079 SGTC_845 0330-0138 4.51 µM 0.631944005761273 0.248566794023049 no 863 0.263711733395424 1289 9039800 SGTC_876 0720-0963 56.8 µM 0.631943306926339 0.248567026447907 no 864 0.26371196172718 1329 765861 SGTC_3318 9139014 38.6185 µM 0.6289628362762 0.249559350788423 no 865 0.264686693384008 1287 16643984 SGTC_2905 7799065 20.05 µM 0.628492883215622 0.249716009848641 no 866 0.264840553664187 1259 1296806 SGTC_771 0250-0039 27.3 µM 0.628280099760635 0.249786958479661 no 867 0.264910232852217 1309 3005115 SGTC_2750 bromebric acid 70.15 µM 0.626503033519817 0.250379905407956 no 868 0.265492523898518 1347 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2045 5106652 78.05 µM 0.626092257656859 0.250517073513801 no 869 0.265627215106776 1277 673349 SGTC_2470 5664817 21.68 µM 0.623146987465948 0.251501736348007 no 870 0.266593967346696 1331 2859561 SGTC_2301 7769476 200 µM 0.622453318826227 0.251733940859709 no 871 0.266821914956559 1333 977820 SGTC_2794 7785382 27.27 µM 0.622451037020241 0.251734704877527 no 872 0.266822664947117 1287 2205081 SGTC_151 3013-0144 2.285 µM 0.62161541312188 0.252014579403091 no 873 0.267097391819262 1340 906558 YHR107C CDC12 SGTC_36 0335-0881 14.2 µM 0.621193803498232 0.252155850907423 no 874 0.267236057996506 1260 23828853 SGTC_2653 dihydrofissinolide 100 µM 0.62048488057352 0.252393488496662 no 875 0.267469302557332 1326 6857746 SGTC_1045 1348-1485 165 µM 0.61940529848345 0.252755601131761 no 876 0.267824695753532 1317 6810614 SGTC_1492 4158-0558 28.5 µM 0.618922751245841 0.252917545191191 no 877 0.267983624860353 1348 3967268 SGTC_673 1082-0474 110 µM 0.617289312825927 0.253466136243632 no 878 0.268521957359148 1333 3098046 SGTC_2642 cholecalciferol 100 µM 0.616515710372791 0.253726169013332 no 879 0.268777103175903 1318 9821465 A vitamin D precursor, similar to steriods. SGTC_1451 4152-0210 104 µM 0.615399640256783 0.254101562905087 no 880 0.269145414464905 1359 659563 SGTC_1117 retinoic acid 1.10837 µM 0.614252811670192 0.254487605779469 no 881 0.269524139882096 1356 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_515 4092-1064 102 µM 0.612555057961989 0.255059663531644 no 882 0.2700852911486 1385 717353 SGTC_1574 spiramycin 23.7 µM 0.612168701180576 0.25518994026176 no 883 0.270213073594166 1284 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1176 0848-0131 83.3 µM 0.609831139265343 0.25597889083805 no 884 0.270986835817558 1372 6769040 SGTC_3229 9132204 49.47 µM 0.608214915715464 0.256525125668869 no 885 0.271522471610403 1338 17682924 SGTC_2286 7945697 125 µM 0.607684070893087 0.256704667587506 no 886 0.271698514896432 1283 1245733 SGTC_1889 st059080 5.18 µM 0.606504369926142 0.257103899248721 no 887 0.27208994070874 1338 176925 Isolated from Daphnopsis sellowiana. SGTC_2273 7815444 169.05 µM 0.605121126304779 0.257572424274177 no 888 0.272549258967443 1354 2824616 SGTC_3313 9133968 57.047 µM 0.603353732038173 0.258171711379826 no 889 0.273136697446398 1312 1494643 SGTC_1119 parthenolide 318.541 nM 0.603238757745706 0.25821072182899 no 890 0.27317493380453 1445 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1748 st037455 53.6035 µM 0.602332820591004 0.258518210579752 no 891 0.273476309013285 1347 580690 SGTC_1656 st012921 11 µM 0.602251857450746 0.258545699920925 no 892 0.273503250771376 1324 6732821 SGTC_514 4466-0038 2.65 nM 0.600877660851479 0.25901251043085 no 893 0.273960736589113 1297 5722064 SGTC_149 3970-0822 46.1 µM 0.597531937138639 0.260150862674898 no 894 0.275076145416521 1413 3114250 YBL034C STU1 SGTC_1993 st073995 70.8 µM 0.597505895762725 0.260159733121106 no 895 0.275084835944491 1361 3098394 SGTC_3057 9095946 49.47 µM 0.596035801038423 0.260660742619919 no 896 0.275575655129858 1369 24540043 SGTC_2718 lomofungin 53.02 µM 0.592995432980782 0.261698475808739 no 897 0.276592104340618 1403 5351222 A RNA synthesis inhibitor. SGTC_598 3937-0236 20.2 µM 0.591776016264198 0.262115279838731 no 898 0.277000292778548 1376 1379313 SGTC_663 1486-0733 13.9 µM 0.5917261617078 0.262132327664425 no 899 0.277016987401446 1341 722445 YPR165W RHO1 SGTC_2551 apiole 73.87 µM 0.591012758921262 0.262376338832017 no 900 0.277255936060367 1285 10659 A possible DNA adduct former. SGTC_280 3448-3607 3.04 µM 0.590961537286259 0.26239386307398 no 901 0.277273096222864 1335 626179 SGTC_2528 xanthyletin 44.79 µM 0.590350993355314 0.26260279203269 no 902 0.277477679332032 1389 65188 An natural product with antifungal activity of unknown mechanism. SGTC_96 0929-0093 37.281 µM 0.589504459456411 0.26289261786191 no 903 0.277761460763078 1319 6991579 SGTC_3170 9103054 49.47 µM 0.588797125934551 0.263134911343137 no 904 0.277998687035578 1297 16432970 SGTC_2769 toremifene 3.73 µM 0.587574174901414 0.263554095965277 no 905 0.278409074743901 1375 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1713 st033146 12.748 µM 0.586532728646677 0.263911335591477 no 906 0.278758787183353 1422 674619 SGTC_186 3455-3465 67.277 µM 0.586342848746586 0.263976495287296 no 907 0.27882257094213 1308 755278 SGTC_3014 9081533 49.47 µM 0.583309273657985 0.265018615748751 no 908 0.279842560382624 1403 21367265 SGTC_1089 terbinafine 2.25 µM 0.583060283569427 0.265104243746845 no 909 0.279926359486412 1391 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1362 1611-0397 101 µM 0.582710810455119 0.265224451680411 no 910 0.280043997275018 1363 27816 SGTC_2831 7999036 19.48 µM 0.582279212676895 0.265372946141892 no 911 0.280189312497072 1485 2988270 SGTC_26 0302-0163 425.158 µM 0.582033444627652 0.265457523338299 no 912 0.280272076785694 1369 3100915 SGTC_1321 1326-2144 215 µM 0.579210858205969 0.266429851446455 no 913 0.281223452559352 1380 3513030 SGTC_2835 9006588 71.43 µM 0.578848251971479 0.266554892971176 no 914 0.281345784887471 1370 2345538 SGTC_1968 st069590 43.6 µM 0.576807852248977 0.267259059511094 no 915 0.282034632264266 1346 6384066 SGTC_1716 st033144 30.6155 µM 0.576656492984164 0.26731133279422 no 916 0.28208576412061 1408 674617 SGTC_2589 lobaric acid 100 µM 0.574941728853395 0.267903902047132 no 917 0.282665353504432 1356 73157 A novel microtubule depolymerizer. SGTC_200 k038-0079 37.545 µM 0.574726639154756 0.267978277040009 no 918 0.28273809408639 1387 3436683 SGTC_656 4090-1979 187 µM 0.5734933454952 0.268404933258674 no 919 0.283155351747856 1410 22330961 SGTC_2838 9002687 71.43 µM 0.572786540497886 0.26864960535024 no 920 0.283394616710089 1360 6457060 SGTC_77 0828-0286 12.516 µM 0.572132119355304 0.268876243795363 no 921 0.28361623527005 1336 745345 SGTC_1384 3089-0840 101 µM 0.572068585644159 0.26889825183553 no 922 0.283637755269488 1417 1069836 SGTC_255 tunicamycin 200.472 nM 0.570968537676452 0.269279451156799 no 923 0.284010485071041 1383 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1642 st009582 77.7 µM 0.570487009379383 0.269446400268278 no 924 0.284173715252792 1433 6739311 SGTC_2309 7664088 163.95 µM 0.57039278968828 0.269479072939487 no 925 0.284205659426954 1403 704922 SGTC_2111 5486399 200 µM 0.567330002830892 0.270542239311417 no 926 0.285244998284958 1372 689674 SGTC_1887 st057648 70.8 µM 0.564194374649298 0.271632857116328 no 927 0.28631092789538 1453 688672 SGTC_1900 st060200 72.8 µM 0.563361061807761 0.271923063364791 no 928 0.286594523110052 1398 688945 SGTC_3345 9148410 3.559 µM 0.563180543943821 0.271985950123142 no 929 0.286655974976516 1397 4903596 SGTC_2245 6637752 200 µM 0.561714696706619 0.272496872976537 no 930 0.28715520972151 1430 681890 SGTC_894 0960-0238 55.9 µM 0.56162792989379 0.272527130588536 no 931 0.287184773453585 1384 6741907 YDL195W SEC31 SGTC_2231 micatex 6.853 µM 0.560469930838462 0.272931111498201 no 932 0.287579472007826 1414 20737 An antifungal of unknown mechanism. SGTC_426 0988-0037 14.6 µM 0.560272877866737 0.272999885182445 no 933 0.287646662113177 1407 5383008 SGTC_2818 7996756 12.99 µM 0.559103119820728 0.273408320576849 no 934 0.28804567284277 1370 2241621 SGTC_2464 5717415 7.67 µM 0.558435266678064 0.273641645310834 no 935 0.288273598212906 1326 5285744 SGTC_733 4069-0007 56.1 µM 0.557817172627644 0.2738576736874 no 936 0.288484617523423 1431 5717425 YNL287W SEC21 SGTC_830 4076-0286 57.8 µM 0.554896632421779 0.274879562876751 no 937 0.289482682718665 1446 6866659 SGTC_564 3555-0129 330 µM 0.554582116479445 0.274989723147163 no 938 0.289590262028672 1349 563260 SGTC_3108 9121785 49.47 µM 0.553694317743845 0.275300794950693 no 939 0.289894032361088 1436 17140271 SGTC_1935 st074532 41.6 µM 0.553693276374155 0.275301159933203 no 940 0.289894388765186 1488 2829742 SGTC_481 bay k-8644 50 µM 0.553224667720398 0.275465423523382 no 941 0.290054788819932 1353 2303 A calcium channel antagonist. SGTC_1365 1672-3266 55.4 µM 0.549434136601489 0.276795905744502 no 942 0.291353776354472 1433 6415873 SGTC_1969 st069479 40.1 µM 0.547592221178963 0.277443555365311 no 943 0.291985965932189 1480 3895485 SGTC_991 3996-0057 64.7 µM 0.547473684275612 0.277485260366372 no 944 0.29202667250738 1424 715343 SGTC_2431 5490079 200 µM 0.547389106957737 0.277515019192919 no 945 0.292055718688639 1407 5722345 SGTC_1946 st076057 65.1 µM 0.546837689649248 0.277709075535299 no 946 0.292245123543031 1329 953009 SGTC_1906 st060206 94.7 µM 0.546327283398826 0.277888758194787 no 947 0.29242049252629 1404 5133468 SGTC_2898 9056270 58.44 µM 0.545433031790265 0.278203705951115 no 948 0.292727863698438 1379 19154699 SGTC_2437 5741531 144.16 µM 0.544225324269714 0.278629326271414 no 949 0.293143213573663 1526 2262990 SGTC_2622 2-methoxyxanthone 59.94 µM 0.543246368125579 0.278974562548596 no 950 0.293480092618451 1519 71034 A hepatoprotective. SGTC_2182 6325192 200 µM 0.542693540633483 0.279169613223347 no 951 0.29367041117389 1370 736248 SGTC_2448 5185112 27.17 µM 0.542442882509616 0.279258073203235 no 952 0.293756722539411 1391 5718189 SGTC_1443 4112-3303 14 µM 0.541258861654317 0.279676111095431 no 953 0.294164585677108 1397 704433 SGTC_2236 dapsone 200 µM 0.538710200088344 0.280576986781329 no 954 0.295043417237164 1414 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_752 1896-0090 130 µM 0.538383410332696 0.280692598678154 no 955 0.295156188568051 1432 772567 SGTC_848 0368-0089 85.6 µM 0.537430292431937 0.281029924912874 no 956 0.295485211733801 1392 762535 SGTC_2591 skatole 100 µM 0.536855282707797 0.281233526283503 no 957 0.295683790776741 1433 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1907 st060210 83.7 µM 0.536781075128243 0.281259807140085 no 958 0.295709422759117 1506 688793 SGTC_2240 6690706 185.951 µM 0.536135026247134 0.281488657543969 no 959 0.295932617128321 1351 805876 SGTC_2665 lovastatin 100 µM 0.534528530147777 0.282058117045386 no 960 0.29648795798656 1410 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.534254575563419 0.282155281889429 no 961 0.296582707493563 1399 75037 A free radical scavenger. SGTC_2253 7938677 135.83 µM 0.53342040651295 0.282451239990271 no 962 0.296871297290732 1542 2301972 SGTC_1272 0839-0021 27 µM 0.533219208747765 0.282522646073382 no 963 0.29694092306284 1428 5027250 SGTC_8 0354-0001 70 µM 0.532310798461989 0.282845153398629 no 964 0.297255377219826 1470 4993152 SGTC_1450 4112-4260 37.6 µM 0.532121712436425 0.282912305675669 no 965 0.297320850129718 1457 1633175 SGTC_2055 5235184 200 µM 0.531445410759734 0.283152551043461 no 966 0.297555080195331 1447 2836034 SGTC_814 3342-0569 96 µM 0.531308204614293 0.283201303276298 no 967 0.297602610396187 1464 4346283 SGTC_2440 5628896 157.78 µM 0.529894148326995 0.283703981715179 no 968 0.298092661782438 1479 5522048 SGTC_3233 9132340 49.47 µM 0.528687099193471 0.284133409612396 no 969 0.298511263983567 1398 17682950 SGTC_2299 7976368 114.88 µM 0.528668329744227 0.28414008961134 no 970 0.298517775301685 1540 2979718 SGTC_746 1095-0025 46.6 µM 0.52859833391954 0.284165001608461 no 971 0.298542058154598 1499 6749286 SGTC_1512 0259-0544 12.2 µM 0.527721530477271 0.284477150457684 no 972 0.298846313660652 1479 18476 SGTC_2352 9027995 87.8 µM 0.527513548569277 0.284551217663187 no 973 0.298918505169039 1464 2997347 SGTC_828 2074-0507 139 µM 0.527398039993812 0.284592356936835 no 974 0.298958602165592 1520 X828 SGTC_2913 7966556 36.57 µM 0.526747197026962 0.284824212770143 no 975 0.299184577776296 1488 2976516 SGTC_3274 9138298 49.47 µM 0.526717151110502 0.284834918481988 no 976 0.299195011725491 1408 17015756 SGTC_1829 berberine 14.4 µM 0.525242674745575 0.285360527425617 no 977 0.299707251162321 1528 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1078 idebenone 36.1 µM 0.524510715445291 0.285621621595657 no 978 0.299961684429417 1444 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2900 5328528 85.29 µM 0.523989650034221 0.28580755792131 no 979 0.300142869303633 1405 795359 SGTC_2332 7982454 138.89 µM 0.523324636919322 0.286044943945299 no 980 0.300374179537575 1443 2981748 SGTC_318 1488-0629 67.2 µM 0.523318737754672 0.286047050156395 no 981 0.300376231793068 1420 3662576 SGTC_2690 usnic acid 100 µM 0.523022374910923 0.286152871690911 no 982 0.300479341369925 1586 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_641 4092-0595 30 µM 0.522670089869146 0.286278685409177 no 983 0.300601928004048 1481 786260 SGTC_1000 4048-0884 8.67 µM 0.522401299873075 0.286374697691399 no 984 0.300695475574272 1480 13040088 SGTC_713 1488-1073 324 µM 0.522085643316254 0.286487470305988 no 985 0.300805350987732 1444 3312542 SGTC_2244 6635614 200 µM 0.521921783252424 0.286546019858027 no 986 0.300862395411115 1451 836499 SGTC_1782 st039423 80.636 µM 0.521591746829183 0.286663963835121 no 987 0.300977305435375 1406 2068169 SGTC_112 phenothiazine 287.218 µM 0.521573671930426 0.286670423864131 no 988 0.300983599212404 1493 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2851 9015922 71.43 µM 0.521527296820257 0.286686998798709 no 989 0.300999747546775 1506 2996893 SGTC_1785 bathophenanthroline 24 µM 0.520124021198318 0.287188758511963 no 990 0.301488568481676 1409 72812 An iron chelator. SGTC_2552 juarezic acid 87.02 µM 0.51878754941471 0.287667017765673 no 991 0.301954450619594 1465 1549512 SGTC_1803 st050068 52.4 µM 0.517942409976723 0.287969646837592 no 992 0.30224922550009 1518 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.517896926026093 0.2879859380749 no 993 0.302265093438256 1421 2346 DNA damaging agent; causes G2/M arrest. SGTC_2656 pseudo-anisatin 100 µM 0.51644036015214 0.288507874215812 no 994 0.302773441565277 1464 6708809 A neurotoxin. SGTC_302 1094-0063 18.9 µM 0.516165179406765 0.288606530696574 no 995 0.302869523885574 1403 5440289 SGTC_754 3474-0146 171 µM 0.515843686594906 0.288721810882407 no 996 0.302981793849313 1371 24762078 SGTC_25 0118-0223 35.662 µM 0.5155010486649 0.288844697102252 no 997 0.303101468493225 1512 5333628 SGTC_51 1013-0126 23.419 µM 0.514206934238387 0.289309049884213 no 998 0.303553660100059 1569 1627850 SGTC_2160 5660466 132.927 µM 0.514192537626476 0.289314217633884 no 999 0.30355869228201 1472 2859134 SGTC_2893 9048488 25.97 µM 0.512874634620881 0.289787470412396 no 1000 0.304019508895224 1392 6467338 SGTC_1575 cyproterone acetate 48 µM 0.512776662336861 0.289822666298233 no 1001 0.304053778233144 1391 9880 An androgen receptor antagonist and liver toxin. SGTC_1225 1216-0074 20.6 µM 0.512042512339824 0.29008646855242 no 1002 0.304310628429402 1427 4241466 SGTC_317 4495-0002 170 µM 0.511016262533309 0.29045541958343 no 1003 0.304669834684239 1424 15991618 SGTC_884 0851-0618 334 µM 0.510161798621506 0.290762778682827 no 1004 0.304969056493028 1498 9642473 SGTC_2623 humulene 100 µM 0.509423854511747 0.291028346785984 no 1005 0.305227579625352 1399 6187145 An anti-inflammatory. SGTC_98 0074-0023 107.663 µM 0.508709540772771 0.291285518772017 no 1006 0.305477916942216 1413 3563821 SGTC_2806 7952793 58.44 µM 0.508305398581046 0.291431067700508 no 1007 0.305619592312285 1501 2972490 SGTC_1583 clindamycin 39.6 µM 0.507988774906202 0.291545121156639 no 1008 0.305730607681805 1401 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1091 telmisartan 47.6 µM 0.506420785783414 0.292110245151873 no 1009 0.306280642900405 1552 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2885 9057732 51.95 µM 0.503571266012534 0.293138552738135 no 1010 0.307281344346605 1470 6471414 SGTC_1728 st035614 33.7865 µM 0.502693181741422 0.293455765447594 no 1011 0.307590002077275 1520 15945546 SGTC_191 3914-0123 66.505 µM 0.502334429310052 0.293585412448053 no 1012 0.307716147317689 1396 3144412 SGTC_3092 9117248 49.47 µM 0.501525663981782 0.293877783662285 no 1013 0.308000610365147 1562 17141857 SGTC_2975 9084847 53.72 µM 0.500785815217242 0.294145359209134 no 1014 0.308260934806673 1483 27211724 SGTC_1921 5740136 50 µM 0.500440103894656 0.294270428608119 no 1015 0.308382610456265 1598 1774243 SGTC_3200 9114385 49.47 µM 0.500174011728267 0.29436671058497 no 1016 0.308476277895387 1435 17018030 YLR208W SEC13 SGTC_922 1866-0035 480 µM 0.499462480771933 0.294624240196547 no 1017 0.30872680603211 1536 3156169 SGTC_1420 4'-methoxyflavone 42 µM 0.498454134871814 0.294989376119229 no 1018 0.309081994407327 1522 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2575 plumbagin 510 nM 0.495924620771063 0.295906264209262 no 1019 0.309973797299824 1418 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3100 9120536 49.47 µM 0.494608375031264 0.296383888764135 no 1020 0.310438294619161 1458 16421196 SGTC_1037 k284-1091 78.7 µM 0.49145413997595 0.297529898121865 no 1021 0.311552640138541 1467 3334711 SGTC_2789 5281112 71.43 µM 0.490068997353764 0.298033792163193 no 1022 0.312042537712783 1449 765948 SGTC_1513 0337-0559 19 µM 0.489933762669854 0.298083009337611 no 1023 0.312090385384488 1433 775073 SGTC_2323 6148992 148.28 µM 0.488750110836032 0.298513944354789 no 1024 0.312509310997588 1456 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_949 1165-0505 146 µM 0.486219794759656 0.299436111876382 no 1025 0.313405669080379 1479 6244267 SGTC_410 α-linolenic acid 100 µM 0.484882189090775 0.299924120292201 no 1026 0.31387995863379 1551 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2596 sinensetin 100 µM 0.484213502194992 0.300168217080279 no 1027 0.314117177707896 1476 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3278 9139605 49.47 µM 0.483766731334971 0.300331355906851 no 1028 0.314275714087237 1558 7958859 SGTC_1843 st055809 45.5 µM 0.483085962758099 0.300580016246966 no 1029 0.314517350303241 1492 16413835 SGTC_1376 2910-0861 41.3 µM 0.481538091396762 0.301145743784071 no 1030 0.315067057020822 1539 1112859 SGTC_938 3126-1755 342 µM 0.480675191281165 0.30146133106359 no 1031 0.315373682966357 1535 1777771 SGTC_1801 st050089 28.441 µM 0.479894653057501 0.301746924380221 no 1032 0.315651151727972 1506 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1939 st074455 53.6 µM 0.479257164812817 0.301980266938985 no 1033 0.315877845654121 1630 1644229 SGTC_2006 4011487 200 µM 0.478265701237575 0.302343337567315 no 1034 0.316230552550662 1629 45595294 SGTC_29 0299-0004 12.984 µM 0.477195357924568 0.302735513336931 no 1035 0.316611508187568 1456 16871 A napthoquinone isolated from Swertia calycina. SGTC_1511 0906-3109 28.5 µM 0.473161189113365 0.304215683616027 no 1036 0.318049092338489 1518 2882180 SGTC_225 nsc-122657 1.016 µM 0.472451426341069 0.304476434653501 no 1037 0.318302302377711 1525 275685 SGTC_788 1182-0090 188 µM 0.469439231875483 0.305584152745964 no 1038 0.319377855748378 1679 5715185 SGTC_2867 9039098 71.43 µM 0.469061910575093 0.305723036380196 no 1039 0.319512691919337 1491 6463460 SGTC_1687 st020778 55.3625 µM 0.468706035208775 0.305854051853054 no 1040 0.319639886233204 1541 4259299 SGTC_177 1327-0068 8.361 µM 0.467293033985422 0.306374493161427 no 1041 0.320145119818817 1495 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2824 7998404 51.95 µM 0.466073664261494 0.306823929728226 no 1042 0.32058138668245 1555 837851 SGTC_3188 9110789 49.47 µM 0.46605847835239 0.306829528799462 no 1043 0.320586821471142 1594 849217 SGTC_1855 st056195 39.6 µM 0.465350506478482 0.307090609273173 no 1044 0.320840235715716 1613 4028379 SGTC_2727 riluzole 51.77 µM 0.465093170951169 0.307185531758725 no 1045 0.320932368106434 1530 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1038 k292-0204 154 µM 0.464639729766627 0.307352822515185 no 1046 0.321094737934158 1482 4454212 SGTC_1712 st032288 53.4 µM 0.463138597897979 0.307906929929654 no 1047 0.321632512525187 1509 2883011 SGTC_261 5-fluorouridine 15.376 µM 0.462601924580095 0.308105136649096 no 1048 0.321824864439388 1594 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1675 st018485 24.5 µM 0.459913441616095 0.309098901550552 no 1049 0.322789175832363 1546 3323024 SGTC_1147 3809-1045 12.3 µM 0.459494755754099 0.309253789711166 no 1050 0.322939458570066 1501 325925 SGTC_2036 5160441 105 µM 0.459371223696212 0.309299495495542 no 1051 0.322983804584152 1574 134534 YIL048W NEO1 SGTC_1021 4476-0760 85.3 µM 0.458298735108982 0.30969643088434 no 1052 0.323368916379347 1501 746768 SGTC_429 1112-0049 25.5 µM 0.457787956249237 0.309885551729137 no 1053 0.323552394667846 1489 2836170 SGTC_1251 0490-5699 265 µM 0.456728012639103 0.310278166691605 no 1054 0.323933276808558 1650 3883818 SGTC_117 lucigenin 22.078 µM 0.456627326429701 0.310315473246418 no 1055 0.323969467178601 1478 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_899 1083-0020 478 µM 0.455353360919584 0.310787675232073 no 1056 0.324427521407179 1625 767123 SGTC_2959 9079155 11 µM 0.454685567713481 0.311035320893986 no 1057 0.324667732634357 1540 16189457 SGTC_1385 3091-4834 14.1 µM 0.454606159403598 0.311064774513715 no 1058 0.324696301372762 1598 4072814 SGTC_3330 9141424 71.43 µM 0.453528579619533 0.311464583045707 no 1059 0.325084084295327 1636 27261020 SGTC_789 1309-1135 70.6 µM 0.452986859943883 0.311665658383221 no 1060 0.325279101706151 1506 3092424 SGTC_2316 5844804 197.44 µM 0.452793782179352 0.311737338507004 no 1061 0.32534862067698 1656 776813 SGTC_1784 st039334 36.3 µM 0.451772383108097 0.312116651558574 no 1062 0.325716483477406 1649 3496984 SGTC_3105 9121040 49.47 µM 0.451058549566171 0.312381863511411 no 1063 0.325973675580588 1491 41448907 SGTC_882 0843-0131 351 µM 0.450649677724096 0.312533816257331 no 1064 0.326121028203227 1560 5425421 SGTC_3051 9093778 49.47 µM 0.445106333410488 0.314597076450945 no 1065 0.328121456037211 1564 17217378 SGTC_1868 st057644 42.7 µM 0.444713674299349 0.314743446941063 no 1066 0.328263343019262 1535 688665 SGTC_2771 fluoxetine 41.05 µM 0.444671673726901 0.314759105106364 no 1067 0.328278521351914 1603 3386 A selective serotonin reuptake inhibitor. SGTC_1189 1431-2119 7.28 µM 0.443524451662602 0.315186927818636 no 1068 0.32869321853765 1568 3107275 SGTC_1710 st031758 61.5 µM 0.441360620418681 0.315994539685887 no 1069 0.329475973159305 1635 5394341 SGTC_1581 himbacine 57.9 µM 0.440734962201597 0.316228219572672 no 1070 0.32970244126458 1545 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.43996411929618 0.316516226082791 no 1071 0.329981547417619 1605 279621 SGTC_229 benomyl 22.8748 µM 0.439249675477258 0.316783259848542 no 1072 0.330240317175825 1543 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_374 0880-0231 82.3 µM 0.438869166798799 0.316925519481418 no 1073 0.330378169618809 1575 6833587 SGTC_2266 7929956 200 µM 0.438390019125643 0.317104695481882 no 1074 0.330551790198837 1549 2967153 SGTC_453 enantio-paf c16 10 µM 0.437833265988991 0.317312945708757 no 1075 0.330753577159497 1558 13871343 A lipid and platelet activating factor SGTC_351 caspofungin 25 nM 0.436522976018887 0.317803280136408 no 1076 0.331228666464604 1654 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1793 st048256 72.231 µM 0.436468859424508 0.317823538433818 no 1077 0.33124829408931 1540 672022 SGTC_557 1315-0110 16.2 µM 0.434660085317581 0.318500958065446 no 1078 0.331904587366121 1519 6833801 SGTC_783 0848-0141 92.7 µM 0.433755826986803 0.318839847481067 no 1079 0.332232880939301 1537 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3275 9138069 49.47 µM 0.430834365328119 0.319935759831169 no 1080 0.333294405045677 1622 17617007 SGTC_887 0885-0007 9.62 µM 0.4308227336891 0.319940126296662 no 1081 0.333298634122542 1657 5719458 SGTC_2109 5483026 200 µM 0.430050300900498 0.320230149936293 no 1082 0.333579525671698 1605 759335 SGTC_1658 st012944 20 µM 0.428129541867931 0.320951809046705 no 1083 0.334278404919526 1633 24207260 SGTC_2460 5552655 174.22 µM 0.428067124343572 0.320975271654096 no 1084 0.334301125552433 1525 5401989 SGTC_2310 7668677 200 µM 0.427988245635549 0.321004923006026 no 1085 0.334329839097017 1623 2197143 SGTC_3149 9097855 49.47 µM 0.426939342977601 0.321399325211728 no 1086 0.334711754295555 1724 25236625 YMR079W SEC14 SGTC_1837 st055472 66.5 µM 0.42669046794679 0.321492935323831 no 1087 0.334802397128315 1639 676091 SGTC_3123 9126162 49.47 µM 0.425287106965815 0.322020997766634 no 1088 0.335313695601189 1611 25239884 SGTC_1922 5578187 25 µM 0.425278863184032 0.322024100834019 no 1089 0.335316700031144 1686 1350412 SGTC_380 3970-0968 6 µM 0.425077457009386 0.322099916609183 no 1090 0.335390105384717 1543 2891601 SGTC_1490 4089-0339 670 nM 0.423962943985259 0.32251958899975 no 1091 0.335796419101591 1672 742542 SGTC_1316 1272-0050 65.9 µM 0.423571909685525 0.322666887488813 no 1092 0.335939022497908 1593 7340392 SGTC_1050 3232-1156 69.3 µM 0.423343999843778 0.32275275155805 no 1093 0.336022148143471 1555 700529 SGTC_957 1187-1561 14.1 µM 0.421996482290409 0.323260616103824 no 1094 0.336513792532008 1574 1538454 SGTC_2090 5301565 104.445 µM 0.421774480469687 0.323344317792352 no 1095 0.336594817177092 1595 2056344 SGTC_2949 9072542 2.23 µM 0.421611351291693 0.323405828337401 no 1096 0.336654359739905 1557 16457352 SGTC_3 0833-0587 95.581 µM 0.421379117877131 0.323493404100418 no 1097 0.336739132588655 1574 5382644 SGTC_3101 9120531 49.47 µM 0.421174738074121 0.323570484291108 no 1098 0.336813744814767 1674 24824904 SGTC_718 1130-0073 349 µM 0.420388704515664 0.323867001017178 no 1099 0.337100759190417 1660 6740020 SGTC_1039 k821-0043 94 µM 0.420243465055504 0.323921802180883 no 1100 0.337153802698826 1699 15992768 SGTC_1476 4112-3294 3.34 µM 0.419805698406056 0.324087001601573 no 1101 0.337313700863239 1687 704369 SGTC_3024 9090631 49.47 µM 0.419188388851194 0.324320013759484 no 1102 0.33753922860544 1686 25236383 SGTC_1808 st050063 61.5 µM 0.418876374632269 0.324437814093384 no 1103 0.337653242024809 1666 4011993 SGTC_1335 1486-0900 202 µM 0.418141425663986 0.324715362002123 no 1104 0.33792185931791 1587 X1335 SGTC_2686 alizarin 95.37 µM 0.41625134190001 0.325429584634966 no 1105 0.338613046974348 1536 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1616 st002734 56.1 µM 0.416078255367641 0.325495022475506 no 1106 0.338676370477148 1624 4026101 SGTC_1819 st053448 58.6 µM 0.415043100235893 0.325886489916076 no 1107 0.339055175897926 1635 2857616 SGTC_586 0957-0265 8.15 µM 0.413728596448445 0.326383876118191 no 1108 0.339536440928251 1613 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_417 st075190 100 µM 0.41311811595666 0.326614976797857 no 1109 0.339760038606281 1710 222757 SGTC_1267 0828-0272 9.49 µM 0.411317540652539 0.327296981618536 no 1110 0.340419854661457 1727 745334 SGTC_1954 st077032 68.9 µM 0.410981981568256 0.327424145347621 no 1111 0.340542873493405 1532 698907 SGTC_3295 9122362 53.5725 µM 0.408956107837441 0.328192297011612 no 1112 0.341285936152862 1605 4730473 SGTC_602 3130-1533 38.1 µM 0.408606198074427 0.328325046215677 no 1113 0.34141434069279 1702 720941 SGTC_2816 7982706 58.44 µM 0.405094279949264 0.329658600441743 no 1114 0.342704105448836 1596 2981853 SGTC_1229 0139-0193 12.2 µM 0.403990514923756 0.330078173549035 no 1115 0.343109847052841 1726 3090752 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.401241587538291 0.331124049022502 no 1116 0.344121132411991 1583 2374 Ca(2+)-ATPase inhibitor. SGTC_3089 9117425 49.47 µM 0.399526450110619 0.331777270576372 no 1117 0.344752669185281 1566 9401657 SGTC_572 0960-0087 17.7 µM 0.399264456091142 0.331877097857948 no 1118 0.344849177076327 1552 6796365 SGTC_1938 st074717 56.4 µM 0.398112415954595 0.332316199962368 no 1119 0.345273661311295 1571 17250979 SGTC_2652 actinonin 100 µM 0.396605706368354 0.332890832414811 no 1120 0.345829121948022 1649 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2005 4024620 188 µM 0.396489046065948 0.33293534099263 no 1121 0.345872143571852 1599 236743 SGTC_2203 7227154 166.4 µM 0.395181542473597 0.333434344475061 no 1122 0.3463544567065 1639 896304 SGTC_2846 9008642 19.48 µM 0.395177975763564 0.333435706099291 no 1123 0.346355772739038 1615 2992898 SGTC_2149 5554786 194.827 µM 0.394686479166844 0.333623360409039 no 1124 0.34653714121514 1649 745063 YPR165W RHO1 SGTC_1652 st011932 78 µM 0.394364965973465 0.333746137268362 no 1125 0.346655802699494 1712 1551076 SGTC_961 1252-1571 372 µM 0.393119144300287 0.334222049628852 no 1126 0.347115742484533 1744 6813498 SGTC_567 1080-0542 68.4 µM 0.392760764328265 0.33435900263403 no 1127 0.347248093070534 1717 5950415 SGTC_1009 4106-0057 9.87 µM 0.392157111306525 0.334589735276908 no 1128 0.347471065696534 1696 2928005 SGTC_1054 3429-0080 167 µM 0.391976973968399 0.3346586007875 no 1129 0.347537613645987 1707 1162877 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.391721602119023 0.334756237568215 no 1130 0.347631963455044 1738 23847180 SGTC_1170 0310-0127 64.8 µM 0.391486672491039 0.334846068504764 no 1131 0.347718769006682 1683 774975 SGTC_2491 paeonol 100 µM 0.390327688636876 0.335289371813447 no 1132 0.348147125646788 1617 11092 Increases levels of cortical cytochrome oxidase. SGTC_2636 apigenin dimethyl ether 100 µM 0.389970020628647 0.335426223715834 no 1133 0.348279357732356 1664 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2725 haloperidol 53.21 µM 0.389950176401138 0.335433817207547 no 1134 0.348286694806805 1618 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_592 k241-0073 46.5 µM 0.387446249075823 0.336392495865279 no 1135 0.349212935198389 1717 4230158 SGTC_924 2046-0044 21.3 µM 0.387339373510158 0.33643343904811 no 1136 0.3492524901186 1582 3623589 SGTC_1464 k208-0027 110 µM 0.386295519744102 0.336833433081324 no 1137 0.34963890910875 1744 X1464 SGTC_3300 9124615 50.48 µM 0.385597980870236 0.337100825744852 no 1138 0.349897214416273 1716 24824903 SGTC_3265 9137266 49.47 µM 0.384569727276758 0.337495143790904 no 1139 0.350278113224176 1794 17224265 SGTC_313 3474-0040 5.03 µM 0.384359989044593 0.337575596826343 no 1140 0.350355825644267 1617 1043375 YIL048W NEO1 SGTC_1647 st011722 22.4 µM 0.383930142667357 0.337740503866085 no 1141 0.350515112328955 1660 2854783 SGTC_2276 7947513 42.08 µM 0.383067153619889 0.338071676580255 no 1142 0.350834986541762 1510 2105100 SGTC_1831 st055328 12 µM 0.382990779253561 0.338100991343672 no 1143 0.350863300445796 1760 1103068 SGTC_2728 chlorpromazine 9.18 µM 0.382782083721514 0.338181099929217 no 1144 0.350940673366749 1676 2726 A thorazine and dopamine antagonist. SGTC_562 3772-2733 112 µM 0.381612175137545 0.338630309423216 no 1145 0.351374526028152 1731 2876874 YIL048W NEO1 SGTC_675 1309-0189 238 µM 0.381445645396171 0.33869427049168 no 1146 0.351436298216192 1626 4246530 SGTC_3220 9131269 49.47 µM 0.381251073600514 0.338769007900304 no 1147 0.351508477234903 1652 17722206 SGTC_2195 6536160 144.242 µM 0.381041274422277 0.338849601445941 no 1148 0.35158631105492 1599 3834386 SGTC_3176 9106582 49.47 µM 0.380788613746747 0.338946669862726 no 1149 0.351680054407101 1675 17018027 SGTC_226 1,3-diallylurea 8.28947 mM 0.379959233330061 0.339265380437033 no 1150 0.351987838400727 1686 74537 YKL182W FAS1 SGTC_271 rotenone 740 µM 0.376747977068805 0.340500470712056 no 1151 0.35318045246737 1720 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2499 avocadenofuran 51.48 µM 0.376415073038915 0.340628608054788 no 1152 0.353304170975615 1586 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_573 3702-0553 84.7 µM 0.375111850022176 0.341130405541716 no 1153 0.353788642199117 1667 1222756 SGTC_2810 7959871 45.46 µM 0.374780950130941 0.341257861161592 no 1154 0.353911691481837 1739 2974535 SGTC_2097 5376186 200 µM 0.370057581086112 0.343079170992882 no 1155 0.355669793691121 1770 742755 SGTC_1087 pterostilbene 9.05 µM 0.367819095161961 0.343943599204693 no 1156 0.356504064889448 1777 5281727 Similar to reservatol, lowers cholesterol. SGTC_2343 7990716 14.84 µM 0.366337326911571 0.344516257771096 no 1157 0.357056689859803 1715 6456862 SGTC_295 k015-0027 31 µM 0.366047511033858 0.344628304562578 no 1158 0.357164811710336 1682 3887424 SGTC_2226 7298446 200 µM 0.365815876162835 0.344717867581725 no 1159 0.357251236172511 1768 3283010 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.364671319181784 0.345160545111593 no 1160 0.35767838517387 1743 5282309 SGTC_2583 asiatic acid 100 µM 0.364313050029046 0.345299155589716 no 1161 0.357812127995336 1702 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2373 9071805 200 µM 0.36410478332328 0.345379741275571 no 1162 0.357889882531735 1829 10149009 SGTC_216 k038-0035 28.382 µM 0.359999657190912 0.346969585076043 no 1163 0.35942369496197 1761 4444231 YPR107C YTH1 SGTC_395 anisomycin 6.25 µM 0.356230027811136 0.348431874141632 no 1164 0.360834153025392 1688 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2701 st077767 14.721 µM 0.356073000995297 0.348492836000307 no 1165 0.360892947983665 1686 5721188 SGTC_2699 st077704 54.6 µM 0.353791893313118 0.349378861442982 no 1166 0.361747424641788 1697 645852 SGTC_1799 st045822 46.1415 µM 0.352570743689494 0.349853516974859 no 1167 0.36220513697759 1806 3674992 SGTC_858 0438-0351 2.77 µM 0.350494944164853 0.350660909562732 no 1168 0.362983641897352 1660 2799119 SGTC_2754 granisetron 64.02 µM 0.348960803009245 0.351258055453916 no 1169 0.363559368317954 1829 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_632 0781-2353 4.65 µM 0.348128877973885 0.351582025943746 no 1170 0.363871698849672 1747 6811515 YHR007C ERG11 SGTC_2116 5511452 16.8835 µM 0.346857178714981 0.352077462833421 no 1171 0.36434930908349 1732 870744 SGTC_1195 1502-0147 41.1 µM 0.344965766547149 0.352814795977348 no 1172 0.365060053553444 1684 817940 SGTC_1767 st044992 70.3 µM 0.34296129971705 0.353596805227906 no 1173 0.365813787347477 1647 9600693 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.34267688837469 0.353707813726309 no 1174 0.36592077576456 1762 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1455 4262-0120 131 µM 0.342319606739686 0.353847281834491 no 1175 0.366055190935623 1794 1529587 SGTC_47 0149-0135 24.25 µM 0.340181844515895 0.354682185832047 no 1176 0.366859794863085 1603 5239155 SGTC_171 k064-0041 9.68 µM 0.339955695010013 0.354770549550314 no 1177 0.366944946564802 1655 53325 SGTC_3168 9103419 49.47 µM 0.339935517022862 0.354778434103735 no 1178 0.366952544467318 1786 16649256 SGTC_3207 9114163 49.47 µM 0.338552892729803 0.355318842889477 no 1179 0.367473287507445 1882 849233 SGTC_1506 4226-2149 212 µM 0.338543573788427 0.35532248625436 no 1180 0.367476798163919 1762 991114 SGTC_3239 9133757 49.47 µM 0.33781297400766 0.355608165152265 no 1181 0.36775206611447 1778 17036923 SGTC_3006 9075424 71.4286 µM 0.337759822013306 0.355628951796192 no 1182 0.367772094834972 1662 7465181 SGTC_1416 3966-0321 25.3 µM 0.33740105159786 0.35576927070088 no 1183 0.367907296010595 1741 582530 YLR208W SEC13 SGTC_3184 9108758 49.47 µM 0.337084216594691 0.355893204474351 no 1184 0.36802670760593 1716 902885 SGTC_1371 2421-0008 32.7 µM 0.336980007559459 0.355933970405024 no 1185 0.368065985622208 1721 2827552 SGTC_677 0929-0063 136 µM 0.336342995439638 0.356183201405553 no 1186 0.368306115431772 1692 1539583 SGTC_2099 5377090 177.372 µM 0.335675091860118 0.356444584687387 no 1187 0.368557945425726 1698 2243829 SGTC_626 0214-0009 33 µM 0.334548196499201 0.356885746712745 no 1188 0.368982964128748 1813 3437874 SGTC_1735 st034310 56.75 µM 0.333740908303747 0.357201905247544 no 1189 0.369287538676004 1819 871153 SGTC_1044 1222-0021 1.78 µM 0.333136297972358 0.357438753224441 no 1190 0.369515700463684 1771 4306703 SGTC_2790 5423970 71.43 µM 0.331414545940363 0.35811352709262 no 1191 0.370165689537681 1834 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_209 4077-0173 175.592 µM 0.331407415971491 0.358116322330545 no 1192 0.370168381988102 1752 15993494 SGTC_2487 5918373 44.05 µM 0.331064113116646 0.358250920015672 no 1193 0.370298029058162 1843 2876279 SGTC_878 0828-0289 13.7 µM 0.331058394629891 0.358253162194242 no 1194 0.370300188748625 1715 745350 YLR208W SEC13 SGTC_1109 tnp00067 928.257 nM 0.329134428994461 0.359007812660472 no 1195 0.371027041038214 1710 676295 SGTC_3035 9091303 49.47 µM 0.328932096236964 0.359087207094208 no 1196 0.37110350684553 1735 25237002 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.328053836481205 0.359431902650347 no 1197 0.371435478644656 1833 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1460 k062-0059 9.15 µM 0.328007324229165 0.359450160768696 no 1198 0.371453062394979 1669 1373085 SGTC_1539 benzyladenosine 56 µM 0.327878456788542 0.359500748621046 no 1199 0.37150178155978 1723 92208 A nucleotide analog. SGTC_1862 st057513 3.81 µM 0.327754097602875 0.359549569059825 no 1200 0.371548798301609 1706 5393163 SGTC_3198 9112019 49.47 µM 0.327551207331956 0.35962922384309 no 1201 0.371625509571363 1753 45595555 SGTC_715 0868-0130 184 µM 0.32738991898093 0.359692550051039 no 1202 0.371686495108758 1887 2876258 SGTC_2680 butyl paraben 22.24 µM 0.327212435052591 0.359762239536769 no 1203 0.371753608157732 1756 7184 An antifungal and steroid mimetic. SGTC_865 0488-0499 301 µM 0.326730684756469 0.359951423433819 no 1204 0.37193579489311 1832 9634651 SGTC_574 1315-0397 40 µM 0.323540602599888 0.361205036277894 no 1205 0.373142931560964 1747 6794277 SGTC_387 norethindrone acetate 66.7 µM 0.32198433859468 0.361817146745163 no 1206 0.373732279613172 1709 541197 SGTC_3066 9117245 49.47 µM 0.321732577293295 0.361916202892992 no 1207 0.37382764793365 1830 17176980 SGTC_1185 1319-0113 81.3 µM 0.320510518147981 0.36239715661532 no 1208 0.374290679127786 1799 4672763 SGTC_2541 muurolladie-3-one 83.07 µM 0.320503205619766 0.362400035189336 no 1209 0.37429345034933 1781 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1984 st072354 53.1 µM 0.320250452149599 0.362499536279631 no 1210 0.37438924007156 1776 5762938 SGTC_1605 st000082 49.1 µM 0.320049955697725 0.362578472032264 no 1211 0.374465230693638 1814 1114022 SGTC_1898 st060199 18.6 µM 0.319641248373964 0.362739398803812 no 1212 0.374620150896798 1719 688866 SGTC_2271 7849410 118.62 µM 0.319368263493796 0.362846898948301 no 1213 0.374723636885546 1905 972430 SGTC_2953 9074162 66.49 µM 0.3188829281975 0.363038048362804 no 1214 0.374907645186352 1914 16451992 SGTC_2943 9068529 45.32 µM 0.318842510138614 0.363053968564158 no 1215 0.374922970430869 1756 3270634 SGTC_1417 3966-0327 90.4 µM 0.318490851588647 0.36319249274349 no 1216 0.375056316518584 1769 651118 SGTC_768 0384-0033 77.3 µM 0.318314061543674 0.36326214005788 no 1217 0.375123359521318 1695 3965305 YMR134W ERG29 SGTC_3005 9076496 71.4286 µM 0.317353006260102 0.363640831588154 no 1218 0.375487880567266 1826 21368410 SGTC_1554 st069299 38.7 µM 0.316808335473587 0.363855511327542 no 1219 0.375694519488954 1807 24207999 SGTC_2992 9074591 71.4286 µM 0.316770948347581 0.36387024887715 no 1220 0.375708704843308 1786 17741321 SGTC_1317 1273-0028 910 nM 0.315813940728324 0.36424755811655 no 1221 0.376071868047026 1746 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_3314 9135860 59.4275 µM 0.315805900499022 0.364250728610418 no 1222 0.376074919601476 1887 25252478 SGTC_3334 9142812 21.919 µM 0.314610978978211 0.364722023734653 no 1223 0.376528521084663 1805 45283678 SGTC_1977 st070720 65.3 µM 0.313920229675211 0.36499455903883 no 1224 0.376790812712634 1746 682188 SGTC_119 0121-0043 24.815 µM 0.310413747566406 0.36637909188391 no 1225 0.378123170541999 1808 1092378 SGTC_2137 5261020 140 µM 0.31016503282005 0.366477363121409 no 1226 0.378217729955802 1771 763655 SGTC_2878 9043973 25.97 µM 0.30725935229882 0.367626091776198 no 1227 0.379322986153353 1858 6465167 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.306431476597057 0.367953600696674 no 1228 0.379638072718548 1850 688751 SGTC_1696 st025591 34.7925 µM 0.305764367286552 0.368217580051828 no 1229 0.379892030337197 1772 2787147 SGTC_397 arbidol 50 µM 0.305227966438013 0.368429882387886 no 1230 0.380096266959571 1869 131410 A RNA synthesis inhibitor. SGTC_222 nsc-310342 10.666 µM 0.305083147583765 0.368487207198118 no 1231 0.380151413013381 1881 432556 SGTC_2598 perillyl alcohol 100 µM 0.304106993032624 0.368873682599518 no 1232 0.38052318966601 1830 10819 An apoptosis inducer. SGTC_39 0986-0283 58.349 µM 0.302789311558443 0.369395584338812 no 1233 0.38102521471799 1911 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_875 0709-0210 25.7 µM 0.302050223057752 0.369688424871997 no 1234 0.381306888685759 1920 6251364 SGTC_2896 9052656 71.43 µM 0.301682494372097 0.36983415395261 no 1235 0.381447057177503 1799 6469436 SGTC_777 1315-0167 517 µM 0.30152116576356 0.369898093592891 no 1236 0.38150855630364 1726 4221767 SGTC_2965 9082772 38.63 µM 0.301445559347629 0.369928060049467 no 1237 0.381537378808595 1926 16459634 SGTC_1414 3917-0015 5.4 µM 0.301288769526894 0.369990205908316 no 1238 0.381597151958924 1837 6618702 SGTC_237 nikkomycin 200 µM 0.300308954504347 0.370378646264643 no 1239 0.381970751789948 1880 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_334 1502-1024 68.5 µM 0.300267711965028 0.370394999464034 no 1240 0.381986479830735 1790 3296216 SGTC_1289 0976-0073 69.1 µM 0.298781631404 0.370984405659014 no 1241 0.382553333564728 1842 3391136 SGTC_1733 st037357 54.9 µM 0.298767594375845 0.370989974441812 no 1242 0.382558689080624 1661 1272339 YGL099W LSG1 SGTC_1447 4239-0816 81.9 µM 0.298308439725863 0.3711721455891 no 1243 0.382733881702732 1715 1341554 SGTC_2715 st079500 56.4 µM 0.298255516351301 0.371193144971786 no 1244 0.382754076408956 1732 28246688 SGTC_2507 purpurin 79.67 µM 0.297903637958392 0.371332775995543 no 1245 0.38288835563202 1680 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_667 1498-1044 59 µM 0.297855391093089 0.371351922450814 no 1246 0.382906768066475 1797 6739982 SGTC_698 k064-0052 127 µM 0.296769676017823 0.371782865536336 no 1247 0.383321179033388 1831 5088751 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.295148400098178 0.372426682985597 no 1248 0.383940258853029 1710 23665772 A membrane-active detergent. SGTC_2077 5212015 200 µM 0.29451994318486 0.372676342656594 no 1249 0.384180313196366 1778 780900 SGTC_2147 5545932 89.7195 µM 0.294106365054418 0.372840669161376 no 1250 0.38433831363191 1798 797404 SGTC_3235 9132602 49.47 µM 0.293873885191213 0.372933050270255 no 1251 0.384427137018631 1815 4912240 SGTC_470 aa-861 153 µM 0.293038345869325 0.373265130927943 no 1252 0.384746420896128 1774 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1787 fluconazole 80 µM 0.290821036265273 0.374146844728506 no 1253 0.38559409788765 1806 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2944 9067346 25.62 µM 0.289957367996033 0.374490461194666 no 1254 0.385924426264618 1850 6473075 SGTC_2478 5763493 32.33 µM 0.28942930374921 0.374700604385954 no 1255 0.386126436486121 1847 1365576 YLR208W SEC13 SGTC_2663 amphotericin b 100 µM 0.289155819110041 0.374809452242441 no 1256 0.386231069783051 1813 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_441 propafenone 146 µM 0.288823902044086 0.374941569809518 no 1257 0.386358070029779 1789 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1760 st045453 10.4495 µM 0.288519037990304 0.375062932021538 no 1258 0.386474729806382 1922 3323419 YIL048W NEO1 SGTC_1540 guanosine 70.6 µM 0.287712998114042 0.375383865039591 no 1259 0.386783219747672 1891 6802 Guanosine is a purine nucleoside SGTC_2107 5363541 170.161 µM 0.287111358451399 0.375623470262758 no 1260 0.387013527685116 1838 244052 SGTC_3139 9095020 49.47 µM 0.287106018262185 0.375625597227829 no 1261 0.387015572090238 1797 25236292 SGTC_2260 7964312 200 µM 0.286661115279143 0.375802812665161 no 1262 0.387185907009384 1920 231951 SGTC_3099 9120367 49.47 µM 0.286071963072949 0.376037526313059 no 1263 0.387411502407501 1794 24824940 SGTC_2734 clemastine 41.6 µM 0.285773688912702 0.376156373907245 no 1264 0.387525730652579 1859 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1115 galangin 695.678 nM 0.28567612970123 0.376195249008076 no 1265 0.387563094425456 1919 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3039 9090270 49.47 µM 0.284284144741189 0.376750059631751 no 1266 0.388096317887453 1941 17173750 SGTC_1722 st034304 3.6505 µM 0.283746185071618 0.37696454527683 no 1267 0.388302449063382 1770 4036148 YLR033W RSC58 SGTC_534 k292-0788 63.4 µM 0.282254513698196 0.377559476212452 no 1268 0.388874180451583 1977 4146317 SGTC_569 4130-2812 160 µM 0.28189867286036 0.377701441023683 no 1269 0.389010603595231 1940 743552 SGTC_1181 1222-0449 220 µM 0.281732479792754 0.377767750394328 no 1270 0.389074323795411 1882 658318 SGTC_235 0330-0087 5 mM 0.281025790855852 0.378049752409532 no 1271 0.389345309191843 1805 46494818 YHR062C RPP1 SGTC_3273 9137859 49.47 µM 0.280585601062886 0.378225441631105 no 1272 0.389514130620559 1918 2377234 SGTC_616 4092-0450 108 µM 0.279777802068761 0.378547917081774 no 1273 0.389823991619596 1845 787165 SGTC_1222 0366-0074 1.18 µM 0.278794966338352 0.378940381707217 no 1274 0.390201088821123 1937 286520 SGTC_1421 4029-0249 71.4 µM 0.278645456741199 0.379000094625995 no 1275 0.390258462151831 1946 2894095 SGTC_758 0868-0029 16 µM 0.277454761515222 0.379475751596479 no 1276 0.390715468882954 1936 762687 SGTC_1463 k081-0032 34.1 µM 0.27675608443925 0.379754942964324 no 1277 0.390983701987562 1790 977755 SGTC_1348 1493-0373 93.8 µM 0.275763271799901 0.380151778717042 no 1278 0.391364947550174 1858 3010129 SGTC_841 0251-0215 91.2 µM 0.274703184446366 0.380575644064864 no 1279 0.391772142210211 1874 3888614 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.272886867638067 0.381302213309639 no 1280 0.392470090822963 1825 4620898 SGTC_2114 5491910 81.25 µM 0.272592332386434 0.381420073813243 no 1281 0.392583303337785 1882 2849228 SGTC_2191 5911152 200 µM 0.271979417153244 0.38166537171138 no 1282 0.392818922857156 1823 2875902 SGTC_1254 0550-0035 264 µM 0.271920373210092 0.381689004497198 no 1283 0.392841622860227 1905 15121435 SGTC_1932 st074806 40.9 µM 0.271281401575083 0.381944785930816 no 1284 0.393087304854573 1879 17251235 SGTC_1880 MG-132 525 µM 0.2698715540758 0.382509332466256 no 1285 0.393629536009621 1919 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1677 st019204 53.9 µM 0.269742305983766 0.382561099916355 no 1286 0.393679255515467 1759 3945625 SGTC_1401 3807-4679 7.6 µM 0.26588849712025 0.384105617727824 no 1287 0.39516254214625 1823 3291456 SGTC_2569 tetrandrine 100 µM 0.264441787462489 0.384685902588061 no 1288 0.395719757705052 1757 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2540 epiandrosterone 100 µM 0.263506361581076 0.385061245790011 no 1289 0.396080160467479 1906 441302 A steroid. SGTC_1116 jasmonic acid  1.58368 µM 0.263359963330984 0.385119998403532 no 1290 0.396136573127341 1901 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2247 cerulenin 830 nM 0.261636880620457 0.385811704603863 no 1291 0.396800703769262 1932 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1660 st012960 28.1 µM 0.260041791300205 0.386452353583326 no 1292 0.397415768676346 1845 24207266 SGTC_2159 5658611 73.75 µM 0.25881151139767 0.386946692737144 no 1293 0.397890337807359 1937 793844 SGTC_2602 kawain 100 µM 0.258356006585251 0.387129765845699 no 1294 0.39806608296193 1944 5369129 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.257999085667489 0.387273234396539 no 1295 0.398203806437899 1925 17037758 SGTC_905 2-aminofluorene 215 µM 0.257766468294616 0.387366745968511 no 1296 0.398293572289256 1821 1539 An established DNA mutagen. YPR165W RHO1 SGTC_249 wiskostatin 11.211 µM 0.257183763061509 0.387601020619564 no 1297 0.398518458870306 1949 2775510 A n-wasp and actin depolymerizer. SGTC_1372 2752-0194 270 µM 0.25643810408936 0.387900869955123 no 1298 0.398806284219895 1847 823334 SGTC_3172 9105863 49.47 µM 0.256145629911215 0.388018499876784 no 1299 0.398919194676577 1897 2348785 SGTC_2218 6965428 192.983 µM 0.255352738878914 0.38833744365259 no 1300 0.399225334954003 1932 675684 SGTC_2815 7968870 71.43 µM 0.254568772326605 0.388652871567673 no 1301 0.399528090380403 1816 2977326 YHR190W ERG9 SGTC_3173 9105693 49.47 µM 0.254308816216483 0.388757480789506 no 1302 0.399628494649144 1908 17096658 SGTC_2433 5607874 27.82 µM 0.253649030356949 0.389023022140417 no 1303 0.399883357135424 1802 2252428 SGTC_959 1222-0044 107 µM 0.253443489644914 0.389105755878345 no 1304 0.399962762246592 2012 6083612 SGTC_79 0052-0007 94.094 µM 0.253400146652804 0.389123202834172 no 1305 0.399979507170961 1946 2801472 SGTC_3010 9080089 71.4286 µM 0.253383017201888 0.389130098053686 no 1306 0.399986124931845 1939 17027233 SGTC_1743 st037606 46.3785 µM 0.25313729615391 0.389229013446947 no 1307 0.400081059514633 1844 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2584 androsterone 48.74 µM 0.252926106303421 0.389314033989134 no 1308 0.400162657652253 1909 2754130 A steroid. SGTC_3203 9113543 49.47 µM 0.251884779073323 0.389733327591343 no 1309 0.400565062446173 1885 17018012 SGTC_3344 9148862 3.898 µM 0.250636928466012 0.390235947508646 no 1310 0.401047414010032 1949 4905352 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.250364520334649 0.390345694815581 no 1311 0.401152732350987 1940 66535 A nucleotide analog. SGTC_3008 9078912 71.4286 µM 0.250095685586327 0.390454011051715 no 1312 0.401256676194187 1828 16648731 SGTC_582 0987-0078 156 µM 0.249741067553758 0.390596903244042 no 1313 0.401393798477964 1952 1625765 SGTC_1822 st052468 42 µM 0.24877209562242 0.390987422656132 no 1314 0.401768538553304 1863 2873678 SGTC_1057 3448-5381 134 µM 0.24776480955417 0.391393500159585 no 1315 0.402158192000408 1955 5497911 SGTC_1738 st035555 74 µM 0.247755312434341 0.391397329394431 no 1316 0.4021618662816 1896 5331140 SGTC_846 0335-0850 148 µM 0.246034904484561 0.392091170475104 no 1317 0.402827606462388 1926 6819598 SGTC_2183 6420625 130.508 µM 0.245206169268749 0.39242552229584 no 1318 0.403148399899543 1888 2897619 SGTC_3293 9120939 62.045 µM 0.243357610611485 0.393171605979235 no 1319 0.403864189322912 1928 934087 SGTC_2568 diosmetin 100 µM 0.242925993274465 0.393345864626484 no 1320 0.404031364444179 2021 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3350 9150499 3.57 µM 0.242541297719532 0.393501197360518 no 1321 0.404180380477259 1883 4910996 YPR165W RHO1 SGTC_2956 9076196 2.52 µM 0.242447731108356 0.393538980338843 no 1322 0.40421662663105 1988 16423868 SGTC_252 miconazole 1.30953 nM 0.241310509627767 0.393998279897557 no 1323 0.404657233017977 1938 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3144 9087057 49.47 µM 0.240953848438677 0.394142358171632 no 1324 0.404795443171568 2068 17249618 SGTC_1143 3454-2408 5.08 µM 0.239855779718932 0.394586029265726 no 1325 0.405221031446669 1904 X1143 SGTC_951 1171-0579 82.7 µM 0.239705701382031 0.39464667856617 no 1326 0.40527920736344 1862 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_1430 4049-0248 69.1 µM 0.239698860611028 0.394649443103133 no 1327 0.405281859149294 1987 22774488 SGTC_506 n9-isopropylolomoucine 153 µM 0.238628041433502 0.395082254857598 no 1328 0.40569700963249 2044 6610355 SGTC_266 formosanin C 406 nM 0.238594442333843 0.395095837292465 no 1329 0.405710037530712 1968 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1794 st048918 76.9 µM 0.236178064234646 0.396072991310659 no 1330 0.406647250144368 2005 672303 SGTC_45 0kpi-0036 14.9 µM 0.236030849121687 0.396132544495253 no 1331 0.406704366109626 1907 2795021 SGTC_1804 st050076 49.1 µM 0.235835698409588 0.396211492887127 no 1332 0.406780083007193 1930 3895976 SGTC_2521 angolensin 13.4 µM 0.235604299213452 0.396305111150849 no 1333 0.406869868539001 1913 821428 A flavenoid. SGTC_2256 7954252 200 µM 0.235258470163784 0.396445035984682 no 1334 0.407004063284632 1873 2972920 SGTC_3355 9151058 44.0485 µM 0.235054885556789 0.396527413968307 no 1335 0.40708306691546 1985 17015728 SGTC_1902 st060212 70.5 µM 0.232327058835937 0.39763163936991 no 1336 0.408141998708564 2001 688944 SGTC_1274 0865-0114 173 µM 0.231324019996301 0.398037876766177 no 1337 0.408531543710929 1911 870624 SGTC_2418 pentamidine 31.67 µM 0.230761445605988 0.398265771556204 no 1338 0.408750067406871 2019 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2593 nobiletin 86.24 µM 0.228869726419842 0.399032347365067 no 1339 0.409485085445065 1842 72344 An anti-infammatory. SGTC_1489 4065-0444 182 µM 0.228569422985027 0.399154074350048 no 1340 0.409601796183696 2013 2877968 SGTC_757 1066-0008 322 µM 0.226300562859013 0.400074065297974 no 1341 0.410483830323595 1987 6842497 SGTC_732 3970-1727 52.7 µM 0.225961494227681 0.400211600650413 no 1342 0.410615684472665 2029 1275699 SGTC_1957 st077035 62.4 µM 0.22494974965169 0.400622064951339 no 1343 0.41100918315934 2007 705593 SGTC_1047 2043-3044 82 µM 0.222271216249248 0.40170927351644 no 1344 0.412051378888524 1875 669592 SGTC_2403 6032726 181.2 µM 0.219909875546351 0.402668366184484 no 1345 0.412970672500673 1898 2881040 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.218779562880505 0.403127666786309 no 1346 0.413410883841683 1926 364106 SGTC_535 2293-4129 48.2 µM 0.217548697338875 0.40362797891375 no 1347 0.413890380299049 2026 396118 YIL048W NEO1 SGTC_2153 5569715 200 µM 0.217496877459104 0.403649045699294 no 1348 0.41391057009327 1942 2054701 SGTC_3294 9122953 26.2835 µM 0.217288119640649 0.403733916658164 no 1349 0.413991907541844 1939 16459826 SGTC_1076 itraconazole 331 nM 0.21717942329497 0.403778109195841 no 1350 0.414034259912013 2023 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2606 farnesol 9.78 µM 0.21676768732006 0.403945519312057 no 1351 0.414194697499598 2016 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2704 st078022 71.1 µM 0.215739725551185 0.404363560985678 no 1352 0.414595316898855 2034 54697681 SGTC_2781 5567276 71.43 µM 0.214695087861486 0.40478849615376 no 1353 0.415002526300389 1967 2853274 SGTC_1098 clofazimine 15.1 µM 0.214606708798911 0.404824451932602 no 1354 0.415036981470269 2001 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2671 danthron 100 µM 0.214384787029643 0.404914741225502 no 1355 0.415123502039564 1930 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2259 7964009 200 µM 0.213609452120777 0.405230227412253 no 1356 0.415425813900234 1990 313134 SGTC_61 0978-8327 98.565 µM 0.212252188119754 0.405782650523647 no 1357 0.41595514694866 2068 6150059 YHR072W ERG7 SGTC_1821 st053465 65.6 µM 0.211201553202318 0.406210400764923 no 1358 0.416364999405129 1903 675086 SGTC_2546 rhodinyl acetate 100 µM 0.210847151677689 0.40635471530832 no 1359 0.416503271900711 2059 6708682 SGTC_765 1319-0117 244 µM 0.210505304192995 0.406493929821623 no 1360 0.416636656130903 1904 3487746 YGL099W LSG1 SGTC_1864 st057645 30.4 µM 0.209877980626976 0.406749432803658 no 1361 0.416881454196745 2065 688666 SGTC_650 1328-0195 38 µM 0.209741259245895 0.406805123407574 no 1362 0.416934810737337 2035 2780821 SGTC_196 k015-0023 18.111 µM 0.20901422444691 0.407101297505196 no 1363 0.417218567178675 1913 5211998 SGTC_1989 st071868 50.2 µM 0.208492773989342 0.407313754891426 no 1364 0.417422112097999 2044 16414057 SGTC_912 3474-0017 2.18 µM 0.207432826305825 0.407745699112644 no 1365 0.417835924191186 1996 3360550 SGTC_3317 9138495 8.753 µM 0.206918867447147 0.407955185296692 no 1366 0.41803661064549 2037 17020139 SGTC_1871 st057448 67.3 µM 0.205491379714937 0.408537157593085 no 1367 0.418594116194463 2013 691747 SGTC_2823 7987624 58.44 µM 0.204380339444424 0.408990257161295 no 1368 0.419028146387253 1950 2239440 SGTC_338 4055-0136 114 µM 0.204129198509588 0.409092693232346 no 1369 0.419126268792643 1898 2900563 SGTC_2821 7996764 71.43 µM 0.202623854669627 0.409706827017972 no 1370 0.419714521709823 1958 2987135 SGTC_1508 1080-0625 72.9 µM 0.202387386732218 0.409803318809262 no 1371 0.41980694415191 2042 767111 SGTC_3296 9122258 64.045 µM 0.202302865429788 0.409837809427376 no 1372 0.419839980000536 1939 4730474 SGTC_3241 9133421 49.47 µM 0.202198331826189 0.409880467432627 no 1373 0.419880838603552 2047 17018221 SGTC_1359 1582-0056 520 nM 0.202098129039575 0.40992135912219 no 1374 0.419920005249333 1994 3661189 SGTC_2733 amorolfine 100 µM 0.19963117481831 0.410928404754893 no 1375 0.420884522269844 2096 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_480 am 92016 50 µM 0.199334284199117 0.411049639434841 no 1376 0.421000631172769 1914 2129 K+ channel blocker. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.198787976605696 0.411272745221698 no 1377 0.421214300786948 2081 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_412 gemfibrozil 100 µM 0.198114799475262 0.411547702542177 no 1378 0.421477623009288 2046 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1807 st050092 58.9 µM 0.197643723148757 0.41174013819979 no 1379 0.421661911698245 1967 5008496 SGTC_2223 6903751 107.57 µM 0.196819566361463 0.412076858994523 no 1380 0.421984369430993 2018 5598863 SGTC_23 0213-0011 39.996 µM 0.196710349640251 0.412121485878663 no 1381 0.422027105249872 2069 627608 SGTC_1560 lithocholic acid 53.1 µM 0.19534317195204 0.41268022231707 no 1382 0.422562150840166 2065 9903 A bile acid which acts as a detergent. SGTC_2007 4011539 71.82 µM 0.19534072046362 0.412681224347525 no 1383 0.422563110359885 1948 45595301 SGTC_110 0850-0284 111.64 µM 0.194402518753628 0.413064750109702 no 1384 0.422930358931622 2078 3906265 SGTC_285 1486-1325 46 µM 0.194008176296878 0.413225977433689 no 1385 0.423084739891542 2050 22310230 SGTC_3022 9087993 49.47 µM 0.191521438595798 0.414243018792902 no 1386 0.424058542919777 2025 17173644 SGTC_2935 9038016 29.96 µM 0.190456703727265 0.414678656945516 no 1387 0.424475633787408 2096 6463195 SGTC_236 1509-0011 5.31 µM 0.190063421204553 0.414839595757393 no 1388 0.424629716608292 2028 3107280 SGTC_1337 1486-1011 40.3 µM 0.189997038632764 0.414866762199908 no 1389 0.424655725546897 2086 X1337 SGTC_2592 piperlongumine 83.33 µM 0.189749579662017 0.41496803604047 no 1390 0.424752683782121 1916 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1786 berberine 21.6 µM 0.189412905894359 0.415105830562778 no 1391 0.424884605058213 1987 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2673 kobusone 100 µM 0.189122094688884 0.415224862769889 no 1392 0.42499856245296 2018 6710676 An epoxy ketone and protein crosslinker. SGTC_2987 9018338 71.43 µM 0.188194492202129 0.415604592558193 no 1393 0.425362094967901 2085 5055682 SGTC_906 1165-0455 526 µM 0.18770697453392 0.415804197796163 no 1394 0.425553181285472 1947 3252859 SGTC_2122 5258151 111.688 µM 0.186045811285269 0.416484493682932 no 1395 0.426204418102866 1974 2173356 SGTC_2405 ticlatone 3.52 µM 0.185249415090175 0.416810730541348 no 1396 0.426516706064993 2007 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1419 3993-2473 62.6 µM 0.184773995518744 0.417005509410726 no 1397 0.426703152598538 2002 704026 SGTC_2759 disulfiram 3.38 µM 0.184633520916936 0.417063065600126 no 1398 0.42675824602622 1965 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1130 3454-2858 15.9 µM 0.184404595478443 0.417156866263584 no 1399 0.426848032485616 1891 715628 YIL048W NEO1 SGTC_976 1348-1067 47.6 µM 0.184345221785011 0.417181195006672 no 1400 0.426871319960792 2013 5310671 YGL099W LSG1 SGTC_3222 9128301 49.47 µM 0.183246621057849 0.41763141066348 no 1401 0.427302257660169 1979 4911358 SGTC_3238 9133470 49.47 µM 0.181756302680961 0.41824232795963 no 1402 0.427886989317993 2096 3534688 SGTC_2200 6600604 21.907 µM 0.18006369014483 0.418936409707242 no 1403 0.42855128385541 2021 2904777 SGTC_2887 9044784 58.44 µM 0.179671680556597 0.419097195329853 no 1404 0.428705163623032 2109 6465546 SGTC_2453 5731132 22.18 µM 0.178441189600997 0.419601977922557 no 1405 0.429188251859844 2082 1362040 SGTC_2382 9035899 200 µM 0.177026247332321 0.420182591242994 no 1406 0.429743886390076 1956 6462679 SGTC_1814 st052110 31.539 µM 0.175614891973651 0.420761905784999 no 1407 0.430298251040339 2076 674163 SGTC_116 0155-0182 31.788 µM 0.173898580710144 0.421466625775695 no 1408 0.430972584032086 1957 771486 SGTC_1632 st005650 90 µM 0.173447071528037 0.421652058022959 no 1409 0.431150014010422 1992 2759605 SGTC_2290 7904846 200 µM 0.173232423493449 0.421740218843087 no 1410 0.43123436932128 1946 2962154 SGTC_2883 9059145 45.46 µM 0.172180981910877 0.422172126354637 no 1411 0.431647624412611 1993 16476510 SGTC_725 1497-0963 19 µM 0.171846205943136 0.422309664133441 no 1412 0.431779219367193 2111 3549977 SGTC_1840 st055363 71 µM 0.170360409976514 0.422920195641855 no 1413 0.432363352613686 1936 676033 SGTC_664 1222-0054 14.9 µM 0.169620302864652 0.423224383779478 no 1414 0.432654377273577 2042 6813991 SGTC_3079 9117512 49.47 µM 0.167551140656115 0.424075063258502 no 1415 0.433468205886696 2100 7185044 SGTC_1851 st056236 18.9 µM 0.166753911130944 0.424402917042562 no 1416 0.433781842201441 2134 5393171 SGTC_1227 3909-8010 46.6 µM 0.166602270178829 0.424465284008246 no 1417 0.433841503660935 2024 15982272 SGTC_344 k064-0035 6.43 µM 0.166513647175358 0.424501733796612 no 1418 0.433876372101785 1918 5088750 SGTC_3026 9090633 49.47 µM 0.162194442611085 0.426278957738798 no 1419 0.435576368004861 2028 25236842 SGTC_2695 st077686 51.995 µM 0.161502037015569 0.426564002276228 no 1420 0.435849003555941 1991 2876092 SGTC_1011 4112-3381 17.4 µM 0.160818760362664 0.426845326282787 no 1421 0.436118074464069 2049 2877139 SGTC_1949 st076024 69.1 µM 0.160501866326954 0.426975813014445 no 1422 0.436242875785012 2070 2921930 SGTC_596 1155-0152 116 µM 0.16028418516103 0.427065451720688 no 1423 0.436328608111021 2010 280313 SGTC_1487 3970-0795 2.82 µM 0.159634525361086 0.427332996844892 no 1424 0.436584490211442 2066 3765103 SGTC_2809 7964133 12.99 µM 0.158062828452206 0.427980396462363 no 1425 0.437203645470569 2016 1253665 SGTC_1304 1165-0502 251 µM 0.157726894505836 0.428118796642413 no 1426 0.437336003503445 2052 767425 SGTC_2250 alverine citrate 130 µM 0.157520483821587 0.428203839401319 no 1427 0.437417332828102 1966 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3180 9109287 49.47 µM 0.157105165867346 0.428374963632306 no 1428 0.437580983184547 2037 18891271 SGTC_215 1287-0124 461.5 µM 0.15591884197016 0.428863840955792 no 1429 0.438048496601964 2154 5560863 SGTC_2441 5730946 39.09 µM 0.155184826523155 0.429166379254472 no 1430 0.438337805026415 2077 1774275 SGTC_2830 7992007 71.43 µM 0.155125403530373 0.429190873383983 no 1431 0.438361227738349 1946 1952075 SGTC_1701 st028638 40.4 µM 0.154450047354234 0.429469274016378 no 1432 0.43862744747578 2120 3490878 SGTC_1914 st062367 72.6 µM 0.150625379333178 0.43104656668117 no 1433 0.440135619995604 2023 978205 SGTC_2776 terbinafine 19.92 µM 0.148413264290609 0.431959346593957 no 1434 0.441008316303373 2149 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2716 st080858 38.6235 µM 0.147382153935641 0.43238493572775 no 1435 0.441415195396327 2140 5296050 SGTC_2141 5621638 7.665 µM 0.146827848847796 0.432613756717125 no 1436 0.441633951351563 2127 2856238 SGTC_548 1436-0017 110 µM 0.146741294916189 0.432649488823099 no 1437 0.441668111383971 2154 9677137 SGTC_2755 lomerizine 42.69 µM 0.146233815763343 0.432859002785875 no 1438 0.441868405684241 2035 3949 A calcium channel blocker. SGTC_2852 9023854 51.95 µM 0.144968537391892 0.433381458015495 no 1439 0.442367856428747 2098 19798528 SGTC_1500 4488-1866 171 µM 0.144501622285478 0.433574284765114 no 1440 0.442552187749087 2146 2900003 SGTC_2620 irigenin 100 µM 0.143941873925037 0.433805470657753 no 1441 0.442773184682195 2100 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_3028 9087778 49.47 µM 0.143583924139837 0.433953322075269 no 1442 0.442914517891324 2093 17217395 SGTC_2813 7971799 71.43 µM 0.143104247306899 0.434151467423258 no 1443 0.443103925301865 2052 2234054 SGTC_966 1300-0360 30.2 µM 0.140952323769461 0.435040588894539 no 1444 0.443953803166514 2037 70588 SGTC_2009 4012297 12.05 µM 0.140829242620234 0.435091452951147 no 1445 0.44400242050603 2019 45595307 SGTC_630 4356-0227 183 µM 0.140015636384606 0.435427707807314 no 1446 0.444323818019896 2141 779312 SGTC_3068 9116768 49.47 µM 0.13893877587942 0.435872834633437 no 1447 0.444749264696603 2064 41904888 SGTC_3166 9102297 49.47 µM 0.138270028212457 0.436149306471108 no 1448 0.445013505987908 2025 25237072 SGTC_1208 2323-2347 50.3 µM 0.1371119330226 0.436628156752679 no 1449 0.445471160182644 2196 5412760 SGTC_799 1310-0557 151 µM 0.136634703252828 0.436825509226552 no 1450 0.445659772254792 2059 5354492 SGTC_3266 9136860 49.47 µM 0.136452083426737 0.436901033561273 no 1451 0.445731951024564 2138 4871271 YPR165W RHO1 SGTC_2497 7-hydroxyflavone 100 µM 0.136411453148769 0.436917836949556 no 1452 0.445748010004721 2165 5281894 SGTC_1080 nisoldipine 24.4 µM 0.135589175023229 0.437257929398029 no 1453 0.446073031749302 2086 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_3126 9127922 49.47 µM 0.134080572198698 0.437882004643426 no 1454 0.446669431027023 2091 45595682 SGTC_1153 4055-0057 267 µM 0.132729512843339 0.4384410389029 no 1455 0.44720365074477 2020 882706 SGTC_5 0352-0601 109.883 µM 0.132578099392557 0.438503697642938 no 1456 0.447263526826944 2085 762456 SGTC_3169 9102970 49.47 µM 0.132039276340211 0.438726688829772 no 1457 0.447476612837301 2182 17027839 SGTC_352 k048-0007 5.11 µM 0.131058267391249 0.439132727944157 no 1458 0.44786460706774 2165 6811911 SGTC_1105 epirubicin 18.1 µM 0.129201877966209 0.43990126155401 no 1459 0.448598955132283 2031 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_511 blebbistatin 171 µM 0.128936245170317 0.440011250462523 no 1460 0.448704048265608 2162 3476986 A myosin inhibitor. SGTC_3340 9146634 11.102 µM 0.127830746909601 0.440469046838792 no 1461 0.449141458577189 2071 4907387 SGTC_50 0929-0078 56.389 µM 0.126565785687364 0.440992975802542 no 1462 0.449642039088741 2125 1377751 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.126514283683424 0.441014309395348 no 1463 0.449662421574582 2189 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1979 st071809 45.3 µM 0.124134805573216 0.442000142453955 no 1464 0.45060427020778 2144 4976333 SGTC_3191 9110352 49.47 µM 0.123225702085215 0.442376885070622 no 1465 0.450964186673974 2166 17122424 SGTC_2646 retinol 96.75 µM 0.122954608447461 0.442489239398887 no 1466 0.451071521177431 2156 445354 A vitamin A analog and teratogen. SGTC_115 0527-0192 112.043 µM 0.122466096501258 0.442691714072549 no 1467 0.451264947459324 2056 4233931 SGTC_566 0958-0068 16.5 µM 0.12071137981712 0.44341911862251 no 1468 0.451959822560658 2154 6815365 SGTC_2047 4141938 200 µM 0.120171918580853 0.44364278664463 no 1469 0.452173481134224 2093 3807862 SGTC_128 0906-2981 13.371 µM 0.117576749974349 0.444719028818991 no 1470 0.453201513987104 2201 6740226 SGTC_683 panaxydol 45 µM 0.11541062870694 0.445617653296823 no 1471 0.454059827383715 2167 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2168 5727979 200 µM 0.115094530225624 0.445748811551246 no 1472 0.454185097670717 2197 695210 SGTC_2881 9058953 51.95 µM 0.11507344865062 0.445757559107935 no 1473 0.454193452491745 2192 17122249 SGTC_3346 9158254 43.5805 µM 0.11430380950019 0.446076930051211 no 1474 0.454498481374847 2118 17639500 SGTC_861 0443-0273 110 µM 0.11391641864888 0.446237695754757 no 1475 0.454652025047143 2144 6149169 SGTC_868 0527-0199 213 µM 0.113623119790295 0.446359419525785 no 1476 0.454768279548772 2086 2849450 SGTC_1983 st071813 46.9 µM 0.113064227791799 0.446591382730242 no 1477 0.454989817588 2083 11838595 SGTC_2661 dactinomycin 12.96 µM 0.112921687748581 0.446650545648575 no 1478 0.455046320983121 2197 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_705 1124-0212 310 µM 0.111847343609263 0.447096502909437 no 1479 0.455472224115249 2219 9554485 SGTC_293 4049-0273 38.5 µM 0.111646449268072 0.447179901032551 no 1480 0.455551870519011 2158 1380311 SGTC_2293 7624732 200 µM 0.111493845945023 0.447243253460876 no 1481 0.455612372699876 2187 894453 SGTC_1755 st041960 45.185 µM 0.111264919935158 0.447338293355752 no 1482 0.455703136237005 2123 2257073 SGTC_3208 9114115 49.47 µM 0.110190465612426 0.447784399304578 no 1483 0.456129161783698 2007 650895 SGTC_1910 st062352 60.4 µM 0.109298385171053 0.448154835101342 no 1484 0.456482913685128 2165 2245730 SGTC_3158 9100007 49.47 µM 0.108703981139719 0.448401686091731 no 1485 0.45671864203893 2109 19297233 SGTC_2793 7325131 81.82 µM 0.108586572211723 0.448450447397139 no 1486 0.45676520579726 2143 4176441 SGTC_135 0933-0004 26.348 µM 0.108428660441726 0.448516031236064 no 1487 0.456827833704022 2091 21230617 YGL099W LSG1 SGTC_1833 st055984 71 µM 0.10703053295743 0.44909676203293 no 1488 0.457382378540275 2092 676288 SGTC_1386 3228-0095 33.8 µM 0.106642565891802 0.449257928684314 no 1489 0.457536274207932 2187 870181 SGTC_2211 7117706 200 µM 0.10570875824536 0.44964587900926 no 1490 0.457906715607452 2231 822771 SGTC_2920 7982904 15.77 µM 0.105212974738148 0.449851871819981 no 1491 0.458103407756945 2128 6456808 SGTC_2644 guaiazulene 100 µM 0.10479227186384 0.450026680021615 no 1492 0.45827032122234 2204 3515 A coloring agent. SGTC_3023 9089636 49.47 µM 0.104771698170733 0.450035228941186 no 1493 0.45827848400449 2247 17249241 SGTC_274 sirtinol 40.1 µM 0.104318473613879 0.450223561737044 no 1494 0.458458309036541 2040 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2050 5263056 171 µM 0.104307439414949 0.450228147024698 no 1495 0.458462687160505 2221 763468 YGL055W OLE1 SGTC_1202 1988-0068 29.6 µM 0.102703629989211 0.450894684206506 no 1496 0.459099096283958 2068 2850480 SGTC_1623 st003709 20.3 µM 0.101577172855205 0.451362918478446 no 1497 0.459546149567674 2134 16192618 SGTC_721 1187-1332 279 µM 0.100842007982088 0.451668540892572 no 1498 0.459837939620102 2201 25730 SGTC_2158 5657123 3.6195 µM 0.0997756637323176 0.452111891914538 no 1499 0.460261214574046 2238 2858827 SGTC_1646 st011709 75.6 µM 0.0991322918591622 0.452379413795172 no 1500 0.460516616580775 2238 5757843 SGTC_265 mycophenolic acid 32.932 µM 0.0983979313357424 0.452684796284286 no 1501 0.460808158632527 2203 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2350 9023895 38.85 µM 0.0968073066958166 0.453346350382379 no 1502 0.461439710643958 2175 2997209 SGTC_1315 1237-0019 3.69 µM 0.0961124576994456 0.453635384642197 no 1503 0.461715628650263 2233 825140 SGTC_1293 1000-1278 195 µM 0.0952596630311466 0.453990152643956 no 1504 0.462054290571438 2203 678847 SGTC_3058 9093861 49.47 µM 0.0939007895286685 0.454555528402148 no 1505 0.462593983328611 2200 17217477 SGTC_805 3852-0218 479 µM 0.0935129825396463 0.454716897130231 no 1506 0.462748018157001 2161 6615355 SGTC_666 0272-0154 136 µM 0.0931558105943886 0.454865525051478 no 1507 0.462889889854715 2161 6870312 SGTC_1108 betulinic acid 729.144 nM 0.092969693964808 0.454942975206811 no 1508 0.462963818815697 2207 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_524 r073-0010 27.8 µM 0.0924758102047699 0.45514850717837 no 1509 0.463160004756733 2124 2772106 SGTC_1394 3474-0001 65.7 µM 0.0914624906314733 0.455570242253107 no 1510 0.463562554706805 2173 5017666 YIL048W NEO1 SGTC_1888 azatryptophan 97.5 µM 0.0911613885638391 0.455695568069544 no 1511 0.463682177311998 2131 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1564 D-Arginine 115 µM 0.0907831223957462 0.455853017660004 no 1512 0.463832460522128 2123 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2563 tomatine 8.54 µM 0.0884246542904786 0.45683486234116 no 1513 0.4647695833761 2301 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_152 4469-0003 551.229 µM 0.0883646863900506 0.456859830805894 no 1514 0.464793413823938 2273 697280 SGTC_2795 7780010 54.55 µM 0.08723480844348 0.45733030284181 no 1515 0.465242435835551 2178 953673 SGTC_3054 9094397 49.47 µM 0.0865217787132799 0.457627233473992 no 1516 0.465525822038968 2212 2598354 SGTC_809 3998-0021 90 µM 0.0862096927710725 0.457757204477292 no 1517 0.465649862839531 2255 715485 SGTC_2292 7671323 168.05 µM 0.0858206201343142 0.457919243608339 no 1518 0.465804507227525 2153 937504 SGTC_2198 6589944 200 µM 0.0855017626130236 0.458052045096438 no 1519 0.465931247121079 2211 5290268 SGTC_1186 1319-0216 26 µM 0.0845625373903038 0.458443251696127 no 1520 0.466304591589494 2264 4565136 SGTC_2092 5303694 80.6725 µM 0.0822532510338111 0.459405287293557 no 1521 0.467222664331312 2179 1963699 SGTC_1466 k213-0079 57.5 µM 0.081315179867983 0.459796150645695 no 1522 0.467595651089176 2252 3657981 SGTC_2456 5770359 74.46 µM 0.0809651025344404 0.459942026314934 no 1523 0.467734852750624 2259 3118787 SGTC_3130 9127414 49.47 µM 0.0808847263834002 0.459975519461767 no 1524 0.467766813371551 2281 1494646 SGTC_1883 5-benzylidenerhodanine 20 µM 0.0803727097882112 0.460188886012434 no 1525 0.467970415552764 2279 1273210 SGTC_2210 7115885 190.385 µM 0.0791001925741312 0.460719216410274 no 1526 0.468476465171401 2253 2927039 SGTC_208 k072-0098 12.366 µM 0.0783854557302358 0.461017118665796 no 1527 0.468760721288892 2287 5948901 SGTC_2118 5526350 200 µM 0.0780355783139315 0.461162955529478 no 1528 0.468899875934531 2204 743594 SGTC_3325 9138760 55.175 µM 0.077580604257089 0.461352606872142 no 1529 0.469080835716604 2211 43844959 SGTC_108 0509-0257 621.132 µM 0.0775150588311811 0.461379929546588 no 1530 0.469106906051166 2247 536624 SGTC_2971 9092186 9.93 µM 0.0774472055328672 0.461408214451917 no 1531 0.469133894468886 2041 25236400 SGTC_1966 st070145 16.1 µM 0.0760295415360136 0.461999217508369 no 1532 0.469697797732234 2269 3748532 SGTC_3076 9116187 49.47 µM 0.0759768568330926 0.462021182603491 no 1533 0.469718755269796 2265 27241210 SGTC_1168 k815-0004 80.5 µM 0.075385690295776 0.462267657312395 no 1534 0.469953922150193 2243 642433 SGTC_2693 st077581 40.7 µM 0.0751685512432298 0.462358192610502 no 1535 0.470040303006942 2290 25238761 SGTC_1148 3909-7663 27.7 µM 0.0751633824522372 0.462360347741935 no 1536 0.470042359239218 2275 4084526 SGTC_853 0419-0306 21 µM 0.0749498934010048 0.462449363132864 no 1537 0.47012728948354 2129 762713 SGTC_3329 9141233 27.5565 µM 0.0724140496193497 0.463506839241964 no 1538 0.471136202084579 2253 4909101 YNL103W MET4 SGTC_585 0kpi-0023 191 µM 0.0719172381049076 0.463714045821773 no 1539 0.471333885773792 2268 64601 SGTC_2907 7721985 69.9 µM 0.0717621326822612 0.463778738096859 no 1540 0.471395604415963 2223 3267881 SGTC_305 1682-2595 20.8 µM 0.0715033417274892 0.463886678270176 no 1541 0.471498582526941 2201 226033 SGTC_1204 4049-0315 18.3 µM 0.0708870805273244 0.464143727851594 no 1542 0.471743812876695 2236 588402 SGTC_2782 7736369 71.43 µM 0.0697338041534853 0.464624812723348 no 1543 0.472202767719631 2200 2950836 YOL077C BRX1 SGTC_2177 5811945 192 µM 0.0691779395712731 0.464856708043297 no 1544 0.472423991352283 2234 5343475 SGTC_571 k831-0106 44.2 µM 0.0688927883511455 0.464975671929811 no 1545 0.47253747947198 2296 4783639 SGTC_137 0438-0332 85.389 µM 0.068689916207006 0.465060311239372 no 1546 0.472618222473415 2275 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1591 genipin 88.4 µM 0.0682510096072287 0.465243430751137 no 1547 0.472792910903974 2267 442424 A DNA cross-linking agent. SGTC_720 r052-1644 49.9 µM 0.0681806378826971 0.465272791751393 no 1548 0.472820919915808 2231 1422863 YOR257W CDC31 SGTC_3056 9094900 49.47 µM 0.0676036895295044 0.465513517433751 no 1549 0.473050559150659 2230 25236784 SGTC_1773 st048542 73.5835 µM 0.0673535126254602 0.465617905065222 no 1550 0.473150138326736 2216 3237138 SGTC_3091 9116372 49.47 µM 0.0661824576545894 0.466106565261138 no 1551 0.47361628145726 2220 17169793 SGTC_2459 5811157 9.22 µM 0.0661351719634957 0.466126297808656 no 1552 0.473635104479506 2297 2870684 YBR192W RIM2 SGTC_31 0508-1974 57.237 µM 0.0647333944813119 0.466711303945189 no 1553 0.474193136811306 2272 6810525 SGTC_284 0988-0104 32.6 µM 0.0643010455625208 0.466891751412335 no 1554 0.474365260470592 2271 4666532 SGTC_298 1391-0729 10 µM 0.0639879043483123 0.467022449962966 no 1555 0.474489929000983 2264 3237558 SGTC_2254 7938975 95.19 µM 0.0637971837053659 0.46710205448756 no 1556 0.474565860385085 2281 2969277 SGTC_3321 9137793 26.8275 µM 0.0636398963533455 0.467167705344962 no 1557 0.474628481707871 2309 4904192 SGTC_2732 terfenadine 20 µM 0.0636206686927048 0.467175730923833 no 1558 0.474636136921693 2307 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_445 e6 berbamine 66 µM 0.0635349549844627 0.467211507779845 no 1559 0.474670262703603 2228 6610268 A calcium/calmodulin antagonist. SGTC_57 miconazole 162.5 nM 0.0632352704915366 0.4673365980073 no 1560 0.474789579589172 2296 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_503 tyrphostin 8 294 µM 0.0631777941665825 0.467360589362642 no 1561 0.47481246356813 2290 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2961 9083290 32.55 µM 0.0631361256154706 0.467377982424544 no 1562 0.474829053794353 2306 17741490 SGTC_320 4092-0846 5.34 µM 0.0625329395005889 0.467629768079932 no 1563 0.475069215665664 2283 1359356 SGTC_1828 st055811 49 µM 0.0613345247336015 0.468130056068273 no 1564 0.475546397894261 2309 5877589 SGTC_193 1273-0060 1.558 µM 0.0610172013887017 0.468262533739975 no 1565 0.475672754926484 2296 2847393 YHR072W ERG7 SGTC_756 0508-1999 28.3 µM 0.0604653870844418 0.468492916183423 no 1566 0.475892491247369 2231 6753853 SGTC_2308 7584454 197.62 µM 0.0604191161310714 0.468512234784606 no 1567 0.475910916999179 2273 893577 SGTC_651 3253-0966 34.4 µM 0.0603900145526772 0.468524385032297 no 1568 0.475922505688038 2263 781462 SGTC_67 0335-0847 266 µM 0.0601069982879012 0.468642549144106 no 1569 0.476035208107717 2277 4552207 YOR254C SEC63 SGTC_880 0833-0487 87.2 µM 0.0593637212998187 0.468952893075986 no 1570 0.476331204142841 2305 76075 SGTC_2155 5570423 76 µM 0.0589151128751763 0.469140211799959 no 1571 0.476509860313591 2217 797402 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.0576557325242779 0.469666108828634 no 1572 0.477011427665682 2292 16486 A toxic proline analog. SGTC_2778 tioconazole 65.09 nM 0.057582489753447 0.469696695471824 no 1573 0.477040598839886 2289 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2265 7929201 200 µM 0.057529640706994 0.469718765678124 no 1574 0.477061647665873 2308 1265108 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0567740448212204 0.470034319016032 no 1575 0.477362594905921 2306 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2786 7743617 45.45 µM 0.0565851751386122 0.470113198066589 no 1576 0.477437822074007 2229 583674 SGTC_3251 9135047 49.47 µM 0.0558139741872982 0.470435292595184 no 1577 0.477745001253179 2299 17682963 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0557706464563813 0.470453389135593 no 1578 0.477762259635251 2258 6708760 SGTC_3290 9121031 71.43 µM 0.0553319136055743 0.470636636567365 no 1579 0.477937018861047 2264 17014854 SGTC_1048 3161-0300 24.5 µM 0.0506072730087523 0.472610383512835 no 1580 0.479819233615389 2311 2165101 SGTC_2043 5101342 149 µM 0.049701206384906 0.472988976648475 no 1581 0.480180247546668 2277 678451 SGTC_837 0091-0265 12.5 µM 0.0490076035977965 0.473278809872977 no 1582 0.480456618213904 2269 759367 SGTC_2166 5933061 31.504 µM 0.0482913106062197 0.473578139415738 no 1583 0.480742039803792 2268 2877375 SGTC_176 1486-1328 72.834 µM 0.0476941280645452 0.473827705658738 no 1584 0.480980006952385 2273 22310231 SGTC_427 1354-0053 47.3 µM 0.0472703268497564 0.474004821020236 no 1585 0.481148888689675 2259 6813657 SGTC_2322 7413319 38.22 µM 0.0460925611328978 0.47449706073655 no 1586 0.481618237532279 2274 1840400 SGTC_2342 7990637 118.86 µM 0.0459338239295669 0.474563406938528 no 1587 0.481681497511183 2282 2033102 YER133W GLC7 SGTC_1297 1068-0111 14.1 µM 0.0459205868919933 0.474568939556038 no 1588 0.481686772758642 2290 767057 SGTC_59 0330-0160 1.33 µM 0.0450080911539641 0.474950342539074 no 1589 0.482050429841633 2242 4293482 SGTC_221 trifluoperazine 10.304 µM 0.0448371347482208 0.475021801089478 no 1590 0.482118562797656 2306 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_645 0845-0943 5.41 µM 0.0427545179302439 0.47589238379979 no 1591 0.482948610122255 2289 1885106 SGTC_2702 st077768 96.8 µM 0.042494848133153 0.476000940024604 no 1592 0.483052109318287 2289 6484119 SGTC_813 k007-0158 173 µM 0.042403593083276 0.476039090066571 no 1593 0.483088482030547 2309 6523916 SGTC_2942 9052777 62.25 µM 0.042334898678451 0.476067808561115 no 1594 0.483115862545914 2311 6469503 SGTC_390 dec-rvkr-cmk 16.7 µM 0.0408000004321229 0.476709522762184 no 1595 0.483727669507895 2303 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1308 1187-1617 41.4 µM 0.0386736264304518 0.477598622118865 no 1596 0.484575300366661 2332 2882570 SGTC_636 0kpi-0074 126 µM 0.03775258527087 0.477983771321411 no 1597 0.484942474434951 2294 616434 SGTC_2940 9060638 45.86 µM 0.0371300162889035 0.478244120918468 no 1598 0.48519066949309 2284 4027022 SGTC_962 1254-0300 21.5 µM 0.0357138265105018 0.478836385981884 no 1599 0.485755272812332 2319 7340576 SGTC_1006 4099-6547 255 µM 0.0342368310563129 0.479454130370602 no 1600 0.486344148405313 2319 3146833 SGTC_1600 coumarin 106 71.1 µM 0.0328664226344986 0.480027339551885 no 1601 0.486890554588985 2307 100336 A hepatotoxic, DNA x-linker. SGTC_1849 st056239 19.2 µM 0.0326241332109676 0.480128687773857 no 1602 0.48698716227605 2307 5393181 SGTC_1279 0874-0590 65.2 µM 0.0323776843830092 0.48023177716773 no 1603 0.48708542921939 2311 3523074 SGTC_1818 st052136 56.3 µM 0.0320519083990357 0.48036805109033 no 1604 0.487215327611443 2300 674169 SGTC_3310 9130229 44.1445 µM 0.0319776210598183 0.480399126223112 no 1605 0.487244948788018 2331 7761258 SGTC_701 4424-0219 185 µM 0.0314682722556152 0.480612195091809 no 1606 0.487448047339936 2356 2911779 SGTC_1070 indatraline 8.81 µM 0.0307554026258109 0.480910409311549 no 1607 0.487732303563969 2316 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1995 st072814 61.1 µM 0.0305222570943207 0.481007943234088 no 1608 0.487825271527239 2316 5769371 SGTC_1919 st067113 52.3 µM 0.0305208598121318 0.481008527775479 no 1609 0.487825828702598 2307 1268243 SGTC_312 4092-0653 6.84 µM 0.0303341679342697 0.481086629137655 no 1610 0.487900273516244 2307 1148278 SGTC_963 1269-2853 151 µM 0.0280553658764718 0.482040009126574 no 1611 0.488808996458776 2335 3668223 SGTC_2571 chrysanthemic acid 100 µM 0.0280143245722082 0.4820571804913 no 1612 0.488825363137308 2289 2743 An insecticide. SGTC_2969 9091408 28.7 µM 0.0277327470496763 0.482174991247915 no 1613 0.488937652686628 2239 4286311 SGTC_217 ketoconazole 989 nM 0.0258979458006436 0.482942701412064 no 1614 0.489669369256018 2333 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_544 k015-0020 52.4 µM 0.0253358309721999 0.483177912027561 no 1615 0.48989354705697 2329 3008304 SGTC_2389 9091542 195.52 µM 0.025177793584742 0.483244042049346 no 1616 0.489956574746551 2299 3626624 YOL127W RPL25 SGTC_3157 9099274 49.47 µM 0.024914659563073 0.483354150298718 no 1617 0.490061517111862 2356 17217662 SGTC_2370 9071495 200 µM 0.0240756169299898 0.483705255545202 no 1618 0.490396146277661 2258 21791103 SGTC_2416 tofa 880 nM 0.0232779377656417 0.484039063581738 no 1619 0.490714285028917 2311 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1531 st059297 52.4 µM 0.02271088887236 0.484276365649481 no 1620 0.490940445006311 2360 7566702 SGTC_635 k038-0028 24.7 µM 0.0206258702847463 0.485148964145023 no 1621 0.491772051675386 2346 4035102 SGTC_2565 isoliquiritigenin 100 µM 0.0198064258444129 0.485491928502713 no 1622 0.492098895903692 2310 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2025 5147754 141 µM 0.0182494004832507 0.486143624011784 no 1623 0.49271994664974 2363 315777 YLR208W SEC13 SGTC_1896 st058441 89 µM 0.0180190342762988 0.48624004734882 no 1624 0.492811834359594 2335 688759 SGTC_570 0987-0065 62.6 µM 0.016848075986262 0.486730182361028 no 1625 0.493278908119409 2375 3104428 SGTC_1033 k072-0102 21.3 µM 0.0165788534217633 0.486842875320488 no 1626 0.493386297382801 2378 5965931 SGTC_2085 5307070 144.047 µM 0.0165237480696776 0.486865941812601 no 1627 0.493408278226638 2369 2840351 SGTC_1854 st056233 32.9 µM 0.0143218238610802 0.487787678117918 no 1628 0.49428661424653 2389 5393174 SGTC_1323 1348-1351 11.2 µM 0.0142209159804366 0.487829920253958 no 1629 0.494326866567183 2341 6989654 SGTC_2395 5646831 180.19 µM 0.0140339741518946 0.487908178349073 no 1630 0.494401438124413 2367 6808628 SGTC_7 0192-1582 4.227 µM 0.0127448229488352 0.488447858835547 no 1631 0.494915688911061 2382 252616 SGTC_2607 solasodine 47.35 µM 0.0121980000884006 0.488676783058856 no 1632 0.495133822702761 2358 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_950 1165-0508 94.1 µM 0.0117977293197187 0.488844356466869 no 1633 0.495293496142121 2358 6148369 SGTC_3102 9121669 49.47 µM 0.0103428191776407 0.489453471151677 no 1634 0.495873885696053 2360 41905072 SGTC_2800 7887935 81.82 µM 0.00974233329660921 0.489704878650478 no 1635 0.496113432819313 2376 2961002 SGTC_2325 6158266 200 µM 0.00941540258180219 0.489841757588675 no 1636 0.496243853320146 2373 3623240 SGTC_2258 7960471 200 µM 0.00699779941560951 0.490853992692808 no 1637 0.497208304727876 2376 2974708 SGTC_540 1187-0821 17.3 µM 0.0057632716670597 0.491370904756653 no 1638 0.49770079998668 2395 847520 SGTC_3088 9117578 49.47 µM 0.00537628457772458 0.491532944069932 no 1639 0.497855183102934 2399 678341 SGTC_2812 7970281 58.44 µM 0.00468056979910582 0.491824257400619 no 1640 0.498132729628713 2393 2233435 SGTC_2926 9010726 65.15 µM 0.00465174459858674 0.491836327334487 no 1641 0.498144229094751 2389 2994293 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.003881937287907 0.492158670349142 no 1642 0.498451334975573 2395 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2937 9044753 11.33 µM 0.00349198367035989 0.492321958404791 no 1643 0.498606902902649 2401 6465530 YGL099W LSG1 SGTC_907 3448-6986 75.5 µM 0.00321688720972377 0.492437152280679 no 1644 0.498716649894188 2398 590582 SGTC_737 1950-0117 57.9 µM 0.00283363269191095 0.492597637304442 no 1645 0.498869545624895 2402 5393513 SGTC_147 4466-0538 29.23 µM 0.00273938177021254 0.492637104372512 no 1646 0.498907146156536 2389 6742687 YHR072W ERG7 SGTC_2906 7926292 26.41 µM 0.00264983369606937 0.492674602215164 no 1647 0.498942870539732 2389 2966319 SGTC_53 0973-0023 39.979 µM 0.00169478221096425 0.493074529575957 no 1648 0.499323880043643 2403 674768 SGTC_2882 9058044 58.44 µM 0.00155869793923462 0.493131515376792 no 1649 0.499378169741458 2398 18076804 SGTC_2100 5377183 190 µM 0.0013126054665417 0.493234567880856 no 1650 0.49947634633228 2402 2844202 SGTC_3306 9127676 59.7925 µM 0.00103536940471716 0.493350662465499 no 1651 0.499586947442422 2403 41905287 SGTC_856 0433-0016 11.3 µM 0.000992139416396924 0.493368765383446 no 1652 0.499604193703681 2400 3911780 SGTC_2872 9044037 25.97 µM -0.000899679665484022 0.494160993248489 no 1653 0.499641079791041 2408 6465195 SGTC_377 3970-0964 33.1 µM -0.00263215040677873 0.494886511863772 no 1654 0.498949925126884 2407 16481235 SGTC_1219 1469-0211 33.1 µM -0.00294834961710899 0.495018930664395 no 1655 0.49882378038443 2408 6822282 SGTC_2708 st078559 56 µM -0.00318605274430531 0.495118477015237 no 1656 0.498728951003097 2411 17250902 SGTC_76 0433-0009 400.328 µM -0.00320223632217628 0.495125254455582 no 1657 0.498722494722571 2431 2841569 SGTC_18 0111-0177 500 nM -0.00373215597405131 0.49534717764537 no 1658 0.498511088641404 2411 721752 SGTC_2929 9013348 24.6 µM -0.00456956204402401 0.495697874900773 no 1659 0.498177014841984 2420 2995952 SGTC_695 3505-6186 243 µM -0.00523782539155389 0.495977739280414 no 1660 0.497910419548495 2417 1819379 SGTC_1380 2291-0730 164 µM -0.00560135524163077 0.496129984077 no 1661 0.497765394251765 2418 2999191 SGTC_2486 5283202 22.39 µM -0.00725883871749969 0.496824138106627 no 1662 0.497104167759587 2429 1377751 SGTC_2865 9030313 51.95 µM -0.00750122684650014 0.496925651103765 no 1663 0.497007471520209 2416 42562754 SGTC_1305 1181-0477 144 µM -0.00781011226505732 0.497055013686211 no 1664 0.49688424767852 2420 6252086 SGTC_2387 9077560 195.08 µM -0.00798353169434969 0.497127642648497 no 1665 0.496815065493146 2416 5303272 SGTC_1729 st035615 45.989 µM -0.0081644540307482 0.497203413968881 no 1666 0.496742890276352 2465 17385451 SGTC_1445 4239-0156 97.7 µM -0.00858982187089087 0.49738156087194 no 1667 0.496573199015744 2429 4008346 SGTC_2374 9071832 200 µM -0.00873786574928439 0.497443562764975 no 1668 0.496514140269933 2420 17381698 SGTC_329 k048-0121 21.3 µM -0.00937558050504905 0.49771064320229 no 1669 0.496259739329069 2437 6832902 SGTC_1255 0566-0045 221 µM -0.0110870626079639 0.498427431401411 no 1670 0.49557699257527 2448 2788469 SGTC_883 0850-0245 24.6 µM -0.0114082363721421 0.49856194326769 no 1671 0.495448870886503 2502 6823229 YPR165W RHO1 SGTC_2069 5228469 200 µM -0.0124692706876089 0.499006319702915 no 1672 0.495025609622561 2438 2835210 SGTC_2930 9013230 14.89 µM -0.0126362739993175 0.499076263218752 no 1673 0.494958990189519 2432 2995857 SGTC_896 0964-0007 44.5 µM -0.0131992961747605 0.499312065628248 no 1674 0.494734395581637 2414 6756758 SGTC_3256 9138902 49.47 µM -0.0135750438489169 0.499469434714124 no 1675 0.494584507380343 2429 17228773 SGTC_1895 st058434 18.3 µM -0.0137044680807873 0.499523639655655 no 1676 0.494532879384913 2430 5393175 SGTC_90 0870-0863 4.608 µM -0.0140660861307912 0.499675091131131 no 1677 0.494388628562712 2427 1738164 SGTC_1655 st012546 55.1 µM -0.014562080942526 0.499882821834881 no 1678 0.494190775533866 2464 720985 YLR208W SEC13 SGTC_1678 st019265 80.2 µM -0.0151216491927247 0.499882821834881 no 1679 0.493967564688907 2433 5367020 SGTC_2232 chlorophetanol 41.5365 µM -0.0152206108735241 0.499841375067172 no 1680 0.493928089233473 2428 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_3080 9117754 49.47 µM -0.0166681754960071 0.499235111796201 no 1681 0.493350667954104 2424 9550191 SGTC_993 3909-8757 62.7 µM -0.0173182538982429 0.498962849030521 no 1682 0.493091361641001 2446 4288324 YLR208W SEC13 SGTC_2098 5376439 882.5 nM -0.0178260303935853 0.498750184806885 no 1683 0.492888819403119 2470 2844116 SGTC_1288 0973-0013 65.5 µM -0.0207088843445002 0.497542811921903 no 1684 0.491738940929317 2470 4315430 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.021169391049935 0.49734994813619 no 1685 0.491555265606139 2510 61125 An anti-inflammatory. SGTC_2744 captopril 92.04 µM -0.0216881981893487 0.497132668420041 no 1686 0.491348339020272 2452 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_689 0833-0039 98 µM -0.022419302382176 0.496826478812005 no 1687 0.49105674157331 2456 5374726 SGTC_2337 9009472 200 µM -0.023292601486711 0.496460739823546 no 1688 0.49070843663632 2455 5742383 SGTC_350 k064-0020 19.8 µM -0.0240133085463375 0.496158908841774 no 1689 0.490420996541863 2452 2790705 SGTC_15 0266-0086 27.098 µM -0.0243486201131741 0.496018481624532 no 1690 0.490287265684575 2431 1712902 YIL048W NEO1 SGTC_1648 st011736 69.8 µM -0.0243875300954827 0.496002186302574 no 1691 0.490271747455574 2459 2855514 SGTC_87 0100-0052 35.5 µM -0.0250000161806271 0.495745680838509 no 1692 0.490027475351643 2451 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2842 9000675 19.48 µM -0.0269670243747596 0.494921922139634 no 1693 0.489243017598939 2477 2989072 SGTC_1265 0819-1001 68.8 µM -0.0288840957463617 0.494119097170957 no 1694 0.488478515043061 2458 3106768 SGTC_2016 5121758 140 µM -0.0290179647022559 0.494063036813223 no 1695 0.48842513143331 2454 2795203 SGTC_929 2805-0021 398 µM -0.02927701767996 0.493954553425141 no 1696 0.488321828139263 2526 3098024 SGTC_1226 3909-7979 35.4 µM -0.0297387977267724 0.49376117531429 no 1697 0.48813768474179 2494 6615510 SGTC_1135 dihydrocapsaicin 536.708 nM -0.0308121108827845 0.493311713236887 no 1698 0.487709690959456 2449 107982 A Capsaicinoid. SGTC_1709 st033179 39.1045 µM -0.0312065988301922 0.493146519031014 no 1699 0.487552388686697 2451 573381 SGTC_2363 9053361 176 µM -0.0312399208012667 0.493132565308205 no 1700 0.487539101621874 2476 6469797 YMR079W SEC14 SGTC_1174 0739-0097 51.1 µM -0.0316040233396494 0.492980096310648 no 1701 0.487393917416518 2486 728447 SGTC_1774 st048371 48.465 µM -0.031611099595204 0.492977133118128 no 1702 0.487391095808789 2460 4242727 SGTC_212 3807-4682 38.772 µM -0.0318211678041417 0.492889166920977 no 1703 0.487307332858352 2500 3125501 YBL034C STU1 SGTC_444 curcumin 90.4 µM -0.0319059028964414 0.492853684144392 no 1704 0.487273545603609 2479 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_700 3453-2283 142 µM -0.0321820242706357 0.492738058853911 no 1705 0.487163445653956 2491 565664 SGTC_1387 3342-1166 1.8 µM -0.0327036581328738 0.492519627357665 no 1706 0.486955453342485 2512 3418228 SGTC_589 1227-0070 34.1 µM -0.0330611343511651 0.492369937321608 no 1707 0.486812918044649 2499 2841384 SGTC_668 1682-0499 62.6 µM -0.0331027004541418 0.492352531949302 no 1708 0.4867963446403 2493 682214 SGTC_2634 4'-methoxyflavone 100 µM -0.0331253547152264 0.492343045719766 no 1709 0.486787311851482 2478 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_421 streptovitacin 30 mM -0.0346727642606636 0.491695095057322 no 1710 0.486170339417866 2610 91467 include heat shock SGTC_2792 7535235 81.82 µM -0.0350080971897744 0.491554683092767 no 1711 0.486036642104306 2512 1281891 SGTC_1157 4092-0394 27.6 µM -0.0354407823890512 0.491373508939459 no 1712 0.485864132740218 2564 3659885 SGTC_3211 9128781 49.47 µM -0.0365575880236881 0.490905887866598 no 1713 0.485418880380657 2561 17194361 SGTC_194 1486-1323 56.904 µM -0.0375829104867196 0.490476582979351 no 1714 0.485010116875609 2494 5178754 SGTC_2539 epi(13)torulosol 80 µM -0.0379095339735475 0.490339827263028 no 1715 0.484879905751495 2513 6708597 SGTC_517 1365-0151 113 µM -0.0383972227918256 0.490135636369214 no 1716 0.484685487620959 2589 768657 SGTC_2357 9067248 200 µM -0.0385923514639451 0.49005393848155 no 1717 0.484607700199604 2500 9150235 SGTC_873 0591-4978 488 µM -0.0388490364930249 0.489946468367953 no 1718 0.484505374425912 2479 3305145 SGTC_1510 1123-0200 71.5 µM -0.0394743203385079 0.489684674612139 no 1719 0.48425611347797 2496 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2095 5432005 200 µM -0.0398393843716359 0.489531831699579 no 1720 0.484110588477018 2493 783734 SGTC_2061 5245884 80.95 µM -0.0399704285226779 0.489476967260875 no 1721 0.484058351032661 2486 573863 SGTC_2033 5192550 145 µM -0.0404685854184387 0.489268405039909 no 1722 0.483859775860155 2487 182073 SGTC_1413 3910-0535 34.4 µM -0.0405529834896898 0.489233070579408 no 1723 0.48382613351811 2523 2876951 SGTC_1424 4048-1941 275 µM -0.0419408365885254 0.488652038340379 no 1724 0.483272931066331 2536 X1424 SGTC_1221 2958-7315 257 µM -0.0444347648124329 0.487608003086351 no 1725 0.482278925346121 2529 4562705 SGTC_2165 5727197 32.143 µM -0.0444652372348172 0.487595246901301 no 1726 0.482266780612172 2740 1361712 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0446143029246212 0.487532846087895 no 1727 0.482207370963409 2469 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2924 9010168 62.78 µM -0.0446159237559304 0.487532167588754 no 1728 0.4822067249885 2536 2993929 SGTC_2066 5222451 176 µM -0.0456356564429021 0.4871053026697 no 1729 0.481800324517417 2490 2281147 SGTC_2522 biochanin a 4.94 µM -0.0463407733291772 0.486810146020499 no 1730 0.481519320891358 2512 5280373 A possible chelator. SGTC_2208 7283366 200 µM -0.046867980088167 0.486589465930105 no 1731 0.481309224112781 2494 898663 SGTC_1751 st044839 27.194 µM -0.0476147752688253 0.48627687677731 no 1732 0.481011628212166 2483 5291326 SGTC_1916 st067606 49.2 µM -0.0477761602906564 0.486209326281438 no 1733 0.480947318093403 2548 19590279 SGTC_1613 st002381 52.1 µM -0.0483299369339667 0.485977536497089 no 1734 0.480726648100476 2511 551167 SGTC_62 0180-0423 3.232 µM -0.0491285118204985 0.485643291865496 no 1735 0.48040844084448 2521 30102 YGL099W LSG1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0491793134034546 0.485622029130905 no 1736 0.480388198413847 2512 6728940 SGTC_1631 benzylvanillin 81.9 µM -0.0499619961978836 0.485294446578668 no 1737 0.480076336559676 2572 75506 SGTC_2639 lactacystin 53 µM -0.0501104592029733 0.485232310270917 no 1738 0.480017182486074 2520 3870 A proteasome inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0501966146869709 0.485196251730482 no 1739 0.479982854621755 2471 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1693 xanthone 101.9 µM -0.0502462870860894 0.485175462462163 no 1740 0.479963063176258 2535 7020 An insecticide. SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0506106957552749 0.485022948624448 no 1741 0.479817869884646 2536 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2243 6634756 200 µM -0.051137403340352 0.484802512644559 no 1742 0.479608015706796 2550 885676 SGTC_474 dl-dihydrosphingosine 5 µM -0.0527050497302374 0.484146454018431 no 1743 0.478983457758595 2623 3058739 A sphingolipid protein kinase C inhibitor. SGTC_897 1000-0139 31.4 µM -0.0528683934928851 0.484078097236751 no 1744 0.478918383751036 2492 6151020 SGTC_2799 7812892 81.82 µM -0.0540363075504649 0.483589357426334 no 1745 0.478453118621997 2545 20205235 SGTC_1302 1159-0335 255 µM -0.0544827036257524 0.483402559458026 no 1746 0.478275294313729 2510 649284 SGTC_1706 st031321 9.9705 µM -0.0551373618006997 0.48312861916733 no 1747 0.478014515495514 2514 6103185 SGTC_1853 st056710 91.2 µM -0.0561022631121819 0.482724872867584 no 1748 0.477630170538625 2614 269167 SGTC_3353 9151644 39.2805 µM -0.0579492558443206 0.48195208039858 no 1749 0.476894524261308 2568 4909158 SGTC_1427 4048-4900 550 nM -0.0583684078275299 0.481776714114634 no 1750 0.476727589377808 2546 24132586 SGTC_525 k781-2675 26.7 µM -0.0588952965213638 0.481556277572194 no 1751 0.476517752191376 2514 3651118 YDL195W SEC31 SGTC_2484 5809818 12.04 µM -0.0595726071300087 0.481272916701196 no 1752 0.476248017976057 2549 2870548 SGTC_1114 scopoletin 1.73284 µM -0.0596420522308094 0.481243864057654 no 1753 0.476220362563161 2507 5280460 A coumarin with genotoxic properties. SGTC_308 4092-1169 104 µM -0.0602486497319947 0.480990095750441 no 1754 0.475978799588236 2512 2268590 YDL196W YDL196W SGTC_2863 9028737 58.44 µM -0.0606412977256317 0.48082583670042 no 1755 0.475822441598691 2617 6460917 SGTC_707 0865-0008 204 µM -0.0620009188911357 0.480257082653901 no 1756 0.475281050120873 2532 723043 SGTC_2181 6316240 54.2555 µM -0.0624535366982755 0.480067753324403 no 1757 0.475100831005017 2561 12779990 SGTC_1248 0469-0687 58.6 µM -0.0624550047585603 0.480067139244347 no 1758 0.475100246474802 2568 4017482 SGTC_102 gallobenzophenone 83.616 µM -0.0628810753547423 0.479888918693946 no 1759 0.474930602348376 2520 70837 SGTC_1333 1482-0047 286 µM -0.0637451860422585 0.479527483269838 no 1760 0.474586562313623 2517 3811116 SGTC_692 k241-0027 77.8 µM -0.0639403963618402 0.479445834100697 no 1761 0.474508843212916 2575 3600480 SGTC_409 arachidonic acid 100 µM -0.0640741473646062 0.479389891560807 no 1762 0.474455593474953 2519 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_206 4546-0025 72.014 µM -0.0647681845245878 0.479099610923953 no 1763 0.474179286657088 2542 6620745 YIL048W NEO1 SGTC_1088 bifonazole 369 nM -0.0654366761588278 0.478820025167362 no 1764 0.473913161645362 2496 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1409 3909-8004 61.9 µM -0.0672255358578469 0.478071915319228 no 1765 0.473201078214716 2550 2119279 SGTC_2365 9042475 200 µM -0.0673065408170774 0.478038040458951 no 1766 0.473168834940037 2571 6464479 SGTC_542 3381-0244 89.3 µM -0.0678777204002174 0.477799187643043 no 1767 0.472941487192719 2550 1112843 SGTC_157 1348-1695 65.819 µM -0.0684531994031766 0.477558544983583 no 1768 0.472712437052908 2532 5380510 SGTC_3244 9134489 49.47 µM -0.0690839810222601 0.477294786350437 no 1769 0.472461385927217 2593 16584271 SGTC_1207 2099-0101 141 µM -0.0703276083245818 0.476774798162799 no 1770 0.471966454319909 2562 5837381 SGTC_2022 5136654 200 µM -0.0704294742969737 0.47673220747818 no 1771 0.471925916196508 2617 1713771 SGTC_1175 0741-0056 27.6 µM -0.0708631876741716 0.476550872675417 no 1772 0.47175332083541 2593 765927 SGTC_2012 4023501 200 µM -0.0711379349787203 0.476436003818918 no 1773 0.471643988443786 2570 3477460 SGTC_54 0159-0055 9 µM -0.0714937567061403 0.476287241540455 no 1774 0.471502396635802 2524 3319099 SGTC_982 1491-0518 27.5 µM -0.0722088742320981 0.475988274557315 no 1775 0.471217841497939 2593 3091256 SGTC_3260 9137109 49.47 µM -0.0725510884024292 0.475845210903988 no 1776 0.471081674943533 2497 17478346 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0742586486289011 0.475131407162185 no 1777 0.470402289879692 2544 5106787 A p450 inhibitor. SGTC_2369 9071472 200 µM -0.0745028131658012 0.475029346624823 no 1778 0.470305151403764 2635 17296037 SGTC_2031 5180455 200 µM -0.0746415416616564 0.474971358978922 no 1779 0.470249960413674 2540 29949 SGTC_2349 9023730 187.07 µM -0.0747675544853347 0.474918686864156 no 1780 0.470199828652721 2586 4126287 SGTC_1353 1498-1206 8.11 µM -0.0758219900300023 0.474477960497789 no 1781 0.469780360484247 2526 6756808 SGTC_2037 5169046 200 µM -0.0760285411476941 0.474391631196211 no 1782 0.469698195677623 2618 5718022 SGTC_1638 st008370 60.6 µM -0.0774663521273298 0.473790722853569 no 1783 0.469126278961945 2527 24207134 SGTC_2079 5212404 121 µM -0.0778749844738648 0.473619952822486 no 1784 0.468963749232239 2548 758462 SGTC_1990 st072050 59.8 µM -0.0798125239290251 0.472810309398728 no 1785 0.468193181723639 2524 17233948 SGTC_1501 4491-0275 38.4 µM -0.0810524307944599 0.472292245805601 no 1786 0.467700127941968 2545 5104718 SGTC_838 0109-0203 71.4 µM -0.081555867108576 0.472081911057508 no 1787 0.467499948636593 2555 759422 SGTC_1494 4358-1428 177 µM -0.0816753719753385 0.472031983289482 no 1788 0.467452431614433 2551 1564571 SGTC_1571 st070080 73.4 µM -0.0828178848563048 0.471554676758993 no 1789 0.466998173960879 2632 4315245 SGTC_146 3448-8650 53.125 µM -0.082906153049404 0.471517802730358 no 1790 0.46696308073075 2595 2891488 YIL048W NEO1 SGTC_2390 9097792 176.6 µM -0.0843656104765145 0.470908150168902 no 1791 0.466382874321254 2575 4497149 SGTC_1322 1348-1070 12 µM -0.0844264689773969 0.470882729492883 no 1792 0.466358681604366 2540 6758089 SGTC_500 h-89 112 µM -0.0856442290962416 0.470374094562841 no 1793 0.46587461893414 2687 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_307 1501-1223 22.3 µM -0.0879694994489991 0.469403008901554 no 1794 0.464950459024194 2597 2830329 SGTC_362 0310-0100 9.03 µM -0.0886461559405249 0.46912045572298 no 1795 0.464681562655804 2643 790235 SGTC_2171 5739187 198.077 µM -0.0887197218948049 0.469089737534382 no 1796 0.46465232926795 2548 2262761 SGTC_2919 7978188 46.38 µM -0.0891448588052523 0.468912221040998 no 1797 0.464483393555564 2586 2980291 SGTC_815 1582-0027 36.9 µM -0.0904068640875378 0.468385305561542 no 1798 0.463981951139675 2628 3128206 SGTC_628 1636-0253 16 µM -0.0908853299765903 0.468185549761003 no 1799 0.4637918534643 2619 4456143 SGTC_1177 0983-0204 23.6 µM -0.0911106030201146 0.468091502781598 no 1800 0.463702353847564 2601 766818 SGTC_1382 3002-2117 298 µM -0.092128089844815 0.467666744693774 no 1801 0.46329813544179 2593 1497314 SGTC_4 0960-0234 25.671 µM -0.0922465836738858 0.467617280872258 no 1802 0.46325106368877 2608 6821112 SGTC_852 0418-0143 439 µM -0.0929269962229545 0.467333260552292 no 1803 0.462980779327452 2583 5369229 SGTC_130 0136-0219 337.655 µM -0.0930606192518602 0.467277485083061 no 1804 0.462927701453224 2540 234244 SGTC_1247 0448-0043 5.84 µM -0.0934734969720298 0.467105150226763 no 1805 0.462763701923589 2652 3089013 YGL099W LSG1 SGTC_1757 st041620 31.8375 µM -0.0938994367916707 0.466927369721929 no 1806 0.46259452061866 2631 5289815 SGTC_855 0428-0020 25 µM -0.0943312688517111 0.466747136625125 no 1807 0.462423005850943 2602 6812414 SGTC_1731 st035964 63 µM -0.0948600998272964 0.466526428528366 no 1808 0.462212974639111 2637 6739575 SGTC_512 prima-1 270 µM -0.0948716821557557 0.466521594747811 no 1809 0.462208374703866 2721 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2064 5220758 200 µM -0.0954313668454882 0.466288021277066 no 1810 0.461986101312098 2699 788518 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0955459313490249 0.466240211448715 no 1811 0.461940604582826 2578 140250 A respiratory chain inhibitor. SGTC_810 3825-7150 143 µM -0.0960018617140749 0.466049948339249 no 1812 0.461759546980014 2584 22330411 YGL099W LSG1 SGTC_1986 st071812 45 µM -0.0963063888710246 0.465922871226354 no 1813 0.461638618545101 2584 11838594 SGTC_1291 0993-0025 5.79 µM -0.096497485882901 0.465843129515479 no 1814 0.461562735292197 2656 4353356 SGTC_1023 4482-3888 16 µM -0.0965436199283726 0.465823878725356 no 1815 0.461544416003186 2674 3303168 SGTC_2126 5251174 33.877 µM -0.0968692965976172 0.465687982814339 no 1816 0.461415095936316 2619 790722 SGTC_3072 9116419 49.47 µM -0.0971554045460694 0.465568601142397 no 1817 0.461301491228544 2634 17170162 SGTC_780 0109-0199 192 µM -0.0996603981556581 0.464523498658668 no 1818 0.46030697082666 2725 610414 SGTC_886 0866-0150 153 µM -0.100202277348909 0.464297454462228 no 1819 0.460091869026655 2702 271463 SGTC_1852 st056254 31.4 µM -0.101194446500825 0.463883602315508 no 1820 0.459698052569907 2636 442583 SGTC_1936 st074407 74.3 µM -0.101340425035205 0.463822715249501 no 1821 0.459640113409283 2585 809813 SGTC_1612 st002233 45.4 µM -0.102188847667417 0.463468858362629 no 1822 0.459303389843155 2589 1035021 SGTC_735 3076-0345 636 µM -0.102577834347011 0.463306630922442 no 1823 0.459149017825765 2658 2888990 SGTC_1056 3448-1962 115 µM -0.103455421572612 0.462940654392461 no 1824 0.458800764008102 2676 715507 SGTC_3128 9127691 49.47 µM -0.10362959205189 0.462868024526409 no 1825 0.458731651514042 2750 41316314 SGTC_2044 5102272 200 µM -0.105637247571757 0.462030913208172 no 1826 0.457935085395974 2664 592666 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.106416130420957 0.461706195569111 no 1827 0.45762609776069 2571 756377 SGTC_2354 9060492 162 µM -0.10747995232256 0.461262727616273 no 1828 0.457204114456981 2689 6471895 SGTC_2197 6588183 93.1375 µM -0.107530986274459 0.461241454658059 no 1829 0.45718387216884 2604 884136 SGTC_551 k048-0028 34.9 µM -0.107798874134105 0.461129790283062 no 1830 0.457077617998847 2689 6836383 SGTC_2381 9035592 200 µM -0.107945225375021 0.46106878761854 no 1831 0.457019571013862 2629 4749657 SGTC_192 3455-0609 60.9 µM -0.108998875653617 0.46062962834561 no 1832 0.456601691060541 2706 3769639 SGTC_863 0466-0191 129 µM -0.109707215035996 0.460334420902208 no 1833 0.456320789094164 2602 765160 YPR165W RHO1 SGTC_1250 0485-0349 40.2 µM -0.109822781143281 0.460286259654071 no 1834 0.45627496179283 2637 6842794 YDL195W SEC31 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.109890139377397 0.460258188919064 no 1835 0.456248251408937 2577 1241132 A phosphatase inhibitor. SGTC_2817 7995342 71.43 µM -0.111010791286717 0.459791199862508 no 1836 0.455803894708477 2601 18879975 SGTC_3047 9092122 49.47 µM -0.11189262277889 0.45942376909264 no 1837 0.45545427302026 2656 17173831 SGTC_1885 st057546 99.9 µM -0.113843881598423 0.458610866040629 no 1838 0.454680776105943 2775 702008 SGTC_1878 temozolomide 1 mM -0.11533668095041 0.457989075891304 no 1839 0.454089132577937 2594 5394 DNA alkylating agent. SGTC_820 1582-0060 59.9 µM -0.115454678705815 0.457939931090252 no 1840 0.45404237066773 2643 3848840 SGTC_1203 3992-3522 103 µM -0.115472259011898 0.457932609136122 no 1841 0.454035403736373 2849 5322312 SGTC_2434 5670830 169.91 µM -0.115744351139467 0.457819288353233 no 1842 0.453927577658726 2705 1549830 SGTC_2848 9016370 25.97 µM -0.115794920573736 0.457798227600037 no 1843 0.45390753811535 2614 7894410 SGTC_2213 7173844 200 µM -0.116255815449716 0.457606283260261 no 1844 0.453724901129784 2628 892728 SGTC_2188 6126565 140.678 µM -0.116958507278171 0.457313659174483 no 1845 0.453446467070375 2638 874518 SGTC_1104 tacrolimus 29.8 µM -0.117497261304222 0.457089319868412 no 1846 0.453233007087603 2601 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.118775233605231 0.456557221968273 no 1847 0.452726715241378 2635 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1520 flindersine 88 µM -0.120905779127344 0.455670319406679 no 1848 0.45188283233667 2905 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1653 st012112 65 µM -0.120993797807288 0.455633683749363 no 1849 0.451847973868218 2743 720429 SGTC_1199 1638-0010 4.46 µM -0.121686920299237 0.455345201399448 no 1850 0.451573486169829 2617 3111136 SGTC_462 ag-879 158 µM -0.12262739256505 0.454953808047801 no 1851 0.45120108100863 2700 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_989 1501-0895 10.3 µM -0.124530901493199 0.454161764992809 no 1852 0.450447467475154 2622 2830112 SGTC_872 0588-0139 234 µM -0.126877437724204 0.453185631040224 no 1853 0.449518702195796 2648 2047100 SGTC_3225 9130819 49.47 µM -0.126945490784997 0.453157325886749 no 1854 0.449491770714428 2645 4547121 SGTC_464 bw-b 70c 158 µM -0.12715370002912 0.453070727371972 no 1855 0.449409374934546 2765 5353454 SGTC_2401 5128683 200 µM -0.127314579770875 0.453003815700722 no 1856 0.449345710610551 2672 708373 SGTC_381 3461-2219 42.7 µM -0.128042156690141 0.452701225070563 no 1857 0.449057805690577 2697 2883159 SGTC_270 tamoxifen 5.46 µM -0.12912268054478 0.452251898721439 no 1858 0.448630287878633 2750 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2329 6138490 200 µM -0.130752314420578 0.451574345630189 no 1859 0.447985623309365 2911 720019 SGTC_1007 4101-0031 70 µM -0.134392987808376 0.450061174779389 no 1860 0.446545913126394 2738 1146276 SGTC_2143 5623677 140.463 µM -0.135945229270935 0.449416237005963 no 1861 0.445932289781895 2623 5375313 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.136082175018553 0.44935934407366 no 1862 0.445878159355011 2638 803109 SGTC_207 4185-0010 4.486 µM -0.136311918036442 0.44926390165286 no 1863 0.445787351297786 2657 3761753 SGTC_1634 st006576 41 µM -0.138715637558513 0.448265498589912 no 1864 0.444837430292736 2730 3915356 SGTC_3226 9131256 49.47 µM -0.139396539249363 0.44798274019787 no 1865 0.444568403470449 2633 17178073 SGTC_1695 st026914 34.495 µM -0.140557966524925 0.447500494764118 no 1866 0.444109578167616 2638 3289191 SGTC_1952 st077036 64.1 µM -0.143289226568642 0.446366733665096 no 1867 0.443030881993335 2632 2937007 SGTC_1258 0671-0043 57.1 µM -0.143713031967214 0.446190848757178 no 1868 0.442863540004355 2718 4298767 SGTC_2763 lisinopril 49.32 µM -0.145353358867648 0.445510191251796 no 1869 0.442215943861824 2648 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2520 obtusaquinone 4.71 µM -0.146080043754361 0.445208702857607 no 1870 0.4419291000933 2811 5967872 SGTC_2415 st077333 57.7 µM -0.14667841773938 0.444960472112812 no 1871 0.441692927240492 2710 2766255 SGTC_333 3486-0131 40.1 µM -0.146752309065151 0.444929820372146 no 1872 0.441663764432143 2811 6744690 SGTC_3195 9113082 49.47 µM -0.147387047770272 0.444666530433729 no 1873 0.441413264128812 2652 17018038 SGTC_3331 9141060 1.957 µM -0.147499840049383 0.444619746689974 no 1874 0.441368752985434 2677 4906567 YPR165W RHO1 SGTC_2558 carylophyllene oxide 100 µM -0.149753837266627 0.443685001083164 no 1875 0.440479415531947 2661 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2041 5107442 45.335 µM -0.149939028135659 0.443608215219654 no 1876 0.44040635987998 2750 793005 SGTC_3292 9120825 59.784 µM -0.150317239319789 0.443451403742511 no 1877 0.440257166254754 2697 24824900 SGTC_1791 st048313 56.1 µM -0.150468815959751 0.443388560499741 no 1878 0.440197375932906 2771 1204976 SGTC_259 usnic acid 108.925 µM -0.152254970951497 0.442648133399724 no 1879 0.439492919375729 2852 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3259 9138485 49.47 µM -0.152650807942917 0.442484071390765 no 1880 0.439336827776832 2889 17646153 SGTC_3343 9148379 18.9835 µM -0.156887365429243 0.440728774591052 no 1881 0.43766680873673 2817 1955036 SGTC_1369 1866-0067 208 µM -0.157589466805131 0.440437990408515 no 1882 0.437390152063474 2725 3531355 SGTC_3230 9131665 49.47 µM -0.157790670778862 0.440354665147022 no 1883 0.437310875101075 2678 15943720 SGTC_2131 toluylene red 5.2905 µM -0.157924944851597 0.440299059254193 no 1884 0.437257970783545 2724 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1263 0774-1208 64.8 µM -0.15845822997307 0.44007822560793 no 1885 0.43704786620826 2774 906585 SGTC_3116 9124943 49.47 µM -0.158535256217521 0.440046330538994 no 1886 0.437017520743999 2697 41905195 YPL160W CDC60 SGTC_954 1189-0853 2.85 µM -0.158624764895854 0.440009267225851 no 1887 0.436982258132377 2640 2828194 SGTC_40 0327-0103 19.753 µM -0.158810573720794 0.439932330100506 no 1888 0.436909058958259 2742 409036 SGTC_2296 7971656 126.45 µM -0.159778887803458 0.439531420893615 no 1889 0.436527627746967 2758 666570 SGTC_3246 9135460 32.98 µM -0.159884066511587 0.439487877682626 no 1890 0.436486200065105 2739 41446951 SGTC_697 0508-1955 564 µM -0.159931530573725 0.439468228149963 no 1891 0.436467505197009 2758 6243113 SGTC_1609 st001574 46.4 µM -0.160542612648092 0.439215261091995 no 1892 0.4362268284414 2695 3960012 SGTC_2104 5389443 200 µM -0.161252398149327 0.438921465360706 no 1893 0.435947306649729 2846 2244536 SGTC_1012 4112-3522 18 µM -0.161932874542411 0.438639832899444 no 1894 0.435679357160723 2704 3112398 SGTC_3174 9107204 49.47 µM -0.164067050989657 0.437756751852054 no 1895 0.434839179894846 2809 3938802 SGTC_1515 3460-0031 42.1 µM -0.164547200003988 0.437558118001724 no 1896 0.434650196426163 2725 2876596 SGTC_2261 9010538 184.68 µM -0.164648577052662 0.437516181128582 no 1897 0.434610296999477 2824 6457250 SGTC_1723 st034307 2.5525 µM -0.164946173639878 0.437393077731263 no 1898 0.434493174403983 2772 867466 SGTC_610 4215-0184 155 µM -0.165134050625379 0.437315363914375 no 1899 0.434419236192661 2761 5605015 SGTC_471 1-acyl-paf 4 µM -0.165362398069791 0.437220913071093 no 1900 0.434329374088003 2677 16759367 SGTC_2375 9072683 200 µM -0.165364781680178 0.437219927162513 no 1901 0.434328436078111 2692 16798029 SGTC_903 1134-0042 114 µM -0.165401553757104 0.437204717550831 no 1902 0.434313965399336 2704 701009 SGTC_1685 st024049 53.0905 µM -0.165572709802075 0.437133925464084 no 1903 0.434246612620995 2769 1941139 SGTC_1043 0916-0009 19.3 µM -0.166045391814606 0.436938429269891 no 1904 0.434060614230292 2708 3101130 SGTC_3351 9150312 21.596 µM -0.166140542686163 0.436899077753603 no 1905 0.434023174524889 2668 4904905 SGTC_3031 9088762 49.47 µM -0.167132778393239 0.436488756416071 no 1906 0.433632787653408 2680 205253 SGTC_745 0469-0705 296 µM -0.167314505616844 0.436413613762044 no 1907 0.433561295594191 2840 3486736 SGTC_2462 5162487 171.77 µM -0.168061629896495 0.43610470839542 no 1908 0.433267397425266 2675 2259986 SGTC_431 k089-0097 107 µM -0.168310984958831 0.436001618928829 no 1909 0.433169316198376 2716 5499420 SGTC_142 0335-0849 62.6745 µM -0.169568673621038 0.435481726159876 no 1910 0.432674680271785 2723 3889043 YPR107C YTH1 SGTC_2493 resveratrol 26.09 µM -0.169668608979534 0.435440420491079 no 1911 0.432635381243752 2682 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_454 lyso-paf C-16 6.67 µM -0.16970536545941 0.435425228337842 no 1912 0.432620927128548 2772 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_588 3970-1144 52.9 µM -0.174620575556091 0.433394545674699 no 1913 0.430688890016979 2854 1888707 SGTC_1187 1391-0724 117 µM -0.176036490581659 0.432809894497742 no 1914 0.430132637365132 2756 6997986 SGTC_2597 laccaic acid a 100 µM -0.177749161193395 0.432102905398797 no 1915 0.42945998745257 2837 5491415 A textile dye. SGTC_1277 0873-0036 22 µM -0.178557555216104 0.431769276350308 no 1916 0.429142562404169 2786 5965735 SGTC_1286 0929-0070 131 µM -0.179676299330879 0.431307644279283 no 1917 0.428703350502415 2842 1420408 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.179817247520801 0.431249490878526 no 1918 0.428648021380312 2848 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2766 oltipraz 83.91 µM -0.180508731214369 0.43096421526068 no 1919 0.428376600232454 2850 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_408 cantharidin 100 µM -0.18242696400119 0.430173026154613 no 1920 0.427623833311235 2781 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_165 k038-0023 64.381 µM -0.183220266882033 0.429845904336596 no 1921 0.427312596430688 2752 46368543 SGTC_214 4373-3496 70 µM -0.183395977752459 0.429773455717941 no 1922 0.427243665817393 2758 3779166 SGTC_739 1486-1183 203 µM -0.184451481350159 0.429338303254954 no 1923 0.426829643148292 2787 4346692 SGTC_1243 0416-0003 5.65 µM -0.185981634497249 0.428707619599892 no 1924 0.426229581803425 2796 2141977 SGTC_3163 9099914 49.47 µM -0.186223982035111 0.428607747801223 no 1925 0.426134558977122 2798 16268368 SGTC_2681 menadione 3.18 µM -0.186416795131677 0.428528292488284 no 1926 0.426058961332279 2799 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1815 st051655 58.2 µM -0.186463311563449 0.428509124215481 no 1927 0.426040723700463 2778 5984156 SGTC_1150 3909-7983 10.9 µM -0.186997813252675 0.428288881382742 no 1928 0.425831173738117 2760 23965914 SGTC_3341 9147222 25.867 µM -0.187029082676005 0.428275997425149 no 1929 0.425818915291961 2856 1939759 SGTC_2397 5161689 200 µM -0.187239699871309 0.428189218699409 no 1930 0.425736349614233 2917 2259942 SGTC_1428 4049-0204 61.7 µM -0.187352827059131 0.428142609345794 no 1931 0.425692003093174 2833 X1428 SGTC_478 N-arachidonylglycine 10 µM -0.187550288991631 0.42806125576994 no 1932 0.425614599110047 2728 5283389 SGTC_1370 2001-0092 44.6 µM -0.188670133352899 0.42759994203284 no 1933 0.425175680638375 2896 790957 SGTC_2989 9073649 71.4286 µM -0.188856833235474 0.427523041648968 no 1934 0.425102513377824 2713 21367202 SGTC_999 SEC7.066 22.7 µM -0.188878626650586 0.427514065272181 no 1935 0.425093972755967 2761 740511 YDR170C SEC7 SGTC_68 0986-0284 82.829 µM -0.189911310803127 0.427088761444621 no 1936 0.424689314514851 2951 423278 YIL048W NEO1 SGTC_1128 3448-9350 235 µM -0.190882161037586 0.426689000755939 no 1937 0.424308958312465 2860 619386 SGTC_94 0334-0113 514.748 µM -0.191019326018296 0.426632527284637 no 1938 0.424255225985467 2756 6795178 SGTC_204 PMA1.184 62.41 µM -0.191171324117007 0.426569948489073 no 1939 0.424195684651106 2703 2252213 YGL008C PMA1 SGTC_3030 9087619 49.47 µM -0.192020481439059 0.426220377889028 no 1940 0.423863081043031 2780 25236973 SGTC_185 k048-0037 25.491 µM -0.193161498997434 0.425750749184139 no 1941 0.423416245100575 2824 6827589 SGTC_2988 9073640 71.4286 µM -0.193642498695634 0.425552807174817 no 1942 0.423227909414733 2939 9102229 SGTC_1769 st044406 64.4 µM -0.193804605803024 0.425486100740901 no 1943 0.423164440241197 2752 670903 SGTC_2321 7390090 138.78 µM -0.193856638121595 0.425464690099549 no 1944 0.423144068649873 2837 649046 SGTC_1324 1418-0026 34.4 µM -0.19392336426931 0.425437233454919 no 1945 0.423117944460104 2843 1372513 SGTC_3071 9117417 49.47 µM -0.193990768057481 0.425409498340193 no 1946 0.423091555308133 2832 45595590 YGL055W OLE1 SGTC_2406 ethylparaben 405.7 µM -0.194501210495562 0.425199474961376 no 1947 0.422891723994374 2726 8434 A possible steroid mimic. SGTC_660 4031-1742 102 µM -0.195066173730049 0.42496704355491 no 1948 0.422670571658209 2726 6738706 SGTC_2761 levamisole 97.89 µM -0.195615800701775 0.424740946665452 no 1949 0.422455446020489 2871 26879 An alkaline phosphatase inhibitor. SGTC_182 3448-4371 550.524 µM -0.196216758903337 0.424493762278891 no 1950 0.422220255657395 2731 3491403 SGTC_92 0063-0024 660.874 µM -0.196767736511097 0.424267161853863 no 1951 0.422004650012277 2687 3594437 SGTC_1151 3909-8316 15.3 µM -0.197375254777014 0.42401733698589 no 1952 0.421766946272617 2845 800431 SGTC_2175 5807670 165.306 µM -0.197851609852843 0.423821470655486 no 1953 0.421580582700022 2847 241186 SGTC_1111 tnp00062 510.699 nM -0.198265281060428 0.423651393765178 no 1954 0.421418757076134 2901 676306 SGTC_1670 st016595 4.04 µM -0.198750126926056 0.423452072212421 no 1955 0.421229105260686 2761 597879 SGTC_180 1486-1293 102.781 µM -0.202264241430311 0.42200799801055 no 1956 0.419855076697565 2831 4140536 SGTC_1124 fisetin 1.16336 µM -0.202703554511103 0.421827541993079 no 1957 0.419683372378622 2835 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1003 4049-0218 100 µM -0.203020510807192 0.421697356490853 no 1958 0.419559500368293 2923 295161 SGTC_3129 9127257 49.47 µM -0.203273467738821 0.421593463999436 no 1959 0.41946064613658 2797 837894 SGTC_1507 4075-3230 155 µM -0.203328489454677 0.421570866633291 no 1960 0.41943914461371 2718 659771 SGTC_2903 5923464 63.88 µM -0.203384606793359 0.421547819561948 no 1961 0.419417215188409 2861 2876576 SGTC_633 0437-0093 97.7 µM -0.204091627412954 0.421257473269048 no 1962 0.419140948498481 2755 2831118 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.205516684236818 0.420672387275221 no 1963 0.418584232082424 2790 390807 SGTC_1893 st059353 36.1 µM -0.205801544942 0.420555452902346 no 1964 0.418472967172385 2815 3112488 SGTC_2866 9034245 58.44 µM -0.206054633362007 0.420451566827611 no 1965 0.418374117801115 2866 6462273 SGTC_1901 st060216 58.6 µM -0.206115870973489 0.42042643124672 no 1966 0.418350200849777 2773 688792 SGTC_1686 st019653 115.5 µM -0.206894842243236 0.420106723165164 no 1967 0.418045992333317 2884 97252 SGTC_10 0279-0212 42.575 µM -0.207462660978673 0.419873710239277 no 1968 0.417824275248502 2798 39851 YBR002C RER2 SGTC_1368 1852-0141 284 µM -0.20748706407515 0.419863696691899 no 1969 0.417814747117449 2894 2838987 SGTC_1343 1487-0095 224 µM -0.208115458887575 0.419605859547015 no 1970 0.417569408487314 2804 4560101 YGL055W OLE1 SGTC_505 gw-5074 63.9 µM -0.208135009770746 0.419597838162532 no 1971 0.41756177592301 2883 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_69 0096-0274 206.684 µM -0.209631576316125 0.418983922554986 no 1972 0.416977616426422 3060 6741392 SGTC_2856 9022925 19.48 µM -0.209820881076334 0.418906280725566 no 1973 0.416903737536918 2930 4944862 SGTC_3131 9127911 49.47 µM -0.210317166912782 0.418702748070498 no 1974 0.416710068829908 3022 45595681 SGTC_2962 9082311 13.18 µM -0.210520021668026 0.418619561212885 no 1975 0.416630913374863 2764 16459453 SGTC_1436 4092-1007 8.32 µM -0.210792584268559 0.418507794230836 no 1976 0.416524562715741 2789 2881121 SGTC_2651 TUB2.036 5 µM -0.211179059315184 0.418349327606516 no 1977 0.416373775261734 2880 15992207 YFL037W TUB2 SGTC_2736 butenafine 14.65 µM -0.212240833117502 0.417914036066234 no 1978 0.415959576044882 2812 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2697 mebhydrolin 72.4 µM -0.213031253421799 0.417590055583703 no 1979 0.415651292723973 2920 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1742 st038235 28.8875 µM -0.214079876171157 0.417160328456276 no 1980 0.415242384251087 2911 564103 YBR002C RER2 SGTC_1877 wortmannin 25 µM -0.214309648183954 0.417066180748649 no 1981 0.415152797330366 2914 312145 A covalent inhibitor of PI 3-kinase. SGTC_1332 1480-0653 17.5 µM -0.214387357749642 0.417034340794878 no 1982 0.415122499770206 2839 5749438 SGTC_88 0180-0332 8.668 µM -0.21487531024539 0.416834424378294 no 1983 0.414932267422273 2760 3101745 SGTC_2588 indole-3-carbinol 100 µM -0.215562240782775 0.416553022186646 no 1984 0.414664495638561 2929 3712 Induces cell cycle arrest. SGTC_558 k064-0027 21.3 µM -0.216268033311099 0.416263937687708 no 1985 0.414389412575685 2906 5088526 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.216777668999843 0.416055224923514 no 1986 0.414190807855503 2939 5393153 SGTC_84 0443-0269 128.823 µM -0.216948125920605 0.415985422425239 no 1987 0.414124385790328 2784 6150058 SGTC_646 4092-0839 27.3 µM -0.217106063993686 0.415920748789048 no 1988 0.414062844145366 2932 877796 SGTC_3021 9087658 49.47 µM -0.217111734060064 0.415918427011166 no 1989 0.414060634804646 2812 25237042 SGTC_504 lovastatin 124 µM -0.217181976299755 0.41588966447339 no 1990 0.414033265149498 2803 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_724 3910-0327 137 µM -0.217358015630152 0.415817582506068 no 1991 0.413964673844443 2845 2885483 SGTC_251 melphalan 456.522 µM -0.218591451631043 0.415312613045494 no 1992 0.413484156192365 2861 460612 A DNA alkylator. SGTC_2146 5545642 200 µM -0.218740038315996 0.415251790986859 no 1993 0.413426279043745 2800 825326 SGTC_2850 9015429 58.44 µM -0.219663141862747 0.414873975913343 no 1994 0.413066756034831 2858 6457570 SGTC_1645 Cervolide 78 µM -0.220059886694024 0.414711617238858 no 1995 0.412912257401664 2869 23173 A fragrance. SGTC_3354 9151612 71.43 µM -0.220599717809542 0.414490727203758 no 1996 0.412702060401717 2938 27261949 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.221025991862328 0.414316321957674 no 1997 0.412536097420795 2780 91467 include heat shock SGTC_2995 9067767 71.4286 µM -0.221671117618129 0.414052408132611 no 1998 0.412284957778814 2891 11673567 SGTC_2791 5663188 71.43 µM -0.223020834855724 0.413500379375901 no 1999 0.411759645488768 2972 54690634 SGTC_1704 st028805 70.8 µM -0.224976514024748 0.412700818234676 no 2000 0.410998772513709 2851 2876101 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.225998419707921 0.412283165469604 no 2001 0.410601324712952 2849 688788 SGTC_2730 imipramine 71.33 µM -0.226383993146972 0.412125607418472 no 2002 0.410451388207391 2809 3696 A tricyclic antidepressant. SGTC_1795 st049545 62.3 µM -0.228569419099778 0.411232838499918 no 2003 0.409601797693722 2795 5291882 SGTC_3197 9113331 49.47 µM -0.229535256036355 0.410838430338589 no 2004 0.409226460817034 3023 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_425 3825-7017 13.1 µM -0.229813002473057 0.410725026762459 no 2005 0.409118540304595 3060 3397440 SGTC_606 k015-0008 38.6 µM -0.23118296490994 0.410165781901738 no 2006 0.408586331803123 2951 1970475 SGTC_916 4466-0038 42 nM -0.232068529804038 0.409804374502196 no 2007 0.40824239362301 2985 5722064 YGL116W CDC20 SGTC_496 calpeptin 138 µM -0.232469358224553 0.409640817806058 no 2008 0.408086741974805 2879 73364 A calpain inhibitor. SGTC_528 3492-0019 172 µM -0.233054241931836 0.409402186184456 no 2009 0.407859643107369 2880 2869262 SGTC_3120 9124077 49.47 µM -0.234947422206227 0.40863000223048 no 2010 0.407124770978523 2798 18774327 YGL155W CDC43 SGTC_980 1473-0395 201 µM -0.235999968410064 0.408200846419798 no 2011 0.406716347343715 2814 768876 SGTC_1933 st074711 15.9 µM -0.236326578137702 0.40806769983649 no 2012 0.406589632291608 2776 17250958 SGTC_2683 piperine 63.03 µM -0.238221523897412 0.407295411164936 no 2013 0.405854641969284 2852 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2219 9098279 200 µM -0.238553219856409 0.407160264821344 no 2014 0.405726021501697 2843 902349 SGTC_772 k072-0172 35.3 µM -0.239918390697957 0.406604155548203 no 2015 0.405196761733379 2854 5861980 SGTC_2729 fluphenazine 10.66 µM -0.241554803238457 0.405937802810746 no 2016 0.40456257340603 2824 3372 An atypical antipsychotic. SGTC_1053 3366-3204 134 µM -0.241761651267915 0.405853592945551 no 2017 0.404482427685677 2885 3632071 YPR165W RHO1 SGTC_357 1325-0123 420 µM -0.2418778009271 0.405806309187616 no 2018 0.404437425880625 2964 1098503 SGTC_840 0245-0196 390 µM -0.242537827899022 0.405537642684672 no 2019 0.40418172461351 2964 3827528 SGTC_1232 0279-0259 161 µM -0.247772511791748 0.403408430401724 no 2020 0.402155212136314 2854 1560000 SGTC_1762 st045503 25.4615 µM -0.248203672710717 0.403233181951508 no 2021 0.401988412419048 2927 4645554 SGTC_1559 coumarin 343 70.1 µM -0.2482526523052 0.403213275072284 no 2022 0.401969465210233 3001 108770 A hepatotoxic, DNA x-linker. SGTC_355 1311-2252 105 µM -0.248277671448995 0.403203106586022 no 2023 0.40195978692292 2857 5338538 SGTC_3075 9116269 49.47 µM -0.248391637269657 0.403156788487769 no 2024 0.401915701684325 3045 17015205 YNL244C SUI1 SGTC_1651 st011928 86.1 µM -0.248653320562625 0.40305044005529 no 2025 0.401814479826499 2961 720198 SGTC_2544 sphondin 68.51 µM -0.249149404071037 0.402848850758008 no 2026 0.401622607575848 3066 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_3322 9139058 2.11 µM -0.249552593552485 0.402685029048052 no 2027 0.401466681795213 3029 4908926 YPR165W RHO1 SGTC_747 3448-8087 38.7 µM -0.250364009054065 0.402355391028178 no 2028 0.401152930028872 2905 5168703 SGTC_343 4130-2827 29.8 µM -0.251256051218557 0.401993078499452 no 2029 0.400808075731561 2899 1118244 SGTC_676 falcarinol 140 µM -0.253276568377233 0.401172735522225 no 2030 0.400027250820784 3036 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_272 doxorubicin 8.13 µM -0.25378305519482 0.400967166736151 no 2031 0.399831582483162 2830 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2003 4023581 200 µM -0.254358831213904 0.400733508709874 no 2032 0.399609176567527 3006 16641307 SGTC_3219 9131112 49.47 µM -0.256837507369266 0.399728033475641 no 2033 0.398652107170729 2932 17612988 YMR079W SEC14 SGTC_726 3448-4391 34.2 µM -0.257062695901198 0.399636718555541 no 2034 0.398565187205227 3035 1356692 SGTC_1604 st002052 72.4 µM -0.257369906159898 0.399512152325173 no 2035 0.398446615990848 2982 6254834 YHR062C RPP1 SGTC_1608 st001473 40.5 µM -0.257948996714812 0.399277373120107 no 2036 0.398223135052932 2851 7292267 SGTC_2274 7947094 46.08 µM -0.258430204931885 0.399082305807809 no 2037 0.398037453972085 2853 2971028 SGTC_1210 3013-0140 750 nM -0.259738451178079 0.398552109707899 no 2038 0.3975327652579 3009 905973 SGTC_3315 9136395 68.55 µM -0.26076748447155 0.398135202385146 no 2039 0.397135910361941 3023 16876844 SGTC_2102 5377816 72.7585 µM -0.260786156604079 0.398127638543319 no 2040 0.3971287102875 3058 1379702 SGTC_3324 9138759 60.749 µM -0.261069270868991 0.398012957271659 no 2041 0.397019544205914 2995 45595710 SGTC_89 0302-0250 142.109 µM -0.261248072949396 0.397940534340206 no 2042 0.39695060403518 2842 4203518 YLR208W SEC13 SGTC_181 1447-1644 8.07 µM -0.261635706187815 0.397783537421277 no 2043 0.39680115653513 2968 534600 SGTC_1073 triclabendazole 3.09 µM -0.261844291956914 0.397699064096294 no 2044 0.396720744981253 2936 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2889 9059656 51.95 µM -0.262979072327259 0.397239583452806 no 2045 0.396283354705415 2963 3949838 SGTC_1082 camptothecin 424.86 nM -0.263204984165489 0.397148127139983 no 2046 0.396196294701248 2737 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3136 9095672 49.47 µM -0.263414971596614 0.397063122605995 no 2047 0.396115376153125 2775 17217380 SGTC_607 4491-0986 66.8 µM -0.263635674846051 0.39697378549668 no 2048 0.396030333094236 3019 698981 YDR232W HEM1 SGTC_2275 7947463 200 µM -0.263654410020513 0.396966202049654 no 2049 0.396023114141754 2967 1225414 SGTC_1122 capsaicin 818.572 nM -0.263903810180673 0.396865255919989 no 2050 0.395927019800496 3004 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_926 2268-1401 59.4 µM -0.265028617516406 0.396410069727926 no 2051 0.395493708126052 2849 2931578 SGTC_2908 7930301 100 µM -0.265175987194574 0.396350442722303 no 2052 0.395436946182234 2877 2223178 SGTC_913 3487-1245 167 µM -0.267334075816388 0.39547754038548 no 2053 0.394605976237002 2832 4016153 SGTC_1346 1488-2224 62.4 µM -0.267456466437772 0.3954280515673 no 2054 0.394558864173423 2960 3722427 SGTC_1392 3455-1037 33.9 µM -0.26768805752194 0.395334412004898 no 2055 0.3944697215805 3026 981132 SGTC_2125 5246583 200 µM -0.267935081302859 0.395234539178157 no 2056 0.394374644821284 3003 835267 SGTC_292 k038-0015 474 µM -0.2684483643158 0.395027038557145 no 2057 0.39417710791548 2994 46368540 SGTC_2985 9022375 71.43 µM -0.268721924818665 0.39491646070215 no 2058 0.394071839303966 3075 4939335 SGTC_669 0108-0021 26.2 µM -0.268859284114788 0.394860940906134 no 2059 0.394018985094218 3012 17201 SGTC_1940 st075990 51.1 µM -0.268950885485161 0.394823917373256 no 2060 0.393983739070304 3137 1084979 SGTC_686 1319-0111 510 µM -0.26943061292412 0.394630036179743 no 2061 0.393799165574521 3044 4562600 SGTC_275 trichlorophene 5.69 µM -0.269461884668497 0.394617398652176 no 2062 0.393787134705315 2978 62616 SGTC_1730 st033808 45.1 µM -0.269900826842892 0.394440025186691 no 2063 0.393618275523188 2871 1045166 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.27009061592922 0.394363339517903 no 2064 0.39354527066392 2981 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_927 2425-1185 123 µM -0.270158347542983 0.394335973054984 no 2065 0.393519217716979 2853 730375 SGTC_456 gingerol 170 µM -0.270566777321451 0.39417096105152 no 2066 0.393362125421587 3064 442793 A herb. SGTC_1981 st071826 47 µM -0.271121857819606 0.393946730322208 no 2067 0.393148655427971 2977 11838600 SGTC_2983 9022671 12.99 µM -0.27259776811926 0.39335069168949 no 2068 0.392581213885886 3084 6405161 SGTC_1590 st077108 57.8 µM -0.273205594069437 0.39310529692812 no 2069 0.392347590031153 2985 5489485 SGTC_2698 st077697 67.5 µM -0.273844181951982 0.392847528542395 no 2070 0.392102184315306 2926 3154499 SGTC_935 2996-0153 430 µM -0.274443707752098 0.392605570470345 no 2071 0.391871828989573 3061 23738523 SGTC_2894 9048625 32.47 µM -0.275215151204495 0.392294290525439 no 2072 0.391575473648872 3065 4092861 SGTC_578 3460-0051 92 µM -0.275221667489754 0.392291661476314 no 2073 0.391572970640521 2963 2876744 SGTC_1614 st002383 48.6 µM -0.275301032935638 0.392259641226075 no 2074 0.391542485476363 2935 1947235 SGTC_1454 4239-0054 42.6 µM -0.275758349553484 0.392075149550612 no 2075 0.391366837980464 3076 1340767 SGTC_1179 1021-1431 9.29 µM -0.275871306371709 0.392029583997288 no 2076 0.391323456607148 2960 2840958 SGTC_2142 5622915 118.518 µM -0.277205951378178 0.391491314966157 no 2077 0.390810985048404 2933 5322196 SGTC_995 3931-2021 34.6 µM -0.279129450037633 0.390715923906777 no 2078 0.390072741549152 2997 730143 SGTC_405 ebelactone b 50 µM -0.279419676390822 0.390598966962912 no 2079 0.389961386307139 2887 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1133 3473-0247 50 µM -0.279538379532477 0.390551134197226 no 2080 0.389915844398494 2955 711311 SGTC_368 fentichlor 4.58 µM -0.279553332936156 0.390545108672528 no 2081 0.389910107449879 2965 7329 A pesticide. SGTC_910 3454-3003 490 µM -0.281315985614746 0.389835026347863 no 2082 0.389234025223336 3018 820824 SGTC_366 0181-0206 4.31 µM -0.281568947717487 0.389733150997335 no 2083 0.38913702665497 3091 274874 SGTC_1699 st031318 29.054 µM -0.283271990250627 0.389047482703656 no 2084 0.388484173418881 3009 5340658 SGTC_341 1486-1430 230 µM -0.283520358208909 0.388947515164492 no 2085 0.388388989013632 2875 2054753 YPL210C SRP72 SGTC_2347 9049783 174.81 µM -0.287687171678986 0.387271483408117 no 2086 0.386793105300483 3082 6467988 YPL169C MEX67 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.287727248729915 0.387255373220552 no 2087 0.386777765088393 2975 6857784 SGTC_378 3970-0959 8.33 µM -0.288330626428658 0.387012850716316 no 2088 0.386546832813522 3037 6615653 SGTC_1597 7-benzyloxygramine 47.5 µM -0.288685074525734 0.3868704038938 no 2089 0.386411192721495 2909 260807 SGTC_356 1634-0012 32.5 µM -0.290498854238004 0.386141714729455 no 2090 0.385717313596374 3038 735457 SGTC_2302 7771753 200 µM -0.290541662519613 0.386124521267054 no 2091 0.385700941277489 2993 2203047 SGTC_1271 0832-2808 169 µM -0.291403921688014 0.385778252281827 no 2092 0.385371207781446 3072 3663794 SGTC_2479 5617353 43.85 µM -0.293581814183114 0.384904052527265 no 2093 0.384538736944963 3084 2731746 SGTC_2545 solidagenone 89.61 µM -0.29426149891097 0.384631348555409 no 2094 0.384279045147302 2846 6708572 An anti ulcer agent SGTC_874 0599-0792 117 µM -0.294518336019387 0.384528314895195 no 2095 0.384180927149156 3092 765305 SGTC_167 3672-0051 66.205 µM -0.29497752741272 0.384344124424001 no 2096 0.384005523411465 2872 3237971 SGTC_1997 st073024 93.8 µM -0.295209477012733 0.384251094916059 no 2097 0.383916931418208 3059 686268 SGTC_95 0471-0001 561.058 µM -0.296436297426838 0.383759157227559 no 2098 0.383448454472611 2934 4015405 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.297759704988228 0.383228699438479 no 2099 0.382943285504177 2908 442882 SGTC_775 4577-0580 57.3 µM -0.298793228505442 0.382814587213074 no 2100 0.382548908965547 3119 2006902 SGTC_2306 7482397 179.52 µM -0.299567597839604 0.382504400625592 no 2101 0.382253501418029 3097 891448 SGTC_1245 0418-0076 17.2 µM -0.302496876319777 0.381331712473213 no 2102 0.381136657163994 3107 6790114 SGTC_2423 st077119 87.2 µM -0.303600090910083 0.380890340408193 no 2103 0.380716291155381 2936 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_466 geldanamycin 89.2 µM -0.306005134738428 0.379928672677389 no 2104 0.379800368120579 2998 5288382 HSP90 inhibitor. SGTC_2742 clothiapine 36.27 µM -0.307063605995063 0.379505672901348 no 2105 0.379397479277696 3003 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.307881311692752 0.379178989613927 no 2106 0.379086323315019 2969 115019 SGTC_2015 5119600 184 µM -0.30849969090545 0.378931996932956 no 2107 0.378851067701083 3137 2828786 SGTC_1717 st033143 58.0435 µM -0.310103690837112 0.378291558787275 no 2108 0.378241052822686 3123 674616 SGTC_1075 aripiprazole 15.2 µM -0.310238996597186 0.378237549751173 no 2109 0.378189608740152 2927 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2508 celastrol 40.54 µM -0.310361047270543 0.378188833694445 no 2110 0.378143206175596 2973 122724 Celastrol is a natural product and antioxidant. SGTC_3349 9149703 23.001 µM -0.310913287592665 0.377968433308702 no 2111 0.377933271366821 2915 4910494 SGTC_2407 paclitaxel 400 µM -0.312080517432526 0.377502719944457 no 2112 0.377489666237826 3166 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1437 4092-1038 11.6 µM -0.313649840005347 0.376876856207468 no 2113 0.376893500693673 2968 3977136 SGTC_100 0086-0128 49.5915 µM -0.314157080528992 0.376674631980552 no 2114 0.376700869188806 3004 93297 SGTC_545 4218-0007 221 µM -0.314291876060919 0.376620898030609 no 2115 0.376649683907987 3074 2840508 SGTC_773 4358-1457 44.6 µM -0.31704886108601 0.375522398569779 no 2116 0.375603263723196 3136 1186886 SGTC_2640 pentamidine 10.38 µM -0.318080949005744 0.375111430007584 no 2117 0.37521176712416 3070 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1138 3761-0006 1.03 µM -0.318119780028324 0.375095970591078 no 2118 0.37519704005818 2968 12061087 SGTC_909 3448-9333 149 µM -0.318924641355634 0.374775584211435 no 2119 0.374891829088439 2947 3344074 SGTC_2967 9089538 49.85 µM -0.319593399905291 0.374509441175403 no 2120 0.374638289146732 3197 728216 SGTC_970 1315-0089 19.5 µM -0.321755186350512 0.373649533592224 no 2121 0.373819083204641 3001 6811083 YLR033W RSC58 SGTC_2523 spermine 47.74 µM -0.321905985382297 0.373589572706089 no 2122 0.373761959336347 3084 1103 A DNA binding polyamine. SGTC_2801 7907800 81.82 µM -0.323148722113637 0.373095550922551 no 2123 0.373291306506672 3069 6620925 SGTC_1281 0884-0031 11.8 µM -0.323385646895651 0.373001390501087 no 2124 0.373201599099421 2994 1548255 SGTC_1230 0170-0365 3.77 µM -0.323819649219985 0.372828925725684 no 2125 0.373037289571798 3091 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3016 9080866 49.47 µM -0.323911385101279 0.372792474786092 no 2126 0.373002562115474 2974 17066299 SGTC_160 3453-0671 289.699 µM -0.32437192981832 0.372609496132109 no 2127 0.372828234302696 2977 5322268 SGTC_2855 9016525 58.44 µM -0.324616323437635 0.372512407970254 no 2128 0.372735735716053 2943 43811474 SGTC_1664 st014217 9.02 µM -0.325030777370868 0.372347779922378 no 2129 0.372578889137456 3022 3982782 SGTC_595 3909-8003 73.7 µM -0.325629635739495 0.372109944548822 no 2130 0.372352293588519 3111 699517 SGTC_1014 4130-3005 69.3 µM -0.326055368930309 0.371940895145711 no 2131 0.37219123187114 2977 743608 SGTC_1930 st074634 34.3 µM -0.326523176599231 0.37175516734542 no 2132 0.372014278481683 2957 684253 YOR116C RPO31 SGTC_3070 9117005 49.47 µM -0.326960270444653 0.371581660436341 no 2133 0.37184896735675 3031 8779016 SGTC_1113 artemisinin 1.17947 µM -0.327139823444264 0.371510393400227 no 2134 0.371781066338838 3082 2240 An anti-malaria and mitochondrial poison. SGTC_2052 5265182 7.135 µM -0.327200529496199 0.371486299335807 no 2135 0.3717581102158 3144 1239884 SGTC_1663 st014140 55.4 µM -0.327609241740171 0.371324095685822 no 2136 0.371603566681898 3012 4207120 SGTC_649 1123-0311 367 µM -0.327770738151492 0.371260009683629 no 2137 0.371542506862925 3088 693629 YIL048W NEO1 SGTC_1127 asiatic acid 681.4 nM -0.328023047159287 0.371159894011613 no 2138 0.371447118381055 2974 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1925 st057770 10.1 µM -0.328738044630235 0.370876231932661 no 2139 0.371176847812798 2985 5989122 SGTC_1666 st014829 29 µM -0.329044253832218 0.37075477051919 no 2140 0.371061119501009 2938 3858230 SGTC_1788 fluconazole 20 µM -0.330238101301153 0.370281340234679 no 2141 0.370610029761475 3083 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3106 9121286 49.47 µM -0.33046759275331 0.370190355951472 no 2142 0.370523337836113 3190 15943471 SGTC_864 0469-0573 172 µM -0.331766425546419 0.369675557136059 no 2143 0.370032819109929 2979 689425 SGTC_2187 6125751 200 µM -0.332555232227943 0.369363023606892 no 2144 0.369735020542611 3017 874498 SGTC_1523 st012844 44.7 µM -0.332699788238173 0.369305758342992 no 2145 0.369680454706086 3103 4274103 SGTC_314 1671-0008 2.74 µM -0.332816164772778 0.369259658368447 no 2146 0.369636527737368 2979 3913060 SGTC_3142 9086498 49.47 µM -0.333368316422123 0.369040961410425 no 2147 0.369428138227778 3085 25236367 SGTC_2163 5671233 125 µM -0.334610160088397 0.368549245294388 no 2148 0.368959589836539 3212 701023 SGTC_854 0422-0053 192 µM -0.335309069712595 0.368272602031839 no 2149 0.368695976362235 3016 3596728 SGTC_1344 1488-0097 29.1 µM -0.336015465343846 0.367993065030985 no 2150 0.36842960209643 3102 747966 SGTC_2741 miltefosine 3.04 µM -0.337656400438744 0.367343979234916 no 2151 0.367811067155885 3006 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2285 7945142 200 µM -0.337867193808662 0.367260625551457 no 2152 0.367731635393879 3109 2970608 SGTC_1193 1488-0126 41.5 µM -0.340468980321672 0.366232321480972 no 2153 0.36675168952923 3031 1384710 SGTC_2467 5474540 200 µM -0.340893247805072 0.366064729074804 no 2154 0.366591974084279 3003 5413519 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.341241799227465 0.36592706483263 no 2155 0.366460779223174 2967 6708630 An antioxidant. SGTC_2461 5755302 26.15 µM -0.342227174956554 0.365537973205679 no 2156 0.366089967955567 3150 2788904 SGTC_794 k038-0031 316 µM -0.342791201799231 0.365315320256686 no 2157 0.365877772666224 3062 6624242 SGTC_786 4544-0069 423 µM -0.342964581881014 0.365246886555553 no 2158 0.365812552740567 3114 748821 YLR208W SEC13 SGTC_75 0159-0059 199.013 µM -0.34495714792146 0.364460722542547 no 2159 0.365063293276672 3301 5377270 SGTC_21 0849-0113 22.993 µM -0.346400868756206 0.363891460369339 no 2160 0.364520736154093 3021 1560156 SGTC_1314 1222-0010 41.1 µM -0.346989072120229 0.363659616557025 no 2161 0.364299764264253 3073 3526027 SGTC_2625 euphol 100 µM -0.347117015230715 0.363609193635016 no 2162 0.364251705511676 3159 6708538 A triterpene alcohol. SGTC_1927 st060202 13.8 µM -0.349137121705274 0.362813374757457 no 2163 0.363493184432772 3106 688887 SGTC_3252 9135871 49.47 µM -0.349146238190251 0.362809784667205 no 2164 0.363489762533222 3171 17682838 SGTC_2740 felodipine 17.08 µM -0.349172533654973 0.362799429527484 no 2165 0.363479892513924 3098 3333 L-type calcium channel blocker SGTC_984 1492-0255 2.91 µM -0.350269107282052 0.362367688845748 no 2166 0.3630683736711 3130 1585198 SGTC_3279 9140807 49.47 µM -0.350632868057598 0.362224508338109 no 2167 0.362931897509904 3044 45595718 SGTC_2154 5570129 200 µM -0.351136006787233 0.362026498802812 no 2168 0.362743158067959 3067 673366 SGTC_1798 st045719 60.953 µM -0.351849731060503 0.361745676971674 no 2169 0.362475480126848 3101 3980186 SGTC_493 zm226600 134 µM -0.351880249386998 0.361733670894558 no 2170 0.362464035911953 3196 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2706 st078239 82.5 µM -0.351949648391036 0.361706369452202 no 2171 0.362438012101194 3034 15434492 SGTC_1360 1598-0022 39.8 µM -0.352918438942663 0.361325322564954 no 2172 0.362074793451199 3136 761525 SGTC_988 1497-1057 103 µM -0.354119225464628 0.360853217400603 no 2173 0.361624767303125 3120 3533044 SGTC_911 3456-4043 236 µM -0.358180648531582 0.359257989476026 no 2174 0.360104064042738 3112 914281 SGTC_2918 7977171 22.06 µM -0.358928608344583 0.358964475471083 no 2175 0.359824248674564 3026 2236483 SGTC_3007 9078383 71.4286 µM -0.35941495822788 0.358773666951148 no 2176 0.359642343130697 3050 6496995 SGTC_1327 1436-0082 2.18 µM -0.359711916780804 0.358657179215853 no 2177 0.359531289737281 3058 15992205 SGTC_1367 1812-0510 76.9 µM -0.359721918524027 0.358653256067454 no 2178 0.359527549598431 3091 1142582 YDR527W RBA50 SGTC_2029 5175081 200 µM -0.360052526362626 0.358523584708997 no 2179 0.359403926803662 3027 1380876 SGTC_576 1073-0113 22.7 µM -0.360905193855111 0.358189225865146 no 2180 0.359085160387086 3126 5439563 SGTC_3193 9111931 49.47 µM -0.3634015841587 0.357210935443972 no 2181 0.358152459281124 3015 17087244 SGTC_1650 st011916 45.8 µM -0.364271507086817 0.356870248332941 no 2182 0.357827637215236 3179 242528 SGTC_1797 st048695 56.8 µM -0.365161295163245 0.356521899509902 no 2183 0.357495504136035 3158 592262 YIL048W NEO1 SGTC_184 1494-0393 24.714 µM -0.365568141832952 0.356362660352454 no 2184 0.357343675551127 3005 3090647 SGTC_1015 4130-4525 82 µM -0.367060109297011 0.355778921070089 no 2185 0.356787090862035 3067 1363237 SGTC_2837 9008476 45.46 µM -0.367143528822116 0.355746292754297 no 2186 0.356755979845382 3216 2992805 SGTC_2377 9073351 62.6 µM -0.36730342625745 0.355683754187323 no 2187 0.356696349326477 3033 7337946 YHR072W ERG7 SGTC_1904 st060225 78 µM -0.367614977620258 0.355561912386324 no 2188 0.356580172599053 3097 66595 SGTC_674 0498-0004 451 µM -0.368207350496708 0.355330287358219 no 2189 0.356359314935587 3112 4231473 SGTC_1892 st058411 7.36 µM -0.369381357338762 0.354871394297975 no 2190 0.35592174584801 3163 3934738 SGTC_1469 k284-2957 126 µM -0.371714144363768 0.35396018510458 no 2191 0.355052846378627 3089 23884841 SGTC_1565 sinapyl alcohol 95.1 µM -0.372013375041269 0.353843363077839 no 2192 0.354941445534123 3149 5280507 A phenol propionate derived from cinnamic acid. SGTC_516 3992-2719 87.3 µM -0.372985134209362 0.353464075552685 no 2193 0.354579754051728 2980 5350887 YDR037W KRS1 SGTC_1876 myriocin 605 nM -0.373183267778232 0.353386759838645 no 2194 0.354506024259913 3241 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1049 3226-0134 66 µM -0.376090354425178 0.352253053073536 no 2195 0.353424862440742 3131 5702385 SGTC_579 4491-1009 110 µM -0.377404613647153 0.351740947670374 no 2196 0.352936469382798 3203 1271041 SGTC_819 1013-0258 27.7 µM -0.37823533131761 0.351417394443285 no 2197 0.352627890512904 3082 5753198 SGTC_670 4204-0025 119 µM -0.378491234937333 0.351317745140799 no 2198 0.352532851928042 3160 719039 SGTC_1432 4049-0298 68.4 µM -0.378759913957427 0.351213132073637 no 2199 0.352433078665733 3166 741646 SGTC_1433 4060-0023 7.6 µM -0.379526865351491 0.350914573336749 no 2200 0.352148329116667 3195 3840627 SGTC_829 1635-0120 117 µM -0.380916348978776 0.350373909817314 no 2201 0.351632660352913 3209 285054 SGTC_163 TUB2.036 7.546 µM -0.381243514610096 0.350246650070843 no 2202 0.351511281451903 3172 15992207 YJR013W GPI14 SGTC_3167 9103034 49.47 µM -0.382469194887999 0.349770038804513 no 2203 0.351056687060806 3126 5127859 SGTC_475 α-linolenic acid 10 µM -0.382611022654942 0.349714903704056 no 2204 0.351004098090316 3300 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_319 1348-1596 45.5 µM -0.382939247484549 0.3495873194854 no 2205 0.350882405040326 3250 5380505 SGTC_782 0083-0095 30.5 µM -0.383752314539112 0.349271345514825 no 2206 0.350581017172252 3038 3591729 An indicator and reagent. SGTC_1965 Pectolinarigenin 58.4 µM -0.384924695497317 0.348815918955978 no 2207 0.350146604325495 3089 5320438 An anti-inflammatory. SGTC_2869 9037858 32.47 µM -0.384933113342947 0.34881264972144 no 2208 0.35014348589363 3032 27187042 SGTC_568 1193-0097 7.48 µM -0.385366339198531 0.348644413169739 no 2209 0.34998300891407 3161 3646150 SGTC_3018 9082602 49.47 µM -0.385636215092058 0.348539626088165 no 2210 0.349883054117789 3157 17332089 SGTC_1746 st038117 42 µM -0.386152913109918 0.348339035462687 no 2211 0.349691712051515 3152 2898218 SGTC_1948 st076329 66.6 µM -0.389600772814362 0.347001608020064 no 2212 0.348415890294446 3038 24208413 SGTC_3137 9097352 49.47 µM -0.390321549166366 0.346722258345251 no 2213 0.348149395291523 3374 44120435 SGTC_1090 efavirenz 20.7 µM -0.390850985860429 0.346517118816965 no 2214 0.347953692675731 3126 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_797 k781-0471 270 µM -0.391065884387126 0.34643386545314 no 2215 0.347874268471257 3079 23738129 SGTC_354 2783-3500 4.88 µM -0.391260066282218 0.346358644253577 no 2216 0.347802506653235 3107 6740761 SGTC_123 0083-0120 66.675 µM -0.391858400939683 0.346126902515085 no 2217 0.347581420521326 3110 16001701 SGTC_891 0929-0073 133 µM -0.392548011400101 0.345859880097275 no 2218 0.347326672052747 3215 5603632 SGTC_129 0088-0017 176.636 µM -0.393024284289485 0.345675508348159 no 2219 0.347150772700924 3211 182446 SGTC_3064 1327-0027 10 µM -0.393684976774725 0.345419805855126 no 2220 0.346906817154045 3071 16000455 YPR107C YTH1 SGTC_541 4513-1321 94 µM -0.394083815354173 0.345265480702721 no 2221 0.346759579824042 3113 747515 SGTC_1496 4469-0713 57.4 µM -0.395216902085687 0.344827188663066 no 2222 0.34634140993744 3217 746691 SGTC_1830 st055982 50.3 µM -0.395280430278393 0.344802621325269 no 2223 0.346317970159301 3212 455313 An antimicrobial agent. SGTC_507 nimesulide 162 µM -0.39626663346234 0.344421325238513 no 2224 0.345954169713808 3287 4495 A COX2 inhibitor. SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.397501679908909 0.343944041724582 no 2225 0.345498773994721 3332 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_198 3454-2873 16.191 µM -0.397786890384633 0.343833857478741 no 2226 0.345393640765644 3121 710957 SGTC_1339 1486-1321 22.7 µM -0.398990593546271 0.343368981749466 no 2227 0.34495006763916 3124 3469382 SGTC_1479 0549-0158 134 µM -0.401320316823287 0.342469905220179 no 2228 0.344092153642924 3145 5440202 SGTC_2073 5212005 126 µM -0.401791344050952 0.342288236697949 no 2229 0.343918796510294 3126 691789 SGTC_1674 st016616 23.6 µM -0.402659323036196 0.341953565111705 no 2230 0.343599430971999 3069 625830 SGTC_2914 7968218 45.32 µM -0.403996763348413 0.341438123744685 no 2231 0.34310754963592 3190 2977111 SGTC_2788 5282734 71.43 µM -0.407231163188419 0.340192829114129 no 2232 0.341919107703328 3267 743706 SGTC_2739 tacrine 100.86 µM -0.410443606289699 0.338957711089269 no 2233 0.340740281920785 3229 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2982 9019404 25.97 µM -0.410707970866883 0.338856145196402 no 2234 0.340643340745911 3111 22333232 SGTC_1960 st011366 51.8 µM -0.413372148698047 0.337833253026229 no 2235 0.339666988431943 3112 3972846 SGTC_2056 5235370 200 µM -0.413611064560779 0.337741581327515 no 2236 0.339579484365876 3117 5511916 SGTC_2028 5153890 36.43 µM -0.414517693807227 0.337393796496505 no 2237 0.339247505808427 3133 2830968 YPR165W RHO1 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.417871163020474 0.336108607620677 no 2238 0.33802065867259 3342 804 An inhibitor of viral and cellular DNA polymerases. SGTC_662 k832-1615 104 µM -0.417907175958228 0.336094816323581 no 2239 0.338007492853033 3216 5878478 SGTC_1156 4092-0367 4.88 µM -0.419564818765806 0.335460254508771 no 2240 0.337401696831424 3182 1357585 SGTC_3041 9091929 49.47 µM -0.42021879243705 0.335210035948204 no 2241 0.337162813810354 3313 25236887 SGTC_2072 5231554 129 µM -0.421710350679022 0.334639620620295 no 2242 0.336618224224377 3285 789545 SGTC_13 0199-0087 65 µM -0.422181787067899 0.334459408878803 no 2243 0.336446167124561 3193 4589825 SGTC_793 0488-0545 106 µM -0.423607204777254 0.333914759416279 no 2244 0.33592615002279 3117 292548 SGTC_1215 3852-0577 11.2 µM -0.424540717631331 0.333558255295169 no 2245 0.33558575839289 3298 2884876 SGTC_3112 9123419 49.47 µM -0.424739577956277 0.333482330884183 no 2246 0.335513264339849 3181 17015854 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.425899148776553 0.333039745358028 no 2247 0.335090667607204 3305 1273210 SGTC_769 0302-0231 76 µM -0.4259122837639 0.333034733320371 no 2248 0.335085881855603 3260 571869 YER009W NTF2 SGTC_2444 5485484 36.41 µM -0.427906819101377 0.332274006744005 no 2249 0.334359481121896 3258 6790631 SGTC_611 3453-1652 23.7 µM -0.431598682986657 0.330867733639991 no 2250 0.333016557910829 3270 1560575 SGTC_2184 6075246 200 µM -0.431882571716374 0.33075969561553 no 2251 0.332913381129147 3232 2267320 SGTC_283 0987-0079 11.7 µM -0.432376104042779 0.330571908200933 no 2252 0.332734041399631 3263 411556 SGTC_161 4065-0411 162.148 µM -0.432785769393033 0.330416064280462 no 2253 0.332585206306545 3252 1906281 YLR208W SEC13 SGTC_895 0964-0006 13.7 µM -0.433548689160356 0.330125914542169 no 2254 0.332308101057531 3286 6738897 SGTC_1299 1079-1439 3.74 µM -0.433799133151346 0.330030689225342 no 2255 0.332217155574381 3181 323161 SGTC_1976 st070609 63.5 µM -0.435056331538059 0.329552836193539 no 2256 0.331760769681601 3160 682556 SGTC_3111 9122088 49.47 µM -0.436065477450166 0.329169467521158 no 2257 0.331394611876425 3167 16876704 SGTC_372 0155-0182 15.9 µM -0.436715364515053 0.32892267422958 no 2258 0.33115889256136 3146 771486 SGTC_2361 9034121 116 µM -0.438429179168134 0.328272214414793 no 2259 0.330537599072248 3183 6496917 SGTC_109 0132-0036 33.701 µM -0.440164239285955 0.327614221046249 no 2260 0.329909079035355 3153 67274 A color developer. SGTC_1389 3405-0187 19 µM -0.442305119401626 0.32680306447295 no 2261 0.329134213443579 3213 799890 SGTC_1468 k284-1086 134 µM -0.442899576260296 0.32657797603972 no 2262 0.328919186963891 3223 15996457 SGTC_2315 7733312 200 µM -0.445834927142787 0.325467445188788 no 2263 0.327858245116673 3155 726316 SGTC_638 3970-0837 4.09 µM -0.446736769699693 0.325126561570774 no 2264 0.327532564933591 3199 4118451 YLR208W SEC13 SGTC_2239 6685329 187.64 µM -0.447072220994454 0.324999803085134 no 2265 0.327411457694952 3297 805680 SGTC_1275 0867-0008 21.1 µM -0.447256478253077 0.324930185585476 no 2266 0.327344943431432 3135 3422836 SGTC_416 estradiol valerate 100 µM -0.448670321379727 0.32439620002793 no 2267 0.326834748590516 3251 13791 A steroid. SGTC_2113 5491891 107.031 µM -0.449629522739127 0.32403413066869 no 2268 0.326488798460806 3239 789979 SGTC_44 0929-0055 61.211 µM -0.449704904425048 0.324005683421221 no 2269 0.32646161726188 3146 1379590 SGTC_637 1181-0519 7.26 µM -0.450569031312602 0.323679656028793 no 2270 0.326150095431988 3261 6252091 YGR060W ERG25 SGTC_2173 5763948 167 µM -0.45074647889586 0.323612723366341 no 2271 0.32608613974074 3260 2867177 SGTC_3074 9116018 49.47 µM -0.450932605032646 0.323542523312302 no 2272 0.326019061620226 3160 17027303 SGTC_2450 5739737 12.93 µM -0.451039480174764 0.323502216708091 no 2273 0.325980547361929 3283 2262825 SGTC_2627 acetyl isogambogic acid 100 µM -0.451372760302632 0.323376537635045 no 2274 0.325860456175297 3282 6857789 A caspase activator and apoptosis inducer. SGTC_1481 3346-2004 36 µM -0.451654249766987 0.323270404383178 no 2275 0.325759040845452 3287 2770522 SGTC_3177 9107506 49.47 µM -0.451673482415799 0.323263153398345 no 2276 0.325752112156321 3261 8897194 SGTC_1826 st055655 41.6 µM -0.451739317201421 0.323238333246879 no 2277 0.325728395194369 3257 676168 SGTC_3138 9097216 49.47 µM -0.452069320633341 0.323113931619449 no 2278 0.325609522186727 3272 25237486 SGTC_3133 9127736 49.47 µM -0.453221345050622 0.322679807294231 no 2279 0.325194681914168 3360 27243420 SGTC_1879 gemcitabine 100 µM -0.453292019265218 0.322653182561905 no 2280 0.325169239402891 3205 60750 A nucleoside analog which inhibits DNA replication. SGTC_944 3370-0224 231 µM -0.454043036744942 0.322370311811954 no 2281 0.324898925668971 3218 4580514 SGTC_1473 k844-0725 134 µM -0.454661943941645 0.322137277672367 no 2282 0.324676231654172 3280 54682906 SGTC_531 3788-1495 174 µM -0.458333907419723 0.320756131222407 no 2283 0.323356283616212 3140 2896655 SGTC_2496 diffractaic acid 79.83 µM -0.458646692838017 0.320638596561774 no 2284 0.323243950110434 3412 94870 An apoptosis inducer which activates caspases. SGTC_2495 cafestol 54.53 µM -0.459207844670437 0.320427778893474 no 2285 0.323042458881341 3349 16667697 An anti-infammatory. SGTC_384 k007-0144 5.16 µM -0.459988251720167 0.32013468611895 no 2286 0.322762326605309 3237 6824886 SGTC_3171 9103192 49.47 µM -0.461630946940431 0.319518115786769 no 2287 0.32217299900077 3332 13018434 SGTC_2078 5212016 200 µM -0.464215897779054 0.318548888634441 no 2288 0.32124653613076 3255 1899708 SGTC_1915 st067105 30.6 µM -0.46447961323543 0.318450078154714 no 2289 0.321152081204433 3298 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_86 0417-1630 471.922 µM -0.464617959054331 0.318398247081617 no 2290 0.321102534528996 3303 3634867 SGTC_639 0833-0042 114 µM -0.465187579694197 0.318184876937694 no 2291 0.320898566194472 3212 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1959 st077091 55.8 µM -0.46585801304476 0.317933821354669 no 2292 0.320658568333581 3172 821356 YKL052C ASK1 SGTC_2870 9038528 12.99 µM -0.467409496246469 0.317353162069271 no 2293 0.320103464871492 3326 6463316 SGTC_710 3448-4187 58 µM -0.46793510106045 0.317156550610849 no 2294 0.319915500506962 3298 3946412 SGTC_423 5-fluorouracil 457 µM -0.468300718894478 0.317019815441432 no 2295 0.319784777204794 3113 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_386 1509-0011 3.07 µM -0.469715214183499 0.316491052457987 no 2296 0.319279248295831 3252 3107280 SGTC_857 0438-0306 1.35 µM -0.470386234038655 0.316240344571628 no 2297 0.319039548728237 3323 4686136 SGTC_2307 7538926 6.34 µM -0.470723128978673 0.316114504993493 no 2298 0.31891923271319 3255 96582 SGTC_2140 5586273 200 µM -0.4715565412764 0.315803293990392 no 2299 0.318621676384521 3311 854421 SGTC_1607 st000305 50.6 µM -0.472242216717552 0.315547348423557 no 2300 0.31837695476014 3333 5457690 SGTC_234 nsc-17383 10.7 µM -0.475257645919836 0.314422815017018 no 2301 0.317301671795411 3373 408974 SGTC_2313 7726885 200 µM -0.475399590273939 0.314369922513041 no 2302 0.317251093227533 3317 726423 SGTC_393 acivicin 6.25 µM -0.475883023410693 0.314189810170739 no 2303 0.317078858688302 3183 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1567 st069303 68.4 µM -0.476157692390054 0.314087496648158 no 2304 0.316981018987337 3322 5581319 SGTC_1917 st066507 28.5 µM -0.47766811100765 0.313525124880953 no 2305 0.316443222314585 3196 3156428 SGTC_1665 st014639 11.4 µM -0.479489319989147 0.312847613086222 no 2306 0.31579528211865 3343 981133 YIL048W NEO1 SGTC_3081 9117243 49.47 µM -0.480641924507943 0.3124191564679 no 2307 0.315385506645643 3384 45595589 SGTC_2677 mitomycin C 100 µM -0.480657486296047 0.312413373431678 no 2308 0.315379975650095 3297 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_717 1532-0246 73.2 µM -0.481155839569913 0.312228200961073 no 2309 0.31520287201674 3295 9561992 SGTC_465 cgp-37157 41 µM -0.48257577915953 0.31170085604743 no 2310 0.314698490136354 3278 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2928 9011484 9.79 µM -0.48274678932452 0.311637371375503 no 2311 0.314637768292002 3331 2994751 SGTC_2070 5230947 200 µM -0.483381533501048 0.311401782150971 no 2312 0.314412428824868 3370 2835538 SGTC_1213 1315-0166 115 µM -0.483600547313666 0.311320511732418 no 2313 0.314334693135749 3298 768401 SGTC_3118 9124250 49.47 µM -0.484856371327131 0.310854685215967 no 2314 0.31388911615128 3255 1504786 SGTC_113 0099-0221 2.5 µM -0.485606296222306 0.31057665777995 no 2315 0.31362316576145 3408 89219 SGTC_1129 3453-1384 223 µM -0.486940787231713 0.310082175644642 no 2316 0.313150146711121 3405 1084452 SGTC_489 paxilline 115 µM -0.488016910417339 0.309683679036003 no 2317 0.312768931591226 3320 105008 A toxic potassium channel blocker. SGTC_2532 xanthone 78.9 µM -0.488461985489445 0.309518929681365 no 2318 0.312611322864181 3324 7020 An insecticide. SGTC_716 1683-5115 658 µM -0.488489639293955 0.30950869458887 no 2319 0.312601531307307 3375 723597 SGTC_2067 5224629 34.075 µM -0.489407174145764 0.309169184840274 no 2320 0.312276728993284 3386 2835000 SGTC_1046 2001-0062 216 µM -0.489481710470492 0.309141611775346 no 2321 0.312250349943604 3275 739778 SGTC_331 k048-0133 24.5 µM -0.490739902839429 0.308676333675571 no 2322 0.31180521011369 3262 6813582 SGTC_103 0844-0104 51.839 µM -0.491501538362173 0.308394830831218 no 2323 0.311535882161005 3374 5375804 SGTC_2105 5350118 200 µM -0.492719270956226 0.307944987110078 no 2324 0.311105479593665 3308 2133313 SGTC_2451 5856223 45.7 µM -0.492778859193454 0.307922981961832 no 2325 0.311084424998398 3277 2179896 SGTC_227 fluconazole 33.516 µM -0.493305935449206 0.307728369749694 no 2326 0.310898217563971 3305 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1162 k048-0130 20.1 µM -0.493363098802906 0.307707266591297 no 2327 0.310878025593635 3265 6797406 SGTC_487 nimodipine 119 µM -0.493965464372139 0.307484928259965 no 2328 0.310665284955425 3275 4497 L-type voltage-gated calcium channels inhibitor SGTC_1715 st032160 10.2275 µM -0.49427444662587 0.307370907676428 no 2329 0.310556184611793 3330 5289825 SGTC_35 0133-0054 64.071 µM -0.494311099908628 0.307357383122522 no 2330 0.310543243595968 3289 99677 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.495422617040064 0.306947373177222 no 2331 0.310150916480399 3355 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_617 3770-0098 35 µM -0.49623000783962 0.306649698857036 no 2332 0.309866070847818 3290 5962639 SGTC_612 0302-0167 22.4 µM -0.4983592143159 0.305865300368769 no 2333 0.309115439235069 3318 235821 SGTC_370 0180-0345 38.7 µM -0.49848608533784 0.305818589205744 no 2334 0.309070737161348 3221 3989527 SGTC_3308 9128332 17.569 µM -0.498487696694386 0.305817995959469 no 2335 0.309070169429872 3397 17332805 YDL196W YDL196W SGTC_1456 k015-0012 13 µM -0.499600751538347 0.305408329107269 no 2336 0.308678114293042 3439 2989616 SGTC_2059 5238311 157 µM -0.499879061299478 0.305305933489743 no 2337 0.308580118336369 3234 703021 SGTC_3301 9125354 19.7965 µM -0.500250572167449 0.305169271097628 no 2338 0.308449326480898 3348 41905162 SGTC_3059 1327-0034 3 µM -0.501440103330311 0.304731878045641 no 2339 0.308030710944635 3284 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2747 doxorubicin 7.63 µM -0.502182932529954 0.304458879673451 no 2340 0.307769423743777 3264 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_711 k292-0785 179 µM -0.502764066771611 0.304245381995013 no 2341 0.307565080033518 3306 4146315 SGTC_2932 9016711 44.54 µM -0.504363802092023 0.303658014378617 no 2342 0.307002875040878 3387 7117328 SGTC_1411 3909-8223 150 µM -0.505548198155766 0.30322347139981 no 2343 0.306586927389203 3377 X1411 SGTC_1028 k015-0029 4.8 µM -0.50626001870835 0.302962445448736 no 2344 0.30633706312821 3328 4588309 SGTC_158 k038-0087 26.446 µM -0.506998588562847 0.302691716833273 no 2345 0.306077904455139 3248 X158 SGTC_1408 3909-7976 48.8 µM -0.507782904053487 0.302404338513482 no 2346 0.305802800205899 3338 24152374 SGTC_120 rhodamine 6G 52.259 µM -0.507886838242142 0.302366265531281 no 2347 0.305766352765427 3263 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1963 st076565 50.3 µM -0.508835664732584 0.302018792599165 no 2348 0.305433709112468 3288 4914280 SGTC_1166 k206-0078 225 µM -0.509532869519473 0.301763581258128 no 2349 0.305189382398248 3353 5404595 SGTC_1707 st032323 6.317 µM -0.510477225331383 0.301418055131205 no 2350 0.304858583087477 3350 3132057 YMR211W DML1 SGTC_349 k015-0014 24 µM -0.51120838495264 0.301150656784797 no 2351 0.304602573969588 3237 2196908 SGTC_97 0535-0701 19.132 µM -0.511963314279845 0.300874677631253 no 2352 0.304338342486981 3352 2832013 YGL099W LSG1 SGTC_2426 5582046 32.21 µM -0.512456859316248 0.300694314294642 no 2353 0.304165652848405 3430 2251934 SGTC_346 4513-0042 7.16 µM -0.513234562973629 0.300410205816377 no 2354 0.303893625764367 3326 2827372 SGTC_2469 5655019 90.81 µM -0.513761630893919 0.300217727844945 no 2355 0.303709328369049 3421 2788239 SGTC_154 3389-1638 511.116 µM -0.514910593737715 0.299798335755875 no 2356 0.303307748858475 3328 5238686 SGTC_2502 avocadyne acetate 18.59 µM -0.516559285456133 0.299196997564186 no 2357 0.302731921739971 3294 3952079 SGTC_1180 1193-0155 285 µM -0.516737445051377 0.299132049023931 no 2358 0.302669726501168 3394 2921347 SGTC_1934 st074720 32.6 µM -0.517187958828027 0.298967841622678 no 2359 0.302512478387402 3319 17250992 SGTC_136 0097-0015 404.482 µM -0.518302781519478 0.298561676912854 no 2360 0.302123516273677 3407 4861337 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.51921506633849 0.298229489921681 no 2361 0.301805386856024 3336 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_16 erodoxin 22.806 µM -0.520044731330113 0.297927533213137 no 2362 0.301516199194637 3426 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_268 camptothecin 39.6153 µM -0.520696947939329 0.297690256770104 no 2363 0.301288950434301 3407 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_104 0074-0074 590.992 µM -0.521892275848101 0.29725562037799 no 2364 0.300872668309666 3309 3943124 SGTC_734 2023-0417 80 µM -0.521956573921572 0.297232249004247 no 2365 0.300850283365818 3385 3935732 SGTC_2330 7979373 200 µM -0.522295915560844 0.297108917383695 no 2366 0.300732156292099 3306 1863007 SGTC_287 k060-0039 29.6 µM -0.522327334596503 0.29709749951308 no 2367 0.300721220176276 3425 5861974 SGTC_2128 5255449 168.493 µM -0.52237914329711 0.29707867235115 no 2368 0.30070318736199 3329 736008 SGTC_2283 7944793 200 µM -0.523272728956129 0.296754031283992 no 2369 0.300392237973191 3375 2970533 SGTC_288 1315-0019 35.1 µM -0.524697884060553 0.296236606570534 no 2370 0.299896614239865 3429 6811474 SGTC_2379 9035213 200 µM -0.526478673395342 0.295590645553974 no 2371 0.299277832974 3426 646551 SGTC_1390 3413-2614 145 µM -0.526652606487648 0.295527588036788 no 2372 0.299217426488344 3374 3421432 SGTC_1198 1612-1005 86.7 µM -0.526653387564863 0.295527304879842 no 2373 0.299217155234849 3490 6998509 SGTC_459 nigericin 15.3 µM -0.526772406331075 0.295484159527538 no 2374 0.299175823549382 3446 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2420 aureobasidin a 50 nM -0.527825709823698 0.29510245405128 no 2375 0.298810155492736 3506 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_594 1487-1584 10.8 µM -0.528890580732728 0.294716787669438 no 2376 0.298440678258361 3302 5013332 SGTC_1307 1187-1599 12.2 µM -0.529104764297477 0.294639244474526 no 2377 0.29836638831259 3303 1538471 SGTC_764 1951-2361 146 µM -0.529216946590532 0.294598633660343 no 2378 0.298327481046362 3315 5438930 SGTC_1410 3909-8106 77.9 µM -0.529733987084312 0.294411494591383 no 2379 0.298148189986191 3408 1039210 SGTC_580 1123-0028 41 µM -0.530204412306335 0.29424127528025 no 2380 0.297985106085385 3438 1677248 YPR107C YTH1 SGTC_2993 9054257 71.4286 µM -0.531560940188681 0.293750682103383 no 2381 0.297515061811383 3363 6470217 YGL055W OLE1 SGTC_2060 5238662 140 µM -0.531698585182934 0.293700923456322 no 2382 0.297467385997201 3365 790130 SGTC_1152 3909-8331 15.9 µM -0.533365734066017 0.29309855935791 no 2383 0.296890216301043 3336 16001939 SGTC_948 3448-0295 75.3 µM -0.534161135504288 0.292811371789187 no 2384 0.296615027699388 3425 678569 SGTC_2605 digitonin 300 nM -0.534612007768002 0.29264863792979 no 2385 0.296459089304118 3504 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_888 0916-0002 6.97 µM -0.534631256826034 0.292641691279725 no 2386 0.296452432673468 3470 2802138 YIL048W NEO1 SGTC_2475 5812728 15.03 µM -0.535503755563136 0.292326902125589 no 2387 0.296150780674184 3387 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1171 0368-0077 21.4 µM -0.538807138916987 0.291136502332288 no 2388 0.295009968596043 3341 3239779 SGTC_1350 1495-0454 146 µM -0.539492910759629 0.290889663171006 no 2389 0.294773393648713 3466 1069057 SGTC_258 haloperidol 50.781 µM -0.54063133904602 0.290480109349085 no 2390 0.294380856266838 3378 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_230 MPP+ 141.667 µM -0.540745353360832 0.29043910714688 no 2391 0.294341556698636 3402 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3062 9077494 49.47 µM -0.541197852749125 0.290276404550887 no 2392 0.294185608680537 3412 16459633 SGTC_550 4123-0385 25.7 µM -0.541689824553688 0.290099557540105 no 2393 0.294016100336747 3350 5731123 SGTC_1145 3546-0597 10.2 µM -0.541876945002058 0.290032307406652 no 2394 0.293951640047334 3362 875334 SGTC_1242 0402-0103 60.1 µM -0.542430875785257 0.28983327036306 no 2395 0.293760857217351 3380 432868 SGTC_1682 st012968 530 nM -0.54403637862758 0.289256747325714 no 2396 0.293208219708005 3308 24207270 SGTC_3029 9088683 49.47 µM -0.544680204802543 0.28902570608738 no 2397 0.292986740823636 3441 25236615 SGTC_1345 1488-0192 31.4 µM -0.544693408564485 0.289020968739494 no 2398 0.292982199486951 3466 658348 SGTC_2277 7947813 106.88 µM -0.545027837291694 0.288900991993493 no 2399 0.292867186080597 3507 1246798 SGTC_383 2324-0395 7.37 µM -0.546314661303168 0.288439560924587 no 2400 0.292424829934861 3455 3146421 SGTC_424 splitomicin 100 mM -0.5478355398387 0.287894650596145 no 2401 0.291902416525076 3402 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3319 9138450 16.7555 µM -0.547937739929484 0.287858051115274 no 2402 0.291867326947632 3343 2029690 SGTC_1341 1486-1360 280 µM -0.548676983562882 0.287593381646975 no 2403 0.291613572130017 3338 3976547 SGTC_2657 nystatin 74.44 µM -0.54881715562698 0.287543209185661 no 2404 0.291565467881967 3439 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1252 0493-0875 34.8 µM -0.549370549424142 0.287345170711232 no 2405 0.291375590351634 3373 3960963 SGTC_402 epigallocatechin gallate 10 µM -0.549764509206963 0.287204226904776 no 2406 0.291240452138234 3359 65064 An antioxidant. SGTC_2864 9034755 47.6 µM -0.549831914129654 0.287180115269276 no 2407 0.291217333469023 3459 4930451 SGTC_2922 7999257 32.47 µM -0.550351682649389 0.28699421936159 no 2408 0.291039091050826 3454 2988377 SGTC_2641 levomentholum 100 µM -0.550641246253614 0.286890681278291 no 2409 0.290939814116409 3406 16666 SGTC_2186 6124449 200 µM -0.550786190440817 0.286838860821248 no 2410 0.290890125919464 3434 3834182 YLR033W RSC58 SGTC_1217 1183-1422 255 µM -0.551989429446125 0.286408850072971 no 2411 0.29047779775954 3453 2849664 SGTC_1444 4112-3581 28 µM -0.552620940885768 0.286183284482637 no 2412 0.290261499777573 3453 2877249 SGTC_1750 st081859 2.357 µM -0.553138569479561 0.285998458936107 no 2413 0.290084263909777 3479 5291695 SGTC_1320 1313-0481 95.3 µM -0.554114963957511 0.285649979997137 no 2414 0.289750084894319 3493 6813365 YLR208W SEC13 SGTC_1740 st038286 13.222 µM -0.554905073856335 0.285368134718613 no 2415 0.289479795607938 3476 716786 SGTC_491 tetrandrine 80.3 µM -0.55603120237977 0.284966655101446 no 2416 0.289094762260289 3446 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_751 0833-0568 350 µM -0.556671723751307 0.284738421061769 no 2417 0.288875869820313 3437 6954252 SGTC_2760 etidronate 98.04 µM -0.557325082942228 0.284505702504163 no 2418 0.288652670567124 3383 3305 A chelator and antioxidant. SGTC_2954 9074818 52.69 µM -0.557442829162185 0.284463772403524 no 2419 0.288612454980024 3461 16648742 SGTC_778 3456-2434 196 µM -0.557734324539574 0.284359981939077 no 2420 0.288512907660772 3459 5539063 SGTC_530 4358-1714 28 µM -0.558747010001104 0.283999543713593 no 2421 0.288167195656738 3445 1564641 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.5597033534579 0.283659359730419 no 2422 0.287840897305192 3416 65057 A dermal irritant. YDR527W RBA50 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.561103622545707 0.283161617945514 no 2423 0.287363449388595 3366 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_336 4111-0029 111 µM -0.561414001182295 0.283051347045207 no 2424 0.287257670739188 3402 3131175 SGTC_2215 7188065 200 µM -0.56266025086496 0.282608788799882 no 2425 0.28683312802474 3477 940217 SGTC_825 1988-2224 89.6 µM -0.564208942173463 0.282059293799516 no 2426 0.286305971422426 3387 1180859 SGTC_311 1315-0136 58 µM -0.56436152756982 0.282005182451598 no 2427 0.286254058021245 3518 6759207 SGTC_1064 honokiol 6.76 µM -0.564467695614111 0.281967535035739 no 2428 0.286217939611452 3428 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_335 4077-0256 27.6 µM -0.56526777191015 0.281683904159372 no 2429 0.28594582298082 3474 3121989 SGTC_2513 baicalein 25.65 µM -0.565560967261508 0.281579999455562 no 2430 0.285846134126881 3419 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3044 9093193 49.47 µM -0.567087169050468 0.281039431710538 no 2431 0.285327479935692 3452 25236277 SGTC_990 3985-0011 41.3 µM -0.568222888869546 0.280637495031192 no 2432 0.284941815657599 3389 5399565 YGL099W LSG1 SGTC_1488 4013-0813 75.9 µM -0.570178355535308 0.279946098360932 no 2433 0.284278367422641 3398 2910057 SGTC_1366 1683-0113 21.9 µM -0.570300979255049 0.279902769682325 no 2434 0.284236788419626 3439 708623 SGTC_2207 7258803 200 µM -0.570711226377077 0.279757833888313 no 2435 0.284097703793327 3458 3666799 SGTC_652 0437-0092 114 µM -0.571516218733801 0.279473544815014 no 2436 0.283824884733978 3476 3091274 SGTC_2764 methyldopa 94.69 µM -0.571712935199534 0.279404094260619 no 2437 0.283758234851378 3531 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_419 nsc-638432 893 µM -0.572340219196618 0.279182688268415 no 2438 0.283545753625161 3413 368090 SGTC_1856 st057054 55.7 µM -0.572940530294753 0.278970882516493 no 2439 0.283342480407276 3558 1266018 SGTC_1383 3049-0032 20.7 µM -0.57315301142857 0.278895932244177 no 2440 0.283270548253426 3510 712864 SGTC_1547 harmine 94.2 µM -0.573458492881152 0.27878819435177 no 2441 0.283167147651174 3511 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3206 9114350 49.47 µM -0.574224257650146 0.278518211761055 no 2442 0.282908028105656 3446 17087243 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.577896836978613 0.277225158381406 no 2443 0.28166688546003 3567 6710655 SGTC_2376 9072922 81.32 µM -0.578689269661726 0.276946541825567 no 2444 0.281399428787512 3520 17087968 SGTC_2560 caryophyllene 100 µM -0.581616152753195 0.275918649908103 no 2445 0.280412630163455 3457 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2233 sulbentine 40.3845 µM -0.581669306189235 0.275900000294985 no 2446 0.280394724982943 3463 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_33 0986-0033 35.816 µM -0.581837204394186 0.275841094971227 no 2447 0.280338170701308 3454 2848082 SGTC_1942 st076330 65.2 µM -0.582111958246077 0.275744713796503 no 2448 0.280245635431148 3555 24208414 SGTC_577 r071-0003 38.6 µM -0.582613561610413 0.275568798560456 no 2449 0.280076736927514 3478 4568517 YMR134W ERG29 SGTC_2068 5226020 147 µM -0.583008096350887 0.275430471704723 no 2450 0.279943924949379 3462 1810509 SGTC_871 0574-0004 149 µM -0.58436418204641 0.274955278493321 no 2451 0.279487659700964 3374 9551173 SGTC_2360 9040895 200 µM -0.585803987749554 0.27445119103937 no 2452 0.279003621819142 3431 4914414 SGTC_1594 piperine 70.1 µM -0.587352433949574 0.273909577177209 no 2453 0.278483516328268 3483 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_231 b-estradiol 524 µM -0.590599259986822 0.272775624160625 no 2454 0.277394480415675 3424 450 A steroid. SGTC_665 3914-0008 307 µM -0.590623442583072 0.27276718714187 no 2455 0.27738637701513 3442 1069549 SGTC_3003 9075612 71.4286 µM -0.591392233392729 0.272499032721466 no 2456 0.277128821517429 3502 6501993 SGTC_2289 7946404 165.07 µM -0.59168333163161 0.272397531761935 no 2457 0.277031330154252 3491 1246120 YPR165W RHO1 SGTC_6 0844-0013 19.835 µM -0.592925082176573 0.271964765682541 no 2458 0.276615645603486 3582 1584900 SGTC_1759 st043059 70 µM -0.593366983333354 0.271810839974316 no 2459 0.27646778993525 3417 669426 SGTC_3236 9132701 49.47 µM -0.594748056202334 0.271330055876386 no 2460 0.276005946862337 3466 24282524 SGTC_1761 st044296 37 µM -0.595230592779734 0.271162173455645 no 2461 0.275844671692036 3497 1826700 SGTC_1465 k213-0056 144 µM -0.595369386810619 0.271113894320117 no 2462 0.275798292010316 3429 24048857 YMR208W ERG12 SGTC_2996 9066192 71.4286 µM -0.595670819257737 0.271009056609476 no 2463 0.27569757796137 3468 6472854 SGTC_2692 st077426 47.7 µM -0.595807458977219 0.270961540201539 no 2464 0.275651930107994 3519 25238571 SGTC_811 0416-0114 265 µM -0.59608531841778 0.27086492751424 no 2465 0.27555911580157 3525 6612453 SGTC_1950 st077106 7.18 µM -0.596493576596035 0.270723005930005 no 2466 0.27542277186021 3457 13831864 SGTC_1534 6-azauridine 81.6 µM -0.596527052923004 0.270711370300615 no 2467 0.275411593411299 3495 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2974 9094440 9.66 µM -0.596896479433335 0.270582982417353 no 2468 0.275288248963734 3548 25236134 SGTC_1739 st037196 92.5 µM -0.597532279496241 0.270362092190006 no 2469 0.275076031165843 3532 612214 SGTC_2172 5754775 163.918 µM -0.598164198541395 0.270142639657591 no 2470 0.274865188648714 3411 2263357 SGTC_1611 st001856 99.4 µM -0.600165191105117 0.269448324241635 no 2471 0.27419807473775 3462 647478 SGTC_979 1426-2828 121 µM -0.600215174085368 0.269430992329901 no 2472 0.274181421079757 3555 747872 SGTC_3320 9137005 35.139 µM -0.600896957247283 0.269194635561124 no 2473 0.273954309980159 3475 4908713 SGTC_1256 0570-0116 285 µM -0.60357419203766 0.268267514112748 no 2474 0.273063387715171 3474 410638 SGTC_708 3448-5400 146 µM -0.604853126385953 0.267825189190467 no 2475 0.27263829520327 3523 3462195 SGTC_1030 k029-0042 36.7 µM -0.605993283579497 0.267431170944651 no 2476 0.272259606605768 3468 6080581 SGTC_301 4119-0100 24.5 µM -0.606951082590184 0.267100398590225 no 2477 0.271941688079513 3510 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1313 1220-0047 237 µM -0.608247872028719 0.266652886528617 no 2478 0.271511544230076 3521 3528706 SGTC_1278 0874-0585 172 µM -0.608680157566324 0.266503792400342 no 2479 0.27136823086888 3513 766306 SGTC_1112 tnp00069 1.16933 µM -0.609413694389839 0.266250894022083 no 2480 0.271125131527401 3534 145826 SGTC_2049 5262831 67.185 µM -0.609735913916161 0.266139842175936 no 2481 0.271018380015485 3521 763417 SGTC_583 1488-1091 88.9 µM -0.611212745610863 0.265631157505335 no 2482 0.270529373271188 3590 4303273 SGTC_3215 9129942 49.47 µM -0.614670966406095 0.264441929004047 no 2483 0.269386018717904 3501 17682944 SGTC_807 1315-0151 48 µM -0.61700493349904 0.263640848230245 no 2484 0.268615735818379 3607 4011080 SGTC_2756 carbadox 75.1 µM -0.617214483866722 0.263568985477691 no 2485 0.268546631764328 3517 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1025 k007-0731 70 µM -0.617320446413256 0.263532650715221 no 2486 0.268511691579246 3488 6256118 SGTC_1778 st046819 58.9 µM -0.618099335169961 0.263265646727596 no 2487 0.268254930261264 3530 671715 SGTC_3237 9133362 49.47 µM -0.619034241607242 0.262945342243296 no 2488 0.267946900789585 3521 43845137 SGTC_1944 st076371 56.9 µM -0.619046173201246 0.262941255696377 no 2489 0.267942970764072 3445 24208455 SGTC_1982 st072467 71.9 µM -0.61921031155264 0.262885041937309 no 2490 0.267888909860546 3480 3163533 SGTC_440 fluspirilene 35.1 µM -0.619227986814881 0.262878988916993 no 2491 0.267883088631953 3638 3396 An atypical antipsychotic. SGTC_661 1304-0007 33.6 µM -0.619947475752736 0.26263265527704 no 2492 0.267646183890256 3534 3117130 SGTC_1040 k898-0338 155 µM -0.620709212869626 0.262371985780429 no 2493 0.267395483307482 3602 20969351 SGTC_2912 7964298 10.93 µM -0.623257492322429 0.261500918337863 no 2494 0.266557663256205 3562 2975850 SGTC_2617 dihydrotanshinone i 20.83 µM -0.623397426917405 0.261453128135892 no 2495 0.266511694220175 3559 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2777 climbazole 1.536 µM -0.624042183930533 0.26123298987336 no 2496 0.266299940949284 3524 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2664 lyso-paf C-16 73.48 µM -0.624076616668535 0.261221236243088 no 2497 0.266288634829001 3551 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2685 mycophenolic acid 18.85 µM -0.626440798539889 0.2604148720676 no 2498 0.265512928188171 3512 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_832 4083-0019 164 µM -0.627240091221452 0.260142543313269 no 2499 0.265250933516218 3638 1990758 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.628301061043476 0.259781284859045 no 2500 0.264903368346735 3603 368090 SGTC_415 dibenzyl ketone 100 µM -0.628367116673137 0.259758801590794 no 2501 0.264881736710931 3530 7593 SGTC_2335 9018011 154.17 µM -0.629051470805287 0.259525927976485 no 2502 0.264657679978923 3561 6458208 SGTC_2193 5925765 200 µM -0.630198337378552 0.259135911417146 no 2503 0.264282413472464 3577 877370 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.630984885045998 0.258868604301859 no 2504 0.264025203725286 3537 4174840 SGTC_2828 7998861 71.43 µM -0.631985641513372 0.258528704977972 no 2505 0.263698129843613 3502 2988188 SGTC_849 0386-0493 241 µM -0.63260573436977 0.258318211194101 no 2506 0.263495570727798 3499 726119 SGTC_291 SEC14.278 35.5 µM -0.632739527140122 0.258272806185527 no 2507 0.263451876489334 3580 1068044 SGTC_290 2043-6722 48.1 µM -0.63279250661426 0.258254827781305 no 2508 0.263434575397543 3565 773758 YLR208W SEC13 SGTC_385 1494-0393 12.4 µM -0.632846017465491 0.258236669714549 no 2509 0.263417101366863 3551 3090647 SGTC_2130 NSC 7 2.4545 µM -0.633022324655541 0.258176847321755 no 2510 0.26335953223579 3565 21448 SGTC_3285 9112818 20.8695 µM -0.633250197201175 0.258099539050302 no 2511 0.263285135120707 3607 17017947 YPR165W RHO1 SGTC_41 0478-0632 82.643 µM -0.63326440508281 0.258094719267524 no 2512 0.263280496806803 3596 3750424 SGTC_1519 esterone 74 µM -0.635727888934987 0.25725973033429 no 2513 0.262476897747306 3516 698 A steroid. SGTC_822 1487-0950 154 µM -0.635846292208904 0.257219633369735 no 2514 0.262438305738566 3586 1958375 SGTC_879 0831-1030 162 µM -0.635847690403013 0.257219159894303 no 2515 0.262437850032719 3597 1549252 SGTC_1026 k007-1105 30.6 µM -0.636483912400302 0.257003760801172 no 2516 0.262230531679917 3572 7066794 SGTC_937 3122-0005 46.7 µM -0.636498242282322 0.256998910362147 no 2517 0.262225863132257 3575 759535 SGTC_1446 4239-0190 62 µM -0.637812082137307 0.256554398715666 no 2518 0.261798006833191 3568 1340085 SGTC_430 0958-0115 16.4 µM -0.638581023378576 0.256294428601072 no 2519 0.261547764798187 3523 6833180 SGTC_2452 5863136 48.41 µM -0.63865846365975 0.256268254553272 no 2520 0.261522569662387 3560 2184096 SGTC_2477 5967686 25.23 µM -0.639035715891277 0.256140766967932 no 2521 0.26139984876205 3572 776118 SGTC_1237 0330-0133 46.1 µM -0.639512233107598 0.255979781331221 no 2522 0.261244879047599 3536 X1237 YHR072W ERG7 SGTC_3114 9122766 49.47 µM -0.642899498359875 0.254836957425011 no 2523 0.260144657474354 3535 17176985 SGTC_2669 eugenol 100 µM -0.64420826711969 0.254396110440497 no 2524 0.259720195373946 3554 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2396 5342950 42.78 µM -0.644392139623088 0.254334206678866 no 2525 0.259660590181548 3571 1886677 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.644482356208677 0.254303836640277 no 2526 0.259631347624856 3666 688664 SGTC_2779 methotrexate 400 µM -0.644870717178887 0.254173122548576 no 2527 0.259505484779222 3643 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_923 1900-2434 73.3 µM -0.647914965955386 0.253149714664817 no 2528 0.258519975214833 3583 5910570 SGTC_2010 4012422 159 µM -0.648620768216066 0.252912749709302 no 2529 0.258291764142797 3560 952393 SGTC_2391 6285546 200 µM -0.648659944436676 0.252899600166464 no 2530 0.25827910013097 3546 846083 SGTC_2587 piperic acid 92.2 µM -0.650757423084565 0.252196104780839 no 2531 0.257601544316402 3540 5370536 SGTC_2840 9008771 71.43 µM -0.650967804165789 0.252125599853822 no 2532 0.257533635154788 3558 2992978 SGTC_2688 kanamycin b 96.69 µM -0.652477601279425 0.251619927349658 no 2533 0.257046558881009 3714 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_332 4112-0506 40.9 µM -0.652608773381372 0.251576019519525 no 2534 0.257004264028988 3598 2790355 SGTC_648 0375-0473 33.3 µM -0.653105839876218 0.251409670945431 no 2535 0.256844023829054 3603 1713139 SGTC_1467 k284-1082 293 µM -0.653527619959653 0.251268563375858 no 2536 0.256708094632493 3585 3334705 SGTC_3262 9137218 49.47 µM -0.653633414735151 0.251233176042604 no 2537 0.256674005492527 3480 17650664 SGTC_2890 9046729 58.44 µM -0.653661291466363 0.251223851983285 no 2538 0.256665023458439 3520 903329 SGTC_1407 3909-7909 12.3 µM -0.653771652700112 0.251186940746954 no 2539 0.256629466076572 3620 4411780 SGTC_826 1683-5028 118 µM -0.654948035045574 0.250793668145619 no 2540 0.256250605892144 3612 722377 SGTC_631 k072-0230 41.5 µM -0.655537330785944 0.250596785207501 no 2541 0.256060929743831 3603 5773147 SGTC_779 1360-0071 233 µM -0.656054888087108 0.250423937545706 no 2542 0.255894404412537 3661 7566 SGTC_2112 5488546 200 µM -0.65626239666688 0.250354654036323 no 2543 0.255827653893645 3578 600757 SGTC_330 1488-0319 80.1 µM -0.656505559645289 0.250273479074669 no 2544 0.255749445778722 3590 6846614 SGTC_3212 9128307 49.47 µM -0.656708815550339 0.250205636978674 no 2545 0.255684082489919 3522 27243542 SGTC_1747 st037496 66.6 µM -0.657943278368728 0.249793811565622 no 2546 0.255287289839029 3625 723305 SGTC_3179 9107801 49.47 µM -0.658650867906423 0.249557917124361 no 2547 0.255059994979946 3610 4818259 SGTC_3164 9100705 49.47 µM -0.662526172335844 0.248268079668785 no 2548 0.253817033602746 3612 17174235 SGTC_2327 6189656 200 µM -0.662526795670395 0.248267872487448 no 2549 0.253816833931115 3632 5349088 SGTC_3067 9117431 49.47 µM -0.663180285994782 0.2480507188173 no 2550 0.25360754792315 3605 17150885 SGTC_2204 7233102 200 µM -0.666312654157318 0.24701124696591 no 2551 0.252605639480577 3552 2172480 SGTC_1497 4476-2978 41.3 µM -0.666773275517124 0.246858587233864 no 2552 0.252458482772532 3647 1528379 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.666793818134236 0.246851780149433 no 2553 0.252451920985827 3587 77254 SGTC_3311 9131146 2.8755 µM -0.667330126516656 0.246674102398853 no 2554 0.252280643501165 3609 4900406 YPR165W RHO1 SGTC_2096 5468907 200 µM -0.667375730431564 0.246658997085428 no 2555 0.25226608208842 3632 759785 SGTC_263 alizarin 107.927 µM -0.667947639458261 0.246469606621171 no 2556 0.252083508132114 3627 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1461 k072-0203 53.8 µM -0.670481946861687 0.245631296880474 no 2557 0.251275305536372 3574 5418714 SGTC_3245 9134821 49.47 µM -0.670545043017481 0.245610445202135 no 2558 0.251255201368738 3594 17014901 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.671467282824083 0.245305776881824 no 2559 0.250961447541098 3578 279621 SGTC_2345 9052315 157.45 µM -0.671695520628071 0.245230408311093 no 2560 0.250888776805909 3622 6469265 SGTC_1667 st014849 34.6 µM -0.67179940042061 0.245196109302472 no 2561 0.250855705251454 3664 5348460 SGTC_2421 5690543 90.72 µM -0.673446453455448 0.244652630513608 no 2562 0.250331651879236 3639 3397993 SGTC_2891 9063876 19.48 µM -0.674646731822482 0.244256983135181 no 2563 0.249950117557878 3598 6472478 SGTC_1558 st069300 45.6 µM -0.67533116109685 0.244031529442304 no 2564 0.249732695217264 3590 24208000 SGTC_3326 9140064 16.379 µM -0.676141889093987 0.243764617751865 no 2565 0.249475281616662 3622 1868434 SGTC_2472 5377652 49.4 µM -0.678723883396711 0.242915612571758 no 2566 0.248656415152058 3644 1610903 SGTC_497 capsazepine 133 µM -0.678903741452805 0.242856531738121 no 2567 0.248599427459035 3617 2733484 A calcium channel blocker. SGTC_1836 st055642 81 µM -0.68001513995451 0.242491625548375 no 2568 0.248247437276023 3626 8571 SGTC_2320 7373003 200 µM -0.680640385996241 0.242286468719915 no 2569 0.248049532939603 3645 5415828 SGTC_1102 cgs 12066b 26.1 µM -0.681466671294492 0.242015490900213 no 2570 0.247788124363661 3627 6438352 A 5-HT1B full agonist. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.683736488787618 0.241271957640959 no 2571 0.24707078890075 3681 4213774 SGTC_3254 9136651 49.47 µM -0.684788071150916 0.240927907812387 no 2572 0.246738831938143 3649 16454030 SGTC_684 1140-0066 328 µM -0.685095010668833 0.240827535688403 no 2573 0.246641984229998 3664 6813534 SGTC_731 3966-0296 387 µM -0.685742774732407 0.240615785407263 no 2574 0.246437664012062 3687 660956 SGTC_1034 k072-0165 12.7 µM -0.686297609444518 0.240434493805386 no 2575 0.246262728070027 3651 5835461 SGTC_2150 5556613 200 µM -0.687366920348401 0.240085307655565 no 2576 0.245925768866075 3660 743190 SGTC_1908 st060353 56.5 µM -0.687720848820974 0.23996979235374 no 2577 0.24581429412751 3683 4227716 SGTC_347 4534-1311 26.2 µM -0.687732076839384 0.239966128245138 no 2578 0.245810758149517 3671 2862016 SGTC_2916 7875993 68.79 µM -0.689116317096138 0.239514634393087 no 2579 0.245375036245797 3638 1299250 SGTC_3098 9119039 49.47 µM -0.689631326596873 0.23934677361068 no 2580 0.245213031006444 3680 17161528 SGTC_2127 5253358 187.912 µM -0.690165346174484 0.239172784619326 no 2581 0.245045106568551 3612 20612 SGTC_1259 0671-0132 43 µM -0.690461863798214 0.239076206023801 no 2582 0.244951892218145 3610 X1259 SGTC_2194 5927483 104.545 µM -0.693402092015378 0.238119700529978 no 2583 0.244028624882585 3681 760979 SGTC_1606 st000094 49.2 µM -0.695607293005491 0.237403690206828 no 2584 0.243337398826506 3685 1242210 SGTC_2561 acetosyringone 100 µM -0.696364246096611 0.237158186659695 no 2585 0.243100374058157 3675 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1771 st048882 4.1505 µM -0.696693648405721 0.237051394765827 no 2586 0.242997267293128 3662 4580403 SGTC_618 k072-0232 33.2 µM -0.697068195410148 0.236929999121835 no 2587 0.242880058457725 3659 5872756 YGL099W LSG1 SGTC_563 tetrahydrosecaminediol 614 µM -0.699637658411036 0.23609812421875 no 2588 0.242076809156879 3709 334274 A psychoactive constituent of the cannabis plant. SGTC_1765 st044815 90.4 µM -0.700546967192887 0.235804117457621 no 2589 0.241792892266306 3675 645695 SGTC_3205 9113483 49.47 µM -0.70291442321429 0.235039595802771 no 2590 0.241054541051005 3692 17018033 SGTC_2123 5259487 200 µM -0.702971369518103 0.235021223035529 no 2591 0.241036796013593 3661 2173474 SGTC_3086 9117350 49.47 µM -0.703615472383053 0.234813469327899 no 2592 0.240836136585851 3607 2679265 SGTC_1570 verbenone 133 µM -0.705463428912742 0.234217979553246 no 2593 0.240260941533126 3692 29025 A natural terpanoid with antifungal properties. SGTC_1458 k015-0034 6.33 µM -0.705656935106437 0.234155672064443 no 2594 0.240200754110651 3687 3598957 SGTC_1838 st055369 84.5 µM -0.705745314285336 0.234127217709873 no 2595 0.24017326772439 3664 676036 SGTC_1848 st056003 16.4 µM -0.705903597130462 0.234076262119416 no 2596 0.240124045217463 3729 146492 SGTC_3150 9097574 49.47 µM -0.706337132303468 0.233936726707559 no 2597 0.239989253411726 3662 17217476 SGTC_458 nppb 133 µM -0.706433064407974 0.233905856719343 no 2598 0.239959432430626 3719 4549 A chloride channel blocker. SGTC_796 1234-0020 70.7 µM -0.70676417001454 0.233799327599357 no 2599 0.239856522099327 3649 46495034 SGTC_1931 st074438 57.1 µM -0.707343166636862 0.233613107259938 no 2600 0.239676623085568 3656 2787313 SGTC_1326 1431-2094 10.8 µM -0.709657813206635 0.232869479046955 no 2601 0.238958179512035 3667 616278 SGTC_233 rapamycin 362 pM -0.70982601038549 0.23281549351443 no 2602 0.238906018691409 3692 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1178 0988-0033 191 µM -0.710099837597514 0.232727619237499 no 2603 0.238821113513232 3712 5392207 SGTC_337 1315-0038 354 µM -0.711856713528466 0.232164256450954 no 2604 0.238276754586766 3692 1626437 SGTC_1812 st052057 4.327 µM -0.712251265053949 0.232037843342244 no 2605 0.238154598361183 3707 3645418 SGTC_2167 5876490 200 µM -0.71267059618156 0.231903532941739 no 2606 0.238024807802673 3804 686534 SGTC_2515 chrysin 20.77 µM -0.715026398031603 0.231149782694243 no 2607 0.237296365842737 3717 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2488 5268135 45.7 µM -0.716409901543599 0.230707761967573 no 2608 0.236869141387831 3736 1270356 YLR208W SEC13 SGTC_870 0573-2213 57.6 µM -0.716652325005993 0.230630357834216 no 2609 0.236794324839938 3695 3916321 SGTC_360 0957-0399 1.01 µM -0.716914458240601 0.230546676837541 no 2610 0.236713440101932 3709 6752301 YPR165W RHO1 SGTC_3185 9108267 49.47 µM -0.71797112827823 0.230209527359386 no 2611 0.236387544486574 3670 4910486 SGTC_1425 4048-4433 7.33 µM -0.718710690563641 0.229973720933886 no 2612 0.236159597490247 3764 23734946 SGTC_3093 9117344 49.47 µM -0.720078508929126 0.229537954044292 no 2613 0.235738329389569 3728 24824913 SGTC_702 1488-0190 94 µM -0.72099706905806 0.22924557410713 no 2614 0.235455659015177 3720 949357 SGTC_1295 1013-0063 9.78 µM -0.721927301412319 0.228949691814753 no 2615 0.235169587450582 3721 6826038 SGTC_1429 4049-0205 9.46 µM -0.722256305387959 0.228845095678178 no 2616 0.235068455812752 3730 22774478 SGTC_2351 9026858 72.31 µM -0.722760649057251 0.2286848080598 no 2617 0.234913473634528 3654 1409300 SGTC_1218 1348-1416 30.7 µM -0.723104470321338 0.228575572900051 no 2618 0.234807851531038 3692 6787668 SGTC_723 4182-0001 115 µM -0.723374825545321 0.228489699159645 no 2619 0.234724816680153 3689 744821 YLR208W SEC13 SGTC_932 2857-0803 154 µM -0.723700169937836 0.22838638307802 no 2620 0.234624914400981 3799 674898 SGTC_2288 7946289 167.31 µM -0.724327865338684 0.228187126875439 no 2621 0.234432236800476 3721 1246052 SGTC_2946 9065502 71.43 µM -0.724936070351379 0.227994150986722 no 2622 0.234245625521338 3544 16489101 SGTC_644 1498-1197 63.3 µM -0.726582309310835 0.227472280607615 no 2623 0.233740934320328 3762 6741615 SGTC_477 mead ethanolamide 10 µM -0.727048569664391 0.2273245948552 no 2624 0.233598101437156 3598 16061185 SGTC_556 4058-0063 51.5 µM -0.728324287347189 0.22692079358917 no 2625 0.233207549151877 3777 6615692 SGTC_492 tmb-8 126 µM -0.728459312195168 0.226878078037289 no 2626 0.23316623343506 3610 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3231 9132313 49.47 µM -0.729630994896641 0.226507602884831 no 2627 0.232807885563454 3722 4905967 SGTC_817 1391-0715 46 µM -0.731354956533511 0.225963123785038 no 2628 0.232281185306768 3712 1353946 SGTC_106 0092-0003 11.579 µM -0.732022424653731 0.225752516086509 no 2629 0.232077440366787 3686 1072148 SGTC_3078 9116413 49.47 µM -0.73342998371902 0.225308750022943 no 2630 0.231648108626607 3668 17177322 SGTC_2221 6807166 181.081 µM -0.733894314322718 0.22516246732115 no 2631 0.231506576293334 3677 674925 SGTC_1867 st057372 64 µM -0.733919652764167 0.225154486247606 no 2632 0.231498854285564 3713 688837 SGTC_1351 1496-0003 46.5 µM -0.734007900821893 0.225126691225578 no 2633 0.23147196140091 3748 3891978 SGTC_2189 6047310 154.431 µM -0.734768267026958 0.22488728327027 no 2634 0.231240318099916 3679 711535 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.735780164371925 0.224568902486613 no 2635 0.230932247256387 3545 4000243 SGTC_3204 9114183 49.47 µM -0.738137626376396 0.223828149437759 no 2636 0.230215410562383 3752 17027248 SGTC_1661 st013063 9.66 µM -0.739137719907101 0.223514323755347 no 2637 0.229911687153795 3771 721395 SGTC_1103 duloxetine 36.1 µM -0.740809984023029 0.222990132964345 no 2638 0.229404330351303 3824 60835 A selective serotonin reuptake inhibitor. SGTC_1999 st074831 12.5 µM -0.743056552737949 0.222287023064047 no 2639 0.228723721205056 3729 17112523 SGTC_1331 1472-0049 76.2 µM -0.745254447989084 0.221600372244245 no 2640 0.228058956500705 3705 24051409 SGTC_614 0462-0418 107 µM -0.745816166920752 0.221425078696353 no 2641 0.227889236229747 3605 5188303 SGTC_655 k060-0012 42 µM -0.746585910751598 0.221184996395304 no 2642 0.22765677784168 3750 5994525 SGTC_941 3237-0776 460 µM -0.748203338914343 0.220681007758204 no 2643 0.227168758680921 3750 760008 SGTC_1727 st034309 9.9045 µM -0.748786764555801 0.220499374597055 no 2644 0.226992869164986 3797 870305 SGTC_467 ro 31-8220 72.8 µM -0.749491566341415 0.220280068685417 no 2645 0.226780489972398 3701 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3269 9137823 49.47 µM -0.750897708024137 0.219842907913231 no 2646 0.226357109908729 3697 17682936 SGTC_1945 st075991 56.6 µM -0.751289687286222 0.219721132791922 no 2647 0.226239167136204 3727 1084980 SGTC_625 k213-0058 121 µM -0.751319077917492 0.21971200364621 no 2648 0.226230325178707 3810 3655420 SGTC_1702 st027038 51 µM -0.751788967357458 0.219566078917554 no 2649 0.226088988876682 3762 5521182 SGTC_2999 9069765 71.4286 µM -0.753206113595062 0.219126319706187 no 2650 0.225663033073318 3789 2097066 SGTC_770 0389-1121 67.2 µM -0.75367283748255 0.21898160004542 no 2651 0.225522847961475 3859 6753108 SGTC_1943 st076331 65.2 µM -0.755965362486136 0.218271542802956 no 2652 0.224834981621006 3804 24208415 SGTC_1882 5615643 20 µM -0.756178446722577 0.218205612276368 no 2653 0.224771106709231 3695 2253075 SGTC_1992 st073643 23.3 µM -0.758143050567458 0.217598283872294 no 2654 0.224182674871152 3734 3161292 SGTC_1994 st072947 40.9 µM -0.758923955249841 0.217357149868275 no 2655 0.223949023995867 3814 5286565 YDL195W SEC31 SGTC_2139 5578692 56.4705 µM -0.761446264850261 0.21657934578986 no 2656 0.223195281401457 3709 650991 YMR113W FOL3 SGTC_3155 9099265 49.47 µM -0.761594246271727 0.216533762850893 no 2657 0.223151104959842 3746 25236499 SGTC_699 0375-0592 111 µM -0.761618380448871 0.216526329290633 no 2658 0.223143900729845 3789 762578 SGTC_118 0083-0097 135.343 µM -0.76220319319768 0.216346246443597 no 2659 0.222969370293671 3824 5207356 SGTC_642 0335-0876 158 µM -0.763158138488718 0.216052374199668 no 2660 0.22268454539414 3797 6812350 SGTC_91 0417-1751 58.384 µM -0.764013813079144 0.215789247774756 no 2661 0.222429505537024 3870 6795624 SGTC_2430 5571206 200 µM -0.764163050148571 0.215743375274053 no 2662 0.222385041441904 3810 1731771 SGTC_2879 9041815 71.43 µM -0.766090297133768 0.215151486017604 no 2663 0.221811287965579 3759 4942971 SGTC_501 nsc-95397 161 µM -0.766790152794568 0.214936782355066 no 2664 0.221603146022818 3787 262093 SGTC_1522 st012842 45.6 µM -0.767146670553632 0.214827456706213 no 2665 0.221497158090029 3681 3491067 YOR116C RPO31 SGTC_1004 4084-0029 199 µM -0.767328681734981 0.214771655702325 no 2666 0.221443059790057 3816 716894 YLR208W SEC13 SGTC_373 0844-0104 25.9 µM -0.76835942264477 0.214455809988302 no 2667 0.22113684023131 3831 5375804 SGTC_1298 1079-1278 263 µM -0.768709002898077 0.214348750906741 no 2668 0.221033039584179 3815 2840950 SGTC_276 colchicine 750 µM -0.768896114062836 0.214291460817238 no 2669 0.22097749224122 3838 2833 A microtubule depolymerizer. SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.769265286238277 0.214178453031671 no 2670 0.220867920222515 3816 521171 SGTC_12 0849-0099 9.267 µM -0.770429780038317 0.213822215559965 no 2671 0.220522496931028 3701 6071388 SGTC_785 1270-0111 65.3 µM -0.77043317826922 0.213821176491398 no 2672 0.220521489368467 3767 6741994 SGTC_2710 st078562 53.7235 µM -0.772631874150572 0.213149503387857 no 2673 0.219870137599394 3764 17250908 SGTC_3335 9143315 29.6265 µM -0.772813610234603 0.213094040487166 no 2674 0.219816348717206 3793 4899691 SGTC_1183 1254-0324 198 µM -0.773126775321792 0.212998487344787 no 2675 0.219723678189292 3854 5799357 SGTC_2768 sulfasalazine 50.2 µM -0.773959711668602 0.212744462952498 no 2676 0.2194773082794 3784 5384001 An antioxidant and salicylic acid derivative. SGTC_2378 9074213 121.43 µM -0.775233158800318 0.212356436090716 no 2677 0.219100948931147 3770 657714 SGTC_1817 st052116 64.4 µM -0.775460299915975 0.212287268339218 no 2678 0.219033857812867 3781 4361398 SGTC_2295 7971645 200 µM -0.776332502713819 0.212021792369902 no 2679 0.218776343370705 3837 2978226 YKL099C UTP11 SGTC_1810 st050138 53 µM -0.779890701385347 0.210940782310324 no 2680 0.21772760608892 3755 3444541 SGTC_3332 9141069 11.198 µM -0.779932069028997 0.210928233512569 no 2681 0.217715430541832 3746 17332883 SGTC_2257 7960413 200 µM -0.782208445422475 0.210238373966065 no 2682 0.217046040999767 3788 2974689 YIL048W NEO1 SGTC_1872 amphotericin b 148 nM -0.782267028105122 0.210220637895902 no 2683 0.217028829931801 3824 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2084 5306078 60.6385 µM -0.782278669066111 0.210217113667234 no 2684 0.217025410015559 3748 679340 SGTC_704 1310-0270 142 µM -0.783535919826653 0.20983669309242 no 2685 0.216656234491673 3790 5718033 SGTC_3069 9117009 49.47 µM -0.784020577736632 0.209690152806205 no 2686 0.216514017984731 3742 41904981 SGTC_3033 9090887 49.47 µM -0.784132312120463 0.209656377538565 no 2687 0.216481238658705 3845 19325384 SGTC_1132 3456-3614 2.5 µM -0.7876217707605 0.208603188822762 no 2688 0.215458988211872 3912 3125502 SGTC_3187 9109394 49.47 µM -0.788661130700382 0.208290092992245 no 2689 0.215155045773257 3787 17098090 SGTC_1694 st024011 44.9 µM -0.789812739474422 0.207943507395577 no 2690 0.214818568989365 3845 2787533 SGTC_3096 9117468 49.47 µM -0.791831590143612 0.207336740968663 no 2691 0.214229439970001 3759 41316311 SGTC_1126 isoteolin 1.0172 µM -0.792244963334115 0.207212630721438 no 2692 0.214108927896595 3786 133323 SGTC_2318 6029776 164 µM -0.792482931300814 0.207141203680308 no 2693 0.214039570192938 3798 818325 SGTC_1261 0712-0010 12.7 µM -0.792977357876832 0.206992846130903 no 2694 0.213895507354747 3797 2840123 SGTC_1001 4048-4355 44.4 µM -0.793307387408266 0.206893852529931 no 2695 0.213799376898028 3814 21824233 SGTC_978 1416-0512 87.4 µM -0.794293825658915 0.206598133751153 no 2696 0.213512198827126 3884 6814003 SGTC_565 1418-0001 44.5 µM -0.794586390778397 0.206510475455787 no 2697 0.213427068682795 3878 2862145 SGTC_73 0327-0325 16.231 µM -0.79659959464648 0.205907877452353 no 2698 0.212841806456984 3797 53298 SGTC_1240 0356-0016 42.1 µM -0.796884280539969 0.205822748707812 no 2699 0.212759120560238 3831 4305613 SGTC_800 3448-7362 155 µM -0.797506908539357 0.205636638971051 no 2700 0.212578346081307 3901 15991913 SGTC_452 diindolylmethane 8 µM -0.79796496470789 0.205499785198265 no 2701 0.212445410858018 3832 3071 Inhibits expression of several cancer promoting factors. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.79864043322474 0.205298073683486 no 2702 0.212249467738721 3833 3256 An antibiotic and ribosome inhibitor. SGTC_3217 9129673 49.47 µM -0.800268309542493 0.204812433317021 no 2703 0.211777679917706 3820 17248312 SGTC_2751 anetholtrithion 17.25 µM -0.802057362819918 0.204279498206983 no 2704 0.21125988858027 3838 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_3113 9123498 49.47 µM -0.803661356284034 0.20380239267367 no 2705 0.210796288832795 3875 8897275 SGTC_1899 st063254 59.6 µM -0.803746784798546 0.203777000729647 no 2706 0.210771614308931 3769 3093813 SGTC_919 tnp00227 403.569 nM -0.803791624278183 0.20376367383186 no 2707 0.210758663891872 3838 1269246 A methoxyflavone. YNL221C POP1 SGTC_2628 lathosterol 100 µM -0.804706765725596 0.203491794986675 no 2708 0.21049445720245 3899 6710616 SGTC_1991 st073000 8.92 µM -0.805365012403697 0.203296370727586 no 2709 0.210304537793093 3918 4301969 YIL048W NEO1 SGTC_892 0929-0076 29 µM -0.805673902371282 0.203204704227104 no 2710 0.210215450582094 3822 5751038 SGTC_2013 4024628 200 µM -0.807085768819744 0.202786031505419 no 2711 0.209808535285032 3862 5230760 SGTC_2340 7987427 183.45 µM -0.807472035524993 0.202671578416755 no 2712 0.209697289734081 3856 2239331 SGTC_1214 0358-0031 63.7 µM -0.808322495688687 0.202419718195249 no 2713 0.209452477865436 3999 4301366 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.809322574758912 0.202123788522496 no 2714 0.209164812220184 3828 688667 SGTC_2567 aureobasidin a 60 nM -0.809534283632959 0.202061175755576 no 2715 0.20910394551146 4010 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1776 st049249 45.9 µM -0.8114571336663 0.201493025714761 no 2716 0.208551600139849 3905 1822314 SGTC_277 nystatin 15.5 µM -0.811478269378991 0.201486786008389 no 2717 0.208545533616351 3824 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1698 5-fluorocytosine 1.055 µM -0.81341148103299 0.200916551081022 no 2718 0.207991089486207 3875 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_420 mitomycin C 81.9 mM -0.815311570014933 0.200357030896693 no 2719 0.207446993832369 3834 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1036 k216-0215 33.5 µM -0.817249369136035 0.199787371400439 no 2720 0.206892967262041 3850 622330 SGTC_2580 diallyl disulphide 81.36 µM -0.818237177404112 0.199497358302517 no 2721 0.206610885196516 3879 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1483 3453-0561 55.9 µM -0.818736991741637 0.199350713157791 no 2722 0.20646824325082 3874 4546991 SGTC_1985 st071382 65.5 µM -0.818751961149248 0.199346322146335 no 2723 0.206463972033669 3871 6123237 SGTC_2435 5706476 10.6 µM -0.820196319392995 0.198922919098833 no 2724 0.206052099925177 3869 5725375 SGTC_3017 9080681 49.47 µM -0.821262000324888 0.198610870288462 no 2725 0.205748523764307 3891 16451914 SGTC_1276 0871-0068 94.2 µM -0.821376560779375 0.19857734269679 no 2726 0.205715905204136 3857 3414906 SGTC_2106 5357045 167.29 µM -0.821917001287024 0.198419221869904 no 2727 0.20556206809521 3902 668842 SGTC_2531 methyl deoxycholate 70.07 µM -0.823000588177079 0.198102417483249 no 2728 0.205253829473731 3835 16667744 Haematoxylin. SGTC_933 2914-0560 114 µM -0.823529608060121 0.197947860865794 no 2729 0.205103443556847 3921 463887 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.823773340049562 0.197876677486477 no 2730 0.205034179243938 3670 88881 An O-methylated flavonoid and antioxidant. SGTC_727 3032-0951 202 µM -0.8243813859566 0.19769916148056 no 2731 0.204861443990421 3870 3652836 SGTC_1328 1441-0025 69.2 µM -0.825961912483588 0.197238184982504 no 2732 0.204412848924279 3822 4562601 SGTC_1216 1165-0504 9.65 µM -0.827135405900818 0.196896344793192 no 2733 0.204080159128583 3856 6304004 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.828516234571142 0.196494567243585 no 2734 0.20368910236254 3914 5282362 SGTC_1404 3909-7820 48.3 µM -0.829900380752158 0.196092323400186 no 2735 0.203297554803991 3829 23741373 SGTC_339 3091-4833 71.4 µM -0.832189439757987 0.195428201625843 no 2736 0.202651011825036 3802 3240077 SGTC_1139 k015-0024 46.9 µM -0.833080676880805 0.19516999808381 no 2737 0.20239961531608 3841 2766652 SGTC_601 0986-0029 62.9 µM -0.833284750983504 0.195110904220098 no 2738 0.202342077182236 3846 24747981 SGTC_1388 3346-4487 254 µM -0.835123922468747 0.194578825014908 no 2739 0.201823969316462 3954 3345614 SGTC_2011 4012611 177 µM -0.836332314597293 0.194229713797477 no 2740 0.201483989368279 3911 2049887 SGTC_210 3551-0445 56.827 µM -0.838647626904227 0.193561873713334 no 2741 0.200833537997961 3909 2865180 YOR207C RET1 SGTC_2282 7944268 200 µM -0.8403389681492 0.193074901282537 no 2742 0.200359179167047 3889 2970414 SGTC_2691 st077356 60.2 µM -0.840409347351901 0.19305465386592 no 2743 0.200339454994674 3961 2839272 SGTC_3004 9076122 71.4286 µM -0.840428489041006 0.193049147211176 no 2744 0.200334090629081 3918 44782551 SGTC_1573 oleylamine 1.06 µM -0.840930920247795 0.192904642792574 no 2745 0.200193317580446 3893 5356789 An amine of the fatty acid oleic acid. SGTC_131 0141-0277 33.849 µM -0.842058504356331 0.19258057852562 no 2746 0.199877603359003 3852 1547771 SGTC_199 4063-0024 41.6 µM -0.845059431626574 0.191719743665861 no 2747 0.199038828687628 3909 306215 SGTC_93 0109-0045 59.227 µM -0.845979924844256 0.191456167367919 no 2748 0.1987819717348 3975 88733 SGTC_904 1141-0088 396 µM -0.846833043867049 0.191212081515946 no 2749 0.198544093586195 3923 1378119 SGTC_446 go6976 132 µM -0.847762536199264 0.190946361761647 no 2750 0.198285115553589 3902 3501 A protein kinase C inhibitor. SGTC_2707 st078556 66.6 µM -0.850002605558517 0.190306910539506 no 2751 0.197661818817607 3873 17250899 SGTC_1886 st057356 49.9 µM -0.851470406137132 0.18988862572623 no 2752 0.197254047918407 3869 24207747 SGTC_2014 4013930 200 µM -0.852658805112732 0.189550377501026 no 2753 0.196924270912562 3846 64556 SGTC_2666 tannic acid 100 µM -0.854116433365887 0.189136006417133 no 2754 0.196520239698276 3912 16134267 A thiamine antagonist. SGTC_428 3448-4153 16.5 µM -0.855071642915252 0.188864764526083 no 2755 0.196255743544062 3879 3834874 SGTC_763 3453-1109 128 µM -0.855349376626537 0.188785944090062 no 2756 0.196178879996557 3946 1560353 SGTC_3125 9127534 49.47 µM -0.855707184334069 0.188684428654214 no 2757 0.196079882668711 3772 1639235 SGTC_658 3253-0951 102 µM -0.856163783577219 0.188554933449841 no 2758 0.195953595962945 3906 1184878 SGTC_3228 9131799 49.47 µM -0.858426478708754 0.187914023955065 no 2759 0.195328505826812 3919 17015818 SGTC_1676 st018489 23.4 µM -0.860317490832769 0.187379426985136 no 2760 0.194807026931824 3961 3696235 SGTC_1881 5652484 16 µM -0.863715343901692 0.186421205037397 no 2761 0.193872141253977 3878 2255129 SGTC_303 1348-1668 34.2 µM -0.864691656165827 0.18614643946562 no 2762 0.193604025155491 3925 5380509 SGTC_126 0417-1624 672.48 µM -0.866471078352847 0.18564629905232 no 2763 0.193115940015128 3980 41912 YDL195W SEC31 SGTC_1700 st030840 7.9285 µM -0.866711400365015 0.185578815948828 no 2764 0.193050078714868 3966 5499307 SGTC_2787 5284540 71.43 µM -0.866867602137267 0.185534962211066 no 2765 0.193007278289965 3970 736958 SGTC_1334 1486-0610 236 µM -0.86752048786673 0.185351733794181 no 2766 0.1928284455729 4007 3742339 SGTC_866 0495-0101 262 µM -0.868160467078302 0.185172236587768 no 2767 0.192653246373419 3876 635694 SGTC_977 1348-1378 135 µM -0.868564587007764 0.185058947289195 no 2768 0.192542665580111 3919 X977 SGTC_953 1188-0045 9.7 µM -0.869492317892216 0.184799034006918 no 2769 0.192288954046304 3971 6144426 SGTC_3043 9092303 49.47 µM -0.872491599961598 0.183960308141334 no 2770 0.191470124360103 3943 25236084 SGTC_2773 thioridazine 9.09 µM -0.873749760044979 0.183609180318762 no 2771 0.191127272907129 3953 5452 An antipsychotic. SGTC_1923 st058458 19.1 µM -0.874512953101667 0.183396391739057 no 2772 0.190919484628673 3972 3534982 SGTC_169 k015-0017 16.025 µM -0.878071694471346 0.182406197533036 no 2773 0.189952406352671 3912 1840002 SGTC_389 tpck 16.7 µM -0.878469723766147 0.182295656795451 no 2774 0.189844430528301 3949 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3055 9094636 49.47 µM -0.878880902668581 0.182181508115817 no 2775 0.189732927169115 3941 25236176 SGTC_1354 1498-1681 81 µM -0.880446804995981 0.181747202177408 no 2776 0.189308655194282 3960 5754243 SGTC_1438 4092-1045 4 µM -0.881633683564085 0.181418451094529 no 2777 0.188987466884648 3917 1351342 SGTC_2986 9022445 71.43 µM -0.881649713890823 0.181414013436476 no 2778 0.188983131120912 3952 6459286 SGTC_1562 morin hydrate 59.1 µM -0.882683422155512 0.181127996587861 no 2779 0.188703670776284 4032 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2447 5741742 33.78 µM -0.883196753141813 0.180986068010109 no 2780 0.188564987783682 4002 1776504 SGTC_253 dyclonine 31.25 µM -0.883551138964478 0.180888126139782 no 2781 0.188469282556686 4030 3180 An oral anasthetic. SGTC_2087 5276107 200 µM -0.888212982160557 0.179602823277618 no 2782 0.187213098417574 3914 144405 SGTC_3186 9110464 49.47 µM -0.889611719778103 0.179218303612468 no 2783 0.18683720551362 3970 17018021 SGTC_1863 st057641 20.1 µM -0.890809852612713 0.178889343193728 no 2784 0.186515594274151 3964 3921635 SGTC_1625 st003711 30.1 µM -0.891222548948209 0.178776120970819 no 2785 0.18640489485555 4029 24207034 YER133W GLC7 SGTC_1527 coumarin 137 µM -0.891873298270954 0.178597681169922 no 2786 0.186230424103725 4076 323 A hepatotoxic, DNA x-linker. SGTC_1190 1486-1332 13 µM -0.893241534176528 0.178222867753772 no 2787 0.185863920039991 3957 4150046 SGTC_3277 9138724 49.47 µM -0.893450176230435 0.178165756115547 no 2788 0.185808071232076 3895 15943418 SGTC_1857 st056007 79.3 µM -0.894053969949194 0.178000544526443 no 2789 0.185646507822585 3954 619834 SGTC_1457 k015-0032 57.3 µM -0.895211943809263 0.177683967123996 no 2790 0.18533690059808 3965 4302660 SGTC_584 0986-0246 15.4 µM -0.895735764839978 0.177540876949394 no 2791 0.185196952051002 4046 53315 YDR232W HEM1 SGTC_2144 5628481 200 µM -0.897360007965187 0.177097651260118 no 2792 0.184763422654431 3951 2818399 SGTC_468 gf-109203x 121 µM -0.898622765865416 0.176753551558267 no 2793 0.184426814130135 3933 2396 A protein kinase C inhibitor. SGTC_2745 rifampicin 24.3 µM -0.901194831569737 0.176053975638423 no 2794 0.183742369245445 3969 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2063 5246145 200 µM -0.901400802444917 0.175998029549262 no 2795 0.183687627457523 4015 711240 SGTC_3234 9132280 49.47 µM -0.903154429993225 0.175522162848342 no 2796 0.183221969764061 4017 17612295 SGTC_1578 josamycin 24.2 µM -0.903823586532024 0.1753407947991 no 2797 0.183044476387808 3978 5282165 A P450 substrate. SGTC_2229 7354935 190 µM -0.905053274583354 0.175007810344531 no 2798 0.182718582178496 3900 318112 SGTC_3356 9151811 4.48 µM -0.905706363498033 0.174831125106248 no 2799 0.182545646722422 3963 1859254 YPR165W RHO1 SGTC_722 3534-0461 190 µM -0.906715604762008 0.1745583099445 no 2800 0.182278604605013 4032 658262 SGTC_1474 0330-0125 5.35 µM -0.907546623736248 0.17433387438325 no 2801 0.182058902917556 3985 X1474 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.90849606447631 0.174077680829648 no 2802 0.181808096048716 4098 16725076 SGTC_247 mechlorethamine 29.705 µM -0.910389038876406 0.173567602351323 no 2803 0.181308688151445 3876 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1972 st070201 17.4 µM -0.910874126185388 0.17343704458682 no 2804 0.181180849949271 3961 2829099 SGTC_49 0717-0965 32.132 µM -0.915245966207149 0.172263216856231 no 2805 0.180031259223428 4050 5889349 YGL099W LSG1 SGTC_1772 st048439 82.2 µM -0.915877107698898 0.172094176684751 no 2806 0.179865677466618 4037 2927068 YDL195W SEC31 SGTC_1205 4161-2785 76 µM -0.917289912516014 0.171716165621637 no 2807 0.179495370971667 4086 3498106 SGTC_738 1315-0003 72.4 µM -0.918427167653458 0.171412266429987 no 2808 0.179197636464943 4051 6251474 SGTC_1610 st001799 48.1 µM -0.920438230362679 0.170875708935266 no 2809 0.178671899106691 3903 621897 SGTC_296 1222-0039 74.9 µM -0.921090053442194 0.170702031464255 no 2810 0.17850170640469 3989 5984176 SGTC_203 k066-0004 30.888 µM -0.921259922514606 0.170656788622024 no 2811 0.178457369926865 4055 6795412 SGTC_2398 5228213 48.84 µM -0.925187974429294 0.169612734788512 no 2812 0.17743406885218 4013 80771 YMR134W ERG29 SGTC_1530 rhein 70.4 µM -0.926193015991112 0.169346260179162 no 2813 0.177172840695499 4063 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_495 decylubiquinone 155 µM -0.928511817659574 0.168732483760292 no 2814 0.17657107028664 4055 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3117 9124945 49.47 µM -0.929851028564742 0.168378652720586 no 2815 0.176224110723365 3917 17592065 SGTC_2678 equilin 100 µM -0.93002235524874 0.168333421189415 no 2816 0.176179754966402 4015 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2679 rapamycin 1 nM -0.932161153981264 0.167769420089519 no 2817 0.175626623822047 3955 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_685 1278-0033 54.9 µM -0.932969030850056 0.167556699978395 no 2818 0.175417979228679 4046 3590572 SGTC_1484 3473-2379 286 µM -0.93446700145897 0.16716273291556 no 2819 0.17503152504028 4127 671917 SGTC_2205 7238770 200 µM -0.935587831278572 0.166868344986432 no 2820 0.174742721136017 4066 279867 SGTC_1280 0880-0253 10.1 µM -0.935629179252711 0.16685749126818 no 2821 0.174732072804056 4002 6836607 SGTC_432 NS 1619 61.3 µM -0.937930157462205 0.166254209326256 no 2822 0.17414015191877 4060 4552 A K+/calcium channel activator. SGTC_3242 9133940 49.47 µM -0.938102932774367 0.166208967165434 no 2823 0.174095757403852 4042 17248444 SGTC_3162 9099653 49.47 µM -0.939041200780063 0.165963415425027 no 2824 0.173854795624572 4006 25237511 SGTC_2483 5729050 27.16 µM -0.93911411241466 0.165944343727777 no 2825 0.173836079671472 4011 2865180 SGTC_691 1548-0686 185 µM -0.941459171442749 0.165331695611018 no 2826 0.173234801420001 4014 46495133 SGTC_2129 girgensonine 121.053 µM -0.941813579656301 0.165239233714373 no 2827 0.173144045715678 4036 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_273 hydroxyurea 18.1 mM -0.942945875792361 0.164944052199126 no 2828 0.172854293967951 4095 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.94392938487823 0.164687935688818 no 2829 0.172602867378197 4116 688801 SGTC_2804 7954240 19.48 µM -0.945491980133651 0.1642815489912 no 2830 0.17220388164404 4073 828705 SGTC_422 cantharidin 155 µM -0.946047085826322 0.164137338409287 no 2831 0.172062285352172 3953 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_546 peri-Naphthalide 147 µM -0.949439098724006 0.163257913788961 no 2832 0.171198666323254 3938 223824 A penicillin ester. SGTC_1140 3229-1848 2.98 µM -0.949934847038833 0.163129641311578 no 2833 0.171072679520588 4052 2849525 SGTC_860 0443-0016 25.1 µM -0.951866205265219 0.162630536562569 no 2834 0.170582420274316 4055 5337942 SGTC_264 promethazine 12.5 mM -0.955231149956072 0.161763337809265 no 2835 0.169730408208024 3938 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2603 homopterocarpin 100 µM -0.958111130543629 0.161023519617867 no 2836 0.169003361709548 4062 101795 A weak amylase inhibitor. SGTC_974 1326-0144 138 µM -0.958374723616685 0.160955917501818 no 2837 0.168936918124867 4065 5411856 SGTC_3094 9117742 49.47 µM -0.960400775350789 0.160436926813678 no 2838 0.168426774019252 3973 17149698 SGTC_3352 9151559 45.5865 µM -0.962446695939419 0.15991395733102 no 2839 0.167912633410135 4051 17159339 SGTC_842 0271-0008 11.1 µM -0.965673510270208 0.159091401441266 no 2840 0.167103789344301 4105 1221709 SGTC_3284 9108171 64.8615 µM -0.969034164834448 0.158237679869124 no 2841 0.166264071649421 4036 8687505 SGTC_1472 k841-0093 193 µM -0.974117323039791 0.15695210632969 no 2842 0.164999144595361 4161 X1472 SGTC_1077 5-fluorocytosine 377 nM -0.974819874635039 0.156774967088646 no 2843 0.1648248083665 4090 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1697 st025554 27.742 µM -0.975397899952226 0.156629324220916 no 2844 0.164681462484626 4032 1269519 SGTC_2822 7994718 71.43 µM -0.975850845281872 0.156515259549571 no 2845 0.164569191950581 4031 1018011 SGTC_3199 9111318 49.47 µM -0.976612299662951 0.156323626709856 no 2846 0.164380563787142 4018 8548020 SGTC_653 0203-0016 55.2 µM -0.977319441270097 0.156145801057125 no 2847 0.164205515607434 4105 295302 SGTC_3154 9100113 49.47 µM -0.978742219323162 0.15578841757301 no 2848 0.163853682855755 4091 25237525 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.97937802490627 0.155628885915891 no 2849 0.163696615468034 4036 2724278 An inhibitor of dopamine biosynthesis. SGTC_178 4092-0806 87.505 µM -0.979688366953396 0.155551056320106 no 2850 0.163619985065901 3967 2169044 SGTC_1201 1889-3372 45.9 µM -0.97985896928808 0.15550828249647 no 2851 0.16357786945124 3931 5392199 SGTC_1106 tegaserod maleate 11.7 µM -0.983789947296326 0.154524847750594 no 2852 0.162609401548475 4070 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1094 duloxetine 25.4 µM -0.98406184041244 0.154456979062647 no 2853 0.16254255394738 4063 60834 A selective serotonin reuptake inhibitor. SGTC_1010 4112-3296 15.2 µM -0.984171117741536 0.154429707319232 no 2854 0.162515692077642 4151 704384 SGTC_2536 dehydroabietamide 32.04 µM -0.985271974167801 0.154155150197507 no 2855 0.162245247570262 4166 3983547 SGTC_518 1021-0119 62.6 µM -0.985477969460428 0.154103810194801 no 2856 0.162194673810176 4052 1097762 SGTC_3049 9092223 49.47 µM -0.988583130267932 0.1533312844538 no 2857 0.161433571655599 4061 8623917 SGTC_3224 9130643 49.47 µM -0.988741493405549 0.15329195453893 no 2858 0.161394817979492 4130 17644395 SGTC_2533 agelasine 13.65 µM -0.990590052683345 0.152833354246685 no 2859 0.160942898446959 4140 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2466 5983409 37.09 µM -0.993848818132377 0.152027120492596 no 2860 0.160148237563505 4102 2879657 SGTC_1065 prochlorperazine maleate 2.48 µM -0.994755728848732 0.15180324993728 no 2861 0.159927541391633 4123 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_435 c-PAF 6.7 µM -0.996406301056406 0.151396369234254 no 2862 0.159526386351459 4080 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1813 st051246 8.6015 µM -0.997639099545866 0.151092947002303 no 2863 0.159227197078612 4001 5291959 SGTC_1349 flufenamic acid 69 µM -0.998443930774765 0.150895076563787 no 2864 0.159032070077251 4006 3371 A non-steroidal anti-inflammatory. SGTC_2629 bisabolol 100 µM -1.00012358670877 0.150482683399834 no 2865 0.158625351413886 4127 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2027 5150920 200 µM -1.00096589571193 0.15027616059315 no 2866 0.158421648320055 4027 786715 SGTC_1834 st055981 52.8 µM -1.00100241033834 0.150267211972952 no 2867 0.1584128215449 4111 471719 YDL150W RPC53 SGTC_2910 7948405 25.97 µM -1.00144547848961 0.150158657793213 no 2868 0.158305743241754 4015 2971328 SGTC_443 clozapine 122 µM -1.00176217536735 0.150081097326779 no 2869 0.158229234772147 4004 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2737 bleomycin 30.5 nM -1.00201140696521 0.150020078188917 no 2870 0.158169041807946 4125 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_766 1391-0721 126 µM -1.00215660796595 0.149984536391073 no 2871 0.158133980636825 4131 1020919 YIL115C NUP159 SGTC_1158 4092-0494 91.8 µM -1.00490318373075 0.149313296678114 no 2872 0.157471735634619 4189 1148199 SGTC_2649 anisomycin 9.56 µM -1.00575907367179 0.149104534989825 no 2873 0.157265739393366 4103 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.00619262399536 0.148998861357241 no 2874 0.157161459805298 4105 688669 SGTC_403 arphamenine a 50 µM -1.0071221374392 0.148772470246904 no 2875 0.156938042086709 4057 5487158 An arginine aminopeptidase inhibitor. SGTC_2506 ethyl hematommate 54.16 µM -1.00750115193112 0.148680223977709 no 2876 0.156847002217501 4176 3940691 An allergen. SGTC_3001 9076041 71.4286 µM -1.00780562364465 0.148606147968508 no 2877 0.156773892815275 4083 16004211 SGTC_3270 9137563 49.47 µM -1.00840263146816 0.14846097143996 no 2878 0.156630605083492 4078 17015724 SGTC_740 k014-0057 261 µM -1.00944245891243 0.148208339410232 no 2879 0.15638124220575 4089 4012779 SGTC_2196 6573537 42.6665 µM -1.01211496272541 0.147560359599188 no 2880 0.155741544492474 4126 2903087 SGTC_1724 st037281 8.293 µM -1.01251285822256 0.147464047740927 no 2881 0.155646450942739 4068 574124 YDL195W SEC31 SGTC_2101 5377231 179.231 µM -1.01288214300819 0.14737469888839 no 2882 0.155558229374036 4147 2844213 SGTC_839 0122-0028 230 µM -1.01511820324185 0.146834456709539 no 2883 0.155024742712212 4090 759448 SGTC_1909 st060837 51.5 µM -1.01592437957069 0.146640007129053 no 2884 0.154832699154412 4095 678937 SGTC_2298 7976326 193.81 µM -1.0163010609984 0.146549210899116 no 2885 0.154743021757878 3983 2235818 SGTC_1402 3909-7673 35.9 µM -1.01665007496144 0.146465117388399 no 2886 0.154659961851841 4111 5328014 SGTC_3338 9144300 39.5675 µM -1.01781171919526 0.146185457251946 no 2887 0.154383720804861 4122 4901274 SGTC_396 dithiazanine 1.25 µM -1.01824845350904 0.146080408440205 no 2888 0.154279949044939 4104 10578 An antihelmenthic. SGTC_502 l-744,832 89.3 µM -1.02137465276032 0.14532993670337 no 2889 0.153538484807719 4127 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2463 5473429 200 µM -1.02158850449817 0.14527869465727 no 2890 0.153487850360474 4090 5399405 SGTC_1361 1608-0041 5.61 µM -1.02476335372246 0.144519383558396 no 2891 0.15273743083509 4090 X1361 SGTC_3263 9137018 49.47 µM -1.02478736694372 0.144513650656729 no 2892 0.15273176426642 4109 43844957 SGTC_1998 st075797 76.8 µM -1.02631464581442 0.144149343812606 no 2893 0.152371647995691 4105 24208315 SGTC_3148 9097893 49.47 µM -1.02804252148175 0.143737935111372 no 2894 0.151964913126023 4114 17174100 SGTC_124 0136-0217 7.121 µM -1.03040209505978 0.143177399467541 no 2895 0.151410645086804 4169 3976905 SGTC_1866 st057638 64 µM -1.03468265811854 0.142164290804681 no 2896 0.150408568739882 4094 688802 SGTC_2124 5246320 200 µM -1.03577464444266 0.141906621889256 no 2897 0.150153644622324 4142 579342 SGTC_348 k064-0012 10.7 µM -1.03864685237171 0.141230396098314 no 2898 0.149484503655423 4037 5066323 SGTC_316 k060-0003 58.6 µM -1.03941763851564 0.141049296458307 no 2899 0.149305272126917 4165 6152314 SGTC_2519 cryptotanshinone 88.04 µM -1.04038066908997 0.140823249531124 no 2900 0.149081539545605 4122 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_414 piperonyl butoxide 100 µM -1.04405962243711 0.139961972625313 no 2901 0.148228902738799 4126 5794 A potent inhibitor of cytochrome P450. SGTC_834 0312-0008 75.7 µM -1.04667771747778 0.13935123699315 no 2902 0.147624122038291 4133 6385573 YIL048W NEO1 SGTC_2600 tangeritin 87.95 µM -1.04697715018442 0.139281502602038 no 2903 0.147555058471685 4076 68077 A bioactive flavone. SGTC_609 0986-0026 86.3 µM -1.04714105626078 0.13924334084303 no 2904 0.147517263024793 4104 2848610 SGTC_3289 9119912 71.43 µM -1.04845401406725 0.138937905602562 no 2905 0.147214739399353 4190 17014829 SGTC_2785 7756463 72.73 µM -1.0492462887553 0.138753818460686 no 2906 0.147032389692547 4100 2201551 SGTC_2358 9037157 4 µM -1.05496650133654 0.137429642064016 no 2907 0.145720322833869 4150 2388925 SGTC_1290 0986-0249 10.2 µM -1.05529395930851 0.1373541005541 no 2908 0.145645451485707 4014 53329 SGTC_9 0092-0002 10.449 µM -1.05549575187442 0.137307563008457 no 2909 0.145599325679324 4125 759368 SGTC_1137 ixabepilone 100 µM -1.05649086642886 0.137078226473197 no 2910 0.145372005751782 4103 154225 A novel microtubule stabilizer. SGTC_2412 st077135 33.4 µM -1.0567631556042 0.137015519672001 no 2911 0.145309846740921 4240 13258915 SGTC_2743 auranofin 4.32 µM -1.05740892506082 0.136866880653214 no 2912 0.145162500001284 4122 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_450 aminopyrene 156 nM -1.05873782186299 0.136561350685203 no 2913 0.144859598931831 4069 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_3255 9139072 49.47 µM -1.06131938554549 0.135969150974339 no 2914 0.144272389374303 4174 17646060 SGTC_889 0919-1524 82.7 µM -1.06156497382879 0.135912905793764 no 2915 0.144216610890205 4184 3905452 SGTC_1708 st033234 31.827 µM -1.06360138120033 0.135447136924638 no 2916 0.143754658226444 4253 674664 SGTC_1338 1486-1223 76 µM -1.06632977990209 0.134824811523392 no 2917 0.143137296064239 4173 3444526 SGTC_2807 7945238 51.95 µM -1.06769653812005 0.134513803797518 no 2918 0.142828710275736 4191 17148797 SGTC_1470 k295-0292 231 µM -1.06893917768335 0.134231467193333 no 2919 0.142548538463706 4245 5045612 SGTC_2094 5332512 191.667 µM -1.07211924102864 0.13351078863446 no 2920 0.141833238825182 4193 755774 SGTC_581 0958-0271 211 µM -1.07512879839913 0.132831205859004 no 2921 0.141158533830454 4163 4591145 SGTC_901 1112-0062 60.1 µM -1.07513640138953 0.132829492063198 no 2922 0.141156832095899 4193 1908457 SGTC_286 k060-0067 22.9 µM -1.07689844522709 0.132432719053777 no 2923 0.140762818890412 4174 5985051 SGTC_1303 1160-0052 261 µM -1.07925481092034 0.131903395546064 no 2924 0.140237075813273 4113 3562476 SGTC_2024 5144227 134 µM -1.07980573126463 0.131779850027492 no 2925 0.140114349240072 4215 3475211 SGTC_2346 9031566 143.75 µM -1.08318485645613 0.131023817963708 no 2926 0.139363190013967 4153 4771086 SGTC_2366 9070441 60.58 µM -1.08572859193139 0.130456673352104 no 2927 0.138799543526257 4166 6837235 SGTC_2252 omeprazole 400 µM -1.08603819194213 0.130387761819516 no 2928 0.138731047805441 4149 4594 A proton pump inhibitor. SGTC_1649 st011737 51.3 µM -1.08617810378673 0.130356628158593 no 2929 0.138700101347275 4174 1761035 SGTC_1816 st051957 91.6 µM -1.08665100416506 0.13025143482019 no 2930 0.138595537493404 4166 674121 SGTC_1579 chlormadinone acetate 49.4 µM -1.08970878031136 0.129572671874915 no 2931 0.13792072357208 4215 45114258 A steroidal progestin. SGTC_294 k038-0071 157 µM -1.08992706708527 0.129524310611712 no 2932 0.137872636200924 4178 24152826 SGTC_728 3030-5151 22.5 µM -1.09164577412856 0.129143969263327 no 2933 0.137494414115536 4250 3125388 SGTC_2262 9014885 67.46 µM -1.09241547322008 0.128973889939832 no 2934 0.137325262460728 4155 6457424 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.09247192956837 0.128961420977664 no 2935 0.137312861020795 4102 5355888 SGTC_1355 1499-0035 1.68 µM -1.09496636861096 0.128411332933 no 2936 0.136765685363488 4183 1548538 SGTC_2861 9024595 19.48 µM -1.09752882685907 0.127847943238182 no 2937 0.136205143205798 4094 16482810 SGTC_801 0866-0028 10.1 µM -1.09826565554805 0.127686260343764 no 2938 0.136044252109312 4213 6849771 SGTC_1086 cerivastatin 2.18 µM -1.1000746677479 0.12728991040571 no 2939 0.135649795082967 4164 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_921 1561-0023 372 µM -1.10337045931886 0.126570012660755 no 2940 0.134933159891848 4162 24050882 SGTC_3261 9137475 49.47 µM -1.10434476719937 0.126357739333331 no 2941 0.134721805139372 4123 17027690 SGTC_3271 9137798 49.47 µM -1.106620203839 0.125862954487204 no 2942 0.134229084186988 4149 6498326 SGTC_1485 3909-9022 254 µM -1.10674969340461 0.125834838177366 no 2943 0.134201081905664 4250 714516 SGTC_522 1273-0010 11.6 µM -1.10977214266074 0.125179812353179 no 2944 0.133548613174742 4289 5705015 SGTC_2504 purpurogallin 52.29 µM -1.11084262267 0.124948389693236 no 2945 0.133318048209046 4097 5281571 An antioxidant. SGTC_1381 2324-0066 62.1 µM -1.11337501931312 0.124402111648219 no 2946 0.132773699561225 4255 10885928 SGTC_3181 9108277 49.47 µM -1.1153283361451 0.123981892784881 no 2947 0.132354873451798 4161 17097298 SGTC_1223 0764-0573 147 µM -1.11535742590863 0.123975642193067 no 2948 0.132348642974522 4208 1609797 SGTC_867 0518-0118 155 µM -1.11626010234701 0.123781791389468 no 2949 0.132155407205067 4184 6848158 SGTC_2148 5546263 113.568 µM -1.11792057583629 0.123425757192332 no 2950 0.131800458190716 4195 792097 SGTC_2594 a-mangostin 100 µM -1.11798446969132 0.123412071593989 no 2951 0.131786813155478 4243 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_250 brefeldin a 552.239 µM -1.1195385288531 0.123079530769372 no 2952 0.131455231716743 4082 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_105 0111-0055 734.78 µM -1.12210973099989 0.122530719784573 no 2953 0.130907893456925 4222 5179370 SGTC_2931 9014674 55.67 µM -1.12269182841962 0.12240671256286 no 2954 0.130784199857306 4185 2996810 SGTC_60 0986-0278 202 µM -1.12682089284444 0.1215296047056 no 2955 0.129909107573082 4174 3110598 SGTC_2524 avocatin b 10.57 µM -1.12827421435889 0.121221939597558 no 2956 0.129602064923013 4194 6710748 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.1302897355682 0.120796165264005 no 2957 0.12917707913453 4238 7104 SGTC_449 xestospongin c 11.1929 µM -1.13041694012401 0.120769328942779 no 2958 0.129150289672584 4234 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1557 sumaresinolic acid 42.3 µM -1.13188567462904 0.12045977423282 no 2959 0.128841251044242 4197 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1752 st044819 83.042 µM -1.13349946578337 0.120120291752344 no 2960 0.128502282703685 4198 441209 YML126C ERG13 SGTC_1016 4226-1401 38 µM -1.13379076343506 0.12005908531183 no 2961 0.128441163174158 4189 2901613 SGTC_1790 st045711 43.5 µM -1.1343672061785 0.119938029977123 no 2962 0.128320274519064 4225 585119 SGTC_2156 5649887 115 µM -1.13645326906581 0.119500667432062 no 2963 0.127883456315756 4263 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3122 9126309 49.47 µM -1.13668279121984 0.119452614768621 no 2964 0.127835457920391 4276 17591206 SGTC_2380 9035439 200 µM -1.13718321277576 0.119347893986671 no 2965 0.127730851597365 4331 6462575 SGTC_1732 st034308 51.822 µM -1.13788991278641 0.119200116689435 no 2966 0.127583226930211 4098 830119 SGTC_1017 4239-0030 168 µM -1.13797874835194 0.119181549519904 no 2967 0.127564678201028 4253 1149593 SGTC_1260 0700-1617 7.75 µM -1.13839528424644 0.119094518230889 no 2968 0.127477731155082 4210 2853078 SGTC_1545 lovastatin 49.4 µM -1.14052693094968 0.118649832901627 no 2969 0.127033419707273 4271 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_14 0354-0009 295 µM -1.14610832880794 0.117491052126196 no 2970 0.125875165912782 4323 1713507 SGTC_956 1185-0240 191 µM -1.14715627081105 0.117274380370689 no 2971 0.125658520453647 4218 1416193 SGTC_148 3253-0744 288.01 µM -1.14892957076667 0.116908379067268 no 2972 0.125292511533187 4115 6893655 SGTC_2161 5662504 8.5105 µM -1.15007181314525 0.11667305438482 no 2973 0.125057147316642 4204 2859334 SGTC_2556 citropten 84.59 µM -1.15023421371222 0.116639623923653 no 2974 0.125023709034722 4274 2775 A potential DNA crosslinker. SGTC_2738 aclarubicin 5.55 µM -1.15248302536605 0.116177399948811 no 2975 0.124561320555514 4214 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_56 0957-0365 83.25 µM -1.15432027264976 0.115800735520816 no 2976 0.124184444065814 4215 6752360 SGTC_593 1203-0218 61.7 µM -1.15569033124877 0.115520417139762 no 2977 0.123903922204167 4270 3666956 SGTC_955 1216-0110 33 µM -1.15611336815824 0.115433959930415 no 2978 0.12381739435153 4225 3619719 SGTC_3140 9094243 49.47 µM -1.15641604121023 0.115372130036777 no 2979 0.123755511653794 4224 19291112 SGTC_1820 st053765 18.6 µM -1.15664611183794 0.115325147076659 no 2980 0.123708487294944 4287 3690829 SGTC_2746 daunorubicin 9.88 µM -1.15696545900895 0.115259955402205 no 2981 0.123643236353326 4204 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_679 0422-0091 41.4 µM -1.15705523186904 0.115241633848386 no 2982 0.123624897761165 4260 627384 YHR062C RPP1 SGTC_232 clozapine 119 µM -1.15828288321737 0.114991292790162 no 2983 0.123374307090227 4216 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1669 st015249 58.4 µM -1.15896347802362 0.114852673544487 no 2984 0.123235536135405 4334 722793 SGTC_2004 4023728 41.89 µM -1.15969718794942 0.114703369340459 no 2985 0.12308605774777 4222 360084 YDR527W RBA50 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.1605498096888 0.114530041072207 no 2986 0.122912513219635 4233 689007 SGTC_2525 harmine 47.85 µM -1.16893374042941 0.112835607457389 no 2987 0.121215164127194 4242 5280953 A monoamine oxidase inhibitor SGTC_1194 1488-0194 225 µM -1.17080137168885 0.112460599977719 no 2988 0.120839313170993 4213 1391452 SGTC_2874 9043904 71.43 µM -1.17350672450563 0.111918964107836 no 2989 0.120296330916606 4198 4463428 SGTC_2138 5575593 77.673 µM -1.18041238397112 0.110544853868243 no 2990 0.11891811944448 4273 762213 SGTC_2238 6671620 73.2395 µM -1.18581406329591 0.10947847121865 no 2991 0.117847868237146 4195 729941 SGTC_442 cape 100 µM -1.19561777911582 0.107561963589099 no 2992 0.115922875073152 4286 5281787 SGTC_2026 5148700 152 µM -1.19616131011503 0.107456421687912 no 2993 0.115816807930818 4251 79838 SGTC_2089 5281248 129.67 µM -1.19773190983748 0.107151864882543 no 2994 0.115510701231448 4270 2737878 SGTC_2915 7971052 15.16 µM -1.19876557589889 0.10695176544216 no 2995 0.11530955573559 4191 5741558 SGTC_3281 9140613 49.47 µM -1.20470016993887 0.105808148470593 no 2996 0.114159535205611 4292 16013766 SGTC_2439 5492030 7.2 µM -1.2048606666166 0.105777343435236 no 2997 0.114128547616224 4289 5722370 SGTC_2610 ononetin 44.17 µM -1.20788543342995 0.105197994827267 no 2998 0.11354566667184 4265 259632 SGTC_2212 7123476 200 µM -1.21057315408137 0.104685131958597 no 2999 0.113029519141872 4288 1085715 SGTC_2921 7974240 10.71 µM -1.21454773073141 0.103930037846916 no 3000 0.112269317374527 4392 2979074 YDR527W RBA50 SGTC_1721 st082152 9.2685 µM -1.21550069433121 0.103749581373599 no 3001 0.112087592062237 4228 5296051 SGTC_1964 st076914 61 µM -1.22170686671267 0.102579917555615 no 3002 0.110909249314302 4357 24208661 SGTC_1340 1486-1359 257 µM -1.22718068844735 0.101556259815724 no 3003 0.10987734303105 4234 4309068 SGTC_2902 5787006 60.46 µM -1.23137882482152 0.10077622308922 no 3004 0.10909060645956 4259 591003 SGTC_2199 6590217 200 µM -1.23231803414239 0.100602312513786 no 3005 0.108915152866224 4210 703109 SGTC_1475 4092-1048 11.7 µM -1.23943621765037 0.0992913726454402 no 3006 0.107591997897448 4306 2881759 SGTC_2249 haloperidol 116.36 µM -1.24015741114528 0.0991592521325599 no 3007 0.107458588726425 4282 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_537 1334-0398 209 µM -1.24049081654696 0.0990982167253951 no 3008 0.107396954416945 4343 5846986 SGTC_2543 pimpinellin 60.67 µM -1.24607659215923 0.0980797308433382 no 3009 0.106368138764566 4161 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1839 st053978 48 µM -1.2473928518859 0.0978408503232271 no 3010 0.106126743129593 4341 3788398 SGTC_1529 apigenin 74 µM -1.24784786002737 0.0977583727451101 no 3011 0.106043388970472 4338 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_17 0960-0276 49.807 µM -1.24873151887503 0.0975983409356657 no 3012 0.105881644300629 4297 6821114 SGTC_1509 1326-1131 80 µM -1.2499932680645 0.0973701695647544 no 3013 0.10565100325389 4295 768313 SGTC_202 3594-0513 34.79 µM -1.25177491759928 0.0970486475606145 no 3014 0.105325946123165 4392 708429 SGTC_309 k408-0051 1.48 µM -1.25193843666525 0.0970191774919944 no 3015 0.105296148802099 4234 3640463 SGTC_547 1120-0019 610 nM -1.25241311475138 0.0969336662969478 no 3016 0.105209684966032 4279 3676939 SGTC_2246 7293507 91.5585 µM -1.25721163538692 0.0960723388029118 no 3017 0.104338505572668 4393 887656 SGTC_391 gliotoxin 8.33 µM -1.25832290352203 0.0958736727444087 no 3018 0.10413750065959 4412 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1737 st035557 69.7 µM -1.26119846833402 0.0953609988477129 no 3019 0.103618675178636 4184 5716916 SGTC_2402 5553605 200 µM -1.26249243127994 0.0951309624803114 no 3020 0.103385824035703 4417 6758546 SGTC_559 1550-0661 158 µM -1.26420787222145 0.0948266275525963 no 3021 0.103077713015811 4394 5830875 SGTC_2119 5528445 120.635 µM -1.26959129585415 0.0938762178875256 no 3022 0.102115125744923 4367 791935 SGTC_1970 st070122 35.8 µM -1.26998616203094 0.0938067844965799 no 3023 0.10204477969189 4354 102928 SGTC_3152 9099253 49.47 µM -1.27476355576387 0.0929697279489776 no 3024 0.101196471844716 4225 25236131 SGTC_575 k072-0246 11.9 µM -1.27621509259579 0.0927164982900428 no 3025 0.100939747435462 4422 6796779 SGTC_2151 5563267 85.4165 µM -1.28101008429608 0.0918836080455443 no 3026 0.100095062030918 4409 5310824 SGTC_1236 0330-0013 258 µM -1.28144314230126 0.0918086595713408 no 3027 0.10001902942035 4367 4617066 SGTC_244 nsc-207895 1.295 µM -1.28183302377561 0.0917412223181061 no 3028 0.0999506134580788 4123 42640 SGTC_2886 9058944 51.95 µM -1.28337882368576 0.0914742086346317 no 3029 0.0996796946025979 4258 4949929 SGTC_1079 idarubicin 2.36 µM -1.28376824737897 0.0914070324706551 no 3030 0.099611528398779 4368 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1734 st037168 69.4 µM -1.28493731563971 0.0912055861403124 no 3031 0.0994070948817992 4362 708907 SGTC_2331 7980721 200 µM -1.28916926168618 0.090479116977167 no 3032 0.0986696243745234 4312 2981221 SGTC_321 4534-3890 65.3 µM -1.29287535594451 0.0898464534236188 no 3033 0.0980270860989067 4343 699746 SGTC_2843 9000894 45.46 µM -1.29608757310079 0.0893007642146383 no 3034 0.097472657901955 4322 2242070 SGTC_2312 7706453 155.7 µM -1.29739076412188 0.0890800835070036 no 3035 0.0972483843666363 4352 976098 SGTC_1375 2910-0797 186 µM -1.29949640336483 0.0887243753495782 no 3036 0.0968868134839203 4356 742508 SGTC_1418 3966-3099 2.4 µM -1.30230308148637 0.0882518859704791 no 3037 0.096406399343724 4364 740335 SGTC_2518 prenyletin 46.28 µM -1.30462133035715 0.0878630373784016 no 3038 0.0960109106716462 4375 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1441 4106-0040 13 µM -1.30926703151855 0.0870876450996746 no 3039 0.0952219565694009 4387 2904180 SGTC_2311 7694451 200 µM -1.31078774190674 0.0868349439067007 no 3040 0.0949647425434434 4370 2163142 SGTC_1092 toremifene 6.32 µM -1.31204858020299 0.0866258422317296 no 3041 0.0947518718706952 4366 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2749 bexarotene 57.39 µM -1.3136674587948 0.0863579140787151 no 3042 0.0944790681902141 4389 82146 An retinoic acid receptor inhibitor. SGTC_968 1309-0633 340 µM -1.31372093417793 0.0863490743638217 no 3043 0.0944700667313027 4409 3761976 SGTC_2278 7948257 134.34 µM -1.31444751738179 0.086229034027313 no 3044 0.0943478243494834 4380 1247028 SGTC_340 k038-0059 454 µM -1.31703776117623 0.0858021099799327 no 3045 0.0939129837159864 4337 23733424 SGTC_2489 cantharidin 73.42 µM -1.31926077856535 0.0854369754615054 no 3046 0.093540972648133 4333 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2595 hexamethylquercetagetin 100 µM -1.32440090313465 0.0845971593953532 no 3047 0.0926849674087306 4382 386331 SGTC_2341 7987486 176.74 µM -1.32531342466389 0.0844487170516524 no 3048 0.0925336091018054 4409 1258686 SGTC_2255 7941087 197.44 µM -1.32580312315632 0.0843691370936914 no 3049 0.0924524591268164 4478 935561 SGTC_526 4469-0568 170 µM -1.33155076433552 0.0834393012044239 no 3050 0.0915039265543455 4340 2901964 SGTC_490 phenamil 164 µM -1.33191895142619 0.0833800005628486 no 3051 0.091443411400355 4394 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2960 9079389 5.97 µM -1.33266331240015 0.0832602096891441 no 3052 0.0913211590013621 4372 16457355 SGTC_2445 5742597 35.57 µM -1.33508198657554 0.0828718629008471 no 3053 0.0909247572019566 4399 1774255 SGTC_3291 9121177 71.43 µM -1.3359714854065 0.0827293865818435 no 3054 0.0907792968063824 4376 17015612 SGTC_994 3910-0338 138 µM -1.33893058293624 0.0822567368380229 no 3055 0.09029663619805 4464 3479481 SGTC_1024 4507-0395 26 µM -1.33957602668294 0.0821539123222778 no 3056 0.0901916110493421 4451 4201836 SGTC_439 amiodarone 34.4 µM -1.34107999130549 0.0819146940344792 no 3057 0.0899472414237576 4273 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1873 rapamycin 2 nM -1.34279750282667 0.0816421517443902 no 3058 0.0896687761122264 4346 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_619 1652-1634 108 µM -1.34438317888423 0.0813911371638634 no 3059 0.0894122552028691 4381 5400454 SGTC_246 cycloheximide 667 µM -1.34458681264438 0.0813589438987664 no 3060 0.0893793521777237 4312 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_398 bronopol 33.3 µM -1.34708362144974 0.0809649940840833 no 3061 0.0889766512468594 4326 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3307 9126885 69.2785 µM -1.34793820082566 0.0808304886874621 no 3062 0.0888391300514457 4367 24824909 SGTC_1169 aniline yellow 25.8 µM -1.35093215671657 0.0803605896724665 no 3063 0.0883585830915505 4332 6051 A DNA damaging agent. SGTC_1097 itavastatin 7.23 µM -1.35222660643163 0.0801580671263897 no 3064 0.0881514173688875 4416 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_3232 9132874 49.47 µM -1.35410146089407 0.0798654219982273 no 3065 0.0878520050989577 4372 3784940 SGTC_605 1315-0399 119 µM -1.35465191187045 0.0797796559951999 no 3066 0.0877642428648805 4472 24020461 SGTC_2994 9053520 71.4286 µM -1.35627239118028 0.0795275728416568 no 3067 0.0875062582396468 4437 4647384 SGTC_3213 9129884 49.47 µM -1.35737218914803 0.0793568309832415 no 3068 0.0873314901449631 4386 17190742 SGTC_3247 9135149 49.47 µM -1.35785784524004 0.0792815220369704 no 3069 0.0872543978799512 4453 8934436 YOR116C RPO31 SGTC_2555 cholic acid 100 µM -1.35895844539473 0.0791110561752954 no 3070 0.0870798784520712 4357 6708657 Influences liver metabolism. SGTC_3183 9108214 49.47 µM -1.35961411922017 0.0790096345009218 no 3071 0.0869760338748729 4392 4974831 SGTC_2248 tofa 1.1 µM -1.35985463298812 0.0789724557783538 no 3072 0.0869379648857409 4422 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2630 antimycin a 100 µM -1.36139581835614 0.0787345331250294 no 3073 0.086694318443442 4343 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_141 0443-0274 32.331 µM -1.36529562173564 0.0781349219614336 no 3074 0.0860800772648079 4358 1627241 SGTC_473 2-arachidonoylglycerol 10 µM -1.36768056980567 0.0777699368728211 no 3075 0.0857060422393783 4240 5282280 An endocannabinoid. SGTC_2220 6782180 200 µM -1.37084291054271 0.0772879794424293 no 3076 0.0852119655500326 4357 833803 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.37560579694048 0.0765663772387383 no 3077 0.0844718555005266 4318 4330530 SGTC_552 k242-0005 476 µM -1.38041807249056 0.0758425084407782 no 3078 0.0837289794360292 4465 4088318 SGTC_22 0964-0034 14.468 µM -1.38065757549917 0.0758066187048341 no 3079 0.083692135718884 4422 138402 SGTC_262 fenpropimorph 62.5 µM -1.38071200112997 0.0757984647803117 no 3080 0.0836837649024551 4447 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2348 9022543 33.42 µM -1.39074431553242 0.0743068272367457 no 3081 0.0821514871048831 4433 3162678 YDL140C RPO21 SGTC_1947 st076332 61.6 µM -1.39166561519332 0.0741709770983726 no 3082 0.0820118396286556 4304 24208416 SGTC_2700 st077718 96.8 µM -1.39484484482698 0.0737036407273799 no 3083 0.0815313161990809 4406 904970 SGTC_24 0417-1663 219 µM -1.39505630215432 0.0736726372089283 no 3084 0.0814994310251891 4460 4329390 SGTC_2808 7946468 45.46 µM -1.39557003424451 0.0735973562071588 no 3085 0.0814220056971434 4413 2970879 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.3971137641467 0.0733714958199794 no 3086 0.081189681686984 4413 6312947 SGTC_2825 7998094 58.44 µM -1.39751882548282 0.0733123199089876 no 3087 0.0811288048009944 4397 2987815 SGTC_1300 1094-0077 113 µM -1.39833837131196 0.0731927031146884 no 3088 0.0810057401752068 4404 5532636 SGTC_3011 9081274 71.4286 µM -1.39919459391019 0.0730678927215491 no 3089 0.0808773186464586 4431 6625322 SGTC_3287 9117173 37.0625 µM -1.40516632356394 0.0722019268840926 no 3090 0.0799859128424828 4445 2789709 SGTC_3009 9080819 71.4286 µM -1.41395764024042 0.0709414326947223 no 3091 0.0786871701362937 4451 17027216 SGTC_2670 beta-carotene 100 µM -1.41649313383878 0.0705810537429586 no 3092 0.0783155865268913 4409 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_836 0330-0104 1.35 µM -1.41721915405199 0.0704781214211382 no 3093 0.0782094316979355 4468 46494820 SGTC_2973 9094665 17.96 µM -1.42227279882817 0.0697648298461744 no 3094 0.0774735361216572 4441 25237061 YIL048W NEO1 SGTC_1406 3909-7906 11.9 µM -1.42331080638743 0.0696190115738052 no 3095 0.0773230378496829 4478 X1406 SGTC_519 k048-0011 62.8 µM -1.42347475418763 0.0695960018231243 no 3096 0.0772992877660897 4471 6836379 SGTC_2192 5915882 198.485 µM -1.42544254549987 0.0693202828985137 no 3097 0.0770146585202077 4417 2876149 SGTC_687 k029-0044 34.9 µM -1.42737933859192 0.0690497297246702 no 3098 0.0767352915062285 4514 5829338 SGTC_608 k048-0125 159 µM -1.42743249986781 0.0690423150477682 no 3099 0.0767276342948148 4498 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1273 0849-0096 14.1 µM -1.42919803991064 0.0687964145204822 no 3100 0.0764736604616635 4469 5286025 SGTC_2241 6772625 37.8075 µM -1.43257699676979 0.06832768435803 no 3101 0.0759893797413125 4254 2285411 SGTC_2820 7989630 71.43 µM -1.43331090682898 0.068226202593376 no 3102 0.0758845032072852 4484 2984098 SGTC_2753 fluvastatin 17.09 µM -1.43331917856864 0.0682250594779162 no 3103 0.0758833217953173 4445 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_55 0767-0285 6.563 µM -1.43723648029123 0.0676853660879579 no 3104 0.0753254053115959 4372 3116166 SGTC_2268 7933382 153.85 µM -1.43883391770216 0.067466233427658 no 3105 0.075098792027672 4503 935025 YOR257W CDC31 SGTC_1042 0350-0096 82 µM -1.43966850459867 0.0673519650468153 no 3106 0.0749806040555373 4449 3122515 SGTC_914 3820-6779 408 µM -1.44797553550031 0.0662227393791844 no 3107 0.0738119463553701 4398 2893481 SGTC_2384 9036245 200 µM -1.44937216651757 0.0660343350918443 no 3108 0.0736168386400957 4405 6462766 SGTC_1403 3909-7815 62.9 µM -1.45700127377405 0.0650124966656096 no 3109 0.0725580143045525 4458 6615483 SGTC_902 1120-0002 2.07 µM -1.45951237119912 0.0646788597719659 no 3110 0.0722120690840358 4460 3280475 SGTC_2108 5365811 200 µM -1.4627550969427 0.06424998425469 no 3111 0.0717672019761442 4468 780283 SGTC_3095 9117207 49.47 µM -1.46346244250443 0.0641567266531429 no 3112 0.0716704416387224 4467 17015229 SGTC_2237 6667747 47.222 µM -1.46363236398938 0.0641343396075622 no 3113 0.071647212384446 4469 729940 YDL015C TSC13 SGTC_561 1550-0330 72.9 µM -1.4679923361229 0.0635619906023695 no 3114 0.0710531523402892 4431 6812934 SGTC_166 k072-0058 166.424 µM -1.46895709942873 0.063435881388429 no 3115 0.0709222128506164 4359 5846229 SGTC_1897 st060201 15 µM -1.47203362813346 0.0630350328014333 no 3116 0.0705058984214062 4484 611878 SGTC_1063 disulfiram 1.84 µM -1.47445175166434 0.0627213564333792 no 3117 0.0701799996362433 4499 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2235 salicylic acid 500 µM -1.47597430439073 0.0625244775057375 no 3118 0.0699753952130905 4536 338 A COX inhibitor and kinase inhibitor. SGTC_2324 6149169 200 µM -1.47600619290175 0.0625203592088293 no 3119 0.0699711148679422 4419 2888231 SGTC_2054 5233173 129 µM -1.48378952454426 0.0615214774398716 no 3120 0.06893238351781 4486 6889 SGTC_3240 9133527 49.47 µM -1.48438643885437 0.0614453893950261 no 3121 0.0688532151767444 4460 17617455 SGTC_1683 st010134 710 nM -1.48943573911273 0.0608046977115493 no 3122 0.0681863316488331 4454 3818134 SGTC_818 4072-2707 53.5 µM -1.49562225873056 0.0600268425348031 no 3123 0.0673760596705767 4417 882871 SGTC_682 0kpi-0099 17 µM -1.49912996163316 0.0595892796048697 no 3124 0.0669199600944218 4498 1714895 YML126C ERG13 SGTC_1681 tripelennamine 100 µM -1.50247496703409 0.0591743443377879 no 3125 0.0664872440962702 4398 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3282 9108498 15.4605 µM -1.50981589341081 0.0582716750876707 no 3126 0.0655452042159182 4477 16459645 SGTC_2263 7948595 193.29 µM -1.51115324860125 0.0581083995026096 no 3127 0.0653747052985841 4519 2971371 SGTC_2038 4100038 30.985 µM -1.51886859714917 0.0571734535290248 no 3128 0.0643977874404616 4467 3596803 SGTC_1142 3253-1408 9.78 µM -1.52006439971218 0.0570296118725718 no 3129 0.0642473954485783 4515 256655 SGTC_1671 st016596 74.5 µM -1.52084199554595 0.056936228777381 no 3130 0.0641497464470689 4560 2829167 SGTC_1615 st002656 86.5 µM -1.52290470692882 0.0566890967693338 no 3131 0.0638912740122486 4514 1584458 SGTC_2400 5203494 178.7 µM -1.52442101501316 0.0565079684605226 no 3132 0.0637017868827771 4405 6777674 SGTC_2748 diazoxide 86.69 µM -1.53112418639431 0.0557127097018855 no 3133 0.0628693516348351 4588 3019 A potassium channel activatior. SGTC_269 exalamide 29 µM -1.53131987530278 0.0556896267034804 no 3134 0.0628451778877845 4476 3316 A derivative of salicylamide. SGTC_2626 ethyl orsellinate 100 µM -1.53223494423598 0.0555817874988117 no 3135 0.0627322341389886 4450 75653 A natural product. SGTC_694 1315-0438 43.2 µM -1.53807872383764 0.0548969913816748 no 3136 0.0620146837288065 4542 6793154 SGTC_973 1325-0077 65.9 µM -1.54058831142178 0.0546049627292641 no 3137 0.0617085072400105 4524 2835149 SGTC_2853 9015042 58.44 µM -1.54214066664137 0.0544249384285551 no 3138 0.061519707304135 4449 6457456 SGTC_2948 9070189 9.45 µM -1.54441065818101 0.0541625364765897 no 3139 0.061244439829007 4461 6473636 YDL196W YDL196W SGTC_1067 clotrimazole 1.36 µM -1.54514657920629 0.0540776821824586 no 3140 0.061155406229766 4546 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_205 1486-1330 71.903 µM -1.54556464421998 0.0540295246950721 no 3141 0.0611048727314603 4594 4118834 SGTC_3218 9131285 49.47 µM -1.5600618075076 0.0523804769637238 no 3142 0.0593726379389506 4509 17156417 SGTC_58 0957-0393 9 µM -1.57008005955511 0.0512644379355726 no 3143 0.0581982434939803 4107 6997992 SGTC_613 3914-0030 117 µM -1.5726539970848 0.0509807759585093 no 3144 0.0578994786402409 4259 1145395 SGTC_2476 5806916 10.51 µM -1.57336218237253 0.0509029496282851 no 3145 0.05781748923474 4454 2870194 SGTC_1827 berberine 7.24 µM -1.57508220109092 0.050714321232237 no 3146 0.057618735936747 4443 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2474 5321570 43.32 µM -1.58102830267702 0.05006651837476 no 3147 0.0569357832657655 4538 2841384 SGTC_1860 st056228 74.6 µM -1.58183654910403 0.0499789749453637 no 3148 0.0568434444820892 4522 688679 SGTC_3305 9127027 53.8275 µM -1.58209750736688 0.049950735909705 no 3149 0.0568136562888808 4482 41905295 SGTC_981 1488-1094 54.9 µM -1.58354758538016 0.0497940505738753 no 3150 0.0566483548634217 4506 3449522 SGTC_2968 9090663 33.37 µM -1.58739128859768 0.0493806233298097 no 3151 0.0562120255382329 4475 25236811 SGTC_1173 0443-0020 122 µM -1.5876031976806 0.0493579104142925 no 3152 0.0561880473390608 4533 5331295 SGTC_1962 st076595 64.5 µM -1.587860503308 0.0493303430029035 no 3153 0.0561589432161048 4508 279619 SGTC_851 0394-0702 453 µM -1.58851961586434 0.049259782561882 no 3154 0.0560844444934052 4545 762646 SGTC_2201 6605497 169.863 µM -1.59301327747076 0.0487808647844505 no 3155 0.0555786062396545 4507 670741 SGTC_2836 9010338 19.48 µM -1.59645227146258 0.0484168691802788 no 3156 0.0551939268706174 4499 2994051 SGTC_2805 7950783 58.44 µM -1.5975538478528 0.0483007347643565 no 3157 0.0550711523295611 4546 1178958 YDL195W SEC31 SGTC_3119 9125183 49.47 µM -1.59884306599881 0.0481651012102305 no 3158 0.0549277386029924 4428 22695334 SGTC_2884 9058502 51.95 µM -1.60239575370332 0.0477929135228803 no 3159 0.0545340616185848 4521 6471554 SGTC_2581 avocatin a 64 µM -1.60630099566004 0.0473864521100154 no 3160 0.0541038958535899 4478 6710728 A skin care supplement. SGTC_1971 st069429 63.5 µM -1.60637650116694 0.0473786208034543 no 3161 0.0540956053976 4542 1246522 YGL099W LSG1 SGTC_2638 epoxomicin 18 µM -1.60667750036716 0.0473474119703373 no 3162 0.0540625658723921 4507 9915668 A protesome inhibitor. SGTC_256 clotrimazole 625 nM -1.60675306420386 0.0473395797889543 no 3163 0.0540542740291781 4495 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2803 7707263 71.43 µM -1.6129720767218 0.0466985309070491 no 3164 0.0533752872218439 4512 2199229 SGTC_2000 st075254 36.4 µM -1.61453540196964 0.04653848541796 no 3165 0.0532056721705373 4433 17234175 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.62490939692842 0.0454875703951222 no 3166 0.052090932820158 4558 688662 SGTC_3272 9137413 49.47 µM -1.62638873924096 0.0453392758009024 no 3167 0.0519334924074169 4495 17614870 SGTC_1668 st014914 51.6 µM -1.63051465355838 0.0449277333025271 no 3168 0.0514963853701613 4583 2839556 SGTC_485 niflumic acid 177 µM -1.63281541068406 0.0446995517359217 no 3169 0.0512539124638117 4601 4488 A COX2 inhibitor. SGTC_211 3455-0679 143.504 µM -1.63790055230279 0.0441985347538456 no 3170 0.0507212203735458 4538 748649 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.64236708856304 0.0437622096382728 no 3171 0.0502569756203222 4614 165521 SGTC_1440 4100-1550 40 µM -1.64978292679379 0.0430454547635919 no 3172 0.0494936709845183 4601 742806 SGTC_1397 3532-0190 20.1 µM -1.65545559475674 0.042503607293347 no 3173 0.0489160583834323 4568 5322280 SGTC_2784 7567673 72.73 µM -1.66057039247512 0.0420197884712169 no 3174 0.0483998797158006 4499 3471247 SGTC_107 0358-0022 2.6945 µM -1.66646277833708 0.0414679524473465 no 3175 0.0478106379468163 4590 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2654 protoveratrine a 100 µM -1.6672825149337 0.041391649592497 no 3176 0.047729120882898 4579 5702278 A heart drug and vasodilator. SGTC_2443 5493264 126.67 µM -1.66981757734814 0.0411564003125189 no 3177 0.0474777307986914 4595 5340055 SGTC_2505 galangin 7.89 µM -1.66999591747431 0.0411398915643871 no 3178 0.0474600856701002 4512 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3303 9125618 40.5795 µM -1.6723841916575 0.0409193286586355 no 3179 0.0472242936658121 4561 22695467 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.67353486789778 0.0408134038538621 no 3180 0.0471110241748192 4527 2724 A muscle relaxant with antifungal properties. SGTC_2841 9004761 38.96 µM -1.67620513176271 0.0405684513793019 no 3181 0.046849009682278 4524 2991039 SGTC_138 0850-0259 40.9225 µM -1.68073040411436 0.0401560584783884 no 3182 0.0464076460777044 4521 6813004 SGTC_952 1185-0122 232 µM -1.68075181066266 0.0401541158004459 no 3183 0.0464055661918755 4537 678600 SGTC_353 1988-1175 58.3 µM -1.68279828628188 0.0399687471784901 no 3184 0.0462070734545898 4408 2788357 SGTC_730 1436-0052 41.2 µM -1.69127804512691 0.0392080530351368 no 3185 0.0453918555852379 4611 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3202 9113761 49.47 µM -1.69768117655761 0.0386414897124381 no 3186 0.044783976175235 4518 4798415 SGTC_1802 st050112 57.9 µM -1.70339003508314 0.0381419988939987 no 3187 0.0442475506496197 4603 4662563 SGTC_2362 9071156 126 µM -1.7055076447817 0.0379580649368426 no 3188 0.0440498938622175 4591 653133 SGTC_2176 5809774 33.9695 µM -1.70850122823317 0.0376992798534118 no 3189 0.0437716893396655 4526 2870539 SGTC_2859 9028643 45.46 µM -1.72150021716749 0.0365922161805299 no 3190 0.0425800464021729 4445 17151580 SGTC_1662 st014054 52 µM -1.72509664958877 0.0362906662435345 no 3191 0.0422550281237303 4672 2838777 SGTC_2814 7977482 42.97 µM -1.72788285115326 0.0360584527046038 no 3192 0.0420046147169613 4584 6456762 SGTC_2862 9027634 71.43 µM -1.73091117973205 0.0358074408608593 no 3193 0.0417338036707749 4560 5012562 SGTC_1471 k673-0312 37 µM -1.74239922019664 0.0348682072427806 no 3194 0.0407193061410817 4603 24099884 SGTC_1844 rapamycin 4 nM -1.74343371274242 0.0347846316206579 no 3195 0.0406289418711956 4450 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2032 5185112 25.99 µM -1.74601325279365 0.034576949378189 no 3196 0.0404043244948268 4487 5718189 SGTC_1161 k007-0610 110 µM -1.74736056498621 0.0344688810389039 no 3197 0.0402874067138098 4548 5843850 SGTC_908 3448-7491 47.7 µM -1.759847240976 0.0334804666491607 no 3198 0.0392168553826895 4604 1203031 SGTC_1154 4088-0362 150 µM -1.76002155874521 0.0334668349966639 no 3199 0.039202075650183 4629 6618304 SGTC_2269 7935389 174.42 µM -1.76010187205895 0.033460556031933 no 3200 0.0391952677192 4626 97605 SGTC_2586 curcumin 80 µM -1.77419429162498 0.0323737201076024 no 3201 0.0380155090566855 4508 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_767 0929-0023 86 µM -1.7805499306465 0.0318931796571553 no 3202 0.0374930027663727 4649 1204563 SGTC_1874 staurosporine 7.6 µM -1.78254830208651 0.0317433087988888 no 3203 0.0373299308922182 4608 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2958 9077254 16.72 µM -1.78677811558471 0.0314280064435081 no 3204 0.036986678885113 4622 16457351 SGTC_2473 5854593 8.94 µM -1.79096061683429 0.0311187813416773 no 3205 0.0366498075719651 4606 2872951 SGTC_1020 4335-0961 93.3 µM -1.79433170223511 0.0308713824591276 no 3206 0.0363801204614196 4597 669075 SGTC_784 4579-0127 173 µM -1.8007043274663 0.0304081526288501 no 3207 0.0358747475865026 4629 1948547 SGTC_623 k072-0108 16.9 µM -1.80860988823754 0.0298415113438717 no 3208 0.0352558155994737 4606 5382803 SGTC_3327 9140648 26.9345 µM -1.80960325430315 0.0297709340122018 no 3209 0.0351786674564075 4641 8029710 SGTC_1196 1588-0294 184 µM -1.81392910346204 0.0294652009569582 no 3210 0.0348443207022911 4669 6144269 SGTC_2582 agaric acid 100 µM -1.81639433902279 0.0292921374133755 no 3211 0.0346549514821969 4273 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1398 3558-0053 112 µM -1.82089107902379 0.028978633349309 no 3212 0.0343117077692079 4636 4532369 SGTC_1825 st052143 62.6 µM -1.82213339947959 0.0288925144210511 no 3213 0.0342173735082751 4669 674173 SGTC_1505 k297-0037 20.6 µM -1.82930509226736 0.0283995143110289 no 3214 0.0336769581188451 4624 4089396 SGTC_179 1273-0063 6.77 µM -1.82983386674327 0.0283634437940711 no 3215 0.0336373924705934 4601 3108139 SGTC_729 4092-0585 94.1 µM -1.83365209842093 0.0281041119410227 no 3216 0.0333528267009167 4652 2169061 SGTC_2847 9005661 71.43 µM -1.83397944720211 0.0280819708034298 no 3217 0.0333285225405397 4673 2991449 SGTC_3085 9117376 49.47 µM -1.83941743738487 0.0277162771428435 no 3218 0.032926905649366 4674 16480349 SGTC_803 4488-1585 147 µM -1.84624951242058 0.0272624675196019 no 3219 0.0324279923973086 4647 747204 SGTC_2650 prasterone 100 µM -1.85277425841097 0.0268348746008436 no 3220 0.0319573606401316 4675 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_74 000s-0487 160.283 µM -1.85437569031032 0.0267307864601529 no 3221 0.0318427151033596 4533 677548 SGTC_1062 mesoridazine 14.2 µM -1.85756198495425 0.026524689814964 no 3222 0.0316156205864638 4700 4078 A neuroleptic. SGTC_1705 st027868 56.3335 µM -1.85773544564627 0.0265135082019609 no 3223 0.0316032961609192 4584 292948 SGTC_2648 atorvastatin 78.68 µM -1.86686222809865 0.0259307091038891 no 3224 0.0309604148949608 4662 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2972 9093619 59.92 µM -1.87291160886382 0.0255503569873405 no 3225 0.0305402959294603 4612 25236256 SGTC_1052 3253-3998 198 µM -1.87320035867264 0.0255323194036303 no 3226 0.0305203614131719 4616 5450317 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.87594929351743 0.0253611326808255 no 3227 0.0303311214879693 4653 2333 A French combination drug. SGTC_1987 st072290 61.9 µM -1.87918083772496 0.0251611225458363 no 3228 0.0301099025982515 4662 54697379 SGTC_967 1306-0166 352 µM -1.88270703369293 0.0249443854747417 no 3229 0.0298700408576712 4639 4437607 SGTC_1415 3966-0071 78.1 µM -1.8891143649612 0.0245545661430039 no 3230 0.0294382530068121 4579 2893185 SGTC_1792 st045773 43.6 µM -1.89530788798799 0.0241826270547192 no 3231 0.0290258118813237 4634 2919270 SGTC_2829 7992743 58.44 µM -1.90104897712489 0.0238420954829325 no 3232 0.028647798884862 4627 16462845 SGTC_1521 st012942 49.4 µM -1.90327722781064 0.0237110174976224 no 3233 0.0285021903307183 4589 24207259 SGTC_1051 3253-3903 78 µM -1.90528533737934 0.0235934090483936 no 3234 0.0283714952016571 4665 5509239 SGTC_3027 9089541 49.47 µM -1.9073721002951 0.0234717143631053 no 3235 0.0282362097973658 4656 9943819 SGTC_869 0564-0080 44.1 µM -1.91095137480387 0.0232642100039885 no 3236 0.028005414994549 4653 6843321 SGTC_2711 st079103 59.1 µM -1.91298568159959 0.0231469631096935 no 3237 0.0278749427528019 4619 54693780 SGTC_183 3914-0051 30.55 µM -1.9159332935388 0.0229779610157648 no 3238 0.0276867935130792 4646 1596232 SGTC_1400 3771-8998 51.5 µM -1.92216130695582 0.0226242922810579 no 3239 0.0272927319220376 4655 670767 SGTC_1478 0453-0656 35.7 µM -1.9231891971562 0.0225663651777545 no 3240 0.0272281467303016 4699 5258496 SGTC_1220 1838-0075 193 µM -1.93482238217696 0.0219194439433088 no 3241 0.0265060477564751 4608 5529645 SGTC_3020 9089140 49.47 µM -1.93735973578984 0.0217804415047924 no 3242 0.0263506924424683 4675 17217859 SGTC_2115 tiliquinol 12.7705 µM -1.9414484077424 0.0215580208692407 no 3243 0.0261019557682273 4641 71208 A bioactive hydroxyquinoline. SGTC_361 000s-0510 1.45 µM -1.9519515759668 0.0209954394612806 no 3244 0.0254719770196042 4583 660 SGTC_3097 9117246 49.47 µM -1.95789404296736 0.0206826820367501 no 3245 0.0251212235295501 4682 16423892 SGTC_3061 glucosamine 200 µM -1.96443234344743 0.0203431333619843 no 3246 0.0247399875522173 4611 91431 and experimental redox chemotherapeutic SGTC_529 4076-0302 30.3 µM -1.96449829939478 0.0203397323389536 no 3247 0.024736166650209 4667 5816522 SGTC_1459 k035-0031 35.7 µM -1.96971739034049 0.0200721332623267 no 3248 0.0244353843932192 4462 3877128 YMR208W ERG12 SGTC_1845 st056753 3.01 µM -1.97224825887682 0.0199434466158412 no 3249 0.0242906365223887 4656 5375839 SGTC_1399 3562-5772 25 µM -1.97539079122496 0.0197846336445037 no 3250 0.0241119085158148 4675 23847490 SGTC_671 0560-0003 407 µM -1.9758298781394 0.0197625293751214 no 3251 0.0240870241240758 4676 3238678 SGTC_2619 obliquin 87.91 µM -1.98058256854866 0.0195246105686646 no 3252 0.0238190526817644 4652 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3040 9091894 49.47 µM -1.98888398632991 0.0191148779273382 no 3253 0.0233570048529996 4617 25236966 SGTC_2796 7949634 45.45 µM -1.99300321264085 0.0189142941629314 no 3254 0.0231305476472059 4643 2971588 SGTC_72 0744-0168 198.391 µM -2.01080141419845 0.0180680760891242 no 3255 0.0221732183532605 4600 677577 SGTC_3248 9135562 49.47 µM -2.01144055489319 0.0180382982377364 no 3256 0.0221394716638464 4666 17650701 SGTC_2053 5265679 138 µM -2.02092154796347 0.0176014649088012 no 3257 0.0216439434589689 4600 764595 SGTC_2775 cyproheptadine 69.59 µM -2.02835703179286 0.0172652249187233 no 3258 0.0212619110633554 4684 2913 A selective serotonin reuptake inhibitor. SGTC_1096 rimcazole 32.2 µM -2.03970145801248 0.0167627969305847 no 3259 0.0206900348112586 4672 18528119 A dopamine reuptake inhibitor. SGTC_1074 carmofur 3.8 µM -2.05090891749311 0.016278769364729 no 3260 0.0201379087832563 4740 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3002 9075603 71.4286 µM -2.05128553086144 0.0162627142775345 no 3261 0.0201195743537278 4658 20105405 SGTC_1231 0242-0792 125 µM -2.06296693899858 0.0157714252028945 no 3262 0.0195578847016681 4688 3707635 SGTC_2952 9073731 13.78 µM -2.06363049433924 0.0157439040621948 no 3263 0.0195263820101591 4667 16457353 SGTC_890 0929-0006 47.2 µM -2.0685063997246 0.0155429352128412 no 3264 0.0192962147236804 4701 1378169 SGTC_145 3737-0113 38.366 µM -2.07277840708413 0.015368670547417 no 3265 0.0190964534366766 4669 6849351 SGTC_1764 st044502 93.5 µM -2.08447935676491 0.0148999291606491 no 3266 0.0185582930229567 4712 8407 SGTC_3339 9145883 14.936 µM -2.09837641267297 0.0143592282657048 no 3267 0.0179359536183204 4662 2030670 SGTC_1167 k781-0610 148 µM -2.0989082824546 0.0143388746322559 no 3268 0.0179124933016035 4718 4525169 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -2.10414448145535 0.0141398181534955 no 3269 0.0176829228559225 4697 229346 A bile salt which induces apoptosis. SGTC_125 0133-0007 11.75 µM -2.10864626903012 0.0139705887083891 no 3270 0.0174875629622151 4758 26541 SGTC_1164 k060-0068 93.7 µM -2.11266298693787 0.0138210706503842 no 3271 0.01731481170897 4711 5963676 SGTC_2712 st079126 47.7 µM -2.11403372063191 0.0137703633632113 no 3272 0.0172561936674769 4710 3152970 SGTC_791 1348-1292 225 µM -2.11746537408529 0.0136441200880055 no 3273 0.0171101854974264 4703 5437054 SGTC_1781 st038725 66.3 µM -2.12098315338355 0.0135157462696867 no 3274 0.0169616100763734 4687 4270275 YIL048W NEO1 SGTC_404 fumagillin 50 µM -2.13911840852682 0.0128703546321603 no 3275 0.0162130399469136 4715 12015870 A methionine aminopeptidase binder. SGTC_3216 9129716 49.47 µM -2.13976643196885 0.0128477948370539 no 3276 0.0161868236439891 4632 8056934 SGTC_3090 9117696 49.47 µM -2.15639648461305 0.0122804369970889 no 3277 0.0155263594738528 4711 7923821 SGTC_2008 4012253 172 µM -2.16090153610251 0.0121305286317165 no 3278 0.0153514731148126 4701 603940 SGTC_19 0279-0214 38.434 µM -2.17284266376427 0.0117408312961109 no 3279 0.0148960805169761 4758 3566274 YBR002C RER2 SGTC_1309 pyrazolanthrone 13.4 µM -2.18400746188326 0.0113863449392807 no 3280 0.0144808498766277 4736 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2667 digitoxin 100 µM -2.19491716364029 0.0110489783730628 no 3281 0.0140847701927383 4730 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_672 1441-0018 53.7 µM -2.20330633970905 0.0107955014698937 no 3282 0.0137865822230884 4748 251141 SGTC_144 4161-2749 112.381 µM -2.21057065215419 0.0105801168241712 no 3283 0.0135327914633437 4736 797501 YMR168C CEP3 SGTC_1850 st056238 17 µM -2.21657575476371 0.0104049034016025 no 3284 0.0133260479446757 4730 5393177 SGTC_1770 st043884 66.3 µM -2.22246110037327 0.0102356437057585 no 3285 0.0131260800447591 4735 670149 SGTC_175 3793-3120 23.7 µM -2.23140804641346 0.00998293433955211 no 3286 0.0128270561746203 4702 5322297 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.24006642137078 0.00974357867496541 no 3287 0.0125433055409935 4704 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_38 0929-0051 58.268 µM -2.25030009555235 0.00946715259632564 no 3288 0.012214950941802 4701 1379719 SGTC_297 0986-0032 24 µM -2.25173655800161 0.00942890578524235 no 3289 0.0121694624757545 4719 2847425 SGTC_2802 7925815 54.55 µM -2.26397658269969 0.00910845135806615 no 3290 0.0117877775467374 4702 1262923 SGTC_1789 tunicamycin 25 nM -2.26871522128906 0.00898697419890246 no 3291 0.0116428246819644 4683 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2797 7859098 81.82 µM -2.27970066984327 0.00871080167772563 no 3292 0.0113127237796282 4697 972681 SGTC_2955 9076254 12.21 µM -2.30099678136204 0.00819654852865007 no 3293 0.0106959065050901 4710 16459619 SGTC_1233 0325-0408 14.2 µM -2.30359495335157 0.00813567111813998 no 3294 0.0106226957057702 4755 12874 SGTC_3052 9092717 49.47 µM -2.35300050377568 0.0070513167485209 no 3295 0.00931130443003978 4738 25237534 SGTC_2717 st081029 62.2815 µM -2.36417695928108 0.00682448053536674 no 3296 0.00903508945139845 4739 5292846 SGTC_1306 1185-0270 9.02 µM -2.37017692309208 0.0067053848736627 no 3297 0.0088897875359465 4765 1548076 SGTC_925 2064-1272 59.6 µM -2.40103847055648 0.00612136583207703 no 3298 0.00817430882524998 4734 6815817 SGTC_1629 st005085 44.9 µM -2.40574914387305 0.00603630346088048 no 3299 0.00806967141710323 4723 24207091 SGTC_939 1165-0479 45.3 µM -2.40666155031771 0.0060199494467462 no 3300 0.00804954093677757 4730 1377347 SGTC_1029 k015-0030 64.7 µM -2.44125560593042 0.00542815584154604 no 3301 0.00731814561740393 4760 2208316 SGTC_1684 st024538 14.6195 µM -2.44533510439208 0.00536189426516201 no 3302 0.00723588041942599 4763 6732859 SGTC_2970 9090938 41.86 µM -2.4610786545047 0.00511287153059693 no 3303 0.00692599973384726 4745 17217104 SGTC_2783 7738165 71.43 µM -2.46573610332636 0.00504120284573131 no 3304 0.00683660147513379 4730 17201110 SGTC_2950 9072895 21.46 µM -2.47005201933468 0.00497558970319229 no 3305 0.00675467028630413 4709 17332245 SGTC_816 0325-0417 81.3 µM -2.47047675128047 0.00496917397016666 no 3306 0.00674665446948131 4760 68101 SGTC_835 0312-0010 67.2 µM -2.47474747713533 0.00490507153124146 no 3307 0.00666652056025649 4775 1626196 SGTC_1027 k015-0025 8.67 µM -2.49759050589087 0.00457455596754488 no 3308 0.00625202708153906 4742 3598955 SGTC_2612 dictamnine 15.46 µM -2.54176209029408 0.00399131533845476 no 3309 0.00551476099096252 4713 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2923 7992654 58.14 µM -2.54938922770509 0.00389763866282897 no 3310 0.00539558933866606 4734 2985126 SGTC_1374 2889-5571 141 µM -2.55309021612808 0.00385289684700433 no 3311 0.00533859181880055 4751 2853281 SGTC_1493 4348-0038 111 µM -2.55317945724539 0.00385182370391542 no 3312 0.00533722408581884 4779 800424 SGTC_2827 7993847 71.43 µM -2.58454484251102 0.00349083150955325 no 3313 0.00487538119654345 4759 2985692 SGTC_946 3434-1334 87.4 µM -2.59273035204362 0.0034017655894582 no 3314 0.00476086963208186 4746 4047976 SGTC_2687 chenodiol 100 µM -2.61854119216269 0.0031341355428069 no 3315 0.00441533146302502 4766 5702181 A cholesterol synthesis inhibitor. SGTC_2659 sanguinarine 24.21 µM -2.62325393813564 0.00308736813638961 no 3316 0.00435471655311769 4761 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1504 k297-0033 30 µM -2.6404651266834 0.00292186221128826 no 3317 0.00413961564351509 4742 4388117 SGTC_2647 atorvastatin 60.16 µM -2.65000286436449 0.00283363033529876 no 3318 0.00402455442188016 4774 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2951 9072950 58.06 µM -2.7034501078669 0.00238219634678023 no 3319 0.00343118746388213 4739 16488155 SGTC_1806 st050005 60.3 µM -2.75759560778703 0.0019922309952943 no 3320 0.00291140913438526 4786 5194765 SGTC_1926 methyl fluorone black 53.6 µM -2.78266770997511 0.00183210216332846 no 3321 0.00269569963597049 4577 72721 Reacts with homocysteine. SGTC_945 3381-0768 11.3 µM -2.80078935122718 0.00172374952037347 no 3322 0.00254888915926291 4771 1126236 YIL048W NEO1 SGTC_1766 st045414 44.774 µM -2.8022338151929 0.00171536894219757 no 3323 0.0025375038705245 4776 253960 SGTC_1835 st008666 49.2 µM -2.80899573619972 0.00167662828199484 no 3324 0.00248481523833063 4775 690455 SGTC_2035 5154463 94.595 µM -2.82849588196518 0.0015693270982743 no 3325 0.00233836513843598 4789 2769623 SGTC_1805 st050013 60.3 µM -2.83326707822462 0.00154404476315368 no 3326 0.0023037436174349 4766 4037144 SGTC_900 1112-0045 141 µM -2.83576473150959 0.00153095844160697 no 3327 0.00228580546309413 4765 56211 YIL048W NEO1 SGTC_3060 1327-0027 12.5 µM -2.8407222111872 0.00150528316572076 no 3328 0.00225057509461112 4744 16000455 YPR107C YTH1 SGTC_2662 daunorubicin 22.37 µM -2.84390699891331 0.00148899670440006 no 3329 0.0022282026685951 4702 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2819 7996655 46.38 µM -2.90298790214489 0.00121459722149514 no 3330 0.00184810457551306 4778 6456960 SGTC_748 act1.228 77.9 µM -2.92452160978269 0.00112668788964884 no 3331 0.001724930627702 4780 4421505 YNR035C ARC35 SGTC_1296 1068-0102 11.9 µM -2.92875633823797 0.00111010152617476 no 3332 0.00170160544071469 4797 767053 SGTC_527 4476-4215 268 µM -2.93831672997534 0.00107347556604282 no 3333 0.00164999850301051 4788 4418754 SGTC_1633 st005664 67.9 µM -2.95830649797373 0.0010004491153622 no 3334 0.00154667192075582 4771 2063822 SGTC_1192 1488-0095 21.4 µM -2.96822988668962 0.000965916628012611 yes 3335 0.00149760113078848 4796 915875 SGTC_1846 st056244 14.8 µM -2.97190566976248 0.000953405505630952 yes 3336 0.00147978799703836 4784 5393182 SGTC_3196 9111891 49.47 µM -2.97581138669233 0.000940274982600969 yes 3337 0.00146107261382042 4771 18891510 SGTC_2713 st079149 53.4 µM -2.9838437485125 0.000913791778602851 yes 3338 0.00142326046794165 4790 3103253 SGTC_2576 guaiol 23.12 µM -3.00033845144407 0.000861543961911668 yes 3339 0.00134839882740434 4762 227829 SGTC_2834 9001755 58.44 µM -3.02511845357771 0.000788198119605443 yes 3340 0.00124267884011844 4700 2989575 SGTC_2570 licareol 100 µM -3.02914990501023 0.000776824235844913 yes 3341 0.00122621480894709 4774 443158 SGTC_1503 4585-0012 61.3 µM -3.05735283953762 0.00070138746805781 yes 3342 0.00111650628206415 4794 2922052 SGTC_1861 st057647 17.4 µM -3.07040617207478 0.000668811729008604 yes 3343 0.00106883920524999 4790 688668 SGTC_42 0133-0086 60.653 µM -3.12276954243218 0.00055167423217959 yes 3344 0.000895789859530289 4763 162923 Model of phenazepam hydroxylation. SGTC_1637 st007924 17.4 µM -3.22629332452689 0.000373886982839414 yes 3345 0.000627023823320818 4776 683336 SGTC_2888 9058547 12.99 µM -3.31604279594328 0.000264469229465361 yes 3346 0.000456509230392936 4785 16476514 SGTC_3283 9109332 35.8195 µM -3.50390516294127 0.000124698836274441 yes 3347 0.000229244303914032 4772 17027281 SGTC_750 4073-0104 132 µM -3.53827850385832 0.000108240919023852 yes 3348 0.000201372509622422 4710 22330957 SGTC_289 k017-0060 526 µM -3.67789677882455 6.01443563833455e-05 yes 3349 0.000117582542152785 4807 5512909 SGTC_2936 9038235 15.59 µM -3.85512114096945 2.77003715277112e-05 yes 3350 5.78361682433489e-05 4793 4749415 SGTC_3153 9100258 49.47 µM -3.97400314633643 1.61654704435905e-05 yes 3351 3.53373142970972e-05 4794 25236848 SGTC_3050 9093513 49.47 µM -3.98971810601401 1.50378566412432e-05 yes 3352 3.30759333153704e-05 4802 25236664 SGTC_66 0109-0187 42.4 µM -4.15309192719777 6.98268630711798e-06 yes 3353 1.6400644535187e-05 4765 759417 SGTC_2933 9026794 32.47 µM -4.21706937215959 5.13120004885333e-06 yes 3354 1.23748926334246e-05 4804 17586027 SGTC_1107 amlodipine 47 µM -4.5773281047428 8.34841256545979e-07 yes 3355 2.3547624709048e-06 4692 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_744 1594-0068 283 µM -5.58744734073689 2.4546830638554e-09 yes 3356 1.15215799473189e-08 4810 668392