SGTCid condition conc unit MTC2|YKL098W.score MTC2|YKL098W.strain.pval MTC2|YKL098W.strain.significant MTC2|YKL098W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1750 st081859 2.357 µM 24.2731384076529 3.82263650473992e-112 yes 1 1.88407886741498e-130 8 5291695
SGTC_568 1193-0097 7.48 µM 13.8590564330103 8.25741380468337e-38 yes 2 5.60693252735934e-44 6 3646150
SGTC_1128 3448-9350 235 µM 7.75577993975165 5.01076028452343e-13 yes 3 4.39010821639381e-15 2 619386
SGTC_1132 3456-3614 2.5 µM 7.12188107453138 3.04740786662769e-11 yes 4 5.32319519955529e-13 7 3125502
SGTC_742 0kpi-0133 140 µM 6.83741259082835 1.72411030800085e-10 yes 5 4.03181286550304e-12 4 2728852
SGTC_87 0100-0052 35.5 µM 6.6881372966993 4.165297946197e-10 yes 6 1.13014517091194e-11 22 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_736 0958-0254 92.6 µM 6.37417547527275 2.50464331563413e-09 yes 7 9.19749404471585e-11 3 6812352
SGTC_1012 4112-3522 18 µM 6.26678423862668 4.53909554923366e-09 yes 8 1.84290145530542e-10 3 3112398
SGTC_2401 5128683 200 µM 5.92403232169821 2.83776863901951e-08 yes 9 1.57070835283307e-09 11 708373
SGTC_1161 k007-0610 110 µM 5.60268315367833 1.44688057729759e-07 yes 10 1.05529413244701e-08 62 5843850
SGTC_402 epigallocatechin gallate 10 µM 5.49433935695179 2.45752874880575e-07 yes 11 1.96087861528112e-08 3 65064 An antioxidant.
SGTC_2066 5222451 176 µM 5.436053910942 3.25465965549318e-07 yes 12 2.72367396767837e-08 12 2281147
SGTC_2973 9094665 17.96 µM 5.30177553798393 6.15038626331466e-07 yes 13 5.73408967171432e-08 8 25237061 YIL048W NEO1
SGTC_1926 methyl fluorone black 53.6 µM 5.28721247433819 6.58394927086176e-07 yes 14 6.2097177092436e-08 29 72721 Reacts with homocysteine.
SGTC_1866 st057638 64 µM 5.23787715051374 8.28206002545898e-07 yes 15 8.12170609297086e-08 6 688802
SGTC_115 0527-0192 112.043 µM 5.23076343378758 8.55922977318136e-07 yes 16 8.44057123609541e-08 26 4233931
SGTC_3339 9145883 14.936 µM 5.17949369188497 1.08375113508714e-06 yes 17 1.11244467914589e-07 4 2030670
SGTC_56 0957-0365 83.25 µM 5.12405277331285 1.39538595343806e-06 yes 18 1.49518612875956e-07 26 6752360
SGTC_8 0354-0001 70 µM 5.02098510299692 2.21719558901844e-06 yes 19 2.57035734106479e-07 42 4993152
SGTC_3235 9132602 49.47 µM 4.95306807279801 2.99386428663774e-06 yes 20 3.65262021406713e-07 10 4912240
SGTC_2286 7945697 125 µM 4.94690994254802 3.07592684074077e-06 yes 21 3.77004193024884e-07 29 1245733
SGTC_184 1494-0393 24.714 µM 4.70989993701236 8.50346191606231e-06 yes 22 1.23919219005598e-06 40 3090647
SGTC_126 0417-1624 672.48 µM 4.70818617953126 8.56476537883688e-06 yes 23 1.24965387647243e-06 15 41912 YDL195W SEC31
SGTC_2481 5478948 45.16 µM 4.63860810466057 1.14415301946215e-05 yes 24 1.75381724499783e-06 21 77792
SGTC_113 0099-0221 2.5 µM 4.60966989064632 1.28908370804834e-05 yes 25 2.01654421772301e-06 12 89219
SGTC_1574 spiramycin 23.7 µM 4.60522496363767 1.31283626907546e-05 yes 26 2.06010103491705e-06 14 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3018 9082602 49.47 µM 4.52365928274699 1.83004208877218e-05 yes 27 3.03897698606676e-06 44 17332089
SGTC_2006 4011487 200 µM 4.46059630844654 2.35698143823807e-05 yes 28 4.08659595498592e-06 68 45595294
SGTC_1658 st012944 20 µM 4.43855285632506 2.57296589805915e-05 yes 29 4.52828725087246e-06 63 24207260
SGTC_1457 k015-0032 57.3 µM 4.34393974187459 3.73161115361436e-05 yes 30 6.99749590507429e-06 28 4302660
SGTC_2711 st079103 59.1 µM 4.27697326359874 4.83333281805897e-05 yes 31 9.47257730148992e-06 6 54693780
SGTC_2291 7917025 104.35 µM 4.24996555706972 5.35926509431582e-05 yes 32 1.06901694649062e-05 41 2964612
SGTC_2967 9089538 49.85 µM 4.20223219273395 6.42321613638509e-05 yes 33 1.32147916728153e-05 26 728216
SGTC_660 4031-1742 102 µM 4.19530325762678 6.59327924454491e-05 yes 34 1.36253369510359e-05 41 6738706
SGTC_3152 9099253 49.47 µM 4.1412826362213 8.07227996964697e-05 yes 35 1.72684534708846e-05 119 25236131
SGTC_3280 9140961 49.47 µM 4.11835557188028 8.78994503207145e-05 yes 36 1.9079280212167e-05 12 4901226
SGTC_1706 st031321 9.9705 µM 4.09737966975159 9.49870668026717e-05 yes 37 2.08926625830071e-05 12 6103185
SGTC_1663 st014140 55.4 µM 4.04945624481493 0.000113245904227078 yes 38 2.56683873693417e-05 14 4207120
SGTC_2777 climbazole 1.536 µM 4.00351731151943 0.000133799132813678 yes 39 3.12038160798436e-05 49 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_91 0417-1751 58.384 µM 3.97948659083331 0.000145896132540418 yes 40 3.45321276008936e-05 53 6795624
SGTC_723 4182-0001 115 µM 3.92329507912956 0.00017829685791036 yes 41 4.36730309476101e-05 29 744821 YLR208W SEC13
SGTC_3281 9140613 49.47 µM 3.90271620015987 0.000191761922759637 yes 42 4.7559604564365e-05 21 16013766
SGTC_535 2293-4129 48.2 µM 3.88814545931321 0.000201864136226796 yes 43 5.0506543318188e-05 62 396118 YIL048W NEO1
SGTC_1239 0337-0584 35.4 µM 3.82803610069989 0.000249027631802866 yes 44 6.45849069408398e-05 61 914301 YML130C ERO1
SGTC_562 3772-2733 112 µM 3.75860183028509 0.000316223196070705 yes 45 8.54327487558856e-05 89 2876874 YIL048W NEO1
SGTC_2309 7664088 163.95 µM 3.75119722663511 0.00032430754059073 yes 46 8.79960945553924e-05 41 704922
SGTC_542 3381-0244 89.3 µM 3.73723316803474 0.000340078955081577 yes 47 9.30281854577053e-05 46 1112843
SGTC_59 0330-0160 1.33 µM 3.72248053099587 0.000357513475946331 yes 48 9.86375622286196e-05 127 4293482
SGTC_2084 5306078 60.6385 µM 3.71549413503939 0.000366056487606905 yes 49 0.000101403484888851 26 679340
SGTC_3027 9089541 49.47 µM 3.71277109578195 0.000369437299793053 yes 50 0.000102501142853479 25 9943819
SGTC_2468 5987765 72.9 µM 3.7023627597739 0.000382628931834496 yes 51 0.000106800454989212 22 26772094
SGTC_263 alizarin 107.927 µM 3.67435274570962 0.000420332556226583 yes 52 0.000119226558166936 71 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_687 k029-0044 34.9 µM 3.65277025110742 0.000451704023004381 yes 53 0.000129713165377914 22 5829338
SGTC_2189 6047310 154.431 µM 3.64504778449245 0.000463446578175966 yes 54 0.000133671061722272 23 711535
SGTC_1174 0739-0097 51.1 µM 3.59941846949473 0.000538800415636716 yes 55 0.000159464802512994 46 728447
SGTC_3055 9094636 49.47 µM 3.48984764466987 0.000768347816694174 yes 56 0.000241647997075081 19 25236176
SGTC_2770 toltrazuril 17.5 µM 3.44746404975498 0.000879122284960041 yes 57 0.000282937855572002 44 68591 Kills coccidiodes.
SGTC_2998 9066762 71.4286 µM 3.41653054823617 0.000969041540579197 yes 58 0.000317122737211337 42 4945196
SGTC_1876 myriocin 605 nM 3.39997380155224 0.00102056772143534 no 59 0.000336961549344201 51 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3292 9120825 59.784 µM 3.39893309292069 0.00102388900260725 no 60 0.000338246316126897 27 24824900
SGTC_2950 9072895 21.46 µM 3.36889470244592 0.00112413277602824 no 61 0.00037735127249743 69 17332245
SGTC_2302 7771753 200 µM 3.35357246615877 0.00117865835734327 no 62 0.000398877605984623 69 2203047
SGTC_1002 4049-0206 172 µM 3.33212082075204 0.00125906902600095 no 63 0.000430934149584142 70 4662749
SGTC_1675 st018485 24.5 µM 3.32998268315149 0.00126735277507814 no 64 0.000434256926825764 55 3323024
SGTC_2463 5473429 200 µM 3.32834307814991 0.00127373880475279 no 65 0.000436821034396437 33 5399405
SGTC_1399 3562-5772 25 µM 3.32209511404144 0.00129834440981943 no 66 0.000446721163061172 28 23847490
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 3.31856979833352 0.00131241877111525 no 67 0.000452398533199858 49 2333 A French combination drug.
SGTC_2629 bisabolol 100 µM 3.27678186191333 0.0014902111105541 no 68 0.000524987272891267 48 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_717 1532-0246 73.2 µM 3.27029582150699 0.0015196978703651 no 69 0.000537175344545093 62 9561992
SGTC_1373 2887-0003 58.5 µM 3.24310057321155 0.00164921469175233 no 70 0.000591182331458954 44 776948
SGTC_1407 3909-7909 12.3 µM 3.23757868763431 0.00167671007914038 no 71 0.000602743451486109 41 4411780
SGTC_1903 st060211 78.3 µM 3.23055870178233 0.00171226752874012 no 72 0.000617742656643993 57 688960
SGTC_1493 4348-0038 111 µM 3.17121323538255 0.00204142171977909 no 73 0.000759018331520317 59 800424
SGTC_339 3091-4833 71.4 µM 3.1653680408759 0.00207676700145755 no 74 0.00077443449753835 38 3240077
SGTC_2071 5230951 39.92 µM 3.15023424135618 0.00217087398478733 no 75 0.000815698023370725 46 1799272
SGTC_2456 5770359 74.46 µM 3.14926497997947 0.00217703091203976 no 76 0.000818408527993347 37 3118787
SGTC_2546 rhodinyl acetate 100 µM 3.11402564246503 0.00241191484690674 no 77 0.000922767248695166 39 6708682
SGTC_3083 9117465 49.47 µM 3.09560895802919 0.00254358391685751 no 78 0.000982045982690588 65 16420915
SGTC_789 1309-1135 70.6 µM 3.06841473589762 0.00274990572693162 no 79 0.00107598864463051 72 3092424
SGTC_174 3553-0389 74.3 µM 3.05478811247662 0.00285886954041037 no 80 0.00112609788209144 53 738071
SGTC_650 1328-0195 38 µM 3.05151595188206 0.00288560811819218 no 81 0.00113844474841042 56 2780821
SGTC_904 1141-0088 396 µM 3.03879439372772 0.00299171849259424 no 82 0.00118763451299643 51 1378119
SGTC_2216 7189485 200 µM 3.0311382161893 0.00305726077578775 no 83 0.00121816846995647 16 731273
SGTC_3061 glucosamine 200 µM 3.02260788037409 0.00313180729503159 no 84 0.00125303369782541 36 91431 and experimental redox chemotherapeutic
SGTC_2545 solidagenone 89.61 µM 3.0177458304734 0.00317502506721768 no 85 0.00127331198599692 9 6708572 An anti ulcer agent
SGTC_2289 7946404 165.07 µM 3.00993417517072 0.00324558605018916 no 86 0.00130652156652968 160 1246120 YPR165W RHO1
SGTC_2552 juarezic acid 87.02 µM 2.96130687013014 0.00371743780076815 no 87 0.00153168274706901 85 1549512
SGTC_1874 staurosporine 7.6 µM 2.95664353733562 0.00376577409949507 no 88 0.00155503718504933 80 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1885 st057546 99.9 µM 2.95603106803745 0.00377216414674263 no 89 0.00155812849607126 57 702008
SGTC_1865 st057639 52.2 µM 2.91636021029518 0.00420735054009553 no 90 0.00177070689368146 54 688818
SGTC_2414 st077232 92.9 µM 2.90725370672288 0.00431337566470293 no 91 0.00182308672095488 76 729801
SGTC_768 0384-0033 77.3 µM 2.90706442297435 0.00431560456871535 no 92 0.00182419025938079 154 3965305 YMR134W ERG29
SGTC_1381 2324-0066 62.1 µM 2.90664860636562 0.00432050461771291 no 93 0.00182661663454257 84 10885928
SGTC_2108 5365811 200 µM 2.90523240548494 0.00433723068676595 no 94 0.00183490249171263 63 780283
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.90361339354113 0.00435642293888568 no 95 0.00184441680589105 74 688751
SGTC_1351 1496-0003 46.5 µM 2.89118660068145 0.00450627863566615 no 96 0.00191895083675471 67 3891978
SGTC_2704 st078022 71.1 µM 2.89043517015683 0.00451548605715739 no 97 0.00192354435672494 48 54697681
SGTC_2916 7875993 68.79 µM 2.88975996301445 0.00452377382386784 no 98 0.00192768043952218 85 1299250
SGTC_1211 1056-0033 32.3 µM 2.88636998780289 0.00456558937349202 no 99 0.00194856861472059 43 6741922
SGTC_2322 7413319 38.22 µM 2.8830923905565 0.0046063464543978 no 100 0.00196895961443926 245 1840400
SGTC_2333 9017922 200 µM 2.85254105398767 0.00500215513417989 no 101 0.00216856048745634 83 3163164
SGTC_131 0141-0277 33.849 µM 2.85108754491031 0.00502171927670006 no 102 0.00217849858551901 117 1547771
SGTC_2404 5161160 200 µM 2.8508895371623 0.00502438971608241 no 103 0.00217985561731159 80 2831543
SGTC_910 3454-3003 490 µM 2.84999995258737 0.00503640274464568 no 104 0.00218596178076921 79 820824
SGTC_125 0133-0007 11.75 µM 2.80140453228118 0.0057327696230344 no 105 0.00254403465903183 60 26541
SGTC_2966 9084041 48.03 µM 2.8011337079442 0.00573687882192136 no 106 0.00254617075009712 101 17741380
SGTC_3224 9130643 49.47 µM 2.7951497655041 0.00582834224968944 no 107 0.00259378385172431 97 17644395
SGTC_1503 4585-0012 61.3 µM 2.78896448044877 0.00592424062062449 no 108 0.00264384319576006 74 2922052
SGTC_1111 tnp00062 510.699 nM 2.77943415159309 0.00607474139505885 no 109 0.00272268462465994 57 676306
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.77864684037981 0.00608732464963388 no 110 0.00272929177345796 75 16486 A toxic proline analog.
SGTC_2883 9059145 45.46 µM 2.77241074063194 0.00618781226940262 no 111 0.00278213885668208 52 16476510
SGTC_1398 3558-0053 112 µM 2.7598961377887 0.00639391350963142 no 112 0.00289098702024627 42 4532369
SGTC_1029 k015-0030 64.7 µM 2.74831650894471 0.00659000403721989 no 113 0.00299510765079702 101 2208316
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.73654098162932 0.00679484646317287 no 114 0.00310444304081325 55 616764
SGTC_2820 7989630 71.43 µM 2.73365518497038 0.0068458968744659 no 115 0.00313177998985978 75 2984098
SGTC_1051 3253-3903 78 µM 2.72832343015441 0.0069411086186621 no 116 0.00318285797137598 101 5509239
SGTC_2164 5685496 200 µM 2.71337851723629 0.00721424666789254 no 117 0.00333004915211275 73 759046
SGTC_1965 Pectolinarigenin 58.4 µM 2.70574488554952 0.00735738508026345 no 118 0.00340756896418878 61 5320438 An anti-inflammatory.
SGTC_1774 st048371 48.465 µM 2.70517765014888 0.00736812056221657 no 119 0.00341339347841799 94 4242727
SGTC_3315 9136395 68.55 µM 2.69200693226143 0.00762130136009299 no 120 0.00355117344939592 73 16876844
SGTC_931 2812-0076 566 µM 2.67235642862877 0.00801328252789961 no 121 0.00376602988954748 108 3450959
SGTC_2815 7968870 71.43 µM 2.66372712729723 0.00819094490903835 no 122 0.00386401110767843 111 2977326 YHR190W ERG9
SGTC_2824 7998404 51.95 µM 2.65272483785401 0.00842247569466354 no 123 0.00399224655889755 109 837851
SGTC_551 k048-0028 34.9 µM 2.65156420483566 0.00844723172199712 no 124 0.00400599392658879 99 6836383
SGTC_1681 tripelennamine 100 µM 2.62978940371861 0.00892366751895212 no 125 0.00427188883307273 80 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_361 000s-0510 1.45 µM 2.62150506643966 0.00911101996490412 no 126 0.00437712305552014 134 660
SGTC_598 3937-0236 20.2 µM 2.6166818947265 0.00922167609650059 no 127 0.00443945218216227 133 1379313
SGTC_3098 9119039 49.47 µM 2.61093531409697 0.00935505178203948 no 128 0.00451474856258731 113 17161528
SGTC_2600 tangeritin 87.95 µM 2.6078358901238 0.00942768626900724 no 129 0.00455583132961149 112 68077 A bioactive flavone.
SGTC_71 0417-1750 47.813 µM 2.59501706313958 0.00973335701573898 no 130 0.0047293111571829 141 6811472
SGTC_2205 7238770 200 µM 2.58750685372512 0.00991643481385458 no 131 0.00483366362236354 56 279867
SGTC_2882 9058044 58.44 µM 2.58660632837674 0.00993858769743016 no 132 0.00484631301334111 92 18076804
SGTC_1556 plumbagin 1.48 µM 2.58306595424282 0.0100261001050067 no 133 0.00489633002512962 79 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_676 falcarinol 140 µM 2.57938002571054 0.0101179242313267 no 134 0.00494889165374131 136 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_17 0960-0276 49.807 µM 2.55992650080993 0.0106148061018558 no 135 0.00523471513729736 146 6821114
SGTC_1066 ketoconazole 628 nM 2.55784892419637 0.010669107316121 no 136 0.00526609187264425 108 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2138 5575593 77.673 µM 2.55616986291126 0.0107131692204369 no 137 0.00529157212552626 73 762213
SGTC_1807 st050092 58.9 µM 2.55564089353281 0.0107270832113794 no 138 0.0052996220758829 93 5008496
SGTC_1790 st045711 43.5 µM 2.55406404046102 0.0107686541035298 no 139 0.0053236835719323 88 585119
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.55126476358981 0.0108427975663529 no 140 0.00536663766299445 113 115019
SGTC_1887 st057648 70.8 µM 2.52950023854791 0.0114345772787103 no 141 0.00571125481810856 93 688672
SGTC_889 0919-1524 82.7 µM 2.52301574623832 0.0116162312459497 no 142 0.0058176595427951 94 3905452
SGTC_509 pifithrin 175 µM 2.51249879100122 0.0119161772906013 no 143 0.00599397579299488 68 4817 A p53 inhibitor.
SGTC_645 0845-0943 5.41 µM 2.50822885591187 0.012039861096845 no 144 0.00606690258845213 90 1885106
SGTC_851 0394-0702 453 µM 2.49984565125761 0.0122859317788969 no 145 0.00621237131895258 98 762646
SGTC_2245 6637752 200 µM 2.49728481753827 0.0123619631166802 no 146 0.00625741969520473 72 681890
SGTC_3193 9111931 49.47 µM 2.48903699167508 0.012609618436256 no 147 0.00640448187887012 109 17087244
SGTC_1531 st059297 52.4 µM 2.48726165341369 0.0126634842100669 no 148 0.00643653404850539 111 7566702
SGTC_392 N-ethylmaleimide 8.33 µM 2.47796992779342 0.0129486659073798 no 149 0.00660661406712287 107 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1511 0906-3109 28.5 µM 2.47738684530462 0.0129667456048389 no 150 0.00661741837694978 198 2882180
SGTC_2457 5731572 11.68 µM 2.46937724632568 0.013217317883097 no 151 0.00676742234507885 73 2865357
SGTC_362 0310-0100 9.03 µM 2.46887482543605 0.0132331741203135 no 152 0.00677693105320711 143 790235
SGTC_1433 4060-0023 7.6 µM 2.46215263929651 0.0134469101103835 no 153 0.00690529386813102 102 3840627
SGTC_1796 st049173 110.4 µM 2.45742512061614 0.0135990037287012 no 154 0.00699684899359631 69 94134
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.45358505032768 0.0137236368971929 no 155 0.00707200438791741 173 688788
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.44462137063914 0.0140184022722642 no 156 0.00725021410324555 80 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1021 4476-0760 85.3 µM 2.43639593515383 0.0142936763366571 no 157 0.00741721859630668 144 746768
SGTC_1925 st057770 10.1 µM 2.43509694591844 0.0143375715018172 no 158 0.00744390016943438 108 5989122
SGTC_2569 tetrandrine 100 µM 2.41900328153967 0.0148911060297218 no 159 0.00778154990523026 129 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_894 0960-0238 55.9 µM 2.41888678131868 0.0148951790667599 no 160 0.00778404245728447 87 6741907 YDL195W SEC31
SGTC_2094 5332512 191.667 µM 2.41850783917264 0.0149084341256796 no 161 0.00779215488118087 141 755774
SGTC_754 3474-0146 171 µM 2.41738514411709 0.0149477645471215 no 162 0.00781623331256557 136 24762078
SGTC_2028 5153890 36.43 µM 2.40970065037215 0.0152193710643166 no 163 0.00798280711326137 130 2830968 YPR165W RHO1
SGTC_1305 1181-0477 144 µM 2.37932567494056 0.0163348573905636 no 164 0.00867217230242239 124 6252086
SGTC_3112 9123419 49.47 µM 2.37210719699301 0.0166100159891612 no 165 0.00884347919757184 137 17015854
SGTC_2982 9019404 25.97 µM 2.37120563977471 0.0166446591858905 no 166 0.00886508167601241 139 22333232
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.36769050930278 0.0167803225186307 no 167 0.00894975102642289 145 5282309
SGTC_696 1560-0013 611 µM 2.36141197079245 0.0170249910950814 no 168 0.00910274679051722 145 1650269
SGTC_1937 st074714 47.2 µM 2.35275284818684 0.0173674273466198 no 169 0.00931750775962912 160 17250970
SGTC_785 1270-0111 65.3 µM 2.34581556235331 0.0176459993681547 no 170 0.00949274982992063 161 6741994
SGTC_1366 1683-0113 21.9 µM 2.32970609269115 0.0183076302342385 no 171 0.00991084515630924 115 708623
SGTC_1626 st003712 1.76 µM 2.32778862514626 0.0183877722954291 no 172 0.00996166518898753 143 24207035
SGTC_2275 7947463 200 µM 2.32345447849461 0.0185700230779782 no 173 0.0100773751975861 127 1225414
SGTC_2312 7706453 155.7 µM 2.32004775842311 0.0187143530199855 no 174 0.010169146965699 152 976098
SGTC_1705 st027868 56.3335 µM 2.29618643966949 0.0197522706120354 no 175 0.0108326117757339 118 292948
SGTC_1104 tacrolimus 29.8 µM 2.2809431450696 0.0204405823101522 no 176 0.011275905717063 164 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_145 3737-0113 38.366 µM 2.26871339311371 0.0210074142393276 no 177 0.011642880305301 252 6849351
SGTC_292 k038-0015 474 µM 2.26388229387318 0.0212349657005767 no 178 0.0117906776197442 129 46368540
SGTC_1093 fluphenazine 7.97 µM 2.26224096759408 0.0213127473759175 no 179 0.01184125972476 154 6602611 An atypical antipsychotic.
SGTC_508 roscovitine 141 µM 2.25937647266392 0.021449071585935 no 180 0.0119299883149397 97 160355 A CDKinase inhibitor.
SGTC_610 4215-0184 155 µM 2.24197793057151 0.0222930149912727 no 181 0.012481399346391 160 5605015
SGTC_1880 MG-132 525 µM 2.2368984171532 0.0225446255277166 no 182 0.0126464900213489 128 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_406 estrone 100 µM 2.23341934804893 0.0227183371828645 no 183 0.0127606517259842 129 5870 A steroid.
SGTC_2306 7482397 179.52 µM 2.23005601381427 0.0228873411988083 no 184 0.0128718622366172 155 891448
SGTC_1634 st006576 41 µM 2.22541371076581 0.0231223509736914 no 185 0.0130267389782999 169 3915356
SGTC_958 1222-0007 33 µM 2.22112073315524 0.0233414817034208 no 186 0.0131713925578382 187 7312461
SGTC_288 1315-0019 35.1 µM 2.21514482498103 0.0236494235215027 no 187 0.0133750627841125 165 6811474
SGTC_2674 ligustilide 100 µM 2.20669932261803 0.0240904455028477 no 188 0.0136675363027053 114 5319022 A signalling regulator.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.20651757104654 0.0241000119605226 no 189 0.0136738906666747 165 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_881 0833-0569 170 µM 2.20602118892044 0.0241261551964223 no 190 0.0136912580732379 186 5418700
SGTC_2160 5660466 132.927 µM 2.20521694865018 0.024168563136907 no 191 0.0137194372107833 154 2859134
SGTC_2784 7567673 72.73 µM 2.20425813865323 0.024219203410353 no 192 0.0137530975654524 217 3471247
SGTC_519 k048-0011 62.8 µM 2.20216980620786 0.0243298087452382 no 193 0.0138266580080435 162 6836379
SGTC_1424 4048-1941 275 µM 2.2018446315427 0.0243470692277841 no 194 0.0138381425971271 179 X1424
SGTC_1895 st058434 18.3 µM 2.19862926060749 0.024518297334652 no 195 0.0139521473134083 157 5393175
SGTC_2093 5331342 194.4 µM 2.19611521078964 0.0246528810429228 no 196 0.0140418490661611 152 33839
SGTC_3356 9151811 4.48 µM 2.19348172298036 0.02479452273789 no 197 0.0141363450018061 172 1859254 YPR165W RHO1
SGTC_1030 k029-0042 36.7 µM 2.18978904579148 0.0249942818377347 no 198 0.0142697697717553 200 6080581
SGTC_1058 3448-5425 97.3 µM 2.18117311326615 0.0254656210701879 no 199 0.0145853073431877 186 7279705
SGTC_745 0469-0705 296 µM 2.18093690085295 0.0254786473273638 no 200 0.0145940419458956 200 3486736
SGTC_510 ag-490 170 µM 2.18048656256829 0.0255034973101059 no 201 0.0146107069126055 98 5328779
SGTC_2366 9070441 60.58 µM 2.17328380360398 0.025903716835026 no 202 0.014879481864595 197 6837235
SGTC_1971 st069429 63.5 µM 2.17118281342944 0.0260214430154077 no 203 0.0149586779920366 136 1246522 YGL099W LSG1
SGTC_2157 5649910 96.377 µM 2.17043858688207 0.0260632519546214 no 204 0.0149868181451317 184 2858091
SGTC_2017 5132927 60.65 µM 2.16229419983162 0.0265244676280432 no 205 0.0152977532617543 198 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_302 1094-0063 18.9 µM 2.15548429189647 0.0269153284437985 no 206 0.0155619782669377 131 5440289
SGTC_397 arbidol 50 µM 2.15511291065648 0.0269367817403233 no 207 0.0155764998291424 182 131410 A RNA synthesis inhibitor.
SGTC_3087 9117406 49.47 µM 2.15327350095052 0.0270432480526489 no 208 0.0156485950518767 167 42546093
SGTC_644 1498-1197 63.3 µM 2.14619267211277 0.0274563747151868 no 209 0.0159288049918225 201 6741615
SGTC_588 3970-1144 52.9 µM 2.13960157287847 0.0278456443716031 no 210 0.0161934897025647 205 1888707
SGTC_94 0334-0113 514.748 µM 2.13376154668877 0.0281943872273411 no 211 0.0164311525471428 181 6795178
SGTC_379 3970-0972 5.9 µM 2.12474163799984 0.0287401592898043 no 212 0.0168040885250414 198 2898042 YBL034C STU1
SGTC_2943 9068529 45.32 µM 2.12368626189334 0.0288045876960075 no 213 0.0168481934590578 202 3270634
SGTC_2694 st077685 81.9 µM 2.12291426476483 0.0288517924396592 no 214 0.0168805184414601 208 2838096
SGTC_581 0958-0271 211 µM 2.12268653031592 0.0288657298283703 no 215 0.0168900642385553 265 4591145
SGTC_1254 0550-0035 264 µM 2.11976748841555 0.0290448718545623 no 216 0.0170128291726243 189 15121435
SGTC_2175 5807670 165.306 µM 2.10943036164026 0.0296867066950086 no 217 0.0174537255389939 167 241186
SGTC_2129 girgensonine 121.053 µM 2.10377636660137 0.0300427154882309 no 218 0.0176989796448435 223 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2944 9067346 25.62 µM 2.10148378716807 0.030188075021765 no 219 0.0177992598629857 229 6473075
SGTC_1190 1486-1332 13 µM 2.10083307357319 0.0302294391605542 no 220 0.0178278110282826 189 4150046
SGTC_3347 9188721 44.724 µM 2.09729332022814 0.0304552755318694 no 221 0.0179838089086695 158 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_771 0250-0039 27.3 µM 2.08685208826714 0.03112958148472 no 222 0.0184507534820153 176 3005115
SGTC_1727 st034309 9.9045 µM 2.08160201453838 0.0314732757274254 no 223 0.0186894186276976 275 870305
SGTC_2987 9018338 71.43 µM 2.08029013153108 0.0315596458335879 no 224 0.0187494647048737 219 5055682
SGTC_1145 3546-0597 10.2 µM 2.07543900108214 0.031880731734705 no 225 0.01897293336496 213 875334
SGTC_1627 st003713 25.6 µM 2.06863862226744 0.0323353721128212 no 226 0.0192900054012152 326 16195070 YER133W GLC7
SGTC_496 calpeptin 138 µM 2.06146962297406 0.0328204361925049 no 227 0.0196291293082223 193 73364 A calpain inhibitor.
SGTC_1172 0370-0043 85 µM 2.0547237703754 0.0332823321889985 no 228 0.0199528463352744 175 376585
SGTC_634 1611-4317 11.2 µM 2.05086339746838 0.0335490559485304 no 229 0.020140125765197 221 2843522
SGTC_380 3970-0968 6 µM 2.04318072019415 0.0340851089066616 no 230 0.0205172757804875 197 2891601
SGTC_1980 st071811 45.7 µM 2.04134121382454 0.0342144987052054 no 231 0.0206084616114168 191 4974850
SGTC_2762 leflunomide 42.06 µM 2.04062744415194 0.034264813452088 no 232 0.0206439360834909 238 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2040 5100729 123 µM 2.0394230471645 0.0343498511700408 no 233 0.020703912081664 223 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2412 st077135 33.4 µM 2.02644316083716 0.0352773623776174 no 234 0.0213596958994346 235 13258915
SGTC_61 0978-8327 98.565 µM 2.02478103804965 0.0353976037319722 no 235 0.0214449264962861 231 6150059 YHR072W ERG7
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 2.01950899278969 0.0357812196861069 no 236 0.0217171717896298 238 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2223 6903751 107.57 µM 2.01882835666581 0.0358309929751299 no 237 0.021752531331972 144 5598863
SGTC_1949 st076024 69.1 µM 2.01188198886946 0.0363422150540945 no 238 0.0221161892240438 227 2921930
SGTC_303 1348-1668 34.2 µM 2.01071255491053 0.036428864576476 no 239 0.0221779135674212 167 5380509
SGTC_62 0180-0423 3.232 µM 2.00732286260668 0.0366809804098851 no 240 0.0223576481593956 214 30102 YGL099W LSG1
SGTC_803 4488-1585 147 µM 1.99823270330936 0.0373641330206897 no 241 0.022845718785693 187 747204
SGTC_121 0557-0495 61.343 µM 1.99737241081794 0.0374293214057366 no 242 0.0228923712834459 350 3104427
SGTC_2389 9091542 195.52 µM 1.98298054986644 0.0385337011327259 no 243 0.023684801083453 249 3626624 YOL127W RPL25
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.97976279509372 0.0387842178446541 no 244 0.0238650943883813 483 16725076
SGTC_2083 5306046 65.942 µM 1.97718261329094 0.0389860536426507 no 245 0.0240104960940952 264 539837
SGTC_662 k832-1615 104 µM 1.97435996134766 0.039207835495459 no 246 0.0241704136598266 212 5878478
SGTC_529 4076-0302 30.3 µM 1.97110272001209 0.0394650389978534 no 247 0.0243560638442272 217 5816522
SGTC_548 1436-0017 110 µM 1.96971018968402 0.0395754162328637 no 248 0.0244357972508182 277 9677137
SGTC_3255 9139072 49.47 µM 1.96850486671071 0.0396711572942967 no 249 0.024504988351385 208 17646060
SGTC_2409 alverine citrate 63.97 µM 1.95545962273566 0.0407194623994042 no 250 0.025264422341845 272 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_96 0929-0093 37.281 µM 1.95224303828989 0.0409813699398116 no 251 0.0254546783382877 217 6991579
SGTC_680 0417-1641 114 µM 1.94318365465672 0.0417263721500213 no 252 0.0259969861426488 214 2835990
SGTC_171 k064-0041 9.68 µM 1.94271351340393 0.0417653318637354 no 253 0.0260253912816529 190 53325
SGTC_1016 4226-1401 38 µM 1.93906434121713 0.0420687345604783 no 254 0.0262467520288016 248 2901613
SGTC_1300 1094-0077 113 µM 1.92889783926414 0.0429234237982715 no 255 0.0268717730678651 217 5532636
SGTC_1846 st056244 14.8 µM 1.9276927147361 0.043025661295437 no 256 0.0269466794036596 266 5393182
SGTC_2343 7990716 14.84 µM 1.92764285369601 0.0430298955228069 no 257 0.0269497823430794 234 6456862
SGTC_331 k048-0133 24.5 µM 1.92422119746949 0.0433212696528985 no 258 0.0271634316022126 192 6813582
SGTC_1982 st072467 71.9 µM 1.92097333279432 0.0435993162082899 no 259 0.027367534765078 290 3163533
SGTC_205 1486-1330 71.903 µM 1.91574356047541 0.0440500569012386 no 260 0.0276988724258544 181 4118834
SGTC_1506 4226-2149 212 µM 1.90819557936164 0.0447072150796047 no 261 0.028182971389895 293 991114
SGTC_977 1348-1378 135 µM 1.90512559783186 0.0449767489428718 no 262 0.0283818733470783 247 X977
SGTC_1560 lithocholic acid 53.1 µM 1.90470265066701 0.0450139845550904 no 263 0.028409367128293 150 9903 A bile acid which acts as a detergent.
SGTC_3279 9140807 49.47 µM 1.89975664151586 0.0454512676842451 no 264 0.0287325316733216 202 45595718
SGTC_1474 0330-0125 5.35 µM 1.89749072145289 0.0456527384743816 no 265 0.0288816011146183 234 X1474
SGTC_2331 7980721 200 µM 1.89674511302795 0.0457191898664553 no 266 0.0289307932565488 273 2981221
SGTC_3270 9137563 49.47 µM 1.89563144429554 0.0458185889266541 no 267 0.0290043981577154 207 17015724
SGTC_2261 9010538 184.68 µM 1.8931213357884 0.0460432623008791 no 268 0.0291708677150614 202 6457250
SGTC_1871 st057448 67.3 µM 1.8709265957067 0.0480685840573899 no 269 0.0306776280372155 276 691747
SGTC_2335 9018011 154.17 µM 1.86209502073381 0.0488940565047976 no 270 0.0312948488765146 284 6458208
SGTC_85 0868-0259 160.055 µM 1.85910660314162 0.0491759301066918 no 271 0.031506014756374 210 83173
SGTC_128 0906-2981 13.371 µM 1.85617313062397 0.0494538819032552 no 272 0.0317144423207682 217 6740226
SGTC_1900 st060200 72.8 µM 1.856081334395 0.0494625999546182 no 273 0.0317209829183465 245 688945
SGTC_1671 st016596 74.5 µM 1.8512562574415 0.0499225756027518 no 274 0.032066347904954 284 2829167
SGTC_2013 4024628 200 µM 1.85079732683201 0.0499665026468123 no 275 0.0320993579006849 283 5230760
SGTC_2549 cedrol 20.94 µM 1.84995099854663 0.0500475907117345 no 276 0.0321603062392567 203 6708665 A sedative which affects the nervous system.
SGTC_1600 coumarin 106 71.1 µM 1.84866010611515 0.0501714752170895 no 277 0.0322534538258036 285 100336 A hepatotoxic, DNA x-linker.
SGTC_578 3460-0051 92 µM 1.84662880593471 0.0503669101065703 no 278 0.0324004781749973 299 2876744
SGTC_2874 9043904 71.43 µM 1.84309522801158 0.0507083268307539 no 279 0.0326575539790913 204 4463428
SGTC_2856 9022925 19.48 µM 1.84101724489232 0.0509099620255539 no 280 0.0328095158068769 288 4944862
SGTC_3097 9117246 49.47 µM 1.83879239854931 0.0511265549655701 no 281 0.0329728633692395 281 16423892
SGTC_1669 st015249 58.4 µM 1.83337905693214 0.0516566169653465 no 282 0.0333731099533966 228 722793
SGTC_1194 1488-0194 225 µM 1.82856897866745 0.0521312660759604 no 283 0.0337321017156791 313 1391452
SGTC_3148 9097893 49.47 µM 1.82041929361865 0.052943361391668 no 284 0.0343475882367061 299 17174100
SGTC_3177 9107506 49.47 µM 1.81889811206297 0.053096048628712 no 285 0.0344634879693252 196 8897194
SGTC_1849 st056239 19.2 µM 1.81727739116396 0.053259110994806 no 286 0.0345873250097868 309 5393181
SGTC_2963 9082507 9 µM 1.81613339744124 0.0533744481553623 no 287 0.0346749558534149 266 16459611
SGTC_220 paclitaxel 373.376 µM 1.81159136554385 0.053834328966282 no 288 0.0350246800420083 210 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3011 9081274 71.4286 µM 1.80414855936544 0.0545946903376534 no 289 0.0356040104879779 302 6625322
SGTC_185 k048-0037 25.491 µM 1.8027630682666 0.0547371659985298 no 290 0.035712716287974 253 6827589
SGTC_274 sirtinol 40.1 µM 1.80206035348005 0.0548095412723715 no 291 0.0357679552548423 274 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2897 9048598 12.99 µM 1.80193704092733 0.0548222495002141 no 292 0.0357776558188329 246 6467404
SGTC_2162 5663267 200 µM 1.80124657817006 0.0548934495906369 no 293 0.0358320119286182 247 6456493
SGTC_1505 k297-0037 20.6 µM 1.80110042392494 0.0549085302936304 no 294 0.0358435264735829 295 4089396
SGTC_637 1181-0519 7.26 µM 1.79831794116898 0.0551962615405391 no 295 0.0360633191020617 414 6252091 YGR060W ERG25
SGTC_455 paf C-16 10 µM 1.78745871519719 0.0563306024990932 no 296 0.0369316895320125 264 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3024 9090631 49.47 µM 1.78649286631882 0.0564323773089438 no 297 0.0370097456239016 226 25236383
SGTC_1228 0124-0032 52.5 µM 1.78204893900145 0.0569025177689502 no 298 0.0373706257100988 305 X1228
SGTC_271 rotenone 740 µM 1.78090448543315 0.0570240920614065 no 299 0.0374640278743191 329 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1080 nisoldipine 24.4 µM 1.7779096825846 0.0573431951404181 no 300 0.0377093448548882 303 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2044 5102272 200 µM 1.77184458859475 0.0579937476211886 no 301 0.0382101793300318 239 592666
SGTC_3164 9100705 49.47 µM 1.76207126397538 0.0590542391841935 no 302 0.0390286288587413 220 17174235
SGTC_1463 k081-0032 34.1 µM 1.75772901055262 0.0595302659289215 no 303 0.0393968146145623 208 977755
SGTC_1076 itraconazole 331 nM 1.75661543238506 0.0596528270289499 no 304 0.0394916903655105 302 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2524 avocatin b 10.57 µM 1.75622826799877 0.0596954848722258 no 305 0.0395247198950381 256 6710748
SGTC_923 1900-2434 73.3 µM 1.74939520982211 0.060452292469431 no 306 0.0401113641584148 308 5910570
SGTC_1185 1319-0113 81.3 µM 1.74753091834855 0.0606600736128403 no 307 0.0402726432858173 270 4672763
SGTC_2610 ononetin 44.17 µM 1.74413572720345 0.0610399129061518 no 308 0.0405677127484941 373 259632
SGTC_3073 9114972 49.47 µM 1.7418481695517 0.0612968815072803 no 309 0.0407675076693784 264 41905075
SGTC_1471 k673-0312 37 µM 1.73262496516745 0.0623415357478329 no 310 0.0415811744951422 282 24099884
SGTC_1271 0832-2808 169 µM 1.72546003410933 0.0631626034673128 no 311 0.0422223001441029 317 3663794
SGTC_1267 0828-0272 9.49 µM 1.72393586595863 0.0633383474430215 no 312 0.0423597108389072 335 745334
SGTC_1957 st077035 62.4 µM 1.72343367621567 0.0633963356550283 no 313 0.0424050646819474 279 705593
SGTC_1048 3161-0300 24.5 µM 1.72037189650339 0.0637507760418127 no 314 0.0426824310505668 331 2165101
SGTC_1996 st072960 66.8 µM 1.71957076088502 0.0638437717703804 no 315 0.0427552474413121 319 1719405
SGTC_2643 anethole 100 µM 1.71775226404241 0.0640552542195109 no 316 0.0429209059622714 342 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1053 3366-3204 134 µM 1.7175906057043 0.0640740806380525 no 317 0.0429356575242481 351 3632071 YPR165W RHO1
SGTC_1852 st056254 31.4 µM 1.71728642626398 0.0641095164519019 no 318 0.0429634254536937 286 442583
SGTC_2055 5235184 200 µM 1.71495702638221 0.0643813884700983 no 319 0.0431765530369227 339 2836034
SGTC_1150 3909-7983 10.9 µM 1.70859812450342 0.0651281185561484 no 320 0.0437627081576906 359 23965914
SGTC_3054 9094397 49.47 µM 1.70520726814051 0.0655290473826678 no 321 0.0440778874815896 357 2598354
SGTC_482 fipronil 114 µM 1.70246694393037 0.0658544546634309 no 322 0.0443339350234282 211 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1460 k062-0059 9.15 µM 1.70226784275175 0.0658781461917394 no 323 0.0443525850436391 289 1373085
SGTC_516 3992-2719 87.3 µM 1.7015185393379 0.0659673668183479 no 324 0.0444228297736466 286 5350887 YDR037W KRS1
SGTC_3058 9093861 49.47 µM 1.69709949520184 0.0664954543229092 no 325 0.0448389258255027 329 17217477
SGTC_975 1335-0046 28.5 µM 1.69143056519246 0.067177691504881 no 326 0.0453772993718334 364 16486740
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.68808311145583 0.0675830807431765 no 327 0.0456976379534147 334 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1323 1348-1351 11.2 µM 1.68622719464314 0.0678086523350014 no 328 0.0458760239224521 286 6989654
SGTC_2638 epoxomicin 18 µM 1.68541301996178 0.0679077919619845 no 329 0.0459544566857939 342 9915668 A protesome inhibitor.
SGTC_2681 menadione 3.18 µM 1.68025180024234 0.0685388641319555 no 330 0.0464541673453946 338 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2370 9071495 200 µM 1.66719180129718 0.0701559386730625 no 331 0.0477381362383969 348 21791103
SGTC_2869 9037858 32.47 µM 1.66634116514016 0.0702622729047063 no 332 0.0478227410174662 276 27187042
SGTC_9 0092-0002 10.449 µM 1.66440123590229 0.07050523842075 no 333 0.0480161366312368 335 759368
SGTC_2761 levamisole 97.89 µM 1.6626683610138 0.0707228171798146 no 334 0.0481894194011988 321 26879 An alkaline phosphatase inhibitor.
SGTC_957 1187-1561 14.1 µM 1.65982931810701 0.0710804003663681 no 335 0.0484743969708009 370 1538454
SGTC_1665 st014639 11.4 µM 1.65779300938089 0.0713377314588732 no 336 0.0486796264021797 384 981133 YIL048W NEO1
SGTC_774 k060-0086 136 µM 1.6551849773383 0.0716683557189261 no 337 0.048943490787114 387 5911235
SGTC_1310 1188-0297 994 nM 1.64933790320096 0.072413869120622 no 338 0.0495392143062071 355 1588352
SGTC_3333 9141820 12.094 µM 1.64736138826858 0.0726672178362787 no 339 0.0497418933994299 308 1939433
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.64247863740726 0.0732959958018215 no 340 0.0502454249023519 374 688761
SGTC_1831 st055328 12 µM 1.64130879602969 0.0734472587782514 no 341 0.0503666655651337 357 1103068
SGTC_3232 9132874 49.47 µM 1.63889418872658 0.0737602274118434 no 342 0.0506176491078567 333 3784940
SGTC_3198 9112019 49.47 µM 1.63692415968405 0.0740163264256041 no 343 0.0508231585687855 330 45595555
SGTC_1445 4239-0156 97.7 µM 1.63371374343078 0.0744351276279995 no 344 0.0511594856124395 401 4008346
SGTC_701 4424-0219 185 µM 1.62626978474731 0.0754131558098307 no 345 0.051946138256773 377 2911779
SGTC_2955 9076254 12.21 µM 1.62222075968475 0.0759492355505748 no 346 0.0523780441131805 335 16459619
SGTC_2203 7227154 166.4 µM 1.62188474098938 0.0759938535610617 no 347 0.0524140146690553 319 896304
SGTC_916 4466-0038 42 nM 1.62175757460338 0.0760107444664564 no 348 0.0524276328521079 481 5722064 YGL116W CDC20
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.61417702660263 0.0770228048149655 no 349 0.0532445167844964 447 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1656 st012921 11 µM 1.61212128083363 0.0772990198632945 no 350 0.0534677753571989 319 6732821
SGTC_2300 7976697 71.57 µM 1.61196941570496 0.0773194546436482 no 351 0.053484297627424 309 2236109
SGTC_1368 1852-0141 284 µM 1.61064208486262 0.0774982333170098 no 352 0.0536288777438429 375 2838987
SGTC_72 0744-0168 198.391 µM 1.60966082661349 0.077630601032852 no 353 0.0537359606492459 360 677577
SGTC_189 3970-0742 2.116 µM 1.60731431625285 0.0779478316003035 no 354 0.0539927176840324 312 2891807
SGTC_3039 9090270 49.47 µM 1.60493072486865 0.0782710813559295 no 355 0.0542545254925927 320 17173750
SGTC_1613 st002381 52.1 µM 1.60259471665041 0.0785888635137824 no 356 0.054512080483445 372 551167
SGTC_2771 fluoxetine 41.05 µM 1.60159417046762 0.0787252729649703 no 357 0.0546226903773545 331 3386 A selective serotonin reuptake inhibitor.
SGTC_1453 4237-0541 195 µM 1.60071227729289 0.0788456545579691 no 358 0.0547203303168521 355 739892
SGTC_1943 st076331 65.2 µM 1.59935264009066 0.0790315231073776 no 359 0.0548711345961688 353 24208415
SGTC_1361 1608-0041 5.61 µM 1.59881719797478 0.0791048114720625 no 360 0.0549306132796004 376 X1361
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.59367073040088 0.079811858258859 no 361 0.0555049016334906 195 4000243
SGTC_2214 7179297 48.276 µM 1.58791749180663 0.080607913011062 no 362 0.0561524987924851 305 769744
SGTC_1945 st075991 56.6 µM 1.58513435145794 0.0809951516885172 no 363 0.0564679061170601 347 1084980
SGTC_1609 st001574 46.4 µM 1.58178306106261 0.0814633026048477 no 364 0.0568495516212505 377 3960012
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.57017276175164 0.0831009635180084 no 365 0.0581874622801227 402 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3179 9107801 49.47 µM 1.56738304536164 0.0834981240595989 no 366 0.0585125922801882 369 4818259
SGTC_1441 4106-0040 13 µM 1.56734230570608 0.0835039345475544 no 367 0.0585173508660905 363 2904180
SGTC_2865 9030313 51.95 µM 1.56721253038871 0.0835224457606114 no 368 0.0585325112672638 351 42562754
SGTC_2766 oltipraz 83.91 µM 1.56269905718496 0.0841681699983334 no 369 0.0590616981401487 385 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2811 7967822 32.47 µM 1.55664479097008 0.0850402042837117 no 370 0.0597774215987294 413 2232244
SGTC_2673 kobusone 100 µM 1.55060288253734 0.085917192022774 no 371 0.0604984404700669 342 6710676 An epoxy ketone and protein crosslinker.
SGTC_3038 9091290 49.47 µM 1.54793915070296 0.0863059775505915 no 372 0.0608184737221392 392 25236843
SGTC_2713 st079149 53.4 µM 1.54438011811403 0.086827488251998 no 373 0.0612481368316776 413 3103253
SGTC_2738 aclarubicin 5.55 µM 1.54369053568186 0.0869288055970798 no 374 0.0613316600947306 280 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1596 piperlongumine 63 µM 1.54054775105581 0.087391679967411 no 375 0.0617134463142841 420 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.53975631985835 0.087508532688525 no 376 0.0618098814202621 401 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_144 4161-2749 112.381 µM 1.53379403964885 0.08839259816215 no 377 0.0625401648944214 342 797501 YMR168C CEP3
SGTC_1059 3448-6867 171 µM 1.52905741529128 0.0890996582165548 no 378 0.0631251055187007 394 3934407
SGTC_1737 st035557 69.7 µM 1.5289587062312 0.0891144376645629 no 379 0.0631373405759841 342 5716916
SGTC_1444 4112-3581 28 µM 1.52387460992582 0.0898781352532765 no 380 0.0637700185526699 391 2877249
SGTC_623 k072-0108 16.9 µM 1.52348764611875 0.0899364608616958 no 381 0.063818374564402 418 5382803
SGTC_2030 5175110 200 µM 1.52041234995101 0.0904009891325034 no 382 0.0642036862491612 389 2831986
SGTC_47 0149-0135 24.25 µM 1.51753932109324 0.0908365721251922 no 383 0.0645652868265794 377 5239155
SGTC_705 1124-0212 310 µM 1.51741613294882 0.0908552835692821 no 384 0.0645808266340839 427 9554485
SGTC_864 0469-0573 172 µM 1.51715118270697 0.0908955374047166 no 385 0.0646142591401832 394 689425
SGTC_961 1252-1571 372 µM 1.5168252131675 0.0909450800412808 no 386 0.0646554097528648 427 6813498
SGTC_1377 2944-0135 198 µM 1.51534340982434 0.0911705451622858 no 387 0.0648427302177243 444 1894137
SGTC_941 3237-0776 460 µM 1.51455469523815 0.0912907216391538 no 388 0.0649426063457776 380 760008
SGTC_18 0111-0177 500 nM 1.51423251186841 0.0913398465061984 no 389 0.064983439254142 516 721752
SGTC_1213 1315-0166 115 µM 1.51330383658598 0.0914815558005394 no 390 0.0651012493079203 365 768401
SGTC_1349 flufenamic acid 69 µM 1.51207453293234 0.0916693893850828 no 391 0.0652574513664094 378 3371 A non-steroidal anti-inflammatory.
SGTC_2102 5377816 72.7585 µM 1.5112918015567 0.0917891369886694 no 392 0.0653570609187431 429 1379702
SGTC_366 0181-0206 4.31 µM 1.50491547289428 0.0927689510228348 no 393 0.0661729048706799 453 274874
SGTC_1756 st041558 35.5 µM 1.49982457410343 0.0935567766197964 no 394 0.0668299249987003 449 3955792
SGTC_963 1269-2853 151 µM 1.49834209366152 0.0937871193363395 no 395 0.0670221964338099 418 3668223
SGTC_2285 7945142 200 µM 1.49241555630867 0.0947121469846456 no 396 0.0677951196890677 420 2970608
SGTC_1081 sertraline 6 µM 1.49148139377417 0.0948585645994923 no 397 0.0679175763070308 477 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2258 7960471 200 µM 1.47986758416073 0.0966928206090777 no 398 0.0694542940124947 332 2974708
SGTC_2462 5162487 171.77 µM 1.47685416008895 0.0971729821215828 no 399 0.0698573674441251 431 2259986
SGTC_481 bay k-8644 50 µM 1.4756511391573 0.0973651604108575 no 400 0.070018784546116 417 2303 A calcium channel antagonist.
SGTC_3201 9113999 49.47 µM 1.47337099112015 0.0977301706757775 no 401 0.0703255139471257 441 16649224
SGTC_3197 9113331 49.47 µM 1.46990470735597 0.0982869799181725 no 402 0.0707937822406668 465 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_493 zm226600 134 µM 1.46360917251688 0.0993042040586204 no 403 0.0716503824530739 459 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2417 cerulenin 830 nM 1.46062108668898 0.0997896997952974 no 404 0.0720597280723106 388 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_565 1418-0001 44.5 µM 1.45742226854962 0.100311353900996 no 405 0.0724999269014595 477 2862145
SGTC_2395 5646831 180.19 µM 1.45465245320654 0.100764652852182 no 406 0.0728827509041271 444 6808628
SGTC_2096 5468907 200 µM 1.44961369279941 0.101593107190828 no 407 0.0735831377284906 431 759785
SGTC_1435 4092-0789 56.7 µM 1.44934339717227 0.101637687956459 no 408 0.0736208537025321 434 2248285
SGTC_2127 5253358 187.912 µM 1.44548877824613 0.102274993873335 no 409 0.0741603214002839 397 20612
SGTC_3170 9103054 49.47 µM 1.44448190400857 0.102441943828469 no 410 0.0743017331989023 413 16432970
SGTC_1721 st082152 9.2685 µM 1.44401148558769 0.102520011852852 no 411 0.0743678722774071 418 5296051
SGTC_66 0109-0187 42.4 µM 1.44231411724856 0.102802057242926 no 412 0.0746068897020816 434 759417
SGTC_3145 9085516 49.47 µM 1.44204795863066 0.102846334921892 no 413 0.0746444223376316 446 25236195
SGTC_2051 5263410 176 µM 1.43617542738049 0.103826807152625 no 414 0.0754762146717965 460 227584
SGTC_2116 5511452 16.8835 µM 1.4336250279521 0.10425472455905 no 415 0.0758396486624138 485 870744
SGTC_2589 lobaric acid 100 µM 1.43259386970881 0.104428099304554 no 416 0.0759869673414343 456 73157 A novel microtubule depolymerizer.
SGTC_78 0336-0123 156.75 µM 1.43198102946185 0.104531238693126 no 417 0.0760746252737834 408 6765896
SGTC_203 k066-0004 30.888 µM 1.43168723793009 0.104580709189908 no 418 0.076116675190993 559 6795412
SGTC_215 1287-0124 461.5 µM 1.43168450348743 0.104581169712496 no 419 0.0761170666505329 355 5560863
SGTC_2340 7987427 183.45 µM 1.42780815074191 0.105235485601635 no 420 0.0766735430812319 451 2239331
SGTC_423 5-fluorouracil 457 µM 1.42683144271721 0.105400816982064 no 421 0.0768142428563076 473 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_566 0958-0068 16.5 µM 1.42616938563586 0.105512992897871 no 422 0.0769097271287733 405 6815365
SGTC_2453 5731132 22.18 µM 1.42193493015316 0.106232502165629 no 423 0.0775225708630776 493 1362040
SGTC_259 usnic acid 108.925 µM 1.42104701907765 0.106383822454218 no 424 0.0776515453749754 478 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_208 k072-0098 12.366 µM 1.41093150905151 0.10811873253853 no 425 0.0791324051464776 561 5948901
SGTC_1259 0671-0132 43 µM 1.40360696714544 0.109387615354275 no 426 0.0802179596489562 481 X1259
SGTC_666 0272-0154 136 µM 1.40109748585148 0.109824801319683 no 427 0.0805924616670889 514 6870312
SGTC_2755 lomerizine 42.69 µM 1.3984978303252 0.110279017891306 no 428 0.0809818118767499 506 3949 A calcium channel blocker.
SGTC_2046 4110841 106 µM 1.39447940629582 0.110983772413237 no 429 0.0815864420261651 473 44119630 YMR134W ERG29
SGTC_1336 1486-0901 104 µM 1.3940847563435 0.111053160022272 no 430 0.0816460059083704 472 5006114
SGTC_374 0880-0231 82.3 µM 1.39396546665596 0.1110741397256 no 431 0.0816640165600987 493 6833587
SGTC_526 4469-0568 170 µM 1.39256092871158 0.111321371952178 no 432 0.0818763024784755 475 2901964
SGTC_207 4185-0010 4.486 µM 1.39245343912013 0.111340308901989 no 433 0.0818925658812963 567 3761753
SGTC_1118 chelidonine 707.474 nM 1.39200647189548 0.111419077962095 no 434 0.0819602190788128 524 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_710 3448-4187 58 µM 1.39096269534183 0.111603178065429 no 435 0.0821183696485944 594 3946412
SGTC_781 4335-2806 94.4 µM 1.38840420736863 0.112055361536018 no 436 0.0825069979645227 546 845254
SGTC_505 gw-5074 63.9 µM 1.38831922051225 0.112070404434355 no 437 0.0825199309874396 493 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2715 st079500 56.4 µM 1.38636536534003 0.112416640159578 no 438 0.082817683309309 447 28246688
SGTC_804 1595-0054 20.9 µM 1.38570191180116 0.112534382031314 no 439 0.0829189720935709 474 761523 Stimulates phospholipase C.
SGTC_1994 st072947 40.9 µM 1.38019621315029 0.113514867729293 no 440 0.0837631198261054 495 5286565 YDL195W SEC31
SGTC_2752 diclazuril 33.15 µM 1.3751970685197 0.114410406569101 no 441 0.0845351784522599 676 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_836 0330-0104 1.35 µM 1.37236502026924 0.114919961397594 no 442 0.0849749168839023 485 46494820
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.3723448717146 0.114923592389609 no 443 0.0849780515259032 479 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_777 1315-0167 517 µM 1.36918936904421 0.115493256269031 no 444 0.0854700441228946 475 4221767
SGTC_3220 9131269 49.47 µM 1.36855156494542 0.115608642583815 no 445 0.0855697464965731 462 17722206
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.3684506821333 0.115626900977853 no 446 0.0855855246039757 464 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_575 k072-0246 11.9 µM 1.36458950345302 0.11632726109236 no 447 0.0861910528415466 520 6796779
SGTC_652 0437-0092 114 µM 1.36054462094838 0.117064164713704 no 448 0.0868288213214062 470 3091274
SGTC_3222 9128301 49.47 µM 1.35995416274865 0.117172011448191 no 449 0.0869222147626313 499 4911358
SGTC_2680 butyl paraben 22.24 µM 1.35856618271123 0.117425802073709 no 450 0.0871420486458691 446 7184 An antifungal and steroid mimetic.
SGTC_1802 st050112 57.9 µM 1.35499605055692 0.118080384361874 no 451 0.0877094076719074 513 4662563
SGTC_257 daunorubicin 18.5 µM 1.35168057203028 0.118690583427164 no 452 0.088238761356503 455 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1163 k060-0048 49.9 µM 1.35036238251709 0.118933808233459 no 453 0.088449885539151 556 6809982
SGTC_1855 st056195 39.6 µM 1.34874826207795 0.119232115638622 no 454 0.0887089189983752 503 4028379
SGTC_3123 9126162 49.47 µM 1.34832516117842 0.119310396671416 no 455 0.0887769114385692 499 25239884
SGTC_2241 6772625 37.8075 µM 1.34746774096817 0.119469145550312 no 456 0.0889148181146135 494 2285411
SGTC_2734 clemastine 41.6 µM 1.3455602098348 0.119822853843271 no 457 0.0892221956446713 349 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1724 st037281 8.293 µM 1.34542117177215 0.119848664132126 no 458 0.0892446309667535 538 574124 YDL195W SEC31
SGTC_1279 0874-0590 65.2 µM 1.34410751715217 0.120092717494048 no 459 0.0894568108184461 527 3523074
SGTC_143 4032-1194 15.74 µM 1.34187417823823 0.120508435084701 no 460 0.0898183977332043 615 1806963
SGTC_1358 1509-0022 2.48 µM 1.33926672967401 0.120995071081878 no 461 0.0902419278316125 529 3258434
SGTC_2077 5212015 200 µM 1.3373331089939 0.121356840272145 no 462 0.0905569641023675 511 780900
SGTC_2511 berberine 10.47 µM 1.33285102951182 0.122198334132262 no 463 0.0912903478483874 505 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2833 9001315 45.46 µM 1.33191502357226 0.122374581624378 no 464 0.0914440568250342 555 2989378
SGTC_300 r073-0011 5.04 µM 1.32983426034023 0.122767022886427 no 465 0.0917864425641043 593 2735780
SGTC_2725 haloperidol 53.21 µM 1.32831667740156 0.123053801899402 no 466 0.0920367562601882 524 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1591 genipin 88.4 µM 1.32742092260747 0.123223293713672 no 467 0.0921847411874136 478 442424 A DNA cross-linking agent.
SGTC_3181 9108277 49.47 µM 1.32266181562935 0.124126539906087 no 468 0.0929739336197242 507 17097298
SGTC_1610 st001799 48.1 µM 1.32249187350754 0.12415887920244 no 469 0.0930022068274274 454 621897
SGTC_878 0828-0289 13.7 µM 1.32098509736266 0.124445870420083 no 470 0.0932531666531836 589 745350 YLR208W SEC13
SGTC_1169 aniline yellow 25.8 µM 1.32073124486066 0.124494266578284 no 471 0.0932954960460783 490 6051 A DNA damaging agent.
SGTC_2383 9036125 200 µM 1.31952018040677 0.124725333229521 no 472 0.0934976340252526 480 79580
SGTC_287 k060-0039 29.6 µM 1.31799282764457 0.125017173665012 no 473 0.0937530244560088 515 5861974
SGTC_1274 0865-0114 173 µM 1.31602601909144 0.125393685668474 no 474 0.0940826548995379 530 870624
SGTC_677 0929-0063 136 µM 1.31271899226906 0.126028542527672 no 475 0.0946388277233989 457 1539583
SGTC_165 k038-0023 64.381 µM 1.31163413417435 0.126237292332644 no 476 0.0948218050606106 581 46368543
SGTC_3184 9108758 49.47 µM 1.30964524401868 0.126620622778992 no 477 0.0951579375645539 512 902885
SGTC_704 1310-0270 142 µM 1.30848689357419 0.126844251652451 no 478 0.0953541085712348 563 5718033
SGTC_2992 9074591 71.4286 µM 1.30541342880519 0.127438940925543 no 479 0.0958760540716209 529 17741321
SGTC_593 1203-0218 61.7 µM 1.3044087783482 0.127633752059109 no 480 0.0960471218697535 562 3666956
SGTC_3226 9131256 49.47 µM 1.3016582005564 0.128168173837823 no 481 0.0965166272810226 394 17178073
SGTC_1729 st035615 45.989 µM 1.30141291705383 0.128215906404072 no 482 0.0965585772946615 537 17385451
SGTC_883 0850-0245 24.6 µM 1.30069722913783 0.128355250984837 no 483 0.0966810555528909 585 6823229 YPR165W RHO1
SGTC_612 0302-0167 22.4 µM 1.30014157115848 0.128463510184541 no 484 0.0967762259679656 617 235821
SGTC_315 k915-0449 187 µM 1.29989318130511 0.128511924631948 no 485 0.0968187912259636 635 20970215 YNL149C PGA2
SGTC_559 1550-0661 158 µM 1.29978365937258 0.1285332759188 no 486 0.0968375637879304 537 5830875
SGTC_2118 5526350 200 µM 1.29838057306638 0.128807025236166 no 487 0.0970782957068049 551 743594
SGTC_697 0508-1955 564 µM 1.29790586728299 0.128899734264339 no 488 0.0971598418286115 596 6243113
SGTC_2918 7977171 22.06 µM 1.29662005201437 0.12915108366995 no 489 0.0973809747924752 509 2236483
SGTC_1473 k844-0725 134 µM 1.29561929868213 0.129346944555998 no 490 0.0975533384816422 616 54682906
SGTC_424 splitomicin 100 mM 1.29530810075253 0.129407892112438 no 491 0.0976069829045388 519 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_648 0375-0473 33.3 µM 1.29359404990739 0.129743942542948 no 492 0.0979028393986628 588 1713139
SGTC_2942 9052777 62.25 µM 1.28836775167239 0.130772319723322 no 493 0.0988089894341167 612 6469503
SGTC_1494 4358-1428 177 µM 1.28816955995724 0.130811428420484 no 494 0.0988434728401454 573 1564571
SGTC_1413 3910-0535 34.4 µM 1.28810420128442 0.130824327263382 no 495 0.0988548465359083 562 2876951
SGTC_1437 4092-1038 11.6 µM 1.28711635730034 0.131019389996749 no 496 0.0990268674653658 580 3977136
SGTC_2032 5185112 25.99 µM 1.28577804376972 0.131283977923374 no 497 0.0992602674973393 506 5718189
SGTC_2687 chenodiol 100 µM 1.28055779683445 0.132319559215756 no 498 0.100174515827353 529 5702181 A cholesterol synthesis inhibitor.
SGTC_2920 7982904 15.77 µM 1.27999487392839 0.132431566028203 no 499 0.100273469363919 485 6456808
SGTC_2729 fluphenazine 10.66 µM 1.27994372316028 0.132441746919297 no 500 0.100282464448526 558 3372 An atypical antipsychotic.
SGTC_2740 felodipine 17.08 µM 1.27672829733897 0.133082818145397 no 501 0.100849093771538 476 3333 L-type calcium channel blocker
SGTC_1793 st048256 72.231 µM 1.27446411104115 0.13353551674457 no 502 0.101249491944999 536 672022
SGTC_297 0986-0032 24 µM 1.27429720100335 0.133568930392223 no 503 0.101279054053136 523 2847425
SGTC_2965 9082772 38.63 µM 1.27411204190748 0.133606004037206 no 504 0.101311855682577 597 16459634
SGTC_183 3914-0051 30.55 µM 1.27171153320219 0.134087288591715 no 505 0.101737815646603 561 1596232
SGTC_363 0455-0021 3.06 µM 1.26848135867419 0.134736792836134 no 506 0.102313051818707 593 4597466
SGTC_2294 7971431 200 µM 1.26790206997381 0.134853500670109 no 507 0.102416462404654 496 5741572
SGTC_1519 esterone 74 µM 1.26726314164218 0.134982304359978 no 508 0.102530607560673 575 698 A steroid.
SGTC_2690 usnic acid 100 µM 1.26703436686056 0.135028444339218 no 509 0.102571500872254 647 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_929 2805-0021 398 µM 1.26694141006523 0.135047195232609 no 510 0.102588120213146 548 3098024
SGTC_2139 5578692 56.4705 µM 1.2657599697945 0.135285666477634 no 511 0.102799515337284 506 650991 YMR113W FOL3
SGTC_2993 9054257 71.4286 µM 1.26553946835647 0.135330206177184 no 512 0.102839004689795 591 6470217 YGL055W OLE1
SGTC_3304 9125678 46.087 µM 1.26431880353861 0.135576953488122 no 513 0.103057811581227 598 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3182 9108849 49.47 µM 1.26373610359717 0.135694850092021 no 514 0.103162381000197 589 17133045
SGTC_1983 st071813 46.9 µM 1.26334492786831 0.135774035340075 no 515 0.103232623324987 570 11838595
SGTC_2188 6126565 140.678 µM 1.25947156519284 0.13655982382959 no 516 0.103930027256255 515 874518
SGTC_942 3253-1115 227 µM 1.25674098086269 0.137115642610377 no 517 0.104423721732329 571 46497897
SGTC_1415 3966-0071 78.1 µM 1.25628086549497 0.137209452440117 no 518 0.10450707842311 561 2893185
SGTC_1623 st003709 20.3 µM 1.25045659695246 0.138400713428736 no 519 0.105566400448731 660 16192618
SGTC_1094 duloxetine 25.4 µM 1.2452101628576 0.139479805482947 no 520 0.106527253935766 580 60834 A selective serotonin reuptake inhibitor.
SGTC_2586 curcumin 80 µM 1.24443020631225 0.139640715059091 no 521 0.106670635741415 683 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_430 0958-0115 16.4 µM 1.24125893513101 0.140296266424767 no 522 0.107255054729875 576 6833180
SGTC_2187 6125751 200 µM 1.24101667714748 0.14034643072919 no 523 0.107299794067331 598 874498
SGTC_384 k007-0144 5.16 µM 1.23948379342016 0.140664126961504 no 524 0.107583193471815 646 6824886
SGTC_3241 9133421 49.47 µM 1.23924408723497 0.140713851113279 no 525 0.107627559050982 532 17018221
SGTC_1947 st076332 61.6 µM 1.23912037557714 0.140739518267941 no 526 0.107650461152679 517 24208416
SGTC_499 genistein 192 µM 1.23681766842473 0.141217853842719 no 527 0.108077390555804 532 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1263 0774-1208 64.8 µM 1.235095671247 0.141576279495165 no 528 0.108397450125306 676 906585
SGTC_1838 st055369 84.5 µM 1.23459020822103 0.141681606168441 no 529 0.108491527522865 547 676036
SGTC_2488 5268135 45.7 µM 1.22950268523356 0.142744682544703 no 530 0.109441695844988 691 1270356 YLR208W SEC13
SGTC_1138 3761-0006 1.03 µM 1.22891604812839 0.142867610641186 no 531 0.109551641923443 566 12061087
SGTC_3354 9151612 71.43 µM 1.22864582511452 0.142924259149189 no 532 0.109602313126825 642 27261949
SGTC_1320 1313-0481 95.3 µM 1.22672622883822 0.143327112787092 no 533 0.109962753024833 609 6813365 YLR208W SEC13
SGTC_971 1315-0384 26.7 µM 1.22326804862858 0.144054792721697 no 534 0.110614235501969 595 6769120
SGTC_3031 9088762 49.47 µM 1.22274096357301 0.144165921850782 no 535 0.110713774886755 618 205253
SGTC_308 4092-1169 104 µM 1.22191548148091 0.144340080288983 no 536 0.110869795152705 642 2268590 YDL196W YDL196W
SGTC_16 erodoxin 22.806 µM 1.22190875409088 0.144341500201561 no 537 0.110871067309995 662 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1299 1079-1439 3.74 µM 1.22187509909587 0.144348603714434 no 538 0.110877431665763 577 323161
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.22182573059095 0.144359024282238 no 539 0.110886768011409 606 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_797 k781-0471 270 µM 1.220793440818 0.144577033298792 no 540 0.111082118950932 623 23738129
SGTC_350 k064-0020 19.8 µM 1.21783563089091 0.14520292016749 no 541 0.111643220587528 653 2790705
SGTC_1458 k015-0034 6.33 µM 1.21776342853104 0.145218221297578 no 542 0.111656942806614 566 3598957
SGTC_955 1216-0110 33 µM 1.2158853538288 0.145616604194817 no 543 0.112014299053437 647 3619719
SGTC_647 0140-0236 81 µM 1.21578138803895 0.145638679177964 no 544 0.112034105311972 689 990837
SGTC_469 w7 172 µM 1.21395224755228 0.146027427316713 no 545 0.112382979825249 559 45115570 A P450 inhibitor.
SGTC_3141 9094609 49.47 µM 1.21387554943344 0.146043743221136 no 546 0.112397625501747 569 25236309 YDL196W YDL196W
SGTC_75 0159-0059 199.013 µM 1.21146733179791 0.146556663619577 no 547 0.112858173808851 592 5377270
SGTC_1487 3970-0795 2.82 µM 1.21141611099267 0.146567586129249 no 548 0.11286798390178 649 3765103
SGTC_3009 9080819 71.4286 µM 1.20354024522329 0.148253566183843 no 549 0.114383663613363 618 17027216
SGTC_3015 9080845 49.47 µM 1.19944990451012 0.149134281160976 no 550 0.115176526354129 652 5296973
SGTC_1079 idarubicin 2.36 µM 1.19831153791581 0.149380009781165 no 551 0.115397878244755 608 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1730 st033808 45.1 µM 1.19816941796047 0.149410706863351 no 552 0.11542553424752 700 1045166
SGTC_890 0929-0006 47.2 µM 1.19543993980036 0.15000107526011 no 553 0.115957594426364 594 1378169
SGTC_2850 9015429 58.44 µM 1.195171959279 0.150059121443102 no 554 0.116009925880507 574 6457570
SGTC_2393 9031399 185.94 µM 1.19179932003253 0.15079093543295 no 555 0.116669971239191 610 1526623 YDL150W RPC53
SGTC_2675 theaflavin digallate 100 µM 1.1913253755814 0.150893964622432 no 556 0.116762937921989 648 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.19024404052369 0.15112920778847 no 557 0.116975244021292 640 4213774
SGTC_2931 9014674 55.67 µM 1.18600401691095 0.152053973026764 no 558 0.117810356598351 599 2996810
SGTC_1567 st069303 68.4 µM 1.1855950726676 0.152143363614941 no 559 0.117891124530857 652 5581319
SGTC_2253 7938677 135.83 µM 1.1855200996503 0.152159755653387 no 560 0.117905936215191 614 2301972
SGTC_3046 9092212 49.47 µM 1.1850667198421 0.152258907226953 no 561 0.117995534075531 615 25236637
SGTC_114 0364-0001 490.298 µM 1.18406575016314 0.152477965434764 no 562 0.118193518307139 640 4003655
SGTC_813 k007-0158 173 µM 1.18252294650949 0.152816011249379 no 563 0.118499133063795 708 6523916
SGTC_463 ikarugamyin 104 µM 1.18219418965127 0.15288810980339 no 564 0.118564328796768 566 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2400 5203494 178.7 µM 1.18178918657543 0.152976960661236 no 565 0.11864467975002 591 6777674
SGTC_2957 9076800 11.52 µM 1.18151580472628 0.153036955386276 no 566 0.118698939336739 573 16459615
SGTC_342 k048-0088 23.3 µM 1.17910070689609 0.153567635570177 no 567 0.119179038583988 622 6820570
SGTC_1478 0453-0656 35.7 µM 1.17806314638277 0.153795997136666 no 568 0.119385716450736 634 5258496
SGTC_954 1189-0853 2.85 µM 1.17780628332389 0.153852566027372 no 569 0.119436921567799 662 2828194
SGTC_2881 9058953 51.95 µM 1.17565042868404 0.154327892155564 no 570 0.119867297564659 661 17122249
SGTC_3190 9110366 49.47 µM 1.17401077425145 0.154690055103598 no 571 0.120195355040775 543 17123768
SGTC_1767 st044992 70.3 µM 1.16798329059085 0.156026214336178 no 572 0.121406752507115 631 9600693
SGTC_842 0271-0008 11.1 µM 1.16770624681751 0.156087811085473 no 573 0.121462638081528 700 1221709
SGTC_824 1304-0008 100 µM 1.1671254269213 0.156217000149838 no 574 0.121579860403943 678 768245
SGTC_534 k292-0788 63.4 µM 1.16676870060547 0.156296380031777 no 575 0.121651895079594 719 4146317
SGTC_31 0508-1974 57.237 µM 1.16122669283798 0.157533017667726 no 576 0.122774861136564 640 6810525
SGTC_622 1348-1566 26.3 µM 1.16102766742414 0.15757754725487 no 577 0.122815324049615 712 7340407
SGTC_1455 4262-0120 131 µM 1.16075322620367 0.157638963802461 no 578 0.122871134730127 675 1529587
SGTC_1829 berberine 14.4 µM 1.16056050082125 0.157682102755594 no 579 0.122910338212408 635 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_138 0850-0259 40.9225 µM 1.16024327147689 0.15775312711262 no 580 0.122974886926478 768 6813004
SGTC_484 loperamide 105 µM 1.16003026067863 0.157800829809296 no 581 0.123018242951103 540 3955 An opioid-receptor agonist.
SGTC_2173 5763948 167 µM 1.15485009256227 0.158963818753833 no 582 0.124075909884358 677 2867177
SGTC_262 fenpropimorph 62.5 µM 1.15210214322512 0.159583029452573 no 583 0.124639551271247 609 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1335 1486-0900 202 µM 1.15178594166616 0.159654382047685 no 584 0.124704523100818 678 X1335
SGTC_1044 1222-0021 1.78 µM 1.14805478850327 0.160497913339517 no 585 0.125472973374001 666 4306703
SGTC_3332 9141069 11.198 µM 1.14497098458958 0.161197286979874 no 586 0.12611058849504 593 17332883
SGTC_2165 5727197 32.143 µM 1.14169022606784 0.161943507267638 no 587 0.126791402466587 632 1361712
SGTC_1564 D-Arginine 115 µM 1.14086394909278 0.162131801118532 no 588 0.126963271854939 652 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_294 k038-0071 157 µM 1.14078112092659 0.162150684045744 no 589 0.126980509430274 680 24152826
SGTC_3320 9137005 35.139 µM 1.14003970171706 0.162319774445487 no 590 0.127134880573009 634 4908713
SGTC_1149 3909-7961 23.3 µM 1.13744624464343 0.162912149055543 no 591 0.127675892222899 660 735261
SGTC_2135 5326629 150.42 µM 1.13577168845684 0.163295382271231 no 592 0.128026064402555 609 5020077
SGTC_2872 9044037 25.97 µM 1.1353444020166 0.163393263305901 no 593 0.128115522474043 623 6465195
SGTC_403 arphamenine a 50 µM 1.13368007774508 0.163774883167364 no 594 0.128464384661483 656 5487158 An arginine aminopeptidase inhibitor.
SGTC_1232 0279-0259 161 µM 1.13249693835484 0.164046521665447 no 595 0.128712785415267 683 1560000
SGTC_1644 st010134 20.9 µM 1.13038023035224 0.164533228154936 no 596 0.129158020407772 647 3818134
SGTC_848 0368-0089 85.6 µM 1.12836470939236 0.164997537050719 no 597 0.129582962713048 704 762535
SGTC_921 1561-0023 372 µM 1.12284837771164 0.166272650108229 no 598 0.13075094748739 691 24050882
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.12282439821435 0.166278206881912 no 599 0.13075604055272 737 165506
SGTC_2718 lomofungin 53.02 µM 1.1214492391163 0.166597073421083 no 600 0.13104834347757 664 5351222 A RNA synthesis inhibitor.
SGTC_1520 flindersine 88 µM 1.12081518880827 0.16674422738547 no 601 0.131183268745193 708 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_13 0199-0087 65 µM 1.11889772499807 0.16718975332294 no 602 0.131591886822439 702 4589825
SGTC_1272 0839-0021 27 µM 1.11889344609371 0.167190748390933 no 603 0.131592799652807 713 5027250
SGTC_343 4130-2827 29.8 µM 1.11730976285086 0.16755929937174 no 604 0.131930951306157 714 1118244
SGTC_2911 7942208 15.64 µM 1.11548998085249 0.167983440371469 no 605 0.132320254771336 650 1243384
SGTC_2315 7733312 200 µM 1.11359790273862 0.168425163674207 no 606 0.132725863283637 641 726316
SGTC_2741 miltefosine 3.04 µM 1.11237287148115 0.16871155664806 no 607 0.132988931896804 595 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_847 0342-0274 5.54 µM 1.1119927309059 0.16880049110638 no 608 0.133070637885134 717 18097
SGTC_2317 5986382 200 µM 1.10940474596362 0.169406754510161 no 609 0.133627807955179 726 877883
SGTC_564 3555-0129 330 µM 1.10929897950226 0.169431561131462 no 610 0.133650612598234 608 563260
SGTC_693 4161-2696 114 µM 1.10926924863047 0.169438534673546 no 611 0.133657023447828 644 805759
SGTC_2688 kanamycin b 96.69 µM 1.10860097917334 0.169595329605944 no 612 0.133801177768747 1113 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_405 ebelactone b 50 µM 1.10611992683912 0.170178268713769 no 613 0.134337307418589 725 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2593 nobiletin 86.24 µM 1.10344137492996 0.170809051109576 no 614 0.134917768632831 637 72344 An anti-infammatory.
SGTC_726 3448-4391 34.2 µM 1.10278335392777 0.17096423962674 no 615 0.13506062931081 759 1356692
SGTC_1195 1502-0147 41.1 µM 1.1017180891781 0.171215664181846 no 616 0.135292125124249 728 817940
SGTC_2515 chrysin 20.77 µM 1.10171138235631 0.171217247879341 no 617 0.135293583464497 711 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1893 st059353 36.1 µM 1.10034739104999 0.171539524983114 no 618 0.135590395509326 696 3112488
SGTC_748 act1.228 77.9 µM 1.10026043426845 0.171560083835558 no 619 0.135609332900715 724 4421505 YNR035C ARC35
SGTC_187 1488-2104 32.728 µM 1.09949926316348 0.171740111752568 no 620 0.135775177600321 731 2852859
SGTC_357 1325-0123 420 µM 1.09851101790836 0.171974025934937 no 621 0.135990704607852 681 1098503
SGTC_3089 9117425 49.47 µM 1.09679531873651 0.172380608753748 no 622 0.136365438521257 642 9401657
SGTC_2489 cantharidin 73.42 µM 1.09572343030087 0.172634933596055 no 623 0.13659991292591 708 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1579 chlormadinone acetate 49.4 µM 1.09479112905248 0.172856333288741 no 624 0.136804076847834 728 45114258 A steroidal progestin.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.09394052327858 0.173058490007812 no 625 0.136990532228155 773 66535 A nucleotide analog.
SGTC_1886 st057356 49.9 µM 1.09154025504436 0.173629754416342 no 626 0.137517614425557 674 24207747
SGTC_905 2-aminofluorene 215 µM 1.08945327516115 0.174127430117836 no 627 0.137977024478009 775 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3066 9117245 49.47 µM 1.08941418836193 0.174136759668647 no 628 0.137985638689454 744 17176980
SGTC_1031 k035-0009 16 µM 1.08755894807018 0.174579948705341 no 629 0.13839493095752 778 5180959
SGTC_990 3985-0011 41.3 µM 1.08642001509469 0.174852377200111 no 630 0.138646605190949 656 5399565 YGL099W LSG1
SGTC_55 0767-0285 6.563 µM 1.08564319514534 0.175038344304319 no 631 0.1388184407119 747 3116166
SGTC_1804 st050076 49.1 µM 1.08501578150186 0.175188635797003 no 632 0.138957332824329 727 3895976
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.08350431669634 0.17555103002483 no 633 0.139292317935294 691 641818 YHR062C RPP1
SGTC_1929 genistein trimethyl ether 50.5 µM 1.0809781034887 0.176157783733048 no 634 0.139853426944247 718 136420
SGTC_459 nigericin 15.3 µM 1.08048922897132 0.176275356242712 no 635 0.13996219032303 745 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3283 9109332 35.8195 µM 1.07604158687976 0.177347277621087 no 636 0.140954328931259 628 17027281
SGTC_595 3909-8003 73.7 µM 1.07094637903768 0.178580314805143 no 637 0.142096770186918 723 699517
SGTC_1573 oleylamine 1.06 µM 1.06681550586207 0.179583936632936 no 638 0.143027577622547 725 5356789 An amine of the fatty acid oleic acid.
SGTC_1495 4469-0029 237 µM 1.06599759912149 0.179783071873684 no 639 0.143212363608742 838 793680
SGTC_1704 st028805 70.8 µM 1.06343644222285 0.180407531953084 no 640 0.143792036918136 711 2876101
SGTC_3103 9120822 49.47 µM 1.0593956937677 0.181395508624296 no 641 0.14470980500792 770 17141819
SGTC_3208 9114115 49.47 µM 1.05896408008823 0.181501239500912 no 642 0.144808069366069 651 650895
SGTC_332 4112-0506 40.9 µM 1.05846898030788 0.181622569836341 no 643 0.144920842759915 746 2790355
SGTC_3132 9126706 49.47 µM 1.05378841262144 0.182772107702323 no 644 0.145989899879656 718 850858
SGTC_1383 3049-0032 20.7 µM 1.05171166029695 0.183283605329148 no 645 0.14646592981262 755 712864
SGTC_1020 4335-0961 93.3 µM 1.05140336270139 0.183359614087468 no 646 0.146536686029451 707 669075
SGTC_607 4491-0986 66.8 µM 1.05123859674263 0.183400244115503 no 647 0.146574510248041 779 698981 YDR232W HEM1
SGTC_396 dithiazanine 1.25 µM 1.05014177121821 0.183670855943738 no 648 0.146826468130475 706 10578 An antihelmenthic.
SGTC_77 0828-0286 12.516 µM 1.0484766353951 0.18408215812968 no 649 0.147209530779746 755 745345
SGTC_2536 dehydroabietamide 32.04 µM 1.04640253205283 0.184595279856558 no 650 0.147687612106894 802 3983547
SGTC_387 norethindrone acetate 66.7 µM 1.04529020131734 0.184870830390593 no 651 0.147944432508681 711 541197
SGTC_2802 7925815 54.55 µM 1.04469950278836 0.185017264201582 no 652 0.148080937356852 749 1262923
SGTC_2384 9036245 200 µM 1.04239261687105 0.185589829806764 no 653 0.148614844056172 790 6462766
SGTC_688 0527-0193 473 µM 1.04176750798095 0.185745170029815 no 654 0.148759740875554 739 4007154
SGTC_818 4072-2707 53.5 µM 1.04043568505665 0.186076398319831 no 655 0.149068764926426 739 882871
SGTC_2514 salinomycin 42.74 µM 1.03935948146104 0.186344320628015 no 656 0.149318790427501 852 23682228 A polyether potassium ionophore.
SGTC_3115 9123671 49.47 µM 1.03827857831114 0.186613653328868 no 657 0.149570189398432 801 3286988
SGTC_43 0570-0105 72.5 µM 1.036820159319 0.186977434858994 no 658 0.149909839295667 849 1114046 YDL195W SEC31
SGTC_2484 5809818 12.04 µM 1.0362611723273 0.187116982311961 no 659 0.150040157527203 733 2870548
SGTC_1461 k072-0203 53.8 µM 1.03450867572843 0.187554899046423 no 660 0.150449211530095 725 5418714
SGTC_1043 0916-0009 19.3 µM 1.02723180062923 0.189380021994657 no 661 0.152155663607489 891 3101130
SGTC_347 4534-1311 26.2 µM 1.02679680341969 0.189489469399441 no 662 0.152258077451119 769 2862016
SGTC_2208 7283366 200 µM 1.02525899687039 0.18987670089876 no 663 0.152620498700468 794 898663
SGTC_248 streptozotocin 5.23457 mM 1.02516849453988 0.189899505229742 no 664 0.152641845577551 820 5300 DNA alkylating agent.
SGTC_1330 1469-0054 61.8 µM 1.02449819756308 0.190068455770813 no 665 0.152800010869423 828 7102664
SGTC_997 3996-0078 137 µM 1.02142581730142 0.190844040740986 no 666 0.153526369388193 790 735687
SGTC_854 0422-0053 192 µM 1.01963254032877 0.191297627787244 no 667 0.153951383131693 762 3596728
SGTC_3092 9117248 49.47 µM 1.01840808655465 0.19160771739632 no 668 0.154242030399686 846 17141857
SGTC_3185 9108267 49.47 µM 1.01796019189868 0.191721222373081 no 669 0.154348437260721 763 4910486
SGTC_2442 5158906 48.48 µM 1.0159532015195 0.192230337132871 no 670 0.154825836235407 791 1893835
SGTC_2251 lansoprazole 556 µM 1.01487492903685 0.192504204503398 no 671 0.155082725237385 632 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1611 st001856 99.4 µM 1.01483752176532 0.192513709749194 no 672 0.155091642241237 764 647478
SGTC_2475 5812728 15.03 µM 1.01122333298203 0.193433433291679 no 673 0.155954775302831 825 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2486 5283202 22.39 µM 1.00822263694024 0.194199070840708 no 674 0.156673796454609 742 1377751
SGTC_2220 6782180 200 µM 1.00717320128837 0.194467272868145 no 675 0.15692577444492 699 833803
SGTC_1148 3909-7663 27.7 µM 1.00303677140569 0.195526605342333 no 676 0.15792155987717 819 4084526
SGTC_2061 5245884 80.95 µM 1.00272095092487 0.195607630154004 no 677 0.157997759187755 803 573863
SGTC_589 1227-0070 34.1 µM 1.00234035604459 0.195705300138896 no 678 0.158089618952172 800 2841384
SGTC_1183 1254-0324 198 µM 1.00111266719747 0.196020556928407 no 679 0.158386170826808 811 5799357
SGTC_835 0312-0010 67.2 µM 1.00078029738963 0.19610595874493 no 680 0.158466518470373 760 1626196
SGTC_2751 anetholtrithion 17.25 µM 1.00043513200236 0.196194672244204 no 681 0.158549987632936 779 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_970 1315-0089 19.5 µM 0.998729957581369 0.196633288632849 no 682 0.158962762165937 754 6811083 YLR033W RSC58
SGTC_2117 5521686 200 µM 0.996618089916765 0.197177340052904 no 683 0.159474960909713 778 803312
SGTC_2122 5258151 111.688 µM 0.995596238125111 0.197440912317826 no 684 0.159723181658829 794 2173356
SGTC_2328 6201408 200 µM 0.993320507280053 0.198028670086821 no 685 0.160276893421442 770 2890418
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.992329862112574 0.198284855837815 no 686 0.16051832037503 838 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1311 1190-0148 100 µM 0.988729051610952 0.199217726906616 no 687 0.161397862441133 936 1961333
SGTC_2797 7859098 81.82 µM 0.988106601769141 0.199379254112727 no 688 0.161550221446902 803 972681
SGTC_117 lucigenin 22.078 µM 0.983279057204228 0.200634688605916 no 689 0.162735057281639 844 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3135 9127742 49.47 µM 0.983235538137627 0.200646027565677 no 690 0.162745763911522 755 3643468
SGTC_3065 9113888 49.47 µM 0.983037518124457 0.200697626842653 no 691 0.162794486894693 764 16648368
SGTC_2846 9008642 19.48 µM 0.981483357290749 0.201102880494275 no 692 0.163177218778471 749 2992898
SGTC_270 tamoxifen 5.46 µM 0.977082053862388 0.202253197867496 no 693 0.164264265789642 884 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.976898287382287 0.202301312214836 no 694 0.164309754873942 795 279621
SGTC_2859 9028643 45.46 µM 0.974820759457263 0.202845733490355 no 695 0.164824588875575 799 17151580
SGTC_314 1671-0008 2.74 µM 0.972989332038302 0.203326388616169 no 696 0.165279302076547 859 3913060
SGTC_1405 3909-7894 12 µM 0.97265688250612 0.203413712277433 no 697 0.165361930781124 838 7104060
SGTC_2382 9035899 200 µM 0.972082520785598 0.2035646310994 no 698 0.165504748542374 842 6462679
SGTC_731 3966-0296 387 µM 0.971361573803354 0.203754161036251 no 699 0.16568412831586 829 660956
SGTC_1224 0823-0416 294 µM 0.97095691901216 0.20386058691576 no 700 0.165784866071535 842 3598164
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.969590806536919 0.204220124781376 no 701 0.166125248628869 850 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1770 st043884 66.3 µM 0.969311857588139 0.204293585858688 no 702 0.166194807419947 839 670149
SGTC_1050 3232-1156 69.3 µM 0.968576079322375 0.20448742819453 no 703 0.166378371545116 800 700529
SGTC_3072 9116419 49.47 µM 0.967962180973828 0.204649244744534 no 704 0.166531628854568 743 17170162
SGTC_2858 9025781 8.96 µM 0.967927322510895 0.204658435319863 no 705 0.166540333866049 929 4894980 YPL153C RAD53
SGTC_1931 st074438 57.1 µM 0.966793155027064 0.204957597126227 no 706 0.166823723490023 808 2787313
SGTC_1985 st071382 65.5 µM 0.964114675832832 0.205665136540159 no 707 0.167494217831003 847 6123237
SGTC_2979 9012552 45.46 µM 0.96348913556986 0.205830586053133 no 708 0.167651056878766 795 17100905
SGTC_2733 amorolfine 100 µM 0.960308548500445 0.20667304215389 no 709 0.168449974482246 791 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1061 3448-9325 110 µM 0.958463446807237 0.207162696794622 no 710 0.168914557553529 835 723482
SGTC_3166 9102297 49.47 µM 0.955135286500458 0.208047659958009 no 711 0.169754643231021 836 25237072
SGTC_3258 9138477 49.47 µM 0.954996652460663 0.208084571319557 no 712 0.169789694913608 848 4970355
SGTC_2595 hexamethylquercetagetin 100 µM 0.953295078072141 0.20853793087712 no 713 0.170220292294412 783 386331
SGTC_3207 9114163 49.47 µM 0.95321706361319 0.208558730639681 no 714 0.170240051254803 897 849233
SGTC_1126 isoteolin 1.0172 µM 0.951841843160566 0.208925584717262 no 715 0.170588598785058 818 133323
SGTC_1612 st002233 45.4 µM 0.94969052521862 0.209500232534671 no 716 0.171134762737215 842 1035021
SGTC_1968 st069590 43.6 µM 0.949406844675283 0.209576076996746 no 717 0.171206865248305 831 6384066
SGTC_2265 7929201 200 µM 0.949390347758656 0.209580488087822 no 718 0.171211058833872 901 1265108
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.947256841766349 0.210151423817057 no 719 0.171753958506989 880 23847180
SGTC_782 0083-0095 30.5 µM 0.946249078260232 0.210421423210628 no 720 0.172010779593986 898 3591729 An indicator and reagent.
SGTC_2878 9043973 25.97 µM 0.945990443033467 0.210490749428053 no 721 0.172076730383064 831 6465167
SGTC_3200 9114385 49.47 µM 0.945869659505131 0.210523129598358 no 722 0.172107535153342 795 17018030 YLR208W SEC13
SGTC_3309 9129340 25.759 µM 0.945591762820841 0.210597640442083 no 723 0.172178423608165 917 17158987
SGTC_35 0133-0054 64.071 µM 0.944939225685079 0.21077266229784 no 724 0.172344952045263 806 99677
SGTC_1863 st057641 20.1 µM 0.944322915322881 0.210938045816485 no 725 0.172502329675719 931 3921635
SGTC_2851 9015922 71.43 µM 0.943966937669707 0.211033605129785 no 726 0.172593271917746 837 2996893
SGTC_1032 k061-1018 98.7 µM 0.943236836947382 0.211229674122101 no 727 0.172779887670342 938 4005393
SGTC_1960 st011366 51.8 µM 0.943140590453759 0.211255529136575 no 728 0.172804498129818 871 3972846
SGTC_679 0422-0091 41.4 µM 0.942438390969708 0.211444219413984 no 729 0.172984119831428 894 627384 YHR062C RPP1
SGTC_2623 humulene 100 µM 0.940135273757872 0.21206378974722 no 730 0.173574088708641 729 6187145 An anti-inflammatory.
SGTC_307 1501-1223 22.3 µM 0.932771181533162 0.214051942509115 no 731 0.175469061825299 849 2830329
SGTC_1427 4048-4900 550 nM 0.932696550782116 0.21407214664074 no 732 0.175488333143152 890 24132586
SGTC_2269 7935389 174.42 µM 0.930692534615933 0.214615091349695 no 733 0.176006316241677 830 97605
SGTC_441 propafenone 146 µM 0.92973621899757 0.214874466173394 no 734 0.17625383839133 859 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_282 k297-0036 65.7 µM 0.927977848775234 0.215351851585355 no 735 0.176709530054434 853 5061378
SGTC_1662 st014054 52 µM 0.926006445466354 0.215887805039517 no 736 0.177221315318669 850 2838777
SGTC_1390 3413-2614 145 µM 0.923913888063222 0.216457540661641 no 737 0.177765575833714 909 3421432
SGTC_944 3370-0224 231 µM 0.922938185885318 0.216723489919965 no 738 0.178019709667349 877 4580514
SGTC_628 1636-0253 16 µM 0.922614070739823 0.216811876482849 no 739 0.178104180171882 887 4456143
SGTC_828 2074-0507 139 µM 0.92224873390245 0.216911529229306 no 740 0.178199424111899 903 X828
SGTC_2930 9013230 14.89 µM 0.922144287850748 0.216940023792551 no 741 0.178226659276399 907 2995857
SGTC_2082 5219693 150 µM 0.921997793056812 0.21697999357444 no 742 0.178264863415241 884 2834649
SGTC_2607 solasodine 47.35 µM 0.920785456146755 0.217310932070596 no 743 0.178581224837455 879 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3351 9150312 21.596 µM 0.918040142193845 0.218061412471925 no 744 0.179298925222282 859 4904905
SGTC_690 glyoxal 20.3 µM 0.916383533647188 0.218514997735817 no 745 0.179732884377878 857 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2864 9034755 47.6 µM 0.913568831026208 0.21928691764282 no 746 0.180471725272871 947 4930451
SGTC_1882 5615643 20 µM 0.912351369014486 0.21962128623198 no 747 0.180791890448671 859 2253075
SGTC_1313 1220-0047 237 µM 0.912199654216742 0.219662974291745 no 748 0.180831812969233 936 3528706
SGTC_543 3844-1095 191 µM 0.911114282071552 0.219961344403397 no 749 0.181117581012108 910 4230703
SGTC_349 k015-0014 24 µM 0.91101847357373 0.219987693440167 no 750 0.181142820049005 835 2196908
SGTC_176 1486-1328 72.834 µM 0.91076626494202 0.220057063946417 no 751 0.18120927043944 922 22310231
SGTC_669 0108-0021 26.2 µM 0.910712792019429 0.220071773396672 no 752 0.181223361120038 989 17201
SGTC_2430 5571206 200 µM 0.909507662647194 0.220403432625479 no 753 0.181541107445725 998 1731771
SGTC_2684 capsaicin 100 µM 0.907153044265578 0.221052264529535 no 754 0.182162935340641 887 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1261 0712-0010 12.7 µM 0.906999462055497 0.221094623143554 no 755 0.182203540851641 928 2840123
SGTC_1809 st050081 57.6 µM 0.906441070924354 0.221248668881874 no 756 0.182351221226985 892 5036894
SGTC_2123 5259487 200 µM 0.904886456410451 0.221677870250312 no 757 0.182762771389842 921 2173474
SGTC_2628 lathosterol 100 µM 0.902323156359173 0.222386589603464 no 758 0.18344261404597 916 6710616
SGTC_202 3594-0513 34.79 µM 0.900795622299067 0.222809546889281 no 759 0.183848497788883 876 708429
SGTC_2620 irigenin 100 µM 0.899450419056188 0.223182398054881 no 760 0.184206396893814 927 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_826 1683-5028 118 µM 0.899340438084109 0.223212897276751 no 761 0.184235677130364 898 722377
SGTC_1615 st002656 86.5 µM 0.899249309595597 0.223238170245359 no 762 0.184259940463928 890 1584458
SGTC_2657 nystatin 74.44 µM 0.89885067995875 0.223348742680231 no 763 0.184366100611099 931 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.898314100819998 0.223497628934928 no 764 0.184509058537907 886 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3261 9137475 49.47 µM 0.895632808491312 0.224242460689349 no 765 0.18522445357428 733 17027690
SGTC_1789 tunicamycin 25 nM 0.895048587738275 0.224404937205002 no 766 0.185380557643357 908 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_460 trequinsin 123 µM 0.89469935432723 0.224502093740282 no 767 0.185473911973217 970 5537 A vasodilator.
SGTC_2612 dictamnine 15.46 µM 0.894568414380566 0.224538527309874 no 768 0.185508921330224 875 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2565 isoliquiritigenin 100 µM 0.894341223067669 0.224601750435548 no 769 0.185569675104338 742 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2877 9040724 71.43 µM 0.893481640714837 0.224841047614715 no 770 0.185799649797151 928 6463895
SGTC_289 k017-0060 526 µM 0.89233645736247 0.225160077057173 no 771 0.186106309357101 916 5512909
SGTC_3005 9076496 71.4286 µM 0.89154707126735 0.225380136399488 no 772 0.186317875346112 910 21368410
SGTC_2198 6589944 200 µM 0.890374165121404 0.225707335464454 no 773 0.186632504884109 838 5290268
SGTC_1674 st016616 23.6 µM 0.889336065396402 0.225997152376504 no 774 0.18691124713633 887 625830
SGTC_2137 5261020 140 µM 0.888782706914003 0.22615172503873 no 775 0.187059935739859 905 763655
SGTC_2222 6885208 172.143 µM 0.888422080020133 0.22625249307455 no 776 0.187156876323176 911 609514
SGTC_808 0711-0032 135 µM 0.885159703165669 0.227165233395848 no 777 0.188035251345147 941 4252555
SGTC_1347 1493-0251 600 nM 0.883171736426579 0.227722438330367 no 778 0.188571744915228 992 3986378
SGTC_1447 4239-0816 81.9 µM 0.880741229301432 0.228404726459283 no 779 0.189228947948315 866 1341554
SGTC_608 k048-0125 159 µM 0.879319117309 0.228804471573809 no 780 0.18961413661557 959 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2009 4012297 12.05 µM 0.877679248568362 0.229265913631118 no 781 0.190058904489934 867 45595307
SGTC_2476 5806916 10.51 µM 0.877509373099997 0.229313744633763 no 782 0.19010501501387 901 2870194
SGTC_903 1134-0042 114 µM 0.876294374130484 0.229656008984625 no 783 0.19043501133696 923 701009
SGTC_2516 gossypol 71.55 µM 0.874847918980826 0.230063847217948 no 784 0.190828330006762 965 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1219 1469-0211 33.1 µM 0.874687478890413 0.230109109388772 no 785 0.190871987407162 939 6822282
SGTC_500 h-89 112 µM 0.874276880686534 0.230224967002286 no 786 0.190983743310004 993 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1682 st012968 530 nM 0.872116604379619 0.23083506463858 no 787 0.191572384349562 841 24207270
SGTC_1530 rhein 70.4 µM 0.871892091619905 0.230898522494942 no 788 0.191633624205388 1018 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2271 7849410 118.62 µM 0.869535314495274 0.231565245948393 no 789 0.192277200494895 948 972430
SGTC_2575 plumbagin 510 nM 0.869342630896282 0.231619802833007 no 790 0.192329875911203 910 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1897 st060201 15 µM 0.869075710906752 0.231695391016881 no 791 0.192402860486644 890 611878
SGTC_2345 9052315 157.45 µM 0.86698097950043 0.232289068013516 no 792 0.192976215695168 919 6469265
SGTC_1365 1672-3266 55.4 µM 0.866280595432543 0.232487755565986 no 793 0.193168152438092 970 6415873
SGTC_1186 1319-0216 26 µM 0.866200499292388 0.232510483556716 no 794 0.193190109806832 1004 4565136
SGTC_682 0kpi-0099 17 µM 0.865947816407832 0.232582192664489 no 795 0.193259389686302 949 1714895 YML126C ERG13
SGTC_798 1287-0182 476 µM 0.864686823413502 0.232940234748739 no 796 0.19360535177485 1020 1649755
SGTC_2043 5101342 149 µM 0.863194033575399 0.23336448789426 no 797 0.194015396784805 919 678451
SGTC_2085 5307070 144.047 µM 0.862028885258658 0.233695922500356 no 798 0.194335811408378 902 2840351
SGTC_2506 ethyl hematommate 54.16 µM 0.858331065542002 0.234749519537889 no 799 0.195354840093148 886 3940691 An allergen.
SGTC_946 3434-1334 87.4 µM 0.858271334320366 0.234766559912599 no 800 0.195371327153482 937 4047976
SGTC_428 3448-4153 16.5 µM 0.858087535024452 0.234818999239846 no 801 0.19542206488649 878 3834874
SGTC_3156 9099931 49.47 µM 0.85716188751846 0.235083191850791 no 802 0.195677711195502 1012 18111053
SGTC_3349 9149703 23.001 µM 0.854424916155425 0.235865320991299 no 803 0.196434797651804 989 4910494
SGTC_2785 7756463 72.73 µM 0.854291124028968 0.235903590765088 no 804 0.196471851972158 977 2201551
SGTC_2218 6965428 192.983 µM 0.853143161437149 0.236232093531438 no 805 0.196789959340737 973 675684
SGTC_298 1391-0729 10 µM 0.85279342560826 0.236332224526463 no 806 0.196886935203052 954 3237558
SGTC_912 3474-0017 2.18 µM 0.852772800339506 0.236338130366462 no 807 0.196892655146454 986 3360550
SGTC_2655 perillic acid 100 µM 0.850260517210463 0.237058104992794 no 808 0.197590131294146 940 5702197 An apoptosis inducer.
SGTC_2635 hydroquinidine 100 µM 0.84980257599492 0.237189472365145 no 809 0.197717428616957 961 442912 An experimental heart treatment.
SGTC_2808 7946468 45.46 µM 0.849598388286958 0.23724805958971 no 810 0.197774204163788 975 2970879
SGTC_563 tetrahydrosecaminediol 614 µM 0.847724136651041 0.237786206518513 no 811 0.198295810515478 1022 334274 A psychoactive constituent of the cannabis plant.
SGTC_2789 5281112 71.43 µM 0.847461988098703 0.237861529596021 no 812 0.198368832883322 947 765948
SGTC_360 0957-0399 1.01 µM 0.847028163053504 0.23798620917459 no 813 0.198489711960858 990 6752301 YPR165W RHO1
SGTC_2658 polymyxin b sulfate 77.05 µM 0.846632803465341 0.238099865130077 no 814 0.198599911887588 978 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2148 5546263 113.568 µM 0.846312265405495 0.238192033605291 no 815 0.198689283635252 971 792097
SGTC_741 4582-0002 126 µM 0.846206423048872 0.238222472126552 no 816 0.19871879970385 949 2912688
SGTC_275 trichlorophene 5.69 µM 0.84617875242169 0.238230430095271 no 817 0.198726516598063 1062 62616
SGTC_1109 tnp00067 928.257 nM 0.844622024333989 0.238678373757992 no 818 0.199160954079284 958 676295
SGTC_230 MPP+ 141.667 µM 0.843922734998278 0.238879742003118 no 819 0.199356291440266 928 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3303 9125618 40.5795 µM 0.843188983754099 0.239091133798818 no 820 0.199561379261397 1017 22695467
SGTC_1102 cgs 12066b 26.1 µM 0.842077143640072 0.239411646761169 no 821 0.199872387030829 949 6438352 A 5-HT1B full agonist.
SGTC_2529 gangaleoidin 93.61 µM 0.841423680760114 0.239600131587048 no 822 0.20005531186257 985 4565183
SGTC_2941 9056145 11.23 µM 0.837880051633306 0.240623665164482 no 823 0.201049036697499 912 2119517
SGTC_2585 alliin 100 µM 0.837176730094563 0.240827093633101 no 824 0.201246617717089 996 87310 A garlic compound which reacts with lipids.
SGTC_3278 9139605 49.47 µM 0.836473217522558 0.241030670930338 no 825 0.201444368821055 955 7958859
SGTC_918 glabranin 770.725 nM 0.836059555421134 0.241150417103767 no 826 0.201560699892539 986 124049 Also referred to as licorice root.
SGTC_2239 6685329 187.64 µM 0.835349580689069 0.241356014696287 no 827 0.201760454525603 960 805680
SGTC_2336 9001819 198.65 µM 0.835166680921063 0.241408995035069 no 828 0.2018119334084 1009 2989602
SGTC_1798 st045719 60.953 µM 0.834696840173956 0.241545122150237 no 829 0.20194421061135 956 3980186
SGTC_713 1488-1073 324 µM 0.833850132601834 0.241790544224555 no 830 0.202182720486897 1009 3312542
SGTC_2921 7974240 10.71 µM 0.833244101571717 0.241966288156365 no 831 0.202353537392175 967 2979074 YDR527W RBA50
SGTC_2194 5927483 104.545 µM 0.832517779481049 0.242177006739655 no 832 0.202558373399968 1036 760979
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.831816650341329 0.242380510741136 no 833 0.202756222064107 1056 1377
SGTC_2985 9022375 71.43 µM 0.829886098811005 0.24294133529959 no 834 0.203301592587701 1018 4939335
SGTC_2012 4023501 200 µM 0.828347351927713 0.243388843025283 no 835 0.203736906677403 936 3477460
SGTC_3288 9119690 36.221 µM 0.82735634028129 0.243677290701245 no 836 0.204017559500597 933 17595618 YKL019W RAM2
SGTC_2896 9052656 71.43 µM 0.8270390791653 0.243769672934183 no 837 0.204107455962479 1010 6469436
SGTC_225 nsc-122657 1.016 µM 0.826778003196701 0.243845708974294 no 838 0.204181449964086 889 275685
SGTC_224 benfluorex 43.875 µM 0.825427244285352 0.244239309765074 no 839 0.204564536359875 1005 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_228 caffeine 993.056 µM 0.825200169809156 0.244305511139305 no 840 0.204628978525284 963 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1237 0330-0133 46.1 µM 0.823873931345798 0.244692356312245 no 841 0.205005597033527 962 X1237 YHR072W ERG7
SGTC_2324 6149169 200 µM 0.823102548203327 0.2449175095797 no 842 0.205224839925429 972 2888231
SGTC_2712 st079126 47.7 µM 0.822725652326753 0.245027559432558 no 843 0.205332012096479 967 3152970
SGTC_674 0498-0004 451 µM 0.820655440690915 0.245632514731053 no 844 0.205921279367903 966 4231473
SGTC_1438 4092-1045 4 µM 0.819576581262887 0.24594809567169 no 845 0.206228764271515 1024 1351342
SGTC_1187 1391-0724 117 µM 0.819316452846336 0.246024219283754 no 846 0.206302943975948 1014 6997986
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.819221031004294 0.246052146565218 no 847 0.206330158977132 981 803109
SGTC_1956 st077085 54 µM 0.818186118014728 0.246355145616769 no 848 0.206625460313659 1033 24208685
SGTC_293 4049-0273 38.5 µM 0.814633441449535 0.24739680864497 no 849 0.207641081172042 961 1380311
SGTC_1207 2099-0101 141 µM 0.814400307673607 0.247465246878598 no 850 0.207707831221017 1066 5837381
SGTC_1717 st033143 58.0435 µM 0.813802519595974 0.247640778438352 no 851 0.207879045730513 1033 674616
SGTC_2225 6654152 15.4 µM 0.813419139288651 0.247753387342969 no 852 0.207988894834253 974 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1780 st038448 24.544 µM 0.812393357633686 0.248054820857937 no 853 0.208282978221934 1010 728868 YDL195W SEC31
SGTC_2887 9044784 58.44 µM 0.812240815919008 0.248099663072904 no 854 0.208326731653225 1091 6465546
SGTC_1260 0700-1617 7.75 µM 0.812227819543342 0.248103483777063 no 855 0.208330459645024 1006 2853078
SGTC_486 niguldipine 82 µM 0.811991827722767 0.248172866649719 no 856 0.208398160406593 977 1236 A calcium channel blocker.
SGTC_472 calcifediol 10 µM 0.806163246244024 0.249889780245139 no 857 0.210074363888776 966 5283731 A vitamin D metabolite.
SGTC_3245 9134821 49.47 µM 0.806063771746153 0.249919136869266 no 858 0.210103039680717 1039 17014901
SGTC_3328 9140624 29.0385 µM 0.805657848588009 0.250038950701948 no 859 0.210220080120909 1057 4904392
SGTC_899 1083-0020 478 µM 0.805634459789599 0.250045855157658 no 860 0.210226825015158 1023 767123
SGTC_1703 st026983 48.3 µM 0.80328613807168 0.250739602644139 no 861 0.210904684074232 1063 1104023
SGTC_2829 7992743 58.44 µM 0.803029634092101 0.250815441434111 no 862 0.210978803255124 1052 16462845
SGTC_1762 st045503 25.4615 µM 0.802873038868133 0.250861746850056 no 863 0.211024060389652 1077 4645554
SGTC_476 mead acid 10 µM 0.802723701724001 0.250905910257423 no 864 0.2110672251883 1031 5312531 An omega 9 fatty acid.
SGTC_3147 9097027 49.47 µM 0.801423620726443 0.251290556422303 no 865 0.211443222581347 1059 25236841
SGTC_2058 5236698 133 µM 0.800889078471141 0.251448798220905 no 866 0.211597931668661 1008 766665
SGTC_1253 0550-0034 176 µM 0.800842354318109 0.251462632583949 no 867 0.211611457884894 985 5969915
SGTC_2274 7947094 46.08 µM 0.799454016062031 0.251873883445803 no 868 0.212013600057981 1089 2971028
SGTC_2326 6164455 177.58 µM 0.799386557502732 0.251893874929534 no 869 0.212033151294672 992 2888790
SGTC_2717 st081029 62.2815 µM 0.798847080744717 0.252053780109659 no 870 0.212189543551839 1030 5292846
SGTC_1434 4073-0095 163 µM 0.797660475298178 0.252405687715285 no 871 0.212533773140034 1080 24133745
SGTC_552 k242-0005 476 µM 0.796030668896258 0.252889455719824 no 872 0.213007104886047 1023 4088318
SGTC_1919 st067113 52.3 µM 0.795698638228586 0.252988070674164 no 873 0.213103609278878 1008 1268243
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.794877860650538 0.253231932987232 no 874 0.213342276908611 994 689007
SGTC_1619 st003326 88.7 µM 0.794461562742426 0.253355667038598 no 875 0.213463388530829 1037 2849032
SGTC_3223 9129970 49.47 µM 0.793501082902834 0.253641266642784 no 876 0.213742969312968 1077 17248386
SGTC_2086 5274770 176.623 µM 0.79285708880107 0.253832853562961 no 877 0.213930545387991 1010 689278
SGTC_2839 9003951 25.97 µM 0.791921941341141 0.254111193196449 no 878 0.214203096212711 1042 2990634
SGTC_1781 st038725 66.3 µM 0.791540014884862 0.254224916770128 no 879 0.214314467612587 1066 4270275 YIL048W NEO1
SGTC_41 0478-0632 82.643 µM 0.790324326614243 0.254587081366821 no 880 0.214669191699612 1104 3750424
SGTC_447 ml7 120 µM 0.787993080454303 0.255282336100183 no 881 0.215350376671882 1085 4216 Selective myosin light chain kinase inhibitor.
SGTC_2828 7998861 71.43 µM 0.787227139303172 0.255510981532901 no 882 0.215574456408489 986 2988188
SGTC_1933 st074711 15.9 µM 0.786425075545524 0.255750524754756 no 883 0.215809248850396 1100 17250958
SGTC_1240 0356-0016 42.1 µM 0.785382327465868 0.256062125621092 no 884 0.216114719599653 1018 4305613
SGTC_641 4092-0595 30 µM 0.785187637478605 0.256120326099127 no 885 0.216171781331629 1064 786260
SGTC_972 1319-0219 195 µM 0.784736130844866 0.256255325698732 no 886 0.216304147084927 1023 23903702
SGTC_3110 9122132 49.47 µM 0.782772286869214 0.256842942488868 no 887 0.216880422166279 1092 918317
SGTC_164 4100-3994 89.624 µM 0.782115353372531 0.25703966500085 no 888 0.217073392233481 1104 4615967
SGTC_3059 1327-0034 3 µM 0.780996103548885 0.257375011216619 no 889 0.217402393206311 1035 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3165 9101544 49.47 µM 0.778928891329819 0.257994980221465 no 890 0.218010801914076 1066 5002184
SGTC_124 0136-0217 7.121 µM 0.778337102906672 0.258172603534664 no 891 0.218185153865674 1218 3976905
SGTC_1168 k815-0004 80.5 µM 0.775706167782787 0.258963036674481 no 892 0.218961248655071 1076 642433
SGTC_872 0588-0139 234 µM 0.775316514235746 0.259080209777598 no 893 0.219076326699759 1111 2047100
SGTC_2375 9072683 200 µM 0.77517504118838 0.259122759059929 no 894 0.219118117142862 1160 16798029
SGTC_3295 9122362 53.5725 µM 0.775140933706426 0.259133017730176 no 895 0.219128193011149 1055 4730473
SGTC_1144 3486-0183 12.5 µM 0.77479095221695 0.259238295464311 no 896 0.219231598249751 1079 6744069
SGTC_3296 9122258 64.045 µM 0.773787734824789 0.259540195175212 no 897 0.219528163411074 1069 4730474
SGTC_1203 3992-3522 103 µM 0.773116180159223 0.259742388518246 no 898 0.219726813099691 1130 5322312
SGTC_264 promethazine 12.5 mM 0.772266481408781 0.259998334370831 no 899 0.21997830665992 1168 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_759 3486-0358 89.3 µM 0.772211475401808 0.260014907735145 no 900 0.219994593010085 1116 875103
SGTC_1913 st060213 96.1 µM 0.77062849925585 0.260492093331466 no 901 0.220463581870779 1110 688959
SGTC_488 nitrendipine 139 µM 0.770192661527289 0.260623555037116 no 902 0.22059280818283 1093 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_79 0052-0007 94.094 µM 0.76992380200128 0.260704668146092 no 903 0.220672546932399 1079 2801472
SGTC_2737 bleomycin 30.5 nM 0.768841082223546 0.261031448865022 no 904 0.220993828611375 1133 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1092 toremifene 6.32 µM 0.768316801482427 0.261189760127537 no 905 0.221149497613763 1128 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1395 3486-0190 4.35 µM 0.767963939557697 0.261296337716059 no 906 0.221254304395665 1128 6748079
SGTC_3090 9117696 49.47 µM 0.767845905115692 0.261331993548092 no 907 0.221289369236574 1073 7923821
SGTC_1548 st061468 90.8 µM 0.766746947694387 0.261664086409302 no 908 0.221615992286564 1110 390799
SGTC_2427 5545055 42.75 µM 0.766661586369316 0.261689890725164 no 909 0.221641374200746 1122 5372858
SGTC_2541 muurolladie-3-one 83.07 µM 0.765202825193286 0.262131068912944 no 910 0.222075388813366 1053 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1426 4048-4480 71.7 µM 0.764079947383441 0.262470924158685 no 911 0.222409800678378 1091 14224343
SGTC_1167 k781-0610 148 µM 0.761957258859429 0.26311400231148 no 912 0.223042757007807 1089 4525169
SGTC_761 k216-0224 480 µM 0.761207804518998 0.263341245065801 no 913 0.223266478709512 1137 1340404
SGTC_833 3852-0053 558 µM 0.759734912570808 0.263788133839175 no 914 0.223706527735734 1132 3123681
SGTC_317 4495-0002 170 µM 0.758362620466559 0.264204847431478 no 915 0.22411696439196 1035 15991618
SGTC_2170 morpholine 200 µM 0.757482041091477 0.264472422812073 no 916 0.224380560594113 1090 121171 Reacts with secondary amines.
SGTC_2517 totarol 10 µM 0.756004050125929 0.264921839166845 no 917 0.224823383707723 1073 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2147 5545932 89.7195 µM 0.753671157928858 0.265631996365841 no 918 0.22552335234357 1089 797404
SGTC_1825 st052143 62.6 µM 0.752792483806772 0.265899724176827 no 919 0.225787312047993 1086 674173
SGTC_1680 diphenhydramine 100 µM 0.752660067315623 0.265940082701831 no 920 0.225827106011685 1053 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2791 5663188 71.43 µM 0.75197017911851 0.266150400286716 no 921 0.226034496200109 1077 54690634
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.749827886743454 0.266804030522081 no 922 0.226679185466092 1022 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1114 scopoletin 1.73284 µM 0.749664504803058 0.266853912906426 no 923 0.226728395248821 1116 5280460 A coumarin with genotoxic properties.
SGTC_211 3455-0679 143.504 µM 0.747064457708856 0.267648370805108 no 924 0.227512326621342 1148 748649
SGTC_2433 5607874 27.82 µM 0.74655054548172 0.267805540342219 no 925 0.227667455031451 1129 2252428
SGTC_2893 9048488 25.97 µM 0.746276705250513 0.267889307757542 no 926 0.227750140151078 1093 6467338
SGTC_994 3910-0338 138 µM 0.744975712974009 0.268287460014069 no 927 0.228143201127267 1155 3479481
SGTC_1352 1496-0991 99 µM 0.743780913656496 0.268653375300233 no 928 0.228504514416335 1130 3000039
SGTC_1512 0259-0544 12.2 µM 0.743665714119978 0.268688669179919 no 929 0.22853936831524 1135 18476
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.74355877953971 0.268721432995559 no 930 0.228571724304004 1150 551469
SGTC_3256 9138902 49.47 µM 0.743092878084285 0.268864204525602 no 931 0.228712725583048 1154 17228773
SGTC_2925 9010536 32.5 µM 0.742706817794032 0.268982538263366 no 932 0.228829600575335 1114 2994177
SGTC_1005 4092-0690 4.4 µM 0.742634554328548 0.269004691091568 no 933 0.22885148117263 1089 1529343
SGTC_2350 9023895 38.85 µM 0.742582159224452 0.269020753719022 no 934 0.228867346578931 1108 2997209
SGTC_400 oxethazaine 37.5 µM 0.741374156624631 0.269391221303204 no 935 0.229233304799967 1068 4621 A local anesthetic.
SGTC_2133 5320837 200 µM 0.741118446232228 0.26946967479373 no 936 0.229310813016483 1087 2841355
SGTC_3134 9127454 49.47 µM 0.739232659054607 0.270048599081739 no 937 0.229882866270804 1188 24262820
SGTC_438 sphingosine 6.67 µM 0.737634009078095 0.270539861035666 no 938 0.230368441540591 1059 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.73731051453245 0.270639324551042 no 939 0.230466769758956 1140 260807
SGTC_1480 1070-0044 41.2 µM 0.736651525098395 0.270841997755256 no 940 0.230667146329279 1135 3124987
SGTC_1952 st077036 64.1 µM 0.735055646381062 0.271333126333105 no 941 0.231152802522299 1158 2937007
SGTC_3146 9095609 49.47 µM 0.734001623626064 0.271657742977915 no 942 0.231473874268224 1115 17173999
SGTC_249 wiskostatin 11.211 µM 0.732955567997884 0.271980096962584 no 943 0.231792764787942 1153 2775510 A n-wasp and actin depolymerizer.
SGTC_82 0054-0107 293.755 µM 0.731852537408934 0.2723202143721 no 944 0.232129289083235 1138 3104697
SGTC_37 0566-0070 1.56 µM 0.73024890711703 0.272815067386277 no 945 0.232619026375049 1153 1626686
SGTC_301 4119-0100 24.5 µM 0.730132452692034 0.272851020605041 no 946 0.232654613084806 1153 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_987 1497-1013 404 µM 0.729813702552958 0.272949441021697 no 947 0.232752033778654 1141 1676435
SGTC_3010 9080089 71.4286 µM 0.7295690617672 0.273024990646134 no 948 0.232826819551411 1140 17027233
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.728410375438296 0.273382955291506 no 949 0.233181206929403 1170 688664
SGTC_218 alverine citrate 93.75 µM 0.728251382822681 0.273432092609111 no 950 0.233229858606952 1109 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2192 5915882 198.485 µM 0.727237240498546 0.273745620297758 no 951 0.233540318302661 1097 2876149
SGTC_1740 st038286 13.222 µM 0.725875284584553 0.274166956025617 no 952 0.233957614613326 1143 716786
SGTC_1500 4488-1866 171 µM 0.725711067253457 0.274217780057165 no 953 0.234007957852789 1195 2900003
SGTC_643 k048-0106 28.4 µM 0.725628660123176 0.274243286198774 no 954 0.234033223232224 1145 6763920
SGTC_2875 9039966 71.43 µM 0.720658160611407 0.275783887115937 no 955 0.235559930219771 1192 6463691
SGTC_633 0437-0093 97.7 µM 0.719880564132157 0.276025286469649 no 956 0.235799267842601 1189 2831118
SGTC_1214 0358-0031 63.7 µM 0.718925035724022 0.276322065556433 no 957 0.236093554921155 1150 4301366
SGTC_585 0kpi-0023 191 µM 0.71825502398275 0.276530258893093 no 958 0.236300028174191 1111 64601
SGTC_1970 st070122 35.8 µM 0.717622802637132 0.276726780079813 no 959 0.236494946938864 1196 102928
SGTC_1794 st048918 76.9 µM 0.717071301409994 0.276898265894243 no 960 0.236665051298327 1106 672303
SGTC_1958 st076513 41.9 µM 0.716272449878541 0.277146755963083 no 961 0.236911567390928 1143 732122 YGL099W LSG1
SGTC_42 0133-0086 60.653 µM 0.715149071745406 0.277496377493514 no 962 0.237258467236771 1136 162923 Model of phenazepam hydroxylation.
SGTC_407 eburnamonine 100 µM 0.714638348253534 0.277655397826909 no 963 0.237416271162366 1079 3195
SGTC_14 0354-0009 295 µM 0.714591791526583 0.27766989607676 no 964 0.237430659178127 1204 1713507
SGTC_2195 6536160 144.242 µM 0.713787481230467 0.277920425045136 no 965 0.237679300944278 1078 3834386
SGTC_2909 7941780 10.49 µM 0.711994696804268 0.278479243585757 no 966 0.238234029987501 1181 1243215
SGTC_123 0083-0120 66.675 µM 0.711685328493189 0.278575730360768 no 967 0.238329827419174 1130 16001701
SGTC_2181 6316240 54.2555 µM 0.710999832060609 0.278789583165205 no 968 0.238542169936513 1158 12779990
SGTC_1469 k284-2957 126 µM 0.710737269646486 0.278871515338375 no 969 0.238623529894791 1200 23884841
SGTC_1826 st055655 41.6 µM 0.708531303972724 0.27956034567979 no 970 0.239307689748744 1169 676168
SGTC_714 4296-0578 26.1 µM 0.708164024807517 0.279675111687394 no 971 0.239421701951479 1183 1589775
SGTC_2961 9083290 32.55 µM 0.706910621893181 0.280066942373784 no 972 0.239811011337792 1137 17741490
SGTC_2913 7966556 36.57 µM 0.706663759461262 0.280144146257424 no 973 0.239887727977083 1107 2976516
SGTC_2161 5662504 8.5105 µM 0.705791861403804 0.280416906608759 no 974 0.24015879201664 1149 2859334
SGTC_2342 7990637 118.86 µM 0.705388560402449 0.280543116810672 no 975 0.240284230551348 1218 2033102 YER133W GLC7
SGTC_1523 st012844 44.7 µM 0.704698660672629 0.28075907977547 no 976 0.240498892504187 1187 4274103
SGTC_2092 5303694 80.6725 µM 0.70329460930282 0.281198845557888 no 977 0.240936084726523 1175 1963699
SGTC_738 1315-0003 72.4 µM 0.703032918605785 0.281280846994622 no 978 0.241017617501518 1187 6251474
SGTC_3284 9108171 64.8615 µM 0.702737088642449 0.281373559955705 no 979 0.241109804825931 1133 8687505
SGTC_1378 2093-0007 380 nM 0.701251601745088 0.281839333638605 no 980 0.241573005908925 1189 3618014
SGTC_2273 7815444 169.05 µM 0.700255771734038 0.282151783529907 no 981 0.241883793643108 1155 2824616
SGTC_3088 9117578 49.47 µM 0.69994103819014 0.28225056844613 no 982 0.241982063660057 1244 678341
SGTC_1241 0364-0022 50.8 µM 0.696773629335594 0.283245643504297 no 983 0.24297223589869 1182 4563895
SGTC_2369 9071472 200 µM 0.696224522721473 0.283418322159728 no 984 0.243144116249251 1216 17296037
SGTC_1776 st049249 45.9 µM 0.696176240907373 0.283433507851828 no 985 0.243159232478494 1203 1822314
SGTC_1215 3852-0577 11.2 µM 0.69454115859528 0.28394800731223 no 986 0.243671449279283 1244 2884876
SGTC_417 st075190 100 µM 0.693403686882205 0.284306190664428 no 987 0.244028124584945 1203 222757
SGTC_1827 berberine 7.24 µM 0.692532288755877 0.284580734973198 no 988 0.244301557989216 1135 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_719 2810-4230 27.3 µM 0.692328362758718 0.284645002551619 no 989 0.244365571153675 1181 721079
SGTC_2270 7924575 90.91 µM 0.691555883112319 0.284888513468507 no 990 0.2446081374752 1185 1262135
SGTC_2421 5690543 90.72 µM 0.691441261527257 0.284924654416107 no 991 0.244644140842372 1209 3397993
SGTC_755 1995-0008 37.3 µM 0.691074374648972 0.28504035098776 no 992 0.244759401522328 1213 689533
SGTC_2371 9071574 200 µM 0.689042757122407 0.285681420009729 no 993 0.245398180515135 1179 45596039
SGTC_2437 5741531 144.16 µM 0.688241247523616 0.285934521811664 no 994 0.245650436528296 1266 2262990
SGTC_2072 5231554 129 µM 0.687875170010918 0.286050157721804 no 995 0.245765696996578 1274 789545
SGTC_2504 purpurogallin 52.29 µM 0.687292831635457 0.286234151503823 no 996 0.245949107579127 1150 5281571 An antioxidant.
SGTC_1245 0418-0076 17.2 µM 0.685564302026909 0.286780622968982 no 997 0.246493949501074 1208 6790114
SGTC_960 1222-0186 7.7 µM 0.683513075701722 0.287429755334224 no 998 0.247141345308881 1202 3126296
SGTC_1400 3771-8998 51.5 µM 0.683062241036037 0.287572519855055 no 999 0.247283756862065 1170 670767
SGTC_591 4299-0174 154 µM 0.680703339982354 0.288320052313754 no 1000 0.248029611262221 1185 5509088
SGTC_3236 9132701 49.47 µM 0.679520212934235 0.288695328343841 no 1001 0.248404152411292 1194 24282524
SGTC_2853 9015042 58.44 µM 0.675621652409461 0.289933537630893 no 1002 0.249640445340435 1175 6457456
SGTC_2903 5923464 63.88 µM 0.675063075934448 0.290111149079069 no 1003 0.249817845743818 1259 2876576
SGTC_2029 5175081 200 µM 0.674490759476595 0.290293182321341 no 1004 0.249999679274407 1236 1380876
SGTC_2213 7173844 200 µM 0.672536322335095 0.290915221265058 no 1005 0.250621162337393 1221 892728
SGTC_2827 7993847 71.43 µM 0.670921458681291 0.291429653624869 no 1006 0.251135282677718 1195 2985692
SGTC_3053 9095903 49.47 µM 0.669935298981388 0.291744014075415 no 1007 0.251449518159823 1290 17174018
SGTC_2702 st077768 96.8 µM 0.668059559278332 0.292342383761866 no 1008 0.252047787452399 1175 6484119
SGTC_550 4123-0385 25.7 µM 0.667173092361534 0.292625369282731 no 1009 0.252330788181881 1243 5731123
SGTC_546 peri-Naphthalide 147 µM 0.666479435648208 0.292846892998951 no 1010 0.252552351854946 1197 223824 A penicillin ester.
SGTC_1088 bifonazole 369 nM 0.665832283251812 0.293053635430059 no 1011 0.25275915378022 1192 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1026 k007-1105 30.6 µM 0.665280892577826 0.293229838758634 no 1012 0.252935424723013 1252 7066794
SGTC_2131 toluylene red 5.2905 µM 0.66514515370797 0.29327322323204 no 1013 0.252978828230206 1228 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1230 0170-0365 3.77 µM 0.66432590613314 0.293535131969237 no 1014 0.253240871886291 1324 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_3036 9090181 49.47 µM 0.664085728837341 0.293611935796243 no 1015 0.25331772178597 1260 25236586
SGTC_636 0kpi-0074 126 µM 0.663392499195713 0.293833668736481 no 1016 0.253539604287053 1224 616434
SGTC_722 3534-0461 190 µM 0.66288497919583 0.293996050625443 no 1017 0.253702111288366 1228 658262
SGTC_3227 9130768 49.47 µM 0.660321914069558 0.294816740803154 no 1018 0.254523635072224 1268 17720899
SGTC_470 aa-861 153 µM 0.659102893330946 0.295207439934407 no 1019 0.254914848924083 1223 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2933 9026794 32.47 µM 0.659102108944316 0.295207691408961 no 1020 0.254915100754387 1257 17586027
SGTC_1552 6-methylflavone 10.6 µM 0.657472738816871 0.295730280616977 no 1021 0.255438497112601 1233 689013
SGTC_1146 3579-1023 7 µM 0.656478480120849 0.296049378712846 no 1022 0.25575815470464 1302 X1146
SGTC_247 mechlorethamine 29.705 µM 0.656053114974247 0.296185943957056 no 1023 0.255894974819456 1181 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1231 0242-0792 125 µM 0.655783966113303 0.296272370240718 no 1024 0.255981567172714 1248 3707635
SGTC_1922 5578187 25 µM 0.654411116576172 0.296713385250003 no 1025 0.256423487159559 1310 1350412
SGTC_3126 9127922 49.47 µM 0.654340891064453 0.296735952614733 no 1026 0.256446103420298 1292 45595682
SGTC_2089 5281248 129.67 µM 0.654070100737139 0.296822979972187 no 1027 0.256533321694116 1273 2737878
SGTC_2588 indole-3-carbinol 100 µM 0.653628039491834 0.296965075955942 no 1028 0.256675737443918 1254 3712 Induces cell cycle arrest.
SGTC_1288 0973-0013 65.5 µM 0.652099018294135 0.297456803696502 no 1029 0.257168648668912 1297 4315430
SGTC_518 1021-0119 62.6 µM 0.651988384972253 0.297492397397432 no 1030 0.257204332664972 1215 1097762
SGTC_89 0302-0250 142.109 µM 0.651091159687588 0.297781130598782 no 1031 0.257493821402776 1313 4203518 YLR208W SEC13
SGTC_1944 st076371 56.9 µM 0.650241785498276 0.298054582711481 no 1032 0.25776802690973 1242 24208455
SGTC_2601 securinine 100 µM 0.649205207059524 0.298388459317458 no 1033 0.258102873248275 1241 442872 A GABA receptor antagonist.
SGTC_3330 9141424 71.43 µM 0.648727242896795 0.298542466444565 no 1034 0.258257346142188 1272 27261020
SGTC_166 k072-0058 166.424 µM 0.647765710244875 0.298852395976494 no 1035 0.258568248288652 1274 5846229
SGTC_1117 retinoic acid 1.10837 µM 0.646537086368336 0.299248629267064 no 1036 0.258965793627091 1290 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_3240 9133527 49.47 µM 0.646052040047673 0.299405123128783 no 1037 0.259122826870245 1235 17617455
SGTC_2443 5493264 126.67 µM 0.645813154601735 0.299482210035233 no 1038 0.259200183875346 1282 5340055
SGTC_2566 crystal violet carbinol 226 nM 0.642871998024874 0.30043204005732 no 1039 0.260153580263753 1221 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_340 k038-0059 454 µM 0.64249798092784 0.300552924252936 no 1040 0.260274949929351 1270 23733424
SGTC_2120 5538279 151.968 µM 0.641638175720571 0.300830900838737 no 1041 0.26055406987454 1318 2058197
SGTC_1448 4255-0083 152 µM 0.63910813336508 0.301649540029074 no 1042 0.261376294597926 1342 5399660
SGTC_1075 aripiprazole 15.2 µM 0.638456753477726 0.301860467382226 no 1043 0.261588198518617 1304 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1861 st057647 17.4 µM 0.63837472810496 0.301887033223885 no 1044 0.261614888886876 1364 688668
SGTC_875 0709-0210 25.7 µM 0.637321146478075 0.302228353719287 no 1045 0.261957839741413 1305 6251364
SGTC_161 4065-0411 162.148 µM 0.637291047880331 0.302238107067568 no 1046 0.261967640507161 1297 1906281 YLR208W SEC13
SGTC_884 0851-0618 334 µM 0.634152949490674 0.303255771175097 no 1047 0.262990504982555 1275 9642473
SGTC_1711 st032263 62.8 µM 0.633269922659283 0.303542406745198 no 1048 0.263278695546595 1302 3958979
SGTC_1176 0848-0131 83.3 µM 0.632582289083434 0.303765700301616 no 1049 0.263503227904511 1342 6769040
SGTC_1655 st012546 55.1 µM 0.631343273197077 0.304168227769437 no 1050 0.263908049171438 1261 720985 YLR208W SEC13
SGTC_1651 st011928 86.1 µM 0.631249397737011 0.304198735407533 no 1051 0.263938733834214 1299 720198
SGTC_1346 1488-2224 62.4 µM 0.629864067563038 0.304649098257813 no 1052 0.264391762002433 1296 3722427
SGTC_3140 9094243 49.47 µM 0.626608534528022 0.305708618536625 no 1053 0.265457936275543 1315 19291112
SGTC_2297 7971671 152.32 µM 0.625109202220413 0.306197127811475 no 1054 0.26594969436525 1348 909016
SGTC_480 am 92016 50 µM 0.62466481355023 0.306341983865679 no 1055 0.266095535678969 1232 2129 K+ channel blocker.
SGTC_616 4092-0450 108 µM 0.624638885001896 0.306350436652422 no 1056 0.266104046267641 1332 787165
SGTC_1554 st069299 38.7 µM 0.622941101782484 0.306904143355595 no 1057 0.266661613507697 1303 24207999
SGTC_1419 3993-2473 62.6 µM 0.621222148948205 0.307465203328634 no 1058 0.267226734121509 1348 704026
SGTC_2641 levomentholum 100 µM 0.620493906629317 0.307703035001084 no 1059 0.267466332226297 1266 16666
SGTC_2533 agelasine 13.65 µM 0.619412531128287 0.308056343134659 no 1060 0.26782231401059 1365 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1412 3909-8563 178 µM 0.619238998953501 0.308113056326689 no 1061 0.267879461890468 1375 23767530
SGTC_3336 9143619 71.43 µM 0.61779368499978 0.308585586793178 no 1062 0.268355673363365 1333 45595730
SGTC_2926 9010726 65.15 µM 0.617397186690282 0.308715273294012 no 1063 0.26848638859844 1285 2994293
SGTC_2307 7538926 6.34 µM 0.617117387452074 0.308806804271827 no 1064 0.268578650429544 1328 96582
SGTC_1312 1218-2183 165 µM 0.615937333192735 0.309192967110311 no 1065 0.268967940261975 1325 6744073
SGTC_1121 fusaric acid 630.51 nM 0.615344105231851 0.309387175661564 no 1066 0.269163748040255 1319 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_930 2810-3379 265 µM 0.609900913854951 0.311171626026208 no 1067 0.270963723560641 1460 1015764
SGTC_1755 st041960 45.185 µM 0.605985773402444 0.312457886023108 no 1068 0.272262100159398 1348 2257073
SGTC_1914 st062367 72.6 µM 0.604568295965345 0.312924141787657 no 1069 0.272732938772273 1345 978205
SGTC_1342 1486-1464 234 µM 0.60429373694192 0.31301448807296 no 1070 0.272824184785185 1338 3253938
SGTC_219 mitoxanthrone 164.414 µM 0.602225496530231 0.313695423042422 no 1071 0.273512023065718 1356 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2184 6075246 200 µM 0.60189627250272 0.313803873432162 no 1072 0.273621592808107 1358 2267320
SGTC_1732 st034308 51.822 µM 0.601616431654582 0.313896069054098 no 1073 0.273714744303744 1318 830119
SGTC_2001 4023502 57.655 µM 0.601246854058136 0.314017846912485 no 1074 0.273837790784326 1369 108941 YCR052W RSC6
SGTC_3006 9075424 71.4286 µM 0.600749093201311 0.314181893873854 no 1075 0.27400355757623 1294 7465181
SGTC_3158 9100007 49.47 µM 0.6005319991556 0.3142534530225 no 1076 0.274075870841138 1325 19297233
SGTC_614 0462-0418 107 µM 0.59818365063197 0.315027968045311 no 1077 0.274858699638605 1250 5188303
SGTC_1668 st014914 51.6 µM 0.596949861374379 0.315435213756736 no 1078 0.275270428002942 1339 2839556
SGTC_2348 9022543 33.42 µM 0.59602281631705 0.315741357820847 no 1079 0.27557999224488 1365 3162678 YDL140C RPO21
SGTC_1607 st000305 50.6 µM 0.595120468989434 0.316039467258459 no 1080 0.275881473597015 1396 5457690
SGTC_483 fpl-64176 144 µM 0.594239478095904 0.316330636596359 no 1081 0.276175975834253 1373 3423
SGTC_305 1682-2595 20.8 µM 0.594084858064534 0.316381750596015 no 1082 0.276227678938436 1348 226033
SGTC_1488 4013-0813 75.9 µM 0.593934293308923 0.316431527381467 no 1083 0.276278030570835 1321 2910057
SGTC_3060 1327-0027 12.5 µM 0.592678084749456 0.316846960129537 no 1084 0.276698305332149 1280 16000455 YPR107C YTH1
SGTC_1402 3909-7673 35.9 µM 0.591571380811668 0.317213142622338 no 1085 0.277068821482868 1333 5328014
SGTC_1306 1185-0270 9.02 µM 0.588510353805754 0.318226896518276 no 1086 0.278094893136606 1358 1548076
SGTC_1702 st027038 51 µM 0.586746650183119 0.318811621072277 no 1087 0.278686935955708 1376 5521182
SGTC_1226 3909-7979 35.4 µM 0.585778516270485 0.319132780615159 no 1088 0.279012181347837 1400 6615510
SGTC_1328 1441-0025 69.2 µM 0.584353306256667 0.319605813300257 no 1089 0.279491317505414 1274 4562601
SGTC_2841 9004761 38.96 µM 0.584084366691958 0.319695108331935 no 1090 0.279581776109099 1270 2991039
SGTC_1725 st036284 20.55 µM 0.584065284871185 0.319701444397101 no 1091 0.279588194874895 1436 707914
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.583216937647481 0.31998318886665 no 1092 0.27987363519977 1356 16623 A steroid.
SGTC_358 0075-0058 9.45 µM 0.582822001999352 0.320114386326211 no 1093 0.280006565967181 1417 1069125
SGTC_780 0109-0199 192 µM 0.581865618472812 0.320432189714695 no 1094 0.280328600342642 1470 610414
SGTC_733 4069-0007 56.1 µM 0.57931606151272 0.321280043006049 no 1095 0.281187964967101 1408 5717425 YNL287W SEC21
SGTC_268 camptothecin 39.6153 µM 0.578711559084443 0.321481206732505 no 1096 0.281391907580513 1386 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3122 9126309 49.47 µM 0.577335429346829 0.321939344510658 no 1097 0.281856442222436 1399 17591206
SGTC_775 4577-0580 57.3 µM 0.575414363644744 0.322579353806925 no 1098 0.282505546071364 1431 2006902
SGTC_517 1365-0151 113 µM 0.574073953969233 0.323026227377605 no 1099 0.282958878895501 1402 768657
SGTC_1157 4092-0394 27.6 µM 0.572235450375063 0.323639574000818 no 1100 0.283581236884132 1481 3659885
SGTC_2185 6113692 200 µM 0.570969599707427 0.324062155590633 no 1101 0.284010125109571 1375 874150
SGTC_1403 3909-7815 62.9 µM 0.570806153113994 0.324116735854822 no 1102 0.284065525756641 1395 6615483
SGTC_1497 4476-2978 41.3 µM 0.56987284626895 0.324428470510359 no 1103 0.28438197153061 1399 1528379
SGTC_865 0488-0499 301 µM 0.569777564646402 0.32446030253787 no 1104 0.284414287064446 1391 9634651
SGTC_1699 st031318 29.054 µM 0.569650766650452 0.324502665658039 no 1105 0.284457294352378 1440 5340658
SGTC_2011 4012611 177 µM 0.569042552580521 0.324705901110717 no 1106 0.284663631311361 1366 2049887
SGTC_3203 9113543 49.47 µM 0.56878304423616 0.324792632022777 no 1107 0.2847516914026 1434 17018012
SGTC_811 0416-0114 265 µM 0.567331607941161 0.325277895090032 no 1108 0.285244453126183 1391 6612453
SGTC_2650 prasterone 100 µM 0.561066586364048 0.327375891214518 no 1109 0.287376072741921 1369 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_867 0518-0118 155 µM 0.556796879481015 0.32880884310482 no 1110 0.288833108082578 1432 6848158
SGTC_3322 9139058 2.11 µM 0.556635622455666 0.328863011925987 no 1111 0.288888205040074 1456 4908926 YPR165W RHO1
SGTC_3037 9091026 49.47 µM 0.556251718627911 0.328991985844303 no 1112 0.289019394003925 1407 25236398 YIL048W NEO1
SGTC_945 3381-0768 11.3 µM 0.556131255873284 0.329032459952349 no 1113 0.289060564735122 1397 1126236 YIL048W NEO1
SGTC_3163 9099914 49.47 µM 0.555357678695156 0.329292420787299 no 1114 0.289325017046009 1432 16268368
SGTC_2045 5106652 78.05 µM 0.554711348369027 0.329509683586322 no 1115 0.289546056345839 1422 673349
SGTC_316 k060-0003 58.6 µM 0.553337784030584 0.329971595897865 no 1116 0.290016066429687 1426 6152314
SGTC_1067 clotrimazole 1.36 µM 0.553331382465166 0.329973749271049 no 1117 0.290018257772349 1409 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1821 st053465 65.6 µM 0.551193828223128 0.330693099282009 no 1118 0.290750405215487 1366 675086
SGTC_1834 st055981 52.8 µM 0.544625423407446 0.332907467637286 no 1119 0.293005582829908 1505 471719 YDL150W RPC53
SGTC_3338 9144300 39.5675 µM 0.542195673036851 0.333728079346601 no 1120 0.293841857895166 1433 4901274
SGTC_3153 9100258 49.47 µM 0.542041229403788 0.33378026731127 no 1121 0.293895051833764 1373 25236848
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.541708737877508 0.33389263025561 no 1122 0.294009584673237 1399 140250 A respiratory chain inhibitor.
SGTC_1630 st005209 31.3 µM 0.540497515600914 0.334302079370324 no 1123 0.294426986930008 1442 3367314
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.540140819418282 0.334422696782341 no 1124 0.294549960991636 1422 756377
SGTC_3243 9134147 49.47 µM 0.539825743337013 0.33452925450714 no 1125 0.294658605876795 1466 24282180
SGTC_92 0063-0024 660.874 µM 0.538806976610057 0.334873889363123 no 1126 0.295010024598419 1426 3594437
SGTC_1481 3346-2004 36 µM 0.538030437167734 0.335136675490461 no 1127 0.295278017778652 1419 2770522
SGTC_421 streptovitacin 30 mM 0.537956000524772 0.335161869588292 no 1128 0.295303712650895 1449 91467 include heat shock
SGTC_1340 1486-1359 257 µM 0.537377375294034 0.335357738475594 no 1129 0.295503484052599 1442 4309068
SGTC_806 3966-4455 5.86 µM 0.535860646216743 0.335871374738741 no 1130 0.296027432234267 1362 714982
SGTC_896 0964-0007 44.5 µM 0.534546941565585 0.336316505250405 no 1131 0.296481590739673 1416 6756758
SGTC_235 0330-0087 5 mM 0.534239848221538 0.336420592675278 no 1132 0.296587801462014 1418 46494818 YHR062C RPP1
SGTC_2429 5902844 64.44 µM 0.530529712330521 0.337679109449972 no 1133 0.297872357011885 1499 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2614 arthonioic acid 13.39 µM 0.53028115405465 0.337763488114527 no 1134 0.297958505622192 1371 6710684
SGTC_1301 naphtanilide LB 4.81 µM 0.528628457376451 0.338324740156702 no 1135 0.298531607657219 1546 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2152 5568786 200 µM 0.527452504312334 0.338724310080437 no 1136 0.298939695424328 1419 5399883
SGTC_1785 bathophenanthroline 24 µM 0.526834254516597 0.338934454264289 no 1137 0.299154346533086 1400 72812 An iron chelator.
SGTC_850 0388-0143 75.9 µM 0.52640765986007 0.339079483766338 no 1138 0.299302497370322 1428 67273
SGTC_1819 st053448 58.6 µM 0.526208613300636 0.339147161841124 no 1139 0.299371635065797 1456 2857616
SGTC_1250 0485-0349 40.2 µM 0.524541029914822 0.339714362711554 no 1140 0.299951145005213 1450 6842794 YDL195W SEC31
SGTC_2544 sphondin 68.51 µM 0.522863793345762 0.340285213295983 no 1141 0.300534521106732 1495 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_856 0433-0016 11.3 µM 0.522827373565212 0.340297612902951 no 1142 0.300547194309722 1461 3911780
SGTC_1023 4482-3888 16 µM 0.521968495004274 0.340590079755352 no 1143 0.30084613320323 1538 3303168
SGTC_1269 0831-0796 3.05 µM 0.521682322036442 0.34068754918552 no 1144 0.300945767554407 1516 927758
SGTC_1125 tnp00248 1.32998 µM 0.521221345369915 0.340844578462722 no 1145 0.301106293065846 1567 24207736
SGTC_2329 6138490 200 µM 0.521180650629375 0.340858442237317 no 1146 0.301120466013965 1474 720019
SGTC_122 0236-0016 402.397 µM 0.519303321738788 0.341498238977249 no 1147 0.301774618668045 1479 6808838
SGTC_36 0335-0881 14.2 µM 0.51838755361355 0.341810499738776 no 1148 0.302093948441503 1458 23828853
SGTC_2441 5730946 39.09 µM 0.518207339668607 0.3418719622673 no 1149 0.302156807186889 1515 1774275
SGTC_2692 st077426 47.7 µM 0.518106428035983 0.341906380325301 no 1150 0.302192007796385 1489 25238571
SGTC_2418 pentamidine 31.67 µM 0.518068480328832 0.341919323537681 no 1151 0.302205245422607 1398 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2047 4141938 200 µM 0.517738482860061 0.342031886979071 no 1152 0.302320372258269 1475 3807862
SGTC_3293 9120939 62.045 µM 0.517440259703498 0.34213362415563 no 1153 0.302424430851738 1497 934087
SGTC_952 1185-0122 232 µM 0.516290640401304 0.342525917596506 no 1154 0.302825716135301 1391 678600
SGTC_2904 7225135 42.03 µM 0.514674055884772 0.343077844586427 no 1155 0.303390402935024 1514 4446116
SGTC_1268 0828-0275 2.46 µM 0.51441158654788 0.343167487320596 no 1156 0.303482130099795 1501 745337
SGTC_1754 st042065 16.137 µM 0.51214984684637 0.343940318168395 no 1157 0.304273070279153 1404 1126236 YIL048W NEO1
SGTC_2836 9010338 19.48 µM 0.510743122215158 0.344421321813006 no 1158 0.304765470566156 1341 2994051
SGTC_431 k089-0097 107 µM 0.51053856059547 0.344491288882588 no 1159 0.304837103409872 1402 5499420
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.509137095669885 0.344970780812767 no 1160 0.305328065759909 1445 4330530
SGTC_2439 5492030 7.2 µM 0.508959925734473 0.345031414815583 no 1161 0.30539015704434 1480 5722370
SGTC_471 1-acyl-paf 4 µM 0.508192946352584 0.345293948969326 no 1162 0.305659018543092 1391 16759367
SGTC_129 0088-0017 176.636 µM 0.507659979436355 0.345476425393751 no 1163 0.305845909656035 1491 182446
SGTC_2969 9091408 28.7 µM 0.506885223090039 0.345741749372354 no 1164 0.306117677256302 1411 4286311
SGTC_2934 9036370 36.88 µM 0.505457681594983 0.346230825309599 no 1165 0.306618707087942 1585 6462800
SGTC_1498 4478-3555 97.6 µM 0.50286114064117 0.347121057881069 no 1166 0.307530951853387 1503 3437919
SGTC_3043 9092303 49.47 µM 0.502194811403414 0.347349647375459 no 1167 0.307765246188899 1403 25236084
SGTC_651 3253-0966 34.4 µM 0.500668180926343 0.347873579249186 no 1168 0.308302334699218 1451 781462
SGTC_1833 st055984 71 µM 0.499640442276786 0.348226457706248 no 1169 0.308664137910161 1474 676288
SGTC_1085 doxorubicin 7.67 µM 0.499633539944705 0.348228828096123 no 1170 0.308666568422909 1568 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2826 7992541 19.48 µM 0.49734703829102 0.349014381289187 no 1171 0.309472173211288 1531 2985066
SGTC_1501 4491-0275 38.4 µM 0.497332387800474 0.349019416720104 no 1172 0.309477337988105 1488 5104718
SGTC_855 0428-0020 25 µM 0.497056249776942 0.349114331411214 no 1173 0.309574692706116 1476 6812414
SGTC_2069 5228469 200 µM 0.49439644173163 0.350029048308652 no 1174 0.310513113236599 1438 2835210
SGTC_2611 pyromycin 23.93 µM 0.494064530574779 0.350143254894196 no 1175 0.310630303278856 1456 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1995 st072814 61.1 µM 0.493884357543905 0.350205255915746 no 1176 0.310693926197526 1441 5769371
SGTC_414 piperonyl butoxide 100 µM 0.492861162676671 0.350557432717252 no 1177 0.311055345333906 1454 5794 A potent inhibitor of cytochrome P450.
SGTC_2580 diallyl disulphide 81.36 µM 0.492782353204062 0.350584563741529 no 1178 0.3110831904622 1508 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2596 sinensetin 100 µM 0.492387138392375 0.350720632262113 no 1179 0.311222844895838 1464 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.490628635949151 0.351326299097318 no 1180 0.311844564509239 1535 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1293 1000-1278 195 µM 0.488573730497135 0.352034532200873 no 1181 0.312571757417603 1550 678847
SGTC_68 0986-0284 82.829 µM 0.488549995624074 0.352042715544693 no 1182 0.312580161020445 1433 423278 YIL048W NEO1
SGTC_3273 9137859 49.47 µM 0.48772139295302 0.352328445300317 no 1183 0.312873598315272 1543 2377234
SGTC_2159 5658611 73.75 µM 0.485347578855804 0.353147476387056 no 1184 0.31371490532696 1508 793844
SGTC_258 haloperidol 50.781 µM 0.483800001699449 0.353681799856053 no 1185 0.314263906936543 1441 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1158 4092-0494 91.8 µM 0.482789283836221 0.354030920617965 no 1186 0.314622680228882 1592 1148199
SGTC_26 0302-0163 425.158 µM 0.48273629011699 0.354049229024172 no 1187 0.314641496178873 1519 3100915
SGTC_330 1488-0319 80.1 µM 0.4802246096801 0.35491735715003 no 1188 0.315533844773992 1520 6846614
SGTC_3057 9095946 49.47 µM 0.479402156948396 0.35520179078829 no 1189 0.315826279655812 1534 24540043
SGTC_2977 9011197 71.43 µM 0.479095843371083 0.355307745635886 no 1190 0.315935223330361 1563 2704722
SGTC_1766 st045414 44.774 µM 0.47799152648244 0.355689825190662 no 1191 0.316328118024018 1517 253960
SGTC_2937 9044753 11.33 µM 0.476559272328061 0.356185582850489 no 1192 0.316837995427369 1465 6465530 YGL099W LSG1
SGTC_3287 9117173 37.0625 µM 0.474689539803395 0.356833134305593 no 1193 0.317504137340714 1502 2789709
SGTC_2654 protoveratrine a 100 µM 0.47436566519573 0.356945345002592 no 1194 0.317619586432396 1509 5702278 A heart drug and vasodilator.
SGTC_2415 st077333 57.7 µM 0.474043094438461 0.357057116265955 no 1195 0.317734588381974 1757 2766255
SGTC_1782 st039423 80.636 µM 0.473780787964917 0.357148014907841 no 1196 0.317828118057109 1468 2068169
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.473117394687236 0.357377940749829 no 1197 0.318064713673736 1543 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2320 7373003 200 µM 0.472025529682989 0.357756483571051 no 1198 0.318454283087125 1446 5415828
SGTC_70 0141-0289 43.283 µM 0.471622969385329 0.357896084057385 no 1199 0.318597964335603 1619 352408
SGTC_2986 9022445 71.43 µM 0.470229103912778 0.358379597630001 no 1200 0.319095671469672 1630 6459286
SGTC_620 0109-0052 432 µM 0.469902865153736 0.358492798391569 no 1201 0.319212208601625 1594 493037
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.469591269387375 0.358600929829139 no 1202 0.319323531729817 1563 65057 A dermal irritant. YDR527W RBA50
SGTC_2962 9082311 13.18 µM 0.469477670342734 0.358640354327519 no 1203 0.31936412106101 1461 16459453
SGTC_2134 5324836 1.464 µM 0.467516734369912 0.359321133397759 no 1204 0.320065111117953 1578 699272
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.465767949787732 0.359928636815891 no 1205 0.320690804302588 1573 279621
SGTC_3268 9137683 49.47 µM 0.463567230917943 0.360693638834048 no 1206 0.32147891823901 1542 1953228
SGTC_336 4111-0029 111 µM 0.462887328840466 0.360930095654888 no 1207 0.321722565244583 1502 3131175
SGTC_2078 5212016 200 µM 0.462492684189733 0.361067369838944 no 1208 0.321864023715497 1585 1899708
SGTC_137 0438-0332 85.389 µM 0.462475640448286 0.361073298779917 no 1209 0.321870133544171 1499 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2367 9070478 135.38 µM 0.460960156672208 0.36160061758733 no 1210 0.322413595482638 1533 572802
SGTC_999 SEC7.066 22.7 µM 0.459867467425382 0.361980986516927 no 1211 0.322805676354403 1591 740511 YDR170C SEC7
SGTC_2701 st077767 14.721 µM 0.456878905884968 0.363022010729203 no 1212 0.323879043277486 1519 5721188
SGTC_2722 naftopidil 47.16 µM 0.456197570201704 0.363259486686343 no 1213 0.324123956261889 1581 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2945 9067681 61.76 µM 0.455597961335887 0.363468520686882 no 1214 0.324339554705654 1564 16456930
SGTC_1878 temozolomide 1 mM 0.453865562298872 0.364072693135514 no 1215 0.324962795737817 1656 5394 DNA alkylating agent.
SGTC_335 4077-0256 27.6 µM 0.453408188789261 0.364232258153993 no 1216 0.325127420483825 1612 3121989
SGTC_367 0335-0881 7.1 µM 0.453058398148532 0.364354306357661 no 1217 0.325253345429441 1612 23828853
SGTC_2649 anisomycin 9.56 µM 0.451878849393162 0.364765973323941 no 1218 0.325678131095501 1529 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2726 cimetidine 79.27 µM 0.45136169093596 0.364946512787613 no 1219 0.325864444522118 1560 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2019 4016004 108 µM 0.449203863588639 0.365700130739 no 1220 0.326642300321464 1504 45595336
SGTC_2115 tiliquinol 12.7705 µM 0.446896042634406 0.36650670768525 no 1221 0.327475060714727 1580 71208 A bioactive hydroxyquinoline.
SGTC_599 1935-0052 86.5 µM 0.445630664640871 0.366949204399814 no 1222 0.327932028130746 1537 9557311
SGTC_234 nsc-17383 10.7 µM 0.444438747666882 0.367366173892291 no 1223 0.328362702235656 1640 408974
SGTC_3105 9121040 49.47 µM 0.443998800750066 0.367520120512574 no 1224 0.328521725479094 1500 41448907
SGTC_2224 6650123 117.647 µM 0.443483299023754 0.36770053242962 no 1225 0.328708098294308 1561 2908370
SGTC_1739 st037196 92.5 µM 0.44291767740893 0.367898518568954 no 1226 0.328912640318021 1699 612214
SGTC_2617 dihydrotanshinone i 20.83 µM 0.442099470457386 0.368184979973357 no 1227 0.32920861378951 1533 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3301 9125354 19.7965 µM 0.441979602056587 0.36822695310799 no 1228 0.329251983291351 1529 41905162
SGTC_454 lyso-paf C-16 6.67 µM 0.441841169025431 0.368275428793101 no 1229 0.329302072508124 1467 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1008 4106-0037 6 µM 0.440670118602924 0.368685584349718 no 1230 0.329725916130143 1554 2905394
SGTC_2710 st078562 53.7235 µM 0.440571306167675 0.368720199847539 no 1231 0.329761689781258 1506 17250908
SGTC_181 1447-1644 8.07 µM 0.440254833995518 0.368831072026605 no 1232 0.329876274556175 1630 534600
SGTC_295 k015-0027 31 µM 0.439634514569743 0.369048425062294 no 1233 0.33010091932377 1554 3887424
SGTC_49 0717-0965 32.132 µM 0.438188678776878 0.369555192321075 no 1234 0.330624757356307 1642 5889349 YGL099W LSG1
SGTC_1830 st055982 50.3 µM 0.437543007951546 0.369781574030925 no 1235 0.330858796415245 1670 455313 An antimicrobial agent.
SGTC_2143 5623677 140.463 µM 0.435396435075261 0.370534518215721 no 1236 0.33163734877075 1579 5375313
SGTC_2794 7785382 27.27 µM 0.435093940726666 0.370640662818897 no 1237 0.331747120703178 1641 2205081
SGTC_1697 st025554 27.742 µM 0.434780652777047 0.370750605253502 no 1238 0.331860824747687 1558 1269519
SGTC_986 1493-0483 84 µM 0.433600853376668 0.371164728009036 no 1239 0.332289157485368 1636 40079
SGTC_1205 4161-2785 76 µM 0.432146191602147 0.371675535913455 no 1240 0.332817582201578 1500 3498106
SGTC_1270 0831-1170 17.3 µM 0.431719201327753 0.37182551750254 no 1241 0.332972755069108 1559 6764716
SGTC_707 0865-0008 204 µM 0.431596309605922 0.371868687187376 no 1242 0.333017420547811 1650 723043
SGTC_1872 amphotericin b 148 nM 0.43118509285612 0.372013152058387 no 1243 0.333166896113576 1650 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_223 busulfan 5 mM 0.431085302651582 0.372048212149165 no 1244 0.333203173432199 1620 2478 A DNA alkylator.
SGTC_925 2064-1272 59.6 µM 0.429533602712154 0.372593519635365 no 1245 0.333767472637435 1563 6815817
SGTC_694 1315-0438 43.2 µM 0.428315085436192 0.373021917263608 no 1246 0.334210868701693 1634 6793154
SGTC_322 k048-0136 19.3 µM 0.425257157364329 0.374097692414708 no 1247 0.335324610724552 1593 6823282
SGTC_154 3389-1638 511.116 µM 0.425255463676332 0.374098288524608 no 1248 0.335325227992792 1469 5238686
SGTC_146 3448-8650 53.125 µM 0.424148039307537 0.374488121652578 no 1249 0.335728926304423 1616 2891488 YIL048W NEO1
SGTC_3028 9087778 49.47 µM 0.42364786524595 0.374664233937494 no 1250 0.335911320979269 1515 17217395
SGTC_2540 epiandrosterone 100 µM 0.419876921831798 0.37599282988159 no 1251 0.337287683870763 1606 441302 A steroid.
SGTC_2496 diffractaic acid 79.83 µM 0.416850381673338 0.377060219433306 no 1252 0.338393924210195 1712 94870 An apoptosis inducer which activates caspases.
SGTC_313 3474-0040 5.03 µM 0.416676276184256 0.377121651019599 no 1253 0.338457604621738 1566 1043375 YIL048W NEO1
SGTC_74 000s-0487 160.283 µM 0.415796679820647 0.377432056357188 no 1254 0.33877939430091 1504 677548
SGTC_186 3455-3465 67.277 µM 0.415302073510101 0.37760663535093 no 1255 0.338960391748605 1588 755278
SGTC_790 1575-0012 79.1 µM 0.414022703715973 0.378058324750846 no 1256 0.339428739861034 1655 378741 YLR208W SEC13
SGTC_1003 4049-0218 100 µM 0.41398272277429 0.378072442958876 no 1257 0.33944337997402 1659 295161
SGTC_2821 7996764 71.43 µM 0.412979435601538 0.378426780449549 no 1258 0.3398108402394 1641 2987135
SGTC_3023 9089636 49.47 µM 0.409780115864626 0.379557386704333 no 1259 0.340983626875873 1681 17249241
SGTC_444 curcumin 90.4 µM 0.40911749587476 0.379791678852966 no 1260 0.3412267186267 1632 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2424 5537928 59.2 µM 0.408731726942173 0.379928101095032 no 1261 0.341368273913853 1569 5382802
SGTC_584 0986-0246 15.4 µM 0.408405033757393 0.380043643642179 no 1262 0.341488169213619 1669 53315 YDR232W HEM1
SGTC_2753 fluvastatin 17.09 µM 0.408198319366347 0.380116758465274 no 1263 0.341564040964229 1625 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2196 6573537 42.6665 µM 0.407451123263255 0.380381077235945 no 1264 0.341838342670203 1700 2903087
SGTC_147 4466-0538 29.23 µM 0.406536167199242 0.380704816750603 no 1265 0.342174344152218 1661 6742687 YHR072W ERG7
SGTC_1832 st054113 55 µM 0.404516682093607 0.381419667939012 no 1266 0.342916406557638 1670 1251267
SGTC_479 n-linoleoylglycine 10 µM 0.40388155504835 0.38164457204954 no 1267 0.343149910284807 1612 6433346 An anti-infammatory.
SGTC_2795 7780010 54.55 µM 0.402520459317356 0.382126682596764 no 1268 0.343650517211133 1632 953673
SGTC_615 k087-0205 167 µM 0.401041795077478 0.382650643992896 no 1269 0.344194676368042 1551 9642773
SGTC_2997 9067075 71.4286 µM 0.399827362265008 0.383081136324 no 1270 0.344641837907467 1681 27209819
SGTC_2745 rifampicin 24.3 µM 0.398555561898494 0.383532119150291 no 1271 0.345110355328392 1744 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_900 1112-0045 141 µM 0.398240427802024 0.383643890723148 no 1272 0.345226484048673 1583 56211 YIL048W NEO1
SGTC_1476 4112-3294 3.34 µM 0.397425441318527 0.383932994519738 no 1273 0.345526878800771 1714 704369
SGTC_3348 9149464 3.537 µM 0.396987411132518 0.384088405628228 no 1274 0.345688371964736 1617 1951442
SGTC_2776 terbinafine 19.92 µM 0.396168798178098 0.384378895713997 no 1275 0.345990253820799 1617 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3131 9127911 49.47 µM 0.395879853445637 0.384481445131665 no 1276 0.34609683205013 1674 45595681
SGTC_393 acivicin 6.25 µM 0.395768666428106 0.384520908686987 no 1277 0.346137847001597 1627 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1142 3253-1408 9.78 µM 0.395659417728028 0.384559685441888 no 1278 0.346178148699519 1686 256655
SGTC_3321 9137793 26.8275 µM 0.395342711904167 0.384672103595129 no 1279 0.346294990894051 1627 4904192
SGTC_1924 st058459 75.1 µM 0.393515818343446 0.385320768243745 no 1280 0.346969271546414 1633 688683
SGTC_448 monastrol 171 µM 0.392367790248795 0.385728556356817 no 1281 0.347393240758186 1659 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_256 clotrimazole 625 nM 0.389525785410423 0.386738600179868 no 1282 0.348443619933534 1643 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3318 9139014 38.6185 µM 0.387729496127483 0.387377394818106 no 1283 0.349108112663605 1641 16643984
SGTC_2938 9059746 27.26 µM 0.387614829846039 0.387418182705243 no 1284 0.349150546353619 1674 6471769
SGTC_311 1315-0136 58 µM 0.386671692189879 0.387753712850678 no 1285 0.349499637737142 1729 6759207
SGTC_3265 9137266 49.47 µM 0.386024344850891 0.387984061326698 no 1286 0.349739319499222 1790 17224265
SGTC_2960 9079389 5.97 µM 0.385324144971388 0.388233260933814 no 1287 0.349998637464589 1773 16457355
SGTC_1054 3429-0080 167 µM 0.384864604655694 0.388396835348268 no 1288 0.350168865563615 1715 1162877
SGTC_3251 9135047 49.47 µM 0.384834784305542 0.388407450653608 no 1289 0.350179912994199 1753 17682963
SGTC_895 0964-0006 13.7 µM 0.382607527546049 0.389200533923023 no 1290 0.351005394023538 1709 6738897
SGTC_1765 st044815 90.4 µM 0.381469357476112 0.389605992890658 no 1291 0.351427502268072 1578 645695
SGTC_2015 5119600 184 µM 0.378237976279167 0.390757785977818 no 1292 0.352626908168667 1767 2828786
SGTC_352 k048-0007 5.11 µM 0.377910409682738 0.390874597479815 no 1293 0.352748574559471 1650 6811911
SGTC_2246 7293507 91.5585 µM 0.377097620039559 0.391164483886208 no 1294 0.353050529902949 1819 887656
SGTC_1073 triclabendazole 3.09 µM 0.376031752215845 0.391544723802717 no 1295 0.353446645289514 1691 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1331 1472-0049 76.2 µM 0.374396098889071 0.392128431649411 no 1296 0.354054822447512 1621 24051409
SGTC_1777 st045864 34.765 µM 0.37404836640166 0.392252556637523 no 1297 0.354184166223851 1669 4691462
SGTC_1959 st077091 55.8 µM 0.372049625928259 0.392966230095779 no 1298 0.354927950502392 1652 821356 YKL052C ASK1
SGTC_3102 9121669 49.47 µM 0.370899373758424 0.393377104296368 no 1299 0.355356240804964 1713 41905072
SGTC_341 1486-1430 230 µM 0.369352172338174 0.393929957450295 no 1300 0.355932621216517 1616 2054753 YPL210C SRP72
SGTC_2168 5727979 200 µM 0.369072919742184 0.394029764089342 no 1301 0.356036686585137 1609 695210
SGTC_1014 4130-3005 69.3 µM 0.367465013308019 0.39460457520959 no 1302 0.356636092257456 1638 743608
SGTC_1911 st060208 74.3 µM 0.366352970760886 0.395002254104225 no 1303 0.357050853922383 1755 688783
SGTC_629 3448-6466 76.7 µM 0.366197393742248 0.395057898925032 no 1304 0.357108893410997 1677 573744
SGTC_770 0389-1121 67.2 µM 0.365393837118982 0.395345338950126 no 1305 0.357408720482707 1799 6753108
SGTC_1527 coumarin 137 µM 0.36441616080255 0.395695140066558 no 1306 0.3577736346813 1735 323 A hepatotoxic, DNA x-linker.
SGTC_1452 4194-0072 190 µM 0.363890553934894 0.395883230788027 no 1307 0.357969869335093 1821 1343545
SGTC_2706 st078239 82.5 µM 0.362634169324809 0.396332931697939 no 1308 0.358439090937374 1689 15434492
SGTC_2847 9005661 71.43 µM 0.362633716536543 0.396333093790489 no 1309 0.358439260078663 1688 2991449
SGTC_1513 0337-0559 19 µM 0.361513365591421 0.396734220259724 no 1310 0.358857857669977 1604 775073
SGTC_1649 st011737 51.3 µM 0.361022895181978 0.396909860965538 no 1311 0.359041165904377 1675 1761035
SGTC_1744 st037937 38.9 µM 0.359816943624958 0.397341809076893 no 1312 0.359492015757015 1739 1016152
SGTC_3319 9138450 16.7555 µM 0.359708404528829 0.39738069182966 no 1313 0.359532603142525 1676 2029690
SGTC_194 1486-1323 56.904 µM 0.359475214502044 0.397464232643826 no 1314 0.359619808172884 1656 5178754
SGTC_11 0438-0307 1.3 µM 0.359381353231135 0.397497859967985 no 1315 0.359654911115831 1789 4011476
SGTC_2490 carminic acid 95.39 µM 0.357165966804649 0.398291778782417 no 1316 0.360483781181802 1696 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1084 voriconazole 435 nM 0.355036442149091 0.39905532478227 no 1317 0.36128114522014 1811 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_815 1582-0027 36.9 µM 0.351373732154446 0.400369500289877 no 1318 0.362653993159328 1744 3128206
SGTC_3160 9100216 49.47 µM 0.350021511261523 0.400854961451457 no 1319 0.363161276961532 1718 17191039
SGTC_209 4077-0173 175.592 µM 0.348606030576958 0.401363297587234 no 1320 0.363692549846564 1715 15993494
SGTC_2432 5630864 12.22 µM 0.348393292794599 0.401439711744769 no 1321 0.363772419485848 1663 5714970
SGTC_2467 5474540 200 µM 0.347888312063489 0.401621112935123 no 1322 0.363962031645439 1668 5413519
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.34303698573528 0.403364900455936 no 1323 0.365785317922479 1668 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3238 9133470 49.47 µM 0.342707540096359 0.403483388336804 no 1324 0.365909244853789 1807 3534688
SGTC_1264 0783-0040 158 µM 0.341907959491974 0.403771001018266 no 1325 0.366210079718259 1641 2855798
SGTC_136 0097-0015 404.482 µM 0.337158501590065 0.405480469605538 no 1326 0.367998709270876 1812 4861337
SGTC_1547 harmine 94.2 µM 0.336557859093048 0.405696787586057 no 1327 0.368225114093464 1716 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3345 9148410 3.559 µM 0.335638815183713 0.406027831753823 no 1328 0.368571624998518 1821 4903596
SGTC_2831 7999036 19.48 µM 0.334831626204708 0.4063186406619 no 1329 0.36887605096668 1887 2988270
SGTC_1074 carmofur 3.8 µM 0.33368094201443 0.406733291159385 no 1330 0.369310166098047 1738 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1155 4088-0394 48.2 µM 0.332738096666401 0.407073124646653 no 1331 0.369665994789479 1695 2326248
SGTC_860 0443-0016 25.1 µM 0.332654642581238 0.407103207707926 no 1332 0.369697495642695 1744 5337942
SGTC_523 1934-0222 13.7 µM 0.332473764930528 0.407168411351423 no 1333 0.369765773316614 1699 1361595
SGTC_1010 4112-3296 15.2 µM 0.331344458162391 0.407575567380181 no 1334 0.370192156670889 1886 704384
SGTC_2003 4023581 200 µM 0.331164701438936 0.40764038541927 no 1335 0.37026004071851 1718 16641307
SGTC_1746 st038117 42 µM 0.329218509776467 0.408342319453367 no 1336 0.370995266638669 1729 2898218
SGTC_1341 1486-1360 280 µM 0.32903524906152 0.408408431388249 no 1337 0.371064522586108 1705 3976547
SGTC_2142 5622915 118.518 µM 0.328946769530676 0.408440351617402 no 1338 0.371097961327836 1715 5322196
SGTC_2645 abamectin 100 µM 0.328580747321317 0.408572405704674 no 1339 0.371236301085338 1813 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2483 5729050 27.16 µM 0.328082625136717 0.408752135710558 no 1340 0.371424595355711 1863 2865180
SGTC_1410 3909-8106 77.9 µM 0.326408826710824 0.409356207832009 no 1341 0.372057530088553 1814 1039210
SGTC_2387 9077560 195.08 µM 0.32376276077643 0.410311608964647 no 1342 0.373058825730315 1705 5303272
SGTC_2128 5255449 168.493 µM 0.323162304892594 0.41052848675725 no 1343 0.373286163440356 1715 736008
SGTC_1387 3342-1166 1.8 µM 0.321974482074277 0.410957595303921 no 1344 0.373736013162346 1773 3418228
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.321942055908879 0.410969310959093 no 1345 0.373748295945941 1856 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1654 st012436 41.8 µM 0.320756765891908 0.411397613651017 no 1346 0.374197362658064 1838 4323132
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.319893648420125 0.411709566284681 no 1347 0.374524476457823 1790 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.318986390716146 0.412037532488806 no 1348 0.374868416384571 1916 4114 Related to psoralen; DNA damaging agent.
SGTC_2067 5224629 34.075 µM 0.318864686638275 0.412081532192061 no 1349 0.374914561781923 1701 2835000
SGTC_3078 9116413 49.47 µM 0.318411934882963 0.41224522533752 no 1350 0.375086243149781 1714 17177322
SGTC_2178 5812956 200 µM 0.317785575298052 0.412471711847057 no 1351 0.375323796603415 1756 5403383
SGTC_2390 9097792 176.6 µM 0.315928999027608 0.41314320562786 no 1352 0.376028200158146 1678 4497149
SGTC_521 r062-0005 13.8 µM 0.315551969340001 0.413279602316664 no 1353 0.376171299539889 1720 2832033
SGTC_1504 k297-0033 30 µM 0.315302075306887 0.413370011360961 no 1354 0.376266154721243 1687 4388117
SGTC_1864 st057645 30.4 µM 0.314888122867783 0.413519785123495 no 1355 0.376423299900304 1842 688666
SGTC_2727 riluzole 51.77 µM 0.31410124919348 0.413804521664897 no 1356 0.376722070397219 1821 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2304 7443016 91.4 µM 0.313971064745195 0.413851634323829 no 1357 0.376771507657177 1734 939854
SGTC_2873 9040596 71.43 µM 0.307058032439103 0.416355167476178 no 1358 0.379399600413192 1713 6463863
SGTC_1546 5-methoxyflavanone 78.7 µM 0.304300197547534 0.417354862506622 no 1359 0.380449597333512 1921 147795
SGTC_2221 6807166 181.081 µM 0.304289366186734 0.417358789853786 no 1360 0.380453722925467 1831 674925
SGTC_1038 k292-0204 154 µM 0.302679145687689 0.417942731817374 no 1361 0.381067196031621 1726 4454212
SGTC_583 1488-1091 88.9 µM 0.302669423491648 0.417946258095459 no 1362 0.381070900971859 1919 4303273
SGTC_2830 7992007 71.43 µM 0.30243736033279 0.418030430257553 no 1363 0.381159338973347 1701 1952075
SGTC_3316 9136639 10.545 µM 0.302219068611999 0.418109610776848 no 1364 0.381242534420729 1837 4903665
SGTC_2215 7188065 200 µM 0.301957729230681 0.418204410253246 no 1365 0.381342143432292 1865 940217
SGTC_2703 st077852 53.4 µM 0.301538373982297 0.418356539076816 no 1366 0.381501996317639 1791 6281836
SGTC_618 k072-0232 33.2 µM 0.300989592493604 0.418555638094078 no 1367 0.381711215371339 1791 5872756 YGL099W LSG1
SGTC_3120 9124077 49.47 µM 0.300883060364141 0.418594290582947 no 1368 0.381751833998353 1813 18774327 YGL155W CDC43
SGTC_1136 pergolide 1.05886 µM 0.298477520514068 0.419467288436262 no 1369 0.382669365337391 1774 47811 A dopamine receptor agonist.
SGTC_1690 st023502 41.2 µM 0.297851614598742 0.41969450201998 no 1370 0.382908209299868 1886 24207482
SGTC_1991 st073000 8.92 µM 0.297354466626631 0.419874993550526 no 1371 0.383097951324584 1854 4301969 YIL048W NEO1
SGTC_1262 0737-0114 49.6 µM 0.296747222738253 0.420095478701131 no 1372 0.383329750727265 1925 765919
SGTC_2079 5212404 121 µM 0.296287630705346 0.420262369381927 no 1373 0.383505215689498 1912 758462
SGTC_1646 st011709 75.6 µM 0.295375769436807 0.420593534045217 no 1374 0.383853420589102 1903 5757843
SGTC_1252 0493-0875 34.8 µM 0.295272594103629 0.420631008228375 no 1375 0.383892825209764 1756 3960963
SGTC_1319 1306-0155 43.7 µM 0.294690759174695 0.420842349218025 no 1376 0.38411506148958 1818 3122360
SGTC_3108 9121785 49.47 µM 0.294401178578655 0.420947542626788 no 1377 0.384225683209822 1904 17140271
SGTC_175 3793-3120 23.7 µM 0.294004017349882 0.421091825088089 no 1378 0.384377416785684 1768 5322297
SGTC_1950 st077106 7.18 µM 0.293386134399304 0.421316313360732 no 1379 0.384613511272467 1745 13831864
SGTC_2571 chrysanthemic acid 100 µM 0.29274822979979 0.421548102703965 no 1380 0.384857300981705 1707 2743 An insecticide.
SGTC_530 4358-1714 28 µM 0.292170862116309 0.421757918763536 no 1381 0.385077994392684 1840 1564641
SGTC_3013 9080133 71.4286 µM 0.289829711736836 0.422608922468678 no 1382 0.385973258151076 1839 17050193
SGTC_60 0986-0278 202 µM 0.289779809847707 0.422627065657463 no 1383 0.385992347431198 1629 3110598
SGTC_2227 7312221 64.1025 µM 0.288923289373544 0.422938502523328 no 1384 0.386320040531672 1867 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2922 7999257 32.47 µM 0.288681111049719 0.4230265690077 no 1385 0.386412709386615 1783 2988377
SGTC_2990 9074105 71.4286 µM 0.288183226651313 0.423207633328097 no 1386 0.386603243798425 1813 6502001
SGTC_2146 5545642 200 µM 0.286704047199923 0.42374565819429 no 1387 0.387169469208098 1868 825326
SGTC_63 0099-0242 26.702 µM 0.286634029334515 0.423771129463203 no 1388 0.387196277797265 1935 3898502 YLR359W ADE13
SGTC_1470 k295-0292 231 µM 0.28650146082955 0.423819356427788 no 1389 0.38724703738192 1885 5045612
SGTC_1191 1487-1166 10.6 µM 0.286444449905996 0.423840096725874 no 1390 0.38726886707215 1872 3955771
SGTC_3070 9117005 49.47 µM 0.285329816414703 0.424245637309757 no 1391 0.387695735833408 1873 8779016
SGTC_989 1501-0895 10.3 µM 0.284921310055984 0.424394285564563 no 1392 0.387852214650567 1945 2830112
SGTC_692 k241-0027 77.8 µM 0.281091504578028 0.425788404443315 no 1393 0.389320108479802 1908 3600480
SGTC_3317 9138495 8.753 µM 0.280302864113979 0.426075599737356 no 1394 0.38962257679222 1824 17020139
SGTC_744 1594-0068 283 µM 0.278663182909371 0.426672839673148 no 1395 0.390251659725735 1792 668392
SGTC_1854 st056233 32.9 µM 0.277764553675671 0.427000229154884 no 1396 0.390596551436562 1957 5393174
SGTC_1077 5-fluorocytosine 377 nM 0.277423903178647 0.427124348434902 no 1397 0.390727314786534 1830 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3079 9117512 49.47 µM 0.275846413631605 0.427699215776588 no 1398 0.391333016615591 1865 7185044
SGTC_948 3448-0295 75.3 µM 0.275487201505689 0.427830141044133 no 1399 0.39147097863994 1793 678569
SGTC_2053 5265679 138 µM 0.275315105427792 0.427892869262702 no 1400 0.391537080142702 1780 764595
SGTC_2646 retinol 96.75 µM 0.274347154674858 0.428245716709248 no 1401 0.39190892494407 1841 445354 A vitamin A analog and teratogen.
SGTC_556 4058-0063 51.5 µM 0.274326508257525 0.428253243581364 no 1402 0.39191685748122 1826 6615692
SGTC_1285 0929-0069 65.5 µM 0.273613812912879 0.42851308027014 no 1403 0.392190708892656 1836 1206237
SGTC_2908 7930301 100 µM 0.271823717508611 0.429165855266812 no 1404 0.392878783846574 1798 2223178
SGTC_504 lovastatin 124 µM 0.271280852775081 0.429363854331451 no 1405 0.39308751588426 1770 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_95 0471-0001 561.058 µM 0.271269804453547 0.429367884170669 no 1406 0.393091764294424 1731 4015405
SGTC_937 3122-0005 46.7 µM 0.271031331538127 0.429454868181636 no 1407 0.393183467367506 1954 759535
SGTC_389 tpck 16.7 µM 0.270007759036024 0.429828259459171 no 1408 0.393577142193641 1823 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1714 st033236 13.627 µM 0.269816631685934 0.429897988193154 no 1409 0.393650663491353 1906 2916566
SGTC_21 0849-0113 22.993 µM 0.269764348129059 0.42991706311385 no 1410 0.393670776160736 1798 1560156
SGTC_1562 morin hydrate 59.1 µM 0.268959667390888 0.430210660175569 no 1411 0.393980360047915 1831 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1046 2001-0062 216 µM 0.268827375659911 0.430258932039558 no 1412 0.394031262910953 1794 739778
SGTC_605 1315-0399 119 µM 0.268824179540607 0.430260098282841 no 1413 0.394032492727702 1883 24020461
SGTC_3029 9088683 49.47 µM 0.266802103162062 0.43099806241689 no 1414 0.394810767424001 1852 25236615
SGTC_3329 9141233 27.5565 µM 0.265781031117408 0.431370798104191 no 1415 0.3952039264615 1926 4909101 YNL103W MET4
SGTC_6 0844-0013 19.835 µM 0.263630171779743 0.432156154866461 no 1416 0.396032453517571 1922 1584900
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.262408023514285 0.432602525208648 no 1417 0.396503443746551 1817 688667
SGTC_678 1218-2179 85.9 µM 0.26156316694373 0.432911146044888 no 1418 0.396829122047421 1871 6820081 YOR116C RPO31
SGTC_3259 9138485 49.47 µM 0.261448253790442 0.432953126269082 no 1419 0.39687342474206 1937 17646153
SGTC_2474 5321570 43.32 µM 0.260305318024518 0.433370706179524 no 1420 0.397314135389472 1938 2841384
SGTC_837 0091-0265 12.5 µM 0.259048107783326 0.433830123010063 no 1421 0.39779906117451 1829 759367
SGTC_939 1165-0479 45.3 µM 0.257521274802181 0.434388187063886 no 1422 0.398388197027553 1985 1377347
SGTC_1350 1495-0454 146 µM 0.256461050235756 0.434775780725466 no 1423 0.398797426155427 1938 1069057
SGTC_902 1120-0002 2.07 µM 0.25644160947331 0.434782888406514 no 1424 0.398804931008166 1814 3280475
SGTC_1921 5740136 50 µM 0.255459805715402 0.435141870206453 no 1425 0.399183992142388 1988 1774243
SGTC_106 0092-0003 11.579 µM 0.254977400595713 0.435318274000799 no 1426 0.399370277084505 1961 1072148
SGTC_709 3807-1509 243 µM 0.254785489438993 0.435388454814447 no 1427 0.399444391624134 1884 1886677 YPL242C IQG1
SGTC_1386 3228-0095 33.8 µM 0.254218341572836 0.435595869435087 no 1428 0.399663440722549 1936 870181
SGTC_408 cantharidin 100 µM 0.253797096197482 0.435749936760995 no 1429 0.399826158455903 1879 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1553 gossypol 38.6 µM 0.253705442972279 0.435783459530835 no 1430 0.399861564366675 1904 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1315 1237-0019 3.69 µM 0.253448091017516 0.435877590166568 no 1431 0.399960984585098 1955 825140
SGTC_1133 3473-0247 50 µM 0.25243344896343 0.436248747235775 no 1432 0.400353024274558 1751 711311
SGTC_1633 st005664 67.9 µM 0.25227004776366 0.436308524813884 no 1433 0.400416168997929 1818 2063822
SGTC_1072 oxiconazole 14.9 nM 0.251948062819473 0.436426321841549 no 1434 0.400540604404947 1880 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1938 st074717 56.4 µM 0.251792409302343 0.436483269140342 no 1435 0.400600762417975 1839 17250979
SGTC_2104 5389443 200 µM 0.250163483604126 0.43707930564086 no 1436 0.401230461711809 1943 2244536
SGTC_3239 9133757 49.47 µM 0.249897284535433 0.437176723552257 no 1437 0.401333391622203 1932 17036923
SGTC_2193 5925765 200 µM 0.24872798343152 0.437604684704374 no 1438 0.401785600648665 1948 877370
SGTC_1406 3909-7906 11.9 µM 0.248707548510618 0.437612164482595 no 1439 0.401793504707859 1916 X1406
SGTC_983 1491-0821 12.2 µM 0.248656926553366 0.437630693694292 no 1440 0.401813085037234 1962 46495113
SGTC_1280 0880-0253 10.1 µM 0.248455428105042 0.437704449752292 no 1441 0.401891026109648 1867 6836607
SGTC_132 0417-1715 25.805 µM 0.244364209356486 0.439202455276837 no 1442 0.403474379220773 2018 6769098
SGTC_985 1493-0307 8.71 µM 0.2439487637141 0.439354620364953 no 1443 0.403635250903615 1988 3278274
SGTC_2361 9034121 116 µM 0.243000937234251 0.439701813851849 no 1444 0.404002335701232 1855 6496917
SGTC_579 4491-1009 110 µM 0.242680743763696 0.439819112784088 no 1445 0.404126362918356 2060 1271041
SGTC_913 3487-1245 167 µM 0.242185112770472 0.440000691505176 no 1446 0.404318365012578 1811 4016153
SGTC_2070 5230947 200 µM 0.240355501794263 0.440671094377709 no 1447 0.405027335781286 1996 2835538
SGTC_1449 4112-4002 201 µM 0.239440204743104 0.441006539879191 no 1448 0.405382128810288 1816 2059539
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.238877606311338 0.441212746545671 no 1449 0.405600245255361 1862 5355888
SGTC_763 3453-1109 128 µM 0.238443530992895 0.441371857110196 no 1450 0.405768554005257 1997 1560353
SGTC_3138 9097216 49.47 µM 0.237357496847409 0.441769984966371 no 1451 0.406189730104699 2070 25237486
SGTC_2276 7947513 42.08 µM 0.236800985755251 0.441974018473851 no 1452 0.406405593391065 1721 2105100
SGTC_1624 st003710 6.25 µM 0.234894108609568 0.442673252742823 no 1453 0.407145461154127 1995 24207033
SGTC_1993 st073995 70.8 µM 0.234146665949162 0.442947381920906 no 1454 0.407435559251507 1913 3098394
SGTC_135 0933-0004 26.348 µM 0.232882961406793 0.443410915367425 no 1455 0.407926144772748 1829 21230617 YGL099W LSG1
SGTC_870 0573-2213 57.6 µM 0.232341428911425 0.443609576065668 no 1456 0.40813641853534 1965 3916321
SGTC_1165 k072-0275 30.3 µM 0.231580536723631 0.44388873260165 no 1457 0.408431913019713 2011 6153523 YGL055W OLE1
SGTC_2756 carbadox 75.1 µM 0.230460565039731 0.444299679032415 no 1458 0.408866951658348 1876 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2212 7123476 200 µM 0.228935176367725 0.444859479636221 no 1459 0.409459649864675 1976 1085715
SGTC_2656 pseudo-anisatin 100 µM 0.228883192946076 0.444878558915655 no 1460 0.40947985196575 1920 6708809 A neurotoxin.
SGTC_1298 1079-1278 263 µM 0.228080332249397 0.445173246042674 no 1461 0.409791894873661 1894 2840950
SGTC_862 0452-0056 10.2 µM 0.227083437552623 0.445539194801521 no 1462 0.410179431287146 1990 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2250 alverine citrate 130 µM 0.226292598923538 0.445829535735751 no 1463 0.410486927155676 1844 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_395 anisomycin 6.25 µM 0.224928808684311 0.446330292807169 no 1464 0.411017328695194 1883 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1362 1611-0397 101 µM 0.22469936355429 0.446414549000455 no 1465 0.411106579879855 1886 27816
SGTC_286 k060-0067 22.9 µM 0.223304403586254 0.446926854194491 no 1466 0.411649300114199 1924 5985051
SGTC_656 4090-1979 187 µM 0.222034532100944 0.447393297136406 no 1467 0.412143500729523 2036 22330961
SGTC_3101 9120531 49.47 µM 0.222026799458699 0.447396137676038 no 1468 0.412146510498366 2016 24824904
SGTC_698 k064-0052 127 µM 0.220849303200107 0.447828715249062 no 1469 0.412604886428248 1963 5088751
SGTC_1137 ixabepilone 100 µM 0.220307208274814 0.448027885909005 no 1470 0.412815953339199 1834 154225 A novel microtubule stabilizer.
SGTC_261 5-fluorouridine 15.376 µM 0.219015291576787 0.448502600713682 no 1471 0.413319067988579 2003 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_724 3910-0327 137 µM 0.218344519860577 0.448749104915979 no 1472 0.413580344653082 1878 2885483
SGTC_938 3126-1755 342 µM 0.218234236715533 0.448789635144315 no 1473 0.413623305426122 2048 1777771
SGTC_2678 equilin 100 µM 0.218193409266954 0.448804639801317 no 1474 0.413639210011321 2029 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2782 7736369 71.43 µM 0.217582547973491 0.449029148581895 no 1475 0.413877191712321 1887 2950836 YOL077C BRX1
SGTC_1653 st012112 65 µM 0.215250604666501 0.449886353081688 no 1476 0.414785969330566 1999 720429
SGTC_1201 1889-3372 45.9 µM 0.214965737210185 0.449991084287422 no 1477 0.414897015905521 1918 5392199
SGTC_3344 9148862 3.898 µM 0.213957305443267 0.450361861053367 no 1478 0.415290175747363 2006 4905352
SGTC_3189 9110682 49.47 µM 0.213108090985564 0.450674130960321 no 1479 0.415621326953199 1899 17122418
SGTC_2539 epi(13)torulosol 80 µM 0.210670578158471 0.451570612843209 no 1480 0.416572167282298 1880 6708597
SGTC_1898 st060199 18.6 µM 0.20967559013114 0.451936626276833 no 1481 0.416960439144084 1875 688866
SGTC_3183 9108214 49.47 µM 0.207077024984396 0.452892718882245 no 1482 0.417974852307263 2035 4974831
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.206784466294188 0.453000377497041 no 1483 0.418089094031714 1909 6857784
SGTC_2814 7977482 42.97 µM 0.205960398805763 0.453303644475357 no 1484 0.4184109226232 2021 6456762
SGTC_783 0848-0141 92.7 µM 0.20557734375091 0.45344462273323 no 1485 0.418560538288099 1909 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_222 nsc-310342 10.666 µM 0.204924381723009 0.453684950135569 no 1486 0.418815602791787 2050 432556
SGTC_232 clozapine 119 µM 0.203813034149525 0.454094028611231 no 1487 0.41924980342736 1974 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_541 4513-1321 94 µM 0.20318601036538 0.454324852751923 no 1488 0.41949482344123 1884 747515
SGTC_3095 9117207 49.47 µM 0.201578778046329 0.454916588003933 no 1489 0.420123018655582 2066 17015229
SGTC_2894 9048625 32.47 µM 0.201502719191376 0.454944593107319 no 1490 0.420152751716168 2059 4092861
SGTC_1902 st060212 70.5 µM 0.200677583710098 0.455248424882241 no 1491 0.420475344374508 2066 688944
SGTC_2171 5739187 198.077 µM 0.200425772111133 0.455341152289372 no 1492 0.420573802581265 1918 2262761
SGTC_795 0685-0265 78 µM 0.198947418348576 0.45588559197211 no 1493 0.421151938177243 2046 302754
SGTC_3250 9135583 49.47 µM 0.198260300954248 0.456138667906248 no 1494 0.421420705184068 2068 7699353
SGTC_2778 tioconazole 65.09 nM 0.197560064751339 0.456396594007516 no 1495 0.421694641303318 1975 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2739 tacrine 100.86 µM 0.195979457660363 0.456978864681504 no 1496 0.42231312231099 1981 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2888 9058547 12.99 µM 0.195603669548333 0.457117312721728 no 1497 0.422460193940792 1934 16476514
SGTC_2647 atorvastatin 60.16 µM 0.194264004128311 0.457610915147163 no 1498 0.422984584615896 2032 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2154 5570129 200 µM 0.193806299707299 0.457779572289459 no 1499 0.423163777043882 2045 673366
SGTC_2464 5717415 7.67 µM 0.193755352954386 0.457798345866567 no 1500 0.423183723809169 1873 5285744
SGTC_1934 st074720 32.6 µM 0.192988824018137 0.458080818587939 no 1501 0.423483860350734 1918 17250992
SGTC_3325 9138760 55.175 µM 0.192864736634577 0.458126547885866 no 1502 0.423532451291933 1915 43844959
SGTC_1748 st037455 53.6035 µM 0.191523437285309 0.458620885423858 no 1503 0.424057760048688 1974 580690
SGTC_3186 9110464 49.47 µM 0.190244421215109 0.459092328005697 no 1504 0.424558801798241 2060 17018021
SGTC_907 3448-6986 75.5 µM 0.19012717001664 0.459135549435173 no 1505 0.424604739895414 2054 590582
SGTC_859 0439-0102 54.6 µM 0.189413992483695 0.459398453103457 no 1506 0.424884179278648 2097 610143
SGTC_1707 st032323 6.317 µM 0.189368518720492 0.459415217021181 no 1507 0.424901998228146 2007 3132057 YMR211W DML1
SGTC_139 0099-0334 718.624 µM 0.186920105427785 0.460317931154769 no 1508 0.425861637583983 2126 97690
SGTC_418 lividomycin a 100 µM 0.186392132299502 0.460512618401479 no 1509 0.426068630918271 2070 72394 An antibiotic.
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.185647388761982 0.460787254652022 no 1510 0.426360644315753 2050 88881 An O-methylated flavonoid and antioxidant.
SGTC_613 3914-0030 117 µM 0.184706236647192 0.461134346487549 no 1511 0.426729727106473 2018 1145395
SGTC_1667 st014849 34.6 µM 0.18448242524065 0.461216891297617 no 1512 0.426817506580598 2062 5348460
SGTC_1636 st007707 68.9 µM 0.184293062759742 0.461286732162086 no 1513 0.426891777918232 2065 403051
SGTC_1233 0325-0408 14.2 µM 0.183952180039821 0.461412459884403 no 1514 0.427025484723258 2045 12874
SGTC_2283 7944793 200 µM 0.182526900113891 0.461938187296056 no 1515 0.427584622846847 1937 2970533
SGTC_2812 7970281 58.44 µM 0.18241084231458 0.461980999207358 no 1516 0.42763015880754 2055 2233435
SGTC_956 1185-0240 191 µM 0.180647583194337 0.462631491883747 no 1517 0.428322102139793 1993 1416193
SGTC_2676 harmalol 100 µM 0.179950866223825 0.462888548845819 no 1518 0.428595570738411 2066 5459187 A monoamine oxidase inhibitor
SGTC_1868 st057644 42.7 µM 0.179772169022465 0.462954482509774 no 1519 0.428665716763624 2043 688665
SGTC_2867 9039098 71.43 µM 0.178822492737688 0.463304900313384 no 1520 0.429038541650659 1953 6463460
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.178659762225273 0.463364948553589 no 1521 0.429102432925298 2135 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3247 9135149 49.47 µM 0.177871527151108 0.46365582238416 no 1522 0.429411936141764 2076 8934436 YOR116C RPO31
SGTC_632 0781-2353 4.65 µM 0.176848908432267 0.464033217197912 no 1523 0.429813535547562 2023 6811515 YHR007C ERG11
SGTC_204 PMA1.184 62.41 µM 0.176687944906937 0.464092623330556 no 1524 0.429876755232044 2084 2252213 YGL008C PMA1
SGTC_1684 st024538 14.6195 µM 0.175717504487401 0.464450796618264 no 1525 0.430257941343698 1947 6732859
SGTC_1691 st019933 84.6 µM 0.17513123884496 0.464667191415053 no 1526 0.430488256265919 2130 6176082
SGTC_1199 1638-0010 4.46 µM 0.173825164176527 0.46514931029759 no 1527 0.431001433647292 1935 3111136
SGTC_2374 9071832 200 µM 0.172924471784324 0.465481817930248 no 1528 0.431355397859467 2095 17381698
SGTC_1701 st028638 40.4 µM 0.172170764475745 0.465760081771128 no 1529 0.431651640607016 2076 3490878
SGTC_2305 7443522 69.23 µM 0.171003794644751 0.466190952428119 no 1530 0.432110390925981 2027 5415886
SGTC_3221 9128209 49.47 µM 0.170985744168988 0.466197617369118 no 1531 0.432117487512552 2000 16460723
SGTC_1370 2001-0092 44.6 µM 0.170740300545839 0.466288245685903 no 1532 0.432213986417257 2092 790957
SGTC_2470 5664817 21.68 µM 0.170550161344813 0.466358454439016 no 1533 0.43228874455024 2140 2859561
SGTC_1297 1068-0111 14.1 µM 0.170374160008966 0.466423443729417 no 1534 0.432357946177418 1974 767057
SGTC_3326 9140064 16.379 µM 0.170190071773853 0.466491420101905 no 1535 0.432430329697279 2009 1868434
SGTC_2622 2-methoxyxanthone 59.94 µM 0.169622978334232 0.466700831008821 no 1536 0.432653325160469 2088 71034 A hepatoprotective.
SGTC_1025 k007-0731 70 µM 0.169602663268663 0.466708332935651 no 1537 0.432661313955745 1905 6256118
SGTC_746 1095-0025 46.6 µM 0.166699762742598 0.467780433403695 no 1538 0.433803146114293 2078 6749286
SGTC_1608 st001473 40.5 µM 0.16627491720804 0.46793735733223 no 1539 0.433970302212737 1939 7292267
SGTC_711 k292-0785 179 µM 0.166153536089731 0.467982192430214 no 1540 0.434018061961816 2068 4146315
SGTC_2491 paeonol 100 µM 0.166057204688862 0.468017775088767 no 1541 0.434055966100584 1987 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1042 0350-0096 82 µM 0.165500204730671 0.468223523379938 no 1542 0.434275144351444 1919 3122515
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.16296300617741 0.46916083696535 no 1543 0.435273781017886 2122 688662
SGTC_725 1497-0963 19 µM 0.162131316435345 0.469468124356787 no 1544 0.435601222747373 2132 3549977
SGTC_2642 cholecalciferol 100 µM 0.162086653623732 0.469484626602122 no 1545 0.435618808041743 2100 9821465 A vitamin D precursor, similar to steriods.
SGTC_2773 thioridazine 9.09 µM 0.161414297170785 0.46973305864049 no 1546 0.435883553406448 2151 5452 An antipsychotic.
SGTC_3017 9080681 49.47 µM 0.161160129554641 0.469826975261162 no 1547 0.435983641290147 1991 16451914
SGTC_825 1988-2224 89.6 µM 0.159790305307995 0.470333163180579 no 1548 0.436523130598277 2020 1180859
SGTC_2447 5741742 33.78 µM 0.158549156276175 0.470791843472402 no 1549 0.437012044679362 2070 1776504
SGTC_689 0833-0039 98 µM 0.15722084548428 0.471282778266561 no 1550 0.43753540014042 2109 5374726
SGTC_661 1304-0007 33.6 µM 0.156078983094941 0.471704837888358 no 1551 0.437985382193188 2000 3117130
SGTC_3004 9076122 71.4286 µM 0.155978552350448 0.471741961018425 no 1552 0.438024963515912 2101 44782551
SGTC_1783 st039459 87.517 µM 0.155135053885926 0.472053760691039 no 1553 0.438357423850993 2140 729761
SGTC_1116 jasmonic acid 1.58368 µM 0.154254385593046 0.472379318484779 no 1554 0.438704580893654 2105 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1879 gemcitabine 100 µM 0.154004571544961 0.472471670938195 no 1555 0.438803065509297 2084 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2914 7968218 45.32 µM 0.153410444954072 0.472691316437151 no 1556 0.439037304252661 2097 2977111
SGTC_2531 methyl deoxycholate 70.07 µM 0.153295384564038 0.472733854624572 no 1557 0.439082670121258 2015 16667744 Haematoxylin.
SGTC_821 1114-0266 29.2 µM 0.152515414178432 0.473022220299098 no 1558 0.439390216949695 2031 3123235
SGTC_2796 7949634 45.45 µM 0.152226469995631 0.473129050495988 no 1559 0.439504158607273 2053 2971588
SGTC_1056 3448-1962 115 µM 0.152202449397276 0.473137931624515 no 1560 0.439513631066627 2045 715507
SGTC_753 1322-0200 289 µM 0.151738046530785 0.473309637774482 no 1561 0.439696773907969 2066 5403907
SGTC_3121 9125696 49.47 µM 0.151547338295246 0.473380150786291 no 1562 0.439771985728743 2179 1235365
SGTC_2534 helenine 20.12 µM 0.150005635789304 0.473950214743244 no 1563 0.440380084428304 2042 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_973 1325-0077 65.9 µM 0.149863538178294 0.474002759830896 no 1564 0.44043613954866 2099 2835149
SGTC_3143 9086658 49.47 µM 0.149553789978145 0.474117300594599 no 1565 0.440558334145576 1978 25236626
SGTC_2636 apigenin dimethyl ether 100 µM 0.149286874261974 0.474216004192171 no 1566 0.440663636016323 2059 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1749 st037932 54.2 µM 0.148921301728026 0.474351192970166 no 1567 0.440807866147576 2036 594497
SGTC_2106 5357045 167.29 µM 0.148274158476804 0.47459051387376 no 1568 0.44106320423126 2105 668842
SGTC_2999 9069765 71.4286 µM 0.147800643692367 0.474765630817824 no 1569 0.441250050662747 2085 2097066
SGTC_2842 9000675 19.48 µM 0.147452451749112 0.474894403529579 no 1570 0.441387453709223 1930 2989072
SGTC_3305 9127027 53.8275 µM 0.146569069552044 0.475221118750775 no 1571 0.441736084445329 2051 41905295
SGTC_2956 9076196 2.52 µM 0.146506934988339 0.475244099589783 no 1572 0.441760607831236 2170 16423868
SGTC_2288 7946289 167.31 µM 0.146393474650294 0.475286063785029 no 1573 0.44180538914578 2143 1246052
SGTC_3230 9131665 49.47 µM 0.146309500858019 0.475317122326793 no 1574 0.441838532984574 2086 15943720
SGTC_604 1000-0114 314 µM 0.145498334133557 0.475617148096843 no 1575 0.442158715462007 2141 1572745
SGTC_3012 9080433 71.4286 µM 0.145417711399654 0.475646968739226 no 1576 0.442190540811193 2151 17688859
SGTC_1302 1159-0335 255 µM 0.144948106156785 0.4758206684824 no 1577 0.442375922123659 2026 649284
SGTC_1123 mangostin 811.285 nM 0.143984743733489 0.476177015744491 no 1578 0.442756258417118 1999 5281650 An antioxidant.
SGTC_1418 3966-3099 2.4 µM 0.142739944691594 0.476637494441549 no 1579 0.443247784205246 2123 740335
SGTC_2056 5235370 200 µM 0.14231080138078 0.476796251306691 no 1580 0.443417257547105 2026 5511916
SGTC_664 1222-0054 14.9 µM 0.1411051561131 0.477242286188355 no 1581 0.443893435210146 2110 6813991
SGTC_365 0121-0052 13.6 µM 0.140792013127987 0.477358139788665 no 1582 0.444017126407883 2093 3101739
SGTC_3202 9113761 49.47 µM 0.14054286661541 0.477450317963037 no 1583 0.444115542952599 2140 4798415
SGTC_351 caspofungin 25 nM 0.138864438004266 0.478071327085955 no 1584 0.444778636502174 2080 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1141 3253-0389 52.6 µM 0.138700596740047 0.478131950306816 no 1585 0.444843373264066 2151 5402031
SGTC_572 0960-0087 17.7 µM 0.137992869188269 0.478393823733216 no 1586 0.445123026597949 2086 6796365
SGTC_2334 9017922 200 µM 0.137990346286174 0.478394757274479 no 1587 0.445124023553083 2129 3163164
SGTC_153 4077-0274 519.67 µM 0.137549333398042 0.478557945657127 no 1588 0.445298300432282 2175 3121976
SGTC_2691 st077356 60.2 µM 0.13674967656222 0.478853852521365 no 1589 0.44561433105863 2118 2839272
SGTC_2403 6032726 181.2 µM 0.135953528744064 0.479148472480299 no 1590 0.445929009227653 2066 2881040
SGTC_2492 derrusnin 100 µM 0.134533797327583 0.479673881995185 no 1591 0.44649024379937 2065 1715307 Part of coumarin class of compounds.
SGTC_3032 9089427 49.47 µM 0.134364453911734 0.479736554422902 no 1592 0.446557194188307 2065 17173707
SGTC_1565 sinapyl alcohol 95.1 µM 0.134297119149083 0.479761474533381 no 1593 0.446583815596796 2036 5280507 A phenol propionate derived from cinnamic acid.
SGTC_721 1187-1332 279 µM 0.133976812874087 0.479880018659291 no 1594 0.446710454878954 2115 25730
SGTC_1820 st053765 18.6 µM 0.133834821349584 0.47993256974873 no 1595 0.446766595714342 2031 3690829
SGTC_1159 4092-0538 61.2 µM 0.133701751818278 0.479981819123467 no 1596 0.446819209926282 2159 717301
SGTC_2263 7948595 193.29 µM 0.133392419916265 0.480096304833115 no 1597 0.446941519933902 2031 2971371
SGTC_1803 st050068 52.4 µM 0.133379059052245 0.480101249811154 no 1598 0.446946802940818 2171 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2344 7990960 76.95 µM 0.132756110684836 0.480331812089663 no 1599 0.447193132817025 2066 140813
SGTC_2630 antimycin a 100 µM 0.132719959132341 0.480345192509386 no 1600 0.447207428701078 2128 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1385 3091-4834 14.1 µM 0.131675656893247 0.480731719358827 no 1601 0.447620420410831 2110 4072814
SGTC_1720 st037298 9.481 µM 0.131394180026077 0.480835905307417 no 1602 0.447731746208159 2062 597396
SGTC_2774 tamoxifen 10.92 µM 0.131393084450952 0.480836310826549 no 1603 0.447732179522773 2149 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_2477 5967686 25.23 µM 0.131180976017302 0.480914821587388 no 1604 0.447816072419489 2075 776118
SGTC_2248 tofa 1.1 µM 0.130396790815903 0.481205089796411 no 1605 0.448126252735933 2052 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_433 pimozide 108 µM 0.129759413357383 0.481441024082724 no 1606 0.448378387401125 2020 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2059 5238311 157 µM 0.128718553796219 0.481826326917703 no 1607 0.448790176868349 2085 703021
SGTC_1129 3453-1384 223 µM 0.128576204830683 0.481879022635676 no 1608 0.448846497894885 2106 1084452
SGTC_2765 myclobutanil 7.74 µM 0.128065825964222 0.482067960786702 no 1609 0.449048440119545 2077 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2661 dactinomycin 12.96 µM 0.127998176987455 0.482093004196972 no 1610 0.44907520786404 2173 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_345 1362-0200 395 µM 0.127993034890113 0.482094907785986 no 1611 0.449077242528801 2027 1419823
SGTC_2792 7535235 81.82 µM 0.126950006108466 0.482481042291609 no 1612 0.449489983817726 2038 1281891
SGTC_3342 9147791 14.508 µM 0.125190144359895 0.483132589038991 no 1613 0.450186509761194 2171 1838168
SGTC_2790 5423970 71.43 µM 0.122997788979933 0.483944319029841 no 1614 0.451054424405829 2170 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2592 piperlongumine 83.33 µM 0.122961507481118 0.483957752996114 no 1615 0.45106878958847 2060 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_401 neomycin 50 µM 0.122755509975559 0.48403402812645 no 1616 0.451150352807914 2092 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1733 st037357 54.9 µM 0.122376136963191 0.484174500897682 no 1617 0.451300568197232 2156 1272339 YGL099W LSG1
SGTC_1759 st043059 70 µM 0.121574373314432 0.48447138128027 no 1618 0.451618055022138 2073 669426
SGTC_2619 obliquin 87.91 µM 0.120641641622075 0.484816767876798 no 1619 0.451987442231103 2153 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2349 9023730 187.07 µM 0.120321733204178 0.484935231246122 no 1620 0.45211414428588 2157 4126287
SGTC_2696 st077691 74.316 µM 0.119505650647672 0.485237435885367 no 1621 0.452437381775401 2119 757133
SGTC_2035 5154463 94.595 µM 0.11936189889791 0.485290669674225 no 1622 0.452494322858563 2173 2769623
SGTC_473 2-arachidonoylglycerol 10 µM 0.11804132057467 0.485779715084495 no 1623 0.453017458823971 2025 5282280 An endocannabinoid.
SGTC_2505 galangin 7.89 µM 0.117157131453995 0.486107165921736 no 1624 0.453367768524844 2036 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3002 9075603 71.4286 µM 0.117125715160584 0.486118800813943 no 1625 0.453380216115306 2216 20105405
SGTC_2033 5192550 145 µM 0.11565315043574 0.486664172057539 no 1626 0.45396371876803 2100 182073
SGTC_10 0279-0212 42.575 µM 0.11403615897601 0.487263061111678 no 1627 0.454604564839482 2194 39851 YBR002C RER2
SGTC_2259 7964009 200 µM 0.111505795198154 0.488200295224681 no 1628 0.455607635178234 2163 313134
SGTC_750 4073-0104 132 µM 0.111480125139845 0.488209803628802 no 1629 0.455617812596729 2210 22330957
SGTC_2281 7943571 200 µM 0.110957445156278 0.488403410112545 no 1630 0.455825046067778 2243 1244024
SGTC_429 1112-0049 25.5 µM 0.110665072285603 0.488511709472949 no 1631 0.45594097204242 2013 2836170
SGTC_668 1682-0499 62.6 µM 0.11040862101526 0.488606703623605 no 1632 0.456042658174658 2086 682214
SGTC_214 4373-3496 70 µM 0.110191732420513 0.488687043554242 no 1633 0.456128659459298 2154 3779166
SGTC_1376 2910-0861 41.3 µM 0.108989223383246 0.489132485508421 no 1634 0.456605518954511 2199 1112859
SGTC_655 k060-0012 42 µM 0.108889651225199 0.489169370351035 no 1635 0.456645007480709 2122 5994525
SGTC_962 1254-0300 21.5 µM 0.108697135721282 0.48924068476592 no 1636 0.456721356879279 2140 7340576
SGTC_84 0443-0269 128.823 µM 0.108362394561018 0.489364685310894 no 1637 0.456854115113266 2207 6150058
SGTC_1722 st034304 3.6505 µM 0.107295008443694 0.489760091536523 no 1638 0.457277472184583 2131 4036148 YLR033W RSC58
SGTC_3282 9108498 15.4605 µM 0.107203723525804 0.489793907911631 no 1639 0.457313680754696 2113 16459645
SGTC_3022 9087993 49.47 µM 0.106835723476342 0.489930233776748 no 1640 0.457459653207311 2224 17173644
SGTC_1775 st081588 35.1725 µM 0.106732125602761 0.489968611891378 no 1641 0.457500747813122 2216 1426443 YGL099W LSG1
SGTC_752 1896-0090 130 µM 0.10631858285088 0.490121810852732 no 1642 0.457664794084996 2205 772567
SGTC_2255 7941087 197.44 µM 0.105200448220238 0.490536036599212 no 1643 0.458108377534447 2231 935561
SGTC_1810 st050138 53 µM 0.105012786882918 0.490605558897741 no 1644 0.458182831178626 2233 3444541
SGTC_338 4055-0136 114 µM 0.10491756498624 0.490640835560107 no 1645 0.458220610524386 2204 2900563
SGTC_162 k030-0015 37.8 µM 0.104908638903697 0.490644142391506 no 1646 0.458224151972449 2193 1809920 YMR134W ERG29
SGTC_1220 1838-0075 193 µM 0.104815984793174 0.490678467848296 no 1647 0.458260912944199 2148 5529645
SGTC_1718 roemerine 11.9335 µM 0.0999207791185844 0.492492080728939 no 1648 0.460203609778192 2227 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1096 rimcazole 32.2 µM 0.0995650486995297 0.492623880930389 no 1649 0.460344821499158 2104 18528119 A dopamine reuptake inhibitor.
SGTC_399 oxolinic acid 75 µM 0.0995402220793675 0.492633079368634 no 1650 0.460354676929177 2099 4628 A DNA gyrase inhibitor.
SGTC_2292 7671323 168.05 µM 0.0987560081051667 0.492923638179452 no 1651 0.460665999063083 2126 937504
SGTC_3262 9137218 49.47 µM 0.0987112102294315 0.492940236337579 no 1652 0.460683783931834 2244 17650664
SGTC_765 1319-0117 244 µM 0.0981339685377509 0.49315411249238 no 1653 0.460912957350841 2247 3487746 YGL099W LSG1
SGTC_3067 9117431 49.47 µM 0.0967825585997246 0.493654836446026 no 1654 0.461449537562378 2133 17150885
SGTC_3253 9135987 49.47 µM 0.0966790825670821 0.493693176772753 no 1655 0.461490625847927 2199 4182430
SGTC_839 0122-0028 230 µM 0.0966292971213426 0.493711623483141 no 1656 0.461510394810038 2159 759448
SGTC_1417 3966-0327 90.4 µM 0.0958908620180564 0.493985233085925 no 1657 0.461803626094544 2158 651118
SGTC_1115 galangin 695.678 nM 0.0946404670105335 0.494448543665843 no 1658 0.462300203024109 2221 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3114 9122766 49.47 µM 0.0938935481628319 0.494725304145248 no 1659 0.462596859508447 2100 17176985
SGTC_2974 9094440 9.66 µM 0.0912807166066191 0.49569347195096 no 1660 0.463634769966335 2172 25236134
SGTC_1216 1165-0504 9.65 µM 0.0903518587677651 0.496037660612309 no 1661 0.46400380564636 2240 6304004
SGTC_3051 9093778 49.47 µM 0.0895026335229436 0.496352343970075 no 1662 0.464341230368305 2259 17217378
SGTC_2810 7959871 45.46 µM 0.0881590758275575 0.4968502084891 no 1663 0.464875121691178 2198 2974535
SGTC_3291 9121177 71.43 µM 0.0876107753261675 0.49705338645397 no 1664 0.465093018821279 2170 17015612
SGTC_869 0564-0080 44.1 µM 0.0871530723313341 0.497222993238783 no 1665 0.465274920106073 2085 6843321
SGTC_533 1222-0222 6.71 µM 0.0868452670972679 0.497337054074635 no 1666 0.465397252791255 2230 3982874
SGTC_820 1582-0060 59.9 µM 0.0865827225856317 0.497434343191884 no 1667 0.465501599849437 2159 3848840
SGTC_2469 5655019 90.81 µM 0.0860087884238436 0.497647022120227 no 1668 0.465729715482623 2228 2788239
SGTC_1769 st044406 64.4 µM 0.085237366299017 0.49793288387947 no 1669 0.46603634232565 2104 670903
SGTC_2041 5107442 45.335 µM 0.0847541408089584 0.498111950707491 no 1670 0.46622842631404 2249 793005
SGTC_638 3970-0837 4.09 µM 0.082246350400003 0.499041257303225 no 1671 0.467225407989721 2176 4118451 YLR208W SEC13
SGTC_3172 9105863 49.47 µM 0.0819875582733207 0.499137157737015 no 1672 0.467328303602555 2254 2348785
SGTC_116 0155-0182 31.788 µM 0.0810203362686816 0.499495580976755 no 1673 0.467712889833398 2104 771486
SGTC_809 3998-0021 90 µM 0.0807665534107322 0.499589625312302 no 1674 0.467813803826523 2266 715485
SGTC_3171 9103192 49.47 µM 0.0796776704666547 0.499993132952524 no 1675 0.4682468096824 2268 13018434
SGTC_1238 0333-0287 48.8 µM 0.079659139443232 0.5 no 1676 0.468254179067049 2220 7226
SGTC_2363 9053361 176 µM 0.0793494552957572 0.499885240244665 no 1677 0.468377335319603 2271 6469797 YMR079W SEC14
SGTC_1907 st060210 83.7 µM 0.0793361586658217 0.499880312908327 no 1678 0.468382623236786 2232 688793
SGTC_3254 9136651 49.47 µM 0.0785661079666022 0.499594955033916 no 1679 0.468688873051652 2279 16454030
SGTC_1860 st056228 74.6 µM 0.0781605232111366 0.499444657466754 no 1680 0.468850181913179 2148 688679
SGTC_2244 6635614 200 µM 0.0780146162587891 0.499390588736835 no 1681 0.46890821316776 2113 836499
SGTC_2434 5670830 169.91 µM 0.0780116193683695 0.499389478179459 no 1682 0.468909405121391 2195 1549830
SGTC_2272 7805186 180 µM 0.0764914950873221 0.498826166677493 no 1683 0.469514040045026 2286 2956062 YPR165W RHO1
SGTC_2558 carylophyllene oxide 100 µM 0.0752820324065933 0.498377978467176 no 1684 0.469995158486658 2289 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3159 9100096 49.47 µM 0.0744150393441066 0.498056699777604 no 1685 0.470340071158189 2259 25236875
SGTC_784 4579-0127 173 µM 0.0735684850637905 0.497742996233023 no 1686 0.470676874218719 2278 1948547
SGTC_2479 5617353 43.85 µM 0.0734827808391522 0.497711237305612 no 1687 0.47071097296362 2244 2731746
SGTC_2260 7964312 200 µM 0.0717862475432457 0.497082565849671 no 1688 0.471386008726452 2275 231951
SGTC_922 1866-0035 480 µM 0.0716439965702385 0.497029853294742 no 1689 0.471442612907336 2129 3156169
SGTC_1277 0873-0036 22 µM 0.0700818647705843 0.49645099297055 no 1690 0.472064250511993 2251 5965735
SGTC_29 0299-0004 12.984 µM 0.0699962894509633 0.496419282562143 no 1691 0.472098306492282 2264 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2149 5554786 194.827 µM 0.0687856398992627 0.495970672187093 no 1692 0.472580124356307 2216 745063 YPR165W RHO1
SGTC_2618 avocadyne 43.43 µM 0.06836851124305 0.495816104873596 no 1693 0.472746143773779 2220 3015189
SGTC_1772 st048439 82.2 µM 0.068081849766637 0.495709882626996 no 1694 0.472860239308422 2160 2927068 YDL195W SEC31
SGTC_404 fumagillin 50 µM 0.0680107048807087 0.49568351997691 no 1695 0.472888556377297 2172 12015870 A methionine aminopeptidase binder.
SGTC_2121 5257820 149.641 µM 0.0678468499700893 0.495622803812952 no 1696 0.472953774386867 2291 791256
SGTC_2237 6667747 47.222 µM 0.0678131219360751 0.495610305958716 no 1697 0.472967199007405 2127 729940 YDL015C TSC13
SGTC_310 1273-0058 1.06 µM 0.067809384282534 0.495608920979081 no 1698 0.47296868669104 2261 2734232
SGTC_2567 aureobasidin a 60 nM 0.0675342583552229 0.495506973793613 no 1699 0.473078195022888 2179 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_64 000l-0018 272.079 µM 0.0673636033261748 0.495443738170507 no 1700 0.473146121841674 2225 6811119
SGTC_514 4466-0038 2.65 nM 0.0658092796683915 0.494867794452455 no 1701 0.473764834073604 2171 5722064
SGTC_1354 1498-1681 81 µM 0.0652235928161344 0.494650775011874 no 1702 0.473997988385178 2203 5754243
SGTC_1343 1487-0095 224 µM 0.0646638867975732 0.494443383945035 no 1703 0.474220808389083 2288 4560101 YGL055W OLE1
SGTC_1041 0206-0046 107 µM 0.0645041456060505 0.494384194402289 no 1704 0.474284403135966 2179 50494
SGTC_1614 st002383 48.6 µM 0.0642869736641954 0.494303725012417 no 1705 0.474370862754689 2306 1947235
SGTC_2450 5739737 12.93 µM 0.0637037555994465 0.494087624579063 no 1706 0.474603057143761 2214 2262825
SGTC_1324 1418-0026 34.4 µM 0.0636587002116296 0.494070930227863 no 1707 0.474620995233862 2204 1372513
SGTC_2301 7769476 200 µM 0.0629947159071104 0.493824905662189 no 1708 0.474885356030471 2230 977820
SGTC_2971 9092186 9.93 µM 0.0625642416266012 0.493665404273736 no 1709 0.475056752328313 2105 25236400
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.0620746969436356 0.493484017069505 no 1710 0.475251673521505 2222 676296 Flavone; oxidizing agent.
SGTC_1170 0310-0127 64.8 µM 0.0598726019436848 0.49266810904581 no 1711 0.476128550608999 2262 774975
SGTC_3195 9113082 49.47 µM 0.0584050041308336 0.492124359667848 no 1712 0.476713014429353 2312 17018038
SGTC_1817 st052116 64.4 µM 0.058396488358307 0.492121204590391 no 1713 0.476716405942503 2280 4361398
SGTC_2519 cryptotanshinone 88.04 µM 0.0582174962502531 0.492054888470567 no 1714 0.476787692183013 2302 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_681 1642-0006 26.6 µM 0.0573629840257409 0.49173829692778 no 1715 0.477128024447545 2310 4446530
SGTC_555 4296-0685 37 µM 0.055858959276215 0.491181077738774 no 1716 0.477727082753358 2313 2908540 YHR072W ERG7
SGTC_3242 9133940 49.47 µM 0.0554939432539783 0.491045847190886 no 1717 0.477872477549834 2287 17248444
SGTC_1479 0549-0158 134 µM 0.0524570459689087 0.489920783749014 no 1718 0.479082260267049 2308 5440202
SGTC_757 1066-0008 322 µM 0.0521303520153751 0.489799759768587 no 1719 0.47921241421406 2287 6842497
SGTC_2034 5197015 53.07 µM 0.0507119055979375 0.489274306436125 no 1720 0.479777544780998 2289 780676
SGTC_2357 9067248 200 µM 0.0497419811591176 0.488915015524551 no 1721 0.480164000860508 2251 9150235
SGTC_2113 5491891 107.031 µM 0.0490645828111964 0.488664090913876 no 1722 0.480433914109439 2286 789979
SGTC_2822 7994718 71.43 µM 0.0487665574602661 0.488553696584465 no 1723 0.48055266686528 2322 1018011
SGTC_2024 5144227 134 µM 0.0482051340076276 0.48834573691441 no 1724 0.48077637929997 2305 3475211
SGTC_2186 6124449 200 µM 0.0482028504984677 0.488344891074789 no 1725 0.480777289230538 2294 3834182 YLR033W RSC58
SGTC_3175 9106517 49.47 µM 0.0479133702729514 0.488237664497302 no 1726 0.48089264184633 2270 41468073
SGTC_2968 9090663 33.37 µM 0.0473524259192499 0.488029887124719 no 1727 0.481116172535548 2201 25236811
SGTC_1752 st044819 83.042 µM 0.0473224430243851 0.488018781359862 no 1728 0.481128120585705 2276 441209 YML126C ERG13
SGTC_3213 9129884 49.47 µM 0.0469401877584125 0.487877193544011 no 1729 0.481280449089998 2281 17190742
SGTC_2555 cholic acid 100 µM 0.0442544013964037 0.486882419097795 no 1730 0.482350809226016 2254 6708657 Influences liver metabolism.
SGTC_2411 st077133 39.94 µM 0.0442079204032479 0.486865203945012 no 1731 0.482369334329338 2310 1403142 YNL221C POP1
SGTC_1303 1160-0052 261 µM 0.0441960787304014 0.486860818151774 no 1732 0.482374053860504 2326 3562476
SGTC_1000 4048-0884 8.67 µM 0.0435514491600988 0.486622069498316 no 1733 0.482630976451749 2279 13040088
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0431139810846339 0.486460049073555 no 1734 0.482805337184435 2323 1273210
SGTC_375 3970-0961 9.27 µM 0.0429036678640413 0.486382158384013 no 1735 0.482889162455964 2287 2898222
SGTC_1935 st074532 41.6 µM 0.0403143069409802 0.485423217426002 no 1736 0.483921273881187 2307 2829742
SGTC_1284 0929-0043 16 µM 0.0400713106094927 0.48533323068328 no 1737 0.48401813712052 2285 1239883
SGTC_160 3453-0671 289.699 µM 0.0382800394375479 0.484669907973574 no 1738 0.484732202670821 2328 5322268
SGTC_2520 obtusaquinone 4.71 µM 0.0375485938166012 0.484399059630765 no 1739 0.485023797589821 2321 5967872
SGTC_673 1082-0474 110 µM 0.0364432421851318 0.483989770642573 no 1740 0.485464467392765 2317 3098046
SGTC_1889 st059080 5.18 µM 0.0359661450176968 0.483813116555027 no 1741 0.485654676920645 2338 176925 Isolated from Daphnopsis sellowiana.
SGTC_1130 3454-2858 15.9 µM 0.0350033355074821 0.483456628162928 no 1742 0.486038540577147 2219 715628 YIL048W NEO1
SGTC_2686 alizarin 95.37 µM 0.0333861101814922 0.482857866668426 no 1743 0.486683342979198 2303 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1022 4477-0945 21.3 µM 0.0323406721631164 0.482470824191759 no 1744 0.487100187230095 2346 4648966
SGTC_1325 1431-0015 227 µM 0.0301016498535608 0.481641948510104 no 1745 0.487992992467865 2344 1103340
SGTC_1179 1021-1431 9.29 µM 0.0298204032970008 0.481537837874426 no 1746 0.488105143262011 2312 2840958
SGTC_659 k018-0002 107 µM 0.0292909536428787 0.4813418519099 no 1747 0.488316270877767 2352 6797879 YHR007C ERG11
SGTC_1112 tnp00069 1.16933 µM 0.0289230244050228 0.481205658484472 no 1748 0.488462991240972 2343 145826
SGTC_3086 9117350 49.47 µM 0.0283554602833658 0.480995572117073 no 1749 0.488689323724214 2362 2679265
SGTC_2298 7976326 193.81 µM 0.0282857719913508 0.480969777050515 no 1750 0.488717114183337 2326 2235818
SGTC_3116 9124943 49.47 µM 0.0272480423239684 0.480585671715818 no 1751 0.489130948840472 2344 41905195 YPL160W CDC60
SGTC_2482 5981709 142.65 µM 0.0258276392606571 0.480059952913885 no 1752 0.489697408128456 2351 877755
SGTC_1989 st071868 50.2 µM 0.0254912884314209 0.479935467974403 no 1753 0.489831548527823 2358 16414057
SGTC_2426 5582046 32.21 µM 0.0249930795184227 0.479751082237054 no 1754 0.490030241815065 2355 2251934
SGTC_1409 3909-8004 61.9 µM 0.0235225471012763 0.47920686768484 no 1755 0.490616726736714 2325 2119279
SGTC_1462 k081-0014 26.5 µM 0.0229968232396783 0.479012317181507 no 1756 0.490826403483917 2348 3270634
SGTC_391 gliotoxin 8.33 µM 0.0222879672789369 0.47875000434453 no 1757 0.491109123609961 2341 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2364 9055074 200 µM 0.0207595780692069 0.478184453898664 no 1758 0.491718721405921 2359 6470630
SGTC_38 0929-0051 58.268 µM 0.0207509971823904 0.478181278832758 no 1759 0.491722143947211 2367 1379719
SGTC_1850 st056238 17 µM 0.020482049214931 0.47808176446921 no 1760 0.49182941586243 2366 5393177
SGTC_1805 st050013 60.3 µM 0.0181074374898674 0.47720318620723 no 1761 0.492776572333115 2352 4037144
SGTC_254 nsc-64875 3.808 µM 0.0180614038474527 0.477186155384765 no 1762 0.492794934096575 2372 56993
SGTC_2996 9066192 71.4286 µM 0.0165017922105054 0.476609178962148 no 1763 0.493417036153064 2366 6472854
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.0153824095726053 0.476195094877279 no 1764 0.493863548447675 2371 94937 An inhibitor of serotonin biosynthesis.
SGTC_2525 harmine 47.85 µM 0.0143775697733522 0.47582340457172 no 1765 0.49426437713475 2373 5280953 A monoamine oxidase inhibitor
SGTC_1206 3978-0017 132 µM 0.0131325405141991 0.475362897385705 no 1766 0.494761024929002 2336 3873677
SGTC_3218 9131285 49.47 µM 0.0126559370249008 0.475186621585523 no 1767 0.494951146404483 2383 17156417
SGTC_1164 k060-0068 93.7 µM 0.012627197907773 0.475175992336796 no 1768 0.494962610737317 2383 5963676
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0117751142569926 0.47486085470119 no 1769 0.495302517620163 2389 5024745
SGTC_2438 5259590 200 µM 0.0116086071835773 0.474799274966162 no 1770 0.49536893979156 2377 1201127
SGTC_1508 1080-0625 72.9 µM 0.0106943689020331 0.474461170660956 no 1771 0.495733645406416 2371 767111
SGTC_700 3453-2283 142 µM 0.00946479224673539 0.474006476722451 no 1772 0.49622415057252 2375 565664
SGTC_2014 4013930 200 µM 0.00771324044567949 0.47335881648033 no 1773 0.496922892778956 2394 64556
SGTC_823 0417-1665 178 µM 0.00588343994616922 0.47268229794386 no 1774 0.497652860592264 2390 3429856
SGTC_642 0335-0876 158 µM 0.00514708866714724 0.472410074384214 no 1775 0.497946617776249 2391 6812350
SGTC_703 3875-0075 71.8 µM 0.000143808102751797 0.470560746728663 no 1776 0.499942628867746 2404 2850814
SGTC_251 melphalan 456.522 µM 1.43803488145181e-05 0.470512915502381 no 1777 0.499994263070851 2401 460612 A DNA alkylator.
SGTC_667 1498-1044 59 µM -0.00222758434081148 0.46968444477068 no 1778 0.499111323158246 2409 6739982
SGTC_1468 k284-1086 134 µM -0.00326310764200121 0.469301833075999 no 1779 0.498698210706319 2414 15996457
SGTC_2166 5933061 31.504 µM -0.00363258751675571 0.469165322159594 no 1780 0.498550810439485 2414 2877375
SGTC_1768 st044301 37.178 µM -0.00398699157052367 0.469034384679292 no 1781 0.498409424704906 2414 3931349
SGTC_318 1488-0629 67.2 µM -0.00403778885274873 0.46901561748142 no 1782 0.498389159684426 2420 3662576
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.00404339554791284 0.469013546076441 no 1783 0.498386922954931 2410 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2837 9008476 45.46 µM -0.00689044875649925 0.467961806023767 no 1784 0.497251130412045 2431 2992805
SGTC_2813 7971799 71.43 µM -0.00743911579041634 0.467759146453064 no 1785 0.497032249555197 2424 2234054
SGTC_1359 1582-0056 520 nM -0.00817517856827483 0.467487282186867 no 1786 0.496738611947678 2425 3661189
SGTC_2948 9070189 9.45 µM -0.00873513577297877 0.467280472539337 no 1787 0.496515229331343 2421 6473636 YDL196W YDL196W
SGTC_383 2324-0395 7.37 µM -0.0108301471648231 0.466506798325936 no 1788 0.495679480853599 2440 3146421
SGTC_445 e6 berbamine 66 µM -0.0112445639932931 0.466353771759426 no 1789 0.495514162530307 2445 6610268 A calcium/calmodulin antagonist.
SGTC_1734 st037168 69.4 µM -0.0125280876033437 0.465879852560972 no 1790 0.495002146900784 2457 708907
SGTC_1035 k081-0041 55.2 µM -0.0129783596862194 0.465713608704292 no 1791 0.494822528938308 2429 731709
SGTC_489 paxilline 115 µM -0.0142837071447956 0.465231698472563 no 1792 0.494301819060948 2455 105008 A toxic potassium channel blocker.
SGTC_571 k831-0106 44.2 µM -0.0148082384339671 0.465038065505554 no 1793 0.494092583491461 2432 4783639
SGTC_1679 SEC14.276 6.7 µM -0.0157674740527873 0.464683981022379 no 1794 0.493709948577966 2448 1005053 YMR079W SEC14
SGTC_827 3253-0474 693 µM -0.017332716435248 0.464106260271901 no 1795 0.493085592789398 2446 5402065
SGTC_2598 perillyl alcohol 100 µM -0.0174587278742268 0.464059753547017 no 1796 0.49303532910436 2452 10819 An apoptosis inducer.
SGTC_525 k781-2675 26.7 µM -0.0185695799680014 0.463649795475357 no 1797 0.492592235159643 2433 3651118 YDL195W SEC31
SGTC_1019 4262-0212 3.4 µM -0.0188073645446654 0.463562046482931 no 1798 0.492497389402921 2429 4677213
SGTC_1243 0416-0003 5.65 µM -0.0188368188602372 0.463551177160663 no 1799 0.492485640912359 2451 2141977
SGTC_1353 1498-1206 8.11 µM -0.0202052071763733 0.463046240417312 no 1800 0.491939837004263 2436 6756808
SGTC_834 0312-0008 75.7 µM -0.0208986886218812 0.462790367705948 no 1801 0.49166323636233 2445 6385573 YIL048W NEO1
SGTC_582 0987-0078 156 µM -0.0211789319462686 0.462686971148046 no 1802 0.491551460192364 2443 1625765
SGTC_2022 5136654 200 µM -0.0227328419582752 0.462113697641237 no 1803 0.490931689252671 2487 1713771
SGTC_1510 1123-0200 71.5 µM -0.0229492545804453 0.462033864212944 no 1804 0.490845375626271 2453 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1628 st004252 77.7 µM -0.0239594828970726 0.4616612168197 no 1805 0.490442463692701 2463 692968
SGTC_45 0kpi-0036 14.9 µM -0.0245377947969685 0.461447907474865 no 1806 0.490211818447053 2460 2795021
SGTC_2568 diosmetin 100 µM -0.0264156362837533 0.460755345673689 no 1807 0.489462911275505 2454 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2743 auranofin 4.32 µM -0.0278647329414621 0.460220989380979 no 1808 0.488885018275092 2468 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2975 9084847 53.72 µM -0.0281308133262382 0.46012287966773 no 1809 0.488778909156242 2541 27211724
SGTC_2284 7945075 39.21 µM -0.0285253509902668 0.459977409389798 no 1810 0.488621574543495 2484 1245402
SGTC_2900 5328528 85.29 µM -0.0298636879765496 0.459483990179568 no 1811 0.488087882860564 2450 795359
SGTC_3244 9134489 49.47 µM -0.0312519170575496 0.4589722426516 no 1812 0.487534318143679 2497 16584271
SGTC_369 0957-0393 4.5 µM -0.0327665633187 0.458413971113087 no 1813 0.486930371246637 2472 6997992
SGTC_48 0382-0018 55 µM -0.033814303620526 0.458027840690556 no 1814 0.486512614914451 2459 762596
SGTC_876 0720-0963 56.8 µM -0.0353961860118581 0.457444934633232 no 1815 0.485881912964763 2467 765861
SGTC_3080 9117754 49.47 µM -0.0375145792839724 0.456664473867372 no 1816 0.485037357871028 2467 9550191
SGTC_1742 st038235 28.8875 µM -0.0381866141428736 0.456416916828398 no 1817 0.484769446739509 2531 564103 YBR002C RER2
SGTC_344 k064-0035 6.43 µM -0.0383600106818545 0.456353045600869 no 1818 0.484700322175901 2477 5088750
SGTC_2235 salicylic acid 500 µM -0.0390293210583215 0.456106513352614 no 1819 0.484433505796819 2464 338 A COX inhibitor and kinase inhibitor.
SGTC_2376 9072922 81.32 µM -0.0395964742313763 0.455897622676021 no 1820 0.484207419196036 2583 17087968
SGTC_2493 resveratrol 26.09 µM -0.0404320018837937 0.45558990803975 no 1821 0.483874358643643 2463 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3306 9127676 59.7925 µM -0.0405906754722293 0.455531473498134 no 1822 0.483811108963493 2525 41905287
SGTC_1154 4088-0362 150 µM -0.0427116972299688 0.454750460104255 no 1823 0.482965677519408 2476 6618304
SGTC_2153 5569715 200 µM -0.0432650785824626 0.45454671985986 no 1824 0.482745114198383 2481 2054701
SGTC_3264 9137442 49.47 µM -0.0440498873556149 0.454257794733143 no 1825 0.482432319036853 2506 17015726
SGTC_3355 9151058 44.0485 µM -0.0449983061524675 0.453908669349915 no 1826 0.482054329541436 2485 17015728
SGTC_2849 9019321 12.99 µM -0.0457449750687652 0.453633835781942 no 1827 0.481756758193924 2551 16489627
SGTC_2339 9000433 200 µM -0.0458425184719888 0.453597933685723 no 1828 0.481717884787669 2530 2988954
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0470682725637868 0.453146811645611 no 1829 0.481229407062916 2507 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1055 3448-0672 86 µM -0.0483287160801394 0.452682985692189 no 1830 0.480727134582211 2573 748378
SGTC_2000 st075254 36.4 µM -0.0488574528526702 0.452488436984414 no 1831 0.480516448023601 2496 17234175
SGTC_974 1326-0144 138 µM -0.0495448143625324 0.452235539359953 no 1832 0.480242562166292 2506 5411856
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.0497139372453333 0.45217331775522 no 1833 0.480175174938859 2515 2374 Ca(2+)-ATPase inhibitor.
SGTC_1677 st019204 53.9 µM -0.0546999057090361 0.450339475981376 no 1834 0.478188772242586 2609 3945625
SGTC_539 4859-0462 2.54 µM -0.0550257155229287 0.450219679428777 no 1835 0.478058988400086 2505 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1787 fluconazole 80 µM -0.0556951410924421 0.449973553527246 no 1836 0.47779233517138 2527 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1472 k841-0093 193 µM -0.0557226910954937 0.449963424703194 no 1837 0.477781361352089 2591 X1472
SGTC_996 3970-0799 1.8 µM -0.0558099325580625 0.449931350387356 no 1838 0.477746611120661 2480 6615648 YGL040C HEM2
SGTC_3048 9093155 49.47 µM -0.0565731370097855 0.449650772308455 no 1839 0.477442616911808 2503 25236002
SGTC_1428 4049-0204 61.7 µM -0.056859810168154 0.449545388689806 no 1840 0.477328434664786 2550 X1428
SGTC_2497 7-hydroxyflavone 100 µM -0.0578245517077903 0.449190767246448 no 1841 0.476944190730602 2566 5281894
SGTC_120 rhodamine 6G 52.259 µM -0.0594589651857688 0.448590079338013 no 1842 0.476293274329482 2519 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2402 5553605 200 µM -0.0601240832137948 0.448345665452267 no 1843 0.476028404513216 2559 6758546
SGTC_1814 st052110 31.539 µM -0.061267545929923 0.447925517990117 no 1844 0.475573068412365 2535 674163
SGTC_1773 st048542 73.5835 µM -0.0616996689622899 0.447766756334534 no 1845 0.475401001799335 2514 3237138
SGTC_1524 corynanthine 62.1 µM -0.06199343034998 0.447658833412249 no 1846 0.475284031880628 2693 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2572 astragaloside iv 100 µM -0.0652973367523356 0.446445303276584 no 1847 0.473968631392382 2675 45006101 An anti-inflammatory agent.
SGTC_764 1951-2361 146 µM -0.0655084433315788 0.446367780412295 no 1848 0.473884591985635 2527 5438930
SGTC_252 miconazole 1.30953 nM -0.0693887878596185 0.444943202800425 no 1849 0.472340076700258 2534 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_873 0591-4978 488 µM -0.0712387299600215 0.444264288955171 no 1850 0.471603878826314 2561 3305145
SGTC_1808 st050063 61.5 µM -0.0738299147318996 0.443313620360056 no 1851 0.470572861730636 2523 4011993
SGTC_1987 st072290 61.9 µM -0.0738338784613873 0.443312166372937 no 1852 0.470571284735436 2593 54697379
SGTC_1797 st048695 56.8 µM -0.073888541387313 0.44329211483262 no 1853 0.470549536786829 2529 592262 YIL048W NEO1
SGTC_2163 5671233 125 µM -0.0745705210274666 0.443041962213699 no 1854 0.470278214805089 2558 701023
SGTC_180 1486-1293 102.781 µM -0.0745761718385904 0.443039889570265 no 1855 0.470275966717327 2558 4140536
SGTC_1446 4239-0190 62 µM -0.0750784683336194 0.44285566003476 no 1856 0.47007613962279 2554 1340085
SGTC_2666 tannic acid 100 µM -0.0751984123964868 0.442811669439357 no 1857 0.470028423751933 2553 16134267 A thiamine antagonist.
SGTC_2008 4012253 172 µM -0.0754951411272774 0.442702844460985 no 1858 0.469910381662396 2561 603940
SGTC_2358 9037157 4 µM -0.077090242099134 0.442117916984 no 1859 0.469275877788571 2604 2388925
SGTC_2924 9010168 62.78 µM -0.0774925358449247 0.441970414745339 no 1860 0.469115864476312 2627 2993929
SGTC_1516 st013856 110 µM -0.0776950528503439 0.441896164306075 no 1861 0.469035314732669 2686 5281404 A mutagen and neurotoxin.
SGTC_1467 k284-1082 293 µM -0.0782596392349446 0.441689176244166 no 1862 0.468810761090165 2556 3334705
SGTC_210 3551-0445 56.827 µM -0.0794662987519286 0.441246845462787 no 1863 0.46833086825757 2656 2865180 YOR207C RET1
SGTC_3219 9131112 49.47 µM -0.0796222665673962 0.441189676952764 no 1864 0.468268842639512 2554 17612988 YMR079W SEC14
SGTC_15 0266-0086 27.098 µM -0.0804109143916986 0.440900624428459 no 1865 0.467955223293131 2555 1712902 YIL048W NEO1
SGTC_1518 st038567 90.8 µM -0.0819065492920528 0.440352535990911 no 1866 0.467360513179697 2537 77966
SGTC_1432 4049-0298 68.4 µM -0.0826556191059461 0.440078075711798 no 1867 0.467062687441649 2587 741646
SGTC_1423 4048-0112 5.59 µM -0.0826780020191323 0.440069875021918 no 1868 0.467053788410335 2595 X1423
SGTC_2781 5567276 71.43 µM -0.0858701924611065 0.438900579823705 no 1869 0.465784803467135 2673 2853274
SGTC_1670 st016595 4.04 µM -0.0868507573710979 0.438541506714349 no 1870 0.465395070733599 2546 597879
SGTC_2700 st077718 96.8 µM -0.0874924984591028 0.438306534881956 no 1871 0.465140023964635 2616 904970
SGTC_558 k064-0027 21.3 µM -0.0884406564936426 0.437959409104713 no 1872 0.464763224334272 2639 5088526
SGTC_838 0109-0203 71.4 µM -0.0904174911006448 0.437235833091593 no 1873 0.463977728867338 2568 759422
SGTC_278 4092-0821 23.9 µM -0.0905832131340012 0.43717518375613 no 1874 0.463911885533156 2650 877900
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0908443763481153 0.437079608784132 no 1875 0.46380812429 2553 1241132 A phosphatase inhibitor.
SGTC_19 0279-0214 38.434 µM -0.0909092275434477 0.437055876488519 no 1876 0.463782359018664 2575 3566274 YBR002C RER2
SGTC_1411 3909-8223 150 µM -0.0911148532823064 0.436980629245299 no 1877 0.463700665261761 2580 X1411
SGTC_1990 st072050 59.8 µM -0.0925028712424593 0.436472753940301 no 1878 0.463149255041144 2554 17233948
SGTC_2183 6420625 130.508 µM -0.0925600838174669 0.43645182211955 no 1879 0.463126528029746 2559 2897619
SGTC_807 1315-0151 48 µM -0.0949818486269464 0.435565957975198 no 1880 0.46216462221423 2584 4011080
SGTC_891 0929-0073 133 µM -0.095656198150067 0.435319343114414 no 1881 0.461896815060274 2728 5603632
SGTC_685 1278-0033 54.9 µM -0.0964230986125185 0.435038912231586 no 1882 0.461592273777592 2590 3590572
SGTC_2518 prenyletin 46.28 µM -0.0969590713243508 0.434842943602532 no 1883 0.461379448801168 2601 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_976 1348-1067 47.6 µM -0.0983170536287002 0.434346493943532 no 1884 0.460840268474689 2581 5310671 YGL099W LSG1
SGTC_170 4197-0004 226 µM -0.0986816792533312 0.434213212110501 no 1885 0.460695507846244 2691 218692
SGTC_1692 fluoroquinolonic acid 71 µM -0.0989826901452666 0.434103189044645 no 1886 0.460576006933111 2687 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0999161997687031 0.433762012659581 no 1887 0.460205427577605 2636 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1514 1189-1591 158 µM -0.100139205660519 0.433680516406648 no 1888 0.460116905066193 2742 767698 YMR146C TIF34
SGTC_1451 4152-0210 104 µM -0.100407325764881 0.433582537150579 no 1889 0.46001047702038 2572 659563
SGTC_2689 tacrolimus 100 µM -0.101051420970341 0.433347181826337 no 1890 0.459754820507722 2674 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_285 1486-1325 46 µM -0.101477661082483 0.433191444736971 no 1891 0.459585644940214 2664 22310230
SGTC_1033 k072-0102 21.3 µM -0.102088486795606 0.432968282945296 no 1892 0.459343219736562 2575 5965931
SGTC_822 1487-0950 154 µM -0.102336641390605 0.432877627140157 no 1893 0.459244736171804 2588 1958375
SGTC_3180 9109287 49.47 µM -0.102369464803006 0.432865636359733 no 1894 0.459231709936209 2686 18891271
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.103277197035965 0.432534055579144 no 1895 0.458871486479624 2662 6728940
SGTC_2243 6634756 200 µM -0.103539380054889 0.432438292941315 no 1896 0.458767448332382 2848 885676
SGTC_3169 9102970 49.47 µM -0.104670572576355 0.432025169189613 no 1897 0.458318606672486 2576 17027839
SGTC_2449 5812982 45.77 µM -0.105384387064734 0.431764514629825 no 1898 0.458035402196021 2584 776185
SGTC_2279 7948423 32.93 µM -0.106347819644937 0.431412757328087 no 1899 0.457653196045459 2581 1247112
SGTC_1753 st043925 64 µM -0.106655160563059 0.431300556014374 no 1900 0.45753127815451 2613 670181
SGTC_570 0987-0065 62.6 µM -0.106697662112888 0.431285040359234 no 1901 0.457514418691869 2578 3104428
SGTC_3214 9129694 49.47 µM -0.106931364705211 0.431199726569588 no 1902 0.457421715201107 2650 17158655
SGTC_549 1661-1316 519 µM -0.107051586945321 0.431155840352264 no 1903 0.457374027195614 2635 2857282
SGTC_3211 9128781 49.47 µM -0.107964053794223 0.430822778991452 no 1904 0.457012103204091 2747 17194361
SGTC_3151 9099821 49.47 µM -0.109189999079988 0.430375371726257 no 1905 0.456525896229529 2710 17174189
SGTC_2114 5491910 81.25 µM -0.109756935133172 0.430168499276935 no 1906 0.456301072707041 2699 2849228
SGTC_1569 carminic acid 40.6 µM -0.110872801413916 0.429761380665414 no 1907 0.455858606963332 2636 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2130 NSC 7 2.4545 µM -0.111439242745325 0.429554745734336 no 1908 0.455634021316497 2675 21448
SGTC_553 k007-0256 45.7 µM -0.111596708286421 0.429497306527503 no 1909 0.455571591063349 2656 6287000
SGTC_2036 5160441 105 µM -0.114111726212154 0.42858009852728 no 1910 0.454574613386431 2637 134534 YIL048W NEO1
SGTC_1688 st021091 57.6 µM -0.114553482515503 0.428419033022082 no 1911 0.4543995262335 2591 3656366
SGTC_2818 7996756 12.99 µM -0.114966290118576 0.428268533064479 no 1912 0.454235920711553 2602 2241621
SGTC_2332 7982454 138.89 µM -0.116614216279305 0.427667842049135 no 1913 0.453582885815216 2600 2981748
SGTC_1698 5-fluorocytosine 1.055 µM -0.118009490685648 0.427159376943524 no 1914 0.453030068976216 2621 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1605 st000082 49.1 µM -0.118305602840035 0.427051483455205 no 1915 0.452912759077189 2741 1114022
SGTC_1105 epirubicin 18.1 µM -0.118325398599775 0.427044270728732 no 1916 0.452904916794525 2618 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1034 k072-0165 12.7 µM -0.118953572841326 0.426815403636246 no 1917 0.452656069018194 2690 5835461
SGTC_1486 3970-0793 4.53 µM -0.119478164843293 0.426624294256048 no 1918 0.452448269021002 2706 2844330
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.119805476944967 0.42650506286044 no 1919 0.452318621611016 2614 3256 An antibiotic and ribosome inhibitor.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.12110958311555 0.426030077256316 no 1920 0.451802119411515 2599 6708630 An antioxidant.
SGTC_683 panaxydol 45 µM -0.121534254079714 0.425875425402537 no 1921 0.45163394247436 2691 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_657 3534-0529 86.7 µM -0.123311020338259 0.425228506722557 no 1922 0.450930407233747 2744 1049549
SGTC_2947 9072639 7.68 µM -0.123756176647785 0.425066457252951 no 1923 0.450754165478556 2682 16488146
SGTC_720 r052-1644 49.9 µM -0.124138374751367 0.424927336448689 no 1924 0.450602857240595 2729 1422863 YOR257W CDC31
SGTC_1632 st005650 90 µM -0.124399403447419 0.424832326901119 no 1925 0.450499522830045 2744 2759605
SGTC_621 3584-0052 32.1 µM -0.12460290579612 0.424758258893319 no 1926 0.450418963918058 2628 2273927
SGTC_2861 9024595 19.48 µM -0.125238886251588 0.42452680054096 no 1927 0.450167216401321 2593 16482810
SGTC_1234 0326-0494 15.5 µM -0.126101747822021 0.424212812827626 no 1928 0.449825691977694 2738 1547813
SGTC_627 1391-0720 175 µM -0.126835702101386 0.423945771187052 no 1929 0.449535218866233 2708 997839
SGTC_1443 4112-3303 14 µM -0.127661937040153 0.423645195972571 no 1930 0.449208256698124 2643 704433
SGTC_111 0083-0039 52.457 µM -0.128944590101417 0.423178668916552 no 1931 0.448700746679632 2615 759313
SGTC_3248 9135562 49.47 µM -0.129547995624159 0.422959235240282 no 1932 0.448462024934072 2661 17650701
SGTC_966 1300-0360 30.2 µM -0.131548505062588 0.422231903881439 no 1933 0.447670709215724 2654 70588
SGTC_2731 amoxapine 43.43 µM -0.131661272555462 0.422190912528414 no 1934 0.447626109403148 2621 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3133 9127736 49.47 µM -0.131775809533412 0.42214927882453 no 1935 0.447580810432845 2607 27243420
SGTC_830 4076-0286 57.8 µM -0.13190423550994 0.422102597563373 no 1936 0.447530019225768 2670 6866659
SGTC_2461 5755302 26.15 µM -0.132680496813488 0.421820459458725 no 1937 0.447223033883334 2811 2788904
SGTC_1837 st055472 66.5 µM -0.132876514395156 0.421749221709713 no 1938 0.447145520488574 2787 676091
SGTC_2436 5633522 8.09 µM -0.133202449680576 0.421630774249783 no 1939 0.447016636773894 2683 5724242
SGTC_216 k038-0035 28.382 µM -0.133247196622534 0.421614513410544 no 1940 0.446998943047315 2618 4444231 YPR107C YTH1
SGTC_3056 9094900 49.47 µM -0.134100922650855 0.421304298811089 no 1941 0.446661385032175 2696 25236784
SGTC_1811 st050069 61.5 µM -0.134317763671878 0.421225514032271 no 1942 0.446575653572068 2645 3877702
SGTC_1763 st044482 94.5 µM -0.134766876553977 0.42106234802707 no 1943 0.446398097775829 2772 88505
SGTC_76 0433-0009 400.328 µM -0.134923773092536 0.421005349557414 no 1944 0.446336071603332 2805 2841569
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.135740695809256 0.420708598951174 no 1945 0.446013137422138 2662 688669
SGTC_2736 butenafine 14.65 µM -0.135922305907263 0.420642634435826 no 1946 0.445941350778462 2676 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1006 4099-6547 255 µM -0.136548728198059 0.420415122111711 no 1947 0.445693752862876 2740 3146833
SGTC_1108 betulinic acid 729.144 nM -0.136849805873502 0.420305782198515 no 1948 0.445574757275959 2666 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_2262 9014885 67.46 µM -0.13733103808981 0.420131029809727 no 1949 0.445384569001978 2685 6457424
SGTC_1816 st051957 91.6 µM -0.139410058961927 0.419376245373312 no 1950 0.444563062039222 2651 674121
SGTC_1278 0874-0585 172 µM -0.140440015161731 0.419002431480512 no 1951 0.444156171798067 2706 766306
SGTC_1676 st018489 23.4 µM -0.140537097983897 0.418967199856472 no 1952 0.444117821687915 2726 3696235
SGTC_1369 1866-0067 208 µM -0.141352506121834 0.418671311670229 no 1953 0.443795736041876 2683 3531355
SGTC_3069 9117009 49.47 µM -0.142262594783021 0.418341120977649 no 1954 0.443436295501934 2675 41904981
SGTC_1881 5652484 16 µM -0.142293257763893 0.418329997094164 no 1955 0.443424185931865 2710 2255129
SGTC_2254 7938975 95.19 µM -0.144204724139494 0.417636686665075 no 1956 0.442669405307421 2848 2969277
SGTC_1367 1812-0510 76.9 µM -0.144747829165351 0.417439742940273 no 1957 0.442454987286918 2706 1142582 YDR527W RBA50
SGTC_2355 9061122 103.12 µM -0.145170618543099 0.417286443069205 no 1958 0.442288081583741 2791 5302957
SGTC_654 1124-0271 80.9 µM -0.146161541635714 0.416927191998865 no 1959 0.441896932393164 2699 5403748
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.146658271791494 0.41674713261866 no 1960 0.441700878328979 2785 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1153 4055-0057 267 µM -0.149423561374654 0.415745064910904 no 1961 0.440609710571546 2675 882706
SGTC_2746 daunorubicin 9.88 µM -0.149457499113413 0.415732770161573 no 1962 0.440596321713612 2637 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2031 5180455 200 µM -0.15000212102494 0.415535479271397 no 1963 0.440381470929392 2668 29949
SGTC_277 nystatin 15.5 µM -0.153246273105777 0.414360718412789 no 1964 0.439102033970113 2638 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2455 5377712 9.75 µM -0.153272745738291 0.414351135372297 no 1965 0.439091596223764 2749 2243908
SGTC_1941 st076221 61.8 µM -0.154436961045647 0.413929742243373 no 1966 0.438632606263461 2842 2828568
SGTC_730 1436-0052 41.2 µM -0.154882441838561 0.413768524588797 no 1967 0.4384569979928 2670 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_475 α-linolenic acid 10 µM -0.155363628514774 0.413594401450906 no 1968 0.438267328096281 2914 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2984 9022109 38.96 µM -0.1558903980663 0.413403803086944 no 1969 0.438059707005155 2657 6459207
SGTC_99 0109-0120 622.8 µM -0.156226244212505 0.413282296222248 no 1970 0.437927345412026 2708 759414
SGTC_279 1273-0055 2.93 µM -0.156361288672092 0.41323344039049 no 1971 0.437874124486827 2755 2847562
SGTC_25 0118-0223 35.662 µM -0.156825545514768 0.413065493703928 no 1972 0.437691169774567 2756 5333628
SGTC_1977 st070720 65.3 µM -0.157410976571006 0.412853734465277 no 1973 0.437460481623505 2791 682188
SGTC_1892 st058411 7.36 µM -0.157709940974631 0.412745604310533 no 1974 0.43734268338369 2820 3934738
SGTC_2855 9016525 58.44 µM -0.157995961287675 0.412642162001917 no 1975 0.437229990585185 2669 43811474
SGTC_2508 celastrol 40.54 µM -0.158024383592781 0.412631883102226 no 1976 0.437218792395977 2663 122724 Celastrol is a natural product and antioxidant.
SGTC_2953 9074162 66.49 µM -0.159629819796487 0.412051376097173 no 1977 0.436586343693414 2773 16451992
SGTC_3176 9106582 49.47 µM -0.160370035631155 0.411783787411652 no 1978 0.43629479609852 2691 17018027
SGTC_1940 st075990 51.1 µM -0.160828191067315 0.411618184355648 no 1979 0.436114360498508 2943 1084979
SGTC_2109 5483026 200 µM -0.160899386162611 0.411592451869954 no 1980 0.436086322888678 2724 759335
SGTC_1976 st070609 63.5 µM -0.160940500263863 0.411577591918052 no 1981 0.4360701317352 2617 682556
SGTC_597 k018-0003 82.8 µM -0.163320533803234 0.410717588477571 no 1982 0.435133033662524 2810 6786234
SGTC_3081 9117243 49.47 µM -0.163368945819149 0.410700099675035 no 1983 0.435113976009388 2887 45595589
SGTC_980 1473-0395 201 µM -0.163416759408065 0.410682827228038 no 1984 0.435095154078236 2698 768876
SGTC_1550 gossypolone 36.6 µM -0.164010583647535 0.410468325298546 no 1985 0.434861406045553 2697 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1401 3807-4679 7.6 µM -0.164024426627494 0.410463325239287 no 1986 0.434855957281314 2686 3291456
SGTC_1139 k015-0024 46.9 µM -0.164756755679181 0.410198830082636 no 1987 0.434567721379337 2679 2766652
SGTC_812 4251-0442 148 µM -0.164975225567543 0.410119933255712 no 1988 0.434481740988067 2691 5723007
SGTC_2512 diallyl trisulfide 49.23 µM -0.166074179841138 0.409723119135634 no 1989 0.43404928673371 2691 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1065 prochlorperazine maleate 2.48 µM -0.16682317435687 0.40945272261902 no 1990 0.433754591851237 2713 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2391 6285546 200 µM -0.167083266417952 0.4093588361554 no 1991 0.433652266196129 2672 846083
SGTC_250 brefeldin a 552.239 µM -0.168042116141498 0.40901276131397 no 1992 0.433275073131849 2694 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2621 lithochol-11-enic acid 100 µM -0.169339436071525 0.408544636333211 no 1993 0.432764829187889 2710 6708711
SGTC_1371 2421-0008 32.7 µM -0.171003357394838 0.407944417941004 no 1994 0.432110562831544 2759 2827552
SGTC_2399 5884133 200 µM -0.171719030404551 0.407686322974619 no 1995 0.431829211975362 2742 722445
SGTC_1842 st055362 61.2 µM -0.171953934950001 0.407601617481704 no 1996 0.43173687203066 2726 676032
SGTC_2065 5221596 34.26 µM -0.173167237281367 0.407164175130849 no 1997 0.431259987708679 2838 788581
SGTC_2757 clomiphene 4.22 µM -0.17371973512961 0.406965016646426 no 1998 0.431042863480069 2875 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1867 st057372 64 µM -0.173996352007998 0.406865313801347 no 1999 0.430934164588998 2729 688837
SGTC_439 amiodarone 34.4 µM -0.174233397054117 0.406779878894828 no 2000 0.430841019939026 2781 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1875 nocodazole 6 µM -0.17429167565981 0.406758875012687 no 2001 0.430818120490977 2713 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1666 st014829 29 µM -0.174304805124667 0.406754143129144 no 2002 0.43081296155445 2682 3858230
SGTC_51 1013-0126 23.419 µM -0.175812788578419 0.40621075383169 no 2003 0.430220511152353 2870 1627850
SGTC_2840 9008771 71.43 µM -0.175977085573852 0.406151561667362 no 2004 0.430155972281636 2882 2992978
SGTC_1602 st001878 87.6 µM -0.176451851613291 0.405980527206208 no 2005 0.429969485973351 2913 595405 YLR310C CDC25
SGTC_1899 st063254 59.6 µM -0.178258261585466 0.40532993231117 no 2006 0.429260078099983 2698 3093813
SGTC_1212 0520-0165 585 µM -0.179084137523346 0.405032572617668 no 2007 0.428935818539888 3138 5403258
SGTC_425 3825-7017 13.1 µM -0.179280379490784 0.404961923024373 no 2008 0.428858776075922 2980 3397440
SGTC_1629 st005085 44.9 µM -0.179866039151677 0.404751096554921 no 2009 0.428628868583395 2729 24207091
SGTC_1456 k015-0012 13 µM -0.180449514437228 0.404541083911636 no 2010 0.428399842674576 2722 2989616
SGTC_1638 st008370 60.6 µM -0.182129512824814 0.403936549008113 no 2011 0.427740544088317 2697 24207134
SGTC_2964 9083345 53.42 µM -0.182674648304154 0.403740435287239 no 2012 0.427526654370466 2775 17741579
SGTC_1515 3460-0031 42.1 µM -0.183210098596327 0.403547829390012 no 2013 0.427316585473069 2759 2876596
SGTC_2236 dapsone 200 µM -0.184823584206725 0.40296758688797 no 2014 0.426683704507596 2760 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1339 1486-1321 22.7 µM -0.185890669561464 0.402583958392165 no 2015 0.426265249643743 2746 3469382
SGTC_253 dyclonine 31.25 µM -0.186013533554927 0.402539793498219 no 2016 0.42621707415432 2713 3180 An oral anasthetic.
SGTC_1998 st075797 76.8 µM -0.188225350620777 0.401744943353242 no 2017 0.425350000361728 2685 24208315
SGTC_1382 3002-2117 298 µM -0.189920432381785 0.401136064714005 no 2018 0.424685740568752 2861 1497314
SGTC_1255 0566-0045 221 µM -0.190836292560791 0.40080718467524 no 2019 0.424326926915257 2885 2788469
SGTC_394 menadione 8.33 µM -0.190957333203391 0.400763724941654 no 2020 0.424279510568001 2745 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_102 gallobenzophenone 83.616 µM -0.191908407085253 0.400422283932938 no 2021 0.423906975972724 2906 70837
SGTC_2747 doxorubicin 7.63 µM -0.192711345880158 0.40013408349408 no 2022 0.423592518644023 2735 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2054 5233173 129 µM -0.194212412298512 0.399595448667617 no 2023 0.42300478215052 2903 6889
SGTC_1484 3473-2379 286 µM -0.197332303550556 0.398476535446702 no 2024 0.421783750868495 2745 671917
SGTC_1384 3089-0840 101 µM -0.198688635906031 0.397990361979411 no 2025 0.421253157014526 2849 1069836
SGTC_152 4469-0003 551.229 µM -0.200432197373527 0.39736562004522 no 2026 0.42057129024514 2757 697280
SGTC_3327 9140648 26.9345 µM -0.200544120652654 0.397325525375983 no 2027 0.420527527742609 2877 8029710
SGTC_1499 4480-0877 67.3 µM -0.200665381913574 0.397282086753221 no 2028 0.420480115156074 2762 2861909
SGTC_515 4092-1064 102 µM -0.200982451212765 0.397168511128808 no 2029 0.420356147995126 2981 717353
SGTC_2167 5876490 200 µM -0.202273797047767 0.396706035513841 no 2030 0.419851341748111 2995 686534
SGTC_596 1155-0152 116 µM -0.202610857362542 0.396585346434905 no 2031 0.419719601534553 2761 280313
SGTC_3047 9092122 49.47 µM -0.202963143126122 0.396459216263324 no 2032 0.41958192006126 2827 17173831
SGTC_2119 5528445 120.635 µM -0.203184763607735 0.39637987421595 no 2033 0.419495310663727 2896 791935
SGTC_2936 9038235 15.59 µM -0.205007175127151 0.395727598155639 no 2034 0.418783259572978 2748 4749415
SGTC_590 k048-0076 22.4 µM -0.205102190221489 0.395693598420888 no 2035 0.418746142631027 2884 6832814
SGTC_1162 k048-0130 20.1 µM -0.205467548937361 0.395562867648417 no 2036 0.418603424699314 2771 6797406
SGTC_73 0327-0325 16.231 µM -0.206524765147009 0.395184646235679 no 2037 0.41819051095109 2938 53298
SGTC_3353 9151644 39.2805 µM -0.206618740106829 0.395151031260885 no 2038 0.418153811790454 2886 4909158
SGTC_1100 amiodarone 5.07 µM -0.207070020639813 0.394989618456453 no 2039 0.417977587364481 2880 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1891 st059073 26.2 µM -0.208766413531249 0.394383018622119 no 2040 0.417315295854256 2969 688754
SGTC_1106 tegaserod maleate 11.7 µM -0.209302011895067 0.394191551315143 no 2041 0.417106240647701 2822 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1247 0448-0043 5.84 µM -0.210543792454231 0.393747734308308 no 2042 0.416621638056051 2909 3089013 YGL099W LSG1
SGTC_2064 5220758 200 µM -0.211012586996 0.393580221236177 no 2043 0.416438724744978 2925 788518
SGTC_1477 0139-0234 16 µM -0.211293471697901 0.393479862906496 no 2044 0.416329138382769 2766 620880
SGTC_805 3852-0218 479 µM -0.211469028720346 0.393417141084521 no 2045 0.416260648615345 2768 6615355
SGTC_2983 9022671 12.99 µM -0.211810727661622 0.393295069137085 no 2046 0.416127349471574 2985 6405161
SGTC_2652 actinonin 100 µM -0.211869264647553 0.393274157850841 no 2047 0.416104514751971 2758 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2980 9014342 25.29 µM -0.212322965605205 0.393112091783088 no 2048 0.415927539947467 2955 2996599
SGTC_663 1486-0733 13.9 µM -0.212542304777508 0.393033748495946 no 2049 0.415841988585839 2783 722445 YPR165W RHO1
SGTC_2885 9057732 51.95 µM -0.213211852662416 0.392794627041393 no 2050 0.415580861865091 2933 6471414
SGTC_3229 9132204 49.47 µM -0.213486112498368 0.392696689917186 no 2051 0.415473910036496 2778 17682924
SGTC_1314 1222-0010 41.1 µM -0.214791986052394 0.392230460818135 no 2052 0.414964750642571 2827 3526027
SGTC_3228 9131799 49.47 µM -0.21494522766957 0.392175759904273 no 2053 0.41490501116428 2847 17015818
SGTC_2899 9053889 58.44 µM -0.214959859711519 0.392170536982414 no 2054 0.414899307134256 2841 6470052
SGTC_950 1165-0508 94.1 µM -0.215601242197447 0.391941613970948 no 2055 0.414649293719981 2876 6148369
SGTC_3276 9139060 49.47 µM -0.215816424987791 0.39186481904499 no 2056 0.414565422362276 2766 4870619
SGTC_1641 st009299 47.1 µM -0.216260410282974 0.391706381874868 no 2057 0.414392383431435 2797 4046054
SGTC_412 gemfibrozil 100 µM -0.21699501434342 0.391444276184941 no 2058 0.414106115177142 2812 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1778 st046819 58.9 µM -0.217103686766608 0.391405506199515 no 2059 0.414063770432436 2803 671715
SGTC_1192 1488-0095 21.4 µM -0.217259774419847 0.391349822239113 no 2060 0.414002951857996 2862 915875
SGTC_557 1315-0110 16.2 µM -0.21812226665775 0.391042170020079 no 2061 0.413666924393435 2797 6833801
SGTC_2898 9056270 58.44 µM -0.21886339168667 0.390777864106821 no 2062 0.413378232147471 2759 19154699
SGTC_675 1309-0189 238 µM -0.220424745069414 0.390221207058726 no 2063 0.412770187757628 2833 4246530
SGTC_1364 1653-0028 37.6 µM -0.220803158823594 0.390086328009164 no 2064 0.412622851949872 2860 5718652
SGTC_1357 1503-1303 39.5 µM -0.221847880461101 0.389714023753388 no 2065 0.412216152408982 2815 292895
SGTC_3168 9103419 49.47 µM -0.223677128734648 0.389062383992304 no 2066 0.411504271845427 2806 16649256
SGTC_356 1634-0012 32.5 µM -0.223783159148459 0.389024621939518 no 2067 0.411463017359633 2872 735457
SGTC_2895 9054447 58.44 µM -0.223791770441262 0.38902155512876 no 2068 0.411459666906801 2810 2697450
SGTC_1969 st069479 40.1 µM -0.224969424091229 0.388602212826875 no 2069 0.411001530307508 2986 3895485
SGTC_371 0195-0006 7.36 µM -0.226465530729857 0.388069662095597 no 2070 0.41041968266724 2747 3928593
SGTC_1673 st016611 27.3 µM -0.226939935046287 0.387900838101359 no 2071 0.410235224197902 3013 5226799
SGTC_1979 st071809 45.3 µM -0.227373562040231 0.38774654386966 no 2072 0.410066638187212 2958 4976333
SGTC_2206 7254556 146.969 µM -0.227647883988328 0.387648943105393 no 2073 0.409959995560307 2854 4398905
SGTC_2397 5161689 200 µM -0.228017895631458 0.387517308235082 no 2074 0.409816164125597 3016 2259942
SGTC_46 0329-0187a 2.197 µM -0.230149591170385 0.386759191205008 no 2075 0.408987765412239 2901 46494817
SGTC_1039 k821-0043 94 µM -0.230245806031645 0.386724983480082 no 2076 0.408950384888808 2977 15992768
SGTC_188 3229-0966 278.469 µM -0.231026571846399 0.386447426683946 no 2077 0.408647079503962 2855 5722370
SGTC_893 0958-0369 48.9 µM -0.231497520397583 0.386280035838576 no 2078 0.40846415578202 2966 6819948
SGTC_1509 1326-1131 80 µM -0.231836877578799 0.386159430078906 no 2079 0.408332356549193 2814 768313
SGTC_2640 pentamidine 10.38 µM -0.23210657326365 0.386063589493073 no 2080 0.408227619778844 2925 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1392 3455-1037 33.9 µM -0.232542702807792 0.385908618743584 no 2081 0.408058262017335 2965 981132
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.233581792968212 0.385539470239838 no 2082 0.407654831940114 2821 97141
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.234418752560006 0.38524220625763 no 2083 0.407329950873239 2815 368090
SGTC_1583 clindamycin 39.6 µM -0.236040596546195 0.38466636594117 no 2084 0.406700584279198 2809 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1618 st003135 44.5 µM -0.236956062281616 0.384341439453113 no 2085 0.406345438397239 2752 1270615
SGTC_3007 9078383 71.4286 µM -0.237645165612888 0.384096909418214 no 2086 0.406078158372657 2861 6496995
SGTC_2929 9013348 24.6 µM -0.238293244317391 0.383866979164029 no 2087 0.405826830355914 2923 2995952
SGTC_1442 4112-3290 3 µM -0.240952482319697 0.382923943430654 no 2088 0.404795972580621 2833 704353
SGTC_3209 9113616 49.47 µM -0.241286626504002 0.382805496049953 no 2089 0.404666487621059 3024 16649353
SGTC_103 0844-0104 51.839 µM -0.242116281684826 0.382511447415379 no 2090 0.404345031255506 2942 5375804
SGTC_398 bronopol 33.3 µM -0.242344295939042 0.382430645843467 no 2091 0.404256696657538 2802 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_732 3970-1727 52.7 µM -0.24348243540875 0.382027399163772 no 2092 0.403815845137969 2949 1275699
SGTC_3001 9076041 71.4286 µM -0.244693534504373 0.381598443157179 no 2093 0.403346867303107 2831 16004211
SGTC_65 0798-0905 34.986 µM -0.246339340948683 0.381015752384441 no 2094 0.402709779182496 3240 3602145
SGTC_229 benomyl 22.8748 µM -0.246633435743771 0.380911657738164 no 2095 0.402595962871564 2914 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2677 mitomycin C 100 µM -0.248613380149088 0.380211082478706 no 2096 0.401829928773985 2866 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_786 4544-0069 423 µM -0.249211223315295 0.379999621255344 no 2097 0.401598699154273 2960 748821 YLR208W SEC13
SGTC_914 3820-6779 408 µM -0.250828493555896 0.379427761623937 no 2098 0.400973355484587 2809 2893481
SGTC_2860 9025725 38.96 µM -0.251310405480798 0.379257410626041 no 2099 0.400787065429982 2815 40546248
SGTC_2809 7964133 12.99 µM -0.251402463709489 0.37922487163781 no 2100 0.400751481549664 2892 1253665
SGTC_2365 9042475 200 µM -0.251935538716871 0.379036467273053 no 2101 0.400545444716684 2964 6464479
SGTC_2659 sanguinarine 24.21 µM -0.252930621838227 0.378684852580212 no 2102 0.400160912924167 2846 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2318 6029776 164 µM -0.253523760317788 0.378475313600399 no 2103 0.399931751344371 3040 818325
SGTC_1896 st058441 89 µM -0.255336868632549 0.377835015687313 no 2104 0.399231463190599 2881 688759
SGTC_2446 5162541 200 µM -0.256149802638353 0.377548037449063 no 2105 0.398917583724346 2824 1549321
SGTC_1507 4075-3230 155 µM -0.257526130741398 0.377062326565353 no 2106 0.398386322972099 2820 659771
SGTC_456 gingerol 170 µM -0.257725864269633 0.376991856061488 no 2107 0.398309241726187 3038 442793 A herb.
SGTC_2480 5767542 37.17 µM -0.258073688440399 0.376869145612803 no 2108 0.398175018751073 2899 2867358
SGTC_3162 9099653 49.47 µM -0.259376851092651 0.376409507699531 no 2109 0.39767224442347 2926 25237511
SGTC_1496 4469-0713 57.4 µM -0.260842171214398 0.375892884568602 no 2110 0.397107110963717 2992 746691
SGTC_276 colchicine 750 µM -0.260850288850975 0.375890023178509 no 2111 0.397103980816183 2982 2833 A microtubule depolymerizer.
SGTC_2396 5342950 42.78 µM -0.262615765277181 0.375267871829815 no 2112 0.396423373766607 2963 1886677
SGTC_2946 9065502 71.43 µM -0.263862869289449 0.374828589530904 no 2113 0.395942793967579 2892 16489101
SGTC_2394 5221648 200 µM -0.264206767116519 0.374707482837673 no 2114 0.395810298442943 2998 788586
SGTC_1939 st074455 53.6 µM -0.264247831348125 0.374693022527109 no 2115 0.395794478190819 3103 1644229
SGTC_1198 1612-1005 86.7 µM -0.264664035569568 0.374546470804937 no 2116 0.395634142602381 3068 6998509
SGTC_2976 9009005 19.48 µM -0.266190147297597 0.374009259255216 no 2117 0.39504638534705 3100 2993148
SGTC_2428 5615643 7.78 µM -0.26620096906115 0.374005450723266 no 2118 0.395042218370689 3000 2253075
SGTC_415 dibenzyl ketone 100 µM -0.26658258636708 0.373871154999255 no 2119 0.394895282320256 2956 7593
SGTC_1972 st070201 17.4 µM -0.267641216944287 0.373498690344023 no 2120 0.394487750717273 3019 2829099
SGTC_410 α-linolenic acid 100 µM -0.269103095123612 0.372984542823824 no 2121 0.3939251743498 2993 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1394 3474-0001 65.7 µM -0.271442238851591 0.372162328774636 no 2122 0.393025459561353 2927 5017666 YIL048W NEO1
SGTC_561 1550-0330 72.9 µM -0.272763383997919 0.371698200566554 no 2123 0.392517553961095 2894 6812934
SGTC_2838 9002687 71.43 µM -0.273474230242213 0.37144855203986 no 2124 0.392244349444548 2857 6457060
SGTC_364 0083-0097 67.7 µM -0.273749270196122 0.371351972769994 no 2125 0.392138655654227 3028 5207356
SGTC_1978 st071761 42 µM -0.273841924303229 0.371319439444081 no 2126 0.392103051841438 2913 5147680
SGTC_1304 1165-0502 251 µM -0.274792045597302 0.370985879631511 no 2127 0.391738004815922 2908 767425
SGTC_290 2043-6722 48.1 µM -0.275399921923107 0.370772522843075 no 2128 0.391504502031398 2977 773758 YLR208W SEC13
SGTC_2308 7584454 197.62 µM -0.276453497728358 0.370402825394281 no 2129 0.391099885883079 3058 893577
SGTC_2779 methotrexate 400 µM -0.276552327306789 0.370368152444958 no 2130 0.391061937326327 2981 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1464 k208-0027 110 µM -0.278368532440601 0.369731150537768 no 2131 0.390364736355025 3089 X1464
SGTC_1716 st033144 30.6155 µM -0.278588107250389 0.369654162724109 no 2132 0.390280470278429 3058 674617
SGTC_112 phenothiazine 287.218 µM -0.279053905983513 0.36949086062732 no 2133 0.390101728082899 3033 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1147 3809-1045 12.3 µM -0.279523250473713 0.36932633925159 no 2134 0.38992164876247 2919 325925
SGTC_1916 st067606 49.2 µM -0.279633490489255 0.369287699806292 no 2135 0.389879355009892 2984 19590279
SGTC_1363 1636-0063 10.4 µM -0.281395365358189 0.368670336993911 no 2136 0.389203586238772 2915 6072185
SGTC_2179 6298986 200 µM -0.28196178551942 0.368471934660792 no 2137 0.388986406308507 3044 738374
SGTC_265 mycophenolic acid 32.932 µM -0.282507747922226 0.368280731334991 no 2138 0.388777103230061 3154 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1726 st035556 14.5795 µM -0.282662650083922 0.368226488467073 no 2139 0.38871772498163 3108 5919439
SGTC_1694 st024011 44.9 µM -0.284146144526261 0.367707138946652 no 2140 0.38814919272603 2957 2787533
SGTC_843 0310-0051 143 µM -0.285832928540934 0.367116914552224 no 2141 0.38750304323646 2955 2065037
SGTC_3314 9135860 59.4275 µM -0.285865832827208 0.36710540409528 no 2142 0.387490441816993 3062 25252478
SGTC_3107 9121808 49.47 µM -0.286674180553771 0.366822668388849 no 2143 0.387180904547262 2879 662681
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.286910206873992 0.366740127103495 no 2144 0.387090537479294 2992 6708739 YPR165W RHO1
SGTC_2233 sulbentine 40.3845 µM -0.2872126473763 0.366634368974612 no 2145 0.386974751451084 2943 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2772 vinpocetine 57.06 µM -0.287535690006486 0.366521417826207 no 2146 0.386851089232755 3113 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1416 3966-0321 25.3 µM -0.287745965474439 0.366447901679772 no 2147 0.386770600978372 2962 582530 YLR208W SEC13
SGTC_3042 9091578 49.47 µM -0.287921887559084 0.366386399868689 no 2148 0.386703266091749 2946 25236497
SGTC_1120 ficusin 1.78878 µM -0.288103127911132 0.366323042396517 no 2149 0.386633899183635 3061 6199 A DNA cross-linker.
SGTC_2537 larixol 68.93 µM -0.28886944729074 0.36605519500019 no 2150 0.386340642492982 2896 6708759
SGTC_2928 9011484 9.79 µM -0.2926581509866 0.364731911444233 no 2151 0.384891730313754 3042 2994751
SGTC_2594 a-mangostin 100 µM -0.292953309515819 0.364628888585262 no 2152 0.38477892014711 3095 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_306 1672-3436 11.6 µM -0.293843823218459 0.364318120759578 no 2153 0.384438623214591 3026 6797378
SGTC_1242 0402-0103 60.1 µM -0.293845780957554 0.364317437653971 no 2154 0.384437875190903 2893 432868
SGTC_2581 avocatin a 64 µM -0.294923053315588 0.363941614997376 no 2155 0.384026330400394 2973 6710728 A skin care supplement.
SGTC_531 3788-1495 174 µM -0.295661741424223 0.363683988137511 no 2156 0.383744208730114 2874 2896655
SGTC_1040 k898-0338 155 µM -0.295963384390786 0.363578804034653 no 2157 0.383629022176976 3133 20969351
SGTC_2316 5844804 197.44 µM -0.297016684864374 0.363211594655288 no 2158 0.383226885478901 3055 776813
SGTC_1436 4092-1007 8.32 µM -0.29780834168703 0.362935684129565 no 2159 0.382924723769805 2951 2881121
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.298121719049512 0.362826484588673 no 2160 0.382805132723064 2936 5106787 A p450 inhibitor.
SGTC_3096 9117468 49.47 µM -0.301112000569279 0.361785052637928 no 2161 0.38166454516315 3066 41316311
SGTC_639 0833-0042 114 µM -0.303210797760233 0.361054710246238 no 2162 0.380864610352351 2972 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.303398119580894 0.360989550306112 no 2163 0.380793239270449 3185 6710655
SGTC_888 0916-0002 6.97 µM -0.305107532202524 0.360395117307061 no 2164 0.380142127342576 3113 2802138 YIL048W NEO1
SGTC_1045 1348-1485 165 µM -0.306963293464136 0.359750174705037 no 2165 0.379435655904283 2930 6810614
SGTC_1332 1480-0653 17.5 µM -0.307106757642727 0.359700332433694 no 2166 0.379381057121451 3087 5749438
SGTC_3252 9135871 49.47 µM -0.307306117019489 0.359631075035429 no 2167 0.379305190055456 3101 17682838
SGTC_2760 etidronate 98.04 µM -0.30734666103393 0.359616990618836 no 2168 0.379289761425486 2972 3305 A chelator and antioxidant.
SGTC_2228 7354201 200 µM -0.308286122947829 0.359290688284968 no 2169 0.378932312227945 2977 753451
SGTC_3346 9158254 43.5805 µM -0.310535499343073 0.358509832015734 no 2170 0.378076884123785 3039 17639500
SGTC_2732 terfenadine 20 µM -0.310897426254906 0.358384246590796 no 2171 0.37793930057059 2940 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_779 1360-0071 233 µM -0.31266984233439 0.357769455334236 no 2172 0.377265754941503 3153 7566
SGTC_2556 citropten 84.59 µM -0.312833856280594 0.357712583055874 no 2173 0.37720344592963 2981 2775 A potential DNA crosslinker.
SGTC_2313 7726885 200 µM -0.313507282024789 0.357479103985704 no 2174 0.37694764454982 3046 726423
SGTC_1282 0886-0010 32.4 µM -0.315044591077632 0.356946313501928 no 2175 0.376363898819577 3137 2836211 YNL267W PIK1
SGTC_197 4544-0043 41.561 µM -0.315357753930356 0.356837813734607 no 2176 0.376245019491955 2947 896523
SGTC_1017 4239-0030 168 µM -0.315387549586876 0.356827491204722 no 2177 0.376233709414476 2970 1149593
SGTC_1180 1193-0155 285 µM -0.316532258015595 0.356430993151244 no 2178 0.375799272247892 3103 2921347
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.317033723221522 0.356257347123888 no 2179 0.375609006845761 2952 688803
SGTC_2204 7233102 200 µM -0.317174898452862 0.356208466717781 no 2180 0.375555447741948 2976 2172480
SGTC_98 0074-0023 107.663 µM -0.317417283677739 0.356124548950593 no 2181 0.375463497152758 3039 3563821
SGTC_2413 inermin 26.06 µM -0.317503201478209 0.356094804462015 no 2182 0.37543090531132 3242 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2801 7907800 81.82 µM -0.318377003818991 0.355792346445951 no 2183 0.375099489876292 3057 6620925
SGTC_2323 6148992 148.28 µM -0.320369788034523 0.355102903712714 no 2184 0.374344012619032 2990 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_272 doxorubicin 8.13 µM -0.321253182258805 0.354797427706086 no 2185 0.374009266298035 2958 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1309 pyrazolanthrone 13.4 µM -0.322647049984479 0.354315620839045 no 2186 0.37348127851033 3067 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_984 1492-0255 2.91 µM -0.322932874446191 0.354216851005586 no 2187 0.373373039413895 3080 1585198
SGTC_2693 st077581 40.7 µM -0.323219786209814 0.35411771530477 no 2188 0.373264398613544 3106 25238761
SGTC_3343 9148379 18.9835 µM -0.32573703440589 0.353248363178486 no 2189 0.37231166083762 3135 1955036
SGTC_3212 9128307 49.47 µM -0.32655720224167 0.352965276609592 no 2190 0.372001408962661 2910 27243542
SGTC_2935 9038016 29.96 µM -0.329314676546869 0.352014112840664 no 2191 0.37095892598328 3153 6463195
SGTC_2388 9080168 200 µM -0.331009522203219 0.351429951106286 no 2192 0.370318646475647 2973 15943073
SGTC_2266 7929956 200 µM -0.332611129360424 0.350878248123404 no 2193 0.369713920632883 2942 2967153
SGTC_2293 7624732 200 µM -0.333984967895888 0.350405254556052 no 2194 0.369195450950627 2948 894453
SGTC_355 1311-2252 105 µM -0.334553687348966 0.350209520151195 no 2195 0.36898089281653 3014 5338538
SGTC_532 1548-0774 215 µM -0.334807811416459 0.35012207191757 no 2196 0.36888503380665 3216 5932993
SGTC_1052 3253-3998 198 µM -0.335275964335404 0.349960993675264 no 2197 0.368708461596071 2942 5450317
SGTC_574 1315-0397 40 µM -0.336111228785413 0.349673669753931 no 2198 0.368393495586486 2994 6794277
SGTC_3331 9141060 1.957 µM -0.336179547994753 0.349650172328893 no 2199 0.368367737320569 3008 4906567 YPR165W RHO1
SGTC_2854 9024559 71.43 µM -0.337197113936713 0.349300263146742 no 2200 0.367984156387904 3078 3163529
SGTC_452 diindolylmethane 8 µM -0.338398314232947 0.348887372644633 no 2201 0.367531522163153 3116 3071 Inhibits expression of several cancer promoting factors.
SGTC_2190 6049624 200 µM -0.339748870266727 0.348423357478676 no 2202 0.367022827677058 3091 2265554
SGTC_2763 lisinopril 49.32 µM -0.339895982338116 0.348372827362136 no 2203 0.366967431171677 3023 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1208 2323-2347 50.3 µM -0.340468144822019 0.348176326342305 no 2204 0.366752004075748 3160 5412760
SGTC_1818 st052136 56.3 µM -0.341030132569718 0.347983359360495 no 2205 0.366540448757602 3095 674169
SGTC_2759 disulfiram 3.38 µM -0.342827073658583 0.347366616841503 no 2206 0.36586427852591 2983 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2386 9075165 157.42 µM -0.343780675881343 0.347039487333254 no 2207 0.365505616940322 2998 16452277
SGTC_2229 7354935 190 µM -0.344056598079967 0.346944854550025 no 2208 0.365401861106566 3081 318112
SGTC_602 3130-1533 38.1 µM -0.3453931239538 0.346486602694969 no 2209 0.364899422889583 3123 720941
SGTC_2026 5148700 152 µM -0.346462980025578 0.346119945157761 no 2210 0.364497400524227 2989 79838
SGTC_23 0213-0011 39.996 µM -0.346858222588027 0.345984525392611 no 2211 0.364348916951108 3181 627608
SGTC_1946 st076057 65.1 µM -0.346866573858959 0.345981664255433 no 2212 0.364345779789515 2980 953009
SGTC_1091 telmisartan 47.6 µM -0.348599531602863 0.345388145091835 no 2213 0.363694989714346 3123 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3128 9127691 49.47 µM -0.348711080181566 0.345349953919188 no 2214 0.363653112520269 3129 41316314
SGTC_1915 st067105 30.6 µM -0.349106381137708 0.345214626397271 no 2215 0.363504723075845 3028 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1236 0330-0013 258 µM -0.349162274006347 0.345195493601859 no 2216 0.363483743468737 3036 4617066
SGTC_2090 5301565 104.445 µM -0.351009088479615 0.344563529772231 no 2217 0.362790765035705 3023 2056344
SGTC_457 grayanotoxin iii 135 µM -0.352307699040904 0.344119416059152 no 2218 0.362303757417966 3109 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1948 st076329 66.6 µM -0.352781582447405 0.343957405474707 no 2219 0.362126096121222 2947 24208413
SGTC_3311 9131146 2.8755 µM -0.352781906693147 0.343957294631837 no 2220 0.362125974570009 3059 4900406 YPR165W RHO1
SGTC_1561 5-methoxyflavone 52.9 µM -0.353009291334664 0.343879566871487 no 2221 0.362040737464258 3056 94525
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.353100393604602 0.343848426885732 no 2222 0.362006588907388 3012 442882
SGTC_3192 9110362 49.47 µM -0.353267961203297 0.343791152784477 no 2223 0.361943781138243 3027 16649480
SGTC_1590 st077108 57.8 µM -0.353279188537944 0.343787315443391 no 2224 0.361939573036069 3128 5489485
SGTC_778 3456-2434 196 µM -0.353653254320663 0.34365947435545 no 2225 0.361799379488792 3149 5539063
SGTC_199 4063-0024 41.6 µM -0.353975389021069 0.343549395611569 no 2226 0.361678663696564 3141 306215
SGTC_2112 5488546 200 µM -0.354538322115751 0.343357063935421 no 2227 0.361467744885168 3001 600757
SGTC_1955 wogonin 32.4 µM -0.354975696603445 0.343207658597786 no 2228 0.361303899211373 3235 5281703 A flavanone.
SGTC_2866 9034245 58.44 µM -0.356224738955871 0.342781125811865 no 2229 0.360836133258004 3083 6462273
SGTC_2798 7813637 45.45 µM -0.35661419141905 0.342648173472563 no 2230 0.360690325962539 3151 956368
SGTC_882 0843-0131 351 µM -0.356806837087179 0.342582414775095 no 2231 0.360618208742226 3159 5425421
SGTC_920 mycophenolic acid 780.421 nM -0.357706455899058 0.34227539728603 no 2232 0.360281500632127 3057 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3034 9090421 49.47 µM -0.360214614236986 0.341419976183152 no 2233 0.359343323343241 3086 17173761
SGTC_1024 4507-0395 26 µM -0.363618890825496 0.340260231843956 no 2234 0.358071309127613 3207 4201836
SGTC_179 1273-0063 6.77 µM -0.363741707827675 0.34021841958081 no 2235 0.358025447661486 3032 3108139
SGTC_1964 st076914 61 µM -0.364120237407541 0.340089563965843 no 2236 0.357884112683207 3051 24208661
SGTC_1672 st016598 6.51 µM -0.364456337240617 0.339975167553345 no 2237 0.357758636404972 3068 4665860 YNL267W PIK1
SGTC_296 1222-0039 74.9 µM -0.366579919188638 0.339252716876715 no 2238 0.356966194582445 3077 5984176
SGTC_511 blebbistatin 171 µM -0.367589307325116 0.338909526071573 no 2239 0.356589744485353 3202 3476986 A myosin inhibitor.
SGTC_1258 0671-0043 57.1 µM -0.368033988945976 0.338758377227203 no 2240 0.356423945301073 3107 4298767
SGTC_2377 9073351 62.6 µM -0.368060591819971 0.338749335639712 no 2241 0.35641402730078 3034 7337946 YHR072W ERG7
SGTC_917 harmaline 728.087 nM -0.368246022127508 0.338686315543478 no 2242 0.356344898451251 3139 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3150 9097574 49.47 µM -0.36836631342625 0.338645435918546 no 2243 0.356300056099682 3220 17217476
SGTC_1009 4106-0057 9.87 µM -0.369751990978714 0.338174666391962 no 2244 0.355783644781951 3212 2928005
SGTC_337 1315-0038 354 µM -0.369958896209147 0.338104394176597 no 2245 0.355706558464095 3068 1626437
SGTC_97 0535-0701 19.132 µM -0.370575367868329 0.337895052397944 no 2246 0.355476915693624 3077 2832013 YGL099W LSG1
SGTC_2217 6934799 96.0675 µM -0.370634788710744 0.33787487688404 no 2247 0.355454783518186 3143 675606
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.372683429346133 0.337179574876655 no 2248 0.354692035430159 3060 390807
SGTC_934 2950-0684 338 µM -0.374024113506952 0.336724851716077 no 2249 0.354193188042087 3248 1121253
SGTC_378 3970-0959 8.33 µM -0.374380121258363 0.336604143751109 no 2250 0.35406076517322 3175 6615653
SGTC_1661 st013063 9.66 µM -0.374695400343347 0.33649725929988 no 2251 0.353943506728639 3072 721395
SGTC_1292 0kpi-0043 232 µM -0.376246652856722 0.335971553416314 no 2252 0.35336676757464 3108 3333905
SGTC_105 0111-0055 734.78 µM -0.376385441125501 0.335924534904405 no 2253 0.35331518395836 3145 5179370
SGTC_2663 amphotericin b 100 µM -0.376855664148752 0.335765252441486 no 2254 0.353140435591015 3120 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2634 4'-methoxyflavone 100 µM -0.377586514030029 0.335517744291234 no 2255 0.352868892280271 3127 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1581 himbacine 57.9 µM -0.37872765718957 0.335131429766685 no 2256 0.352445056597251 3063 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1287 0971-0001 34.6 µM -0.379188480882422 0.334975475166844 no 2257 0.352273952457588 3109 4665869
SGTC_3085 9117376 49.47 µM -0.379847429146341 0.334752519545007 no 2258 0.352029336481399 3162 16480349
SGTC_2951 9072950 58.06 µM -0.382506216741822 0.333853509126825 no 2259 0.35104295928205 3125 16488155
SGTC_1070 indatraline 8.81 µM -0.3827731248195 0.333763312587217 no 2260 0.350943994977383 3094 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_943 3253-1379 105 µM -0.383605615861527 0.333482049695439 no 2261 0.350635388522352 3253 668464
SGTC_1758 st042942 75.2445 µM -0.384211515148062 0.333277401235312 no 2262 0.350410842128752 3149 669317
SGTC_1617 st002906 78 µM -0.387058313312454 0.332316532238426 no 2263 0.349356519031059 3066 5150859
SGTC_255 tunicamycin 200.472 nM -0.387454432188864 0.33218291886101 no 2264 0.349209906674822 3142 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1422 4031-0024 15.5 µM -0.387904509481631 0.332031130858488 no 2265 0.349043350422643 3146 782427
SGTC_2110 5483698 200 µM -0.387909029403524 0.332029606660228 no 2266 0.349041677921245 3106 2848765 YHR062C RPP1
SGTC_1425 4048-4433 7.33 µM -0.388847350314028 0.331713248327623 no 2267 0.348694535670992 3174 23734946
SGTC_1791 st048313 56.1 µM -0.390077026807133 0.331298840059428 no 2268 0.348239794948786 3188 1204976
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.390104840913535 0.331289468927083 no 2269 0.348229511668378 3158 229346 A bile salt which induces apoptosis.
SGTC_1555 citronellol 128 µM -0.39035262124076 0.33120599141026 no 2270 0.348137908596247 3170 8842 A terpine precursor.
SGTC_953 1188-0045 9.7 µM -0.390511806571773 0.33115236608878 no 2271 0.348079063298018 3189 6144426
SGTC_2584 androsterone 48.74 µM -0.390794838003604 0.331057028849045 no 2272 0.347974445424405 3207 2754130 A steroid.
SGTC_951 1171-0579 82.7 µM -0.391173096885654 0.330929631982115 no 2273 0.347834646370164 3076 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_988 1497-1057 103 µM -0.393591967319865 0.3301154244205 no 2274 0.346941156334731 3213 3533044
SGTC_2561 acetosyringone 100 µM -0.39438966531448 0.329847090158508 no 2275 0.346646686333155 3055 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_440 fluspirilene 35.1 µM -0.395432809315196 0.329496323450142 no 2276 0.346261749790941 3300 3396 An atypical antipsychotic.
SGTC_2103 5378138 10 µM -0.395718469427291 0.329400293769642 no 2277 0.346156364391052 3164 244142
SGTC_3269 9137823 49.47 µM -0.398306235151627 0.328530883993929 no 2278 0.345202232458932 3078 17682936
SGTC_1973 st070275 50.2 µM -0.398410471692611 0.32849588312076 no 2279 0.345163820089566 3168 17118334
SGTC_2144 5628481 200 µM -0.399098645111301 0.328264843864964 no 2280 0.344910260282758 3127 2818399
SGTC_1563 conessine 56.1 µM -0.39913172690029 0.328253739027607 no 2281 0.344898072939806 3195 441082 An anti-amoebic, histamine inhibitor.
SGTC_451 chloral hydrate 100 µM -0.400689569402628 0.327730977156122 no 2282 0.344324345608852 3204 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1604 st002052 72.4 µM -0.400836976445 0.327681529551043 no 2283 0.344270076583891 3236 6254834 YHR062C RPP1
SGTC_933 2914-0560 114 µM -0.401631547641562 0.327415043176093 no 2284 0.343977604397774 3264 463887
SGTC_776 4476-4378 112 µM -0.403273009781049 0.32686480176595 no 2285 0.343373697449761 3191 2892008
SGTC_2373 9071805 200 µM -0.406026455314194 0.325942653100354 no 2286 0.342361581086037 3273 10149009
SGTC_2698 st077697 67.5 µM -0.406225276501882 0.3258761075665 no 2287 0.342288541744409 3137 3154499
SGTC_2522 biochanin a 4.94 µM -0.406626632877616 0.325741790322639 no 2288 0.34214111665431 3244 5280373 A possible chelator.
SGTC_1534 6-azauridine 81.6 µM -0.408459317159471 0.325128754960353 no 2289 0.341468246279127 3132 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_354 2783-3500 4.88 µM -0.410179253373315 0.32455386418944 no 2290 0.340837229338349 3143 6740761
SGTC_474 dl-dihydrosphingosine 5 µM -0.412035678006442 0.323933820822228 no 2291 0.340156636424851 3267 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_874 0599-0792 117 µM -0.413099121702756 0.323578851850044 no 2292 0.339766996442992 3286 765305
SGTC_3035 9091303 49.47 µM -0.41323456454242 0.323533653630901 no 2293 0.339717383202185 3183 25237002
SGTC_3191 9110352 49.47 µM -0.413961024209507 0.323291273422258 no 2294 0.339451325597171 3188 17122424
SGTC_577 r071-0003 38.6 µM -0.415528311256053 0.322768610199479 no 2295 0.338877597136045 3140 4568517 YMR134W ERG29
SGTC_2994 9053520 71.4286 µM -0.41759491817453 0.322079967379029 no 2296 0.338121656460327 3242 4647384
SGTC_3187 9109394 49.47 µM -0.418341032754464 0.321831494012853 no 2297 0.337848896534912 3167 17098090
SGTC_1166 k206-0078 225 µM -0.419539464351414 0.321432555393964 no 2298 0.337410959593826 3125 5404595
SGTC_485 niflumic acid 177 µM -0.420707645761544 0.321043884717821 no 2299 0.336984288694951 3251 4488 A COX2 inhibitor.
SGTC_2576 guaiol 23.12 µM -0.422862200629842 0.320327547775817 no 2300 0.336197901354473 3191 227829
SGTC_2583 asiatic acid 100 µM -0.424722583659154 0.319709553838702 no 2301 0.335519459330746 3319 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1986 st071812 45 µM -0.424881568593897 0.319656764382351 no 2302 0.335461505741102 3223 11838594
SGTC_2775 cyproheptadine 69.59 µM -0.425442559761486 0.319470521723371 no 2303 0.335257043109753 3256 2913 A selective serotonin reuptake inhibitor.
SGTC_233 rapamycin 362 pM -0.426137465703638 0.319239884021125 no 2304 0.335003840655232 3229 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1779 st039427 55 µM -0.426411436869812 0.31914897283096 no 2305 0.334904034547792 3347 1124498
SGTC_512 prima-1 270 µM -0.428310104549182 0.318519241601709 no 2306 0.334212681630416 3298 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2870 9038528 12.99 µM -0.428394819032863 0.318491156539513 no 2307 0.334181848026311 3261 6463316
SGTC_2132 5317594 122.667 µM -0.430043445346897 0.317944801699305 no 2308 0.333582019079522 3119 794577
SGTC_2354 9060492 162 µM -0.430945356327804 0.317646075863969 no 2309 0.333254051569388 3293 6471895
SGTC_3206 9114350 49.47 µM -0.434144051679778 0.316587580054048 no 2310 0.332091919064211 3243 17087243
SGTC_2754 granisetron 64.02 µM -0.435200083138695 0.31623845254318 no 2311 0.331708601122249 3311 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_381 3461-2219 42.7 µM -0.435814976654768 0.316035242115679 no 2312 0.331485488392579 3251 2883159
SGTC_382 3229-0966 23.2 µM -0.437055305089873 0.315625506673087 no 2313 0.331035619995364 3316 5722370
SGTC_3302 9125395 16.351 µM -0.437608236689119 0.315442921836559 no 2314 0.330835149672306 3180 17599668
SGTC_2627 acetyl isogambogic acid 100 µM -0.439222119398092 0.314910255643859 no 2315 0.33025029954596 3261 6857789 A caspase activator and apoptosis inducer.
SGTC_3129 9127257 49.47 µM -0.440205650283359 0.314585827329222 no 2316 0.329894083889227 3155 837894
SGTC_2587 piperic acid 92.2 µM -0.441193782027261 0.31426002547185 no 2317 0.329536357167779 3192 5370536
SGTC_221 trifluoperazine 10.304 µM -0.443124412089755 0.313623885368618 no 2318 0.328837874270011 3245 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_497 capsazepine 133 µM -0.445605827600392 0.312807075629025 no 2319 0.327941000141028 3202 2733484 A calcium channel blocker.
SGTC_871 0574-0004 149 µM -0.446997214716557 0.312349473005854 no 2320 0.327438535469457 3161 9551173
SGTC_1295 1013-0063 9.78 µM -0.447438822270864 0.312204296528227 no 2321 0.327279125216935 3317 6826038
SGTC_110 0850-0284 111.64 µM -0.447783568415863 0.312090983061578 no 2322 0.327154701612778 3079 3906265
SGTC_1375 2910-0797 186 µM -0.450901004388715 0.311067131612052 no 2323 0.326030449800305 3209 742508
SGTC_1057 3448-5381 134 µM -0.451499855871969 0.310870619344657 no 2324 0.325814664449559 3283 5497911
SGTC_1181 1222-0449 220 µM -0.452670045125856 0.310486779077724 no 2325 0.325393176245959 3349 658318
SGTC_2100 5377183 190 µM -0.455817683229669 0.309455329329723 no 2326 0.324260543531846 3264 2844202
SGTC_1143 3454-2408 5.08 µM -0.458586391153572 0.308549290128609 no 2327 0.323265605555741 3279 X1143
SGTC_24 0417-1663 219 µM -0.459622786401781 0.308210436674441 no 2328 0.322893500291166 3290 4329390
SGTC_1276 0871-0068 94.2 µM -0.461587987486824 0.30756835532346 no 2329 0.322188405301254 3257 3414906
SGTC_3025 9087895 49.47 µM -0.463338459035114 0.306996927522155 no 2330 0.321560891454828 3330 17173641
SGTC_1171 0368-0077 21.4 µM -0.464171390923788 0.306725187808539 no 2331 0.321262478285226 3190 3239779
SGTC_2750 bromebric acid 70.15 µM -0.465059196297956 0.306435662815912 no 2332 0.320944532684499 3339 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2868 9035608 32.47 µM -0.465773753765311 0.306202723962277 no 2333 0.320688726868136 3213 6462614
SGTC_309 k408-0051 1.48 µM -0.467589374853144 0.305611201469668 no 2334 0.320039132315275 3295 3640463
SGTC_3094 9117742 49.47 µM -0.468079967150592 0.30545145528741 no 2335 0.319863702289354 3224 17149698
SGTC_1557 sumaresinolic acid 42.3 µM -0.469298349764358 0.305054886982477 no 2336 0.319428197328822 3222 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1134 3477-0009 42.5 µM -0.469308107724555 0.305051711811474 no 2337 0.319424710397442 3416 3973534
SGTC_1857 st056007 79.3 µM -0.469635382950961 0.304945227276662 no 2338 0.319307770384743 3327 619834
SGTC_2910 7948405 25.97 µM -0.470093001199621 0.304796361126555 no 2339 0.319144287124897 3340 2971328
SGTC_1333 1482-0047 286 µM -0.470385448051541 0.304701243211392 no 2340 0.319039829451806 3340 3811116
SGTC_2282 7944268 200 µM -0.470442459947839 0.304682701712078 no 2341 0.319019467322365 3392 2970414
SGTC_1736 st036774 51 µM -0.470832716999921 0.304555795168646 no 2342 0.3188800994192 3428 1272247
SGTC_1086 cerivastatin 2.18 µM -0.471502533286676 0.304338034417498 no 2343 0.31864095551923 3296 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_200 k038-0079 37.545 µM -0.472056027842485 0.304158142795003 no 2344 0.318443398839676 3219 3436683
SGTC_1027 k015-0025 8.67 µM -0.473179703701827 0.303793081985222 no 2345 0.318042488339863 3223 3598955
SGTC_1652 st011932 78 µM -0.473261173549113 0.303766621591068 no 2346 0.318013429415165 3302 1551076
SGTC_2667 digitoxin 100 µM -0.473269004138275 0.303764078367174 no 2347 0.31801063643469 3299 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_140 0062-0056 502.533 µM -0.473525916922678 0.303680643334189 no 2348 0.31791900764192 3200 3758964
SGTC_83 0170-0301 39.027 µM -0.478435667788252 0.302088121908111 no 2349 0.316170076136882 3310 3089716
SGTC_3074 9116018 49.47 µM -0.478588998584879 0.302038448128397 no 2350 0.316115523170144 3219 17027303
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.479992396781115 0.301583967064791 no 2351 0.31561639971279 3348 5282362
SGTC_3196 9111891 49.47 µM -0.481230444252853 0.301183289311083 no 2352 0.315176362830435 3314 18891510
SGTC_814 3342-0569 96 µM -0.482217831846607 0.300863906333843 no 2353 0.314825605357552 3376 4346283
SGTC_2823 7987624 58.44 µM -0.482274288822392 0.300845649230344 no 2354 0.314805554745233 3445 2239440
SGTC_897 1000-0139 31.4 µM -0.48394473792927 0.300305684319364 no 2355 0.314212544442812 3378 6151020
SGTC_1792 st045773 43.6 µM -0.483965760656413 0.3002988916122 no 2356 0.314205084414402 3247 2919270
SGTC_2097 5376186 200 µM -0.48506502104808 0.299943803571141 no 2357 0.313815111725696 3327 742755
SGTC_735 3076-0345 636 µM -0.485653009271317 0.299753947004682 no 2358 0.31360660283362 3392 2888990
SGTC_2037 5169046 200 µM -0.486881312102093 0.299357513817034 no 2359 0.313171221521725 3348 5718022
SGTC_1836 st055642 81 µM -0.487198685104429 0.299255120751469 no 2360 0.313058768536055 3253 8571
SGTC_2063 5246145 200 µM -0.487554068108924 0.299140483499262 no 2361 0.312932868315819 3361 711240
SGTC_281 1672-3440 14.9 µM -0.487896245295763 0.299030124937119 no 2362 0.312811667083418 3340 6833000
SGTC_844 0330-0132 15.3 µM -0.491303930748211 0.297932092762696 no 2363 0.311605750070945 3385 2828079
SGTC_1909 st060837 51.5 µM -0.491802848680225 0.297771484668288 no 2364 0.311429361260487 3266 678937
SGTC_3142 9086498 49.47 µM -0.49449922335231 0.296904171318356 no 2365 0.310476827356529 3308 25236367
SGTC_1884 5633444 25 µM -0.494650724682961 0.296855473859112 no 2366 0.3104233449007 3374 5724239
SGTC_773 4358-1457 44.6 µM -0.496859296563494 0.296145982414376 no 2367 0.309644138336985 3383 1186886
SGTC_1901 st060216 58.6 µM -0.497578356855303 0.295915156293815 no 2368 0.309390630844422 3260 688792
SGTC_2238 6671620 73.2395 µM -0.498994030291873 0.295460951441488 no 2369 0.308891794805504 3298 729941
SGTC_1049 3226-0134 66 µM -0.499521352821699 0.295291847215352 no 2370 0.30870607396121 3354 5702385
SGTC_715 0868-0130 184 µM -0.50005749121238 0.295119961558199 no 2371 0.308517298354438 3412 2876258
SGTC_158 k038-0087 26.446 µM -0.501330645983461 0.294711973604625 no 2372 0.308069220360001 3238 X158
SGTC_1643 st009866 20.2 µM -0.501501918452074 0.294657108456467 no 2373 0.308008964008015 3350 3156273 YOR207C RET1
SGTC_3077 9117319 49.47 µM -0.502459635533006 0.294350401766172 no 2374 0.307672119474271 3363 17154678
SGTC_1859 st055998 20 µM -0.503298536562231 0.294081866822606 no 2375 0.307377197598308 3427 676301
SGTC_3130 9127414 49.47 µM -0.506954845771085 0.292912794752777 no 2376 0.306093250773674 3360 1494646
SGTC_1489 4065-0444 182 µM -0.507462602963024 0.29275061465874 no 2377 0.30591513487074 3379 2877968
SGTC_2408 sulbentine 18.36 µM -0.507682653808608 0.292680342311947 no 2378 0.305837957590624 3244 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1289 0976-0073 69.1 µM -0.508991974909125 0.292262378012512 no 2379 0.305378924619856 3387 3391136
SGTC_793 0488-0545 106 µM -0.510165845676602 0.291887888673503 no 2380 0.304967638960953 3260 292548
SGTC_2240 6690706 185.951 µM -0.511028251514499 0.291612905659385 no 2381 0.304665637232606 3199 805876
SGTC_3205 9113483 49.47 µM -0.511069738791008 0.2915996802503 no 2382 0.304651112357283 3416 17018033
SGTC_1257 0669-0121 16 µM -0.511433176110416 0.291483834825851 no 2383 0.304523884544346 3338 4307855
SGTC_2211 7117706 200 µM -0.511878439623172 0.29134193661881 no 2384 0.304368044223573 3365 822771
SGTC_2653 dihydrofissinolide 100 µM -0.512294124055615 0.291209493883198 no 2385 0.304222588508286 3388 6857746
SGTC_245 methotrexate 289.6 µM -0.512461206037688 0.291156267203475 no 2386 0.304164132140117 3354 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1572 epiandrosterone 68.9 µM -0.512694609946944 0.291081920202986 no 2387 0.304082480339004 3340 441302 A steroid.
SGTC_708 3448-5400 146 µM -0.512800504543795 0.291048192134316 no 2388 0.304045438403316 3382 3462195
SGTC_1526 st051518 75 µM -0.513304725924465 0.290887619626316 no 2389 0.303869089332978 3283 673993
SGTC_1246 0422-0085 105 µM -0.51443538862788 0.290527703496985 no 2390 0.303473811294282 3429 264295
SGTC_3113 9123498 49.47 µM -0.516625707369705 0.289831067833931 no 2391 0.302708733283506 3403 8897275
SGTC_1440 4100-1550 40 µM -0.518327957445989 0.28929020519819 no 2392 0.302114734975117 3360 742806
SGTC_2923 7992654 58.14 µM -0.518846093623781 0.289125669962435 no 2393 0.301934035858974 3344 2985126
SGTC_2099 5377090 177.372 µM -0.51942000296711 0.288943475222172 no 2394 0.301733942642318 3376 2243829
SGTC_353 1988-1175 58.3 µM -0.521409228558276 0.288312389035068 no 2395 0.301040862004966 3255 2788357
SGTC_1209 2323-2347 50.3 µM -0.522949178727057 0.287824283249887 no 2396 0.300504810004843 3395 5412760
SGTC_1475 4092-1048 11.7 µM -0.5231300039015 0.287766994145651 no 2397 0.300441893600114 3405 2881759
SGTC_413 propylparaben 100 µM -0.523604930331185 0.287616553424264 no 2398 0.300276675798322 3316 7175 A pharmaceutical preservative.
SGTC_3267 9137951 49.47 µM -0.524629489578515 0.287292134174307 no 2399 0.299920391213641 3289 16643986
SGTC_2714 st079313 56.9 µM -0.524976666522082 0.287182242406327 no 2400 0.299799705844793 3352 2939799
SGTC_2379 9035213 200 µM -0.525276634378294 0.287087309736496 no 2401 0.299695448971693 3423 646551
SGTC_1719 st032227 49.2 µM -0.525520716759755 0.287010074452746 no 2402 0.299610627783012 3315 3125804
SGTC_2458 5808907 16.39 µM -0.52649859832854 0.286700740942641 no 2403 0.299270912818801 3467 2731747
SGTC_2325 6158266 200 µM -0.527537994522451 0.286372121902154 no 2404 0.298910019451719 3364 3623240
SGTC_1930 st074634 34.3 µM -0.529707978189278 0.285686629342383 no 2405 0.298157207763659 3309 684253 YOR116C RPO31
SGTC_3277 9138724 49.47 µM -0.53291940343415 0.284673582850807 no 2406 0.297044686465283 3319 15943418
SGTC_594 1487-1584 10.8 µM -0.533448106803109 0.284506967523559 no 2407 0.296861712013478 3311 5013332
SGTC_2862 9027634 71.43 µM -0.533894558245403 0.28436630931231 no 2408 0.296707243611447 3293 5012562
SGTC_1283 0922-0125 16.4 µM -0.534340384634131 0.284225881199618 no 2409 0.296553028209738 3388 3360884
SGTC_1454 4239-0054 42.6 µM -0.535304831751292 0.283922209423536 no 2410 0.296219542895349 3518 1340767
SGTC_1217 1183-1422 255 µM -0.536405384209025 0.283575872484433 no 2411 0.295839205534925 3429 2849664
SGTC_1372 2752-0194 270 µM -0.537166638490691 0.283336429040139 no 2412 0.295576256749196 3415 823334
SGTC_141 0443-0274 32.331 µM -0.537536296368371 0.283220192547623 no 2413 0.295448610075425 3523 1627241
SGTC_1316 1272-0050 65.9 µM -0.540124760863242 0.282406908418286 no 2414 0.294555497873396 3421 7340392
SGTC_2347 9049783 174.81 µM -0.540556751965426 0.282271288175451 no 2415 0.294406566981436 3448 6467988 YPL169C MEX67
SGTC_625 k213-0058 121 µM -0.54106474156746 0.282111848902257 no 2416 0.294231479751553 3432 3655420
SGTC_1841 st054148 70 µM -0.542331775182371 0.281714362651718 no 2417 0.293794984878754 3389 675442
SGTC_1570 verbenone 133 µM -0.542947780971307 0.281521210568913 no 2418 0.293582878305502 3470 29025 A natural terpanoid with antifungal properties.
SGTC_1620 st003704 16.5 µM -0.542984141997535 0.281509811361489 no 2419 0.293570360489095 3452 2834414
SGTC_2902 5787006 60.46 µM -0.543875094790658 0.281230566626128 no 2420 0.293263714174851 3313 591003
SGTC_766 1391-0721 126 µM -0.545042153346034 0.280864986576584 no 2421 0.29286226311318 3445 1020919 YIL115C NUP159
SGTC_368 fentichlor 4.58 µM -0.545128651307101 0.280837900315036 no 2422 0.292832519237216 3373 7329 A pesticide.
SGTC_3194 9111903 49.47 µM -0.54750777287621 0.280093389718476 no 2423 0.292014965922978 3482 17087251
SGTC_192 3455-0609 60.9 µM -0.550911703472286 0.279029846687295 no 2424 0.290847102105534 3476 3769639
SGTC_1317 1273-0028 910 nM -0.553063466149178 0.27835855268148 no 2425 0.290109976120447 3369 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3020 9089140 49.47 µM -0.554427975972605 0.277933269329979 no 2426 0.289642992216283 3470 17217859
SGTC_898 1000-0849 28.3 µM -0.555033545226491 0.277744630294256 no 2427 0.289435857936201 3426 6751807
SGTC_1379 2144-0755 36.5 µM -0.555231215470318 0.277683068176721 no 2428 0.289368260118979 3515 5392327
SGTC_2406 ethylparaben 405.7 µM -0.55671501759215 0.277221168029554 no 2429 0.288861077352889 3204 8434 A possible steroid mimic.
SGTC_810 3825-7150 143 µM -0.561671696891312 0.275680909023908 no 2430 0.2871698607079 3503 22330411 YGL099W LSG1
SGTC_699 0375-0592 111 µM -0.562383822183152 0.27545996637472 no 2431 0.286927269508734 3491 762578
SGTC_2648 atorvastatin 78.68 µM -0.562726055763711 0.275353816629018 no 2432 0.286810719443895 3488 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2644 guaiazulene 100 µM -0.564737062350433 0.274730474646283 no 2433 0.286126310656418 3459 3515 A coloring agent.
SGTC_1588 farnesol 29.9 µM -0.564834721912338 0.274700221308304 no 2434 0.286093093799444 3477 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2231 micatex 6.853 µM -0.564836580062141 0.274699645699756 no 2435 0.286092461806422 3453 20737 An antifungal of unknown mechanism.
SGTC_2787 5284540 71.43 µM -0.565322069800465 0.274549273447698 no 2436 0.285927360000441 3402 736958
SGTC_321 4534-3890 65.3 µM -0.565766760913417 0.274411573525287 no 2437 0.285776172448599 3450 699746
SGTC_2191 5911152 200 µM -0.565896944140268 0.27437126835409 no 2438 0.285731919521468 3418 2875902
SGTC_2202 7226349 200 µM -0.566926617324621 0.274052581025664 no 2439 0.285382019654825 3388 844334
SGTC_2799 7812892 81.82 µM -0.57141764280711 0.272664735824277 no 2440 0.283858286251062 3501 20205235
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.572017881812273 0.272479510745742 no 2441 0.283654930121532 3454 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3337 9144342 33.5465 µM -0.573088456901243 0.272149301932563 no 2442 0.283292401249458 3458 17682949
SGTC_348 k064-0012 10.7 µM -0.574454926419392 0.271728116455855 no 2443 0.282829996709232 3406 5066323
SGTC_3050 9093513 49.47 µM -0.574654296888401 0.271666691836668 no 2444 0.282762561335564 3491 25236664
SGTC_273 hydroxyurea 18.1 mM -0.574859279429797 0.271603545385978 no 2445 0.282693235780758 3496 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3040 9091894 49.47 µM -0.576912149648273 0.270971546302147 no 2446 0.281999401342262 3418 25236966
SGTC_2709 st078560 56 µM -0.579585744743539 0.270149551636692 no 2447 0.281097004240162 3538 17250903
SGTC_2892 9047358 58.44 µM -0.579637206081419 0.270133742132385 no 2448 0.281079648599905 3413 6466771
SGTC_2287 7945887 168.79 µM -0.582857244378263 0.269145431385585 no 2449 0.279994702546681 3474 1245853
SGTC_3082 9117008 49.47 µM -0.584066590513951 0.268774721820025 no 2450 0.279587755678933 3435 41448529
SGTC_1107 amlodipine 47 µM -0.585185298465279 0.268432024741335 no 2451 0.279211564537737 3433 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_935 2996-0153 430 µM -0.585622946483443 0.268298018558578 no 2452 0.279064462358221 3509 23738523
SGTC_1616 st002734 56.1 µM -0.585679633017738 0.268280663816273 no 2453 0.279045411646868 3421 4026101
SGTC_1594 piperine 70.1 µM -0.586472970938822 0.268037840447456 no 2454 0.278778860007234 3481 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_877 0771-0151 33.1 µM -0.587138072911699 0.26783435259395 no 2455 0.278555489588045 3453 6166523
SGTC_269 exalamide 29 µM -0.587341268979227 0.267772200309098 no 2456 0.278487264823673 3429 3316 A derivative of salicylamide.
SGTC_2670 beta-carotene 100 µM -0.587445072375559 0.267740452409377 no 2457 0.278452415114635 3471 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2769 toremifene 3.73 µM -0.588410329621819 0.267445322764614 no 2458 0.278128452995457 3544 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2200 6600604 21.907 µM -0.589355509458985 0.267156490910881 no 2459 0.277811407554877 3456 2904777
SGTC_1522 st012842 45.6 µM -0.592079456757445 0.266324977877843 no 2460 0.276898691332827 3452 3491067 YOR116C RPO31
SGTC_1225 1216-0074 20.6 µM -0.593675808105709 0.265838284563648 no 2461 0.276364483292764 3452 4241466
SGTC_740 k014-0057 261 µM -0.593691346155726 0.265833549561213 no 2462 0.27635928607609 3469 4012779
SGTC_817 1391-0715 46 µM -0.594049853372786 0.265724311395711 no 2463 0.276239384751455 3441 1353946
SGTC_802 4112-3352 742 µM -0.595722923028952 0.265214823429898 no 2464 0.275680170978921 3545 704594
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.596329436326377 0.265030248838764 no 2465 0.275477584975127 3511 61125 An anti-inflammatory.
SGTC_206 4546-0025 72.014 µM -0.596585373851119 0.264952381319543 no 2466 0.275392119361289 3524 6620745 YIL048W NEO1
SGTC_196 k015-0023 18.111 µM -0.596765746536987 0.264897510952339 no 2467 0.275331895069361 3495 5211998
SGTC_1801 st050089 28.441 µM -0.597426419586985 0.264696579893153 no 2468 0.275111359569944 3513 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2720 fluspirilene 36.88 µM -0.597442352677867 0.264691735105944 no 2469 0.275106042110304 3490 3396 An atypical antipsychotic.
SGTC_3199 9111318 49.47 µM -0.597494972520257 0.264675735270371 no 2470 0.275088481289224 3464 8548020
SGTC_2101 5377231 179.231 µM -0.599129649727342 0.264178932780024 no 2471 0.274543215576861 3512 2844213
SGTC_2025 5147754 141 µM -0.599554156636877 0.26404999660604 no 2472 0.274401703595698 3510 315777 YLR208W SEC13
SGTC_1587 estradiol valerate 56.1 µM -0.60119695170907 0.263551330114055 no 2473 0.273854407275652 3551 13791 A steroid.
SGTC_2020 4017018 200 µM -0.601396332930447 0.263490841142587 no 2474 0.273788020271471 3515 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2299 7976368 114.88 µM -0.602173390798086 0.263255162253449 no 2475 0.273529363037542 3499 2979718
SGTC_967 1306-0166 352 µM -0.602536589179943 0.263145042409618 no 2476 0.273408507625681 3527 4437607
SGTC_3099 9120367 49.47 µM -0.602815668018409 0.263060443162423 no 2477 0.273315661224849 3547 24824940
SGTC_527 4476-4215 268 µM -0.603104958970218 0.262972762915249 no 2478 0.27321943385471 3408 4418754
SGTC_1490 4089-0339 670 nM -0.603879668973632 0.262738032190088 no 2479 0.272961823359784 3507 742542
SGTC_462 ag-879 158 µM -0.606745677662636 0.261870587896165 no 2480 0.272009851786983 3546 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3071 9117417 49.47 µM -0.60696403321822 0.261804559289404 no 2481 0.271937390693163 3441 45595590 YGL055W OLE1
SGTC_576 1073-0113 22.7 µM -0.607748922759887 0.261567286828232 no 2482 0.271677005121212 3673 5439563
SGTC_3003 9075612 71.4286 µM -0.608345224167306 0.261387098458926 no 2483 0.271479266296655 3529 6501993
SGTC_2889 9059656 51.95 µM -0.609383748621778 0.261073432873404 no 2484 0.271135053642164 3545 3949838
SGTC_1227 3909-8010 46.6 µM -0.61076227128371 0.260657376699692 no 2485 0.270678487057605 3497 15982272
SGTC_695 3505-6186 243 µM -0.614393116811971 0.259563175453514 no 2486 0.269477791575834 3542 1819379
SGTC_2023 5144124 124 µM -0.615760788476384 0.25915162610164 no 2487 0.269026205207079 3505 2830192
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.615991254540872 0.259082309233328 no 2488 0.268950145895272 3606 688801
SGTC_2052 5265182 7.135 µM -0.618285432087128 0.258392816604446 no 2489 0.268193601547174 3535 1239884
SGTC_1188 1403-0014 4.57 µM -0.619142893421517 0.258135359267513 no 2490 0.267911114152993 3551 9614867
SGTC_376 3970-0862 59.1 µM -0.619147914048745 0.25813385218919 no 2491 0.26790946056772 3538 3135186
SGTC_554 4483-2211 187 µM -0.620338619980562 0.257776558183699 no 2492 0.267517436904965 3496 747107
SGTC_198 3454-2873 16.191 µM -0.621582398908425 0.257403612904017 no 2493 0.267108248786833 3500 710957
SGTC_600 1495-0418 41.6 µM -0.623603107766984 0.256798304614082 no 2494 0.266444134573133 3549 5377768
SGTC_1307 1187-1599 12.2 µM -0.623858515109193 0.256721849494654 no 2495 0.266360253408233 3486 1538471
SGTC_226 1,3-diallylurea 8.28947 mM -0.624622367759013 0.256493264138608 no 2496 0.266109467833163 3516 74537 YKL182W FAS1
SGTC_2338 7999974 200 µM -0.625148093901575 0.25633600052853 no 2497 0.265936932659745 3609 315925
SGTC_671 0560-0003 407 µM -0.625217890513814 0.256315125629383 no 2498 0.265914030755701 3482 3238678
SGTC_1862 st057513 3.81 µM -0.625588524495606 0.256204290583664 no 2499 0.265792433806432 3534 5393163
SGTC_887 0885-0007 9.62 µM -0.6256883823837 0.256174433176883 no 2500 0.265759677425343 3571 5719458
SGTC_1840 st055363 71 µM -0.625741909616674 0.25615842933574 no 2501 0.26574211973067 3503 676033
SGTC_3323 9138564 53.9225 µM -0.627672806352923 0.255581468929816 no 2502 0.2651091515709 3580 43912313 YNL103W MET4
SGTC_868 0527-0199 213 µM -0.627872620788238 0.255521802279863 no 2503 0.265043694057077 3484 2849450
SGTC_7 0192-1582 4.227 µM -0.628010963795737 0.255480495895545 no 2504 0.264998378872264 3597 252616
SGTC_20 0481-0013 4.944 µM -0.628079572265431 0.255460012108008 no 2505 0.264975907165756 3544 182045
SGTC_237 nikkomycin 200 µM -0.628848744217615 0.25523042640182 no 2506 0.264724042374165 3599 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1853 st056710 91.2 µM -0.631505669847442 0.254438206688132 no 2507 0.263854971579796 3628 269167
SGTC_1391 3442-0225 151 µM -0.631803580968886 0.25434945847067 no 2508 0.263757616698381 3526 5227075
SGTC_2445 5742597 35.57 µM -0.632090656637522 0.254263953506446 no 2509 0.263663820087967 3502 1774255
SGTC_3290 9121031 71.43 µM -0.632822659399498 0.25404599604455 no 2510 0.263424728897697 3518 17014854
SGTC_260 nsc-65238 3.989 µM -0.633655336938484 0.253798181384792 no 2511 0.263152889322765 3521 3246252
SGTC_2057 5236571 38.335 µM -0.633787209471396 0.253758946207349 no 2512 0.263109850785208 3572 54684039 YBR257W POP4
SGTC_1687 st020778 55.3625 µM -0.634091718881712 0.253668359670721 no 2513 0.263010483410931 3561 4259299
SGTC_2806 7952793 58.44 µM -0.635791047352523 0.253163149428233 no 2514 0.262456311720191 3575 2972490
SGTC_1713 st033146 12.748 µM -0.636076306228397 0.253078393885582 no 2515 0.262363343961852 3593 674619
SGTC_148 3253-0744 288.01 µM -0.63711241590847 0.252770672681395 no 2516 0.262025810876583 3571 6893655
SGTC_1322 1348-1070 12 µM -0.637631773452987 0.252616499337569 no 2517 0.261856703745978 3570 6758089
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.637819330653914 0.252560834416235 no 2518 0.261795647323425 3553 5379071
SGTC_3041 9091929 49.47 µM -0.637891528199055 0.252539408698873 no 2519 0.261772146446492 3636 25236887
SGTC_195 4234-0266 16.654 µM -0.638136345475426 0.252466762586153 no 2520 0.261692464527631 3549 2303354
SGTC_2372 9071633 200 µM -0.638355419767808 0.252401764682519 no 2521 0.261621171861046 3606 21321366
SGTC_1178 0988-0033 191 µM -0.638755668680658 0.252283036239864 no 2522 0.261490945847452 3587 5392207
SGTC_965 1291-5240 308 µM -0.639264023735457 0.252132282029086 no 2523 0.261325594134511 3577 2834598
SGTC_1660 st012960 28.1 µM -0.641214282444287 0.251554368094177 no 2524 0.260691735724996 3553 24207266
SGTC_540 1187-0821 17.3 µM -0.64129730417664 0.251529782068964 no 2525 0.260664770195109 3562 847520
SGTC_191 3914-0123 66.505 µM -0.642463383368783 0.25118459400019 no 2526 0.260286178414714 3475 3144412
SGTC_1502 4534-4282 27.7 µM -0.643172986597957 0.250974656709636 no 2527 0.260055929761313 3563 3278949
SGTC_569 4130-2812 160 µM -0.643552347427134 0.250862460281035 no 2528 0.259932879671016 3509 743552
SGTC_1731 st035964 63 µM -0.643895456982085 0.250761008081821 no 2529 0.259821613971409 3528 6739575
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.644493292627653 0.250584289227608 no 2530 0.259627802839537 3565 521171
SGTC_2803 7707263 71.43 µM -0.644525780159345 0.250574687877712 no 2531 0.259617272910669 3562 2199229
SGTC_1708 st033234 31.827 µM -0.645937960130661 0.25015752130512 no 2532 0.259159767274772 3640 674664
SGTC_2290 7904846 200 µM -0.646385948932298 0.250025259688773 no 2533 0.259014718935386 3583 2962154
SGTC_1160 4092-0570 10.5 µM -0.646472607922797 0.249999679274407 no 2534 0.258986665619795 3590 4994975
SGTC_2939 9044578 71.43 µM -0.646567359015561 0.249971711784084 no 2535 0.258955994521146 3567 2653634
SGTC_182 3448-4371 550.524 µM -0.646814638565332 0.249898730596018 no 2536 0.258875958538354 3610 3491403
SGTC_507 nimesulide 162 µM -0.64688986524296 0.249876530711484 no 2537 0.258851612759719 3638 4495 A COX2 inhibitor.
SGTC_2465 5809242 33.21 µM -0.647652104495906 0.249651647978198 no 2538 0.258604994391103 3590 2731748
SGTC_3030 9087619 49.47 µM -0.64801208230927 0.249545481444516 no 2539 0.258488567835168 3558 25236973
SGTC_2835 9006588 71.43 µM -0.648997038878038 0.249255115569638 no 2540 0.258170145083266 3613 2345538
SGTC_69 0096-0274 206.684 µM -0.649231009986196 0.249186167141808 no 2541 0.258094535382237 3721 6741392
SGTC_3104 9120930 49.47 µM -0.651058885549337 0.248647863886651 no 2542 0.257504237770207 3603 17014836
SGTC_1430 4049-0248 69.1 µM -0.651462372059746 0.248529121961503 no 2543 0.25737402962132 3641 22774488
SGTC_603 3794-0023 45.9 µM -0.651507958029343 0.248515708379877 no 2544 0.257359320835479 3587 3802260
SGTC_1327 1436-0082 2.18 µM -0.651628613229423 0.248480207686963 no 2545 0.25732039229217 3564 15992205
SGTC_2068 5226020 147 µM -0.653782225765209 0.247846999538229 no 2546 0.256626059666192 3606 1810509
SGTC_2257 7960413 200 µM -0.654576358329976 0.247613725138429 no 2547 0.25637027483596 3586 2974689 YIL048W NEO1
SGTC_1695 st026914 34.495 µM -0.654812208513145 0.2475444673476 no 2548 0.25629433465411 3577 3289191
SGTC_227 fluconazole 33.516 µM -0.655256642067661 0.247413986840671 no 2549 0.256151265662451 3574 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1175 0741-0056 27.6 µM -0.655600266347913 0.247313127962798 no 2550 0.256040677053939 3652 765927
SGTC_1815 st051655 58.2 µM -0.65630422587627 0.247106573945117 no 2551 0.255814199543843 3578 5984156
SGTC_2683 piperine 63.03 µM -0.658294016181721 0.24652323410992 no 2552 0.255174611144222 3565 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.658750225974163 0.246389592732268 no 2553 0.255028087245733 3596 6312947
SGTC_2466 5983409 37.09 µM -0.659056237215349 0.246299972043797 no 2554 0.254929828273456 3560 2879657
SGTC_2405 ticlatone 3.52 µM -0.659360871520445 0.246210771975491 no 2555 0.25483203111098 3511 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_630 4356-0227 183 µM -0.659499455329885 0.246170198939222 no 2556 0.254787547863328 3626 779312
SGTC_2705 st078069 42.8 µM -0.66056793761089 0.245857500933016 no 2557 0.254444718208284 3571 1530061
SGTC_819 1013-0258 27.7 µM -0.66248195118601 0.245297886348211 no 2558 0.253831199094212 3633 5753198
SGTC_1870 st057514 26.5 µM -0.662602757184002 0.245262588374646 no 2559 0.253792501934015 3608 5393161
SGTC_2952 9073731 13.78 µM -0.664532975248259 0.244698973803697 no 2560 0.253174625504297 3619 16457353
SGTC_2049 5262831 67.185 µM -0.664814043774903 0.244616961326216 no 2561 0.253084719517385 3647 763417
SGTC_712 r015-0009 80.6 µM -0.665180501893388 0.244510055410175 no 2562 0.252967525009174 3589 6813872 YLR060W FRS1
SGTC_34 0469-0683 81.75 µM -0.665468834662556 0.24442595850385 no 2563 0.252875335322199 3607 3690923
SGTC_1221 2958-7315 257 µM -0.667967203338277 0.24369792198876 no 2564 0.252077263870389 3634 4562705
SGTC_2319 6033012 152.6 µM -0.668143208447397 0.24364667744396 no 2565 0.252021091466026 3579 847246
SGTC_2553 4-methylesculetin 85.09 µM -0.669594750589546 0.243224277484419 no 2566 0.251558080666484 3627 5319502
SGTC_1431 4049-0260 9.09 µM -0.670027957902416 0.243098290545875 no 2567 0.251419983956959 3611 3854841
SGTC_866 0495-0101 262 µM -0.67052613313664 0.242953453035508 no 2568 0.251261226486717 3591 635694
SGTC_2460 5552655 174.22 µM -0.671056497718792 0.242799308240679 no 2569 0.251092269253192 3617 5401989
SGTC_2337 9009472 200 µM -0.672748469023062 0.242307908840632 no 2570 0.250553663152016 3662 5742383
SGTC_1485 3909-9022 254 µM -0.673040847033146 0.242223048112844 no 2571 0.250460652374419 3647 714516
SGTC_1645 Cervolide 78 µM -0.674528447052252 0.24179153193474 no 2572 0.249987703206153 3581 23173 A fragrance.
SGTC_2407 paclitaxel 400 µM -0.675727109616588 0.241444133136348 no 2573 0.249606960300066 3697 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2219 9098279 200 µM -0.677296627745351 0.240989662453203 no 2574 0.24910888504322 3635 902349
SGTC_1839 st053978 48 µM -0.677354021579152 0.240973052279506 no 2575 0.249090681549442 3680 3788398
SGTC_911 3456-4043 236 µM -0.678783300328749 0.240559609983931 no 2576 0.248637588237257 3704 914281
SGTC_760 0568-0725 82.9 µM -0.678976387229352 0.24050378606165 no 2577 0.248576411751589 3646 3916171
SGTC_2256 7954252 200 µM -0.679345523295533 0.240397083683879 no 2578 0.248459479235682 3593 2972920
SGTC_716 1683-5115 658 µM -0.682098422118301 0.23960214526472 no 2579 0.247588359141526 3670 723597
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.683949424695633 0.239068449928906 no 2580 0.247003551336031 3648 688798
SGTC_1709 st033179 39.1045 µM -0.684615344641553 0.238876605816324 no 2581 0.246793340769109 3636 573381
SGTC_3119 9125183 49.47 µM -0.685337418241807 0.238668679641963 no 2582 0.246565512484664 3526 22695334
SGTC_385 1494-0393 12.4 µM -0.685413059919556 0.238646903820798 no 2583 0.246541652583323 3666 3090647
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.68612973313256 0.238440640996787 no 2584 0.246315651403853 3705 5393153
SGTC_3324 9138759 60.749 µM -0.687617759744535 0.23801268997518 no 2585 0.245846760678688 3670 45595710
SGTC_212 3807-4682 38.772 µM -0.688655394602578 0.237714519317086 no 2586 0.245520076236601 3750 3125501 YBL034C STU1
SGTC_435 c-PAF 6.7 µM -0.688785071489309 0.237677270288735 no 2587 0.245479265730263 3650 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2917 7979103 53.79 µM -0.689586567788059 0.237447115617238 no 2588 0.245227108389727 3663 2980565
SGTC_2958 9077254 16.72 µM -0.689686771277967 0.237418350165595 no 2589 0.245195593342672 3674 16457351
SGTC_2296 7971656 126.45 µM -0.689868803414637 0.237366099030111 no 2590 0.245138347901178 3696 666570
SGTC_2327 6189656 200 µM -0.691763881321022 0.236822504514579 no 2591 0.244542811206199 3709 5349088
SGTC_1018 4259-0013 28.1 µM -0.691996540984272 0.236755814354993 no 2592 0.244469750618506 3680 6801262
SGTC_1873 rapamycin 2 nM -0.692040755780721 0.236743141680942 no 2593 0.244455867465983 3660 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_495 decylubiquinone 155 µM -0.693258414926603 0.236394287573411 no 2594 0.24407369756667 3632 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1098 clofazimine 15.1 µM -0.693683785289581 0.236272487521945 no 2595 0.243940268418548 3706 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_201 4262-0159 12.803 µM -0.694638573123473 0.235999220574562 no 2596 0.243640916242051 3646 1341029
SGTC_1635 st007035 42.4 µM -0.69484452009972 0.235940299954842 no 2597 0.243576372233362 3679 3716403
SGTC_991 3996-0057 64.7 µM -0.695358599514036 0.23579325924045 no 2598 0.243415299483091 3660 715343
SGTC_2597 laccaic acid a 100 µM -0.695819510394078 0.235661469143288 no 2599 0.24327093458613 3649 5491415 A textile dye.
SGTC_831 k061-1017 217 µM -0.69766348295967 0.235134621287999 no 2600 0.242693835162118 3719 1240153
SGTC_849 0386-0493 241 µM -0.697761269422984 0.235106700550271 no 2601 0.242663252099631 3640 726119
SGTC_1348 1493-0373 93.8 µM -0.698602123100779 0.234866689177624 no 2602 0.242400358267634 3662 3010129
SGTC_109 0132-0036 33.701 µM -0.698751982770921 0.234823927794734 no 2603 0.242353520682677 3549 67274 A color developer.
SGTC_1089 terbinafine 2.25 µM -0.698958800836203 0.234764920810287 no 2604 0.242288889207002 3663 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2570 licareol 100 µM -0.699248200234764 0.234682366418415 no 2605 0.242198466415975 3663 443158
SGTC_1064 honokiol 6.76 µM -0.701141363357615 0.234142716779214 no 2606 0.241607399436429 3686 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1063 disulfiram 1.84 µM -0.701655910097267 0.233996163128615 no 2607 0.241446887576522 3679 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_416 estradiol valerate 100 µM -0.702458053775833 0.233767797252629 no 2608 0.241196775982986 3691 13791 A steroid.
SGTC_853 0419-0306 21 µM -0.705162285517258 0.232998828354122 no 2609 0.240354624360487 3677 762713
SGTC_2528 xanthyletin 44.79 µM -0.706790002690917 0.232536652681961 no 2610 0.239848494104724 3730 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_932 2857-0803 154 µM -0.706853598016253 0.232518605713479 no 2611 0.239828731274647 3769 674898
SGTC_3127 9126946 49.47 µM -0.708196181020898 0.232137791719509 no 2612 0.239411718712028 3660 27243249
SGTC_2495 cafestol 54.53 µM -0.708980505031083 0.231915484600168 no 2613 0.239168287368167 3692 16667697 An anti-infammatory.
SGTC_3298 9116858 71.43 µM -0.711696011138751 0.231146723945154 no 2614 0.238326519133352 3703 2506942
SGTC_52 0329-0193 875 nM -0.71210737281914 0.231030391468765 no 2615 0.238199144542134 3760 3739292
SGTC_1344 1488-0097 29.1 µM -0.713269221175738 0.230701999031974 no 2616 0.23783958975575 3694 747966
SGTC_1421 4029-0249 71.4 µM -0.713433002544593 0.230655727771814 no 2617 0.237788928624045 3767 2894095
SGTC_80 0159-0065 512.242 µM -0.713787248521096 0.230555664482206 no 2618 0.237679372903932 3643 1548079
SGTC_2915 7971052 15.16 µM -0.714312960006374 0.230407212331794 no 2619 0.237516840036794 3564 5741558
SGTC_626 0214-0009 33 µM -0.717639359808026 0.229469132369856 no 2620 0.23648984110604 3728 3437874
SGTC_1101 ebselen 5.29 µM -0.7178577999685 0.229407604913487 no 2621 0.236422485100649 3761 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1060 3448-7350 82 µM -0.718922570335649 0.229107826310395 no 2622 0.23609431448196 3657 570178
SGTC_2330 7979373 200 µM -0.721183835086766 0.228471912543873 no 2623 0.235398208016007 3677 1863007
SGTC_1222 0366-0074 1.18 µM -0.721209786836078 0.228464620142904 no 2624 0.235390225624414 3742 286520
SGTC_829 1635-0120 117 µM -0.722370086043938 0.228138711536842 no 2625 0.235033486677768 3725 285054
SGTC_156 3474-0145 5.642 µM -0.723159234122958 0.227917202506156 no 2626 0.234791030481511 3640 2265471
SGTC_665 3914-0008 307 µM -0.725330835997394 0.227308272215763 no 2627 0.234124546368325 3688 1069549
SGTC_1189 1431-2119 7.28 µM -0.725988582955192 0.227124017030235 no 2628 0.233922884828633 3735 3107275
SGTC_3285 9112818 20.8695 µM -0.726288484657392 0.227040033279329 no 2629 0.233830968596542 3736 17017947 YPR165W RHO1
SGTC_2145 5634607 200 µM -0.727200827987169 0.226784650536698 no 2630 0.233551469536385 3679 308662
SGTC_1097 itavastatin 7.23 µM -0.727720160123385 0.226639351731594 no 2631 0.233392453395995 3734 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2359 9039622 200 µM -0.729113402530065 0.22624980987928 no 2632 0.232966148460369 3683 6463596
SGTC_2176 5809774 33.9695 µM -0.729632664653724 0.226104724258882 no 2633 0.232807375102781 3723 2870539
SGTC_506 n9-isopropylolomoucine 153 µM -0.730937173944705 0.22574046693702 no 2634 0.232408764252321 3712 6610355
SGTC_1659 st012954 42.1 µM -0.730952944020064 0.225736065500334 no 2635 0.232403947811161 3706 24207262
SGTC_54 0159-0055 9 µM -0.73297126695282 0.225173151309278 no 2636 0.231787977146363 3750 3319099
SGTC_1090 efavirenz 20.7 µM -0.733053212872604 0.225150313243447 no 2637 0.231762987352161 3787 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_501 nsc-95397 161 µM -0.733980216544262 0.224892051687713 no 2638 0.23148039777398 3736 262093
SGTC_2719 novobiocin 32.65 µM -0.736152525674377 0.224287508598276 no 2639 0.23081894003989 3719 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3091 9116372 49.47 µM -0.736237670871052 0.224263831908336 no 2640 0.230793035251005 3761 17169793
SGTC_2721 ifenprodil 61.44 µM -0.736436257539363 0.224208615576888 no 2641 0.230732623053824 3722 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3154 9100113 49.47 µM -0.737463248160449 0.223923187633853 no 2642 0.230420342481134 3749 25237525
SGTC_640 3381-0960 37.1 µM -0.739536160262207 0.223347699805436 no 2643 0.229790745319486 3770 1745025
SGTC_1184 1269-1718 139 µM -0.740027402010725 0.223211443319407 no 2644 0.229641683772672 3769 5403821
SGTC_3139 9095020 49.47 µM -0.741773840094392 0.222727414405395 no 2645 0.229112186424801 3531 25236292
SGTC_333 3486-0131 40.1 µM -0.743567054301944 0.222231044421981 no 2646 0.228569220456003 3803 6744690
SGTC_2959 9079155 11 µM -0.743665748303362 0.22220374380502 no 2647 0.228539357972531 3736 16189457
SGTC_927 2425-1185 123 µM -0.743981630850045 0.222116377618642 no 2648 0.228443794077553 3726 730375
SGTC_1047 2043-3044 82 µM -0.744255532097834 0.222040638412889 no 2649 0.22836094895547 3748 669592
SGTC_1961 st076550 68.7 µM -0.745608182031521 0.221666819758244 no 2650 0.227952069428198 3730 1579337
SGTC_1326 1431-2094 10.8 µM -0.745882151806292 0.221591149225722 no 2651 0.227869303926562 3733 616278
SGTC_926 2268-1401 59.4 µM -0.746060015271091 0.221542031188748 no 2652 0.227815580925137 3735 2931578
SGTC_2478 5763493 32.33 µM -0.747776938278029 0.221068212940025 no 2653 0.227297357316878 3711 1365576 YLR208W SEC13
SGTC_964 1287-0107 19.4 µM -0.751863041402695 0.219942908781038 no 2654 0.226066712973922 3754 51516812 YPR165W RHO1
SGTC_992 3909-8734 162 µM -0.752434900245871 0.219785682684361 no 2655 0.225894782597437 3776 4288319
SGTC_586 0957-0265 8.15 µM -0.752558898111783 0.219751599392456 no 2656 0.225857512175671 3637 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1078 idebenone 36.1 µM -0.753961296928414 0.219366333329681 no 2657 0.225436230980022 3812 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1928 4'-methoxychalcone 40.3 µM -0.757511571040854 0.218392741326021 no 2658 0.224371718128593 3817 641818
SGTC_2685 mycophenolic acid 18.85 µM -0.758695621898097 0.218068593229149 no 2659 0.224017328243023 3756 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3307 9126885 69.2785 µM -0.758714010270595 0.218063561379973 no 2660 0.224011827058135 3762 24824909
SGTC_2423 st077119 87.2 µM -0.759307633420241 0.217901156528152 no 2661 0.223834276138927 3719 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1374 2889-5571 141 µM -0.760316416274037 0.217625331324216 no 2662 0.223532735715913 3803 2853281
SGTC_3106 9121286 49.47 µM -0.760543001189787 0.217563405344971 no 2663 0.223465037855629 3771 15943471
SGTC_3019 9081971 49.47 µM -0.761172506616419 0.217391414003917 no 2664 0.223277018733146 3774 16451803
SGTC_718 1130-0073 349 µM -0.762062178019346 0.217148474921368 no 2665 0.223011447487665 3818 6740020
SGTC_1439 4092-1168 46 µM -0.762190772913468 0.217113372996113 no 2666 0.222973076172035 3764 2886240
SGTC_2695 st077686 51.995 µM -0.762378512718207 0.217062132458491 no 2667 0.22291706341244 3820 2876092
SGTC_3215 9129942 49.47 µM -0.764268097986297 0.216546790033283 no 2668 0.222353746246366 3711 17682944
SGTC_88 0180-0332 8.668 µM -0.765710070225 0.216154000774919 no 2669 0.221924416893285 3845 3101745
SGTC_1545 lovastatin 49.4 µM -0.76797467470658 0.215537962312732 no 2670 0.221251115430901 3859 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2425 5628681 7.85 µM -0.768959867248604 0.215270279372796 no 2671 0.220958567776872 3849 5714958
SGTC_420 mitomycin C 81.9 mM -0.769380379763203 0.215156082281451 no 2672 0.220833766290669 3768 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2805 7950783 58.44 µM -0.769807730640342 0.215040064156477 no 2673 0.220706976647409 3816 1178958 YDL195W SEC31
SGTC_998 3996-0085 177 µM -0.770384517533581 0.21488353443819 no 2674 0.220535917343397 3822 715391
SGTC_3063 1327-0034 4 µM -0.770763353905916 0.214780760995727 no 2675 0.220423606125862 3673 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2954 9074818 52.69 µM -0.771720144260694 0.214521323244752 no 2676 0.22014009855267 3771 16648742
SGTC_329 k048-0121 21.3 µM -0.771807403328709 0.214497671648332 no 2677 0.220114253135687 3779 6832902
SGTC_3155 9099265 49.47 µM -0.771841401689589 0.214488456792919 no 2678 0.220104183572515 3775 25236499
SGTC_2816 7982706 58.44 µM -0.773120911433218 0.214141828104075 no 2679 0.219725413201051 3829 2981853
SGTC_1723 st034307 2.5525 µM -0.773470868568837 0.214047078917624 no 2680 0.219621881394484 3846 867466
SGTC_100 0086-0128 49.5915 µM -0.773983435259326 0.213908348037517 no 2681 0.219470293527044 3810 93297
SGTC_979 1426-2828 121 µM -0.7740184590287 0.213898870443979 no 2682 0.219459937696594 3911 747872
SGTC_3334 9142812 21.919 µM -0.774693846436666 0.213716155317077 no 2683 0.219260294012621 3860 45283678
SGTC_686 1319-0111 510 µM -0.776156869349682 0.213320670071163 no 2684 0.218828184416426 3816 4562600
SGTC_2487 5918373 44.05 µM -0.778181419867523 0.212774096714121 no 2685 0.218231034350866 3808 2876279
SGTC_1812 st052057 4.327 µM -0.778640320692366 0.212650319777168 no 2686 0.218095810191567 3814 3645418
SGTC_857 0438-0306 1.35 µM -0.778667747023224 0.212642923547162 no 2687 0.218087730013205 3865 4686136
SGTC_1568 digitonin 820 nM -0.779209435848543 0.212496873723841 no 2688 0.217928176318273 3790 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1337 1486-1011 40.3 µM -0.779799043197723 0.212337970759197 no 2689 0.217754584818449 3804 X1337
SGTC_1004 4084-0029 199 µM -0.780951378219175 0.212027609631941 no 2690 0.217415546095914 3838 716894 YLR208W SEC13
SGTC_40 0327-0103 19.753 µM -0.781236816659008 0.211950772835007 no 2691 0.2173316118375 3707 409036
SGTC_3231 9132313 49.47 µM -0.781450264129123 0.211893325837079 no 2692 0.217268859027193 3796 4905967
SGTC_1229 0139-0193 12.2 µM -0.781546294396085 0.211867483336516 no 2693 0.217240629877841 3820 3090752
SGTC_3313 9133968 57.047 µM -0.781582981934641 0.211857610917975 no 2694 0.217229845733127 3786 1494643
SGTC_2735 sertaconazole 140 nM -0.781787409436139 0.211802605509286 no 2695 0.217169760807397 3869 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1420 4'-methoxyflavone 42 µM -0.786708797944343 0.210480929059102 no 2696 0.215726176328531 3783 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_266 formosanin C 406 nM -0.787246152130114 0.210336912206265 no 2697 0.215568892479273 3755 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.787743889246736 0.210203564795526 no 2698 0.215423263912272 3789 6708514
SGTC_2523 spermine 47.74 µM -0.787904460054811 0.210160557297451 no 2699 0.215376296076677 3797 1103 A DNA binding polyamine.
SGTC_432 NS 1619 61.3 µM -0.789248377717859 0.20980080331892 no 2700 0.214983425863593 3876 4552 A K+/calcium channel activator.
SGTC_3299 9121982 43.1275 µM -0.791287020481792 0.209255769718187 no 2701 0.214388260411714 3885 17594604 YPL160W CDC60
SGTC_1296 1068-0102 11.9 µM -0.791503757500797 0.20919787386949 no 2702 0.214325042172175 3841 767053
SGTC_1905 st060207 84.5 µM -0.792000742946921 0.209065152304165 no 2703 0.214180121516225 3742 1948547
SGTC_1927 st060202 13.8 µM -0.792107003198862 0.209036781597102 no 2704 0.214149143490991 3744 688887
SGTC_44 0929-0055 61.211 µM -0.794310350664027 0.208449015111155 no 2705 0.213507389879563 3781 1379590
SGTC_291 SEC14.278 35.5 µM -0.795495681350533 0.20813321909056 no 2706 0.213162611056871 3806 1068044
SGTC_1540 guanosine 70.6 µM -0.795793397035943 0.208053946009589 no 2707 0.213076065122658 3722 6802 Guanosine is a purine nucleoside
SGTC_749 1000-0129 128 µM -0.796141333665039 0.207961323132237 no 2708 0.212974945944347 3864 708470
SGTC_2625 euphol 100 µM -0.797150337053861 0.207692857909135 no 2709 0.212681862448629 3828 6708538 A triterpene alcohol.
SGTC_3125 9127534 49.47 µM -0.797577389409658 0.207579293913876 no 2710 0.212557888243892 3672 1639235
SGTC_1156 4092-0367 4.88 µM -0.79777693312006 0.20752624278797 no 2711 0.212499974753537 3851 1357585
SGTC_3204 9114183 49.47 µM -0.798368573203993 0.207368995172497 no 2712 0.212328317481328 3847 17027248
SGTC_3167 9103034 49.47 µM -0.800139772833399 0.206898662506308 no 2713 0.21181490983812 3855 5127859
SGTC_2848 9016370 25.97 µM -0.800607228525142 0.206774637511483 no 2714 0.211679532339735 3803 7894410
SGTC_646 4092-0839 27.3 µM -0.80123592826377 0.206607900792468 no 2715 0.211497537642027 3871 877796
SGTC_39 0986-0283 58.349 µM -0.807212489246566 0.205026844495953 no 2716 0.209772035736023 3918 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_246 cycloheximide 667 µM -0.807696522021204 0.204899112683518 no 2717 0.209632653132565 3721 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1529 apigenin 74 µM -0.807954643068922 0.204831016253138 no 2718 0.209558346587911 3856 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1761 st044296 37 µM -0.809430464555501 0.204441929641055 no 2719 0.209133792392722 3846 1826700
SGTC_2485 5633444 17.78 µM -0.814219218432741 0.203182452316473 no 2720 0.207759688806696 3889 5724239
SGTC_2431 5490079 200 µM -0.815266606799834 0.202907600067048 no 2721 0.20745985944457 3917 5722345
SGTC_3275 9138069 49.47 µM -0.815673550134373 0.202800871252584 no 2722 0.207343435329425 3952 17617007
SGTC_1389 3405-0187 19 µM -0.817192807393623 0.202402712894106 no 2723 0.206909126132297 3822 799890
SGTC_845 0330-0138 4.51 µM -0.818901150965325 0.201955558649145 no 2724 0.206421406603279 3790 9039800
SGTC_2232 chlorophetanol 41.5365 µM -0.819314578209021 0.201847434135749 no 2725 0.206303478615614 3938 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_458 nppb 133 µM -0.820264604207269 0.201599103169429 no 2726 0.206032639948762 3862 4549 A chloride channel blocker.
SGTC_2606 farnesol 9.78 µM -0.820403189188991 0.20156289320878 no 2727 0.205993149006358 3880 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1103 duloxetine 36.1 µM -0.821337259462162 0.201318937770728 no 2728 0.205727095040682 3960 60835 A selective serotonin reuptake inhibitor.
SGTC_619 1652-1634 108 µM -0.821441206993255 0.201291800263774 no 2729 0.205697499976597 3825 5400454
SGTC_2081 5214970 32.255 µM -0.823371990557522 0.200788130769131 no 2730 0.205148243061629 3776 2063512
SGTC_346 4513-0042 7.16 µM -0.825114829938527 0.200334139072431 no 2731 0.204653200512389 3851 2827372
SGTC_2879 9041815 71.43 µM -0.825652767098415 0.200194136633993 no 2732 0.204500546499701 3872 4942971
SGTC_2151 5563267 85.4165 µM -0.827553707289297 0.199699873000964 no 2733 0.203961647136483 3893 5310824
SGTC_2027 5150920 200 µM -0.827788041453155 0.199638994625662 no 2734 0.203895274154537 3844 786715
SGTC_169 k015-0017 16.025 µM -0.828032504090585 0.199575496847048 no 2735 0.203826046096652 3853 1840002
SGTC_1738 st035555 74 µM -0.829409253523562 0.199218121046875 no 2736 0.203436433536099 3929 5331140
SGTC_3033 9090887 49.47 µM -0.829894599858509 0.199092227080265 no 2737 0.203299189169769 3905 19325384
SGTC_1923 st058458 19.1 µM -0.830166601932028 0.199021693435928 no 2738 0.20322229763756 3869 3534982
SGTC_1917 st066507 28.5 µM -0.83300221093049 0.198287280514714 no 2739 0.202421741179612 3861 3156428
SGTC_3076 9116187 49.47 µM -0.833729383386542 0.198099209205198 no 2740 0.202216748176057 3871 27241210
SGTC_1828 st055811 49 µM -0.834911427585225 0.197793722670721 no 2741 0.20188379003818 3923 5877589
SGTC_464 bw-b 70c 158 µM -0.835283463324106 0.197697632982331 no 2742 0.201779062980477 3953 5353454
SGTC_901 1112-0062 60.1 µM -0.836110113428025 0.197484226140974 no 2743 0.201546479687121 3877 1908457
SGTC_1459 k035-0031 35.7 µM -0.837357958658013 0.197162348096611 no 2744 0.201195694844823 3731 3877128 YMR208W ERG12
SGTC_2989 9073649 71.4286 µM -0.837586669277132 0.197103387299318 no 2745 0.201131441160846 3804 21367202
SGTC_1140 3229-1848 2.98 µM -0.837669498230933 0.197082036916975 no 2746 0.201108174330704 3913 2849525
SGTC_1908 st060353 56.5 µM -0.838273812035819 0.196926308496519 no 2747 0.200938470147522 3928 4227716
SGTC_1200 1643-0193 18.4 µM -0.840625699004173 0.196320949323335 no 2748 0.200278828517391 3864 5403974
SGTC_3008 9078912 71.4286 µM -0.841105164707983 0.196197676793957 no 2749 0.200144511004862 3877 16648731
SGTC_12 0849-0099 9.267 µM -0.844635433351432 0.195291476588136 no 2750 0.199157209571985 3790 6071388
SGTC_1265 0819-1001 68.8 µM -0.84720546589199 0.194633365964789 no 2751 0.19844030371946 3869 3106768
SGTC_959 1222-0044 107 µM -0.847573434393239 0.194539250487598 no 2752 0.198337787157546 3864 6083612
SGTC_3271 9137798 49.47 µM -0.848744653793393 0.19423987157769 no 2753 0.198011696551266 3808 6498326
SGTC_1202 1988-0068 29.6 µM -0.848798055908635 0.194226227994053 no 2754 0.197996836070128 3851 2850480
SGTC_3149 9097855 49.47 µM -0.851645774224655 0.193499516633238 no 2755 0.197205362819879 3929 25236625 YMR079W SEC14
SGTC_840 0245-0196 390 µM -0.85343487149873 0.193043805065687 no 2756 0.196709095176502 4004 3827528
SGTC_1321 1326-2144 215 µM -0.857914039788066 0.191905767018957 no 2757 0.195469965529766 3916 3513030
SGTC_2605 digitonin 300 nM -0.858254825791076 0.191819350757708 no 2758 0.195375884000238 3920 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2448 5185112 27.17 µM -0.862547823596236 0.190732777070353 no 2759 0.19419306410942 3954 5718189
SGTC_1678 st019265 80.2 µM -0.863810979037547 0.190413788346897 no 2760 0.193845867819058 3917 5367020
SGTC_2352 9027995 87.8 µM -0.866048935324932 0.189849435037223 no 2761 0.193231663367635 3883 2997347
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.870673555483686 0.188686491152534 no 2762 0.191966210746923 3950 165521
SGTC_544 k015-0020 52.4 µM -0.87069808134524 0.188680335412898 no 2763 0.191959513190787 3939 3008304
SGTC_1578 josamycin 24.2 µM -0.871744296808731 0.188417861348994 no 2764 0.191673944417542 3939 5282165 A P450 substrate.
SGTC_2360 9040895 200 µM -0.871915236478203 0.188374997495593 no 2765 0.191627310478594 3978 4914414
SGTC_635 k038-0028 24.7 µM -0.873867718161776 0.18788583117009 no 2766 0.191095148366955 3943 4035102
SGTC_1345 1488-0192 31.4 µM -0.874116146745754 0.18782364724397 no 2767 0.191027502522 3944 658348
SGTC_1648 st011736 69.8 µM -0.874434492943675 0.187743980886952 no 2768 0.190940839935562 3927 2855514
SGTC_791 1348-1292 225 µM -0.87493574377396 0.187618584830563 no 2769 0.190804434571413 3907 5437054
SGTC_706 4262-0057 46.9 µM -0.875600807556483 0.187452288194619 no 2770 0.19062354312009 3910 883298
SGTC_2817 7995342 71.43 µM -0.878218630205745 0.186798597196426 no 2771 0.189912541808414 3953 18879975
SGTC_1728 st035614 33.7865 µM -0.879554899379581 0.186465464809215 no 2772 0.189550240109033 3938 15945546
SGTC_2662 daunorubicin 22.37 µM -0.879855583774973 0.186390554827256 no 2773 0.189468774414611 3824 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2419 paclitaxel 166.5 µM -0.881408423530397 0.186003990199458 no 2774 0.189048400026176 3872 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2780 5215298 71.43 µM -0.885201019707619 0.185061951054774 no 2775 0.188024111233218 3983 2834131
SGTC_672 1441-0018 53.7 µM -0.88605339620013 0.184850638746051 no 2776 0.187794377258838 3940 251141
SGTC_3044 9093193 49.47 µM -0.886640739595458 0.184705117989662 no 2777 0.187636176389474 3972 25236277
SGTC_592 k241-0073 46.5 µM -0.88777247383853 0.184424919343296 no 2778 0.187331576177146 3954 4230158
SGTC_2199 6590217 200 µM -0.887998922571743 0.184368886152703 no 2779 0.187270665435817 3865 703109
SGTC_1450 4112-4260 37.6 µM -0.888364750845658 0.184278386827499 no 2780 0.187172289914655 3909 1633175
SGTC_2857 9024691 58.44 µM -0.890633366045062 0.183717789715425 no 2781 0.186562946496043 4040 16478292
SGTC_3266 9136860 49.47 µM -0.89063492516908 0.183717404806276 no 2782 0.186562528142743 3832 4871271 YPR165W RHO1
SGTC_2351 9026858 72.31 µM -0.891353371498697 0.183540091640227 no 2783 0.186369812223973 3877 1409300
SGTC_846 0335-0850 148 µM -0.891589026240954 0.183481955086614 no 2784 0.186306627106245 3946 6819598
SGTC_2521 angolensin 13.4 µM -0.89362406069246 0.182980385194777 no 2785 0.185761534206588 4039 821428 A flavenoid.
SGTC_236 1509-0011 5.31 µM -0.898119661777519 0.181875401734963 no 2786 0.184560878911846 4020 3107280
SGTC_949 1165-0505 146 µM -0.898680139662764 0.181737933858147 no 2787 0.184411529282961 3997 6244267
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.899024568416156 0.181653488402596 no 2788 0.184319787222739 3972 77254
SGTC_1482 3346-2049 8.48 µM -0.900708886663019 0.181240888710418 no 2789 0.183871561235834 3968 3826804
SGTC_762 1165-0429 115 µM -0.900935250094963 0.18118548227667 no 2790 0.183811373832676 3962 5967793
SGTC_2970 9090938 41.86 µM -0.902300900499449 0.180851440422788 no 2791 0.183448523676426 4052 17217104
SGTC_490 phenamil 164 µM -0.905222252287545 0.180138166813731 no 2792 0.182673827720511 3953 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1356 1502-0781 85.8 µM -0.906990551980839 0.179707280132102 no 2793 0.182205896754694 3936 567702
SGTC_816 0325-0417 81.3 µM -0.90832510665838 0.179382514511053 no 2794 0.181853240772707 4024 68101
SGTC_422 cantharidin 155 µM -0.908888002693172 0.179245643742528 no 2795 0.18170462363148 3921 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_573 3702-0553 84.7 µM -0.910175852624727 0.178932744201396 no 2796 0.181364888367742 3929 1222756
SGTC_1800 st050079 29.0735 µM -0.91075837489098 0.178791325972854 no 2797 0.181211349508173 3881 3645560
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.912739400429239 0.178310921482669 no 2798 0.180689808263241 4025 4174840
SGTC_2277 7947813 106.88 µM -0.912776457786021 0.178301942722259 no 2799 0.180680061211597 4072 1246798
SGTC_728 3030-5151 22.5 µM -0.912973995040491 0.17825408551686 no 2800 0.180628109322854 4019 3125388
SGTC_1001 4048-4355 44.4 µM -0.913055276020102 0.178234395984673 no 2801 0.180606735314083 3967 21824233
SGTC_1799 st045822 46.1415 µM -0.915750023837467 0.177582395505254 no 2802 0.179899010583969 3941 3674992
SGTC_631 k072-0230 41.5 µM -0.91775339821325 0.177098651201142 no 2803 0.179373992443111 4011 5773147
SGTC_2125 5246583 200 µM -0.920727693617012 0.176382000693088 no 2804 0.178596306889383 3958 835267
SGTC_2744 captopril 92.04 µM -0.924905882453468 0.175378378275095 no 2805 0.177507433246695 4010 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_453 enantio-paf c16 10 µM -0.925083624930081 0.175335764057555 no 2806 0.177461205067033 3866 13871343 A lipid and platelet activating factor
SGTC_1318 1280-3875 124 µM -0.932388371131513 0.173590113710285 no 2807 0.175567926182181 4028 373245
SGTC_3237 9133362 49.47 µM -0.937198686356474 0.172446630149719 no 2808 0.174328182696571 3966 43845137
SGTC_2201 6605497 169.863 µM -0.937739363994679 0.172318404045804 no 2809 0.17418918454748 3938 670741
SGTC_419 nsc-638432 893 µM -0.938514806871095 0.172134607664476 no 2810 0.173989955616757 3988 368090
SGTC_1355 1499-0035 1.68 µM -0.939506183617036 0.171899812683714 no 2811 0.173735459459575 3999 1548538
SGTC_1414 3917-0015 5.4 µM -0.939959982276886 0.171792404500386 no 2812 0.173619043928909 3967 6618702
SGTC_2264 7948757 110.76 µM -0.940257726294443 0.171721955693746 no 2813 0.173542688949076 3973 2971411
SGTC_1657 st012939 43.4 µM -0.941124437933738 0.171516989292261 no 2814 0.173320546701239 4038 24207257
SGTC_1465 k213-0056 144 µM -0.944603652198701 0.170695773106157 no 2815 0.172430630886197 3896 24048857 YMR208W ERG12
SGTC_653 0203-0016 55.2 µM -0.945203089210018 0.170554539602445 no 2816 0.172277601315468 4068 295302
SGTC_981 1488-1094 54.9 µM -0.946103628002084 0.170342504111148 no 2817 0.172047866752606 3993 3449522
SGTC_3021 9087658 49.47 µM -0.947120180009002 0.170103355816539 no 2818 0.171788771385055 4001 25237042
SGTC_1847 st056231 15 µM -0.948748083680901 0.169720832793621 no 2819 0.171374376117181 4018 5393180
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.949786870334598 0.169477028420766 no 2820 0.17111027931185 4075 6708784 An antioxidant flavonoid
SGTC_3286 9117135 37.221 µM -0.950477229907985 0.169315124636859 no 2821 0.170934909213019 4001 3438150
SGTC_173 1273-0061 2.693 µM -0.951478923214845 0.169080383167955 no 2822 0.170680656433891 4022 2847414 YPL266W DIM1
SGTC_449 xestospongin c 11.1929 µM -0.952031586394108 0.168950959018619 no 2823 0.170540481500063 4038 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_880 0833-0487 87.2 µM -0.955068288150896 0.168240951926264 no 2824 0.169771582249396 4024 76075
SGTC_3045 9092950 49.47 µM -0.955093457874786 0.168235075059451 no 2825 0.169765218526488 3990 44120432
SGTC_2768 sulfasalazine 50.2 µM -0.955328333663324 0.16818024038993 no 2826 0.169705841680399 3977 5384001 An antioxidant and salicylic acid derivative.
SGTC_1397 3532-0190 20.1 µM -0.956000966992708 0.168023269411998 no 2827 0.169535872971578 3979 5322280
SGTC_1603 st002045 67.8 µM -0.956257892179313 0.167963336233883 no 2828 0.169470979004427 4030 5887985
SGTC_1308 1187-1617 41.4 µM -0.956931023065869 0.16780637962253 no 2829 0.169301035716664 4046 2882570
SGTC_2105 5350118 200 µM -0.958462684535881 0.167449588049375 no 2830 0.168914749657808 4033 2133313
SGTC_2665 lovastatin 100 µM -0.959293666862912 0.167256220261371 no 2831 0.168705412465111 4059 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_443 clozapine 122 µM -0.961674793810509 0.166702934629844 no 2832 0.168106493903205 3942 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.966182925649396 0.165658650613335 no 2833 0.166976327563935 4111 5377381
SGTC_2723 salbutamol 83.58 µM -0.968192612237436 0.165194483914213 no 2834 0.166474091915731 4079 9884233 β2-adrenoceptor agonist
SGTC_244 nsc-207895 1.295 µM -0.968987323610729 0.165011166103037 no 2835 0.166275756979544 3850 42640
SGTC_1795 st049545 62.3 µM -0.96962773207428 0.164863537556225 no 2836 0.166116042275951 3972 5291882
SGTC_32 0928-0142 34.1 µM -0.969896761838226 0.164801545671729 no 2837 0.166048977156537 4042 2244242
SGTC_1984 st072354 53.1 µM -0.970527430350201 0.164656281430381 no 2838 0.165891829461317 3938 5762938
SGTC_1883 5-benzylidenerhodanine 20 µM -0.973460186248005 0.163981859084744 no 2839 0.165162319294385 4048 1273210
SGTC_3350 9150499 3.57 µM -0.974140185180156 0.163825741503847 no 2840 0.164993469539906 4032 4910996 YPR165W RHO1
SGTC_213 1246-0773 967 nM -0.974541928432275 0.163733552608887 no 2841 0.16489376567643 4046 6251622
SGTC_2932 9016711 44.54 µM -0.974608905907366 0.163718186418201 no 2842 0.164877147131852 4085 7117328
SGTC_2907 7721985 69.9 µM -0.976401402108725 0.163307293891752 no 2843 0.164432793478982 4105 3267881
SGTC_1249 0481-0015 10.2 µM -0.977601624908138 0.163032542559651 no 2844 0.164135696691323 4011 4227577
SGTC_1273 0849-0096 14.1 µM -0.978659838930168 0.162790548841221 no 2845 0.163874041000685 4084 5286025
SGTC_2608 thymoquinone 42.66 µM -0.979253493914751 0.162654893407729 no 2846 0.163727371508142 4054 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1483 3453-0561 55.9 µM -0.984799737392444 0.161391081538802 no 2847 0.162361224831774 4079 4546991
SGTC_2886 9058944 51.95 µM -0.98628169435523 0.161054477934619 no 2848 0.161997450037788 3914 4949929
SGTC_231 b-estradiol 524 µM -0.986893448949798 0.160915661031173 no 2849 0.161847438057284 4052 450 A steroid.
SGTC_1360 1598-0022 39.8 µM -0.990264937160711 0.160152018207979 no 2850 0.161022319916487 4129 761525
SGTC_2150 5556613 200 µM -0.991101790876492 0.159962838271812 no 2851 0.160817939307568 4083 743190
SGTC_1210 3013-0140 750 nM -0.991466845370306 0.159880359510866 no 2852 0.160728836948783 4120 905973
SGTC_2626 ethyl orsellinate 100 µM -0.992745940872841 0.159591585986495 no 2853 0.160416890234219 4072 75653 A natural product.
SGTC_177 1327-0068 8.361 µM -0.993784976486963 0.159357260735744 no 2854 0.160163780886872 4077 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3257 9139206 32.98 µM -0.994044925518164 0.159298671793711 no 2855 0.160100498086269 4078 4910041
SGTC_1329 1447-1697 50.6 µM -0.996878806139423 0.158660869246315 no 2856 0.159411670090737 4085 2840515
SGTC_1037 k284-1091 78.7 µM -1.00090727622947 0.15775709424136 no 2857 0.15843581923398 4063 3334711
SGTC_3111 9122088 49.47 µM -1.00117491414997 0.157697170513921 no 2858 0.15837112611431 3938 16876704
SGTC_3335 9143315 29.6265 µM -1.00120155191078 0.157691207177658 no 2859 0.15836468821485 4101 4899691
SGTC_968 1309-0633 340 µM -1.0015825224899 0.157605936351416 no 2860 0.158272632810892 4144 3761976
SGTC_1248 0469-0687 58.6 µM -1.00160165034764 0.157601655853196 no 2861 0.158268011798073 4087 4017482
SGTC_1621 st003705 32.4 µM -1.00176663477696 0.157564738237303 no 2862 0.158228157629446 4095 24207032
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.00235496067795 0.157433138200857 no 2863 0.158086093354816 4102 4620898
SGTC_767 0929-0023 86 µM -1.00426415673218 0.157006576259975 no 2864 0.157625652711638 4105 1204563
SGTC_2018 5133068 143 µM -1.00628740473885 0.156555362782997 no 2865 0.15713866874779 4055 785362
SGTC_2459 5811157 9.22 µM -1.00639874120487 0.156530557952915 no 2866 0.157111899463588 4067 2870684 YBR192W RIM2
SGTC_2050 5263056 171 µM -1.0098166104156 0.155770344435547 no 2867 0.156291580266058 4103 763468 YGL055W OLE1
SGTC_2060 5238662 140 µM -1.00988922174501 0.15575422044296 no 2868 0.156274183558405 4079 790130
SGTC_2182 6325192 200 µM -1.01212312465262 0.155258700180087 no 2869 0.155739593478339 4042 736248
SGTC_1558 st069300 45.6 µM -1.01486118308749 0.154652769868156 no 2870 0.155086001905443 4036 24208000
SGTC_1251 0490-5699 265 µM -1.01559637445734 0.154490339049003 no 2871 0.154910816028653 4161 3883818
SGTC_1291 0993-0025 5.79 µM -1.01791883590946 0.153977962936788 no 2872 0.154358264698951 4122 4353356
SGTC_149 3970-0822 46.1 µM -1.01913257505575 0.153710638469117 no 2873 0.154070015540395 4120 3114250 YBL034C STU1
SGTC_2107 5363541 170.161 µM -1.01999775825771 0.153520270674772 no 2874 0.153864761962067 4080 244052
SGTC_155 k072-0202 43.6 µM -1.02126961838615 0.153240704634784 no 2875 0.153563358225747 4037 5857737
SGTC_3289 9119912 71.43 µM -1.02223283481122 0.153029205816221 no 2876 0.153335356816239 4166 17014829
SGTC_3341 9147222 25.867 µM -1.02310341860333 0.152838213426063 no 2877 0.15312947538397 4112 1939759
SGTC_1429 4049-0205 9.46 µM -1.02325172692375 0.152805692678491 no 2878 0.153094420720833 4132 22774478
SGTC_924 2046-0044 21.3 µM -1.02337669063 0.152778294453214 no 2879 0.153064888000072 4105 3623589
SGTC_3124 9127567 49.47 µM -1.0264398514032 0.152107716880039 no 2880 0.152342150851987 4116 17592030
SGTC_858 0438-0351 2.77 µM -1.02695879145844 0.151994306057954 no 2881 0.152219934347965 4082 2799119
SGTC_995 3931-2021 34.6 µM -1.02697498826963 0.151990767259051 no 2882 0.152216120855781 4118 730143
SGTC_1131 3454-3128 32.3 µM -1.02723181325741 0.151934661553305 no 2883 0.15215566063503 4159 710982
SGTC_2452 5863136 48.41 µM -1.02868885693502 0.15161661785366 no 2884 0.151812953917639 4075 2184096
SGTC_2124 5246320 200 µM -1.0339133623709 0.150479852649744 no 2885 0.150588333797773 4139 579342
SGTC_319 1348-1596 45.5 µM -1.03405403379045 0.150449323597306 no 2886 0.150555451740547 4226 5380505
SGTC_2767 sibutramine 71.45 µM -1.03474047412823 0.15030040887308 no 2887 0.150395064372056 4160 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_649 1123-0311 367 µM -1.0357874424492 0.150073471285575 no 2888 0.150150658637247 4026 693629 YIL048W NEO1
SGTC_1071 trifluoperazine 6.31 µM -1.03896550945422 0.149386003196886 no 2889 0.149410388660349 4204 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1281 0884-0031 11.8 µM -1.03958498898972 0.149252244818937 no 2890 0.149266376950756 4146 1548255
SGTC_93 0109-0045 59.227 µM -1.04058693350268 0.149036073706026 no 2891 0.149033649048275 4235 88733
SGTC_1848 st056003 16.4 µM -1.0417849053027 0.14877788405819 no 2892 0.148755706994689 4158 146492
SGTC_167 3672-0051 66.205 µM -1.04302610844268 0.148510692588714 no 2893 0.148468100469405 4048 3237971
SGTC_3049 9092223 49.47 µM -1.0434937080344 0.14841011656375 no 2894 0.148359846698005 4117 8623917
SGTC_3117 9124945 49.47 µM -1.04369517484552 0.148366797100141 no 2895 0.148313221484992 4040 17592065
SGTC_2016 5121758 140 µM -1.04472411734858 0.148145685435784 no 2896 0.148075247482131 4054 2795203
SGTC_2624 nerol 100 µM -1.04566092161463 0.147944565416115 no 2897 0.147858805585647 4051 637566 A natural product oil.
SGTC_2708 st078559 56 µM -1.04626488968808 0.147814998061198 no 2898 0.147719375456948 4079 17250902
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.04837052412976 0.1473638773098 no 2899 0.14723396424409 4192 91467 include heat shock
SGTC_1466 k213-0079 57.5 µM -1.04902650029222 0.147223526665516 no 2900 0.147082960952619 4060 3657981
SGTC_545 4218-0007 221 µM -1.04990131909444 0.147036492593476 no 2901 0.146881742528966 4146 2840508
SGTC_1087 pterostilbene 9.05 µM -1.04997730104531 0.147020255366053 no 2902 0.146864274522375 4188 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2603 homopterocarpin 100 µM -1.05072030773238 0.146861539335299 no 2903 0.146693533109167 4134 101795 A weak amylase inhibitor.
SGTC_832 4083-0019 164 µM -1.05100186165983 0.146801425741303 no 2904 0.146628867406799 4221 1990758
SGTC_2368 9071271 200 µM -1.05105282589467 0.146790546310479 no 2905 0.146617164276685 4152 27209959
SGTC_1650 st011916 45.8 µM -1.05202958327612 0.14658214060545 no 2906 0.146392988534047 4066 242528
SGTC_969 1313-0238 134 µM -1.05236176464576 0.146511310045759 no 2907 0.146316802001185 4178 5212874
SGTC_373 0844-0104 25.9 µM -1.05602939413249 0.145730793854256 no 2908 0.145477392906721 4167 5375804
SGTC_1338 1486-1223 76 µM -1.05622897189519 0.145688401616284 no 2909 0.14543180871472 4166 3444526
SGTC_1204 4049-0315 18.3 µM -1.05904350387034 0.145091450778676 no 2910 0.14478998378857 4218 588402
SGTC_2543 pimpinellin 60.67 µM -1.0621904010713 0.14442595853836 no 2911 0.144074628311977 3974 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2927 9011802 47.9 µM -1.06244429103582 0.144372356801151 no 2912 0.144017017897521 4168 43912568
SGTC_1954 st077032 68.9 µM -1.06576044642897 0.143673474919789 no 2913 0.143265972590676 4127 698907
SGTC_2356 9061756 188.97 µM -1.06718300483244 0.143374370752452 no 2914 0.14294460271204 4188 20104043
SGTC_3310 9130229 44.1445 µM -1.07183413338031 0.142399370423019 no 2915 0.141897269437133 4204 7761258
SGTC_2268 7933382 153.85 µM -1.07224727682917 0.142312981975921 no 2916 0.141804490402199 4193 935025 YOR257W CDC31
SGTC_2532 xanthone 78.9 µM -1.07634119707953 0.141458858379887 no 2917 0.140887345197714 4174 7020 An insecticide.
SGTC_611 3453-1652 23.7 µM -1.07746506420244 0.141224992486001 no 2918 0.140636275117496 4200 1560575
SGTC_2749 bexarotene 57.39 µM -1.07767105581444 0.141182156062512 no 2919 0.140590289878453 4205 82146 An retinoic acid receptor inhibitor.
SGTC_2473 5854593 8.94 µM -1.07812072435119 0.141088677077102 no 2920 0.140489942051575 4053 2872951
SGTC_2742 clothiapine 36.27 µM -1.08139901334894 0.140408441119051 no 2921 0.139759830179272 4168 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_53 0973-0023 39.979 µM -1.08659770772987 0.139334298678972 no 2922 0.138607319278093 4043 674768
SGTC_1856 st057054 55.7 µM -1.08687961481502 0.139276211911333 no 2923 0.138545008242914 4195 1266018
SGTC_1197 1601-0112 267 µM -1.09132874220972 0.138361654091746 no 2924 0.137564127456807 4140 7350313
SGTC_2472 5377652 49.4 µM -1.09552967527307 0.13750187990979 no 2925 0.136642326027461 4261 1610903
SGTC_1992 st073643 23.3 µM -1.09576628827351 0.137453562800601 no 2926 0.13659053250387 4161 3161292
SGTC_2088 5278280 127.392 µM -1.0959611684392 0.137413776372225 no 2927 0.136547884193956 4249 791502
SGTC_601 0986-0029 62.9 µM -1.09659457043276 0.137284516332873 no 2928 0.136409331021563 4139 24747981
SGTC_1606 st000094 49.2 µM -1.0972156277497 0.137157856158717 no 2929 0.136273571588167 4226 1242210
SGTC_737 1950-0117 57.9 µM -1.09733599305524 0.137133317757999 no 2930 0.136247271147453 4181 5393513
SGTC_3249 9135183 49.47 µM -1.09850157459563 0.136895850380941 no 2931 0.135992765234777 4184 4902779
SGTC_377 3970-0964 33.1 µM -1.09957057503882 0.136678306972467 no 2932 0.135759634204912 4149 16481235
SGTC_2267 7931562 200 µM -1.11133559043766 0.134299720068534 no 2933 0.133211962667995 4144 934880
SGTC_50 0929-0078 56.389 µM -1.11157570847537 0.134251472163794 no 2934 0.133160310856719 4055 1377751
SGTC_1151 3909-8316 15.3 µM -1.11238299053098 0.134089348959977 no 2935 0.132986757418218 4246 800431
SGTC_1028 k015-0029 4.8 µM -1.11301241241789 0.133963038052226 no 2936 0.132851549308955 4155 4588309
SGTC_27 0485-0001 32.618 µM -1.11385475905886 0.133794125870392 no 2937 0.132670750309113 4156 2054479
SGTC_1696 st025591 34.7925 µM -1.11392834261995 0.133779377428586 no 2938 0.132654964586185 4212 2787147
SGTC_190 3970-0790 3.722 µM -1.11779522178034 0.133005906336204 no 2939 0.131827231367153 4164 2832352
SGTC_3308 9128332 17.569 µM -1.11942973726235 0.132679890426689 no 2940 0.131478425241754 4219 17332805 YDL196W YDL196W
SGTC_2834 9001755 58.44 µM -1.119619877193 0.132642001415427 no 2941 0.131437890726145 4133 2989575
SGTC_799 1310-0557 151 µM -1.1196917679903 0.132627677743502 no 2942 0.131422567110421 4269 5354492
SGTC_2303 7774051 200 µM -1.12111054992816 0.13234521468261 no 2943 0.131120404262988 4248 2953184
SGTC_2098 5376439 882.5 nM -1.12296448348792 0.131976743240342 no 2944 0.13072628943093 4261 2844116
SGTC_2783 7738165 71.43 µM -1.1257126811142 0.131431838624609 no 2945 0.13014357718297 4206 17201110
SGTC_2819 7996655 46.38 µM -1.12818670046617 0.130942627519176 no 2946 0.129620539711886 4179 6456960
SGTC_1962 st076595 64.5 µM -1.12881975802615 0.130817649532542 no 2947 0.129486938002985 4199 279619
SGTC_2321 7390090 138.78 µM -1.12984700819162 0.130615025670066 no 2948 0.12927034818986 4252 649046
SGTC_2978 9011784 42.97 µM -1.13188745282038 0.130213194267226 no 2949 0.128840877203496 4205 2994934
SGTC_491 tetrandrine 80.3 µM -1.13334069148894 0.129927525312739 no 2950 0.128535604928679 4238 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1835 st008666 49.2 µM -1.14161630039881 0.128309027215776 no 2951 0.126806772742302 4162 690455
SGTC_2378 9074213 121.43 µM -1.14500094769781 0.127651127028936 no 2952 0.126104382399661 4200 657714
SGTC_587 k089-0003 57 µM -1.14825039151135 0.127021717289444 no 2953 0.125432606018808 4131 9659696
SGTC_3300 9124615 50.48 µM -1.15189489542367 0.126318358838287 no 2954 0.124682133046844 4293 24824903
SGTC_1290 0986-0249 10.2 µM -1.15337247414746 0.12603397330527 no 2955 0.124378767252133 4097 53329
SGTC_658 3253-0951 102 µM -1.15442597788112 0.125831481121462 no 2956 0.124162784933207 4242 1184878
SGTC_2440 5628896 157.78 µM -1.1567442673138 0.125386685969904 no 2957 0.12368842900973 4217 5522048
SGTC_1932 st074806 40.9 µM -1.15747601893991 0.125246517691082 no 2958 0.123538965739213 4318 17251235
SGTC_1036 k216-0215 33.5 µM -1.16091268240232 0.12458968253963 no 2959 0.12283870537091 4221 622330
SGTC_739 1486-1183 203 µM -1.16167919122402 0.124443511931997 no 2960 0.122682900630969 4251 4346692
SGTC_359 0081-0058 15.9 µM -1.16355010686642 0.12408723838554 no 2961 0.122303190425213 4348 3494159
SGTC_2210 7115885 190.385 µM -1.16542798052818 0.123730358109017 no 2962 0.121922898364852 4346 2927039
SGTC_2021 4019055 173 µM -1.16617185003879 0.123589188419005 no 2963 0.121772485734812 4095 44827708 YER133W GLC7
SGTC_325 2810-4341 181 µM -1.16629053861885 0.12356667443659 no 2964 0.121748498616332 4251 774970
SGTC_2004 4023728 41.89 µM -1.16652782142019 0.123521672982238 no 2965 0.121700553403274 4230 360084 YDR527W RBA50
SGTC_1813 st051246 8.6015 µM -1.17100362902611 0.122674971275514 no 2966 0.120798659222377 4205 5291959
SGTC_1845 st056753 3.01 µM -1.17168884322448 0.122545707498545 no 2967 0.120661001964209 4231 5375839
SGTC_3260 9137109 49.47 µM -1.17349248908112 0.122205911606831 no 2968 0.120299183555077 4208 17478346
SGTC_2091 4-phenylthiadiazole 200 µM -1.17364678817276 0.122176873342599 no 2969 0.120268266082144 4269 270010
SGTC_2800 7887935 81.82 µM -1.17458768623886 0.121999906194942 no 2970 0.120079856043187 4263 2961002
SGTC_606 k015-0008 38.6 µM -1.17498255151797 0.121925692311966 no 2971 0.120000848283411 4350 1970475
SGTC_104 0074-0074 590.992 µM -1.17499286311492 0.121923754699594 no 2972 0.119998785548787 4040 3943124
SGTC_3352 9151559 45.5865 µM -1.17764641662156 0.121425854464109 no 2973 0.119468798484933 4259 17159339
SGTC_3161 9100388 49.47 µM -1.1793690229188 0.121103398957535 no 2974 0.119125632241629 4344 25236368
SGTC_567 1080-0542 68.4 µM -1.17988689459837 0.121006576181112 no 2975 0.119022601449181 4151 5950415
SGTC_2591 skatole 100 µM -1.18289045707062 0.120446095477559 no 2976 0.118426282086054 4302 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2471 5466956 24.79 µM -1.18329524270803 0.120370700362718 no 2977 0.118346078778093 4255 724419
SGTC_1575 cyproterone acetate 48 µM -1.18592022135486 0.119882580264309 no 2978 0.117826903326196 4288 9880 An androgen receptor antagonist and liver toxin.
SGTC_2499 avocadenofuran 51.48 µM -1.18707336201611 0.119668593176557 no 2979 0.117599342247589 4237 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2669 eugenol 100 µM -1.18906457795103 0.119299719834732 no 2980 0.117207127957132 4278 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1404 3909-7820 48.3 µM -1.19119886505851 0.118905234315169 no 2981 0.11678776250064 4247 23741373
SGTC_1521 st012942 49.4 µM -1.19451946112787 0.118293313586291 no 2982 0.116137416354047 4239 24207259
SGTC_1771 st048882 4.1505 µM -1.1968290775741 0.117869011551886 no 2983 0.115686591085969 4315 4580403
SGTC_794 k038-0031 316 µM -1.20289456442749 0.116759845319162 no 2984 0.114508562021312 4280 6624242
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.20293533728802 0.11675241450643 no 2985 0.114500672180535 4281 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_906 1165-0455 526 µM -1.2059449618241 0.116204838941099 no 2986 0.113919356347821 4273 3252859
SGTC_1113 artemisinin 1.17947 µM -1.2075725241544 0.115909478267446 no 2987 0.113605866537431 4334 2240 An anti-malaria and mitochondrial poison.
SGTC_1747 st037496 66.6 µM -1.21733254917075 0.114149465290253 no 2988 0.111738857473884 4267 723305
SGTC_2156 5649887 115 µM -1.22142614699229 0.113416966733684 no 2989 0.110962356159866 4330 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.22256076961055 0.113214534733824 no 2990 0.110747819020582 4309 7104
SGTC_1888 azatryptophan 97.5 µM -1.22366373150637 0.113017998645578 no 2991 0.110539553423143 4353 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_560 2332-1943 155 µM -1.2255591398783 0.112680826004291 no 2992 0.110182311020138 4281 21177716
SGTC_1981 st071826 47 µM -1.22632628578636 0.112544563454584 no 2993 0.11003795671543 4348 11838600
SGTC_3157 9099274 49.47 µM -1.22690605179641 0.112441661950088 no 2994 0.109928951857187 4328 17217662
SGTC_947 3447-0010 211 µM -1.22980389028826 0.111928338002686 no 2995 0.109385275538245 4273 748350
SGTC_320 4092-0846 5.34 µM -1.23373256110997 0.111235091164951 no 2996 0.10865128821853 4271 1359356
SGTC_2526 patulin 37.61 µM -1.23487726343671 0.111033678424006 no 2997 0.108438093249906 4346 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3233 9132340 49.47 µM -1.23553146084973 0.110918688396277 no 2998 0.108316387562889 4319 17682950
SGTC_328 k915-0120 63.5 µM -1.23915039438229 0.110284119893988 no 2999 0.10764490360337 4318 6624543
SGTC_1735 st034310 56.75 µM -1.23950640204805 0.110221836024255 no 3000 0.107579009675613 4369 871153
SGTC_2398 5228213 48.84 µM -1.23953286609013 0.110217207123275 no 3001 0.107574112572083 4305 80771 YMR134W ERG29
SGTC_427 1354-0053 47.3 µM -1.24687042525055 0.108939147482796 no 3002 0.106222506223943 4375 6813657
SGTC_2141 5621638 7.665 µM -1.25195677975793 0.108059478230093 no 3003 0.105292806605876 4352 2856238
SGTC_1806 st050005 60.3 µM -1.25417583926051 0.107677305309865 no 3004 0.104889049799059 4381 5194765
SGTC_67 0335-0847 266 µM -1.25584276799304 0.107390863146742 no 3005 0.104586491044915 4419 4552207 YOR254C SEC63
SGTC_2136 5328288 199.296 µM -1.25631253583001 0.107310238347169 no 3006 0.104501339329981 4315 262395
SGTC_1851 st056236 18.9 µM -1.25760791300874 0.107088142863774 no 3007 0.104266795097703 4318 5393171
SGTC_446 go6976 132 µM -1.2591883870749 0.106817616070582 no 3008 0.1039811475505 4362 3501 A protein kinase C inhibitor.
SGTC_2278 7948257 134.34 µM -1.26059416222419 0.106577406833035 no 3009 0.10372755150208 4338 1247028
SGTC_2252 omeprazole 400 µM -1.26060574781542 0.106575428787852 no 3010 0.103725463374993 4338 4594 A proton pump inhibitor.
SGTC_1182 1222-0449 220 µM -1.26404248671777 0.105989832680187 no 3011 0.103107388889072 4335 658318
SGTC_919 tnp00227 403.569 nM -1.26639906420611 0.105589634499837 no 3012 0.102685122896714 4290 1269246 A methoxyflavone. YNL221C POP1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.26769592834396 0.10536986540085 no 3013 0.102453279702055 4315 364106
SGTC_2832 7992762 51.95 µM -1.26812105032812 0.105297895472495 no 3014 0.102377362625094 4286 2985177
SGTC_729 4092-0585 94.1 µM -1.26837488340317 0.105254940418178 no 3015 0.102332053344467 4351 2169061
SGTC_2234 tolnaftate 200 µM -1.27114828322338 0.104786436015255 no 3016 0.101837950519966 4430 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3064 1327-0027 10 µM -1.27282002624299 0.104504762578619 no 3017 0.101540956566696 4282 16000455 YPR107C YTH1
SGTC_1642 st009582 77.7 µM -1.27394841439816 0.10431494982129 no 3018 0.101340849352169 4312 6739311
SGTC_879 0831-1030 162 µM -1.27677281594207 0.103840936446951 no 3019 0.100841232702368 4350 1549252
SGTC_3210 9128157 49.47 µM -1.27857973136604 0.103538506248639 no 3020 0.100522545613882 4324 17590849
SGTC_193 1273-0060 1.558 µM -1.27980516464561 0.103333764976422 no 3021 0.100306833523181 4183 2847393 YHR072W ERG7
SGTC_2843 9000894 45.46 µM -1.29337942865417 0.10108545807481 no 3022 0.0979399306955735 4319 2242070
SGTC_284 0988-0104 32.6 µM -1.2948793167089 0.100839235942288 no 3023 0.0976809322998535 4334 4666532
SGTC_2247 cerulenin 830 nM -1.30081629846956 0.0998689103129305 no 3024 0.0966606708791574 4405 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1571 st070080 73.4 µM -1.30336517564611 0.099454427112456 no 3025 0.0962250598415738 4371 4315245
SGTC_2871 9038510 12.99 µM -1.30362004079806 0.0994130517124565 no 3026 0.0961815820804753 4351 4945164
SGTC_370 0180-0345 38.7 µM -1.3061698288962 0.0989998056554998 no 3027 0.0957474052921189 4209 3989527
SGTC_2602 kawain 100 µM -1.31410920178239 0.0977211156231229 no 3028 0.0944047289876927 4357 5369129
SGTC_130 0136-0219 337.655 µM -1.31634940070267 0.0973625162470164 no 3029 0.0940283985780427 4203 234244
SGTC_1843 st055809 45.5 µM -1.32044407289509 0.0967095590062346 no 3030 0.0933433985035098 4435 16413835
SGTC_1700 st030840 7.9285 µM -1.32940272235476 0.095292194042427 no 3031 0.0918575700856654 4418 5499307
SGTC_2807 7945238 51.95 µM -1.33052114583521 0.0951163256056524 no 3032 0.0916733119842619 4374 17148797
SGTC_426 0988-0037 14.6 µM -1.33286745567816 0.0947481530440279 no 3033 0.0912876520884134 4422 5383008
SGTC_3016 9080866 49.47 µM -1.33412298163937 0.0945515733441312 no 3034 0.0910817776161356 4351 17066299
SGTC_157 1348-1695 65.819 µM -1.3377037093289 0.0939925849208487 no 3035 0.0904965206690195 4321 5380510
SGTC_1007 4101-0031 70 µM -1.3395460387397 0.0937059302569377 no 3036 0.0901964886088577 4383 1146276
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.3405811010102 0.0935451646350405 no 3037 0.0900282483306069 4362 2724 A muscle relaxant with antifungal properties.
SGTC_2242 6630449 61.2675 µM -1.34148794867293 0.0934044807606128 no 3038 0.0898810399446546 4428 691249 YDR170C SEC7
SGTC_993 3909-8757 62.7 µM -1.34211075212279 0.093307952670322 no 3039 0.089780044066002 4332 4288324 YLR208W SEC13
SGTC_3216 9129716 49.47 µM -1.34253922138212 0.0932415871749356 no 3040 0.0897106110643114 4315 8056934
SGTC_1967 st070177 51.4 µM -1.35023207871661 0.0920559706188286 no 3041 0.0884707757112257 4415 5729214
SGTC_800 3448-7362 155 µM -1.35403570751136 0.0914738991334475 no 3042 0.0878624929937951 4477 15991913
SGTC_1712 st032288 53.4 µM -1.35564164475847 0.0912289623071142 no 3043 0.0876066073969859 4220 2883011
SGTC_3297 9117502 71.43 µM -1.36156604409939 0.0903295813666851 no 3044 0.0866674387324866 4429 7453720
SGTC_466 geldanamycin 89.2 µM -1.36166333559804 0.0903148667334382 no 3045 0.0866520785931649 4418 5288382 HSP90 inhibitor.
SGTC_1637 st007924 17.4 µM -1.36247124713307 0.090192744738617 no 3046 0.0865246061252793 4321 683336
SGTC_2728 chlorpromazine 9.18 µM -1.36271054937052 0.0901565959367874 no 3047 0.0864868758875148 4496 2726 A thorazine and dopamine antagonist.
SGTC_1380 2291-0730 164 µM -1.36521949530344 0.0897782443627861 no 3048 0.0860920363697272 4409 2999191
SGTC_2140 5586273 200 µM -1.36621418887006 0.0896285707442849 no 3049 0.0859358726452819 4385 854421
SGTC_547 1120-0019 610 nM -1.37510273588415 0.0882993206128401 no 3050 0.0845497981539854 4372 3676939
SGTC_502 l-744,832 89.3 µM -1.37603334725342 0.0881610051877257 no 3051 0.0844056546243177 4434 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_409 arachidonic acid 100 µM -1.37644096047908 0.0881004731117737 no 3052 0.0843425770145303 4412 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2155 5570423 76 µM -1.37740996147816 0.0879566972629165 no 3053 0.0841927673953911 4385 797402
SGTC_796 1234-0020 70.7 µM -1.37962295606792 0.0876289996610224 no 3054 0.0838513827847113 4354 46495034
SGTC_2158 5657123 3.6195 µM -1.37968698513637 0.0876195318910383 no 3055 0.083841520925391 4404 2858827
SGTC_2748 diazoxide 86.69 µM -1.37997544221983 0.0875768881455323 no 3056 0.0837971031072603 4505 3019 A potassium channel activatior.
SGTC_81 0411-0046 9.971 µM -1.38006633187738 0.0875634547790839 no 3057 0.0837831112035058 4406 12925265
SGTC_1152 3909-8331 15.9 µM -1.38423685036246 0.086948710644633 no 3058 0.0831429716146669 4396 16001939
SGTC_1196 1588-0294 184 µM -1.38573375986472 0.0867288507746132 no 3059 0.0829141077533543 4453 6144269
SGTC_1822 st052468 42 µM -1.38779598821871 0.0864266400107164 no 3060 0.0825995883957021 4437 2873678
SGTC_982 1491-0518 27.5 µM -1.3894639959529 0.0861827771368103 no 3061 0.0823458509214293 4367 3091256
SGTC_1999 st074831 12.5 µM -1.38995511687451 0.0861110733918011 no 3062 0.082271253531115 4408 17112523
SGTC_2226 7298446 200 µM -1.38998485147951 0.0861067335672747 no 3063 0.0822667387138749 4435 3283010
SGTC_2863 9028737 58.44 µM -1.39083043291227 0.085983387760239 no 3064 0.0821384261406197 4425 6460917
SGTC_334 1502-1024 68.5 µM -1.39087336616669 0.0859771285723013 no 3065 0.0821319152669552 4440 3296216
SGTC_609 0986-0026 86.3 µM -1.39239960700325 0.0857548411765038 no 3066 0.0819007117094471 4406 2848610
SGTC_2073 5212005 126 µM -1.39865722401522 0.0848479551540954 no 3067 0.0809578987128556 4332 691789
SGTC_478 N-arachidonylglycine 10 µM -1.3986833678335 0.0848441814000733 no 3068 0.0809539769748026 4443 5283389
SGTC_936 3005-4620 401 µM -1.39894617039054 0.0848062539081759 no 3069 0.0809145628950365 4460 777207
SGTC_3068 9116768 49.47 µM -1.39904951825894 0.0847913422950277 no 3070 0.0808990671628406 4392 41904888
SGTC_133 0724-0033 378.92 µM -1.39914477880423 0.0847775993077791 no 3071 0.0808847860087654 4280 280309
SGTC_727 3032-0951 202 µM -1.39957836161063 0.0847150685630539 no 3072 0.0808198087158936 4476 3652836
SGTC_2919 7978188 46.38 µM -1.40343357580225 0.0841605948746852 no 3073 0.0802437933021925 4452 2980291
SGTC_3075 9116269 49.47 µM -1.40505158449585 0.0839286991017398 no 3074 0.0800029697705288 4443 17015205 YNL244C SUI1
SGTC_1062 mesoridazine 14.2 µM -1.40616411535541 0.0837695278884496 no 3075 0.0798376986044342 4479 4078 A neuroleptic.
SGTC_892 0929-0076 29 µM -1.40791916536619 0.0835188917960384 no 3076 0.0795775036602612 4422 5751038
SGTC_450 aminopyrene 156 nM -1.41071805893319 0.08312035253953 no 3077 0.0791638819648624 4391 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_624 k048-0052 28 µM -1.42401883699061 0.0812459593134596 no 3078 0.0772205096331875 4442 6835531
SGTC_150 3970-0969 77.2 µM -1.42936615752371 0.0805014485551214 no 3079 0.0764495100452812 4489 6615640
SGTC_1751 st044839 27.194 µM -1.43038280201091 0.0803604854477333 no 3080 0.0763035907403939 4499 5291326
SGTC_2111 5486399 200 µM -1.43078792735195 0.0803043646876836 no 3081 0.0762455020646916 4425 689674
SGTC_2697 mebhydrolin 72.4 µM -1.43163486029727 0.0801871373732184 no 3082 0.0761241737767182 4484 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2172 5754775 163.918 µM -1.43517714503117 0.0796982373555784 no 3083 0.0756183123169083 4448 2263357
SGTC_3274 9138298 49.47 µM -1.43522698008136 0.0796913753293945 no 3084 0.0756112138591572 4437 17015756
SGTC_2788 5282734 71.43 µM -1.43527013230521 0.0796854338545804 no 3085 0.0756050677070542 4477 743706
SGTC_3026 9090633 49.47 µM -1.43866260232209 0.0792193848546918 no 3086 0.0751230699981862 4453 25236842
SGTC_928 2764-0428 58.7 µM -1.44121735145311 0.0788697842592719 no 3087 0.0747616439322177 4481 662578
SGTC_107 0358-0022 2.6945 µM -1.44443008808047 0.0784318030660643 no 3088 0.074309016123406 4487 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2295 7971645 200 µM -1.44500257691784 0.0783539516004962 no 3089 0.0742285809083778 4517 2978226 YKL099C UTP11
SGTC_2730 imipramine 71.33 µM -1.44804229823378 0.0779415679879402 no 3090 0.0738026106942321 4433 3696 A tricyclic antidepressant.
SGTC_1218 1348-1416 30.7 µM -1.45021508047014 0.0776478084326977 no 3091 0.0734992754938627 4434 6787668
SGTC_1013 4112-3890 241 µM -1.45028570050084 0.0776382747474982 no 3092 0.0734894324776013 4437 705171
SGTC_1824 st053723 68.6 µM -1.45206268924276 0.0773986741657158 no 3093 0.0732420875493662 4483 675225
SGTC_1975 st070967 30.8 µM -1.45342963961491 0.0772147436773498 no 3094 0.0730522510112841 4454 261391
SGTC_465 cgp-37157 41 µM -1.4589229384813 0.0764789385535578 no 3095 0.0722931594352562 4509 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2095 5432005 200 µM -1.45996460793404 0.0763400147772267 no 3096 0.0721499005467707 4480 783734
SGTC_3225 9130819 49.47 µM -1.4646795238646 0.0757136037416611 no 3097 0.0715041870036512 4433 4547121
SGTC_1408 3909-7976 48.8 µM -1.46691167689919 0.0754184149731586 no 3098 0.0712000418035681 4515 24152374
SGTC_1786 berberine 21.6 µM -1.47079426104266 0.0749070575064958 no 3099 0.070673382477769 4384 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1631 benzylvanillin 81.9 µM -1.47658308714331 0.074149554759575 no 3100 0.0698937140374359 4515 75506
SGTC_304 1310-0298 97 µM -1.4790334459527 0.0738306787377202 no 3101 0.0695656880378501 4227 1550234
SGTC_3062 9077494 49.47 µM -1.48104592014857 0.0735695712942853 no 3102 0.069297168648945 4427 16459633
SGTC_1904 st060225 78 µM -1.48223301753854 0.0734158833629179 no 3103 0.0691391520289154 4460 66595
SGTC_1988 st071872 53.4 µM -1.48684310341063 0.0728213648466786 no 3104 0.0685281271543856 4506 16414116
SGTC_1124 fisetin 1.16336 µM -1.4872161749409 0.0727734150742712 no 3105 0.0684788626873531 4497 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1127 asiatic acid 681.4 nM -1.49130628186076 0.0722493099972447 no 3106 0.0679405502108066 4446 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1715 st032160 10.2275 µM -1.49154308519333 0.0722190549077191 no 3107 0.0679094840965136 4401 5289825
SGTC_468 gf-109203x 121 µM -1.49156252912452 0.0722165710925466 no 3108 0.0679069337440284 4566 2396 A protein kinase C inhibitor.
SGTC_1223 0764-0573 147 µM -1.49222938418084 0.0721314250238688 no 3109 0.0678195108291551 4480 1609797
SGTC_2451 5856223 45.7 µM -1.4932238068798 0.0720045970934327 no 3110 0.0676893061666291 4496 2179896
SGTC_442 cape 100 µM -1.49583462330641 0.071672429239908 no 3111 0.067348378174465 4513 5281787
SGTC_3173 9105693 49.47 µM -1.49586943772894 0.0716680078408861 no 3112 0.0673438409904452 4469 17096658
SGTC_2793 7325131 81.82 µM -1.49760830527381 0.0714474394089462 no 3113 0.0671175238385826 4447 4176441
SGTC_3109 9122853 49.47 µM -1.50058093263295 0.0710715805113965 no 3114 0.0667319930481664 4511 1234709
SGTC_1177 0983-0204 23.6 µM -1.50707953485725 0.0702551876653889 no 3115 0.0658951358947186 4519 766818
SGTC_2362 9071156 126 µM -1.5073353367495 0.070223200468915 no 3116 0.0658623621532594 4494 653133
SGTC_788 1182-0090 188 µM -1.51101666709494 0.0697641016537521 no 3117 0.0653921022353904 4506 5715185
SGTC_520 3584-0023 682 µM -1.5117704385869 0.0696703843740552 no 3118 0.0652961360856496 4498 1340790
SGTC_1193 1488-0126 41.5 µM -1.51887640246677 0.0687916491755048 no 3119 0.0643968049062585 4480 1384710
SGTC_1942 st076330 65.2 µM -1.52022666699044 0.0686256436244591 no 3120 0.0642270087004454 4549 24208414
SGTC_1951 sophoraflavanone G 9.2 µM -1.52226669106896 0.0683754232151078 no 3121 0.0639711352839391 4444 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_372 0155-0182 15.9 µM -1.52771336575266 0.0677108066840579 no 3122 0.0632918600728841 4388 771486
SGTC_1068 loratadine 26.9 µM -1.53519923063826 0.066805519746536 no 3123 0.0623674486357616 4550 3957 A H1 histamine antagonist.
SGTC_3000 9075062 71.4286 µM -1.53646060184912 0.0666539047615879 no 3124 0.0622127267125561 4496 17057871
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.54071661471923 0.0661443028377728 no 3125 0.0616928856577852 4442 17037758
SGTC_2876 9059903 25.97 µM -1.54219887973851 0.0659675313081857 no 3126 0.0615126361194669 4507 6916095
SGTC_1640 st009078 66.4 µM -1.54252645820039 0.0659285144856382 no 3127 0.0614728567757176 4479 690618
SGTC_2207 7258803 200 µM -1.54937944537502 0.0651163709006084 no 3128 0.0606452659650572 4549 3666799
SGTC_119 0121-0043 24.815 µM -1.54955002351661 0.0650962552614804 no 3129 0.060624778064667 4534 1092378
SGTC_3294 9122953 26.2835 µM -1.55024097106372 0.0650148237406123 no 3130 0.0605418447057531 4509 16459826
SGTC_2551 apiole 73.87 µM -1.55208562547859 0.0647978095718858 no 3131 0.0603208684828365 4453 10659 A possible DNA adduct former.
SGTC_2981 9013952 38.96 µM -1.55568670123951 0.0643757826115883 no 3132 0.0598913052181388 4467 2996344
SGTC_863 0466-0191 129 µM -1.55619907304125 0.0643159093185507 no 3133 0.0598303808709109 4569 765160 YPR165W RHO1
SGTC_772 k072-0172 35.3 µM -1.55792803202133 0.064114190883923 no 3134 0.0596251546368022 4565 5861980
SGTC_2940 9060638 45.86 µM -1.55911918049562 0.0639755054338311 no 3135 0.059484087367934 4502 4027022
SGTC_691 1548-0686 185 µM -1.56096873686466 0.0637606239959646 no 3136 0.0592655637317494 4506 46495133
SGTC_513 4245-1575 41.7 µM -1.5627186934244 0.063557831367833 no 3137 0.0590593877676589 4355 719745
SGTC_2311 7694451 200 µM -1.56297551346549 0.0635281122187939 no 3138 0.0590291772072158 4520 2163142
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.56463437361565 0.0633364098021575 no 3139 0.0588343321487457 4548 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3084 9116877 49.47 µM -1.56656205021266 0.0631142082721083 no 3140 0.0586085470781173 4475 27241325
SGTC_1559 coumarin 343 70.1 µM -1.5681642681277 0.0629299844702192 no 3141 0.0584214005034676 4567 108770 A hepatotoxic, DNA x-linker.
SGTC_1906 st060206 94.7 µM -1.56860223149698 0.0628797002023512 no 3142 0.0583703260855295 4540 5133468
SGTC_1664 st014217 9.02 µM -1.57488751416705 0.0621615060049582 no 3143 0.0576412055880547 4607 3982782
SGTC_1910 st062352 60.4 µM -1.58229034405549 0.061323839352728 no 3144 0.0567916520234555 4454 2245730
SGTC_1953 st076800 12.1 µM -1.58368028446278 0.0611675486758889 no 3145 0.0566332467947745 4503 297591
SGTC_747 3448-8087 38.7 µM -1.58455133861661 0.0610697625015575 no 3146 0.056534154249764 4575 5168703
SGTC_2513 baicalein 25.65 µM -1.58493596612478 0.0610266224035129 no 3147 0.0564904419024715 4518 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_536 3852-0578 10.6 µM -1.58850099340995 0.0606278991894975 no 3148 0.0560865482972277 4564 2869208
SGTC_528 3492-0019 172 µM -1.6005934418992 0.0592906081220487 no 3149 0.0547334978734218 4542 2869262
SGTC_1244 0416-0015 52.5 µM -1.60513328402115 0.0587945648911774 no 3150 0.0542322379129443 4530 96201
SGTC_2346 9031566 143.75 µM -1.60529341285454 0.0587771281541854 no 3151 0.0542146240682813 4524 4771086
SGTC_801 0866-0028 10.1 µM -1.60909628901248 0.0583642171814618 no 3152 0.0537976442933003 4594 6849771
SGTC_2180 6301957 200 µM -1.61649748294221 0.0575671405953662 no 3153 0.0529933985836639 4571 845462
SGTC_2420 aureobasidin a 50 nM -1.61806279126808 0.0573996656132684 no 3154 0.0528245331397893 4598 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2671 danthron 100 µM -1.62461947824547 0.0567023168001206 no 3155 0.0521218320794891 4548 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1622 st003707 19.4 µM -1.62930098560348 0.0562085028788877 no 3156 0.0516246588106571 4567 10140899
SGTC_2880 9042983 58.44 µM -1.63155936279266 0.0559715006617812 no 3157 0.0513861724026566 4513 6464714
SGTC_852 0418-0143 439 µM -1.63842021482343 0.0552563306704045 no 3158 0.0506670325423409 4536 5369229
SGTC_2949 9072542 2.23 µM -1.63854821859751 0.0552430565614195 no 3159 0.0506536920232483 4535 16457352
SGTC_2197 6588183 93.1375 µM -1.64140494728556 0.0549474659986142 no 3160 0.0503566918034728 4582 884136
SGTC_2891 9063876 19.48 µM -1.64593193317502 0.0544816123520474 no 3161 0.0498888867860887 4598 6472478
SGTC_1760 st045453 10.4495 µM -1.64808138100689 0.0542615178999168 no 3162 0.0496679862365863 4568 3323419 YIL048W NEO1
SGTC_151 3013-0144 2.285 µM -1.64822661513331 0.0542466719442971 no 3163 0.0496530885971564 4316 906558 YHR107C CDC12
SGTC_1286 0929-0070 131 µM -1.64924065664332 0.0541431053027415 no 3164 0.0495491708847014 4610 1420408
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.65387515876521 0.0536717622764302 no 3165 0.0490764404564735 4597 15053
SGTC_411 enrofloxacin 100 µM -1.6547352926682 0.0535846426709186 no 3166 0.0489891023639028 4606 71188 A bacterial gyrase inhibitor.
SGTC_2825 7998094 58.44 µM -1.65674629188809 0.0533813935505877 no 3167 0.0487853898047472 4540 2987815
SGTC_1710 st031758 61.5 µM -1.66405515537612 0.0526478371586433 no 3168 0.0480507038298212 4605 5394341
SGTC_1963 st076565 50.3 µM -1.66831285865907 0.0522242127209591 no 3169 0.0476268183202403 4597 4914280
SGTC_2177 5811945 192 µM -1.66882829897001 0.0521731126885237 no 3170 0.0475757063303051 4582 5343475
SGTC_86 0417-1630 471.922 µM -1.67180549996209 0.0518787338451984 no 3171 0.0472813409666647 4591 3634867
SGTC_217 ketoconazole 989 nM -1.68152075674341 0.0509272840738185 no 3172 0.0463309040799314 4380 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1912 st060209 90.8 µM -1.68314309322259 0.0507697649353883 no 3173 0.0461736969908597 4568 688787
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.68538707683813 0.0505525272995644 no 3174 0.0459569576626425 4668 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_172 1112-0046 2.638 µM -1.69637800265479 0.0494991824760586 no 3175 0.0449071584192489 4578 2802135 YIL048W NEO1
SGTC_756 0508-1999 28.3 µM -1.70135688397199 0.0490278189816069 no 3176 0.0444379961822774 4612 6753853
SGTC_327 1273-0057 3.96 µM -1.7135202056915 0.047891359911901 no 3177 0.0433084396702556 4514 3108138
SGTC_909 3448-9333 149 µM -1.71520802528444 0.0477353411256109 no 3178 0.0431535470150496 4519 3344074
SGTC_1997 st073024 93.8 µM -1.7194829163642 0.0473419989990679 no 3179 0.0427632378638044 4654 686268
SGTC_617 3770-0098 35 µM -1.72029187070534 0.0472678584056844 no 3180 0.0426897002024925 4540 5962639
SGTC_2972 9093619 59.92 µM -1.72488735441822 0.0468484469234908 no 3181 0.0422738874644831 4567 25236256
SGTC_2682 pyrogallin 40.03 µM -1.72489431536064 0.0468478138976479 no 3182 0.0422732601127131 4613 822798 An ATP competetive kinase inhibitor.
SGTC_2564 betulinic acid 100 µM -1.7256204587804 0.0467818163295822 no 3183 0.0422078581330821 4580 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3217 9129673 49.47 µM -1.72689462538073 0.0466661904243498 no 3184 0.042093294931796 4561 17248312
SGTC_3093 9117344 49.47 µM -1.72956943097871 0.0464242076658764 no 3185 0.0418536158017924 4615 24824913
SGTC_861 0443-0273 110 µM -1.73000055679976 0.0463852992520421 no 3186 0.0418150878732357 4600 6149169
SGTC_1393 3470-5649 58.2 µM -1.73244435448396 0.0461652449451586 no 3187 0.0415972382758227 4609 4108395
SGTC_2002 4023503 131 µM -1.73897089629839 0.0455816634296693 no 3188 0.0410199411657068 4585 4736863 YCR052W RSC6
SGTC_1011 4112-3381 17.4 µM -1.74538024930303 0.0450143476136764 no 3189 0.0404593506633935 4632 2877139
SGTC_2381 9035592 200 µM -1.74567167615296 0.0449886880223157 no 3190 0.040434009754012 4620 4749657
SGTC_3178 9107506 49.47 µM -1.74886305691616 0.0447084626049622 no 3191 0.0401573468931291 4589 8897194
SGTC_2804 7954240 19.48 µM -1.75162603046759 0.0444669911671543 no 3192 0.0399190667879379 4604 828705
SGTC_1015 4130-4525 82 µM -1.75177644051785 0.0444538762237073 no 3193 0.0399061284078813 4609 1363237
SGTC_1235 benzylparaben 21.5 µM -1.75470132163451 0.0441994614115287 no 3194 0.0396552049274201 4648 7180
SGTC_769 0302-0231 76 µM -1.76377037649763 0.0434180624523031 no 3195 0.0388853234384157 4545 571869 YER009W NTF2
SGTC_886 0866-0150 153 µM -1.76700270135311 0.0431422725761044 no 3196 0.0386138879500829 4634 271463
SGTC_1275 0867-0008 21.1 µM -1.78229568342437 0.0418565646027814 no 3197 0.0373505131304034 4605 3422836
SGTC_1256 0570-0116 285 µM -1.7871615327134 0.0414540517889808 no 3198 0.0369556922988579 4610 410638
SGTC_2699 st077704 54.6 µM -1.78857463130799 0.0413377469737183 no 3199 0.0368416732343154 4611 645852
SGTC_1877 wortmannin 25 µM -1.78861868915293 0.0413341250569816 no 3200 0.0368381229563916 4631 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1647 st011722 22.4 µM -1.78864821642108 0.0413316978169709 no 3201 0.0368357437408404 4625 2854783
SGTC_2716 st080858 38.6235 µM -1.78904799999343 0.041298845642679 no 3202 0.0368035427882434 4604 5296050
SGTC_3272 9137413 49.47 µM -1.78933559098229 0.0412752259748512 no 3203 0.0367803927339217 4570 17614870
SGTC_3312 9133330 71.43 µM -1.80469107708814 0.0400299065888427 no 3204 0.0355615184461318 4637 17617324
SGTC_978 1416-0512 87.4 µM -1.80508465188724 0.0399983937316559 no 3205 0.0355307182050855 4645 6814003
SGTC_57 miconazole 162.5 nM -1.80724154235427 0.0398260530157189 no 3206 0.0353623131358894 4488 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1764 st044502 93.5 µM -1.80810756772794 0.0397570255723897 no 3207 0.0352948802987515 4627 8407
SGTC_2353 9059630 146.67 µM -1.80956995083935 0.0396406856478692 no 3208 0.0351812516694784 4658 4779114
SGTC_326 k292-0812 17.5 µM -1.81875510392751 0.0389162763785863 no 3209 0.0344744003487711 4633 3579357
SGTC_524 r073-0010 27.8 µM -1.81932919232496 0.0388713598344442 no 3210 0.0344306111266349 4584 2772106
SGTC_734 2023-0417 80 µM -1.82052988208346 0.0387775546370955 no 3211 0.034339174940024 4630 3935732
SGTC_2249 haloperidol 116.36 µM -1.82095646262684 0.0387442719932398 no 3212 0.0343067376129155 4557 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_503 tyrphostin 8 294 µM -1.82276672650646 0.0386032905078831 no 3213 0.0341693646131717 4637 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2048 5246248 200 µM -1.8229538254568 0.0385887432996065 no 3214 0.0341551923139489 4658 677046
SGTC_22 0964-0034 14.468 µM -1.82625105790932 0.0383331110417044 no 3215 0.0339062268391001 4640 138402
SGTC_163 TUB2.036 7.546 µM -1.82717435777612 0.0382617761692656 no 3216 0.0338367789998906 4580 15992207 YJR013W GPI14
SGTC_1936 st074407 74.3 µM -1.83599283012525 0.0375858938608293 no 3217 0.0331793585311507 4652 809813
SGTC_2651 TUB2.036 5 µM -1.84025176778528 0.0372629804243541 no 3218 0.0328656414688661 4514 15992207 YFL037W TUB2
SGTC_2380 9035439 200 µM -1.84395472952015 0.0369840665515645 no 3219 0.0325948689939869 4665 6462575
SGTC_108 0509-0257 621.132 µM -1.84777806865561 0.0366978787141618 no 3220 0.032317227417019 4619 536624
SGTC_2341 7987486 176.74 µM -1.84953044019685 0.0365673153995251 no 3221 0.0321906282644595 4651 1258686
SGTC_283 0987-0079 11.7 µM -1.84960540950019 0.0365617381767409 no 3222 0.032185221291259 4638 411556
SGTC_3188 9110789 49.47 µM -1.85121810657804 0.0364419325401259 no 3223 0.0320690909545858 4605 849217
SGTC_2444 5485484 36.41 µM -1.86133989333616 0.0356973115382491 no 3224 0.0313480964403567 4666 6790631
SGTC_2007 4011539 71.82 µM -1.86623037556647 0.0353420310932937 no 3225 0.0310045705052094 4627 45595301
SGTC_2786 7743617 45.45 µM -1.87141843110492 0.0349683081438379 no 3226 0.0306435530940863 4581 583674
SGTC_2616 abietic acid 100 µM -1.87152713100192 0.0349605127449184 no 3227 0.0306360264661111 4665 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2724 maprotiline 69.64 µM -1.87377152185308 0.0347998750663849 no 3228 0.0304809615767072 4586 4011 A tricyclic antidepressant.
SGTC_1788 fluconazole 20 µM -1.88439532044212 0.0340477017476741 no 3229 0.0297557611765651 4636 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_940 3232-1287 54.8 µM -1.88538305658863 0.0339784537232267 no 3230 0.0296890699406995 4643 1585493 YIL048W NEO1
SGTC_477 mead ethanolamide 10 µM -1.8861029661726 0.0339280554451427 no 3231 0.0296405403467777 4675 16061185
SGTC_2314 7727897 200 µM -1.88818292829535 0.0337827901314473 no 3232 0.0295006984271447 4626 900724
SGTC_2905 7799065 20.05 µM -1.89081181575489 0.0335999201816466 no 3233 0.029324734667284 4568 1296806
SGTC_33 0986-0033 35.816 µM -1.89453522622737 0.0333423082244595 no 3234 0.0290770016183456 4650 2848082
SGTC_758 0868-0029 16 µM -1.89772256209563 0.0331230798332513 no 3235 0.02886631941147 4594 762687
SGTC_3174 9107204 49.47 µM -1.9063794136688 0.0325336389215482 no 3236 0.0283004988286553 4658 3938802
SGTC_702 1488-0190 94 µM -1.90976701865213 0.0323053462874431 no 3237 0.0280816087923298 4685 949357
SGTC_1625 st003711 30.1 µM -1.92012422919189 0.0316155547123561 no 3238 0.0274211047508937 4655 24207034 YER133W GLC7
SGTC_2280 7785178 200 µM -1.92356848425695 0.0313888815372143 no 3239 0.0272043472953081 4657 2954328
SGTC_537 1334-0398 209 µM -1.92480902178152 0.0313075691890505 no 3240 0.0271266274593613 4682 5846986
SGTC_1693 xanthone 101.9 µM -1.93456700254243 0.0306740274372812 no 3241 0.0265217262651262 4704 7020 An insecticide.
SGTC_2563 tomatine 8.54 µM -1.94435806792218 0.0300490450496246 no 3242 0.0259261433666396 4590 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_467 ro 31-8220 72.8 µM -1.94494476399098 0.0300119328850412 no 3243 0.0258908133173217 4650 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2005 4024620 188 µM -1.95544488267429 0.0293541372211352 no 3244 0.025265291468654 4627 236743
SGTC_3137 9097352 49.47 µM -1.9568717688842 0.0292656788019347 no 3245 0.0251812732316603 4627 44120435
SGTC_787 4152-0075 138 µM -1.95965678932458 0.0290936619185925 no 3246 0.0250179594516045 4691 9566539
SGTC_2416 tofa 880 nM -1.97126509460874 0.028385697775448 no 3247 0.0243467808470838 4643 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3052 9092717 49.47 µM -1.97223952937547 0.0283269270587523 no 3248 0.0242911345482502 4677 25237534
SGTC_2076 5212012 200 µM -1.98000384907429 0.0278622494458506 no 3249 0.0238515480892454 4670 604802
SGTC_2639 lactacystin 53 µM -1.98289663507967 0.0276907540796917 no 3250 0.0236894883077725 4680 3870 A proteasome inhibitor.
SGTC_168 3970-0862 530.542 µM -1.98908835616528 0.0273266406392741 no 3251 0.0233457256594664 4617 3135186
SGTC_492 tmb-8 126 µM -1.99311590660669 0.0270919447699348 no 3252 0.0231243782931456 4714 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2385 9074692 200 µM -2.00552568702919 0.0263793469674107 no 3253 0.0224534387323373 4675 17046906
SGTC_841 0251-0215 91.2 µM -2.01172269597358 0.0260294068508829 no 3254 0.0221245883845202 4720 3888614
SGTC_487 nimodipine 119 µM -2.01253571796408 0.0259837855956045 no 3255 0.0220817477209161 4710 4497 L-type voltage-gated calcium channels inhibitor
SGTC_127 0180-0333 59.125 µM -2.01720157543018 0.0257232610443798 no 3256 0.0218372408732667 4622 771601
SGTC_134 0269-0018 6.916 µM -2.02437176188045 0.0253271676773559 no 3257 0.0214659574817238 4655 4378915
SGTC_1974 st069448 26.9 µM -2.03092560506908 0.024969604276026 no 3258 0.021131270957116 4683 6323587 YNR016C ACC1
SGTC_1119 parthenolide 318.541 nM -2.03191907382444 0.0249157739705302 no 3259 0.0210809246210505 4701 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1757 st041620 31.8375 µM -2.0352682165072 0.0247350198456611 no 3260 0.0209119461947307 4678 5289815
SGTC_3246 9135460 32.98 µM -2.04342214985206 0.0242995445651446 no 3261 0.0205053333307636 4707 41446951
SGTC_1396 3511-0007 98.6 µM -2.0734706752175 0.0227499334818441 no 3262 0.0190642487430211 4710 X1396
SGTC_2852 9023854 51.95 µM -2.08144803573037 0.0223528154729167 no 3263 0.018696457889011 4698 19798528
SGTC_2126 5251174 33.877 µM -2.08894277456471 0.0219850658976347 no 3264 0.0183564373826873 4669 790722
SGTC_580 1123-0028 41 µM -2.09320946626322 0.0217780002015691 no 3265 0.0181652300439537 4723 1677248 YPR107C YTH1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -2.13149379857854 0.0199926704331266 no 3266 0.0165242413985198 4674 6708760
SGTC_2844 9010103 25.97 µM -2.13493457178192 0.0198384775811383 no 3267 0.0163831774487712 4660 2480525
SGTC_1491 4138-0063 26.5 µM -2.13923306033811 0.0196472666203174 no 3268 0.0162083989700967 4745 23883227
SGTC_743 1275-0778 158 µM -2.15046104831376 0.0191551765717197 no 3269 0.0157593819462661 4711 2849257 YMR203W TOM40
SGTC_1686 st019653 115.5 µM -2.15210041990801 0.0190842117508 no 3270 0.0156947230470651 4726 97252
SGTC_2988 9073640 71.4286 µM -2.15575467960501 0.0189268309757371 no 3271 0.0155514130130606 4699 9102229
SGTC_1173 0443-0020 122 µM -2.1580613634069 0.0188280567341943 no 3272 0.0154615305942637 4704 5331295
SGTC_323 4013-0906 34.3 µM -2.15931750232306 0.0187744524441821 no 3273 0.0154127716030014 4738 2910086
SGTC_792 4534-1957 155 µM -2.15986309618169 0.0187512103354059 no 3274 0.0153916346838943 4685 1717904
SGTC_1741 st038134 10.228 µM -2.1662755383417 0.0184798726144242 no 3275 0.0151450689063938 4701 1272587
SGTC_2884 9058502 51.95 µM -2.17992596448913 0.0179133837055062 no 3276 0.0146314749689283 4710 6471554
SGTC_2557 derrustone 83.84 µM -2.18867465735432 0.0175581574914227 no 3277 0.0143102476115842 4701 629853 An antioxidant.
SGTC_2435 5706476 10.6 µM -2.19153055629207 0.0174435079436573 no 3278 0.0142067105139538 4716 5725375
SGTC_1685 st024049 53.0905 µM -2.19239294151462 0.0174090135489161 no 3279 0.0141755729325439 4742 1941139
SGTC_2912 7964298 10.93 µM -2.19265863838785 0.0173983977313098 no 3280 0.0141659914446459 4706 2975850
SGTC_178 4092-0806 87.505 µM -2.19320561024249 0.0173765610819702 no 3281 0.0141462842612157 4613 2169044
SGTC_280 3448-3607 3.04 µM -2.19511466784524 0.0173005294704715 no 3282 0.0140776866518171 4710 626179
SGTC_90 0870-0863 4.608 µM -2.20510352499326 0.0169073228701757 no 3283 0.0137234153955169 4735 1738164
SGTC_159 3970-0959 50 µM -2.20602313396172 0.0168715101061629 no 3284 0.0136911899830544 4721 6615653
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -2.21045391372378 0.0166998680589748 no 3285 0.0135368378123191 4734 75037 A free radical scavenger.
SGTC_2707 st078556 66.6 µM -2.21173181066276 0.0166506426014305 no 3286 0.0134926005754265 4679 17250899
SGTC_1920 st075728 45.7 µM -2.22033911057851 0.0163223072557732 no 3287 0.013197878466939 4706 3400306
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.22508457352384 0.0161436688639112 no 3288 0.0130377805724154 4749 688664
SGTC_1122 capsaicin 818.572 nM -2.23330754267889 0.0158380885745704 no 3289 0.0127643352316357 4725 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.239024204652 0.015628581808323 no 3290 0.0125771706492097 4748 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_312 4092-0653 6.84 µM -2.24043990803639 0.0155770673641971 no 3291 0.0125311889378588 4643 1148278
SGTC_1689 st020265 53.493 µM -2.25908162762882 0.0149122113690848 no 3292 0.0119391538791859 4735 5758320 YPR016C TIF6
SGTC_2080 5212524 12.4 µM -2.28034008412182 0.0141839431379336 no 3293 0.0112937630942249 4708 260183
SGTC_1294 1000-1494 117 µM -2.28873108116847 0.0139050366027201 no 3294 0.0110474909849151 4752 712797 YDL207W GLE1
SGTC_670 4204-0025 119 µM -2.29305486876886 0.0137631743810643 no 3295 0.010922423118529 4724 719039
SGTC_2560 caryophyllene 100 µM -2.30503718748523 0.013376543874911 no 3296 0.0105822453986483 4760 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1334 1486-0610 236 µM -2.31937032610898 0.012926411804553 no 3297 0.0101874825959036 4758 3742339
SGTC_2502 avocadyne acetate 18.59 µM -2.32796142095514 0.0126629356607443 no 3298 0.00995707614824932 4723 3952079
SGTC_1743 st037606 46.3785 µM -2.33206949334137 0.0125385983318103 no 3299 0.0098485178046417 4705 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1745 st081495 74 µM -2.33634921212365 0.0124101913615675 no 3300 0.00973652430934366 4641 13842402 YBL026W LSM2
SGTC_2995 9067767 71.4286 µM -2.34722467928254 0.0120890008000351 no 3301 0.00945692282283917 4723 11673567
SGTC_3014 9081533 49.47 µM -2.3694499661843 0.0114549587233002 no 3302 0.00890728263677331 4754 21367265
SGTC_3234 9132280 49.47 µM -2.39603315862096 0.0107347037109184 no 3303 0.00828679546040627 4760 17612295
SGTC_2310 7668677 200 µM -2.4117457065037 0.0103277934489531 no 3304 0.00793817517532294 4703 2197143
SGTC_2764 methyldopa 94.69 µM -2.43047610788001 0.00986035535315798 no 3305 0.00753950009687714 4738 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_538 2922-0838 53.3 µM -2.44044972250183 0.00961907342361906 no 3306 0.00733449385074972 4769 777039
SGTC_2174 5790901 200 µM -2.49649894805889 0.00835682640151697 no 3307 0.00627130203877823 4749 786020
SGTC_908 3448-7491 47.7 µM -2.4987476041576 0.00830937151989991 no 3308 0.0062316520929036 4761 1203031
SGTC_1135 dihydrocapsaicin 536.708 nM -2.50595934395712 0.00815877013077197 no 3309 0.00610598303593805 4719 107982 A Capsaicinoid.
SGTC_1539 benzyladenosine 56 µM -2.51695282832934 0.00793380929587585 no 3310 0.0059187338259888 4784 92208 A nucleotide analog.
SGTC_3136 9095672 49.47 µM -2.52484310548416 0.00777572989989302 no 3311 0.00578749764367847 4705 17217380
SGTC_2507 purpurin 79.67 µM -2.57543448747933 0.0068264406209662 no 3312 0.00500571184267972 4751 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_386 1509-0011 3.07 µM -2.58365569118885 0.00668225419571643 no 3313 0.00488796665424127 4770 3107280
SGTC_2582 agaric acid 100 µM -2.58418220800181 0.00667311234944508 no 3314 0.00488051060092734 4526 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2664 lyso-paf C-16 73.48 µM -2.60383704922291 0.00633966148585638 no 3315 0.00460932874246208 4768 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_751 0833-0568 350 µM -2.60613424756198 0.00630166784606968 no 3316 0.00457852817324726 4768 6954252
SGTC_2906 7926292 26.41 µM -2.61354566975931 0.00618046013808779 no 3317 0.00448040534027685 4754 2966319
SGTC_1966 st070145 16.1 µM -2.63290103098346 0.00587360381883718 no 3318 0.00423295061901808 4767 3748532
SGTC_2062 5245942 200 µM -2.66444666118624 0.00540237908911979 no 3319 0.00385575473181099 4773 1376160
SGTC_2890 9046729 58.44 µM -2.67138962013439 0.00530329374350024 no 3320 0.00377689557186736 4770 903329
SGTC_1683 st010134 710 nM -2.67739518080361 0.00521889347800352 no 3321 0.00370985322558468 4749 3818134
SGTC_885 0865-0106 16.8 µM -2.69305979538711 0.00500434544663418 no 3322 0.00353997850462817 4768 2793380
SGTC_1492 4158-0558 28.5 µM -2.70952718021714 0.00478730612939215 no 3323 0.0033689592094967 4791 3967268
SGTC_1784 st039334 36.3 µM -2.71617762130461 0.00470206015501955 no 3324 0.00330202383643621 4770 3496984
SGTC_3340 9146634 11.102 µM -2.74117007274582 0.00439368287496602 no 3325 0.00306104048640134 4780 4907387
SGTC_2087 5276107 200 µM -2.74228417437969 0.00438036688411767 no 3326 0.00305067655500346 4779 144405
SGTC_324 1315-0088 19.6 µM -2.79710856406128 0.0037680338165277 no 3327 0.00257811021694953 4787 6787421
SGTC_1266 0828-0227 32.9 µM -2.82857109959939 0.00345238172359814 no 3328 0.00233781569732807 4764 3913820
SGTC_3144 9087057 49.47 µM -2.84003548834581 0.00334340525285332 no 3329 0.00225542576237235 4751 17249618
SGTC_522 1273-0010 11.6 µM -2.84157049755059 0.00332905118393285 no 3330 0.00224459627208354 4778 5705015
SGTC_2991 9074669 71.4286 µM -2.86739069090918 0.00309576606012262 no 3331 0.00206935873025565 4735 17333109
SGTC_2038 4100038 30.985 µM -2.92045100614686 0.00266198888762006 no 3332 0.00174762575270618 4769 3596803
SGTC_1844 rapamycin 4 nM -2.9229693772612 0.00264283676993164 no 3333 0.00173355306573562 4689 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_101 0490-5701 117.494 µM -2.97947487509546 0.00224456646924269 no 3334 0.00144371454176468 4762 4661669
SGTC_684 1140-0066 328 µM -2.98889586326479 0.00218372390891289 no 3335 0.00139993770633692 4785 6813534
SGTC_3118 9124250 49.47 µM -3.0031974614052 0.00209421535240192 no 3336 0.0013357951397844 4789 1504786
SGTC_3100 9120536 49.47 µM -3.0446201646082 0.00185342775941859 no 3337 0.00116487170081027 4765 16421196
SGTC_299 1273-0059 1.44 µM -3.13183826791462 0.0014267127585319 no 3338 0.000868577705609558 4660 2848077
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -3.22225582168044 0.00108077027441834 no 3339 0.000635927606474861 4790 6708561
SGTC_118 0083-0097 135.343 µM -3.26633957076262 0.000941668606149943 yes 3340 0.000544737600660026 4775 5207356
SGTC_2679 rapamycin 1 nM -3.29686384447943 0.000855203109085836 yes 3341 0.000488854428992553 4713 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_142 0335-0849 62.6745 µM -3.33979274692079 0.000745916488578162 yes 3342 0.000419204667980943 4775 3889043 YPR107C YTH1
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -3.38406978458545 0.000646800284622794 yes 3343 0.00035709924083838 4794 23665772 A membrane-active detergent.
SGTC_1082 camptothecin 424.86 nM -3.40351539709053 0.000607237972557591 yes 3344 0.000332623319243772 4747 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3263 9137018 49.47 µM -3.46076727133471 0.000503365998866858 yes 3345 0.000269319125180541 4796 43844957
SGTC_2075 5212009 200 µM -3.54709481483497 0.000377444359094364 yes 3346 0.000194752192341604 4799 780898
SGTC_2845 9003024 42.97 µM -3.60543231896704 0.000309652869812529 yes 3347 0.00015581685206376 4798 2990173
SGTC_2010 4012422 159 µM -3.61495683505066 0.000299725669146507 yes 3348 0.000150198834230884 4786 952393
SGTC_2074 5212007 75.395 µM -3.88510728864376 0.000115342871951168 yes 3349 5.1142353934105e-05 4802 758611
SGTC_1388 3346-4487 254 µM -3.94084040407902 9.40181186825347e-05 yes 3350 4.0598318478429e-05 4808 3345614
SGTC_58 0957-0393 9 µM -5.51232272052384 1.02750370253374e-07 yes 3351 1.77064409353695e-08 4715 6997992