SGTCid condition conc unit MPE1|YKL059C.score MPE1|YKL059C.strain.pval MPE1|YKL059C.strain.significant MPE1|YKL059C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_326 k292-0812 17.5 µM 6.62236617198424 2.77120129605324e-12 yes 1 1.76747027719296e-11 1 3579357 SGTC_323 4013-0906 34.3 µM 6.29238065815535 2.95070256033093e-11 yes 2 1.56316835198135e-10 1 2910086 SGTC_1968 st069590 43.6 µM 4.84858059864908 2.35323054525876e-07 yes 3 6.21740036684882e-07 11 6384066 SGTC_2970 9090938 41.86 µM 4.50096440843233 1.4714749051894e-06 yes 4 3.38229167305854e-06 8 17217104 SGTC_3308 9128332 17.569 µM 4.47840426551048 1.65009551647313e-06 yes 5 3.76015413870151e-06 7 17332805 YDL196W YDL196W SGTC_130 0136-0219 337.655 µM 4.44916299542432 1.91273470485001e-06 yes 6 4.31027889493317e-06 6 234244 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 4.38050830753403 2.69604495398867e-06 yes 7 5.92013889969983e-06 2 1241132 A phosphatase inhibitor. SGTC_325 2810-4341 181 µM 4.32429679378282 3.55779728788182e-06 yes 8 7.65095879312614e-06 3 774970 SGTC_10 0279-0212 42.575 µM 4.29216292783828 4.16287446886968e-06 yes 9 8.84705172794678e-06 6 39851 YBR002C RER2 SGTC_382 3229-0966 23.2 µM 4.1369434419317 8.7552683552256e-06 yes 10 1.75981408894406e-05 4 5722370 SGTC_2025 5147754 141 µM 3.85965902666572 3.10343860863329e-05 yes 11 5.67726731700721e-05 7 315777 YLR208W SEC13 SGTC_2946 9065502 71.43 µM 3.79832074173127 4.06177117351878e-05 yes 12 7.28398655160134e-05 2 16489101 SGTC_328 k915-0120 63.5 µM 3.71926000411491 5.71282614156075e-05 yes 13 9.99036472723323e-05 4 6624543 SGTC_863 0466-0191 129 µM 3.70367972140895 6.10536054839647e-05 yes 14 0.000106247256382563 21 765160 YPR165W RHO1 SGTC_1649 st011737 51.3 µM 3.64863278862105 7.70553374414958e-05 yes 15 0.000131819812030499 3 1761035 SGTC_196 k015-0023 18.111 µM 3.46208335508128 0.00016567785724155 yes 16 0.000268005559403027 3 5211998 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 3.45363608333015 0.000171375776335358 yes 17 0.000276541588499699 19 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_439 amiodarone 34.4 µM 3.40036191708213 0.000211751572991879 yes 18 0.000336483578789742 10 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1983 st071813 46.9 µM 3.39506358978752 0.000216219455681494 yes 19 0.000343063312453389 9 11838595 SGTC_2362 9071156 126 µM 3.30764049817994 0.000303884680217059 yes 20 0.000470427519416978 9 653133 SGTC_1805 st050013 60.3 µM 3.28967141046376 0.000325587716984123 yes 21 0.000501522209180372 4 4037144 SGTC_327 1273-0057 3.96 µM 3.25290993256368 0.000374550643052832 yes 22 0.000571148489593622 13 3108138 SGTC_1205 4161-2785 76 µM 3.20544030744856 0.000447904259486252 yes 23 0.000674280074719997 7 3498106 SGTC_33 0986-0033 35.816 µM 3.17831631173567 0.000495584927029482 yes 24 0.000740665238306532 6 2848082 SGTC_3096 9117468 49.47 µM 3.14789116575632 0.0005546368405119 yes 25 0.000822264551535874 2 41316311 SGTC_2036 5160441 105 µM 3.12384528493951 0.000605839406334494 yes 26 0.000892521449310489 36 134534 YIL048W NEO1 SGTC_54 0159-0055 9 µM 3.10931197871814 0.000638867899397321 yes 27 0.000937617976309034 14 3319099 SGTC_807 1315-0151 48 µM 3.10364044847948 0.000652202032917154 yes 28 0.000955777407872417 24 4011080 SGTC_798 1287-0182 476 µM 3.05671705059461 0.000772782543081653 yes 29 0.00111887700972363 11 1649755 SGTC_1201 1889-3372 45.9 µM 2.9945104839842 0.000964330217274816 yes 30 0.00137442804421715 15 5392199 SGTC_1136 pergolide 1.05886 µM 2.9157557504462 0.0012691825434282 no 31 0.00177414080437715 37 47811 A dopamine receptor agonist. SGTC_2363 9053361 176 µM 2.90319428757916 0.00132525450612826 no 32 0.0018468870287453 28 6469797 YMR079W SEC14 SGTC_2027 5150920 200 µM 2.90215076236699 0.001330012993466 no 33 0.00185305067050417 7 786715 SGTC_1343 1487-0095 224 µM 2.89685717551907 0.00135439322759506 no 34 0.0018846065466534 11 4560101 YGL055W OLE1 SGTC_2371 9071574 200 µM 2.87523241173175 0.00145828829341272 no 35 0.00201865098842142 10 45596039 SGTC_415 dibenzyl ketone 100 µM 2.85567617537289 0.00155845529085814 no 36 0.00214726448082939 13 7593 SGTC_1854 st056233 32.9 µM 2.8552868120625 0.0015605118104521 no 37 0.0021498989642017 13 5393174 SGTC_1315 1237-0019 3.69 µM 2.85256142095486 0.00157497605228306 no 38 0.00216842152458324 19 825140 SGTC_1809 st050081 57.6 µM 2.84559307748271 0.00161251596428637 no 39 0.00221644010801045 12 5036894 SGTC_2605 digitonin 300 nM 2.82221344291398 0.00174450083540216 no 40 0.00238467116118966 17 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2545 solidagenone 89.61 µM 2.81811682776088 0.00176861487236801 no 41 0.00241531148683714 2 6708572 An anti ulcer agent SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 2.81080850326544 0.00181238844190184 no 42 0.00247085941070209 41 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3246 9135460 32.98 µM 2.80077273458206 0.00187410400008356 no 43 0.00254902040014534 9 41446951 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.79839674239386 0.00188899219369676 no 44 0.00256784936021565 22 688662 SGTC_2861 9024595 19.48 µM 2.7673240839877 0.00209384031074061 no 45 0.00282592695116143 3 16482810 SGTC_742 0kpi-0133 140 µM 2.73568531386902 0.00232293289101656 no 46 0.00311252622806287 17 2728852 SGTC_1923 st058458 19.1 µM 2.73474291130629 0.00233009214675923 no 47 0.0031214506907082 32 3534982 SGTC_2257 7960413 200 µM 2.72024101807404 0.00244280830553368 no 48 0.00326171746910876 39 2974689 YIL048W NEO1 SGTC_2831 7999036 19.48 µM 2.71938275780284 0.00244963123603688 no 49 0.00327019382569932 25 2988270 SGTC_902 1120-0002 2.07 µM 2.71735140296954 0.002465848676488 no 50 0.00329033489599149 32 3280475 SGTC_1647 st011722 22.4 µM 2.71259191059245 0.00250422732010699 no 51 0.00333796324873205 23 2854783 SGTC_2874 9043904 71.43 µM 2.71030387468601 0.00252286866673417 no 52 0.00336107952710555 15 4463428 SGTC_561 1550-0330 72.9 µM 2.6727397676768 0.00284738897972648 no 53 0.00376172941801064 17 6812934 SGTC_435 c-PAF 6.7 µM 2.66835876855518 0.00288759091488908 no 54 0.00381114084737587 29 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3095 9117207 49.47 µM 2.64380037621165 0.00312257339317369 no 55 0.00409904948124918 8 17015229 SGTC_1989 st071868 50.2 µM 2.64056257655446 0.00315480539237787 no 56 0.00413842529888332 16 16414057 SGTC_2192 5915882 198.485 µM 2.61141490534464 0.00345872758818302 no 57 0.00450842123497101 46 2876149 SGTC_1903 st060211 78.3 µM 2.58346524137329 0.00377459877481355 no 58 0.00489066613072259 17 688960 SGTC_2808 7946468 45.46 µM 2.57748614704514 0.00384543964403701 no 59 0.00497609352941574 32 2970879 SGTC_270 tamoxifen 5.46 µM 2.57314947128682 0.00389756410868039 no 60 0.00503888368798447 28 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_425 3825-7017 13.1 µM 2.54597111498695 0.0042388930326385 no 61 0.00544871026018683 31 3397440 SGTC_2918 7977171 22.06 µM 2.54256066421474 0.0042835598513466 no 62 0.00550217484206152 20 2236483 SGTC_109 0132-0036 33.701 µM 2.52759436692856 0.00448458883547313 no 63 0.00574234777347232 19 67274 A color developer. SGTC_1261 0712-0010 12.7 µM 2.52640816141419 0.00450087680530303 no 64 0.00576177564936021 34 2840123 SGTC_1712 st032288 53.4 µM 2.51636972002799 0.00464084510507688 no 65 0.00592853637536808 69 2883011 SGTC_1658 st012944 20 µM 2.51276514304209 0.00469204443077759 no 66 0.00598945258861006 34 24207260 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 2.49009972451219 0.00502568661357856 no 67 0.00638536282497001 9 4000243 SGTC_1293 1000-1278 195 µM 2.48410357499426 0.00511741428635721 no 68 0.00649390130040089 29 678847 SGTC_38 0929-0051 58.268 µM 2.45947537272373 0.00550999391695288 no 69 0.00695701217454484 31 1379719 SGTC_211 3455-0679 143.504 µM 2.44510676716104 0.00575119394228115 no 70 0.00724046332125648 21 748649 SGTC_2114 5491910 81.25 µM 2.439673796502 0.00584480842037487 no 71 0.00735026477568094 30 2849228 SGTC_1332 1480-0653 17.5 µM 2.43890730611044 0.00585812390374597 no 72 0.00736587325876483 21 5749438 SGTC_1271 0832-2808 169 µM 2.43039599479084 0.00600780086551048 no 73 0.00754116703922595 45 3663794 SGTC_426 0988-0037 14.6 µM 2.42648563585657 0.00607769649126292 no 74 0.00762292691753213 42 5383008 SGTC_1997 st073024 93.8 µM 2.40977667166668 0.00638454485132384 no 75 0.00798114406078823 23 686268 SGTC_2447 5741742 33.78 µM 2.40054643431923 0.00655986472153889 no 76 0.00818530680593368 44 1776504 SGTC_1273 0849-0096 14.1 µM 2.38800695920754 0.00680485584458103 no 77 0.00847001050243399 31 5286025 SGTC_2021 4019055 173 µM 2.37393651820899 0.00708935071332311 no 78 0.00879978802849686 75 44827708 YER133W GLC7 SGTC_1017 4239-0030 168 µM 2.36885898018901 0.00719456306085877 no 79 0.00892152765710909 23 1149593 SGTC_2078 5212016 200 µM 2.35884419655912 0.0074061247711671 no 80 0.00916597529262789 20 1899708 SGTC_588 3970-1144 52.9 µM 2.35218766491858 0.00754975884079585 no 81 0.00933167813324914 8 1888707 SGTC_2557 derrustone 83.84 µM 2.34568964853205 0.00769233320970767 no 82 0.00949595697622985 30 629853 An antioxidant. SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.33131985917624 0.00801606695965052 no 83 0.00986824990652532 26 5282309 SGTC_784 4579-0127 173 µM 2.32296322620265 0.00820978905983962 no 84 0.0100905640196029 27 1948547 SGTC_199 4063-0024 41.6 µM 2.32065568141983 0.00826400167555986 no 85 0.0101527172158604 9 306215 SGTC_135 0933-0004 26.348 µM 2.31504895837862 0.00839703600664221 no 86 0.0103051264457678 39 21230617 YGL099W LSG1 SGTC_1521 st012942 49.4 µM 2.29434072218734 0.00890482699860829 no 87 0.0108854676036905 33 24207259 SGTC_24 0417-1663 219 µM 2.28952837717868 0.00902661467416453 no 88 0.0110243355357953 24 4329390 SGTC_769 0302-0231 76 µM 2.28687155345528 0.00909447488410661 no 89 0.0111016607254539 67 571869 YER009W NTF2 SGTC_655 k060-0012 42 µM 2.28550045625122 0.00912966968721834 no 90 0.0111417498524627 50 5994525 SGTC_2640 pentamidine 10.38 µM 2.27389618047184 0.00943234698568862 no 91 0.0114861147055151 53 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1151 3909-8316 15.3 µM 2.25670761937909 0.00989680164940357 no 92 0.0120131752179949 35 800431 SGTC_3224 9130643 49.47 µM 2.2512073431048 0.010049584339322 no 93 0.0121862040168878 42 17644395 SGTC_2543 pimpinellin 60.67 µM 2.24715559671473 0.0101634436017604 no 94 0.0123150424129633 31 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2929 9013348 24.6 µM 2.23205790534931 0.010597675310913 no 95 0.0128055680418926 28 2995952 SGTC_595 3909-8003 73.7 µM 2.2271501390037 0.010742268446967 no 96 0.0129686206017887 43 699517 SGTC_1226 3909-7979 35.4 µM 2.20857472298798 0.0113052046602976 no 97 0.013602117555723 52 6615510 SGTC_1115 galangin 695.678 nM 2.19593288660472 0.0117028278820951 no 98 0.0140483737141207 29 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2894 9048625 32.47 µM 2.19437201968486 0.0117527539055979 no 99 0.0141043378677449 50 4092861 SGTC_1606 st000094 49.2 µM 2.19173684726219 0.0118374622757809 no 100 0.0141992567436853 48 1242210 SGTC_321 4534-3890 65.3 µM 2.18122738486019 0.0121805822802443 no 101 0.0145833011376136 38 699746 SGTC_398 bronopol 33.3 µM 2.16872454161632 0.0125999819506039 no 102 0.0150518015122631 55 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3162 9099653 49.47 µM 2.15543425340352 0.0130594450644233 no 103 0.0155639341693862 21 25237511 SGTC_809 3998-0021 90 µM 2.15475688801696 0.0130832454550157 no 104 0.0155904317629142 55 715485 SGTC_1263 0774-1208 64.8 µM 2.15304718818091 0.0131434854819099 no 105 0.0156574850756057 52 906585 SGTC_2967 9089538 49.85 µM 2.14477314578057 0.0134384138030798 no 106 0.0159854946522933 54 728216 SGTC_32 0928-0142 34.1 µM 2.13542053640502 0.0137786510715925 no 107 0.0163633373369632 43 2244242 SGTC_797 k781-0471 270 µM 2.13197861526416 0.0139057214342827 no 108 0.0165043022965827 52 23738129 SGTC_133 0724-0033 378.92 µM 2.12474432772034 0.0141760972017969 no 109 0.0168039762459497 40 280309 SGTC_3303 9125618 40.5795 µM 2.11458463498556 0.0145634476055045 no 110 0.0172326821778953 44 22695467 SGTC_1597 7-benzyloxygramine 47.5 µM 2.10443974897054 0.0149592877833246 no 111 0.0176700525781701 99 260807 SGTC_2717 st081029 62.2815 µM 2.09582766773412 0.0153025441832776 no 112 0.0180487405230077 26 5292846 SGTC_2107 5363541 170.161 µM 2.08716277208677 0.0156547105902436 no 113 0.0184367117014509 49 244052 SGTC_2814 7977482 42.97 µM 2.08623507434909 0.0156928237940994 no 114 0.0184786672779041 60 6456762 SGTC_234 nsc-17383 10.7 µM 2.08247329839687 0.0158481881928085 no 115 0.0186496296873047 48 408974 SGTC_1010 4112-3296 15.2 µM 2.07761612221209 0.0160507430875379 no 116 0.0188723650281985 41 704384 SGTC_3176 9106582 49.47 µM 2.07092097464725 0.0163335797217405 no 117 0.0191830908521948 16 17018027 SGTC_313 3474-0040 5.03 µM 2.07085301068132 0.0163364726056026 no 118 0.019186267265444 60 1043375 YIL048W NEO1 SGTC_1270 0831-1170 17.3 µM 2.07067966874266 0.0163438528860282 no 119 0.0191943707245595 48 6764716 SGTC_1340 1486-1359 257 µM 2.05120368553093 0.0171914570841152 no 120 0.0201235575735755 46 4309068 SGTC_334 1502-1024 68.5 µM 2.03876941934965 0.0177520213568892 no 121 0.0207365228613126 36 3296216 SGTC_1667 st014849 34.6 µM 2.03704113787755 0.0178311572316857 no 122 0.0208229598524162 41 5348460 SGTC_2443 5493264 126.67 µM 2.03553926047052 0.0179001705257349 no 123 0.0208983211677457 38 5340055 SGTC_1793 st048256 72.231 µM 2.03288820244074 0.018022546219023 no 124 0.0210319096075473 39 672022 SGTC_780 0109-0199 192 µM 2.0251537114412 0.018383662539149 no 125 0.0214257915280185 56 610414 SGTC_2048 5246248 200 µM 2.01777784570144 0.0187337581297437 no 126 0.0218072015915789 40 677046 SGTC_333 3486-0131 40.1 µM 2.01222229149676 0.0190011845674731 no 127 0.0220982548380358 46 6744690 SGTC_394 menadione 8.33 µM 2.00017490448009 0.0195922773262996 no 128 0.022740690337776 55 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_738 1315-0003 72.4 µM 1.98671415317205 0.0202711139003676 no 129 0.0234770412533119 45 6251474 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.98483204093036 0.0203676010286773 no 130 0.0235815806981428 39 17037758 SGTC_1367 1812-0510 76.9 µM 1.98331100631075 0.0204458615313821 no 131 0.0236663503752473 50 1142582 YDR527W RBA50 SGTC_2771 fluoxetine 41.05 µM 1.9825067503758 0.0204873451202349 no 132 0.0237112763118898 39 3386 A selective serotonin reuptake inhibitor. SGTC_1610 st001799 48.1 µM 1.98163895315261 0.0205321861438578 no 133 0.0237598320917536 36 621897 SGTC_2491 paeonol 100 µM 1.97501041322281 0.0208774485260126 no 134 0.0241334831498756 34 11092 Increases levels of cortical cytochrome oxidase. SGTC_2080 5212524 12.4 µM 1.97157644098373 0.0210582389696499 no 135 0.0243289894043759 57 260183 SGTC_1342 1486-1464 234 µM 1.96214302950533 0.0215617164050607 no 136 0.0248729172344331 55 3253938 SGTC_1140 3229-1848 2.98 µM 1.9602029888063 0.0216665112882127 no 137 0.0249860346503265 39 2849525 SGTC_2879 9041815 71.43 µM 1.95936187871958 0.0217120789557228 no 138 0.025035210886779 27 4942971 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.95870606888997 0.0217476640143802 no 139 0.0250736096524623 27 6708630 An antioxidant. SGTC_865 0488-0499 301 µM 1.95606308314983 0.0218915754842094 no 140 0.0252288616552166 48 9634651 SGTC_1135 dihydrocapsaicin 536.708 nM 1.95318855151989 0.0220490068244804 no 141 0.0253986285728668 46 107982 A Capsaicinoid. SGTC_1510 1123-0200 71.5 µM 1.95114354117789 0.0221615881279878 no 142 0.0255199864625547 76 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1207 2099-0101 141 µM 1.94764484911674 0.0223553219800563 no 143 0.0257287367022028 52 5837381 SGTC_2346 9031566 143.75 µM 1.94493397511905 0.0225064123424489 no 144 0.0258914626449414 55 4771086 SGTC_869 0564-0080 44.1 µM 1.9417590665296 0.0226844595126965 no 145 0.0260831371990512 39 6843321 SGTC_72 0744-0168 198.391 µM 1.94073879927132 0.0227419270118079 no 146 0.0261449838387185 53 677577 SGTC_749 1000-0129 128 µM 1.93716444074122 0.0229442248250269 no 147 0.0263626227350033 50 708470 SGTC_1778 st046819 58.9 µM 1.92155557327254 0.0238454888601301 no 148 0.0273308516521567 73 671715 SGTC_2641 levomentholum 100 µM 1.91642085363663 0.0241484000316936 no 149 0.0276557742697322 38 16666 SGTC_3235 9132602 49.47 µM 1.90235458694952 0.0249948053684861 no 150 0.0285624068926911 62 4912240 SGTC_1977 st070720 65.3 µM 1.89507624107183 0.0254424394413314 no 151 0.0290411508918518 33 682188 SGTC_1818 st052136 56.3 µM 1.89166975640238 0.0256542411448377 no 152 0.0292674976632992 83 674169 SGTC_2366 9070441 60.58 µM 1.88973737331276 0.0257750438334406 no 153 0.0293965465325449 56 6837235 SGTC_1886 st057356 49.9 µM 1.8866939634793 0.0259662673603585 no 154 0.0296007500381749 54 24207747 SGTC_3186 9110464 49.47 µM 1.88309755480291 0.0261937653482329 no 155 0.0298435742729135 41 17018021 SGTC_1118 chelidonine 707.474 nM 1.87951986191373 0.0264217306241551 no 156 0.0300867720525586 38 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1019 4262-0212 3.4 µM 1.87729689545807 0.0265642081542145 no 157 0.0302387067479607 73 4677213 SGTC_2032 5185112 25.99 µM 1.87464801691327 0.0267348214089839 no 158 0.0304205813616552 40 5718189 SGTC_2777 climbazole 1.536 µM 1.86917785231735 0.0270900498201834 no 159 0.0307990372629764 67 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2707 st078556 66.6 µM 1.86508870010809 0.0273581616009506 no 160 0.0310844860996921 46 17250899 SGTC_1426 4048-4480 71.7 µM 1.86065001965893 0.0276516919036359 no 161 0.0313968081237113 49 14224343 SGTC_3327 9140648 26.9345 µM 1.85739503750365 0.0278686083925128 no 162 0.0316274859954073 103 8029710 SGTC_1837 st055472 66.5 µM 1.85288919106813 0.0281712219090662 no 163 0.0319491213422238 48 676091 SGTC_1398 3558-0053 112 µM 1.84991764956145 0.0283722843140789 no 164 0.032162709821697 35 4532369 SGTC_610 4215-0184 155 µM 1.84888037741796 0.0284427494814448 no 165 0.0322375438591016 74 5605015 SGTC_1666 st014829 29 µM 1.83728479280077 0.0292404324222499 no 166 0.0330839318357831 54 3858230 SGTC_2435 5706476 10.6 µM 1.82690085331204 0.0299704509209889 no 167 0.0338573389746274 51 5725375 SGTC_2948 9070189 9.45 µM 1.82600874386658 0.0300338675113475 no 168 0.033924472382395 51 6473636 YDL196W YDL196W SGTC_602 3130-1533 38.1 µM 1.81107635622545 0.0311119740162465 no 169 0.0350645164516289 80 720941 SGTC_2122 5258151 111.688 µM 1.8094333368086 0.0312325299857628 no 170 0.0351918539913866 71 2173356 SGTC_230 MPP+ 141.667 µM 1.7962773143591 0.0322118464502625 no 171 0.0362252119642236 69 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2973 9094665 17.96 µM 1.79607739699379 0.0322269213226238 no 172 0.036241104332823 94 25237061 YIL048W NEO1 SGTC_1800 st050079 29.0735 µM 1.79261700535823 0.0324887779406767 no 173 0.0365170926915187 96 3645560 SGTC_2434 5670830 169.91 µM 1.79163537921258 0.0325633788474316 no 174 0.0365956960116854 68 1549830 SGTC_2551 apiole 73.87 µM 1.78432965024787 0.0331230440634342 no 175 0.0371850574984056 43 10659 A possible DNA adduct former. SGTC_1851 st056236 18.9 µM 1.78279016635063 0.0332419835398981 no 176 0.0373102335571766 65 5393171 SGTC_1117 retinoic acid 1.10837 µM 1.78089094221865 0.033389200760099 no 177 0.037465134315565 53 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.77856444617541 0.0335702688652197 no 178 0.0376555986951743 67 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_835 0312-0010 67.2 µM 1.77831001678656 0.0335901197028932 no 179 0.0376764760553461 77 1626196 SGTC_1718 roemerine 11.9335 µM 1.77556360487716 0.0338050131670674 no 180 0.0379024366238765 84 235224 An aporphine alkaloid with mutagenic activity. SGTC_2935 9038016 29.96 µM 1.77221754526541 0.0340683532842534 no 181 0.0381792261210489 65 6463195 SGTC_3153 9100258 49.47 µM 1.76498634531277 0.0346432237271617 no 182 0.0387830303085965 64 25236848 SGTC_35 0133-0054 64.071 µM 1.75732913777631 0.0352606216269416 no 183 0.0394308620153569 88 99677 SGTC_3084 9116877 49.47 µM 1.75613529423871 0.0353576892161541 no 184 0.0395326549600485 47 27241325 SGTC_808 0711-0032 135 µM 1.75336265807205 0.0355839690319194 no 185 0.0397698882444664 85 4252555 SGTC_3314 9135860 59.4275 µM 1.74859629332061 0.0359757342698054 no 186 0.0401804137447196 52 25252478 SGTC_722 3534-0461 190 µM 1.74844197332282 0.0359884772139723 no 187 0.0401937625947797 53 658262 SGTC_1950 st077106 7.18 µM 1.74719809381894 0.0360913253797804 no 188 0.0403014911376613 69 13831864 SGTC_462 ag-879 158 µM 1.7462318812677 0.0361713810955175 no 189 0.0403853335308664 90 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1600 coumarin 106 71.1 µM 1.74604861269852 0.0361865822384993 no 190 0.0404012524973145 64 100336 A hepatotoxic, DNA x-linker. SGTC_3310 9130229 44.1445 µM 1.7423813110613 0.0364918663126733 no 191 0.0407208719623911 64 7761258 SGTC_2555 cholic acid 100 µM 1.74108560021829 0.0366002301484893 no 192 0.0408342875264262 53 6708657 Influences liver metabolism. SGTC_1194 1488-0194 225 µM 1.74107520739325 0.0366011003918973 no 193 0.0408351982613917 56 1391452 SGTC_3086 9117350 49.47 µM 1.73618100796932 0.0370128011906596 no 194 0.0412659171424157 30 2679265 SGTC_3098 9119039 49.47 µM 1.73389548213036 0.0372063524935123 no 195 0.0414683148177355 73 17161528 SGTC_2288 7946289 167.31 µM 1.73214449329294 0.0373551950111627 no 196 0.0416239194748144 62 1246052 SGTC_3252 9135871 49.47 µM 1.7238806623017 0.0380642386296246 no 197 0.0423646944802409 70 17682838 SGTC_1980 st071811 45.7 µM 1.72158177784953 0.0382634249534968 no 198 0.0425726532286876 78 4974850 SGTC_359 0081-0058 15.9 µM 1.72092850871122 0.0383201821269745 no 199 0.042631898802202 85 3494159 SGTC_1277 0873-0036 22 µM 1.72047485271733 0.0383596369282936 no 200 0.0426730804837445 61 5965735 SGTC_1999 st074831 12.5 µM 1.70433144319981 0.0397853368667694 no 201 0.0441595919326803 87 17112523 SGTC_25 0118-0223 35.662 µM 1.70297222186764 0.0399073168462445 no 202 0.0442866334695402 55 5333628 SGTC_1500 4488-1866 171 µM 1.69980039533122 0.0401931471176336 no 203 0.0445842385787575 66 2900003 SGTC_763 3453-1109 128 µM 1.69946844874832 0.0402231564887296 no 204 0.0446154772550621 56 1560353 SGTC_608 k048-0125 159 µM 1.6947903150509 0.0406480182875619 no 205 0.0450576026932677 68 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2770 toltrazuril 17.5 µM 1.69143811625552 0.0409546948468274 no 206 0.0453765788108612 59 68591 Kills coccidiodes. SGTC_1289 0976-0073 69.1 µM 1.6834128056824 0.0416965203812208 no 207 0.0461476029864288 74 3391136 SGTC_2866 9034245 58.44 µM 1.67846212491698 0.042159542715686 no 208 0.0466284592150491 54 6462273 SGTC_2320 7373003 200 µM 1.67736914455695 0.0422623245581381 no 209 0.0467351595862965 79 5415828 SGTC_948 3448-0295 75.3 µM 1.67404159035606 0.0425764902894321 no 210 0.047061212897917 75 678569 SGTC_1200 1643-0193 18.4 µM 1.66913698911769 0.0430429906697046 no 211 0.0475451171012206 84 5403974 SGTC_2744 captopril 92.04 µM 1.6629891223423 0.0436335668313426 no 212 0.0481573064605635 27 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3193 9111931 49.47 µM 1.66148588374288 0.0437789613621908 no 213 0.0483079508466803 73 17087244 SGTC_3090 9117696 49.47 µM 1.65804615872927 0.0441131251106748 no 214 0.0486540749941931 64 7923821 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.65507783464533 0.0444031432938216 no 215 0.0489543552046958 68 6710655 SGTC_3341 9147222 25.867 µM 1.65461781725667 0.0444482261898798 no 216 0.049001023503551 76 1939759 SGTC_887 0885-0007 9.62 µM 1.64659312089377 0.0452406166156329 no 217 0.0498208526802708 95 5719458 SGTC_1861 st057647 17.4 µM 1.64591470746804 0.0453081235933033 no 218 0.0498906602462619 73 688668 SGTC_1631 benzylvanillin 81.9 µM 1.64369112192674 0.045529954443062 no 219 0.0501200103755369 84 75506 SGTC_1742 st038235 28.8875 µM 1.6369197076826 0.0462108722020587 no 220 0.05082362374384 90 564103 YBR002C RER2 SGTC_3230 9131665 49.47 µM 1.62653116065073 0.0472713928083411 no 221 0.0519183550480116 43 15943720 SGTC_2638 epoxomicin 18 µM 1.62310754465787 0.0476251376657975 no 222 0.0522832085405622 66 9915668 A protesome inhibitor. SGTC_2906 7926292 26.41 µM 1.61786825532723 0.0481705885347338 no 223 0.0528454964166067 66 2966319 SGTC_1432 4049-0298 68.4 µM 1.61026485058778 0.0489710401531591 no 224 0.0536700246073607 68 741646 SGTC_147 4466-0538 29.23 µM 1.60491640998578 0.0495404397833997 no 225 0.0542561008330214 88 6742687 YHR072W ERG7 SGTC_3202 9113761 49.47 µM 1.60450441386531 0.0495845195308391 no 226 0.0543014561611097 100 4798415 SGTC_994 3910-0338 138 µM 1.60061937684737 0.0500017231410372 no 227 0.0547306239376549 102 3479481 SGTC_2563 tomatine 8.54 µM 1.59874569272988 0.0502039311316713 no 228 0.0549385601740286 89 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_279 1273-0055 2.93 µM 1.59417543121383 0.0506998882220798 no 229 0.0554483738707458 90 2847562 SGTC_1871 st057448 67.3 µM 1.59043529844941 0.0511086576485615 no 230 0.0558683595285405 87 691747 SGTC_2262 9014885 67.46 µM 1.58501360758217 0.0517058608950818 no 231 0.0564816212974964 53 6457424 SGTC_635 k038-0028 24.7 µM 1.58378264523924 0.0518422220305384 no 232 0.0566215949748108 113 4035102 SGTC_2094 5332512 191.667 µM 1.5826534781098 0.051967557874983 no 233 0.05675023363855 82 755774 SGTC_646 4092-0839 27.3 µM 1.57905330481721 0.0523687798166262 no 234 0.0571619154768362 100 877796 SGTC_3107 9121808 49.47 µM 1.57199869183937 0.0531621111601778 no 235 0.0579754272995825 62 662681 SGTC_1360 1598-0022 39.8 µM 1.57137056299997 0.0532332073040776 no 236 0.0580482997392348 107 761525 SGTC_1558 st069300 45.6 µM 1.56750190766667 0.0536727526248533 no 237 0.0584987103330134 87 24208000 SGTC_1995 st072814 61.1 µM 1.56654499112592 0.0537819169568874 no 238 0.0586105421887596 72 5769371 SGTC_1783 st039459 87.517 µM 1.56537673288903 0.0539154292770994 no 239 0.0587473003433483 94 729761 SGTC_3168 9103419 49.47 µM 1.56257446515141 0.0542367511534596 no 240 0.0590763591167675 58 16649256 SGTC_2324 6149169 200 µM 1.56225516534523 0.0542734596116464 no 241 0.0591139447520923 85 2888231 SGTC_39 0986-0283 58.349 µM 1.55898518552156 0.0546505269327821 no 242 0.0594999432716547 85 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3069 9117009 49.47 µM 1.55362607255924 0.055272971733922 no 243 0.0601368182126532 66 41904981 SGTC_2650 prasterone 100 µM 1.54914782483827 0.0557973894310174 no 244 0.060673094250893 62 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1209 2323-2347 50.3 µM 1.54266446255207 0.0565635596299176 no 245 0.0614561042956799 80 5412760 SGTC_1423 4048-0112 5.59 µM 1.53494772784665 0.0574862615802118 no 246 0.0623983342422625 89 X1423 SGTC_395 anisomycin 6.25 µM 1.53256888204111 0.0577730790477049 no 247 0.0626910567858219 91 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2493 resveratrol 26.09 µM 1.53188399910525 0.0578558636495602 no 248 0.0627755313512029 54 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2737 bleomycin 30.5 nM 1.53164501659504 0.0578847723801567 no 249 0.0628050287058528 94 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2741 miltefosine 3.04 µM 1.53086725148945 0.0579789340388704 no 250 0.0629011021924897 56 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3183 9108214 49.47 µM 1.52178702526385 0.0590871774817923 no 251 0.0640312267732666 40 4974831 SGTC_728 3030-5151 22.5 µM 1.51560549063127 0.0598510935209342 no 252 0.0648095689372196 78 3125388 SGTC_2399 5884133 200 µM 1.51358565240134 0.0601023758253915 no 253 0.0650654811628677 101 722445 SGTC_112 phenothiazine 287.218 µM 1.5124143277326 0.0602484749418137 no 254 0.06521424612697 79 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_956 1185-0240 191 µM 1.51126644054453 0.0603919202661519 no 255 0.0653602903053586 85 1416193 SGTC_1445 4239-0156 97.7 µM 1.51056322103766 0.0604799297811937 no 256 0.0654498852383021 90 4008346 SGTC_1306 1185-0270 9.02 µM 1.50979537672359 0.0605761418138533 no 257 0.0655478225637085 88 1548076 SGTC_210 3551-0445 56.827 µM 1.50970036544939 0.0605880551874972 no 258 0.0655599489978624 86 2865180 YOR207C RET1 SGTC_102 gallobenzophenone 83.616 µM 1.50790630734533 0.0608133546667964 no 259 0.065789254071008 101 70837 SGTC_1835 st008666 49.2 µM 1.50191364241915 0.0615706704445147 no 260 0.0665597064373224 70 690455 SGTC_2896 9052656 71.43 µM 1.49849902241087 0.0620054711512878 no 261 0.0670018232144847 140 6469436 SGTC_2387 9077560 195.08 µM 1.49612623944057 0.0623090178120205 no 262 0.0673103806476408 98 5303272 SGTC_2933 9026794 32.47 µM 1.49320640483627 0.062684137076143 no 263 0.0676915830405937 87 17586027 SGTC_1245 0418-0076 17.2 µM 1.49209345062733 0.0628275838369947 no 264 0.0678373242973116 88 6790114 SGTC_786 4544-0069 423 µM 1.4902098412325 0.0630709416306627 no 265 0.0680845347819204 108 748821 YLR208W SEC13 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.48696668863179 0.063491668615217 no 266 0.0685118045756043 138 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2331 7980721 200 µM 1.4827877678518 0.0640370073890801 no 267 0.0690654034979113 116 2981221 SGTC_1002 4049-0206 172 µM 1.48037364552911 0.0643536999394176 no 268 0.0693867796126885 107 4662749 SGTC_278 4092-0821 23.9 µM 1.48000052842516 0.0644027550769674 no 269 0.0694365528227878 83 877900 SGTC_1410 3909-8106 77.9 µM 1.47915698600674 0.0645137659301986 no 270 0.0695491813509357 117 1039210 SGTC_1745 st081495 74 µM 1.47912893285615 0.0645174602995311 no 271 0.0695529293813008 124 13842402 YBL026W LSM2 SGTC_727 3032-0951 202 µM 1.4767401864353 0.0648326418017773 no 272 0.0698726477352357 83 3652836 SGTC_767 0929-0023 86 µM 1.47478100890108 0.0650920353801535 no 273 0.0701357142802704 116 1204563 SGTC_1079 idarubicin 2.36 µM 1.47335916592888 0.0652807901152655 no 274 0.0703271073808271 103 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1254 0550-0035 264 µM 1.46949014176107 0.0657965669518191 no 275 0.0708499468835055 113 15121435 SGTC_291 SEC14.278 35.5 µM 1.46645095220622 0.0662039297386591 no 276 0.0712627370171972 95 1068044 SGTC_3142 9086498 49.47 µM 1.46294316564447 0.0666765271303139 no 277 0.0717414656101993 142 25236367 SGTC_2252 omeprazole 400 µM 1.46178032538022 0.0668337692743921 no 278 0.0719007086183507 64 4594 A proton pump inhibitor. SGTC_1803 st050068 52.4 µM 1.46153930421036 0.0668663966213915 no 279 0.0719337487037655 107 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1120 ficusin 1.78878 µM 1.4605544599227 0.0669998443273769 no 280 0.0720688758368622 91 6199 A DNA cross-linker. SGTC_2436 5633522 8.09 µM 1.45965641868107 0.0671217095792573 no 281 0.0721922625646422 103 5724242 SGTC_2341 7987486 176.74 µM 1.45740877003024 0.06742746949453 no 282 0.0725017888275281 93 1258686 SGTC_2986 9022445 71.43 µM 1.45653963808663 0.0675459904570682 no 283 0.0726217501687121 106 6459286 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.45460914807256 0.0678098215292772 no 284 0.0728887484914734 118 65057 A dermal irritant. YDR527W RBA50 SGTC_255 tunicamycin 200.472 nM 1.45334398317112 0.0679831569857355 no 285 0.0730641355621649 110 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_431 k089-0097 107 µM 1.45310890039567 0.0680154024446315 no 286 0.0730967601297639 111 5499420 SGTC_2106 5357045 167.29 µM 1.45245093843593 0.0681057154983432 no 287 0.0731881307383263 105 668842 SGTC_2193 5925765 200 µM 1.45061632515518 0.0683580267982931 no 288 0.0734433634367829 91 877370 SGTC_1361 1608-0041 5.61 µM 1.45000770218443 0.0684418888345361 no 289 0.0735281856957073 106 X1361 SGTC_2129 girgensonine 121.053 µM 1.44529724747766 0.0690936282323001 no 290 0.0741872053502835 130 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_27 0485-0001 32.618 µM 1.44416602832549 0.0692508538492111 no 291 0.0743461391875554 91 2054479 SGTC_886 0866-0150 153 µM 1.44150608426566 0.0696216394698821 no 292 0.0747208798479514 104 271463 SGTC_2789 5281112 71.43 µM 1.44107900271514 0.0696813150835548 no 293 0.0747811823958682 103 765948 SGTC_833 3852-0053 558 µM 1.43825175670041 0.0700773565379015 no 294 0.0751813173991759 119 3123681 SGTC_221 trifluoperazine 10.304 µM 1.43494983657426 0.0705420800368532 no 295 0.075650696359662 136 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2524 avocatin b 10.57 µM 1.4344515980522 0.0706124090477928 no 296 0.0757217160612653 63 6710748 SGTC_946 3434-1334 87.4 µM 1.43323828971435 0.0707838993532927 no 297 0.0758948753545175 118 4047976 SGTC_1229 0139-0193 12.2 µM 1.43304140461343 0.0708117574565278 no 298 0.0759230025486832 125 3090752 SGTC_528 3492-0019 172 µM 1.43288616902385 0.0708337283333623 no 299 0.0759451852498063 129 2869262 SGTC_862 0452-0056 10.2 µM 1.42796845675531 0.0715324585791767 no 300 0.0766504689175506 80 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.42301952355119 0.0722409520260756 no 301 0.0773652478289244 113 689007 SGTC_687 k029-0044 34.9 µM 1.41791619401989 0.0729771684541715 no 302 0.0781076169277448 69 5829338 SGTC_384 k007-0144 5.16 µM 1.41786498329982 0.0729845852081022 no 303 0.078115093717276 116 6824886 SGTC_899 1083-0020 478 µM 1.41483120569394 0.073424991864956 no 304 0.0785589961298613 110 767123 SGTC_515 4092-1064 102 µM 1.41221780478782 0.0738060004379582 no 305 0.0789429197660169 130 717353 SGTC_2859 9028643 45.46 µM 1.40597245117357 0.0747226312690164 no 306 0.0798661527040007 74 17151580 SGTC_1119 parthenolide 318.541 nM 1.40586328969573 0.0747387297997289 no 307 0.0798823620367524 124 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2518 prenyletin 46.28 µM 1.40564838994665 0.0747704297587649 no 308 0.0799142796617227 65 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2050 5263056 171 µM 1.3996403201056 0.0756608414007676 no 309 0.0808105267530451 132 763468 YGL055W OLE1 SGTC_265 mycophenolic acid 32.932 µM 1.39694630226916 0.0760627154442062 no 310 0.0812148596905682 98 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2550 chrysin dimethyl ether 71.87 µM 1.3923160014119 0.0767572239104967 no 311 0.0819133640438973 69 88881 An O-methylated flavonoid and antioxidant. SGTC_2119 5528445 120.635 µM 1.39033808392717 0.0770553614672166 no 312 0.0822131191847712 109 791935 SGTC_3226 9131256 49.47 µM 1.38794905352164 0.0774166398215946 no 313 0.082576279593935 89 17178073 SGTC_1351 1496-0003 46.5 µM 1.3852236231511 0.077830359213057 no 314 0.0829920497276195 104 3891978 SGTC_136 0097-0015 404.482 µM 1.38331058767767 0.0781217581289969 no 315 0.0832848264882649 118 4861337 SGTC_2856 9022925 19.48 µM 1.38284507960802 0.07819279065681 no 316 0.0833561865790228 114 4944862 SGTC_2576 guaiol 23.12 µM 1.38208299242464 0.0783091843360012 no 317 0.0834731099821673 119 227829 SGTC_2740 felodipine 17.08 µM 1.37399439484114 0.0795526662592382 no 318 0.0847217112775298 67 3333 L-type calcium channel blocker SGTC_2977 9011197 71.43 µM 1.3735716185578 0.0796180693352926 no 319 0.0847873564954998 117 2704722 SGTC_2505 galangin 7.89 µM 1.36665024009513 0.0806945925464718 no 320 0.0858674808612842 124 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2467 5474540 200 µM 1.36603886451329 0.0807902092611913 no 321 0.0859633826115858 122 5413519 SGTC_18 0111-0177 500 nM 1.3610714950512 0.0815702596715671 no 322 0.0867455483671867 124 721752 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.35843925307543 0.0819859088714304 no 323 0.0871621729759381 125 688664 SGTC_2064 5220758 200 µM 1.35675937087886 0.0822520068819662 no 324 0.087428840477229 136 788518 SGTC_716 1683-5115 658 µM 1.35490545522602 0.0825464267327247 no 325 0.0877238406880831 126 723597 SGTC_1654 st012436 41.8 µM 1.35399039601487 0.0826920391353601 no 326 0.0878697208796501 90 4323132 SGTC_945 3381-0768 11.3 µM 1.34647415646594 0.0838954132629982 no 327 0.0890748247435797 108 1126236 YIL048W NEO1 SGTC_1399 3562-5772 25 µM 1.34160112047671 0.0846825997558992 no 328 0.0898626813534659 103 23847490 SGTC_3195 9113082 49.47 µM 1.34012846110697 0.0849215786033279 no 329 0.090101792259361 105 17018038 SGTC_19 0279-0214 38.434 µM 1.3395256268022 0.0850195504950229 no 330 0.0901998087365531 125 3566274 YBR002C RER2 SGTC_2164 5685496 200 µM 1.33790226686769 0.0852837981707617 no 331 0.0904641490534337 99 759046 SGTC_1116 jasmonic acid  1.58368 µM 1.33786051608514 0.0852906023965321 no 332 0.0904709551335864 112 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3219 9131112 49.47 µM 1.33598824414437 0.0855961492879769 no 333 0.0907765578960471 130 17612988 YMR079W SEC14 SGTC_1192 1488-0095 21.4 µM 1.3334602249458 0.0860100108644226 no 334 0.0911904099835254 108 915875 SGTC_2221 6807166 181.081 µM 1.33110606866253 0.0863967540284399 no 335 0.0915770562095286 87 674925 SGTC_2756 carbadox 75.1 µM 1.3268311136593 0.0871023701171187 no 336 0.0922822778575862 138 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1251 0490-5699 265 µM 1.32594696168639 0.0872488422017152 no 337 0.0924286330533492 128 3883818 SGTC_967 1306-0166 352 µM 1.3179257516035 0.0885860789041215 no 338 0.093764252112225 140 4437607 SGTC_1004 4084-0029 199 µM 1.31124619245813 0.0897112471049065 no 339 0.0948873003965276 105 716894 YLR208W SEC13 SGTC_702 1488-0190 94 µM 1.31107728680933 0.0897398362697201 no 340 0.09491582677392 83 949357 SGTC_2995 9067767 71.4286 µM 1.30982489735576 0.0899520284773434 no 341 0.0951275392374064 95 11673567 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.30735668952998 0.0903713077771329 no 342 0.095545799679179 115 4213774 SGTC_670 4204-0025 119 µM 1.30714090116517 0.0904080330412378 no 343 0.0955824312293842 108 719039 SGTC_2055 5235184 200 µM 1.30618161716302 0.090571428805995 no 344 0.0957454013452768 121 2836034 SGTC_505 gw-5074 63.9 µM 1.30547420715952 0.0906920629936916 no 345 0.0958657121737663 122 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2147 5545932 89.7195 µM 1.30253053990124 0.0911953254322173 no 346 0.0963675425036958 150 797404 SGTC_2541 muurolladie-3-one 83.07 µM 1.30163668183888 0.091348552506153 no 347 0.0965203070191009 170 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3315 9136395 68.55 µM 1.30079273879581 0.0914933981311471 no 348 0.0966647040455786 162 16876844 SGTC_101 0490-5701 117.494 µM 1.30009562373144 0.0916131720440401 no 349 0.0967840986999052 103 4661669 SGTC_979 1426-2828 121 µM 1.29844030487041 0.0918980439082105 no 350 0.0970680383904441 133 747872 SGTC_1665 st014639 11.4 µM 1.29833305275664 0.0919165240509307 no 351 0.0970864565986129 129 981133 YIL048W NEO1 SGTC_1313 1220-0047 237 µM 1.29642672517363 0.0922454543738263 no 352 0.0974142548136165 133 3528706 SGTC_477 mead ethanolamide 10 µM 1.29613898641849 0.0922951782984824 no 353 0.0974638027105367 63 16061185 SGTC_939 1165-0479 45.3 µM 1.29583761885527 0.0923472786736082 no 354 0.0975157172704728 122 1377347 SGTC_669 0108-0021 26.2 µM 1.2942858962506 0.0926158848065486 no 355 0.097783343143079 120 17201 SGTC_1681 tripelennamine 100 µM 1.29401280045552 0.0926632179527704 no 356 0.0978304996890505 109 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1247 0448-0043 5.84 µM 1.29364804395832 0.0927264656980584 no 357 0.0978935096541336 138 3089013 YGL099W LSG1 SGTC_2678 equilin 100 µM 1.28842159474813 0.0936362261083015 no 358 0.09879962279018 111 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2611 pyromycin 23.93 µM 1.28800225593663 0.0937095044222461 no 359 0.0988725889450573 123 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_249 wiskostatin 11.211 µM 1.28773988721635 0.0937553741677491 no 360 0.0989182619016792 126 2775510 A n-wasp and actin depolymerizer. SGTC_3045 9092950 49.47 µM 1.28659973350385 0.0939548989994073 no 361 0.0991169183236566 99 44120432 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.28607968552078 0.0940460104437752 no 362 0.0992076265120018 107 2724278 An inhibitor of dopamine biosynthesis. SGTC_1908 st060353 56.5 µM 1.28347973499113 0.09450249480567 no 363 0.0996620274332893 148 4227716 SGTC_1699 st031318 29.054 µM 1.28077910290797 0.0949783837815822 no 364 0.100135633014646 138 5340658 SGTC_3004 9076122 71.4286 µM 1.27865302546146 0.0953542684076514 no 365 0.100509634201546 123 44782551 SGTC_67 0335-0847 266 µM 1.27664372692874 0.0957105123337937 no 366 0.100864028396272 147 4552207 YOR254C SEC63 SGTC_2642 cholecalciferol 100 µM 1.27305470048447 0.0963492732486066 no 367 0.101499315991854 102 9821465 A vitamin D precursor, similar to steriods. SGTC_3136 9095672 49.47 µM 1.27255812787704 0.0964378974449362 no 368 0.101587442475835 132 17217380 SGTC_1475 4092-1048 11.7 µM 1.27239524679709 0.0964669801630204 no 369 0.101616361029119 133 2881759 SGTC_275 trichlorophene 5.69 µM 1.26857367341123 0.0971511795530031 no 370 0.102296579452017 111 62616 SGTC_1924 st058459 75.1 µM 1.26432881933304 0.0979153287521453 no 371 0.103056014852915 112 688683 SGTC_154 3389-1638 511.116 µM 1.26318058029088 0.098122787134869 no 372 0.103262145114972 131 5238686 SGTC_2342 7990637 118.86 µM 1.26268100692766 0.0982131481450183 no 373 0.103351921219099 151 2033102 YER133W GLC7 SGTC_155 k072-0202 43.6 µM 1.26137026536201 0.0984505200461233 no 374 0.103587738080502 146 5857737 SGTC_959 1222-0044 107 µM 1.26078445616982 0.0985567442938704 no 375 0.103693257767938 130 6083612 SGTC_1495 4469-0029 237 µM 1.26001359594476 0.0986966514926374 no 376 0.103832228825934 129 793680 SGTC_2330 7979373 200 µM 1.25871351048671 0.0989329395878936 no 377 0.10406691483914 130 1863007 SGTC_3061 glucosamine 200 µM 1.2574825758015 0.0991570408369613 no 378 0.104289472279445 111 91431 and experimental redox chemotherapeutic SGTC_85 0868-0259 160.055 µM 1.25691634246975 0.0992602525979668 no 379 0.1043919650715 125 83173 SGTC_1061 3448-9325 110 µM 1.25662350755989 0.0993136607053229 no 380 0.104444999173962 136 723482 SGTC_2056 5235370 200 µM 1.25302864362734 0.0999710155721113 no 381 0.105097641315265 120 5511916 SGTC_910 3454-3003 490 µM 1.25077404352001 0.100384908569739 no 382 0.105508463713546 163 820824 SGTC_2439 5492030 7.2 µM 1.24414017478661 0.101609985130055 no 383 0.106723988638369 139 5722370 SGTC_581 0958-0271 211 µM 1.24333799464417 0.101758858392904 no 384 0.106871654381208 107 4591145 SGTC_2311 7694451 200 µM 1.24258794728057 0.101898200138584 no 385 0.107009856792908 168 2163142 SGTC_907 3448-6986 75.5 µM 1.23998477058655 0.10238288849341 no 386 0.107490513587495 154 590582 SGTC_2077 5212015 200 µM 1.23909211780849 0.1025494779102 no 387 0.107655692860343 125 780900 SGTC_3231 9132313 49.47 µM 1.2375516884186 0.102837420539093 no 388 0.107941168709126 131 4905967 SGTC_2004 4023728 41.89 µM 1.23742930906059 0.102860321295346 no 389 0.107963871680468 174 360084 YDR527W RBA50 SGTC_534 k292-0788 63.4 µM 1.23077929343252 0.104110310595899 no 390 0.109202711016658 170 4146317 SGTC_3177 9107506 49.47 µM 1.22887194497933 0.104470854853986 no 391 0.109559910831193 118 8897194 SGTC_464 bw-b 70c 158 µM 1.22484016510866 0.105235953768487 no 392 0.110317724193719 142 5353454 SGTC_3218 9131285 49.47 µM 1.22455234412082 0.105290727345247 no 393 0.110371966422148 146 17156417 SGTC_1096 rimcazole 32.2 µM 1.22414946608612 0.105367431412297 no 394 0.110447924210796 120 18528119 A dopamine reuptake inhibitor. SGTC_2941 9056145 11.23 µM 1.22363761828995 0.105464940554671 no 395 0.110544480976272 123 2119517 SGTC_2588 indole-3-carbinol 100 µM 1.22309104075907 0.105569137897234 no 396 0.110647656071353 135 3712 Induces cell cycle arrest. SGTC_732 3970-1727 52.7 µM 1.22224063984287 0.105731402890481 no 397 0.110808319794987 145 1275699 SGTC_2691 st077356 60.2 µM 1.21917428714184 0.1063179907183 no 398 0.111389024510147 148 2839272 SGTC_3146 9095609 49.47 µM 1.21658884747157 0.106814404038126 no 399 0.111880344046544 128 17173999 SGTC_822 1487-0950 154 µM 1.21368595432491 0.107373760104363 no 400 0.112433834961407 131 1958375 SGTC_3062 9077494 49.47 µM 1.21306781438451 0.107493141164482 no 401 0.112551947113573 131 16459633 SGTC_2148 5546263 113.568 µM 1.21290065904868 0.107525440216756 no 402 0.112583901824694 135 792097 SGTC_2742 clothiapine 36.27 µM 1.2125350150256 0.107596117175972 no 403 0.11265382376203 96 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1875 nocodazole 6 µM 1.21145481965648 0.107805108448309 no 404 0.11286057014744 139 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2488 5268135 45.7 µM 1.21056313146206 0.10797784839567 no 405 0.113031440761377 162 1270356 YLR208W SEC13 SGTC_576 1073-0113 22.7 µM 1.21050057064299 0.107989975303619 no 406 0.11304343596623 181 5439563 SGTC_41 0478-0632 82.643 µM 1.20634686743479 0.108797332432277 no 407 0.113841886813933 154 3750424 SGTC_2444 5485484 36.41 µM 1.20458131755385 0.109141814388553 no 408 0.114182486264341 159 6790631 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.20249561500052 0.109549771357277 no 409 0.114585782013507 149 390807 SGTC_2788 5282734 71.43 µM 1.20010870846568 0.110017985152952 no 410 0.115048561930476 151 743706 SGTC_3330 9141424 71.43 µM 1.19846550598307 0.110341147875143 no 411 0.115367921959288 118 27261020 SGTC_2462 5162487 171.77 µM 1.1961674546813 0.11079423815711 no 412 0.115815609245954 139 2259986 SGTC_212 3807-4682 38.772 µM 1.19554011738429 0.110918157051953 no 413 0.115938035970594 151 3125501 YBL034C STU1 SGTC_2296 7971656 126.45 µM 1.19449064515396 0.111125682823507 no 414 0.116143048948648 124 666570 SGTC_2024 5144227 134 µM 1.1936070748706 0.1113006181138 no 415 0.116315852598893 132 3475211 SGTC_1105 epirubicin 18.1 µM 1.19285316785248 0.1114500375774 no 416 0.116463441609842 151 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_761 k216-0224 480 µM 1.19057862724616 0.111901706494015 no 417 0.116909523054568 158 1340404 SGTC_2602 kawain 100 µM 1.18744088763532 0.112526932060628 no 418 0.117526880068554 148 5369129 SGTC_1368 1852-0141 284 µM 1.18622466444932 0.11276994633803 no 419 0.117766794196632 141 2838987 SGTC_2888 9058547 12.99 µM 1.18146885057073 0.113723805291857 no 420 0.11870826034792 115 16476514 SGTC_2175 5807670 165.306 µM 1.17949992309599 0.114120385635937 no 421 0.119099583651224 109 241186 SGTC_1111 tnp00062 510.699 nM 1.17812932476031 0.114397031742014 no 422 0.11937252643865 137 676306 SGTC_218 alverine citrate 93.75 µM 1.17693469192435 0.114638549548343 no 423 0.119610786993078 145 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_973 1325-0077 65.9 µM 1.17645148653255 0.11473634172763 no 424 0.119707253894831 137 2835149 SGTC_961 1252-1571 372 µM 1.17391233950075 0.115251195390875 no 425 0.120215069700308 146 6813498 SGTC_341 1486-1430 230 µM 1.17201615710538 0.115636747115592 no 426 0.120595284683307 193 2054753 YPL210C SRP72 SGTC_1630 st005209 31.3 µM 1.1719624842122 0.115647673770458 no 427 0.120606059267815 141 3367314 SGTC_2014 4013930 200 µM 1.17162074314489 0.115717262155466 no 428 0.120674678099597 161 64556 SGTC_3338 9144300 39.5675 µM 1.16860705642583 0.116332223916047 no 429 0.121280991957381 118 4901274 SGTC_2711 st079103 59.1 µM 1.16719326964138 0.116621513648686 no 430 0.121566164140135 134 54693780 SGTC_565 1418-0001 44.5 µM 1.16566189689804 0.116935439015804 no 431 0.121875585718561 147 2862145 SGTC_2076 5212012 200 µM 1.16416964167537 0.117241921138089 no 432 0.122177635230894 133 604802 SGTC_1717 st033143 58.0435 µM 1.16406572155429 0.117263285615831 no 433 0.122198689408805 131 674616 SGTC_2185 6113692 200 µM 1.16266268909273 0.117551998816087 no 434 0.122483192629987 150 874150 SGTC_3271 9137798 49.47 µM 1.1626113390625 0.117562575059798 no 435 0.122493614063276 122 6498326 SGTC_1501 4491-0275 38.4 µM 1.16143010922342 0.117806051561414 no 436 0.122733515178061 148 5104718 SGTC_2292 7671323 168.05 µM 1.1588057156313 0.118348271181308 no 437 0.12326769360527 189 937504 SGTC_117 lucigenin 22.078 µM 1.15841985504735 0.118428141433293 no 438 0.123346370206756 151 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2520 obtusaquinone 4.71 µM 1.15781598705296 0.118553214044653 no 439 0.123469568911078 163 5967872 SGTC_1320 1313-0481 95.3 µM 1.15760440347254 0.118597059126119 no 440 0.123512755720839 123 6813365 YLR208W SEC13 SGTC_564 3555-0129 330 µM 1.15303080910587 0.119547617069082 no 441 0.124448869530969 144 563260 SGTC_3103 9120822 49.47 µM 1.15278651330723 0.119598541323575 no 442 0.124499010682442 184 17141819 SGTC_2669 eugenol 100 µM 1.1509337840365 0.119985246847932 no 443 0.124879738878694 108 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1706 st031321 9.9705 µM 1.15050758605524 0.120074328331888 no 444 0.124967435765874 149 6103185 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.14830782382763 0.120534851270848 no 445 0.125420755209531 160 5106787 A p450 inhibitor. SGTC_2565 isoliquiritigenin 100 µM 1.14749732224063 0.120704843926731 no 446 0.125588069599311 143 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1508 1080-0625 72.9 µM 1.14422861154855 0.121392128014724 no 447 0.126264420171184 148 767111 SGTC_1872 amphotericin b 148 nM 1.14333912236678 0.121579628673081 no 448 0.126448908841608 143 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_731 3966-0296 387 µM 1.14188460992319 0.121886672308419 no 449 0.126750993283903 142 660956 SGTC_2496 diffractaic acid 79.83 µM 1.13782058450988 0.122747462903737 no 450 0.127597703870189 149 94870 An apoptosis inducer which activates caspases. SGTC_3125 9127534 49.47 µM 1.13772462862935 0.122767838462046 no 451 0.127617742997399 132 1639235 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.13336636157195 0.12369578753936 no 452 0.128530217099322 164 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2763 lisinopril 49.32 µM 1.13203579436096 0.12398006391138 no 453 0.128809693044851 147 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_8 0354-0001 70 µM 1.12845406736298 0.124747572548186 no 454 0.129564102434671 168 4993152 SGTC_1878 temozolomide 1 mM 1.12762849286828 0.124924950254408 no 455 0.129738424129117 150 5394 DNA alkylating agent. SGTC_219 mitoxanthrone 164.414 µM 1.12700957852795 0.125058041777444 no 456 0.129869215602167 158 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3346 9158254 43.5805 µM 1.12437500274845 0.125625689637432 no 457 0.130426986014892 183 17639500 SGTC_2927 9011802 47.9 µM 1.12394152962432 0.125719258070245 no 458 0.130518915825899 142 43912568 SGTC_1020 4335-0961 93.3 µM 1.11993698491479 0.126585968651582 no 459 0.131370308086975 172 669075 SGTC_1996 st072960 66.8 µM 1.11907738829897 0.12677255390705 no 460 0.131553562703327 158 1719405 SGTC_3270 9137563 49.47 µM 1.11830674264447 0.126939994062199 no 461 0.131718004087612 143 17015724 SGTC_232 clozapine 119 µM 1.11643179204088 0.127348012055548 no 462 0.132118675654572 148 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_282 k297-0036 65.7 µM 1.11636046882803 0.127363551069547 no 463 0.132133933794816 161 5061378 SGTC_2531 methyl deoxycholate 70.07 µM 1.11383630720006 0.127914333362155 no 464 0.132674708949557 162 16667744 Haematoxylin. SGTC_161 4065-0411 162.148 µM 1.11367136599115 0.127950381720401 no 465 0.132710098859994 174 1906281 YLR208W SEC13 SGTC_666 0272-0154 136 µM 1.11247597247188 0.128211849235044 no 466 0.132966777711754 176 6870312 SGTC_740 k014-0057 261 µM 1.11084945013447 0.128568212806483 no 467 0.133316578557427 176 4012779 SGTC_367 0335-0881 7.1 µM 1.1087280107324 0.129034042597642 no 468 0.133773767203338 172 23828853 SGTC_1464 k208-0027 110 µM 1.10828025927158 0.129132510122178 no 469 0.133870399117747 167 X1464 SGTC_1901 st060216 58.6 µM 1.10751475227091 0.129300977686967 no 470 0.134035718853458 146 688792 SGTC_911 3456-4043 236 µM 1.10340681456449 0.130207626354717 no 471 0.134925269334854 158 914281 SGTC_1420 4'-methoxyflavone 42 µM 1.10190897446598 0.130539301221344 no 472 0.135250623291109 151 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2914 7968218 45.32 µM 1.09362288612257 0.132384688024758 no 473 0.137060203772218 125 2977111 SGTC_348 k064-0012 10.7 µM 1.09323845042216 0.132470739583658 no 474 0.137144559499077 166 5066323 SGTC_2886 9058944 51.95 µM 1.09321802569891 0.132475312503663 no 475 0.137149042235049 104 4949929 SGTC_1746 st038117 42 µM 1.0928656041733 0.132554233785459 no 476 0.137226406055732 166 2898218 SGTC_1138 3761-0006 1.03 µM 1.09252175911594 0.132631265666964 no 477 0.137301915887362 140 12061087 SGTC_489 paxilline 115 µM 1.09168580323218 0.132818674132315 no 478 0.137485613680556 156 105008 A toxic potassium channel blocker. SGTC_2708 st078559 56 µM 1.09060433310444 0.133061393558445 no 479 0.137723511040535 136 17250902 SGTC_3030 9087619 49.47 µM 1.09006267363823 0.133183075421653 no 480 0.137842768586664 179 25236973 SGTC_1590 st077108 57.8 µM 1.08723961434129 0.133818505048444 no 481 0.138465463880763 149 5489485 SGTC_478 N-arachidonylglycine 10 µM 1.08714414267276 0.133840030700718 no 482 0.13848655596711 103 5283389 SGTC_2556 citropten 84.59 µM 1.08379360898542 0.134596971054856 no 483 0.13922815976226 143 2775 A potential DNA crosslinker. SGTC_1071 trifluoperazine 6.31 µM 1.08146762438706 0.135124173774574 no 484 0.139744577336718 178 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2035 5154463 94.595 µM 1.08129508900389 0.135163336612226 no 485 0.139782935638673 204 2769623 SGTC_444 curcumin 90.4 µM 1.08010959993826 0.135432634558366 no 486 0.1400466887233 166 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1462 k081-0014 26.5 µM 1.07979880263162 0.135503296659159 no 487 0.140115892253902 132 3270634 SGTC_552 k242-0005 476 µM 1.07765915864759 0.135990446372686 no 488 0.140592945505273 175 4088318 SGTC_1571 st070080 73.4 µM 1.07582584110853 0.13640880501165 no 489 0.141002576503877 155 4315245 SGTC_1994 st072947 40.9 µM 1.07224904352522 0.137227553891572 no 490 0.141804093746022 168 5286565 YDL195W SEC31 SGTC_2335 9018011 154.17 µM 1.07143537556818 0.137414274691059 no 491 0.141986856882342 163 6458208 SGTC_3021 9087658 49.47 µM 1.07069693455867 0.137583882478589 no 492 0.142152860791275 142 25237042 SGTC_2785 7756463 72.73 µM 1.06835504801329 0.13812272031341 no 493 0.142680192973181 207 2201551 SGTC_1382 3002-2117 298 µM 1.06792268140674 0.138222359433941 no 494 0.142777695179375 167 1497314 SGTC_2944 9067346 25.62 µM 1.06791704407174 0.13822365888442 no 495 0.142778966741908 177 6473075 SGTC_692 k241-0027 77.8 µM 1.06779222552376 0.138252432684589 no 496 0.142807122891055 159 3600480 SGTC_1421 4029-0249 71.4 µM 1.06752395072677 0.138314290561069 no 497 0.142867652120989 188 2894095 SGTC_1735 st034310 56.75 µM 1.0639661638839 0.139136416983003 no 498 0.143672013972511 183 871153 SGTC_2619 obliquin 87.91 µM 1.06317203577319 0.139320375660742 no 499 0.143851970741889 173 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3298 9116858 71.43 µM 1.06310518045492 0.139335870151353 no 500 0.143867127711589 183 2506942 SGTC_1114 scopoletin 1.73284 µM 1.06219615723447 0.139546663106891 no 501 0.144073322003346 158 5280460 A coumarin with genotoxic properties. SGTC_397 arbidol 50 µM 1.06138104028185 0.13973586452259 no 502 0.144258384864833 158 131410 A RNA synthesis inhibitor. SGTC_2117 5521686 200 µM 1.06129734520315 0.13975530132985 no 503 0.144277395930339 169 803312 SGTC_1066 ketoconazole 628 nM 1.06031892753078 0.139982659098045 no 504 0.144499765598172 177 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1220 1838-0075 193 µM 1.05948179504225 0.140177385432048 no 505 0.144690207930289 163 5529645 SGTC_465 cgp-37157 41 µM 1.05934852816825 0.140208401759949 no 506 0.144720540890399 143 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2757 clomiphene 4.22 µM 1.056475241917 0.140878259803696 no 507 0.145375573105976 205 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2647 atorvastatin 60.16 µM 1.05515926926035 0.141185780273446 no 508 0.145676244444778 149 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1074 carmofur 3.8 µM 1.05418958451474 0.141412670172344 no 509 0.145898063816984 184 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_788 1182-0090 188 µM 1.0531383526282 0.141658919741248 no 510 0.146138793720638 170 5715185 SGTC_3262 9137218 49.47 µM 1.05272256184528 0.141756398258615 no 511 0.146234082532229 123 17650664 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.05270207359433 0.141761202724263 no 512 0.146238779003588 170 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_895 0964-0006 13.7 µM 1.05117773425173 0.14211896748747 no 513 0.146588483699924 208 6738897 SGTC_1758 st042942 75.2445 µM 1.05083064063648 0.142200516229076 no 514 0.146668190196428 181 669317 SGTC_404 fumagillin 50 µM 1.04776710116215 0.142921659954069 no 515 0.147372961715259 178 12015870 A methionine aminopeptidase binder. SGTC_1826 st055655 41.6 µM 1.04774075961695 0.142927871335837 no 516 0.147379031448612 159 676168 SGTC_1579 chlormadinone acetate 49.4 µM 1.04300918051244 0.144046545826859 no 517 0.148472020437435 179 45114258 A steroidal progestin. SGTC_2477 5967686 25.23 µM 1.04241142393157 0.144188290756041 no 518 0.14861048614506 171 776118 SGTC_1250 0485-0349 40.2 µM 1.04000911186295 0.144758894775379 no 519 0.14916783368254 167 6842794 YDL195W SEC31 SGTC_2255 7941087 197.44 µM 1.03821297582365 0.145186510386227 no 520 0.149585456464049 163 935561 SGTC_402 epigallocatechin gallate 10 µM 1.03621507518121 0.145663158808204 no 521 0.150050907656512 205 65064 An antioxidant. SGTC_57 miconazole 162.5 nM 1.03600300285138 0.14571381558079 no 522 0.150100370803723 188 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1169 aniline yellow 25.8 µM 1.03363401504231 0.146280490156251 no 523 0.150653645639298 186 6051 A DNA damaging agent. SGTC_2069 5228469 200 µM 1.03314693788384 0.146397184792624 no 524 0.150767570153833 183 2835210 SGTC_1314 1222-0010 41.1 µM 1.03247166592561 0.14655907076783 no 525 0.150925607196343 168 3526027 SGTC_2627 acetyl isogambogic acid 100 µM 1.03235060498677 0.146588105945559 no 526 0.15095395130316 167 6857789 A caspase activator and apoptosis inducer. SGTC_2205 7238770 200 µM 1.03066132846403 0.146993663715197 no 527 0.151349832761146 166 279867 SGTC_2115 tiliquinol 12.7705 µM 1.03024605034675 0.147093477882262 no 528 0.151447258703336 182 71208 A bioactive hydroxyquinoline. SGTC_1935 st074532 41.6 µM 1.03010939579482 0.147126333420737 no 529 0.15147932753618 192 2829742 SGTC_2692 st077426 47.7 µM 1.02838617269379 0.147541066180872 no 530 0.151884105097799 177 25238571 SGTC_645 0845-0943 5.41 µM 1.0281247840753 0.147604043628763 no 531 0.15194556684977 167 1885106 SGTC_2327 6189656 200 µM 1.02812030300181 0.147605123429419 no 532 0.151946620653398 172 5349088 SGTC_2829 7992743 58.44 µM 1.02755652557218 0.147741018631584 no 533 0.152079241610117 167 16462845 SGTC_1792 st045773 43.6 µM 1.02710286964643 0.147850430514819 no 534 0.152186013784317 101 2919270 SGTC_357 1325-0123 420 µM 1.0212273273266 0.149272383612418 no 535 0.153573374016778 189 1098503 SGTC_2246 7293507 91.5585 µM 1.01961379347049 0.149664471409257 no 536 0.153955830319511 186 887656 SGTC_2103 5378138 10 µM 1.01902957728031 0.149806604893077 no 537 0.154094462497081 177 244142 SGTC_3180 9109287 49.47 µM 1.01826843857188 0.149991916734946 no 538 0.154275201529233 194 18891271 SGTC_1034 k072-0165 12.7 µM 1.01726583877677 0.150236249462697 no 539 0.154513491475658 199 5835461 SGTC_3127 9126946 49.47 µM 1.01678698313085 0.150353039731835 no 540 0.154627387879079 164 27243249 SGTC_801 0866-0028 10.1 µM 1.01420740245727 0.150983225832201 no 541 0.155241898575927 172 6849771 SGTC_3042 9091578 49.47 µM 1.01349021514958 0.15115874502963 no 542 0.155413033762408 169 25236497 SGTC_3291 9121177 71.43 µM 1.01275362193183 0.15133915474125 no 543 0.15558892911892 163 17015612 SGTC_1562 morin hydrate 59.1 µM 1.01130160546208 0.151695208337858 no 544 0.15593604895234 168 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2474 5321570 43.32 µM 1.01001519695569 0.152011117415515 no 545 0.156244004601775 177 2841384 SGTC_3039 9090270 49.47 µM 1.00886160619034 0.152294781215194 no 546 0.156520505283356 160 17173750 SGTC_2525 harmine 47.85 µM 1.00833135392611 0.152425286137346 no 547 0.156647707859165 166 5280953 A monoamine oxidase inhibitor SGTC_3179 9107801 49.47 µM 1.00553316445056 0.153115201458207 no 548 0.157320094178414 155 4818259 SGTC_779 1360-0071 233 µM 1.0044818162433 0.153374953596812 no 549 0.157573215793649 189 7566 SGTC_2345 9052315 157.45 µM 1.00280339012858 0.153790239884619 no 550 0.157977866413194 176 6469265 SGTC_2753 fluvastatin 17.09 µM 1.00252714022056 0.153858662565792 no 551 0.158044532645983 183 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2585 alliin 100 µM 1.00218601366233 0.153943181951456 no 552 0.158126880768709 172 87310 A garlic compound which reacts with lipids. SGTC_2476 5806916 10.51 µM 1.0014781896843 0.154118654296583 no 553 0.158297839660903 179 2870194 SGTC_99 0109-0120 622.8 µM 1.00127574982182 0.154168864256069 no 554 0.15834675673094 175 759414 SGTC_3060 1327-0027 12.5 µM 0.999321954978296 0.154654008484855 no 555 0.158819376599033 180 16000455 YPR107C YTH1 SGTC_49 0717-0965 32.132 µM 0.997326074176507 0.155150643596838 no 556 0.159303130729985 185 5889349 YGL099W LSG1 SGTC_556 4058-0063 51.5 µM 0.996891595249398 0.15525889440017 no 557 0.159408565861534 182 6615692 SGTC_1070 indatraline 8.81 µM 0.996022982947939 0.155475459333682 no 558 0.159619489208821 194 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_296 1222-0039 74.9 µM 0.993917776698764 0.15600116193567 no 559 0.16013144954749 159 5984176 SGTC_3065 9113888 49.47 µM 0.993630503485972 0.156072989242075 no 560 0.160201394019473 169 16648368 SGTC_697 0508-1955 564 µM 0.993315249386763 0.156151837724555 no 561 0.160278174178935 169 6243113 SGTC_1966 st070145 16.1 µM 0.993024293656975 0.156224632206583 no 562 0.160349057807177 200 3748532 SGTC_936 3005-4620 401 µM 0.991881872104664 0.156510671900456 no 563 0.160627576551687 183 777207 SGTC_1216 1165-0504 9.65 µM 0.991504253725952 0.156605295833962 no 564 0.16071970815325 184 6304004 SGTC_1047 2043-3044 82 µM 0.985915590741185 0.158010110133831 no 565 0.162087267785525 211 669592 SGTC_69 0096-0274 206.684 µM 0.98527775323066 0.158170966820594 no 566 0.162243828616628 237 6741392 SGTC_2432 5630864 12.22 µM 0.979165136327236 0.159717960182884 no 567 0.163749195897027 185 5714970 SGTC_1380 2291-0730 164 µM 0.972726270952379 0.161358191783902 no 568 0.165344682415573 191 2999191 SGTC_3336 9143619 71.43 µM 0.970019419910873 0.162051001334337 no 569 0.166018406130317 179 45595730 SGTC_2151 5563267 85.4165 µM 0.968382456942444 0.162470915278948 no 570 0.166426698775955 213 5310824 SGTC_2965 9082772 38.63 µM 0.965210607284887 0.163286571961249 no 571 0.167219667560463 129 16459634 SGTC_2101 5377231 179.231 µM 0.959130955338599 0.164857407806761 no 572 0.168746388860603 194 2844213 SGTC_3133 9127736 49.47 µM 0.958110854521442 0.165121933063779 no 573 0.169003431294921 179 27243420 SGTC_1450 4112-4260 37.6 µM 0.956929252901135 0.165428680813403 no 574 0.16930148248121 204 1633175 SGTC_1040 k898-0338 155 µM 0.953299678137218 0.166373234433395 no 575 0.170219127267751 216 20969351 SGTC_2981 9013952 38.96 µM 0.953271550598048 0.166380567862409 no 576 0.170226251014912 198 2996344 SGTC_1012 4112-3522 18 µM 0.950877026992309 0.167005634660711 no 577 0.170833402483793 190 3112398 SGTC_467 ro 31-8220 72.8 µM 0.948940522713312 0.167512246153199 no 578 0.171325431563514 199 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1434 4073-0095 163 µM 0.948728801210563 0.167567694878752 no 579 0.171379280874234 202 24133745 SGTC_1503 4585-0012 61.3 µM 0.947515569052979 0.16788566182923 no 580 0.171688063299492 176 2922052 SGTC_594 1487-1584 10.8 µM 0.945942431537734 0.168298531623939 no 581 0.172088974868819 202 5013332 SGTC_1022 4477-0945 21.3 µM 0.945046531757798 0.168533952059631 no 582 0.172317560320822 181 4648966 SGTC_3102 9121669 49.47 µM 0.942460025297074 0.169214809674528 no 583 0.172978584023654 214 41905072 SGTC_2196 6573537 42.6665 µM 0.938801331548589 0.170180915196947 no 584 0.173916377574101 209 2903087 SGTC_3283 9109332 35.8195 µM 0.936662988921853 0.170747193826763 no 585 0.174465970009018 176 17027281 SGTC_2626 ethyl orsellinate 100 µM 0.935792130752564 0.170978160795562 no 586 0.174690111961583 214 75653 A natural product. SGTC_791 1348-1292 225 µM 0.934349881776913 0.171361110071907 no 587 0.175061720701154 201 5437054 SGTC_2746 daunorubicin 9.88 µM 0.93398088658197 0.171459174541902 no 588 0.175156876221151 164 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_866 0495-0101 262 µM 0.93396083921724 0.171464503373256 no 589 0.175162046922778 183 635694 SGTC_1334 1486-0610 236 µM 0.932345521587343 0.171894222112789 no 590 0.175578994673065 199 3742339 SGTC_1400 3771-8998 51.5 µM 0.932063254867533 0.171969383314499 no 591 0.175651918205739 171 670767 SGTC_3024 9090631 49.47 µM 0.931869453180869 0.172021000438393 no 592 0.17570199793029 182 25236383 SGTC_1319 1306-0155 43.7 µM 0.928487879788774 0.172923239881013 no 593 0.176577275980526 210 3122360 SGTC_1969 st069479 40.1 µM 0.928091726554327 0.17302913470619 no 594 0.176679995440086 205 3895485 SGTC_128 0906-2981 13.371 µM 0.926423947752339 0.173475397815972 no 595 0.177112851766674 229 6740226 SGTC_2919 7978188 46.38 µM 0.925080160589714 0.173835499888666 no 596 0.17746210601791 190 2980291 SGTC_2819 7996655 46.38 µM 0.924443459868336 0.174006285972185 no 597 0.177627738104294 179 6456960 SGTC_864 0469-0573 172 µM 0.924353104212519 0.1740305312567 no 598 0.177651251234302 208 689425 SGTC_1813 st051246 8.6015 µM 0.923622922348809 0.174226540980019 no 599 0.177841337532614 183 5291959 SGTC_1280 0880-0253 10.1 µM 0.923618126401741 0.174227828865692 no 600 0.177842586472664 217 6836607 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.921994891806162 0.174664073728487 no 601 0.178265620079788 213 688788 SGTC_842 0271-0008 11.1 µM 0.921527487713141 0.174789817230506 no 602 0.178387548456843 204 1221709 SGTC_1708 st033234 31.827 µM 0.920947239438343 0.174945998589708 no 603 0.178538986774307 195 674664 SGTC_285 1486-1325 46 µM 0.91993511827492 0.175218636019174 no 604 0.178803332826298 210 22310230 SGTC_2921 7974240 10.71 µM 0.919124675187477 0.175437141114918 no 605 0.179015182082631 201 2979074 YDR527W RBA50 SGTC_277 nystatin 15.5 µM 0.918009035339772 0.175738213302365 no 606 0.179307067785948 203 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2038 4100038 30.985 µM 0.91773868597998 0.175811220383116 no 607 0.179377844517906 206 3596803 SGTC_1655 st012546 55.1 µM 0.917589699015646 0.175851462101449 no 608 0.179416856408863 191 720985 YLR208W SEC13 SGTC_2286 7945697 125 µM 0.917283256113855 0.175934251365595 no 609 0.179497114539077 194 1245733 SGTC_2522 biochanin a 4.94 µM 0.916735242092729 0.176082365520945 no 610 0.179640696977776 193 5280373 A possible chelator. SGTC_884 0851-0618 334 µM 0.916319189097261 0.176194866689344 no 611 0.179749753144687 217 9642473 SGTC_2955 9076254 12.21 µM 0.914602250100469 0.176659609897163 no 612 0.180200238520167 191 16459619 SGTC_756 0508-1999 28.3 µM 0.913009501604712 0.177091429431176 no 613 0.180618772163321 204 6753853 SGTC_1041 0206-0046 107 µM 0.912935667680347 0.17711146314507 no 614 0.180638188606669 212 50494 SGTC_826 1683-5028 118 µM 0.911424512732917 0.177521806562577 no 615 0.181035871403897 200 722377 SGTC_169 k015-0017 16.025 µM 0.908933150548773 0.178199627267862 no 616 0.181692706880778 225 1840002 SGTC_656 4090-1979 187 µM 0.908780078656944 0.178241326402394 no 617 0.181733112100835 212 22330961 SGTC_283 0987-0079 11.7 µM 0.90660337590326 0.178834959018385 no 618 0.182308287944225 201 411556 SGTC_2983 9022671 12.99 µM 0.903766378269813 0.179610533563486 no 619 0.183059646650563 194 6405161 SGTC_146 3448-8650 53.125 µM 0.90273520576929 0.179892957081258 no 620 0.183333223411983 230 2891488 YIL048W NEO1 SGTC_2479 5617353 43.85 µM 0.900779822956285 0.180429274113849 no 621 0.183852698780301 209 2731746 SGTC_928 2764-0428 58.7 µM 0.899784745474205 0.180702585949494 no 622 0.184117406948982 216 662578 SGTC_2659 sanguinarine 24.21 µM 0.899644191785497 0.180741211881637 no 623 0.184154815822867 208 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1731 st035964 63 µM 0.899131939284942 0.180882029156162 no 624 0.184291193719906 211 6739575 SGTC_1736 st036774 51 µM 0.898763215000084 0.180983433336949 no 625 0.184389398732787 226 1272247 SGTC_3354 9151612 71.43 µM 0.897960202797861 0.181204395823089 no 626 0.184603383427243 187 27261949 SGTC_497 capsazepine 133 µM 0.897944404955357 0.181208744562637 no 627 0.184607594745303 209 2733484 A calcium channel blocker. SGTC_3040 9091894 49.47 µM 0.897369263055586 0.181367110835988 no 628 0.184760954172064 180 25236966 SGTC_2096 5468907 200 µM 0.896128831457923 0.181708960609508 no 629 0.185091980094568 203 759785 SGTC_2361 9034121 116 µM 0.894742216479448 0.182091573831711 no 630 0.185462452829047 231 6496917 SGTC_1797 st048695 56.8 µM 0.894698230225636 0.182103719339292 no 631 0.185474212506322 225 592262 YIL048W NEO1 SGTC_563 tetrahydrosecaminediol 614 µM 0.893658073850861 0.182391075437405 no 632 0.185752432046572 189 334274 A psychoactive constituent of the cannabis plant. SGTC_1344 1488-0097 29.1 µM 0.893620939708702 0.182401339439393 no 633 0.185762369417614 233 747966 SGTC_935 2996-0153 430 µM 0.89258920036379 0.182686659954097 no 634 0.186038602349567 222 23738523 SGTC_3248 9135562 49.47 µM 0.891663569219819 0.182942873979429 no 635 0.1862866429735 212 17650701 SGTC_2884 9058502 51.95 µM 0.891113800130236 0.183095155752806 no 636 0.186434061096533 194 6471554 SGTC_2667 digitoxin 100 µM 0.890682059589602 0.183214799950945 no 637 0.186549881032845 178 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_385 1494-0393 12.4 µM 0.890004918055412 0.183402548004152 no 638 0.186731622653323 223 3090647 SGTC_2263 7948595 193.29 µM 0.88958769082514 0.183518290460996 no 639 0.186843659042702 198 2971371 SGTC_1496 4469-0713 57.4 µM 0.887840585455794 0.184003446954537 no 640 0.18731325405776 206 746691 SGTC_937 3122-0005 46.7 µM 0.886456142544102 0.184388461710183 no 641 0.187685888707306 227 759535 SGTC_1693 xanthone 101.9 µM 0.885630085562082 0.184618427424679 no 642 0.187908446991189 245 7020 An insecticide. SGTC_813 k007-0158 173 µM 0.884554612469847 0.184918095117693 no 643 0.188198447637828 209 6523916 SGTC_1404 3909-7820 48.3 µM 0.88438646648318 0.184964974291206 no 644 0.188243813050045 204 23741373 SGTC_3010 9080089 71.4286 µM 0.883954860157611 0.185085340121869 no 645 0.188360290358117 200 17027233 SGTC_3048 9093155 49.47 µM 0.88273646607212 0.185425386808353 no 646 0.188689337365511 196 25236002 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.882442085047025 0.185507604970407 no 647 0.188768892833053 204 279621 SGTC_207 4185-0010 4.486 µM 0.881854702985919 0.185671723475373 no 648 0.188927692594706 216 3761753 SGTC_3297 9117502 71.43 µM 0.881056837892396 0.185894796594256 no 649 0.189143528592686 181 7453720 SGTC_2315 7733312 200 µM 0.880900085747745 0.185938642062682 no 650 0.189185950537846 202 726316 SGTC_1636 st007707 68.9 µM 0.880235982238331 0.186124470960199 no 651 0.189365742327356 224 403051 SGTC_2716 st080858 38.6235 µM 0.880222785248919 0.186128164897024 no 652 0.189369316194745 213 5296050 SGTC_194 1486-1323 56.904 µM 0.878279452690794 0.186672614265446 no 653 0.189896041809454 225 5178754 SGTC_507 nimesulide 162 µM 0.876913171654957 0.187055984947301 no 654 0.190266900670084 203 4495 A COX2 inhibitor. SGTC_2625 euphol 100 µM 0.876104031942359 0.187283254399269 no 655 0.190486740535316 225 6708538 A triterpene alcohol. SGTC_1322 1348-1070 12 µM 0.875025240329786 0.187586528528473 no 656 0.190780086170459 218 6758089 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.87429049787878 0.18779325581946 no 657 0.190980036363058 204 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2827 7993847 71.43 µM 0.87400280696176 0.187874238914484 no 658 0.19105836254916 191 2985692 SGTC_916 4466-0038 42 nM 0.871872207037318 0.188474659755501 no 659 0.191639048657562 235 5722064 YGL116W CDC20 SGTC_3018 9082602 49.47 µM 0.871573141471332 0.188559033537944 no 660 0.191720644155579 223 17332089 SGTC_997 3996-0078 137 µM 0.869081162054041 0.189262987688959 no 661 0.192401369796941 210 735687 SGTC_1371 2421-0008 32.7 µM 0.868896525194549 0.189315209679206 no 662 0.19245186516627 225 2827552 SGTC_487 nimodipine 119 µM 0.868309877805375 0.189481193661613 no 663 0.192612358056172 197 4497 L-type voltage-gated calcium channels inhibitor SGTC_3334 9142812 21.919 µM 0.868052012119138 0.189554181610964 no 664 0.192682929899335 205 45283678 SGTC_1446 4239-0190 62 µM 0.866672048341966 0.189945069271172 no 665 0.193060862370059 206 1340085 SGTC_978 1416-0512 87.4 µM 0.866012248772988 0.190132138651218 no 666 0.193241722362337 211 6814003 SGTC_3111 9122088 49.47 µM 0.864684006151183 0.190509071255691 no 667 0.19360612513273 203 16876704 SGTC_1048 3161-0300 24.5 µM 0.861451223118047 0.191428395437109 no 668 0.194494787316369 195 2165101 SGTC_630 4356-0227 183 µM 0.860687425336544 0.191645997147891 no 669 0.194705110294471 237 779312 SGTC_3056 9094900 49.47 µM 0.859570991512091 0.191964335323852 no 670 0.195012785630953 232 25236784 SGTC_3214 9129694 49.47 µM 0.858930301540685 0.192147166718375 no 671 0.195189485263802 233 17158655 SGTC_3167 9103034 49.47 µM 0.858220115581264 0.192349954382082 no 672 0.195385465264607 204 5127859 SGTC_2747 doxorubicin 7.63 µM 0.856436876469463 0.192859720004868 no 673 0.195878087228294 167 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1791 st048313 56.1 µM 0.855804649879949 0.193040649424498 no 674 0.196052921400867 195 1204976 SGTC_1934 st074720 32.6 µM 0.854301914132923 0.19347111527921 no 675 0.196468863448191 215 17250992 SGTC_2421 5690543 90.72 µM 0.853224450932038 0.193780119924297 no 676 0.196767423274782 233 3397993 SGTC_1575 cyproterone acetate 48 µM 0.852186457650388 0.194078089386785 no 677 0.197055305872428 228 9880 An androgen receptor antagonist and liver toxin. SGTC_517 1365-0151 113 µM 0.851342232584479 0.194320640878191 no 678 0.197289635627638 212 768657 SGTC_592 k241-0073 46.5 µM 0.850665931857966 0.194515079679602 no 679 0.197477476527347 218 4230158 SGTC_276 colchicine 750 µM 0.848702009041399 0.195080385145122 no 680 0.198023564009336 223 2833 A microtubule depolymerizer. SGTC_2469 5655019 90.81 µM 0.848269429262219 0.195205035174905 no 681 0.198143969390593 221 2788239 SGTC_888 0916-0002 6.97 µM 0.846354986267217 0.195757272387247 no 682 0.198677370893896 199 2802138 YIL048W NEO1 SGTC_506 n9-isopropylolomoucine 153 µM 0.844778189286918 0.196212824132146 no 683 0.199117347189063 214 6610355 SGTC_3253 9135987 49.47 µM 0.844516695407435 0.196288434310193 no 684 0.199190368964686 220 4182430 SGTC_837 0091-0265 12.5 µM 0.843506945500615 0.196580566251317 no 685 0.199472491483426 233 759367 SGTC_2235 salicylic acid 500 µM 0.841382590980766 0.197196025194061 no 686 0.200066817547571 223 338 A COX inhibitor and kinase inhibitor. SGTC_2968 9090663 33.37 µM 0.839324211058511 0.197793480965201 no 687 0.200643700276152 254 25236811 SGTC_650 1328-0195 38 µM 0.839279079771716 0.197806592803703 no 688 0.200656359974222 239 2780821 SGTC_1132 3456-3614 2.5 µM 0.837430065861743 0.198344231898585 no 689 0.201175435806048 205 3125502 SGTC_1221 2958-7315 257 µM 0.836690235466681 0.198559599695215 no 690 0.201383354597161 229 4562705 SGTC_440 fluspirilene 35.1 µM 0.835582155148015 0.198882430343412 no 691 0.201695005586354 228 3396 An atypical antipsychotic. SGTC_3322 9139058 2.11 µM 0.832207509129342 0.199867554556093 no 692 0.202645913038226 212 4908926 YPR165W RHO1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.831927539221669 0.199949414791978 no 693 0.202724923115771 244 6728940 SGTC_1259 0671-0132 43 µM 0.829680806307139 0.200607065460392 no 694 0.20335963807619 218 X1259 SGTC_836 0330-0104 1.35 µM 0.829321378868701 0.200712395356338 no 695 0.203461288300868 222 46494820 SGTC_1686 st019653 115.5 µM 0.828960018654529 0.200818325109418 no 696 0.203563515686183 232 97252 SGTC_968 1309-0633 340 µM 0.828606130145251 0.200922097105092 no 697 0.203663659039331 233 3761976 SGTC_3356 9151811 4.48 µM 0.828097375329315 0.201071337464079 no 698 0.20380767791229 259 1859254 YPR165W RHO1 SGTC_579 4491-1009 110 µM 0.823123747586511 0.20253382233226 no 699 0.205218812765402 270 1271041 SGTC_1234 0326-0494 15.5 µM 0.822717635558349 0.202653518889737 no 700 0.205334292064492 246 1547813 SGTC_2348 9022543 33.42 µM 0.822383690992241 0.202751976638044 no 701 0.205429279220062 247 3162678 YDL140C RPO21 SGTC_1716 st033144 30.6155 µM 0.821759981158088 0.202935943161514 no 702 0.205606757043113 231 674617 SGTC_1615 st002656 86.5 µM 0.821544708686585 0.202999462054545 no 703 0.205668034358364 215 1584458 SGTC_3081 9117243 49.47 µM 0.819886532301935 0.203489125991811 no 704 0.206140397509879 252 45595589 SGTC_31 0508-1974 57.237 µM 0.819190211022648 0.203694961411992 no 705 0.206338949513907 200 6810525 SGTC_1759 st043059 70 µM 0.817810464961689 0.204103186504226 no 706 0.206732710773842 241 669426 SGTC_86 0417-1630 471.922 µM 0.817746314011313 0.204122178676917 no 707 0.206751029423088 243 3634867 SGTC_2199 6590217 200 µM 0.815645967874201 0.204744576695465 no 708 0.207351325232611 209 703109 SGTC_631 k072-0230 41.5 µM 0.815430633408424 0.204808450742496 no 709 0.207412927740387 219 5773147 SGTC_1139 k015-0024 46.9 µM 0.814038955734696 0.205221545818016 no 710 0.207811317294102 241 2766652 SGTC_694 1315-0438 43.2 µM 0.813318204795018 0.205435682518146 no 711 0.208017821067172 229 6793154 SGTC_2586 curcumin 80 µM 0.812837731083313 0.205578506004126 no 712 0.208155549805882 221 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2472 5377652 49.4 µM 0.812605205860291 0.205647646582651 no 713 0.208222222939579 243 1610903 SGTC_1451 4152-0210 104 µM 0.812079275500596 0.205804081079405 no 714 0.208373072086861 233 659563 SGTC_1961 st076550 68.7 µM 0.810263271058276 0.206344782113471 no 715 0.20889444002507 256 1579337 SGTC_1764 st044502 93.5 µM 0.809519394222286 0.206566508411439 no 716 0.209108225904695 222 8407 SGTC_2082 5219693 150 µM 0.807638426918114 0.207127794821072 no 717 0.209649379384683 233 2834649 SGTC_1312 1218-2183 165 µM 0.807492473331659 0.207171385504702 no 718 0.209691404572924 234 6744073 SGTC_110 0850-0284 111.64 µM 0.807262763711347 0.207240001861086 no 719 0.209757556111386 211 3906265 SGTC_2382 9035899 200 µM 0.80569359916629 0.207709084973779 no 720 0.210209770564977 253 6462679 SGTC_1752 st044819 83.042 µM 0.805455066465815 0.207780446373102 no 721 0.210278562937408 232 441209 YML126C ERG13 SGTC_2337 9009472 200 µM 0.805258725180321 0.207839196306687 no 722 0.210335197304814 223 5742383 SGTC_875 0709-0210 25.7 µM 0.804882024382829 0.207951941514169 no 723 0.210443881191033 248 6251364 SGTC_1129 3453-1384 223 µM 0.804366446062946 0.208106310788135 no 724 0.210592686768518 246 1084452 SGTC_2902 5787006 60.46 µM 0.803450785499213 0.208380635322495 no 725 0.210857115734486 241 591003 SGTC_142 0335-0849 62.6745 µM 0.801358344977902 0.209008313689252 no 726 0.211462111365127 228 3889043 YPR107C YTH1 SGTC_570 0987-0065 62.6 µM 0.800776249193182 0.209183125237266 no 727 0.211630595580358 225 3104428 SGTC_108 0509-0257 621.132 µM 0.800685235941374 0.209210465575727 no 728 0.21165694593479 228 536624 SGTC_1570 verbenone 133 µM 0.798533115268506 0.209857574387363 no 729 0.212280591981631 233 29025 A natural terpanoid with antifungal properties. SGTC_971 1315-0384 26.7 µM 0.796488792501774 0.2104733583004 no 730 0.21287399357372 237 6769120 SGTC_50 0929-0078 56.389 µM 0.794279208713629 0.211140112729432 no 731 0.213516452562135 215 1377751 SGTC_773 4358-1457 44.6 µM 0.794277508687366 0.211140626198079 no 732 0.213516947296702 238 1186886 SGTC_2466 5983409 37.09 µM 0.789233349711197 0.212667362110615 no 733 0.214987816729563 227 2879657 SGTC_216 k038-0035 28.382 µM 0.787765463742273 0.213112861059754 no 734 0.215416952909345 246 4444231 YPR107C YTH1 SGTC_1174 0739-0097 51.1 µM 0.785155068049727 0.213906451655249 no 735 0.216181327964602 242 728447 SGTC_934 2950-0684 338 µM 0.784450948295552 0.214120806510041 no 736 0.216387776678993 243 1121253 SGTC_1907 st060210 83.7 µM 0.784413201690327 0.214132301220825 no 737 0.216398847248269 249 688793 SGTC_500 h-89 112 µM 0.782441589210877 0.214733201677523 no 738 0.21697755011753 241 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1671 st016596 74.5 µM 0.782153395710822 0.214821118188727 no 739 0.217062214831252 257 2829167 SGTC_1817 st052116 64.4 µM 0.781482230244795 0.215025945435122 no 740 0.217259462001951 229 4361398 SGTC_3269 9137823 49.47 µM 0.781423964423855 0.215043732430707 no 741 0.217276590483314 203 17682936 SGTC_874 0599-0792 117 µM 0.781412315004313 0.215047288789162 no 742 0.21728001517232 238 765305 SGTC_619 1652-1634 108 µM 0.781055992780735 0.215156084057279 no 743 0.217384781613935 236 5400454 SGTC_766 1391-0721 126 µM 0.779165950616638 0.21573370143144 no 744 0.217940982347843 262 1020919 YIL115C NUP159 SGTC_1472 k841-0093 193 µM 0.776361337530721 0.216592476095926 no 745 0.218767832980672 245 X1472 SGTC_2298 7976326 193.81 µM 0.775224307428368 0.216941198192868 no 746 0.219103563617482 215 2235818 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.774467607850379 0.217173454345378 no 747 0.219327158229446 241 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_190 3970-0790 3.722 µM 0.774248950821061 0.217240594167839 no 748 0.219391792871365 236 2832352 SGTC_152 4469-0003 551.229 µM 0.773869446075375 0.217357151607634 no 749 0.219503999800132 251 697280 SGTC_1137 ixabepilone 100 µM 0.773450591486882 0.217485836491626 no 750 0.219627879429972 242 154225 A novel microtubule stabilizer. SGTC_2097 5376186 200 µM 0.772955100413779 0.217638123207749 no 751 0.21977447674581 233 742755 SGTC_1830 st055982 50.3 µM 0.771626519682429 0.218046759439309 no 752 0.220167831316898 257 455313 An antimicrobial agent. SGTC_3223 9129970 49.47 µM 0.77133626007202 0.218136094439867 no 753 0.220253822556738 259 17248386 SGTC_453 enantio-paf c16 10 µM 0.770549845277727 0.218378240172123 no 754 0.220486899643296 276 13871343 A lipid and platelet activating factor SGTC_1106 tegaserod maleate 11.7 µM 0.768445846950685 0.219026845026331 no 755 0.221111175720974 254 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2825 7998094 58.44 µM 0.767667847697655 0.219266961100991 no 756 0.221342271293804 233 2987815 SGTC_2685 mycophenolic acid 18.85 µM 0.767318922635301 0.219374699939765 no 757 0.22144596024821 237 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1384 3089-0840 101 µM 0.766051231532737 0.219766385379387 no 758 0.221822909636865 220 1069836 SGTC_352 k048-0007 5.11 µM 0.765632163243871 0.219895955437567 no 759 0.221947600627065 271 6811911 SGTC_355 1311-2252 105 µM 0.764350282014644 0.220292567243151 no 760 0.222329264245756 251 5338538 SGTC_1621 st003705 32.4 µM 0.763851473923892 0.220447008368841 no 761 0.222477879060198 240 24207032 SGTC_1913 st060213 96.1 µM 0.763833519845957 0.220452568473121 no 762 0.22248322935177 260 688959 SGTC_1364 1653-0028 37.6 µM 0.763371782811166 0.220595589004741 no 763 0.222620851586053 234 5718652 SGTC_2289 7946404 165.07 µM 0.76307147051839 0.220688637625038 no 764 0.222710386687977 241 1246120 YPR165W RHO1 SGTC_310 1273-0058 1.06 µM 0.762856175450275 0.220755358381291 no 765 0.222774587384857 216 2734232 SGTC_844 0330-0132 15.3 µM 0.762280730246909 0.220933747718444 no 766 0.222946236119185 246 2828079 SGTC_1811 st050069 61.5 µM 0.761708285742638 0.221111288678864 no 767 0.223117064501596 263 3877702 SGTC_1480 1070-0044 41.2 µM 0.761203990867444 0.22126776096667 no 768 0.223267617459775 245 3124987 SGTC_2583 asiatic acid 100 µM 0.75936612894969 0.221838547283212 no 769 0.223816784630178 278 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_529 4076-0302 30.3 µM 0.759049896683445 0.221936844536758 no 770 0.223911354604077 256 5816522 SGTC_990 3985-0011 41.3 µM 0.75857084807182 0.222085798791686 no 771 0.224054658418086 243 5399565 YGL099W LSG1 SGTC_3007 9078383 71.4286 µM 0.757740330232226 0.222344173246559 no 772 0.224303225042342 242 6496995 SGTC_987 1497-1013 404 µM 0.757554802156984 0.222401914532757 no 773 0.224358773334341 249 1676435 SGTC_1377 2944-0135 198 µM 0.755752319090503 0.222963340358262 no 774 0.224898854577306 229 1894137 SGTC_2532 xanthone 78.9 µM 0.755177208320402 0.223142641889717 no 775 0.225071331012949 223 7020 An insecticide. SGTC_2523 spermine 47.74 µM 0.75469237521819 0.223293861424776 no 776 0.225216791270488 218 1103 A DNA binding polyamine. SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.754666170599715 0.223302036311177 no 777 0.225224654730677 266 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_318 1488-0629 67.2 µM 0.754022453097597 0.223502906199544 no 778 0.225417869769124 256 3662576 SGTC_1668 st014914 51.6 µM 0.753187478205472 0.22376361037793 no 779 0.225668631419331 260 2839556 SGTC_651 3253-0966 34.4 µM 0.752631954397732 0.223937157278904 no 780 0.225835555050119 254 781462 SGTC_1102 cgs 12066b 26.1 µM 0.751065715389609 0.224426865485315 no 781 0.226306553863816 236 6438352 A 5-HT1B full agonist. SGTC_3321 9137793 26.8275 µM 0.750764292304068 0.224521179640496 no 782 0.226397261330016 254 4904192 SGTC_2022 5136654 200 µM 0.7494853473332 0.224921606788651 no 783 0.22678236346696 265 1713771 SGTC_164 4100-3994 89.624 µM 0.748758177895099 0.22514945794926 no 784 0.227001485601139 282 4615967 SGTC_1341 1486-1360 280 µM 0.747499898874265 0.225544035637019 no 785 0.227380931913925 272 3976547 SGTC_2803 7707263 71.43 µM 0.747171831456199 0.225646977010953 no 786 0.227479922538787 239 2199229 SGTC_2310 7668677 200 µM 0.745530756739555 0.226162314240191 no 787 0.227975462456605 258 2197143 SGTC_2407 paclitaxel 400 µM 0.745032491914668 0.226318912989195 no 788 0.228126038890997 270 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2012 4023501 200 µM 0.744264419875897 0.226560428893829 no 789 0.228358261010117 273 3477460 SGTC_1252 0493-0875 34.8 µM 0.742320074024414 0.227172467334619 no 790 0.22894671608795 233 3960963 SGTC_1479 0549-0158 134 µM 0.74196977160293 0.227282834028247 no 791 0.229052825289175 239 5440202 SGTC_621 3584-0052 32.1 µM 0.740411146508227 0.227774262412219 no 792 0.229525278697315 265 2273927 SGTC_1520 flindersine 88 µM 0.740048055275474 0.227888829477268 no 793 0.229635417968416 256 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1144 3486-0183 12.5 µM 0.739135126087827 0.228177031455013 no 794 0.229912474593523 271 6744069 SGTC_1092 toremifene 6.32 µM 0.739064819892988 0.228199234863704 no 795 0.229933818942008 267 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1212 0520-0165 585 µM 0.738652336158811 0.228329525872086 no 796 0.230059067751781 274 5403258 SGTC_2976 9009005 19.48 µM 0.737729305951602 0.228621234313302 no 797 0.230339479924912 236 2993148 SGTC_2412 st077135 33.4 µM 0.735567452022637 0.229305271005578 no 798 0.230996988228891 279 13258915 SGTC_1769 st044406 64.4 µM 0.733963276632427 0.2298135921926 no 799 0.231485560045445 277 670903 SGTC_964 1287-0107 19.4 µM 0.733316469189872 0.230018726883115 no 800 0.23168271625601 235 51516812 YPR165W RHO1 SGTC_75 0159-0059 199.013 µM 0.733287913705162 0.230027785603461 no 801 0.231691422534592 277 5377270 SGTC_1780 st038448 24.544 µM 0.732981670216207 0.230124948461576 no 802 0.231784804539009 265 728868 YDL195W SEC31 SGTC_2130 NSC 7 2.4545 µM 0.731009302743579 0.230751277702149 no 803 0.232386735381056 243 21448 SGTC_2709 st078560 56 µM 0.729173831652474 0.23133498956981 no 804 0.23294766812142 285 17250903 SGTC_1906 st060206 94.7 µM 0.725427116934612 0.232529062693376 no 805 0.234095021158049 275 5133468 SGTC_1430 4049-0248 69.1 µM 0.724595135878268 0.232794678210211 no 806 0.234350221925355 270 22774488 SGTC_2738 aclarubicin 5.55 µM 0.724070255012854 0.232962336630296 no 807 0.234511302362258 226 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2249 haloperidol 116.36 µM 0.723672970547911 0.233089282550211 no 808 0.234633265514493 265 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2269 7935389 174.42 µM 0.723289983831199 0.2332116962039 no 809 0.234750872571982 256 97605 SGTC_682 0kpi-0099 17 µM 0.722986054981971 0.233308866061949 no 810 0.234844225832086 281 1714895 YML126C ERG13 SGTC_2126 5251174 33.877 µM 0.722045425916043 0.23360973926853 no 811 0.235133274715938 260 790722 SGTC_2113 5491891 107.031 µM 0.71963697361463 0.234381095811894 no 812 0.235874270514003 266 789979 SGTC_2160 5660466 132.927 µM 0.719608753409901 0.234390142261017 no 813 0.235882960498324 264 2859134 SGTC_365 0121-0052 13.6 µM 0.719062883623273 0.234565167778373 no 814 0.236051087543043 227 3101739 SGTC_2380 9035439 200 µM 0.71877123711206 0.234658709777149 no 815 0.23614094126946 261 6462575 SGTC_1011 4112-3381 17.4 µM 0.718565808619944 0.234724610796746 no 816 0.236204243289842 264 2877139 SGTC_1902 st060212 70.5 µM 0.718122543958533 0.234866844003841 no 817 0.236340865469932 252 688944 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.71778245246703 0.234976003652654 no 818 0.23644571730339 254 3256 An antibiotic and ribosome inhibitor. SGTC_2329 6138490 200 µM 0.715668667125816 0.235655096511721 no 819 0.237097981201655 261 720019 SGTC_2805 7950783 58.44 µM 0.714741137023478 0.235953424174215 no 820 0.237384506740389 260 1178958 YDL195W SEC31 SGTC_913 3487-1245 167 µM 0.714313637725269 0.236090993653252 no 821 0.237516630547567 255 4016153 SGTC_104 0074-0074 590.992 µM 0.713870956737449 0.236233495165441 no 822 0.237653488966246 243 3943124 SGTC_442 cape 100 µM 0.711589013008979 0.236968816656815 no 823 0.238359656292634 253 5281787 SGTC_295 k015-0027 31 µM 0.710315015354963 0.237379889553214 no 824 0.238754405263001 267 3887424 SGTC_167 3672-0051 66.205 µM 0.708479674868051 0.237972775139681 no 825 0.239323714861034 254 3237971 SGTC_2791 5663188 71.43 µM 0.708365258328835 0.238009762945986 no 826 0.239359230598708 271 54690634 SGTC_2220 6782180 200 µM 0.707789349335932 0.238195986759924 no 827 0.23953804070349 249 833803 SGTC_2761 levamisole 97.89 µM 0.707351777136472 0.238337531850012 no 828 0.239673948288307 257 26879 An alkaline phosphatase inhibitor. SGTC_1891 st059073 26.2 µM 0.707001763238022 0.238450786887761 no 829 0.239782691020318 268 688754 SGTC_662 k832-1615 104 µM 0.706819493610307 0.238509776078665 no 830 0.239839329420836 264 5878478 SGTC_1210 3013-0140 750 nM 0.705935753453857 0.238795900305512 no 831 0.240114045975482 261 905973 SGTC_2247 cerulenin 830 nM 0.705890808578719 0.23881045690354 no 832 0.240128021973465 256 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2949 9072542 2.23 µM 0.70361329420695 0.239548725867183 no 833 0.24083681500684 278 16457352 SGTC_502 l-744,832 89.3 µM 0.70331337402292 0.239646039424129 no 834 0.2409302389366 282 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2463 5473429 200 µM 0.69997010554919 0.240732271958663 no 835 0.241972986980593 253 5399405 SGTC_634 1611-4317 11.2 µM 0.699494965763205 0.240886862696568 no 836 0.242121379021752 283 2843522 SGTC_3017 9080681 49.47 µM 0.699443021803685 0.240903766376077 no 837 0.242137604755194 281 16451914 SGTC_3073 9114972 49.47 µM 0.69795513628958 0.241388230100966 no 838 0.242602625720402 240 41905075 SGTC_1722 st034304 3.6505 µM 0.695230136614094 0.242276875682574 no 839 0.243455544431215 277 4036148 YLR033W RSC58 SGTC_3054 9094397 49.47 µM 0.694339923023332 0.242567565663503 no 840 0.243734529915953 274 2598354 SGTC_2553 4-methylesculetin 85.09 µM 0.694237828444797 0.242600915654089 no 841 0.243766536529964 266 5319502 SGTC_2915 7971052 15.16 µM 0.694064349475091 0.242657589606329 no 842 0.243820927327628 247 5741558 SGTC_589 1227-0070 34.1 µM 0.693674634873111 0.242784931845964 no 843 0.243943138284832 260 2841384 SGTC_3089 9117425 49.47 µM 0.692796317413883 0.243072061388042 no 844 0.244218691794324 286 9401657 SGTC_1705 st027868 56.3335 µM 0.692454135147125 0.243183973407727 no 845 0.244326089643014 269 292948 SGTC_1616 st002734 56.1 µM 0.691551933324126 0.24347917546908 no 846 0.24460937808126 259 4026101 SGTC_2959 9079155 11 µM 0.691444730454789 0.243514265304309 no 847 0.244643051188348 280 16189457 SGTC_4 0960-0234 25.671 µM 0.690180691937784 0.24392821857647 no 848 0.245040281950853 260 6821112 SGTC_1392 3455-1037 33.9 µM 0.689072405128676 0.244291477703613 no 849 0.245388852183583 251 981132 SGTC_1755 st041960 45.185 µM 0.688529398451421 0.244469563398889 no 850 0.245559731872623 284 2257073 SGTC_2237 6667747 47.222 µM 0.68834226396867 0.244530952648089 no 851 0.245618636346012 279 729940 YDL015C TSC13 SGTC_3342 9147791 14.508 µM 0.687605982242507 0.244772569601047 no 852 0.245850469994818 268 1838168 SGTC_1602 st001878 87.6 µM 0.686433607799374 0.245157559084858 no 853 0.246219858794504 294 595405 YLR310C CDC25 SGTC_1507 4075-3230 155 µM 0.686162143221893 0.245246750225387 no 854 0.246305433585271 271 659771 SGTC_2127 5253358 187.912 µM 0.685906059323264 0.245330903949703 no 855 0.246386174479526 262 20612 SGTC_3200 9114385 49.47 µM 0.684615612477242 0.245755203809346 no 856 0.246793256240843 250 17018030 YLR208W SEC13 SGTC_2351 9026858 72.31 µM 0.684169563382788 0.245901956649163 no 857 0.246934049684597 291 1409300 SGTC_1054 3429-0080 167 µM 0.6840144400451 0.245953004181739 no 858 0.246983023758809 285 1162877 SGTC_3100 9120536 49.47 µM 0.683934826485001 0.245979205386306 no 859 0.247008160617646 272 16421196 SGTC_2930 9013230 14.89 µM 0.683832108388656 0.246013012617112 no 860 0.24704059443018 259 2995857 SGTC_1060 3448-7350 82 µM 0.683634290535647 0.246078126705046 no 861 0.2471030629405 276 570178 SGTC_446 go6976 132 µM 0.678931063017266 0.247628968869946 no 862 0.248590771280525 284 3501 A protein kinase C inhibitor. SGTC_2684 capsaicin 100 µM 0.678509640413005 0.247768183145983 no 863 0.248724306725186 289 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1494 4358-1428 177 µM 0.675683612450524 0.248702822202681 no 864 0.249620771341654 274 1564571 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.675418036897799 0.248790751180015 no 865 0.249705104605386 298 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_511 blebbistatin 171 µM 0.674831320025899 0.248985064973183 no 866 0.249891469614644 283 3476986 A myosin inhibitor. SGTC_1545 lovastatin 49.4 µM 0.672949329123488 0.249608903035836 no 867 0.25048976392316 266 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1511 0906-3109 28.5 µM 0.672618252362473 0.249718733424555 no 868 0.25059509333603 271 2882180 SGTC_3199 9111318 49.47 µM 0.671233217187223 0.250178478855293 no 869 0.251035985421793 256 8548020 SGTC_202 3594-0513 34.79 µM 0.671162873680937 0.250201840491809 no 870 0.251058388503645 279 708429 SGTC_535 2293-4129 48.2 µM 0.670247344095251 0.250506000617494 no 871 0.251350063879131 299 396118 YIL048W NEO1 SGTC_2799 7812892 81.82 µM 0.669984397162858 0.25059339387913 no 872 0.251433868324967 290 20205235 SGTC_2384 9036245 200 µM 0.669946226812869 0.250606081550814 no 873 0.25144603491585 256 6462766 SGTC_575 k072-0246 11.9 µM 0.669662684264268 0.250700340611658 no 874 0.25153642229584 276 6796779 SGTC_173 1273-0061 2.693 µM 0.667919164737326 0.251280357474985 no 875 0.252092596639229 279 2847414 YPL266W DIM1 SGTC_1832 st054113 55 µM 0.667883273171693 0.251292304975539 no 876 0.25210405268694 272 1251267 SGTC_490 phenamil 164 µM 0.666418659738514 0.251780098156193 no 877 0.252571769414502 276 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2595 hexamethylquercetagetin 100 µM 0.666094689598817 0.251888064709013 no 878 0.252675289311547 295 386331 SGTC_2571 chrysanthemic acid 100 µM 0.665534114993132 0.252074939968834 no 879 0.252854465459654 309 2743 An insecticide. SGTC_604 1000-0114 314 µM 0.665496104456017 0.252087613951856 no 880 0.252866617167215 289 1572745 SGTC_220 paclitaxel 373.376 µM 0.665292368376516 0.252155552097061 no 881 0.252931755431216 270 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_80 0159-0065 512.242 µM 0.665246920136249 0.252170708654181 no 882 0.252946287294681 271 1548079 SGTC_2473 5854593 8.94 µM 0.662181440232966 0.253194125323889 no 883 0.253927473646546 297 2872951 SGTC_1166 k206-0078 225 µM 0.65778868888805 0.254664453062838 no 884 0.255336961806126 273 5404595 SGTC_3075 9116269 49.47 µM 0.657136870325906 0.254883008050336 no 885 0.255546456633296 293 17015205 YNL244C SUI1 SGTC_3261 9137475 49.47 µM 0.656112220608937 0.255226771798467 no 886 0.255875961010645 237 17027690 SGTC_1328 1441-0025 69.2 µM 0.655921503363617 0.255290783023395 no 887 0.255937315868123 285 4562601 SGTC_2277 7947813 106.88 µM 0.655380003513535 0.255472574609849 no 888 0.256111561380291 288 1246798 SGTC_40 0327-0103 19.753 µM 0.654613094055878 0.255730156084659 no 889 0.256358445718441 279 409036 SGTC_815 1582-0027 36.9 µM 0.65457748114559 0.255742120667677 no 890 0.256369913278584 297 3128206 SGTC_1946 st076057 65.1 µM 0.654415054247158 0.255796693632181 no 891 0.256422219055837 286 953009 SGTC_804 1595-0054 20.9 µM 0.654218707272073 0.255862671340719 no 892 0.256485455422076 291 761523 Stimulates phospholipase C. SGTC_700 3453-2283 142 µM 0.652870894576147 0.256315811210215 no 893 0.256919757077932 288 565664 SGTC_3155 9099265 49.47 µM 0.652618452266136 0.256400729782631 no 894 0.257001143333508 288 25236499 SGTC_1350 1495-0454 146 µM 0.652307329666938 0.256505407867049 no 895 0.257101466294967 274 1069057 SGTC_2102 5377816 72.7585 µM 0.650614463093892 0.257075367533623 no 896 0.257647695849193 287 1379702 SGTC_3058 9093861 49.47 µM 0.649973290401787 0.257291411432985 no 897 0.257854737342708 295 17217477 SGTC_1530 rhein 70.4 µM 0.649452521675511 0.257466954498728 no 898 0.258022962628817 290 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2350 9023895 38.85 µM 0.649043135637286 0.257604995855264 no 899 0.258155247625493 292 2997209 SGTC_514 4466-0038 2.65 nM 0.649004322087639 0.257618085435786 no 900 0.258167791280615 267 5722064 SGTC_1624 st003710 6.25 µM 0.645809849120569 0.258696580431883 no 901 0.259201254355477 299 24207033 SGTC_2676 harmalol 100 µM 0.645748584243056 0.258717287057371 no 902 0.259221095400767 281 5459187 A monoamine oxidase inhibitor SGTC_2212 7123476 200 µM 0.644254887636675 0.259222399802592 no 903 0.259705081924685 270 1085715 SGTC_3344 9148862 3.898 µM 0.642644419683296 0.259767570760187 no 904 0.260227426640519 302 4905352 SGTC_2285 7945142 200 µM 0.640236467182643 0.260583806155491 no 905 0.261009438951967 298 2970608 SGTC_2910 7948405 25.97 µM 0.640155242294374 0.260611362353761 no 906 0.261035838788188 276 2971328 SGTC_2207 7258803 200 µM 0.639570493437609 0.26080978737934 no 907 0.261225935255104 302 3666799 SGTC_198 3454-2873 16.191 µM 0.638660053399528 0.261118885057132 no 908 0.261522052454828 287 710957 SGTC_850 0388-0143 75.9 µM 0.637556742661428 0.261493715217325 no 909 0.261881130935366 290 67273 SGTC_3157 9099274 49.47 µM 0.637020950686195 0.261675840592157 no 910 0.262055598509444 275 17217662 SGTC_3299 9121982 43.1275 µM 0.636013055752057 0.262018618597502 no 911 0.262383956256126 293 17594604 YPL160W CDC60 SGTC_2150 5556613 200 µM 0.63217925799525 0.263324566034244 no 912 0.263634874686536 309 743190 SGTC_1519 esterone 74 µM 0.632038921333013 0.263372433393357 no 913 0.26368072237498 299 698 A steroid. SGTC_2379 9035213 200 µM 0.631365955131772 0.263602036801409 no 914 0.263900635499005 281 646551 SGTC_3012 9080433 71.4286 µM 0.628618813166337 0.26454036815555 no 915 0.264799320369853 309 17688859 SGTC_2140 5586273 200 µM 0.628386290923891 0.264619867875706 no 916 0.264875457771422 290 854421 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.628358078911602 0.264629514433685 no 917 0.264884696308242 303 5377381 SGTC_1609 st001574 46.4 µM 0.628343533464527 0.264634488040981 no 918 0.264889459543569 303 3960012 SGTC_2187 6125751 200 µM 0.627327583339925 0.264981995234626 no 919 0.265222263046165 296 874498 SGTC_1167 k781-0610 148 µM 0.626814111387985 0.265157717217708 no 920 0.26539054619036 284 4525169 SGTC_2084 5306078 60.6385 µM 0.625797677252489 0.265505738933847 no 921 0.26572382777747 318 679340 SGTC_2497 7-hydroxyflavone 100 µM 0.625488010753977 0.265611813154085 no 922 0.2658254073937 321 5281894 SGTC_2703 st077852 53.4 µM 0.62497033409346 0.26578918786979 no 923 0.265995264331574 305 6281836 SGTC_1680 diphenhydramine 100 µM 0.622668959375822 0.266578448019619 no 924 0.266751042407597 288 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.621354599661902 0.267029740909164 no 925 0.267183168321092 293 803109 SGTC_2994 9053520 71.4286 µM 0.621312290546421 0.267044274391656 no 926 0.267197084281338 307 4647384 SGTC_1618 st003135 44.5 µM 0.621070173393504 0.267127451040379 no 927 0.267276726465475 312 1270615 SGTC_2999 9069765 71.4286 µM 0.620939127558114 0.267172475830751 no 928 0.267319837769146 273 2097066 SGTC_2794 7785382 27.27 µM 0.620665953839937 0.267266345300525 no 929 0.26740971741353 297 2205081 SGTC_649 1123-0311 367 µM 0.619738776610721 0.267585071142315 no 930 0.26771489098176 295 693629 YIL048W NEO1 SGTC_2971 9092186 9.93 µM 0.619511560002299 0.267663208198727 no 931 0.267789704423818 268 25236400 SGTC_3119 9125183 49.47 µM 0.619501736419855 0.267666586669799 no 932 0.267792939178492 274 22695334 SGTC_1914 st062367 72.6 µM 0.61938425359929 0.267706992364294 no 933 0.267831625990592 310 978205 SGTC_2093 5331342 194.4 µM 0.617734138218506 0.268274838717491 no 934 0.268375302353952 302 33839 SGTC_1397 3532-0190 20.1 µM 0.615462112688532 0.269057690330715 no 935 0.269124791417587 273 5322280 SGTC_166 k072-0058 166.424 µM 0.612744974161334 0.269995413542811 no 936 0.270022489937172 305 5846229 SGTC_2015 5119600 184 µM 0.611940124102502 0.270273492400961 no 937 0.270288686700991 312 2828786 SGTC_2390 9097792 176.6 µM 0.610508394385088 0.270768514321644 no 938 0.270762542214134 288 4497149 SGTC_2629 bisabolol 100 µM 0.610386142204938 0.27081080409517 no 939 0.270803022880823 330 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1176 0848-0131 83.3 µM 0.608849980285347 0.271342477819538 no 940 0.271311940746413 307 6769040 SGTC_2991 9074669 71.4286 µM 0.607537531624319 0.271797134895122 no 941 0.271747121503135 308 17333109 SGTC_1346 1488-2224 62.4 µM 0.607393418242726 0.271847081589813 no 942 0.271794927671505 297 3722427 SGTC_314 1671-0008 2.74 µM 0.606727824929727 0.272077821597065 no 943 0.272015776624863 310 3913060 SGTC_2628 lathosterol 100 µM 0.605998828669694 0.272330653068183 no 944 0.272257765514008 284 6710616 SGTC_1637 st007924 17.4 µM 0.605018153431552 0.272670956206071 no 945 0.272583467408179 289 683336 SGTC_652 0437-0092 114 µM 0.604791725356363 0.272749558764874 no 946 0.272658696184248 287 3091274 SGTC_969 1313-0238 134 µM 0.603710047535269 0.273125208978522 no 947 0.273018216440657 313 5212874 SGTC_3015 9080845 49.47 µM 0.603533170985098 0.273186659889346 no 948 0.273077027738402 296 5296973 SGTC_3277 9138724 49.47 µM 0.600461114362587 0.274255053240369 no 949 0.274099484358907 287 15943418 SGTC_2848 9016370 25.97 µM 0.599171728310106 0.274704087124539 no 950 0.274529186815839 287 7894410 SGTC_1086 cerivastatin 2.18 µM 0.597182426858004 0.275397579729354 no 951 0.275192795257891 283 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2241 6772625 37.8075 µM 0.596862261356558 0.275509273406332 no 952 0.275299672582578 290 2285411 SGTC_2201 6605497 169.863 µM 0.59605693236173 0.275790320811216 no 953 0.275568596984726 291 670741 SGTC_846 0335-0850 148 µM 0.595857293460684 0.275860013495718 no 954 0.275635282599921 297 6819598 SGTC_1938 st074717 56.4 µM 0.594645489603974 0.276283232166754 no 955 0.276040233018708 282 17250979 SGTC_1750 st081859 2.357 µM 0.593541600327889 0.276669039087438 no 956 0.276409375534916 317 5291695 SGTC_2582 agaric acid 100 µM 0.593300569095575 0.2767533140859 no 957 0.276490008994372 286 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_2318 6029776 164 µM 0.59212063590249 0.277166051413449 no 958 0.276884904662952 327 818325 SGTC_893 0958-0369 48.9 µM 0.591806675200915 0.277275924693939 no 959 0.276990026371008 311 6819948 SGTC_222 nsc-310342 10.666 µM 0.590281666756612 0.277809917510906 no 960 0.277500914184991 319 432556 SGTC_1984 st072354 53.1 µM 0.588507075793297 0.278431934883893 no 961 0.278095992935669 309 5762938 SGTC_3237 9133362 49.47 µM 0.587059997140305 0.278939656706369 no 962 0.278581706340457 323 43845137 SGTC_2639 lactacystin 53 µM 0.586562098975214 0.279114453274751 no 963 0.278748921844738 297 3870 A proteasome inhibitor. SGTC_363 0455-0021 3.06 µM 0.586108054875055 0.279273900456615 no 964 0.278901451857271 310 4597466 SGTC_418 lividomycin a 100 µM 0.586058501870684 0.279291304719996 no 965 0.278918100980468 304 72394 An antibiotic. SGTC_1294 1000-1494 117 µM 0.584712516847411 0.279764250041507 no 966 0.279370518153425 300 712797 YDL207W GLE1 SGTC_571 k831-0106 44.2 µM 0.583867575862571 0.280061339462678 no 967 0.27965470467894 331 4783639 SGTC_1900 st060200 72.8 µM 0.583227032801894 0.280286662454071 no 968 0.27987023768888 302 688945 SGTC_2238 6671620 73.2395 µM 0.582999653351626 0.280366668535923 no 969 0.279946766791045 280 729941 SGTC_1627 st003713 25.6 µM 0.581230997008634 0.280989367925589 no 970 0.28054238964045 307 16195070 YER133W GLC7 SGTC_1687 st020778 55.3625 µM 0.581104502213585 0.281033929155953 no 971 0.280585012241396 293 4259299 SGTC_452 diindolylmethane 8 µM 0.580760257768783 0.281155215907093 no 972 0.280701021760483 317 3071 Inhibits expression of several cancer promoting factors. SGTC_1855 st056195 39.6 µM 0.579572633573815 0.281573842403619 no 973 0.281101426142365 309 4028379 SGTC_2932 9016711 44.54 µM 0.578967474608151 0.281787270878618 no 974 0.281305559957543 323 7117328 SGTC_2393 9031399 185.94 µM 0.577962994221302 0.282141704726683 no 975 0.281644551813676 329 1526623 YDL150W RPC53 SGTC_2533 agelasine 13.65 µM 0.576974157762609 0.282490828063669 no 976 0.28197845644565 319 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2950 9072895 21.46 µM 0.576371254895441 0.282703793729199 no 977 0.282182134758754 287 17332245 SGTC_519 k048-0011 62.8 µM 0.575160533299298 0.283131694379813 no 978 0.282591365871729 299 6836379 SGTC_2176 5809774 33.9695 µM 0.574500170348234 0.283365214810392 no 979 0.282814692655672 302 2870539 SGTC_284 0988-0104 32.6 µM 0.573367865718839 0.283765840110251 no 980 0.28319782161167 317 4666532 SGTC_2010 4012422 159 µM 0.573313058806903 0.283785238445816 no 981 0.283216372508604 323 952393 SGTC_1910 st062352 60.4 µM 0.57009250414249 0.284926233568251 no 982 0.284307479469603 313 2245730 SGTC_1554 st069299 38.7 µM 0.569429114900025 0.285161534117982 no 983 0.284532481555992 286 24207999 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.568125780666031 0.285624089194576 no 984 0.284974781643055 326 1273210 SGTC_3227 9130768 49.47 µM 0.56725354407468 0.28593384643044 no 985 0.285270967270169 333 17720899 SGTC_2767 sibutramine 71.45 µM 0.565194866416059 0.286665576854166 no 986 0.28597061401953 321 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3064 1327-0027 10 µM 0.564651298689701 0.286858929067887 no 987 0.286155482882353 304 16000455 YPR107C YTH1 SGTC_2752 diclazuril 33.15 µM 0.561383483305919 0.288022622699812 no 988 0.287268070572886 325 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2878 9043973 25.97 µM 0.561120785901506 0.288116267902589 no 989 0.287357599546619 327 6465167 SGTC_530 4358-1714 28 µM 0.560815803918004 0.288225004542509 no 990 0.287461555933531 313 1564641 SGTC_1058 3448-5425 97.3 µM 0.559686503256168 0.288627807789208 no 991 0.287846644977112 325 7279705 SGTC_492 tmb-8 126 µM 0.558277833794614 0.289130628712843 no 992 0.288327339399225 338 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2034 5197015 53.07 µM 0.557228936032463 0.289505297394198 no 993 0.288685510983573 335 780676 SGTC_2278 7948257 134.34 µM 0.555346305335341 0.290178348683285 no 994 0.289328905949782 312 1247028 SGTC_2215 7188065 200 µM 0.553676496714595 0.290775927663736 no 995 0.289900131556607 320 940217 SGTC_900 1112-0045 141 µM 0.552981357163215 0.291024868674895 no 996 0.290138087994033 307 56211 YIL048W NEO1 SGTC_2396 5342950 42.78 µM 0.552229767858101 0.291294137247669 no 997 0.290395470939112 309 1886677 SGTC_1499 4480-0877 67.3 µM 0.549887134661608 0.292134167238544 no 998 0.291198394463906 318 2861909 SGTC_1370 2001-0092 44.6 µM 0.549676987688388 0.292209577577586 no 999 0.291270471714338 324 790957 SGTC_679 0422-0091 41.4 µM 0.54800977619073 0.29280816995244 no 1000 0.291842595058534 332 627384 YHR062C RPP1 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.547152090495145 0.293116333364367 no 1001 0.29213712383647 309 77254 SGTC_1971 st069429 63.5 µM 0.546834994404419 0.29323030293102 no 1002 0.292246049465773 321 1246522 YGL099W LSG1 SGTC_2309 7664088 163.95 µM 0.546645429060149 0.29329844565329 no 1003 0.292311176050012 329 704922 SGTC_1641 st009299 47.1 µM 0.545883548314265 0.293572391587461 no 1004 0.292572993903424 310 4046054 SGTC_2862 9027634 71.43 µM 0.545178533168595 0.293825996111867 no 1005 0.292815367101683 299 5012562 SGTC_1162 k048-0130 20.1 µM 0.544325825687162 0.294132863132993 no 1006 0.293108639110624 343 6797406 SGTC_739 1486-1183 203 µM 0.541158304249618 0.295274065670816 no 1007 0.29419923703303 321 4346692 SGTC_2863 9028737 58.44 µM 0.539365875316053 0.295920747999637 no 1008 0.294817211248666 333 6460917 SGTC_1663 st014140 55.4 µM 0.537344612869191 0.296650769326838 no 1009 0.295514797197582 326 4207120 SGTC_1967 st070177 51.4 µM 0.532092491490807 0.298551528269915 no 1010 0.297330968759429 343 5729214 SGTC_1644 st010134 20.9 µM 0.53166456517564 0.298706639900867 no 1011 0.29747916911273 326 3818134 SGTC_2891 9063876 19.48 µM 0.530064757480837 0.299286850834099 no 1012 0.298033516451813 319 6472478 SGTC_522 1273-0010 11.6 µM 0.528736390969225 0.299769004864381 no 1013 0.298494164459021 322 5705015 SGTC_1690 st023502 41.2 µM 0.52681499931671 0.300467029451727 no 1014 0.299161032899042 343 24207482 SGTC_2765 myclobutanil 7.74 µM 0.526525404310331 0.300572300391495 no 1015 0.299261602911943 355 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_855 0428-0020 25 µM 0.525773610457154 0.300845663346681 no 1016 0.299522756045181 315 6812414 SGTC_1739 st037196 92.5 µM 0.525739347510423 0.300858124513741 no 1017 0.299534660539816 348 612214 SGTC_559 1550-0661 158 µM 0.524787325559071 0.301204460547626 no 1018 0.299865521671553 329 5830875 SGTC_859 0439-0102 54.6 µM 0.523912508476427 0.301522868472291 no 1019 0.300169697172943 334 610143 SGTC_2828 7998861 71.43 µM 0.52335053573431 0.301727490032316 no 1020 0.300365169695295 283 2988188 SGTC_1883 5-benzylidenerhodanine 20 µM 0.522560466399669 0.302015270053178 no 1021 0.300640078913303 318 1273210 SGTC_1422 4031-0024 15.5 µM 0.521004616421955 0.302582343105102 no 1022 0.30118177773522 346 782427 SGTC_3260 9137109 49.47 µM 0.520753380173409 0.302673957917531 no 1023 0.301269291642857 311 17478346 SGTC_2325 6158266 200 µM 0.519648853091615 0.303076877709368 no 1024 0.301654170785931 311 3623240 SGTC_2969 9091408 28.7 µM 0.519022185136636 0.303305586183003 no 1025 0.30187263529842 330 4286311 SGTC_1148 3909-7663 27.7 µM 0.517605963904978 0.303822733619694 no 1026 0.302366609931017 346 4084526 SGTC_2648 atorvastatin 78.68 µM 0.517172995983421 0.303980914690199 no 1027 0.302517700456726 342 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_923 1900-2434 73.3 µM 0.516632990801776 0.304178252331926 no 1028 0.302706190623666 349 5910570 SGTC_1620 st003704 16.5 µM 0.515811703438473 0.304478490124628 no 1029 0.302992963850999 325 2834414 SGTC_390 dec-rvkr-cmk 16.7 µM 0.512751132423973 0.305598501713706 no 1030 0.304062708523228 325 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2219 9098279 200 µM 0.51174624807959 0.305966635425652 no 1031 0.304414306991407 317 902349 SGTC_42 0133-0086 60.653 µM 0.511464976449641 0.306069712841999 no 1032 0.304512753384764 360 162923 Model of phenazepam hydroxylation. SGTC_882 0843-0131 351 µM 0.511315851529359 0.306124368776754 no 1033 0.304564953553856 333 5425421 SGTC_2406 ethylparaben 405.7 µM 0.510478566813144 0.306431323015214 no 1034 0.30485811329188 311 8434 A possible steroid mimic. SGTC_1468 k284-1086 134 µM 0.510393986562322 0.306462338266618 no 1035 0.304887734472527 329 15996457 SGTC_615 k087-0205 167 µM 0.509457312538058 0.306805905669605 no 1036 0.305215856208054 336 9642773 SGTC_2041 5107442 45.335 µM 0.507343771825545 0.307581765387405 no 1037 0.305956815476946 345 793005 SGTC_1834 st055981 52.8 µM 0.506623344586841 0.30784642409696 no 1038 0.306209562659254 348 471719 YDL150W RPC53 SGTC_2504 purpurogallin 52.29 µM 0.506045979834008 0.308058599055741 no 1039 0.306412185896844 345 5281571 An antioxidant. SGTC_3170 9103054 49.47 µM 0.50576866445933 0.308160532108634 no 1040 0.306509529376421 346 16432970 SGTC_1181 1222-0449 220 µM 0.504632546429033 0.308578290427775 no 1041 0.306908472992837 326 658318 SGTC_2644 guaiazulene 100 µM 0.503856932296111 0.308863631446106 no 1042 0.307180958441871 333 3515 A coloring agent. SGTC_45 0kpi-0036 14.9 µM 0.503830147106954 0.308873487523342 no 1043 0.307190370403574 341 2795021 SGTC_79 0052-0007 94.094 µM 0.501751090058997 0.309638932301444 no 1044 0.307921310754201 330 2801472 SGTC_1379 2144-0755 36.5 µM 0.500912793554212 0.309947801223434 no 1045 0.30821624913302 345 5392327 SGTC_1113 artemisinin 1.17947 µM 0.49643488397859 0.311599947905587 no 1046 0.309793809157802 341 2240 An anti-malaria and mitochondrial poison. SGTC_1691 st019933 84.6 µM 0.495508599287997 0.311942180618456 no 1047 0.310120576715116 371 6176082 SGTC_2849 9019321 12.99 µM 0.493873912336253 0.312546541529322 no 1048 0.310697614795533 337 16489627 SGTC_699 0375-0592 111 µM 0.492389613130714 0.313095739591036 no 1049 0.311221970329405 318 762578 SGTC_2820 7989630 71.43 µM 0.490142172764309 0.31392809316991 no 1050 0.312016648686911 307 2984098 SGTC_1850 st056238 17 µM 0.489895501637913 0.314019507151439 no 1051 0.312103923177124 353 5393177 SGTC_273 hydroxyurea 18.1 mM 0.489466163755458 0.31417864292005 no 1052 0.312255851981024 347 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3345 9148410 3.559 µM 0.488055979887775 0.314701576090626 no 1053 0.312755095049612 349 4903596 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.487198595002524 0.315019698743348 no 1054 0.313058800458888 370 6708760 SGTC_1790 st045711 43.5 µM 0.487083653951261 0.315062356718162 no 1055 0.313099524867302 320 585119 SGTC_1497 4476-2978 41.3 µM 0.486436978226453 0.31530240289612 no 1056 0.313328689031641 357 1528379 SGTC_1795 st049545 62.3 µM 0.486412298858731 0.315311565428713 no 1057 0.313337436152329 309 5291882 SGTC_3001 9076041 71.4286 µM 0.486151075883395 0.315408554780449 no 1058 0.31343002797958 336 16004211 SGTC_1103 duloxetine 36.1 µM 0.486131599292096 0.315415786744227 no 1059 0.313436932028676 342 60835 A selective serotonin reuptake inhibitor. SGTC_1149 3909-7961 23.3 µM 0.48501063691465 0.315832136733657 no 1060 0.313834400110004 337 735261 SGTC_1613 st002381 52.1 µM 0.484190247537114 0.316136995516512 no 1061 0.314125428763876 329 551167 SGTC_1673 st016611 27.3 µM 0.483849042600148 0.316263824971476 no 1062 0.314246503406865 372 5226799 SGTC_1408 3909-7976 48.8 µM 0.481543292642046 0.317121462475611 no 1063 0.315065209178174 341 24152374 SGTC_1734 st037168 69.4 µM 0.481038268452464 0.317309440667961 no 1064 0.315244650342562 329 708907 SGTC_1951 sophoraflavanone G 9.2 µM 0.479960642042287 0.317710708243337 no 1065 0.315627689682619 351 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1702 st027038 51 µM 0.478998315756607 0.318069223471261 no 1066 0.315969913417662 335 5521182 SGTC_2620 irigenin 100 µM 0.478284128167139 0.318335404756388 no 1067 0.316223995760507 371 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2683 piperine 63.03 µM 0.478144461026433 0.318387470370014 no 1068 0.316273694473423 358 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1187 1391-0724 117 µM 0.477833354314131 0.318503458731076 no 1069 0.316384409629926 346 6997986 SGTC_523 1934-0222 13.7 µM 0.477642228304569 0.318574724108578 no 1070 0.316452434795143 390 1361595 SGTC_1021 4476-0760 85.3 µM 0.477626786101282 0.31858048235397 no 1071 0.316457931222666 341 746768 SGTC_60 0986-0278 202 µM 0.477026925279737 0.318804198439116 no 1072 0.316671474316264 372 3110598 SGTC_2402 5553605 200 µM 0.47629072034548 0.319078853869378 no 1073 0.316933637764091 340 6758546 SGTC_2687 chenodiol 100 µM 0.473904863661843 0.319969625753074 no 1074 0.317783875383352 323 5702181 A cholesterol synthesis inhibitor. SGTC_1573 oleylamine 1.06 µM 0.472586750660422 0.320462195957916 no 1075 0.318254018457775 349 5356789 An amine of the fatty acid oleic acid. SGTC_1976 st070609 63.5 µM 0.470601818523591 0.321204548957575 no 1076 0.318962554379581 353 682556 SGTC_181 1447-1644 8.07 µM 0.46948442731215 0.321622761482405 no 1077 0.319361706711933 363 534600 SGTC_205 1486-1330 71.903 µM 0.466350505780756 0.322796917857543 no 1078 0.320482316370475 355 4118834 SGTC_2960 9079389 5.97 µM 0.465817849927585 0.322996659105215 no 1079 0.320672943584889 336 16457355 SGTC_1629 st005085 44.9 µM 0.465706823457908 0.323038299484549 no 1080 0.320712683767319 340 24207091 SGTC_725 1497-0963 19 µM 0.464752046371113 0.323396479289453 no 1081 0.32105451601735 356 3549977 SGTC_812 4251-0442 148 µM 0.463777427022936 0.323762271698391 no 1082 0.3214036087322 383 5723007 SGTC_1828 st055811 49 µM 0.463297998416228 0.323942272511149 no 1083 0.321575390150679 382 5877589 SGTC_2890 9046729 58.44 µM 0.462465989106579 0.324254746982101 no 1084 0.321873593371843 339 903329 SGTC_3105 9121040 49.47 µM 0.462220239257345 0.324347065985828 no 1085 0.321961695354097 323 41448907 SGTC_873 0591-4978 488 µM 0.461757968408686 0.324520753066902 no 1086 0.322127447813267 377 3305145 SGTC_1583 clindamycin 39.6 µM 0.461562082043569 0.324594364144701 no 1087 0.32219769576826 365 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_577 r071-0003 38.6 µM 0.461365596133075 0.324668207406509 no 1088 0.322268165110582 362 4568517 YMR134W ERG29 SGTC_2128 5255449 168.493 µM 0.460834663199855 0.324867776890565 no 1089 0.322458615264905 316 736008 SGTC_940 3232-1287 54.8 µM 0.460438328696672 0.325016785680052 no 1090 0.322600814200296 374 1585493 YIL048W NEO1 SGTC_1991 st073000 8.92 µM 0.460372574926944 0.32504150965148 no 1091 0.322624408187034 371 4301969 YIL048W NEO1 SGTC_182 3448-4371 550.524 µM 0.460049795151611 0.325162888738861 no 1092 0.322740239458574 318 3491403 SGTC_2998 9066762 71.4286 µM 0.459784589915388 0.325262631207772 no 1093 0.322835422668036 381 4945196 SGTC_3287 9117173 37.0625 µM 0.457590284640677 0.326088379101482 no 1094 0.323623412351472 330 2789709 SGTC_2182 6325192 200 µM 0.457238373403749 0.32622088776207 no 1095 0.323749859763242 345 736248 SGTC_2336 9001819 198.65 µM 0.454152930283224 0.327383618495144 no 1096 0.324859379412352 375 2989602 SGTC_3306 9127676 59.7925 µM 0.454105481517283 0.327401512396077 no 1097 0.324876454069329 326 41905287 SGTC_1418 3966-3099 2.4 µM 0.453823517505515 0.327507854976062 no 1098 0.324977927705817 372 740335 SGTC_2374 9071832 200 µM 0.452986960654694 0.327823444294332 no 1099 0.325279065446121 363 17381698 SGTC_305 1682-2595 20.8 µM 0.45091709381822 0.328604825539684 no 1100 0.326024651501962 357 226033 SGTC_16 erodoxin 22.806 µM 0.450146049586168 0.32889608908845 no 1101 0.326302567204697 354 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2144 5628481 200 µM 0.449840898010157 0.329011389442602 no 1102 0.326412582898237 336 2818399 SGTC_3320 9137005 35.139 µM 0.448894195226555 0.329369200964079 no 1103 0.326753991851264 363 4908713 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.448852062653119 0.329385128837318 no 1104 0.32676918947498 359 688751 SGTC_2745 rifampicin 24.3 µM 0.448747683082377 0.329424590010032 no 1105 0.326806841426166 353 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2360 9040895 200 µM 0.448316979865399 0.329587439414372 no 1106 0.326962223969156 335 4914414 SGTC_132 0417-1715 25.805 µM 0.447962759928073 0.329721394620972 no 1107 0.327090036527564 375 6769098 SGTC_2843 9000894 45.46 µM 0.447052152104796 0.330065859035937 no 1108 0.327418702611124 320 2242070 SGTC_2846 9008642 19.48 µM 0.446695835436045 0.330200685628113 no 1109 0.327547344582985 380 2992898 SGTC_1272 0839-0021 27 µM 0.446493418252674 0.330277288048112 no 1110 0.327620432928134 391 5027250 SGTC_629 3448-6466 76.7 µM 0.445135834169153 0.330791233612444 no 1111 0.32811079696844 372 573744 SGTC_2748 diazoxide 86.69 µM 0.444343351381015 0.331091394300817 no 1112 0.328397181544813 346 3019 A potassium channel activatior. SGTC_1073 triclabendazole 3.09 µM 0.442552288123195 0.331770176995362 no 1113 0.329044800891803 347 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3038 9091290 49.47 µM 0.44241799195418 0.331821095273262 no 1114 0.329093380919522 394 25236843 SGTC_992 3909-8734 162 µM 0.442134638026385 0.331928538865118 no 1115 0.329195890272114 363 4288319 SGTC_2398 5228213 48.84 µM 0.438968186649036 0.333130148667465 no 1116 0.330342294033056 377 80771 YMR134W ERG29 SGTC_668 1682-0499 62.6 µM 0.438161395957966 0.333436585491458 no 1117 0.330634645336972 360 682214 SGTC_48 0382-0018 55 µM 0.436974609167801 0.333887555213525 no 1118 0.331064881080247 322 762596 SGTC_2483 5729050 27.16 µM 0.436003064467264 0.334256913330503 no 1119 0.331417253089592 385 2865180 SGTC_883 0850-0245 24.6 µM 0.435500790759055 0.334447928789231 no 1120 0.331599482573545 370 6823229 YPR165W RHO1 SGTC_1196 1588-0294 184 µM 0.434365288311712 0.334879920044669 no 1121 0.332011600099415 372 6144269 SGTC_1126 isoteolin 1.0172 µM 0.434343577131506 0.334888181990936 no 1122 0.332019481904308 350 133323 SGTC_2156 5649887 115 µM 0.434102616171708 0.334979882347678 no 1123 0.332106962897038 363 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1403 3909-7815 62.9 µM 0.433934871250364 0.335043725340641 no 1124 0.332167868174643 363 6615483 SGTC_1031 k035-0009 16 µM 0.432506694360663 0.335587476184427 no 1125 0.332686593903134 383 5180959 SGTC_1284 0929-0043 16 µM 0.432377005386252 0.335636869841493 no 1126 0.332733713904521 368 1239883 SGTC_2616 abietic acid 100 µM 0.431867267602696 0.335831037321801 no 1127 0.332918942947818 366 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1039 k821-0043 94 µM 0.431698222388068 0.335895439096453 no 1128 0.332980379779369 377 15992768 SGTC_976 1348-1067 47.6 µM 0.429472964485463 0.336743652361519 no 1129 0.333789532293638 361 5310671 YGL099W LSG1 SGTC_237 nikkomycin 200 µM 0.429281276089264 0.336816758177727 no 1130 0.333859270632852 370 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3311 9131146 2.8755 µM 0.429134925950439 0.336872577112324 no 1131 0.33391251828065 358 4900406 YPR165W RHO1 SGTC_2566 crystal violet carbinol 226 nM 0.427566706023992 0.337470932134423 no 1132 0.334483305002303 384 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_457 grayanotoxin iii 135 µM 0.424938607163823 0.338474605848678 no 1133 0.335440714851733 354 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1003 4049-0218 100 µM 0.424691292371515 0.338569114860803 no 1134 0.335530866170841 359 295161 SGTC_308 4092-1169 104 µM 0.423896740192894 0.338872814249804 no 1135 0.335820560809394 385 2268590 YDL196W YDL196W SGTC_3139 9095020 49.47 µM 0.423081303671945 0.339184605136305 no 1136 0.336117971371018 342 25236292 SGTC_2347 9049783 174.81 µM 0.422017686266028 0.339591456171313 no 1137 0.336506054052901 382 6467988 YPL169C MEX67 SGTC_730 1436-0052 41.2 µM 0.421444271223944 0.339810874406337 no 1138 0.336715348632752 344 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_138 0850-0259 40.9225 µM 0.42001093176495 0.340359581484949 no 1139 0.337238733891734 359 6813004 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.419731277453376 0.340466677441186 no 1140 0.337340886701868 398 7104 SGTC_123 0083-0120 66.675 µM 0.419336188005486 0.340618002174391 no 1141 0.337485226376666 363 16001701 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.417836254897139 0.341192730769572 no 1142 0.338033420776763 369 229346 A bile salt which induces apoptosis. SGTC_1274 0865-0114 173 µM 0.417597463010428 0.341284262579661 no 1143 0.338120725990523 342 870624 SGTC_2732 terfenadine 20 µM 0.417174485989703 0.341446417690853 no 1144 0.338275392892944 397 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_782 0083-0095 30.5 µM 0.415291241398959 0.342168745049429 no 1145 0.338964356094162 357 3591729 An indicator and reagent. SGTC_2200 6600604 21.907 µM 0.415167705131348 0.34221614819437 no 1146 0.33900956926734 398 2904777 SGTC_229 benomyl 22.8748 µM 0.415127027909126 0.342231757339147 no 1147 0.339024457275746 357 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2030 5175110 200 µM 0.414647660140344 0.342415726308274 no 1148 0.339199926521922 386 2831986 SGTC_2920 7982904 15.77 µM 0.41404513310147 0.342647013663046 no 1149 0.339420526835484 367 6456808 SGTC_1799 st045822 46.1415 µM 0.412716705467476 0.343157155165144 no 1150 0.339907091984016 391 3674992 SGTC_2068 5226020 147 µM 0.412411600486992 0.343274361702604 no 1151 0.340018880941895 361 1810509 SGTC_485 niflumic acid 177 µM 0.412371242033182 0.343289866592633 no 1152 0.340033669133671 383 4488 A COX2 inhibitor. SGTC_2916 7875993 68.79 µM 0.409677508341318 0.344325339024372 no 1153 0.341021265617161 391 1299250 SGTC_1796 st049173 110.4 µM 0.408099831994952 0.344932341426053 no 1154 0.341600191687765 391 94134 SGTC_2649 anisomycin 9.56 µM 0.407769382396087 0.345059530741803 no 1155 0.341721496961178 367 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.406434653191884 0.345573443077129 no 1156 0.342211631089731 360 165521 SGTC_734 2023-0417 80 µM 0.404856064349874 0.346181616478129 no 1157 0.342791657646758 396 3935732 SGTC_2594 a-mangostin 100 µM 0.402933119916851 0.346922993819326 no 1158 0.343498712865877 403 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2045 5106652 78.05 µM 0.401259199239836 0.34756883941922 no 1159 0.344114649796401 381 673349 SGTC_1458 k015-0034 6.33 µM 0.400560996967903 0.347838356408805 no 1160 0.344371683146916 374 3598957 SGTC_3093 9117344 49.47 µM 0.400434414184754 0.347887227580632 no 1161 0.344418290520803 358 24824913 SGTC_1937 st074714 47.2 µM 0.400262953032249 0.347953429455334 no 1162 0.34448142573329 368 17250970 SGTC_3117 9124945 49.47 µM 0.397209451888258 0.349133173704107 no 1163 0.34560650636849 361 17592065 SGTC_717 1532-0246 73.2 µM 0.396239086061787 0.349508388342802 no 1164 0.345964329744669 345 9561992 SGTC_1471 k673-0312 37 µM 0.393663686661395 0.350504939135408 no 1165 0.34691467737352 366 24099884 SGTC_2928 9011484 9.79 µM 0.393552472656417 0.35054799663813 no 1166 0.346955738182924 390 2994751 SGTC_1754 st042065 16.137 µM 0.391520374603725 0.351335079271815 no 1167 0.34770631572112 378 1126236 YIL048W NEO1 SGTC_1286 0929-0070 131 µM 0.391235247173939 0.351445567404018 no 1168 0.347811678493543 361 1420408 SGTC_2670 beta-carotene 100 µM 0.390828593058946 0.351603169378401 no 1169 0.34796196920029 350 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1411 3909-8223 150 µM 0.390642140522107 0.351675439044873 no 1170 0.348030886078493 394 X1411 SGTC_2295 7971645 200 µM 0.390376500368723 0.351778411371848 no 1171 0.348129081077328 401 2978226 YKL099C UTP11 SGTC_988 1497-1057 103 µM 0.390342648467111 0.351791534450524 no 1172 0.348141595306661 403 3533044 SGTC_501 nsc-95397 161 µM 0.389746945706837 0.35202249435276 no 1173 0.348361839257768 399 262093 SGTC_1219 1469-0211 33.1 µM 0.388138048208993 0.352646552641411 no 1174 0.348956938200332 420 6822282 SGTC_894 0960-0238 55.9 µM 0.387647235318786 0.352837007937713 no 1175 0.349138554112365 386 6741907 YDL195W SEC31 SGTC_360 0957-0399 1.01 µM 0.386172172595227 0.353409613892745 no 1176 0.349684580674149 365 6752301 YPR165W RHO1 SGTC_817 1391-0715 46 µM 0.384635221824165 0.354006597375197 no 1177 0.3502538474029 407 1353946 SGTC_2786 7743617 45.45 µM 0.384376513847618 0.354107120252837 no 1178 0.350349702630283 365 583674 SGTC_2813 7971799 71.43 µM 0.384039157583532 0.354238217772157 no 1179 0.350474712559471 381 2234054 SGTC_2690 usnic acid 100 µM 0.383972503831176 0.354264121637577 no 1180 0.350499413530903 400 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2195 6536160 144.242 µM 0.383876623404993 0.354301385143286 no 1181 0.35053494661773 373 3834386 SGTC_2584 androsterone 48.74 µM 0.383860067127948 0.354307819808748 no 1182 0.350541082472044 359 2754130 A steroid. SGTC_1390 3413-2614 145 µM 0.383146489262322 0.354585194299483 no 1183 0.350805575695137 404 3421432 SGTC_1193 1488-0126 41.5 µM 0.381492087999042 0.35522857226126 no 1184 0.351419070501232 365 1384710 SGTC_943 3253-1379 105 µM 0.380652002887597 0.355555430055502 no 1185 0.351730744167694 397 668464 SGTC_2736 butenafine 14.65 µM 0.379692320562457 0.355928950388577 no 1186 0.352086910666958 380 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1744 st037937 38.9 µM 0.379344598516477 0.356064322307699 no 1187 0.352215992655698 354 1016152 SGTC_417 st075190 100 µM 0.378832747657109 0.356263624344789 no 1188 0.352406033807801 419 222757 SGTC_280 3448-3607 3.04 µM 0.378306997339286 0.356468379371417 no 1189 0.352601273950487 383 626179 SGTC_1927 st060202 13.8 µM 0.378249223148859 0.356490882226291 no 1190 0.352622731068789 370 688887 SGTC_2492 derrusnin 100 µM 0.378139231589954 0.356533724953343 no 1191 0.35266358281859 427 1715307 Part of coumarin class of compounds. SGTC_2598 perillyl alcohol 100 µM 0.37758986369707 0.35674773590895 no 1192 0.352867647902035 369 10819 An apoptosis inducer. SGTC_3281 9140613 49.47 µM 0.377015083387835 0.35697169476641 no 1193 0.353081197854269 347 16013766 SGTC_1975 st070967 30.8 µM 0.376839899580696 0.357039963635392 no 1194 0.353146293655376 419 261391 SGTC_2052 5265182 7.135 µM 0.376687912791491 0.35709919636967 no 1195 0.353202773257545 408 1239884 SGTC_2634 4'-methoxyflavone 100 µM 0.374276120021801 0.358039587401668 no 1196 0.354099448299231 378 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1988 st071872 53.4 µM 0.373045239968587 0.358519856997527 no 1197 0.354557386821173 379 16414116 SGTC_179 1273-0063 6.77 µM 0.371880342263008 0.358974587543735 no 1198 0.354990970890293 408 3108139 SGTC_2046 4110841 106 µM 0.370881746310076 0.359364559556722 no 1199 0.355362805715075 401 44119630 YMR134W ERG29 SGTC_1730 st033808 45.1 µM 0.370344529567767 0.359574414261275 no 1200 0.355562899471225 393 1045166 SGTC_1802 st050112 57.9 µM 0.36974280944811 0.35980951641415 no 1201 0.355787065665345 369 4662563 SGTC_639 0833-0042 114 µM 0.368881691766695 0.360146061824021 no 1202 0.356107955171376 406 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2608 thymoquinone 42.66 µM 0.368832189802879 0.360165411674658 no 1203 0.356126404834052 371 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_373 0844-0104 25.9 µM 0.368367679556687 0.360347001794938 no 1204 0.356299546843157 393 5375804 SGTC_1831 st055328 12 µM 0.368076330840733 0.360460914283833 no 1205 0.356408159573999 381 1103068 SGTC_1077 5-fluorocytosine 377 nM 0.368038238658406 0.360475808607598 no 1206 0.356422360930057 408 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2876 9059903 25.97 µM 0.364381371925983 0.36190665311153 no 1207 0.357786621903067 378 6916095 SGTC_1760 st045453 10.4495 µM 0.362311846555229 0.362717266530547 no 1208 0.358559503221559 428 3323419 YIL048W NEO1 SGTC_1509 1326-1131 80 µM 0.362242260599811 0.362744533406343 no 1209 0.358585500760875 377 768313 SGTC_1188 1403-0014 4.57 µM 0.361490322292455 0.363039220686588 no 1210 0.358866469136959 375 9614867 SGTC_816 0325-0417 81.3 µM 0.360220073037892 0.3635372200223 no 1211 0.359341282399435 396 68101 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.360000485494334 0.363623332402284 no 1212 0.359423385250544 395 756377 SGTC_491 tetrandrine 80.3 µM 0.359392806336438 0.363861672802477 no 1213 0.359650627734069 401 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1108 betulinic acid 729.144 nM 0.358640155436702 0.364156946206027 no 1214 0.35993215140629 364 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3205 9113483 49.47 µM 0.357437164116839 0.364629060637908 no 1215 0.360382279445476 440 17018033 SGTC_1941 st076221 61.8 µM 0.356432630811387 0.365023447537932 no 1216 0.360758298007609 363 2828568 SGTC_1781 st038725 66.3 µM 0.356223205802594 0.365105687288052 no 1217 0.360836707295987 366 4270275 YIL048W NEO1 SGTC_1877 wortmannin 25 µM 0.355492477540567 0.365392687787628 no 1218 0.36111033972387 414 312145 A covalent inhibitor of PI 3-kinase. SGTC_3244 9134489 49.47 µM 0.352793250968018 0.366453487257308 no 1219 0.362121721908055 403 16584271 SGTC_710 3448-4187 58 µM 0.352378312628183 0.366616649304524 no 1220 0.36227728214372 382 3946412 SGTC_1158 4092-0494 91.8 µM 0.351612594653613 0.366917808185675 no 1221 0.362564409241815 394 1148199 SGTC_3144 9087057 49.47 µM 0.35079220587309 0.367240560141747 no 1222 0.362872122457012 428 17249618 SGTC_1720 st037298 9.481 µM 0.35072291316417 0.367267825123685 no 1223 0.362898116976428 408 597396 SGTC_470 aa-861 153 µM 0.350162583229967 0.367488325790919 no 1224 0.363108342772799 361 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3016 9080866 49.47 µM 0.35013623479788 0.367498695484812 no 1225 0.363118229250477 407 17066299 SGTC_2764 methyldopa 94.69 µM 0.349788750825195 0.3676354603788 no 1226 0.363248620967976 408 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1698 5-fluorocytosine 1.055 µM 0.349550625739274 0.367729192819885 no 1227 0.363337985433515 402 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_443 clozapine 122 µM 0.348940529913451 0.367969378892125 no 1228 0.363566978391679 423 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_753 1322-0200 289 µM 0.34870843808392 0.368060763714439 no 1229 0.363654104388893 379 5403907 SGTC_330 1488-0319 80.1 µM 0.348295346208174 0.368223434733278 no 1230 0.363809194250896 387 6846614 SGTC_1884 5633444 25 µM 0.346860460972828 0.368788660101637 no 1231 0.364348076099178 377 5724239 SGTC_2226 7298446 200 µM 0.346486969952713 0.368935831102344 no 1232 0.364488387478507 415 3283010 SGTC_1085 doxorubicin 7.67 µM 0.345738091694438 0.369230978174061 no 1233 0.364769777289433 414 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2689 tacrolimus 100 µM 0.345387271198782 0.369369269691548 no 1234 0.364901622602294 410 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_628 1636-0253 16 µM 0.344244979176183 0.369819671997929 no 1235 0.365331029267681 396 4456143 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.34386536651009 0.369969391709008 no 1236 0.365473769427564 434 688667 SGTC_1281 0884-0031 11.8 µM 0.343154707726034 0.370249729394092 no 1237 0.365741038063619 384 1548255 SGTC_1321 1326-2144 215 µM 0.342691033043086 0.370432675002413 no 1238 0.365915454648434 420 3513030 SGTC_1199 1638-0010 4.46 µM 0.342352474068658 0.370566273977705 no 1239 0.366042825024196 392 3111136 SGTC_2275 7947463 200 µM 0.341960060760369 0.370721143978501 no 1240 0.366190474587078 390 1225414 SGTC_2416 tofa 880 nM 0.340846874588851 0.37116058842709 no 1241 0.366609430152257 356 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_542 3381-0244 89.3 µM 0.340488839568844 0.371301963063801 no 1242 0.366744213003019 440 1112843 SGTC_2693 st077581 40.7 µM 0.339104735238219 0.371848657270102 no 1243 0.367265415681634 418 25238761 SGTC_1447 4239-0816 81.9 µM 0.338217160183979 0.372199368207698 no 1244 0.367599772554742 376 1341554 SGTC_3259 9138485 49.47 µM 0.335837192193446 0.373140296727854 no 1245 0.368496821042498 372 17646153 SGTC_2248 tofa 1.1 µM 0.334766474499046 0.373563855920191 no 1246 0.368900626091578 403 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2606 farnesol 9.78 µM 0.333459773103653 0.374080973538006 no 1247 0.369393624938783 391 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1863 st057641 20.1 µM 0.330832358631749 0.375121439076182 no 1248 0.370385558625958 418 3921635 SGTC_2847 9005661 71.43 µM 0.32930826428772 0.375725403139497 no 1249 0.370961349089053 405 2991449 SGTC_2184 6075246 200 µM 0.327020758681039 0.376632461122748 no 1250 0.371826092256937 398 2267320 SGTC_2630 antimycin a 100 µM 0.326450553528626 0.376858669233704 no 1251 0.372041747184532 394 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1656 st012921 11 µM 0.325238743533023 0.377339550997007 no 1252 0.372500194064862 413 6732821 SGTC_312 4092-0653 6.84 µM 0.324585618502921 0.377598809124792 no 1253 0.372747356578309 393 1148278 SGTC_3164 9100705 49.47 µM 0.324505361208133 0.377630671083769 no 1254 0.37277773201377 415 17174235 SGTC_1887 st057648 70.8 µM 0.323070296801607 0.378200528679681 no 1255 0.373321002386854 418 688672 SGTC_1952 st077036 64.1 µM 0.322639719451297 0.378371560753124 no 1256 0.373484054647191 397 2937007 SGTC_2796 7949634 45.45 µM 0.322416874495716 0.378460087623908 no 1257 0.373568451108826 390 2971588 SGTC_1142 3253-1408 9.78 µM 0.322016336715224 0.378619220369297 no 1258 0.373720159133871 422 256655 SGTC_1402 3909-7673 35.9 µM 0.318556208644379 0.379994775639478 no 1259 0.375031532519428 403 5328014 SGTC_995 3931-2021 34.6 µM 0.318124261008116 0.380166601135849 no 1260 0.375195340612066 403 730143 SGTC_121 0557-0495 61.343 µM 0.316471501281069 0.380824274555472 no 1261 0.375822326556565 443 3104427 SGTC_3187 9109394 49.47 µM 0.315542001391648 0.381194296713942 no 1262 0.376175083046663 394 17098090 SGTC_374 0880-0231 82.3 µM 0.315058328894476 0.381386883620048 no 1263 0.376358683579417 418 6833587 SGTC_526 4469-0568 170 µM 0.314841409104593 0.381473265474614 no 1264 0.376441034728351 400 2901964 SGTC_195 4234-0266 16.654 µM 0.312670409269784 0.382338126173058 no 1265 0.377265539556849 408 2303354 SGTC_2087 5276107 200 µM 0.312122278927627 0.382556577758835 no 1266 0.377473797792439 399 144405 SGTC_1068 loratadine 26.9 µM 0.311617819862112 0.382757657646291 no 1267 0.377665494924839 408 3957 A H1 histamine antagonist. SGTC_389 tpck 16.7 µM 0.311276803737391 0.382893606274611 no 1268 0.377795099943984 379 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_306 1672-3436 11.6 µM 0.309975598858037 0.383412473753542 no 1269 0.378289756170331 428 6797378 SGTC_1153 4055-0057 267 µM 0.309182171640236 0.383728962917857 no 1270 0.378591477461019 402 882706 SGTC_2666 tannic acid 100 µM 0.30880542647783 0.383879269489113 no 1271 0.378734770516838 397 16134267 A thiamine antagonist. SGTC_2125 5246583 200 µM 0.308803011973307 0.383880232838262 no 1272 0.378735688914815 437 835267 SGTC_1773 st048542 73.5835 µM 0.307573061391267 0.384371056844198 no 1273 0.37920361050855 391 3237138 SGTC_1428 4049-0204 61.7 µM 0.306298171925305 0.38488000989937 no 1274 0.379688815483073 417 X1428 SGTC_671 0560-0003 407 µM 0.305579034865148 0.385167186694587 no 1275 0.37996259256301 433 3238678 SGTC_2186 6124449 200 µM 0.304878328109837 0.385447064210649 no 1276 0.380229411062585 425 3834182 YLR033W RSC58 SGTC_938 3126-1755 342 µM 0.304626024289426 0.385547854460481 no 1277 0.380325498493703 431 1777771 SGTC_2519 cryptotanshinone 88.04 µM 0.303889022523354 0.385842315933641 no 1278 0.380606220650537 389 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_912 3474-0017 2.18 µM 0.303717777437405 0.385910744571498 no 1279 0.380671456489438 427 3360550 SGTC_1038 k292-0204 154 µM 0.301753342489965 0.386695975916435 no 1280 0.38142005053063 382 4454212 SGTC_551 k048-0028 34.9 µM 0.301644289644623 0.386739580557215 no 1281 0.381461620705626 409 6836383 SGTC_2844 9010103 25.97 µM 0.301226456259537 0.386906663931952 no 1282 0.38162090849639 422 2480525 SGTC_2099 5377090 177.372 µM 0.301114451180796 0.386951456129698 no 1283 0.381663610842441 410 2243829 SGTC_2751 anetholtrithion 17.25 µM 0.300966814602034 0.387010500099328 no 1284 0.381719900028506 417 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_805 3852-0218 479 µM 0.300637193050663 0.38714233434939 no 1285 0.381845583387766 427 6615355 SGTC_3190 9110366 49.47 µM 0.298016411019326 0.388190994996241 no 1286 0.38284531912021 434 17123768 SGTC_1338 1486-1223 76 µM 0.296417684735743 0.388831098779761 no 1287 0.383455560693992 436 3444526 SGTC_1179 1021-1431 9.29 µM 0.295514047804641 0.389193033855808 no 1288 0.38380061133562 434 2840958 SGTC_2137 5261020 140 µM 0.295417660895224 0.389231645532528 no 1289 0.383837421787704 409 763655 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.295346507859581 0.389260149461814 no 1290 0.383864596019606 388 16623 A steroid. SGTC_201 4262-0159 12.803 µM 0.294829126246214 0.389467430615857 no 1291 0.384062207677152 434 1341029 SGTC_1779 st039427 55 µM 0.293124695557068 0.390150507280334 no 1292 0.384713420542876 428 1124498 SGTC_387 norethindrone acetate 66.7 µM 0.292349265079114 0.390461385331097 no 1293 0.385009797546451 422 541197 SGTC_562 3772-2733 112 µM 0.291961833605842 0.390616736845745 no 1294 0.385157902774071 445 2876874 YIL048W NEO1 SGTC_819 1013-0258 27.7 µM 0.290898827694563 0.391043068493903 no 1295 0.385564348963203 407 5753198 SGTC_503 tyrphostin 8 294 µM 0.29046658956013 0.391216460418965 no 1296 0.385729653576753 449 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3232 9132874 49.47 µM 0.289575151520549 0.391574128203246 no 1297 0.386070639541512 414 3784940 SGTC_2880 9042983 58.44 µM 0.287366143820516 0.392460833178227 no 1298 0.386915990868286 421 6464714 SGTC_262 fenpropimorph 62.5 µM 0.287165016374249 0.392541594392523 no 1299 0.386992985790673 425 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_13 0199-0087 65 µM 0.286505951277709 0.39280626943768 no 1300 0.387245317988115 407 4589825 SGTC_2340 7987427 183.45 µM 0.286422942380651 0.392839608635821 no 1301 0.387277102474538 399 2239331 SGTC_1825 st052143 62.6 µM 0.28624031598255 0.39291296037988 no 1302 0.387347033617797 426 674173 SGTC_601 0986-0029 62.9 µM 0.285715676040807 0.393123702730972 no 1303 0.387547948621449 419 24747981 SGTC_2743 auranofin 4.32 µM 0.285182057475723 0.393338083834456 no 1304 0.387752332956002 426 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_549 1661-1316 519 µM 0.284059453971847 0.393789194990904 no 1305 0.388182409307678 430 2857282 SGTC_729 4092-0585 94.1 µM 0.283775078879483 0.393903491988873 no 1306 0.388291376960067 390 2169061 SGTC_1024 4507-0395 26 µM 0.282614103747536 0.394370209760875 no 1307 0.388736333844617 393 4201836 SGTC_1 0258-0098 57.368 µM 0.281607920827274 0.394774823024691 no 1308 0.389122082991538 388 6790032 YDR047W HEM12 SGTC_1043 0916-0009 19.3 µM 0.281580494999541 0.394785853280297 no 1309 0.389132599003088 439 3101130 SGTC_663 1486-0733 13.9 µM 0.279369260983829 0.395675455145562 no 1310 0.38998072925023 419 722445 YPR165W RHO1 SGTC_1958 st076513 41.9 µM 0.278885188391278 0.395870275168871 no 1311 0.390166467854909 435 732122 YGL099W LSG1 SGTC_3067 9117431 49.47 µM 0.276371928923824 0.396882179584403 no 1312 0.391131207433234 434 17150885 SGTC_2923 7992654 58.14 µM 0.27612826837985 0.396980320782512 no 1313 0.391224774685138 429 2985126 SGTC_2922 7999257 32.47 µM 0.275793893863416 0.397115010226404 no 1314 0.391353186945813 428 2988377 SGTC_1059 3448-6867 171 µM 0.275705859100864 0.397150473562376 no 1315 0.391386997541485 430 3934407 SGTC_1814 st052110 31.539 µM 0.275631946026274 0.397180248868571 no 1316 0.391415385201087 431 674163 SGTC_65 0798-0905 34.986 µM 0.275553020223706 0.397212044174787 no 1317 0.391445698728475 444 3602145 SGTC_3149 9097855 49.47 µM 0.275386093171409 0.397279293086457 no 1318 0.391509813618574 454 25236625 YMR079W SEC14 SGTC_929 2805-0021 398 µM 0.275368650000829 0.397286320489409 no 1319 0.391516513523389 423 3098024 SGTC_2544 sphondin 68.51 µM 0.273066160429416 0.398214225925091 no 1320 0.392401179289908 394 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1567 st069303 68.4 µM 0.272680744170988 0.398369605445364 no 1321 0.392549318944585 442 5581319 SGTC_821 1114-0266 29.2 µM 0.272620262582859 0.398393989897161 no 1322 0.39257256722825 432 3123235 SGTC_1561 5-methoxyflavone 52.9 µM 0.270694222941983 0.399170721160875 no 1323 0.393313110204615 450 94525 SGTC_751 0833-0568 350 µM 0.270029308148752 0.399438960198257 no 1324 0.393568853096071 440 6954252 SGTC_1815 st051655 58.2 µM 0.269553903665235 0.399630776356298 no 1325 0.393751733734073 419 5984156 SGTC_53 0973-0023 39.979 µM 0.267705976016598 0.400376607749494 no 1326 0.394462824735774 435 674768 SGTC_1625 st003711 30.1 µM 0.267313491421048 0.400535063071387 no 1327 0.394613899980397 423 24207034 YER133W GLC7 SGTC_345 1362-0200 395 µM 0.266130045294963 0.401012947286358 no 1328 0.395069528154314 403 1419823 SGTC_2049 5262831 67.185 µM 0.265760325807399 0.401162273128654 no 1329 0.395211900049897 420 763417 SGTC_3340 9146634 11.102 µM 0.264413283952853 0.401706451258753 no 1330 0.395730738279263 443 4907387 SGTC_1228 0124-0032 52.5 µM 0.264285082590055 0.401758252012914 no 1331 0.395780127065318 423 X1228 SGTC_2502 avocadyne acetate 18.59 µM 0.263679395740055 0.402003007805426 no 1332 0.396013486813068 385 3952079 SGTC_683 panaxydol 45 µM 0.262645573868982 0.402420860101637 no 1333 0.396411884988986 416 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_839 0122-0028 230 µM 0.262010612802607 0.402677555310662 no 1334 0.396656630054798 441 759448 SGTC_3289 9119912 71.43 µM 0.261753983516796 0.40278131454264 no 1335 0.396755559099311 424 17014829 SGTC_3204 9114183 49.47 µM 0.260720334291015 0.403199304346238 no 1336 0.39715409188045 390 17027248 SGTC_2381 9035592 200 µM 0.260292294330337 0.403372428694274 no 1337 0.397319158021277 424 4749657 SGTC_1067 clotrimazole 1.36 µM 0.259898256494086 0.403531817340937 no 1338 0.397471128095355 411 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1821 st053465 65.6 µM 0.259813637683823 0.403566047814036 no 1339 0.397503765385213 401 675086 SGTC_93 0109-0045 59.227 µM 0.257877036399366 0.404349653982661 no 1340 0.398250903953148 443 88733 SGTC_1531 st059297 52.4 µM 0.256635506790983 0.404852215731202 no 1341 0.398730081152839 420 7566702 SGTC_1082 camptothecin 424.86 nM 0.255202155408863 0.405432620669341 no 1342 0.3992834832007 486 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3210 9128157 49.47 µM 0.254834624872523 0.405581477844042 no 1343 0.399425415571072 408 17590849 SGTC_623 k072-0108 16.9 µM 0.253180968464533 0.40625141022177 no 1344 0.400064186240285 442 5382803 SGTC_2845 9003024 42.97 µM 0.252910415807662 0.406361043206585 no 1345 0.400168720216216 411 2990173 SGTC_3132 9126706 49.47 µM 0.25273980459542 0.406430181828234 no 1346 0.400234643292589 461 850858 SGTC_3135 9127742 49.47 µM 0.251384813947818 0.406979382722436 no 1347 0.400758303765803 426 3643468 SGTC_2834 9001755 58.44 µM 0.25092351703074 0.407166396057273 no 1348 0.40093662099641 444 2989575 SGTC_1751 st044839 27.194 µM 0.250847207827714 0.407197334439202 no 1349 0.400966120790443 422 5291326 SGTC_1279 0874-0590 65.2 µM 0.250450685873552 0.407358107427963 no 1350 0.401119418282005 432 3523074 SGTC_2358 9037157 4 µM 0.249745686546704 0.407643993555195 no 1351 0.401392012346132 435 2388925 SGTC_1525 8-methoxypsoralen 92.5 µM 0.248283814286034 0.408236957802082 no 1352 0.401957410666071 468 4114 Related to psoralen; DNA damaging agent. SGTC_955 1216-0110 33 µM 0.248195365951671 0.40827284094941 no 1353 0.401991625818809 428 3619719 SGTC_618 k072-0232 33.2 µM 0.247336407484369 0.408621357042241 no 1354 0.402323942389704 446 5872756 YGL099W LSG1 SGTC_3265 9137266 49.47 µM 0.247198338734693 0.408677384173592 no 1355 0.402377365457629 424 17224265 SGTC_2461 5755302 26.15 µM 0.246748007654271 0.408860137684291 no 1356 0.402551625142992 458 2788904 SGTC_3152 9099253 49.47 µM 0.246334980499969 0.409027769926496 no 1357 0.402711466762305 443 25236131 SGTC_867 0518-0118 155 µM 0.246331370459628 0.40902923517997 no 1358 0.402712863920617 456 6848158 SGTC_1973 st070275 50.2 µM 0.246171651942491 0.409094063459424 no 1359 0.402774679446478 442 17118334 SGTC_2713 st079149 53.4 µM 0.245877972830641 0.409213271602466 no 1360 0.402888347805156 434 3103253 SGTC_423 5-fluorouracil 457 µM 0.245700159396907 0.409285452452433 no 1361 0.402957174398993 410 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1874 staurosporine 7.6 µM 0.244418561833705 0.409805789695437 no 1362 0.40345333369293 459 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_654 1124-0271 80.9 µM 0.244160088686806 0.409910750816863 no 1363 0.4035534181735 442 5403748 SGTC_2043 5101342 149 µM 0.241848747593125 0.410849629425953 no 1364 0.404448682381176 427 678451 SGTC_2308 7584454 197.62 µM 0.24126046234249 0.411088675706043 no 1365 0.404676626177227 439 893577 SGTC_1084 voriconazole 435 nM 0.240914258996109 0.411229368855695 no 1366 0.404810785250932 471 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2429 5902844 64.44 µM 0.237940322547459 0.412438411704901 no 1367 0.405963690297413 450 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2517 totarol 10 µM 0.23698510691505 0.412826928035603 no 1368 0.406334172078091 413 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_468 gf-109203x 121 µM 0.235444192911785 0.413453846233748 no 1369 0.406931994478722 439 2396 A protein kinase C inhibitor. SGTC_1709 st033179 39.1045 µM 0.234751217303656 0.413735854203959 no 1370 0.407200916319723 440 573381 SGTC_63 0099-0242 26.702 µM 0.23385362993156 0.41410119551376 no 1371 0.407549306510096 437 3898502 YLR359W ADE13 SGTC_424 splitomicin 100 mM 0.232206730104374 0.414771719537347 no 1372 0.408188725371295 443 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3272 9137413 49.47 µM 0.232117841151684 0.414807917150189 no 1373 0.408223244018307 430 17614870 SGTC_1460 k062-0059 9.15 µM 0.23105845730568 0.4152393780605 no 1374 0.408634694068423 408 1373085 SGTC_372 0155-0182 15.9 µM 0.229963691641873 0.415685356525374 no 1375 0.409059991751912 434 771486 SGTC_1936 st074407 74.3 µM 0.228994094715518 0.416080435294501 no 1376 0.409436752962753 415 809813 SGTC_723 4182-0001 115 µM 0.228755166438165 0.416177803728281 no 1377 0.409529607400218 453 744821 YLR208W SEC13 SGTC_264 promethazine 12.5 mM 0.228750574670463 0.416179675023205 no 1378 0.409531391943645 460 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3108 9121785 49.47 µM 0.227180820642232 0.416819512010808 no 1379 0.410141570363494 456 17140271 SGTC_3130 9127414 49.47 µM 0.226488953894615 0.417101589291083 no 1380 0.410410574778106 442 1494646 SGTC_1578 josamycin 24.2 µM 0.226087400385884 0.417265324100193 no 1381 0.410566721968009 418 5282165 A P450 substrate. SGTC_1303 1160-0052 261 µM 0.225922448029815 0.417332588143803 no 1382 0.41063086907766 463 3562476 SGTC_1195 1502-0147 41.1 µM 0.224484845087853 0.417918914099807 no 1383 0.411190028948015 442 817940 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.221763946805535 0.419029130243953 no 1384 0.412248823453829 430 688801 SGTC_858 0438-0351 2.77 µM 0.221363590239786 0.419192543567721 no 1385 0.412404669988835 433 2799119 SGTC_672 1441-0018 53.7 µM 0.220975636775955 0.41935090762373 no 1386 0.412555701553987 416 251141 SGTC_1241 0364-0022 50.8 µM 0.220738695543509 0.419447634349759 no 1387 0.412647949928902 451 4563895 SGTC_401 neomycin 50 µM 0.219135846379128 0.420102094420079 no 1388 0.413272113967192 417 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_233 rapamycin 362 pM 0.218422876902326 0.420393278430929 no 1389 0.413549821314604 426 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2453 5731132 22.18 µM 0.217186709482922 0.420898244996519 no 1390 0.414031420895429 448 1362040 SGTC_1164 k060-0068 93.7 µM 0.216021159681342 0.421374483959828 no 1391 0.414485626953724 430 5963676 SGTC_3114 9122766 49.47 µM 0.21579099571585 0.42146854165506 no 1392 0.41457533367491 414 17176985 SGTC_1307 1187-1599 12.2 µM 0.215317737468633 0.421661955160334 no 1393 0.414759800720368 445 1538471 SGTC_2539 epi(13)torulosol 80 µM 0.215039102686758 0.421775837834323 no 1394 0.4148684160426 434 6708597 SGTC_2623 humulene 100 µM 0.212153039694736 0.422955802952184 no 1395 0.415993820829626 420 6187145 An anti-inflammatory. SGTC_2730 imipramine 71.33 µM 0.209906004987027 0.423874981106079 no 1396 0.416870517669871 422 3696 A tricyclic antidepressant. SGTC_606 k015-0008 38.6 µM 0.208695642495762 0.42437026730827 no 1397 0.417342921014465 450 1970475 SGTC_3329 9141233 27.5565 µM 0.207970214269319 0.424667173360203 no 1398 0.417626112211932 466 4909101 YNL103W MET4 SGTC_3160 9100216 49.47 µM 0.206591710001747 0.425231490543009 no 1399 0.418164367531165 471 17191039 SGTC_1889 st059080 5.18 µM 0.206063875568541 0.425447610331157 no 1400 0.418370508147132 432 176925 Isolated from Daphnopsis sellowiana. SGTC_2860 9025725 38.96 µM 0.205922532270129 0.425505486608955 no 1401 0.41842571220914 476 40546248 SGTC_298 1391-0729 10 µM 0.205381221179604 0.425727153771148 no 1402 0.418637145438915 443 3237558 SGTC_183 3914-0051 30.55 µM 0.20461549425599 0.426040759403781 no 1403 0.418936274430293 463 1596232 SGTC_2724 maprotiline 69.64 µM 0.204371364930416 0.426140753105336 no 1404 0.419031652701822 464 4011 A tricyclic antidepressant. SGTC_1134 3477-0009 42.5 µM 0.203338999996281 0.426563655145576 no 1405 0.419435037305502 466 3973534 SGTC_1157 4092-0394 27.6 µM 0.203133542565559 0.426647829627661 no 1406 0.419515327526833 427 3659885 SGTC_3043 9092303 49.47 µM 0.201946382174023 0.427134266299605 no 1407 0.419979320636024 424 25236084 SGTC_2798 7813637 45.45 µM 0.201792777623203 0.427197213579254 no 1408 0.420039364012976 477 956368 SGTC_612 0302-0167 22.4 µM 0.201592713445317 0.427279202834091 no 1409 0.420117571054448 447 235821 SGTC_1296 1068-0102 11.9 µM 0.20109756031362 0.427482137400801 no 1410 0.420311144808282 465 767053 SGTC_105 0111-0055 734.78 µM 0.199857840897921 0.427990310576838 no 1411 0.420795881629234 437 5179370 SGTC_2370 9071495 200 µM 0.199799406832419 0.428014266229317 no 1412 0.420818732626498 457 21791103 SGTC_96 0929-0093 37.281 µM 0.19747961650914 0.428965501827043 no 1413 0.42172611551225 411 6991579 SGTC_2180 6301957 200 µM 0.19679742406869 0.429245315256122 no 1414 0.42199303349723 457 845462 SGTC_803 4488-1585 147 µM 0.196374417910795 0.429418836664661 no 1415 0.422158558984414 470 747204 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.195980679427519 0.429580364433006 no 1416 0.422312644167464 447 521171 SGTC_737 1950-0117 57.9 µM 0.19551496698943 0.429771434104239 no 1417 0.422494910906086 441 5393513 SGTC_704 1310-0270 142 µM 0.193305359106189 0.430678202046388 no 1418 0.423359914762908 465 5718033 SGTC_1492 4158-0558 28.5 µM 0.193249150737178 0.430701273347197 no 1419 0.423381923710483 478 3967268 SGTC_2739 tacrine 100.86 µM 0.193136353195386 0.430747572967127 no 1420 0.423426091434337 465 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1689 st020265 53.493 µM 0.19139446673908 0.431462679593105 no 1421 0.424108277419594 469 5758320 YPR016C TIF6 SGTC_785 1270-0111 65.3 µM 0.191080429215483 0.431591627190838 no 1422 0.424231290176263 436 6741994 SGTC_986 1493-0483 84 µM 0.189224794865355 0.432353721411496 no 1423 0.424958317604564 470 40079 SGTC_1868 st057644 42.7 µM 0.188874445691343 0.432497635359719 no 1424 0.425095611229438 424 688665 SGTC_450 aminopyrene 156 nM 0.188507980487905 0.43264817891893 no 1425 0.425239230069814 471 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1353 1498-1206 8.11 µM 0.18791394866889 0.432892227388507 no 1426 0.42547205403512 466 6756808 SGTC_1552 6-methylflavone 10.6 µM 0.185932668107219 0.433706389370228 no 1427 0.426248781713216 484 689013 SGTC_851 0394-0702 453 µM 0.185439909178802 0.433908921218626 no 1428 0.42644200410674 452 762646 SGTC_1948 st076329 66.6 µM 0.184027313559702 0.434489616741593 no 1429 0.426996013858237 482 24208413 SGTC_1305 1181-0477 144 µM 0.183335330210841 0.434774131722649 no 1430 0.427267457334326 446 6252086 SGTC_3209 9113616 49.47 µM 0.182525918155143 0.435106971394728 no 1431 0.427585008120096 470 16649353 SGTC_1143 3454-2408 5.08 µM 0.18215565923354 0.435259241522717 no 1432 0.427730284780703 458 X1143 SGTC_2905 7799065 20.05 µM 0.181195420414981 0.435654187391139 no 1433 0.428107094543308 466 1296806 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.181132907098409 0.435679901324477 no 1434 0.428131627830069 451 6708739 YPR165W RHO1 SGTC_2131 toluylene red 5.2905 µM 0.180617146607321 0.435892062183725 no 1435 0.428334048096213 433 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_474 dl-dihydrosphingosine 5 µM 0.179963926407546 0.436160794309029 no 1436 0.428590444165816 434 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1168 k815-0004 80.5 µM 0.17953647492018 0.436336662068357 no 1437 0.428758239870219 463 642433 SGTC_1467 k284-1082 293 µM 0.178810299495448 0.436635463627316 no 1438 0.429043328898576 455 3334705 SGTC_3238 9133470 49.47 µM 0.178675545670959 0.436690915166174 no 1439 0.429096235945457 472 3534688 SGTC_1440 4100-1550 40 µM 0.178658434863652 0.436697956395598 no 1440 0.429102954081828 477 742806 SGTC_274 sirtinol 40.1 µM 0.177092381836916 0.43734248395609 no 1441 0.429717912882405 415 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.176548655451158 0.437566299934579 no 1442 0.429931463707272 476 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2321 7390090 138.78 µM 0.175254408574242 0.438099135513227 no 1443 0.430439866975327 457 649046 SGTC_3031 9088762 49.47 µM 0.175230578957613 0.438108947113783 no 1444 0.430449228757769 440 205253 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.175015707577368 0.438197419921145 no 1445 0.430533645607664 454 2374 Ca(2+)-ATPase inhibitor. SGTC_2816 7982706 58.44 µM 0.174521966832132 0.43840072825921 no 1446 0.430727634316585 453 2981853 SGTC_2109 5483026 200 µM 0.174510973754115 0.438405255079996 no 1447 0.430731953642151 493 759335 SGTC_187 1488-2104 32.728 µM 0.173119258133908 0.438978412166856 no 1448 0.431278843850053 479 2852859 SGTC_320 4092-0846 5.34 µM 0.172733452753267 0.439137323000273 no 1449 0.431430473759507 459 1359356 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.172586466177983 0.43919786843715 no 1450 0.431488245341464 439 688664 SGTC_1237 0330-0133 46.1 µM 0.172567710688704 0.439205594138195 no 1451 0.431495617101674 468 X1237 YHR072W ERG7 SGTC_1178 0988-0033 191 µM 0.172381806461332 0.439282172463735 no 1452 0.431568687207108 467 5392207 SGTC_290 2043-6722 48.1 µM 0.172315620028123 0.439309436761595 no 1453 0.431594702509871 468 773758 YLR208W SEC13 SGTC_1959 st077091 55.8 µM 0.170916776483784 0.439885732071101 no 1454 0.432144602520256 474 821356 YKL052C ASK1 SGTC_1522 st012842 45.6 µM 0.169284682207059 0.440558282925151 no 1455 0.432786361961534 497 3491067 YOR116C RPO31 SGTC_2445 5742597 35.57 µM 0.169219958796838 0.440584957595059 no 1456 0.432811815665107 460 1774255 SGTC_3228 9131799 49.47 µM 0.168040500514275 0.441071098683225 no 1457 0.433275708637549 459 17015818 SGTC_1794 st048918 76.9 µM 0.166747766389883 0.44160403102681 no 1458 0.433784259752695 473 672303 SGTC_1676 st018489 23.4 µM 0.166470577754118 0.441718316420601 no 1459 0.433893317815374 490 3696235 SGTC_2273 7815444 169.05 µM 0.165620871428801 0.442068682124708 no 1460 0.434227660556003 498 2824616 SGTC_2223 6903751 107.57 µM 0.165264934375538 0.442215461772239 no 1461 0.4343677287891 484 5598863 SGTC_2011 4012611 177 µM 0.16523026695259 0.442229758185321 no 1462 0.434381371542689 471 2049887 SGTC_2663 amphotericin b 100 µM 0.163946914909398 0.442759049363066 no 1463 0.434886466989759 465 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1483 3453-0561 55.9 µM 0.163809564213884 0.442815702797344 no 1464 0.43494053111809 473 4546991 SGTC_1355 1499-0035 1.68 µM 0.163793529566271 0.442822316730553 no 1465 0.434946842772623 466 1548538 SGTC_802 4112-3352 742 µM 0.162348549830959 0.443418403719709 no 1466 0.435515692259277 431 704594 SGTC_2183 6420625 130.508 µM 0.161910619918891 0.443599085112562 no 1467 0.43568811984188 444 2897619 SGTC_2204 7233102 200 µM 0.161563234475212 0.443742417954605 no 1468 0.435824905751123 474 2172480 SGTC_2963 9082507 9 µM 0.161378913696566 0.443818472550793 no 1469 0.435897486710032 466 16459611 SGTC_64 000l-0018 272.079 µM 0.16114720495401 0.443914083344187 no 1470 0.435988730938465 458 6811119 SGTC_271 rotenone 740 µM 0.160590366136733 0.444143867042793 no 1471 0.436208021560791 478 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1553 gossypol 38.6 µM 0.159977346019742 0.444396856086305 no 1472 0.436449459810824 492 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_168 3970-0862 530.542 µM 0.159245411750058 0.444698949820831 no 1473 0.436737763460344 462 3135186 SGTC_391 gliotoxin 8.33 µM 0.158235372509305 0.44511587948809 no 1474 0.43713566581321 468 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_567 1080-0542 68.4 µM 0.158082004283455 0.445179193006422 no 1475 0.437196090401639 475 5950415 SGTC_2677 mitomycin C 100 µM 0.155933760192278 0.446066178043274 no 1476 0.43804261700399 466 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1753 st043925 64 µM 0.155579985266481 0.446212273609736 no 1477 0.438182051129072 477 670181 SGTC_2486 5283202 22.39 µM 0.155032120388785 0.446438535335308 no 1478 0.438397997512622 456 1377751 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.152417836416145 0.447518442644373 no 1479 0.439428695003685 441 94937 An inhibitor of serotonin biosynthesis. SGTC_1844 rapamycin 4 nM 0.151475154108567 0.447907941333468 no 1480 0.439800454411673 480 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_925 2064-1272 59.6 µM 0.151045321113421 0.448085556979925 no 1481 0.439969982458206 467 6815817 SGTC_466 geldanamycin 89.2 µM 0.15092088375035 0.448136978947721 no 1482 0.440019063163939 481 5288382 HSP90 inhibitor. SGTC_686 1319-0111 510 µM 0.150657475577108 0.448245831497134 no 1483 0.440122959911516 489 4562600 SGTC_1614 st002383 48.6 µM 0.15031741861203 0.448386364665852 no 1484 0.440257095531041 476 1947235 SGTC_539 4859-0462 2.54 µM 0.148903559537883 0.448970730423441 no 1485 0.440814866212598 448 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1933 st074711 15.9 µM 0.146658359401797 0.449898926911587 no 1486 0.44170084375139 499 17250958 SGTC_1604 st002052 72.4 µM 0.145493824652675 0.450380469828336 no 1487 0.442160495543161 449 6254834 YHR062C RPP1 SGTC_2997 9067075 71.4286 µM 0.145442694545905 0.450401614149258 no 1488 0.442180678821503 489 27209819 SGTC_2924 9010168 62.78 µM 0.145295183695461 0.45046261650748 no 1489 0.442238908614859 460 2993929 SGTC_3313 9133968 57.047 µM 0.145222014230785 0.450492875799917 no 1490 0.442267792667208 497 1494643 SGTC_1454 4239-0054 42.6 µM 0.144927776901802 0.450614560793512 no 1491 0.442383947583305 505 1340767 SGTC_2837 9008476 45.46 µM 0.144733067813975 0.450695087371858 no 1492 0.442460814850134 491 2992805 SGTC_1761 st044296 37 µM 0.144704279622884 0.450706993585891 no 1493 0.442472180038041 463 1826700 SGTC_1928 4'-methoxychalcone 40.3 µM 0.144626190162955 0.450739290031663 no 1494 0.442503008937466 486 641818 SGTC_2254 7938975 95.19 µM 0.143620961521655 0.451155064205177 no 1495 0.442899893681566 470 2969277 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.143608438744121 0.451160244109502 no 1496 0.442904838291419 474 6708784 An antioxidant flavonoid SGTC_473 2-arachidonoylglycerol 10 µM 0.143242741198431 0.451311514399015 no 1497 0.443049237627009 491 5282280 An endocannabinoid. SGTC_2086 5274770 176.623 µM 0.142694348526656 0.451538369522474 no 1498 0.443265790132319 472 689278 SGTC_1529 apigenin 74 µM 0.142463638626013 0.451633812663516 no 1499 0.44335689927517 494 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3020 9089140 49.47 µM 0.142207229387924 0.451739890728378 no 1500 0.443458160800569 465 17217859 SGTC_706 4262-0057 46.9 µM 0.141967482802446 0.451839078469616 no 1501 0.443552845226307 468 883298 SGTC_599 1935-0052 86.5 µM 0.14105749438386 0.452215585367509 no 1502 0.443912261198046 477 9557311 SGTC_1217 1183-1422 255 µM 0.141014303704611 0.452233456543546 no 1503 0.443929321267584 470 2849664 SGTC_3166 9102297 49.47 µM 0.140424199865862 0.452477635792503 no 1504 0.444162419279696 474 25237072 SGTC_2979 9012552 45.46 µM 0.140363008987205 0.452502957015134 no 1505 0.444186591508918 482 17100905 SGTC_1853 st056710 91.2 µM 0.140168563063574 0.452583421408844 no 1506 0.444263404848434 496 269167 SGTC_351 caspofungin 25 nM 0.139852210366546 0.452714336659496 no 1507 0.444388380349863 464 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2413 inermin 26.06 µM 0.139398372633126 0.452902155887433 no 1508 0.444567679128033 489 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1917 st066507 28.5 µM 0.138001973759509 0.453480116800971 no 1509 0.445119428819908 470 3156428 SGTC_3351 9150312 21.596 µM 0.137889437968113 0.453526698980709 no 1510 0.445163898974204 496 4904905 SGTC_2174 5790901 200 µM 0.136711793829764 0.4540142019616 no 1511 0.445629303469317 488 786020 SGTC_1170 0310-0127 64.8 µM 0.136197754599294 0.454227017771281 no 1512 0.445832475099294 483 774975 SGTC_410 α-linolenic acid 100 µM 0.135943571671846 0.454332256127268 no 1513 0.445932944985824 503 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1674 st016616 23.6 µM 0.135165603976628 0.454654374918155 no 1514 0.44624047076528 470 625830 SGTC_2954 9074818 52.69 µM 0.135164319581098 0.454654906748932 no 1515 0.446240978505615 492 16648742 SGTC_1787 fluconazole 80 µM 0.133541718249203 0.455326843295446 no 1516 0.446882486658473 481 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2515 chrysin 20.77 µM 0.130618065457537 0.456537880518193 no 1517 0.448038725499129 472 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2208 7283366 200 µM 0.130103517540718 0.456751058974314 no 1518 0.44824226359114 489 898663 SGTC_2367 9070478 135.38 µM 0.129386355599013 0.45704820166623 no 1519 0.448525971791563 479 572802 SGTC_2158 5657123 3.6195 µM 0.125091264306329 0.458828289614149 no 1520 0.450225649524081 501 2858827 SGTC_119 0121-0043 24.815 µM 0.124869845722129 0.458920078585968 no 1521 0.450313295557139 486 1092378 SGTC_297 0986-0032 24 µM 0.124682693205143 0.458997664283638 no 1522 0.450387379646438 487 2847425 SGTC_2840 9008771 71.43 µM 0.124653975641597 0.459009569536741 no 1523 0.450398747611027 498 2992978 SGTC_1788 fluconazole 20 µM 0.123054870990122 0.459672557640688 no 1524 0.451031823663848 494 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3182 9108849 49.47 µM 0.122927325649441 0.459725442738211 no 1525 0.451082323494132 469 17133045 SGTC_2181 6316240 54.2555 µM 0.122670098971713 0.459832100764487 no 1526 0.451184171280975 460 12779990 SGTC_175 3793-3120 23.7 µM 0.12264117167685 0.459844095534046 no 1527 0.451195625119001 507 5322297 SGTC_1109 tnp00067 928.257 nM 0.120836996130586 0.460592272872002 no 1528 0.451910073061628 487 676295 SGTC_428 3448-4153 16.5 µM 0.120756113078489 0.46062581772198 no 1529 0.451942106165781 442 3834874 SGTC_617 3770-0098 35 µM 0.119278341753274 0.461238746962727 no 1530 0.452527420882659 496 5962639 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.118883085432712 0.46140270149874 no 1531 0.452683991293679 478 115019 SGTC_2299 7976368 114.88 µM 0.118845703062145 0.461418208255467 no 1532 0.452698799719229 471 2979718 SGTC_1882 5615643 20 µM 0.118675804589931 0.46148868537753 no 1533 0.452766103098245 486 2253075 SGTC_1262 0737-0114 49.6 µM 0.11802433097453 0.461758940231532 no 1534 0.453024189644068 512 765919 SGTC_1436 4092-1007 8.32 µM 0.117507245077535 0.461973458768312 no 1535 0.453229051539473 481 2881121 SGTC_3207 9114163 49.47 µM 0.116370318346255 0.462445163626019 no 1536 0.453679529036919 486 849233 SGTC_1939 st074455 53.6 µM 0.115373328189923 0.462858853034036 no 1537 0.454074609395181 514 1644229 SGTC_1714 st033236 13.627 µM 0.114285523473841 0.463310270695857 no 1538 0.454505728950441 491 2916566 SGTC_1045 1348-1485 165 µM 0.114262092598426 0.463319994572346 no 1539 0.45451501568351 476 6810614 SGTC_1409 3909-8004 61.9 µM 0.113776282846187 0.46352161185887 no 1540 0.454707570015974 487 2119279 SGTC_1498 4478-3555 97.6 µM 0.113484051701106 0.463642896053754 no 1541 0.454823403147914 507 3437919 SGTC_558 k064-0027 21.3 µM 0.113133733897213 0.46378829230817 no 1542 0.454962265443489 478 5088526 SGTC_705 1124-0212 310 µM 0.113034184785457 0.463829610155178 no 1543 0.455001726670033 505 9554485 SGTC_2143 5623677 140.463 µM 0.112034663458487 0.464244482911945 no 1544 0.455397961055535 502 5375313 SGTC_84 0443-0269 128.823 µM 0.111813087905858 0.464336457876281 no 1545 0.455485804976515 509 6150058 SGTC_416 estradiol valerate 100 µM 0.111241653297333 0.464573666463952 no 1546 0.455712361016636 494 13791 A steroid. SGTC_449 xestospongin c 11.1929 µM 0.111014253505603 0.464668066044728 no 1547 0.455802521967772 493 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1972 st070201 17.4 µM 0.110947768574404 0.464695666048569 no 1548 0.455828882776721 494 2829099 SGTC_368 fentichlor 4.58 µM 0.110418806154024 0.464915261168954 no 1549 0.456038619584959 497 7329 A pesticide. SGTC_432 NS 1619 61.3 µM 0.107655179071611 0.466062734229942 no 1550 0.457134612360381 462 4552 A K+/calcium channel activator. SGTC_2267 7931562 200 µM 0.106844348592749 0.466399449441043 no 1551 0.457456231866482 461 934880 SGTC_1005 4092-0690 4.4 µM 0.106358538567931 0.466601204289148 no 1552 0.457648943929843 496 1529343 SGTC_156 3474-0145 5.642 µM 0.104884364351487 0.467213474925639 no 1553 0.458233782985293 496 2265471 SGTC_228 caffeine 993.056 µM 0.104875791524897 0.467217035716819 no 1554 0.458237184289858 482 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2835 9006588 71.43 µM 0.101997395075358 0.468412746926967 no 1555 0.459379371365181 434 2345538 SGTC_176 1486-1328 72.834 µM 0.101965674791893 0.46842592541929 no 1556 0.459391960293002 476 22310231 SGTC_609 0986-0026 86.3 µM 0.101819630554949 0.468486601327469 no 1557 0.459449921849869 500 2848610 SGTC_2802 7925815 54.55 µM 0.101755913861876 0.468513073455413 no 1558 0.459475209791766 476 1262923 SGTC_2000 st075254 36.4 µM 0.100903981183418 0.468867035957984 no 1559 0.459813341356846 471 17234175 SGTC_1266 0828-0227 32.9 µM 0.100164591890123 0.469174258693058 no 1560 0.460106828090867 485 3913820 SGTC_3309 9129340 25.759 µM 0.099046966353201 0.469638676686355 no 1561 0.460550489827266 493 17158987 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0977651474565656 0.47017137438958 no 1562 0.461059391532396 509 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1860 st056228 74.6 µM 0.0963316522478764 0.470767168857142 no 1563 0.461628586559168 516 688679 SGTC_951 1171-0579 82.7 µM 0.0958889555927945 0.470951177330698 no 1564 0.461804383159613 499 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2597 laccaic acid a 100 µM 0.0955373532555094 0.471097326540974 no 1565 0.461944011163495 498 5491415 A textile dye. SGTC_2395 5646831 180.19 µM 0.0953928694756637 0.471157384695444 no 1566 0.462001389792857 503 6808628 SGTC_433 pimozide 108 µM 0.0948924684104732 0.471365393482262 no 1567 0.46220011943126 473 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_366 0181-0206 4.31 µM 0.0929836128086594 0.47215894573121 no 1568 0.46295828994969 478 274874 SGTC_1064 honokiol 6.76 µM 0.0925653255323727 0.472332851604297 no 1569 0.463124445827186 510 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2617 dihydrotanshinone i 20.83 µM 0.0921371176091593 0.472510887519374 no 1570 0.463294549138262 507 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2003 4023581 200 µM 0.0917666725018151 0.472664911833215 no 1571 0.463441711894717 495 16641307 SGTC_3197 9113331 49.47 µM 0.090343849380566 0.473256533512712 no 1572 0.464006987915006 477 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2485 5633444 17.78 µM 0.0902170592135935 0.473309256800038 no 1573 0.464057364157123 504 5724239 SGTC_419 nsc-638432 893 µM 0.0879475336645635 0.47425307418843 no 1574 0.464959188271145 474 368090 SGTC_768 0384-0033 77.3 µM 0.086686335590305 0.474777625775092 no 1575 0.465460419073449 477 3965305 YMR134W ERG29 SGTC_745 0469-0705 296 µM 0.0845145934994474 0.475680988520465 no 1576 0.46632365020904 510 3486736 SGTC_520 3584-0023 682 µM 0.0839158753979629 0.475930054835405 no 1577 0.46656165866951 470 1340790 SGTC_1721 st082152 9.2685 µM 0.0834972098259843 0.476104225016449 no 1578 0.466728097941577 494 5296051 SGTC_140 0062-0056 502.533 µM 0.0831464795367124 0.476250136775214 no 1579 0.466867534220957 494 3758964 SGTC_664 1222-0054 14.9 µM 0.08026705201266 0.477448162584577 no 1580 0.468012431160555 503 6813991 SGTC_2364 9055074 200 µM 0.0785292493795712 0.478171298830603 no 1581 0.468703532209011 495 6470630 SGTC_1733 st037357 54.9 µM 0.0784113347926967 0.47822036820215 no 1582 0.468750428716016 517 1272339 YGL099W LSG1 SGTC_2159 5658611 73.75 µM 0.0780658598326687 0.478364137208345 no 1583 0.468887832097334 503 793844 SGTC_2191 5911152 200 µM 0.0771595964693496 0.478741290993647 no 1584 0.469248291565015 494 2875902 SGTC_2290 7904846 200 µM 0.0771195285258538 0.478757966253473 no 1585 0.469264228873579 492 2962154 SGTC_2008 4012253 172 µM 0.0770612834917404 0.478782206422779 no 1586 0.469287396336613 519 603940 SGTC_1124 fisetin 1.16336 µM 0.076768603828592 0.478904013780035 no 1587 0.469403813761223 484 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_139 0099-0334 718.624 µM 0.0761823427197579 0.47914800971303 no 1588 0.469637015164538 512 97690 SGTC_103 0844-0104 51.839 µM 0.0756254242943366 0.479379800757482 no 1589 0.469858554360312 500 5375804 SGTC_1383 3049-0032 20.7 µM 0.0751050443825435 0.479596390671675 no 1590 0.470065567163132 520 712864 SGTC_2972 9093619 59.92 µM 0.0748293802922183 0.479711128640433 no 1591 0.470175232625724 454 25236256 SGTC_148 3253-0744 288.01 µM 0.0746941887325705 0.479767399206764 no 1592 0.470229015738924 515 6893655 SGTC_1998 st075797 76.8 µM 0.0737917654528331 0.48014302367783 no 1593 0.470588039689593 521 24208315 SGTC_1230 0170-0365 3.77 µM 0.0733063963416701 0.480345060925701 no 1594 0.470781150926288 516 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1807 st050092 58.9 µM 0.0722912583979855 0.48076763328362 no 1595 0.471185060641909 499 5008496 SGTC_2784 7567673 72.73 µM 0.0717499466335364 0.480992974469598 no 1596 0.47140045344629 526 3471247 SGTC_458 nppb 133 µM 0.0716583408123971 0.481031109407844 no 1597 0.471436905053227 498 4549 A chloride channel blocker. SGTC_1646 st011709 75.6 µM 0.0713934783276287 0.481141371001686 no 1598 0.471542299953656 523 5757843 SGTC_1052 3253-3998 198 µM 0.0711656027642283 0.48123623618705 no 1599 0.471632978498976 502 5450317 SGTC_3074 9116018 49.47 µM 0.0705352025336009 0.481498678949905 no 1600 0.471883841371423 525 17027303 SGTC_3129 9127257 49.47 µM 0.0700758689355769 0.481689909790496 no 1601 0.472066636637696 503 837894 SGTC_537 1334-0398 209 µM 0.0692090890154721 0.482050781080392 no 1602 0.472411594234634 493 5846986 SGTC_1050 3232-1156 69.3 µM 0.0681660876959713 0.482485039072437 no 1603 0.472826711127193 522 700529 SGTC_2664 lyso-paf C-16 73.48 µM 0.0667408991770292 0.48307845581108 no 1604 0.473393987022717 502 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_933 2914-0560 114 µM 0.0661498417171851 0.483324570037982 no 1605 0.473629264882123 484 463887 SGTC_400 oxethazaine 37.5 µM 0.0656006471043125 0.483553258420972 no 1606 0.473847886955154 510 4621 A local anesthetic. SGTC_2088 5278280 127.392 µM 0.0653721516850492 0.483648407070352 no 1607 0.473938848187132 502 791502 SGTC_685 1278-0033 54.9 µM 0.0651242549369885 0.483751635754051 no 1608 0.474037534387349 529 3590572 SGTC_2079 5212404 121 µM 0.064751022832896 0.483907058396065 no 1609 0.47418611884005 498 758462 SGTC_2754 granisetron 64.02 µM 0.0645427530636505 0.483993787899563 no 1610 0.474269033017136 522 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2 0422-0095 29 µM 0.0641537497820155 0.484155782044723 no 1611 0.47442390190767 488 6790840 SGTC_790 1575-0012 79.1 µM 0.0639997144733483 0.484219928289976 no 1612 0.474485227080303 526 378741 YLR208W SEC13 SGTC_2733 amorolfine 100 µM 0.0638611907250154 0.484277615271896 no 1613 0.474540377242883 525 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2490 carminic acid 95.39 µM 0.0624626104057007 0.484860059825446 no 1614 0.47509721817321 517 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1301 naphtanilide LB 4.81 µM 0.0619598120084949 0.485069460254808 no 1615 0.475297417925161 521 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1974 st069448 26.9 µM 0.0615902573860966 0.485223371282887 no 1616 0.475444567846631 512 6323587 YNR016C ACC1 SGTC_1812 st052057 4.327 µM 0.0613728016654819 0.485313937635547 no 1617 0.475531156321497 506 3645418 SGTC_557 1315-0110 16.2 µM 0.0601395326297566 0.485827585952672 no 1618 0.476022252220877 518 6833801 SGTC_70 0141-0289 43.283 µM 0.0592812744951838 0.486185058661268 no 1619 0.476364037834739 512 352408 SGTC_827 3253-0474 693 µM 0.05925662645379 0.486195324971233 no 1620 0.476373853724759 509 5402065 SGTC_1843 st055809 45.5 µM 0.0585314090512441 0.486497393875891 no 1621 0.476662672283863 503 16413835 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0581970405501346 0.486636668287316 no 1622 0.476795839013886 534 688669 SGTC_2801 7907800 81.82 µM 0.0573450774152755 0.486991543564005 no 1623 0.477135156411663 527 6620925 SGTC_2378 9074213 121.43 µM 0.0563802201046559 0.487393456012756 no 1624 0.477519456978856 526 657714 SGTC_97 0535-0701 19.132 µM 0.0562941195001152 0.487429321949238 no 1625 0.477553751683576 502 2832013 YGL099W LSG1 SGTC_2593 nobiletin 86.24 µM 0.0561722894161801 0.487480071476791 no 1626 0.477602278069946 514 72344 An anti-infammatory. SGTC_2705 st078069 42.8 µM 0.0560990616905194 0.487510575308457 no 1627 0.477631445712836 510 1530061 SGTC_1435 4092-0789 56.7 µM 0.0554680662222671 0.487773426567164 no 1628 0.477882785115585 527 2248285 SGTC_2806 7952793 58.44 µM 0.0554288090530373 0.487789779945823 no 1629 0.477898422403064 518 2972490 SGTC_2031 5180455 200 µM 0.0550575181444437 0.487944449797165 no 1630 0.478046320193947 533 29949 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0549544045275474 0.48798740449183 no 1631 0.478087394390178 504 2724 A muscle relaxant with antifungal properties. SGTC_795 0685-0265 78 µM 0.0539291228266105 0.488414520106075 no 1632 0.478495816880575 518 302754 SGTC_2913 7966556 36.57 µM 0.0515943159863825 0.489387211314011 no 1633 0.479425974247688 533 2976516 SGTC_1088 bifonazole 369 nM 0.050701664523635 0.48975911099087 no 1634 0.47978162512951 530 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3296 9122258 64.045 µM 0.0501501477253649 0.489988890382069 no 1635 0.480001368939031 515 4730474 SGTC_774 k060-0086 136 µM 0.0493283420469056 0.490331286834752 no 1636 0.480328816659014 532 5911235 SGTC_2066 5222451 176 µM 0.0477659780606606 0.490982248341287 no 1637 0.480951375583066 534 2281147 SGTC_2420 aureobasidin a 50 nM 0.0476570571796176 0.491027631319917 no 1638 0.480994779297719 476 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0473578215509085 0.491152311444998 no 1639 0.481114022402147 532 140250 A respiratory chain inhibitor. SGTC_1866 st057638 64 µM 0.0472790280664081 0.491185141842632 no 1640 0.481145421283272 519 688802 SGTC_3225 9130819 49.47 µM 0.0471853589826262 0.491224170442601 no 1641 0.481182748181998 523 4547121 SGTC_2282 7944268 200 µM 0.0466870085888287 0.491431816859643 no 1642 0.481381342349956 515 2970414 SGTC_3027 9089541 49.47 µM 0.0463102891875726 0.491588785138131 no 1643 0.481531469261794 522 9943819 SGTC_3323 9138564 53.9225 µM 0.0462011949492867 0.491634241854059 no 1644 0.481574945030846 516 43912313 YNL103W MET4 SGTC_124 0136-0217 7.121 µM 0.0456380441945487 0.491868893760267 no 1645 0.481799372933788 519 3976905 SGTC_2665 lovastatin 100 µM 0.0454520807270312 0.491946381061933 no 1646 0.481873484716619 524 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_760 0568-0725 82.9 µM 0.0453827499799705 0.49197526989196 no 1647 0.481901115171003 534 3916171 SGTC_2198 6589944 200 µM 0.0444067551410874 0.492381953146325 no 1648 0.482290088569188 525 5290268 SGTC_2484 5809818 12.04 µM 0.0437777467759995 0.492644056264222 no 1649 0.48254078278749 529 2870548 SGTC_87 0100-0052 35.5 µM 0.0437636132802149 0.492649945623937 no 1650 0.48254641583784 525 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_896 0964-0007 44.5 µM 0.0434458359439396 0.492782362332093 no 1651 0.482673070186731 508 6756758 SGTC_1405 3909-7894 12 µM 0.0421113286103218 0.493338455399003 no 1652 0.483204974628999 533 7104060 SGTC_1929 genistein trimethyl ether 50.5 µM 0.04197577313098 0.493394942501843 no 1653 0.483259005665642 534 136420 SGTC_3150 9097574 49.47 µM 0.041817168864626 0.493461034395207 no 1654 0.483322224104806 522 17217476 SGTC_1652 st011932 78 µM 0.0407755164287353 0.49389510516463 no 1655 0.48373742909044 526 1551076 SGTC_1611 st001856 99.4 µM 0.0399767710775946 0.494227958164329 no 1656 0.484055822740111 536 647478 SGTC_3050 9093513 49.47 µM 0.0394790803279199 0.494435357798769 no 1657 0.484254215996043 530 25236664 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.0380540931888418 0.495029192135224 no 1658 0.484822276552003 522 1609 A potent and irreversible inhibitor of serine proteases. SGTC_269 exalamide 29 µM 0.0379643159137531 0.49506660536678 no 1659 0.48485806664054 532 3316 A derivative of salicylamide. SGTC_2681 menadione 3.18 µM 0.0360370688257637 0.495869764432855 no 1660 0.485626400745462 533 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_209 4077-0173 175.592 µM 0.0351705101859598 0.496230898883474 no 1661 0.485971888569779 525 15993494 SGTC_1539 benzyladenosine 56 µM 0.0346454755825216 0.496449706235785 no 1662 0.486181219488522 522 92208 A nucleotide analog. SGTC_794 k038-0031 316 µM 0.0340862797707935 0.496682751391368 no 1663 0.486404174642533 535 6624242 SGTC_3049 9092223 49.47 µM 0.033854907385992 0.496779176292934 no 1664 0.486496425624909 529 8623917 SGTC_1444 4112-3581 28 µM 0.0330314727805655 0.497122345790072 no 1665 0.486824744839727 531 2877249 SGTC_2778 tioconazole 65.09 nM 0.0328631393905282 0.497192499639713 no 1666 0.486891863706645 530 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2940 9060638 45.86 µM 0.0328462204672352 0.497199550697229 no 1667 0.486898609738568 518 4027022 SGTC_2123 5259487 200 µM 0.0325055027747719 0.497341546916766 no 1668 0.487034463885206 532 2173474 SGTC_178 4092-0806 87.505 µM 0.031748550103436 0.49765701283419 no 1669 0.487336288499156 531 2169044 SGTC_754 3474-0146 171 µM 0.0312162927908434 0.49787883610095 no 1670 0.487548523239158 537 24762078 SGTC_1248 0469-0687 58.6 µM 0.0311952630404377 0.497887600462157 no 1671 0.487556908811809 530 4017482 SGTC_598 3937-0236 20.2 µM 0.0310789078372815 0.497936092688365 no 1672 0.487603305325285 534 1379313 SGTC_516 3992-2719 87.3 µM 0.0305366165280573 0.498162098553058 no 1673 0.487819545611031 523 5350887 YDR037W KRS1 SGTC_1757 st041620 31.8375 µM 0.028333676864706 0.49908020317911 no 1674 0.488698010560663 522 5289815 SGTC_2514 salinomycin 42.74 µM 0.0279005429508904 0.49926071826832 no 1675 0.488870737700505 534 23682228 A polyether potassium ionophore. SGTC_3347 9188721 44.724 µM 0.0271553279912337 0.49957129817229 no 1676 0.489167922826144 540 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2851 9015922 71.43 µM 0.0266404603759346 0.499785877407432 no 1677 0.489373250993866 538 2996893 SGTC_1524 corynanthine 62.1 µM 0.0262065190037712 0.499966729399357 no 1678 0.489546308128218 520 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_476 mead acid 10 µM 0.0260468581768048 0.499966729399357 no 1679 0.489609981846879 521 5312531 An omega 9 fatty acid. SGTC_2218 6965428 192.983 µM 0.0255631086392008 0.499765119061732 no 1680 0.48980290574424 531 675684 SGTC_1846 st056244 14.8 µM 0.0255274891227404 0.49975027406171 no 1681 0.489817111239621 515 5393182 SGTC_958 1222-0007 33 µM 0.0249354094612912 0.499503515511941 no 1682 0.490053241671137 535 7312461 SGTC_258 haloperidol 50.781 µM 0.0230829077813758 0.4987314578394 no 1683 0.490792069834524 544 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1416 3966-0321 25.3 µM 0.0221454704729302 0.498340768504718 no 1684 0.49116595758279 537 582530 YLR208W SEC13 SGTC_696 1560-0013 611 µM 0.0218214561869272 0.498205731638152 no 1685 0.491295189349503 531 1650269 SGTC_1309 pyrazolanthrone 13.4 µM 0.0211435795007789 0.497923219026169 no 1686 0.491565560620154 540 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2075 5212009 200 µM 0.0209601310834903 0.497846765040918 no 1687 0.491638729734618 542 780898 SGTC_2065 5221596 34.26 µM 0.0207037490275814 0.497739915356462 no 1688 0.491740989185216 538 788581 SGTC_1311 1190-0148 100 µM 0.018485663241817 0.496815514384618 no 1689 0.492625707344203 543 1961333 SGTC_223 busulfan 5 mM 0.0178686440823209 0.496558370660555 no 1690 0.492871821708292 541 2478 A DNA alkylator. SGTC_3143 9086658 49.47 µM 0.0155564474531294 0.495594772597471 no 1691 0.493794125685873 537 25236626 SGTC_1324 1418-0026 34.4 µM 0.0141383954710357 0.495003817851034 no 1692 0.494359784177957 530 1372513 SGTC_1782 st039423 80.636 µM 0.0135880760652537 0.494774482267824 no 1693 0.494579308757727 535 2068169 SGTC_1672 st016598 6.51 µM 0.0134909672954335 0.494734014134838 no 1694 0.494618046000999 537 4665860 YNL267W PIK1 SGTC_2985 9022375 71.43 µM 0.013330436288203 0.494667116174937 no 1695 0.494682082848356 529 4939335 SGTC_376 3970-0862 59.1 µM 0.0125731518662582 0.494351535689588 no 1696 0.494984170276851 542 3135186 SGTC_2700 st077718 96.8 µM 0.0123790962847154 0.494270668147723 no 1697 0.495061581228071 539 904970 SGTC_932 2857-0803 154 µM 0.0121001096303613 0.49415440823628 no 1698 0.495172872463335 538 674898 SGTC_1456 k015-0012 13 µM 0.0114980723056235 0.493903527667758 no 1699 0.495413033884882 535 2989616 SGTC_1685 st024049 53.0905 µM 0.010516253461006 0.493494390030214 no 1700 0.495804699190625 541 1941139 SGTC_2561 acetosyringone 100 µM 0.0100642224109992 0.493306024647325 no 1701 0.495985023939536 541 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1723 st034307 2.5525 µM 0.00990682635272919 0.493240436649812 no 1702 0.496047812751447 545 867466 SGTC_3276 9139060 49.47 µM 0.00990118260482731 0.493238084865435 no 1703 0.496050064170682 543 4870619 SGTC_2179 6298986 200 µM 0.0086768432962691 0.492727900858875 no 1704 0.496538483783635 544 738374 SGTC_2284 7945075 39.21 µM 0.00837688728063522 0.492602910524208 no 1705 0.49665814456989 543 1245402 SGTC_3295 9122362 53.5725 µM 0.00816490885183833 0.492514580495071 no 1706 0.496742708835037 537 4730473 SGTC_584 0986-0246 15.4 µM 0.00650070345867629 0.491821130054351 no 1707 0.497406612803716 541 53315 YDR232W HEM1 SGTC_3109 9122853 49.47 µM 0.00622071102031772 0.491704463606218 no 1708 0.497518311365599 544 1234709 SGTC_1506 4226-2149 212 µM 0.00613738436889439 0.491669743432078 no 1709 0.497551553255322 542 991114 SGTC_1895 st058434 18.3 µM 0.00431394367480704 0.490909976629839 no 1710 0.498278990810879 545 5393175 SGTC_3240 9133527 49.47 µM 0.00383090562061883 0.490708716226792 no 1711 0.498471693513905 545 17617455 SGTC_1032 k061-1018 98.7 µM 0.0036890119203849 0.490649595900694 no 1712 0.498528300510067 537 4005393 SGTC_34 0469-0683 81.75 µM 0.00204726556022337 0.489965573895607 no 1713 0.499183259779351 546 3690923 SGTC_3158 9100007 49.47 µM 0.00151638473327769 0.489744392372358 no 1714 0.499395050248379 546 19297233 SGTC_2830 7992007 71.43 µM 0.000634479067706549 0.489376969948741 no 1715 0.499746879490845 547 1952075 SGTC_2139 5578692 56.4705 µM 0.000562217443927804 0.489346864469993 no 1716 0.499775707702654 547 650991 YMR113W FOL3 SGTC_2167 5876490 200 µM 0.000195815937539984 0.489194216018046 no 1717 0.499921880743838 547 686534 SGTC_1727 st034309 9.9045 µM -8.16540436206328e-06 0.489109234966535 no 1718 0.499996742474963 548 870305 SGTC_2646 retinol 96.75 µM -7.51251858434227e-05 0.489081338833302 no 1719 0.499970029387072 547 445354 A vitamin A analog and teratogen. SGTC_966 1300-0360 30.2 µM -0.000853694935901176 0.488756982629342 no 1720 0.499659425036873 549 70588 SGTC_2272 7805186 180 µM -0.000930527469586654 0.488724974196137 no 1721 0.49962877330288 548 2956062 YPR165W RHO1 SGTC_213 1246-0773 967 nM -0.00119157903811596 0.48861622065757 no 1722 0.499524628853749 549 6251622 SGTC_3188 9110789 49.47 µM -0.00209090309985834 0.488241570661639 no 1723 0.499165850957043 550 849217 SGTC_2513 baicalein 25.65 µM -0.00249511950079848 0.488073181248301 no 1724 0.499004592369316 550 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2070 5230947 200 µM -0.00272228482620968 0.487978549117196 no 1725 0.498913966824932 550 2835538 SGTC_2089 5281248 129.67 µM -0.00281930334978373 0.487938133517491 no 1726 0.498875262182485 551 2737878 SGTC_1414 3917-0015 5.4 µM -0.00456007446519234 0.487212991296009 no 1727 0.498180799798884 550 6618702 SGTC_2807 7945238 51.95 µM -0.00466835899587692 0.487167885252858 no 1728 0.498137600981177 552 17148797 SGTC_856 0433-0016 11.3 µM -0.00570520047999025 0.486735996159851 no 1729 0.497723966657592 555 3911780 SGTC_2116 5511452 16.8835 µM -0.00583454006680757 0.486682121737457 no 1730 0.497672368486812 551 870744 SGTC_2804 7954240 19.48 µM -0.00659820474417656 0.48636403390825 no 1731 0.497367716252802 553 828705 SGTC_1381 2324-0066 62.1 µM -0.0080596543197702 0.485755323390835 no 1732 0.496784697936408 554 10885928 SGTC_1330 1469-0054 61.8 µM -0.00851650039136445 0.48556504850246 no 1733 0.496602448984049 551 7102664 SGTC_878 0828-0289 13.7 µM -0.00871234655072782 0.485483480224219 no 1734 0.496524320569692 550 745350 YLR208W SEC13 SGTC_204 PMA1.184 62.41 µM -0.00931957818044827 0.4852305772338 no 1735 0.496282080048093 551 2252213 YGL008C PMA1 SGTC_206 4546-0025 72.014 µM -0.00939247074273853 0.485200218957338 no 1736 0.496253001395806 556 6620745 YIL048W NEO1 SGTC_2261 9010538 184.68 µM -0.00946159741166877 0.485171429178462 no 1737 0.496225425070239 558 6457250 SGTC_362 0310-0100 9.03 µM -0.00991282185244544 0.484983505757093 no 1738 0.496045421010561 550 790235 SGTC_1233 0325-0408 14.2 µM -0.0116570030457981 0.484257130704174 no 1739 0.495349633942225 552 12874 SGTC_1954 st077032 68.9 µM -0.0116581921423693 0.484256635515094 no 1740 0.49534915959356 555 698907 SGTC_547 1120-0019 610 nM -0.0134021257902221 0.483530415819514 no 1741 0.494653485429631 556 3676939 SGTC_1304 1165-0502 251 µM -0.0137377881153809 0.483390643421945 no 1742 0.494519587865582 556 767425 SGTC_3106 9121286 49.47 µM -0.01495711161208 0.482882924954739 no 1743 0.494033198263449 556 15943471 SGTC_2937 9044753 11.33 µM -0.0151302217856565 0.48281084522207 no 1744 0.493964145110346 552 6465530 YGL099W LSG1 SGTC_1358 1509-0022 2.48 µM -0.0151317273078352 0.482810218354174 no 1745 0.493963544562645 554 3258434 SGTC_2898 9056270 58.44 µM -0.0153519043783025 0.482718541692984 no 1746 0.493875716822591 559 19154699 SGTC_55 0767-0285 6.563 µM -0.0164259697992944 0.482271338779014 no 1747 0.493447280819362 558 3116166 SGTC_3079 9117512 49.47 µM -0.0167567789553418 0.48213360599487 no 1748 0.493315325224075 555 7185044 SGTC_718 1130-0073 349 µM -0.0167758493312463 0.482125666086112 no 1749 0.493307718314086 562 6740020 SGTC_1505 k297-0037 20.6 µM -0.0170739934629091 0.482001535361259 no 1750 0.49318879304922 556 4089396 SGTC_1172 0370-0043 85 µM -0.0172709387096635 0.481919539210595 no 1751 0.493110234847501 563 376585 SGTC_350 k064-0020 19.8 µM -0.0173742427326805 0.481876529936742 no 1752 0.493069028687877 557 2790705 SGTC_3076 9116187 49.47 µM -0.0183376953969463 0.481475419291728 no 1753 0.492684727969061 561 27241210 SGTC_2558 carylophyllene oxide 100 µM -0.01848474336072 0.481414201002246 no 1754 0.492626074260972 554 6708694 An oxygenated terpenoid and antifungal agent. SGTC_772 k072-0172 35.3 µM -0.0191757600956956 0.4811265261858 no 1755 0.492350447344413 557 5861980 SGTC_593 1203-0218 61.7 µM -0.0195800771915466 0.480958210864708 no 1756 0.492189178442667 554 3666956 SGTC_2431 5490079 200 µM -0.020093138095592 0.480744630894213 no 1757 0.491984537024106 560 5722345 SGTC_2081 5214970 32.255 µM -0.0209512376196987 0.480387428628385 no 1758 0.491642276934398 559 2063512 SGTC_2475 5812728 15.03 µM -0.0218989667096565 0.479992934453026 no 1759 0.491264274512319 557 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1642 st009582 77.7 µM -0.022360782330823 0.479800709831375 no 1760 0.491080081844906 558 6739311 SGTC_1243 0416-0003 5.65 µM -0.023149938331045 0.479472245018826 no 1761 0.490765335658099 566 2141977 SGTC_459 nigericin 15.3 µM -0.0241378015232872 0.479061093391791 no 1762 0.49037134542156 560 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_73 0327-0325 16.231 µM -0.0253576352929496 0.478553425702808 no 1763 0.489884851185338 565 53298 SGTC_3029 9088683 49.47 µM -0.0253727731986003 0.478547125859977 no 1764 0.4898788139772 557 25236615 SGTC_1203 3992-3522 103 µM -0.0261115304119386 0.478239688663533 no 1765 0.489584190130199 558 5322312 SGTC_2815 7968870 71.43 µM -0.0277741590160862 0.477547825798073 no 1766 0.488921138063767 567 2977326 YHR190W ERG9 SGTC_949 1165-0505 146 µM -0.0293511978307785 0.476891641558156 no 1767 0.48829224725315 556 6244267 SGTC_759 3486-0358 89.3 µM -0.0310093885754324 0.476201758715475 no 1768 0.487631026137099 559 875103 SGTC_3047 9092122 49.47 µM -0.0316493460762327 0.475935526222927 no 1769 0.487375845301185 566 17173831 SGTC_2671 danthron 100 µM -0.0345706023163853 0.474720375425183 no 1770 0.486211071717443 557 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_548 1436-0017 110 µM -0.0345933764829744 0.474710902996548 no 1771 0.486201991570651 567 9677137 SGTC_2552 juarezic acid 87.02 µM -0.0351608208906294 0.474474891232628 no 1772 0.485975751650026 561 1549512 SGTC_2229 7354935 190 µM -0.0356975219745555 0.474251674488687 no 1773 0.485761773236083 564 318112 SGTC_3137 9097352 49.47 µM -0.0357045782601193 0.474248739796874 no 1774 0.48575895997884 562 44120435 SGTC_747 3448-8087 38.7 µM -0.0361511420849027 0.474063017849584 no 1775 0.485580921733678 576 5168703 SGTC_3120 9124077 49.47 µM -0.0364206034928696 0.473950953956242 no 1776 0.485473492932561 573 18774327 YGL155W CDC43 SGTC_2951 9072950 58.06 µM -0.0373750821396454 0.473554021016376 no 1777 0.485092970178746 559 16488155 SGTC_3184 9108758 49.47 µM -0.0376696375737407 0.473431531412135 no 1778 0.484975542256691 566 902885 SGTC_1258 0671-0043 57.1 µM -0.0377110092132537 0.473414327395571 no 1779 0.48495904907942 572 4298767 SGTC_106 0092-0003 11.579 µM -0.0382767014326023 0.473179094466423 no 1780 0.484733533366879 568 1072148 SGTC_3174 9107204 49.47 µM -0.0392494427237238 0.472774619420924 no 1781 0.484345757194237 577 3938802 SGTC_2645 abamectin 100 µM -0.0394420994335523 0.472694514252746 no 1782 0.484268957756425 561 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1661 st013063 9.66 µM -0.0409178160784814 0.472080959563224 no 1783 0.483680707082382 573 721395 SGTC_947 3447-0010 211 µM -0.0415453832146889 0.471820057676535 no 1784 0.483430556745848 574 748350 SGTC_927 2425-1185 123 µM -0.0424212986472913 0.471455928848 no 1785 0.483081424882572 583 730375 SGTC_23 0213-0011 39.996 µM -0.0425353264027487 0.471408527855024 no 1786 0.48303597541298 577 627608 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0433582909975658 0.471066436013795 no 1787 0.482707962687598 569 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_245 methotrexate 289.6 µM -0.0441573893976894 0.470734285354413 no 1788 0.482389473617305 568 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1255 0566-0045 221 µM -0.0444071118760524 0.470630490680152 no 1789 0.482289946392781 578 2788469 SGTC_257 daunorubicin 18.5 µM -0.0463274842668348 0.469832374110214 no 1790 0.481524616772406 560 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_281 1672-3440 14.9 µM -0.0469453222974753 0.469575623082887 no 1791 0.481278402960966 565 6833000 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0472682545213275 0.469441429216332 no 1792 0.481149714505992 565 368090 SGTC_456 gingerol 170 µM -0.0474729486578625 0.469356370756752 no 1793 0.481068144931879 583 442793 A herb. SGTC_1979 st071809 45.3 µM -0.0478485213643609 0.469200309174453 no 1794 0.48091848317909 598 4976333 SGTC_861 0443-0273 110 µM -0.0484194172771598 0.468963094086433 no 1795 0.480690992351916 584 6149169 SGTC_2149 5554786 194.827 µM -0.049533900296596 0.46850004291811 no 1796 0.48024691090914 578 745063 YPR165W RHO1 SGTC_1235 benzylparaben 21.5 µM -0.0498128207621673 0.46838416224277 no 1797 0.48013577493835 582 7180 SGTC_2993 9054257 71.4286 µM -0.0502421577364047 0.468205794558949 no 1798 0.479964708470369 568 6470217 YGL055W OLE1 SGTC_1801 st050089 28.441 µM -0.0517715952617837 0.467570443141773 no 1799 0.479355344443025 578 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2907 7721985 69.9 µM -0.0518391080007196 0.467542399223544 no 1800 0.479328446875003 577 3267881 SGTC_2759 disulfiram 3.38 µM -0.0531410368881649 0.467001626482112 no 1801 0.478809767459466 572 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2426 5582046 32.21 µM -0.053317227364299 0.466928448181048 no 1802 0.478739577136234 588 2251934 SGTC_513 4245-1575 41.7 µM -0.0541354900440742 0.46658860867461 no 1803 0.478413608363493 574 719745 SGTC_2312 7706453 155.7 µM -0.054203183522162 0.466560495418437 no 1804 0.478386642165705 579 976098 SGTC_1160 4092-0570 10.5 µM -0.0546570209975818 0.466372019993226 no 1805 0.4782058552113 569 4994975 SGTC_2893 9048488 25.97 µM -0.0550417103957584 0.466212267168476 no 1806 0.478052617024876 568 6467338 SGTC_337 1315-0038 354 µM -0.0553639773725901 0.466078441155841 no 1807 0.477924246846569 578 1626437 SGTC_1556 plumbagin 1.48 µM -0.0557623261483714 0.465913026380561 no 1808 0.47776557380053 571 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_66 0109-0187 42.4 µM -0.0559988805098154 0.46581479970199 no 1809 0.477671349493643 578 759417 SGTC_2822 7994718 71.43 µM -0.0560683321693809 0.465785961035434 no 1810 0.477643685753134 564 1018011 SGTC_954 1189-0853 2.85 µM -0.0566750534098177 0.465534037613211 no 1811 0.477402023280419 580 2828194 SGTC_1921 5740136 50 µM -0.0590550750910542 0.464545936847255 no 1812 0.476454120518554 574 1774243 SGTC_1365 1672-3266 55.4 µM -0.0593198387491305 0.464436029747695 no 1813 0.476348679950512 570 6415873 SGTC_3071 9117417 49.47 µM -0.0605484002460072 0.463926072319636 no 1814 0.475859434354852 583 45595590 YGL055W OLE1 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0615188747799656 0.463523284767446 no 1815 0.475472991487173 579 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2978 9011784 42.97 µM -0.0615631867471303 0.463504894335763 no 1816 0.475455347014043 575 2994934 SGTC_2734 clemastine 41.6 µM -0.0641715098384276 0.462422522161702 no 1817 0.47441683123967 582 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3325 9138760 55.175 µM -0.0656624148411181 0.461803967840199 no 1818 0.473823298208439 588 43844959 SGTC_1841 st054148 70 µM -0.0659499692595093 0.461684676367213 no 1819 0.473708828714433 606 675442 SGTC_2211 7117706 200 µM -0.0662672502813803 0.461553056862455 no 1820 0.473582528190968 565 822771 SGTC_3094 9117742 49.47 µM -0.0664786368425913 0.461465368500109 no 1821 0.473498382704529 579 17149698 SGTC_3257 9139206 32.98 µM -0.0667318155118828 0.461360346205816 no 1822 0.47339760281992 572 4910041 SGTC_2688 kanamycin b 96.69 µM -0.0684093312043978 0.460664556055254 no 1823 0.472729897003207 581 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_658 3253-0951 102 µM -0.0686734713199762 0.460555008481054 no 1824 0.472624767578724 585 1184878 SGTC_116 0155-0182 31.788 µM -0.0698817074680792 0.460053951591262 no 1825 0.472143906428099 581 771486 SGTC_587 k089-0003 57 µM -0.0708525218632443 0.459651399689326 no 1826 0.471757565209805 581 9659696 SGTC_293 4049-0273 38.5 µM -0.0712083895864773 0.459503848114498 no 1827 0.471615952222321 574 1380311 SGTC_1660 st012960 28.1 µM -0.0713381843345813 0.459450033383319 no 1828 0.471564302962366 581 24207266 SGTC_2549 cedrol 20.94 µM -0.0727860850467156 0.45884976394557 no 1829 0.470988172054257 580 6708665 A sedative which affects the nervous system. SGTC_713 1488-1073 324 µM -0.0730188050241817 0.458753291812199 no 1830 0.470895576604786 586 3312542 SGTC_1427 4048-4900 550 nM -0.0732612060944245 0.458652809045233 no 1831 0.470799130880881 579 24132586 SGTC_2213 7173844 200 µM -0.0734483592479267 0.458575230061459 no 1832 0.470724668183953 581 892728 SGTC_2481 5478948 45.16 µM -0.0736690827823507 0.458483737464935 no 1833 0.470636850142329 578 77792 SGTC_2899 9053889 58.44 µM -0.0739463064118606 0.458368828006577 no 1834 0.47052655474652 576 6470052 SGTC_3110 9122132 49.47 µM -0.0740286378713672 0.45833470220784 no 1835 0.470493799023938 578 918317 SGTC_1987 st072290 61.9 µM -0.0741762699544274 0.4582735105388 no 1836 0.470435063828277 595 54697379 SGTC_1369 1866-0067 208 µM -0.0744243213031119 0.458170698555861 no 1837 0.47033637843216 600 3531355 SGTC_408 cantharidin 100 µM -0.0760055066208105 0.457515397096883 no 1838 0.469707358611613 578 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2430 5571206 200 µM -0.0763399578827564 0.457376802907229 no 1839 0.469574318392168 577 1731771 SGTC_586 0957-0265 8.15 µM -0.0764278023418979 0.45734040165605 no 1840 0.469539375608946 585 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_603 3794-0023 45.9 µM -0.0772958352915683 0.456980722840891 no 1841 0.469194101976434 599 3802260 SGTC_1211 1056-0033 32.3 µM -0.0777459349362733 0.456794233053073 no 1842 0.469015076932639 585 6741922 SGTC_876 0720-0963 56.8 µM -0.0806062164623786 0.455609356655106 no 1843 0.467877561136736 588 765861 SGTC_2373 9071805 200 µM -0.0807736819727442 0.455539995917447 no 1844 0.46781096920311 629 10149009 SGTC_684 1140-0066 328 µM -0.0818646646741426 0.455088166797038 no 1845 0.467377166797622 602 6813534 SGTC_2029 5175081 200 µM -0.0822671948434627 0.454921474071387 no 1846 0.467217120345228 584 1380876 SGTC_2058 5236698 133 µM -0.0824326781926632 0.454852947668757 no 1847 0.467151325513483 592 766665 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.0827581737542303 0.454718164375027 no 1848 0.467021913749975 571 5711223 A potent inhibitor of glutathione S-transferases. SGTC_918 glabranin 770.725 nM -0.0829107754661708 0.45465497587159 no 1849 0.466961242980308 592 124049 Also referred to as licorice root. SGTC_1033 k072-0102 21.3 µM -0.083034579863288 0.454603712449778 no 1850 0.466912021894202 580 5965931 SGTC_1565 sinapyl alcohol 95.1 µM -0.0831332371476927 0.4545628621804 no 1851 0.466872798942851 582 5280507 A phenol propionate derived from cinnamic acid. SGTC_332 4112-0506 40.9 µM -0.0833958517913608 0.454454125680927 no 1852 0.466768393407334 579 2790355 SGTC_254 nsc-64875 3.808 µM -0.0839840372211757 0.454210597869138 no 1853 0.466534561689032 606 56993 SGTC_1626 st003712 1.76 µM -0.0846488189278923 0.453935377444042 no 1854 0.466270293212045 613 24207035 SGTC_2171 5739187 198.077 µM -0.0855794800857766 0.453550119792652 no 1855 0.465900355562105 580 2262761 SGTC_1023 4482-3888 16 µM -0.086258912837312 0.453268888546905 no 1856 0.465630299748507 582 3303168 SGTC_711 k292-0785 179 µM -0.0864270894997679 0.453199280366463 no 1857 0.465563456593978 591 4146315 SGTC_3014 9081533 49.47 µM -0.0866965153254483 0.453087768239739 no 1858 0.465456373178564 593 21367265 SGTC_143 4032-1194 15.74 µM -0.0868688704463467 0.45301643445631 no 1859 0.465387871869713 585 1806963 SGTC_3172 9105863 49.47 µM -0.0870130693999605 0.452956755021654 no 1860 0.465330561815865 589 2348785 SGTC_2852 9023854 51.95 µM -0.0892360340370568 0.452036874783298 no 1861 0.464447164288389 588 19798528 SGTC_1057 3448-5381 134 µM -0.0893834436232199 0.451975884584999 no 1862 0.464388590437652 602 5497911 SGTC_3278 9139605 49.47 µM -0.0897084723583265 0.451841409094506 no 1863 0.464259441561546 622 7958859 SGTC_2823 7987624 58.44 µM -0.0901756008557198 0.451648151759086 no 1864 0.464073836508092 597 2239440 SGTC_113 0099-0221 2.5 µM -0.0906348880402635 0.45145814965109 no 1865 0.463891354680585 585 89219 SGTC_339 3091-4833 71.4 µM -0.0931887433720146 0.450401851518989 no 1866 0.462876808480898 588 3240077 SGTC_2768 sulfasalazine 50.2 µM -0.0932643928350895 0.450370567522319 no 1867 0.462846759576147 608 5384001 An antioxidant and salicylic acid derivative. SGTC_1678 st019265 80.2 µM -0.0945499485544089 0.449838987510235 no 1868 0.462336153456253 616 5367020 SGTC_2067 5224629 34.075 µM -0.0946102534481337 0.449814053511416 no 1869 0.462312202649081 599 2835000 SGTC_1150 3909-7983 10.9 µM -0.0949134338220082 0.449688701861377 no 1870 0.462191793022918 583 23965914 SGTC_508 roscovitine 141 µM -0.0962467132624764 0.449137509640827 no 1871 0.461662315587555 589 160355 A CDKinase inhibitor. SGTC_3285 9112818 20.8695 µM -0.0976973187903215 0.448537925046682 no 1872 0.461086322334231 586 17017947 YPR165W RHO1 SGTC_1225 1216-0074 20.6 µM -0.0987178277286353 0.448116184340598 no 1873 0.460681156763142 584 4241466 SGTC_2190 6049624 200 µM -0.10017118614734 0.447515663391708 no 1874 0.460104210527649 592 2265554 SGTC_165 k038-0023 64.381 µM -0.100494774371034 0.447381974564815 no 1875 0.459975765642628 594 46368543 SGTC_111 0083-0039 52.457 µM -0.103797665143952 0.446017746605816 no 1876 0.458664959703571 587 759313 SGTC_2020 4017018 200 µM -0.104256431768532 0.445828307528631 no 1877 0.458482925922107 597 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_481 bay k-8644 50 µM -0.104293898646672 0.445812836829314 no 1878 0.458468059842151 641 2303 A calcium channel antagonist. SGTC_2418 pentamidine 31.67 µM -0.104835347851873 0.44558927263836 no 1879 0.458253230526389 604 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_405 ebelactone b 50 µM -0.105547935617402 0.445295071772594 no 1880 0.457970517627999 582 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1701 st028638 40.4 µM -0.106672030035422 0.444831036489707 no 1881 0.457524586383762 603 3490878 SGTC_266 formosanin C 406 nM -0.106762669403977 0.444793623109011 no 1882 0.45748863182731 604 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2536 dehydroabietamide 32.04 µM -0.108240951728372 0.444183499423076 no 1883 0.456902280491971 605 3983547 SGTC_2783 7738165 71.43 µM -0.108486611090191 0.444082122503171 no 1884 0.456804850315954 602 17201110 SGTC_1490 4089-0339 670 nM -0.10888333444655 0.443918413319875 no 1885 0.456647512615905 602 742542 SGTC_427 1354-0053 47.3 µM -0.109250103654636 0.443767073325433 no 1886 0.456502060566332 639 6813657 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.111287053628626 0.442926716411784 no 1887 0.455694360670441 626 165506 SGTC_2766 oltipraz 83.91 µM -0.111803601809513 0.442713651761518 no 1888 0.455489565800573 591 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1664 st014217 9.02 µM -0.111839761601536 0.442698737270279 no 1889 0.455475230039263 609 3982782 SGTC_2731 amoxapine 43.43 µM -0.11255040184502 0.442405642640921 no 1890 0.455193504341968 583 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2939 9044578 71.43 µM -0.112587091995484 0.442390511104255 no 1891 0.455178959536103 599 2653634 SGTC_1881 5652484 16 µM -0.113645514058079 0.441954039154761 no 1892 0.454759403024129 640 2255129 SGTC_197 4544-0043 41.561 µM -0.11460667893849 0.441557735144195 no 1893 0.454378442784476 598 896523 SGTC_1461 k072-0203 53.8 µM -0.116664144043998 0.440709605748485 no 1894 0.453563102550337 600 5418714 SGTC_2437 5741531 144.16 µM -0.117197193762983 0.440489915891677 no 1895 0.453351895324252 604 2262990 SGTC_407 eburnamonine 100 µM -0.11767518204149 0.44029293450164 no 1896 0.45316251599466 602 3195 SGTC_843 0310-0051 143 µM -0.117864533454355 0.44021490590895 no 1897 0.453087497760089 599 2065037 SGTC_3222 9128301 49.47 µM -0.118562845674292 0.439927163059305 no 1898 0.452810851260113 591 4911358 SGTC_777 1315-0167 517 µM -0.118612063931954 0.439906883638837 no 1899 0.452791353596965 593 4221767 SGTC_1415 3966-0071 78.1 µM -0.118676322402975 0.439880407429908 no 1900 0.452765897970338 609 2893185 SGTC_1152 3909-8331 15.9 µM -0.119220784488368 0.439656085288396 no 1901 0.452550220222955 606 16001939 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.119799215680013 0.439417788865529 no 1902 0.452321101632937 604 1377 SGTC_1677 st019204 53.9 µM -0.120030321090465 0.439322586451992 no 1903 0.452229564417333 607 3945625 SGTC_3236 9132701 49.47 µM -0.120814600100975 0.438999533864362 no 1904 0.451918942803757 621 24282524 SGTC_1009 4106-0057 9.87 µM -0.121624428642888 0.438665999799284 no 1905 0.451598232927184 598 2928005 SGTC_2110 5483698 200 µM -0.121877145671155 0.438561925267596 no 1906 0.451498157894196 592 2848765 YHR062C RPP1 SGTC_3293 9120939 62.045 µM -0.122699353570124 0.438223351073386 no 1907 0.45117258788759 612 934087 SGTC_2108 5365811 200 µM -0.122849083567028 0.438161699126428 no 1908 0.451113302766644 588 780283 SGTC_3003 9075612 71.4286 µM -0.12341082384762 0.437930413626635 no 1909 0.450890893201544 632 6501993 SGTC_429 1112-0049 25.5 µM -0.124566476311894 0.437454663242265 no 1910 0.450433384828209 596 2836170 SGTC_922 1866-0035 480 µM -0.125917955544287 0.436898411093333 no 1911 0.449898434667598 634 3156169 SGTC_1008 4106-0037 6 µM -0.126086086006716 0.436829219374521 no 1912 0.449831890663065 608 2905394 SGTC_2478 5763493 32.33 µM -0.126232624610445 0.436768915056471 no 1913 0.449773893605659 595 1365576 YLR208W SEC13 SGTC_2810 7959871 45.46 µM -0.127907081454454 0.436079938647062 no 1914 0.44911125344581 614 2974535 SGTC_1336 1486-0901 104 µM -0.129235084295963 0.435533652888703 no 1915 0.44858581786172 597 5006114 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.129310064851946 0.435502812629938 no 1916 0.448556153849727 589 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_708 3448-5400 146 µM -0.129754435406998 0.435320046597114 no 1917 0.448380356667892 597 3462195 SGTC_984 1492-0255 2.91 µM -0.130564650278669 0.434986847328437 no 1918 0.448059854137084 613 1585198 SGTC_1486 3970-0793 4.53 µM -0.131567139684402 0.434574639456086 no 1919 0.447663339132674 624 2844330 SGTC_2306 7482397 179.52 µM -0.132408668797214 0.43422867080705 no 1920 0.447330529170228 632 891448 SGTC_3335 9143315 29.6265 µM -0.134224977436746 0.433482123745573 no 1921 0.44661233774352 605 4899691 SGTC_2854 9024559 71.43 µM -0.135544241558705 0.432940022679278 no 1922 0.446090793638932 635 3163529 SGTC_294 k038-0071 157 µM -0.135715628566571 0.432869606990965 no 1923 0.446023046113835 605 24152826 SGTC_2657 nystatin 74.44 µM -0.1358657353933 0.432807936181892 no 1924 0.4459637117203 610 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1453 4237-0541 195 µM -0.1372466468822 0.432240671007701 no 1925 0.445417920429453 599 739892 SGTC_726 3448-4391 34.2 µM -0.137515747170389 0.432130143417179 no 1926 0.44531157327383 630 1356692 SGTC_287 k060-0039 29.6 µM -0.138391146836559 0.43177062720653 no 1927 0.444965646747066 616 5861974 SGTC_2651 TUB2.036 5 µM -0.138465630016988 0.431740040456122 no 1928 0.444936215598426 601 15992207 YFL037W TUB2 SGTC_2495 cafestol 54.53 µM -0.140761272351855 0.430797529319628 no 1929 0.444029269280979 649 16667697 An anti-infammatory. SGTC_3044 9093193 49.47 µM -0.141782382966246 0.430378422998902 no 1930 0.443625949918381 644 25236277 SGTC_2956 9076196 2.52 µM -0.142687415707688 0.430007025406634 no 1931 0.443268527913025 637 16423868 SGTC_480 am 92016 50 µM -0.14488456273894 0.429105642137249 no 1932 0.442401007486254 661 2129 K+ channel blocker. SGTC_2316 5844804 197.44 µM -0.145111211228924 0.429012680160994 no 1933 0.44231153335152 639 776813 SGTC_2283 7944793 200 µM -0.147829167778167 0.427898193285076 no 1934 0.441238794838677 596 2970533 SGTC_3034 9090421 49.47 µM -0.148424279437555 0.427654246623683 no 1935 0.441003970030263 612 17173761 SGTC_2824 7998404 51.95 µM -0.149226600229578 0.427325405110252 no 1936 0.440687415520738 599 837851 SGTC_1388 3346-4487 254 µM -0.149513551921173 0.427207806508276 no 1937 0.440574208335991 639 3345614 SGTC_746 1095-0025 46.6 µM -0.149560686355196 0.427188490482937 no 1938 0.440555613486953 615 6749286 SGTC_3033 9090887 49.47 µM -0.150965178782558 0.42661299982384 no 1939 0.440001592168572 608 19325384 SGTC_2239 6685329 187.64 µM -0.151076798666831 0.426567270269357 no 1940 0.439957567197146 630 805680 SGTC_131 0141-0277 33.849 µM -0.151169169903523 0.426529427440439 no 1941 0.439921134813955 636 1547771 SGTC_3243 9134147 49.47 µM -0.151724453560917 0.426301952011495 no 1942 0.439702134653292 627 24282180 SGTC_1564 D-Arginine 115 µM -0.151747247005754 0.42629261505734 no 1943 0.439693145464858 652 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_153 4077-0274 519.67 µM -0.152131223622856 0.426135331660492 no 1944 0.439541718965731 597 3121976 SGTC_661 1304-0007 33.6 µM -0.153428240297881 0.425604138433265 no 1945 0.43903028799795 612 3117130 SGTC_224 benfluorex 43.875 µM -0.153889780410241 0.425415147179315 no 1946 0.438848321083845 615 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2250 alverine citrate 130 µM -0.154576025156761 0.425134175658588 no 1947 0.438577785972653 601 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_764 1951-2361 146 µM -0.155031108891841 0.424947870136312 no 1948 0.438398396221173 621 5438930 SGTC_2540 epiandrosterone 100 µM -0.155163298411698 0.424893756559425 no 1949 0.438346290719362 612 441302 A steroid. SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.155303339921776 0.424836430207479 no 1950 0.438291091343105 614 4330530 SGTC_2873 9040596 71.43 µM -0.155672580028515 0.424685288445048 no 1951 0.438145555800391 631 6463863 SGTC_845 0330-0138 4.51 µM -0.156162752675071 0.424484662242917 no 1952 0.437952367769752 611 9039800 SGTC_2401 5128683 200 µM -0.156181145677288 0.42447713442247 no 1953 0.437945118962735 655 708373 SGTC_98 0074-0023 107.663 µM -0.156703808969677 0.424263232232353 no 1954 0.437739142523898 661 3563821 SGTC_2546 rhodinyl acetate 100 µM -0.156855492412038 0.424201159307575 no 1955 0.437679368733958 636 6708682 SGTC_3148 9097893 49.47 µM -0.157976348923849 0.423742533200042 no 1956 0.437237717748536 606 17174100 SGTC_724 3910-0327 137 µM -0.158251590357721 0.423629927144132 no 1957 0.437129276330214 628 2885483 SGTC_51 1013-0126 23.419 µM -0.15895288011484 0.423343045520822 no 1958 0.436852998977527 605 1627850 SGTC_636 0kpi-0074 126 µM -0.159592213408242 0.423081544276026 no 1959 0.436601156580702 619 616434 SGTC_251 melphalan 456.522 µM -0.16112452117233 0.422454935157018 no 1960 0.435997663733049 630 460612 A DNA alkylator. SGTC_1904 st060225 78 µM -0.161423670291606 0.422332626459259 no 1961 0.435879862472499 608 66595 SGTC_908 3448-7491 47.7 µM -0.161553529471293 0.422279535177976 no 1962 0.435828727287489 610 1203031 SGTC_1348 1493-0373 93.8 µM -0.162637086316031 0.42183659182233 no 1963 0.435402092538524 647 3010129 SGTC_2177 5811945 192 µM -0.163188086350114 0.421611388358958 no 1964 0.435185173092076 601 5343475 SGTC_770 0389-1121 67.2 µM -0.163948492486409 0.421300639033056 no 1965 0.434885846029271 614 6753108 SGTC_1725 st036284 20.55 µM -0.164505307037383 0.421073120989032 no 1966 0.434666684626172 632 707914 SGTC_2958 9077254 16.72 µM -0.164690217165005 0.420997571334859 no 1967 0.434593908703776 624 16457351 SGTC_2589 lobaric acid 100 µM -0.164968899776334 0.420883714085821 no 1968 0.434484230505016 623 73157 A novel microtubule depolymerizer. SGTC_95 0471-0001 561.058 µM -0.165457815509654 0.42068398098075 no 1969 0.434291825244299 616 4015405 SGTC_21 0849-0113 22.993 µM -0.166880089837714 0.420103066102694 no 1970 0.433732199731303 612 1560156 SGTC_26 0302-0163 425.158 µM -0.167193656004438 0.419975016251147 no 1971 0.433608837968418 644 3100915 SGTC_1789 tunicamycin 25 nM -0.167677961910605 0.419777258696331 no 1972 0.433418317272846 635 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_566 0958-0068 16.5 µM -0.170475696749931 0.418635252300295 no 1973 0.432318022887884 659 6815365 SGTC_1198 1612-1005 86.7 µM -0.174557069972611 0.416970509682549 no 1974 0.430713841884476 622 6998509 SGTC_58 0957-0393 9 µM -0.174611591345675 0.416948281079281 no 1975 0.430692419970546 632 6997992 SGTC_1953 st076800 12.1 µM -0.175369324437039 0.416639377486752 no 1976 0.430394721296252 620 297591 SGTC_1876 myriocin 605 nM -0.175834486839816 0.41644977110815 no 1977 0.43021198757075 633 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_509 pifithrin 175 µM -0.176710509216225 0.416092745552555 no 1978 0.429867892814559 615 4817 A p53 inhibitor. SGTC_3194 9111903 49.47 µM -0.178919029650121 0.415192964313515 no 1979 0.429000640194241 643 17087251 SGTC_1640 st009078 66.4 µM -0.179197154390593 0.415079683938678 no 1980 0.428891449015061 642 690618 SGTC_941 3237-0776 460 µM -0.179338226946238 0.415022227699541 no 1981 0.428836066310631 618 760008 SGTC_600 1495-0418 41.6 µM -0.179737854201062 0.4148594767907 no 1982 0.428679187004954 634 5377768 SGTC_3331 9141060 1.957 µM -0.180106473761012 0.414709366930391 no 1983 0.428534490196352 634 4906567 YPR165W RHO1 SGTC_479 n-linoleoylglycine 10 µM -0.180246832520273 0.414652213079391 no 1984 0.42847939671718 640 6433346 An anti-infammatory. SGTC_1291 0993-0025 5.79 µM -0.180321917040263 0.414621639530675 no 1985 0.428449925188999 635 4353356 SGTC_3292 9120825 59.784 µM -0.181262703260398 0.414238606153512 no 1986 0.428080689770364 627 24824900 SGTC_841 0251-0215 91.2 µM -0.181367918543428 0.41419577367958 no 1987 0.428039399271943 655 3888614 SGTC_1482 3346-2049 8.48 µM -0.181928971449734 0.413967389844308 no 1988 0.427819233981699 641 3826804 SGTC_1909 st060837 51.5 µM -0.182814173592973 0.413607116063802 no 1989 0.427471913556519 651 678937 SGTC_2433 5607874 27.82 µM -0.182892875844333 0.413575088073495 no 1990 0.427441036434478 617 2252428 SGTC_354 2783-3500 4.88 µM -0.183134596668191 0.413476723044976 no 1991 0.427346205289349 626 6740761 SGTC_2726 cimetidine 79.27 µM -0.183817364314008 0.413198909311507 no 1992 0.427078366749543 639 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_736 0958-0254 92.6 µM -0.185896965714498 0.412353001294772 no 1993 0.426262780868861 652 6812352 SGTC_3097 9117246 49.47 µM -0.187131052874914 0.411851210613317 no 1994 0.425778940758274 620 16423892 SGTC_3154 9100113 49.47 µM -0.189192900400261 0.411013167196103 no 1995 0.424970815921117 642 25237525 SGTC_2037 5169046 200 µM -0.190603953060897 0.410439874829793 no 1996 0.424417946440409 643 5718022 SGTC_14 0354-0009 295 µM -0.191016360628101 0.41027235506732 no 1997 0.424256387617781 633 1713507 SGTC_1331 1472-0049 76.2 µM -0.191231634473958 0.410184917432365 no 1998 0.42417206010384 627 24051409 SGTC_2654 protoveratrine a 100 µM -0.191751305478897 0.409973861412498 no 1999 0.423968507820401 642 5702278 A heart drug and vasodilator. SGTC_657 3534-0529 86.7 µM -0.193666940176992 0.409196082894007 no 2000 0.423218339807758 651 1049549 SGTC_3118 9124250 49.47 µM -0.196818330161732 0.407917346625865 no 2001 0.421984853143065 626 1504786 SGTC_545 4218-0007 221 µM -0.196882616785242 0.407891271265198 no 2002 0.421959698613325 655 2840508 SGTC_56 0957-0365 83.25 µM -0.197259904311427 0.407738247526991 no 2003 0.421812077272697 623 6752360 SGTC_3082 9117008 49.47 µM -0.198009701468653 0.407434179714121 no 2004 0.421518736670256 624 41448529 SGTC_2749 bexarotene 57.39 µM -0.198149593877603 0.407377454832989 no 2005 0.421464011852553 644 82146 An retinoic acid receptor inhibitor. SGTC_3217 9129673 49.47 µM -0.200975085166135 0.406232165572633 no 2006 0.420359027868664 656 17248312 SGTC_748 act1.228 77.9 µM -0.201401291045762 0.406059475944046 no 2007 0.420192402893232 636 4421505 YNR035C ARC35 SGTC_2297 7971671 152.32 µM -0.201424721958687 0.406049982762236 no 2008 0.420183243004029 648 909016 SGTC_2512 diallyl trisulfide 49.23 µM -0.201847360937817 0.405878757409989 no 2009 0.420018027410172 634 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2560 caryophyllene 100 µM -0.202464939948426 0.405628587638254 no 2010 0.419776632334433 628 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1347 1493-0251 600 nM -0.202915565985867 0.405446071726059 no 2011 0.419600513740088 641 3986378 SGTC_930 2810-3379 265 µM -0.202919536370143 0.405444463702771 no 2012 0.419598962062617 669 1015764 SGTC_653 0203-0016 55.2 µM -0.203083307659334 0.405378136993211 no 2013 0.419534959216468 655 295302 SGTC_3213 9129884 49.47 µM -0.203676834166375 0.405137783940042 no 2014 0.419303023186349 660 17190742 SGTC_2303 7774051 200 µM -0.204826311537837 0.404672396186214 no 2015 0.418853914590539 659 2953184 SGTC_675 1309-0189 238 µM -0.205268299299714 0.404493484893903 no 2016 0.418681255089336 625 4246530 SGTC_1518 st038567 90.8 µM -0.206135097409333 0.404142673531853 no 2017 0.418342691838461 643 77966 SGTC_2270 7924575 90.91 µM -0.207595972286838 0.403551601394042 no 2018 0.417772224753066 661 1262135 SGTC_486 niguldipine 82 µM -0.208040915693412 0.403371620322519 no 2019 0.417598510052098 616 1236 A calcium channel blocker. SGTC_316 k060-0003 58.6 µM -0.208800814357927 0.403064286153072 no 2020 0.417301867791354 653 6152314 SGTC_1990 st072050 59.8 µM -0.209594871684055 0.402743200792872 no 2021 0.416991941273343 635 17233948 SGTC_3280 9140961 49.47 µM -0.210626811681018 0.402326023122003 no 2022 0.416589244464526 651 4901226 SGTC_811 0416-0114 265 µM -0.211405249028778 0.402011401377289 no 2023 0.416285530585735 631 6612453 SGTC_1372 2752-0194 270 µM -0.212066156193932 0.401744331736836 no 2024 0.416027711317312 652 823334 SGTC_188 3229-0966 278.469 µM -0.212713302514466 0.401482867248336 no 2025 0.415775295152563 639 5722370 SGTC_1063 disulfiram 1.84 µM -0.213117932270176 0.401319408363797 no 2026 0.415617489000237 625 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1130 3454-2858 15.9 µM -0.213389913589963 0.401209545368337 no 2027 0.415511423563356 650 715628 YIL048W NEO1 SGTC_2912 7964298 10.93 µM -0.213729730436126 0.401072292150761 no 2028 0.415378912737306 626 2975850 SGTC_383 2324-0395 7.37 µM -0.214026676847294 0.400952364447278 no 2029 0.415263127021062 662 3146421 SGTC_43 0570-0105 72.5 µM -0.214979342448419 0.400567674587833 no 2030 0.414891712178668 644 1114046 YDL195W SEC31 SGTC_1014 4130-3005 69.3 µM -0.215504260606661 0.400355751890341 no 2031 0.414687095309287 658 743608 SGTC_1239 0337-0584 35.4 µM -0.216074692767523 0.400125487302489 no 2032 0.414464762999129 664 914301 YML130C ERO1 SGTC_150 3970-0969 77.2 µM -0.216321543703415 0.400025852505821 no 2033 0.414368558578678 642 6615640 SGTC_215 1287-0124 461.5 µM -0.216685641923847 0.399878905849455 no 2034 0.414226669129671 653 5560863 SGTC_2352 9027995 87.8 µM -0.217086816886345 0.399717011781827 no 2035 0.41407034379884 646 2997347 SGTC_2188 6126565 140.678 µM -0.217767547195806 0.399442342671862 no 2036 0.413805115657848 667 874518 SGTC_3147 9097027 49.47 µM -0.217948206778529 0.399369456358973 no 2037 0.413734733137615 638 25236841 SGTC_406 estrone 100 µM -0.21850692862866 0.399144064697381 no 2038 0.413517080239512 668 5870 A steroid. SGTC_441 propafenone 146 µM -0.218745266527671 0.399047928020274 no 2039 0.413424242596839 631 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_378 3970-0959 8.33 µM -0.218761784819795 0.399041265380125 no 2040 0.413417808552664 678 6615653 SGTC_225 nsc-122657 1.016 µM -0.219095556664675 0.398906645073039 no 2041 0.413287805979824 674 275685 SGTC_3328 9140624 29.0385 µM -0.219756172871563 0.398640233989519 no 2042 0.413030527097787 651 4904392 SGTC_2411 st077133 39.94 µM -0.219770766041852 0.398634349437526 no 2043 0.413024844166868 696 1403142 YNL221C POP1 SGTC_247 mechlorethamine 29.705 µM -0.220063483326369 0.398516318948375 no 2044 0.412910856878518 639 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2456 5770359 74.46 µM -0.222231646551368 0.397642354272856 no 2045 0.412066779808366 639 3118787 SGTC_2839 9003951 25.97 µM -0.222980480808104 0.397340625834254 no 2046 0.411775349065794 651 2990634 SGTC_644 1498-1197 63.3 µM -0.223293290977515 0.397214603137879 no 2047 0.411653624242907 647 6741615 SGTC_1292 0kpi-0043 232 µM -0.223637909154944 0.397075778284298 no 2048 0.411519531711176 670 3333905 SGTC_3011 9081274 71.4286 µM -0.223959530296031 0.396946229244724 no 2049 0.411394396755341 629 6625322 SGTC_626 0214-0009 33 µM -0.22412864103354 0.396878115977212 no 2050 0.411328603499295 669 3437874 SGTC_1026 k007-1105 30.6 µM -0.226083303254424 0.396091059309705 no 2051 0.410568315242391 609 7066794 SGTC_1204 4049-0315 18.3 µM -0.226532454968679 0.395910265335898 no 2052 0.410393659900845 649 588402 SGTC_1202 1988-0068 29.6 µM -0.227981934995757 0.395326968938266 no 2053 0.409830142261302 646 2850480 SGTC_1386 3228-0095 33.8 µM -0.228685655497616 0.395043863819202 no 2054 0.409556622314966 681 870181 SGTC_3343 9148379 18.9835 µM -0.230405855164503 0.394352065002562 no 2055 0.408888205888935 650 1955036 SGTC_2964 9083345 53.42 µM -0.230738765645822 0.394218219485957 no 2056 0.40875887769711 633 17741579 SGTC_186 3455-3465 67.277 µM -0.232724537047306 0.393420106882271 no 2057 0.407987657243159 640 755278 SGTC_1257 0669-0121 16 µM -0.233012761673749 0.393304302016705 no 2058 0.407875748058776 636 4307855 SGTC_311 1315-0136 58 µM -0.234258647543115 0.392803830165945 no 2059 0.407392093620145 656 6759207 SGTC_2233 sulbentine 40.3845 µM -0.234750379522939 0.392606350343948 no 2060 0.407201241462335 650 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2121 5257820 149.641 µM -0.234790233904287 0.392590346013879 no 2061 0.407185774051813 644 791256 SGTC_1635 st007035 42.4 µM -0.235098282302585 0.392466649100321 no 2062 0.407066225931733 656 3716403 SGTC_1141 3253-0389 52.6 µM -0.235222757689947 0.392416669057355 no 2063 0.407017921696848 645 5402031 SGTC_2057 5236571 38.335 µM -0.235310664509904 0.392381373295955 no 2064 0.406983809205133 652 54684039 YBR257W POP4 SGTC_2368 9071271 200 µM -0.235427836500314 0.392334328554487 no 2065 0.406938341377852 671 27209959 SGTC_2016 5121758 140 µM -0.237380146298441 0.391550705069468 no 2066 0.406180945285835 677 2795203 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.238373712640904 0.391152073363059 no 2067 0.405795627062315 665 551469 SGTC_2718 lomofungin 53.02 µM -0.239170664339443 0.390832408603414 no 2068 0.405486624541234 666 5351222 A RNA synthesis inhibitor. SGTC_159 3970-0959 50 µM -0.239403664280573 0.390738964077921 no 2069 0.405396294463468 639 6615653 SGTC_2372 9071633 200 µM -0.23949835501687 0.390700990201877 no 2070 0.405359585930012 622 21321366 SGTC_996 3970-0799 1.8 µM -0.240372317727809 0.390350553726275 no 2071 0.405020818215735 652 6615648 YGL040C HEM2 SGTC_1098 clofazimine 15.1 µM -0.240380588794709 0.390347237667075 no 2072 0.405017612502652 642 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3068 9116768 49.47 µM -0.241682132296743 0.389825518762728 no 2073 0.404513237779394 663 41904888 SGTC_3268 9137683 49.47 µM -0.241940235613796 0.389722082549637 no 2074 0.404413236288152 667 1953228 SGTC_989 1501-0895 10.3 µM -0.242541271063061 0.389481244826915 no 2075 0.404180390803417 661 2830112 SGTC_1345 1488-0192 31.4 µM -0.242586598247788 0.389463083731329 no 2076 0.404162832099225 680 658348 SGTC_2772 vinpocetine 57.06 µM -0.243032204573438 0.389284556953163 no 2077 0.403990224787394 644 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2938 9059746 27.26 µM -0.245760121182556 0.38819216090047 no 2078 0.402933964537117 675 6471769 SGTC_2074 5212007 75.395 µM -0.246333196098315 0.38796278473409 no 2079 0.402712157361525 636 758611 SGTC_2572 astragaloside iv 100 µM -0.246851391869506 0.387755407872266 no 2080 0.40251161797197 653 45006101 An anti-inflammatory agent. SGTC_2679 rapamycin 1 nM -0.247224140641834 0.38760625726397 no 2081 0.402367381763475 668 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1448 4255-0083 152 µM -0.247280855949769 0.387583564818968 no 2082 0.402345436776639 704 5399660 SGTC_1287 0971-0001 34.6 µM -0.248466837635635 0.387109128035475 no 2083 0.401886612715584 638 4665869 SGTC_1374 2889-5571 141 µM -0.249364232163406 0.386750248859036 no 2084 0.401539524990091 636 2853281 SGTC_129 0088-0017 176.636 µM -0.249887870363959 0.386540884172734 no 2085 0.401337031879897 689 182446 SGTC_1466 k213-0079 57.5 µM -0.251602140519838 0.385855704005656 no 2086 0.400674301972888 672 3657981 SGTC_1804 st050076 49.1 µM -0.252437246657682 0.385522047516867 no 2087 0.400351556725398 650 3895976 SGTC_12 0849-0099 9.267 µM -0.253029991989977 0.385285274717306 no 2088 0.400122518442874 639 6071388 SGTC_1044 1222-0021 1.78 µM -0.25602474391933 0.38408967302609 no 2089 0.39896586551573 676 4306703 SGTC_3215 9129942 49.47 µM -0.256312761365006 0.383974745080056 no 2090 0.398854672085187 688 17682944 SGTC_2281 7943571 200 µM -0.25701665382809 0.383693912983784 no 2091 0.398582958462295 668 1244024 SGTC_890 0929-0006 47.2 µM -0.257081581605292 0.383668011812036 no 2092 0.398557897787549 666 1378169 SGTC_1055 3448-0672 86 µM -0.25745904280116 0.383517444226545 no 2093 0.398412214467454 689 748378 SGTC_2989 9073649 71.4286 µM -0.257596261072507 0.383462712828871 no 2094 0.398359257793864 694 21367202 SGTC_1502 4534-4282 27.7 µM -0.259128599453884 0.38285167677324 no 2095 0.397768009529486 696 3278949 SGTC_2875 9039966 71.43 µM -0.261047482022864 0.382086913282234 no 2096 0.397027945484628 677 6463691 SGTC_493 zm226600 134 µM -0.261867207966872 0.381760354562644 no 2097 0.396711910935954 702 5240098 A potassium channel opener. YCR052W RSC6 SGTC_81 0411-0046 9.971 µM -0.261928414448648 0.381735974773316 no 2098 0.396688316301556 671 12925265 SGTC_3339 9145883 14.936 µM -0.262055391384951 0.381685398767426 no 2099 0.396639368862325 683 2030670 SGTC_2268 7933382 153.85 µM -0.263709202922948 0.381026856166753 no 2100 0.396002001793658 644 935025 YOR257W CDC31 SGTC_1053 3366-3204 134 µM -0.26409836722707 0.380871942144723 no 2101 0.395852061003017 662 3632071 YPR165W RHO1 SGTC_829 1635-0120 117 µM -0.264783135508628 0.380599403884536 no 2102 0.395588264627924 666 285054 SGTC_3348 9149464 3.537 µM -0.264939036885964 0.380537363301093 no 2103 0.395528212716466 655 1951442 SGTC_3025 9087895 49.47 µM -0.266185197664716 0.38004156712784 no 2104 0.395048291232944 653 17173641 SGTC_3208 9114115 49.47 µM -0.266345828773366 0.379977672931234 no 2105 0.3949864405408 705 650895 SGTC_2992 9074591 71.4286 µM -0.26732820093976 0.379586986335904 no 2106 0.394608237703641 664 17741321 SGTC_527 4476-4215 268 µM -0.267527214674189 0.379507854102424 no 2107 0.3945316316184 645 4418754 SGTC_2172 5754775 163.918 µM -0.268139728230307 0.379264336937823 no 2108 0.394295883216504 657 2263357 SGTC_2349 9023730 187.07 µM -0.269136524244866 0.378868142940557 no 2109 0.39391231236373 684 4126287 SGTC_496 calpeptin 138 µM -0.269553090969005 0.378702608890861 no 2110 0.393752046385626 653 73364 A calpain inhibitor. SGTC_3037 9091026 49.47 µM -0.270272044104692 0.37841696578061 no 2111 0.393475485437051 679 25236398 YIL048W NEO1 SGTC_3126 9127922 49.47 µM -0.270617616427018 0.378279692068084 no 2112 0.393342572645978 718 45595682 SGTC_824 1304-0008 100 µM -0.272419985798023 0.377563975725551 no 2113 0.392649553582621 657 768245 SGTC_1037 k284-1091 78.7 µM -0.272485790180587 0.377537852907267 no 2114 0.3926242579282 661 3334711 SGTC_413 propylparaben 100 µM -0.273577683163785 0.377104478492272 no 2115 0.392204593082211 674 7175 A pharmaceutical preservative. SGTC_820 1582-0060 59.9 µM -0.274493568466017 0.376741081182744 no 2116 0.391852672752726 669 3848840 SGTC_3282 9108498 15.4605 µM -0.275068001938214 0.376513217967102 no 2117 0.391631997207089 683 16459645 SGTC_1749 st037932 54.2 µM -0.275367493505593 0.376394434301951 no 2118 0.391516957733219 689 594497 SGTC_2850 9015429 58.44 µM -0.27549148509808 0.37634526046363 no 2119 0.391469333367021 649 6457570 SGTC_712 r015-0009 80.6 µM -0.275775895354328 0.376232473753832 no 2120 0.391360099379259 661 6813872 YLR060W FRS1 SGTC_2607 solasodine 47.35 µM -0.276628666277747 0.375894359369384 no 2121 0.391032625417366 660 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1560 lithocholic acid 53.1 µM -0.276786530913378 0.375831778202334 no 2122 0.390972012026043 654 9903 A bile acid which acts as a detergent. SGTC_2124 5246320 200 µM -0.278549667999318 0.375133052451177 no 2123 0.390295221711789 678 579342 SGTC_455 paf C-16 10 µM -0.279127991382305 0.374903953778392 no 2124 0.390073301234825 668 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1808 st050063 61.5 µM -0.279227419964296 0.374864570300723 no 2125 0.39003515103528 704 4011993 SGTC_2322 7413319 38.22 µM -0.282497619503522 0.373569979823389 no 2126 0.388780985821353 677 1840400 SGTC_2017 5132927 60.65 µM -0.283000386637462 0.373371072905562 no 2127 0.388588270310147 683 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1634 st006576 41 µM -0.28530710490575 0.372458912208644 no 2128 0.387704435023715 686 3915356 SGTC_2338 7999974 200 µM -0.285502533907187 0.372381665221569 no 2129 0.387629581689189 695 315925 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.285630280343604 0.372331173815476 no 2130 0.387580654428793 673 442882 SGTC_471 1-acyl-paf 4 µM -0.286505152515754 0.371985442163372 no 2131 0.38724562383412 657 16759367 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.286796391403948 0.371870373369776 no 2132 0.387134113085878 658 5355888 SGTC_3173 9105693 49.47 µM -0.287306121852141 0.371669005878072 no 2133 0.38693896780761 718 17096658 SGTC_2448 5185112 27.17 µM -0.287700206753608 0.371513347875215 no 2134 0.386788115871807 652 5718189 SGTC_1036 k216-0215 33.5 µM -0.287862874485856 0.371449102529086 no 2135 0.386725853203219 670 622330 SGTC_641 4092-0595 30 µM -0.287876961829321 0.371443538925044 no 2136 0.386720461271611 663 786260 SGTC_1833 st055984 71 µM -0.287906516144109 0.371431866939048 no 2137 0.386709149426803 661 676288 SGTC_3189 9110682 49.47 µM -0.288588618014873 0.371162515000221 no 2138 0.386448103296446 690 17122418 SGTC_1694 st024011 44.9 µM -0.28979657771097 0.370685664472337 no 2139 0.385985933085343 710 2787533 SGTC_2568 diosmetin 100 µM -0.291164152678554 0.370146044385077 no 2140 0.385462888699696 689 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2984 9022109 38.96 µM -0.291623164064979 0.369964984097677 no 2141 0.38528738127579 683 6459207 SGTC_2818 7996756 12.99 µM -0.29204534021639 0.369798479170093 no 2142 0.385125978897358 656 2241621 SGTC_454 lyso-paf C-16 6.67 µM -0.292161568615452 0.369752643343678 no 2143 0.385081547051343 706 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3318 9139014 38.6185 µM -0.294032259612299 0.369015172717373 no 2144 0.384366626376973 685 16643984 SGTC_1836 st055642 81 µM -0.294184974113593 0.368954990290721 no 2145 0.384308280908168 699 8571 SGTC_414 piperonyl butoxide 100 µM -0.294975921353315 0.368643341638279 no 2146 0.384006136858983 686 5794 A potent inhibitor of cytochrome P450. SGTC_1981 st071826 47 µM -0.295374796022749 0.368486209981079 no 2147 0.38385379234882 657 11838600 SGTC_1282 0886-0010 32.4 µM -0.295953429864388 0.368258303553826 no 2148 0.383632823287015 670 2836211 YNL267W PIK1 SGTC_870 0573-2213 57.6 µM -0.296924030623934 0.367876117290298 no 2149 0.383262254647242 666 3916321 SGTC_2897 9048598 12.99 µM -0.299577591558708 0.366831912728935 no 2150 0.382249689446934 661 6467404 SGTC_3112 9123419 49.47 µM -0.30083814884695 0.366336214451756 no 2151 0.381768958275698 698 17015854 SGTC_3266 9136860 49.47 µM -0.301318355555377 0.366147437806061 no 2152 0.381585872629597 682 4871271 YPR165W RHO1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.301462587239792 0.366090744435473 no 2153 0.381530887417172 676 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3013 9080133 71.4286 µM -0.301811411388991 0.365953643675964 no 2154 0.381397915634249 674 17050193 SGTC_1970 st070122 35.8 µM -0.302105461405354 0.365838084465475 no 2155 0.381285834626714 722 102928 SGTC_1163 k060-0048 49.9 µM -0.302261693630722 0.365776691451291 no 2156 0.381226288721391 663 6809982 SGTC_1469 k284-2957 126 µM -0.302591479071774 0.365647110254491 no 2157 0.381100604471697 676 23884841 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.303055100293476 0.365464967458266 no 2158 0.380923935392683 675 688803 SGTC_1424 4048-1941 275 µM -0.305950147061989 0.364328278507703 no 2159 0.379821301801805 702 X1424 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.30620169385983 0.364229569256355 no 2160 0.379725541398103 697 5024745 SGTC_76 0433-0009 400.328 µM -0.306554947338393 0.364090964582467 no 2161 0.379591075113806 747 2841569 SGTC_61 0978-8327 98.565 µM -0.306887919444177 0.363960333904792 no 2162 0.379464342284562 712 6150059 YHR072W ERG7 SGTC_3274 9138298 49.47 µM -0.307329972530489 0.363786933309749 no 2163 0.379296112049716 684 17015756 SGTC_2506 ethyl hematommate 54.16 µM -0.307902269044108 0.36356248461264 no 2164 0.379078349585928 681 3940691 An allergen. SGTC_2060 5238662 140 µM -0.309382713277972 0.362982087284227 no 2165 0.378515209301454 700 790130 SGTC_2600 tangeritin 87.95 µM -0.310442615512056 0.362566753501435 no 2166 0.378112195646125 702 68077 A bioactive flavone. SGTC_3131 9127911 49.47 µM -0.31237930015174 0.361808261256464 no 2167 0.377376139961104 712 45595681 SGTC_1133 3473-0247 50 µM -0.312506324831597 0.36175853164342 no 2168 0.377327878535115 696 711311 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.312820302315006 0.361635620834168 no 2169 0.377208594969394 689 616764 SGTC_2961 9083290 32.55 µM -0.313037122779068 0.361550751809511 no 2170 0.377126229282253 699 17741490 SGTC_800 3448-7362 155 µM -0.313096619322023 0.361527464545475 no 2171 0.377103628732235 694 15991913 SGTC_1942 st076330 65.2 µM -0.315021518016001 0.360774326123979 no 2172 0.376372658017399 726 24208414 SGTC_2044 5102272 200 µM -0.315581001202826 0.360555523073967 no 2173 0.376160280063275 671 592666 SGTC_3221 9128209 49.47 µM -0.316791838672538 0.360082144348363 no 2174 0.375700778654053 687 16460723 SGTC_3041 9091929 49.47 µM -0.317407393673886 0.359841574381802 no 2175 0.375467248858892 678 25236887 SGTC_2934 9036370 36.88 µM -0.318948072404595 0.359239692964681 no 2176 0.374882944987318 687 6462800 SGTC_3113 9123498 49.47 µM -0.319491643246799 0.359027424873159 no 2177 0.374676863669119 699 8897275 SGTC_2864 9034755 47.6 µM -0.320574644108421 0.358604635491168 no 2178 0.374266377654575 672 4930451 SGTC_2455 5377712 9.75 µM -0.321383347824091 0.358289041067827 no 2179 0.373959950426271 657 2243908 SGTC_356 1634-0012 32.5 µM -0.321463418058875 0.358257799138972 no 2180 0.37392961521411 726 735457 SGTC_1862 st057513 3.81 µM -0.321686022921547 0.358170947813956 no 2181 0.373845283786861 677 5393163 SGTC_2727 riluzole 51.77 µM -0.321946912899619 0.358069168541102 no 2182 0.373746456146809 692 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1267 0828-0272 9.49 µM -0.322516419500811 0.357847025766111 no 2183 0.373530750397904 689 745334 SGTC_674 0498-0004 451 µM -0.323575085457587 0.3574342085572 no 2184 0.373129876459818 691 4231473 SGTC_71 0417-1750 47.813 µM -0.323733729966374 0.357372360923172 no 2185 0.373069816026136 642 6811472 SGTC_335 4077-0256 27.6 µM -0.324117790856423 0.357222650125473 no 2186 0.372924429103562 713 3121989 SGTC_2276 7947513 42.08 µM -0.324245507195246 0.357172869880205 no 2187 0.372876085868448 706 2105100 SGTC_2871 9038510 12.99 µM -0.324931420642176 0.35690556167107 no 2188 0.37261648792497 752 4945164 SGTC_3185 9108267 49.47 µM -0.325410091589495 0.356719059806097 no 2189 0.372435359401861 705 4910486 SGTC_525 k781-2675 26.7 µM -0.326543837719909 0.356277461377751 no 2190 0.372006463808786 661 3651118 YDL195W SEC31 SGTC_1756 st041558 35.5 µM -0.326763416698513 0.356191956783756 no 2191 0.371923415526901 727 3955792 SGTC_1375 2910-0797 186 µM -0.328207100382675 0.355629963035864 no 2192 0.371377539806156 704 742508 SGTC_673 1082-0474 110 µM -0.32847007112279 0.355527628150333 no 2193 0.371278134934563 720 3098046 SGTC_857 0438-0306 1.35 µM -0.328886622618686 0.355365548732855 no 2194 0.371120692983435 670 4686136 SGTC_1737 st035557 69.7 µM -0.331368154180686 0.354400532335421 no 2195 0.370183208313392 675 5716916 SGTC_2210 7115885 190.385 µM -0.338643930826914 0.351576536572256 no 2196 0.367438991975121 707 2927039 SGTC_2240 6690706 185.951 µM -0.339477186985994 0.351253637935379 no 2197 0.367125139980937 662 805876 SGTC_3005 9076496 71.4286 µM -0.339780990359964 0.351135936488822 no 2198 0.367010732301979 705 21368410 SGTC_2415 st077333 57.7 µM -0.340052223544541 0.35103086565752 no 2199 0.366908600033315 666 2766255 SGTC_2397 5161689 200 µM -0.340496069548329 0.350858952310261 no 2200 0.366741491103171 715 2259942 SGTC_2423 st077119 87.2 µM -0.341077748747899 0.350633698729118 no 2201 0.366522525930585 674 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1798 st045719 60.953 µM -0.341708587767865 0.350389467497867 no 2202 0.366285104318276 689 3980186 SGTC_2302 7771753 200 µM -0.344472014309739 0.349320328569358 no 2203 0.36524566950245 676 2203047 SGTC_2054 5233173 129 µM -0.344724566698013 0.349222678311797 no 2204 0.365150723704674 671 6889 SGTC_2304 7443016 91.4 µM -0.344927047617854 0.349144395569802 no 2205 0.365074607992901 712 939854 SGTC_2470 5664817 21.68 µM -0.3451272990853 0.349066981086814 no 2206 0.36499933559513 697 2859561 SGTC_2460 5552655 174.22 µM -0.3451790042354 0.349046993601897 no 2207 0.364979901023765 702 5401989 SGTC_2699 st077704 54.6 µM -0.345218757412657 0.349031626635438 no 2208 0.364964959112484 694 645852 SGTC_3022 9087993 49.47 µM -0.347260429879727 0.348242732219125 no 2209 0.364197837784799 683 17173644 SGTC_1101 ebselen 5.29 µM -0.347377529578111 0.348197505208859 no 2210 0.364153856160182 717 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_872 0588-0139 234 µM -0.349056997282516 0.347549088011579 no 2211 0.363523259839906 669 2047100 SGTC_1006 4099-6547 255 µM -0.349329462357726 0.347443935326425 no 2212 0.363420991110612 697 3146833 SGTC_787 4152-0075 138 µM -0.350324404225053 0.347060056293529 no 2213 0.363047626182981 674 9566539 SGTC_2459 5811157 9.22 µM -0.350922436312768 0.346829392671771 no 2214 0.362823269420795 693 2870684 YBR192W RIM2 SGTC_1738 st035555 74 µM -0.35193539711505 0.346438818734482 no 2215 0.362443356110313 736 5331140 SGTC_3080 9117754 49.47 µM -0.35225238863318 0.346316627746838 no 2216 0.362324495504682 729 9550191 SGTC_3002 9075603 71.4286 µM -0.353385702355633 0.345879899238424 no 2217 0.361899651565919 681 20105405 SGTC_2375 9072683 200 µM -0.353700090777545 0.345758784268716 no 2218 0.361781827280594 739 16798029 SGTC_393 acivicin 6.25 µM -0.353714061105203 0.345753402707011 no 2219 0.361776591883231 708 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_676 falcarinol 140 µM -0.353734116702341 0.345745677070578 no 2220 0.361769076068923 738 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2610 ononetin 44.17 µM -0.353870428531289 0.34569316995802 no 2221 0.361717994764734 710 259632 SGTC_889 0919-1524 82.7 µM -0.354902301639769 0.345295790321764 no 2222 0.361331392060484 702 3905452 SGTC_1581 himbacine 57.9 µM -0.355863153957767 0.344925914427832 no 2223 0.360971525350302 732 5281825 An alkaloid muscarinic receptor antagonist. SGTC_707 0865-0008 204 µM -0.357426151341596 0.344324562027362 no 2224 0.360386401034426 702 723043 SGTC_1310 1188-0297 994 nM -0.35892973176903 0.343746441039195 no 2225 0.359823828452526 700 1588352 SGTC_1911 st060208 74.3 µM -0.360162889978257 0.34327256888003 no 2226 0.359362662277648 704 688783 SGTC_7 0192-1582 4.227 µM -0.361519376384166 0.342751589241952 no 2227 0.358855611399966 703 252616 SGTC_980 1473-0395 201 µM -0.36279694462741 0.342261192644835 no 2228 0.358378287220717 703 768876 SGTC_3181 9108277 49.47 µM -0.362861080062066 0.34223658115848 no 2229 0.358354330808189 728 17097298 SGTC_1514 1189-1591 158 µM -0.362868625386112 0.342233685741687 no 2230 0.358351512451288 749 767698 YMR146C TIF34 SGTC_1771 st048882 4.1505 µM -0.363324048244877 0.342058940514272 no 2231 0.358181415541591 702 4580403 SGTC_625 k213-0058 121 µM -0.364913612965202 0.34144929160844 no 2232 0.357587946167207 685 3655420 SGTC_834 0312-0008 75.7 µM -0.365861963587454 0.341085765630878 no 2233 0.357234040073834 718 6385573 YIL048W NEO1 SGTC_3286 9117135 37.221 µM -0.367501047074376 0.34045781269155 no 2234 0.356622655473315 700 3438150 SGTC_555 4296-0685 37 µM -0.368369178405202 0.340125399907592 no 2235 0.356298988113212 713 2908540 YHR072W ERG7 SGTC_1242 0402-0103 60.1 µM -0.3690547964023 0.339862960372816 no 2236 0.356043440741042 693 432868 SGTC_2464 5717415 7.67 µM -0.369821878083936 0.339569430298049 no 2237 0.355757606406318 705 5285744 SGTC_1018 4259-0013 28.1 µM -0.371502848045971 0.338926533787865 no 2238 0.355131517530181 720 6801262 SGTC_3263 9137018 49.47 µM -0.371524860029874 0.338918118285614 no 2239 0.355123321604006 704 43844957 SGTC_2943 9068529 45.32 µM -0.372781060483082 0.338437987862487 no 2240 0.354655700001119 698 3270634 SGTC_757 1066-0008 322 µM -0.374341952046177 0.337841767731911 no 2241 0.354074961987612 712 6842497 SGTC_518 1021-0119 62.6 µM -0.374566081486252 0.337756189446324 no 2242 0.353991601260368 734 1097762 SGTC_1317 1273-0028 910 nM -0.37513073739831 0.337540626736801 no 2243 0.353781619151596 713 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_781 4335-2806 94.4 µM -0.375322982762923 0.337467247417699 no 2244 0.353710137816782 745 845254 SGTC_3256 9138902 49.47 µM -0.375342001693359 0.337459988300733 no 2245 0.353703066412761 725 17228773 SGTC_573 3702-0553 84.7 µM -0.376140589831664 0.337155238996401 no 2246 0.353406189972937 703 1222756 SGTC_2643 anethole 100 µM -0.377127012161061 0.336778957752892 no 2247 0.353039608971332 736 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_3264 9137442 49.47 µM -0.379291310527942 0.335953935941748 no 2248 0.352235775821446 721 17015726 SGTC_83 0170-0301 39.027 µM -0.379322084704813 0.335942210635348 no 2249 0.352224350859496 690 3089716 SGTC_974 1326-0144 138 µM -0.380036154395922 0.335670186932575 no 2250 0.351959288823716 725 5411856 SGTC_2952 9073731 13.78 µM -0.380087256288845 0.335650723047875 no 2251 0.351940322602678 722 16457353 SGTC_1944 st076371 56.9 µM -0.382814300681863 0.33461267670824 no 2252 0.350928728671453 709 24208455 SGTC_107 0358-0022 2.6945 µM -0.383220245169342 0.334458262199247 no 2253 0.350778234137367 747 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2424 5537928 59.2 µM -0.386009639012001 0.333397981770102 no 2254 0.349744765064278 722 5382802 SGTC_252 miconazole 1.30953 nM -0.386930780675367 0.333048136949217 no 2255 0.34940372646531 721 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2652 actinonin 100 µM -0.387090372916697 0.332987539398859 no 2256 0.349344652226182 716 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_695 3505-6186 243 µM -0.387747156874957 0.332738202900443 no 2257 0.349101577251005 736 1819379 SGTC_3052 9092717 49.47 µM -0.387751934189205 0.332736389547778 no 2258 0.349099809399222 735 25237534 SGTC_691 1548-0686 185 µM -0.387983323335461 0.332648564523025 no 2259 0.349014187444971 710 46495133 SGTC_1354 1498-1681 81 µM -0.388432153205192 0.33247823486176 no 2260 0.348848126851562 725 5754243 SGTC_1776 st049249 45.9 µM -0.389863576437059 0.331935244988049 no 2261 0.348318714373693 700 1822314 SGTC_1920 st075728 45.7 µM -0.389893422376368 0.331923927109782 no 2262 0.348307678980851 732 3400306 SGTC_605 1315-0399 119 µM -0.390346462983681 0.331752148424508 no 2263 0.34814018516387 712 24020461 SGTC_2980 9014342 25.29 µM -0.390735925959501 0.33160450463867 no 2264 0.347996220330898 739 2996599 SGTC_2442 5158906 48.48 µM -0.391301601876194 0.331390105856777 no 2265 0.347787157476081 689 1893835 SGTC_919 tnp00227 403.569 nM -0.392094957208584 0.331089506597808 no 2266 0.347494026689206 731 1269246 A methoxyflavone. YNL221C POP1 SGTC_580 1123-0028 41 µM -0.394907205968392 0.330024834213781 no 2267 0.346455685871739 724 1677248 YPR107C YTH1 SGTC_541 4513-1321 94 µM -0.3952301465714 0.329902661936126 no 2268 0.346336523116669 700 747515 SGTC_1962 st076595 64.5 µM -0.3982854908122 0.32874768812755 no 2269 0.345209877177914 715 279619 SGTC_2446 5162541 200 µM -0.398956237339089 0.328494352470219 no 2270 0.344962725194285 699 1549321 SGTC_1848 st056003 16.4 µM -0.399556941431043 0.32826753818545 no 2271 0.344741438084895 694 146492 SGTC_3284 9108171 64.8615 µM -0.399812984146393 0.328170880624868 no 2272 0.34464713332003 737 8687505 SGTC_20 0481-0013 4.944 µM -0.39992152295959 0.328129910085869 no 2273 0.344607159593942 726 182045 SGTC_89 0302-0250 142.109 µM -0.400072622106328 0.328072877586383 no 2274 0.344551514224858 719 4203518 YLR208W SEC13 SGTC_3242 9133940 49.47 µM -0.40078688165314 0.327803333996972 no 2275 0.344288519003288 743 17248444 SGTC_1540 guanosine 70.6 µM -0.401042452314355 0.327706909836968 no 2276 0.34419443442833 719 6802 Guanosine is a purine nucleoside SGTC_2887 9044784 58.44 µM -0.401916126515555 0.32737736841533 no 2277 0.343872876995206 717 6465546 SGTC_250 brefeldin a 552.239 µM -0.402418940136802 0.327187772951667 no 2278 0.343687866664963 710 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1905 st060207 84.5 µM -0.402539441332419 0.327142342298705 no 2279 0.34364353379481 692 1948547 SGTC_2686 alizarin 95.37 µM -0.402713740269759 0.327076633668598 no 2280 0.343579412325935 695 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2452 5863136 48.41 µM -0.403575840910175 0.326751710813628 no 2281 0.343262327097917 734 2184096 SGTC_2656 pseudo-anisatin 100 µM -0.403917939411468 0.326622811416915 no 2282 0.343136531997246 730 6708809 A neurotoxin. SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.403922335289929 0.326621155227191 no 2283 0.343134915675377 747 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_906 1165-0455 526 µM -0.406032679341252 0.325826457781791 no 2284 0.342359294525828 748 3252859 SGTC_2781 5567276 71.43 µM -0.407633698985882 0.325224085115774 no 2285 0.341771309936509 746 2853274 SGTC_823 0417-1665 178 µM -0.410450928536568 0.324165230685259 no 2286 0.340737596747626 752 3429856 SGTC_582 0987-0078 156 µM -0.410792681640756 0.324036879393856 no 2287 0.340612279953015 742 1625765 SGTC_832 4083-0019 164 µM -0.411064947632201 0.323934640157291 no 2288 0.340512455845037 728 1990758 SGTC_2975 9084847 53.72 µM -0.41243367572318 0.323420867216349 no 2289 0.340010792212206 706 27211724 SGTC_2581 avocatin a 64 µM -0.415151424848017 0.322401716804273 no 2290 0.339015527878926 765 6710728 A skin care supplement. SGTC_2925 9010536 32.5 µM -0.415766052576895 0.322171417244456 no 2291 0.338790601029065 726 2994177 SGTC_2516 gossypol 71.55 µM -0.420034281141673 0.320574008883739 no 2292 0.337230205316967 746 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_100 0086-0128 49.5915 µM -0.420183041403325 0.320518394189021 no 2293 0.337175871226319 772 93297 SGTC_2774 tamoxifen 10.92 µM -0.420344112261418 0.320458181665932 no 2294 0.337117044568912 726 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_852 0418-0143 439 µM -0.420595825581593 0.320364094069604 no 2295 0.337025121245459 736 5369229 SGTC_2714 st079313 56.9 µM -0.42068649231778 0.320330206695625 no 2296 0.336992012994711 718 2939799 SGTC_3059 1327-0034 3 µM -0.421379124705326 0.32007137959241 no 2297 0.336739130096017 712 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_445 e6 berbamine 66 µM -0.421690409744389 0.31995508520212 no 2298 0.33662550269308 742 6610268 A calcium/calmodulin antagonist. SGTC_1463 k081-0032 34.1 µM -0.422924923345599 0.319494051958624 no 2299 0.336175019009323 730 977755 SGTC_2735 sertaconazole 140 nM -0.423593257535134 0.319244576617744 no 2300 0.33593123669934 725 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2680 butyl paraben 22.24 µM -0.425085528687635 0.318687838076173 no 2301 0.335387163425526 741 7184 An antifungal and steroid mimetic. SGTC_193 1273-0060 1.558 µM -0.425425988536466 0.318560876112926 no 2302 0.335263082071281 744 2847393 YHR072W ERG7 SGTC_3234 9132280 49.47 µM -0.425566133957337 0.318508620226777 no 2303 0.335212010979372 723 17612295 SGTC_2580 diallyl disulphide 81.36 µM -0.426192558498606 0.318275090062999 no 2304 0.334983769733197 689 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2723 salbutamol 83.58 µM -0.426312861405768 0.318230249575313 no 2305 0.334939943675348 750 9884233 β2-adrenoceptor agonist SGTC_622 1348-1566 26.3 µM -0.426955526545135 0.317990754210816 no 2306 0.334705860408105 725 7340407 SGTC_3116 9124943 49.47 µM -0.427292251259546 0.317865300871861 no 2307 0.334583238000105 704 41905195 YPL160W CDC60 SGTC_1888 azatryptophan 97.5 µM -0.427871259102939 0.317649629121269 no 2308 0.334372426493492 737 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1845 st056753 3.01 µM -0.428221873254105 0.317519060669336 no 2309 0.334244796440833 703 5375839 SGTC_2328 6201408 200 µM -0.428424408222046 0.317443647138187 no 2310 0.334171078687123 761 2890418 SGTC_1707 st032323 6.317 µM -0.428632909392512 0.317366020016956 no 2311 0.334095196063943 734 3132057 YMR211W DML1 SGTC_2425 5628681 7.85 µM -0.428672153957 0.317351409761792 no 2312 0.334080914022276 742 5714958 SGTC_1087 pterostilbene 9.05 µM -0.429011042424457 0.31722525771155 no 2313 0.333957594349025 737 5281727 Similar to reservatol, lowers cholesterol. SGTC_1191 1487-1166 10.6 µM -0.430340839891545 0.316730442643147 no 2314 0.333473861577763 762 3955771 SGTC_2721 ifenprodil 61.44 µM -0.430765918376378 0.316572340840061 no 2315 0.333319291561004 709 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1081 sertraline 6 µM -0.431072089522741 0.316458485661466 no 2316 0.333207976995467 738 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1774 st048371 48.465 µM -0.432786507603148 0.315821270461791 no 2317 0.332584938132005 728 4242727 SGTC_1297 1068-0111 14.1 µM -0.433736699328695 0.315468338496382 no 2318 0.332239826682014 727 767057 SGTC_2243 6634756 200 µM -0.434599864915061 0.31514787670262 no 2319 0.331926446548211 699 885676 SGTC_1429 4049-0205 9.46 µM -0.435184717612159 0.314930821316187 no 2320 0.331714177234017 726 22774478 SGTC_1394 3474-0001 65.7 µM -0.435540190049086 0.314798926654343 no 2321 0.331585186710261 709 5017666 YIL048W NEO1 SGTC_1824 st053723 68.6 µM -0.435735247103241 0.314726562628053 no 2322 0.331514414709305 753 675225 SGTC_2326 6164455 177.58 µM -0.435869046100932 0.314676928782065 no 2323 0.331465872274139 732 2888790 SGTC_2314 7727897 200 µM -0.436177729039613 0.314562433064389 no 2324 0.331353892537952 709 900724 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.436582035420625 0.314412495968769 no 2325 0.331207246655176 747 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2294 7971431 200 µM -0.436834470341863 0.314318895952312 no 2326 0.331115699161571 778 5741572 SGTC_469 w7 172 µM -0.438054965158725 0.313866518736835 no 2327 0.330673219668889 719 45115570 A P450 inhibitor. SGTC_1240 0356-0016 42.1 µM -0.438090580013354 0.31385332226322 no 2328 0.330660311370308 718 4305613 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.438397402998329 0.313739644131001 no 2329 0.330549114353889 735 2346 DNA damaging agent; causes G2/M arrest. SGTC_2071 5230951 39.92 µM -0.438682828181488 0.313633909773528 no 2330 0.330445685633161 724 1799272 SGTC_3302 9125395 16.351 µM -0.44001024872157 0.313142374609959 no 2331 0.329964842249381 725 17599668 SGTC_2440 5628896 157.78 µM -0.440109027631785 0.31310581067975 no 2332 0.329929071899076 750 5522048 SGTC_2696 st077691 74.316 µM -0.441039299068307 0.312761552265812 no 2333 0.329592273323921 767 757133 SGTC_2438 5259590 200 µM -0.441314329559564 0.312659805095367 no 2334 0.329492726816888 742 1201127 SGTC_2224 6650123 117.647 µM -0.441482078969708 0.312597753428563 no 2335 0.329432016324594 729 2908370 SGTC_2790 5423970 71.43 µM -0.441552996391927 0.312571522181086 no 2336 0.329406351824149 734 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2826 7992541 19.48 µM -0.442516247482451 0.312215324715475 no 2337 0.329057837877726 784 2985066 SGTC_3035 9091303 49.47 µM -0.442789660994947 0.312114251982662 no 2338 0.328958941165732 741 25237002 SGTC_1093 fluphenazine 7.97 µM -0.443495557942479 0.311853368562065 no 2339 0.328703665749971 757 6602611 An atypical antipsychotic. SGTC_2858 9025781 8.96 µM -0.444243106633892 0.31157719449273 no 2340 0.32843341481986 737 4894980 YPL153C RAD53 SGTC_3046 9092212 49.47 µM -0.44812002740118 0.310146609135032 no 2341 0.327033287476953 720 25236637 SGTC_2063 5246145 200 µM -0.449076605756284 0.309794071719812 no 2342 0.326688197938326 769 711240 SGTC_1171 0368-0077 21.4 µM -0.449083542672702 0.309791515826691 no 2343 0.326685695958458 724 3239779 SGTC_1885 st057546 99.9 µM -0.449154121238241 0.309765511816665 no 2344 0.326660240400712 725 702008 SGTC_637 1181-0519 7.26 µM -0.450040880912395 0.309438874690468 no 2345 0.326340481752324 743 6252091 YGR060W ERG25 SGTC_1180 1193-0155 285 µM -0.450977482924285 0.309094041599541 no 2346 0.326002888889697 759 2921347 SGTC_2982 9019404 25.97 µM -0.45176528962362 0.308804121339621 no 2347 0.325719038831006 712 22333232 SGTC_977 1348-1378 135 µM -0.451842694301925 0.308775642114814 no 2348 0.325691155048016 746 X977 SGTC_3128 9127691 49.47 µM -0.4521746365664 0.308653524832321 no 2349 0.325571589277848 757 41316314 SGTC_2575 plumbagin 510 nM -0.452468608853657 0.308545393880749 no 2350 0.325465715295552 752 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1224 0823-0416 294 µM -0.453383972715469 0.308208804679579 no 2351 0.325136137648932 752 3598164 SGTC_1127 asiatic acid 681.4 nM -0.454119212556795 0.307938565756269 no 2352 0.324871512853684 732 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1028 k015-0029 4.8 µM -0.455273937549255 0.307514354411896 no 2353 0.324456086883544 752 4588309 SGTC_972 1319-0219 195 µM -0.45724801162181 0.306789734904872 no 2354 0.323746396324189 756 23903702 SGTC_1025 k007-0731 70 µM -0.457573872329029 0.306670194316035 no 2355 0.323629309108544 726 6256118 SGTC_2449 5812982 45.77 µM -0.458479624664836 0.306338031031658 no 2356 0.323303948836656 751 776185 SGTC_1046 2001-0062 216 µM -0.458715071211328 0.306251712611136 no 2357 0.323219394902051 746 739778 SGTC_134 0269-0018 6.916 µM -0.458763945159369 0.306233795997903 no 2358 0.323201844357234 703 4378915 SGTC_2189 6047310 154.431 µM -0.46078166435623 0.30549452878326 no 2359 0.322477628959349 741 711535 SGTC_2817 7995342 71.43 µM -0.460898321724255 0.305451811176878 no 2360 0.322435777951596 775 18879975 SGTC_998 3996-0085 177 µM -0.461383197920641 0.305274287552333 no 2361 0.32226185199844 737 715391 SGTC_3101 9120531 49.47 µM -0.463002851134294 0.304681629741469 no 2362 0.321681161723825 791 24824904 SGTC_690 glyoxal 20.3 µM -0.463676482420321 0.304435287688141 no 2363 0.321439774462715 752 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_735 3076-0345 636 µM -0.464968538544348 0.303963040447588 no 2364 0.32097699350974 726 2888990 SGTC_253 dyclonine 31.25 µM -0.466080481944051 0.303556886216364 no 2365 0.320578946757793 735 3180 An oral anasthetic. SGTC_1213 1315-0166 115 µM -0.466208312234428 0.303510209794906 no 2366 0.320533200056119 718 768401 SGTC_2369 9071472 200 µM -0.466259902759681 0.303491372749108 no 2367 0.320514738096437 731 17296037 SGTC_1335 1486-0900 202 µM -0.466307210899476 0.303474099772877 no 2368 0.320497809002806 718 X1335 SGTC_2047 4141938 200 µM -0.468047319130936 0.302839063178175 no 2369 0.319875375585819 748 3807862 SGTC_422 cantharidin 155 µM -0.468124111524951 0.302811052208608 no 2370 0.319847918755981 742 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1268 0828-0275 2.46 µM -0.468420669207595 0.302702890042091 no 2371 0.319741894945843 748 745337 SGTC_3 0833-0587 95.581 µM -0.468830953193601 0.302553277529373 no 2372 0.319595236563212 737 5382644 SGTC_2104 5389443 200 µM -0.468843065909517 0.302548861058719 no 2373 0.319590907231466 760 2244536 SGTC_810 3825-7150 143 µM -0.468946929697694 0.302510992012161 no 2374 0.319553785204263 716 22330411 YGL099W LSG1 SGTC_3247 9135149 49.47 µM -0.47193366186715 0.301422931038839 no 2375 0.318487070013724 757 8934436 YOR116C RPO31 SGTC_3163 9099914 49.47 µM -0.47239447848173 0.301255213375815 no 2376 0.318322622382218 748 16268368 SGTC_1182 1222-0449 220 µM -0.472825074377577 0.301098532767655 no 2377 0.318168991706258 743 658318 SGTC_3206 9114350 49.47 µM -0.473891257910068 0.300710739488122 no 2378 0.317788726769213 751 17087243 SGTC_1173 0443-0020 122 µM -0.474813062267659 0.300375641734069 no 2379 0.317460110912105 750 5331295 SGTC_2194 5927483 104.545 µM -0.475926891633047 0.299970963603007 no 2380 0.317063231552212 715 760979 SGTC_2354 9060492 162 µM -0.476169781986997 0.299882749097069 no 2381 0.316976712851947 760 6471895 SGTC_288 1315-0019 35.1 µM -0.477460915429529 0.299414024066504 no 2382 0.316516973030487 750 6811474 SGTC_585 0kpi-0023 191 µM -0.479728846782366 0.298591493740565 no 2383 0.315710106578039 752 64601 SGTC_1985 st071382 65.5 µM -0.479876938759057 0.298537819700178 no 2384 0.315657450082501 771 6123237 SGTC_2157 5649910 96.377 µM -0.480094704338187 0.298458901327817 no 2385 0.315580026808743 761 2858091 SGTC_2769 toremifene 3.73 µM -0.481960788928826 0.297783020748461 no 2386 0.314916900673224 734 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_953 1188-0045 9.7 µM -0.482911004502374 0.297439128910722 no 2387 0.314579463911837 752 6144426 SGTC_1378 2093-0007 380 nM -0.482930904700307 0.297431928783709 no 2388 0.314572398687135 786 3618014 SGTC_1775 st081588 35.1725 µM -0.48397268677532 0.297055110920139 no 2389 0.314202626660276 782 1426443 YGL099W LSG1 SGTC_3203 9113543 49.47 µM -0.48444872698178 0.29688299746709 no 2390 0.314033722108454 736 17018012 SGTC_1772 st048439 82.2 µM -0.48478256493447 0.296762324801553 no 2391 0.313915295787304 729 2927068 YDL195W SEC31 SGTC_3072 9116419 49.47 µM -0.48506924490156 0.296658716294657 no 2392 0.313813613675695 752 17170162 SGTC_689 0833-0039 98 µM -0.485281120820213 0.296582153236373 no 2393 0.313738472792033 787 5374726 SGTC_2567 aureobasidin a 60 nM -0.485610522504156 0.296463139282296 no 2394 0.313621667243908 738 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_982 1491-0518 27.5 µM -0.487646452302081 0.295728037086266 no 2395 0.312900143281715 744 3091256 SGTC_151 3013-0144 2.285 µM -0.487714122688976 0.295703618092797 no 2396 0.31287617349614 755 906558 YHR107C CDC12 SGTC_340 k038-0059 454 µM -0.487860623300684 0.295650756230866 no 2397 0.312824283666544 733 23733424 SGTC_1572 epiandrosterone 68.9 µM -0.48831977370074 0.295485108992893 no 2398 0.31266167877751 757 441302 A steroid. SGTC_2293 7624732 200 µM -0.489113540295809 0.29519884332283 no 2399 0.312380657912703 758 894453 SGTC_1695 st026914 34.495 µM -0.490287970473423 0.294775528696558 no 2400 0.311965069091071 758 3289191 SGTC_2624 nerol 100 µM -0.490717088177045 0.294620926255573 no 2401 0.311813279340401 788 637566 A natural product oil. SGTC_2100 5377183 190 µM -0.491249069253203 0.294429316166793 no 2402 0.311625148593446 733 2844202 SGTC_1607 st000305 50.6 µM -0.492012198065158 0.294154551284869 no 2403 0.311355360193332 778 5457690 SGTC_698 k064-0052 127 µM -0.49203466656727 0.294146463286168 no 2404 0.311347418453608 772 5088751 SGTC_2622 2-methoxyxanthone 59.94 µM -0.493668066662379 0.293558762868069 no 2405 0.310770310573092 757 71034 A hepatoprotective. SGTC_647 0140-0236 81 µM -0.495565920940229 0.292876595049328 no 2406 0.310100350868825 750 990837 SGTC_1298 1079-1278 263 µM -0.496545046668143 0.292524944474594 no 2407 0.30975495680669 779 2840950 SGTC_2821 7996764 71.43 µM -0.496699051525015 0.292469651876127 no 2408 0.309700645693094 707 2987135 SGTC_1288 0973-0013 65.5 µM -0.497188148708985 0.292294082790222 no 2409 0.309528188991727 751 4315430 SGTC_2471 5466956 24.79 µM -0.49886228331631 0.291693497356797 no 2410 0.308938203185426 762 724419 SGTC_2528 xanthyletin 44.79 µM -0.499893660735558 0.291323783640465 no 2411 0.30857497808911 771 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1992 st073643 23.3 µM -0.500190386493233 0.291217458074298 no 2412 0.308470513433668 773 3161292 SGTC_1051 3253-3903 78 µM -0.500452469614691 0.291123561053922 no 2413 0.308378257886789 757 5509239 SGTC_1697 st025554 27.742 µM -0.501943670394605 0.290589574981658 no 2414 0.307853572609152 750 1269519 SGTC_2028 5153890 36.43 µM -0.502195964168062 0.290499276112934 no 2415 0.307764840786666 770 2830968 YPR165W RHO1 SGTC_1260 0700-1617 7.75 µM -0.502522344944629 0.290382480133477 no 2416 0.307650069213877 739 2853078 SGTC_92 0063-0024 660.874 µM -0.503779911314258 0.289932663314628 no 2417 0.307208022940134 764 3594437 SGTC_1161 k007-0610 110 µM -0.50750996392282 0.288600392568936 no 2418 0.305898523481496 778 5843850 SGTC_2138 5575593 77.673 µM -0.507859458593559 0.288475710734076 no 2419 0.305775954021053 780 762213 SGTC_1932 st074806 40.9 µM -0.507935279421858 0.288448665089395 no 2420 0.305749366163397 775 17251235 SGTC_2621 lithochol-11-enic acid 100 µM -0.509049709924144 0.288051280454528 no 2421 0.305358690420845 787 6708711 SGTC_2405 ticlatone 3.52 µM -0.51127252441854 0.287259439837858 no 2422 0.304580120662048 749 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_921 1561-0023 372 µM -0.512189952249855 0.286932922055181 no 2423 0.304259037253326 775 24050882 SGTC_3317 9138495 8.753 µM -0.512855901468856 0.286696017137693 no 2424 0.304026061357277 780 17020139 SGTC_185 k048-0037 25.491 µM -0.515354482725998 0.285807999049962 no 2425 0.303152666673883 771 6827589 SGTC_3350 9150499 3.57 µM -0.51576321713243 0.285662855781166 no 2426 0.303009897869421 776 4910996 YPR165W RHO1 SGTC_2163 5671233 125 µM -0.517033596211178 0.285211962981664 no 2427 0.302566353259662 744 701023 SGTC_1623 st003709 20.3 µM -0.517606716406191 0.285008657786418 no 2428 0.302366347364115 747 16192618 SGTC_88 0180-0332 8.668 µM -0.521256699921123 0.283715508834045 no 2429 0.301093980214541 747 3101745 SGTC_2162 5663267 200 µM -0.521310145463255 0.283696594559429 no 2430 0.301075367284649 790 6456493 SGTC_1049 3226-0134 66 µM -0.52477731148078 0.282470863396473 no 2431 0.299869002795301 763 5702385 SGTC_1401 3807-4679 7.6 µM -0.525522668556184 0.282207693728455 no 2432 0.299609949557114 775 3291456 SGTC_3088 9117578 49.47 µM -0.52568300957168 0.282151096167133 no 2433 0.299554235349527 791 678341 SGTC_91 0417-1751 58.384 µM -0.526036028507196 0.282026505947707 no 2434 0.299431587278473 781 6795624 SGTC_2853 9015042 58.44 µM -0.527332735469556 0.281569089468249 no 2435 0.298981272691409 751 6457456 SGTC_208 k072-0098 12.366 µM -0.529675536747669 0.280743569125337 no 2436 0.298168456001221 783 5948901 SGTC_1947 st076332 61.6 µM -0.529740099586679 0.280720836046658 no 2437 0.298146070683656 779 24208416 SGTC_170 4197-0004 226 µM -0.530177519397208 0.280566840577432 no 2438 0.297994428045202 777 218692 SGTC_361 000s-0510 1.45 µM -0.530996103463931 0.280278764521541 no 2439 0.29771073967028 766 660 SGTC_2618 avocadyne 43.43 µM -0.532301465677935 0.279819678134643 no 2440 0.297258608634193 782 3015189 SGTC_2178 5812956 200 µM -0.533013443900238 0.279569434405935 no 2441 0.297012137029258 768 5403383 SGTC_358 0075-0058 9.45 µM -0.533283261595283 0.279474628180303 no 2442 0.296918756355102 832 1069125 SGTC_370 0180-0345 38.7 µM -0.53344461621663 0.279417940239692 no 2443 0.296862919871697 747 3989527 SGTC_693 4161-2696 114 µM -0.533495393131118 0.279400102186708 no 2444 0.296845349603688 785 805759 SGTC_3349 9149703 23.001 µM -0.533683627487921 0.279333979828109 no 2445 0.296780219273109 776 4910494 SGTC_3355 9151058 44.0485 µM -0.535536137119675 0.27868364212283 no 2446 0.296139587997707 766 17015728 SGTC_1246 0422-0085 105 µM -0.536310362286975 0.27841206304008 no 2447 0.29587203509088 790 264295 SGTC_2673 kobusone 100 µM -0.537365691385606 0.278042087468246 no 2448 0.295507518583073 782 6710676 An epoxy ketone and protein crosslinker. SGTC_891 0929-0073 133 µM -0.537442745492173 0.278015083363165 no 2449 0.295480911760319 797 5603632 SGTC_447 ml7 120 µM -0.538132718497981 0.277773334954282 no 2450 0.295242712844545 780 4216 Selective myosin light chain kinase inhibitor. SGTC_2451 5856223 45.7 µM -0.538456491259832 0.277659928883729 no 2451 0.29513096747014 779 2179896 SGTC_336 4111-0029 111 µM -0.539050375929954 0.27745197103791 no 2452 0.29492604761181 786 3131175 SGTC_317 4495-0002 170 µM -0.540270484688215 0.277024970231307 no 2453 0.294505255038335 771 15991618 SGTC_2787 5284540 71.43 µM -0.540345144723213 0.276998851946461 no 2454 0.294479515194335 783 736958 SGTC_1762 st045503 25.4615 µM -0.540720289024174 0.27686763364117 no 2455 0.294350195911374 771 4645554 SGTC_607 4491-0986 66.8 µM -0.542752266675368 0.276157416166654 no 2456 0.293650191205228 779 698981 YDR232W HEM1 SGTC_338 4055-0136 114 µM -0.542904839750814 0.276104124891463 no 2457 0.293597661768526 774 2900563 SGTC_2521 angolensin 13.4 µM -0.543922609218584 0.27574876391451 no 2458 0.293247364926942 770 821428 A flavenoid. SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.544014495810727 0.275716692166603 no 2459 0.29321574885187 812 688798 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.5446460098385 0.275496320519931 no 2460 0.292998502081518 804 5393153 SGTC_1743 st037606 46.3785 µM -0.544992885074165 0.27537531262953 no 2461 0.292879205519349 731 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_765 1319-0117 244 µM -0.545300886071615 0.275267887995203 no 2462 0.292773297399745 754 3487746 YGL099W LSG1 SGTC_52 0329-0193 875 nM -0.546295328821452 0.274921186985229 no 2463 0.292431473332762 803 3739292 SGTC_1732 st034308 51.822 µM -0.546487890958377 0.27485407729048 no 2464 0.292365304571924 757 830119 SGTC_2855 9016525 58.44 µM -0.547109921772069 0.274637348952848 no 2465 0.292151608118807 770 43811474 SGTC_1473 k844-0725 134 µM -0.547293017700183 0.274573570623673 no 2466 0.292088720018945 777 54682906 SGTC_611 3453-1652 23.7 µM -0.547577947059183 0.274474334898267 no 2467 0.291990867645732 795 1560575 SGTC_733 4069-0007 56.1 µM -0.548287901195567 0.274227147772312 no 2468 0.291747116800197 780 5717425 YNL287W SEC21 SGTC_3032 9089427 49.47 µM -0.549685976512551 0.273740696819288 no 2469 0.291267388512401 770 17173707 SGTC_1385 3091-4834 14.1 µM -0.549927604460475 0.273656667268666 no 2470 0.291184514888029 767 4072814 SGTC_960 1222-0186 7.7 µM -0.550775302952822 0.273361969037756 no 2471 0.290893858112443 791 3126296 SGTC_1628 st004252 77.7 µM -0.550864985700365 0.273330800464809 no 2472 0.290863115845954 748 692968 SGTC_2332 7982454 138.89 µM -0.552755473084506 0.272674185498827 no 2473 0.290215431116971 790 2981748 SGTC_292 k038-0015 474 µM -0.552841425035662 0.272644350786792 no 2474 0.290185999872812 792 46368540 SGTC_553 k007-0256 45.7 µM -0.555225973303475 0.271817298716149 no 2475 0.289370052700916 773 6287000 SGTC_2083 5306046 65.942 µM -0.556464410884693 0.271388254538334 no 2476 0.288946708596986 791 539837 SGTC_2391 6285546 200 µM -0.557058771240715 0.27118246430263 no 2477 0.2887436376283 774 846083 SGTC_2323 6148992 148.28 µM -0.557467232218471 0.271041084646523 no 2478 0.288604120577814 779 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1264 0783-0040 158 µM -0.557691886536293 0.270963341240174 no 2479 0.288527399472439 771 2855798 SGTC_2570 licareol 100 µM -0.558133645873785 0.270810499377789 no 2480 0.28837656343798 781 443158 SGTC_818 4072-2707 53.5 µM -0.558268709620561 0.270763778012869 no 2481 0.288330454166145 772 882871 SGTC_880 0833-0487 87.2 µM -0.55921970891635 0.270434921498625 no 2482 0.288005891959671 775 76075 SGTC_2987 9018338 71.43 µM -0.559275795993496 0.270415532765807 no 2483 0.287986755643987 785 5055682 SGTC_2085 5307070 144.047 µM -0.560943922181906 0.269839196275402 no 2484 0.28741788327995 803 2840351 SGTC_792 4534-1957 155 µM -0.560967898089729 0.269830917100438 no 2485 0.287409710777286 756 1717904 SGTC_2895 9054447 58.44 µM -0.561003903786173 0.269818484130868 no 2486 0.287397437969858 778 2697450 SGTC_44 0929-0055 61.211 µM -0.562187691419038 0.269409875410686 no 2487 0.286994073339799 750 1379590 SGTC_2053 5265679 138 µM -0.562334651060681 0.269359170913415 no 2488 0.286944016925455 792 764595 SGTC_1568 digitonin 820 nM -0.563683513323736 0.268894005654472 no 2489 0.286484769761039 815 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1121 fusaric acid 630.51 nM -0.564208685397618 0.268713005286468 no 2490 0.286306058787813 755 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.564324775296305 0.268673003206662 no 2491 0.286266561663203 800 91467 include heat shock SGTC_546 peri-Naphthalide 147 µM -0.564491804519457 0.268615453782318 no 2492 0.286209738054066 768 223824 A penicillin ester. SGTC_2480 5767542 37.17 µM -0.564921848133626 0.268467312041431 no 2493 0.286063461184387 780 2867358 SGTC_3352 9151559 45.5865 µM -0.565069502052592 0.268416457585384 no 2494 0.286013245743849 761 17159339 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.565297392959584 0.268337977690181 no 2495 0.285935750827633 799 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1441 4106-0040 13 µM -0.567142482055957 0.267703000717645 no 2496 0.285308691155083 778 2904180 SGTC_1080 nisoldipine 24.4 µM -0.568000829602605 0.267407863550766 no 2497 0.285017202310155 795 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2720 fluspirilene 36.88 µM -0.56988180416871 0.266761677223595 no 2498 0.284378933476602 791 3396 An atypical antipsychotic. SGTC_158 k038-0087 26.446 µM -0.572660771315007 0.265808442695551 no 2499 0.283437201775663 761 X158 SGTC_1214 0358-0031 63.7 µM -0.57493985627971 0.265027967155873 no 2500 0.282665986746065 804 4301366 SGTC_3305 9127027 53.8275 µM -0.575119311830498 0.264966561857989 no 2501 0.282605303994195 790 41905295 SGTC_1488 4013-0813 75.9 µM -0.576296265232785 0.264564016474852 no 2502 0.282207473422434 777 2910057 SGTC_2909 7941780 10.49 µM -0.576410487307877 0.264524966443149 no 2503 0.282168878742562 784 1243215 SGTC_1249 0481-0015 10.2 µM -0.577349912070627 0.264203908931768 no 2504 0.281851551423538 818 4227577 SGTC_1413 3910-0535 34.4 µM -0.577855528984688 0.264031191644582 no 2505 0.281680830823204 779 2876951 SGTC_993 3909-8757 62.7 µM -0.578753123724498 0.263724717651562 no 2506 0.281377882520752 789 4288324 YLR208W SEC13 SGTC_2661 dactinomycin 12.96 µM -0.580999344730841 0.262958565800348 no 2507 0.280620447589636 793 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1362 1611-0397 101 µM -0.581776239238635 0.262693843959075 no 2508 0.280358705365954 797 27816 SGTC_1513 0337-0559 19 µM -0.582036392295398 0.262605228948317 no 2509 0.280271084065659 784 775073 SGTC_324 1315-0088 19.6 µM -0.583459489836256 0.262120755151997 no 2510 0.279792010114844 800 6787421 SGTC_2729 fluphenazine 10.66 µM -0.583602102648523 0.262072229863633 no 2511 0.279744022607052 804 3372 An atypical antipsychotic. SGTC_1438 4092-1045 4 µM -0.584656150461394 0.261713723472463 no 2512 0.279389471993811 799 1351342 SGTC_495 decylubiquinone 155 µM -0.585956291490028 0.261271861878603 no 2513 0.278952443780018 811 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3063 1327-0034 4 µM -0.587293562525157 0.260817781583724 no 2514 0.278503281929855 795 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1147 3809-1045 12.3 µM -0.58916648581569 0.260182499776926 no 2515 0.277874798390863 782 325925 SGTC_1645 Cervolide 78 µM -0.589307744882431 0.260134618104559 no 2516 0.277827425182974 781 23173 A fragrance. SGTC_2023 5144124 124 µM -0.589750659324653 0.259984515714807 no 2517 0.277678913186382 790 2830192 SGTC_1679 SEC14.276 6.7 µM -0.589896271137858 0.259935178061367 no 2518 0.277630097101184 785 1005053 YMR079W SEC14 SGTC_2465 5809242 33.21 µM -0.589945005905089 0.259918666337942 no 2519 0.277613759799039 829 2731748 SGTC_1493 4348-0038 111 µM -0.590804315912491 0.25962761422723 no 2520 0.277325771434943 810 800424 SGTC_2236 dapsone 200 µM -0.590993512252122 0.259563555195663 no 2521 0.277262383977333 785 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2271 7849410 118.62 µM -0.593300319480798 0.258783161891818 no 2522 0.276490092505308 810 972430 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.593435033526755 0.258737625660505 no 2523 0.276445024471053 793 676296 Flavone; oxidizing agent. SGTC_2019 4016004 108 µM -0.59400074271997 0.258546449128382 no 2524 0.276255808106539 802 45595336 SGTC_2355 9061122 103.12 µM -0.594020937962776 0.258539625673253 no 2525 0.276249054449784 805 5302957 SGTC_1487 3970-0795 2.82 µM -0.596019361656791 0.257864871028631 no 2526 0.275581146165082 785 3765103 SGTC_2353 9059630 146.67 µM -0.596333146571395 0.257759006677521 no 2527 0.275476345914071 780 4779114 SGTC_1587 estradiol valerate 56.1 µM -0.59639519695295 0.257738074871491 no 2528 0.275455624181861 810 13791 A steroid. SGTC_3053 9095903 49.47 µM -0.596714237723693 0.257630464977732 no 2529 0.275349092587559 835 17174018 SGTC_1396 3511-0007 98.6 µM -0.596848106678658 0.257585319001881 no 2530 0.275304398154402 791 X1396 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.597410501164098 0.257395701940619 no 2531 0.27511667218488 777 6312947 SGTC_5 0352-0601 109.883 µM -0.599430907440464 0.256715100059376 no 2532 0.27444278576175 792 762456 SGTC_1159 4092-0538 61.2 µM -0.599604388988757 0.256656704103147 no 2533 0.274384960715696 801 717301 SGTC_263 alizarin 107.927 µM -0.601210746060644 0.256116313901739 no 2534 0.273849813980636 815 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1569 carminic acid 40.6 µM -0.601388433115499 0.256056575154202 no 2535 0.273790650483343 789 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_550 4123-0385 25.7 µM -0.602213735984866 0.255779201966452 no 2536 0.273515936743533 804 5731123 SGTC_1650 st011916 45.8 µM -0.606490445662221 0.254344373682769 no 2537 0.272094562465288 817 242528 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.60768368888877 0.253944796877847 no 2538 0.271698641600416 810 16725076 SGTC_1437 4092-1038 11.6 µM -0.608677650948986 0.253612204259603 no 2539 0.271369061765939 805 3977136 SGTC_9 0092-0002 10.449 µM -0.609144447026418 0.253456087223899 no 2540 0.271214349409868 800 759368 SGTC_3251 9135047 49.47 µM -0.610794206584687 0.252904740332226 no 2541 0.270667914640498 779 17682963 SGTC_2603 homopterocarpin 100 µM -0.613218253484638 0.252095774509289 no 2542 0.269866018422076 806 101795 A weak amylase inhibitor. SGTC_3124 9127567 49.47 µM -0.61337724460302 0.252042762890848 no 2543 0.269813464341633 794 17592030 SGTC_2508 celastrol 40.54 µM -0.614258111500752 0.251749166411362 no 2544 0.269522389067031 775 122724 Celastrol is a natural product and antioxidant. SGTC_347 4534-1311 26.2 µM -0.615253929167521 0.251417473982696 no 2545 0.269193518870282 811 2862016 SGTC_3036 9090181 49.47 µM -0.61565451927573 0.251284108401712 no 2546 0.269061280220636 816 25236586 SGTC_854 0422-0053 192 µM -0.620056826707659 0.249820947523649 no 2547 0.267610187357822 803 3596728 SGTC_2142 5622915 118.518 µM -0.621392125010083 0.249378040452603 no 2548 0.267170826103683 800 5322196 SGTC_981 1488-1094 54.9 µM -0.622389971854962 0.249047335852502 no 2549 0.266842736417077 809 3449522 SGTC_1275 0867-0008 21.1 µM -0.623367790621065 0.248723495411519 no 2550 0.26652142951931 802 3422836 SGTC_640 3381-0960 37.1 µM -0.623527645046695 0.248670575107137 no 2551 0.266468920681274 811 1745025 SGTC_1236 0330-0013 258 µM -0.625318258535325 0.248078196986978 no 2552 0.265881099407739 807 4617066 SGTC_286 k060-0067 22.9 µM -0.625366341145715 0.248062300485406 no 2553 0.26586532394799 788 5985051 SGTC_1359 1582-0056 520 nM -0.625408779611194 0.248048270435491 no 2554 0.265851400674078 821 3661189 SGTC_3115 9123671 49.47 µM -0.625687449024093 0.247956153546717 no 2555 0.265759983585802 812 3286988 SGTC_3009 9080819 71.4286 µM -0.62598029092405 0.247859371479758 no 2556 0.265663934408774 811 17027216 SGTC_1417 3966-0327 90.4 µM -0.626439295652439 0.247707714417745 no 2557 0.265513420932977 809 651118 SGTC_2704 st078022 71.1 µM -0.627424030078853 0.247382521351995 no 2558 0.265190660041737 824 54697681 SGTC_2926 9010726 65.15 µM -0.62814711487519 0.247143879336751 no 2559 0.264953785512041 808 2994293 SGTC_304 1310-0298 97 µM -0.628367459983733 0.247071182612154 no 2560 0.264881624287283 831 1550234 SGTC_2260 7964312 200 µM -0.62949155367499 0.246700497343642 no 2561 0.264513648310748 809 231951 SGTC_2242 6630449 61.2675 µM -0.631108869938134 0.246167688112418 no 2562 0.263984670942176 789 691249 YDR170C SEC7 SGTC_3307 9126885 69.2785 µM -0.631423149229324 0.246064223490932 no 2563 0.263881941872636 797 24824909 SGTC_2385 9074692 200 µM -0.632286804285891 0.245780017762464 no 2564 0.263599742295405 793 17046906 SGTC_2793 7325131 81.82 µM -0.632879774646152 0.245584989191662 no 2565 0.263406078224664 793 4176441 SGTC_2334 9017922 200 µM -0.633142158607868 0.245498717369005 no 2566 0.263320406832442 816 3163164 SGTC_2797 7859098 81.82 µM -0.633792860669172 0.245284836869775 no 2567 0.263108006514202 803 972681 SGTC_1713 st033146 12.748 µM -0.635595684806507 0.244692786759422 no 2568 0.262519991397919 829 674619 SGTC_975 1335-0046 28.5 µM -0.636702783202119 0.244329595709345 no 2569 0.262159230168152 831 16486740 SGTC_1859 st055998 20 µM -0.637475701709448 0.244076206944874 no 2570 0.261907516118476 822 676301 SGTC_438 sphingosine 6.67 µM -0.637862273589894 0.243949528829545 no 2571 0.261781668924747 789 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1155 4088-0394 48.2 µM -0.638174726705465 0.243847165076156 no 2572 0.261679973522926 820 2326248 SGTC_2636 apigenin dimethyl ether 100 µM -0.638598083956043 0.243708504659433 no 2573 0.261542214045441 829 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1856 st057054 55.7 µM -0.638668989434156 0.243685285449392 no 2574 0.261519145205988 828 1266018 SGTC_2722 naftopidil 47.16 µM -0.638986350300443 0.243581374850729 no 2575 0.261415905804836 823 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_236 1509-0011 5.31 µM -0.639327969906691 0.243469548181009 no 2576 0.261304798284753 839 3107280 SGTC_2782 7736369 71.43 µM -0.639428972833492 0.243436490927574 no 2577 0.261271952988489 812 2950836 YOL077C BRX1 SGTC_231 b-estradiol 524 µM -0.639489088540087 0.243416816805913 no 2578 0.261252404876875 808 450 A steroid. SGTC_2251 lansoprazole 556 µM -0.640131258751614 0.243206706794947 no 2579 0.261043634218098 815 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_227 fluconazole 33.516 µM -0.640904217200183 0.242953934607338 no 2580 0.260792457873778 824 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2092 5303694 80.6725 µM -0.641428296196907 0.242782631639925 no 2581 0.260622226794188 810 1963699 SGTC_353 1988-1175 58.3 µM -0.643517144291469 0.242100510763364 no 2582 0.259944296952671 812 2788357 SGTC_2427 5545055 42.75 µM -0.646560869549904 0.241108434452006 no 2583 0.258958095112882 810 5372858 SGTC_1029 k015-0030 64.7 µM -0.646862042849764 0.241010389891558 no 2584 0.258860616845265 811 2208316 SGTC_2006 4011487 200 µM -0.646922410877702 0.240990740171388 no 2585 0.258841080309996 815 45595294 SGTC_1867 st057372 64 µM -0.647182899512652 0.24090596142715 no 2586 0.258756788717384 791 688837 SGTC_1603 st002045 67.8 µM -0.647482937995721 0.240808330880857 no 2587 0.258659716786995 820 5887985 SGTC_957 1187-1561 14.1 µM -0.648457380488804 0.240491402259225 no 2588 0.258344583940224 817 1538454 SGTC_3290 9121031 71.43 µM -0.648922672019846 0.240340150553053 no 2589 0.258194179754145 814 17014854 SGTC_879 0831-1030 162 µM -0.649399119628744 0.240185326073045 no 2590 0.258040216449239 819 1549252 SGTC_701 4424-0219 185 µM -0.649747624996582 0.24007211161507 no 2591 0.257927627641355 818 2911779 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.649798422921663 0.240055611975984 no 2592 0.257911218895373 810 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2228 7354201 200 µM -0.650207318010342 0.239922821563807 no 2593 0.257779157330659 841 753451 SGTC_614 0462-0418 107 µM -0.650283924977831 0.23989794758325 no 2594 0.257754419348184 798 5188303 SGTC_3083 9117465 49.47 µM -0.650714526655215 0.239758159091315 no 2595 0.257615392047545 829 16420915 SGTC_217 ketoconazole 989 nM -0.652087371145224 0.239312782223765 no 2596 0.25717240525324 796 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2319 6033012 152.6 µM -0.652453953157808 0.239193932544794 no 2597 0.257054184315926 817 847246 SGTC_709 3807-1509 243 µM -0.653204689607236 0.238950636720459 no 2598 0.256812163666866 851 1886677 YPL242C IQG1 SGTC_1145 3546-0597 10.2 µM -0.654082382974318 0.238666368838647 no 2599 0.256529365400274 822 875334 SGTC_1588 farnesol 29.9 µM -0.654114397425748 0.238656003477191 no 2600 0.256519053212004 814 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3141 9094609 49.47 µM -0.654699442081405 0.238466626183552 no 2601 0.256330642271871 831 25236309 YDL196W YDL196W SGTC_2776 terbinafine 19.92 µM -0.65516476620411 0.238316060848901 no 2602 0.256180838292997 795 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3026 9090633 49.47 µM -0.655590174070045 0.238178456825726 no 2603 0.25604392469688 815 25236842 SGTC_752 1896-0090 130 µM -0.655918058635129 0.238072427769647 no 2604 0.255938424128076 819 772567 SGTC_2482 5981709 142.65 µM -0.655975456353181 0.238053869551249 no 2605 0.255919958096012 829 877755 SGTC_2333 9017922 200 µM -0.656579725577593 0.237858541260721 no 2606 0.25572559439443 831 3163164 SGTC_838 0109-0203 71.4 µM -0.6575011012841 0.237560878460942 no 2607 0.255429381545373 797 759422 SGTC_36 0335-0881 14.2 µM -0.658556673406194 0.237220113120418 no 2608 0.255090246420323 815 23828853 SGTC_828 2074-0507 139 µM -0.659916369088507 0.236781564980486 no 2609 0.254653749544267 817 X828 SGTC_1177 0983-0204 23.6 µM -0.660306431023073 0.236655839077191 no 2610 0.254528601991151 819 766818 SGTC_403 arphamenine a 50 µM -0.661648649314855 0.236223492089347 no 2611 0.25409821071647 824 5487158 An arginine aminopeptidase inhibitor. SGTC_1879 gemcitabine 100 µM -0.6616835386318 0.236212259563713 no 2612 0.254087028316239 844 60750 A nucleoside analog which inhibits DNA replication. SGTC_463 ikarugamyin 104 µM -0.662118092836066 0.236072380609964 no 2613 0.253947770667519 837 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_814 3342-0569 96 µM -0.662735032101542 0.235873872014528 no 2614 0.253750134546673 827 4346283 SGTC_1978 st071761 42 µM -0.663131459662787 0.235746364632377 no 2615 0.253623181850272 812 5147680 SGTC_2450 5739737 12.93 µM -0.6637775332591 0.23553864230587 no 2616 0.253416353557381 823 2262825 SGTC_2441 5730946 39.09 µM -0.66478684576982 0.235214335433912 no 2617 0.253093418667032 809 1774275 SGTC_1295 1013-0063 9.78 µM -0.665803265929745 0.23488799410311 no 2618 0.252768428549907 819 6826038 SGTC_2231 micatex 6.853 µM -0.666353093711417 0.234711565614894 no 2619 0.252592718271379 823 20737 An antifungal of unknown mechanism. SGTC_2990 9074105 71.4286 µM -0.666403280499265 0.234695465351278 no 2620 0.252576683119186 838 6502001 SGTC_825 1988-2224 89.6 µM -0.667022260806325 0.234496942469744 no 2621 0.252378957173998 818 1180859 SGTC_2357 9067248 200 µM -0.667037568367519 0.234492034119134 no 2622 0.252374068388465 836 9150235 SGTC_2291 7917025 104.35 µM -0.667464142779067 0.234355276423724 no 2623 0.252237853127943 820 2964612 SGTC_920 mycophenolic acid 780.421 nM -0.668007444043768 0.23418116059141 no 2624 0.252064420381365 809 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1125 tnp00248 1.32998 µM -0.669466902245495 0.233713791883034 no 2625 0.251598843488954 830 24207736 SGTC_2511 berberine 10.47 µM -0.670177043219835 0.233486567461129 no 2626 0.251372468193045 838 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_141 0443-0274 32.331 µM -0.671508250775117 0.233060950159548 no 2627 0.250948402557839 793 1627241 SGTC_881 0833-0569 170 µM -0.672066945536721 0.232882451176799 no 2628 0.250770539226927 821 5418700 SGTC_11 0438-0307 1.3 µM -0.672332778513324 0.232797546113523 no 2629 0.250685933382948 828 4011476 SGTC_1001 4048-4355 44.4 µM -0.673494340072781 0.232426753894628 no 2630 0.2503164241759 826 21824233 SGTC_2305 7443522 69.23 µM -0.674639389320239 0.232061554443961 no 2631 0.249952450591786 818 5415886 SGTC_926 2268-1401 59.4 µM -0.674942743963006 0.23196485674432 no 2632 0.249856071187322 834 2931578 SGTC_2344 7990960 76.95 µM -0.675737418680042 0.231711651657247 no 2633 0.249603687068067 835 140813 SGTC_3245 9134821 49.47 µM -0.676107279540421 0.231593856416939 no 2634 0.249486267586601 843 17014901 SGTC_2885 9057732 51.95 µM -0.676116387653447 0.231590956038151 no 2635 0.249483376410373 834 6471414 SGTC_1232 0279-0259 161 µM -0.676279548078432 0.231539002818603 no 2636 0.249431587629544 825 1560000 SGTC_68 0986-0284 82.829 µM -0.676921497167302 0.23133465774084 no 2637 0.24922788192579 814 423278 YIL048W NEO1 SGTC_162 k030-0015 37.8 µM -0.677393281453671 0.231184543629835 no 2638 0.249078229976849 849 1809920 YMR134W ERG29 SGTC_2408 sulbentine 18.36 µM -0.677769932090123 0.231064738530253 no 2639 0.248958789145844 815 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.679106145010404 0.230639995337787 no 2640 0.248535304586651 860 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_2059 5238311 157 µM -0.679409501381678 0.230543627974287 no 2641 0.248439215655698 829 703021 SGTC_620 0109-0052 432 µM -0.681762694065631 0.229796852927314 no 2642 0.247694508621212 840 493037 SGTC_2018 5133068 143 µM -0.681923498017982 0.229745872008374 no 2643 0.247643663081799 845 785362 SGTC_1683 st010134 710 nM -0.682260071105653 0.229639186148146 no 2644 0.247537258122252 845 3818134 SGTC_901 1112-0062 60.1 µM -0.683049395201572 0.229389097608136 no 2645 0.247287815301135 831 1908457 SGTC_29 0299-0004 12.984 µM -0.683074177209319 0.229381248177792 no 2646 0.247279985848036 817 16871 A napthoquinone isolated from Swertia calycina. SGTC_1770 st043884 66.3 µM -0.683089559200199 0.229376376175873 no 2647 0.247275126236766 846 670149 SGTC_475 α-linolenic acid 10 µM -0.683956017238909 0.229102032993571 no 2648 0.247001469802268 818 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2489 cantharidin 73.42 µM -0.684223003243542 0.229017535379621 no 2649 0.246917179360409 830 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2675 theaflavin digallate 100 µM -0.684554215093362 0.228912735420965 no 2650 0.24681263350525 829 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1128 3448-9350 235 µM -0.685008053887998 0.228769178333871 no 2651 0.246669419375908 812 619386 SGTC_3196 9111891 49.47 µM -0.685639237782833 0.228569607964931 no 2652 0.246470315941163 856 18891510 SGTC_2966 9084041 48.03 µM -0.686620392401741 0.2282595766223 no 2653 0.246160987247615 816 17741380 SGTC_2706 st078239 82.5 µM -0.686781478996702 0.228208698077868 no 2654 0.246110221368601 834 15434492 SGTC_3055 9094636 49.47 µM -0.687247967154944 0.228061395665255 no 2655 0.245963240933576 830 25236176 SGTC_2013 4024628 200 µM -0.689050625910853 0.227492675097814 no 2656 0.245395704692051 847 5230760 SGTC_1333 1482-0047 286 µM -0.69074618205943 0.226958474072405 no 2657 0.244862530824044 840 3811116 SGTC_3006 9075424 71.4286 µM -0.69081095659584 0.226938080280104 no 2658 0.244842174603963 828 7465181 SGTC_1391 3442-0225 151 µM -0.692516899589192 0.226401348703509 no 2659 0.244306388393224 824 5227075 SGTC_1916 st067606 49.2 µM -0.692572503761003 0.226383866337756 no 2660 0.244288935409592 815 19590279 SGTC_2244 6635614 200 µM -0.693225424951183 0.226178640099758 no 2661 0.244084047427023 845 836499 SGTC_2259 7964009 200 µM -0.693689327207571 0.226032890211821 no 2662 0.243938530302847 819 313134 SGTC_1316 1272-0050 65.9 µM -0.693933946640534 0.225956056494178 no 2663 0.24386181679238 843 7340392 SGTC_22 0964-0034 14.468 µM -0.695221450964981 0.225551901421195 no 2664 0.243458265607246 846 138402 SGTC_2307 7538926 6.34 µM -0.696451269720542 0.225166236508553 no 2665 0.243073132349503 846 96582 SGTC_799 1310-0557 151 µM -0.696579503823377 0.225126044463545 no 2666 0.243032993200344 847 5354492 SGTC_1443 4112-3303 14 µM -0.696894652718669 0.225027285525391 no 2667 0.242934362221713 844 704433 SGTC_2996 9066192 71.4286 µM -0.699869155286299 0.224096369052208 no 2668 0.242004510870589 827 6472854 SGTC_1945 st075991 56.6 µM -0.700715169401184 0.223831995985095 no 2669 0.241740393671916 826 1084980 SGTC_962 1254-0300 21.5 µM -0.70249621302178 0.223276013025853 no 2670 0.241184881288117 807 7340576 SGTC_665 3914-0008 307 µM -0.705188595842942 0.222437034150893 no 2671 0.240346438676777 843 1069549 SGTC_1300 1094-0077 113 µM -0.70574267961725 0.222264598337007 no 2672 0.240174087095135 846 5532636 SGTC_597 k018-0003 82.8 µM -0.706992594424643 0.2218758939167 no 2673 0.239785539959866 845 6786234 SGTC_2118 5526350 200 µM -0.709873852381229 0.220981347222273 no 2674 0.238891183208133 842 743594 SGTC_524 r073-0010 27.8 µM -0.710746066680881 0.220710957672742 no 2675 0.23862080372049 848 2772106 SGTC_3255 9139072 49.47 µM -0.711336316534813 0.220528085666198 no 2676 0.238437926024766 843 17646060 SGTC_137 0438-0332 85.389 µM -0.712241486690423 0.220247813360172 no 2677 0.238157625403949 855 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2712 st079126 47.7 µM -0.713630885826224 0.219818004460856 no 2678 0.23772772692701 838 3152970 SGTC_1491 4138-0063 26.5 µM -0.716007126345148 0.219084034357675 no 2679 0.236993474298542 836 23883227 SGTC_460 trequinsin 123 µM -0.717093185850009 0.218749043491039 no 2680 0.236658300006439 862 5537 A vasodilator. SGTC_2526 patulin 37.61 µM -0.718305671536894 0.218375405437086 no 2681 0.236284416966814 840 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1915 st067105 30.6 µM -0.718959375822426 0.218174113373268 no 2682 0.236082975229941 847 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3165 9101544 49.47 µM -0.72074204909732 0.21762572695439 no 2683 0.235534118064531 838 5002184 SGTC_260 nsc-65238 3.989 µM -0.721101878586266 0.217515132670933 no 2684 0.235423417659042 849 3246252 SGTC_2153 5569715 200 µM -0.721321992683629 0.217447496175963 no 2685 0.235355714409761 836 2054701 SGTC_2256 7954252 200 µM -0.721732697858999 0.217321327465599 no 2686 0.2352294174155 866 2972920 SGTC_2359 9039622 200 µM -0.722138875241175 0.217196591283151 no 2687 0.235104549589028 854 6463596 SGTC_259 usnic acid 108.925 µM -0.722250017091162 0.217162467072895 no 2688 0.235070388529988 866 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2234 tolnaftate 200 µM -0.723334230251191 0.216829740425293 no 2689 0.234737283774636 851 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2225 6654152 15.4 µM -0.724570535601548 0.216450699164878 no 2690 0.234357770124535 842 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2227 7312221 64.1025 µM -0.724769042817222 0.216389874198352 no 2691 0.234296865216402 867 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2725 haloperidol 53.21 µM -0.724875489662118 0.216357261697053 no 2692 0.234264209381207 838 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1516 st013856 110 µM -0.726469061854308 0.215869373481507 no 2693 0.233775633532608 841 5281404 A mutagen and neurotoxin. SGTC_783 0848-0141 92.7 µM -0.727050115871744 0.215691636667998 no 2694 0.23359762785688 855 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1412 3909-8563 178 µM -0.727596608098753 0.215524549300453 no 2695 0.233430278780461 862 23767530 SGTC_94 0334-0113 514.748 µM -0.727811958525397 0.215458727569282 no 2696 0.233364351567695 846 6795178 SGTC_1703 st026983 48.3 µM -0.728424468660728 0.215271577967844 no 2697 0.23317689468074 832 1104023 SGTC_1648 st011736 69.8 µM -0.728935800685386 0.215115415139312 no 2698 0.233020467089635 846 2855514 SGTC_914 3820-6779 408 µM -0.729536569063743 0.214932022147534 no 2699 0.232836753453561 840 2893481 SGTC_3085 9117376 49.47 µM -0.729824874107249 0.214844045235723 no 2700 0.232748618995059 848 16480349 SGTC_377 3970-0964 33.1 µM -0.730252593497627 0.214713564279337 no 2701 0.232617899922344 838 16481235 SGTC_299 1273-0059 1.44 µM -0.731204831208245 0.214423238123635 no 2702 0.232327024834591 842 2848077 SGTC_1899 st063254 59.6 µM -0.732796092538992 0.213938590940766 no 2703 0.231841402442821 835 3093813 SGTC_1030 k029-0042 36.7 µM -0.733174111443721 0.213823552315732 no 2704 0.231726121504511 851 6080581 SGTC_1056 3448-1962 115 µM -0.734096277934043 0.213543069993441 no 2705 0.231445030933707 853 715507 SGTC_3273 9137859 49.47 µM -0.737100154444485 0.212630911363835 no 2706 0.23053072262732 890 2377234 SGTC_2133 5320837 200 µM -0.737309546662441 0.212567412166027 no 2707 0.230467063984379 860 2841355 SGTC_90 0870-0863 4.608 µM -0.73812092668727 0.212321461902394 no 2708 0.230220484078829 860 1738164 SGTC_1926 methyl fluorone black 53.6 µM -0.738854115721297 0.212099356457201 no 2709 0.229997793536164 807 72721 Reacts with homocysteine. SGTC_3057 9095946 49.47 µM -0.741745659028959 0.211224744708932 no 2710 0.229120725118365 862 24540043 SGTC_1622 st003707 19.4 µM -0.743524500757508 0.210687745836715 no 2711 0.228582096833838 818 10140899 SGTC_830 4076-0286 57.8 µM -0.745105087139057 0.210211269208951 no 2712 0.228104097017215 853 6866659 SGTC_3092 9117248 49.47 µM -0.745788424482993 0.210005469441189 no 2713 0.227897616785444 876 17141857 SGTC_1091 telmisartan 47.6 µM -0.747205263807175 0.20957913930089 no 2714 0.227469833595227 871 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2287 7945887 168.79 µM -0.747669092917215 0.209439682759474 no 2715 0.227329889015926 845 1245853 SGTC_3304 9125678 46.087 µM -0.748367521333424 0.209229793778014 no 2716 0.227119253662584 863 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1608 st001473 40.5 µM -0.748448164673058 0.209205567132602 no 2717 0.227094939949041 862 7292267 SGTC_144 4161-2749 112.381 µM -0.748676225642991 0.209137062636527 no 2718 0.227026188226524 856 797501 YMR168C CEP3 SGTC_343 4130-2827 29.8 µM -0.74929034220752 0.208952661216066 no 2719 0.226841113765756 843 1118244 SGTC_985 1493-0307 8.71 µM -0.750127868030453 0.20870133089874 no 2720 0.226588848372944 870 3278274 SGTC_2266 7929956 200 µM -0.7528923027695 0.207873026549896 no 2721 0.225757316954903 857 2967153 SGTC_3087 9117406 49.47 µM -0.753087197270657 0.207814703886179 no 2722 0.225698758640991 843 42546093 SGTC_2947 9072639 7.68 µM -0.754421472877528 0.207415678231945 no 2723 0.225298090925979 896 16488146 SGTC_184 1494-0393 24.714 µM -0.755890692073536 0.206976821001285 no 2724 0.224857367532417 855 3090647 SGTC_1076 itraconazole 331 nM -0.758146354151264 0.206304122911304 no 2725 0.224181686129642 855 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_632 0781-2353 4.65 µM -0.758762824672936 0.2061205008046 no 2726 0.223997223796946 873 6811515 YHR007C ERG11 SGTC_2908 7930301 100 µM -0.759727093237716 0.205833477872231 no 2727 0.223708865196359 840 2223178 SGTC_484 loperamide 105 µM -0.76034408749206 0.205649948635661 no 2728 0.223524467628343 821 3955 An opioid-receptor agonist. SGTC_163 TUB2.036 7.546 µM -0.761161736486383 0.205406882959046 no 2729 0.223280234771696 859 15992207 YJR013W GPI14 SGTC_1523 st012844 44.7 µM -0.76144087234907 0.205323942244396 no 2730 0.223196891302371 867 4274103 SGTC_3312 9133330 71.43 µM -0.762708471601671 0.204947545961197 no 2731 0.222818638570857 877 17617324 SGTC_1206 3978-0017 132 µM -0.764154007646168 0.204518814801381 no 2732 0.222387735445165 857 3873677 SGTC_1112 tnp00069 1.16933 µM -0.76498397159873 0.204272897388381 no 2733 0.222140544559622 862 145826 SGTC_1318 1280-3875 124 µM -0.766168356704665 0.203922270440901 no 2734 0.221788066974475 884 373245 SGTC_898 1000-0849 28.3 µM -0.766189614508658 0.20391598053033 no 2735 0.22178174348984 867 6751807 SGTC_1768 st044301 37.178 µM -0.767134597693064 0.20363648899001 no 2736 0.221500746714939 895 3931349 SGTC_191 3914-0123 66.505 µM -0.767218103800826 0.203611801920467 no 2737 0.22147592543205 864 3144412 SGTC_1865 st057639 52.2 µM -0.768153128406347 0.203335500709764 no 2738 0.22119810813459 873 688818 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.769595653416009 0.202909671458184 no 2739 0.22076989208679 860 6708561 SGTC_160 3453-0671 289.699 µM -0.770904239419423 0.202523841764129 no 2740 0.220381847054951 873 5322268 SGTC_2809 7964133 12.99 µM -0.772579295823788 0.202030600750555 no 2741 0.219885700746715 881 1253665 SGTC_3300 9124615 50.48 µM -0.773328331382777 0.201810270821419 no 2742 0.219664046412332 862 24824903 SGTC_1692 fluoroquinolonic acid 71 µM -0.773416506407667 0.201784343475013 no 2743 0.219637962133848 862 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2499 avocadenofuran 51.48 µM -0.774769239637913 0.201386830327212 no 2744 0.219238014354136 880 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_909 3448-9333 149 µM -0.774881365306253 0.201353902242319 no 2745 0.219204882187144 870 3344074 SGTC_1146 3579-1023 7 µM -0.774918447546426 0.201343012964763 no 2746 0.219193925338718 882 X1146 SGTC_1765 st044815 90.4 µM -0.775641349385658 0.201130801848622 no 2747 0.218980389337619 873 645695 SGTC_3161 9100388 49.47 µM -0.77676189414434 0.200802126074357 no 2748 0.218649631266589 865 25236368 SGTC_2155 5570423 76 µM -0.777474768361657 0.200593195212861 no 2749 0.218439357569927 882 797402 SGTC_1326 1431-2094 10.8 µM -0.778488439732479 0.20029633087441 no 2750 0.218140559557464 881 616278 SGTC_1596 piperlongumine 63 µM -0.78004272616107 0.199841654745546 no 2751 0.21768286327116 853 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1016 4226-1401 38 µM -0.781238929132144 0.199492152024655 no 2752 0.217330990726505 863 2901613 SGTC_2001 4023502 57.655 µM -0.781707874071165 0.19935523765883 no 2753 0.217193136542997 865 108941 YCR052W RSC6 SGTC_381 3461-2219 42.7 µM -0.781812490549061 0.199324701284596 no 2754 0.217162389677716 881 2883159 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.782646851158193 0.199081261621541 no 2755 0.216917260452706 883 75037 A free radical scavenger. SGTC_590 k048-0076 22.4 µM -0.783185036871471 0.198924331371724 no 2756 0.216759230203244 876 6832814 SGTC_235 0330-0087 5 mM -0.783196995452053 0.19892084520109 no 2757 0.216755719499747 872 46494818 YHR062C RPP1 SGTC_678 1218-2179 85.9 µM -0.783490036198901 0.198835429341666 no 2758 0.216669701239634 886 6820081 YOR116C RPO31 SGTC_1864 st057645 30.4 µM -0.784866546586855 0.198434498423904 no 2759 0.216265908990352 864 688666 SGTC_1504 k297-0033 30 µM -0.785406760078715 0.198277285876136 no 2760 0.2161075592558 816 4388117 SGTC_831 k061-1017 217 µM -0.785604613968883 0.198219725391203 no 2761 0.216049580265782 882 1240153 SGTC_3324 9138759 60.749 µM -0.785697681494635 0.198192653284272 no 2762 0.216022310927893 874 45595710 SGTC_2842 9000675 19.48 µM -0.786415874654987 0.197983815516341 no 2763 0.215811943136202 850 2989072 SGTC_2697 mebhydrolin 72.4 µM -0.788387775743608 0.197411105625739 no 2764 0.215234959466477 884 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2698 st077697 67.5 µM -0.788676910558408 0.197327214938766 no 2765 0.215150433151653 867 3154499 SGTC_2145 5634607 200 µM -0.790177515206587 0.19689217020146 no 2766 0.214712052687093 878 308662 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.790586836606406 0.196773603499266 no 2767 0.214592565381275 877 61125 An anti-inflammatory. SGTC_1323 1348-1351 11.2 µM -0.791991136223971 0.196367153685964 no 2768 0.214182922290325 843 6989654 SGTC_2883 9059145 45.46 µM -0.792302573649712 0.196277082594677 no 2769 0.214092135700732 889 16476510 SGTC_1827 berberine 7.24 µM -0.79356921443824 0.195911014465173 no 2770 0.213723130254756 837 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_301 4119-0100 24.5 µM -0.796349662552813 0.195108899377467 no 2771 0.212914413708826 886 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2264 7948757 110.76 µM -0.800752912060072 0.193842722914695 no 2772 0.211637352014774 862 2971411 SGTC_1208 2323-2347 50.3 µM -0.800772330214674 0.193837150242594 no 2773 0.211631730171967 865 5412760 SGTC_1265 0819-1001 68.8 µM -0.801222211893037 0.193708069378474 no 2774 0.211501507250701 878 3106768 SGTC_720 r052-1644 49.9 µM -0.801275586963841 0.193692758385342 no 2775 0.211486060396586 867 1422863 YOR257W CDC31 SGTC_261 5-fluorouridine 15.376 µM -0.801609879598713 0.193596881109795 no 2776 0.211389330453922 859 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_482 fipronil 114 µM -0.802293992825534 0.193400763283968 no 2777 0.211191458238429 865 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1840 st055363 71 µM -0.802323251360691 0.193392378311498 no 2778 0.21118299795026 889 676033 SGTC_3123 9126162 49.47 µM -0.80361838577311 0.193021438215313 no 2779 0.210808700749473 854 25239884 SGTC_1515 3460-0031 42.1 µM -0.804598258858748 0.19274108117692 no 2780 0.210525773607829 863 2876596 SGTC_1218 1348-1416 30.7 µM -0.806613384993079 0.192165304523991 no 2781 0.209944629879414 860 6787668 SGTC_2154 5570129 200 µM -0.807967114120524 0.191779098626046 no 2782 0.209554756878832 904 673366 SGTC_983 1491-0821 12.2 µM -0.80809128479034 0.191743697739608 no 2783 0.20951901715217 866 46495113 SGTC_3332 9141069 11.198 µM -0.810321190210276 0.191108636148295 no 2784 0.208877799802277 875 17332883 SGTC_743 1275-0778 158 µM -0.810769890259489 0.190981005533583 no 2785 0.208748914349079 877 2849257 YMR203W TOM40 SGTC_226 1,3-diallylurea 8.28947 mM -0.811295276350732 0.190831628400865 no 2786 0.208598061033984 872 74537 YKL182W FAS1 SGTC_1688 st021091 57.6 µM -0.811807135584648 0.190686166169989 no 2787 0.208451153489973 886 3656366 SGTC_214 4373-3496 70 µM -0.812078338588954 0.190609122189647 no 2788 0.208373340872573 881 3779166 SGTC_1366 1683-0113 21.9 µM -0.814257914469521 0.189990637312228 no 2789 0.207748606981117 884 708623 SGTC_2253 7938677 135.83 µM -0.816048251162934 0.189483528374127 no 2790 0.207236269717697 885 2301972 SGTC_3140 9094243 49.47 µM -0.816279569830963 0.18941806868316 no 2791 0.207170128244793 886 19291112 SGTC_3121 9125696 49.47 µM -0.816550292344223 0.189341475977062 no 2792 0.207092735800575 903 1235365 SGTC_583 1488-1091 88.9 µM -0.818465573939737 0.188800149960066 no 2793 0.206545695900189 903 4303273 SGTC_59 0330-0160 1.33 µM -0.818957066701578 0.188661390729686 no 2794 0.206405454592773 886 4293482 SGTC_1035 k081-0041 55.2 µM -0.819571582182726 0.188487987942407 no 2795 0.206230189688735 861 731709 SGTC_1619 st003326 88.7 µM -0.820286978107072 0.188286242764877 no 2796 0.206026264016152 825 2849032 SGTC_1986 st071812 45 µM -0.821357537822643 0.187984588604682 no 2797 0.205721321358577 881 11838594 SGTC_2760 etidronate 98.04 µM -0.821515731135688 0.187940039412634 no 2798 0.205676283646738 872 3305 A chelator and antioxidant. SGTC_2376 9072922 81.32 µM -0.821875753892427 0.187838676855357 no 2799 0.205573806812969 890 17087968 SGTC_2428 5615643 7.78 µM -0.822077575829291 0.187781869696216 no 2800 0.205516373502576 874 2253075 SGTC_1276 0871-0068 94.2 µM -0.823462511769146 0.187392335748098 no 2801 0.205122513574642 872 3414906 SGTC_904 1141-0088 396 µM -0.824487797221547 0.187104280888654 no 2802 0.204831223302704 891 1378119 SGTC_2400 5203494 178.7 µM -0.82501354467352 0.186956677959386 no 2803 0.204681950488944 887 6777674 SGTC_688 0527-0193 473 µM -0.82505206206195 0.186945867084665 no 2804 0.204671016986541 911 4007154 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.825544600071181 0.186807657992383 no 2805 0.204531236333539 873 5379071 SGTC_944 3370-0224 231 µM -0.826097378786452 0.186652620336465 no 2806 0.204374427243617 883 4580514 SGTC_1478 0453-0656 35.7 µM -0.826757922593475 0.186467462349064 no 2807 0.204187141858727 890 5258496 SGTC_1548 st061468 90.8 µM -0.829865290717666 0.185597958758554 no 2808 0.203307475527755 881 390799 SGTC_1449 4112-4002 201 µM -0.830089809185976 0.185535231622736 no 2809 0.203244004213018 888 2059539 SGTC_1100 amiodarone 5.07 µM -0.830838321159034 0.185326203524523 no 2810 0.203032485520014 861 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_715 0868-0130 184 µM -0.83149945504952 0.185141698131451 no 2811 0.202845767982992 918 2876258 SGTC_62 0180-0423 3.232 µM -0.832059534509148 0.184985483720829 no 2812 0.202687670540959 890 30102 YGL099W LSG1 SGTC_762 1165-0429 115 µM -0.835060028635688 0.184149997011121 no 2813 0.201841955340436 879 5967793 SGTC_2091 4-phenylthiadiazole 200 µM -0.835145068943963 0.184126351841185 no 2814 0.201818016824857 883 270010 SGTC_3211 9128781 49.47 µM -0.835745980943788 0.183959324156844 no 2815 0.201648910890245 890 17194361 SGTC_1767 st044992 70.3 µM -0.836058385319043 0.183872526467705 no 2816 0.201561029008596 883 9600693 SGTC_349 k015-0014 24 µM -0.837463035102764 0.183482577155508 no 2817 0.201166173267607 891 2196908 SGTC_775 4577-0580 57.3 µM -0.837984630449477 0.183337906750191 no 2818 0.201019667771651 889 2006902 SGTC_2957 9076800 11.52 µM -0.838426182424703 0.183215492890063 no 2819 0.200895694864628 910 16459615 SGTC_2389 9091542 195.52 µM -0.839554825317266 0.182902824818662 no 2820 0.200579018560926 869 3626624 YOL127W RPL25 SGTC_3138 9097216 49.47 µM -0.839763385421053 0.182845083863356 no 2821 0.200520533285122 887 25237486 SGTC_2881 9058953 51.95 µM -0.840590008474248 0.182616340879661 no 2822 0.200288829027177 853 17122249 SGTC_659 k018-0002 107 µM -0.842059127757426 0.182210247700632 no 2823 0.199877428894715 904 6797879 YHR007C ERG11 SGTC_1816 st051957 91.6 µM -0.842367354652924 0.182125119468309 no 2824 0.199791180100192 915 674121 SGTC_1982 st072467 71.9 µM -0.844246907350604 0.181606549827479 no 2825 0.199265723779979 897 3163533 SGTC_540 1187-0821 17.3 µM -0.844340363701348 0.181580789305472 no 2826 0.199239618434904 891 847520 SGTC_2719 novobiocin 32.65 µM -0.845204565564966 0.181342687087681 no 2827 0.198998316840698 909 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2682 pyrogallin 40.03 µM -0.845590194262122 0.181236502974219 no 2828 0.198890698823252 869 822798 An ATP competetive kinase inhibitor. SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.848051804420412 0.180559608583301 no 2829 0.198204560363585 874 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2601 securinine 100 µM -0.848216426148619 0.180514397479772 no 2830 0.198158725454248 893 442872 A GABA receptor antagonist. SGTC_544 k015-0020 52.4 µM -0.850707690320798 0.179831072914193 no 2831 0.197465875083327 888 3008304 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.851341639422602 0.179657447777904 no 2832 0.197289800329553 889 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2865 9030313 51.95 µM -0.852750418675652 0.179271990473021 no 2833 0.196898862299419 893 42562754 SGTC_897 1000-0139 31.4 µM -0.853388320477496 0.179097624804765 no 2834 0.19672199811057 892 6151020 SGTC_789 1309-1135 70.6 µM -0.854684896886709 0.178743544328368 no 2835 0.196362806952112 873 3092424 SGTC_965 1291-5240 308 µM -0.855133833485716 0.17862104756476 no 2836 0.196238530551015 910 2834598 SGTC_1183 1254-0324 198 µM -0.856548250813349 0.178235455660101 no 2837 0.195847297882769 867 5799357 SGTC_703 3875-0075 71.8 µM -0.856958696943827 0.178123660012847 no 2838 0.195733855746007 918 2850814 SGTC_1651 st011928 86.1 µM -0.857554771651012 0.177961382340427 no 2839 0.195569179250598 907 720198 SGTC_2206 7254556 146.969 µM -0.85771870009998 0.177916770178747 no 2840 0.195523905784343 874 4398905 SGTC_1653 st012112 65 µM -0.857991514924594 0.177842540869059 no 2841 0.195448574384826 884 720429 SGTC_1741 st038134 10.228 µM -0.859044374299869 0.177556254940183 no 2842 0.195158017352854 900 1272587 SGTC_2945 9067681 61.76 µM -0.860424172006086 0.177181510928317 no 2843 0.194777633031507 914 16456930 SGTC_448 monastrol 171 µM -0.862047791821578 0.176741186714567 no 2844 0.194330609552172 905 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1457 k015-0032 57.3 µM -0.862184218090419 0.17670421956799 no 2845 0.194293076430893 897 4302660 SGTC_1710 st031758 61.5 µM -0.863456643496257 0.176359668519637 no 2846 0.193943223794061 883 5394341 SGTC_868 0527-0199 213 µM -0.864252801159187 0.176144298973819 no 2847 0.193724516078844 891 2849450 SGTC_2007 4011539 71.82 µM -0.865019248395444 0.175937123777131 no 2848 0.193514112057896 892 45595301 SGTC_3070 9117005 49.47 µM -0.865185805021558 0.175892122959114 no 2849 0.193468407609875 907 8779016 SGTC_248 streptozotocin 5.23457 mM -0.865885237640435 0.175703227539472 no 2850 0.193276549698286 900 5300 DNA alkylating agent. SGTC_2300 7976697 71.57 µM -0.867963015222626 0.175142841530963 no 2851 0.192707289948066 879 2236109 SGTC_3288 9119690 36.221 µM -0.868182414398189 0.17508373482651 no 2852 0.192647239852657 924 17595618 YKL019W RAM2 SGTC_2811 7967822 32.47 µM -0.86864040025695 0.174960393035625 no 2853 0.192521924850326 889 2232244 SGTC_1612 st002233 45.4 µM -0.871034150257446 0.174316621255989 no 2854 0.191867753435621 882 1035021 SGTC_2214 7179297 48.276 µM -0.872932947316748 0.173807033275541 no 2855 0.191349813327556 887 769744 SGTC_1893 st059353 36.1 µM -0.876442682227933 0.172867608413567 no 2856 0.190394711701733 932 3112488 SGTC_952 1185-0122 232 µM -0.881252056156759 0.171585584260631 no 2857 0.189090704725231 889 678600 SGTC_3134 9127454 49.47 µM -0.881947547246003 0.171400692785176 no 2858 0.188902586512491 915 24262820 SGTC_2779 methotrexate 400 µM -0.883480157807768 0.170993708600432 no 2859 0.188488449286612 893 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2009 4012297 12.05 µM -0.883655114767936 0.170947288187622 no 2860 0.188441208597233 896 45595307 SGTC_483 fpl-64176 144 µM -0.88548047795765 0.170463455078417 no 2861 0.187948772058132 910 3423 SGTC_1476 4112-3294 3.34 µM -0.88609779114258 0.170300027884848 no 2862 0.18778241660947 870 704369 SGTC_1719 st032227 49.2 µM -0.888134750642699 0.169761476524696 no 2863 0.187234135940858 892 3125804 SGTC_2061 5245884 80.95 µM -0.889099119577416 0.169506888566539 no 2864 0.186974906027649 911 573863 SGTC_1223 0764-0573 147 µM -0.889394436068455 0.169428975700724 no 2865 0.186895567077529 890 1609797 SGTC_903 1134-0042 114 µM -0.896466548344866 0.167570019631243 no 2866 0.185001819305343 891 701009 SGTC_1704 st028805 70.8 µM -0.898201409846641 0.167116013107283 no 2867 0.184539090952734 895 2876101 SGTC_2662 daunorubicin 22.37 µM -0.899237478817086 0.166845256481117 no 2868 0.184263090603026 863 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2112 5488546 200 µM -0.899684478414666 0.166728529197177 no 2869 0.184144092906794 921 600757 SGTC_412 gemfibrozil 100 µM -0.902128280729878 0.166091298450589 no 2870 0.183494363682032 882 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_37 0566-0070 1.56 µM -0.903862968084493 0.165639928282292 no 2871 0.183034033797902 901 1626686 SGTC_2487 5918373 44.05 µM -0.906067554079718 0.165067435011309 no 2872 0.18245004874904 891 2876279 SGTC_2596 sinensetin 100 µM -0.907773831957167 0.164625224306409 no 2873 0.181998863290712 924 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2216 7189485 200 µM -0.911085050468494 0.1637692585709 no 2874 0.181125281322097 882 731273 SGTC_2962 9082311 13.18 µM -0.912511588077164 0.163401383781131 no 2875 0.180749736098516 908 16459453 SGTC_2339 9000433 200 µM -0.91422052076551 0.16296139232363 no 2876 0.180300491740143 910 2988954 SGTC_2702 st077768 96.8 µM -0.914315372678379 0.162936993797746 no 2877 0.180275577603202 882 6484119 SGTC_1766 st045414 44.774 µM -0.914422067168289 0.162909551873135 no 2878 0.180247555435383 898 253960 SGTC_950 1165-0508 94.1 µM -0.915270403892814 0.16269146580158 no 2879 0.180024846146797 913 6148369 SGTC_1244 0416-0015 52.5 µM -0.915590343469458 0.162609266708366 no 2880 0.179940899013386 904 96201 SGTC_931 2812-0076 566 µM -0.915771661728634 0.162562694295463 no 2881 0.179893334857855 914 3450959 SGTC_1748 st037455 53.6035 µM -0.917317997851832 0.162165863542719 no 2882 0.179488014460627 903 580690 SGTC_2457 5731572 11.68 µM -0.91827282777933 0.161921144188873 no 2883 0.179238024567602 900 2865357 SGTC_648 0375-0473 33.3 µM -0.918955934295281 0.161746214240978 no 2884 0.17905931069073 914 1713139 SGTC_2005 4024620 188 µM -0.922730764529119 0.160781777159104 no 2885 0.178073764664486 909 236743 SGTC_2988 9073640 71.4286 µM -0.922964766043071 0.160722115606879 no 2886 0.178012783499076 909 9102229 SGTC_1283 0922-0125 16.4 µM -0.924761879040921 0.160264401560409 no 2887 0.177544891969844 885 3360884 SGTC_3233 9132340 49.47 µM -0.926932372358152 0.159712726769335 no 2888 0.176980824007693 936 17682950 SGTC_2773 thioridazine 9.09 µM -0.928329138973448 0.159358368153315 no 2889 0.176618431706505 917 5452 An antipsychotic. SGTC_840 0245-0196 390 µM -0.929578560685517 0.159041827364962 no 2890 0.176294666065695 899 3827528 SGTC_2232 chlorophetanol 41.5365 µM -0.930874166970837 0.158714021095586 no 2891 0.175959329415908 908 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1955 wogonin 32.4 µM -0.931228012435258 0.158624570373843 no 2892 0.175867815259339 894 5281703 A flavanone. SGTC_776 4476-4378 112 µM -0.931359660331818 0.158591298749867 no 2893 0.175833775192401 938 2892008 SGTC_2095 5432005 200 µM -0.93250471411484 0.158302100147898 no 2894 0.175537875788234 927 783734 SGTC_1485 3909-9022 254 µM -0.936358642248564 0.157331282985212 no 2895 0.174544282149106 930 714516 SGTC_1715 st032160 10.2275 µM -0.936618833630358 0.157265881258995 no 2896 0.174477330324009 897 5289825 SGTC_1215 3852-0577 11.2 µM -0.938438644342861 0.156808953264671 no 2897 0.17400951708589 897 2884876 SGTC_1897 st060201 15 µM -0.939476903146663 0.156548653372813 no 2898 0.173742972648807 910 611878 SGTC_2936 9038235 15.59 µM -0.941005208973923 0.156166012598111 no 2899 0.173351094897521 897 4749415 SGTC_1669 st015249 58.4 µM -0.94202331319708 0.155911452886616 no 2900 0.173090352097178 931 722793 SGTC_560 2332-1943 155 µM -0.94225423561933 0.155853752726035 no 2901 0.173031246208945 901 21177716 SGTC_1638 st008370 60.6 µM -0.942649672744518 0.155754978278807 no 2902 0.172930061725227 887 24207134 SGTC_2591 skatole 100 µM -0.94571908963612 0.154989686537755 no 2903 0.172145941594714 922 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3122 9126309 49.47 µM -0.94680491894097 0.154719554441913 no 2904 0.171869097397902 936 17591206 SGTC_642 0335-0876 158 µM -0.94781082140626 0.154469584250108 no 2905 0.171612885262566 919 6812350 SGTC_2655 perillic acid 100 µM -0.949419795738614 0.154070303988307 no 2906 0.171203573079576 924 5702197 An apoptosis inducer. SGTC_3145 9085516 49.47 µM -0.949767682378454 0.153984062902385 no 2907 0.171115155217334 920 25236195 SGTC_3169 9102970 49.47 µM -0.952062039568753 0.153416091955228 no 2908 0.170532759641002 940 17027839 SGTC_2222 6885208 172.143 µM -0.952575110527575 0.15328927071028 no 2909 0.170402696466714 923 609514 SGTC_1189 1431-2119 7.28 µM -0.952812536705814 0.153230607054282 no 2910 0.170342530584412 908 3107275 SGTC_2653 dihydrofissinolide 100 µM -0.952938843571194 0.153199405006362 no 2911 0.170310528859274 930 6857746 SGTC_2795 7780010 54.55 µM -0.954145748769847 0.152901471134329 no 2912 0.170004935697377 920 953673 SGTC_1852 st056254 31.4 µM -0.955314903156235 0.152613222928872 no 2913 0.169709236567606 895 442583 SGTC_17 0960-0276 49.807 µM -0.955551727367349 0.152554879236071 no 2914 0.169649379878079 920 6821114 SGTC_1376 2910-0861 41.3 µM -0.95711529391288 0.152170052534099 no 2915 0.169254532500563 921 1112859 SGTC_2917 7979103 53.79 µM -0.96281856697177 0.150771824566715 no 2916 0.167819290699388 934 2980565 SGTC_2701 st077767 14.721 µM -0.96601593312426 0.14999170440971 no 2917 0.167018104167719 910 5721188 SGTC_180 1486-1293 102.781 µM -0.966466416997455 0.149882008290024 no 2918 0.16690542182419 913 4140536 SGTC_3279 9140807 49.47 µM -0.966796404899342 0.149801687781164 no 2919 0.166822911014029 941 45595718 SGTC_2728 chlorpromazine 9.18 µM -0.972435621920284 0.148433515392979 no 2920 0.165416938828401 953 2726 A thorazine and dopamine antagonist. SGTC_1131 3454-3128 32.3 µM -0.974287127995062 0.147986135808503 no 2921 0.164956997029427 901 710982 SGTC_3151 9099821 49.47 µM -0.974367267842554 0.147966792009519 no 2922 0.164937107808467 933 17174189 SGTC_2882 9058044 58.44 µM -0.974376917629305 0.147964462901202 no 2923 0.16493471301547 907 18076804 SGTC_1431 4049-0260 9.09 µM -0.975424270574029 0.1477118157844 no 2924 0.164674924698116 932 3854841 SGTC_3023 9089636 49.47 µM -0.976687283922043 0.147407530582881 no 2925 0.164361996203012 945 17249241 SGTC_1459 k035-0031 35.7 µM -0.977052734903834 0.147319564530586 no 2926 0.164271522782067 895 3877128 YMR208W ERG12 SGTC_118 0083-0097 135.343 µM -0.977639138123714 0.147178487596681 no 2927 0.164126416483439 941 5207356 SGTC_512 prima-1 270 µM -0.977976585002195 0.147097345666881 no 2928 0.164042952478499 923 322968 A re-activator of the apoptotic function of mutant p53. SGTC_82 0054-0107 293.755 µM -0.978548890057808 0.146959798703722 no 2929 0.163901461686944 913 3104697 SGTC_3171 9103192 49.47 µM -0.980908658636294 0.146393566670046 no 2930 0.163318893606395 931 13018434 SGTC_1395 3486-0190 4.35 µM -0.98174395865874 0.146193485929417 no 2931 0.163113001603746 934 6748079 SGTC_2002 4023503 131 µM -0.985829103700539 0.145217611094977 no 2932 0.162108490751751 944 4736863 YCR052W RSC6 SGTC_681 1642-0006 26.6 µM -0.987661873346349 0.14478121981443 no 2933 0.161659136434017 956 4446530 SGTC_2217 6934799 96.0675 µM -0.987757041839776 0.144758583882684 no 2934 0.161635825432526 924 675606 SGTC_1186 1319-0216 26 µM -0.989348392584114 0.144380432473654 no 2935 0.161246357439915 931 4565136 SGTC_633 0437-0093 97.7 µM -0.991950294392462 0.143763579925531 no 2936 0.16061088652519 926 2831118 SGTC_2313 7726885 200 µM -0.994035986821833 0.143270394882557 no 2937 0.160102673878857 927 726423 SGTC_1940 st075990 51.1 µM -0.995182759340464 0.142999715240313 no 2938 0.159823692696195 959 1084979 SGTC_2755 lomerizine 42.69 µM -0.997245583345146 0.14251368477043 no 2939 0.159322660016989 912 3949 A calcium channel blocker. SGTC_246 cycloheximide 667 µM -0.997922607702129 0.142354412066701 no 2940 0.159158444169948 914 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_430 0958-0115 16.4 µM -0.998096120729135 0.142313611822874 no 2941 0.159116375520211 930 6833180 SGTC_2168 5727979 200 µM -0.999285748250014 0.142034093211897 no 2942 0.158828143666241 926 695210 SGTC_1042 0350-0096 82 µM -1.00024840342214 0.141808176954367 no 2943 0.158595155040742 930 3122515 SGTC_2245 6637752 200 µM -1.00036857319037 0.141779992564916 no 2944 0.158566086444945 943 681890 SGTC_2836 9010338 19.48 µM -1.00216247543209 0.141359705157816 no 2945 0.158132563947808 931 2994051 SGTC_2812 7970281 58.44 µM -1.00246442717488 0.141289045002576 no 2946 0.15805966949434 961 2233435 SGTC_591 4299-0174 154 µM -1.00569371245699 0.140534852679615 no 2947 0.157281464329084 966 5509088 SGTC_3353 9151644 39.2805 µM -1.00721244831323 0.140181101914453 no 2948 0.156916346120308 926 4909158 SGTC_1892 st058411 7.36 µM -1.00765729625906 0.140077600568495 no 2949 0.156809506216812 940 3934738 SGTC_1729 st035615 45.989 µM -1.00802921411977 0.139991107491596 no 2950 0.156720218808042 917 17385451 SGTC_1682 st012968 530 nM -1.00841616129582 0.139901157731076 no 2951 0.156627358791511 926 24207270 SGTC_46 0329-0187a 2.197 µM -1.00860717475719 0.139856769216474 no 2952 0.156581532522839 919 46494817 SGTC_2132 5317594 122.667 µM -1.00979633192385 0.13958064316704 no 2953 0.156296438950531 937 794577 SGTC_1027 k015-0025 8.67 µM -1.01178127770235 0.139120558885512 no 2954 0.155821321829839 934 3598955 SGTC_970 1315-0089 19.5 µM -1.01232922598256 0.138993733698836 no 2955 0.155690332685251 916 6811083 YLR033W RSC58 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.01285786260327 0.138871452906617 no 2956 0.155564028912208 933 23665772 A membrane-active detergent. SGTC_677 0929-0063 136 µM -1.01324026065152 0.138783044745828 no 2957 0.155472707129452 964 1539583 SGTC_1591 genipin 88.4 µM -1.01498931726372 0.138379161918406 no 2958 0.155055459904946 951 442424 A DNA cross-linking agent. SGTC_122 0236-0016 402.397 µM -1.01670635054482 0.13798345370872 no 2959 0.154646571895143 926 6808838 SGTC_77 0828-0286 12.516 µM -1.01710899094584 0.137890772858827 no 2960 0.15455079181611 936 745345 SGTC_2838 9002687 71.43 µM -1.0201911281401 0.137182725080005 no 2961 0.153818912201611 942 6457060 SGTC_1810 st050138 53 µM -1.02294866735799 0.136551354423751 no 2962 0.15316605859 950 3444541 SGTC_2343 7990716 14.84 µM -1.02434090105959 0.136233342458363 no 2963 0.152837142765837 950 6456862 SGTC_2903 5923464 63.88 µM -1.02601867369303 0.135850781966375 no 2964 0.152441391042306 938 2876576 SGTC_627 1391-0720 175 µM -1.02688823559572 0.135652796882093 no 2965 0.152236547261065 958 997839 SGTC_568 1193-0097 7.48 µM -1.0281087533413 0.135375238432897 no 2966 0.151949336782572 890 3646150 SGTC_871 0574-0004 149 µM -1.02888506298736 0.135198900191761 no 2967 0.151766844115421 948 9551173 SGTC_171 k064-0041 9.68 µM -1.03106957409539 0.134703535230988 no 2968 0.151254097306308 915 53325 SGTC_344 k064-0035 6.43 µM -1.03113210021112 0.134689375018532 no 2969 0.151239438206064 909 5088750 SGTC_613 3914-0030 117 µM -1.03234367754355 0.134415192256063 no 2970 0.150955573338848 902 1145395 SGTC_1389 3405-0187 19 µM -1.03255912518607 0.134366476115249 no 2971 0.150905132484913 921 799890 SGTC_2202 7226349 200 µM -1.0346855773684 0.133886301779542 no 2972 0.150407886857064 932 844334 SGTC_892 0929-0076 29 µM -1.03778389432444 0.13318878379928 no 2973 0.149685338312056 930 5751038 SGTC_2931 9014674 55.67 µM -1.03840336775735 0.133049623489161 no 2974 0.14954115116472 955 2996810 SGTC_1847 st056231 15 µM -1.03903184383167 0.132908543108634 no 2975 0.149394963335674 922 5393180 SGTC_322 k048-0136 19.3 µM -1.04177305263738 0.132294400810312 no 2976 0.148758455239645 957 6823282 SGTC_375 3970-0961 9.27 µM -1.04197444202657 0.132249358652735 no 2977 0.148711764245188 922 2898222 SGTC_1873 rapamycin 2 nM -1.04223767003969 0.132190501791256 no 2978 0.148650751085246 918 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1302 1159-0335 255 µM -1.0427396714246 0.132078306106169 no 2979 0.148534439457881 932 649284 SGTC_2098 5376439 882.5 nM -1.04477350300739 0.131624423354765 no 2980 0.148063831988729 925 2844116 SGTC_758 0868-0029 16 µM -1.04523048784224 0.13152258800511 no 2981 0.147958227900101 912 762687 SGTC_3267 9137951 49.47 µM -1.04535100720963 0.131495740310468 no 2982 0.147930385624834 980 16643986 SGTC_1949 st076024 69.1 µM -1.05078896531384 0.130288279652783 no 2983 0.146677762462974 947 2921930 SGTC_1104 tacrolimus 29.8 µM -1.05160696860741 0.130107313582916 no 2984 0.146489954634737 919 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1184 1269-1718 139 µM -1.05200050792238 0.130020313268749 no 2985 0.146399658298225 922 5403821 SGTC_660 4031-1742 102 µM -1.05342836090522 0.129704993845309 no 2986 0.146072355798076 902 6738706 SGTC_2279 7948423 32.93 µM -1.05374707311589 0.129634683504729 no 2987 0.145999365504818 928 1247112 SGTC_364 0083-0097 67.7 µM -1.05589749962429 0.129160973042228 no 2988 0.14550752330251 978 5207356 SGTC_2587 piperic acid 92.2 µM -1.05879671837755 0.128524215184137 no 2989 0.144846184256065 936 5370536 SGTC_2301 7769476 200 µM -1.06252502045163 0.127708572152202 no 2990 0.143998702764448 941 977820 SGTC_2161 5662504 8.5105 µM -1.06365137499518 0.127462868075187 no 2991 0.143743329860675 905 2859334 SGTC_451 chloral hydrate 100 µM -1.06577894645634 0.126999654933817 no 2992 0.143261790124129 954 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1373 2887-0003 58.5 µM -1.06630454989755 0.126885401674964 no 2993 0.143142996708869 964 776948 SGTC_853 0419-0306 21 µM -1.06750404401616 0.126624929192372 no 2994 0.142872144243414 945 762713 SGTC_392 N-ethylmaleimide 8.33 µM -1.06786948308179 0.126545647451161 no 2995 0.142789694947845 927 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1175 0741-0056 27.6 µM -1.06856231107199 0.126395433853193 no 2996 0.142633469424427 944 765927 SGTC_3326 9140064 16.379 µM -1.06881863368432 0.126339891466936 no 2997 0.142575700634695 959 1868434 SGTC_1231 0242-0792 125 µM -1.07300129097953 0.125435956626917 no 2998 0.141635268450312 952 3707635 SGTC_2635 hydroquinidine 100 µM -1.07763902017638 0.124438962670334 no 2999 0.140597440792939 934 442912 An experimental heart treatment. SGTC_1747 st037496 66.6 µM -1.07976481508239 0.123983827670376 no 3000 0.140123461483923 949 723305 SGTC_2953 9074162 66.49 µM -1.08084006518233 0.123754059632177 no 3001 0.139884131482568 903 16451992 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.08106481365302 0.123706071273614 no 3002 0.139834141919358 984 4620898 SGTC_1657 st012939 43.4 µM -1.08422247560898 0.123033223584647 no 3003 0.139133084318615 918 24207257 SGTC_1407 3909-7909 12.3 µM -1.08711387965362 0.122419365075073 no 3004 0.138493242284114 925 4411780 SGTC_309 k408-0051 1.48 µM -1.08938886299412 0.121937888804281 no 3005 0.13799122026001 928 3640463 SGTC_3104 9120930 49.47 µM -1.0930056225549 0.121175180704688 no 3006 0.137195665554281 965 17014836 SGTC_2173 5763948 167 µM -1.09333009085628 0.121106920687448 no 3007 0.137124447857841 954 2867177 SGTC_268 camptothecin 39.6153 µM -1.09472902202207 0.120812930278906 no 3008 0.136817685024656 969 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1329 1447-1697 50.6 µM -1.10006518010085 0.119696131002437 no 3009 0.135651861828555 958 2840515 SGTC_3019 9081971 49.47 µM -1.10903078359043 0.117836159379532 no 3010 0.13370845116672 963 16451803 SGTC_2710 st078562 53.7235 µM -1.11084660837059 0.117461958899428 no 3011 0.133317190262352 972 17250908 SGTC_2062 5245942 200 µM -1.11438091946122 0.116736031576548 no 3012 0.132557902701491 979 1376160 SGTC_1089 terbinafine 2.25 µM -1.11565127776915 0.116475885942267 no 3013 0.132285716797075 941 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3239 9133757 49.47 µM -1.11590794780166 0.116423374691054 no 3014 0.132230769706367 984 17036923 SGTC_2674 ligustilide 100 µM -1.11665512669091 0.116270607503496 no 3015 0.132070905639719 966 5319022 A signalling regulator. SGTC_3159 9100096 49.47 µM -1.11745959649059 0.116106285768316 no 3016 0.131898932839607 958 25236875 SGTC_2274 7947094 46.08 µM -1.11747283548401 0.116103582938768 no 3017 0.131896104011253 957 2971028 SGTC_1563 conessine 56.1 µM -1.11808425906897 0.115978805356272 no 3018 0.131765504298898 962 441082 An anti-amoebic, histamine inhibitor. SGTC_1711 st032263 62.8 µM -1.1182162804686 0.115951875307584 no 3019 0.131737316323521 966 3958979 SGTC_1700 st030840 7.9285 µM -1.12047524565042 0.1154917737838 no 3020 0.131255647805654 959 5499307 SGTC_2458 5808907 16.39 µM -1.12275762495342 0.115028222329165 no 3021 0.130770223414999 962 2731747 SGTC_1256 0570-0116 285 µM -1.12696356306179 0.114177464759379 no 3022 0.129878943420616 964 410638 SGTC_2317 5986382 200 µM -1.12912739804325 0.113741524367024 no 3023 0.129422047510268 988 877883 SGTC_1406 3909-7906 11.9 µM -1.12956138547328 0.113654233435673 no 3024 0.129330544885124 946 X1406 SGTC_2141 5621638 7.665 µM -1.13276994642909 0.113010354607109 no 3025 0.12865543766693 966 2856238 SGTC_3319 9138450 16.7555 µM -1.13292339551007 0.112979626534818 no 3026 0.12862321212167 932 2029690 SGTC_1352 1496-0991 99 µM -1.13296771183683 0.112970753330954 no 3027 0.128613906377967 978 3000039 SGTC_1547 harmine 94.2 µM -1.13395764568548 0.112772674194296 no 3028 0.128406157345255 950 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2377 9073351 62.6 µM -1.13621818833625 0.112321284712984 no 3029 0.127932630118074 979 7337946 YHR072W ERG7 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.13675129056377 0.112215022235209 no 3030 0.127821135547981 959 2333 A French combination drug. SGTC_538 2922-0838 53.3 µM -1.13783285747047 0.111999655903089 no 3031 0.127595140981132 982 777039 SGTC_504 lovastatin 124 µM -1.13837933300615 0.11189095175657 no 3032 0.127481060032787 973 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_386 1509-0011 3.07 µM -1.13895500342088 0.111776521830507 no 3033 0.127360961163872 962 3107280 SGTC_3178 9107506 49.47 µM -1.14114103303572 0.111342752335841 no 3034 0.126905619065642 954 8897194 SGTC_721 1187-1332 279 µM -1.14177249787076 0.111217676628339 no 3035 0.126774298427304 976 25730 SGTC_2033 5192550 145 µM -1.14203446589342 0.111165817547172 no 3036 0.126719846832836 939 182073 SGTC_755 1995-0008 37.3 µM -1.14207238018936 0.111158313483392 no 3037 0.126711967472707 945 689533 SGTC_680 0417-1641 114 µM -1.14411651456426 0.110754271632089 no 3038 0.126287659835036 964 2835990 SGTC_2911 7942208 15.64 µM -1.14528095826586 0.110524579713141 no 3039 0.126046395627854 931 1243384 SGTC_3051 9093778 49.47 µM -1.14576724565399 0.110428758419257 no 3040 0.125945735626128 996 17217378 SGTC_1617 st002906 78 µM -1.14636629935033 0.110310798803288 no 3041 0.125821810422708 972 5150859 SGTC_1097 itavastatin 7.23 µM -1.14855025110811 0.109881522287917 no 3042 0.125370740426038 951 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1675 st018485 24.5 µM -1.15030298246586 0.109537874432371 no 3043 0.125009551428489 975 3323024 SGTC_2841 9004761 38.96 µM -1.15218444673682 0.109169846281629 no 3044 0.124622643756933 955 2991039 SGTC_1433 4060-0023 7.6 µM -1.15453503667543 0.108711303270845 no 3045 0.124140441421381 965 3840627 SGTC_488 nitrendipine 139 µM -1.15540006933003 0.108542905546705 no 3046 0.123963316773478 999 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1470 k295-0292 231 µM -1.15998987908278 0.107652536531751 no 3047 0.123026463392607 988 5045612 SGTC_115 0527-0192 112.043 µM -1.16012246904778 0.10762689407598 no 3048 0.122999473628157 976 4233931 SGTC_3275 9138069 49.47 µM -1.1602870695922 0.107595067004519 no 3049 0.122965973625786 974 17617007 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.1626747057522 0.107134157467393 no 3050 0.122480753951733 975 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2365 9042475 200 µM -1.16624454015141 0.106447694839788 no 3051 0.121757794573194 955 6464479 SGTC_3294 9122953 26.2835 µM -1.16677256762673 0.106346427824624 no 3052 0.121651114041129 973 16459826 SGTC_1838 st055369 84.5 µM -1.16677897382109 0.106345199648843 no 3053 0.121649820163003 959 676036 SGTC_1227 3909-8010 46.6 µM -1.16748880165486 0.106209177090113 no 3054 0.121506514024386 965 15982272 SGTC_2280 7785178 200 µM -1.16851095606453 0.106013525007947 no 3055 0.121300361259871 957 2954328 SGTC_2857 9024691 58.44 µM -1.17838499133154 0.104136918595714 no 3056 0.11932157919587 979 16478292 SGTC_2146 5545642 200 µM -1.18276168357123 0.103312855567876 no 3057 0.118451805028544 971 825326 SGTC_554 4483-2211 187 µM -1.18396157432923 0.103087763933735 no 3058 0.118214136987387 986 747107 SGTC_2762 leflunomide 42.06 µM -1.18407980808193 0.10306560335044 no 3059 0.118190736131722 983 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2870 9038528 12.99 µM -1.18700939872171 0.102517613982116 no 3060 0.11761195662517 985 6463316 SGTC_127 0180-0333 59.125 µM -1.19061364499205 0.101846338155497 no 3061 0.116902646231063 908 771601 SGTC_532 1548-0774 215 µM -1.19524391879146 0.100988671702294 no 3062 0.115995871922119 994 5932993 SGTC_1308 1187-1617 41.4 µM -1.199182514575 0.100263278924921 no 3063 0.115228492361843 973 2882570 SGTC_1419 3993-2473 62.6 µM -1.20050665211319 0.100020261523885 no 3064 0.114971315352859 983 704026 SGTC_1185 1319-0113 81.3 µM -1.2039545991009 0.0993894825977999 no 3065 0.114303563447292 986 4672763 SGTC_1154 4088-0362 150 µM -1.20739218297656 0.0987634993547097 no 3066 0.113640572279112 978 6618304 SGTC_1000 4048-0884 8.67 µM -1.20978062220349 0.0983302670862074 no 3067 0.113181541888429 984 13040088 SGTC_1633 st005664 67.9 µM -1.21011389462914 0.0982699265618663 no 3068 0.113117596108516 999 2063822 SGTC_380 3970-0968 6 µM -1.2107132149253 0.0981614850782647 no 3069 0.11300266795739 976 2891601 SGTC_667 1498-1044 59 µM -1.21099940597931 0.0981097323822603 no 3070 0.112947816180868 990 6739982 SGTC_2051 5263410 176 µM -1.21233331793986 0.0978687812156312 no 3071 0.11269240747177 976 227584 SGTC_616 4092-0450 108 µM -1.21758624449284 0.0969241358262874 no 3072 0.111690622140785 997 787165 SGTC_3316 9136639 10.545 µM -1.22064633547411 0.0963769277746328 no 3073 0.111109977277473 958 4903665 SGTC_2073 5212005 126 µM -1.22159361298347 0.096207995855841 no 3074 0.110930672579826 975 691789 SGTC_521 r062-0005 13.8 µM -1.22306576311082 0.0959458933744331 no 3075 0.110652429293671 979 2832033 SGTC_510 ag-490 170 µM -1.2282619660977 0.0950249563597806 no 3076 0.109674321854153 998 5328779 SGTC_371 0195-0006 7.36 µM -1.23089082097074 0.0945615252458508 no 3077 0.109181850555887 949 3928593 SGTC_793 0488-0545 106 µM -1.23256055382499 0.094268040700326 no 3078 0.108869880762371 983 292548 SGTC_1632 st005650 90 µM -1.23298622633228 0.0941933289471762 no 3079 0.108790451515933 970 2759605 SGTC_2715 st079500 56.4 µM -1.23804357400069 0.093309030369825 no 3080 0.107849952180375 979 28246688 SGTC_744 1594-0068 283 µM -1.23865498367315 0.0932025397742004 no 3081 0.107736648207057 996 668392 SGTC_2170 morpholine 200 µM -1.24457580984975 0.092175938500382 no 3082 0.106643858427584 989 121171 Reacts with secondary amines. SGTC_1094 duloxetine 25.4 µM -1.24590396920159 0.091946805195543 no 3083 0.106399826362063 985 60834 A selective serotonin reuptake inhibitor. SGTC_543 3844-1095 191 µM -1.24716688255216 0.0917293195912016 no 3084 0.106168156642779 984 4230703 SGTC_963 1269-2853 151 µM -1.24766713183875 0.0916432773995039 no 3085 0.106076491386299 992 3668223 SGTC_2414 st077232 92.9 µM -1.24858015378602 0.0914863930736388 no 3086 0.105909337461844 967 729801 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.24987188467532 0.0912647754343045 no 3087 0.105673175687467 1014 279621 SGTC_2265 7929201 200 µM -1.25010183987825 0.0912253646165349 no 3088 0.105631173890169 976 1265108 SGTC_1072 oxiconazole 14.9 nM -1.25602267167454 0.0902149651200979 no 3089 0.10455387515553 970 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1550 gossypolone 36.6 µM -1.25992246965336 0.0895540139218243 no 3090 0.103848666043166 990 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1477 0139-0234 16 µM -1.26392806103766 0.0888788883660859 no 3091 0.103127924440725 996 620880 SGTC_2356 9061756 188.97 µM -1.2648262454543 0.0887280246206281 no 3092 0.102966810454241 973 20104043 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.26623213045407 0.0884922678243053 no 3093 0.102714993681665 985 688761 SGTC_2534 helenine 20.12 µM -1.26634178735425 0.0884738987905873 no 3094 0.102695371188123 975 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_905 2-aminofluorene 215 µM -1.26948955794647 0.0879478145834426 no 3095 0.102133256233866 990 1539 An established DNA mutagen. YPR165W RHO1 SGTC_411 enrofloxacin 100 µM -1.27320011707078 0.0873306718755035 no 3096 0.101473519528581 977 71188 A bacterial gyrase inhibitor. SGTC_3175 9106517 49.47 µM -1.28194800411403 0.0858885214554701 no 3097 0.0999304433650181 995 41468073 SGTC_1922 5578187 25 µM -1.28505029057571 0.0853813922015767 no 3098 0.0993873553578239 932 1350412 SGTC_1349 flufenamic acid 69 µM -1.28652508882211 0.0851410956907424 no 3099 0.0991299343230975 986 3371 A non-steroidal anti-inflammatory. SGTC_2780 5215298 71.43 µM -1.28956274437482 0.0846477522449618 no 3100 0.0986012590188858 995 2834131 SGTC_1696 st025591 34.7925 µM -1.29105488098803 0.0844062020792272 no 3101 0.0983423239184543 970 2787147 SGTC_3333 9141820 12.094 µM -1.29204631763098 0.0842459924845669 no 3102 0.0981705524254333 976 1939433 SGTC_1156 4092-0367 4.88 µM -1.29207283159516 0.0842417111391451 no 3103 0.0981659617643563 978 1357585 SGTC_536 3852-0578 10.6 µM -1.29283552551663 0.0841186249510827 no 3104 0.0980339752992057 1007 2869208 SGTC_1849 st056239 19.2 µM -1.29441363054529 0.0838643736455969 no 3105 0.0977612924706761 978 5393181 SGTC_3212 9128307 49.47 µM -1.29478600998339 0.0838044631820449 no 3106 0.0976970297010724 992 27243542 SGTC_1007 4101-0031 70 µM -1.29568834842037 0.0836594233173647 no 3107 0.0975414385918287 1014 1146276 SGTC_2040 5100729 123 µM -1.29789833218618 0.083304992143722 no 3108 0.0971611366311668 1008 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_643 k048-0106 28.4 µM -1.29814779880624 0.0832650543781475 no 3109 0.0971182759600538 1003 6763920 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.30018725931185 0.0829390915225744 no 3110 0.0967683981268546 991 6857784 SGTC_2120 5538279 151.968 µM -1.30097756875572 0.082813036343924 no 3111 0.0966330664343093 1004 2058197 SGTC_3337 9144342 33.5465 µM -1.30119359076847 0.0827786057068084 no 3112 0.0965960992747653 987 17682949 SGTC_272 doxorubicin 8.13 µM -1.30193182823235 0.0826610231375173 no 3113 0.0964698454606151 998 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1465 k213-0056 144 µM -1.30205849136797 0.0826408615412981 no 3114 0.096448195646767 944 24048857 YMR208W ERG12 SGTC_3091 9116372 49.47 µM -1.30283527653302 0.0825172977547359 no 3115 0.0963155022259386 1004 17169793 SGTC_917 harmaline 728.087 nM -1.30752333247637 0.0817745162372499 no 3116 0.095517517970638 968 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1197 1601-0112 267 µM -1.30786588422169 0.0817204401277851 no 3117 0.0954594013551735 1001 7350313 SGTC_2386 9075165 157.42 µM -1.30885975198866 0.0815636981451624 no 3118 0.0952909311296955 988 16452277 SGTC_472 calcifediol 10 µM -1.309254179044 0.0815015562854782 no 3119 0.0952241326299738 1008 5283731 A vitamin D metabolite. SGTC_1439 4092-1168 46 µM -1.31200492079832 0.0810691701728622 no 3120 0.0947592371213711 1008 2886240 SGTC_3198 9112019 49.47 µM -1.31348184904218 0.0808377288669477 no 3121 0.0945103166049843 1025 45595555 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.31405809930045 0.0807475632684769 no 3122 0.0944133266179415 999 364106 SGTC_120 rhodamine 6G 52.259 µM -1.3141912414206 0.0807267413897288 no 3123 0.094390927607683 1004 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2135 5326629 150.42 µM -1.31511520773839 0.0805823554919421 no 3124 0.0942355931535894 994 5020077 SGTC_1442 4112-3290 3 µM -1.31708863752548 0.0802746259077625 no 3125 0.093904457617279 1015 704353 SGTC_1489 4065-0444 182 µM -1.31743785416321 0.080220262921739 no 3126 0.0938459496633728 962 2877968 SGTC_1090 efavirenz 20.7 µM -1.32455495020042 0.0791183890349823 no 3127 0.092659403059926 982 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_78 0336-0123 156.75 µM -1.32624383392977 0.078858605261957 no 3128 0.0923794721403359 986 6765896 SGTC_2892 9047358 58.44 µM -1.32783843724788 0.0786139172909466 no 3129 0.0921157429610543 1002 6466771 SGTC_1898 st060199 18.6 µM -1.32784894471992 0.0786123068556837 no 3130 0.0921140069956976 978 688866 SGTC_1327 1436-0082 2.18 µM -1.32988434186709 0.0783008215551789 no 3131 0.0917781906036643 1006 15992205 SGTC_1724 st037281 8.293 µM -1.33067880346053 0.078179496064128 no 3132 0.0916473602334804 964 574124 YDL195W SEC31 SGTC_409 arachidonic acid 100 µM -1.3317208978141 0.0780205698098378 no 3133 0.091475959763319 993 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_369 0957-0393 4.5 µM -1.33203476861507 0.0779727505085396 no 3134 0.091424381845686 995 6997992 SGTC_849 0386-0493 241 µM -1.33323098675696 0.0777907064110016 no 3135 0.0912280067408414 1007 726119 SGTC_1919 st067113 52.3 µM -1.33470321435206 0.077567101409138 no 3136 0.0909867505676914 998 1268243 SGTC_1896 st058441 89 µM -1.33737070660782 0.0771632008101302 no 3137 0.0905508307161832 981 688759 SGTC_1455 4262-0120 131 µM -1.34138846444251 0.0765578675261622 no 3138 0.0898971804565702 987 1529587 SGTC_396 dithiazanine 1.25 µM -1.3455132346065 0.0759401759198937 no 3139 0.0892297751454474 988 10578 An antihelmenthic. SGTC_1165 k072-0275 30.3 µM -1.34565853237087 0.0759184867205812 no 3140 0.0892063327543976 997 6153523 YGL055W OLE1 SGTC_1253 0550-0034 176 µM -1.34663853118443 0.0757723214220927 no 3141 0.08904833909126 995 5969915 SGTC_1880 MG-132 525 µM -1.34703388740129 0.0757134153728271 no 3142 0.0889846594595469 979 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1512 0259-0544 12.2 µM -1.3473283764242 0.0756695606924193 no 3143 0.0889372484392496 978 18476 SGTC_1452 4194-0072 190 µM -1.34860436593154 0.075479766589809 no 3144 0.0887320387985642 1002 1343545 SGTC_3192 9110362 49.47 µM -1.35566581359717 0.0744359810533103 no 3145 0.0876027606529085 1024 16649480 SGTC_1481 3346-2004 36 µM -1.3610548327319 0.0736468466127091 no 3146 0.0867481809484648 1018 2770522 SGTC_1943 st076331 65.2 µM -1.37097643403563 0.0722107380674856 no 3147 0.0851911512085823 1017 24208415 SGTC_2564 betulinic acid 100 µM -1.37181086711778 0.0720909428657272 no 3148 0.085061161696532 1017 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2877 9040724 71.43 µM -1.37649933381961 0.0714206751681209 no 3149 0.0843335467133352 1011 6463895 SGTC_2039 Aminomethylbenzodioxan 200 µM -1.37989525542084 0.0709381852444658 no 3150 0.083809448828983 1018 15053 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -1.38002005386886 0.0709205017912558 no 3151 0.0837902351989784 1016 4174840 SGTC_1574 spiramycin 23.7 µM -1.38012258528572 0.0709059760234383 no 3152 0.083774452216501 998 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2537 larixol 68.93 µM -1.38015145730587 0.070901886096778 no 3153 0.0837700082588899 998 6708759 SGTC_2072 5231554 129 µM -1.38184980939926 0.0706616211852385 no 3154 0.0835089107579862 999 789545 SGTC_1425 4048-4433 7.33 µM -1.38294585498633 0.0705068967526136 no 3155 0.0833407343140384 1043 23734946 SGTC_3099 9120367 49.47 µM -1.38322551543369 0.0704674599239376 no 3156 0.0832978642127751 1016 24824940 SGTC_379 3970-0972 5.9 µM -1.38352468331227 0.0704252909948271 no 3157 0.0832520221064863 1017 2898042 YBL034C STU1 SGTC_624 k048-0052 28 µM -1.38442488101277 0.0702985214829953 no 3158 0.0831141973765097 1019 6835531 SGTC_1963 st076565 50.3 µM -1.40040254701805 0.0680775688578149 no 3159 0.0806964038711138 1026 4914280 SGTC_2800 7887935 81.82 µM -1.40063049670137 0.0680462795827421 no 3160 0.0806622982189785 1035 2961002 SGTC_2468 5987765 72.9 µM -1.40524044073769 0.0674158804036568 no 3161 0.0799748961627412 1014 26772094 SGTC_2612 dictamnine 15.46 µM -1.40601733342808 0.0673100880035968 no 3162 0.0798594888823426 973 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.40662875593516 0.0672269185828211 no 3163 0.0797687507718989 1039 5357218 A potent inhibitor of glutathione S-transferases. SGTC_806 3966-4455 5.86 µM -1.41759886844056 0.0657481615749709 no 3164 0.0781539553547271 1004 714982 SGTC_3000 9075062 71.4286 µM -1.42301431387646 0.0650275239764494 no 3165 0.0773660029254515 970 17057871 SGTC_2166 5933061 31.504 µM -1.4272585777893 0.0644670336304693 no 3166 0.0767526877361999 1015 2877375 SGTC_1363 1636-0063 10.4 µM -1.43013498120221 0.064089319426147 no 3167 0.0763391409893917 1006 6072185 SGTC_315 k915-0449 187 µM -1.43031628537978 0.0640655692759139 no 3168 0.0763131314089952 1005 20970215 YNL149C PGA2 SGTC_2889 9059656 51.95 µM -1.43055192307757 0.064034711870153 no 3169 0.0762793373150272 1022 3949838 SGTC_289 k017-0060 526 µM -1.4328301096108 0.063736972712861 no 3170 0.0759531971849187 1025 5512909 SGTC_596 1155-0152 116 µM -1.43660550190195 0.0632459343295027 no 3171 0.0754150596983381 1010 280313 SGTC_1290 0986-0249 10.2 µM -1.43901111821134 0.0629345925611347 no 3172 0.0750736863411907 1015 53329 SGTC_1912 st060209 90.8 µM -1.44015934774172 0.062786406981901 no 3173 0.0749111607943971 1020 688787 SGTC_3301 9125354 19.7965 µM -1.44106950663551 0.0626691390672855 no 3174 0.0747825236337854 997 41905162 SGTC_1337 1486-1011 40.3 µM -1.44664620357298 0.061954342339065 no 3175 0.0739980193341134 1013 X1337 SGTC_1484 3473-2379 286 µM -1.44769719822066 0.0618203457417082 no 3176 0.073850876933507 1057 671917 SGTC_1784 st039334 36.3 µM -1.45242263758515 0.0612206689630038 no 3177 0.0731920628123268 1008 3496984 SGTC_1555 citronellol 128 µM -1.4536490577425 0.0610657767806538 no 3178 0.0730218142138643 1020 8842 A terpine precursor. SGTC_1930 st074634 34.3 µM -1.45439423465885 0.0609718134858565 no 3179 0.0729185187275183 1004 684253 YOR116C RPO31 SGTC_1993 st073995 70.8 µM -1.45451425413216 0.0609566901702638 no 3180 0.0729018922426125 1011 3098394 SGTC_3008 9078912 71.4286 µM -1.45809253535529 0.0605071467202299 no 3181 0.0724075193208122 1028 16648731 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.46257747113234 0.0599473670991087 no 3182 0.0717915157809411 1023 66535 A nucleotide analog. SGTC_2152 5568786 200 µM -1.46335183356371 0.0598511282837764 no 3183 0.0716855656278291 1024 5399883 SGTC_399 oxolinic acid 75 µM -1.46673265645563 0.0594323719676686 no 3184 0.0712243977942496 1021 4628 A DNA gyrase inhibitor. SGTC_1269 0831-0796 3.05 µM -1.46717414063117 0.0593778587055346 no 3185 0.0711643447936096 979 927758 SGTC_1075 aripiprazole 15.2 µM -1.4695370294095 0.0590867617192582 no 3186 0.0708435929081406 1032 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2904 7225135 42.03 µM -1.46955140319166 0.0590849943673044 no 3187 0.0708416451340489 1047 4446116 SGTC_2529 gangaleoidin 93.61 µM -1.47478389643034 0.0584443750014247 no 3188 0.0701353260004307 1038 4565183 SGTC_1857 st056007 79.3 µM -1.47563439559815 0.0583407648215695 no 3189 0.0700210331608088 1012 619834 SGTC_15 0266-0086 27.098 µM -1.47706708938757 0.0581665563381548 no 3190 0.0698288271960336 1042 1712902 YIL048W NEO1 SGTC_2900 5328528 85.29 µM -1.47771331706569 0.0580881121185615 no 3191 0.0697422641966265 1011 795359 SGTC_1605 st000082 49.1 µM -1.47980376917068 0.0578349258311929 no 3192 0.0694628112561034 991 1114022 SGTC_303 1348-1668 34.2 µM -1.48011011131628 0.0577978960226243 no 3193 0.0694219317935387 1033 5380509 SGTC_2694 st077685 81.9 µM -1.4942908631997 0.0561040778190213 no 3194 0.0675498061011657 1016 2838096 SGTC_302 1094-0063 18.9 µM -1.4988972442365 0.0555623720420645 no 3195 0.0669501457070028 1017 5440289 SGTC_1065 prochlorperazine maleate 2.48 µM -1.50411524637328 0.0549537367895703 no 3196 0.0662758476306861 1035 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1956 st077085 54 µM -1.50514034156631 0.05483478970929 no 3197 0.0661439996125553 1026 24208685 SGTC_1870 st057514 26.5 µM -1.51205648277411 0.0540375840724932 no 3198 0.0652597470826163 1020 5393161 SGTC_1393 3470-5649 58.2 µM -1.51507416034339 0.0536926315545747 no 3199 0.0648768122736898 1017 4108395 SGTC_1078 idebenone 36.1 µM -1.5195530744102 0.0531838622967562 no 3200 0.0643116696397307 1032 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_145 3737-0113 38.366 µM -1.51974421513719 0.0531622355461428 no 3201 0.064287637179784 1016 6849351 SGTC_2869 9037858 32.47 µM -1.52038080588359 0.0530902583187225 no 3202 0.0642076478338679 1028 27187042 SGTC_771 0250-0039 27.3 µM -1.52064374745162 0.0530605509372006 no 3203 0.0641746311002744 1029 3005115 SGTC_2695 st077686 51.995 µM -1.5213829984431 0.0529771002985727 no 3204 0.0640818764204738 1024 2876092 SGTC_1659 st012954 42.1 µM -1.52249044676267 0.0528522803641745 no 3205 0.0639431186607434 1021 24207262 SGTC_256 clotrimazole 625 nM -1.52904324219527 0.0521184854895471 no 3206 0.0631268621703648 1004 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_924 2046-0044 21.3 µM -1.53674573668159 0.0512663174236705 no 3207 0.0621777931171139 1018 3623589 SGTC_2165 5727197 32.143 µM -1.53686538374451 0.0512531681928124 no 3208 0.0621631389891291 1026 1361712 SGTC_1222 0366-0074 1.18 µM -1.55394638834474 0.0494033331044111 no 3209 0.0600986026440834 1039 286520 SGTC_157 1348-1695 65.819 µM -1.55708197069908 0.0490696187025831 no 3210 0.0597255125006733 999 5380510 SGTC_420 mitomycin C 81.9 mM -1.55856110921534 0.0489128229274555 no 3211 0.0595501469361314 1008 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_244 nsc-207895 1.295 µM -1.56343069253124 0.0483994504916497 no 3212 0.0589756628272996 1009 42640 SGTC_1559 coumarin 343 70.1 µM -1.57050989527934 0.0476608265777695 no 3213 0.0581482670677404 1024 108770 A hepatotoxic, DNA x-linker. SGTC_2026 5148700 152 µM -1.58426138363339 0.0462518504902763 no 3214 0.0565671248213729 1044 79838 SGTC_1062 mesoridazine 14.2 µM -1.58774955456118 0.0458998229987763 no 3215 0.0561714912929818 1026 4078 A neuroleptic. SGTC_2792 7535235 81.82 µM -1.59196619176187 0.0454771562007522 no 3216 0.0556961506036752 1022 1281891 SGTC_2974 9094440 9.66 µM -1.59483766428665 0.0451911214746269 no 3217 0.0553742710574869 1018 25236134 SGTC_719 2810-4230 27.3 µM -1.59776338592278 0.0449011734547782 no 3218 0.0550478230225291 1055 721079 SGTC_174 3553-0389 74.3 µM -1.60117352472574 0.0445651103237733 no 3219 0.0546692455154619 1043 738071 SGTC_741 4582-0002 126 µM -1.60584900365214 0.0441076467391135 no 3220 0.0541535453141722 1031 2912688 SGTC_848 0368-0089 85.6 µM -1.60695301744087 0.0440001809721883 no 3221 0.0540323374254156 1025 762535 SGTC_2404 5161160 200 µM -1.62826608113883 0.0419666236868028 no 3222 0.0517342391571406 1012 2831543 SGTC_3254 9136651 49.47 µM -1.63000181899718 0.0418044174970387 no 3223 0.0515505562681555 1055 16454030 SGTC_885 0865-0106 16.8 µM -1.64630100908779 0.0403058856596061 no 3224 0.0498509009214709 1038 2793380 SGTC_203 k066-0004 30.888 µM -1.64663739500107 0.0402754242807028 no 3225 0.0498162996610227 1067 6795412 SGTC_1662 st014054 52 µM -1.65343690913536 0.0396636939854718 no 3226 0.0491209881785406 1053 2838777 SGTC_2569 tetrandrine 100 µM -1.6574256547906 0.0393083696332563 no 3227 0.0487167240918785 1024 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1931 st074438 57.1 µM -1.65899177919743 0.0391695666253608 no 3228 0.0485587244309711 1048 2787313 SGTC_1325 1431-0015 227 µM -1.65920892967391 0.0391503524696482 no 3229 0.0485368494178866 1041 1103340 SGTC_3249 9135183 49.47 µM -1.66366666384475 0.0387576106025982 no 3230 0.0480895308455471 994 4902779 SGTC_1013 4112-3890 241 µM -1.67675415378971 0.037623068055209 no 3231 0.0467952830912738 1032 705171 SGTC_2394 5221648 200 µM -1.67796688642164 0.0375193244242421 no 3232 0.0466767817965421 1050 788586 SGTC_1806 st050005 60.3 µM -1.68417976914424 0.0369914991818194 no 3233 0.0460734659143252 1044 5194765 SGTC_3216 9129716 49.47 µM -1.69266673757379 0.0362803003817645 no 3234 0.045259460009425 1024 8056934 SGTC_499 genistein 192 µM -1.69276378578245 0.0362722330376385 no 3235 0.0452502192244095 1062 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3191 9110352 49.47 µM -1.70007267774374 0.0356688723721924 no 3236 0.0445586279060434 1024 17122424 SGTC_3156 9099931 49.47 µM -1.7025255923723 0.0354682334309091 no 3237 0.0443284425663828 1056 18111053 SGTC_189 3970-0742 2.116 µM -1.71130885722306 0.0347573723819512 no 3238 0.0435120560784755 1035 2891807 SGTC_421 streptovitacin 30 mM -1.72397962999257 0.0337525317048865 no 3239 0.0423557602737526 1050 91467 include heat shock SGTC_149 3970-0822 46.1 µM -1.72745404968464 0.0334812114477519 no 3240 0.0420430753953732 1029 3114250 YBL034C STU1 SGTC_2111 5486399 200 µM -1.73323573845801 0.0330336962116584 no 3241 0.0415268886486209 1033 689674 SGTC_531 3788-1495 174 µM -1.73381321053137 0.0329892706297805 no 3242 0.0414756154574551 1032 2896655 SGTC_1387 3342-1166 1.8 µM -1.73647376867426 0.0327852264074581 no 3243 0.0412400492986758 1033 3418228 SGTC_2090 5301565 104.445 µM -1.73974370520123 0.0325358739717279 no 3244 0.0409520156729012 1048 2056344 SGTC_1357 1503-1303 39.5 µM -1.74133097653401 0.0324154000896136 no 3245 0.040812789710723 1042 292895 SGTC_847 0342-0274 5.54 µM -1.74394067844512 0.0322181239107279 no 3246 0.0405847172212649 1043 18097 SGTC_2592 piperlongumine 83.33 µM -1.74742488055845 0.0319562870592253 no 3247 0.0402818323812702 1048 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3220 9131269 49.47 µM -1.74891114813365 0.0318451304109572 no 3248 0.0401531896257012 1044 17722206 SGTC_877 0771-0151 33.1 µM -1.75384133438822 0.0314786908021031 no 3249 0.0397288491093741 1057 6166523 SGTC_1785 bathophenanthroline 24 µM -1.75633424861189 0.0312947341997628 no 3250 0.0395156763095467 992 72812 An iron chelator. SGTC_200 k038-0079 37.545 µM -1.75795640491932 0.0311755105213632 no 3251 0.0393774636592754 1066 3436683 SGTC_192 3455-0609 60.9 µM -1.75882661235347 0.0311117078507253 no 3252 0.0393034815870029 1053 3769639 SGTC_47 0149-0135 24.25 µM -1.76875990312446 0.0303910347549694 no 3253 0.0384669754002014 1053 5239155 SGTC_2197 6588183 93.1375 µM -1.77077237271775 0.0302467254971956 no 3254 0.0382992809398202 1045 884136 SGTC_578 3460-0051 92 µM -1.78160146039913 0.0294799162826953 no 3255 0.0374071230611616 1058 2876744 SGTC_1763 st044482 94.5 µM -1.79959612750379 0.0282414345257663 no 3256 0.0359622165023935 1055 88505 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.80381925135507 0.0279571395818367 no 3257 0.0356298234308056 1040 23847180 SGTC_569 4130-2812 160 µM -1.80541872317321 0.0278500895140601 no 3258 0.0355045917331461 1060 743552 SGTC_1190 1486-1332 13 µM -1.80834688276909 0.0276549973367998 no 3259 0.0352762647074638 1045 4150046 SGTC_2134 5324836 1.464 µM -1.81045405038976 0.0275153106028727 no 3260 0.0351127019379465 1058 699272 SGTC_1925 st057770 10.1 µM -1.81092075585348 0.0274844518238371 no 3261 0.0350765595842005 1044 5989122 SGTC_2258 7960471 200 µM -1.81990504701116 0.0268960084190286 no 3262 0.0343867331020596 1067 2974708 SGTC_74 000s-0487 160.283 µM -1.82698119789344 0.026439979837791 no 3263 0.0338512982174516 1034 677548 SGTC_1285 0929-0069 65.5 µM -1.83043888017966 0.0262195074192125 no 3264 0.0335921691635459 1063 1206237 SGTC_1122 capsaicin 818.572 nM -1.83376012408922 0.0260091841155537 no 3265 0.0333448046726983 1057 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1643 st009866 20.2 µM -1.83680803498614 0.0258174136986532 no 3266 0.0331191196685102 1038 3156273 YOR207C RET1 SGTC_1339 1486-1321 22.7 µM -1.84348598595393 0.0254013799033961 no 3267 0.032629042988545 1052 3469382 SGTC_1965 Pectolinarigenin 58.4 µM -1.84418684954408 0.025358043811785 no 3268 0.0325779570939855 1071 5320438 An anti-inflammatory. SGTC_1527 coumarin 137 µM -1.8442116667136 0.0253565104422012 no 3269 0.0325761493823639 1059 323 A hepatotoxic, DNA x-linker. SGTC_1299 1079-1439 3.74 µM -1.85431324052403 0.0247387858493547 no 3270 0.0318471794710221 1059 323161 SGTC_1786 berberine 21.6 µM -1.87897273880797 0.0232836664946738 no 3271 0.0301241078283325 1009 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2498 4'-Methoxychalcone 54.63 µM -1.88055503596246 0.0231928100111549 no 3272 0.0300162365595658 1053 641818 YHR062C RPP1 SGTC_1842 st055362 61.2 µM -1.88501864554168 0.0229381139603628 no 3273 0.0297136602598958 1062 676032 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.89511815780958 0.0223705162388206 no 3274 0.0290383747837446 1064 16486 A toxic proline analog. SGTC_796 1234-0020 70.7 µM -1.90295127073766 0.0219384902482605 no 3275 0.028523451986455 1044 46495034 SGTC_1819 st053448 58.6 µM -1.90572783597363 0.0217870528982984 no 3276 0.0283427629253737 1077 2857616 SGTC_342 k048-0088 23.3 µM -1.90708391492819 0.0217134121677972 no 3277 0.0282548609145626 1056 6820570 SGTC_2775 cyproheptadine 69.59 µM -1.91287989526797 0.0214010320162917 no 3278 0.0278817149586572 1054 2913 A selective serotonin reuptake inhibitor. SGTC_1777 st045864 34.765 µM -1.91399517182419 0.0213413610282269 no 3279 0.027810386335551 1078 4691462 SGTC_331 k048-0133 24.5 µM -1.91805830507817 0.0211251584639052 no 3280 0.0275518092726005 1064 6813582 SGTC_1123 mangostin 811.285 nM -1.92130962545391 0.0209534904170219 no 3281 0.027346342188062 1035 5281650 An antioxidant. SGTC_2409 alverine citrate 63.97 µM -1.94167160974422 0.019905026557168 no 3282 0.0260884338622143 1044 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3201 9113999 49.47 µM -1.94687062715732 0.019644571227511 no 3283 0.0257751234489933 1052 16649224 SGTC_346 4513-0042 7.16 µM -1.94887119001485 0.0195451228333135 no 3284 0.0256554046988361 1042 2827372 SGTC_3229 9132204 49.47 µM -1.9636364123698 0.0188242814899898 no 3285 0.024786135782799 1079 17682924 SGTC_714 4296-0578 26.1 µM -1.96636400044178 0.0186936256898385 no 3286 0.0246282893753125 1073 1589775 SGTC_1015 4130-4525 82 µM -1.98384459125249 0.0178744705771998 no 3287 0.0236365837045748 1061 1363237 SGTC_1594 piperine 70.1 µM -1.98839652253461 0.0176662570676037 no 3288 0.0233839265485317 1066 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1474 0330-0125 5.35 µM -1.99876894079179 0.0171995235480997 no 3289 0.0228166798987162 1080 X1474 SGTC_860 0443-0016 25.1 µM -2.00139893199062 0.0170828686609909 no 3290 0.0226747078449302 1063 5337942 SGTC_1526 st051518 75 µM -2.00961364175646 0.0167228452896078 no 3291 0.0222360481497417 1050 673993 SGTC_1278 0874-0585 172 µM -2.01047395058138 0.0166855190659518 no 3292 0.0221905252744708 1074 766306 SGTC_1557 sumaresinolic acid 42.3 µM -2.01443593511716 0.0165145391213393 no 3293 0.0219818923559002 1059 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3066 9117245 49.47 µM -2.04688250745775 0.0151698948407524 no 3294 0.02033481100212 1056 17176980 SGTC_3241 9133421 49.47 µM -2.06112482224711 0.0146100439062821 no 3295 0.0196455666389185 1085 17018221 SGTC_942 3253-1115 227 µM -2.07909295789578 0.0139291737632482 no 3296 0.0188044036213517 1062 46497897 SGTC_3258 9138477 49.47 µM -2.08314313018417 0.013779534702878 no 3297 0.0186190895096292 1084 4970355 SGTC_2942 9052777 62.25 µM -2.09157184311109 0.0134725646850471 no 3298 0.0182384167424883 1073 6469503 SGTC_177 1327-0068 8.361 µM -2.10359253659364 0.0130449989648329 no 3299 0.0177070027762488 1059 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_6 0844-0013 19.835 µM -2.10924829168877 0.0128479199125509 no 3300 0.0174615777585364 1088 1584900 SGTC_1740 st038286 13.222 µM -2.1137872195936 0.0126916253264108 no 3301 0.0172667225157403 1058 716786 SGTC_3028 9087778 49.47 µM -2.11451779613796 0.0126666228119781 no 3302 0.0172355332140984 1075 17217395 SGTC_172 1112-0046 2.638 µM -2.11497050649536 0.0126511511094457 no 3303 0.0172162305597583 1075 2802135 YIL048W NEO1 SGTC_1534 6-azauridine 81.6 µM -2.13332085032648 0.0120376320455185 no 3304 0.0164492074737563 1062 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_991 3996-0057 64.7 µM -2.13720000556299 0.011911292779811 no 3305 0.0162908637974512 1072 715343 SGTC_572 0960-0087 17.7 µM -2.15135370752709 0.0114600290221485 no 3306 0.0157241460550118 1073 6796365 SGTC_1546 5-methoxyflavanone 78.7 µM -2.1664317325214 0.0109957047255214 no 3307 0.0151391056458145 1086 147795 SGTC_300 r073-0011 5.04 µM -2.17827530931396 0.0106425464074019 no 3308 0.0146927731189513 1084 2735780 SGTC_1839 st053978 48 µM -2.19242819136413 0.0102335189549566 no 3309 0.0141743014409673 1082 3788398 SGTC_1684 st024538 14.6195 µM -2.19621219623894 0.0101265090863721 no 3310 0.0140383794120054 1081 6732859 SGTC_307 1501-1223 22.3 µM -2.198324429878 0.010067201735239 no 3311 0.0139629973439988 1077 2830329 SGTC_999 SEC7.066 22.7 µM -2.20182258247227 0.00996964708528991 no 3312 0.0138389216286983 1082 740511 YDR170C SEC7 SGTC_2750 bromebric acid 70.15 µM -2.20556609275824 0.00986616508876366 no 3313 0.013707197687111 1073 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2419 paclitaxel 166.5 µM -2.21832181748854 0.00952056870472775 no 3314 0.0132664488093823 1062 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_574 1315-0397 40 µM -2.2341235095487 0.00910715880094371 no 3315 0.012737473764664 1080 6794277 SGTC_319 1348-1596 45.5 µM -2.25697544526423 0.00853711924618675 no 3316 0.0120048045665277 1076 5380505 SGTC_2203 7227154 166.4 µM -2.28288483848717 0.00792889611302001 no 3317 0.0112185763984376 1079 896304 SGTC_2403 6032726 181.2 µM -2.30551157007731 0.00742924788894764 no 3318 0.0105689697599489 1076 2881040 SGTC_2507 purpurin 79.67 µM -2.33528762156569 0.00681411332881202 no 3319 0.00976420019351965 1073 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1238 0333-0287 48.8 µM -2.34950008129573 0.00653669902899543 no 3320 0.00939932000248125 1077 7226 SGTC_1820 st053765 18.6 µM -2.36364596803195 0.00627055014021927 no 3321 0.00904804816410516 1076 3690829 SGTC_1356 1502-0781 85.8 µM -2.3662769918316 0.0062221206950927 no 3322 0.00898399779970494 1084 567702 SGTC_2833 9001315 45.46 µM -2.37277541094547 0.00610392055868604 no 3323 0.008827497708925 1065 2989378 SGTC_3077 9117319 49.47 µM -2.37479215337884 0.00606764466550473 no 3324 0.00877941722467408 1079 17154678 SGTC_638 3970-0837 4.09 µM -2.38970449761923 0.00580528845219057 no 3325 0.0084309668359238 1077 4118451 YLR208W SEC13 SGTC_2867 9039098 71.43 µM -2.38972126696329 0.00580499918167763 no 3326 0.00843058192752647 1059 6463460 SGTC_3250 9135583 49.47 µM -2.41256935376592 0.00542255112246815 no 3327 0.00792026172247475 1082 7699353 SGTC_2417 cerulenin 830 nM -2.42384972989361 0.00524212327245332 no 3328 0.00767847927510747 1078 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_533 1222-0222 6.71 µM -2.46658116804829 0.0046061223765291 no 3329 0.00682049042100487 1085 3982874 SGTC_1728 st035614 33.7865 µM -2.48372867817799 0.00437091049732838 no 3330 0.00650074133415615 1079 15945546 SGTC_2832 7992762 51.95 µM -2.52603363509825 0.003835882312077 no 3331 0.00576792180971874 1064 2985177 SGTC_125 0133-0007 11.75 µM -2.57968897024351 0.00324208391561122 no 3332 0.00494446685793473 1086 26541 SGTC_3078 9116413 49.47 µM -2.63681183099496 0.00270198724697475 no 3333 0.00418446203998665 1078 17177322 SGTC_1726 st035556 14.5795 µM -2.66333093569247 0.00248003525593943 no 3334 0.00386856401499911 1080 5919439 SGTC_1964 st076914 61 µM -2.67560228719801 0.00238302271718007 no 3335 0.0037297553342432 1091 24208661 SGTC_2136 5328288 199.296 µM -2.68225959159254 0.00233184200629972 no 3336 0.00365633453088734 1085 262395 SGTC_114 0364-0001 490.298 µM -2.69665589465178 0.00222455210828856 no 3337 0.00350198024201201 1089 4003655 SGTC_1829 berberine 14.4 µM -2.72314801476353 0.00203873645080871 no 3338 0.00323315398952034 1046 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_126 0417-1624 672.48 µM -2.72987055518947 0.00199388210049997 no 3339 0.00316795991762496 1082 41912 YDL195W SEC31 SGTC_2872 9044037 25.97 µM -2.74175002137076 0.00191680473742531 no 3340 0.00305564156342294 1091 6465195 SGTC_1960 st011366 51.8 µM -2.75777296235755 0.00181713114837945 no 3341 0.00290983011956754 1086 3972846 SGTC_329 k048-0121 21.3 µM -2.7763394627903 0.00170754484402704 no 3342 0.00274873883086978 1094 6832902 SGTC_750 4073-0104 132 µM -2.80427579461053 0.00155395861053478 no 3343 0.00252148738035843 1049 22330957 SGTC_1549 4'-methoxyflavonol 74.6 µM -2.82778754115328 0.0014345764835319 no 3344 0.00234354508216654 1093 97141 SGTC_2604 4'-hydroxychalcone 11.32 µM -2.93745468502019 0.000980796564116712 yes 3345 0.00165459264912549 1089 5282362 SGTC_2105 5350118 200 µM -3.08945298042939 0.000567409862979885 yes 3346 0.00100262722199124 1089 2133313 SGTC_1670 st016595 4.04 µM -3.11558694143472 0.000515226926958104 yes 3347 0.000917896115207058 1094 597879 SGTC_2383 9036125 200 µM -3.16104988721773 0.000434898922241442 yes 3348 0.000786007860771126 1090 79580 SGTC_1957 st077035 62.4 µM -3.23388467009763 0.000330021411516336 yes 3349 0.000610593792800865 1095 705593 SGTC_1822 st052468 42 µM -3.30400461896113 0.000251726096946187 yes 3350 0.000476571309184741 1093 2873678 SGTC_778 3456-2434 196 µM -3.42108519622664 0.000158361068399427 yes 3351 0.000311858950901181 1013 5539063 SGTC_2614 arthonioic acid 13.39 µM -3.49022212754442 0.000119648703175859 yes 3352 0.000241309609763717 1088 6710684 SGTC_2868 9035608 32.47 µM -3.69234656768279 5.12482046830238e-05 yes 3353 0.000111097196500724 1094 6462614 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -3.76055472613197 3.812983085393e-05 yes 3354 8.47684891687196e-05 1092 6708514 SGTC_2388 9080168 200 µM -3.92847954769213 1.80368347393796e-05 yes 3355 4.27423096182469e-05 1095 15943073 SGTC_1107 amlodipine 47 µM -4.32229263889799 2.77697408588087e-06 yes 3356 7.72080940541343e-06 1069 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.