SGTCid condition conc unit DEF1|YKL054C.score DEF1|YKL054C.strain.pval DEF1|YKL054C.strain.significant DEF1|YKL054C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_160 3453-0671 289.699 µM 5.50456670997986 5.73020136445183e-09 yes 1 1.85038655926386e-08 14 5322268
SGTC_3044 9093193 49.47 µM 5.19816184473577 3.5465248643334e-08 yes 2 1.00634428811709e-07 6 25236277
SGTC_2496 diffractaic acid 79.83 µM 4.81264943223988 3.05461209658263e-07 yes 3 7.44712134288905e-07 12 94870 An apoptosis inducer which activates caspases.
SGTC_2188 6126565 140.678 µM 4.59043589496182 9.84631770370659e-07 yes 4 2.21160647502398e-06 7 874518
SGTC_2636 apigenin dimethyl ether 100 µM 4.43545530321864 2.1604292741678e-06 yes 5 4.59389470850261e-06 30 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2459 5811157 9.22 µM 4.31611055060767 3.88982023056542e-06 yes 6 7.94012352913582e-06 7 2870684 YBR192W RIM2
SGTC_1749 st037932 54.2 µM 4.21563929259469 6.30875464230663e-06 yes 7 1.24535799207382e-05 24 594497
SGTC_1678 st019265 80.2 µM 4.16035202812146 8.1953619382665e-06 yes 8 1.58878718155441e-05 15 5367020
SGTC_3212 9128307 49.47 µM 4.11954296223031 9.92096980377346e-06 yes 9 1.89812319972894e-05 40 27243542
SGTC_2469 5655019 90.81 µM 4.10641806917628 1.05459200444608e-05 yes 10 2.0092095101333e-05 20 2788239
SGTC_771 0250-0039 27.3 µM 3.99337789245894 1.77163185815462e-05 yes 11 3.25693152279197e-05 13 3005115
SGTC_2167 5876490 200 µM 3.97779035836571 1.90102944418938e-05 yes 12 3.47793284951054e-05 31 686534
SGTC_3017 9080681 49.47 µM 3.97744385722699 1.90400534863048e-05 yes 13 3.48300314401604e-05 14 16451914
SGTC_132 0417-1715 25.805 µM 3.96778600289752 1.9887529402907e-05 yes 14 3.62717141874348e-05 23 6769098
SGTC_2390 9097792 176.6 µM 3.95278245993782 2.12754490583883e-05 yes 15 3.86238299326844e-05 14 4497149
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 3.93555093141948 2.29827838466929e-05 yes 16 4.1503028917054e-05 20 165521
SGTC_2474 5321570 43.32 µM 3.85007214587283 3.35530842045937e-05 yes 17 5.90415185471312e-05 15 2841384
SGTC_1583 clindamycin 39.6 µM 3.824881786882 3.74571979667842e-05 yes 18 6.54174247699281e-05 17 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2159 5658611 73.75 µM 3.79214734524606 4.31747436480727e-05 yes 19 7.4675126098227e-05 14 793844
SGTC_2301 7769476 200 µM 3.79052845444567 4.34778880096634e-05 yes 20 7.51635546368639e-05 26 977820
SGTC_1203 3992-3522 103 µM 3.73947992197363 5.41359371384315e-05 yes 21 9.2200687693184e-05 44 5322312
SGTC_164 4100-3994 89.624 µM 3.71782310952229 5.93647445562454e-05 yes 22 0.000100473445165987 41 4615967
SGTC_1564 D-Arginine 115 µM 3.70784221534034 6.19316282904419e-05 yes 23 0.000104516414101179 34 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2766 oltipraz 83.91 µM 3.5870710697381 0.000102526914858579 yes 24 0.000167206600185733 42 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2405 ticlatone 3.52 µM 3.58517081543493 0.000103330984000905 yes 25 0.00016842882711148 82 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2851 9015922 71.43 µM 3.57278307832703 0.00010871962897759 yes 26 0.000176603668368562 57 2996893
SGTC_65 0798-0905 34.986 µM 3.55774078054144 0.000115617728701821 yes 27 0.000187029087027488 108 3602145
SGTC_2077 5212015 200 µM 3.51580341057175 0.000137080968783987 yes 28 0.000219212744286044 87 780900
SGTC_1934 st074720 32.6 µM 3.51124118957599 0.000139628809960715 yes 29 0.000223009764759943 75 17250992
SGTC_1010 4112-3296 15.2 µM 3.48548162070274 0.000154867254286527 yes 30 0.00024562598468288 35 704384
SGTC_2944 9067346 25.62 µM 3.47848225409359 0.000159269201585953 yes 31 0.000252130912450569 44 6473075
SGTC_2453 5731132 22.18 µM 3.42512325560084 0.000196883874163446 yes 32 0.000307260281594991 37 1362040
SGTC_2881 9058953 51.95 µM 3.38348803037448 0.000231835447565983 yes 33 0.000357856635969019 47 17122249
SGTC_963 1269-2853 151 µM 3.3321438331897 0.000282905250826394 yes 34 0.000430898515640332 47 3668223
SGTC_2273 7815444 169.05 µM 3.31428567502911 0.000302997930935459 yes 35 0.000459387927223125 48 2824616
SGTC_3058 9093861 49.47 µM 3.30323458673707 0.00031608883211136 yes 36 0.000477881984923034 42 17217477
SGTC_18 0111-0177 500 nM 3.29906220633609 0.000321166746894966 yes 37 0.000485042058590313 105 721752
SGTC_883 0850-0245 24.6 µM 3.29207062551919 0.000329846142098502 yes 38 0.000497263165280313 55 6823229 YPR165W RHO1
SGTC_2450 5739737 12.93 µM 3.26710897473977 0.000362644833449842 yes 39 0.000543259239532831 51 2262825
SGTC_126 0417-1624 672.48 µM 3.25093558884898 0.000385487046663596 yes 40 0.000575129571136836 62 41912 YDL195W SEC31
SGTC_2621 lithochol-11-enic acid 100 µM 3.20927918695681 0.000450613847916096 yes 41 0.000665341065980643 63 6708711
SGTC_2808 7946468 45.46 µM 3.19014975689938 0.000483816459979577 yes 42 0.00071099543161432 65 2970879
SGTC_25 0118-0223 35.662 µM 3.09740946473986 0.000679334450024637 yes 43 0.000976100085767155 53 5333628
SGTC_2282 7944268 200 µM 3.09431969711922 0.000686956775041525 yes 44 0.000986323977347222 82 2970414
SGTC_2204 7233102 200 µM 3.08118402573297 0.000720250580353231 yes 45 0.00103089588813594 25 2172480
SGTC_1673 st016611 27.3 µM 3.07649531749809 0.000732490447346721 yes 46 0.00104724796256758 91 5226799
SGTC_2801 7907800 81.82 µM 3.07611054437482 0.000733503360186922 yes 47 0.00104860038249681 72 6620925
SGTC_870 0573-2213 57.6 µM 3.06621574013983 0.00075999894800256 yes 48 0.00108393416137156 51 3916321
SGTC_724 3910-0327 137 µM 3.00450824532159 0.000946129928349513 yes 49 0.00133005274286169 58 2885483
SGTC_3082 9117008 49.47 µM 2.98616170662923 0.00100905429349246 no 50 0.00141251606942125 56 41448529
SGTC_1567 st069303 68.4 µM 2.98233293717741 0.00102266109330354 no 51 0.00143030362334836 71 5581319
SGTC_733 4069-0007 56.1 µM 2.97949536564867 0.00103285373309363 no 52 0.00144361798655985 149 5717425 YNL287W SEC21
SGTC_1490 4089-0339 670 nM 2.97671290285217 0.0010429388369962 no 53 0.00145678353696878 29 742542
SGTC_2715 st079500 56.4 µM 2.95601356486086 0.00112084619734503 no 54 0.00155821692199324 44 28246688
SGTC_1552 6-methylflavone 10.6 µM 2.9552779461881 0.00112371056362257 no 55 0.00156193740165737 45 689013
SGTC_1597 7-benzyloxygramine 47.5 µM 2.93068937606742 0.00122340046598595 no 56 0.00169105389157583 229 260807
SGTC_1574 spiramycin 23.7 µM 2.92878614009698 0.00123144463891874 no 57 0.00170144231241028 75 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2894 9048625 32.47 µM 2.86490030555264 0.00153121638856841 no 58 0.00208570273359537 57 4092861
SGTC_2397 5161689 200 µM 2.85313697473823 0.00159318077035668 no 59 0.0021644978838889 98 2259942
SGTC_2150 5556613 200 µM 2.845213672477 0.00163619646769961 no 60 0.0022190820270905 70 743190
SGTC_2828 7998861 71.43 µM 2.77440965306898 0.00207021916556186 no 61 0.00276509961444012 55 2988188
SGTC_2560 caryophyllene 100 µM 2.73562452087373 0.00234998251123703 no 62 0.00311310123804834 83 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2213 7173844 200 µM 2.73058392798388 0.00238875076733252 no 63 0.0031611116525574 68 892728
SGTC_1293 1000-1278 195 µM 2.7104248774494 0.00254965111483762 no 64 0.00335985342841984 80 678847
SGTC_1719 st032227 49.2 µM 2.69745972292714 0.00265824459015298 no 65 0.00349353682671965 98 3125804
SGTC_1762 st045503 25.4615 µM 2.6832978792196 0.0027816199727854 no 66 0.00364500130226956 103 4645554
SGTC_2887 9044784 58.44 µM 2.66500563680482 0.00294861809904653 no 67 0.00384935161625385 136 6465546
SGTC_3027 9089541 49.47 µM 2.66446267162301 0.00295371033831613 no 68 0.00385557119812618 104 9943819
SGTC_768 0384-0033 77.3 µM 2.66237826500793 0.00297333280053248 no 69 0.00387953148559613 181 3965305 YMR134W ERG29
SGTC_3253 9135987 49.47 µM 2.66172443581549 0.00297951206312156 no 70 0.0038870747046626 63 4182430
SGTC_3077 9117319 49.47 µM 2.65770002404906 0.00301780178605758 no 71 0.00393379436306519 69 17154678
SGTC_2156 5649887 115 µM 2.6570515777556 0.00302401264031139 no 72 0.00394136909288313 96 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1469 k284-2957 126 µM 2.64654152620885 0.00312629711713153 no 73 0.00406597601020218 69 23884841
SGTC_2678 equilin 100 µM 2.6410072703002 0.00318139931736452 no 74 0.00413299727662005 91 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_981 1488-1094 54.9 µM 2.63715921247902 0.00322022627168312 no 75 0.00418017910409859 71 3449522
SGTC_855 0428-0020 25 µM 2.62087376538632 0.00338930919007427 no 76 0.00438523654010553 77 6812414
SGTC_1394 3474-0001 65.7 µM 2.61906857616958 0.0034085343800024 no 77 0.00440851104357406 108 5017666 YIL048W NEO1
SGTC_2842 9000675 19.48 µM 2.61699246272295 0.00343076601581824 no 78 0.00443541500410233 107 2989072
SGTC_1191 1487-1166 10.6 µM 2.56951698013135 0.00397601232803108 no 79 0.00509202003704881 121 3955771
SGTC_3020 9089140 49.47 µM 2.56724109608599 0.00400399980289783 no 80 0.0051255654818315 106 17217859
SGTC_75 0159-0059 199.013 µM 2.56689042663088 0.0040083277770052 no 81 0.00513075163509656 107 5377270
SGTC_271 rotenone 740 µM 2.56216028688196 0.00406711801664487 no 82 0.00520116489098792 121 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_181 1447-1644 8.07 µM 2.54881835681831 0.00423712368139883 no 83 0.00540442909697762 115 534600
SGTC_2074 5212007 75.395 µM 2.54738259072579 0.00425579206697252 no 84 0.0054267184199759 80 758611
SGTC_1384 3089-0840 101 µM 2.54278221278155 0.00431610430395121 no 85 0.00549868758918586 92 1069836
SGTC_1341 1486-1360 280 µM 2.53552282389992 0.00441283184376522 no 86 0.00561398057604788 112 3976547
SGTC_2091 4-phenylthiadiazole 200 µM 2.52748899299421 0.00452213199099218 no 87 0.00574407124967734 105 270010
SGTC_2784 7567673 72.73 µM 2.50944534732714 0.00477647184488808 no 88 0.00604604628769246 144 3471247
SGTC_2196 6573537 42.6665 µM 2.50378241451359 0.00485888470030087 no 89 0.00614367866313312 62 2903087
SGTC_210 3551-0445 56.827 µM 2.50340259198248 0.00486445735794869 no 90 0.00615027673792002 150 2865180 YOR207C RET1
SGTC_1482 3346-2049 8.48 µM 2.49876223805854 0.00493300079373114 no 91 0.00623139478601607 123 3826804
SGTC_91 0417-1751 58.384 µM 2.48712800662986 0.00510864977340881 no 92 0.00643895265800378 171 6795624
SGTC_2319 6033012 152.6 µM 2.48014675582905 0.00521670299793676 no 93 0.00656641589928587 101 847246
SGTC_1500 4488-1866 171 µM 2.47729279916069 0.00526145786314796 no 94 0.00661916248054736 114 2900003
SGTC_1865 st057639 52.2 µM 2.46490764287416 0.00545965998995375 no 95 0.00685242859228835 101 688818
SGTC_2257 7960413 200 µM 2.4542880190997 0.00563486297448594 no 96 0.00705819329944809 178 2974689 YIL048W NEO1
SGTC_1032 k061-1018 98.7 µM 2.44447298546569 0.00580121271866674 no 97 0.00725319721639088 146 4005393
SGTC_688 0527-0193 473 µM 2.43061712050432 0.00604346354032953 no 98 0.00753656678396953 84 4007154
SGTC_415 dibenzyl ketone 100 µM 2.42536768958042 0.00613755881569445 no 99 0.00764644454473646 107 7593
SGTC_1166 k206-0078 225 µM 2.42506112062583 0.00614309391720018 no 100 0.00765290481875624 130 5404595
SGTC_2707 st078556 66.6 µM 2.41957636735516 0.00624287118225925 no 101 0.00776929880954579 81 17250899
SGTC_2523 spermine 47.74 µM 2.40591352005042 0.00649768810482056 no 102 0.00806604151079 122 1103 A DNA binding polyamine.
SGTC_939 1165-0479 45.3 µM 2.40276761487056 0.00655764746215153 no 103 0.00813576195551323 173 1377347
SGTC_1925 st057770 10.1 µM 2.39835387651825 0.0066425957624004 no 104 0.00823447298562569 123 5989122
SGTC_2376 9072922 81.32 µM 2.39577644006115 0.00669265060350491 no 105 0.00829260128679382 165 17087968
SGTC_1468 k284-1086 134 µM 2.38849920881576 0.00683578120245664 no 106 0.00845867237631663 191 15996457
SGTC_622 1348-1566 26.3 µM 2.38030340693651 0.00700020981257401 no 107 0.00864919427045538 140 7340407
SGTC_2294 7971431 200 µM 2.37949791602891 0.00701655690922814 no 108 0.00866812052198729 112 5741572
SGTC_2852 9023854 51.95 µM 2.37676983045647 0.0070721728275259 no 109 0.00873249118188305 132 19798528
SGTC_292 k038-0015 474 µM 2.36867084978786 0.00723958036766004 no 110 0.0089260665049842 107 46368540
SGTC_31 0508-1974 57.237 µM 2.36383019811375 0.0073412975694229 no 111 0.00904355023077375 131 6810525
SGTC_1402 3909-7673 35.9 µM 2.36240862827402 0.0073714075131939 no 112 0.00907830831669056 124 5328014
SGTC_1015 4130-4525 82 µM 2.36039795539688 0.00741418094422363 no 113 0.00912766998580217 136 1363237
SGTC_772 k072-0172 35.3 µM 2.35256052525264 0.00758300302325767 no 114 0.00932232759917919 137 5861980
SGTC_2157 5649910 96.377 µM 2.34435923233298 0.00776327855366876 no 115 0.00952990189210184 141 2858091
SGTC_610 4215-0184 155 µM 2.33874646773725 0.00788881840785959 no 116 0.00967427935661042 138 5605015
SGTC_1121 fusaric acid 630.51 nM 2.33824600930961 0.00790009831426132 no 117 0.00968724500875708 158 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1173 0443-0020 122 µM 2.33618254856725 0.00794675692085975 no 118 0.00974086472227094 184 5331295
SGTC_1594 piperine 70.1 µM 2.32464023522954 0.00821224472952475 no 119 0.0100456027301521 150 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_589 1227-0070 34.1 µM 2.31925401398756 0.00833877896206776 no 120 0.0101906336413255 129 2841384
SGTC_3159 9100096 49.47 µM 2.30804430467858 0.00860762020719782 no 121 0.0104983362085664 148 25236875
SGTC_1590 st077108 57.8 µM 2.3047395737368 0.00868831480992803 no 122 0.0105905815593159 90 5489485
SGTC_3114 9122766 49.47 µM 2.29946551062879 0.0088184707797266 no 123 0.0107392598316618 155 17176985
SGTC_1664 st014217 9.02 µM 2.29433812330698 0.00894664220140315 no 124 0.0108855421858086 137 3982782
SGTC_2868 9035608 32.47 µM 2.29212799855038 0.00900239107406834 no 125 0.0109491290964475 149 6462614
SGTC_1127 asiatic acid 681.4 nM 2.26949142153319 0.00959113058965676 no 126 0.0116192291549029 169 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3217 9129673 49.47 µM 2.26934868299905 0.00959494730754329 no 127 0.0116235651117313 187 17248312
SGTC_801 0866-0028 10.1 µM 2.26677415193743 0.00966401654946643 no 128 0.0117020129559495 193 6849771
SGTC_757 1066-0008 322 µM 2.26440119909825 0.00972806225814745 no 129 0.0117747251470535 160 6842497
SGTC_1311 1190-0148 100 µM 2.2631013701481 0.00976330143742848 no 130 0.011814720560185 192 1961333
SGTC_1328 1441-0025 69.2 µM 2.25626025092757 0.00995061227780914 no 131 0.0120271685951529 118 4562601
SGTC_3052 9092717 49.47 µM 2.2412599388961 0.0103723365086311 no 132 0.0125046211536169 177 25237534
SGTC_3259 9138485 49.47 µM 2.22661959996511 0.0107988807804805 no 133 0.0129863539499865 163 17646153
SGTC_2434 5670830 169.91 µM 2.22272198560457 0.0109149796000545 no 134 0.0131172762268712 174 1549830
SGTC_2315 7733312 200 µM 2.22197174357401 0.0109374514029535 no 135 0.0131426076242081 159 726316
SGTC_926 2268-1401 59.4 µM 2.21652365988847 0.0111018473582793 no 136 0.0133278296692278 163 2931578
SGTC_89 0302-0250 142.109 µM 2.20967128569617 0.011311665724599 no 137 0.0135639919854542 183 4203518 YLR208W SEC13
SGTC_1905 st060207 84.5 µM 2.20634331172967 0.0114148050965599 no 138 0.0136799854812617 129 1948547
SGTC_798 1287-0182 476 µM 2.20613290313231 0.0114213533778132 no 139 0.0136873477601955 197 1649755
SGTC_2911 7942208 15.64 µM 2.19784155864622 0.0116820058146403 no 140 0.0139801993687746 145 1243384
SGTC_2720 fluspirilene 36.88 µM 2.1941622615691 0.0117993150358794 no 141 0.0141118732711539 119 3396 An atypical antipsychotic.
SGTC_851 0394-0702 453 µM 2.19098811214893 0.0119013382971164 no 142 0.0142263263636348 150 762646
SGTC_3229 9132204 49.47 µM 2.19004188690534 0.0119318994764547 no 143 0.0142605995828628 91 17682924
SGTC_2185 6113692 200 µM 2.18469660173876 0.0121058229584651 no 144 0.0144555497632842 147 874150
SGTC_2421 5690543 90.72 µM 2.18290634403022 0.0121645631488947 no 145 0.0145213538795333 175 3397993
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.18156139739077 0.0122088545852843 no 146 0.014570959246611 246 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2158 5657123 3.6195 µM 2.18100483327874 0.0122272240548061 no 147 0.0145915294968855 125 2858827
SGTC_2246 7293507 91.5585 µM 2.18082007836249 0.0122333272070909 no 148 0.0145983634416547 185 887656
SGTC_590 k048-0076 22.4 µM 2.17101924599518 0.0125608926609507 no 149 0.0149648587874915 153 6832814
SGTC_2491 paeonol 100 µM 2.15702851663861 0.0130416369013522 no 150 0.0155017212959146 120 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3015 9080845 49.47 µM 2.15189130497651 0.0132221099493874 no 151 0.0157029581213954 134 5296973
SGTC_2855 9016525 58.44 µM 2.14962549156367 0.0133023924243478 no 152 0.0157924251797667 189 43811474
SGTC_2959 9079155 11 µM 2.14269854214924 0.0135504451605745 no 153 0.01606865626209 172 16189457
SGTC_2195 6536160 144.242 µM 2.14136005007666 0.0135988338307958 no 154 0.0161225069900756 145 3834386
SGTC_2189 6047310 154.431 µM 2.13748208304647 0.0137398714622914 no 155 0.0162794007349896 158 711535
SGTC_1075 aripiprazole 15.2 µM 2.13247562410565 0.0139238158556105 no 156 0.0164838831488702 226 60795 An atypical antipschotic. YIL048W NEO1
SGTC_268 camptothecin 39.6153 µM 2.12485840859585 0.0142077547951449 no 157 0.0167992146701076 305 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_24 0417-1663 219 µM 2.1213581320006 0.0143398948128793 no 158 0.0169458378898413 164 4329390
SGTC_2581 avocatin a 64 µM 2.10482124654256 0.014978589067372 no 159 0.0176534354960783 236 6710728 A skin care supplement.
SGTC_2611 pyromycin 23.93 µM 2.10390684870117 0.0150146077684253 no 160 0.0176932867278738 211 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1062 mesoridazine 14.2 µM 2.09518742411537 0.0153618269812691 no 161 0.0180771673793851 201 4078 A neuroleptic.
SGTC_2470 5664817 21.68 µM 2.09166467319692 0.0155040508399261 no 162 0.0182342613836521 149 2859561
SGTC_2283 7944793 200 µM 2.09065073105455 0.0155451955656498 no 163 0.0182796922826139 236 2970533
SGTC_1425 4048-4433 7.33 µM 2.07257758530428 0.0162944593907771 no 164 0.0191058044272534 221 23734946
SGTC_191 3914-0123 66.505 µM 2.06715804371553 0.016525082091427 no 165 0.0193596321080108 86 3144412
SGTC_2680 butyl paraben 22.24 µM 2.06338257031584 0.0166873894841387 no 166 0.0195381473065284 140 7184 An antifungal and steroid mimetic.
SGTC_683 panaxydol 45 µM 2.06329729247063 0.0166910712701836 no 167 0.019542195579342 202 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1081 sertraline 6 µM 2.04582589545207 0.0174601853883892 no 168 0.0203867516512265 242 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2752 diclazuril 33.15 µM 2.04126834315238 0.0176657218844537 no 169 0.020612080927656 373 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1421 4029-0249 71.4 µM 2.03823077292692 0.0178038539415821 no 170 0.0207634296750174 233 2894095
SGTC_876 0720-0963 56.8 µM 2.0338883296799 0.018002923936884 no 171 0.0209814279432456 197 765861
SGTC_3166 9102297 49.47 µM 2.02876904918858 0.0182400409018334 no 172 0.0212409095803339 240 25237072
SGTC_3251 9135047 49.47 µM 2.02502138761322 0.0184153092744918 no 173 0.0214325840604575 141 17682963
SGTC_710 3448-4187 58 µM 2.02484870216276 0.0184234197763123 no 174 0.0214414511998155 303 3946412
SGTC_1843 st055809 45.5 µM 2.02376254563817 0.0184745029696275 no 175 0.0214972948379498 201 16413835
SGTC_2152 5568786 200 µM 2.0234429418867 0.0184895572515167 no 176 0.0215137503318887 183 5399883
SGTC_960 1222-0186 7.7 µM 2.00684351199832 0.0192859293309937 no 177 0.0223831640730927 224 3126296
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 2.00337231556168 0.0194560982535739 no 178 0.0225686703498048 307 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1681 tripelennamine 100 µM 2.00288919671622 0.0194798830678381 no 179 0.022594591461583 180 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2350 9023895 38.85 µM 1.99765152507654 0.0197393323272764 no 180 0.0228772265071664 225 2997209
SGTC_1085 doxorubicin 7.67 µM 1.99196177477821 0.0200244936484129 no 181 0.0231876260582376 265 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1987 st072290 61.9 µM 1.99081994970766 0.0200821391779542 no 182 0.0232503426506945 208 54697379
SGTC_1596 piperlongumine 63 µM 1.98794854308731 0.0202277257167264 no 183 0.0234086906191223 213 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2435 5706476 10.6 µM 1.98401866144883 0.0204284289375548 no 184 0.0236268798055454 253 5725375
SGTC_2781 5567276 71.43 µM 1.97390350105526 0.0209527972044151 no 185 0.0241963583029976 267 2853274
SGTC_2228 7354201 200 µM 1.97265322016506 0.0210183957880502 no 186 0.0242675425417636 151 753451
SGTC_1440 4100-1550 40 µM 1.96601701315437 0.0213694944762211 no 187 0.0246483226989767 148 742806
SGTC_503 tyrphostin 8 294 µM 1.96488901107462 0.0214296635217351 no 188 0.0247135424350067 249 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1163 k060-0048 49.9 µM 1.96374840429619 0.0214906504860652 no 189 0.0247796381084922 260 6809982
SGTC_829 1635-0120 117 µM 1.96121717466989 0.0216265166880569 no 190 0.0249268471106579 260 285054
SGTC_306 1672-3436 11.6 µM 1.96066448504635 0.0216562791850991 no 191 0.0249590872944526 223 6797378
SGTC_2738 aclarubicin 5.55 µM 1.95638458276723 0.0218879268661253 no 192 0.0252099334719353 147 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_834 0312-0008 75.7 µM 1.95227295018728 0.0221124342320641 no 193 0.0254529035837303 289 6385573 YIL048W NEO1
SGTC_969 1313-0238 134 µM 1.94815378331284 0.0223392988198918 no 194 0.0256982824889354 287 5212874
SGTC_679 0422-0091 41.4 µM 1.94737557491617 0.0223823786935024 no 195 0.0257448620697442 285 627384 YHR062C RPP1
SGTC_1683 st010134 710 nM 1.94240260138085 0.0226593291283964 no 196 0.026044190317109 259 3818134
SGTC_1896 st058441 89 µM 1.94071365689787 0.0227540430386995 no 197 0.0261465094679393 208 688759
SGTC_1404 3909-7820 48.3 µM 1.93210598797671 0.0232419487796363 no 198 0.0266732127064507 206 23741373
SGTC_1423 4048-0112 5.59 µM 1.93081585946482 0.0233158301890911 no 199 0.0267529141836603 247 X1423
SGTC_1413 3910-0535 34.4 µM 1.92948737000526 0.0233921148659791 no 200 0.0268351932625883 228 2876951
SGTC_878 0828-0289 13.7 µM 1.92854513437817 0.0234463472432537 no 201 0.0268936779575288 316 745350 YLR208W SEC13
SGTC_2697 mebhydrolin 72.4 µM 1.91482823454783 0.0242479069323346 no 202 0.0277572062285946 311 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1148 3909-7663 27.7 µM 1.91141314833606 0.0244510106349361 no 203 0.027975754166548 235 4084526
SGTC_3330 9141424 71.43 µM 1.90817971362985 0.0246446253142941 no 204 0.0281839963287631 260 27261020
SGTC_2136 5328288 199.296 µM 1.90256800658521 0.0249837018319099 no 205 0.0285484685664816 212 262395
SGTC_1943 st076331 65.2 µM 1.90202269183509 0.0250168589365886 no 206 0.0285840940372314 230 24208415
SGTC_3053 9095903 49.47 µM 1.89915261595208 0.0251919785237617 no 207 0.0287722063883728 188 17174018
SGTC_1240 0356-0016 42.1 µM 1.89425872326865 0.0254929516028509 no 208 0.0290953384747861 262 4305613
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.88735236936846 0.025922809041342 no 209 0.0295564735014494 257 390807
SGTC_1728 st035614 33.7865 µM 1.88241767502364 0.0262336492850818 no 210 0.029889663967714 344 15945546
SGTC_2200 6600604 21.907 µM 1.88090530824823 0.0263295360486326 no 211 0.0299924005057412 291 2904777
SGTC_2253 7938677 135.83 µM 1.8790047678054 0.0264504489435002 no 212 0.0301219211060207 229 2301972
SGTC_2265 7929201 200 µM 1.87719497215686 0.0265660195952355 no 213 0.0302456881928631 259 1265108
SGTC_1816 st051957 91.6 µM 1.87393248470259 0.026775422532741 no 214 0.0304698656908686 224 674121
SGTC_199 4063-0024 41.6 µM 1.86777134531577 0.0271746353577692 no 215 0.0308969745763801 214 306215
SGTC_3283 9109332 35.8195 µM 1.86638920457266 0.0272648702821323 no 216 0.0309934661927372 200 17027281
SGTC_1273 0849-0096 14.1 µM 1.86378589769942 0.0274355094526949 no 217 0.0311758884637763 263 5286025
SGTC_2445 5742597 35.57 µM 1.86161446115519 0.0275785211043813 no 218 0.0313287267183 240 1774255
SGTC_1548 st061468 90.8 µM 1.85931906456302 0.0277303719041486 no 219 0.031490963135026 219 390799
SGTC_1424 4048-1941 275 µM 1.85719682669189 0.0278713867361556 no 220 0.0316415781545174 284 X1424
SGTC_3118 9124250 49.47 µM 1.84795049357857 0.0284927604406752 no 221 0.0323047524726583 232 1504786
SGTC_3179 9107801 49.47 µM 1.84473880026471 0.0287112722217622 no 222 0.0325377718963769 251 4818259
SGTC_2818 7996756 12.99 µM 1.84144711127807 0.0289366707687408 no 223 0.0327780321699582 179 2241621
SGTC_1280 0880-0253 10.1 µM 1.83144818757107 0.0296303831681422 no 224 0.0335168372338519 278 6836607
SGTC_1761 st044296 37 µM 1.82957962114566 0.0297615404823218 no 225 0.0336564116670371 261 1826700
SGTC_2433 5607874 27.82 µM 1.82240466800212 0.0302696440667504 no 226 0.034196803410713 303 2252428
SGTC_2681 menadione 3.18 µM 1.82186592501175 0.0303080842855954 no 227 0.0342376658630604 269 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2972 9093619 59.92 µM 1.82133632856078 0.0303459113047962 no 228 0.0342778736814732 281 25236256
SGTC_3095 9117207 49.47 µM 1.81865763967528 0.0305378394885956 no 229 0.0344818390829811 193 17015229
SGTC_2495 cafestol 54.53 µM 1.81595378166952 0.0307325896320372 no 230 0.0346887311140828 280 16667697 An anti-infammatory.
SGTC_150 3970-0969 77.2 µM 1.81268493091017 0.0309694063205636 no 231 0.0349402149900982 372 6615640
SGTC_2754 granisetron 64.02 µM 1.8112009598842 0.0310774121085682 no 232 0.0350548748444092 305 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1291 0993-0025 5.79 µM 1.80792510220023 0.0313169378283729 no 233 0.03530907915197 254 4353356
SGTC_2890 9046729 58.44 µM 1.80444771328317 0.0315728675560354 no 234 0.035580574476093 250 903329
SGTC_3099 9120367 49.47 µM 1.8043332313822 0.0315813225286237 no 235 0.0355895416065472 257 24824940
SGTC_2361 9034121 116 µM 1.80392672080168 0.0316113601756069 no 236 0.0356213977086991 263 6496917
SGTC_2368 9071271 200 µM 1.79837962580455 0.032023607422794 no 237 0.0360584346008449 300 27209959
SGTC_1874 staurosporine 7.6 µM 1.79821531515999 0.0320358859860806 no 238 0.0360714467488553 308 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1825 st052143 62.6 µM 1.79600455296167 0.0322014695952091 no 239 0.0362468964650526 237 674173
SGTC_1150 3909-7983 10.9 µM 1.78141479107506 0.0333120247413769 no 240 0.0374223568300333 330 23965914
SGTC_3103 9120822 49.47 µM 1.77803139715708 0.0335740204959311 no 241 0.0376993491990586 282 17141819
SGTC_2462 5162487 171.77 µM 1.77711298781591 0.0336454301935347 no 242 0.037774825845488 277 2259986
SGTC_1272 0839-0021 27 µM 1.7764779623979 0.0336948788081389 no 243 0.0378270855418177 300 5027250
SGTC_3035 9091303 49.47 µM 1.77382507628093 0.0339021028346818 no 244 0.0380460444473823 228 25237002
SGTC_1218 1348-1416 30.7 µM 1.77367258517739 0.0339140461124756 no 245 0.0380586618278856 282 6787668
SGTC_2241 6772625 37.8075 µM 1.77009848222797 0.0341949665207737 no 246 0.038355368179244 296 2285411
SGTC_2122 5258151 111.688 µM 1.76414766543429 0.0346669360112243 no 247 0.0388535605978883 306 2173356
SGTC_2973 9094665 17.96 µM 1.76121482318372 0.0349015054342107 no 248 0.0391010250442536 357 25237061 YIL048W NEO1
SGTC_1608 st001473 40.5 µM 1.75905986610706 0.0350746884926128 no 249 0.0392836703808621 314 7292267
SGTC_2745 rifampicin 24.3 µM 1.7539522738668 0.0354879774978478 no 250 0.0397193426710948 164 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_66 0109-0187 42.4 µM 1.7430017027946 0.0363875231758826 no 251 0.0406666586897187 311 759417
SGTC_1633 st005664 67.9 µM 1.74100097107194 0.0365538746395332 no 252 0.0408417041531396 338 2063822
SGTC_273 hydroxyurea 18.1 mM 1.7409694931987 0.0365564968405294 no 253 0.0408444630517335 368 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_401 neomycin 50 µM 1.73502338083028 0.037054593024397 no 254 0.0413683319912076 268 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1226 3909-7979 35.4 µM 1.73131503269035 0.0373680342405463 no 255 0.041697795854479 360 6615510
SGTC_2083 5306046 65.942 µM 1.73047011040593 0.0374397518265288 no 256 0.0417731584921857 345 539837
SGTC_2937 9044753 11.33 µM 1.72870101903055 0.0375902776360184 no 257 0.0419313094427354 366 6465530 YGL099W LSG1
SGTC_2325 6158266 200 µM 1.72446133922165 0.0379530288527595 no 258 0.0423122962298673 322 3623240
SGTC_2744 captopril 92.04 µM 1.7227727491385 0.0380982993402769 no 259 0.0424648142925481 221 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_425 3825-7017 13.1 µM 1.72081891456754 0.0382669546469947 no 260 0.0426418445215425 358 3397440
SGTC_1049 3226-0134 66 µM 1.71042470289286 0.039174446366512 no 261 0.043593683119247 363 5702385
SGTC_2006 4011487 200 µM 1.71015412258606 0.0391983019643041 no 262 0.0436186883609762 401 45595294
SGTC_1434 4073-0095 163 µM 1.70360246574359 0.0397795441204856 no 263 0.0442276902582648 299 24133745
SGTC_1427 4048-4900 550 nM 1.70281028769086 0.0398502960394547 no 264 0.0443017884935168 314 24132586
SGTC_266 formosanin C 406 nM 1.68673730456769 0.0413080484556221 no 265 0.0458269377910619 371 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2034 5197015 53.07 µM 1.68668758937926 0.0413126235818981 no 266 0.0458317198563225 310 780676
SGTC_1176 0848-0131 83.3 µM 1.68405967112145 0.0415550475793883 no 267 0.0460850686408751 353 6769040
SGTC_3332 9141069 11.198 µM 1.68336175525952 0.0416196232534841 no 268 0.0461525410779616 283 17332883
SGTC_1352 1496-0991 99 µM 1.68240287654653 0.041708477436743 no 269 0.0462453719898809 325 3000039
SGTC_1936 st074407 74.3 µM 1.68233795284345 0.0417144991199279 no 270 0.0462516627955052 385 809813
SGTC_1660 st012960 28.1 µM 1.6782557628613 0.0420945391448917 no 271 0.0466485899807286 364 24207266
SGTC_3205 9113483 49.47 µM 1.6704065108792 0.0428331541588516 no 272 0.0474194811710794 377 17018033
SGTC_1364 1653-0028 37.6 µM 1.66629146815273 0.0432245448572434 no 273 0.0478276876188397 349 5718652
SGTC_2953 9074162 66.49 µM 1.66218932689071 0.0436175781250546 no 274 0.0482374096809931 293 16451992
SGTC_3193 9111931 49.47 µM 1.65685444420699 0.044133031306405 no 275 0.0487744532772684 339 17087244
SGTC_206 4546-0025 72.014 µM 1.65650043219713 0.044167408756894 no 276 0.0488102588035711 418 6620745 YIL048W NEO1
SGTC_255 tunicamycin 200.472 nM 1.65292807393471 0.0445155232214462 no 277 0.0491727513801735 377 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2995 9067767 71.4286 µM 1.65258037363496 0.0445495231766349 no 278 0.049208147567599 294 11673567
SGTC_1513 0337-0559 19 µM 1.64923906608907 0.0448773212309286 no 279 0.0495493337467028 315 775073
SGTC_1359 1582-0056 520 nM 1.64830246744475 0.0449695536027157 no 280 0.0496453093338166 381 3661189
SGTC_2934 9036370 36.88 µM 1.64763617718517 0.0450352599545985 no 281 0.0497136760059026 389 6462800
SGTC_2252 omeprazole 400 µM 1.6449781370671 0.0452981524738135 no 282 0.0499871598844029 235 4594 A proton pump inhibitor.
SGTC_596 1155-0152 116 µM 1.6439810770793 0.0453970841681545 no 283 0.0500900555875915 418 280313
SGTC_1086 cerivastatin 2.18 µM 1.63961554789022 0.0458322947888317 no 284 0.0505425641381621 302 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3174 9107204 49.47 µM 1.63907878311964 0.0458860369293567 no 285 0.0505984265578988 353 3938802
SGTC_3312 9133330 71.43 µM 1.63842568170808 0.0459514952419778 no 286 0.0506664627278878 341 17617324
SGTC_1870 st057514 26.5 µM 1.63670898986721 0.0461239117244173 no 287 0.0508456448361256 341 5393161
SGTC_2971 9092186 9.93 µM 1.63154618036579 0.0466455730295373 no 288 0.0513875619303337 329 25236400
SGTC_2078 5212016 200 µM 1.62999546141998 0.0468031822170496 no 289 0.0515512281055395 303 1899708
SGTC_1358 1509-0022 2.48 µM 1.62369874057636 0.0474475508748306 no 290 0.0522200599787289 359 3258434
SGTC_1975 st070967 30.8 µM 1.62333982742702 0.047484492959428 no 291 0.0522583900400109 403 261391
SGTC_651 3253-0966 34.4 µM 1.62251563073695 0.0475694127985053 no 292 0.0523464945311248 387 781462
SGTC_161 4065-0411 162.148 µM 1.62012876616699 0.0478160261449345 no 293 0.052602309628091 445 1906281 YLR208W SEC13
SGTC_2827 7993847 71.43 µM 1.61956734036259 0.0478741816987637 no 294 0.0526626250158286 305 2985692
SGTC_2053 5265679 138 µM 1.61391972344138 0.048462347677449 no 295 0.0532724199571696 383 764595
SGTC_1360 1598-0022 39.8 µM 1.60552347660147 0.0493474333109179 no 296 0.0541893254504217 454 761525
SGTC_2389 9091542 195.52 µM 1.60206685166131 0.04971554124714 no 297 0.0545704136054577 410 3626624 YOL127W RPL25
SGTC_1009 4106-0057 9.87 µM 1.60083446667551 0.0498473107412889 no 298 0.0547067937330543 379 2928005
SGTC_1723 st034307 2.5525 µM 1.5989611234578 0.0500481464189748 no 299 0.0549146205554117 365 867466
SGTC_358 0075-0058 9.45 µM 1.5970119986175 0.0502577907551302 no 300 0.055131516330507 493 1069125
SGTC_1381 2324-0066 62.1 µM 1.58792540305587 0.0512443817299484 no 301 0.0561516042117245 396 10885928
SGTC_2803 7707263 71.43 µM 1.58621675126302 0.0514316110173835 no 302 0.0563450745601979 342 2199229
SGTC_1268 0828-0275 2.46 µM 1.58258156353409 0.0518317546540357 no 303 0.0567584341893656 367 745337
SGTC_2235 salicylic acid 500 µM 1.58183980874063 0.0519137065234938 no 304 0.0568430723211288 307 338 A COX inhibitor and kinase inhibitor.
SGTC_992 3909-8734 162 µM 1.58080397148874 0.0520283219837278 no 305 0.0569614330980433 366 4288319
SGTC_138 0850-0259 40.9225 µM 1.58034509273676 0.0520791611626182 no 306 0.0570139292343343 562 6813004
SGTC_3303 9125618 40.5795 µM 1.57969522617054 0.052151227391032 no 307 0.0570883397074832 472 22695467
SGTC_2809 7964133 12.99 µM 1.57830716231846 0.0523054204510332 no 308 0.0572475306445638 428 1253665
SGTC_1667 st014849 34.6 µM 1.57369912557471 0.0528199011937492 no 309 0.0577785120491181 369 5348460
SGTC_1704 st028805 70.8 µM 1.570261583589 0.0532063059450896 no 310 0.0581771338219102 356 2876101
SGTC_897 1000-0139 31.4 µM 1.56732506356744 0.0535381639845312 no 311 0.0585193649215599 364 6151020
SGTC_33 0986-0033 35.816 µM 1.56624655878786 0.0536604574650228 no 312 0.0586454533590718 342 2848082
SGTC_2317 5986382 200 µM 1.56225465658806 0.0541150321918523 no 313 0.0591140046542241 362 877883
SGTC_735 3076-0345 636 µM 1.55176789626622 0.0553237299411114 no 314 0.06035888507209 454 2888990
SGTC_178 4092-0806 87.505 µM 1.54736282292195 0.0558377722980803 no 315 0.0608878903380154 511 2169044
SGTC_2354 9060492 162 µM 1.54540525092825 0.0560674138059673 no 316 0.0611241355028125 435 6471895
SGTC_2393 9031399 185.94 µM 1.53950616555279 0.0567639378763356 no 317 0.0618403869276777 403 1526623 YDL150W RPC53
SGTC_2143 5623677 140.463 µM 1.53774607945477 0.056973071802135 no 318 0.0620553560664074 327 5375313
SGTC_2602 kawain 100 µM 1.53721273257472 0.0570365638578272 no 319 0.0621206116777657 453 5369129
SGTC_2575 plumbagin 510 nM 1.53377888018068 0.057446680200486 no 320 0.0625420302213098 412 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2591 skatole 100 µM 1.5304817745278 0.0578426441491922 no 321 0.0629487606769265 391 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1653 st012112 65 µM 1.52755821891977 0.0581955386945331 no 322 0.063311131005694 375 720429
SGTC_3354 9151612 71.43 µM 1.52034466091778 0.0590735041312097 no 323 0.0642121874739274 426 27261949
SGTC_2652 actinonin 100 µM 1.51851900946156 0.0592973443425561 no 324 0.0644418055206982 350 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2963 9082507 9 µM 1.51716588529436 0.0594636774462617 no 325 0.0646124035552961 395 16459611
SGTC_1801 st050089 28.441 µM 1.51506297691733 0.0597229035437901 no 326 0.0648782281914991 538 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2218 6965428 192.983 µM 1.51346088373545 0.0599209875814662 no 327 0.0650813149562236 389 675684
SGTC_671 0560-0003 407 µM 1.50768191706398 0.0606397817362513 no 328 0.0658179778923461 403 3238678
SGTC_2046 4110841 106 µM 1.50248923915641 0.0612913895773978 no 329 0.0664854024803968 402 44119630 YMR134W ERG29
SGTC_776 4476-4378 112 µM 1.50230915441222 0.0613140854427706 no 330 0.0665086427686777 386 2892008
SGTC_1045 1348-1485 165 µM 1.49890237246338 0.0617446762625395 no 331 0.0669494804147711 483 6810614
SGTC_3047 9092122 49.47 µM 1.49628935754757 0.06207653796928 no 332 0.0672891336180582 419 17173831
SGTC_2664 lyso-paf C-16 73.48 µM 1.49601187952006 0.062111860196591 no 333 0.0673252797478801 438 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2106 5357045 167.29 µM 1.49588255303698 0.0621283284760789 no 334 0.0673421318013054 442 668842
SGTC_1196 1588-0294 184 µM 1.49328753364352 0.0624594955835377 no 335 0.067680968696358 387 6144269
SGTC_3279 9140807 49.47 µM 1.49265091350766 0.0625409486411847 no 336 0.0677642943176942 400 45595718
SGTC_1627 st003713 25.6 µM 1.4924783726813 0.0625630388223152 no 337 0.0677868913988242 533 16195070 YER133W GLC7
SGTC_2313 7726885 200 µM 1.49094957612421 0.0627590344849606 no 338 0.0679873669773146 428 726423
SGTC_946 3434-1334 87.4 µM 1.48886218904121 0.0630274151558332 no 339 0.068261831025965 429 4047976
SGTC_3088 9117578 49.47 µM 1.48739832853629 0.0632161601034713 no 340 0.0684548190524676 387 678341
SGTC_582 0987-0078 156 µM 1.48472215302158 0.063562354043291 no 341 0.0688087204425818 593 1625765
SGTC_88 0180-0332 8.668 µM 1.48452399965383 0.063588045997747 no 342 0.0688349805233563 426 3101745
SGTC_2729 fluphenazine 10.66 µM 1.48384723458893 0.0636758542004028 no 343 0.0689247264109494 451 3372 An atypical antipsychotic.
SGTC_1871 st057448 67.3 µM 1.47336215175249 0.0650483462057718 no 344 0.0703267050412082 458 691747
SGTC_2057 5236571 38.335 µM 1.46777530703562 0.0657889793369397 no 345 0.0710826334998264 493 54684039 YBR257W POP4
SGTC_195 4234-0266 16.654 µM 1.4676238229836 0.0658091518150065 no 346 0.0711032166093526 497 2303354
SGTC_3227 9130768 49.47 µM 1.46592341791633 0.0660359164939943 no 347 0.0713345756876714 389 17720899
SGTC_2304 7443016 91.4 µM 1.46548762923727 0.0660941302761402 no 348 0.0713939625233226 389 939854
SGTC_730 1436-0052 41.2 µM 1.46422482809169 0.0662630430527423 no 349 0.0715662642769878 385 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_816 0325-0417 81.3 µM 1.46221358644852 0.0665327575366394 no 350 0.0718413448309025 392 68101
SGTC_2926 9010726 65.15 µM 1.45884983681256 0.0669857462575636 no 351 0.0723032211531578 461 2994293
SGTC_581 0958-0271 211 µM 1.45864138658765 0.0670138960923806 no 352 0.0723319181469764 546 4591145
SGTC_404 fumagillin 50 µM 1.45721004466091 0.0672074366016327 no 353 0.0725292043655088 479 12015870 A methionine aminopeptidase binder.
SGTC_1129 3453-1384 223 µM 1.45680947867003 0.0672616769054739 no 354 0.0725844893462514 496 1084452
SGTC_3030 9087619 49.47 µM 1.45594372810451 0.067379023072653 no 355 0.0727040880415833 417 25236973
SGTC_1314 1222-0010 41.1 µM 1.45372664289331 0.0676802542765855 no 356 0.0730110542377244 433 3526027
SGTC_1666 st014829 29 µM 1.45340398747702 0.067724179448765 no 357 0.0730558100061599 475 3858230
SGTC_2120 5538279 151.968 µM 1.45031412124187 0.068145938884765 no 358 0.0734854714806556 436 2058197
SGTC_47 0149-0135 24.25 µM 1.44962121442994 0.068240796750398 no 359 0.0735820884014703 420 5239155
SGTC_2299 7976368 114.88 µM 1.44333841672321 0.0691055590089024 no 360 0.0744625814120234 434 2979718
SGTC_2630 antimycin a 100 µM 1.44327320561942 0.0691145787188202 no 361 0.0744717623134333 493 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2802 7925815 54.55 µM 1.43892206894505 0.0697184606915365 no 362 0.0750863020000482 489 1262923
SGTC_741 4582-0002 126 µM 1.43783225001598 0.0698703477858189 no 363 0.0752408282422796 468 2912688
SGTC_2907 7721985 69.9 µM 1.43606934948095 0.0701165806220961 no 364 0.0754913043573658 451 3267881
SGTC_2710 st078562 53.7235 µM 1.43437895803369 0.0703533121385959 no 365 0.0757320745242083 435 17250908
SGTC_1955 wogonin 32.4 µM 1.43305365712775 0.0705393438363108 no 366 0.0759212519111598 431 5281703 A flavanone.
SGTC_1103 duloxetine 36.1 µM 1.43135346049503 0.0707785528321593 no 367 0.076164469693632 515 60835 A selective serotonin reuptake inhibitor.
SGTC_1503 4585-0012 61.3 µM 1.42876999905565 0.0711432251166118 no 368 0.0765351755483912 427 2922052
SGTC_633 0437-0093 97.7 µM 1.42719171722808 0.0713667186810145 no 369 0.076762320642061 434 2831118
SGTC_390 dec-rvkr-cmk 16.7 µM 1.4270008572308 0.0713937820120478 no 370 0.0767898237694811 486 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2561 acetosyringone 100 µM 1.42565625712561 0.0715846652315494 no 371 0.0769837944267585 531 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_11 0438-0307 1.3 µM 1.42465978854137 0.0717263791671347 no 372 0.0771277840775492 440 4011476
SGTC_3200 9114385 49.47 µM 1.42444454914491 0.0717570179307771 no 373 0.0771589130167825 429 17018030 YLR208W SEC13
SGTC_2529 gangaleoidin 93.61 µM 1.42340465404907 0.0719051856995898 no 374 0.0773094420526957 423 4565183
SGTC_3235 9132602 49.47 µM 1.41852252349863 0.0726039461892988 no 375 0.0780191337952905 501 4912240
SGTC_694 1315-0438 43.2 µM 1.41624128949811 0.0729322279398872 no 376 0.0783524353850226 403 6793154
SGTC_223 busulfan 5 mM 1.41315369816009 0.0733783568996064 no 377 0.0788052686225796 368 2478 A DNA alkylator.
SGTC_3238 9133470 49.47 µM 1.40828304896138 0.0740863609206935 no 378 0.0795236364940403 444 3534688
SGTC_2477 5967686 25.23 µM 1.40671945228506 0.0743147504857291 no 379 0.079755297631548 477 776118
SGTC_2936 9038235 15.59 µM 1.40568965779436 0.0744654626672172 no 380 0.0799081496757866 468 4749415
SGTC_1860 st056228 74.6 µM 1.40139223316795 0.0750969176323256 no 381 0.0805484067783834 458 688679
SGTC_1545 lovastatin 49.4 µM 1.40065838669971 0.0752051545456065 no 382 0.0806581260869512 529 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1951 sophoraflavanone G 9.2 µM 1.39708037908317 0.0757345885086856 no 383 0.0811947006831833 536 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1398 3558-0053 112 µM 1.39686269563358 0.0757668902819393 no 384 0.081227432207897 397 4532369
SGTC_1297 1068-0111 14.1 µM 1.39681655074768 0.0757737390113399 no 385 0.081234371967541 452 767057
SGTC_2994 9053520 71.4286 µM 1.39485730270309 0.0760649618275047 no 386 0.0815294374432793 489 4647384
SGTC_1604 st002052 72.4 µM 1.39132781474184 0.0765917342344229 no 387 0.0820630214930515 485 6254834 YHR062C RPP1
SGTC_1734 st037168 69.4 µM 1.38851931585599 0.0770128785038858 no 388 0.0824894835629841 482 708907
SGTC_2270 7924575 90.91 µM 1.3849581020299 0.0775494229328398 no 389 0.083032639556325 507 1262135
SGTC_252 miconazole 1.30953 nM 1.37776084890675 0.0786424435249017 no 390 0.0841385687371266 476 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_29 0299-0004 12.984 µM 1.3763859631359 0.0788525642395908 no 391 0.0843510857159478 391 16871 A napthoquinone isolated from Swertia calycina.
SGTC_260 nsc-65238 3.989 µM 1.37365234720791 0.0792715997612332 no 392 0.0847748186706963 482 3246252
SGTC_711 k292-0785 179 µM 1.37275699424098 0.0794092141386879 no 393 0.0849139521812218 497 4146315
SGTC_940 3232-1287 54.8 µM 1.36890173453177 0.0800038277109294 no 394 0.0855149967510913 504 1585493 YIL048W NEO1
SGTC_3192 9110362 49.47 µM 1.36193877147521 0.0810862774723846 no 395 0.0866086044972046 509 16649480
SGTC_2162 5663267 200 µM 1.3587170227842 0.0815908491973299 no 396 0.0871181378965211 527 6456493
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.35589128103797 0.0820353462416627 no 397 0.0875668810311355 486 5355888
SGTC_502 l-744,832 89.3 µM 1.35043401407863 0.0828989499828428 no 398 0.0884384032060676 523 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2628 lathosterol 100 µM 1.35035374063757 0.0829117039720952 no 399 0.0884512708826399 515 6710616
SGTC_2502 avocadyne acetate 18.59 µM 1.34974704763234 0.083008144192857 no 400 0.088548567707068 576 3952079
SGTC_951 1171-0579 82.7 µM 1.34542122268662 0.0836982264001679 no 401 0.0892446227503759 607 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2215 7188065 200 µM 1.34359809672916 0.0839903502433563 no 402 0.0895391926520125 435 940217
SGTC_1877 wortmannin 25 µM 1.34284769727151 0.084110810703304 no 403 0.0896606475865841 572 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1711 st032263 62.8 µM 1.3425472058849 0.0841590844694685 no 404 0.0897093175628703 494 3958979
SGTC_466 geldanamycin 89.2 µM 1.34155121625206 0.0843192383340127 no 405 0.0898707764120222 382 5288382 HSP90 inhibitor.
SGTC_1956 st077085 54 µM 1.33797316645103 0.0848964710623844 no 406 0.0904525920991657 561 24208685
SGTC_2892 9047358 58.44 µM 1.33564535146545 0.0852735957717111 no 407 0.0908326096656421 466 6466771
SGTC_3292 9120825 59.784 µM 1.33271187862741 0.085750627577215 no 408 0.0913131867914732 516 24824900
SGTC_1775 st081588 35.1725 µM 1.33169152951425 0.0859170208367486 no 409 0.0914807869151143 576 1426443 YGL099W LSG1
SGTC_124 0136-0217 7.121 µM 1.3301516333863 0.0861685964672738 no 410 0.0917341581281993 611 3976905
SGTC_2087 5276107 200 µM 1.32829117818347 0.0864732769649789 no 411 0.0920409664746734 512 144405
SGTC_440 fluspirilene 35.1 µM 1.32579663760901 0.0868830625276188 no 412 0.0924535335296629 543 3396 An atypical antipsychotic.
SGTC_2558 carylophyllene oxide 100 µM 1.31844083287929 0.0880998677491399 no 413 0.0936780596624463 575 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3013 9080133 71.4286 µM 1.30806067053017 0.0898385169000267 no 414 0.0954263659257594 595 17050193
SGTC_1369 1866-0067 208 µM 1.3073722675376 0.0899547179799552 no 415 0.09554315560579 603 3531355
SGTC_2089 5281248 129.67 µM 1.30182406718382 0.0908953237103561 no 416 0.0964882672585547 552 2737878
SGTC_2000 st075254 36.4 µM 1.30177677285058 0.0909033729301141 no 417 0.0964963530613589 495 17234175
SGTC_379 3970-0972 5.9 µM 1.30079395274624 0.0910707628826676 no 418 0.0966644962271128 538 2898042 YBL034C STU1
SGTC_2982 9019404 25.97 µM 1.29786138635011 0.0915715844121039 no 419 0.097167485447254 456 22333232
SGTC_2337 9009472 200 µM 1.29770895433242 0.0915976723296971 no 420 0.0971936827643415 600 5742383
SGTC_3146 9095609 49.47 µM 1.29760472337553 0.0916155140659176 no 421 0.097211599119787 535 17173999
SGTC_2597 laccaic acid a 100 µM 1.29617022438273 0.0918613261190461 no 422 0.097458422716617 565 5491415 A textile dye.
SGTC_836 0330-0104 1.35 µM 1.29365492475951 0.0922935200454231 no 423 0.0978923207529771 547 46494820
SGTC_1132 3456-3614 2.5 µM 1.29357184257712 0.092307821358378 no 424 0.0979066768386498 656 3125502
SGTC_2423 st077119 87.2 µM 1.29346385411536 0.0923264123533894 no 425 0.0979253388810169 553 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3311 9131146 2.8755 µM 1.29200870813008 0.0925771965669915 no 426 0.0981770644514354 566 4900406 YPR165W RHO1
SGTC_1437 4092-1038 11.6 µM 1.29139929068805 0.0926823749747025 no 427 0.0982826282350108 578 3977136
SGTC_2061 5245884 80.95 µM 1.29015797574809 0.0928968848918818 no 428 0.0984979068992768 573 573863
SGTC_1970 st070122 35.8 µM 1.2869551979767 0.0934520474566609 no 429 0.0990549521496516 561 102928
SGTC_2846 9008642 19.48 µM 1.2851045732204 0.0937739457826754 no 430 0.0993778718523776 498 2992898
SGTC_1654 st012436 41.8 µM 1.28384615094105 0.0939933032618851 no 431 0.0995978959528335 509 4323132
SGTC_1377 2944-0135 198 µM 1.28344366072771 0.0940635417939763 no 432 0.0996683429159803 570 1894137
SGTC_2386 9075165 157.42 µM 1.28072117196513 0.0945396602478686 no 433 0.100145810242592 538 16452277
SGTC_821 1114-0266 29.2 µM 1.28015991301054 0.094638035704691 no 434 0.100244450540343 544 3123235
SGTC_647 0140-0236 81 µM 1.2773190017595 0.0951371381866662 no 435 0.100744823892049 634 990837
SGTC_3213 9129884 49.47 µM 1.26871777710359 0.0966600507487005 no 436 0.102270869874064 481 17190742
SGTC_1251 0490-5699 265 µM 1.26769571674316 0.0968421979305345 no 437 0.102453317499313 638 3883818
SGTC_720 r052-1644 49.9 µM 1.26051151546295 0.0981296517866916 no 438 0.103742448211947 504 1422863 YOR257W CDC31
SGTC_1670 st016595 4.04 µM 1.25845674450728 0.098500175450932 no 439 0.104113310609127 576 597879
SGTC_788 1182-0090 188 µM 1.25726165698815 0.0987161484977682 no 440 0.104329451683467 709 5715185
SGTC_2708 st078559 56 µM 1.25543084485969 0.0990476798445482 no 441 0.104661198981936 473 17250902
SGTC_2027 5150920 200 µM 1.25434231036715 0.0992451820233658 no 442 0.104858805723537 573 786715
SGTC_635 k038-0028 24.7 µM 1.25041809244715 0.0999595768451468 no 443 0.105573429417083 594 4035102
SGTC_1335 1486-0900 202 µM 1.24335600519747 0.101254660750431 no 444 0.106868337372231 625 X1335
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.24122256957162 0.101648295933012 no 445 0.107261769733169 567 689007
SGTC_506 n9-isopropylolomoucine 153 µM 1.24038168157683 0.101803751947074 no 446 0.107417126624579 573 6610355
SGTC_294 k038-0071 157 µM 1.23807572081157 0.10223094567549 no 447 0.107843992726339 598 24152826
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.23756306520132 0.102326095261163 no 448 0.107939058341819 635 6708561
SGTC_203 k066-0004 30.888 µM 1.23698133499581 0.102434143175324 no 449 0.108047006058118 695 6795412
SGTC_86 0417-1630 471.922 µM 1.23471348346529 0.1028561556672 no 450 0.108468577969149 710 3634867
SGTC_2388 9080168 200 µM 1.22518043411826 0.104643927326855 no 451 0.110253622366992 562 15943073
SGTC_1505 k297-0037 20.6 µM 1.22344074290476 0.104972592624896 no 452 0.110581636348524 618 4089396
SGTC_2873 9040596 71.43 µM 1.22190089811525 0.105264125479934 no 453 0.110872552897372 605 6463863
SGTC_2051 5263410 176 µM 1.22144475852295 0.105350596985482 no 454 0.110958834647661 627 227584
SGTC_2912 7964298 10.93 µM 1.21435120895994 0.106701957349998 no 455 0.112306819249522 675 2975850
SGTC_364 0083-0097 67.7 µM 1.21397021170387 0.106774891819038 no 456 0.112379549727609 613 5207356
SGTC_822 1487-0950 154 µM 1.21190927189292 0.107170042077587 no 457 0.112773556271582 605 1958375
SGTC_1779 st039427 55 µM 1.20560784337797 0.108384772832563 no 458 0.11398436675992 710 1124498
SGTC_1447 4239-0816 81.9 µM 1.20540518128062 0.108424003917728 no 459 0.114023461132741 588 1341554
SGTC_1782 st039423 80.636 µM 1.20396429207467 0.108703224099323 no 460 0.11430169014358 575 2068169
SGTC_2291 7917025 104.35 µM 1.20363380903513 0.108767339015215 no 461 0.114365572980478 635 2964612
SGTC_2123 5259487 200 µM 1.20319096760418 0.108853294494531 no 462 0.11445121470022 650 2173474
SGTC_2208 7283366 200 µM 1.20051788143623 0.109373177498549 no 463 0.114969136115236 637 898663
SGTC_1845 st056753 3.01 µM 1.19812379918436 0.109840309525896 no 464 0.115434412486352 632 5375839
SGTC_3021 9087658 49.47 µM 1.19695073422764 0.110069719306654 no 465 0.115662878842768 576 25237042
SGTC_964 1287-0107 19.4 µM 1.19632328060877 0.110192567927914 no 466 0.11578521359577 671 51516812 YPR165W RHO1
SGTC_3152 9099253 49.47 µM 1.19562739420424 0.110328929931628 no 467 0.115920998141474 722 25236131
SGTC_3224 9130643 49.47 µM 1.19205193754264 0.111031464608966 no 468 0.116620440441945 603 17644395
SGTC_478 N-arachidonylglycine 10 µM 1.19013646010706 0.111409148442261 no 469 0.11699638099215 484 5283389
SGTC_3335 9143315 29.6265 µM 1.18599080086656 0.112229714427314 no 470 0.117812966201385 619 4899691
SGTC_783 0848-0141 92.7 µM 1.18437174175839 0.112551350908707 no 471 0.118132970570802 609 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.1756050084259 0.114304354680382 no 472 0.11987637661338 693 165506
SGTC_1922 5578187 25 µM 1.17026660438278 0.115381303924204 no 473 0.12094684837499 614 1350412
SGTC_575 k072-0246 11.9 µM 1.16891005993608 0.115656113375013 no 474 0.121219934974423 663 6796779
SGTC_3309 9129340 25.759 µM 1.16549032669697 0.11635094714307 no 475 0.121910286775628 698 17158987
SGTC_752 1896-0090 130 µM 1.16110096020053 0.117247127701681 no 476 0.122800422155126 654 772567
SGTC_373 0844-0104 25.9 µM 1.15894918489939 0.117688238924933 no 477 0.123238449329705 698 5375804
SGTC_2351 9026858 72.31 µM 1.1583047374919 0.117820578111535 no 478 0.123369849377807 606 1409300
SGTC_3066 9117245 49.47 µM 1.15731822126512 0.118023366062248 no 479 0.123571185858935 686 17176980
SGTC_2800 7887935 81.82 µM 1.15196489320493 0.119128099342639 no 480 0.124667749948784 640 2961002
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.15093864628973 0.119340710737351 no 481 0.124878738642327 588 77254
SGTC_574 1315-0397 40 µM 1.14977419918663 0.119582277706747 no 482 0.125118442251681 752 6794277
SGTC_2570 licareol 100 µM 1.14974256502294 0.119588845088539 no 483 0.125124958683534 654 443158
SGTC_301 4119-0100 24.5 µM 1.1488597935158 0.119772214680373 no 484 0.125306899468204 710 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1605 st000082 49.1 µM 1.14642090203627 0.120279852273444 no 485 0.125810519090192 669 1114022
SGTC_62 0180-0423 3.232 µM 1.14574237671403 0.120421351524405 no 486 0.125950882060173 638 30102 YGL099W LSG1
SGTC_1644 st010134 20.9 µM 1.14546333380901 0.120479576968014 no 487 0.126008637876981 632 3818134
SGTC_632 0781-2353 4.65 µM 1.1429735310482 0.120999980113267 no 488 0.126524790452059 703 6811515 YHR007C ERG11
SGTC_3048 9093155 49.47 µM 1.14279620643229 0.121037103643662 no 489 0.126561607117085 591 25236002
SGTC_542 3381-0244 89.3 µM 1.14261833855983 0.121074348955948 no 490 0.126598544070481 743 1112843
SGTC_1981 st071826 47 µM 1.13951801058768 0.12172484917919 no 491 0.127243580297148 630 11838600
SGTC_2082 5219693 150 µM 1.13919246084943 0.121793297117948 no 492 0.127311444693794 675 2834649
SGTC_2256 7954252 200 µM 1.13902954578837 0.121827560713657 no 493 0.127345415567283 568 2972920
SGTC_1621 st003705 32.4 µM 1.13509269248322 0.122657602495838 no 494 0.12816824151348 739 24207032
SGTC_3352 9151559 45.5865 µM 1.13151095183038 0.123416212089263 no 495 0.128920048245675 644 17159339
SGTC_1471 k673-0312 37 µM 1.12922232914998 0.1239026580311 no 496 0.129402028247132 669 24099884
SGTC_2113 5491891 107.031 µM 1.12855173453609 0.124045446551556 no 497 0.129543490555384 681 789979
SGTC_1308 1187-1617 41.4 µM 1.12853623905547 0.124048747337221 no 498 0.129546760601575 714 2882570
SGTC_660 4031-1742 102 µM 1.12804671870733 0.124153054655139 no 499 0.129650094623152 705 6738706
SGTC_2557 derrustone 83.84 µM 1.12794298695093 0.124175165762628 no 500 0.129671998936513 695 629853 An antioxidant.
SGTC_2191 5911152 200 µM 1.12660898138577 0.124459763371633 no 501 0.129953920055777 666 2875902
SGTC_289 k017-0060 526 µM 1.12660834620246 0.124459898990591 no 502 0.129954054392775 648 5512909
SGTC_3007 9078383 71.4286 µM 1.12400334627683 0.125016965910934 no 503 0.130505803178268 701 6496995
SGTC_2958 9077254 16.72 µM 1.12312168430203 0.125205899034647 no 504 0.130692908906078 644 16457351
SGTC_729 4092-0585 94.1 µM 1.11250725771862 0.127496142025837 no 505 0.132960055687709 644 2169061
SGTC_879 0831-1030 162 µM 1.11245074205653 0.127508413700877 no 506 0.132972198950449 731 1549252
SGTC_467 ro 31-8220 72.8 µM 1.11231894803459 0.127537034328904 no 507 0.133000519897498 725 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2785 7756463 72.73 µM 1.10917973938756 0.128220071141072 no 508 0.133676325547293 664 2201551
SGTC_1931 st074438 57.1 µM 1.10869338153753 0.128326120942046 no 509 0.133781239025289 660 2787313
SGTC_2318 6029776 164 µM 1.10853873694224 0.128359853785158 no 510 0.133814609657368 696 818325
SGTC_1047 2043-3044 82 µM 1.10433015058591 0.129280242846611 no 511 0.134724974214048 712 669592
SGTC_72 0744-0168 198.391 µM 1.10358338888542 0.1294440311609 no 512 0.134886950075814 678 677577
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.10306962844566 0.129556798428094 no 513 0.134998464490599 650 17037758
SGTC_1001 4048-4355 44.4 µM 1.10258712601266 0.129662766708554 no 514 0.135103251752457 697 21824233
SGTC_475 α-linolenic acid 10 µM 1.10043209135073 0.130136793080769 no 515 0.135571951274837 737 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_375 3970-0961 9.27 µM 1.09738727465422 0.130808580006697 no 516 0.136236066908523 714 2898222
SGTC_3137 9097352 49.47 µM 1.09689634970093 0.1309171182149 no 517 0.136343352318076 745 44120435
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.09601300306799 0.131112573323008 no 518 0.136536542041898 682 115019
SGTC_511 blebbistatin 171 µM 1.0948013740271 0.131380994089202 no 519 0.136801832175953 694 3476986 A myosin inhibitor.
SGTC_849 0386-0493 241 µM 1.09315264270607 0.131746858280499 no 520 0.137163392903968 685 726119
SGTC_1755 st041960 45.185 µM 1.09112572212579 0.132197607681701 no 521 0.137608782977383 709 2257073
SGTC_2437 5741531 144.16 µM 1.09050380006561 0.132336124476941 no 522 0.137745640147492 755 2262990
SGTC_1559 coumarin 343 70.1 µM 1.09022276559818 0.132398750322865 no 523 0.137807513694931 674 108770 A hepatotoxic, DNA x-linker.
SGTC_44 0929-0055 61.211 µM 1.0854120254644 0.133473945641087 no 524 0.138869604312898 655 1379590
SGTC_977 1348-1378 135 µM 1.08537111317723 0.133483115173675 no 525 0.138878660556995 735 X977
SGTC_2017 5132927 60.65 µM 1.078172376966 0.135103291960354 no 526 0.140478418391792 711 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2533 agelasine 13.65 µM 1.07159937699303 0.136594370572747 no 527 0.141950006653121 758 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1206 3978-0017 132 µM 1.07148688714412 0.136619986349023 no 528 0.141975281813508 680 3873677
SGTC_3094 9117742 49.47 µM 1.07075119540121 0.136787596368289 no 529 0.142140658310295 771 17149698
SGTC_2190 6049624 200 µM 1.07062808823408 0.136815657157112 no 530 0.142168344357239 658 2265554
SGTC_2331 7980721 200 µM 1.0698972435329 0.136982325379257 no 531 0.142332781991147 742 2981221
SGTC_322 k048-0136 19.3 µM 1.06829282992417 0.137348696351773 no 532 0.142694220887534 694 6823282
SGTC_2507 purpurin 79.67 µM 1.06666588849577 0.137720894328417 no 533 0.14306136795546 736 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1750 st081859 2.357 µM 1.06649356212806 0.137760357980127 no 534 0.143100293685683 893 5291695
SGTC_477 mead ethanolamide 10 µM 1.06564647505488 0.13795445759458 no 535 0.143291740936849 581 16061185
SGTC_1022 4477-0945 21.3 µM 1.06520847210742 0.138054893729563 no 536 0.143390800295902 732 4648966
SGTC_349 k015-0014 24 µM 1.06301604179478 0.138558377742131 no 537 0.143887338280315 684 2196908
SGTC_2085 5307070 144.047 µM 1.0625648269398 0.138662152708351 no 538 0.143989672419855 681 2840351
SGTC_599 1935-0052 86.5 µM 1.06242831622594 0.138693559255773 no 539 0.144020642298823 761 9557311
SGTC_2661 dactinomycin 12.96 µM 1.06101823994558 0.139018254152729 no 540 0.144340805989758 785 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1406 3909-7906 11.9 µM 1.05983460273644 0.139291206662225 no 541 0.144609925816722 763 X1406
SGTC_1746 st038117 42 µM 1.05908006579737 0.139465396753935 no 542 0.144781658788964 729 2898218
SGTC_1233 0325-0408 14.2 µM 1.05840449679915 0.139621482217372 no 543 0.144935535107924 742 12874
SGTC_1039 k821-0043 94 µM 1.05835551953769 0.13963280268523 no 544 0.144946695080331 769 15992768
SGTC_1408 3909-7976 48.8 µM 1.05768539346067 0.139787756452318 no 545 0.145099448302951 800 24152374
SGTC_1244 0416-0015 52.5 µM 1.05729487444964 0.139878110351681 no 546 0.145188515884762 734 96201
SGTC_2641 levomentholum 100 µM 1.05508734553291 0.140389609883824 no 547 0.145692689504092 710 16666
SGTC_1952 st077036 64.1 µM 1.05463044529137 0.140495635229023 no 548 0.145797186978249 743 2937007
SGTC_2950 9072895 21.46 µM 1.05439641446503 0.14054996397224 no 549 0.145850731582096 741 17332245
SGTC_2418 pentamidine 31.67 µM 1.05235730496391 0.141023933489808 no 550 0.146317824662744 699 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_868 0527-0199 213 µM 1.05060026166806 0.141433208202782 no 551 0.146721110423449 772 2849450
SGTC_1304 1165-0502 251 µM 1.04954934075564 0.141678387510919 no 552 0.146962679399072 783 767425
SGTC_1965 Pectolinarigenin 58.4 µM 1.04874463825999 0.14186631870646 no 553 0.147147831824154 758 5320438 An anti-inflammatory.
SGTC_274 sirtinol 40.1 µM 1.04838352512795 0.14195070835175 no 554 0.147230970453285 759 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_802 4112-3352 742 µM 1.04451132793735 0.1428577501963 no 555 0.148124440483792 804 704594
SGTC_1445 4239-0156 97.7 µM 1.04289809420185 0.14323679520204 no 556 0.14849774619665 846 4008346
SGTC_1699 st031318 29.054 µM 1.04240640074286 0.143352458320814 no 557 0.148611650093705 761 5340658
SGTC_790 1575-0012 79.1 µM 1.03946945567916 0.14404464145946 no 558 0.149293228188957 784 378741 YLR208W SEC13
SGTC_9 0092-0002 10.449 µM 1.03235344457089 0.145731085831355 no 559 0.150953286428197 781 759368
SGTC_1712 st032288 53.4 µM 1.02988391118731 0.146319437774483 no 560 0.151532252059541 878 2883011
SGTC_1685 st024049 53.0905 µM 1.02958444454754 0.146390892238672 no 561 0.151602560246777 739 1941139
SGTC_1947 st076332 61.6 µM 1.02777028679058 0.146824261514693 no 562 0.152028948151621 729 24208416
SGTC_515 4092-1064 102 µM 1.02764081953498 0.146855221753168 no 563 0.152059407717996 838 717353
SGTC_636 0kpi-0074 126 µM 1.02464285766364 0.147573366188251 no 564 0.152765867242777 741 616434
SGTC_165 k038-0023 64.381 µM 1.02256524744914 0.148072423493708 no 565 0.153256724037106 782 46368543
SGTC_385 1494-0393 12.4 µM 1.02099648436982 0.148449999516248 no 566 0.153628052175811 805 3090647
SGTC_1252 0493-0875 34.8 µM 1.02074993710541 0.148509397970388 no 567 0.153686464338178 746 3960963
SGTC_3355 9151058 44.0485 µM 1.02026561346375 0.148626128054316 no 568 0.153801253465752 759 17015728
SGTC_941 3237-0776 460 µM 1.01931745099317 0.148854828581257 no 569 0.154026140893014 758 760008
SGTC_1581 himbacine 57.9 µM 1.01930162719274 0.148858647338322 no 570 0.154029895864389 785 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1234 0326-0494 15.5 µM 1.017550907797 0.149281552685756 no 571 0.154445713798514 791 1547813
SGTC_893 0958-0369 48.9 µM 1.015744530098 0.149718742987015 no 572 0.154875528430317 808 6819948
SGTC_3157 9099274 49.47 µM 1.01503325152526 0.149891125023334 no 573 0.155044988669948 770 17217662
SGTC_1485 3909-9022 254 µM 1.01448254598984 0.150024682235989 no 574 0.155176276871486 806 714516
SGTC_2647 atorvastatin 60.16 µM 1.01337780391208 0.150292843666006 no 575 0.155439868604767 769 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2292 7671323 168.05 µM 1.01146993821671 0.150756704378828 no 576 0.155895781094448 794 937504
SGTC_713 1488-1073 324 µM 1.01144142455584 0.150763644146709 no 577 0.155902601530931 800 3312542
SGTC_2312 7706453 155.7 µM 1.01047574283878 0.150998801176186 no 578 0.156133707681939 753 976098
SGTC_2654 protoveratrine a 100 µM 1.01023252485593 0.151058066624193 no 579 0.156191949977519 779 5702278 A heart drug and vasodilator.
SGTC_92 0063-0024 660.874 µM 1.00904066106012 0.151348714383579 no 580 0.156477567053595 879 3594437
SGTC_627 1391-0720 175 µM 1.00802035125489 0.151597822287105 no 581 0.156722346152667 771 997839
SGTC_1539 benzyladenosine 56 µM 1.00742625089827 0.151742996942731 no 582 0.156864990806137 768 92208 A nucleotide analog.
SGTC_2522 biochanin a 4.94 µM 1.00299952829835 0.152827621195469 no 583 0.157930544420131 766 5280373 A possible chelator.
SGTC_1562 morin hydrate 59.1 µM 1.00218886881213 0.153026802503079 no 584 0.158126191417262 783 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1161 k007-0610 110 µM 1.00082580718609 0.153362098332587 no 585 0.158455515275191 884 5843850
SGTC_3049 9092223 49.47 µM 0.999645511010879 0.153652829077581 no 586 0.158741045092305 763 8623917
SGTC_1465 k213-0056 144 µM 0.994686599845389 0.154878293803077 no 587 0.159944356885949 779 24048857 YMR208W ERG12
SGTC_1326 1431-2094 10.8 µM 0.994523423415422 0.154918727985396 no 588 0.159984053818146 803 616278
SGTC_2505 galangin 7.89 µM 0.989397872879853 0.156192358892077 no 589 0.161234257428532 731 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2656 pseudo-anisatin 100 µM 0.985821374227793 0.157085145965844 no 590 0.162110387567232 827 6708809 A neurotoxin.
SGTC_1285 0929-0069 65.5 µM 0.983214103376508 0.157738099661677 no 591 0.162751037493892 809 1206237
SGTC_1040 k898-0338 155 µM 0.982931181464055 0.157809060479301 no 592 0.162820655029805 882 20969351
SGTC_1911 st060208 74.3 µM 0.981810528745588 0.158090341996181 no 593 0.163096600091858 836 688783
SGTC_766 1391-0721 126 µM 0.980633146054788 0.158386216909511 no 594 0.163386841353216 833 1020919 YIL115C NUP159
SGTC_2862 9027634 71.43 µM 0.979318150587331 0.158717102921004 no 595 0.163711402459057 736 5012562
SGTC_2900 5328528 85.29 µM 0.978298624775224 0.15897395298009 no 596 0.163963324944608 870 795359
SGTC_319 1348-1596 45.5 µM 0.976460107100516 0.159437820454034 no 597 0.164418253853416 857 5380505
SGTC_607 4491-0986 66.8 µM 0.975739907477335 0.159619771827599 no 598 0.164596685265556 862 698981 YDR232W HEM1
SGTC_3326 9140064 16.379 µM 0.974016462996259 0.160055734639014 no 599 0.16502418253247 800 1868434
SGTC_329 k048-0121 21.3 µM 0.97340192461027 0.160211376507638 no 600 0.165176791375005 803 6832902
SGTC_3203 9113543 49.47 µM 0.971317880705387 0.160739931007066 no 601 0.165695003692199 776 17018012
SGTC_3188 9110789 49.47 µM 0.970127087486504 0.161042450177767 no 602 0.1659915742999 832 849217
SGTC_169 k015-0017 16.025 µM 0.969824345307289 0.161119420560982 no 603 0.166067027799787 761 1840002
SGTC_577 r071-0003 38.6 µM 0.969643782564046 0.161165338981395 no 604 0.16611204063674 968 4568517 YMR134W ERG29
SGTC_1933 st074711 15.9 µM 0.969291654601958 0.161254912245571 no 605 0.166199845972978 856 17250958
SGTC_701 4424-0219 185 µM 0.968415117120565 0.16147802425117 no 606 0.166418546314483 912 2911779
SGTC_576 1073-0113 22.7 µM 0.967616918107521 0.161681371167626 no 607 0.166617862396422 1039 5439563
SGTC_221 trifluoperazine 10.304 µM 0.966625367153977 0.161934208217582 no 608 0.166865674335637 961 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_153 4077-0274 519.67 µM 0.963919193232563 0.162625569585092 no 609 0.167543220193733 796 3121976
SGTC_1904 st060225 78 µM 0.963406309399497 0.162756815020246 no 610 0.16767183062083 829 66595
SGTC_36 0335-0881 14.2 µM 0.963272906302436 0.162790963759268 no 611 0.167705293114386 876 23828853
SGTC_1615 st002656 86.5 µM 0.962062305440757 0.163101068301456 no 612 0.168009153730872 835 1584458
SGTC_1767 st044992 70.3 µM 0.960621428973342 0.163470659776131 no 613 0.168371275028765 811 9600693
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.957995742132617 0.164145558182129 no 614 0.169032452806999 884 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2962 9082311 13.18 µM 0.956025346887806 0.164653207724751 no 615 0.169529714431741 787 16459453
SGTC_118 0083-0097 135.343 µM 0.955648943908012 0.164750299200575 no 616 0.169624812576997 1025 5207356
SGTC_1475 4092-1048 11.7 µM 0.954538175803385 0.165037033066612 no 617 0.169905647391963 879 2881759
SGTC_17 0960-0276 49.807 µM 0.95203076172103 0.165685484484155 no 618 0.170540690611401 893 6821114
SGTC_256 clotrimazole 625 nM 0.948532614409814 0.166592901593694 no 619 0.17142918874031 837 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_907 3448-6986 75.5 µM 0.947953630166219 0.166743398526932 no 620 0.17157653041686 917 590582
SGTC_3236 9132701 49.47 µM 0.946601404011546 0.167095227885115 no 621 0.171920964120119 843 24282524
SGTC_2382 9035899 200 µM 0.94600544806408 0.167250438710601 no 622 0.172072903728538 865 6462679
SGTC_1028 k015-0029 4.8 µM 0.9436046249675 0.167876650221777 no 623 0.17268586397127 852 4588309
SGTC_3272 9137413 49.47 µM 0.940446161177404 0.168702774602243 no 624 0.173494376799343 833 17614870
SGTC_2227 7312221 64.1025 µM 0.93946370023477 0.168960277886525 no 625 0.173746360502684 885 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1303 1160-0052 261 µM 0.937624704295549 0.169442957439576 no 626 0.174218655534 895 3562476
SGTC_1048 3161-0300 24.5 µM 0.936866261422992 0.169642282707245 no 627 0.174413677928572 898 2165101
SGTC_2977 9011197 71.43 µM 0.935187438183394 0.170084026503085 no 628 0.174845855563123 793 2704722
SGTC_2996 9066192 71.4286 µM 0.932741317531085 0.17072898535236 no 629 0.175476773213069 848 6472854
SGTC_452 diindolylmethane 8 µM 0.932180959478531 0.170876952804524 no 630 0.17562150691806 802 3071 Inhibits expression of several cancer promoting factors.
SGTC_1575 cyproterone acetate 48 µM 0.930619278276035 0.171289761262727 no 631 0.176025269314153 850 9880 An androgen receptor antagonist and liver toxin.
SGTC_1385 3091-4834 14.1 µM 0.929375733365125 0.171618930459283 no 632 0.176347199644515 833 4072814
SGTC_187 1488-2104 32.728 µM 0.927843485611437 0.172025075346137 no 633 0.176744381641468 923 2852859
SGTC_984 1492-0255 2.91 µM 0.926792473299324 0.172304016154093 no 634 0.177017146807771 838 1585198
SGTC_328 k915-0120 63.5 µM 0.92352350462491 0.173173450447734 no 635 0.17786722860291 879 6624543
SGTC_249 wiskostatin 11.211 µM 0.921976448065684 0.17358588709926 no 636 0.178270430371467 897 2775510 A n-wasp and actin depolymerizer.
SGTC_1849 st056239 19.2 µM 0.918979252376958 0.1743866995876 no 637 0.179053212208989 858 5393181
SGTC_1900 st060200 72.8 µM 0.915797722751295 0.175239327381377 no 638 0.179886499071725 889 688945
SGTC_2417 cerulenin 830 nM 0.915459796663538 0.175330044276203 no 639 0.179975149481022 872 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2314 7727897 200 µM 0.914886688778555 0.175483964225171 no 640 0.180125559407885 882 900724
SGTC_2173 5763948 167 µM 0.912888101714044 0.176021395888555 no 641 0.180650697938647 909 2867177
SGTC_1895 st058434 18.3 µM 0.912464927205719 0.176135323516647 no 642 0.180762012145936 928 5393175
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.911110707423505 0.176500222041831 no 643 0.181118522649701 931 23847180
SGTC_672 1441-0018 53.7 µM 0.910134343252556 0.176763602680094 no 644 0.181375832347955 847 251141
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.906380519803418 0.177778533518835 no 645 0.18236723996534 886 364106
SGTC_1333 1482-0047 286 µM 0.904500810893109 0.178288133755235 no 646 0.182864952290568 956 3811116
SGTC_2174 5790901 200 µM 0.90393807032784 0.178440874928454 no 647 0.183014120378978 874 786020
SGTC_685 1278-0033 54.9 µM 0.903034294980444 0.178686353502483 no 648 0.183253846866805 931 3590572
SGTC_1797 st048695 56.8 µM 0.902113817861738 0.178936586972577 no 649 0.183498204689985 907 592262 YIL048W NEO1
SGTC_987 1497-1013 404 µM 0.902030926943328 0.178959131846443 no 650 0.183520219594273 916 1676435
SGTC_365 0121-0052 13.6 µM 0.901836734371669 0.179011955813798 no 651 0.183571801422958 940 3101739
SGTC_102 gallobenzophenone 83.616 µM 0.901024506966983 0.17923300299261 no 652 0.183787644842588 910 70837
SGTC_77 0828-0286 12.516 µM 0.899826577652657 0.179559331856273 no 653 0.184106274076515 933 745345
SGTC_1213 1315-0166 115 µM 0.899442679032255 0.179663988940575 no 654 0.184208457425808 786 768401
SGTC_619 1652-1634 108 µM 0.898259538329991 0.179986773607606 no 655 0.184523599192803 851 5400454
SGTC_1211 1056-0033 32.3 µM 0.897686992132069 0.180143106433542 no 656 0.184676223119307 947 6741922
SGTC_2853 9015042 58.44 µM 0.896101591479414 0.180576442177032 no 657 0.185099253582325 872 6457456
SGTC_1978 st071761 42 µM 0.895609270897642 0.180711140513374 no 658 0.185230741252103 872 5147680
SGTC_1353 1498-1206 8.11 µM 0.893766517604411 0.1812158746499 no 659 0.185723413583907 943 6756808
SGTC_968 1309-0633 340 µM 0.893535779740439 0.181279136394642 no 660 0.185785160100147 922 3761976
SGTC_1194 1488-0194 225 µM 0.891008328701731 0.181972996608801 no 661 0.186462351047521 928 1391452
SGTC_3156 9099931 49.47 µM 0.889926537729728 0.182270487142635 no 662 0.186752666641379 968 18111053
SGTC_2205 7238770 200 µM 0.889417116312201 0.182410682296285 no 663 0.186889474724546 942 279867
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.885299788359551 0.183546261463575 no 664 0.187997482053563 925 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.885222528461111 0.183567612148362 no 665 0.188018312024295 865 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2524 avocatin b 10.57 µM 0.88477949644268 0.183690073424397 no 666 0.188137784989454 895 6710748
SGTC_3310 9130229 44.1445 µM 0.883940411586228 0.183922149620319 no 667 0.188364190353224 913 7761258
SGTC_800 3448-7362 155 µM 0.883386909179206 0.184075338610332 no 668 0.188513630630891 1099 15991913
SGTC_3286 9117135 37.221 µM 0.882883609524016 0.184214702265286 no 669 0.188649580097822 889 3438150
SGTC_675 1309-0189 238 µM 0.882034649270829 0.184449928081263 no 670 0.1888790350611 885 4246530
SGTC_2020 4017018 200 µM 0.881661490269725 0.184553380263905 no 671 0.188979945972441 921 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_194 1486-1323 56.904 µM 0.881040423662544 0.184725640733592 no 672 0.189147970512859 929 5178754
SGTC_1800 st050079 29.0735 µM 0.878795865915354 0.185349029473356 no 673 0.189755984103561 993 3645560
SGTC_2732 terfenadine 20 µM 0.875646511724563 0.186225909454666 no 674 0.19061111585857 933 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_277 nystatin 15.5 µM 0.873386655855177 0.186856706379641 no 675 0.191226180951707 999 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2987 9018338 71.43 µM 0.873091802152137 0.186939106739283 no 676 0.191306520933462 948 5055682
SGTC_1842 st055362 61.2 µM 0.868624748706471 0.188190226874666 no 677 0.192526206636172 995 676032
SGTC_648 0375-0473 33.3 µM 0.867872048601227 0.18840154860152 no 678 0.192732191090593 968 1713139
SGTC_1976 st070609 63.5 µM 0.866134406870305 0.188889952896164 no 679 0.193208229376212 956 682556
SGTC_1107 amlodipine 47 µM 0.864121615637737 0.189456668506038 no 680 0.193760542918859 903 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_209 4077-0173 175.592 µM 0.862385190341785 0.189946411090504 no 681 0.194237793684682 859 15993494
SGTC_659 k018-0002 107 µM 0.862069845420921 0.190035434617409 no 682 0.194324541943388 980 6797879 YHR007C ERG11
SGTC_3056 9094900 49.47 µM 0.857327736876399 0.191377247300941 no 683 0.195631891820964 958 25236784
SGTC_900 1112-0045 141 µM 0.855523171243081 0.191889383146826 no 684 0.196130791158439 862 56211 YIL048W NEO1
SGTC_3276 9139060 49.47 µM 0.855412984999422 0.191920681163265 no 685 0.196161278778713 956 4870619
SGTC_1961 st076550 68.7 µM 0.854588511635572 0.192154969084501 no 686 0.196389494917038 905 1579337
SGTC_1757 st041620 31.8375 µM 0.854395492352154 0.192209844015014 no 687 0.196442946340761 962 5289815
SGTC_1363 1636-0063 10.4 µM 0.854123416331238 0.192287210868845 no 688 0.19651830534179 991 6072185
SGTC_2475 5812728 15.03 µM 0.854042954248424 0.192310094513301 no 689 0.196540594903309 1047 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2401 5128683 200 µM 0.852874199418322 0.192642679476035 no 690 0.196864535415133 924 708373
SGTC_796 1234-0020 70.7 µM 0.852497967598446 0.192749816064979 no 691 0.19696888328107 968 46495034
SGTC_782 0083-0095 30.5 µM 0.850460741142865 0.193330573114002 no 692 0.197534489129616 1022 3591729 An indicator and reagent.
SGTC_890 0929-0006 47.2 µM 0.850200342826835 0.19340488237646 no 693 0.197606855586849 936 1378169
SGTC_3139 9095020 49.47 µM 0.849721670724339 0.193541525373209 no 694 0.197739923606667 806 25236292
SGTC_1021 4476-0760 85.3 µM 0.849384548927885 0.193637796377128 no 695 0.19783367396632 947 746768
SGTC_3161 9100388 49.47 µM 0.847325023140221 0.194226563750833 no 696 0.198406991389727 1016 25236368
SGTC_1457 k015-0032 57.3 µM 0.847158278803569 0.19427427948435 no 697 0.198453452423598 955 4302660
SGTC_2829 7992743 58.44 µM 0.846224393192899 0.19454165309052 no 698 0.198713788215615 999 16462845
SGTC_3005 9076496 71.4286 µM 0.845313799909265 0.194802573574874 no 699 0.198967829075999 953 21368410
SGTC_2226 7298446 200 µM 0.845312666262519 0.194802898541478 no 700 0.198968145467115 964 3283010
SGTC_1777 st045864 34.765 µM 0.845083949826471 0.19486846821641 no 701 0.199031984470504 991 4691462
SGTC_145 3737-0113 38.366 µM 0.844958689261049 0.194904384285988 no 702 0.199066952249678 1084 6849351
SGTC_2268 7933382 153.85 µM 0.844628902770766 0.1949989634987 no 703 0.199159033250419 1086 935025 YOR257W CDC31
SGTC_141 0443-0274 32.331 µM 0.843706066601385 0.195263771222116 no 704 0.199416838333197 1123 1627241
SGTC_863 0466-0191 129 µM 0.842029768624201 0.195745343315004 no 705 0.199885645406167 1021 765160 YPR165W RHO1
SGTC_2695 st077686 51.995 µM 0.838665677307167 0.196713962492032 no 706 0.200828471970437 967 2876092
SGTC_1274 0865-0114 173 µM 0.837570503751169 0.197029919943677 no 707 0.201135982279904 982 870624
SGTC_1189 1431-2119 7.28 µM 0.837026409883315 0.197187005104679 no 708 0.201288861606233 1016 3107275
SGTC_1651 st011928 86.1 µM 0.836379192822977 0.197373961573811 no 709 0.201470807143824 970 720198
SGTC_2658 polymyxin b sulfate 77.05 µM 0.834210504169175 0.198001194501351 no 710 0.202081186477549 988 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3123 9126162 49.47 µM 0.834107612676819 0.198030982887685 no 711 0.202110172848722 1015 25239884
SGTC_2471 5466956 24.79 µM 0.833833722248285 0.198110290815084 no 712 0.202187344799513 973 724419
SGTC_1591 genipin 88.4 µM 0.832608324488532 0.198465352726029 no 713 0.202532831304436 951 442424 A DNA cross-linking agent.
SGTC_1181 1222-0449 220 µM 0.831719176552086 0.198723225644731 no 714 0.202783736919346 992 658318
SGTC_1390 3413-2614 145 µM 0.831314342786907 0.1988407034537 no 715 0.202898037074746 1049 3421432
SGTC_1401 3807-4679 7.6 µM 0.83116675310025 0.198883542587378 no 716 0.202939716894727 966 3291456
SGTC_288 1315-0019 35.1 µM 0.830943535757571 0.198948343845325 no 717 0.203002763931754 1010 6811474
SGTC_3341 9147222 25.867 µM 0.830371033014507 0.199114602791242 no 718 0.203164518993625 952 1939759
SGTC_2178 5812956 200 µM 0.830008963878025 0.199219793486987 no 719 0.20326685779864 1025 5403383
SGTC_2504 purpurogallin 52.29 µM 0.826683063369889 0.200187620824633 no 720 0.20420836171608 951 5281571 An antioxidant.
SGTC_1913 st060213 96.1 µM 0.82583153924648 0.200435865459417 no 721 0.204449830142097 1043 688959
SGTC_2985 9022375 71.43 µM 0.825481744832898 0.200537894500875 no 722 0.20454907127872 1031 4939335
SGTC_2420 aureobasidin a 50 nM 0.823464999330306 0.201126752665924 no 723 0.205121806544539 1024 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2269 7935389 174.42 µM 0.822596369391913 0.201380698203993 no 724 0.205368781982411 964 97605
SGTC_2767 sibutramine 71.45 µM 0.822563244527927 0.201390386120611 no 725 0.205378203789217 1009 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2266 7929956 200 µM 0.819496496386768 0.202288517140137 no 726 0.206251600047338 1042 2967153
SGTC_1519 esterone 74 µM 0.816540443443727 0.203156493428284 no 727 0.207095551042282 996 698 A steroid.
SGTC_889 0919-1524 82.7 µM 0.816264646254007 0.203237588101156 no 728 0.207174395000275 968 3905452
SGTC_637 1181-0519 7.26 µM 0.814895790826869 0.203640368544402 no 729 0.207565981372265 1084 6252091 YGR060W ERG25
SGTC_1109 tnp00067 928.257 nM 0.814268965037715 0.203824968397801 no 730 0.207745442367909 987 676295
SGTC_1253 0550-0034 176 µM 0.813288533086302 0.204113905004867 no 731 0.208026324962268 969 5969915
SGTC_1803 st050068 52.4 µM 0.813085571753726 0.204173748861097 no 732 0.208084499069108 1110 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_664 1222-0054 14.9 µM 0.81271206805029 0.204283905035387 no 733 0.20819158023848 1033 6813991
SGTC_998 3996-0085 177 µM 0.810434235976434 0.204956463893119 no 734 0.208845323904912 1088 715391
SGTC_2666 tannic acid 100 µM 0.809518012108837 0.205227361443726 no 735 0.209108623235936 1053 16134267 A thiamine antagonist.
SGTC_1230 0170-0365 3.77 µM 0.809214683295004 0.205317092743919 no 736 0.209195835235782 1134 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_121 0557-0495 61.343 µM 0.807757772975205 0.205748403372877 no 737 0.20961501912441 1202 3104427
SGTC_446 go6976 132 µM 0.80731651502942 0.205879141473854 no 738 0.209742075762979 1024 3501 A protein kinase C inhibitor.
SGTC_535 2293-4129 48.2 µM 0.805652260695062 0.206372678317547 no 739 0.210221691553702 1082 396118 YIL048W NEO1
SGTC_283 0987-0079 11.7 µM 0.805630428778524 0.206379157256836 no 740 0.210227987496584 1075 411556
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.804606837780193 0.206683058076984 no 741 0.210523297526909 1006 803109
SGTC_449 xestospongin c 11.1929 µM 0.804507368080883 0.206712604425517 no 742 0.210552007899418 1025 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_663 1486-0733 13.9 µM 0.804435995075962 0.206733806509932 no 743 0.210572610016449 1025 722445 YPR165W RHO1
SGTC_492 tmb-8 126 µM 0.802995222472885 0.207162078085973 no 744 0.210988747970201 908 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1737 st035557 69.7 µM 0.802444821399826 0.207325823969555 no 745 0.21114784734118 901 5716916
SGTC_276 colchicine 750 µM 0.80209265438119 0.207430634794153 no 746 0.211249681892339 1055 2833 A microtubule depolymerizer.
SGTC_56 0957-0365 83.25 µM 0.799816562222708 0.208108793107879 no 747 0.211908542857009 1024 6752360
SGTC_755 1995-0008 37.3 µM 0.798381558771114 0.20853702202422 no 748 0.212324550783865 1085 689533
SGTC_1038 k292-0204 154 µM 0.795834481449862 0.209298390520564 no 749 0.213064123495459 990 4454212
SGTC_1102 cgs 12066b 26.1 µM 0.791793564520774 0.210509646288901 no 750 0.21424052768907 1007 6438352 A 5-HT1B full agonist.
SGTC_3133 9127736 49.47 µM 0.791745386274518 0.2105241123835 no 751 0.214254576245037 1052 27243420
SGTC_1158 4092-0494 91.8 µM 0.791620102515759 0.210561733061399 no 752 0.214291110923972 1094 1148199
SGTC_337 1315-0038 354 µM 0.790341552355314 0.210945886421138 no 753 0.214664163041216 1016 1626437
SGTC_2747 doxorubicin 7.63 µM 0.788973799763562 0.211357296125601 no 754 0.215063659956053 912 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2440 5628896 157.78 µM 0.788570033138367 0.211478835882819 no 755 0.215181675689135 1037 5522048
SGTC_2441 5730946 39.09 µM 0.788235006593586 0.21157971491449 no 756 0.215279628120364 1047 1774275
SGTC_3187 9109394 49.47 µM 0.787885246769052 0.211685060299447 no 757 0.215381915754431 1052 17098090
SGTC_147 4466-0538 29.23 µM 0.787327309907421 0.211853170784131 no 758 0.215545143337445 1178 6742687 YHR072W ERG7
SGTC_1640 st009078 66.4 µM 0.785074668256454 0.212532702125555 no 759 0.216204895505828 1006 690618
SGTC_1207 2099-0101 141 µM 0.784415324444551 0.212731840225254 no 760 0.216398224664439 1111 5837381
SGTC_184 1494-0393 24.714 µM 0.782739594931211 0.213238441877133 no 761 0.216890022871329 1067 3090647
SGTC_316 k060-0003 58.6 µM 0.782169032472143 0.213411093071149 no 762 0.21705762061571 1053 6152314
SGTC_2403 6032726 181.2 µM 0.780761417595043 0.21383738317042 no 763 0.217471415110092 1048 2881040
SGTC_2534 helenine 20.12 µM 0.780413521798586 0.213942818282309 no 764 0.217573755669074 1046 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2375 9072683 200 µM 0.780255115509649 0.213990835742867 no 765 0.217620363278651 1149 16798029
SGTC_857 0438-0306 1.35 µM 0.779232135954789 0.214301081036009 no 766 0.217921491503147 1066 4686136
SGTC_2385 9074692 200 µM 0.778212491677443 0.214610575017066 no 767 0.218221876906042 1057 17046906
SGTC_530 4358-1714 28 µM 0.777063095318559 0.214959764118109 no 768 0.218560772932704 1080 1564641
SGTC_1224 0823-0416 294 µM 0.775655103824213 0.215387964325441 no 769 0.218976327611819 1084 3598164
SGTC_219 mitoxanthrone 164.414 µM 0.775115203819578 0.215552290589025 no 770 0.219135794186858 1041 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2243 6634756 200 µM 0.772077886818484 0.216478095361907 no 771 0.220034149214831 1045 885676
SGTC_1709 st033179 39.1045 µM 0.771977113344342 0.216508851516169 no 772 0.220063991411986 1092 573381
SGTC_655 k060-0012 42 µM 0.771802279038146 0.216562217100409 no 773 0.220115770860226 1068 5994525
SGTC_1862 st057513 3.81 µM 0.770918767824337 0.216832012190324 no 774 0.220377541031322 1101 5393163
SGTC_2698 st077697 67.5 µM 0.77057514846186 0.216936994637469 no 775 0.220479398102575 1027 3154499
SGTC_605 1315-0399 119 µM 0.770401350887 0.216990104387436 no 776 0.220530926169804 1111 24020461
SGTC_3201 9113999 49.47 µM 0.769623697410323 0.217227834827205 no 777 0.220761571885541 1036 16649224
SGTC_2008 4012253 172 µM 0.768960489392461 0.217430697836678 no 778 0.220958383104566 1079 603940
SGTC_3302 9125395 16.351 µM 0.768285214526164 0.217637364203357 no 779 0.221158878389927 1050 17599668
SGTC_2571 chrysanthemic acid 100 µM 0.767501964075513 0.217877218184311 no 780 0.221391562941241 1033 2743 An insecticide.
SGTC_707 0865-0008 204 µM 0.767385968804797 0.217912752252334 no 781 0.221426034195483 1117 723043
SGTC_966 1300-0360 30.2 µM 0.767165459588167 0.217980312406108 no 782 0.22149157316682 1055 70588
SGTC_1897 st060201 15 µM 0.765730710113305 0.218420189282418 no 783 0.221918275060862 1044 611878
SGTC_495 decylubiquinone 155 µM 0.765191994325599 0.21858548496979 no 784 0.22207861305608 1069 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_826 1683-5028 118 µM 0.76469828373035 0.21873703481171 no 785 0.222225614209871 1064 722377
SGTC_2921 7974240 10.71 µM 0.764636225723249 0.218756088469823 no 786 0.222244095761172 1075 2979074 YDR527W RBA50
SGTC_1079 idarubicin 2.36 µM 0.763284044242683 0.219171485566244 no 787 0.222647007839384 1059 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2713 st079149 53.4 µM 0.762854265485488 0.219303610721058 no 788 0.222775156980954 1084 3103253
SGTC_1772 st048439 82.2 µM 0.760365050224147 0.220069759957754 no 789 0.223518204134632 1077 2927068 YDL195W SEC31
SGTC_2532 xanthone 78.9 µM 0.758025322054789 0.220791296774846 no 790 0.22421791187878 1002 7020 An insecticide.
SGTC_1696 st025591 34.7925 µM 0.754736021352384 0.221807954750367 no 791 0.225203694319935 1132 2787147
SGTC_3160 9100216 49.47 µM 0.754384839803311 0.221916655803496 no 792 0.22530908603902 1087 17191039
SGTC_3289 9119912 71.43 µM 0.753357444903512 0.22223483946781 no 793 0.225617573825335 1117 17014829
SGTC_544 k015-0020 52.4 µM 0.751133872763336 0.222924369242068 no 794 0.226286046062471 1094 3008304
SGTC_2619 obliquin 87.91 µM 0.749783400513834 0.223343744883691 no 795 0.226692583887702 1113 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1665 st014639 11.4 µM 0.747357322470987 0.224098265721915 no 796 0.227423949745683 1186 981133 YIL048W NEO1
SGTC_1092 toremifene 6.32 µM 0.747046550296055 0.224195021721289 no 797 0.22751773111223 1148 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_867 0518-0118 155 µM 0.746745406361457 0.224288802685616 no 798 0.227608627749102 1159 6848158
SGTC_908 3448-7491 47.7 µM 0.746715691888175 0.224298057447644 no 799 0.227617597809894 1150 1203031
SGTC_3140 9094243 49.47 µM 0.746257701285968 0.224440728958145 no 800 0.227755878960178 1183 19291112
SGTC_1491 4138-0063 26.5 µM 0.746145749017927 0.224475611739501 no 801 0.227789687910218 1092 23883227
SGTC_1850 st056238 17 µM 0.746038509273303 0.224509029048413 no 802 0.22782207635336 1163 5393177
SGTC_1637 st007924 17.4 µM 0.745373905953118 0.224716191090753 no 803 0.228022856986821 1113 683336
SGTC_2329 6138490 200 µM 0.745281873513887 0.224744886863489 no 804 0.228050668379637 1002 720019
SGTC_297 0986-0032 24 µM 0.744383468337815 0.225025119295646 no 805 0.228322258701925 1097 2847425
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.743878172067129 0.225182819335069 no 806 0.228475090973392 1157 16486 A toxic proline analog.
SGTC_1876 myriocin 605 nM 0.743761107769437 0.225219363354405 no 807 0.228510506522886 1135 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_487 nimodipine 119 µM 0.742032263047108 0.225759448638475 no 808 0.229033894145752 1045 4497 L-type voltage-gated calcium channels inhibitor
SGTC_368 fentichlor 4.58 µM 0.740148252681552 0.22634884043966 no 809 0.22960502135721 1086 7329 A pesticide.
SGTC_3215 9129942 49.47 µM 0.737443139842717 0.227196622911472 no 810 0.230426454617771 1076 17682944
SGTC_1068 loratadine 26.9 µM 0.737065331775067 0.227315170243691 no 811 0.230541310238663 1103 3957 A H1 histamine antagonist.
SGTC_2814 7977482 42.97 µM 0.736562398833367 0.227473032898965 no 812 0.230694254105467 1162 6456762
SGTC_814 3342-0569 96 µM 0.736185563294955 0.227591356038423 no 813 0.23080888839828 1153 4346283
SGTC_1556 plumbagin 1.48 µM 0.733877894103898 0.228316699887741 no 814 0.231511580507998 1070 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3338 9144300 39.5675 µM 0.732959369071294 0.228605770682904 no 815 0.231791605586165 1119 4901274
SGTC_298 1391-0729 10 µM 0.731998782081956 0.228908298638792 no 816 0.232084655572335 1116 3237558
SGTC_1185 1319-0113 81.3 µM 0.731865544606284 0.228950278280867 no 817 0.232125319125354 1125 4672763
SGTC_3277 9138724 49.47 µM 0.729321578924913 0.229752643504269 no 818 0.232902487712858 1027 15943418
SGTC_1284 0929-0043 16 µM 0.728625456401413 0.229972474204621 no 819 0.233115401205836 1113 1239883
SGTC_985 1493-0307 8.71 µM 0.727900051406939 0.230201677308506 no 820 0.233337385858889 1128 3278274
SGTC_2776 terbinafine 19.92 µM 0.727775679797147 0.230240987300315 no 821 0.233375457185802 1169 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.72668469812414 0.230585973491513 no 822 0.233709564672248 1205 368090
SGTC_1302 1159-0335 255 µM 0.724884884326991 0.231155734784943 no 823 0.234261327400551 1140 649284
SGTC_1261 0712-0010 12.7 µM 0.723319437975928 0.231651941250022 no 824 0.234741826675275 1163 2840123
SGTC_2040 5100729 123 µM 0.722562559761942 0.231892065010391 no 825 0.234974338706796 1154 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1409 3909-8004 61.9 µM 0.721223219245013 0.23231731762678 no 826 0.235386094063797 1166 2119279
SGTC_500 h-89 112 µM 0.717750176132626 0.23342205852626 no 827 0.236455669581757 1186 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2171 5739187 198.077 µM 0.716863003168997 0.233704726129987 no 828 0.23672931605806 1126 2262761
SGTC_805 3852-0218 479 µM 0.716643181038252 0.233774794325797 no 829 0.236797146608575 1130 6615355
SGTC_3154 9100113 49.47 µM 0.715286276485906 0.234207564642371 no 830 0.237216083379196 1159 25237525
SGTC_608 k048-0125 159 µM 0.713571288141055 0.234755175978942 no 831 0.237746158496819 1190 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1684 st024538 14.6195 µM 0.713228028963118 0.234864866705383 no 832 0.237852332332554 1167 6732859
SGTC_2005 4024620 188 µM 0.71266291901832 0.235045512992425 no 833 0.238027183674897 1181 236743
SGTC_2709 st078560 56 µM 0.710331514401457 0.235791594107837 no 834 0.238749290738223 1184 17250903
SGTC_2121 5257820 149.641 µM 0.709726643956287 0.235985373968442 no 835 0.238936833167161 1218 791256
SGTC_853 0419-0306 21 µM 0.708494053233994 0.236380525491112 no 836 0.23931925191381 1131 762713
SGTC_911 3456-4043 236 µM 0.70809385091883 0.236508903103649 no 837 0.239443488973147 1212 914281
SGTC_2837 9008476 45.46 µM 0.706822888781377 0.236916858909646 no 838 0.239838274339862 1203 2992805
SGTC_2903 5923464 63.88 µM 0.706502161889024 0.237019867521045 no 839 0.239937954380293 1217 2876576
SGTC_354 2783-3500 4.88 µM 0.706242611403233 0.237103245978212 no 840 0.240018637689203 1160 6740761
SGTC_501 nsc-95397 161 µM 0.706207181501996 0.237114628792354 no 841 0.240029652499919 1181 262093
SGTC_3110 9122132 49.47 µM 0.704493787080452 0.237665461311582 no 842 0.240562658923708 1235 918317
SGTC_2688 kanamycin b 96.69 µM 0.703570097404538 0.237962705732677 no 843 0.240850269421824 1328 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1455 4262-0120 131 µM 0.701320710071298 0.238687412944351 no 844 0.241551445999412 1234 1529587
SGTC_144 4161-2749 112.381 µM 0.699572629682084 0.239251442066151 no 845 0.242097120244883 1109 797501 YMR168C CEP3
SGTC_547 1120-0019 610 nM 0.697054883906847 0.240065086678852 no 846 0.242884223567547 1144 3676939
SGTC_1892 st058411 7.36 µM 0.696740806793141 0.240166690795974 no 847 0.242982508103707 1173 3934738
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.696595422106454 0.2402137307557 no 848 0.243028010795137 1062 88881 An O-methylated flavonoid and antioxidant.
SGTC_2528 xanthyletin 44.79 µM 0.695596498625372 0.24053707329067 no 849 0.243340779774384 1235 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_844 0330-0132 15.3 µM 0.694334607815666 0.240945874532045 no 850 0.243736196175681 1203 2828079
SGTC_1354 1498-1681 81 µM 0.692560155968646 0.241521363406839 no 851 0.244292811064654 1234 5754243
SGTC_2964 9083345 53.42 µM 0.691950587117109 0.241719230436067 no 852 0.244484180277857 1179 17741579
SGTC_1521 st012942 49.4 µM 0.691240645526626 0.241949789484811 no 853 0.244707162468863 1241 24207259
SGTC_2723 salbutamol 83.58 µM 0.689358336133445 0.242561661099347 no 854 0.245298897764167 1179 9884233 β2-adrenoceptor agonist
SGTC_3343 9148379 18.9835 µM 0.689350003985679 0.242564371444898 no 855 0.245301518822392 1238 1955036
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.6883908752759 0.242876473837762 no 856 0.245603334195688 1195 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2997 9067075 71.4286 µM 0.687763001499933 0.243080902837067 no 857 0.24580101935767 1199 27209819
SGTC_2345 9052315 157.45 µM 0.687323037215578 0.243224205940504 no 858 0.245939592364588 1205 6469265
SGTC_432 NS 1619 61.3 µM 0.686897927100949 0.243362714184601 no 859 0.24607352665158 1208 4552 A K+/calcium channel activator.
SGTC_583 1488-1091 88.9 µM 0.685438121770018 0.243838668384825 no 860 0.246533747514835 1304 4303273
SGTC_2193 5925765 200 µM 0.682664282215785 0.244744432124675 no 861 0.247409502218264 1218 877370
SGTC_443 clozapine 122 µM 0.681611974938085 0.24508852366743 no 862 0.247742170442137 1148 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1731 st035964 63 µM 0.681377821623573 0.245165124297844 no 863 0.247816226319548 1192 6739575
SGTC_1554 st069299 38.7 µM 0.679131685899028 0.245900576042495 no 864 0.248527213679481 1215 24207999
SGTC_1547 harmine 94.2 µM 0.679073307199058 0.245919706741799 no 865 0.248545707237626 1260 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_50 0929-0078 56.389 µM 0.676727715732633 0.246689017351728 no 866 0.249289364057453 1137 1377751
SGTC_922 1866-0035 480 µM 0.675830485098308 0.246983632819715 no 867 0.249574138570319 1220 3156169
SGTC_1920 st075728 45.7 µM 0.675195920160598 0.247192112748496 no 868 0.249775649181475 1243 3400306
SGTC_357 1325-0123 420 µM 0.674751395642651 0.247338212842781 no 869 0.249916862543827 1210 1098503
SGTC_2485 5633444 17.78 µM 0.673198257338489 0.247849038772289 no 870 0.250410584863824 1214 5724239
SGTC_2627 acetyl isogambogic acid 100 µM 0.671953260563883 0.248258923500305 no 871 0.250806726008571 1199 6857789 A caspase activator and apoptosis inducer.
SGTC_2563 tomatine 8.54 µM 0.671892422026811 0.248278962358559 no 872 0.250826092507926 1236 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_496 calpeptin 138 µM 0.670920286371391 0.248599279131909 no 873 0.251135656105792 1198 73364 A calpain inhibitor.
SGTC_1720 st037298 9.481 µM 0.669275438639727 0.24914175416322 no 874 0.251659895755528 1234 597396
SGTC_1456 k015-0012 13 µM 0.669032088709595 0.249222065032281 no 875 0.251737504377964 1302 2989616
SGTC_149 3970-0822 46.1 µM 0.668240463893659 0.249483413967502 no 876 0.251990055017112 1289 3114250 YBL034C STU1
SGTC_2092 5303694 80.6725 µM 0.663926569376384 0.250910169040255 no 877 0.253368655037498 1240 1963699
SGTC_2815 7968870 71.43 µM 0.662725051146703 0.251308320482406 no 878 0.253753331296689 1251 2977326 YHR190W ERG9
SGTC_1909 st060837 51.5 µM 0.662400207888003 0.251416022301437 no 879 0.253857385258733 1211 678937
SGTC_2349 9023730 187.07 µM 0.661587443054964 0.251685601415887 no 880 0.254117828602787 1251 4126287
SGTC_609 0986-0026 86.3 µM 0.659755278080602 0.252293856262693 no 881 0.254705443418149 1242 2848610
SGTC_871 0574-0004 149 µM 0.658812845044089 0.252607033316772 no 882 0.255007978903327 1238 9551173
SGTC_2782 7736369 71.43 µM 0.658206401648557 0.252808666907222 no 883 0.255202755918129 1292 2950836 YOL077C BRX1
SGTC_2133 5320837 200 µM 0.658001105183389 0.252876944181976 no 884 0.255268710496371 1249 2841355
SGTC_1802 st050112 57.9 µM 0.657350403598068 0.253093417926757 no 885 0.255477817040096 1248 4662563
SGTC_3255 9139072 49.47 µM 0.657180003857129 0.253150122180135 no 886 0.255532590720072 1267 17646060
SGTC_2760 etidronate 98.04 µM 0.656386683285526 0.253414204954695 no 887 0.255787678230221 1251 3305 A chelator and antioxidant.
SGTC_3260 9137109 49.47 µM 0.656067015610682 0.253520657736361 no 888 0.25589050302985 1141 17478346
SGTC_886 0866-0150 153 µM 0.655612260753948 0.253672136482133 no 889 0.256036817343913 1278 271463
SGTC_1186 1319-0216 26 µM 0.655452794058103 0.253725266058895 no 890 0.256088135012814 1314 4565136
SGTC_1018 4259-0013 28.1 µM 0.655022524091935 0.253868648406177 no 891 0.256226626118881 1268 6801262
SGTC_2363 9053361 176 µM 0.65352032787679 0.254369570669575 no 892 0.256710444370639 1311 6469797 YMR079W SEC14
SGTC_58 0957-0393 9 µM 0.652992145619432 0.254545821313843 no 893 0.256880671059598 1215 6997992
SGTC_458 nppb 133 µM 0.652625154794057 0.254668321188108 no 894 0.25699898229561 1308 4549 A chloride channel blocker.
SGTC_1146 3579-1023 7 µM 0.652151382920055 0.254826509735078 no 895 0.257151759726484 1311 X1146
SGTC_617 3770-0098 35 µM 0.650463701641282 0.255390430360505 no 896 0.257696370565407 1244 5962639
SGTC_1875 nocodazole 6 µM 0.650145357666932 0.255496874655932 no 897 0.257799166515087 1254 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_42 0133-0086 60.653 µM 0.6477619409797 0.256294550647205 no 898 0.25856946742482 1223 162923 Model of phenazepam hydroxylation.
SGTC_677 0929-0063 136 µM 0.6462333499341 0.256806818122023 no 899 0.259064122221311 1239 1539583
SGTC_3164 9100705 49.47 µM 0.646019766075016 0.256878437599765 no 900 0.25913327728198 1290 17174235
SGTC_1182 1222-0449 220 µM 0.644993059827888 0.257222860341329 no 901 0.25946584161214 1278 658318
SGTC_190 3970-0790 3.722 µM 0.644654286126809 0.257336559296139 no 902 0.259575623440244 1264 2832352
SGTC_1522 st012842 45.6 µM 0.644260077951225 0.257468895996037 no 903 0.259703399355474 1210 3491067 YOR116C RPO31
SGTC_468 gf-109203x 121 µM 0.642539783018475 0.258046816947524 no 904 0.260261383577976 1211 2396 A protein kinase C inhibitor.
SGTC_2789 5281112 71.43 µM 0.642364414755242 0.258105768443301 no 905 0.260318299620314 1267 765948
SGTC_1420 4'-methoxyflavone 42 µM 0.642227255081155 0.258151880671488 no 906 0.260362819474359 1279 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3086 9117350 49.47 µM 0.641325762047849 0.258455063274212 no 907 0.260655527384517 1207 2679265
SGTC_450 aminopyrene 156 nM 0.64128428138623 0.258469018141118 no 908 0.260668999913672 1272 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1785 bathophenanthroline 24 µM 0.640783395168852 0.258637556396197 no 909 0.260831711338831 1257 72812 An iron chelator.
SGTC_2871 9038510 12.99 µM 0.639549556914102 0.259052961015452 no 910 0.261232742844816 1300 4945164
SGTC_842 0271-0008 11.1 µM 0.63934134691042 0.259123094484431 no 911 0.261300448074591 1335 1221709
SGTC_491 tetrandrine 80.3 µM 0.639336416899074 0.259124755228684 no 912 0.261302051313103 1307 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2183 6420625 130.508 µM 0.639022734467968 0.259230434918075 no 913 0.261404071153454 1275 2897619
SGTC_909 3448-9333 149 µM 0.635538383287869 0.260405809891226 no 914 0.262538670696184 1264 3344074
SGTC_3085 9117376 49.47 µM 0.635478150693213 0.260426152240211 no 915 0.262558306207588 1338 16480349
SGTC_1612 st002233 45.4 µM 0.632393675477918 0.261468964802517 no 916 0.26356483280675 1294 1035021
SGTC_281 1672-3440 14.9 µM 0.630838641209051 0.261995509186025 no 917 0.264073017414538 1293 6833000
SGTC_400 oxethazaine 37.5 µM 0.629556933633168 0.262429911744968 no 918 0.264492253961323 1275 4621 A local anesthetic.
SGTC_123 0083-0120 66.675 µM 0.628676252094082 0.262728610217368 no 919 0.264780514202556 1246 16001701
SGTC_606 k015-0008 38.6 µM 0.628524873886516 0.262779970281901 no 920 0.264830078636726 1363 1970475
SGTC_172 1112-0046 2.638 µM 0.628372920750358 0.262831530574069 no 921 0.264879836057636 1276 2802135 YIL048W NEO1
SGTC_133 0724-0033 378.92 µM 0.628264622325252 0.262868281235174 no 922 0.264915301537994 1193 280309
SGTC_1231 0242-0792 125 µM 0.627555750770126 0.263108898988402 no 923 0.265147501800461 1286 3707635
SGTC_568 1193-0097 7.48 µM 0.626955893106767 0.263312601188953 no 924 0.265344073829466 1210 3646150
SGTC_3108 9121785 49.47 µM 0.62451947161458 0.264140798543625 no 925 0.266143243385014 1278 17140271
SGTC_2407 paclitaxel 400 µM 0.624261565178403 0.264228544650758 no 926 0.266227910440783 1440 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2722 naftopidil 47.16 µM 0.623375309438291 0.264530183740418 no 927 0.266518959627708 1303 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.620894570353437 0.265375439313611 no 928 0.267334496944773 1331 66535 A nucleotide analog.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.620254692304187 0.265593685413174 no 929 0.267545059467675 1278 75037 A free radical scavenger.
SGTC_3254 9136651 49.47 µM 0.620152475628695 0.265628557347427 no 930 0.267578703310201 1284 16454030
SGTC_41 0478-0632 82.643 µM 0.619701374018502 0.265782481548992 no 931 0.267727205451759 1300 3750424
SGTC_3037 9091026 49.47 µM 0.61922438752087 0.26594528731602 no 932 0.267884274030032 1327 25236398 YIL048W NEO1
SGTC_923 1900-2434 73.3 µM 0.618885183594549 0.26606109565711 no 933 0.267995999927673 1285 5910570
SGTC_459 nigericin 15.3 µM 0.616424290496884 0.266902038551052 no 934 0.268807262880585 1359 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_182 3448-4371 550.524 µM 0.615965075091265 0.267059111383863 no 935 0.268958785196074 1359 3491403
SGTC_3009 9080819 71.4286 µM 0.615442100173493 0.267238049736913 no 936 0.269131397750022 1296 17027216
SGTC_1957 st077035 62.4 µM 0.614219435841728 0.267656626099605 no 937 0.269535165819006 1392 705593
SGTC_1839 st053978 48 µM 0.612821734683635 0.268135530376689 no 938 0.269997108953421 1363 3788398
SGTC_520 3584-0023 682 µM 0.611744776877513 0.268504830016094 no 939 0.270353315782637 1295 1340790
SGTC_1806 st050005 60.3 µM 0.610522378659135 0.26892431223177 no 940 0.270757911873835 1284 5194765
SGTC_3023 9089636 49.47 µM 0.609447221405844 0.269293538525211 no 941 0.271114023030668 1387 17249241
SGTC_732 3970-1727 52.7 µM 0.608352543368061 0.26966972958661 no 942 0.271476839630361 1357 1275699
SGTC_3248 9135562 49.47 µM 0.607849421007228 0.2698427181185 no 943 0.271643673989789 1359 17650701
SGTC_2075 5212009 200 µM 0.605003746630396 0.270822190749126 no 944 0.272588253636717 1314 780898
SGTC_2045 5106652 78.05 µM 0.60447296337314 0.271005080939255 no 945 0.272764619565924 1318 673349
SGTC_3349 9149703 23.001 µM 0.604365242685628 0.271042205411452 no 946 0.272800419351029 1310 4910494
SGTC_2476 5806916 10.51 µM 0.602659766594181 0.271630312384822 no 947 0.273367525955716 1283 2870194
SGTC_847 0342-0274 5.54 µM 0.601540431315786 0.272016642822664 no 948 0.273740045481851 1346 18097
SGTC_392 N-ethylmaleimide 8.33 µM 0.600915032260818 0.27223261368231 no 949 0.273948290216638 1287 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3294 9122953 26.2835 µM 0.599827933096979 0.272608227458331 no 950 0.274310457635059 1314 16459826
SGTC_1254 0550-0035 264 µM 0.599092608469948 0.272862442101368 no 951 0.274555565214854 1382 15121435
SGTC_417 st075190 100 µM 0.599047433899494 0.272878063576828 no 952 0.274570626888522 1396 222757
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.59854670246145 0.273051247416775 no 953 0.274737603274521 1331 97141
SGTC_3261 9137475 49.47 µM 0.598094527111094 0.273207684363762 no 954 0.27488843091486 1269 17027690
SGTC_370 0180-0345 38.7 µM 0.597898119896991 0.273275648259883 no 955 0.274953957228127 1308 3989527
SGTC_2919 7978188 46.38 µM 0.597777402799104 0.273317424833217 no 956 0.274994235261635 1335 2980291
SGTC_2742 clothiapine 36.27 µM 0.597706791062448 0.273341862907307 no 957 0.275017796667571 1330 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_914 3820-6779 408 µM 0.597652591985825 0.273360621444414 no 958 0.27503588224569 1320 2893481
SGTC_1656 st012921 11 µM 0.597149606099374 0.273534737460399 no 959 0.275203750510608 1336 6732821
SGTC_3206 9114350 49.47 µM 0.594874128828954 0.274323112804153 no 960 0.27596380593176 1290 17087243
SGTC_957 1187-1561 14.1 µM 0.593920645947891 0.27465379533408 no 961 0.27628259472276 1320 1538454
SGTC_439 amiodarone 34.4 µM 0.593807326295072 0.274693109399917 no 962 0.276320494182635 1337 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_247 mechlorethamine 29.705 µM 0.593429367437749 0.27482425498868 no 963 0.276446919965429 1294 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_856 0433-0016 11.3 µM 0.592824285832681 0.275034272718557 no 964 0.276649376470563 1340 3911780
SGTC_770 0389-1121 67.2 µM 0.592299171135016 0.275216598794151 no 965 0.27682513542316 1442 6753108
SGTC_2830 7992007 71.43 µM 0.591333280478651 0.275552122842447 no 966 0.277148567411417 1359 1952075
SGTC_630 4356-0227 183 µM 0.587898235401893 0.276746991049392 no 967 0.278300300479202 1379 779312
SGTC_1630 st005209 31.3 µM 0.58760235924391 0.276850029136042 no 968 0.278399613554789 1369 3367314
SGTC_2834 9001755 58.44 µM 0.587325769270957 0.276946367848283 no 969 0.278492468692415 1372 2989575
SGTC_762 1165-0429 115 µM 0.586699911011972 0.277164420337352 no 970 0.278702633777423 1446 5967793
SGTC_785 1270-0111 65.3 µM 0.583792095285385 0.278178619809291 no 971 0.279680098558824 1338 6741994
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.581466866148695 0.278990922529225 no 972 0.280462921568118 1389 4213774
SGTC_931 2812-0076 566 µM 0.581303365129216 0.279048083865873 no 973 0.280518006508548 1373 3450959
SGTC_480 am 92016 50 µM 0.581237723296253 0.279071034406981 no 974 0.280540123296019 1294 2129 K+ channel blocker.
SGTC_2365 9042475 200 µM 0.580309306104811 0.279395737816235 no 975 0.280853026439471 1369 6464479
SGTC_2506 ethyl hematommate 54.16 µM 0.578317875910452 0.28009283636242 no 976 0.281524763905652 1318 3940691 An allergen.
SGTC_2168 5727979 200 µM 0.576804492673901 0.280623158045004 no 977 0.282035767140145 1300 695210
SGTC_366 0181-0206 4.31 µM 0.575842548473653 0.280960496096085 no 978 0.282360805591095 1442 274874
SGTC_591 4299-0174 154 µM 0.57510188109807 0.281220369465584 no 979 0.282611197907926 1383 5509088
SGTC_1692 fluoroquinolonic acid 71 µM 0.57406924905071 0.281582876268355 no 980 0.282960470735884 1392 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2576 guaiol 23.12 µM 0.573659557951622 0.281726761272473 no 981 0.283099100213338 1381 227829
SGTC_1154 4088-0362 150 µM 0.573205044699853 0.281886429439909 no 982 0.283252934540997 1356 6618304
SGTC_94 0334-0113 514.748 µM 0.572055407924776 0.282290485427728 no 983 0.283642218895669 1324 6795178
SGTC_2605 digitonin 300 nM 0.572048303715747 0.282292983167892 no 984 0.283644625284548 1427 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_106 0092-0003 11.579 µM 0.571561425837566 0.282464187927727 no 985 0.283809567365312 1421 1072148
SGTC_2391 6285546 200 µM 0.571126698028908 0.28261709692613 no 986 0.283956881098361 1343 846083
SGTC_4 0960-0234 25.671 µM 0.568564856312748 0.283518993546548 no 987 0.284825740115573 1381 6821112
SGTC_1501 4491-0275 38.4 µM 0.564400474133506 0.284988001222377 no 988 0.286240808133843 1378 5104718
SGTC_442 cape 100 µM 0.564253142874437 0.285040039507711 no 989 0.286290932769022 1452 5281787
SGTC_308 4092-1169 104 µM 0.563495226237242 0.285307811791399 no 990 0.286548854921484 1395 2268590 YDL196W YDL196W
SGTC_1371 2421-0008 32.7 µM 0.56202324721826 0.285828204720832 no 991 0.28705009013132 1411 2827552
SGTC_2199 6590217 200 µM 0.561711813871348 0.285938364462337 no 992 0.287156191956065 1399 703109
SGTC_381 3461-2219 42.7 µM 0.561161178472447 0.286133183770624 no 993 0.287343832638552 1439 2883159
SGTC_3003 9075612 71.4286 µM 0.560071606194753 0.286518869081312 no 994 0.287715298347515 1395 6501993
SGTC_1935 st074532 41.6 µM 0.559834102541402 0.286602973030763 no 995 0.287796300106599 1475 2829742
SGTC_1885 st057546 99.9 µM 0.557887938253296 0.287292582512507 no 996 0.288460454219892 1477 702008
SGTC_1908 st060353 56.5 µM 0.5577257835128 0.28735007630948 no 997 0.288515824239591 1504 4227716
SGTC_158 k038-0087 26.446 µM 0.55645976852397 0.287799143286462 no 998 0.288948294984538 1415 X158
SGTC_1195 1502-0147 41.1 µM 0.55225541745711 0.289292838247985 no 999 0.290386685431826 1392 817940
SGTC_1687 st020778 55.3625 µM 0.551163497069783 0.28968136389347 no 1000 0.290760800349936 1426 4259299
SGTC_353 1988-1175 58.3 µM 0.550136561908888 0.290046989902526 no 1001 0.291112855479759 1345 2788357
SGTC_2289 7946404 165.07 µM 0.549909976438558 0.290127691634827 no 1002 0.291190560579828 1422 1246120 YPR165W RHO1
SGTC_597 k018-0003 82.8 µM 0.549384426024555 0.290314914604715 no 1003 0.291370829828079 1509 6786234
SGTC_2884 9058502 51.95 µM 0.549089537942475 0.290419990809444 no 1004 0.291472002303176 1389 6471554
SGTC_2415 st077333 57.7 µM 0.54832499660269 0.290692499429446 no 1005 0.291734383321402 1613 2766255
SGTC_1794 st048918 76.9 µM 0.547513390193926 0.290981914441421 no 1006 0.292013036864934 1376 672303
SGTC_424 splitomicin 100 mM 0.547488179763046 0.29099090651754 no 1007 0.292021694492611 1376 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_233 rapamycin 362 pM 0.547481657776116 0.290993232806056 no 1008 0.292023934256989 1440 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_321 4534-3890 65.3 µM 0.546003419779955 0.291520720702266 no 1009 0.292531793239456 1443 699746
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.545385127537403 0.291741481553554 no 1010 0.292744333528422 1488 551469
SGTC_3226 9131256 49.47 µM 0.543662689568075 0.292356887379619 no 1011 0.293336805891056 1327 17178073
SGTC_1117 retinoic acid 1.10837 µM 0.543525198431755 0.292406037270458 no 1012 0.29338412308464 1520 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2567 aureobasidin a 60 nM 0.543341699766864 0.29247163976949 no 1013 0.293447279150607 1502 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3321 9137793 26.8275 µM 0.543090536872522 0.292561443955959 no 1014 0.293533733913035 1403 4904192
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.542086805499275 0.292920459536736 no 1015 0.293879353915255 1365 6708514
SGTC_2463 5473429 200 µM 0.540638807829148 0.293438740632279 no 1016 0.294378281779532 1432 5399405
SGTC_1614 st002383 48.6 µM 0.540423560761543 0.293515820163042 no 1017 0.294452481546148 1427 1947235
SGTC_3107 9121808 49.47 µM 0.54027082918115 0.293570518713437 no 1018 0.294505136268334 1391 662681
SGTC_3211 9128781 49.47 µM 0.539977297706864 0.293675655907728 no 1019 0.294606344423029 1421 17194361
SGTC_3241 9133421 49.47 µM 0.539797638927726 0.293740014741581 no 1020 0.294668297768352 1437 17018221
SGTC_2983 9022671 12.99 µM 0.538694469808465 0.294135343990261 no 1021 0.295048845118463 1545 6405161
SGTC_166 k072-0058 166.424 µM 0.538453259960782 0.294221816164466 no 1022 0.295132082608938 1412 5846229
SGTC_2508 celastrol 40.54 µM 0.537264784381828 0.294648048377476 no 1023 0.29554236348959 1378 122724 Celastrol is a natural product and antioxidant.
SGTC_2072 5231554 129 µM 0.537088936433437 0.294711138272232 no 1024 0.295603091294746 1491 789545
SGTC_456 gingerol 170 µM 0.53586072334844 0.295151964360188 no 1025 0.296027405578582 1480 442793 A herb.
SGTC_3178 9107506 49.47 µM 0.534076115872901 0.295793030143558 no 1026 0.296644436744995 1452 8897194
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.532224407880023 0.296458875116201 no 1027 0.29728528999734 1490 5024745
SGTC_1242 0402-0103 60.1 µM 0.53101337312765 0.296894715301031 no 1028 0.297704756025539 1399 432868
SGTC_1060 3448-7350 82 µM 0.530292346796953 0.297154345167008 no 1029 0.297954626049535 1534 570178
SGTC_803 4488-1585 147 µM 0.529676830036553 0.297376064840159 no 1030 0.298168007582782 1434 747204
SGTC_3129 9127257 49.47 µM 0.528447979709326 0.297818943648251 no 1031 0.298594221863132 1337 837894
SGTC_566 0958-0068 16.5 µM 0.526618672252406 0.298478784364469 no 1032 0.299229211320715 1444 6815365
SGTC_101 0490-5701 117.494 µM 0.526028841779646 0.298691681006031 no 1033 0.299434083909751 1423 4661669
SGTC_1807 st050092 58.9 µM 0.52524937568622 0.29897313161616 no 1034 0.299704922328387 1422 5008496
SGTC_3351 9150312 21.596 µM 0.524239169089081 0.299338077397201 no 1035 0.300056100357672 1440 4904905
SGTC_645 0845-0943 5.41 µM 0.524097045704017 0.299389436895289 no 1036 0.300105521630374 1431 1885106
SGTC_2819 7996655 46.38 µM 0.523620054759308 0.299561837560502 no 1037 0.300271414974478 1460 6456960
SGTC_885 0865-0106 16.8 µM 0.523379751185031 0.299648708441374 no 1038 0.300355006187544 1394 2793380
SGTC_1743 st037606 46.3785 µM 0.52298024455903 0.299793157233955 no 1039 0.300494000519872 1475 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_705 1124-0212 310 µM 0.521721448430865 0.300248503625929 no 1040 0.300932144380224 1527 9554485
SGTC_3280 9140961 49.47 µM 0.521349055057797 0.300383269995227 no 1041 0.301061816966086 1443 4901226
SGTC_1499 4480-0877 67.3 µM 0.520939860925066 0.300531385791424 no 1042 0.301204333124299 1428 2861909
SGTC_2580 diallyl disulphide 81.36 µM 0.518927997117739 0.30126009834703 no 1043 0.301905476598743 1481 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1073 triclabendazole 3.09 µM 0.518706313590604 0.301340442478871 no 1044 0.30198277912655 1481 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_532 1548-0774 215 µM 0.516792806218403 0.302034350177638 no 1045 0.302650401169423 1558 5932993
SGTC_644 1498-1197 63.3 µM 0.515176371898004 0.302621086839927 no 1046 0.303214889270364 1511 6741615
SGTC_835 0312-0010 67.2 µM 0.515169984781709 0.302623406261378 no 1047 0.303217120700391 1427 1626196
SGTC_231 b-estradiol 524 µM 0.513980565463509 0.303055471531309 no 1048 0.3036327891996 1399 450 A steroid.
SGTC_2908 7930301 100 µM 0.511393687846076 0.303996125195979 no 1049 0.304537706981326 1377 2223178
SGTC_1724 st037281 8.293 µM 0.509936010656088 0.304526745951913 no 1050 0.305048146210748 1453 574124 YDL195W SEC31
SGTC_3295 9122362 53.5725 µM 0.507008420710499 0.30559368424567 no 1051 0.30607445508178 1451 4730473
SGTC_2826 7992541 19.48 µM 0.506459726810225 0.305793835831089 no 1052 0.306266977474741 1519 2985066
SGTC_2526 patulin 37.61 µM 0.504811558375417 0.306395400522166 no 1053 0.306845598420041 1519 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1417 3966-0327 90.4 µM 0.504021978446197 0.306683774260869 no 1054 0.307122966207531 1513 651118
SGTC_1382 3002-2117 298 µM 0.503295686579914 0.306949139372775 no 1055 0.307378199320054 1583 1497314
SGTC_817 1391-0715 46 µM 0.503165128981892 0.306996851907816 no 1056 0.307424089701389 1449 1353946
SGTC_2359 9039622 200 µM 0.501435829629174 0.307629135948867 no 1057 0.308032214483659 1500 6463596
SGTC_2366 9070441 60.58 µM 0.50027384644914 0.308054313446624 no 1058 0.308441133487801 1424 6837235
SGTC_1937 st074714 47.2 µM 0.500244758444805 0.308064960253127 no 1059 0.308451373037551 1424 17250970
SGTC_2036 5160441 105 µM 0.49852123647652 0.308696092740877 no 1060 0.309058352415654 1525 134534 YIL048W NEO1
SGTC_1338 1486-1223 76 µM 0.495453436201858 0.309820881670173 no 1061 0.310140041457525 1551 3444526
SGTC_1716 st033144 30.6155 µM 0.494623425200365 0.310125506645925 no 1062 0.310432981770037 1573 674617
SGTC_979 1426-2828 121 µM 0.494031050042411 0.310342995866916 no 1063 0.310642125536595 1568 747872
SGTC_1443 4112-3303 14 µM 0.493583746953 0.31050726616377 no 1064 0.31080009077588 1485 704433
SGTC_2125 5246583 200 µM 0.49330950154079 0.310608000404095 no 1065 0.310896957886874 1609 835267
SGTC_396 dithiazanine 1.25 µM 0.491415033578791 0.311304253018674 no 1066 0.311566466728599 1445 10578 An antihelmenthic.
SGTC_2090 5301565 104.445 µM 0.490616761034178 0.311597835656632 no 1067 0.311848764718468 1507 2056344
SGTC_1227 3909-8010 46.6 µM 0.48614642171398 0.31324411309954 no 1068 0.313431677780506 1518 15982272
SGTC_2717 st081029 62.2815 µM 0.486047464753964 0.313280597962646 no 1069 0.313466756734722 1495 5292846
SGTC_2340 7987427 183.45 µM 0.485845904060174 0.313354917885693 no 1070 0.313538212595077 1537 2239331
SGTC_148 3253-0744 288.01 µM 0.485129602604843 0.313619095524391 no 1071 0.313792207288938 1463 6893655
SGTC_382 3229-0966 23.2 µM 0.483241029220786 0.314316074419831 no 1072 0.314462303059114 1589 5722370
SGTC_3072 9116419 49.47 µM 0.481381769261279 0.315002882474859 no 1073 0.315122595632398 1458 17170162
SGTC_311 1315-0136 58 µM 0.480069226156757 0.315488119727201 no 1074 0.3155890847746 1580 6759207
SGTC_1053 3366-3204 134 µM 0.479911216444788 0.315546556206817 no 1075 0.315645262630663 1472 3632071 YPR165W RHO1
SGTC_1277 0873-0036 22 µM 0.479844573609463 0.315571204003385 no 1076 0.31566895771497 1613 5965735
SGTC_2029 5175081 200 µM 0.478719974655973 0.315987259651842 no 1077 0.316068926874256 1493 1380876
SGTC_1698 5-fluorocytosine 1.055 µM 0.47829076998644 0.316146109346646 no 1078 0.31622163243925 1556 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1710 st031758 61.5 µM 0.475550453291204 0.317161106396435 no 1079 0.317197340442914 1594 5394341
SGTC_1305 1181-0477 144 µM 0.475407852610509 0.31721396259864 no 1080 0.317248149241247 1605 6252086
SGTC_525 k781-2675 26.7 µM 0.474290031464581 0.317628421986678 no 1081 0.317646549562354 1533 3651118 YDL195W SEC31
SGTC_706 4262-0057 46.9 µM 0.473400781859094 0.317958296261199 no 1082 0.317963636083409 1465 883298
SGTC_1818 st052136 56.3 µM 0.473399775359295 0.317958669712287 no 1083 0.317963995054407 1458 674169
SGTC_3115 9123671 49.47 µM 0.472793621533597 0.318183610284174 no 1084 0.318180212588573 1588 3286988
SGTC_418 lividomycin a 100 µM 0.472433949505326 0.318317114439018 no 1085 0.318308538364 1561 72394 An antibiotic.
SGTC_20 0481-0013 4.944 µM 0.471985501955574 0.31848360361791 no 1086 0.318468568504637 1491 182045
SGTC_1141 3253-0389 52.6 µM 0.471378748674011 0.318708923221535 no 1087 0.318685144541264 1542 5402031
SGTC_1847 st056231 15 µM 0.470749082169795 0.318942822606245 no 1088 0.318909964785539 1507 5393180
SGTC_556 4058-0063 51.5 µM 0.46968679966595 0.319337587350326 no 1089 0.31928940010715 1559 6615692
SGTC_1613 st002381 52.1 µM 0.469529157614806 0.31939618765767 no 1090 0.319345724212529 1502 551167
SGTC_613 3914-0030 117 µM 0.469195765970095 0.319520134249788 no 1091 0.319464855818204 1466 1145395
SGTC_2394 5221648 200 µM 0.467902740490188 0.320001039127184 no 1092 0.319927071809607 1675 788586
SGTC_994 3910-0338 138 µM 0.466814344824816 0.320406072259303 no 1093 0.320316355924248 1619 3479481
SGTC_3029 9088683 49.47 µM 0.46667770944353 0.320456934574531 no 1094 0.320365239988877 1528 25236615
SGTC_1387 3342-1166 1.8 µM 0.466454805005974 0.320539917654212 no 1095 0.320444995239455 1537 3418228
SGTC_330 1488-0319 80.1 µM 0.466377391317573 0.320568739396165 no 1096 0.320472695812373 1545 6846614
SGTC_513 4245-1575 41.7 µM 0.465017127507308 0.321075353010984 no 1097 0.320959595623735 1613 719745
SGTC_1031 k035-0009 16 µM 0.464787526226605 0.321160898094274 no 1098 0.32104181069391 1652 5180959
SGTC_742 0kpi-0133 140 µM 0.463693374481213 0.321568688603153 no 1099 0.32143372237462 1629 2728852
SGTC_3308 9128332 17.569 µM 0.463516232342483 0.321634729747321 no 1100 0.321497191223256 1652 17332805 YDL196W YDL196W
SGTC_2844 9010103 25.97 µM 0.462612033312062 0.321971915968626 no 1101 0.321821240873982 1526 2480525
SGTC_2735 sertaconazole 140 nM 0.461057642411277 0.322551908788921 no 1102 0.322378625048516 1593 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1788 fluconazole 20 µM 0.460273788747726 0.322844553572282 no 1103 0.322659856315541 1508 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1164 k060-0068 93.7 µM 0.456436018368649 0.324278932017192 no 1104 0.324038234998085 1562 5963676
SGTC_925 2064-1272 59.6 µM 0.455634650747828 0.32457877594074 no 1105 0.324326360779708 1523 6815817
SGTC_1844 rapamycin 4 nM 0.452530701943842 0.325741237776189 no 1106 0.325443354299104 1545 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2626 ethyl orsellinate 100 µM 0.451639224200502 0.326075419752746 no 1107 0.325764453947185 1508 75653 A natural product.
SGTC_1336 1486-0901 104 µM 0.451301888188828 0.326201910981074 no 1108 0.325885992088324 1583 5006114
SGTC_2262 9014885 67.46 µM 0.449116013906417 0.327022034536907 no 1109 0.32667398446458 1593 6457424
SGTC_3101 9120531 49.47 µM 0.448691055921729 0.327181572765089 no 1110 0.326827268796214 1625 24824904
SGTC_2054 5233173 129 µM 0.448466979559272 0.327265708495675 no 1111 0.32690810595899 1584 6889
SGTC_341 1486-1430 230 µM 0.448015848084065 0.3274351250316 no 1112 0.327070879528967 1496 2054753 YPL210C SRP72
SGTC_3087 9117406 49.47 µM 0.446365755141146 0.32805509845788 no 1113 0.327666532636847 1544 42546093
SGTC_1201 1889-3372 45.9 µM 0.44496980879792 0.328579954095015 no 1114 0.328170786260123 1557 5392199
SGTC_545 4218-0007 221 µM 0.444702367286337 0.328680546891285 no 1115 0.328267429164368 1562 2840508
SGTC_2772 vinpocetine 57.06 µM 0.444661598167126 0.328695882473921 no 1116 0.328282162539635 1607 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2026 5148700 152 µM 0.443451903862354 0.329151048425812 no 1117 0.328719450175744 1538 79838
SGTC_2432 5630864 12.22 µM 0.439270003788407 0.330726500735699 no 1118 0.330232953189431 1534 5714970
SGTC_1525 8-methoxypsoralen 92.5 µM 0.439152536016513 0.330770798006255 no 1119 0.330275507119348 1742 4114 Related to psoralen; DNA damaging agent.
SGTC_2155 5570423 76 µM 0.438554483128507 0.330996361372329 no 1120 0.330492192067089 1566 797402
SGTC_3265 9137266 49.47 µM 0.436837940592268 0.331644118108837 no 1121 0.331114440718517 1701 17224265
SGTC_2248 tofa 1.1 µM 0.436171763723841 0.331895643282226 no 1122 0.331356056410048 1588 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2489 cantharidin 73.42 µM 0.435825971951482 0.332026232091607 no 1123 0.331481499317741 1519 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3113 9123498 49.47 µM 0.432255651963068 0.333375759608224 no 1124 0.332777807736279 1608 8897275
SGTC_2131 toluylene red 5.2905 µM 0.432247042188782 0.333379016591088 no 1125 0.332780936190289 1510 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1781 st038725 66.3 µM 0.429834032565123 0.334292325917743 no 1126 0.333658187362506 1578 4270275 YIL048W NEO1
SGTC_2705 st078069 42.8 µM 0.429262316578094 0.334508860983764 no 1127 0.333866168622705 1556 1530061
SGTC_1809 st050081 57.6 µM 0.428975949642031 0.334617341978904 no 1128 0.333970363590092 1642 5036894
SGTC_216 k038-0035 28.382 µM 0.428895838205212 0.334647692117749 no 1129 0.333999514528122 1607 4444231 YPR107C YTH1
SGTC_1729 st035615 45.989 µM 0.428799260301116 0.334684281997801 no 1130 0.33403465861347 1559 17385451
SGTC_578 3460-0051 92 µM 0.428604278839274 0.334758158215961 no 1131 0.334105615562998 1664 2876744
SGTC_2777 climbazole 1.536 µM 0.42853559248902 0.334784184202363 no 1132 0.334130613064125 1621 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3186 9110464 49.47 µM 0.42753683857688 0.335162712266124 no 1133 0.334494179608556 1622 17018021
SGTC_234 nsc-17383 10.7 µM 0.427189501398077 0.335294392436748 no 1134 0.334620653744478 1659 408974
SGTC_2582 agaric acid 100 µM 0.425564239528566 0.335910819657725 no 1135 0.335212701317304 1518 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_127 0180-0333 59.125 µM 0.424949938585353 0.336143926033808 no 1136 0.335436584542899 1582 771601
SGTC_2442 5158906 48.48 µM 0.424309413097989 0.336387050853594 no 1137 0.335670087603715 1684 1893835
SGTC_2706 st078239 82.5 µM 0.42385398146785 0.336559961069087 no 1138 0.335836153458236 1576 15434492
SGTC_2383 9036125 200 µM 0.42366351909189 0.336632282702998 no 1139 0.335905612024079 1623 79580
SGTC_35 0133-0054 64.071 µM 0.423513048497373 0.336689423085918 no 1140 0.335960490193607 1503 99677
SGTC_562 3772-2733 112 µM 0.4225269190146 0.337063993622392 no 1141 0.33632022825071 1644 2876874 YIL048W NEO1
SGTC_1997 st073024 93.8 µM 0.422121708137332 0.337217955426391 no 1142 0.336468091841436 1623 686268
SGTC_2694 st077685 81.9 µM 0.420794313955579 0.337722496009634 no 1143 0.336952642030999 1540 2838096
SGTC_19 0279-0214 38.434 µM 0.419250833378473 0.33830953758301 no 1144 0.3375164124804 1630 3566274 YBR002C RER2
SGTC_621 3584-0052 32.1 µM 0.418504080097787 0.338593696151323 no 1145 0.337789302030826 1687 2273927
SGTC_997 3996-0078 137 µM 0.418367098853554 0.338645830971022 no 1146 0.337839368990747 1601 735687
SGTC_137 0438-0332 85.389 µM 0.4176467116313 0.338920059944287 no 1147 0.338102719383859 1577 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_667 1498-1044 59 µM 0.416902075720487 0.339203609385475 no 1148 0.338375017607606 1637 6739982
SGTC_2519 cryptotanshinone 88.04 µM 0.416436227609528 0.339381045724842 no 1149 0.338545411795838 1670 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1988 st071872 53.4 µM 0.415633718374974 0.339686796034154 no 1150 0.338839024702972 1665 16414116
SGTC_1573 oleylamine 1.06 µM 0.413769100955081 0.340397609138723 no 1151 0.33952160753923 1580 5356789 An amine of the fatty acid oleic acid.
SGTC_1497 4476-2978 41.3 µM 0.413471749553744 0.340511015352729 no 1152 0.339630508096212 1613 1528379
SGTC_695 3505-6186 243 µM 0.412673039383447 0.340815705085694 no 1153 0.339923090158636 1656 1819379
SGTC_988 1497-1057 103 µM 0.41117181901201 0.341388667431856 no 1154 0.340473275377033 1698 3533044
SGTC_3131 9127911 49.47 µM 0.409226237497228 0.34213177069617 no 1155 0.341186820662886 1655 45595681
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.408882668530799 0.34226305845557 no 1156 0.341312884264848 1637 688788
SGTC_2832 7992762 51.95 µM 0.408091259911181 0.342565551379779 no 1157 0.341603338221136 1446 2985177
SGTC_2667 digitoxin 100 µM 0.407990542685676 0.342604054857889 no 1158 0.341640309065824 1669 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2677 mitomycin C 100 µM 0.405832104338197 0.343429602974412 no 1159 0.342432983941035 1618 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_873 0591-4978 488 µM 0.404791023839654 0.343828057439027 no 1160 0.342815563676693 1776 3305145
SGTC_2300 7976697 71.57 µM 0.404454526683475 0.343956882683053 no 1161 0.34293925527604 1552 2236109
SGTC_661 1304-0007 33.6 µM 0.4043546066063 0.343995139774283 no 1162 0.342975987726676 1591 3117130
SGTC_584 0986-0246 15.4 µM 0.403494608456313 0.344324479206705 no 1163 0.343292200125125 1677 53315 YDR232W HEM1
SGTC_1000 4048-0884 8.67 µM 0.403181223874859 0.344444520344346 no 1164 0.343407455677455 1656 13040088
SGTC_3180 9109287 49.47 µM 0.403082824676363 0.344482215130926 no 1165 0.343443647616316 1625 18891271
SGTC_290 2043-6722 48.1 µM 0.402646739284108 0.344649289404943 no 1166 0.343604060260571 1640 773758 YLR208W SEC13
SGTC_1104 tacrolimus 29.8 µM 0.402525590381255 0.344695709697302 no 1167 0.343648629505578 1627 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1134 3477-0009 42.5 µM 0.401924331577403 0.344926126971887 no 1168 0.34386985764153 1807 3973534
SGTC_1287 0971-0001 34.6 µM 0.401009507244587 0.345276820647106 no 1169 0.344206562129278 1656 4665869
SGTC_2076 5212012 200 µM 0.400715555637985 0.345389533860528 no 1170 0.344314778345691 1621 604802
SGTC_2371 9071574 200 µM 0.400127560394621 0.345615036714947 no 1171 0.344531282903832 1664 45596039
SGTC_3006 9075424 71.4286 µM 0.398538833217246 0.34622460547784 no 1172 0.345116519576814 1569 7465181
SGTC_559 1550-0661 158 µM 0.398058695204145 0.34640890512519 no 1173 0.345293460179073 1681 5830875
SGTC_740 k014-0057 261 µM 0.397574036389337 0.346594976955093 no 1174 0.345472101088235 1748 4012779
SGTC_526 4469-0568 170 µM 0.396625524069723 0.346959240050346 no 1175 0.345821813835464 1589 2901964
SGTC_553 k007-0256 45.7 µM 0.396289717429775 0.347088235894189 no 1176 0.345945655971529 1657 6287000
SGTC_2663 amphotericin b 100 µM 0.395568283408632 0.347365425497365 no 1177 0.346211769359645 1633 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3163 9099914 49.47 µM 0.394792068185581 0.347663754340003 no 1178 0.346498174559534 1692 16268368
SGTC_1879 gemcitabine 100 µM 0.394261225081089 0.347867831749197 no 1179 0.346694093758733 1664 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1980 st071811 45.7 µM 0.394236780099639 0.347877230443931 no 1180 0.346703116699117 1705 4974850
SGTC_1882 5615643 20 µM 0.39386491108335 0.348020219509565 no 1181 0.346840388802622 1601 2253075
SGTC_197 4544-0043 41.561 µM 0.390763700465828 0.349213520222749 no 1182 0.347985954332379 1633 896523
SGTC_1571 st070080 73.4 µM 0.390609109384551 0.349273043764715 no 1183 0.348043095622679 1741 4315245
SGTC_1509 1326-1131 80 µM 0.390295863184961 0.349393667026399 no 1184 0.348158890966185 1749 768313
SGTC_1124 fisetin 1.16336 µM 0.389645783309926 0.349644045025863 no 1185 0.348399246224149 1613 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2646 retinol 96.75 µM 0.388214460308856 0.350195548945136 no 1186 0.34892866647718 1661 445354 A vitamin A analog and teratogen.
SGTC_2245 6637752 200 µM 0.386987061457563 0.350668730517229 no 1187 0.349382893304356 1782 681890
SGTC_1942 st076330 65.2 µM 0.386259640210858 0.350949272285576 no 1188 0.349652193945764 1683 24208414
SGTC_1174 0739-0097 51.1 µM 0.385864523351934 0.351101689563471 no 1189 0.349798502980691 1660 728447
SGTC_224 benfluorex 43.875 µM 0.382949604661208 0.352226865308087 no 1190 0.350878565249371 1754 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_978 1416-0512 87.4 µM 0.382670758100768 0.352334569726273 no 1191 0.350981949363432 1676 6814003
SGTC_2769 toremifene 3.73 µM 0.38247702156124 0.352409407392068 no 1192 0.351053784898233 1678 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_120 rhodamine 6G 52.259 µM 0.381680460045579 0.352717167779128 no 1193 0.351349197704358 1615 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.380990467231347 0.352983832104309 no 1194 0.351605161053114 1652 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2864 9034755 47.6 µM 0.37869771573269 0.353870439183949 no 1195 0.352456174913436 1663 4930451
SGTC_3074 9116018 49.47 µM 0.378541921515437 0.353930713641126 no 1196 0.352514028821048 1678 17027303
SGTC_891 0929-0073 133 µM 0.378463682605454 0.353960984488539 no 1197 0.352543083989259 1729 5603632
SGTC_1318 1280-3875 124 µM 0.377432708491621 0.354359957343235 no 1198 0.352926031673604 1673 373245
SGTC_2449 5812982 45.77 µM 0.376876894807311 0.354575115985132 no 1199 0.353132546399454 1660 776185
SGTC_650 1328-0195 38 µM 0.375085603183869 0.355268850671458 no 1200 0.353798401858259 1756 2780821
SGTC_1638 st008370 60.6 µM 0.374391556564299 0.355537771437784 no 1201 0.354056511917804 1617 24207134
SGTC_3143 9086658 49.47 µM 0.373708186633874 0.355802625613231 no 1202 0.354310716945125 1652 25236626
SGTC_2016 5121758 140 µM 0.373004063592358 0.356075595911484 no 1203 0.354572709782913 1636 2795203
SGTC_1662 st014054 52 µM 0.372094038130586 0.356428498546081 no 1204 0.354911417525242 1674 2838777
SGTC_1373 2887-0003 58.5 µM 0.370366346003125 0.35709882575097 no 1205 0.355554772864228 1660 776948
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.369477085381666 0.357444022126251 no 1206 0.35588607499987 1735 5282309
SGTC_214 4373-3496 70 µM 0.368747938997362 0.357727151852655 no 1207 0.356157806361637 1746 3779166
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.368082914958832 0.357985450961091 no 1208 0.356405704932889 1679 4000243
SGTC_1616 st002734 56.1 µM 0.367257963514923 0.358305957137202 no 1209 0.356713303381799 1699 4026101
SGTC_23 0213-0011 39.996 µM 0.365804008541945 0.358871083725117 no 1210 0.35725566425555 1777 627608
SGTC_2012 4023501 200 µM 0.365293063877935 0.359069752332177 no 1211 0.357446327715846 1630 3477460
SGTC_2108 5365811 200 µM 0.362698848355462 0.360079038076163 no 1212 0.358414930052062 1741 780283
SGTC_1600 coumarin 106 71.1 µM 0.361132970369051 0.36068871956458 no 1213 0.359000023617074 1716 100336 A hepatotoxic, DNA x-linker.
SGTC_1516 st013856 110 µM 0.36111360156415 0.360696263115268 no 1214 0.359007262886041 1677 5281404 A mutagen and neurotoxin.
SGTC_1863 st057641 20.1 µM 0.361038884993664 0.360725363417311 no 1215 0.359035189365814 1780 3921635
SGTC_2260 7964312 200 µM 0.361022298716035 0.360731823481776 no 1216 0.359041388847115 1791 231951
SGTC_1205 4161-2785 76 µM 0.360852582684696 0.360797927185155 no 1217 0.359104826030876 1600 3498106
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.360372663145592 0.360984876394909 no 1218 0.359284233429467 1565 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2332 7982454 138.89 µM 0.360264720475734 0.361026929263788 no 1219 0.35932458970613 1683 2981748
SGTC_1959 st077091 55.8 µM 0.35870294187564 0.361635562877398 no 1220 0.359908663681474 1663 821356 YKL052C ASK1
SGTC_3327 9140648 26.9345 µM 0.358212844968965 0.361826628576537 no 1221 0.360092017655289 1806 8029710
SGTC_1098 clofazimine 15.1 µM 0.357272216512878 0.362193431773385 no 1222 0.360444013650283 1754 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1416 3966-0321 25.3 µM 0.356823411615212 0.362368490318483 no 1223 0.360612004272155 1707 582530 YLR208W SEC13
SGTC_1334 1486-0610 236 µM 0.355900644846322 0.362728510405596 no 1224 0.360957486430827 1721 3742339
SGTC_3247 9135149 49.47 µM 0.355534874550369 0.362871250341894 no 1225 0.361094461568063 1691 8934436 YOR116C RPO31
SGTC_1257 0669-0121 16 µM 0.355258032117828 0.362979299316858 no 1226 0.361198146484751 1797 4307855
SGTC_1826 st055655 41.6 µM 0.354400278120489 0.363314141785458 no 1227 0.361519463080711 1698 676168
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.35229416376206 0.364136750944274 no 1228 0.362308832298671 1675 91467 include heat shock
SGTC_949 1165-0505 146 µM 0.35186678711711 0.364303752894513 no 1229 0.362469084178518 1670 6244267
SGTC_702 1488-0190 94 µM 0.351020354742032 0.364634581329902 no 1230 0.362786538982824 1841 949357
SGTC_1902 st060212 70.5 µM 0.350217469211622 0.364948482659587 no 1231 0.363087748708116 1680 688944
SGTC_186 3455-3465 67.277 µM 0.349798686174648 0.365112248730362 no 1232 0.363244892554903 1699 755278
SGTC_93 0109-0045 59.227 µM 0.348635838729 0.3655671118322 no 1233 0.363681359235786 1773 88733
SGTC_1458 k015-0034 6.33 µM 0.348188382484904 0.365742190658738 no 1234 0.363849355999303 1635 3598957
SGTC_1674 st016616 23.6 µM 0.347835755324272 0.365880184861968 no 1235 0.363981767772208 1621 625830
SGTC_2860 9025725 38.96 µM 0.347818880639899 0.365886788896939 no 1236 0.363988104636646 1635 40546248
SGTC_2170 morpholine 200 µM 0.347399346940904 0.366050989344501 no 1237 0.364145661946846 1769 121171 Reacts with secondary amines.
SGTC_585 0kpi-0023 191 µM 0.347214528480847 0.366123332855317 no 1238 0.36421507843754 1804 64601
SGTC_1646 st011709 75.6 µM 0.347101170497891 0.366167706938356 no 1239 0.364257657088738 1807 5757843
SGTC_2775 cyproheptadine 69.59 µM 0.346780066130608 0.366293413242039 no 1240 0.364378276927189 1789 2913 A selective serotonin reuptake inhibitor.
SGTC_1518 st038567 90.8 µM 0.346608524730854 0.366360574346023 no 1241 0.364442720347473 1701 77966
SGTC_2866 9034245 58.44 µM 0.346592013493798 0.366367038966 no 1242 0.364448923370613 1827 6462273
SGTC_993 3909-8757 62.7 µM 0.345737886060771 0.366701505884131 no 1243 0.364769854565969 1717 4288324 YLR208W SEC13
SGTC_1742 st038235 28.8875 µM 0.34418906623625 0.367308264795985 no 1244 0.365352052216128 1706 564103 YBR002C RER2
SGTC_1461 k072-0203 53.8 µM 0.344096077349783 0.36734470428052 no 1245 0.365387016406213 1688 5418714
SGTC_1751 st044839 27.194 µM 0.339214894949415 0.369259159528188 no 1246 0.367223924620527 1760 5291326
SGTC_2356 9061756 188.97 µM 0.338866005033141 0.369396123017911 no 1247 0.367355337444373 1845 20104043
SGTC_750 4073-0104 132 µM 0.33748930211425 0.369936736014398 no 1248 0.367874037643079 1700 22330957
SGTC_534 k292-0788 63.4 µM 0.337013737580618 0.370123543711277 no 1249 0.368053272098357 1895 4146317
SGTC_2951 9072950 58.06 µM 0.337001311104253 0.370128425397608 no 1250 0.368057955870591 1782 16488155
SGTC_114 0364-0001 490.298 µM 0.33676715429319 0.370220416776835 no 1251 0.368146217635056 1664 4003655
SGTC_355 1311-2252 105 µM 0.335077621556007 0.370884390198874 no 1252 0.368783266726184 1680 5338538
SGTC_1487 3970-0795 2.82 µM 0.334601040868306 0.371071752394992 no 1253 0.368963029815299 1761 3765103
SGTC_3016 9080866 49.47 µM 0.334183081269076 0.371236093546449 no 1254 0.369120705013627 1679 17066299
SGTC_1275 0867-0008 21.1 µM 0.334070731115308 0.371280273481128 no 1255 0.369163092849821 1753 3422836
SGTC_352 k048-0007 5.11 µM 0.333994489403875 0.371310255303674 no 1256 0.369191858480097 1731 6811911
SGTC_251 melphalan 456.522 µM 0.333845270758893 0.371368937344509 no 1257 0.369248160075324 1823 460612 A DNA alkylator.
SGTC_2741 miltefosine 3.04 µM 0.333061576650223 0.371677183614121 no 1258 0.369543901239926 1741 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2466 5983409 37.09 µM 0.331676366227357 0.372222222292647 no 1259 0.370066824208731 1715 2879657
SGTC_626 0214-0009 33 µM 0.330169793184481 0.372815304218096 no 1260 0.370635834876816 1817 3437874
SGTC_3065 9113888 49.47 µM 0.329976456869015 0.372891435419611 no 1261 0.370708875704712 1798 16648368
SGTC_445 e6 berbamine 66 µM 0.329319254052494 0.373150263222683 no 1262 0.370957196209111 1722 6610268 A calcium/calmodulin antagonist.
SGTC_2362 9071156 126 µM 0.328886694698364 0.373320650390173 no 1263 0.371120665741694 1789 653133
SGTC_1557 sumaresinolic acid 42.3 µM 0.327617865593802 0.373820590951401 no 1264 0.371600306026595 1698 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3305 9127027 53.8275 µM 0.327215402333416 0.373979212824113 no 1265 0.371752486090218 1754 41905295
SGTC_512 prima-1 270 µM 0.326822360027204 0.374134142238313 no 1266 0.371901123231471 1805 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_317 4495-0002 170 µM 0.326546468299158 0.374242905384512 no 1267 0.372005468846387 1703 15991618
SGTC_1114 scopoletin 1.73284 µM 0.325211693694671 0.374769246813428 no 1268 0.372510429510663 1854 5280460 A coumarin with genotoxic properties.
SGTC_1791 st048313 56.1 µM 0.32506271415274 0.374828008384442 no 1269 0.372566803809447 1856 1204976
SGTC_839 0122-0028 230 µM 0.324722325316376 0.374962277875026 no 1270 0.372695618193944 1764 759448
SGTC_2595 hexamethylquercetagetin 100 µM 0.323622682068414 0.375396145707247 no 1271 0.373111856772402 1757 386331
SGTC_2731 amoxapine 43.43 µM 0.32324529199148 0.375545082559605 no 1272 0.373254741189138 1844 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_207 4185-0010 4.486 µM 0.321895662776369 0.376077864864962 no 1273 0.373765869532881 1835 3761753
SGTC_1735 st034310 56.75 µM 0.321484529871254 0.376240211503334 no 1274 0.373921616974881 1838 871153
SGTC_2989 9073649 71.4286 µM 0.318869846312808 0.377273199472054 no 1275 0.374912605400014 1897 21367202
SGTC_524 r073-0010 27.8 µM 0.31873508308693 0.377326464509985 no 1276 0.374963704317695 1713 2772106
SGTC_1479 0549-0158 134 µM 0.318302676391009 0.377497388601907 no 1277 0.375127677172156 1727 5440202
SGTC_406 estrone 100 µM 0.318184086513258 0.377544269653944 no 1278 0.375172651560348 1866 5870 A steroid.
SGTC_313 3474-0040 5.03 µM 0.317540749618238 0.377798625572693 no 1279 0.375416662173873 1724 1043375 YIL048W NEO1
SGTC_1320 1313-0481 95.3 µM 0.316438515037984 0.378234538857615 no 1280 0.37583484346217 1878 6813365 YLR208W SEC13
SGTC_2097 5376186 200 µM 0.315559992001993 0.378582089447488 no 1281 0.376168254408759 1843 742755
SGTC_2635 hydroquinidine 100 µM 0.311291897966336 0.380271973954194 no 1282 0.377789363009676 1753 442912 An experimental heart treatment.
SGTC_1136 pergolide 1.05886 µM 0.309968361288408 0.380796473679155 no 1283 0.378292508108951 1751 47811 A dopamine receptor agonist.
SGTC_860 0443-0016 25.1 µM 0.309278693665866 0.381069866559569 no 1284 0.37855476849748 1785 5337942
SGTC_2321 7390090 138.78 µM 0.307132444425739 0.381921045970162 no 1285 0.379371281645239 1698 649046
SGTC_2070 5230947 200 µM 0.306486582477635 0.382177299867683 no 1286 0.37961709712952 1871 2835538
SGTC_2673 kobusone 100 µM 0.306070615923105 0.382342367195144 no 1287 0.379775440044526 1810 6710676 An epoxy ketone and protein crosslinker.
SGTC_2979 9012552 45.46 µM 0.304816337982876 0.382840229596212 no 1288 0.380253018708717 1831 17100905
SGTC_924 2046-0044 21.3 µM 0.304566370026735 0.382939472914516 no 1289 0.38034821831328 1702 3623589
SGTC_2770 toltrazuril 17.5 µM 0.304157390934994 0.383101864066343 no 1290 0.380503992496896 1902 68591 Kills coccidiodes.
SGTC_426 0988-0037 14.6 µM 0.304029348863245 0.383152709274919 no 1291 0.380552765842784 1947 5383008
SGTC_1483 3453-0561 55.9 µM 0.302844440647098 0.383623328971893 no 1292 0.381004206999065 1836 4546991
SGTC_3134 9127454 49.47 µM 0.302713411258781 0.383675381544373 no 1293 0.381054138174379 1796 24262820
SGTC_3121 9125696 49.47 µM 0.302224682308424 0.383869551912051 no 1294 0.381240394857226 1876 1235365
SGTC_2192 5915882 198.485 µM 0.302064639484944 0.383933142727358 no 1295 0.38130139384035 1794 2876149
SGTC_2594 a-mangostin 100 µM 0.302022810826861 0.383949763284715 no 1296 0.381317336969553 1896 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_253 dyclonine 31.25 µM 0.300184752885945 0.384680323341391 no 1297 0.382018117264564 1841 3180 An oral anasthetic.
SGTC_1365 1672-3266 55.4 µM 0.299740779237107 0.384856847976762 no 1298 0.382187445294648 1888 6415873
SGTC_1264 0783-0040 158 µM 0.29825974622892 0.385445881514624 no 1299 0.382752462344151 1705 2855798
SGTC_2013 4024628 200 µM 0.298094223856384 0.385511729194117 no 1300 0.382815624989748 1831 5230760
SGTC_3059 1327-0034 3 µM 0.29805899766897 0.385525743210284 no 1301 0.382829067557911 1742 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1067 clotrimazole 1.36 µM 0.296492491749351 0.386149096307472 no 1302 0.383427000032397 1774 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_712 r015-0009 80.6 µM 0.295925174139185 0.386374919217629 no 1303 0.383643612723267 1862 6813872 YLR060W FRS1
SGTC_2043 5101342 149 µM 0.293742701457431 0.387244018918839 no 1304 0.384477260956614 1814 678451
SGTC_1178 0988-0033 191 µM 0.29178494650471 0.388024113322328 no 1305 0.385225527799287 1835 5392207
SGTC_1156 4092-0367 4.88 µM 0.291410653727049 0.388173307003446 no 1306 0.385368633731693 1812 1357585
SGTC_462 ag-879 158 µM 0.290828943867553 0.38840521020545 no 1307 0.38559107383917 1904 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_202 3594-0513 34.79 µM 0.289950695949762 0.3887554059881 no 1308 0.385926978453553 1858 708429
SGTC_1290 0986-0249 10.2 µM 0.288227597287663 0.389442743129749 no 1309 0.386586262575595 1893 53329
SGTC_1322 1348-1070 12 µM 0.287009421964223 0.389928877290334 no 1310 0.387052552962615 1901 6758089
SGTC_1025 k007-0731 70 µM 0.2865118608501 0.390127487332825 no 1311 0.387243055214633 1759 6256118
SGTC_1671 st016596 74.5 µM 0.286009415246306 0.390328076210666 no 1312 0.387435455161795 1796 2829167
SGTC_2733 amorolfine 100 µM 0.285848996826652 0.390392125416347 no 1313 0.387496889518552 1935 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1063 disulfiram 1.84 µM 0.285608245928583 0.390488254023398 no 1314 0.387589093547084 1817 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1172 0370-0043 85 µM 0.284382330042778 0.390977849527303 no 1315 0.388058699412031 1845 376585
SGTC_419 nsc-638432 893 µM 0.283780023958997 0.391218456603101 no 1316 0.388289482015355 1804 368090
SGTC_489 paxilline 115 µM 0.283484393898544 0.391336569079343 no 1317 0.388402771542088 1778 105008 A toxic potassium channel blocker.
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.282653117489928 0.391668740920312 no 1318 0.388721379011382 1894 140250 A respiratory chain inhibitor.
SGTC_2424 5537928 59.2 µM 0.282114008259279 0.391884207185022 no 1319 0.38892804613946 1753 5382802
SGTC_2608 thymoquinone 42.66 µM 0.280602791135733 0.392488373254187 no 1320 0.389507537498638 1861 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1462 k081-0014 26.5 µM 0.280506935014903 0.392526704112501 no 1321 0.389544302791696 1742 3270634
SGTC_3322 9139058 2.11 µM 0.279806638265594 0.392806769747136 no 1322 0.389812929229716 1870 4908926 YPR165W RHO1
SGTC_2024 5144227 134 µM 0.279471645872825 0.392940760955492 no 1323 0.389941447395332 1873 3475211
SGTC_1677 st019204 53.9 µM 0.279346858512146 0.392990677002207 no 1324 0.38998932452236 1743 3945625
SGTC_593 1203-0218 61.7 µM 0.278116845412315 0.393482787138162 no 1325 0.390461332451554 1918 3666956
SGTC_1819 st053448 58.6 µM 0.277840390381056 0.393593416181164 no 1326 0.390567442163796 1845 2857616
SGTC_2478 5763493 32.33 µM 0.277469908166598 0.39374168556118 no 1327 0.390709654420913 1863 1365576 YLR208W SEC13
SGTC_1473 k844-0725 134 µM 0.277131678600334 0.393877060676286 no 1328 0.390839499034113 1852 54682906
SGTC_2224 6650123 117.647 µM 0.276395006109238 0.394171955443593 no 1329 0.391122345968762 1828 2908370
SGTC_649 1123-0311 367 µM 0.276054234771769 0.394308388952802 no 1330 0.391253205324954 1913 693629 YIL048W NEO1
SGTC_2990 9074105 71.4286 µM 0.274460460942129 0.394946654888142 no 1331 0.391865392468531 1844 6502001
SGTC_410 α-linolenic acid 100 µM 0.273653874545445 0.395269779842231 no 1332 0.392175313892232 1909 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3232 9132874 49.47 µM 0.273345413544796 0.395393370834214 no 1333 0.392293854532163 1777 3784940
SGTC_1250 0485-0349 40.2 µM 0.272265938443989 0.395825966617896 no 1334 0.39270877221155 1800 6842794 YDL195W SEC31
SGTC_1429 4049-0205 9.46 µM 0.270750532475985 0.396433476594622 no 1335 0.393291454259294 1863 22774478
SGTC_2025 5147754 141 µM 0.270370084131763 0.396586033808723 no 1336 0.393437776370321 1932 315777 YLR208W SEC13
SGTC_1836 st055642 81 µM 0.270105004494238 0.396692338311505 no 1337 0.393539736066399 1762 8571
SGTC_1331 1472-0049 76.2 µM 0.26995120066365 0.396754021559392 no 1338 0.393598898208207 1782 24051409
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.269742520804618 0.396837717048 no 1339 0.393679172876162 1925 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3167 9103034 49.47 µM 0.26958400034662 0.396901298220137 no 1340 0.393740155318139 1837 5127859
SGTC_2888 9058547 12.99 µM 0.267042797576333 0.397920925500621 no 1341 0.394718104743712 1790 16476514
SGTC_779 1360-0071 233 µM 0.266425464919708 0.398168728444552 no 1342 0.394955777780471 1980 7566
SGTC_751 0833-0568 350 µM 0.263200210333042 0.39946404071588 no 1343 0.396198134347122 1861 6954252
SGTC_2795 7780010 54.55 µM 0.262990052149936 0.39954848208728 no 1344 0.396279123274079 1845 953673
SGTC_2739 tacrine 100.86 µM 0.261608312078827 0.400103780857049 no 1345 0.396811717518739 1845 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3176 9106582 49.47 µM 0.261373329434092 0.400198236676748 no 1346 0.396902311193826 1954 17018027
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.26113935807889 0.400292291789788 no 1347 0.396992520511356 1857 65057 A dermal irritant. YDR527W RBA50
SGTC_2214 7179297 48.276 µM 0.257633938038561 0.40170213955143 no 1348 0.398344717442681 1905 769744
SGTC_3219 9131112 49.47 µM 0.257067790178124 0.401929959592411 no 1349 0.398563220936036 1920 17612988 YMR079W SEC14
SGTC_2446 5162541 200 µM 0.2560108202627 0.402355377420013 no 1350 0.398971241158886 1807 1549321
SGTC_2096 5468907 200 µM 0.255163315943176 0.402696571422584 no 1351 0.399298481536361 1973 759785
SGTC_1315 1237-0019 3.69 µM 0.254549247144748 0.402943833704766 no 1352 0.399535631467371 1953 825140
SGTC_1954 st077032 68.9 µM 0.253842577057576 0.40322843106016 no 1353 0.399808589371452 1756 698907
SGTC_3196 9111891 49.47 µM 0.25283939373532 0.403632531247688 no 1354 0.400196162343222 1906 18891510
SGTC_1159 4092-0538 61.2 µM 0.25026101432776 0.404671619710017 no 1355 0.401192751692466 1868 717301
SGTC_554 4483-2211 187 µM 0.248837376178289 0.405245635454947 no 1356 0.401743289117929 1871 747107
SGTC_1808 st050063 61.5 µM 0.248061967545462 0.405558368702044 no 1357 0.402043230775843 1957 4011993
SGTC_2817 7995342 71.43 µM 0.247452470739366 0.405804229701967 no 1358 0.402279035339337 1797 18879975
SGTC_1960 st011366 51.8 µM 0.24741538420525 0.405819191000965 no 1359 0.402293384674835 1880 3972846
SGTC_1555 citronellol 128 µM 0.24699190625266 0.405990038505582 no 1360 0.402457243968059 2001 8842 A terpine precursor.
SGTC_1042 0350-0096 82 µM 0.246370873971382 0.406240619497372 no 1361 0.40269757533362 1813 3122515
SGTC_2330 7979373 200 µM 0.246123591268722 0.406340406561741 no 1362 0.402793280744983 1743 1863007
SGTC_63 0099-0242 26.702 µM 0.245894994601874 0.406432658580231 no 1363 0.402881759312628 2004 3898502 YLR359W ADE13
SGTC_620 0109-0052 432 µM 0.24420234689419 0.407115901422983 no 1364 0.403537054762174 1978 493037
SGTC_1829 berberine 14.4 µM 0.243598310401431 0.407359791311856 no 1365 0.403770968494457 1971 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1070 indatraline 8.81 µM 0.242751426080605 0.407701795555686 no 1366 0.40409898323254 1831 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2743 auranofin 4.32 µM 0.242071748543399 0.407976326213942 no 1367 0.404362284330253 1941 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3001 9076041 71.4286 µM 0.23970276640807 0.408933541495545 no 1368 0.40528034508882 1877 16004211
SGTC_2151 5563267 85.4165 µM 0.238653213694587 0.409357799738018 no 1369 0.405687249271077 1877 5310824
SGTC_327 1273-0057 3.96 µM 0.237056359018982 0.410003496099854 no 1370 0.406306533946455 1972 3108138
SGTC_2598 perillyl alcohol 100 µM 0.236582027099483 0.410195341742391 no 1371 0.406490532357433 1940 10819 An apoptosis inducer.
SGTC_177 1327-0068 8.361 µM 0.236137524691506 0.410375142218035 no 1372 0.406662978325603 1955 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1834 st055981 52.8 µM 0.23551755387364 0.410625950826085 no 1373 0.406903527983627 1989 471719 YDL150W RPC53
SGTC_295 k015-0027 31 µM 0.233007367220582 0.411641817033004 no 1374 0.407877842498025 1931 3887424
SGTC_451 chloral hydrate 100 µM 0.230339637528118 0.412722089944375 no 1375 0.408913931126169 1911 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2945 9067681 61.76 µM 0.230063738179859 0.41283385075548 no 1376 0.409021120934677 1957 16456930
SGTC_227 fluconazole 33.516 µM 0.22966141056269 0.412996837564309 no 1377 0.409177441653025 1860 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_579 4491-1009 110 µM 0.227443465485271 0.413895617077947 no 1378 0.410039462598844 2082 1271041
SGTC_3317 9138495 8.753 µM 0.225150853428698 0.414825128188158 no 1379 0.410930960550261 1952 17020139
SGTC_523 1934-0222 13.7 µM 0.22497453411319 0.414896634488587 no 1380 0.410999542645708 1844 1361595
SGTC_1898 st060199 18.6 µM 0.224960868850414 0.414902176553828 no 1381 0.411004858072364 1857 688866
SGTC_2132 5317594 122.667 µM 0.223782371670945 0.415380189850477 no 1382 0.411463323749057 1916 794577
SGTC_676 falcarinol 140 µM 0.22341217623686 0.415530371669261 no 1383 0.411607364270274 2026 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3329 9141233 27.5565 µM 0.221946703420869 0.41612500929222 no 1384 0.412177686505448 1993 4909101 YNL103W MET4
SGTC_3233 9132340 49.47 µM 0.221575389458032 0.416275706062799 no 1385 0.41232222132528 1874 17682950
SGTC_3168 9103419 49.47 µM 0.220844591228437 0.416572334485083 no 1386 0.412606720945215 2029 16649256
SGTC_1977 st070720 65.3 µM 0.220104113380586 0.416872940292121 no 1387 0.412895035674418 1895 682188
SGTC_854 0422-0053 192 µM 0.219057220002568 0.417298022041521 no 1388 0.413302737447466 1994 3596728
SGTC_906 1165-0455 526 µM 0.216890639572265 0.418178049310679 no 1389 0.414146786260687 1879 3252859
SGTC_1128 3448-9350 235 µM 0.216819865039606 0.418206803629822 no 1390 0.4141743650671 1863 619386
SGTC_1089 terbinafine 2.25 µM 0.216212953469439 0.418453397955324 no 1391 0.414410878468404 2033 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1345 1488-0192 31.4 µM 0.215730126013274 0.418649598544553 no 1392 0.414599058470132 2021 658348
SGTC_2854 9024559 71.43 µM 0.215485388075714 0.418749057389195 no 1393 0.414694451556646 1868 3163529
SGTC_3002 9075603 71.4286 µM 0.210953875338493 0.42059154691448 no 1394 0.416461631751067 2041 20105405
SGTC_799 1310-0557 151 µM 0.21056060323988 0.420751531990243 no 1395 0.416615078545192 1949 5354492
SGTC_972 1319-0219 195 µM 0.210557638416629 0.420752738145059 no 1396 0.416616235407361 1891 23903702
SGTC_3246 9135460 32.98 µM 0.210317726237143 0.42085034212143 no 1397 0.41670985057268 1990 41446951
SGTC_356 1634-0012 32.5 µM 0.209956562464998 0.420997284311716 no 1398 0.416850787740082 2092 735457
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.209343945954756 0.421246557092861 no 1399 0.417089873898498 1964 3256 An antibiotic and ribosome inhibitor.
SGTC_384 k007-0144 5.16 µM 0.208882343630253 0.421434403279299 no 1400 0.417270043935604 1947 6824886
SGTC_1435 4092-0789 56.7 µM 0.208703192271661 0.421507312626359 no 1401 0.417339973973442 2028 2248285
SGTC_43 0570-0105 72.5 µM 0.208400045307295 0.421630690675629 no 1402 0.417458310477241 1941 1114046 YDL195W SEC31
SGTC_2028 5153890 36.43 µM 0.208074960599221 0.421763005735261 no 1403 0.417585218909727 1930 2830968 YPR165W RHO1
SGTC_1260 0700-1617 7.75 µM 0.207476425508623 0.422006642889735 no 1404 0.417818900914548 1942 2853078
SGTC_1926 methyl fluorone black 53.6 µM 0.207053756129277 0.422178710883228 no 1405 0.417983938347584 1976 72721 Reacts with homocysteine.
SGTC_2810 7959871 45.46 µM 0.20684241241514 0.422264754126702 no 1406 0.418066466006382 1981 2974535
SGTC_3243 9134147 49.47 µM 0.205432979219998 0.422838663853471 no 1407 0.418616928006597 2061 24282180
SGTC_2948 9070189 9.45 µM 0.205118076015932 0.4229669123063 no 1408 0.418739937033808 2063 6473636 YDL196W YDL196W
SGTC_2290 7904846 200 µM 0.203213023852023 0.423742943359768 no 1409 0.419484266826084 1900 2962154
SGTC_2202 7226349 200 µM 0.199989063191329 0.425056909831786 no 1410 0.420744567324701 1952 844334
SGTC_1037 k284-1091 78.7 µM 0.199521800140704 0.425247418332955 no 1411 0.420927296057465 1913 3334711
SGTC_1783 st039459 87.517 µM 0.1990630874714 0.425434457726094 no 1412 0.421106697634563 2061 729761
SGTC_1072 oxiconazole 14.9 nM 0.198780256671698 0.425549789920855 no 1413 0.4212173203427 1991 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1300 1094-0077 113 µM 0.197576246964263 0.426040829828019 no 1414 0.421688310307442 1927 5532636
SGTC_2274 7947094 46.08 µM 0.197235808685786 0.426179694044274 no 1415 0.421821504843154 2106 2971028
SGTC_2062 5245942 200 µM 0.196772239517416 0.426368797863829 no 1416 0.422002888015855 2066 1376160
SGTC_142 0335-0849 62.6745 µM 0.195727777345818 0.426794927405645 no 1417 0.422411620861615 1983 3889043 YPR107C YTH1
SGTC_2593 nobiletin 86.24 µM 0.195656980460299 0.426823814885724 no 1418 0.42243932907061 1909 72344 An anti-infammatory.
SGTC_1973 st070275 50.2 µM 0.195583720525432 0.426853707784922 no 1419 0.422468001662329 2073 17118334
SGTC_3010 9080089 71.4286 µM 0.195313818935875 0.426963841741339 no 1420 0.422573639726503 2046 17027233
SGTC_2234 tolnaftate 200 µM 0.193993673384493 0.427502612005874 no 1421 0.423090417855843 2061 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_947 3447-0010 211 µM 0.193616107354596 0.427656727010485 no 1422 0.423238242503818 2033 748350
SGTC_1422 4031-0024 15.5 µM 0.193140282071816 0.427850965222502 no 1423 0.423424553002282 2058 782427
SGTC_872 0588-0139 234 µM 0.193005441462234 0.427906012135303 no 1424 0.423477353272699 2021 2047100
SGTC_136 0097-0015 404.482 µM 0.192939394105861 0.427932975615533 no 1425 0.423503216296473 2096 4861337
SGTC_2843 9000894 45.46 µM 0.192579964582732 0.428079716692963 no 1426 0.4236439685716 2013 2242070
SGTC_944 3370-0224 231 µM 0.192151996128728 0.428254452517595 no 1427 0.423811573335441 1917 4580514
SGTC_1964 st076914 61 µM 0.192113217110292 0.428270286351622 no 1428 0.423826760996653 2068 24208661
SGTC_831 k061-1017 217 µM 0.18862601259688 0.429694613489311 no 1429 0.425192971839191 2051 1240153
SGTC_429 1112-0049 25.5 µM 0.187772798090824 0.430043243808451 no 1430 0.425527380211546 1881 2836170
SGTC_2555 cholic acid 100 µM 0.187654661570779 0.430091519647508 no 1431 0.425573686795328 1992 6708657 Influences liver metabolism.
SGTC_2296 7971656 126.45 µM 0.185901949163838 0.430807878322603 no 1432 0.426260826818254 1955 666570
SGTC_2616 abietic acid 100 µM 0.18580061528284 0.430849301917858 no 1433 0.426300561004599 2122 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1695 st026914 34.495 µM 0.184458545607966 0.431397989137111 no 1434 0.426826872454932 1953 3289191
SGTC_1155 4088-0394 48.2 µM 0.184129416790287 0.431532569305299 no 1435 0.426955964870021 1918 2326248
SGTC_262 fenpropimorph 62.5 µM 0.183847284002222 0.431647939210723 no 1436 0.42706663051486 2033 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2311 7694451 200 µM 0.183788091695009 0.431672144904051 no 1437 0.427089849228669 2004 2163142
SGTC_2799 7812892 81.82 µM 0.183624274140686 0.431739136660677 no 1438 0.427154109451403 2058 20205235
SGTC_80 0159-0065 512.242 µM 0.182196227928878 0.43232320661784 no 1439 0.42771436656416 2095 1548079
SGTC_1438 4092-1045 4 µM 0.181919396356591 0.432436447705321 no 1440 0.427822991198704 2013 1351342
SGTC_104 0074-0074 590.992 µM 0.181030331256831 0.432800167335083 no 1441 0.428171884215389 2098 3943124
SGTC_3290 9121031 71.43 µM 0.180791921019365 0.432897711488578 no 1442 0.428265452353748 1957 17014854
SGTC_2886 9058944 51.95 µM 0.180696034778322 0.43293694393626 no 1443 0.428303085671683 2053 4949929
SGTC_767 0929-0023 86 µM 0.180692839184466 0.432938251444605 no 1444 0.428304339885791 2096 1204563
SGTC_413 propylparaben 100 µM 0.180202925267626 0.433138713170268 no 1445 0.428496630998117 1954 7175 A pharmaceutical preservative.
SGTC_2930 9013230 14.89 µM 0.179137096039289 0.433574885815652 no 1446 0.428915027335129 2057 2995857
SGTC_1502 4534-4282 27.7 µM 0.178908854295261 0.4336683004383 no 1447 0.429004635119913 1978 3278949
SGTC_2254 7938975 95.19 µM 0.177224034406702 0.434357976642956 no 1448 0.429666208871631 2084 2969277
SGTC_629 3448-6466 76.7 µM 0.176610183119674 0.434609304690205 no 1449 0.429907297426883 2013 573744
SGTC_232 clozapine 119 µM 0.176436961330758 0.434680231366455 no 1450 0.429975334583044 2010 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2822 7994718 71.43 µM 0.1753673005948 0.435118256707615 no 1451 0.430395516372108 2083 1018011
SGTC_2249 haloperidol 116.36 µM 0.173436786413418 0.435909002146496 no 1452 0.431154055923373 1996 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1214 0358-0031 63.7 µM 0.173009363124255 0.436084110999932 no 1453 0.431322033949556 2109 4301366
SGTC_264 promethazine 12.5 mM 0.172832288556947 0.436156659443013 no 1454 0.431391628174406 2133 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1238 0333-0287 48.8 µM 0.171978640019638 0.436506434130593 no 1455 0.431727160793008 2009 7226
SGTC_3263 9137018 49.47 µM 0.169835137141555 0.437384933120501 no 1456 0.432569896443869 1899 43844957
SGTC_16 erodoxin 22.806 µM 0.169164657919669 0.437659787733347 no 1457 0.432833564000446 2062 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2811 7967822 32.47 µM 0.168760969381682 0.437825289343147 no 1458 0.432992329914547 2041 2232244
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.168113914662506 0.438090587319978 no 1459 0.433246831414201 2070 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2807 7945238 51.95 µM 0.166873326977882 0.438599316619485 no 1460 0.433734860415753 2012 17148797
SGTC_1949 st076024 69.1 µM 0.166447026307509 0.438774153719255 no 1461 0.433902584210662 2050 2921930
SGTC_2974 9094440 9.66 µM 0.166246845578334 0.438856257217581 no 1462 0.433981347452824 2055 25236134
SGTC_2153 5569715 200 µM 0.165496207883156 0.439164152316087 no 1463 0.43427671717519 2076 2054701
SGTC_721 1187-1332 279 µM 0.164354966289565 0.439632335022833 no 1464 0.434725856551842 2046 25730
SGTC_2931 9014674 55.67 µM 0.163942872139997 0.439801413223602 no 1465 0.434888058291609 2042 2996810
SGTC_212 3807-4682 38.772 µM 0.161365547872705 0.440859112049072 no 1466 0.435902749924519 2092 3125501 YBL034C STU1
SGTC_175 3793-3120 23.7 µM 0.16016854322414 0.441350490457323 no 1467 0.436374154160412 2005 5322297
SGTC_1822 st052468 42 µM 0.159683830192914 0.441549494122837 no 1468 0.436565069540232 2044 2873678
SGTC_2197 6588183 93.1375 µM 0.159640154441538 0.441567426354282 no 1469 0.43658227296624 2047 884136
SGTC_1342 1486-1464 234 µM 0.157825571272569 0.442312556751757 no 1470 0.437297124112187 2006 3253938
SGTC_2367 9070478 135.38 µM 0.157731808033251 0.442351064738986 no 1471 0.43733406752222 2028 572802
SGTC_1108 betulinic acid 729.144 nM 0.156847407525767 0.44271430935247 no 1472 0.437682554703668 2005 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2909 7941780 10.49 µM 0.156570510041661 0.442828047739831 no 1473 0.437791672713873 2144 1243215
SGTC_1948 st076329 66.6 µM 0.156449016210618 0.442877954023456 no 1474 0.437839551728547 2135 24208413
SGTC_2264 7948757 110.76 µM 0.154706332083954 0.443593899501486 no 1475 0.43852641890987 1950 2971411
SGTC_2293 7624732 200 µM 0.153703118484203 0.444006132586996 no 1476 0.438921912904706 2074 894453
SGTC_2472 5377652 49.4 µM 0.153500623476921 0.44408934769582 no 1477 0.439001749335665 1982 1610903
SGTC_497 capsazepine 133 µM 0.152809094018294 0.444373549555609 no 1478 0.439274412988093 1946 2733484 A calcium channel blocker.
SGTC_3090 9117696 49.47 µM 0.152279132031315 0.444591370465105 no 1479 0.439483391594168 2128 7923821
SGTC_3025 9087895 49.47 µM 0.151384577956213 0.444959081146652 no 1480 0.439836177132485 2144 17173641
SGTC_2395 5646831 180.19 µM 0.150911541033856 0.445153544376072 no 1481 0.440022748164473 2071 6808628
SGTC_2728 chlorpromazine 9.18 µM 0.150772062153883 0.44521088600213 no 1482 0.44007776273304 2153 2726 A thorazine and dopamine antagonist.
SGTC_2764 methyldopa 94.69 µM 0.15045251002744 0.445342262458984 no 1483 0.440203807841035 2125 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1786 berberine 21.6 µM 0.149551687958236 0.445712646858352 no 1484 0.440559163404533 2146 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1389 3405-0187 19 µM 0.149489693785235 0.445738138293839 no 1485 0.440583620579924 1985 799890
SGTC_2320 7373003 200 µM 0.149402067406545 0.445774169839853 no 1486 0.440618190243081 2003 5415828
SGTC_189 3970-0742 2.116 µM 0.148656928152057 0.446080585589064 no 1487 0.44091217492635 2156 2891807
SGTC_2411 st077133 39.94 µM 0.148310800018978 0.446222931172218 no 1488 0.441048746218664 2156 1403142 YNL221C POP1
SGTC_2928 9011484 9.79 µM 0.148231736060809 0.446255447286778 no 1489 0.441079943358043 2026 2994751
SGTC_1115 galangin 695.678 nM 0.147696821425844 0.446475447597023 no 1490 0.441291020129823 2137 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_811 0416-0114 265 µM 0.147618048402295 0.446507846850745 no 1491 0.441322105295111 2018 6612453
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.147280458551845 0.446646701208601 no 1492 0.441455328042459 2181 688664
SGTC_1661 st013063 9.66 µM 0.146799042682732 0.446844724075695 no 1493 0.441645320163392 2091 721395
SGTC_832 4083-0019 164 µM 0.145921477317246 0.447205730892166 no 1494 0.441991688309566 2120 1990758
SGTC_1026 k007-1105 30.6 µM 0.144851043683942 0.447646137728944 no 1495 0.442414240069418 2039 7066794
SGTC_970 1315-0089 19.5 µM 0.142560096437224 0.448588914807346 no 1496 0.443318806967115 2141 6811083 YLR033W RSC58
SGTC_1901 st060216 58.6 µM 0.14253484201974 0.448599309204561 no 1497 0.443328780178795 2142 688792
SGTC_1520 flindersine 88 µM 0.142441593073795 0.448637689590993 no 1498 0.443365605392857 2149 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1016 4226-1401 38 µM 0.142340642772611 0.448679240324465 no 1499 0.443405472523038 2153 2901613
SGTC_668 1682-0499 62.6 µM 0.142136716711434 0.448763177178684 no 1500 0.44348600842137 2030 682214
SGTC_789 1309-1135 70.6 µM 0.142089559953475 0.448782587432097 no 1501 0.443504632228628 2160 3092424
SGTC_521 r062-0005 13.8 µM 0.142026135830967 0.448808693709535 no 1502 0.443529680768088 2019 2832033
SGTC_2518 prenyletin 46.28 µM 0.140675382247293 0.449364735682207 no 1503 0.444063196895412 2141 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_684 1140-0066 328 µM 0.140375806589001 0.449488070459087 no 1504 0.444181536055855 2044 6813534
SGTC_1675 st018485 24.5 µM 0.139313110166565 0.449925620005249 no 1505 0.444601365245098 2017 3323024
SGTC_248 streptozotocin 5.23457 mM 0.138491344923256 0.45026401146923 no 1506 0.444926054727544 2168 5300 DNA alkylating agent.
SGTC_3342 9147791 14.508 µM 0.138061171344492 0.450441165383489 no 1507 0.445096036310602 2140 1838168
SGTC_690 glyoxal 20.3 µM 0.137926553707102 0.450496605596258 no 1508 0.445149232073969 2088 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2135 5326629 150.42 µM 0.137836634206699 0.450533638103864 no 1509 0.445184765386215 2029 5020077
SGTC_1024 4507-0395 26 µM 0.13673801199021 0.450986130095449 no 1510 0.445618941244809 2042 4201836
SGTC_2961 9083290 32.55 µM 0.136609665376206 0.451038996669739 no 1511 0.445669668133708 2171 17741490
SGTC_69 0096-0274 206.684 µM 0.136045945911997 0.451271205642138 no 1512 0.445892479504444 2108 6741392
SGTC_3073 9114972 49.47 µM 0.135605051005088 0.451452831989015 no 1513 0.446066756108683 2195 41905075
SGTC_2145 5634607 200 µM 0.134993156038892 0.451704918522388 no 1514 0.446308642745064 2049 308662
SGTC_397 arbidol 50 µM 0.134854758858 0.45176193765499 no 1515 0.446363354955091 2151 131410 A RNA synthesis inhibitor.
SGTC_3195 9113082 49.47 µM 0.133909548714551 0.45215138732472 no 1516 0.446737049756554 2204 17018038
SGTC_1733 st037357 54.9 µM 0.132976929648149 0.45253569429428 no 1517 0.447105812959155 2116 1272339 YGL099W LSG1
SGTC_3199 9111318 49.47 µM 0.131198256054272 0.453268760324041 no 1518 0.447809237750693 2125 8548020
SGTC_2161 5662504 8.5105 µM 0.13118063377848 0.453276024004346 no 1519 0.447816207783302 2056 2859334
SGTC_1014 4130-3005 69.3 µM 0.131014280009783 0.45334459370421 no 1520 0.447882005481209 2011 743608
SGTC_1312 1218-2183 165 µM 0.130913686165589 0.453386058361434 no 1521 0.447921793934379 2189 6744073
SGTC_3225 9130819 49.47 µM 0.130503446227663 0.453555164010132 no 1522 0.448084063883051 2150 4547121
SGTC_910 3454-3003 490 µM 0.129603612204684 0.453926115457745 no 1523 0.448440022614346 2195 820824
SGTC_61 0978-8327 98.565 µM 0.128900190195597 0.454216125181839 no 1524 0.448718313085554 2189 6150059 YHR072W ERG7
SGTC_518 1021-0119 62.6 µM 0.12755839292702 0.454769394453216 no 1525 0.449249229850208 1992 1097762
SGTC_3014 9081533 49.47 µM 0.127485289473113 0.454799540057964 no 1526 0.449278157739908 2191 21367265
SGTC_2065 5221596 34.26 µM 0.127380256776028 0.454842852751312 no 1527 0.449319720875594 2107 788581
SGTC_1361 1608-0041 5.61 µM 0.127279067519543 0.454884581019649 no 1528 0.449359763625656 2094 X1361
SGTC_2794 7785382 27.27 µM 0.126463372735205 0.455220974109542 no 1529 0.449682570274135 2230 2205081
SGTC_725 1497-0963 19 µM 0.125643025976788 0.455559318062403 no 1530 0.450007251501351 2191 3549977
SGTC_745 0469-0705 296 µM 0.125283557529828 0.455707587459783 no 1531 0.45014953440385 2188 3486736
SGTC_537 1334-0398 209 µM 0.124829418438514 0.455894914329583 no 1532 0.450329298500181 2211 5846986
SGTC_1004 4084-0029 199 µM 0.124573995508898 0.456000277502402 no 1533 0.450430408287037 2189 716894 YLR208W SEC13
SGTC_2889 9059656 51.95 µM 0.123527871174876 0.456431840973215 no 1534 0.450844552646999 2129 3949838
SGTC_1356 1502-0781 85.8 µM 0.122970009380305 0.456661999836971 no 1535 0.451065423367469 2073 567702
SGTC_1771 st048882 4.1505 µM 0.122944179249855 0.456672657011096 no 1536 0.451075650496523 2006 4580403
SGTC_2714 st079313 56.9 µM 0.122597601673274 0.456815653399389 no 1537 0.451212876852514 2117 2939799
SGTC_3291 9121177 71.43 µM 0.122365356764385 0.456911479760733 no 1538 0.451304836794114 2088 17015612
SGTC_323 4013-0906 34.3 µM 0.120037643076342 0.457872053082364 no 1539 0.452226664335444 2211 2910086
SGTC_2114 5491910 81.25 µM 0.11822927307728 0.458618479969251 no 1540 0.452942998026653 2166 2849228
SGTC_818 4072-2707 53.5 µM 0.117559558736118 0.458894949944787 no 1541 0.453208325063578 2179 882871
SGTC_1052 3253-3998 198 µM 0.11713960872459 0.459068322920168 no 1542 0.453374711278372 2188 5450317
SGTC_1838 st055369 84.5 µM 0.11639505941469 0.459375723214855 no 1543 0.453669725398792 2206 676036
SGTC_580 1123-0028 41 µM 0.116134196314063 0.459483430895234 no 1544 0.453773093713732 2181 1677248 YPR107C YTH1
SGTC_912 3474-0017 2.18 µM 0.114685033084544 0.460081829358015 no 1545 0.454347388756828 2161 3360550
SGTC_2148 5546263 113.568 µM 0.113256629773203 0.460671743993276 no 1546 0.454913550182333 2098 792097
SGTC_517 1365-0151 113 µM 0.11257677682071 0.460952546164534 no 1547 0.455183048698724 2115 768657
SGTC_2545 solidagenone 89.61 µM 0.112065034334105 0.461163925902062 no 1548 0.455385920651552 2228 6708572 An anti ulcer agent
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.111550864832052 0.461376319190541 no 1549 0.455589766472563 2089 442882
SGTC_1397 3532-0190 20.1 µM 0.110045643056769 0.461998159754024 no 1550 0.456186588389516 2130 5322280
SGTC_2644 guaiazulene 100 µM 0.107281367146907 0.463140384435274 no 1551 0.457282883043307 2197 3515 A coloring agent.
SGTC_393 acivicin 6.25 µM 0.106684071756825 0.46338723273928 no 1552 0.457519809689325 2140 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2648 atorvastatin 78.68 µM 0.106127034130369 0.463617456151333 no 1553 0.457740781065331 2207 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2610 ononetin 44.17 µM 0.105668079344859 0.463807151125938 no 1554 0.457922853756716 2123 259632
SGTC_493 zm226600 134 µM 0.105479281491789 0.46388518735629 no 1555 0.457997754622265 2175 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2217 6934799 96.0675 µM 0.102882968247198 0.464958466847158 no 1556 0.45902792766571 2222 675606
SGTC_1414 3917-0015 5.4 µM 0.101674168239058 0.465458255291521 no 1557 0.459507653312583 2199 6618702
SGTC_1848 st056003 16.4 µM 0.10044443920155 0.465966752926655 no 1558 0.459995745375893 2261 146492
SGTC_2052 5265182 7.135 µM 0.0998688288158298 0.466204789153562 no 1559 0.460224231800031 2200 1239884
SGTC_2484 5809818 12.04 µM 0.0993333880062939 0.466426224627635 no 1560 0.46043678485237 2163 2870548
SGTC_2780 5215298 71.43 µM 0.0983158548419678 0.466847061517024 no 1561 0.460840744415582 2259 2834131
SGTC_3040 9091894 49.47 µM 0.0970239405566706 0.467381431784673 no 1562 0.461353691162677 2189 25236966
SGTC_2377 9073351 62.6 µM 0.0968007930190492 0.467473737549849 no 1563 0.461442297077819 2083 7337946 YHR072W ERG7
SGTC_1215 3852-0577 11.2 µM 0.0956876864342362 0.467934204035288 no 1564 0.461884310411814 2212 2884876
SGTC_1126 isoteolin 1.0172 µM 0.0954466109086068 0.468033937086129 no 1565 0.461980047444803 2226 133323
SGTC_1944 st076371 56.9 µM 0.0952793334123085 0.46810314103931 no 1566 0.462046478756384 2056 24208455
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.0947559058562416 0.468319693157568 no 1567 0.462254355623288 2263 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_143 4032-1194 15.74 µM 0.0935859207522116 0.468803772457168 no 1568 0.462719047068161 2173 1806963
SGTC_955 1216-0110 33 µM 0.0935494132284391 0.468818878127338 no 1569 0.462733547847314 2191 3619719
SGTC_1140 3229-1848 2.98 µM 0.0930867343022576 0.46901032406105 no 1570 0.462917328083654 2215 2849525
SGTC_2239 6685329 187.64 µM 0.0915872337723234 0.469630832024915 no 1571 0.463512997394909 2099 805680
SGTC_1759 st043059 70 µM 0.0914945192883196 0.469669200620684 no 1572 0.463549830473153 2165 669426
SGTC_1017 4239-0030 168 µM 0.0907001742964523 0.469997940720528 no 1573 0.463865416067575 2061 1149593
SGTC_360 0957-0399 1.01 µM 0.0901827493618304 0.47021208831967 no 1574 0.464070996239211 2235 6752301 YPR165W RHO1
SGTC_2286 7945697 125 µM 0.0901748716728654 0.470215348739875 no 1575 0.464074126229619 2159 1245733
SGTC_2625 euphol 100 µM 0.0899612354940816 0.470303769304449 no 1576 0.4641590097363 2265 6708538 A triterpene alcohol.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.0893353724382253 0.470562812328623 no 1577 0.464407691650784 2240 6312947
SGTC_959 1222-0044 107 µM 0.0877811465381449 0.471206155865722 no 1578 0.465025311397484 2274 6083612
SGTC_2100 5377183 190 µM 0.0867336571823674 0.471639787522801 no 1579 0.46544161132685 2206 2844202
SGTC_2537 larixol 68.93 µM 0.0863428538326182 0.47180157795339 no 1580 0.465596936609751 2215 6708759
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0861243759335557 0.471892028627801 no 1581 0.465683773211127 2128 688803
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.0846360125631937 0.472508255015897 no 1582 0.466275383943817 2222 641818 YHR062C RPP1
SGTC_2651 TUB2.036 5 µM 0.0843448769110568 0.472628801514902 no 1583 0.466391116440245 2253 15992207 YFL037W TUB2
SGTC_1669 st015249 58.4 µM 0.0842871186081167 0.47265271699218 no 1584 0.466414076908964 2280 722793
SGTC_504 lovastatin 124 µM 0.0840585230756502 0.472747370519062 no 1585 0.466504950837104 2090 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2140 5586273 200 µM 0.0835321011447992 0.47296534953076 no 1586 0.466714226777318 2263 854421
SGTC_2233 sulbentine 40.3845 µM 0.0827413648814097 0.473292790120564 no 1587 0.467028596600326 2226 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1094 duloxetine 25.4 µM 0.0812516884602269 0.473909707763009 no 1588 0.467620896958573 2254 60834 A selective serotonin reuptake inhibitor.
SGTC_3318 9139014 38.6185 µM 0.080056630904805 0.474404660605984 no 1589 0.468096107755063 2222 16643984
SGTC_3075 9116269 49.47 µM 0.0798023544349395 0.474509978532985 no 1590 0.468197225865242 2195 17015205 YNL244C SUI1
SGTC_1917 st066507 28.5 µM 0.079780796905526 0.47451890745655 no 1591 0.468205798741257 2160 3156428
SGTC_263 alizarin 107.927 µM 0.0793467758850957 0.474698677550322 no 1592 0.468378400890035 2271 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_485 niflumic acid 177 µM 0.0784426412216812 0.475073183685704 no 1593 0.468737977608876 2238 4488 A COX2 inhibitor.
SGTC_2280 7785178 200 µM 0.0778888270162346 0.475302592732852 no 1594 0.468958243579684 2212 2954328
SGTC_490 phenamil 164 µM 0.0757726384045092 0.476179266196546 no 1595 0.469799992458052 2258 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2689 tacrolimus 100 µM 0.0752076909060827 0.476413326676173 no 1596 0.470024732614539 2193 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_95 0471-0001 561.058 µM 0.0746856109864647 0.476629634147881 no 1597 0.470232428232792 2113 4015405
SGTC_3306 9127676 59.7925 µM 0.0740290128210883 0.476901684812658 no 1598 0.470493649849958 2170 41905287
SGTC_1798 st045719 60.953 µM 0.0726851450135522 0.477458527793749 no 1599 0.471028334920402 2279 3980186
SGTC_470 aa-861 153 µM 0.0726683571445125 0.477465484269741 no 1600 0.471035014646987 2176 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2940 9060638 45.86 µM 0.0714626113624708 0.477965133202495 no 1601 0.471514790129765 2178 4027022
SGTC_1050 3232-1156 69.3 µM 0.0706850034771323 0.478287384515301 no 1602 0.471824228236034 2193 700529
SGTC_1112 tnp00069 1.16933 µM 0.0705570386494173 0.478340416250978 no 1603 0.471875151671763 2261 145826
SGTC_1982 st072467 71.9 µM 0.0704316864950011 0.478392365603157 no 1604 0.471925035843373 2133 3163533
SGTC_2464 5717415 7.67 µM 0.0694473606981209 0.47880030975391 no 1605 0.472316765752421 2277 5285744
SGTC_976 1348-1067 47.6 µM 0.0681732467297579 0.479328386682445 no 1606 0.472823861714385 2294 5310671 YGL099W LSG1
SGTC_2118 5526350 200 µM 0.0672947281426206 0.479692523965237 no 1607 0.473173536854887 2226 743594
SGTC_1747 st037496 66.6 µM 0.0653299141623327 0.480506980854897 no 1608 0.473955662577308 2259 723305
SGTC_1694 st024011 44.9 µM 0.0651683904483151 0.48057393951192 no 1609 0.474019964189743 2291 2787533
SGTC_3126 9127922 49.47 µM 0.0608915347019416 0.482347077186588 no 1610 0.47572279563314 2228 45595682
SGTC_731 3966-0296 387 µM 0.060718234200701 0.482418933280204 no 1611 0.475791804840632 2290 660956
SGTC_1082 camptothecin 424.86 nM 0.0603316075752543 0.482579243463402 no 1612 0.475945764291664 2315 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_869 0564-0080 44.1 µM 0.0601037820570148 0.482673709955669 no 1613 0.47603648888261 2151 6843321
SGTC_2925 9010536 32.5 µM 0.0598606663445195 0.4827745175085 no 1614 0.476133303698941 2237 2994177
SGTC_2872 9044037 25.97 µM 0.0596231222963299 0.482873015843095 no 1615 0.476227901098779 2210 6465195
SGTC_787 4152-0075 138 µM 0.0593773446307339 0.482974929371481 no 1616 0.476325778790374 2170 9566539
SGTC_1693 xanthone 101.9 µM 0.0592718407811465 0.483018677665334 no 1617 0.476367794735997 2226 7020 An insecticide.
SGTC_1407 3909-7909 12.3 µM 0.0581084563860455 0.483501100824764 no 1618 0.476831119277464 2291 4411780
SGTC_2640 pentamidine 10.38 µM 0.0576658629731317 0.483684638387281 no 1619 0.477007392914199 2312 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1366 1683-0113 21.9 µM 0.0564550102239862 0.484186780362467 no 1620 0.477489667485046 2299 708623
SGTC_1717 st033143 58.0435 µM 0.0559160744050234 0.484410285756049 no 1621 0.477704332670357 2308 674616
SGTC_3076 9116187 49.47 µM 0.0556513502824569 0.484520072926042 no 1622 0.477809778123712 2294 27241210
SGTC_2117 5521686 200 µM 0.0553102763289424 0.484661525852276 no 1623 0.477945637686804 2262 803312
SGTC_1474 0330-0125 5.35 µM 0.0540912463469065 0.485167107399562 no 1624 0.47843123322098 2324 X1474
SGTC_529 4076-0302 30.3 µM 0.0533954011608855 0.485455713575538 no 1625 0.478708434664822 2162 5816522
SGTC_334 1502-1024 68.5 µM 0.0528771696175262 0.485670658332166 no 1626 0.47891488747425 2231 3296216
SGTC_2335 9018011 154.17 µM 0.0512993187363022 0.486325122398121 no 1627 0.479543505480591 2282 6458208
SGTC_421 streptovitacin 30 mM 0.0508887839324429 0.48649541093448 no 1628 0.479707071527944 2216 91467 include heat shock
SGTC_2765 myclobutanil 7.74 µM 0.0488760640189597 0.487330315826225 no 1629 0.480509032102231 2256 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2346 9031566 143.75 µM 0.0476350029603464 0.487845153542887 no 1630 0.481003567677139 2299 4771086
SGTC_1631 benzylvanillin 81.9 µM 0.0466203389406386 0.488266088540413 no 1631 0.481407910761754 2273 75506
SGTC_1578 josamycin 24.2 µM 0.0458311789341577 0.488593481896554 no 1632 0.481722403858934 2193 5282165 A P450 substrate.
SGTC_2762 leflunomide 42.06 µM 0.0447227107094576 0.489053357376046 no 1633 0.482164165639305 2296 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1412 3909-8563 178 µM 0.0445319157251957 0.489132514882897 no 1634 0.482240206066639 2323 23767530
SGTC_1149 3909-7961 23.3 µM 0.0444939730573778 0.489148256684256 no 1635 0.48225532801231 2190 735261
SGTC_3155 9099265 49.47 µM 0.0438266707970964 0.489425112378046 no 1636 0.482521283641782 2295 25236499
SGTC_3237 9133362 49.47 µM 0.0433742388692312 0.489612823858011 no 1637 0.482701606387053 2328 43845137
SGTC_723 4182-0001 115 µM 0.0432906107647116 0.489647520944672 no 1638 0.482734937865829 2263 744821 YLR208W SEC13
SGTC_1266 0828-0227 32.9 µM 0.0426037470225849 0.489932501894761 no 1639 0.483008704256004 2298 3913820
SGTC_726 3448-4391 34.2 µM 0.0414617733064244 0.490406320062037 no 1640 0.483463883557441 2300 1356692
SGTC_2212 7123476 200 µM 0.0413388026755161 0.490457342825287 no 1641 0.48351289971687 2316 1085715
SGTC_1730 st033808 45.1 µM 0.0399147994351404 0.491048198966646 no 1642 0.484080526131426 2147 1045166
SGTC_3307 9126885 69.2785 µM 0.0375458478645909 0.492031181739045 no 1643 0.485024892294252 2318 24824909
SGTC_269 exalamide 29 µM 0.0367895757917781 0.492345002944095 no 1644 0.485326392868169 2257 3316 A derivative of salicylamide.
SGTC_305 1682-2595 20.8 µM 0.0359623513160411 0.492688271840585 no 1645 0.48565618941017 2292 226033
SGTC_2942 9052777 62.25 µM 0.034921434334279 0.493120223230622 no 1646 0.48607119445431 2330 6469503
SGTC_1984 st072354 53.1 µM 0.0344791460949548 0.493303762932375 no 1647 0.486247535732538 2280 5762938
SGTC_546 peri-Naphthalide 147 µM 0.0342954934099757 0.493379975097294 no 1648 0.486320759247626 2312 223824 A penicillin ester.
SGTC_3083 9117465 49.47 µM 0.0341830285290273 0.493426645876962 no 1649 0.486365599951984 2195 16420915
SGTC_1498 4478-3555 97.6 µM 0.0315389797443258 0.494523900215062 no 1650 0.4874198531277 2348 3437919
SGTC_928 2764-0428 58.7 µM 0.0307261320159474 0.49486123276935 no 1651 0.487743975331633 2268 662578
SGTC_2712 st079126 47.7 µM 0.0303627946602556 0.495012019308603 no 1652 0.487888858362961 2340 3152970
SGTC_1953 st076800 12.1 µM 0.0302467581270015 0.495060175111819 no 1653 0.487935128990246 2223 297591
SGTC_1676 st018489 23.4 µM 0.0300038899181816 0.495160966994206 no 1654 0.488031975431325 2238 3696235
SGTC_1192 1488-0095 21.4 µM 0.02954066879706 0.495353207615918 no 1655 0.488216692036572 2299 915875
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0291168879071811 0.495529081159624 no 1656 0.48838568345299 2324 521171
SGTC_681 1642-0006 26.6 µM 0.0286945440577233 0.495704359180999 no 1657 0.488554103894413 2352 4446530
SGTC_229 benomyl 22.8748 µM 0.026608054124156 0.496570290320711 no 1658 0.489386174636568 2313 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_52 0329-0193 875 nM 0.0262684722708762 0.496711224581464 no 1659 0.489521600856347 2334 3739292
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.0261344128471714 0.496766862432251 no 1660 0.489575064473556 2350 688751
SGTC_1563 conessine 56.1 µM 0.0257656329762914 0.496919915174982 no 1661 0.489722136827507 2355 441082 An anti-amoebic, histamine inhibitor.
SGTC_1623 st003709 20.3 µM 0.0253461722424684 0.497094002275771 no 1662 0.489889422811465 2354 16192618
SGTC_1123 mangostin 811.285 nM 0.0242110846780963 0.497565095781301 no 1663 0.490342118214164 2280 5281650 An antioxidant.
SGTC_1256 0570-0116 285 µM 0.0240759653606054 0.497621174366091 no 1664 0.490396007314237 2346 410638
SGTC_2993 9054257 71.4286 µM 0.0235283228705888 0.497848462957088 no 1665 0.49061442317567 2377 6470217 YGL055W OLE1
SGTC_454 lyso-paf C-16 6.67 µM 0.0231431463712373 0.49800832355394 no 1666 0.490768044532279 2336 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_682 0kpi-0099 17 µM 0.023135623834829 0.498011445651006 no 1667 0.490771044786786 2336 1714895 YML126C ERG13
SGTC_548 1436-0017 110 µM 0.0216175572091196 0.498641494862992 no 1668 0.491376514088335 2370 9677137
SGTC_2244 6635614 200 µM 0.0215812225828599 0.498656575014809 no 1669 0.491391006126086 2347 836499
SGTC_2751 anetholtrithion 17.25 µM 0.0203093099557679 0.499184464685134 no 1670 0.491898314524458 2357 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2261 9010538 184.68 µM 0.0200726039101646 0.499282706427035 no 1671 0.491992727327036 2271 6457250
SGTC_2870 9038528 12.99 µM 0.019656632053273 0.499455350196154 no 1672 0.492158643348298 2291 6463316
SGTC_777 1315-0167 517 µM 0.0191991147490902 0.499645236985374 no 1673 0.492341131900664 2275 4221767
SGTC_2737 bleomycin 30.5 nM 0.0183443415682967 0.5 no 1674 0.492682076976232 2366 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2166 5933061 31.504 µM 0.0182930111604283 0.499978695947606 no 1675 0.492702551410568 2362 2877375
SGTC_2893 9048488 25.97 µM 0.0176104065829075 0.499695389370159 no 1676 0.492974827356169 2359 6467338
SGTC_2425 5628681 7.85 µM 0.0172073591748795 0.499528109597224 no 1677 0.493135595643345 2353 5714958
SGTC_103 0844-0104 51.839 µM 0.0156383219017239 0.498876901411273 no 1678 0.493761466479534 2374 5375804
SGTC_1899 st063254 59.6 µM 0.0147145644459343 0.498493509374674 no 1679 0.494129949934571 2383 3093813
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0139282735993803 0.498167171928289 no 1680 0.494443602422686 2380 229346 A bile salt which induces apoptosis.
SGTC_654 1124-0271 80.9 µM 0.013662486686526 0.498056861585373 no 1681 0.494549625970205 2368 5403748
SGTC_761 k216-0224 480 µM 0.0126971875954689 0.497656231908254 no 1682 0.494934691129989 2387 1340404
SGTC_794 k038-0031 316 µM 0.0118657879667154 0.497311176625906 no 1683 0.4952663465707 2384 6624242
SGTC_1846 st056244 14.8 µM 0.0116182412320142 0.497208437832093 no 1684 0.495365096621484 2338 5393182
SGTC_827 3253-0474 693 µM 0.0114836771934254 0.497152590083136 no 1685 0.49541877632464 2389 5402065
SGTC_540 1187-0821 17.3 µM 0.0104513119077523 0.4967241322483 no 1686 0.495830605698241 2381 847520
SGTC_1138 3761-0006 1.03 µM 0.0103918133169016 0.496699438931158 no 1687 0.495854340912789 2373 12061087
SGTC_1515 3460-0031 42.1 µM 0.00961250622964181 0.496376009330252 no 1688 0.496165223900193 2374 2876596
SGTC_2753 fluvastatin 17.09 µM 0.00952610079025403 0.496340149313145 no 1689 0.496199693104975 2372 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1765 st044815 90.4 µM 0.0085331941198273 0.495928075018204 no 1690 0.496595789391939 2372 645695
SGTC_3051 9093778 49.47 µM 0.00734281340056839 0.495434051172898 no 1691 0.497070667600863 2392 17217378
SGTC_697 0508-1955 564 µM 0.00716427743437069 0.495359956955539 no 1692 0.497141891272554 2391 6243113
SGTC_1789 tunicamycin 25 nM 0.00690623110311639 0.495252865422437 no 1693 0.497244834316504 2385 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1744 st037937 38.9 µM 0.00681699291421392 0.495215830855923 no 1694 0.497280434365006 2384 1016152
SGTC_1056 3448-1962 115 µM 0.00608441737257025 0.49491180769854 no 1695 0.497572683635078 2390 715507
SGTC_3141 9094609 49.47 µM 0.0059601983992795 0.494860256382402 no 1696 0.497622238936872 2395 25236309 YDL196W YDL196W
SGTC_1130 3454-2858 15.9 µM 0.00594415344442253 0.494853597675257 no 1697 0.497628639834363 2371 715628 YIL048W NEO1
SGTC_78 0336-0123 156.75 µM 0.00592168522998248 0.494844273297427 no 1698 0.497637603197314 2392 6765896
SGTC_2875 9039966 71.43 µM 0.00482249125741964 0.494388107970248 no 1699 0.498076111797678 2379 6463691
SGTC_3353 9151644 39.2805 µM 0.00370319859798458 0.493923609235487 no 1700 0.498522640883213 2393 4909158
SGTC_764 1951-2361 146 µM 0.00351392758803781 0.493845063868736 no 1701 0.4985981485998 2401 5438930
SGTC_1221 2958-7315 257 µM 0.00349669344800301 0.493837911903862 no 1702 0.498605023984687 2394 4562705
SGTC_1979 st071809 45.3 µM 0.00290205219519 0.493591144025407 no 1703 0.498842250304484 2393 4976333
SGTC_2905 7799065 20.05 µM 0.00279150321143782 0.493545267996837 no 1704 0.498886352789429 2402 1296806
SGTC_1044 1222-0021 1.78 µM 0.00155364184236382 0.493031581651182 no 1705 0.499380186829831 2394 4306703
SGTC_612 0302-0167 22.4 µM 0.00142257519401902 0.492977192419681 no 1706 0.499432474799474 2398 235821
SGTC_2409 alverine citrate 63.97 µM 0.000951158164639216 0.492781567767182 no 1707 0.499620542849992 2400 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_208 k072-0098 12.366 µM 0 0.492386869528731 no 1708 0.5 2403 5948901
SGTC_516 3992-2719 87.3 µM -0.00157134293700132 0.491734832247589 no 1709 0.499373125123391 2407 5350887 YDR037W KRS1
SGTC_1168 k815-0004 80.5 µM -0.00190074962077443 0.491598145898007 no 1710 0.499241711068413 2408 642433
SGTC_2750 bromebric acid 70.15 µM -0.0023086240845843 0.491428900939165 no 1711 0.499078993061228 2414 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1991 st073000 8.92 µM -0.00260235263359365 0.491307021068025 no 1712 0.498961812677754 2415 4301969 YIL048W NEO1
SGTC_961 1252-1571 372 µM -0.0027677892572081 0.491238375069184 no 1713 0.498895813251858 2410 6813498
SGTC_107 0358-0022 2.6945 µM -0.00312527619725382 0.491090040918744 no 1714 0.498753197216644 2425 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1281 0884-0031 11.8 µM -0.00433688490887396 0.490587310304222 no 1715 0.498269838668261 2414 1548255
SGTC_1754 st042065 16.137 µM -0.00464469561756136 0.490459593313036 no 1716 0.498147041200936 2420 1126236 YIL048W NEO1
SGTC_913 3487-1245 167 µM -0.00476165836726778 0.490411063319342 no 1717 0.498100380330942 2417 4016153
SGTC_1454 4239-0054 42.6 µM -0.00490077112761641 0.49035334306417 no 1718 0.498044883016815 2418 1340767
SGTC_2955 9076254 12.21 µM -0.00667745382068107 0.489616185317124 no 1719 0.49733610114201 2414 16459619
SGTC_346 4513-0042 7.16 µM -0.0087260924483108 0.48876623538718 no 1720 0.496518836958413 2418 2827372
SGTC_3252 9135871 49.47 µM -0.00938824689110272 0.488491528004906 no 1721 0.496254686394517 2433 17682838
SGTC_1995 st072814 61.1 µM -0.0109595534580883 0.487839663636866 no 1722 0.495627858275735 2433 5769371
SGTC_1204 4049-0315 18.3 µM -0.011106584303845 0.487778668792196 no 1723 0.49556920502489 2464 588402
SGTC_3266 9136860 49.47 µM -0.0131640750895136 0.486925161994331 no 1724 0.494748445541012 2421 4871271 YPR165W RHO1
SGTC_753 1322-0200 289 µM -0.0137303003747206 0.486690285680693 no 1725 0.494522574760202 2459 5403907
SGTC_1074 carmofur 3.8 µM -0.0140172622901919 0.486571252561937 no 1726 0.494408104536897 2418 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1945 st075991 56.6 µM -0.0143667732685515 0.486426275422023 no 1727 0.494268683872174 2450 1084980
SGTC_2465 5809242 33.21 µM -0.0149515599047038 0.486183709970023 no 1728 0.494035412826613 2440 2731748
SGTC_1241 0364-0022 50.8 µM -0.0151996805829719 0.486080792768155 no 1729 0.493936438245493 2450 4563895
SGTC_1856 st057054 55.7 µM -0.0160864493010359 0.485712980364336 no 1730 0.493582712004531 2442 1266018
SGTC_2823 7987624 58.44 µM -0.0166715515119102 0.485470299311675 no 1731 0.49334932130574 2446 2239440
SGTC_828 2074-0507 139 µM -0.0198262790703317 0.484161917612096 no 1732 0.492090977167419 2474 X828
SGTC_1179 1021-1431 9.29 µM -0.0201134625061283 0.484042820320821 no 1733 0.491976430395702 2457 2840958
SGTC_1784 st039334 36.3 µM -0.0207548987592151 0.483776816680522 no 1734 0.491720587778401 2454 3496984
SGTC_2430 5571206 200 µM -0.0207821428921739 0.483765518696488 no 1735 0.491709721285654 2452 1731771
SGTC_1267 0828-0272 9.49 µM -0.0225097010019671 0.483049137364566 no 1736 0.491020686840525 2448 745334
SGTC_1111 tnp00062 510.699 nM -0.0227548180430518 0.482947496959064 no 1737 0.490922924330556 2447 676306
SGTC_1916 st067606 49.2 µM -0.0229609107906938 0.482862039252002 no 1738 0.490840726696179 2473 19590279
SGTC_2536 dehydroabietamide 32.04 µM -0.0246324657522581 0.482168947477713 no 1739 0.490174061612656 2467 3983547
SGTC_1625 st003711 30.1 µM -0.0250881279981456 0.481980021426851 no 1740 0.489992334844132 2470 24207034 YER133W GLC7
SGTC_1727 st034309 9.9045 µM -0.0254036185502055 0.481849215538365 no 1741 0.489866512427477 2468 870305
SGTC_218 alverine citrate 93.75 µM -0.0255966842796862 0.481769169304509 no 1742 0.489789515383241 2479 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2546 rhodinyl acetate 100 µM -0.0256816668634401 0.481733935237585 no 1743 0.489755623379073 2454 6708682
SGTC_1452 4194-0072 190 µM -0.0258621075974294 0.481659124371835 no 1744 0.489683661843317 2451 1343545
SGTC_2322 7413319 38.22 µM -0.0266349223680993 0.481338722118586 no 1745 0.48937545955564 2492 1840400
SGTC_528 3492-0019 172 µM -0.0268336438086559 0.481256335885214 no 1746 0.489296209497047 2451 2869262
SGTC_899 1083-0020 478 µM -0.0292795400110148 0.480242379210878 no 1747 0.488320822305961 2477 767123
SGTC_408 cantharidin 100 µM -0.0293013400101047 0.480233342493515 no 1748 0.488312129094495 2493 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2223 6903751 107.57 µM -0.0306821587141274 0.479660974909579 no 1749 0.487761509873691 2487 5598863
SGTC_2059 5238311 157 µM -0.031527331153803 0.479310660388621 no 1750 0.487424497933135 2469 703021
SGTC_10 0279-0212 42.575 µM -0.0321812087766598 0.479039646379799 no 1751 0.487163770820559 2464 39851 YBR002C RER2
SGTC_2895 9054447 58.44 µM -0.0325003752163384 0.478907364318047 no 1752 0.487036508404818 2462 2697450
SGTC_1626 st003712 1.76 µM -0.0326109666750203 0.478861529005818 no 1753 0.48699241217049 2491 24207035
SGTC_1286 0929-0070 131 µM -0.0329446293148886 0.478723242163075 no 1754 0.486859371524246 2510 1420408
SGTC_930 2810-3379 265 µM -0.0339887794301747 0.47829050964124 no 1755 0.486443049125137 2461 1015764
SGTC_625 k213-0058 121 µM -0.034886301207306 0.477918565492814 no 1756 0.48608520200894 2502 3655420
SGTC_813 k007-0158 173 µM -0.0352806054240358 0.47775516699981 no 1757 0.485927994165876 2515 6523916
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0359360556847422 0.477483558651669 no 1758 0.48566667307284 2510 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3112 9123419 49.47 µM -0.0393616923596444 0.476064201385257 no 1759 0.484301010646975 2479 17015854
SGTC_2144 5628481 200 µM -0.0394801435525027 0.476015128373091 no 1760 0.484253792161235 2460 2818399
SGTC_643 k048-0106 28.4 µM -0.0398669739859391 0.475854871363434 no 1761 0.484099590550712 2546 6763920
SGTC_359 0081-0058 15.9 µM -0.0407964589010854 0.475469818212308 no 1762 0.483729081198998 2532 3494159
SGTC_1480 1070-0044 41.2 µM -0.0417492925081279 0.475075116295048 no 1763 0.483349279226003 2563 3124987
SGTC_1019 4262-0212 3.4 µM -0.0427307784816247 0.474668570996166 no 1764 0.482958072144828 2485 4677213
SGTC_2984 9022109 38.96 µM -0.0428264637436027 0.47462893821866 no 1765 0.482919934160653 2470 6459207
SGTC_1451 4152-0210 104 µM -0.042992854990106 0.474560019663367 no 1766 0.48285361474047 2462 659563
SGTC_2549 cedrol 20.94 µM -0.0431509677563215 0.474494530725205 no 1767 0.482790595356592 2502 6708665 A sedative which affects the nervous system.
SGTC_1249 0481-0015 10.2 µM -0.0436440050211764 0.474290323394026 no 1768 0.482594087081098 2485 4227577
SGTC_1832 st054113 55 µM -0.0438002360593354 0.474225616662856 no 1769 0.482531819459115 2483 1251267
SGTC_552 k242-0005 476 µM -0.0447761004459384 0.473821455103999 no 1770 0.482142887531559 2538 4088318
SGTC_2544 sphondin 68.51 µM -0.0453974816210165 0.473564119441441 no 1771 0.481895244147571 2498 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2514 salinomycin 42.74 µM -0.0454804544712751 0.473529758316667 no 1772 0.481862176924059 2531 23682228 A polyether potassium ionophore.
SGTC_2369 9071472 200 µM -0.0455773353572919 0.47348963777698 no 1773 0.481823567080016 2564 17296037
SGTC_3344 9148862 3.898 µM -0.0459990749756735 0.473314989115834 no 1774 0.481655493596596 2528 4905352
SGTC_2612 dictamnine 15.46 µM -0.0464336302682347 0.473135038658895 no 1775 0.481482316166652 2533 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2584 androsterone 48.74 µM -0.0474151983061392 0.472728589060882 no 1776 0.481091158073704 2487 2754130 A steroid.
SGTC_1210 3013-0140 750 nM -0.047793742365815 0.472571848365526 no 1777 0.48094031186383 2519 905973
SGTC_2009 4012297 12.05 µM -0.0480765152726675 0.472454765631403 no 1778 0.480827631327653 2533 45595307
SGTC_1160 4092-0570 10.5 µM -0.0486789559301685 0.472205331722642 no 1779 0.480587573362465 2498 4994975
SGTC_2232 chlorophetanol 41.5365 µM -0.0488841992738083 0.472120355464728 no 1780 0.480505790479975 2508 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3132 9126706 49.47 µM -0.0491321048654451 0.472017717582543 no 1781 0.480407009155875 2622 850858
SGTC_2238 6671620 73.2395 µM -0.0501398818798829 0.471600496908395 no 1782 0.480005459272986 2482 729941
SGTC_3270 9137563 49.47 µM -0.0502914476846052 0.471537751201106 no 1783 0.479945069453173 2631 17015724
SGTC_1271 0832-2808 169 µM -0.051833034391046 0.470899600501328 no 1784 0.479330866641581 2525 3663794
SGTC_858 0438-0351 2.77 µM -0.0523240790093146 0.470696344727555 no 1785 0.479135233659263 2520 2799119
SGTC_1760 st045453 10.4495 µM -0.0528052318945863 0.470497190796241 no 1786 0.478943546434871 2477 3323419 YIL048W NEO1
SGTC_774 k060-0086 136 µM -0.0536377284168642 0.470152629720432 no 1787 0.478611898416986 2496 5911235
SGTC_2687 chenodiol 100 µM -0.0537743031847875 0.470096105065912 no 1788 0.478557491488209 2526 5702181 A cholesterol synthesis inhibitor.
SGTC_333 3486-0131 40.1 µM -0.0538286967816872 0.470073593174342 no 1789 0.478535822966198 2612 6744690
SGTC_125 0133-0007 11.75 µM -0.0539527215519647 0.470022263369418 no 1790 0.478486416037676 2562 26541
SGTC_1510 1123-0200 71.5 µM -0.0541250852358544 0.469950928493055 no 1791 0.478417753204586 2534 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2222 6885208 172.143 µM -0.0543212861987157 0.469869729433072 no 1792 0.478339595327758 2511 609514
SGTC_67 0335-0847 266 µM -0.0547017930713734 0.469712257733355 no 1793 0.478188020419589 2706 4552207 YOR254C SEC63
SGTC_116 0155-0182 31.788 µM -0.0551864264125388 0.469511700449482 no 1794 0.477994971304883 2516 771486
SGTC_2044 5102272 200 µM -0.0553589295384958 0.469440314822258 no 1795 0.477926257557348 2555 592666
SGTC_3299 9121982 43.1275 µM -0.0554403555994411 0.46940661924976 no 1796 0.477893823069802 2537 17594604 YPL160W CDC60
SGTC_183 3914-0051 30.55 µM -0.055834309891072 0.469243596957924 no 1797 0.477736901112355 2535 1596232
SGTC_1307 1187-1599 12.2 µM -0.0563810337991428 0.469017365594122 no 1798 0.477519132877255 2521 1538471
SGTC_2206 7254556 146.969 µM -0.0570462980533881 0.468742096381829 no 1799 0.47725415732529 2496 4398905
SGTC_1216 1165-0504 9.65 µM -0.0574969904858023 0.468555619944658 no 1800 0.477074651694533 2515 6304004
SGTC_1478 0453-0656 35.7 µM -0.0601340863674393 0.467464646821678 no 1801 0.47602442103994 2519 5258496
SGTC_1986 st071812 45 µM -0.0602721373241145 0.467407541457078 no 1802 0.475969446392301 2524 11838594
SGTC_2258 7960471 200 µM -0.0605527748092988 0.467291456638373 no 1803 0.475857692352941 2566 2974708
SGTC_438 sphingosine 6.67 µM -0.0605877197367889 0.467277001972889 no 1804 0.475843776893511 2531 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.060763823020796 0.467204159037366 no 1805 0.475773651052644 2538 1273210
SGTC_2481 5478948 45.16 µM -0.0611489245747466 0.467044870394434 no 1806 0.475620302922532 2596 77792
SGTC_1066 ketoconazole 628 nM -0.0624364263921592 0.466512362531132 no 1807 0.475107643733905 2560 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0648778785722972 0.465502748761619 no 1808 0.474135616910714 2503 279621
SGTC_1370 2001-0092 44.6 µM -0.0650186488556515 0.465444542730635 no 1809 0.47407957601565 2548 790957
SGTC_2711 st079103 59.1 µM -0.0656759585600043 0.465172766558708 no 1810 0.473817906684202 2586 54693780
SGTC_2210 7115885 190.385 µM -0.0657212502840739 0.465154040501518 no 1811 0.473799876853676 2530 2927039
SGTC_2946 9065502 71.43 µM -0.0658202307151541 0.465113116887251 no 1812 0.473760474689782 2510 16489101
SGTC_435 c-PAF 6.7 µM -0.0664483886065041 0.464853412642327 no 1813 0.473510423381187 2525 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1748 st037455 53.6035 µM -0.0665797217872442 0.464799116423686 no 1814 0.473458144793967 2588 580690
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0670941969077938 0.464586426658866 no 1815 0.473253356841868 2520 23665772 A membrane-active detergent.
SGTC_48 0382-0018 55 µM -0.0671407166312655 0.464567195383179 no 1816 0.473234839911408 2526 762596
SGTC_2021 4019055 173 µM -0.0675625510936877 0.464392812600715 no 1817 0.473066933574411 2598 44827708 YER133W GLC7
SGTC_2098 5376439 882.5 nM -0.0690565543633638 0.463775259577249 no 1818 0.47247230151248 2613 2844116
SGTC_3104 9120930 49.47 µM -0.0702912074582489 0.463264975920225 no 1819 0.471980940315118 2589 17014836
SGTC_3117 9124945 49.47 µM -0.0708525506319578 0.463032992024572 no 1820 0.471757553761521 2512 17592065
SGTC_815 1582-0027 36.9 µM -0.0716728898351363 0.462693996577455 no 1821 0.471431115718919 2591 3128206
SGTC_38 0929-0051 58.268 µM -0.0718972646266109 0.462601281063981 no 1822 0.471341833464812 2587 1379719
SGTC_1113 artemisinin 1.17947 µM -0.0736543870576017 0.461875278581282 no 1823 0.470642697004049 2531 2240 An anti-malaria and mitochondrial poison.
SGTC_2095 5432005 200 µM -0.0744013914038409 0.461566671941583 no 1824 0.470345500846817 2562 783734
SGTC_2203 7227154 166.4 µM -0.0746105237601105 0.461480278143581 no 1825 0.470262300357316 2548 896304
SGTC_1969 st069479 40.1 µM -0.0748631028719833 0.461375938660804 no 1826 0.470161816892727 2590 3895485
SGTC_3064 1327-0027 10 µM -0.0748721654391862 0.461372194997682 no 1827 0.470158211569884 2546 16000455 YPR107C YTH1
SGTC_2342 7990637 118.86 µM -0.0751751769967731 0.461247025683992 no 1828 0.470037667171546 2602 2033102 YER133W GLC7
SGTC_1466 k213-0079 57.5 µM -0.0756463142955823 0.461052413897473 no 1829 0.469850244259754 2527 3657981
SGTC_3197 9113331 49.47 µM -0.0773132642610104 0.460363925245729 no 1830 0.469187169568609 2612 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2727 riluzole 51.77 µM -0.0779742992453196 0.460090935387904 no 1831 0.468924248482308 2548 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_708 3448-5400 146 µM -0.0785626611613808 0.459847973392379 no 1832 0.468690243890794 2547 3462195
SGTC_962 1254-0300 21.5 µM -0.0806516089005333 0.45898547145981 no 1833 0.467859510941761 2533 7340576
SGTC_2079 5212404 121 µM -0.0816534921418351 0.458571873903218 no 1834 0.467461131347081 2556 758462
SGTC_279 1273-0055 2.93 µM -0.0826229574499805 0.458171701809201 no 1835 0.467075673140067 2563 2847562
SGTC_3337 9144342 33.5465 µM -0.0826931344199884 0.458142736074879 no 1836 0.467047772057634 2639 17682949
SGTC_74 000s-0487 160.283 µM -0.0836817775147233 0.457734694656524 no 1837 0.466654722878597 2544 677548
SGTC_3288 9119690 36.221 µM -0.0842900654736514 0.457483658841404 no 1838 0.466412905448467 2587 17595618 YKL019W RAM2
SGTC_1721 st082152 9.2685 µM -0.0846885403673954 0.457319220471764 no 1839 0.466254503349013 2559 5296051
SGTC_2564 betulinic acid 100 µM -0.0853748999353972 0.457035998072666 no 1840 0.465981673621295 2587 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2137 5261020 140 µM -0.0864862780315061 0.456577440514374 no 1841 0.465539931871464 2562 763655
SGTC_1349 flufenamic acid 69 µM -0.0867832789948574 0.456454906892216 no 1842 0.465421889451258 2555 3371 A non-steroidal anti-inflammatory.
SGTC_21 0849-0113 22.993 µM -0.087320196668881 0.45623340140242 no 1843 0.465208500358064 2561 1560156
SGTC_2700 st077718 96.8 µM -0.0882118599043563 0.455865575644698 no 1844 0.464854145612082 2617 904970
SGTC_1579 chlormadinone acetate 49.4 µM -0.0899537029849083 0.455147146107358 no 1845 0.464162002638354 2648 45114258 A steroidal progestin.
SGTC_1893 st059353 36.1 µM -0.0907376606681281 0.454823847619171 no 1846 0.463850522581358 2622 3112488
SGTC_1436 4092-1007 8.32 µM -0.0911373604734803 0.454659025808751 no 1847 0.463691723395254 2581 2881121
SGTC_254 nsc-64875 3.808 µM -0.0916821609852379 0.454434382267351 no 1848 0.463475285580473 2718 56993
SGTC_383 2324-0395 7.37 µM -0.0927412714984314 0.453997709438398 no 1849 0.46305455418419 2674 3146421
SGTC_1484 3473-2379 286 µM -0.0932078099386642 0.453805372559984 no 1850 0.462869234984235 2557 671917
SGTC_3170 9103054 49.47 µM -0.0933917484064953 0.453729544375953 no 1851 0.462796172843008 2632 16432970
SGTC_113 0099-0221 2.5 µM -0.0936247001836747 0.453633512996028 no 1852 0.462703643942115 2561 89219
SGTC_1493 4348-0038 111 µM -0.0942232876436553 0.453386765445542 no 1853 0.462465893100826 2580 800424
SGTC_3173 9105693 49.47 µM -0.0955642281907225 0.452834073247103 no 1854 0.46193333844763 2671 17096658
SGTC_646 4092-0839 27.3 µM -0.0956021720219074 0.45281843535484 no 1855 0.46191827004015 2658 877796
SGTC_850 0388-0143 75.9 µM -0.0967275163297312 0.452354677579259 no 1856 0.461471393707722 2591 67273
SGTC_135 0933-0004 26.348 µM -0.098097900658243 0.451790025897699 no 1857 0.460927277259792 2660 21230617 YGL099W LSG1
SGTC_600 1495-0418 41.6 µM -0.0982914654789691 0.45171027749085 no 1858 0.460850427463861 2591 5377768
SGTC_2603 homopterocarpin 100 µM -0.0986674208397456 0.451555390034285 no 1859 0.46070116850511 2663 101795 A weak amylase inhibitor.
SGTC_2278 7948257 134.34 µM -0.0987817180360976 0.451508302920427 no 1860 0.460655792191711 2574 1247028
SGTC_3068 9116768 49.47 µM -0.0989625274854881 0.45143381609028 no 1861 0.460584011370377 2652 41904888
SGTC_2679 rapamycin 1 nM -0.0999741185141173 0.451017109482811 no 1862 0.460182436458018 2617 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_716 1683-5115 658 µM -0.100057950323632 0.450982578902532 no 1863 0.460149159261044 2573 723597
SGTC_1463 k081-0032 34.1 µM -0.100293783882909 0.450885440324333 no 1864 0.460055546176932 2596 977755
SGTC_898 1000-0849 28.3 µM -0.100340831049578 0.450866062200468 no 1865 0.460036871277791 2546 6751807
SGTC_2674 ligustilide 100 µM -0.100726920047243 0.450707041527814 no 1866 0.459883620471302 2660 5319022 A signalling regulator.
SGTC_933 2914-0560 114 µM -0.101143094174875 0.450535638383129 no 1867 0.459718434610255 2601 463887
SGTC_3264 9137442 49.47 µM -0.101260755235128 0.450487180829355 no 1868 0.459671734399762 2651 17015726
SGTC_196 k015-0023 18.111 µM -0.102166640773434 0.45011412552395 no 1869 0.459312202985904 2586 5211998
SGTC_1903 st060211 78.3 µM -0.102610685099504 0.449931278441893 no 1870 0.459135981062272 2615 688960
SGTC_325 2810-4341 181 µM -0.103139529039174 0.449713526729973 no 1871 0.458926116330303 2660 774970
SGTC_3079 9117512 49.47 µM -0.10333689627362 0.449632264565422 no 1872 0.458847796680366 2559 7185044
SGTC_2251 lansoprazole 556 µM -0.104209546764893 0.449272992863305 no 1873 0.45850152900067 2603 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1770 st043884 66.3 µM -0.104842514471843 0.449012424977303 no 1874 0.458250387127874 2593 670149
SGTC_3298 9116858 71.43 µM -0.105319883854613 0.448815925334879 no 1875 0.458060992842742 2702 2506942
SGTC_2917 7979103 53.79 µM -0.106817921292018 0.448199369659082 no 1876 0.45746671484256 2694 2980565
SGTC_1446 4239-0190 62 µM -0.107918768369558 0.447746367513619 no 1877 0.457030064532446 2610 1340085
SGTC_1061 3448-9325 110 µM -0.108337105023883 0.447574238459007 no 1878 0.456864145131208 2569 723482
SGTC_1907 st060210 83.7 µM -0.109358614812398 0.447153968970918 no 1879 0.456459028707302 2688 688793
SGTC_3158 9100007 49.47 µM -0.111062900635038 0.446452924117894 no 1880 0.455783233845379 2633 19297233
SGTC_2370 9071495 200 µM -0.111315574375083 0.446349002909993 no 1881 0.455683052797045 2659 21791103
SGTC_2271 7849410 118.62 µM -0.112045558685941 0.446048791204097 no 1882 0.45539364168441 2571 972430
SGTC_2941 9056145 11.23 µM -0.112091137815976 0.446030047457583 no 1883 0.455375572070348 2575 2119517
SGTC_2749 bexarotene 57.39 µM -0.112989842050721 0.445660493252162 no 1884 0.455019304254631 2683 82146 An retinoic acid receptor inhibitor.
SGTC_1814 st052110 31.539 µM -0.113481981616931 0.445458141599174 no 1885 0.454824223691327 2640 674163
SGTC_2585 alliin 100 µM -0.113854063866605 0.445305163007204 no 1886 0.454676740209409 2717 87310 A garlic compound which reacts with lipids.
SGTC_2885 9057732 51.95 µM -0.115399718719337 0.44466976701676 no 1887 0.454064150951568 2727 6471414
SGTC_792 4534-1957 155 µM -0.115704878525856 0.444544337057352 no 1888 0.453943219860109 2682 1717904
SGTC_2967 9089538 49.85 µM -0.115817536409945 0.444498032644234 no 1889 0.453898575999853 2700 728216
SGTC_1383 3049-0032 20.7 µM -0.116157100867845 0.444358470140058 no 1890 0.453764017543647 2730 712864
SGTC_2452 5863136 48.41 µM -0.116949669838016 0.444032747636246 no 1891 0.453449968668939 2594 2184096
SGTC_2305 7443522 69.23 µM -0.117072721501222 0.443982180411274 no 1892 0.453401213074457 2635 5415886
SGTC_2387 9077560 195.08 µM -0.117304001246409 0.443887140077432 no 1893 0.453309577193862 2590 5303272
SGTC_280 3448-3607 3.04 µM -0.11748244067505 0.443813815745184 no 1894 0.453238878995508 2616 626179
SGTC_54 0159-0055 9 µM -0.118057210696155 0.443577644329292 no 1895 0.453011163599798 2641 3319099
SGTC_2716 st080858 38.6235 µM -0.118512942869049 0.443390399476276 no 1896 0.452830620220867 2669 5296050
SGTC_935 2996-0153 430 µM -0.119255381143381 0.44308538392199 no 1897 0.45253651592356 2625 23738523
SGTC_2906 7926292 26.41 µM -0.119851318711892 0.442840579571035 no 1898 0.452300464220634 2732 2966319
SGTC_1668 st014914 51.6 µM -0.120418522658356 0.442607598929697 no 1899 0.452075809603697 2622 2839556
SGTC_1799 st045822 46.1415 µM -0.121219140374609 0.442278776710689 no 1900 0.451758732041235 2627 3674992
SGTC_838 0109-0203 71.4 µM -0.121962627015255 0.441973454436567 no 1901 0.451464308287115 2623 759422
SGTC_2447 5741742 33.78 µM -0.122054029849621 0.441935921072266 no 1902 0.451428114229941 2697 1776504
SGTC_2676 harmalol 100 µM -0.122403338840618 0.4417924867637 no 1903 0.451289797191852 2631 5459187 A monoamine oxidase inhibitor
SGTC_2956 9076196 2.52 µM -0.122748378707088 0.441650812948626 no 1904 0.45115317641894 2677 16423868
SGTC_1246 0422-0085 105 µM -0.122794267638159 0.441631971456235 no 1905 0.451135006834661 2653 264295
SGTC_481 bay k-8644 50 µM -0.122838973870045 0.441613615694186 no 1906 0.451117305635026 2628 2303 A calcium channel antagonist.
SGTC_3119 9125183 49.47 µM -0.124812134668439 0.440803588549266 no 1907 0.450336140220912 2611 22695334
SGTC_2237 6667747 47.222 µM -0.12524788154014 0.440624737862106 no 1908 0.450163655835538 2677 729940 YDL015C TSC13
SGTC_739 1486-1183 203 µM -0.125348236560573 0.440583549230782 no 1909 0.450123933018153 2627 4346692
SGTC_1296 1068-0102 11.9 µM -0.12628689962821 0.440198325678937 no 1910 0.449752412908056 2733 767053
SGTC_60 0986-0278 202 µM -0.127155471478476 0.439841917690325 no 1911 0.449408673918583 2628 3110598
SGTC_2334 9017922 200 µM -0.127159014934724 0.439840463775414 no 1912 0.449407271666498 2769 3163164
SGTC_1187 1391-0724 117 µM -0.128454350957112 0.439309029194217 no 1913 0.448894710762437 2669 6997986
SGTC_39 0986-0283 58.349 µM -0.129361136193958 0.438937069484413 no 1914 0.448535949030812 2710 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.131316104244891 0.438135333185422 no 1915 0.447762626379958 2760 5393153
SGTC_350 k064-0020 19.8 µM -0.131973220441469 0.437865905362343 no 1916 0.447502736720892 2761 2790705
SGTC_3274 9138298 49.47 µM -0.131982614659773 0.4378620537958 no 1917 0.447499021467783 2619 17015756
SGTC_958 1222-0007 33 µM -0.132721647849245 0.437559073618393 no 1918 0.447206760908007 2776 7312461
SGTC_3240 9133527 49.47 µM -0.132735292649125 0.437553480026684 no 1919 0.447201365158414 2643 17617455
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.133584819452553 0.437205246987348 no 1920 0.446865444455253 2695 4330530
SGTC_2127 5253358 187.912 µM -0.133912625463446 0.437070887663562 no 1921 0.446735833267527 2631 20612
SGTC_3325 9138760 55.175 µM -0.134193469881612 0.436955782471035 no 1922 0.446624794744238 2673 43844959
SGTC_476 mead acid 10 µM -0.135121988692961 0.436575263416199 no 1923 0.44625771257403 2649 5312531 An omega 9 fatty acid.
SGTC_1243 0416-0003 5.65 µM -0.135188315568953 0.436548084043457 no 1924 0.446231492555278 2717 2141977
SGTC_405 ebelactone b 50 µM -0.135247551016171 0.436523810843797 no 1925 0.446208076084476 2658 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2141 5621638 7.665 µM -0.135261992056574 0.436517893304095 no 1926 0.446202367399352 2766 2856238
SGTC_859 0439-0102 54.6 µM -0.136232656894362 0.436120174286156 no 1927 0.445818679677764 2631 610143
SGTC_1634 st006576 41 µM -0.13641249051788 0.436046496557298 no 1928 0.445747599986976 2722 3915356
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.137166253090606 0.435737704652536 no 1929 0.445449692436348 2696 6857784
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.138320956154113 0.435264736559 no 1930 0.444993382043503 2665 688669
SGTC_809 3998-0021 90 µM -0.140224138156186 0.434485392768917 no 1931 0.444241450415292 2640 715485
SGTC_1076 itraconazole 331 nM -0.140740883277919 0.434273831959497 no 1932 0.444037323170941 2642 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1864 st057645 30.4 µM -0.141143802869431 0.434108885559006 no 1933 0.443878170154756 2669 688666
SGTC_2172 5754775 163.918 µM -0.141797633372776 0.433841246185506 no 1934 0.44361992673799 2676 2263357
SGTC_1620 st003704 16.5 µM -0.142170267725623 0.433688725374566 no 1935 0.443472758060981 2674 2834414
SGTC_1732 st034308 51.822 µM -0.14387899509939 0.432989462842867 no 1936 0.442798011286487 2618 830119
SGTC_37 0566-0070 1.56 µM -0.143914144455672 0.432975080865631 no 1937 0.442784133150378 2777 1626686
SGTC_2490 carminic acid 95.39 µM -0.144232013520692 0.432845023181725 no 1938 0.442658631050642 2614 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2263 7948595 193.29 µM -0.144314202898167 0.432811396178641 no 1939 0.442626181708578 2655 2971371
SGTC_3093 9117344 49.47 µM -0.145129254719095 0.432477951843585 no 1940 0.44230441044052 2816 24824913
SGTC_718 1130-0073 349 µM -0.14765960649622 0.431443071716309 no 1941 0.441305705724421 2790 6740020
SGTC_131 0141-0277 33.849 µM -0.149200602838425 0.430813054780729 no 1942 0.440697672160833 2820 1547771
SGTC_2179 6298986 200 µM -0.149841452176928 0.430551103337806 no 1943 0.440444852212378 2758 738374
SGTC_471 1-acyl-paf 4 µM -0.1529488962982 0.429281350174498 no 1944 0.439219287917717 2654 16759367
SGTC_2858 9025781 8.96 µM -0.15357794202822 0.429024400251711 no 1945 0.438971265144444 2779 4894980 YPL153C RAD53
SGTC_1157 4092-0394 27.6 µM -0.153638546478087 0.428999646390543 no 1946 0.438947371033112 2860 3659885
SGTC_2622 2-methoxyxanthone 59.94 µM -0.153749879429088 0.428954173222916 no 1947 0.438903477114559 2758 71034 A hepatoprotective.
SGTC_1496 4469-0713 57.4 µM -0.154702485867625 0.428565126377582 no 1948 0.438527935075648 2692 746691
SGTC_1622 st003707 19.4 µM -0.156161182430117 0.427969525700366 no 1949 0.437952986614911 2797 10140899
SGTC_2918 7977171 22.06 µM -0.156555617831484 0.427808501829866 no 1950 0.437797541476055 2645 2236483
SGTC_1940 st075990 51.1 µM -0.156987507364349 0.427632201516354 no 1951 0.437627346849824 2936 1084979
SGTC_1572 epiandrosterone 68.9 µM -0.157803119148683 0.427299302543604 no 1952 0.437305970365349 2688 441302 A steroid.
SGTC_3084 9116877 49.47 µM -0.158477568309664 0.427024059398553 no 1953 0.43704024759088 2670 27241325
SGTC_1410 3909-8106 77.9 µM -0.158512385829905 0.427009851308868 no 1954 0.437026530784101 2760 1039210
SGTC_1118 chelidonine 707.474 nM -0.160322962068065 0.426271134960062 no 1955 0.436313335856703 2701 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3300 9124615 50.48 µM -0.161793732276198 0.425671249937879 no 1956 0.435734144465867 2867 24824903
SGTC_376 3970-0862 59.1 µM -0.162301056746158 0.425464366651136 no 1957 0.435534391275482 2799 3135186
SGTC_3172 9105863 49.47 µM -0.162640724493561 0.425325864040538 no 1958 0.435400660185393 2735 2348785
SGTC_950 1165-0508 94.1 µM -0.162945899523993 0.425201434007104 no 1959 0.435280515573772 2778 6148369
SGTC_1035 k081-0041 55.2 µM -0.164361552390181 0.424624322776583 no 1960 0.434723264328064 2672 731709
SGTC_2180 6301957 200 µM -0.165356212912186 0.424218931672479 no 1961 0.434331808102874 2731 845462
SGTC_2129 girgensonine 121.053 µM -0.16537554830406 0.424211051991943 no 1962 0.434324199148796 2763 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_728 3030-5151 22.5 µM -0.165938332907002 0.423981715756326 no 1963 0.434102740184426 2691 3125388
SGTC_3144 9087057 49.47 µM -0.166046084493312 0.423937809629522 no 1964 0.434060341674826 2666 17249618
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.166994670193459 0.423551325039814 no 1965 0.433687121304278 2840 6728940
SGTC_3222 9128301 49.47 µM -0.167321309770917 0.423418258480372 no 1966 0.433558618860861 2733 4911358
SGTC_2276 7947513 42.08 µM -0.167412687607011 0.423381034504381 no 1967 0.433522671395904 2794 2105100
SGTC_3043 9092303 49.47 µM -0.16856871290681 0.422910171393241 no 1968 0.433067945909801 2729 25236084
SGTC_1323 1348-1351 11.2 µM -0.169530048840478 0.422518691443357 no 1969 0.43268986943197 2719 6989654
SGTC_2126 5251174 33.877 µM -0.170662429439335 0.422057656022783 no 1970 0.432244603158772 2813 790722
SGTC_555 4296-0685 37 µM -0.172295427111281 0.421392988450996 no 1971 0.431602639616159 2681 2908540 YHR072W ERG7
SGTC_71 0417-1750 47.813 µM -0.173412400098698 0.420938483630021 no 1972 0.431163639448818 2907 6811472
SGTC_391 gliotoxin 8.33 µM -0.174520623665216 0.420487643129387 no 1973 0.430728162064164 2852 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2002 4023503 131 µM -0.174915376244993 0.420327077540704 no 1974 0.430573064020134 2744 4736863 YCR052W RSC6
SGTC_464 bw-b 70c 158 µM -0.175988227824095 0.419890762275751 no 1975 0.430151595469092 2862 5353454
SGTC_1198 1612-1005 86.7 µM -0.176026365849004 0.419875253828819 no 1976 0.430136614450149 2913 6998509
SGTC_561 1550-0330 72.9 µM -0.176385586893915 0.419729186287122 no 1977 0.429995513567894 2738 6812934
SGTC_1237 0330-0133 46.1 µM -0.177640323527589 0.419219068402486 no 1978 0.429502727280468 2731 X1237 YHR072W ERG7
SGTC_2653 dihydrofissinolide 100 µM -0.177900377849626 0.419113359298294 no 1979 0.42940060704937 2774 6857746
SGTC_551 k048-0028 34.9 µM -0.178141596043636 0.419015312083976 no 1980 0.429305887764442 2874 6836383
SGTC_1831 st055328 12 µM -0.179245545926144 0.418566657254268 no 1981 0.428872451157106 2854 1103068
SGTC_894 0960-0238 55.9 µM -0.179459578196743 0.418479684918297 no 1982 0.428788426978746 2708 6741907 YDL195W SEC31
SGTC_2863 9028737 58.44 µM -0.179843988319293 0.418323489294159 no 1983 0.428637524455138 2836 6460917
SGTC_614 0462-0418 107 µM -0.180821176174934 0.417926491014758 no 1984 0.428253970454927 2739 5188303
SGTC_1531 st059297 52.4 µM -0.180926143371927 0.417883851369499 no 1985 0.428212774020166 2846 7566702
SGTC_2511 berberine 10.47 µM -0.181307926573848 0.417728772012254 no 1986 0.428062942317196 2743 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2935 9038016 29.96 µM -0.182367279444195 0.417298532664686 no 1987 0.42764725120502 2817 6463195
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.182629222205995 0.417192164017783 no 1988 0.427544476971826 2729 16623 A steroid.
SGTC_3221 9128209 49.47 µM -0.184120320663836 0.416586780511078 no 1989 0.426959532705635 2781 16460723
SGTC_3151 9099821 49.47 µM -0.184127162898565 0.416584003029883 no 1990 0.426956848928761 2853 17174189
SGTC_763 3453-1109 128 µM -0.184382958020928 0.416480170624636 no 1991 0.426856519072397 2743 1560353
SGTC_2805 7950783 58.44 µM -0.184384529937603 0.416479532569925 no 1992 0.426855902538225 2860 1178958 YDL195W SEC31
SGTC_2922 7999257 32.47 µM -0.185160092895321 0.416164751662737 no 1993 0.426551734531708 2716 2988377
SGTC_284 0988-0104 32.6 µM -0.185941485228435 0.415847659138504 no 1994 0.426245324473183 2835 4666532
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.186943983911199 0.415440920912663 no 1995 0.4258522764405 2882 5377381
SGTC_2443 5493264 126.67 µM -0.18846774965744 0.414822865522531 no 1996 0.425254997260746 2907 5340055
SGTC_2670 beta-carotene 100 µM -0.189163222513638 0.414540844390543 no 1997 0.424982445706442 2816 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_586 0957-0265 8.15 µM -0.190682633772196 0.413924861501568 no 1998 0.424387122641984 2758 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_185 k048-0037 25.491 µM -0.190863387482598 0.413851596395436 no 1999 0.424316312680953 2811 6827589
SGTC_1279 0874-0590 65.2 µM -0.191195581655802 0.413716955576133 no 2000 0.424186182546061 2804 3523074
SGTC_1514 1189-1591 158 µM -0.191313116950832 0.413669320057625 no 2001 0.424140142525756 2952 767698 YMR146C TIF34
SGTC_3313 9133968 57.047 µM -0.191813893865362 0.41346637596705 no 2002 0.423943993660027 2721 1494643
SGTC_2110 5483698 200 µM -0.192198396093987 0.413310568863693 no 2003 0.423793401106903 2797 2848765 YHR062C RPP1
SGTC_1183 1254-0324 198 µM -0.192302006890693 0.41326858627027 no 2004 0.423752823233171 2865 5799357
SGTC_2107 5363541 170.161 µM -0.193072875252409 0.412956265308196 no 2005 0.42345094768512 2762 244052
SGTC_864 0469-0573 172 µM -0.193146735413365 0.412926343403533 no 2006 0.423422026066727 2726 689425
SGTC_2898 9056270 58.44 µM -0.19367077066443 0.412714063076446 no 2007 0.423216840055824 2722 19154699
SGTC_1399 3562-5772 25 µM -0.1937233976278 0.412692745941019 no 2008 0.423196235117192 2709 23847490
SGTC_154 3389-1638 511.116 µM -0.193736993058618 0.412687239002769 no 2009 0.423190912157192 2844 5238686
SGTC_1652 st011932 78 µM -0.194376593549747 0.412428183136343 no 2010 0.422940508015422 2830 1551076
SGTC_3220 9131269 49.47 µM -0.19452593820679 0.412367699914105 no 2011 0.422882043933128 2696 17722206
SGTC_2086 5274770 176.623 µM -0.194579248660514 0.412346110171142 no 2012 0.422861174854902 2822 689278
SGTC_84 0443-0269 128.823 µM -0.195306091350046 0.412051778877773 no 2013 0.422576664345038 2753 6150058
SGTC_901 1112-0062 60.1 µM -0.195349512669758 0.412034197196823 no 2014 0.422559669066887 2752 1908457
SGTC_699 0375-0592 111 µM -0.196229476271899 0.411677930153204 no 2015 0.422215278900897 2799 762578
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.197291252963619 0.411248150174603 no 2016 0.421799811975439 2902 5282362
SGTC_1766 st045414 44.774 µM -0.198337680746249 0.41082468722858 no 2017 0.421390436129692 2750 253960
SGTC_1197 1601-0112 267 µM -0.19952495826283 0.410344351799948 no 2018 0.420926060979294 2755 7350313
SGTC_1379 2144-0755 36.5 µM -0.199725841450243 0.4102630940123 no 2019 0.420847501196672 2870 5392327
SGTC_594 1487-1584 10.8 µM -0.200186421794112 0.410076802577041 no 2020 0.420667393039711 2788 5013332
SGTC_3356 9151811 4.48 µM -0.200386468066748 0.409995895961075 no 2021 0.42058917089107 2747 1859254 YPR165W RHO1
SGTC_2049 5262831 67.185 µM -0.201052222798342 0.409726666057669 no 2022 0.420328869891233 2826 763417
SGTC_2966 9084041 48.03 µM -0.201312225823082 0.409621532895274 no 2023 0.420227221716353 2711 17741380
SGTC_1343 1487-0095 224 µM -0.201903974579441 0.409382281384523 no 2024 0.419995897401447 2779 4560101 YGL055W OLE1
SGTC_98 0074-0023 107.663 µM -0.202480051422482 0.409149398643654 no 2025 0.419770726042349 2842 3563821
SGTC_105 0111-0055 734.78 µM -0.203065925056297 0.408912588372485 no 2026 0.419541752345721 2844 5179370
SGTC_2426 5582046 32.21 µM -0.203915186433139 0.408569375754251 no 2027 0.419209888680339 2911 2251934
SGTC_904 1141-0088 396 µM -0.205377452973727 0.407978593337443 no 2028 0.418638617362526 2808 1378119
SGTC_1688 st021091 57.6 µM -0.205463849595688 0.407943694053419 no 2029 0.418604869697791 2791 3656366
SGTC_2793 7325131 81.82 µM -0.205873733872147 0.407778134251934 no 2030 0.418444771637957 2848 4176441
SGTC_265 mycophenolic acid 32.932 µM -0.206800471495729 0.407403868623278 no 2031 0.418082843955425 3017 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_974 1326-0144 138 µM -0.210317405552159 0.405984316468358 no 2032 0.416709975709039 2788 5411856
SGTC_307 1501-1223 22.3 µM -0.211467213184128 0.40552048268765 no 2033 0.416261356894444 2844 2830329
SGTC_367 0335-0881 7.1 µM -0.211634548257634 0.405452990558858 no 2034 0.416196077083895 2928 23828853
SGTC_1481 3346-2004 36 µM -0.21213352123532 0.405251753879055 no 2035 0.416001434304868 2801 2770522
SGTC_2416 tofa 880 nM -0.212883744053012 0.404949234851607 no 2036 0.41570882106471 2803 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3328 9140624 29.0385 µM -0.213537058278314 0.404685839395668 no 2037 0.415454043637797 2951 4904392
SGTC_1508 1080-0625 72.9 µM -0.214524401307786 0.404287856163845 no 2038 0.41506907018504 2761 767111
SGTC_980 1473-0395 201 µM -0.214833297534212 0.404163365025444 no 2039 0.414948645643861 2781 768876
SGTC_1950 st077106 7.18 µM -0.214866136605816 0.404150130816544 no 2040 0.414935843658309 2876 13831864
SGTC_2701 st077767 14.721 µM -0.215021437675031 0.404087545673804 no 2041 0.414875302304535 2811 5721188
SGTC_1439 4092-1168 46 µM -0.215904134309988 0.403731872357924 no 2042 0.414531237195619 2816 2886240
SGTC_1380 2291-0730 164 µM -0.218171511699432 0.402818621971323 no 2043 0.413647740402608 2883 2999191
SGTC_3028 9087778 49.47 µM -0.219240255910309 0.402388338470191 no 2044 0.413231449253474 2783 17217395
SGTC_3334 9142812 21.919 µM -0.219906455093194 0.402120182054014 no 2045 0.412972004464894 2919 45283678
SGTC_1367 1812-0510 76.9 µM -0.220037820782633 0.402067310579752 no 2046 0.41292084985814 2834 1142582 YDR527W RBA50
SGTC_1606 st000094 49.2 µM -0.22233837631852 0.401141684596805 no 2047 0.412025239831878 2846 1242210
SGTC_1011 4112-3381 17.4 µM -0.222790553016948 0.400959816854408 no 2048 0.411849260418738 2970 2877139
SGTC_1467 k284-1082 293 µM -0.223417254058232 0.400707790036103 no 2049 0.411605388443945 2914 3334705
SGTC_1530 rhein 70.4 µM -0.224476380236486 0.400281958129364 no 2050 0.411193321912278 2785 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2740 felodipine 17.08 µM -0.225565640065728 0.399844134320842 no 2051 0.410769633680999 2904 3333 L-type calcium channel blocker
SGTC_2954 9074818 52.69 µM -0.226376287995371 0.399518379167629 no 2052 0.410454384352884 2955 16648742
SGTC_3278 9139605 49.47 µM -0.227117391037603 0.399220631497042 no 2053 0.410166230642479 3010 7958859
SGTC_1301 naphtanilide LB 4.81 µM -0.228085707683294 0.398831686195671 no 2054 0.409789805446735 2935 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1106 tegaserod maleate 11.7 µM -0.228381409232544 0.398712931281635 no 2055 0.409674870435279 2857 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_342 k048-0088 23.3 µM -0.228679452637932 0.398593245357467 no 2056 0.409559033031539 2769 6820570
SGTC_895 0964-0006 13.7 µM -0.230644022180676 0.397804568098393 no 2057 0.408795682379612 2915 6738897
SGTC_3050 9093513 49.47 µM -0.231783231203806 0.397347423177628 no 2058 0.408353190989786 2819 25236664
SGTC_45 0kpi-0036 14.9 µM -0.231795608015524 0.397342457349659 no 2059 0.408348384231045 2938 2795021
SGTC_1787 fluconazole 80 µM -0.231863273143938 0.397315309021483 no 2060 0.40832210549809 2857 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_380 3970-0968 6 µM -0.231995927513774 0.397262087417357 no 2061 0.408270588448186 2830 2891601
SGTC_631 k072-0230 41.5 µM -0.232230705259364 0.397167898087601 no 2062 0.408179415113456 2920 5773147
SGTC_2287 7945887 168.79 µM -0.232615502993857 0.397013535947714 no 2063 0.408029993931535 2918 1245853
SGTC_1967 st070177 51.4 µM -0.235657712652465 0.395793719191634 no 2064 0.406849143079701 2994 5729214
SGTC_377 3970-0964 33.1 µM -0.236025724135154 0.395646228725333 no 2065 0.406706354518361 2805 16481235
SGTC_2436 5633522 8.09 µM -0.236698604974781 0.395376592344584 no 2066 0.406445308640784 2967 5724242
SGTC_1319 1306-0155 43.7 µM -0.237562047582009 0.39503066755004 no 2067 0.406110394744841 2822 3122360
SGTC_808 0711-0032 135 µM -0.238082518016596 0.394822189141337 no 2068 0.40590854676853 2804 4252555
SGTC_12 0849-0099 9.267 µM -0.238955587830335 0.394472542008811 no 2069 0.405570010480147 2850 6071388
SGTC_670 4204-0025 119 µM -0.240689969636178 0.393778208925996 no 2070 0.404897706770648 2945 719039
SGTC_3062 9077494 49.47 µM -0.241049121198534 0.393634470237116 no 2071 0.404758522760533 2955 16459633
SGTC_2804 7954240 19.48 µM -0.242317048789348 0.39312713962793 no 2072 0.404267252170791 2992 828705
SGTC_638 3970-0837 4.09 µM -0.242374751336298 0.393104055657466 no 2073 0.404244898355504 2861 4118451 YLR208W SEC13
SGTC_2568 diosmetin 100 µM -0.243095837854307 0.392815615886014 no 2074 0.4039655777175 2969 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3258 9138477 49.47 µM -0.243481212729338 0.392661487295532 no 2075 0.403816318670085 2858 4970355
SGTC_170 4197-0004 226 µM -0.243603481350399 0.392612590139913 no 2076 0.403768965893142 2973 218692
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.243703607523884 0.392572549361628 no 2077 0.403730189599663 2848 5106787 A p450 inhibitor.
SGTC_3142 9086498 49.47 µM -0.2444115638331 0.392289467826186 no 2078 0.4034560433351 2974 25236367
SGTC_2724 maprotiline 69.64 µM -0.244685271276484 0.392180039159988 no 2079 0.403350066629584 2888 4011 A tricyclic antidepressant.
SGTC_754 3474-0146 171 µM -0.244944791305822 0.392076290518919 no 2080 0.403249589699639 2825 24762078
SGTC_875 0709-0210 25.7 µM -0.245132657706539 0.392001191723862 no 2081 0.403176858492404 2822 6251364
SGTC_2991 9074669 71.4286 µM -0.246378288540799 0.391503357990493 no 2082 0.402694705775208 3038 17333109
SGTC_1327 1436-0082 2.18 µM -0.251144138676962 0.389600266277231 no 2083 0.40085133573111 2881 15992205
SGTC_1378 2093-0007 380 nM -0.252735003050074 0.388965591213174 no 2084 0.400236498619999 2966 3618014
SGTC_652 0437-0092 114 µM -0.252981584282858 0.388867244143226 no 2085 0.400141222015242 2859 3091274
SGTC_881 0833-0569 170 µM -0.253726914255961 0.388570018207682 no 2086 0.399853269872711 2874 5418700
SGTC_2229 7354935 190 µM -0.255507664467055 0.387860147271979 no 2087 0.399165512319243 2941 318112
SGTC_2992 9074591 71.4286 µM -0.255618721898215 0.387815888180215 no 2088 0.399122630297745 2967 17741321
SGTC_3130 9127414 49.47 µM -0.25562027177774 0.387815270525778 no 2089 0.399122031859531 2819 1494646
SGTC_3269 9137823 49.47 µM -0.256595325586414 0.387426750639423 no 2090 0.398745591929784 2839 17682936
SGTC_1958 st076513 41.9 µM -0.259124368854961 0.386419554418306 no 2091 0.397769641571128 2842 732122 YGL099W LSG1
SGTC_1324 1418-0026 34.4 µM -0.260672561231266 0.385803360826555 no 2092 0.397172513814541 2973 1372513
SGTC_973 1325-0077 65.9 µM -0.262227911993774 0.385184608161959 no 2093 0.396572867725433 2933 2835149
SGTC_1658 st012944 20 µM -0.262657587571405 0.385013725231759 no 2094 0.396407254713311 2935 24207260
SGTC_2869 9037858 32.47 µM -0.2626927830487 0.384999728901381 no 2095 0.396393689889892 2832 27187042
SGTC_991 3996-0057 64.7 µM -0.26380866721762 0.384556048425328 no 2096 0.395963677813627 2955 715343
SGTC_1609 st001574 46.4 µM -0.264061608511358 0.384455498845965 no 2097 0.395866223079283 2865 3960012
SGTC_1713 st033146 12.748 µM -0.264206110146119 0.384398059841083 no 2098 0.395810551546295 3018 674619
SGTC_2566 crystal violet carbinol 226 nM -0.265107303495431 0.384039895269917 no 2099 0.395463400603916 3032 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1745 st081495 74 µM -0.268936106030778 0.38251930763796 no 2100 0.393989425793329 2874 13842402 YBL026W LSM2
SGTC_2642 cholecalciferol 100 µM -0.270042083761825 0.382080410535537 no 2101 0.393563938842113 2978 9821465 A vitamin D precursor, similar to steriods.
SGTC_2643 anethole 100 µM -0.272176407393389 0.381233852511894 no 2102 0.392743190731226 2947 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1635 st007035 42.4 µM -0.273929833245611 0.380538798547078 no 2103 0.39206927226872 2930 3716403
SGTC_2786 7743617 45.45 µM -0.275808439749094 0.379794550988719 no 2104 0.391347600537797 2933 583674
SGTC_134 0269-0018 6.916 µM -0.276218901376938 0.37963199754728 no 2105 0.391189970282374 2967 4378915
SGTC_2734 clemastine 41.6 µM -0.277663183757854 0.379060193572631 no 2106 0.390635462372812 2912 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_505 gw-5074 63.9 µM -0.27907982462435 0.378499590080434 no 2107 0.390091782935412 2991 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_784 4579-0127 173 µM -0.279511083612694 0.378328979813978 no 2108 0.389926316677397 3092 1948547
SGTC_423 5-fluorouracil 457 µM -0.279743849149244 0.378236905348399 no 2109 0.389837017045055 2835 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2730 imipramine 71.33 µM -0.280542335968345 0.377921102539819 no 2110 0.389530724759808 2911 3696 A tricyclic antidepressant.
SGTC_87 0100-0052 35.5 µM -0.28156115034107 0.377518278284765 no 2111 0.3891400164635 2988 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_201 4262-0159 12.803 µM -0.282866471529007 0.377002368136627 no 2112 0.388639598590985 2976 1341029
SGTC_2402 5553605 200 µM -0.28345811026224 0.376768603347024 no 2113 0.388412844254671 3102 6758546
SGTC_1006 4099-6547 255 µM -0.283906016092187 0.376591659489973 no 2114 0.388241202975637 3001 3146833
SGTC_3297 9117502 71.43 µM -0.285234577999076 0.376066967712155 no 2115 0.387732215385477 2973 7453720
SGTC_3 0833-0587 95.581 µM -0.286905824583059 0.375407264062242 no 2116 0.38709221526517 2961 5382644
SGTC_1820 st053765 18.6 µM -0.28749524728539 0.375174683605788 no 2117 0.386866570265388 2970 3690829
SGTC_1283 0922-0125 16.4 µM -0.287624904053131 0.375123528393833 no 2118 0.386816939705127 3019 3360884
SGTC_1362 1611-0397 101 µM -0.287694933238806 0.37509589975969 no 2119 0.386790134410048 2921 27816
SGTC_303 1348-1668 34.2 µM -0.288126182741126 0.37492577290323 no 2120 0.386625075567919 2943 5380509
SGTC_302 1094-0063 18.9 µM -0.289149817977509 0.374522048835669 no 2121 0.386233365866899 2895 5440289
SGTC_2999 9069765 71.4286 µM -0.290189027240019 0.374112323007316 no 2122 0.38583581510978 2999 2097066
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.291602362377898 0.373555319948869 no 2123 0.385295334493245 3099 94937 An inhibitor of serotonin biosynthesis.
SGTC_2790 5423970 71.43 µM -0.291732762743911 0.373503941743249 no 2124 0.38524547863839 3105 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1459 k035-0031 35.7 µM -0.291747848394005 0.373497998088817 no 2125 0.385239711077716 2883 3877128 YMR208W ERG12
SGTC_1426 4048-4480 71.7 µM -0.292451993902611 0.373220602544958 no 2126 0.384970529734965 3030 14224343
SGTC_1270 0831-1170 17.3 µM -0.292900895532559 0.373043793675098 no 2127 0.384798952161932 2907 6764716
SGTC_2448 5185112 27.17 µM -0.293268948861367 0.372898848467367 no 2128 0.3846582929654 3057 5718189
SGTC_2221 6807166 181.081 µM -0.294834874502546 0.372282363582737 no 2129 0.384060011989948 2991 674925
SGTC_2976 9009005 19.48 µM -0.294986524323328 0.372222678340161 no 2130 0.384002086973287 3132 2993148
SGTC_2572 astragaloside iv 100 µM -0.297307994896677 0.371309394620893 no 2131 0.383115689208845 3100 45006101 An anti-inflammatory agent.
SGTC_2684 capsaicin 100 µM -0.297309233261311 0.371308907631869 no 2132 0.383115216531881 3018 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_26 0302-0163 425.158 µM -0.297704586577807 0.37115344479599 no 2133 0.38296432124719 2931 3100915
SGTC_2225 6654152 15.4 µM -0.297868109817263 0.371089149503146 no 2134 0.3829019141985 2990 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1812 st052057 4.327 µM -0.302938532499475 0.369097316456689 no 2135 0.380968352778152 2900 3645418
SGTC_2439 5492030 7.2 µM -0.303397385801009 0.368917235800646 no 2136 0.380793518838424 3051 5722370
SGTC_1453 4237-0541 195 µM -0.30367890247427 0.36880676656456 no 2137 0.380686266384581 3063 739892
SGTC_1316 1272-0050 65.9 µM -0.304452352342114 0.368503314905341 no 2138 0.380391644040363 2946 7340392
SGTC_1565 sinapyl alcohol 95.1 µM -0.304475337852546 0.368494298132603 no 2139 0.380382889465664 3033 5280507 A phenol propionate derived from cinnamic acid.
SGTC_159 3970-0959 50 µM -0.304688385349326 0.368410727152434 no 2140 0.380301748209403 3030 6615653
SGTC_14 0354-0009 295 µM -0.305776240473835 0.367984097270543 no 2141 0.379887509955593 2927 1713507
SGTC_168 3970-0862 530.542 µM -0.306055617859924 0.367874558618295 no 2142 0.379781149623137 3031 3135186
SGTC_167 3672-0051 66.205 µM -0.306507172409643 0.367697535238119 no 2143 0.379609259836336 2884 3237971
SGTC_727 3032-0951 202 µM -0.306964588591626 0.367518242568702 no 2144 0.379435163001257 2994 3652836
SGTC_2343 7990716 14.84 µM -0.307144302474457 0.367447808311645 no 2145 0.379366768919578 2924 6456862
SGTC_2236 dapsone 200 µM -0.307539110346489 0.367293089131545 no 2146 0.379216529335764 2983 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1932 st074806 40.9 µM -0.307684605041638 0.367236077412103 no 2147 0.379161167605533 3178 17251235
SGTC_692 k241-0027 77.8 µM -0.307963969780295 0.367126617269323 no 2148 0.379054874353498 3119 3600480
SGTC_1857 st056007 79.3 µM -0.308709556331166 0.366834535905738 no 2149 0.37877123688841 3024 619834
SGTC_1288 0973-0013 65.5 µM -0.308751875430743 0.366817959831602 no 2150 0.378755139731772 3054 4315430
SGTC_2306 7482397 179.52 µM -0.309240741427336 0.366626492696258 no 2151 0.378569202246822 3119 891448
SGTC_938 3126-1755 342 µM -0.31063625097617 0.366080116193779 no 2152 0.37803858266118 3128 1777771
SGTC_1151 3909-8316 15.3 µM -0.311402806733124 0.365780106085181 no 2153 0.377747210221889 3060 800431
SGTC_2138 5575593 77.673 µM -0.311720703562846 0.365655713546988 no 2154 0.377626396122599 2971 762213
SGTC_156 3474-0145 5.642 µM -0.311810679037827 0.365620508846972 no 2155 0.377592203849822 2925 2265471
SGTC_2338 7999974 200 µM -0.312057751533069 0.365523842625187 no 2156 0.377498316863693 3014 315925
SGTC_3293 9120939 62.045 µM -0.31206550073515 0.365520810915951 no 2157 0.377495372301579 3099 934087
SGTC_1340 1486-1359 257 µM -0.312915880086228 0.365188169305427 no 2158 0.377172286228087 2960 4309068
SGTC_3162 9099653 49.47 µM -0.313245591643043 0.365059223799348 no 2159 0.377047041469548 3079 25237511
SGTC_1690 st023502 41.2 µM -0.314508713401798 0.36456537612458 no 2160 0.37656734982248 3047 24207482
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.316551241099625 0.363767276766334 no 2161 0.375792069155767 2986 688664
SGTC_3273 9137859 49.47 µM -0.31809422517338 0.363164761051961 no 2162 0.375206731980133 3049 2377234
SGTC_1119 parthenolide 318.541 nM -0.318463140670025 0.363020754308665 no 2163 0.375066824910603 3167 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_3039 9090270 49.47 µM -0.322465534957075 0.361459662037134 no 2164 0.373550021765874 3105 17173750
SGTC_2929 9013348 24.6 µM -0.322629974795 0.361395573080279 no 2165 0.3734877450437 3063 2995952
SGTC_1190 1486-1332 13 µM -0.324219336075061 0.360776334426091 no 2166 0.372885992007339 3033 4150046
SGTC_3210 9128157 49.47 µM -0.325353805345228 0.360334551462625 no 2167 0.372456656587548 3065 17590849
SGTC_598 3937-0236 20.2 µM -0.326439805614579 0.359911817825271 no 2168 0.372045812494255 3049 1379313
SGTC_465 cgp-37157 41 µM -0.326840548185086 0.35975586905424 no 2169 0.371894244578914 3031 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1889 st059080 5.18 µM -0.328988458028774 0.358920409508652 no 2170 0.371082206026727 3159 176925 Isolated from Daphnopsis sellowiana.
SGTC_1220 1838-0075 193 µM -0.329293275730545 0.358801900958342 no 2171 0.370967013081501 3010 5529645
SGTC_374 0880-0231 82.3 µM -0.331096333464148 0.358101177468976 no 2172 0.370285860534712 3052 6833587
SGTC_1202 1988-0068 29.6 µM -0.331562021301002 0.357920274437779 no 2173 0.370110000665804 2987 2850480
SGTC_1139 k015-0024 46.9 µM -0.332030914337089 0.357738158533126 no 2174 0.369932957835042 3129 2766652
SGTC_1388 3346-4487 254 µM -0.332133871006103 0.35769817496919 no 2175 0.369894087540628 3066 3345614
SGTC_1165 k072-0275 30.3 µM -0.33267900521088 0.357486496324137 no 2176 0.369688299554062 3120 6153523 YGL055W OLE1
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.333900588576168 0.357012307971404 no 2177 0.369227287816469 2938 6708630 An antioxidant.
SGTC_2103 5378138 10 µM -0.334391177211796 0.356821935736779 no 2178 0.369042198094768 3015 244142
SGTC_1861 st057647 17.4 µM -0.334913598323958 0.356619250152223 no 2179 0.368845131968783 3169 688668
SGTC_1055 3448-0672 86 µM -0.335364404564368 0.356444381780482 no 2180 0.368675107899819 3128 748378
SGTC_171 k064-0041 9.68 µM -0.335505848825635 0.356389521571315 no 2181 0.368621766709718 3013 53325
SGTC_1534 6-azauridine 81.6 µM -0.335945225836581 0.356219124886262 no 2182 0.368456085837617 2991 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_361 000s-0510 1.45 µM -0.336168048026616 0.356132722224416 no 2183 0.36837207309101 3082 660
SGTC_2398 5228213 48.84 µM -0.336587344474745 0.355970153739806 no 2184 0.36821399887154 3207 80771 YMR134W ERG29
SGTC_1686 st019653 115.5 µM -0.337759346978302 0.355515887061269 no 2185 0.367772273839158 3126 97252
SGTC_2877 9040724 71.43 µM -0.339416025605101 0.354874110622685 no 2186 0.367148173843685 3193 6463895
SGTC_2307 7538926 6.34 µM -0.339863913733601 0.354700675006414 no 2187 0.366979506685802 3037 96582
SGTC_2105 5350118 200 µM -0.339914380349238 0.354681134717633 no 2188 0.366960503413482 3023 2133313
SGTC_3350 9150499 3.57 µM -0.341956233932524 0.353890865788584 no 2189 0.366191914568196 2969 4910996 YPR165W RHO1
SGTC_1919 st067113 52.3 µM -0.342046143425352 0.353856082098088 no 2190 0.366158083397445 3138 1268243
SGTC_3026 9090633 49.47 µM -0.343639703018411 0.353239777172802 no 2191 0.365558631178868 2996 25236842
SGTC_2943 9068529 45.32 µM -0.344369255459344 0.352957752984001 no 2192 0.365284303539023 3004 3270634
SGTC_1131 3454-3128 32.3 µM -0.345103422933969 0.352674026283458 no 2193 0.365008310113497 3157 710982
SGTC_2288 7946289 167.31 µM -0.345877893552311 0.352374812811428 no 2194 0.364717241428521 3209 1246052
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.346411192929886 0.352168827926871 no 2195 0.364516857256443 3116 616764
SGTC_748 act1.228 77.9 µM -0.347468682500425 0.351760504841811 no 2196 0.364119621156495 3007 4421505 YNR035C ARC35
SGTC_3031 9088762 49.47 µM -0.347924073395822 0.351584719691477 no 2197 0.363948602742571 2957 205253
SGTC_570 0987-0065 62.6 µM -0.348763114423476 0.35126092511138 no 2198 0.363633578556441 2971 3104428
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.348780123239778 0.351254362349262 no 2199 0.363627193422534 3136 688662
SGTC_1972 st070201 17.4 µM -0.350129324186089 0.350733921722 no 2200 0.363120822270312 3148 2829099
SGTC_1741 st038134 10.228 µM -0.350552847414616 0.350570609609784 no 2201 0.362961918248498 3251 1272587
SGTC_2649 anisomycin 9.56 µM -0.351846714945697 0.350071860691396 no 2202 0.362476611161003 3079 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2147 5545932 89.7195 µM -0.352581772409717 0.34978863215586 no 2203 0.362201002300401 3059 797404
SGTC_1928 4'-methoxychalcone 40.3 µM -0.353023486775395 0.349618473252257 no 2204 0.362035416406985 3229 641818
SGTC_1393 3470-5649 58.2 µM -0.357488403120925 0.347900182140703 no 2205 0.360363103192556 3092 4108395
SGTC_49 0717-0965 32.132 µM -0.357697082339998 0.347819949459615 no 2206 0.360285008397009 3290 5889349 YGL099W LSG1
SGTC_2969 9091408 28.7 µM -0.358490664720587 0.347514896321571 no 2207 0.359988076388019 2990 4286311
SGTC_674 0498-0004 451 µM -0.358915891352441 0.347351479775586 no 2208 0.35982900553529 3102 4231473
SGTC_1441 4106-0040 13 µM -0.359553469980536 0.347106508552163 no 2209 0.359590542506737 3052 2904180
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.360093752978918 0.346898970364877 no 2210 0.359388512140527 3049 6708784 An antioxidant flavonoid
SGTC_3320 9137005 35.139 µM -0.361052871117856 0.346530658748861 no 2211 0.359029961777153 3085 4908713
SGTC_2759 disulfiram 3.38 µM -0.361733341085588 0.346269438937387 no 2212 0.358775654662377 3004 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_820 1582-0060 59.9 µM -0.362336217125874 0.34603806707423 no 2213 0.358550398452051 3060 3848840
SGTC_3111 9122088 49.47 µM -0.362426566344796 0.346003397785897 no 2214 0.358516644966015 3073 16876704
SGTC_3214 9129694 49.47 µM -0.362924475863057 0.345812360432937 no 2215 0.358330651217819 3197 17158655
SGTC_259 usnic acid 108.925 µM -0.363036617116292 0.345769339619115 no 2216 0.358288765567489 3251 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1372 2752-0194 270 µM -0.365773722290162 0.344719921030667 no 2217 0.357266964841663 3042 823334
SGTC_3262 9137218 49.47 µM -0.365894972752155 0.344673460604435 no 2218 0.357221723902011 2958 17650664
SGTC_275 trichlorophene 5.69 µM -0.368705155397624 0.343597319996078 no 2219 0.356173752818733 3142 62616
SGTC_1065 prochlorperazine maleate 2.48 µM -0.372287749589538 0.342227226519406 no 2220 0.354839309296913 3106 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2231 micatex 6.853 µM -0.373587213316102 0.341730783542467 no 2221 0.354355724266394 3116 20737 An antifungal of unknown mechanism.
SGTC_1769 st044406 64.4 µM -0.373794235731311 0.341651718603828 no 2222 0.354278704186947 3053 670903
SGTC_2792 7535235 81.82 µM -0.37479837383712 0.341268321947528 no 2223 0.353905211877014 3116 1281891
SGTC_1921 5740136 50 µM -0.374949554020206 0.341210613011781 no 2224 0.353848992099252 3228 1774243
SGTC_1005 4092-0690 4.4 µM -0.376419506265237 0.340649692375776 no 2225 0.353302523335407 3094 1529343
SGTC_371 0195-0006 7.36 µM -0.377546360062607 0.340219933451378 no 2226 0.35288380932514 3002 3928593
SGTC_3036 9090181 49.47 µM -0.378267604270834 0.339944974556556 no 2227 0.352615904337952 3042 25236586
SGTC_2487 5918373 44.05 µM -0.378384577136314 0.339900389176882 no 2228 0.352572461841638 3218 2876279
SGTC_2050 5263056 171 µM -0.37880625599336 0.339739680646319 no 2229 0.352415870696454 3212 763468 YGL055W OLE1
SGTC_2486 5283202 22.39 µM -0.379709651443164 0.339395480323323 no 2230 0.35208047751271 3100 1377751
SGTC_2938 9059746 27.26 µM -0.379931814250088 0.339310855166138 no 2231 0.351998015309282 3177 6471769
SGTC_151 3013-0144 2.285 µM -0.381069486466157 0.338877625779933 no 2232 0.351575844249718 3253 906558 YHR107C CDC12
SGTC_1880 MG-132 525 µM -0.381173267317873 0.33883811627885 no 2233 0.351537342018424 3191 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_179 1273-0063 6.77 µM -0.381505726657409 0.338711560528169 no 2234 0.351414011348394 3069 3108139
SGTC_1054 3429-0080 167 µM -0.382099286424666 0.338485658170901 no 2235 0.351193860543287 3238 1162877
SGTC_1561 5-methoxyflavone 52.9 µM -0.382734402493784 0.338244004292642 no 2236 0.350958351832987 3109 94525
SGTC_362 0310-0100 9.03 µM -0.383712138606615 0.337872117930783 no 2237 0.350595907388627 3190 790235
SGTC_287 k060-0039 29.6 µM -0.38382176202156 0.337830432024658 no 2238 0.350555278720781 3213 5861974
SGTC_945 3381-0768 11.3 µM -0.384232498380415 0.337674261211017 no 2239 0.350403066674734 3230 1126236 YIL048W NEO1
SGTC_2102 5377816 72.7585 µM -0.384762217359007 0.337472891907494 no 2240 0.350206797121781 3257 1379702
SGTC_1344 1488-0097 29.1 µM -0.385679313176561 0.337124373808896 no 2241 0.34986709270571 3186 747966
SGTC_2957 9076800 11.52 µM -0.386414192376649 0.336845203171305 no 2242 0.349594970423542 3108 16459615
SGTC_2358 9037157 4 µM -0.386618464439619 0.336767618940923 no 2243 0.349519343165327 3171 2388925
SGTC_27 0485-0001 32.618 µM -0.38716400720036 0.33656045131195 no 2244 0.349317397186026 3114 2054479
SGTC_1603 st002045 67.8 µM -0.389292328108957 0.33575270484958 no 2245 0.348529955440974 3216 5887985
SGTC_2412 st077135 33.4 µM -0.39005207167123 0.33546454823692 no 2246 0.348249021321101 3315 13258915
SGTC_793 0488-0545 106 µM -0.390398077788024 0.335333346604133 no 2247 0.348121104513552 3061 292548
SGTC_2064 5220758 200 µM -0.392178921832465 0.33465838850891 no 2248 0.34746300857563 3255 788518
SGTC_2479 5617353 43.85 µM -0.392388332644808 0.334579054713189 no 2249 0.347385652727895 3253 2731746
SGTC_1587 estradiol valerate 56.1 µM -0.39521615043903 0.333508480513617 no 2250 0.346341687273437 3236 13791 A steroid.
SGTC_3177 9107506 49.47 µM -0.39602876083075 0.333201087186882 no 2251 0.346041905540916 3178 8897194
SGTC_2543 pimpinellin 60.67 µM -0.396173420708178 0.333146377153701 no 2252 0.345988548884269 3087 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1096 rimcazole 32.2 µM -0.398732194579216 0.332179242523787 no 2253 0.345045271551129 3088 18528119 A dopamine reuptake inhibitor.
SGTC_3245 9134821 49.47 µM -0.399554736598331 0.331868584830006 no 2254 0.344742250203139 3120 17014901
SGTC_1411 3909-8223 150 µM -0.399637431259265 0.331837359097616 no 2255 0.344711791310509 3204 X1411
SGTC_1396 3511-0007 98.6 µM -0.400578302087124 0.331482165973343 no 2256 0.344365311641243 3190 X1396
SGTC_1450 4112-4260 37.6 µM -0.400821061307345 0.331390545230894 no 2257 0.344275935708602 3245 1633175
SGTC_2831 7999036 19.48 µM -0.401653996314529 0.331076260580426 no 2258 0.343969342663629 3312 2988270
SGTC_2845 9003024 42.97 µM -0.401726333950076 0.331048971615859 no 2259 0.343942720914638 3318 2990173
SGTC_237 nikkomycin 200 µM -0.402187102289084 0.330875170431752 no 2260 0.343773166779694 3250 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1511 0906-3109 28.5 µM -0.403735609087365 0.330291343036903 no 2261 0.34320357561665 3113 2882180
SGTC_2796 7949634 45.45 µM -0.404727689399171 0.329917519822266 no 2262 0.34283884323531 3082 2971588
SGTC_1292 0kpi-0043 232 µM -0.405009438218751 0.329811385719976 no 2263 0.342735286653202 3156 3333905
SGTC_1758 st042942 75.2445 µM -0.406068075901211 0.329412721966327 no 2264 0.342346290777468 3195 669317
SGTC_952 1185-0122 232 µM -0.409483769435295 0.328127757209191 no 2265 0.341092337707796 3092 678600
SGTC_1294 1000-1494 117 µM -0.410884920966471 0.327601238488195 no 2266 0.340578459904703 3152 712797 YDL207W GLE1
SGTC_2624 nerol 100 µM -0.410975755826313 0.327567116769477 no 2267 0.340545156064029 3112 637566 A natural product oil.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.41121818896139 0.327476054872033 no 2268 0.340456276072935 3285 16725076
SGTC_1145 3546-0597 10.2 µM -0.411990914403547 0.327185874921591 no 2269 0.340173041313232 3163 875334
SGTC_112 phenothiazine 287.218 µM -0.412067066379949 0.327157283380827 no 2270 0.340145133448052 3268 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_270 tamoxifen 5.46 µM -0.412272020411596 0.327080337671464 no 2271 0.340070027082423 3326 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1663 st014140 55.4 µM -0.414872436294355 0.326104704998225 no 2272 0.339117644424792 3197 4207120
SGTC_1632 st005650 90 µM -0.41506334105915 0.326033127486882 no 2273 0.339047767394907 3213 2759605
SGTC_905 2-aminofluorene 215 µM -0.418502086375272 0.324744909840238 no 2274 0.337790030720412 3139 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.419383579341433 0.324415022726315 no 2275 0.337467911439711 3221 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1046 2001-0062 216 µM -0.422814971482162 0.323132183166187 no 2276 0.336215131775214 3129 739778
SGTC_2018 5133068 143 µM -0.42284238947576 0.323121941280613 no 2277 0.336205128936554 3115 785362
SGTC_1428 4049-0204 61.7 µM -0.423138351037921 0.323011394519588 no 2278 0.336097161396654 3256 X1428
SGTC_299 1273-0059 1.44 µM -0.424036121329999 0.322676157455376 no 2279 0.335769735224207 3242 2848077
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.424645192265537 0.322448805841529 no 2280 0.335547671653091 3219 6708739 YPR165W RHO1
SGTC_1235 benzylparaben 21.5 µM -0.424668470578524 0.322440117920575 no 2281 0.335539185660204 3223 7180
SGTC_2493 resveratrol 26.09 µM -0.424830285986362 0.32237972793076 no 2282 0.335480198978978 3103 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3171 9103192 49.47 µM -0.425659487115637 0.322070341188329 no 2283 0.335177993379412 3266 13018434
SGTC_2773 thioridazine 9.09 µM -0.425985032822711 0.32194890913688 no 2284 0.335059376115809 3216 5452 An antipsychotic.
SGTC_2124 5246320 200 µM -0.427301507363047 0.321458043950927 no 2285 0.334579867526308 3238 579342
SGTC_2721 ifenprodil 61.44 µM -0.430228702693112 0.320367717631195 no 2286 0.333514642406284 3289 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2683 piperine 63.03 µM -0.430796432244538 0.320156427869873 no 2287 0.333308196982895 3173 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2988 9073640 71.4286 µM -0.431102824696967 0.320042423168611 no 2288 0.333196803427257 3341 9102229
SGTC_806 3966-4455 5.86 µM -0.431198547786509 0.320006809317707 no 2289 0.33316200488319 3153 714982
SGTC_1489 4065-0444 182 µM -0.43247420564006 0.319532358252396 no 2290 0.332698397808534 3273 2877968
SGTC_3184 9108758 49.47 µM -0.43275443162202 0.31942817428691 no 2291 0.332596590667852 3173 902885
SGTC_3208 9114115 49.47 µM -0.432762401679384 0.319425211343322 no 2292 0.332593695296914 3220 650895
SGTC_2032 5185112 25.99 µM -0.434079488382363 0.318935730511008 no 2293 0.332115359933508 3187 5718189
SGTC_2037 5169046 200 µM -0.435024265378505 0.318584808835752 no 2294 0.331772407182161 3271 5718022
SGTC_205 1486-1330 71.903 µM -0.435620635794627 0.318363380700408 no 2295 0.331555998078586 3174 4118834
SGTC_848 0368-0089 85.6 µM -0.435651969450249 0.318351748527945 no 2296 0.331544629369641 3276 762535
SGTC_420 mitomycin C 81.9 mM -0.438460161435687 0.317309975752676 no 2297 0.330526371645196 3166 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1659 st012954 42.1 µM -0.43899913776511 0.31711019340479 no 2298 0.330331080546643 3270 24207262
SGTC_1504 k297-0033 30 µM -0.442383223382147 0.315857034155505 no 2299 0.329105958503675 3115 4388117
SGTC_2614 arthonioic acid 13.39 µM -0.44323916186176 0.315540406278186 no 2300 0.328796377720467 3230 6710684
SGTC_1588 farnesol 29.9 µM -0.444160541704962 0.315199721688748 no 2301 0.328463258969761 3180 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_336 4111-0029 111 µM -0.446607427831643 0.314295737083784 no 2302 0.327579265790941 3207 3131175
SGTC_2606 farnesol 9.78 µM -0.449667605738768 0.313166742331429 no 2303 0.326475066341963 3333 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1753 st043925 64 µM -0.450039915586274 0.313029504798953 no 2304 0.326340829772091 3272 670181
SGTC_472 calcifediol 10 µM -0.450132894040612 0.31299523595215 no 2305 0.326307309835862 3241 5283731 A vitamin D metabolite.
SGTC_455 paf C-16 10 µM -0.450288428292397 0.312937914676201 no 2306 0.326251240861249 3189 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2011 4012611 177 µM -0.450908621739617 0.312709390836019 no 2307 0.326027704659002 3167 2049887
SGTC_921 1561-0023 372 µM -0.451332282336311 0.312553325192507 no 2308 0.325875040680856 3168 24050882
SGTC_1930 st074634 34.3 µM -0.451649132847999 0.312436627595964 no 2309 0.325760884259548 3160 684253 YOR116C RPO31
SGTC_2904 7225135 42.03 µM -0.451797466933114 0.312382001888065 no 2310 0.325707447357446 3313 4446116
SGTC_139 0099-0334 718.624 µM -0.452518113630032 0.312116674264362 no 2311 0.325447887558549 3231 97690
SGTC_1558 st069300 45.6 µM -0.452518371641444 0.312116579287189 no 2312 0.325447794644125 3292 24208000
SGTC_293 4049-0273 38.5 µM -0.453520078399413 0.311747932904445 no 2313 0.32508714433844 3215 1380311
SGTC_2467 5474540 200 µM -0.455077335611843 0.311175208309533 no 2314 0.324526801344926 3177 5413519
SGTC_1682 st012968 530 nM -0.455545957197295 0.311002949070116 no 2315 0.324358256357713 3175 24207270
SGTC_3057 9095946 49.47 µM -0.456339441486707 0.31071136890893 no 2316 0.324072952918138 3242 24540043
SGTC_678 1218-2179 85.9 µM -0.456465203171878 0.310665166408433 no 2317 0.324027743806346 3265 6820081 YOR116C RPO31
SGTC_1966 st070145 16.1 µM -0.456675407177078 0.310587948039089 no 2318 0.323952184961391 3141 3748532
SGTC_416 estradiol valerate 100 µM -0.456870209939756 0.310516394760746 no 2319 0.323882168642671 3269 13791 A steroid.
SGTC_795 0685-0265 78 µM -0.457454536121614 0.310301808095456 no 2320 0.323672186583327 3312 302754
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.457769095068695 0.310186316886225 no 2321 0.323559170666426 3184 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1790 st045711 43.5 µM -0.459686175039791 0.309482860561487 no 2322 0.322870747109706 3370 585119
SGTC_2347 9049783 174.81 µM -0.46045490878368 0.309200975971116 no 2323 0.322594864990997 3335 6467988 YPL169C MEX67
SGTC_2419 paclitaxel 166.5 µM -0.461030751798885 0.308989895424906 no 2324 0.322388271188512 3223 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_572 0960-0087 17.7 µM -0.462195093540266 0.308563287968544 no 2325 0.321970710725826 3247 6796365
SGTC_1702 st027038 51 µM -0.462554767310889 0.308431557961755 no 2326 0.321841768608301 3271 5521182
SGTC_2719 novobiocin 32.65 µM -0.46267815370316 0.308386373550876 no 2327 0.321797539846206 3329 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1002 4049-0206 172 µM -0.462940559200568 0.308290289640497 no 2328 0.321703487056084 3217 4662749
SGTC_2066 5222451 176 µM -0.464903172570633 0.307572064608003 no 2329 0.321000399234382 3224 2281147
SGTC_669 0108-0021 26.2 µM -0.464978879567586 0.307544374121489 no 2330 0.320973290744084 3509 17201
SGTC_2348 9022543 33.42 µM -0.465479182817236 0.307361411471206 no 2331 0.320794170587447 3303 3162678 YDL140C RPO21
SGTC_1167 k781-0610 148 µM -0.4673257907581 0.306686515679622 no 2332 0.320133403505592 3228 4525169
SGTC_2986 9022445 71.43 µM -0.467719631528527 0.306542659938083 no 2333 0.319992550136935 3333 6459286
SGTC_2429 5902844 64.44 µM -0.467951819991622 0.306457863881308 no 2334 0.3199095223184 3312 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1805 st050013 60.3 µM -0.4689642962021 0.306088225105499 no 2335 0.319547578406529 3239 4037144
SGTC_1400 3771-8998 51.5 µM -0.469014272156764 0.306069984796611 no 2336 0.319529717256308 3224 670767
SGTC_1996 st072960 66.8 µM -0.469134981292259 0.306025930154451 no 2337 0.319486578156394 3346 1719405
SGTC_1866 st057638 64 µM -0.469227066770502 0.305992324039605 no 2338 0.319453670238085 3237 688802
SGTC_840 0245-0196 390 µM -0.46943036353523 0.305918137728527 no 2339 0.319381024585278 3369 3827528
SGTC_422 cantharidin 155 µM -0.46983325201677 0.305771140664904 no 2340 0.319237077719044 3176 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1223 0764-0573 147 µM -0.469834003831351 0.305770866388622 no 2341 0.319236809130838 3258 1609797
SGTC_604 1000-0114 314 µM -0.470403712852897 0.305563057015733 no 2342 0.319033306012612 3353 1572745
SGTC_1057 3448-5381 134 µM -0.471316601846807 0.305230198503483 no 2343 0.318707330884215 3311 5497911
SGTC_412 gemfibrozil 100 µM -0.471490560531322 0.305166787767415 no 2344 0.318645229478603 3310 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1171 0368-0077 21.4 µM -0.471658931246454 0.305105419505033 no 2345 0.318585127769341 3210 3239779
SGTC_1486 3970-0793 4.53 µM -0.472413389328718 0.30483049967214 no 2346 0.318315874596558 3333 2844330
SGTC_1868 st057644 42.7 µM -0.473183337671773 0.30455004884882 no 2347 0.318041192140014 3204 688665
SGTC_2968 9090663 33.37 µM -0.473584158267324 0.304404096884628 no 2348 0.317898237223741 3228 25236811
SGTC_3147 9097027 49.47 µM -0.473597961680185 0.304399071162552 no 2349 0.317893314642226 3218 25236841
SGTC_226 1,3-diallylurea 8.28947 mM -0.474677700586214 0.304006060599703 no 2350 0.317508357262982 3295 74537 YKL182W FAS1
SGTC_2316 5844804 197.44 µM -0.477657305959282 0.302922699353732 no 2351 0.316447068162496 3312 776813
SGTC_90 0870-0863 4.608 µM -0.478322320821671 0.302681141224792 no 2352 0.316210405985301 3224 1738164
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.47903921248791 0.302420836215785 no 2353 0.315955366456467 3263 4620898
SGTC_1036 k216-0215 33.5 µM -0.480644201358591 0.301838425376753 no 2354 0.31538469740117 3294 622330
SGTC_2055 5235184 200 µM -0.481378539443835 0.301572120399042 no 2355 0.315123743175997 3364 2836034
SGTC_309 k408-0051 1.48 µM -0.481548486990334 0.30151050461727 no 2356 0.315063363790436 3320 3640463
SGTC_1811 st050069 61.5 µM -0.481723905667923 0.301446911176877 no 2357 0.315001045790166 3341 3877702
SGTC_3216 9129716 49.47 µM -0.482106598186356 0.30130819699705 no 2358 0.314865111426396 3231 8056934
SGTC_2825 7998094 58.44 µM -0.483393535238026 0.300841933191735 no 2359 0.314408168774004 3264 2987815
SGTC_340 k038-0059 454 µM -0.483562036573424 0.300780908409224 no 2360 0.314348361352652 3326 23733424
SGTC_2556 citropten 84.59 µM -0.487660518525025 0.299298317384455 no 2361 0.312895160766168 3265 2775 A potential DNA crosslinker.
SGTC_2497 7-hydroxyflavone 100 µM -0.488261822029355 0.299081080100799 no 2362 0.312682199945254 3365 5281894
SGTC_2328 6201408 200 µM -0.490615558232101 0.29823141809084 no 2363 0.311849190156174 3353 2890418
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.491825251868344 0.297795165660141 no 2364 0.311421441791058 3302 2333 A French combination drug.
SGTC_3348 9149464 3.537 µM -0.49271809611355 0.297473365601353 no 2365 0.31110589471263 3328 1951442
SGTC_3078 9116413 49.47 µM -0.494503722260281 0.296830264780478 no 2366 0.310475239110458 3250 17177322
SGTC_2662 daunorubicin 22.37 µM -0.494704197833763 0.296758102402759 no 2367 0.310404468957871 3281 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1974 st069448 26.9 µM -0.494757714799502 0.296738840010211 no 2368 0.310385578048373 3364 6323587 YNR016C ACC1
SGTC_865 0488-0499 301 µM -0.498005908345629 0.295570789229177 no 2369 0.309239938894884 3413 9634651
SGTC_1391 3442-0225 151 µM -0.499185585597565 0.295147101040801 no 2370 0.308824324153585 3265 5227075
SGTC_982 1491-0518 27.5 µM -0.499271189613424 0.295116366728934 no 2371 0.308794174327002 3265 3091256
SGTC_639 0833-0042 114 µM -0.499654616271969 0.294978723582563 no 2372 0.308659146858703 3264 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_115 0527-0192 112.043 µM -0.49969477593535 0.294964308710467 no 2373 0.308645005734546 3371 4233931
SGTC_2473 5854593 8.94 µM -0.50123658223327 0.294411139796337 no 2374 0.308102315670036 3203 2872951
SGTC_2154 5570129 200 µM -0.503380710388246 0.293642667122947 no 2375 0.307348315472739 3376 673366
SGTC_1357 1503-1303 39.5 µM -0.504182520160155 0.293355530823642 no 2376 0.307066561324351 3312 292895
SGTC_3153 9100258 49.47 µM -0.504332702489465 0.293301763462153 no 2377 0.307013800250482 3267 25236848
SGTC_615 k087-0205 167 µM -0.504597051005464 0.293207134115621 no 2378 0.306920940766319 3292 9642773
SGTC_1193 1488-0126 41.5 µM -0.504891143775747 0.293101873797696 no 2379 0.306817647372266 3309 1384710
SGTC_82 0054-0107 293.755 µM -0.504960335928328 0.293077111410913 no 2380 0.306793347431337 3323 3104697
SGTC_2324 6149169 200 µM -0.505151911127156 0.293008555820969 no 2381 0.306726071601172 3280 2888231
SGTC_3275 9138069 49.47 µM -0.505840769001847 0.292762108069265 no 2382 0.306484217864568 3370 17617007
SGTC_3081 9117243 49.47 µM -0.507193046354068 0.292278593626219 no 2383 0.306009686792836 3424 45595589
SGTC_1990 st072050 59.8 µM -0.507531225739425 0.292157733751945 no 2384 0.305891066239009 3270 17233948
SGTC_2297 7971671 152.32 µM -0.508870172691966 0.291679444108675 no 2385 0.305421614188904 3418 909016
SGTC_2030 5175110 200 µM -0.510253842951051 0.291185562503098 no 2386 0.304936817529766 3413 2831986
SGTC_1180 1193-0155 285 µM -0.511121780947864 0.290875963675079 no 2387 0.304632892608063 3387 2921347
SGTC_2691 st077356 60.2 µM -0.512408607642485 0.290417228046573 no 2388 0.304182534010481 3428 2839272
SGTC_1041 0206-0046 107 µM -0.512524976438927 0.290375760910805 no 2389 0.304141822340321 3322 50494
SGTC_1395 3486-0190 4.35 µM -0.513453130122492 0.290045119682045 no 2390 0.303817194349753 3447 6748079
SGTC_2400 5203494 178.7 µM -0.513536427044426 0.290015454998943 no 2391 0.303788068251492 3371 6777674
SGTC_200 k038-0079 37.545 µM -0.514039487579618 0.289836329384235 no 2392 0.303612191594353 3292 3436683
SGTC_3268 9137683 49.47 µM -0.514574939250459 0.289645727240859 no 2393 0.303425040526835 3276 1953228
SGTC_2427 5545055 42.75 µM -0.517096445887254 0.288748950571801 no 2394 0.302544417259509 3327 5372858
SGTC_2840 9008771 71.43 µM -0.517295748509364 0.288678124155717 no 2395 0.302474860719452 3325 2992978
SGTC_244 nsc-207895 1.295 µM -0.517386273696653 0.288645956811784 no 2396 0.302443269831274 3287 42640
SGTC_1915 st067105 30.6 µM -0.517679171811997 0.288541889564791 no 2397 0.302341066300592 3394 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_680 0417-1641 114 µM -0.518425192987794 0.288276906737713 no 2398 0.302080820543653 3248 2835990
SGTC_2003 4023581 200 µM -0.518964275650457 0.288085498846464 no 2399 0.301892826878475 3403 16641307
SGTC_326 k292-0812 17.5 µM -0.519570079191771 0.287870472487854 no 2400 0.301681628473604 3361 3579357
SGTC_2184 6075246 200 µM -0.520109238231849 0.287679164968119 no 2401 0.30149371992234 3367 2267320
SGTC_140 0062-0056 502.533 µM -0.521552751142988 0.287167265369986 no 2402 0.300990884017273 3291 3758964
SGTC_2788 5282734 71.43 µM -0.521669168744273 0.287126000072938 no 2403 0.300950347379268 3436 743706
SGTC_369 0957-0393 4.5 µM -0.5224399666331 0.286852854477057 no 2404 0.300682017488142 3347 6997992
SGTC_2468 5987765 72.9 µM -0.522798176870756 0.286725958392899 no 2405 0.300557354227679 3341 26772094
SGTC_1884 5633444 25 µM -0.523405761969374 0.286510782064428 no 2406 0.300345957653935 3421 5724239
SGTC_2104 5389443 200 µM -0.523934372576863 0.286323636906532 no 2407 0.300162093285491 3466 2244536
SGTC_1968 st069590 43.6 µM -0.524061690227665 0.286278571036462 no 2408 0.300117816538131 3382 6384066
SGTC_2198 6589944 200 µM -0.526059420525642 0.285571887754281 no 2409 0.299423461079895 3374 5290268
SGTC_2867 9039098 71.43 µM -0.526208606341832 0.285519147637113 no 2410 0.299371637483024 3360 6463460
SGTC_3191 9110352 49.47 µM -0.527142281111974 0.285189180619786 no 2411 0.299047393555655 3392 17122424
SGTC_193 1273-0060 1.558 µM -0.527380795025908 0.28510491733033 no 2412 0.298964588696237 3366 2847393 YHR072W ERG7
SGTC_1867 st057372 64 µM -0.527958861868693 0.28490074447764 no 2413 0.2987639444863 3410 688837
SGTC_1477 0139-0234 16 µM -0.528264114856869 0.284792957457379 no 2414 0.298658017346844 3393 620880
SGTC_3022 9087993 49.47 µM -0.529328769159159 0.284417172756238 no 2415 0.298288700839122 3407 17173644
SGTC_2618 avocadyne 43.43 µM -0.53002332740724 0.284172146421319 no 2416 0.298047878585756 3348 3015189
SGTC_2284 7945075 39.21 µM -0.530415500295276 0.284033840229161 no 2417 0.297911940717233 3401 1245402
SGTC_1700 st030840 7.9285 µM -0.530636443418794 0.283955935202421 no 2418 0.297835368227477 3408 5499307
SGTC_2160 5660466 132.927 µM -0.531380451422959 0.283693671575828 no 2419 0.297577582620778 3399 2859134
SGTC_363 0455-0021 3.06 µM -0.531967024796954 0.283486985648799 no 2420 0.29737441715696 3404 4597466
SGTC_616 4092-0450 108 µM -0.532271414455716 0.283379758874721 no 2421 0.297269013778957 3388 787165
SGTC_310 1273-0058 1.06 µM -0.532989250952189 0.283126964987496 no 2422 0.297020510575138 3428 2734232
SGTC_2163 5671233 125 µM -0.534235127324095 0.282688473205464 no 2423 0.296589434358687 3506 701023
SGTC_320 4092-0846 5.34 µM -0.534454280213436 0.282611375126543 no 2424 0.296513636583189 3374 1359356
SGTC_6 0844-0013 19.835 µM -0.534455129038713 0.282611076529103 no 2425 0.296513343019705 3478 1584900
SGTC_861 0443-0273 110 µM -0.535818764146509 0.28213157660477 no 2426 0.296041906281348 3391 6149169
SGTC_1706 st031321 9.9705 µM -0.536343599459034 0.281947131312409 no 2427 0.295860551638892 3420 6103185
SGTC_1444 4112-3581 28 µM -0.536957168737743 0.281731575509309 no 2428 0.295648600065802 3428 2877249
SGTC_698 k064-0052 127 µM -0.537229780976799 0.281635828364911 no 2429 0.295554451202669 3457 5088751
SGTC_1043 0916-0009 19.3 µM -0.537537974963082 0.281527603064019 no 2430 0.295448030497212 3473 3101130
SGTC_2 0422-0095 29 µM -0.539489793956852 0.280842669172577 no 2431 0.294774468673514 3343 6790840
SGTC_312 4092-0653 6.84 µM -0.539491848946745 0.28084194845864 no 2432 0.294773759881238 3405 1148278
SGTC_3071 9117417 49.47 µM -0.539761115316873 0.280747520680869 no 2433 0.294680893267037 3310 45595590 YGL055W OLE1
SGTC_3105 9121040 49.47 µM -0.539930145891811 0.280688251976293 no 2434 0.294622603623957 3352 41448907
SGTC_2638 epoxomicin 18 µM -0.542101753183053 0.279927340711914 no 2435 0.293874205521779 3401 9915668 A protesome inhibitor.
SGTC_1376 2910-0861 41.3 µM -0.543529343915045 0.279427671538095 no 2436 0.293382696376348 3407 1112859
SGTC_1313 1220-0047 237 µM -0.544424454568176 0.279114596146422 no 2437 0.293074710675754 3394 3528706
SGTC_746 1095-0025 46.6 µM -0.544605095678288 0.279051435499036 no 2438 0.293012574675109 3466 6749286
SGTC_538 2922-0838 53.3 µM -0.54622957899289 0.278483752067047 no 2439 0.292454068074122 3482 777039
SGTC_2882 9058044 58.44 µM -0.547524215773697 0.278031738319237 no 2440 0.292009319240476 3400 18076804
SGTC_7 0192-1582 4.227 µM -0.547618224409525 0.277998929780011 no 2441 0.291977036556245 3439 252616
SGTC_1030 k029-0042 36.7 µM -0.548242350593242 0.277781160809909 no 2442 0.291762752988482 3398 6080581
SGTC_1188 1403-0014 4.57 µM -0.548770882840061 0.277596811463006 no 2443 0.291581347367557 3384 9614867
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.55051922869596 0.27698742361376 no 2444 0.290981645929006 3457 6708760
SGTC_1430 4049-0248 69.1 µM -0.551979110014003 0.276479082620506 no 2445 0.290481332878254 3472 22774488
SGTC_2601 securinine 100 µM -0.553669932000875 0.275890898764032 no 2446 0.289902378325985 3335 442872 A GABA receptor antagonist.
SGTC_2583 asiatic acid 100 µM -0.553762217849989 0.275858813115949 no 2447 0.289870794298406 3491 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1529 apigenin 74 µM -0.554344633430252 0.275656363039474 no 2448 0.28967150488516 3532 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2109 5483026 200 µM -0.555149403802209 0.275376741765439 no 2449 0.289396236572256 3407 759335
SGTC_1432 4049-0298 68.4 µM -0.5561256841822 0.275037715993293 no 2450 0.289062469046844 3458 741646
SGTC_2515 chrysin 20.77 µM -0.559431622300033 0.273891216137464 no 2451 0.287933592512048 3427 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2607 solasodine 47.35 µM -0.559683159874802 0.273804079688372 no 2452 0.287847785424455 3391 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2839 9003951 25.97 µM -0.560201276597242 0.273624639371892 no 2453 0.287671078182137 3456 2990634
SGTC_272 doxorubicin 8.13 µM -0.560865119700256 0.273394814440156 no 2454 0.287444744913736 3446 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_845 0330-0138 4.51 µM -0.561261523943861 0.273257623422045 no 2455 0.287309633470341 3418 9039800
SGTC_351 caspofungin 25 nM -0.561765798891684 0.273083148875062 no 2456 0.287137798539038 3438 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2310 7668677 200 µM -0.563373739785669 0.272527184935391 no 2457 0.286590207509391 3539 2197143
SGTC_975 1335-0046 28.5 µM -0.563729537913883 0.272404239643823 no 2458 0.286469105922698 3400 16486740
SGTC_2693 st077581 40.7 µM -0.564136172879069 0.272263761533117 no 2459 0.286330730946231 3470 25238761
SGTC_2431 5490079 200 µM -0.564977606056304 0.271973190259985 no 2460 0.28604449804845 3413 5722345
SGTC_2357 9067248 200 µM -0.565438006884728 0.271814265815262 no 2461 0.285887939663882 3447 9150235
SGTC_3181 9108277 49.47 µM -0.565664325315243 0.271736160548286 no 2462 0.28581099547058 3378 17097298
SGTC_2531 methyl deoxycholate 70.07 µM -0.567489789170143 0.271106579297843 no 2463 0.285190730975267 3358 16667744 Haematoxylin.
SGTC_1607 st000305 50.6 µM -0.568113105880106 0.270891771338955 no 2464 0.284979084573441 3467 5457690
SGTC_285 1486-1325 46 µM -0.569278025949396 0.270490543384594 no 2465 0.284583738364722 3497 22310230
SGTC_2094 5332512 191.667 µM -0.569358177464131 0.270462948096242 no 2466 0.284556546476715 3488 755774
SGTC_457 grayanotoxin iii 135 µM -0.56993416472702 0.270264683380858 no 2467 0.284361175806958 3461 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_59 0330-0160 1.33 µM -0.570156866558393 0.270188045068259 no 2468 0.28428565416088 3478 4293482
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.571658384739514 0.269671611925652 no 2469 0.283776716446249 3429 15053
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.571857284621449 0.26960323927661 no 2470 0.283709332315108 3495 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3070 9117005 49.47 µM -0.573543500739555 0.269023944739326 no 2471 0.283138377067241 3508 8779016
SGTC_2115 tiliquinol 12.7705 µM -0.573709283864434 0.268967024188751 no 2472 0.283082272439246 3416 71208 A bioactive hydroxyquinoline.
SGTC_1835 st008666 49.2 µM -0.57471144562682 0.268623067297561 no 2473 0.282743232683064 3369 690455
SGTC_318 1488-0629 67.2 µM -0.574957847074679 0.268538532506674 no 2474 0.282659902890632 3468 3662576
SGTC_2820 7989630 71.43 µM -0.57500083060075 0.268523787196283 no 2475 0.282645367625506 3402 2984098
SGTC_76 0433-0009 400.328 µM -0.575204158797599 0.268454041865516 no 2476 0.282576615240103 3472 2841569
SGTC_2047 4141938 200 µM -0.577896353490255 0.26753142887556 no 2477 0.281667048681251 3423 3807862
SGTC_884 0851-0618 334 µM -0.578310027061606 0.267389805104845 no 2478 0.281527412965574 3490 9642473
SGTC_2650 prasterone 100 µM -0.578874845475875 0.267196497026695 no 2479 0.281336812174222 3452 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_222 nsc-310342 10.666 µM -0.579546524393712 0.266966707987527 no 2480 0.281110231882479 3468 432556
SGTC_2414 st077232 92.9 µM -0.579672839052593 0.266923505451192 no 2481 0.281067631473172 3331 729801
SGTC_1993 st073995 70.8 µM -0.579692957628373 0.266916624758779 no 2482 0.281060846645518 3440 3098394
SGTC_483 fpl-64176 144 µM -0.579889900291034 0.266849273734485 no 2483 0.280994433497509 3495 3423
SGTC_507 nimesulide 162 µM -0.582116298405043 0.26608848134522 no 2484 0.280244173813189 3550 4495 A COX2 inhibitor.
SGTC_2540 epiandrosterone 100 µM -0.582218406145593 0.266053616017854 no 2485 0.280209788463615 3567 441302 A steroid.
SGTC_215 1287-0124 461.5 µM -0.582415253186263 0.265986407893834 no 2486 0.280143504896862 3441 5560863
SGTC_1852 st056254 31.4 µM -0.582724572020215 0.265880816681371 no 2487 0.280039364476665 3400 442583
SGTC_2857 9024691 58.44 µM -0.58297425843661 0.265795597498955 no 2488 0.279955314587534 3476 16478292
SGTC_1636 st007707 68.9 µM -0.583635729589609 0.265569901135286 no 2489 0.279732708124908 3555 403051
SGTC_642 0335-0876 158 µM -0.584517332928107 0.265269246057836 no 2490 0.279436153636517 3499 6812350
SGTC_1339 1486-1321 22.7 µM -0.584758567890669 0.265187007302674 no 2491 0.279355033428383 3431 3469382
SGTC_3281 9140613 49.47 µM -0.58511319494431 0.26506613586805 no 2492 0.279235803576946 3435 16013766
SGTC_3336 9143619 71.43 µM -0.585247052161815 0.265020519118735 no 2493 0.27919080561185 3527 45595730
SGTC_2063 5246145 200 µM -0.585558850802878 0.264914277780224 no 2494 0.279086003832048 3506 711240
SGTC_1208 2323-2347 50.3 µM -0.586765691358447 0.264503266658173 no 2495 0.27868054090847 3498 5412760
SGTC_819 1013-0258 27.7 µM -0.587668671328907 0.264195953048697 no 2496 0.27837735389916 3477 5753198
SGTC_174 3553-0389 74.3 µM -0.588256586788894 0.263995963985014 no 2497 0.278180040249516 3516 738071
SGTC_641 4092-0595 30 µM -0.590573251609807 0.263208664213538 no 2498 0.277403195750372 3520 786260
SGTC_2861 9024595 19.48 µM -0.590945043637497 0.263082425482551 no 2499 0.277278622000325 3429 16482810
SGTC_2797 7859098 81.82 µM -0.592212105964594 0.26265243806843 no 2500 0.276854281928478 3466 972681
SGTC_2119 5528445 120.635 µM -0.592469099456417 0.262565269220614 no 2501 0.27676825343756 3520 791935
SGTC_1200 1643-0193 18.4 µM -0.592708635239659 0.262484035133983 no 2502 0.276688080702423 3523 5403974
SGTC_2069 5228469 200 µM -0.594203931683417 0.261977224279596 no 2503 0.276187861712411 3476 2835210
SGTC_2396 5342950 42.78 µM -0.595195225643787 0.261641515128586 no 2504 0.275856490655195 3485 1886677
SGTC_1994 st072947 40.9 µM -0.595787311123186 0.261441106296011 no 2505 0.275658660759787 3535 5286565 YDL195W SEC31
SGTC_1672 st016598 6.51 µM -0.597564745500657 0.260839954952467 no 2506 0.275065196802453 3447 4665860 YNL267W PIK1
SGTC_1873 rapamycin 2 nM -0.598070960402436 0.260668876697199 no 2507 0.274896292946479 3513 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1199 1638-0010 4.46 µM -0.598652849141807 0.260472295398958 no 2508 0.274702202895205 3453 3111136
SGTC_1618 st003135 44.5 µM -0.599871472792299 0.260060851450609 no 2509 0.274295947829131 3470 1270615
SGTC_656 4090-1979 187 µM -0.600315483013288 0.259911023595296 no 2510 0.274148000999074 3550 22330961
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.600336092680896 0.25990407010198 no 2511 0.274141134693441 3452 4174840
SGTC_2181 6316240 54.2555 µM -0.601297861971899 0.259579685632377 no 2512 0.273820806677147 3504 12779990
SGTC_2019 4016004 108 µM -0.602404886980244 0.259206568423237 no 2513 0.2734523288942 3470 45595336
SGTC_3012 9080433 71.4286 µM -0.602645321876263 0.259125567708773 no 2514 0.273372331619744 3535 17688859
SGTC_1718 roemerine 11.9335 µM -0.602663192193948 0.259119547855196 no 2515 0.273366386287014 3514 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1707 st032323 6.317 µM -0.602670936890174 0.25911693897399 no 2516 0.273363809699324 3468 3132057 YMR211W DML1
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.603503479573229 0.258836567558732 no 2517 0.273086900722259 3501 688667
SGTC_2589 lobaric acid 100 µM -0.603684547352431 0.258775611018465 no 2518 0.273026694841698 3459 73157 A novel microtubule depolymerizer.
SGTC_2850 9015429 58.44 µM -0.603743721529944 0.258755691618787 no 2519 0.273007020578506 3470 6457570
SGTC_1488 4013-0813 75.9 µM -0.604686525485082 0.258438429036044 no 2520 0.272693651440063 3492 2910057
SGTC_1027 k015-0025 8.67 µM -0.605961048641911 0.258009860322011 no 2521 0.272270309435703 3515 3598955
SGTC_888 0916-0002 6.97 µM -0.606805600937331 0.25772607598545 no 2522 0.271989965346488 3571 2802138 YIL048W NEO1
SGTC_1910 st062352 60.4 µM -0.610197769387111 0.256587882613356 no 2523 0.270865403610157 3488 2245730
SGTC_1705 st027868 56.3335 µM -0.612362499341105 0.255862909378549 no 2524 0.27014897361166 3548 292948
SGTC_387 norethindrone acetate 66.7 µM -0.61261528273785 0.255778321376599 no 2525 0.270065375316506 3502 541197
SGTC_2014 4013930 200 µM -0.613664037380546 0.25542753635512 no 2526 0.269718678731903 3536 64556
SGTC_1051 3253-3903 78 µM -0.614028736493038 0.255305611578267 no 2527 0.269598169009412 3493 5509239
SGTC_747 3448-8087 38.7 µM -0.614456679953121 0.255162582002903 no 2528 0.269456795485423 3514 5168703
SGTC_687 k029-0044 34.9 µM -0.616159814813727 0.254593766577805 no 2529 0.268894523810969 3560 5829338
SGTC_852 0418-0143 439 µM -0.616570016067374 0.254456866292109 no 2530 0.268759188361163 3574 5369229
SGTC_3231 9132313 49.47 µM -0.616983811662926 0.254318805526121 no 2531 0.268622701725447 3511 4905967
SGTC_1736 st036774 51 µM -0.617181221683384 0.254252954529123 no 2532 0.26855760013775 3596 1272247
SGTC_2380 9035439 200 µM -0.61721887063586 0.254240396804597 no 2533 0.268545185221793 3616 6462575
SGTC_2596 sinensetin 100 µM -0.617236864234105 0.254234395194702 no 2534 0.268539251851557 3475 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2499 avocadenofuran 51.48 µM -0.617686267651821 0.25408452465115 no 2535 0.268391082922756 3435 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_709 3807-1509 243 µM -0.618100400521422 0.253946457446305 no 2536 0.268254579151892 3587 1886677 YPL242C IQG1
SGTC_1375 2910-0797 186 µM -0.619311759602435 0.253542830175893 no 2537 0.26785549949511 3502 742508
SGTC_2933 9026794 32.47 µM -0.620000189242034 0.253313594334034 no 2538 0.267628831173544 3503 17586027
SGTC_527 4476-4215 268 µM -0.620430209515369 0.253170459902565 no 2539 0.267487294286328 3445 4418754
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.620448706810813 0.253164303938184 no 2540 0.26748120693275 3471 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2569 tetrandrine 100 µM -0.620478026308594 0.253154546468444 no 2541 0.267471558197735 3473 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2201 6605497 169.863 µM -0.620655662082748 0.253095433870675 no 2542 0.267413103906452 3535 670741
SGTC_192 3455-0609 60.9 µM -0.62191037933779 0.252678103236236 no 2543 0.267000399892824 3600 3769639
SGTC_344 k064-0035 6.43 µM -0.622862416032945 0.252361688959935 no 2544 0.266687468927223 3488 5088750
SGTC_823 0417-1665 178 µM -0.623570039353492 0.252126642107297 no 2545 0.266454995915474 3551 3429856
SGTC_1679 SEC14.276 6.7 µM -0.625008195185151 0.251649294863479 no 2546 0.265982839715691 3540 1005053 YMR079W SEC14
SGTC_2833 9001315 45.46 µM -0.625117648203797 0.25161298518883 no 2547 0.265946922919657 3473 2989378
SGTC_1169 aniline yellow 25.8 µM -0.627168372200691 0.250933195056029 no 2548 0.26527443644136 3520 6051 A DNA damaging agent.
SGTC_2779 methotrexate 400 µM -0.628786253693813 0.250397573684902 no 2549 0.264744500305943 3620 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1722 st034304 3.6505 µM -0.62998930903059 0.249999679274407 no 2550 0.264350789496106 3544 4036148 YLR033W RSC58
SGTC_2639 lactacystin 53 µM -0.630288331029892 0.249900833844712 no 2551 0.264252978095072 3581 3870 A proteasome inhibitor.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.631304293247374 0.249565149966307 no 2552 0.263920790157052 3521 1241132 A phosphatase inhibitor.
SGTC_3182 9108849 49.47 µM -0.632544700697234 0.249155632197046 no 2553 0.26351550442217 3592 17133045
SGTC_1162 k048-0130 20.1 µM -0.633330562973825 0.248896366580342 no 2554 0.263258899410018 3558 6797406
SGTC_2655 perillic acid 100 µM -0.633396125614053 0.248874743151694 no 2555 0.263237497226963 3528 5702197 An apoptosis inducer.
SGTC_3340 9146634 11.102 µM -0.633866351040334 0.248719685876337 no 2556 0.263084023499115 3569 4907387
SGTC_1768 st044301 37.178 µM -0.634102319078831 0.248641894584221 no 2557 0.263007024704867 3540 3931349
SGTC_479 n-linoleoylglycine 10 µM -0.634654928676972 0.248459767183663 no 2558 0.262826747603107 3534 6433346 An anti-infammatory.
SGTC_1310 1188-0297 994 nM -0.636846866984119 0.247738055599748 no 2559 0.26211229743687 3548 1588352
SGTC_2339 9000433 200 µM -0.637039861425076 0.247674564443452 no 2560 0.262049439674957 3506 2988954
SGTC_1569 carminic acid 40.6 µM -0.637741563619221 0.247443792275641 no 2561 0.261820962324302 3590 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2379 9035213 200 µM -0.637765183461625 0.247436026304293 no 2562 0.26181327337669 3599 646551
SGTC_473 2-arachidonoylglycerol 10 µM -0.638100371835156 0.247325833712428 no 2563 0.261704172270452 3495 5282280 An endocannabinoid.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.63837903394216 0.247234244006038 no 2564 0.26161348776881 3610 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.638433621437751 0.247216304499614 no 2565 0.261595725348889 3548 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_932 2857-0803 154 µM -0.641383140266745 0.246248017312116 no 2566 0.260636892068887 3649 674898
SGTC_2142 5622915 118.518 µM -0.641465119248865 0.246221133794178 no 2567 0.260610268099673 3554 5322196
SGTC_2303 7774051 200 µM -0.64278294363075 0.245789193291862 no 2568 0.260182476034427 3584 2953184
SGTC_3045 9092950 49.47 µM -0.643170633393378 0.245662198523272 no 2569 0.260056693144264 3615 44120432
SGTC_1120 ficusin 1.78878 µM -0.643538852042228 0.24554161450352 no 2570 0.259937256540615 3602 6199 A DNA cross-linker.
SGTC_3316 9136639 10.545 µM -0.645173543212292 0.245006670958368 no 2571 0.259407364586475 3578 4903665
SGTC_2939 9044578 71.43 µM -0.646603402031193 0.244539272209186 no 2572 0.258944327825656 3568 2653634
SGTC_3189 9110682 49.47 µM -0.647745541742966 0.244166269724371 no 2573 0.258574771650522 3614 17122418
SGTC_2806 7952793 58.44 µM -0.648070890121847 0.244060072909024 no 2574 0.258469550379137 3602 2972490
SGTC_1906 st060206 94.7 µM -0.648878644782063 0.243796521822298 no 2575 0.258208409490968 3586 5133468
SGTC_2111 5486399 200 µM -0.650528509096886 0.243258688085557 no 2576 0.257675446299628 3609 689674
SGTC_2406 ethylparaben 405.7 µM -0.651850320722097 0.242828258318319 no 2577 0.257248867923534 3419 8434 A possible steroid mimic.
SGTC_666 0272-0154 136 µM -0.651867914522914 0.242822531920027 no 2578 0.257243192484485 3599 6870312
SGTC_257 daunorubicin 18.5 µM -0.652535058878657 0.24260544492371 no 2579 0.257028031930015 3634 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_704 1310-0270 142 µM -0.653401638966372 0.24232361905574 no 2580 0.256748691239994 3585 5718033
SGTC_2849 9019321 12.99 µM -0.653547107672193 0.242276327674855 no 2581 0.256701815134344 3567 16489627
SGTC_550 4123-0385 25.7 µM -0.653814078031765 0.242189549535259 no 2582 0.256615797704721 3596 5731123
SGTC_1983 st071813 46.9 µM -0.657206164179266 0.241088427770626 no 2583 0.255524181288076 3586 11838595
SGTC_971 1315-0384 26.7 µM -0.657343913776664 0.241043769780744 no 2584 0.255479903030664 3602 6769120
SGTC_236 1509-0011 5.31 µM -0.657704462695252 0.240926902243637 no 2585 0.255364027097311 3688 3107280
SGTC_1506 4226-2149 212 µM -0.658087595060722 0.240802748341688 no 2586 0.255240923235732 3625 991114
SGTC_2068 5226020 147 µM -0.661354109598753 0.239745650472839 no 2587 0.254192624141815 3634 1810509
SGTC_2553 4-methylesculetin 85.09 µM -0.661970854112488 0.239546346354005 no 2588 0.253994950440554 3614 5319502
SGTC_1259 0671-0132 43 µM -0.662835905536782 0.239266953074084 no 2589 0.253717827486346 3558 X1259
SGTC_2128 5255449 168.493 µM -0.665954059769702 0.238261334405042 no 2590 0.252720232460984 3630 736008
SGTC_1523 st012844 44.7 µM -0.666498175950086 0.238086092068798 no 2591 0.252546364593092 3631 4274103
SGTC_2891 9063876 19.48 µM -0.667204589158548 0.237858684500648 no 2592 0.252320730096258 3586 6472478
SGTC_258 haloperidol 50.781 µM -0.667665430441735 0.237710395331293 no 2593 0.252173590699994 3597 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2073 5212005 126 µM -0.668566944256562 0.237420453584413 no 2594 0.251885882378328 3510 691789
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.66894458604777 0.237299055466608 no 2595 0.251765413622592 3660 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3102 9121669 49.47 µM -0.669086928462325 0.237253306398805 no 2596 0.251720013902047 3632 41905072
SGTC_1418 3966-3099 2.4 µM -0.669858833848115 0.237005299224021 no 2597 0.251473892118368 3628 740335
SGTC_903 1134-0042 114 µM -0.67057119650991 0.236776549142349 no 2598 0.251246868397315 3624 701009
SGTC_97 0535-0701 19.132 µM -0.67304934278507 0.235981726764945 no 2599 0.250457949994377 3593 2832013 YGL099W LSG1
SGTC_3346 9158254 43.5805 µM -0.673811945257449 0.235737431450298 no 2600 0.250215439756665 3604 17639500
SGTC_1526 st051518 75 µM -0.675594153360168 0.235167055512544 no 2601 0.249649177300633 3605 673993
SGTC_1222 0366-0074 1.18 µM -0.67625295208648 0.234956407379997 no 2602 0.24944002907851 3663 286520
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.677022354074551 0.234710526358909 no 2603 0.249195885675263 3711 6710655
SGTC_807 1315-0151 48 µM -0.677916718725807 0.234424889392758 no 2604 0.248912249443885 3669 4011080
SGTC_3148 9097893 49.47 µM -0.678929842943303 0.234101556169643 no 2605 0.248591157828098 3582 17174100
SGTC_662 k832-1615 104 µM -0.678945059871528 0.234096701650955 no 2606 0.248586336777154 3634 5878478
SGTC_2847 9005661 71.43 µM -0.679015225016793 0.234074318221813 no 2607 0.248564107590683 3553 2991449
SGTC_592 k241-0073 46.5 µM -0.679461976952749 0.23393182739639 no 2608 0.248422595888977 3655 4230158
SGTC_1325 1431-0015 227 µM -0.679691311838558 0.233858700066831 no 2609 0.248349969192335 3592 1103340
SGTC_2699 st077704 54.6 µM -0.680029188924481 0.233750985293194 no 2610 0.248242989538807 3651 645852
SGTC_1077 5-fluorocytosine 377 nM -0.680121332120581 0.233721614935755 no 2611 0.248213819149412 3632 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2587 piperic acid 92.2 µM -0.680344204990498 0.233650583359702 no 2612 0.248143270348997 3611 5370536
SGTC_3122 9126309 49.47 µM -0.681326556370803 0.233337641876815 no 2613 0.247832441603525 3684 17591206
SGTC_304 1310-0298 97 µM -0.682073399433865 0.233099880498454 no 2614 0.247596269899981 3590 1550234
SGTC_1232 0279-0259 161 µM -0.682089685203089 0.233094697338029 no 2615 0.247591121244936 3667 1560000
SGTC_1147 3809-1045 12.3 µM -0.683865817969072 0.232529803909133 no 2616 0.247029950190754 3608 325925
SGTC_2879 9041815 71.43 µM -0.684604153233677 0.23229520288143 no 2617 0.246796872762962 3603 4942971
SGTC_2482 5981709 142.65 µM -0.68580665652712 0.231913397655406 no 2618 0.246417519086885 3642 877755
SGTC_1985 st071382 65.5 µM -0.686586554983176 0.231665960085722 no 2619 0.246171651705827 3684 6123237
SGTC_2240 6690706 185.951 µM -0.686939883720039 0.231553908288271 no 2620 0.246060306148593 3591 805876
SGTC_2242 6630449 61.2675 µM -0.687727392086824 0.231304273039979 no 2621 0.245812233489517 3661 691249 YDR170C SEC7
SGTC_2456 5770359 74.46 µM -0.688674542948862 0.231004231063989 no 2622 0.245514049846933 3665 3118787
SGTC_942 3253-1115 227 µM -0.690034029190666 0.230573947925635 no 2623 0.245086393945119 3695 46497897
SGTC_769 0302-0231 76 µM -0.690375894305052 0.230465816690337 no 2624 0.244978915934257 3663 571869 YER009W NTF2
SGTC_1255 0566-0045 221 µM -0.69085224853857 0.230315194099355 no 2625 0.244829198562342 3688 2788469
SGTC_3042 9091578 49.47 µM -0.691915354198342 0.229979240064662 no 2626 0.244495243836327 3626 25236497
SGTC_1329 1447-1697 50.6 µM -0.691962573185779 0.229964324667091 no 2627 0.244480416570227 3647 2840515
SGTC_2970 9090938 41.86 µM -0.69209838636668 0.229921427409469 no 2628 0.244437772482321 3664 17217104
SGTC_1003 4049-0218 100 µM -0.694084387641282 0.229294651080649 no 2629 0.243814644434166 3686 295161
SGTC_1927 st060202 13.8 µM -0.694299623339772 0.229226780890933 no 2630 0.243747163581376 3635 688887
SGTC_3209 9113616 49.47 µM -0.695251252546226 0.228926839066658 no 2631 0.243448928970197 3691 16649353
SGTC_1887 st057648 70.8 µM -0.698542014695496 0.227891330742801 no 2632 0.242419146104509 3656 688672
SGTC_3120 9124077 49.47 µM -0.69923745277149 0.227672834158539 no 2633 0.242201824131884 3722 18774327 YGL155W CDC43
SGTC_225 nsc-122657 1.016 µM -0.700127742549034 0.227393290191849 no 2634 0.241923765893128 3630 275685
SGTC_1442 4112-3290 3 µM -0.701575899792953 0.226938993570778 no 2635 0.241471842832437 3669 704353
SGTC_1152 3909-8331 15.9 µM -0.701802151652567 0.226868063110942 no 2636 0.241401278379153 3663 16001939
SGTC_64 000l-0018 272.079 µM -0.701838896336587 0.226856544751525 no 2637 0.241389819338381 3630 6811119
SGTC_758 0868-0029 16 µM -0.702607850049441 0.226615576461591 no 2638 0.241150084517921 3695 762687
SGTC_1773 st048542 73.5835 µM -0.702864222387543 0.226535268765691 no 2639 0.241070184719441 3630 3237138
SGTC_261 5-fluorouridine 15.376 µM -0.704394595745261 0.226056219265635 no 2640 0.240593535298474 3715 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3106 9121286 49.47 µM -0.704597563088604 0.22599272786732 no 2641 0.240530357736956 3699 15943471
SGTC_1989 st071868 50.2 µM -0.704762183492532 0.225941239403731 no 2642 0.240479123046757 3666 16414057
SGTC_1827 berberine 7.24 µM -0.706689042876851 0.225339067337595 no 2643 0.239879870116576 3634 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1776 st049249 45.9 µM -0.706846503350939 0.225289898808153 no 2644 0.239830935962878 3710 1822314
SGTC_825 1988-2224 89.6 µM -0.708644525722064 0.224728880214259 no 2645 0.239272549002133 3704 1180859
SGTC_1071 trifluoperazine 6.31 µM -0.709961447966984 0.224318477538558 no 2646 0.238864021707918 3758 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1265 0819-1001 68.8 µM -0.71049034688435 0.22415377250199 no 2647 0.238700057463953 3690 3106768
SGTC_2175 5807670 165.306 µM -0.710815902295619 0.22405242506497 no 2648 0.238599162479872 3642 241186
SGTC_2517 totarol 10 µM -0.710816762271886 0.224052157383451 no 2649 0.238598895989976 3663 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_824 1304-0008 100 µM -0.712559367102427 0.223510116736009 no 2650 0.238059231433154 3709 768245
SGTC_1851 st056236 18.9 µM -0.713641525273516 0.223173885098444 no 2651 0.237724436584432 3698 5393171
SGTC_68 0986-0284 82.829 µM -0.714322807697501 0.222962355232087 no 2652 0.237513796033654 3711 423278 YIL048W NEO1
SGTC_781 4335-2806 94.4 µM -0.715173847537676 0.222698278261878 no 2653 0.237250813449691 3808 845254
SGTC_756 0508-1999 28.3 µM -0.715839797209754 0.222491759008267 no 2654 0.237045137771266 3683 6753853
SGTC_2041 5107442 45.335 µM -0.716973361339508 0.222140478000288 no 2655 0.236695266849179 3699 793005
SGTC_40 0327-0103 19.753 µM -0.719197566662624 0.221452138123176 no 2656 0.2360095992419 3637 409036
SGTC_3304 9125678 46.087 µM -0.71944424602055 0.221375871785878 no 2657 0.235933621568226 3702 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3046 9092212 49.47 µM -0.719811698369812 0.221262293681666 no 2658 0.235820470602917 3718 25236637
SGTC_3063 1327-0034 4 µM -0.722887969994169 0.220312738482987 no 2659 0.234874357503647 3624 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_409 arachidonic acid 100 µM -0.723417873976802 0.22014940880167 no 2660 0.234711596610242 3724 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3091 9116372 49.47 µM -0.72513458583296 0.219620752387575 no 2661 0.234184734213112 3727 17169793
SGTC_3138 9097216 49.47 µM -0.725830354549145 0.219406700225768 no 2662 0.233971387980604 3720 25237486
SGTC_736 0958-0254 92.6 µM -0.725932289073008 0.219375350298732 no 2663 0.233940140451506 3770 6812352
SGTC_1828 st055811 49 µM -0.727180402152866 0.218991702319829 no 2664 0.233557725022508 3682 5877589
SGTC_611 3453-1652 23.7 µM -0.727248154127299 0.218970887604281 no 2665 0.233536976090709 3701 1560575
SGTC_1087 pterostilbene 9.05 µM -0.728863501721572 0.218474958713636 no 2666 0.233042581377586 3739 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1881 5652484 16 µM -0.730493200473872 0.217975279957725 no 2667 0.23254438385544 3684 2255129
SGTC_1629 st005085 44.9 µM -0.730569374284154 0.217951940584656 no 2668 0.23252111208185 3730 24207091
SGTC_882 0843-0131 351 µM -0.736471857733736 0.216147827898652 no 2669 0.230721794026162 3735 5425421
SGTC_1084 voriconazole 435 nM -0.736749164911228 0.216063281324836 no 2670 0.230637451198187 3735 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.73684787423498 0.21603319103617 no 2671 0.230607432968752 3689 279621
SGTC_2620 irigenin 100 µM -0.73727874784682 0.215901873093857 no 2672 0.230476426709301 3755 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.737743246672816 0.215760358971378 no 2673 0.230335243379393 3737 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3331 9141060 1.957 µM -0.738449372201009 0.215545333930513 no 2674 0.230120710845507 3728 4906567 YPR165W RHO1
SGTC_510 ag-490 170 µM -0.740402261118225 0.214951299652377 no 2675 0.229527973618013 3858 5328779
SGTC_2308 7584454 197.62 µM -0.740420479978978 0.2149457622773 no 2676 0.229522447893731 3766 893577
SGTC_3135 9127742 49.47 µM -0.742737446581821 0.214242227260732 no 2677 0.228820326863361 3806 3643468
SGTC_460 trequinsin 123 µM -0.743136723989336 0.214121124186572 no 2678 0.228699453895744 3788 5537 A vasodilator.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.745002274991765 0.213555820245772 no 2679 0.228135172292097 3721 7104
SGTC_173 1273-0061 2.693 µM -0.746942787447582 0.212968725111334 no 2680 0.227549048358382 3731 2847414 YPL266W DIM1
SGTC_780 0109-0199 192 µM -0.747999955167804 0.212649279479836 no 2681 0.227230092292187 3769 610414
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.751269348316591 0.211663135496692 no 2682 0.226245286081484 3822 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_278 4092-0821 23.9 µM -0.751338428136675 0.211642327933071 no 2683 0.226224503912695 3759 877900
SGTC_3069 9117009 49.47 µM -0.753002488532844 0.211141457467193 no 2684 0.225724209308151 3683 41904981
SGTC_1560 lithocholic acid 53.1 µM -0.753816379670436 0.210896735145044 no 2685 0.225479743565652 3678 9903 A bile acid which acts as a detergent.
SGTC_2461 5755302 26.15 µM -0.753953083545539 0.210855647086196 no 2686 0.225438696987966 3740 2788904
SGTC_2277 7947813 106.88 µM -0.754000752067075 0.210841320819986 no 2687 0.225424385077009 3834 1246798
SGTC_430 0958-0115 16.4 µM -0.754609014883265 0.210658564032542 no 2688 0.225241806510177 3749 6833180
SGTC_1225 1216-0074 20.6 µM -0.75474589361257 0.210617450681972 no 2689 0.225200731998194 3766 4241466
SGTC_1007 4101-0031 70 µM -0.755026545619554 0.210533167835933 no 2690 0.225116527330487 3705 1146276
SGTC_2675 theaflavin digallate 100 µM -0.755577800029156 0.210367677782985 no 2691 0.224951185141139 3735 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1080 nisoldipine 24.4 µM -0.757485480076197 0.209795569963431 no 2692 0.224379530812317 3755 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3109 9122853 49.47 µM -0.757928524722747 0.209662833133764 no 2693 0.224246886386254 3827 1234709
SGTC_3190 9110366 49.47 µM -0.760018376413123 0.20903737674144 no 2694 0.223621800273152 3701 17123768
SGTC_235 0330-0087 5 mM -0.760832074256537 0.208794148599327 no 2695 0.223378687045836 3813 46494818 YHR062C RPP1
SGTC_519 k048-0011 62.8 µM -0.762791788695542 0.208209041504853 no 2696 0.222793789476119 3849 6836379
SGTC_427 1354-0053 47.3 µM -0.763279714437931 0.208063513293983 no 2697 0.222648298667938 3886 6813657
SGTC_2281 7943571 200 µM -0.76334479115906 0.208044108119557 no 2698 0.22262889803739 3877 1244024
SGTC_2323 6148992 148.28 µM -0.76403931096595 0.207837076374159 no 2699 0.222421908268701 3769 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_700 3453-2283 142 µM -0.764432222702984 0.207720005900097 no 2700 0.222304856265318 3824 565664
SGTC_1655 st012546 55.1 µM -0.765063143421506 0.207532100702307 no 2701 0.222116972751959 3727 720985 YLR208W SEC13
SGTC_673 1082-0474 110 µM -0.766217314372688 0.207188617569813 no 2702 0.221773503862668 3791 3098046
SGTC_665 3914-0008 307 µM -0.767458353048237 0.206819657875116 no 2703 0.221404522823519 3753 1069549
SGTC_601 0986-0029 62.9 µM -0.769710371008836 0.206151129064819 no 2704 0.220735858360571 3764 24747981
SGTC_1116 jasmonic acid 1.58368 µM -0.770080503331774 0.206041375164409 no 2705 0.220626070216731 3809 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1122 capsaicin 818.572 nM -0.770141833438534 0.206023192533181 no 2706 0.220607881585863 3877 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.770631271278193 0.205878122245097 no 2707 0.220462760102318 3718 107982 A Capsaicinoid.
SGTC_954 1189-0853 2.85 µM -0.770678282600147 0.205864191192312 no 2708 0.220448823821932 3761 2828194
SGTC_2617 dihydrotanshinone i 20.83 µM -0.771759097069567 0.205544063380077 no 2709 0.220128560836565 3804 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1347 1493-0251 600 nM -0.7718964799068 0.205503392965163 no 2710 0.220087871182512 3822 3986378
SGTC_1941 st076221 61.8 µM -0.773300960065136 0.205087888934146 no 2711 0.219672143863648 3756 2828568
SGTC_2856 9022925 19.48 µM -0.773852926104738 0.204924731038765 no 2712 0.219508884954521 3812 4944862
SGTC_3054 9094397 49.47 µM -0.77398371358003 0.204886082347373 no 2713 0.219470211232053 3807 2598354
SGTC_2374 9071832 200 µM -0.774390308588578 0.204765958121466 no 2714 0.21935000650775 3728 17381698
SGTC_1209 2323-2347 50.3 µM -0.775105434677058 0.2045547832832 no 2715 0.219138680246594 3748 5412760
SGTC_1550 gossypolone 36.6 µM -0.775700077736219 0.204379285486267 no 2716 0.218963046986997 3802 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1752 st044819 83.042 µM -0.777172879412712 0.203945001671415 no 2717 0.218528390342466 3801 441209 YML126C ERG13
SGTC_444 curcumin 90.4 µM -0.777533534234547 0.203838739555689 no 2718 0.218422028829708 3756 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2865 9030313 51.95 µM -0.777560241591038 0.20383087190315 no 2719 0.218414153689909 3746 42562754
SGTC_2058 5236698 133 µM -0.777706166981997 0.203787887308001 no 2720 0.218371127876969 3800 766665
SGTC_2669 eugenol 100 µM -0.777797783058902 0.203760903127992 no 2721 0.218344117552851 3754 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_618 k072-0232 33.2 µM -0.778056771247108 0.203684633454691 no 2722 0.218267772861661 3828 5872756 YGL099W LSG1
SGTC_1645 Cervolide 78 µM -0.778253062302408 0.203626838859681 no 2723 0.218209920315682 3777 23173 A fragrance.
SGTC_2600 tangeritin 87.95 µM -0.778863768991673 0.203447089113604 no 2724 0.218029984240309 3753 68077 A bioactive flavone.
SGTC_2838 9002687 71.43 µM -0.780851408403159 0.202862721491026 no 2725 0.217444947024964 3797 6457060
SGTC_2896 9052656 71.43 µM -0.781778330918274 0.202590548679885 no 2726 0.217172428943627 3745 6469436
SGTC_1643 st009866 20.2 µM -0.782359652147016 0.202419966404202 no 2727 0.21700161942644 3775 3156273 YOR207C RET1
SGTC_2015 5119600 184 µM -0.784740192795086 0.201722319607229 no 2728 0.216302956055875 3826 2828786
SGTC_32 0928-0142 34.1 µM -0.784900164437009 0.201675489638577 no 2729 0.216256052819846 3763 2244242
SGTC_1 0258-0098 57.368 µM -0.785014775373066 0.201641942530392 no 2730 0.216222452836221 3742 6790032 YDR047W HEM12
SGTC_34 0469-0683 81.75 µM -0.785239009566066 0.20157631789722 no 2731 0.216156723827735 3794 3690923
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.785852170674486 0.201396934815845 no 2732 0.215977049082626 3876 688801
SGTC_715 0868-0130 184 µM -0.786107786357995 0.201322181546094 no 2733 0.215902171519895 3830 2876258
SGTC_1433 4060-0023 7.6 µM -0.786846152031185 0.201106344376299 no 2734 0.215685966388241 3813 3840627
SGTC_2413 inermin 26.06 µM -0.788277869439233 0.2006882240446 no 2735 0.215267094774737 3900 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3055 9094636 49.47 µM -0.788656703265956 0.200577676367613 no 2736 0.215156339970099 3797 25236176
SGTC_2488 5268135 45.7 µM -0.790781590055386 0.199958290173961 no 2737 0.214535727382307 3880 1270356 YLR208W SEC13
SGTC_2165 5727197 32.143 µM -0.790929574576252 0.199915196840574 no 2738 0.214492544556305 3913 1361712
SGTC_1642 st009582 77.7 µM -0.791194585000819 0.199838039330768 no 2739 0.214415225455723 3783 6739311
SGTC_691 1548-0686 185 µM -0.793412302394005 0.199193055582251 no 2740 0.213768822705613 3838 46495133
SGTC_1756 st041558 35.5 µM -0.793432715129178 0.19918712473014 no 2741 0.213762878238991 3874 3955792
SGTC_1611 st001856 99.4 µM -0.794113170804787 0.198989481479166 no 2742 0.213564775376743 3812 647478
SGTC_1610 st001799 48.1 µM -0.794777185111252 0.198796727716169 no 2743 0.213371562303814 3746 621897
SGTC_749 1000-0129 128 µM -0.794788983373688 0.198793303869082 no 2744 0.213368130199208 3860 708470
SGTC_862 0452-0056 10.2 µM -0.795012614411875 0.198728413029498 no 2745 0.213303082205066 3772 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1278 0874-0585 172 µM -0.795341895701703 0.198632888991941 no 2746 0.213207324566463 3882 766306
SGTC_2981 9013952 38.96 µM -0.795876536694747 0.19847784938878 no 2747 0.213051900090178 3768 2996344
SGTC_3150 9097574 49.47 µM -0.796006376087922 0.19844020851186 no 2748 0.213014164702662 3807 17217476
SGTC_2768 sulfasalazine 50.2 µM -0.796144724607508 0.198400105550571 no 2749 0.21297396058856 3814 5384001 An antioxidant and salicylic acid derivative.
SGTC_3060 1327-0027 12.5 µM -0.796256862172483 0.198367603923736 no 2750 0.212941376633497 3761 16000455 YPR107C YTH1
SGTC_2859 9028643 45.46 µM -0.796340457647689 0.198343376943969 no 2751 0.212917088082593 3747 17151580
SGTC_965 1291-5240 308 µM -0.797094623346631 0.198124891333198 no 2752 0.212698039368863 3800 2834598
SGTC_2295 7971645 200 µM -0.79767132960832 0.197957914704062 no 2753 0.212530622869698 3874 2978226 YKL099C UTP11
SGTC_3257 9139206 32.98 µM -0.798091388755018 0.197836346411561 no 2754 0.212408729132417 3854 4910041
SGTC_1262 0737-0114 49.6 µM -0.798747143297567 0.197646656281371 no 2755 0.212218522438403 3862 765919
SGTC_2874 9043904 71.43 µM -0.799594718834 0.197401641023599 no 2756 0.211972824145585 3816 4463428
SGTC_887 0885-0007 9.62 µM -0.809068095054249 0.19467561644617 no 2757 0.209237989428284 3936 5719458
SGTC_3267 9137951 49.47 µM -0.809341161736005 0.194597380896907 no 2758 0.209159468010837 3848 16643986
SGTC_1298 1079-1278 263 µM -0.809774939108006 0.19447313993347 no 2759 0.209034769266853 3874 2840950
SGTC_3223 9129970 49.47 µM -0.811406787177462 0.194006184475642 no 2760 0.208566051368449 3874 17248386
SGTC_880 0833-0487 87.2 µM -0.813020705019659 0.193545032362055 no 2761 0.208103093622026 3847 76075
SGTC_2915 7971052 15.16 µM -0.813583669006787 0.193384331502137 no 2762 0.207941748304304 3693 5741558
SGTC_291 SEC14.278 35.5 µM -0.814397499726184 0.193152163453795 no 2763 0.207708635259973 3841 1068044
SGTC_967 1306-0166 352 µM -0.815956580704847 0.192707867331738 no 2764 0.207262484715032 3803 4437607
SGTC_996 3970-0799 1.8 µM -0.816111058559489 0.192663879329492 no 2765 0.207218309820995 3894 6615648 YGL040C HEM2
SGTC_2902 5787006 60.46 µM -0.817183622289419 0.19235863303392 no 2766 0.206911750253975 3816 591003
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.818658867636913 0.191939269004563 no 2767 0.206490535230655 3881 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2093 5331342 194.4 µM -0.819212320319407 0.191782084958391 no 2768 0.206332643433589 3913 33839
SGTC_2690 usnic acid 100 µM -0.81938255525226 0.191733753019836 no 2769 0.206284092337956 3854 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2211 7117706 200 µM -0.819867619056285 0.191596077930186 no 2770 0.206145789015931 3768 822771
SGTC_99 0109-0120 622.8 µM -0.820135503572517 0.19152007054497 no 2771 0.206069432286761 3863 759414
SGTC_1853 st056710 91.2 µM -0.820837986359834 0.191320841515733 no 2772 0.205869279079497 3958 269167
SGTC_474 dl-dihydrosphingosine 5 µM -0.823337136430449 0.19061309546365 no 2773 0.205158150409116 3859 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2492 derrusnin 100 µM -0.823777027106859 0.190488687300738 no 2774 0.205033131554348 3776 1715307 Part of coumarin class of compounds.
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.833228221694465 0.187827793267489 no 2775 0.202358014480655 3877 2724 A muscle relaxant with antifungal properties.
SGTC_1971 st069429 63.5 µM -0.834335009635073 0.187517696102139 no 2776 0.202046114390691 3891 1246522 YGL099W LSG1
SGTC_1386 3228-0095 33.8 µM -0.83580134131166 0.187107350402578 no 2777 0.20163333589722 3898 870181
SGTC_1824 st053723 68.6 µM -0.835825287488507 0.187100653795351 no 2778 0.201626599143271 3909 675225
SGTC_2671 danthron 100 µM -0.838055441547423 0.186477635663821 no 2779 0.200999783313773 3873 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1830 st055982 50.3 µM -0.839303829815756 0.186129446238461 no 2780 0.200649417323415 3790 455313 An antimicrobial agent.
SGTC_2952 9073731 13.78 µM -0.840585179637418 0.185772482833371 no 2781 0.200290182093452 3947 16457353
SGTC_2112 5488546 200 µM -0.842283819170035 0.185299924344716 no 2782 0.199814552989074 3858 600757
SGTC_560 2332-1943 155 µM -0.84484785973855 0.184588027932248 no 2783 0.199097894540475 3873 21177716
SGTC_15 0266-0086 27.098 µM -0.845553528759279 0.184392400380339 no 2784 0.198900929614433 3971 1712902 YIL048W NEO1
SGTC_846 0335-0850 148 µM -0.846100069172156 0.184240975576976 no 2785 0.198748461082046 3895 6819598
SGTC_157 1348-1695 65.819 µM -0.848603390618223 0.183548393316235 no 2786 0.198051009828692 3866 5380510
SGTC_1939 st074455 53.6 µM -0.850422800381378 0.183046045308954 no 2787 0.197545032127155 3881 1644229
SGTC_1774 st048371 48.465 µM -0.853717222420327 0.182138624388943 no 2788 0.196630844605069 3874 4242727
SGTC_2360 9040895 200 µM -0.85584042413967 0.181555299049895 no 2789 0.196043025961391 3950 4914414
SGTC_653 0203-0016 55.2 µM -0.856112705922881 0.181480577428416 no 2790 0.195967720623263 3951 295302
SGTC_2341 7987486 176.74 µM -0.856341457301053 0.181417816631246 no 2791 0.195904468114725 3950 1258686
SGTC_2916 7875993 68.79 µM -0.857474431066042 0.18110717148076 no 2792 0.195591369893986 3821 1299250
SGTC_3096 9117468 49.47 µM -0.857603849335097 0.181071708066659 no 2793 0.195555624395919 3846 41316311
SGTC_3024 9090631 49.47 µM -0.859616481097144 0.180520763315435 no 2794 0.195000243490999 3866 25236383
SGTC_2480 5767542 37.17 µM -0.860014949798636 0.180411809943305 no 2795 0.194890400841001 3891 2867358
SGTC_1891 st059073 26.2 µM -0.860617473294146 0.180247140204305 no 2796 0.194724379534549 3993 688754
SGTC_1628 st004252 77.7 µM -0.860936753446555 0.180159919151159 no 2797 0.194636438917157 3949 692968
SGTC_55 0767-0285 6.563 µM -0.861948662597172 0.179883660568699 no 2798 0.194357884409228 3844 3116166
SGTC_324 1315-0088 19.6 µM -0.862074245974225 0.179849393958716 no 2799 0.194323331232564 3893 6787421
SGTC_469 w7 172 µM -0.86233868980923 0.179777251369735 no 2800 0.194250584037162 3956 45115570 A P450 inhibitor.
SGTC_2927 9011802 47.9 µM -0.863949416826213 0.17933822365117 no 2801 0.19380783923786 3943 43912568
SGTC_414 piperonyl butoxide 100 µM -0.86567761601016 0.178867927511849 no 2802 0.193333489241796 3910 5794 A potent inhibitor of cytochrome P450.
SGTC_514 4466-0038 2.65 nM -0.866396746968865 0.178672458783875 no 2803 0.193136313633813 3809 5722064
SGTC_2645 abamectin 100 µM -0.866848063281829 0.178549854124154 no 2804 0.193012631761766 3868 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2629 bisabolol 100 µM -0.86748301224854 0.178377453526659 no 2805 0.192838707825462 3962 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2372 9071633 200 µM -0.869441157578538 0.177846440957345 no 2806 0.192302939802131 3982 21321366
SGTC_2373 9071805 200 µM -0.869692641054135 0.177778315641542 no 2807 0.192234197452384 3882 10149009
SGTC_1494 4358-1428 177 µM -0.870106461038088 0.177666250208663 no 2808 0.192121113565116 3935 1564571
SGTC_2327 6189656 200 µM -0.87229585283716 0.177074089141831 no 2809 0.191523499746151 4015 5349088
SGTC_3244 9134489 49.47 µM -0.876911719870333 0.175829734535406 no 2810 0.190267294974248 3958 16584271
SGTC_3202 9113761 49.47 µM -0.87768840089384 0.175620901011885 no 2811 0.19005642040336 3976 4798415
SGTC_999 SEC7.066 22.7 µM -0.879763893510488 0.175063615368737 no 2812 0.189493614161944 3930 740511 YDR170C SEC7
SGTC_3194 9111903 49.47 µM -0.879889131367292 0.175030023974364 no 2813 0.189459686559846 3965 17087251
SGTC_1859 st055998 20 µM -0.880142283888279 0.17496213569863 no 2814 0.189391117610406 3887 676301
SGTC_1886 st057356 49.9 µM -0.881931947418503 0.174482675735497 no 2815 0.188906804729227 3909 24207747
SGTC_1101 ebselen 5.29 µM -0.88309113048452 0.174172570449235 no 2816 0.188593517971879 4015 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_989 1501-0895 10.3 µM -0.883703813335701 0.174008806786822 no 2817 0.188428060640178 3892 2830112
SGTC_539 4859-0462 2.54 µM -0.8837223793818 0.174003845807244 no 2818 0.188423048206896 3998 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1337 1486-1011 40.3 µM -0.884419440279648 0.17381765124671 no 2819 0.188234916261496 3931 X1337
SGTC_791 1348-1292 225 µM -0.885846509964329 0.173436856737254 no 2820 0.187850121653629 3923 5437054
SGTC_1778 st046819 58.9 µM -0.887396179024473 0.173023950098722 no 2821 0.18743281997146 4009 671715
SGTC_563 tetrahydrosecaminediol 614 µM -0.887666128031946 0.172952086751896 no 2822 0.187360185561796 4017 334274 A psychoactive constituent of the cannabis plant.
SGTC_2659 sanguinarine 24.21 µM -0.888049435137912 0.172850078930882 no 2823 0.187257080111225 3889 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_830 4076-0286 57.8 µM -0.888779307320348 0.172655947321091 no 2824 0.187060849443996 4023 6866659
SGTC_1739 st037196 92.5 µM -0.891316307348722 0.171982237189873 no 2825 0.186379751287099 4022 612214
SGTC_866 0495-0101 262 µM -0.892776282040798 0.171595297142686 no 2826 0.185988495108735 3907 635694
SGTC_2692 st077426 47.7 µM -0.893325958852153 0.171449759429726 no 2827 0.185841320190085 3976 25238571
SGTC_569 4130-2812 160 µM -0.894071839523019 0.171252399093135 no 2828 0.185641727601927 3777 743552
SGTC_2250 alverine citrate 130 µM -0.894089940173955 0.171247611459333 no 2829 0.185636885644583 3860 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_565 1418-0001 44.5 µM -0.89416143412482 0.171228702099961 no 2830 0.185617761647516 4036 2862145
SGTC_1276 0871-0068 94.2 µM -0.895018283206223 0.171002178884546 no 2831 0.185388657256622 3970 3414906
SGTC_2551 apiole 73.87 µM -0.898128397838313 0.170181576667353 no 2832 0.184558550451023 3793 10659 A possible DNA adduct former.
SGTC_1236 0330-0013 258 µM -0.89860821921931 0.170055201071546 no 2833 0.184430689600438 3984 4617066
SGTC_1738 st035555 74 µM -0.898665448877621 0.170040131911355 no 2834 0.184415442952784 4037 5331140
SGTC_588 3970-1144 52.9 µM -0.900529397762827 0.169549802846763 no 2835 0.183919293970102 3874 1888707
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.901805207859328 0.169214712639875 no 2836 0.183580176412159 3996 2374 Ca(2+)-ATPase inhibitor.
SGTC_956 1185-0240 191 µM -0.903883820448767 0.168669678534892 no 2837 0.183028504641543 3975 1416193
SGTC_1883 5-benzylidenerhodanine 20 µM -0.905834686931042 0.168159168436218 no 2838 0.182511679186531 3973 1273210
SGTC_1464 k208-0027 110 µM -0.905931529999648 0.168133852103587 no 2839 0.182486047196484 3933 X1464
SGTC_3175 9106517 49.47 µM -0.906265823588382 0.16804648123796 no 2840 0.182397585143964 4009 41468073
SGTC_282 k297-0036 65.7 µM -0.907966360432512 0.167602481930622 no 2841 0.18194799745585 3986 5061378
SGTC_488 nitrendipine 139 µM -0.908726582713578 0.167404237377539 no 2842 0.181747234342602 4027 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2686 alizarin 95.37 µM -0.909321417040886 0.167249226753965 no 2843 0.181590244348209 3996 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_343 4130-2827 29.8 µM -0.909897636143085 0.167099155408171 no 2844 0.181438248273975 4017 1118244
SGTC_1796 st049173 110.4 µM -0.91688511900297 0.165286238516484 no 2845 0.179601421302721 3907 94134
SGTC_2704 st078022 71.1 µM -0.917597771060181 0.165102057404465 no 2846 0.179414742626069 4041 54697681
SGTC_995 3931-2021 34.6 µM -0.919388018519815 0.164639963865179 no 2847 0.178946327004581 4002 730143
SGTC_1217 1183-1422 255 µM -0.92475053717621 0.163260825817865 no 2848 0.177547842471374 4026 2849664
SGTC_2539 epi(13)torulosol 80 µM -0.925049339252414 0.163184201006158 no 2849 0.177470121671196 4047 6708597
SGTC_372 0155-0182 15.9 µM -0.925072435623176 0.163178279145468 no 2850 0.177464115015486 3918 771486
SGTC_2378 9074213 121.43 µM -0.925924732758548 0.16295984962431 no 2851 0.177242548494639 3966 657714
SGTC_990 3985-0011 41.3 µM -0.926419840022298 0.162833049228364 no 2852 0.177113918715785 3995 5399565 YGL099W LSG1
SGTC_2848 9016370 25.97 µM -0.927620125599126 0.162525914177416 no 2853 0.176802327157462 3976 7894410
SGTC_2333 9017922 200 µM -0.928460691628329 0.162311050529602 no 2854 0.17658432445226 4070 3163164
SGTC_1306 1185-0270 9.02 µM -0.934357163447824 0.160809008128876 no 2855 0.175059843252848 4045 1548076
SGTC_315 k915-0449 187 µM -0.935154345038739 0.160606636094549 no 2856 0.174854381520502 4029 20970215 YNL149C PGA2
SGTC_3116 9124943 49.47 µM -0.935248142842081 0.160582835583723 no 2857 0.174830216595043 3996 41905195 YPL160W CDC60
SGTC_2736 butenafine 14.65 µM -0.936305451761358 0.160314710490784 no 2858 0.174557971006652 3958 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1914 st062367 72.6 µM -0.937672473002301 0.159968478773226 no 2859 0.174206377156562 4007 978205
SGTC_2726 cimetidine 79.27 µM -0.938332832970062 0.159801401689271 no 2860 0.174036695840198 3999 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2139 5578692 56.4705 µM -0.939118501339919 0.159602769201494 no 2861 0.173834953103149 3973 650991 YMR113W FOL3
SGTC_2965 9082772 38.63 µM -0.940095832707866 0.159355906139582 no 2862 0.173584203107036 4035 16459634
SGTC_1725 st036284 20.55 µM -0.942163766736765 0.15883439354989 no 2863 0.17305440069441 4122 707914
SGTC_1219 1469-0211 33.1 µM -0.944693731868888 0.158197884482412 no 2864 0.172407629019023 4034 6822282
SGTC_2364 9055074 200 µM -0.94680572728302 0.157667815363127 no 2865 0.171868891408112 4061 6470630
SGTC_447 ml7 120 µM -0.946853439739241 0.157655853972366 no 2866 0.171856733123029 4044 4216 Selective myosin light chain kinase inhibitor.
SGTC_314 1671-0008 2.74 µM -0.949132218630822 0.157085264125521 no 2867 0.171276684897591 3918 3913060
SGTC_1703 st026983 48.3 µM -0.949420621735167 0.157013147008119 no 2868 0.171203363112088 4048 1104023
SGTC_1946 st076057 65.1 µM -0.950113826035957 0.15683989575258 no 2869 0.17102720933674 3964 953009
SGTC_1527 coumarin 137 µM -0.950685933957533 0.156697004673687 no 2870 0.170881915355433 4142 323 A hepatotoxic, DNA x-linker.
SGTC_1137 ixabepilone 100 µM -0.951453279246554 0.156505485209538 no 2871 0.170687162441421 3991 154225 A novel microtubule stabilizer.
SGTC_1449 4112-4002 201 µM -0.952896667602241 0.156145651937995 no 2872 0.170321214340711 4095 2059539
SGTC_937 3122-0005 46.7 µM -0.956339812287807 0.155289487061965 no 2873 0.169450291037879 4080 759535
SGTC_482 fipronil 114 µM -0.958849528690774 0.154667382378671 no 2874 0.168817276931148 4116 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_386 1509-0011 3.07 µM -0.962264619129295 0.153823503698713 no 2875 0.167958348383665 4053 3107280
SGTC_2703 st077852 53.4 µM -0.96289793991791 0.153667343919659 no 2876 0.167799371759343 4094 6281836
SGTC_623 k072-0108 16.9 µM -0.963794712705972 0.153446403599375 no 2877 0.167574429010532 4010 5382803
SGTC_2004 4023728 41.89 µM -0.96427537058319 0.153328069281911 no 2878 0.167453942785849 4040 360084 YDR527W RBA50
SGTC_3080 9117754 49.47 µM -0.96603306656892 0.152895852802467 no 2879 0.167013817574993 4070 9550191
SGTC_778 3456-2434 196 µM -0.967911240169427 0.152434904620483 no 2880 0.166544350119401 4030 5539063
SGTC_1321 1326-2144 215 µM -0.970113498597136 0.151895594255247 no 2881 0.165994960631718 4070 3513030
SGTC_3149 9097855 49.47 µM -0.974124034283495 0.150916715431331 no 2882 0.164997478654238 4060 25236625 YMR079W SEC14
SGTC_843 0310-0051 143 µM -0.979737866544426 0.149553576275064 no 2883 0.163607764662329 4090 2065037
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.980675659955323 0.149326666675487 no 2884 0.163376355248382 4139 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3125 9127534 49.47 µM -0.980805295910644 0.149295317899367 no 2885 0.163344383082672 3951 1639235
SGTC_1780 st038448 24.544 µM -0.98168953812139 0.149081606230592 no 2886 0.16312641051074 4124 728868 YDL195W SEC31
SGTC_163 TUB2.036 7.546 µM -0.983116211078554 0.14873722599786 no 2887 0.162775123294427 4054 15992207 YJR013W GPI14
SGTC_2344 7990960 76.95 µM -0.985174084774401 0.148241419477199 no 2888 0.16226928392489 4051 140813
SGTC_1282 0886-0010 32.4 µM -0.986011335843298 0.148040016160891 no 2889 0.1620637751036 4117 2836211 YNL267W PIK1
SGTC_3183 9108214 49.47 µM -0.986890953490587 0.147828618792661 no 2890 0.161848049799759 3998 4974831
SGTC_1093 fluphenazine 7.97 µM -0.989296490382177 0.147251531844245 no 2891 0.161259050345677 4073 6602611 An atypical antipsychotic.
SGTC_1431 4049-0260 9.09 µM -0.989703057277106 0.147154146051013 no 2892 0.161159640113869 4056 3854841
SGTC_1248 0469-0687 58.6 µM -0.990108548881723 0.147057060841469 no 2893 0.161060532636948 4075 4017482
SGTC_245 methotrexate 289.6 µM -0.990204842375389 0.147034011993121 no 2894 0.161037003086921 4054 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_624 k048-0052 28 µM -0.990918613855084 0.146863238902606 no 2895 0.160862661232479 4073 6835531
SGTC_1570 verbenone 133 µM -0.993831347042452 0.146167733841358 no 2896 0.160152491096466 4099 29025 A natural terpanoid with antifungal properties.
SGTC_760 0568-0725 82.9 µM -0.995727251405743 0.14571621861905 no 2897 0.159691342752585 4113 3916171
SGTC_1299 1079-1439 3.74 µM -0.99586012739964 0.145684609005906 no 2898 0.159659055411149 4048 323161
SGTC_3218 9131285 49.47 µM -0.996577502147032 0.145514033744672 no 2899 0.159484815374855 4048 17156417
SGTC_2279 7948423 32.93 µM -1.00166318418502 0.144308627226503 no 2900 0.158253146716531 4044 1247112
SGTC_22 0964-0034 14.468 µM -1.00339999941332 0.143898514054288 no 2901 0.157833952197663 4116 138402
SGTC_2067 5224629 34.075 µM -1.00427504452082 0.143692188284367 no 2902 0.157623029433838 4109 2835000
SGTC_119 0121-0043 24.815 µM -1.00531641964136 0.143446904056185 no 2903 0.157372255571626 4095 1092378
SGTC_2007 4011539 71.82 µM -1.00561433331943 0.143376785863247 no 2904 0.157300563158433 4064 45595301
SGTC_2023 5144124 124 µM -1.00805448264658 0.142803333398823 no 2905 0.156714153733066 4073 2830192
SGTC_1419 3993-2473 62.6 µM -1.00837862796049 0.142727273757497 no 2906 0.156636364496771 4160 704026
SGTC_2384 9036245 200 µM -1.01156415402345 0.14198125760137 no 2907 0.155873246175332 4037 6462766
SGTC_1239 0337-0584 35.4 µM -1.01315696073459 0.141609231021043 no 2908 0.15549259725304 4170 914301 YML130C ERO1
SGTC_810 3825-7150 143 µM -1.01564424956204 0.141029605114059 no 2909 0.154899412591755 4171 22330411 YGL099W LSG1
SGTC_3204 9114183 49.47 µM -1.01630665438685 0.140875513157922 no 2910 0.154741690385909 4088 17027248
SGTC_1641 st009299 47.1 µM -1.01684859708989 0.140749528690041 no 2911 0.154612729813869 4011 4046054
SGTC_2913 7966556 36.57 µM -1.01841009776404 0.140386956962686 no 2912 0.154241552703739 3973 2976516
SGTC_1924 st058459 75.1 µM -1.01932917441014 0.140173849253672 no 2913 0.154023358977428 4073 688683
SGTC_2588 indole-3-carbinol 100 µM -1.01937795387893 0.140162544827925 no 2914 0.154011784179694 4161 3712 Induces cell cycle arrest.
SGTC_2755 lomerizine 42.69 µM -1.02040009799165 0.139925809906129 no 2915 0.153769373714323 4077 3949 A calcium channel blocker.
SGTC_441 propafenone 146 µM -1.02050800257474 0.139900834401753 no 2916 0.153743797940223 4095 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_948 3448-0295 75.3 µM -1.02179968765302 0.139602097266274 no 2917 0.153437858617896 4094 678569
SGTC_2399 5884133 200 µM -1.02572157627447 0.138697713887502 no 2918 0.15251142055786 4121 722445
SGTC_1512 0259-0544 12.2 µM -1.02619096390944 0.138589741607204 no 2919 0.15240078989695 4081 18476
SGTC_155 k072-0202 43.6 µM -1.02719360609593 0.138359297720409 no 2920 0.152164654129352 4048 5857737
SGTC_1854 st056233 32.9 µM -1.02763913449056 0.138256982840472 no 2921 0.152059804182578 4039 5393174
SGTC_2696 st077691 74.316 µM -1.02784049801833 0.138210756958529 no 2922 0.152012431356617 4184 757133
SGTC_2352 9027995 87.8 µM -1.02797988010927 0.13817876597519 no 2923 0.151979646038196 4078 2997347
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.02981572682681 0.137757873540772 no 2924 0.151548258343014 4162 688798
SGTC_2525 harmine 47.85 µM -1.03241241574247 0.137164043005767 no 2925 0.150939479052547 4110 5280953 A monoamine oxidase inhibitor
SGTC_1415 3966-0071 78.1 µM -1.03308943625808 0.137009504635029 no 2926 0.150781023234073 4052 2893185
SGTC_1833 st055984 71 µM -1.03649148188068 0.136234746680168 no 2927 0.149986455657977 4141 676288
SGTC_1090 efavirenz 20.7 µM -1.03658885066684 0.136212616815358 no 2928 0.149963755783444 4157 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_775 4577-0580 57.3 µM -1.03811938463107 0.1358650820638 no 2929 0.149607238884444 4184 2006902
SGTC_2998 9066762 71.4286 µM -1.03998175550921 0.135443017448099 no 2930 0.149174188511753 4200 4945196
SGTC_331 k048-0133 24.5 µM -1.04038476902465 0.135351801853416 no 2931 0.149080587522135 4096 6813582
SGTC_2978 9011784 42.97 µM -1.04043565409846 0.135340287833955 no 2932 0.149068772114664 4113 2994934
SGTC_509 pifithrin 175 µM -1.04152232779674 0.135094561005685 no 2933 0.148816598071248 4191 4817 A p53 inhibitor.
SGTC_2685 mycophenolic acid 18.85 µM -1.04199036967245 0.134988818179096 no 2934 0.148708071928339 4106 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2408 sulbentine 18.36 µM -1.04437451486587 0.13445105899653 no 2935 0.148156074927293 4086 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1332 1480-0653 17.5 µM -1.04503908767012 0.134301422845298 no 2936 0.148002452203247 4130 5749438
SGTC_1374 2889-5571 141 µM -1.04514653739207 0.134277240058859 no 2937 0.14797762412975 4175 2853281
SGTC_2099 5377090 177.372 µM -1.04567316552887 0.134158759633398 no 2938 0.147855978120222 4146 2243829
SGTC_1175 0741-0056 27.6 µM -1.04648412257637 0.133976451564578 no 2939 0.147668785845641 4227 765927
SGTC_3018 9082602 49.47 µM -1.04697786833249 0.133865537933453 no 2940 0.147554892858262 4092 17332089
SGTC_2033 5192550 145 µM -1.04809850866675 0.133614034718303 no 2941 0.14729661166917 4150 182073
SGTC_587 k089-0003 57 µM -1.04977248668311 0.133238952461037 no 2942 0.146911363871359 4015 9659696
SGTC_211 3455-0679 143.504 µM -1.0509088470315 0.132984745498806 no 2943 0.146650228360522 4199 748649
SGTC_902 1120-0002 2.07 µM -1.05164788505011 0.132819599937341 no 2944 0.146480564746894 4123 3280475
SGTC_2878 9043973 25.97 µM -1.05173096108671 0.132801044585885 no 2945 0.146461500924231 4195 6465167
SGTC_543 3844-1095 191 µM -1.05240132035091 0.132651382592726 no 2946 0.146307731586835 4144 4230703
SGTC_347 4534-1311 26.2 µM -1.05395332388864 0.132305333866911 no 2947 0.145952143777161 4143 2862016
SGTC_2980 9014342 25.29 µM -1.05428378221276 0.132231732316773 no 2948 0.145876505757888 4209 2996599
SGTC_595 3909-8003 73.7 µM -1.05527373804404 0.132011412698201 no 2949 0.145650074210037 4220 699517
SGTC_296 1222-0039 74.9 µM -1.05815223115458 0.131372228469793 no 2950 0.144993022611593 4158 5984176
SGTC_1023 4482-3888 16 µM -1.05847205564401 0.131301341920599 no 2951 0.144920142080098 4179 3303168
SGTC_1624 st003710 6.25 µM -1.06008664467098 0.130943884408456 no 2952 0.144552591537517 4194 24207033
SGTC_1938 st074717 56.4 µM -1.06126195047287 0.130684104078634 no 2953 0.144285436236549 4046 17250979
SGTC_1714 st033236 13.627 µM -1.06242432655004 0.130427532288192 no 2954 0.144021547495191 4210 2916566
SGTC_188 3229-0966 278.469 µM -1.06559010966587 0.129730514979109 no 2955 0.143304486020413 4201 5722370
SGTC_603 3794-0023 45.9 µM -1.06976014765909 0.128816331784882 no 2956 0.142363642435252 4211 3802260
SGTC_300 r073-0011 5.04 µM -1.07085800927168 0.128576396273158 no 2957 0.1421166394826 4146 2735780
SGTC_874 0599-0792 117 µM -1.07114266307833 0.128514236405582 no 2958 0.142052643882302 4196 765305
SGTC_1708 st033234 31.827 µM -1.07131881417559 0.128475780729661 no 2959 0.142013051530901 4261 674664
SGTC_2932 9016711 44.54 µM -1.07346516130186 0.128007851651649 no 2960 0.141531230917679 4180 7117328
SGTC_1351 1496-0003 46.5 µM -1.07510808384804 0.127650476017901 no 2961 0.141163170322426 4188 3891978
SGTC_2084 5306078 60.6385 µM -1.07544492915536 0.127577289730742 no 2962 0.141087787797666 4093 679340
SGTC_1058 3448-5425 97.3 µM -1.08284364791586 0.125977126429093 no 2963 0.13943891403113 4099 7279705
SGTC_3301 9125354 19.7965 µM -1.0829975857282 0.125943982703062 no 2964 0.139404747325831 4151 41905162
SGTC_2216 7189485 200 µM -1.08451130325926 0.125618394181556 no 2965 0.139069079022205 4186 731273
SGTC_693 4161-2696 114 µM -1.08627328707468 0.125240145807866 no 2966 0.138679050880891 4209 805759
SGTC_628 1636-0253 16 µM -1.08690430130031 0.125104878389657 no 2967 0.138539552600698 4180 4456143
SGTC_399 oxolinic acid 75 µM -1.08904511301251 0.124646723528156 no 2968 0.138066996079656 4157 4628 A DNA gyrase inhibitor.
SGTC_557 1315-0110 16.2 µM -1.08913580140348 0.124627341242483 no 2969 0.138047002088023 4192 6833801
SGTC_3185 9108267 49.47 µM -1.09451869029326 0.123480660497932 no 2970 0.136863777362056 4207 4910486
SGTC_2298 7976326 193.81 µM -1.09457998179533 0.123467646672737 no 2971 0.136850344776042 4067 2235818
SGTC_1269 0831-0796 3.05 µM -1.0958055164714 0.123207634521085 no 2972 0.136581946925027 4218 927758
SGTC_3296 9122258 64.045 µM -1.09665890785366 0.123026803902731 no 2973 0.136395262950022 4169 4730474
SGTC_896 0964-0007 44.5 µM -1.09679064328866 0.122998906215043 no 2974 0.136366460672021 4158 6756758
SGTC_146 3448-8650 53.125 µM -1.09819700066109 0.1227013574962 no 2975 0.136059237829469 4169 2891488 YIL048W NEO1
SGTC_522 1273-0010 11.6 µM -1.09955327010631 0.122414884672605 no 2976 0.135763405938877 4283 5705015
SGTC_1405 3909-7894 12 µM -1.10005814183541 0.122308365053158 no 2977 0.135653395026005 4190 7104060
SGTC_378 3970-0959 8.33 µM -1.10052289480198 0.122210367358148 no 2978 0.135552179935026 4221 6615653
SGTC_2824 7998404 51.95 µM -1.10206001023274 0.121886644286523 no 2979 0.13521779163317 4165 837851
SGTC_3098 9119039 49.47 µM -1.10597857376075 0.121064104712927 no 2980 0.13436789670582 4193 17161528
SGTC_463 ikarugamyin 104 µM -1.11109756275425 0.119995479396544 no 2981 0.133263178428705 4336 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2634 4'-methoxyflavone 100 µM -1.11138990192858 0.119934652842022 no 2982 0.133200278512256 4219 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_108 0509-0257 621.132 µM -1.11170152619611 0.119869837605393 no 2983 0.133133251700025 4165 536624
SGTC_1448 4255-0083 152 µM -1.11826006798344 0.118511441848974 no 2984 0.131727968141509 4264 5399660
SGTC_1998 st075797 76.8 µM -1.11854534084668 0.118452604443853 no 2985 0.131667076537492 4200 24208315
SGTC_2774 tamoxifen 10.92 µM -1.12222783499787 0.117694944609644 no 2986 0.13088279024876 4196 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1258 0671-0043 57.1 µM -1.12410896564566 0.117309235156383 no 2987 0.130483401136222 4236 4298767
SGTC_230 MPP+ 141.667 µM -1.12442751353201 0.11724400842622 no 2988 0.130415852711502 4178 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2275 7947463 200 µM -1.1249813237286 0.117130669910218 no 2989 0.13029847424412 4186 1225414
SGTC_2455 5377712 9.75 µM -1.13028165971103 0.116049869451618 no 2990 0.129178780051673 4212 2243908
SGTC_1013 4112-3890 241 µM -1.13154600700427 0.115793103350131 no 2991 0.128912675380931 4157 705171
SGTC_246 cycloheximide 667 µM -1.13163979505996 0.115774072776434 no 2992 0.128892951152888 4113 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2428 5615643 7.78 µM -1.13183631705364 0.115734203620146 no 2993 0.128851628109089 4245 2253075
SGTC_2914 7968218 45.32 µM -1.13270841400584 0.115557395686247 no 2994 0.128668361545922 4185 2977111
SGTC_2071 5230951 39.92 µM -1.13500802829272 0.115092094960318 no 2995 0.128185977301822 4258 1799272
SGTC_250 brefeldin a 552.239 µM -1.14089312435708 0.113907384440117 no 2996 0.126957200506147 4109 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2947 9072639 7.68 µM -1.14096076295738 0.113893819020609 no 2997 0.126943125745732 4222 16488146
SGTC_3067 9117431 49.47 µM -1.14114633947277 0.113856606195707 no 2998 0.126904515134436 4257 17150885
SGTC_1689 st020265 53.493 µM -1.14207840042985 0.113669835242457 no 2999 0.126710716375946 4239 5758320 YPR016C TIF6
SGTC_2404 5161160 200 µM -1.14601895776604 0.112882620796109 no 3000 0.125893654012069 4178 2831543
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.1480524840822 0.112477904257795 no 3001 0.125473449000391 4245 5379071
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.14807866125428 0.112472701190268 no 3002 0.125468046175614 4267 61125 An anti-inflammatory.
SGTC_1740 st038286 13.222 µM -1.14821423945717 0.1124457559374 no 3003 0.125440066176203 4279 716786
SGTC_2876 9059903 25.97 µM -1.1496419236159 0.112162293291936 no 3004 0.125145691734923 4232 6916095
SGTC_1350 1495-0454 146 µM -1.15206780864436 0.111681812640305 no 3005 0.124646605058014 4279 1069057
SGTC_2130 NSC 7 2.4545 µM -1.15256078583225 0.111584351858471 no 3006 0.124545353281541 4314 21448
SGTC_1247 0448-0043 5.84 µM -1.15335164519999 0.111428127404764 no 3007 0.124383040111189 4268 3089013 YGL099W LSG1
SGTC_2438 5259590 200 µM -1.15466854642681 0.111168337377728 no 3008 0.124113092329144 4257 1201127
SGTC_1033 k072-0102 21.3 µM -1.15922698004412 0.110272427683126 no 3009 0.123181838357081 4213 5965931
SGTC_2960 9079389 5.97 µM -1.15925053791309 0.11026781113326 no 3010 0.123177038413709 4251 16457355
SGTC_1245 0418-0076 17.2 µM -1.16214417903297 0.109701808541576 no 3011 0.122588452266648 4283 6790114
SGTC_2022 5136654 200 µM -1.16633920229158 0.108884961030319 no 3012 0.121738664583671 4279 1713771
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.1670764507806 0.108741858253656 no 3013 0.12158974850797 4209 688761
SGTC_804 1595-0054 20.9 µM -1.16759913372767 0.108640485441031 no 3014 0.121484249898672 4201 761523 Stimulates phospholipase C.
SGTC_2718 lomofungin 53.02 µM -1.17235682216517 0.107720869864387 no 3015 0.120526913553916 4234 5351222 A RNA synthesis inhibitor.
SGTC_2134 5324836 1.464 µM -1.17436955840912 0.107333519969233 no 3016 0.120123516495735 4207 699272
SGTC_2552 juarezic acid 87.02 µM -1.1766501482732 0.106895836414307 no 3017 0.119667586516828 4217 1549512
SGTC_433 pimozide 108 µM -1.18183044245738 0.105906438400171 no 3018 0.118636492992246 4186 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2457 5731572 11.68 µM -1.19134073362415 0.104107303758798 no 3019 0.116759924538477 4325 2865357
SGTC_2186 6124449 200 µM -1.19602429100398 0.103229467309035 no 3020 0.115843539971893 4283 3834182 YLR033W RSC58
SGTC_1008 4106-0037 6 µM -1.19952309803533 0.102577204017911 no 3021 0.115162304433265 4297 2905394
SGTC_2326 6164455 177.58 µM -1.2073523814909 0.101128497942866 no 3022 0.113648232890473 4252 2888790
SGTC_1649 st011737 51.3 µM -1.2086042752557 0.100898241097203 no 3023 0.113407456570037 4291 1761035
SGTC_3100 9120536 49.47 µM -1.20982715887681 0.100673689277688 no 3024 0.113172611236332 4165 16421196
SGTC_3165 9101544 49.47 µM -1.21069741299842 0.10051411113952 no 3025 0.113005697130481 4296 5002184
SGTC_953 1188-0045 9.7 µM -1.21596290981044 0.0995525141656523 no 3026 0.111999525690774 4301 6144426
SGTC_83 0170-0301 39.027 µM -1.21654612328781 0.0994464213687507 no 3027 0.111888476058516 4303 3089716
SGTC_1999 st074831 12.5 µM -1.21690062990699 0.0993819732040867 no 3028 0.111821012970816 4278 17112523
SGTC_3239 9133757 49.47 µM -1.21977562679101 0.0988604355702035 no 3029 0.111274971675395 4334 17036923
SGTC_1309 pyrazolanthrone 13.4 µM -1.22142518482401 0.0985621037716343 no 3030 0.110962538215168 4269 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1355 1499-0035 1.68 µM -1.22175813259621 0.098501968326449 no 3031 0.110899552748235 4300 1548538
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.22249497225604 0.0983689793635433 no 3032 0.110760252016527 4262 676296 Flavone; oxidizing agent.
SGTC_3207 9114163 49.47 µM -1.22328516148577 0.0982265077350885 no 3033 0.110611004834689 4321 849233
SGTC_2309 7664088 163.95 µM -1.22618457404503 0.0977050365949845 no 3034 0.110064612475935 4314 704922
SGTC_2899 9053889 58.44 µM -1.22718592718425 0.0975254115373981 no 3035 0.109876358753688 4290 6470052
SGTC_2355 9061122 103.12 µM -1.22851344836056 0.0972876512295732 no 3036 0.109627142058152 4314 5302957
SGTC_549 1661-1316 519 µM -1.2288395796475 0.0972293059331274 no 3037 0.109565979298493 4342 2857282
SGTC_1105 epirubicin 18.1 µM -1.23454541851004 0.0962126749195862 no 3038 0.108499866671021 4339 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_657 3534-0529 86.7 µM -1.23589146631236 0.0959739876550965 no 3039 0.108249454753962 4351 1049549
SGTC_1697 st025554 27.742 µM -1.23678365181721 0.0958160214441897 no 3040 0.108083706469248 4318 1269519
SGTC_1472 k841-0093 193 µM -1.23838619952667 0.0955327622457456 no 3041 0.107786447633589 4436 X1472
SGTC_734 2023-0417 80 µM -1.2388918739315 0.0954435095286891 no 3042 0.107692771716542 4327 3935732
SGTC_1460 k062-0059 9.15 µM -1.24086962874603 0.0950950206200495 no 3043 0.107326957000887 4199 1373085
SGTC_389 tpck 16.7 µM -1.24296731655694 0.0947264240898585 no 3044 0.106939938772161 4369 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3198 9112019 49.47 µM -1.24321537933715 0.094682905298759 no 3045 0.106894238453139 4369 45595555
SGTC_152 4469-0003 551.229 µM -1.25151694836296 0.093235009118779 no 3046 0.105372967063256 4309 697280
SGTC_213 1246-0773 967 nM -1.25882154608831 0.0919745851288291 no 3047 0.104047398062442 4350 6251622
SGTC_1837 st055472 66.5 µM -1.25889372269733 0.0919621941691075 no 3048 0.104034360739838 4389 676091
SGTC_448 monastrol 171 µM -1.26257032073165 0.0913326463463024 no 3049 0.103371819807972 4260 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_531 3788-1495 174 µM -1.26635256430622 0.0906883486160564 no 3050 0.102693442859442 4318 2896655
SGTC_1144 3486-0183 12.5 µM -1.26828803178733 0.0903599532023992 no 3051 0.102347554742589 4350 6744069
SGTC_2682 pyrogallin 40.03 µM -1.26980806162541 0.0901026658244382 no 3052 0.102076504202821 4350 822798 An ATP competetive kinase inhibitor.
SGTC_1650 st011916 45.8 µM -1.27066615433176 0.0899576615907031 no 3053 0.10192372061317 4264 242528
SGTC_3319 9138450 16.7555 µM -1.27155588235635 0.0898074946807871 no 3054 0.101765480164649 4273 2029690
SGTC_1495 4469-0029 237 µM -1.27235615156025 0.0896725857335438 no 3055 0.101623303044592 4348 793680
SGTC_2949 9072542 2.23 µM -1.27326162901433 0.0895201225952815 no 3056 0.101462608932888 4357 16457352
SGTC_1097 itavastatin 7.23 µM -1.27340284295122 0.0894963625601012 no 3057 0.101437564539164 4360 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2458 5808907 16.39 µM -1.27645643047812 0.0889837259900423 no 3058 0.100897109560869 4488 2731747
SGTC_2116 5511452 16.8835 µM -1.27700531240921 0.088891811861182 no 3059 0.100800185870443 4358 870744
SGTC_1346 1488-2224 62.4 µM -1.27790453682171 0.0887413832131413 no 3060 0.100641544111185 4363 3722427
SGTC_1795 st049545 62.3 µM -1.27864445584682 0.0886177465406628 no 3061 0.100511143753566 4291 5291882
SGTC_1064 honokiol 6.76 µM -1.27949778593037 0.0884753188258104 no 3062 0.100360909395733 4374 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1793 st048256 72.231 µM -1.27951107448252 0.0884731022080517 no 3063 0.100358571155527 4297 672022
SGTC_2483 5729050 27.16 µM -1.28149538115054 0.0881425710154081 no 3064 0.100009860622428 4369 2865180
SGTC_3124 9127567 49.47 µM -1.28203423728792 0.0880529714623451 no 3065 0.0999153181109487 4328 17592030
SGTC_1888 azatryptophan 97.5 µM -1.28486821763506 0.0875828622997691 no 3066 0.0994191694297383 4397 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3314 9135860 59.4275 µM -1.28671560651906 0.0872774218327658 no 3067 0.0990967157019735 4342 25252478
SGTC_797 k781-0471 270 µM -1.28674833442634 0.087272017899674 no 3068 0.099091010091225 4326 23738129
SGTC_13 0199-0087 65 µM -1.28697070311894 0.0872353076681985 no 3069 0.099052249868263 4453 4589825
SGTC_3333 9141820 12.094 µM -1.28931085043312 0.0868496781011265 no 3070 0.0986450201486024 4337 1939433
SGTC_696 1560-0013 611 µM -1.29182832944265 0.0864362499317798 no 3071 0.0982083011362089 4403 1650269
SGTC_51 1013-0126 23.419 µM -1.29535091603313 0.0858602323037817 no 3072 0.0975996011063838 4373 1627850
SGTC_2219 9098279 200 µM -1.29765894805129 0.0854843810243411 no 3073 0.097202278087773 4306 902349
SGTC_1492 4158-0558 28.5 µM -1.29816874431152 0.0854015296849826 no 3074 0.0971146779601954 4375 3967268
SGTC_2923 7992654 58.14 µM -1.29880597491141 0.0852980525005816 no 3075 0.0970052618251109 4354 2985126
SGTC_3041 9091929 49.47 µM -1.301048875832 0.0849345843970152 no 3076 0.0966208627324867 4367 25236887
SGTC_46 0329-0187a 2.197 µM -1.30231755444411 0.0847295063931793 no 3077 0.0964039265778539 4399 46494817
SGTC_744 1594-0068 283 µM -1.30470057006123 0.0843453033926556 no 3078 0.0959974136525026 4348 668392
SGTC_348 k064-0012 10.7 µM -1.30805243444392 0.0838071118837109 no 3079 0.0954277625816871 4295 5066323
SGTC_220 paclitaxel 373.376 µM -1.30809075872437 0.0838009733019965 no 3080 0.0954212637692018 4327 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3234 9132280 49.47 µM -1.30974239961615 0.0835367429436777 no 3081 0.0951414974179927 4384 17612295
SGTC_986 1493-0483 84 µM -1.30997052964322 0.083500295848941 no 3082 0.0951029027068546 4320 40079
SGTC_1524 corynanthine 62.1 µM -1.31059446721803 0.0834006737726894 no 3083 0.0949974047392223 4450 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1091 telmisartan 47.6 µM -1.31452260957376 0.0827755308768419 no 3084 0.0943351972840459 4411 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3323 9138564 53.9225 µM -1.31553761778713 0.0826145724322394 no 3085 0.0941646416775095 4383 43912313 YNL103W MET4
SGTC_198 3454-2873 16.191 µM -1.3183067274873 0.0821766493760079 no 3086 0.0937004948983289 4389 710957
SGTC_833 3852-0053 558 µM -1.32539267276724 0.0810640012577602 no 3087 0.0925204729961598 4446 3123681
SGTC_640 3381-0960 37.1 µM -1.32764257230282 0.0807131066841778 no 3088 0.0921481067253144 4441 1745025
SGTC_1125 tnp00248 1.32998 µM -1.32785310921256 0.0806803301036056 no 3089 0.0921133189763061 4422 24207736
SGTC_2444 5485484 36.41 µM -1.33198165427034 0.0800396239065965 no 3090 0.091433108530634 4450 6790631
SGTC_1992 st073643 23.3 µM -1.33381464709225 0.0797563991118188 no 3091 0.0911323047479913 4375 3161292
SGTC_2725 haloperidol 53.21 µM -1.33407097135157 0.0797168536739046 no 3092 0.0910902991438736 4349 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.33429701954773 0.0796819915049485 no 3093 0.0910532670019764 4394 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_162 k030-0015 37.8 µM -1.33490001090452 0.0795890518876597 no 3094 0.0909545371114154 4443 1809920 YMR134W ERG29
SGTC_2623 humulene 100 µM -1.34337200812273 0.0782919127638683 no 3095 0.0895757730459374 4380 6187145 An anti-inflammatory.
SGTC_773 4358-1457 44.6 µM -1.34669491845987 0.077787545376606 no 3096 0.0890392547757757 4392 1186886
SGTC_1764 st044502 93.5 µM -1.35105979570744 0.077128775479626 no 3097 0.0883381394420007 4420 8407
SGTC_217 ketoconazole 989 nM -1.35315056802147 0.0768147308793608 no 3098 0.0880037667513471 4220 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1470 k295-0292 231 µM -1.35366243848626 0.0767379936871395 no 3099 0.0879220484086958 4476 5045612
SGTC_573 3702-0553 84.7 µM -1.35524726819679 0.0765007731606678 no 3100 0.087669394697262 4348 1222756
SGTC_1810 st050138 53 µM -1.35557841218936 0.0764512773877648 no 3101 0.0876166721718925 4408 3444541
SGTC_2285 7945142 200 µM -1.35583425328224 0.0764130537520054 no 3102 0.0875759550715683 4430 2970608
SGTC_2586 curcumin 80 µM -1.35738076854267 0.0761823079974553 no 3103 0.0873301278246339 4298 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_892 0929-0076 29 µM -1.35918376873988 0.0759139637651799 no 3104 0.0870441816612537 4380 5751038
SGTC_508 roscovitine 141 µM -1.36195536422287 0.0755028659746226 no 3105 0.0866059860610007 4484 160355 A CDKinase inhibitor.
SGTC_3287 9117173 37.0625 µM -1.36304223853893 0.0753421188627987 no 3106 0.0864345995553496 4422 2789709
SGTC_2665 lovastatin 100 µM -1.36366019110079 0.0752508409845471 no 3107 0.0863372692983682 4431 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3092 9117248 49.47 µM -1.36502722729854 0.0750492154047491 no 3108 0.0861222463043076 4535 17141857
SGTC_2255 7941087 197.44 µM -1.36534589686396 0.0750022737702435 no 3109 0.0860721799597691 4504 935561
SGTC_3097 9117246 49.47 µM -1.36707731487476 0.0747476184484388 no 3110 0.0858005364691846 4439 16423892
SGTC_1792 st045773 43.6 µM -1.36800257012961 0.0746118035414823 no 3111 0.0856556358096017 4379 2919270
SGTC_57 miconazole 162.5 nM -1.36989238131307 0.0743349902235337 no 3112 0.0853602491521498 4254 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_128 0906-2981 13.371 µM -1.37170285425876 0.0740705342766199 no 3113 0.0850779797565474 4403 6740226
SGTC_79 0052-0007 94.094 µM -1.3768262810198 0.0733260496654668 no 3114 0.0842829816991109 4402 2801472
SGTC_1568 digitonin 820 nM -1.37854081073997 0.0730781939498844 no 3115 0.0840181883500655 4393 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_499 genistein 192 µM -1.37897971603231 0.073014848143539 no 3116 0.0839505039858111 4505 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_85 0868-0259 160.055 µM -1.3790313030828 0.0730074055092931 no 3117 0.0839425513450023 4344 83173
SGTC_2783 7738165 71.43 µM -1.38010439707373 0.0728527183235836 no 3118 0.0837772518220563 4403 17201110
SGTC_927 2425-1185 123 µM -1.38087122884988 0.0727423328374233 no 3119 0.0836592788393218 4367 730375
SGTC_689 0833-0039 98 µM -1.3819224020004 0.0725912245551366 no 3120 0.083497764321308 4384 5374726
SGTC_1142 3253-1408 9.78 µM -1.39200018529422 0.0711547005500598 no 3121 0.0819611709223766 4445 256655
SGTC_2757 clomiphene 4.22 µM -1.39361565301074 0.0709264699395083 no 3122 0.0817168495592668 4440 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1840 st055363 71 µM -1.39711537396652 0.0704339642580007 no 3123 0.0811894396780989 4460 676033
SGTC_3339 9145883 14.936 µM -1.39991791100029 0.0700414704516044 no 3124 0.0807689509179353 4351 2030670
SGTC_3011 9081274 71.4286 µM -1.40111248924442 0.0698746827795544 no 3125 0.0805902187209437 4432 6625322
SGTC_1289 0976-0073 69.1 µM -1.4045631419873 0.0693946172071638 no 3126 0.0800756116339899 4491 3391136
SGTC_3324 9138759 60.749 µM -1.40475684222879 0.0693677445158778 no 3127 0.0800467982950163 4468 45595710
SGTC_204 PMA1.184 62.41 µM -1.40704502372259 0.0690509036479802 no 3128 0.0797070192167088 4404 2252213 YGL008C PMA1
SGTC_1821 st053465 65.6 µM -1.4086246416143 0.0688328280057164 no 3129 0.079473094259804 4457 675086
SGTC_3285 9112818 20.8695 µM -1.40928893327513 0.0687412773519688 no 3130 0.0793748749167825 4415 17017947 YPR165W RHO1
SGTC_1476 4112-3294 3.34 µM -1.40930721504652 0.0687387591421225 no 3131 0.0793721731514117 4444 704369
SGTC_3271 9137798 49.47 µM -1.41011801009136 0.0686271482636468 no 3132 0.0792524200695293 4430 6498326
SGTC_2247 cerulenin 830 nM -1.41310794689798 0.0682167729985709 no 3133 0.0788119934851162 4462 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1813 st051246 8.6015 µM -1.41414510837075 0.0680748636494301 no 3134 0.0786596505031324 4396 5291959
SGTC_1872 amphotericin b 148 nM -1.41613316544503 0.0678034854921042 no 3135 0.0783682596978401 4449 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1078 idebenone 36.1 µM -1.41774432796812 0.067584168632082 no 3136 0.078132711599631 4478 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_109 0132-0036 33.701 µM -1.41775939210563 0.0675821206405483 no 3137 0.0781305117957351 4329 67274 A color developer.
SGTC_2883 9059145 45.46 µM -1.42193400897524 0.0670164211056539 no 3138 0.077522704585455 4433 16476510
SGTC_1403 3909-7815 62.9 µM -1.42308561048376 0.0668610146461537 no 3139 0.0773556695952534 4428 6615483
SGTC_3004 9076122 71.4286 µM -1.42326191781342 0.0668372469328586 no 3140 0.0773301211018046 4457 44782551
SGTC_70 0141-0289 43.283 µM -1.42573495366362 0.0665045493749098 no 3141 0.0769724314927851 4406 352408
SGTC_1229 0139-0193 12.2 µM -1.42579479913264 0.0664965142793138 no 3142 0.0769637913038589 4509 3090752
SGTC_2920 7982904 15.77 µM -1.42662746912393 0.0663847945849984 no 3143 0.0768436510560769 4449 6456808
SGTC_110 0850-0284 111.64 µM -1.42719371409579 0.0663089043104098 no 3144 0.0767620329309095 4363 3906265
SGTC_1133 3473-0247 50 µM -1.43406076636729 0.065393895676555 no 3145 0.0757774613594542 4427 711311
SGTC_3256 9138902 49.47 µM -1.43519011742557 0.0652443562190023 no 3146 0.0756164644923527 4556 17228773
SGTC_703 3875-0075 71.8 µM -1.44166998896947 0.0643914673109143 no 3147 0.0746977468838217 4502 2850814
SGTC_2164 5685496 200 µM -1.44668194797266 0.0637377486381428 no 3148 0.0739930113342955 4376 759046
SGTC_1034 k072-0165 12.7 µM -1.4469255164438 0.0637061116067024 no 3149 0.0739588928585468 4479 5835461
SGTC_634 1611-4317 11.2 µM -1.449726314769 0.063343194159836 no 3150 0.0735674272687524 4494 2843522
SGTC_1368 1852-0141 284 µM -1.45239781009565 0.0629985329964369 no 3151 0.0731955124362754 4450 2838987
SGTC_3038 9091290 49.47 µM -1.45668211318029 0.0624488485691456 no 3152 0.0726020747308391 4468 25236843
SGTC_1507 4075-3230 155 µM -1.45695890004845 0.0624134652839168 no 3153 0.072563862858668 4431 659771
SGTC_484 loperamide 105 µM -1.45952411493982 0.0620862822238279 no 3154 0.0722104541645384 4566 3955 An opioid-receptor agonist.
SGTC_2088 5278280 127.392 µM -1.46508244922136 0.0613819308328868 no 3155 0.071449212217417 4515 791502
SGTC_2748 diazoxide 86.69 µM -1.46542223593643 0.0613390763974063 no 3156 0.0714028772287363 4560 3019 A potassium channel activatior.
SGTC_3347 9188721 44.724 µM -1.46651365752697 0.0612015826965583 no 3157 0.0712542016139945 4483 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2565 isoliquiritigenin 100 µM -1.47066479439153 0.0606808350836479 no 3158 0.0706908958045868 4502 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_431 k089-0097 107 µM -1.47227792776246 0.0604794099025107 no 3159 0.0704729205882873 4206 5499420
SGTC_1648 st011736 69.8 µM -1.47540951021035 0.0600898763251732 no 3160 0.0700512400445663 4468 2855514
SGTC_1691 st019933 84.6 µM -1.48265179340988 0.059196543413016 no 3161 0.069083474335118 4473 6176082
SGTC_558 k064-0027 21.3 µM -1.48369296352089 0.0590689762280237 no 3162 0.0689451969319591 4493 5088526
SGTC_2381 9035592 200 µM -1.48662076941356 0.058711408565793 no 3163 0.0685574995787236 4501 4749657
SGTC_1715 st032160 10.2275 µM -1.49242427241628 0.0580076606113348 no 3164 0.067793977923704 4402 5289825
SGTC_486 niguldipine 82 µM -1.49267712360953 0.0579771505867881 no 3165 0.0677608621795428 4571 1236 A calcium channel blocker.
SGTC_2207 7258803 200 µM -1.49763484566908 0.0573814766528333 no 3166 0.0671140741146874 4508 3666799
SGTC_786 4544-0069 423 µM -1.49818101976978 0.0573161489678518 no 3167 0.067043112777259 4478 748821 YLR208W SEC13
SGTC_130 0136-0219 337.655 µM -1.50016012268738 0.0570799193291674 no 3168 0.0667864650538189 4378 234244
SGTC_2897 9048598 12.99 µM -1.51085423379902 0.0558166829159731 no 3169 0.0654127966933161 4482 6467404
SGTC_2031 5180455 200 µM -1.51432872680217 0.0554110415546893 no 3170 0.0649712430696962 4489 29949
SGTC_2812 7970281 58.44 µM -1.51515499506215 0.0553149195103225 no 3171 0.0648665786172825 4521 2233435
SGTC_1392 3455-1037 33.9 µM -1.5174045777504 0.0550538866342161 no 3172 0.0645822844360352 4500 981132
SGTC_1059 3448-6867 171 µM -1.5236636592447 0.054332726323554 no 3173 0.0637963759679143 4473 3934407
SGTC_2010 4012422 159 µM -1.52382006911393 0.054314801229185 no 3174 0.0637768323895045 4460 952393
SGTC_3282 9108498 15.4605 µM -1.52730029886836 0.0539171642166 no 3175 0.0633431776045776 4486 16459645
SGTC_1184 1269-1718 139 µM -1.53146215902548 0.0534446768990599 no 3176 0.0628276059118675 4565 5403821
SGTC_1680 diphenhydramine 100 µM -1.53513571009208 0.053030357852284 no 3177 0.0623752481020079 4479 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_100 0086-0128 49.5915 µM -1.54320387573075 0.0521293360322266 no 3178 0.0613906586212233 4512 93297
SGTC_2521 angolensin 13.4 µM -1.5461760400652 0.0518004972346466 no 3179 0.0610310291903927 4545 821428 A flavenoid.
SGTC_228 caffeine 993.056 µM -1.55259915353617 0.0510954789813893 no 3180 0.0602594640085933 4523 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2763 lisinopril 49.32 µM -1.55966027542947 0.0503292654808114 no 3181 0.0594200921689714 4435 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1647 st011722 22.4 µM -1.56353039021061 0.049913214247279 no 3182 0.0589639466780679 4509 2854783
SGTC_2746 daunorubicin 9.88 µM -1.56564352069393 0.0496872055641062 no 3183 0.0587160476957176 4550 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2702 st077768 96.8 µM -1.5686194576915 0.0493703014239503 no 3184 0.0583683179179821 4493 6484119
SGTC_714 4296-0578 26.1 µM -1.56949985808604 0.0492768585245356 no 3185 0.0582657562550997 4585 1589775
SGTC_3019 9081971 49.47 µM -1.57550254149433 0.0486435110787028 no 3186 0.0575702461439743 4527 16451803
SGTC_3315 9136395 68.55 µM -1.58047706242531 0.0481235914808398 no 3187 0.0569988278843179 4524 16876844
SGTC_738 1315-0003 72.4 µM -1.58115753089699 0.0480528183167956 no 3188 0.0569210115530279 4547 6251474
SGTC_1963 st076565 50.3 µM -1.58494951237715 0.0476599516333834 no 3189 0.056488902876616 4548 4914280
SGTC_428 3448-4153 16.5 µM -1.58555028196348 0.0475979458732945 no 3190 0.0564206810638821 4493 3834874
SGTC_1804 st050076 49.1 µM -1.58626989702492 0.0475237590769087 no 3191 0.0563390489672545 4570 3895976
SGTC_2220 6782180 200 µM -1.58778678214534 0.0473676832687652 no 3192 0.0561672806827521 4492 833803
SGTC_96 0929-0093 37.281 µM -1.58996344596297 0.047144439177378 no 3193 0.0559215224329344 4543 6991579
SGTC_395 anisomycin 6.25 µM -1.5901441167959 0.0471259470988984 no 3194 0.0559011618112052 4553 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2657 nystatin 74.44 µM -1.59225037305528 0.0469107956584468 no 3195 0.0556642294322058 4565 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_286 k060-0067 22.9 µM -1.59371874930549 0.0467612694352504 no 3196 0.0554995214376 4567 5985051
SGTC_3169 9102970 49.47 µM -1.59736891859206 0.0463912253277202 no 3197 0.0550917482580716 4613 17027839
SGTC_2302 7771753 200 µM -1.60007351143498 0.0461185603018049 no 3198 0.0547911382293466 4525 2203047
SGTC_2821 7996764 71.43 µM -1.60797531892786 0.0453293032900067 no 3199 0.0539202921836471 4529 2987135
SGTC_1763 st044482 94.5 µM -1.61308500304076 0.0448247423637455 no 3200 0.0533630207890104 4535 88505
SGTC_3089 9117425 49.47 µM -1.61309747006651 0.0448235168475666 no 3201 0.0533616667161055 4528 9401657
SGTC_2791 5663188 71.43 µM -1.61316591206811 0.0448167894379462 no 3202 0.0533542335548842 4558 54690634
SGTC_1701 st028638 40.4 µM -1.61550894140483 0.0445869745719165 no 3203 0.0531002627980216 4564 3490878
SGTC_1962 st076595 64.5 µM -1.61784804288617 0.0443584928009849 no 3204 0.0528476748963762 4517 279619
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -1.61986701008413 0.0441620410398109 no 3205 0.0526304239179039 4547 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2080 5212524 12.4 µM -1.63250861110029 0.0429478670793653 no 3206 0.051286192971316 4524 260183
SGTC_1817 st052116 64.4 µM -1.64620347930927 0.0416631187399076 no 3207 0.0498609365939539 4585 4361398
SGTC_1212 0520-0165 585 µM -1.65309928520375 0.0410280907195533 no 3208 0.0491553293999223 4599 5403258
SGTC_877 0771-0151 33.1 µM -1.65365960681142 0.0409768379686561 no 3209 0.0490983471045809 4574 6166523
SGTC_2182 6325192 200 µM -1.65764374991058 0.0406139031301522 no 3210 0.0486946968022275 4596 736248
SGTC_1841 st054148 70 µM -1.65797373970311 0.0405839601363309 no 3211 0.0486613834501532 4585 675442
SGTC_81 0411-0046 9.971 µM -1.65889999887137 0.0405000078954494 no 3212 0.0485679724437859 4580 12925265
SGTC_722 3534-0461 190 µM -1.66023786717913 0.0403789980724563 no 3213 0.048433304794353 4586 658262
SGTC_345 1362-0200 395 µM -1.66479453003597 0.0399690504345358 no 3214 0.0479768778091349 4565 1419823
SGTC_2451 5856223 45.7 µM -1.67109397050264 0.0394078878229155 no 3215 0.0473515590740195 4564 2179896
SGTC_759 3486-0358 89.3 µM -1.67584237831412 0.0389891439467323 no 3216 0.0468845354065527 4554 875103
SGTC_1815 st051655 58.2 µM -1.67957169470235 0.0386628160106798 no 3217 0.0465203393679935 4546 5984156
SGTC_2272 7805186 180 µM -1.67972610732933 0.038649352501155 no 3218 0.0465053088950709 4580 2956062 YPR165W RHO1
SGTC_2336 9001819 198.65 µM -1.68079607477127 0.0385561650608364 no 3219 0.0464012656754996 4571 2989602
SGTC_2035 5154463 94.595 µM -1.6830026385757 0.038364565367544 no 3220 0.0461872903173225 4586 2769623
SGTC_1657 st012939 43.4 µM -1.6917101597308 0.037616038092218 no 3221 0.0453506251719005 4574 24207257
SGTC_541 4513-1321 94 µM -1.69866877864235 0.0370264612851642 no 3222 0.0446908046376378 4559 747515
SGTC_2771 fluoxetine 41.05 µM -1.70081319778896 0.03684630296942 no 3223 0.0444890351055434 4584 3386 A selective serotonin reuptake inhibitor.
SGTC_8 0354-0001 70 µM -1.70127974150416 0.0368072024870899 no 3224 0.0444452351123139 4582 4993152
SGTC_1619 st003326 88.7 µM -1.70170949340411 0.0367712155123333 no 3225 0.0444049199521849 4570 2849032
SGTC_1100 amiodarone 5.07 µM -1.70398136203352 0.0365814494534652 no 3226 0.0441922846383725 4618 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2056 5235370 200 µM -1.70650854966329 0.0363712990605979 no 3227 0.0439567179268572 4513 5511916
SGTC_3250 9135583 49.47 µM -1.70936275893925 0.0361351441386523 no 3228 0.0436918873893061 4596 7699353
SGTC_1177 0983-0204 23.6 µM -1.71672250117431 0.0355319935703585 no 3229 0.0430149434274284 4632 766818
SGTC_122 0236-0016 402.397 µM -1.7204935482312 0.0352261588568396 no 3230 0.0426713827196957 4578 6808838
SGTC_53 0973-0023 39.979 µM -1.7237926694669 0.0349603718071073 no 3231 0.0423726392230697 4526 674768
SGTC_602 3130-1533 38.1 µM -1.73746781046224 0.0338761577809665 no 3232 0.0411523155158706 4633 720941
SGTC_2353 9059630 146.67 µM -1.73848285675114 0.0337967963323578 no 3233 0.0410628841098118 4639 4779114
SGTC_332 4112-0506 40.9 µM -1.74350234038446 0.0334065931072347 no 3234 0.0406229529189101 4609 2790355
SGTC_1170 0310-0127 64.8 µM -1.74397690110763 0.0333698945505992 no 3235 0.0405815588695069 4618 774975
SGTC_564 3555-0129 330 µM -1.74908364709441 0.0329770783077912 no 3236 0.0401382807498128 4546 563260
SGTC_3127 9126946 49.47 µM -1.74999101355421 0.032907683010376 no 3237 0.0400599321963624 4557 27243249
SGTC_3145 9085516 49.47 µM -1.75145092508493 0.0327962817752799 no 3238 0.0399341337729816 4586 25236195
SGTC_743 1275-0778 158 µM -1.75681107492585 0.0323899288979877 no 3239 0.0394750083709961 4590 2849257 YMR203W TOM40
SGTC_2787 5284540 71.43 µM -1.75881664952269 0.0322389582458709 no 3240 0.039304327952441 4605 736958
SGTC_1012 4112-3522 18 µM -1.76276285435177 0.0319436012170507 no 3241 0.0389702473970719 4610 3112398
SGTC_5 0352-0601 109.883 µM -1.76602453454797 0.0317011681247559 no 3242 0.0386958664144443 4531 762456
SGTC_2038 4100038 30.985 µM -1.76987926694771 0.0314166169843784 no 3243 0.0383736276780076 4576 3596803
SGTC_737 1950-0117 57.9 µM -1.77966758914218 0.0307035345567416 no 3244 0.037565188837947 4615 5393513
SGTC_1228 0124-0032 52.5 µM -1.7847679833695 0.0303373125994158 no 3245 0.0371494792867811 4629 X1228
SGTC_2592 piperlongumine 83.33 µM -1.78500624382946 0.030320293738522 no 3246 0.037130152058128 4603 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1330 1469-0054 61.8 µM -1.80600523430288 0.028851123233741 no 3247 0.0354587609829057 4593 7102664
SGTC_2149 5554786 194.827 µM -1.81064673962533 0.0285345001520895 no 3248 0.0350977760997737 4660 745063 YPR165W RHO1
SGTC_1317 1273-0028 910 nM -1.81262620134562 0.028400351932372 no 3249 0.0349447469052522 4642 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2761 levamisole 97.89 µM -1.82083344119981 0.0278497332279965 no 3250 0.0343160896182915 4628 26879 An alkaline phosphatase inhibitor.
SGTC_2924 9010168 62.78 µM -1.82291317056455 0.0277116265821932 no 3251 0.0341582714140436 4612 2993929
SGTC_1540 guanosine 70.6 µM -1.82767236522641 0.0273977335646524 no 3252 0.0337993689845954 4593 6802 Guanosine is a purine nucleoside
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.8430729592265 0.0264022408955447 no 3253 0.0326591794017903 4615 756377
SGTC_2975 9084847 53.72 µM -1.84436744242461 0.0263199608288473 no 3254 0.0325648043869791 4611 27211724
SGTC_1020 4335-0961 93.3 µM -1.84559808437318 0.0262419374980567 no 3255 0.0324752924364794 4612 669075
SGTC_1143 3454-2408 5.08 µM -1.84596196250054 0.0262189045132735 no 3256 0.0324488643182119 4659 X1143
SGTC_1348 1493-0373 93.8 µM -1.85006344244143 0.0259604534796872 no 3257 0.0321522030923399 4651 3010129
SGTC_841 0251-0215 91.2 µM -1.85186052717145 0.0258478851728857 no 3258 0.0320229266991538 4675 3888614
SGTC_2048 5246248 200 µM -1.85501831609765 0.0256510726242731 no 3259 0.0317968055331106 4663 677046
SGTC_117 lucigenin 22.078 µM -1.85874198652635 0.0254206043615737 no 3260 0.0315318595234399 4592 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2541 muurolladie-3-one 83.07 µM -1.86056985165886 0.0253081089053871 no 3261 0.031402472808408 4577 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2259 7964009 200 µM -1.86758478468029 0.0248802413546785 no 3262 0.0309099844308007 4652 313134
SGTC_2813 7971799 71.43 µM -1.87685608192409 0.0243240712654792 no 3263 0.0302689107784574 4632 2234054
SGTC_2146 5545642 200 µM -1.87896829453516 0.0241988337086133 no 3264 0.0301244112634794 4625 825326
SGTC_3249 9135183 49.47 µM -1.88176939893011 0.0240335860391531 no 3265 0.0299336661903116 4603 4902779
SGTC_2778 tioconazole 65.09 nM -1.88633310188629 0.0237663872398051 no 3266 0.0296250406349666 4548 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2513 baicalein 25.65 µM -1.89055530797591 0.0235214111874404 no 3267 0.0293418654721991 4628 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3284 9108171 64.8615 µM -1.89200681158358 0.0234376858465403 no 3268 0.0292450366269109 4622 8687505
SGTC_176 1486-1328 72.834 µM -1.89489512197638 0.0232718286983257 no 3269 0.0290531487830947 4663 22310231
SGTC_2756 carbadox 75.1 µM -1.89565359022976 0.0232284388675505 no 3270 0.029002932967442 4575 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_983 1491-0821 12.2 µM -1.8960729931372 0.0232044752631583 no 3271 0.0289751965925078 4666 46495113
SGTC_2060 5238662 140 µM -1.89815714799602 0.0230857004764017 no 3272 0.0288376919266186 4631 790130
SGTC_3242 9133940 49.47 µM -1.9025588934865 0.0228365292929801 no 3273 0.0285490636225906 4659 17248444
SGTC_1546 5-methoxyflavanone 78.7 µM -1.90370739564032 0.0227718896396886 no 3274 0.0284741513578447 4690 147795
SGTC_2512 diallyl trisulfide 49.23 µM -1.90949409222329 0.0224485454070803 no 3275 0.02809919156001 4684 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1153 4055-0057 267 µM -1.91229291547433 0.0222935496154129 no 3276 0.0279193170068486 4695 882706
SGTC_1726 st035556 14.5795 µM -1.95558547400719 0.0200087473659675 no 3277 0.0252570027201219 4674 5919439
SGTC_2081 5214970 32.255 µM -1.96668844574652 0.0194558614092308 no 3278 0.0246095698754146 4641 2063512
SGTC_3345 9148410 3.559 µM -1.97420216860122 0.0190891148627135 no 3279 0.0241793797620654 4624 4903596
SGTC_1088 bifonazole 369 nM -1.97906508355831 0.0188549016050343 no 3280 0.0239043395238197 4683 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_411 enrofloxacin 100 µM -1.99930238737632 0.017906292546063 no 3281 0.0227878230125756 4716 71188 A bacterial gyrase inhibitor.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -2.00440668303395 0.0176735633000305 no 3282 0.0225132570064516 4663 1377
SGTC_2101 5377231 179.231 µM -2.00933360941722 0.0174513743537191 no 3283 0.0222508829300488 4708 2844213
SGTC_2798 7813637 45.45 µM -2.01193628119803 0.0173349678075736 no 3284 0.0221133271251871 4672 956368
SGTC_2177 5811945 192 µM -2.02249156831051 0.016869649029877 no 3285 0.0215627968960475 4668 5343475
SGTC_719 2810-4230 27.3 µM -2.0271691054455 0.0166668851313334 no 3286 0.0213225607591341 4714 721079
SGTC_2187 6125751 200 µM -2.03367819948467 0.0163881984035098 no 3287 0.020992025798062 4689 874498
SGTC_686 1319-0111 510 µM -2.03646226391874 0.0162702226295738 no 3288 0.0208519793382997 4697 4562600
SGTC_407 eburnamonine 100 µM -2.04248572368509 0.0160174636943039 no 3289 0.0205516870656263 4581 3195
SGTC_129 0088-0017 176.636 µM -2.05629368821427 0.0154507197093508 no 3290 0.0198771081626724 4579 182446
SGTC_1029 k015-0030 64.7 µM -2.07084715257907 0.0148720969364528 no 3291 0.0191865410748916 4712 2208316
SGTC_1263 0774-1208 64.8 µM -2.07214146760474 0.014821551154564 no 3292 0.0191261250577264 4671 906585
SGTC_111 0083-0039 52.457 µM -2.07693593169659 0.0146356021651864 no 3293 0.0189037364270557 4691 759313
SGTC_2835 9006588 71.43 µM -2.07722073685351 0.0146246196947048 no 3294 0.0188905953948926 4631 2345538
SGTC_1617 st002906 78 µM -2.07926049307148 0.014546171010298 no 3295 0.0187967071121458 4701 5150859
SGTC_180 1486-1293 102.781 µM -2.0830562269019 0.0144011514773928 no 3296 0.0186230493556256 4645 4140536
SGTC_3230 9131665 49.47 µM -2.09018958770804 0.0141319807061119 no 3297 0.0183003862497857 4727 15943720
SGTC_717 1532-0246 73.2 µM -2.1216478189072 0.0129960281971711 no 3298 0.0169336617930682 4698 9561992
SGTC_2267 7931562 200 µM -2.13476083288791 0.0125463543117223 no 3299 0.0163902755525733 4683 934880
SGTC_837 0091-0265 12.5 µM -2.13697450591657 0.0124717867984792 no 3300 0.0163000326220219 4720 759367
SGTC_658 3253-0951 102 µM -2.14650042220555 0.0121552690644477 no 3301 0.0159165375616446 4720 1184878
SGTC_1929 genistein trimethyl ether 50.5 µM -2.15363093724144 0.0119229221920803 no 3302 0.0156345630524439 4683 136420
SGTC_1878 temozolomide 1 mM -2.15927994013463 0.0117415946082109 no 3303 0.0154142277208708 4692 5394 DNA alkylating agent.
SGTC_3136 9095672 49.47 µM -2.16684746378282 0.0115024380121394 no 3304 0.0151232434768374 4629 17217380
SGTC_3128 9127691 49.47 µM -2.16985854651988 0.0114084619288857 no 3305 0.0150087817510946 4710 41316314
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -2.17017148908414 0.0113987333453269 no 3306 0.0149969285428827 4688 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2176 5809774 33.9695 µM -2.17336022549145 0.0113000138917777 no 3307 0.0148766079751528 4673 2870539
SGTC_2460 5552655 174.22 µM -2.17579985333579 0.0112249884711695 no 3308 0.0147851148347277 4694 5401989
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -2.17641957265975 0.0112059994690978 no 3309 0.0147619507858991 4712 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2194 5927483 104.545 µM -2.17935329369539 0.0111164850115413 no 3310 0.0146527164958403 4741 760979
SGTC_2880 9042983 58.44 µM -2.19445606878461 0.0106654392917696 no 3311 0.0141013194398897 4672 6464714
SGTC_929 2805-0021 398 µM -2.19457598727687 0.0106619226538904 no 3312 0.0140970138099644 4721 3098024
SGTC_2816 7982706 58.44 µM -2.19768845856977 0.0105710012835697 no 3313 0.0139856572887268 4689 2981853
SGTC_2841 9004761 38.96 µM -2.2090371418938 0.0102451813775471 no 3314 0.0135860287958991 4664 2991039
SGTC_453 enantio-paf c16 10 µM -2.21813952822639 0.00999021644296991 no 3315 0.0132726601862617 4278 13871343 A lipid and platelet activating factor
SGTC_402 epigallocatechin gallate 10 µM -2.22093485513503 0.00991303692967162 no 3316 0.0131776870179206 4712 65064 An antioxidant.
SGTC_339 3091-4833 71.4 µM -2.27737667136562 0.00846228763632147 no 3317 0.0113818709845165 4563 3240077
SGTC_2910 7948405 25.97 µM -2.35214317618314 0.00682918003527665 no 3318 0.00933279436265673 4743 2971328
SGTC_1602 st001878 87.6 µM -2.35373005319068 0.0067977672453865 no 3319 0.00929305151848945 4722 595405 YLR310C CDC25
SGTC_812 4251-0442 148 µM -2.35820562444481 0.00670985837862532 no 3320 0.00918175896923723 4751 5723007
SGTC_398 bronopol 33.3 µM -2.39455848114331 0.0060322564775533 no 3321 0.00832019477736156 4714 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1912 st060209 90.8 µM -2.39604522931452 0.00600588356038348 no 3322 0.0082865225631616 4722 688787
SGTC_765 1319-0117 244 µM -2.459475883781 0.00497174596552932 no 3323 0.00695700226961168 4748 3487746 YGL099W LSG1
SGTC_1553 gossypol 38.6 µM -2.46829518375203 0.00484129475079539 no 3324 0.00678791588839253 4754 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_571 k831-0106 44.2 µM -2.48428878977182 0.00461248791889792 no 3325 0.00649052438648648 4716 4783639
SGTC_2001 4023502 57.655 µM -2.487625049134 0.00456599359197505 no 3326 0.00642996173000966 4745 108941 YCR052W RSC6
SGTC_394 menadione 8.33 µM -2.48879020206591 0.0045498547855732 no 3327 0.00640892897897787 4751 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_943 3253-1379 105 µM -2.51982114991056 0.00413835757392754 no 3328 0.00587072383631616 4745 668464
SGTC_533 1222-0222 6.71 µM -2.54156375308765 0.00387020853443835 no 3329 0.00551789090304937 4773 3982874
SGTC_3008 9078912 71.4286 µM -2.54714506981492 0.00380393560738366 no 3330 0.00543041364197869 4766 16648731
SGTC_3228 9131799 49.47 µM -2.55509102834609 0.0037113397545019 no 3331 0.00530800156604195 4780 17015818
SGTC_1295 1013-0063 9.78 µM -2.60068782422232 0.00321802245788225 no 3332 0.00465185367819847 4785 6826038
SGTC_403 arphamenine a 50 µM -2.61980588072228 0.00302935694144273 no 3333 0.0043989915948263 4779 5487158 An arginine aminopeptidase inhibitor.
SGTC_338 4055-0136 114 µM -2.63133660468984 0.0029204421754379 no 3334 0.00425248765188562 4767 2900563
SGTC_934 2950-0684 338 µM -2.78536444268114 0.00176807172114987 no 3335 0.00267337955051648 4783 1121253
SGTC_73 0327-0325 16.231 µM -2.79047537058661 0.00173816546904078 no 3336 0.0026315352169983 4677 53298
SGTC_1855 st056195 39.6 µM -2.80802206048966 0.00163896226131322 no 3337 0.00249234060039608 4755 4028379
SGTC_3061 glucosamine 200 µM -2.80870105865042 0.00163522920208202 no 3338 0.00248709057615855 4743 91431 and experimental redox chemotherapeutic
SGTC_1923 st058458 19.1 µM -2.94519201876688 0.00102427932913563 no 3339 0.00161377145328641 4783 3534982
SGTC_3000 9075062 71.4286 µM -3.0440490747748 0.000721407391816256 yes 3340 0.00116708530372126 4792 17057871
SGTC_567 1080-0542 68.4 µM -3.20020110222402 0.000406400829741511 yes 3341 0.000686658646714479 4772 5950415
SGTC_936 3005-4620 401 µM -3.20439757108243 0.000400044670214092 yes 3342 0.000676727197212078 4789 777207
SGTC_2516 gossypol 71.55 µM -3.20927945545125 0.000392766485487875 yes 3343 0.000665340444620995 4793 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2520 obtusaquinone 4.71 µM -3.33240289975838 0.00024521136679762 yes 3344 0.000430497548720319 4796 5967872
SGTC_2836 9010338 19.48 µM -3.45409279650817 0.00015161020243425 yes 3345 0.000276073675382933 4777 2994051
SGTC_536 3852-0578 10.6 µM -3.68209895896911 5.91220744859934e-05 yes 3346 0.000115660790116039 4800 2869208
SGTC_335 4077-0256 27.6 µM -4.19453431073591 5.85689720082829e-06 yes 3347 1.36716381222173e-05 4780 3121989