SGTCid condition conc unit SPT23|YKL020C.score SPT23|YKL020C.strain.pval SPT23|YKL020C.strain.significant SPT23|YKL020C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1941 st076221 61.8 µM 7.08059010081914 1.60611856320366e-14 yes 1 7.17709499801063e-13 26 2828568
SGTC_103 0844-0104 51.839 µM 6.85813444406035 9.83777873165029e-14 yes 2 3.48827939532204e-12 62 5375804
SGTC_2991 9074669 71.4286 µM 6.21483826749902 1.3567774711966e-11 yes 3 2.56887702046022e-10 19 17333109
SGTC_3203 9113543 49.47 µM 6.17282910263657 1.84154560745974e-11 yes 4 3.35393534294742e-10 4 17018012
SGTC_3210 9128157 49.47 µM 5.48961779439606 2.0040851360359e-09 yes 5 2.01402205966409e-08 19 17590849
SGTC_1500 4488-1866 171 µM 5.17605617116033 1.44725801958506e-08 yes 6 1.13312626425992e-07 4 2900003
SGTC_2874 9043904 71.43 µM 5.01442165469165 3.841501021781e-08 yes 7 2.65966105143973e-07 2 4463428
SGTC_3304 9125678 46.087 µM 4.76605006803404 1.62663534654737e-07 yes 8 9.39362960958799e-07 26 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_266 formosanin C 406 nM 4.76545564444032 1.63212902601007e-07 yes 9 9.42136735680644e-07 51 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3204 9114183 49.47 µM 4.67534609089165 2.70864824824454e-07 yes 10 1.46729147255708e-06 16 17027248
SGTC_935 2996-0153 430 µM 4.66742472733652 2.83077069081515e-07 yes 11 1.52499215492134e-06 10 23738523
SGTC_3048 9093155 49.47 µM 4.58394966552355 4.4862905477406e-07 yes 12 2.28137058808698e-06 2 25236002
SGTC_2598 perillyl alcohol 100 µM 4.45848658627732 8.83366072202247e-07 yes 13 4.12701806175801e-06 19 10819 An apoptosis inducer.
SGTC_1161 k007-0610 110 µM 4.4092223423683 1.14711976585903e-06 yes 14 5.18712364243755e-06 100 5843850
SGTC_723 4182-0001 115 µM 4.39141108468764 1.25992618402677e-06 yes 15 5.6308694339504e-06 22 744821 YLR208W SEC13
SGTC_1087 pterostilbene 9.05 µM 4.36876694389822 1.41877791723727e-06 yes 16 6.24750102945025e-06 18 5281727 Similar to reservatol, lowers cholesterol.
SGTC_834 0312-0008 75.7 µM 4.27613831135889 2.29244082831802e-06 yes 17 9.50815528734428e-06 25 6385573 YIL048W NEO1
SGTC_2607 solasodine 47.35 µM 4.27083516718922 2.35561152885957e-06 yes 18 9.73711537119047e-06 49 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2035 5154463 94.595 µM 4.26504661437718 2.4264669292669e-06 yes 19 9.99302353633407e-06 10 2769623
SGTC_2997 9067075 71.4286 µM 4.18527096364523 3.63676410751783e-06 yes 20 1.42413066156764e-05 49 27209819
SGTC_2621 lithochol-11-enic acid 100 µM 4.10489949454222 5.42852109071066e-06 yes 21 2.02245349653555e-05 20 6708711
SGTC_2788 5282734 71.43 µM 4.07401625566147 6.31983875818462e-06 yes 22 2.31046270125894e-05 42 743706
SGTC_2858 9025781 8.96 µM 3.9074975606333 1.40876469223192e-05 yes 23 4.66284913744398e-05 102 4894980 YPL153C RAD53
SGTC_928 2764-0428 58.7 µM 3.89728003626872 1.47831934837406e-05 yes 24 4.86395550860799e-05 60 662578
SGTC_115 0527-0192 112.043 µM 3.89255158695988 1.51160128769264e-05 yes 25 4.95976989549937e-05 73 4233931
SGTC_1994 st072947 40.9 µM 3.88089450066003 1.59671983226543e-05 yes 26 5.2036491033495e-05 20 5286565 YDL195W SEC31
SGTC_1493 4348-0038 111 µM 3.84896886995456 1.85376727698161e-05 yes 27 5.93080394077367e-05 32 800424
SGTC_423 5-fluorouracil 457 µM 3.84124732314532 1.92159191467139e-05 yes 28 6.12053502954662e-05 26 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2112 5488546 200 µM 3.74171678173848 3.03583256074358e-05 yes 29 9.1383711700254e-05 23 600757
SGTC_1715 st032160 10.2275 µM 3.6977443240875 3.70274868855094e-05 yes 30 0.000108761908860761 48 5289825
SGTC_2594 a-mangostin 100 µM 3.62474229771666 5.12482028745065e-05 yes 31 0.000144624864625065 37 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_664 1222-0054 14.9 µM 3.59833008468187 5.75605490290732e-05 yes 32 0.000160133491699306 44 6813991
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 3.49764524092617 8.9000939817702e-05 yes 33 0.000234692526058371 48 5379071
SGTC_3060 1327-0027 12.5 µM 3.45689085429992 0.000105837722572419 yes 34 0.00027322306264293 46 16000455 YPR107C YTH1
SGTC_1836 st055642 81 µM 3.43665673911914 0.000115267632357509 yes 35 0.000294470740030848 36 8571
SGTC_105 0111-0055 734.78 µM 3.3752308387215 0.000148952645221312 yes 36 0.000368768992675107 16 5179370
SGTC_2619 obliquin 87.91 µM 3.37359358250966 0.000149965560862487 yes 37 0.000370969110292727 188 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1694 st024011 44.9 µM 3.26986213211249 0.000229030559687284 yes 38 0.000537999564278786 67 2787533
SGTC_373 0844-0104 25.9 µM 3.20231219002114 0.000299865250699057 yes 39 0.000681645821033806 91 5375804
SGTC_2517 totarol 10 µM 3.16405179896191 0.000348547706157944 yes 40 0.000777945507025079 48 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1358 1509-0022 2.48 µM 3.14360111576513 0.000377488202771337 yes 41 0.000834413742281461 38 3258434
SGTC_2797 7859098 81.82 µM 3.09786195076721 0.000450474725507607 yes 42 0.000974611025935971 63 972681
SGTC_1835 st008666 49.2 µM 3.04074475789677 0.000559961235772807 yes 43 0.00117996897557695 55 690455
SGTC_2878 9043973 25.97 µM 3.02577559971446 0.000592473084193225 yes 44 0.00123998140009956 49 6465167
SGTC_531 3788-1495 174 µM 3.01283133291913 0.000621984059653362 yes 45 0.00129411362527361 68 2896655
SGTC_2069 5228469 200 µM 3.01226768550173 0.000623299416742857 yes 46 0.00129651913833156 52 2835210
SGTC_1706 st031321 9.9705 µM 2.99483677036609 0.000665267452789199 yes 47 0.00137295872099263 41 6103185
SGTC_1077 5-fluorocytosine 377 nM 2.98245425478435 0.000696648033083663 yes 48 0.00142973688772207 50 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1373 2887-0003 58.5 µM 2.95267185634682 0.000777795693534726 yes 49 0.00157518327457982 66 776948
SGTC_2780 5215298 71.43 µM 2.92487949687859 0.000861285369200249 yes 50 0.00172294815995432 101 2834131
SGTC_2446 5162541 200 µM 2.9233274634477 0.000866182309255048 yes 51 0.0017315604726168 41 1549321
SGTC_2096 5468907 200 µM 2.87966554687466 0.00101488664541974 no 52 0.00199048617540245 41 759785
SGTC_38 0929-0051 58.268 µM 2.86959920224875 0.00105233874000943 no 53 0.002054961940155 83 1379719
SGTC_3059 1327-0034 3 µM 2.86588438764589 0.00106647702526953 no 54 0.00207923041484356 105 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1934 st074720 32.6 µM 2.86437917601233 0.00107225516163952 no 55 0.00208913760598439 119 17250992
SGTC_2247 cerulenin 830 nM 2.84132982453923 0.00116439622177816 no 56 0.00224629109996006 69 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.81937890638149 0.00125883194564385 no 57 0.00240583411070855 78 115019
SGTC_766 1391-0721 126 µM 2.8151043362607 0.0012780173439066 no 58 0.00243806999952306 75 1020919 YIL115C NUP159
SGTC_1899 st063254 59.6 µM 2.80334689955793 0.00133217528606793 no 59 0.00252876190480503 51 3093813
SGTC_3288 9119690 36.221 µM 2.79537509955167 0.00137008015277819 no 60 0.00259197643354818 62 17595618 YKL019W RAM2
SGTC_2335 9018011 154.17 µM 2.78020595415299 0.00144494078728621 no 61 0.0027162216438537 89 6458208
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 2.77021337030776 0.00149627506243146 no 62 0.00280097908096239 79 4330530
SGTC_2301 7769476 200 µM 2.76781631231502 0.0015088342210332 no 63 0.00282166263503776 65 977820
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.73152678669537 0.00171109054485606 no 64 0.00315208080280491 101 65057 A dermal irritant. YDR527W RBA50
SGTC_2074 5212007 75.395 µM 2.70650353309537 0.001864613404025 no 65 0.00339979294291209 62 758611
SGTC_2986 9022445 71.43 µM 2.69214873441338 0.00195823428247209 no 66 0.00354966383729412 92 6459286
SGTC_2089 5281248 129.67 µM 2.69155366351738 0.00196220588222135 no 67 0.00355600277165005 91 2737878
SGTC_2784 7567673 72.73 µM 2.6728312649061 0.00209095948331442 no 68 0.00376070361169591 112 3471247
SGTC_2767 sibutramine 71.45 µM 2.64945295383939 0.00226247262671306 no 69 0.00403110981527503 96 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1974 st069448 26.9 µM 2.63966132534254 0.00233802057540597 no 70 0.00414944572141658 86 6323587 YNR016C ACC1
SGTC_788 1182-0090 188 µM 2.63390638273855 0.00238348172041595 no 71 0.00422043788384651 197 5715185
SGTC_3120 9124077 49.47 µM 2.61164201164354 0.0025669904896555 no 72 0.00450542774710026 71 18774327 YGL155W CDC43
SGTC_1118 chelidonine 707.474 nM 2.61073639914297 0.00257471806671723 no 73 0.00451737520638277 99 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1834 st055981 52.8 µM 2.60602738700816 0.00261523988806332 no 74 0.00457995686276874 111 471719 YDL150W RPC53
SGTC_568 1193-0097 7.48 µM 2.5636390718368 0.00300676302365203 no 75 0.00517905974030251 267 3646150
SGTC_1594 piperine 70.1 µM 2.55853130697964 0.00305734321325144 no 76 0.00525576774127097 114 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3104 9120930 49.47 µM 2.55320471172821 0.00311090546487795 no 77 0.00533683708550149 88 17014836
SGTC_2967 9089538 49.85 µM 2.53983598938026 0.00324907638594173 no 78 0.00554522315579392 130 728216
SGTC_1054 3429-0080 167 µM 2.53889973374766 0.00325895671552757 no 79 0.00556008438341843 118 1162877
SGTC_2690 usnic acid 100 µM 2.53881123618698 0.00325989202907458 no 80 0.00556149093759993 127 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1676 st018489 23.4 µM 2.52714107163367 0.00338536760183984 no 81 0.00574976504667626 133 3696235
SGTC_2086 5274770 176.623 µM 2.49423589586233 0.00376286108530797 no 82 0.00631143118896085 127 689278
SGTC_1750 st081859 2.357 µM 2.46795553915688 0.00409101031384292 no 83 0.00679435982645649 344 5291695
SGTC_2298 7976326 193.81 µM 2.45810359328526 0.00422047987664321 no 84 0.00698364389590912 80 2235818
SGTC_733 4069-0007 56.1 µM 2.43580097809569 0.00452719909647419 no 85 0.00742942868956722 221 5717425 YNL287W SEC21
SGTC_400 oxethazaine 37.5 µM 2.43121452587363 0.00459268851187984 no 86 0.00752415083859773 112 4621 A local anesthetic.
SGTC_2627 acetyl isogambogic acid 100 µM 2.43001702190242 0.00460992614839107 no 87 0.00754905686716838 165 6857789 A caspase activator and apoptosis inducer.
SGTC_3324 9138759 60.749 µM 2.41220420222482 0.00487324043000117 no 88 0.00792819898907238 118 45595710
SGTC_1728 st035614 33.7865 µM 2.40461113430085 0.0049895006044833 no 89 0.00809484139674532 203 15945546
SGTC_1126 isoteolin 1.0172 µM 2.40276091204348 0.00501820171721172 no 90 0.00813591106906109 155 133323
SGTC_2029 5175081 200 µM 2.39871187135784 0.00508152499292893 no 91 0.0082264275889185 147 1380876
SGTC_3064 1327-0027 10 µM 2.38548803500816 0.00529331824030462 no 92 0.0085282386041358 58 16000455 YPR107C YTH1
SGTC_1714 st033236 13.627 µM 2.38270767470561 0.00533883484187219 no 93 0.00859291766327707 146 2916566
SGTC_2564 betulinic acid 100 µM 2.36252351176819 0.00567983038050206 no 94 0.00907549501991903 174 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3272 9137413 49.47 µM 2.36026118451462 0.00571923077358713 no 95 0.00913103620685046 120 17614870
SGTC_1296 1068-0102 11.9 µM 2.33354572431269 0.00620318284541044 no 96 0.00980976071576609 121 767053
SGTC_2123 5259487 200 µM 2.30839004478073 0.00669168074465686 no 97 0.010488726099536 144 2173474
SGTC_2428 5615643 7.78 µM 2.3037529679002 0.00678535011501322 no 98 0.010618257315666 144 2253075
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 2.29447427394755 0.00697626483596308 no 99 0.0108816355621287 54 1241132 A phosphatase inhibitor.
SGTC_3128 9127691 49.47 µM 2.2919866693394 0.00702824822230441 no 100 0.0109532062131899 130 41316314
SGTC_358 0075-0058 9.45 µM 2.27312914280575 0.00743355636527698 no 101 0.0115091993479362 255 1069125
SGTC_2972 9093619 59.92 µM 2.267268557875 0.0075636461753106 no 102 0.0116869124913299 158 25236256
SGTC_701 4424-0219 185 µM 2.2595080087038 0.00773899341095469 no 103 0.0119259013495674 154 2911779
SGTC_737 1950-0117 57.9 µM 2.24507164232705 0.00807471552779193 no 104 0.0123817668673744 157 5393513
SGTC_2451 5856223 45.7 µM 2.23776069182603 0.00824956658340749 no 105 0.0126183325230348 156 2179896
SGTC_154 3389-1638 511.116 µM 2.22397368525971 0.00858836812109959 no 106 0.01307510738701 166 5238686
SGTC_604 1000-0114 314 µM 2.21275245132257 0.00887306732956677 no 107 0.0134573585307903 167 1572745
SGTC_1644 st010134 20.9 µM 2.21072105059373 0.00892548183905705 no 108 0.0135275799412248 122 3818134
SGTC_2075 5212009 200 µM 2.20064133003425 0.00918959248962623 no 109 0.0138807126356001 123 780898
SGTC_1628 st004252 77.7 µM 2.18902506057402 0.00950242654634652 no 110 0.0142975092991257 186 692968
SGTC_532 1548-0774 215 µM 2.17897702909124 0.00978049768881642 no 111 0.0146666873556595 172 5932993
SGTC_1872 amphotericin b 148 nM 2.17465775316046 0.00990219806276344 no 112 0.0148278864890906 170 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1891 st059073 26.2 µM 2.15958011644762 0.0103374507763241 no 113 0.0154025945279688 184 688754
SGTC_661 1304-0007 33.6 µM 2.15957894406326 0.0103374852584415 no 114 0.0154026399485107 162 3117130
SGTC_2719 novobiocin 32.65 µM 2.15879052329648 0.0103606969770906 no 115 0.0154332110179905 84 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1071 trifluoperazine 6.31 µM 2.14708422007195 0.0107107232477713 no 116 0.0158932886647217 192 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_865 0488-0499 301 µM 2.14284846506183 0.010839888580849 no 117 0.0160626341167041 156 9634651
SGTC_2444 5485484 36.41 µM 2.14080734453568 0.0109026132350349 no 118 0.0161447887231261 219 6790631
SGTC_2336 9001819 198.65 µM 2.13671411393206 0.0110293526570398 no 119 0.016310625668602 240 2989602
SGTC_287 k060-0039 29.6 µM 2.13358277874547 0.0111271721039104 no 120 0.0164384744597662 156 5861974
SGTC_2846 9008642 19.48 µM 2.12916405051715 0.0112664913354212 no 121 0.0166203450215767 167 2992898
SGTC_759 3486-0358 89.3 µM 2.12656783094412 0.0113490533457293 no 122 0.0167280038662964 192 875103
SGTC_805 3852-0218 479 µM 2.10957665168438 0.0119024780829613 no 123 0.017447418601594 236 6615355
SGTC_3053 9095903 49.47 µM 2.09701597109882 0.0123265058703335 no 124 0.0179960807802601 117 17174018
SGTC_3188 9110789 49.47 µM 2.0950119321918 0.0123953555281762 no 125 0.0180849658930734 204 849217
SGTC_1687 st020778 55.3625 µM 2.08872484413314 0.0126135171662428 no 126 0.0183662495582858 389 4259299
SGTC_992 3909-8734 162 µM 2.08548185095443 0.0127273425588964 no 127 0.0185127919498295 183 4288319
SGTC_107 0358-0022 2.6945 µM 2.07990977592736 0.0129249920756272 no 128 0.018766904596293 122 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3032 9089427 49.47 µM 2.07716394879184 0.0130233629663408 no 129 0.0188932149999749 175 17173707
SGTC_2552 juarezic acid 87.02 µM 2.06673099191014 0.0134030541582246 no 130 0.0193797545760116 238 1549512
SGTC_2933 9026794 32.47 µM 2.06327833238008 0.0135307958841468 no 131 0.0195430957413176 222 17586027
SGTC_2122 5258151 111.688 µM 2.06175888362086 0.0135873447183271 no 132 0.0196153486919458 210 2173356
SGTC_3169 9102970 49.47 µM 2.06168242272152 0.0135901957211022 no 133 0.0196189905533734 124 17027839
SGTC_36 0335-0881 14.2 µM 2.05318487552318 0.0139102783189558 no 134 0.0200273253506865 313 23828853
SGTC_747 3448-8087 38.7 µM 2.05165145092761 0.013968725898886 no 135 0.0201017740608453 235 5168703
SGTC_3334 9142812 21.919 µM 2.05157604195409 0.0139716056195856 no 136 0.0201054412602485 210 45283678
SGTC_2988 9073640 71.4286 µM 2.04469777186296 0.0142364346358406 no 137 0.020442331718925 196 9102229
SGTC_2889 9059656 51.95 µM 2.04090664393842 0.0143842417833328 no 138 0.0206300536533887 181 3949838
SGTC_1765 st044815 90.4 µM 2.03412261406837 0.0146520342764877 no 139 0.0209696172177735 214 645695
SGTC_460 trequinsin 123 µM 2.03064443237163 0.0147909875697608 no 140 0.0211455384916397 132 5537 A vasodilator.
SGTC_2694 st077685 81.9 µM 2.0302478442151 0.0148069030085077 no 141 0.0211656764010722 234 2838096
SGTC_1979 st071809 45.3 µM 2.02398000499586 0.0150603995407328 no 142 0.0214861045531277 185 4976333
SGTC_2026 5148700 152 µM 2.02077530411911 0.0151914453393082 no 143 0.021651515197369 213 79838
SGTC_2604 4'-hydroxychalcone 11.32 µM 2.0168906746071 0.0153516069364405 no 144 0.0218534617306734 221 5282362
SGTC_1280 0880-0253 10.1 µM 2.01527443471493 0.0154186697254036 no 145 0.0219379510428242 220 6836607
SGTC_2078 5212016 200 µM 2.00586556894865 0.0158140872117602 no 146 0.0224352963227832 169 1899708
SGTC_1660 st012960 28.1 µM 2.00481027144386 0.0158589749257326 no 147 0.0224916670228484 241 24207266
SGTC_1860 st056228 74.6 µM 1.99868470002191 0.0161216932000736 no 148 0.0228212397318218 211 688679
SGTC_2691 st077356 60.2 µM 1.99552759703024 0.0162585478298114 no 149 0.0229926836722094 235 2839272
SGTC_1658 st012944 20 µM 1.99364231817141 0.0163407448209741 no 150 0.0230955786007176 253 24207260
SGTC_794 k038-0031 316 µM 1.99353218637995 0.0163455574810386 no 151 0.0231016013518575 324 6624242
SGTC_48 0382-0018 55 µM 1.99207189324683 0.0164094858153776 no 152 0.0231815851600437 185 762596
SGTC_1023 4482-3888 16 µM 1.98496554151019 0.0167236501824352 no 153 0.0235741527052668 209 3303168
SGTC_1150 3909-7983 10.9 µM 1.98176143848317 0.0168669747719801 no 154 0.0237529736181663 258 23965914
SGTC_2838 9002687 71.43 µM 1.9731057179927 0.0172594209885912 no 155 0.0242417594800384 220 6457060
SGTC_2905 7799065 20.05 µM 1.97035113826548 0.0173859373757418 no 156 0.0243990706854503 182 1296806
SGTC_2346 9031566 143.75 µM 1.96672689726232 0.0175536027153521 no 157 0.0246073521323255 203 4771086
SGTC_1942 st076330 65.2 µM 1.96467847443026 0.0176489763490164 no 158 0.0247257314314589 241 24208414
SGTC_3260 9137109 49.47 µM 1.96298601266109 0.0177281099010729 no 159 0.024823899665769 142 17478346
SGTC_3043 9092303 49.47 µM 1.96263919482488 0.017744363203124 no 160 0.0248440565221342 212 25236084
SGTC_55 0767-0285 6.563 µM 1.96064074824014 0.0178382664865673 no 161 0.0249604727222535 286 3116166
SGTC_2171 5739187 198.077 µM 1.95699932757456 0.0180104601204127 no 162 0.0251737737067443 184 2262761
SGTC_808 0711-0032 135 µM 1.95479814834822 0.0181152340730482 no 163 0.0253034499111871 202 4252555
SGTC_705 1124-0212 310 µM 1.95364049697831 0.0181705452976954 no 164 0.0253718739080357 240 9554485
SGTC_1390 3413-2614 145 µM 1.94150376225435 0.0187591398311099 no 165 0.0260986017639273 264 3421432
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.93788240225172 0.0189378773023058 no 166 0.0263187857011193 302 688788
SGTC_2126 5251174 33.877 µM 1.93724691037298 0.0189693918644071 no 167 0.0263575842336937 318 790722
SGTC_938 3126-1755 342 µM 1.93665747715415 0.018998662201469 no 168 0.0263936134810548 217 1777771
SGTC_2001 4023502 57.655 µM 1.93400442186938 0.0191308847870654 no 169 0.0265562920887465 257 108941 YCR052W RSC6
SGTC_3248 9135562 49.47 µM 1.93362106091378 0.019150055215643 no 170 0.0265798679323657 224 17650701
SGTC_1724 st037281 8.293 µM 1.92853961752455 0.0194057057209383 no 171 0.0268940207024841 274 574124 YDL195W SEC31
SGTC_2228 7354201 200 µM 1.91953025736811 0.0198661015505581 no 172 0.0274586304147267 171 753451
SGTC_829 1635-0120 117 µM 1.91740813101258 0.019975885140181 no 173 0.0275930510305863 279 285054
SGTC_1184 1269-1718 139 µM 1.9168310737398 0.0200058268006408 no 174 0.0276296979452203 220 5403821
SGTC_1195 1502-0147 41.1 µM 1.91083797925069 0.0203190466283893 no 175 0.0280127026684314 265 817940
SGTC_226 1,3-diallylurea 8.28947 mM 1.89386618109724 0.0212286902552362 no 176 0.0291213872088744 221 74537 YKL182W FAS1
SGTC_559 1550-0661 158 µM 1.89228450332852 0.0213151918445836 no 177 0.0292265422719568 236 5830875
SGTC_302 1094-0063 18.9 µM 1.89216219425687 0.0213218932968875 no 178 0.0292346868959985 187 5440289
SGTC_377 3970-0964 33.1 µM 1.88550298242299 0.0216894577344544 no 179 0.0296809810849324 359 16481235
SGTC_2827 7993847 71.43 µM 1.88400118772737 0.0217730871155888 no 180 0.0297824074057074 209 2985692
SGTC_2927 9011802 47.9 µM 1.8836305980676 0.0217937657285755 no 181 0.0298074800086644 266 43912568
SGTC_2258 7960471 200 µM 1.87623754316981 0.022209771503164 no 182 0.0303113344876705 188 2974708
SGTC_2703 st077852 53.4 µM 1.87517350631912 0.0222701927187449 no 183 0.0303844288529352 259 6281836
SGTC_1320 1313-0481 95.3 µM 1.8726683841631 0.0224129936074785 no 184 0.0305570958809324 248 6813365 YLR208W SEC13
SGTC_2763 lisinopril 49.32 µM 1.86980427991369 0.0225772032004651 no 185 0.030755500910265 206 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2138 5575593 77.673 µM 1.86652155310774 0.0227666603204767 no 186 0.0309842157400624 207 762213
SGTC_1959 st077091 55.8 µM 1.86504793066601 0.0228521426945386 no 187 0.0310873430490249 299 821356 YKL052C ASK1
SGTC_405 ebelactone b 50 µM 1.85642027186131 0.0233580627206695 no 188 0.0316968387329292 267 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2532 xanthone 78.9 µM 1.85339629764567 0.0235376029105277 no 189 0.0319127888054009 263 7020 An insecticide.
SGTC_1838 st055369 84.5 µM 1.85251119835269 0.0235903723563474 no 190 0.0319762255070482 235 676036
SGTC_424 splitomicin 100 mM 1.84798185163061 0.0238619710401148 no 191 0.0323024841445206 261 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1059 3448-6867 171 µM 1.84489144806632 0.0240487892334896 no 192 0.0325266654758657 255 3934407
SGTC_1923 st058458 19.1 µM 1.84319948510902 0.0241515897483078 no 193 0.0326499450280856 324 3534982
SGTC_2899 9053889 58.44 µM 1.83839230722205 0.0244456810744101 no 194 0.0330023089371042 207 6470052
SGTC_683 panaxydol 45 µM 1.83599031708866 0.0245937516138164 no 195 0.033179544369283 285 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1046 2001-0062 216 µM 1.83591030931333 0.0245986966121417 no 196 0.0331854613630644 279 739778
SGTC_3130 9127414 49.47 µM 1.82696607125119 0.0251567927923359 no 197 0.0338524354556753 242 1494646
SGTC_2244 6635614 200 µM 1.82503902880756 0.0252784143778976 no 198 0.0339975699508656 156 836499
SGTC_1434 4073-0095 163 µM 1.82161313008728 0.0254958498196709 no 199 0.0342568536236159 256 24133745
SGTC_2420 aureobasidin a 50 nM 1.82125186810648 0.0255188694666892 no 200 0.0342842896425221 343 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.81709582153638 0.0257849472300667 no 201 0.0346012212330005 277 390807
SGTC_2515 chrysin 20.77 µM 1.80832698676352 0.0263539666501358 no 202 0.0352778120503897 251 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_883 0850-0245 24.6 µM 1.80691210128299 0.0264467563213149 no 203 0.0353879927037842 312 6823229 YPR165W RHO1
SGTC_1457 k015-0032 57.3 µM 1.80262281921547 0.026729721757052 no 204 0.0357237353900901 315 4302660
SGTC_352 k048-0007 5.11 µM 1.79821969760988 0.0270228227508727 no 205 0.0360710996423894 343 6811911
SGTC_1187 1391-0724 117 µM 1.79426167116493 0.0272885799567695 no 206 0.0363857063871433 316 6997986
SGTC_1043 0916-0009 19.3 µM 1.78905967055728 0.0276411745360329 no 207 0.0368026031173555 353 3101130
SGTC_791 1348-1292 225 µM 1.78806997725526 0.0277086846240083 no 208 0.0368823593260878 375 5437054
SGTC_2524 avocatin b 10.57 µM 1.78730342483618 0.0277610679512604 no 209 0.0369442303979337 244 6710748
SGTC_558 k064-0027 21.3 µM 1.78607180007252 0.0278454053706228 no 210 0.0370438167189395 297 5088526
SGTC_1437 4092-1038 11.6 µM 1.78268237989159 0.0280786038038593 no 211 0.0373190105969649 296 3977136
SGTC_481 bay k-8644 50 µM 1.78234103441392 0.0281021788811544 no 212 0.0373468174521501 279 2303 A calcium channel antagonist.
SGTC_2636 apigenin dimethyl ether 100 µM 1.77667822997354 0.028495691972742 no 213 0.0378105980675872 348 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_540 1187-0821 17.3 µM 1.77284803721986 0.0287644458105872 no 214 0.0381269455062203 289 847520
SGTC_563 tetrahydrosecaminediol 614 µM 1.76979993848023 0.0289798252666316 no 215 0.0383802370748901 305 334274 A psychoactive constituent of the cannabis plant.
SGTC_2811 7967822 32.47 µM 1.76814934037257 0.0290970152636281 no 216 0.0385179703549438 305 2232244
SGTC_734 2023-0417 80 µM 1.75306796935185 0.0301861113232539 no 217 0.0397951704072724 319 3935732
SGTC_2437 5741531 144.16 µM 1.74511357549402 0.0307740136696196 no 218 0.0404825504783504 328 2262990
SGTC_1514 1189-1591 158 µM 1.74074139382414 0.0311011746327467 no 219 0.0408644594869983 377 767698 YMR146C TIF34
SGTC_743 1275-0778 158 µM 1.74063655017726 0.0311090550496724 no 220 0.0408736533167709 336 2849257 YMR203W TOM40
SGTC_1314 1222-0010 41.1 µM 1.73578584866514 0.0314754610424499 no 221 0.0413008536111673 286 3526027
SGTC_275 trichlorophene 5.69 µM 1.73272297708004 0.0317086525125293 no 222 0.0415724592748953 533 62616
SGTC_1578 josamycin 24.2 µM 1.72624245476718 0.0322067535325899 no 223 0.0421519015861125 298 5282165 A P450 substrate.
SGTC_2768 sulfasalazine 50.2 µM 1.72298763115309 0.0324593494837771 no 224 0.0424453809067599 295 5384001 An antioxidant and salicylic acid derivative.
SGTC_2620 irigenin 100 µM 1.71901506491025 0.0327698594769834 no 225 0.0428058144200182 352 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1355 1499-0035 1.68 µM 1.71287034655273 0.0332549730700707 no 226 0.0433681973732915 316 1548538
SGTC_2699 st077704 54.6 µM 1.71197112812013 0.0333264582640588 no 227 0.043450994645697 335 645852
SGTC_744 1594-0068 283 µM 1.70605288825268 0.0338001040599678 no 228 0.0439991164932635 377 668392
SGTC_2450 5739737 12.93 µM 1.70270076436064 0.0340708274331181 no 229 0.0443120408836785 315 2262825
SGTC_2407 paclitaxel 400 µM 1.69888845992844 0.0343808800939613 no 230 0.0446701008871204 376 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2856 9022925 19.48 µM 1.69872667943265 0.0343940887307978 no 231 0.044685347057389 338 4944862
SGTC_2251 lansoprazole 556 µM 1.68150732041466 0.0358239954991313 no 232 0.0463322078744518 255 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3024 9090631 49.47 µM 1.68118993200699 0.0358508020022685 no 233 0.0463630142343136 261 25236383
SGTC_1392 3455-1037 33.9 µM 1.67947090809271 0.0359962757983203 no 234 0.0465301520052663 323 981132
SGTC_651 3253-0966 34.4 µM 1.67845343819752 0.0360826075574995 no 235 0.0466293064701609 362 781462
SGTC_204 PMA1.184 62.41 µM 1.67569059771143 0.0363178886854294 no 236 0.0468994062262347 362 2252213 YGL008C PMA1
SGTC_1192 1488-0095 21.4 µM 1.66853155456559 0.0369333940051657 no 237 0.0476051266711755 321 915875
SGTC_1055 3448-0672 86 µM 1.66484171985653 0.0372539461047345 no 238 0.0479721690238393 347 748378
SGTC_2127 5253358 187.912 µM 1.66177385531265 0.0375221923491642 no 239 0.0482790631345061 321 20612
SGTC_95 0471-0001 561.058 µM 1.66079810422392 0.03760783939894 no 240 0.0483770010247929 359 4015405
SGTC_1329 1447-1697 50.6 µM 1.65779764196167 0.0378722070049141 no 241 0.0486791587203606 349 2840515
SGTC_2165 5727197 32.143 µM 1.65766256202825 0.0378841443398276 no 242 0.0486927971787566 353 1361712
SGTC_2330 7979373 200 µM 1.65494982623012 0.038124525913465 no 243 0.0489673379615875 376 1863007
SGTC_2380 9035439 200 µM 1.6532118010652 0.0382791890127001 no 244 0.0491438827850128 383 6462575
SGTC_2685 mycophenolic acid 18.85 µM 1.65318487849828 0.0382815888114486 no 245 0.0491466215140158 281 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_725 1497-0963 19 µM 1.64712146477657 0.0388251967396872 no 246 0.0497665409961963 335 3549977
SGTC_3294 9122953 26.2835 µM 1.64011914418796 0.0394607869826703 no 247 0.0504901983238974 358 16459826
SGTC_1176 0848-0131 83.3 µM 1.63918562170234 0.0395461572783803 no 248 0.0505873036873145 375 6769040
SGTC_300 r073-0011 5.04 µM 1.63198654687822 0.0402095674938974 no 249 0.0513411601368808 399 2735780
SGTC_672 1441-0018 53.7 µM 1.62520460011635 0.0408427807338358 no 250 0.0520594852965186 327 251141
SGTC_384 k007-0144 5.16 µM 1.6201273743031 0.0413221044355404 no 251 0.0526024590917145 424 6824886
SGTC_1803 st050068 52.4 µM 1.61922981789006 0.0414073120970517 no 252 0.0526989123111493 596 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_375 3970-0961 9.27 µM 1.61361947032086 0.0419431505986376 no 253 0.0533049954799333 376 2898222
SGTC_2229 7354935 190 µM 1.60718747726899 0.0425643561565917 no 254 0.0540066241259999 278 318112
SGTC_3311 9131146 2.8755 µM 1.60463440856938 0.0428129865269979 no 255 0.054287142224054 420 4900406 YPR165W RHO1
SGTC_2366 9070441 60.58 µM 1.60462689738221 0.0428137197313559 no 256 0.0542879692123242 384 6837235
SGTC_2036 5160441 105 µM 1.60114421256317 0.0431547767445563 no 257 0.0546724908198252 447 134534 YIL048W NEO1
SGTC_2097 5376186 200 µM 1.59910503441269 0.0433554885706485 no 258 0.0548986331250056 392 742755
SGTC_3162 9099653 49.47 µM 1.59452754804997 0.0438087857919342 no 259 0.0554089628228713 300 25237511
SGTC_522 1273-0010 11.6 µM 1.59402645233455 0.0438586393976871 no 260 0.0554650551503362 355 5705015
SGTC_1228 0124-0032 52.5 µM 1.58808720720369 0.0444530224831768 no 261 0.0561333103405431 389 X1228
SGTC_1936 st074407 74.3 µM 1.58699339614828 0.0445631925381281 no 262 0.0562570701536402 429 809813
SGTC_1037 k284-1091 78.7 µM 1.58465614236304 0.0447993408757651 no 263 0.0565222408180396 310 3334711
SGTC_2374 9071832 200 µM 1.58433169218233 0.0448322017411698 no 264 0.056559128695927 327 17381698
SGTC_1309 pyrazolanthrone 13.4 µM 1.57973790675404 0.0452995539941567 no 265 0.0570834503869207 389 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_518 1021-0119 62.6 µM 1.57570643762784 0.0457129201866194 no 266 0.0575467365773117 398 1097762
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.57421615215582 0.0458664918638927 no 267 0.0577187432096447 436 676296 Flavone; oxidizing agent.
SGTC_3165 9101544 49.47 µM 1.57221361694449 0.0460735026346179 no 268 0.0579505092553644 395 5002184
SGTC_252 miconazole 1.30953 nM 1.57050489413871 0.0462507335514231 no 269 0.0581488483497472 377 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1047 2043-3044 82 µM 1.56455301686137 0.0468723481963622 no 270 0.0588438763007305 408 669592
SGTC_1468 k284-1086 134 µM 1.56408581950764 0.0469214246240264 no 271 0.0588987078434964 471 15996457
SGTC_670 4204-0025 119 µM 1.56368473126854 0.0469635895324933 no 272 0.0589458126172723 417 719039
SGTC_399 oxolinic acid 75 µM 1.56087175641478 0.0472601615537582 no 273 0.0592770062360543 360 4628 A DNA gyrase inhibitor.
SGTC_2897 9048598 12.99 µM 1.55512585689876 0.0478706158320079 no 274 0.0599580489600312 361 6467404
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.55491962207847 0.0478926433818053 no 275 0.0599826067480062 386 803109
SGTC_2698 st077697 67.5 µM 1.55030258014403 0.0483879084546942 no 276 0.0605344541757961 374 3154499
SGTC_868 0527-0199 213 µM 1.55016810937699 0.0484023941464411 no 277 0.0605505859920329 401 2849450
SGTC_882 0843-0131 351 µM 1.54896516061221 0.0485321346114645 no 278 0.0606950476744301 408 5425421
SGTC_1757 st041620 31.8375 µM 1.54447967272926 0.0490183567873844 no 279 0.0612360859719173 400 5289815
SGTC_2471 5466956 24.79 µM 1.54278729157277 0.0492028171605609 no 280 0.061441196963053 347 724419
SGTC_128 0906-2981 13.371 µM 1.53900437553767 0.0496171389484034 no 281 0.0619016140228314 351 6740226
SGTC_313 3474-0040 5.03 µM 1.53614881097446 0.0499317333022564 no 282 0.0622509436225002 477 1043375 YIL048W NEO1
SGTC_1602 st001878 87.6 µM 1.53088216285804 0.0505161250241018 no 283 0.0628992591887698 380 595405 YLR310C CDC25
SGTC_3244 9134489 49.47 µM 1.53008485930107 0.0506050674790497 no 284 0.0629978627219333 390 16584271
SGTC_484 loperamide 105 µM 1.52857834894921 0.0507734653176858 no 285 0.0631845033972019 269 3955 An opioid-receptor agonist.
SGTC_1240 0356-0016 42.1 µM 1.5163762510844 0.0521539138291761 no 286 0.0647121203461734 412 4305613
SGTC_1708 st033234 31.827 µM 1.51571646924447 0.0522293976174752 no 287 0.0647955306994836 441 674664
SGTC_796 1234-0020 70.7 µM 1.49500218490289 0.0546436878337423 no 288 0.0674569359614532 440 46495034
SGTC_618 k072-0232 33.2 µM 1.49311403106665 0.0548680736650855 no 289 0.0677036701652593 394 5872756 YGL099W LSG1
SGTC_1885 st057546 99.9 µM 1.49009521791695 0.0552283378688825 no 290 0.0680996007046694 450 702008
SGTC_2411 st077133 39.94 µM 1.48862050165917 0.0554050080395979 no 291 0.0682936649066948 497 1403142 YNL221C POP1
SGTC_1261 0712-0010 12.7 µM 1.48281367964938 0.0561050035469168 no 292 0.069061960264953 474 2840123
SGTC_2781 5567276 71.43 µM 1.4768159162348 0.0568353195129791 no 293 0.0698624944583806 441 2853274
SGTC_1492 4158-0558 28.5 µM 1.47155047873475 0.0574826170305199 no 294 0.0705711533432418 407 3967268
SGTC_1875 nocodazole 6 µM 1.47095728344831 0.0575559024910855 no 295 0.0706513347102883 428 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_941 3237-0776 460 µM 1.46828412740813 0.057887065875071 no 296 0.0710135303090811 410 760008
SGTC_1148 3909-7663 27.7 µM 1.46818033586653 0.0578999542129078 no 297 0.0710276221081838 444 4084526
SGTC_547 1120-0019 610 nM 1.46777097284131 0.0579508089513697 no 298 0.071083222351006 446 3676939
SGTC_3085 9117376 49.47 µM 1.46574136652199 0.0582034635213741 no 299 0.0713593800168368 433 16480349
SGTC_822 1487-0950 154 µM 1.46312011702389 0.0585310481286341 no 300 0.0717172570649866 429 1958375
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.46122572493039 0.0587686952689237 no 301 0.07197675275213 528 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1226 3909-7979 35.4 µM 1.46011108764057 0.0589088774319946 no 302 0.0721297729246568 496 6615510
SGTC_1511 0906-3109 28.5 µM 1.45978341726851 0.0589501367009797 no 303 0.0721748037211277 551 2882180
SGTC_803 4488-1585 147 µM 1.45778353792065 0.0592024471698061 no 304 0.0724501086096815 398 747204
SGTC_1711 st032263 62.8 µM 1.45583271425816 0.05944938385301 no 305 0.0727194349054762 428 3958979
SGTC_3141 9094609 49.47 µM 1.45509695250816 0.0595427265183399 no 306 0.072821211372482 438 25236309 YDL196W YDL196W
SGTC_2658 polymyxin b sulfate 77.05 µM 1.45390587867412 0.0596940759436248 no 307 0.0729862013796602 467 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_515 4092-1064 102 µM 1.44924975703903 0.0602886221198067 no 308 0.0736339233198595 511 717353
SGTC_469 w7 172 µM 1.44911482305239 0.0603059208698967 no 309 0.0736527595562777 357 45115570 A P450 inhibitor.
SGTC_233 rapamycin 362 pM 1.44863922908417 0.0603669237465764 no 310 0.0737191799166167 434 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_951 1171-0579 82.7 µM 1.44398643536942 0.0609662724534874 no 311 0.0743713955050326 548 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2273 7815444 169.05 µM 1.44392872124562 0.0609737359905266 no 312 0.0743795132844535 429 2824616
SGTC_703 3875-0075 71.8 µM 1.43549775334396 0.0620717148611325 no 313 0.0755726540427135 452 2850814
SGTC_3078 9116413 49.47 µM 1.42949402196998 0.0628629504608713 no 314 0.076431145958243 424 17177322
SGTC_447 ml7 120 µM 1.42904687011626 0.0629221938966452 no 315 0.0764953812468156 462 4216 Selective myosin light chain kinase inhibitor.
SGTC_2028 5153890 36.43 µM 1.42124630555855 0.0639627083021035 no 316 0.077622583626461 455 2830968 YPR165W RHO1
SGTC_1277 0873-0036 22 µM 1.41970723738302 0.0641695755916543 no 317 0.0778464651209817 512 5965735
SGTC_2185 6113692 200 µM 1.41768454634366 0.0644422374185899 no 318 0.078141441925396 431 874150
SGTC_590 k048-0076 22.4 µM 1.41690845905075 0.0645470937977646 no 319 0.0782548465088067 462 6832814
SGTC_2570 licareol 100 µM 1.41303554773796 0.0650723411270865 no 320 0.0788226361433092 470 443158
SGTC_3186 9110464 49.47 µM 1.4106519233121 0.0653972554760542 no 321 0.079173636700696 466 17018021
SGTC_692 k241-0027 77.8 µM 1.41005186720276 0.0654792476900566 no 322 0.0792621841371747 458 3600480
SGTC_2769 toremifene 3.73 µM 1.40594374421736 0.0660427282982428 no 323 0.0798704151443598 436 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3098 9119039 49.47 µM 1.40567901272747 0.0660791679939505 no 324 0.0799097308754253 476 17161528
SGTC_2873 9040596 71.43 µM 1.40527442520687 0.0661348886494915 no 325 0.0799698451393639 483 6463863
SGTC_2775 cyproheptadine 69.59 µM 1.40502913354574 0.0661686884582178 no 326 0.0800063076148837 465 2913 A selective serotonin reuptake inhibitor.
SGTC_2129 girgensonine 121.053 µM 1.40295689567252 0.066454765391851 no 327 0.080314846489922 543 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_716 1683-5115 658 µM 1.39945914695826 0.0669398082074525 no 328 0.0808376704517876 538 723597
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.39818204683993 0.0671175882467347 no 329 0.0810292032865483 395 4620898
SGTC_1638 st008370 60.6 µM 1.39292073289848 0.0678538476028307 no 330 0.0818218810534254 512 24207134
SGTC_1645 Cervolide 78 µM 1.38392934778227 0.0691265049271627 no 331 0.0831900447251789 448 23173 A fragrance.
SGTC_728 3030-5151 22.5 µM 1.38225474454669 0.0693655502756967 no 332 0.0834467481196552 450 3125388
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.38079561945468 0.0695743553221475 no 333 0.0836709053924492 527 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_316 k060-0003 58.6 µM 1.38004801083147 0.0696815276325332 no 334 0.0837859314746125 466 6152314
SGTC_525 k781-2675 26.7 µM 1.37359305864476 0.0706121601474481 no 335 0.084784026537675 531 3651118 YDL195W SEC31
SGTC_1396 3511-0007 98.6 µM 1.36988866686049 0.0711505324520939 no 336 0.0853608289897327 433 X1396
SGTC_858 0438-0351 2.77 µM 1.36913770215499 0.0712600560387222 no 337 0.0854781175188726 522 2799119
SGTC_66 0109-0187 42.4 µM 1.36190126759557 0.0723220879055401 no 338 0.0866145230548709 481 759417
SGTC_2479 5617353 43.85 µM 1.36158361824095 0.0723689830763048 no 339 0.086664664020236 504 2731746
SGTC_961 1252-1571 372 µM 1.35923459240995 0.0727164976821136 no 340 0.0870361314457556 523 6813498
SGTC_1411 3909-8223 150 µM 1.35780699639809 0.0729283194955348 no 341 0.087262467160878 505 X1411
SGTC_2951 9072950 58.06 µM 1.35659314257944 0.0731087982353817 no 342 0.0874552609284092 530 16488155
SGTC_2327 6189656 200 µM 1.35367202035236 0.0735445185292121 no 343 0.0879205192367948 480 5349088
SGTC_2144 5628481 200 µM 1.35287298557178 0.0736640492950608 no 344 0.0880481055025837 449 2818399
SGTC_828 2074-0507 139 µM 1.35270764339746 0.0736888020189099 no 345 0.0880745238239492 536 X828
SGTC_3156 9099931 49.47 µM 1.35143214536139 0.073879965555784 no 346 0.0882785211775345 516 18111053
SGTC_2128 5255449 168.493 µM 1.34804572146281 0.074389339944712 no 347 0.0888218387579922 540 736008
SGTC_595 3909-8003 73.7 µM 1.34417864880202 0.0749742862907932 no 348 0.0894453121236093 513 699517
SGTC_1534 6-azauridine 81.6 µM 1.33771673665357 0.0759595568180528 no 349 0.0904943965095183 575 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3347 9188721 44.724 µM 1.33662437408895 0.0761270829522313 no 350 0.0906726393831693 477 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2994 9053520 71.4286 µM 1.33580726077936 0.076252580268241 no 351 0.0908061395741401 524 4647384
SGTC_2119 5528445 120.635 µM 1.33474738383861 0.0764155972103183 no 352 0.0909795197664192 516 791935
SGTC_1119 parthenolide 318.541 nM 1.33366754557165 0.076581956904748 no 353 0.0911564177639561 606 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2817 7995342 71.43 µM 1.33297121658695 0.0766893792267682 no 354 0.0912706248590945 442 18879975
SGTC_2218 6965428 192.983 µM 1.33152122063913 0.0769134370625598 no 355 0.0915087836362103 536 675684
SGTC_2311 7694451 200 µM 1.32504567433018 0.0779201354801348 no 356 0.0925780014006745 534 2163142
SGTC_499 genistein 192 µM 1.31832730987816 0.0789751183465476 no 357 0.0936970512981648 463 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1306 1185-0270 9.02 µM 1.31647658948386 0.0792676285963035 no 358 0.0940070654253038 597 1548076
SGTC_1874 staurosporine 7.6 µM 1.31536656076137 0.0794434640438351 no 359 0.094193369076988 549 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1721 st082152 9.2685 µM 1.31452418206754 0.0795770989562812 no 360 0.0943349328759773 490 5296051
SGTC_1610 st001799 48.1 µM 1.31332456079263 0.0797677003032677 no 361 0.0945368029040957 462 621897
SGTC_1191 1487-1166 10.6 µM 1.31179447958499 0.0800113074964085 no 362 0.0947947440339812 627 3955771
SGTC_2354 9060492 162 µM 1.309849950736 0.0803217108557094 no 363 0.0951233006367262 602 6471895
SGTC_232 clozapine 119 µM 1.30329697132659 0.0813744586885777 no 364 0.0962366973506462 533 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_69 0096-0274 206.684 µM 1.30108270344579 0.0817325273208268 no 365 0.0966150737715499 618 6741392
SGTC_1877 wortmannin 25 µM 1.30082587394761 0.0817741358969127 no 366 0.0966590316941391 606 312145 A covalent inhibitor of PI 3-kinase.
SGTC_972 1319-0219 195 µM 1.29835477342167 0.0821752915101275 no 367 0.0970827263416528 553 23903702
SGTC_3354 9151612 71.43 µM 1.29517374258407 0.0826938764207833 no 368 0.0976301503036057 589 27261949
SGTC_444 curcumin 90.4 µM 1.29199193469952 0.0832150479433904 no 369 0.0981799688466243 578 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_899 1083-0020 478 µM 1.2907449884124 0.0834199665933262 no 370 0.0983960595255369 572 767123
SGTC_1429 4049-0205 9.46 µM 1.28951090732205 0.0836231442213139 no 371 0.0986102634252388 582 22774478
SGTC_347 4534-1311 26.2 µM 1.28311453421907 0.0846821968588343 no 372 0.0997259762462168 560 2862016
SGTC_1552 6-methylflavone 10.6 µM 1.27972564676577 0.0852473584732998 no 373 0.10032082073709 493 689013
SGTC_2340 7987427 183.45 µM 1.27800602388925 0.0855352169867544 no 374 0.100623651139459 552 2239331
SGTC_17 0960-0276 49.807 µM 1.27691028921565 0.0857190182270344 no 375 0.10081696057145 601 6821114
SGTC_3231 9132313 49.47 µM 1.27549627464477 0.0859566452938636 no 376 0.101066820946462 569 4905967
SGTC_2830 7992007 71.43 µM 1.2719927358274 0.0865475430729122 no 377 0.101687850133054 544 1952075
SGTC_24 0417-1663 219 µM 1.2716266651127 0.0866094583989321 no 378 0.101752898951268 549 4329390
SGTC_409 arachidonic acid 100 µM 1.26994200726805 0.0868948196156364 no 379 0.10205264418338 579 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2167 5876490 200 µM 1.26903675334308 0.0870484488224886 no 380 0.102213977954041 567 686534
SGTC_2323 6148992 148.28 µM 1.26760206426755 0.0872923430232759 no 381 0.102470047197515 497 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3268 9137683 49.47 µM 1.2673176103238 0.0873407601550073 no 382 0.102520873074016 520 1953228
SGTC_2315 7733312 200 µM 1.263990803115 0.0879085077520556 no 383 0.103116663985432 517 726316
SGTC_836 0330-0104 1.35 µM 1.26105602121575 0.0884116339308023 no 384 0.103644332047674 577 46494820
SGTC_2866 9034245 58.44 µM 1.26028504288205 0.0885441622694442 no 385 0.103783276837372 506 6462273
SGTC_2464 5717415 7.67 µM 1.25679043666367 0.0891467282758229 no 386 0.104414764952175 588 5285744
SGTC_2961 9083290 32.55 µM 1.2565270724045 0.0891922628542553 no 387 0.104462468412825 534 17741490
SGTC_445 e6 berbamine 66 µM 1.24541759514063 0.0911288424516955 no 388 0.106489144455437 708 6610268 A calcium/calmodulin antagonist.
SGTC_1797 st048695 56.8 µM 1.24488559131922 0.0912223565111652 no 389 0.106586904006253 586 592262 YIL048W NEO1
SGTC_3246 9135460 32.98 µM 1.24481464879619 0.0912348319531599 no 390 0.106599945101843 496 41446951
SGTC_2441 5730946 39.09 µM 1.24182846215684 0.0917611092709713 no 391 0.107149929497011 597 1774275
SGTC_65 0798-0905 34.986 µM 1.24172847991244 0.0917787686942937 no 392 0.107168379180138 695 3602145
SGTC_1930 st074634 34.3 µM 1.23770287879798 0.0924918858000653 no 393 0.107913125664047 604 684253 YOR116C RPO31
SGTC_1756 st041558 35.5 µM 1.23345061821926 0.0932495980445144 no 394 0.108703844882365 653 3955792
SGTC_890 0929-0006 47.2 µM 1.2325544450176 0.0934098710772243 no 395 0.108871020951369 567 1378169
SGTC_293 4049-0273 38.5 µM 1.22578301028495 0.0946274673793935 no 396 0.110140171162991 554 1380311
SGTC_1657 st012939 43.4 µM 1.22550495892887 0.0946777136906444 no 397 0.110192511414932 552 24207257
SGTC_1664 st014217 9.02 µM 1.22355780262175 0.0950301329993326 no 398 0.110559543135949 647 3982782
SGTC_955 1216-0110 33 µM 1.21929587766167 0.0958048767732354 no 399 0.111365956348605 641 3619719
SGTC_2172 5754775 163.918 µM 1.21875374681575 0.0959037588658836 no 400 0.111468835818904 563 2263357
SGTC_3179 9107801 49.47 µM 1.2153724796588 0.0965221804312628 no 401 0.11211202969831 601 4818259
SGTC_816 0325-0417 81.3 µM 1.21440646189111 0.0966993985124414 no 402 0.11229627453353 581 68101
SGTC_2431 5490079 200 µM 1.21060865181576 0.0973984317897058 no 403 0.113022713410037 618 5722345
SGTC_1034 k072-0165 12.7 µM 1.21057823528943 0.0974040452461736 no 404 0.113028544939526 648 5835461
SGTC_1406 3909-7906 11.9 µM 1.20280830885457 0.0988457919924738 no 405 0.114525254368214 623 X1406
SGTC_1707 st032323 6.317 µM 1.20252126949404 0.0988993510012763 no 406 0.114580815257399 633 3132057 YMR211W DML1
SGTC_2505 galangin 7.89 µM 1.20158944299811 0.0990733679359581 no 407 0.114761316845729 531 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_642 0335-0876 158 µM 1.19995691889098 0.0993787785872365 no 408 0.115078036188558 629 6812350
SGTC_365 0121-0052 13.6 µM 1.19718247218184 0.0998993965175237 no 409 0.115617720074366 683 3101739
SGTC_561 1550-0330 72.9 µM 1.19593054244187 0.10013496910197 no 410 0.115861832575497 583 6812934
SGTC_1302 1159-0335 255 µM 1.19471136495382 0.100364768301064 no 411 0.116099910282981 600 649284
SGTC_2093 5331342 194.4 µM 1.19193110841901 0.100890249748077 no 412 0.116644129586742 636 33839
SGTC_1795 st049545 62.3 µM 1.19172085981426 0.10093006914493 no 413 0.116685357995102 603 5291882
SGTC_635 k038-0028 24.7 µM 1.19126224781629 0.101016966324947 no 414 0.116775324725642 637 4035102
SGTC_847 0342-0274 5.54 µM 1.18742781043043 0.10174564525528 no 415 0.117529457857232 641 18097
SGTC_2747 doxorubicin 7.63 µM 1.1830093903491 0.102590037955818 no 416 0.118402712931262 442 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_621 3584-0052 32.1 µM 1.1799410783241 0.103179404635893 no 417 0.119011825210812 664 2273927
SGTC_2585 alliin 100 µM 1.17332666718061 0.104458267177753 no 418 0.120332416136807 657 87310 A garlic compound which reacts with lipids.
SGTC_2954 9074818 52.69 µM 1.17266001501249 0.104587795275054 no 419 0.12046608602071 622 16648742
SGTC_842 0271-0008 11.1 µM 1.17014265994509 0.105077957362126 no 420 0.120971781703639 696 1221709
SGTC_422 cantharidin 155 µM 1.16863727919476 0.105371868014866 no 421 0.121274900921517 638 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1558 st069300 45.6 µM 1.16701651981474 0.105688969507185 no 422 0.121601849120192 575 24208000
SGTC_969 1313-0238 134 µM 1.16159187700605 0.106755318425596 no 423 0.122700641593318 686 5212874
SGTC_2020 4017018 200 µM 1.1612660483894 0.106819614457856 no 424 0.122766861053354 637 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_884 0851-0618 334 µM 1.15881056330198 0.107305056244889 no 425 0.123266705393604 681 9642473
SGTC_1101 ebselen 5.29 µM 1.15395917955291 0.10826883090102 no 426 0.124258452423314 709 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1591 genipin 88.4 µM 1.15342639750565 0.108375051705209 no 427 0.124367705868585 626 442424 A DNA cross-linking agent.
SGTC_2111 5486399 200 µM 1.15236026020939 0.108587832715145 no 428 0.124586531970826 722 689674
SGTC_3136 9095672 49.47 µM 1.15157685452152 0.108744377218234 no 429 0.124747498488448 578 17217380
SGTC_2970 9090938 41.86 µM 1.15130185171506 0.108799368281049 no 430 0.124804037817126 739 17217104
SGTC_3031 9088762 49.47 µM 1.15041841063747 0.108976161269608 no 431 0.124985790441192 670 205253
SGTC_1501 4491-0275 38.4 µM 1.14958203068236 0.109143726656418 no 432 0.125158031366291 657 5104718
SGTC_488 nitrendipine 139 µM 1.14656289713907 0.109750138315256 no 433 0.125781159119696 695 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2371 9071574 200 µM 1.1461339890004 0.109836482988378 no 434 0.125869857963981 595 45596039
SGTC_3037 9091026 49.47 µM 1.14158755506072 0.110754736698568 no 435 0.126812749687415 774 25236398 YIL048W NEO1
SGTC_1336 1486-0901 104 µM 1.14134942300891 0.110802983930507 no 436 0.126862271422764 660 5006114
SGTC_658 3253-0951 102 µM 1.14096817589879 0.110880258632664 no 437 0.126941583269885 768 1184878
SGTC_1873 rapamycin 2 nM 1.13893015965524 0.111293997528157 no 438 0.127366142553074 711 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2151 5563267 85.4165 µM 1.13849549738802 0.111382381381659 no 439 0.127456818973363 695 5310824
SGTC_1081 sertraline 6 µM 1.13827621392489 0.111426989354364 no 440 0.127502581498797 698 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_778 3456-2434 196 µM 1.13563376461236 0.111965538053103 no 441 0.128054935840695 763 5539063
SGTC_1068 loratadine 26.9 µM 1.13088101868035 0.112938858281357 no 442 0.129052586722656 643 3957 A H1 histamine antagonist.
SGTC_27 0485-0001 32.618 µM 1.13075051936358 0.112965668310131 no 443 0.129080055700967 588 2054479
SGTC_225 nsc-122657 1.016 µM 1.12964126303417 0.113193739469633 no 444 0.129313708255219 537 275685
SGTC_1529 apigenin 74 µM 1.12920112595335 0.113284325827895 no 445 0.129406499433852 706 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1472 k841-0093 193 µM 1.12712411266801 0.113712501993927 no 446 0.129845004904817 717 X1472
SGTC_1026 k007-1105 30.6 µM 1.1234515644137 0.114472418344066 no 447 0.130622880263487 750 7066794
SGTC_575 k072-0246 11.9 µM 1.12015127526148 0.115158385447152 no 448 0.131324651682322 712 6796779
SGTC_1229 0139-0193 12.2 µM 1.12010738339724 0.11516752804788 no 449 0.131334002329779 732 3090752
SGTC_2558 carylophyllene oxide 100 µM 1.11975474483143 0.115241000790565 no 450 0.131409144529406 726 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_974 1326-0144 138 µM 1.11952305233243 0.115289292384219 no 451 0.131458531018808 717 5411856
SGTC_2373 9071805 200 µM 1.11849089112574 0.115504600187837 no 452 0.131678697351523 697 10149009
SGTC_145 3737-0113 38.366 µM 1.11649645514595 0.115921446626508 no 453 0.13210484335799 782 6849351
SGTC_2278 7948257 134.34 µM 1.11567799455044 0.116092817445712 no 454 0.132279996621172 688 1247028
SGTC_2525 harmine 47.85 µM 1.11373794323411 0.116499747132825 no 455 0.132695813213952 649 5280953 A monoamine oxidase inhibitor
SGTC_646 4092-0839 27.3 µM 1.11088752459026 0.117099461739404 no 456 0.133308383012752 700 877796
SGTC_1354 1498-1681 81 µM 1.10973995014439 0.11734152249974 no 457 0.133555551193411 745 5754243
SGTC_1273 0849-0096 14.1 µM 1.10935112104959 0.117423619518092 no 458 0.133639369859014 707 5286025
SGTC_874 0599-0792 117 µM 1.10902077147052 0.11749340117542 no 459 0.133710610692669 771 765305
SGTC_846 0335-0850 148 µM 1.10785802261054 0.11773924888827 no 460 0.133961568472935 675 6819598
SGTC_1430 4049-0248 69.1 µM 1.10781937050002 0.1177474276082 no 461 0.133969916369157 774 22774488
SGTC_1271 0832-2808 169 µM 1.10539563553922 0.118261089052524 no 462 0.134494097052539 726 3663794
SGTC_109 0132-0036 33.701 µM 1.10316386585293 0.118735466629415 no 463 0.134978005030019 568 67274 A color developer.
SGTC_264 promethazine 12.5 mM 1.09752674611798 0.119939655420592 no 464 0.136205597732767 838 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_211 3455-0679 143.504 µM 1.09715532255528 0.120019299304159 no 465 0.136286749890656 739 748649
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.09524320380424 0.120429902392529 no 466 0.136705051315698 756 6708784 An antioxidant flavonoid
SGTC_2037 5169046 200 µM 1.09451383576371 0.120586785237611 no 467 0.136864841314548 688 5718022
SGTC_3047 9092122 49.47 µM 1.09439898926502 0.120611501161969 no 468 0.136890013521577 674 17173831
SGTC_892 0929-0076 29 µM 1.09209908587956 0.121107210605828 no 469 0.137394775594462 744 5751038
SGTC_3042 9091578 49.47 µM 1.09175310344293 0.121181905732229 no 470 0.137470818534577 674 25236497
SGTC_353 1988-1175 58.3 µM 1.09038265774697 0.121478093480558 no 471 0.137772308946104 656 2788357
SGTC_2724 maprotiline 69.64 µM 1.08891443964094 0.121795976563687 no 472 0.138095808998373 736 4011 A tricyclic antidepressant.
SGTC_2375 9072683 200 µM 1.0881453693478 0.121962720587168 no 473 0.138265468783637 798 16798029
SGTC_3319 9138450 16.7555 µM 1.08799476079329 0.121995393163635 no 474 0.138298710225632 683 2029690
SGTC_3065 9113888 49.47 µM 1.08683408539434 0.122247392906351 no 475 0.138555070497824 670 16648368
SGTC_2285 7945142 200 µM 1.08454940449184 0.122744497883808 no 476 0.139060637142014 681 2970608
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.0840446494474 0.12285451434147 no 477 0.139172501237172 737 688669
SGTC_1553 gossypol 38.6 µM 1.08403086823325 0.122857519065648 no 478 0.139175556296177 624 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1421 4029-0249 71.4 µM 1.08090081897522 0.123541300531139 no 479 0.139870617153632 812 2894095
SGTC_3308 9128332 17.569 µM 1.07918976372611 0.123916217419622 no 480 0.140251570964069 821 17332805 YDL196W YDL196W
SGTC_1980 st071811 45.7 µM 1.07904741792548 0.123947443279068 no 481 0.140283294926671 725 4974850
SGTC_1550 gossypolone 36.6 µM 1.07720159158882 0.124352853960048 no 482 0.140695107201181 742 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_887 0885-0007 9.62 µM 1.0762138736517 0.124570173265552 no 483 0.140915808207026 757 5719458
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.07600219675388 0.124616781285871 no 484 0.140963136972517 658 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_309 k408-0051 1.48 µM 1.0737675827545 0.125109552804787 no 485 0.14146343127035 784 3640463
SGTC_3134 9127454 49.47 µM 1.07119311520391 0.125678953067915 no 486 0.142041303318424 750 24262820
SGTC_971 1315-0384 26.7 µM 1.069831495028 0.125980835285198 no 487 0.142347581492887 709 6769120
SGTC_212 3807-4682 38.772 µM 1.06939645971421 0.126077392627862 no 488 0.142445530954378 880 3125501 YBL034C STU1
SGTC_3332 9141069 11.198 µM 1.06819705233051 0.126343871726356 no 489 0.142715817071065 663 17332883
SGTC_603 3794-0023 45.9 µM 1.06535939372416 0.12697589227405 no 490 0.143356662432034 739 3802260
SGTC_1916 st067606 49.2 µM 1.06503867195437 0.127047463542798 no 491 0.143429214970224 776 19590279
SGTC_2676 harmalol 100 µM 1.06465204093753 0.12713378022959 no 492 0.143516710214818 772 5459187 A monoamine oxidase inhibitor
SGTC_3052 9092717 49.47 µM 1.06449301678205 0.127169294752886 no 493 0.14355270810189 701 25237534
SGTC_2318 6029776 164 µM 1.06432791191292 0.127206174572014 no 494 0.143590088912637 732 818325
SGTC_9 0092-0002 10.449 µM 1.06420453735003 0.127233737862792 no 495 0.143618026000587 756 759368
SGTC_1149 3909-7961 23.3 µM 1.0638080730736 0.127322340652834 no 496 0.143707826694144 734 735261
SGTC_2308 7584454 197.62 µM 1.06368891281579 0.127348979260076 no 497 0.143734824357776 780 893577
SGTC_1345 1488-0192 31.4 µM 1.06212740207656 0.127698417603903 no 498 0.144088925880229 762 658348
SGTC_1855 st056195 39.6 µM 1.06088851964108 0.127976131222268 no 499 0.144370283601719 719 4028379
SGTC_1449 4112-4002 201 µM 1.05631729448803 0.129004467413171 no 500 0.145411638622175 698 2059539
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.05470035202004 0.12936958062459 no 501 0.145781195374461 554 4000243
SGTC_2745 rifampicin 24.3 µM 1.05287156733011 0.129783391060471 no 502 0.146199929418716 613 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2214 7179297 48.276 µM 1.04965418512533 0.130513630883437 no 503 0.14693856747257 763 769744
SGTC_3281 9140613 49.47 µM 1.04877666711812 0.130713290797951 no 504 0.147140459379708 691 16013766
SGTC_513 4245-1575 41.7 µM 1.04876763019301 0.130715348049253 no 505 0.147142539485867 856 719745
SGTC_339 3091-4833 71.4 µM 1.04705057567305 0.131106640829 no 506 0.1475381263318 750 3240077
SGTC_1255 0566-0045 221 µM 1.04555891137856 0.131447226497419 no 507 0.147882364035949 757 2788469
SGTC_1989 st071868 50.2 µM 1.04499894982906 0.131575237797154 no 508 0.148011727444774 782 16414057
SGTC_1154 4088-0362 150 µM 1.04369290325631 0.13187414388659 no 509 0.148313747141411 812 6618304
SGTC_628 1636-0253 16 µM 1.04118773008101 0.132448796168062 no 510 0.14889421459044 775 4456143
SGTC_1754 st042065 16.137 µM 1.04070610050421 0.132559472834942 no 511 0.149005985523132 855 1126236 YIL048W NEO1
SGTC_322 k048-0136 19.3 µM 1.04040968888541 0.132627618775954 no 512 0.149074801104547 716 6823282
SGTC_99 0109-0120 622.8 µM 1.03991670207361 0.132741011395731 no 513 0.149189301027923 722 759414
SGTC_33 0986-0033 35.816 µM 1.03779951419727 0.133228747897001 no 514 0.149681701528477 731 2848082
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.03770003475261 0.133251695266462 no 515 0.14970486439015 809 23847180
SGTC_1952 st077036 64.1 µM 1.03601380459381 0.133641079312489 no 516 0.15009785117334 757 2937007
SGTC_2816 7982706 58.44 µM 1.03529702564939 0.133806834545257 no 517 0.150265109232763 725 2981853
SGTC_3353 9151644 39.2805 µM 1.03261236095742 0.13442891919092 no 518 0.150892670592603 770 4909158
SGTC_301 4119-0100 24.5 µM 1.02243998939841 0.136804038629148 no 519 0.153286350905916 801 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2417 cerulenin 830 nM 1.02148123635542 0.137029365420092 no 520 0.153513247242909 764 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_809 3998-0021 90 µM 1.01957962950202 0.137477032297124 no 521 0.153963935020603 757 715485
SGTC_64 000l-0018 272.079 µM 1.01786538839131 0.137881445318191 no 522 0.154370966064282 852 6811119
SGTC_2725 haloperidol 53.21 µM 1.017536662523 0.137959088908749 no 523 0.1544491002716 778 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2002 4023503 131 µM 1.01701654872134 0.138081998392789 no 524 0.154572778499667 897 4736863 YCR052W RSC6
SGTC_406 estrone 100 µM 1.01466355829465 0.138638972776874 no 525 0.15513311544292 798 5870 A steroid.
SGTC_1780 st038448 24.544 µM 1.01250624997889 0.139150970554146 no 526 0.155648029942492 791 728868 YDL195W SEC31
SGTC_1084 voriconazole 435 nM 1.01147600318559 0.139395934303603 no 527 0.155894330385896 808 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_845 0330-0138 4.51 µM 1.01050015233421 0.139628234612663 no 528 0.156127863242218 787 9039800
SGTC_981 1488-1094 54.9 µM 1.0100339798079 0.139739299371717 no 529 0.156239505260651 731 3449522
SGTC_1495 4469-0029 237 µM 1.0065542612818 0.140570233227269 no 530 0.157074511873691 885 793680
SGTC_3229 9132204 49.47 µM 1.00616648818006 0.140663038160684 no 531 0.157167744827814 778 17682924
SGTC_3106 9121286 49.47 µM 1.00488612884454 0.140969759176706 no 532 0.157475842218768 745 15943471
SGTC_2179 6298986 200 µM 1.00337708723681 0.141331845005071 no 533 0.157839477487345 782 738374
SGTC_999 SEC7.066 22.7 µM 1.00325844306736 0.141360339695094 no 534 0.157868090655555 853 740511 YDR170C SEC7
SGTC_3247 9135149 49.47 µM 1.00163236091714 0.141751267151176 no 535 0.158260592755376 743 8934436 YOR116C RPO31
SGTC_3113 9123498 49.47 µM 1.00038267969043 0.142052200963137 no 536 0.158562674367055 829 8897275
SGTC_479 n-linoleoylglycine 10 µM 0.999705816419607 0.142215375785995 no 537 0.158726448216101 753 6433346 An anti-infammatory.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.999424493329619 0.142283233054031 no 538 0.158794549768764 726 2374 Ca(2+)-ATPase inhibitor.
SGTC_984 1492-0255 2.91 µM 0.998633826408997 0.142474065220025 no 539 0.158986053755764 761 1585198
SGTC_2019 4016004 108 µM 0.998288796565662 0.14255739445571 no 540 0.159069669337508 725 45595336
SGTC_1679 SEC14.276 6.7 µM 0.99350344828387 0.143716517506295 no 541 0.16023233543062 838 1005053 YMR079W SEC14
SGTC_2231 micatex 6.853 µM 0.991792173129303 0.144132567809727 no 542 0.160649458247355 808 20737 An antifungal of unknown mechanism.
SGTC_2732 terfenadine 20 µM 0.990722893603234 0.144392946083029 no 543 0.160910454507371 769 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1568 digitonin 820 nM 0.986264590165698 0.145481994036934 no 544 0.162001645558867 865 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2157 5649910 96.377 µM 0.982859061343592 0.146317588627766 no 545 0.162838404454886 809 2858091
SGTC_1124 fisetin 1.16336 µM 0.982730179355859 0.146349274805251 no 546 0.162870126630921 758 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1647 st011722 22.4 µM 0.982152872633901 0.146491264622924 no 547 0.163012270469989 772 2854783
SGTC_2975 9084847 53.72 µM 0.981939725091669 0.14654371208071 no 548 0.163064771805765 827 27211724
SGTC_178 4092-0806 87.505 µM 0.980628595955947 0.146866607996686 no 549 0.16338796366648 866 2169044
SGTC_340 k038-0059 454 µM 0.977816449253258 0.147560772687471 no 550 0.16408255697081 845 23733424
SGTC_1649 st011737 51.3 µM 0.977545952078059 0.147627659279404 no 551 0.164149469943296 808 1761035
SGTC_2163 5671233 125 µM 0.974916100571858 0.148279008407806 no 552 0.164800939460566 875 701023
SGTC_3323 9138564 53.9225 µM 0.973322653829007 0.148674599669483 no 553 0.16519648340522 903 43912313 YNL103W MET4
SGTC_1456 k015-0012 13 µM 0.972524900685982 0.148872915730436 no 554 0.165394741627155 909 2989616
SGTC_410 α-linolenic acid 100 µM 0.972353197438893 0.148915623108393 no 555 0.165437433573566 857 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1300 1094-0077 113 µM 0.971796599490637 0.149054120787597 no 556 0.16557587396204 781 5532636
SGTC_2130 NSC 7 2.4545 µM 0.970744883659624 0.149316052948932 no 557 0.1658376675266 866 21448
SGTC_2012 4023501 200 µM 0.969017855732134 0.149746839369563 no 558 0.166268140168776 756 3477460
SGTC_2922 7999257 32.47 µM 0.968561883655881 0.149860714350336 no 559 0.166381914408523 761 2988377
SGTC_1418 3966-3099 2.4 µM 0.966973690260644 0.150257802389266 no 560 0.166778593109351 844 740335
SGTC_1291 0993-0025 5.79 µM 0.966935212748143 0.150267431421012 no 561 0.166788211096348 856 4353356
SGTC_106 0092-0003 11.579 µM 0.96606848937344 0.150484438676964 no 562 0.167004955417696 785 1072148
SGTC_3074 9116018 49.47 µM 0.965698317008201 0.150577184767559 no 563 0.167097580951002 800 17027303
SGTC_2557 derrustone 83.84 µM 0.963406198851183 0.15115231887151 no 564 0.167671858348708 866 629853 An antioxidant.
SGTC_323 4013-0906 34.3 µM 0.958771371725103 0.152319741262537 no 565 0.168836967148121 871 2910086
SGTC_2681 menadione 3.18 µM 0.958669648941729 0.152345430187248 no 566 0.168862596551492 840 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_745 0469-0705 296 µM 0.95810642122403 0.15248771894196 no 567 0.169004548934597 940 3486736
SGTC_3001 9076041 71.4286 µM 0.957936834560209 0.152530579051186 no 568 0.169047305503156 830 16004211
SGTC_1447 4239-0816 81.9 µM 0.957516212179315 0.152636918612679 no 569 0.169153383738704 781 1341554
SGTC_433 pimozide 108 µM 0.957130311135807 0.152734523356436 no 570 0.169250743064641 714 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2718 lomofungin 53.02 µM 0.954797768914682 0.153325367149575 no 571 0.169839987947813 816 5351222 A RNA synthesis inhibitor.
SGTC_2701 st077767 14.721 µM 0.951582916131446 0.154142182928285 no 572 0.170654274519659 866 5721188
SGTC_157 1348-1695 65.819 µM 0.950193555625746 0.154496074735762 no 573 0.171006956269916 858 5380510
SGTC_1082 camptothecin 424.86 nM 0.949444368521406 0.154687127097362 no 574 0.171197326773461 752 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2855 9016525 58.44 µM 0.94894932613695 0.154813454904994 no 575 0.171323192732351 858 43811474
SGTC_623 k072-0108 16.9 µM 0.948906364426128 0.154824421338421 no 576 0.171334118660699 839 5382803
SGTC_2504 purpurogallin 52.29 µM 0.948392510776227 0.15495562772054 no 577 0.171464835321361 815 5281571 An antioxidant.
SGTC_1327 1436-0082 2.18 µM 0.948216275218285 0.155000644268737 no 578 0.171509681678113 858 15992205
SGTC_1736 st036774 51 µM 0.947622268990382 0.155152437242127 no 579 0.171660892615158 888 1272247
SGTC_298 1391-0729 10 µM 0.944455830256309 0.155963247688776 no 580 0.172468381498979 848 3237558
SGTC_2261 9010538 184.68 µM 0.943951926401524 0.156092536375555 no 581 0.172597107544661 741 6457250
SGTC_2671 danthron 100 µM 0.943133011665711 0.156302799312767 no 582 0.172806436139003 850 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_925 2064-1272 59.6 µM 0.942174867151161 0.156549047347663 no 583 0.173051559562887 800 6815817
SGTC_1815 st051655 58.2 µM 0.941488471902543 0.156725611379797 no 584 0.173227297104938 862 5984156
SGTC_1198 1612-1005 86.7 µM 0.940257659018102 0.157042546105771 no 585 0.173542706199347 885 6998509
SGTC_2113 5491891 107.031 µM 0.936982817436206 0.157887870534195 no 586 0.174383698254292 871 789979
SGTC_367 0335-0881 7.1 µM 0.936194024010193 0.15809192496465 no 587 0.174586649746894 872 23828853
SGTC_1725 st036284 20.55 µM 0.931884293315205 0.159209872521838 no 588 0.175698162814976 945 707914
SGTC_950 1165-0508 94.1 µM 0.930967179274674 0.159448439175712 no 589 0.175935270958343 806 6148369
SGTC_3293 9120939 62.045 µM 0.924980855046291 0.161011393400112 no 590 0.177487933061421 855 934087
SGTC_2436 5633522 8.09 µM 0.923271759973712 0.161459445374222 no 591 0.177932800365675 915 5724242
SGTC_1412 3909-8563 178 µM 0.921496620676044 0.161925671235111 no 592 0.178395602370064 978 23767530
SGTC_2634 4'-methoxyflavone 100 µM 0.920507676426424 0.162185789405401 no 593 0.178653761697204 814 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_227 fluconazole 33.516 µM 0.918905584633749 0.162607758473197 no 594 0.179072479307656 903 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_411 enrofloxacin 100 µM 0.918257227760802 0.162778729640632 no 595 0.179242107143914 941 71188 A bacterial gyrase inhibitor.
SGTC_686 1319-0111 510 µM 0.917688351171892 0.162928838181028 no 596 0.179391023974033 927 4562600
SGTC_567 1080-0542 68.4 µM 0.917452325739217 0.162991144236235 no 597 0.179452832008787 841 5950415
SGTC_2654 protoveratrine a 100 µM 0.915352722638132 0.163546079657866 no 598 0.180003244648287 902 5702278 A heart drug and vasodilator.
SGTC_1663 st014140 55.4 µM 0.912099631598866 0.164408307823883 no 599 0.180858136133454 1041 4207120
SGTC_601 0986-0029 62.9 µM 0.911582683697141 0.164545595146665 no 600 0.180994220687789 913 24747981
SGTC_917 harmaline 728.087 nM 0.910810316541238 0.164750853273357 no 601 0.181197662892697 878 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1744 st037937 38.9 µM 0.910653402160552 0.164792573849298 no 602 0.181239011780231 874 1016152
SGTC_1655 st012546 55.1 µM 0.907335917453387 0.165676232103504 no 603 0.182114592983183 849 720985 YLR208W SEC13
SGTC_1045 1348-1485 165 µM 0.906204751043288 0.165978233200365 no 604 0.182413744394756 1009 6810614
SGTC_1692 fluoroquinolonic acid 71 µM 0.906112625090721 0.166002844830255 no 605 0.182438121792308 891 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2200 6600604 21.907 µM 0.903938689811753 0.166584300268893 no 606 0.183013956127953 909 2904777
SGTC_2227 7312221 64.1025 µM 0.902921137079981 0.166856912907199 no 607 0.183283875797739 934 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2825 7998094 58.44 µM 0.901442201344951 0.167253647511179 no 608 0.18367662591584 864 2987815
SGTC_2487 5918373 44.05 µM 0.899960510732428 0.167651730347627 no 609 0.184070633045109 977 2876279
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.898320197495579 0.168093141120161 no 610 0.184507433845918 867 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3158 9100007 49.47 µM 0.898068157912086 0.168161031576502 no 611 0.184574606835661 870 19297233
SGTC_135 0933-0004 26.348 µM 0.897766974652938 0.168242182716415 no 612 0.184654897423531 853 21230617 YGL099W LSG1
SGTC_1276 0871-0068 94.2 µM 0.897265508362998 0.168377354212169 no 613 0.184788628400789 900 3414906
SGTC_2580 diallyl disulphide 81.36 µM 0.896514061640353 0.168580039267753 no 614 0.184989136798752 864 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2394 5221648 200 µM 0.893315312707929 0.169444580428658 no 615 0.185844169988811 1010 788586
SGTC_2473 5854593 8.94 µM 0.891978979520302 0.169806598696696 no 616 0.186202099726208 883 2872951
SGTC_2682 pyrogallin 40.03 µM 0.890363145152811 0.17024499692714 no 617 0.186635462525873 998 822798 An ATP competetive kinase inhibitor.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.888161821772806 0.170843412209296 no 618 0.187226855978963 948 94937 An inhibitor of serotonin biosynthesis.
SGTC_2981 9013952 38.96 µM 0.886444358111224 0.171311226978956 no 619 0.187689062552528 872 2996344
SGTC_2421 5690543 90.72 µM 0.886347567653934 0.17133761579523 no 620 0.187715131920207 916 3397993
SGTC_1096 rimcazole 32.2 µM 0.88542967365131 0.171587998303931 no 621 0.187962467009376 865 18528119 A dopamine reuptake inhibitor.
SGTC_2785 7756463 72.73 µM 0.882101089126904 0.172497927169476 no 622 0.188861071654493 939 2201551
SGTC_509 pifithrin 175 µM 0.882081051175858 0.172503414208254 no 623 0.188866489223362 987 4817 A p53 inhibitor.
SGTC_526 4469-0568 170 µM 0.880872687154899 0.172834509077756 no 624 0.189193366040114 895 2901964
SGTC_366 0181-0206 4.31 µM 0.87992265335407 0.173095104985812 no 625 0.189450605909425 972 274874
SGTC_2056 5235370 200 µM 0.879659232012783 0.173167406209519 no 626 0.189521970386323 885 5511916
SGTC_2708 st078559 56 µM 0.879529658011188 0.173202977426271 no 627 0.189557079840066 842 17250902
SGTC_3146 9095609 49.47 µM 0.875545264044952 0.174299061472233 no 628 0.190638646432753 935 17173999
SGTC_441 propafenone 146 µM 0.874957409410571 0.174461149225766 no 629 0.190798540051152 938 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_862 0452-0056 10.2 µM 0.874400951798249 0.174614668132445 no 630 0.190949969620605 921 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3235 9132602 49.47 µM 0.874362122960623 0.174625383668762 no 631 0.19096053891602 948 4912240
SGTC_2556 citropten 84.59 µM 0.874271170090345 0.174650485430988 no 632 0.190985297893032 1005 2775 A potential DNA crosslinker.
SGTC_2749 bexarotene 57.39 µM 0.873695857186777 0.174809317087019 no 633 0.191141953834564 909 82146 An retinoic acid receptor inhibitor.
SGTC_1564 D-Arginine 115 µM 0.870874719482941 0.175589499718984 no 634 0.191911280828667 919 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3084 9116877 49.47 µM 0.868417911256355 0.17627072204638 no 635 0.192582796508535 890 27241325
SGTC_2939 9044578 71.43 µM 0.867002395765075 0.176663973702845 no 636 0.1929703485109 919 2653634
SGTC_1004 4084-0029 199 µM 0.866506800625457 0.176801788553301 no 637 0.19310614930194 1000 716894 YLR208W SEC13
SGTC_1965 Pectolinarigenin 58.4 µM 0.865719496821174 0.177020861293559 no 638 0.193322002744211 973 5320438 An anti-inflammatory.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.86494985549966 0.177235185032696 no 639 0.193533155957609 1054 688801
SGTC_2742 clothiapine 36.27 µM 0.864782651502819 0.177281768363175 no 640 0.19357904742725 903 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1236 0330-0013 258 µM 0.862936621840302 0.177796589318185 no 641 0.194086157039674 925 4617066
SGTC_341 1486-1430 230 µM 0.862762144381787 0.177845296343434 no 642 0.194134128319421 963 2054753 YPL210C SRP72
SGTC_2412 st077135 33.4 µM 0.861602232691525 0.178169310530562 no 643 0.194453220982799 940 13258915
SGTC_454 lyso-paf C-16 6.67 µM 0.858236013599264 0.179111748293133 no 644 0.195381076805307 990 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1171 0368-0077 21.4 µM 0.858122595617334 0.179143556353409 no 645 0.195412385804074 913 3239779
SGTC_1773 st048542 73.5835 µM 0.857940376097034 0.179194667237196 no 646 0.195462693827046 916 3237138
SGTC_2164 5685496 200 µM 0.857934018239542 0.179196450722775 no 647 0.19546444927628 977 759046
SGTC_1223 0764-0573 147 µM 0.85704580279054 0.179445719767006 no 648 0.195709785919435 1012 1609797
SGTC_2482 5981709 142.65 µM 0.855126727000644 0.179985033592636 no 649 0.196240497424712 947 877755
SGTC_124 0136-0217 7.121 µM 0.854620582081127 0.180127443879226 no 650 0.196380614736321 1105 3976905
SGTC_1818 st052136 56.3 µM 0.854229463506911 0.18023753848081 no 651 0.196488930551892 912 674169
SGTC_2455 5377712 9.75 µM 0.853335385054777 0.180489368073225 no 652 0.196736671285209 858 2243908
SGTC_75 0159-0059 199.013 µM 0.851535277387359 0.180997062498542 no 653 0.197236037732856 953 5377270
SGTC_1503 4585-0012 61.3 µM 0.851247696021825 0.181078253498036 no 654 0.197315886430522 966 2922052
SGTC_2158 5657123 3.6195 µM 0.85085376373005 0.18118950689954 no 655 0.197425295833731 985 2858827
SGTC_1661 st013063 9.66 µM 0.84925635843176 0.18164108088819 no 656 0.197869329567794 1044 721395
SGTC_49 0717-0965 32.132 µM 0.848201449223354 0.181939681236966 no 657 0.198162895149562 1065 5889349 YGL099W LSG1
SGTC_1910 st062352 60.4 µM 0.847609820461743 0.182107280689534 no 658 0.198327651682494 991 2245730
SGTC_1730 st033808 45.1 µM 0.847349156394792 0.182181153484598 no 659 0.198400267531424 1028 1045166
SGTC_3132 9126706 49.47 µM 0.847018998129962 0.182274747977446 no 660 0.198492266113528 917 850858
SGTC_588 3970-1144 52.9 µM 0.846671884209993 0.182373181518975 no 661 0.198589017135073 963 1888707
SGTC_253 dyclonine 31.25 µM 0.845310008881762 0.182759698791242 no 662 0.198968887120559 1035 3180 An oral anasthetic.
SGTC_1800 st050079 29.0735 µM 0.841630174569946 0.18380663713152 no 663 0.199997496870719 1032 3645560
SGTC_770 0389-1121 67.2 µM 0.841450643644322 0.18385781031725 no 664 0.200047762112351 1033 6753108
SGTC_508 roscovitine 141 µM 0.840596246208916 0.184101467871314 no 665 0.200287081188214 1009 160355 A CDKinase inhibitor.
SGTC_1915 st067105 30.6 µM 0.838005058866693 0.184841652626159 no 666 0.201013931148596 986 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1113 artemisinin 1.17947 µM 0.837051193312553 0.185114593886898 no 667 0.201281896452055 1022 2240 An anti-malaria and mitochondrial poison.
SGTC_771 0250-0039 27.3 µM 0.836418169720305 0.185295866824353 no 668 0.20145984717777 953 3005115
SGTC_752 1896-0090 130 µM 0.836276890872504 0.185336338542158 no 669 0.201499575266104 989 772567
SGTC_2057 5236571 38.335 µM 0.836039247112416 0.185404427999727 no 670 0.201566412081266 1009 54684039 YBR257W POP4
SGTC_2983 9022671 12.99 µM 0.835585408645989 0.185534504491826 no 671 0.201694090107437 962 6405161
SGTC_2000 st075254 36.4 µM 0.834451060838073 0.185859872150493 no 672 0.202013427075209 954 17234175
SGTC_1798 st045719 60.953 µM 0.831900514517844 0.186592742696458 no 673 0.20273255070928 960 3980186
SGTC_2910 7948405 25.97 µM 0.829238648013734 0.187359505189342 no 674 0.203484689831315 974 2971328
SGTC_3029 9088683 49.47 µM 0.828687495053999 0.187518510319614 no 675 0.203640631801235 1022 25236615
SGTC_489 paxilline 115 µM 0.828173931129664 0.187666746213074 no 676 0.203786002532861 983 105008 A toxic potassium channel blocker.
SGTC_3172 9105863 49.47 µM 0.826284376500375 0.188212773126065 no 677 0.204321397011143 989 2348785
SGTC_1605 st000082 49.1 µM 0.826220125511957 0.188231357029915 no 678 0.204339616870692 1011 1114022
SGTC_3181 9108277 49.47 µM 0.823315381361097 0.189072705183415 no 679 0.205164334470308 1002 17097298
SGTC_1932 st074806 40.9 µM 0.823054933489129 0.189148255906054 no 680 0.205238377565988 1127 17251235
SGTC_2729 fluphenazine 10.66 µM 0.822341796007696 0.189355217959986 no 681 0.205441197666788 1016 3372 An atypical antipsychotic.
SGTC_1035 k081-0041 55.2 µM 0.820767016468998 0.18981273359484 no 682 0.205889494764895 1039 731709
SGTC_2282 7944268 200 µM 0.818974774864405 0.190334254038819 no 683 0.206400402843434 1005 2970414
SGTC_255 tunicamycin 200.472 nM 0.818946567874054 0.190342468957528 no 684 0.206408449711923 1005 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1175 0741-0056 27.6 µM 0.818033915032863 0.190608384719611 no 685 0.206668910906851 1089 765927
SGTC_2011 4012611 177 µM 0.815132146177237 0.19145537482278 no 686 0.207498336336143 1035 2049887
SGTC_1460 k062-0059 9.15 µM 0.813232154816034 0.192011205893701 no 687 0.208042483508346 1027 1373085
SGTC_649 1123-0311 367 µM 0.810940991903585 0.192682783780695 no 688 0.208699779134299 1036 693629 YIL048W NEO1
SGTC_3194 9111903 49.47 µM 0.809820259544241 0.19301181118025 no 689 0.20902174344801 1008 17087251
SGTC_1565 sinapyl alcohol 95.1 µM 0.807971933836183 0.193555196198838 no 690 0.209553369565496 1032 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1562 morin hydrate 59.1 µM 0.80738915887873 0.193726718152557 no 691 0.209721155443939 1003 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_675 1309-0189 238 µM 0.805168789474828 0.194381064563064 no 692 0.210361142122888 1017 4246530
SGTC_1698 5-fluorocytosine 1.055 µM 0.803650392963215 0.194829312190188 no 693 0.210799455517842 1054 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2832 7992762 51.95 µM 0.80359645379948 0.194845247189151 no 694 0.210815035906365 918 2985177
SGTC_1321 1326-2144 215 µM 0.80264455883106 0.195126591549037 no 695 0.211090102954948 1039 3513030
SGTC_2841 9004761 38.96 µM 0.80222203926004 0.195251551531033 no 696 0.211212264906004 1003 2991039
SGTC_362 0310-0100 9.03 µM 0.80207643812479 0.195294624267485 no 697 0.211254371767095 1005 790235
SGTC_470 aa-861 153 µM 0.801410492905884 0.195491702373099 no 698 0.211447021287424 1061 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1962 st076595 64.5 µM 0.800104163514007 0.195878644796631 no 699 0.211825224550568 1052 279619
SGTC_1954 st077032 68.9 µM 0.799629424932242 0.196019380203925 no 700 0.211962766962164 993 698907
SGTC_691 1548-0686 185 µM 0.796438840489691 0.196966813720221 no 701 0.212888505153664 1047 46495133
SGTC_2152 5568786 200 µM 0.796001701806843 0.197096836177928 no 702 0.213015523127231 1031 5399883
SGTC_1876 myriocin 605 nM 0.794009878834407 0.197689940915964 no 703 0.213594840152807 1066 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_203 k066-0004 30.888 µM 0.792899604316312 0.198021014836102 no 704 0.21391815894578 1156 6795412
SGTC_3346 9158254 43.5805 µM 0.791459439671863 0.198450957545423 no 705 0.214337967993468 1016 17639500
SGTC_2079 5212404 121 µM 0.791157177635728 0.198541265460569 no 706 0.214426138397913 1069 758462
SGTC_2815 7968870 71.43 µM 0.788618223182939 0.199300816226295 no 707 0.215167588390677 1071 2977326 YHR190W ERG9
SGTC_22 0964-0034 14.468 µM 0.787125293026762 0.199748255359983 no 708 0.215604262203899 1091 138402
SGTC_376 3970-0862 59.1 µM 0.786648152819677 0.199891384157892 no 709 0.21574393136468 1079 3135186
SGTC_2073 5212005 126 µM 0.78642970676806 0.199956932477984 no 710 0.2158078927024 936 691789
SGTC_2533 agelasine 13.65 µM 0.786208594752983 0.200023293924623 no 711 0.215872645829296 1091 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2184 6075246 200 µM 0.78608809212963 0.200059465458888 no 712 0.215907940019992 1025 2267320
SGTC_1608 st001473 40.5 µM 0.785362242312166 0.200277428543183 no 713 0.216120605958265 1000 7292267
SGTC_2741 miltefosine 3.04 µM 0.784524441385029 0.200529186377588 no 714 0.216366223089336 962 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2286 7945697 125 µM 0.78423286631074 0.200616848780408 no 715 0.216451741702193 1069 1245733
SGTC_133 0724-0033 378.92 µM 0.781702976925158 0.201378428592165 no 716 0.217194575879677 1001 280309
SGTC_2539 epi(13)torulosol 80 µM 0.78149662562495 0.201440623453275 no 717 0.217255230292926 1056 6708597
SGTC_351 caspofungin 25 nM 0.781242791224931 0.201517145641506 no 718 0.217329855193629 1152 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1619 st003326 88.7 µM 0.780116044383498 0.201857030580871 no 719 0.217661286685669 1057 2849032
SGTC_463 ikarugamyin 104 µM 0.779658243568095 0.201995224908699 no 720 0.217796031627729 1090 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2985 9022375 71.43 µM 0.77858667659295 0.202318915460232 no 721 0.218111614987858 1125 4939335
SGTC_472 calcifediol 10 µM 0.776924234943105 0.202821706358362 no 722 0.218601735998391 1017 5283731 A vitamin D metabolite.
SGTC_2862 9027634 71.43 µM 0.774587172908699 0.20352979121456 no 723 0.219291819632248 1034 5012562
SGTC_1405 3909-7894 12 µM 0.772617382915724 0.204127743243409 no 724 0.219874426931489 1096 7104060
SGTC_1811 st050069 61.5 µM 0.772121886518301 0.204278321328043 no 725 0.220021120247161 1086 3877702
SGTC_2235 salicylic acid 500 µM 0.77209289782432 0.204287132848205 no 726 0.220029704182268 1100 338 A COX inhibitor and kinase inhibitor.
SGTC_2679 rapamycin 1 nM 0.771853460564376 0.204359921815864 no 727 0.220100612063771 1120 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_958 1222-0007 33 µM 0.771784427333492 0.204380910796899 no 728 0.220121058267351 1114 7312461
SGTC_1947 st076332 61.6 µM 0.76876139672783 0.205301296128771 no 729 0.221017484720062 1078 24208416
SGTC_208 k072-0098 12.366 µM 0.767911688532264 0.205560439055223 no 730 0.221269826370323 1134 5948901
SGTC_3166 9102297 49.47 µM 0.767611287439265 0.20565210144258 no 731 0.22135907724067 1063 25237072
SGTC_2587 piperic acid 92.2 µM 0.767364993490957 0.205727272033051 no 732 0.221432267927026 1026 5370536
SGTC_2369 9071472 200 µM 0.766810861438348 0.205896456512203 no 733 0.221596988828876 1088 17296037
SGTC_2379 9035213 200 µM 0.765424345048071 0.206320141358315 no 734 0.222009450395258 1116 646551
SGTC_2351 9026858 72.31 µM 0.764490848815964 0.206605685354444 no 735 0.222287394023174 1060 1409300
SGTC_3236 9132701 49.47 µM 0.763890279810877 0.206789515034044 no 736 0.222466315207685 1072 24282524
SGTC_2470 5664817 21.68 µM 0.763221096155155 0.2069944611598 no 737 0.222665774737942 1129 2859561
SGTC_2913 7966556 36.57 µM 0.763092670124271 0.207033807030291 no 738 0.222704065564645 1042 2976516
SGTC_2357 9067248 200 µM 0.763062744548739 0.207042975961588 no 739 0.222712988555221 1060 9150235
SGTC_2183 6420625 130.508 µM 0.76277202606328 0.207132062033976 no 740 0.222799683484126 1144 2897619
SGTC_2485 5633444 17.78 µM 0.762607475299091 0.207182496055443 no 741 0.222848762558392 1075 5724239
SGTC_2488 5268135 45.7 µM 0.762591051081351 0.207187530398183 no 742 0.22285366159995 1100 1270356 YLR208W SEC13
SGTC_1821 st053465 65.6 µM 0.761931731955992 0.207389684299677 no 743 0.223050375014088 1067 675086
SGTC_246 cycloheximide 667 µM 0.760434819847835 0.207849085348178 no 744 0.2234973582581 1006 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2655 perillic acid 100 µM 0.757555159803493 0.20873453877205 no 745 0.224358666245178 1090 5702197 An apoptosis inducer.
SGTC_1820 st053765 18.6 µM 0.757115894881687 0.208869801470575 no 746 0.2244902160614 1103 3690829
SGTC_1307 1187-1599 12.2 µM 0.756302853758741 0.209120297152838 no 747 0.224733818758212 1105 1538471
SGTC_956 1185-0240 191 µM 0.75502102231664 0.209515584892844 no 748 0.22511818432768 1090 1416193
SGTC_1567 st069303 68.4 µM 0.754034380824672 0.209820141899257 no 749 0.225414288748909 1118 5581319
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.752875331730894 0.210178250002301 no 750 0.22576241650707 1178 6710655
SGTC_304 1310-0298 97 µM 0.751842202164166 0.210497755509496 no 751 0.22607297972444 1082 1550234
SGTC_116 0155-0182 31.788 µM 0.748726151358759 0.211463149838226 no 752 0.227011139085 1115 771486
SGTC_2021 4019055 173 µM 0.748363212378362 0.211575761535434 no 753 0.227120552840297 1144 44827708 YER133W GLC7
SGTC_448 monastrol 171 µM 0.74797377483356 0.211696634171722 no 754 0.227237988067289 1118 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2085 5307070 144.047 µM 0.745806712229391 0.212369979346808 no 755 0.227892092324366 1087 2840351
SGTC_2953 9074162 66.49 µM 0.744778295102626 0.212689964361227 no 756 0.22820287911557 1058 16451992
SGTC_949 1165-0505 146 µM 0.743594229712696 0.213058726701177 no 757 0.228560997597247 1137 6244267
SGTC_459 nigericin 15.3 µM 0.743393609457509 0.21312124430002 no 758 0.228621706096279 1187 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_918 glabranin 770.725 nM 0.741578006610877 0.213687511728815 no 759 0.229171526483417 1122 124049 Also referred to as licorice root.
SGTC_1263 0774-1208 64.8 µM 0.740971763170431 0.213876787690397 no 760 0.229355280657645 1154 906585
SGTC_2401 5128683 200 µM 0.740337486764847 0.214074920309995 no 761 0.229547620083239 1105 708373
SGTC_181 1447-1644 8.07 µM 0.739658786434951 0.214287048149693 no 762 0.229753530772356 1107 534600
SGTC_1621 st003705 32.4 µM 0.736854571274514 0.215164801064446 no 763 0.23060539642899 1164 24207032
SGTC_2523 spermine 47.74 µM 0.733397158394728 0.216249880325585 no 764 0.231658115918667 1114 1103 A DNA binding polyamine.
SGTC_3275 9138069 49.47 µM 0.732312934223297 0.216590806174614 no 765 0.23198879327493 1127 17617007
SGTC_1464 k208-0027 110 µM 0.731663301941907 0.216795226862768 no 766 0.232187050367942 1127 X1464
SGTC_1254 0550-0035 264 µM 0.730986029144861 0.217008463960307 no 767 0.232393843248696 1160 15121435
SGTC_3329 9141233 27.5565 µM 0.730321691852498 0.21721774606866 no 768 0.232596785998221 1134 4909101 YNL103W MET4
SGTC_1871 st057448 67.3 µM 0.72527475555705 0.218811454002677 no 769 0.234141744770604 1214 691747
SGTC_1669 st015249 58.4 µM 0.724645012096832 0.21901078374772 no 770 0.234334918622956 1236 722793
SGTC_811 0416-0114 265 µM 0.724458285528113 0.21906990750065 no 771 0.234392213961442 1165 6612453
SGTC_2062 5245942 200 µM 0.723162072608745 0.219480583921133 no 772 0.234790158640729 1240 1376160
SGTC_1093 fluphenazine 7.97 µM 0.721844327847093 0.219898535215878 no 773 0.235195096262752 1220 6602611 An atypical antipsychotic.
SGTC_1204 4049-0315 18.3 µM 0.717546285657467 0.22126492251819 no 774 0.236518543720946 1130 588402
SGTC_2300 7976697 71.57 µM 0.717322329229668 0.221336253199761 no 775 0.236587616242331 1070 2236109
SGTC_1859 st055998 20 µM 0.717057511164406 0.221420615380852 no 776 0.236669305607049 1180 676301
SGTC_946 3434-1334 87.4 µM 0.716319064975242 0.221655956731303 no 777 0.236897178648674 1120 4047976
SGTC_1294 1000-1494 117 µM 0.714456919100422 0.222250053223769 no 778 0.237472343216367 1154 712797 YDL207W GLE1
SGTC_20 0481-0013 4.944 µM 0.71398323444571 0.222401321761365 no 779 0.237618773307079 1162 182045
SGTC_1843 st055809 45.5 µM 0.71215458371417 0.222985841759156 no 780 0.238184528482567 1144 16413835
SGTC_2543 pimpinellin 60.67 µM 0.711361361568382 0.22323966349819 no 781 0.238430167994823 1110 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2352 9027995 87.8 µM 0.710412484734575 0.223543508819573 no 782 0.238724191685443 1126 2997347
SGTC_1686 st019653 115.5 µM 0.710139221270055 0.223631055693594 no 783 0.238808903236873 1185 97252
SGTC_2929 9013348 24.6 µM 0.709819416040783 0.223733538157513 no 784 0.238908063593158 1155 2995952
SGTC_1174 0739-0097 51.1 µM 0.709687220502619 0.223775908378865 no 785 0.238949059357647 1168 728447
SGTC_455 paf C-16 10 µM 0.709480290635408 0.223842240986884 no 786 0.23901323905005 1166 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1303 1160-0052 261 µM 0.709368228483575 0.223878167844879 no 787 0.239047999273229 1193 3562476
SGTC_730 1436-0052 41.2 µM 0.708463247884002 0.22416842252528 no 788 0.239328813741059 1210 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_303 1348-1668 34.2 µM 0.70808783257761 0.224288892266945 no 789 0.239445357549483 1181 5380509
SGTC_2066 5222451 176 µM 0.707754334800227 0.224395941610313 no 790 0.239548914482086 1206 2281147
SGTC_1347 1493-0251 600 nM 0.70607233800682 0.22493628695763 no 791 0.240071576547792 1185 3986378
SGTC_2210 7115885 190.385 µM 0.704621487427711 0.225402967911538 no 792 0.240522911412949 1195 2927039
SGTC_3102 9121669 49.47 µM 0.702985836646806 0.225929748483003 no 793 0.241032288024853 1192 41905072
SGTC_1977 st070720 65.3 µM 0.702239391921909 0.226170380913179 no 794 0.241264941654786 1172 682188
SGTC_284 0988-0104 32.6 µM 0.700894090650089 0.226604433067253 no 795 0.241684556285071 1212 4666532
SGTC_1000 4048-0884 8.67 µM 0.700808265918092 0.226632139769742 no 796 0.241711339422692 1181 13040088
SGTC_280 3448-3607 3.04 µM 0.700307670512306 0.22679378452265 no 797 0.241867591241607 1177 626179
SGTC_3131 9127911 49.47 µM 0.699424169335002 0.227079230104781 no 798 0.242143493846212 1230 45595681
SGTC_1193 1488-0126 41.5 µM 0.699245690403353 0.227136918472465 no 799 0.242199250533713 1221 1384710
SGTC_889 0919-1524 82.7 µM 0.698570744383718 0.227355150743073 no 800 0.242410166085672 1172 3905452
SGTC_244 nsc-207895 1.295 µM 0.698554873591751 0.2273602837138 no 801 0.242415126785893 1086 42640
SGTC_2955 9076254 12.21 µM 0.698133026247325 0.227496742552564 no 802 0.242547002884165 1130 16459619
SGTC_1167 k781-0610 148 µM 0.695220570404221 0.228440118984503 no 803 0.243458541484014 1215 4525169
SGTC_3040 9091894 49.47 µM 0.693384778797699 0.229035879617098 no 804 0.244034055943396 1120 25236966
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.693110966287199 0.229124813316207 no 805 0.244119958085229 1229 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2541 muurolladie-3-one 83.07 µM 0.690672335293392 0.22991772916199 no 806 0.244885739218511 1220 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1523 st012844 44.7 µM 0.690131244311897 0.230093871763642 no 807 0.245055828176463 1233 4274103
SGTC_3199 9111318 49.47 µM 0.689063877042832 0.230441555574309 no 808 0.245391535407293 1157 8548020
SGTC_2895 9054447 58.44 µM 0.688919569546095 0.230488584770774 no 809 0.245436941808272 1233 2697450
SGTC_265 mycophenolic acid 32.932 µM 0.687862507073926 0.230833240439619 no 810 0.245769684475081 1293 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3250 9135583 49.47 µM 0.687702744256013 0.230885356199954 no 811 0.245819995755941 1209 7699353
SGTC_182 3448-4371 550.524 µM 0.687267330299386 0.231027424657843 no 812 0.245957141039435 1227 3491403
SGTC_453 enantio-paf c16 10 µM 0.687163201297922 0.231061407477736 no 813 0.245989945338799 1214 13871343 A lipid and platelet activating factor
SGTC_523 1934-0222 13.7 µM 0.687005106970064 0.231113007380893 no 814 0.246039755102121 1222 1361595
SGTC_832 4083-0019 164 µM 0.686400133762777 0.231310522029963 no 815 0.246230410078074 1297 1990758
SGTC_2567 aureobasidin a 60 nM 0.685307086727838 0.231667624057197 no 816 0.246575080400577 1261 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_79 0052-0007 94.094 µM 0.685240411731784 0.231689416932856 no 817 0.246596113375106 1252 2801472
SGTC_392 N-ethylmaleimide 8.33 µM 0.68327065307815 0.232333752214909 no 818 0.24721791733584 1180 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3299 9121982 43.1275 µM 0.682243110389136 0.232670270880541 no 819 0.24754261953615 1236 17594604 YPL160W CDC60
SGTC_2170 morpholine 200 µM 0.681847979519733 0.23279974772456 no 820 0.247667541021854 1222 121171 Reacts with secondary amines.
SGTC_2888 9058547 12.99 µM 0.680548964827425 0.233225692077645 no 821 0.248078464526442 1147 16476514
SGTC_1785 bathophenanthroline 24 µM 0.679846871570357 0.233456087024339 no 822 0.248300712352277 1161 72812 An iron chelator.
SGTC_3251 9135047 49.47 µM 0.678929401053345 0.233757349145283 no 823 0.248591297829108 1205 17682963
SGTC_807 1315-0151 48 µM 0.678849677872026 0.233783537351383 no 824 0.248616556673415 1254 4011080
SGTC_1471 k673-0312 37 µM 0.678148817046431 0.234013832551385 no 825 0.248838670541954 1226 24099884
SGTC_1650 st011916 45.8 µM 0.678040695778438 0.234049371201842 no 826 0.248872945282861 1214 242528
SGTC_2 0422-0095 29 µM 0.67775222816669 0.234144202968918 no 827 0.248964402608193 1121 6790840
SGTC_2804 7954240 19.48 µM 0.677672504326646 0.234170415391662 no 828 0.24898968183805 1215 828705
SGTC_914 3820-6779 408 µM 0.676912251917302 0.23442046059119 no 829 0.249230815035356 1205 2893481
SGTC_3255 9139072 49.47 µM 0.676125872277277 0.234679254338686 no 830 0.249480365737743 1241 17646060
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.675615120160244 0.234847424986953 no 831 0.249642519555277 1214 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1931 st074438 57.1 µM 0.674490759476595 0.235217867479618 no 832 0.249999679274407 1201 2787313
SGTC_2549 cedrol 20.94 µM 0.673522400295652 0.235537170680117 no 833 0.250307501394433 1190 6708665 A sedative which affects the nervous system.
SGTC_228 caffeine 993.056 µM 0.672364701390032 0.235919219713587 no 834 0.250675774403961 1227 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_248 streptozotocin 5.23457 mM 0.671796504668679 0.236106853635117 no 835 0.250856627122466 1264 5300 DNA alkylating agent.
SGTC_2094 5332512 191.667 µM 0.671148942967832 0.236320796220105 no 836 0.251062825298866 1276 755774
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.670297209023497 0.236602356043513 no 837 0.251334172974349 1259 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1212 0520-0165 585 µM 0.669936359041087 0.236721698764105 no 838 0.251449180264901 1371 5403258
SGTC_1683 st010134 710 nM 0.669636784207417 0.236820801305505 no 839 0.251544679542908 1253 3818134
SGTC_3145 9085516 49.47 µM 0.669126039441789 0.236989813697501 no 840 0.2517075403202 1244 25236195
SGTC_3301 9125354 19.7965 µM 0.668204907413453 0.237294796349611 no 841 0.252001401673531 1217 41905162
SGTC_2237 6667747 47.222 µM 0.667283885241355 0.237599958013714 no 842 0.252295408876725 1191 729940 YDL015C TSC13
SGTC_1343 1487-0095 224 µM 0.66687196436592 0.237736509147048 no 843 0.252426960094554 1239 4560101 YGL055W OLE1
SGTC_2364 9055074 200 µM 0.665717882303363 0.238119314729029 no 844 0.252795720648992 1225 6470630
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.664875873822866 0.238398819420655 no 845 0.253064944062501 1283 1377
SGTC_440 fluspirilene 35.1 µM 0.662097167747988 0.239322484266974 no 846 0.253954475422916 1322 3396 An atypical antipsychotic.
SGTC_3108 9121785 49.47 µM 0.661880205379673 0.239394686537221 no 847 0.254023999343591 1217 17140271
SGTC_790 1575-0012 79.1 µM 0.661723691931102 0.239446779574552 no 848 0.254074159072723 1269 378741 YLR208W SEC13
SGTC_2576 guaiol 23.12 µM 0.661667495878205 0.239465485056233 no 849 0.254092170158747 1252 227829
SGTC_113 0099-0221 2.5 µM 0.661167250264146 0.239632032537747 no 850 0.254252530625136 1297 89219
SGTC_35 0133-0054 64.071 µM 0.660960710603748 0.239700814515678 no 851 0.254318755167624 1198 99677
SGTC_2807 7945238 51.95 µM 0.659983502263822 0.240026391128723 no 852 0.254632208226539 1275 17148797
SGTC_1784 st039334 36.3 µM 0.659907756197395 0.240051637519416 no 853 0.254656513269658 1314 3496984
SGTC_896 0964-0007 44.5 µM 0.659456322282969 0.240202131816495 no 854 0.254801392464879 1237 6756758
SGTC_1693 xanthone 101.9 µM 0.659191020277998 0.240290599395232 no 855 0.254886556262405 1293 7020 An insecticide.
SGTC_2034 5197015 53.07 µM 0.658503898373046 0.240519809503792 no 856 0.255107196433646 1275 780676
SGTC_2591 skatole 100 µM 0.655899742562373 0.241389583380369 no 857 0.255944316933522 1265 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3309 9129340 25.759 µM 0.654174178089357 0.24196685242483 no 858 0.256499797815684 1286 17158987
SGTC_1884 5633444 25 µM 0.654075909889955 0.241999749515631 no 859 0.256531450474416 1275 5724239
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.653776119745698 0.242100124778485 no 860 0.256628026889289 1285 1273210
SGTC_3350 9150499 3.57 µM 0.652976080578118 0.242368103101657 no 861 0.256885849546475 1237 4910996 YPR165W RHO1
SGTC_1731 st035964 63 µM 0.652402135699981 0.242560448635998 no 862 0.257070893481512 1272 6739575
SGTC_2974 9094440 9.66 µM 0.64736446890391 0.24425225821506 no 863 0.258698043029272 1352 25236134
SGTC_2426 5582046 32.21 µM 0.646944871096964 0.244393458996065 no 864 0.258833811841486 1285 2251934
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.645401395683725 0.244913239266907 no 865 0.259333549593278 1301 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_263 alizarin 107.927 µM 0.645186907208627 0.244985517383178 no 866 0.259403034892103 1275 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_602 3130-1533 38.1 µM 0.644340360639689 0.245270897813092 no 867 0.25967737444714 1311 720941
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.642254119493752 0.245974955564011 no 868 0.260354099403399 1293 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1349 flufenamic acid 69 µM 0.641574471907254 0.246204554739732 no 869 0.260574756276076 1250 3371 A non-steroidal anti-inflammatory.
SGTC_1062 mesoridazine 14.2 µM 0.6386063795519 0.247208583802823 no 870 0.261539515049539 1286 4078 A neuroleptic.
SGTC_2307 7538926 6.34 µM 0.637662424751522 0.247528357646335 no 871 0.261846725178075 1300 96582
SGTC_1001 4048-4355 44.4 µM 0.637424870741534 0.247608866163345 no 872 0.261924066279089 1272 21824233
SGTC_622 1348-1566 26.3 µM 0.636214414847392 0.248019314246959 no 873 0.262318339507242 1322 7340407
SGTC_2808 7946468 45.46 µM 0.636210242805047 0.248020729553657 no 874 0.262319698962523 1302 2970879
SGTC_762 1165-0429 115 µM 0.635686477184158 0.248198443898541 no 875 0.262490396055147 1312 5967793
SGTC_2713 st079149 53.4 µM 0.633997922398049 0.248771834751276 no 876 0.263041088993126 1314 3103253
SGTC_3010 9080089 71.4286 µM 0.633620739429845 0.248900012929502 no 877 0.263164181323324 1320 17027233
SGTC_2215 7188065 200 µM 0.633208344125738 0.249040197541711 no 878 0.263298798744357 1314 940217
SGTC_132 0417-1715 25.805 µM 0.632940790467648 0.249131168920252 no 879 0.263386154584927 1327 6769098
SGTC_213 1246-0773 967 nM 0.631997858118962 0.249451917835142 no 880 0.26369413840859 1288 6251622
SGTC_1282 0886-0010 32.4 µM 0.631882451468217 0.249491189757926 no 881 0.263731845541234 1343 2836211 YNL267W PIK1
SGTC_2272 7805186 180 µM 0.631389154756437 0.249659091551441 no 882 0.263893052727561 1284 2956062 YPR165W RHO1
SGTC_866 0495-0101 262 µM 0.631067014511576 0.24976876976064 no 883 0.263998353842842 1250 635694
SGTC_2139 5578692 56.4705 µM 0.630654959476822 0.249909098295902 no 884 0.264133077485655 1260 650991 YMR113W FOL3
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.630389046375212 0.249999679274407 no 885 0.264220037815569 1264 756377
SGTC_2211 7117706 200 µM 0.62971304430469 0.250230031900078 no 886 0.264441173271028 1251 822771
SGTC_1796 st049173 110.4 µM 0.628451472733262 0.250660222441036 no 887 0.264854113428121 1256 94134
SGTC_3341 9147222 25.867 µM 0.628148436705115 0.250763614754429 no 888 0.264953352593746 1284 1939759
SGTC_1435 4092-0789 56.7 µM 0.628098433778224 0.250780677332687 no 889 0.264969729521227 1345 2248285
SGTC_249 wiskostatin 11.211 µM 0.628017287873787 0.250808368186865 no 890 0.264996307471954 1308 2775510 A n-wasp and actin depolymerizer.
SGTC_3161 9100388 49.47 µM 0.627783986436921 0.250887990785043 no 891 0.265072728905317 1334 25236368
SGTC_1414 3917-0015 5.4 µM 0.62674593033565 0.251242427318256 no 892 0.265412895637195 1283 6618702
SGTC_491 tetrandrine 80.3 µM 0.6251319880727 0.251794021319807 no 893 0.265942217501516 1344 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_769 0302-0231 76 µM 0.623813592228571 0.252245081003083 no 894 0.266375006062419 1312 571869 YER009W NTF2
SGTC_3185 9108267 49.47 µM 0.623411763553166 0.252382642378589 no 895 0.26650698480834 1264 4910486
SGTC_2433 5607874 27.82 µM 0.623135677301588 0.25247718020974 no 896 0.266597683208865 1295 2252428
SGTC_912 3474-0017 2.18 µM 0.622698308580056 0.25262698279222 no 897 0.266741397216631 1380 3360550
SGTC_945 3381-0768 11.3 µM 0.618964114942049 0.253907880348304 no 898 0.267969999680059 1318 1126236 YIL048W NEO1
SGTC_3095 9117207 49.47 µM 0.618294645282836 0.254137880623715 no 899 0.268190565498313 1280 17015229
SGTC_3075 9116269 49.47 µM 0.617327626399577 0.254470298517193 no 900 0.268509324126795 1343 17015205 YNL244C SUI1
SGTC_1790 st045711 43.5 µM 0.616934330017958 0.254605561389648 no 901 0.268639020952905 1357 585119
SGTC_2943 9068529 45.32 µM 0.616121492375558 0.254885232598127 no 902 0.268907169070343 1318 3270634
SGTC_1221 2958-7315 257 µM 0.615848649472401 0.254979145067853 no 903 0.268997207704291 1321 4562705
SGTC_2700 st077718 96.8 µM 0.615384636514636 0.255138899797022 no 904 0.269150367533839 1315 904970
SGTC_959 1222-0044 107 µM 0.615208285380883 0.255199629343075 no 905 0.269208588392352 1301 6083612
SGTC_3209 9113616 49.47 µM 0.61504004062219 0.25525757436407 no 906 0.269264138886647 1339 16649353
SGTC_217 ketoconazole 989 nM 0.611431369674615 0.256502087465885 no 907 0.270457020208237 1266 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1982 st072467 71.9 µM 0.611431209094271 0.256502142915064 no 908 0.270457073348334 1313 3163533
SGTC_206 4546-0025 72.014 µM 0.610476425611792 0.25683194468794 no 909 0.270773127559874 1329 6620745 YIL048W NEO1
SGTC_2317 5986382 200 µM 0.610040486955699 0.256982600183943 no 910 0.270917494074516 1388 877883
SGTC_357 1325-0123 420 µM 0.609966528618841 0.257008163913943 no 911 0.270941990108987 1323 1098503
SGTC_3249 9135183 49.47 µM 0.607950434651873 0.257705536828549 no 912 0.271610173974052 1359 4902779
SGTC_1616 st002734 56.1 µM 0.60707737921031 0.258007833832108 no 913 0.271899780714123 1320 4026101
SGTC_102 gallobenzophenone 83.616 µM 0.605591904244143 0.258522604576876 no 914 0.272392889791773 1409 70837
SGTC_991 3996-0057 64.7 µM 0.60481474608891 0.258792129740438 no 915 0.272651047273784 1341 715343
SGTC_289 k017-0060 526 µM 0.60457997799707 0.258873577933128 no 916 0.272729056741411 1320 5512909
SGTC_1600 coumarin 106 71.1 µM 0.601834861529834 0.259826925580608 no 917 0.273642033526619 1384 100336 A hepatotoxic, DNA x-linker.
SGTC_1779 st039427 55 µM 0.601119464817715 0.260075671914053 no 918 0.273880209859839 1466 1124498
SGTC_1362 1611-0397 101 µM 0.598167304326695 0.261103447220961 no 919 0.274864152586772 1341 27816
SGTC_1448 4255-0083 152 µM 0.597901847278292 0.261195966548861 no 920 0.274952713609727 1465 5399660
SGTC_2393 9031399 185.94 µM 0.596042646718912 0.261844422646455 no 921 0.275573368571112 1400 1526623 YDL150W RPC53
SGTC_3183 9108214 49.47 µM 0.595694315297613 0.261966006229127 no 922 0.275689728267785 1268 4974831
SGTC_1317 1273-0028 910 nM 0.594869936050128 0.262253867524421 no 923 0.275965207355697 1338 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1020 4335-0961 93.3 µM 0.594454701851792 0.262398922633334 no 924 0.276104015471804 1289 669075
SGTC_763 3453-1109 128 µM 0.5937480703331 0.262645866922383 no 925 0.27634031319878 1352 1560353
SGTC_732 3970-1727 52.7 µM 0.593029639290691 0.262897056605671 no 926 0.276580658348217 1392 1275699
SGTC_837 0091-0265 12.5 µM 0.592767430980394 0.262988764775933 no 927 0.276668403480985 1329 759367
SGTC_854 0422-0053 192 µM 0.592299682029522 0.263152402017459 no 928 0.276824964397213 1337 3596728
SGTC_2044 5102272 200 µM 0.590698677109192 0.263712890875791 no 929 0.277361167248797 1346 592666
SGTC_417 st075190 100 µM 0.590594554714301 0.263749363709081 no 930 0.277396057129472 1416 222757
SGTC_619 1652-1634 108 µM 0.590299133486457 0.263852860244841 no 931 0.277495060109943 1332 5400454
SGTC_669 0108-0021 26.2 µM 0.589909499907914 0.263989394365713 no 932 0.277625662388778 1547 17201
SGTC_202 3594-0513 34.79 µM 0.588425748593384 0.26450965505564 no 933 0.278123279532699 1339 708429
SGTC_1892 st058411 7.36 µM 0.586002301515672 0.26536053000894 no 934 0.278936984106574 1412 3934738
SGTC_1958 st076513 41.9 µM 0.585596977638252 0.265502975152307 no 935 0.279073189950302 1307 732122 YGL099W LSG1
SGTC_1830 st055982 50.3 µM 0.584613919439423 0.265848617628192 no 936 0.279403673066078 1344 455313 An antimicrobial agent.
SGTC_361 000s-0510 1.45 µM 0.582420051659743 0.266620801236316 no 937 0.280141889219726 1371 660
SGTC_819 1013-0258 27.7 µM 0.582011000970387 0.266764901623777 no 938 0.280279635450638 1353 5753198
SGTC_215 1287-0124 461.5 µM 0.581803496050407 0.266838016507435 no 939 0.280349524466267 1419 5560863
SGTC_171 k064-0041 9.68 µM 0.579967201732348 0.267485480416884 no 940 0.280968367921794 1320 53325
SGTC_2794 7785382 27.27 µM 0.579886783402682 0.267513853427073 no 941 0.280995484517805 1355 2205081
SGTC_1905 st060207 84.5 µM 0.578663732212085 0.267945554499174 no 942 0.281408046108177 1363 1948547
SGTC_1926 methyl fluorone black 53.6 µM 0.577817889002743 0.268244317328228 no 943 0.281693538174531 1281 72721 Reacts with homocysteine.
SGTC_2462 5162487 171.77 µM 0.577646882187996 0.268304739521746 no 944 0.281751273979589 1351 2259986
SGTC_1486 3970-0793 4.53 µM 0.576654325575419 0.268655576748088 no 945 0.282086496342314 1410 2844330
SGTC_2593 nobiletin 86.24 µM 0.57638476127218 0.268750898953217 no 946 0.282177571132276 1320 72344 An anti-infammatory.
SGTC_3153 9100258 49.47 µM 0.576373209879319 0.268754984088196 no 947 0.282181474193299 1325 25236848
SGTC_1717 st033143 58.0435 µM 0.576368495772129 0.268756651235001 no 948 0.282183067034483 1448 674616
SGTC_614 0462-0418 107 µM 0.576123977526629 0.268843132380075 no 949 0.282265692797461 1279 5188303
SGTC_781 4335-2806 94.4 µM 0.5755458521676 0.269047659163358 no 950 0.282461094853586 1488 845254
SGTC_1469 k284-2957 126 µM 0.571891086667975 0.270342431478823 no 951 0.28369788147873 1415 23884841
SGTC_1009 4106-0057 9.87 µM 0.571382836596901 0.270522735416904 no 952 0.283870080454479 1381 2928005
SGTC_1330 1469-0054 61.8 µM 0.569963220178621 0.271026668608261 no 953 0.284351322108732 1423 7102664
SGTC_2038 4100038 30.985 µM 0.569492898233813 0.271193725955602 no 954 0.2845108444334 1398 3596803
SGTC_97 0535-0701 19.132 µM 0.567653483739927 0.271847574663105 no 955 0.285135141438447 1331 2832013 YGL099W LSG1
SGTC_162 k030-0015 37.8 µM 0.567390353224759 0.271941172615633 no 956 0.285224501251736 1453 1809920 YMR134W ERG29
SGTC_773 4358-1457 44.6 µM 0.566357353999501 0.272308774889852 no 957 0.285575439463389 1449 1186886
SGTC_1560 lithocholic acid 53.1 µM 0.565334459992093 0.272673024241038 no 958 0.285923147027311 1364 9903 A bile acid which acts as a detergent.
SGTC_419 nsc-638432 893 µM 0.564312477378745 0.273037190363152 no 959 0.286270745646166 1391 368090
SGTC_1107 amlodipine 47 µM 0.563570576647135 0.273301705021371 no 960 0.28652320793276 1305 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1413 3910-0535 34.4 µM 0.562896332281867 0.273542207757395 no 961 0.286752738932775 1448 2876951
SGTC_2893 9048488 25.97 µM 0.561934376071216 0.273885518437924 no 962 0.287080365634477 1318 6467338
SGTC_893 0958-0369 48.9 µM 0.56184020455376 0.273919138571698 no 963 0.287112448451014 1475 6819948
SGTC_1438 4092-1045 4 µM 0.560960537404105 0.27423328666937 no 964 0.287412219751836 1378 1351342
SGTC_1579 chlormadinone acetate 49.4 µM 0.56068627280437 0.27433126884117 no 965 0.287505713386139 1464 45114258 A steroidal progestin.
SGTC_1132 3456-3614 2.5 µM 0.557391522443871 0.275509681274238 no 966 0.288629978188794 1579 3125502
SGTC_1506 4226-2149 212 µM 0.554871458570177 0.276412693821087 no 967 0.289491292674042 1442 991114
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.554236616139407 0.276640405103024 no 968 0.289708461096438 1377 688662
SGTC_1522 st012842 45.6 µM 0.553028700055728 0.277073925573536 no 969 0.290121878925219 1345 3491067 YOR116C RPO31
SGTC_1210 3013-0140 750 nM 0.548200612543328 0.278810036781456 no 970 0.291777080781963 1519 905973
SGTC_60 0986-0278 202 µM 0.548122530822442 0.278838157296762 no 971 0.291803885472552 1229 3110598
SGTC_2941 9056145 11.23 µM 0.547778586200333 0.278962042664388 no 972 0.291921971950289 1331 2119517
SGTC_114 0364-0001 490.298 µM 0.544693895653227 0.280074312208511 no 973 0.29298203195699 1374 4003655
SGTC_1766 st045414 44.774 µM 0.543469652813607 0.280516341499563 no 974 0.293403239958106 1434 253960
SGTC_158 k038-0087 26.446 µM 0.542087871061608 0.281015657586568 no 975 0.293878986904895 1449 X158
SGTC_3339 9145883 14.936 µM 0.541009720885689 0.281405552404031 no 976 0.294250441239475 1419 2030670
SGTC_663 1486-0733 13.9 µM 0.54054470350068 0.281573798636563 no 977 0.294410720272997 1420 722445 YPR165W RHO1
SGTC_983 1491-0821 12.2 µM 0.540476770689708 0.281598381218338 no 978 0.294434138266523 1463 46495113
SGTC_2757 clomiphene 4.22 µM 0.538869335844126 0.282180359203799 no 979 0.294988508531618 1540 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1007 4101-0031 70 µM 0.537627400510079 0.28263040277348 no 980 0.295417154771626 1496 1146276
SGTC_209 4077-0173 175.592 µM 0.535633105706519 0.283353801889555 no 981 0.296106071992161 1395 15993494
SGTC_548 1436-0017 110 µM 0.53507291642204 0.283557161350875 no 982 0.296299718576765 1533 9677137
SGTC_2022 5136654 200 µM 0.533017707055855 0.284303840124708 no 983 0.297010661497696 1446 1713771
SGTC_824 1304-0008 100 µM 0.532475457742729 0.284501001469567 no 984 0.297198367680053 1437 768245
SGTC_401 neomycin 50 µM 0.532332854218441 0.28455286282219 no 985 0.297247740624737 1432 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_610 4215-0184 155 µM 0.531739191260607 0.284768811771824 no 986 0.29745332201985 1469 5605015
SGTC_2155 5570423 76 µM 0.531658249557883 0.284798260925819 no 987 0.297481356603491 1434 797402
SGTC_317 4495-0002 170 µM 0.531338356361935 0.284914662416974 no 988 0.297592165095952 1397 15991618
SGTC_1960 st011366 51.8 µM 0.531176611435387 0.284973526167976 no 989 0.297648199439241 1431 3972846
SGTC_1742 st038235 28.8875 µM 0.530976338894011 0.285046419290339 no 990 0.297717587824918 1457 564103 YBR002C RER2
SGTC_1570 verbenone 133 µM 0.528679273277229 0.285883116481795 no 991 0.298513978867853 1497 29025 A natural terpanoid with antifungal properties.
SGTC_2881 9058953 51.95 µM 0.527626450546233 0.286266992905931 no 992 0.298879315373466 1384 17122249
SGTC_11 0438-0307 1.3 µM 0.525901092608583 0.286896615382661 no 993 0.299478464873507 1521 4011476
SGTC_1250 0485-0349 40.2 µM 0.525036546581252 0.287212354529276 no 994 0.299778892610554 1448 6842794 YDL195W SEC31
SGTC_520 3584-0023 682 µM 0.523858915966423 0.28764269908473 no 995 0.300188335921445 1421 1340790
SGTC_3196 9111891 49.47 µM 0.523721510600914 0.287692931324516 no 996 0.300236126035624 1416 18891510
SGTC_2544 sphondin 68.51 µM 0.522430993490588 0.288164916858923 no 997 0.300685140594088 1497 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.522408918430826 0.288172993628105 no 998 0.300692823890038 1413 5355888
SGTC_1369 1866-0067 208 µM 0.522363237262077 0.288189707682202 no 999 0.300708723649965 1541 3531355
SGTC_380 3970-0968 6 µM 0.522227370716045 0.288239421915051 no 1000 0.300756015519947 1399 2891601
SGTC_175 3793-3120 23.7 µM 0.52164671197769 0.288451933355014 no 1001 0.300958166639409 1436 5322297
SGTC_1607 st000305 50.6 µM 0.520273552526985 0.288954780465466 no 1002 0.301436463320623 1494 5457690
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.520035218462182 0.289042099715186 no 1003 0.301519514288972 1410 6708760
SGTC_656 4090-1979 187 µM 0.519900096503816 0.289091610312198 no 1004 0.301566604071675 1531 22330961
SGTC_1403 3909-7815 62.9 µM 0.518809623884569 0.289491320807818 no 1005 0.301946753030226 1484 6615483
SGTC_3071 9117417 49.47 µM 0.518027518384641 0.289778159711117 no 1006 0.302219534823228 1470 45595590 YGL055W OLE1
SGTC_1590 st077108 57.8 µM 0.517352463128512 0.290025844871046 no 1007 0.302455068649258 1471 5489485
SGTC_1139 k015-0024 46.9 µM 0.515232653712448 0.29080427057551 no 1008 0.303195226734488 1457 2766652
SGTC_1252 0493-0875 34.8 µM 0.514752528817292 0.290980715194721 no 1009 0.303362980805436 1443 3960963
SGTC_1301 naphtanilide LB 4.81 µM 0.514689430163954 0.291003907500055 no 1010 0.303385030352292 1567 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2108 5365811 200 µM 0.514666853586794 0.291012205872206 no 1011 0.303392919811822 1531 780283
SGTC_2651 TUB2.036 5 µM 0.511311629541882 0.292246697896557 no 1012 0.304566431489944 1534 15992207 YFL037W TUB2
SGTC_2309 7664088 163.95 µM 0.511311587245868 0.292246713473929 no 1013 0.304566446295974 1495 704922
SGTC_1341 1486-1360 280 µM 0.511093728799847 0.292326954576782 no 1014 0.304642713491736 1442 3976547
SGTC_742 0kpi-0133 140 µM 0.509435006743943 0.292938226832422 no 1015 0.305223671952691 1546 2728852
SGTC_2476 5806916 10.51 µM 0.508550878241446 0.293264288031124 no 1016 0.305533533926267 1490 2870194
SGTC_139 0099-0334 718.624 µM 0.508378354005156 0.293327933528399 no 1017 0.30559401503475 1484 97690
SGTC_2440 5628896 157.78 µM 0.507766152972665 0.293553830767082 no 1018 0.305808674622562 1501 5522048
SGTC_2460 5552655 174.22 µM 0.506272024275344 0.294105490137467 no 1019 0.306332849688772 1431 5401989
SGTC_3254 9136651 49.47 µM 0.505979461366151 0.294213565729011 no 1020 0.306435534021146 1435 16454030
SGTC_1352 1496-0991 99 µM 0.505022824854061 0.294567084602065 no 1021 0.306771402360056 1476 3000039
SGTC_598 3937-0236 20.2 µM 0.504979794542628 0.294582990782304 no 1022 0.306786513815423 1515 1379313
SGTC_2238 6671620 73.2395 µM 0.503801372802623 0.295018749023109 no 1023 0.307200481455593 1409 729941
SGTC_3089 9117425 49.47 µM 0.50369456778541 0.295058258185572 no 1024 0.307238013135008 1412 9401657
SGTC_510 ag-490 170 µM 0.503685599599529 0.295061575795247 no 1025 0.307241164680702 1572 5328779
SGTC_1340 1486-1359 257 µM 0.503008425668257 0.295312133015915 no 1026 0.307479174159465 1499 4309068
SGTC_2257 7960413 200 µM 0.502887414915132 0.295356917816474 no 1027 0.307521714915057 1544 2974689 YIL048W NEO1
SGTC_921 1561-0023 372 µM 0.502095965091658 0.295649902054897 no 1028 0.307800009157808 1444 24050882
SGTC_564 3555-0129 330 µM 0.50197894541461 0.295693232522081 no 1029 0.307841165694452 1433 563260
SGTC_2490 carminic acid 95.39 µM 0.501975446573204 0.295694528130603 no 1030 0.307842396295615 1468 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1747 st037496 66.6 µM 0.501569391375121 0.295844906642245 no 1031 0.307985227391952 1465 723305
SGTC_689 0833-0039 98 µM 0.500949257439393 0.296074634851369 no 1032 0.308203417443639 1523 5374726
SGTC_2771 fluoxetine 41.05 µM 0.499950003116499 0.296444980099519 no 1033 0.308555141115122 1521 3386 A selective serotonin reuptake inhibitor.
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.49912295652883 0.296751661930843 no 1034 0.308846382995174 1493 616764
SGTC_1727 st034309 9.9045 µM 0.497421621426762 0.297382999939343 no 1035 0.309445880801402 1607 870305
SGTC_1801 st050089 28.441 µM 0.497280258837591 0.29743548491177 no 1036 0.30949571545669 1476 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1819 st053448 58.6 µM 0.497157647933193 0.297481011201499 no 1037 0.309538942404167 1512 2857616
SGTC_833 3852-0053 558 µM 0.496753540730041 0.297631081564378 no 1038 0.309681430609601 1561 3123681
SGTC_2283 7944793 200 µM 0.496011439225623 0.297906760364772 no 1039 0.309943170098924 1418 2970533
SGTC_653 0203-0016 55.2 µM 0.495341025884502 0.298155908208556 no 1040 0.3101797079964 1530 295302
SGTC_1774 st048371 48.465 µM 0.494522117913781 0.298460370295383 no 1041 0.310468744943606 1450 4242727
SGTC_699 0375-0592 111 µM 0.494284517803254 0.298548734194945 no 1042 0.310552628801445 1520 762578
SGTC_3117 9124945 49.47 µM 0.492875797038492 0.299072884184949 no 1043 0.311050174809528 1379 17592065
SGTC_2206 7254556 146.969 µM 0.492618884134332 0.299168520118866 no 1044 0.311140951144813 1527 4398905
SGTC_3215 9129942 49.47 µM 0.490720817487697 0.299875505841007 no 1045 0.311811960329252 1502 17682944
SGTC_420 mitomycin C 81.9 mM 0.489531303046885 0.300318957469898 no 1046 0.312232799235276 1462 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.489179895460037 0.300450019095991 no 1047 0.31235717082521 1522 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_996 3970-0799 1.8 µM 0.487881610574869 0.300934453737226 no 1048 0.312816850376127 1571 6615648 YGL040C HEM2
SGTC_270 tamoxifen 5.46 µM 0.487794197528969 0.300967083195969 no 1049 0.312847810903865 1603 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1627 st003713 25.6 µM 0.487636426383756 0.301025979896496 no 1050 0.312903694667725 1495 16195070 YER133W GLC7
SGTC_220 paclitaxel 373.376 µM 0.487413701146013 0.301109133103945 no 1051 0.312982592994077 1535 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1879 gemcitabine 100 µM 0.487316360179937 0.301145478053066 no 1052 0.313017077808278 1509 60750 A nucleoside analog which inhibits DNA replication.
SGTC_978 1416-0512 87.4 µM 0.487120616935922 0.301218570204729 no 1053 0.31308642837778 1529 6814003
SGTC_687 k029-0044 34.9 µM 0.486894058700112 0.301303178905767 no 1054 0.313166704756536 1606 5829338
SGTC_1474 0330-0125 5.35 µM 0.485731382731391 0.301737551234958 no 1055 0.313578814997855 1489 X1474
SGTC_694 1315-0438 43.2 µM 0.484072107600763 0.302357938634071 no 1056 0.314167347789286 1543 6793154
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.482982609140256 0.302765602799281 no 1057 0.314554042227998 1435 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_764 1951-2361 146 µM 0.481275324369012 0.303404922377849 no 1058 0.315160416094786 1460 5438930
SGTC_2623 humulene 100 µM 0.480416799582274 0.303726638213172 no 1059 0.315465525533466 1455 6187145 An anti-inflammatory.
SGTC_262 fenpropimorph 62.5 µM 0.478886171332315 0.304300589344327 no 1060 0.316009804634619 1471 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2271 7849410 118.62 µM 0.477830747224767 0.304696630731258 no 1061 0.316385337497873 1535 972430
SGTC_3273 9137859 49.47 µM 0.476346255811668 0.305254064500638 no 1062 0.316913858311267 1566 2377234
SGTC_438 sphingosine 6.67 µM 0.473962518017449 0.306150114955909 no 1063 0.317763317989148 1368 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_134 0269-0018 6.916 µM 0.472962721868183 0.306526285677562 no 1064 0.318119887576131 1464 4378915
SGTC_1100 amiodarone 5.07 µM 0.472864881965277 0.306563108650099 no 1065 0.318154790487061 1578 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3327 9140648 26.9345 µM 0.472783430595545 0.30659376513287 no 1066 0.318183848267508 1591 8029710
SGTC_2772 vinpocetine 57.06 µM 0.470277610544745 0.30753756042471 no 1067 0.319078345736084 1573 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1927 st060202 13.8 µM 0.470087406436565 0.30760925130264 no 1068 0.319146285631211 1562 688887
SGTC_1064 honokiol 6.76 µM 0.468065684077235 0.308371723521374 no 1069 0.319868809178987 1515 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2246 7293507 91.5585 µM 0.467453363337472 0.308602817512273 no 1070 0.320087775558185 1658 887656
SGTC_2519 cryptotanshinone 88.04 µM 0.467053556052815 0.308753748414376 no 1071 0.320230780788676 1594 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2844 9010103 25.97 µM 0.464334978122499 0.309780892128049 no 1072 0.321203883709385 1523 2480525
SGTC_3263 9137018 49.47 µM 0.464158828868152 0.309847496903548 no 1073 0.321266978016397 1459 43844957
SGTC_2018 5133068 143 µM 0.463614874575786 0.310053213884386 no 1074 0.321461847724849 1513 785362
SGTC_216 k038-0035 28.382 µM 0.463090854014011 0.310251448413559 no 1075 0.321649622725861 1522 4444231 YPR107C YTH1
SGTC_585 0kpi-0023 191 µM 0.461972686244778 0.310674630383371 no 1076 0.322050453893789 1607 64601
SGTC_1209 2323-2347 50.3 µM 0.461509883745585 0.310849856062548 no 1077 0.322216415977038 1558 5412760
SGTC_183 3914-0051 30.55 µM 0.461310873443148 0.310925218277218 no 1078 0.322287792449034 1676 1596232
SGTC_1902 st060212 70.5 µM 0.460889717658089 0.311084729799879 no 1079 0.322438864596532 1508 688944
SGTC_2275 7947463 200 µM 0.45935510760997 0.311666258983776 no 1080 0.322989590184469 1523 1225414
SGTC_331 k048-0133 24.5 µM 0.457791115009352 0.312259406117017 no 1081 0.323551259868986 1519 6813582
SGTC_94 0334-0113 514.748 µM 0.455896757879044 0.312978496634828 no 1082 0.324232110518867 1476 6795178
SGTC_3335 9143315 29.6265 µM 0.455828223027062 0.313004525557505 no 1083 0.324256753658864 1523 4899691
SGTC_1844 rapamycin 4 nM 0.451618616793588 0.314605078952587 no 1084 0.325771878019202 1549 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1203 3992-3522 103 µM 0.450612902599068 0.314987983737466 no 1085 0.32613428285878 1766 5322312
SGTC_1555 citronellol 128 µM 0.450475636059987 0.315040260557492 no 1086 0.326183759020557 1664 8842 A terpine precursor.
SGTC_2740 felodipine 17.08 µM 0.450000875741042 0.315221097640519 no 1087 0.326354904559724 1644 3333 L-type calcium channel blocker
SGTC_1629 st005085 44.9 µM 0.449738674406346 0.315320989599213 no 1088 0.326449440749232 1497 24207091
SGTC_536 3852-0578 10.6 µM 0.449378552456577 0.315458208797401 no 1089 0.326579300199327 1647 2869208
SGTC_1299 1079-1439 3.74 µM 0.444701584089234 0.317242605345313 no 1090 0.328267712198057 1507 323161
SGTC_2926 9010726 65.15 µM 0.444144322025689 0.317455501302393 no 1091 0.328469121908976 1513 2994293
SGTC_2686 alizarin 95.37 µM 0.443136502854499 0.317840681094383 no 1092 0.32883350183055 1500 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1938 st074717 56.4 µM 0.440356021013325 0.318904378763719 no 1093 0.3298396361332 1512 17250979
SGTC_328 k915-0120 63.5 µM 0.439861370005474 0.319093768551159 no 1094 0.330018757948344 1645 6624543
SGTC_2262 9014885 67.46 µM 0.432158840917576 0.322048946816769 no 1095 0.332812985740551 1642 6457424
SGTC_3112 9123419 49.47 µM 0.431601525725084 0.322263208331436 no 1096 0.333015524680678 1594 17015854
SGTC_1125 tnp00248 1.32998 µM 0.430925948900884 0.322523015087354 no 1097 0.33326110747204 1766 24207736
SGTC_1293 1000-1278 195 µM 0.43079944423898 0.322571674658375 no 1098 0.333307101855718 1650 678847
SGTC_1720 st037298 9.481 µM 0.430275946331105 0.322773068580572 no 1099 0.333497461117427 1566 597396
SGTC_544 k015-0020 52.4 µM 0.430188330694547 0.32280678011236 no 1100 0.33352932493439 1597 3008304
SGTC_2050 5263056 171 µM 0.427712408180078 0.323760032427122 no 1101 0.334430257478788 1695 763468 YGL055W OLE1
SGTC_652 0437-0092 114 µM 0.427179015320938 0.323965545179745 no 1102 0.334624472278794 1543 3091274
SGTC_163 TUB2.036 7.546 µM 0.427012199160926 0.324029829366351 no 1103 0.334685221150225 1592 15992207 YJR013W GPI14
SGTC_50 0929-0078 56.389 µM 0.424171096385463 0.325125479680535 no 1104 0.3357205191876 1641 1377751
SGTC_2051 5263410 176 µM 0.423219732058095 0.325492705115416 no 1105 0.336067475760597 1608 227584
SGTC_1945 st075991 56.6 µM 0.422714058196746 0.325687963591101 no 1106 0.336251948717844 1549 1084980
SGTC_933 2914-0560 114 µM 0.422686805982052 0.325698487989232 no 1107 0.336261891614876 1747 463887
SGTC_381 3461-2219 42.7 µM 0.42125837259909 0.326250321930154 no 1108 0.336783211872159 1691 2883159
SGTC_2600 tangeritin 87.95 µM 0.420716056480338 0.326459929832513 no 1109 0.336981217492462 1521 68077 A bioactive flavone.
SGTC_1810 st050138 53 µM 0.420276057801544 0.326630031808116 no 1110 0.337141899084454 1673 3444541
SGTC_570 0987-0065 62.6 µM 0.419652499513973 0.326871159035364 no 1111 0.337369665065062 1613 3104428
SGTC_1653 st012112 65 µM 0.419337261702755 0.326993087626556 no 1112 0.33748483408595 1659 720429
SGTC_3205 9113483 49.47 µM 0.419170157760698 0.327057728063511 no 1113 0.337545890035871 1714 17018033
SGTC_1507 4075-3230 155 µM 0.417348895825551 0.327762578760361 no 1114 0.338211614420271 1595 659771
SGTC_615 k087-0205 167 µM 0.416511872833191 0.328086723052447 no 1115 0.33851774064318 1533 9642773
SGTC_32 0928-0142 34.1 µM 0.415831194673032 0.328350416975175 no 1116 0.338766765239909 1637 2244242
SGTC_1208 2323-2347 50.3 µM 0.411774367895128 0.329923797229798 no 1117 0.340252405177446 1706 5412760
SGTC_1231 0242-0792 125 µM 0.410889193555686 0.330267500477042 no 1118 0.340576893367787 1578 3707635
SGTC_504 lovastatin 124 µM 0.410454240572437 0.330436440343617 no 1119 0.340736382179124 1566 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1331 1472-0049 76.2 µM 0.409754777786506 0.33070819079796 no 1120 0.34099292130419 1575 24051409
SGTC_1122 capsaicin 818.572 nM 0.409716383071995 0.330723110232883 no 1121 0.341007005307706 1689 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3298 9116858 71.43 µM 0.409636824812231 0.330754025872134 no 1122 0.34103618968632 1686 2506942
SGTC_2589 lobaric acid 100 µM 0.409358054801954 0.33086236255252 no 1123 0.341138458471219 1561 73157 A novel microtubule depolymerizer.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.40882306907552 0.331070310451408 no 1124 0.341334754521434 1852 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2356 9061756 188.97 µM 0.408475375710855 0.331205486125774 no 1125 0.341462352601519 1707 20104043
SGTC_170 4197-0004 226 µM 0.408020818884054 0.331382241186276 no 1126 0.341629195249805 1668 218692
SGTC_1760 st045453 10.4495 µM 0.40680469165567 0.331855318577616 no 1127 0.342075720309948 1672 3323419 YIL048W NEO1
SGTC_54 0159-0055 9 µM 0.406414127751818 0.332007306127899 no 1128 0.342219170441226 1720 3319099
SGTC_1832 st054113 55 µM 0.40609288023949 0.332132339996293 no 1129 0.342337178439117 1664 1251267
SGTC_727 3032-0951 202 µM 0.404123874866638 0.332899111393841 no 1130 0.343060814610483 1653 3652836
SGTC_1957 st077035 62.4 µM 0.403632526076058 0.33309056192183 no 1131 0.343241481853221 1661 705593
SGTC_1360 1598-0022 39.8 µM 0.40302051104285 0.333329090029678 no 1132 0.343466567765059 1720 761525
SGTC_2853 9015042 58.44 µM 0.402262885337835 0.33362446214754 no 1133 0.34374528304229 1533 6457456
SGTC_539 4859-0462 2.54 µM 0.402100867263678 0.333687640798288 no 1134 0.343804897268056 1749 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_397 arbidol 50 µM 0.402081690129246 0.333695119198851 no 1135 0.343811953713333 1707 131410 A RNA synthesis inhibitor.
SGTC_3239 9133757 49.47 µM 0.401875747527752 0.333775433654973 no 1136 0.343887736070959 1671 17036923
SGTC_608 k048-0125 159 µM 0.400811651405362 0.334190536099215 no 1137 0.34427939996196 1706 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_29 0299-0004 12.984 µM 0.399429736469598 0.334729922013034 no 1138 0.34478829336279 1589 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2734 clemastine 41.6 µM 0.3979877222456 0.335293129546184 no 1139 0.345319618024666 1658 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1136 pergolide 1.05886 µM 0.397112787972793 0.335635033294758 no 1140 0.345642145105412 1630 47811 A dopamine receptor agonist.
SGTC_1379 2144-0755 36.5 µM 0.396901437011828 0.33571764470603 no 1141 0.345720072239783 1747 5392327
SGTC_581 0958-0271 211 µM 0.394127549032782 0.336802617645479 no 1142 0.346743436278625 1578 4591145
SGTC_1146 3579-1023 7 µM 0.393567764711314 0.337021735711013 no 1143 0.346950092167345 1745 X1146
SGTC_2689 tacrolimus 100 µM 0.393242833899484 0.337148949735817 no 1144 0.347070067945213 1626 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_86 0417-1630 471.922 µM 0.39229161460389 0.337521469685137 no 1145 0.347421379348636 1657 3634867
SGTC_2752 diclazuril 33.15 µM 0.392129388391234 0.337585017211585 no 1146 0.347481307038277 1709 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_92 0063-0024 660.874 µM 0.392057115838613 0.337613329429581 no 1147 0.347508006337873 1648 3594437
SGTC_2457 5731572 11.68 µM 0.390343256469894 0.338284989705847 no 1148 0.348141370541278 1765 2865357
SGTC_3067 9117431 49.47 µM 0.389881439976118 0.338466063422683 no 1149 0.348312109400417 1650 17150885
SGTC_374 0880-0231 82.3 µM 0.388756359798136 0.338907352609771 no 1150 0.348728193083197 1690 6833587
SGTC_2236 dapsone 200 µM 0.38828211124896 0.339093432989412 no 1151 0.348903636996633 1681 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1854 st056233 32.9 µM 0.387955130267527 0.339221753024538 no 1152 0.349024619440077 1758 5393174
SGTC_3018 9082602 49.47 µM 0.387035708692918 0.339582669662575 no 1153 0.349364886178861 1656 17332089
SGTC_592 k241-0073 46.5 µM 0.386595939727171 0.339755351917599 no 1154 0.349527682153943 1720 4230158
SGTC_3160 9100216 49.47 µM 0.385117543904202 0.340336113900879 no 1155 0.350075165231254 1647 17191039
SGTC_2389 9091542 195.52 µM 0.384957652896507 0.340398947020301 no 1156 0.350134395154298 1629 3626624 YOL127W RPL25
SGTC_813 k007-0158 173 µM 0.384427452167229 0.340607334186612 no 1157 0.350330828456788 1739 6523916
SGTC_576 1073-0113 22.7 µM 0.383768181292421 0.340866518240894 no 1158 0.350575136615542 1720 5439563
SGTC_2295 7971645 200 µM 0.383420048829646 0.341003412461003 no 1159 0.350704170144816 1710 2978226 YKL099C UTP11
SGTC_383 2324-0395 7.37 µM 0.383359097340442 0.341027382234991 no 1160 0.35072676327697 1724 3146421
SGTC_3193 9111931 49.47 µM 0.382656824144326 0.341303604357455 no 1161 0.350987115754793 1665 17087244
SGTC_2032 5185112 25.99 µM 0.381116234655904 0.341909855606791 no 1162 0.351558500692153 1670 5718189
SGTC_2208 7283366 200 µM 0.381038355746928 0.341940513281061 no 1163 0.351587393904062 1744 898663
SGTC_2903 5923464 63.88 µM 0.380602789042318 0.342111996913609 no 1164 0.351749005719427 1689 2876576
SGTC_315 k915-0449 187 µM 0.380266213934323 0.342244529631933 no 1165 0.35187390624006 1714 20970215 YNL149C PGA2
SGTC_1748 st037455 53.6035 µM 0.379201425162202 0.342663937965007 no 1166 0.352269146669537 1702 580690
SGTC_2755 lomerizine 42.69 µM 0.377636925073085 0.343280528846034 no 1167 0.352850165091355 1608 3949 A calcium channel blocker.
SGTC_3155 9099265 49.47 µM 0.376466297957253 0.343742162119961 no 1168 0.353285133036728 1695 25236499
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.375071045505704 0.344292680164378 no 1169 0.353803815046026 1636 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_898 1000-0849 28.3 µM 0.374156550890069 0.344653687062712 no 1170 0.354143923744525 1718 6751807
SGTC_2661 dactinomycin 12.96 µM 0.374095336317704 0.344677857251553 no 1171 0.354166694148638 1681 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_533 1222-0222 6.71 µM 0.369392428600073 0.346536659705613 no 1172 0.355917620333225 1780 3982874
SGTC_3157 9099274 49.47 µM 0.366883666464856 0.347529753219783 no 1173 0.356852897729997 1802 17217662
SGTC_1213 1315-0166 115 µM 0.366414820344304 0.347715462323091 no 1174 0.357027781265063 1586 768401
SGTC_1897 st060201 15 µM 0.364310577287157 0.348549398737764 no 1175 0.357813051137095 1636 611878
SGTC_779 1360-0071 233 µM 0.36391314568643 0.348706987939738 no 1176 0.35796143396111 1843 7566
SGTC_1348 1493-0373 93.8 µM 0.363201158542351 0.348989369674356 no 1177 0.358227311122336 1706 3010129
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.362593383750861 0.349230485860479 no 1178 0.358454326700941 1652 91467 include heat shock
SGTC_2669 eugenol 100 µM 0.360875957553775 0.34991215126783 no 1179 0.359096088641643 1790 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_122 0236-0016 402.397 µM 0.360316634773375 0.350134257242808 no 1180 0.359305180431663 1699 6808838
SGTC_1402 3909-7673 35.9 µM 0.360207484171315 0.350177606713552 no 1181 0.359345989147803 1651 5328014
SGTC_2347 9049783 174.81 µM 0.359199431102824 0.350578050047262 no 1182 0.359722951090943 1744 6467988 YPL169C MEX67
SGTC_2992 9074591 71.4286 µM 0.359179549937622 0.350585949398421 no 1183 0.359730387036386 1690 17741321
SGTC_2193 5925765 200 µM 0.355614781812539 0.35200337436444 no 1184 0.361064536052592 1758 877370
SGTC_1262 0737-0114 49.6 µM 0.354710955605284 0.352363082192155 no 1185 0.361403071294424 1819 765919
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.352065292493363 0.353416770424472 no 1186 0.362394648334301 1684 442882
SGTC_2254 7938975 95.19 µM 0.349971189713117 0.354251586471738 no 1187 0.36318015966093 1789 2969277
SGTC_920 mycophenolic acid 780.421 nM 0.349409215444935 0.354475737492763 no 1188 0.363391057933996 1659 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1041 0206-0046 107 µM 0.348947223191913 0.354660047097875 no 1189 0.363564465876385 1694 50494
SGTC_4 0960-0234 25.671 µM 0.348900669206872 0.354678621476158 no 1190 0.363581941380132 1682 6821112
SGTC_1003 4049-0218 100 µM 0.348833520848428 0.354705413325281 no 1191 0.363607148130192 1767 295161
SGTC_169 k015-0017 16.025 µM 0.3487230833368 0.354749478886568 no 1192 0.363648606432967 1774 1840002
SGTC_1142 3253-1408 9.78 µM 0.348692154543606 0.354761820101869 no 1193 0.363660217405204 1806 256655
SGTC_74 000s-0487 160.283 µM 0.346122762171625 0.355787590922655 no 1194 0.364625228861096 1694 677548
SGTC_1547 harmine 94.2 µM 0.346105484117485 0.355794492334029 no 1195 0.364631721058932 1698 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2160 5660466 132.927 µM 0.345354738966761 0.356094409744911 no 1196 0.364913849671162 1819 2859134
SGTC_346 4513-0042 7.16 µM 0.344156960985623 0.356573097965492 no 1197 0.365364123791218 1671 2827372
SGTC_2984 9022109 38.96 µM 0.34405758854994 0.356612822011733 no 1198 0.365401488674974 1742 6459207
SGTC_633 0437-0093 97.7 µM 0.340748562581023 0.357936488141408 no 1199 0.366646438226016 1692 2831118
SGTC_486 niguldipine 82 µM 0.340425311114601 0.35806588610088 no 1200 0.366768130107232 1734 1236 A calcium channel blocker.
SGTC_3015 9080845 49.47 µM 0.340243262304024 0.358138767642452 no 1201 0.366836670455201 1820 5296973
SGTC_2159 5658611 73.75 µM 0.340169485701947 0.358168304888457 no 1202 0.366864448137811 1821 793844
SGTC_2423 st077119 87.2 µM 0.339937726561016 0.358261097642405 no 1203 0.366951712476166 1694 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2409 alverine citrate 63.97 µM 0.339395200647453 0.358478349305447 no 1204 0.367156016797582 1831 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3012 9080433 71.4286 µM 0.339227885528082 0.358545359015449 no 1205 0.367219031891321 1841 17688859
SGTC_2770 toltrazuril 17.5 µM 0.337775711589126 0.359127137465701 no 1206 0.367766107291518 1841 68591 Kills coccidiodes.
SGTC_2546 rhodinyl acetate 100 µM 0.336599243540294 0.359598700732644 no 1207 0.368209513264587 1853 6708682
SGTC_2707 st078556 66.6 µM 0.336308092828626 0.359715435608695 no 1208 0.368319273901953 1855 17250899
SGTC_1764 st044502 93.5 µM 0.335628651775168 0.359987903725149 no 1209 0.368575457548364 1711 8407
SGTC_569 4130-2812 160 µM 0.335351015257156 0.360099261462385 no 1210 0.368680157380937 1829 743552
SGTC_1509 1326-1131 80 µM 0.334571685255146 0.360411907764956 no 1211 0.368974103496464 1831 768313
SGTC_1530 rhein 70.4 µM 0.332525453018221 0.361233245159293 no 1212 0.369746261684341 1753 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3232 9132874 49.47 µM 0.330785016207837 0.361932343239037 no 1213 0.370403439847349 1676 3784940
SGTC_1545 lovastatin 49.4 µM 0.329083735842316 0.362616158543361 no 1214 0.371046198569327 1759 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1853 st056710 91.2 µM 0.328745175719356 0.362752292308593 no 1215 0.371174152565618 1885 269167
SGTC_1588 farnesol 29.9 µM 0.328603084144295 0.362809431971723 no 1216 0.371227858304695 1711 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2916 7875993 68.79 µM 0.325948031939886 0.363877675757696 no 1217 0.372231837075337 1900 1299250
SGTC_1318 1280-3875 124 µM 0.324744797964597 0.364362138651225 no 1218 0.37268711336206 1775 373245
SGTC_2333 9017922 200 µM 0.323384443209172 0.364910124771733 no 1219 0.373202054836798 1864 3163164
SGTC_1950 st077106 7.18 µM 0.322966813339856 0.365078412332265 no 1220 0.373360187730216 1701 13831864
SGTC_3219 9131112 49.47 µM 0.32259547536439 0.365228068004069 no 1221 0.37350081040825 1766 17612988 YMR079W SEC14
SGTC_1695 st026914 34.495 µM 0.322421592430652 0.365298152912609 no 1222 0.373566664256534 1726 3289191
SGTC_2377 9073351 62.6 µM 0.321064159249764 0.365845431699167 no 1223 0.374080885181029 1700 7337946 YHR072W ERG7
SGTC_1270 0831-1170 17.3 µM 0.320772013274678 0.365963252473302 no 1224 0.374191584849691 1739 6764716
SGTC_2915 7971052 15.16 µM 0.320512777879646 0.366067811187791 no 1225 0.374289822760839 1813 5741558
SGTC_680 0417-1641 114 µM 0.319335793669968 0.366542655136614 no 1226 0.374735946489514 1721 2835990
SGTC_1181 1222-0449 220 µM 0.317868430740009 0.367134935976042 no 1227 0.375292370090695 1823 658318
SGTC_1710 st031758 61.5 µM 0.317200307693233 0.367404719536231 no 1228 0.37554580823095 1838 5394341
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.316958798137739 0.367502255573748 no 1229 0.37563743292149 1794 6708630 An antioxidant.
SGTC_875 0709-0210 25.7 µM 0.316708814131884 0.367603223105477 no 1230 0.375732280064362 1893 6251364
SGTC_751 0833-0568 350 µM 0.316222754667061 0.367799566754265 no 1231 0.375916718759688 1779 6954252
SGTC_1410 3909-8106 77.9 µM 0.316171467679123 0.367820286141514 no 1232 0.375936181623573 1829 1039210
SGTC_2709 st078560 56 µM 0.315820366102433 0.367962137699742 no 1233 0.376069429393421 1874 17250903
SGTC_1689 st020265 53.493 µM 0.315539395448818 0.368075668035198 no 1234 0.376176072179187 1860 5758320 YPR016C TIF6
SGTC_119 0121-0043 24.815 µM 0.315297356496425 0.368173476682104 no 1235 0.376267945966869 1792 1092378
SGTC_2270 7924575 90.91 µM 0.314849210494154 0.368354596343889 no 1236 0.37643807292137 1898 1262135
SGTC_546 peri-Naphthalide 147 µM 0.31404214357258 0.36868084882796 no 1237 0.376744515377184 1837 223824 A penicillin ester.
SGTC_566 0958-0068 16.5 µM 0.313677067614873 0.368828459942848 no 1238 0.376883159858879 1811 6815365
SGTC_3216 9129716 49.47 µM 0.311454912221072 0.369727360411047 no 1239 0.377727407136019 1702 8056934
SGTC_795 0685-0265 78 µM 0.311011637381537 0.369906758167557 no 1240 0.377895887358125 1742 302754
SGTC_1089 terbinafine 2.25 µM 0.310812527374745 0.369987349194447 no 1241 0.377971572795853 1857 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2296 7971656 126.45 µM 0.3089722397988 0.370732486989209 no 1242 0.378671321883242 1736 666570
SGTC_2198 6589944 200 µM 0.3073325169743 0.371396824336662 no 1243 0.379295143787841 1828 5290268
SGTC_1230 0170-0365 3.77 µM 0.307229521968349 0.371438565806808 no 1244 0.37933433808106 1863 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_505 gw-5074 63.9 µM 0.307127927446893 0.371479741174576 no 1245 0.379373000641179 1848 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2253 7938677 135.83 µM 0.306278358479616 0.371824121549095 no 1246 0.379696357698775 1893 2301972
SGTC_2854 9024559 71.43 µM 0.305560913245698 0.372115024295628 no 1247 0.37996949228164 1709 3163529
SGTC_334 1502-1024 68.5 µM 0.303699374207205 0.372870163210537 no 1248 0.380678467404441 1781 3296216
SGTC_184 1494-0393 24.714 µM 0.302743801320342 0.373257984263617 no 1249 0.381042557302109 1719 3090647
SGTC_1662 st014054 52 µM 0.302601735278138 0.373315653010074 no 1250 0.381096695938607 1816 2838777
SGTC_2872 9044037 25.97 µM 0.299907995165907 0.374409656288665 no 1251 0.38212366781795 1866 6465195
SGTC_2110 5483698 200 µM 0.299116690703002 0.374731219870266 no 1252 0.382425505810168 1792 2848765 YHR062C RPP1
SGTC_1762 st045503 25.4615 µM 0.298405179184333 0.375020432270629 no 1253 0.382696968309583 1754 4645554
SGTC_2289 7946404 165.07 µM 0.29802187512034 0.375176265339871 no 1254 0.382843233943987 1738 1246120 YPR165W RHO1
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.297372152073298 0.375440458132797 no 1255 0.383091200996713 1764 6857784
SGTC_1758 st042942 75.2445 µM 0.29543258253564 0.376229480190061 no 1256 0.38383172309954 1900 669317
SGTC_1143 3454-2408 5.08 µM 0.295157728258985 0.376341333586721 no 1257 0.383936696071137 1800 X1143
SGTC_1183 1254-0324 198 µM 0.292872230819733 0.377271830233102 no 1258 0.384809907611888 1882 5799357
SGTC_1920 st075728 45.7 µM 0.291378741407744 0.377880261485291 no 1259 0.3853808357107 1931 3400306
SGTC_1267 0828-0272 9.49 µM 0.290105455894106 0.378399223485187 no 1260 0.385867781001952 1900 745334
SGTC_3002 9075603 71.4286 µM 0.2899502718457 0.378462487966375 no 1261 0.385927140681865 1844 20105405
SGTC_919 tnp00227 403.569 nM 0.289276736390723 0.378737108504392 no 1262 0.386184806662113 1797 1269246 A methoxyflavone. YNL221C POP1
SGTC_272 doxorubicin 8.13 µM 0.288571891094747 0.379024560574752 no 1263 0.386454504215552 1815 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2779 methotrexate 400 µM 0.288090160955602 0.379221059674717 no 1264 0.386638861962643 1884 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_543 3844-1095 191 µM 0.287040029145769 0.379649519549948 no 1265 0.387040835215469 1873 4230703
SGTC_1097 itavastatin 7.23 µM 0.286757300432892 0.379764899783293 no 1266 0.387149079857342 1820 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2180 6301957 200 µM 0.28634977532657 0.379931227660688 no 1267 0.387305119100886 1913 845462
SGTC_944 3370-0224 231 µM 0.286078710447511 0.380041872769553 no 1268 0.387408918519108 1739 4580514
SGTC_1258 0671-0043 57.1 µM 0.285780345667059 0.380163672690033 no 1269 0.387523181249495 1747 4298767
SGTC_1856 st057054 55.7 µM 0.285648774784487 0.380217386971812 no 1270 0.387573571151529 1929 1266018
SGTC_2673 kobusone 100 µM 0.28503587674437 0.380467635211914 no 1271 0.387808327913755 1848 6710676 An epoxy ketone and protein crosslinker.
SGTC_1895 st058434 18.3 µM 0.284620648098768 0.380637202839117 no 1272 0.387967395186605 1939 5393175
SGTC_1246 0422-0085 105 µM 0.28379523565847 0.38097434599583 no 1273 0.388283652938807 1936 264295
SGTC_1632 st005650 90 µM 0.281977311907739 0.381717202950283 no 1274 0.388980453583482 1811 2759605
SGTC_2098 5376439 882.5 nM 0.280728869905209 0.382227605562056 no 1275 0.389459181916005 1906 2844116
SGTC_1709 st033179 39.1045 µM 0.279010124357338 0.382930617921585 no 1276 0.390118527534946 1800 573381
SGTC_835 0312-0010 67.2 µM 0.278950814424412 0.382954884151586 no 1277 0.390141285682384 1807 1626196
SGTC_2205 7238770 200 µM 0.278332805249617 0.383207765450294 no 1278 0.390378447842323 1925 279867
SGTC_1864 st057645 30.4 µM 0.277493055099414 0.383551460016823 no 1279 0.390700768876256 1928 688666
SGTC_1615 st002656 86.5 µM 0.277161056935388 0.38368736616181 no 1280 0.390828220357564 1800 1584458
SGTC_2133 5320837 200 µM 0.274559361681092 0.384752885453733 no 1281 0.391827395729878 1906 2841355
SGTC_957 1187-1561 14.1 µM 0.274287686554546 0.384864199845717 no 1282 0.391931773246414 1882 1538454
SGTC_1883 5-benzylidenerhodanine 20 µM 0.274024916585536 0.384971874525996 no 1283 0.392032736803641 1941 1273210
SGTC_2845 9003024 42.97 µM 0.273986396306379 0.38498765964296 no 1284 0.392047537981325 1898 2990173
SGTC_25 0118-0223 35.662 µM 0.273688270979741 0.385109834027304 no 1285 0.392162096065301 1897 5333628
SGTC_2863 9028737 58.44 µM 0.273181888937989 0.385317379981744 no 1286 0.392356700604069 1950 6460917
SGTC_2822 7994718 71.43 µM 0.273169866364416 0.385322307958211 no 1287 0.392361321252049 1858 1018011
SGTC_2522 biochanin a 4.94 µM 0.272243063696535 0.3857022541555 no 1288 0.39271756589594 1877 5280373 A possible chelator.
SGTC_1596 piperlongumine 63 µM 0.272066609234094 0.385774604759267 no 1289 0.392785401702644 1954 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_612 0302-0167 22.4 µM 0.271434908141188 0.386033650070876 no 1290 0.39302827831395 1910 235821
SGTC_1217 1183-1422 255 µM 0.270593519130254 0.386378762225242 no 1291 0.393351840459139 1906 2849664
SGTC_1033 k072-0102 21.3 µM 0.270315015866074 0.386493015601802 no 1292 0.393458957115643 1948 5965931
SGTC_3338 9144300 39.5675 µM 0.26798566592576 0.387448994233637 no 1293 0.394355176127652 1887 4901274
SGTC_2969 9091408 28.7 µM 0.26594281264856 0.388287955277863 no 1294 0.395141626111922 1723 4286311
SGTC_2143 5623677 140.463 µM 0.26457778887032 0.388848835543946 no 1295 0.395667366224699 1928 5375313
SGTC_821 1114-0266 29.2 µM 0.264499645811339 0.388880951093022 no 1296 0.395697468848468 1814 3123235
SGTC_891 0929-0073 133 µM 0.263783325502574 0.389175382656401 no 1297 0.395973441979659 1914 5603632
SGTC_755 1995-0008 37.3 µM 0.263686066944158 0.389215364082329 no 1298 0.396010916320493 1944 689533
SGTC_2678 equilin 100 µM 0.263133201394946 0.389442660472499 no 1299 0.396223957180728 1958 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2355 9061122 103.12 µM 0.263037966380795 0.389481817710067 no 1300 0.396260658111783 1933 5302957
SGTC_3283 9109332 35.8195 µM 0.263008660157415 0.389493867608571 no 1301 0.396271952101837 1823 17027281
SGTC_2930 9013230 14.89 µM 0.261004226681175 0.390318286090147 no 1302 0.397044623892673 1942 2995857
SGTC_2060 5238662 140 µM 0.260608602184154 0.39048106388446 no 1303 0.397197177642123 1814 790130
SGTC_379 3970-0972 5.9 µM 0.258869654085587 0.391196772994592 no 1304 0.397867906393768 1872 2898042 YBL034C STU1
SGTC_471 1-acyl-paf 4 µM 0.258632820431723 0.391294276587994 no 1305 0.397959278785727 1787 16759367
SGTC_151 3013-0144 2.285 µM 0.258066480746329 0.391527464360952 no 1306 0.398177800028863 1955 906558 YHR107C CDC12
SGTC_2894 9048625 32.47 µM 0.256388979133651 0.3922183964244 no 1307 0.398825248451979 1970 4092861
SGTC_2659 sanguinarine 24.21 µM 0.255585835541684 0.392549316977126 no 1308 0.399135328406697 1859 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.255074996151041 0.392759839400942 no 1309 0.399332587859745 1812 229346 A bile salt which induces apoptosis.
SGTC_16 erodoxin 22.806 µM 0.254931620715383 0.392818931606336 no 1310 0.399387956575483 1904 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_88 0180-0332 8.668 µM 0.253087146373782 0.393579351817077 no 1311 0.400100435660181 1860 3101745
SGTC_2906 7926292 26.41 µM 0.252946426423441 0.393637383045175 no 1312 0.400154806309107 1851 2966319
SGTC_2774 tamoxifen 10.92 µM 0.252661169156019 0.393755026985098 no 1313 0.400265028478354 1884 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3270 9137563 49.47 µM 0.251726279525461 0.394140655982736 no 1314 0.400626321410449 1937 17015724
SGTC_1233 0325-0408 14.2 µM 0.251063609448201 0.394414061080932 no 1315 0.400882465205423 1927 12874
SGTC_1964 st076914 61 µM 0.250827319647571 0.394511562358254 no 1316 0.400973809303413 1905 24208661
SGTC_1008 4106-0037 6 µM 0.250777959456953 0.394531930900836 no 1317 0.400992891479803 1870 2905394
SGTC_1219 1469-0211 33.1 µM 0.248948933258319 0.395286883636929 no 1318 0.401700141640578 1965 6822282
SGTC_2812 7970281 58.44 µM 0.247662797795277 0.395817987272635 no 1319 0.402197659142976 1952 2233435
SGTC_927 2425-1185 123 µM 0.245496017514541 0.396713186183462 no 1320 0.403036195704694 1814 730375
SGTC_147 4466-0538 29.23 µM 0.245114752837858 0.396870761048175 no 1321 0.403183790096936 1884 6742687 YHR072W ERG7
SGTC_878 0828-0289 13.7 µM 0.244742145724823 0.397024774054578 no 1322 0.403328046318802 1836 745350 YLR208W SEC13
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.244443217602869 0.397148344281908 no 1323 0.403443786958484 1888 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_667 1498-1044 59 µM 0.242669105588965 0.397881934762848 no 1324 0.404130871156975 1877 6739982
SGTC_15 0266-0086 27.098 µM 0.242090709296638 0.398121178253802 no 1325 0.404354938513295 2005 1712902 YIL048W NEO1
SGTC_976 1348-1067 47.6 µM 0.241640736786302 0.398307327996292 no 1326 0.404529276948083 1861 5310671 YGL099W LSG1
SGTC_1420 4'-methoxyflavone 42 µM 0.241546711743992 0.398346228269299 no 1327 0.404565708632863 1994 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2225 6654152 15.4 µM 0.239511366115082 0.39918854349442 no 1328 0.405354542013432 1950 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2188 6126565 140.678 µM 0.239455071556948 0.399211847341315 no 1329 0.405376365423124 1966 874518
SGTC_2959 9079155 11 µM 0.239252376491347 0.399295758510925 no 1330 0.405454945569146 1898 16189457
SGTC_1933 st074711 15.9 µM 0.239199916364777 0.399317476574105 no 1331 0.405475283756701 2000 17250958
SGTC_1793 st048256 72.231 µM 0.239030238906335 0.399387723787148 no 1332 0.405541067502737 1938 672022
SGTC_1636 st007707 68.9 µM 0.238935627292012 0.399426894825821 no 1333 0.405577749470283 1972 403051
SGTC_2737 bleomycin 30.5 nM 0.23793015439409 0.399843242537568 no 1334 0.405967633587788 1912 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1466 k213-0079 57.5 µM 0.237810308363342 0.399892876165955 no 1335 0.40601411154606 1883 3657981
SGTC_3295 9122362 53.5725 µM 0.237490340141588 0.400025397310442 no 1336 0.406138206162235 1838 4730473
SGTC_1898 st060199 18.6 µM 0.235935979300896 0.400669330043527 no 1337 0.406741174397175 1834 688866
SGTC_913 3487-1245 167 µM 0.235137146024651 0.40100037180629 no 1338 0.407051144225257 1825 4016153
SGTC_1914 st062367 72.6 µM 0.234238517739327 0.401372854241793 no 1339 0.407399906915067 1859 978205
SGTC_2801 7907800 81.82 µM 0.233632631575831 0.40162404535666 no 1340 0.407635096197053 1868 6620925
SGTC_2880 9042983 58.44 µM 0.233617562989536 0.401630293080051 no 1341 0.407640945855783 1881 6464714
SGTC_335 4077-0256 27.6 µM 0.232341431886949 0.402159492462213 no 1342 0.40813641737989 1964 3121989
SGTC_2528 xanthyletin 44.79 µM 0.23154980954722 0.402487860910754 no 1343 0.408443847094552 1860 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3214 9129694 49.47 µM 0.231320130887682 0.402583145523991 no 1344 0.408533054280079 1996 17158655
SGTC_593 1203-0218 61.7 µM 0.23121842905153 0.402625339451916 no 1345 0.408572556784934 2009 3666956
SGTC_295 k015-0027 31 µM 0.230598990156982 0.402882355945813 no 1346 0.408813176103847 1936 3887424
SGTC_93 0109-0045 59.227 µM 0.230390452649878 0.402968891409388 no 1347 0.408894189657687 2018 88733
SGTC_256 clotrimazole 625 nM 0.229719843338374 0.403247202024942 no 1348 0.409154737234948 1917 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3243 9134147 49.47 µM 0.229556777193162 0.403314883773596 no 1349 0.409218098360157 2025 24282180
SGTC_1467 k284-1082 293 µM 0.228933760361191 0.403573497938969 no 1350 0.409460200158224 2013 3334705
SGTC_2950 9072895 21.46 µM 0.226742060919038 0.40448360632494 no 1351 0.410312159447489 1839 17332245
SGTC_609 0986-0026 86.3 µM 0.226504489385055 0.404582289617039 no 1352 0.410404533967576 1931 2848610
SGTC_551 k048-0028 34.9 µM 0.226113978061546 0.404744514758731 no 1353 0.41055638659475 1986 6836383
SGTC_2276 7947513 42.08 µM 0.225560035381677 0.404974660186614 no 1354 0.410771813462964 1739 2105100
SGTC_2650 prasterone 100 µM 0.22452502951576 0.405404759975642 no 1355 0.41117439664017 1950 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_844 0330-0132 15.3 µM 0.22379032259151 0.405710139008232 no 1356 0.41146023023086 2003 2828079
SGTC_643 k048-0106 28.4 µM 0.221374828490796 0.406714536458371 no 1357 0.412400295093782 1981 6763920
SGTC_1131 3454-3128 32.3 µM 0.22040548111592 0.407117778147301 no 1358 0.412777688527845 1962 710982
SGTC_3116 9124943 49.47 µM 0.219330852332513 0.407564931241334 no 1359 0.41319616512969 1805 41905195 YPL160W CDC60
SGTC_3159 9100096 49.47 µM 0.217968515455235 0.408131972776307 no 1360 0.413726821326175 1960 25236875
SGTC_1681 tripelennamine 100 µM 0.216930147570254 0.408564298946002 no 1361 0.414131391310596 2021 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1816 st051957 91.6 µM 0.216179371889278 0.408876954989695 no 1362 0.41442396611508 1941 674121
SGTC_1502 4534-4282 27.7 µM 0.216151455589562 0.40888858168529 no 1363 0.414434845921633 1919 3278949
SGTC_2418 pentamidine 31.67 µM 0.215586290501632 0.409123981198736 no 1364 0.414655121556614 2048 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2603 homopterocarpin 100 µM 0.213991403475317 0.40978845143311 no 1365 0.415276880473465 1897 101795 A weak amylase inhibitor.
SGTC_305 1682-2595 20.8 µM 0.212742333785794 0.410309026500515 no 1366 0.415763972464849 1957 226033
SGTC_1912 st060209 90.8 µM 0.210407621133138 0.411282488460915 no 1367 0.416674772493702 1870 688787
SGTC_2902 5787006 60.46 µM 0.209111709538144 0.411823056998166 no 1368 0.417180516943681 1898 591003
SGTC_26 0302-0163 425.158 µM 0.208680573613645 0.412002935525391 no 1369 0.417348803138541 1949 3100915
SGTC_1470 k295-0292 231 µM 0.207695304062027 0.412414079035148 no 1370 0.417733442272123 2016 5045612
SGTC_1399 3562-5772 25 µM 0.207380119369646 0.412545622892716 no 1371 0.417856503781175 1952 23847490
SGTC_141 0443-0274 32.331 µM 0.206940746204786 0.412729013799439 no 1372 0.418028067171721 2074 1627241
SGTC_306 1672-3436 11.6 µM 0.20571773352471 0.413239589880877 no 1373 0.418505702740433 1985 6797378
SGTC_1768 st044301 37.178 µM 0.204928994479867 0.413568945884023 no 1374 0.418813800805249 1916 3931349
SGTC_2993 9054257 71.4286 µM 0.202615455448498 0.414535366961305 no 1375 0.41971780443224 1983 6470217 YGL055W OLE1
SGTC_1673 st016611 27.3 µM 0.202434945847204 0.414610792019572 no 1376 0.41978835552774 2025 5226799
SGTC_3003 9075612 71.4286 µM 0.201857703434335 0.414852011071137 no 1377 0.420013984557591 1956 6501993
SGTC_579 4491-1009 110 µM 0.201439139933276 0.415026941193429 no 1378 0.42017760658061 2117 1271041
SGTC_2917 7979103 53.79 µM 0.201190622075313 0.41513081216326 no 1379 0.420274762036107 2017 2980565
SGTC_1508 1080-0625 72.9 µM 0.201169799950233 0.415139515285468 no 1380 0.420282902448615 2046 767111
SGTC_336 4111-0029 111 µM 0.196242309247 0.417200243692301 no 1381 0.422210256916057 1936 3131175
SGTC_1981 st071826 47 µM 0.196137072719975 0.417244279744869 no 1382 0.422251439964413 1952 11838600
SGTC_3080 9117754 49.47 µM 0.195372729822801 0.417564148897074 no 1383 0.4225505818395 2068 9550191
SGTC_2265 7929201 200 µM 0.195348898737743 0.417574122823904 no 1384 0.422559909361327 1995 1265108
SGTC_2489 cantharidin 73.42 µM 0.195214273615986 0.417630467922759 no 1385 0.422612602647852 1988 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_368 fentichlor 4.58 µM 0.194183402172051 0.418061977941088 no 1386 0.423016139329015 1921 7329 A pesticide.
SGTC_1697 st025554 27.742 µM 0.194106687720896 0.418094093610444 no 1387 0.423046172588568 1950 1269519
SGTC_3045 9092950 49.47 µM 0.193286223910841 0.418437605960961 no 1388 0.42336740731268 2097 44120432
SGTC_657 3534-0529 86.7 µM 0.192687105041929 0.418688484776979 no 1389 0.423602011444929 2060 1049549
SGTC_2990 9074105 71.4286 µM 0.191370429576202 0.419239953850588 no 1390 0.424117692841112 2030 6502001
SGTC_1783 st039459 87.517 µM 0.191226383520577 0.419300294953682 no 1391 0.424174116976815 2074 729761
SGTC_1995 st072814 61.1 µM 0.190815728778229 0.419472329238716 no 1392 0.424334982660922 1910 5769371
SGTC_495 decylubiquinone 155 µM 0.190244894659259 0.419711492525163 no 1393 0.424558616308624 1926 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1786 berberine 21.6 µM 0.189940508676167 0.41983903373826 no 1394 0.424677874452838 1984 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_51 1013-0126 23.419 µM 0.188508627950847 0.420439120914612 no 1395 0.425238976318341 2124 1627850
SGTC_1940 st075990 51.1 µM 0.187584819533385 0.420826378218173 no 1396 0.425601063623447 2021 1084979
SGTC_3278 9139605 49.47 µM 0.185823922205633 0.421564752243271 no 1397 0.42629142202444 2053 7958859
SGTC_968 1309-0633 340 µM 0.184671957921576 0.422047939783042 no 1398 0.426743171085539 2090 3761976
SGTC_2647 atorvastatin 60.16 µM 0.184118338646087 0.422280195322722 no 1399 0.426960310126745 2046 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2350 9023895 38.85 µM 0.183110147000747 0.42270322340581 no 1400 0.42735579711441 2014 2997209
SGTC_712 r015-0009 80.6 µM 0.182117541992292 0.423119798582982 no 1401 0.427745241210619 2035 6813872 YLR060W FRS1
SGTC_2397 5161689 200 µM 0.180419377916971 0.423832680974801 no 1402 0.428411671281415 2032 2259942
SGTC_1244 0416-0015 52.5 µM 0.178661218422745 0.424571011894404 no 1403 0.429101861184621 1971 96201
SGTC_1561 5-methoxyflavone 52.9 µM 0.178350643658267 0.424701463912433 no 1404 0.429223804211023 2097 94525
SGTC_1173 0443-0020 122 µM 0.177975849789127 0.424858901130485 no 1405 0.429370971002937 1944 5331295
SGTC_3028 9087778 49.47 µM 0.177441260410696 0.425083483342486 no 1406 0.429580900180731 2006 17217395
SGTC_1199 1638-0010 4.46 µM 0.176675731670563 0.425405126027362 no 1407 0.429881552149635 1931 3111136
SGTC_3081 9117243 49.47 µM 0.175295287906668 0.425985255260489 no 1408 0.4304238070759 2094 45595589
SGTC_3356 9151811 4.48 µM 0.175279131864134 0.425992045761922 no 1409 0.430430154142759 1971 1859254 YPR165W RHO1
SGTC_3013 9080133 71.4286 µM 0.174920377031203 0.426142838661354 no 1410 0.430571099282971 2051 17050193
SGTC_2395 5646831 180.19 µM 0.174792338268702 0.426196658911235 no 1411 0.430621404417165 2020 6808628
SGTC_1901 st060216 58.6 µM 0.174632116752803 0.42626400890555 no 1412 0.430684355415318 2034 688792
SGTC_3220 9131269 49.47 µM 0.17445437394993 0.426338726585172 no 1413 0.430754192584022 2093 17722206
SGTC_2792 7535235 81.82 µM 0.172981326142207 0.426958052684643 no 1414 0.431333052962148 1922 1281891
SGTC_863 0466-0191 129 µM 0.1722442749413 0.427268005127797 no 1415 0.431622745810249 2111 765160 YPR165W RHO1
SGTC_3256 9138902 49.47 µM 0.171846492782028 0.427435303290725 no 1416 0.431779106612276 2093 17228773
SGTC_1241 0364-0022 50.8 µM 0.170608900559609 0.427955889864392 no 1417 0.432265649453407 2030 4563895
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.169937323720453 0.428238437640425 no 1418 0.432529713961129 1994 15053
SGTC_2326 6164455 177.58 µM 0.168451387267117 0.428863735747041 no 1419 0.433114092217985 1984 2888790
SGTC_1051 3253-3903 78 µM 0.166094315887745 0.429855982560619 no 1420 0.434041363645538 2082 5509239
SGTC_1031 k035-0009 16 µM 0.166014610674141 0.429889543524519 no 1421 0.434072726036129 2111 5180959
SGTC_1112 tnp00069 1.16933 µM 0.165995029889816 0.429897788357513 no 1422 0.434080430742509 2097 145826
SGTC_2958 9077254 16.72 µM 0.164990197550647 0.43032093161297 no 1423 0.434475848770164 2006 16457351
SGTC_1012 4112-3522 18 µM 0.164803276681814 0.430399654388207 no 1424 0.434549412445656 2116 3112398
SGTC_2596 sinensetin 100 µM 0.163476022555019 0.430958714308753 no 1425 0.435071825205883 1997 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3086 9117350 49.47 µM 0.162531666657122 0.431356575906294 no 1426 0.435443596702645 2108 2679265
SGTC_967 1306-0166 352 µM 0.162069985558009 0.431551109709056 no 1427 0.435625370868593 2117 4437607
SGTC_3021 9087658 49.47 µM 0.161274928178952 0.431886153724274 no 1428 0.435938434584949 2136 25237042
SGTC_234 nsc-17383 10.7 µM 0.160728589154834 0.432116414105531 no 1429 0.436153585643187 2106 408974
SGTC_780 0109-0199 192 µM 0.160099898094099 0.432381411159764 no 1430 0.436401190724437 2141 610414
SGTC_647 0140-0236 81 µM 0.159874845260424 0.432476279679557 no 1431 0.436489832094216 2057 990837
SGTC_176 1486-1328 72.834 µM 0.159473008317325 0.43264567925241 no 1432 0.436648111200637 1981 22310231
SGTC_2241 6772625 37.8075 µM 0.159165280568806 0.432775414246495 no 1433 0.436769328600524 2173 2285411
SGTC_954 1189-0853 2.85 µM 0.158230806060464 0.433169423873024 no 1434 0.437137464898665 2137 2828194
SGTC_856 0433-0016 11.3 µM 0.157889412587488 0.433313384802146 no 1435 0.437271970474574 2022 3911780
SGTC_1427 4048-4900 550 nM 0.157792290251295 0.433354341572305 no 1436 0.437310237018242 2140 24132586
SGTC_2568 diosmetin 100 µM 0.157477178749513 0.433487229930402 no 1437 0.437434396099668 2163 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_167 3672-0051 66.205 µM 0.157402928228949 0.433518543845752 no 1438 0.437463652915604 2064 3237971
SGTC_1393 3470-5649 58.2 µM 0.157257141313278 0.43358002825336 no 1439 0.437521098099522 2033 4108395
SGTC_3198 9112019 49.47 µM 0.15722302815018 0.433594415425586 no 1440 0.437534540078491 2057 45595555
SGTC_464 bw-b 70c 158 µM 0.156741778904957 0.433797390896352 no 1441 0.437724179604216 2122 5353454
SGTC_2338 7999974 200 µM 0.156055951218101 0.434086681137979 no 1442 0.437994459360243 2142 315925
SGTC_679 0422-0091 41.4 µM 0.155918013299108 0.434144869255466 no 1443 0.43804882319977 2011 627384 YHR062C RPP1
SGTC_693 4161-2696 114 µM 0.15547032774696 0.434333732005424 no 1444 0.438225272258342 2097 805759
SGTC_3333 9141820 12.094 µM 0.155349426938975 0.434384738365822 no 1445 0.438272925744629 2004 1939433
SGTC_1475 4092-1048 11.7 µM 0.153704873230067 0.435078660715192 no 1446 0.438921221082963 2044 2881759
SGTC_1380 2291-0730 164 µM 0.152557080541217 0.435563092507419 no 1447 0.4393737867355 1997 2999191
SGTC_731 3966-0296 387 µM 0.151248125761806 0.436115661581027 no 1448 0.439889994028814 2077 660956
SGTC_3093 9117344 49.47 µM 0.150469974405642 0.436444213676066 no 1449 0.440196918982171 2070 24824913
SGTC_1168 k815-0004 80.5 µM 0.150293027796671 0.43651893043526 no 1450 0.440266716762612 2050 642433
SGTC_1527 coumarin 137 µM 0.149507124747355 0.436850810010966 no 1451 0.440576743909144 2081 323 A hepatotoxic, DNA x-linker.
SGTC_2675 theaflavin digallate 100 µM 0.149168118731275 0.436993982846435 no 1452 0.440710488033298 2103 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3223 9129970 49.47 µM 0.148596184593934 0.43723554720349 no 1453 0.440936141919 2054 17248386
SGTC_2491 paeonol 100 µM 0.148335725221434 0.437345563611038 no 1454 0.441038911282018 2024 11092 Increases levels of cortical cytochrome oxidase.
SGTC_947 3447-0010 211 µM 0.146477498117712 0.438130607182659 no 1455 0.441772226108375 2144 748350
SGTC_714 4296-0578 26.1 µM 0.145996385214111 0.438333902343136 no 1456 0.441962121016725 2141 1589775
SGTC_165 k038-0023 64.381 µM 0.145485748448672 0.438549690667962 no 1457 0.442163683562377 2073 46368543
SGTC_1353 1498-1206 8.11 µM 0.143587718079556 0.439351932784576 no 1458 0.442913019850696 2095 6756808
SGTC_62 0180-0423 3.232 µM 0.141342998866451 0.440301031502357 no 1459 0.443799491187647 2102 30102 YGL099W LSG1
SGTC_2202 7226349 200 µM 0.140727640040103 0.44056127398364 no 1460 0.444042554395904 2121 844334
SGTC_1017 4239-0030 168 µM 0.140478189591458 0.440666776830677 no 1461 0.44414109189402 1962 1149593
SGTC_2472 5377652 49.4 µM 0.140086931729895 0.440832264341991 no 1462 0.444295652871889 2007 1610903
SGTC_1609 st001574 46.4 µM 0.140068145210936 0.440840210600421 no 1463 0.444303074438321 2100 3960012
SGTC_901 1112-0062 60.1 µM 0.140050757079291 0.440847565394928 no 1464 0.444309943592812 2119 1908457
SGTC_2101 5377231 179.231 µM 0.139750324209503 0.440974645063375 no 1465 0.444428631772641 2110 2844213
SGTC_2942 9052777 62.25 µM 0.138311533751122 0.441583321005001 no 1466 0.444997105252483 2089 6469503
SGTC_975 1335-0046 28.5 µM 0.136924861328116 0.442170079165873 no 1467 0.445545093707825 2008 16486740
SGTC_2293 7624732 200 µM 0.136451190087708 0.442370538099942 no 1468 0.445732304112842 2121 894453
SGTC_1130 3454-2858 15.9 µM 0.136355641080016 0.442410976485425 no 1469 0.445770069681518 1976 715628 YIL048W NEO1
SGTC_2124 5246320 200 µM 0.135524661031902 0.442762690287693 no 1470 0.446098533720415 2077 579342
SGTC_1433 4060-0023 7.6 µM 0.134201230069495 0.443322927849672 no 1471 0.446621726628681 2138 3840627
SGTC_1425 4048-4433 7.33 µM 0.133861831342815 0.443466621129246 no 1472 0.446755916377943 2160 23734946
SGTC_2072 5231554 129 µM 0.132938527347387 0.443857563459839 no 1473 0.447120998443001 2197 789545
SGTC_1799 st045822 46.1415 µM 0.132535946522809 0.444028040032781 no 1474 0.447280196291081 2167 3674992
SGTC_2946 9065502 71.43 µM 0.132447264330429 0.444065594720352 no 1475 0.447315266203279 2196 16489101
SGTC_1755 st041960 45.185 µM 0.132168847808738 0.444183500406844 no 1476 0.447425370385055 2075 2257073
SGTC_1557 sumaresinolic acid 42.3 µM 0.131926510643668 0.444286130988288 no 1477 0.44752120971761 2091 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2626 ethyl orsellinate 100 µM 0.131756312292206 0.444358212780069 no 1478 0.447588521474619 2088 75653 A natural product.
SGTC_1386 3228-0095 33.8 µM 0.129237465784746 0.445425199463812 no 1479 0.448584875686214 2145 870181
SGTC_582 0987-0078 156 µM 0.128349025994996 0.445801638458873 no 1480 0.448936384386729 2180 1625765
SGTC_876 0720-0963 56.8 µM 0.128343676356641 0.445803905291468 no 1481 0.448938501077761 2197 765861
SGTC_1805 st050013 60.3 µM 0.127542599326375 0.446143370158008 no 1482 0.449255479539428 2134 4037144
SGTC_2762 leflunomide 42.06 µM 0.127415250407145 0.446197339253055 no 1483 0.44930587326843 2069 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2646 retinol 96.75 µM 0.12557370282282 0.44697787813285 no 1484 0.450034690126521 2145 445354 A vitamin A analog and teratogen.
SGTC_2833 9001315 45.46 µM 0.125199917881474 0.44713633184246 no 1485 0.450182641127406 2033 2989378
SGTC_1490 4089-0339 670 nM 0.124057400239435 0.447620716456929 no 1486 0.450634913605651 2195 742542
SGTC_1308 1187-1617 41.4 µM 0.123995505627677 0.447646959687444 no 1487 0.450659416795684 2113 2882570
SGTC_1654 st012436 41.8 µM 0.123356911480176 0.447917736089986 no 1488 0.450912238032072 2169 4323132
SGTC_500 h-89 112 µM 0.123232806854387 0.447970361698133 no 1489 0.450961373720429 2195 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2449 5812982 45.77 µM 0.12313035291287 0.448013807190917 no 1490 0.451001938003905 2186 776185
SGTC_189 3970-0742 2.116 µM 0.123071099901624 0.448038933656504 no 1491 0.451025398105497 2202 2891807
SGTC_2857 9024691 58.44 µM 0.122753884455739 0.448173453620323 no 1492 0.451150996428913 2089 16478292
SGTC_18 0111-0177 500 nM 0.1227067981647 0.448193421776062 no 1493 0.45116964019806 2148 721752
SGTC_774 k060-0086 136 µM 0.122462175437476 0.448297162461934 no 1494 0.451266500051218 2201 5911235
SGTC_2909 7941780 10.49 µM 0.121709960816248 0.448616187081532 no 1495 0.451564362149916 2191 1243215
SGTC_3122 9126309 49.47 µM 0.12140084014971 0.448747299074911 no 1496 0.451686775730015 2214 17591206
SGTC_2586 curcumin 80 µM 0.121283789965278 0.448796946790363 no 1497 0.4517331294829 2157 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1022 4477-0945 21.3 µM 0.121084924791125 0.44888129878656 no 1498 0.451811884794099 2061 4648966
SGTC_1556 plumbagin 1.48 µM 0.120535872298632 0.449114200587456 no 1499 0.452029332400174 2193 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1408 3909-7976 48.8 µM 0.11875811071518 0.449868426655434 no 1500 0.452733498277949 2116 24152374
SGTC_1245 0418-0076 17.2 µM 0.118376298476417 0.45003043651974 no 1501 0.452884752397919 2096 6790114
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.117979725644672 0.450198718388708 no 1502 0.45304186113365 2124 688664
SGTC_1870 st057514 26.5 µM 0.117965690066922 0.450204674415453 no 1503 0.453047421689413 2139 5393161
SGTC_1606 st000094 49.2 µM 0.117893113675214 0.450235472537828 no 1504 0.453076174843843 2208 1242210
SGTC_702 1488-0190 94 µM 0.116439685101368 0.450852304424798 no 1505 0.453652042560307 2224 949357
SGTC_1147 3809-1045 12.3 µM 0.112910632127587 0.452350517900233 no 1506 0.45505070350979 2064 325925
SGTC_994 3910-0338 138 µM 0.112622328723456 0.452472943632853 no 1507 0.455164990956361 2169 3479481
SGTC_1377 2944-0135 198 µM 0.1115083223163 0.452946039895441 no 1508 0.455606633252246 2136 1894137
SGTC_2008 4012253 172 µM 0.110489791110891 0.453378648222648 no 1509 0.456010472906029 2142 603940
SGTC_521 r062-0005 13.8 µM 0.11037282221136 0.453428332844203 no 1510 0.456056853076761 2067 2832033
SGTC_2640 pentamidine 10.38 µM 0.109538210242539 0.453782870242249 no 1511 0.456387808349705 2219 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1395 3486-0190 4.35 µM 0.109258102725136 0.453901866249829 no 1512 0.456498888387804 2212 6748079
SGTC_3000 9075062 71.4286 µM 0.108763083894917 0.454112171555408 no 1513 0.456695202424422 2096 17057871
SGTC_2027 5150920 200 µM 0.107799766867836 0.454521466919735 no 1514 0.457077263912967 2176 786715
SGTC_2705 st078069 42.8 µM 0.107716666175169 0.454556777116652 no 1515 0.457110224370522 2137 1530061
SGTC_2348 9022543 33.42 µM 0.107608325508401 0.45460281253424 no 1516 0.457153196271841 2141 3162678 YDL140C RPO21
SGTC_1719 st032227 49.2 µM 0.10708828699883 0.454823792421969 no 1517 0.457359469675679 2132 3125804
SGTC_2290 7904846 200 µM 0.106524975252361 0.455063176172717 no 1518 0.45758292037927 2113 2962154
SGTC_2966 9084041 48.03 µM 0.105841760169776 0.45535353567846 no 1519 0.457853951516658 2127 17741380
SGTC_1791 st048313 56.1 µM 0.104412913035182 0.455960858191796 no 1520 0.458420837787302 2234 1204976
SGTC_3139 9095020 49.47 µM 0.101309132947118 0.457280453135257 no 1521 0.459652533227004 2244 25236292
SGTC_2892 9047358 58.44 µM 0.100641405252727 0.457564404557351 no 1522 0.459917563456546 2140 6466771
SGTC_2764 methyldopa 94.69 µM 0.0987818927916913 0.458355276558879 no 1523 0.460655722813633 2212 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2575 plumbagin 510 nM 0.0987622054109798 0.45836365071559 no 1524 0.460663538723364 2139 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1416 3966-0321 25.3 µM 0.0979855276375832 0.458694030415794 no 1525 0.460971892667173 2167 582530 YLR208W SEC13
SGTC_804 1595-0054 20.9 µM 0.09779269233864 0.4587760622591 no 1526 0.461048455119461 2084 761523 Stimulates phospholipase C.
SGTC_1256 0570-0116 285 µM 0.0951065732821108 0.459918914213513 no 1527 0.462115088510857 2150 410638
SGTC_1987 st072290 61.9 µM 0.0947186791081894 0.460083977534242 no 1528 0.462269140449901 2122 54697379
SGTC_1951 sophoraflavanone G 9.2 µM 0.0938266109612456 0.460463611588546 no 1529 0.462623446219313 2158 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2424 5537928 59.2 µM 0.093509481307811 0.460598579952667 no 1530 0.462749408852736 2153 5382802
SGTC_2789 5281112 71.43 µM 0.0933734172805311 0.460656489330093 no 1531 0.462803454087547 2141 765948
SGTC_1371 2421-0008 32.7 µM 0.0932690302579866 0.460700917417218 no 1532 0.462844917541165 2145 2827552
SGTC_3022 9087993 49.47 µM 0.0916262331996839 0.461400171369375 no 1533 0.463497504019604 2254 17173644
SGTC_2404 5161160 200 µM 0.090918568148661 0.461701424777168 no 1534 0.463778648024362 2181 2831543
SGTC_3176 9106582 49.47 µM 0.0897315860201422 0.462206772988199 no 1535 0.46425025758314 2238 17018027
SGTC_545 4218-0007 221 µM 0.0875794032692163 0.463123202743423 no 1536 0.465105486537581 2178 2840508
SGTC_1284 0929-0043 16 µM 0.0875148464682261 0.463150694987462 no 1537 0.465131142466424 2154 1239883
SGTC_1158 4092-0494 91.8 µM 0.0873096618034047 0.463238076366278 no 1538 0.465212687170948 2197 1148199
SGTC_2006 4011487 200 µM 0.0868687961389066 0.46342583250117 no 1539 0.465387901402452 2234 45595294
SGTC_101 0490-5701 117.494 µM 0.0859461833225584 0.463818781719331 no 1540 0.465754599162639 2252 4661669
SGTC_627 1391-0720 175 µM 0.0853458336504811 0.464074495105011 no 1541 0.465993227222479 2178 997839
SGTC_1275 0867-0008 21.1 µM 0.085203030360692 0.464135323033343 no 1542 0.466049990732437 2188 3422836
SGTC_1778 st046819 58.9 µM 0.084492301232054 0.464438074861812 no 1543 0.466332511840764 2257 671715
SGTC_3163 9099914 49.47 µM 0.0838209399947065 0.464724075923444 no 1544 0.46659939944946 2254 16268368
SGTC_2382 9035899 200 µM 0.0815676917177977 0.465684096024309 no 1545 0.467495246964585 2246 6462679
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0809032172276376 0.465967240748459 no 1546 0.467759460688755 2255 6708561
SGTC_2362 9071156 126 µM 0.0795034129006049 0.466563779157079 no 1547 0.468316108552925 2242 653133
SGTC_3175 9106517 49.47 µM 0.0780229076238055 0.467194790670689 no 1548 0.468904915443485 2183 41468073
SGTC_1453 4237-0541 195 µM 0.0779565060836417 0.467223093855288 no 1549 0.468931325385239 2271 739892
SGTC_1155 4088-0394 48.2 µM 0.077570570972334 0.467387599229954 no 1550 0.469084826392133 2209 2326248
SGTC_3137 9097352 49.47 µM 0.0773618850768046 0.467476554203508 no 1551 0.469167830590233 2218 44120435
SGTC_3184 9108758 49.47 µM 0.0760733441779177 0.468025846688667 no 1552 0.469680373468737 2259 902885
SGTC_73 0327-0325 16.231 µM 0.0760083303367694 0.468053563080632 no 1553 0.469706235361158 2291 53298
SGTC_258 haloperidol 50.781 µM 0.0748836247710914 0.468533066612453 no 1554 0.470153652755761 2155 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1573 oleylamine 1.06 µM 0.0746040176847572 0.468652280555075 no 1555 0.470264888692168 2231 5356789 An amine of the fatty acid oleic acid.
SGTC_1675 st018485 24.5 µM 0.0741158766660589 0.468860412252133 no 1556 0.470459091126877 2138 3323024
SGTC_962 1254-0300 21.5 µM 0.0740203584078458 0.468901139958421 no 1557 0.470497093014701 2228 7340576
SGTC_58 0957-0393 9 µM 0.0738263713978501 0.468983854423103 no 1558 0.470574271469205 2253 6997992
SGTC_3051 9093778 49.47 µM 0.0737993538342781 0.468995374596164 no 1559 0.470585020595266 2289 17217378
SGTC_1625 st003711 30.1 µM 0.072397640265927 0.469593094626979 no 1560 0.471142731331865 2249 24207034 YER133W GLC7
SGTC_131 0141-0277 33.849 µM 0.07146753075081 0.469989750716351 no 1561 0.471512832582997 2256 1547771
SGTC_3285 9112818 20.8695 µM 0.0705455064102207 0.470382988184181 no 1562 0.471879740933857 2280 17017947 YPR165W RHO1
SGTC_1385 3091-4834 14.1 µM 0.0691403080241616 0.470982351710038 no 1563 0.472438968307368 2227 4072814
SGTC_2962 9082311 13.18 µM 0.0688739742513428 0.471095959312831 no 1564 0.472544967425897 2220 16459453
SGTC_2448 5185112 27.17 µM 0.0687077369795414 0.471166870844072 no 1565 0.472611129770652 2199 5718189
SGTC_1117 retinoic acid 1.10837 µM 0.0681416480003657 0.471408353235658 no 1566 0.47283643853717 2272 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2516 gossypol 71.55 µM 0.0679730740303557 0.471480265601216 no 1567 0.472903534253916 2280 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_580 1123-0028 41 µM 0.0674013840623315 0.471724151076716 no 1568 0.47313108368704 2276 1677248 YPR107C YTH1
SGTC_1179 1021-1431 9.29 µM 0.066421966498805 0.472141999545608 no 1569 0.473520941040912 2224 2840958
SGTC_1488 4013-0813 75.9 µM 0.0663597433294322 0.472168546828742 no 1570 0.473545709846498 2195 2910057
SGTC_2843 9000894 45.46 µM 0.0662312432056059 0.472223371318492 no 1571 0.473596861447286 2303 2242070
SGTC_354 2783-3500 4.88 µM 0.0658656899547816 0.472379337237006 no 1572 0.473742378346104 2207 6740761
SGTC_1111 tnp00062 510.699 nM 0.0656032593167866 0.472491307765495 no 1573 0.473846847073189 2277 676306
SGTC_2148 5546263 113.568 µM 0.0653360224806423 0.472605331174734 no 1574 0.473953230906082 2221 792097
SGTC_21 0849-0113 22.993 µM 0.0640506364656766 0.473153805091117 no 1575 0.474464953739649 2269 1560156
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0640423994059713 0.473157320007841 no 1576 0.474468233118196 2291 6312947
SGTC_2207 7258803 200 µM 0.0636004000473457 0.473345932957404 no 1577 0.474644206598599 2278 3666799
SGTC_1524 corynanthine 62.1 µM 0.0633474620017168 0.47345387107845 no 1578 0.474744911208173 2198 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_476 mead acid 10 µM 0.0628161028218566 0.473680628245722 no 1579 0.47495647149746 2295 5312531 An omega 9 fatty acid.
SGTC_3020 9089140 49.47 µM 0.0626812673108261 0.473738170567517 no 1580 0.475010157288414 2239 17217859
SGTC_1080 nisoldipine 24.4 µM 0.0626786979403687 0.473739267075836 no 1581 0.47501118030734 2290 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1322 1348-1070 12 µM 0.0611762620002193 0.474380482647009 no 1582 0.475609417247636 2279 6758089
SGTC_3269 9137823 49.47 µM 0.0581546350936532 0.475670263852198 no 1583 0.476812727739861 2239 17682936
SGTC_2324 6149169 200 µM 0.0566379926760508 0.476317739503232 no 1584 0.477416784663301 2278 2888231
SGTC_3143 9086658 49.47 µM 0.0561437597541143 0.476528747974041 no 1585 0.477613641825181 2194 25236626
SGTC_40 0327-0103 19.753 µM 0.0555633384859881 0.476776562212659 no 1586 0.477844835506752 2281 409036
SGTC_1997 st073024 93.8 µM 0.0553753702479289 0.476856818275873 no 1587 0.477919708708749 2315 686268
SGTC_2657 nystatin 74.44 µM 0.0549122702530015 0.477054550267513 no 1588 0.478104178190635 2272 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_881 0833-0569 170 µM 0.0537094106755419 0.477568167174244 no 1589 0.478583342495582 2224 5418700
SGTC_767 0929-0023 86 µM 0.0535981926172695 0.477615658797954 no 1590 0.47862764826325 2308 1204563
SGTC_142 0335-0849 62.6745 µM 0.0523882299144555 0.478132349728444 no 1591 0.479109676203522 2307 3889043 YPR107C YTH1
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0522036493574456 0.478211174501668 no 1592 0.479183212566942 2270 688803
SGTC_768 0384-0033 77.3 µM 0.0519360371609889 0.478325459290299 no 1593 0.479289829754615 2208 3965305 YMR134W ERG29
SGTC_2181 6316240 54.2555 µM 0.0510632080842179 0.478698216546325 no 1594 0.479637576710803 2245 12779990
SGTC_2331 7980721 200 µM 0.0507881158603634 0.478815703474112 no 1595 0.479747180412993 2268 2981221
SGTC_894 0960-0238 55.9 µM 0.050758514807868 0.478828345659681 no 1596 0.479758974312654 2306 6741907 YDL195W SEC31
SGTC_1458 k015-0034 6.33 µM 0.0498961833502411 0.479196644371337 no 1597 0.480102559381191 2193 3598957
SGTC_1063 disulfiram 1.84 µM 0.0494568550339701 0.479384286789258 no 1598 0.480277609895787 2316 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2135 5326629 150.42 µM 0.0491740397262691 0.479505083035164 no 1599 0.480390299764217 2275 5020077
SGTC_3337 9144342 33.5465 µM 0.0484988956073551 0.479793458590854 no 1600 0.480659322292712 2307 17682949
SGTC_1976 st070609 63.5 µM 0.0480473223370688 0.479986345828864 no 1601 0.480839264180547 2311 682556
SGTC_2979 9012552 45.46 µM 0.0470973733606006 0.480392126973595 no 1602 0.481217810385512 2338 17100905
SGTC_3287 9117173 37.0625 µM 0.0463922569200116 0.480693338372337 no 1603 0.48149880397627 2335 2789709
SGTC_1880 MG-132 525 µM 0.0450032436873762 0.481286728651747 no 1604 0.482052361743473 2314 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2921 7974240 10.71 µM 0.0445078689114373 0.481498364219692 no 1605 0.482249789855015 2297 2979074 YDR527W RBA50
SGTC_276 colchicine 750 µM 0.0444661714522377 0.481516178577957 no 1606 0.482266408281612 2240 2833 A microtubule depolymerizer.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.043727383939389 0.481831816017718 no 1607 0.482560855430776 2297 7104
SGTC_2529 gangaleoidin 93.61 µM 0.0428477856796756 0.482207627869157 no 1608 0.482911435739814 2311 4565183
SGTC_429 1112-0049 25.5 µM 0.0423115056345657 0.482436763428894 no 1609 0.483125186665515 2269 2836170
SGTC_1777 st045864 34.765 µM 0.0413605235261368 0.482843102326521 no 1610 0.483504241756023 2334 4691462
SGTC_1988 st071872 53.4 µM 0.0410572125284458 0.482972705858797 no 1611 0.483625142637882 2344 16414116
SGTC_117 lucigenin 22.078 µM 0.0405932891675406 0.483170941864218 no 1612 0.483810067108616 2243 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2358 9037157 4 µM 0.0402932547727411 0.483299149784135 no 1613 0.48392966566264 2290 2388925
SGTC_2588 indole-3-carbinol 100 µM 0.0400827215253052 0.483389113934145 no 1614 0.484013588478151 2331 3712 Induces cell cycle arrest.
SGTC_2370 9071495 200 µM 0.0400824737108029 0.483389219829658 no 1615 0.484013687262448 2200 21791103
SGTC_1428 4049-0204 61.7 µM 0.0397817475688668 0.483517726281422 no 1616 0.484133564020577 2334 X1428
SGTC_3238 9133470 49.47 µM 0.0395377689923824 0.483621984592567 no 1617 0.484230820872446 2339 3534688
SGTC_696 1560-0013 611 µM 0.0383652515221138 0.484123046914765 no 1618 0.484698232921072 2311 1650269
SGTC_237 nikkomycin 200 µM 0.0382833085212547 0.484158065292884 no 1619 0.484730899450388 2329 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2514 salinomycin 42.74 µM 0.0372541891400313 0.484597870236592 no 1620 0.485141165942527 2344 23682228 A polyether potassium ionophore.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.035061155075377 0.485535148147241 no 1621 0.486015488056921 2303 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_179 1273-0063 6.77 µM 0.034612714259038 0.485726816681883 no 1622 0.486194281531441 2337 3108139
SGTC_185 k048-0037 25.491 µM 0.0342710982125634 0.485872829350684 no 1623 0.486330485805605 2347 6827589
SGTC_1350 1495-0454 146 µM 0.0341830550337957 0.485910460851805 no 1624 0.486365589384288 2329 1069057
SGTC_308 4092-1169 104 µM 0.0335248501244253 0.486191795386859 no 1625 0.486628024716702 2327 2268590 YDL196W YDL196W
SGTC_632 0781-2353 4.65 µM 0.0333628554798539 0.486261037327441 no 1626 0.486692615097558 2314 6811515 YHR007C ERG11
SGTC_1027 k015-0025 8.67 µM 0.0310560388408425 0.487247092022066 no 1627 0.487612424333035 2359 3598955
SGTC_1833 st055984 71 µM 0.0307791411062868 0.487365458029556 no 1628 0.487722837761777 2315 676288
SGTC_1696 st025591 34.7925 µM 0.0307225058942349 0.487389668130091 no 1629 0.487745421262269 2364 2787147
SGTC_2427 5545055 42.75 µM 0.0295560776993995 0.48788829647115 no 1630 0.488210547456956 2344 5372858
SGTC_2628 lathosterol 100 µM 0.0289574506192631 0.488144206832158 no 1631 0.488449262918753 2328 6710616
SGTC_1478 0453-0656 35.7 µM 0.0286721959428125 0.488266153635963 no 1632 0.488563015835497 2349 5258496
SGTC_2932 9016711 44.54 µM 0.0285670325291408 0.488311111431067 no 1633 0.488604952789117 2352 7117328
SGTC_1242 0402-0103 60.1 µM 0.0264195648504937 0.489229194437721 no 1634 0.489461344550927 2360 432868
SGTC_825 1988-2224 89.6 µM 0.0262956859653402 0.48928215678939 no 1635 0.489510747911991 2348 1180859
SGTC_292 k038-0015 474 µM 0.0243293203532369 0.490122868306626 no 1636 0.49029496289462 2345 46368540
SGTC_2506 ethyl hematommate 54.16 µM 0.0241162554297081 0.49021396603875 no 1637 0.490379938567809 2257 3940691 An allergen.
SGTC_1325 1431-0015 227 µM 0.023681774671705 0.490399733583216 no 1638 0.490553221817284 2363 1103340
SGTC_717 1532-0246 73.2 µM 0.0235290589359835 0.490465029554338 no 1639 0.490614129609334 2341 9561992
SGTC_2876 9059903 25.97 µM 0.0222266212272832 0.491021917113864 no 1640 0.491133591082511 2371 6916095
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0220059766519619 0.491116260601334 no 1641 0.491221594007272 2237 61125 An anti-inflammatory.
SGTC_364 0083-0097 67.7 µM 0.0203212118031788 0.491836650493613 no 1642 0.491893567354014 2347 5207356
SGTC_2571 chrysanthemic acid 100 µM 0.0191569259907353 0.492334504056049 no 1643 0.492357959685244 2329 2743 An insecticide.
SGTC_1505 k297-0037 20.6 µM 0.0182257751348398 0.492732676751142 no 1644 0.492729370232793 2368 4089396
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0173763703737737 0.493095900036414 no 1645 0.493068180010005 2376 260807
SGTC_3092 9117248 49.47 µM 0.0173704700251564 0.493098423169564 no 1646 0.493070533553319 2380 17141857
SGTC_281 1672-3440 14.9 µM 0.0166578960153953 0.493403139217177 no 1647 0.493354768304256 2359 6833000
SGTC_7 0192-1582 4.227 µM 0.0162811099709946 0.493564264755544 no 1648 0.493505063802345 2374 252616
SGTC_787 4152-0075 138 µM 0.0153594260595251 0.493958410096265 no 1649 0.49387271645969 2354 9566539
SGTC_1499 4480-0877 67.3 µM 0.0153346269135366 0.493969015190284 no 1650 0.493882608722506 2372 2861909
SGTC_2796 7949634 45.45 µM 0.0151603837450935 0.494043528568864 no 1651 0.49395211360944 2380 2971588
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0150738852655818 0.494080518870905 no 1652 0.493986617567316 2363 4213774
SGTC_3322 9139058 2.11 µM 0.0147060702905775 0.494237812223672 no 1653 0.494133338245655 2349 4908926 YPR165W RHO1
SGTC_519 k048-0011 62.8 µM 0.0140412851430339 0.494522104929759 no 1654 0.494398521748293 2324 6836379
SGTC_1671 st016596 74.5 µM 0.0134297131306786 0.494783643712121 no 1655 0.494642480663521 2379 2829167
SGTC_721 1187-1332 279 µM 0.0129998079699424 0.494967494010753 no 1656 0.494813973032879 2370 25730
SGTC_1781 st038725 66.3 µM 0.0118519880949664 0.495458367932816 no 1657 0.4952718515359 2378 4270275 YIL048W NEO1
SGTC_698 k064-0052 127 µM 0.0118394911640985 0.495463712379785 no 1658 0.495276836740221 2391 5088751
SGTC_251 melphalan 456.522 µM 0.0110101144687592 0.495818406022127 no 1659 0.495607688567782 2350 460612 A DNA alkylator.
SGTC_861 0443-0273 110 µM 0.0109433567384723 0.495846955974115 no 1660 0.495634319444524 2331 6149169
SGTC_3259 9138485 49.47 µM 0.010545269303293 0.496017204516991 no 1661 0.49579312418617 2385 17646153
SGTC_2391 6285546 200 µM 0.00900201387783693 0.496677209284694 no 1662 0.496408764558814 2389 846083
SGTC_108 0509-0257 621.132 µM 0.00875421059345969 0.496783188325467 no 1663 0.496507619869913 2384 536624
SGTC_2783 7738165 71.43 µM 0.00858555922129251 0.496855316275578 no 1664 0.49657489950419 2374 17201110
SGTC_3114 9122766 49.47 µM 0.00715886414228682 0.497465481756382 no 1665 0.497144050808263 2370 17176985
SGTC_789 1309-1135 70.6 µM 0.00603857114260582 0.497944610168658 no 1666 0.497590973298607 2391 3092424
SGTC_3135 9127742 49.47 µM 0.00563947604115085 0.49811529644882 no 1667 0.497750186493276 2378 3643468
SGTC_1040 k898-0338 155 µM 0.00562187042550696 0.498122826083475 no 1668 0.497757210006389 2394 20969351
SGTC_1091 telmisartan 47.6 µM 0.00531282283310134 0.49825500080453 no 1669 0.497880500314462 2377 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2475 5812728 15.03 µM 0.00523382916582304 0.498288785166136 no 1670 0.497912013790049 2395 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1771 st048882 4.1505 µM 0.00461299814622285 0.49855430533517 no 1671 0.498159686526963 2392 4580403
SGTC_1288 0973-0013 65.5 µM 0.00324052777516971 0.499141292550425 no 1672 0.498707218722257 2396 4315430
SGTC_2996 9066192 71.4286 µM 0.00234144104029311 0.499525821004947 no 1673 0.499065901025469 2399 6472854
SGTC_1378 2093-0007 380 nM 0.00219266268669813 0.499589451748195 no 1674 0.499125254848546 2401 3618014
SGTC_1030 k029-0042 36.7 µM 0.00190498549458228 0.499712487911063 no 1675 0.499240021202316 2393 6080581
SGTC_527 4476-4215 268 µM 0.001881058545716 0.49972272118801 no 1676 0.499249566656757 2389 4418754
SGTC_2865 9030313 51.95 µM 0.00123273886648445 0.5 no 1677 0.499508208470023 2402 42562754
SGTC_1666 st014829 29 µM 0.00112685486604555 0.499954714636788 no 1678 0.499550450045198 2401 3858230
SGTC_2483 5729050 27.16 µM 0.000304422655783443 0.499602969950576 no 1679 0.499878552933372 2405 2865180
SGTC_756 0508-1999 28.3 µM 8.47558915966048e-05 0.499509021072578 no 1680 0.499966187291369 2404 6753853
SGTC_1983 st071813 46.9 µM -0.00281661700325427 0.498268142731671 no 1681 0.49887633387544 2415 11838595
SGTC_2405 ticlatone 3.52 µM -0.00330802298488359 0.498057976302801 no 1682 0.498680292173721 2409 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1090 efavirenz 20.7 µM -0.00443216169375639 0.497577202391559 no 1683 0.498231829095795 2412 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_841 0251-0215 91.2 µM -0.00467239144950864 0.497474460877488 no 1684 0.498135992282475 2429 3888614
SGTC_2256 7954252 200 µM -0.00489558089019843 0.497379007319024 no 1685 0.498046953597128 2428 2972920
SGTC_987 1497-1013 404 µM -0.00534683042095293 0.497186017589049 no 1686 0.497866933442513 2411 1676435
SGTC_428 3448-4153 16.5 µM -0.00590240348761796 0.49694841183327 no 1687 0.497645295365152 2414 3834874
SGTC_1904 st060225 78 µM -0.00705672105957782 0.496454740453453 no 1688 0.497184798973262 2416 66595
SGTC_2384 9036245 200 µM -0.00714562049214604 0.49641672071102 no 1689 0.497149334125116 2460 6462766
SGTC_1334 1486-0610 236 µM -0.00740472694833226 0.496305908483939 no 1690 0.497045968340424 2461 3742339
SGTC_1128 3448-9350 235 µM -0.00749301119398716 0.496268151967703 no 1691 0.497010748999248 2427 619386
SGTC_2399 5884133 200 µM -0.00766041002816349 0.496196560613822 no 1692 0.496943968443531 2426 722445
SGTC_1729 st035615 45.989 µM -0.0080410870352639 0.496033757177827 no 1693 0.496792104971207 2462 17385451
SGTC_1685 st024049 53.0905 µM -0.00977814538126703 0.495290881420256 no 1694 0.496099146545082 2449 1941139
SGTC_2875 9039966 71.43 µM -0.0103431908579267 0.495049235714971 no 1695 0.495873737425003 2478 6463691
SGTC_2736 butenafine 14.65 µM -0.0114265216362928 0.494585946780736 no 1696 0.49544157659697 2438 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3110 9122132 49.47 µM -0.0119033570417646 0.494382029284823 no 1697 0.495251359736658 2491 918317
SGTC_2891 9063876 19.48 µM -0.0123714357279983 0.494181858005974 no 1698 0.495064637114028 2432 6472478
SGTC_3091 9116372 49.47 µM -0.0124772203602801 0.49413661999024 no 1699 0.495022438408718 2505 17169793
SGTC_497 capsazepine 133 µM -0.0125947491401579 0.494086359765084 no 1700 0.494975554893326 2429 2733484 A calcium channel blocker.
SGTC_639 0833-0042 114 µM -0.0135678808558863 0.493670211596279 no 1701 0.494587364737964 2442 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1480 1070-0044 41.2 µM -0.0140500608685005 0.493464015590309 no 1702 0.494395021085688 2484 3124987
SGTC_2555 cholic acid 100 µM -0.0150814769885497 0.49302295412364 no 1703 0.493983589252286 2515 6708657 Influences liver metabolism.
SGTC_1381 2324-0066 62.1 µM -0.0162400761265934 0.492527515952559 no 1704 0.493521431773758 2464 10885928
SGTC_199 4063-0024 41.6 µM -0.0163421435346955 0.492483870604357 no 1705 0.493480718172291 2491 306215
SGTC_3352 9151559 45.5865 µM -0.0173716620623409 0.492043640241834 no 1706 0.493070058071031 2450 17159339
SGTC_2345 9052315 157.45 µM -0.0182443012946676 0.491670500288576 no 1707 0.492721980593035 2452 6469265
SGTC_2076 5212012 200 µM -0.0187773309695788 0.491442580720423 no 1708 0.492509368950365 2437 604802
SGTC_738 1315-0003 72.4 µM -0.0188007756810463 0.491432555997855 no 1709 0.492500017514516 2458 6251474
SGTC_37 0566-0070 1.56 µM -0.0188430470735131 0.491414481189729 no 1710 0.492483156655676 2466 1626686
SGTC_1787 fluconazole 80 µM -0.0196062778058867 0.491088134729181 no 1711 0.492178727915967 2459 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_909 3448-9333 149 µM -0.0203749383077117 0.490759472607254 no 1712 0.491872138016585 2448 3344074
SGTC_1516 st013856 110 µM -0.0212751004364732 0.490374591308194 no 1713 0.491513103158143 2539 5281404 A mutagen and neurotoxin.
SGTC_985 1493-0307 8.71 µM -0.0236966041656605 0.489339277192064 no 1714 0.49054730736491 2456 3278274
SGTC_2102 5377816 72.7585 µM -0.0240486027579249 0.489188785979395 no 1715 0.49040692025363 2469 1379702
SGTC_2280 7785178 200 µM -0.0250187785055461 0.488774011316532 no 1716 0.490019992607436 2452 2954328
SGTC_387 norethindrone acetate 66.7 µM -0.0250309119136016 0.48876882405373 no 1717 0.490015153593393 2473 541197
SGTC_344 k064-0035 6.43 µM -0.0255413864881018 0.488550588192736 no 1718 0.489811568800143 2450 5088750
SGTC_2222 6885208 172.143 µM -0.0256293754623252 0.488512971875244 no 1719 0.489776477765509 2448 609514
SGTC_641 4092-0595 30 µM -0.0258674363516733 0.48841119856875 no 1720 0.489681536688916 2471 786260
SGTC_3063 1327-0034 4 µM -0.0259855856770211 0.488360688882221 no 1721 0.489634417766615 2444 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3039 9090270 49.47 µM -0.0263907599109758 0.488187475405262 no 1722 0.489472832053756 2453 17173750
SGTC_3325 9138760 55.175 µM -0.0264477935621918 0.488163093487497 no 1723 0.489450086858094 2466 43844959
SGTC_473 2-arachidonoylglycerol 10 µM -0.0271556919538934 0.487860470240522 no 1724 0.489167777679577 2439 5282280 An endocannabinoid.
SGTC_1613 st002381 52.1 µM -0.0283060108062336 0.487368729302988 no 1725 0.48870904329603 2463 551167
SGTC_3336 9143619 71.43 µM -0.0289967992607538 0.487073438653047 no 1726 0.488433571671134 2453 45595730
SGTC_2329 6138490 200 µM -0.0302432996053637 0.486540616438607 no 1727 0.487936508109827 2599 720019
SGTC_1559 coumarin 343 70.1 µM -0.0302555459294164 0.486535381809585 no 1728 0.487931624768091 2487 108770 A hepatotoxic, DNA x-linker.
SGTC_2963 9082507 9 µM -0.0306332789308659 0.486373922900227 no 1729 0.487781000923959 2518 16459611
SGTC_1900 st060200 72.8 µM -0.0314023787553281 0.486045184347058 no 1730 0.48747432205792 2450 688945
SGTC_754 3474-0146 171 µM -0.0342939046081561 0.484809337806939 no 1731 0.486321392715219 2463 24762078
SGTC_550 4123-0385 25.7 µM -0.0343919344297961 0.484767442066812 no 1732 0.486282307530679 2488 5731123
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.0345806869945746 0.484686773941503 no 1733 0.486207050917032 2463 16725076
SGTC_2297 7971671 152.32 µM -0.0358338331479385 0.484151226667709 no 1734 0.485707427715841 2501 909016
SGTC_3033 9090887 49.47 µM -0.0358877203597699 0.484128197945532 no 1735 0.485685943647319 2462 19325384
SGTC_2343 7990716 14.84 µM -0.0368936632564754 0.483698317635905 no 1736 0.485284896149069 2477 6456862
SGTC_2081 5214970 32.255 µM -0.0375724479563257 0.483408256004885 no 1737 0.485014287875407 2474 2063512
SGTC_1703 st026983 48.3 µM -0.0379254000542993 0.483257434231174 no 1738 0.484873580649602 2482 1104023
SGTC_2474 5321570 43.32 µM -0.0379275875267394 0.483256499498538 no 1739 0.484872708601769 2583 2841384
SGTC_247 mechlorethamine 29.705 µM -0.0384981608187669 0.483012689995042 no 1740 0.484645248926245 2467 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2010 4012422 159 µM -0.0394320829695083 0.482613633022093 no 1741 0.484272950641189 2511 952393
SGTC_1283 0922-0125 16.4 µM -0.0401640310163681 0.482300890016449 no 1742 0.483981176784435 2514 3360884
SGTC_120 rhodamine 6G 52.259 µM -0.0405931321643948 0.482117550931285 no 1743 0.483810129692225 2486 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_345 1362-0200 395 µM -0.0406250347441279 0.482103920286841 no 1744 0.483797412894261 2502 1419823
SGTC_1481 3346-2004 36 µM -0.0435916306948009 0.480836510865632 no 1745 0.482614961547863 2484 2770522
SGTC_979 1426-2828 121 µM -0.044483161207809 0.480455662366016 no 1746 0.482259637049828 2551 747872
SGTC_943 3253-1379 105 µM -0.0454983757215619 0.480021999654326 no 1747 0.481855034773006 2528 668464
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0462808502008582 0.479687771128023 no 1748 0.4815432011392 2496 3256 An antibiotic and ribosome inhibitor.
SGTC_2840 9008771 71.43 µM -0.0467159047054499 0.479501946787644 no 1749 0.481369827031751 2573 2992978
SGTC_1849 st056239 19.2 µM -0.0475832090774126 0.479131509381694 no 1750 0.481024207042775 2498 5393181
SGTC_688 0527-0193 473 µM -0.0493373494000118 0.478382347795564 no 1751 0.480325227615065 2531 4007154
SGTC_1048 3161-0300 24.5 µM -0.0505278929589172 0.477873931534572 no 1752 0.479850861210467 2502 2165101
SGTC_3271 9137798 49.47 µM -0.0506669143242614 0.477814565418992 no 1753 0.479795470657996 2499 6498326
SGTC_3300 9124615 50.48 µM -0.0511020518280425 0.477628752395998 no 1754 0.47962210050432 2573 24824903
SGTC_319 1348-1596 45.5 µM -0.0523841926619599 0.477081279259036 no 1755 0.479111284625716 2597 5380505
SGTC_2879 9041815 71.43 µM -0.0525507948240301 0.477010143419038 no 1756 0.479044911399605 2493 4942971
SGTC_512 prima-1 270 µM -0.053844271675617 0.476457879389942 no 1757 0.478529618480453 2608 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1346 1488-2224 62.4 µM -0.0543313143160063 0.476249942891389 no 1758 0.478335600587063 2477 3722427
SGTC_560 2332-1943 155 µM -0.0546666982326597 0.476106758862177 no 1759 0.478202000316431 2492 21177716
SGTC_1722 st034304 3.6505 µM -0.0547951710921182 0.476051911306905 no 1760 0.478150823767415 2511 4036148 YLR033W RSC58
SGTC_56 0957-0365 83.25 µM -0.0554736931316122 0.475762244640123 no 1761 0.477880543754548 2494 6752360
SGTC_1180 1193-0155 285 µM -0.0559063033839402 0.475577566425061 no 1762 0.477708224655741 2561 2921347
SGTC_1305 1181-0477 144 µM -0.0566494525096525 0.475260333660934 no 1763 0.477412220179627 2548 6252086
SGTC_1643 st009866 20.2 µM -0.0569421226131899 0.475135404017297 no 1764 0.477295649867247 2510 3156273 YOR207C RET1
SGTC_2259 7964009 200 µM -0.0583114748560541 0.474550912734417 no 1765 0.476750263727796 2648 313134
SGTC_1260 0700-1617 7.75 µM -0.0584371369037425 0.47449727814857 no 1766 0.476700217164968 2546 2853078
SGTC_1366 1683-0113 21.9 µM -0.0605903704285382 0.473578316025438 no 1767 0.475842721359729 2521 708623
SGTC_1445 4239-0156 97.7 µM -0.0606586256679024 0.473549188165214 no 1768 0.475815541452376 2632 4008346
SGTC_143 4032-1194 15.74 µM -0.0607457804829499 0.473511995134158 no 1769 0.47578083571178 2491 1806963
SGTC_2511 berberine 10.47 µM -0.0608417281032124 0.47347105006939 no 1770 0.475742628818701 2532 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2266 7929956 200 µM -0.0616984511677843 0.473105461174591 no 1771 0.47540148670521 2506 2967153
SGTC_1116 jasmonic acid 1.58368 µM -0.0623726325227938 0.472817784100463 no 1772 0.475133044298407 2611 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_393 acivicin 6.25 µM -0.0635953618681771 0.472296074711051 no 1773 0.474646212480595 2539 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1426 4048-4480 71.7 µM -0.063977855040103 0.472132883732923 no 1774 0.474493929897077 2526 14224343
SGTC_2105 5350118 200 µM -0.0640245367915949 0.472112967250908 no 1775 0.474475344675647 2542 2133313
SGTC_439 amiodarone 34.4 µM -0.0648115704587368 0.471777194717463 no 1776 0.47416201446364 2616 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_449 xestospongin c 11.1929 µM -0.0676268856350419 0.470576261395312 no 1777 0.473041326372893 2587 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2630 antimycin a 100 µM -0.0686565370454213 0.470137107654438 no 1778 0.472631507469192 2509 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3041 9091929 49.47 µM -0.0690855141434885 0.469954156520313 no 1779 0.472460775758154 2592 25236887
SGTC_3069 9117009 49.47 µM -0.0696835902991625 0.469699098227311 no 1780 0.472222751536443 2525 41904981
SGTC_2310 7668677 200 µM -0.0720923594829818 0.468671970440385 no 1781 0.471264203327288 2600 2197143
SGTC_1266 0828-0227 32.9 µM -0.0727835385009814 0.468377281693371 no 1782 0.470989185291584 2607 3913820
SGTC_2508 celastrol 40.54 µM -0.0732150796499017 0.468193300045235 no 1783 0.470817483383971 2512 122724 Celastrol is a natural product and antioxidant.
SGTC_1515 3460-0031 42.1 µM -0.0735928327879574 0.46803225575214 no 1784 0.470667187141112 2553 2876596
SGTC_1635 st007035 42.4 µM -0.073686630225799 0.467992268695359 no 1785 0.470629868700087 2526 3716403
SGTC_2716 st080858 38.6235 µM -0.0751572678828318 0.467365359389817 no 1786 0.470044791719138 2564 5296050
SGTC_2361 9034121 116 µM -0.0757987717509984 0.467091921815967 no 1787 0.469789596658115 2578 6496917
SGTC_1446 4239-0190 62 µM -0.0763248376553192 0.466867700636558 no 1788 0.469580332942339 2557 1340085
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0769269240682345 0.466611090704976 no 1789 0.469340839348837 2548 688798
SGTC_2221 6807166 181.081 µM -0.0778813205402249 0.466204354293313 no 1790 0.468961229161199 2559 674925
SGTC_1861 st057647 17.4 µM -0.0785513514668377 0.465918827385814 no 1791 0.468694741905609 2697 688668
SGTC_869 0564-0080 44.1 µM -0.0787748621684882 0.465823584453934 no 1792 0.468605849490675 2596 6843321
SGTC_2814 7977482 42.97 µM -0.0788485144955912 0.465792199971039 no 1793 0.468576557574934 2618 6456762
SGTC_1214 0358-0031 63.7 µM -0.0795351481414772 0.465499624204772 no 1794 0.468303487988616 2778 4301366
SGTC_748 act1.228 77.9 µM -0.0804196039053329 0.465122783599503 no 1795 0.467951767869274 2544 4421505 YNR035C ARC35
SGTC_1848 st056003 16.4 µM -0.0808289141675882 0.464948399093058 no 1796 0.467789006557905 2526 146492
SGTC_2387 9077560 195.08 µM -0.0814463253406491 0.464685367023171 no 1797 0.467543504580156 2527 5303272
SGTC_1604 st002052 72.4 µM -0.0815364916592151 0.464646955282607 no 1798 0.46750765266487 2677 6254834 YHR062C RPP1
SGTC_572 0960-0087 17.7 µM -0.0818170411608821 0.464527440538235 no 1799 0.467396102309973 2540 6796365
SGTC_1186 1319-0216 26 µM -0.0818732188098686 0.464503509112517 no 1800 0.467373765608604 2667 4565136
SGTC_2212 7123476 200 µM -0.0823023271127749 0.464320715148855 no 1801 0.467203151966153 2565 1085715
SGTC_729 4092-0585 94.1 µM -0.0823065953181723 0.464318896992521 no 1802 0.467201454956097 2556 2169061
SGTC_2877 9040724 71.43 µM -0.082514192592451 0.464230466277032 no 1803 0.467118916381906 2561 6463895
SGTC_2799 7812892 81.82 µM -0.0831916043901861 0.463941919839887 no 1804 0.466849594162924 2597 20205235
SGTC_2166 5933061 31.504 µM -0.0832406070260548 0.463921047692429 no 1805 0.466830112510983 2889 2877375
SGTC_2919 7978188 46.38 µM -0.0838081116664859 0.463679332422972 no 1806 0.466604499267686 2572 2980291
SGTC_1928 4'-methoxychalcone 40.3 µM -0.0842812394037005 0.46347782502233 no 1807 0.466416414056081 2697 641818
SGTC_1847 st056231 15 µM -0.0843042917882254 0.463468007138796 no 1808 0.466407250099324 2553 5393180
SGTC_3307 9126885 69.2785 µM -0.0843782320585731 0.463436516535282 no 1809 0.466377856928803 2554 24824909
SGTC_1614 st002383 48.6 µM -0.0848695640784323 0.463227267762053 no 1810 0.46618254440427 2558 1947235
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.0869894407748958 0.462324570781513 no 1811 0.465339952665397 2557 17037758
SGTC_3297 9117502 71.43 µM -0.0872806567045895 0.462200578744076 no 1812 0.465224214525645 2543 7453720
SGTC_765 1319-0117 244 µM -0.087652233993179 0.462042376301455 no 1813 0.465076542590528 2569 3487746 YGL099W LSG1
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0878924784315995 0.46194009322064 no 1814 0.464981067405642 2602 279621
SGTC_2263 7948595 193.29 µM -0.0879146211100643 0.461930666193005 no 1815 0.464972267818117 2561 2971371
SGTC_3330 9141424 71.43 µM -0.0879186385518144 0.461928955808974 no 1816 0.464970671272798 2647 27261020
SGTC_1699 st031318 29.054 µM -0.0882086560746474 0.461805485727642 no 1817 0.464855418792226 2638 5340658
SGTC_2147 5545932 89.7195 µM -0.0883781788620056 0.461733315956691 no 1818 0.464788052083619 2580 797404
SGTC_2378 9074213 121.43 µM -0.0889277178737127 0.461499373165651 no 1819 0.464569677568527 2571 657714
SGTC_1741 st038134 10.228 µM -0.0896604628938999 0.461187458969131 no 1820 0.464278517694724 2665 1272587
SGTC_2823 7987624 58.44 µM -0.0917942611463633 0.460279282462282 no 1821 0.463430751876996 2660 2239440
SGTC_2581 avocatin a 64 µM -0.0931581269645873 0.459698908964178 no 1822 0.462888969757782 2614 6710728 A skin care supplement.
SGTC_2137 5261020 140 µM -0.0934065218245137 0.459593217308389 no 1823 0.462790304752679 2572 763655
SGTC_2141 5621638 7.665 µM -0.0949139626270471 0.458951864930988 no 1824 0.462191583008333 2686 2856238
SGTC_2566 crystal violet carbinol 226 nM -0.095611804950961 0.45865499857582 no 1825 0.46191444458116 2732 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_360 0957-0399 1.01 µM -0.0957230922452214 0.458607658413642 no 1826 0.461870250077486 2673 6752301 YPR165W RHO1
SGTC_2800 7887935 81.82 µM -0.0960382611436552 0.458473592866333 no 1827 0.461745092496499 2668 2961002
SGTC_2306 7482397 179.52 µM -0.0966129274966859 0.458229155283274 no 1828 0.461516894933101 2646 891448
SGTC_840 0245-0196 390 µM -0.0978241593362214 0.457714002814744 no 1829 0.461035961506839 2692 3827528
SGTC_3058 9093861 49.47 µM -0.0992326979880867 0.457115022612288 no 1830 0.460476756867032 2676 17217477
SGTC_3076 9116187 49.47 µM -0.0998193048213936 0.456865597067888 no 1831 0.460243890782089 2659 27241210
SGTC_3331 9141060 1.957 µM -0.100547931583143 0.456555808244879 no 1832 0.459954665854807 2595 4906567 YPR165W RHO1
SGTC_201 4262-0159 12.803 µM -0.101248223344779 0.456258091439245 no 1833 0.459676708337633 2669 1341029
SGTC_511 blebbistatin 171 µM -0.101540956115541 0.456133648484967 no 1834 0.459560523636087 2727 3476986 A myosin inhibitor.
SGTC_2928 9011484 9.79 µM -0.101927398883924 0.455969375280704 no 1835 0.459407151026171 2675 2994751
SGTC_1224 0823-0416 294 µM -0.102364238009518 0.455783688120808 no 1836 0.459233784228376 2686 3598164
SGTC_931 2812-0076 566 µM -0.104899602587581 0.454706172931586 no 1837 0.458227737159367 2575 3450959
SGTC_2429 5902844 64.44 µM -0.105683878436431 0.454372927366958 no 1838 0.457916585926708 2717 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1571 st070080 73.4 µM -0.106808574277295 0.453895090521629 no 1839 0.457470422550735 2702 4315245
SGTC_2140 5586273 200 µM -0.107650863691058 0.453537280173373 no 1840 0.457136324001098 2587 854421
SGTC_207 4185-0010 4.486 µM -0.108278094482088 0.453270852692858 no 1841 0.456887549256492 2595 3761753
SGTC_911 3456-4043 236 µM -0.108689103410308 0.453096280709097 no 1842 0.456724542434663 2682 914281
SGTC_740 k014-0057 261 µM -0.109331915656938 0.452823270741436 no 1843 0.45646961664296 2709 4012779
SGTC_624 k048-0052 28 µM -0.110020946811415 0.452530655822333 no 1844 0.456196381303153 2657 6835531
SGTC_906 1165-0455 526 µM -0.110215421705492 0.452448071681476 no 1845 0.456119266016343 2591 3252859
SGTC_2047 4141938 200 µM -0.110308013593071 0.452408753079534 no 1846 0.456082551061025 2620 3807862
SGTC_2176 5809774 33.9695 µM -0.110785496167264 0.452206000322424 no 1847 0.455893223464353 2693 2870539
SGTC_127 0180-0333 59.125 µM -0.111603140970132 0.451858833927719 no 1848 0.455569040725042 2591 771601
SGTC_2162 5663267 200 µM -0.111764788070538 0.45179020402337 no 1849 0.455504953799188 2610 6456493
SGTC_2059 5238311 157 µM -0.111879184032529 0.451741636228437 no 1850 0.455459600851684 2617 703021
SGTC_2319 6033012 152.6 µM -0.112039389366419 0.451673620882701 no 1851 0.455396087486819 2639 847246
SGTC_1153 4055-0057 267 µM -0.112543372295345 0.451459663651169 no 1852 0.45519629102138 2602 882706
SGTC_885 0865-0106 16.8 µM -0.114930546339143 0.450446422821211 no 1853 0.45425008651921 2606 2793380
SGTC_3107 9121808 49.47 µM -0.115470659644393 0.450217215197685 no 1854 0.454036037552035 2602 662681
SGTC_1465 k213-0056 144 µM -0.115842568802869 0.450059397935377 no 1855 0.453888656288045 2606 24048857 YMR208W ERG12
SGTC_671 0560-0003 407 µM -0.116650825956207 0.449716446469168 no 1856 0.453568379668139 2704 3238678
SGTC_1985 st071382 65.5 µM -0.116785128654012 0.449659464144069 no 1857 0.453515164359349 2614 6123237
SGTC_860 0443-0016 25.1 µM -0.117037101968115 0.449552559001586 no 1858 0.453415326192334 2628 5337942
SGTC_800 3448-7362 155 µM -0.117511131306181 0.449351451705184 no 1859 0.453227511825835 2609 15991913
SGTC_462 ag-879 158 µM -0.118413079301797 0.448968835571772 no 1860 0.452870181452947 2688 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1005 4092-0690 4.4 µM -0.119055825235964 0.448696204702799 no 1861 0.45261556405068 2665 1529343
SGTC_3262 9137218 49.47 µM -0.119625594267977 0.448454548393759 no 1862 0.452389872008981 2579 17650664
SGTC_483 fpl-64176 144 µM -0.119727950303504 0.448411138121803 no 1863 0.452349329238371 2625 3423
SGTC_1659 st012954 42.1 µM -0.119885690368251 0.44834424010981 no 1864 0.452286850073 2732 24207262
SGTC_2438 5259590 200 µM -0.120476374757051 0.448093742237942 no 1865 0.452052896764802 2727 1201127
SGTC_2829 7992743 58.44 µM -0.120643440953989 0.448022896432155 no 1866 0.451986729606434 2726 16462845
SGTC_937 3122-0005 46.7 µM -0.12081118975213 0.447951762831721 no 1867 0.451920293443246 2712 759535
SGTC_82 0054-0107 293.755 µM -0.122583634724065 0.447200263183287 no 1868 0.451218407146658 2709 3104697
SGTC_2025 5147754 141 µM -0.122809572635808 0.447104481241755 no 1869 0.451128946889627 2702 315777 YLR208W SEC13
SGTC_2849 9019321 12.99 µM -0.123779606988975 0.446693289349261 no 1870 0.450744889445011 2724 16489627
SGTC_3197 9113331 49.47 µM -0.124286453246835 0.446478462948674 no 1871 0.450544236438864 2759 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1521 st012942 49.4 µM -0.124584934951446 0.446351959049924 no 1872 0.450426077816152 2876 24207259
SGTC_1917 st066507 28.5 µM -0.125681259737613 0.445887356554835 no 1873 0.449992118393808 2626 3156428
SGTC_2608 thymoquinone 42.66 µM -0.125751086054909 0.445857767941996 no 1874 0.449964480987231 2599 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2088 5278280 127.392 µM -0.126579791961611 0.445506630314812 no 1875 0.449636495974274 2688 791502
SGTC_3312 9133330 71.43 µM -0.126613225466139 0.445492464831588 no 1876 0.449623264390847 2780 17617324
SGTC_1140 3229-1848 2.98 µM -0.126862128989753 0.445387008775952 no 1877 0.449524760543098 2719 2849525
SGTC_2722 naftopidil 47.16 µM -0.127190973168819 0.445247689193594 no 1878 0.449394624861765 2623 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3073 9114972 49.47 µM -0.129159545412142 0.444413817143497 no 1879 0.448615703051561 2687 41905075
SGTC_307 1501-1223 22.3 µM -0.129972888177129 0.444069363006248 no 1880 0.448293938406198 2682 2830329
SGTC_1513 0337-0559 19 µM -0.130171366166607 0.44398531313174 no 1881 0.448215424143729 2656 775073
SGTC_1259 0671-0132 43 µM -0.130331792894446 0.443917378742714 no 1882 0.448151963746686 2671 X1259
SGTC_1010 4112-3296 15.2 µM -0.130808353566815 0.443715583828536 no 1883 0.447963457295579 2745 704384
SGTC_1943 st076331 65.2 µM -0.130875682617159 0.443687075181888 no 1884 0.447936825829614 2631 24208415
SGTC_1073 triclabendazole 3.09 µM -0.130982982998114 0.443641642369861 no 1885 0.447894384509391 2690 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2390 9097792 176.6 µM -0.131161467646772 0.443566070565591 no 1886 0.447823788466236 2648 4497149
SGTC_2014 4013930 200 µM -0.131319467642615 0.443499173836949 no 1887 0.447761296097922 2636 64556
SGTC_2322 7413319 38.22 µM -0.131505736753654 0.443420310117207 no 1888 0.447687624357059 2746 1840400
SGTC_1052 3253-3998 198 µM -0.131709006992245 0.443334250916624 no 1889 0.447607230518913 2628 5450317
SGTC_386 1509-0011 3.07 µM -0.131840794566517 0.443278456998559 no 1890 0.447555109385704 2634 3107280
SGTC_2782 7736369 71.43 µM -0.132211486841659 0.44312152582079 no 1891 0.447408507847544 2682 2950836 YOL077C BRX1
SGTC_350 k064-0020 19.8 µM -0.1327996631291 0.4428725419243 no 1892 0.447175910392084 2765 2790705
SGTC_3217 9129673 49.47 µM -0.134057812789136 0.442340024050128 no 1893 0.446678429481696 2782 17248312
SGTC_1272 0839-0021 27 µM -0.135071946576106 0.441910862840221 no 1894 0.446277495136361 2724 5027250
SGTC_2765 myclobutanil 7.74 µM -0.135623762073418 0.441677374126475 no 1895 0.446059359799837 2739 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1024 4507-0395 26 µM -0.135860158299276 0.441577354405799 no 1896 0.445965916218597 2818 4201836
SGTC_1718 roemerine 11.9335 µM -0.136298782662197 0.441391781425435 no 1897 0.445792543099601 2703 235224 An aporphine alkaloid with mutagenic activity.
SGTC_864 0469-0573 172 µM -0.13632971499381 0.441378695074916 no 1898 0.44578031700405 2639 689425
SGTC_2753 fluvastatin 17.09 µM -0.136406578138399 0.441346177336113 no 1899 0.445749936842088 2714 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3006 9075424 71.4286 µM -0.137109241045784 0.441048926968025 no 1900 0.44547222407861 2654 7465181
SGTC_2492 derrusnin 100 µM -0.137219076558195 0.441002465798153 no 1901 0.445428816312487 2620 1715307 Part of coumarin class of compounds.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.138640929584974 0.440401085804201 no 1902 0.444866949243641 2649 368090
SGTC_1398 3558-0053 112 µM -0.138779425522224 0.440342515564667 no 1903 0.444812226347383 2658 4532369
SGTC_67 0335-0847 266 µM -0.13883373978975 0.440319546296528 no 1904 0.444790765831438 3038 4552207 YOR254C SEC63
SGTC_1851 st056236 18.9 µM -0.139307896352829 0.440119036080368 no 1905 0.444603425169636 2655 5393171
SGTC_710 3448-4187 58 µM -0.139820391597794 0.439902330562459 no 1906 0.444400950697762 2671 3946412
SGTC_1831 st055328 12 µM -0.140869127294084 0.439458935194582 no 1907 0.44398666587499 2710 1103068
SGTC_638 3970-0837 4.09 µM -0.143169351461735 0.438486689230785 no 1908 0.443078217210936 2697 4118451 YLR208W SEC13
SGTC_1827 berberine 7.24 µM -0.143245561455399 0.43845448353346 no 1909 0.443048123991355 2664 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1163 k060-0048 49.9 µM -0.144270970761472 0.438021193970102 no 1910 0.442643250221475 2662 6809982
SGTC_2174 5790901 200 µM -0.144631839770532 0.437868725410689 no 1911 0.442500778519987 2744 786020
SGTC_3225 9130819 49.47 µM -0.144752525450318 0.437817737298777 no 1912 0.442453133265678 2678 4547121
SGTC_2337 9009472 200 µM -0.145343490692839 0.437568077180116 no 1913 0.442219839327765 2751 5742383
SGTC_673 1082-0474 110 µM -0.145526227556941 0.437490882899339 no 1914 0.442147704784386 2680 3098046
SGTC_872 0588-0139 234 µM -0.145895433211189 0.437334925107794 no 1915 0.442001968392379 2674 2047100
SGTC_31 0508-1974 57.237 µM -0.145973444481129 0.43730197326776 no 1916 0.44197117604064 2696 6810525
SGTC_2313 7726885 200 µM -0.146256873941308 0.437182256763265 no 1917 0.441859304649496 2762 726423
SGTC_2023 5144124 124 µM -0.146712850345347 0.436989670999494 no 1918 0.441679337629196 2697 2830192
SGTC_574 1315-0397 40 µM -0.148628832983647 0.436180602084768 no 1919 0.440923260135743 2665 6794277
SGTC_1525 8-methoxypsoralen 92.5 µM -0.149188834895002 0.43594417831962 no 1920 0.440702314930552 2848 4114 Related to psoralen; DNA damaging agent.
SGTC_2760 etidronate 98.04 µM -0.150858229032786 0.435239523207039 no 1921 0.440043775847501 2712 3305 A chelator and antioxidant.
SGTC_299 1273-0059 1.44 µM -0.152105889881946 0.434713016813416 no 1922 0.439551709405166 2762 2848077
SGTC_1648 st011736 69.8 µM -0.152364361668228 0.43460395750685 no 1923 0.439449782061615 2820 2855514
SGTC_2998 9066762 71.4286 µM -0.153559843179479 0.434099602188457 no 1924 0.438978400899683 2817 4945196
SGTC_2115 tiliquinol 12.7705 µM -0.153638393959833 0.434066466565124 no 1925 0.438947431165185 2800 71208 A bioactive hydroxyquinoline.
SGTC_369 0957-0393 4.5 µM -0.153803004419791 0.433997029290092 no 1926 0.438882532421036 2726 6997992
SGTC_3054 9094397 49.47 µM -0.153873227472096 0.433967407871118 no 1927 0.438854847025943 2717 2598354
SGTC_2486 5283202 22.39 µM -0.154710823169835 0.433614122710579 no 1928 0.438524648539787 2745 1377751
SGTC_2484 5809818 12.04 µM -0.155453627460907 0.433300863487055 no 1929 0.438231854682574 2744 2870548
SGTC_3234 9132280 49.47 µM -0.155568889537646 0.433252258325149 no 1930 0.438186424438412 2749 17612295
SGTC_426 0988-0037 14.6 µM -0.155856398661284 0.433131022264159 no 1931 0.438073107025611 2649 5383008
SGTC_2965 9082772 38.63 µM -0.156043009456868 0.4330523361013 no 1932 0.437999559893701 2778 16459634
SGTC_349 k015-0014 24 µM -0.156609502800029 0.432813485229882 no 1933 0.43777630640776 2678 2196908
SGTC_685 1278-0033 54.9 µM -0.1574265563186 0.432469033798387 no 1934 0.43745434273947 2762 3590572
SGTC_1812 st052057 4.327 µM -0.158033241633419 0.432213302065196 no 1935 0.437215302400266 2660 3645418
SGTC_1441 4106-0040 13 µM -0.158658253325641 0.431949875043267 no 1936 0.436969065244302 2673 2904180
SGTC_268 camptothecin 39.6153 µM -0.15882397595254 0.431880032110769 no 1937 0.436903779247875 2681 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3180 9109287 49.47 µM -0.15986410381265 0.431441724379248 no 1938 0.436494062898972 2818 18891271
SGTC_1423 4048-0112 5.59 µM -0.160236891921179 0.431284652758605 no 1939 0.436347234644795 2772 X1423
SGTC_798 1287-0182 476 µM -0.160651226531064 0.431110088565886 no 1940 0.436184052962471 2708 1649755
SGTC_2692 st077426 47.7 µM -0.161380220108374 0.430802987422764 no 1941 0.435896972269809 2804 25238571
SGTC_2134 5324836 1.464 µM -0.162299094108004 0.430415955495434 no 1942 0.435535164010084 2738 699272
SGTC_2268 7933382 153.85 µM -0.162807749653505 0.430201737278116 no 1943 0.435334903171772 2661 935025 YOR257W CDC31
SGTC_1 0258-0098 57.368 µM -0.163881408503014 0.429749637730276 no 1944 0.434912251540025 2763 6790032 YDR047W HEM12
SGTC_753 1322-0200 289 µM -0.163989657896628 0.429704060846505 no 1945 0.434869642697534 2841 5403907
SGTC_2540 epiandrosterone 100 µM -0.164027776700916 0.429688011683416 no 1946 0.43485463865378 2722 441302 A steroid.
SGTC_2178 5812956 200 µM -0.165769630871128 0.428954763069603 no 1947 0.434169123234337 2636 5403383
SGTC_2269 7935389 174.42 µM -0.166377450627065 0.42869895363435 no 1948 0.433929959206536 2668 97605
SGTC_2744 captopril 92.04 µM -0.167535261510666 0.428211755700292 no 1949 0.433474452458151 2762 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2107 5363541 170.161 µM -0.168284997097775 0.42789633103126 no 1950 0.433179538061873 2706 244052
SGTC_2831 7999036 19.48 µM -0.168508559689551 0.42780228390452 no 1951 0.433091605150336 2996 2988270
SGTC_1479 0549-0158 134 µM -0.171243285269456 0.42665218757581 no 1952 0.432016236703522 2751 5440202
SGTC_2606 farnesol 9.78 µM -0.171413910751177 0.426580451121073 no 1953 0.431949158731077 2851 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3125 9127534 49.47 µM -0.17197601291449 0.426344142437306 no 1954 0.431728193471497 2673 1639235
SGTC_2670 beta-carotene 100 µM -0.172294544673112 0.426210242888374 no 1955 0.431602986471362 2746 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1733 st037357 54.9 µM -0.172837137564691 0.425982175512336 no 1956 0.431389722378646 2696 1272339 YGL099W LSG1
SGTC_2820 7989630 71.43 µM -0.17337927165094 0.425754325709473 no 1957 0.431176658591273 2753 2984098
SGTC_708 3448-5400 146 µM -0.173567402828314 0.425675263141789 no 1958 0.431102725949121 2737 3462195
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.17359427538137 0.425663970132285 no 1959 0.431092165648496 2725 77254
SGTC_2415 st077333 57.7 µM -0.175932976427309 0.424681381329744 no 1960 0.430173298979582 2900 2766255
SGTC_1846 st056244 14.8 µM -0.176416541025683 0.424478273229065 no 1961 0.429983355301654 2788 5393182
SGTC_2743 auranofin 4.32 µM -0.178446672028008 0.423625791572129 no 1962 0.429186099234394 2755 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1463 k081-0032 34.1 µM -0.179566164775928 0.423155852814656 no 1963 0.428746584727023 2782 977755
SGTC_1837 st055472 66.5 µM -0.181145716162742 0.422492977492431 no 1964 0.42812660090332 2892 676091
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.181703960757922 0.422258756673365 no 1965 0.42790752874246 2857 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1162 k048-0130 20.1 µM -0.181838229339253 0.422202426151337 no 1966 0.427854840979178 2724 6797406
SGTC_3087 9117406 49.47 µM -0.182221482000169 0.422041646567911 no 1967 0.427704457510847 2856 42546093
SGTC_711 k292-0785 179 µM -0.182722526975168 0.421831471142263 no 1968 0.427507869679957 2713 4146315
SGTC_2142 5622915 118.518 µM -0.182722907439964 0.42183131155556 no 1969 0.427507720409274 2756 5322196
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.184220986450926 0.421203039177809 no 1970 0.426920048211444 2890 688751
SGTC_1311 1190-0148 100 µM -0.184440519452374 0.421110987068173 no 1971 0.426833942553655 2853 1961333
SGTC_214 4373-3496 70 µM -0.18472193333499 0.420992994070826 no 1972 0.42672357095672 2759 3779166
SGTC_156 3474-0145 5.642 µM -0.185157866616301 0.420810227214479 no 1973 0.426552607593569 2664 2265471
SGTC_2064 5220758 200 µM -0.185668314768838 0.420596241380869 no 1974 0.426352438691691 2874 788518
SGTC_2605 digitonin 300 nM -0.185782210942185 0.42054849797272 no 1975 0.426307777639645 2752 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_897 1000-0139 31.4 µM -0.186055283241768 0.420434035304277 no 1976 0.426200704176824 2892 6151020
SGTC_1739 st037196 92.5 µM -0.186403596174274 0.420288044073374 no 1977 0.426064136257703 2863 612214
SGTC_2363 9053361 176 µM -0.186690141933187 0.420167950040362 no 1978 0.42595179290435 2884 6469797 YMR079W SEC14
SGTC_2453 5731132 22.18 µM -0.187393715475302 0.419873107276313 no 1979 0.425675974825467 2860 1362040
SGTC_970 1315-0089 19.5 µM -0.187931897126197 0.419647604744568 no 1980 0.425465018961737 2747 6811083 YLR033W RSC58
SGTC_2217 6934799 96.0675 µM -0.189336862975851 0.419059037037572 no 1981 0.424914402660832 2795 675606
SGTC_3049 9092223 49.47 µM -0.189536046416902 0.418975609820174 no 1982 0.424836353055179 2839 8623917
SGTC_801 0866-0028 10.1 µM -0.189732719506522 0.418893237628496 no 1983 0.424759290016394 2725 6849771
SGTC_1109 tnp00067 928.257 nM -0.19005549991043 0.418758055873677 no 1984 0.42463282018356 2771 676295
SGTC_2430 5571206 200 µM -0.190345081892209 0.418636785916884 no 1985 0.424519364554277 2879 1731771
SGTC_1761 st044296 37 µM -0.19076439443121 0.418461201635099 no 1986 0.424355092739347 2716 1826700
SGTC_342 k048-0088 23.3 µM -0.192081904249125 0.417909609207479 no 1987 0.423839024647157 2710 6820570
SGTC_2693 st077581 40.7 µM -0.193778090078739 0.417199717054242 no 1988 0.42317482170459 2814 25238761
SGTC_2376 9072922 81.32 µM -0.193995539280172 0.417108729108226 no 1989 0.423089687347255 2869 17087968
SGTC_571 k831-0106 44.2 µM -0.197407643168719 0.415681576241708 no 1990 0.421754274462474 2786 4783639
SGTC_1285 0929-0069 65.5 µM -0.197469738392311 0.415655614419583 no 1991 0.421729980216781 2793 1206237
SGTC_1868 st057644 42.7 µM -0.197782579375556 0.41552482216798 no 1992 0.421607588287063 2747 688665
SGTC_2683 piperine 63.03 µM -0.197920747709392 0.415467059864978 no 1993 0.421553535474565 2775 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_311 1315-0136 58 µM -0.198471074384676 0.415237009831376 no 1994 0.421338256939402 2909 6759207
SGTC_784 4579-0127 173 µM -0.198926797960553 0.415046528200961 no 1995 0.421160003339068 2961 1948547
SGTC_1955 wogonin 32.4 µM -0.200240454369351 0.414497562917276 no 1996 0.42064626489834 3012 5281703 A flavanone.
SGTC_850 0388-0143 75.9 µM -0.202938601158487 0.413370556238372 no 1997 0.419591511314433 2777 67273
SGTC_3315 9136395 68.55 µM -0.203186523755532 0.413267035465294 no 1998 0.419494622812673 2800 16876844
SGTC_2739 tacrine 100.86 µM -0.203924661082228 0.412958859889192 no 1999 0.419206186619996 2856 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_707 0865-0008 204 µM -0.204675933646051 0.412645255366535 no 2000 0.418912662252709 2793 723043
SGTC_1138 3761-0006 1.03 µM -0.204824501267263 0.412583245219454 no 2001 0.418854621792542 2748 12061087
SGTC_1929 genistein trimethyl ether 50.5 µM -0.204903925629255 0.412550095443057 no 2002 0.418823594043302 2921 136420
SGTC_3189 9110682 49.47 µM -0.20552369206057 0.41229144161096 no 2003 0.418581494789641 2874 17122418
SGTC_2911 7942208 15.64 µM -0.205642596791958 0.412241822164088 no 2004 0.418535050577775 2861 1243384
SGTC_1225 1216-0074 20.6 µM -0.206490488812513 0.411888033952756 no 2005 0.418203896744167 2798 4241466
SGTC_2092 5303694 80.6725 µM -0.206565852894811 0.41185659128255 no 2006 0.418174465250231 2789 1963699
SGTC_1569 carminic acid 40.6 µM -0.206789393841507 0.411763331030172 no 2007 0.418087169808401 2878 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1546 5-methoxyflavanone 78.7 µM -0.207418927862826 0.411500719137708 no 2008 0.417841350860387 2852 147795
SGTC_2715 st079500 56.4 µM -0.207627195485093 0.411413848432866 no 2009 0.417760034075396 2746 28246688
SGTC_144 4161-2749 112.381 µM -0.207815907893548 0.411335138171969 no 2010 0.417686355537215 2772 797501 YMR168C CEP3
SGTC_1079 idarubicin 2.36 µM -0.208090712788049 0.411220525886639 no 2011 0.417579069281912 2785 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2720 fluspirilene 36.88 µM -0.208276617384155 0.411142995353337 no 2012 0.4175064939659 2865 3396 An atypical antipsychotic.
SGTC_1056 3448-1962 115 µM -0.208596298593544 0.411009682104322 no 2013 0.417381700154971 2877 715507
SGTC_2560 caryophyllene 100 µM -0.20860581760813 0.411005712648573 no 2014 0.41737798434902 2760 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_895 0964-0006 13.7 µM -0.209406467381998 0.410671872106004 no 2015 0.417065472222657 2812 6738897
SGTC_427 1354-0053 47.3 µM -0.209546919571302 0.410613315542188 no 2016 0.417010655880467 3010 6813657
SGTC_2398 5228213 48.84 µM -0.212663869478717 0.409314328720324 no 2017 0.41579457503497 2947 80771 YMR134W ERG29
SGTC_402 epigallocatechin gallate 10 µM -0.21281160947313 0.409252782764374 no 2018 0.415736954055556 2804 65064 An antioxidant.
SGTC_19 0279-0214 38.434 µM -0.213161849242933 0.409106887803293 no 2019 0.415600362139598 2763 3566274 YBR002C RER2
SGTC_1032 k061-1018 98.7 µM -0.213653310805992 0.408902187094997 no 2020 0.415408711564465 2984 4005393
SGTC_190 3970-0790 3.722 µM -0.213801074357848 0.408840646336183 no 2021 0.415351093555003 2788 2832352
SGTC_118 0083-0097 135.343 µM -0.214415857006785 0.40858462499096 no 2022 0.415111388549591 2819 5207356
SGTC_2458 5808907 16.39 µM -0.216387618996289 0.407763764089481 no 2023 0.414342808138864 2911 2731747
SGTC_2610 ononetin 44.17 µM -0.216411692094646 0.407753744752277 no 2024 0.414333426616699 2856 259632
SGTC_2787 5284540 71.43 µM -0.216891494579182 0.407554061285716 no 2025 0.41414645309159 2874 736958
SGTC_904 1141-0088 396 µM -0.216956356297777 0.407527069076254 no 2026 0.414121178715761 2827 1378119
SGTC_2717 st081029 62.2815 µM -0.217140942586344 0.407450255880189 no 2027 0.414049253748792 2880 5292846
SGTC_1829 berberine 14.4 µM -0.217754719729587 0.407194866066457 no 2028 0.413810113169813 2946 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2935 9038016 29.96 µM -0.218392871669827 0.406929375844508 no 2029 0.413561509543406 2899 6463195
SGTC_371 0195-0006 7.36 µM -0.219623987679363 0.406417315826565 no 2030 0.413082004015681 2736 3928593
SGTC_1626 st003712 1.76 µM -0.221167019568515 0.405775746176709 no 2031 0.412481193980987 2956 24207035
SGTC_2204 7233102 200 µM -0.221959358020124 0.405446401867559 no 2032 0.412172760883161 2813 2172480
SGTC_200 k038-0079 37.545 µM -0.223289994013756 0.404893458884529 no 2033 0.411654907156659 2831 3436683
SGTC_1292 0kpi-0043 232 µM -0.224569279340562 0.404362033530859 no 2034 0.411157182998899 2854 3333905
SGTC_2861 9024595 19.48 µM -0.225012080548596 0.404178131416686 no 2035 0.410984938157149 2847 16482810
SGTC_2536 dehydroabietamide 32.04 µM -0.225159426970272 0.404116940887245 no 2036 0.410927625809485 2965 3983547
SGTC_1115 galangin 695.678 nM -0.225729669721122 0.403880150634192 no 2037 0.410705840246935 2832 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3280 9140961 49.47 µM -0.225932226903841 0.403796048319949 no 2038 0.410627066176522 2774 4901226
SGTC_2447 5741742 33.78 µM -0.227477532490974 0.403154579739606 no 2039 0.410026218902805 2889 1776504
SGTC_269 exalamide 29 µM -0.227899605776843 0.402979419002081 no 2040 0.409862144601878 2830 3316 A derivative of salicylamide.
SGTC_2629 bisabolol 100 µM -0.228252803115792 0.402832856795874 no 2041 0.409724856861375 2961 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_719 2810-4230 27.3 µM -0.228468552733412 0.402743336393178 no 2042 0.409641000468851 2790 721079
SGTC_599 1935-0052 86.5 µM -0.2292427879185 0.402422127101944 no 2043 0.409340108988802 2808 9557311
SGTC_908 3448-7491 47.7 µM -0.230073628821193 0.402077506899115 no 2044 0.409017278198506 2811 1203031
SGTC_2196 6573537 42.6665 µM -0.230417671436935 0.401934825509498 no 2045 0.408883615364481 2909 2903087
SGTC_942 3253-1115 227 µM -0.230783841189196 0.401782981908281 no 2046 0.408741367631364 2985 46497897
SGTC_1018 4259-0013 28.1 µM -0.232091726408033 0.401240748094105 no 2047 0.4082333854096 2956 6801262
SGTC_1065 prochlorperazine maleate 2.48 µM -0.232752563907831 0.400966844891789 no 2048 0.407976774904103 2830 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1807 st050092 58.9 µM -0.233522385339383 0.400647831531723 no 2049 0.407677894507116 2831 5008496
SGTC_2733 amorolfine 100 µM -0.233863336169131 0.400506562949269 no 2050 0.407545538732618 2849 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2216 7189485 200 µM -0.233918032491897 0.400483901443641 no 2051 0.407524306816598 2922 731273
SGTC_394 menadione 8.33 µM -0.234051391117906 0.400428650371973 no 2052 0.407472541053902 2909 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1975 st070967 30.8 µM -0.234417674311734 0.400276907870888 no 2053 0.407330369373934 2946 261391
SGTC_2904 7225135 42.03 µM -0.237329054114327 0.399071328895429 no 2054 0.406200761973544 2917 4446116
SGTC_3142 9086498 49.47 µM -0.237598400390136 0.398959843214361 no 2055 0.406096295648038 2963 25236367
SGTC_1177 0983-0204 23.6 µM -0.237968515589768 0.398806661503107 no 2056 0.40595275686231 2966 766818
SGTC_2031 5180455 200 µM -0.238056444051138 0.398770272334227 no 2057 0.405918658135689 2821 29949
SGTC_1667 st014849 34.6 µM -0.238202151203763 0.3987099734077 no 2058 0.405862154358534 2789 5348460
SGTC_812 4251-0442 148 µM -0.239134826911923 0.398324055557989 no 2059 0.405500518543531 2876 5723007
SGTC_1726 st035556 14.5795 µM -0.239372703441189 0.398225644105588 no 2060 0.405408297159282 3034 5919439
SGTC_2940 9060638 45.86 µM -0.239593353270778 0.398134365265706 no 2061 0.405322759018469 2944 4027022
SGTC_1108 betulinic acid 729.144 nM -0.239705299330831 0.398088057338531 no 2062 0.405279363216174 2865 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2121 5257820 149.641 µM -0.239842311853482 0.398031382300461 no 2063 0.40522625200416 2975 791256
SGTC_2616 abietic acid 100 µM -0.239938298351208 0.397991678901643 no 2064 0.405189045063525 2932 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.240007361268752 0.397963112698008 no 2065 0.405162274954648 2823 2724278 An inhibitor of dopamine biosynthesis.
SGTC_502 l-744,832 89.3 µM -0.241135723007632 0.397496470765024 no 2066 0.404724963280289 2960 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_1397 3532-0190 20.1 µM -0.241170154266048 0.397482233778416 no 2067 0.404711620853748 2792 5322280
SGTC_611 3453-1652 23.7 µM -0.241221842700021 0.397460861375895 no 2068 0.404691591322357 2931 1560575
SGTC_697 0508-1955 564 µM -0.242634078645075 0.39687704202138 no 2069 0.404144439497277 2968 6243113
SGTC_1384 3089-0840 101 µM -0.244336883715391 0.396173408530906 no 2070 0.403484959939615 2959 1069836
SGTC_1253 0550-0034 176 µM -0.245817113310208 0.395562022330821 no 2071 0.402911904480256 2967 5969915
SGTC_3056 9094900 49.47 µM -0.246768465267078 0.395169216479297 no 2072 0.402543708464538 2882 25236784
SGTC_677 0929-0063 136 µM -0.247309955057194 0.394945687076157 no 2073 0.402334177510359 2840 1539583
SGTC_815 1582-0027 36.9 µM -0.247920241372856 0.394693799603513 no 2074 0.402098059186708 2947 3128206
SGTC_13 0199-0087 65 µM -0.247969989358006 0.394673268730266 no 2075 0.402078813383153 2837 4589825
SGTC_2466 5983409 37.09 µM -0.248585390944204 0.394419318191443 no 2076 0.401840755086721 2876 2879657
SGTC_2704 st078022 71.1 µM -0.248637351874494 0.394397878137774 no 2077 0.401820656494874 3003 54697681
SGTC_2885 9057732 51.95 µM -0.248720500312417 0.394363570199564 no 2078 0.401788495052874 3004 6471414
SGTC_2790 5423970 71.43 µM -0.249265714913172 0.394138629116997 no 2079 0.401577624985076 3026 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2109 5483026 200 µM -0.25001826418021 0.393828205262776 no 2080 0.401286612157033 2886 759335
SGTC_1201 1889-3372 45.9 µM -0.250166163748899 0.393767205149751 no 2081 0.401229425427993 2877 5392199
SGTC_218 alverine citrate 93.75 µM -0.250192040473222 0.393756532748867 no 2082 0.401219420171891 2979 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2869 9037858 32.47 µM -0.251099554111567 0.393382295203242 no 2083 0.400868570315883 2806 27187042
SGTC_2068 5226020 147 µM -0.251650950141804 0.393154960362445 no 2084 0.400655436546176 2892 1810509
SGTC_2100 5377183 190 µM -0.252053242783807 0.392989122276474 no 2085 0.400499955084003 2943 2844202
SGTC_3103 9120822 49.47 µM -0.252476109842075 0.392814823683853 no 2086 0.400336538842783 3087 17141819
SGTC_3061 glucosamine 200 µM -0.25595883114043 0.391380125728144 no 2087 0.398991313280356 2912 91431 and experimental redox chemotherapeutic
SGTC_2738 aclarubicin 5.55 µM -0.257768013745473 0.390635419109688 no 2088 0.398292975889929 2936 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3096 9117468 49.47 µM -0.25920795088772 0.390042989952776 no 2089 0.397737398392832 3002 41316311
SGTC_432 NS 1619 61.3 µM -0.26040008604155 0.389552706360358 no 2090 0.397277588295271 3028 4552 A K+/calcium channel activator.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.262288076153677 0.388776601705626 no 2091 0.396549677087416 2856 23665772 A membrane-active detergent.
SGTC_905 2-aminofluorene 215 µM -0.262811224805374 0.388561626991821 no 2092 0.396348041721045 2873 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2987 9018338 71.43 µM -0.264453741388759 0.387886898384703 no 2093 0.395715152648551 2859 5055682
SGTC_2918 7977171 22.06 µM -0.264519878420244 0.387859737057788 no 2094 0.395689674691356 2831 2236483
SGTC_3302 9125395 16.351 µM -0.264676317047791 0.387795492622155 no 2095 0.395629411640177 2914 17599668
SGTC_2526 patulin 37.61 µM -0.265200251204564 0.387580351682145 no 2096 0.395427600697789 3014 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1504 k297-0033 30 µM -0.265621679285048 0.387407327435356 no 2097 0.395265293778714 2838 4388117
SGTC_2063 5246145 200 µM -0.265830778453339 0.38732148662249 no 2098 0.39518476900544 2999 711240
SGTC_1518 st038567 90.8 µM -0.268300783610207 0.386307901286349 no 2099 0.394233901546681 2866 77966
SGTC_1078 idebenone 36.1 µM -0.270366034944056 0.385461004574257 no 2100 0.393439333786757 2949 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_932 2857-0803 154 µM -0.271439022386435 0.385021220284694 no 2101 0.393026696332955 3116 674898
SGTC_2255 7941087 197.44 µM -0.271784666763351 0.384879582830029 no 2102 0.392893797870131 3040 935561
SGTC_3201 9113999 49.47 µM -0.271901139851974 0.384831858182309 no 2103 0.392849017385589 3089 16649224
SGTC_1290 0986-0249 10.2 µM -0.272126581650501 0.384739488751007 no 2104 0.392762345659328 2953 53329
SGTC_3079 9117512 49.47 µM -0.273765151675974 0.384068320422318 no 2105 0.392132552879124 2877 7185044
SGTC_537 1334-0398 209 µM -0.27415451565865 0.383908885574416 no 2106 0.391982940313029 3058 5846986
SGTC_2496 diffractaic acid 79.83 µM -0.274437211851314 0.383793140837451 no 2107 0.391874324701458 3142 94870 An apoptosis inducer which activates caspases.
SGTC_993 3909-8757 62.7 µM -0.275125312378616 0.383511454124378 no 2108 0.391609982621954 2928 4288324 YLR208W SEC13
SGTC_2652 actinonin 100 µM -0.275674866377706 0.383286528208907 no 2109 0.39139890078966 2875 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_555 4296-0685 37 µM -0.275898667563172 0.383194940312797 no 2110 0.391312948670496 2919 2908540 YHR072W ERG7
SGTC_3245 9134821 49.47 µM -0.275993192229337 0.383156259210709 no 2111 0.391276647528294 2904 17014901
SGTC_2118 5526350 200 µM -0.276566329418179 0.382921746678042 no 2112 0.39105656088298 2998 743594
SGTC_277 nystatin 15.5 µM -0.276987475634636 0.382749452163812 no 2113 0.390894861522116 2858 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_684 1140-0066 328 µM -0.277814512163017 0.382411172001957 no 2114 0.390577375228219 2955 6813534
SGTC_3171 9103192 49.47 µM -0.278439818374424 0.382155464504807 no 2115 0.390337378435461 2978 13018434
SGTC_85 0868-0259 160.055 µM -0.279605827099879 0.381678783977386 no 2116 0.389889967989526 2948 83173
SGTC_634 1611-4317 11.2 µM -0.281017460758632 0.381101928658074 no 2117 0.389348503753931 2913 2843522
SGTC_1510 1123-0200 71.5 µM -0.281388916544268 0.380950179401353 no 2118 0.389206059077873 3094 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_100 0086-0128 49.5915 µM -0.282517127942961 0.380489388325151 no 2119 0.388773507536841 2939 93297
SGTC_3340 9146634 11.102 µM -0.282536886739026 0.380481319823998 no 2120 0.388765933323669 2979 4907387
SGTC_2842 9000675 19.48 µM -0.283674600121946 0.380016822543 no 2121 0.388329880797561 2966 2989072
SGTC_2191 5911152 200 µM -0.287057166602056 0.378636837380312 no 2122 0.387034274304161 2960 2875902
SGTC_2721 ifenprodil 61.44 µM -0.28769808585645 0.37837553533495 no 2123 0.386788927685225 3064 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2746 daunorubicin 9.88 µM -0.290716170002621 0.377145815196728 no 2124 0.385634201809264 2942 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2518 prenyletin 46.28 µM -0.291095067342763 0.376991520955354 no 2125 0.385489306174954 3019 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1165 k072-0275 30.3 µM -0.292756222084165 0.376315299096279 no 2126 0.384854246267137 3023 6153523 YGL055W OLE1
SGTC_3252 9135871 49.47 µM -0.293079536150098 0.376183728655757 no 2127 0.384730679057947 3068 17682838
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.295549173147911 0.375179202565247 no 2128 0.38378719712149 3032 140250 A respiratory chain inhibitor.
SGTC_3004 9076122 71.4286 µM -0.298143910433111 0.374124703169711 no 2129 0.382796664472295 3093 44782551
SGTC_1105 epirubicin 18.1 µM -0.300619250365207 0.373119603732968 no 2130 0.381852425218448 2912 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2625 euphol 100 µM -0.301104558994315 0.372922647540916 no 2131 0.381667382343953 3083 6708538 A triterpene alcohol.
SGTC_2968 9090663 33.37 µM -0.302703093254868 0.372274138324342 no 2132 0.381058070125008 3008 25236811
SGTC_3296 9122258 64.045 µM -0.305116851893683 0.371295587387661 no 2133 0.380138578419379 3034 4730474
SGTC_3321 9137793 26.8275 µM -0.306306049329391 0.370813785549289 no 2134 0.379685816871435 2972 4904192
SGTC_332 4112-0506 40.9 µM -0.306477783435374 0.370744224407772 no 2135 0.379620446387036 2941 2790355
SGTC_2004 4023728 41.89 µM -0.309236405191907 0.369627421195374 no 2136 0.378570851386555 3108 360084 YDR527W RBA50
SGTC_320 4092-0846 5.34 µM -0.310329264270422 0.369185290409932 no 2137 0.378155289616178 3045 1359356
SGTC_1813 st051246 8.6015 µM -0.31125530867819 0.368810782107195 no 2138 0.377803269718358 3052 5291959
SGTC_1893 st059353 36.1 µM -0.311499537789881 0.368712032388979 no 2139 0.377710447105628 3015 3112488
SGTC_1370 2001-0092 44.6 µM -0.312876647597783 0.36815538482122 no 2140 0.377187190004349 3189 790957
SGTC_871 0574-0004 149 µM -0.314581565036797 0.367466616109527 no 2141 0.376539688998371 2950 9551173
SGTC_739 1486-1183 203 µM -0.315114957940678 0.367251218397619 no 2142 0.376337185927681 3092 4346692
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.315352925357816 0.367155134531789 no 2143 0.376246852370773 2965 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3077 9117319 49.47 µM -0.319246645321941 0.365584156826153 no 2144 0.374769744091031 2938 17154678
SGTC_2245 6637752 200 µM -0.319406595050554 0.365519670769647 no 2145 0.374709105209889 3089 681890
SGTC_1668 st014914 51.6 µM -0.32051564881255 0.365072644272222 no 2146 0.374288734768815 3034 2839556
SGTC_1053 3366-3204 134 µM -0.320786398836558 0.364963540825993 no 2147 0.374186133643663 3022 3632071 YPR165W RHO1
SGTC_2521 angolensin 13.4 µM -0.321818536123642 0.364547723438853 no 2148 0.373795085470859 3129 821428 A flavenoid.
SGTC_457 grayanotoxin iii 135 µM -0.322525143257439 0.36426314430222 no 2149 0.373527446504506 3028 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1857 st056007 79.3 µM -0.322777390849959 0.36416157215587 no 2150 0.373431918384017 3046 619834
SGTC_1141 3253-0389 52.6 µM -0.323550094319607 0.363850488253089 no 2151 0.373139338011292 3077 5402031
SGTC_80 0159-0065 512.242 µM -0.324361861944442 0.363523774085058 no 2152 0.372832044969071 2938 1548079
SGTC_1809 st050081 57.6 µM -0.325495789666699 0.363067565492748 no 2153 0.372402934326732 3150 5036894
SGTC_1061 3448-9325 110 µM -0.326171967333848 0.362795614042438 no 2154 0.37214712471738 3010 723482
SGTC_2048 5246248 200 µM -0.32660893165739 0.362619908442453 no 2155 0.371981843619285 3102 677046
SGTC_1278 0874-0585 172 µM -0.327668741310401 0.362193873760655 no 2156 0.371581070245783 3056 766306
SGTC_3055 9094636 49.47 µM -0.329145596572569 0.361600474889959 no 2157 0.371022820723672 3167 25236176
SGTC_222 nsc-310342 10.666 µM -0.330069189661761 0.361229545162174 no 2158 0.370673841456764 3071 432556
SGTC_2648 atorvastatin 78.68 µM -0.330108642985984 0.361213702979774 no 2159 0.370658936401597 3078 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1287 0971-0001 34.6 µM -0.330251489405371 0.3611563460772 no 2160 0.37060497213538 3015 4665869
SGTC_2980 9014342 25.29 µM -0.330824511844721 0.360926292646859 no 2161 0.370388522336049 3148 2996599
SGTC_1581 himbacine 57.9 µM -0.331366428114076 0.360708773805793 no 2162 0.370183860127746 2981 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1640 st009078 66.4 µM -0.3317054075483 0.360572734334242 no 2163 0.370055858514201 3107 690618
SGTC_3109 9122853 49.47 µM -0.332054170519455 0.360432786942427 no 2164 0.369924177572173 3027 1234709
SGTC_1344 1488-0097 29.1 µM -0.332586562893352 0.360219191018632 no 2165 0.3697231938731 3096 747966
SGTC_3035 9091303 49.47 µM -0.332698512046666 0.360174282545536 no 2166 0.369680936421081 3003 25237002
SGTC_468 gf-109203x 121 µM -0.332760944352398 0.360149238624931 no 2167 0.369657370779356 3046 2396 A protein kinase C inhibitor.
SGTC_1911 st060208 74.3 µM -0.335112587629272 0.359206344956488 no 2168 0.368770078884003 3098 688783
SGTC_359 0081-0058 15.9 µM -0.336159644133188 0.358786801974389 no 2169 0.368375241575843 3366 3494159
SGTC_2150 5556613 200 µM -0.336310060399983 0.358726545959729 no 2170 0.368318532112967 3030 743190
SGTC_1688 st021091 57.6 µM -0.33679184988474 0.358533567141898 no 2171 0.368136908687893 3123 3656366
SGTC_1563 conessine 56.1 µM -0.336849037451208 0.358510663291891 no 2172 0.368115352261807 3088 441082 An anti-amoebic, histamine inhibitor.
SGTC_456 gingerol 170 µM -0.338491833433323 0.357852934498013 no 2173 0.367496290130079 3190 442793 A herb.
SGTC_1776 st049249 45.9 µM -0.339702694962376 0.357368409869409 no 2174 0.367040216015558 3042 1822314
SGTC_2948 9070189 9.45 µM -0.339821978668419 0.357320691077613 no 2175 0.366995297639219 3135 6473636 YDL196W YDL196W
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.340039467642133 0.357233691550563 no 2176 0.366913403029733 3205 551469
SGTC_3348 9149464 3.537 µM -0.340607996506689 0.357006304777279 no 2177 0.366699354359819 2996 1951442
SGTC_528 3492-0019 172 µM -0.341829245398892 0.356518030238744 no 2178 0.366239699623473 3081 2869262
SGTC_2197 6588183 93.1375 µM -0.343491130603334 0.355853960074443 no 2179 0.365614506083782 3009 884136
SGTC_1611 st001856 99.4 µM -0.343970225889526 0.355662600209676 no 2180 0.365434338836018 3052 647478
SGTC_1218 1348-1416 30.7 µM -0.344395196692603 0.355492889140998 no 2181 0.365274550337149 2988 6787668
SGTC_2971 9092186 9.93 µM -0.34439971583483 0.355491084586294 no 2182 0.365272851270847 2953 25236400
SGTC_1850 st056238 17 µM -0.344746041444711 0.355352801718726 no 2183 0.36514265076309 3002 5393177
SGTC_1769 st044406 64.4 µM -0.344861785308194 0.355306591092374 no 2184 0.365099140524805 2995 670903
SGTC_1234 0326-0494 15.5 µM -0.345245746093521 0.355153310355623 no 2185 0.364954815072252 3152 1547813
SGTC_1382 3002-2117 298 µM -0.345402606141291 0.355090697098544 no 2186 0.364895859092183 3166 1497314
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.347093644988791 0.354415940019187 no 2187 0.364260483821728 3062 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2360 9040895 200 µM -0.347472040310367 0.354265015450581 no 2188 0.36411836005871 3060 4914414
SGTC_2478 5763493 32.33 µM -0.348318360239348 0.353927540047269 no 2189 0.363800553351141 3010 1365576 YLR208W SEC13
SGTC_870 0573-2213 57.6 µM -0.349006561109029 0.353653200178088 no 2190 0.363542191932839 3017 3916321
SGTC_1826 st055655 41.6 µM -0.349012318077193 0.353650905578464 no 2191 0.363540030938089 3090 676168
SGTC_3267 9137951 49.47 µM -0.349608670475466 0.353413241578894 no 2192 0.363316201503812 2962 16643986
SGTC_2279 7948423 32.93 µM -0.350131762944055 0.353204820860864 no 2193 0.363119907191745 3204 1247112
SGTC_2219 9098279 200 µM -0.350192796210841 0.353180505661393 no 2194 0.363097006348603 3110 902349
SGTC_3149 9097855 49.47 µM -0.352156829844917 0.35239836975404 no 2195 0.362360325272997 3160 25236625 YMR079W SEC14
SGTC_3164 9100705 49.47 µM -0.352440903610744 0.352285294788553 no 2196 0.362253815349268 3150 17174235
SGTC_758 0868-0029 16 µM -0.352685324552932 0.35218801399538 no 2197 0.362162181292468 3134 762687
SGTC_1424 4048-1941 275 µM -0.35353149370224 0.351851309049777 no 2198 0.361845011280305 3168 X1424
SGTC_1042 0350-0096 82 µM -0.353708914123297 0.351780725199943 no 2199 0.361778520717981 3024 3122515
SGTC_857 0438-0306 1.35 µM -0.353845971290006 0.351726202716372 no 2200 0.361727159655779 3115 4686136
SGTC_152 4469-0003 551.229 µM -0.355533630289619 0.351055088167609 no 2201 0.361094927554264 3051 697280
SGTC_1166 k206-0078 225 µM -0.355576188771892 0.351038170353071 no 2202 0.361078989158863 3013 5404595
SGTC_3133 9127736 49.47 µM -0.35603079973528 0.350857472187159 no 2203 0.360908749802786 3224 27243420
SGTC_1338 1486-1223 76 µM -0.35665252032041 0.350610406118502 no 2204 0.360675977080854 3097 3444526
SGTC_136 0097-0015 404.482 µM -0.356876835672902 0.35052128075425 no 2205 0.360592005885074 3112 4861337
SGTC_562 3772-2733 112 µM -0.357402799849348 0.350312336028994 no 2206 0.360395140506662 3163 2876874 YIL048W NEO1
SGTC_1058 3448-5425 97.3 µM -0.358729451070372 0.349785511396987 no 2207 0.359898747038484 3040 7279705
SGTC_849 0386-0493 241 µM -0.35979774989128 0.349361490793859 no 2208 0.359499192995222 3018 726119
SGTC_2435 5706476 10.6 µM -0.360163025608039 0.349216551572066 no 2209 0.35936261156721 3187 5725375
SGTC_597 k018-0003 82.8 µM -0.361691883963142 0.348610148544816 no 2210 0.3587911463432 3162 6786234
SGTC_2481 5478948 45.16 µM -0.362095667982503 0.348450057012102 no 2211 0.358640270383874 3181 77792
SGTC_2677 mitomycin C 100 µM -0.362394562592714 0.348331569219191 no 2212 0.358528601093493 3060 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_39 0986-0283 58.349 µM -0.362822149102319 0.348162091119644 no 2213 0.358368872564589 3231 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_231 b-estradiol 524 µM -0.362997145325693 0.348092738394571 no 2214 0.358303508400888 3034 450 A steroid.
SGTC_1257 0669-0121 16 µM -0.363310084901438 0.34796873002862 no 2215 0.358186630324145 3105 4307855
SGTC_3207 9114163 49.47 µM -0.363586637137549 0.347859154382403 no 2216 0.358083353413816 3301 849233
SGTC_2041 5107442 45.335 µM -0.363627900928598 0.347842805914406 no 2217 0.358067944568294 3203 793005
SGTC_2224 6650123 117.647 µM -0.36427263479929 0.347587402955923 no 2218 0.357827216203422 3066 2908370
SGTC_648 0375-0473 33.3 µM -0.366220267629744 0.34681629393795 no 2219 0.357100359882026 3047 1713139
SGTC_1763 st044482 94.5 µM -0.367041748695528 0.34649124214764 no 2220 0.356793938511296 3174 88505
SGTC_2493 resveratrol 26.09 µM -0.368146494343734 0.34605428361776 no 2221 0.356382002053599 2998 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3241 9133421 49.47 µM -0.370926298532534 0.344955699012384 no 2222 0.355346213417116 3106 17018221
SGTC_900 1112-0045 141 µM -0.371822153627139 0.344601932896566 no 2223 0.355012634088097 3100 56211 YIL048W NEO1
SGTC_1723 st034307 2.5525 µM -0.371973506022727 0.344542178436121 no 2224 0.354956287689251 3124 867466
SGTC_3005 9076496 71.4286 µM -0.372596738213894 0.344296165053164 no 2225 0.354724300420373 3164 21368410
SGTC_637 1181-0519 7.26 µM -0.373720345211899 0.343852801235259 no 2226 0.354306193539253 3081 6252091 YGR060W ERG25
SGTC_2684 capsaicin 100 µM -0.374223926884887 0.343654162682063 no 2227 0.354118862036772 3167 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2898 9056270 58.44 µM -0.375587754904013 0.343116415519764 no 2228 0.353611697769242 3128 19154699
SGTC_1935 st074532 41.6 µM -0.376662528689074 0.342692863937967 no 2229 0.353212206524174 3164 2829742
SGTC_2735 sertaconazole 140 nM -0.376688700120965 0.342682552648267 no 2230 0.353202480670786 3117 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2617 dihydrotanshinone i 20.83 µM -0.378217277571633 0.34208051156691 no 2231 0.352634595738048 3052 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_431 k089-0097 107 µM -0.378891448787012 0.341815111861119 no 2232 0.352384237246969 3161 5499420
SGTC_53 0973-0023 39.979 µM -0.379113205870371 0.341727830246709 no 2233 0.35230190007692 3245 674768
SGTC_924 2046-0044 21.3 µM -0.379600832073211 0.341535934674934 no 2234 0.352120871533199 3032 3623589
SGTC_584 0986-0246 15.4 µM -0.381395992199506 0.340829838418964 no 2235 0.35145471722684 3185 53315 YDR232W HEM1
SGTC_952 1185-0122 232 µM -0.382632804666424 0.340343682950007 no 2236 0.350996021690789 3036 678600
SGTC_3007 9078383 71.4286 µM -0.382884941058989 0.340244607892997 no 2237 0.350902538703222 3084 6496995
SGTC_2136 5328288 199.296 µM -0.383181548122342 0.340128072544671 no 2238 0.350792579163847 3084 262395
SGTC_2791 5663188 71.43 µM -0.385422115460883 0.339248259519317 no 2239 0.34996235002925 3246 54690634
SGTC_503 tyrphostin 8 294 µM -0.388076375065867 0.338207133528899 no 2240 0.348979757266395 3181 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2083 5306046 65.942 µM -0.388146212862154 0.338179756500479 no 2241 0.348953917319192 3109 539837
SGTC_3148 9097893 49.47 µM -0.39055669014836 0.337235353554693 no 2242 0.348062472056821 3062 17174100
SGTC_1202 1988-0068 29.6 µM -0.390891921815549 0.337104093884319 no 2243 0.347938562668659 3096 2850480
SGTC_806 3966-4455 5.86 µM -0.39144074687404 0.336889244717264 no 2244 0.34773573927032 3095 714982
SGTC_1265 0819-1001 68.8 µM -0.392939183598687 0.336302921128826 no 2245 0.347182200074968 3170 3106768
SGTC_1618 st003135 44.5 µM -0.394732778719406 0.335601628218282 no 2246 0.346520054591429 3175 1270615
SGTC_3228 9131799 49.47 µM -0.395428663396728 0.335329692337652 no 2247 0.346263279386075 3150 17015818
SGTC_1485 3909-9022 254 µM -0.395911747527685 0.335140964779441 no 2248 0.346085067212733 3172 714516
SGTC_2058 5236698 133 µM -0.39660914575797 0.334868584057024 no 2249 0.345827853610811 3116 766665
SGTC_1691 st019933 84.6 µM -0.398665357394246 0.334066001642457 no 2250 0.3450698984845 3189 6176082
SGTC_146 3448-8650 53.125 µM -0.399814256959966 0.333617892043231 no 2251 0.344646664545858 3111 2891488 YIL048W NEO1
SGTC_159 3970-0959 50 µM -0.400218641823429 0.333460224718407 no 2252 0.3444977426562 3265 6615653
SGTC_3147 9097027 49.47 µM -0.400280832992524 0.333435979349565 no 2253 0.344474841794144 3115 25236841
SGTC_348 k064-0012 10.7 µM -0.403318163881909 0.332252717499912 no 2254 0.343357090539248 3068 5066323
SGTC_34 0469-0683 81.75 µM -0.403632091814523 0.332130514719858 no 2255 0.343241641545533 3185 3690923
SGTC_480 am 92016 50 µM -0.404637959134246 0.331739080853086 no 2256 0.342871826011321 3184 2129 K+ channel blocker.
SGTC_2945 9067681 61.76 µM -0.404763531863056 0.331690227035741 no 2257 0.342825668706964 3181 16456930
SGTC_2248 tofa 1.1 µM -0.405121453997018 0.331550993859672 no 2258 0.342694118614431 3044 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1172 0370-0043 85 µM -0.405324955176512 0.331471841443607 no 2259 0.34261933264122 3240 376585
SGTC_587 k089-0003 57 µM -0.405698938880537 0.331326398946567 no 2260 0.342481911021431 3185 9659696
SGTC_297 0986-0032 24 µM -0.406440318343329 0.331038151220972 no 2261 0.342209550192047 3109 2847425
SGTC_2469 5655019 90.81 µM -0.407606238853412 0.330585044855934 no 2262 0.341781391614052 3241 2788239
SGTC_750 4073-0104 132 µM -0.408557334721702 0.330215608573021 no 2263 0.341432273280844 3158 22330957
SGTC_1772 st048439 82.2 µM -0.409624673938207 0.329801216658935 no 2264 0.341040647078557 3198 2927068 YDL195W SEC31
SGTC_72 0744-0168 198.391 µM -0.409735660837692 0.329758138236345 no 2265 0.340999933782714 3036 677577
SGTC_2443 5493264 126.67 µM -0.410107743733431 0.329613734568753 no 2266 0.340863456219583 3247 5340055
SGTC_2824 7998404 51.95 µM -0.410730090076617 0.329372261581945 no 2267 0.340635230218846 3090 837851
SGTC_965 1291-5240 308 µM -0.411112239734505 0.329224021163879 no 2268 0.340495117719551 3249 2834598
SGTC_2400 5203494 178.7 µM -0.412440084614287 0.328709143088682 no 2269 0.340008443902869 3165 6777674
SGTC_414 piperonyl butoxide 100 µM -0.412696984664225 0.328609566379365 no 2270 0.339914317163516 3119 5794 A potent inhibitor of cytochrome P450.
SGTC_810 3825-7150 143 µM -0.41420064853576 0.328026977352692 no 2271 0.339363583448459 3295 22330411 YGL099W LSG1
SGTC_1512 0259-0544 12.2 µM -0.414602144420853 0.327871489926447 no 2272 0.339216589049015 3152 18476
SGTC_1050 3232-1156 69.3 µM -0.414826122623199 0.327784762785726 no 2273 0.33913459749067 3170 700529
SGTC_1137 ixabepilone 100 µM -0.415220668818982 0.32763201219401 no 2274 0.338990184745584 3147 154225 A novel microtubule stabilizer.
SGTC_923 1900-2434 73.3 µM -0.415814764479409 0.32740205942029 no 2275 0.338772777061575 3094 5910570
SGTC_1665 st014639 11.4 µM -0.418925733397108 0.32619898753468 no 2276 0.337635204798041 3203 981133 YIL048W NEO1
SGTC_2513 baicalein 25.65 µM -0.419005710780361 0.326168082497977 no 2277 0.337605979368243 3174 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1554 st069299 38.7 µM -0.4190596954729 0.326147222288944 no 2278 0.3375862527718 3217 24207999
SGTC_2168 5727979 200 µM -0.419082150117875 0.32613854575642 no 2279 0.33757804773062 3167 695210
SGTC_514 4466-0038 2.65 nM -0.419344330830052 0.3260372454213 no 2280 0.337482251283192 3137 5722064
SGTC_1919 st067113 52.3 µM -0.419976284560746 0.325793126440304 no 2281 0.337251389256114 3249 1268243
SGTC_2836 9010338 19.48 µM -0.420228903802191 0.325695562409868 no 2282 0.337159120853406 3128 2994051
SGTC_1575 cyproterone acetate 48 µM -0.420444712711224 0.325612224346103 no 2283 0.337080305069141 3169 9880 An androgen receptor antagonist and liver toxin.
SGTC_1737 st035557 69.7 µM -0.423519008326884 0.324425984033628 no 2284 0.335958316516117 3176 5716916
SGTC_193 1273-0060 1.558 µM -0.424943259675929 0.323877028190604 no 2285 0.335439019006329 3212 2847393 YHR072W ERG7
SGTC_2802 7925815 54.55 µM -0.425098578511221 0.323817186059295 no 2286 0.335382407057034 3127 1262923
SGTC_1782 st039423 80.636 µM -0.426226526411123 0.323382740531235 no 2287 0.334971395077208 3170 2068169
SGTC_2277 7947813 106.88 µM -0.426428861243486 0.323304833774085 no 2288 0.334897687343755 3333 1246798
SGTC_1999 st074831 12.5 µM -0.426678522060466 0.323208715355408 no 2289 0.334806748184498 3153 17112523
SGTC_2312 7706453 155.7 µM -0.426822214832229 0.323153399561745 no 2290 0.334754412365174 3150 976098
SGTC_3253 9135987 49.47 µM -0.427019889570348 0.323077309326198 no 2291 0.334682420464921 3252 4182430
SGTC_1159 4092-0538 61.2 µM -0.427351759431919 0.322949580486154 no 2292 0.334561569208024 3175 717301
SGTC_1788 fluconazole 20 µM -0.427370186220402 0.32294248906391 no 2293 0.334554859548099 3238 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2900 5328528 85.29 µM -0.427523772335814 0.322883385012792 no 2294 0.334498937013177 3173 795359
SGTC_1391 3442-0225 151 µM -0.427955317901447 0.322717338665115 no 2295 0.334341825786546 3119 5227075
SGTC_988 1497-1057 103 µM -0.428212523085091 0.322618390300157 no 2296 0.334248199827118 3298 3533044
SGTC_2819 7996655 46.38 µM -0.42849124421497 0.322511178803231 no 2297 0.334146753430838 3160 6456960
SGTC_286 k060-0067 22.9 µM -0.428560665400566 0.322484477887173 no 2298 0.334121488019778 3180 5985051
SGTC_2260 7964312 200 µM -0.428872231135737 0.322364654124903 no 2299 0.334008104856218 3298 231951
SGTC_2976 9009005 19.48 µM -0.429550618111217 0.32210381996208 no 2300 0.333761282687394 3313 2993148
SGTC_41 0478-0632 82.643 µM -0.431102473442711 0.321507474007202 no 2301 0.33319693112257 3280 3750424
SGTC_1324 1418-0026 34.4 µM -0.432026701666151 0.321152530503656 no 2302 0.33286100324816 3244 1372513
SGTC_1182 1222-0449 220 µM -0.432447149269562 0.320991114517758 no 2303 0.332708228141773 3230 658318
SGTC_1036 k216-0215 33.5 µM -0.432981554915043 0.320785997192699 no 2304 0.332514084988933 3140 622330
SGTC_940 3232-1287 54.8 µM -0.435414256661502 0.319852961630559 no 2305 0.331630881960428 3269 1585493 YIL048W NEO1
SGTC_2233 sulbentine 40.3845 µM -0.435446541614251 0.31984058674096 no 2306 0.331619167044294 3215 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1956 st077085 54 µM -0.435667765383629 0.319755796604464 no 2307 0.331538898230966 3189 24208685
SGTC_235 0330-0087 5 mM -0.436296862615312 0.31951472915259 no 2308 0.331310678935138 3205 46494818 YHR062C RPP1
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.436893152701304 0.319286303649081 no 2309 0.331094418992004 3242 6708739 YPR165W RHO1
SGTC_1878 temozolomide 1 mM -0.437826679744541 0.318928827894655 no 2310 0.330755964541153 3274 5394 DNA alkylating agent.
SGTC_1802 st050112 57.9 µM -0.438309730878923 0.318743919076655 no 2311 0.330580886451844 3206 4662563
SGTC_2161 5662504 8.5105 µM -0.438458093491207 0.318687135892686 no 2312 0.330527121027035 3181 2859334
SGTC_3083 9117465 49.47 µM -0.438774033922494 0.318566229428561 no 2313 0.330412638395138 3243 16420915
SGTC_2003 4023581 200 µM -0.43887255552067 0.318528530391579 no 2314 0.330376941835358 3287 16641307
SGTC_3320 9137005 35.139 µM -0.439171680471681 0.318414082507876 no 2315 0.330268571690331 3215 4908713
SGTC_2937 9044753 11.33 µM -0.441598900292899 0.317486048000115 no 2316 0.329389739963957 3152 6465530 YGL099W LSG1
SGTC_662 k832-1615 104 µM -0.442123566404327 0.317285595149225 no 2317 0.3291998959293 3253 5878478
SGTC_1121 fusaric acid 630.51 nM -0.443067583552522 0.316925060879114 no 2318 0.32885842575192 3163 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3317 9138495 8.753 µM -0.443140719216561 0.316897136523363 no 2319 0.328831977053446 3239 17020139
SGTC_1248 0469-0687 58.6 µM -0.443222777250265 0.316865806707093 no 2320 0.328802302699756 3253 4017482
SGTC_2082 5219693 150 µM -0.443685021551766 0.316689346040062 no 2321 0.32863516311141 3187 2834649
SGTC_2321 7390090 138.78 µM -0.444269846246534 0.316466150362544 no 2322 0.328423749679415 3197 649046
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.444726017945263 0.316292100901124 no 2323 0.328258882277682 3186 4174840
SGTC_1103 duloxetine 36.1 µM -0.44573209401304 0.315908382737663 no 2324 0.327895389314335 3318 60835 A selective serotonin reuptake inhibitor.
SGTC_934 2950-0684 338 µM -0.446239292143202 0.315715012140265 no 2325 0.327712201569404 3350 1121253
SGTC_3170 9103054 49.47 µM -0.446968613790094 0.315437044788497 no 2326 0.327448860836789 3253 16432970
SGTC_556 4058-0063 51.5 µM -0.447479864356068 0.315242253405026 no 2327 0.32726431155967 3242 6615692
SGTC_2805 7950783 58.44 µM -0.447866327688534 0.315095041235333 no 2328 0.327124835516331 3273 1178958 YDL195W SEC31
SGTC_2847 9005661 71.43 µM -0.449110015719034 0.31462149318212 no 2329 0.32667614783533 3260 2991449
SGTC_776 4476-4378 112 µM -0.449868630545742 0.314332791734017 no 2330 0.326402583918054 3268 2892008
SGTC_3173 9105693 49.47 µM -0.44987202248521 0.314331501138991 no 2331 0.32640136096107 3360 17096658
SGTC_3211 9128781 49.47 µM -0.451244801793145 0.313809360448393 no 2332 0.325906561466731 3232 17194361
SGTC_395 anisomycin 6.25 µM -0.452407122643975 0.313367559532667 no 2333 0.325487858360938 3255 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3349 9149703 23.001 µM -0.452657170283724 0.313272550795976 no 2334 0.325397812396887 3239 4910494
SGTC_485 niflumic acid 177 µM -0.452668546166065 0.313268228681482 no 2335 0.325393716010708 3310 4488 A COX2 inhibitor.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.453562084884893 0.312928820754506 no 2336 0.325072024075922 3132 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3066 9117245 49.47 µM -0.454357837324412 0.312626690053559 no 2337 0.324785646895519 3211 17176980
SGTC_713 1488-1073 324 µM -0.454810458117602 0.312454895467529 no 2338 0.324622802883662 3271 3312542
SGTC_2952 9073731 13.78 µM -0.455725564526206 0.312107686564353 no 2339 0.324293668111031 3202 16457353
SGTC_1587 estradiol valerate 56.1 µM -0.455904037579783 0.312039989901706 no 2340 0.324229492995386 3336 13791 A steroid.
SGTC_1881 5652484 16 µM -0.456516912077872 0.311807568644383 no 2341 0.324009156117836 3305 2255129
SGTC_3202 9113761 49.47 µM -0.456756813825381 0.311716610768237 no 2342 0.323922924896658 3316 4798415
SGTC_2353 9059630 146.67 µM -0.45817146684879 0.311180483909704 no 2343 0.323414628747814 3290 4779114
SGTC_1732 st034308 51.822 µM -0.458217436580469 0.311163068957235 no 2344 0.323398116976131 3089 830119
SGTC_3126 9127922 49.47 µM -0.458944917718614 0.310887529794793 no 2345 0.323136860870688 3383 45595682
SGTC_482 fipronil 114 µM -0.45921611829969 0.310784837572227 no 2346 0.323039488480512 3269 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3233 9132340 49.47 µM -0.459387807054614 0.310719833899012 no 2347 0.322977851280008 3218 17682950
SGTC_3261 9137475 49.47 µM -0.459914383896258 0.310520501674613 no 2348 0.32278883764377 3214 17027690
SGTC_948 3448-0295 75.3 µM -0.46177374007039 0.30981709982112 no 2349 0.322121792121777 3274 678569
SGTC_338 4055-0136 114 µM -0.462695163292196 0.309468779388358 no 2350 0.32179144283161 3194 2900563
SGTC_1804 st050076 49.1 µM -0.462867830572186 0.30940352597502 no 2351 0.321729553698141 3307 3895976
SGTC_3265 9137266 49.47 µM -0.464236108750305 0.308886646884596 no 2352 0.32123929676092 3262 17224265
SGTC_2226 7298446 200 µM -0.464814019561167 0.308668449560364 no 2353 0.321032323577006 3303 3283010
SGTC_2372 9071633 200 µM -0.464816657765085 0.308667453628873 no 2354 0.321031378857137 3339 21321366
SGTC_2551 apiole 73.87 µM -0.465979541308114 0.308228598013487 no 2355 0.320615072368859 3231 10659 A possible DNA adduct former.
SGTC_777 1315-0167 517 µM -0.46732262193655 0.307722079543223 no 2356 0.320134536909347 3274 4221767
SGTC_137 0438-0332 85.389 µM -0.467489372309572 0.307659218208283 no 2357 0.320074896986001 3330 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.470447122976617 0.30654514900551 no 2358 0.31901780191875 3208 2724 A muscle relaxant with antifungal properties.
SGTC_3027 9089541 49.47 µM -0.471521451850425 0.3061409327207 no 2359 0.318634202137772 3322 9943819
SGTC_966 1300-0360 30.2 µM -0.472545450219238 0.305755872849472 no 2360 0.318268754189728 3217 70588
SGTC_3192 9110362 49.47 µM -0.472748554425323 0.305679523929211 no 2361 0.318196290685232 3348 16649480
SGTC_2696 st077691 74.316 µM -0.472914063858856 0.305617313509399 no 2362 0.318137245385827 3350 757133
SGTC_1206 3978-0017 132 µM -0.473539044622347 0.305382451127234 no 2363 0.317914325903782 3443 3873677
SGTC_413 propylparaben 100 µM -0.473664117369056 0.305335459481441 no 2364 0.31786972260682 3224 7175 A pharmaceutical preservative.
SGTC_1624 st003710 6.25 µM -0.474233285986051 0.305121655095938 no 2365 0.317666779739059 3319 24207033
SGTC_2477 5967686 25.23 µM -0.474971330812601 0.304844512506153 no 2366 0.317403703903964 3187 776118
SGTC_3140 9094243 49.47 µM -0.475247937286643 0.304740673070038 no 2367 0.317305131365634 3354 19291112
SGTC_1120 ficusin 1.78878 µM -0.475505978451265 0.304643817322536 no 2368 0.317213186513536 3345 6199 A DNA cross-linker.
SGTC_1075 aripiprazole 15.2 µM -0.475510540315828 0.304642105149898 no 2369 0.317211561138062 3246 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2240 6690706 185.951 µM -0.475545183558889 0.304629102884064 no 2370 0.317199217993729 3131 805876
SGTC_2314 7727897 200 µM -0.475985294601297 0.304463942357048 no 2371 0.317042427223418 3223 900724
SGTC_2452 5863136 48.41 µM -0.476474806902605 0.304280289840161 no 2372 0.316868075698312 3224 2184096
SGTC_3030 9087619 49.47 µM -0.477922132683823 0.303737578973303 no 2373 0.316352813933146 3264 25236973
SGTC_3258 9138477 49.47 µM -0.478256113915033 0.303612405753679 no 2374 0.316233963997098 3289 4970355
SGTC_3097 9117246 49.47 µM -0.478311229735995 0.303591751044264 no 2375 0.316214352408666 3352 16423892
SGTC_741 4582-0002 126 µM -0.478809990249924 0.303404868574017 no 2376 0.316036904449411 3228 2912688
SGTC_1612 st002233 45.4 µM -0.479979366897 0.302966912066866 no 2377 0.315621032291829 3346 1035021
SGTC_1014 4130-3005 69.3 µM -0.480468887924563 0.302783660042628 no 2378 0.315447010371337 3214 743608
SGTC_1216 1165-0504 9.65 µM -0.480671541831927 0.302707811155249 no 2379 0.315374980044674 3366 6304004
SGTC_2584 androsterone 48.74 µM -0.481734804165856 0.302309995080147 no 2380 0.314997174240503 3337 2754130 A steroid.
SGTC_1867 st057372 64 µM -0.482599183726363 0.30198676328625 no 2381 0.314690179407648 3326 688837
SGTC_1313 1220-0047 237 µM -0.484111977551106 0.301421433112802 no 2382 0.314153200658534 3302 3528706
SGTC_650 1328-0195 38 µM -0.485356892506352 0.300956566739205 no 2383 0.313711602564605 3336 2780821
SGTC_3306 9127676 59.7925 µM -0.487749700373195 0.300063972258116 no 2384 0.31286357170634 3317 41905287
SGTC_1407 3909-7909 12.3 µM -0.487979541903243 0.299978297031953 no 2385 0.312782165982131 3308 4411780
SGTC_1751 st044839 27.194 µM -0.488505020787426 0.29978246226804 no 2386 0.312596085142203 3355 5291326
SGTC_355 1311-2252 105 µM -0.488713208849092 0.299704891036134 no 2387 0.312522375483442 3260 5338538
SGTC_2826 7992541 19.48 µM -0.489608933428156 0.299371246268218 no 2388 0.312205326862371 3350 2985066
SGTC_6 0844-0013 19.835 µM -0.49128587925267 0.298747060940251 no 2389 0.311612132856834 3393 1584900
SGTC_785 1270-0111 65.3 µM -0.491300862386937 0.298741486651704 no 2390 0.311606835001604 3275 6741994
SGTC_2182 6325192 200 µM -0.492686267038828 0.298226268529097 no 2391 0.311117141290785 3349 736248
SGTC_391 gliotoxin 8.33 µM -0.49291330303886 0.29814187471778 no 2392 0.311036923586158 3415 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_283 0987-0079 11.7 µM -0.493063494930037 0.298086051374752 no 2393 0.310983861830498 3363 411556
SGTC_1160 4092-0570 10.5 µM -0.495094113494438 0.297331778718134 no 2394 0.310266844406405 3273 4994975
SGTC_617 3770-0098 35 µM -0.497055146146232 0.296604182516709 no 2395 0.309575081826962 3293 5962639
SGTC_902 1120-0002 2.07 µM -0.498047548411185 0.296236285482846 no 2396 0.309225264428926 3345 3280475
SGTC_3088 9117578 49.47 µM -0.498335391406821 0.296129617335836 no 2397 0.309123833377506 3398 678341
SGTC_3062 9077494 49.47 µM -0.499972018818419 0.295523455248786 no 2398 0.308547389998735 3356 16459633
SGTC_2304 7443016 91.4 µM -0.500277346665426 0.29541043333558 no 2399 0.308439901352855 3315 939854
SGTC_3127 9126946 49.47 µM -0.500661145453759 0.295268392380866 no 2400 0.308304810821595 3299 27243249
SGTC_524 r073-0010 27.8 µM -0.503141021603915 0.294351368136732 no 2401 0.307432563661051 3254 2772106
SGTC_2813 7971799 71.43 µM -0.503526601447462 0.294208904206808 no 2402 0.307297041213976 3356 2234054
SGTC_977 1348-1378 135 µM -0.506785002028934 0.293006265364386 no 2403 0.306152840415051 3286 X977
SGTC_1086 cerivastatin 2.18 µM -0.507375080675643 0.292788718157083 no 2404 0.305945833499871 3355 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3313 9133968 57.047 µM -0.507596559688613 0.292707083757471 no 2405 0.305868151903696 3364 1494643
SGTC_1342 1486-1464 234 µM -0.50868415294359 0.292306363953772 no 2406 0.305486815997462 3310 3253938
SGTC_2520 obtusaquinone 4.71 µM -0.509045992500387 0.292173102063044 no 2407 0.305359993236094 3453 5967872
SGTC_164 4100-3994 89.624 µM -0.510109207227607 0.291781694372142 no 2408 0.304987477557964 3446 4615967
SGTC_2973 9094665 17.96 µM -0.510113706797124 0.29178003843759 no 2409 0.304985901484907 3434 25237061 YIL048W NEO1
SGTC_1351 1496-0003 46.5 µM -0.511492846878666 0.291272692879772 no 2410 0.304502997971247 3400 3891978
SGTC_877 0771-0151 33.1 µM -0.512789436855031 0.290796090976609 no 2411 0.304049309787321 3338 6166523
SGTC_2090 5301565 104.445 µM -0.513037556329374 0.290704928539183 no 2412 0.303962524967548 3322 2056344
SGTC_654 1124-0271 80.9 µM -0.51350997492825 0.290531392543065 no 2413 0.303797317521123 3306 5403748
SGTC_594 1487-1584 10.8 µM -0.514875728487093 0.290029975995078 no 2414 0.303319931287041 3285 5013332
SGTC_1194 1488-0194 225 µM -0.515047198334998 0.289967052009249 no 2415 0.303260019321207 3283 1391452
SGTC_2723 salbutamol 83.58 µM -0.515401242826382 0.289837149187431 no 2416 0.30313633208986 3367 9884233 β2-adrenoceptor agonist
SGTC_888 0916-0002 6.97 µM -0.51565312318565 0.289744748132979 no 2417 0.303048350152458 3437 2802138 YIL048W NEO1
SGTC_2645 abamectin 100 µM -0.51568602396516 0.289732679666752 no 2418 0.303036858737134 3372 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1680 diphenhydramine 100 µM -0.517049428103703 0.289232771508094 no 2419 0.302560827493421 3302 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_42 0133-0086 60.653 µM -0.517794888864088 0.288959611114423 no 2420 0.302300692395796 3293 162923 Model of phenazepam hydroxylation.
SGTC_2565 isoliquiritigenin 100 µM -0.518051828941096 0.288865488282457 no 2421 0.302211054152067 3368 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1207 2099-0101 141 µM -0.518841652273069 0.288576248920613 no 2422 0.301935584566191 3379 5837381
SGTC_2149 5554786 194.827 µM -0.520741188116491 0.287881183573594 no 2423 0.301273538831496 3324 745063 YPR165W RHO1
SGTC_1455 4262-0120 131 µM -0.521978714188001 0.287428782109708 no 2424 0.300842575554148 3481 1529587
SGTC_2748 diazoxide 86.69 µM -0.522314366313885 0.287306136012017 no 2425 0.300725734062663 3340 3019 A potassium channel activatior.
SGTC_1298 1079-1278 263 µM -0.52312978544181 0.287008287945584 no 2426 0.300441969607502 3389 2840950
SGTC_166 k072-0058 166.424 µM -0.52315043053881 0.287000748811661 no 2427 0.300434786719446 3436 5846229
SGTC_1268 0828-0275 2.46 µM -0.523243074876229 0.286966918298676 no 2428 0.300402554650776 3397 745337
SGTC_198 3454-2873 16.191 µM -0.523617419500312 0.286830239809723 no 2429 0.300272331609997 3327 710957
SGTC_245 methotrexate 289.6 µM -0.525468718443477 0.286154758492338 no 2430 0.299628696831684 3375 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3121 9125696 49.47 µM -0.525552141887808 0.286124337676853 no 2431 0.299599708011713 3400 1235365
SGTC_2091 4-phenylthiadiazole 200 µM -0.526532814787699 0.285766845172065 no 2432 0.299259029223982 3312 270010
SGTC_285 1486-1325 46 µM -0.527813641565388 0.285300255369029 no 2433 0.298814343995721 3428 22310230
SGTC_1335 1486-0900 202 µM -0.52910559527524 0.2848299801399 no 2434 0.298366100102885 3407 X1335
SGTC_826 1683-5028 118 µM -0.529539497503772 0.28467212136878 no 2435 0.298215626223394 3404 722377
SGTC_2982 9019404 25.97 µM -0.530252998079907 0.284412632250018 no 2436 0.297968265007908 3302 22333232
SGTC_2195 6536160 144.242 µM -0.530517261164 0.284316552544501 no 2437 0.297876672231404 3298 3834386
SGTC_2005 4024620 188 µM -0.530893700664064 0.28417971498487 no 2438 0.297746221625963 3412 236743
SGTC_2316 5844804 197.44 µM -0.530907174028738 0.284174817936128 no 2439 0.297741553075739 3389 776813
SGTC_259 usnic acid 108.925 µM -0.531044188333423 0.28412502080925 no 2440 0.297694079217182 3485 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.532183672232739 0.283711043153276 no 2441 0.297299395210552 3326 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2624 nerol 100 µM -0.532689502140451 0.283527366371588 no 2442 0.297124267135886 3375 637566 A natural product oil.
SGTC_290 2043-6722 48.1 µM -0.533419660542694 0.283262332044009 no 2443 0.296871555424705 3415 773758 YLR208W SEC13
SGTC_3224 9130643 49.47 µM -0.534101223965558 0.283015044095248 no 2444 0.296635751493785 3485 17644395
SGTC_2786 7743617 45.45 µM -0.53483020423401 0.282750666898654 no 2445 0.296383637506371 3320 583674
SGTC_1367 1812-0510 76.9 µM -0.535232433068169 0.282604842528179 no 2446 0.296244570848406 3368 1142582 YDR527W RBA50
SGTC_1021 4476-0760 85.3 µM -0.535385553721359 0.282549339543124 no 2447 0.296191638756858 3318 746768
SGTC_2385 9074692 200 µM -0.536497743437269 0.282146351745259 no 2448 0.295807297528772 3357 17046906
SGTC_1432 4049-0298 68.4 µM -0.53733921961949 0.281841637535787 no 2449 0.295516659551836 3420 741646
SGTC_1882 5615643 20 µM -0.538052865993024 0.281583337222693 no 2450 0.295270275747838 3387 2253075
SGTC_930 2810-3379 265 µM -0.538379677205605 0.281465087858372 no 2451 0.295157476941291 3505 1015764
SGTC_2416 tofa 880 nM -0.538503530637317 0.281420280511757 no 2452 0.295114734145995 3288 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.538782210701511 0.281319473008661 no 2453 0.295018569883785 3320 688667
SGTC_1144 3486-0183 12.5 µM -0.540893441291197 0.280556340064262 no 2454 0.294290515920869 3371 6744069
SGTC_2766 oltipraz 83.91 µM -0.541133089786715 0.280469779215371 no 2455 0.294207926050676 3449 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_852 0418-0143 439 µM -0.54123012953527 0.280434732211789 no 2456 0.29417448636553 3452 5369229
SGTC_1227 3909-8010 46.6 µM -0.542046404820311 0.280140009108316 no 2457 0.293893269229187 3336 15982272
SGTC_817 1391-0715 46 µM -0.542099154205101 0.280120968660563 no 2458 0.293875100678283 3358 1353946
SGTC_1409 3909-8004 61.9 µM -0.542869497876802 0.279842976452995 no 2459 0.293609829247337 3387 2119279
SGTC_71 0417-1750 47.813 µM -0.543541775885133 0.279600482382194 no 2460 0.293378417812508 3450 6811472
SGTC_2883 9059145 45.46 µM -0.544604401001287 0.279217396303619 no 2461 0.293012813614826 3330 16476510
SGTC_2131 toluylene red 5.2905 µM -0.545671673902862 0.278832891621231 no 2462 0.292645823219331 3362 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_655 k060-0012 42 µM -0.546018139330552 0.278708126506196 no 2463 0.292526734212499 3352 5994525
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.549671233233118 0.277394273278842 no 2464 0.291272445523059 3468 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1215 3852-0577 11.2 µM -0.549924676325487 0.277303233670214 no 2465 0.291185519114721 3484 2884876
SGTC_2534 helenine 20.12 µM -0.551359243192198 0.276788196729476 no 2466 0.290693717029028 3424 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3023 9089636 49.47 µM -0.55221149807401 0.276482442968226 no 2467 0.290401728786171 3520 17249241
SGTC_1439 4092-1168 46 µM -0.552213564695021 0.276481701751509 no 2468 0.290401020914857 3415 2886240
SGTC_1129 3453-1384 223 µM -0.553530420534788 0.276009594909372 no 2469 0.289950127973294 3501 1084452
SGTC_2413 inermin 26.06 µM -0.554003323771179 0.275840150725257 no 2470 0.289788285515498 3537 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3016 9080866 49.47 µM -0.554156507738358 0.275785274914175 no 2471 0.289735870202126 3379 17066299
SGTC_3242 9133940 49.47 µM -0.555222113524768 0.275403686489581 no 2472 0.289371372572503 3496 17248444
SGTC_78 0336-0123 156.75 µM -0.557654752876617 0.274533544404313 no 2473 0.288540080227926 3246 6765896
SGTC_2116 5511452 16.8835 µM -0.558698228759445 0.27416071481045 no 2474 0.288183844185182 3468 870744
SGTC_2414 st077232 92.9 µM -0.559396127350754 0.273911498198386 no 2475 0.287945701886947 3291 729801
SGTC_2456 5770359 74.46 µM -0.559866674792979 0.273743530945274 no 2476 0.28778519054675 3476 3118787
SGTC_2750 bromebric acid 70.15 µM -0.560211918591345 0.273620324661201 no 2477 0.287667449194822 3468 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_749 1000-0129 128 µM -0.560438524645184 0.273539471247758 no 2478 0.287590180232504 3507 708470
SGTC_1749 st037932 54.2 µM -0.560539935575642 0.273503291491039 no 2479 0.287555603940025 3459 594497
SGTC_2597 laccaic acid a 100 µM -0.560891185183562 0.27337799663222 no 2480 0.287435859764336 3423 5491415 A textile dye.
SGTC_2030 5175110 200 µM -0.564730980692165 0.272010153041539 no 2481 0.28612837926585 3503 2831986
SGTC_516 3992-2719 87.3 µM -0.565010086146425 0.271910860644531 no 2482 0.286033451922942 3305 5350887 YDR037W KRS1
SGTC_1978 st071761 42 µM -0.565033289823888 0.271902606695623 no 2483 0.286025560728658 3379 5147680
SGTC_1049 3226-0134 66 µM -0.565041890282348 0.271899547395641 no 2484 0.286022635878536 3474 5702385
SGTC_1316 1272-0050 65.9 µM -0.567813388708168 0.27091458052554 no 2485 0.28508084381119 3473 7340392
SGTC_408 cantharidin 100 µM -0.569808237837675 0.270206731847509 no 2486 0.284403883811752 3411 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2132 5317594 122.667 µM -0.569879507277023 0.270181459850484 no 2487 0.284379712461402 3413 794577
SGTC_2697 mebhydrolin 72.4 µM -0.572132028061585 0.269383330225538 no 2488 0.283616266192297 3512 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2288 7946289 167.31 µM -0.572400735848965 0.269288198695371 no 2489 0.283525258725514 3520 1246052
SGTC_995 3931-2021 34.6 µM -0.572700406411411 0.269182125184956 no 2490 0.283423781120679 3440 730143
SGTC_3351 9150312 21.596 µM -0.572843967161029 0.269131316834551 no 2491 0.283375173235455 3441 4904905
SGTC_490 phenamil 164 µM -0.573114274465546 0.269035663996557 no 2492 0.283283661391598 3414 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_620 0109-0052 432 µM -0.574658044979328 0.268489701742398 no 2493 0.282761293649511 3507 493037
SGTC_3111 9122088 49.47 µM -0.574845489438243 0.268423449002566 no 2494 0.282697899330541 3385 16876704
SGTC_2702 st077768 96.8 µM -0.57511558313685 0.268327998129576 no 2495 0.282606564785283 3433 6484119
SGTC_1966 st070145 16.1 µM -0.576039965360975 0.268001451528199 no 2496 0.282294084242401 3407 3748532
SGTC_458 nppb 133 µM -0.576087351267858 0.267984717409627 no 2497 0.282278070269317 3553 4549 A chloride channel blocker.
SGTC_1684 st024538 14.6195 µM -0.576602773817401 0.267802732259858 no 2498 0.282103912485364 3410 6732859
SGTC_2445 5742597 35.57 µM -0.577583655463615 0.267456575106758 no 2499 0.281772622209609 3374 1774255
SGTC_2114 5491910 81.25 µM -0.578590882080132 0.267101355686245 no 2500 0.281432629252803 3512 2849228
SGTC_1969 st069479 40.1 µM -0.580112426089487 0.266565203598515 no 2501 0.28091940231201 3499 3895485
SGTC_2860 9025725 38.96 µM -0.580428357875361 0.26645394582075 no 2502 0.280812893159243 3366 40546248
SGTC_2087 5276107 200 µM -0.58044264439382 0.266448915269973 no 2503 0.280808077248817 3473 144405
SGTC_1157 4092-0394 27.6 µM -0.580788855741735 0.266327022460357 no 2504 0.280691383431386 3579 3659885
SGTC_823 0417-1665 178 µM -0.581011234012553 0.26624874322892 no 2505 0.280616441101057 3481 3429856
SGTC_2635 hydroquinidine 100 µM -0.582070127298754 0.26587616271506 no 2506 0.280259722861113 3469 442912 An experimental heart treatment.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.583248221066248 0.265461951232224 no 2507 0.279863106871536 3400 88881 An O-methylated flavonoid and antioxidant.
SGTC_1574 spiramycin 23.7 µM -0.585583855633332 0.264641723733837 no 2508 0.279077600035395 3477 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2531 methyl deoxycholate 70.07 µM -0.586000572361739 0.264495516898139 no 2509 0.278937565106214 3403 16667744 Haematoxylin.
SGTC_2232 chlorophetanol 41.5365 µM -0.586185010481898 0.264430819124131 no 2510 0.278875596797727 3525 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1759 st043059 70 µM -0.587541927357653 0.26395508336592 no 2511 0.278419900099389 3406 669426
SGTC_474 dl-dihydrosphingosine 5 µM -0.588518030062306 0.263613131228726 no 2512 0.27809231770022 3546 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1953 st076800 12.1 µM -0.590704593234116 0.262847946915609 no 2513 0.27735918490691 3431 297591
SGTC_2334 9017922 200 µM -0.591003859119679 0.262743307726702 no 2514 0.277258917615552 3480 3163164
SGTC_219 mitoxanthrone 164.414 µM -0.591821044446649 0.26245768507072 no 2515 0.276985214770117 3461 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2687 chenodiol 100 µM -0.591992401127012 0.262397812642821 no 2516 0.276927838436271 3516 5702181 A cholesterol synthesis inhibitor.
SGTC_630 4356-0227 183 µM -0.592387216386545 0.262259889886422 no 2517 0.276795662347968 3509 779312
SGTC_2465 5809242 33.21 µM -0.59396205094651 0.261710114920305 no 2518 0.276268747566087 3495 2731748
SGTC_3345 9148410 3.559 µM -0.594857738060131 0.261397694437235 no 2519 0.275969284517698 3508 4903596
SGTC_2908 7930301 100 µM -0.595110376301448 0.261309607504586 no 2520 0.275884846559668 3436 2223178
SGTC_205 1486-1330 71.903 µM -0.597920356819606 0.26033088557838 no 2521 0.274946538053414 3500 4118834
SGTC_2320 7373003 200 µM -0.598332380674069 0.260187535755237 no 2522 0.274809087377433 3500 5415828
SGTC_2995 9067767 71.4286 µM -0.598577612407035 0.26010223495028 no 2523 0.274727294441173 3442 11673567
SGTC_2936 9038235 15.59 µM -0.599661604010703 0.259725354750649 no 2524 0.274365891065299 3525 4749415
SGTC_2934 9036370 36.88 µM -0.599866757271276 0.259654059174036 no 2525 0.27429751928014 3479 6462800
SGTC_2920 7982904 15.77 µM -0.599916065076914 0.259636925059436 no 2526 0.274281087635744 3481 6456808
SGTC_1015 4130-4525 82 µM -0.601264314592677 0.259168644145363 no 2527 0.273831976890774 3429 1363237
SGTC_1169 aniline yellow 25.8 µM -0.601867246676899 0.258959372060938 no 2528 0.273631253996085 3473 6051 A DNA damaging agent.
SGTC_2806 7952793 58.44 µM -0.601897014232641 0.258949042285575 no 2529 0.273621345927 3522 2972490
SGTC_2818 7996756 12.99 µM -0.602249308488181 0.258826807238111 no 2530 0.273504099000085 3482 2241621
SGTC_2175 5807670 165.306 µM -0.602405442119386 0.258772643319456 no 2531 0.273452144175475 3498 241186
SGTC_2602 kawain 100 µM -0.603364905475064 0.258439927171462 no 2532 0.273132981700314 3528 5369129
SGTC_160 3453-0671 289.699 µM -0.604474560020125 0.258055405293892 no 2533 0.272764088955399 3471 5322268
SGTC_2956 9076196 2.52 µM -0.605141749892367 0.257824350935799 no 2534 0.272542407897148 3582 16423868
SGTC_534 k292-0788 63.4 µM -0.605186346936589 0.257808910373499 no 2535 0.272527593236308 3577 4146317
SGTC_1622 st003707 19.4 µM -0.605856819139839 0.257576834731942 no 2536 0.272304917747098 3529 10140899
SGTC_793 0488-0545 106 µM -0.606035941801973 0.257514852012564 no 2537 0.272245443298059 3421 292548
SGTC_963 1269-2853 151 µM -0.608049182992097 0.256818733255852 no 2538 0.271577427209052 3489 3668223
SGTC_2674 ligustilide 100 µM -0.609294968349877 0.256388468891981 no 2539 0.271164470817584 3509 5319022 A signalling regulator.
SGTC_1323 1348-1351 11.2 µM -0.610327539369203 0.256032128565031 no 2540 0.270822428774486 3456 6989654
SGTC_1151 3909-8316 15.3 µM -0.610611124773464 0.255934308463222 no 2541 0.270728528022984 3552 800431
SGTC_706 4262-0057 46.9 µM -0.610661453655472 0.25591695002943 no 2542 0.270711864830648 3512 883298
SGTC_577 r071-0003 38.6 µM -0.611759568602372 0.255538363123014 no 2543 0.270348421787361 3552 4568517 YMR134W ERG29
SGTC_2043 5101342 149 µM -0.61249367659288 0.255285434786454 no 2544 0.270105590212483 3476 678451
SGTC_229 benomyl 22.8748 µM -0.613971351071531 0.254776716421667 no 2545 0.269617129430961 3544 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2821 7996764 71.43 µM -0.61432925628799 0.254653580434126 no 2546 0.269498886723072 3631 2987135
SGTC_1274 0865-0114 173 µM -0.615509840479757 0.254247625813129 no 2547 0.269109036322248 3505 870624
SGTC_760 0568-0725 82.9 µM -0.616773640258657 0.253813433082784 no 2548 0.268692020458853 3553 3916171
SGTC_2017 5132927 60.65 µM -0.616878237208305 0.253777515065475 no 2549 0.268657521169123 3493 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2639 lactacystin 53 µM -0.618410696538696 0.253251583076413 no 2550 0.268152324300624 3564 3870 A proteasome inhibitor.
SGTC_1454 4239-0054 42.6 µM -0.618715022795272 0.253147208152085 no 2551 0.268052055779641 3642 1340767
SGTC_3187 9109394 49.47 µM -0.619796369261921 0.252776521331536 no 2552 0.267695929673022 3499 17098090
SGTC_1006 4099-6547 255 µM -0.62031377818587 0.252599254096086 no 2553 0.267525612771217 3556 3146833
SGTC_997 3996-0078 137 µM -0.621179608219891 0.252302762353725 no 2554 0.26724072741434 3541 735687
SGTC_1332 1480-0653 17.5 µM -0.623061691171512 0.251658902028091 no 2555 0.266621991393885 3538 5749438
SGTC_3014 9081533 49.47 µM -0.623141138686404 0.251631742146752 no 2556 0.266595888912198 3560 21367265
SGTC_150 3970-0969 77.2 µM -0.623390480481848 0.251546512361114 no 2557 0.266513976055564 3556 6615640
SGTC_372 0155-0182 15.9 µM -0.623775435406818 0.251414957376065 no 2558 0.266387537070572 3539 771486
SGTC_1419 3993-2473 62.6 µM -0.624417227053007 0.251195711559361 no 2559 0.266176807205407 3568 704026
SGTC_3290 9121031 71.43 µM -0.624534519214695 0.251155653698803 no 2560 0.266138303890502 3494 17014854
SGTC_645 0845-0943 5.41 µM -0.624933582649878 0.251019390040013 no 2561 0.266007325083012 3514 1885106
SGTC_3115 9123671 49.47 µM -0.629509187059228 0.249459810067433 no 2562 0.264507878033983 3638 3286988
SGTC_430 0958-0115 16.4 µM -0.630065792675941 0.249270444763947 no 2563 0.264325769607797 3500 6833180
SGTC_1701 st028638 40.4 µM -0.631986103040128 0.248617714487284 no 2564 0.263697979052062 3558 3490878
SGTC_23 0213-0011 39.996 µM -0.632008387817114 0.248610145044599 no 2565 0.263690698148234 3599 627608
SGTC_529 4076-0302 30.3 µM -0.632032628727489 0.248601911303904 no 2566 0.263682778251061 3529 5816522
SGTC_168 3970-0862 530.542 µM -0.633744047563987 0.248020972958621 no 2567 0.263123936911529 3590 3135186
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.633941465587524 0.247954006357868 no 2568 0.263059511601211 3569 688761
SGTC_435 c-PAF 6.7 µM -0.634084914693165 0.247905352725729 no 2569 0.263012703541159 3511 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1753 st043925 64 µM -0.635234758248584 0.247515544477945 no 2570 0.26263765852824 3568 670181
SGTC_2015 5119600 184 µM -0.635419872036861 0.247452819706952 no 2571 0.262577305460723 3570 2828786
SGTC_2666 tannic acid 100 µM -0.636747206318591 0.247003308845514 no 2572 0.262144759668323 3593 16134267 A thiamine antagonist.
SGTC_415 dibenzyl ketone 100 µM -0.637575532072352 0.246723012200841 no 2573 0.261875013703777 3546 7593
SGTC_2077 5212015 200 µM -0.640954870769006 0.245581246857696 no 2574 0.260776002109708 3511 780900
SGTC_695 3505-6186 243 µM -0.641459611176765 0.245410955923186 no 2575 0.26061205688921 3586 1819379
SGTC_1651 st011928 86.1 µM -0.642625653517616 0.245017795577667 no 2576 0.260233516512877 3581 720198
SGTC_2828 7998861 71.43 µM -0.645253828404935 0.24413288464086 no 2577 0.259381354190067 3522 2988188
SGTC_3009 9080819 71.4286 µM -0.645481220202952 0.24405640252835 no 2578 0.259307692242033 3578 17027216
SGTC_3174 9107204 49.47 µM -0.645721165427181 0.243975712148217 no 2579 0.259229975424157 3622 3938802
SGTC_666 0272-0154 136 µM -0.646714678102248 0.243641760307033 no 2580 0.25890831080043 3586 6870312
SGTC_926 2268-1401 59.4 µM -0.649690882713792 0.242642840306579 no 2581 0.257945957174157 3591 2931578
SGTC_363 0455-0021 3.06 µM -0.649702483136478 0.242638951135778 no 2582 0.257942209819701 3620 4597466
SGTC_3008 9078912 71.4286 µM -0.651540211601343 0.242023258626753 no 2583 0.257348914149865 3591 16648731
SGTC_296 1222-0039 74.9 µM -0.652090336597757 0.241839115665754 no 2584 0.257171448795644 3558 5984176
SGTC_2964 9083345 53.42 µM -0.653416255963714 0.241395604186841 no 2585 0.256743980830274 3560 17741579
SGTC_1672 st016598 6.51 µM -0.653964608007157 0.24121231320156 no 2586 0.256567303802327 3548 4665860 YNL267W PIK1
SGTC_3099 9120367 49.47 µM -0.654235943084014 0.241121645299951 no 2587 0.256479904055767 3633 24824940
SGTC_2146 5545642 200 µM -0.654622024086383 0.240992666447802 no 2588 0.25635557023963 3625 825326
SGTC_2896 9052656 71.43 µM -0.654804617496399 0.240931680173557 no 2589 0.256296778663733 3583 6469436
SGTC_3178 9107506 49.47 µM -0.655696248326749 0.240633995725824 no 2590 0.256009791622406 3633 8897194
SGTC_321 4534-3890 65.3 µM -0.65595819847949 0.240546577769341 no 2591 0.255925510237531 3611 699746
SGTC_2406 ethylparaben 405.7 µM -0.6567713378087 0.240275327243782 no 2592 0.255663978258131 3441 8434 A possible steroid mimic.
SGTC_3154 9100113 49.47 µM -0.657074154368765 0.240174354995732 no 2593 0.255566618308892 3577 25237525
SGTC_1996 st072960 66.8 µM -0.659552731337991 0.239348759316621 no 2594 0.254770448175061 3614 1719405
SGTC_3034 9090421 49.47 µM -0.66090469654701 0.238899083913394 no 2595 0.254336716982698 3552 17173761
SGTC_2848 9016370 25.97 µM -0.662734332900401 0.238291267347202 no 2596 0.253750358489614 3634 7894410
SGTC_1451 4152-0210 104 µM -0.663157432686271 0.238150831655389 no 2597 0.253614865365771 3622 659563
SGTC_2731 amoxapine 43.43 µM -0.66320964847033 0.238133503286027 no 2598 0.253598146461219 3649 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_68 0986-0284 82.829 µM -0.664102421631495 0.237837333835534 no 2599 0.253312380170472 3588 423278 YIL048W NEO1
SGTC_2007 4011539 71.82 µM -0.664449595600946 0.237722216574232 no 2600 0.253201299559427 3626 45595301
SGTC_450 aminopyrene 156 nM -0.666832690283549 0.236932846604858 no 2601 0.252439504568847 3589 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1389 3405-0187 19 µM -0.667677734111327 0.236653282971493 no 2602 0.252169662951519 3560 799890
SGTC_1494 4358-1428 177 µM -0.667929831339655 0.236569917462747 no 2603 0.252089192073196 3657 1564571
SGTC_722 3534-0461 190 µM -0.668462172114678 0.236393931897219 no 2604 0.251919310366695 3594 658262
SGTC_1770 st043884 66.3 µM -0.66895158281422 0.236232202112487 no 2605 0.251763181922197 3621 670149
SGTC_530 4358-1714 28 µM -0.669163723049062 0.236162117565727 no 2606 0.251695522275921 3632 1564641
SGTC_1968 st069590 43.6 µM -0.669247509677953 0.236134440220407 no 2607 0.251668802156364 3585 6384066
SGTC_980 1473-0395 201 µM -0.669374271232949 0.236092570309052 no 2608 0.251628379891874 3580 768876
SGTC_1840 st055363 71 µM -0.669417909187596 0.236078157442933 no 2609 0.251614465228613 3571 676033
SGTC_2065 5221596 34.26 µM -0.673535184029376 0.234720475090142 no 2610 0.250303436391316 3622 788581
SGTC_2294 7971431 200 µM -0.675534184334861 0.234062859457447 no 2611 0.249668220235842 3582 5741572
SGTC_3123 9126162 49.47 µM -0.675745976145924 0.233993245661467 no 2612 0.249600970003347 3692 25239884
SGTC_535 2293-4129 48.2 µM -0.675770327464775 0.233985242367934 no 2613 0.249593238348373 3659 396118 YIL048W NEO1
SGTC_644 1498-1197 63.3 µM -0.676904433195526 0.233612675715731 no 2614 0.249233295584836 3664 6741615
SGTC_1295 1013-0063 9.78 µM -0.677121204466068 0.233541501347224 no 2615 0.24916452809979 3640 6826038
SGTC_820 1582-0060 59.9 µM -0.677643506048512 0.233370059000379 no 2616 0.248998877094376 3621 3848840
SGTC_2641 levomentholum 100 µM -0.678979852851596 0.232931729270239 no 2617 0.248575313798059 3608 16666
SGTC_1656 st012921 11 µM -0.67925090779231 0.232842877450077 no 2618 0.248489448123724 3587 6732821
SGTC_761 k216-0224 480 µM -0.679361722892611 0.232806557679423 no 2619 0.248454348304476 3684 1340404
SGTC_2712 st079126 47.7 µM -0.680642544380758 0.232386995565207 no 2620 0.248048849908514 3620 3152970
SGTC_2914 7968218 45.32 µM -0.682368127297222 0.231822407382948 no 2621 0.247503102179647 3603 2977111
SGTC_1973 st070275 50.2 µM -0.682584705663015 0.23175159978008 no 2622 0.247434650582474 3587 17118334
SGTC_830 4076-0286 57.8 µM -0.682924963595425 0.231640381021263 no 2623 0.247327129350279 3693 6866659
SGTC_757 1066-0008 322 µM -0.683386373439427 0.23148960934813 no 2624 0.247181364120984 3656 6842497
SGTC_2365 9042475 200 µM -0.685391777857302 0.230834953406273 no 2625 0.246548365528639 3674 6464479
SGTC_960 1222-0186 7.7 µM -0.685995165291129 0.230638182616136 no 2626 0.246358078579561 3654 3126296
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.686188417246767 0.230575181004756 no 2627 0.246297150429621 3674 66535 A nucleotide analog.
SGTC_3257 9139206 32.98 µM -0.68639950850877 0.230506374634634 no 2628 0.246230607165435 3623 4910041
SGTC_1482 3346-2049 8.48 µM -0.68750185494761 0.230147245193477 no 2629 0.245883266121227 3653 3826804
SGTC_2024 5144227 134 µM -0.690397675260457 0.229205319221896 no 2630 0.244972069140397 3668 3475211
SGTC_2442 5158906 48.48 µM -0.690521295226977 0.229165157418862 no 2631 0.244933211435186 3661 1893835
SGTC_853 0419-0306 21 µM -0.69254906417567 0.228506937016712 no 2632 0.244296292522009 3641 762713
SGTC_3282 9108498 15.4605 µM -0.692658843009947 0.228471332780605 no 2633 0.244261836661732 3643 16459645
SGTC_1375 2910-0797 186 µM -0.692922439073203 0.228385854197472 no 2634 0.24417911347808 3665 742508
SGTC_2274 7947094 46.08 µM -0.693274002928507 0.22827187750767 no 2635 0.244068807265169 3659 2971028
SGTC_625 k213-0058 121 µM -0.693754781660548 0.22811606124114 no 2636 0.243918002281482 3723 3655420
SGTC_2192 5915882 198.485 µM -0.694141941340348 0.22799062959177 no 2637 0.243796599168995 3631 2876149
SGTC_1634 st006576 41 µM -0.694903883589246 0.227743889559838 no 2638 0.243557769365193 3652 3915356
SGTC_1734 st037168 69.4 µM -0.69541659731511 0.227577941920983 no 2639 0.243397131068797 3680 708907
SGTC_1735 st034310 56.75 µM -0.695547855377572 0.227535469190835 no 2640 0.243356015821601 3741 871153
SGTC_396 dithiazanine 1.25 µM -0.695593440876179 0.227520719594067 no 2641 0.243341737507977 3655 10578 An antihelmenthic.
SGTC_2084 5306078 60.6385 µM -0.697356952289094 0.226950533162757 no 2642 0.242789717235149 3622 679340
SGTC_1070 indatraline 8.81 µM -0.697699711884571 0.226839804203015 no 2643 0.242682504194311 3671 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1339 1486-1321 22.7 µM -0.698355623973565 0.226627995884883 no 2644 0.2424774105012 3706 3469382
SGTC_1098 clofazimine 15.1 µM -0.698519429688003 0.226575116872557 no 2645 0.242426205611252 3719 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_578 3460-0051 92 µM -0.69860064211676 0.22654890283014 no 2646 0.242400821163235 3736 2876744
SGTC_172 1112-0046 2.638 µM -0.702529674512366 0.225282722411853 no 2647 0.241174451202356 3628 2802135 YIL048W NEO1
SGTC_1841 st054148 70 µM -0.702553431961632 0.225275078482913 no 2648 0.241167046055464 3668 675442
SGTC_1678 st019265 80.2 µM -0.702956131438259 0.225145532789431 no 2649 0.241041544281961 3700 5367020
SGTC_161 4065-0411 162.148 µM -0.70348064023653 0.22497686516273 no 2650 0.240878133753471 3696 1906281 YLR208W SEC13
SGTC_223 busulfan 5 mM -0.707475277120533 0.223694651658784 no 2651 0.239635585591723 3666 2478 A DNA alkylator.
SGTC_2009 4012297 12.05 µM -0.707502882358717 0.223685805305962 no 2652 0.23962701105803 3677 45595307
SGTC_389 tpck 16.7 µM -0.707689716998165 0.223625937654175 no 2653 0.239568982274858 3687 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2368 9071271 200 µM -0.707728054608992 0.22361365421346 no 2654 0.23955707598341 3687 27209959
SGTC_1752 st044819 83.042 µM -0.707858813037985 0.223571761859562 no 2655 0.239516469519591 3665 441209 YML126C ERG13
SGTC_986 1493-0483 84 µM -0.709886312734004 0.222922763444187 no 2656 0.238887319418676 3628 40079
SGTC_1705 st027868 56.3335 µM -0.710983526195663 0.222571995722809 no 2657 0.238547222176661 3705 292948
SGTC_718 1130-0073 349 µM -0.712099032403214 0.222215702813365 no 2658 0.238201726709388 3735 6740020
SGTC_2264 7948757 110.76 µM -0.7124973886094 0.222088546669877 no 2659 0.238078413974497 3679 2971411
SGTC_2055 5235184 200 µM -0.713256028497535 0.221846502116207 no 2660 0.237843670795003 3704 2836034
SGTC_279 1273-0055 2.93 µM -0.714780792492303 0.221360481173719 no 2661 0.237372252785727 3734 2847562
SGTC_1106 tegaserod maleate 11.7 µM -0.717461455441886 0.220507493535705 no 2662 0.236544705704814 3741 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1646 st011709 75.6 µM -0.717508988802466 0.220492385422988 no 2663 0.236530046026732 3667 5757843
SGTC_1094 duloxetine 25.4 µM -0.718955210103573 0.220032998783677 no 2664 0.236084258614181 3707 60834 A selective serotonin reuptake inhibitor.
SGTC_1972 st070201 17.4 µM -0.720142181554718 0.219656372479437 no 2665 0.235718729248909 3680 2829099
SGTC_273 hydroxyurea 18.1 mM -0.720198301596669 0.219638574747344 no 2666 0.235701454741043 3756 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1197 1601-0112 267 µM -0.720434752772334 0.219563596466958 no 2667 0.23562867953963 3708 7350313
SGTC_1642 st009582 77.7 µM -0.721029136118471 0.219375183420449 no 2668 0.235445794333534 3704 6739311
SGTC_1450 4112-4260 37.6 µM -0.721166077041487 0.219331787811203 no 2669 0.235403670226044 3687 1633175
SGTC_1019 4262-0212 3.4 µM -0.721195258413673 0.219322541078569 no 2670 0.235394694343564 3754 4677213
SGTC_631 k072-0230 41.5 µM -0.72159759865176 0.219195073937097 no 2671 0.235270957985926 3729 5773147
SGTC_1865 st057639 52.2 µM -0.722897978594775 0.218783386353174 no 2672 0.234871282767399 3705 688818
SGTC_310 1273-0058 1.06 µM -0.72381506165074 0.218493314562008 no 2673 0.234589640653806 3702 2734232
SGTC_324 1315-0088 19.6 µM -0.724223414558385 0.218364224535198 no 2674 0.234464292975196 3653 6787421
SGTC_2099 5377090 177.372 µM -0.725411014396458 0.217989045871548 no 2675 0.234099958968307 3714 2243829
SGTC_2425 5628681 7.85 µM -0.725721078187755 0.217891153792725 no 2676 0.234004888681818 3755 5714958
SGTC_2545 solidagenone 89.61 µM -0.726970561176329 0.217496929118955 no 2677 0.233621994965809 3546 6708572 An anti ulcer agent
SGTC_1357 1503-1303 39.5 µM -0.727474479852888 0.217338054198951 no 2678 0.233467671617791 3721 292895
SGTC_90 0870-0863 4.608 µM -0.727549729142764 0.217314335438726 no 2679 0.233444631636996 3705 1738164
SGTC_2153 5569715 200 µM -0.728000296963192 0.217172346635048 no 2680 0.233306702253759 3734 2054701
SGTC_1232 0279-0259 161 µM -0.729172299723209 0.216803260965013 no 2681 0.232948136603554 3744 1560000
SGTC_1211 1056-0033 32.3 µM -0.730134661150029 0.21650046664519 no 2682 0.232653938185319 3724 6741922
SGTC_2243 6634756 200 µM -0.731215625227401 0.216160647532855 no 2683 0.232323728802109 3758 885676
SGTC_2867 9039098 71.43 µM -0.732453514790282 0.215771875927094 no 2684 0.231945902806181 3708 6463460
SGTC_416 estradiol valerate 100 µM -0.73280747362503 0.215660786169828 no 2685 0.231837931191645 3750 13791 A steroid.
SGTC_2463 5473429 200 µM -0.732958808294243 0.215613300000822 no 2686 0.231791776604431 3725 5399405
SGTC_140 0062-0056 502.533 µM -0.733702072797547 0.215380164645997 no 2687 0.231565167468847 3714 3758964
SGTC_1388 3346-4487 254 µM -0.733821141759761 0.215342830588942 no 2688 0.231528876777995 3784 3345614
SGTC_294 k038-0071 157 µM -0.739752064135477 0.213487947490176 no 2689 0.229725225149299 3743 24152826
SGTC_640 3381-0960 37.1 µM -0.741038955800986 0.21308670780459 no 2690 0.229334910304381 3774 1745025
SGTC_2071 5230951 39.92 µM -0.744765391966606 0.21192732723401 no 2691 0.228206779945377 3779 1799272
SGTC_129 0088-0017 176.636 µM -0.748942989759692 0.210631977150388 no 2692 0.226945783869941 3634 182446
SGTC_333 3486-0131 40.1 µM -0.749780903794544 0.210372725122241 no 2693 0.226693335866172 3810 6744690
SGTC_1583 clindamycin 39.6 µM -0.750112524087563 0.210270173004534 no 2694 0.226593468591954 3729 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_149 3970-0822 46.1 µM -0.750174344249372 0.210251058638234 no 2695 0.226574854229923 3783 3114250 YBL034C STU1
SGTC_3314 9135860 59.4275 µM -0.75538528927217 0.208643541613457 no 2696 0.225008918625106 3730 25252478
SGTC_2045 5106652 78.05 µM -0.756049109935274 0.20843928205114 no 2697 0.224809875951226 3745 673349
SGTC_96 0929-0093 37.281 µM -0.757282841451208 0.20805997266539 no 2698 0.22444021421949 3736 6991579
SGTC_3038 9091290 49.47 µM -0.759466371524746 0.207389648323417 no 2699 0.22378681160114 3783 25236843
SGTC_1863 st057641 20.1 µM -0.760059606567077 0.207207751230806 no 2700 0.223609478083015 3790 3921635
SGTC_1808 st050063 61.5 µM -0.760314961486975 0.207129483636896 no 2701 0.223533170407296 3747 4011993
SGTC_2924 9010168 62.78 µM -0.761339734080617 0.206815561538604 no 2702 0.223227086788428 3863 2993929
SGTC_2432 5630864 12.22 µM -0.761401820731156 0.206796551375386 no 2703 0.223208550140622 3768 5714970
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.761409891678493 0.20679408022728 no 2704 0.223206140535478 3786 165506
SGTC_1127 asiatic acid 681.4 nM -0.762460666009739 0.20647250535265 no 2705 0.222892555241675 3756 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3036 9090181 49.47 µM -0.762973942227012 0.206315532064448 no 2706 0.222739468185421 3780 25236586
SGTC_1970 st070122 35.8 µM -0.763253558869339 0.206230047752306 no 2707 0.222656096420845 3775 102928
SGTC_1319 1306-0155 43.7 µM -0.764694133284366 0.205789968629275 no 2708 0.222226850230582 3811 3122360
SGTC_250 brefeldin a 552.239 µM -0.765169971190882 0.205644728071142 no 2709 0.222085169208946 3664 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1907 st060210 83.7 µM -0.766068221004907 0.205370720131265 no 2710 0.221817855376205 3785 688793
SGTC_1817 st052116 64.4 µM -0.767282905826151 0.205000529898655 no 2711 0.221456664830172 3767 4361398
SGTC_2234 tolnaftate 200 µM -0.767972540318569 0.204790531901674 no 2712 0.221251749466419 3760 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_507 nimesulide 162 µM -0.768167036247325 0.20473132981738 no 2713 0.221193977300725 3806 4495 A COX2 inhibitor.
SGTC_2281 7943571 200 µM -0.768316836609045 0.204685739435071 no 2714 0.221149487181896 3885 1244024
SGTC_3191 9110352 49.47 µM -0.769051553860894 0.204462222364026 no 2715 0.220931353194421 3746 17122424
SGTC_1044 1222-0021 1.78 µM -0.771177602275336 0.203816250820685 no 2716 0.220300834068375 3802 4306703
SGTC_1085 doxorubicin 7.67 µM -0.772052469858756 0.203550787613661 no 2717 0.220041675757565 3782 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1092 toremifene 6.32 µM -0.772428567457719 0.203436730810385 no 2718 0.219930319739736 3773 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1072 oxiconazole 14.9 nM -0.772683931510461 0.203359309863532 no 2719 0.219854729280758 3785 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_326 k292-0812 17.5 µM -0.773894323470743 0.202992583994176 no 2720 0.219496643372376 3743 3579357
SGTC_412 gemfibrozil 100 µM -0.774457459521267 0.202822099124326 no 2721 0.219330157815902 3751 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2727 riluzole 51.77 µM -0.775972944298966 0.2023637234532 no 2722 0.21888248046413 3803 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2886 9058944 51.95 µM -0.776081879192173 0.202330798734917 no 2723 0.218850321134847 3660 4949929
SGTC_325 2810-4341 181 µM -0.776188263061373 0.202298648136043 no 2724 0.218818917532762 3781 774970
SGTC_1519 esterone 74 µM -0.781667373223746 0.200646923817986 no 2725 0.217205040449146 3804 698 A steroid.
SGTC_1269 0831-0796 3.05 µM -0.782589753708277 0.200369662763416 no 2726 0.2169340301784 3805 927758
SGTC_2595 hexamethylquercetagetin 100 µM -0.782950070311204 0.200261416685072 no 2727 0.216828216457871 3780 386331
SGTC_478 N-arachidonylglycine 10 µM -0.783382939675762 0.200131420828071 no 2728 0.216701135727018 3748 5283389
SGTC_1029 k015-0030 64.7 µM -0.783831694848103 0.199996707833037 no 2729 0.216569436766546 3895 2208316
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.784890208173218 0.19967916597886 no 2730 0.216258971796576 3836 6728940
SGTC_964 1287-0107 19.4 µM -0.786106764261617 0.19931458801921 no 2731 0.215902470892873 3831 51516812 YPR165W RHO1
SGTC_1039 k821-0043 94 µM -0.788178156664958 0.19869475544558 no 2732 0.21529625202377 3772 15992768
SGTC_2710 st078562 53.7235 µM -0.78837581237032 0.198635670800303 no 2733 0.215238457280808 3786 17250908
SGTC_792 4534-1957 155 µM -0.788596591668171 0.198569686416171 no 2734 0.215173911821507 3786 1717904
SGTC_953 1188-0045 9.7 µM -0.789337816992993 0.198348252873717 no 2735 0.214957294674775 3838 6144426
SGTC_1422 4031-0024 15.5 µM -0.789551067485231 0.198284574067044 no 2736 0.214894997399018 3754 782427
SGTC_180 1486-1293 102.781 µM -0.791005942629202 0.197850462613118 no 2737 0.214470261848949 3772 4140536
SGTC_1337 1486-1011 40.3 µM -0.792134191746958 0.197514206760767 no 2738 0.214141217639124 3820 X1337
SGTC_1845 st056753 3.01 µM -0.792365729639233 0.197445243502664 no 2739 0.214073727938188 3788 5375839
SGTC_1922 5578187 25 µM -0.793448371720801 0.197122973234255 no 2740 0.213758318891419 3799 1350412
SGTC_1484 3473-2379 286 µM -0.794487093278571 0.196814076181568 no 2741 0.213455959897001 3933 671917
SGTC_2341 7987486 176.74 µM -0.795431279887392 0.196533546582931 no 2742 0.213181335255744 3847 1258686
SGTC_2912 7964298 10.93 µM -0.796112089542651 0.196331419967376 no 2743 0.212983443947441 3879 2975850
SGTC_10 0279-0212 42.575 µM -0.796277581975876 0.196282305712271 no 2744 0.212935356372274 3816 39851 YBR002C RER2
SGTC_1939 st074455 53.6 µM -0.796499152481475 0.196216560470147 no 2745 0.212870983963968 3809 1644229
SGTC_452 diindolylmethane 8 µM -0.798296534467335 0.19568372810259 no 2746 0.212349214322699 3834 3071 Inhibits expression of several cancer promoting factors.
SGTC_1896 st058441 89 µM -0.799669653942025 0.195277260440368 no 2747 0.211951109690697 3857 688759
SGTC_746 1095-0025 46.6 µM -0.800023554694329 0.195172582761997 no 2748 0.211848575051713 3856 6749286
SGTC_1491 4138-0063 26.5 µM -0.80048660452232 0.195035672199987 no 2749 0.211714460803472 3782 23883227
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.801747943343196 0.194663026706824 no 2750 0.211349388293308 3785 97141
SGTC_282 k297-0036 65.7 µM -0.802168286023493 0.194538938448353 no 2751 0.2112278094049 3820 5061378
SGTC_2957 9076800 11.52 µM -0.802206278010631 0.194527725306298 no 2752 0.211216822715102 3802 16459615
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.803086317426374 0.194268096241406 no 2753 0.210962422770736 3859 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.80345095559896 0.194160582614506 no 2754 0.210857066594168 3845 364106
SGTC_477 mead ethanolamide 10 µM -0.803480105775266 0.194151989244846 no 2755 0.210848645464381 3695 16061185
SGTC_2186 6124449 200 µM -0.803784547059016 0.194062254867973 no 2756 0.210760707884123 3808 3834182 YLR033W RSC58
SGTC_1013 4112-3890 241 µM -0.804297858512599 0.193911013025978 no 2757 0.210612487074625 3796 705171
SGTC_2960 9079389 5.97 µM -0.806200861823417 0.193350940129301 no 2758 0.210063520939582 3825 16457355
SGTC_195 4234-0266 16.654 µM -0.809113161697313 0.192495734707182 no 2759 0.209225029139213 3840 2303354
SGTC_2199 6590217 200 µM -0.811792214171402 0.191711068612021 no 2760 0.208455435186957 3769 703109
SGTC_1011 4112-3381 17.4 µM -0.812379810963338 0.191539230012649 no 2761 0.208286863584375 3943 2877139
SGTC_3167 9103034 49.47 µM -0.812509042787961 0.191501449725618 no 2762 0.208249799946611 3871 5127859
SGTC_783 0848-0141 92.7 µM -0.812641497169409 0.191462732078126 no 2763 0.208211816119111 3822 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1792 st045773 43.6 µM -0.812885167906494 0.191391517384651 no 2764 0.208141949553008 3765 2919270
SGTC_2402 5553605 200 µM -0.813803223667118 0.191123354170439 no 2765 0.207878844026101 3892 6758546
SGTC_659 k018-0002 107 µM -0.814620661410544 0.190884775381883 no 2766 0.207644739979819 3817 6797879 YHR007C ERG11
SGTC_1333 1482-0047 286 µM -0.814748648672645 0.190847437348797 no 2767 0.207608100121714 3811 3811116
SGTC_3011 9081274 71.4286 µM -0.815538781189694 0.190617029317586 no 2768 0.207381987659805 3856 6625322
SGTC_1134 3477-0009 42.5 µM -0.817124369680703 0.190155176318247 no 2769 0.20692867879386 3923 3973534
SGTC_2711 st079103 59.1 µM -0.817137785445367 0.190151271486642 no 2770 0.20692484582236 3824 54693780
SGTC_1992 st073643 23.3 µM -0.817606239002027 0.190014952927304 no 2771 0.20679103193619 3809 3161292
SGTC_2695 st077686 51.995 µM -0.817731594086166 0.189978485169232 no 2772 0.206755232912516 3914 2876092
SGTC_2931 9014674 55.67 µM -0.817965315845208 0.189910503337045 no 2773 0.206688496230145 3871 2996810
SGTC_2049 5262831 67.185 µM -0.81879312517262 0.189669841644592 no 2774 0.206452226983568 3906 763417
SGTC_1025 k007-0731 70 µM -0.819110649689598 0.189577580346863 no 2775 0.206361643182343 3828 6256118
SGTC_2611 pyromycin 23.93 µM -0.823297140729362 0.188363718730538 no 2776 0.205169519608459 3877 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1745 st081495 74 µM -0.823836369563581 0.188207720082915 no 2777 0.205016269635725 3786 13842402 YBL026W LSM2
SGTC_552 k242-0005 476 µM -0.824796958119632 0.18793001983759 no 2778 0.204743436973284 3935 4088318
SGTC_3284 9108171 64.8615 µM -0.825465821966252 0.187736804901256 no 2779 0.204553589481109 3848 8687505
SGTC_538 2922-0838 53.3 µM -0.826359846179043 0.187478739501583 no 2780 0.204299997066839 3855 777039
SGTC_1908 st060353 56.5 µM -0.82663405713764 0.187399630834633 no 2781 0.204222253905332 3903 4227716
SGTC_112 phenothiazine 287.218 µM -0.826789010504849 0.187354936588993 no 2782 0.204178329956565 3796 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3124 9127567 49.47 µM -0.827956260595754 0.187018470585288 no 2783 0.203847635577888 3828 17592030
SGTC_2925 9010536 32.5 µM -0.829036421844363 0.186707441644167 no 2784 0.20354189897051 3835 2994177
SGTC_467 ro 31-8220 72.8 µM -0.829446464095125 0.186589455203093 no 2785 0.203425909318041 3814 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1743 st037606 46.3785 µM -0.830547648366108 0.18627282661207 no 2786 0.203114609845198 3865 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2267 7931562 200 µM -0.830803274422804 0.186199372913012 no 2787 0.203042386288305 3778 934880
SGTC_496 calpeptin 138 µM -0.831600236185672 0.185970482592006 no 2788 0.202817314371604 3875 73364 A calpain inhibitor.
SGTC_1222 0366-0074 1.18 µM -0.832208553559224 0.185795889082173 no 2789 0.202645618324988 3933 286520
SGTC_1368 1852-0141 284 µM -0.832779374515097 0.185632149934386 no 2790 0.20248458457655 3884 2838987
SGTC_1775 st081588 35.1725 µM -0.834199507013126 0.185225175650394 no 2791 0.202084284454089 3904 1426443 YGL099W LSG1
SGTC_1417 3966-0327 90.4 µM -0.834208608706807 0.185222569122002 no 2792 0.20208172044066 3945 651118
SGTC_605 1315-0399 119 µM -0.836208783030906 0.184650315047562 no 2793 0.201518729097727 3969 24020461
SGTC_475 α-linolenic acid 10 µM -0.83754060596483 0.184269888076448 no 2794 0.201144381142196 3912 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2070 5230947 200 µM -0.838055415536359 0.184122966707675 no 2795 0.200999790617721 3943 2835538
SGTC_210 3551-0445 56.827 µM -0.838739740729205 0.183927780243184 no 2796 0.200807686127428 3910 2865180 YOR207C RET1
SGTC_1548 st061468 90.8 µM -0.841327585048866 0.183190828659519 no 2797 0.200082220563147 3880 390799
SGTC_583 1488-1091 88.9 µM -0.842139777409273 0.182959917371676 no 2798 0.199854859151569 4003 4303273
SGTC_3182 9108849 49.47 µM -0.84326800077156 0.182639458060693 no 2799 0.199539287437917 3932 17133045
SGTC_2408 sulbentine 18.36 µM -0.843280582822949 0.182635886246093 no 2800 0.199535769844714 3894 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1998 st075797 76.8 µM -0.843392118177533 0.182604225303113 no 2801 0.199504589279568 3835 24208315
SGTC_1281 0884-0031 11.8 µM -0.843399704383513 0.182602071972003 no 2802 0.199502468603939 3895 1548255
SGTC_3195 9113082 49.47 µM -0.844599217415854 0.18226179182521 no 2803 0.19916732307522 3808 17018038
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.845021576867994 0.182142070483207 no 2804 0.199049396062726 3959 688664
SGTC_797 k781-0471 270 µM -0.847141525449435 0.181541896078747 no 2805 0.19845812087996 3875 23738129
SGTC_2938 9059746 27.26 µM -0.847959554996607 0.181310636709871 no 2806 0.198230247765842 3924 6471769
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.848476587575595 0.181164565260031 no 2807 0.198086302892334 3906 689007
SGTC_1374 2889-5571 141 µM -0.849298090243767 0.180932626926983 no 2808 0.197857721628561 3931 2853281
SGTC_2095 5432005 200 µM -0.849527753620667 0.180867818390497 no 2809 0.197793846825306 3903 783734
SGTC_1888 azatryptophan 97.5 µM -0.850920768373456 0.180475036434916 no 2810 0.19740668360509 3952 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2507 purpurin 79.67 µM -0.851055369505852 0.180437111942773 no 2811 0.197369297954749 3905 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3072 9116419 49.47 µM -0.85129627361531 0.180369248577117 no 2812 0.197302397196926 3940 17170162
SGTC_111 0083-0039 52.457 µM -0.852076368496978 0.18014960356454 no 2813 0.197085853530296 3795 759313
SGTC_1235 benzylparaben 21.5 µM -0.853517271985994 0.179744341704678 no 2814 0.196686256804257 3921 7180
SGTC_2203 7227154 166.4 µM -0.854707083859829 0.17941013281127 no 2815 0.196356663946295 3893 896304
SGTC_2795 7780010 54.55 µM -0.854832088331357 0.179375042721506 no 2816 0.196322055580015 3924 953673
SGTC_3050 9093513 49.47 µM -0.856246023106112 0.17897843662359 no 2817 0.195930855311812 3900 25236664
SGTC_2756 carbadox 75.1 µM -0.856894816172529 0.178796636199256 no 2818 0.195751508964738 3915 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1986 st071812 45 µM -0.858681736062543 0.178296518806635 no 2819 0.19525806477925 3855 11838594
SGTC_1498 4478-3555 97.6 µM -0.859467621603947 0.178076847061513 no 2820 0.195041288040906 3858 3437919
SGTC_2638 epoxomicin 18 µM -0.859794687852585 0.177985475383906 no 2821 0.194951114021702 3918 9915668 A protesome inhibitor.
SGTC_2403 6032726 181.2 µM -0.860337541650439 0.177833884947075 no 2822 0.194801502117261 3983 2881040
SGTC_1016 4226-1401 38 µM -0.862306767662868 0.177284667778609 no 2823 0.194259364781976 3888 2901613
SGTC_418 lividomycin a 100 µM -0.863150326024789 0.177049727383911 no 2824 0.194027410503613 3883 72394 An antibiotic.
SGTC_343 4130-2827 29.8 µM -0.864025046676659 0.176806315787606 no 2825 0.193787065791562 3974 1118244
SGTC_2103 5378138 10 µM -0.864033466102832 0.176803973912547 no 2826 0.193784753290004 3946 244142
SGTC_2497 7-hydroxyflavone 100 µM -0.864447091858569 0.176688947479361 no 2827 0.193671166475683 3949 5281894
SGTC_261 5-fluorouridine 15.376 µM -0.86491714403429 0.176558286704845 no 2828 0.193542133553485 3915 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_936 3005-4620 401 µM -0.866613888405612 0.176087149910559 no 2829 0.193076800640901 3906 777207
SGTC_3025 9087895 49.47 µM -0.866864001776467 0.176017768035174 no 2830 0.193008264749838 3941 17173641
SGTC_3138 9097216 49.47 µM -0.86915734566542 0.175382397704772 no 2831 0.192380537100561 3906 25237486
SGTC_173 1273-0061 2.693 µM -0.869528331570151 0.175279752954798 no 2832 0.192279109317419 3932 2847414 YPL266W DIM1
SGTC_2751 anetholtrithion 17.25 µM -0.871959231369267 0.17460811207064 no 2833 0.1916153093858 3951 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2776 terbinafine 19.92 µM -0.874042046848489 0.174033946253767 no 2834 0.191047678011546 3954 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2839 9003951 25.97 µM -0.87443646945176 0.173925351842924 no 2835 0.19094030195107 3980 2990634
SGTC_487 nimodipine 119 µM -0.875756672952525 0.173562180357438 no 2836 0.190581164345933 3840 4497 L-type voltage-gated calcium channels inhibitor
SGTC_465 cgp-37157 41 µM -0.876861162085222 0.173258720217137 no 2837 0.190281026763021 3893 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3190 9110366 49.47 µM -0.87701996780836 0.173215115889879 no 2838 0.190237896251205 3936 17123768
SGTC_2104 5389443 200 µM -0.877837890683052 0.172990644151444 no 2839 0.190015849323769 4006 2244536
SGTC_2120 5538279 151.968 µM -0.879292019381985 0.172592029179084 no 2840 0.189621480952691 3934 2058197
SGTC_2040 5100729 123 µM -0.879513690929854 0.172531314655704 no 2841 0.18956140656749 3940 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.881501997785178 0.171987338295568 no 2842 0.189023086595481 3965 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_907 3448-6986 75.5 µM -0.882529800560798 0.171706573834845 no 2843 0.188745185852882 3965 590582
SGTC_910 3454-3003 490 µM -0.88454342734741 0.171157361453293 no 2844 0.188201465149445 3886 820824
SGTC_1746 st038117 42 µM -0.88474805060686 0.171101613846665 no 2845 0.188146266805365 4021 2898218
SGTC_1652 st011932 78 µM -0.885147347053499 0.170992862878457 no 2846 0.188038582982692 3863 1551076
SGTC_70 0141-0289 43.283 µM -0.886297329911912 0.170679904733308 no 2847 0.18772866374499 3962 352408
SGTC_3213 9129884 49.47 µM -0.88662888921662 0.170589741800467 no 2848 0.187639367473427 3958 17190742
SGTC_3227 9130768 49.47 µM -0.886802906538877 0.17054243241902 no 2849 0.187592511253043 3971 17720899
SGTC_3264 9137442 49.47 µM -0.889906596243636 0.169700056305485 no 2850 0.186758020877301 3923 17015726
SGTC_3355 9151058 44.0485 µM -0.890610925943702 0.169509265503489 no 2851 0.186568967819996 3938 17015728
SGTC_2759 disulfiram 3.38 µM -0.890951382725261 0.169417090980012 no 2852 0.186477626420957 3874 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_278 4092-0821 23.9 µM -0.89308357999427 0.168840556285288 no 2853 0.185906207762468 3970 877900
SGTC_1924 st058459 75.1 µM -0.893415334509366 0.168750965105684 no 2854 0.185817396856938 3920 688683
SGTC_1289 0976-0073 69.1 µM -0.893581001242515 0.168706237807574 no 2855 0.185773057614564 4015 3391136
SGTC_3070 9117005 49.47 µM -0.894092158676466 0.168568281717964 no 2856 0.18563629219648 4007 8779016
SGTC_3237 9133362 49.47 µM -0.894124885119654 0.168559451661299 no 2857 0.185627538029147 3896 43845137
SGTC_1365 1672-3266 55.4 µM -0.894467074366088 0.168467141978806 no 2858 0.185536019381376 3996 6415873
SGTC_1476 4112-3294 3.34 µM -0.895877559512983 0.168086989779337 no 2859 0.185159080252772 3998 704369
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.896397826048163 0.167946907656053 no 2860 0.185020163989337 3951 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_859 0439-0102 54.6 µM -0.898809956001306 0.167298422177023 no 2861 0.184376948061332 3940 610143
SGTC_3168 9103419 49.47 µM -0.899244413810284 0.16718179275723 no 2862 0.184261244043115 3945 16649256
SGTC_3305 9127027 53.8275 µM -0.902353076093507 0.166348807719539 no 2863 0.183434669602874 3898 41905295
SGTC_1452 4194-0072 190 µM -0.90256862169375 0.166291150485783 no 2864 0.183377443155182 4028 1343545
SGTC_1279 0874-0590 65.2 µM -0.904127326300209 0.16587458996549 no 2865 0.182963945004574 4030 3523074
SGTC_425 3825-7017 13.1 µM -0.906061057687929 0.165358742573556 no 2866 0.182451767902709 4074 3397440
SGTC_3019 9081971 49.47 µM -0.908124368486456 0.164809474123148 no 2867 0.181906258525254 4013 16451803
SGTC_1886 st057356 49.9 µM -0.908799631748339 0.16462997106308 no 2868 0.18172795050724 3940 24207747
SGTC_2359 9039622 200 µM -0.912095017245381 0.163755787759994 no 2869 0.180859350560587 3929 6463596
SGTC_2054 5233173 129 µM -0.913466396106464 0.163392884750366 no 2870 0.180498649645422 4021 6889
SGTC_2622 2-methoxyxanthone 59.94 µM -0.91434262925442 0.163161284095202 no 2871 0.180268418694736 4004 71034 A hepatoprotective.
SGTC_110 0850-0284 111.64 µM -0.914472727523271 0.163126915504429 no 2872 0.180234250991616 3787 3906265
SGTC_1264 0783-0040 158 µM -0.914908366340497 0.163011865277875 no 2873 0.180119868780873 3884 2855798
SGTC_1404 3909-7820 48.3 µM -0.915680969162924 0.162807954152897 no 2874 0.17991712471959 3939 23741373
SGTC_573 3702-0553 84.7 µM -0.915882860587515 0.162754696804229 no 2875 0.179864168620058 3935 1222756
SGTC_1387 3342-1166 1.8 µM -0.916685631542697 0.162543044338465 no 2876 0.179653698753829 3977 3418228
SGTC_1949 st076024 69.1 µM -0.917417024712552 0.162350366778703 no 2877 0.179462077447545 3918 2921930
SGTC_1993 st073995 70.8 µM -0.918171136590716 0.162151859954675 no 2878 0.179264638539063 3976 3098394
SGTC_1789 tunicamycin 25 nM -0.919858332770505 0.161708307556458 no 2879 0.178823397732955 3917 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1310 1188-0297 994 nM -0.921406839419521 0.161301912287011 no 2880 0.178419029647601 3890 1588352
SGTC_390 dec-rvkr-cmk 16.7 µM -0.921963177223344 0.161156067937425 no 2881 0.178273891575872 4026 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.922621794214716 0.160983522280168 no 2882 0.178102166995185 4052 5377381
SGTC_1946 st076057 65.1 µM -0.922641173546422 0.160978447074994 no 2883 0.178097115702633 3907 953009
SGTC_782 0083-0095 30.5 µM -0.923410577182592 0.160777034243149 no 2884 0.177896640853903 3970 3591729 An indicator and reagent.
SGTC_1713 st033146 12.748 µM -0.923518714711923 0.160748739426913 no 2885 0.177868476086123 3982 674619
SGTC_1060 3448-7350 82 µM -0.927641690827916 0.159672364192196 no 2886 0.176796732041009 3975 570178
SGTC_2798 7813637 45.45 µM -0.928010323551423 0.159576356377188 no 2887 0.176701107285506 4023 956368
SGTC_1740 st038286 13.222 µM -0.928055691013899 0.159564543350435 no 2888 0.1766893410504 4062 716786
SGTC_1852 st056254 31.4 µM -0.928623025589186 0.15941686602027 no 2889 0.176542242364759 3942 442583
SGTC_660 4031-1742 102 µM -0.928916136041145 0.159340604365714 no 2890 0.176466274949155 3929 6738706
SGTC_3344 9148862 3.898 µM -0.929606990321423 0.159160952002986 no 2891 0.176287303398766 4057 4905352
SGTC_2156 5649887 115 µM -0.930565758232964 0.158911850284816 no 2892 0.176039116976986 4039 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2688 kanamycin b 96.69 µM -0.931106357162671 0.158771507600266 no 2893 0.17589927525357 4082 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1164 k060-0068 93.7 µM -0.931410341637672 0.158692627129264 no 2894 0.17582067168967 4009 5963676
SGTC_3017 9080681 49.47 µM -0.933251057906332 0.158215531387889 no 2895 0.175345179130815 4024 16451914
SGTC_3119 9125183 49.47 µM -0.933631152057037 0.158117132056799 no 2896 0.175247095125868 3817 22695334
SGTC_2563 tomatine 8.54 µM -0.935333471560505 0.157676926003104 no 2897 0.174808235382941 3894 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_493 zm226600 134 µM -0.937302114635654 0.157168855691216 no 2898 0.174301587763067 4063 5240098 A potassium channel opener. YCR052W RSC6
SGTC_148 3253-0744 288.01 µM -0.937706516704204 0.157064620444297 no 2899 0.174197626963873 3923 6893655
SGTC_939 1165-0479 45.3 µM -0.938676779885468 0.156814719089915 no 2900 0.173948359360126 4008 1377347
SGTC_886 0866-0150 153 µM -0.940022105924867 0.156468649545227 no 2901 0.173603110862365 4082 271463
SGTC_153 4077-0274 519.67 µM -0.940424480660038 0.156365241080146 no 2902 0.173499934954297 4010 3121976
SGTC_466 geldanamycin 89.2 µM -0.940529905399932 0.156338154847849 no 2903 0.173472908663543 3932 5288382 HSP90 inhibitor.
SGTC_1152 3909-8331 15.9 µM -0.940860886267373 0.156253137730746 no 2904 0.173388077062786 3990 16001939
SGTC_221 trifluoperazine 10.304 µM -0.942081914898676 0.155939762733488 no 2905 0.173075351445631 3986 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1496 4469-0713 57.4 µM -0.942559863917272 0.155817210798614 no 2906 0.172953038705603 3990 746691
SGTC_1237 0330-0133 46.1 µM -0.942720549242549 0.155776023396226 no 2907 0.172911929826358 3955 X1237 YHR072W ERG7
SGTC_188 3229-0966 278.469 µM -0.943773117555432 0.155506403093516 no 2908 0.17264280033719 4053 5722370
SGTC_3266 9136860 49.47 µM -0.944017271227315 0.155443906002671 no 2909 0.17258041125923 3894 4871271 YPR165W RHO1
SGTC_1315 1237-0019 3.69 µM -0.948724825801408 0.154242133088161 no 2910 0.171380292084461 4063 825140
SGTC_973 1325-0077 65.9 µM -0.951762742044794 0.153469866306894 no 2911 0.170608660728217 4042 2835149
SGTC_2887 9044784 58.44 µM -0.953255374674183 0.153091364996986 no 2912 0.170230347911706 4003 6465546
SGTC_549 1661-1316 519 µM -0.955757050868661 0.15245837941086 no 2913 0.169597495870611 4064 2857282
SGTC_880 0833-0487 87.2 µM -0.957057730241034 0.152129962792188 no 2914 0.169269058583295 4027 76075
SGTC_2383 9036125 200 µM -0.958390203278123 0.151794005899548 no 2915 0.168933016707203 3960 79580
SGTC_1133 3473-0247 50 µM -0.959591992450793 0.151491421523528 no 2916 0.168630300365309 4038 711311
SGTC_1991 st073000 8.92 µM -0.961021294755231 0.151132076729805 no 2917 0.168270730412985 4120 4301969 YIL048W NEO1
SGTC_403 arphamenine a 50 µM -0.962617494757145 0.150731442574782 no 2918 0.167869757342393 4009 5487158 An arginine aminopeptidase inhibitor.
SGTC_557 1315-0110 16.2 µM -0.963519097221548 0.150505459963369 no 2919 0.16764354256531 4039 6833801
SGTC_736 0958-0254 92.6 µM -0.965645787951665 0.149973308919046 no 2920 0.167110727597207 4143 6812352
SGTC_2777 climbazole 1.536 µM -0.965830890878577 0.149927050977886 no 2921 0.167064404151085 3933 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1925 st057770 10.1 µM -0.966629671451573 0.149727541738956 no 2922 0.166864598076732 4037 5989122
SGTC_676 falcarinol 140 µM -0.966828218061121 0.149677978791255 no 2923 0.166814957780807 4029 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3200 9114385 49.47 µM -0.968753051423227 0.149198052475223 no 2924 0.166334208072127 4113 17018030 YLR208W SEC13
SGTC_91 0417-1751 58.384 µM -0.969980727460659 0.148892488474316 no 2925 0.166028049358164 4175 6795624
SGTC_735 3076-0345 636 µM -0.970588754085865 0.148741307851519 no 2926 0.165876554164528 4118 2888990
SGTC_867 0518-0118 155 µM -0.970970163866729 0.148646525954062 no 2927 0.165781568172828 4023 6848158
SGTC_2145 5634607 200 µM -0.972795784160582 0.148193411056867 no 2928 0.165327404204381 4016 308662
SGTC_3090 9117696 49.47 µM -0.974290868228119 0.147823023534574 no 2929 0.164956068738536 4025 7923821
SGTC_542 3381-0244 89.3 µM -0.974930485140543 0.147664756279665 no 2930 0.164797371551365 4085 1112843
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.979798865498841 0.146463840990648 no 2931 0.163592706123948 4146 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1400 3771-8998 51.5 µM -0.980147346738203 0.146378131003434 no 2932 0.163506695379968 3971 670767
SGTC_2754 granisetron 64.02 µM -0.980202589813109 0.146364546899425 no 2933 0.163493063202697 4084 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1076 itraconazole 331 nM -0.980896863891332 0.146193899178351 no 2934 0.163321802085916 4058 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_839 0122-0028 230 µM -0.982530107779271 0.145792986344743 no 2935 0.162919378910513 4056 759448
SGTC_2714 st079313 56.9 µM -0.983526036782979 0.145548878411223 no 2936 0.162674303651362 4038 2939799
SGTC_3105 9121040 49.47 µM -0.983814029760879 0.145478340933721 no 2937 0.162603479915482 3920 41448907
SGTC_3316 9136639 10.545 µM -0.984622455755564 0.145280457826096 no 2938 0.16240477759417 4081 4903665
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.985033515233534 0.145179909902155 no 2939 0.162303804276004 4022 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2649 anisomycin 9.56 µM -0.98572024400331 0.145012035895763 no 2940 0.162135206293517 4072 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1839 st053978 48 µM -0.985784756121673 0.144996272328496 no 2941 0.162119373860497 4073 3788398
SGTC_998 3996-0085 177 µM -0.985940683281123 0.144958176215416 no 2942 0.162081110691546 4098 715391
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.986230861245528 0.144887297894546 no 2943 0.162009919200985 4118 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1394 3474-0001 65.7 µM -0.986588005398599 0.144800094577128 no 2944 0.161922326368646 4059 5017666 YIL048W NEO1
SGTC_1794 st048918 76.9 µM -0.988696841380427 0.144285904048955 no 2945 0.16140574434074 3973 672303
SGTC_89 0302-0250 142.109 µM -0.991894943852961 0.143508472439427 no 2946 0.160624387915038 4163 4203518 YLR208W SEC13
SGTC_2052 5265182 7.135 µM -0.996672438835336 0.142352380068797 no 2947 0.15946176594506 4094 1239884
SGTC_2325 6158266 200 µM -0.998081250958096 0.14201267193565 no 2948 0.159119980446477 4117 3623240
SGTC_682 0kpi-0099 17 µM -0.998331894610171 0.141952291557946 no 2949 0.159059223251968 4127 1714895 YML126C ERG13
SGTC_1436 4092-1007 8.32 µM -0.999609965025209 0.141644673056686 no 2950 0.158749649382069 4081 2881121
SGTC_2949 9072542 2.23 µM -1.00095374816291 0.141321725528802 no 2951 0.15842458485004 4160 16457352
SGTC_2053 5265679 138 µM -1.00152372137785 0.141184896370582 no 2952 0.158286838860547 4017 764595
SGTC_1145 3546-0597 10.2 µM -1.00182791380483 0.141111907968743 no 2953 0.158213356548143 4067 875334
SGTC_2220 6782180 200 µM -1.00741657951513 0.139775507618708 no 2954 0.156867313630506 4008 833803
SGTC_1440 4100-1550 40 µM -1.00741953541912 0.139774803066704 no 2955 0.156866603693886 4092 742806
SGTC_370 0180-0345 38.7 µM -1.00894231374406 0.139412163480263 no 2956 0.156501150258704 3962 3989527
SGTC_1359 1582-0056 520 nM -1.01034968789925 0.139077576218878 no 2957 0.156163891693904 4158 3661189
SGTC_1102 cgs 12066b 26.1 µM -1.0112895674969 0.138854435137836 no 2958 0.15593892888671 4100 6438352 A 5-HT1B full agonist.
SGTC_2499 avocadenofuran 51.48 µM -1.01597839040529 0.137744883371388 no 2959 0.154819838565322 4069 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1704 st028805 70.8 µM -1.01634914382211 0.137657408011322 no 2960 0.154731577042004 4132 2876101
SGTC_1487 3970-0795 2.82 µM -1.02037400127753 0.136710225105477 no 2961 0.153775559635992 4148 3765103
SGTC_123 0083-0120 66.675 µM -1.02455265944429 0.135731572514841 no 2962 0.152787155824701 4083 16001701
SGTC_57 miconazole 162.5 nM -1.02599960602434 0.135393815076422 no 2963 0.152445884885367 4017 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_191 3914-0123 66.505 µM -1.02843745895227 0.13482605640116 no 2964 0.151872047814678 4101 3144412
SGTC_2582 agaric acid 100 µM -1.03056080467922 0.134332876954799 no 2965 0.151373412227081 3853 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1690 st023502 41.2 µM -1.03370976138759 0.133603767043121 no 2966 0.150635934161784 4129 24207482
SGTC_2419 paclitaxel 166.5 µM -1.0340802545636 0.13351816225531 no 2967 0.150549323142608 4051 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1431 4049-0260 9.09 µM -1.03414550351777 0.133503089980048 no 2968 0.150534073184417 4105 3854841
SGTC_2569 tetrandrine 100 µM -1.03506214481171 0.133291472804365 no 2969 0.150319944930034 4146 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3082 9117008 49.47 µM -1.03677275734672 0.132897175734779 no 2970 0.149920887322621 4181 41448529
SGTC_1842 st055362 61.2 µM -1.03824510183431 0.132558443269644 no 2971 0.149577979942119 4103 676032
SGTC_3222 9128301 49.47 µM -1.0384914875162 0.132501817111015 no 2972 0.149520648154362 4140 4911358
SGTC_726 3448-4391 34.2 µM -1.0391697935682 0.132346009968371 no 2973 0.149362888056896 4258 1356692
SGTC_2706 st078239 82.5 µM -1.04533860445071 0.130934827685902 no 2974 0.147933250737077 4105 15434492
SGTC_87 0100-0052 35.5 µM -1.04590237492483 0.130806379594865 no 2975 0.147803053882422 4177 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_678 1218-2179 85.9 µM -1.04594907250335 0.130795744039527 no 2976 0.14779227301025 4133 6820081 YOR116C RPO31
SGTC_2349 9023730 187.07 µM -1.04757507524623 0.130425788286721 no 2977 0.147417213002182 4163 4126287
SGTC_327 1273-0057 3.96 µM -1.04868766696466 0.130173063644912 no 2978 0.147160946163428 4008 3108138
SGTC_2653 dihydrofissinolide 100 µM -1.05445759964645 0.128867862967532 no 2979 0.145836731567996 4181 6857746
SGTC_553 k007-0256 45.7 µM -1.05478402543607 0.128794295348342 no 2980 0.145762056104537 4195 6287000
SGTC_681 1642-0006 26.6 µM -1.0553116633622 0.128675441527904 no 2981 0.145641404294583 4174 4446530
SGTC_3118 9124250 49.47 µM -1.05637974350479 0.128435082646051 no 2982 0.145397378373378 4077 1504786
SGTC_2663 amphotericin b 100 µM -1.05674770058774 0.128352350455933 no 2983 0.145313374380914 4155 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1984 st072354 53.1 µM -1.05824050130694 0.128017085808889 no 2984 0.14497290544083 4036 5762938
SGTC_3 0833-0587 95.581 µM -1.06066362918998 0.127474177309006 no 2985 0.144421397269192 4047 5382644
SGTC_2773 thioridazine 9.09 µM -1.06103564039992 0.127390969152484 no 2986 0.144336852223134 4170 5452 An antipsychotic.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.06266865570239 0.127026157722772 no 2987 0.143966120029278 4157 5024745
SGTC_1220 1838-0075 193 µM -1.06412265538134 0.126701950360891 no 2988 0.14363656947959 4059 5529645
SGTC_194 1486-1323 56.904 µM -1.06452292019279 0.126612802059381 no 2989 0.143545938478847 4227 5178754
SGTC_903 1134-0042 114 µM -1.06524793949477 0.126451434619692 no 2990 0.14338187240134 4171 701009
SGTC_2989 9073649 71.4286 µM -1.06547190145095 0.126401616419001 no 2991 0.14333121720665 4089 21367202
SGTC_1967 st070177 51.4 µM -1.06554559141911 0.126385227778923 no 2992 0.14331455282352 4201 5729214
SGTC_814 3342-0569 96 µM -1.06577078251538 0.12633515448179 no 2993 0.143263635809069 4235 4346283
SGTC_186 3455-3465 67.277 µM -1.06649788450255 0.126173571100323 no 2994 0.143099317243947 4126 755278
SGTC_843 0310-0051 143 µM -1.06659381119058 0.126152264138567 no 2995 0.14307764817873 4193 2065037
SGTC_1682 st012968 530 nM -1.06758724857895 0.125931752147005 no 2996 0.142853369044336 4179 24207270
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.06769938318999 0.125906878667502 no 2997 0.142828068387034 4262 5282309
SGTC_2502 avocadyne acetate 18.59 µM -1.06822731583889 0.125789819719851 no 2998 0.142708992936874 4094 3952079
SGTC_827 3253-0474 693 µM -1.0712468558012 0.125121753440042 no 2999 0.142029224250201 4215 5402065
SGTC_442 cape 100 µM -1.07359566366432 0.124603801351142 no 3000 0.141501970987089 4163 5281787
SGTC_59 0330-0160 1.33 µM -1.07423371686158 0.124463359008245 no 3001 0.141358972114024 4132 4293482
SGTC_3240 9133527 49.47 µM -1.07483964507453 0.124330090214783 no 3002 0.141223263716442 4110 17617455
SGTC_274 sirtinol 40.1 µM -1.07899373398983 0.123419120739417 no 3003 0.140295260487252 4229 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_329 k048-0121 21.3 µM -1.08008644034053 0.12318027477389 no 3004 0.140051844742885 4191 6832902
SGTC_3230 9131665 49.47 µM -1.08083070799987 0.123017776820715 no 3005 0.139886213012413 4143 15943720
SGTC_47 0149-0135 24.25 µM -1.08366467181766 0.122400405658409 no 3006 0.139256752485582 4198 5239155
SGTC_288 1315-0019 35.1 µM -1.08640828477231 0.121804791859976 no 3007 0.13864919890478 4239 6811474
SGTC_2680 butyl paraben 22.24 µM -1.08670625377579 0.121740228251638 no 3008 0.138583324657277 4265 7184 An antifungal and steroid mimetic.
SGTC_2013 4024628 200 µM -1.09035047732353 0.120952546782108 no 3009 0.137779393877153 4228 5230760
SGTC_187 1488-2104 32.728 µM -1.09401036031901 0.120165096760551 no 3010 0.136975217195577 4199 2852859
SGTC_916 4466-0038 42 nM -1.0944632264148 0.120067911107728 no 3011 0.136875933548447 4248 5722064 YGL116W CDC20
SGTC_2080 5212524 12.4 µM -1.09885606088667 0.119128077247092 no 3012 0.135915427378349 4098 260183
SGTC_775 4577-0580 57.3 µM -1.10778490515073 0.117233811918982 no 3013 0.133977360330377 4259 2006902
SGTC_2046 4110841 106 µM -1.10832961746837 0.117118944992416 no 3014 0.133859744478626 4191 44119630 YMR134W ERG29
SGTC_554 4483-2211 187 µM -1.1090640005131 0.116964207256838 no 3015 0.133701286741247 4260 747107
SGTC_356 1634-0012 32.5 µM -1.10945413376773 0.116882063418979 no 3016 0.13361716021011 4211 735457
SGTC_1156 4092-0367 4.88 µM -1.10992156876265 0.116783697302113 no 3017 0.133516412628563 4220 1357585
SGTC_1824 st053723 68.6 µM -1.11269240140268 0.116201813591807 no 3018 0.132920280055411 4245 675225
SGTC_271 rotenone 740 µM -1.11627026667616 0.115453498205111 no 3019 0.132153232437193 4263 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1190 1486-1332 13 µM -1.11799498015237 0.115093997851904 no 3020 0.131784568657214 4193 4150046
SGTC_1185 1319-0113 81.3 µM -1.11813837634002 0.115064144141189 no 3021 0.131753949181711 4280 4672763
SGTC_1170 0310-0127 64.8 µM -1.11842238427975 0.115005032666553 no 3022 0.1316933192825 4216 774975
SGTC_2459 5811157 9.22 µM -1.12149301845338 0.114367310510264 no 3023 0.13103903081845 4186 2870684 YBR192W RIM2
SGTC_98 0074-0023 107.663 µM -1.12210453629015 0.114240609140319 no 3024 0.130908997677812 4230 3563821
SGTC_2386 9075165 157.42 µM -1.12455403849219 0.113734095012604 no 3025 0.130389029668899 4192 16452277
SGTC_2834 9001755 58.44 µM -1.12673707191634 0.113284032728041 no 3026 0.129926831734211 4139 2989575
SGTC_2187 6125751 200 µM -1.12711783645474 0.113205663196446 no 3027 0.129846331515642 4221 874498
SGTC_1238 0333-0287 48.8 µM -1.12920427974523 0.112776914953732 no 3028 0.129405834376771 4193 7226
SGTC_1630 st005209 31.3 µM -1.12955746249116 0.112704453473817 no 3029 0.129331371812281 4198 3367314
SGTC_929 2805-0021 398 µM -1.13005465233307 0.112602502828674 no 3030 0.12922659813862 4297 3098024
SGTC_1623 st003709 20.3 µM -1.13438211824324 0.111717920507033 no 3031 0.128317148284926 4186 16192618
SGTC_2947 9072639 7.68 µM -1.14802849017391 0.108961032784433 no 3032 0.125478401354117 4229 16488146
SGTC_2439 5492030 7.2 µM -1.14918571233947 0.108729516107706 no 3033 0.125239705521273 4231 5722370
SGTC_2728 chlorpromazine 9.18 µM -1.15165950589225 0.108235789820824 no 3034 0.124730509240687 4325 2726 A thorazine and dopamine antagonist.
SGTC_2665 lovastatin 100 µM -1.15327406665021 0.107914422991201 no 3035 0.124398955510707 4258 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_665 3914-0008 307 µM -1.15519094097984 0.107533775706025 no 3036 0.124006121810989 4193 1069549
SGTC_1572 epiandrosterone 68.9 µM -1.15690511512547 0.107194200377611 no 3037 0.123655564332753 4172 441302 A steroid.
SGTC_1178 0988-0033 191 µM -1.15700304780193 0.107174823437303 no 3038 0.123635557569856 4300 5392207
SGTC_3206 9114350 49.47 µM -1.1573985426117 0.107096596607764 no 3039 0.123554784606896 4115 17087243
SGTC_2189 6047310 154.431 µM -1.15790569202696 0.106996345343502 no 3040 0.123451262216368 4226 711535
SGTC_616 4092-0450 108 µM -1.16116661338537 0.106353356137229 no 3041 0.122787074619861 4245 787165
SGTC_636 0kpi-0074 126 µM -1.16179767183123 0.106229246813958 no 3042 0.122658829995067 4254 616434
SGTC_1312 1218-2183 165 µM -1.16291841264722 0.106009090320226 no 3043 0.122431303074292 4309 6744073
SGTC_1889 st059080 5.18 µM -1.16350710706203 0.105893580310062 no 3044 0.122311908144237 4215 176925 Isolated from Daphnopsis sellowiana.
SGTC_2339 9000433 200 µM -1.16418596857048 0.105760491227929 no 3045 0.122174327639526 4266 2988954
SGTC_1712 st032288 53.4 µM -1.16495657780408 0.105609561820744 no 3046 0.122018284927485 4097 2883011
SGTC_3276 9139060 49.47 µM -1.16884427164375 0.10485050338716 no 3047 0.121233189863176 4362 4870619
SGTC_3129 9127257 49.47 µM -1.16908181048208 0.104804253154946 no 3048 0.121185335834325 4205 837894
SGTC_3303 9125618 40.5795 µM -1.16921357468022 0.104778604248635 no 3049 0.121158796651161 4258 22695467
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.17015624167802 0.104595239503632 no 3050 0.120969049352885 4250 641818 YHR062C RPP1
SGTC_629 3448-6466 76.7 µM -1.17062403877603 0.104504331367021 no 3051 0.120874965204196 4256 573744
SGTC_382 3229-0966 23.2 µM -1.17436806706693 0.103778807208646 no 3052 0.12012381504119 4291 5722370
SGTC_1497 4476-2978 41.3 µM -1.1748608089303 0.103683595606451 no 3053 0.120025203592746 4297 1528379
SGTC_2252 omeprazole 400 µM -1.17636012115766 0.103394276113377 no 3054 0.119725500202416 4247 4594 A proton pump inhibitor.
SGTC_3177 9107506 49.47 µM -1.17697331283726 0.103276118661518 no 3055 0.119603079098914 4218 8897194
SGTC_104 0074-0074 590.992 µM -1.18230363733081 0.10225313318964 no 3056 0.118542621426578 4049 3943124
SGTC_3226 9131256 49.47 µM -1.18236446695527 0.102241501576004 no 3057 0.118530557961426 4229 17178073
SGTC_337 1315-0038 354 µM -1.1827147803628 0.102174534684631 no 3058 0.118461102223039 4241 1626437
SGTC_2495 cafestol 54.53 µM -1.18293503080312 0.102132447334664 no 3059 0.118417448465892 4285 16667697 An anti-infammatory.
SGTC_197 4544-0043 41.561 µM -1.18356220019266 0.102012671503364 no 3060 0.118293205445036 4274 896523
SGTC_2761 levamisole 97.89 µM -1.18519785041244 0.101700778539881 no 3061 0.117969614830416 4285 26879 An alkaline phosphatase inhibitor.
SGTC_2944 9067346 25.62 µM -1.18757618548462 0.101248506737982 no 3062 0.117500212401919 4224 6473075
SGTC_1326 1431-2094 10.8 µM -1.18975320701222 0.100835803651333 no 3063 0.117071703026199 4257 616278
SGTC_407 eburnamonine 100 µM -1.19901366846861 0.0990939804796628 no 3064 0.115261315412674 4128 3195
SGTC_2396 5342950 42.78 µM -1.19954847500568 0.0989940637466919 no 3065 0.11515737383418 4255 1886677
SGTC_1641 st009299 47.1 µM -1.19974491782852 0.0989573812777973 no 3066 0.115119211203574 4219 4046054
SGTC_1603 st002045 67.8 µM -1.20029968061307 0.0988538421404438 no 3067 0.115011486889049 4291 5887985
SGTC_2061 5245884 80.95 µM -1.20124610484474 0.0986773875775442 no 3068 0.114827874926839 4272 573863
SGTC_1866 st057638 64 µM -1.20218405462363 0.0985027405788595 no 3069 0.114646112893287 4271 688802
SGTC_1814 st052110 31.539 µM -1.203322889537 0.0982909929460974 no 3070 0.114425697361302 4225 674163
SGTC_982 1491-0518 27.5 µM -1.20870697743255 0.0972944232419431 no 3071 0.113387720053162 4213 3091256
SGTC_600 1495-0418 41.6 µM -1.20937276623583 0.0971717057216044 no 3072 0.113259833281308 4277 5377768
SGTC_772 k072-0172 35.3 µM -1.21355750451173 0.0964029788148751 no 3073 0.112458371438843 4346 5861980
SGTC_1670 st016595 4.04 µM -1.21423596664641 0.0962787690259666 no 3074 0.112328814883854 4315 597879
SGTC_3046 9092212 49.47 µM -1.2164017317425 0.0958830576069999 no 3075 0.111915962304492 4374 25236637
SGTC_2332 7982454 138.89 µM -1.21873094298407 0.0954588190572081 no 3076 0.111473164762734 4221 2981748
SGTC_1205 4161-2785 76 µM -1.22360465231096 0.0945756029593373 no 3077 0.110550701867715 4341 3498106
SGTC_873 0591-4978 488 µM -1.22434200994991 0.0944425049853881 no 3078 0.110411617715985 4363 3305145
SGTC_2154 5570129 200 µM -1.22747156098945 0.0938791370655495 no 3079 0.109822702172284 4355 673366
SGTC_1415 3966-0071 78.1 µM -1.22911269604397 0.0935847004463231 no 3080 0.109514777822497 4232 2893185
SGTC_1361 1608-0041 5.61 µM -1.23765342890809 0.0920634071180611 no 3081 0.107922297135083 4286 X1361
SGTC_1057 3448-5381 134 µM -1.23863161762592 0.0918903455177996 no 3082 0.10774097673211 4296 5497911
SGTC_2305 7443522 69.23 µM -1.23899043281539 0.0918269242070281 no 3083 0.107674520567271 4211 5415886
SGTC_2344 7990960 76.95 µM -1.23980937178698 0.0916822965438761 no 3084 0.107522955504777 4294 140813
SGTC_155 k072-0202 43.6 µM -1.24200929395501 0.0912946178463785 no 3085 0.107116566496225 4313 5857737
SGTC_1444 4112-3581 28 µM -1.24928998806896 0.0900202535196555 no 3086 0.105779514250611 4386 2877249
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.25067635074542 0.0897790991572783 no 3087 0.105526291037055 4282 6708514
SGTC_385 1494-0393 12.4 µM -1.25163849190046 0.0896120195893922 no 3088 0.105350811013092 4303 3090647
SGTC_174 3553-0389 74.3 µM -1.25616810420472 0.0888285402516088 no 3089 0.104527514148168 4388 738071
SGTC_1249 0481-0015 10.2 µM -1.25766146559887 0.0885713572764276 no 3090 0.10425710695123 4253 4227577
SGTC_446 go6976 132 µM -1.25829817778038 0.0884618731112014 no 3091 0.104141969967789 4360 3501 A protein kinase C inhibitor.
SGTC_84 0443-0269 128.823 µM -1.25869405947219 0.0883938511738477 no 3092 0.104070428973015 4256 6150058
SGTC_3100 9120536 49.47 µM -1.25872359330853 0.0883887781175283 no 3093 0.104065093251526 4208 16421196
SGTC_3279 9140807 49.47 µM -1.26236460519925 0.0877650186736341 no 3094 0.103408809664387 4382 45595718
SGTC_1948 st076329 66.6 µM -1.26460985280235 0.0873820145972511 no 3095 0.10300560967592 4254 24208413
SGTC_506 n9-isopropylolomoucine 153 µM -1.27198040361649 0.0861334841607352 no 3096 0.101690041008394 4344 6610355
SGTC_1674 st016616 23.6 µM -1.27589557880455 0.0854757262842955 no 3097 0.100996217083872 4287 625830
SGTC_398 bronopol 33.3 µM -1.28640883125507 0.0837280982666395 no 3098 0.0991502089659086 4279 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_196 k015-0023 18.111 µM -1.2890330743908 0.0832960833577397 no 3099 0.0986932942145934 4319 5211998
SGTC_668 1682-0499 62.6 µM -1.29223085023862 0.0827719186271717 no 3100 0.0981386054793895 4348 682214
SGTC_2250 alverine citrate 130 µM -1.29346887746467 0.0825696546980297 no 3101 0.0979244707123338 4241 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_443 clozapine 122 µM -1.29560994785238 0.0822207336115896 no 3102 0.0975549500662491 4337 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1862 st057513 3.81 µM -1.29713838464098 0.0819723309687874 no 3103 0.0972917881934232 4357 5393163
SGTC_1620 st003704 16.5 µM -1.29820818583318 0.0817988028151101 no 3104 0.0971079029970159 4341 2834414
SGTC_130 0136-0219 337.655 µM -1.29902270501915 0.0816668686952515 no 3105 0.0969680686576816 4187 234244
SGTC_501 nsc-95397 161 µM -1.31123691838798 0.0797076308716569 no 3106 0.0948888665249621 4385 262093
SGTC_2664 lyso-paf C-16 73.48 µM -1.31413817196313 0.0792475202768452 no 3107 0.094399855216618 4332 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2730 imipramine 71.33 µM -1.31506022821176 0.0791017130057709 no 3108 0.0942448308679069 4352 3696 A tricyclic antidepressant.
SGTC_2977 9011197 71.43 µM -1.31529438009739 0.0790647182947489 no 3109 0.0942054930719279 4422 2704722
SGTC_1637 st007924 17.4 µM -1.31719695364093 0.0787646077640042 no 3110 0.0938863073943734 4294 683336
SGTC_1702 st027038 51 µM -1.32876300529176 0.076958732091698 no 3111 0.0919630854778712 4413 5521182
SGTC_690 glyoxal 20.3 µM -1.33095902491156 0.0766194380052869 no 3112 0.0916012468987297 4190 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_674 0498-0004 451 µM -1.33169708000654 0.0765056612531779 no 3113 0.0914798745880858 4363 4231473
SGTC_1913 st060213 96.1 µM -1.33776965137498 0.0755744026387897 no 3114 0.0904857689245199 4393 688959
SGTC_2667 digitoxin 100 µM -1.33880651294723 0.0754162617666292 no 3115 0.0903168349901754 4342 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1364 1653-0028 37.6 µM -1.33910972517156 0.0753700638985822 no 3116 0.0902674774759516 4382 5718652
SGTC_2223 6903751 107.57 µM -1.34054389455717 0.0751518439594363 no 3117 0.090034291869661 4359 5598863
SGTC_802 4112-3352 742 µM -1.34246759360149 0.0748598952132456 no 3118 0.0897222154924775 4430 704594
SGTC_1383 3049-0032 20.7 µM -1.34822283247007 0.0739916216560903 no 3119 0.0887933615186364 4453 712864
SGTC_2190 6049624 200 µM -1.35310900051709 0.0732605193193452 no 3120 0.0880104053445737 4299 2265554
SGTC_2583 asiatic acid 100 µM -1.35730861823303 0.0726365707657245 no 3121 0.0873415850519259 4417 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_799 1310-0557 151 µM -1.35814337020734 0.0725130357013272 no 3122 0.0872090978306516 4428 5354492
SGTC_1459 k035-0031 35.7 µM -1.35859471285435 0.0724463085068769 no 3123 0.0871375257510674 4143 3877128 YMR208W ERG12
SGTC_3277 9138724 49.47 µM -1.3598459521311 0.0722615693298687 no 3124 0.0869393386921893 4366 15943418
SGTC_125 0133-0007 11.75 µM -1.36324942668094 0.0717608900339965 no 3125 0.0864019573704585 4490 26541
SGTC_2291 7917025 104.35 µM -1.36329078807881 0.0717548218364839 no 3126 0.086395442047367 4301 2964612
SGTC_61 0978-8327 98.565 µM -1.36524664756694 0.0714683236569131 no 3127 0.0860877707340687 4330 6150059 YHR072W ERG7
SGTC_586 0957-0265 8.15 µM -1.37114952933993 0.0706089796614735 no 3128 0.0851641738767187 4296 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1944 st076371 56.9 µM -1.3756149421638 0.0699641960593254 no 3129 0.0844704390682565 4387 24208455
SGTC_3342 9147791 14.508 µM -1.37816417389584 0.069598136423294 no 3130 0.084076302845311 4373 1838168
SGTC_76 0433-0009 400.328 µM -1.38068838595737 0.0692371242720017 no 3131 0.0836873969057459 4479 2841569
SGTC_3343 9148379 18.9835 µM -1.38517179812727 0.0685994669915739 no 3132 0.0829999709713978 4435 1955036
SGTC_3044 9093193 49.47 µM -1.38586249968894 0.0685016352979278 no 3133 0.0828944467580273 4426 25236277
SGTC_236 1509-0011 5.31 µM -1.38817018932501 0.0681755521265236 no 3134 0.082542613752365 4462 3107280
SGTC_1443 4112-3303 14 µM -1.38944214710861 0.0679963337346019 no 3135 0.0823491707713426 4468 704433
SGTC_2662 daunorubicin 22.37 µM -1.38986094394056 0.0679374050817589 no 3136 0.0822855537109846 4321 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3326 9140064 16.379 µM -1.39222446525762 0.0676055744266676 no 3137 0.0819272182280069 4375 1868434
SGTC_3328 9140624 29.0385 µM -1.39376963009912 0.0673893162077328 no 3138 0.0816935909421332 4434 4904392
SGTC_2793 7325131 81.82 µM -1.395758241588 0.0671117814291675 no 3139 0.0813936545775497 4367 4176441
SGTC_3144 9087057 49.47 µM -1.39651168644186 0.0670068602745134 no 3140 0.0812802319511049 4350 17249618
SGTC_2871 9038510 12.99 µM -1.40001146945225 0.0665211596969595 no 3141 0.0807549419555404 4408 4945164
SGTC_1401 3807-4679 7.6 µM -1.40146823884286 0.0663197940686035 no 3142 0.0805370494169153 4361 3291456
SGTC_1539 benzyladenosine 56 µM -1.40878401218956 0.065315682592308 no 3143 0.0794495220214191 4455 92208 A nucleotide analog.
SGTC_879 0831-1030 162 µM -1.40933431736392 0.0652406311296714 no 3144 0.0793681679727348 4438 1549252
SGTC_1239 0337-0584 35.4 µM -1.41313475327192 0.0647241471299896 no 3145 0.0788080532311311 4492 914301 YML130C ERO1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.41319369127127 0.0647161624580865 no 3146 0.0787993904922515 4500 279621
SGTC_1806 st050005 60.3 µM -1.41338883982772 0.0646897300131631 no 3147 0.0787707126016328 4492 5194765
SGTC_3068 9116768 49.47 µM -1.4148471854791 0.0644924656507964 no 3148 0.07855665296859 4411 41904888
SGTC_607 4491-0986 66.8 µM -1.41524046325922 0.0644393486846052 no 3149 0.0784990022251347 4446 698981 YDR232W HEM1
SGTC_2117 5521686 200 µM -1.41672404027899 0.0642392794101281 no 3150 0.0782818127681508 4420 803312
SGTC_1617 st002906 78 µM -1.41967188909345 0.0638431773513883 no 3151 0.0778516128324689 4428 5150859
SGTC_2553 4-methylesculetin 85.09 µM -1.42028840939187 0.0637605762963635 no 3152 0.0777618670604277 4467 5319502
SGTC_715 0868-0130 184 µM -1.42278631010582 0.0634267594187515 no 3153 0.0773990555504042 4494 2876258
SGTC_314 1671-0008 2.74 µM -1.43524537580758 0.0617820168448088 no 3154 0.0756085937174826 4337 3913060
SGTC_517 1365-0151 113 µM -1.43587183539248 0.0617002043425253 no 3155 0.0755194070561298 4458 768657
SGTC_1700 st030840 7.9285 µM -1.43957091633331 0.0612188458648811 no 3156 0.0749944164489994 4503 5499307
SGTC_138 0850-0259 40.9225 µM -1.44265054457508 0.0608203390540743 no 3157 0.0745594686630607 4397 6813004
SGTC_2978 9011784 42.97 µM -1.44606110467071 0.060381379637774 no 3158 0.0740800319372814 4441 2994934
SGTC_1937 st074714 47.2 µM -1.44668006421219 0.0603019823178503 no 3159 0.0739932752537111 4399 17250970
SGTC_14 0354-0009 295 µM -1.45313933779065 0.0594782840335297 no 3160 0.0730925354284446 4561 1713507
SGTC_1243 0416-0003 5.65 µM -1.45909215320958 0.058727003792896 no 3161 0.0722698728268527 4461 2141977
SGTC_2381 9035592 200 µM -1.45942082432269 0.0586857415397058 no 3162 0.0722246589379417 4485 4749657
SGTC_260 nsc-65238 3.989 µM -1.45965451347708 0.0586564174213222 no 3163 0.0721925245028923 4455 3246252
SGTC_1822 st052468 42 µM -1.4614521278849 0.0584312309734435 no 3164 0.0719457020277829 4488 2873678
SGTC_1251 0490-5699 265 µM -1.46187477178461 0.0583783852398798 no 3165 0.0718877647252639 4476 3883818
SGTC_1038 k292-0204 154 µM -1.46286709545281 0.0582544565148711 no 3166 0.0717518746250688 4408 4454212
SGTC_254 nsc-64875 3.808 µM -1.46342049547435 0.0581854336424183 no 3167 0.0716761769305471 4472 56993
SGTC_2328 6201408 200 µM -1.46557670761884 0.0579171125830378 no 3168 0.0713818203368672 4435 2890418
SGTC_1716 st033144 30.6155 µM -1.46567421269581 0.0579050019837827 no 3169 0.0713685313329435 4456 674617
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.46626746960557 0.0578313595191336 no 3170 0.0712877170456657 4526 165521
SGTC_786 4544-0069 423 µM -1.4672674177752 0.057707400114583 no 3171 0.071151661721942 4456 748821 YLR208W SEC13
SGTC_2106 5357045 167.29 µM -1.46732702608626 0.057700017324468 no 3172 0.0711435575749108 4509 668842
SGTC_2890 9046729 58.44 µM -1.46789309256168 0.057629944146033 no 3173 0.07106663238745 4449 903329
SGTC_3291 9121177 71.43 µM -1.46862515513436 0.0575394216284991 no 3174 0.0709672440221683 4468 17015612
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.46903248814304 0.0574891016933825 no 3175 0.0709119887657203 4450 521171
SGTC_1767 st044992 70.3 µM -1.48601343696583 0.0554219935289491 no 3176 0.0686377834344075 4529 9600693
SGTC_1531 st059297 52.4 µM -1.48723498032328 0.0552755862057942 no 3177 0.0684763801413859 4528 7566702
SGTC_818 4072-2707 53.5 µM -1.49146585380047 0.0547708574753908 no 3178 0.0679196148398319 4416 882871
SGTC_2194 5927483 104.545 µM -1.49275266645462 0.054618069809467 no 3179 0.0677509708104501 4532 760979
SGTC_989 1501-0895 10.3 µM -1.4950103136621 0.0543508261607164 no 3180 0.0674558752414599 4469 2830112
SGTC_1442 4112-3290 3 µM -1.49759564828801 0.0540460650193458 no 3181 0.0671191690434667 4489 704353
SGTC_451 chloral hydrate 100 µM -1.49986925877285 0.0537791694272706 no 3182 0.066824136218723 4477 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2561 acetosyringone 100 µM -1.5002300223754 0.0537369160630982 no 3183 0.0667774144631285 4440 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1328 1441-0025 69.2 µM -1.50184634979427 0.0535479312110299 no 3184 0.0665683974576864 4486 4562601
SGTC_83 0170-0301 39.027 µM -1.50187451550129 0.0535446426833242 no 3185 0.0665647596752984 4520 3089716
SGTC_1196 1588-0294 184 µM -1.50450244118596 0.0532385187020283 no 3186 0.0662260226297817 4529 6144269
SGTC_2467 5474540 200 µM -1.50625807516889 0.0530347811451948 no 3187 0.066000468069295 4479 5413519
SGTC_565 1418-0001 44.5 µM -1.52893860009087 0.0504579707609867 no 3188 0.0631398329725711 4544 2862145
SGTC_1028 k015-0029 4.8 µM -1.5381177740731 0.0494438761420699 no 3189 0.0620099104318058 4485 4588309
SGTC_2480 5767542 37.17 µM -1.53849142179434 0.0494029435223129 no 3190 0.061964252178389 4444 2867358
SGTC_3318 9139014 38.6185 µM -1.54329424562619 0.0488792054887763 no 3191 0.0613796995905819 4503 16643984
SGTC_990 3985-0011 41.3 µM -1.54570524617154 0.0486179685742128 no 3192 0.0610878848431889 4483 5399565 YGL099W LSG1
SGTC_2177 5811945 192 µM -1.55453459546898 0.0476708059245618 no 3193 0.060028475574805 4530 5343475
SGTC_291 SEC14.278 35.5 µM -1.55524916960433 0.0475948013860538 no 3194 0.0599433690364444 4540 1068044
SGTC_626 0214-0009 33 µM -1.55571281622878 0.0475455382941831 no 3195 0.0598881988009014 4571 3437874
SGTC_1540 guanosine 70.6 µM -1.55828525500277 0.0472729546861401 no 3196 0.0595828213582908 4469 6802 Guanosine is a purine nucleoside
SGTC_2923 7992654 58.14 µM -1.5661043796281 0.0464520986109626 no 3197 0.0586620914819065 4510 2985126
SGTC_2201 6605497 169.863 µM -1.56770445589173 0.0462855401784532 no 3198 0.0584750606524462 4493 670741
SGTC_2644 guaiazulene 100 µM -1.57114619133242 0.0459289010037526 no 3199 0.0580743476856584 4564 3515 A coloring agent.
SGTC_2287 7945887 168.79 µM -1.5719879666724 0.0458420115406217 no 3200 0.0579766709774183 4544 1245853
SGTC_2656 pseudo-anisatin 100 µM -1.57683477546895 0.0453442827369599 no 3201 0.0574167738203167 4590 6708809 A neurotoxin.
SGTC_1738 st035555 74 µM -1.58825883487441 0.0441883120457906 no 3202 0.0561139109408555 4540 5331140
SGTC_318 1488-0629 67.2 µM -1.5914835544392 0.0438663459465291 no 3203 0.0557503968030702 4577 3662576
SGTC_2999 9069765 71.4286 µM -1.59177684191636 0.0438371573260369 no 3204 0.0557174276817063 4497 2097066
SGTC_1200 1643-0193 18.4 µM -1.5925902064378 0.0437562914498759 no 3205 0.055626075999584 4562 5403974
SGTC_2572 astragaloside iv 100 µM -1.59417105711179 0.0435994652791644 no 3206 0.0554488635858634 4504 45006101 An anti-inflammatory agent.
SGTC_3218 9131285 49.47 µM -1.59776122787214 0.0432449918714151 no 3207 0.0550480632532707 4522 17156417
SGTC_2601 securinine 100 µM -1.5988672023628 0.04313626424935 no 3208 0.0549250564705132 4504 442872 A GABA receptor antagonist.
SGTC_3221 9128209 49.47 µM -1.5997295812312 0.0430516376545672 no 3209 0.054829293264662 4565 16460723
SGTC_2512 diallyl trisulfide 49.23 µM -1.59977450935788 0.0430472324652936 no 3210 0.0548243078220324 4591 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2592 piperlongumine 83.33 µM -1.60388684485702 0.0426455588040223 no 3211 0.0543694985243313 4538 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_8 0354-0001 70 µM -1.60866181522322 0.0421829698702095 no 3212 0.0538451548150051 4549 4993152
SGTC_492 tmb-8 126 µM -1.60908095487429 0.0421425591203452 no 3213 0.0537993205446612 4579 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1286 0929-0070 131 µM -1.61326188088931 0.0417411737016925 no 3214 0.0533438122184053 4597 1420408
SGTC_2434 5670830 169.91 µM -1.61616494899721 0.0414642933117489 no 3215 0.0530293274166173 4558 1549830
SGTC_1066 ketoconazole 628 nM -1.62092463735072 0.0410135595157329 no 3216 0.0525169011426141 4600 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_257 daunorubicin 18.5 µM -1.62147465601438 0.0409617308637268 no 3217 0.0524579405350978 4578 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2907 7721985 69.9 µM -1.62227169988854 0.0408867191339602 no 3218 0.052372592712823 4548 3267881
SGTC_2809 7964133 12.99 µM -1.62757206936473 0.040390718732379 no 3219 0.0518078277604972 4532 1253665
SGTC_3094 9117742 49.47 µM -1.62857097800637 0.0402977918102945 no 3220 0.0517019361088628 4519 17149698
SGTC_724 3910-0327 137 µM -1.63144851655015 0.0400310690630566 no 3221 0.0513978573674323 4572 2885483
SGTC_2642 cholecalciferol 100 µM -1.6323127262008 0.0399512450545157 no 3222 0.0513068118358971 4561 9821465 A vitamin D precursor, similar to steriods.
SGTC_1114 scopoletin 1.73284 µM -1.64588731548344 0.0387142976539249 no 3223 0.0498934804717299 4600 5280460 A coumarin with genotoxic properties.
SGTC_1825 st052143 62.6 µM -1.64665382204088 0.038645392977182 no 3224 0.0498146104368864 4616 674173
SGTC_596 1155-0152 116 µM -1.65227673945548 0.0381429737456507 no 3225 0.0492390744264867 4579 280313
SGTC_1188 1403-0014 4.57 µM -1.65756227498428 0.0376755700885092 no 3226 0.0487029247194722 4602 9614867
SGTC_1520 flindersine 88 µM -1.66560585677088 0.0369732518331743 no 3227 0.0478959719273826 4580 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2835 9006588 71.43 µM -1.66741692656079 0.0368166051232909 no 3228 0.0477157652149796 4534 2345538
SGTC_5 0352-0601 109.883 µM -1.67734802308092 0.0359672450970422 no 3229 0.0467372234625719 4495 762456
SGTC_1363 1636-0063 10.4 µM -1.68517120133088 0.0353095253743246 no 3230 0.0459777727997643 4585 6072185
SGTC_838 0109-0203 71.4 µM -1.69317965700017 0.0346464799122329 no 3231 0.0452106377775397 4621 759422
SGTC_2537 larixol 68.93 µM -1.69430407788391 0.0345542095260332 no 3232 0.0451037580435875 4556 6708759
SGTC_1963 st076565 50.3 µM -1.70061656690276 0.034039944986511 no 3233 0.044507505593476 4613 4914280
SGTC_2837 9008476 45.46 µM -1.71848181643169 0.032618524980015 no 3234 0.0428543841692338 4554 2992805
SGTC_848 0368-0089 85.6 µM -1.71857452321436 0.0326112785889746 no 3235 0.042845936981528 4598 762535
SGTC_2859 9028643 45.46 µM -1.72125735950063 0.0324021501714832 no 3236 0.0426020666975179 4444 17151580
SGTC_1372 2752-0194 270 µM -1.72652336292423 0.0319948798773026 no 3237 0.0421266499671249 4533 823334
SGTC_613 3914-0030 117 µM -1.73226440772282 0.0315556960659222 no 3238 0.0416132480056933 4355 1145395
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.73398098027192 0.0314253519164237 no 3239 0.0414607289636212 4577 16623 A steroid.
SGTC_2803 7707263 71.43 µM -1.73677153057165 0.0312144078308468 no 3240 0.0412137530438829 4559 2199229
SGTC_3289 9119912 71.43 µM -1.74034025454294 0.030946347798437 no 3241 0.0408996448088132 4591 17014829
SGTC_3101 9120531 49.47 µM -1.7411645033038 0.0308847070115025 no 3242 0.0408273736976388 4575 24824904
SGTC_192 3455-0609 60.9 µM -1.75038644348591 0.0302019553672654 no 3243 0.0400258268282285 4656 3769639
SGTC_2367 9070478 135.38 µM -1.76592423758284 0.0290799245468086 no 3244 0.0387042801380739 4554 572802
SGTC_3292 9120825 59.784 µM -1.7723704893337 0.0286246964851785 no 3245 0.038166538577175 4591 24824900
SGTC_2850 9015429 58.44 µM -1.77276866359624 0.0285967732516845 no 3246 0.0381335239805958 4598 6457570
SGTC_2810 7959871 45.46 µM -1.78888710444732 0.0274852944337782 no 3247 0.0368164995058821 4561 2974535
SGTC_2342 7990637 118.86 µM -1.79259826848772 0.0272345501151043 no 3248 0.0365185917446526 4601 2033102 YER133W GLC7
SGTC_1461 k072-0203 53.8 µM -1.79328508008212 0.0271883556700237 no 3249 0.0364636759175144 4506 5418714
SGTC_922 1866-0035 480 µM -1.79780214534843 0.02688616726103 no 3250 0.0361041836350416 4574 3156169
SGTC_1123 mangostin 811.285 nM -1.80201085765525 0.0266071359219244 no 3251 0.0357718486580029 4621 5281650 An antioxidant.
SGTC_1526 st051518 75 µM -1.80971778775832 0.0261024484365954 no 3252 0.0351697813157586 4601 673993
SGTC_1002 4049-0206 172 µM -1.80990165836679 0.026090506151309 no 3253 0.0351555194656375 4613 4662749
SGTC_1473 k844-0725 134 µM -1.81095952431348 0.0260218871340894 no 3254 0.035073558671725 4663 54682906
SGTC_591 4299-0174 154 µM -1.82082862046566 0.0253889669607771 no 3255 0.0343164561298853 4667 5509088
SGTC_831 k061-1017 217 µM -1.82152257383469 0.0253449521397612 no 3256 0.0342637292172118 4656 1240153
SGTC_2468 5987765 72.9 µM -1.82300750955395 0.0252509830286041 no 3257 0.0341511267639893 4667 26772094
SGTC_1887 st057648 70.8 µM -1.82776814630362 0.0249516883441968 no 3258 0.0337921778717071 4634 688672
SGTC_2778 tioconazole 65.09 nM -1.83604658302975 0.0244383185015371 no 3259 0.033175383728941 4534 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_541 4513-1321 94 µM -1.84408212718671 0.0239485205359467 no 3260 0.0325855861040536 4618 747515
SGTC_2461 5755302 26.15 µM -1.84574661029096 0.0238481019645852 no 3261 0.0324645029980155 4629 2788904
SGTC_3286 9117135 37.221 µM -1.86287520886805 0.0228351389200852 no 3262 0.0312399127476886 4591 3438150
SGTC_77 0828-0286 12.516 µM -1.86762724646945 0.0225606198313671 no 3263 0.0309070229484262 4547 745345
SGTC_1990 st072050 59.8 µM -1.87697816799765 0.0220285490379665 no 3264 0.030260543080277 4647 17233948
SGTC_63 0099-0242 26.702 µM -1.87894783719968 0.0219178352240442 no 3265 0.0301258080318776 4650 3898502 YLR359W ADE13
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.88276441148261 0.0217046450637628 no 3266 0.029866151002773 4680 16486 A toxic proline analog.
SGTC_851 0394-0702 453 µM -1.88949832519844 0.0213327671705729 no 3267 0.0294125434894638 4666 762646
SGTC_1088 bifonazole 369 nM -1.90398888817962 0.0205507730623518 no 3268 0.0284558156841299 4662 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1483 3453-0561 55.9 µM -1.90636262492414 0.0204250162556449 no 3269 0.0283015871592263 4690 4546991
SGTC_1067 clotrimazole 1.36 µM -1.90645186721511 0.0204203010886846 no 3270 0.0282958024261729 4697 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1971 st069429 63.5 µM -1.91021370261083 0.0202223797037047 no 3271 0.0280528517922975 4659 1246522 YGL099W LSG1
SGTC_1247 0448-0043 5.84 µM -1.9312515328671 0.0191452556038782 no 3272 0.0267259769681739 4629 3089013 YGL099W LSG1
SGTC_1489 4065-0444 182 µM -1.9383572147989 0.0187926449853958 no 3273 0.0262898282547661 4672 2877968
SGTC_1135 dihydrocapsaicin 536.708 nM -1.94059328753875 0.0186828321028284 no 3274 0.0261538144641532 4596 107982 A Capsaicinoid.
SGTC_2884 9058502 51.95 µM -1.94136862859248 0.0186448830684564 no 3275 0.026106790328323 4657 6471554
SGTC_2612 dictamnine 15.46 µM -1.94579900000208 0.0184292951429849 no 3276 0.025839444404168 4585 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1921 5740136 50 µM -1.9534501357335 0.0180619790924019 no 3277 0.0253831402013448 4599 1774243
SGTC_1677 st019204 53.9 µM -1.9711366616886 0.0172367044575688 no 3278 0.0243541231442829 4675 3945625
SGTC_1909 st060837 51.5 µM -1.97120381355911 0.0172336335114949 no 3279 0.0243502839512658 4632 678937
SGTC_2033 5192550 145 µM -1.97483774026543 0.0170681447568098 no 3280 0.0241432823258858 4675 182073
SGTC_1961 st076550 68.7 µM -1.98458286782149 0.0166310428956541 no 3281 0.0235954499945573 4689 1579337
SGTC_378 3970-0959 8.33 µM -1.99206108202804 0.0163021482265984 no 3282 0.0231821781851117 4679 6615653
SGTC_3274 9138298 49.47 µM -1.99437999865095 0.016201299647226 no 3283 0.0230552713222155 4650 17015756
SGTC_1462 k081-0014 26.5 µM -1.99548715775726 0.0161533386382896 no 3284 0.022994886711795 4126 3270634
SGTC_2388 9080168 200 µM -2.00028787484797 0.0159467812862233 no 3285 0.0227345937805941 4698 15943073
SGTC_2643 anethole 100 µM -2.00266604067857 0.0158452989397247 no 3286 0.0226065730793821 4690 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_224 benfluorex 43.875 µM -2.00381563977801 0.0157964415278328 no 3287 0.0225449064302463 4694 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2726 cimetidine 79.27 µM -2.01688894756911 0.0152498602715704 no 3288 0.0218535518651095 4708 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_720 r052-1644 49.9 µM -2.01693958345346 0.0152477752269976 no 3289 0.0218509092991702 4675 1422863 YOR257W CDC31
SGTC_709 3807-1509 243 µM -2.02296425226676 0.0150014376369161 no 3290 0.0215384166213184 4732 1886677 YPL242C IQG1
SGTC_404 fumagillin 50 µM -2.02648961772268 0.0148588844680997 no 3291 0.0213573177963587 4692 12015870 A methionine aminopeptidase binder.
SGTC_1906 st060206 94.7 µM -2.03153891588961 0.0146567386774154 no 3292 0.0211001780065564 4695 5133468
SGTC_2125 5246583 200 µM -2.04973201924292 0.0139478887352609 no 3293 0.0201952943198169 4678 835267
SGTC_2213 7173844 200 µM -2.05347477691641 0.0138057848226956 no 3294 0.0200132767803911 4718 892728
SGTC_12 0849-0099 9.267 µM -2.05637011794464 0.0136967136439477 no 3295 0.0198734271688315 4685 6071388
SGTC_1297 1068-0111 14.1 µM -2.06298685713842 0.0134502400586816 no 3296 0.0195569384479151 4699 767057
SGTC_2302 7771753 200 µM -2.07394439766527 0.0130504911139827 no 3297 0.0190422375384751 4663 2203047
SGTC_2870 9038528 12.99 µM -2.08277472210415 0.0127358597088256 no 3298 0.0186358813617936 4706 6463316
SGTC_81 0411-0046 9.971 µM -2.09934667009513 0.0121630748678744 no 3299 0.0178931760810206 4721 12925265
SGTC_1828 st055811 49 µM -2.10076613724764 0.0121150677452333 no 3300 0.0178307501881434 4708 5877589
SGTC_330 1488-0319 80.1 µM -2.11077787477423 0.0117811070788832 no 3301 0.0173957043609364 4725 6846614
SGTC_177 1327-0068 8.361 µM -2.12728922198748 0.0112477812456379 no 3302 0.0166980298639467 4705 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3152 9099253 49.47 µM -2.15101805319117 0.0105181244755314 no 3303 0.0157373873851117 4576 25236131
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.15198581086446 0.010489262321187 no 3304 0.0156992359625732 4728 5393153
SGTC_589 1227-0070 34.1 µM -2.15956185061846 0.0102656917033976 no 3305 0.0154033021962007 4739 2841384
SGTC_2864 9034755 47.6 µM -2.16453045518217 0.0101213336156328 no 3306 0.0152118309263343 4688 4930451
SGTC_3026 9090633 49.47 µM -2.16959665008655 0.00997596697416453 no 3307 0.0150187076926087 4726 25236842
SGTC_2242 6630449 61.2675 µM -2.16991298374108 0.00996695102564611 no 3308 0.0150067192745157 4693 691249 YDR170C SEC7
SGTC_52 0329-0193 875 nM -2.18746752002078 0.00947764401488879 no 3309 0.0143542058979766 4714 3739292
SGTC_2173 5763948 167 µM -2.19011605603597 0.0094056737185252 no 3310 0.0142579105366814 4713 2867177
SGTC_2067 5224629 34.075 µM -2.19251290725351 0.0093409551102387 no 3311 0.0141712460697605 4699 2835000
SGTC_1356 1502-0781 85.8 µM -2.20390205919488 0.00903872632964073 no 3312 0.0137656163571284 4735 567702
SGTC_2882 9058044 58.44 µM -2.21757259700179 0.00868729457774109 no 3313 0.0132919940230324 4715 18076804
SGTC_2292 7671323 168.05 µM -2.22703842811653 0.00845102959028727 no 3314 0.0129723528140755 4732 937504
SGTC_1903 st060211 78.3 µM -2.23017320122662 0.00837403917224872 no 3315 0.0128679733210046 4724 688960
SGTC_3310 9130229 44.1445 µM -2.24337514062998 0.00805651514201471 no 3316 0.0124363167859704 4720 7761258
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -2.2549944897495 0.00778586082880878 no 3317 0.0120668373269329 4745 5106787 A p450 inhibitor.
SGTC_1304 1165-0502 251 µM -2.2858169237316 0.00710628975740584 no 3318 0.0111324855909483 4743 767425
SGTC_1376 2910-0861 41.3 µM -2.30024300278913 0.00680660801878578 no 3319 0.0107172283958361 4703 1112859
SGTC_1477 0139-0234 16 µM -2.33685412393303 0.00609561961769703 no 3320 0.00972338522119241 4745 620880
SGTC_3150 9097574 49.47 µM -2.37673193411421 0.00539679738025073 no 3321 0.00873338831025547 4758 17217476
SGTC_1189 1431-2119 7.28 µM -2.40341900802963 0.00496983308968888 no 3322 0.00812128227662702 4754 3107275
SGTC_606 k015-0008 38.6 µM -2.41967196172777 0.00472479690699209 no 3323 0.00776725690111822 4770 1970475
SGTC_2284 7945075 39.21 µM -2.43600661759117 0.00448944389866142 no 3324 0.00742520642153072 4715 1245402
SGTC_1631 benzylvanillin 81.9 µM -2.45388195337015 0.00424393955631508 no 3325 0.00706616828616755 4749 75506
SGTC_3057 9095946 49.47 µM -2.48748778496893 0.00381467205547132 no 3326 0.00643244357017772 4778 24540043
SGTC_230 MPP+ 141.667 µM -2.50059097412765 0.00365813417866514 no 3327 0.0061993142027258 4762 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2299 7976368 114.88 µM -2.53165385835323 0.00330982686781384 no 3328 0.00567629994996386 4756 2979718
SGTC_3151 9099821 49.47 µM -2.54515598009587 0.003167954075719 no 3329 0.00546144671502536 4731 17174189
SGTC_855 0428-0020 25 µM -2.56241192856928 0.00299461439056926 no 3330 0.00519739738729203 4774 6812414
SGTC_2016 5121758 140 µM -2.56519736980761 0.00296744940433388 no 3331 0.00515585651975786 4712 2795203
SGTC_1633 st005664 67.9 µM -2.5744884125916 0.00287843693435771 no 3332 0.00501942245521563 4747 2063822
SGTC_1074 carmofur 3.8 µM -2.57648252939437 0.00285964910863054 no 3333 0.00499056246482414 4792 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.65086619448623 0.00223316272611683 no 3334 0.00401428205767387 4770 75037 A free radical scavenger.
SGTC_312 4092-0653 6.84 µM -2.65829549792661 0.00217798127893135 no 3335 0.00392684991133117 4702 1148278
SGTC_2852 9023854 51.95 µM -2.69287679821743 0.00193704452853276 no 3336 0.003541922009617 4755 19798528
SGTC_2249 haloperidol 116.36 µM -2.70610253926922 0.00185148888743501 no 3337 0.00340390107924373 4731 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_126 0417-1624 672.48 µM -2.78505320865907 0.00140839791259774 no 3338 0.00267594699876055 4790 41912 YDL195W SEC31
SGTC_2618 avocadyne 43.43 µM -2.89877628474308 0.000938697823003568 yes 3339 0.00187311044360255 4770 3015189
SGTC_2303 7774051 200 µM -3.08242418028443 0.000473439202161306 yes 3340 0.00102661014040791 4783 2953184
SGTC_2614 arthonioic acid 13.39 µM -3.16102294303066 0.000349316545965024 yes 3341 0.000786080572937289 4738 6710684
SGTC_2868 9035608 32.47 µM -3.25741545367262 0.000238408306411803 yes 3342 0.000562158727894272 4796 6462614
SGTC_43 0570-0105 72.5 µM -3.30984498242132 0.000192864086078282 yes 3343 0.000466738269817649 4786 1114046 YDL195W SEC31
SGTC_421 streptovitacin 30 mM -3.32885942478377 0.000178459886265149 yes 3344 0.00043601203188364 4787 91467 include heat shock
SGTC_1104 tacrolimus 29.8 µM -3.34197508841088 0.000169117469814027 yes 3345 0.00041592263032852 4809 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -3.41785594324191 0.000123449927676802 yes 3346 0.000315582520357829 4803 2333 A French combination drug.
SGTC_3208 9114115 49.47 µM -3.47066220723101 9.87998275943881e-05 yes 3347 0.000259588331730385 4776 650895
SGTC_700 3453-2283 142 µM -3.5329220597483 7.56848061128049e-05 yes 3348 0.000205496809012624 4805 565664
SGTC_121 0557-0495 61.343 µM -3.75405068045043 2.83820505337556e-05 yes 3349 8.69998295217421e-05 4799 3104427
SGTC_2239 6685329 187.64 µM -3.90420229111876 1.41429524640004e-05 yes 3350 4.72683419110952e-05 4784 805680
SGTC_2851 9015922 71.43 µM -3.94363099127405 1.17306403715173e-05 yes 3351 4.01285604951719e-05 4802 2996893
SGTC_704 1310-0270 142 µM -4.04194644513217 7.30411534126691e-06 yes 3352 2.65046705112893e-05 4800 5718033
SGTC_3212 9128307 49.47 µM -4.36488483035576 1.42932977538471e-06 yes 3353 6.35948759792661e-06 4788 27243542