SGTCid condition conc unit YKL123W|YKL123W.score YKL123W|YKL123W.strain.pval YKL123W|YKL123W.strain.significant YKL123W|YKL123W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3330 9141424 71.43 µM 6.14493433302565 2.25921412751968e-09 yes 1 3.99983014564659e-10 4 27261020
SGTC_278 4092-0821 23.9 µM 4.79565854025648 2.36926105880207e-06 yes 2 8.10706361629323e-07 26 877900
SGTC_1637 st007924 17.4 µM 4.66532165831705 4.26105213835981e-06 yes 3 1.54067322381257e-06 14 683336
SGTC_1142 3253-1408 9.78 µM 4.10331387036467 4.51717259702233e-05 yes 4 2.03637063263457e-05 7 256655
SGTC_2582 agaric acid 100 µM 3.92602069895619 8.98647582802835e-05 yes 5 4.31813634984513e-05 321 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1619 st003326 88.7 µM 3.90585079461942 9.70120394692547e-05 yes 6 4.6947218536109e-05 21 2849032
SGTC_1826 st055655 41.6 µM 3.86238862192506 0.000114267955839688 yes 7 5.61418805233585e-05 42 676168
SGTC_2784 7567673 72.73 µM 3.78601076803986 0.000151758955811564 yes 8 7.6542521792913e-05 35 3471247
SGTC_2108 5365811 200 µM 3.78470686049136 0.000152489213254687 yes 9 7.69449303385447e-05 16 780283
SGTC_182 3448-4371 550.524 µM 3.69294706684758 0.000212988216073423 yes 10 0.000110835088161242 25 3491403
SGTC_2611 pyromycin 23.93 µM 3.68232405478654 0.000221285261666738 yes 11 0.000115558685069801 35 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 3.63566464963049 0.000261428112555382 yes 12 0.000138632416839831 39 5377381
SGTC_3281 9140613 49.47 µM 3.5748264954966 0.000323991447393 yes 13 0.000175230113799064 33 16013766
SGTC_2712 st079126 47.7 µM 3.52181480961943 0.000389586520056758 yes 14 0.000214301719593304 30 3152970
SGTC_3289 9119912 71.43 µM 3.36892539521541 0.0006541614719608 yes 15 0.000377309255829588 33 17014829
SGTC_588 3970-1144 52.9 µM 3.12185951769012 0.00144921426474956 no 16 0.000898563358099378 63 1888707
SGTC_3291 9121177 71.43 µM 3.11135093790267 0.0014973628815968 no 17 0.000931167352555792 42 17015612
SGTC_3110 9122132 49.47 µM 3.09868537106217 0.00155733182645976 no 18 0.000971906629853771 43 918317
SGTC_302 1094-0063 18.9 µM 3.0815644483437 0.00164187739202896 no 19 0.00102957947503264 34 5440289
SGTC_563 tetrahydrosecaminediol 614 µM 3.05409753943738 0.00178628098139213 no 20 0.00112869336577122 45 334274 A psychoactive constituent of the cannabis plant.
SGTC_622 1348-1566 26.3 µM 3.00353987599168 0.00208262987081804 no 21 0.00133429287763753 60 7340407
SGTC_1141 3253-0389 52.6 µM 2.98758302307559 0.00218503054862599 no 22 0.00140596454559625 32 5402031
SGTC_2342 7990637 118.86 µM 2.96462901979992 0.00234034766134509 no 23 0.00151524068410857 93 2033102 YER133W GLC7
SGTC_1685 st024049 53.0905 µM 2.96175867862144 0.00236045704249401 no 24 0.00152943712686255 45 1941139
SGTC_2799 7812892 81.82 µM 2.9577168491977 0.00238903899550749 no 25 0.00154963335032204 71 20205235
SGTC_103 0844-0104 51.839 µM 2.91832388302319 0.0026844547230162 no 26 0.0017595930422782 212 5375804
SGTC_2196 6573537 42.6665 µM 2.91410680593081 0.0027179585929647 no 27 0.00178353921706869 38 2903087
SGTC_1509 1326-1131 80 µM 2.90529521606819 0.00278918629511009 no 28 0.00183453427876817 44 768313
SGTC_2008 4012253 172 µM 2.87776813254266 0.00302267801053465 no 29 0.0020024969556289 87 603940
SGTC_154 3389-1638 511.116 µM 2.87435597629804 0.00305281512105067 no 30 0.00202426184787569 77 5238686
SGTC_169 k015-0017 16.025 µM 2.84348135077621 0.00333805834894048 no 31 0.00223118103890782 60 1840002
SGTC_1783 st039459 87.517 µM 2.82497057447568 0.00352035154324336 no 32 0.00236424791260263 77 729761
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 2.80775703595401 0.0036978393672728 no 33 0.00249439249187112 100 4174840
SGTC_2654 protoveratrine a 100 µM 2.80379192520658 0.00373984398809006 no 34 0.00252527437840747 49 5702278 A heart drug and vasodilator.
SGTC_305 1682-2595 20.8 µM 2.76781910233446 0.00414091632105498 no 35 0.00282163848084736 72 226033
SGTC_1934 st074720 32.6 µM 2.76552776810042 0.00416772115913475 no 36 0.00284153831774882 127 17250992
SGTC_541 4513-1321 94 µM 2.73813471477806 0.00450040617158303 no 37 0.00308943798284911 89 747515
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 2.71895603719065 0.0047472414738437 no 38 0.00327441557641782 92 115019
SGTC_3159 9100096 49.47 µM 2.71251295020315 0.00483283530907539 no 39 0.00333875860705126 89 25236875
SGTC_2160 5660466 132.927 µM 2.68802867854325 0.00517078161309799 no 40 0.00359376116817745 74 2859134
SGTC_175 3793-3120 23.7 µM 2.6859746960363 0.00520006602912965 no 41 0.00361592827244738 86 5322297
SGTC_1925 st057770 10.1 µM 2.68217987787082 0.00525455862649262 no 42 0.00365720593613251 81 5989122
SGTC_2973 9094665 17.96 µM 2.6734830066307 0.00538136382089345 no 43 0.00375340396904638 115 25237061 YIL048W NEO1
SGTC_308 4092-1169 104 µM 2.66817800784036 0.0054600428602402 no 44 0.00381319201154322 135 2268590 YDL196W YDL196W
SGTC_1621 st003705 32.4 µM 2.66475312228666 0.00551137919083053 no 45 0.00385224301151213 109 24207032
SGTC_2596 sinensetin 100 µM 2.6390382312202 0.00591071920631752 no 46 0.00415708020672152 105 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_920 mycophenolic acid 780.421 nM 2.6331858193873 0.00600511232318499 no 47 0.00422940274303692 116 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1207 2099-0101 141 µM 2.6141859614966 0.00632083615089319 no 48 0.00447201703734428 95 5837381
SGTC_53 0973-0023 39.979 µM 2.59090281656999 0.00672771049622837 no 49 0.00478622598385165 88 674768
SGTC_2515 chrysin 20.77 µM 2.58295116811868 0.00687187549859525 no 50 0.00489795934955029 78 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_602 3130-1533 38.1 µM 2.56490581981097 0.00720920448502551 no 51 0.00516019068119176 113 720941
SGTC_2101 5377231 179.231 µM 2.55531857491539 0.00739429662134954 no 52 0.0053045325166455 73 2844213
SGTC_2069 5228469 200 µM 2.55176230275254 0.00746401178818536 no 53 0.00535898062563523 94 2835210
SGTC_2846 9008642 19.48 µM 2.54416589591416 0.00761486998247395 no 54 0.00547695232693793 89 2992898
SGTC_1715 st032160 10.2275 µM 2.51814793476056 0.00815210200989762 no 55 0.00589868797203846 137 5289825
SGTC_2447 5741742 33.78 µM 2.51005638385709 0.00832583596450817 no 56 0.00603559428515855 127 1776504
SGTC_94 0334-0113 514.748 µM 2.49459094359559 0.00866695906539404 no 57 0.00630512037552588 129 6795178
SGTC_1295 1013-0063 9.78 µM 2.49393108033713 0.00868178252575741 no 58 0.00631685360794222 109 6826038
SGTC_2968 9090663 33.37 µM 2.48660463338008 0.0088478668133523 no 59 0.00644843190004308 139 25236811
SGTC_530 4358-1714 28 µM 2.47777857766626 0.00905163847717964 no 60 0.0066101579959323 160 1564641
SGTC_1236 0330-0013 258 µM 2.47244853868178 0.00917667627362095 no 61 0.00670955160367007 97 4617066
SGTC_39 0986-0283 58.349 µM 2.45762789550272 0.00953233496082124 no 62 0.00699290008341586 151 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_571 k831-0106 44.2 µM 2.452019689131 0.00967002810272164 no 63 0.00710284443635842 113 4783639
SGTC_1780 st038448 24.544 µM 2.45187641720171 0.00967356837791272 no 64 0.00710567303460963 127 728868 YDL195W SEC31
SGTC_2298 7976326 193.81 µM 2.442481276174 0.00990821015803339 no 65 0.00729334312503926 81 2235818
SGTC_3256 9138902 49.47 µM 2.42079153040941 0.0104689696145661 no 66 0.00774337789536374 38 17228773
SGTC_570 0987-0065 62.6 µM 2.41726259196681 0.0105627746550241 no 67 0.00781886564624741 71 3104428
SGTC_670 4204-0025 119 µM 2.39281876455268 0.0112328636649505 no 68 0.00835974878229713 147 719039
SGTC_1527 coumarin 137 µM 2.38645445445021 0.0114132809383286 no 69 0.00850585720531551 128 323 A hepatotoxic, DNA x-linker.
SGTC_1414 3917-0015 5.4 µM 2.38208249080405 0.0115386725947744 no 70 0.00860752033091189 103 6618702
SGTC_1039 k821-0043 94 µM 2.3818848618508 0.0115443689155499 no 71 0.00861214095442895 138 15992768
SGTC_101 0490-5701 117.494 µM 2.38127556836759 0.011561946144553 no 72 0.0086264001134735 101 4661669
SGTC_1649 st011737 51.3 µM 2.37774781976605 0.0116641740576826 no 73 0.00870936696009418 102 1761035
SGTC_38 0929-0051 58.268 µM 2.37610754734913 0.0117119728815445 no 74 0.00874818119260001 146 1379719
SGTC_634 1611-4317 11.2 µM 2.36435644828968 0.0120594076613186 no 75 0.00903071274305411 136 2843522
SGTC_659 k018-0002 107 µM 2.36267997425866 0.0121096958550215 no 76 0.00907166475382445 130 6797879 YHR007C ERG11
SGTC_806 3966-4455 5.86 µM 2.35545892995623 0.0123283845743853 no 77 0.009249920965544 123 714982
SGTC_2713 st079149 53.4 µM 2.35265334833857 0.0124142696924718 no 78 0.00932000107089737 150 3103253
SGTC_3272 9137413 49.47 µM 2.35001215474804 0.0124955955734747 no 79 0.00938639901810711 124 17614870
SGTC_2951 9072950 58.06 µM 2.34682024689408 0.0125944939446252 no 80 0.00946719345781769 150 16488155
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.3331696302061 0.0130251283402761 no 81 0.00981962205380879 169 23847180
SGTC_2175 5807670 165.306 µM 2.32360348498263 0.0133344437096216 no 82 0.0100733777427998 133 241186
SGTC_164 4100-3994 89.624 µM 2.31212591543352 0.0137139180743797 no 83 0.010385372697972 187 4615967
SGTC_2116 5511452 16.8835 µM 2.30114132668288 0.0140857820722957 no 84 0.0106918220220387 140 870744
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.29967129201037 0.0141362008779337 no 85 0.0107334248658359 183 442882
SGTC_3248 9135562 49.47 µM 2.27994294402417 0.0148280298430861 no 86 0.0113055363198853 120 17650701
SGTC_907 3448-6986 75.5 µM 2.27339862033511 0.0150638663483032 no 87 0.0115010846080285 179 590582
SGTC_1510 1123-0200 71.5 µM 2.26820625946915 0.0152532690464098 no 88 0.0116583190630868 204 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2803 7707263 71.43 µM 2.26781350138124 0.0152676786058948 no 89 0.0116702880748239 166 2199229
SGTC_393 acivicin 6.25 µM 2.26436525005309 0.0153946911938741 no 90 0.0117758297084135 121 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 2.26427384559224 0.0153980702837153 no 91 0.0117786385839659 156 688662
SGTC_1758 st042942 75.2445 µM 2.26279447075158 0.0154528492426811 no 92 0.0118241809617689 143 669317
SGTC_376 3970-0862 59.1 µM 2.26162146622615 0.0154964026174367 no 93 0.0118604002920925 166 3135186
SGTC_3008 9078912 71.4286 µM 2.25904787114229 0.0155923289045004 no 94 0.0119402036241973 140 16648731
SGTC_1919 st067113 52.3 µM 2.24443688507467 0.0161466406842895 no 95 0.0124021527641756 192 1268243
SGTC_2081 5214970 32.255 µM 2.23919938675145 0.0163494108457392 no 96 0.012571472869033 155 2063512
SGTC_1557 sumaresinolic acid 42.3 µM 2.23887913970841 0.0163618796677966 no 97 0.0125818905637999 163 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1129 3453-1384 223 µM 2.23056324614492 0.0166885220243134 no 98 0.0128550368285124 200 1084452
SGTC_2923 7992654 58.14 µM 2.21408360288001 0.0173523377768064 no 99 0.0134115141904453 176 2985126
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 2.20999366072457 0.017520534968821 no 100 0.0135528011267708 228 688788
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.20544692355409 0.0177091494299867 no 101 0.0137113741987296 151 689007
SGTC_1836 st055642 81 µM 2.19007326374321 0.0183597875310982 no 102 0.0142594619435369 191 8571
SGTC_1963 st076565 50.3 µM 2.18246040756441 0.018689443783752 no 103 0.0145377851232489 137 4914280
SGTC_2087 5276107 200 µM 2.17270539600385 0.0191192130894416 no 104 0.014901248701398 157 144405
SGTC_217 ketoconazole 989 nM 2.16945112405586 0.0192644406504074 no 105 0.0150242256044411 173 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1922 5578187 25 µM 2.16525980489812 0.0194528660148931 no 106 0.0151838973498477 203 1350412
SGTC_1612 st002233 45.4 µM 2.1601742063988 0.0196835948602477 no 107 0.0153795930704264 161 1035021
SGTC_1123 mangostin 811.285 nM 2.14197854378796 0.0205282341740494 no 108 0.0160976043242411 226 5281650 An antioxidant.
SGTC_3274 9138298 49.47 µM 2.13845651276442 0.0206952248095834 no 109 0.0162398550081493 172 17015756
SGTC_2764 methyldopa 94.69 µM 2.13723014521975 0.020753640164429 no 110 0.016289638652539 194 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3153 9100258 49.47 µM 2.11689351154803 0.0217428697285707 no 111 0.0171344432378875 209 25236848
SGTC_1861 st057647 17.4 µM 2.1075523615692 0.0222104302074373 no 112 0.0175348639731697 192 688668
SGTC_2043 5101342 149 µM 2.10591448871876 0.0222932801045146 no 113 0.0176058904432308 195 678451
SGTC_2198 6589944 200 µM 2.10573234177886 0.0223025098853864 no 114 0.0176138044093895 141 5290268
SGTC_1792 st045773 43.6 µM 2.09937452833069 0.0226267000480685 no 115 0.01789194912952 209 2919270
SGTC_335 4077-0256 27.6 µM 2.09586616554363 0.0228072890604423 no 116 0.0180470324332216 202 3121989
SGTC_316 k060-0003 58.6 µM 2.0958623696254 0.0228074851068545 no 117 0.0180472008462679 173 6152314
SGTC_2546 rhodinyl acetate 100 µM 2.09231890910227 0.0229911133209573 no 118 0.0182049986535004 180 6708682
SGTC_389 tpck 16.7 µM 2.08789078617933 0.0232223351411735 no 119 0.0184038437546971 203 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_779 1360-0071 233 µM 2.08747717698219 0.0232440320478357 no 120 0.0184225110083452 218 7566
SGTC_1020 4335-0961 93.3 µM 2.08660186429998 0.0232900050393778 no 121 0.0184620693176038 179 669075
SGTC_1579 chlormadinone acetate 49.4 µM 2.08472009476072 0.0233890981105785 no 122 0.0185473577605115 183 45114258 A steroidal progestin.
SGTC_1702 st027038 51 µM 2.07929994209698 0.0236765053580221 no 123 0.0187948952272178 198 5521182
SGTC_1402 3909-7673 35.9 µM 2.0707002942346 0.0241385987784154 no 124 0.0191934063632473 197 5328014
SGTC_1132 3456-3614 2.5 µM 2.06911148896495 0.0242247954758615 no 125 0.0192678129315999 274 3125502
SGTC_3335 9143315 29.6265 µM 2.06477986813181 0.0244611109060242 no 126 0.0194719167714665 180 4899691
SGTC_1760 st045453 10.4495 µM 2.06212912350831 0.0246066768142855 no 127 0.0195977221454643 311 3323419 YIL048W NEO1
SGTC_671 0560-0003 407 µM 2.05287750244285 0.0251204383517321 no 128 0.0200422297317839 177 3238678
SGTC_2543 pimpinellin 60.67 µM 2.0381131677054 0.0259589394168518 no 129 0.0207693082972103 207 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2475 5812728 15.03 µM 2.02148952143899 0.0269309302376131 no 130 0.0216145579893619 229 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.01744385792467 0.0271720243649673 no 131 0.021824607141254 307 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1653 st012112 65 µM 2.01381612606378 0.0273897413871641 no 132 0.0220144210024809 185 720429
SGTC_686 1319-0111 510 µM 2.01313892003376 0.027430544368985 no 133 0.0220500083871493 215 4562600
SGTC_1044 1222-0021 1.78 µM 2.00200966153252 0.0281083969595338 no 134 0.0226418462160866 242 4306703
SGTC_293 4049-0273 38.5 µM 2.00149841653936 0.0281398676102743 no 135 0.0226693521235132 179 1380311
SGTC_3305 9127027 53.8275 µM 1.99677405483057 0.0284320750184006 no 136 0.0229248666215526 225 41905295
SGTC_2035 5154463 94.595 µM 1.99552129326223 0.028509981930818 no 137 0.0229930270754519 249 2769623
SGTC_781 4335-2806 94.4 µM 1.99508650585248 0.0285370620300517 no 138 0.0230167229239256 235 845254
SGTC_458 nppb 133 µM 1.9888396529446 0.0289285059497196 no 139 0.0233594522225874 177 4549 A chloride channel blocker.
SGTC_1418 3966-3099 2.4 µM 1.98396212123818 0.0292372383120139 no 140 0.0236300313877333 238 740335
SGTC_2961 9083290 32.55 µM 1.97569123502951 0.0297670122012244 no 141 0.0240948791192492 200 17741490
SGTC_3135 9127742 49.47 µM 1.96496248609365 0.0304660613412836 no 142 0.0247092897934185 188 3643468
SGTC_1791 st048313 56.1 µM 1.96176299977754 0.0306771427325439 no 143 0.0248950416361353 187 1204976
SGTC_3035 9091303 49.47 µM 1.958858270285 0.0308698253980834 no 144 0.0250646936090306 151 25237002
SGTC_12 0849-0099 9.267 µM 1.95833030458568 0.0309049548983821 no 145 0.0250956335218226 207 6071388
SGTC_3293 9120939 62.045 µM 1.95784315455489 0.0309373979708275 no 146 0.0251242099395199 217 934087
SGTC_1815 st051655 58.2 µM 1.95368370632911 0.0312155570179312 no 147 0.0253693171997924 173 5984156
SGTC_1213 1315-0166 115 µM 1.92372896412186 0.0332804128160679 no 148 0.0271942827614483 214 768401
SGTC_271 rotenone 740 µM 1.92198820499351 0.0334037870754528 no 149 0.0273036209599248 274 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1950 st077106 7.18 µM 1.92055481660678 0.0335056592883827 no 150 0.027393928053204 261 13831864
SGTC_309 k408-0051 1.48 µM 1.91411293584638 0.033966651909495 no 151 0.0278028635023831 337 3640463
SGTC_2663 amphotericin b 100 µM 1.91171815180183 0.0341393516270149 no 152 0.0279561774094628 228 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2588 indole-3-carbinol 100 µM 1.91122945996596 0.0341746821520511 no 153 0.0279875497784278 310 3712 Induces cell cycle arrest.
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.90854645827384 0.0343691886718117 no 154 0.0281603122637276 277 1273210
SGTC_1433 4060-0023 7.6 µM 1.90736531880858 0.034455104327727 no 155 0.0282366485717621 232 3840627
SGTC_828 2074-0507 139 µM 1.90496872000808 0.0346299743539902 no 156 0.0283920686431102 268 X828
SGTC_610 4215-0184 155 µM 1.90241150523209 0.0348173670591586 no 157 0.0285586890356422 260 5605015
SGTC_1895 st058434 18.3 µM 1.90167201332715 0.034871711951848 no 158 0.0286070234314067 242 5393175
SGTC_745 0469-0705 296 µM 1.89544312411959 0.0353322388342617 no 159 0.0290168600360417 284 3486736
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.89011167294863 0.0357303656193338 no 160 0.0293715131365721 251 4330530
SGTC_1411 3909-8223 150 µM 1.8897561252387 0.0357570464297636 no 161 0.0293952919705005 238 X1411
SGTC_249 wiskostatin 11.211 µM 1.88800862689939 0.0358884186308917 no 162 0.0295123961547221 215 2775510 A n-wasp and actin depolymerizer.
SGTC_2837 9008476 45.46 µM 1.88660807005841 0.0359939939372712 no 163 0.0296065302635479 288 2992805
SGTC_2864 9034755 47.6 µM 1.87674791334577 0.0367444818809053 no 164 0.0302763261829105 254 4930451
SGTC_2033 5192550 145 µM 1.87475280884327 0.0368978817059589 no 165 0.0304133690651731 231 182073
SGTC_2393 9031399 185.94 µM 1.87459165144342 0.0369102956163928 no 166 0.0304244612968073 278 1526623 YDL150W RPC53
SGTC_874 0599-0792 117 µM 1.8715194904603 0.0371475970327656 no 167 0.0306365554645539 298 765305
SGTC_2647 atorvastatin 60.16 µM 1.86978886475822 0.037281822951709 no 168 0.0307565716427743 242 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1966 st070145 16.1 µM 1.86968725205193 0.0372897162497947 no 169 0.0307636304059856 253 3748532
SGTC_1293 1000-1278 195 µM 1.86968465284947 0.0372899181743382 no 170 0.0307638109832268 262 678847
SGTC_130 0136-0219 337.655 µM 1.85581744429167 0.0383800059477631 no 171 0.0317397916299784 268 234244
SGTC_133 0724-0033 378.92 µM 1.85273678971369 0.0386256663576596 no 172 0.0319600470771739 239 280309
SGTC_699 0375-0592 111 µM 1.84872358810526 0.0389476108899146 no 173 0.0322488679232311 239 762578
SGTC_381 3461-2219 42.7 µM 1.83355578578966 0.0401841816880633 no 174 0.0333599802544829 283 2883159
SGTC_280 3448-3607 3.04 µM 1.83175893427398 0.0403327617676274 no 175 0.0334936719726549 226 626179
SGTC_2943 9068529 45.32 µM 1.83063634509258 0.0404258139061763 no 176 0.0335774199699849 285 3270634
SGTC_1928 4'-methoxychalcone 40.3 µM 1.82584163226554 0.0408252147716612 no 177 0.0339370601048713 231 641818
SGTC_1717 st033143 58.0435 µM 1.8253279720879 0.0408681920108854 no 178 0.0339757757378446 313 674616
SGTC_2812 7970281 58.44 µM 1.82389493662713 0.0409882861774889 no 179 0.0340839786585645 315 2233435
SGTC_2473 5854593 8.94 µM 1.82248714186563 0.0411065436293407 no 180 0.0341905514922766 228 2872951
SGTC_3106 9121286 49.47 µM 1.82226296778846 0.0411254001910946 no 181 0.0342075471678171 250 15943471
SGTC_1171 0368-0077 21.4 µM 1.82100365775126 0.0412314583573511 no 182 0.0343031504275712 248 3239779
SGTC_3142 9086498 49.47 µM 1.81725542597019 0.0415484444237256 no 183 0.0345890058469252 271 25236367
SGTC_992 3909-8734 162 µM 1.81660545857495 0.0416036121923898 no 184 0.0346387735176875 264 4288319
SGTC_1428 4049-0204 61.7 µM 1.81619100494396 0.0416388210567467 no 185 0.0346705387165796 273 X1428
SGTC_2539 epi(13)torulosol 80 µM 1.81480328246043 0.0417568872742777 no 186 0.0347770728987381 286 6708597
SGTC_2558 carylophyllene oxide 100 µM 1.81264299354323 0.0419412221829592 no 187 0.0349434510722603 278 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1837 st055472 66.5 µM 1.81147315439491 0.0420413178188029 no 188 0.0350338204893438 287 676091
SGTC_740 k014-0057 261 µM 1.80336273110435 0.0427406031118572 no 189 0.035665633328045 321 4012779
SGTC_2556 citropten 84.59 µM 1.79928374412333 0.043095832682787 no 190 0.0359869040914892 327 2775 A potential DNA crosslinker.
SGTC_1570 verbenone 133 µM 1.79822868444418 0.0431881025823077 no 191 0.0360703878599692 273 29025 A natural terpanoid with antifungal properties.
SGTC_813 k007-0158 173 µM 1.79716402843256 0.0432813733994691 no 192 0.0361547916671538 348 6523916
SGTC_1507 4075-3230 155 µM 1.7943331145816 0.0435301713835344 no 193 0.0363800078148908 222 659771
SGTC_1757 st041620 31.8375 µM 1.79335523483002 0.0436163811911186 no 194 0.0364580703160461 291 5289815
SGTC_1400 3771-8998 51.5 µM 1.78909262511879 0.0439937831552673 no 195 0.0367999498431562 228 670767
SGTC_2716 st080858 38.6235 µM 1.77729778250477 0.0450518109807581 no 196 0.0377596291591773 252 5296050
SGTC_3103 9120822 49.47 µM 1.77613564598845 0.0451571566008361 no 197 0.0378552810880148 284 17141819
SGTC_2278 7948257 134.34 µM 1.77324896076571 0.0454196872928185 no 198 0.0380937311651815 277 1247028
SGTC_392 N-ethylmaleimide 8.33 µM 1.77122159010803 0.0456048000271049 no 199 0.038261930179549 266 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_359 0081-0058 15.9 µM 1.76933950889432 0.0457771892959202 no 200 0.0384186169377838 310 3494159
SGTC_3298 9116858 71.43 µM 1.76857729186008 0.0458471534151794 no 201 0.0384822215472857 274 2506942
SGTC_1610 st001799 48.1 µM 1.76139296617926 0.0465108349222985 no 202 0.0390859573599467 235 621897
SGTC_1781 st038725 66.3 µM 1.760285659516 0.0466138093541481 no 203 0.0391796922001748 406 4270275 YIL048W NEO1
SGTC_3247 9135149 49.47 µM 1.75327866811727 0.0472696758279049 no 204 0.039777092644818 249 8934436 YOR116C RPO31
SGTC_102 gallobenzophenone 83.616 µM 1.7398969096724 0.0485427690254164 no 205 0.040938560716286 337 70837
SGTC_967 1306-0166 352 µM 1.73881027094976 0.0486473400992854 no 206 0.0410340706805964 326 4437607
SGTC_263 alizarin 107.927 µM 1.73369409935354 0.0491421094977809 no 207 0.0414861870232472 407 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2658 polymyxin b sulfate 77.05 µM 1.72834610097672 0.0496635860629855 no 208 0.0419630962569686 321 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_161 4065-0411 162.148 µM 1.71764695105688 0.0507200945788605 no 209 0.0429305154626096 399 1906281 YLR208W SEC13
SGTC_326 k292-0812 17.5 µM 1.71572434372836 0.0509118297750785 no 210 0.043106253504529 255 3579357
SGTC_2657 nystatin 74.44 µM 1.71245569297291 0.0512391253224582 no 211 0.0434063615615294 311 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2097 5376186 200 µM 1.7077404984312 0.0517142124764621 no 212 0.04384225201378 337 742755
SGTC_2505 galangin 7.89 µM 1.70740047594572 0.051748606909874 no 213 0.0438738209858235 237 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2276 7947513 42.08 µM 1.70311114021699 0.0521840510562039 no 214 0.0442736357706885 296 2105100
SGTC_2436 5633522 8.09 µM 1.70038013452103 0.052462809809679 no 215 0.0445297230076916 348 5724242
SGTC_2360 9040895 200 µM 1.69471619322327 0.0530447060257418 no 216 0.0450646361424969 315 4914414
SGTC_1296 1068-0102 11.9 µM 1.67963361011716 0.054619223065952 no 217 0.0465143120742664 329 767053
SGTC_473 2-arachidonoylglycerol 10 µM 1.67335225133473 0.0552857566978528 no 218 0.0471289859063113 327 5282280 An endocannabinoid.
SGTC_1654 st012436 41.8 µM 1.67322366301495 0.0552994683869661 no 219 0.0471416368416968 292 4323132
SGTC_469 w7 172 µM 1.66921891385985 0.0557278504974686 no 220 0.047537001526684 231 45115570 A P450 inhibitor.
SGTC_1138 3761-0006 1.03 µM 1.66659577209237 0.0560098606098933 no 221 0.0477974050788794 277 12061087
SGTC_564 3555-0129 330 µM 1.66444201761306 0.0562422480725151 no 222 0.0480120645855182 244 563260
SGTC_645 0845-0943 5.41 µM 1.66106858397225 0.0566077644383546 no 223 0.048349836580764 322 1885106
SGTC_1795 st049545 62.3 µM 1.65497627518936 0.0572726143606174 no 224 0.0489646552530657 322 5291882
SGTC_3338 9144300 39.5675 µM 1.65435923427808 0.057340292941509 no 225 0.0490272720856807 344 4901274
SGTC_612 0302-0167 22.4 µM 1.65303743577306 0.0574854828638523 no 226 0.0491616224562722 417 235821
SGTC_735 3076-0345 636 µM 1.6516766054914 0.0576352621133316 no 227 0.0493002471217 388 2888990
SGTC_531 3788-1495 174 µM 1.64573774553649 0.0582925156387612 no 228 0.0499088821453718 348 2896655
SGTC_2975 9084847 53.72 µM 1.64509899163021 0.058363555782699 no 229 0.0499746992628801 368 27211724
SGTC_565 1418-0001 44.5 µM 1.63377446558011 0.059634354838921 no 230 0.0511531078960702 401 2862145
SGTC_1752 st044819 83.042 µM 1.63237429352729 0.0597929720911353 no 231 0.0513003305423258 358 441209 YML126C ERG13
SGTC_1283 0922-0125 16.4 µM 1.62923049748639 0.060150318321991 no 232 0.0516321165488918 380 3360884
SGTC_2915 7971052 15.16 µM 1.62870078736446 0.060210693200986 no 233 0.0516881880045473 236 5741558
SGTC_1302 1159-0335 255 µM 1.62408351580568 0.0607389677763925 no 234 0.0521789927839332 339 649284
SGTC_2295 7971645 200 µM 1.61984789629923 0.0612267579264309 no 235 0.0526324773286313 375 2978226 YKL099C UTP11
SGTC_445 e6 berbamine 66 µM 1.61564855142517 0.0617133870798953 no 236 0.0530851601953417 512 6610268 A calcium/calmodulin antagonist.
SGTC_1957 st077035 62.4 µM 1.61468426341643 0.0618255560317463 no 237 0.0531895435559438 334 705593
SGTC_814 3342-0569 96 µM 1.60984191764878 0.0623912403904847 no 238 0.0537161857861373 402 4346283
SGTC_2926 9010726 65.15 µM 1.60615147816071 0.0628250624571805 no 239 0.0541203157458843 384 2994293
SGTC_446 go6976 132 µM 1.60610336609586 0.0628307336537228 no 240 0.0541256002130445 320 3501 A protein kinase C inhibitor.
SGTC_2163 5671233 125 µM 1.60564227474225 0.0628851049032616 no 241 0.0541762656474261 392 701023
SGTC_552 k242-0005 476 µM 1.60354597195649 0.0631327603049863 no 242 0.054407084011532 320 4088318
SGTC_866 0495-0101 262 µM 1.60105490557062 0.0634280395446861 no 243 0.0546823794077478 323 635694
SGTC_942 3253-1115 227 µM 1.5949305154554 0.0641585658034455 no 244 0.0553638874151825 365 46497897
SGTC_3234 9132280 49.47 µM 1.59441419611172 0.0642204508500885 no 245 0.0554216474432168 397 17612295
SGTC_733 4069-0007 56.1 µM 1.59322079998263 0.064363666569201 no 246 0.0555553333221723 464 5717425 YNL287W SEC21
SGTC_459 nigericin 15.3 µM 1.58845324668408 0.0649382830015997 no 247 0.056091942593681 417 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2288 7946289 167.31 µM 1.58376097694644 0.0655077064012598 no 248 0.0566240613386168 439 1246052
SGTC_687 k029-0044 34.9 µM 1.5823326652351 0.0656818035784201 no 249 0.0567868237242281 389 5829338
SGTC_234 nsc-17383 10.7 µM 1.58148578640098 0.0657851990628467 no 250 0.0568835031623189 439 408974
SGTC_3057 9095946 49.47 µM 1.57851999801914 0.0661482870870907 no 251 0.0572230988029845 351 24540043
SGTC_1709 st033179 39.1045 µM 1.57630745315235 0.0664201684783999 no 252 0.0574774824108692 404 573381
SGTC_759 3486-0358 89.3 µM 1.57435542023555 0.0666607553887118 no 253 0.0577026519811977 411 875103
SGTC_808 0711-0032 135 µM 1.57348846386476 0.066767823298811 no 254 0.0578028787219383 365 4252555
SGTC_2600 tangeritin 87.95 µM 1.57198387879609 0.0669539532626125 no 255 0.0579771450083006 365 68077 A bioactive flavone.
SGTC_3245 9134821 49.47 µM 1.5712971275882 0.0670390435208772 no 256 0.058056824054583 408 17014901
SGTC_2903 5923464 63.88 µM 1.56481583981767 0.0678462163348717 no 257 0.0588130482989286 330 2876576
SGTC_3210 9128157 49.47 µM 1.561952298282 0.0682052206964213 no 258 0.0591496133757012 404 17590849
SGTC_2347 9049783 174.81 µM 1.55496369326145 0.0690875422317517 no 259 0.0599773582297008 433 6467988 YPL169C MEX67
SGTC_777 1315-0167 517 µM 1.55357216974858 0.0692642695422024 no 260 0.0601432510066868 369 4221767
SGTC_842 0271-0008 11.1 µM 1.54450424737693 0.0704244618533102 no 261 0.061233111551838 424 1221709
SGTC_1235 benzylparaben 21.5 µM 1.54328526362747 0.0705815569287555 no 262 0.0613807887565806 377 7180
SGTC_829 1635-0120 117 µM 1.53987053820624 0.0710230597076051 no 263 0.0617959567693229 445 285054
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.53983239258274 0.0710280036515434 no 264 0.0618006069274839 395 803109
SGTC_1552 6-methylflavone 10.6 µM 1.53918274171534 0.0711122436094563 no 265 0.0618798448344586 332 689013
SGTC_1158 4092-0494 91.8 µM 1.53863023571475 0.071183947184572 no 266 0.0619472963591944 415 1148199
SGTC_2143 5623677 140.463 µM 1.53539362255191 0.0716051065948273 no 267 0.0623435846558624 329 5375313
SGTC_516 3992-2719 87.3 µM 1.53518277777771 0.071632608639549 no 268 0.06236946875212 352 5350887 YDR037W KRS1
SGTC_3287 9117173 37.0625 µM 1.53114817668714 0.0721604340864112 no 269 0.0628663876880697 314 2789709
SGTC_1275 0867-0008 21.1 µM 1.52997369317986 0.0723146443903979 no 270 0.0630116203349449 416 3422836
SGTC_1744 st037937 38.9 µM 1.52988890087927 0.0723257874306987 no 271 0.0630221155697296 398 1016152
SGTC_1855 st056195 39.6 µM 1.52904282248963 0.0724370474975524 no 272 0.0631269141903921 404 4028379
SGTC_2922 7999257 32.47 µM 1.52750505462968 0.0726396010253217 no 273 0.0633177356424975 356 2988377
SGTC_970 1315-0089 19.5 µM 1.52640303964539 0.0727850241504951 no 274 0.0634547605601717 382 6811083 YLR033W RSC58
SGTC_3072 9116419 49.47 µM 1.52362174959422 0.0731530374481254 no 275 0.0638016134142741 356 17170162
SGTC_213 1246-0773 967 nM 1.52360754414262 0.0731549207254622 no 276 0.0638033887445511 432 6251622
SGTC_812 4251-0442 148 µM 1.51953758635193 0.0736960218223087 no 277 0.0643136172862954 377 5723007
SGTC_722 3534-0461 190 µM 1.51206864774935 0.0746969694818159 no 278 0.0652581998687515 428 658262
SGTC_2445 5742597 35.57 µM 1.51129585723015 0.0748011241817439 no 279 0.0653565444943074 395 1774255
SGTC_1322 1348-1070 12 µM 1.50980926080831 0.0750017953336569 no 280 0.0655460506624176 345 6758089
SGTC_522 1273-0010 11.6 µM 1.50238441127389 0.0760102046326106 no 281 0.0664989299587666 406 5705015
SGTC_881 0833-0569 170 µM 1.49823271394297 0.0765785512807919 no 282 0.0670363994504288 441 5418700
SGTC_1464 k208-0027 110 µM 1.49625130441757 0.0768509331864776 no 283 0.0672940897835538 437 X1464
SGTC_2361 9034121 116 µM 1.49604719273777 0.0768790339582446 no 284 0.067320678780352 405 6496917
SGTC_2720 fluspirilene 36.88 µM 1.49537361514447 0.0769718231744135 no 285 0.0674084812722906 349 3396 An atypical antipsychotic.
SGTC_3088 9117578 49.47 µM 1.49512698486737 0.0770058192059181 no 286 0.0674406522618616 382 678341
SGTC_568 1193-0097 7.48 µM 1.49425126075443 0.0771266230481028 no 287 0.0675549794971115 496 3646150
SGTC_1655 st012546 55.1 µM 1.49331937001852 0.0772553330289578 no 288 0.0676768037917538 390 720985 YLR208W SEC13
SGTC_895 0964-0006 13.7 µM 1.49050841479446 0.0776445623209133 no 289 0.0680453027855691 413 6738897
SGTC_3353 9151644 39.2805 µM 1.48701977504612 0.0781296979837564 no 290 0.068504794082259 434 4909158
SGTC_2058 5236698 133 µM 1.48599920510823 0.0782720538430038 no 291 0.0686396656263378 433 766665
SGTC_1879 gemcitabine 100 µM 1.47446658693144 0.0798943966473507 no 292 0.0701780038186164 424 60750 A nucleoside analog which inhibits DNA replication.
SGTC_861 0443-0273 110 µM 1.46751400982545 0.0808846576969175 no 293 0.0711181404886048 422 6149169
SGTC_769 0302-0231 76 µM 1.46582815824472 0.0811261648545326 no 294 0.07134755390163 546 571869 YER009W NTF2
SGTC_3193 9111931 49.47 µM 1.4654226402902 0.0811843385529157 no 295 0.0714028221028081 438 17087244
SGTC_1120 ficusin 1.78878 µM 1.46435992291136 0.0813369403113461 no 296 0.071547816160332 434 6199 A DNA cross-linker.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.46242324889983 0.0816155948900512 no 297 0.0718126311770291 422 6708514
SGTC_2477 5967686 25.23 µM 1.46066144960118 0.0818697126365153 no 298 0.0720541867322584 452 776118
SGTC_60 0986-0278 202 µM 1.45831798565768 0.0822086518152417 no 299 0.0723764574849035 320 3110598
SGTC_373 0844-0104 25.9 µM 1.45392344851142 0.0828470887670627 no 300 0.0729837654921173 463 5375804
SGTC_2643 anethole 100 µM 1.44717721500146 0.0838344279112436 no 301 0.0739236481708637 470 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3063 1327-0034 4 µM 1.44157060523288 0.0846616813436348 no 302 0.0747117729211465 438 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3263 9137018 49.47 µM 1.4405432136909 0.0848139341074724 no 303 0.0748568865948034 454 43844957
SGTC_2007 4011539 71.82 µM 1.43988470911629 0.0849116281212625 no 304 0.0749500099325709 483 45595301
SGTC_1645 Cervolide 78 µM 1.43808055922885 0.0851797192321822 no 305 0.0752055989834405 420 23173 A fragrance.
SGTC_479 n-linoleoylglycine 10 µM 1.43595349859082 0.085496607992259 no 306 0.0755077868867815 408 6433346 An anti-infammatory.
SGTC_917 harmaline 728.087 nM 1.4328694614738 0.0859576336891534 no 307 0.0759475730028306 465 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1323 1348-1351 11.2 µM 1.43140107475847 0.0861777921095191 no 308 0.0761576502806553 428 6989654
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.4269307454155 0.0868506349226923 no 309 0.0767999288376513 476 5393153
SGTC_1211 1056-0033 32.3 µM 1.42427464811963 0.0872522667027958 no 310 0.0771834916475687 470 6741922
SGTC_2581 avocatin a 64 µM 1.42381992541863 0.0873211646901273 no 311 0.0772493031033361 506 6710728 A skin care supplement.
SGTC_3311 9131146 2.8755 µM 1.42352380991513 0.0873660529026372 no 312 0.0772921824495549 498 4900406 YPR165W RHO1
SGTC_3304 9125678 46.087 µM 1.41629566004569 0.0884671182610251 no 313 0.0783444789910935 497 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2880 9042983 58.44 µM 1.4155441364797 0.0885821886942526 no 314 0.0784545085974858 476 6464714
SGTC_3058 9093861 49.47 µM 1.41489046534155 0.0886823669661203 no 315 0.078550306985512 474 17217477
SGTC_1310 1188-0297 994 nM 1.41395335896775 0.0888261302171096 no 316 0.0786877986966065 480 1588352
SGTC_2312 7706453 155.7 µM 1.41007553760184 0.0894228791484287 no 317 0.079258689788748 475 976098
SGTC_1156 4092-0367 4.88 µM 1.40498467537375 0.0902108205317438 no 318 0.0800129176439943 495 1357585
SGTC_2218 6965428 192.983 µM 1.40447055605503 0.0902906794817698 no 319 0.080089386765312 474 675684
SGTC_372 0155-0182 15.9 µM 1.40446879703269 0.0902909528035333 no 320 0.0800896484937254 505 771486
SGTC_2852 9023854 51.95 µM 1.40261059784811 0.0905800282533395 no 321 0.0803664949055817 496 19798528
SGTC_2257 7960413 200 µM 1.39930636286108 0.0910957559773842 no 322 0.0808605661997686 546 2974689 YIL048W NEO1
SGTC_3356 9151811 4.48 µM 1.3957956097193 0.0916461000079765 no 323 0.0813880264146091 479 1859254 YPR165W RHO1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.39452201795607 0.0918463554077701 no 324 0.081580012677227 516 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.39211548530155 0.0922256352277047 no 325 0.0819437148696485 411 17037758
SGTC_809 3998-0021 90 µM 1.39167331096445 0.0922954496875974 no 326 0.0820106738835087 446 715485
SGTC_2189 6047310 154.431 µM 1.38275373054187 0.0937121170363751 no 327 0.08337019533316 458 711535
SGTC_3204 9114183 49.47 µM 1.38205677888354 0.0938234840820505 no 328 0.0834771339924794 486 17027248
SGTC_1844 rapamycin 4 nM 1.3797250897074 0.0941967786341637 no 329 0.0838356524120292 640 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3050 9093513 49.47 µM 1.37764568971175 0.0945306058426209 no 330 0.0841563535306115 476 25236664
SGTC_856 0433-0016 11.3 µM 1.37755473329977 0.0945452278842146 no 331 0.0841704025232983 524 3911780
SGTC_198 3454-2873 16.191 µM 1.37752643149966 0.0945497779871128 no 332 0.084174774336526 481 710957
SGTC_1000 4048-0884 8.67 µM 1.37550500082139 0.0948751826807601 no 333 0.08448746820533 501 13040088
SGTC_360 0957-0399 1.01 µM 1.37204140023844 0.0954346611080201 no 334 0.0850252750467773 530 6752301 YPR165W RHO1
SGTC_984 1492-0255 2.91 µM 1.37184263451069 0.0954668414346706 no 335 0.0850562158530008 458 1585198
SGTC_3017 9080681 49.47 µM 1.37076166981486 0.0956419902995741 no 336 0.0852246316445916 481 16451914
SGTC_1170 0310-0127 64.8 µM 1.36744999972668 0.0961800523287386 no 337 0.0857421496784001 515 774975
SGTC_1261 0712-0010 12.7 µM 1.36696055642418 0.0962597627663903 no 338 0.0858188345898339 541 2840123
SGTC_3318 9139014 38.6185 µM 1.3665674660473 0.0963238163758156 no 339 0.0858804602961143 463 16643984
SGTC_652 0437-0092 114 µM 1.36551695621934 0.0964951494112547 no 340 0.0860453137170429 467 3091274
SGTC_2743 auranofin 4.32 µM 1.36542988093099 0.0965093610091085 no 341 0.0860589888048098 473 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2924 9010168 62.78 µM 1.36159199782216 0.0971372721439983 no 342 0.0866633410244165 526 2993929
SGTC_705 1124-0212 310 µM 1.35644024106326 0.0979848508783704 no 343 0.0874795684717827 527 9554485
SGTC_2690 usnic acid 100 µM 1.35555574877577 0.0981309130233064 no 344 0.0876202797342604 582 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_266 formosanin C 406 nM 1.35436540591231 0.0983277340261924 no 345 0.0878099143410133 537 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_33 0986-0033 35.816 µM 1.3529982977185 0.0985541393720677 no 346 0.0880280871027874 465 2848082
SGTC_702 1488-0190 94 µM 1.35181930578567 0.0987496972683958 no 347 0.0882165633122947 494 949357
SGTC_199 4063-0024 41.6 µM 1.35058547698564 0.0989546548271962 no 348 0.0884141277952391 496 306215
SGTC_1426 4048-4480 71.7 µM 1.34886715245609 0.099240612685686 no 349 0.0886898202609756 534 14224343
SGTC_1697 st025554 27.742 µM 1.3471149944835 0.0995328227141898 no 350 0.0889715998140861 476 1269519
SGTC_883 0850-0245 24.6 µM 1.34642926672608 0.0996473536032932 no 351 0.0890820588338975 547 6823229 YPR165W RHO1
SGTC_1072 oxiconazole 14.9 nM 1.34569221109963 0.0997705646665599 no 352 0.0892008996710539 554 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1362 1611-0397 101 µM 1.34510085687269 0.0998694997649421 no 353 0.0892963332758908 517 27816
SGTC_1581 himbacine 57.9 µM 1.34455837602164 0.0999603212219404 no 354 0.0893839464096319 539 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_440 fluspirilene 35.1 µM 1.34190925902856 0.100404699570453 no 355 0.0898127096207025 536 3396 An atypical antipsychotic.
SGTC_232 clozapine 119 µM 1.34066289729119 0.100614269517444 no 356 0.0900149630118507 519 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_898 1000-0849 28.3 µM 1.34037268809948 0.10066311261259 no 357 0.0900621052562149 519 6751807
SGTC_676 falcarinol 140 µM 1.33473751566767 0.101614960093471 no 358 0.0909811352062889 539 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1205 4161-2785 76 µM 1.33467383889522 0.101625753175289 no 359 0.0909915597364775 457 3498106
SGTC_964 1287-0107 19.4 µM 1.33466929488307 0.1016265234079 no 360 0.0909923036709858 561 51516812 YPR165W RHO1
SGTC_2225 6654152 15.4 µM 1.33452326266923 0.101651278856373 no 361 0.0910162141088409 429 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1130 3454-2858 15.9 µM 1.33245773045345 0.102001899211447 no 362 0.0913549112627228 540 715628 YIL048W NEO1
SGTC_1291 0993-0025 5.79 µM 1.33018925609429 0.102387981695393 no 363 0.0917279615789469 523 4353356
SGTC_1816 st051957 91.6 µM 1.3297406459706 0.102464458486001 no 364 0.0918018689285895 499 674121
SGTC_2262 9014885 67.46 µM 1.32914710306599 0.102565706502898 no 365 0.0918997213532185 414 6457424
SGTC_3232 9132874 49.47 µM 1.32790172418185 0.102778382670698 no 366 0.0921052875370753 493 3784940
SGTC_593 1203-0218 61.7 µM 1.32776527493082 0.10280170388302 no 367 0.0921278309592595 538 3666956
SGTC_2019 4016004 108 µM 1.32478672253025 0.103311741399256 no 368 0.0926209499102394 467 45595336
SGTC_2389 9091542 195.52 µM 1.31791826819062 0.104494870274011 no 369 0.0937655047996831 570 3626624 YOL127W RPL25
SGTC_3170 9103054 49.47 µM 1.31757488544997 0.104554276428629 no 370 0.0938229987158878 480 16432970
SGTC_2967 9089538 49.85 µM 1.31600645942621 0.104825929523887 no 371 0.0940859373218036 568 728216
SGTC_2402 5553605 200 µM 1.31517975490991 0.10496932116011 no 372 0.0942247487264983 549 6758546
SGTC_728 3030-5151 22.5 µM 1.31391662962155 0.105188683966534 no 373 0.0944371308999569 497 3125388
SGTC_1652 st011932 78 µM 1.31303069397877 0.105342739292049 no 374 0.0945863027907358 515 1551076
SGTC_1531 st059297 52.4 µM 1.31151703427947 0.105606327087815 no 375 0.0948415712640742 551 7566702
SGTC_607 4491-0986 66.8 µM 1.30623534432615 0.106529812254458 no 376 0.0957362683850401 561 698981 YDR232W HEM1
SGTC_2580 diallyl disulphide 81.36 µM 1.30557135909545 0.106646319019249 no 377 0.0958491827392567 515 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_69 0096-0274 206.684 µM 1.30553005999762 0.106653568639354 no 378 0.0958562091133357 615 6741392
SGTC_1556 plumbagin 1.48 µM 1.30375110868981 0.106966182461212 no 379 0.0961592286706349 472 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1088 bifonazole 369 nM 1.29972104121139 0.107676826917257 no 380 0.0968482980289971 526 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_431 k089-0097 107 µM 1.29874405882692 0.107849614802348 no 381 0.0970158891997675 618 5499420
SGTC_2423 st077119 87.2 µM 1.2968872252967 0.108178562340373 no 382 0.0973349962916201 550 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_286 k060-0067 22.9 µM 1.29526096916087 0.108467254643265 no 383 0.0976151093528481 523 5985051
SGTC_179 1273-0063 6.77 µM 1.29193925241174 0.109058645836582 no 384 0.0981890914317737 493 3108139
SGTC_3347 9188721 44.724 µM 1.28315133443811 0.110634393992363 no 385 0.0997195309525495 515 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1204 4049-0315 18.3 µM 1.28300347170821 0.110661045896755 no 386 0.0997454298914547 547 588402
SGTC_2759 disulfiram 3.38 µM 1.28184030756469 0.110870863939384 no 387 0.0999493356322624 534 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1228 0124-0032 52.5 µM 1.27950131468194 0.111293646990404 no 388 0.100360288476295 579 X1228
SGTC_2947 9072639 7.68 µM 1.27878444124872 0.111423455727179 no 389 0.100486487161488 594 16488146
SGTC_340 k038-0059 454 µM 1.2783337186836 0.111505126331682 no 390 0.100565891801657 567 23733424
SGTC_2856 9022925 19.48 µM 1.27833291383453 0.111505272208059 no 391 0.100566033634357 580 4944862
SGTC_1210 3013-0140 750 nM 1.27572234653382 0.111979148217459 no 392 0.101026843120346 576 905973
SGTC_406 estrone 100 µM 1.27398713792225 0.112294922750933 no 393 0.101333987264005 573 5870 A steroid.
SGTC_301 4119-0100 24.5 µM 1.27345097919772 0.112392621871099 no 394 0.101429028570212 619 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1445 4239-0156 97.7 µM 1.26582456269264 0.113788891249399 no 395 0.102787949555355 658 4008346
SGTC_3098 9119039 49.47 µM 1.26435242733845 0.114059832038962 no 396 0.103051779914747 578 17161528
SGTC_3029 9088683 49.47 µM 1.26143635811704 0.114597879338651 no 397 0.103575837925276 557 25236615
SGTC_2888 9058547 12.99 µM 1.26071799779173 0.114730701683715 no 398 0.103705233598478 479 16476514
SGTC_1739 st037196 92.5 µM 1.25741842836599 0.115342187647659 no 399 0.104301079817253 608 612214
SGTC_1009 4106-0057 9.87 µM 1.25732122225177 0.115360237230663 no 400 0.104318671138005 592 2928005
SGTC_2570 licareol 100 µM 1.25674498901374 0.115467275525296 no 401 0.104422995808326 580 443158
SGTC_2426 5582046 32.21 µM 1.25631936750651 0.115546382216366 no 402 0.104500101367725 596 2251934
SGTC_291 SEC14.278 35.5 µM 1.25231465524514 0.116292590432123 no 403 0.105227615394361 609 1068044
SGTC_553 k007-0256 45.7 µM 1.25143905906278 0.116456197014026 no 404 0.105387167198095 583 6287000
SGTC_906 1165-0455 526 µM 1.24884989814923 0.116940940968397 no 405 0.105859989741655 571 3252859
SGTC_2010 4012422 159 µM 1.24613568381327 0.11745063092024 no 406 0.106357293148923 605 952393
SGTC_594 1487-1584 10.8 µM 1.24492096311149 0.117679246575069 no 407 0.106580402173781 590 5013332
SGTC_493 zm226600 134 µM 1.24159412540401 0.118306983725318 no 408 0.107193175170565 600 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1272 0839-0021 27 µM 1.24069627601338 0.118476802819145 no 409 0.107358985264017 616 5027250
SGTC_2724 maprotiline 69.64 µM 1.24039356010097 0.118534097276328 no 410 0.107414930898415 611 4011 A tricyclic antidepressant.
SGTC_2929 9013348 24.6 µM 1.23981750998151 0.1186431792491 no 411 0.107521450101025 579 2995952
SGTC_1671 st016596 74.5 µM 1.23969510555217 0.118666367124302 no 412 0.107544094084187 630 2829167
SGTC_3229 9132204 49.47 µM 1.23950591282208 0.118702213445007 no 413 0.107579100207144 528 17682924
SGTC_1301 naphtanilide LB 4.81 µM 1.23750049674588 0.119082649721463 no 414 0.10795066501558 620 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_948 3448-0295 75.3 µM 1.2327247991281 0.119992084262945 no 415 0.108839228129974 650 678569
SGTC_3307 9126885 69.2785 µM 1.23249331229518 0.12003629028538 no 416 0.108882431647689 617 24824909
SGTC_489 paxilline 115 µM 1.23226662711587 0.120079590479579 no 417 0.1089247509564 552 105008 A toxic potassium channel blocker.
SGTC_2068 5226020 147 µM 1.23140516547262 0.120244242688406 no 418 0.109085682998458 634 1810509
SGTC_1904 st060225 78 µM 1.22663164306395 0.12115949451131 no 419 0.109980535224676 585 66595
SGTC_3173 9105693 49.47 µM 1.22439513202834 0.121589993715593 no 420 0.110401602406213 620 17096658
SGTC_353 1988-1175 58.3 µM 1.22310853435494 0.121838133551491 no 421 0.110644352811598 558 2788357
SGTC_1339 1486-1321 22.7 µM 1.22193853265205 0.122064094758731 no 422 0.110865436228705 621 3469382
SGTC_1440 4100-1550 40 µM 1.22060154600305 0.122322665685632 no 423 0.111118460353774 549 742806
SGTC_131 0141-0277 33.849 µM 1.21947111014106 0.122541589805948 no 424 0.111332717246377 606 1547771
SGTC_3027 9089541 49.47 µM 1.21754440181531 0.122915356096362 no 425 0.111698576702948 635 9943819
SGTC_2933 9026794 32.47 µM 1.21588716755737 0.1232374854009 no 426 0.112013953546834 626 17586027
SGTC_1143 3454-2408 5.08 µM 1.21489516380733 0.123430591567096 no 427 0.112203039280807 562 X1143
SGTC_349 k015-0014 24 µM 1.21328234975351 0.123744998628807 no 428 0.112510944361302 574 2196908
SGTC_827 3253-0474 693 µM 1.21092037260859 0.124206461066237 no 429 0.11296296192713 653 5402065
SGTC_2079 5212404 121 µM 1.21088623081689 0.124213140205142 no 430 0.1129695052182 596 758462
SGTC_1679 SEC14.276 6.7 µM 1.20873693305945 0.124634111913447 no 431 0.113381963871969 677 1005053 YMR079W SEC14
SGTC_1192 1488-0095 21.4 µM 1.20861016928769 0.12465897157609 no 432 0.113406323833897 584 915875
SGTC_2456 5770359 74.46 µM 1.20694874340106 0.124985114474418 no 433 0.113725942108692 624 3118787
SGTC_3163 9099914 49.47 µM 1.20669970395229 0.125034052989217 no 434 0.113773906573837 552 16268368
SGTC_2992 9074591 71.4286 µM 1.20568534102988 0.125233522796829 no 435 0.113969419660651 601 17741321
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.20162024570729 0.126035134076854 no 436 0.114755346904922 660 676296 Flavone; oxidizing agent.
SGTC_2195 6536160 144.242 µM 1.1989281077564 0.126567971844569 no 437 0.115277950631766 551 3834386
SGTC_2563 tomatine 8.54 µM 1.19635324136046 0.127079064945326 no 438 0.1157793700539 693 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1907 st060210 83.7 µM 1.19497487653408 0.127353250205834 no 439 0.116048423056815 691 688793
SGTC_1014 4130-3005 69.3 µM 1.1943796068029 0.127471788792456 no 440 0.116164755182175 647 743608
SGTC_1847 st056231 15 µM 1.19379277093021 0.127588722990756 no 441 0.116279520087778 674 5393180
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.19142431890322 0.128061423713307 no 442 0.11674352533571 701 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1404 3909-7820 48.3 µM 1.18809353978538 0.128728243969059 no 443 0.117398279621351 622 23741373
SGTC_2221 6807166 181.081 µM 1.18717298037096 0.128912963637096 no 444 0.117579698144648 543 674925
SGTC_1696 st025591 34.7925 µM 1.1870801532413 0.128931600549336 no 445 0.117598002987594 646 2787147
SGTC_2190 6049624 200 µM 1.18545478759237 0.129258228209699 no 446 0.11791884035146 556 2265554
SGTC_2376 9072922 81.32 µM 1.18222619320521 0.129908735015483 no 447 0.118557981062407 649 17087968
SGTC_875 0709-0210 25.7 µM 1.18200387521964 0.129953611563263 no 448 0.118602081610687 673 6251364
SGTC_3167 9103034 49.47 µM 1.18029354242196 0.130299213887187 no 449 0.118941742803094 569 5127859
SGTC_933 2914-0560 114 µM 1.17955372053552 0.130448904528859 no 450 0.119088879350702 703 463887
SGTC_3067 9117431 49.47 µM 1.17928626914295 0.130503048124408 no 451 0.119142101973454 581 17150885
SGTC_1713 st033146 12.748 µM 1.17916437088883 0.130527730697401 no 452 0.119166365202674 647 674619
SGTC_3137 9097352 49.47 µM 1.176558097672 0.131056234524692 no 453 0.119685965380204 687 44120435
SGTC_1929 genistein trimethyl ether 50.5 µM 1.17209410589047 0.131964879931518 no 454 0.120579638032926 640 136420
SGTC_410 α-linolenic acid 100 µM 1.17107731820299 0.132172453152138 no 455 0.120783850009096 678 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_478 N-arachidonylglycine 10 µM 1.17012137750787 0.132367809898161 no 456 0.120976063356791 505 5283389
SGTC_1247 0448-0043 5.84 µM 1.16943917212084 0.13250734752109 no 457 0.121113367610686 683 3089013 YGL099W LSG1
SGTC_997 3996-0078 137 µM 1.16875264218486 0.132647871967455 no 458 0.121251652875079 664 735687
SGTC_965 1291-5240 308 µM 1.16748253752307 0.132908117720099 no 459 0.121507778161885 679 2834598
SGTC_206 4546-0025 72.014 µM 1.16263480901057 0.13390465260661 no 460 0.122488850785413 737 6620745 YIL048W NEO1
SGTC_3206 9114350 49.47 µM 1.16026233584043 0.13439422255598 no 461 0.122971007105582 615 17087243
SGTC_1948 st076329 66.6 µM 1.15834191846976 0.134791407865475 no 462 0.123362265669645 600 24208413
SGTC_2335 9018011 154.17 µM 1.15660433045586 0.135151473352651 no 463 0.12371702610236 694 6458208
SGTC_151 3013-0144 2.285 µM 1.15390365835254 0.135712418603051 no 464 0.124269834587025 676 906558 YHR107C CDC12
SGTC_24 0417-1663 219 µM 1.14964733645792 0.136599714592066 no 465 0.125144576578861 645 4329390
SGTC_3030 9087619 49.47 µM 1.14919404235874 0.136694443950368 no 466 0.125237988469817 625 25236973
SGTC_1927 st060202 13.8 µM 1.14752652832918 0.137043307340282 no 467 0.125582037790967 649 688887
SGTC_3196 9111891 49.47 µM 1.14610268469404 0.137341673144443 no 468 0.12587633344904 638 18891510
SGTC_1313 1220-0047 237 µM 1.14351944189584 0.137884122306406 no 469 0.12641149365638 709 3528706
SGTC_3026 9090633 49.47 µM 1.14270533840535 0.138055376493625 no 470 0.126580476298976 667 25236842
SGTC_773 4358-1457 44.6 µM 1.14254516073803 0.138089088415948 no 471 0.126613742731511 721 1186886
SGTC_837 0091-0265 12.5 µM 1.1399492583236 0.138636219883428 no 472 0.127153720754983 703 759367
SGTC_2307 7538926 6.34 µM 1.13574781365911 0.139524872952301 no 473 0.128031061762565 689 96582
SGTC_3221 9128209 49.47 µM 1.13562532939885 0.139550837745273 no 474 0.128056701720892 633 16460723
SGTC_2205 7238770 200 µM 1.13520148284386 0.139640712102563 no 475 0.128145454181992 650 279867
SGTC_501 nsc-95397 161 µM 1.13496356259652 0.139691179040857 no 476 0.128195292833768 655 262093
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.13313254815864 0.140079983338836 no 477 0.128579297398827 712 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_407 eburnamonine 100 µM 1.13070814612212 0.140595920011147 no 478 0.129088975773876 607 3195
SGTC_3078 9116413 49.47 µM 1.13038122669144 0.140665590255524 no 479 0.129157810583804 608 17177322
SGTC_1320 1313-0481 95.3 µM 1.12889166938814 0.140983328397254 no 480 0.129471767724772 695 6813365 YLR208W SEC13
SGTC_1662 st014054 52 µM 1.12784481506269 0.141206924431085 no 481 0.129692731571846 652 2838777
SGTC_1086 cerivastatin 2.18 µM 1.12732449397202 0.141318148426006 no 482 0.129802654997875 653 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2674 ligustilide 100 µM 1.12565763744037 0.141674855938892 no 483 0.130155230663202 639 5319022 A signalling regulator.
SGTC_4 0960-0234 25.671 µM 1.12464951236214 0.141890890573649 no 484 0.130368791922644 631 6821112
SGTC_2887 9044784 58.44 µM 1.11318009318536 0.144364416245063 no 485 0.132815545245306 747 6465546
SGTC_725 1497-0963 19 µM 1.11239144290429 0.144535560077736 no 486 0.132984941109847 720 3549977
SGTC_2859 9028643 45.46 µM 1.10743624838173 0.145614006484518 no 487 0.134052680566705 660 17151580
SGTC_503 tyrphostin 8 294 µM 1.10502277556211 0.146141228085686 no 488 0.134574860196855 685 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2184 6075246 200 µM 1.10361374788247 0.146449621368191 no 489 0.134880362473247 702 2267320
SGTC_2029 5175081 200 µM 1.10322899734339 0.146533907432585 no 490 0.13496386586737 744 1380876
SGTC_730 1436-0052 41.2 µM 1.10187456936997 0.14683087662857 no 491 0.135258102921829 660 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_111 0083-0039 52.457 µM 1.10148684835051 0.146915961848453 no 492 0.13534241265651 563 759313
SGTC_2318 6029776 164 µM 1.10083414495425 0.14705927202353 no 493 0.135484424017292 701 818325
SGTC_13 0199-0087 65 µM 1.09832600625921 0.1476108409438 no 494 0.136031079925328 720 4589825
SGTC_224 benfluorex 43.875 µM 1.0982573387542 0.147625961190841 no 495 0.136046067406392 630 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1505 k297-0037 20.6 µM 1.09465826584085 0.14841991158636 no 496 0.136833189431246 721 4089396
SGTC_2949 9072542 2.23 µM 1.09401581989972 0.148561934070199 no 497 0.13697401997685 709 16457352
SGTC_2984 9022109 38.96 µM 1.09069120690418 0.149298341964506 no 498 0.137704390528725 682 6459207
SGTC_1358 1509-0022 2.48 µM 1.08876466057838 0.149726189011277 no 499 0.138128839683312 718 3258434
SGTC_2776 terbinafine 19.92 µM 1.08624962177613 0.150285958106047 no 500 0.138684284428004 680 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_371 0195-0006 7.36 µM 1.0858857548194 0.1503670588599 no 501 0.13876477002534 643 3928593
SGTC_2024 5144227 134 µM 1.0851931206169 0.150521517715871 no 502 0.138918065236716 764 3475211
SGTC_2308 7584454 197.62 µM 1.08382748773031 0.150826366176589 no 503 0.13922064757524 758 893577
SGTC_2552 juarezic acid 87.02 µM 1.08139216773973 0.151371018864814 no 504 0.139761352081031 844 1549512
SGTC_2869 9037858 32.47 µM 1.0804894636406 0.151573238039927 no 505 0.139962138100705 670 27187042
SGTC_1695 st026914 34.495 µM 1.07869532988246 0.151975683679817 no 506 0.140361784124925 734 3289191
SGTC_3241 9133421 49.47 µM 1.07859699309024 0.151997762296189 no 507 0.140383711172815 704 17018221
SGTC_598 3937-0236 20.2 µM 1.07822906857115 0.152080387754939 no 508 0.14046577127573 779 1379313
SGTC_803 4488-1585 147 µM 1.07800363592512 0.152131028296874 no 509 0.140516066768177 728 747204
SGTC_3129 9127257 49.47 µM 1.07771644944339 0.152195557260122 no 510 0.140580157649608 624 837894
SGTC_3270 9137563 49.47 µM 1.07770236947979 0.152198721405044 no 511 0.140583300359488 672 17015724
SGTC_2241 6772625 37.8075 µM 1.07590070310897 0.152603964473861 no 512 0.140985833725876 686 2285411
SGTC_417 st075190 100 µM 1.07496657398827 0.152814356698661 no 513 0.141194846922259 760 222757
SGTC_1098 clofazimine 15.1 µM 1.0735748541559 0.153128167884719 no 514 0.141506636411607 770 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2726 cimetidine 79.27 µM 1.06612422015712 0.154815429428175 no 515 0.143183746143924 656 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2568 diosmetin 100 µM 1.06494256826698 0.155084148993688 no 516 0.143450960031021 776 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_339 3091-4833 71.4 µM 1.05959378939666 0.15630436520759 no 517 0.144664720133935 737 3240077
SGTC_1979 st071809 45.3 µM 1.05950201614847 0.15632535646125 no 518 0.144685605765317 764 4976333
SGTC_2467 5474540 200 µM 1.0594292460075 0.156342002462626 no 519 0.144702168138959 737 5413519
SGTC_2391 6285546 200 µM 1.05886922106141 0.156470145936411 no 520 0.144829671694176 762 846083
SGTC_3031 9088762 49.47 µM 1.05571345677402 0.157193532428123 no 521 0.145549573642654 763 205253
SGTC_1021 4476-0760 85.3 µM 1.05533710648529 0.157279948623872 no 522 0.145635588065186 718 746768
SGTC_762 1165-0429 115 µM 1.05489268901862 0.157382034369335 no 523 0.145737203160998 752 5967793
SGTC_264 promethazine 12.5 mM 1.05295604070345 0.157827404124558 no 524 0.146180569902286 881 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1409 3909-8004 61.9 µM 1.05280181099346 0.157862907779574 no 525 0.146215917398628 775 2119279
SGTC_2659 sanguinarine 24.21 µM 1.05210151585699 0.158024181578494 no 526 0.146376488378465 729 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_767 0929-0023 86 µM 1.05179283857003 0.158095302452485 no 527 0.14644730270892 845 1204563
SGTC_2072 5231554 129 µM 1.05154587960409 0.158152218226821 no 528 0.146503974662341 788 789545
SGTC_99 0109-0120 622.8 µM 1.05128898650303 0.158211437755578 no 529 0.146562941912456 707 759414
SGTC_185 k048-0037 25.491 µM 1.04889747458413 0.158763432245574 no 530 0.147112653987822 782 6827589
SGTC_2452 5863136 48.41 µM 1.04755844584085 0.159073049534685 no 531 0.147421045573517 737 2184096
SGTC_252 miconazole 1.30953 nM 1.04679419601985 0.15924994061048 no 532 0.147597253918308 733 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_183 3914-0051 30.55 µM 1.04552369492969 0.159544292138329 no 533 0.147890497577381 759 1596232
SGTC_524 r073-0010 27.8 µM 1.03447158011718 0.16211987481143 no 534 0.150457878118523 749 2772106
SGTC_3120 9124077 49.47 µM 1.0327849837426 0.162515287073227 no 535 0.150852266261918 797 18774327 YGL155W CDC43
SGTC_2882 9058044 58.44 µM 1.0324796126499 0.162586946509768 no 536 0.150923746746522 722 18076804
SGTC_374 0880-0231 82.3 µM 1.03216849378272 0.162659975877425 no 537 0.150996595836465 778 6833587
SGTC_2787 5284540 71.43 µM 1.03203190471388 0.162692044360472 no 538 0.151028585824407 766 736958
SGTC_1501 4491-0275 38.4 µM 1.02823052130335 0.163586185707767 no 539 0.151920702280738 795 5104718
SGTC_1351 1496-0003 46.5 µM 1.02779255982178 0.163689405298428 no 540 0.152023708417676 809 3891978
SGTC_3290 9121031 71.43 µM 1.02518108995162 0.164305758945292 no 541 0.152638874566281 701 17014854
SGTC_1959 st077091 55.8 µM 1.02506900313259 0.164332247077772 no 542 0.152665315002869 793 821356 YKL052C ASK1
SGTC_1943 st076331 65.2 µM 1.02394693935524 0.164597563514615 no 543 0.152930168837094 809 24208415
SGTC_112 phenothiazine 287.218 µM 1.02388089889948 0.164613187687363 no 544 0.15294576662542 812 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.02381033379366 0.164629883385887 no 545 0.152962434235404 794 2724 A muscle relaxant with antifungal properties.
SGTC_2056 5235370 200 µM 1.02293350544791 0.164837432423525 no 546 0.153169643178203 743 5511916
SGTC_1915 st067105 30.6 µM 1.02172253261086 0.165124353431612 no 547 0.153456121679268 759 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.01756426689862 0.166112048646594 no 548 0.154442538036313 798 5282309
SGTC_3046 9092212 49.47 µM 1.01396980967824 0.166968893999417 no 549 0.15529857916525 777 25236637
SGTC_3279 9140807 49.47 µM 1.01210368643754 0.167414861843467 no 550 0.155744239984955 793 45595718
SGTC_784 4579-0127 173 µM 1.01209610306652 0.167416675688878 no 551 0.155746052737067 849 1948547
SGTC_921 1561-0023 372 µM 1.01114682209376 0.167643831566371 no 552 0.155973081632752 817 24050882
SGTC_57 miconazole 162.5 nM 1.006140943505 0.168844982646276 no 553 0.157173887855317 752 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2835 9006588 71.43 µM 1.00576955869469 0.168934315525234 no 554 0.157263216949082 728 2345538
SGTC_1818 st052136 56.3 µM 1.00352665312875 0.169474469119344 no 555 0.157803411844751 756 674169
SGTC_2700 st077718 96.8 µM 1.00337638528769 0.169510697333998 no 556 0.157839646764941 740 904970
SGTC_1498 4478-3555 97.6 µM 1.00281256326819 0.169646674010253 no 557 0.157975653014612 769 3437919
SGTC_2181 6316240 54.2555 µM 1.00165671092449 0.169925649023685 no 558 0.158254710456032 735 12779990
SGTC_2628 lathosterol 100 µM 0.999684864185217 0.170402249813483 no 559 0.158731519588009 802 6710616
SGTC_2990 9074105 71.4286 µM 0.999221363624921 0.170514403333603 no 560 0.158843734489617 771 6502001
SGTC_789 1309-1135 70.6 µM 0.999211818797186 0.170516713398125 no 561 0.158846045867836 787 3092424
SGTC_976 1348-1067 47.6 µM 0.998362045724809 0.170722458040594 no 562 0.159051915504937 861 5310671 YGL099W LSG1
SGTC_3349 9149703 23.001 µM 0.997649153974869 0.170895183878331 no 563 0.159224758469601 783 4910494
SGTC_1680 diphenhydramine 100 µM 0.997513687149514 0.170928018639619 no 564 0.159257616753955 777 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1568 digitonin 820 nM 0.996571607346917 0.171156473738971 no 565 0.15948624662984 855 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2753 fluvastatin 17.09 µM 0.996282619567533 0.171226592623296 no 566 0.159556423050874 811 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1761 st044296 37 µM 0.993974523475597 0.171787279228499 no 567 0.160117635364034 789 1826700
SGTC_2248 tofa 1.1 µM 0.993706482929247 0.171852468001092 no 568 0.160182892816602 778 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2122 5258151 111.688 µM 0.992035710130949 0.172259164178106 no 569 0.160590052931112 798 2173356
SGTC_2817 7995342 71.43 µM 0.99095965591275 0.172521419997335 no 570 0.16085264027528 718 18879975
SGTC_567 1080-0542 68.4 µM 0.989573998522023 0.172859507109562 no 571 0.161191192115346 757 5950415
SGTC_3171 9103192 49.47 µM 0.987308701311137 0.173413126576728 no 572 0.16174566314471 815 13018434
SGTC_1427 4048-4900 550 nM 0.987147403667407 0.17345258935298 no 573 0.161785190905504 834 24132586
SGTC_2610 ononetin 44.17 µM 0.986576453683254 0.173592322817517 no 574 0.161925159048362 804 259632
SGTC_1233 0325-0408 14.2 µM 0.984959822548993 0.173988363176159 no 575 0.162321903259609 817 12874
SGTC_2412 st077135 33.4 µM 0.984078157663121 0.174204594273988 no 576 0.162538542759378 805 13258915
SGTC_655 k060-0012 42 µM 0.982742812667651 0.174532416912209 no 577 0.162867016971918 796 5994525
SGTC_211 3455-0679 143.504 µM 0.982051590833509 0.174702263303484 no 578 0.163037216278303 839 748649
SGTC_683 panaxydol 45 µM 0.980254938786544 0.175144225638432 no 579 0.163480145875817 846 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_72 0744-0168 198.391 µM 0.979825489022702 0.175249971843804 no 580 0.163586133976104 794 677577
SGTC_2874 9043904 71.43 µM 0.979551273859924 0.175317514800503 no 581 0.163653833548798 731 4463428
SGTC_1545 lovastatin 49.4 µM 0.978890000549673 0.175480463374077 no 582 0.163817166730197 870 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2031 5180455 200 µM 0.978348288058974 0.17561402171163 no 583 0.163951047436532 789 29949
SGTC_1794 st048918 76.9 µM 0.977873655274828 0.17573109458492 no 584 0.164068408165944 761 672303
SGTC_1231 0242-0792 125 µM 0.977173730277694 0.17590382820769 no 585 0.164241575497815 824 3707635
SGTC_3244 9134489 49.47 µM 0.975954113075834 0.17620507284847 no 586 0.164543602141283 804 16584271
SGTC_1139 k015-0024 46.9 µM 0.975339938325339 0.176356897143843 no 587 0.164695832882518 832 2766652
SGTC_1256 0570-0116 285 µM 0.975307600275819 0.176364893418385 no 588 0.164703850792442 772 410638
SGTC_3192 9110362 49.47 µM 0.974310002483853 0.176611683496261 no 589 0.164951319847996 855 16649480
SGTC_2838 9002687 71.43 µM 0.973714983307101 0.176758985846685 no 590 0.165099037830562 758 6457060
SGTC_1958 st076513 41.9 µM 0.973464389245425 0.176821045897225 no 591 0.165161275309516 810 732122 YGL099W LSG1
SGTC_95 0471-0001 561.058 µM 0.973454922589117 0.176823390600891 no 592 0.165163626743571 784 4015405
SGTC_841 0251-0215 91.2 µM 0.973022397436043 0.176930539493849 no 593 0.165271085294857 871 3888614
SGTC_2620 irigenin 100 µM 0.972464584092716 0.177068786434477 no 594 0.165409737810113 853 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1616 st002734 56.1 µM 0.971336343111486 0.177348615151103 no 595 0.165690408273605 860 4026101
SGTC_507 nimesulide 162 µM 0.970058954219138 0.177665772678466 no 596 0.166008553462005 842 4495 A COX2 inhibitor.
SGTC_1468 k284-1086 134 µM 0.969746550704545 0.177743392468368 no 597 0.166086420401038 884 15996457
SGTC_2489 cantharidin 73.42 µM 0.968531375521725 0.178045518357948 no 598 0.166389528597838 817 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_879 0831-1030 162 µM 0.968481464468423 0.178057934533791 no 599 0.166401985833245 852 1549252
SGTC_2544 sphondin 68.51 µM 0.966450282993491 0.178563686632858 no 600 0.166909456676456 800 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3070 9117005 49.47 µM 0.965318938591245 0.178845776566908 no 601 0.167192544410409 794 8779016
SGTC_1175 0741-0056 27.6 µM 0.963017901458296 0.179420383097067 no 602 0.167769269847598 920 765927
SGTC_1040 k898-0338 155 µM 0.962821508712195 0.179469479270382 no 603 0.167818552431375 903 20969351
SGTC_775 4577-0580 57.3 µM 0.962456231578148 0.179560817268108 no 604 0.16791023946837 846 2006902
SGTC_1933 st074711 15.9 µM 0.962028445400031 0.179667822865015 no 605 0.168017657686252 869 17250958
SGTC_1161 k007-0610 110 µM 0.958265801803542 0.180610728596475 no 606 0.168964371878913 934 5843850
SGTC_1371 2421-0008 32.7 µM 0.957543423310197 0.180792108647559 no 607 0.169146519975221 802 2827552
SGTC_52 0329-0193 875 nM 0.957274211288977 0.180859733558343 no 608 0.169214434158457 817 3739292
SGTC_3005 9076496 71.4286 µM 0.956163716388223 0.181138852692313 no 609 0.169494764002989 836 21368410
SGTC_2120 5538279 151.968 µM 0.954914494421239 0.181453162722388 no 610 0.169810469617667 853 2058197
SGTC_2000 st075254 36.4 µM 0.953831479631785 0.181725930379899 no 611 0.170084476018321 827 17234175
SGTC_770 0389-1121 67.2 µM 0.952973601910803 0.181942177094432 no 612 0.170301722992154 896 6753108
SGTC_673 1082-0474 110 µM 0.95233365328534 0.182103594795419 no 613 0.170463897813672 928 3098046
SGTC_1940 st075990 51.1 µM 0.950072402519827 0.182674679049336 no 614 0.17103773242522 905 1084979
SGTC_2252 omeprazole 400 µM 0.946544862961616 0.183567797649512 no 615 0.171935375642328 771 4594 A proton pump inhibitor.
SGTC_1408 3909-7976 48.8 µM 0.94624696824664 0.18364334440124 no 616 0.17201131757242 896 24152374
SGTC_3001 9076041 71.4286 µM 0.945439496024439 0.18384821853274 no 617 0.172217273130657 849 16004211
SGTC_1700 st030840 7.9285 µM 0.944662290226954 0.184045547777445 no 618 0.172415657428093 889 5499307
SGTC_878 0828-0289 13.7 µM 0.944412488187747 0.184108999443666 no 619 0.172479451150315 856 745350 YLR208W SEC13
SGTC_1102 cgs 12066b 26.1 µM 0.944142800094822 0.184177517607333 no 620 0.172548340212183 821 6438352 A 5-HT1B full agonist.
SGTC_894 0960-0238 55.9 µM 0.942825134341574 0.184512517826671 no 621 0.172885176676024 893 6741907 YDL195W SEC31
SGTC_2519 cryptotanshinone 88.04 µM 0.941386395472337 0.184878731901505 no 622 0.173253441402347 871 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1482 3346-2049 8.48 µM 0.939598274660313 0.185334506138641 no 623 0.173711830809555 847 3826804
SGTC_2336 9001819 198.65 µM 0.938418308066334 0.185635649630561 no 624 0.174014740461056 884 2989602
SGTC_3097 9117246 49.47 µM 0.933889996656099 0.186794152046127 no 625 0.175180319713175 872 16423892
SGTC_2807 7945238 51.95 µM 0.9328722443828 0.187055143709037 no 626 0.175442967290712 860 17148797
SGTC_50 0929-0078 56.389 µM 0.930202868053582 0.187740747664473 no 627 0.176133028606951 810 1377751
SGTC_93 0109-0045 59.227 µM 0.930185066642913 0.187745324991533 no 628 0.176137636214552 1029 88733
SGTC_42 0133-0086 60.653 µM 0.928869111617877 0.188083891105696 no 629 0.176478461193759 817 162923 Model of phenazepam hydroxylation.
SGTC_1243 0416-0003 5.65 µM 0.92886415745757 0.188085166413138 no 630 0.176479745081207 844 2141977
SGTC_1087 pterostilbene 9.05 µM 0.928495303388605 0.188180132376922 no 631 0.176575351459266 904 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2630 antimycin a 100 µM 0.928395018706354 0.188205957002524 no 632 0.176601350749063 921 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_751 0833-0568 350 µM 0.927696269182611 0.188385954898536 no 633 0.176782572141824 874 6954252
SGTC_621 3584-0052 32.1 µM 0.927266152059073 0.188496805860768 no 634 0.176894181881544 916 2273927
SGTC_2139 5578692 56.4705 µM 0.92560513619884 0.188925264896972 no 635 0.177325611594537 841 650991 YMR113W FOL3
SGTC_2710 st078562 53.7235 µM 0.925184636316963 0.189033827944615 no 636 0.177434936891812 903 17250908
SGTC_1183 1254-0324 198 µM 0.9246346758248 0.189175872615618 no 637 0.177577984710709 885 5799357
SGTC_904 1141-0088 396 µM 0.923906831156604 0.189363962514575 no 638 0.177767413071224 846 1378119
SGTC_3182 9108849 49.47 µM 0.923187652439728 0.189549925972554 no 639 0.177954711196398 910 17133045
SGTC_1989 st071868 50.2 µM 0.918956418305309 0.190646301784389 no 640 0.179059184104104 922 16414057
SGTC_2084 5306078 60.6385 µM 0.918919121123132 0.190655983314504 no 641 0.17906893886959 854 679340
SGTC_1047 2043-3044 82 µM 0.918338085080387 0.190806846489187 no 642 0.179220947150649 908 669592
SGTC_2989 9073649 71.4286 µM 0.917058594429532 0.191139318148353 no 643 0.179555968307073 953 21367202
SGTC_466 geldanamycin 89.2 µM 0.913456361976835 0.19207725311464 no 644 0.180501287188591 798 5288382 HSP90 inhibitor.
SGTC_2761 levamisole 97.89 µM 0.91278867939382 0.192251410522014 no 645 0.180676846682185 877 26879 An alkaline phosphatase inhibitor.
SGTC_2686 alizarin 95.37 µM 0.910829350952913 0.192763036395228 no 646 0.181192647490767 839 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_48 0382-0018 55 µM 0.910515674675565 0.192845021692024 no 647 0.181275309551874 874 762596
SGTC_969 1313-0238 134 µM 0.909265888970496 0.193171888553339 no 648 0.181604895847322 920 5212874
SGTC_2063 5246145 200 µM 0.907409024339714 0.193658153887259 no 649 0.182095269489733 929 711240
SGTC_559 1550-0661 158 µM 0.907148749718176 0.193726372745121 no 650 0.182164070696648 900 5830875
SGTC_1833 st055984 71 µM 0.905362813192735 0.194194867821169 no 651 0.182636604786928 879 676288
SGTC_2705 st078069 42.8 µM 0.902880761520641 0.19484711578152 no 652 0.183294591080735 848 1530061
SGTC_1062 mesoridazine 14.2 µM 0.899592494074858 0.195713274768789 no 653 0.184168576545997 911 4078 A neuroleptic.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.899457329041951 0.195748928384072 no 654 0.184204557344858 932 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2816 7982706 58.44 µM 0.899253443361581 0.195802716479239 no 655 0.184258839788739 860 2981853
SGTC_2649 anisomycin 9.56 µM 0.89799840907434 0.196134010822106 no 656 0.184593198816221 899 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2292 7671323 168.05 µM 0.897177754068321 0.196350824752291 no 657 0.184812036894657 892 937504
SGTC_317 4495-0002 170 µM 0.89599216132005 0.19666431027923 no 658 0.185128474885267 873 15991618
SGTC_401 neomycin 50 µM 0.895619112317833 0.196763011764134 no 659 0.185228112263776 884 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1410 3909-8106 77.9 µM 0.894129803280076 0.197157352725583 no 660 0.185626222466852 907 1039210
SGTC_73 0327-0325 16.231 µM 0.892025993088916 0.197715216187075 no 661 0.18618950014592 1004 53298
SGTC_2315 7733312 200 µM 0.889676049046378 0.198339473075778 no 662 0.186819929085137 857 726316
SGTC_1965 Pectolinarigenin 58.4 µM 0.888196123597581 0.198733221368634 no 663 0.187217631791776 939 5320438 An anti-inflammatory.
SGTC_1716 st033144 30.6155 µM 0.887629997999994 0.198883969034362 no 664 0.187369905957757 962 674617
SGTC_2683 piperine 63.03 µM 0.884822136265481 0.199632663285465 no 665 0.188126284221076 895 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2884 9058502 51.95 µM 0.882614300770248 0.200222554610521 no 666 0.188722349612432 908 6471554
SGTC_2486 5283202 22.39 µM 0.877796758709458 0.201513340589353 no 667 0.190027011886928 866 1377751
SGTC_3099 9120367 49.47 µM 0.877262511003135 0.201656790497917 no 668 0.190172034826661 947 24824940
SGTC_2320 7373003 200 µM 0.87663264436189 0.201825993423253 no 669 0.190343101101298 951 5415828
SGTC_1392 3455-1037 33.9 µM 0.873632793245034 0.202633018079822 no 670 0.19115913074302 917 981132
SGTC_2451 5856223 45.7 µM 0.871809187058088 0.203124548676124 no 671 0.191656240932871 915 2179896
SGTC_2614 arthonioic acid 13.39 µM 0.871267864149943 0.203270592497688 no 672 0.191803956375275 912 6710684
SGTC_3303 9125618 40.5795 µM 0.870147232965788 0.203573127311081 no 673 0.192109974092411 986 22695467
SGTC_731 3966-0296 387 µM 0.869963409789089 0.203622779353456 no 674 0.192160200334188 935 660956
SGTC_506 n9-isopropylolomoucine 153 µM 0.868608875621249 0.203988871978013 no 675 0.192530549086607 960 6610355
SGTC_3327 9140648 26.9345 µM 0.86557064797534 0.204811444777596 no 676 0.193362828865508 956 8029710
SGTC_726 3448-4391 34.2 µM 0.86484362738972 0.205008571158627 no 677 0.193562310975621 992 1356692
SGTC_2593 nobiletin 86.24 µM 0.864175499007867 0.205189828754424 no 678 0.193745744697419 884 72344 An anti-infammatory.
SGTC_1399 3562-5772 25 µM 0.864017568496126 0.205232687881032 no 679 0.193789119782244 872 23847490
SGTC_1864 st057645 30.4 µM 0.863373005570114 0.205407664284292 no 680 0.193966208199609 972 688666
SGTC_2952 9073731 13.78 µM 0.861858297110693 0.205819203495211 no 681 0.194382750002961 1001 16457353
SGTC_2809 7964133 12.99 µM 0.861686465745147 0.205865920151276 no 682 0.194430037655266 931 1253665
SGTC_1530 rhein 70.4 µM 0.861291868916878 0.205973224979945 no 683 0.194538656425208 1029 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_935 2996-0153 430 µM 0.860589973564084 0.206164177107182 no 684 0.194731955026332 962 23738523
SGTC_237 nikkomycin 200 µM 0.860190491592346 0.206272903878515 no 685 0.194842022593701 968 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1258 0671-0043 57.1 µM 0.859286372520627 0.206519102896656 no 686 0.195091270358316 952 4298767
SGTC_1559 coumarin 343 70.1 µM 0.858246889307163 0.206802377684621 no 687 0.195378074729631 928 108770 A hepatotoxic, DNA x-linker.
SGTC_1819 st053448 58.6 µM 0.858116226946854 0.206838001407059 no 688 0.195414143963949 949 2857616
SGTC_2476 5806916 10.51 µM 0.85765866307661 0.206962780028041 no 689 0.195540485963539 931 2870194
SGTC_135 0933-0004 26.348 µM 0.857437419004555 0.207023129720826 no 690 0.195601593404095 900 21230617 YGL099W LSG1
SGTC_2488 5268135 45.7 µM 0.857123411888777 0.207108800659984 no 691 0.195688341828634 996 1270356 YLR208W SEC13
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.856450417566301 0.207292485139157 no 692 0.195874343646403 908 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.855686226076183 0.207501177374876 no 693 0.196085680510721 989 688751
SGTC_2365 9042475 200 µM 0.855018703279866 0.207683572028067 no 694 0.196270396801364 943 6464479
SGTC_1856 st057054 55.7 µM 0.85370244928479 0.208043504099089 no 695 0.196634938355762 994 1266018
SGTC_352 k048-0007 5.11 µM 0.853430408863751 0.208117939940819 no 696 0.196710332099973 1004 6811911
SGTC_1348 1493-0373 93.8 µM 0.853211928603008 0.208177732002795 no 697 0.196770894765836 960 3010129
SGTC_1332 1480-0653 17.5 µM 0.852266509874115 0.208436584023777 no 698 0.197033094693994 977 5749438
SGTC_2545 solidagenone 89.61 µM 0.849761132918614 0.209123463980988 no 699 0.197728951301912 771 6708572 An anti ulcer agent
SGTC_599 1935-0052 86.5 µM 0.84968422650461 0.209144569884203 no 700 0.197750335161885 1016 9557311
SGTC_2238 6671620 73.2395 µM 0.849675588339961 0.209146940587538 no 701 0.197752737094404 1008 729941
SGTC_3138 9097216 49.47 µM 0.849165249090466 0.209287028852746 no 702 0.197894673575255 1041 25237486
SGTC_1058 3448-5425 97.3 µM 0.848827455365111 0.209379783692004 no 703 0.197988655219724 952 7279705
SGTC_1097 itavastatin 7.23 µM 0.84653068053811 0.210011096629124 no 704 0.198628382955205 1009 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2881 9058953 51.95 µM 0.8437658351304 0.210772549489551 no 705 0.199400135212983 1022 17122249
SGTC_2767 sibutramine 71.45 µM 0.842830089214546 0.211030625121167 no 706 0.199661738637971 983 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1115 galangin 695.678 nM 0.840045019272308 0.211799833453233 no 707 0.200441572624728 1068 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2518 prenyletin 46.28 µM 0.838561104281997 0.212210344898235 no 708 0.200857822508826 907 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_640 3381-0960 37.1 µM 0.838490436646558 0.212229906045409 no 709 0.200877658269986 1043 1745025
SGTC_2350 9023895 38.85 µM 0.837971919164932 0.212373466456039 no 710 0.201023237351209 971 2997209
SGTC_1209 2323-2347 50.3 µM 0.837514758169945 0.212500086333872 no 711 0.201151642453629 1003 5412760
SGTC_2691 st077356 60.2 µM 0.836619627492484 0.212748138342127 no 712 0.20140320469263 1008 2839272
SGTC_2382 9035899 200 µM 0.836462968484281 0.2127915679054 no 713 0.201447250594563 986 6462679
SGTC_1001 4048-4355 44.4 µM 0.835674987194653 0.213010093330166 no 714 0.201668885207138 959 21824233
SGTC_1945 st075991 56.6 µM 0.835253182619063 0.2131271232726 no 715 0.201787585700944 903 1084980
SGTC_2067 5224629 34.075 µM 0.83492851976117 0.213217226722526 no 716 0.201878977923657 990 2835000
SGTC_3186 9110464 49.47 µM 0.83383131941127 0.213521896295597 no 717 0.20218802190599 971 17018021
SGTC_1377 2944-0135 198 µM 0.833546471266952 0.213601034125139 no 718 0.20226830018529 1014 1894137
SGTC_355 1311-2252 105 µM 0.833123896996629 0.213718467140053 no 719 0.20238742870633 950 5338538
SGTC_3130 9127414 49.47 µM 0.831299200473756 0.214225980280678 no 720 0.202902313079107 994 1494646
SGTC_1839 st053978 48 µM 0.830476597442191 0.214455004603805 no 721 0.203134687010844 1007 3788398
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.830466004393256 0.21445795478668 no 722 0.203137680435798 1081 6708561
SGTC_2011 4012611 177 µM 0.83019698554534 0.214532884920974 no 723 0.203213709653803 1009 2049887
SGTC_793 0488-0545 106 µM 0.827708154703035 0.215226823277422 no 724 0.203917899890504 970 292548
SGTC_2345 9052315 157.45 µM 0.826188612737847 0.215651143259664 no 725 0.204348553402991 975 6469265
SGTC_1681 tripelennamine 100 µM 0.825887988279127 0.215735147678025 no 726 0.204433817517538 959 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2111 5486399 200 µM 0.825644765178305 0.21580312613789 no 727 0.204502816761265 1032 689674
SGTC_2089 5281248 129.67 µM 0.824246295234614 0.216194225537775 no 728 0.204899813433134 964 2737878
SGTC_2296 7971656 126.45 µM 0.8228128104461 0.216595542910023 no 729 0.205307225307829 1003 666570
SGTC_1939 st074455 53.6 µM 0.819393014028762 0.21755468515045 no 730 0.206281109709993 1003 1644229
SGTC_1126 isoteolin 1.0172 µM 0.818912141977956 0.217689750509846 no 731 0.206418270956932 1010 133323
SGTC_974 1326-0144 138 µM 0.818803634370496 0.217720234368168 no 732 0.20644922852923 1025 5411856
SGTC_1447 4239-0816 81.9 µM 0.817685231343552 0.218034579221374 no 733 0.206768472800876 956 1341554
SGTC_2865 9030313 51.95 µM 0.816791054681758 0.218286089816332 no 734 0.207023922553774 924 42562754
SGTC_1017 4239-0030 168 µM 0.816358896487207 0.218407705511943 no 735 0.20714744906899 990 1149593
SGTC_657 3534-0529 86.7 µM 0.815862075207256 0.218547566564196 no 736 0.20728951250134 1042 1049549
SGTC_2049 5262831 67.185 µM 0.815846537286125 0.218551941503764 no 737 0.207293956417043 1003 763417
SGTC_1318 1280-3875 124 µM 0.81165039449525 0.219735274062705 no 738 0.20849613290784 1007 373245
SGTC_3212 9128307 49.47 µM 0.81143971159017 0.219794784481885 no 739 0.208556600827037 886 27243542
SGTC_474 dl-dihydrosphingosine 5 µM 0.809381023464307 0.220376777260345 no 740 0.209148007062603 1059 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_427 1354-0053 47.3 µM 0.807974926400732 0.220774789220384 no 741 0.209552508184472 1003 6813657
SGTC_761 k216-0224 480 µM 0.806164130526215 0.221287961744355 no 742 0.210074108984585 1083 1340404
SGTC_774 k060-0086 136 µM 0.805752413277267 0.221404735936066 no 743 0.210192810719928 1096 5911235
SGTC_526 4469-0568 170 µM 0.803340897814937 0.222089414379625 no 744 0.21088886272137 1008 2901964
SGTC_2131 toluylene red 5.2905 µM 0.802141958937676 0.222430266903305 no 745 0.211235422983681 998 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3023 9089636 49.47 µM 0.799413903177947 0.223206950740903 no 746 0.212025225683062 1131 17249241
SGTC_2268 7933382 153.85 µM 0.79898104520801 0.223330328170901 no 747 0.212150701471957 1129 935025 YOR257W CDC31
SGTC_3280 9140961 49.47 µM 0.798881989985134 0.223358567319167 no 748 0.212179421455845 987 4901226
SGTC_3161 9100388 49.47 µM 0.798179105997146 0.223559007283821 no 749 0.212383280296202 1073 25236368
SGTC_3156 9099931 49.47 µM 0.797955436056134 0.223622812226315 no 750 0.212448175730347 1076 18111053
SGTC_235 0330-0087 5 mM 0.797651024492817 0.223709666467989 no 751 0.2125365160903 1087 46494818 YHR062C RPP1
SGTC_1825 st052143 62.6 µM 0.796604377460804 0.224008440490973 no 752 0.212840417152503 1010 674173
SGTC_1367 1812-0510 76.9 µM 0.796566424432263 0.224019278753345 no 753 0.212851441834977 1032 1142582 YDR527W RBA50
SGTC_794 k038-0031 316 µM 0.791872844052284 0.225361921037762 no 754 0.214217411307255 1067 6624242
SGTC_354 2783-3500 4.88 µM 0.790839849466369 0.225658029306971 no 755 0.214518726311838 1009 6740761
SGTC_1114 scopoletin 1.73284 µM 0.790731335741113 0.225689147576907 no 756 0.214550393060901 1063 5280460 A coumarin with genotoxic properties.
SGTC_3038 9091290 49.47 µM 0.790692542667335 0.225700272780291 no 757 0.214561714412911 1043 25236843
SGTC_1101 ebselen 5.29 µM 0.789698007088904 0.225985594830317 no 758 0.214852077753676 1136 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2117 5521686 200 µM 0.788797015226116 0.226244256100353 no 759 0.215115327151452 1040 803312
SGTC_2872 9044037 25.97 µM 0.788624662606291 0.226293755008006 no 760 0.215165706007595 1072 6465195
SGTC_2167 5876490 200 µM 0.786995970819148 0.226761810005149 no 761 0.215642112404169 1065 686534
SGTC_1835 st008666 49.2 µM 0.78686997645006 0.226798041135654 no 762 0.215678992313132 961 690455
SGTC_2561 acetosyringone 100 µM 0.783687715753788 0.227714219097537 no 763 0.216611686157538 1117 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2848 9016370 25.97 µM 0.78348238719347 0.227773404979192 no 764 0.216671946253674 1086 7894410
SGTC_2026 5148700 152 µM 0.782131808249292 0.228162924553998 no 765 0.217068557506249 1067 79838
SGTC_692 k241-0027 77.8 µM 0.782066690592242 0.228181714553644 no 766 0.217087690563609 1067 3600480
SGTC_901 1112-0062 60.1 µM 0.781659794993391 0.228299145852328 no 767 0.217207267865209 1103 1908457
SGTC_68 0986-0284 82.829 µM 0.781621475253452 0.228310206794846 no 768 0.217218531119474 914 423278 YIL048W NEO1
SGTC_2704 st078022 71.1 µM 0.781382918481846 0.228379072666844 no 769 0.217288657282035 1071 54697681
SGTC_1881 5652484 16 µM 0.777881212990063 0.229391276980768 no 770 0.218319522349058 1032 2255129
SGTC_897 1000-0139 31.4 µM 0.776491405580321 0.229793711229314 no 771 0.218729446693795 1067 6151020
SGTC_2999 9069765 71.4286 µM 0.776338860605963 0.229837906393155 no 772 0.218774466867927 1097 2097066
SGTC_3013 9080133 71.4286 µM 0.773468682780724 0.230670337762221 no 773 0.219622527954131 1137 17050193
SGTC_2397 5161689 200 µM 0.771317998998429 0.231295198209296 no 774 0.220259233158751 1067 2259942
SGTC_1420 4'-methoxyflavone 42 µM 0.770339150771133 0.231579905481288 no 775 0.220549369137951 1103 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_332 4112-0506 40.9 µM 0.77003085984302 0.231669615249057 no 776 0.220640793583816 1063 2790355
SGTC_405 ebelactone b 50 µM 0.769009872624953 0.231966851176253 no 777 0.220943724854729 1059 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1174 0739-0097 51.1 µM 0.768784607636827 0.23203246025522 no 778 0.221010593984165 1070 728447
SGTC_2965 9082772 38.63 µM 0.767254971132456 0.232478244466848 no 779 0.221464967524441 1123 16459634
SGTC_723 4182-0001 115 µM 0.765863218493151 0.232884258454762 no 780 0.221878846720401 1059 744821 YLR208W SEC13
SGTC_943 3253-1379 105 µM 0.764091455677281 0.233401701714278 no 781 0.222406371859107 1056 668464
SGTC_2937 9044753 11.33 µM 0.76187127067748 0.234051006101808 no 782 0.223068419094092 1130 6465530 YGL099W LSG1
SGTC_2651 TUB2.036 5 µM 0.761622538247356 0.234123811432579 no 783 0.223142659609682 1215 15992207 YFL037W TUB2
SGTC_1707 st032323 6.317 µM 0.761597807696296 0.234131050884324 no 784 0.223150041839995 1050 3132057 YMR211W DML1
SGTC_2766 oltipraz 83.91 µM 0.761413666814906 0.234184958919332 no 785 0.223205013462445 1058 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_203 k066-0004 30.888 µM 0.760850162580159 0.234349969892985 no 786 0.223373284401695 1190 6795412
SGTC_3134 9127454 49.47 µM 0.759923159716584 0.234621564130993 no 787 0.22365025854853 1136 24262820
SGTC_1886 st057356 49.9 µM 0.758436964201897 0.235057354220303 no 788 0.224094718090807 1058 24207747
SGTC_1956 st077085 54 µM 0.757716806598078 0.235268683356106 no 789 0.224310267736567 1137 24208685
SGTC_485 niflumic acid 177 µM 0.756900998924722 0.235508207526037 no 790 0.224554588435119 1068 4488 A COX2 inhibitor.
SGTC_2129 girgensonine 121.053 µM 0.755454967378504 0.235933098191314 no 791 0.224988021369552 1133 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1534 6-azauridine 81.6 µM 0.754959377915051 0.236078815499173 no 792 0.225136678187614 1166 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_129 0088-0017 176.636 µM 0.753091182636187 0.236628563208632 no 793 0.225697561281346 1051 182446
SGTC_2964 9083345 53.42 µM 0.752768375709947 0.236723625856762 no 794 0.225794556747007 1088 17741579
SGTC_2405 ticlatone 3.52 µM 0.752644860274251 0.236760005180738 no 795 0.225831676304015 1068 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1327 1436-0082 2.18 µM 0.752521785656728 0.236796257727423 no 796 0.225868666816316 1059 15992205
SGTC_1874 staurosporine 7.6 µM 0.751140443111888 0.237203351800682 no 797 0.226284069172605 1130 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2327 6189656 200 µM 0.749907025252645 0.237567175799594 no 798 0.226655351529696 1120 5349088
SGTC_2525 harmine 47.85 µM 0.74961344787228 0.237653818069679 no 799 0.226743774564506 1063 5280953 A monoamine oxidase inhibitor
SGTC_1118 chelidonine 707.474 nM 0.747916129905987 0.238155080173351 no 800 0.227255373851921 1158 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.747650429731965 0.238233600748815 no 801 0.227335519057281 1102 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2253 7938677 135.83 µM 0.747459031677088 0.238290172108383 no 802 0.22739326180407 1112 2301972
SGTC_1636 st007707 68.9 µM 0.747343686338663 0.238324268184618 no 803 0.227428064249044 1135 403051
SGTC_1997 st073024 93.8 µM 0.743166055585703 0.239560974865159 no 804 0.228690575776107 1127 686268
SGTC_2569 tetrandrine 100 µM 0.742565596501415 0.23973901666672 no 805 0.228872361953232 1047 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2331 7980721 200 µM 0.741982740540719 0.239911908010291 no 806 0.229048896410024 1119 2981221
SGTC_3340 9146634 11.102 µM 0.741873296454772 0.239944379762112 no 807 0.229082053171518 1129 4907387
SGTC_1999 st074831 12.5 µM 0.741431502552239 0.240075483130572 no 808 0.229215924728698 1082 17112523
SGTC_1562 morin hydrate 59.1 µM 0.740384404863522 0.240386367711641 no 809 0.229533389437326 1116 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1617 st002906 78 µM 0.738468120809855 0.240955882229974 no 810 0.230115016234095 1126 5150859
SGTC_1876 myriocin 605 nM 0.737139852452693 0.241351070270732 no 811 0.230518653031691 1146 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1172 0370-0043 85 µM 0.736792114391991 0.241454587860631 no 812 0.230624389677729 1147 376585
SGTC_2022 5136654 200 µM 0.736758812610764 0.241464502680096 no 813 0.230634517165725 1110 1713771
SGTC_694 1315-0438 43.2 µM 0.736104739599178 0.241659282300419 no 814 0.230833479307034 1047 6793154
SGTC_700 3453-2283 142 µM 0.734547925009574 0.24212323670176 no 815 0.231307431328409 1168 565664
SGTC_419 nsc-638432 893 µM 0.733289858221823 0.242498512260393 no 816 0.231690829665337 1108 368090
SGTC_460 trequinsin 123 µM 0.73312751674357 0.242546960919269 no 817 0.231740329334391 1185 5537 A vasodilator.
SGTC_1230 0170-0365 3.77 µM 0.732440173502538 0.24275214745565 no 818 0.231949972980568 1232 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_633 0437-0093 97.7 µM 0.731953145940793 0.242897592366131 no 819 0.232098583096428 1173 2831118
SGTC_1061 3448-9325 110 µM 0.731436479141518 0.243051940204727 no 820 0.232256295160343 1122 723482
SGTC_547 1120-0019 610 nM 0.73118120973283 0.243128218368307 no 821 0.232334237915161 1094 3676939
SGTC_2015 5119600 184 µM 0.730887310901429 0.243216055586281 no 822 0.232423993613579 1128 2828786
SGTC_248 streptozotocin 5.23457 mM 0.72989867333502 0.243511654473842 no 823 0.232726061652393 1185 5300 DNA alkylating agent.
SGTC_2750 bromebric acid 70.15 µM 0.728955297795433 0.243793901027122 no 824 0.233014503653117 1156 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1607 st000305 50.6 µM 0.728158561908417 0.244032412240645 no 825 0.233258264374561 1139 5457690
SGTC_1658 st012944 20 µM 0.727679072223955 0.244176013133564 no 826 0.233405032056424 1095 24207260
SGTC_1157 4092-0394 27.6 µM 0.726495151548014 0.244530776955767 no 827 0.233767639353221 1198 3659885
SGTC_2727 riluzole 51.77 µM 0.726389637546906 0.244562407873502 no 828 0.233799970977992 1148 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.7259915469457 0.244681767051931 no 829 0.23392197630358 1162 6312947
SGTC_2675 theaflavin digallate 100 µM 0.725340828051334 0.244876939086346 no 830 0.234121482140504 1130 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1273 0849-0096 14.1 µM 0.725135363441846 0.244938582090953 no 831 0.234184495711807 1146 5286025
SGTC_1583 clindamycin 39.6 µM 0.724545677680379 0.245115544573864 no 832 0.234365397514435 1089 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2723 salbutamol 83.58 µM 0.723104552331339 0.245548310087842 no 833 0.234807826340648 1105 9884233 β2-adrenoceptor agonist
SGTC_663 1486-0733 13.9 µM 0.722861706646427 0.245621276289921 no 834 0.234882425956888 1136 722445 YPR165W RHO1
SGTC_444 curcumin 90.4 µM 0.720478778296838 0.246337876029386 no 835 0.235615130684394 1102 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_207 4185-0010 4.486 µM 0.720364966721635 0.246372129728319 no 836 0.235650157077329 1216 3761753
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.719899294065835 0.246512309116475 no 837 0.235793501351962 1167 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1664 st014217 9.02 µM 0.718459647525585 0.24694594970155 no 838 0.236236960095976 1228 3982782
SGTC_2709 st078560 56 µM 0.717971050025105 0.247093214459685 no 839 0.236387568612065 1168 17250903
SGTC_1281 0884-0031 11.8 µM 0.717344740818017 0.247282054623108 no 840 0.236580703572545 1195 1548255
SGTC_3189 9110682 49.47 µM 0.71611161348158 0.247654083542391 no 841 0.236961216658251 1185 17122418
SGTC_1413 3910-0535 34.4 µM 0.715226633535129 0.247921262114533 no 842 0.237234507146523 1178 2876951
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.715037324212615 0.247978435234603 no 843 0.237292990192318 1010 4000243
SGTC_523 1934-0222 13.7 µM 0.714464493726948 0.248151478044195 no 844 0.23747000207526 1180 1361595
SGTC_2867 9039098 71.43 µM 0.714006872708689 0.248289764203527 no 845 0.237611464838827 1156 6463460
SGTC_836 0330-0104 1.35 µM 0.713330573397108 0.248494206843632 no 846 0.237820611488916 1186 46494820
SGTC_2822 7994718 71.43 µM 0.712833204058091 0.248644616874044 no 847 0.237974488162188 1115 1018011
SGTC_107 0358-0022 2.6945 µM 0.712710833374869 0.248681630563879 no 848 0.238012355703538 1113 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_611 3453-1652 23.7 µM 0.71259208160291 0.248717552440237 no 849 0.238049106532462 1179 1560575
SGTC_968 1309-0633 340 µM 0.712507851042172 0.248743033480601 no 850 0.238075175758741 1162 3761976
SGTC_584 0986-0246 15.4 µM 0.710577386924741 0.249327409389882 no 851 0.238673080035699 1273 53315 YDR232W HEM1
SGTC_2112 5488546 200 µM 0.710085464952448 0.249476436996446 no 852 0.238825569606493 1165 600757
SGTC_623 k072-0108 16.9 µM 0.70885217086597 0.249850271056511 no 853 0.239208109299791 1142 5382803
SGTC_1355 1499-0035 1.68 µM 0.707866911158823 0.250149134888243 no 854 0.239513954806821 1185 1548538
SGTC_581 0958-0271 211 µM 0.707787023138267 0.250173376035335 no 855 0.239538763096784 1202 4591145
SGTC_270 tamoxifen 5.46 µM 0.707604438496802 0.250228784027629 no 856 0.239595467887343 1263 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1208 2323-2347 50.3 µM 0.707521639368746 0.25025391278417 no 857 0.239621184990685 1177 5412760
SGTC_669 0108-0021 26.2 µM 0.706394856208728 0.250596013842545 no 858 0.239971309400943 1248 17201
SGTC_902 1120-0002 2.07 µM 0.704705678101819 0.251109326555097 no 859 0.240496708509049 1179 3280475
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.699539511900917 0.252682682652958 no 860 0.242107464615316 1212 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1131 3454-3128 32.3 µM 0.699242276843513 0.25277336328428 no 861 0.242200316995129 1223 710982
SGTC_247 mechlorethamine 29.705 µM 0.697920066693743 0.253176951412761 no 862 0.242613592136917 1126 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.69537339773229 0.253955244228395 no 863 0.24341066371771 1191 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3198 9112019 49.47 µM 0.693538847354628 0.25451668199453 no 864 0.24398572777915 1234 45595555
SGTC_1868 st057644 42.7 µM 0.693391953920785 0.254561664720594 no 865 0.244031805138982 1220 688665
SGTC_1694 st024011 44.9 µM 0.692363761256638 0.254876641569803 no 866 0.244354458779037 1255 2787533
SGTC_749 1000-0129 128 µM 0.691656620527917 0.255093385597149 no 867 0.24457649756994 1255 708470
SGTC_2979 9012552 45.46 µM 0.690210514889349 0.255536927992398 no 868 0.245030905936487 1239 17100905
SGTC_1899 st063254 59.6 µM 0.690034250800993 0.255591018377362 no 869 0.245086324265458 1153 3093813
SGTC_3275 9138069 49.47 µM 0.688565163952188 0.2560420714505 no 870 0.245548474800654 1207 17617007
SGTC_128 0906-2981 13.371 µM 0.68802708331757 0.25620738193696 no 871 0.24571786316814 1185 6740226
SGTC_202 3594-0513 34.79 µM 0.687728974162271 0.256298991731551 no 872 0.245811735255801 1186 708429
SGTC_3240 9133527 49.47 µM 0.687023764074318 0.256515772755797 no 873 0.246033876646675 1193 17617455
SGTC_2142 5622915 118.518 µM 0.686060929765622 0.256811901417194 no 874 0.246337343560418 1193 5322196
SGTC_1109 tnp00067 928.257 nM 0.685351278353465 0.25703027516626 no 875 0.246561140451836 1203 676295
SGTC_219 mitoxanthrone 164.414 µM 0.683917965128977 0.257471628308459 no 876 0.247013484528665 1184 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1285 0929-0069 65.5 µM 0.683484686199803 0.257605123226065 no 877 0.247150311809978 1213 1206237
SGTC_807 1315-0151 48 µM 0.682261444802675 0.257982202530019 no 878 0.247536823888696 1250 4011080
SGTC_991 3996-0057 64.7 µM 0.682084606777563 0.258036738718452 no 879 0.247592726754686 1198 715343
SGTC_2113 5491891 107.031 µM 0.680196155583888 0.258619502682172 no 880 0.248190133128845 1235 789979
SGTC_1305 1181-0477 144 µM 0.679486137656068 0.258838785814083 no 881 0.248414944046595 1221 6252086
SGTC_1730 st033808 45.1 µM 0.678506723037749 0.259141427682809 no 882 0.248725231281902 1218 1045166
SGTC_517 1365-0151 113 µM 0.677298840965455 0.259514918402779 no 883 0.249108183067265 1259 768657
SGTC_1203 3992-3522 103 µM 0.677123847678108 0.259569051339996 no 884 0.249163689642078 1354 5322312
SGTC_2986 9022445 71.43 µM 0.67570494864881 0.260008192924779 no 885 0.249613996708849 1195 6459286
SGTC_743 1275-0778 158 µM 0.674924044186871 0.260250041981143 no 886 0.249862011759624 1227 2849257 YMR203W TOM40
SGTC_646 4092-0839 27.3 µM 0.673711904032758 0.260625675845711 no 887 0.250247246116002 1266 877796
SGTC_3081 9117243 49.47 µM 0.672229773907377 0.261085356685029 no 888 0.25071871454801 1254 45595589
SGTC_2916 7875993 68.79 µM 0.670553425923542 0.261605775761992 no 889 0.251252530408711 1227 1299250
SGTC_1381 2324-0066 62.1 µM 0.670186429827239 0.261719780007681 no 890 0.251369476696987 1234 10885928
SGTC_1045 1348-1485 165 µM 0.669215762033278 0.262021432602669 no 891 0.251678926517513 1262 6810614
SGTC_1469 k284-2957 126 µM 0.667038885770015 0.262698583779772 no 892 0.252373647651127 1259 23884841
SGTC_2407 paclitaxel 400 µM 0.666655266844435 0.262818007125525 no 893 0.252496179211236 1315 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_605 1315-0399 119 µM 0.664801237156718 0.263395571071543 no 894 0.253088815632331 1288 24020461
SGTC_2936 9038235 15.59 µM 0.664063304827257 0.263625630553745 no 895 0.253324897456769 1244 4749415
SGTC_1684 st024538 14.6195 µM 0.663001218344277 0.263956928945724 no 896 0.253664886891212 1226 6732859
SGTC_2293 7624732 200 µM 0.66202861888181 0.264260499530216 no 897 0.253976440300301 1221 894453
SGTC_3207 9114163 49.47 µM 0.66130733710602 0.264485742858555 no 898 0.254207618553419 1300 849233
SGTC_899 1083-0020 478 µM 0.660675166169342 0.264683238780679 no 899 0.254410326562982 1295 767123
SGTC_2768 sulfasalazine 50.2 µM 0.66049540054784 0.264739412880804 no 900 0.254467984557325 1299 5384001 An antioxidant and salicylic acid derivative.
SGTC_452 diindolylmethane 8 µM 0.660026367282349 0.264886007382159 no 901 0.254618454438442 1232 3071 Inhibits expression of several cancer promoting factors.
SGTC_1024 4507-0395 26 µM 0.659678149041879 0.264994868302154 no 902 0.254730195961425 1280 4201836
SGTC_1751 st044839 27.194 µM 0.65780039749996 0.26558228755369 no 903 0.255333199473035 1255 5291326
SGTC_1398 3558-0053 112 µM 0.657606096159494 0.265643108757776 no 904 0.255395638152139 1173 4532369
SGTC_1106 tegaserod maleate 11.7 µM 0.657407696551777 0.265705220110101 no 905 0.255459402040955 1277 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2141 5621638 7.665 µM 0.65636981289707 0.266030261873426 no 906 0.255793104246352 1273 2856238
SGTC_2708 st078559 56 µM 0.654882872446026 0.266496288809888 no 907 0.256271584222532 1188 17250902
SGTC_2597 laccaic acid a 100 µM 0.654268979553076 0.266688811376349 no 908 0.25646926373746 1225 5491415 A textile dye.
SGTC_2795 7780010 54.55 µM 0.652787071302607 0.267153841218855 no 909 0.256946779833835 1255 953673
SGTC_3239 9133757 49.47 µM 0.652326454959562 0.267298468156388 no 910 0.257095298665981 1263 17036923
SGTC_1511 0906-3109 28.5 µM 0.652256947866947 0.267320295818407 no 911 0.257117714061757 1303 2882180
SGTC_2650 prasterone 100 µM 0.651726616980905 0.267486867897111 no 912 0.257288774330451 1235 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3301 9125354 19.7965 µM 0.648792454250704 0.268409406454982 no 913 0.258236267709092 1253 41905162
SGTC_3324 9138759 60.749 µM 0.647526419972415 0.268807957479429 no 914 0.258645650557752 1281 45595710
SGTC_1749 st037932 54.2 µM 0.647173662983891 0.268919059258952 no 915 0.25875977732543 1264 594497
SGTC_2773 thioridazine 9.09 µM 0.64712332825676 0.268934914198485 no 916 0.258776064144232 1283 5452 An antipsychotic.
SGTC_595 3909-8003 73.7 µM 0.64692812175667 0.268996406747764 no 917 0.258839232172702 1305 699517
SGTC_2928 9011484 9.79 µM 0.646756531981614 0.269050465553988 no 918 0.258894764513467 1264 2994751
SGTC_1489 4065-0444 182 µM 0.646753148518629 0.269051531557922 no 919 0.258895859580186 1242 2877968
SGTC_32 0928-0142 34.1 µM 0.646748975116765 0.269052846445273 no 920 0.258897210316007 1239 2244242
SGTC_1071 trifluoperazine 6.31 µM 0.646521426174583 0.269124543733824 no 921 0.258970862829504 1316 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_978 1416-0512 87.4 µM 0.645529416446308 0.26943722320485 no 922 0.259292080801888 1296 6814003
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.645162585741093 0.269552893608976 no 923 0.259410914637852 1308 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_927 2425-1185 123 µM 0.643353585179839 0.27012367798618 no 924 0.25999734676863 1257 730375
SGTC_1059 3448-6867 171 µM 0.643325189883453 0.270132642221059 no 925 0.260006557250731 1248 3934407
SGTC_2128 5255449 168.493 µM 0.642690647274729 0.270333002551967 no 926 0.260212425480624 1268 736008
SGTC_2536 dehydroabietamide 32.04 µM 0.641975348257274 0.27055895120264 no 927 0.260444594648021 1328 3983547
SGTC_2173 5763948 167 µM 0.641433145309914 0.270730285103296 no 928 0.26062065197481 1286 2867177
SGTC_2483 5729050 27.16 µM 0.640540973713926 0.271012325510818 no 929 0.260910479999362 1333 2865180
SGTC_2524 avocatin b 10.57 µM 0.634286591831247 0.272993616611496 no 930 0.262946902624229 1232 6710748
SGTC_2428 5615643 7.78 µM 0.632246911360447 0.273641305044464 no 931 0.263612773929298 1308 2253075
SGTC_1041 0206-0046 107 µM 0.631525004789798 0.273870724222423 no 932 0.26384865252525 1316 50494
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.629049408366141 0.274658180882884 no 933 0.264658355074213 1271 688667
SGTC_643 k048-0106 28.4 µM 0.628754709434681 0.274751995297839 no 934 0.264754827461823 1330 6763920
SGTC_2889 9059656 51.95 µM 0.628159887085746 0.274941399071067 no 935 0.264949602444593 1354 3949838
SGTC_863 0466-0191 129 µM 0.626220510623441 0.275559383243236 no 936 0.2655851579246 1296 765160 YPR165W RHO1
SGTC_378 3970-0959 8.33 µM 0.625052351436519 0.275931947647155 no 937 0.265968349631649 1310 6615653
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.624258666128274 0.276185221092949 no 938 0.266228862235656 1267 390807
SGTC_1242 0402-0103 60.1 µM 0.622423400869882 0.276771310400358 no 939 0.266831748561128 1273 432868
SGTC_3202 9113761 49.47 µM 0.622110322093745 0.276871352455609 no 940 0.266934664062928 1371 4798415
SGTC_971 1315-0384 26.7 µM 0.621423759081337 0.277090800672655 no 941 0.267160421771291 1292 6769120
SGTC_1479 0549-0158 134 µM 0.620789839019828 0.277293498014882 no 942 0.267368954810295 1330 5440202
SGTC_1472 k841-0093 193 µM 0.618577350936284 0.278001513668632 no 943 0.268097413161303 1362 X1472
SGTC_1500 4488-1866 171 µM 0.617106225626331 0.278472774464647 no 944 0.268582331293579 1383 2900003
SGTC_710 3448-4187 58 µM 0.615583659446942 0.27896092335202 no 945 0.269084669358443 1346 3946412
SGTC_2638 epoxomicin 18 µM 0.613176840835934 0.279733419824878 no 946 0.269879708101322 1331 9915668 A protesome inhibitor.
SGTC_2746 daunorubicin 9.88 µM 0.611333210884351 0.28032585555266 no 947 0.270489504407362 1251 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.610907697582228 0.280462677101938 no 948 0.270630344276782 1368 4114 Related to psoralen; DNA damaging agent.
SGTC_3096 9117468 49.47 µM 0.610127451044145 0.280713645196025 no 949 0.270888691767204 1238 41316311
SGTC_3231 9132313 49.47 µM 0.609712436811648 0.280847179717576 no 950 0.271026157285291 1339 4905967
SGTC_2420 aureobasidin a 50 nM 0.609605966714916 0.280881442367705 no 951 0.271061429074053 1453 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1677 st019204 53.9 µM 0.606254346751771 0.281961043403269 no 952 0.272172934608903 1291 3945625
SGTC_1105 epirubicin 18.1 µM 0.606018049282355 0.282037233303371 no 953 0.272251383896251 1267 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1986 st071812 45 µM 0.605258485147929 0.282282208331116 no 954 0.272503630540948 1331 11838594
SGTC_3069 9117009 49.47 µM 0.60504003763076 0.282352681093205 no 955 0.272576197117729 1239 41904981
SGTC_174 3553-0389 74.3 µM 0.603597837732265 0.282818157573223 no 956 0.273055525373535 1346 738071
SGTC_1953 st076800 12.1 µM 0.600583885068972 0.283792112639853 no 957 0.274058586967961 1303 297591
SGTC_1798 st045719 60.953 µM 0.59943811575441 0.28416278739508 no 958 0.274440382959466 1275 3980186
SGTC_3158 9100007 49.47 µM 0.598533083770218 0.28445574333014 no 959 0.274742145330051 1328 19297233
SGTC_2370 9071495 200 µM 0.597073703501944 0.284928443706399 no 960 0.275229086888087 1301 21791103
SGTC_2249 haloperidol 116.36 µM 0.596265858176039 0.285190269746809 no 961 0.275498817748202 1338 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1430 4049-0248 69.1 µM 0.595692485461801 0.285376171777668 no 962 0.275690339586025 1418 22774488
SGTC_1750 st081859 2.357 µM 0.595500375142325 0.285438471739482 no 963 0.27575452421125 1344 5291695
SGTC_3228 9131799 49.47 µM 0.594263156647385 0.285839847658749 no 964 0.27616805842696 1372 17015818
SGTC_3109 9122853 49.47 µM 0.594028388041648 0.285916041099346 no 965 0.276246563028273 1418 1234709
SGTC_1622 st003707 19.4 µM 0.592104271025919 0.286540871015685 no 966 0.276890383540504 1386 10140899
SGTC_1073 triclabendazole 3.09 µM 0.59054509819869 0.287047665100305 no 967 0.277412630030907 1385 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_959 1222-0044 107 µM 0.590451922935998 0.287077964257368 no 968 0.277443854419832 1350 6083612
SGTC_805 3852-0218 479 µM 0.590150190830828 0.287176093271726 no 969 0.277544981035295 1309 6615355
SGTC_502 l-744,832 89.3 µM 0.589163759932327 0.287497010102234 no 970 0.277875712592832 1329 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.589095043637221 0.28751937197927 no 971 0.277898759028069 1386 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_51 1013-0126 23.419 µM 0.588239386705291 0.287797891455221 no 972 0.278185811898724 1471 1627850
SGTC_771 0250-0039 27.3 µM 0.587757183022752 0.287954906654941 no 973 0.278347643625475 1367 3005115
SGTC_2523 spermine 47.74 µM 0.587596858461421 0.288007120508208 no 974 0.278401460097654 1336 1103 A DNA binding polyamine.
SGTC_1456 k015-0012 13 µM 0.585914346488273 0.288555343552646 no 975 0.278966537941691 1423 2989616
SGTC_1726 st035556 14.5795 µM 0.584573655908078 0.288992540548221 no 976 0.279417212854596 1457 5919439
SGTC_435 c-PAF 6.7 µM 0.584077385480887 0.28915445250884 no 977 0.279584124448967 1329 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2193 5925765 200 µM 0.583565989197809 0.289321344002837 no 978 0.279756173974242 1378 877370
SGTC_2462 5162487 171.77 µM 0.583024420335417 0.28949813149424 no 979 0.279938430474841 1339 2259986
SGTC_3127 9126946 49.47 µM 0.582487697889262 0.289673386979032 no 980 0.280119112776124 1317 27243249
SGTC_2698 st077697 67.5 µM 0.581575705518326 0.289971293146282 no 981 0.280426255524464 1301 3154499
SGTC_1571 st070080 73.4 µM 0.581407054006765 0.290026399610918 no 982 0.28048307220067 1459 4315245
SGTC_2285 7945142 200 µM 0.580926813766757 0.290183343809822 no 983 0.280644889907736 1366 2970608
SGTC_2665 lovastatin 100 µM 0.580675874928607 0.290265367329664 no 984 0.280729462107193 1343 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3117 9124945 49.47 µM 0.580332270474338 0.290377697754796 no 985 0.280845284755573 1271 17592065
SGTC_1167 k781-0610 148 µM 0.57979376912714 0.290553784384599 no 986 0.281026849971154 1399 4525169
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.576026840381529 0.291786941907082 no 987 0.282298519880434 1329 1241132 A phosphatase inhibitor.
SGTC_737 1950-0117 57.9 µM 0.573200043163223 0.292713932641211 no 988 0.28325462758159 1356 5393513
SGTC_1817 st052116 64.4 µM 0.571622030040091 0.293232004156999 no 989 0.283789033671156 1419 4361398
SGTC_3146 9095609 49.47 µM 0.571494699455491 0.293273826106281 no 990 0.283832176176628 1438 17173999
SGTC_394 menadione 8.33 µM 0.571274175680991 0.29334626405877 no 991 0.283906902086743 1373 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2969 9091408 28.7 µM 0.570037484727313 0.29375264754103 no 992 0.284326137199725 1343 4286311
SGTC_19 0279-0214 38.434 µM 0.569569232004044 0.2939065859375 no 993 0.284484950878609 1423 3566274 YBR002C RER2
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.568040298507851 0.294409483452898 no 994 0.285003802360644 1352 140250 A respiratory chain inhibitor.
SGTC_105 0111-0055 734.78 µM 0.567288784327677 0.294656817380356 no 995 0.285258997884925 1364 5179370
SGTC_1892 st058411 7.36 µM 0.565796935592492 0.295148089621586 no 996 0.285765914939336 1451 3934738
SGTC_311 1315-0136 58 µM 0.565499721245432 0.295246008627503 no 997 0.285866956915324 1440 6759207
SGTC_56 0957-0365 83.25 µM 0.563188067478753 0.296008106394411 no 998 0.286653413691009 1345 6752360
SGTC_2443 5493264 126.67 µM 0.56315063344757 0.296020454938974 no 999 0.28666615770695 1457 5340055
SGTC_412 gemfibrozil 100 µM 0.563091527522093 0.296039952977343 no 1000 0.286686280234725 1375 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_3147 9097027 49.47 µM 0.562916337030304 0.296097748800167 no 1001 0.286745927521304 1484 25236841
SGTC_1251 0490-5699 265 µM 0.562437254075583 0.296255826013305 no 1002 0.286909071421997 1434 3883818
SGTC_685 1278-0033 54.9 µM 0.562309250983487 0.296298068198164 no 1003 0.28695266823491 1463 3590572
SGTC_2913 7966556 36.57 µM 0.561732768326968 0.296488346941055 no 1004 0.287149052427098 1416 2976516
SGTC_2178 5812956 200 µM 0.559727654344158 0.297150607510947 no 1005 0.287832608270124 1391 5403383
SGTC_1321 1326-2144 215 µM 0.559028155874607 0.297381800897149 no 1006 0.288071252350522 1427 3513030
SGTC_626 0214-0009 33 µM 0.558897016846199 0.297425153204308 no 1007 0.288116002730053 1482 3437874
SGTC_1810 st050138 53 µM 0.558830895404018 0.297447012910308 no 1008 0.288138567505689 1390 3444541
SGTC_1314 1222-0010 41.1 µM 0.558560620374281 0.297536373288295 no 1009 0.288230810935513 1408 3526027
SGTC_97 0535-0701 19.132 µM 0.557989068711045 0.297725384381343 no 1010 0.288425924336862 1342 2832013 YGL099W LSG1
SGTC_1733 st037357 54.9 µM 0.557812636823316 0.297783741147776 no 1011 0.288486166330738 1336 1272339 YGL099W LSG1
SGTC_26 0302-0163 425.158 µM 0.557548903248472 0.297870983624278 no 1012 0.288576228207308 1406 3100915
SGTC_2348 9022543 33.42 µM 0.557298208952099 0.2979539235397 no 1013 0.288661849603604 1424 3162678 YDL140C RPO21
SGTC_1033 k072-0102 21.3 µM 0.556694775910432 0.298153606997232 no 1014 0.28886799340585 1437 5965931
SGTC_2073 5212005 126 µM 0.555333241509477 0.29860437935981 no 1015 0.289333372906535 1305 691789
SGTC_679 0422-0091 41.4 µM 0.554729651985392 0.298804312914424 no 1016 0.289539795578811 1387 627384 YHR062C RPP1
SGTC_2366 9070441 60.58 µM 0.554203073977868 0.298978786774064 no 1017 0.289719937405735 1353 6837235
SGTC_1390 3413-2614 145 µM 0.553426834227721 0.299236066708652 no 1018 0.28998558414454 1406 3421432
SGTC_416 estradiol valerate 100 µM 0.553155295097553 0.299326090409175 no 1019 0.290078537909483 1411 13791 A steroid.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.551349399163712 0.299925113563301 no 1020 0.290697090461283 1405 165521
SGTC_3308 9128332 17.569 µM 0.55050859537997 0.300204196645541 no 1021 0.290985291528322 1504 17332805 YDL196W YDL196W
SGTC_2955 9076254 12.21 µM 0.547430387067948 0.301226928610457 no 1022 0.29204154179342 1397 16459619
SGTC_932 2857-0803 154 µM 0.546679978526224 0.301476488912172 no 1023 0.292299305820935 1543 674898
SGTC_1140 3229-1848 2.98 µM 0.546605642688551 0.301501215542126 no 1024 0.292324845810916 1423 2849525
SGTC_1483 3453-0561 55.9 µM 0.546439376678719 0.301556524579572 no 1025 0.292381974533566 1441 4546991
SGTC_3316 9136639 10.545 µM 0.546174326596834 0.30164470396126 no 1026 0.292473056030191 1477 4903665
SGTC_2444 5485484 36.41 µM 0.543384190482798 0.302573655633089 no 1027 0.293432654252514 1520 6790631
SGTC_1624 st003710 6.25 µM 0.543012325806502 0.302697561532831 no 1028 0.293560657969647 1501 24207033
SGTC_1224 0823-0416 294 µM 0.542627274590092 0.302825885157482 no 1029 0.293693228014981 1488 3598164
SGTC_1144 3486-0183 12.5 µM 0.540234750085368 0.303623772205348 no 1030 0.294517575291516 1414 6744069
SGTC_1689 st020265 53.493 µM 0.539993008581287 0.303704443170205 no 1031 0.294600926987277 1489 5758320 YPR016C TIF6
SGTC_363 0455-0021 3.06 µM 0.539429308539011 0.303892591279418 no 1032 0.294795331219048 1452 4597466
SGTC_1010 4112-3296 15.2 µM 0.53898623757232 0.30404051308346 no 1033 0.294948175388589 1481 704384
SGTC_1491 4138-0063 26.5 µM 0.538359914349559 0.304249669444245 no 1034 0.295164297522346 1416 23883227
SGTC_3292 9120825 59.784 µM 0.535962754431907 0.30505077593015 no 1035 0.295992145962903 1489 24824900
SGTC_2048 5246248 200 µM 0.535936932730956 0.305059410377486 no 1036 0.296001069171677 1443 677046
SGTC_246 cycloheximide 667 µM 0.534123357737515 0.30566611796189 no 1037 0.296628095199575 1366 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2493 resveratrol 26.09 µM 0.533634430118764 0.305829773683973 no 1038 0.296797241256288 1390 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_845 0330-0138 4.51 µM 0.533354839363119 0.305923376802529 no 1039 0.296893986401198 1489 9039800
SGTC_2732 terfenadine 20 µM 0.53287966201582 0.306082488686365 no 1040 0.297058442318713 1434 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2824 7998404 51.95 µM 0.532586530398866 0.306180661288145 no 1041 0.297159914116048 1453 837851
SGTC_2645 abamectin 100 µM 0.531289358664656 0.306615263611864 no 1042 0.297609139177431 1429 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2174 5790901 200 µM 0.530545979510743 0.306864446841105 no 1043 0.297866719313702 1430 786020
SGTC_1604 st002052 72.4 µM 0.52991599716212 0.307075688958077 no 1044 0.298085087115502 1458 6254834 YHR062C RPP1
SGTC_2945 9067681 61.76 µM 0.529870978465477 0.307090786825591 no 1045 0.298100694525432 1480 16456930
SGTC_1630 st005209 31.3 µM 0.529710692546481 0.30714454438153 no 1046 0.2981562666387 1451 3367314
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.52828747911732 0.307622051078044 no 1047 0.298649910318911 1438 5106787 A p450 inhibitor.
SGTC_937 3122-0005 46.7 µM 0.526933977088748 0.308076471281133 no 1048 0.299119718966644 1460 759535
SGTC_2829 7992743 58.44 µM 0.526603326242738 0.308187527649413 no 1049 0.299234540820465 1497 16462845
SGTC_1019 4262-0212 3.4 µM 0.525829321458676 0.308447562859382 no 1050 0.299503399985792 1478 4677213
SGTC_1467 k284-1082 293 µM 0.525786975615614 0.308461792174014 no 1051 0.299518112443849 1519 3334705
SGTC_1497 4476-2978 41.3 µM 0.523429347433635 0.309254470545577 no 1052 0.300337752938028 1458 1528379
SGTC_2291 7917025 104.35 µM 0.523118980797614 0.309358887842244 no 1053 0.30044572881426 1391 2964612
SGTC_2311 7694451 200 µM 0.522613055137918 0.309529130471753 no 1054 0.300621776828069 1511 2163142
SGTC_1513 0337-0559 19 µM 0.522188703451607 0.309671955204404 no 1055 0.300769475276154 1380 775073
SGTC_3315 9136395 68.55 µM 0.520571873872511 0.310216397388353 no 1056 0.30133252342451 1498 16876844
SGTC_650 1328-0195 38 µM 0.519623625433022 0.310535899016411 no 1057 0.30166296409863 1448 2780821
SGTC_139 0099-0334 718.624 µM 0.516309524113663 0.311653670011203 no 1058 0.302819122674633 1473 97690
SGTC_1693 xanthone 101.9 µM 0.514792738386172 0.31216582764794 no 1059 0.303348930122057 1496 7020 An insecticide.
SGTC_2653 dihydrofissinolide 100 µM 0.513292536572919 0.312672742900964 no 1060 0.303873351963533 1484 6857746
SGTC_1848 st056003 16.4 µM 0.512146988455788 0.313060060159142 no 1061 0.304274070451366 1490 146492
SGTC_40 0327-0103 19.753 µM 0.510955707505638 0.313463058899576 no 1062 0.304691035944542 1429 409036
SGTC_2707 st078556 66.6 µM 0.50913682766182 0.314078797892829 no 1063 0.305328159682253 1518 17250899
SGTC_3002 9075603 71.4286 µM 0.508493879125261 0.314296576984008 no 1064 0.305553515283972 1450 20105405
SGTC_1178 0988-0033 191 µM 0.506651576431937 0.314920958371368 no 1065 0.306199656355393 1490 5392207
SGTC_2520 obtusaquinone 4.71 µM 0.505944795121071 0.315160636743662 no 1066 0.306447702258709 1560 5967872
SGTC_366 0181-0206 4.31 µM 0.505724223095605 0.315235451412834 no 1067 0.306525130491408 1615 274874
SGTC_1422 4031-0024 15.5 µM 0.505499882651939 0.315311552045472 no 1068 0.306603890426299 1430 782427
SGTC_3083 9117465 49.47 µM 0.504766370394269 0.315560428325906 no 1069 0.306861469310858 1449 16420915
SGTC_1345 1488-0192 31.4 µM 0.50338222110469 0.316030289695715 no 1070 0.307347784503388 1514 658348
SGTC_3216 9129716 49.47 µM 0.502600536671597 0.316295770614575 no 1071 0.307622575942036 1411 8056934
SGTC_2012 4023501 200 µM 0.50245151265478 0.316346393906228 no 1072 0.307674975740385 1426 3477460
SGTC_2390 9097792 176.6 µM 0.502025140568366 0.316491251035054 no 1073 0.307824918287291 1419 4497149
SGTC_2330 7979373 200 µM 0.499492875704749 0.317352151025921 no 1074 0.308716102236568 1388 1863007
SGTC_2513 baicalein 25.65 µM 0.49935907433247 0.317397667341313 no 1075 0.308763222574819 1408 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1813 st051246 8.6015 µM 0.497432435148359 0.318053373933915 no 1076 0.309442068776614 1527 5291959
SGTC_729 4092-0585 94.1 µM 0.496747281859448 0.318286694627479 no 1077 0.309683637712464 1447 2169061
SGTC_116 0155-0182 31.788 µM 0.49655530251696 0.318352083815384 no 1078 0.309751339865881 1470 771486
SGTC_1786 berberine 21.6 µM 0.495250940757245 0.318796506164329 no 1079 0.310211498178169 1442 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1365 1672-3266 55.4 µM 0.495052512131896 0.318864137660564 no 1080 0.310281526749097 1536 6415873
SGTC_273 hydroxyurea 18.1 mM 0.494612709220247 0.319014059553066 no 1081 0.310436764606241 1518 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_255 tunicamycin 200.472 nM 0.494241172760588 0.319140733562247 no 1082 0.310567932674348 1499 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_245 methotrexate 289.6 µM 0.492347970269667 0.31978654184662 no 1083 0.311236686955827 1513 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1201 1889-3372 45.9 µM 0.489603271985333 0.320723782461651 no 1084 0.312207330337374 1483 5392199
SGTC_282 k297-0036 65.7 µM 0.48926738806219 0.32083855646284 no 1085 0.312326203091211 1513 5061378
SGTC_880 0833-0487 87.2 µM 0.488678856003694 0.321039703473502 no 1086 0.312534537703269 1479 76075
SGTC_251 melphalan 456.522 µM 0.486328141800054 0.3218436481039 no 1087 0.313367264770385 1591 460612 A DNA alkylator.
SGTC_1074 carmofur 3.8 µM 0.486222463790957 0.321879809632922 no 1088 0.313404723000646 1513 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3317 9138495 8.753 µM 0.485525538918055 0.322118329759864 no 1089 0.313651800561112 1488 17020139
SGTC_2095 5432005 200 µM 0.484866802937742 0.322343847243528 no 1090 0.31388541606268 1504 783734
SGTC_208 k072-0098 12.366 µM 0.483073009440021 0.322958281661193 no 1091 0.314521948805016 1508 5948901
SGTC_3019 9081971 49.47 µM 0.481608851878701 0.323460163215982 no 1092 0.315041918392439 1615 16451803
SGTC_843 0310-0051 143 µM 0.480836836462166 0.323724922866307 no 1093 0.315316233714257 1529 2065037
SGTC_2378 9074213 121.43 µM 0.480633844057699 0.323794553134788 no 1094 0.315388378628474 1482 657714
SGTC_451 chloral hydrate 100 µM 0.477160500340928 0.324986930232925 no 1095 0.316623917941865 1544 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1338 1486-1223 76 µM 0.476912228445399 0.325072229291903 no 1096 0.316712311943885 1578 3444526
SGTC_3093 9117344 49.47 µM 0.476029387304722 0.325375622279459 no 1097 0.317026720886034 1509 24824913
SGTC_2341 7987486 176.74 µM 0.475982649398823 0.325391687234137 no 1098 0.317043369486002 1641 1258686
SGTC_438 sphingosine 6.67 µM 0.475633768046866 0.325511616486101 no 1099 0.317167656887253 1366 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2017 5132927 60.65 µM 0.472560957468549 0.326568685627247 no 1100 0.318263221269128 1477 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1437 4092-1038 11.6 µM 0.471271616305242 0.327012644037353 no 1101 0.318723391074193 1477 3977136
SGTC_1938 st074717 56.4 µM 0.471165656944843 0.32704913988804 no 1102 0.318761220739556 1448 17250979
SGTC_896 0964-0007 44.5 µM 0.471009663842238 0.327102871997093 no 1103 0.318816916914178 1525 6756758
SGTC_1149 3909-7961 23.3 µM 0.469847375236675 0.327503337200205 no 1104 0.319232032168617 1476 735261
SGTC_2870 9038528 12.99 µM 0.469542131929875 0.327608541369358 no 1105 0.319341088447478 1501 6463316
SGTC_3320 9137005 35.139 µM 0.466499139747813 0.328658076453476 no 1106 0.320429131599524 1520 4908713
SGTC_283 0987-0079 11.7 µM 0.465867782924264 0.328876002644127 no 1107 0.320655071522338 1577 411556
SGTC_1424 4048-1941 275 µM 0.465477031583179 0.329010907909391 no 1108 0.320794940689829 1641 X1424
SGTC_86 0417-1630 471.922 µM 0.465273975823428 0.329081020856975 no 1109 0.320867634403084 1545 3634867
SGTC_289 k017-0060 526 µM 0.464769408814024 0.329255268393638 no 1110 0.321048298506636 1519 5512909
SGTC_2745 rifampicin 24.3 µM 0.464026511846112 0.329511888478841 no 1111 0.321314375597137 1635 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_601 0986-0029 62.9 µM 0.463901051522986 0.329555234368193 no 1112 0.321359319712138 1537 24747981
SGTC_1764 st044502 93.5 µM 0.463788271160305 0.329594201351721 no 1113 0.321399723670751 1513 8407
SGTC_104 0074-0074 590.992 µM 0.46238899060656 0.330077823526709 no 1114 0.321901196464419 1501 3943124
SGTC_989 1501-0895 10.3 µM 0.461667372833078 0.330327341605563 no 1115 0.322159936032839 1594 2830112
SGTC_1007 4101-0031 70 µM 0.459834952110313 0.330961287544368 no 1116 0.322817346583886 1641 1146276
SGTC_3036 9090181 49.47 µM 0.457051034641733 0.33192534187724 no 1117 0.323817181917223 1550 25236586
SGTC_1226 3909-7979 35.4 µM 0.456321642453535 0.332178110527342 no 1118 0.32407935156682 1630 6615510
SGTC_2640 pentamidine 10.38 µM 0.455125466543944 0.332592806943069 no 1119 0.324509488860688 1626 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2598 perillyl alcohol 100 µM 0.451174398855384 0.333964037655004 no 1120 0.325931929793207 1600 10819 An apoptosis inducer.
SGTC_825 1988-2224 89.6 µM 0.448726004852641 0.334814875936926 no 1121 0.326814661450046 1552 1180859
SGTC_1245 0418-0076 17.2 µM 0.448222117243227 0.334990086726202 no 1122 0.326996451093358 1597 6790114
SGTC_1254 0550-0035 264 µM 0.448207708442866 0.334995097453779 no 1123 0.327001650020673 1636 15121435
SGTC_2625 euphol 100 µM 0.446899601619781 0.335450119976992 no 1124 0.327473775818276 1693 6708538 A triterpene alcohol.
SGTC_2805 7950783 58.44 µM 0.445817552524482 0.335826691259896 no 1125 0.327864520856457 1606 1178958 YDL195W SEC31
SGTC_1650 st011916 45.8 µM 0.442496532812771 0.336983490310839 no 1126 0.329064969355872 1645 242528
SGTC_122 0236-0016 402.397 µM 0.440588210012763 0.337648908696155 no 1127 0.329755569871682 1599 6808838
SGTC_3219 9131112 49.47 µM 0.439785240798782 0.337929050198433 no 1128 0.330046329132678 1550 17612988 YMR079W SEC14
SGTC_2158 5657123 3.6195 µM 0.439387873812221 0.338067717608051 no 1129 0.330190255746566 1572 2858827
SGTC_1665 st014639 11.4 µM 0.43798829617111 0.33855629694769 no 1130 0.330697383812941 1637 981133 YIL048W NEO1
SGTC_888 0916-0002 6.97 µM 0.437334061212035 0.338784777487016 no 1131 0.330934548397632 1641 2802138 YIL048W NEO1
SGTC_2358 9037157 4 µM 0.437179767229157 0.338838670711053 no 1132 0.330990490900223 1605 2388925
SGTC_2896 9052656 71.43 µM 0.436782050397808 0.338977604120787 no 1133 0.331134708832942 1543 6469436
SGTC_691 1548-0686 185 µM 0.436145637452989 0.339199966198932 no 1134 0.331365533578781 1525 46495133
SGTC_275 trichlorophene 5.69 µM 0.435738461983857 0.339342262310989 no 1135 0.331513248313615 1610 62616
SGTC_1181 1222-0449 220 µM 0.435056783279548 0.339580540688057 no 1136 0.331760605736036 1632 658318
SGTC_2785 7756463 72.73 µM 0.434878732124159 0.339642788406333 no 1137 0.331825226377654 1511 2201551
SGTC_2526 patulin 37.61 µM 0.434173619731645 0.339889342741577 no 1138 0.332081184069173 1631 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2346 9031566 143.75 µM 0.433545874415682 0.340108902032277 no 1139 0.332309123251635 1670 4771086
SGTC_1185 1319-0113 81.3 µM 0.432861353865629 0.340348380756301 no 1140 0.3325577486729 1620 4672763
SGTC_1186 1319-0216 26 µM 0.431334788496904 0.340882679722783 no 1141 0.333112479305988 1727 4565136
SGTC_2679 rapamycin 1 nM 0.430772449494256 0.341079579311976 no 1142 0.333316916890859 1586 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2789 5281112 71.43 µM 0.430708730310589 0.341101892928719 no 1143 0.333340085039048 1515 765948
SGTC_2725 haloperidol 53.21 µM 0.429352644858516 0.34157690780274 no 1144 0.33383330522179 1556 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1767 st044992 70.3 µM 0.429209498999214 0.341627064149614 no 1145 0.333885385401694 1523 9600693
SGTC_656 4090-1979 187 µM 0.427850504920031 0.342103376234502 no 1146 0.334379982001328 1702 22330961
SGTC_272 doxorubicin 8.13 µM 0.426064198019968 0.342729838902699 no 1147 0.335030533622732 1581 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2528 xanthyletin 44.79 µM 0.425944865018346 0.342771704748538 no 1148 0.335074010944084 1599 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3172 9105863 49.47 µM 0.425118933509479 0.343061520932006 no 1149 0.335374988168625 1628 2348785
SGTC_370 0180-0345 38.7 µM 0.423569911171546 0.343605315807727 no 1150 0.335939751381824 1560 3989527
SGTC_3325 9138760 55.175 µM 0.423467942767526 0.34364112388435 no 1151 0.33597694139739 1541 43844959
SGTC_629 3448-6466 76.7 µM 0.422174892088095 0.344095323971698 no 1152 0.336448683294233 1592 573744
SGTC_314 1671-0008 2.74 µM 0.42217163242272 0.344096469254194 no 1153 0.336449872839231 1568 3913060
SGTC_426 0988-0037 14.6 µM 0.422127721871466 0.344111897353192 no 1154 0.336465897213109 1651 5383008
SGTC_108 0509-0257 621.132 µM 0.420037537326333 0.344846589478616 no 1155 0.337229015972194 1590 536624
SGTC_2636 apigenin dimethyl ether 100 µM 0.418600623578461 0.345351999097841 no 1156 0.337754016890737 1619 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1385 3091-4834 14.1 µM 0.417104185168473 0.3458786387695 no 1157 0.338301101924036 1660 4072814
SGTC_2275 7947463 200 µM 0.416229664578297 0.346186545869145 no 1158 0.338620977346944 1601 1225414
SGTC_1063 disulfiram 1.84 µM 0.415496583578917 0.346444732337024 no 1159 0.338889207818382 1599 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2798 7813637 45.45 µM 0.4130910922642 0.347292431791355 no 1160 0.339769937744844 1659 956368
SGTC_2246 7293507 91.5585 µM 0.411214852316978 0.347954153078923 no 1161 0.340457499281758 1755 887656
SGTC_3181 9108277 49.47 µM 0.409878876357576 0.348425614019752 no 1162 0.340947400806272 1566 17097298
SGTC_2802 7925815 54.55 µM 0.409345655751753 0.348613851037345 no 1163 0.341143007423184 1584 1262923
SGTC_990 3985-0011 41.3 µM 0.408894935570457 0.348772992911702 no 1164 0.341308382892108 1606 5399565 YGL099W LSG1
SGTC_380 3970-0968 6 µM 0.408575862836647 0.348885668329137 no 1165 0.341425473520016 1581 2891601
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.407295725843484 0.349337862081351 no 1166 0.341895400810115 1601 5282362
SGTC_2595 hexamethylquercetagetin 100 µM 0.40678013426893 0.349520049380221 no 1167 0.342084739315941 1620 386331
SGTC_2912 7964298 10.93 µM 0.405622367191773 0.349929279425166 no 1168 0.342510045859403 1602 2975850
SGTC_816 0325-0417 81.3 µM 0.403437549896444 0.350702010403904 no 1169 0.343313183850072 1597 68101
SGTC_628 1636-0253 16 µM 0.401990089124634 0.351214292113817 no 1170 0.343845660098062 1704 4456143
SGTC_1368 1852-0141 284 µM 0.401584239541872 0.351357977975751 no 1171 0.343995015334187 1626 2838987
SGTC_1602 st001878 87.6 µM 0.401325695944678 0.351449523114386 no 1172 0.344090173722924 1675 595405 YLR310C CDC25
SGTC_1202 1988-0068 29.6 µM 0.401147749095596 0.351512535556643 no 1173 0.344155673773643 1557 2850480
SGTC_2942 9052777 62.25 µM 0.400806029477316 0.351633552723929 no 1174 0.344281469679776 1675 6469503
SGTC_2263 7948595 193.29 µM 0.399561907625284 0.352074275107803 no 1175 0.344739608861687 1617 2971371
SGTC_3082 9117008 49.47 µM 0.39852600118828 0.352441390177018 no 1176 0.345121247999759 1620 41448529
SGTC_2070 5230947 200 µM 0.397223336644899 0.352903236851312 no 1177 0.345601387350465 1696 2835538
SGTC_3007 9078383 71.4286 µM 0.397065388987703 0.352959250364287 no 1178 0.345659620998816 1621 6496995
SGTC_2730 imipramine 71.33 µM 0.393484468841587 0.354230017227364 no 1179 0.346980846442964 1686 3696 A tricyclic antidepressant.
SGTC_277 nystatin 15.5 µM 0.392271789582424 0.354660731688981 no 1180 0.347428702669172 1595 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1117 retinoic acid 1.10837 µM 0.392187719426435 0.354690598279404 no 1181 0.347459758637823 1753 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2504 purpurogallin 52.29 µM 0.391492645113495 0.354937563155282 no 1182 0.347716562047806 1613 5281571 An antioxidant.
SGTC_2718 lomofungin 53.02 µM 0.391237151313167 0.355028357258954 no 1183 0.347810974820428 1749 5351222 A RNA synthesis inhibitor.
SGTC_279 1273-0055 2.93 µM 0.389766398862259 0.355551174324098 no 1184 0.348354646205306 1740 2847562
SGTC_2290 7904846 200 µM 0.389459734112816 0.355660220544605 no 1185 0.348468045755213 1623 2962154
SGTC_3220 9131269 49.47 µM 0.388226940561133 0.356098705923026 no 1186 0.348924048986624 1642 17722206
SGTC_2418 pentamidine 31.67 µM 0.387903547896109 0.356213763179402 no 1187 0.349043706237385 1567 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2385 9074692 200 µM 0.387412888924852 0.356388355758056 no 1188 0.349225281699775 1610 17046906
SGTC_1660 st012960 28.1 µM 0.386100570449094 0.356855469626278 no 1189 0.349711093692352 1647 24207266
SGTC_313 3474-0040 5.03 µM 0.38575011916747 0.35698024753983 no 1190 0.34984087022304 1614 1043375 YIL048W NEO1
SGTC_1769 st044406 64.4 µM 0.384479785176053 0.357432677162484 no 1191 0.350311437894066 1642 670903
SGTC_1461 k072-0203 53.8 µM 0.382590617961525 0.358105874891932 no 1192 0.351011663864782 1603 5418714
SGTC_2956 9076196 2.52 µM 0.382491444531723 0.358141227188086 no 1193 0.351048436824316 1661 16423868
SGTC_835 0312-0010 67.2 µM 0.382453995840958 0.358154576817972 no 1194 0.35106232295467 1634 1626196
SGTC_1590 st077108 57.8 µM 0.379898486800638 0.359065968171785 no 1195 0.352010385320227 1782 5489485
SGTC_110 0850-0284 111.64 µM 0.379234868451026 0.359302771121687 no 1196 0.352256730378561 1606 3906265
SGTC_2905 7799065 20.05 µM 0.377591174127023 0.359889533094923 no 1197 0.352867161086761 1754 1296806
SGTC_334 1502-1024 68.5 µM 0.377003864023319 0.360099269794664 no 1198 0.353085366681077 1679 3296216
SGTC_1341 1486-1360 280 µM 0.376924137618181 0.360127744463794 no 1199 0.353114991467058 1630 3976547
SGTC_3148 9097893 49.47 µM 0.376399604490724 0.360315103335795 no 1200 0.353309919993502 1508 17174100
SGTC_666 0272-0154 136 µM 0.376348147402792 0.360333485187568 no 1201 0.35332904470005 1684 6870312
SGTC_1093 fluphenazine 7.97 µM 0.374964172581781 0.360827999095609 no 1202 0.353843556024735 1692 6602611 An atypical antipsychotic.
SGTC_3113 9123498 49.47 µM 0.374471792706466 0.361003989616598 no 1203 0.35402666934502 1691 8897275
SGTC_3326 9140064 16.379 µM 0.374346621474356 0.361048734055451 no 1204 0.354073225210323 1604 1868434
SGTC_3254 9136651 49.47 µM 0.372573076378473 0.361682919906267 no 1205 0.354733107141026 1644 16454030
SGTC_1370 2001-0092 44.6 µM 0.371873575273402 0.361933152762391 no 1206 0.354993490166275 1816 790957
SGTC_1259 0671-0132 43 µM 0.370188472291328 0.362536207663942 no 1207 0.355621032612648 1664 X1259
SGTC_1298 1079-1278 263 µM 0.369878746041363 0.362647087866913 no 1208 0.355736419171181 1680 2840950
SGTC_556 4058-0063 51.5 µM 0.369808289560465 0.362672312487492 no 1209 0.355762669134188 1680 6615692
SGTC_196 k015-0023 18.111 µM 0.368177468786699 0.363256340463347 no 1210 0.356370454746151 1666 5211998
SGTC_2434 5670830 169.91 µM 0.367894839608937 0.363357587728337 no 1211 0.356475824103965 1674 1549830
SGTC_75 0159-0059 199.013 µM 0.365120108258274 0.364352095647347 no 1212 0.357510875679391 1786 5377270
SGTC_2469 5655019 90.81 µM 0.365095368238985 0.364360966984767 no 1213 0.357520109120373 1790 2788239
SGTC_586 0957-0265 8.15 µM 0.362812872434615 0.365179742006615 no 1214 0.358372337678797 1745 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1734 st037168 69.4 µM 0.362642628556668 0.365240836441435 no 1215 0.35843593095473 1660 708907
SGTC_106 0092-0003 11.579 µM 0.36214119374365 0.3654208033171 no 1216 0.358623260834189 1808 1072148
SGTC_513 4245-1575 41.7 µM 0.360179727797334 0.366125065315924 no 1217 0.359356366826877 1777 719745
SGTC_236 1509-0011 5.31 µM 0.359297500714499 0.366441975161102 no 1218 0.359686271911148 1733 3107280
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.358553654166313 0.366709247334142 no 1219 0.359964511458217 1695 5379071
SGTC_2697 mebhydrolin 72.4 µM 0.358498393041581 0.366729105839626 no 1220 0.359985185123559 1827 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_465 cgp-37157 41 µM 0.358248953384613 0.366818748315962 no 1221 0.360078507755468 1772 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1811 st050069 61.5 µM 0.357239017865814 0.367181768489331 no 1222 0.360456439199862 1772 3877702
SGTC_2463 5473429 200 µM 0.356924931297625 0.367294690775585 no 1223 0.360574002432354 1671 5399405
SGTC_1647 st011722 22.4 µM 0.356507970741039 0.367444616667111 no 1224 0.360730091965972 1707 2854783
SGTC_3112 9123419 49.47 µM 0.355943590522934 0.367647582212938 no 1225 0.360941405129767 1723 17015854
SGTC_2733 amorolfine 100 µM 0.355399907704719 0.367843139408183 no 1226 0.361145008997565 1787 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1870 st057514 26.5 µM 0.354927734509694 0.36801300311839 no 1227 0.361321865139673 1677 5393161
SGTC_1838 st055369 84.5 µM 0.354689047720239 0.368098880213202 no 1228 0.361411278414183 1656 676036
SGTC_2165 5727197 32.143 µM 0.353455573559202 0.368542776718291 no 1229 0.361873464595071 1743 1361712
SGTC_55 0767-0285 6.563 µM 0.351747015871773 0.369157933693909 no 1230 0.362513998695157 1837 3116166
SGTC_855 0428-0020 25 µM 0.350909359335452 0.369459649979219 no 1231 0.362828174855482 1705 6812414
SGTC_1909 st060837 51.5 µM 0.349133987942369 0.370099388271478 no 1232 0.363494360702446 1671 678937
SGTC_2931 9014674 55.67 µM 0.34873989676609 0.370241444128001 no 1233 0.363642294559289 1640 2996810
SGTC_3004 9076122 71.4286 µM 0.347605273294059 0.370650534327068 no 1234 0.36406832273206 1791 44782551
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.347394230828571 0.370726642154657 no 1235 0.364147583462049 1648 688669
SGTC_1425 4048-4433 7.33 µM 0.346889249661681 0.370908773044277 no 1236 0.364337261651956 1798 23734946
SGTC_3268 9137683 49.47 µM 0.345776239987904 0.371310302852976 no 1237 0.364755441366473 1717 1953228
SGTC_1728 st035614 33.7865 µM 0.342754934310569 0.372400975508348 no 1238 0.365891415801561 1732 15945546
SGTC_1784 st039334 36.3 µM 0.341825294430786 0.372736776212811 no 1239 0.366241186383337 1815 3496984
SGTC_3227 9130768 49.47 µM 0.341063213843961 0.373012124007338 no 1240 0.366527996867341 1761 17720899
SGTC_939 1165-0479 45.3 µM 0.340456271810471 0.373231465018756 no 1241 0.366756474002834 1815 1377347
SGTC_2988 9073640 71.4286 µM 0.340118104317409 0.373353692211403 no 1242 0.366883794192456 1745 9102229
SGTC_462 ag-879 158 µM 0.33967106547352 0.373515289400639 no 1243 0.367052126960918 1807 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_862 0452-0056 10.2 µM 0.338756773077895 0.373845860304899 no 1244 0.367396483930786 1751 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2893 9048488 25.97 µM 0.338041644315808 0.374104486453067 no 1245 0.367665902731533 1636 6467338
SGTC_3352 9151559 45.5865 µM 0.336504465435909 0.374660598544291 no 1246 0.368245242394045 1681 17159339
SGTC_1600 coumarin 106 71.1 µM 0.335981252898415 0.374849943034058 no 1247 0.368442501789234 1768 100336 A hepatotoxic, DNA x-linker.
SGTC_218 alverine citrate 93.75 µM 0.334490774167358 0.37538949508856 no 1248 0.369004625772073 1794 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1229 0139-0193 12.2 µM 0.334211709478379 0.375490543406657 no 1249 0.3691099043229 1842 3090752
SGTC_511 blebbistatin 171 µM 0.333299288173411 0.37582098746401 no 1250 0.369454188327003 1820 3476986 A myosin inhibitor.
SGTC_1340 1486-1359 257 µM 0.332134923567253 0.376242808005336 no 1251 0.369893690163211 1753 4309068
SGTC_2678 equilin 100 µM 0.331557980923397 0.376451874896634 no 1252 0.370111526335721 1837 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2858 9025781 8.96 µM 0.330769070089101 0.376737811431924 no 1253 0.370409462755359 1825 4894980 YPL153C RAD53
SGTC_1284 0929-0043 16 µM 0.329549399439732 0.377180007627723 no 1254 0.370870230907708 1717 1239883
SGTC_2115 tiliquinol 12.7705 µM 0.329265293463966 0.377283034476899 no 1255 0.370977587312635 1762 71208 A bioactive hydroxyquinoline.
SGTC_1124 fisetin 1.16336 µM 0.328958239030125 0.377394393068385 no 1256 0.371093626647437 1698 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2541 muurolladie-3-one 83.07 µM 0.328114037747078 0.377700609757343 no 1257 0.371412720221815 1769 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_867 0518-0118 155 µM 0.327962612165171 0.37775554441651 no 1258 0.3714699658451 1785 6848158
SGTC_1187 1391-0724 117 µM 0.327000442169772 0.378104661265456 no 1259 0.371833775390029 1757 6997986
SGTC_382 3229-0966 23.2 µM 0.32659351730657 0.37825234116186 no 1260 0.371987673673116 1824 5722370
SGTC_2054 5233173 129 µM 0.325971615622451 0.378478074132073 no 1261 0.372222915329763 1771 6889
SGTC_538 2922-0838 53.3 µM 0.325867358247448 0.378515920713381 no 1262 0.372262356583276 1871 777039
SGTC_1910 st062352 60.4 µM 0.325147606394509 0.378777230376943 no 1263 0.372534679999688 1656 2245730
SGTC_148 3253-0744 288.01 µM 0.324737386377521 0.378926187697652 no 1264 0.372689918289513 1689 6893655
SGTC_2102 5377816 72.7585 µM 0.323238700830452 0.379470536631842 no 1265 0.373257236836816 1859 1379702
SGTC_2878 9043973 25.97 µM 0.322969610680842 0.379568300244735 no 1266 0.373359128463859 1834 6465167
SGTC_5 0352-0601 109.883 µM 0.322861187281796 0.379607693916091 no 1267 0.373400185745834 1750 762456
SGTC_2162 5663267 200 µM 0.321664997768877 0.380042390497649 no 1268 0.373853248678726 1839 6456493
SGTC_977 1348-1378 135 µM 0.320184707986474 0.380580539251625 no 1269 0.374414157380763 1738 X977
SGTC_3218 9131285 49.47 µM 0.31862778624997 0.381146796429771 no 1270 0.375004390222317 1873 17156417
SGTC_543 3844-1095 191 µM 0.317494580047409 0.381559107138245 no 1271 0.375434175702979 1833 4230703
SGTC_2164 5685496 200 µM 0.314072481120076 0.382805032815269 no 1272 0.376732994836302 1837 759046
SGTC_2860 9025725 38.96 µM 0.31396113426794 0.382845592691518 no 1273 0.376775278817189 1687 40546248
SGTC_2255 7941087 197.44 µM 0.312910250191123 0.383228457291147 no 1274 0.377174424921279 1878 935561
SGTC_2147 5545932 89.7195 µM 0.311916666496119 0.383590550793054 no 1275 0.37755192797056 1773 797404
SGTC_1885 st057546 99.9 µM 0.309093816833741 0.384619840857105 no 1276 0.378625081252992 1858 702008
SGTC_1148 3909-7663 27.7 µM 0.308460198721082 0.384850987871604 no 1277 0.378866090730478 1865 4084526
SGTC_1629 st005085 44.9 µM 0.30822943768929 0.384935180807387 no 1278 0.378953877068224 1687 24207091
SGTC_1747 st037496 66.6 µM 0.308108654110825 0.384979250740695 no 1279 0.37899982816522 1750 723305
SGTC_945 3381-0768 11.3 µM 0.307608757965077 0.385161662106955 no 1280 0.379190027629648 1868 1126236 YIL048W NEO1
SGTC_2223 6903751 107.57 µM 0.306541398317332 0.385551225081967 no 1281 0.379596232293576 1832 5598863
SGTC_1312 1218-2183 165 µM 0.306365725056993 0.385615353065963 no 1282 0.379663100951585 1830 6744073
SGTC_857 0438-0306 1.35 µM 0.306360086749607 0.385617411332455 no 1283 0.379665247188986 1790 4686136
SGTC_954 1189-0853 2.85 µM 0.304306758572123 0.386367193385223 no 1284 0.380447098290305 1804 2828194
SGTC_2432 5630864 12.22 µM 0.304198734825759 0.386406650521647 no 1285 0.380488244329766 1742 5714970
SGTC_215 1287-0124 461.5 µM 0.30331781048147 0.386728463882152 no 1286 0.380823837170214 1903 5560863
SGTC_2490 carminic acid 95.39 µM 0.301687681264644 0.387324177042125 no 1287 0.381445079962481 1790 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2148 5546263 113.568 µM 0.300000526669113 0.387941009034686 no 1288 0.382088376945881 1792 792097
SGTC_397 arbidol 50 µM 0.29809095118661 0.388639500386575 no 1289 0.382816873858281 1884 131410 A RNA synthesis inhibitor.
SGTC_2670 beta-carotene 100 µM 0.297012312422673 0.389034208081984 no 1290 0.383228554561703 1842 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.295642521465231 0.389535622540995 no 1291 0.38375154848645 1820 6708739 YPR165W RHO1
SGTC_2208 7283366 200 µM 0.295630010669084 0.389540202989503 no 1292 0.383756326156685 1886 898663
SGTC_1372 2752-0194 270 µM 0.294625809001376 0.389907910963455 no 1293 0.384139872068364 1758 823334
SGTC_1762 st045503 25.4615 µM 0.29445386473929 0.389970881589985 no 1294 0.384205556042743 1760 4645554
SGTC_654 1124-0271 80.9 µM 0.292927937919314 0.390529843497962 no 1295 0.384788616837814 1726 5403748
SGTC_3184 9108758 49.47 µM 0.291675361969745 0.390988843508864 no 1296 0.385267424391203 1806 902885
SGTC_3041 9091929 49.47 µM 0.291598807224022 0.391016901533325 no 1297 0.385296693758585 1847 25236887
SGTC_934 2950-0684 338 µM 0.291562616444237 0.391030165987323 no 1298 0.385310530897393 1902 1121253
SGTC_11 0438-0307 1.3 µM 0.291140122347542 0.391185025672544 no 1299 0.385472077574646 1917 4011476
SGTC_542 3381-0244 89.3 µM 0.288880636187466 0.392013503053868 no 1300 0.386336361183166 1908 1112843
SGTC_1060 3448-7350 82 µM 0.288368972963107 0.392201180859181 no 1301 0.386532157704121 1912 570178
SGTC_1896 st058441 89 µM 0.288219516788967 0.392256006040973 no 1302 0.386589355071954 1760 688759
SGTC_2495 cafestol 54.53 µM 0.288007244231993 0.392333877905255 no 1303 0.386670596710044 1851 16667697 An anti-infammatory.
SGTC_2201 6605497 169.863 µM 0.287930414375884 0.392362063883798 no 1304 0.386700002504912 1896 670741
SGTC_608 k048-0125 159 µM 0.287883210937577 0.392379381326297 no 1305 0.386718069432029 1907 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1954 st077032 68.9 µM 0.287802196052083 0.392409103611789 no 1306 0.386749078127521 1698 698907
SGTC_3169 9102970 49.47 µM 0.287677861716994 0.392454719913936 no 1307 0.386796668881206 1840 17027839
SGTC_1085 doxorubicin 7.67 µM 0.286928220545148 0.392729782700566 no 1308 0.387083640861425 1892 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2176 5809774 33.9695 µM 0.285693132621273 0.393183085296715 no 1309 0.387556582477029 1935 2870539
SGTC_2827 7993847 71.43 µM 0.285234299219983 0.393351523501765 no 1310 0.387732322168805 1813 2985692
SGTC_508 roscovitine 141 µM 0.284534082076109 0.393608612392502 no 1311 0.388000559576895 1847 160355 A CDKinase inhibitor.
SGTC_1917 st066507 28.5 µM 0.283985469938756 0.393810071018019 no 1312 0.388210757872009 1759 3156428
SGTC_911 3456-4043 236 µM 0.283507317697597 0.393985678894546 no 1313 0.388393986485636 1868 914281
SGTC_2314 7727897 200 µM 0.283421856775511 0.394017067845686 no 1314 0.388426737849314 1744 900724
SGTC_2985 9022375 71.43 µM 0.28288955062715 0.394212594118811 no 1315 0.388630752471842 1819 4939335
SGTC_2540 epiandrosterone 100 µM 0.282655020916914 0.394298749850802 no 1316 0.388720649389797 1833 441302 A steroid.
SGTC_994 3910-0338 138 µM 0.279757793871584 0.395363486878399 no 1317 0.389831667388757 1891 3479481
SGTC_1429 4049-0205 9.46 µM 0.278161110933035 0.395950605800488 no 1318 0.390444343098077 1847 22774478
SGTC_2130 NSC 7 2.4545 µM 0.27714110697992 0.396325796832817 no 1319 0.390835879362082 1923 21448
SGTC_944 3370-0224 231 µM 0.276713641207821 0.39648306139294 no 1320 0.390999998283298 1757 4580514
SGTC_2207 7258803 200 µM 0.276350555307554 0.396616653842886 no 1321 0.391139414790467 1891 3666799
SGTC_1877 wortmannin 25 µM 0.275433597001216 0.39695409000196 no 1322 0.391491567607029 1925 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2177 5811945 192 µM 0.275290514517647 0.39700675062022 no 1323 0.391546525681229 1892 5343475
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.274031963731695 0.397470033216205 no 1324 0.392030028998465 1796 688803
SGTC_1403 3909-7815 62.9 µM 0.273082798670649 0.397819524188615 no 1325 0.392394784520567 1825 6615483
SGTC_747 3448-8087 38.7 µM 0.272551976012321 0.398015013566026 no 1326 0.392598816099628 1792 5168703
SGTC_1246 0422-0085 105 µM 0.270938904033291 0.398609226602617 no 1327 0.393219011304932 1958 264295
SGTC_2939 9044578 71.43 µM 0.270594031657326 0.398736299016225 no 1328 0.393351643340751 1783 2653634
SGTC_262 fenpropimorph 62.5 µM 0.270474143936954 0.398780475617502 no 1329 0.393397753014058 1805 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1055 3448-0672 86 µM 0.270469006912751 0.398782368553186 no 1330 0.393399728783658 1838 748378
SGTC_1853 st056710 91.2 µM 0.270449284578695 0.398789636033744 no 1331 0.393407314287935 1988 269167
SGTC_783 0848-0141 92.7 µM 0.269778135929016 0.399036968420523 no 1332 0.393665472181461 1803 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_430 0958-0115 16.4 µM 0.269718432218907 0.399058972457902 no 1333 0.393688439529634 1810 6833180
SGTC_299 1273-0059 1.44 µM 0.268549834430683 0.399489728272524 no 1334 0.394138060374483 1923 2848077
SGTC_120 rhodamine 6G 52.259 µM 0.267702929149352 0.399801981808355 no 1335 0.394463997475386 1828 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_566 0958-0068 16.5 µM 0.26764205701674 0.399824427802963 no 1336 0.394487427367836 1884 6815365
SGTC_2377 9073351 62.6 µM 0.265225218532086 0.40071587973961 no 1337 0.395417984387546 1791 7337946 YHR072W ERG7
SGTC_2051 5263410 176 µM 0.265003159111062 0.400797812473906 no 1338 0.39550351408948 1942 227584
SGTC_848 0368-0089 85.6 µM 0.264789739534091 0.40087656149839 no 1339 0.395585720762055 1930 762535
SGTC_2772 vinpocetine 57.06 µM 0.262992077535931 0.401540034755455 no 1340 0.396278342727128 1909 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1891 st059073 26.2 µM 0.26203418308614 0.401893686349551 no 1341 0.396647544185843 1987 688754
SGTC_2531 methyl deoxycholate 70.07 µM 0.260963526447718 0.402289064466846 no 1342 0.397060317273237 1813 16667744 Haematoxylin.
SGTC_823 0417-1665 178 µM 0.260449924415738 0.402478765832058 no 1343 0.397258368588859 1870 3429856
SGTC_2324 6149169 200 µM 0.258703574638161 0.403123960025674 no 1344 0.397931980638354 1932 2888231
SGTC_2737 bleomycin 30.5 nM 0.258201284863063 0.403309581430554 no 1345 0.398125783181548 1872 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2219 9098279 200 µM 0.257170271461916 0.403690661095707 no 1346 0.398523666155777 1948 902349
SGTC_703 3875-0075 71.8 µM 0.257155186904509 0.403696237278106 no 1347 0.398529488288631 1865 2850814
SGTC_2220 6782180 200 µM 0.255597821381558 0.40427204072174 no 1348 0.399130700411285 1947 833803
SGTC_1457 k015-0032 57.3 µM 0.254976858153124 0.404501686847781 no 1349 0.399370486566344 1830 4302660
SGTC_1364 1653-0028 37.6 µM 0.253695078681874 0.40497582161371 no 1350 0.399865568174396 1855 5718652
SGTC_41 0478-0632 82.643 µM 0.252750412935921 0.40532534616785 no 1351 0.400230544215069 2024 3750424
SGTC_2018 5133068 143 µM 0.252202697895328 0.405528034309862 no 1352 0.400442196423731 1849 785362
SGTC_1360 1598-0022 39.8 µM 0.25198701083037 0.405607858702078 no 1353 0.400525551885989 1929 761525
SGTC_233 rapamycin 362 pM 0.251408341016983 0.405822040055051 no 1354 0.400749209782815 1964 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2059 5238311 157 µM 0.248922075546419 0.406742594210966 no 1355 0.401710529419644 1837 703021
SGTC_1968 st069590 43.6 µM 0.248488239929317 0.406903277325921 no 1356 0.401878333990171 1952 6384066
SGTC_2565 isoliquiritigenin 100 µM 0.248482123848481 0.406905542699051 no 1357 0.401880699776682 1723 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2796 7949634 45.45 µM 0.248273187831794 0.406982933676916 no 1358 0.401961521339781 1831 2971588
SGTC_160 3453-0671 289.699 µM 0.247798967998764 0.407158600620922 no 1359 0.40214497672525 1852 5322268
SGTC_1808 st050063 61.5 µM 0.245835920482347 0.407885977611855 no 1360 0.40290462481833 1967 4011993
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.245618522568222 0.40796655063669 no 1361 0.402988774733389 1881 3256 An antibiotic and ribosome inhibitor.
SGTC_2517 totarol 10 µM 0.244961418110782 0.408210113391958 no 1362 0.403243152609445 1803 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2741 miltefosine 3.04 µM 0.244657445510424 0.408322796073397 no 1363 0.403360840155903 1894 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1119 parthenolide 318.541 nM 0.243382507529954 0.408795498221697 no 1364 0.403854546720678 1935 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2914 7968218 45.32 µM 0.242455697802987 0.409139209996778 no 1365 0.404213540433612 1966 2977111
SGTC_518 1021-0119 62.6 µM 0.240918272837396 0.409709525288598 no 1366 0.404809229762107 1798 1097762
SGTC_3053 9095903 49.47 µM 0.240481816315148 0.409871465842743 no 1367 0.404978379097906 1983 17174018
SGTC_950 1165-0508 94.1 µM 0.239272441844535 0.410320266088369 no 1368 0.40544716653004 1831 6148369
SGTC_2375 9072683 200 µM 0.239272240325819 0.410320340881999 no 1369 0.405447244655664 2029 16798029
SGTC_2237 6667747 47.222 µM 0.239160399511092 0.410361851080935 no 1370 0.405490604154795 1832 729940 YDL015C TSC13
SGTC_2282 7944268 200 µM 0.238911003450492 0.410454419116346 no 1371 0.405587296541538 1939 2970414
SGTC_958 1222-0007 33 µM 0.238288659370014 0.41068543556543 no 1372 0.405828608284207 1933 7312461
SGTC_3296 9122258 64.045 µM 0.237658726390297 0.410919300599045 no 1373 0.406072899041538 1889 4730474
SGTC_269 exalamide 29 µM 0.236353852395587 0.411403840722331 no 1374 0.406579051117011 1901 3316 A derivative of salicylamide.
SGTC_2502 avocadyne acetate 18.59 µM 0.235154032893912 0.411849490160938 no 1375 0.40704459104088 1938 3952079
SGTC_1460 k062-0059 9.15 µM 0.23381187406614 0.412348143490892 no 1376 0.407565515443247 1824 1373085
SGTC_1952 st077036 64.1 µM 0.23267823587849 0.412769435271491 no 1377 0.408005635331541 2026 2937007
SGTC_2061 5245884 80.95 µM 0.232658226378178 0.412776872267629 no 1378 0.408013404797185 1869 573863
SGTC_312 4092-0653 6.84 µM 0.231821853791437 0.413087757563531 no 1379 0.408338191254783 1979 1148278
SGTC_2464 5717415 7.67 µM 0.23174830750495 0.413115097821367 no 1380 0.408366754314392 1817 5285744
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.231024285270664 0.413384269907462 no 1381 0.408647967694027 1867 75037 A free radical scavenger.
SGTC_2395 5646831 180.19 µM 0.230951920501585 0.413411175431647 no 1382 0.408676077072686 1934 6808628
SGTC_287 k060-0039 29.6 µM 0.230458305318535 0.413594714463829 no 1383 0.408867829531765 2010 5861974
SGTC_1080 nisoldipine 24.4 µM 0.229668087997459 0.413888577216188 no 1384 0.409174847078833 1876 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2662 daunorubicin 22.37 µM 0.228969586379329 0.414148373273025 no 1385 0.40944627737714 1930 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1812 st052057 4.327 µM 0.228886056135319 0.414179443475044 no 1386 0.40947873925016 1876 3645418
SGTC_2186 6124449 200 µM 0.228530305448312 0.414311775758858 no 1387 0.409616999518858 1972 3834182 YLR033W RSC58
SGTC_532 1548-0774 215 µM 0.228085891665238 0.41447710264193 no 1388 0.409789733933143 2010 5932993
SGTC_820 1582-0060 59.9 µM 0.22795835590181 0.414524550167541 no 1389 0.409839307672468 1877 3848840
SGTC_1772 st048439 82.2 µM 0.227878110657969 0.414554404693787 no 1390 0.409870500107531 1876 2927068 YDL195W SEC31
SGTC_1712 st032288 53.4 µM 0.227494567034707 0.414697105487988 no 1391 0.410019596688627 1924 2883011
SGTC_785 1270-0111 65.3 µM 0.22447067067847 0.415822565656122 no 1392 0.411195543026342 1980 6741994
SGTC_2685 mycophenolic acid 18.85 µM 0.223882401943153 0.416041593204466 no 1393 0.41142440469859 1974 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1290 0986-0249 10.2 µM 0.223707615478492 0.416106675719745 no 1394 0.411492409913328 2020 53329
SGTC_627 1391-0720 175 µM 0.223332307232982 0.416246431180699 no 1395 0.411638442318602 1934 997839
SGTC_1127 asiatic acid 681.4 nM 0.220416893941707 0.417332417945871 no 1396 0.412773244732969 1813 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3059 1327-0034 3 µM 0.220069897590086 0.417461715706314 no 1397 0.412908359176768 1870 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3294 9122953 26.2835 µM 0.219099011970704 0.417823534427972 no 1398 0.413286460203975 1935 16459826
SGTC_391 gliotoxin 8.33 µM 0.218500916199678 0.4180464606763 no 1399 0.41351942227006 1958 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2779 methotrexate 400 µM 0.216372938478301 0.418839827776967 no 1400 0.414348529304471 2026 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3084 9116877 49.47 µM 0.215263756785273 0.419253491541758 no 1401 0.414780842557091 2041 27241325
SGTC_900 1112-0045 141 µM 0.215192502065588 0.419280068689443 no 1402 0.414808618240792 2027 56211 YIL048W NEO1
SGTC_45 0kpi-0036 14.9 µM 0.214597197363061 0.419502124515955 no 1403 0.415040689606238 1939 2795021
SGTC_2371 9071574 200 µM 0.214254427012503 0.419629993621868 no 1404 0.415174327377302 2021 45596039
SGTC_928 2764-0428 58.7 µM 0.214253353230051 0.419630394205451 no 1405 0.41517474603423 1947 662578
SGTC_2661 dactinomycin 12.96 µM 0.213759451724914 0.419814657142334 no 1406 0.415367323444071 1960 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1037 k284-1091 78.7 µM 0.211859429527801 0.420523673918208 no 1407 0.41610835131854 1879 3334711
SGTC_2687 chenodiol 100 µM 0.21123459603104 0.420756894733952 no 1408 0.416352108017158 1944 5702181 A cholesterol synthesis inhibitor.
SGTC_2987 9018338 71.43 µM 0.210200323417596 0.421143000913248 no 1409 0.416755663575775 2006 5055682
SGTC_3177 9107506 49.47 µM 0.210103978561055 0.421178971453448 no 1410 0.416793260171742 2039 8897194
SGTC_138 0850-0259 40.9225 µM 0.20905452792014 0.421570828449521 no 1411 0.417202835893261 2035 6813004
SGTC_3121 9125696 49.47 µM 0.207048349660857 0.422320136235249 no 1412 0.41798604947577 2081 1235365
SGTC_2325 6158266 200 µM 0.206687643251602 0.422454890022194 no 1413 0.418126904143615 1927 3623240
SGTC_815 1582-0027 36.9 µM 0.204586260199691 0.423240111004611 no 1414 0.418947695559151 1984 3128206
SGTC_810 3825-7150 143 µM 0.203766580600647 0.423546482437954 no 1415 0.419267954854509 2087 22330411 YGL099W LSG1
SGTC_3044 9093193 49.47 µM 0.202566605973338 0.423995079969737 no 1416 0.419736896702188 1880 25236277
SGTC_1638 st008370 60.6 µM 0.199849485180838 0.42501120934795 no 1417 0.420799149166948 2011 24207134
SGTC_580 1123-0028 41 µM 0.199501865353215 0.425141245825566 no 1418 0.420935092170664 2036 1677248 YPR107C YTH1
SGTC_631 k072-0230 41.5 µM 0.198898909047638 0.425366817038242 no 1419 0.421170911459748 2000 5773147
SGTC_2274 7947094 46.08 µM 0.198256799494178 0.425607062684857 no 1420 0.421422074879339 2103 2971028
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.198115400100435 0.425659971060769 no 1421 0.421477388051062 1891 2374 Ca(2+)-ATPase inhibitor.
SGTC_1382 3002-2117 298 µM 0.197391027859779 0.425931035337027 no 1422 0.421760775115995 2066 1497314
SGTC_1884 5633444 25 µM 0.197367977950599 0.425939661321467 no 1423 0.421769793308821 1982 5724239
SGTC_66 0109-0187 42.4 µM 0.196397487900608 0.426302880632901 no 1424 0.422149531169331 1851 759417
SGTC_500 h-89 112 µM 0.196032058707162 0.42643966377754 no 1425 0.422292536781877 2070 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_470 aa-861 153 µM 0.19561783187587 0.426594722977169 no 1426 0.422454651055739 1918 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_399 oxolinic acid 75 µM 0.195492605724257 0.426641601621893 no 1427 0.422503662893698 1939 4628 A DNA gyrase inhibitor.
SGTC_292 k038-0015 474 µM 0.195296065219079 0.426715179017958 no 1428 0.42258058863327 2036 46368540
SGTC_1857 st056007 79.3 µM 0.192544510828257 0.427745524445173 no 1429 0.423657852757889 2065 619834
SGTC_2699 st077704 54.6 µM 0.191936444218285 0.427973287456113 no 1430 0.42389599488858 1973 645852
SGTC_2862 9027634 71.43 µM 0.190948933830272 0.428343229517249 no 1431 0.424282800895131 1870 5012562
SGTC_2066 5222451 176 µM 0.1904090479926 0.428545508701918 no 1432 0.424494304051434 2035 2281147
SGTC_2351 9026858 72.31 µM 0.189110844107796 0.429031983875713 no 1433 0.425002971236133 1944 1409300
SGTC_1982 st072467 71.9 µM 0.188924626526344 0.429101773939339 no 1434 0.425075945979212 1935 3163533
SGTC_2319 6033012 152.6 µM 0.187805632660134 0.429521193686684 no 1435 0.425514510057708 1950 847246
SGTC_1736 st036774 51 µM 0.187785881566169 0.429528597480641 no 1436 0.425522251877103 2116 1272247
SGTC_913 3487-1245 167 µM 0.186345246464529 0.43006869325405 no 1437 0.426087013626015 1951 4016153
SGTC_1620 st003704 16.5 µM 0.185929718603615 0.430224499495356 no 1438 0.426249938230502 2080 2834414
SGTC_2721 ifenprodil 61.44 µM 0.185325426817826 0.430451104002198 no 1439 0.426486897868913 2056 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_515 4092-1064 102 µM 0.184851176563023 0.430628960037781 no 1440 0.426672883192308 2097 717353
SGTC_2491 paeonol 100 µM 0.184141124016517 0.430895274290169 no 1441 0.426951372873757 1949 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2666 tannic acid 100 µM 0.183849409784436 0.431004694543358 no 1442 0.427065796662406 2029 16134267 A thiamine antagonist.
SGTC_1661 st013063 9.66 µM 0.183452488448634 0.431153585852175 no 1443 0.42722149738805 1981 721395
SGTC_1821 st053465 65.6 µM 0.183228869991579 0.431237472891208 no 1444 0.427309221416398 1964 675086
SGTC_606 k015-0008 38.6 µM 0.181707585924381 0.431808241447164 no 1445 0.42790610618941 2069 1970475
SGTC_167 3672-0051 66.205 µM 0.180429817032441 0.432287755940013 no 1446 0.42840757391347 2001 3237971
SGTC_558 k064-0027 21.3 µM 0.179788897123457 0.432528314657042 no 1447 0.428659150198089 2033 5088526
SGTC_1574 spiramycin 23.7 µM 0.179734612528228 0.432548690634703 no 1448 0.42868045952397 2043 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2127 5253358 187.912 µM 0.178577828935684 0.432982937339635 no 1449 0.42913460228714 1969 20612
SGTC_2830 7992007 71.43 µM 0.17849289691575 0.433014823292067 no 1450 0.429167949533453 1897 1952075
SGTC_653 0203-0016 55.2 µM 0.178364978519928 0.43306284840423 no 1451 0.429218175670585 2027 295302
SGTC_590 k048-0076 22.4 µM 0.177865251522068 0.43325047314842 no 1452 0.429414400463496 2094 6832814
SGTC_1387 3342-1166 1.8 µM 0.177233020054007 0.433487868844564 no 1453 0.42966267997571 1995 3418228
SGTC_1250 0485-0349 40.2 µM 0.177206678439943 0.433497760341184 no 1454 0.429673025024235 1977 6842794 YDL195W SEC31
SGTC_1547 harmine 94.2 µM 0.176857753300474 0.433628788580234 no 1455 0.429810061708488 2042 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_834 0312-0008 75.7 µM 0.175747711946844 0.434045679345959 no 1456 0.430246074961376 2010 6385573 YIL048W NEO1
SGTC_156 3474-0145 5.642 µM 0.174737583627783 0.434425110219656 no 1457 0.430642917305256 2126 2265471
SGTC_1840 st055363 71 µM 0.174544617912606 0.434497600121827 no 1458 0.430718734433986 1929 676033
SGTC_3243 9134147 49.47 µM 0.174248654067398 0.434608786794362 no 1459 0.430835024969029 2108 24282180
SGTC_2818 7996756 12.99 µM 0.174225354547186 0.434617540097162 no 1460 0.430844180104436 2010 2241621
SGTC_1494 4358-1428 177 µM 0.173183575258912 0.43500895464854 no 1461 0.431253566804699 2143 1564571
SGTC_2982 9019404 25.97 µM 0.170553455991283 0.435997418640396 no 1462 0.432287449154323 1806 22333232
SGTC_1288 0973-0013 65.5 µM 0.170264578050061 0.436106010614128 no 1463 0.432401033545707 2031 4315430
SGTC_1565 sinapyl alcohol 95.1 µM 0.170249043788773 0.43611185022767 no 1464 0.43240714164575 1955 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2309 7664088 163.95 µM 0.169414962444378 0.43642541710961 no 1465 0.432735127643226 2138 704922
SGTC_529 4076-0302 30.3 µM 0.16847688394956 0.436778128703064 no 1466 0.433104063831424 1970 5816522
SGTC_2200 6600604 21.907 µM 0.165158258866225 0.438026312377766 no 1467 0.43440970930628 2073 2904777
SGTC_2236 dapsone 200 µM 0.165020192447951 0.438078254637775 no 1468 0.434464044334236 2126 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_711 k292-0785 179 µM 0.164063756526982 0.438438106669457 no 1469 0.434840476624988 2072 4146315
SGTC_1949 st076024 69.1 µM 0.163957451587679 0.438478106275332 no 1470 0.434882319581399 2058 2921930
SGTC_609 0986-0026 86.3 µM 0.163076509335025 0.43880960460331 no 1471 0.435229097513573 2033 2848610
SGTC_763 3453-1109 128 µM 0.162789640965189 0.438917562368909 no 1472 0.435342032390119 2129 1560353
SGTC_819 1013-0258 27.7 µM 0.160481432941481 0.439786379764675 no 1473 0.43625092321503 2016 5753198
SGTC_2369 9071472 200 µM 0.159659515409426 0.440095822586373 no 1474 0.436574646866756 2043 17296037
SGTC_1292 0kpi-0043 232 µM 0.159346265772543 0.440213767236846 no 1475 0.436698035785917 2008 3333905
SGTC_1774 st048371 48.465 µM 0.158943266644124 0.440365512137995 no 1476 0.436856786054734 1960 4242727
SGTC_630 4356-0227 183 µM 0.157193536155226 0.441024455247274 no 1477 0.437546161186655 2100 779312
SGTC_1851 st056236 18.9 µM 0.156863233215073 0.441148864695782 no 1478 0.437676318359151 2158 5393171
SGTC_2038 4100038 30.985 µM 0.155148725602042 0.441794731421887 no 1479 0.438352034870897 2052 3596803
SGTC_2815 7968870 71.43 µM 0.153348385642304 0.442473098354228 no 1480 0.439061772822085 2046 2977326 YHR190W ERG9
SGTC_1022 4477-0945 21.3 µM 0.153044032729903 0.442587795059994 no 1481 0.439181775594733 1976 4648966
SGTC_1260 0700-1617 7.75 µM 0.153035196382011 0.442591125147682 no 1482 0.4391852597463 2035 2853078
SGTC_562 3772-2733 112 µM 0.150378276820686 0.443592601265857 no 1483 0.440233089479667 2126 2876874 YIL048W NEO1
SGTC_3037 9091026 49.47 µM 0.149402272698832 0.44396057860383 no 1484 0.440618109252269 2135 25236398 YIL048W NEO1
SGTC_2098 5376439 882.5 nM 0.148439043777501 0.444323786756082 no 1485 0.440998144440169 2103 2844116
SGTC_2159 5658611 73.75 µM 0.14523890119714 0.445530809967161 no 1486 0.44226112641625 2153 793844
SGTC_1801 st050089 28.441 µM 0.143748587343965 0.446093096544139 no 1487 0.442849501223186 2127 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2124 5246320 200 µM 0.14219921548102 0.446677780300358 no 1488 0.443461325724384 2065 579342
SGTC_2836 9010338 19.48 µM 0.140492765859814 0.447321874329407 no 1489 0.444135333905876 1954 2994051
SGTC_1976 st070609 63.5 µM 0.139830897928276 0.447571731785635 no 1490 0.444396800052364 2154 682556
SGTC_3343 9148379 18.9835 µM 0.139053019409159 0.447865410232788 no 1491 0.444704126269218 2170 1955036
SGTC_3092 9117248 49.47 µM 0.137609325654638 0.448410534638766 no 1492 0.44527459242318 2142 17141857
SGTC_1937 st074714 47.2 µM 0.137409186130277 0.448486113045413 no 1493 0.445353685220487 2092 17250970
SGTC_1676 st018489 23.4 µM 0.137048005852516 0.448622509774603 no 1494 0.445496424941031 2003 3696235
SGTC_1522 st012842 45.6 µM 0.137025859083503 0.448630873515574 no 1495 0.445505177652405 1974 3491067 YOR116C RPO31
SGTC_2016 5121758 140 µM 0.136137947271115 0.448966212725546 no 1496 0.445856114594126 2170 2795203
SGTC_1356 1502-0781 85.8 µM 0.136098527233943 0.448981101407082 no 1497 0.445871695896415 2043 567702
SGTC_2775 cyproheptadine 69.59 µM 0.135257059722042 0.449298935098754 no 1498 0.446204317198389 2180 2913 A selective serotonin reuptake inhibitor.
SGTC_732 3970-1727 52.7 µM 0.134729778988541 0.44949811277654 no 1499 0.446412763810542 2167 1275699
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.134233220014958 0.449685697097544 no 1500 0.446609078921045 2079 15053
SGTC_1802 st050112 57.9 µM 0.133851397142647 0.449829945386943 no 1501 0.446760041895824 2163 4662563
SGTC_576 1073-0113 22.7 µM 0.132341874781604 0.450400290302367 no 1502 0.447356943676789 2191 5439563
SGTC_2993 9054257 71.4286 µM 0.131285811482195 0.450799365132971 no 1503 0.447774607718586 2154 6470217 YGL055W OLE1
SGTC_1731 st035964 63 µM 0.131102414330591 0.450868674001732 no 1504 0.447847145644884 1980 6739575
SGTC_2074 5212007 75.395 µM 0.130104704922301 0.451245751359839 no 1505 0.448241793886656 2188 758611
SGTC_641 4092-0595 30 µM 0.129724671341537 0.451389394008658 no 1506 0.448392131296513 2140 786260
SGTC_1995 st072814 61.1 µM 0.129158991993843 0.451603217633792 no 1507 0.448615921999623 2014 5769371
SGTC_872 0588-0139 234 µM 0.128242849676121 0.451949544057328 no 1508 0.448978395435108 2196 2047100
SGTC_1770 st043884 66.3 µM 0.127404250673934 0.452266589086761 no 1509 0.449310226053401 2182 670149
SGTC_1438 4092-1045 4 µM 0.126421214149413 0.452638279646554 no 1510 0.449699255205519 2170 1351342
SGTC_2082 5219693 150 µM 0.125652717302012 0.452928880707032 no 1511 0.450003415621053 2141 2834649
SGTC_1227 3909-8010 46.6 µM 0.124600408096677 0.453326844054312 no 1512 0.450419952650781 2094 15982272
SGTC_3079 9117512 49.47 µM 0.1243207160841 0.453432626161103 no 1513 0.450530672739207 2198 7185044
SGTC_3269 9137823 49.47 µM 0.123707739595923 0.453664471085638 no 1514 0.450773341713004 2033 17682936
SGTC_649 1123-0311 367 µM 0.122965140664364 0.453945364006026 no 1515 0.451067351074423 2188 693629 YIL048W NEO1
SGTC_704 1310-0270 142 µM 0.121945587838548 0.45433105405505 no 1516 0.451471055572572 2063 5718033
SGTC_742 0kpi-0133 140 µM 0.121804083145381 0.454384587750348 no 1517 0.451527090074788 2182 2728852
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.121561695577032 0.454476289122953 no 1518 0.451623075472122 2114 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1990 st072050 59.8 µM 0.12130335779433 0.454574027537772 no 1519 0.451725380262506 2065 17233948
SGTC_1506 4226-2149 212 µM 0.121107238091093 0.454648228466659 no 1520 0.451803048105195 2096 991114
SGTC_1237 0330-0133 46.1 µM 0.120076834854586 0.455038102422993 no 1521 0.452211141354266 2118 X1237 YHR072W ERG7
SGTC_173 1273-0061 2.693 µM 0.119225975719053 0.455360074894189 no 1522 0.452548163888196 2055 2847414 YPL266W DIM1
SGTC_1588 farnesol 29.9 µM 0.118863932371716 0.455497084140057 no 1523 0.452691578462877 2110 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2100 5377183 190 µM 0.11823988115796 0.455733258293827 no 1524 0.452938795492143 2149 2844202
SGTC_1271 0832-2808 169 µM 0.117635713968286 0.455961922180316 no 1525 0.453178152873246 2191 3663794
SGTC_821 1114-0266 29.2 µM 0.117481014401432 0.456020474885327 no 1526 0.453239444083213 2115 3123235
SGTC_1814 st052110 31.539 µM 0.116763087629237 0.456292217633239 no 1527 0.453523897707772 2190 674163
SGTC_1740 st038286 13.222 µM 0.116513947920627 0.456386524388215 no 1528 0.453622616271411 2146 716786
SGTC_1269 0831-0796 3.05 µM 0.112911702231858 0.457750352940726 no 1529 0.455050279312619 2196 927758
SGTC_163 TUB2.036 7.546 µM 0.112797214273008 0.457793706908955 no 1530 0.455095663468578 2227 15992207 YJR013W GPI14
SGTC_1054 3429-0080 167 µM 0.110879026234542 0.45852015508575 no 1531 0.455856138836835 2180 1162877
SGTC_2004 4023728 41.89 µM 0.11077542722554 0.458559393636074 no 1532 0.455897215817909 2218 360084 YDR527W RBA50
SGTC_1343 1487-0095 224 µM 0.106807173130469 0.460062686588814 no 1533 0.45747097834814 2223 4560101 YGL055W OLE1
SGTC_2329 6138490 200 µM 0.106343304670891 0.460238451482615 no 1534 0.457654987102939 2078 720019
SGTC_2627 acetyl isogambogic acid 100 µM 0.1058847776274 0.460412200091012 no 1535 0.45783688592973 2099 6857789 A caspase activator and apoptosis inducer.
SGTC_31 0508-1974 57.237 µM 0.105756469776068 0.460460820847884 no 1536 0.457887787558821 2196 6810525
SGTC_788 1182-0090 188 µM 0.105061900494347 0.460724029982237 no 1537 0.458163345470899 2204 5715185
SGTC_2479 5617353 43.85 µM 0.104257602483712 0.461028842645042 no 1538 0.458482461405733 2175 2731746
SGTC_253 dyclonine 31.25 µM 0.103390579279961 0.461357452526975 no 1539 0.458826494361548 2206 3180 An oral anasthetic.
SGTC_2583 asiatic acid 100 µM 0.103368559071325 0.461365798735972 no 1540 0.458835232335987 2169 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2756 carbadox 75.1 µM 0.103206148578875 0.461427356893914 no 1541 0.458899680056554 2119 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_356 1634-0012 32.5 µM 0.102166266579812 0.461821523344373 no 1542 0.45931235149049 2245 735457
SGTC_757 1066-0008 322 µM 0.101774586717525 0.461969999030591 no 1543 0.459467798874024 2189 6842497
SGTC_428 3448-4153 16.5 µM 0.101629927171164 0.462024837057344 no 1544 0.459525211992203 2099 3834874
SGTC_2273 7815444 169.05 µM 0.101352623114306 0.462129960428114 no 1545 0.45963527200705 2246 2824616
SGTC_152 4469-0003 551.229 µM 0.100970750107609 0.462274729236814 no 1546 0.45978683975823 2250 697280
SGTC_1396 3511-0007 98.6 µM 0.0997372746312298 0.46274237626471 no 1547 0.460276453596178 2146 X1396
SGTC_3233 9132340 49.47 µM 0.0981991608600648 0.463325592754655 no 1548 0.460887074390883 2148 17682950
SGTC_1082 camptothecin 424.86 nM 0.097590290432093 0.463556483919911 no 1549 0.461128817407221 2221 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2752 diclazuril 33.15 µM 0.0971865089721758 0.46370960959733 no 1550 0.461289140803279 2215 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1901 st060216 58.6 µM 0.0970869220453429 0.463747376684802 no 1551 0.461328683246024 2232 688792
SGTC_561 1550-0330 72.9 µM 0.0967849344031508 0.463861903689876 no 1552 0.461448594182667 2129 6812934
SGTC_143 4032-1194 15.74 µM 0.0962382712940562 0.464069230011422 no 1553 0.46166566788416 2163 1806963
SGTC_2890 9046729 58.44 µM 0.0957399823904826 0.464258218533526 no 1554 0.461863542689962 2114 903329
SGTC_35 0133-0054 64.071 µM 0.0955519985067618 0.464329518217711 no 1555 0.461938195160759 2158 99677
SGTC_1049 3226-0134 66 µM 0.0935515579997673 0.465088328103689 no 1556 0.462732695943319 2224 5702385
SGTC_1466 k213-0079 57.5 µM 0.093087858832549 0.465264237346828 no 1557 0.462916881400484 2195 3657981
SGTC_1625 st003711 30.1 µM 0.0929242383716805 0.465326310142255 no 1558 0.46298187481086 2207 24207034 YER133W GLC7
SGTC_764 1951-2361 146 µM 0.0928642298458267 0.465349075825353 no 1559 0.463005711678604 2086 5438930
SGTC_2832 7992762 51.95 µM 0.0928515851136419 0.465353872924264 no 1560 0.463010734495302 2039 2985177
SGTC_2145 5634607 200 µM 0.0926586594820523 0.46542706476528 no 1561 0.463087370307909 2171 308662
SGTC_2362 9071156 126 µM 0.0921708458674837 0.465612135985293 no 1562 0.463281150523836 2220 653133
SGTC_1960 st011366 51.8 µM 0.0918076540524109 0.465749931872143 no 1563 0.463425431346976 2237 3972846
SGTC_2027 5150920 200 µM 0.0915755704507815 0.465837987124985 no 1564 0.46351763091518 2214 786715
SGTC_432 NS 1619 61.3 µM 0.0913019807313137 0.46594179243556 no 1565 0.463626322084178 2110 4552 A K+/calcium channel activator.
SGTC_3071 9117417 49.47 µM 0.0905186995960572 0.466238997464949 no 1566 0.463937517411412 2244 45595590 YGL055W OLE1
SGTC_1104 tacrolimus 29.8 µM 0.0901825491938641 0.466366550799116 no 1567 0.464071075770606 2242 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0897746982886754 0.466521315753464 no 1568 0.464233127412688 2266 1273210
SGTC_674 0498-0004 451 µM 0.0890597250760701 0.466792634933213 no 1569 0.464517222445254 2112 4231473
SGTC_330 1488-0319 80.1 µM 0.0880952516383554 0.467158659283623 no 1570 0.464900485175834 2144 6846614
SGTC_3 0833-0587 95.581 µM 0.0878481956464155 0.467252423224449 no 1571 0.464998665610038 2178 5382644
SGTC_2959 9079155 11 µM 0.0875166160070953 0.467378268862971 no 1572 0.465130439220796 2173 16189457
SGTC_346 4513-0042 7.16 µM 0.0870214404092372 0.467566210743535 no 1573 0.46532723488597 2239 2827372
SGTC_2450 5739737 12.93 µM 0.0853523880560964 0.468199745778615 no 1574 0.465990621899458 2163 2262825
SGTC_2094 5332512 191.667 µM 0.0850993128489722 0.468295814552883 no 1575 0.466091218296996 2232 755774
SGTC_132 0417-1715 25.805 µM 0.0840355535699719 0.46869964369308 no 1576 0.466514082036098 2270 6769098
SGTC_1289 0976-0073 69.1 µM 0.0827292862117777 0.469195578868136 no 1577 0.467033398828227 2198 3391136
SGTC_2233 sulbentine 40.3845 µM 0.082011138676334 0.469468249913988 no 1578 0.467318927956271 2228 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2199 6590217 200 µM 0.079923451875446 0.470260997622952 no 1579 0.468149068796243 2223 703109
SGTC_3123 9126162 49.47 µM 0.0789610415506694 0.470626489157271 no 1580 0.468531805305073 2263 25239884
SGTC_782 0083-0095 30.5 µM 0.0780977526359362 0.470954358728842 no 1581 0.468875147436388 2303 3591729 An indicator and reagent.
SGTC_1880 MG-132 525 µM 0.0778612586487639 0.471044180519645 no 1582 0.468969208468204 2271 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1720 st037298 9.481 µM 0.0778554007493947 0.471046405402585 no 1583 0.468971538359417 2187 597396
SGTC_2403 6032726 181.2 µM 0.0777856529807987 0.471072896302703 no 1584 0.468999279565114 2205 2881040
SGTC_708 3448-5400 146 µM 0.077454762284022 0.471198573640888 no 1585 0.469130888789896 2272 3462195
SGTC_157 1348-1695 65.819 µM 0.0751128429950933 0.472088151609144 no 1586 0.470062464730171 2278 5380510
SGTC_1147 3809-1045 12.3 µM 0.0730683717680131 0.472864857945062 no 1587 0.470875855016153 2183 325925
SGTC_1893 st059353 36.1 µM 0.0715483576291752 0.47344238706782 no 1588 0.471480669659764 2134 3112488
SGTC_1111 tnp00062 510.699 nM 0.0710544497646989 0.47363005935586 no 1589 0.471677210156873 2260 676306
SGTC_3344 9148862 3.898 µM 0.0701182776919099 0.473985796697228 no 1590 0.472049759506446 2251 4905352
SGTC_408 cantharidin 100 µM 0.0694652196052286 0.474233965457098 no 1591 0.472309658243924 2189 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1306 1185-0270 9.02 µM 0.0686723711960222 0.474535269400018 no 1592 0.472625205431016 2268 1548076
SGTC_2394 5221648 200 µM 0.0669029098376258 0.475207765079015 no 1593 0.473329498257789 2238 788586
SGTC_2096 5468907 200 µM 0.0661571329869188 0.475491223852717 no 1594 0.473626362444248 2264 759785
SGTC_155 k072-0202 43.6 µM 0.0657814736373743 0.475634011133947 no 1595 0.473775903090017 2301 5857737
SGTC_1486 3970-0793 4.53 µM 0.0642544294622372 0.476214469241494 no 1596 0.474383819225382 2299 2844330
SGTC_2472 5377652 49.4 µM 0.0630538827804028 0.476670855037605 no 1597 0.474861798695211 2154 1610903
SGTC_975 1335-0046 28.5 µM 0.0626134250887084 0.476838301991205 no 1598 0.475037169360161 2235 16486740
SGTC_2902 5787006 60.46 µM 0.0607366615408447 0.47755182879815 no 1599 0.475784466938458 2259 591003
SGTC_2250 alverine citrate 130 µM 0.0605482273859343 0.477623473600433 no 1600 0.47585950318975 2274 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_433 pimozide 108 µM 0.0600052079593212 0.477829939780355 no 1601 0.476075743407501 2297 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_718 1130-0073 349 µM 0.0598633803152172 0.477883866295414 no 1602 0.476132222919484 2253 6740020
SGTC_318 1488-0629 67.2 µM 0.0597057899853627 0.477943786663577 no 1603 0.476194980111434 2213 3662576
SGTC_1359 1582-0056 520 nM 0.0594713524908593 0.478032927452358 no 1604 0.476288341239419 2259 3661189
SGTC_2204 7233102 200 µM 0.0586703254936414 0.478337512332247 no 1605 0.476607347717179 2255 2172480
SGTC_49 0717-0965 32.132 µM 0.0566163649334933 0.479118573777278 no 1606 0.477425399061533 2264 5889349 YGL099W LSG1
SGTC_2842 9000675 19.48 µM 0.0562078775632253 0.47927391929587 no 1607 0.477588102848975 2214 2989072
SGTC_1782 st039423 80.636 µM 0.0555852575705359 0.479510704331294 no 1608 0.477836104550385 2163 2068169
SGTC_1905 st060207 84.5 µM 0.0544434390455302 0.479944961509686 no 1609 0.478290935400191 2170 1948547
SGTC_1519 esterone 74 µM 0.0541400957431973 0.480060333258735 no 1610 0.47841177364604 2249 698 A steroid.
SGTC_1759 st043059 70 µM 0.0535558667586682 0.480282540060291 no 1611 0.478644509620177 2277 669426
SGTC_1166 k206-0078 225 µM 0.0533885840974626 0.480346165808216 no 1612 0.478711150406001 2299 5404595
SGTC_2161 5662504 8.5105 µM 0.0529917465663071 0.480497104459549 no 1613 0.478869241880641 2245 2859334
SGTC_3073 9114972 49.47 µM 0.0525028904679937 0.480683046561634 no 1614 0.479063996126432 2317 41905075
SGTC_189 3970-0742 2.116 µM 0.0516658716731543 0.481001426131069 no 1615 0.479397465681337 2325 2891807
SGTC_3064 1327-0027 10 µM 0.0503001846452201 0.481520922887129 no 1616 0.479941588316029 2265 16000455 YPR107C YTH1
SGTC_171 k064-0041 9.68 µM 0.0482603051098277 0.482296935418793 no 1617 0.480754394801843 2248 53325
SGTC_2337 9009472 200 µM 0.0482518541873151 0.482300150466741 no 1618 0.480757762308987 2302 5742383
SGTC_345 1362-0200 395 µM 0.0477007184243593 0.482509825661745 no 1619 0.480977380768254 2259 1419823
SGTC_1214 0358-0031 63.7 µM 0.0476022953439544 0.482547270446618 no 1620 0.481016601342677 2304 4301366
SGTC_2215 7188065 200 µM 0.0475914831840134 0.482551383911932 no 1621 0.481020909887229 2317 940217
SGTC_979 1426-2828 121 µM 0.0461659282893526 0.483093749611108 no 1622 0.481588999396158 2274 747872
SGTC_1526 st051518 75 µM 0.0451676901277933 0.483473557344909 no 1623 0.481986823748982 2166 673993
SGTC_1931 st074438 57.1 µM 0.0445932634878736 0.483692120906887 no 1624 0.482215756138991 2327 2787313
SGTC_925 2064-1272 59.6 µM 0.043790944593486 0.483997403368407 no 1625 0.482535522664512 2215 6815817
SGTC_1567 st069303 68.4 µM 0.0432007623122271 0.484221973814784 no 1626 0.48277074871015 2262 5581319
SGTC_2572 astragaloside iv 100 µM 0.0428185051378677 0.484367429288122 no 1627 0.482923106275183 2265 45006101 An anti-inflammatory agent.
SGTC_1608 st001473 40.5 µM 0.0392153027178731 0.485738609749293 no 1628 0.48435936660833 2284 7292267
SGTC_1704 st028805 70.8 µM 0.0382028517292257 0.486123923902079 no 1629 0.484762973603131 2264 2876101
SGTC_2814 7977482 42.97 µM 0.0377749466791151 0.486286778043183 no 1630 0.484933559882551 2325 6456762
SGTC_1465 k213-0056 144 µM 0.0368990128029794 0.486620152230696 no 1631 0.485282763440952 2263 24048857 YMR208W ERG12
SGTC_2788 5282734 71.43 µM 0.0357041647659384 0.487074917905048 no 1632 0.485759124834039 2336 743706
SGTC_3345 9148410 3.559 µM 0.0336051409505945 0.487873858145455 no 1633 0.486596011349776 2333 4903596
SGTC_193 1273-0060 1.558 µM 0.0296811053544673 0.489367570925777 no 1634 0.488160690512735 2357 2847393 YHR072W ERG7
SGTC_1631 benzylvanillin 81.9 µM 0.0287261081121563 0.489731120958184 no 1635 0.488541516847272 2314 75506
SGTC_2825 7998094 58.44 µM 0.028351517616202 0.489873723074271 no 1636 0.488690895988729 2327 2987815
SGTC_1176 0848-0131 83.3 µM 0.0272986487273902 0.490274544525366 no 1637 0.489110767313753 2340 6769040
SGTC_333 3486-0131 40.1 µM 0.0270561600593346 0.49036686004667 no 1638 0.489207470576065 2349 6744690
SGTC_1502 4534-4282 27.7 µM 0.0261575579061664 0.490708962663169 no 1639 0.489565834086484 2343 3278949
SGTC_2560 caryophyllene 100 µM 0.0251981757461634 0.491074212088926 no 1640 0.489948446019576 2364 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_575 k072-0246 11.9 µM 0.0250730629891408 0.491121844721776 no 1641 0.4899983430232 2358 6796779
SGTC_1190 1486-1332 13 µM 0.0243486268567881 0.491397652799755 no 1642 0.49028726299506 2344 4150046
SGTC_2694 st077685 81.9 µM 0.0242373728825617 0.49144000989618 no 1643 0.490331633814571 2351 2838096
SGTC_1651 st011928 86.1 µM 0.0233441509512316 0.491780084688517 no 1644 0.490687876965779 2349 720198
SGTC_1470 k295-0292 231 µM 0.0233199563517339 0.491789296339445 no 1645 0.490697526587565 2362 5045612
SGTC_1993 st073995 70.8 µM 0.0231370532630893 0.491858933484122 no 1646 0.490770474680023 2288 3098394
SGTC_3334 9142812 21.919 µM 0.0228548189662328 0.491966389731116 no 1647 0.490883040106675 2336 45283678
SGTC_509 pifithrin 175 µM 0.0226632925533115 0.492039310717736 no 1648 0.49095942830435 2371 4817 A p53 inhibitor.
SGTC_1326 1431-2094 10.8 µM 0.0220825972425725 0.49226040390198 no 1649 0.491191034240307 2361 616278
SGTC_2040 5100729 123 µM 0.0219781364531826 0.492300176422615 no 1650 0.49123269795412 2356 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2231 micatex 6.853 µM 0.020954819568012 0.492689799252544 no 1651 0.49164084825742 2328 20737 An antifungal of unknown mechanism.
SGTC_3040 9091894 49.47 µM 0.0203479681631321 0.492920858234037 no 1652 0.491882895317407 2343 25236966
SGTC_549 1661-1316 519 µM 0.0198913337646667 0.493094723584101 no 1653 0.492065029216394 2369 2857282
SGTC_2742 clothiapine 36.27 µM 0.0177192416284985 0.493921773635541 no 1654 0.492931415228734 2373 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3102 9121669 49.47 µM 0.0167312522300127 0.494297971270632 no 1655 0.493325507486629 2309 41905072
SGTC_1921 5740136 50 µM 0.0161523632764382 0.494518397729351 no 1656 0.493556419548954 2366 1774243
SGTC_1988 st071872 53.4 µM 0.0155961121685903 0.494730205839293 no 1657 0.493778303673325 2389 16414116
SGTC_1395 3486-0190 4.35 µM 0.0153904150070179 0.494808531145011 no 1658 0.493860355119435 2384 6748079
SGTC_1490 4089-0339 670 nM 0.0150575855987345 0.494935266253464 no 1659 0.493993119455648 2386 742542
SGTC_400 oxethazaine 37.5 µM 0.0145738061832938 0.495119481161736 no 1660 0.494186098335912 2314 4621 A local anesthetic.
SGTC_1711 st032263 62.8 µM 0.0143417368305586 0.49520784956482 no 1661 0.494278670936896 2349 3958979
SGTC_3140 9094243 49.47 µM 0.0141100755515166 0.495296062814317 no 1662 0.494371081064343 2387 19291112
SGTC_1028 k015-0029 4.8 µM 0.0119871703906404 0.496104444423152 no 1663 0.495217925433584 2390 4588309
SGTC_1554 st069299 38.7 µM 0.011807648664943 0.496172805327811 no 1664 0.495289539171536 2355 24207999
SGTC_2587 piperic acid 92.2 µM 0.0115567117859939 0.496268360925447 no 1665 0.495389641671104 2371 5370536
SGTC_396 dithiazanine 1.25 µM 0.0105468522165059 0.496652912866303 no 1666 0.495792492730279 2375 10578 An antihelmenthic.
SGTC_2474 5321570 43.32 µM 0.00827139134847602 0.497519413396398 no 1667 0.496700229899521 2374 2841384
SGTC_2765 myclobutanil 7.74 µM 0.00816533197327924 0.497559801358127 no 1668 0.496742540039631 2376 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3333 9141820 12.094 µM 0.00783454925771542 0.4976857652955 no 1669 0.496874499027202 2388 1939433
SGTC_1852 st056254 31.4 µM 0.00751108112527034 0.49780894402128 no 1670 0.497003540342512 2348 442583
SGTC_1553 gossypol 38.6 µM 0.00718864313073018 0.497931730671887 no 1671 0.497132171016393 2390 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0066313328020174 0.498143958810584 no 1672 0.497354500358997 2395 6710655
SGTC_2279 7948423 32.93 µM 0.00650389208911336 0.498192489308286 no 1673 0.49740534075111 2389 1247112
SGTC_756 0508-1999 28.3 µM 0.00561029622899279 0.498532778855059 no 1674 0.497761827369923 2391 6753853
SGTC_1996 st072960 66.8 µM 0.00349468822945365 0.499338425702952 no 1675 0.49860582394626 2397 1719405
SGTC_1084 voriconazole 435 nM 0.00320385791935278 0.49944917737584 no 1676 0.498721847802214 2402 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2873 9040596 71.43 µM 0.00318614333411899 0.499455923303982 no 1677 0.498728914863173 2379 6463863
SGTC_1077 5-fluorocytosine 377 nM 0.00199067952961976 0.499911170628851 no 1678 0.499205834293426 2398 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1656 st012921 11 µM 0.00152415395597927 0.499911170628851 no 1679 0.49939195078054 2401 6732821
SGTC_1267 0828-0272 9.49 µM 0.00145925592099163 0.499886456650353 no 1680 0.499417841321801 2401 745334
SGTC_3197 9113331 49.47 µM 0.00138180406399545 0.499856962020949 no 1681 0.499448740111069 2401 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1455 4262-0120 131 µM 0.00103694750306694 0.499725636369805 no 1682 0.499586317872606 2397 1529587
SGTC_2415 st077333 57.7 µM 0 0.4993307541494 no 1683 0.5 2406 2766255
SGTC_519 k048-0011 62.8 µM -3.61403132849426e-05 0.499316991488147 no 1684 0.499985582101007 2408 6836379
SGTC_1316 1272-0050 65.9 µM -0.00104605080880186 0.498932405944959 no 1685 0.499582686181027 2409 7340392
SGTC_2696 st077691 74.316 µM -0.0013157141456675 0.498829715194864 no 1686 0.499475106149812 2408 757133
SGTC_2851 9015922 71.43 µM -0.00289601333454865 0.498227921747943 no 1687 0.498844659451195 2413 2996893
SGTC_1516 st013856 110 µM -0.00360478471531291 0.497958015875311 no 1688 0.498561902079872 2432 5281404 A mutagen and neurotoxin.
SGTC_682 0kpi-0099 17 µM -0.00384863542614777 0.497865155762807 no 1689 0.498464620396999 2420 1714895 YML126C ERG13
SGTC_752 1896-0090 130 µM -0.00477519020254068 0.497512318107155 no 1690 0.498094981971094 2417 772567
SGTC_3018 9082602 49.47 µM -0.00491845244730612 0.497457763145739 no 1691 0.498037829275831 2398 17332089
SGTC_29 0299-0004 12.984 µM -0.0051953752140256 0.497352309741443 no 1692 0.497927354488695 2416 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1735 st034310 56.75 µM -0.00536323502259324 0.497288388079607 no 1693 0.497860389047161 2484 871153
SGTC_727 3032-0951 202 µM -0.00572523463572378 0.497150537471314 no 1694 0.497715974316349 2425 3652836
SGTC_2242 6630449 61.2675 µM -0.00593592951455513 0.497070304344438 no 1695 0.497631920649818 2474 691249 YDR170C SEC7
SGTC_684 1140-0066 328 µM -0.00675277292586231 0.496759249518679 no 1696 0.497306053843904 2424 6813534
SGTC_3022 9087993 49.47 µM -0.00738528170730197 0.496518390856557 no 1697 0.497053725657112 2420 17173644
SGTC_2762 leflunomide 42.06 µM -0.00854183842656104 0.496077978649311 no 1698 0.496592340938178 2423 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3249 9135183 49.47 µM -0.00972382735902223 0.495627886899172 no 1699 0.496120815270566 2454 4902779
SGTC_2689 tacrolimus 100 µM -0.00996106146526275 0.495537550737625 no 1700 0.49602617713954 2427 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_304 1310-0298 97 µM -0.0106117320577705 0.495289783657331 no 1701 0.495766610866865 2435 1550234
SGTC_1378 2093-0007 380 nM -0.0116539060208692 0.494892940901997 no 1702 0.495350869392492 2435 3618014
SGTC_2229 7354935 190 µM -0.0130927948210102 0.494345044029875 no 1703 0.494776879803359 2424 318112
SGTC_2715 st079500 56.4 µM -0.014856605451178 0.493673438805796 no 1704 0.494073289965732 2427 28246688
SGTC_2781 5567276 71.43 µM -0.015218944957007 0.493535473145122 no 1705 0.493928753761036 2451 2853274
SGTC_3132 9126706 49.47 µM -0.01595076836056 0.493256823875253 no 1706 0.493636833924115 2475 850858
SGTC_453 enantio-paf c16 10 µM -0.0163408552900128 0.493108295610039 no 1707 0.493481232038946 2440 13871343 A lipid and platelet activating factor
SGTC_2571 chrysanthemic acid 100 µM -0.0165207454782047 0.493039801511722 no 1708 0.493409475923839 2460 2743 An insecticide.
SGTC_2496 diffractaic acid 79.83 µM -0.0167328901828927 0.492959026607088 no 1709 0.493324854129436 2432 94870 An apoptosis inducer which activates caspases.
SGTC_1807 st050092 58.9 µM -0.018554019725289 0.492265636815963 no 1710 0.492598441729055 2441 5008496
SGTC_2998 9066762 71.4286 µM -0.0186680537626853 0.492222219442693 no 1711 0.492552956608196 2460 4945196
SGTC_2797 7859098 81.82 µM -0.0189130073699262 0.492128956002772 no 1712 0.492455251508353 2449 972681
SGTC_1031 k035-0009 16 µM -0.0192073848421701 0.492016875529848 no 1713 0.492337833219147 2438 5180959
SGTC_858 0438-0351 2.77 µM -0.0198676495515827 0.491765490457354 no 1714 0.492074475983533 2445 2799119
SGTC_1523 st012844 44.7 µM -0.0201989638628903 0.491639349136366 no 1715 0.491942327217771 2501 4274103
SGTC_615 k087-0205 167 µM -0.0203165135248534 0.491594594645616 no 1716 0.491895441309006 2442 9642773
SGTC_46 0329-0187a 2.197 µM -0.0222864306518788 0.490844607501135 no 1717 0.491109736483232 2436 46494817
SGTC_2919 7978188 46.38 µM -0.0228216790418557 0.490640833134509 no 1718 0.490896257576207 2438 2980291
SGTC_995 3931-2021 34.6 µM -0.0233321108324847 0.490446508967878 no 1719 0.49069267897028 2462 730143
SGTC_181 1447-1644 8.07 µM -0.0239743788841601 0.490201997244949 no 1720 0.490436522760166 2440 534600
SGTC_1987 st072290 61.9 µM -0.024570115103885 0.489975203499968 no 1721 0.490198928396379 2488 54697379
SGTC_165 k038-0023 64.381 µM -0.0246397154048783 0.489948707229871 no 1722 0.490171170297264 2452 46368543
SGTC_3149 9097855 49.47 µM -0.0247800546762128 0.489895281342502 no 1723 0.490115200118074 2465 25236625 YMR079W SEC14
SGTC_328 k915-0120 63.5 µM -0.0255129750424849 0.489616268176197 no 1724 0.48982289963465 2465 6624543
SGTC_540 1187-0821 17.3 µM -0.0263383791566693 0.489302053750952 no 1725 0.48949372168997 2454 847520
SGTC_2269 7935389 174.42 µM -0.0267689452978097 0.48913814867046 no 1726 0.489322011200031 2446 97605
SGTC_3300 9124615 50.48 µM -0.0269393285294592 0.489073288809956 no 1727 0.489254062629929 2485 24824903
SGTC_2411 st077133 39.94 µM -0.029227817750867 0.488202157294746 no 1728 0.488341447675116 2620 1403142 YNL221C POP1
SGTC_1423 4048-0112 5.59 µM -0.0293317662640503 0.488162589776304 no 1729 0.488299995990443 2465 X1423
SGTC_3033 9090887 49.47 µM -0.0295822708810712 0.488067236837521 no 1730 0.488200102456548 2447 19325384
SGTC_797 k781-0471 270 µM -0.0307651403700196 0.487616994633921 no 1731 0.48772842060354 2523 23738129
SGTC_27 0485-0001 32.618 µM -0.0309599279451886 0.487542853052094 no 1732 0.487650748604176 2455 2054479
SGTC_395 anisomycin 6.25 µM -0.0310489715032468 0.487508960734578 no 1733 0.487615242433796 2495 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2439 5492030 7.2 µM -0.0344791918002416 0.486203399776646 no 1734 0.486247517509601 2488 5722370
SGTC_1930 st074634 34.3 µM -0.0353385438433821 0.485876348214602 no 1735 0.48590489448518 2466 684253 YOR116C RPO31
SGTC_1107 amlodipine 47 µM -0.0353463226721929 0.485873387796766 no 1736 0.485901793119019 2494 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0365413402266485 0.485418604863221 no 1737 0.485425357985817 2459 5355888
SGTC_2277 7947813 106.88 µM -0.0392173969602993 0.48440025859063 no 1738 0.484358531768687 2656 1246798
SGTC_2355 9061122 103.12 µM -0.0410994390419662 0.483684127091746 no 1739 0.483608310903456 2504 5302957
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0415822937265126 0.483500405558762 no 1740 0.483415844295847 2460 279621
SGTC_153 4077-0274 519.67 µM -0.0421215368825699 0.483295232900762 no 1741 0.483200905727886 2490 3121976
SGTC_2421 5690543 90.72 µM -0.0427176187668169 0.483068439243157 no 1742 0.482963317322117 2510 3397993
SGTC_696 1560-0013 611 µM -0.0429913474225422 0.482964294438228 no 1743 0.482854215617348 2533 1650269
SGTC_1991 st073000 8.92 µM -0.0433927698699218 0.482811568424243 no 1744 0.482694220541207 2589 4301969 YIL048W NEO1
SGTC_1112 tnp00069 1.16933 µM -0.043396683718969 0.482810079365525 no 1745 0.482692660610789 2587 145826
SGTC_467 ro 31-8220 72.8 µM -0.0435781090681371 0.482741054739555 no 1746 0.482620350775209 2483 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2853 9015042 58.44 µM -0.0446304527985509 0.482340692993561 no 1747 0.482200934507063 2491 6457456
SGTC_1268 0828-0275 2.46 µM -0.0456432128709387 0.481955407569747 no 1748 0.48179731307677 2554 745337
SGTC_940 3232-1287 54.8 µM -0.046444345604222 0.481650643686855 no 1749 0.481478045973067 2484 1585493 YIL048W NEO1
SGTC_1718 roemerine 11.9335 µM -0.0478733101003257 0.481107069157257 no 1750 0.480908605224272 2492 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1842 st055362 61.2 µM -0.0486333361031707 0.480817971406916 no 1751 0.480605751509877 2511 676032
SGTC_84 0443-0269 128.823 µM -0.0513808018714512 0.479772979033201 no 1752 0.479511041225725 2489 6150058
SGTC_1710 st031758 61.5 µM -0.0519593381861125 0.479552951534364 no 1753 0.479280546524657 2613 5394341
SGTC_734 2023-0417 80 µM -0.0522981351123602 0.479424104014486 no 1754 0.47914556962506 2551 3935732
SGTC_3222 9128301 49.47 µM -0.0527682836434235 0.479245305862191 no 1755 0.478958266132363 2526 4911358
SGTC_2769 toremifene 3.73 µM -0.0534753914992221 0.478976399618596 no 1756 0.478676568663495 2581 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2904 7225135 42.03 µM -0.0541710218695083 0.478711867488049 no 1757 0.47839945398564 2543 4446116
SGTC_2105 5350118 200 µM -0.0550039677005309 0.478395129812554 no 1758 0.478067651406153 2523 2133313
SGTC_2655 perillic acid 100 µM -0.055443580694257 0.47822796717001 no 1759 0.477892538419027 2496 5702197 An apoptosis inducer.
SGTC_3250 9135583 49.47 µM -0.0557265235123169 0.478120380315101 no 1760 0.477779834810955 2610 7699353
SGTC_2532 xanthone 78.9 µM -0.0559218231881418 0.478046120028159 no 1761 0.477702042820609 2537 7020 An insecticide.
SGTC_1006 4099-6547 255 µM -0.0570974015931679 0.477599137068636 no 1762 0.477233803138393 2563 3146833
SGTC_2646 retinol 96.75 µM -0.0595231760972229 0.476676889413193 no 1763 0.476267703172664 2568 445354 A vitamin A analog and teratogen.
SGTC_212 3807-4682 38.772 µM -0.0595293811534315 0.476674530490259 no 1764 0.476265232095252 2579 3125501 YBL034C STU1
SGTC_960 1222-0186 7.7 µM -0.0595487131553213 0.47666718121435 no 1765 0.476257533399978 2575 3126296
SGTC_322 k048-0136 19.3 µM -0.060323415912271 0.476372675888128 no 1766 0.475949026350987 2590 6823282
SGTC_1675 st018485 24.5 µM -0.0626435097767207 0.475490763834812 no 1767 0.475025190821033 2590 3323024
SGTC_491 tetrandrine 80.3 µM -0.0635819669745886 0.475134072164539 no 1768 0.474651545477048 2570 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1196 1588-0294 184 µM -0.0648682845085165 0.474645197113227 no 1769 0.474139436342863 2584 6144269
SGTC_786 4544-0069 423 µM -0.0651477276655074 0.474538997575277 no 1770 0.47402818996732 2645 748821 YLR208W SEC13
SGTC_973 1325-0077 65.9 µM -0.0662497409716999 0.474120206301102 no 1771 0.473589498078537 2582 2835149
SGTC_228 caffeine 993.056 µM -0.0665521098475831 0.474005303914858 no 1772 0.473469135986044 2527 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1419 3993-2473 62.6 µM -0.0667145313976125 0.473943583429052 no 1773 0.473404482851935 2538 704026
SGTC_2819 7996655 46.38 µM -0.0672944531813502 0.47372321720506 no 1774 0.473173646300467 2549 6456960
SGTC_2790 5423970 71.43 µM -0.0710828281194519 0.472283862085158 no 1775 0.471665917385845 2608 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_487 nimodipine 119 µM -0.0719008960977813 0.471973092213646 no 1776 0.47134038845722 2515 4497 L-type voltage-gated calcium channels inhibitor
SGTC_864 0469-0573 172 µM -0.0721553761446364 0.471876423117175 no 1777 0.471239128618939 2527 689425
SGTC_1394 3474-0001 65.7 µM -0.0726002873570961 0.471707419096317 no 1778 0.471062099023756 2586 5017666 YIL048W NEO1
SGTC_2652 actinonin 100 µM -0.0733840912636108 0.471409695672025 no 1779 0.470750238396246 2529 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2321 7390090 138.78 µM -0.0752523497166843 0.470700113135063 no 1780 0.470006966671672 2601 649046
SGTC_2612 dictamnine 15.46 µM -0.0753329504421492 0.470669502280905 no 1781 0.469974902648593 2619 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_963 1269-2853 151 µM -0.0760880450844326 0.470382737968881 no 1782 0.469674525604597 2575 3668223
SGTC_2466 5983409 37.09 µM -0.0768104954104413 0.470108385451098 no 1783 0.469387150638701 2592 2879657
SGTC_1862 st057513 3.81 µM -0.0777494450477925 0.46975183794219 no 1784 0.469013680826652 2559 5393163
SGTC_2151 5563267 85.4165 µM -0.0778292212038455 0.469721545642399 no 1785 0.468981950892198 2591 5310824
SGTC_546 peri-Naphthalide 147 µM -0.0788966331347004 0.469316248955804 no 1786 0.468557420632329 2620 223824 A penicillin ester.
SGTC_170 4197-0004 226 µM -0.0789431605246229 0.469298583209499 no 1787 0.468538916603898 2634 218692
SGTC_1405 3909-7894 12 µM -0.0789902627616659 0.469280699263999 no 1788 0.468520184026941 2616 7104060
SGTC_1152 3909-8331 15.9 µM -0.0792627534438404 0.469177240246607 no 1789 0.46841181575182 2558 16001939
SGTC_1496 4469-0713 57.4 µM -0.0793619813754226 0.46913956599125 no 1790 0.468372353846526 2534 746691
SGTC_1941 st076221 61.8 µM -0.0799677752733522 0.468909567867218 no 1791 0.468131442735635 2679 2828568
SGTC_1634 st006576 41 µM -0.0802123647443607 0.468816708990358 no 1792 0.468034178103395 2573 3915356
SGTC_1657 st012939 43.4 µM -0.0804112161330422 0.468741215916944 no 1793 0.467955103304299 2620 24207257
SGTC_2910 7948405 25.97 µM -0.0807678878228828 0.468605809863543 no 1794 0.467813273206631 2586 2971328
SGTC_1446 4239-0190 62 µM -0.081397998301301 0.468366604996325 no 1795 0.467562720477197 2568 1340085
SGTC_1197 1601-0112 267 µM -0.0815310878512118 0.468316082507701 no 1796 0.467509801318609 2540 7350313
SGTC_1714 st033236 13.627 µM -0.0823956522613434 0.46798789530408 no 1797 0.467166046644314 2632 2916566
SGTC_421 streptovitacin 30 mM -0.0825175781245077 0.467941614195709 no 1798 0.467117570340348 2744 91467 include heat shock
SGTC_637 1181-0519 7.26 µM -0.08304603659623 0.467741024825638 no 1799 0.466907467050541 2554 6252091 YGR060W ERG25
SGTC_2885 9057732 51.95 µM -0.0839800140327866 0.467386530851653 no 1800 0.466536161058864 2647 6471414
SGTC_1776 st049249 45.9 µM -0.0848677195933194 0.467049623478553 no 1801 0.46618327760211 2578 1822314
SGTC_298 1391-0729 10 µM -0.0857161842027884 0.466727631127972 no 1802 0.46584601817325 2551 3237558
SGTC_79 0052-0007 94.094 µM -0.0864915110496982 0.466433413595464 no 1803 0.465537851992906 2576 2801472
SGTC_1789 tunicamycin 25 nM -0.0867930717102226 0.466318983662733 no 1804 0.465417997408493 2641 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_423 5-fluorouracil 457 µM -0.0872294713294136 0.466153392794345 no 1805 0.465244556950381 2549 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3085 9117376 49.47 µM -0.0882314981818592 0.465773198144669 no 1806 0.464846341501989 2638 16480349
SGTC_1004 4084-0029 199 µM -0.0883322360323458 0.465734977346584 no 1807 0.464806309218124 2609 716894 YLR208W SEC13
SGTC_1529 apigenin 74 µM -0.089407888465091 0.465326885431772 no 1808 0.464378877246235 2617 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2 0422-0095 29 µM -0.0908470867444994 0.46478092491637 no 1809 0.463807047451014 2497 6790840
SGTC_398 bronopol 33.3 µM -0.091142959209909 0.464668693745448 no 1810 0.463689499079956 2572 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1797 st048695 56.8 µM -0.0923397214909516 0.464214763300859 no 1811 0.463214064989633 2568 592262 YIL048W NEO1
SGTC_3235 9132602 49.47 µM -0.0929812595828628 0.463971447838668 no 1812 0.462959224701402 2656 4912240
SGTC_2680 butyl paraben 22.24 µM -0.0940990139951334 0.463547550568144 no 1813 0.462515251812666 2569 7184 An antifungal and steroid mimetic.
SGTC_724 3910-0327 137 µM -0.0944975070572807 0.46339643600973 no 1814 0.462356981332777 2610 2885483
SGTC_274 sirtinol 40.1 µM -0.0954291625942001 0.463043158872969 no 1815 0.461986976686057 2612 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_956 1185-0240 191 µM -0.096136825060747 0.462774837773017 no 1816 0.461705952287543 2626 1416193
SGTC_884 0851-0618 334 µM -0.0963305714661105 0.462701378793942 no 1817 0.461629015732786 2624 9642473
SGTC_347 4534-1311 26.2 µM -0.0972690830146609 0.462345560047139 no 1818 0.461256353864771 2556 2862016
SGTC_3107 9121808 49.47 µM -0.0975363758495213 0.46224422656904 no 1819 0.461150224090042 2573 662681
SGTC_1971 st069429 63.5 µM -0.0975618632807963 0.462234564148118 no 1820 0.46114010433973 2622 1246522 YGL099W LSG1
SGTC_715 0868-0130 184 µM -0.0976110409275113 0.46221592070336 no 1821 0.461120578492358 2636 2876258
SGTC_2354 9060492 162 µM -0.0984980858226076 0.461879652688744 no 1822 0.460768395931063 2666 6471895
SGTC_1317 1273-0028 910 nM -0.0986956407512926 0.461804765700885 no 1823 0.460689965072028 2601 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_3223 9129970 49.47 µM -0.100126413631535 0.461262444357108 no 1824 0.460121982827203 2613 17248386
SGTC_2676 harmalol 100 µM -0.100611990658875 0.461078407156939 no 1825 0.459929238920493 2584 5459187 A monoamine oxidase inhibitor
SGTC_1369 1866-0067 208 µM -0.101365305204429 0.460792912014445 no 1826 0.459630238507797 2581 3531355
SGTC_1299 1079-1439 3.74 µM -0.102306579156971 0.460436211435632 no 1827 0.459256666649755 2603 323161
SGTC_2057 5236571 38.335 µM -0.102712702412594 0.460282318764888 no 1828 0.459095495950752 2631 54684039 YBR257W POP4
SGTC_176 1486-1328 72.834 µM -0.104690702542253 0.459532878769834 no 1829 0.458310619857986 2657 22310231
SGTC_2751 anetholtrithion 17.25 µM -0.106704924367922 0.458769862575835 no 1830 0.4575115379171 2693 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1248 0469-0687 58.6 µM -0.107641523370868 0.458415116963464 no 1831 0.457140028722825 2684 4017482
SGTC_1453 4237-0541 195 µM -0.108024985433583 0.458269886668261 no 1832 0.456987936335514 2605 739892
SGTC_2088 5278280 127.392 µM -0.108334154680688 0.458152797677456 no 1833 0.456865315260985 2646 791502
SGTC_361 000s-0510 1.45 µM -0.10840831023428 0.458124713926575 no 1834 0.456835904687058 2657 660
SGTC_414 piperonyl butoxide 100 µM -0.110789823326689 0.457222913358945 no 1835 0.455891507739204 2601 5794 A potent inhibitor of cytochrome P450.
SGTC_2053 5265679 138 µM -0.111767535305345 0.456852749535653 no 1836 0.4555038646351 2614 764595
SGTC_1514 1189-1591 158 µM -0.112055025185015 0.456743912366893 no 1837 0.455389888731452 2793 767698 YMR146C TIF34
SGTC_1678 st019265 80.2 µM -0.113024107263771 0.45637706375172 no 1838 0.4550057214202 2648 5367020
SGTC_1539 benzyladenosine 56 µM -0.113112750897078 0.456343509318304 no 1839 0.454970583059073 2604 92208 A nucleotide analog.
SGTC_377 3970-0964 33.1 µM -0.113351040494737 0.456253310673688 no 1840 0.454876126742965 2602 16481235
SGTC_2619 obliquin 87.91 µM -0.115279784873723 0.455523315472231 no 1841 0.454111680431147 2625 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1787 fluconazole 80 µM -0.11564378867004 0.455385563321583 no 1842 0.453967428679814 2633 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_617 3770-0098 35 µM -0.116587531908612 0.45502844190086 no 1843 0.453593459217313 2629 5962639
SGTC_2656 pseudo-anisatin 100 µM -0.118085288349793 0.454461751331603 no 1844 0.453000040043234 2608 6708809 A neurotoxin.
SGTC_65 0798-0905 34.986 µM -0.118130221099748 0.454444752019195 no 1845 0.452982239060379 2907 3602145
SGTC_2435 5706476 10.6 µM -0.11842654702759 0.454332645747708 no 1846 0.452864846148325 2666 5725375
SGTC_583 1488-1091 88.9 µM -0.118822914302941 0.45418269743934 no 1847 0.452707827152364 2590 4303273
SGTC_1560 lithocholic acid 53.1 µM -0.118902843017119 0.454152460679375 no 1848 0.452676164670604 2612 9903 A bile acid which acts as a detergent.
SGTC_912 3474-0017 2.18 µM -0.118975581706448 0.454124944112211 no 1849 0.452647350663714 2759 3360550
SGTC_2003 4023581 200 µM -0.119526802567181 0.453916428056517 no 1850 0.45242900343325 2708 16641307
SGTC_2023 5144124 124 µM -0.119628179304522 0.45387808060341 no 1851 0.452388848081386 2642 2830192
SGTC_443 clozapine 122 µM -0.120137594739495 0.453685392177574 no 1852 0.452187075875948 2597 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2323 6148992 148.28 µM -0.120922584067105 0.453388488183852 no 1853 0.451876176965498 2679 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3259 9138485 49.47 µM -0.123572616401271 0.452386368345934 no 1854 0.450826837608675 2740 17646153
SGTC_1128 3448-9350 235 µM -0.1240109029047 0.452220657685031 no 1855 0.450653321216731 2735 619386
SGTC_1216 1165-0504 9.65 µM -0.124655976693023 0.45197677847816 no 1856 0.450397955485344 2638 6304004
SGTC_644 1498-1197 63.3 µM -0.125702794528017 0.451581052893368 no 1857 0.449983594851574 2712 6741615
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.126285718559493 0.451360712599143 no 1858 0.449752880344013 2655 688801
SGTC_1911 st060208 74.3 µM -0.126846614914436 0.451148712723377 no 1859 0.44953090016492 2735 688783
SGTC_931 2812-0076 566 µM -0.127365130560564 0.45095274371672 no 1860 0.449325706609329 2618 3450959
SGTC_1070 indatraline 8.81 µM -0.127638890778403 0.45084928296372 no 1861 0.449217376223211 2651 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_204 PMA1.184 62.41 µM -0.130594922244682 0.449732339757811 no 1862 0.448047879893242 2607 2252213 YGL008C PMA1
SGTC_54 0159-0055 9 µM -0.131009979977919 0.449575540922834 no 1863 0.447883706286451 2703 3319099
SGTC_1011 4112-3381 17.4 µM -0.132814035142614 0.448894104036979 no 1864 0.447170227129612 2821 2877139
SGTC_205 1486-1330 71.903 µM -0.133583231782702 0.448603604889514 no 1865 0.446866072217708 2630 4118834
SGTC_1179 1021-1431 9.29 µM -0.133906891063833 0.448481378124925 no 1866 0.446738100542396 2724 2840958
SGTC_2243 6634756 200 µM -0.135640164770252 0.447826907744936 no 1867 0.446052875983911 2927 885676
SGTC_3020 9089140 49.47 µM -0.135958945822781 0.447706553960164 no 1868 0.445926868006913 2702 17217859
SGTC_1687 st020778 55.3625 µM -0.136579332190758 0.447472344793556 no 1869 0.445681656956487 2665 4259299
SGTC_178 4092-0806 87.505 µM -0.137128736176741 0.447264948287712 no 1870 0.445464519418166 2642 2169044
SGTC_3225 9130819 49.47 µM -0.137441658426642 0.447146828572778 no 1871 0.445340852401156 2660 4547121
SGTC_2437 5741531 144.16 µM -0.137477157234568 0.447133429025492 no 1872 0.445326823591627 2779 2262990
SGTC_90 0870-0863 4.608 µM -0.138276198874731 0.446831834998693 no 1873 0.445011067671244 2630 1738164
SGTC_450 aminopyrene 156 nM -0.140363523577666 0.446044130873047 no 1874 0.444186388229412 2674 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_109 0132-0036 33.701 µM -0.140615814908964 0.445948936795968 no 1875 0.444086726944377 2630 67274 A color developer.
SGTC_717 1532-0246 73.2 µM -0.140635168300442 0.44594163454033 no 1876 0.444079082024364 2727 9561992
SGTC_2485 5633444 17.78 µM -0.14095147784975 0.44582228993541 no 1877 0.443954137303885 2745 5724239
SGTC_1223 0764-0573 147 µM -0.141071995357125 0.445776819585138 no 1878 0.443906533420432 2666 1609797
SGTC_987 1497-1013 404 µM -0.141708214572831 0.445536790687902 no 1879 0.443655243068266 2653 1676435
SGTC_1038 k292-0204 154 µM -0.142113438578081 0.445383920652518 no 1880 0.443495201732193 2643 4454212
SGTC_3179 9107801 49.47 µM -0.142316629949367 0.445307270124418 no 1881 0.443414955712833 2686 4818259
SGTC_2460 5552655 174.22 µM -0.142909841808044 0.445083502633922 no 1882 0.443180692860383 2773 5401989
SGTC_1336 1486-0901 104 µM -0.14382947208374 0.444736640339948 no 1883 0.442817564740967 2749 5006114
SGTC_2137 5261020 140 µM -0.143889533139235 0.444713988231814 no 1884 0.442793850510139 2650 763655
SGTC_738 1315-0003 72.4 µM -0.144061725718178 0.444649046569382 no 1885 0.442725863920799 2781 6251474
SGTC_844 0330-0132 15.3 µM -0.144063097702946 0.444648529137415 no 1886 0.442725322228469 2768 2828079
SGTC_281 1672-3440 14.9 µM -0.144821407240024 0.444362553835174 no 1887 0.442425939936932 2756 6833000
SGTC_596 1155-0152 116 µM -0.145026164916492 0.444285340145394 no 1888 0.442345106780993 2652 280313
SGTC_2584 androsterone 48.74 µM -0.148534426941433 0.442962712804764 no 1889 0.440960509254748 2722 2754130 A steroid.
SGTC_1173 0443-0020 122 µM -0.148993422009866 0.442789716704262 no 1890 0.440779411752723 2696 5331295
SGTC_830 4076-0286 57.8 µM -0.150579680599653 0.442191937055757 no 1891 0.440153645568939 2704 6866659
SGTC_2966 9084041 48.03 µM -0.152686244247825 0.441398284733271 no 1892 0.43932285453107 2641 17741380
SGTC_537 1334-0398 209 µM -0.152953505184205 0.441297610359125 no 1893 0.439217470620027 2670 5846986
SGTC_337 1315-0038 354 µM -0.153027762458268 0.44126963910072 no 1894 0.439188190928914 2703 1626437
SGTC_3133 9127736 49.47 µM -0.153658144094067 0.441032198517701 no 1895 0.438939644459661 2646 27243420
SGTC_780 0109-0199 192 µM -0.154128692330058 0.440854974856489 no 1896 0.438754132687805 2877 610414
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.155557227086355 0.4403170152439 no 1897 0.438191021125859 2807 6728940
SGTC_1013 4112-3890 241 µM -0.156367250689346 0.440012024297349 no 1898 0.437871774885974 2677 705171
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.156814025057353 0.439843819556449 no 1899 0.437695709604741 2808 521171
SGTC_2214 7179297 48.276 µM -0.157298994798415 0.439661247044936 no 1900 0.437504606216171 2676 769744
SGTC_1180 1193-0155 285 µM -0.157747803601748 0.439492299171365 no 1901 0.43732776511122 2811 2921347
SGTC_3276 9139060 49.47 µM -0.158438592396181 0.439232282817632 no 1902 0.437055602739572 2671 4870619
SGTC_3047 9092122 49.47 µM -0.158585068226541 0.439177151948379 no 1903 0.436997896869648 2736 17173831
SGTC_1091 telmisartan 47.6 µM -0.158640095230312 0.439156441078222 no 1904 0.436976218682954 2779 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1790 st045711 43.5 µM -0.159338852664326 0.438893459718081 no 1905 0.436700955881224 2755 585119
SGTC_2861 9024595 19.48 µM -0.161083513571137 0.438236964592765 no 1906 0.43601381246709 2747 16482810
SGTC_2459 5811157 9.22 µM -0.1617507620783 0.437985931748772 no 1907 0.435751064242285 2669 2870684 YBR192W RIM2
SGTC_367 0335-0881 7.1 µM -0.162612379687593 0.43766181011377 no 1908 0.435411819578467 2837 23828853
SGTC_795 0685-0265 78 µM -0.163194557006174 0.437442831446926 no 1909 0.435182625819352 2691 302754
SGTC_2446 5162541 200 µM -0.163317826532052 0.437396467622889 no 1910 0.435134099398985 2681 1549321
SGTC_3273 9137859 49.47 µM -0.164413914925735 0.436984247490549 no 1911 0.434702655054068 2699 2377234
SGTC_3346 9158254 43.5805 µM -0.16454707913596 0.436934171355899 no 1912 0.434650243997141 2791 17639500
SGTC_2379 9035213 200 µM -0.165105208126199 0.436724299068554 no 1913 0.434430586890052 2748 646551
SGTC_882 0843-0131 351 µM -0.165558245438841 0.436553957316416 no 1914 0.434252304517055 2691 5425421
SGTC_2706 st078239 82.5 µM -0.166651720722089 0.436142859806435 no 1915 0.433822047724612 2699 15434492
SGTC_1239 0337-0584 35.4 µM -0.166704655927977 0.436122960297454 no 1916 0.433801220952232 2859 914301 YML130C ERO1
SGTC_589 1227-0070 34.1 µM -0.167000252659991 0.436011841953723 no 1917 0.433684925061439 2812 2841384
SGTC_1113 artemisinin 1.17947 µM -0.167018148379093 0.436005114901124 no 1918 0.433677884577154 2737 2240 An anti-malaria and mitochondrial poison.
SGTC_893 0958-0369 48.9 µM -0.169203611797134 0.435183732640823 no 1919 0.432818244475606 2853 6819948
SGTC_2911 7942208 15.64 µM -0.173374237027346 0.43361702805403 no 1920 0.431178637153599 2807 1243384
SGTC_2457 5731572 11.68 µM -0.174070166791825 0.433355701323682 no 1921 0.430905159342908 2871 2865357
SGTC_2092 5303694 80.6725 µM -0.174702999312641 0.433118093360493 no 1922 0.430656505455894 2745 1963699
SGTC_295 k015-0027 31 µM -0.174918613075844 0.433037142945006 no 1923 0.430571792315531 2818 3887424
SGTC_1449 4112-4002 201 µM -0.176415819329495 0.432475106838889 no 1924 0.429983638771114 2743 2059539
SGTC_1628 st004252 77.7 µM -0.177140689646857 0.432203046849334 no 1925 0.429698940780541 2871 692968
SGTC_1475 4092-1048 11.7 µM -0.177280298482861 0.43215065222867 no 1926 0.42964411260742 2783 2881759
SGTC_2731 amoxapine 43.43 µM -0.177415597444065 0.432099876224832 no 1927 0.4295909783337 2713 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2533 agelasine 13.65 µM -0.181322304561535 0.430634225056705 no 1928 0.428057299845094 2873 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2688 kanamycin b 96.69 µM -0.182025768031174 0.430370412609715 no 1929 0.427781251871569 2846 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1947 st076332 61.6 µM -0.182082312324518 0.430349208750637 no 1930 0.427759064707781 2816 24208416
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.183390876503764 0.429858559218341 no 1931 0.427245666983861 2710 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_344 k064-0035 6.43 µM -0.184433275507562 0.429467786472512 no 1932 0.426836783732078 2745 5088750
SGTC_851 0394-0702 453 µM -0.185708676565458 0.428989760350309 no 1933 0.426336611885966 2757 762646
SGTC_3258 9138477 49.47 µM -0.186061934977185 0.428857375875459 no 1934 0.426198096055014 2757 4970355
SGTC_551 k048-0028 34.9 µM -0.186726266595732 0.428608437625695 no 1935 0.425937630267417 2896 6836383
SGTC_3051 9093778 49.47 µM -0.191313935552309 0.426890127422653 no 1936 0.424139821873121 2713 17217378
SGTC_985 1493-0307 8.71 µM -0.191502782513413 0.426819424331066 no 1937 0.424065850376157 2849 3278274
SGTC_739 1486-1183 203 µM -0.191699418583937 0.426745807545522 no 1938 0.42398883072209 2811 4346692
SGTC_1480 1070-0044 41.2 µM -0.19224335718436 0.426542180631861 no 1939 0.423775792558455 2837 3124987
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.192344525046383 0.426504309949724 no 1940 0.423736171762771 2746 688664
SGTC_2216 7189485 200 µM -0.193352053505602 0.426127193711612 no 1941 0.423341631286875 2849 731273
SGTC_962 1254-0300 21.5 µM -0.1936119995233 0.426029907294079 no 1942 0.423239850861347 2742 7340576
SGTC_2484 5809818 12.04 µM -0.194155239668405 0.425826610824548 no 1943 0.423027164732736 2802 2870548
SGTC_2126 5251174 33.877 µM -0.195334919551751 0.42538520780852 no 1944 0.422565380855542 2877 790722
SGTC_869 0564-0080 44.1 µM -0.199898526707476 0.423678519801955 no 1945 0.420779971353157 2793 6843321
SGTC_1558 st069300 45.6 µM -0.20158481892484 0.423048244154429 no 1946 0.42012065716433 2816 24208000
SGTC_936 3005-4620 401 µM -0.203769563789603 0.4222319577771 no 1947 0.419266789187339 2964 777207
SGTC_804 1595-0054 20.9 µM -0.203890996031833 0.422186596803748 no 1948 0.419219340706675 2786 761523 Stimulates phospholipase C.
SGTC_2109 5483026 200 µM -0.204261953141044 0.422048032295058 no 1949 0.419074400062965 2799 759335
SGTC_3166 9102297 49.47 µM -0.205712055338592 0.421506464839389 no 1950 0.418507920580976 2820 25237072
SGTC_510 ag-490 170 µM -0.20597385402452 0.421408707073052 no 1951 0.418405667427309 2831 5328779
SGTC_1162 k048-0130 20.1 µM -0.20632480456061 0.421277666878519 no 1952 0.418268602055349 2774 6797406
SGTC_3068 9116768 49.47 µM -0.206664809452082 0.421150721955312 no 1953 0.418135821020933 2869 41904888
SGTC_2398 5228213 48.84 µM -0.206963261542455 0.42103929802587 no 1954 0.418019275159106 2930 80771 YMR134W ERG29
SGTC_982 1491-0518 27.5 µM -0.207239418585428 0.42093620334947 no 1955 0.417911441949119 2792 3091256
SGTC_1698 5-fluorocytosine 1.055 µM -0.207572158437294 0.420811992436581 no 1956 0.417781522603336 2879 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1309 pyrazolanthrone 13.4 µM -0.207976817103373 0.420660945043084 no 1957 0.417623534418087 2868 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_348 k064-0012 10.7 µM -0.208408967920364 0.420499648521828 no 1958 0.417454827337553 2740 5066323
SGTC_886 0866-0150 153 µM -0.208938647517803 0.420301968443241 no 1959 0.417248066786148 2972 271463
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.209919823635887 0.419935839889753 no 1960 0.416865124955794 2788 77254
SGTC_1374 2889-5571 141 µM -0.210393535498173 0.419759097792086 no 1961 0.416680268835517 2840 2853281
SGTC_2608 thymoquinone 42.66 µM -0.210414374770061 0.419751323022247 no 1962 0.416672137169435 2754 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2192 5915882 198.485 µM -0.210843443876632 0.41959125176828 no 1963 0.416504718582613 2772 2876149
SGTC_1575 cyproterone acetate 48 µM -0.211588245358193 0.41931342298954 no 1964 0.41621414027735 2827 9880 An androgen receptor antagonist and liver toxin.
SGTC_1748 st037455 53.6035 µM -0.212951582997658 0.418804969715407 no 1965 0.415682363795848 2964 580690
SGTC_3061 glucosamine 200 µM -0.214029709117504 0.41840298131831 no 1966 0.415261944712404 2802 91431 and experimental redox chemotherapeutic
SGTC_2932 9016711 44.54 µM -0.215207292009454 0.417964006998702 no 1967 0.414802852962356 2891 7117328
SGTC_2974 9094440 9.66 µM -0.215964703564935 0.417681716318529 no 1968 0.414507630389856 2993 25236134
SGTC_3175 9106517 49.47 µM -0.216470318869946 0.417493294827254 no 1969 0.414310579392725 2886 41468073
SGTC_1705 st027868 56.3335 µM -0.217362043033987 0.417161033044898 no 1970 0.413963104652605 2865 292948
SGTC_136 0097-0015 404.482 µM -0.217946028558646 0.416943468567484 no 1971 0.413735581726002 2769 4861337
SGTC_3105 9121040 49.47 µM -0.21796798547103 0.416935288990275 no 1972 0.413727027795859 2715 41448907
SGTC_2684 capsaicin 100 µM -0.218247246343658 0.416831259474356 no 1973 0.413618237474764 2875 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1035 k081-0041 55.2 µM -0.220204750571611 0.416102219092987 no 1974 0.412855848505845 2805 731709
SGTC_1297 1068-0111 14.1 µM -0.220958704996315 0.415821497963282 no 1975 0.412562293446782 2781 767057
SGTC_1052 3253-3998 198 µM -0.22120345351835 0.415730379557971 no 1976 0.412467010172877 2754 5450317
SGTC_716 1683-5115 658 µM -0.222942528937246 0.415083062964981 no 1977 0.411790117976613 2766 723597
SGTC_142 0335-0849 62.6745 µM -0.223006861359886 0.415059121636309 no 1978 0.411765083189214 2820 3889043 YPR107C YTH1
SGTC_2635 hydroquinidine 100 µM -0.22449917184399 0.414503846584915 no 1979 0.411184455622125 2788 442912 An experimental heart treatment.
SGTC_1923 st058458 19.1 µM -0.225282306455553 0.414212517644114 no 1980 0.410879831655646 3047 3534982
SGTC_527 4476-4215 268 µM -0.226700419480341 0.413685094623336 no 1981 0.410328350455067 2822 4418754
SGTC_1471 k673-0312 37 µM -0.227458937797412 0.413403051176751 no 1982 0.410033447657756 2854 24099884
SGTC_1606 st000094 49.2 µM -0.228057873655976 0.413180377589476 no 1983 0.409800624538963 2893 1242210
SGTC_3236 9132701 49.47 µM -0.22824972489413 0.413109056649263 no 1984 0.409726053317783 2853 24282524
SGTC_1002 4049-0206 172 µM -0.228846061181063 0.412887386200824 no 1985 0.409494282476412 2806 4662749
SGTC_74 000s-0487 160.283 µM -0.229193463281933 0.412758262501826 no 1986 0.409359276460807 2775 677548
SGTC_3011 9081274 71.4286 µM -0.229312693889097 0.412713948603427 no 1987 0.409312944015771 2838 6625322
SGTC_2313 7726885 200 µM -0.229604723979242 0.412605415805918 no 1988 0.409199467868427 2923 726423
SGTC_3155 9099265 49.47 µM -0.229847087788636 0.412515346523329 no 1989 0.409105296667666 2912 25236499
SGTC_118 0083-0097 135.343 µM -0.231368365227149 0.411950101962351 no 1990 0.408514319670543 2845 5207356
SGTC_1674 st016616 23.6 µM -0.231612653245245 0.41185935150092 no 1991 0.408419439430263 2765 625830
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.236089255584721 0.410197179709666 no 1992 0.406681705552432 2958 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.236513869091486 0.410039603069512 no 1993 0.406516973273396 2769 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2025 5147754 141 µM -0.236737339158934 0.409956677808599 no 1994 0.406430282877363 2916 315777 YLR208W SEC13
SGTC_3164 9100705 49.47 µM -0.240069188806284 0.408720774790826 no 1995 0.405138309793995 2987 17174235
SGTC_2363 9053361 176 µM -0.240432042477144 0.408586233853319 no 1996 0.404997670146867 2996 6469797 YMR079W SEC14
SGTC_1854 st056233 32.9 µM -0.240749065271966 0.408468695164527 no 1997 0.404874804281507 2845 5393174
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.24082030460658 0.408442283754819 no 1998 0.404847195940081 2947 7104
SGTC_223 busulfan 5 mM -0.242339896699588 0.407879006455468 no 1999 0.404258400912931 2925 2478 A DNA alkylator.
SGTC_672 1441-0018 53.7 µM -0.242868023491651 0.407683286703135 no 2000 0.404053818783352 2824 251141
SGTC_1998 st075797 76.8 µM -0.24320705207806 0.407557657439117 no 2001 0.403922502043096 2848 24208315
SGTC_1863 st057641 20.1 µM -0.243676596061017 0.407383680542728 no 2002 0.403740650351783 2824 3921635
SGTC_76 0433-0009 400.328 µM -0.243718936836522 0.407367993204362 no 2003 0.403724253034393 2962 2841569
SGTC_2664 lyso-paf C-16 73.48 µM -0.244724802983968 0.40699536161301 no 2004 0.403334760945622 2847 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_284 0988-0104 32.6 µM -0.245041410640508 0.406878089039398 no 2005 0.403212183759095 2931 4666532
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.247590915418628 0.405934048812634 no 2006 0.402225470182917 3048 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_310 1273-0058 1.06 µM -0.247933033353163 0.405807409581239 no 2007 0.402093110381902 2951 2734232
SGTC_832 4083-0019 164 µM -0.248313450395371 0.405666605030395 no 2008 0.401945946468904 2973 1990758
SGTC_3003 9075612 71.4286 µM -0.248600853302528 0.405560236087081 no 2009 0.401834774188436 2910 6501993
SGTC_1079 idarubicin 2.36 µM -0.249030577053515 0.405401206652064 no 2010 0.401668564630037 2891 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_675 1309-0189 238 µM -0.249253121009398 0.40531885513491 no 2011 0.401582495546475 2889 4246530
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.249395023971219 0.405266346689227 no 2012 0.40152761693533 3016 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_600 1495-0418 41.6 µM -0.249863052990581 0.405093173696636 no 2013 0.401346628265625 2848 5377768
SGTC_1686 st019653 115.5 µM -0.250363150461899 0.404908155757832 no 2014 0.401153261988891 2978 97252
SGTC_123 0083-0120 66.675 µM -0.250377374199356 0.40490289380117 no 2015 0.401147762632566 2843 16001701
SGTC_2349 9023730 187.07 µM -0.25050439604829 0.404855903857751 no 2016 0.401098652751503 2996 4126287
SGTC_1136 pergolide 1.05886 µM -0.250903840486913 0.404708143959116 no 2017 0.400944227547697 2856 47811 A dopamine receptor agonist.
SGTC_1613 st002381 52.1 µM -0.25094728361723 0.404692074576695 no 2018 0.400927433367969 2857 551167
SGTC_2855 9016525 58.44 µM -0.251571095010159 0.404461347804975 no 2019 0.400686301505929 2809 43811474
SGTC_2080 5212524 12.4 µM -0.252365084409338 0.404167725995486 no 2020 0.400379442740866 2893 260183
SGTC_668 1682-0499 62.6 µM -0.253617507703171 0.403704682500381 no 2021 0.399895534793945 2904 682214
SGTC_2430 5571206 200 µM -0.25437252264745 0.403425604995554 no 2022 0.399603888351963 3019 1731771
SGTC_3211 9128781 49.47 µM -0.255586566026073 0.402976959158672 no 2023 0.399135046350262 2987 17194361
SGTC_1973 st070275 50.2 µM -0.256358892428016 0.402691614837259 no 2024 0.398836863262702 2828 17118334
SGTC_2529 gangaleoidin 93.61 µM -0.256627473938754 0.40259239663832 no 2025 0.398733181987335 2849 4565183
SGTC_3319 9138450 16.7555 µM -0.256796193534005 0.402530072196436 no 2026 0.398668054341901 2884 2029690
SGTC_2271 7849410 118.62 µM -0.257872351371076 0.402132601525315 no 2027 0.398252711885313 2851 972430
SGTC_2286 7945697 125 µM -0.258174350728388 0.402021078534647 no 2028 0.398136176107952 2923 1245733
SGTC_186 3455-3465 67.277 µM -0.258833242894773 0.401777789076097 no 2029 0.397881953769503 2844 755278
SGTC_124 0136-0217 7.121 µM -0.258866297461918 0.401765585003759 no 2030 0.397869201367953 3003 3976905
SGTC_3191 9110352 49.47 µM -0.26119539878472 0.40090589966583 no 2031 0.396970913117086 2848 17122424
SGTC_1975 st070967 30.8 µM -0.261403684199425 0.4008290435677 no 2032 0.396890608102664 3006 261391
SGTC_1274 0865-0114 173 µM -0.261732621807797 0.400707675335417 no 2033 0.396763794209208 2906 870624
SGTC_1026 k007-1105 30.6 µM -0.262543529473437 0.400408515392502 no 2034 0.396451215142361 2857 7066794
SGTC_145 3737-0113 38.366 µM -0.263768333375228 0.39995677171187 no 2035 0.395979218478962 3006 6849351
SGTC_1443 4112-3303 14 µM -0.263984409104933 0.399877090504093 no 2036 0.395895966238409 2883 704433
SGTC_3042 9091578 49.47 µM -0.265487371020191 0.399322965986594 no 2037 0.395317018689821 2884 25236497
SGTC_1067 clotrimazole 1.36 µM -0.265654462470367 0.399261373823563 no 2038 0.395252668571151 2886 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_569 4130-2812 160 µM -0.266313566852502 0.399018443523442 no 2039 0.3949988627176 2876 743552
SGTC_871 0574-0004 149 µM -0.266754760101557 0.398855851962141 no 2040 0.394828994284403 2873 9551173
SGTC_2601 securinine 100 µM -0.266816566268129 0.39883307613069 no 2041 0.394805199240639 2867 442872 A GABA receptor antagonist.
SGTC_2677 mitomycin C 100 µM -0.266835520222553 0.398826091588052 no 2042 0.394797902148113 2904 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1462 k081-0014 26.5 µM -0.266954224264359 0.398782349820234 no 2043 0.394752203058285 2894 3270634
SGTC_957 1187-1561 14.1 µM -0.267571070898891 0.398555065805019 no 2044 0.394514750649986 2840 1538454
SGTC_572 0960-0087 17.7 µM -0.268916560809072 0.398059424519361 no 2045 0.393996946285791 2905 6796365
SGTC_100 0086-0128 49.5915 µM -0.26964218246743 0.397792193769266 no 2046 0.39371777249228 2911 93297
SGTC_1594 piperine 70.1 µM -0.26966706624582 0.397783030461965 no 2047 0.393708199739801 2860 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1263 0774-1208 64.8 µM -0.271004501804172 0.397290610654219 no 2048 0.393193784922983 3043 906585
SGTC_2917 7979103 53.79 µM -0.273287237886914 0.396450526572936 no 2049 0.392316212384124 3038 2980565
SGTC_2060 5238662 140 µM -0.27379360926478 0.396264238633516 no 2050 0.392121617549921 2989 790130
SGTC_456 gingerol 170 µM -0.274348746203461 0.396060037645883 no 2051 0.391908313466492 3070 442793 A herb.
SGTC_2448 5185112 27.17 µM -0.274783958344003 0.395899969609002 no 2052 0.391741111625683 3025 5718189
SGTC_688 0527-0193 473 µM -0.274945664333628 0.395840499727536 no 2053 0.391678991753479 2913 4007154
SGTC_2920 7982904 15.77 µM -0.275599281837151 0.395600146489888 no 2054 0.39142793066084 2996 6456808
SGTC_351 caspofungin 25 nM -0.276411072342545 0.395301683945358 no 2055 0.391116176690189 2912 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_64 000l-0018 272.079 µM -0.277288388683818 0.394979199244527 no 2056 0.390779337314649 2851 6811119
SGTC_2921 7974240 10.71 µM -0.277321894930394 0.394966884414019 no 2057 0.390766474452164 3024 2979074 YDR527W RBA50
SGTC_463 ikarugamyin 104 µM -0.277349839893649 0.394956613648643 no 2058 0.390755746626955 2920 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_766 1391-0721 126 µM -0.278406623354764 0.39456826187045 no 2059 0.390350117861233 3062 1020919 YIL115C NUP159
SGTC_2667 digitoxin 100 µM -0.278448589789343 0.394552842006961 no 2060 0.390334012203491 2979 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_358 0075-0058 9.45 µM -0.280626001721176 0.393753015668398 no 2061 0.389498635305283 2844 1069125
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.281293812529188 0.393507799074375 no 2062 0.389242527844046 2881 91467 include heat shock
SGTC_2621 lithochol-11-enic acid 100 µM -0.281745002816483 0.393342148288222 no 2063 0.389069522230173 2978 6708711
SGTC_1361 1608-0041 5.61 µM -0.281924045089418 0.393276419745903 no 2064 0.389000875873777 2923 X1361
SGTC_439 amiodarone 34.4 µM -0.282530336407804 0.393053865611743 no 2065 0.388768444281942 2954 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3052 9092717 49.47 µM -0.283319756269132 0.392764142032699 no 2066 0.38846586707486 3075 25237534
SGTC_1521 st012942 49.4 µM -0.283581841060927 0.392667967886635 no 2067 0.388365427392606 3119 24207259
SGTC_755 1995-0008 37.3 µM -0.283702820531736 0.392623575696118 no 2068 0.388319066519625 2994 689533
SGTC_697 0508-1955 564 µM -0.28444575131846 0.392350995423462 no 2069 0.388034400898495 3069 6243113
SGTC_1508 1080-0625 72.9 µM -0.284569122147712 0.39230573594682 no 2070 0.387987135243715 2877 767111
SGTC_1603 st002045 67.8 µM -0.284727086111418 0.392247787856603 no 2071 0.38792661873958 3053 5887985
SGTC_61 0978-8327 98.565 µM -0.285732326461657 0.391879077769386 no 2072 0.387541571748417 3002 6150059 YHR072W ERG7
SGTC_98 0074-0023 107.663 µM -0.286916229305347 0.39144496094154 no 2073 0.387088231759444 2990 3563821
SGTC_2522 biochanin a 4.94 µM -0.287173060621776 0.391350803135318 no 2074 0.386989906233901 3039 5280373 A possible chelator.
SGTC_3262 9137218 49.47 µM -0.287355822990626 0.391283803875686 no 2075 0.386919941744861 2828 17650664
SGTC_3183 9108214 49.47 µM -0.287500334333792 0.391230829427409 no 2076 0.386864622988834 2994 4974831
SGTC_250 brefeldin a 552.239 µM -0.289692926737542 0.390427324873876 no 2077 0.386025584026563 2893 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2251 lansoprazole 556 µM -0.289957204711345 0.39033050822779 no 2078 0.385924488724164 2894 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_96 0929-0093 37.281 µM -0.290323609438741 0.390196289311637 no 2079 0.385784339286004 2914 6991579
SGTC_1350 1495-0454 146 µM -0.291330721562745 0.389827438239984 no 2080 0.38539919676927 3084 1069057
SGTC_1346 1488-2224 62.4 µM -0.292615658281216 0.389356978994682 no 2081 0.384907971911462 3015 3722427
SGTC_2778 tioconazole 65.09 nM -0.292895679380914 0.389254475192211 no 2082 0.384800945731253 2870 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1555 citronellol 128 µM -0.292983420341813 0.389222358547321 no 2083 0.384767412278711 3017 8842 A terpine precursor.
SGTC_1961 st076550 68.7 µM -0.293192757507855 0.389145735962798 no 2084 0.384687409822412 3034 1579337
SGTC_3188 9110789 49.47 µM -0.293452611429169 0.389050628992216 no 2085 0.384588108191239 3095 849217
SGTC_3278 9139605 49.47 µM -0.295195312003938 0.388412969708902 no 2086 0.383922341498824 3111 7958859
SGTC_481 bay k-8644 50 µM -0.29708603261499 0.387721489499283 no 2087 0.383200413800477 2930 2303 A calcium channel antagonist.
SGTC_2793 7325131 81.82 µM -0.298333105570385 0.387265600772045 no 2088 0.382724469723175 2999 4176441
SGTC_2400 5203494 178.7 µM -0.298414149495568 0.387235979159183 no 2089 0.382693545513875 2891 6777674
SGTC_2374 9071832 200 µM -0.298577179752756 0.387176393472164 no 2090 0.38263133976349 2896 17381698
SGTC_477 mead ethanolamide 10 µM -0.299102922092 0.386984258799491 no 2091 0.382430758391116 2896 16061185
SGTC_2416 tofa 880 nM -0.299474886401983 0.386848339654731 no 2092 0.382288865505514 2946 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_504 lovastatin 124 µM -0.299580252342261 0.386809840502383 no 2093 0.382248674528398 2964 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2575 plumbagin 510 nM -0.30131991239728 0.386174355782721 no 2094 0.381585279104509 2891 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1212 0520-0165 585 µM -0.303257438701631 0.385466951357048 no 2095 0.380846839408997 3342 5403258
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.303466648497848 0.385390590135769 no 2096 0.380767130229202 3088 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_582 0987-0078 156 µM -0.304064992535972 0.385172220108827 no 2097 0.380539188386737 3048 1625765
SGTC_1967 st070177 51.4 µM -0.304330917845425 0.385075180406721 no 2098 0.380437896254127 3096 5729214
SGTC_949 1165-0505 146 µM -0.305469630146225 0.384659730518864 no 2099 0.380004248459505 2945 6244267
SGTC_1134 3477-0009 42.5 µM -0.307247302183412 0.384011426260287 no 2100 0.379327571810406 3199 3973534
SGTC_1452 4194-0072 190 µM -0.307915132874213 0.383767956927593 no 2101 0.379073455257417 3103 1343545
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.307920029108953 0.383766172089063 no 2102 0.379071592381775 2979 65057 A dermal irritant. YDR527W RBA50
SGTC_681 1642-0006 26.6 µM -0.308099203419934 0.383700858858736 no 2103 0.379003423673263 3037 4446530
SGTC_2182 6325192 200 µM -0.308589974350743 0.383521978290683 no 2104 0.378816724103172 2963 736248
SGTC_3074 9116018 49.47 µM -0.30872277610599 0.383473577787852 no 2105 0.378766208384872 2918 17027303
SGTC_2247 cerulenin 830 nM -0.309272052965303 0.383273409422826 no 2106 0.378557294033443 3172 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_25 0118-0223 35.662 µM -0.311673814624395 0.382398522173819 no 2107 0.377644215129121 3096 5333628
SGTC_690 glyoxal 20.3 µM -0.311684877454611 0.382394493712791 no 2108 0.377640010944703 2985 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3201 9113999 49.47 µM -0.311798182417216 0.382353235146032 no 2109 0.377596952729448 3135 16649224
SGTC_1416 3966-0321 25.3 µM -0.312495718492916 0.382099265657562 no 2110 0.377331908206513 3010 582530 YLR208W SEC13
SGTC_914 3820-6779 408 µM -0.31592851551382 0.380850141948549 no 2111 0.376028383662025 2915 2893481
SGTC_3195 9113082 49.47 µM -0.316502357372122 0.380641453483987 no 2112 0.375810618073231 3055 17018038
SGTC_905 2-aminofluorene 215 µM -0.318407830533274 0.379948741471716 no 2113 0.375087799613422 2976 1539 An established DNA mutagen. YPR165W RHO1
SGTC_3208 9114115 49.47 µM -0.319471288568123 0.379562301247178 no 2114 0.374684579992921 3029 650895
SGTC_1518 st038567 90.8 µM -0.320898011109459 0.379044046650885 no 2115 0.374143840599911 3005 77966
SGTC_1667 st014849 34.6 µM -0.32139771990933 0.378862579605613 no 2116 0.373954505395927 2952 5348460
SGTC_1406 3909-7906 11.9 µM -0.321997912180316 0.378644657726565 no 2117 0.373727138097078 3008 X1406
SGTC_1330 1469-0054 61.8 µM -0.322286924719328 0.378539734852346 no 2118 0.373617668849086 3113 7102664
SGTC_3101 9120531 49.47 µM -0.327616538890001 0.376606488488593 no 2119 0.371600807649049 3193 24824904
SGTC_2202 7226349 200 µM -0.328213167927915 0.376390260747152 no 2120 0.37137524613276 2966 844334
SGTC_3174 9107204 49.47 µM -0.328391159196394 0.376325761421933 no 2121 0.371307963321053 3110 3938802
SGTC_961 1252-1571 372 µM -0.328423067337054 0.376314199121186 no 2122 0.371295902080862 3167 6813498
SGTC_1441 4106-0040 13 µM -0.329135130458346 0.37605620332965 no 2123 0.371026775949105 2997 2904180
SGTC_3089 9117425 49.47 µM -0.329397607318589 0.375961116279349 no 2124 0.370927588030354 3038 9401657
SGTC_210 3551-0445 56.827 µM -0.329662985694413 0.375864985757816 no 2125 0.370827312370014 3112 2865180 YOR207C RET1
SGTC_1942 st076330 65.2 µM -0.330113002450651 0.375701989538405 no 2126 0.370657289453139 3133 24208414
SGTC_1163 k060-0048 49.9 µM -0.330403268798704 0.37559686673519 no 2127 0.37054763597567 2985 6809982
SGTC_2091 4-phenylthiadiazole 200 µM -0.330988286026472 0.375385025081147 no 2128 0.370326666869321 2984 270010
SGTC_2334 9017922 200 µM -0.331834689266764 0.375078598979396 no 2129 0.370007044391485 3117 3163164
SGTC_2138 5575593 77.673 µM -0.332672173298053 0.374775479510709 no 2130 0.369690878368156 3000 762213
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.332769974324709 0.374740086389242 no 2131 0.369653962374689 2933 6708630 An antioxidant.
SGTC_3128 9127691 49.47 µM -0.332800176510882 0.37472915676173 no 2132 0.369642562494733 3105 41316314
SGTC_765 1319-0117 244 µM -0.332994405709121 0.374658871115915 no 2133 0.36956925300549 2995 3487746 YGL099W LSG1
SGTC_1805 st050013 60.3 µM -0.333281852568164 0.374554860472354 no 2134 0.369460768325774 3034 4037144
SGTC_1103 duloxetine 36.1 µM -0.334793704831944 0.374007957665327 no 2135 0.368890354785966 3143 60835 A selective serotonin reuptake inhibitor.
SGTC_2235 salicylic acid 500 µM -0.335060677599312 0.373911408293627 no 2136 0.368789657382879 3036 338 A COX inhibitor and kinase inhibitor.
SGTC_778 3456-2434 196 µM -0.335807447084413 0.373641384855785 no 2137 0.368508037003662 3123 5539063
SGTC_1125 tnp00248 1.32998 µM -0.337192900745627 0.373140584758855 no 2138 0.36798574431836 3159 24207736
SGTC_1324 1418-0026 34.4 µM -0.340689479952607 0.37187763027954 no 2139 0.366668679587531 3108 1372513
SGTC_922 1866-0035 480 µM -0.340936540656283 0.371788444599762 no 2140 0.366575677793758 2984 3156169
SGTC_1393 3470-5649 58.2 µM -0.341250921834239 0.371674967058152 no 2141 0.366457345680694 3070 4108395
SGTC_468 gf-109203x 121 µM -0.341513373130704 0.371580242419332 no 2142 0.366358569537841 3055 2396 A protein kinase C inhibitor.
SGTC_3126 9127922 49.47 µM -0.34164179952833 0.371533893246121 no 2143 0.366310238217655 3218 45595682
SGTC_1648 st011736 69.8 µM -0.342330707434829 0.371285297726643 no 2144 0.366051014425737 3152 2855514
SGTC_2492 derrusnin 100 µM -0.342976211694064 0.371052413327847 no 2145 0.365808178123398 2942 1715307 Part of coumarin class of compounds.
SGTC_3321 9137793 26.8275 µM -0.343519820014574 0.370856327467188 no 2146 0.365603716388163 3063 4904192
SGTC_2332 7982454 138.89 µM -0.343541918766445 0.370848356898646 no 2147 0.365595405421992 3093 2981748
SGTC_2701 st077767 14.721 µM -0.344759608868911 0.370409246690997 no 2148 0.365137550429988 3045 5721188
SGTC_592 k241-0073 46.5 µM -0.345259606305832 0.370228991887576 no 2149 0.364949605571253 3152 4230158
SGTC_2146 5545642 200 µM -0.345541148419498 0.370127505268354 no 2150 0.364843790517487 3079 825326
SGTC_1198 1612-1005 86.7 µM -0.348658544838524 0.36900439274383 no 2151 0.363672834960025 3198 6998509
SGTC_3288 9119690 36.221 µM -0.349426841224496 0.368727767884016 no 2152 0.363384442684155 3054 17595618 YKL019W RAM2
SGTC_3010 9080089 71.4286 µM -0.350323210086084 0.368405116527791 no 2153 0.363048074221298 3116 17027233
SGTC_2840 9008771 71.43 µM -0.350702176640919 0.36826873397462 no 2154 0.362905896214319 3117 2992978
SGTC_2850 9015429 58.44 µM -0.35586122207967 0.366413753325558 no 2155 0.36097224877064 3091 6457570
SGTC_1754 st042065 16.137 µM -0.356770690532923 0.366087067775759 no 2156 0.360631739886096 3096 1126236 YIL048W NEO1
SGTC_1724 st037281 8.293 µM -0.357019527684361 0.365997701144401 no 2157 0.360538593427567 3000 574124 YDL195W SEC31
SGTC_1133 3473-0247 50 µM -0.35810972179325 0.365606257838068 no 2158 0.360130601971126 3067 711311
SGTC_2289 7946404 165.07 µM -0.362731307454489 0.363948397046626 no 2159 0.35840280515244 3008 1246120 YPR165W RHO1
SGTC_323 4013-0906 34.3 µM -0.367182188145507 0.362354174955003 no 2160 0.356741562310635 3134 2910086
SGTC_121 0557-0495 61.343 µM -0.367259627924983 0.36232645849983 no 2161 0.356712682681735 3071 3104427
SGTC_525 k781-2675 26.7 µM -0.367790906540168 0.36213632814869 no 2162 0.356514575020157 3128 3651118 YDL195W SEC31
SGTC_384 k007-0144 5.16 µM -0.36812195802296 0.362017870908244 no 2163 0.356391149315264 3099 6824886
SGTC_792 4534-1957 155 µM -0.369755068916929 0.361433702803802 no 2164 0.355782497996702 3064 1717904
SGTC_141 0443-0274 32.331 µM -0.371264608980989 0.360894023422096 no 2165 0.355220227578932 3212 1627241
SGTC_2373 9071805 200 µM -0.375757604019035 0.359289363684744 no 2166 0.3535485544552 3223 10149009
SGTC_3115 9123671 49.47 µM -0.375917515426262 0.359232297320925 no 2167 0.353489109278531 3180 3286988
SGTC_488 nitrendipine 139 µM -0.376877015683941 0.358889953775043 no 2168 0.353132501482569 3082 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3091 9116372 49.47 µM -0.377011186187871 0.358842091622824 no 2169 0.353082645951373 3223 17169793
SGTC_1450 4112-4260 37.6 µM -0.377186584461827 0.358779525781745 no 2170 0.353017474668817 3210 1633175
SGTC_1270 0831-1170 17.3 µM -0.377586024419539 0.358637056783444 no 2171 0.352869074167328 3091 6764716
SGTC_3143 9086658 49.47 µM -0.37777228718714 0.358570628816255 no 2172 0.352799881209014 3111 25236626
SGTC_3066 9117245 49.47 µM -0.378227151920496 0.358408425764224 no 2173 0.352630928364264 3096 17176980
SGTC_579 4491-1009 110 µM -0.378709154299923 0.358236573404861 no 2174 0.352451927356167 3208 1271041
SGTC_1768 st044301 37.178 µM -0.379594717114562 0.357920911113414 no 2175 0.352123141470564 3114 3931349
SGTC_2099 5377090 177.372 µM -0.380153100833851 0.357721922989017 no 2176 0.351915885260572 3161 2243829
SGTC_839 0122-0028 230 µM -0.381417268391628 0.357271561496248 no 2177 0.351446824713238 3080 759448
SGTC_753 1322-0200 289 µM -0.381704351243182 0.357169315490896 no 2178 0.351340336107235 3201 5403907
SGTC_3283 9109332 35.8195 µM -0.381756012126392 0.357150917295411 no 2179 0.351321174600961 3088 17027281
SGTC_2863 9028737 58.44 µM -0.381791327610714 0.357138340442868 no 2180 0.351308075973951 3135 6460917
SGTC_799 1310-0557 151 µM -0.383325993525256 0.356591952186973 no 2181 0.350739034221706 3230 5354492
SGTC_826 1683-5028 118 µM -0.383926260463659 0.356378318668056 no 2182 0.350516551063574 3151 722377
SGTC_2424 5537928 59.2 µM -0.384473884208643 0.356183460036533 no 2183 0.350313624316363 3085 5382802
SGTC_1641 st009299 47.1 µM -0.38793825953116 0.354951618132397 no 2184 0.349030862002189 3171 4046054
SGTC_860 0443-0016 25.1 µM -0.389235186175887 0.354490853657416 no 2185 0.348551088456976 3101 5337942
SGTC_1488 4013-0813 75.9 µM -0.390513083309216 0.354037058056447 no 2186 0.348078591347233 3099 2910057
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.391034118910644 0.353852091910186 no 2187 0.347886008232413 3091 641818 YHR062C RPP1
SGTC_1992 st073643 23.3 µM -0.391262132968257 0.353771158419476 no 2188 0.347801742918519 3074 3161292
SGTC_1873 rapamycin 2 nM -0.392535331155749 0.353319358839532 no 2189 0.347331355630076 3104 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2521 angolensin 13.4 µM -0.392620782597383 0.3532890434388 no 2190 0.34729979372109 3235 821428 A flavenoid.
SGTC_1481 3346-2004 36 µM -0.393778105235134 0.352878554643126 no 2191 0.346872435296165 3189 2770522
SGTC_1164 k060-0068 93.7 µM -0.393938994122407 0.35282150278058 no 2192 0.346813040110547 3096 5963676
SGTC_2487 5918373 44.05 µM -0.3941630351154 0.352742062434141 no 2193 0.34673033739782 3257 2876279
SGTC_231 b-estradiol 524 µM -0.394570844982064 0.352597477891617 no 2194 0.346579816809854 3086 450 A steroid.
SGTC_1723 st034307 2.5525 µM -0.39597129390694 0.35210112620964 no 2195 0.346063102611668 3160 867466
SGTC_3139 9095020 49.47 µM -0.396121654733277 0.352047849792513 no 2196 0.346007642005192 3022 25236292
SGTC_923 1900-2434 73.3 µM -0.397351316895563 0.351612260314312 no 2197 0.345554205050735 3053 5910570
SGTC_1742 st038235 28.8875 µM -0.397612378595372 0.351519808145051 no 2198 0.345457967239187 3197 564103 YBR002C RER2
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.397972058029905 0.351392445961312 no 2199 0.345325391339015 3224 1377
SGTC_2380 9035439 200 µM -0.399410007970374 0.350883435909008 no 2200 0.344795560464888 3254 6462575
SGTC_2470 5664817 21.68 µM -0.402191145558633 0.349899719721225 no 2201 0.3437716790711 3158 2859561
SGTC_1766 st045414 44.774 µM -0.402316715960427 0.349855327916752 no 2202 0.343725477032364 3123 253960
SGTC_1765 st044815 90.4 µM -0.402694409536099 0.349721817586884 no 2203 0.343586523536046 3195 645695
SGTC_1218 1348-1416 30.7 µM -0.405545822030863 0.348714476832746 no 2204 0.342538171823615 3103 6787668
SGTC_1746 st038117 42 µM -0.406833293497338 0.348259990494863 no 2205 0.342065216041114 3193 2898218
SGTC_947 3447-0010 211 µM -0.406868756221333 0.34824747498732 no 2206 0.342052192224806 3185 748350
SGTC_1779 st039427 55 µM -0.407141872403885 0.348151092339189 no 2207 0.341951895596027 3327 1124498
SGTC_2891 9063876 19.48 µM -0.407257063981205 0.348110444193912 no 2208 0.341909597063436 3205 6472478
SGTC_209 4077-0173 175.592 µM -0.407642112057811 0.347974583297516 no 2209 0.341768221194739 3194 15993494
SGTC_441 propafenone 146 µM -0.409146230074039 0.347444055349344 no 2210 0.34121617570135 3088 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1249 0481-0015 10.2 µM -0.409972427895919 0.347152768389482 no 2211 0.340913086771655 3075 4227577
SGTC_3187 9109394 49.47 µM -0.410023770345831 0.34713466990791 no 2212 0.340894255287847 3156 17098090
SGTC_667 1498-1044 59 µM -0.411144013303209 0.346739865275177 no 2213 0.340483469153696 3154 6739982
SGTC_2036 5160441 105 µM -0.411408584598144 0.346646647296485 no 2214 0.34038648009954 3167 134534 YIL048W NEO1
SGTC_1012 4112-3522 18 µM -0.412030068247561 0.346427712792284 no 2215 0.340158692263078 3272 3112398
SGTC_2506 ethyl hematommate 54.16 µM -0.414895815581283 0.345418840022356 no 2216 0.339109086587511 3196 3940691 An allergen.
SGTC_18 0111-0177 500 nM -0.415116839346277 0.345341075139216 no 2217 0.339028186365458 3171 721752
SGTC_2106 5357045 167.29 µM -0.415354918390464 0.34525731683942 no 2218 0.338941051788572 3210 668842
SGTC_1 0258-0098 57.368 µM -0.415529582049056 0.345195873448729 no 2219 0.338877132094981 3174 6790032 YDR047W HEM12
SGTC_2021 4019055 173 µM -0.416235269723203 0.344947667356076 no 2220 0.338618926769072 3288 44827708 YER133W GLC7
SGTC_2399 5884133 200 µM -0.417868449154377 0.344373497699855 no 2221 0.338021650831594 3140 722445
SGTC_1431 4049-0260 9.09 µM -0.419336503776312 0.343857686109139 no 2222 0.337485111005241 3155 3854841
SGTC_2194 5927483 104.545 µM -0.41953374424618 0.343788406361567 no 2223 0.337413049341207 3130 760979
SGTC_3331 9141060 1.957 µM -0.420991612157495 0.343276500209083 no 2224 0.336880603414045 3118 4906567 YPR165W RHO1
SGTC_1829 berberine 14.4 µM -0.421643070474527 0.343047844273912 no 2225 0.336642781837122 3285 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1253 0550-0034 176 µM -0.42262358877257 0.342703799632689 no 2226 0.336284956684249 3241 5969915
SGTC_1307 1187-1599 12.2 µM -0.422819252039422 0.342635160831064 no 2227 0.336213570102477 3116 1538471
SGTC_1946 st076057 65.1 µM -0.423055206365715 0.34255239481003 no 2228 0.336127491421885 3171 953009
SGTC_852 0418-0143 439 µM -0.423652426073143 0.342342941025006 no 2229 0.335909657642389 3255 5369229
SGTC_1850 st056238 17 µM -0.423673676748295 0.342335488991824 no 2230 0.335901907548617 3193 5393177
SGTC_184 1494-0393 24.714 µM -0.423842288779273 0.342276363519434 no 2231 0.335840417432215 3097 3090647
SGTC_3297 9117502 71.43 µM -0.430391045060224 0.339982980873314 no 2232 0.333455604149458 3254 7453720
SGTC_1349 flufenamic acid 69 µM -0.431672531827309 0.339534891231833 no 2233 0.332989717003195 3142 3371 A non-steroidal anti-inflammatory.
SGTC_20 0481-0013 4.944 µM -0.432846032902736 0.339124759141047 no 2234 0.332563314259129 3221 182045
SGTC_448 monastrol 171 µM -0.434657708647249 0.338491962866948 no 2235 0.331905450054086 3210 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1064 honokiol 6.76 µM -0.434858706854172 0.338421784696925 no 2236 0.331832494522216 3236 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1936 st074407 74.3 µM -0.436821844353457 0.33773665407628 no 2237 0.331120277834987 3156 809813
SGTC_2512 diallyl trisulfide 49.23 µM -0.43732332754472 0.337561723633739 no 2238 0.330938439990506 3252 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1830 st055982 50.3 µM -0.437626717994222 0.337455910151961 no 2239 0.330828449946342 3282 455313 An antimicrobial agent.
SGTC_23 0213-0011 39.996 µM -0.437634224522943 0.337453292262963 no 2240 0.330825728742449 3332 627608
SGTC_1878 temozolomide 1 mM -0.438279393491055 0.33722832010249 no 2241 0.33059188090932 3276 5394 DNA alkylating agent.
SGTC_2616 abietic acid 100 µM -0.438420548017955 0.337179106893665 no 2242 0.330540726875931 3328 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_557 1315-0110 16.2 µM -0.438759412524143 0.33706097391854 no 2243 0.330417936183506 3142 6833801
SGTC_300 r073-0011 5.04 µM -0.441547797069044 0.336089514480534 no 2244 0.32940823339407 3276 2735780
SGTC_2958 9077254 16.72 µM -0.443011891857346 0.335579868549787 no 2245 0.328878566608118 3370 16457351
SGTC_3277 9138724 49.47 µM -0.443490122555833 0.335413463688412 no 2246 0.328705631058362 3191 15943418
SGTC_3015 9080845 49.47 µM -0.443492808183369 0.335412529290225 no 2247 0.328704659997812 3313 5296973
SGTC_2166 5933061 31.504 µM -0.444324042255608 0.335123370743305 no 2248 0.328404160666338 3590 2877375
SGTC_1003 4049-0218 100 µM -0.44633650133382 0.334423708311083 no 2249 0.327677096684783 3326 295161
SGTC_1412 3909-8563 178 µM -0.446417441219349 0.334395580318559 no 2250 0.327647868251107 3305 23767530
SGTC_1822 st052468 42 µM -0.447363504944957 0.334066875994673 no 2251 0.327306310826306 3242 2873678
SGTC_2294 7971431 200 µM -0.447826994949388 0.333905885518579 no 2252 0.327139029744003 3277 5741572
SGTC_3271 9137798 49.47 µM -0.447948301699114 0.333863755391332 no 2253 0.327095253895869 3266 6498326
SGTC_2302 7771753 200 µM -0.450178586374391 0.333089545792067 no 2254 0.326290837672219 3246 2203047
SGTC_2782 7736369 71.43 µM -0.450338060658109 0.333034213898701 no 2255 0.326233349578211 3202 2950836 YOL077C BRX1
SGTC_134 0269-0018 6.916 µM -0.450789946020326 0.332877445527335 no 2256 0.326070474091496 3233 4378915
SGTC_2834 9001755 58.44 µM -0.45173856424874 0.332548445303923 no 2257 0.325728666441361 3175 2989575
SGTC_159 3970-0959 50 µM -0.452930981859044 0.33213507339159 no 2258 0.325299220368025 3359 6615653
SGTC_1137 ixabepilone 100 µM -0.454556377487873 0.331571931168636 no 2259 0.324714211945279 3263 154225 A novel microtubule stabilizer.
SGTC_1708 st033234 31.827 µM -0.455557078394734 0.331225412768766 no 2260 0.324354256931755 3335 674664
SGTC_689 0833-0039 98 µM -0.456173226262714 0.331012127580205 no 2261 0.324132708345635 3260 5374726
SGTC_89 0302-0250 142.109 µM -0.459511175954163 0.329857620517485 no 2262 0.322933564172898 3305 4203518 YLR208W SEC13
SGTC_2301 7769476 200 µM -0.460840803953226 0.329398188185181 no 2263 0.322456412258023 3248 977820
SGTC_1432 4049-0298 68.4 µM -0.462176649952906 0.328936866544967 no 2264 0.321977323282172 3301 741646
SGTC_486 niguldipine 82 µM -0.462212952150128 0.32892433356047 no 2265 0.321964307954447 3218 1236 A calcium channel blocker.
SGTC_2028 5153890 36.43 µM -0.463670204474443 0.328421390170644 no 2266 0.321442023737439 3248 2830968 YPR165W RHO1
SGTC_2845 9003024 42.97 µM -0.464532433363661 0.328123954257411 no 2267 0.321133164017348 3405 2990173
SGTC_1827 berberine 7.24 µM -0.46477486518979 0.328040344185808 no 2268 0.321046344582579 3188 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1872 amphotericin b 148 nM -0.464905244434084 0.327995382456022 no 2269 0.320999657347186 3297 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2037 5169046 200 µM -0.465975529715897 0.327626385169387 no 2270 0.320616508111391 3306 5718022
SGTC_422 cantharidin 155 µM -0.470984263933124 0.325901788582685 no 2271 0.318825986149867 3183 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.47340166877932 0.325070760853272 no 2272 0.317963319760945 3299 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_413 propylparaben 100 µM -0.474816167636973 0.324584903574344 no 2273 0.31745900411577 3226 7175 A pharmaceutical preservative.
SGTC_2172 5754775 163.918 µM -0.475120783310872 0.324480312078354 no 2274 0.317350442832759 3210 2263357
SGTC_1108 betulinic acid 729.144 nM -0.475815795961492 0.324241727430745 no 2275 0.317102807693124 3271 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_475 α-linolenic acid 10 µM -0.475909718382802 0.324209491178446 no 2276 0.31706934912433 3458 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2553 4-methylesculetin 85.09 µM -0.476317553965369 0.324069528273183 no 2277 0.31692408066512 3286 5319502
SGTC_375 3970-0961 9.27 µM -0.477794805074778 0.323562766648223 no 2278 0.316398129493624 3256 2898222
SGTC_2946 9065502 71.43 µM -0.478417772024796 0.323349159767822 no 2279 0.316176443461665 3239 16489101
SGTC_47 0149-0135 24.25 µM -0.478528848706632 0.323311079200273 no 2280 0.316136923183866 3229 5239155
SGTC_2212 7123476 200 µM -0.47888932721588 0.323187508623357 no 2281 0.316008682016865 3271 1085715
SGTC_3034 9090421 49.47 µM -0.481591477755627 0.322261844288511 no 2282 0.31504809070779 3300 17173761
SGTC_1635 st007035 42.4 µM -0.482928006065111 0.321804402055544 no 2283 0.314573427793729 3331 3716403
SGTC_320 4092-0846 5.34 µM -0.483347056259192 0.321661032848433 no 2284 0.314424666757938 3307 1359356
SGTC_492 tmb-8 126 µM -0.483570941742054 0.32158444602291 no 2285 0.314345200711052 3267 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2811 7967822 32.47 µM -0.483906575519693 0.321469646505354 no 2286 0.314226086774158 3355 2232244
SGTC_3299 9121982 43.1275 µM -0.484055067092708 0.321418862179195 no 2287 0.314173394388646 3264 17594604 YPL160W CDC60
SGTC_2972 9093619 59.92 µM -0.485463023972862 0.32093750493873 no 2288 0.313673967784397 3202 25236256
SGTC_497 capsazepine 133 µM -0.485935975602909 0.32077587802911 no 2289 0.313506280208829 3268 2733484 A calcium channel blocker.
SGTC_660 4031-1742 102 µM -0.486884844559237 0.320451713164921 no 2290 0.313169969790461 3290 6738706
SGTC_3032 9089427 49.47 µM -0.487960023816484 0.320084562031193 no 2291 0.312789078581722 3323 17173707
SGTC_798 1287-0182 476 µM -0.488566899303831 0.319877404532473 no 2292 0.312574176069612 3393 1649755
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.48945041596243 0.319575915728684 no 2293 0.312261425223342 3281 4620898
SGTC_71 0417-1750 47.813 µM -0.489515121690267 0.319553840405852 no 2294 0.312238525736471 3384 6811472
SGTC_587 k089-0003 57 µM -0.489695001774762 0.319492474995389 no 2295 0.312174869624876 3341 9659696
SGTC_385 1494-0393 12.4 µM -0.493121178373602 0.318324593093323 no 2296 0.31096348371342 3279 3090647
SGTC_1335 1486-0900 202 µM -0.493433855979369 0.318218100208442 no 2297 0.310853032628182 3336 X1335
SGTC_3285 9112818 20.8695 µM -0.494276013317113 0.317931349919175 no 2298 0.310555631462104 3318 17017947 YPR165W RHO1
SGTC_1796 st049173 110.4 µM -0.494339691270412 0.317909672335831 no 2299 0.310533149130451 3362 94134
SGTC_1255 0566-0045 221 µM -0.496066406704426 0.31732209286509 no 2300 0.309923779742014 3400 2788469
SGTC_80 0159-0065 512.242 µM -0.496169111922086 0.317287158058855 no 2301 0.309887550811997 3338 1548079
SGTC_1155 4088-0394 48.2 µM -0.497255084087725 0.316917868231036 no 2302 0.309504590696901 3251 2326248
SGTC_1005 4092-0690 4.4 µM -0.500832279256686 0.315702717507494 no 2303 0.308244583050808 3280 1529343
SGTC_1303 1160-0052 261 µM -0.502200832385608 0.315238354045644 no 2304 0.307763128743118 3354 3562476
SGTC_188 3229-0966 278.469 µM -0.502494946951017 0.315138596160723 no 2305 0.307659702975668 3404 5722370
SGTC_2317 5986382 200 µM -0.503585045960884 0.314768973599236 no 2306 0.307276501607436 3353 877883
SGTC_760 0568-0725 82.9 µM -0.503852748268746 0.314678231473319 no 2307 0.307182428645455 3401 3916171
SGTC_712 r015-0009 80.6 µM -0.504517733196314 0.314452872265407 no 2308 0.306948801967115 3381 6813872 YLR060W FRS1
SGTC_2944 9067346 25.62 µM -0.505258100153771 0.314202047883153 no 2309 0.306688783801242 3384 6473075
SGTC_865 0488-0499 301 µM -0.505611209385784 0.314082450376159 no 2310 0.3065648054683 3425 9634651
SGTC_2760 etidronate 98.04 µM -0.50639333369242 0.313817615703002 no 2311 0.306290276719703 3276 3305 A chelator and antioxidant.
SGTC_1311 1190-0148 100 µM -0.506651596462591 0.313730186544795 no 2312 0.306199649326865 3412 1961333
SGTC_952 1185-0122 232 µM -0.507333250325156 0.313499477926788 no 2313 0.305960506066087 3329 678600
SGTC_21 0849-0113 22.993 µM -0.508054746236598 0.313255364059056 no 2314 0.305707475179107 3314 1560156
SGTC_1331 1472-0049 76.2 µM -0.508935961794776 0.312957320973824 no 2315 0.305398555918345 3262 24051409
SGTC_201 4262-0159 12.803 µM -0.510027424486252 0.312588337909225 no 2316 0.305016124389893 3304 1341029
SGTC_472 calcifediol 10 µM -0.510786915867619 0.312331692797797 no 2317 0.304750135993955 3357 5283731 A vitamin D metabolite.
SGTC_3060 1327-0027 12.5 µM -0.51159728615446 0.312057955202453 no 2318 0.304466442601206 3309 16000455 YPR107C YTH1
SGTC_166 k072-0058 166.424 µM -0.511853021798678 0.311971590962948 no 2319 0.304376939397581 3423 5846229
SGTC_2134 5324836 1.464 µM -0.513015270647278 0.311579219300153 no 2320 0.303970319385499 3267 699272
SGTC_265 mycophenolic acid 32.932 µM -0.513344729431129 0.311468033904957 no 2321 0.303855100247098 3506 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1407 3909-7909 12.3 µM -0.513528244992974 0.311406108725443 no 2322 0.3037909291812 3374 4411780
SGTC_1985 st071382 65.5 µM -0.514058124636131 0.311227336987218 no 2323 0.303605676704761 3389 6123237
SGTC_791 1348-1292 225 µM -0.515484763525251 0.310746236388582 no 2324 0.303107157001301 3386 5437054
SGTC_1849 st056239 19.2 µM -0.516508517977694 0.310401198388773 no 2325 0.30274964563609 3272 5393181
SGTC_2065 5221596 34.26 µM -0.518157172222372 0.309845899803645 no 2326 0.302174306670569 3393 788581
SGTC_741 4582-0002 126 µM -0.518857006878078 0.309610312991368 no 2327 0.301930230402153 3306 2912688
SGTC_817 1391-0715 46 µM -0.519691004529404 0.309329664735124 no 2328 0.301639478804789 3319 1353946
SGTC_2780 5215298 71.43 µM -0.520849517049988 0.308939998623105 no 2329 0.301235802631503 3430 2834131
SGTC_3295 9122362 53.5725 µM -0.521880042984643 0.308593561441027 no 2330 0.300876927184242 3383 4730473
SGTC_2918 7977171 22.06 µM -0.52384082476664 0.307934865869543 no 2331 0.300194627913633 3356 2236483
SGTC_3237 9133362 49.47 µM -0.524481766939314 0.307719684842523 no 2332 0.299971749105831 3389 43845137
SGTC_2511 berberine 10.47 µM -0.524792147288016 0.307615505812155 no 2333 0.299863845534288 3325 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_230 MPP+ 141.667 µM -0.525202814804346 0.307477689279027 no 2334 0.299721104190381 3378 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2409 alverine citrate 63.97 µM -0.525316713058137 0.307439470804253 no 2335 0.299681520463524 3480 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1916 st067606 49.2 µM -0.526787553259378 0.306946119390259 no 2336 0.29917056365655 3356 19590279
SGTC_1900 st060200 72.8 µM -0.528433606619077 0.306394411996135 no 2337 0.298599208662807 3314 688945
SGTC_168 3970-0862 530.542 µM -0.528548376830281 0.306355960829045 no 2338 0.29855938974711 3387 3135186
SGTC_1315 1237-0019 3.69 µM -0.529186738592218 0.306142131062028 no 2339 0.298337957611863 3419 825140
SGTC_1962 st076595 64.5 µM -0.529850214228201 0.305919958964875 no 2340 0.298107893348041 3351 279619
SGTC_2734 clemastine 41.6 µM -0.529977698624973 0.305877277590207 no 2341 0.298063696607429 3344 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2339 9000433 200 µM -0.530574921906571 0.305677364225749 no 2342 0.297856688900732 3315 2988954
SGTC_3306 9127676 59.7925 µM -0.530781195231095 0.305608330143367 no 2343 0.297785206307267 3377 41905287
SGTC_2804 7954240 19.48 µM -0.53111512841286 0.305496586419743 no 2344 0.297669500664168 3422 828705
SGTC_1444 4112-3581 28 µM -0.531514844645098 0.305362853602282 no 2345 0.297531028609972 3418 2877249
SGTC_2897 9048598 12.99 µM -0.533621394878956 0.304658495812298 no 2346 0.29680175144293 3316 6467404
SGTC_1308 1187-1617 41.4 µM -0.534297938026957 0.304432436482722 no 2347 0.296567709295288 3367 2882570
SGTC_701 4424-0219 185 µM -0.53574646896341 0.303948677306157 no 2348 0.296066891576644 3469 2911779
SGTC_635 k038-0028 24.7 µM -0.536399453847135 0.303730715109737 no 2349 0.295841254393668 3358 4035102
SGTC_2983 9022671 12.99 µM -0.536935234380315 0.303551927092652 no 2350 0.295656175874428 3457 6405161
SGTC_2702 st077768 96.8 µM -0.537061790143062 0.303509702757057 no 2351 0.295612466579043 3379 6484119
SGTC_2551 apiole 73.87 µM -0.538949394727872 0.302880229949781 no 2352 0.29496088654077 3331 10659 A possible DNA adduct former.
SGTC_3045 9092950 49.47 µM -0.539146489320446 0.302814537138555 no 2353 0.294892889859264 3484 44120432
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.540667276921554 0.302307864200885 no 2354 0.294368468587241 3330 6857784
SGTC_1951 sophoraflavanone G 9.2 µM -0.541515837031245 0.302025319238776 no 2355 0.294076042385375 3349 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1473 k844-0725 134 µM -0.542444827203822 0.301716129554894 no 2356 0.293756052860191 3491 54682906
SGTC_3076 9116187 49.47 µM -0.542683130178981 0.301636839685832 no 2357 0.293673995665644 3388 27241210
SGTC_2754 granisetron 64.02 µM -0.542787484780728 0.301602121027651 no 2358 0.293638065565397 3467 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2626 ethyl orsellinate 100 µM -0.542944542732868 0.301549871413071 no 2359 0.293583993128549 3348 75653 A natural product.
SGTC_1745 st081495 74 µM -0.544998924478637 0.300866800623475 no 2360 0.292877128660448 3417 13842402 YBL026W LSM2
SGTC_447 ml7 120 µM -0.547590150715359 0.300006228686094 no 2361 0.291986676924232 3450 4216 Selective myosin light chain kinase inhibitor.
SGTC_1666 st014829 29 µM -0.547983406619287 0.299875721895959 no 2362 0.291851648292907 3409 3858230
SGTC_303 1348-1668 34.2 µM -0.548246989835648 0.299788262963918 no 2363 0.291761160454517 3413 5380509
SGTC_2549 cedrol 20.94 µM -0.548590996130445 0.299674136415389 no 2364 0.291643083127512 3427 6708665 A sedative which affects the nervous system.
SGTC_854 0422-0053 192 µM -0.549506004924227 0.29937067154656 no 2365 0.291329122373654 3444 3596728
SGTC_2594 a-mangostin 100 µM -0.550208105032975 0.299137912894912 no 2366 0.291088322530779 3471 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_87 0100-0052 35.5 µM -0.550891017960867 0.298911593971319 no 2367 0.29085419255573 3489 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_125 0133-0007 11.75 µM -0.554133375986772 0.297838131979567 no 2368 0.289743784962039 3503 26541
SGTC_636 0kpi-0074 126 µM -0.554420597168413 0.297743125200297 no 2369 0.289645516556968 3417 616434
SGTC_2085 5307070 144.047 µM -0.557450887397397 0.296741611894687 no 2370 0.288609702829697 3366 2840351
SGTC_2749 bexarotene 57.39 µM -0.558013290386293 0.296555907086054 no 2371 0.288417654401341 3395 82146 An retinoic acid receptor inhibitor.
SGTC_1487 3970-0795 2.82 µM -0.559573492852073 0.296041009010401 no 2372 0.287885194683562 3471 3765103
SGTC_2283 7944793 200 µM -0.561198702200459 0.295505094122983 no 2373 0.287331043791284 3424 2970533
SGTC_1804 st050076 49.1 µM -0.562177967088867 0.295182395810879 no 2374 0.28699738572227 3464 3895976
SGTC_1146 3579-1023 7 µM -0.563030851304397 0.294901476127124 no 2375 0.286706938062896 3478 X1146
SGTC_1495 4469-0029 237 µM -0.564964555215495 0.294265017045116 no 2376 0.286048936554601 3455 793680
SGTC_1920 st075728 45.7 µM -0.566376431220311 0.293800713464709 no 2377 0.285568956545284 3508 3400306
SGTC_744 1594-0068 283 µM -0.566743566454511 0.293680034472343 no 2378 0.285444208431746 3446 668392
SGTC_2188 6126565 140.678 µM -0.567534261232375 0.293420207511543 no 2379 0.285175628061432 3452 874518
SGTC_1669 st015249 58.4 µM -0.569025449710004 0.292930484226571 no 2380 0.284669434502343 3521 722793
SGTC_2991 9074669 71.4286 µM -0.570186651325622 0.29254939527958 no 2381 0.284275554411139 3495 17333109
SGTC_2629 bisabolol 100 µM -0.571358762260879 0.292164959864052 no 2382 0.283878238262837 3500 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_736 0958-0254 92.6 µM -0.571695221170199 0.292054649653079 no 2383 0.283764236268532 3510 6812352
SGTC_1831 st055328 12 µM -0.572083918309974 0.291927236944938 no 2384 0.283632561750911 3489 1103068
SGTC_550 4123-0385 25.7 µM -0.572765598222988 0.291703848683014 no 2385 0.283401707488272 3423 5731123
SGTC_924 2046-0044 21.3 µM -0.573638312889384 0.291417974186113 no 2386 0.283106289913144 3478 3623589
SGTC_748 act1.228 77.9 µM -0.575966607427349 0.29065593667916 no 2387 0.282318876272477 3459 4421505 YNR035C ARC35
SGTC_1066 ketoconazole 628 nM -0.580522059623859 0.289167665331519 no 2388 0.280781307519392 3520 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1016 4226-1401 38 µM -0.580768488297347 0.28908725906361 no 2389 0.280698247822195 3484 2901613
SGTC_647 0140-0236 81 µM -0.581403458171538 0.288880125643063 no 2390 0.280484283655196 3479 990837
SGTC_1785 bathophenanthroline 24 µM -0.583795552418973 0.28810042885501 no 2391 0.27967893545324 3397 72812 An iron chelator.
SGTC_651 3253-0966 34.4 µM -0.585006402998013 0.287706134241235 no 2392 0.279271705702335 3453 781462
SGTC_787 4152-0075 138 µM -0.586228831222544 0.287308328394226 no 2393 0.278860874702739 3440 9566539
SGTC_2602 kawain 100 µM -0.586781573810388 0.287128538915854 no 2394 0.2786752067845 3504 5369129
SGTC_495 decylubiquinone 155 µM -0.587392008705532 0.286930045894182 no 2395 0.27847022981019 3462 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2740 felodipine 17.08 µM -0.58786792189372 0.28677533994818 no 2396 0.278310474643928 3462 3333 L-type calcium channel blocker
SGTC_1027 k015-0025 8.67 µM -0.58864786452094 0.2865218881434 no 2397 0.278048759117237 3486 3598955
SGTC_3342 9147791 14.508 µM -0.590707008961603 0.285853255357326 no 2398 0.277358375460514 3486 1838168
SGTC_838 0109-0203 71.4 µM -0.591244593663367 0.285678816353781 no 2399 0.277178273778341 3502 759422
SGTC_2344 7990960 76.95 µM -0.592035336545766 0.285422323001942 no 2400 0.276913463037117 3446 140813
SGTC_2258 7960471 200 µM -0.592717070604074 0.285201276918228 no 2401 0.276685257589579 3456 2974708
SGTC_662 k832-1615 104 µM -0.592937981259157 0.285129666146947 no 2402 0.276611329151534 3481 5878478
SGTC_306 1672-3436 11.6 µM -0.593870867221792 0.284827354810267 no 2403 0.276299242772684 3527 6797378
SGTC_2711 st079103 59.1 µM -0.59423086250116 0.284710735529318 no 2404 0.276178856661961 3459 54693780
SGTC_1803 st050068 52.4 µM -0.594456264265006 0.28463772897739 no 2405 0.276103493110426 3586 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2586 curcumin 80 µM -0.594537721193731 0.284611347667095 no 2406 0.276076260299563 3495 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_146 3448-8650 53.125 µM -0.595374275748911 0.284340481820866 no 2407 0.275796658383114 3501 2891488 YIL048W NEO1
SGTC_876 0720-0963 56.8 µM -0.596228453149904 0.284064037101761 no 2408 0.275511310032724 3537 765861
SGTC_1057 3448-5381 134 µM -0.596352269171359 0.284023976137748 no 2409 0.275469959837824 3505 5497911
SGTC_802 4112-3352 742 µM -0.597494746934238 0.283654452373441 no 2410 0.275088556572872 3548 704594
SGTC_577 r071-0003 38.6 µM -0.597684071480551 0.283593239366923 no 2411 0.275025377846687 3516 4568517 YMR134W ERG29
SGTC_62 0180-0423 3.232 µM -0.599234816422031 0.283092086020582 no 2412 0.274508154259542 3485 30102 YGL099W LSG1
SGTC_256 clotrimazole 625 nM -0.599263556329156 0.283082802174154 no 2413 0.274498573102877 3499 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3282 9108498 15.4605 µM -0.601043999354742 0.282507951119128 no 2414 0.273905340478002 3470 16459645
SGTC_3252 9135871 49.47 µM -0.601282743664897 0.282430910521641 no 2415 0.273825840566147 3545 17682838
SGTC_2981 9013952 38.96 µM -0.601646070194722 0.282313687778219 no 2416 0.273704877687799 3454 2996344
SGTC_471 1-acyl-paf 4 µM -0.601760122366337 0.282276895105048 no 2417 0.273666911569136 3462 16759367
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.602186726239749 0.282139295240205 no 2418 0.273524925159547 3525 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.602608577380707 0.282003260116995 no 2419 0.273384556463813 3483 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_908 3448-7491 47.7 µM -0.602918449168302 0.281903355313549 no 2420 0.273281471023568 3553 1203031
SGTC_1150 3909-7983 10.9 µM -0.603357605364752 0.281761797538788 no 2421 0.273135409361997 3455 23965914
SGTC_2300 7976697 71.57 µM -0.604409160957729 0.281422978024807 no 2422 0.272785823315156 3431 2236109
SGTC_2114 5491910 81.25 µM -0.604916458089691 0.28125959321619 no 2423 0.272617253534194 3561 2849228
SGTC_2755 lomerizine 42.69 µM -0.605954794524114 0.280925319846995 no 2424 0.272272385988189 3506 3949 A calcium channel blocker.
SGTC_259 usnic acid 108.925 µM -0.60676493169384 0.280664644472572 no 2425 0.272003461968133 3599 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_127 0180-0333 59.125 µM -0.606905356988188 0.280619472154289 no 2426 0.271956861403642 3530 771601
SGTC_1232 0279-0259 161 µM -0.607987989296905 0.280271326756733 no 2427 0.271597719931682 3527 1560000
SGTC_16 erodoxin 22.806 µM -0.609316342098161 0.27984445029854 no 2428 0.271157388521015 3562 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1771 st048882 4.1505 µM -0.609387681337072 0.279821533807763 no 2429 0.271133750581188 3416 4580403
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.609774832165378 0.279697184209694 no 2430 0.271005487796738 3516 756377
SGTC_3016 9080866 49.47 µM -0.610601525479016 0.279431747054597 no 2431 0.27073170627392 3522 17066299
SGTC_1478 0453-0656 35.7 µM -0.61194991922718 0.278999063473684 no 2432 0.27028544626498 3565 5258496
SGTC_2589 lobaric acid 100 µM -0.612411609983263 0.278850987305776 no 2433 0.270132731160283 3480 73157 A novel microtubule depolymerizer.
SGTC_63 0099-0242 26.702 µM -0.614080816886775 0.278315948773674 no 2434 0.269580961973059 3549 3898502 YLR359W ADE13
SGTC_980 1473-0395 201 µM -0.616662280975459 0.277489486943244 no 2435 0.268728752620292 3516 768876
SGTC_2032 5185112 25.99 µM -0.616672535676792 0.277486206269768 no 2436 0.268725369973804 3460 5718189
SGTC_187 1488-2104 32.728 µM -0.618488013101417 0.276905699557967 no 2437 0.26812684847819 3569 2852859
SGTC_390 dec-rvkr-cmk 16.7 µM -0.618952479847001 0.276757279907162 no 2438 0.267973832239134 3550 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_890 0929-0006 47.2 µM -0.619915893741815 0.276449546758586 no 2439 0.267656580622025 3484 1378169
SGTC_658 3253-0951 102 µM -0.621387597131193 0.275979780238592 no 2440 0.267172315323515 3545 1184878
SGTC_680 0417-1641 114 µM -0.622830242283441 0.275519669920313 no 2441 0.266698041292835 3507 2835990
SGTC_1974 st069448 26.9 µM -0.622970491687159 0.27547495957907 no 2442 0.266651956578189 3520 6323587 YNR016C ACC1
SGTC_140 0062-0056 502.533 µM -0.623121184651979 0.275426923895474 no 2443 0.26660244468886 3530 3758964
SGTC_2482 5981709 142.65 µM -0.625453073438528 0.274684124459598 no 2444 0.265836869084456 3519 877755
SGTC_2244 6635614 200 µM -0.627477901775483 0.274039938350474 no 2445 0.265173008566892 3436 836499
SGTC_2226 7298446 200 µM -0.628121193290694 0.273835435667971 no 2446 0.264962275276096 3560 3283010
SGTC_2387 9077560 195.08 µM -0.628308657707495 0.273775854842105 no 2447 0.264900880575621 3514 5303272
SGTC_2839 9003951 25.97 µM -0.6331603854313 0.272236089722496 no 2448 0.263314456092783 3558 2990634
SGTC_1029 k015-0030 64.7 µM -0.633265291169827 0.272202843979856 no 2449 0.263280207535665 3566 2208316
SGTC_404 fumagillin 50 µM -0.633364335792914 0.272171457538938 no 2450 0.263247874543865 3531 12015870 A methionine aminopeptidase binder.
SGTC_2310 7668677 200 µM -0.635773984256016 0.271408414111802 no 2451 0.262461873230977 3617 2197143
SGTC_91 0417-1751 58.384 µM -0.636438074037854 0.271198309802659 no 2452 0.26224546569522 3642 6795624
SGTC_713 1488-1073 324 µM -0.637995874434727 0.270705772317502 no 2453 0.261738182826812 3555 3312542
SGTC_2895 9054447 58.44 µM -0.639151055688777 0.270340821564378 no 2454 0.261362334400997 3582 2697450
SGTC_1596 piperlongumine 63 µM -0.63919669161012 0.27032640908301 no 2455 0.261347492044755 3596 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_58 0957-0393 9 µM -0.640958734933296 0.269770224322381 no 2456 0.260774746785228 3557 6997992
SGTC_454 lyso-paf C-16 6.67 µM -0.641428976686665 0.269621890567821 no 2457 0.26062200579503 3522 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1116 jasmonic acid 1.58368 µM -0.642423202609728 0.269308405059334 no 2458 0.260299219216287 3627 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2854 9024559 71.43 µM -0.64315413602935 0.269078053928152 no 2459 0.260062044945332 3554 3163529
SGTC_1215 3852-0577 11.2 µM -0.645090035685515 0.268468439989374 no 2460 0.259434420368145 3642 2884876
SGTC_1643 st009866 20.2 µM -0.645391531430482 0.268373561644736 no 2461 0.25933674498795 3589 3156273 YOR207C RET1
SGTC_3312 9133330 71.43 µM -0.646032391923572 0.268171943911073 no 2462 0.259129188967389 3610 17617324
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.646551444566242 0.268008703388463 no 2463 0.258961145925644 3607 16623 A steroid.
SGTC_3043 9092303 49.47 µM -0.647696833622453 0.267648659011557 no 2464 0.258590526305253 3549 25236084
SGTC_3255 9139072 49.47 µM -0.648402936097749 0.267426822581282 no 2465 0.258362185903838 3610 17646060
SGTC_3095 9117207 49.47 µM -0.649096843118079 0.267208907986055 no 2466 0.25813789111223 3568 17015229
SGTC_1477 0139-0234 16 µM -0.650561344484273 0.266749290264943 no 2467 0.257664845134282 3605 620880
SGTC_2950 9072895 21.46 µM -0.650790479202184 0.266677415007565 no 2468 0.257590873476802 3568 17332245
SGTC_1642 st009582 77.7 µM -0.65110003046678 0.266580330139607 no 2469 0.257490958427564 3611 6739311
SGTC_2368 9071271 200 µM -0.652459784136525 0.266154081048176 no 2470 0.257052304081721 3575 27209959
SGTC_1092 toremifene 6.32 µM -0.652537436864509 0.266129749261981 no 2471 0.25702726517387 3609 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1199 1638-0010 4.46 µM -0.652659437064695 0.266091523867995 no 2472 0.256987929108495 3574 3111136
SGTC_3267 9137951 49.47 µM -0.652973426197332 0.265993156831811 no 2473 0.256886705178267 3579 16643986
SGTC_585 0kpi-0023 191 µM -0.654236232347605 0.265597728936524 no 2474 0.256479810889344 3565 64601
SGTC_2396 5342950 42.78 µM -0.65454063953162 0.265502453228208 no 2475 0.25638177676964 3591 1886677
SGTC_2256 7954252 200 µM -0.655260221978107 0.265277301723319 no 2476 0.256150113411422 3553 2972920
SGTC_1493 4348-0038 111 µM -0.655478643598919 0.265208978553162 no 2477 0.256079816057781 3636 800424
SGTC_1668 st014914 51.6 µM -0.655635247755013 0.265159997637447 no 2478 0.256029420383963 3609 2839556
SGTC_1206 3978-0017 132 µM -0.655824650221546 0.265100764567655 no 2479 0.255968477031383 3657 3873677
SGTC_1386 3228-0095 33.8 µM -0.656187588121509 0.264987279410762 no 2480 0.255851716955648 3589 870181
SGTC_327 1273-0057 3.96 µM -0.657153142155836 0.264685485597996 no 2481 0.255541225766107 3553 3108138
SGTC_1778 st046819 58.9 µM -0.658857737580832 0.264153123854475 no 2482 0.254993563445982 3636 671715
SGTC_2806 7952793 58.44 µM -0.658881897637042 0.264145582355617 no 2483 0.254985805578804 3618 2972490
SGTC_3141 9094609 49.47 µM -0.65911793839798 0.264071908615096 no 2484 0.254910018673426 3561 25236309 YDL196W YDL196W
SGTC_2997 9067075 71.4286 µM -0.660093614354294 0.263767488869133 no 2485 0.254596878141494 3587 27209819
SGTC_362 0310-0100 9.03 µM -0.660098495908183 0.263765966230118 no 2486 0.254595311926847 3626 790235
SGTC_1463 k081-0032 34.1 µM -0.66188834751412 0.263207983608358 no 2487 0.254021390078958 3484 977755
SGTC_2673 kobusone 100 µM -0.664024255941817 0.2625429084742 no 2488 0.253337393333516 3671 6710676 An epoxy ketone and protein crosslinker.
SGTC_887 0885-0007 9.62 µM -0.664558467226674 0.262376701342321 no 2489 0.253166470638416 3633 5719458
SGTC_1280 0880-0253 10.1 µM -0.665792543846167 0.261992953874397 no 2490 0.252771855681161 3597 6836607
SGTC_3108 9121785 49.47 µM -0.666268399002743 0.261845059244185 no 2491 0.252619780245934 3575 17140271
SGTC_2222 6885208 172.143 µM -0.667040162800255 0.261605287996939 no 2492 0.252373239807783 3592 609514
SGTC_1100 amiodarone 5.07 µM -0.670299880140806 0.260593805034534 no 2493 0.251333321760381 3657 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3354 9151612 71.43 µM -0.671786105407544 0.260133301798325 no 2494 0.250859937772142 3623 27261949
SGTC_297 0986-0032 24 µM -0.672024435681138 0.260059494797318 no 2495 0.250784070109985 3606 2847425
SGTC_484 loperamide 105 µM -0.674159161993774 0.259398886653827 no 2496 0.250105064897149 3591 3955 An opioid-receptor agonist.
SGTC_1548 st061468 90.8 µM -0.675969425773504 0.258839366068935 no 2497 0.249530028498762 3631 390799
SGTC_1944 st076371 56.9 µM -0.676102332302666 0.258798311627518 no 2498 0.249487837989176 3618 24208455
SGTC_2875 9039966 71.43 µM -0.676121797806023 0.258792299072904 no 2499 0.24948165908125 3672 6463691
SGTC_85 0868-0259 160.055 µM -0.676844370089275 0.258569160249899 no 2500 0.249252351503974 3586 83173
SGTC_2265 7929201 200 µM -0.679059061076133 0.257885858804533 no 2501 0.248550220322016 3643 1265108
SGTC_3054 9094397 49.47 µM -0.679150065628036 0.257857801107913 no 2502 0.248521391389364 3637 2598354
SGTC_2228 7354201 200 µM -0.679788637051229 0.257660967132458 no 2503 0.248319151272649 3664 753451
SGTC_43 0570-0105 72.5 µM -0.680330545223075 0.257493989959651 no 2504 0.248147593942227 3678 1114046 YDL195W SEC31
SGTC_619 1652-1634 108 µM -0.680869452578577 0.257327993184602 no 2505 0.247977049323654 3607 5400454
SGTC_1611 st001856 99.4 µM -0.681188327888833 0.257229797909963 no 2506 0.247876166322668 3615 647478
SGTC_514 4466-0038 2.65 nM -0.681362456069213 0.257176184658968 no 2507 0.247821086410286 3599 5722064
SGTC_2149 5554786 194.827 µM -0.681413742994323 0.257160394762696 no 2508 0.247804864668238 3682 745063 YPR165W RHO1
SGTC_3122 9126309 49.47 µM -0.682305642279286 0.256885883041993 no 2509 0.247522853028484 3685 17591206
SGTC_2894 9048625 32.47 µM -0.683166971612472 0.25662092505184 no 2510 0.247250670214716 3702 4092861
SGTC_505 gw-5074 63.9 µM -0.683642899778888 0.256474583384743 no 2511 0.247100344068675 3654 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3341 9147222 25.867 µM -0.685636283917042 0.25586211666175 no 2512 0.24647124752103 3627 1939759
SGTC_115 0527-0192 112.043 µM -0.685641836266337 0.255860411770653 no 2513 0.24646949644208 3686 4233931
SGTC_1266 0828-0227 32.9 µM -0.68582010828939 0.255805675141005 no 2514 0.246413277227997 3629 3913820
SGTC_1834 st055981 52.8 µM -0.68617005651194 0.255698244841773 no 2515 0.246302938823758 3684 471719 YDL150W RPC53
SGTC_1363 1636-0063 10.4 µM -0.687390619780756 0.255323729647017 no 2516 0.245918303549958 3686 6072185
SGTC_1225 1216-0074 20.6 µM -0.690353316645471 0.254415855748976 no 2517 0.244986013278941 3655 4241466
SGTC_2014 4013930 200 µM -0.692768902592196 0.253676889718404 no 2518 0.244227295314128 3646 64556
SGTC_1573 oleylamine 1.06 µM -0.693054010725723 0.253589745054329 no 2519 0.244137828582203 3681 5356789 An amine of the fatty acid oleic acid.
SGTC_1304 1165-0502 251 µM -0.693154533583823 0.253559023512294 no 2520 0.244106288794643 3674 767425
SGTC_1300 1094-0077 113 µM -0.693349660744648 0.253499394823956 no 2521 0.244045072483026 3627 5532636
SGTC_3286 9117135 37.221 µM -0.693950910130873 0.253315706044069 no 2522 0.24385649746519 3636 3438150
SGTC_2135 5326629 150.42 µM -0.696376146959433 0.252575478551115 no 2523 0.243096648537391 3654 5020077
SGTC_2239 6685329 187.64 µM -0.697603733214516 0.252201231180355 no 2524 0.24271252313334 3670 805680
SGTC_1018 4259-0013 28.1 µM -0.697833071693844 0.252131346472745 no 2525 0.242640797013906 3698 6801262
SGTC_1924 st058459 75.1 µM -0.699028819512339 0.251767140151389 no 2526 0.242267010206365 3636 688683
SGTC_2433 5607874 27.82 µM -0.699894348873514 0.251503686685512 no 2527 0.241996643422752 3674 2252428
SGTC_403 arphamenine a 50 µM -0.701855023908517 0.250907427349549 no 2528 0.241384789955754 3639 5487158 An arginine aminopeptidase inhibitor.
SGTC_2438 5259590 200 µM -0.702522144412993 0.2507047205908 no 2529 0.241176798344264 3706 1201127
SGTC_1191 1487-1166 10.6 µM -0.702668014976739 0.250660408898396 no 2530 0.241131332506656 3745 3955771
SGTC_2585 alliin 100 µM -0.703722993979869 0.250340057180409 no 2531 0.240802648892801 3749 87310 A garlic compound which reacts with lipids.
SGTC_1564 D-Arginine 115 µM -0.705784413394498 0.249714719764335 no 2532 0.240161108244196 3653 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_3119 9125183 49.47 µM -0.70757953035203 0.249170842415865 no 2533 0.239603204106659 3568 22695334
SGTC_162 k030-0015 37.8 µM -0.707643171483312 0.249151572251167 no 2534 0.239583438082063 3739 1809920 YMR134W ERG29
SGTC_2041 5107442 45.335 µM -0.708054487442202 0.249027047288446 no 2535 0.239455710701125 3691 793005
SGTC_2449 5812982 45.77 µM -0.708642765863793 0.248849004912038 no 2536 0.239273095189519 3654 776185
SGTC_476 mead acid 10 µM -0.70982169977694 0.248492404807918 no 2537 0.238907355407066 3708 5312531 An omega 9 fatty acid.
SGTC_999 SEC7.066 22.7 µM -0.710162588668527 0.248389344615548 no 2538 0.238801658710968 3697 740511 YDR170C SEC7
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.71193892871083 0.247852676498278 no 2539 0.238251297295439 3825 16725076
SGTC_1672 st016598 6.51 µM -0.712866624549027 0.247572647123523 no 2540 0.237964146783666 3708 4665860 YNL267W PIK1
SGTC_2441 5730946 39.09 µM -0.712957601968944 0.247545194262402 no 2541 0.237935996681922 3729 1774275
SGTC_383 2324-0395 7.37 µM -0.713479220614914 0.247387824800497 no 2542 0.237774633442733 3714 3146421
SGTC_3028 9087778 49.47 µM -0.713493250857512 0.24738359269246 no 2543 0.237770294002558 3674 17217395
SGTC_520 3584-0023 682 µM -0.714839471011957 0.246977696435372 no 2544 0.237354121146605 3714 1340790
SGTC_1388 3346-4487 254 µM -0.714874163551044 0.246967241066563 no 2545 0.237343401523638 3753 3345614
SGTC_3260 9137109 49.47 µM -0.716475277911239 0.246484967421547 no 2546 0.23684896370231 3562 17478346
SGTC_137 0438-0332 85.389 µM -0.716608702176469 0.24644480132283 no 2547 0.236807786726116 3730 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2047 4141938 200 µM -0.717952781554335 0.246040374790545 no 2548 0.236393200830911 3688 3807862
SGTC_772 k072-0172 35.3 µM -0.71966575939446 0.245525465092029 no 2549 0.235865406551219 3702 5861980
SGTC_1659 st012954 42.1 µM -0.722637297350052 0.244633615541783 no 2550 0.234951373753331 3690 24207262
SGTC_2771 fluoxetine 41.05 µM -0.723239920843029 0.244452962787259 no 2551 0.234766248256698 3695 3386 A selective serotonin reuptake inhibitor.
SGTC_1474 0330-0125 5.35 µM -0.723798622299844 0.244285541087381 no 2552 0.234594687639639 3710 X1474
SGTC_2843 9000894 45.46 µM -0.723845305187089 0.244271554789873 no 2553 0.234580355851649 3614 2242070
SGTC_499 genistein 192 µM -0.725165066145503 0.243876330113208 no 2554 0.2341753856625 3720 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2076 5212012 200 µM -0.726121843432598 0.243590022925999 no 2555 0.233882039638499 3629 604802
SGTC_3238 9133470 49.47 µM -0.726127125787896 0.24358844273166 no 2556 0.233880420644188 3711 3534688
SGTC_1277 0873-0036 22 µM -0.728097316236929 0.24299945483274 no 2557 0.233277008295743 3771 5965735
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.729664128358321 0.242531607244703 no 2558 0.232797756464325 3749 364106
SGTC_719 2810-4230 27.3 µM -0.731075917918682 0.242110467328738 no 2559 0.232366391458454 3713 721079
SGTC_796 1234-0020 70.7 µM -0.731361414934254 0.242025351169094 no 2560 0.232279213400363 3679 46495034
SGTC_1090 efavirenz 20.7 µM -0.731778729634791 0.241900964974881 no 2561 0.232151816846528 3785 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1755 st041960 45.185 µM -0.733838879678307 0.241287418392742 no 2562 0.23152347075953 3753 2257073
SGTC_916 4466-0038 42 nM -0.735032101208375 0.240932444491934 no 2563 0.23115997203391 3795 5722064 YGL116W CDC20
SGTC_442 cape 100 µM -0.735253352707072 0.240866655165519 no 2564 0.231092605786717 3687 5281787
SGTC_2001 4023502 57.655 µM -0.735628703592448 0.240755066609226 no 2565 0.23097834470802 3749 108941 YCR052W RSC6
SGTC_1417 3966-0327 90.4 µM -0.735886310354021 0.240678498639966 no 2566 0.230899944533512 3801 651118
SGTC_929 2805-0021 398 µM -0.737495609326577 0.240200469925509 no 2567 0.230410506151464 3799 3098024
SGTC_1690 st023502 41.2 µM -0.738090890065331 0.240023777980769 no 2568 0.230229609633371 3711 24207482
SGTC_1458 k015-0034 6.33 µM -0.738130329584171 0.240012073999057 no 2569 0.230217627386098 3772 3598957
SGTC_3136 9095672 49.47 µM -0.738734961435951 0.23983268378854 no 2570 0.230033975904958 3548 17217380
SGTC_3332 9141069 11.198 µM -0.738929065753651 0.239775109854342 no 2571 0.229975035854784 3692 17332883
SGTC_3090 9117696 49.47 µM -0.739094246328919 0.239726121028313 no 2572 0.229924885197361 3696 7923821
SGTC_3246 9135460 32.98 µM -0.741120078462771 0.239125749469902 no 2573 0.229310318225521 3669 41446951
SGTC_1043 0916-0009 19.3 µM -0.74397809454373 0.238280152856361 no 2574 0.22844486379144 3759 3101130
SGTC_1036 k216-0215 33.5 µM -0.744175048430271 0.238221940815197 no 2575 0.228385290573073 3742 622330
SGTC_2748 diazoxide 86.69 µM -0.745423741208925 0.237853056302095 no 2576 0.228007798007512 3728 3019 A potassium channel activatior.
SGTC_1644 st010134 20.9 µM -0.746168590546691 0.237633164723272 no 2577 0.227782789668733 3743 3818134
SGTC_2994 9053520 71.4286 µM -0.746688872596379 0.237479635235461 no 2578 0.227625694058256 3768 4647384
SGTC_1352 1496-0991 99 µM -0.746844055122327 0.237433853129951 no 2579 0.227578849567832 3747 3000039
SGTC_3075 9116269 49.47 µM -0.747679998561573 0.237187315624874 no 2580 0.227326599194321 3742 17015205 YNL244C SUI1
SGTC_1053 3366-3204 134 µM -0.748510841328712 0.236942421824583 no 2581 0.227076044147745 3765 3632071 YPR165W RHO1
SGTC_3266 9136860 49.47 µM -0.749266130083875 0.236719918494249 no 2582 0.226848408888547 3683 4871271 YPR165W RHO1
SGTC_3111 9122088 49.47 µM -0.749682202852182 0.236597395175674 no 2583 0.226723064398222 3655 16876704
SGTC_1800 st050079 29.0735 µM -0.750874251253613 0.23624655915011 no 2584 0.226364168925431 3688 3645560
SGTC_2356 9061756 188.97 µM -0.751974095248503 0.235923114408245 no 2585 0.226033318652075 3756 20104043
SGTC_34 0469-0683 81.75 µM -0.752103563443247 0.235885056156231 no 2586 0.225994390584707 3743 3690923
SGTC_2140 5586273 200 µM -0.75395302833828 0.235341760206139 no 2587 0.225438713563592 3729 854421
SGTC_1832 st054113 55 µM -0.754686548301098 0.23512647397278 no 2588 0.225218539793493 3709 1251267
SGTC_642 0335-0876 158 µM -0.754825746678255 0.235085631887834 no 2589 0.225176771683279 3779 6812350
SGTC_1843 st055809 45.5 µM -0.754896005314133 0.235065018845684 no 2590 0.225155691419708 3787 16413835
SGTC_1145 3546-0597 10.2 µM -0.755296404283378 0.234947565644698 no 2591 0.225035577839388 3732 875334
SGTC_1977 st070720 65.3 µM -0.756297681400645 0.234653992589855 no 2592 0.224735368975513 3794 682188
SGTC_2808 7946468 45.46 µM -0.757115124992039 0.23441446975298 no 2593 0.224490446664191 3795 2970879
SGTC_2083 5306046 65.942 µM -0.757497878735334 0.234302363870842 no 2594 0.224375818136068 3800 539837
SGTC_1889 st059080 5.18 µM -0.757893092580376 0.234186639658728 no 2595 0.22425749288025 3737 176925 Isolated from Daphnopsis sellowiana.
SGTC_3339 9145883 14.936 µM -0.757941708920197 0.234172406291951 no 2596 0.2242429398133 3685 2030670
SGTC_2406 ethylparaben 405.7 µM -0.758045793611815 0.234141935110869 no 2597 0.224211784365683 3804 8434 A possible steroid mimic.
SGTC_2267 7931562 200 µM -0.758545632846161 0.233995635905651 no 2598 0.224062202807549 3678 934880
SGTC_1436 4092-1007 8.32 µM -0.758808975563588 0.233918577833517 no 2599 0.223983417846299 3758 2881121
SGTC_449 xestospongin c 11.1929 µM -0.758956324453536 0.233875467449154 no 2600 0.223939341943828 3780 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_955 1216-0110 33 µM -0.760068598146072 0.233550187696418 no 2601 0.223606790879092 3727 3619719
SGTC_3203 9113543 49.47 µM -0.761509912948986 0.233129054718584 no 2602 0.223176280118887 3863 17018012
SGTC_2425 5628681 7.85 µM -0.761874486548749 0.233022598016644 no 2603 0.223067459327688 3824 5714958
SGTC_1376 2910-0861 41.3 µM -0.761903252778619 0.233014199331222 no 2604 0.223058874243788 3749 1112859
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.762531063540461 0.232830943461233 no 2605 0.222871555299537 3849 4213774
SGTC_2841 9004761 38.96 µM -0.762622579061489 0.23280423707413 no 2606 0.222844257438494 3753 2991039
SGTC_1912 st060209 90.8 µM -0.762704452808052 0.232780345826809 no 2607 0.222819837204954 3791 688787
SGTC_1691 st019933 84.6 µM -0.762991173731463 0.232696689692923 no 2608 0.222734329847644 3736 6176082
SGTC_144 4161-2749 112.381 µM -0.763871789803341 0.232439858163285 no 2609 0.222471825043374 3702 797501 YMR168C CEP3
SGTC_1194 1488-0194 225 µM -0.765027673210956 0.232102984370918 no 2610 0.22212753311264 3733 1391452
SGTC_2935 9038016 29.96 µM -0.765472762700854 0.23197333879306 no 2611 0.221995039706637 3779 6463195
SGTC_1898 st060199 18.6 µM -0.765547402507417 0.231951601673805 no 2612 0.221972825487437 3779 688866
SGTC_67 0335-0847 266 µM -0.765764486022882 0.231888387562408 no 2613 0.221908224538708 3933 4552207 YOR254C SEC63
SGTC_2179 6298986 200 µM -0.766476918114319 0.23168099676489 no 2614 0.221696290393559 3715 738374
SGTC_539 4859-0462 2.54 µM -0.766612879331755 0.23164142985603 no 2615 0.221655857825319 3838 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_321 4534-3890 65.3 µM -0.767813696760287 0.231292136158251 no 2616 0.221298938019953 3805 699746
SGTC_2960 9079389 5.97 µM -0.768418260272365 0.231116392014838 no 2617 0.221119367659326 3754 16457355
SGTC_1866 st057638 64 µM -0.768576956755591 0.23107027194664 no 2618 0.221072244685617 3769 688802
SGTC_2801 7907800 81.82 µM -0.770781461404798 0.230430134567264 no 2619 0.220418238731498 3850 6620925
SGTC_1435 4092-0789 56.7 µM -0.771510166648212 0.230218753562952 no 2620 0.22020229932458 3788 2248285
SGTC_2006 4011487 200 µM -0.771611755838368 0.230189293439877 no 2621 0.220172204733973 3838 45595294
SGTC_2820 7989630 71.43 µM -0.772438722001257 0.229949557760439 no 2622 0.219927313602803 3682 2984098
SGTC_1485 3909-9022 254 µM -0.773016669524435 0.229782095035482 no 2623 0.219756257688122 3821 714516
SGTC_2328 6201408 200 µM -0.774303487005343 0.229409479668024 no 2624 0.219375671044684 3804 2890418
SGTC_220 paclitaxel 373.376 µM -0.776789824372205 0.228690487369214 no 2625 0.218641390604945 3722 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1347 1493-0251 600 nM -0.77817696753908 0.228289907584351 no 2626 0.218232346553655 3832 3986378
SGTC_2883 9059145 45.46 µM -0.77854984463559 0.228182295275288 no 2627 0.218122466919259 3789 16476510
SGTC_1756 st041558 35.5 µM -0.779361745896256 0.227948079302588 no 2628 0.217883325731061 3851 3955792
SGTC_1692 fluoroquinolonic acid 71 µM -0.779858425394893 0.227804864698257 no 2629 0.217737106004609 3840 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1618 st003135 44.5 µM -0.780936082292366 0.227494302878102 no 2630 0.217420044449604 3722 1270615
SGTC_2866 9034245 58.44 µM -0.782452183389363 0.227057793106319 no 2631 0.216974438151928 3784 6462273
SGTC_2119 5528445 120.635 µM -0.782519768209147 0.227038345356058 no 2632 0.2169545861925 3813 791935
SGTC_604 1000-0114 314 µM -0.784127331694161 0.226576040716727 no 2633 0.216482699696743 3802 1572745
SGTC_457 grayanotoxin iii 135 µM -0.785021098547855 0.226319240420078 no 2634 0.216220599186889 3732 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2671 danthron 100 µM -0.787123388819791 0.225715851471053 no 2635 0.215604819501849 3784 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.788030832882718 0.225455682825001 no 2636 0.215339335514757 3840 6708784 An antioxidant flavonoid
SGTC_603 3794-0023 45.9 µM -0.788415728825193 0.225345382570548 no 2637 0.215226786758953 3803 3802260
SGTC_1397 3532-0190 20.1 µM -0.788705960716889 0.225262230557803 no 2638 0.215141941629133 3726 5322280
SGTC_192 3455-0609 60.9 µM -0.789443564346624 0.22505098387464 no 2639 0.21492640118644 3886 3769639
SGTC_910 3454-3003 490 µM -0.790366751760075 0.22478674499464 no 2640 0.21465680677867 3733 820824
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.790452473086377 0.224762218377634 no 2641 0.214631783928056 3840 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_329 k048-0121 21.3 µM -0.791338196452341 0.22450888375068 no 2642 0.214373332335623 3820 6832902
SGTC_2297 7971671 152.32 µM -0.792339957135545 0.224222555475451 no 2643 0.214081239610565 3796 909016
SGTC_714 4296-0578 26.1 µM -0.792471763434607 0.224184897378382 no 2644 0.2140428248661 3858 1589775
SGTC_1357 1503-1303 39.5 µM -0.792662697693651 0.224130352328082 no 2645 0.213987184484019 3797 292895
SGTC_2144 5628481 200 µM -0.795010451443155 0.223460275375512 no 2646 0.213303711296596 3816 2818399
SGTC_2930 9013230 14.89 µM -0.79757853462129 0.222728620633718 no 2647 0.212557555843283 3851 2995857
SGTC_2948 9070189 9.45 µM -0.799530295880053 0.222173472204486 no 2648 0.211991493462368 3737 6473636 YDL196W YDL196W
SGTC_2907 7721985 69.9 µM -0.79970641101991 0.222123417838051 no 2649 0.211940458818399 3844 3267881
SGTC_386 1509-0011 3.07 µM -0.800432047930992 0.221917249667357 no 2650 0.211730259578959 3876 3107280
SGTC_331 k048-0133 24.5 µM -0.801341058371836 0.221659135612187 no 2651 0.21146711374003 3803 6813582
SGTC_1955 wogonin 32.4 µM -0.801843014813004 0.221516678333814 no 2652 0.211321886467539 3916 5281703 A flavanone.
SGTC_2306 7482397 179.52 µM -0.801872382038451 0.221508345416692 no 2653 0.211313391679069 3812 891448
SGTC_411 enrofloxacin 100 µM -0.802793697199909 0.221247014283438 no 2654 0.211046992868578 3900 71188 A bacterial gyrase inhibitor.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.804492428487601 0.220765631642404 no 2655 0.210556320177749 3876 688798
SGTC_750 4073-0104 132 µM -0.804636897164836 0.220724720127405 no 2656 0.210514621807901 3674 22330957
SGTC_1633 st005664 67.9 µM -0.805084263236363 0.220598059839499 no 2657 0.210385528120654 3849 2063822
SGTC_677 0929-0063 136 µM -0.80541470700852 0.220504529861362 no 2658 0.210290203834827 3807 1539583
SGTC_1219 1469-0211 33.1 µM -0.805581725983763 0.220457264864555 no 2659 0.210242032929823 3830 6822282
SGTC_1380 2291-0730 164 µM -0.805944309233195 0.220354676773005 no 2660 0.210137480512572 3879 2999191
SGTC_2481 5478948 45.16 µM -0.806302861877055 0.220253256004356 no 2661 0.210034120378064 3883 77792
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.806818818791048 0.220107358595558 no 2662 0.20988543767431 3801 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2110 5483698 200 µM -0.807747085936007 0.219845011636277 no 2663 0.209618095835475 3829 2848765 YHR062C RPP1
SGTC_2075 5212009 200 µM -0.808565247560575 0.219613931587955 no 2664 0.209382630627825 3722 780898
SGTC_2326 6164455 177.58 µM -0.809044587949275 0.219478612405762 no 2665 0.209244749801511 3840 2888790
SGTC_3180 9109287 49.47 µM -0.809965726247302 0.219218706903367 no 2666 0.208979937218825 3892 18891271
SGTC_2879 9041815 71.43 µM -0.811223972624884 0.218863970092026 no 2667 0.208618530595109 3844 4942971
SGTC_2591 skatole 100 µM -0.811439521468648 0.218803233658804 no 2668 0.20855665539832 3896 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2133 5320837 200 µM -0.811968806837666 0.218654135040201 no 2669 0.208404765276891 3850 2841355
SGTC_180 1486-1293 102.781 µM -0.814734029238942 0.217876129018643 no 2670 0.207612285141623 3793 4140536
SGTC_369 0957-0393 4.5 µM -0.81629899733914 0.217436527556495 no 2671 0.207164573861611 3870 6997992
SGTC_2002 4023503 131 µM -0.816459917483954 0.217391353942488 no 2672 0.207118569693469 3859 4736863 YCR052W RSC6
SGTC_7 0192-1582 4.227 µM -0.816744712595979 0.217311419345015 no 2673 0.207037166719159 3900 252616
SGTC_3055 9094636 49.47 µM -0.818026035120179 0.216951995401747 no 2674 0.206671160595368 3843 25236176
SGTC_83 0170-0301 39.027 µM -0.818083293476361 0.216935941877398 no 2675 0.206654813857786 3783 3089716
SGTC_2695 st077686 51.995 µM -0.819708912077337 0.216480453768924 no 2676 0.206191034129123 3918 2876092
SGTC_1189 1431-2119 7.28 µM -0.820386091946558 0.216290875628203 no 2677 0.20599802076492 3881 3107275
SGTC_350 k064-0020 19.8 µM -0.822275422041884 0.21576246152709 no 2678 0.20546008082908 3827 2790705
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.823085581348584 0.215536102920322 no 2679 0.205229663818373 3909 165506
SGTC_387 norethindrone acetate 66.7 µM -0.823192840215473 0.215506145107551 no 2680 0.205199169889336 3863 541197
SGTC_2892 9047358 58.44 µM -0.823408922743106 0.215445799763198 no 2681 0.20513774533257 3856 6466771
SGTC_244 nsc-207895 1.295 µM -0.824873873097614 0.215036941808415 no 2682 0.204721600419055 3711 42640
SGTC_1329 1447-1697 50.6 µM -0.825211474953524 0.214942783279688 no 2683 0.204625769917862 3884 2840515
SGTC_1375 2910-0797 186 µM -0.825465409298127 0.214871975741526 no 2684 0.204553706578785 3883 742508
SGTC_22 0964-0034 14.468 µM -0.827474664975482 0.214312188997104 no 2685 0.203984038043273 3898 138402
SGTC_227 fluconazole 33.516 µM -0.827781814347376 0.214226690751827 no 2686 0.203897037758085 3867 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1354 1498-1681 81 µM -0.828359969797797 0.214065808967623 no 2687 0.203733334802492 3914 5754243
SGTC_2461 5755302 26.15 µM -0.829402909628518 0.21377577076666 no 2688 0.203438227804177 3911 2788904
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.829624354737096 0.213714217066218 no 2689 0.203375601225022 3904 61125 An anti-inflammatory.
SGTC_578 3460-0051 92 µM -0.82985263751699 0.213650773549456 no 2690 0.203311052936477 3939 2876744
SGTC_2744 captopril 92.04 µM -0.830189097195614 0.213557285909871 no 2691 0.203215939289431 3835 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1914 st062367 72.6 µM -0.830461111527164 0.213481722282556 no 2692 0.203139063089812 3888 978205
SGTC_2413 inermin 26.06 µM -0.832328847535755 0.212963299620951 no 2693 0.202611675943566 3989 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2259 7964009 200 µM -0.833502571198287 0.21263788839895 no 2694 0.202280674164132 3927 313134
SGTC_983 1491-0821 12.2 µM -0.833828873126288 0.212547473817564 no 2695 0.202188711257263 3893 46495113
SGTC_2566 crystal violet carbinol 226 nM -0.835220858203236 0.212162022768505 no 2696 0.201796683876266 3931 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_480 am 92016 50 µM -0.836776881114983 0.211731632531002 no 2697 0.20135899741561 3835 2129 K+ channel blocker.
SGTC_1722 st034304 3.6505 µM -0.837294637323303 0.211588536432069 no 2698 0.201213486439127 3899 4036148 YLR033W RSC58
SGTC_709 3807-1509 243 µM -0.83729515934818 0.211588392184782 no 2699 0.201213339760302 3946 1886677 YPL242C IQG1
SGTC_512 prima-1 270 µM -0.839889407250746 0.210872254075768 no 2700 0.200485198693311 3904 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2044 5102272 200 µM -0.841374333265429 0.210462982972697 no 2701 0.200069129865755 3900 592666
SGTC_2828 7998861 71.43 µM -0.842005402277566 0.21028919079388 no 2702 0.199892464779655 3806 2988188
SGTC_1353 1498-1206 8.11 µM -0.84498286401043 0.209470355293992 no 2703 0.199060203330741 3940 6756808
SGTC_3100 9120536 49.47 µM -0.845073654126983 0.20944541649722 no 2704 0.19903485848163 3727 16421196
SGTC_429 1112-0049 25.5 µM -0.846023177641251 0.209184700134059 no 2705 0.198769907273405 3873 2836170
SGTC_2191 5911152 200 µM -0.847046160212264 0.208904027596553 no 2706 0.198484696429403 3895 2875902
SGTC_2847 9005661 71.43 µM -0.847406181425676 0.208805302501249 no 2707 0.198384380115896 3877 2991449
SGTC_632 0781-2353 4.65 µM -0.847771188874343 0.208705238150547 no 2708 0.198282705676681 3956 6811515 YHR007C ERG11
SGTC_1415 3966-0071 78.1 µM -0.848396903847799 0.20853376834299 no 2709 0.198108483190121 3836 2893185
SGTC_482 fipronil 114 µM -0.851757482953613 0.207614263338901 no 2710 0.197174354409072 3954 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2171 5739187 198.077 µM -0.852410553082627 0.207435851945978 no 2711 0.196993132482533 3834 2262761
SGTC_1882 5615643 20 µM -0.853870286908977 0.207037396958005 no 2712 0.196588432284231 3825 2253075
SGTC_1389 3405-0187 19 µM -0.854260521478953 0.206930953676178 no 2713 0.196480328078745 3880 799890
SGTC_2455 5377712 9.75 µM -0.85476218031442 0.206794165072782 no 2714 0.196341409649961 3908 2243908
SGTC_790 1575-0012 79.1 µM -0.85480914346194 0.206781362251462 no 2715 0.196328407751247 3996 378741 YLR208W SEC13
SGTC_2020 4017018 200 µM -0.855476831794018 0.206599391691273 no 2716 0.196143612549727 4000 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3329 9141233 27.5565 µM -0.855782862498976 0.206516018348794 no 2717 0.196058948108947 3903 4909101 YNL103W MET4
SGTC_92 0063-0024 660.874 µM -0.857178901745344 0.206135941915544 no 2718 0.195673010357488 3993 3594437
SGTC_1334 1486-0610 236 µM -0.857628183349705 0.20601371173942 no 2719 0.195548903751801 3997 3742339
SGTC_801 0866-0028 10.1 µM -0.858138258524836 0.205874994365607 no 2720 0.19540806188195 3906 6849771
SGTC_1673 st016611 27.3 µM -0.861904081932304 0.204852576653979 no 2721 0.194370151291993 3965 5226799
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.863053454209411 0.204541125524198 no 2722 0.194054038885733 3948 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_221 trifluoperazine 10.304 µM -0.865406222229579 0.203904463689232 no 2723 0.193407933519126 3895 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_325 2810-4341 181 µM -0.865623854368647 0.203845631905092 no 2724 0.193348234861934 3933 774970
SGTC_3336 9143619 71.43 µM -0.866569720611504 0.203590056540336 no 2725 0.19308890501245 3931 45595730
SGTC_1727 st034309 9.9045 µM -0.86824708738654 0.20313729815127 no 2726 0.192629540878803 4045 870305
SGTC_257 daunorubicin 18.5 µM -0.868259055669996 0.203134069808126 no 2727 0.192626265642978 3964 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_276 colchicine 750 µM -0.871485339316483 0.202264924545357 no 2728 0.191744603679452 4004 2833 A microtubule depolymerizer.
SGTC_1484 3473-2379 286 µM -0.872636470083024 0.20195535469904 no 2729 0.191430627740218 4035 671917
SGTC_2976 9009005 19.48 µM -0.873660213882292 0.201680281029542 no 2730 0.191151661988348 3952 2993148
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.878811237782003 0.200299641233264 no 2731 0.189751816035544 3883 279621
SGTC_455 paf C-16 10 µM -0.87973103636314 0.200053704588829 no 2732 0.189502515957126 3915 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1970 st070122 35.8 µM -0.879739416649021 0.200051464694637 no 2733 0.189500245510733 3959 102928
SGTC_1442 4112-3290 3 µM -0.880468085896049 0.19985676264158 no 2734 0.189302893285704 3920 704353
SGTC_424 splitomicin 100 mM -0.880868009169598 0.19974995070584 no 2735 0.189194632167206 4045 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.882304546896587 0.199366561988046 no 2736 0.188806069133319 3743 88881 An O-methylated flavonoid and antioxidant.
SGTC_891 0929-0073 133 µM -0.883640623903376 0.199010382576388 no 2737 0.188445121044622 4017 5603632
SGTC_1276 0871-0068 94.2 µM -0.884633865539324 0.198745846917648 no 2738 0.188177067675866 3956 3414906
SGTC_2340 7987427 183.45 µM -0.884870071101553 0.198682968174117 no 2739 0.188113355805329 3974 2239331
SGTC_1333 1482-0047 286 µM -0.884979302763135 0.198653894382204 no 2740 0.188083897184986 3935 3811116
SGTC_1328 1441-0025 69.2 µM -0.8860872716209 0.198359135385991 no 2741 0.187785250680539 3905 4562601
SGTC_3077 9117319 49.47 µM -0.886189918991054 0.198331840911234 no 2742 0.187757597515614 3906 17154678
SGTC_3176 9106582 49.47 µM -0.886852654708747 0.198155670568542 no 2743 0.187579117299367 3877 17018027
SGTC_2557 derrustone 83.84 µM -0.88700531449681 0.198115103489627 no 2744 0.187538019614411 3936 629853 An antioxidant.
SGTC_3086 9117350 49.47 µM -0.887903078533147 0.197876637456987 no 2745 0.187296444308016 3894 2679265
SGTC_1373 2887-0003 58.5 µM -0.888513836603095 0.197714505726395 no 2746 0.18713220817057 3943 776948
SGTC_2714 st079313 56.9 µM -0.888701925703063 0.197664591799888 no 2747 0.187081647942039 3931 2939799
SGTC_483 fpl-64176 144 µM -0.889933381679427 0.197337983802924 no 2748 0.186750829081008 3994 3423
SGTC_1451 4152-0210 104 µM -0.890134786359769 0.19728459812485 no 2749 0.186696758116026 3933 659563
SGTC_3209 9113616 49.47 µM -0.892519371124168 0.196653188326161 no 2750 0.186057307290651 3987 16649353
SGTC_2792 7535235 81.82 µM -0.893037770375106 0.196516084506765 no 2751 0.185918473096066 3966 1281891
SGTC_3094 9117742 49.47 µM -0.893271005237122 0.196454418533067 no 2752 0.185856030665365 3896 17149698
SGTC_1561 5-methoxyflavone 52.9 µM -0.894858288365172 0.196035061433557 no 2753 0.185431423358226 3888 94525
SGTC_1200 1643-0193 18.4 µM -0.900842360894286 0.194458969772867 no 2754 0.183836070505698 3953 5403974
SGTC_194 1486-1323 56.904 µM -0.901735466397955 0.194224405917163 no 2755 0.183598704013636 4008 5178754
SGTC_1032 k061-1018 98.7 µM -0.902823818341036 0.193938795891515 no 2756 0.183309703913874 4088 4005393
SGTC_2404 5161160 200 µM -0.904230642209207 0.193569990560094 no 2757 0.182936557605469 3940 2831543
SGTC_3168 9103419 49.47 µM -0.906031147255628 0.193098604431892 no 2758 0.182459683293162 3964 16649256
SGTC_996 3970-0799 1.8 µM -0.907243062243828 0.192781710711807 no 2759 0.182139138169321 4007 6615648 YGL040C HEM2
SGTC_2516 gossypol 71.55 µM -0.907425524981622 0.192734027559851 no 2760 0.182090908244174 4005 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2364 9055074 200 µM -0.907716636896624 0.192657965942591 no 2761 0.182013975882687 4005 6470630
SGTC_3224 9130643 49.47 µM -0.910102280622777 0.192035337173062 no 2762 0.181384285969769 4008 17644395
SGTC_2786 7743617 45.45 µM -0.910735359490133 0.191870316991807 no 2763 0.181217414269157 3932 583674
SGTC_1159 4092-0538 61.2 µM -0.911616284826543 0.191640836919588 no 2764 0.180985373370017 4017 717301
SGTC_1454 4239-0054 42.6 µM -0.913302670949375 0.191202004380065 no 2765 0.180541689001905 4107 1340767
SGTC_926 2268-1401 59.4 µM -0.915458379077744 0.190641942462038 no 2766 0.179975521423553 3957 2931578
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.915646390150777 0.190593144192582 no 2767 0.179926195772934 4027 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2648 atorvastatin 78.68 µM -0.915994260502019 0.19050287467275 no 2768 0.179834952625931 4004 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_147 4466-0538 29.23 µM -0.916095028903414 0.19047673099841 no 2769 0.179808527444452 4068 6742687 YHR072W ERG7
SGTC_1234 0326-0494 15.5 µM -0.917803746603631 0.19003375131695 no 2770 0.179360810217695 4076 1547813
SGTC_2254 7938975 95.19 µM -0.918166998090467 0.189939661189754 no 2771 0.179265721693666 4073 2969277
SGTC_3056 9094900 49.47 µM -0.918401078800082 0.189879044312322 no 2772 0.179204463069172 3979 25236784
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.918440137353864 0.189868930977897 no 2773 0.179194242777135 4047 94937 An inhibitor of serotonin biosynthesis.
SGTC_1244 0416-0015 52.5 µM -0.918706093113574 0.189800076518545 no 2774 0.179124660968681 3967 96201
SGTC_1252 0493-0875 34.8 µM -0.919330420561984 0.18963850197263 no 2775 0.178961385433452 3978 3960963
SGTC_2534 helenine 20.12 µM -0.925166227227973 0.188132303197671 no 2776 0.177439724022385 3996 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_294 k038-0071 157 µM -0.925809198280036 0.187966807620682 no 2777 0.177272573052689 4000 24152826
SGTC_1614 st002383 48.6 µM -0.926079900120029 0.187897158038997 no 2778 0.177202229382324 3994 1947235
SGTC_1515 3460-0031 42.1 µM -0.926095763551955 0.187893076989616 no 2779 0.177198107711124 3925 2876596
SGTC_1081 sertraline 6 µM -0.927614542612357 0.187502607196124 no 2780 0.176803775686238 3996 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.928480909796409 0.187280093716107 no 2781 0.176579082918997 4046 6708760
SGTC_3217 9129673 49.47 µM -0.928625425552478 0.187242992895916 no 2782 0.17654162026609 4031 17248312
SGTC_918 glabranin 770.725 nM -0.929920788828668 0.186910643614394 no 2783 0.176206049231907 4024 124049 Also referred to as licorice root.
SGTC_1337 1486-1011 40.3 µM -0.930113758861388 0.186861164859776 no 2784 0.176156093846875 3996 X1337
SGTC_341 1486-1430 230 µM -0.932111275654463 0.186349465069577 no 2785 0.175639510693561 3988 2054753 YPL210C SRP72
SGTC_1964 st076914 61 µM -0.932501713868584 0.186249548828558 no 2786 0.175538650685138 4044 24208661
SGTC_3313 9133968 57.047 µM -0.933605524277678 0.18596725461013 no 2787 0.175253707328069 3995 1494643
SGTC_1193 1488-0126 41.5 µM -0.933756566077064 0.18592864703933 no 2788 0.175214739439567 3993 1384710
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.93407074965364 0.185848354963197 no 2789 0.175133699544918 4025 616764
SGTC_2508 celastrol 40.54 µM -0.939379408039168 0.184494938768803 no 2790 0.173767990785616 3956 122724 Celastrol is a natural product and antioxidant.
SGTC_1908 st060353 56.5 µM -0.939415037270996 0.184485876032153 no 2791 0.173758847732986 4081 4227716
SGTC_2692 st077426 47.7 µM -0.939536127975941 0.184455077180519 no 2792 0.173727776134376 4039 25238571
SGTC_3194 9111903 49.47 µM -0.942842425208257 0.183615372244189 no 2793 0.172880753879812 4067 17087251
SGTC_1701 st028638 40.4 µM -0.9436454993607 0.18341177449659 no 2794 0.172675416592394 4017 3490878
SGTC_1383 3049-0032 20.7 µM -0.944043918487397 0.183310818347022 no 2795 0.172573602901612 4093 712864
SGTC_625 k213-0058 121 µM -0.944392929296742 0.183222410338401 no 2796 0.172484446678726 4089 3655420
SGTC_2338 7999974 200 µM -0.9478869534871 0.182338804514087 no 2797 0.171593503695799 4044 315925
SGTC_3215 9129942 49.47 µM -0.948201387270474 0.182259417968402 no 2798 0.171513470531689 4015 17682944
SGTC_3024 9090631 49.47 µM -0.949735984742496 0.181872281108173 no 2799 0.17112321018737 3993 25236383
SGTC_2272 7805186 180 µM -0.949965618046481 0.181814395193128 no 2800 0.171064861497808 4044 2956062 YPR165W RHO1
SGTC_1738 st035555 74 µM -0.950211398496967 0.181752451678963 no 2801 0.171002423998863 4102 5331140
SGTC_1265 0819-1001 68.8 µM -0.952168093084124 0.181259781243603 no 2802 0.170505869929385 3993 3106768
SGTC_2187 6125751 200 µM -0.954473546124661 0.180680372278913 no 2803 0.169921996845529 4045 874498
SGTC_1319 1306-0155 43.7 µM -0.954535790417853 0.180664745092936 no 2804 0.169906250808106 4085 3122360
SGTC_2886 9058944 51.95 µM -0.955070293064933 0.180530586598702 no 2805 0.169771075336464 3885 4949929
SGTC_2384 9036245 200 µM -0.955134695377237 0.180514426038661 no 2806 0.169754792678427 3984 6462766
SGTC_1068 loratadine 26.9 µM -0.955778164107936 0.180353009380741 no 2807 0.169592161259946 4063 3957 A H1 histamine antagonist.
SGTC_811 0416-0114 265 µM -0.956067839995609 0.180280372618649 no 2808 0.169518980705003 4111 6612453
SGTC_254 nsc-64875 3.808 µM -0.956696194803151 0.18012287460684 no 2809 0.169360309658233 4048 56993
SGTC_3253 9135987 49.47 µM -0.95727284139737 0.179978413361973 no 2810 0.169214779786115 4044 4182430
SGTC_268 camptothecin 39.6153 µM -0.957544424818636 0.179910401614137 no 2811 0.16914626735712 4002 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_225 nsc-122657 1.016 µM -0.958450965478125 0.1796834964848 no 2812 0.168917703060937 4045 275685
SGTC_14 0354-0009 295 µM -0.959847172580924 0.179334380832775 no 2813 0.168566068443182 4113 1713507
SGTC_639 0833-0042 114 µM -0.960893468992793 0.179073038633779 no 2814 0.168302867477683 4047 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2417 cerulenin 830 nM -0.961575333273023 0.178902852717818 no 2815 0.1681314835358 4078 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1241 0364-0022 50.8 µM -0.962182813040099 0.178751318139674 no 2816 0.167978890472756 4066 4563895
SGTC_528 3492-0019 172 µM -0.963601092882913 0.178397845820234 no 2817 0.167622979350843 4041 2869262
SGTC_78 0336-0123 156.75 µM -0.964060097672038 0.178283544244226 no 2818 0.167507898215789 3872 6765896
SGTC_3200 9114385 49.47 µM -0.964395942479603 0.178199941265309 no 2819 0.167423727859168 4103 17018030 YLR208W SEC13
SGTC_1980 st071811 45.7 µM -0.96446983178624 0.17818155106815 no 2820 0.167405213174428 4148 4974850
SGTC_296 1222-0039 74.9 µM -0.965598159002486 0.177900872045329 no 2821 0.167122648451422 4043 5984176
SGTC_986 1493-0483 84 µM -0.967621536411721 0.177398242046366 no 2822 0.166616708729423 3983 40079
SGTC_1994 st072947 40.9 µM -0.967692576215352 0.177380611256778 no 2823 0.166598963411326 4111 5286565 YDL195W SEC31
SGTC_693 4161-2696 114 µM -0.968893910679374 0.177082629406924 no 2824 0.166299061988031 4083 805759
SGTC_3251 9135047 49.47 µM -0.970206432425869 0.176757430125862 no 2825 0.165971802545682 4066 17682963
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.970929527642906 0.17657843255127 no 2826 0.165791686512097 4018 2333 A French combination drug.
SGTC_2719 novobiocin 32.65 µM -0.971544221460857 0.176426359224751 no 2827 0.165638671624762 4062 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2810 7959871 45.46 µM -0.971778589981851 0.176368399009857 no 2828 0.165580354646368 4024 2974535
SGTC_3131 9127911 49.47 µM -0.973606633856591 0.175916730425547 no 2829 0.165125945609865 4121 45595681
SGTC_3152 9099253 49.47 µM -0.975980272186664 0.175331351832176 no 2830 0.164537120310345 3987 25236131
SGTC_972 1319-0219 195 µM -0.976482923017962 0.175207548440619 no 2831 0.164412603197765 4040 23903702
SGTC_3039 9090270 49.47 µM -0.978343402721904 0.174749792999665 no 2832 0.163952255138622 4079 17173750
SGTC_1703 st026983 48.3 µM -0.97918140359139 0.174543858127228 no 2833 0.163745177729038 4090 1104023
SGTC_3118 9124250 49.47 µM -0.981748533321949 0.173913957494241 no 2834 0.163111874465718 4005 1504786
SGTC_2980 9014342 25.29 µM -0.983111839237773 0.173580029410715 no 2835 0.162776199013158 4138 2996599
SGTC_903 1134-0042 114 µM -0.983542969044878 0.173474513466929 no 2836 0.162670139084823 4097 701009
SGTC_420 mitomycin C 81.9 mM -0.984637579469603 0.173206798826703 no 2837 0.162401061856182 4057 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1793 st048256 72.231 µM -0.985454365582123 0.173007204647514 no 2838 0.162200468261067 3942 672022
SGTC_1663 st014140 55.4 µM -0.986696425505312 0.17270396926258 no 2839 0.161895741463096 4147 4207120
SGTC_222 nsc-310342 10.666 µM -0.987079829170835 0.172610433915531 no 2840 0.161801752649599 4057 432556
SGTC_1094 duloxetine 25.4 µM -0.987462523079187 0.172517103937595 no 2841 0.161707973292916 4074 60834 A selective serotonin reuptake inhibitor.
SGTC_425 3825-7017 13.1 µM -0.989625738188315 0.171990152264374 no 2842 0.161178542431227 4150 3397440
SGTC_2203 7227154 166.4 µM -0.990372707996521 0.171808431943802 no 2843 0.160995990077359 4059 896304
SGTC_2431 5490079 200 µM -0.993358367120608 0.171083315894011 no 2844 0.16026767143206 4132 5722345
SGTC_1169 aniline yellow 25.8 µM -0.994709760783559 0.170755752319845 no 2845 0.159938722904414 4000 6051 A DNA damaging agent.
SGTC_379 3970-0972 5.9 µM -0.994987141570584 0.170688567824568 no 2846 0.159871259115667 4076 2898042 YBL034C STU1
SGTC_3185 9108267 49.47 µM -0.99549780102508 0.17056492507996 no 2847 0.15974710661962 4092 4910486
SGTC_2005 4024620 188 µM -0.997295847675505 0.170130031978554 no 2848 0.159310464325724 4067 236743
SGTC_1732 st034308 51.822 µM -0.997602824700314 0.170055854598193 no 2849 0.15923599541112 3955 830119
SGTC_3162 9099653 49.47 µM -1.00126266714416 0.169173093956449 no 2850 0.158349918338096 4077 25237511
SGTC_3087 9117406 49.47 µM -1.00136515068469 0.169148417163632 no 2851 0.158325152903859 4124 42546093
SGTC_3348 9149464 3.537 µM -1.00504989974001 0.168262710030426 no 2852 0.157436411326207 4047 1951442
SGTC_2333 9017922 200 µM -1.00777843051112 0.167608776164411 no 2853 0.156780421487444 4148 3163164
SGTC_216 k038-0035 28.382 µM -1.00793414806821 0.167571505527527 no 2854 0.156743038409088 4030 4444231 YPR107C YTH1
SGTC_678 1218-2179 85.9 µM -1.01002490492494 0.167071604823486 no 2855 0.156241679094182 4083 6820081 YOR116C RPO31
SGTC_1729 st035615 45.989 µM -1.0101332530174 0.16704572499052 no 2856 0.156215726262705 4140 17385451
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.01774799654828 0.165233357349034 no 2857 0.154398865700782 4147 368090
SGTC_1421 4029-0249 71.4 µM -1.01791554111597 0.165193624064992 no 2858 0.154359047659677 4172 2894095
SGTC_1753 st043925 64 µM -1.02031613925129 0.164625000100007 no 2859 0.153789275741877 4153 670181
SGTC_1682 st012968 530 nM -1.02349951881404 0.163872919008332 no 2860 0.153035863648388 4136 24207270
SGTC_661 1304-0007 33.6 µM -1.02406683401132 0.163739123879098 no 2861 0.152901854171023 4118 3117130
SGTC_2995 9067767 71.4286 µM -1.02415571771659 0.163718168049218 no 2862 0.152880865383933 4132 11673567
SGTC_1434 4073-0095 163 µM -1.02498127620882 0.163523611923402 no 2863 0.152686011243031 4049 24133745
SGTC_415 dibenzyl ketone 100 µM -1.02707091254116 0.163031826824612 no 2864 0.152193537064739 4097 7593
SGTC_3157 9099274 49.47 µM -1.02729679264906 0.162978724748202 no 2865 0.152140366098717 4154 17217662
SGTC_3242 9133940 49.47 µM -1.02739642473586 0.162955305849467 no 2866 0.152116917160649 4128 17248444
SGTC_2086 5274770 176.623 µM -1.0294021540262 0.162484316975344 no 2867 0.151645368671636 4152 689278
SGTC_2299 7976368 114.88 µM -1.03263698697803 0.161726576186861 no 2868 0.150886906151281 4153 2979718
SGTC_2941 9056145 11.23 µM -1.03313113483431 0.161611028024528 no 2869 0.150771267355629 4035 2119517
SGTC_2963 9082507 9 µM -1.03436425992548 0.161322917238083 no 2870 0.150482953036481 4174 16459611
SGTC_226 1,3-diallylurea 8.28947 mM -1.0364977338275 0.160825238149439 no 2871 0.149984998054203 4068 74537 YKL182W FAS1
SGTC_3150 9097574 49.47 µM -1.03860659207836 0.160334287365979 no 2872 0.149493869358793 4165 17217476
SGTC_158 k038-0087 26.446 µM -1.04014728217849 0.159976228262695 no 2873 0.149135739742333 4049 X158
SGTC_1721 st082152 9.2685 µM -1.04305670827194 0.159301499752252 no 2874 0.148461014701823 4063 5296051
SGTC_2927 9011802 47.9 µM -1.04383175196116 0.159122073233876 no 2875 0.148281619188622 4144 43912568
SGTC_1978 st071761 42 µM -1.04406411429861 0.159068305987187 no 2876 0.148227863699977 4152 5147680
SGTC_315 k915-0449 187 µM -1.04429850981422 0.159014080336063 no 2877 0.148173651060229 4150 20970215 YNL149C PGA2
SGTC_2009 4012297 12.05 µM -1.04443989814199 0.158981377060033 no 2878 0.148140956191295 4147 45595307
SGTC_2180 6301957 200 µM -1.05007706384796 0.157681085409475 no 2879 0.146841341490303 4160 845462
SGTC_2322 7413319 38.22 µM -1.05628956605684 0.156256199463848 no 2880 0.145417970718041 4182 1840400
SGTC_2206 7254556 146.969 µM -1.05644588595342 0.156220456017267 no 2881 0.145382275754294 4146 4398905
SGTC_2747 doxorubicin 7.63 µM -1.05908213285563 0.155618474418516 no 2882 0.144781188137973 4130 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2507 purpurin 79.67 µM -1.06195473693238 0.154964265362199 no 2883 0.144128116992229 4167 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2826 7992541 19.48 µM -1.06263322097147 0.154810012434425 no 2884 0.143974157708576 4167 2985066
SGTC_720 r052-1644 49.9 µM -1.06631757533829 0.153974148239785 no 2885 0.143140053630051 4187 1422863 YOR257W CDC31
SGTC_1188 1403-0014 4.57 µM -1.06632121216687 0.153973324635789 no 2886 0.143139231901382 4145 9614867
SGTC_822 1487-0950 154 µM -1.06909013511598 0.153347114364476 no 2887 0.142514528171421 4172 1958375
SGTC_2045 5106652 78.05 µM -1.06922091476031 0.153317579467498 no 2888 0.142485068316064 4126 673349
SGTC_2343 7990716 14.84 µM -1.07145790765686 0.152812967051093 no 2889 0.141981793660691 4158 6456862
SGTC_3199 9111318 49.47 µM -1.07303279507218 0.152458371300309 no 2890 0.14162820102571 4105 8548020
SGTC_544 k015-0020 52.4 µM -1.07354337586886 0.152343528146884 no 2891 0.141513693939884 4174 3008304
SGTC_2125 5246583 200 µM -1.07395076625295 0.152251936450033 no 2892 0.141422374199207 4184 835267
SGTC_2136 5328288 199.296 µM -1.07445942370747 0.152137628675475 no 2893 0.141308410725834 4150 262395
SGTC_1699 st031318 29.054 µM -1.07596862467344 0.151798809757813 no 2894 0.140970644333076 4205 5340658
SGTC_877 0771-0151 33.1 µM -1.07600219547784 0.151791278743782 no 2895 0.140963137257859 4189 6166523
SGTC_3012 9080433 71.4286 µM -1.0762564262883 0.151734254633791 no 2896 0.140906295178949 4178 17688859
SGTC_2953 9074162 66.49 µM -1.07830434610649 0.151275424381105 no 2897 0.140448979089452 4177 16451992
SGTC_2499 avocadenofuran 51.48 µM -1.07924042971692 0.151066005316109 no 2898 0.140240280440552 4142 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_988 1497-1057 103 µM -1.07937478707996 0.151035962949867 no 2899 0.140210342932365 4143 3533044
SGTC_1151 3909-8316 15.3 µM -1.08014250331611 0.150864377523577 no 2900 0.140039363668428 4213 800431
SGTC_1623 st003709 20.3 µM -1.08028336658988 0.150832908520599 no 2901 0.140008007180257 4131 16192618
SGTC_966 1300-0360 30.2 µM -1.08158687026386 0.150541911758085 no 2902 0.139718070612984 4157 70588
SGTC_554 4483-2211 187 µM -1.08410243854466 0.149981389107192 no 2903 0.139159690881616 4228 747107
SGTC_981 1488-1094 54.9 µM -1.08454697988354 0.149882480625688 no 2904 0.139061174338725 4148 3449522
SGTC_1860 st056228 74.6 µM -1.08606304580832 0.149545489889287 no 2905 0.138725550149466 4145 688679
SGTC_2682 pyrogallin 40.03 µM -1.08858565869482 0.148985885613885 no 2906 0.138168321925024 4176 822798 An ATP competetive kinase inhibitor.
SGTC_1615 st002656 86.5 µM -1.08925089780639 0.148838545587212 no 2907 0.138021629726467 4179 1584458
SGTC_616 4092-0450 108 µM -1.09200594907253 0.148229381929395 no 2908 0.137415243162204 4196 787165
SGTC_2900 5328528 85.29 µM -1.09210691328611 0.148207089671525 no 2909 0.137393055553301 4201 795359
SGTC_119 0121-0043 24.815 µM -1.09255227850347 0.148108782627958 no 2910 0.137295212553217 4191 1092378
SGTC_3000 9075062 71.4286 µM -1.09454567703654 0.14766930754839 no 2911 0.136857862862596 4141 17057871
SGTC_2052 5265182 7.135 µM -1.09590648221598 0.147369799428039 no 2912 0.136559851013824 4192 1239884
SGTC_1221 2958-7315 257 µM -1.09609656448681 0.147327995458732 no 2913 0.136518258974759 4230 4562705
SGTC_3264 9137442 49.47 µM -1.1003900608147 0.146385862494192 no 2914 0.13558110357838 4190 17015726
SGTC_1366 1683-0113 21.9 µM -1.10089599257256 0.146275111584559 no 2915 0.135470963199122 4203 708623
SGTC_2050 5263056 171 µM -1.10137750072768 0.146169759391937 no 2916 0.135366196750966 4191 763468 YGL055W OLE1
SGTC_1264 0783-0040 158 µM -1.10153448544233 0.146135422739811 no 2917 0.135332052055062 4077 2855798
SGTC_1859 st055998 20 µM -1.10188067682932 0.146059720802606 no 2918 0.13525677514606 4151 676301
SGTC_1344 1488-0097 29.1 µM -1.103404178146 0.145726888715777 no 2919 0.13492584153353 4233 747966
SGTC_2722 naftopidil 47.16 µM -1.10680734019455 0.144985258787687 no 2920 0.134188617005752 4134 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2857 9024691 58.44 µM -1.10683319932365 0.144979633212392 no 2921 0.134183025774028 4284 16478292
SGTC_338 4055-0136 114 µM -1.1069152561536 0.144961782970259 no 2922 0.134165284598404 4175 2900563
SGTC_2909 7941780 10.49 µM -1.10754112651271 0.144825682868335 no 2923 0.134030020710966 4180 1243215
SGTC_1177 0983-0204 23.6 µM -1.11013945172407 0.144261578309607 no 2924 0.133469469556033 4231 766818
SGTC_10 0279-0212 42.575 µM -1.11090304747814 0.144096081250824 no 2925 0.133305041803241 4182 39851 YBR002C RER2
SGTC_768 0384-0033 77.3 µM -1.112402111964 0.143771555706793 no 2926 0.13298264848792 4166 3965305 YMR134W ERG29
SGTC_2118 5526350 200 µM -1.1127926414841 0.14368709280788 no 2927 0.132898748239948 4243 743594
SGTC_1503 4585-0012 61.3 µM -1.11382717641046 0.143463507651295 no 2928 0.13267666788869 4244 2922052
SGTC_2794 7785382 27.27 µM -1.1153618308279 0.143132268815097 no 2929 0.132347699541731 4185 2205081
SGTC_1983 st071813 46.9 µM -1.1164407856349 0.142899697432636 no 2930 0.132116751745635 4272 11838595
SGTC_342 k048-0088 23.3 µM -1.11653730766991 0.14287890432149 no 2931 0.132096104975532 4200 6820570
SGTC_1278 0874-0585 172 µM -1.11928071635943 0.142288764686565 no 2932 0.131510199929477 4288 766306
SGTC_3160 9100216 49.47 µM -1.12176674637925 0.141755416557425 no 2933 0.130980814289741 4181 17191039
SGTC_2977 9011197 71.43 µM -1.12262037419401 0.141572593563501 no 2934 0.130799379271026 4293 2704722
SGTC_1050 3232-1156 69.3 µM -1.12400464861005 0.141276460750091 no 2935 0.130505526935054 4204 700529
SGTC_2234 tolnaftate 200 µM -1.12435335066594 0.141201930440554 no 2936 0.130431576867248 4274 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2954 9074818 52.69 µM -1.12610359233318 0.140828242890383 no 2937 0.130060836834298 4245 16648742
SGTC_1122 capsaicin 818.572 nM -1.12641366568146 0.140762110318435 no 2938 0.129995232543979 4274 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1492 4158-0558 28.5 µM -1.13476291188248 0.138989300836961 no 2939 0.128237334864056 4235 3967268
SGTC_548 1436-0017 110 µM -1.14157198357745 0.137554818716547 no 2940 0.126815987508272 4296 9677137
SGTC_664 1222-0054 14.9 µM -1.14203778848239 0.137457057246843 no 2941 0.126719156317781 4205 6813991
SGTC_2458 5808907 16.39 µM -1.1478511665557 0.136240956272288 no 2942 0.125515005260156 4384 2731747
SGTC_1640 st009078 66.4 µM -1.14842544421051 0.136121223898823 no 2943 0.125396487397897 4218 690618
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.15138169871471 0.135506007862142 no 2944 0.124787619791998 4262 551469
SGTC_324 1315-0088 19.6 µM -1.1522424923971 0.135327229739702 no 2945 0.124610720468794 4205 6787421
SGTC_1809 st050081 57.6 µM -1.1543460832673 0.134891015787349 no 2946 0.124179155194484 4321 5036894
SGTC_1597 7-benzyloxygramine 47.5 µM -1.15647334306881 0.134450875609222 no 2947 0.123743798501208 4168 260807
SGTC_2287 7945887 168.79 µM -1.15787875091065 0.134160631508659 no 2948 0.123456760070595 4258 1245853
SGTC_2245 6637752 200 µM -1.16371937464738 0.132959041725893 no 2949 0.122268877554408 4298 681890
SGTC_3114 9122766 49.47 µM -1.16380624575125 0.132941225856842 no 2950 0.122251270229859 4255 17176985
SGTC_1499 4480-0877 67.3 µM -1.16514164473065 0.132667563772495 no 2951 0.121980831086175 4224 2861909
SGTC_1897 st060201 15 µM -1.16614250573422 0.132462712816841 no 2952 0.121778416769376 4271 611878
SGTC_2261 9010538 184.68 µM -1.16616600043919 0.132457906664201 no 2953 0.121773668032455 4257 6457250
SGTC_214 4373-3496 70 µM -1.16785218659675 0.132113288730973 no 2954 0.121433196695184 4343 3779166
SGTC_534 k292-0788 63.4 µM -1.17219457794141 0.131228650983953 no 2955 0.120559472398762 4309 4146317
SGTC_2576 guaiol 23.12 µM -1.17300065464461 0.131064887213536 no 2956 0.120397771585614 4178 227829
SGTC_288 1315-0019 35.1 µM -1.17517813954278 0.130623212092734 no 2957 0.119961727061053 4313 6811474
SGTC_859 0439-0102 54.6 µM -1.17954348735046 0.129740859069631 no 2958 0.119090915437823 4277 610143
SGTC_3314 9135860 59.4275 µM -1.17983866367694 0.129681345418599 no 2959 0.11903219435374 4242 25252478
SGTC_2735 sertaconazole 140 nM -1.18101952287531 0.129443448921858 no 2960 0.118797483897299 4397 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_707 0865-0008 204 µM -1.18409115781186 0.128826052675939 no 2961 0.118188489962495 4300 723043
SGTC_258 haloperidol 50.781 µM -1.18417926632836 0.128808373121175 no 2962 0.118171053866088 4272 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1165 k072-0275 30.3 µM -1.18486483242236 0.128670867262353 no 2963 0.118035446981768 4248 6153523 YGL055W OLE1
SGTC_1550 gossypolone 36.6 µM -1.18513316004719 0.12861707580417 no 2964 0.117982401013045 4291 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2062 5245942 200 µM -1.18632740926782 0.128377854766871 no 2965 0.117746513196918 4315 1376160
SGTC_3125 9127534 49.47 µM -1.19300507257755 0.127045939749708 no 2966 0.116433693219039 4157 1639235
SGTC_2996 9066192 71.4286 µM -1.19458794636819 0.126731637553504 no 2967 0.116124030473731 4304 6472854
SGTC_2510 benzyl isothiocyanate 8.31 µM -1.19526793275515 0.126596782942783 no 2968 0.115991182175362 4284 2346 DNA damaging agent; causes G2/M arrest.
SGTC_319 1348-1596 45.5 µM -1.19689741512048 0.126274031517948 no 2969 0.115673270908419 4358 5380505
SGTC_2357 9067248 200 µM -1.19698350486351 0.126256995693393 no 2970 0.115656492069399 4258 9150235
SGTC_2210 7115885 190.385 µM -1.19771805293844 0.126111705163374 no 2971 0.115513399397051 4379 2927039
SGTC_2871 9038510 12.99 µM -1.1983977101627 0.125977375664524 no 2972 0.115381111746761 4272 4945164
SGTC_1222 0366-0074 1.18 µM -1.20283019225647 0.125103773582798 no 2973 0.114521019285592 4305 286520
SGTC_1743 st037606 46.3785 µM -1.20426591586438 0.124821714773146 no 2974 0.114243408021757 4254 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3165 9101544 49.47 µM -1.20580791017352 0.124519273517498 no 2975 0.113945782399881 4294 5002184
SGTC_833 3852-0053 558 µM -1.2062530102624 0.124432068541661 no 2976 0.11385997494317 4348 3123681
SGTC_3145 9085516 49.47 µM -1.20698591978335 0.124288568386582 no 2977 0.113718783253549 4291 25236195
SGTC_1799 st045822 46.1415 µM -1.20733607994539 0.124220049589224 no 2978 0.113651370563154 4277 3674992
SGTC_1972 st070201 17.4 µM -1.20887893423464 0.123918460973819 no 2979 0.113354680198263 4301 2829099
SGTC_3261 9137475 49.47 µM -1.2098445712033 0.123729964554019 no 2980 0.113169269841177 4244 17027690
SGTC_113 0099-0221 2.5 µM -1.2111117513365 0.123482910331013 no 2981 0.112926289108285 4261 89219
SGTC_1379 2144-0755 36.5 µM -1.21318658822297 0.123079138739306 no 2982 0.112529245322314 4350 5392327
SGTC_2739 tacrine 100.86 µM -1.21501409171954 0.122724266535904 no 2983 0.112180358415679 4353 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_15 0266-0086 27.098 µM -1.21592524510588 0.122547603357588 no 2984 0.112006700132171 4359 1712902 YIL048W NEO1
SGTC_754 3474-0146 171 µM -1.21987530636095 0.121783791281061 no 2985 0.111256074071743 4285 24762078
SGTC_545 4218-0007 221 µM -1.2222387795418 0.121328375838314 no 2986 0.11080867143928 4285 2840508
SGTC_638 3970-0837 4.09 µM -1.22508528187826 0.120781477298663 no 2987 0.110271545000256 4286 4118451 YLR208W SEC13
SGTC_3065 9113888 49.47 µM -1.22513057003242 0.120772790130449 no 2988 0.110263014378475 4350 16648368
SGTC_2453 5731132 22.18 µM -1.2265816767201 0.120494671801163 no 2989 0.109989929769412 4351 1362040
SGTC_1587 estradiol valerate 56.1 µM -1.22995541019101 0.119849807974189 no 2990 0.109356901446172 4362 13791 A steroid.
SGTC_3144 9087057 49.47 µM -1.23700349135277 0.118510480923402 no 2991 0.108042893230392 4229 17249618
SGTC_2240 6690706 185.951 µM -1.23705900646303 0.118499973699325 no 2992 0.108032588597885 4205 805876
SGTC_496 calpeptin 138 µM -1.23898415930144 0.118136011434802 no 2993 0.107675682231136 4314 73364 A calpain inhibitor.
SGTC_695 3505-6186 243 µM -1.23938086106997 0.118061110810788 no 2994 0.107602242902166 4314 1819379
SGTC_2414 st077232 92.9 µM -1.24136339537759 0.117687295075343 no 2995 0.107235767535997 4256 729801
SGTC_2260 7964312 200 µM -1.24238986456614 0.117494079201039 no 2996 0.107046376674744 4377 231951
SGTC_2304 7443016 91.4 µM -1.24275427302871 0.117425539375743 no 2997 0.106979198784099 4259 939854
SGTC_1646 st011709 75.6 µM -1.24321197357235 0.117339492812394 no 2998 0.106894865797837 4280 5757843
SGTC_3021 9087658 49.47 µM -1.24338918297869 0.117306189879447 no 2999 0.106862227204807 4319 25237042
SGTC_853 0419-0306 21 µM -1.24353257686443 0.117279246791962 no 3000 0.106835822049264 4336 762713
SGTC_613 3914-0030 117 µM -1.2436609831612 0.117255123527415 no 3001 0.106812180767249 4023 1145395
SGTC_77 0828-0286 12.516 µM -1.24617965049865 0.116782660298678 no 3002 0.106349224071146 4223 745345
SGTC_1195 1502-0147 41.1 µM -1.24647855705974 0.116726679741861 no 3003 0.106294378339161 4324 817940
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.24739096471715 0.116555917640186 no 3004 0.106127088943624 4314 229346 A bile salt which induces apoptosis.
SGTC_1262 0737-0114 49.6 µM -1.24809521138646 0.116424235213677 no 3005 0.105998095865014 4357 765919
SGTC_1706 st031321 9.9705 µM -1.24884623777124 0.116283922078341 no 3006 0.105860659269273 4335 6103185
SGTC_1391 3442-0225 151 µM -1.24928396999092 0.11620219659194 no 3007 0.105780614426907 4288 5227075
SGTC_998 3996-0085 177 µM -1.25056901918744 0.115962510821532 no 3008 0.105545879791194 4350 715391
SGTC_9 0092-0002 10.449 µM -1.25758362553852 0.114660342077377 no 3009 0.104271189135148 4334 759368
SGTC_2962 9082311 13.18 µM -1.25865806223568 0.114461809737609 no 3010 0.104076932670933 4303 16459453
SGTC_1504 k297-0033 30 µM -1.25962997860769 0.114282431808864 no 3011 0.103901437869416 4212 4388117
SGTC_776 4476-4378 112 µM -1.26312558987769 0.113638932964139 no 3012 0.103272024423013 4390 2892008
SGTC_2777 climbazole 1.536 µM -1.2631295810512 0.113638199717771 no 3013 0.103271307365252 4170 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1325 1431-0015 227 µM -1.26462167677887 0.113364312678907 no 3014 0.103003489361627 4342 1103340
SGTC_1476 4112-3294 3.34 µM -1.27128710547931 0.112146565502878 no 3015 0.101813263968146 4331 704369
SGTC_2738 aclarubicin 5.55 µM -1.27393776266838 0.111664908809534 no 3016 0.10134273697499 4353 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_993 3909-8757 62.7 µM -1.27419212896531 0.11161876529801 no 3017 0.101297667009658 4279 4288324 YLR208W SEC13
SGTC_1342 1486-1464 234 µM -1.27527857578341 0.111421831162866 no 3018 0.101105329010072 4378 3253938
SGTC_1217 1183-1422 255 µM -1.27714085265977 0.111084845348222 no 3019 0.100776262106156 4377 2849664
SGTC_81 0411-0046 9.971 µM -1.27839794219335 0.110857783416984 no 3020 0.100554574629774 4329 12925265
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.27881275761068 0.110782930352243 no 3021 0.100481500142488 4305 688761
SGTC_1725 st036284 20.55 µM -1.27972748658881 0.110617996335007 no 3022 0.100320497095697 4394 707914
SGTC_2388 9080168 200 µM -1.2815297840924 0.110293540738882 no 3023 0.100003822661881 4365 15943073
SGTC_706 4262-0057 46.9 µM -1.28309438322425 0.110012430272039 no 3024 0.0997295056769711 4352 883298
SGTC_2103 5378138 10 µM -1.28349143376951 0.109941174322424 no 3025 0.0996599794034686 4427 244142
SGTC_930 2810-3379 265 µM -1.28399074034895 0.109851614200043 no 3026 0.0995725976772192 4367 1015764
SGTC_868 0527-0199 213 µM -1.28463957091184 0.109735312356621 no 3027 0.0994591320012081 4310 2849450
SGTC_464 bw-b 70c 158 µM -1.29542032665521 0.107815801161188 no 3028 0.09758763486551 4376 5353454
SGTC_1448 4255-0083 152 µM -1.29545993093873 0.107808794498405 no 3029 0.0975808076549151 4394 5399660
SGTC_114 0364-0001 490.298 µM -1.2975725473699 0.107435512433074 no 3030 0.0972171303726159 4394 4003655
SGTC_2938 9059746 27.26 µM -1.29773194173277 0.107407386592498 no 3031 0.0971897317650135 4368 6471769
SGTC_3310 9130229 44.1445 µM -1.29861850673532 0.107251045129284 no 3032 0.097037441782874 4390 7761258
SGTC_3009 9080819 71.4286 µM -1.30617949603577 0.105924364307705 no 3033 0.0957457619241032 4380 17027216
SGTC_2183 6420625 130.508 µM -1.31306661540654 0.104726281447093 no 3034 0.0945802510432357 4386 2897619
SGTC_3205 9113483 49.47 µM -1.31312283209759 0.104716542542375 no 3035 0.0945707806891501 4387 17018033
SGTC_2264 7948757 110.76 µM -1.3141645735099 0.104536191325377 no 3036 0.0943954137388588 4324 2971411
SGTC_3178 9107506 49.47 µM -1.31458406860574 0.104463629931916 no 3037 0.0943248636188355 4378 8897194
SGTC_889 0919-1524 82.7 µM -1.31617322434985 0.10418907962049 no 3038 0.094057954231513 4389 3905452
SGTC_2150 5556613 200 µM -1.31690500444605 0.104062829752552 no 3039 0.0939352344058396 4409 743190
SGTC_1257 0669-0121 16 µM -1.31757889832386 0.103946664805195 no 3040 0.0938223266744648 4370 4307855
SGTC_88 0180-0332 8.668 µM -1.31815719704705 0.103847053426477 no 3041 0.0937255153535749 4471 3101745
SGTC_3302 9125395 16.351 µM -1.31896085904423 0.103708738443233 no 3042 0.0935910991059672 4319 17599668
SGTC_3322 9139058 2.11 µM -1.31918442434431 0.103670285305329 no 3043 0.0935537320786484 4420 4908926 YPR165W RHO1
SGTC_1773 st048542 73.5835 µM -1.32058261332157 0.103430032026032 no 3044 0.0933202866437862 4356 3237138
SGTC_1719 st032227 49.2 µM -1.32410101112394 0.102827248165078 no 3045 0.0927347499136978 4380 3125804
SGTC_1737 st035557 69.7 µM -1.32529594277866 0.102623110232817 no 3046 0.0925365070716237 4230 5716916
SGTC_1008 4106-0037 6 µM -1.32571247753991 0.102552020182266 no 3047 0.0924674764163548 4393 2905394
SGTC_2055 5235184 200 µM -1.32743587830958 0.102258267604865 no 3048 0.092182268956303 4415 2836034
SGTC_197 4544-0043 41.561 µM -1.32825529544131 0.102118813343532 no 3049 0.0920468913700633 4393 896523
SGTC_648 0375-0473 33.3 µM -1.32841320709519 0.102091954718985 no 3050 0.0920208193880921 4364 1713139
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.33307096076644 0.101302044316431 no 3051 0.0912542589974405 4508 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2537 larixol 68.93 µM -1.33466484190018 0.101032762584976 no 3052 0.0909930327067857 4369 6708759
SGTC_3116 9124943 49.47 µM -1.33653681171944 0.100717165259969 no 3053 0.0906869383739533 4355 41905195 YPL160W CDC60
SGTC_2978 9011784 42.97 µM -1.33748643987922 0.100557341620869 no 3054 0.0905319528141773 4378 2994934
SGTC_59 0330-0160 1.33 µM -1.33980387747428 0.100168090751159 no 3055 0.0901545573618064 4343 4293482
SGTC_938 3126-1755 342 µM -1.34157294443889 0.0998716887166071 no 3056 0.0898672517751735 4399 1777771
SGTC_618 k072-0232 33.2 µM -1.34253804040543 0.0997102600053597 no 3057 0.0897108023854854 4438 5872756 YGL099W LSG1
SGTC_3214 9129694 49.47 µM -1.34498143963791 0.0993024123961444 no 3058 0.0893156142180943 4424 17158655
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.34547067317373 0.0992208972173048 no 3059 0.0892366428895083 4436 23665772 A membrane-active detergent.
SGTC_1089 terbinafine 2.25 µM -1.35176182446403 0.0981770342543947 no 3060 0.0882257600852326 4413 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3014 9081533 49.47 µM -1.35255788472253 0.0980455230351435 no 3061 0.088098457318779 4432 21367265
SGTC_1569 carminic acid 40.6 µM -1.3535342195876 0.0978844062791113 no 3062 0.0879425127965614 4484 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2783 7738165 71.43 µM -1.3607400059626 0.0967012904832938 no 3063 0.0867979335684964 4387 17201110
SGTC_1806 st050005 60.3 µM -1.3608688820972 0.0966802263760902 no 3064 0.0867775644725811 4466 5194765
SGTC_149 3970-0822 46.1 µM -1.36335575957825 0.0962744194255861 no 3065 0.086385208359646 4401 3114250 YBL034C STU1
SGTC_117 lucigenin 22.078 µM -1.36476524136826 0.0960449777463321 no 3066 0.0861634233684219 4393 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1282 0886-0010 32.4 µM -1.36545116238507 0.0959334660410244 no 3067 0.0860556464233973 4434 2836211 YNL267W PIK1
SGTC_2770 toltrazuril 17.5 µM -1.36716098771227 0.0956559104913609 no 3068 0.0857874252474687 4357 68591 Kills coccidiodes.
SGTC_2934 9036370 36.88 µM -1.37121262135266 0.0950005695213706 no 3069 0.0851543424223368 4387 6462800
SGTC_490 phenamil 164 µM -1.37291262606388 0.0947265854430013 no 3070 0.084889755466518 4418 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1168 k815-0004 80.5 µM -1.37750500177869 0.0939893597559267 no 3071 0.0841780847247839 4405 642433
SGTC_2957 9076800 11.52 µM -1.38558436018514 0.0927026512608589 no 3072 0.0829369282950141 4402 16459615
SGTC_665 3914-0008 307 µM -1.38581919372579 0.0926654477767183 no 3073 0.0829010600025456 4387 1069549
SGTC_2303 7774051 200 µM -1.38971582425282 0.0920497353982371 no 3074 0.0823075938309209 4424 2953184
SGTC_2359 9039622 200 µM -1.39080556827334 0.0918780865712042 no 3075 0.0821421970673261 4390 6463596
SGTC_2284 7945075 39.21 µM -1.39230989318659 0.0916415255392837 no 3076 0.0819142884813089 4385 1245402
SGTC_2046 4110841 106 µM -1.39632527825943 0.0910123008525923 no 3077 0.0813082824937576 4432 44119630 YMR134W ERG29
SGTC_885 0865-0106 16.8 µM -1.40062189632783 0.0903425613360612 no 3078 0.0806635848024498 4407 2793380
SGTC_357 1325-0123 420 µM -1.4010788836365 0.090271543901735 no 3079 0.0805952426879449 4449 1098503
SGTC_849 0386-0493 241 µM -1.40187000173514 0.0901486994023648 no 3080 0.080477034964529 4454 726119
SGTC_1065 prochlorperazine maleate 2.48 µM -1.40268394903079 0.0900224396544242 no 3081 0.0803555528857463 4464 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2607 solasodine 47.35 µM -1.41045745668818 0.0888232242288202 no 3082 0.0792023250114949 4400 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1524 corynanthine 62.1 µM -1.41121118784172 0.0887075820870985 no 3083 0.0790911761394928 4519 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2564 betulinic acid 100 µM -1.4122471546679 0.0885488206042147 no 3084 0.0789386002228907 4467 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_951 1171-0579 82.7 µM -1.41339300490993 0.0883734661771225 no 3085 0.0787701006117138 4384 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3309 9129340 25.759 µM -1.41417079978357 0.0882545843821076 no 3086 0.0786558796664374 4440 17158987
SGTC_1688 st021091 57.6 µM -1.4196540315097 0.0874198817745773 no 3087 0.0778542135003378 4468 3656366
SGTC_70 0141-0289 43.283 µM -1.42143936183145 0.087149379759108 no 3088 0.0775945351179292 4402 352408
SGTC_2157 5649910 96.377 µM -1.42256567488913 0.0869790497325589 no 3089 0.0774310502007973 4431 2858091
SGTC_2940 9060638 45.86 µM -1.4290201097408 0.0860077516824485 no 3090 0.0764992267919679 4433 4027022
SGTC_3154 9100113 49.47 µM -1.432336601872 0.0855118355060218 no 3091 0.0760237564137315 4442 25237525
SGTC_2156 5649887 115 µM -1.43384954586058 0.0852863170377416 no 3092 0.0758076012757841 4479 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2757 clomiphene 4.22 µM -1.43417290963847 0.0852381744855621 no 3093 0.0757614628881272 4465 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3230 9131665 49.47 µM -1.44036966378638 0.0843195284042129 no 3094 0.0748814208247793 4466 15943720
SGTC_746 1095-0025 46.6 µM -1.44197103544348 0.084083343441483 no 3095 0.0746552724249439 4472 6749286
SGTC_261 5-fluorouridine 15.376 µM -1.44287215288616 0.0839506569487866 no 3096 0.0745282444837265 4483 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2899 9053889 58.44 µM -1.44822429194755 0.0831658111135541 no 3097 0.0737771664744958 4453 6470052
SGTC_2401 5128683 200 µM -1.453122039702 0.0824524442451171 no 3098 0.0730949363750537 4467 708373
SGTC_2514 salinomycin 42.74 µM -1.45365681489261 0.0823748329786324 no 3099 0.0730207383509506 4505 23682228 A polyether potassium ionophore.
SGTC_365 0121-0052 13.6 µM -1.45924520826142 0.0815670844720247 no 3100 0.0722488149956181 4459 3101739
SGTC_2077 5212015 200 µM -1.45933446425798 0.0815542320077489 no 3101 0.0722365370248671 4380 780900
SGTC_402 epigallocatechin gallate 10 µM -1.46259393575297 0.0810859281397747 no 3102 0.0717892618024537 4418 65064 An antioxidant.
SGTC_597 k018-0003 82.8 µM -1.46304608469548 0.081021126344022 no 3103 0.07172738459293 4525 6786234
SGTC_2728 chlorpromazine 9.18 µM -1.46392675617621 0.0808950210990281 no 3104 0.0716069809348568 4571 2726 A thorazine and dopamine antagonist.
SGTC_2877 9040724 71.43 µM -1.46428541729597 0.0808437061225729 no 3105 0.0715579899576321 4437 6463895
SGTC_3006 9075424 71.4286 µM -1.46714051587786 0.08043609271872 no 3106 0.0711689172412732 4434 7465181
SGTC_2217 6934799 96.0675 µM -1.46748982786352 0.080386329347774 no 3107 0.0711214272000573 4450 675606
SGTC_1820 st053765 18.6 µM -1.47096043512251 0.0798931658666563 no 3108 0.0706509085180253 4498 3690829
SGTC_1015 4130-4525 82 µM -1.47494234575391 0.0793301699738786 no 3109 0.070114022195924 4495 1363237
SGTC_190 3970-0790 3.722 µM -1.47625109787601 0.0791457848971583 no 3110 0.0699382483694514 4449 2832352
SGTC_573 3702-0553 84.7 µM -1.47653593294066 0.0791056986083851 no 3111 0.0699000381556505 4425 1222756
SGTC_2280 7785178 200 µM -1.48715494038113 0.0776221789388927 no 3112 0.0684869468972026 4469 2954328
SGTC_591 4299-0174 154 µM -1.48901008282754 0.0773651894159684 no 3113 0.068242356827853 4515 5509088
SGTC_1981 st071826 47 µM -1.49482296824387 0.0765641255247166 no 3114 0.0674803251788745 4530 11838600
SGTC_2567 aureobasidin a 60 nM -1.49503717877566 0.076534726521206 no 3115 0.0674523697104237 4567 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3080 9117754 49.47 µM -1.49582438997596 0.0764267606580998 no 3116 0.0673497118765453 4490 9550191
SGTC_698 k064-0052 127 µM -1.49628735221336 0.0763633196116107 no 3117 0.0672893947923739 4573 5088751
SGTC_1788 fluconazole 20 µM -1.49695795361661 0.0762714962411894 no 3118 0.0672020994827782 4494 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_260 nsc-65238 3.989 µM -1.49985694745637 0.0758755125499913 no 3119 0.0668257310782812 4483 3246252
SGTC_2381 9035592 200 µM -1.50486637177446 0.0751949506413434 no 3120 0.066179217769451 4511 4749657
SGTC_2844 9010103 25.97 µM -1.50508237886968 0.0751657097277902 no 3121 0.0661514493665103 4465 2480525
SGTC_721 1187-1332 279 µM -1.51300301952744 0.0740994687543324 no 3122 0.0651394459315198 4497 25730
SGTC_840 0245-0196 390 µM -1.51593185906548 0.0737081409907981 no 3123 0.0647682917060632 4561 3827528
SGTC_2497 7-hydroxyflavone 100 µM -1.5164032080273 0.0736453110196008 no 3124 0.0647087141933613 4514 5281894
SGTC_2316 5844804 197.44 µM -1.51761194176973 0.0734843761153653 no 3125 0.0645561273113945 4517 776813
SGTC_1670 st016595 4.04 µM -1.51923527535033 0.0732686632954117 no 3126 0.0643516425283112 4531 597879
SGTC_1632 st005650 90 µM -1.52352764488133 0.0727006159826563 no 3127 0.0638133748928935 4536 2759605
SGTC_2465 5809242 33.21 µM -1.52364143633716 0.0726856029686679 no 3128 0.0637991531216079 4583 2731748
SGTC_574 1315-0397 40 µM -1.52963969653568 0.071897582094247 no 3129 0.0630529689181239 4498 6794277
SGTC_2831 7999036 19.48 µM -1.53046628752941 0.0717895043575302 no 3130 0.062950676001206 4485 2988270
SGTC_2155 5570423 76 µM -1.53071485980085 0.0717570276255805 no 3131 0.0629199397938566 4495 797402
SGTC_1075 aripiprazole 15.2 µM -1.53165438904429 0.0716343770280784 no 3132 0.062803871671065 4556 60795 An atypical antipschotic. YIL048W NEO1
SGTC_919 tnp00227 403.569 nM -1.5336265008214 0.071377451410314 no 3133 0.0625607824515779 4475 1269246 A methoxyflavone. YNL221C POP1
SGTC_2833 9001315 45.46 µM -1.53612266744673 0.0710532671197083 no 3134 0.0622541489254711 4460 2989378
SGTC_200 k038-0079 37.545 µM -1.54660405957396 0.0697043496615559 no 3135 0.0609793751117137 4530 3436683
SGTC_2592 piperlongumine 83.33 µM -1.56034202771691 0.0679662813163531 no 3136 0.0593395383052616 4510 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2034 5197015 53.07 µM -1.56305636050555 0.0676268688399909 no 3137 0.0590196694213044 4528 780676
SGTC_1459 k035-0031 35.7 µM -1.56323395707521 0.0676047070865881 no 3138 0.0589987879006137 4278 3877128 YMR208W ERG12
SGTC_2669 eugenol 100 µM -1.56340508193301 0.0675833582278039 no 3139 0.0589786727969058 4552 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2971 9092186 9.93 µM -1.56446238375342 0.0674515689460927 no 3140 0.0588545101141717 4501 25236400
SGTC_846 0335-0850 148 µM -1.56477945899227 0.0674120852717127 no 3141 0.0588173148572403 4513 6819598
SGTC_2622 2-methoxyxanthone 59.94 µM -1.5660347705879 0.0672559434062587 no 3142 0.0586702386382942 4488 71034 A hepatoprotective.
SGTC_37 0566-0070 1.56 µM -1.57436803722778 0.0662264898775831 no 3143 0.0577011943705752 4454 1626686
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.57612877930127 0.0660105458006834 no 3144 0.0574980638936338 4564 16486 A toxic proline analog.
SGTC_536 3852-0578 10.6 µM -1.57758791375627 0.065832005750971 no 3145 0.0573301553956752 4559 2869208
SGTC_2170 morpholine 200 µM -1.58020412441761 0.0655128229960027 no 3146 0.0570300637809709 4568 121171 Reacts with secondary amines.
SGTC_2898 9056270 58.44 µM -1.58458644173944 0.0649808622315317 no 3147 0.056530163726848 4567 19154699
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.58812826638169 0.064553382180488 no 3148 0.0561286688629285 4543 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1051 3253-3903 78 µM -1.58820935862872 0.0645436204051197 no 3149 0.0561195027918769 4521 5509239
SGTC_1135 dihydrocapsaicin 536.708 nM -1.58936200701802 0.064404990104921 no 3150 0.0559893434900341 4448 107982 A Capsaicinoid.
SGTC_3351 9150312 21.596 µM -1.59158002201123 0.0641388780498557 no 3151 0.0557395509623612 4457 4904905
SGTC_2078 5212016 200 µM -1.59327941501713 0.0639355679442614 no 3152 0.0555487612463346 4451 1899708
SGTC_368 fentichlor 4.58 µM -1.59407653775862 0.0638403754911012 no 3153 0.0554594466048653 4534 7329 A pesticide.
SGTC_521 r062-0005 13.8 µM -1.59626833009642 0.0635791997371956 no 3154 0.0552144488280803 4482 2832033
SGTC_3025 9087895 49.47 µM -1.59664579396777 0.0635343048780855 no 3155 0.0551723424697029 4528 17173641
SGTC_2093 5331342 194.4 µM -1.59780686979718 0.0633963632977087 no 3156 0.0550429826437608 4579 33839
SGTC_1286 0929-0070 131 µM -1.59900060047284 0.0632547853229051 no 3157 0.0549102345882043 4594 1420408
SGTC_3328 9140624 29.0385 µM -1.59987440626985 0.0631513069857718 no 3158 0.0548132240607065 4526 4904392
SGTC_1540 guanosine 70.6 µM -1.60032995419496 0.0630974121269661 no 3159 0.054762702564552 4493 6802 Guanosine is a purine nucleoside
SGTC_2618 avocadyne 43.43 µM -1.60151070504984 0.0629578868751626 no 3160 0.0546319254524888 4489 3015189
SGTC_2849 9019321 12.99 µM -1.60458554934622 0.0625956709927101 no 3161 0.0542925218456761 4540 16489627
SGTC_2168 5727979 200 µM -1.61107748510964 0.0618362596416091 no 3162 0.053581417491303 4466 695210
SGTC_3213 9129884 49.47 µM -1.61413231038869 0.0614814106080846 no 3163 0.0532493651904615 4521 17190742
SGTC_2071 5230951 39.92 µM -1.61661718048926 0.0611939423601334 no 3164 0.0529804705153713 4586 1799272
SGTC_2925 9010536 32.5 µM -1.61883997501572 0.0609376839659346 no 3165 0.0527408493010245 4476 2994177
SGTC_560 2332-1943 155 µM -1.62178361845443 0.060599613472582 no 3166 0.0524248436007506 4549 21177716
SGTC_2642 cholecalciferol 100 µM -1.62867343672414 0.0598140704274601 no 3167 0.051691084468172 4559 9821465 A vitamin D precursor, similar to steriods.
SGTC_1078 idebenone 36.1 µM -1.63035374880033 0.0596237047492236 no 3168 0.0515133769216869 4579 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1871 st057448 67.3 µM -1.63035921114187 0.0596230866855168 no 3169 0.0515128000250158 4551 691747
SGTC_873 0591-4978 488 µM -1.63521204508071 0.0590759695382141 no 3170 0.0510023019951199 4579 3305145
SGTC_1549 4'-methoxyflavonol 74.6 µM -1.63643632361635 0.0589385661673433 no 3171 0.0508741511318242 4538 97141
SGTC_2703 st077852 53.4 µM -1.63731349191738 0.0588402739904446 no 3172 0.0507824916277882 4590 6281836
SGTC_758 0868-0029 16 µM -1.63750620880277 0.0588186961070375 no 3173 0.0507623713498895 4505 762687
SGTC_1287 0971-0001 34.6 µM -1.6437996635136 0.0581174452076631 no 3174 0.0501087954514606 4559 4665869
SGTC_1030 k029-0042 36.7 µM -1.64416845727597 0.0580765568433586 no 3175 0.0500707052427741 4551 6080581
SGTC_614 0462-0418 107 µM -1.64935779771705 0.0575036057021583 no 3176 0.0495371776050454 4333 5188303
SGTC_2367 9070478 135.38 µM -1.65004305323053 0.0574282806456327 no 3177 0.0494670653546568 4506 572802
SGTC_1046 2001-0062 216 µM -1.65659340046102 0.0567121612629564 no 3178 0.0488008537626771 4514 739778
SGTC_172 1112-0046 2.638 µM -1.66071521600179 0.0562651602012923 no 3179 0.0483853279819652 4563 2802135 YIL048W NEO1
SGTC_1182 1222-0449 220 µM -1.66504725429843 0.05579835952567 no 3180 0.0479516643055979 4582 658318
SGTC_2717 st081029 62.2815 µM -1.66590175631929 0.0557066441312661 no 3181 0.0478664918811817 4550 5292846
SGTC_2970 9090938 41.86 µM -1.66633654890319 0.0556600226715893 no 3182 0.0478232004784448 4604 17217104
SGTC_2030 5175110 200 µM -1.66764302698374 0.0555201183508174 no 3183 0.0476933057392015 4573 2831986
SGTC_1902 st060212 70.5 µM -1.67079589029892 0.0551836370017595 no 3184 0.0473810002896121 4567 688944
SGTC_285 1486-1325 46 µM -1.6777669075582 0.0544453915198326 no 3185 0.0466963059919385 4615 22310230
SGTC_2352 9027995 87.8 µM -1.68112748814731 0.054092300595231 no 3186 0.0463690770969503 4546 2997347
SGTC_892 0929-0076 29 µM -1.68593491205235 0.05359034575087 no 3187 0.0459041683090715 4565 5751038
SGTC_2681 menadione 3.18 µM -1.6879507618889 0.053380967104664 no 3188 0.045710340564066 4608 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2876 9059903 25.97 µM -1.69060925393022 0.0531058315230086 no 3189 0.0454557280391558 4573 6916095
SGTC_2281 7943571 200 µM -1.69247555172993 0.0529133552090332 no 3190 0.0452776688803593 4657 1244024
SGTC_1025 k007-0731 70 µM -1.69263883439925 0.0528965417850669 no 3191 0.0452621171888808 4565 6256118
SGTC_1841 st054148 70 µM -1.693078772122 0.0528512619287077 no 3192 0.0452202371549729 4601 675442
SGTC_1076 itraconazole 331 nM -1.69812701017299 0.0523338782899665 no 3193 0.0447418963611627 4598 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2197 6588183 93.1375 µM -1.69831431609773 0.0523147593396459 no 3194 0.0447242270729994 4613 884136
SGTC_953 1188-0045 9.7 µM -1.70002310353415 0.0521405936078743 no 3195 0.0445632899351427 4557 6144426
SGTC_2603 homopterocarpin 100 µM -1.70329377822061 0.0518085193638033 no 3196 0.0442565521827593 4571 101795 A weak amylase inhibitor.
SGTC_2623 humulene 100 µM -1.70731847779247 0.0514021976594899 no 3197 0.0438814367474757 4564 6187145 An anti-inflammatory.
SGTC_2153 5569715 200 µM -1.70788643202725 0.0513450633198529 no 3198 0.0438287086082898 4611 2054701
SGTC_2823 7987624 58.44 µM -1.71596065902189 0.0505382742102346 no 3199 0.0430846215709472 4526 2239440
SGTC_6 0844-0013 19.835 µM -1.7303460431835 0.0491259178403251 no 3200 0.0417842339200336 4678 1584900
SGTC_1578 josamycin 24.2 µM -1.73216347298286 0.0489497478657549 no 3201 0.0416222302795978 4593 5282165 A P450 substrate.
SGTC_1279 0874-0590 65.2 µM -1.73474257420105 0.0487006131570712 no 3202 0.0413932058718029 4671 3523074
SGTC_195 4234-0266 16.654 µM -1.74100563101186 0.0480998358457877 no 3203 0.040841295742534 4621 2303354
SGTC_1384 3089-0840 101 µM -1.74855945929193 0.0473831487730699 no 3204 0.0401835996015782 4602 1069836
SGTC_2606 farnesol 9.78 µM -1.74901703932874 0.0473400111517598 no 3205 0.0401440370450972 4586 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1096 rimcazole 32.2 µM -1.75062597987366 0.0471885807006094 no 3206 0.0400051785732609 4580 18528119 A dopamine reuptake inhibitor.
SGTC_800 3448-7362 155 µM -1.75450536221558 0.0468250570935044 no 3207 0.0396719759511271 4671 15991913
SGTC_290 2043-6722 48.1 µM -1.75875605420447 0.0464293220845414 no 3208 0.0393094759838163 4625 773758 YLR208W SEC13
SGTC_336 4111-0029 111 µM -1.76327719655749 0.0460113594597317 no 3209 0.0389268746845874 4635 3131175
SGTC_2800 7887935 81.82 µM -1.76977043070272 0.0454163780589705 no 3210 0.0383826958063248 4590 2961002
SGTC_3355 9151058 44.0485 µM -1.77139746528195 0.0452682649159907 no 3211 0.0382473149039977 4627 17015728
SGTC_620 0109-0052 432 µM -1.78007350992898 0.044485011011274 no 3212 0.037531965588038 4650 493037
SGTC_2270 7924575 90.91 µM -1.78639254944684 0.0439214434501931 no 3213 0.0370178605621347 4587 1262135
SGTC_1969 st069479 40.1 µM -1.78665369482172 0.0438982775120633 no 3214 0.036996738749425 4612 3895485
SGTC_3190 9110366 49.47 µM -1.7877969136592 0.0437969797236064 no 3215 0.0369043895030065 4620 17123768
SGTC_17 0960-0276 49.807 µM -1.78950599038905 0.043645894433203 no 3216 0.03676668180537 4617 6821114
SGTC_2266 7929956 200 µM -1.8030301498084 0.0424651148316799 no 3217 0.0356917399006103 4594 2967153
SGTC_1875 nocodazole 6 µM -1.80841669786411 0.0420020744267673 no 3218 0.0352708355206489 4646 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3226 9131256 49.47 µM -1.81303307258387 0.0416084999780001 no 3219 0.0349133602564945 4655 17178073
SGTC_3265 9137266 49.47 µM -1.81579268010008 0.0413746567095579 no 3220 0.0347010902891307 4618 17224265
SGTC_1824 st053723 68.6 µM -1.8218294793832 0.0408668242352436 no 3221 0.034240431631362 4638 675225
SGTC_150 3970-0969 77.2 µM -1.82183914520349 0.0408660151926415 no 3222 0.0342396980983549 4637 6615640
SGTC_2121 5257820 149.641 µM -1.82192572421182 0.0408587689886613 no 3223 0.0342331282480165 4637 791256
SGTC_3049 9092223 49.47 µM -1.82310268018829 0.040760367375082 no 3224 0.0341439203752351 4608 8623917
SGTC_1563 conessine 56.1 µM -1.82414250979176 0.0406735905455075 no 3225 0.0340652651532145 4674 441082 An anti-amoebic, histamine inhibitor.
SGTC_2152 5568786 200 µM -1.83330916754234 0.0399150758262884 no 3226 0.0333783034126448 4673 5399883
SGTC_2013 4024628 200 µM -1.83428896424755 0.0398346850461925 no 3227 0.0333055557220786 4625 5230760
SGTC_1238 0333-0287 48.8 µM -1.84034531592501 0.0393406875706916 no 3228 0.0328587781695678 4650 7226
SGTC_2468 5987765 72.9 µM -1.84343560343528 0.0390905498415483 no 3229 0.0326327179104384 4672 26772094
SGTC_1160 4092-0570 10.5 µM -1.85023718742107 0.0385445676994584 no 3230 0.0321396856636819 4647 4994975
SGTC_307 1501-1223 22.3 µM -1.85051811939986 0.0385221508307087 no 3231 0.032119454476852 4654 2830329
SGTC_8 0354-0001 70 µM -1.85120195845498 0.0384676285409147 no 3232 0.0320702520640684 4635 4993152
SGTC_946 3434-1334 87.4 µM -1.85226014493388 0.0383833836224067 no 3233 0.0319942379154378 4612 4047976
SGTC_831 k061-1017 217 µM -1.85680945829696 0.0380229128503139 no 3234 0.0316691337966745 4674 1240153
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.85699194120933 0.0380085113859227 no 3235 0.0316561503150709 4673 66535 A nucleotide analog.
SGTC_555 4296-0685 37 µM -1.88949485175476 0.0355135025349341 no 3236 0.0294127759835024 4638 2908540 YHR072W ERG7
SGTC_191 3914-0123 66.505 µM -1.9007692433341 0.0346800636222197 no 3237 0.0286661221607182 4705 3144412
SGTC_2211 7117706 200 µM -1.90117945384423 0.0346500450185075 no 3238 0.0286392556591589 4641 822771
SGTC_1034 k072-0165 12.7 µM -1.90556612902262 0.0343303669296493 no 3239 0.0283532600566861 4659 5835461
SGTC_2641 levomentholum 100 µM -1.91088385208308 0.0339460931503913 no 3240 0.0280097543357956 4671 16666
SGTC_2305 7443522 69.23 µM -1.92156964570725 0.0331846023859797 no 3241 0.027329965549142 4573 5415886
SGTC_2868 9035608 32.47 µM -1.92525722314237 0.0329251065890147 no 3242 0.0270985931855646 4650 6462614
SGTC_1294 1000-1494 117 µM -1.93089767596529 0.0325314238247716 no 3243 0.0267478538294678 4675 712797 YDL207W GLE1
SGTC_1845 st056753 3.01 µM -1.9350416552481 0.0322446703749985 no 3244 0.0264925921162325 4643 5375839
SGTC_1048 3161-0300 24.5 µM -1.94228260235752 0.0317486228738896 no 3245 0.0260514489948344 4672 2165101
SGTC_1520 flindersine 88 µM -1.94445838635805 0.0316008066827926 no 3246 0.025920099467984 4666 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_418 lividomycin a 100 µM -1.96050029943679 0.0305284358108475 no 3247 0.0249686715084053 4693 72394 An antibiotic.
SGTC_2471 5466956 24.79 µM -1.96379293724847 0.0303121000701826 no 3248 0.0247770547423388 4690 724419
SGTC_2763 lisinopril 49.32 µM -1.97986463800453 0.0292743005164062 no 3249 0.0238593704229183 4603 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2154 5570129 200 µM -1.98989786089021 0.0286415127518015 no 3250 0.0233010940320295 4704 673366
SGTC_2185 6113692 200 µM -2.00458429416003 0.0277357965639581 no 3251 0.022503753537694 4675 874150
SGTC_1605 st000082 49.1 µM -2.01057292191534 0.027373389419279 no 3252 0.022185293296119 4670 1114022
SGTC_1546 5-methoxyflavanone 78.7 µM -2.01119188982542 0.0273361582320374 no 3253 0.022152596047965 4712 147795
SGTC_3284 9108171 64.8615 µM -2.02232104183016 0.0266739094157861 no 3254 0.021571598099198 4654 8687505
SGTC_3104 9120930 49.47 µM -2.02272600600004 0.0266500666249752 no 3255 0.0215507020652173 4693 17014836
SGTC_2353 9059630 146.67 µM -2.02913260404793 0.0262752323155288 no 3256 0.0212223929186021 4711 4779114
SGTC_1401 3807-4679 7.6 µM -2.032213650466 0.0260965433187906 no 3257 0.0210660157882864 4632 3291456
SGTC_2427 5545055 42.75 µM -2.03396563401023 0.0259953889574624 no 3258 0.0209775302614788 4653 5372858
SGTC_2132 5317594 122.667 µM -2.04442428158654 0.025398337887244 no 3259 0.0204558252804764 4640 794577
SGTC_2372 9071633 200 µM -2.04587765251609 0.0253162857059171 no 3260 0.0203842047748645 4719 21321366
SGTC_1913 st060213 96.1 µM -2.0478840470679 0.0252033767751853 no 3261 0.0202856811830579 4677 688959
SGTC_1042 0350-0096 82 µM -2.04976952403327 0.0250976573299192 no 3262 0.0201934634502606 4683 3122515
SGTC_909 3448-9333 149 µM -2.05100161708775 0.0250287743866693 no 3263 0.0201333946336823 4638 3344074
SGTC_3151 9099821 49.47 µM -2.05327237216808 0.0249022379024453 no 3264 0.0200230843976123 4641 17174189
SGTC_850 0388-0143 75.9 µM -2.05361944797322 0.0248829446523439 no 3265 0.0200062691739771 4710 67273
SGTC_2821 7996764 71.43 µM -2.05533216694816 0.0247879214879513 no 3266 0.0199234662090302 4654 2987135
SGTC_2429 5902844 64.44 µM -2.05623321068438 0.0247380530898231 no 3267 0.0198800212797538 4692 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2090 5301565 104.445 µM -2.0591729290408 0.0245759387906291 no 3268 0.0197388377422854 4710 2056344
SGTC_2774 tamoxifen 10.92 µM -2.06158157379129 0.0244437765379196 no 3269 0.0196237949039465 4688 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_409 arachidonic acid 100 µM -2.06210753262951 0.0244149966965187 no 3270 0.0195987496842509 4700 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1439 4092-1168 46 µM -2.06646252173451 0.0241777880481187 no 3271 0.0193924138520361 4718 2886240
SGTC_870 0573-2213 57.6 µM -2.06759105728629 0.0241166354694956 no 3272 0.019339246854036 4699 3916321
SGTC_3124 9127567 49.47 µM -2.06859689838905 0.0240622409668639 no 3273 0.0192919646190622 4676 17592030
SGTC_1926 methyl fluorone black 53.6 µM -2.0694123698974 0.0240182170840825 no 3274 0.0192537033568655 4379 72721 Reacts with homocysteine.
SGTC_2605 digitonin 300 nM -2.06995302284218 0.0239890668272917 no 3275 0.0192283719287943 4680 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2729 fluphenazine 10.66 µM -2.07082434457347 0.0239421505463061 no 3276 0.019187607159524 4685 3372 An atypical antipsychotic.
SGTC_3048 9093155 49.47 µM -2.09783888226203 0.022525356469905 no 3277 0.0179596902381104 4716 25236002
SGTC_2480 5767542 37.17 µM -2.09912437726126 0.0224597383965823 no 3278 0.0179029690254091 4655 2867358
SGTC_2908 7930301 100 µM -2.10000349213467 0.0224149568665656 no 3279 0.0178642669667391 4660 2223178
SGTC_3350 9150499 3.57 µM -2.1049191129484 0.0221659439184449 no 3280 0.0176491748297025 4705 4910996 YPR165W RHO1
SGTC_624 k048-0052 28 µM -2.11284276637887 0.021769467521773 no 3281 0.0173071139450681 4713 6835531
SGTC_44 0929-0055 61.211 µM -2.11772014614211 0.021528408969984 no 3282 0.0170993878187036 4552 1379590
SGTC_36 0335-0881 14.2 µM -2.12209655877399 0.0213140342459323 no 3283 0.0169148151641275 4644 23828853
SGTC_1056 3448-1962 115 µM -2.13254769785479 0.0208093866035441 no 3284 0.0164809238618616 4672 715507
SGTC_2555 cholic acid 100 µM -2.1404959072 0.0204324017012636 no 3285 0.0161573556050902 4692 6708657 Influences liver metabolism.
SGTC_2906 7926292 26.41 µM -2.15827828203342 0.0196098956747361 no 3286 0.0154531011126901 4691 2966319
SGTC_1828 st055811 49 µM -2.16111725194812 0.0194812201909025 no 3287 0.0153431416216991 4721 5877589
SGTC_1220 1838-0075 193 µM -2.1617245541246 0.0194537877147489 no 3288 0.0153197069212302 4667 5529645
SGTC_941 3237-0776 460 µM -2.16721747154739 0.0192071542023317 no 3289 0.0151091378946244 4706 760008
SGTC_1609 st001574 46.4 µM -2.19591547719285 0.0179614005719489 no 3290 0.0140489968634675 4721 3960012
SGTC_1154 4088-0362 150 µM -2.2093935425004 0.0174005267115966 no 3291 0.0135736398988675 4744 6618304
SGTC_1240 0356-0016 42.1 µM -2.2150682133971 0.0171688949928607 no 3292 0.0133776914102107 4700 4305613
SGTC_2440 5628896 157.78 µM -2.21703795409468 0.017089111471046 no 3293 0.0133102490269856 4719 5522048
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.23764420937713 0.0162732887231453 no 3294 0.0126221330736265 4738 688664
SGTC_2107 5363541 170.161 µM -2.24415567738457 0.0160225295286336 no 3295 0.0124111933329334 4693 244052
SGTC_126 0417-1624 672.48 µM -2.24649689962885 0.0159331812208673 no 3296 0.0123360989533025 4754 41912 YDL195W SEC31
SGTC_229 benomyl 22.8748 µM -2.24752616607399 0.0158940365956574 no 3297 0.0123032101304393 4754 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2478 5763493 32.33 µM -2.24960108403796 0.015815374810718 no 3298 0.0122371397923689 4704 1365576 YLR208W SEC13
SGTC_343 4130-2827 29.8 µM -2.25853999624227 0.0154802996778718 no 3299 0.0119560069695827 4723 1118244
SGTC_1935 st074532 41.6 µM -2.27843882412899 0.0147562107782924 no 3300 0.0113502227347786 4719 2829742
SGTC_2442 5158906 48.48 µM -2.28067697616581 0.0146766200974968 no 3301 0.0112837842782508 4728 1893835
SGTC_1865 st057639 52.2 µM -2.28157453063684 0.014644806168281 no 3302 0.0112572359158236 4750 688818
SGTC_1741 st038134 10.228 µM -2.28368642364445 0.0145701838305678 no 3303 0.011194983254543 4725 1272587
SGTC_533 1222-0222 6.71 µM -2.28557773025504 0.0145036337422894 no 3304 0.0111394871167106 4749 3982874
SGTC_1867 st057372 64 µM -2.29243663862355 0.0142644772537197 no 3305 0.0109402299251847 4735 688837
SGTC_3257 9139206 32.98 µM -2.30708860357921 0.0137649479405249 no 3306 0.0105249405753705 4742 4910041
SGTC_2736 butenafine 14.65 µM -2.31028092810929 0.0136581365385807 no 3307 0.0104363030544525 4702 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2419 paclitaxel 166.5 µM -2.34153073529537 0.0126497732690122 no 3308 0.00960242230882486 4709 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1683 st010134 710 nM -2.35216083805208 0.0123217711009698 no 3309 0.00933235120959049 4712 3818134
SGTC_2791 5663188 71.43 µM -2.36841054189859 0.0118346147334479 no 3310 0.00893235004856497 4726 54690634
SGTC_2624 nerol 100 µM -2.37326003835638 0.0116925060473413 no 3311 0.00881592285104005 4688 637566 A natural product oil.
SGTC_82 0054-0107 293.755 µM -2.3826083175026 0.0114227413749726 no 3312 0.00859523693534645 4737 3104697
SGTC_2386 9075165 157.42 µM -2.38953322558207 0.0112264100914844 no 3313 0.00843489894315659 4746 16452277
SGTC_3062 9077494 49.47 µM -2.39455796461099 0.011085794097285 no 3314 0.00832020649675227 4699 16459633
SGTC_1184 1269-1718 139 µM -2.39963435066254 0.0109452907749029 no 3315 0.00820572806359308 4771 5403821
SGTC_2232 chlorophetanol 41.5365 µM -2.40645135531733 0.0107590499062332 no 3316 0.00805417456487874 4777 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1591 genipin 88.4 µM -2.41899779204603 0.0104234840128322 no 3317 0.00778166733858356 4750 442424 A DNA cross-linking agent.
SGTC_535 2293-4129 48.2 µM -2.43209999723147 0.0100828269676057 no 3318 0.00750578112663343 4745 396118 YIL048W NEO1
SGTC_1023 4482-3888 16 µM -2.44869606925754 0.00966530494381124 no 3319 0.00716871862520767 4739 3303168
SGTC_3337 9144342 33.5465 µM -2.470925718388 0.00912976963711864 no 3320 0.00673819041051651 4750 17682949
SGTC_364 0083-0097 67.7 µM -2.47927198381108 0.00893551201700568 no 3321 0.00658254371802766 4746 5207356
SGTC_2104 5389443 200 µM -2.48070126931295 0.00890261137880771 no 3322 0.00655621066233131 4761 2244536
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -2.50334796026098 0.00839529539444468 no 3323 0.00615122628731767 4762 5024745
SGTC_1153 4055-0057 267 µM -2.55872272140664 0.00726030337184801 no 3324 0.00525287496632968 4777 882706
SGTC_1903 st060211 78.3 µM -2.56642414252417 0.00711367932282048 no 3325 0.00513765488173736 4764 688960
SGTC_1887 st057648 70.8 µM -2.57515457712549 0.00695062919481228 no 3326 0.00500976485305748 4764 688672
SGTC_1846 st056244 14.8 µM -2.60890588006942 0.00635090263898367 no 3327 0.00454161108057503 4763 5393182
SGTC_1984 st072354 53.1 µM -2.6119461254883 0.00629919826737556 no 3328 0.0045014220024973 4734 5762938
SGTC_2644 guaiazulene 100 µM -2.62861945370202 0.00602221331539483 no 3329 0.00428661196924891 4782 3515 A coloring agent.
SGTC_1512 0259-0544 12.2 µM -2.64422504509456 0.00577280338266068 no 3330 0.00409390990995077 4758 18476
SGTC_2693 st077581 40.7 µM -2.66673463726968 0.00542919991250378 no 3331 0.00382960604574344 4742 25238761
SGTC_2227 7312221 64.1025 µM -2.69213424395241 0.00506341287032246 no 3332 0.0035498180749165 4786 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1626 st003712 1.76 µM -2.75283638421784 0.00427663400100631 no 3333 0.00295407076403454 4774 24207035
SGTC_2408 sulbentine 18.36 µM -2.75475607819633 0.00425364167626599 no 3334 0.00293679530913222 4696 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1777 st045864 34.765 µM -2.78343878465245 0.0039230279668888 no 3335 0.00268930055634278 4784 4691462
SGTC_824 1304-0008 100 µM -2.78598257855133 0.00389484841092822 no 3336 0.00266828698665927 4782 768245
SGTC_2813 7971799 71.43 µM -2.80681618215032 0.00367079879176216 no 3337 0.00250168917904034 4761 2234054
SGTC_2383 9036125 200 µM -2.80770888864329 0.00366146210565471 no 3338 0.00249476542526579 4779 79580
SGTC_1906 st060206 94.7 µM -2.85394955525509 0.00320602927377014 no 3339 0.00215896935316878 4784 5133468
SGTC_2224 6650123 117.647 µM -2.87910794054553 0.00298026233552868 no 3340 0.00199400906218214 4804 2908370
SGTC_1572 epiandrosterone 68.9 µM -2.88128244589279 0.00296143790084245 no 3341 0.00198030273972303 4781 441302 A steroid.
SGTC_1121 fusaric acid 630.51 nM -2.89487284086068 0.00284619574222666 no 3342 0.00189656076909078 4769 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1775 st081588 35.1725 µM -2.89723459399431 0.00282658651078218 no 3343 0.00188234063161632 4776 1426443 YGL099W LSG1
SGTC_1888 azatryptophan 97.5 µM -2.90677290554906 0.00274862558692396 no 3344 0.0018258910159876 4787 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3323 9138564 53.9225 µM -2.90678058291784 0.00274856362586558 no 3345 0.00182584620658006 4788 43912313 YNL103W MET4
SGTC_2064 5220758 200 µM -2.90949092848055 0.00272676809909126 no 3346 0.00181008946387055 4792 788518
SGTC_1932 st074806 40.9 µM -2.9168903113333 0.00266805733261439 no 3347 0.00176770039033368 4788 17251235
SGTC_2634 4'-methoxyflavone 100 µM -2.92350694636577 0.00261652678124219 no 3348 0.00173056251309279 4761 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2213 7173844 200 µM -3.11956254735428 0.00144372656465297 no 3349 0.000905599014575619 4788 892728
SGTC_847 0342-0274 5.54 µM -3.25421946058013 0.000941759156844173 yes 3350 0.000568522014725415 4804 18097
SGTC_1763 st044482 94.5 µM -3.35802528770126 0.000670406131759989 yes 3351 0.000392507155914452 4799 88505
SGTC_2123 5259487 200 µM -3.4419317851675 0.000505959851628925 yes 3352 0.000288787939292903 4798 2173474
SGTC_2639 lactacystin 53 µM -3.61299641201616 0.000279793029399939 yes 3353 0.000151339446781615 4801 3870 A proteasome inhibitor.
SGTC_177 1327-0068 8.361 µM -4.07128843253944 5.05477941485194e-05 yes 3354 2.33769073531059e-05 4806 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1627 st003713 25.6 µM -4.10062173925103 4.502491924537e-05 yes 3355 2.06020801153364e-05 4804 16195070 YER133W GLC7
SGTC_818 4072-2707 53.5 µM -4.32780950406248 1.79176862955164e-05 yes 3356 7.52998171293637e-06 4803 882871