SGTCid condition conc unit YKL133C|YKL133C.score YKL133C|YKL133C.strain.pval YKL133C|YKL133C.strain.significant YKL133C|YKL133C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_527 4476-4215 268 µM 6.62013587776218 3.15865529977594e-10 yes 1 1.7943442245239e-11 9 4418754
SGTC_1002 4049-0206 172 µM 6.53196289808943 5.31036579650882e-10 yes 2 3.24566193238792e-11 3 4662749
SGTC_1912 st060209 90.8 µM 6.34808822528661 1.53583692506484e-09 yes 3 1.09003527743009e-10 9 688787
SGTC_2566 crystal violet carbinol 226 nM 5.8849786065191 1.96082830522203e-08 yes 4 1.99052742166185e-09 10 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2834 9001755 58.44 µM 5.36819109446761 2.71112908680505e-07 yes 5 3.9765131867338e-08 11 2989575
SGTC_2969 9091408 28.7 µM 5.08177892086168 1.05438639769813e-06 yes 6 1.86958226760623e-07 9 4286311
SGTC_154 3389-1638 511.116 µM 4.77428299753992 4.19551079433056e-06 yes 7 9.01743142667557e-07 11 5238686
SGTC_540 1187-0821 17.3 µM 4.72392389427699 5.22056026077826e-06 yes 8 1.15668509937343e-06 7 847520
SGTC_1436 4092-1007 8.32 µM 4.71123763689969 5.51424480330221e-06 yes 9 1.23108463707966e-06 4 2881121
SGTC_532 1548-0774 215 µM 4.5458878063809 1.11151784536154e-05 yes 10 2.7352085985945e-06 8 5932993
SGTC_1144 3486-0183 12.5 µM 4.41436629933319 1.90965584037515e-05 yes 11 5.06531510613166e-06 16 6744069
SGTC_881 0833-0569 170 µM 4.20614241286266 4.36737154468782e-05 yes 12 1.2988328830268e-05 19 5418700
SGTC_770 0389-1121 67.2 µM 4.15418559334477 5.33846028138697e-05 yes 13 1.63224068961402e-05 23 6753108
SGTC_2056 5235370 200 µM 4.14723976908857 5.48275384950824e-05 yes 14 1.68253803626159e-05 32 5511916
SGTC_2089 5281248 129.67 µM 4.10958895493807 6.3311268789662e-05 yes 15 1.98182005406984e-05 18 2737878
SGTC_2401 5128683 200 µM 3.87168053849134 0.000152920144028998 yes 16 5.40437776185929e-05 43 708373
SGTC_3159 9100096 49.47 µM 3.8473683621961 0.000166899199164527 yes 17 5.96966949973341e-05 21 25236875
SGTC_1249 0481-0015 10.2 µM 3.78561174801711 0.000207968952337076 yes 18 7.66654554690411e-05 28 4227577
SGTC_994 3910-0338 138 µM 3.72513673292022 0.000257177737582903 yes 19 9.76046911091478e-05 55 3479481
SGTC_785 1270-0111 65.3 µM 3.65345786816886 0.000329502405478693 yes 20 0.000129366129590337 39 6741994
SGTC_2473 5854593 8.94 µM 3.62132026804036 0.000367718808464262 yes 21 0.000146551699454361 19 2872951
SGTC_1505 k297-0037 20.6 µM 3.62125402940734 0.000367801663271207 yes 22 0.000146589232445661 26 4089396
SGTC_2884 9058502 51.95 µM 3.40714359839213 0.000747662388766217 yes 23 0.000328232898429627 44 6471554
SGTC_2208 7283366 200 µM 3.2790729092688 0.00112252566954372 no 24 0.00052074362191569 20 898663
SGTC_2366 9070441 60.58 µM 3.22830866827847 0.00131384564892665 no 25 0.00062262264521825 66 6837235
SGTC_3202 9113761 49.47 µM 3.18892803260732 0.00148230663965059 no 26 0.000714007121517213 87 4798415
SGTC_1338 1486-1223 76 µM 3.16817542602131 0.00157880260205845 no 27 0.000766994640736195 47 3444526
SGTC_1780 st038448 24.544 µM 3.16096472297706 0.00161364912016242 no 28 0.000786237707983092 59 728868 YDL195W SEC31
SGTC_416 estradiol valerate 100 µM 3.14747557497751 0.00168072468931547 no 29 0.000823434321715904 38 13791 A steroid.
SGTC_2108 5365811 200 µM 3.1448806679163 0.00169391556399343 no 30 0.000830772947174265 50 780283
SGTC_2999 9069765 71.4286 µM 3.13069019950656 0.0017677326683912 no 31 0.000871980136907501 67 2097066
SGTC_1238 0333-0287 48.8 µM 3.12270110431764 0.00181056723354151 no 32 0.000895998165643735 56 7226
SGTC_1786 berberine 21.6 µM 3.12258563433359 0.00181119320254966 no 33 0.000896349724296856 81 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1207 2099-0101 141 µM 3.11365723591669 0.00186019471867295 no 34 0.000923920106999889 60 5837381
SGTC_2059 5238311 157 µM 3.08824515322789 0.00200633113182089 no 35 0.00100671150432785 58 703021
SGTC_3305 9127027 53.8275 µM 3.0717437138065 0.002106727696847 no 36 0.00106406178777984 51 41905295
SGTC_1402 3909-7673 35.9 µM 3.06299858802315 0.0021617617165417 no 37 0.00109565546913805 40 5328014
SGTC_334 1502-1024 68.5 µM 3.02110454227806 0.00244391685530284 no 38 0.00125927193765179 46 3296216
SGTC_1787 fluconazole 80 µM 2.99776311593728 0.00261519099359423 no 39 0.00135984489206242 89 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1252 0493-0875 34.8 µM 2.90995970597662 0.00336086213350061 no 40 0.00180737677849395 87 3960963
SGTC_2687 chenodiol 100 µM 2.90843909969098 0.00337531030484547 no 41 0.00181618958553937 74 5702181 A cholesterol synthesis inhibitor.
SGTC_2815 7968870 71.43 µM 2.89694051463 0.00348638469302991 no 42 0.00188410598876828 84 2977326 YHR190W ERG9
SGTC_1480 1070-0044 41.2 µM 2.86422113091585 0.00382063031202516 no 43 0.00209018032756848 72 3124987
SGTC_1025 k007-0731 70 µM 2.8521775261362 0.00395071735735894 no 44 0.00217104217964248 66 6256118
SGTC_899 1083-0020 478 µM 2.8257284916314 0.00425041993239072 no 45 0.0023586615089389 79 767123
SGTC_1934 st074720 32.6 µM 2.78812294282013 0.00471154132206114 no 46 0.00265072103390652 123 17250992
SGTC_2054 5233173 129 µM 2.75389631228194 0.00516948389035642 no 47 0.00294452110957335 150 6889
SGTC_1633 st005664 67.9 µM 2.75024473117508 0.0052206069125253 no 48 0.00297753850555748 115 2063822
SGTC_376 3970-0862 59.1 µM 2.7451775794597 0.00529229335878109 no 49 0.00302390811725926 79 3135186
SGTC_2400 5203494 178.7 µM 2.73254942327436 0.00547477100465431 no 50 0.00314231208619141 83 6777674
SGTC_654 1124-0271 80.9 µM 2.72269809633507 0.00562098340335509 no 51 0.00323756001413029 99 5403748
SGTC_3295 9122362 53.5725 µM 2.71235257090026 0.00577825367429649 no 52 0.0033403746125877 71 4730473
SGTC_2591 skatole 100 µM 2.71040589583678 0.00580827927457551 no 53 0.00336004573900864 91 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1709 st033179 39.1045 µM 2.68090667595305 0.0062805227955332 no 54 0.00367114945654252 81 573381
SGTC_2456 5770359 74.46 µM 2.67011901358426 0.00646152697897521 no 55 0.0037912182939467 85 3118787
SGTC_3117 9124945 49.47 µM 2.64899984954054 0.00682928876860598 no 56 0.00403651837911598 61 17592065
SGTC_3248 9135562 49.47 µM 2.6434111300491 0.00692965145877343 no 57 0.00410376541892769 67 17650701
SGTC_2846 9008642 19.48 µM 2.60653156622633 0.00762519484950578 no 58 0.00457321964551374 82 2992898
SGTC_1886 st057356 49.9 µM 2.59302871010281 0.00789482488577768 no 59 0.00475674142305663 93 24207747
SGTC_1908 st060353 56.5 µM 2.56997592728233 0.00837456455364356 no 60 0.00508527910526814 142 4227716
SGTC_578 3460-0051 92 µM 2.55991470530906 0.00859184348484756 no 61 0.00523489280912352 95 2876744
SGTC_2746 daunorubicin 9.88 µM 2.53821997379545 0.00907725101100276 no 62 0.00557089640073921 29 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1246 0422-0085 105 µM 2.53104444503844 0.00924300151270319 no 63 0.00568617186639519 138 264295
SGTC_1444 4112-3581 28 µM 2.53024919016618 0.00926153348464866 no 64 0.00569907716031805 94 2877249
SGTC_1019 4262-0212 3.4 µM 2.52945816511485 0.00927999913659221 no 65 0.00571193960023761 186 4677213
SGTC_3030 9087619 49.47 µM 2.52302453532435 0.00943138583768221 no 66 0.00581751413936457 108 25236973
SGTC_1936 st074407 74.3 µM 2.51659880604223 0.00958473811408514 no 67 0.00592468352782507 160 809813
SGTC_3123 9126162 49.47 µM 2.51321034832267 0.0096664791719252 no 68 0.00598189884497423 105 25239884
SGTC_349 k015-0014 24 µM 2.50855641853779 0.00977974029379989 no 69 0.00606128038342695 124 2196908
SGTC_2469 5655019 90.81 µM 2.50816939374902 0.00978921118538817 no 70 0.0060679236779929 115 2788239
SGTC_3326 9140064 16.379 µM 2.50661609669229 0.00982730259515256 no 71 0.00609465104155329 103 1868434
SGTC_2842 9000675 19.48 µM 2.4611635365993 0.0110007351547751 no 72 0.00692436125854439 135 2989072
SGTC_1782 st039423 80.636 µM 2.45350473798783 0.0112100192645012 no 73 0.00707358378546498 140 2068169
SGTC_217 ketoconazole 989 nM 2.44443331721724 0.0114623751291032 no 74 0.0072539948841925 121 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2570 licareol 100 µM 2.43489744244459 0.0117329575562243 no 75 0.0074480055048807 150 443158
SGTC_3234 9132280 49.47 µM 2.43479144006733 0.0117359962873433 no 76 0.00745018760825739 130 17612295
SGTC_2421 5690543 90.72 µM 2.43235048888648 0.0118061593401605 no 77 0.00750059167896226 122 3397993
SGTC_2854 9024559 71.43 µM 2.42514607410626 0.0120153706281994 no 78 0.00765111412779573 137 3163529
SGTC_2903 5923464 63.88 µM 2.41151517381703 0.0124200093680652 no 79 0.00794319539376718 84 2876576
SGTC_1866 st057638 64 µM 2.40539551677819 0.0126054791438932 no 80 0.00807748540405732 108 688802
SGTC_2525 harmine 47.85 µM 2.39676868667522 0.0128710036879365 no 81 0.0082701808647558 84 5280953 A monoamine oxidase inhibitor
SGTC_2452 5863136 48.41 µM 2.38628713581834 0.0132001119100591 no 82 0.00850972845997592 130 2184096
SGTC_348 k064-0012 10.7 µM 2.38585954471116 0.0132136907324567 no 83 0.00851962866921188 118 5066323
SGTC_2524 avocatin b 10.57 µM 2.38253620377056 0.0133196406234678 no 84 0.00859692061330861 99 6710748
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.37688855501896 0.0135013739850122 no 85 0.00872968111250371 166 65057 A dermal irritant. YDR527W RBA50
SGTC_1781 st038725 66.3 µM 2.35631952052333 0.0141814657604503 no 86 0.00922851705917637 245 4270275 YIL048W NEO1
SGTC_1164 k060-0068 93.7 µM 2.35187877736007 0.0143321074060395 no 87 0.00933943058129593 158 5963676
SGTC_277 nystatin 15.5 µM 2.3512468078333 0.0143536570832177 no 88 0.00935530928678621 136 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1273 0849-0096 14.1 µM 2.34786235205761 0.0144695398755483 no 89 0.00944074879842303 134 5286025
SGTC_3195 9113082 49.47 µM 2.34019247264991 0.0147351385188116 no 90 0.00963690207950887 116 17018038
SGTC_1995 st072814 61.1 µM 2.32377824967813 0.0153176640291409 no 91 0.0100686910258768 139 5769371
SGTC_16 erodoxin 22.806 µM 2.32012631994016 0.0154499241591099 no 92 0.0101670224550186 217 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2082 5219693 150 µM 2.31958899783076 0.0154694665851552 no 93 0.0101815607977657 159 2834649
SGTC_13 0199-0087 65 µM 2.29918830669693 0.0162273000939012 no 94 0.01074712436197 119 4589825
SGTC_1406 3909-7906 11.9 µM 2.29604510671594 0.0163468445353412 no 95 0.0108366512159735 135 X1406
SGTC_2807 7945238 51.95 µM 2.26001473813955 0.0177719200773864 no 96 0.0119101680732164 182 17148797
SGTC_286 k060-0067 22.9 µM 2.2588231262708 0.0178208071147762 no 97 0.0119471946866173 151 5985051
SGTC_2029 5175081 200 µM 2.25312987259983 0.0180559647141904 no 98 0.0121254807206106 174 1380876
SGTC_2477 5967686 25.23 µM 2.24807129614782 0.018267121691251 no 99 0.012285822024897 153 776118
SGTC_183 3914-0051 30.55 µM 2.24259285023976 0.0184981746783194 no 100 0.0124615408631573 145 1596232
SGTC_2269 7935389 174.42 µM 2.23695889775687 0.0187383770867869 no 101 0.0126445132610911 159 97605
SGTC_415 dibenzyl ketone 100 µM 2.23604610779331 0.0187775424968832 no 102 0.0126743755273843 139 7593
SGTC_2782 7736369 71.43 µM 2.23515341162548 0.0188159130886022 no 103 0.0127036394293643 208 2950836 YOL077C BRX1
SGTC_2921 7974240 10.71 µM 2.23158679729736 0.01896988262331 no 104 0.0128211425187741 203 2979074 YDR527W RBA50
SGTC_121 0557-0495 61.343 µM 2.22629402216879 0.0192003442657157 no 105 0.0129972468146537 273 3104427
SGTC_2705 st078069 42.8 µM 2.21433177213622 0.0197299937851004 no 106 0.0134029822686611 140 1530061
SGTC_2694 st077685 81.9 µM 2.21214405408924 0.0198281884448179 no 107 0.0134783565036874 189 2838096
SGTC_1240 0356-0016 42.1 µM 2.20706152369426 0.020057917519503 no 108 0.0136548806951276 184 4305613
SGTC_651 3253-0966 34.4 µM 2.20400164947079 0.0201973088043484 no 109 0.0137621140423726 181 781462
SGTC_7 0192-1582 4.227 µM 2.20185782569111 0.0202954583975672 no 110 0.013837676443264 253 252616
SGTC_10 0279-0212 42.575 µM 2.19982737148988 0.0203887901760123 no 111 0.0139095726026064 325 39851 YBR002C RER2
SGTC_2926 9010726 65.15 µM 2.19828075374461 0.0204601257848582 no 112 0.0139645525315199 184 2994293
SGTC_337 1315-0038 354 µM 2.19678670893555 0.0205292372600489 no 113 0.0140178413716414 153 1626437
SGTC_3153 9100258 49.47 µM 2.18741551783207 0.0209672554169603 no 114 0.014356102183673 185 25236848
SGTC_1615 st002656 86.5 µM 2.18149502277144 0.0212480418373183 no 115 0.0145734110983385 157 1584458
SGTC_2718 lomofungin 53.02 µM 2.18037185656342 0.0213016666322782 no 116 0.0146149542745682 127 5351222 A RNA synthesis inhibitor.
SGTC_2128 5255449 168.493 µM 2.17674819905593 0.0214754565377328 no 117 0.0147496799631631 208 736008
SGTC_600 1495-0418 41.6 µM 2.15478892526273 0.0225544498055895 no 118 0.0155891776387102 159 5377768
SGTC_333 3486-0131 40.1 µM 2.14427260343564 0.0230871546878831 no 119 0.016005525320811 156 6744690
SGTC_2860 9025725 38.96 µM 2.13803291583354 0.0234082059382615 no 120 0.0162570359138374 147 40546248
SGTC_2462 5162487 171.77 µM 2.13734425441611 0.0234438687929383 no 121 0.0162850009503107 174 2259986
SGTC_147 4466-0538 29.23 µM 2.13570794413996 0.0235287897559395 no 122 0.0163516132428093 209 6742687 YHR072W ERG7
SGTC_403 arphamenine a 50 µM 2.11457538506203 0.0246489713388594 no 123 0.0172330767128418 197 5487158 An arginine aminopeptidase inhibitor.
SGTC_1174 0739-0097 51.1 µM 2.10665076935289 0.0250804144560681 no 124 0.0175739312579047 211 728447
SGTC_2958 9077254 16.72 µM 2.10187366003877 0.0253435417219859 no 125 0.0177821722216514 207 16457351
SGTC_1727 st034309 9.9045 µM 2.09059779905974 0.0259738086218502 no 126 0.0182820666108064 273 870305
SGTC_580 1123-0028 41 µM 2.08827681048687 0.0261051550240814 no 127 0.018386436016112 263 1677248 YPR107C YTH1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.08273205792064 0.0264211864809768 no 128 0.0186378268061266 214 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2601 securinine 100 µM 2.07696111948708 0.0267534990062275 no 129 0.0189025739382246 206 442872 A GABA receptor antagonist.
SGTC_1812 st052057 4.327 µM 2.06909098344534 0.027212310684711 no 130 0.0192687748415914 209 3645418
SGTC_2862 9027634 71.43 µM 2.06704499034236 0.0273326568951238 no 131 0.0193649573979767 201 5012562
SGTC_576 1073-0113 22.7 µM 2.05804726140735 0.027867187974539 no 132 0.0197927984132763 328 5439563
SGTC_88 0180-0332 8.668 µM 2.0571330234064 0.0279219845051581 no 133 0.0198367159589909 204 3101745
SGTC_1645 Cervolide 78 µM 2.05044150886059 0.0283257911153293 no 134 0.0201606830437419 153 23173 A fragrance.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.04865482045727 0.0284344291075843 no 135 0.0202479399911399 270 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 2.04856546429799 0.0284398714190794 no 136 0.0202523122941882 182 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1440 4100-1550 40 µM 2.04526868767688 0.0286412710306744 no 137 0.0204141879756097 127 742806
SGTC_864 0469-0573 172 µM 2.04478802710094 0.0286707333540357 no 138 0.0204378803292256 189 689425
SGTC_2912 7964298 10.93 µM 2.03746920577259 0.0291224662498879 no 139 0.0208015224110558 310 2975850
SGTC_2476 5806916 10.51 µM 2.01877154975381 0.0303034334443625 no 140 0.0217554846900371 179 2870194
SGTC_2727 riluzole 51.77 µM 2.00944661274393 0.0309070803734096 no 141 0.0222448955470756 165 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3272 9137413 49.47 µM 2.00620381840726 0.0311193201156405 no 142 0.0224172533272277 211 17614870
SGTC_673 1082-0474 110 µM 2.00413100273032 0.031255615799853 no 143 0.0225280145820854 309 3098046
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.99764923788988 0.0316850061630067 no 144 0.0228773505759046 284 688664
SGTC_2620 irigenin 100 µM 1.99329041068162 0.0319764928299501 no 145 0.0231148279207486 250 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_40 0327-0103 19.753 µM 1.99164037203412 0.0320874116609889 no 146 0.0232052652055791 252 409036
SGTC_2739 tacrine 100.86 µM 1.97492403672072 0.0332291266064415 no 147 0.024138384591496 200 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_756 0508-1999 28.3 µM 1.97046754234812 0.0335390888620616 no 148 0.0243924056678582 222 6753853
SGTC_2522 biochanin a 4.94 µM 1.96407948469739 0.0339875443255115 no 149 0.0247604374660507 203 5280373 A possible chelator.
SGTC_728 3030-5151 22.5 µM 1.95200554796455 0.0348486283208263 no 150 0.0254687729663001 199 3125388
SGTC_2827 7993847 71.43 µM 1.94796117668918 0.035141036888554 no 151 0.0257098043637683 193 2985692
SGTC_2153 5569715 200 µM 1.94629579877502 0.0352620276462906 no 152 0.0258096089830492 194 2054701
SGTC_2285 7945142 200 µM 1.94282564426231 0.0355152344845699 no 153 0.0260186141685334 239 2970608
SGTC_1506 4226-2149 212 µM 1.94149741414704 0.0356125451227274 no 154 0.0260989863859861 280 991114
SGTC_610 4215-0184 155 µM 1.9409186881824 0.0356550128536142 no 155 0.0261340704226539 242 5605015
SGTC_2069 5228469 200 µM 1.92927116189145 0.0365185854297059 no 156 0.0268486039335421 215 2835210
SGTC_2539 epi(13)torulosol 80 µM 1.92885233891718 0.0365499538506929 no 157 0.0268745980495002 243 6708597
SGTC_2745 rifampicin 24.3 µM 1.91072421428652 0.0379289572660879 no 158 0.0280200156705112 118 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3212 9128307 49.47 µM 1.90825881949536 0.0381197369055268 no 159 0.0281788863353866 254 27243542
SGTC_658 3253-0951 102 µM 1.90390232681728 0.0384587684357526 no 160 0.0284614530143213 338 1184878
SGTC_2148 5546263 113.568 µM 1.8984347134892 0.0388877433948463 no 161 0.0288194202036536 247 792097
SGTC_199 4063-0024 41.6 µM 1.89356548855893 0.0392730432262872 no 162 0.029141353989428 207 306215
SGTC_926 2268-1401 59.4 µM 1.8906998588058 0.0395012477829664 no 163 0.0293322106611144 250 2931578
SGTC_1137 ixabepilone 100 µM 1.88906016717354 0.0396323091181846 no 164 0.0294418835279687 298 154225 A novel microtubule stabilizer.
SGTC_2105 5350118 200 µM 1.88864805482856 0.039665305003362 no 165 0.0294695016610528 252 2133313
SGTC_1413 3910-0535 34.4 µM 1.88320312687864 0.0401033554657178 no 166 0.0298364227325651 244 2876951
SGTC_2904 7225135 42.03 µM 1.88251107235929 0.0401593124734179 no 167 0.0298833289777652 227 4446116
SGTC_1472 k841-0093 193 µM 1.87806881730012 0.0405200090162786 no 168 0.0301858757353172 281 X1472
SGTC_2384 9036245 200 µM 1.8775846855183 0.0405594773624995 no 169 0.0302190011891042 251 6462766
SGTC_3291 9121177 71.43 µM 1.87642526013887 0.0406541251923805 no 170 0.0302984543417375 212 17015612
SGTC_1730 st033808 45.1 µM 1.87470808300068 0.040794633458583 no 171 0.0304164471445178 329 1045166
SGTC_93 0109-0045 59.227 µM 1.8720083227806 0.0410163382193179 no 172 0.0306027260404958 346 88733
SGTC_670 4204-0025 119 µM 1.86960550216734 0.0412144792124237 no 173 0.0307693103255857 280 719039
SGTC_2585 alliin 100 µM 1.86684607057437 0.041442983553767 no 174 0.0309615433789166 288 87310 A garlic compound which reacts with lipids.
SGTC_1400 3771-8998 51.5 µM 1.8660230297535 0.0415113367389633 no 175 0.0310190717577744 192 670767
SGTC_1107 amlodipine 47 µM 1.86446186917681 0.0416412414016168 no 176 0.0311284357616874 282 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_951 1171-0579 82.7 µM 1.85312060959222 0.0425948657478139 no 177 0.0319325367222927 368 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_976 1348-1067 47.6 µM 1.85007028118512 0.0428543425510969 no 178 0.0321517103200933 292 5310671 YGL099W LSG1
SGTC_1370 2001-0092 44.6 µM 1.84999842158856 0.0428604706695969 no 179 0.0321568885438016 320 790957
SGTC_2192 5915882 198.485 µM 1.84787855132902 0.0430415700326233 no 180 0.0323099570116806 206 2876149
SGTC_1290 0986-0249 10.2 µM 1.84776137224759 0.0430515985807586 no 181 0.0323184356133408 212 53329
SGTC_2070 5230947 200 µM 1.82736542725717 0.0448261105850762 no 182 0.0338224219518067 258 2835538
SGTC_2215 7188065 200 µM 1.8216949677049 0.0453297850808025 no 183 0.0342506409785515 189 940217
SGTC_140 0062-0056 502.533 µM 1.81628913347981 0.04581418338497 no 184 0.0346630156361712 314 3758964
SGTC_638 3970-0837 4.09 µM 1.81256918295908 0.046149925241036 no 185 0.0349491472375353 292 4118451 YLR208W SEC13
SGTC_1272 0839-0021 27 µM 1.80466612286899 0.0468697696489425 no 186 0.0355634720424788 289 5027250
SGTC_179 1273-0063 6.77 µM 1.80221680654376 0.0470946828832489 no 187 0.035755650745715 257 3108139
SGTC_1892 st058411 7.36 µM 1.80104068873508 0.0472029892730947 no 188 0.0358482334943973 327 3934738
SGTC_3113 9123498 49.47 µM 1.79670625222352 0.0476038638435532 no 189 0.0361911329358833 244 8897275
SGTC_1841 st054148 70 µM 1.79615904863851 0.0476546657851241 no 190 0.0362346127713735 269 675442
SGTC_2238 6671620 73.2395 µM 1.79108932579392 0.0481274021183294 no 191 0.0366394809008927 286 729941
SGTC_2450 5739737 12.93 µM 1.79048293446073 0.0481841966749305 no 192 0.0366881541490823 272 2262825
SGTC_2753 fluvastatin 17.09 µM 1.78886024756821 0.0483364411570019 no 193 0.036818662620089 321 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2505 galangin 7.89 µM 1.78597063626991 0.0486085040718316 no 194 0.0370520063314398 220 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1844 rapamycin 4 nM 1.78246251468682 0.0489404448596962 no 195 0.0373369194264625 465 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2211 7117706 200 µM 1.77548617013814 0.0496059319230799 no 196 0.0379088235471313 247 822771
SGTC_1167 k781-0610 148 µM 1.77546112473627 0.0496083339966716 no 197 0.0379108895141011 338 4525169
SGTC_1829 berberine 14.4 µM 1.77295460333195 0.0498492012249083 no 198 0.0381181147779733 275 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2951 9072950 58.06 µM 1.76841650315364 0.0502876681118287 no 199 0.0384956498141352 323 16488155
SGTC_1392 3455-1037 33.9 µM 1.76549229883809 0.0505718266399381 no 200 0.0387405316983574 287 981132
SGTC_408 cantharidin 100 µM 1.76040043454224 0.0510696780835384 no 201 0.0391699678646072 339 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_836 0330-0104 1.35 µM 1.74759094334297 0.0523393686198808 no 202 0.0402674423534411 303 46494820
SGTC_900 1112-0045 141 µM 1.74448099559556 0.0526513806391839 no 203 0.0405376262140847 223 56211 YIL048W NEO1
SGTC_3099 9120367 49.47 µM 1.74228878970956 0.0528722038700079 no 204 0.0407289620147345 283 24824940
SGTC_751 0833-0568 350 µM 1.73883139426676 0.053221963273676 no 205 0.0410322123286878 287 6954252
SGTC_1135 dihydrocapsaicin 536.708 nM 1.73293412136466 0.0538227770553008 no 206 0.0415536893510536 334 107982 A Capsaicinoid.
SGTC_3106 9121286 49.47 µM 1.73156257404375 0.0539632771423763 no 207 0.0416757373336477 272 15943471
SGTC_2628 lathosterol 100 µM 1.72942049283936 0.0541832907113256 no 208 0.0418669324647449 321 6710616
SGTC_2766 oltipraz 83.91 µM 1.72822924444994 0.0543059508570191 no 209 0.041973566311608 298 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_73 0327-0325 16.231 µM 1.72223956285876 0.0549260274667939 no 210 0.0425130653921612 380 53298
SGTC_2329 6138490 200 µM 1.72194551306299 0.0549566122128841 no 211 0.0425396946157949 298 720019
SGTC_2011 4012611 177 µM 1.72134388549826 0.0550192307143997 no 212 0.0425942201904737 326 2049887
SGTC_44 0929-0055 61.211 µM 1.71777976694742 0.0553913477340175 no 213 0.042918396689294 289 1379590
SGTC_1293 1000-1278 195 µM 1.71442776404365 0.0557431292189655 no 214 0.0432250965565431 332 678847
SGTC_2740 felodipine 17.08 µM 1.71189045294575 0.0560105819872258 no 215 0.0434584292016255 242 3333 L-type calcium channel blocker
SGTC_1075 aripiprazole 15.2 µM 1.711596657066 0.0560416156814039 no 216 0.0434855124044665 382 60795 An atypical antipschotic. YIL048W NEO1
SGTC_135 0933-0004 26.348 µM 1.7086257765244 0.0563561925886487 no 217 0.0437601454026052 326 21230617 YGL099W LSG1
SGTC_89 0302-0250 142.109 µM 1.70394835209575 0.0568542887971548 no 218 0.0441953683131966 352 4203518 YLR208W SEC13
SGTC_1228 0124-0032 52.5 µM 1.70135308968699 0.0571321485677284 no 219 0.044438352209906 336 X1228
SGTC_2391 6285546 200 µM 1.70082850028658 0.0571884429817795 no 220 0.0444875979271463 354 846083
SGTC_297 0986-0032 24 µM 1.67999643572117 0.0594594543551339 no 221 0.0464790046058914 285 2847425
SGTC_55 0767-0285 6.563 µM 1.67790856229747 0.0596909080687022 no 222 0.0466824753796207 398 3116166
SGTC_2796 7949634 45.45 µM 1.676313699499 0.0598681836129086 no 223 0.0468383814601366 346 2971588
SGTC_1669 st015249 58.4 µM 1.67488266102532 0.0600276001989058 no 224 0.0469786281097238 277 722793
SGTC_3216 9129716 49.47 µM 1.67395061819931 0.060131607678224 no 225 0.047070152432062 318 8056934
SGTC_2345 9052315 157.45 µM 1.67371646657261 0.0601577590267107 no 226 0.0470931680031325 340 6469265
SGTC_194 1486-1323 56.904 µM 1.66536789139029 0.0610960052423978 no 227 0.0479196906189377 330 5178754
SGTC_748 act1.228 77.9 µM 1.66406290485955 0.0612436929096162 no 228 0.0480499295783608 407 4421505 YNR035C ARC35
SGTC_2360 9040895 200 µM 1.66319050157524 0.061342579831459 no 229 0.0481371541798268 329 4914414
SGTC_92 0063-0024 660.874 µM 1.65811073393616 0.0619208513201514 no 230 0.0486475588687458 370 3594437
SGTC_2351 9026858 72.31 µM 1.6570678280405 0.0620400985421705 no 231 0.048752881325405 300 1409300
SGTC_2557 derrustone 83.84 µM 1.65617301479269 0.0621425554175156 no 232 0.048843393190623 409 629853 An antioxidant.
SGTC_664 1222-0054 14.9 µM 1.65574311292873 0.0621918264655436 no 233 0.0488869262173396 354 6813991
SGTC_312 4092-0653 6.84 µM 1.65284283214976 0.0625250242930272 no 234 0.0491814271846289 456 1148278
SGTC_1521 st012942 49.4 µM 1.65207028632741 0.0626140122821852 no 235 0.0492601117088751 385 24207259
SGTC_361 000s-0510 1.45 µM 1.65183356579425 0.0626412993914945 no 236 0.0492842420290467 375 660
SGTC_890 0929-0006 47.2 µM 1.65107218879365 0.0627291272426191 no 237 0.0493619176805136 306 1378169
SGTC_2663 amphotericin b 100 µM 1.65030741903193 0.0628174430409881 no 238 0.0494400378220597 328 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3016 9080866 49.47 µM 1.64401517181911 0.0635477555154844 no 239 0.0500865342544018 357 17066299
SGTC_500 h-89 112 µM 1.64183406711543 0.0638024428242297 no 240 0.0503121984249785 366 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_546 peri-Naphthalide 147 µM 1.64000929380759 0.0640161307573934 no 241 0.0505016172870506 341 223824 A penicillin ester.
SGTC_3228 9131799 49.47 µM 1.63945471271697 0.0640811844657076 no 242 0.0505592974895804 323 17015818
SGTC_903 1134-0042 114 µM 1.63935409547865 0.0640929926183766 no 243 0.0505697679883896 350 701009
SGTC_934 2950-0684 338 µM 1.63581816224962 0.0645090349072424 no 244 0.050938824846258 371 1121253
SGTC_62 0180-0423 3.232 µM 1.63363888793367 0.0647664941361942 no 245 0.0511673486411539 346 30102 YGL099W LSG1
SGTC_1166 k206-0078 225 µM 1.63354580031795 0.0647775092400961 no 246 0.0511771281635509 383 5404595
SGTC_2515 chrysin 20.77 µM 1.63292258989608 0.0648512915132067 no 247 0.0512426392078256 317 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_372 0155-0182 15.9 µM 1.62608246716755 0.0656653920046391 no 248 0.051966056629069 368 771486
SGTC_905 2-aminofluorene 215 µM 1.61619873401055 0.0668557057800942 no 249 0.0530256762128721 391 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2236 dapsone 200 µM 1.61230896587504 0.0673287085364125 no 250 0.0534473616231207 364 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2047 4141938 200 µM 1.60794753538257 0.0678621381359529 no 251 0.0539233348537117 308 3807862
SGTC_1202 1988-0068 29.6 µM 1.60445788734819 0.0682912891424097 no 252 0.0543065800002819 377 2850480
SGTC_1971 st069429 63.5 µM 1.60399110090208 0.0683488522069003 no 253 0.0543580070982591 320 1246522 YGL099W LSG1
SGTC_1441 4106-0040 13 µM 1.60139110597427 0.0686701630746443 no 254 0.0546451607071698 349 2904180
SGTC_3029 9088683 49.47 µM 1.59420377839073 0.0695644441312598 no 255 0.0554452002641652 342 25236615
SGTC_206 4546-0025 72.014 µM 1.592402369507 0.0697899832313306 no 256 0.0556471620868675 452 6620745 YIL048W NEO1
SGTC_3332 9141069 11.198 µM 1.59177985185536 0.0698680540938911 no 257 0.0557170894073053 327 17332883
SGTC_1068 loratadine 26.9 µM 1.59053881928993 0.0700238943609135 no 258 0.0558567013276038 354 3957 A H1 histamine antagonist.
SGTC_141 0443-0274 32.331 µM 1.58932936334013 0.0701760266328589 no 259 0.0559930263986238 511 1627241
SGTC_1978 st071761 42 µM 1.5876084125699 0.0703929357057838 no 260 0.0561874573591368 345 5147680
SGTC_789 1309-1135 70.6 µM 1.58759989183466 0.0703940109424161 no 261 0.056188421344302 420 3092424
SGTC_2695 st077686 51.995 µM 1.57904462313483 0.0714799903629227 no 262 0.0571629110655779 350 2876092
SGTC_91 0417-1751 58.384 µM 1.57392302440883 0.0721362353767923 no 263 0.0577526231276031 485 6795624
SGTC_250 brefeldin a 552.239 µM 1.57084809907105 0.072532447167014 no 264 0.0581089682723984 298 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1186 1319-0216 26 µM 1.57007667974436 0.0726321075463139 no 265 0.05819863659374 410 4565136
SGTC_630 4356-0227 183 µM 1.56938132388154 0.0727220310572456 no 266 0.0582795565663715 352 779312
SGTC_3206 9114350 49.47 µM 1.56592865091345 0.0731697942075912 no 267 0.0586826607684239 353 17087243
SGTC_1113 artemisinin 1.17947 µM 1.56462381710417 0.0733395609839032 no 268 0.0588355704893182 401 2240 An anti-malaria and mitochondrial poison.
SGTC_958 1222-0007 33 µM 1.56425152020967 0.073388054267256 no 269 0.0588792561756723 410 7312461
SGTC_1324 1418-0026 34.4 µM 1.54484298966216 0.075950211874638 no 270 0.0611921230011071 418 1372513
SGTC_2140 5586273 200 µM 1.54419787032323 0.0760365303184245 no 271 0.0612702023132777 337 854421
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.54100200903228 0.0764652456781544 no 272 0.0616581485139992 354 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3097 9117246 49.47 µM 1.52761316668548 0.0782813283349378 no 273 0.0633043053701131 406 16423892
SGTC_2274 7947094 46.08 µM 1.52168985148288 0.0790951357757168 no 274 0.0640434058378738 437 2971028
SGTC_198 3454-2873 16.191 µM 1.52094547532947 0.0791978575221751 no 275 0.0641367603561486 402 710957
SGTC_1767 st044992 70.3 µM 1.51864300213162 0.0795162315719645 no 276 0.064426190399014 439 9600693
SGTC_2665 lovastatin 100 µM 1.51827680184119 0.079566956992188 no 277 0.0644723166241142 391 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1557 sumaresinolic acid 42.3 µM 1.51633064860928 0.0798369456230707 no 278 0.0647178827779458 399 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3163 9099914 49.47 µM 1.51606734399395 0.0798735268586881 no 279 0.0647511623370403 299 16268368
SGTC_2262 9014885 67.46 µM 1.5108160539199 0.0806057450237303 no 280 0.0654176616543353 298 6457424
SGTC_793 0488-0545 106 µM 1.50947284843398 0.0807938477914215 no 281 0.0655889944127664 412 292548
SGTC_1885 st057546 99.9 µM 1.50856971707323 0.0809205087083269 no 282 0.0657043889376915 439 702008
SGTC_3112 9123419 49.47 µM 1.50499280849551 0.0814236299809288 no 283 0.0661629628290676 450 17015854
SGTC_1519 esterone 74 µM 1.49932652091339 0.0822254632322446 no 284 0.0668944727284962 436 698 A steroid.
SGTC_14 0354-0009 295 µM 1.49817601069431 0.0823889952287345 no 285 0.067043763314584 424 1713507
SGTC_2145 5634607 200 µM 1.49815854200487 0.0823914800910747 no 286 0.0670460320417989 360 308662
SGTC_1016 4226-1401 38 µM 1.49533889963574 0.0827933048151381 no 287 0.0674130089213031 428 2901613
SGTC_1663 st014140 55.4 µM 1.49345974005532 0.0830619198540168 no 288 0.0676584426358315 484 4207120
SGTC_2443 5493264 126.67 µM 1.48544633334382 0.0842147505519097 no 289 0.0687128148483975 420 5340055
SGTC_784 4579-0127 173 µM 1.48446405599791 0.0843568859294034 no 290 0.0688429260196217 449 1948547
SGTC_2896 9052656 71.43 µM 1.48401141839556 0.0844224430748122 no 291 0.0689029456965535 577 6469436
SGTC_233 rapamycin 362 pM 1.4831183993249 0.0845518943578528 no 292 0.0690214781774804 419 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_166 k072-0058 166.424 µM 1.47655813624086 0.0855074326791948 no 293 0.069897060289969 437 5846229
SGTC_541 4513-1321 94 µM 1.47558933503175 0.0856492265195186 no 294 0.0700270849489155 437 747515
SGTC_465 cgp-37157 41 µM 1.47360762604541 0.0859398178792212 no 295 0.0702936334434775 291 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1960 st011366 51.8 µM 1.47350078006694 0.0859555063622215 no 296 0.0703080268297819 398 3972846
SGTC_666 0272-0154 136 µM 1.47294588361185 0.0860370177728942 no 297 0.0703828142369914 479 6870312
SGTC_2186 6124449 200 µM 1.47103624929106 0.086317975153337 no 298 0.0706406569712307 409 3834182 YLR033W RSC58
SGTC_749 1000-0129 128 µM 1.46947345671338 0.0865484130615071 no 299 0.0708522080618263 480 708470
SGTC_3008 9078912 71.4286 µM 1.46621939002587 0.0870297090205601 no 300 0.0712942638963183 407 16648731
SGTC_1045 1348-1485 165 µM 1.46515432204855 0.0871876724000402 no 301 0.071439409361206 513 6810614
SGTC_2543 pimpinellin 60.67 µM 1.46196745746928 0.0876616043281754 no 302 0.0718750638764287 422 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2840 9008771 71.43 µM 1.45920879742529 0.0880734059502931 no 303 0.0722538240951767 379 2992978
SGTC_2060 5238662 140 µM 1.45888907072003 0.0881212265727651 no 304 0.0722978208624616 434 790130
SGTC_1305 1181-0477 144 µM 1.45810645672172 0.0882383616183627 no 305 0.0724056009827673 423 6252086
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.45652800350049 0.0884749641597104 no 306 0.0726233570549727 453 3256 An antibiotic and ribosome inhibitor.
SGTC_2435 5706476 10.6 µM 1.45629131708397 0.0885104830286485 no 307 0.0726560524109281 470 5725375
SGTC_1930 st074634 34.3 µM 1.45542221142319 0.0886409984092651 no 308 0.0727762055093521 462 684253 YOR116C RPO31
SGTC_3281 9140613 49.47 µM 1.45531152580264 0.0886576305811614 no 309 0.0727915186150275 400 16013766
SGTC_2004 4023728 41.89 µM 1.45437245977521 0.0887988328378113 no 310 0.0729215355471824 476 360084 YDR527W RBA50
SGTC_1410 3909-8106 77.9 µM 1.4541011779944 0.0888396551642129 no 311 0.0729591285211277 423 1039210
SGTC_2122 5258151 111.688 µM 1.4524591670621 0.0890870423179513 no 312 0.0731869874967691 450 2173356
SGTC_1757 st041620 31.8375 µM 1.45195703670315 0.0891627960953141 no 313 0.0732567758445106 440 5289815
SGTC_3270 9137563 49.47 µM 1.45096071622929 0.0893132476466866 no 314 0.0733953996798702 388 17015724
SGTC_202 3594-0513 34.79 µM 1.44910659634663 0.0895937357199873 no 315 0.0736539080901143 403 708429
SGTC_1236 0330-0013 258 µM 1.44727683656348 0.0898711802816063 no 316 0.0739097019709654 417 4617066
SGTC_957 1187-1561 14.1 µM 1.44628887135093 0.0900212496367272 no 317 0.0740480979078737 473 1538454
SGTC_1661 st013063 9.66 µM 1.44376571428015 0.0904053555316184 no 318 0.0744024446811591 487 721395
SGTC_913 3487-1245 167 µM 1.43972644078483 0.0910227947389152 no 319 0.0749724048339062 473 4016153
SGTC_3321 9137793 26.8275 µM 1.43695333677086 0.0914484958188741 no 320 0.0753656265224846 486 4904192
SGTC_2987 9018338 71.43 µM 1.4340325875456 0.0918984557697012 no 321 0.0757814817828634 467 5055682
SGTC_1511 0906-3109 28.5 µM 1.43168241141155 0.0922617041984819 no 322 0.076117366150648 580 2882180
SGTC_2423 st077119 87.2 µM 1.42903153840907 0.0926727031471361 no 323 0.0764975844405227 449 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2701 st077767 14.721 µM 1.42733350581456 0.0929366815692227 no 324 0.0767418936062723 520 5721188
SGTC_1693 xanthone 101.9 µM 1.42465813723928 0.0933537252314932 no 325 0.0771280228603332 488 7020 An insecticide.
SGTC_2531 methyl deoxycholate 70.07 µM 1.42330202195957 0.0935656474000714 no 326 0.0773243105507732 451 16667744 Haematoxylin.
SGTC_122 0236-0016 402.397 µM 1.41712415885301 0.0945355681528314 no 327 0.0782233151838276 544 6808838
SGTC_120 rhodamine 6G 52.259 µM 1.41693517388648 0.0945653550842025 no 328 0.0782509407706013 563 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1067 clotrimazole 1.36 µM 1.41468571788074 0.0949204353247176 no 329 0.078580331857897 494 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3050 9093513 49.47 µM 1.41428701615988 0.0949834733780412 no 330 0.0786388238116876 454 25236664
SGTC_2320 7373003 200 µM 1.41413058892146 0.0950082142452297 no 331 0.0786617816443534 452 5415828
SGTC_596 1155-0152 116 µM 1.4136896851417 0.0950779740777589 no 332 0.0787265176276032 539 280313
SGTC_370 0180-0345 38.7 µM 1.41362821052707 0.0950877035923645 no 333 0.0787355468836382 420 3989527
SGTC_1667 st014849 34.6 µM 1.40933107751528 0.0957696241785698 no 334 0.0793686467493026 482 5348460
SGTC_952 1185-0122 232 µM 1.40810161556474 0.095965390257942 no 335 0.0795504913664303 484 678600
SGTC_2984 9022109 38.96 µM 1.40461911153081 0.0965215032258411 no 336 0.0800672852353464 401 6459207
SGTC_3051 9093778 49.47 µM 1.40197309926126 0.0969456189955936 no 337 0.0804616399327424 388 17217378
SGTC_2374 9071832 200 µM 1.39861977882973 0.0974850690796489 no 338 0.0809635159772422 434 17381698
SGTC_1766 st045414 44.774 µM 1.39791475456813 0.0975987662000282 no 339 0.0810693337011188 506 253960
SGTC_1524 corynanthine 62.1 µM 1.3875262178727 0.0992853809739973 no 340 0.0826406811095795 460 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1339 1486-1321 22.7 µM 1.38749360415 0.0992907092707072 no 341 0.0826456500306678 495 3469382
SGTC_2612 dictamnine 15.46 µM 1.38364585754412 0.099920806621435 no 342 0.0832334597291271 494 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2053 5265679 138 µM 1.38037701409244 0.100458394431953 no 343 0.0837352968388389 525 764595
SGTC_2346 9031566 143.75 µM 1.37692765376842 0.101027954844427 no 344 0.0842673082102206 468 4771086
SGTC_551 k048-0028 34.9 µM 1.37424339653293 0.10147280687542 no 345 0.0846830661851859 532 6836383
SGTC_1769 st044406 64.4 µM 1.37408933179039 0.101498382680702 no 346 0.0847069754920006 544 670903
SGTC_1724 st037281 8.293 µM 1.3737339963858 0.101557388699117 no 347 0.0847621392944915 522 574124 YDL195W SEC31
SGTC_834 0312-0008 75.7 µM 1.3733512913306 0.101620967583567 no 348 0.0848215822057079 532 6385573 YIL048W NEO1
SGTC_1983 st071813 46.9 µM 1.37162264042813 0.101908509916745 no 349 0.0850904710024665 505 11838595
SGTC_1950 st077106 7.18 µM 1.3687162647333 0.102393287934469 no 350 0.0855439920725112 506 13831864
SGTC_3057 9095946 49.47 µM 1.36766685076515 0.102568739634011 no 351 0.0857081903323631 478 24540043
SGTC_644 1498-1197 63.3 µM 1.36591206912107 0.102862609969676 no 352 0.0859832820533993 543 6741615
SGTC_90 0870-0863 4.608 µM 1.36187008171083 0.103541841268869 no 353 0.0866194447881038 552 1738164
SGTC_3098 9119039 49.47 µM 1.36167543235216 0.103574632859064 no 354 0.0866501689299986 496 17161528
SGTC_2129 girgensonine 121.053 µM 1.36155558123925 0.103594827316506 no 355 0.0866690907039502 571 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3314 9135860 59.4275 µM 1.35955085635756 0.1039330395375 no 356 0.0869860493124937 513 25252478
SGTC_3033 9090887 49.47 µM 1.35843549357642 0.104121556003876 no 357 0.0871627690866474 538 19325384
SGTC_2154 5570129 200 µM 1.35759068536113 0.104264508762215 no 358 0.0872968001184503 548 673366
SGTC_1162 k048-0130 20.1 µM 1.35659878047339 0.104432533727544 no 359 0.0874543647396795 503 6797406
SGTC_2433 5607874 27.82 µM 1.35594503944852 0.104543382219611 no 360 0.0875583278389482 509 2252428
SGTC_2863 9028737 58.44 µM 1.35502933876716 0.104698791933496 no 361 0.0877041048715363 434 6460917
SGTC_1213 1315-0166 115 µM 1.35286348314785 0.105067039586278 no 362 0.0880496236368949 446 768401
SGTC_2292 7671323 168.05 µM 1.34351576452507 0.106667131506774 no 363 0.089552512445839 526 937504
SGTC_1121 fusaric acid 630.51 nM 1.34317740028451 0.106725378907309 no 364 0.0896072688537018 528 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2970 9090938 41.86 µM 1.34314486795073 0.106730980365279 no 365 0.089612534769289 608 17217104
SGTC_2541 muurolladie-3-one 83.07 µM 1.33884966862387 0.107472397394203 no 366 0.0903098087966094 513 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2193 5925765 200 µM 1.33518176298146 0.108108466383739 no 367 0.0909084320881349 445 877370
SGTC_1377 2944-0135 198 µM 1.33444009800714 0.108237410771475 no 368 0.0910298330739219 544 1894137
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.33284230763986 0.108515575434423 no 369 0.0912917792516059 547 165521
SGTC_2584 androsterone 48.74 µM 1.32943202176622 0.109111002900966 no 370 0.091852739568086 685 2754130 A steroid.
SGTC_384 k007-0144 5.16 µM 1.3290841068308 0.109171879714311 no 371 0.091910111545247 585 6824886
SGTC_2704 st078022 71.1 µM 1.3275438755734 0.109441676626062 no 372 0.0921644180787035 509 54697681
SGTC_2249 haloperidol 116.36 µM 1.3243224493545 0.110007510024703 no 373 0.0926979889395675 662 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_710 3448-4187 58 µM 1.32431597866047 0.110008648690177 no 374 0.0926990629869893 636 3946412
SGTC_1837 st055472 66.5 µM 1.31914922154783 0.110920557878501 no 375 0.0935596151939708 537 676091
SGTC_3135 9127742 49.47 µM 1.31882635484077 0.110977721619383 no 376 0.0936135856423052 500 3643468
SGTC_231 b-estradiol 524 µM 1.31762480542566 0.111190642031215 no 377 0.0938146388028268 461 450 A steroid.
SGTC_1438 4092-1045 4 µM 1.31275109687512 0.112057286010152 no 378 0.0946334167752887 539 1351342
SGTC_1158 4092-0494 91.8 µM 1.31160801835867 0.112261245750569 no 379 0.0948262130895552 564 1148199
SGTC_2017 5132927 60.65 µM 1.30771653459368 0.112957592651536 no 380 0.095484736501072 546 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2738 aclarubicin 5.55 µM 1.30479309763239 0.113482740248825 no 381 0.0959816550566702 426 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_557 1315-0110 16.2 µM 1.30168485680786 0.114042991890929 no 382 0.0965120691586337 537 6833801
SGTC_1047 2043-3044 82 µM 1.29859754818792 0.114601418331299 no 383 0.0970410399213304 555 669592
SGTC_745 0469-0705 296 µM 1.29752974629545 0.114795012469991 no 384 0.0972244884979023 624 3486736
SGTC_1574 spiramycin 23.7 µM 1.29682438214807 0.114923023625355 no 385 0.0973458096893596 554 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1718 roemerine 11.9335 µM 1.29420178448983 0.115399869326259 no 386 0.0977978652820086 618 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1733 st037357 54.9 µM 1.29323463350107 0.115576072949757 no 387 0.0979649603158706 570 1272339 YGL099W LSG1
SGTC_1331 1472-0049 76.2 µM 1.29061448606725 0.116054393343536 no 388 0.0984186951636586 522 24051409
SGTC_1281 0884-0031 11.8 µM 1.2892778260484 0.116298947543017 no 389 0.0986507584758118 579 1548255
SGTC_518 1021-0119 62.6 µM 1.28753657199637 0.116618074030932 no 390 0.0989536654816869 552 1097762
SGTC_2312 7706453 155.7 µM 1.2866501668699 0.11678076729545 no 391 0.0991081248258176 545 976098
SGTC_421 streptovitacin 30 mM 1.28615660108355 0.116871427444319 no 392 0.0991942068658975 593 91467 include heat shock
SGTC_3334 9142812 21.919 µM 1.28542546322909 0.117005817453355 no 393 0.0993218239458678 554 45283678
SGTC_2142 5622915 118.518 µM 1.2848285587018 0.117115615283634 no 394 0.0994261001240825 514 5322196
SGTC_1994 st072947 40.9 µM 1.28386839318859 0.117292386414258 no 395 0.0995940040031258 566 5286565 YDL195W SEC31
SGTC_1870 st057514 26.5 µM 1.28258512623808 0.117528937033078 no 396 0.0998187319314661 560 5393161
SGTC_3333 9141820 12.094 µM 1.2806676686682 0.117883020028652 no 397 0.100155210298573 501 1939433
SGTC_1054 3429-0080 167 µM 1.27192800845525 0.119506468313609 no 398 0.101699349638703 591 1162877
SGTC_804 1595-0054 20.9 µM 1.27131846419423 0.119620280625525 no 399 0.101807688098488 540 761523 Stimulates phospholipase C.
SGTC_1307 1187-1599 12.2 µM 1.2693044976124 0.119996866061503 no 400 0.102166241433423 564 1538471
SGTC_167 3672-0051 66.205 µM 1.26855930859068 0.120136418249687 no 401 0.102299142541079 528 3237971
SGTC_2032 5185112 25.99 µM 1.26733971431453 0.120365059396327 no 402 0.102516922903819 525 5718189
SGTC_2640 pentamidine 10.38 µM 1.26482443224962 0.120837574697776 no 403 0.102967135517888 631 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1297 1068-0111 14.1 µM 1.26335202005419 0.121114783806611 no 404 0.103231349492094 543 767057
SGTC_2389 9091542 195.52 µM 1.26191020758507 0.121386665142648 no 405 0.103490549271575 603 3626624 YOL127W RPL25
SGTC_1443 4112-3303 14 µM 1.26052353365469 0.121648553595203 no 406 0.103740281890091 592 704433
SGTC_1154 4088-0362 150 µM 1.25784595879635 0.12215536575365 no 407 0.104223735463984 650 6618304
SGTC_780 0109-0199 192 µM 1.25734683799197 0.122250003183242 no 408 0.104314035267236 620 610414
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.25504944455958 0.122686271612236 no 409 0.104730405637723 550 641818 YHR062C RPP1
SGTC_1637 st007924 17.4 µM 1.25468200112781 0.122756149242468 no 410 0.104797111101048 581 683336
SGTC_22 0964-0034 14.468 µM 1.25449097827221 0.122792487559342 no 411 0.104831801429228 606 138402
SGTC_1043 0916-0009 19.3 µM 1.25415860290237 0.122855733375502 no 412 0.104892181620469 685 3101130
SGTC_86 0417-1630 471.922 µM 1.25281383307343 0.123111855131486 no 413 0.105136733092666 702 3634867
SGTC_3213 9129884 49.47 µM 1.25207468529244 0.123252790787604 no 414 0.105271325505017 497 17190742
SGTC_1245 0418-0076 17.2 µM 1.25140705683962 0.123380186769065 no 415 0.105393001980688 602 6790114
SGTC_3247 9135149 49.47 µM 1.24999981474609 0.123649016931778 no 416 0.105649807503317 523 8934436 YOR116C RPO31
SGTC_718 1130-0073 349 µM 1.2488263758957 0.123873496270999 no 417 0.105864292301044 612 6740020
SGTC_1063 disulfiram 1.84 µM 1.24785885364756 0.124058798117303 no 418 0.106041375605197 579 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1860 st056228 74.6 µM 1.24643050648215 0.124332712478191 no 419 0.106303193659653 562 688679
SGTC_803 4488-1585 147 µM 1.24479664142836 0.124646557337598 no 420 0.106603255511408 579 747204
SGTC_1062 mesoridazine 14.2 µM 1.24457961908648 0.124688286214716 no 421 0.106643157952541 597 4078 A neuroleptic.
SGTC_3293 9120939 62.045 µM 1.24268342690199 0.125053299848425 no 422 0.106992256728211 571 934087
SGTC_197 4544-0043 41.561 µM 1.24161146429868 0.12525998065425 no 423 0.107189974933335 630 896523
SGTC_855 0428-0020 25 µM 1.2410843297366 0.125361702781123 no 424 0.107287298875497 546 6812414
SGTC_3053 9095903 49.47 µM 1.2380989507881 0.125938884894538 no 425 0.107839686444378 575 17174018
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.23621876797222 0.126303342125999 no 426 0.108188628129486 563 5355888
SGTC_1133 3473-0247 50 µM 1.23176288425515 0.127170009859252 no 427 0.109018835825158 630 711311
SGTC_3349 9149703 23.001 µM 1.22980127718476 0.127552850430788 no 428 0.109385764922581 565 4910494
SGTC_1482 3346-2049 8.48 µM 1.22941819443879 0.127627708894662 no 429 0.109457526014328 575 3826804
SGTC_124 0136-0217 7.121 µM 1.22881062711518 0.12774649666739 no 430 0.109571408073829 690 3976905
SGTC_1697 st025554 27.742 µM 1.22861951958869 0.127783876700725 no 431 0.109607246738789 566 1269519
SGTC_329 k048-0121 21.3 µM 1.22585960143988 0.128324555758178 no 432 0.110125756814563 572 6832902
SGTC_2109 5483026 200 µM 1.2228911359258 0.128907860798576 no 433 0.110685408480276 606 759335
SGTC_2859 9028643 45.46 µM 1.21704308892536 0.130062378939988 no 434 0.111793911023502 561 17151580
SGTC_3011 9081274 71.4286 µM 1.2154052622433 0.130386996642609 no 435 0.112105780995906 648 6625322
SGTC_2043 5101342 149 µM 1.21391995874772 0.130681868396877 no 436 0.112389145278153 606 678451
SGTC_833 3852-0053 558 µM 1.21374868977543 0.130715899407416 no 437 0.112421852628767 680 3123681
SGTC_2626 ethyl orsellinate 100 µM 1.21342634177203 0.130779966317709 no 438 0.112483430086488 584 75653 A natural product.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.21181758771886 0.131100031849446 no 439 0.112791107163344 686 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2354 9060492 162 µM 1.21106815516176 0.131249317882042 no 440 0.112934642448131 675 6471895
SGTC_1104 tacrolimus 29.8 µM 1.20871018471413 0.131719788272608 no 441 0.113387103741828 649 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2005 4024620 188 µM 1.20767701437841 0.13192629617808 no 442 0.113585761383589 608 236743
SGTC_3001 9076041 71.4286 µM 1.20676387237816 0.132108998888372 no 443 0.113761546493603 595 16004211
SGTC_2769 toremifene 3.73 µM 1.20038791884257 0.133389570252384 no 444 0.114994359323975 589 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3340 9146634 11.102 µM 1.19975103606526 0.133517951751178 no 445 0.115118022767994 625 4907387
SGTC_1064 honokiol 6.76 µM 1.19900930211751 0.133667576013352 no 446 0.115262164303127 631 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1226 3909-7979 35.4 µM 1.19816543601048 0.133837942747176 no 447 0.115426309187671 667 6615510
SGTC_769 0302-0231 76 µM 1.19777075791454 0.133917674859783 no 448 0.115503137112192 722 571869 YER009W NTF2
SGTC_672 1441-0018 53.7 µM 1.19762319593398 0.133947493430451 no 449 0.115531870814713 584 251141
SGTC_730 1436-0052 41.2 µM 1.19351026206409 0.134780450318363 no 450 0.116334797779991 588 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_766 1391-0721 126 µM 1.19341806354398 0.134799163125096 no 451 0.116352842032123 617 1020919 YIL115C NUP159
SGTC_1446 4239-0190 62 µM 1.18111440337929 0.137312342333506 no 452 0.118778639415501 687 1340085
SGTC_927 2425-1185 123 µM 1.17857841475242 0.137834302321267 no 453 0.119283045480512 617 730375
SGTC_392 N-ethylmaleimide 8.33 µM 1.17807023416679 0.137939059208346 no 454 0.119384303735368 601 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1776 st049249 45.9 µM 1.17798482071189 0.137956671758718 no 455 0.119401328868625 649 1822314
SGTC_1309 pyrazolanthrone 13.4 µM 1.17669880515517 0.138222038044254 no 456 0.119657872466623 685 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2804 7954240 19.48 µM 1.1760352121316 0.138359104934599 no 457 0.119790402707125 675 828705
SGTC_2289 7946404 165.07 µM 1.17504514491823 0.13856377810376 no 458 0.119988327467395 706 1246120 YPR165W RHO1
SGTC_955 1216-0110 33 µM 1.17320750406172 0.138944213788283 no 459 0.120356301764861 677 3619719
SGTC_2791 5663188 71.43 µM 1.17064041732104 0.139476851881848 no 460 0.120871672056654 601 54690634
SGTC_743 1275-0778 158 µM 1.1705472346878 0.139496212188318 no 461 0.120890408638846 686 2849257 YMR203W TOM40
SGTC_3232 9132874 49.47 µM 1.16718522289509 0.140195951181522 no 462 0.1215677885814 613 3784940
SGTC_468 gf-109203x 121 µM 1.16549967158784 0.140547662525157 no 463 0.121908396539167 498 2396 A protein kinase C inhibitor.
SGTC_1926 methyl fluorone black 53.6 µM 1.16492878044212 0.140666921766889 no 464 0.122023911254683 585 72721 Reacts with homocysteine.
SGTC_1473 k844-0725 134 µM 1.16163638037829 0.141356044559257 no 465 0.12269159893908 738 54682906
SGTC_2181 6316240 54.2555 µM 1.16145688656364 0.141393679555658 no 466 0.122728073203406 601 12779990
SGTC_1430 4049-0248 69.1 µM 1.16085539743782 0.141519845055795 no 467 0.122850354993449 719 22774488
SGTC_2210 7115885 190.385 µM 1.15987459286509 0.141725737522951 no 468 0.123049934212826 678 2927039
SGTC_336 4111-0029 111 µM 1.159870687327 0.141726557786707 no 469 0.123050729386097 594 3131175
SGTC_2263 7948595 193.29 µM 1.15896481334713 0.141916901565424 no 470 0.123235263975061 591 2971371
SGTC_2407 paclitaxel 400 µM 1.15571139387177 0.142601942234867 no 471 0.123899613060183 692 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2888 9058547 12.99 µM 1.15400181902449 0.142962805402285 no 472 0.124249711582765 559 16476514
SGTC_1676 st018489 23.4 µM 1.1539346632362 0.142976993471226 no 473 0.124263478318587 656 3696235
SGTC_1378 2093-0007 380 nM 1.15280438475757 0.143215931280665 no 474 0.124495342129539 649 3618014
SGTC_1502 4534-4282 27.7 µM 1.1524495748163 0.143290992729385 no 475 0.124568189705716 629 3278949
SGTC_1455 4262-0120 131 µM 1.15027980706717 0.143750593652853 no 476 0.125014322484351 686 1529587
SGTC_2506 ethyl hematommate 54.16 µM 1.14985381518855 0.143840944077855 no 477 0.125102042922292 585 3940691 An allergen.
SGTC_2324 6149169 200 µM 1.14691935209853 0.144464367599259 no 478 0.125707476882441 632 2888231
SGTC_1076 itraconazole 331 nM 1.14415139889445 0.14505408257979 no 479 0.126280427384287 677 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_975 1335-0046 28.5 µM 1.1441130297116 0.145062268539209 no 480 0.126288382353665 657 16486740
SGTC_767 0929-0023 86 µM 1.14145195091141 0.145630761020854 no 481 0.12684094815875 772 1204563
SGTC_2954 9074818 52.69 µM 1.14119835293176 0.145685015820989 no 482 0.126893694803951 645 16648742
SGTC_1471 k673-0312 37 µM 1.13933470792489 0.146084141218766 no 483 0.127281788641675 656 24099884
SGTC_1638 st008370 60.6 µM 1.13916754341805 0.146119977678839 no 484 0.127316640041443 675 24207134
SGTC_1534 6-azauridine 81.6 µM 1.13816211584827 0.14633564420149 no 485 0.127526397279914 729 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3138 9097216 49.47 µM 1.13807483357431 0.1463543765271 no 486 0.127544617865489 655 25237486
SGTC_1622 st003707 19.4 µM 1.13763716834425 0.14644833153293 no 487 0.127636009836757 711 10140899
SGTC_760 0568-0725 82.9 µM 1.13742990467737 0.146492839617307 no 488 0.127679305909398 719 3916171
SGTC_1129 3453-1384 223 µM 1.13674936659923 0.146639043144787 no 489 0.127821537810141 715 1084452
SGTC_1337 1486-1011 40.3 µM 1.13672906756946 0.1466434055941 no 490 0.127825781981232 663 X1337
SGTC_954 1189-0853 2.85 µM 1.13457950630592 0.147105859144078 no 491 0.128275771922456 695 2828194
SGTC_1801 st050089 28.441 µM 1.13232127753675 0.147592743384127 no 492 0.128749693891726 777 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1613 st002381 52.1 µM 1.12926222308985 0.148254008904378 no 493 0.12939361597307 669 551167
SGTC_2235 salicylic acid 500 µM 1.12212045648635 0.149805525308128 no 494 0.130905613598956 683 338 A COX inhibitor and kinase inhibitor.
SGTC_2000 st075254 36.4 µM 1.11876597185511 0.150537996842403 no 495 0.131619996085185 650 17234175
SGTC_3240 9133527 49.47 µM 1.11587184101062 0.151171861199201 no 496 0.132238498380331 676 17617455
SGTC_3290 9121031 71.43 µM 1.10784432075779 0.152939306741181 no 497 0.133964527692043 636 17014854
SGTC_2743 auranofin 4.32 µM 1.10477596592099 0.153618481340215 no 498 0.134628338579705 675 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_273 hydroxyurea 18.1 mM 1.10364727084933 0.153868817549044 no 499 0.134873088576892 776 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1429 4049-0205 9.46 µM 1.10288578343778 0.154037862254856 no 500 0.135038384377224 760 22774478
SGTC_1671 st016596 74.5 µM 1.09681332623391 0.155390299301565 no 501 0.13636150175437 750 2829167
SGTC_2648 atorvastatin 78.68 µM 1.09507566670793 0.155778742478197 no 502 0.13674174406504 693 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_584 0986-0246 15.4 µM 1.09369883149146 0.156086979843165 no 503 0.137043543471595 774 53315 YDR232W HEM1
SGTC_3339 9145883 14.936 µM 1.0935114245506 0.156128966406876 no 504 0.137084657845313 684 2030670
SGTC_3023 9089636 49.47 µM 1.0921462463855 0.156435044829071 no 505 0.137384412485221 757 17249241
SGTC_2255 7941087 197.44 µM 1.09047599541402 0.156810058908563 no 506 0.137751760873319 802 935561
SGTC_1041 0206-0046 107 µM 1.08958834950558 0.157009598670341 no 507 0.137947258710467 706 50494
SGTC_1614 st002383 48.6 µM 1.08802017827613 0.157362526202269 no 508 0.138293099844932 716 1947235
SGTC_1992 st073643 23.3 µM 1.08727850255934 0.157529626836005 no 509 0.138456873125432 695 3161292
SGTC_1775 st081588 35.1725 µM 1.08698146870469 0.157596581689843 no 510 0.138522499770328 752 1426443 YGL099W LSG1
SGTC_2352 9027995 87.8 µM 1.08397953593162 0.158274301161357 no 511 0.139186936189369 659 2997347
SGTC_990 3985-0011 41.3 µM 1.08019647416879 0.159131088627654 no 512 0.140027349068868 661 5399565 YGL099W LSG1
SGTC_2657 nystatin 74.44 µM 1.07867211296507 0.159477182979446 no 513 0.140366960802172 755 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3301 9125354 19.7965 µM 1.0776235687861 0.159715532604779 no 514 0.140600889901634 654 41905162
SGTC_1522 st012842 45.6 µM 1.07698754935961 0.159860222756114 no 515 0.140742914027464 660 3491067 YOR116C RPO31
SGTC_920 mycophenolic acid 780.421 nM 1.07656715956989 0.159955905663413 no 516 0.140836841140105 711 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2040 5100729 123 µM 1.07452886054213 0.160420364096638 no 517 0.141292858401201 735 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_612 0302-0167 22.4 µM 1.07428488346015 0.160476017097298 no 518 0.141347509028795 796 235821
SGTC_823 0417-1665 178 µM 1.0718967890278 0.161021425245895 no 519 0.141883196304339 735 3429856
SGTC_1097 itavastatin 7.23 µM 1.06697063914924 0.162150307620115 no 520 0.142992547241409 755 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2858 9025781 8.96 µM 1.06423593607164 0.162779214666313 no 521 0.143610915687413 834 4894980 YPL153C RAD53
SGTC_1741 st038134 10.228 µM 1.06282967410333 0.163103233328832 no 522 0.143929599950123 786 1272587
SGTC_368 fentichlor 4.58 µM 1.06053383602059 0.16363312058588 no 523 0.144450902536784 646 7329 A pesticide.
SGTC_1050 3232-1156 69.3 µM 1.05792906888755 0.164235661584304 no 524 0.145043890691864 726 700529
SGTC_2639 lactacystin 53 µM 1.05739425428913 0.164359553994206 no 525 0.145165846349276 771 3870 A proteasome inhibitor.
SGTC_2922 7999257 32.47 µM 1.05726352077498 0.164389848263908 no 526 0.145195668465901 673 2988377
SGTC_2779 methotrexate 400 µM 1.05694479120512 0.164463721155513 no 527 0.145268392350635 778 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1792 st045773 43.6 µM 1.05470501517048 0.164983447424407 no 528 0.145780128691421 727 2919270
SGTC_3082 9117008 49.47 µM 1.05170245336949 0.165681839987698 no 529 0.146468042527483 756 41448529
SGTC_432 NS 1619 61.3 µM 1.04823458881898 0.166490836814157 no 530 0.147265269044655 688 4552 A K+/calcium channel activator.
SGTC_345 1362-0200 395 µM 1.04755352893059 0.16665001617954 no 531 0.147422178784329 708 1419823
SGTC_914 3820-6779 408 µM 1.04672264220558 0.16684434648052 no 532 0.14761375885759 724 2893481
SGTC_2038 4100038 30.985 µM 1.04553592534928 0.167122152799711 no 533 0.147887672822955 760 3596803
SGTC_420 mitomycin C 81.9 mM 1.04473822623808 0.167309058922533 no 534 0.148071986152691 754 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2257 7960413 200 µM 1.04397840987283 0.167487214096472 no 535 0.148247689333761 809 2974689 YIL048W NEO1
SGTC_1583 clindamycin 39.6 µM 1.0433895798656 0.167625361894701 no 536 0.148383948793034 678 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2607 solasodine 47.35 µM 1.0420767981929 0.16793362306433 no 537 0.148688037300047 766 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_874 0599-0792 117 µM 1.04166386062553 0.168030662500782 no 538 0.148783774887881 833 765305
SGTC_953 1188-0045 9.7 µM 1.04121934842643 0.168135162230564 no 539 0.148886878936468 769 6144426
SGTC_2363 9053361 176 µM 1.04114228067888 0.168153284228344 no 540 0.148904759559171 764 6469797 YMR079W SEC14
SGTC_1530 rhein 70.4 µM 1.03879944423797 0.168704787269359 no 541 0.149449009949108 809 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_588 3970-1144 52.9 µM 1.0384784793802 0.168780432744603 no 542 0.149523674666796 776 1888707
SGTC_657 3534-0529 86.7 µM 1.03729378517991 0.169059831896573 no 543 0.149799480639474 787 1049549
SGTC_2088 5278280 127.392 µM 1.03624081484034 0.169308414385266 no 544 0.150044904951223 794 791502
SGTC_501 nsc-95397 161 µM 1.03532351472325 0.169525159327182 no 545 0.150258925883171 748 262093
SGTC_178 4092-0806 87.505 µM 1.03506234963442 0.169586901459966 no 546 0.150319897105953 813 2169044
SGTC_264 promethazine 12.5 mM 1.03276037174004 0.170131736740419 no 547 0.150858026541419 899 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1895 st058434 18.3 µM 1.03001790150287 0.170782290862159 no 548 0.151500801097962 803 5393175
SGTC_2864 9034755 47.6 µM 1.0277727630611 0.171316054134014 no 549 0.152028365602681 788 4930451
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.02707525481408 0.171482097903924 no 550 0.152192514800681 766 6312947
SGTC_1197 1601-0112 267 µM 1.02282166243226 0.172496902312292 no 551 0.153196086891117 790 7350313
SGTC_2513 baicalein 25.65 µM 1.02222470719676 0.172639627267929 no 552 0.153337279752062 761 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2368 9071271 200 µM 1.01912365676295 0.173382262823705 no 553 0.154072132233357 750 27209959
SGTC_1170 0310-0127 64.8 µM 1.01851069023736 0.173529295620373 no 554 0.15421766155328 801 774975
SGTC_125 0133-0007 11.75 µM 1.01789325209754 0.173677481224139 no 555 0.154364344396286 856 26541
SGTC_1985 st071382 65.5 µM 1.01755577116559 0.173758510911782 no 556 0.154444557660224 798 6123237
SGTC_3170 9103054 49.47 µM 1.01748830291242 0.173774713026364 no 557 0.154460596978222 732 16432970
SGTC_747 3448-8087 38.7 µM 1.01642843894821 0.17402935939771 no 558 0.154712704368219 798 5168703
SGTC_2268 7933382 153.85 µM 1.01543287237997 0.174268773433484 no 559 0.154949764993188 864 935025 YOR257W CDC31
SGTC_2885 9057732 51.95 µM 1.01506444785649 0.174357425263416 no 560 0.155037553660263 754 6471414
SGTC_650 1328-0195 38 µM 1.01271646692552 0.174923079097403 no 561 0.155597805055439 796 2780821
SGTC_2335 9018011 154.17 µM 1.0126076430654 0.174949324141085 no 562 0.155623803841863 825 6458208
SGTC_2376 9072922 81.32 µM 1.01079600155509 0.175386604604544 no 563 0.156057038625447 799 17087968
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.01048345857111 0.175462113912418 no 564 0.156131860265104 810 16623 A steroid.
SGTC_817 1391-0715 46 µM 1.00758205610705 0.17616406605172 no 565 0.156827573410415 758 1353946
SGTC_977 1348-1378 135 µM 1.00707116982864 0.176287851355616 no 566 0.156950287237145 819 X977
SGTC_136 0097-0015 404.482 µM 1.00588308656654 0.176575931022924 no 567 0.157235906577408 866 4861337
SGTC_123 0083-0120 66.675 µM 1.00364339590001 0.177119807563907 no 568 0.157775264782341 781 16001701
SGTC_1662 st014054 52 µM 1.00121274767452 0.177711251442673 no 569 0.15836198243801 776 2838777
SGTC_2908 7930301 100 µM 1.00100127879341 0.177762766518889 no 570 0.15841309507134 872 2223178
SGTC_2654 protoveratrine a 100 µM 0.999851230292411 0.17804309007428 no 571 0.158691254523088 791 5702278 A heart drug and vasodilator.
SGTC_1371 2421-0008 32.7 µM 0.999405998550096 0.178151689810977 no 572 0.158799027580853 766 2827552
SGTC_572 0960-0087 17.7 µM 0.99705690709197 0.178725365031726 no 573 0.159368444203737 868 6796365
SGTC_347 4534-1311 26.2 µM 0.996168301978343 0.178942675501033 no 574 0.159584188969713 787 2862016
SGTC_1700 st030840 7.9285 µM 0.993214409936016 0.179666251161506 no 575 0.160302738710873 839 5499307
SGTC_2065 5221596 34.26 µM 0.992081838889495 0.179944168939442 no 576 0.160578802485409 771 788581
SGTC_1957 st077035 62.4 µM 0.990871695427718 0.180241420119731 no 577 0.160874117481749 835 705593
SGTC_1191 1487-1166 10.6 µM 0.990817166415764 0.180254821496997 no 578 0.160887432705361 899 3955771
SGTC_148 3253-0744 288.01 µM 0.98922292740484 0.180646907616643 no 579 0.161277041603346 811 6893655
SGTC_2645 abamectin 100 µM 0.989125647155788 0.180670849958414 no 580 0.161300835391861 798 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_956 1185-0240 191 µM 0.987254185711276 0.181131836069349 no 581 0.161759022087588 779 1416193
SGTC_1547 harmine 94.2 µM 0.986137352216423 0.181407289846423 no 582 0.162032858233132 881 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_466 geldanamycin 89.2 µM 0.984727518640588 0.181755382891634 no 583 0.162378965887718 715 5288382 HSP90 inhibitor.
SGTC_3352 9151559 45.5865 µM 0.983858203372829 0.181970228122013 no 584 0.162592618438462 784 17159339
SGTC_3256 9138902 49.47 µM 0.983628191106289 0.182027100613481 no 585 0.162649179385644 844 17228773
SGTC_1694 st024011 44.9 µM 0.9836138838523 0.182030638570964 no 586 0.162652698020097 863 2787533
SGTC_2870 9038528 12.99 µM 0.983123542388563 0.182151918241168 no 587 0.162773319390185 716 6463316
SGTC_1484 3473-2379 286 µM 0.981527501639597 0.182547028100138 no 588 0.163166339608678 958 671917
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.977351568272788 0.183583336449697 no 589 0.164197565654533 833 4213774
SGTC_506 n9-isopropylolomoucine 153 µM 0.977099075144907 0.183646112991021 no 590 0.164260052798185 841 6610355
SGTC_2495 cafestol 54.53 µM 0.973606826915692 0.184515750690098 no 591 0.16512589766255 767 16667697 An anti-infammatory.
SGTC_512 prima-1 270 µM 0.971053194757953 0.185153273134838 no 592 0.165760894886567 862 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1848 st056003 16.4 µM 0.970336736881173 0.185332384619344 no 593 0.165939335627495 882 146492
SGTC_973 1325-0077 65.9 µM 0.969910785156003 0.185438921749205 no 594 0.166045481831746 902 2835149
SGTC_2750 bromebric acid 70.15 µM 0.969861335419953 0.185451292357129 no 595 0.166057807435467 885 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.969534303803103 0.185533117214109 no 596 0.16613933664781 753 6857784
SGTC_1367 1812-0510 76.9 µM 0.969236240502593 0.18560771357473 no 597 0.16621366655911 820 1142582 YDR527W RBA50
SGTC_1822 st052468 42 µM 0.964767189769479 0.186728414228643 no 598 0.167330716552984 814 2873678
SGTC_2985 9022375 71.43 µM 0.964563971090444 0.186779474602278 no 599 0.167381626293017 836 4939335
SGTC_2950 9072895 21.46 µM 0.96284772183029 0.187211041031615 no 600 0.167811974000851 833 17332245
SGTC_632 0781-2353 4.65 µM 0.962822337642947 0.187217428739631 no 601 0.167818344400801 845 6811515 YHR007C ERG11
SGTC_2765 myclobutanil 7.74 µM 0.962432252681313 0.187315607146106 no 602 0.167916259461705 822 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2778 tioconazole 65.09 nM 0.962170870665357 0.187381410800295 no 603 0.167981889422995 807 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1744 st037937 38.9 µM 0.961594663378512 0.187526523062036 no 604 0.168126626626143 818 1016152
SGTC_906 1165-0455 526 µM 0.960907849721069 0.187699581167294 no 605 0.168299251777864 820 3252859
SGTC_2127 5253358 187.912 µM 0.95888508570279 0.188209834810365 no 606 0.168808319481124 748 20612
SGTC_552 k242-0005 476 µM 0.957895851896697 0.188459685972621 no 607 0.169057639186038 830 4088318
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.957789832675103 0.188486475418954 no 608 0.169084373567306 861 688669
SGTC_1232 0279-0259 161 µM 0.95529672038858 0.189117123779635 no 609 0.169713832773618 839 1560000
SGTC_1850 st056238 17 µM 0.951046866859349 0.190195142136734 no 610 0.170790292561382 899 5393177
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.949848757811372 0.190499735530096 no 611 0.171094553516622 843 390807
SGTC_2504 purpurogallin 52.29 µM 0.949179707038603 0.190669957514957 no 612 0.171264610363907 814 5281571 An antioxidant.
SGTC_2664 lyso-paf C-16 73.48 µM 0.948974190821318 0.190722264329343 no 613 0.171316869403695 897 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2759 disulfiram 3.38 µM 0.94752813583279 0.191090554912438 no 614 0.17168486307985 810 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2459 5811157 9.22 µM 0.946994620091546 0.191226544189886 no 615 0.171820760179945 886 2870684 YBR192W RIM2
SGTC_1159 4092-0538 61.2 µM 0.946741893299613 0.191290983111599 no 616 0.171885158706303 900 717301
SGTC_2830 7992007 71.43 µM 0.946458638170245 0.191363221801489 no 617 0.171957354619734 802 1952075
SGTC_293 4049-0273 38.5 µM 0.946246458725664 0.19141734497654 no 618 0.172011447482312 805 1380311
SGTC_3074 9116018 49.47 µM 0.944806038992141 0.191785018180422 no 619 0.172378954107313 822 17027303
SGTC_2175 5807670 165.306 µM 0.944735110749426 0.191803134076648 no 620 0.172397063567195 850 241186
SGTC_118 0083-0097 135.343 µM 0.94462481210703 0.191831307711171 no 621 0.172425227522224 1038 5207356
SGTC_2923 7992654 58.14 µM 0.944077626712394 0.191971112994402 no 622 0.172564990717409 833 2985126
SGTC_268 camptothecin 39.6153 µM 0.94364782063684 0.192080971704329 no 623 0.172674823292893 944 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3316 9136639 10.545 µM 0.940671974044923 0.192842654762918 no 624 0.17343649271742 863 4903665
SGTC_38 0929-0051 58.268 µM 0.939844123876435 0.193054874814069 no 625 0.173648761018628 913 1379719
SGTC_3060 1327-0027 12.5 µM 0.939333829324613 0.193185760242071 no 626 0.173779687486891 827 16000455 YPR107C YTH1
SGTC_1939 st074455 53.6 µM 0.937404058316417 0.193681216669039 no 627 0.174275377093224 878 1644229
SGTC_1425 4048-4433 7.33 µM 0.935997736040458 0.194042768554842 no 628 0.174637176680488 923 23734946
SGTC_1152 3909-8331 15.9 µM 0.935470946351161 0.194178306897138 no 629 0.174772824706111 833 16001939
SGTC_3283 9109332 35.8195 µM 0.933516365576998 0.194681706991403 no 630 0.175276712323462 786 17027281
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.932499929685491 0.194943802439713 no 631 0.175539111500992 950 6708784 An antioxidant flavonoid
SGTC_3158 9100007 49.47 µM 0.932364477563774 0.194978745956431 no 632 0.175574098089135 808 19297233
SGTC_2748 diazoxide 86.69 µM 0.932210014886609 0.195018598404296 no 633 0.175614000398751 812 3019 A potassium channel activatior.
SGTC_1374 2889-5571 141 µM 0.931474514572125 0.19520843053686 no 634 0.175804080853443 882 2853281
SGTC_503 tyrphostin 8 294 µM 0.931319725869425 0.195248395694418 no 635 0.17584410056603 868 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2226 7298446 200 µM 0.930104432293849 0.195562347128037 no 636 0.176158508068807 845 3283010
SGTC_978 1416-0512 87.4 µM 0.929054940124936 0.195833712959837 no 637 0.176430307372956 900 6814003
SGTC_1355 1499-0035 1.68 µM 0.928142026828883 0.196069949511973 no 638 0.176666950875583 853 1548538
SGTC_685 1278-0033 54.9 µM 0.926273674759393 0.196553965584364 no 639 0.17715188658399 902 3590572
SGTC_1631 benzylvanillin 81.9 µM 0.925569066399176 0.196736689551775 no 640 0.177334987673612 867 75506
SGTC_371 0195-0006 7.36 µM 0.92554594471183 0.196742687372286 no 641 0.177340998150785 779 3928593
SGTC_1664 st014217 9.02 µM 0.92535264372738 0.196792834438702 no 642 0.177391251728743 975 3982782
SGTC_1931 st074438 57.1 µM 0.924598639647045 0.19698851575507 no 643 0.177587360463407 856 2787313
SGTC_289 k017-0060 526 µM 0.924393505061445 0.19704177324836 no 644 0.177640737533326 872 5512909
SGTC_1399 3562-5772 25 µM 0.923614578454756 0.197244079247539 no 645 0.177843510417422 809 23847490
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.923253408232886 0.19733792647696 no 646 0.177937581027553 948 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3094 9117742 49.47 µM 0.921845156997827 0.197704107309836 no 647 0.178304674614134 954 17149698
SGTC_2062 5245942 200 µM 0.921762179404143 0.197725696379799 no 648 0.178326319540547 969 1376160
SGTC_1803 st050068 52.4 µM 0.920544249261217 0.19804274074525 no 649 0.17864421034068 1013 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2307 7538926 6.34 µM 0.920197592893317 0.198133036373132 no 650 0.178734755990814 888 96582
SGTC_2776 terbinafine 19.92 µM 0.920156357949058 0.198143778736118 no 651 0.178745528362641 871 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2595 hexamethylquercetagetin 100 µM 0.919857191643394 0.198221726877004 no 652 0.178823695932854 827 386331
SGTC_1254 0550-0035 264 µM 0.918997871735868 0.198445726634857 no 653 0.179048342698973 931 15121435
SGTC_3166 9102297 49.47 µM 0.917975720768407 0.198712370505763 no 654 0.179315788501938 873 25237072
SGTC_2583 asiatic acid 100 µM 0.916955027820084 0.198978849488149 no 655 0.17958310334204 866 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.913733359979017 0.199821362876323 no 656 0.180428485148715 846 689007
SGTC_902 1120-0002 2.07 µM 0.913353738972643 0.199920780456235 no 657 0.180528263771597 892 3280475
SGTC_583 1488-1091 88.9 µM 0.912733066866816 0.200083390099232 no 658 0.180691474188388 1053 4303273
SGTC_2549 cedrol 20.94 µM 0.911516862676052 0.200402253404145 no 659 0.181011552423047 878 6708665 A sedative which affects the nervous system.
SGTC_1210 3013-0140 750 nM 0.911094630496926 0.200513025194626 no 660 0.181122757688724 960 905973
SGTC_1898 st060199 18.6 µM 0.910751378113417 0.200603103880544 no 661 0.181213193207282 879 688866
SGTC_3243 9134147 49.47 µM 0.910372957136644 0.200702439908015 no 662 0.181312927243626 948 24282180
SGTC_1048 3161-0300 24.5 µM 0.908306866070199 0.201245312169771 no 663 0.181858057967339 936 2165101
SGTC_1770 st043884 66.3 µM 0.907096779991258 0.201563674699947 no 664 0.182177810362757 936 670149
SGTC_2662 daunorubicin 22.37 µM 0.906612996422531 0.201691038096656 no 665 0.182305743300864 867 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_326 k292-0812 17.5 µM 0.905078561781603 0.202095320177574 no 666 0.182711884321805 903 3579357
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.900580643808279 0.203283190999217 no 667 0.183905664965036 902 756377
SGTC_235 0330-0087 5 mM 0.899859826460173 0.20347394079984 no 668 0.184097425810804 946 46494818 YHR062C RPP1
SGTC_2083 5306046 65.942 µM 0.899813537531602 0.203486193880323 no 669 0.184109744422299 899 539837
SGTC_459 nigericin 15.3 µM 0.899360587072691 0.203606117015948 no 670 0.184230312648001 968 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3276 9139060 49.47 µM 0.898759716230684 0.203765268567473 no 671 0.184390330741317 891 4870619
SGTC_1504 k297-0033 30 µM 0.898103375875226 0.203939196945099 no 672 0.184565219714005 789 4388117
SGTC_2935 9038016 29.96 µM 0.897223222308778 0.204172574013827 no 673 0.184799907992905 942 6463195
SGTC_1695 st026914 34.495 µM 0.894390563003954 0.204924746579799 no 674 0.185556479944132 907 3289191
SGTC_635 k038-0028 24.7 µM 0.894076936048718 0.205008126958992 no 675 0.185640364264024 919 4035102
SGTC_1461 k072-0203 53.8 µM 0.893089384808592 0.205270807506308 no 676 0.185904653583575 876 5418714
SGTC_794 k038-0031 316 µM 0.892262456175118 0.205490917493548 no 677 0.186126136333303 967 6624242
SGTC_1437 4092-1038 11.6 µM 0.891396455199728 0.20572157783614 no 678 0.186358259380348 963 3977136
SGTC_2020 4017018 200 µM 0.891321305275271 0.205741601346721 no 679 0.186378411031963 907 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_64 000l-0018 272.079 µM 0.888778848960292 0.206419713746005 no 680 0.187060972637012 956 6811119
SGTC_1685 st024049 53.0905 µM 0.886044681151977 0.207150434369026 no 681 0.187796725276025 913 1941139
SGTC_2147 5545932 89.7195 µM 0.885810918722183 0.20721297951989 no 682 0.187859712554391 906 797404
SGTC_2927 9011802 47.9 µM 0.885205242591882 0.207375085332725 no 683 0.188022972646759 878 43912568
SGTC_442 cape 100 µM 0.884689551009911 0.207513166362896 no 684 0.188162046400417 905 5281787
SGTC_1804 st050076 49.1 µM 0.884506630780614 0.207562157941819 no 685 0.188211392302648 925 3895976
SGTC_2185 6113692 200 µM 0.882932144849572 0.207984135515817 no 686 0.188636467280128 855 874150
SGTC_2837 9008476 45.46 µM 0.88228602954076 0.208157447175555 no 687 0.188811074683955 926 2992805
SGTC_2717 st081029 62.2815 µM 0.881357462394931 0.208406671905466 no 688 0.189062186760008 923 5292846
SGTC_3017 9080681 49.47 µM 0.881170417232559 0.208456895572108 no 689 0.189112794194811 912 16451914
SGTC_1612 st002233 45.4 µM 0.880559876530395 0.208620882076808 no 690 0.189278041756173 917 1035021
SGTC_137 0438-0332 85.389 µM 0.879184703885534 0.208990521228195 no 691 0.189650568334907 1020 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.878006563947518 0.209307505617941 no 692 0.189970078298944 916 4330530
SGTC_1851 st056236 18.9 µM 0.876255741849199 0.209779095335297 no 693 0.190445509714318 983 5393171
SGTC_246 cycloheximide 667 µM 0.872686019679752 0.210742544744705 no 694 0.1914171199474 844 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_676 falcarinol 140 µM 0.872097968045194 0.21090150544847 no 695 0.191577467285557 989 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1203 3992-3522 103 µM 0.871447244984762 0.211077489260191 no 696 0.191754999462159 988 5322312
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.871200348117701 0.211144283426353 no 697 0.19182238494416 936 616764
SGTC_3072 9116419 49.47 µM 0.870298925534876 0.211388254646011 no 698 0.192068532987371 905 17170162
SGTC_3026 9090633 49.47 µM 0.869739825004999 0.211539658873764 no 699 0.192221301517783 973 25236842
SGTC_3043 9092303 49.47 µM 0.869567290808659 0.211586393890126 no 700 0.192268459734787 921 25236084
SGTC_3194 9111903 49.47 µM 0.86952771874364 0.211597113783123 no 701 0.192279276837604 928 17087251
SGTC_1112 tnp00069 1.16933 µM 0.867212046324269 0.212224972431605 no 702 0.19291291854961 986 145826
SGTC_726 3448-4391 34.2 µM 0.86692310922314 0.212303389588657 no 703 0.192992070339106 989 1356692
SGTC_3287 9117173 37.0625 µM 0.86615204616163 0.21251273798528 no 704 0.193203393374446 945 2789709
SGTC_1150 3909-7983 10.9 µM 0.862641172301495 0.213467485333984 no 705 0.194167392932731 949 23965914
SGTC_861 0443-0273 110 µM 0.862466009976408 0.213515184375585 no 706 0.194215564802387 972 6149169
SGTC_232 clozapine 119 µM 0.861429053442323 0.213797688692327 no 707 0.194500890114082 944 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3303 9125618 40.5795 µM 0.861335399909038 0.213823214002062 no 708 0.194526672046515 994 22695467
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.861205362856615 0.21385865859773 no 709 0.194562473466613 905 75037 A free radical scavenger.
SGTC_575 k072-0246 11.9 µM 0.860763985796637 0.213978991599056 no 710 0.194684022005669 982 6796779
SGTC_160 3453-0671 289.699 µM 0.860639415102203 0.214012960543297 no 711 0.194718335240661 1013 5322268
SGTC_2121 5257820 149.641 µM 0.859741269863661 0.214257966931237 no 712 0.194965839931867 1014 791256
SGTC_225 nsc-122657 1.016 µM 0.859502391383104 0.214323158410243 no 713 0.195031700611313 841 275685
SGTC_1403 3909-7815 62.9 µM 0.857749915188682 0.214801773140826 no 714 0.195515285578314 928 6615483
SGTC_139 0099-0334 718.624 µM 0.857471623717587 0.214877833774926 no 715 0.195592145331324 1075 97690
SGTC_3227 9130768 49.47 µM 0.857225532960443 0.214945106572357 no 716 0.195660127032806 988 17720899
SGTC_2852 9023854 51.95 µM 0.85591981892689 0.215302248705941 no 717 0.196021065825836 948 19798528
SGTC_325 2810-4341 181 µM 0.855668626131683 0.215370995054429 no 718 0.196090549397321 983 774970
SGTC_1385 3091-4834 14.1 µM 0.852711500821323 0.216181256931555 no 719 0.196909655750269 921 4072814
SGTC_948 3448-0295 75.3 µM 0.851724556438549 0.216452075253653 no 720 0.19718349393345 986 678569
SGTC_296 1222-0039 74.9 µM 0.850971501901812 0.216658846003103 no 721 0.197392591794701 939 5984176
SGTC_2445 5742597 35.57 µM 0.850529431814577 0.216780281067243 no 722 0.197515402197323 923 1774255
SGTC_1173 0443-0020 122 µM 0.848923865732005 0.217221655204636 no 723 0.197961828986527 967 5331295
SGTC_1952 st077036 64.1 µM 0.848064029191051 0.217458239693751 no 724 0.198201156454081 1027 2937007
SGTC_1712 st032288 53.4 µM 0.84804520806921 0.217463419998726 no 725 0.198206397090212 1036 2883011
SGTC_1383 3049-0032 20.7 µM 0.846381178327791 0.217921707233264 no 726 0.198670067432974 1014 712864
SGTC_1655 st012546 55.1 µM 0.84555080674073 0.218150606416553 no 727 0.198901689153099 926 720985 YLR208W SEC13
SGTC_2184 6075246 200 µM 0.844119875998752 0.218545379934303 no 728 0.199301210998436 952 2267320
SGTC_1681 tripelennamine 100 µM 0.843425511427112 0.218737093414288 no 729 0.199495254510639 938 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_925 2064-1272 59.6 µM 0.842083516593106 0.21910789123383 no 730 0.199870603536097 912 6815817
SGTC_3269 9137823 49.47 µM 0.84137617440566 0.219303477693402 no 731 0.200068614309896 907 17682936
SGTC_2647 atorvastatin 60.16 µM 0.840900485148038 0.219435066450103 no 732 0.200201843308288 965 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2817 7995342 71.43 µM 0.838145793238038 0.220197981571208 no 733 0.200974413377215 948 18879975
SGTC_1319 1306-0155 43.7 µM 0.836351527402521 0.22069572254294 no 734 0.201478586637324 1006 3122360
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.835283194286851 0.220992390898003 no 735 0.201779138701983 1014 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_491 tetrandrine 80.3 µM 0.834850621160344 0.221112578207394 no 736 0.201900909976366 964 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2441 5730946 39.09 µM 0.833549733369185 0.221474245734798 no 737 0.202267380724528 985 1774275
SGTC_863 0466-0191 129 µM 0.833447294067253 0.221502739849321 no 738 0.202296255604943 1031 765160 YPR165W RHO1
SGTC_2296 7971656 126.45 µM 0.832198516684812 0.221850263311456 no 739 0.202648450502506 982 666570
SGTC_2290 7904846 200 µM 0.831877489878866 0.221939652463733 no 740 0.20273904943889 978 2962154
SGTC_2600 tangeritin 87.95 µM 0.831632555388569 0.222007867721335 no 741 0.202808190172534 944 68077 A bioactive flavone.
SGTC_1366 1683-0113 21.9 µM 0.830147196249989 0.222421802641198 no 742 0.203227782802367 997 708623
SGTC_561 1550-0330 72.9 µM 0.830129964640044 0.222426607270174 no 743 0.203232653523097 967 6812934
SGTC_1902 st060212 70.5 µM 0.8291162861405 0.222709351814186 no 744 0.203519304469413 1055 688944
SGTC_1527 coumarin 137 µM 0.827985609128194 0.223024972205688 no 745 0.203839324942428 947 323 A hepatotoxic, DNA x-linker.
SGTC_729 4092-0585 94.1 µM 0.824740131119775 0.223932337768466 no 746 0.204759571338022 973 2169061
SGTC_60 0986-0278 202 µM 0.82380025884011 0.224195496927262 no 747 0.205026530253292 905 3110598
SGTC_2952 9073731 13.78 µM 0.823522538601987 0.22427329069254 no 748 0.205105452779091 1069 16457353
SGTC_1335 1486-0900 202 µM 0.823398810391331 0.224307953826138 no 749 0.205140619669825 1049 X1335
SGTC_2949 9072542 2.23 µM 0.822328854494314 0.22460783465372 no 750 0.205444879401423 1042 16457352
SGTC_495 decylubiquinone 155 µM 0.822134326533367 0.224662380207999 no 751 0.205500225434283 941 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3161 9100388 49.47 µM 0.81791410058041 0.225847577797027 no 752 0.206703119095324 1051 25236368
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.817868325861714 0.225860452407926 no 753 0.206716189106642 1083 1273210
SGTC_2489 cantharidin 73.42 µM 0.816844944394051 0.226148397325777 no 754 0.207008521972747 1017 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3115 9123671 49.47 µM 0.814986650664527 0.226671788279955 no 755 0.207539975693098 1101 3286988
SGTC_3071 9117417 49.47 µM 0.81365715673332 0.227046661174634 no 756 0.207920692194185 938 45595590 YGL055W OLE1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.81313409073223 0.227194244084403 no 757 0.208070591368342 981 6708760
SGTC_3054 9094397 49.47 µM 0.811249518930165 0.227726423535369 no 758 0.208611196737629 1071 2598354
SGTC_2357 9067248 200 µM 0.809712498210893 0.228160977914975 no 759 0.209052716563248 981 9150235
SGTC_1986 st071812 45 µM 0.808516573238064 0.228499418225965 no 760 0.209396634640349 987 11838594
SGTC_564 3555-0129 330 µM 0.808248873662229 0.228575214372435 no 761 0.209473663913317 934 563260
SGTC_1014 4130-3005 69.3 µM 0.807983792571532 0.228650283037309 no 762 0.209549956154411 1036 743608
SGTC_497 capsazepine 133 µM 0.807763110052629 0.228712788971119 no 763 0.20961348263347 1045 2733484 A calcium channel blocker.
SGTC_1721 st082152 9.2685 µM 0.804158911761026 0.22973499595744 no 764 0.210652602486492 1010 5296051
SGTC_2330 7979373 200 µM 0.803128494234884 0.230027708082305 no 765 0.210950234900396 1008 1863007
SGTC_1705 st027868 56.3335 µM 0.801039188764813 0.230621860087991 no 766 0.211554479532688 1069 292948
SGTC_439 amiodarone 34.4 µM 0.800958968956167 0.230644689898825 no 767 0.211577699955371 1025 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_731 3966-0296 387 µM 0.800482349936809 0.230780357270283 no 768 0.211715692843201 1053 660956
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.798108880413134 0.231456617464985 no 769 0.212403654248544 1079 688761
SGTC_483 fpl-64176 144 µM 0.797851417743568 0.231530041319892 no 770 0.212478359474106 1031 3423
SGTC_2744 captopril 92.04 µM 0.796699101047764 0.231858820963333 no 771 0.212812903082527 1006 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2084 5306078 60.6385 µM 0.792131861216416 0.233164503018307 no 772 0.214141897015527 1012 679340
SGTC_2892 9047358 58.44 µM 0.791774879015988 0.233266728753826 no 773 0.214245976233075 1005 6466771
SGTC_1953 st076800 12.1 µM 0.791549504850565 0.233331279903764 no 774 0.214311699889721 971 297591
SGTC_2937 9044753 11.33 µM 0.78998992314214 0.23377824321985 no 775 0.21476682665593 1102 6465530 YGL099W LSG1
SGTC_2024 5144227 134 µM 0.788883044913492 0.234095753130132 no 776 0.215090183143673 1070 3475211
SGTC_1497 4476-2978 41.3 µM 0.788838883997748 0.234108425716312 no 777 0.215103089898377 1089 1528379
SGTC_1260 0700-1617 7.75 µM 0.788133903063768 0.234310781188154 no 778 0.215309193058558 1034 2853078
SGTC_1966 st070145 16.1 µM 0.785178927698282 0.235160020299355 no 779 0.216174334286962 1049 3748532
SGTC_1588 farnesol 29.9 µM 0.784976005469821 0.235218401027573 no 780 0.216233818499775 1033 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_622 1348-1566 26.3 µM 0.784278040434359 0.235419266670232 no 781 0.216438490906601 1113 7340407
SGTC_1914 st062367 72.6 µM 0.78378036862068 0.235562548213919 no 782 0.216584497446882 1011 978205
SGTC_3231 9132313 49.47 µM 0.783421395956674 0.235665927621532 no 783 0.216689847909777 1050 4905967
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.783078643200766 0.235764659256825 no 784 0.216790465845302 1047 803109
SGTC_868 0527-0199 213 µM 0.778762665897163 0.237009847781189 no 785 0.21805976692538 1036 2849450
SGTC_835 0312-0010 67.2 µM 0.778291832897722 0.23714590459064 no 786 0.218198494565775 1040 1626196
SGTC_192 3455-0609 60.9 µM 0.778261099256293 0.237154787195581 no 787 0.218207551785547 1077 3769639
SGTC_2167 5876490 200 µM 0.777024826592883 0.237512244947637 no 788 0.218572061560269 1082 686534
SGTC_727 3032-0951 202 µM 0.776989925026999 0.237522340729743 no 789 0.218582357225257 1039 3652836
SGTC_708 3448-5400 146 µM 0.776783112629344 0.23758216903602 no 790 0.21864337085181 1089 3462195
SGTC_451 chloral hydrate 100 µM 0.77625305811321 0.237735545100967 no 791 0.218799791862037 1115 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_974 1326-0144 138 µM 0.776158741061144 0.237762842283563 no 792 0.218827631913069 1088 5411856
SGTC_795 0685-0265 78 µM 0.775918256742546 0.237832450885226 no 793 0.21889862613369 1147 302754
SGTC_2971 9092186 9.93 µM 0.775708164162443 0.237893271691278 no 794 0.21896065914529 1005 25236400
SGTC_3184 9108758 49.47 µM 0.77480472134404 0.238154911270164 no 795 0.219227529504981 1059 902885
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.774609487115753 0.238211472362754 no 796 0.219285224817186 1104 688751
SGTC_1360 1598-0022 39.8 µM 0.774198274216581 0.238330628468977 no 797 0.219406774350587 1107 761525
SGTC_2813 7971799 71.43 µM 0.774056270313666 0.238371784157144 no 798 0.219448757968486 1045 2234054
SGTC_2802 7925815 54.55 µM 0.773515047845974 0.238528677377589 no 799 0.219608813327434 1062 1262923
SGTC_652 0437-0092 114 µM 0.773472953203394 0.238540882425412 no 800 0.219621264757241 1068 3091274
SGTC_3022 9087993 49.47 µM 0.773406715676652 0.23856008822615 no 801 0.219640858378152 1084 17173644
SGTC_882 0843-0131 351 µM 0.772444965447265 0.238839046385957 no 802 0.219925465313443 1123 5425421
SGTC_1668 st014914 51.6 µM 0.771625883408102 0.239076763875371 no 803 0.22016801979612 1094 2839556
SGTC_177 1327-0068 8.361 µM 0.771174037277397 0.239207955920826 no 804 0.220301890470455 1062 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3353 9151644 39.2805 µM 0.770557241709755 0.239387103977154 no 805 0.220484706835523 1059 4909158
SGTC_2099 5377090 177.372 µM 0.770103507832493 0.239518937588624 no 806 0.22061924768586 1043 2243829
SGTC_3345 9148410 3.559 µM 0.7678347337412 0.240178730320914 no 807 0.221292688114483 1060 4903596
SGTC_176 1486-1328 72.834 µM 0.767518947174477 0.24027064414854 no 808 0.221386516193682 1103 22310231
SGTC_782 0083-0095 30.5 µM 0.766312982396118 0.240621832327778 no 809 0.221745047708938 1129 3591729 An indicator and reagent.
SGTC_61 0978-8327 98.565 µM 0.765231180843122 0.240937100627227 no 810 0.222066947742039 1147 6150059 YHR072W ERG7
SGTC_2880 9042983 58.44 µM 0.764189460148933 0.241240900424077 no 811 0.222377173303175 1109 6464714
SGTC_412 gemfibrozil 100 µM 0.763657859775619 0.241396012655566 no 812 0.222535579691968 1065 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2602 kawain 100 µM 0.762268282640871 0.241801724159938 no 813 0.222949949930186 1116 5369129
SGTC_355 1311-2252 105 µM 0.760799015658739 0.242231104667804 no 814 0.223388561223153 1069 5338538
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.760374664529816 0.24235519447364 no 815 0.223515331491753 1133 5393153
SGTC_1175 0741-0056 27.6 µM 0.760142607255969 0.242423067800856 no 816 0.223584673373672 1166 765927
SGTC_278 4092-0821 23.9 µM 0.759858731865749 0.242506111164213 no 817 0.223669515851194 1095 877900
SGTC_1074 carmofur 3.8 µM 0.759690847963643 0.24255523025788 no 818 0.223719700304429 1157 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2241 6772625 37.8075 µM 0.75890203791661 0.242786090638019 no 819 0.223955579891845 1100 2285411
SGTC_797 k781-0471 270 µM 0.757668262941508 0.24314741687609 no 820 0.224324801522547 1116 23738129
SGTC_1666 st014829 29 µM 0.757471232020772 0.243205146726867 no 821 0.224383797318093 1132 3858230
SGTC_598 3937-0236 20.2 µM 0.757217135533626 0.243279607666783 no 822 0.224459892916594 1121 1379313
SGTC_1816 st051957 91.6 µM 0.755522292144356 0.243776582994911 no 823 0.224967830952415 1093 674121
SGTC_402 epigallocatechin gallate 10 µM 0.755135425430585 0.243890099871178 no 824 0.225083864673342 1080 65064 An antioxidant.
SGTC_2730 imipramine 71.33 µM 0.753768160443044 0.244291519851153 no 825 0.225494222834961 1152 3696 A tricyclic antidepressant.
SGTC_866 0495-0101 262 µM 0.752703382464128 0.244604378138376 no 826 0.225814088454473 1045 635694
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.751355921815765 0.245000604757838 no 827 0.226219241235872 1169 91467 include heat shock
SGTC_321 4534-3890 65.3 µM 0.750038659776794 0.245388284878589 no 828 0.226615710639736 1140 699746
SGTC_3095 9117207 49.47 µM 0.74903775210383 0.24568307981171 no 829 0.226917225778888 1065 17015229
SGTC_1051 3253-3903 78 µM 0.748905059234756 0.24572217579597 no 830 0.22695721538551 1127 5509239
SGTC_1105 epirubicin 18.1 µM 0.746243435882131 0.246507088645961 no 831 0.227760186874217 1106 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1035 k081-0041 55.2 µM 0.746240280532014 0.246508019955396 no 832 0.227761139743521 1145 731709
SGTC_2057 5236571 38.335 µM 0.744947080116037 0.246889869936627 no 833 0.228151856088108 1126 54684039 YBR257W POP4
SGTC_3109 9122853 49.47 µM 0.744299705043177 0.247081142566586 no 834 0.228347589834299 1156 1234709
SGTC_2467 5474540 200 µM 0.74382239922765 0.247222217498081 no 835 0.228491963587595 1128 5413519
SGTC_1382 3002-2117 298 µM 0.743754412133684 0.24724231561287 no 836 0.22851253225181 1166 1497314
SGTC_3220 9131269 49.47 µM 0.743610839497173 0.247284760940446 no 837 0.228555971815315 1152 17722206
SGTC_3000 9075062 71.4286 µM 0.74351181714624 0.24731403784252 no 838 0.228585934876639 1069 17057871
SGTC_2955 9076254 12.21 µM 0.743216560870106 0.247401344173996 no 839 0.228675289234941 1080 16459619
SGTC_205 1486-1330 71.903 µM 0.742730251419002 0.247545180217231 no 840 0.228822505378795 1081 4118834
SGTC_645 0845-0943 5.41 µM 0.740215702756233 0.248289622004754 no 841 0.229584560483222 1091 1885106
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.738247639215802 0.248873106408279 no 842 0.230181989230813 1115 688667
SGTC_2008 4012253 172 µM 0.737461718029856 0.249106317264782 no 843 0.230420807577385 1138 603940
SGTC_735 3076-0345 636 µM 0.736889571932216 0.249276166516692 no 844 0.230594753049076 1160 2888990
SGTC_1897 st060201 15 µM 0.736807496291359 0.249300536821979 no 845 0.230619711933728 1117 611878
SGTC_1096 rimcazole 32.2 µM 0.736720879276707 0.249326256948165 no 846 0.230646053469565 1048 18528119 A dopamine reuptake inhibitor.
SGTC_175 3793-3120 23.7 µM 0.736213818056311 0.249476852412825 no 847 0.230800292127651 1133 5322297
SGTC_772 k072-0172 35.3 µM 0.735094393668648 0.249809488738627 no 848 0.231141004232605 1092 5861980
SGTC_1784 st039334 36.3 µM 0.734454496303154 0.249999739598375 no 849 0.231335891741281 1153 3496984
SGTC_1963 st076565 50.3 µM 0.734358665979305 0.250028237975118 no 850 0.23136508576792 1159 4914280
SGTC_3211 9128781 49.47 µM 0.733037564197294 0.250421287728563 no 851 0.231767759373446 1051 17194361
SGTC_1022 4477-0945 21.3 µM 0.731236975026446 0.25095751984206 no 852 0.23231720956186 1112 4648966
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.730895154468784 0.251059385751885 no 853 0.232421597964472 1166 115019
SGTC_12 0849-0099 9.267 µM 0.729440857366494 0.251493025094853 no 854 0.23286601648795 1094 6071388
SGTC_1617 st002906 78 µM 0.729281794947498 0.251540478002555 no 855 0.232914652983763 1143 5150859
SGTC_1665 st014639 11.4 µM 0.729116223651558 0.251589877720523 no 856 0.232965285691321 1218 981133 YIL048W NEO1
SGTC_2115 tiliquinol 12.7705 µM 0.72804344696245 0.251910074646156 no 857 0.233293495399669 1114 71208 A bioactive hydroxyquinoline.
SGTC_343 4130-2827 29.8 µM 0.727385939918932 0.252106430260771 no 858 0.233494782570166 1157 1118244
SGTC_2592 piperlongumine 83.33 µM 0.727004029351236 0.25222051975961 no 859 0.233611743700041 1111 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2063 5246145 200 µM 0.72574050304729 0.252598171417612 no 860 0.23399893343564 1176 711240
SGTC_467 ro 31-8220 72.8 µM 0.724505176911591 0.252967682182825 no 861 0.234377825040741 1115 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_98 0074-0023 107.663 µM 0.724430817385921 0.252989933677598 no 862 0.234400642963458 1153 3563821
SGTC_1861 st057647 17.4 µM 0.717214571459275 0.255154228019269 no 863 0.23662085479054 1172 688668
SGTC_1353 1498-1206 8.11 µM 0.716702269842458 0.255308244640678 no 864 0.236778912516416 1211 6756808
SGTC_589 1227-0070 34.1 µM 0.715554528900412 0.255653473904851 no 865 0.237133229656861 1149 2841384
SGTC_938 3126-1755 342 µM 0.714504850891887 0.255969420093898 no 866 0.237457528826623 1189 1777771
SGTC_1746 st038117 42 µM 0.713427003295926 0.256294057011112 no 867 0.237790784217417 1156 2898218
SGTC_1036 k216-0215 33.5 µM 0.712635173422624 0.256532684924547 no 868 0.238035770286923 1174 622330
SGTC_15 0266-0086 27.098 µM 0.71096033805618 0.25703779869583 no 869 0.238554406934688 1268 1712902 YIL048W NEO1
SGTC_2420 aureobasidin a 50 nM 0.710858399469847 0.257068559057583 no 870 0.238585993628135 1208 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1759 st043059 70 µM 0.710717747903135 0.257111004353594 no 871 0.238629579684781 1180 669426
SGTC_3174 9107204 49.47 µM 0.710316598502868 0.257232081714396 no 872 0.238753914501787 1197 3938802
SGTC_2772 vinpocetine 57.06 µM 0.707895011979434 0.257963608774168 no 873 0.239505228759322 1192 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2116 5511452 16.8835 µM 0.706122775135877 0.258499659571864 no 874 0.240055894726241 1172 870744
SGTC_1169 aniline yellow 25.8 µM 0.705484653923857 0.258692814103298 no 875 0.240254339386047 1144 6051 A DNA damaging agent.
SGTC_270 tamoxifen 5.46 µM 0.704901184250208 0.25886949138717 no 876 0.240435866568904 1270 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2818 7996756 12.99 µM 0.70469100768388 0.258933149103243 no 877 0.240501274313275 1183 2241621
SGTC_2508 celastrol 40.54 µM 0.704537236051608 0.258979728172779 no 878 0.240549134765456 1142 122724 Celastrol is a natural product and antioxidant.
SGTC_2960 9079389 5.97 µM 0.703787761601983 0.259206814008627 no 879 0.240782478184446 1165 16457355
SGTC_3217 9129673 49.47 µM 0.703374018457753 0.259332219540737 no 880 0.240911346849515 1182 17248312
SGTC_450 aminopyrene 156 nM 0.701372521736082 0.259939315454167 no 881 0.24153528286102 1166 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1872 amphotericin b 148 nM 0.70107288278417 0.260030265272734 no 882 0.241628766186386 1199 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_3121 9125696 49.47 µM 0.700631326914178 0.260164321226838 no 883 0.241766561477225 1237 1235365
SGTC_2936 9038235 15.59 µM 0.700611221520919 0.260170426053467 no 884 0.241772836734488 1197 4749415
SGTC_2700 st077718 96.8 µM 0.699927174702006 0.260378174862866 no 885 0.241986392788426 1172 904970
SGTC_2007 4011539 71.82 µM 0.699180496387003 0.260605042711078 no 886 0.24221961883192 1206 45595301
SGTC_918 glabranin 770.725 nM 0.699027340098697 0.260651589697878 no 887 0.24226747247327 1203 124049 Also referred to as licorice root.
SGTC_3070 9117005 49.47 µM 0.698908498682518 0.260687710717936 no 888 0.242304607972234 1203 8779016
SGTC_2795 7780010 54.55 µM 0.698464200604578 0.26082277483678 no 889 0.242443469306347 1171 953673
SGTC_2328 6201408 200 µM 0.698370413244963 0.260851290267963 no 890 0.242472787204481 1152 2890418
SGTC_2768 sulfasalazine 50.2 µM 0.697832555839748 0.261014853246043 no 891 0.242640958335543 1220 5384001 An antioxidant and salicylic acid derivative.
SGTC_1740 st038286 13.222 µM 0.697549509317802 0.261100949149632 no 892 0.242729483455162 1198 716786
SGTC_1128 3448-9350 235 µM 0.696135455976597 0.261531288484511 no 893 0.243172001954725 1162 619386
SGTC_1233 0325-0408 14.2 µM 0.695504158801782 0.261723528866985 no 894 0.243369702910815 1195 12874
SGTC_2428 5615643 7.78 µM 0.695434457223262 0.261744758588597 no 895 0.243391536414413 1200 2253075
SGTC_1567 st069303 68.4 µM 0.695017054428218 0.261871909704904 no 896 0.24352230689477 1231 5581319
SGTC_2619 obliquin 87.91 µM 0.69425789694271 0.262103248844891 no 897 0.243760244883868 1189 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2390 9097792 176.6 µM 0.693736136264941 0.262262306425919 no 898 0.24392384981129 1175 4497149
SGTC_464 bw-b 70c 158 µM 0.693328834570907 0.26238650579632 no 899 0.244051605784226 1215 5353454
SGTC_380 3970-0968 6 µM 0.692809688796834 0.262544853667577 no 900 0.244214495548438 1169 2891601
SGTC_1977 st070720 65.3 µM 0.692733372262561 0.262568135569735 no 901 0.244238445945095 1186 682188
SGTC_117 lucigenin 22.078 µM 0.692551371203198 0.262623662937958 no 902 0.244295568397207 1195 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_97 0535-0701 19.132 µM 0.692455259401316 0.262652988463053 no 903 0.244325736741202 1166 2832013 YGL099W LSG1
SGTC_2979 9012552 45.46 µM 0.689869117266237 0.263442697842974 no 904 0.245138249207377 1240 17100905
SGTC_1570 verbenone 133 µM 0.689640318576352 0.263512622568349 no 905 0.245210202933068 1221 29025 A natural terpanoid with antifungal properties.
SGTC_1965 Pectolinarigenin 58.4 µM 0.689562672181876 0.263536354764147 no 906 0.245234624129733 1208 5320438 An anti-inflammatory.
SGTC_1815 st051655 58.2 µM 0.688816612718048 0.263764439334664 no 907 0.245469339967209 1186 5984156
SGTC_1464 k208-0027 110 µM 0.688364895263102 0.263902586866159 no 908 0.245611512271681 1217 X1464
SGTC_2822 7994718 71.43 µM 0.68710936486602 0.264286755977715 no 909 0.246006906629699 1162 1018011
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.685452230609116 0.264794244037271 no 910 0.246529297330987 1230 229346 A bile salt which induces apoptosis.
SGTC_3187 9109394 49.47 µM 0.68389321529531 0.26527213560835 no 911 0.247021299308623 1169 17098090
SGTC_841 0251-0215 91.2 µM 0.683435482700765 0.265412529425311 no 912 0.247165852587276 1242 3888614
SGTC_1256 0570-0116 285 µM 0.683275443389822 0.265461624904648 no 913 0.247216404136898 1212 410638
SGTC_1980 st071811 45.7 µM 0.681143985280017 0.266115934286949 no 914 0.247890193740618 1260 4974850
SGTC_2990 9074105 71.4286 µM 0.680273033546163 0.266383531585962 no 915 0.248165797994257 1183 6502001
SGTC_3319 9138450 16.7555 µM 0.679688857571564 0.266563094151324 no 916 0.248350746359587 1186 2029690
SGTC_440 fluspirilene 35.1 µM 0.677207452193212 0.267326503968564 no 917 0.249137170088415 1283 3396 An atypical antipsychotic.
SGTC_2451 5856223 45.7 µM 0.676794586554825 0.267453629940582 no 918 0.249268146662323 1202 2179896
SGTC_203 k066-0004 30.888 µM 0.674855057295943 0.268051240557807 no 919 0.249883928264797 1291 6795412
SGTC_613 3914-0030 117 µM 0.674804465047947 0.268066838107355 no 920 0.249900001608454 1038 1145395
SGTC_2173 5763948 167 µM 0.673765389898452 0.26838728516166 no 921 0.250230240952882 1239 2867177
SGTC_674 0498-0004 451 µM 0.673578790920449 0.268444852015192 no 922 0.250289570428081 1203 4231473
SGTC_1564 D-Arginine 115 µM 0.671888160509282 0.268966703964199 no 923 0.250827449090209 1201 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2924 9010168 62.78 µM 0.671883335536825 0.26896819403136 no 924 0.25082898504356 1261 2993929
SGTC_144 4161-2749 112.381 µM 0.670775378420397 0.269310467443309 no 925 0.251181817405542 1166 797501 YMR168C CEP3
SGTC_2699 st077704 54.6 µM 0.669457329381387 0.269717927353511 no 926 0.251601895815632 1236 645852
SGTC_2661 dactinomycin 12.96 µM 0.667463128360748 0.270334998389219 no 927 0.252238177009621 1250 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2202 7226349 200 µM 0.667158786383989 0.270429233786582 no 928 0.252335356676436 1197 844334
SGTC_883 0850-0245 24.6 µM 0.666456370464365 0.270646790072167 no 929 0.252559720958184 1285 6823229 YPR165W RHO1
SGTC_1224 0823-0416 294 µM 0.66579308904681 0.270852305602896 no 930 0.252771681416479 1272 3598164
SGTC_2161 5662504 8.5105 µM 0.66474995041693 0.271175676112302 no 931 0.25310521971762 1221 2859334
SGTC_2196 6573537 42.6665 µM 0.663966143134545 0.271418781111458 no 932 0.253355990379104 1287 2903087
SGTC_1284 0929-0043 16 µM 0.662795702755092 0.271782005920167 no 933 0.253730703101974 1228 1239883
SGTC_1449 4112-4002 201 µM 0.660338573192705 0.272545317342185 no 934 0.254518290927836 1214 2059539
SGTC_1876 myriocin 605 nM 0.660111292138911 0.272615976324169 no 935 0.254591206363843 1294 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_11 0438-0307 1.3 µM 0.658141122513105 0.273228859441995 no 936 0.255223726856308 1257 4011476
SGTC_2742 clothiapine 36.27 µM 0.658128166248445 0.27323289215303 no 937 0.255227889166648 1210 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2178 5812956 200 µM 0.657944799045538 0.273289969399003 no 938 0.255286801247377 1248 5403383
SGTC_2336 9001819 198.65 µM 0.657096821163944 0.273553998736578 no 939 0.255559331382161 1319 2989602
SGTC_2651 TUB2.036 5 µM 0.65606575430727 0.273875205269952 no 940 0.25589090878538 1343 15992207 YFL037W TUB2
SGTC_2237 6667747 47.222 µM 0.652564064440475 0.274967470909845 no 941 0.257018679477594 1233 729940 YDL015C TSC13
SGTC_1923 st058458 19.1 µM 0.650276519900747 0.275682171072389 no 942 0.257756810547726 1326 3534982
SGTC_1072 oxiconazole 14.9 nM 0.648660529375312 0.276187606662497 no 943 0.258278911047537 1291 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_151 3013-0144 2.285 µM 0.648261383129529 0.276312518190056 no 944 0.258407953125583 1250 906558 YHR107C CDC12
SGTC_2199 6590217 200 µM 0.647535333388095 0.276539804146301 no 945 0.258642767155684 1237 703109
SGTC_1609 st001574 46.4 µM 0.646985592350261 0.276711958563924 no 946 0.258820634093988 1256 3960012
SGTC_824 1304-0008 100 µM 0.645979694612913 0.277027096833118 no 947 0.259146252848021 1276 768245
SGTC_2614 arthonioic acid 13.39 µM 0.64483618909861 0.277385559553577 no 948 0.259516673614073 1226 6710684
SGTC_2066 5222451 176 µM 0.643872681852761 0.277687772887041 no 949 0.259828998870419 1278 2281147
SGTC_53 0973-0023 39.979 µM 0.64316320986917 0.277910408375836 no 950 0.260059101353769 1261 674768
SGTC_893 0958-0369 48.9 µM 0.642965542991853 0.277972452642623 no 951 0.260123229203692 1294 6819948
SGTC_2138 5575593 77.673 µM 0.64116837902686 0.278536861707013 no 952 0.260706645810649 1275 762213
SGTC_3149 9097855 49.47 µM 0.63923514120661 0.279144628052232 no 953 0.261334987262215 1290 25236625 YMR079W SEC14
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.638217585706087 0.279464783307712 no 954 0.261666025608796 1259 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1359 1582-0056 520 nM 0.638200588778693 0.279470132594375 no 955 0.261671556995993 1326 3661189
SGTC_2387 9077560 195.08 µM 0.635882360285167 0.280200192847678 no 956 0.262426550395031 1256 5303272
SGTC_1670 st016595 4.04 µM 0.635706891564257 0.280255489333238 no 957 0.262483741870753 1276 597879
SGTC_2246 7293507 91.5585 µM 0.634576759140043 0.280611761186416 no 958 0.262852244910401 1311 887656
SGTC_1165 k072-0275 30.3 µM 0.634230984088445 0.280720809802073 no 959 0.262965044844112 1305 6153523 YGL055W OLE1
SGTC_3351 9150312 21.596 µM 0.632690946867419 0.281206746970068 no 960 0.26346774147812 1286 4904905
SGTC_2251 lansoprazole 556 µM 0.632535005637872 0.281255974678958 no 961 0.263518670914788 1214 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_642 0335-0876 158 µM 0.632237362983269 0.281349946406885 no 962 0.26361589310141 1311 6812350
SGTC_1805 st050013 60.3 µM 0.629899230184883 0.282088668236299 no 963 0.264380258291652 1267 4037144
SGTC_2174 5790901 200 µM 0.629606759339531 0.282181138671487 no 964 0.264475950036608 1298 786020
SGTC_935 2996-0153 430 µM 0.629535406556327 0.282203700477239 no 965 0.264499298191079 1296 23738523
SGTC_3171 9103192 49.47 µM 0.629088907389987 0.282344903574868 no 966 0.26464542606681 1333 13018434
SGTC_807 1315-0151 48 µM 0.628745132464748 0.282453643806562 no 967 0.264757962870379 1326 4011080
SGTC_991 3996-0057 64.7 µM 0.628556847214084 0.282513209279257 no 968 0.264819609498613 1303 715343
SGTC_3134 9127454 49.47 µM 0.627865668770638 0.282731920608701 no 969 0.265045971341191 1379 24262820
SGTC_595 3909-8003 73.7 µM 0.62621125604427 0.283255760746353 no 970 0.265588192607005 1337 699517
SGTC_2463 5473429 200 µM 0.626039951284027 0.2833100279137 no 971 0.265644368573564 1300 5399405
SGTC_338 4055-0136 114 µM 0.625288562846091 0.283548117083564 no 972 0.265890842525652 1262 2900563
SGTC_604 1000-0114 314 µM 0.624347321287655 0.283846499388086 no 973 0.266199756403178 1357 1572745
SGTC_2094 5332512 191.667 µM 0.623806967045696 0.284017864581761 no 974 0.266377181804537 1367 755774
SGTC_1493 4348-0038 111 µM 0.623054825695427 0.284256477227155 no 975 0.266624247106766 1353 800424
SGTC_1933 st074711 15.9 µM 0.622256814386122 0.28450974659067 no 976 0.266886506505336 1277 17250958
SGTC_623 k072-0108 16.9 µM 0.621977154355077 0.284598529374915 no 977 0.266978445144076 1301 5382803
SGTC_2096 5468907 200 µM 0.621815937868215 0.28464971627298 no 978 0.267031452564394 1312 759785
SGTC_1783 st039459 87.517 µM 0.620694785864524 0.285005808160245 no 979 0.26740023037843 1377 729761
SGTC_542 3381-0244 89.3 µM 0.619333006314876 0.285438611850401 no 980 0.267848502480776 1333 1112843
SGTC_72 0744-0168 198.391 µM 0.618621762936831 0.285664785085351 no 981 0.268082780757963 1296 677577
SGTC_400 oxethazaine 37.5 µM 0.618369150531722 0.285745135579018 no 982 0.268166014221135 1291 4621 A local anesthetic.
SGTC_1296 1068-0102 11.9 µM 0.616421206378619 0.286365094897837 no 983 0.268808280370541 1304 767053
SGTC_2787 5284540 71.43 µM 0.616303000452007 0.286402736055832 no 984 0.26884727947134 1339 736958
SGTC_1707 st032323 6.317 µM 0.616087899342999 0.286471238263197 no 985 0.268918254012775 1262 3132057 YMR211W DML1
SGTC_619 1652-1634 108 µM 0.615773255801419 0.286571455267959 no 986 0.269022090415521 1287 5400454
SGTC_1460 k062-0059 9.15 µM 0.615768035672403 0.286573118069664 no 987 0.269023813294713 1281 1373085
SGTC_620 0109-0052 432 µM 0.615666284785382 0.286605530356608 no 988 0.269057396805555 1318 493037
SGTC_237 nikkomycin 200 µM 0.614736475484349 0.286901797433143 no 989 0.26936438355579 1374 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3114 9122766 49.47 µM 0.613570146873559 0.287273632191483 no 990 0.269749707903546 1254 17176985
SGTC_1833 st055984 71 µM 0.610812787908559 0.288153605675967 no 991 0.270661763250981 1323 676288
SGTC_605 1315-0399 119 µM 0.610445637712875 0.288270872526887 no 992 0.270783322095478 1372 24020461
SGTC_1862 st057513 3.81 µM 0.610435301264521 0.288274174288261 no 993 0.270786744758835 1304 5393163
SGTC_114 0364-0001 490.298 µM 0.610261827119989 0.288329589622177 no 994 0.270844189723117 1301 4003655
SGTC_126 0417-1624 672.48 µM 0.609793391227896 0.288479253906637 no 995 0.270999339953357 1389 41912 YDL195W SEC31
SGTC_18 0111-0177 500 nM 0.609070662608831 0.288710235976698 no 996 0.271238801190127 1373 721752
SGTC_452 diindolylmethane 8 µM 0.608991976481986 0.288735389101734 no 997 0.271264878582684 1328 3071 Inhibits expression of several cancer promoting factors.
SGTC_3078 9116413 49.47 µM 0.60889351273602 0.288766865873772 no 998 0.271297512242083 1264 17177322
SGTC_1361 1608-0041 5.61 µM 0.608578300522761 0.288867643398544 no 999 0.271401995606553 1309 X1361
SGTC_813 k007-0158 173 µM 0.607956513043169 0.289066485618911 no 1000 0.271608158210968 1357 6523916
SGTC_2286 7945697 125 µM 0.607756909956827 0.289130330594554 no 1001 0.271674356022323 1282 1245733
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.60343822261561 0.290513325464322 no 1002 0.273108600577798 1359 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2434 5670830 169.91 µM 0.602024501947006 0.290966719974254 no 1003 0.273578913914411 1334 1549830
SGTC_3263 9137018 49.47 µM 0.601764833656627 0.291050034148884 no 1004 0.273665343313026 1269 43844957
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.601158815955479 0.291244517342706 no 1005 0.273867106060395 1373 279621
SGTC_263 alizarin 107.927 µM 0.599452584924562 0.291792406573025 no 1006 0.274435559871923 1348 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.599397313104857 0.291810162979265 no 1007 0.274453984154893 1379 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2331 7980721 200 µM 0.598343526760127 0.292148794464856 no 1008 0.274805369526767 1343 2981221
SGTC_2212 7123476 200 µM 0.597064877744357 0.292559930366242 no 1009 0.27523203301101 1320 1085715
SGTC_2022 5136654 200 µM 0.596060779420831 0.292882975771041 no 1010 0.275567312025004 1350 1713771
SGTC_431 k089-0097 107 µM 0.595029593476366 0.293214908213849 no 1011 0.275911844800384 1297 5499420
SGTC_1053 3366-3204 134 µM 0.594849756260972 0.293272814568088 no 1012 0.275971952439508 1292 3632071 YPR165W RHO1
SGTC_116 0155-0182 31.788 µM 0.588426791587463 0.295344431551647 no 1013 0.278122929582972 1336 771486
SGTC_1417 3966-0327 90.4 µM 0.587939783665596 0.295501781849515 no 1014 0.278286355872487 1400 651118
SGTC_401 neomycin 50 µM 0.583752775020313 0.296856175107593 no 1015 0.279693327492493 1351 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1475 4092-1048 11.7 µM 0.582877983823828 0.297139506718658 no 1016 0.279987721271374 1349 2881759
SGTC_1578 josamycin 24.2 µM 0.581452290245864 0.297601532003056 no 1017 0.280467832106178 1304 5282165 A P450 substrate.
SGTC_2311 7694451 200 µM 0.580216490607854 0.298002283352172 no 1018 0.280884317190822 1405 2163142
SGTC_417 st075190 100 µM 0.580109223855305 0.298037079954587 no 1019 0.280920481971744 1438 222757
SGTC_3027 9089541 49.47 µM 0.57941794104157 0.29826137178365 no 1020 0.281153600625996 1350 9943819
SGTC_2627 acetyl isogambogic acid 100 µM 0.579403758509516 0.298265974215727 no 1021 0.281158384324872 1303 6857789 A caspase activator and apoptosis inducer.
SGTC_919 tnp00227 403.569 nM 0.579314213197037 0.298295033681667 no 1022 0.281188588429536 1398 1269246 A methoxyflavone. YNL221C POP1
SGTC_1365 1672-3266 55.4 µM 0.576903562824338 0.299077827840162 no 1023 0.282002301830432 1374 6415873
SGTC_1836 st055642 81 µM 0.5758063514684 0.299434426419609 no 1024 0.282373039982527 1308 8571
SGTC_1398 3558-0053 112 µM 0.573622713131784 0.300144691578817 no 1025 0.283111569199136 1333 4532369
SGTC_1819 st053448 58.6 µM 0.572751316607786 0.300428340510062 no 1026 0.283406543103674 1387 2857616
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.571424499627678 0.300860466099103 no 1027 0.283855962821609 1444 94937 An inhibitor of serotonin biosynthesis.
SGTC_3002 9075603 71.4286 µM 0.57055283540606 0.301144507346601 no 1028 0.284151398664353 1352 20105405
SGTC_1626 st003712 1.76 µM 0.56883861206054 0.301703457777394 no 1029 0.284732834238065 1382 24207035
SGTC_66 0109-0187 42.4 µM 0.568389878242066 0.301849851747838 no 1030 0.284885130887709 1364 759417
SGTC_1204 4049-0315 18.3 µM 0.567812668651793 0.30203820630725 no 1031 0.285081088303818 1502 588402
SGTC_1189 1431-2119 7.28 µM 0.566660878047638 0.302414215324466 no 1032 0.285472302688558 1396 3107275
SGTC_3205 9113483 49.47 µM 0.566538461790542 0.302454191191281 no 1033 0.285513897317796 1465 17018033
SGTC_671 0560-0003 407 µM 0.565014160343387 0.302952160569176 no 1034 0.286032066347161 1388 3238678
SGTC_3200 9114385 49.47 µM 0.563368953675603 0.303490039464229 no 1035 0.286591836704046 1346 17018030 YLR208W SEC13
SGTC_1351 1496-0003 46.5 µM 0.562648866595306 0.303725596688712 no 1036 0.286837004800964 1390 3891978
SGTC_49 0717-0965 32.132 µM 0.561784003296954 0.304008621374295 no 1037 0.287131596180931 1466 5889349 YGL099W LSG1
SGTC_979 1426-2828 121 µM 0.560648783088072 0.304380298120502 no 1038 0.287518494314546 1470 747872
SGTC_2092 5303694 80.6725 µM 0.558016341048928 0.305242950120668 no 1039 0.288416612830472 1370 1963699
SGTC_1261 0712-0010 12.7 µM 0.556489617133367 0.305743754489261 no 1040 0.288938095188975 1461 2840123
SGTC_565 1418-0001 44.5 µM 0.556439664278981 0.305760146445659 no 1041 0.288955165054636 1443 2862145
SGTC_492 tmb-8 126 µM 0.553478432647008 0.306732564744437 no 1042 0.28996792245968 1331 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_625 k213-0058 121 µM 0.552170923239599 0.307162362510438 no 1043 0.290415626883285 1468 3655420
SGTC_1476 4112-3294 3.34 µM 0.551631740003213 0.307339677272551 no 1044 0.290600342860632 1472 704369
SGTC_2649 anisomycin 9.56 µM 0.550708267971415 0.307643473130655 no 1045 0.290916837963782 1379 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3346 9158254 43.5805 µM 0.550403032661955 0.307743915833931 no 1046 0.291021484535371 1400 17639500
SGTC_738 1315-0003 72.4 µM 0.549852635859284 0.307925069379429 no 1047 0.291210226462772 1462 6251474
SGTC_992 3909-8734 162 µM 0.547944395006323 0.308553496040207 no 1048 0.291865042048778 1406 4288319
SGTC_2659 sanguinarine 24.21 µM 0.547543983803852 0.308685431757732 no 1049 0.292002530735984 1379 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1271 0832-2808 169 µM 0.546949924591835 0.308881220106471 no 1050 0.292206567631932 1451 3663794
SGTC_2189 6047310 154.431 µM 0.546180038408645 0.30913503782181 no 1051 0.292471093090901 1366 711535
SGTC_228 caffeine 993.056 µM 0.543791875108805 0.309922951971703 no 1052 0.293292350267917 1433 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_810 3825-7150 143 µM 0.542457016511179 0.310363735820082 no 1053 0.293751855339301 1502 22330411 YGL099W LSG1
SGTC_171 k064-0041 9.68 µM 0.541856182604533 0.310562226244983 no 1054 0.293958792070805 1367 53325
SGTC_1559 coumarin 343 70.1 µM 0.540140720589124 0.311129246692621 no 1055 0.294549995067118 1485 108770 A hepatotoxic, DNA x-linker.
SGTC_2110 5483698 200 µM 0.53896170569432 0.311519212710944 no 1056 0.294956639105348 1431 2848765 YHR062C RPP1
SGTC_1171 0368-0077 21.4 µM 0.538735046983504 0.311594205649788 no 1057 0.295034843675562 1408 3239779
SGTC_2028 5153890 36.43 µM 0.537055381768674 0.312150187807248 no 1058 0.29561467980495 1396 2830968 YPR165W RHO1
SGTC_2670 beta-carotene 100 µM 0.536852527099159 0.312217363268227 no 1059 0.295684742571124 1376 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1295 1013-0063 9.78 µM 0.534612047410345 0.312959714502147 no 1060 0.296459075595094 1485 6826038
SGTC_723 4182-0001 115 µM 0.533568528175353 0.313305729102677 no 1061 0.296820043618327 1384 744821 YLR208W SEC13
SGTC_1457 k015-0032 57.3 µM 0.529474478163908 0.314664837435444 no 1062 0.298238172217464 1433 4302660
SGTC_2206 7254556 146.969 µM 0.528485775054865 0.31499343648102 no 1063 0.298581108801459 1459 4398905
SGTC_1879 gemcitabine 100 µM 0.528297657216744 0.315055974718374 no 1064 0.298646378711076 1445 60750 A nucleoside analog which inhibits DNA replication.
SGTC_247 mechlorethamine 29.705 µM 0.526866964514581 0.315531770198737 no 1065 0.299142988145512 1419 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2707 st078556 66.6 µM 0.526111618013946 0.315783093980702 no 1066 0.299405328453899 1476 17250899
SGTC_1696 st025591 34.7925 µM 0.525930373790832 0.315843411411325 no 1067 0.299468292120694 1454 2787147
SGTC_1218 1348-1416 30.7 µM 0.52306437000603 0.316797858277364 no 1068 0.300464729603695 1439 6787668
SGTC_2265 7929201 200 µM 0.522906713301485 0.31685039715734 no 1069 0.30051958630974 1393 1265108
SGTC_2675 theaflavin digallate 100 µM 0.522401174708251 0.317018892106402 no 1070 0.30069551913872 1457 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_471 1-acyl-paf 4 µM 0.521288293235115 0.317389946847511 no 1071 0.30108297747298 1380 16759367
SGTC_3325 9138760 55.175 µM 0.521234420274677 0.317407913725104 no 1072 0.301101739471261 1415 43844959
SGTC_571 k831-0106 44.2 µM 0.520065827511714 0.317797750552656 no 1073 0.301508847544641 1526 4783639
SGTC_1004 4084-0029 199 µM 0.519302019864833 0.318052662268389 no 1074 0.301775072525805 1501 716894 YLR208W SEC13
SGTC_2972 9093619 59.92 µM 0.518660818037129 0.31826672232883 no 1075 0.301998644829644 1396 25236256
SGTC_3181 9108277 49.47 µM 0.517534918507738 0.318642741653264 no 1076 0.302391399946145 1399 17097298
SGTC_1092 toremifene 6.32 µM 0.513880145457735 0.319864620816296 no 1077 0.303667894801269 1441 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2869 9037858 32.47 µM 0.513423958536578 0.320017272810146 no 1078 0.303827394954911 1396 27187042
SGTC_103 0844-0104 51.839 µM 0.511961414489285 0.320506883426293 no 1079 0.304339007301221 1498 5375804
SGTC_511 blebbistatin 171 µM 0.510836686914656 0.320883617076822 no 1080 0.304732708822804 1533 3476986 A myosin inhibitor.
SGTC_821 1114-0266 29.2 µM 0.510600245542808 0.320962837889919 no 1081 0.304815501951173 1445 3123235
SGTC_2156 5649887 115 µM 0.510022752507289 0.321156363956718 no 1082 0.30501776092524 1559 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1279 0874-0590 65.2 µM 0.50696793801328 0.32218088255964 no 1083 0.306088657576212 1489 3523074
SGTC_2946 9065502 71.43 µM 0.506022696346031 0.322498170512106 no 1084 0.30642035836146 1373 16489101
SGTC_446 go6976 132 µM 0.505939590718679 0.322526072650339 no 1085 0.306449529080255 1515 3501 A protein kinase C inhibitor.
SGTC_2313 7726885 200 µM 0.504784167573465 0.3229141014595 no 1086 0.30685521855494 1477 726423
SGTC_2890 9046729 58.44 µM 0.504212607521733 0.32310612130337 no 1087 0.307055990909178 1407 903329
SGTC_581 0958-0271 211 µM 0.500863331135001 0.324232281842972 no 1088 0.308233655398294 1445 4591145
SGTC_1729 st035615 45.989 µM 0.500439483966694 0.324374911163326 no 1089 0.308382828663396 1459 17385451
SGTC_502 l-744,832 89.3 µM 0.500262574290266 0.324434450875388 no 1090 0.30844510149179 1543 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.500159665890157 0.324469087204701 no 1091 0.308481328146192 1503 368090
SGTC_634 1611-4317 11.2 µM 0.498995357434742 0.324861069300715 no 1092 0.308891327329833 1523 2843522
SGTC_2213 7173844 200 µM 0.498803561232434 0.324925659022131 no 1093 0.308958889248593 1456 892728
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.496843740909006 0.325585953888814 no 1094 0.309649623544664 1586 165506
SGTC_702 1488-0190 94 µM 0.496766004826743 0.32561215572623 no 1095 0.30967703534129 1567 949357
SGTC_1030 k029-0042 36.7 µM 0.494945924241812 0.326225880780562 no 1096 0.310319146125866 1530 6080581
SGTC_2915 7971052 15.16 µM 0.494466295376839 0.326387688483558 no 1097 0.310488452002325 1396 5741558
SGTC_245 methotrexate 289.6 µM 0.493486720876166 0.326718259455933 no 1098 0.310834360172486 1512 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_683 panaxydol 45 µM 0.493140145233262 0.326835248805756 no 1099 0.310956783323178 1521 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_45 0kpi-0036 14.9 µM 0.492680167220822 0.326990544313123 no 1100 0.31111929663842 1529 2795021
SGTC_1026 k007-1105 30.6 µM 0.492544780679131 0.327036258558459 no 1101 0.311167136628407 1474 7066794
SGTC_1945 st075991 56.6 µM 0.489486722467871 0.328069524318042 no 1102 0.312248576188935 1442 1084980
SGTC_1915 st067105 30.6 µM 0.488373944992892 0.328445840133936 no 1103 0.312642496798554 1446 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_19 0279-0214 38.434 µM 0.487551061319348 0.32872423251733 no 1104 0.312933933428544 1523 3566274 YBR002C RER2
SGTC_386 1509-0011 3.07 µM 0.486600533538231 0.329045926920664 no 1105 0.313270722694526 1495 3107280
SGTC_1762 st045503 25.4615 µM 0.484296596568572 0.329826191134057 no 1106 0.314087695499296 1502 4645554
SGTC_563 tetrahydrosecaminediol 614 µM 0.484140056421233 0.329879232822628 no 1107 0.314143237543199 1604 334274 A psychoactive constituent of the cannabis plant.
SGTC_291 SEC14.278 35.5 µM 0.484118499447466 0.329886537403983 no 1108 0.314150886507558 1587 1068044
SGTC_489 paxilline 115 µM 0.483972294096297 0.32993608080446 no 1109 0.314202766003388 1450 105008 A toxic potassium channel blocker.
SGTC_1118 chelidonine 707.474 nM 0.482482819528214 0.330440976630249 no 1110 0.31473150010286 1623 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_283 0987-0079 11.7 µM 0.482245965012821 0.330521293057557 no 1111 0.31481561383651 1552 411556
SGTC_1761 st044296 37 µM 0.481361140715807 0.330821402493959 no 1112 0.315129924917986 1479 1826700
SGTC_535 2293-4129 48.2 µM 0.481353579935306 0.330823967383407 no 1113 0.315132611268103 1614 396118 YIL048W NEO1
SGTC_1947 st076332 61.6 µM 0.480020046207476 0.331276474259039 no 1114 0.315606569471681 1523 24208416
SGTC_138 0850-0259 40.9225 µM 0.479000491595293 0.331622605167259 no 1115 0.31596913946499 1490 6813004
SGTC_2630 antimycin a 100 µM 0.478974182762759 0.331631538717192 no 1116 0.315978497653652 1445 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1867 st057372 64 µM 0.47073233770161 0.334434869764369 no 1117 0.318915944249977 1506 688837
SGTC_722 3534-0461 190 µM 0.470130305987798 0.334640005831877 no 1118 0.319130961609195 1499 658262
SGTC_2399 5884133 200 µM 0.469617169414098 0.334814890777003 no 1119 0.319314277863857 1500 722445
SGTC_579 4491-1009 110 µM 0.469205569394331 0.334955196382253 no 1120 0.319461352472001 1658 1271041
SGTC_2897 9048598 12.99 µM 0.465888299347055 0.3360868220876 no 1121 0.320647728386559 1506 6467404
SGTC_1616 st002734 56.1 µM 0.465590213703033 0.336188581498167 no 1122 0.320754424611507 1553 4026101
SGTC_2803 7707263 71.43 µM 0.465408654802782 0.336250567308967 no 1123 0.320819418726317 1512 2199229
SGTC_3119 9125183 49.47 µM 0.464948274511616 0.336407765157246 no 1124 0.320984249416298 1478 22695334
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.462465075676504 0.337256151368516 no 1125 0.321873920820447 1553 688662
SGTC_2393 9031399 185.94 µM 0.461604903337309 0.337550223065126 no 1126 0.322182338831126 1609 1526623 YDL150W RPC53
SGTC_74 000s-0487 160.283 µM 0.460335799622613 0.337984279480165 no 1127 0.322637604335707 1430 677548
SGTC_786 4544-0069 423 µM 0.458897998158111 0.338476293940129 no 1128 0.323153708191994 1601 748821 YLR208W SEC13
SGTC_3355 9151058 44.0485 µM 0.457948089516588 0.338801503272243 no 1129 0.32349486813442 1525 17015728
SGTC_2323 6148992 148.28 µM 0.457272711188242 0.339032797936034 no 1130 0.32373752074461 1492 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2943 9068529 45.32 µM 0.457227737072038 0.339048202234356 no 1131 0.323753681886496 1522 3270634
SGTC_842 0271-0008 11.1 µM 0.45713492295279 0.339079993290195 no 1132 0.323787035057737 1596 1221709
SGTC_2866 9034245 58.44 µM 0.453856705360463 0.340203594745435 no 1133 0.324965983335817 1648 6462273
SGTC_2686 alizarin 95.37 µM 0.453437329834706 0.340347437415566 no 1134 0.325116930582202 1493 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1435 4092-0789 56.7 µM 0.45336323021049 0.340372855448359 no 1135 0.32514360449451 1633 2248285
SGTC_1080 nisoldipine 24.4 µM 0.452348728689187 0.340720927847487 no 1136 0.325508888380995 1540 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1825 st052143 62.6 µM 0.452068729238007 0.340817018712547 no 1137 0.325609735201811 1604 674173
SGTC_100 0086-0128 49.5915 µM 0.451939565424652 0.340861348933292 no 1138 0.325656260167329 1448 93297
SGTC_2993 9054257 71.4286 µM 0.450990467462159 0.341187155536928 no 1139 0.325998209688321 1520 6470217 YGL055W OLE1
SGTC_2886 9058944 51.95 µM 0.449312934504326 0.341763309043714 no 1140 0.32660296420129 1510 4949929
SGTC_1306 1185-0270 9.02 µM 0.444491270124235 0.34342137294612 no 1141 0.328343719541469 1646 1548076
SGTC_3152 9099253 49.47 µM 0.444157041490435 0.34353641899926 no 1142 0.328464524191267 1624 25236131
SGTC_79 0052-0007 94.094 µM 0.442576805438712 0.34408055392754 no 1143 0.329035932358734 1651 2801472
SGTC_1216 1165-0504 9.65 µM 0.442098871267059 0.34424518837798 no 1144 0.329208830576426 1644 6304004
SGTC_1283 0922-0125 16.4 µM 0.441416452085309 0.344480313143838 no 1145 0.329455766933654 1666 3360884
SGTC_871 0574-0004 149 µM 0.440993898349637 0.344625932460256 no 1146 0.329608707146792 1572 9551173
SGTC_1840 st055363 71 µM 0.440152723507754 0.34491588436842 no 1147 0.329913249009498 1502 676033
SGTC_2517 totarol 10 µM 0.437375583970042 0.345873806930616 no 1148 0.330919494099976 1510 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2986 9022445 71.43 µM 0.436246101800014 0.346263683576633 no 1149 0.331329091250763 1682 6459286
SGTC_1768 st044301 37.178 µM 0.435759895982203 0.346431563159752 no 1150 0.331505471854077 1535 3931349
SGTC_256 clotrimazole 625 nM 0.435408596786028 0.346552880285573 no 1151 0.331632935719489 1580 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.435319446713656 0.346583669739407 no 1152 0.331665285644631 1531 2333 A French combination drug.
SGTC_3137 9097352 49.47 µM 0.434892663015003 0.346731080593796 no 1153 0.331820170217062 1650 44120435
SGTC_1231 0242-0792 125 µM 0.433668376995769 0.347154077016273 no 1154 0.332264636742031 1539 3707635
SGTC_2252 omeprazole 400 µM 0.43322438532801 0.347307525265367 no 1155 0.332425882455696 1647 4594 A proton pump inhibitor.
SGTC_2388 9080168 200 µM 0.432429215328305 0.347582407033768 no 1156 0.33271474410569 1506 15943073
SGTC_3354 9151612 71.43 µM 0.431408415443676 0.347935404134114 no 1157 0.333085715998644 1669 27261949
SGTC_2893 9048488 25.97 µM 0.430467855424969 0.348260770642254 no 1158 0.333427672336198 1507 6467338
SGTC_2825 7998094 58.44 µM 0.42919526537149 0.348701173587173 no 1159 0.33389056413991 1591 2987815
SGTC_190 3970-0790 3.722 µM 0.428253720902399 0.349027143499324 no 1160 0.334233204255375 1641 2832352
SGTC_2726 cimetidine 79.27 µM 0.426355550668895 0.349684643164972 no 1161 0.334924392620399 1607 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2200 6600604 21.907 µM 0.425609231923264 0.34994328122453 no 1162 0.335196306046942 1555 2904777
SGTC_1802 st050112 57.9 µM 0.425233324595156 0.350073578941219 no 1163 0.335333296669525 1589 4662563
SGTC_1081 sertraline 6 µM 0.421708312284605 0.351296282520694 no 1164 0.336618968238348 1686 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1486 3970-0793 4.53 µM 0.420751971889594 0.351628269806294 no 1165 0.336968102981266 1664 2844330
SGTC_69 0096-0274 206.684 µM 0.419915505104524 0.351918736566211 no 1166 0.337273590227192 1675 6741392
SGTC_1243 0416-0003 5.65 µM 0.418604808836581 0.352374055388919 no 1167 0.337752487276258 1579 2141977
SGTC_779 1360-0071 233 µM 0.418391363094127 0.352448223718323 no 1168 0.337830500145855 1757 7566
SGTC_2702 st077768 96.8 µM 0.416442455655165 0.353125691107696 no 1169 0.338543133533122 1565 6484119
SGTC_854 0422-0053 192 µM 0.415941114984353 0.353300039518977 no 1170 0.338726546362198 1571 3596728
SGTC_1458 k015-0034 6.33 µM 0.414741098217353 0.353717487570603 no 1171 0.339165721424125 1528 3598957
SGTC_514 4466-0038 2.65 nM 0.41380770407462 0.354042307698089 no 1172 0.339507470699513 1647 5722064
SGTC_478 N-arachidonylglycine 10 µM 0.41254444838995 0.354482088445782 no 1173 0.339970204396846 1620 5283389
SGTC_2031 5180455 200 µM 0.412163574631964 0.354614721201404 no 1174 0.340109766756324 1583 29949
SGTC_1675 st018485 24.5 µM 0.41209555408442 0.354638410046513 no 1175 0.340134693615578 1609 3323024
SGTC_2706 st078239 82.5 µM 0.411199176921917 0.354950634966276 no 1176 0.340463245880472 1607 15434492
SGTC_505 gw-5074 63.9 µM 0.410740696427839 0.355110369968956 no 1177 0.340631341177531 1686 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_295 k015-0027 31 µM 0.409337145312192 0.35559952660003 no 1178 0.34114612973867 1598 3887424
SGTC_1677 st019204 53.9 µM 0.409203829745179 0.35564600127095 no 1179 0.341195042058418 1540 3945625
SGTC_2207 7258803 200 µM 0.408251027028336 0.355978216914925 no 1180 0.341544694714107 1668 3666799
SGTC_2068 5226020 147 µM 0.405380269165598 0.35697983022538 no 1181 0.342599006009364 1580 1810509
SGTC_3068 9116768 49.47 µM 0.405351805734292 0.356989766125744 no 1182 0.342609465615524 1600 41904888
SGTC_1774 st048371 48.465 µM 0.404029086020225 0.357451602704541 no 1183 0.3430956653485 1590 4242727
SGTC_1754 st042065 16.137 µM 0.400921651351941 0.358537405260376 no 1184 0.344238904322104 1589 1126236 YIL048W NEO1
SGTC_3167 9103034 49.47 µM 0.400132135029194 0.358813461441365 no 1185 0.344529598290029 1635 5127859
SGTC_2914 7968218 45.32 µM 0.399274116041474 0.359113553376985 no 1186 0.344845618566063 1716 2977111
SGTC_2327 6189656 200 µM 0.398999742008093 0.359209533986646 no 1187 0.344946697181117 1749 5349088
SGTC_1009 4106-0057 9.87 µM 0.398290888722201 0.359457543801932 no 1188 0.345207887930133 1678 2928005
SGTC_2961 9083290 32.55 µM 0.395635192169156 0.360387230525082 no 1189 0.346187085711468 1644 17741490
SGTC_1278 0874-0585 172 µM 0.395496449153362 0.360435823412172 no 1190 0.346238270824139 1668 766306
SGTC_196 k015-0023 18.111 µM 0.394886098352135 0.360649617384888 no 1191 0.346463474959267 1631 5211998
SGTC_2997 9067075 71.4286 µM 0.394131282449995 0.360914074907951 no 1192 0.346742058163897 1693 27209819
SGTC_1424 4048-1941 275 µM 0.393998634834456 0.360960556240445 no 1193 0.346791023566295 1748 X1424
SGTC_378 3970-0959 8.33 µM 0.393227495603164 0.361230813423826 no 1194 0.34707573175769 1672 6615653
SGTC_185 k048-0037 25.491 µM 0.392835318330233 0.36136828434957 no 1195 0.347220558563002 1749 6827589
SGTC_3179 9107801 49.47 µM 0.392402716318235 0.361519946228844 no 1196 0.34738033966696 1610 4818259
SGTC_711 k292-0785 179 µM 0.39160199783605 0.36180072000449 no 1197 0.347676155758112 1594 4146315
SGTC_1865 st057639 52.2 µM 0.391510253277644 0.3618328951988 no 1198 0.347710055640433 1634 688818
SGTC_262 fenpropimorph 62.5 µM 0.39143131403032 0.36186058029953 no 1199 0.347739224897508 1596 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2725 haloperidol 53.21 µM 0.390247825805774 0.362275732805886 no 1200 0.348176649831602 1617 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_165 k038-0023 64.381 µM 0.389464597420612 0.362550568426126 no 1201 0.348466247278745 1595 46368543
SGTC_444 curcumin 90.4 µM 0.388256174081669 0.362974744307686 no 1202 0.348913233146608 1675 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_3088 9117578 49.47 µM 0.387935146475934 0.363087458413182 no 1203 0.349032013908988 1660 678341
SGTC_387 norethindrone acetate 66.7 µM 0.386862466524567 0.3634641666997 no 1204 0.349429014564543 1622 541197
SGTC_1001 4048-4355 44.4 µM 0.385648392640942 0.363890689626575 no 1205 0.349878544125361 1606 21824233
SGTC_1415 3966-0071 78.1 µM 0.384933820509392 0.364141808765726 no 1206 0.350143223920841 1668 2893185
SGTC_2006 4011487 200 µM 0.384448870159936 0.364312266108495 no 1207 0.350322892559191 1771 45595294
SGTC_741 4582-0002 126 µM 0.384025771727048 0.364461004773178 no 1208 0.350479673124558 1610 2912688
SGTC_937 3122-0005 46.7 µM 0.383587380328716 0.364615141152701 no 1209 0.350642147423826 1763 759535
SGTC_599 1935-0052 86.5 µM 0.382910754215134 0.36485308270907 no 1210 0.3508929686346 1630 9557311
SGTC_2847 9005661 71.43 µM 0.382470670068559 0.365007870138784 no 1211 0.351056140057133 1658 2991449
SGTC_2945 9067681 61.76 µM 0.381852517103163 0.365225325501064 no 1212 0.351285381012003 1678 16456930
SGTC_725 1497-0963 19 µM 0.380790547629467 0.365599008876159 no 1213 0.351679336854579 1793 3549977
SGTC_2680 butyl paraben 22.24 µM 0.38052724513018 0.365691678906388 no 1214 0.351777038111615 1668 7184 An antifungal and steroid mimetic.
SGTC_2461 5755302 26.15 µM 0.379673619145256 0.365992168768161 no 1215 0.352093852606407 1766 2788904
SGTC_2310 7668677 200 µM 0.37799937572176 0.366581767579616 no 1216 0.35271552886684 1709 2197143
SGTC_2248 tofa 1.1 µM 0.377246168811792 0.366847118499534 no 1217 0.352995336386878 1681 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2679 rapamycin 1 nM 0.37696403114228 0.366946530539114 no 1218 0.353100167695882 1688 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_697 0508-1955 564 µM 0.376927806751487 0.366959294956509 no 1219 0.353113628068734 1781 6243113
SGTC_1778 st046819 58.9 µM 0.375226625882863 0.367558906833922 no 1220 0.353745964919866 1651 671715
SGTC_1109 tnp00067 928.257 nM 0.375207511646329 0.36756564582903 no 1221 0.353753072067368 1645 676295
SGTC_2302 7771753 200 µM 0.372593391962625 0.368487674140011 no 1222 0.354725545860049 1608 2203047
SGTC_1445 4239-0156 97.7 µM 0.371844731431817 0.368751874630733 no 1223 0.355004228483123 1795 4008346
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.370814272091171 0.369115622687176 no 1224 0.355387935226927 1851 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2072 5231554 129 µM 0.369914725885795 0.369433254783465 no 1225 0.355723014428525 1830 789545
SGTC_1478 0453-0656 35.7 µM 0.368427922768087 0.369958444159581 no 1226 0.356277090056065 1688 5258496
SGTC_1340 1486-1359 257 µM 0.365642154193855 0.370943124748357 no 1227 0.357316057764091 1692 4309068
SGTC_340 k038-0059 454 µM 0.363212190554857 0.371802730486079 no 1228 0.358223190916194 1717 23733424
SGTC_2298 7976326 193.81 µM 0.362065679428204 0.372208533995505 no 1229 0.358651475002215 1719 2235818
SGTC_1373 2887-0003 58.5 µM 0.361488418782924 0.372412907094653 no 1230 0.358867180497056 1677 776948
SGTC_298 1391-0729 10 µM 0.357077591627852 0.373975696788184 no 1231 0.360516859717664 1691 3237558
SGTC_696 1560-0013 611 µM 0.356865486406294 0.37405089974701 no 1232 0.360596254258047 1759 1650269
SGTC_1575 cyproterone acetate 48 µM 0.356749759341099 0.374091933373734 no 1233 0.360639575372979 1619 9880 An androgen receptor antagonist and liver toxin.
SGTC_972 1319-0219 195 µM 0.356055600347867 0.374338092943015 no 1234 0.360899463444795 1656 23903702
SGTC_1711 st032263 62.8 µM 0.355950229887834 0.374375463427371 no 1235 0.360938918996305 1722 3958979
SGTC_2242 6630449 61.2675 µM 0.355522279433543 0.374527251638431 no 1236 0.361099178555626 1730 691249 YDR170C SEC7
SGTC_2220 6782180 200 µM 0.35552113697046 0.374527656880599 no 1237 0.361099606419646 1771 833803
SGTC_2789 5281112 71.43 µM 0.352547381757003 0.375582943667961 no 1238 0.362213895440315 1634 765948
SGTC_3278 9139605 49.47 µM 0.351026282390092 0.376123091837505 no 1239 0.362784315487787 1784 7958859
SGTC_208 k072-0098 12.366 µM 0.350689479831898 0.376242724569636 no 1240 0.362910659408019 1710 5948901
SGTC_249 wiskostatin 11.211 µM 0.349636956160458 0.376616659024439 no 1241 0.363305586173023 1786 2775510 A n-wasp and actin depolymerizer.
SGTC_870 0573-2213 57.6 µM 0.34869819789731 0.37695027328664 no 1242 0.363657948661122 1657 3916321
SGTC_1018 4259-0013 28.1 µM 0.34640728312559 0.377764799837267 no 1243 0.364518326208276 1717 6801262
SGTC_42 0133-0086 60.653 µM 0.345853685328691 0.377961711274698 no 1244 0.36472633840669 1615 162923 Model of phenazepam hydroxylation.
SGTC_453 enantio-paf c16 10 µM 0.343772726249761 0.378702179267105 no 1245 0.36550860640951 1707 13871343 A lipid and platelet activating factor
SGTC_2856 9022925 19.48 µM 0.343658927462622 0.37874268517889 no 1246 0.365551401485342 1726 4944862
SGTC_1845 st056753 3.01 µM 0.340723580276056 0.379787961343337 no 1247 0.366655842635794 1650 5375839
SGTC_374 0880-0231 82.3 µM 0.340708376213521 0.379793377799626 no 1248 0.366661566135425 1785 6833587
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.338574280740181 0.380553884096199 no 1249 0.367465230200958 1697 279621
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.336950767739566 0.381132748712981 no 1250 0.368077006815762 1722 88881 An O-methylated flavonoid and antioxidant.
SGTC_1818 st052136 56.3 µM 0.336599254496514 0.381258116075078 no 1251 0.368209509134415 1664 674169
SGTC_1831 st055328 12 µM 0.33582860075954 0.381533013683752 no 1252 0.368500060595147 1827 1103068
SGTC_287 k060-0039 29.6 µM 0.335596815930036 0.381615704660461 no 1253 0.368587462706158 1824 5861974
SGTC_1094 duloxetine 25.4 µM 0.335293891014797 0.381723783541154 no 1254 0.368701700780377 1738 60834 A selective serotonin reuptake inhibitor.
SGTC_1299 1079-1439 3.74 µM 0.334469470902652 0.382017970440596 no 1255 0.369012662188969 1675 323161
SGTC_1276 0871-0068 94.2 µM 0.332076374004366 0.382872310929354 no 1256 0.369915794813574 1804 3414906
SGTC_1483 3453-0561 55.9 µM 0.331619703238933 0.38303540823806 no 1257 0.3700882198558 1786 4546991
SGTC_1758 st042942 75.2445 µM 0.331023188125661 0.383248481374943 no 1258 0.370313485214932 1803 669317
SGTC_1687 st020778 55.3625 µM 0.328984358166526 0.383977010714882 no 1259 0.371083755474843 1763 4259299
SGTC_799 1310-0557 151 µM 0.328022052732321 0.384321011248274 no 1260 0.371447494320744 1762 5354492
SGTC_558 k064-0027 21.3 µM 0.327182923473188 0.384621053719559 no 1261 0.371764767924018 1805 5088526
SGTC_2617 dihydrotanshinone i 20.83 µM 0.326569057483517 0.384840593932368 no 1262 0.37199692498803 1690 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2929 9013348 24.6 µM 0.326094333580267 0.385010397333721 no 1263 0.372176492033287 1732 2995952
SGTC_2071 5230951 39.92 µM 0.325552500946419 0.385204231722984 no 1264 0.372381477312196 1812 1799272
SGTC_1954 st077032 68.9 µM 0.323942247247517 0.385780450573056 no 1265 0.372990879199895 1650 698907
SGTC_639 0833-0042 114 µM 0.322492093524502 0.386299594508376 no 1266 0.373539963270786 1696 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_995 3931-2021 34.6 µM 0.322254985695642 0.386384496688636 no 1267 0.37362976588864 1772 730143
SGTC_322 k048-0136 19.3 µM 0.32122219721321 0.386754374931527 no 1268 0.374021005916651 1779 6823282
SGTC_1244 0416-0015 52.5 µM 0.320966565266534 0.386845941710308 no 1269 0.374117864243722 1746 96201
SGTC_3005 9076496 71.4286 µM 0.320545944561585 0.38699662079167 no 1270 0.374277253707017 1818 21368410
SGTC_294 k038-0071 157 µM 0.319993258233772 0.387194635670493 no 1271 0.374486720614637 1750 24152826
SGTC_840 0245-0196 390 µM 0.319400028531634 0.387407208979665 no 1272 0.374711594595845 1813 3827528
SGTC_1896 st058441 89 µM 0.319218670541033 0.387472202130342 no 1273 0.374780349987789 1702 688759
SGTC_3004 9076122 71.4286 µM 0.318605246967451 0.387692057720254 no 1274 0.375012937073232 1836 44782551
SGTC_219 mitoxanthrone 164.414 µM 0.318248585095819 0.387819904560371 no 1275 0.375148190709958 1819 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1509 1326-1131 80 µM 0.317220361256592 0.388188543434132 no 1276 0.37553820055957 1869 768313
SGTC_2233 sulbentine 40.3845 µM 0.316623037771244 0.388402742178878 no 1277 0.375764826448097 1768 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_161 4065-0411 162.148 µM 0.31594610870024 0.38864552832109 no 1278 0.376021706687523 1782 1906281 YLR208W SEC13
SGTC_2878 9043973 25.97 µM 0.315689004613283 0.388737752207319 no 1279 0.376119286644188 1844 6465167
SGTC_1956 st077085 54 µM 0.315292740187361 0.388879905538328 no 1280 0.376269698305866 1720 24208685
SGTC_2757 clomiphene 4.22 µM 0.314767965023488 0.389068182874289 no 1281 0.376468918219162 1894 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1643 st009866 20.2 µM 0.314191514448095 0.389275030192045 no 1282 0.376687793550584 1845 3156273 YOR207C RET1
SGTC_1672 st016598 6.51 µM 0.312924934694485 0.389729626177469 no 1283 0.377168846557512 1716 4665860 YNL267W PIK1
SGTC_1209 2323-2347 50.3 µM 0.311557433712953 0.390220613830163 no 1284 0.377688444003774 1898 5412760
SGTC_327 1273-0057 3.96 µM 0.310628697429543 0.390554167300784 no 1285 0.378041454155045 1795 3108138
SGTC_1713 st033146 12.748 µM 0.30951805432303 0.390953157941924 no 1286 0.378463740308459 1877 674619
SGTC_2771 fluoxetine 41.05 µM 0.309336016524174 0.391018564689359 no 1287 0.378532968160788 1849 3386 A selective serotonin reuptake inhibitor.
SGTC_346 4513-0042 7.16 µM 0.306850150715093 0.391912051746938 no 1288 0.379478716825504 1736 2827372
SGTC_26 0302-0163 425.158 µM 0.306582450888433 0.392008304366694 no 1289 0.379580606471185 1809 3100915
SGTC_618 k072-0232 33.2 µM 0.304643518339895 0.392705652820194 no 1290 0.380318835818108 1783 5872756 YGL099W LSG1
SGTC_709 3807-1509 243 µM 0.304251179255135 0.392846801858626 no 1291 0.3804682681775 1790 1886677 YPL242C IQG1
SGTC_2370 9071495 200 µM 0.302215236955507 0.393579484220329 no 1292 0.381243994792552 1738 21791103
SGTC_485 niflumic acid 177 µM 0.301642765602552 0.393785569694012 no 1293 0.381462201669397 1827 4488 A COX2 inhibitor.
SGTC_2198 6589944 200 µM 0.301386816100017 0.393877719259096 no 1294 0.381559773228573 1837 5290268
SGTC_2183 6420625 130.508 µM 0.301050967245725 0.393998644022005 no 1295 0.381687814964475 1756 2897619
SGTC_1982 st072467 71.9 µM 0.300702681386897 0.39412405761168 no 1296 0.381820611959172 1753 3163533
SGTC_1267 0828-0272 9.49 µM 0.298895496532645 0.39477497935912 no 1297 0.382509891687516 1890 745334
SGTC_3310 9130229 44.1445 µM 0.297558285918951 0.395256812475591 no 1298 0.383020158041121 1871 7761258
SGTC_1929 genistein trimethyl ether 50.5 µM 0.296625898446242 0.395592871708469 no 1299 0.383376068097991 1958 136420
SGTC_1498 4478-3555 97.6 µM 0.29595091148844 0.395836204865522 no 1300 0.383633784924102 1907 3437919
SGTC_1024 4507-0395 26 µM 0.294921012272821 0.396207562287702 no 1301 0.38402711000594 1800 4201836
SGTC_946 3434-1334 87.4 µM 0.294044390964138 0.396523725533173 no 1302 0.384361991427207 1855 4047976
SGTC_3302 9125395 16.351 µM 0.293927489750607 0.396565892405725 no 1303 0.384406655831018 1796 17599668
SGTC_2496 diffractaic acid 79.83 µM 0.293076753365267 0.396872793827638 no 1304 0.384731742558878 1913 94870 An apoptosis inducer which activates caspases.
SGTC_945 3381-0768 11.3 µM 0.292052137422264 0.397242506737611 no 1305 0.385123380416833 1900 1126236 YIL048W NEO1
SGTC_1610 st001799 48.1 µM 0.292009219681976 0.397257994794228 no 1306 0.385139787379131 1726 621897
SGTC_1322 1348-1070 12 µM 0.291988469019924 0.397265483304113 no 1307 0.385147720194153 1894 6758089
SGTC_2026 5148700 152 µM 0.291982477064109 0.39726764569134 no 1308 0.385150010880714 1772 79838
SGTC_1395 3486-0190 4.35 µM 0.291892700173074 0.397300044906842 no 1309 0.385184332494413 1928 6748079
SGTC_1975 st070967 30.8 µM 0.290996470731701 0.397623520302313 no 1310 0.385527009358574 1925 261391
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.290422464859692 0.397830732797348 no 1311 0.385746529740233 1721 23665772 A membrane-active detergent.
SGTC_1103 duloxetine 36.1 µM 0.290105993634832 0.39794498924232 no 1312 0.385867575314597 1886 60835 A selective serotonin reuptake inhibitor.
SGTC_429 1112-0049 25.5 µM 0.289959178388997 0.397997997312385 no 1313 0.385923733754552 1736 2836170
SGTC_3241 9133421 49.47 µM 0.288037540476012 0.398691983509281 no 1314 0.386659001329816 1821 17018221
SGTC_3238 9133470 49.47 µM 0.287744638747616 0.39879779113418 no 1315 0.386771108801361 1901 3534688
SGTC_201 4262-0159 12.803 µM 0.286807069322951 0.399136528060882 no 1316 0.387130024857098 1925 1341029
SGTC_1932 st074806 40.9 µM 0.285632013642732 0.399561174261839 no 1317 0.387579990582409 1852 17251235
SGTC_2176 5809774 33.9695 µM 0.284810422852573 0.39985815457082 no 1318 0.387894693261817 1938 2870539
SGTC_522 1273-0010 11.6 µM 0.283398507241012 0.400368654753435 no 1319 0.388435686277089 1837 5705015
SGTC_2968 9090663 33.37 µM 0.281561598981576 0.401033072413366 no 1320 0.389139844437612 1814 25236811
SGTC_2939 9044578 71.43 µM 0.280263275776835 0.401502854366211 no 1321 0.38963776192322 1763 2653634
SGTC_1230 0170-0365 3.77 µM 0.280235292738379 0.401512981247444 no 1322 0.389648495643276 1922 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_908 3448-7491 47.7 µM 0.280137032499836 0.401548541518257 no 1323 0.389686186923653 1759 1203031
SGTC_538 2922-0838 53.3 µM 0.279753750613194 0.401687258595992 no 1324 0.389833218514138 1940 777039
SGTC_752 1896-0090 130 µM 0.279294349163607 0.401853541127699 no 1325 0.390009471266375 1791 772567
SGTC_425 3825-7017 13.1 µM 0.278566607657517 0.402116986971693 no 1326 0.390288720935099 1867 3397440
SGTC_550 4123-0385 25.7 µM 0.278403185446593 0.402176152698872 no 1327 0.390351437251904 1804 5731123
SGTC_2472 5377652 49.4 µM 0.277570317205367 0.402477720893715 no 1328 0.390671110245736 1793 1610903
SGTC_517 1365-0151 113 µM 0.27630838601678 0.402934756428819 no 1329 0.391155607720478 1838 768657
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.271577200612952 0.404649433169219 no 1330 0.392973566027633 1776 688664
SGTC_1033 k072-0102 21.3 µM 0.271324006121942 0.404741247900718 no 1331 0.393070922253368 1946 5965931
SGTC_427 1354-0053 47.3 µM 0.271034077825685 0.4048463896812 no 1332 0.393182411268302 1914 6813657
SGTC_318 1488-0629 67.2 µM 0.270825866557362 0.404921901222189 no 1333 0.393262482226379 1806 3662576
SGTC_2754 granisetron 64.02 µM 0.270780833249574 0.404938233822602 no 1334 0.393279801095861 1938 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.268252033867985 0.405855639232397 no 1335 0.394252662453131 1941 77254
SGTC_724 3910-0327 137 µM 0.267974660678831 0.40595629707889 no 1336 0.394359411735873 1791 2885483
SGTC_2741 miltefosine 3.04 µM 0.266377585198583 0.406535991446633 no 1337 0.394974213105021 1862 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3031 9088762 49.47 µM 0.266276565682035 0.406572665649131 no 1338 0.39501310983334 1836 205253
SGTC_1314 1222-0010 41.1 µM 0.264149560680953 0.407345044970325 no 1339 0.395832337866234 1861 3526027
SGTC_699 0375-0592 111 µM 0.26402688254506 0.407389604102456 no 1340 0.39587960212192 2001 762578
SGTC_1518 st038567 90.8 µM 0.262451842783485 0.407961796049712 no 1341 0.396486554107019 1876 77966
SGTC_3356 9151811 4.48 µM 0.262237886791252 0.40803953872001 no 1342 0.396569022854328 1818 1859254 YPR165W RHO1
SGTC_2061 5245884 80.95 µM 0.261865881131598 0.408174718655772 no 1343 0.396712422425075 1825 573863
SGTC_530 4358-1714 28 µM 0.260717919365828 0.408591935439075 no 1344 0.397155023102562 1899 1564641
SGTC_2567 aureobasidin a 60 nM 0.260495273857544 0.408672866036836 no 1345 0.397240880214336 1861 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_3111 9122088 49.47 µM 0.260160904978375 0.408794414871029 no 1346 0.397369829722425 1947 16876704
SGTC_574 1315-0397 40 µM 0.25999617241747 0.408854301214382 no 1347 0.3974333630339 1875 6794277
SGTC_3203 9113543 49.47 µM 0.259488857463881 0.409038742216186 no 1348 0.397629039065311 1878 17018012
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.256568485582962 0.41010087218604 no 1349 0.398755952815949 1857 521171
SGTC_1285 0929-0069 65.5 µM 0.255902846664392 0.410343055568328 no 1350 0.399012928239074 1862 1206237
SGTC_2777 climbazole 1.536 µM 0.253932312380406 0.411060206940799 no 1351 0.399773925550151 1902 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2502 avocadyne acetate 18.59 µM 0.252474047440148 0.411591115865619 no 1352 0.400337335812116 1841 3952079
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.251749442165449 0.411854982392591 no 1353 0.400617369059919 1828 442882
SGTC_310 1273-0058 1.06 µM 0.251462184449525 0.411959598931248 no 1354 0.400728397734627 1918 2734232
SGTC_2117 5521686 200 µM 0.251223116034685 0.412046670154362 no 1355 0.400820806761396 1806 803312
SGTC_1138 3761-0006 1.03 µM 0.248620605652404 0.412994810976829 no 1356 0.401827133938745 1915 12061087
SGTC_1023 4482-3888 16 µM 0.248299094246295 0.413111978650257 no 1357 0.401951499877061 1957 3303168
SGTC_77 0828-0286 12.516 µM 0.246330798045435 0.413829448731302 no 1358 0.402713085456551 1979 745345
SGTC_2596 sinensetin 100 µM 0.244665300388399 0.414436769581837 no 1359 0.403357798912001 1839 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2278 7948257 134.34 µM 0.244247780228686 0.414589049722469 no 1360 0.403519462052353 2035 1247028
SGTC_1098 clofazimine 15.1 µM 0.242280866213985 0.415306605231436 no 1361 0.404281269364998 1955 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3252 9135871 49.47 µM 0.240010661151121 0.416135156369735 no 1362 0.40516099586818 1955 17682838
SGTC_3172 9105863 49.47 µM 0.23904521919975 0.416487624548392 no 1363 0.405535259553637 1945 2348785
SGTC_2417 cerulenin 830 nM 0.238816057899264 0.416571297728341 no 1364 0.405624109030281 1903 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_341 1486-1430 230 µM 0.238282918848557 0.41676597628158 no 1365 0.40583083431806 1829 2054753 YPL210C SRP72
SGTC_2553 4-methylesculetin 85.09 µM 0.237417790114011 0.417081926050254 no 1366 0.406166344855382 1833 5319502
SGTC_1507 4075-3230 155 µM 0.235472054456017 0.417792714788042 no 1367 0.406921183214244 2014 659771
SGTC_2532 xanthone 78.9 µM 0.235433994232035 0.417806621099174 no 1368 0.406935951944871 1963 7020 An insecticide.
SGTC_1545 lovastatin 49.4 µM 0.235052474400291 0.417946025153068 no 1369 0.407084002618477 1909 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_659 k018-0002 107 µM 0.2346765429214 0.418083397356163 no 1370 0.407229897691048 2011 6797879 YHR007C ERG11
SGTC_2855 9016525 58.44 µM 0.234190045224253 0.418261187300784 no 1371 0.407418721460044 1907 43811474
SGTC_1874 staurosporine 7.6 µM 0.232376087224745 0.418924242828894 no 1372 0.408122960130716 1973 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_611 3453-1652 23.7 µM 0.23214711435497 0.419007955627198 no 1373 0.408211876144875 1998 1560575
SGTC_2203 7227154 166.4 µM 0.230997968835791 0.419428140129461 no 1374 0.408658189998444 1959 896304
SGTC_3128 9127691 49.47 µM 0.229673105634087 0.419912689737772 no 1375 0.409172897435973 1909 41316314
SGTC_2933 9026794 32.47 µM 0.227377971740145 0.420752388849151 no 1376 0.410064923864234 1941 17586027
SGTC_3009 9080819 71.4286 µM 0.227264462500252 0.420793926801831 no 1377 0.41010905247052 1877 17027216
SGTC_449 xestospongin c 11.1929 µM 0.227174448739354 0.420826867366935 no 1378 0.410144047627624 1970 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_409 arachidonic acid 100 µM 0.22690747888067 0.420924568332917 no 1379 0.410247843211737 1911 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3062 9077494 49.47 µM 0.226567809290097 0.421048881716558 no 1380 0.410379912914611 1966 16459633
SGTC_2484 5809818 12.04 µM 0.226256119428694 0.421162961914054 no 1381 0.410501112534042 1882 2870548
SGTC_2981 9013952 38.96 µM 0.226037252262779 0.421243072452708 no 1382 0.410586223450095 1780 2996344
SGTC_2728 chlorpromazine 9.18 µM 0.225539707199934 0.421425197792408 no 1383 0.41077971955243 1954 2726 A thorazine and dopamine antagonist.
SGTC_1680 diphenhydramine 100 µM 0.224073841201956 0.421961872591358 no 1384 0.411349923335236 1867 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1737 st035557 69.7 µM 0.223983623484825 0.421994907351106 no 1385 0.411385023044885 1827 5716916
SGTC_1201 1889-3372 45.9 µM 0.223709643821467 0.42209523305298 no 1386 0.411491620718547 1898 5392199
SGTC_3236 9132701 49.47 µM 0.222876311385767 0.422400413250236 no 1387 0.411815886731773 1880 24282524
SGTC_2685 mycophenolic acid 18.85 µM 0.221781639193773 0.42280137118403 no 1388 0.412241936668642 1977 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3198 9112019 49.47 µM 0.221568498303127 0.422879450019128 no 1389 0.412324903835741 1913 45595555
SGTC_2973 9094665 17.96 µM 0.220370406038415 0.423318397450815 no 1390 0.412791345728179 2013 25237061 YIL048W NEO1
SGTC_274 sirtinol 40.1 µM 0.219917940320406 0.423484193003094 no 1391 0.412967531987872 1839 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_307 1501-1223 22.3 µM 0.219006428409459 0.423818236479771 no 1392 0.413322520088695 1933 2830329
SGTC_419 nsc-638432 893 µM 0.218978244619831 0.423828565919745 no 1393 0.413333497389987 1915 368090
SGTC_940 3232-1287 54.8 µM 0.218653061729896 0.423947750168149 no 1394 0.413460157738148 2072 1585493 YIL048W NEO1
SGTC_2223 6903751 107.57 µM 0.217466967182064 0.424382529916491 no 1395 0.413922223684686 1983 5598863
SGTC_1200 1643-0193 18.4 µM 0.217016832449614 0.42454755729529 no 1396 0.41409761356452 2030 5403974
SGTC_1682 st012968 530 nM 0.216569447152597 0.424711589788833 no 1397 0.414271949135621 1831 24207270
SGTC_3189 9110682 49.47 µM 0.215566786353592 0.425079259714181 no 1398 0.414662723865545 1893 17122418
SGTC_3127 9126946 49.47 µM 0.215353168324859 0.425157600644794 no 1399 0.414745989796366 1848 27243249
SGTC_739 1486-1183 203 µM 0.214858278767404 0.425339104674116 no 1400 0.414938906950264 2053 4346692
SGTC_142 0335-0849 62.6745 µM 0.214197280314547 0.425581554920142 no 1401 0.415196608431247 1943 3889043 YPR107C YTH1
SGTC_2293 7624732 200 µM 0.213742520804312 0.425748374311713 no 1402 0.415373925349418 1924 894453
SGTC_2836 9010338 19.48 µM 0.213202030731995 0.425946659520992 no 1403 0.415584692193517 1786 2994051
SGTC_1195 1502-0147 41.1 µM 0.212143380894986 0.42633509201365 no 1404 0.415997588389058 1903 817940
SGTC_2404 5161160 200 µM 0.210526035493058 0.426928655104325 no 1405 0.416628566786566 1937 2831543
SGTC_665 3914-0008 307 µM 0.209011916544238 0.427484484275854 no 1406 0.41721946800519 1904 1069549
SGTC_1255 0566-0045 221 µM 0.207790871999513 0.427932831505089 no 1407 0.417696130075778 1963 2788469
SGTC_50 0929-0078 56.389 µM 0.207173966752644 0.428159384264109 no 1408 0.417936998882746 1988 1377751
SGTC_1465 k213-0056 144 µM 0.206719184976609 0.428326413843045 no 1409 0.418114586784362 1919 24048857 YMR208W ERG12
SGTC_1456 k015-0012 13 µM 0.206672864544015 0.428343426860444 no 1410 0.418132675404445 2098 2989616
SGTC_3086 9117350 49.47 µM 0.206604557327611 0.428368515639887 no 1411 0.4181593504127 2002 2679265
SGTC_1003 4049-0218 100 µM 0.206397312622932 0.428444636992144 no 1412 0.418240284929269 1992 295161
SGTC_1917 st066507 28.5 µM 0.205269542932175 0.428858915415987 no 1413 0.418680769294891 1896 3156428
SGTC_916 4466-0038 42 nM 0.204596832126965 0.429106068449107 no 1414 0.418943565322383 2089 5722064 YGL116W CDC20
SGTC_455 paf C-16 10 µM 0.20445047116741 0.429159844951322 no 1415 0.419000746363827 1940 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2283 7944793 200 µM 0.204026421840105 0.429315658193026 no 1416 0.419166425760332 1889 2970533
SGTC_2364 9055074 200 µM 0.203949846174361 0.42934379643089 no 1417 0.419196346002109 1890 6470630
SGTC_1714 st033236 13.627 µM 0.203681441565732 0.429442426323694 no 1418 0.419301222833923 2000 2916566
SGTC_1032 k061-1018 98.7 µM 0.203610641850883 0.429468443631817 no 1419 0.419328888179965 2084 4005393
SGTC_423 5-fluorouracil 457 µM 0.203001569792452 0.429692276602673 no 1420 0.419566902621108 1813 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_331 k048-0133 24.5 µM 0.202768895412884 0.429777790021421 no 1421 0.41965783537084 1927 6813582
SGTC_41 0478-0632 82.643 µM 0.202639069535183 0.429825505579585 no 1422 0.419708575198834 2107 3750424
SGTC_490 phenamil 164 µM 0.202412846773943 0.429908652818286 no 1423 0.419796992995216 2054 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2405 ticlatone 3.52 µM 0.202291764615318 0.429953157341534 no 1424 0.419844318887461 1816 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2669 eugenol 100 µM 0.200907180686479 0.430462133178155 no 1425 0.420385576409945 2062 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2731 amoxapine 43.43 µM 0.200200257312618 0.430722044243557 no 1426 0.420661982970583 2089 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1596 piperlongumine 63 µM 0.199775224897101 0.430878328290301 no 1427 0.420828189197661 2078 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3177 9107506 49.47 µM 0.197913290636061 0.431563087146951 no 1428 0.421556452717342 2066 8897194
SGTC_3254 9136651 49.47 µM 0.197499947910306 0.431715129131096 no 1429 0.421718161098955 1941 16454030
SGTC_3271 9137798 49.47 µM 0.1971110896155 0.431858174116475 no 1430 0.421870302707669 2049 6498326
SGTC_251 melphalan 456.522 µM 0.196049967771471 0.43224856263666 no 1431 0.42228552808073 2011 460612 A DNA alkylator.
SGTC_1847 st056231 15 µM 0.195798445611623 0.432341107778048 no 1432 0.422383963374204 2013 5393180
SGTC_2773 thioridazine 9.09 µM 0.195422948938822 0.432479275046375 no 1433 0.422530926145637 2082 5452 An antipsychotic.
SGTC_2097 5376186 200 µM 0.194989580957082 0.432638746829292 no 1434 0.422700552130758 2044 742755
SGTC_393 acivicin 6.25 µM 0.194632074713233 0.432770311089904 no 1435 0.422840495615353 1959 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1163 k060-0048 49.9 µM 0.193167790636311 0.433309253295239 no 1436 0.423413781493008 1977 6809982
SGTC_3085 9117376 49.47 µM 0.192825944494543 0.433435090571073 no 1437 0.423547642007962 1975 16480349
SGTC_2692 st077426 47.7 µM 0.192463860450591 0.433568384997613 no 1438 0.423689436927176 2063 25238571
SGTC_302 1094-0063 18.9 µM 0.191584137762871 0.43389226980101 no 1439 0.424033984287946 1953 5440289
SGTC_981 1488-1094 54.9 µM 0.190891360200076 0.434147358845084 no 1440 0.424305354634303 1984 3449522
SGTC_684 1140-0066 328 µM 0.190633504390575 0.434242311469416 no 1441 0.424406369416259 1946 6813534
SGTC_285 1486-1325 46 µM 0.188888012342882 0.434885169608322 no 1442 0.425090294607667 2059 22310230
SGTC_3260 9137109 49.47 µM 0.187240073529925 0.435492257302835 no 1443 0.425736203136318 2085 17478346
SGTC_2658 polymyxin b sulfate 77.05 µM 0.186594955914957 0.435729955051751 no 1444 0.425989110942624 1983 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1405 3909-7894 12 µM 0.186420453649741 0.435794255531073 no 1445 0.42605752693653 2071 7104060
SGTC_826 1683-5028 118 µM 0.185289654351632 0.43621097277066 no 1446 0.426500926081985 1975 722377
SGTC_1466 k213-0079 57.5 µM 0.185114442687508 0.436275547359172 no 1447 0.426569636876927 1968 3657981
SGTC_3162 9099653 49.47 µM 0.185082954373128 0.436287152616792 no 1448 0.426581985532635 2081 25237511
SGTC_1703 st026983 48.3 µM 0.184558037748047 0.43648062269973 no 1449 0.426787850733206 2096 1104023
SGTC_1868 st057644 42.7 µM 0.184493391310326 0.436504450681644 no 1450 0.426813205572213 2035 688665
SGTC_2131 toluylene red 5.2905 µM 0.184243161301585 0.436596684943795 no 1451 0.426911350590515 1926 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_3317 9138495 8.753 µM 0.183551332607051 0.436851709490813 no 1452 0.427182722631005 2110 17020139
SGTC_1739 st037196 92.5 µM 0.183004382902617 0.437053346770978 no 1453 0.427397289818633 2107 612214
SGTC_3120 9124077 49.47 µM 0.182053554973578 0.437403915806891 no 1454 0.427770348648278 2108 18774327 YGL155W CDC43
SGTC_2382 9035899 200 µM 0.181301675842837 0.437681167489353 no 1455 0.428065395347625 1952 6462679
SGTC_1468 k284-1086 134 µM 0.180915449952945 0.437823598266266 no 1456 0.428216970826348 1961 15996457
SGTC_694 1315-0438 43.2 µM 0.178287871474164 0.438792798631403 no 1457 0.429248451690305 2022 6793154
SGTC_2013 4024628 200 µM 0.178260467593469 0.43880290868544 no 1458 0.429259211902352 2024 5230760
SGTC_2688 kanamycin b 96.69 µM 0.177864698091234 0.438948923515292 no 1459 0.429414617785529 1991 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2361 9034121 116 µM 0.177456634227018 0.439099482915005 no 1460 0.429574862721744 1975 6496917
SGTC_601 0986-0029 62.9 µM 0.177389295616791 0.439124329042003 no 1461 0.429601307422474 1996 24747981
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.176407593211886 0.439486577880765 no 1462 0.429986869846726 1942 4174840
SGTC_3024 9090631 49.47 µM 0.174261221361438 0.440278766632418 no 1463 0.430830086887984 2135 25236383
SGTC_1958 st076513 41.9 µM 0.173412524282223 0.44059207219979 no 1464 0.431163590646099 1982 732122 YGL099W LSG1
SGTC_988 1497-1057 103 µM 0.173217734760882 0.440663986081567 no 1465 0.431240142014364 2132 3533044
SGTC_3131 9127911 49.47 µM 0.173083421102241 0.440713574162974 no 1466 0.431292928156967 2022 45595681
SGTC_1362 1611-0397 101 µM 0.172841298915394 0.44080296708251 no 1467 0.431388086852624 1997 27816
SGTC_872 0588-0139 234 µM 0.172138083771104 0.441062615291385 no 1468 0.431664486545955 2096 2047100
SGTC_2682 pyrogallin 40.03 µM 0.172027094613473 0.441103598148704 no 1469 0.431708114049864 2072 822798 An ATP competetive kinase inhibitor.
SGTC_1184 1269-1718 139 µM 0.171154281128122 0.441425907347778 no 1470 0.432051227667472 2098 5403821
SGTC_1635 st007035 42.4 µM 0.169187185791116 0.442152450648934 no 1471 0.432824704374955 2082 3716403
SGTC_1259 0671-0132 43 µM 0.16880412643016 0.442293955686535 no 1472 0.432975356242424 1967 X1259
SGTC_2151 5563267 85.4165 µM 0.168328577161569 0.442469637441152 no 1473 0.433162396643314 1994 5310824
SGTC_732 3970-1727 52.7 µM 0.167151846174812 0.442904404715066 no 1474 0.433625286226382 2126 1275699
SGTC_1192 1488-0095 21.4 µM 0.16556339763073 0.443491398401117 no 1475 0.434250277067741 2013 915875
SGTC_3196 9111891 49.47 µM 0.16520809420984 0.443622713890056 no 1476 0.434390097275971 2115 18891510
SGTC_901 1112-0062 60.1 µM 0.164969121018236 0.443711038733646 no 1477 0.434484143435158 2005 1908457
SGTC_2792 7535235 81.82 µM 0.164010941595288 0.444065211299509 no 1478 0.434861265152835 1950 1281891
SGTC_2666 tannic acid 100 µM 0.162577853714222 0.444595007920404 no 1479 0.435425412576 2071 16134267 A thiamine antagonist.
SGTC_763 3453-1109 128 µM 0.16067894052332 0.445297167315869 no 1480 0.436173138461674 2133 1560353
SGTC_1027 k015-0025 8.67 µM 0.159888510628516 0.44558949457624 no 1481 0.436484449636216 2081 3598955
SGTC_266 formosanin C 406 nM 0.159819508815029 0.445615015147783 no 1482 0.436511627901979 2119 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2786 7743617 45.45 µM 0.157818592002063 0.44635515909437 no 1483 0.437299873977577 1959 583674
SGTC_1857 st056007 79.3 µM 0.155785579861086 0.447107366633808 no 1484 0.43810101872353 2131 619834
SGTC_2760 etidronate 98.04 µM 0.155381979706822 0.447256720037175 no 1485 0.438260094866565 2031 3305 A chelator and antioxidant.
SGTC_2610 ononetin 44.17 µM 0.1549129087984 0.447430310479077 no 1486 0.438444988377135 2000 259632
SGTC_679 0422-0091 41.4 µM 0.153527647962778 0.447943016663944 no 1487 0.438991094418295 2018 627384 YHR062C RPP1
SGTC_2642 cholecalciferol 100 µM 0.152294505417409 0.448399494751612 no 1488 0.439477329206859 2125 9821465 A vitamin D precursor, similar to steriods.
SGTC_410 α-linolenic acid 100 µM 0.151768071603905 0.448594388040975 no 1489 0.439684932769556 2102 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1481 3346-2004 36 µM 0.151057567482108 0.44885744644103 no 1490 0.439965152283409 2144 2770522
SGTC_1469 k284-2957 126 µM 0.150946866566755 0.448898434586331 no 1491 0.440008814920066 2102 23884841
SGTC_119 0121-0043 24.815 µM 0.1501106964272 0.449208052714172 no 1492 0.440338640539846 2154 1092378
SGTC_2879 9041815 71.43 µM 0.149088821203608 0.449586475932133 no 1493 0.440741773346712 2155 4942971
SGTC_3059 1327-0034 3 µM 0.148450568226679 0.449822858550263 no 1494 0.440993597228021 2021 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3245 9134821 49.47 µM 0.146515510300591 0.450539632796666 no 1495 0.441757223297664 2013 17014901
SGTC_1342 1486-1464 234 µM 0.146396700161617 0.45058364712095 no 1496 0.441804116068285 2053 3253938
SGTC_3298 9116858 71.43 µM 0.145613486098342 0.450873811259729 no 1497 0.44211326054982 2108 2506942
SGTC_2464 5717415 7.67 µM 0.144409634010961 0.451319863973854 no 1498 0.442588504855097 1977 5285744
SGTC_2667 digitoxin 100 µM 0.143985704705982 0.451476953430776 no 1499 0.442755878998025 2171 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_924 2046-0044 21.3 µM 0.141395553950531 0.452436912926867 no 1500 0.443778733209316 2181 3623589
SGTC_1000 4048-0884 8.67 µM 0.140203114770124 0.452878947559107 no 1501 0.444249755491975 2074 13040088
SGTC_2784 7567673 72.73 µM 0.140079435129663 0.452924798687166 no 1502 0.444298614382362 2144 3471247
SGTC_1368 1852-0141 284 µM 0.139290616897387 0.453217248025954 no 1503 0.444610252116631 2053 2838987
SGTC_1943 st076331 65.2 µM 0.139190001712079 0.4532545522935 no 1504 0.444650004536966 2185 24208415
SGTC_1624 st003710 6.25 µM 0.138956659576683 0.453341068231528 no 1505 0.444742198673892 2142 24207033
SGTC_962 1254-0300 21.5 µM 0.138814320595828 0.45339384414464 no 1506 0.444798438675618 2059 7340576
SGTC_2783 7738165 71.43 µM 0.138363475927858 0.453561012066779 no 1507 0.444976580656971 2000 17201110
SGTC_422 cantharidin 155 µM 0.138147058476233 0.453641260047791 no 1508 0.445062097503705 1997 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1835 st008666 49.2 µM 0.137453308506752 0.45389851652969 no 1509 0.44533624838676 2014 690455
SGTC_1925 st057770 10.1 µM 0.133262790145092 0.455452852754253 no 1510 0.446992777119468 1922 5989122
SGTC_2729 fluphenazine 10.66 µM 0.133130810377282 0.45550181755301 no 1511 0.447044964431924 2163 3372 An atypical antipsychotic.
SGTC_3199 9111318 49.47 µM 0.133058947756782 0.455528479035506 no 1512 0.447073380665622 2121 8548020
SGTC_1310 1188-0297 994 nM 0.130289876718979 0.456555973154034 no 1513 0.448168544503779 2100 1588352
SGTC_2406 ethylparaben 405.7 µM 0.129301013721539 0.456922972355821 no 1514 0.448559734667356 1811 8434 A possible steroid mimic.
SGTC_2113 5491891 107.031 µM 0.12890218929433 0.457070999480423 no 1515 0.448717522158746 2071 789979
SGTC_547 1120-0019 610 nM 0.128039897671386 0.457391066785065 no 1516 0.449058699551355 2085 3676939
SGTC_837 0091-0265 12.5 µM 0.128010879683812 0.457401838227486 no 1517 0.449070181568851 2042 759367
SGTC_1122 capsaicin 818.572 nM 0.127817848424535 0.457473491997039 no 1518 0.44914656246114 2106 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_21 0849-0113 22.993 µM 0.127731447747366 0.457505564629785 no 1519 0.44918075111394 2111 1560156
SGTC_472 calcifediol 10 µM 0.127390490302426 0.457632133500084 no 1520 0.449315671279355 2090 5283731 A vitamin D metabolite.
SGTC_1824 st053723 68.6 µM 0.126564886491841 0.45793862864651 no 1521 0.449642394954143 2038 675225
SGTC_1459 k035-0031 35.7 µM 0.123969776953279 0.458902192827437 no 1522 0.450669602464603 2036 3877128 YMR208W ERG12
SGTC_1990 st072050 59.8 µM 0.121294460862915 0.459895790472237 no 1523 0.451728903608788 2066 17233948
SGTC_2829 7992743 58.44 µM 0.121161895960448 0.459945030911097 no 1524 0.451781402165914 2235 16462845
SGTC_212 3807-4682 38.772 µM 0.1210907584537 0.459971454765152 no 1525 0.451809574498766 2160 3125501 YBL034C STU1
SGTC_849 0386-0493 241 µM 0.120689175395272 0.460120625129257 no 1526 0.45196861655159 2085 726119
SGTC_1531 st059297 52.4 µM 0.120462190871749 0.460204942335832 no 1527 0.452058514404117 2133 7566702
SGTC_829 1635-0120 117 µM 0.120345159196103 0.46024841641318 no 1528 0.452104866085814 2185 285054
SGTC_2881 9058953 51.95 µM 0.120009412758259 0.460373139698178 no 1529 0.452237845774237 2182 17122249
SGTC_796 1234-0020 70.7 µM 0.118036236458162 0.461106214783946 no 1530 0.453019473012018 2208 46495034
SGTC_1889 st059080 5.18 µM 0.117815946822967 0.461188065107418 no 1531 0.453106746906632 2234 176925 Isolated from Daphnopsis sellowiana.
SGTC_2315 7733312 200 µM 0.117782790480487 0.461200384746211 no 1532 0.453119882914428 2102 726316
SGTC_2377 9073351 62.6 µM 0.117637312110761 0.461254439428365 no 1533 0.45317751970285 2028 7337946 YHR072W ERG7
SGTC_3044 9093193 49.47 µM 0.117474379150855 0.461314980476494 no 1534 0.453242072961886 2062 25236277
SGTC_438 sphingosine 6.67 µM 0.115694268373615 0.461976474868082 no 1535 0.453947424461827 2015 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1419 3993-2473 62.6 µM 0.115216695156073 0.462153960450057 no 1536 0.454136682990437 2120 704026
SGTC_1800 st050079 29.0735 µM 0.114785687829213 0.462314146728815 no 1537 0.454307496762667 2162 3645560
SGTC_3286 9117135 37.221 µM 0.114587407811412 0.462387840658512 no 1538 0.454386080535529 2078 3438150
SGTC_382 3229-0966 23.2 µM 0.113466935476661 0.462804306254156 no 1539 0.454830187711254 2192 5722370
SGTC_2991 9074669 71.4286 µM 0.113374694290046 0.462838592975803 no 1540 0.454866750684418 2169 17333109
SGTC_1070 indatraline 8.81 µM 0.113186624291208 0.462908500820738 no 1541 0.454941299894045 2085 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_825 1988-2224 89.6 µM 0.111734571242151 0.463448284533247 no 1542 0.455516933534183 2121 1180859
SGTC_2049 5262831 67.185 µM 0.11118679164887 0.463651932717265 no 1543 0.455734112711921 2116 763417
SGTC_2025 5147754 141 µM 0.109408189516494 0.464313229562989 no 1544 0.456439369224486 2200 315777 YLR208W SEC13
SGTC_2250 alverine citrate 130 µM 0.108838091998384 0.464525216804184 no 1545 0.456665455110591 2128 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2318 6029776 164 µM 0.107397255785781 0.465061027602228 no 1546 0.457236915741078 2155 818325
SGTC_617 3770-0098 35 µM 0.107286255752138 0.465102308367548 no 1547 0.457280943963388 2114 5962639
SGTC_2868 9035608 32.47 µM 0.106799571240177 0.465283310119724 no 1548 0.457473993815789 2226 6462614
SGTC_2015 5119600 184 µM 0.106416378776763 0.46542582743079 no 1549 0.457625999240483 2195 2828786
SGTC_3039 9090270 49.47 µM 0.106340303489264 0.465454121953367 no 1550 0.457656177650413 2244 17173750
SGTC_1765 st044815 90.4 µM 0.104105804234466 0.466285271888474 no 1551 0.458542692388498 2076 645695
SGTC_1364 1653-0028 37.6 µM 0.102714812116459 0.466802743296481 no 1552 0.459094658728745 2143 5718652
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.102269702983031 0.466968342936593 no 1553 0.459271301353611 2239 688801
SGTC_1332 1480-0653 17.5 µM 0.100877143812457 0.467486471320771 no 1554 0.459823993566704 2247 5749438
SGTC_275 trichlorophene 5.69 µM 0.100359650968558 0.467679028559262 no 1555 0.460029400925113 2150 62616
SGTC_2713 st079149 53.4 µM 0.100268810129557 0.467712830892551 no 1556 0.460065459292695 2136 3103253
SGTC_3329 9141233 27.5565 µM 0.099764039432352 0.467900662843225 no 1557 0.460265828975607 2202 4909101 YNL103W MET4
SGTC_1391 3442-0225 151 µM 0.0995881360539264 0.467966120532372 no 1558 0.460335656527794 2163 5227075
SGTC_313 3474-0040 5.03 µM 0.098115666360801 0.468514094141999 no 1559 0.460920223796296 2205 1043375 YIL048W NEO1
SGTC_1827 berberine 7.24 µM 0.0964059231900156 0.46915044289459 no 1560 0.461599094006432 2069 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3267 9137951 49.47 µM 0.0960016415727996 0.4693009239195 no 1561 0.461759634399901 2088 16643986
SGTC_692 k241-0027 77.8 µM 0.094710278607404 0.469781622145241 no 1562 0.462272476766461 2223 3600480
SGTC_1155 4088-0394 48.2 µM 0.0946295783272833 0.469811663566717 no 1563 0.462304527571948 2089 2326248
SGTC_1773 st048542 73.5835 µM 0.0940235833719105 0.470037256240437 no 1564 0.462545211449555 2094 3237138
SGTC_2133 5320837 200 µM 0.0933644999210272 0.470282622990721 no 1565 0.462806996126259 2221 2841355
SGTC_1065 prochlorperazine maleate 2.48 µM 0.0927085785142805 0.470526823762802 no 1566 0.463067540848567 2244 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2432 5630864 12.22 µM 0.0925322295835668 0.470592480695469 no 1567 0.463137592776113 2157 5714970
SGTC_1571 st070080 73.4 µM 0.0896466323027831 0.471666937252725 no 1568 0.464284013172183 2214 4315245
SGTC_661 1304-0007 33.6 µM 0.0893174599870871 0.471789518319775 no 1569 0.464414809231836 2166 3117130
SGTC_2512 diallyl trisulfide 49.23 µM 0.0885017136709622 0.472093307041317 no 1570 0.464738961186427 2262 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_860 0443-0016 25.1 µM 0.0884689442847868 0.472105510893667 no 1571 0.464751983201226 2259 5337942
SGTC_936 3005-4620 401 µM 0.086651306285012 0.472782469533612 no 1572 0.465474341357558 2268 777207
SGTC_969 1313-0238 134 µM 0.0862020648901207 0.472949796584536 no 1573 0.465652894637464 2181 5212874
SGTC_2715 st079500 56.4 µM 0.0860170977677456 0.473018691898806 no 1574 0.465726412773736 2223 28246688
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0857747801848476 0.473108949949322 no 1575 0.46582272753585 2213 15053
SGTC_414 piperonyl butoxide 100 µM 0.0825532182394267 0.474309041382371 no 1576 0.467103400337597 2178 5794 A potent inhibitor of cytochrome P450.
SGTC_2369 9071472 200 µM 0.0821645940768001 0.474453827049452 no 1577 0.467257914024302 2208 17296037
SGTC_2629 bisabolol 100 µM 0.0804564441222091 0.475090254484828 no 1578 0.467937118219525 2212 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1215 3852-0577 11.2 µM 0.0802692319027435 0.475160010447739 no 1579 0.468011564307294 2237 2884876
SGTC_3116 9124943 49.47 µM 0.0766084981826981 0.476524163682334 no 1580 0.469467499125945 2201 41905195 YPL160W CDC60
SGTC_853 0419-0306 21 µM 0.0754702855269202 0.476948369491768 no 1581 0.469920269403727 2127 762713
SGTC_2964 9083345 53.42 µM 0.07531383732871 0.477006678956915 no 1582 0.469982506077572 2194 17741579
SGTC_3136 9095672 49.47 µM 0.0738599113025314 0.477548591921968 no 1583 0.470560927414083 2289 17217380
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0732216164973723 0.477786512818523 no 1584 0.470814882539953 2273 6708561
SGTC_2442 5158906 48.48 µM 0.0731608316841542 0.477809170439312 no 1585 0.470839067306759 2239 1893835
SGTC_3075 9116269 49.47 µM 0.0699876883177465 0.478992061764434 no 1586 0.472101729453369 2216 17015205 YNL244C SUI1
SGTC_3336 9143619 71.43 µM 0.0698930790404464 0.479027333310598 no 1587 0.472139380892511 2291 45595730
SGTC_690 glyoxal 20.3 µM 0.0686434054568598 0.479493242880586 no 1588 0.472636733884982 2226 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_839 0122-0028 230 µM 0.0685237213410883 0.479537865592937 no 1589 0.47268436877694 2201 759448
SGTC_653 0203-0016 55.2 µM 0.0675432264501634 0.47990344034676 no 1590 0.47307462542127 2231 295302
SGTC_2697 mebhydrolin 72.4 µM 0.0668795009416755 0.480150918143634 no 1591 0.473338816186559 2256 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1088 bifonazole 369 nM 0.0665014335471332 0.480291888407522 no 1592 0.473489308216235 2276 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1049 3226-0134 66 µM 0.0664339946091366 0.480317034672856 no 1593 0.473516153094639 2279 5702385
SGTC_20 0481-0013 4.944 µM 0.0661545960834374 0.480421216112718 no 1594 0.47362737231 2253 182045
SGTC_1789 tunicamycin 25 nM 0.0660912506961183 0.480444836372258 no 1595 0.473652588277823 2262 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1407 3909-7909 12.3 µM 0.0653728879989025 0.480712704596601 no 1596 0.473938555067407 2272 4411780
SGTC_2455 5377712 9.75 µM 0.0631165355839123 0.481554125514323 no 1597 0.474836853530009 2146 2243908
SGTC_2347 9049783 174.81 µM 0.0627518290677658 0.481690136768226 no 1598 0.474982062528046 2252 6467988 YPL169C MEX67
SGTC_3156 9099931 49.47 µM 0.0621269641857444 0.481923174720379 no 1599 0.47523086207727 2238 18111053
SGTC_1358 1509-0022 2.48 µM 0.0616227955446418 0.482111204559715 no 1600 0.475431611609624 2244 3258434
SGTC_1388 3346-4487 254 µM 0.0604939841513423 0.482532209458817 no 1601 0.475881103514326 2242 3345614
SGTC_2353 9059630 146.67 µM 0.0602166935982197 0.482635631577418 no 1602 0.475991525136183 2255 4779114
SGTC_145 3737-0113 38.366 µM 0.0596708333919148 0.482839226554775 no 1603 0.476208900954583 2296 6849351
SGTC_2308 7584454 197.62 µM 0.0582044034089808 0.483386197722505 no 1604 0.476792906628865 2276 893577
SGTC_481 bay k-8644 50 µM 0.058074431179145 0.483434678248246 no 1605 0.476844670486732 2216 2303 A calcium channel antagonist.
SGTC_548 1436-0017 110 µM 0.0579954036322611 0.483464156180521 no 1606 0.476876144868166 2300 9677137
SGTC_2095 5432005 200 µM 0.057575094729416 0.483620936411885 no 1607 0.477043544141284 2295 783734
SGTC_819 1013-0258 27.7 µM 0.0567397991512627 0.483932519114127 no 1608 0.477376234964196 2270 5753198
SGTC_606 k015-0008 38.6 µM 0.0563128303149658 0.484091791212171 no 1609 0.477546298970652 2294 1970475
SGTC_1039 k821-0043 94 µM 0.0549424544873541 0.484602999249071 no 1610 0.478092154574753 2289 15992768
SGTC_1581 himbacine 57.9 µM 0.0547959665065131 0.484657646962279 no 1611 0.478150506919017 2253 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2342 7990637 118.86 µM 0.0539246936231386 0.484982683442827 no 1612 0.478497581309664 2254 2033102 YER133W GLC7
SGTC_1632 st005650 90 µM 0.0534565613019004 0.485157328708987 no 1613 0.478684070095851 2251 2759605
SGTC_1237 0330-0133 46.1 µM 0.0513298839332972 0.485950759682248 no 1614 0.479531327774857 2291 X1237 YHR072W ERG7
SGTC_2264 7948757 110.76 µM 0.0504790195864219 0.486268219980241 no 1615 0.479870334015638 2320 2971411
SGTC_2571 chrysanthemic acid 100 µM 0.0497601294111508 0.486536447069448 no 1616 0.480156769710151 2200 2743 An insecticide.
SGTC_904 1141-0088 396 µM 0.0493740139747606 0.48668051418317 no 1617 0.480310618370784 2185 1378119
SGTC_2396 5342950 42.78 µM 0.0488687746884795 0.486869031324584 no 1618 0.480511936653503 2258 1886677
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0485780678049825 0.486977502509284 no 1619 0.48062777434079 2263 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3185 9108267 49.47 µM 0.0469584233551446 0.487581856324781 no 1620 0.481273182152895 2247 4910486
SGTC_3096 9117468 49.47 µM 0.0469509687086655 0.487584638017115 no 1621 0.481276152849943 2325 41316311
SGTC_3224 9130643 49.47 µM 0.0465949594522465 0.48771748314214 no 1622 0.481418024721619 2290 17644395
SGTC_65 0798-0905 34.986 µM 0.0461637625937504 0.487878386401665 no 1623 0.481589862463529 2316 3602145
SGTC_456 gingerol 170 µM 0.0460531062897292 0.487919678672899 no 1624 0.481633961040333 2286 442793 A herb.
SGTC_771 0250-0039 27.3 µM 0.0459569421243144 0.487955563193675 no 1625 0.481672284415308 2251 3005115
SGTC_2150 5556613 200 µM 0.0456319525551738 0.488076836685979 no 1626 0.481801800617085 2286 743190
SGTC_2157 5649910 96.377 µM 0.0444227711381734 0.488528065847509 no 1627 0.482283705409831 2309 2858091
SGTC_1397 3532-0190 20.1 µM 0.0444150913628513 0.488530931750023 no 1628 0.482286766175911 2293 5322280
SGTC_1470 k295-0292 231 µM 0.043224051405205 0.488975405527945 no 1629 0.482761466376842 2318 5045612
SGTC_324 1315-0088 19.6 µM 0.0428842319752981 0.489102222301582 no 1630 0.48289690912395 2322 6787421
SGTC_2101 5377231 179.231 µM 0.0427023735074918 0.489170090281428 no 1631 0.482969393755964 2272 2844213
SGTC_1738 st035555 74 µM 0.0425183411752873 0.489238769847556 no 1632 0.483042745413707 2302 5331140
SGTC_2126 5251174 33.877 µM 0.0423595713945175 0.489298021864443 no 1633 0.483106028378006 2324 790722
SGTC_2523 spermine 47.74 µM 0.0413186589433798 0.489686490508527 no 1634 0.483520929043073 2329 1103 A DNA binding polyamine.
SGTC_1900 st060200 72.8 µM 0.041264574182945 0.489706675217781 no 1635 0.483542487354463 2332 688945
SGTC_1052 3253-3998 198 µM 0.0406194166363231 0.489947453332599 no 1636 0.483799652346505 2324 5450317
SGTC_435 c-PAF 6.7 µM 0.0401419675345742 0.490125643636868 no 1637 0.483989971747419 2333 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2785 7756463 72.73 µM 0.0393641383822875 0.490415943943913 no 1638 0.484300035580819 2319 2201551
SGTC_529 4076-0302 30.3 µM 0.0386122616345682 0.490696563158134 no 1639 0.484599763106618 2237 5816522
SGTC_2673 kobusone 100 µM 0.036479451420412 0.491492605888655 no 1640 0.48545003159675 2345 6710676 An epoxy ketone and protein crosslinker.
SGTC_3065 9113888 49.47 µM 0.0362373034766926 0.491582986553375 no 1641 0.485546570819159 2310 16648368
SGTC_2412 st077135 33.4 µM 0.0360001485789969 0.491671504004318 no 1642 0.485641120241705 2294 13258915
SGTC_856 0433-0016 11.3 µM 0.0357787949442388 0.491754124044969 no 1643 0.485729370711351 2252 3911780
SGTC_922 1866-0035 480 µM 0.0353520234332557 0.491913417114492 no 1644 0.485899520264883 2239 3156169
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0353098716892287 0.491929150382904 no 1645 0.485916325885468 2251 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_668 1682-0499 62.6 µM 0.0348401765801275 0.492104466374325 no 1646 0.486103591893541 2302 682214
SGTC_681 1642-0006 26.6 µM 0.0347369924293531 0.492142980567615 no 1647 0.486144731511879 2349 4446530
SGTC_1354 1498-1681 81 µM 0.0339273810449934 0.492445176093584 no 1648 0.486467529418121 2292 5754243
SGTC_1750 st081859 2.357 µM 0.0336001099269908 0.492567334543676 no 1649 0.486598017304987 2329 5291695
SGTC_2755 lomerizine 42.69 µM 0.0335425488549711 0.492588820078616 no 1650 0.486620967913613 2332 3949 A calcium channel blocker.
SGTC_1153 4055-0057 267 µM 0.032976086424833 0.492800261828454 no 1651 0.486846828768054 2335 882706
SGTC_2273 7815444 169.05 µM 0.0318180432973523 0.493232527379796 no 1652 0.487308578725344 2343 2824616
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0317214135344562 0.493268596970688 no 1653 0.487347108973795 2309 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_556 4058-0063 51.5 µM 0.0307521835529931 0.493630390452486 no 1654 0.487733587181056 2320 6615692
SGTC_1148 3909-7663 27.7 µM 0.0298499988162544 0.493967162047359 no 1655 0.488093341611796 2354 4084526
SGTC_1562 morin hydrate 59.1 µM 0.0274526655758333 0.494862069680072 no 1656 0.489049346500584 2324 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2155 5570423 76 µM 0.0266688004644854 0.495154686840178 no 1657 0.489361948949904 2325 797402
SGTC_1893 st059353 36.1 µM 0.0266023981644034 0.495179474967385 no 1658 0.489388430239607 2248 3112488
SGTC_1401 3807-4679 7.6 µM 0.0261954686671777 0.495331383062232 no 1659 0.489550715061775 2358 3291456
SGTC_2481 5478948 45.16 µM 0.0261043656102791 0.495365392220971 no 1660 0.489587047498519 2335 77792
SGTC_3320 9137005 35.139 µM 0.0255953992328668 0.495555392147862 no 1661 0.489790027874841 2246 4908713
SGTC_1554 st069299 38.7 µM 0.0244840066534422 0.495970284509741 no 1662 0.490233270366731 2321 24207999
SGTC_2588 indole-3-carbinol 100 µM 0.0224800232852535 0.496718399364168 no 1663 0.491032523541332 2366 3712 Induces cell cycle arrest.
SGTC_304 1310-0298 97 µM 0.0223721645243791 0.496758664890071 no 1664 0.491075542142309 2364 1550234
SGTC_629 3448-6466 76.7 µM 0.0217742993426616 0.49698185880717 no 1665 0.491313997739579 2357 573744
SGTC_2231 micatex 6.853 µM 0.0213223433317186 0.497150582814937 no 1666 0.491494260244175 2327 20737 An antifungal of unknown mechanism.
SGTC_1428 4049-0204 61.7 µM 0.0211888983775391 0.497200400521974 no 1667 0.491547485053584 2369 X1428
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0210379274966673 0.497256761065384 no 1668 0.491607700298258 2244 61125 An anti-inflammatory.
SGTC_1674 st016616 23.6 µM 0.0190063133172906 0.49801520940965 no 1669 0.492418034510725 2370 625830
SGTC_3222 9128301 49.47 µM 0.0188703826772409 0.498065955733415 no 1670 0.492472253266252 2365 4911358
SGTC_609 0986-0026 86.3 µM 0.0184507654061495 0.498222609599184 no 1671 0.492639627192287 2372 2848610
SGTC_895 0964-0006 13.7 µM 0.0184107701494355 0.498237540866725 no 1672 0.492655580281396 2369 6738897
SGTC_2905 7799065 20.05 µM 0.018161589221667 0.498330566630161 no 1673 0.492754972469709 2372 1296806
SGTC_1487 3970-0795 2.82 µM 0.0164285872271864 0.498977543874774 no 1674 0.493446236757593 2333 3765103
SGTC_909 3448-9333 149 µM 0.0156817716102241 0.49925635158587 no 1675 0.493744134679074 2374 3344074
SGTC_1409 3909-8004 61.9 µM 0.0155947134503522 0.499288852922662 no 1676 0.493778861613314 2361 2119279
SGTC_759 3486-0358 89.3 µM 0.0148176182247766 0.499578965299134 no 1677 0.494088841906843 2385 875103
SGTC_582 0987-0078 156 µM 0.0138083054145591 0.499955771601522 no 1678 0.494491458201626 2381 1625765
SGTC_2488 5268135 45.7 µM 0.0135713652162746 0.499955771601522 no 1679 0.494585974807259 2372 1270356 YLR208W SEC13
SGTC_3047 9092122 49.47 µM 0.0122611889593929 0.4994666441399 no 1680 0.49510861587555 2376 17173831
SGTC_2555 cholic acid 100 µM 0.0119766149139597 0.499360404331229 no 1681 0.495222136157253 2350 6708657 Influences liver metabolism.
SGTC_3249 9135183 49.47 µM 0.0114922096586911 0.499179561799649 no 1682 0.495415372588097 2375 4902779
SGTC_1106 tegaserod maleate 11.7 µM 0.0114740204756696 0.499172771253116 no 1683 0.495422628543843 2317 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2291 7917025 104.35 µM 0.0102621984005977 0.498720363764716 no 1684 0.495906047025811 2381 2964612
SGTC_1656 st012921 11 µM 0.00884533207470113 0.49819140958094 no 1685 0.496471269065863 2387 6732821
SGTC_2823 7987624 58.44 µM 0.00639643030734762 0.497277176928553 no 1686 0.497448210907556 2380 2239440
SGTC_1130 3454-2858 15.9 µM 0.0052885930119387 0.496863599608459 no 1687 0.497890166478772 2379 715628 YIL048W NEO1
SGTC_344 k064-0035 6.43 µM 0.00500513681645368 0.496757780393109 no 1688 0.498003247641631 2393 5088750
SGTC_2805 7950783 58.44 µM 0.00414275096873637 0.496435837924673 no 1689 0.498347286208817 2398 1178958 YDL195W SEC31
SGTC_314 1671-0008 2.74 µM 0.00403763188474501 0.496396595439171 no 1690 0.498389222305089 2399 3913060
SGTC_271 rotenone 740 µM 0.00366065853151023 0.496255866083824 no 1691 0.498539611799305 2375 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_76 0433-0009 400.328 µM 0.00198225392371743 0.495629300380161 no 1692 0.499209195617226 2382 2841569
SGTC_158 k038-0087 26.446 µM 0.00143621382460812 0.495425460244245 no 1693 0.499427033778644 2398 X158
SGTC_970 1315-0089 19.5 µM 0.00131239296835235 0.495379237319336 no 1694 0.49947643110672 2400 6811083 YLR033W RSC58
SGTC_1336 1486-0901 104 µM 0.000439784843941387 0.495053490277832 no 1695 0.499824551237128 2402 5006114
SGTC_3091 9116372 49.47 µM 0.000194453669080406 0.494961908052068 no 1696 0.499922424210314 2400 17169793
SGTC_474 dl-dihydrosphingosine 5 µM -0.000177936050147 0.494822895329851 no 1697 0.499929013786763 2409 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1390 3413-2614 145 µM -0.000601766706034474 0.494664680521583 no 1698 0.499759929832514 2408 3421432
SGTC_365 0121-0052 13.6 µM -0.00157357010195388 0.494301912218101 no 1699 0.499372236614225 2412 3101739
SGTC_2295 7971645 200 µM -0.00161326603786223 0.494287094064533 no 1700 0.499356400247136 2410 2978226 YKL099C UTP11
SGTC_2165 5727197 32.143 µM -0.0022278138769026 0.494057689627421 no 1701 0.499111231586821 2422 1361712
SGTC_828 2074-0507 139 µM -0.00309021459392761 0.493735767571235 no 1702 0.498767184705082 2418 X828
SGTC_2413 inermin 26.06 µM -0.00346905491202946 0.493594353086959 no 1703 0.498616050098379 2413 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3110 9122132 49.47 µM -0.00367806550545431 0.493516333420749 no 1704 0.498532667468175 2432 918317
SGTC_2733 amorolfine 100 µM -0.00520203445218973 0.492947472579265 no 1705 0.497924697872935 2415 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1649 st011737 51.3 µM -0.00579414064496536 0.492726457427399 no 1706 0.497688485251859 2422 1761035
SGTC_822 1487-0950 154 µM -0.00601467823218498 0.492644138050988 no 1707 0.497600505017677 2413 1958375
SGTC_2114 5491910 81.25 µM -0.00607537569859452 0.492621481752094 no 1708 0.497576290674445 2428 2849228
SGTC_2533 agelasine 13.65 µM -0.00628140841438674 0.492544576927803 no 1709 0.497494097081899 2418 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_734 2023-0417 80 µM -0.00741758531562989 0.492120486786842 no 1710 0.497040838734926 2424 3935732
SGTC_2204 7233102 200 µM -0.0074188625392998 0.492120010054413 no 1711 0.497040329210423 2423 2172480
SGTC_3148 9097893 49.47 µM -0.00769153260051447 0.492018234356726 no 1712 0.496931552699322 2423 17174100
SGTC_3040 9091894 49.47 µM -0.00919506965685678 0.491457039853709 no 1713 0.496331749634053 2425 25236966
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.00979715097991148 0.491232317960721 no 1714 0.496091564771387 2420 4000243
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0102188420476963 0.491074926897044 no 1715 0.495923342801193 2425 140250 A respiratory chain inhibitor.
SGTC_2797 7859098 81.82 µM -0.0113417703183614 0.490655814417167 no 1716 0.495475385290149 2434 972681
SGTC_2021 4019055 173 µM -0.0124322427084786 0.49024882537152 no 1717 0.495040380504047 2428 44827708 YER133W GLC7
SGTC_573 3702-0553 84.7 µM -0.0148102881963407 0.489361320611089 no 1718 0.494091765844251 2437 1222756
SGTC_2001 4023502 57.655 µM -0.0148535460726622 0.489345176915342 no 1719 0.494074510346514 2448 108941 YCR052W RSC6
SGTC_942 3253-1115 227 µM -0.0151714421368008 0.489226539697425 no 1720 0.493947702456758 2447 46497897
SGTC_193 1273-0060 1.558 µM -0.0155851720045166 0.489072139213434 no 1721 0.493782667636926 2434 2847393 YHR072W ERG7
SGTC_637 1181-0519 7.26 µM -0.0166211050407414 0.488685545009285 no 1722 0.493369443747824 2440 6252091 YGR060W ERG25
SGTC_1821 st053465 65.6 µM -0.0183967462054496 0.488022928087063 no 1723 0.492661174078205 2454 675086
SGTC_1146 3579-1023 7 µM -0.0201977110265144 0.487350894901905 no 1724 0.491942826925228 2484 X1146
SGTC_755 1995-0008 37.3 µM -0.020425827819021 0.487265775243385 no 1725 0.491851840263052 2433 689533
SGTC_1515 3460-0031 42.1 µM -0.0208649167990897 0.487101934912461 no 1726 0.491676706433197 2450 2876596
SGTC_1955 wogonin 32.4 µM -0.0212664687851041 0.486952102926741 no 1727 0.491516545909905 2480 5281703 A flavanone.
SGTC_2995 9067767 71.4286 µM -0.0214769580412388 0.486873563336816 no 1728 0.491432592021382 2459 11673567
SGTC_921 1561-0023 372 µM -0.0225849054292539 0.486460164793254 no 1729 0.490990692240123 2447 24050882
SGTC_950 1165-0508 94.1 µM -0.022807696809982 0.486377038371858 no 1730 0.490901834228135 2464 6148369
SGTC_3258 9138477 49.47 µM -0.0228583058031433 0.486358155567118 no 1731 0.490881649423316 2448 4970355
SGTC_3348 9149464 3.537 µM -0.0240454017211846 0.485915245118883 no 1732 0.490408196913354 2438 1951442
SGTC_687 k029-0044 34.9 µM -0.0260383780265008 0.48517169667784 no 1733 0.489613363790337 2447 5829338
SGTC_1073 triclabendazole 3.09 µM -0.0260464066418584 0.485168701428932 no 1734 0.489610161922166 2470 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_493 zm226600 134 µM -0.0269809048345606 0.484820072392795 no 1735 0.489237482110815 2491 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1919 st067113 52.3 µM -0.0275411351323027 0.484611075342423 no 1736 0.489014065594099 2485 1268243
SGTC_2775 cyproheptadine 69.59 µM -0.0276779341932155 0.484560042326542 no 1737 0.488959511461723 2450 2913 A selective serotonin reuptake inhibitor.
SGTC_2963 9082507 9 µM -0.0284281286902504 0.484280186095836 no 1738 0.488660344906444 2508 16459611
SGTC_3274 9138298 49.47 µM -0.0294515339916411 0.483898422482121 no 1739 0.488252236213661 2446 17015756
SGTC_3061 glucosamine 200 µM -0.0305380756006645 0.483493123124946 no 1740 0.48781896379662 2441 91431 and experimental redox chemotherapeutic
SGTC_2229 7354935 190 µM -0.0315090932181617 0.48313093069218 no 1741 0.487431770203744 2454 318112
SGTC_1239 0337-0584 35.4 µM -0.0325737878040589 0.48273381248475 no 1742 0.487007236518283 2491 914301 YML130C ERO1
SGTC_211 3455-0679 143.504 µM -0.0326323223639073 0.48271198029482 no 1743 0.486983897015265 2491 748649
SGTC_3036 9090181 49.47 µM -0.0328158031131084 0.482643546075881 no 1744 0.486910737969065 2460 25236586
SGTC_155 k072-0202 43.6 µM -0.0335788958958996 0.482358935030567 no 1745 0.486606475705965 2451 5857737
SGTC_3218 9131285 49.47 µM -0.034035860327765 0.482188505103126 no 1746 0.486424277425539 2482 17156417
SGTC_210 3551-0445 56.827 µM -0.0341243884406284 0.482155487941935 no 1747 0.486388980322274 2506 2865180 YOR207C RET1
SGTC_2416 tofa 880 nM -0.0343083332510775 0.482086884866684 no 1748 0.486315639904787 2507 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_790 1575-0012 79.1 µM -0.0348077401183485 0.481900631426331 no 1749 0.48611652432556 2461 378741 YLR208W SEC13
SGTC_778 3456-2434 196 µM -0.0349485146075672 0.481848130391423 no 1750 0.486060397578878 2533 5539063
SGTC_971 1315-0384 26.7 µM -0.0351076815507219 0.481788770375987 no 1751 0.485996938098987 2481 6769120
SGTC_2394 5221648 200 µM -0.0352110012663616 0.481750238345339 no 1752 0.485955744964957 2502 788586
SGTC_2034 5197015 53.07 µM -0.0360586325186384 0.481434129413002 no 1753 0.485617803664196 2494 780676
SGTC_1193 1488-0126 41.5 µM -0.0369976961129095 0.481083936060071 no 1754 0.485243421359963 2501 1384710
SGTC_1871 st057448 67.3 µM -0.0371281817943599 0.481035276800296 no 1755 0.485191400846242 2504 691747
SGTC_1839 st053978 48 µM -0.0378837266960022 0.480753533029985 no 1756 0.484890193975257 2464 3788398
SGTC_367 0335-0881 7.1 µM -0.0395184293891053 0.480143983155742 no 1757 0.484238530232702 2486 23828853
SGTC_1394 3474-0001 65.7 µM -0.0397769407135174 0.480047593362231 no 1758 0.484135480161765 2520 5017666 YIL048W NEO1
SGTC_2874 9043904 71.43 µM -0.0400737339275417 0.479936931035594 no 1759 0.484017171132398 2541 4463428
SGTC_157 1348-1695 65.819 µM -0.0403712576046987 0.479825997900508 no 1760 0.483898572334893 2484 5380510
SGTC_776 4476-4378 112 µM -0.0412937165624318 0.479482064608721 no 1761 0.48353087112819 2556 2892008
SGTC_3229 9132204 49.47 µM -0.0413124439273804 0.479475082380326 no 1762 0.483523406360467 2476 17682924
SGTC_1873 rapamycin 2 nM -0.0421040853591392 0.479179936057322 no 1763 0.483207861707528 2500 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1194 1488-0194 225 µM -0.0424520384473995 0.479050212903674 no 1764 0.483069172514054 2476 1391452
SGTC_1408 3909-7976 48.8 µM -0.0438285683870487 0.478537039734462 no 1765 0.482520527339643 2501 24152374
SGTC_744 1594-0068 283 µM -0.0445725390276237 0.478259700719538 no 1766 0.482224015789757 2487 668392
SGTC_2756 carbadox 75.1 µM -0.0455760821179583 0.47788561441678 no 1767 0.481824066531165 2513 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1556 plumbagin 1.48 µM -0.0462276140390861 0.477642756165098 no 1768 0.481564416588093 2490 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3300 9124615 50.48 µM -0.0465263458501247 0.477531406777804 no 1769 0.481445367933844 2554 24824903
SGTC_2511 berberine 10.47 µM -0.0465550774120596 0.477520697458881 no 1770 0.481433918106104 2499 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2806 7952793 58.44 µM -0.0469058645173364 0.477389947403705 no 1771 0.481294127015946 2554 2972490
SGTC_2931 9014674 55.67 µM -0.0470343129231014 0.477342071006305 no 1772 0.481242940011334 2479 2996810
SGTC_2544 sphondin 68.51 µM -0.0515127964634708 0.475673021339569 no 1773 0.479458452643317 2529 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_559 1550-0661 158 µM -0.0515273815635715 0.475667586418352 no 1774 0.47945264174733 2556 5830875
SGTC_2253 7938677 135.83 µM -0.0521736333558597 0.475426774832587 no 1775 0.479195170922755 2589 2301972
SGTC_2883 9059145 45.46 µM -0.0525803712487273 0.475275217456012 no 1776 0.479033128403578 2491 16476510
SGTC_966 1300-0360 30.2 µM -0.0529986545537998 0.475119361796154 no 1777 0.478866489859586 2531 70588
SGTC_808 0711-0032 135 µM -0.0535466296423603 0.474915187719029 no 1778 0.478648189416295 2485 4252555
SGTC_1132 3456-3614 2.5 µM -0.0537398473562986 0.474843196875027 no 1779 0.47857121752775 2569 3125502
SGTC_2051 5263410 176 µM -0.0538200774692297 0.474813304238261 no 1780 0.478539256597036 2493 227584
SGTC_608 k048-0125 159 µM -0.0539520702363242 0.474764125856976 no 1781 0.478486675497122 2499 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_880 0833-0487 87.2 µM -0.0555458016585349 0.474170357739631 no 1782 0.477851820900819 2493 76075
SGTC_1901 st060216 58.6 µM -0.0564235495952393 0.473843364232634 no 1783 0.477502198486041 2506 688792
SGTC_2159 5658611 73.75 µM -0.0577092699047917 0.473364417830532 no 1784 0.476990104843942 2503 793844
SGTC_2339 9000433 200 µM -0.0587959944138427 0.472959629772603 no 1785 0.476557299468918 2560 2988954
SGTC_2397 5161689 200 µM -0.0591970145205897 0.472810263021227 no 1786 0.47639759377093 2560 2259942
SGTC_2576 guaiol 23.12 µM -0.0598085251292398 0.472582502873618 no 1787 0.476154067831323 2604 227829
SGTC_3077 9117319 49.47 µM -0.0598140328360995 0.472580451541607 no 1788 0.476151874500898 2510 17154678
SGTC_2891 9063876 19.48 µM -0.0600703584537075 0.472484984494767 no 1789 0.476049798921776 2508 6472478
SGTC_3235 9132602 49.47 µM -0.0606042740411661 0.472286135693142 no 1790 0.475837184795369 2589 4912240
SGTC_2942 9052777 62.25 µM -0.0618095415736186 0.471837277464848 no 1791 0.47535725247073 2534 6469503
SGTC_2258 7960471 200 µM -0.0634801246209412 0.471215188596675 no 1792 0.474692092786812 2572 2974708
SGTC_879 0831-1030 162 µM -0.0639378810758894 0.471044742222165 no 1793 0.474509844617757 2531 1549252
SGTC_1659 st012954 42.1 µM -0.0639800162807941 0.471029053374901 no 1794 0.474493069449627 2599 24207262
SGTC_394 menadione 8.33 µM -0.0656293775730943 0.470414956951514 no 1795 0.473836449803296 2504 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1315 1237-0019 3.69 µM -0.0673649159334991 0.469768850744841 no 1796 0.473145599373925 2526 825140
SGTC_504 lovastatin 124 µM -0.0695952800257322 0.468938647917328 no 1797 0.472257896913485 2532 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3038 9091290 49.47 µM -0.0704013594542189 0.468638636028242 no 1798 0.471937104623615 2563 25236843
SGTC_2774 tamoxifen 10.92 µM -0.0707669462101241 0.468502575429213 no 1799 0.471791619474535 2518 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_220 paclitaxel 373.376 µM -0.0715177661997328 0.468223153945703 no 1800 0.471492842689941 2588 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2575 plumbagin 510 nM -0.0720744257514806 0.468016000355798 no 1801 0.471271339287645 2532 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2518 prenyletin 46.28 µM -0.0723989009251637 0.467895255144875 no 1802 0.471142229717925 2549 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2762 leflunomide 42.06 µM -0.0732984298322128 0.467560533742087 no 1803 0.470784320576636 2548 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_204 PMA1.184 62.41 µM -0.0734352554821792 0.467509621902982 no 1804 0.47072988175096 2515 2252213 YGL008C PMA1
SGTC_1731 st035964 63 µM -0.0740811497206943 0.467269296497843 no 1805 0.470472907192367 2595 6739575
SGTC_2853 9015042 58.44 µM -0.0745255815145902 0.467103938498788 no 1806 0.470296093328588 2539 6457456
SGTC_912 3474-0017 2.18 µM -0.0746707359040708 0.467049932701417 no 1807 0.470238346007844 2628 3360550
SGTC_1031 k035-0009 16 µM -0.0747047860237005 0.467037264182584 no 1808 0.470224799810327 2579 5180959
SGTC_1949 st076024 69.1 µM -0.0752694031281839 0.466827200416856 no 1809 0.470000182585242 2513 2921930
SGTC_2 0422-0095 29 µM -0.0764184907539818 0.466399715091656 no 1810 0.469543079562788 2474 6790840
SGTC_2716 st080858 38.6235 µM -0.0804696350790566 0.46489291472344 no 1811 0.467931872796855 2574 5296050
SGTC_2358 9037157 4 µM -0.081243920963192 0.46460498006526 no 1812 0.467623985530562 2619 2388925
SGTC_477 mead ethanolamide 10 µM -0.0814585835911774 0.464525156480895 no 1813 0.467538630441327 2537 16061185
SGTC_1301 naphtanilide LB 4.81 µM -0.0822940284504152 0.464214504924984 no 1814 0.467206451460776 2600 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1704 st028805 70.8 µM -0.0824867538177322 0.464142845074194 no 1815 0.467129825679888 2578 2876101
SGTC_3157 9099274 49.47 µM -0.0836847209705474 0.463697438723501 no 1816 0.466653552714064 2573 17217662
SGTC_1725 st036284 20.55 µM -0.0852919452173273 0.463099941413011 no 1817 0.466014647492412 2662 707914
SGTC_1962 st076595 64.5 µM -0.0864294358122141 0.462677121226838 no 1818 0.465562524040268 2559 279619
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.086866732328907 0.46251458356631 no 1819 0.465388721642903 2597 676296 Flavone; oxidizing agent.
SGTC_1961 st076550 68.7 µM -0.0871741543750861 0.462400322371493 no 1820 0.465266541476294 2651 1579337
SGTC_1021 4476-0760 85.3 µM -0.0877465116159977 0.462187599569675 no 1821 0.465039075620705 2566 746768
SGTC_2540 epiandrosterone 100 µM -0.0886674876477275 0.461845331525672 no 1822 0.464673085915162 2570 441302 A steroid.
SGTC_2674 ligustilide 100 µM -0.0890508527496319 0.461702867485169 no 1823 0.464520747983392 2636 5319022 A signalling regulator.
SGTC_2907 7721985 69.9 µM -0.0892032344837904 0.461646241583051 no 1824 0.46446019744072 2604 3267881
SGTC_2447 5741742 33.78 µM -0.0897934460665387 0.461426923015783 no 1825 0.464225678216678 2635 1776504
SGTC_3239 9133757 49.47 µM -0.09001047062885 0.461346281126307 no 1826 0.464139447123591 2561 17036923
SGTC_413 propylparaben 100 µM -0.0902850254477825 0.461244264447425 no 1827 0.464030359755735 2568 7175 A pharmaceutical preservative.
SGTC_1747 st037496 66.6 µM -0.0905352654529507 0.461151284675757 no 1828 0.463930935615368 2584 723305
SGTC_628 1636-0253 16 µM -0.0933270031024456 0.460114125152656 no 1829 0.46282189016195 2627 4456143
SGTC_2123 5259487 200 µM -0.0960110625658104 0.459117224932204 no 1830 0.461755893248762 2634 2173474
SGTC_75 0159-0059 199.013 µM -0.0972299515076623 0.458664595657695 no 1831 0.461271891430396 2680 5377270
SGTC_885 0865-0106 16.8 µM -0.0975285044869072 0.458553737414177 no 1832 0.461153349409067 2580 2793380
SGTC_3294 9122953 26.2835 µM -0.0977939572010994 0.458455172618273 no 1833 0.461047952919501 2577 16459826
SGTC_2572 astragaloside iv 100 µM -0.0978899358518823 0.458419535577095 no 1834 0.461009845815471 2753 45006101 An anti-inflammatory agent.
SGTC_2267 7931562 200 µM -0.0983074569187266 0.458264513166457 no 1835 0.460844078550724 2547 934880
SGTC_2319 6033012 152.6 µM -0.098758212141235 0.458097158292208 no 1836 0.46066512405728 2615 847246
SGTC_1797 st048695 56.8 µM -0.0991874895352728 0.457937784538786 no 1837 0.460494703889534 2581 592262 YIL048W NEO1
SGTC_721 1187-1332 279 µM -0.100097204084472 0.457600065814052 no 1838 0.460133577501608 2553 25730
SGTC_764 1951-2361 146 µM -0.101933145957525 0.456918591711001 no 1839 0.459404870155228 2600 5438930
SGTC_928 2764-0428 58.7 µM -0.102947797942682 0.456542022324006 no 1840 0.459002200963716 2711 662578
SGTC_360 0957-0399 1.01 µM -0.103000993784013 0.456522280741457 no 1841 0.458981091112234 2691 6752301 YPR165W RHO1
SGTC_787 4152-0075 138 µM -0.103452648854827 0.456354670729374 no 1842 0.458801864258828 2630 9566539
SGTC_1621 st003705 32.4 µM -0.103589879755889 0.456303745631117 no 1843 0.458747409619116 2637 24207032
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.104429712977836 0.455992107079474 no 1844 0.458414172020244 2687 6708739 YPR165W RHO1
SGTC_3280 9140961 49.47 µM -0.105544711659792 0.455578404205199 no 1845 0.457971796656914 2576 4901226
SGTC_3142 9086498 49.47 µM -0.105917783165309 0.455439992571807 no 1846 0.457823792254733 2627 25236367
SGTC_2487 5918373 44.05 µM -0.106190361144732 0.455338868022054 no 1847 0.457715659198952 2578 2876279
SGTC_1042 0350-0096 82 µM -0.106321569132805 0.45529019179503 no 1848 0.457663609445391 2564 3122515
SGTC_2280 7785178 200 µM -0.108024700998535 0.454658416175603 no 1849 0.456988049148529 2619 2954328
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.109408079676527 0.454145337116675 no 1850 0.456439412782812 2907 5282309
SGTC_933 2914-0560 114 µM -0.109788532794868 0.454004244858805 no 1851 0.456288542784824 2652 463887
SGTC_1628 st004252 77.7 µM -0.111512042403553 0.453365148764567 no 1852 0.455605158350566 2714 692968
SGTC_2120 5538279 151.968 µM -0.111825301065832 0.453249001968889 no 1853 0.455480962996373 2627 2058197
SGTC_1454 4239-0054 42.6 µM -0.112480106684158 0.45300623286559 no 1854 0.455221371102124 2782 1340767
SGTC_36 0335-0881 14.2 µM -0.112624819097323 0.452952583122555 no 1855 0.455164003721903 2602 23828853
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.112755708951025 0.452904058605353 no 1856 0.455112116732318 2677 551469
SGTC_1764 st044502 93.5 µM -0.113080513059527 0.452783647708227 no 1857 0.454983362106176 2694 8407
SGTC_2194 5927483 104.545 µM -0.114689662161962 0.452187170591009 no 1858 0.454345554127501 2587 760979
SGTC_816 0325-0417 81.3 µM -0.114753154048735 0.452163637711951 no 1859 0.454320390663626 2672 68101
SGTC_2474 5321570 43.32 µM -0.11508385095363 0.45204106964822 no 1860 0.454189329961369 2751 2841384
SGTC_2033 5192550 145 µM -0.115933840966766 0.451726054043777 no 1861 0.45385248765389 2635 182073
SGTC_1414 3917-0015 5.4 µM -0.117332296386248 0.451207837384554 no 1862 0.45329836648191 2617 6618702
SGTC_753 1322-0200 289 µM -0.118219197214424 0.450879227261409 no 1863 0.452946989720762 2746 5403907
SGTC_3130 9127414 49.47 µM -0.118381862091364 0.450818961119821 no 1864 0.452882548334356 2591 1494646
SGTC_1178 0988-0033 191 µM -0.118690227478363 0.450704717123005 no 1865 0.452760389579612 2741 5392207
SGTC_2851 9015922 71.43 µM -0.119008395525579 0.450586845692412 no 1866 0.452634352193669 2729 2996893
SGTC_537 1334-0398 209 µM -0.119462046584912 0.450418789531273 no 1867 0.452454653549261 2606 5846986
SGTC_2288 7946289 167.31 µM -0.121258872183841 0.449753238650547 no 1868 0.45174299740951 2715 1246052
SGTC_1418 3966-3099 2.4 µM -0.121634039484614 0.449614293058862 no 1869 0.45159442701217 2640 740335
SGTC_1743 st037606 46.3785 µM -0.123178654600017 0.449042300300536 no 1870 0.450982813997199 2662 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_87 0100-0052 35.5 µM -0.124741046839413 0.448463832148157 no 1871 0.450364280247847 2647 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_107 0358-0022 2.6945 µM -0.125068731184793 0.448342522465183 no 1872 0.450234568893569 2711 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3 0833-0587 95.581 µM -0.12519243840303 0.448296726954109 no 1873 0.450185601714195 2610 5382644
SGTC_2712 st079126 47.7 µM -0.126245574137906 0.447906891737888 no 1874 0.449768768492474 2614 3152970
SGTC_2111 5486399 200 µM -0.126802181561544 0.447700874799446 no 1875 0.449548484520714 2613 689674
SGTC_253 dyclonine 31.25 µM -0.12785711907256 0.447310449847947 no 1876 0.449131023233756 2618 3180 An oral anasthetic.
SGTC_1363 1636-0063 10.4 µM -0.128974202748275 0.446897080696379 no 1877 0.448689030769802 2639 6072185
SGTC_1012 4112-3522 18 µM -0.129449363309898 0.446721268251398 no 1878 0.448501044977617 2635 3112398
SGTC_1396 3511-0007 98.6 µM -0.133767146653362 0.445124144933378 no 1879 0.446793353419139 2744 X1396
SGTC_1432 4049-0298 68.4 µM -0.133891839769528 0.445078034767073 no 1880 0.446744051552286 2720 741646
SGTC_8 0354-0001 70 µM -0.134082368079114 0.445007580893329 no 1881 0.446668720985672 2641 4993152
SGTC_2861 9024595 19.48 µM -0.135526308391258 0.444473694877621 no 1882 0.446097882526947 2636 16482810
SGTC_1060 3448-7350 82 µM -0.135891776461565 0.444338581756767 no 1883 0.44595341830099 2727 570178
SGTC_1525 8-methoxypsoralen 92.5 µM -0.136374037590806 0.444160300279257 no 1884 0.445762798456375 2762 4114 Related to psoralen; DNA damaging agent.
SGTC_1303 1160-0052 261 µM -0.136728011498574 0.444029450992374 no 1885 0.445622893742729 2656 3562476
SGTC_320 4092-0846 5.34 µM -0.137027943679055 0.44391858343665 no 1886 0.445504353790095 2748 1359356
SGTC_814 3342-0569 96 µM -0.137192523879516 0.443857749532973 no 1887 0.445439310057698 2647 4346283
SGTC_602 3130-1533 38.1 µM -0.13866576593135 0.443313253050676 no 1888 0.444857135760691 2755 720941
SGTC_269 exalamide 29 µM -0.139245121588362 0.443099157879785 no 1889 0.444628226955139 2687 3316 A derivative of salicylamide.
SGTC_3056 9094900 49.47 µM -0.140374201907169 0.442681965168178 no 1890 0.444182169954881 2705 25236784
SGTC_892 0929-0076 29 µM -0.140403757932041 0.442671045133066 no 1891 0.44417049443252 2666 5751038
SGTC_788 1182-0090 188 µM -0.140449710233941 0.442654067268288 no 1892 0.444152341981824 2863 5715185
SGTC_2172 5754775 163.918 µM -0.140538979620829 0.442621085465776 no 1893 0.444117078400068 2672 2263357
SGTC_627 1391-0720 175 µM -0.143715967598171 0.441447564164659 no 1894 0.442862380889167 2748 997839
SGTC_1500 4488-1866 171 µM -0.143958909431587 0.441357846909788 no 1895 0.442766458549138 2805 2900003
SGTC_2381 9035592 200 µM -0.14430951264039 0.4412283761308 no 1896 0.442628033467683 2704 4749657
SGTC_1565 sinapyl alcohol 95.1 µM -0.144560532557206 0.441135683334534 no 1897 0.442528930140755 2730 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1258 0671-0043 57.1 µM -0.145286896481088 0.440867480954861 no 1898 0.442242180023318 2725 4298767
SGTC_2684 capsaicin 100 µM -0.145493105590247 0.440791345307491 no 1899 0.442160779387355 2753 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1234 0326-0494 15.5 µM -0.145556485384518 0.44076794492987 no 1900 0.442135760830045 2783 1547813
SGTC_1490 4089-0339 670 nM -0.147162206401626 0.440175167818485 no 1901 0.441501995338327 2680 742542
SGTC_2081 5214970 32.255 µM -0.148113253843898 0.439824136862973 no 1902 0.44112669487966 2694 2063512
SGTC_2580 diallyl disulphide 81.36 µM -0.148328939792944 0.439744533898132 no 1903 0.441041588659249 2706 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_539 4859-0462 2.54 µM -0.148887863970521 0.439538263738766 no 1904 0.440821058811411 2844 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_3090 9117696 49.47 µM -0.149112016248281 0.439455545272908 no 1905 0.440732622149958 2776 7923821
SGTC_2356 9061756 188.97 µM -0.149262898894011 0.439399866840837 no 1906 0.4406730948297 2725 20104043
SGTC_2831 7999036 19.48 µM -0.149734985295591 0.439225666147098 no 1907 0.440486852529741 2948 2988270
SGTC_1214 0358-0031 63.7 µM -0.15339053238326 0.437877163913595 no 1908 0.439045155299225 2974 4301366
SGTC_309 k408-0051 1.48 µM -0.155613207692324 0.437057588199828 no 1909 0.43816895677119 2708 3640463
SGTC_1381 2324-0066 62.1 µM -0.155849649015292 0.436970420101096 no 1910 0.438075767239269 2796 10885928
SGTC_2470 5664817 21.68 µM -0.158275344368857 0.436076323887435 no 1911 0.437119917791009 2678 2859561
SGTC_473 2-arachidonoylglycerol 10 µM -0.159088359374144 0.435776724458786 no 1912 0.436799629646905 2653 5282280 An endocannabinoid.
SGTC_1253 0550-0034 176 µM -0.160295294842161 0.435332031704631 no 1913 0.436324232562148 2791 5969915
SGTC_2010 4012422 159 µM -0.16192928463045 0.434730122100932 no 1914 0.435680770674024 2769 952393
SGTC_798 1287-0182 476 µM -0.163018588811411 0.434328941197329 no 1915 0.435251899348303 2719 1649755
SGTC_153 4077-0274 519.67 µM -0.165166524932599 0.433538074211037 no 1916 0.434406456295685 2842 3121976
SGTC_2603 homopterocarpin 100 µM -0.166641382192064 0.432995187747333 no 1917 0.433826115326565 2816 101795 A weak amylase inhibitor.
SGTC_207 4185-0010 4.486 µM -0.167061016804032 0.432840745723028 no 1918 0.433661019485633 2729 3761753
SGTC_1698 5-fluorocytosine 1.055 µM -0.167276259167796 0.432761532055277 no 1919 0.43357634168657 2741 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1006 4099-6547 255 µM -0.168264435596322 0.432397897297116 no 1920 0.433187625594891 2799 3146833
SGTC_781 4335-2806 94.4 µM -0.168424071121547 0.4323391590761 no 1921 0.433124836285816 2881 845254
SGTC_2050 5263056 171 µM -0.169321992781264 0.432008794846119 no 1922 0.432771689000217 2825 763468 YGL055W OLE1
SGTC_1411 3909-8223 150 µM -0.170430747380476 0.431600926367691 no 1923 0.432335696471071 2765 X1411
SGTC_1826 st055655 41.6 µM -0.171938100490478 0.431046545737237 no 1924 0.431743096369946 2759 676168
SGTC_2938 9059746 27.26 µM -0.172412998622325 0.430871913802676 no 1925 0.431556426889361 2831 6471769
SGTC_2652 actinonin 100 µM -0.172793254403732 0.430732093972105 no 1926 0.431406969747299 2684 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2003 4023581 200 µM -0.174013161353266 0.430283593584962 no 1927 0.430927559386229 2833 16641307
SGTC_187 1488-2104 32.728 µM -0.174187565063483 0.430219481166409 no 1928 0.430859028894376 2788 2852859
SGTC_1550 gossypolone 36.6 µM -0.175476778198065 0.429745611652903 no 1929 0.430352507990737 2711 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2279 7948423 32.93 µM -0.175577831158761 0.429708472398284 no 1930 0.430312809971556 2756 1247112
SGTC_2426 5582046 32.21 µM -0.176306227348233 0.429440788701943 no 1931 0.430026684975921 2865 2251934
SGTC_1330 1469-0054 61.8 µM -0.177994405159778 0.428820512687695 no 1932 0.429363684808504 2882 7102664
SGTC_1242 0402-0103 60.1 µM -0.17807919827262 0.428789362337641 no 1933 0.429330389142511 2713 432868
SGTC_2444 5485484 36.41 µM -0.178185596720395 0.428750275487633 no 1934 0.429288610432536 2842 6790631
SGTC_2983 9022671 12.99 µM -0.180039810924928 0.428069218377216 no 1935 0.428560657113688 2938 6405161
SGTC_184 1494-0393 24.714 µM -0.180705558687036 0.427824739863424 no 1936 0.428299347710137 2709 3090647
SGTC_2569 tetrandrine 100 µM -0.18092895525802 0.427742709499061 no 1937 0.428211670451088 2787 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2355 9061122 103.12 µM -0.181018190595078 0.427709943498158 no 1938 0.428176648926317 2854 5302957
SGTC_887 0885-0007 9.62 µM -0.181300907611322 0.427606136951663 no 1939 0.4280656968318 2867 5719458
SGTC_3052 9092717 49.47 µM -0.182425644889116 0.427193211529444 no 1940 0.427624350876641 2896 25237534
SGTC_2536 dehydroabietamide 32.04 µM -0.184315004854456 0.426499749493685 no 1941 0.426883171705069 2880 3983547
SGTC_1820 st053765 18.6 µM -0.185571573388273 0.426038669971404 no 1942 0.426390373735468 2797 3690829
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.185908587907313 0.425915024568419 no 1943 0.426258223716302 2877 5377381
SGTC_2009 4012297 12.05 µM -0.187113296519094 0.425473095288245 no 1944 0.425785901580747 2862 45595307
SGTC_923 1900-2434 73.3 µM -0.187296059879682 0.425406059455929 no 1945 0.425714256042976 2721 5910570
SGTC_2325 6158266 200 µM -0.187528465117973 0.425320818577888 no 1946 0.425623153806717 2816 3623240
SGTC_2928 9011484 9.79 µM -0.18755942503752 0.425309463457279 no 1947 0.425611017900053 2851 2994751
SGTC_2130 NSC 7 2.4545 µM -0.18817449289756 0.425083888847388 no 1948 0.425369933505345 2853 21448
SGTC_982 1491-0518 27.5 µM -0.188485876044981 0.424969699197945 no 1949 0.425247893186449 2768 3091256
SGTC_878 0828-0289 13.7 µM -0.188765694781122 0.424867090140504 no 1950 0.425138230009244 2762 745350 YLR208W SEC13
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.191387011371422 0.423906105898167 no 1951 0.424111197702576 2761 6708514
SGTC_1136 pergolide 1.05886 µM -0.191449689870135 0.423883133245922 no 1952 0.424086646534324 2758 47811 A dopamine receptor agonist.
SGTC_3076 9116187 49.47 µM -0.19178093720031 0.423761730204789 no 1953 0.423956901848311 2861 27241210
SGTC_3244 9134489 49.47 µM -0.191832276175845 0.423742914978945 no 1954 0.423936793867326 2817 16584271
SGTC_1910 st062352 60.4 µM -0.19244902213005 0.423516897298856 no 1955 0.423695247939455 2711 2245730
SGTC_1286 0929-0070 131 µM -0.193221424744653 0.42323387192578 no 1956 0.423392780187479 2863 1420408
SGTC_3041 9091929 49.47 µM -0.194112076244099 0.422907566727513 no 1957 0.423044062998602 2887 25236887
SGTC_554 4483-2211 187 µM -0.194140281768515 0.422897234020656 no 1958 0.423033020660091 2864 747107
SGTC_2809 7964133 12.99 µM -0.194351025103479 0.422820032770739 no 1959 0.422950517487427 2804 1253665
SGTC_633 0437-0093 97.7 µM -0.194737349490146 0.422678518909819 no 1960 0.422799285479055 2736 2831118
SGTC_1987 st072290 61.9 µM -0.195303523631265 0.42247114260885 no 1961 0.42257766936495 2807 54697379
SGTC_1806 st050005 60.3 µM -0.195332805065703 0.422460418090489 no 1962 0.422566208472856 2747 5194765
SGTC_46 0329-0187a 2.197 µM -0.196828934018557 0.421912527673531 no 1963 0.42198070396822 2842 46494817
SGTC_1972 st070201 17.4 µM -0.197011085424628 0.421845833152493 no 1964 0.421909431439404 2879 2829099
SGTC_593 1203-0218 61.7 µM -0.19737929022992 0.421711022247374 no 1965 0.421765367415704 2885 3666956
SGTC_1345 1488-0192 31.4 µM -0.197923519307722 0.421511780343816 no 1966 0.42155245121313 2834 658348
SGTC_3140 9094243 49.47 µM -0.199280173621348 0.421015197683207 no 1967 0.421021793645739 2708 19291112
SGTC_1941 st076221 61.8 µM -0.200760924301582 0.420473334854979 no 1968 0.420442759341256 2929 2828568
SGTC_486 niguldipine 82 µM -0.201367585577405 0.420251377938554 no 1969 0.420205579508801 2737 1236 A calcium channel blocker.
SGTC_2375 9072683 200 µM -0.201448433930133 0.42022180016423 no 1970 0.420173973284121 2827 16798029
SGTC_3183 9108214 49.47 µM -0.201577829603586 0.420174462647815 no 1971 0.420123389419672 2793 4974831
SGTC_2811 7967822 32.47 µM -0.202052977166447 0.42000064676474 no 1972 0.419937654193621 2899 2232244
SGTC_1119 parthenolide 318.541 nM -0.202954914667659 0.419670747866506 no 1973 0.419585135822068 2964 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_358 0075-0058 9.45 µM -0.206357066099916 0.418426863327443 no 1974 0.418256002658255 2682 1069125
SGTC_2136 5328288 199.296 µM -0.207808071570418 0.417896598285375 no 1975 0.417689414996791 2811 262395
SGTC_2959 9079155 11 µM -0.207837393204227 0.417885884328513 no 1976 0.417677967261473 2948 16189457
SGTC_2737 bleomycin 30.5 nM -0.208104083083542 0.417788440174716 no 1977 0.417573849557032 2786 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_252 miconazole 1.30953 nM -0.208232317812825 0.417741587082373 no 1978 0.41752378782556 2857 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_404 fumagillin 50 µM -0.209934953705061 0.417119606337454 no 1979 0.416859220479174 2820 12015870 A methionine aminopeptidase binder.
SGTC_2808 7946468 45.46 µM -0.210633768138568 0.416864386132527 no 1980 0.416586530123306 2858 2970879
SGTC_700 3453-2283 142 µM -0.21091953508469 0.416760028743154 no 1981 0.416475030114482 2963 565664
SGTC_47 0149-0135 24.25 µM -0.212744469034507 0.41609373151321 no 1982 0.415763139684433 2752 5239155
SGTC_2438 5259590 200 µM -0.213094000067121 0.41596614253232 no 1983 0.415626822213442 2909 1201127
SGTC_1732 st034308 51.822 µM -0.214725961755977 0.415370546527013 no 1984 0.414990490059768 2723 830119
SGTC_2349 9023730 187.07 µM -0.215002061185771 0.415269801269525 no 1985 0.414882855773157 2922 4126287
SGTC_1814 st052110 31.539 µM -0.216319088902586 0.414789310963258 no 1986 0.414369515255022 2900 674163
SGTC_2734 clemastine 41.6 µM -0.217814895661382 0.414243751433721 no 1987 0.41378666907076 2768 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2732 terfenadine 20 µM -0.219347104095833 0.413685086780131 no 1988 0.413189835712961 2781 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1619 st003326 88.7 µM -0.219964122805023 0.413460162385363 no 1989 0.412949548121498 2952 2849032
SGTC_648 0375-0473 33.3 µM -0.220484415831559 0.413270519869996 no 1990 0.412746954064625 2815 1713139
SGTC_2820 7989630 71.43 µM -0.221878500026744 0.41276248753785 no 1991 0.412204233942126 2850 2984098
SGTC_1320 1313-0481 95.3 µM -0.222960646101694 0.412368232400219 no 1992 0.41178306769499 2952 6813365 YLR208W SEC13
SGTC_859 0439-0102 54.6 µM -0.223744725046129 0.412082626407087 no 1993 0.411477971249576 2840 610143
SGTC_733 4069-0007 56.1 µM -0.224556194711509 0.411787092189431 no 1994 0.411162273037641 2814 5717425 YNL287W SEC21
SGTC_248 streptozotocin 5.23457 mM -0.225588501394959 0.411411202283137 no 1995 0.410760742447754 2883 5300 DNA alkylating agent.
SGTC_24 0417-1663 219 µM -0.225853479200724 0.411314730021817 no 1996 0.410657690567631 2878 4329390
SGTC_1979 st071809 45.3 µM -0.226104625439438 0.411223298462259 no 1997 0.410560023581424 2955 4976333
SGTC_2016 5121758 140 µM -0.227014522876953 0.410892084298282 no 1998 0.410206224671426 2750 2795203
SGTC_1905 st060207 84.5 µM -0.227465343662952 0.410728003354144 no 1999 0.410030957350708 2767 1948547
SGTC_3035 9091303 49.47 µM -0.227545605007874 0.410698793034781 no 2000 0.409999755724426 2802 25237002
SGTC_886 0866-0150 153 µM -0.228686082451864 0.410283781189607 no 2001 0.409556456381033 2999 271463
SGTC_3069 9117009 49.47 µM -0.231110306052141 0.409401957253948 no 2002 0.408614554383777 2857 41904981
SGTC_182 3448-4371 550.524 µM -0.232551310057326 0.408878001392942 no 2003 0.408054919824166 2791 3491403
SGTC_997 3996-0078 137 µM -0.23326089607362 0.408620052326904 no 2004 0.407779410755583 2885 735687
SGTC_2002 4023503 131 µM -0.233489266428242 0.408537043434442 no 2005 0.407690751700283 2883 4736863 YCR052W RSC6
SGTC_531 3788-1495 174 µM -0.234313860715785 0.408237351066932 no 2006 0.407370663058824 2778 2896655
SGTC_2309 7664088 163.95 µM -0.234610613974474 0.408129511530756 no 2007 0.407255485352546 2966 704922
SGTC_2055 5235184 200 µM -0.23466292339393 0.408110503114299 no 2008 0.40723518352885 2985 2836034
SGTC_967 1306-0166 352 µM -0.235074607082364 0.407960911318813 no 2009 0.407075413557831 2964 4437607
SGTC_3292 9120825 59.784 µM -0.235115565933565 0.407946029004231 no 2010 0.40705951871748 2934 24824900
SGTC_2483 5729050 27.16 µM -0.235810372355348 0.407693592768329 no 2011 0.406789909566885 2966 2865180
SGTC_255 tunicamycin 200.472 nM -0.236216375399484 0.407546101960664 no 2012 0.40663238664847 2909 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1420 4'-methoxyflavone 42 µM -0.236336385689521 0.40750250771558 no 2013 0.406585827398628 2877 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2519 cryptotanshinone 88.04 µM -0.236777064455371 0.407342439121145 no 2014 0.406414872784815 2970 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1510 1123-0200 71.5 µM -0.237321162923819 0.407144826535699 no 2015 0.406203822683421 3020 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2205 7238770 200 µM -0.237902259646008 0.40693380255469 no 2016 0.405978451440911 2962 279867
SGTC_1190 1486-1332 13 µM -0.238219316473937 0.406818675461051 no 2017 0.405855497967463 2822 4150046
SGTC_1302 1159-0335 255 µM -0.239178939562547 0.406470274045177 no 2018 0.405483416293034 2823 649284
SGTC_858 0438-0351 2.77 µM -0.239307386885746 0.406423645483749 no 2019 0.405433618946276 2861 2799119
SGTC_1479 0549-0158 134 µM -0.239454882924048 0.406370103551732 no 2020 0.405376438549924 2871 5440202
SGTC_1142 3253-1408 9.78 µM -0.240240964691727 0.406084780783842 no 2021 0.405071729085672 2808 256655
SGTC_1864 st057645 30.4 µM -0.241370425951519 0.405674909486392 no 2022 0.404634015946661 2854 688666
SGTC_2650 prasterone 100 µM -0.242904768850665 0.405118276002973 no 2023 0.404039585594247 2839 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_943 3253-1379 105 µM -0.243964781000504 0.404733833646745 no 2024 0.403629048278844 3008 668464
SGTC_2247 cerulenin 830 nM -0.244571317234865 0.404513898047177 no 2025 0.403394187599976 3054 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_669 0108-0021 26.2 µM -0.244608198331196 0.404500525595802 no 2026 0.403379907763335 2890 17201
SGTC_3315 9136395 68.55 µM -0.244699649260137 0.404467367542724 no 2027 0.403344499818407 2912 16876844
SGTC_2696 st077691 74.316 µM -0.245764756521107 0.4040812341613 no 2028 0.402932170315807 2977 757133
SGTC_1644 st010134 20.9 µM -0.246101920199835 0.403959021650869 no 2029 0.402801668340268 2889 3818134
SGTC_279 1273-0055 2.93 µM -0.246492539117262 0.403817444816521 no 2030 0.402650489615122 2905 2847562
SGTC_1785 bathophenanthroline 24 µM -0.247911913857297 0.403303109519745 no 2031 0.402101280842459 2861 72812 An iron chelator.
SGTC_335 4077-0256 27.6 µM -0.24791246098761 0.403302911289679 no 2032 0.40210106917462 2932 3121989
SGTC_373 0844-0104 25.9 µM -0.25114167864859 0.402133372187315 no 2033 0.400852286673277 2980 5375804
SGTC_23 0213-0011 39.996 µM -0.25135172062874 0.402057330634413 no 2034 0.400771095508812 3022 627608
SGTC_2767 sibutramine 71.45 µM -0.252445742445774 0.401661321631719 no 2035 0.400348273689297 3037 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3201 9113999 49.47 µM -0.252543911904013 0.401625791631525 no 2036 0.400310338475729 3048 16649224
SGTC_649 1123-0311 367 µM -0.252795755706119 0.401534646734334 no 2037 0.400213023829508 2957 693629 YIL048W NEO1
SGTC_806 3966-4455 5.86 µM -0.253218377944732 0.401381707379946 no 2038 0.400049732827248 2856 714982
SGTC_3262 9137218 49.47 µM -0.253251731970226 0.401369637803476 no 2039 0.400036846382814 2782 17650664
SGTC_3133 9127736 49.47 µM -0.253374529043998 0.401325202938509 no 2040 0.399989404241956 2914 27243420
SGTC_2594 a-mangostin 100 µM -0.254354606810041 0.400970601645029 no 2041 0.399610808216185 3029 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2259 7964009 200 µM -0.254874640110019 0.400782481842932 no 2042 0.399409961903725 3004 313134
SGTC_2168 5727979 200 µM -0.255220876392376 0.400657245117466 no 2043 0.399276253916584 2800 695210
SGTC_1463 k081-0032 34.1 µM -0.255560068000275 0.40053456641425 no 2044 0.39914527786706 2932 977755
SGTC_2100 5377183 190 µM -0.256115385705733 0.400333740484141 no 2045 0.398930871017604 2950 2844202
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.25685053207116 0.400067921583387 no 2046 0.398647079661182 2872 5106787 A p450 inhibitor.
SGTC_3327 9140648 26.9345 µM -0.257741838245083 0.399745699524813 no 2047 0.398303077214284 3000 8029710
SGTC_221 trifluoperazine 10.304 µM -0.258676681672405 0.399407811368149 no 2048 0.39794235633211 2884 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_889 0919-1524 82.7 µM -0.259048744697992 0.399273354509348 no 2049 0.397798815466444 2929 3905452
SGTC_875 0709-0210 25.7 µM -0.259746581081937 0.399021201273551 no 2050 0.397529629479373 2894 6251364
SGTC_3318 9139014 38.6185 µM -0.260091302046955 0.398896656804093 no 2051 0.397396673535162 2840 16643984
SGTC_898 1000-0849 28.3 µM -0.261153049010172 0.398513122255652 no 2052 0.396987241723702 2947 6751807
SGTC_2681 menadione 3.18 µM -0.262018178281904 0.398200684300192 no 2053 0.396653713708989 2949 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_519 k048-0011 62.8 µM -0.262488484173682 0.398030862587007 no 2054 0.396472431248524 2991 6836379
SGTC_1597 7-benzyloxygramine 47.5 µM -0.263259929307682 0.397752345012317 no 2055 0.396175121186922 2862 260807
SGTC_805 3852-0218 479 µM -0.263702702965037 0.397592512394048 no 2056 0.396004506287747 2853 6615355
SGTC_1920 st075728 45.7 µM -0.263902799902578 0.397520286956774 no 2057 0.395927409049753 3077 3400306
SGTC_1055 3448-0672 86 µM -0.265352081596007 0.396997270504689 no 2058 0.395369123330482 3015 748378
SGTC_1168 k815-0004 80.5 µM -0.265504400542464 0.396942312416661 no 2059 0.395310460163863 2862 642433
SGTC_1376 2910-0861 41.3 µM -0.267259445753136 0.396309223746588 no 2060 0.394634704491222 2854 1112859
SGTC_3223 9129970 49.47 µM -0.267763988307111 0.396127273147069 no 2061 0.394440495979878 2852 17248386
SGTC_3308 9128332 17.569 µM -0.268304807065019 0.395932265570755 no 2062 0.394232353166699 3035 17332805 YDL196W YDL196W
SGTC_1752 st044819 83.042 µM -0.268654204017786 0.39580629441183 no 2063 0.394097898174042 2901 441209 YML126C ERG13
SGTC_4 0960-0234 25.671 µM -0.269899064374272 0.395357562492345 no 2064 0.393618953497369 2955 6821112
SGTC_2277 7947813 106.88 µM -0.270638685196312 0.395091018744321 no 2065 0.3933344696531 3112 1246798
SGTC_1141 3253-0389 52.6 µM -0.270862145612747 0.395010497971561 no 2066 0.393248530213126 2983 5402031
SGTC_3012 9080433 71.4286 µM -0.271380501903797 0.394823732946471 no 2067 0.393049198388457 2990 17688859
SGTC_3288 9119690 36.221 µM -0.271923072554965 0.394628269315721 no 2068 0.392840585063578 2929 17595618 YKL019W RAM2
SGTC_469 w7 172 µM -0.274095326997346 0.393845970569652 no 2069 0.392005682444632 2901 45115570 A P450 inhibitor.
SGTC_1526 st051518 75 µM -0.275087523533545 0.393488790922576 no 2070 0.391624498363019 2940 673993
SGTC_939 1165-0479 45.3 µM -0.277720427106362 0.392541410267014 no 2071 0.390613489326168 3026 1377347
SGTC_1708 st033234 31.827 µM -0.281116077980505 0.391320515492591 no 2072 0.389310684886655 3030 674664
SGTC_1157 4092-0394 27.6 µM -0.281487347006288 0.391187091646452 no 2073 0.38916831577378 3082 3659885
SGTC_2348 9022543 33.42 µM -0.281984635790226 0.391008399839046 no 2074 0.3889776456595 3042 3162678 YDL140C RPO21
SGTC_2646 retinol 96.75 µM -0.282498588236091 0.390823744420499 no 2075 0.388780614470443 2975 445354 A vitamin A analog and teratogen.
SGTC_1269 0831-0796 3.05 µM -0.282641313707671 0.390772469660697 no 2076 0.388725903645667 3039 927758
SGTC_765 1319-0117 244 µM -0.286457869683961 0.389402062013177 no 2077 0.387263728558216 2895 3487746 YGL099W LSG1
SGTC_869 0564-0080 44.1 µM -0.286713995117476 0.389310144282824 no 2078 0.387165660371935 2955 6843321
SGTC_127 0180-0333 59.125 µM -0.287954080842927 0.388865192724781 no 2079 0.386690944351775 2919 771601
SGTC_1102 cgs 12066b 26.1 µM -0.288842707524064 0.388546436764235 no 2080 0.386350874230348 2954 6438352 A 5-HT1B full agonist.
SGTC_1387 3342-1166 1.8 µM -0.290617897508648 0.387909889860829 no 2081 0.385671785190903 2979 3418228
SGTC_1647 st011722 22.4 µM -0.29076651454081 0.387856612460627 no 2082 0.385614948434861 3076 2854783
SGTC_621 3584-0052 32.1 µM -0.291484519442618 0.387599246180771 no 2083 0.385340390907655 3024 2273927
SGTC_1691 st019933 84.6 µM -0.292848732782797 0.387110384936125 no 2084 0.384818888463561 3008 6176082
SGTC_1997 st073024 93.8 µM -0.293713039199667 0.386800756228409 no 2085 0.384488594864055 3057 686268
SGTC_1726 st035556 14.5795 µM -0.294547739907639 0.386501801827447 no 2086 0.384169694624796 3127 5919439
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.295572830834033 0.38613474988559 no 2087 0.383778162433675 2940 97141
SGTC_1710 st031758 61.5 µM -0.296060447943025 0.385960185694233 no 2088 0.383591959298784 3080 5394341
SGTC_811 0416-0114 265 µM -0.29670623487168 0.385729033135659 no 2089 0.38334539827447 3017 6612453
SGTC_2275 7947463 200 µM -0.297790285843386 0.38534109988358 no 2090 0.382931614579745 3075 1225414
SGTC_1834 st055981 52.8 µM -0.298758832767299 0.384994597355594 no 2091 0.382562031888884 3082 471719 YDL150W RPC53
SGTC_720 r052-1644 49.9 µM -0.299071119454061 0.384882894786324 no 2092 0.382442890847219 3054 1422863 YOR257W CDC31
SGTC_1684 st024538 14.6195 µM -0.302929448467539 0.383503590809818 no 2093 0.380971814254213 2936 6732859
SGTC_462 ag-879 158 µM -0.30326785431831 0.383382685094641 no 2094 0.380842870927075 3046 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1061 3448-9325 110 µM -0.303420589440323 0.383328119576096 no 2095 0.380784678350296 2951 723482
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.303464175737592 0.383312548540057 no 2096 0.380768072324237 2865 6708630 An antioxidant.
SGTC_2563 tomatine 8.54 µM -0.304542771012178 0.382927284658492 no 2097 0.380357206307208 3124 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1683 st010134 710 nM -0.305411317063413 0.382617132486662 no 2098 0.380026451761102 2927 3818134
SGTC_2333 9017922 200 µM -0.305919282814897 0.382435776075904 no 2099 0.379833051903598 3085 3163164
SGTC_236 1509-0011 5.31 µM -0.306424039062312 0.382255591076258 no 2100 0.379640903780597 3060 3107280
SGTC_2889 9059656 51.95 µM -0.30687857064078 0.382093356805937 no 2101 0.379467900364869 3036 3949838
SGTC_614 0462-0418 107 µM -0.308063924030378 0.381670370464219 no 2102 0.379016845782226 2985 5188303
SGTC_265 mycophenolic acid 32.932 µM -0.308099803762176 0.381657569194372 no 2103 0.379003195273209 3198 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2882 9058044 58.44 µM -0.311495326165315 0.380446692897185 no 2104 0.3777120477313 3033 18076804
SGTC_2112 5488546 200 µM -0.311532340772284 0.380433499556548 no 2105 0.377697980421521 2934 600757
SGTC_2689 tacrolimus 100 µM -0.311921659093602 0.380294740895699 no 2106 0.377550030785962 3024 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3347 9188721 44.724 µM -0.312473054632996 0.380098241938745 no 2107 0.377340518942563 3020 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_156 3474-0145 5.642 µM -0.31260705304372 0.380050494051914 no 2108 0.377289609482451 2929 2265471
SGTC_2124 5246320 200 µM -0.313113542222726 0.379870032402099 no 2109 0.377097200421119 3040 579342
SGTC_2911 7942208 15.64 µM -0.313209585950771 0.379835815055217 no 2110 0.377060718020406 3037 1243384
SGTC_740 k014-0057 261 µM -0.316489541628794 0.37866783676553 no 2111 0.375815481051128 3065 4012779
SGTC_84 0443-0269 128.823 µM -0.316567914729924 0.378639941941051 no 2112 0.375785742416808 3046 6150058
SGTC_2625 euphol 100 µM -0.316678993324304 0.378600407547739 no 2113 0.375743594963253 3113 6708538 A triterpene alcohol.
SGTC_1948 st076329 66.6 µM -0.317703259876166 0.378235916971692 no 2114 0.375355019109556 2900 24208413
SGTC_1927 st060202 13.8 µM -0.318711410139667 0.377877267244301 no 2115 0.374972680746708 2964 688887
SGTC_549 1661-1316 519 µM -0.318812929833233 0.377841157413296 no 2116 0.374934186468555 3110 2857282
SGTC_390 dec-rvkr-cmk 16.7 µM -0.319767434965097 0.377501698983006 no 2117 0.37457231780358 3019 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_660 4031-1742 102 µM -0.3204848074563 0.377246636219807 no 2118 0.374300422711765 2973 6738706
SGTC_3100 9120536 49.47 µM -0.321777358584679 0.376787203123806 no 2119 0.373810684012794 2929 16421196
SGTC_717 1532-0246 73.2 µM -0.323077620449211 0.376325205259247 no 2120 0.373318229243156 3039 9561992
SGTC_1623 st003709 20.3 µM -0.323317817100089 0.376239880014833 no 2121 0.373227280958142 2956 16192618
SGTC_2606 farnesol 9.78 µM -0.324882425152551 0.375684231260438 no 2122 0.372635029350708 3151 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2671 danthron 100 µM -0.325703351005923 0.375392793890338 no 2123 0.372324404317747 3036 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_57 miconazole 162.5 nM -0.325958817622631 0.375302115034668 no 2124 0.372227756825455 2987 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2343 7990716 14.84 µM -0.326418086420527 0.375139113143393 no 2125 0.372054027643564 2954 6456862
SGTC_960 1222-0186 7.7 µM -0.326652517200976 0.375055918477787 no 2126 0.371965358746196 3101 3126296
SGTC_9 0092-0002 10.449 µM -0.32766079547035 0.374698167551034 no 2127 0.371584074495607 3035 759368
SGTC_2528 xanthyletin 44.79 µM -0.327706405970024 0.374681986868253 no 2128 0.371566829687107 2968 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2144 5628481 200 µM -0.327858811193428 0.374627921519464 no 2129 0.371509208884224 2993 2818399
SGTC_1206 3978-0017 132 µM -0.32881943311434 0.374287200203412 no 2130 0.371146086816699 3237 3873677
SGTC_1648 st011736 69.8 µM -0.329455692772721 0.374061580395922 no 2131 0.370905639157642 3128 2855514
SGTC_496 calpeptin 138 µM -0.330175160438924 0.373806506717189 no 2132 0.370633807239897 3043 73364 A calpain inhibitor.
SGTC_1176 0848-0131 83.3 µM -0.330321792448503 0.373754527881373 no 2133 0.370578414111501 3067 6769040
SGTC_375 3970-0961 9.27 µM -0.331756393369316 0.373246104749786 no 2134 0.370036607064899 3021 2898222
SGTC_357 1325-0123 420 µM -0.33254608711379 0.372966331061406 no 2135 0.369738472654759 3115 1098503
SGTC_2920 7982904 15.77 µM -0.332747709201553 0.372894910864105 no 2136 0.369662366466549 3090 6456808
SGTC_1343 1487-0095 224 µM -0.33441054917237 0.372306053111223 no 2137 0.369034890046908 3133 4560101 YGL055W OLE1
SGTC_85 0868-0259 160.055 µM -0.334783115643624 0.372174157866142 no 2138 0.368894349026023 3040 83173
SGTC_443 clozapine 122 µM -0.335187636560313 0.372030967151098 no 2139 0.368741773869427 3058 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2098 5376439 882.5 nM -0.337027649552135 0.371379870205943 no 2140 0.368048028438385 3096 2844116
SGTC_2724 maprotiline 69.64 µM -0.337058224315346 0.371369054289456 no 2141 0.368036504373667 3122 4011 A tricyclic antidepressant.
SGTC_984 1492-0255 2.91 µM -0.337692488756972 0.371144704214404 no 2142 0.367797467851141 3104 1585198
SGTC_1145 3546-0597 10.2 µM -0.337951665586569 0.371053041576873 no 2143 0.367699806083844 3041 875334
SGTC_2418 pentamidine 31.67 µM -0.338247210932926 0.370948525474047 no 2144 0.367588450545576 3091 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2965 9082772 38.63 µM -0.341757165585526 0.369708001525066 no 2145 0.366266823765825 3199 16459634
SGTC_2982 9019404 25.97 µM -0.341966741068156 0.369633973959183 no 2146 0.366187960886389 3016 22333232
SGTC_2027 5150920 200 µM -0.34232498315025 0.36950744463534 no 2147 0.366053168120513 3061 786715
SGTC_3265 9137266 49.47 µM -0.344719475924461 0.368662085183475 no 2148 0.365152637473729 3094 17224265
SGTC_1690 st023502 41.2 µM -0.344724025662795 0.368660479532496 no 2149 0.365150927095305 3108 24207482
SGTC_1020 4335-0961 93.3 µM -0.345280409477559 0.368464143068061 no 2150 0.364941786535517 2960 669075
SGTC_1715 st032160 10.2275 µM -0.345317122785512 0.368451188899956 no 2151 0.364927987686948 3124 5289825
SGTC_2565 isoliquiritigenin 100 µM -0.345401061969114 0.368421571801086 no 2152 0.364896439455021 3139 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_383 2324-0395 7.37 µM -0.347405877738031 0.367714425349112 no 2153 0.364143209107705 3148 3146421
SGTC_2158 5657123 3.6195 µM -0.348017150640825 0.367498903834878 no 2154 0.363913651660355 3010 2858827
SGTC_1223 0764-0573 147 µM -0.348031287197408 0.367493920086272 no 2155 0.363908343394792 3018 1609797
SGTC_989 1501-0895 10.3 µM -0.350573058991428 0.366598198909793 no 2156 0.362954335544799 3138 2830112
SGTC_1219 1469-0211 33.1 µM -0.351442884260619 0.366291838711578 no 2157 0.362628057311889 3145 6822282
SGTC_3338 9144300 39.5675 µM -0.351727350639322 0.366191665600751 no 2158 0.362521373387389 3081 4901274
SGTC_3311 9131146 2.8755 µM -0.351766963145242 0.366177717020061 no 2159 0.362506518286358 3057 4900406 YPR165W RHO1
SGTC_299 1273-0059 1.44 µM -0.35461723910911 0.365174526824048 no 2160 0.361438179763385 3123 2848077
SGTC_2824 7998404 51.95 µM -0.35607452704889 0.364661971889776 no 2161 0.360892376573354 3006 837851
SGTC_3237 9133362 49.47 µM -0.356167539524524 0.36462926589422 no 2162 0.360857549884913 3129 43845137
SGTC_1560 lithocholic acid 53.1 µM -0.35632221763677 0.3645748785802 no 2163 0.36079963626888 3104 9903 A bile acid which acts as a detergent.
SGTC_306 1672-3436 11.6 µM -0.356412130391749 0.364543265060983 no 2164 0.360765973161669 3135 6797378
SGTC_1325 1431-0015 227 µM -0.357734613318491 0.364078383732128 no 2165 0.360270963658561 3034 1103340
SGTC_2228 7354201 200 µM -0.358124268399676 0.363941449653633 no 2166 0.360125159162023 3055 753451
SGTC_330 1488-0319 80.1 µM -0.358173759510025 0.36392405854144 no 2167 0.36010664160754 3102 6846614
SGTC_2152 5568786 200 µM -0.359283745029516 0.363534084763138 no 2168 0.359691416620019 3067 5399883
SGTC_525 k781-2675 26.7 µM -0.359742789050102 0.363372849063041 no 2169 0.359519745135727 3098 3651118 YDL195W SEC31
SGTC_1212 0520-0165 585 µM -0.360068435006462 0.363258483085405 no 2170 0.359397978522539 3426 5403258
SGTC_1940 st075990 51.1 µM -0.360074971580363 0.363256187583119 no 2171 0.35939553449133 3291 1084979
SGTC_526 4469-0568 170 µM -0.363480235780925 0.362061002510595 no 2172 0.358123087186116 3037 2901964
SGTC_1372 2752-0194 270 µM -0.363970610989546 0.361889000253685 no 2173 0.35793997771144 3038 823334
SGTC_1540 guanosine 70.6 µM -0.364692690548694 0.361635776991212 no 2174 0.357670407738196 3067 6802 Guanosine is a purine nucleoside
SGTC_1807 st050092 58.9 µM -0.366828951956631 0.360886974934155 no 2175 0.356873305150763 3047 5008496
SGTC_1573 oleylamine 1.06 µM -0.367943535867425 0.360496502501536 no 2176 0.356457668461323 3037 5356789 An amine of the fatty acid oleic acid.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.368392463452948 0.360339270660848 no 2177 0.356290308120586 3139 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1523 st012844 44.7 µM -0.368439813804339 0.360322688108894 no 2178 0.356272657508148 3181 4274103
SGTC_663 1486-0733 13.9 µM -0.369795961897534 0.359847863543887 no 2179 0.355767262120461 3051 722445 YPR165W RHO1
SGTC_1650 st011916 45.8 µM -0.369961919780456 0.359789771980973 no 2180 0.355705432021185 3196 242528
SGTC_964 1287-0107 19.4 µM -0.371696701298867 0.359182726668349 no 2181 0.355059340654466 3216 51516812 YPR165W RHO1
SGTC_1375 2910-0797 186 µM -0.371799144799981 0.359146890111314 no 2182 0.355021200233205 3101 742508
SGTC_1265 0819-1001 68.8 µM -0.373772368663515 0.358456863514064 no 2183 0.354286839272357 3123 3106768
SGTC_2044 5102272 200 µM -0.374667969070326 0.358143828751034 no 2184 0.353953708404409 3160 592666
SGTC_2276 7947513 42.08 µM -0.375040654732088 0.358013593860499 no 2185 0.353815115773301 3136 2105100
SGTC_1702 st027038 51 µM -0.377024775621877 0.357320521875807 no 2186 0.353077596483999 3116 5521182
SGTC_3279 9140807 49.47 µM -0.377298026534016 0.357225109578507 no 2187 0.352976069301747 3100 45595718
SGTC_2332 7982454 138.89 µM -0.378146158989326 0.356929020082754 no 2188 0.352661009876594 3163 2981748
SGTC_1450 4112-4260 37.6 µM -0.380080663474855 0.356253992475123 no 2189 0.35194276947309 3214 1633175
SGTC_3018 9082602 49.47 µM -0.381097565801025 0.355899334115296 no 2190 0.351565426791936 3148 17332089
SGTC_1751 st044839 27.194 µM -0.382437832844111 0.355432088437014 no 2191 0.351068316322597 3134 5291326
SGTC_560 2332-1943 155 µM -0.383736771415209 0.354979457984696 no 2192 0.35058677781973 3090 21177716
SGTC_750 4073-0104 132 µM -0.383816087308876 0.354951826048341 no 2193 0.350557381842802 3117 22330957
SGTC_2254 7938975 95.19 µM -0.384880803008872 0.354580976110863 no 2194 0.35016286467507 3244 2969277
SGTC_1250 0485-0349 40.2 µM -0.385561160271332 0.354344073768288 no 2195 0.349910851367434 3096 6842794 YDL195W SEC31
SGTC_80 0159-0065 512.242 µM -0.386156797240557 0.354136717529578 no 2196 0.349690273836364 3169 1548079
SGTC_2989 9073649 71.4286 µM -0.386916429163743 0.353872333262558 no 2197 0.349409038961437 3185 21367202
SGTC_2721 ifenprodil 61.44 µM -0.387313909403852 0.353734021275305 no 2198 0.34926191469104 3221 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2709 st078560 56 µM -0.387929237030628 0.35351994258109 no 2199 0.349034200552542 3257 17250903
SGTC_3028 9087778 49.47 µM -0.388339446712701 0.353377252222256 no 2200 0.348882424548575 3088 17217395
SGTC_115 0527-0192 112.043 µM -0.388618946152826 0.353280040879265 no 2201 0.348779024677992 3181 4233931
SGTC_553 k007-0256 45.7 µM -0.389358352057112 0.353022917873155 no 2202 0.348505538141315 3134 6287000
SGTC_507 nimesulide 162 µM -0.389638583018833 0.352925487128921 no 2203 0.348401908742454 3280 4495 A COX2 inhibitor.
SGTC_112 phenothiazine 287.218 µM -0.390029544587751 0.352789573662665 no 2204 0.348257350074944 3233 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1341 1486-1360 280 µM -0.39044010774048 0.352646866144156 no 2205 0.34810556741762 3082 3976547
SGTC_6 0844-0013 19.835 µM -0.3921335910508 0.352058448148783 no 2206 0.347479754493355 3191 1584900
SGTC_3084 9116877 49.47 µM -0.392619771669744 0.351889585102158 no 2207 0.347300167105981 3162 27241325
SGTC_2163 5671233 125 µM -0.393293128671025 0.351655759126643 no 2208 0.347051496359918 3305 701023
SGTC_1156 4092-0367 4.88 µM -0.39428575870658 0.351311166626821 no 2209 0.346685038186187 3135 1357585
SGTC_2448 5185112 27.17 µM -0.394472515782184 0.351246347372041 no 2210 0.346616107412228 3218 5718189
SGTC_2240 6690706 185.951 µM -0.395450404473289 0.350907014493628 no 2211 0.346255258261329 2989 805876
SGTC_1795 st049545 62.3 µM -0.398806262110956 0.349743418432105 no 2212 0.345017981279557 3206 5291882
SGTC_2218 6965428 192.983 µM -0.399239803661778 0.349593196661997 no 2213 0.344858258543705 3195 675684
SGTC_1177 0983-0204 23.6 µM -0.399730353501745 0.349423249967717 no 2214 0.344677566497737 3249 766818
SGTC_2232 chlorophetanol 41.5365 µM -0.403106182314143 0.348254543738275 no 2215 0.34343505637779 3214 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_865 0488-0499 301 µM -0.403465861207382 0.348130108175795 no 2216 0.343302772086996 3266 9634651
SGTC_1888 azatryptophan 97.5 µM -0.40614330036818 0.347204328119401 no 2217 0.342318655943194 3198 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.407660640806596 0.346680080283444 no 2218 0.34176141866095 3030 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_366 0181-0206 4.31 µM -0.40816882940836 0.346504564423937 no 2219 0.341574865380516 3318 274874
SGTC_487 nimodipine 119 µM -0.408414894369696 0.346419591467878 no 2220 0.341484550167877 3150 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1328 1441-0025 69.2 µM -0.408580063752833 0.34636255830056 no 2221 0.341423931803939 3100 4562601
SGTC_191 3914-0123 66.505 µM -0.409748441168882 0.345959215848797 no 2222 0.340995245695969 3085 3144412
SGTC_1442 4112-3290 3 µM -0.411260810589095 0.345437381388705 no 2223 0.340440651195981 3117 704353
SGTC_328 k915-0120 63.5 µM -0.411560529446347 0.345333999934438 no 2224 0.34033078348806 3227 6624543
SGTC_288 1315-0019 35.1 µM -0.411606578438391 0.345318117365755 no 2225 0.340313904545715 3233 6811474
SGTC_1641 st009299 47.1 µM -0.41246645110444 0.34502159227563 no 2226 0.33999878290918 3221 4046054
SGTC_1127 asiatic acid 681.4 nM -0.413260916564379 0.344747707264004 no 2227 0.339707730676347 3101 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1346 1488-2224 62.4 µM -0.415212202374454 0.344075364068523 no 2228 0.338993283405617 3240 3722427
SGTC_1017 4239-0030 168 µM -0.415344300169959 0.344029865680787 no 2229 0.338944937768785 3156 1149593
SGTC_2848 9016370 25.97 µM -0.416760044305671 0.343542383430678 no 2230 0.338426965215181 3277 7894410
SGTC_1853 st056710 91.2 µM -0.419736086779015 0.342518493534394 no 2231 0.337339129838294 3287 269167
SGTC_2429 5902844 64.44 µM -0.420368177929213 0.342301174897098 no 2232 0.337108255594094 3242 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.423421861433983 0.341252027473218 no 2233 0.33599374875309 3168 364106
SGTC_3259 9138485 49.47 µM -0.425157951991784 0.340656108624158 no 2234 0.335360767085962 3438 17646153
SGTC_2556 citropten 84.59 µM -0.425617663026021 0.340498377788867 no 2235 0.335193233780204 3156 2775 A potential DNA crosslinker.
SGTC_1426 4048-4480 71.7 µM -0.425692157928651 0.340472820568504 no 2236 0.335166088556261 3260 14224343
SGTC_3330 9141424 71.43 µM -0.426894797248651 0.340060328441361 no 2237 0.334727977598349 3259 27261020
SGTC_1289 0976-0073 69.1 µM -0.427994488218011 0.339683313948478 no 2238 0.334327566627542 3255 3391136
SGTC_1085 doxorubicin 7.67 µM -0.428295088881933 0.339580284878731 no 2239 0.334218147012582 3276 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1304 1165-0502 251 µM -0.42869467764059 0.339443346793312 no 2240 0.334072717220172 3168 767425
SGTC_163 TUB2.036 7.546 µM -0.429391548912947 0.339204581448022 no 2241 0.3338191514699 3244 15992207 YJR013W GPI14
SGTC_2149 5554786 194.827 µM -0.42971152397617 0.33909497169167 no 2242 0.333702749755069 3165 745063 YPR165W RHO1
SGTC_2102 5377816 72.7585 µM -0.431512462371318 0.338478301557094 no 2243 0.333047896514024 3327 1379702
SGTC_1117 retinoic acid 1.10837 µM -0.432239951247748 0.338229320374793 no 2244 0.332783512768658 3306 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_101 0490-5701 117.494 µM -0.432464479415523 0.338152490469123 no 2245 0.332701931603656 3232 4661669
SGTC_1266 0828-0227 32.9 µM -0.43254344050543 0.338125472863603 no 2246 0.332673243376723 3217 3913820
SGTC_1604 st002052 72.4 µM -0.432731324110786 0.338061189297305 no 2247 0.332604985245623 3297 6254834 YHR062C RPP1
SGTC_1380 2291-0730 164 µM -0.433550544958669 0.337780951610316 no 2248 0.332307427112149 3223 2999191
SGTC_930 2810-3379 265 µM -0.436011014634587 0.336939819318779 no 2249 0.331414369017049 3358 1015764
SGTC_2430 5571206 200 µM -0.43652251747638 0.336765059919769 no 2250 0.331228832772091 3325 1731771
SGTC_2865 9030313 51.95 µM -0.437375593087541 0.336473677621437 no 2251 0.330919490794408 3112 42562754
SGTC_2910 7948405 25.97 µM -0.438324687995555 0.336149613693993 no 2252 0.330575465953838 3302 2971328
SGTC_1046 2001-0062 216 µM -0.438972747914182 0.335928406648521 no 2253 0.330340641492292 3174 739778
SGTC_2427 5545055 42.75 µM -0.439990394538794 0.335581160552946 no 2254 0.329972032140509 3172 5372858
SGTC_513 4245-1575 41.7 µM -0.440576074010866 0.3353813759121 no 2255 0.329759963614989 3216 719745
SGTC_2529 gangaleoidin 93.61 µM -0.44152307993693 0.335058435526287 no 2256 0.32941717827411 3148 4565183
SGTC_2436 5633522 8.09 µM -0.44154425984428 0.335051214316468 no 2257 0.329409513473939 3328 5724242
SGTC_67 0335-0847 266 µM -0.442529237699601 0.334715457208387 no 2258 0.329053138900728 3424 4552207 YOR254C SEC63
SGTC_395 anisomycin 6.25 µM -0.442868371058613 0.334599884726583 no 2259 0.32893047307835 3239 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3304 9125678 46.087 µM -0.442911811267157 0.334585081969182 no 2260 0.328914761920883 3167 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3323 9138564 53.9225 µM -0.443552126176635 0.334366917038156 no 2261 0.32868321228384 3332 43912313 YNL103W MET4
SGTC_339 3091-4833 71.4 µM -0.443785684139013 0.334287354240915 no 2262 0.328598769795147 3214 3240077
SGTC_3350 9150499 3.57 µM -0.44534868858381 0.333755099982117 no 2263 0.328033893608923 3155 4910996 YPR165W RHO1
SGTC_2486 5283202 22.39 µM -0.445413057645826 0.333733187367259 no 2264 0.328010638786658 3191 1377751
SGTC_1160 4092-0570 10.5 µM -0.446027381265321 0.333524086919022 no 2265 0.327788733633166 3193 4994975
SGTC_1421 4029-0249 71.4 µM -0.447168711235598 0.333135743958461 no 2266 0.327376625399521 3337 2894095
SGTC_94 0334-0113 514.748 µM -0.447358184968035 0.333071291917406 no 2267 0.327308231093941 3212 6795178
SGTC_689 0833-0039 98 µM -0.447463069438882 0.333035616172455 no 2268 0.327270373454335 3240 5374726
SGTC_2191 5911152 200 µM -0.449936266187701 0.332194813510922 no 2269 0.326378198375165 3243 2875902
SGTC_2801 7907800 81.82 µM -0.450616026343846 0.331963865895213 no 2270 0.326133156976136 3266 6620925
SGTC_963 1269-2853 151 µM -0.450753952769164 0.331917013360637 no 2271 0.326083446118171 3180 3668223
SGTC_3151 9099821 49.47 µM -0.451824185863974 0.33155355286477 no 2272 0.325697822324621 3289 17174189
SGTC_2708 st078559 56 µM -0.452423179744137 0.331350198495783 no 2273 0.325482075648447 3293 17250902
SGTC_3118 9124250 49.47 µM -0.453235864279678 0.331074377085875 no 2274 0.325189454967506 3202 1504786
SGTC_3191 9110352 49.47 µM -0.454452010699099 0.330661793778051 no 2275 0.32475176241716 3267 17122424
SGTC_691 1548-0686 185 µM -0.454907906215841 0.330507182084313 no 2276 0.324587747368962 3220 46495133
SGTC_983 1491-0821 12.2 µM -0.45526941219317 0.330384602070442 no 2277 0.324457714508035 3303 46495113
SGTC_1357 1503-1303 39.5 µM -0.457244131609418 0.329715332600262 no 2278 0.323747790582823 3225 292895
SGTC_3261 9137475 49.47 µM -0.458482407760322 0.329295935390659 no 2279 0.323302949313704 3213 17027690
SGTC_385 1494-0393 12.4 µM -0.459492274505163 0.328954058084506 no 2280 0.322940349273599 3223 3090647
SGTC_111 0083-0039 52.457 µM -0.460786823195755 0.328516014624705 no 2281 0.322475778170296 3169 759313
SGTC_2087 5276107 200 µM -0.462424965240661 0.327962045320484 no 2282 0.321888299842093 3206 144405
SGTC_300 r073-0011 5.04 µM -0.462816676655239 0.327829636552533 no 2283 0.321747888281142 3318 2735780
SGTC_51 1013-0126 23.419 µM -0.463134384882386 0.327722258703661 no 2284 0.321634022348218 3455 1627850
SGTC_1182 1222-0449 220 µM -0.463982559223954 0.327435665678076 no 2285 0.321330120609612 3280 658318
SGTC_2736 butenafine 14.65 µM -0.464555098183891 0.327242265661903 no 2286 0.321125046900977 3214 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1878 temozolomide 1 mM -0.464676913075043 0.327201123347848 no 2287 0.321081421915099 3317 5394 DNA alkylating agent.
SGTC_1404 3909-7820 48.3 µM -0.46498435115716 0.327097297151642 no 2288 0.320971331562771 3321 23741373
SGTC_2560 caryophyllene 100 µM -0.468151384208405 0.326028525277571 no 2289 0.31983816774874 3227 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2365 9042475 200 µM -0.468698721855948 0.325843960853757 no 2290 0.319642500339657 3313 6464479
SGTC_1921 5740136 50 µM -0.473259250355847 0.324307795160622 no 2291 0.318014115372955 3372 1774243
SGTC_39 0986-0283 58.349 µM -0.473319085912215 0.32428765997516 no 2292 0.317992773730249 3412 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2902 5787006 60.46 µM -0.474966446127639 0.323733510905586 no 2293 0.317405444745325 3177 591003
SGTC_1086 cerivastatin 2.18 µM -0.475318667726434 0.323615079095266 no 2294 0.317279927676281 3307 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1788 fluconazole 20 µM -0.475835593791277 0.323441299018667 no 2295 0.317095754864598 3319 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3273 9137859 49.47 µM -0.477106280779301 0.323014283508866 no 2296 0.31664322122302 3332 2377234
SGTC_2720 fluspirilene 36.88 µM -0.47742885364676 0.322905919691983 no 2297 0.316528385988877 3307 3396 An atypical antipsychotic.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.478431921810853 0.322569049139812 no 2298 0.316171408953671 3282 5379071
SGTC_1749 st037932 54.2 µM -0.478509431764508 0.32254302424299 no 2299 0.316143831439556 3338 594497
SGTC_1514 1189-1591 158 µM -0.479167748172513 0.322322021673853 no 2300 0.315909648188222 3396 767698 YMR146C TIF34
SGTC_3020 9089140 49.47 µM -0.480479443673456 0.321881861280298 no 2301 0.315443258313729 3356 17217859
SGTC_1126 isoteolin 1.0172 µM -0.484206939614475 0.320632405637785 no 2302 0.314119506187665 3237 133323
SGTC_169 k015-0017 16.025 µM -0.484874448703907 0.320408870636686 no 2303 0.313882704124005 3460 1840002
SGTC_3079 9117512 49.47 µM -0.486130288868914 0.319988492321918 no 2304 0.313437396548959 3331 7185044
SGTC_2826 7992541 19.48 µM -0.486336894413595 0.319919355565396 no 2305 0.313364162438177 3339 2985066
SGTC_1964 st076914 61 µM -0.487377822667259 0.319571123193333 no 2306 0.312995303409768 3321 24208661
SGTC_2378 9074213 121.43 µM -0.490662744803682 0.318473228557938 no 2307 0.31183250019469 3329 657714
SGTC_308 4092-1169 104 µM -0.492350501728003 0.317909760840459 no 2308 0.311235792327446 3276 2268590 YDL196W YDL196W
SGTC_3242 9133940 49.47 µM -0.495245695091507 0.316944165028285 no 2309 0.310213349367252 3390 17248444
SGTC_2832 7992762 51.95 µM -0.496700724398566 0.316459358003864 no 2310 0.309700055762912 3149 2985177
SGTC_458 nppb 133 µM -0.497261604884192 0.316272560123084 no 2311 0.309502291809971 3431 4549 A chloride channel blocker.
SGTC_454 lyso-paf C-16 6.67 µM -0.497332830783078 0.316248842118153 no 2312 0.309477181821705 3307 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_33 0986-0033 35.816 µM -0.497872778640748 0.316069065738643 no 2313 0.309286857465029 3338 2848082
SGTC_342 k048-0088 23.3 µM -0.498467797412791 0.315871003782909 no 2314 0.309077180603191 3252 6820570
SGTC_2520 obtusaquinone 4.71 µM -0.498833148443385 0.315749416763164 no 2315 0.308948466468579 3434 5967872
SGTC_1179 1021-1431 9.29 µM -0.499804188949909 0.315426356212858 no 2316 0.30860648038171 3325 2840958
SGTC_364 0083-0097 67.7 µM -0.500531483948514 0.315184480995883 no 2317 0.308350446525019 3380 5207356
SGTC_2195 6536160 144.242 µM -0.502006894156124 0.314694049823924 no 2318 0.307831335731225 3248 3834386
SGTC_2362 9071156 126 µM -0.5035440289499 0.314183448660861 no 2319 0.307290916469005 3397 653133
SGTC_3204 9114183 49.47 µM -0.503931623155424 0.31405475476638 no 2320 0.307154713731359 3242 17027248
SGTC_2752 diclazuril 33.15 µM -0.505227777180574 0.313624553725821 no 2321 0.306699431373081 3349 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1089 terbinafine 2.25 µM -0.505710069210452 0.313464542842506 no 2322 0.306530099278211 3383 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3328 9140624 29.0385 µM -0.506547331647046 0.313186846163679 no 2323 0.306236235629451 3395 4904392
SGTC_2561 acetosyringone 100 µM -0.506980956421708 0.31304306649795 no 2324 0.30608409031234 3239 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2299 7976368 114.88 µM -0.507694000365897 0.312806699887906 no 2325 0.30583397830575 3371 2979718
SGTC_2141 5621638 7.665 µM -0.509347930207484 0.312258735790478 no 2326 0.305254183618433 3395 2856238
SGTC_2190 6049624 200 µM -0.512891890563489 0.311085983459766 no 2327 0.304013473185617 3330 2265554
SGTC_102 gallobenzophenone 83.616 µM -0.514267526955939 0.310631279099262 no 2328 0.303532480971062 3443 70837
SGTC_857 0438-0306 1.35 µM -0.514663505098362 0.310500445612367 no 2329 0.303394089959982 3416 4686136
SGTC_1352 1496-0991 99 µM -0.514903790736833 0.310421065520724 no 2330 0.303310125909322 3320 3000039
SGTC_1308 1187-1617 41.4 µM -0.515032254937822 0.310378630068151 no 2331 0.303265240368688 3326 2882570
SGTC_1386 3228-0095 33.8 µM -0.515294240218371 0.31029209655216 no 2332 0.30317371161234 3398 870181
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.515777863861014 0.310132383661298 no 2333 0.303004782401644 3473 16725076
SGTC_1719 st032227 49.2 µM -0.516923092247538 0.309754323871674 no 2334 0.302604923444041 3305 3125804
SGTC_968 1309-0633 340 µM -0.517015120034423 0.309723952626415 no 2335 0.302572802011074 3385 3761976
SGTC_3207 9114163 49.47 µM -0.517293305969066 0.309632152892368 no 2336 0.302475713121698 3513 849233
SGTC_897 1000-0139 31.4 µM -0.518698409629172 0.309168658437477 no 2337 0.301985535454877 3412 6151020
SGTC_737 1950-0117 57.9 µM -0.51897741559115 0.309076660248821 no 2338 0.301888245258706 3402 5393513
SGTC_1988 st071872 53.4 µM -0.519274526214654 0.308978705472531 no 2339 0.301784657401301 3422 16414116
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.519399442485703 0.308937525724944 no 2340 0.301741110014544 3329 2374 Ca(2+)-ATPase inhibitor.
SGTC_407 eburnamonine 100 µM -0.520179832553281 0.308680317652958 no 2341 0.301469120179086 3313 3195
SGTC_2321 7390090 138.78 µM -0.520924645745313 0.308434922836636 no 2342 0.301209632928401 3315 649046
SGTC_2449 5812982 45.77 µM -0.521411943431504 0.308274418366136 no 2343 0.301039916586637 3384 776185
SGTC_2844 9010103 25.97 µM -0.526370193663634 0.306643374400428 no 2344 0.299315510488167 3434 2480525
SGTC_2919 7978188 46.38 µM -0.526694446850067 0.306536842314295 no 2345 0.299202896270841 3453 2980291
SGTC_3307 9126885 69.2785 µM -0.526924021115133 0.306461426491476 no 2346 0.299123175987231 3290 24824909
SGTC_1555 citronellol 128 µM -0.526969309794393 0.306446549994683 no 2347 0.299107450509729 3392 8842 A terpine precursor.
SGTC_1620 st003704 16.5 µM -0.527140110986587 0.306390447819901 no 2348 0.299048147005741 3425 2834414
SGTC_159 3970-0959 50 µM -0.527228867934581 0.306361296080939 no 2349 0.29901733201031 3490 6615653
SGTC_2723 salbutamol 83.58 µM -0.52723065991505 0.306360707527279 no 2350 0.299016709878148 3383 9884233 β2-adrenoceptor agonist
SGTC_2035 5154463 94.595 µM -0.527599554776763 0.306239559244826 no 2351 0.29888865104519 3436 2769623
SGTC_1579 chlormadinone acetate 49.4 µM -0.527646411078626 0.30622417274351 no 2352 0.29887238704689 3433 45114258 A steroidal progestin.
SGTC_2819 7996655 46.38 µM -0.528167772993106 0.30605299288483 no 2353 0.298691447502999 3309 6456960
SGTC_369 0957-0393 4.5 µM -0.530138341396788 0.305406374729894 no 2354 0.298008008656377 3360 6997992
SGTC_1082 camptothecin 424.86 nM -0.530609621496056 0.30525181968872 no 2355 0.297844663450654 3173 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_3251 9135047 49.47 µM -0.530943798570179 0.305142248249855 no 2356 0.297728862761075 3388 17682963
SGTC_1326 1431-2094 10.8 µM -0.531082444620706 0.305096793502145 no 2357 0.297680824476658 3303 616278
SGTC_884 0851-0618 334 µM -0.531156985436216 0.305072356731955 no 2358 0.297654998928895 3420 9642473
SGTC_1916 st067606 49.2 µM -0.531534641221197 0.304948562916905 no 2359 0.297524171327727 3365 19590279
SGTC_1433 4060-0023 7.6 µM -0.532415030920909 0.304660061940849 no 2360 0.297219288515502 3425 3840627
SGTC_844 0330-0132 15.3 µM -0.533191081928203 0.304405853132782 no 2361 0.296950657123637 3449 2828079
SGTC_1981 st071826 47 µM -0.53472692652821 0.303903039466446 no 2362 0.296419349584066 3379 11838600
SGTC_1520 flindersine 88 µM -0.535302921803548 0.30371456236164 no 2363 0.29622020314466 3506 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3037 9091026 49.47 µM -0.537358058252778 0.303042506409929 no 2364 0.295510154367753 3442 25236398 YIL048W NEO1
SGTC_3122 9126309 49.47 µM -0.538480228333091 0.302675823483094 no 2365 0.295122775737116 3447 17591206
SGTC_2838 9002687 71.43 µM -0.538941408240363 0.302525184910845 no 2366 0.294963641992636 3313 6457060
SGTC_677 0929-0063 136 µM -0.540008927833764 0.30217662216777 no 2367 0.294595437745323 3385 1539583
SGTC_131 0141-0277 33.849 µM -0.541914778944028 0.301554779007573 no 2368 0.293938607595529 3441 1547771
SGTC_2589 lobaric acid 100 µM -0.542774723318596 0.301274384045371 no 2369 0.293642459326756 3345 73157 A novel microtubule depolymerizer.
SGTC_441 propafenone 146 µM -0.543109434105055 0.301165279416387 no 2370 0.293527228737123 3366 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_603 3794-0023 45.9 µM -0.545703984078724 0.300320146601671 no 2371 0.292634716435405 3429 3802260
SGTC_2552 juarezic acid 87.02 µM -0.547023082021314 0.29989088311287 no 2372 0.292181437237765 3457 1549512
SGTC_305 1682-2595 20.8 µM -0.548059331055313 0.299553859797295 no 2373 0.29182558217415 3421 226033
SGTC_2841 9004761 38.96 µM -0.551358698316259 0.298481938869656 no 2374 0.290693903751096 3343 2991039
SGTC_2177 5811945 192 µM -0.551950248542259 0.298289936646316 no 2375 0.290491220033959 3466 5343475
SGTC_1640 st009078 66.4 µM -0.552141202979891 0.298227969679411 no 2376 0.290425807160744 3444 690618
SGTC_3289 9119912 71.43 µM -0.553194150762307 0.297886381044327 no 2377 0.290065235912051 3480 17014829
SGTC_323 4013-0906 34.3 µM -0.553838275535061 0.29767750738291 no 2378 0.289844765431792 3457 2910086
SGTC_1108 betulinic acid 729.144 nM -0.554346774579681 0.297512660994959 no 2379 0.289670772351005 3391 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1594 piperine 70.1 µM -0.554582880160568 0.297436133917464 no 2380 0.289590000790921 3416 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_667 1498-1044 59 µM -0.555907068881078 0.297007101557623 no 2381 0.289137192793047 3400 6739982
SGTC_2058 5236698 133 µM -0.558012029800445 0.296325685099518 no 2382 0.288418084796712 3369 766665
SGTC_1124 fisetin 1.16336 µM -0.55823778133436 0.296252647554602 no 2383 0.288341012434676 3387 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2656 pseudo-anisatin 100 µM -0.558309495321889 0.296229447608344 no 2384 0.288316531061455 3429 6708809 A neurotoxin.
SGTC_1334 1486-0610 236 µM -0.55843860757353 0.296187681047327 no 2385 0.288272457818201 3454 3742339
SGTC_3297 9117502 71.43 µM -0.560486100591027 0.295525698346216 no 2386 0.287573958858447 3447 7453720
SGTC_2957 9076800 11.52 µM -0.560824338767659 0.295416406795312 no 2387 0.287458646496415 3376 16459615
SGTC_1494 4358-1428 177 µM -0.561024788037775 0.295351646384269 no 2388 0.287390319532126 3495 1564571
SGTC_3129 9127257 49.47 µM -0.561597185620224 0.295166754252992 no 2389 0.287195249180784 3334 837894
SGTC_3282 9108498 15.4605 µM -0.561903424885286 0.295067856731989 no 2390 0.287090910049704 3415 16459645
SGTC_961 1252-1571 372 µM -0.563748524388234 0.294472319861163 no 2391 0.286462644254829 3500 6813498
SGTC_1188 1403-0014 4.57 µM -0.563795135014168 0.294457282685353 no 2392 0.28644678155123 3421 9614867
SGTC_272 doxorubicin 8.13 µM -0.564164407696256 0.29433816318993 no 2393 0.2863211240177 3453 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1057 3448-5381 134 µM -0.564612579251003 0.294193622499626 no 2394 0.286168653634429 3451 5497911
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.564880842608305 0.294107120048729 no 2395 0.286077407446498 3352 688803
SGTC_2710 st078562 53.7235 µM -0.567254033444914 0.293342388903566 no 2396 0.285270801053468 3419 17250908
SGTC_2118 5526350 200 µM -0.568751356832148 0.29286036970316 no 2397 0.284762444917351 3436 743594
SGTC_2075 5212009 200 µM -0.569082976964407 0.292753664112311 no 2398 0.284649915100388 3452 780898
SGTC_2085 5307070 144.047 µM -0.569464131623835 0.292631042074819 no 2399 0.284520602789132 3400 2840351
SGTC_1989 st071868 50.2 µM -0.570172057979193 0.292403356988826 no 2400 0.284280502863728 3477 16414057
SGTC_396 dithiazanine 1.25 µM -0.570653333600048 0.292248614938084 no 2401 0.284117329003284 3389 10578 An antihelmenthic.
SGTC_1996 st072960 66.8 µM -0.573144079849703 0.29144838762043 no 2402 0.283273571722957 3508 1719405
SGTC_3169 9102970 49.47 µM -0.574372181266226 0.291054199619095 no 2403 0.28285798682506 3506 17027839
SGTC_1495 4469-0029 237 µM -0.575063718608121 0.290832344119076 no 2404 0.28262410212868 3473 793680
SGTC_2437 5741531 144.16 µM -0.576904989023007 0.290242022889975 no 2405 0.282001820082939 3540 2262990
SGTC_2799 7812892 81.82 µM -0.57714625099477 0.290164714610053 no 2406 0.281920331286403 3507 20205235
SGTC_1474 0330-0125 5.35 µM -0.578678478136757 0.289673963944403 no 2407 0.281403070248804 3496 X1474
SGTC_2581 avocatin a 64 µM -0.579281106745751 0.289481057326278 no 2408 0.281199755806352 3421 6710728 A skin care supplement.
SGTC_1811 st050069 61.5 µM -0.58093001986665 0.288953534646829 no 2409 0.28064380945758 3483 3877702
SGTC_1 0258-0098 57.368 µM -0.583332833640257 0.288185633783788 no 2410 0.279834631759854 3408 6790032 YDR047W HEM12
SGTC_223 busulfan 5 mM -0.584396569686723 0.287845988464535 no 2411 0.279476767052236 3482 2478 A DNA alkylator.
SGTC_2587 piperic acid 92.2 µM -0.585961032036524 0.287346807649133 no 2412 0.278950850905729 3401 5370536
SGTC_488 nitrendipine 139 µM -0.586185631023749 0.287275177361042 no 2413 0.278875388316729 3505 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2966 9084041 48.03 µM -0.586906435845476 0.287045351595382 no 2414 0.278633273582156 3317 17741380
SGTC_482 fipronil 114 µM -0.588732114736288 0.286463631013179 no 2415 0.278020495520565 3526 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2703 st077852 53.4 µM -0.590572973613975 0.285877640610487 no 2416 0.277403288906724 3506 6281836
SGTC_682 0kpi-0099 17 µM -0.591202528710976 0.285677368691563 no 2417 0.277192364319413 3518 1714895 YML126C ERG13
SGTC_2622 2-methoxyxanthone 59.94 µM -0.591404617143927 0.285613095164806 no 2418 0.277124673748244 3462 71034 A hepatoprotective.
SGTC_356 1634-0012 32.5 µM -0.594313694771763 0.284688636476234 no 2419 0.276151160345542 3523 735457
SGTC_1993 st073995 70.8 µM -0.599013390369694 0.283198172704648 no 2420 0.27458197762629 3483 3098394
SGTC_2064 5220758 200 µM -0.600193897232936 0.282824375280777 no 2421 0.274188510180273 3570 788518
SGTC_1629 st005085 44.9 µM -0.600463801527703 0.282738945686403 no 2422 0.274098589177898 3474 24207091
SGTC_1855 st056195 39.6 µM -0.601024808008416 0.282561416659179 no 2423 0.273911731535548 3523 4028379
SGTC_280 3448-3607 3.04 µM -0.601290975580706 0.282477207377852 no 2424 0.273823099608695 3524 626179
SGTC_2440 5628896 157.78 µM -0.603317723763752 0.281836387122299 no 2425 0.273148672231811 3503 5522048
SGTC_99 0109-0120 622.8 µM -0.60373756181639 0.281703729744763 no 2426 0.273009068530693 3577 759414
SGTC_3299 9121982 43.1275 µM -0.605258089043249 0.281223536697629 no 2427 0.272503762115179 3485 17594604 YPL160W CDC60
SGTC_3154 9100113 49.47 µM -0.605837912027653 0.281040528729716 no 2428 0.2723111958893 3456 25237525
SGTC_222 nsc-310342 10.666 µM -0.6066827756878 0.280773969736916 no 2429 0.272030727531799 3501 432556
SGTC_96 0929-0093 37.281 µM -0.606940866350387 0.280692565141352 no 2430 0.271945078141986 3478 6991579
SGTC_353 1988-1175 58.3 µM -0.607375320475831 0.28055555938478 no 2431 0.271800931468703 3399 2788357
SGTC_3141 9094609 49.47 µM -0.607984821857141 0.280363406778062 no 2432 0.271598770321497 3430 25236309 YDL196W YDL196W
SGTC_2499 avocadenofuran 51.48 µM -0.608035893323515 0.280347308780998 no 2433 0.271581834192975 3413 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3197 9113331 49.47 µM -0.608153021286386 0.280310391116404 no 2434 0.27154299464253 3587 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1772 st048439 82.2 µM -0.608499567626872 0.280201176664285 no 2435 0.271428096321552 3506 2927068 YDL195W SEC31
SGTC_1723 st034307 2.5525 µM -0.608885365922077 0.280079616172277 no 2436 0.271300212413384 3520 867466
SGTC_2677 mitomycin C 100 µM -0.609031823329754 0.280033475865048 no 2437 0.271251672770901 3526 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1185 1319-0113 81.3 µM -0.610100350763488 0.279696955867903 no 2438 0.270897667154309 3536 4672763
SGTC_1843 st055809 45.5 µM -0.610958763766709 0.279426751144024 no 2439 0.270613440040013 3538 16413835
SGTC_1241 0364-0022 50.8 µM -0.611037313443326 0.279402032206603 no 2440 0.27058743908125 3489 4563895
SGTC_3014 9081533 49.47 µM -0.61529981014981 0.278062254667328 no 2441 0.269178371463382 3547 21367265
SGTC_1199 1638-0010 4.46 µM -0.617832779036 0.277267585475693 no 2442 0.268342786804742 3486 3111136
SGTC_586 0957-0265 8.15 µM -0.618130248359993 0.277174333258701 no 2443 0.268244742251927 3482 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2835 9006588 71.43 µM -0.618162519966564 0.277164217511835 no 2444 0.268234106759174 3573 2345538
SGTC_567 1080-0542 68.4 µM -0.6184125277181 0.277085857061939 no 2445 0.268151720912571 3512 5950415
SGTC_1605 st000082 49.1 µM -0.618524547202185 0.277050750079528 no 2446 0.268114810908705 3530 1114022
SGTC_457 grayanotoxin iii 135 µM -0.618526963548653 0.277049992818891 no 2447 0.268114014759696 3531 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3045 9092950 49.47 µM -0.618877947546301 0.276940008441914 no 2448 0.26799838356952 3587 44120432
SGTC_1887 st057648 70.8 µM -0.619372134692636 0.276785186162815 no 2449 0.267835616877782 3553 688672
SGTC_2093 5331342 194.4 µM -0.621517251148769 0.276113641493204 no 2450 0.267129673761663 3569 33839
SGTC_1220 1838-0075 193 µM -0.622064340333898 0.275942499251617 no 2451 0.266949780911719 3518 5529645
SGTC_2988 9073640 71.4286 µM -0.622188631410227 0.275903625372032 no 2452 0.266908920282497 3607 9102229
SGTC_1745 st081495 74 µM -0.622215692659929 0.275895161921028 no 2453 0.266900024329037 3536 13842402 YBL026W LSM2
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.622774970678843 0.275720275348644 no 2454 0.266716204159575 3625 6710655
SGTC_418 lividomycin a 100 µM -0.623745297654353 0.275416982859203 no 2455 0.266397434762485 3576 72394 An antibiotic.
SGTC_2414 st077232 92.9 µM -0.624776517855585 0.275094837159064 no 2456 0.266058872287093 3476 729801
SGTC_2466 5983409 37.09 µM -0.626483865897547 0.274561882345273 no 2457 0.265498808088553 3490 2879657
SGTC_1140 3229-1848 2.98 µM -0.627682873433124 0.274187912555783 no 2458 0.26510585348442 3557 2849525
SGTC_2598 perillyl alcohol 100 µM -0.628459121721536 0.273945935380816 no 2459 0.264851608758536 3576 10819 An apoptosis inducer.
SGTC_931 2812-0076 566 µM -0.628830274058959 0.273830274668396 no 2460 0.264730088987203 3564 3450959
SGTC_2162 5663267 200 µM -0.631958020745681 0.272856547743907 no 2461 0.263707154272414 3574 6456493
SGTC_1317 1273-0028 910 nM -0.632090343237417 0.272815391135392 no 2462 0.263663922476317 3543 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_428 3448-4153 16.5 µM -0.634002302336162 0.272221053466624 no 2463 0.263039659788634 3526 3834874
SGTC_1078 idebenone 36.1 µM -0.634175763261556 0.272167164522325 no 2464 0.262983061464522 3574 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2300 7976697 71.57 µM -0.636139787935786 0.271557372972425 no 2465 0.262342657146978 3493 2236109
SGTC_2439 5492030 7.2 µM -0.636239786416644 0.271526343597175 no 2466 0.262310072287792 3526 5722370
SGTC_2244 6635614 200 µM -0.636637297364559 0.27140301402435 no 2467 0.262180562439127 3458 836499
SGTC_3081 9117243 49.47 µM -0.638944517727402 0.270687740041697 no 2468 0.261429512995105 3607 45595589
SGTC_2582 agaric acid 100 µM -0.639579298829184 0.270491113334162 no 2469 0.261223072175999 3535 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_276 colchicine 750 µM -0.64052475654057 0.270198385316076 no 2470 0.260915749792218 3622 2833 A microtubule depolymerizer.
SGTC_1999 st074831 12.5 µM -0.640655749087913 0.27015784054004 no 2471 0.260873185147971 3538 17112523
SGTC_615 k087-0205 167 µM -0.64076900647234 0.270122787599674 no 2472 0.260836386236768 3542 9642773
SGTC_2638 epoxomicin 18 µM -0.64102896057541 0.270042340914637 no 2473 0.260751933605508 3556 9915668 A protesome inhibitor.
SGTC_1131 3454-3128 32.3 µM -0.641431167395561 0.26991789562539 no 2474 0.260621294330428 3566 710982
SGTC_757 1066-0008 322 µM -0.641655135769363 0.269848610863871 no 2475 0.260548562617091 3578 6842497
SGTC_2906 7926292 26.41 µM -0.642240865446195 0.269667457110463 no 2476 0.260358401590527 3585 2966319
SGTC_1005 4092-0690 4.4 µM -0.645853101631 0.268551617181371 no 2477 0.259187247209928 3549 1529343
SGTC_1462 k081-0014 26.5 µM -0.646122755795135 0.268468412689317 no 2478 0.259099929655226 3410 3270634
SGTC_1600 coumarin 106 71.1 µM -0.647511932311493 0.268039973848508 no 2479 0.258650337208688 3633 100336 A hepatotoxic, DNA x-linker.
SGTC_1389 3405-0187 19 µM -0.648472219469071 0.267744011017107 no 2480 0.258339786580599 3522 799890
SGTC_2534 helenine 20.12 µM -0.649311707734316 0.267485413665377 no 2481 0.258068459900169 3596 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2507 purpurin 79.67 µM -0.650127956354524 0.267234095919174 no 2482 0.257804786158765 3550 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2234 tolnaftate 200 µM -0.65024228976416 0.267198902908606 no 2483 0.257767864071412 3568 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_590 k048-0076 22.4 µM -0.6564859217193 0.265280606932893 no 2484 0.255755761429694 3609 6832814
SGTC_2812 7970281 58.44 µM -0.657851539544489 0.264861967730519 no 2485 0.255316766318495 3634 2233435
SGTC_405 ebelactone b 50 µM -0.658329315525392 0.26471558167055 no 2486 0.255163272250786 3597 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_594 1487-1584 10.8 µM -0.661667307934425 0.263694001371157 no 2487 0.254092230396692 3586 5013332
SGTC_254 nsc-64875 3.808 µM -0.66172027576014 0.26367780698618 no 2488 0.25407525395166 3630 56993
SGTC_2201 6605497 169.863 µM -0.661945568142669 0.263608931753379 no 2489 0.254003053298396 3618 670741
SGTC_2431 5490079 200 µM -0.665393838963512 0.262555890733238 no 2490 0.252899312268561 3635 5722345
SGTC_3221 9128209 49.47 µM -0.667428339458296 0.261935601634518 no 2491 0.252249284481274 3638 16460723
SGTC_917 harmaline 728.087 nM -0.668853893474571 0.261501419453546 no 2492 0.251794342023437 3601 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_888 0916-0002 6.97 µM -0.669508954185206 0.261302031042255 no 2493 0.251585435376406 3662 2802138 YIL048W NEO1
SGTC_843 0310-0051 143 µM -0.669900787334649 0.261182801591814 no 2494 0.251460518907358 3635 2065037
SGTC_533 1222-0222 6.71 µM -0.674294054752824 0.259847907240364 no 2495 0.250062191531233 3690 3982874
SGTC_2338 7999974 200 µM -0.674307689345786 0.259843769854857 no 2496 0.250057858225077 3680 315925
SGTC_173 1273-0061 2.693 µM -0.674352816464581 0.259830076378073 no 2497 0.250043516341308 3592 2847414 YPL266W DIM1
SGTC_2350 9023895 38.85 µM -0.674459940765296 0.259797571824722 no 2498 0.250009472833978 3637 2997209
SGTC_655 k060-0012 42 µM -0.675112612761935 0.259599577960067 no 2499 0.249802110452403 3597 5994525
SGTC_1513 0337-0559 19 µM -0.675238555560321 0.259561381058939 no 2500 0.249762107300263 3569 775073
SGTC_2385 9074692 200 µM -0.675294558123857 0.259544397102638 no 2501 0.249744320324826 3623 17046906
SGTC_2711 st079103 59.1 µM -0.675456299371134 0.25949534888675 no 2502 0.249692953460555 3626 54693780
SGTC_1849 st056239 19.2 µM -0.681081979681511 0.257792338677982 no 2503 0.247909809409875 3606 5393181
SGTC_2918 7977171 22.06 µM -0.683177646988374 0.25715942284477 no 2504 0.247247297766223 3604 2236483
SGTC_1625 st003711 30.1 µM -0.684160804997512 0.256862776403272 no 2505 0.246936814660793 3697 24207034 YER133W GLC7
SGTC_1247 0448-0043 5.84 µM -0.684409853939382 0.256787659607213 no 2506 0.246858197682085 3686 3089013 YGL099W LSG1
SGTC_43 0570-0105 72.5 µM -0.68555872952511 0.256441290054438 no 2507 0.24649570702908 3686 1114046 YDL195W SEC31
SGTC_1292 0kpi-0043 232 µM -0.685931581819766 0.256328932765228 no 2508 0.246378126835093 3654 3333905
SGTC_2747 doxorubicin 7.63 µM -0.688120342839743 0.255669877676109 no 2509 0.245688500475313 3557 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3331 9141060 1.957 µM -0.690080446851132 0.255080425124834 no 2510 0.245071799339662 3658 4906567 YPR165W RHO1
SGTC_352 k048-0007 5.11 µM -0.690715897312556 0.254889481893543 no 2511 0.244872048502548 3649 6811911
SGTC_2698 st077697 67.5 µM -0.69135782612133 0.254696667997653 no 2512 0.244670350227374 3611 3154499
SGTC_1735 st034310 56.75 µM -0.69205443189813 0.254487517418766 no 2513 0.244451573341936 3730 871153
SGTC_2014 4013930 200 µM -0.692756542361852 0.254276805194937 no 2514 0.244231174345438 3645 64556
SGTC_2623 humulene 100 µM -0.694652637407391 0.253708220485667 no 2515 0.243636508186224 3613 6187145 An anti-inflammatory.
SGTC_2605 digitonin 300 nM -0.694816721542329 0.253659047750826 no 2516 0.243585083792653 3708 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2992 9074591 71.4286 µM -0.694823343691332 0.253657063330247 no 2517 0.243583008517045 3662 17741321
SGTC_1196 1588-0294 184 µM -0.695457926735758 0.25346693938192 no 2518 0.243384184645137 3665 6144269
SGTC_3104 9120930 49.47 µM -0.695986119011422 0.253308747711654 no 2519 0.243218761406869 3668 17014836
SGTC_2326 6164455 177.58 µM -0.70049054417336 0.251961800261841 no 2520 0.241810504177157 3659 2888790
SGTC_2067 5224629 34.075 µM -0.701720525688264 0.251594659894527 no 2521 0.241426734962311 3668 2835000
SGTC_1327 1436-0082 2.18 µM -0.702475972741956 0.251369304719396 no 2522 0.241191190386511 3680 15992205
SGTC_2304 7443016 91.4 µM -0.70362041094526 0.251028114108516 no 2523 0.240834598410925 3637 939854
SGTC_1652 st011932 78 µM -0.704381905204846 0.250801226162656 no 2524 0.240597485777839 3638 1551076
SGTC_777 1315-0167 517 µM -0.704754404563424 0.250690279179283 no 2525 0.24048154394349 3679 4221767
SGTC_2045 5106652 78.05 µM -0.706248735053132 0.250245462089883 no 2526 0.240016733934113 3658 673349
SGTC_2873 9040596 71.43 µM -0.707075231382492 0.249999618950446 no 2527 0.239759863618418 3667 6463863
SGTC_2409 alverine citrate 63.97 µM -0.707952655290979 0.249738767603904 no 2528 0.239487329530823 3812 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1642 st009582 77.7 µM -0.708536568263312 0.2495652549186 no 2529 0.239306055803161 3689 6739311
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.709627649760942 0.249241206273869 no 2530 0.23896753437066 3736 688788
SGTC_2446 5162541 200 µM -0.710026821233281 0.249122709208847 no 2531 0.23884375196994 3663 1549321
SGTC_1291 0993-0025 5.79 µM -0.710478558103737 0.248988643863744 no 2532 0.238703711439157 3712 4353356
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.711365041414846 0.248725667182926 no 2533 0.238429028125424 3755 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1984 st072354 53.1 µM -0.71350582363523 0.248091211103228 no 2534 0.237766405381349 3630 5762938
SGTC_3093 9117344 49.47 µM -0.714285554345218 0.247860339734483 no 2535 0.237525311467051 3717 24824913
SGTC_1427 4048-4900 550 nM -0.717681264405537 0.246856238700561 no 2536 0.236476919008265 3713 24132586
SGTC_929 2805-0021 398 µM -0.718274672311875 0.246680993565377 no 2537 0.236293971858923 3763 3098024
SGTC_758 0868-0029 16 µM -0.71896110716547 0.246478358864069 no 2538 0.236082441834926 3725 762687
SGTC_1856 st057054 55.7 µM -0.720919954126252 0.245900600462101 no 2539 0.235479382555289 3738 1266018
SGTC_2048 5246248 200 µM -0.721576646468074 0.245707073031186 no 2540 0.235277400767403 3688 677046
SGTC_838 0109-0203 71.4 µM -0.722416477340395 0.245459693843873 no 2541 0.235019229687874 3718 759422
SGTC_2373 9071805 200 µM -0.72365798091512 0.245094243891291 no 2542 0.234637867898452 3695 10149009
SGTC_1539 benzyladenosine 56 µM -0.724924049547291 0.244721864545857 no 2543 0.234249312983622 3699 92208 A nucleotide analog.
SGTC_54 0159-0055 9 µM -0.725169311011337 0.244649762852554 no 2544 0.23417408374529 3739 3319099
SGTC_851 0394-0702 453 µM -0.727231980382802 0.244043834511746 no 2545 0.23354192918072 3711 762646
SGTC_705 1124-0212 310 µM -0.728451725731175 0.243685904182654 no 2546 0.233168554679297 3696 9554485
SGTC_3344 9148862 3.898 µM -0.728467500455628 0.243681276998005 no 2547 0.233163728072454 3725 4905352
SGTC_34 0469-0683 81.75 µM -0.72865918395032 0.243625054454795 no 2548 0.233105082930476 3709 3690923
SGTC_2132 5317594 122.667 µM -0.731921346415011 0.242669306887221 no 2549 0.232108288150399 3709 794577
SGTC_218 alverine citrate 93.75 µM -0.732160006283062 0.2425994641526 no 2550 0.232035455883631 3751 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_448 monastrol 171 µM -0.732232397624085 0.242578281304727 no 2551 0.232013366601471 3650 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_949 1165-0505 146 µM -0.734156299958252 0.242015684348849 no 2552 0.231426741887226 3770 6244267
SGTC_555 4296-0685 37 µM -0.737039101019416 0.241174007831946 no 2553 0.230549285712674 3707 2908540 YHR072W ERG7
SGTC_2041 5107442 45.335 µM -0.738631207992937 0.240709851508621 no 2554 0.230065484250891 3731 793005
SGTC_3253 9135987 49.47 µM -0.73965688686457 0.240411086993212 no 2555 0.22975410722756 3732 4182430
SGTC_1222 0366-0074 1.18 µM -0.740726038795375 0.240099874568805 no 2556 0.229429783956162 3778 286520
SGTC_2398 5228213 48.84 µM -0.741931824242047 0.239749154061239 no 2557 0.229064321482127 3738 80771 YMR134W ERG29
SGTC_2941 9056145 11.23 µM -0.742146847760538 0.239686640676983 no 2558 0.228999184160077 3625 2119517
SGTC_2597 laccaic acid a 100 µM -0.743637558497535 0.239253493846777 no 2559 0.228547887321134 3749 5491415 A textile dye.
SGTC_1970 st070122 35.8 µM -0.744725036045019 0.238937782039569 no 2560 0.228218980444826 3744 102928
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.744757035310982 0.238928495601739 no 2561 0.228209306319536 3711 4620898
SGTC_2643 anethole 100 µM -0.745066064654253 0.238838823021164 no 2562 0.228115891398108 3753 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2052 5265182 7.135 µM -0.746460111249498 0.238434534502154 no 2563 0.22769475946895 3743 1239884
SGTC_1863 st057641 20.1 µM -0.747171769937082 0.238228290383238 no 2564 0.227479941103759 3763 3921635
SGTC_168 3970-0862 530.542 µM -0.747329800053823 0.238182505314099 no 2565 0.227432254275356 3754 3135186
SGTC_2119 5528445 120.635 µM -0.748019426723238 0.237982760566692 no 2566 0.227224219930276 3766 791935
SGTC_2334 9017922 200 µM -0.75031749908353 0.237317805966391 no 2567 0.22653175290248 3804 3163164
SGTC_2967 9089538 49.85 µM -0.751544801156632 0.236963100572206 no 2568 0.226162424493275 3762 728216
SGTC_1913 st060213 96.1 µM -0.75215915309487 0.236785654811403 no 2569 0.225977677235752 3772 688959
SGTC_3066 9117245 49.47 µM -0.752268224950261 0.236754158785296 no 2570 0.225944886184896 3828 17176980
SGTC_445 e6 berbamine 66 µM -0.753518022918342 0.236393426623895 no 2571 0.225569342575149 3842 6610268 A calcium/calmodulin antagonist.
SGTC_2341 7987486 176.74 µM -0.756151501606356 0.235634310840256 no 2572 0.22477918330766 3752 1258686
SGTC_1809 st050081 57.6 µM -0.757688979708002 0.235191746104564 no 2573 0.224318598936136 3810 5036894
SGTC_1716 st033144 30.6155 µM -0.760112340282384 0.234495112028072 no 2574 0.223593718460479 3757 674617
SGTC_1079 idarubicin 2.36 µM -0.760176002707538 0.23447682663829 no 2575 0.223574693603189 3734 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1755 st041960 45.185 µM -0.761848303910002 0.233996783870956 no 2576 0.223075273520112 3806 2257073
SGTC_862 0452-0056 10.2 µM -0.76405254459777 0.233364877648522 no 2577 0.22241796527668 3722 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_189 3970-0742 2.116 µM -0.764138730689267 0.233340189283696 no 2578 0.222392286901422 3764 2891807
SGTC_3182 9108849 49.47 µM -0.764704512062444 0.233178154842833 no 2579 0.222223759393076 3793 17133045
SGTC_1602 st001878 87.6 µM -0.765137761679542 0.233054118484138 no 2580 0.222094757982947 3790 595405 YLR310C CDC25
SGTC_3010 9080089 71.4286 µM -0.765392322822456 0.232981256486566 no 2581 0.222018981558012 3773 17027233
SGTC_2137 5261020 140 µM -0.765999322140219 0.232807568609357 no 2582 0.221838352760801 3748 763655
SGTC_3067 9117431 49.47 µM -0.766042607685668 0.232795185554294 no 2583 0.221825475202067 3822 17150885
SGTC_815 1582-0027 36.9 µM -0.767440750991526 0.232395403989345 no 2584 0.221409753746879 3824 3128206
SGTC_430 0958-0115 16.4 µM -0.7699878365973 0.231668079274382 no 2585 0.220653553960987 3773 6833180
SGTC_2944 9067346 25.62 µM -0.770014898016881 0.231660358655317 no 2586 0.220645527694327 3715 6473075
SGTC_3145 9085516 49.47 µM -0.771261171473161 0.231304952417497 no 2587 0.220276071162553 3849 25236195
SGTC_1029 k015-0030 64.7 µM -0.77156405050678 0.231218624799944 no 2588 0.220186336577901 3880 2208316
SGTC_2611 pyromycin 23.93 µM -0.773092580421261 0.230783232352642 no 2589 0.219733795912969 3803 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2558 carylophyllene oxide 100 µM -0.773948546913268 0.230539615658766 no 2590 0.219480609594621 3878 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1489 4065-0444 182 µM -0.774300855066774 0.230439386972811 no 2591 0.219376449075003 3738 2877968
SGTC_1416 3966-0321 25.3 µM -0.774361563435904 0.230422118416666 no 2592 0.219358503409288 3812 582530 YLR208W SEC13
SGTC_3143 9086658 49.47 µM -0.775533233164758 0.230088977545982 no 2593 0.219012317881793 3874 25236626
SGTC_2493 resveratrol 26.09 µM -0.77661188276485 0.229782523485408 no 2594 0.218693894366002 3694 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.777678031078222 0.229479845879039 no 2595 0.218379423312616 3799 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1379 2144-0755 36.5 µM -0.778800213326706 0.229161501826784 no 2596 0.21804870602808 3861 5392327
SGTC_3063 1327-0034 4 µM -0.779745757823165 0.228893459283068 no 2597 0.217770269756051 3681 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_25 0118-0223 35.662 µM -0.78033369665303 0.2287268793966 no 2598 0.21759724176407 3808 5333628
SGTC_1503 4585-0012 61.3 µM -0.782355088689201 0.228154680814413 no 2599 0.217002960004044 3821 2922052
SGTC_1630 st005209 31.3 µM -0.7826099871828 0.228082583491328 no 2600 0.216928087448686 3770 3367314
SGTC_2303 7774051 200 µM -0.782905585391301 0.227998990414833 no 2601 0.21684127867309 3766 2953184
SGTC_2962 9082311 13.18 µM -0.78307094496863 0.227952235416917 no 2602 0.216792726035821 3809 16459453
SGTC_1813 st051246 8.6015 µM -0.784805086717937 0.227462236271537 no 2603 0.216283928630116 3725 5291959
SGTC_2480 5767542 37.17 µM -0.787351768026292 0.226743722441112 no 2604 0.215537986473325 3809 2867358
SGTC_3092 9117248 49.47 µM -0.787374584307571 0.226737290910432 no 2605 0.215531310163233 3872 17141857
SGTC_2788 5282734 71.43 µM -0.787805147191336 0.226615941687638 no 2606 0.215405344928985 3862 743706
SGTC_1937 st074714 47.2 µM -0.788297619507147 0.226477188954443 no 2607 0.215261319882403 3771 17250970
SGTC_180 1486-1293 102.781 µM -0.78862022037998 0.226386323047202 no 2608 0.215167004565651 3768 4140536
SGTC_1911 st060208 74.3 µM -0.789009105960972 0.226276814323422 no 2609 0.215053342200792 3873 688783
SGTC_447 ml7 120 µM -0.78937211469807 0.226174619432152 no 2610 0.214947274512604 3838 4216 Selective myosin light chain kinase inhibitor.
SGTC_1891 st059073 26.2 µM -0.789441559010905 0.226155072313027 no 2611 0.214926987009884 3847 688754
SGTC_569 4130-2812 160 µM -0.789864860585641 0.22603594243542 no 2612 0.214803347489791 3672 743552
SGTC_932 2857-0803 154 µM -0.791243543685025 0.225648185281318 no 2613 0.214400943106913 3922 674898
SGTC_3322 9139058 2.11 µM -0.793424382112501 0.225035589698129 no 2614 0.213765304915362 3939 4908926 YPR165W RHO1
SGTC_510 ag-490 170 µM -0.795211478108594 0.224534299358682 no 2615 0.213245248049259 3935 5328779
SGTC_284 0988-0104 32.6 µM -0.79701024634607 0.224030375313565 no 2616 0.212722540273333 3827 4666532
SGTC_3219 9131112 49.47 µM -0.797824094792103 0.223802587344995 no 2617 0.212486288387378 3789 17612988 YMR079W SEC14
SGTC_2282 7944268 200 µM -0.798358472731309 0.22365309197949 no 2618 0.212331247332223 3820 2970414
SGTC_2460 5552655 174.22 µM -0.798606146324087 0.223583823100209 no 2619 0.212259411300291 3828 5401989
SGTC_3007 9078383 71.4286 µM -0.800348282363733 0.22309693069234 no 2620 0.211754518181286 3814 6496995
SGTC_1907 st060210 83.7 µM -0.801412348956053 0.222799842455835 no 2621 0.211446484212677 3868 688793
SGTC_1636 st007707 68.9 µM -0.801436262970349 0.222793168235241 no 2622 0.211439564420984 3831 403051
SGTC_1013 4112-3890 241 µM -0.80400159419637 0.222077865609626 no 2623 0.210698027159106 3795 705171
SGTC_3188 9110789 49.47 µM -0.804171333143484 0.222030582835592 no 2624 0.210649016118195 3824 849217
SGTC_1356 1502-0781 85.8 µM -0.807612604554154 0.221073216545004 no 2625 0.209656814193878 3807 567702
SGTC_2636 apigenin dimethyl ether 100 µM -0.807921000601629 0.220987535841273 no 2626 0.209568030528279 3855 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1093 fluphenazine 7.97 µM -0.809186644073771 0.220636105220476 no 2627 0.209203898051966 3858 6602611 An atypical antipsychotic.
SGTC_3268 9137683 49.47 µM -0.810814218080293 0.220184648440537 no 2628 0.208736184086002 3879 1953228
SGTC_3284 9108171 64.8615 µM -0.811694413608936 0.219940720524075 no 2629 0.208483500325673 3828 8687505
SGTC_1015 4130-4525 82 µM -0.812528652541463 0.219709671724169 no 2630 0.208244176216875 3860 1363237
SGTC_568 1193-0097 7.48 µM -0.813626109626539 0.219405935012643 no 2631 0.20792958782946 3726 3646150
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.816459136836936 0.218622971064305 no 2632 0.207118792851788 3882 5282362
SGTC_2197 6588183 93.1375 µM -0.818437894188746 0.218077057118351 no 2633 0.206553595649143 3799 884136
SGTC_3013 9080133 71.4286 µM -0.820256890747013 0.217575913030766 no 2634 0.206034838095268 3918 17050193
SGTC_1058 3448-5425 97.3 µM -0.820378497960315 0.217542433258138 no 2635 0.206000184648502 3750 7279705
SGTC_2294 7971431 200 µM -0.822328599792682 0.217005955570725 no 2636 0.205444951861952 3831 5741572
SGTC_2845 9003024 42.97 µM -0.823919042857488 0.216568987501484 no 2637 0.204992779728436 3891 2990173
SGTC_1115 galangin 695.678 nM -0.823957176045722 0.216558516808398 no 2638 0.204981945510555 3898 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3335 9143315 29.6265 µM -0.823984868864915 0.216550913037947 no 2639 0.204974077773436 3863 4899691
SGTC_3337 9144342 33.5465 µM -0.824331153159655 0.216455844887553 no 2640 0.204875710973273 3879 17682949
SGTC_2635 hydroquinidine 100 µM -0.82464930986581 0.216368520118013 no 2641 0.204785358947104 3812 442912 An experimental heart treatment.
SGTC_3126 9127922 49.47 µM -0.826132628660563 0.21596166145763 no 2642 0.204364430189862 3876 45595682
SGTC_2023 5144124 124 µM -0.826332346218408 0.215906914921522 no 2643 0.204307794714487 3871 2830192
SGTC_1558 st069300 45.6 µM -0.826693302819156 0.215807989975711 no 2644 0.204205459128447 3789 24208000
SGTC_2037 5169046 200 µM -0.830153940724657 0.214860890403036 no 2645 0.203225876414875 3941 5718022
SGTC_59 0330-0160 1.33 µM -0.83042971272748 0.214785521754737 no 2646 0.203147936075466 3839 4293482
SGTC_830 4076-0286 57.8 µM -0.832448993484951 0.214234119358257 no 2647 0.202577778721835 3941 6866659
SGTC_1968 st069590 43.6 µM -0.832587349805841 0.214196368746231 no 2648 0.202538747940245 3882 6384066
SGTC_2301 7769476 200 µM -0.832806928934396 0.214136464384422 no 2649 0.202476813162138 3925 977820
SGTC_1701 st028638 40.4 µM -0.834518043591567 0.213669981662213 no 2650 0.20199456196098 3835 3490878
SGTC_399 oxolinic acid 75 µM -0.835008105869416 0.213536490402908 no 2651 0.201856572232791 3845 4628 A DNA gyrase inhibitor.
SGTC_2568 diosmetin 100 µM -0.835935025728118 0.213284133595195 no 2652 0.201595728319029 3923 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1935 st074532 41.6 µM -0.836778443754572 0.213054661595034 no 2653 0.201358558154178 3904 2829742
SGTC_2344 7990960 76.95 µM -0.837444360576313 0.212873584830909 no 2654 0.201171419748218 3865 140813
SGTC_2243 6634756 200 µM -0.83832654466496 0.212633838825873 no 2655 0.200923665779335 3938 885676
SGTC_980 1473-0395 201 µM -0.839530299035854 0.212306956049859 no 2656 0.200585896993918 3785 768876
SGTC_290 2043-6722 48.1 µM -0.840278818850983 0.21210384163021 no 2657 0.200376037274973 3918 773758 YLR208W SEC13
SGTC_2337 9009472 200 µM -0.841969952923165 0.211645362897766 no 2658 0.199902386188019 3846 5742383
SGTC_106 0092-0003 11.579 µM -0.843830100471004 0.211141733954978 no 2659 0.199382176337995 3820 1072148
SGTC_1275 0867-0008 21.1 µM -0.84506412731409 0.210808013027656 no 2660 0.199037517882829 3859 3422836
SGTC_1263 0774-1208 64.8 µM -0.8456224106311 0.210657136783594 no 2661 0.198881709737617 3896 906585
SGTC_2074 5212007 75.395 µM -0.845797704511273 0.210609776628957 no 2662 0.198832803125893 3751 758611
SGTC_1904 st060225 78 µM -0.847479996668723 0.210155579876211 no 2663 0.198363816016087 3853 66595
SGTC_2314 7727897 200 µM -0.848581341877348 0.209858543041202 no 2664 0.198057146377261 3916 900724
SGTC_362 0310-0100 9.03 µM -0.85290891289578 0.20869377367329 no 2665 0.196854909321726 3994 790235
SGTC_484 loperamide 105 µM -0.854869135962285 0.208167434321632 no 2666 0.196311799393465 3884 3955 An opioid-receptor agonist.
SGTC_1748 st037455 53.6035 µM -0.860028691652659 0.206785792383471 no 2667 0.194886613406358 3955 580690
SGTC_1313 1220-0047 237 µM -0.860073334372037 0.206773861555246 no 2668 0.194874309598106 3906 3528706
SGTC_2798 7813637 45.45 µM -0.860730890964514 0.206598175864187 no 2669 0.194693137681328 3935 956368
SGTC_2225 6654152 15.4 µM -0.861906158153961 0.206284388786016 no 2670 0.194369579985255 3797 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3277 9138724 49.47 µM -0.862470655638392 0.206133772881671 no 2671 0.194214287092235 3857 15943418
SGTC_1678 st019265 80.2 µM -0.863081144204358 0.205970959315421 no 2672 0.194046427159071 3913 5367020
SGTC_2090 5301565 104.445 µM -0.863229622267193 0.205931372658615 no 2673 0.194005614998873 3919 2056344
SGTC_636 0kpi-0074 126 µM -0.863965471852983 0.205735249856509 no 2674 0.193803429248711 3936 616434
SGTC_2857 9024691 58.44 µM -0.864607645729282 0.205564184646058 no 2675 0.193627087311198 4004 16478292
SGTC_3225 9130819 49.47 µM -0.864909396746998 0.205483832002297 no 2676 0.193544259818102 3863 4547121
SGTC_2545 solidagenone 89.61 µM -0.866880893607209 0.204959305404547 no 2677 0.193003636597787 3730 6708572 An anti ulcer agent
SGTC_95 0471-0001 561.058 µM -0.867427041846548 0.204814140853756 no 2678 0.192854035275943 3916 4015405
SGTC_1205 4161-2785 76 µM -0.869230149526871 0.204335314638789 no 2679 0.192360629898537 4030 3498106
SGTC_2415 st077333 57.7 µM -0.870264151098986 0.204061030161226 no 2680 0.192078032580838 3904 2766255
SGTC_363 0455-0021 3.06 µM -0.870488722735703 0.204001488159324 no 2681 0.192016689729233 3923 4597466
SGTC_3296 9122258 64.045 µM -0.871349682424805 0.203773312773569 no 2682 0.191781625447681 3950 4730474
SGTC_1467 k284-1082 293 µM -0.872402663146292 0.203494454032867 no 2683 0.19149437409403 3875 3334705
SGTC_2135 5326629 150.42 µM -0.872910794950337 0.203359967988958 no 2684 0.191355850945154 3906 5020077
SGTC_1071 trifluoperazine 6.31 µM -0.87429012715367 0.202995170860678 no 2685 0.190980137283301 4042 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1660 st012960 28.1 µM -0.874805481345395 0.202858973559995 no 2686 0.190839877128269 3929 24207266
SGTC_109 0132-0036 33.701 µM -0.875394284793482 0.202703431991708 no 2687 0.19067970420785 3752 67274 A color developer.
SGTC_2867 9039098 71.43 µM -0.875778629634204 0.202601939791717 no 2688 0.190575194933665 3902 6463460
SGTC_647 0140-0236 81 µM -0.877008893473042 0.202277273873253 no 2689 0.190240903767565 3945 990837
SGTC_164 4100-3994 89.624 µM -0.877513728988072 0.20214413817351 no 2690 0.190103832577872 3890 4615967
SGTC_17 0960-0276 49.807 µM -0.880745475974195 0.201293101644991 no 2691 0.189227798430185 3929 6821114
SGTC_377 3970-0964 33.1 µM -0.884182330842038 0.200390413503985 no 2692 0.188298897457952 3919 16481235
SGTC_891 0929-0073 133 µM -0.885107378125142 0.200147866284693 no 2693 0.188049360245334 4022 5603632
SGTC_1742 st038235 28.8875 µM -0.886136536212624 0.199878228689499 no 2694 0.187771978503182 4005 564103 YBR002C RER2
SGTC_2086 5274770 176.623 µM -0.886173515691767 0.199868544199141 no 2695 0.187762016389733 4014 689278
SGTC_1777 st045864 34.765 µM -0.88957076159489 0.198980049776794 no 2696 0.186848205860465 3920 4691462
SGTC_1717 st033143 58.0435 µM -0.891379021799184 0.198508100897219 no 2697 0.186362934072703 3990 674616
SGTC_774 k060-0086 136 µM -0.894126916576666 0.197792205185419 no 2698 0.185626994632538 3918 5911235
SGTC_1180 1193-0155 285 µM -0.894884430238797 0.197595128452106 no 2699 0.18542443530175 4023 2921347
SGTC_2953 9074162 66.49 µM -0.895247512436928 0.197500710135385 no 2700 0.185327395699196 3933 16451992
SGTC_1208 2323-2347 50.3 µM -0.895654853645415 0.197394814885225 no 2701 0.185218564697147 3975 5412760
SGTC_1906 st060206 94.7 µM -0.896891669996435 0.197073493987875 no 2702 0.184888362735418 3986 5133468
SGTC_1529 apigenin 74 µM -0.897174120802256 0.197000158602938 no 2703 0.184813006109594 3970 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1794 st048918 76.9 µM -0.897411833949084 0.196938451683947 no 2704 0.184749600089948 3854 672303
SGTC_2593 nobiletin 86.24 µM -0.897765762231972 0.196846598667695 no 2705 0.184655220679241 3995 72344 An anti-infammatory.
SGTC_1287 0971-0001 34.6 µM -0.901524504636503 0.195872714796839 no 2706 0.183654755464971 3959 4665869
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.903497488351813 0.195362690215756 no 2707 0.183130960332381 3979 6728940
SGTC_3164 9100705 49.47 µM -0.905603220671795 0.1948192405024 no 2708 0.182572951750276 4012 17174235
SGTC_1763 st044482 94.5 µM -0.906004141760746 0.194715874640987 no 2709 0.182466830115575 4000 88505
SGTC_2676 harmalol 100 µM -0.907762373891511 0.194262959670591 no 2710 0.182001890780758 3920 5459187 A monoamine oxidase inhibitor
SGTC_1217 1183-1422 255 µM -0.909267348447664 0.1938757930801 no 2711 0.181604510743825 4004 2849664
SGTC_2475 5812728 15.03 µM -0.909892455063817 0.193715117802443 no 2712 0.181439614593105 3945 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1288 0973-0013 65.5 µM -0.910429507224144 0.193577140602064 no 2713 0.181298021106514 4025 4315430
SGTC_2079 5212404 121 µM -0.910944995307974 0.193444759946033 no 2714 0.181162178077931 3935 758462
SGTC_515 4092-1064 102 µM -0.913322304059114 0.192834966750373 no 2715 0.180536527595867 4013 717353
SGTC_3087 9117406 49.47 µM -0.913518199316936 0.192784770926027 no 2716 0.180485033183402 4012 42546093
SGTC_170 4197-0004 226 µM -0.913593117071016 0.192765576255145 no 2717 0.180465342208657 4028 218692
SGTC_631 k072-0230 41.5 µM -0.91531142133437 0.192325650250983 no 2718 0.180014082438641 4008 5773147
SGTC_3193 9111931 49.47 µM -0.917757675617444 0.191700412339539 no 2719 0.179372872508632 4006 17087244
SGTC_986 1493-0483 84 µM -0.917766228335938 0.19169822853691 no 2720 0.179370633200046 3911 40079
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.918715866836089 0.191455847994151 no 2721 0.179122104200728 4077 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2790 5423970 71.43 µM -0.920447823870673 0.191014276547245 no 2722 0.178669393476183 4081 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2402 5553605 200 µM -0.921291036055914 0.190799521480686 no 2723 0.178449249925286 4083 6758546
SGTC_947 3447-0010 211 µM -0.921789188904628 0.190672718139407 no 2724 0.178319273858632 3950 748350
SGTC_773 4358-1457 44.6 µM -0.922267903273089 0.190550911554371 no 2725 0.178194425826219 3954 1186886
SGTC_475 α-linolenic acid 10 µM -0.924645830431135 0.189946567652977 no 2726 0.177575082611894 4007 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1312 1218-2183 165 µM -0.925500853765135 0.189729554054642 no 2727 0.177352719901758 4009 6744073
SGTC_1720 st037298 9.481 µM -0.925566340128263 0.189712939240385 no 2728 0.177335696360404 4029 597396
SGTC_941 3237-0776 460 µM -0.926583298881467 0.189455037323416 no 2729 0.177071464754694 4050 760008
SGTC_426 0988-0037 14.6 µM -0.927099511593988 0.189324207778223 no 2730 0.176937434858083 4034 5383008
SGTC_516 3992-2719 87.3 µM -0.928688165368386 0.18892192659566 no 2731 0.176525357860907 3943 5350887 YDR037W KRS1
SGTC_200 k038-0079 37.545 µM -0.931967589362662 0.188093173359492 no 2732 0.175676637717361 3970 3436683
SGTC_244 nsc-207895 1.295 µM -0.932190618682497 0.188036892549311 no 2733 0.175619011421993 3804 42640
SGTC_1229 0139-0193 12.2 µM -0.93341357373089 0.187728468159644 no 2734 0.175303237360313 4074 3090752
SGTC_607 4491-0986 66.8 µM -0.934060839719078 0.187565356790745 no 2735 0.175136255330788 4030 698981 YDR232W HEM1
SGTC_761 k216-0224 480 µM -0.936473511800478 0.186958134096362 no 2736 0.174514722178982 4015 1340404
SGTC_1899 st063254 59.6 µM -0.940831011202782 0.185864522495511 no 2737 0.173395733066119 3961 3093813
SGTC_3055 9094636 49.47 µM -0.941315300824383 0.185743224661459 no 2738 0.173271651983664 4041 25236176
SGTC_2980 9014342 25.29 µM -0.941374443669239 0.185728414785637 no 2739 0.173256502718912 4092 2996599
SGTC_545 4218-0007 221 µM -0.946985480418765 0.184326695866672 no 2740 0.171823088835237 4036 2840508
SGTC_2653 dihydrofissinolide 100 µM -0.947178134615359 0.184278685208611 no 2741 0.171774007621666 4065 6857746
SGTC_1790 st045711 43.5 µM -0.950317801870326 0.183497357124156 no 2742 0.17097539805354 4024 585119
SGTC_2932 9016711 44.54 µM -0.953996934358155 0.182584411184584 no 2743 0.170042597085232 4063 7117328
SGTC_2976 9009005 19.48 µM -0.95447231727047 0.182466656178831 no 2744 0.169922307720137 4056 2993148
SGTC_2166 5933061 31.504 µM -0.95755053850184 0.181705312167311 no 2745 0.169144725261499 4131 2877375
SGTC_234 nsc-17383 10.7 µM -0.958173309275529 0.181551522822289 no 2746 0.168987686879874 4045 408974
SGTC_2408 sulbentine 18.36 µM -0.958805218644101 0.18139556005191 no 2747 0.168828439855252 4024 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2956 9076196 2.52 µM -0.961741795279176 0.180671879079482 no 2748 0.168089661015329 4067 16423868
SGTC_792 4534-1957 155 µM -0.962102587218544 0.180583091657666 no 2749 0.167999037315866 3984 1717904
SGTC_1552 6-methylflavone 10.6 µM -0.963459200878093 0.18024948704811 no 2750 0.167658564647368 3947 689013
SGTC_508 roscovitine 141 µM -0.963744060245583 0.18017948649987 no 2751 0.167587129284398 4107 160355 A CDKinase inhibitor.
SGTC_693 4161-2696 114 µM -0.964742095371898 0.179934366771548 no 2752 0.167337002586837 4079 805759
SGTC_3132 9126706 49.47 µM -0.96762218795665 0.179228184249626 no 2753 0.166616545971854 4140 850858
SGTC_3264 9137442 49.47 µM -0.968280733937196 0.179066957655271 no 2754 0.166452091988402 4056 17015726
SGTC_2761 levamisole 97.89 µM -0.969346229566649 0.178806294119681 no 2755 0.166186235397265 4010 26879 An alkaline phosphatase inhibitor.
SGTC_3341 9147222 25.867 µM -0.969653647553873 0.178731131606776 no 2756 0.166109581170724 4066 1939759
SGTC_678 1218-2179 85.9 µM -0.972154366884086 0.178120454612341 no 2757 0.165486879305166 4037 6820081 YOR116C RPO31
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.973541752657352 0.177782222244749 no 2758 0.165142059731464 4061 16486 A toxic proline analog.
SGTC_1056 3448-1962 115 µM -0.974148303280421 0.177634477944934 no 2759 0.16499145441913 4067 715507
SGTC_1608 st001473 40.5 µM -0.976155187321899 0.177146191293809 no 2760 0.164493783245279 4036 7292267
SGTC_2419 paclitaxel 166.5 µM -0.977199452628257 0.176892451107948 no 2761 0.164235209474857 3988 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_460 trequinsin 123 µM -0.978727123079608 0.176521665048697 no 2762 0.16385741337201 4114 5537 A vasodilator.
SGTC_2872 9044037 25.97 µM -0.980014502599123 0.176209582777616 no 2763 0.163539479974027 4057 6465195
SGTC_3208 9114115 49.47 µM -0.980058265009117 0.176198980180028 no 2764 0.163528679381032 4086 650895
SGTC_1516 st013856 110 µM -0.981630824991363 0.175818254030397 no 2765 0.163140877891214 4113 5281404 A mutagen and neurotoxin.
SGTC_1951 sophoraflavanone G 9.2 µM -0.984801514435247 0.175052197070945 no 2766 0.162360788304331 4046 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2036 5160441 105 µM -0.985207196394548 0.174954334981423 no 2767 0.162261153237659 4045 134534 YIL048W NEO1
SGTC_1349 flufenamic acid 69 µM -0.98593963746877 0.174777737187035 no 2768 0.16208136730521 3992 3371 A non-steroidal anti-inflammatory.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.986178727777414 0.174720114978116 no 2769 0.162022707986345 4076 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1393 3470-5649 58.2 µM -0.986761424740212 0.174579732010147 no 2770 0.161879804837131 4045 4108395
SGTC_3042 9091578 49.47 µM -0.989456649960591 0.173931332356634 no 2771 0.161219884732331 4056 25236497
SGTC_2188 6126565 140.678 µM -0.990324267402232 0.173722932859589 no 2772 0.161007824406895 3991 874518
SGTC_577 r071-0003 38.6 µM -0.990884618331698 0.17358842245519 no 2773 0.160870961994424 4099 4568517 YMR134W ERG29
SGTC_2266 7929956 200 µM -0.993669377742066 0.172920933507754 no 2774 0.160191927856964 4044 2967153
SGTC_1779 st039427 55 µM -0.993922535423676 0.172860334439545 no 2775 0.160130291074691 4022 1124498
SGTC_643 k048-0106 28.4 µM -0.995017394166081 0.172598410869802 no 2776 0.15986390228891 4087 6763920
SGTC_965 1291-5240 308 µM -0.995075550219436 0.172584505251333 no 2777 0.159849760520763 4100 2834598
SGTC_2781 5567276 71.43 µM -0.995131479579264 0.17257113272854 no 2778 0.15983616098813 4134 2853274
SGTC_379 3970-0972 5.9 µM -0.995265262826051 0.172539148282346 no 2779 0.159803633923626 4077 2898042 YBL034C STU1
SGTC_1830 st055982 50.3 µM -0.997593944690447 0.171983020562239 no 2780 0.159238149273888 4016 455313 An antimicrobial agent.
SGTC_3101 9120531 49.47 µM -0.998129513348033 0.171855279954925 no 2781 0.159108280235535 4111 24824904
SGTC_1587 estradiol valerate 56.1 µM -0.998626066539288 0.17173689922472 no 2782 0.158987933989555 4142 13791 A steroid.
SGTC_480 am 92016 50 µM -0.999576057613102 0.171510561853798 no 2783 0.158757857322322 4062 2129 K+ channel blocker.
SGTC_1798 st045719 60.953 µM -0.999718499108673 0.171476641309082 no 2784 0.158723378493297 3969 3980186
SGTC_715 0868-0130 184 µM -0.999861174684856 0.17144266931943 no 2785 0.15868884792523 4139 2876258
SGTC_1300 1094-0077 113 µM -1.0028266782247 0.170737537515191 no 2786 0.157972247238484 4070 5532636
SGTC_3147 9097027 49.47 µM -1.00425216978223 0.170399248375407 no 2787 0.157628540851913 4102 25236841
SGTC_1316 1272-0050 65.9 µM -1.00458605782793 0.170320074153471 no 2788 0.15754810674247 4053 7340392
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.00460479894761 0.170315630806865 no 2789 0.157543592779376 4105 1377
SGTC_2996 9066192 71.4286 µM -1.00600228204449 0.169984509681124 no 2790 0.157207236157041 4137 6472854
SGTC_1270 0831-1170 17.3 µM -1.00665227716044 0.169830639849296 no 2791 0.157050951507808 4098 6764716
SGTC_3046 9092212 49.47 µM -1.0071697516106 0.169708204793629 no 2792 0.156926603179869 4151 25236637
SGTC_1689 st020265 53.493 µM -1.00765094099563 0.169594405636841 no 2793 0.156811032234328 4096 5758320 YPR016C TIF6
SGTC_113 0099-0221 2.5 µM -1.00795817664856 0.169521771379943 no 2794 0.156737270395801 4013 89219
SGTC_1771 st048882 4.1505 µM -1.00825954390103 0.169450543878913 no 2795 0.156664939645171 4118 4580403
SGTC_2894 9048625 32.47 µM -1.01004876742147 0.169028060310193 no 2796 0.156235963019614 4087 4092861
SGTC_1903 st060211 78.3 µM -1.01097409920241 0.168809830354823 no 2797 0.156014413275111 4128 688960
SGTC_2621 lithochol-11-enic acid 100 µM -1.01274170384191 0.168393462504069 no 2798 0.155591776187679 4031 6708711
SGTC_719 2810-4230 27.3 µM -1.01300811673969 0.168330764973026 no 2799 0.155528141989852 4095 721079
SGTC_1607 st000305 50.6 µM -1.01318333831791 0.168289536565609 no 2800 0.155486298705085 4121 5457690
SGTC_626 0214-0009 33 µM -1.01362526731525 0.168185582626374 no 2801 0.155380798113936 4171 3437874
SGTC_543 3844-1095 191 µM -1.01730608232905 0.167321358475768 no 2802 0.154503922024027 4109 4230703
SGTC_809 3998-0021 90 µM -1.01861557735576 0.167014591598582 no 2803 0.15419275301252 4057 715485
SGTC_1679 SEC14.276 6.7 µM -1.02001455532535 0.16668726311848 no 2804 0.153860778865643 4104 1005053 YMR079W SEC14
SGTC_1485 3909-9022 254 µM -1.02020184047482 0.166643474167296 no 2805 0.153816372473865 4140 714516
SGTC_2691 st077356 60.2 µM -1.02088479968894 0.16648385506837 no 2806 0.153654510772473 4163 2839272
SGTC_1298 1079-1278 263 µM -1.02478909793417 0.16557325037845 no 2807 0.152731355797822 4110 2840950
SGTC_174 3553-0389 74.3 µM -1.02536538912667 0.165439114552311 no 2808 0.152595406383179 4201 738071
SGTC_1938 st074717 56.4 µM -1.0262144341876 0.165241621464639 no 2809 0.152395259551187 4013 17250979
SGTC_716 1683-5115 658 µM -1.02827413905441 0.16476315579214 no 2810 0.151910446164421 4051 723597
SGTC_1699 st031318 29.054 µM -1.02844093173879 0.164724449476501 no 2811 0.151871231393428 4159 5340658
SGTC_624 k048-0052 28 µM -1.02884287086275 0.164631198711309 no 2812 0.151776758775905 4102 6835531
SGTC_463 ikarugamyin 104 µM -1.02886479692511 0.16462611280044 no 2813 0.15177160635155 4222 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2322 7413319 38.22 µM -1.03257612318587 0.163766710632969 no 2814 0.150901153370853 4161 1840400
SGTC_1311 1190-0148 100 µM -1.03261410516385 0.163757930530232 no 2815 0.150892262305182 4183 1961333
SGTC_1257 0669-0121 16 µM -1.03282072835646 0.163710171838906 no 2816 0.150843900727721 4149 4307855
SGTC_1946 st076057 65.1 µM -1.03377050790581 0.163490757000869 no 2817 0.15062173103834 4064 953009
SGTC_3080 9117754 49.47 µM -1.03462896122229 0.163292604436388 no 2818 0.150421111709848 4159 9550191
SGTC_37 0566-0070 1.56 µM -1.03504972410731 0.163195538811181 no 2819 0.150322845060904 4087 1626686
SGTC_433 pimozide 108 µM -1.03603808768649 0.16296768111225 no 2820 0.150092186966238 4032 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.0437886170067 0.161188045543753 no 2821 0.148291599609813 4137 66535 A nucleotide analog.
SGTC_1728 st035614 33.7865 µM -1.04440490846427 0.161047082184371 no 2822 0.148149046812252 4099 15945546
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.05375367918122 0.158918622605902 no 2823 0.145997852867411 4131 2724 A muscle relaxant with antifungal properties.
SGTC_3105 9121040 49.47 µM -1.05404953936191 0.158851565645028 no 2824 0.145930118469345 4021 41448907
SGTC_133 0724-0033 378.92 µM -1.05570586469214 0.158476500685943 no 2825 0.145551308466484 3982 280309
SGTC_1799 st045822 46.1415 µM -1.05908314729854 0.157713536373046 no 2826 0.144780957158619 4127 3674992
SGTC_768 0384-0033 77.3 µM -1.05936425897131 0.157650139194318 no 2827 0.144716960169133 4124 3965305 YMR134W ERG29
SGTC_311 1315-0136 58 µM -1.05946566386205 0.15762727415758 no 2828 0.144693879330919 4177 6759207
SGTC_56 0957-0365 83.25 µM -1.0650629725341 0.156368557922109 no 2829 0.143423716911629 4143 6752360
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.06616650856926 0.156121179429358 no 2830 0.143174189452308 4196 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3150 9097574 49.47 µM -1.06807939969556 0.155692979937503 no 2831 0.142742348720626 4200 17217476
SGTC_2839 9003951 25.97 µM -1.06819086628946 0.155668052113567 no 2832 0.142717211991825 4216 2990634
SGTC_3006 9075424 71.4286 µM -1.06820137380984 0.15566570240075 no 2833 0.14271484260495 4121 7465181
SGTC_3025 9087895 49.47 µM -1.069148121057 0.155454084883264 no 2834 0.142501465558206 4160 17173641
SGTC_1347 1493-0251 600 nM -1.06923859302735 0.155433872474222 no 2835 0.142481086367184 4213 3986378
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.06965843971011 0.155340096915947 no 2836 0.142386539939995 4206 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_316 k060-0003 58.6 µM -1.06994240328943 0.155276692926234 no 2837 0.142322617467331 4202 6152314
SGTC_2214 7179297 48.276 µM -1.07022761113433 0.155213028309838 no 2838 0.14225843444662 4197 769744
SGTC_391 gliotoxin 8.33 µM -1.07229323230192 0.154752450945081 no 2839 0.141794172786862 4247 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_591 4299-0174 154 µM -1.07380202110356 0.154416603299745 no 2840 0.141455711957832 4175 5509088
SGTC_2618 avocadyne 43.43 µM -1.07419538561742 0.154329121889821 no 2841 0.14136756004939 4076 3015189
SGTC_1321 1326-2144 215 µM -1.07594719691839 0.153939929800169 no 2842 0.140975436131529 4172 3513030
SGTC_2239 6685329 187.64 µM -1.07635052028226 0.153850417309252 no 2843 0.140885261159475 4226 805680
SGTC_186 3455-3465 67.277 µM -1.07779160206231 0.153530869026879 no 2844 0.140563384060682 4145 755278
SGTC_791 1348-1292 225 µM -1.07794449969615 0.153496991017737 no 2845 0.140529262470161 4152 5437054
SGTC_2876 9059903 25.97 µM -1.08155750404919 0.152697887125524 no 2846 0.139724598002669 4160 6916095
SGTC_2482 5981709 142.65 µM -1.08323610468787 0.15232756425841 no 2847 0.139351818970139 4120 877755
SGTC_1448 4255-0083 152 µM -1.08396671143601 0.152166568515632 no 2848 0.13918977935947 4238 5399660
SGTC_2340 7987427 183.45 µM -1.08529380248111 0.151874421220053 no 2849 0.138895774962095 4207 2239331
SGTC_877 0771-0151 33.1 µM -1.08633366881225 0.15164576445912 no 2850 0.138665698155078 4198 6166523
SGTC_1998 st075797 76.8 µM -1.08647453016274 0.151614807988355 no 2851 0.138634551694614 4168 24208315
SGTC_1422 4031-0024 15.5 µM -1.08944076110167 0.15096390821496 no 2852 0.137979782370603 4105 782427
SGTC_2383 9036125 200 µM -1.08983146936184 0.150878311328872 no 2853 0.137893694443683 4106 79580
SGTC_1654 st012436 41.8 µM -1.08984364776274 0.150875643787878 no 2854 0.13789101166661 4175 4323132
SGTC_2586 curcumin 80 µM -1.09001190342234 0.150838792501505 no 2855 0.137853950311147 4107 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_712 r015-0009 80.6 µM -1.09301967758807 0.150181041993516 no 2856 0.137192580085181 4220 6813872 YLR060W FRS1
SGTC_1344 1488-0097 29.1 µM -1.09311512181312 0.150160201261695 no 2857 0.137171628687844 4221 747966
SGTC_2139 5578692 56.4705 µM -1.09342661363091 0.150092198852334 no 2858 0.137103266904652 4137 650991 YMR113W FOL3
SGTC_2634 4'-methoxyflavone 100 µM -1.09372320706798 0.150027468022493 no 2859 0.137038196441743 4201 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_959 1222-0044 107 µM -1.09385436791403 0.149998848408523 no 2860 0.137009427427501 4187 6083612
SGTC_226 1,3-diallylurea 8.28947 mM -1.09573408971824 0.149589088499008 no 2861 0.136597579833806 4117 74537 YKL182W FAS1
SGTC_303 1348-1668 34.2 µM -1.0991497806672 0.148846416728621 no 2862 0.135851369697355 4199 5380509
SGTC_3226 9131256 49.47 µM -1.09918257589343 0.148839298043917 no 2863 0.135844218632431 4131 17178073
SGTC_1611 st001856 99.4 µM -1.09921556977766 0.148832136467171 no 2864 0.135837024509855 4171 647478
SGTC_1688 st021091 57.6 µM -1.10127848266062 0.148384822623631 no 2865 0.135387736545294 4211 3656366
SGTC_1333 1482-0047 286 µM -1.10216408117771 0.148193069105136 no 2866 0.135195172213471 4210 3811116
SGTC_3089 9117425 49.47 µM -1.10324625616055 0.147958977203457 no 2867 0.134960119382664 4194 9401657
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.10396374934758 0.147803908388379 no 2868 0.134804431551117 4217 7104
SGTC_585 0kpi-0023 191 µM -1.10705151063649 0.147137805605653 no 2869 0.134135829126491 4136 64601
SGTC_985 1493-0307 8.71 µM -1.10818039425104 0.146894782018319 no 2870 0.133891958125405 4216 3278274
SGTC_3107 9121808 49.47 µM -1.10846780823232 0.146832951190984 no 2871 0.13382991722008 4108 662681
SGTC_2395 5646831 180.19 µM -1.1088944887474 0.146741192418954 no 2872 0.133737850820714 4230 6808628
SGTC_3210 9128157 49.47 µM -1.10962649683399 0.146583861782743 no 2873 0.133580004230606 4213 17590849
SGTC_2641 levomentholum 100 µM -1.11076202780457 0.14634002599653 no 2874 0.133335397567121 4194 16666
SGTC_1282 0886-0010 32.4 µM -1.11090440191656 0.14630947282499 no 2875 0.133304750271142 4248 2836211 YNL267W PIK1
SGTC_2411 st077133 39.94 µM -1.11186874585711 0.146102639501921 no 2876 0.133097294237038 4251 1403142 YNL221C POP1
SGTC_2763 lisinopril 49.32 µM -1.11271565809888 0.145921155102129 no 2877 0.13291528424603 4083 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2478 5763493 32.33 µM -1.11336279080063 0.1457825835029 no 2878 0.132776324445008 4129 1365576 YLR208W SEC13
SGTC_1646 st011709 75.6 µM -1.11342741762884 0.145768749712261 no 2879 0.132762452523527 4160 5757843
SGTC_354 2783-3500 4.88 µM -1.11403449140525 0.145638844718603 no 2880 0.132632194995291 4209 6740761
SGTC_1028 k015-0029 4.8 µM -1.11422596279319 0.145597888766445 no 2881 0.132591129970828 4156 4588309
SGTC_470 aa-861 153 µM -1.11611032301046 0.145195235084952 no 2882 0.132187456970798 4172 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_162 k030-0015 37.8 µM -1.11846212398204 0.144693749892295 no 2883 0.131684837202739 4282 1809920 YMR134W ERG29
SGTC_2624 nerol 100 µM -1.11901417903909 0.144576201956081 no 2884 0.131567045041445 4126 637566 A natural product oil.
SGTC_3146 9095609 49.47 µM -1.11965617950591 0.144439583063236 no 2885 0.131430152687386 4260 17173999
SGTC_359 0081-0058 15.9 µM -1.12910156094471 0.142439643447782 no 2886 0.129427496461196 4322 3494159
SGTC_592 k241-0073 46.5 µM -1.13031172840005 0.142184766096313 no 2887 0.129172447137172 4248 4230158
SGTC_1653 st012112 65 µM -1.13443399734851 0.14131887881177 no 2888 0.128306272521669 4212 720429
SGTC_281 1672-3440 14.9 µM -1.13680055882973 0.140823398208615 no 2889 0.127810834847544 4274 6833000
SGTC_1791 st048313 56.1 µM -1.13783485459166 0.140607221059447 no 2890 0.12759472393763 4236 1204976
SGTC_2179 6298986 200 µM -1.13813969491392 0.140543549679808 no 2891 0.127531077582753 4212 738374
SGTC_389 tpck 16.7 µM -1.13871840836226 0.140422728830101 no 2892 0.127410311126692 4247 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2424 5537928 59.2 µM -1.13963296727324 0.140231935698913 no 2893 0.127219622334709 4248 5382802
SGTC_58 0957-0393 9 µM -1.14319833333814 0.139489819134951 no 2894 0.126478127055965 3961 6997992
SGTC_2947 9072639 7.68 µM -1.1455440529539 0.139003026476498 no 2895 0.125991928870344 4228 16488146
SGTC_850 0388-0143 75.9 µM -1.14571704864229 0.138967171600969 no 2896 0.125956123658705 4213 67273
SGTC_1277 0873-0036 22 µM -1.14826549766323 0.138439712734726 no 2897 0.125429488880464 4309 5965735
SGTC_2281 7943571 200 µM -1.15118356995802 0.137837429553108 no 2898 0.124828361515749 4344 1244024
SGTC_852 0418-0143 439 µM -1.15191408988849 0.13768693218476 no 2899 0.124678188865428 4243 5369229
SGTC_1350 1495-0454 146 µM -1.15296516874579 0.137470591989198 no 2900 0.124462340676601 4283 1069057
SGTC_1227 3909-8010 46.6 µM -1.15508622630141 0.137034728512858 no 2901 0.124027559020972 4225 15982272
SGTC_1348 1493-0373 93.8 µM -1.15586647865837 0.136874629572226 no 2902 0.123867887920637 4261 3010129
SGTC_3175 9106517 49.47 µM -1.1566756343058 0.136708735087532 no 2903 0.123702454074884 4261 41468073
SGTC_1384 3089-0840 101 µM -1.15809378540324 0.13641831502042 no 2904 0.123412882914834 4226 1069836
SGTC_1100 amiodarone 5.07 µM -1.15862912296276 0.136308794217617 no 2905 0.123303696315189 4333 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1248 0469-0687 58.6 µM -1.15885775854283 0.136262037671887 no 2906 0.123257084797588 4226 4017482
SGTC_332 4112-0506 40.9 µM -1.15938089576244 0.136155096093638 no 2907 0.123150480218855 4210 2790355
SGTC_1877 wortmannin 25 µM -1.16036388737267 0.135954304847047 no 2908 0.122950341627451 4254 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1591 genipin 88.4 µM -1.16054515783489 0.135917299701436 no 2909 0.122913459602631 4290 442424 A DNA cross-linking agent.
SGTC_1264 0783-0040 158 µM -1.16121961488741 0.135779674401215 no 2910 0.122776299960774 4154 2855798
SGTC_2018 5133068 143 µM -1.163361931744 0.135343160402645 no 2911 0.12234134400334 4206 785362
SGTC_282 k297-0036 65.7 µM -1.16388374931953 0.135236981787698 no 2912 0.122235563051073 4246 5061378
SGTC_3180 9109287 49.47 µM -1.16443645637403 0.135124580122804 no 2913 0.122123590336554 4297 18891271
SGTC_1010 4112-3296 15.2 µM -1.16479260485169 0.13505218568108 no 2914 0.122051476518136 4314 704384
SGTC_2187 6125751 200 µM -1.16654880739865 0.13469559070108 no 2915 0.121696313628411 4256 874498
SGTC_562 3772-2733 112 µM -1.17059830625199 0.133875808811658 no 2916 0.120880139234427 4242 2876874 YIL048W NEO1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.17068291785946 0.133858716661982 no 2917 0.120863126992353 4319 23847180
SGTC_570 0987-0065 62.6 µM -1.17311111567619 0.133368842412012 no 2918 0.120375624759061 4063 3104428
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.1756358257355 0.132860806684661 no 2919 0.119870216493018 4200 1241132 A phosphatase inhibitor.
SGTC_68 0986-0284 82.829 µM -1.1767982394277 0.132627348129354 no 2920 0.11963802274917 4305 423278 YIL048W NEO1
SGTC_1859 st055998 20 µM -1.17724100294468 0.132538498101014 no 2921 0.119549663606005 4234 676301
SGTC_3275 9138069 49.47 µM -1.1781881955323 0.132348561254774 no 2922 0.119360793769671 4342 17617007
SGTC_195 4234-0266 16.654 µM -1.18093971359844 0.131797874404856 no 2923 0.118813336675831 4281 2303354
SGTC_1991 st073000 8.92 µM -1.18216196107883 0.131553762460494 no 2924 0.118570721405055 4326 4301969 YIL048W NEO1
SGTC_832 4083-0019 164 µM -1.18351432091586 0.131284027862651 no 2925 0.118302687137554 4354 1990758
SGTC_1817 st052116 64.4 µM -1.18684096623168 0.130622138707721 no 2926 0.117645178242544 4299 4361398
SGTC_3342 9147791 14.508 µM -1.18787952422542 0.130415974434271 no 2927 0.117440438874521 4230 1838168
SGTC_130 0136-0219 337.655 µM -1.18894089479118 0.130205514282646 no 2928 0.117231463083755 4105 234244
SGTC_2106 5357045 167.29 µM -1.19136777478383 0.129725169366109 no 2929 0.116754618958327 4295 668842
SGTC_29 0299-0004 12.984 µM -1.19263388232185 0.129475060310807 no 2930 0.116506395086113 4180 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1423 4048-0112 5.59 µM -1.19518713543918 0.128971703047324 no 2931 0.11600696181983 4329 X1423
SGTC_3048 9093155 49.47 µM -1.19634536919843 0.128743812812894 no 2932 0.115780905419272 4260 25236002
SGTC_2875 9039966 71.43 µM -1.19843884433983 0.128332616743737 no 2933 0.115373108897631 4290 6463691
SGTC_894 0960-0238 55.9 µM -1.19947495955869 0.128129442816243 no 2934 0.11517165787424 4288 6741907 YDL195W SEC31
SGTC_686 1319-0111 510 µM -1.19964512457201 0.128096096185786 no 2935 0.115138596754791 4336 4562600
SGTC_3306 9127676 59.7925 µM -1.20096681100375 0.127837295256753 no 2936 0.114882037900257 4251 41905287
SGTC_2287 7945887 168.79 µM -1.20370564440402 0.127302158387895 no 2937 0.114351684940742 4299 1245853
SGTC_1235 benzylparaben 21.5 µM -1.20372809868292 0.127297777527093 no 2938 0.114347344067628 4308 7180
SGTC_1501 4491-0275 38.4 µM -1.20581458496928 0.12689115872057 no 2939 0.113944495276628 4271 5104718
SGTC_987 1497-1013 404 µM -1.20846710619836 0.12637553641001 no 2940 0.113433820489004 4302 1676435
SGTC_2764 methyldopa 94.69 µM -1.21177825267737 0.12573393535261 no 2941 0.112798637578168 4292 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3032 9089427 49.47 µM -1.21397541648326 0.12530944703099 no 2942 0.11237855593448 4295 17173707
SGTC_3285 9112818 20.8695 µM -1.21499797397002 0.125112232209397 no 2943 0.112183432056384 4267 17017947 YPR165W RHO1
SGTC_3246 9135460 32.98 µM -1.2160821397172 0.124903372213617 no 2944 0.111976816727703 4275 41446951
SGTC_152 4469-0003 551.229 µM -1.21632005764279 0.124857570933021 no 2945 0.111931511851215 4281 697280
SGTC_587 k089-0003 57 µM -1.21722953350641 0.124682597050808 no 2946 0.111758448193357 4210 9659696
SGTC_818 4072-2707 53.5 µM -1.21954065732678 0.124238731723007 no 2947 0.11131952710586 4205 882871
SGTC_3003 9075612 71.4286 µM -1.22042851081782 0.124068508303013 no 2948 0.111151237383499 4320 6501993
SGTC_3173 9105693 49.47 µM -1.22064412806931 0.124027193795538 no 2949 0.111110395346637 4300 17096658
SGTC_3186 9110464 49.47 µM -1.2217512164479 0.123815215766665 no 2950 0.110900860851549 4307 17018021
SGTC_2828 7998861 71.43 µM -1.22243861439635 0.123683725005385 no 2951 0.110770902131067 4288 2988188
SGTC_2146 5545642 200 µM -1.22291088647642 0.123593441856966 no 2952 0.110681678140225 4264 825326
SGTC_775 4577-0580 57.3 µM -1.22396185129893 0.123392697024503 no 2953 0.110483309500764 4354 2006902
SGTC_846 0335-0850 148 µM -1.22473861338853 0.123244474543454 no 2954 0.110336860266281 4279 6819598
SGTC_227 fluconazole 33.516 µM -1.22572557261094 0.123056322085748 no 2955 0.110150981741054 4303 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_381 3461-2219 42.7 µM -1.22821505015708 0.12258262651009 no 2956 0.109683125219317 4301 2883159
SGTC_2297 7971671 152.32 µM -1.22951767802314 0.122335274113427 no 2957 0.109438886972327 4320 909016
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.23155874215984 0.12194840698474 no 2958 0.109056980401665 4312 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2814 7977482 42.97 µM -1.23305016810084 0.1216662632106 no 2959 0.108778523769341 4323 6456762
SGTC_3343 9148379 18.9835 µM -1.2346133560567 0.121371036408735 no 2960 0.108487217936317 4335 1955036
SGTC_230 MPP+ 141.667 µM -1.23850317451286 0.120638584752108 no 2961 0.107764772862439 4277 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1832 st054113 55 µM -1.24036986240542 0.120288195232533 no 2962 0.107419311411592 4336 1251267
SGTC_398 bronopol 33.3 µM -1.2434800613492 0.119705984158185 no 2963 0.10684549193157 4241 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2453 5731132 22.18 µM -1.25113328475813 0.118281815169799 no 2964 0.105442926831409 4371 1362040
SGTC_2425 5628681 7.85 µM -1.25500011378386 0.117566819979517 no 2965 0.104739359330149 4402 5714958
SGTC_3176 9106582 49.47 µM -1.25513099008614 0.117542673972744 no 2966 0.104715606081245 4311 17018027
SGTC_2644 guaiazulene 100 µM -1.25894908429223 0.116839799870691 no 2967 0.104024361530363 4347 3515 A coloring agent.
SGTC_2030 5175110 200 µM -1.26318768837974 0.116063009457449 no 2968 0.103260868160658 4341 2831986
SGTC_2546 rhodinyl acetate 100 µM -1.26455187546564 0.115813782407435 no 2969 0.103016006821175 4280 6708682
SGTC_1114 scopoletin 1.73284 µM -1.27041969563999 0.114746108007475 no 2970 0.101967585589969 4365 5280460 A coumarin with genotoxic properties.
SGTC_2182 6325192 200 µM -1.27124865508363 0.1145958417652 no 2971 0.101820101107641 4346 736248
SGTC_3324 9138759 60.749 µM -1.27141219341482 0.114566213568426 no 2972 0.101791023500961 4372 45595710
SGTC_1066 ketoconazole 628 nM -1.27642700570238 0.113660326904333 no 2973 0.100902307419655 4411 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_128 0906-2981 13.371 µM -1.27760533735618 0.113448213392841 no 2974 0.100694308847211 4326 6740226
SGTC_406 estrone 100 µM -1.27821314959793 0.113338910493832 no 2975 0.100587140441685 4322 5870 A steroid.
SGTC_292 k038-0015 474 µM -1.27935791641583 0.113133251039283 no 2976 0.100385523105692 4341 46368540
SGTC_1706 st031321 9.9705 µM -1.28016495176572 0.112988425781189 no 2977 0.100243564672407 4359 6103185
SGTC_2306 7482397 179.52 µM -1.28100838620043 0.112837210041619 no 2978 0.100095360251027 4376 891448
SGTC_2134 5324836 1.464 µM -1.28188410843139 0.11268035850179 no 2979 0.0999416517131999 4316 699272
SGTC_701 4424-0219 185 µM -1.28577269025547 0.111985751246599 no 2980 0.0992612019498555 4376 2911779
SGTC_2479 5617353 43.85 µM -1.28599411728116 0.111946290645532 no 2981 0.0992225573717172 4367 2731746
SGTC_1116 jasmonic acid 1.58368 µM -1.28908482280821 0.111396532423931 no 2982 0.0986842996646631 4403 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2537 larixol 68.93 µM -1.29050957992266 0.111143755981191 no 2983 0.0984368939039326 4334 6708759
SGTC_1590 st077108 57.8 µM -1.2910181742729 0.111053622139547 no 2984 0.0983486877683305 4375 5489485
SGTC_3083 9117465 49.47 µM -1.29178052401121 0.110918615456379 no 2985 0.0982165809575405 4335 16420915
SGTC_848 0368-0089 85.6 µM -1.29218509635824 0.110847016360653 no 2986 0.0981465258448521 4349 762535
SGTC_1686 st019653 115.5 µM -1.29540650458061 0.110278089710272 no 2987 0.0975900176754323 4354 97252
SGTC_1211 1056-0033 32.3 µM -1.2978500937986 0.109847931061582 no 2988 0.0971694260333822 4412 6741922
SGTC_800 3448-7362 155 µM -1.29819793511386 0.109786796659991 no 2989 0.097109663753882 4437 15991913
SGTC_1884 5633444 25 µM -1.2984450515519 0.109743379869542 no 2990 0.0970672233108323 4328 5724239
SGTC_1692 fluoroquinolonic acid 71 µM -1.29960864641007 0.109539109286679 no 2991 0.0968675673606555 4372 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3255 9139072 49.47 µM -1.30029705219533 0.109418387384994 no 2992 0.0967495889976327 4357 17646060
SGTC_911 3456-4043 236 µM -1.30189710326543 0.10913816455959 no 2993 0.0964757814265361 4367 914281
SGTC_424 splitomicin 100 mM -1.30733842797869 0.108189065179619 no 2994 0.0955488993021271 4390 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.30816821617567 0.108044853614744 no 2995 0.0954081299718399 4379 688798
SGTC_528 3492-0019 172 µM -1.30832785028854 0.108017126169274 no 2996 0.0953810663783432 4375 2869262
SGTC_2490 carminic acid 95.39 µM -1.31197793011929 0.10738452752358 no 2997 0.094763790603766 4339 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_82 0054-0107 293.755 µM -1.31538326701427 0.106796757470503 no 2998 0.0941905631359764 4332 3104697
SGTC_1431 4049-0260 9.09 µM -1.31588463763952 0.106710416021886 no 2999 0.094106382853013 4390 3854841
SGTC_2714 st079313 56.9 µM -1.31806965785471 0.106334720062771 no 3000 0.0937401652983912 4369 2939799
SGTC_2457 5731572 11.68 µM -1.31819741273651 0.106312783274194 no 3001 0.0937187857047085 4425 2865357
SGTC_3058 9093861 49.47 µM -1.31932992181821 0.106118463051141 no 3002 0.093529419339736 4394 17217477
SGTC_2367 9070478 135.38 µM -1.32055590622411 0.105908393359869 no 3003 0.0933247416980195 4318 572802
SGTC_2977 9011197 71.43 µM -1.32097995772707 0.105835803081518 no 3004 0.0932540235362859 4427 2704722
SGTC_257 daunorubicin 18.5 µM -1.32281802700999 0.10552157320069 no 3005 0.0929479503953881 4409 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_35 0133-0054 64.071 µM -1.32585244244964 0.105004297503171 no 3006 0.0924442891410903 4350 99677
SGTC_2843 9000894 45.46 µM -1.32713204599413 0.104786715052828 no 3007 0.0922325031561676 4353 2242070
SGTC_1974 st069448 26.9 µM -1.32832775944883 0.104583692436615 no 3008 0.0920349265310494 4375 6323587 YNR016C ACC1
SGTC_845 0330-0138 4.51 µM -1.32852499227084 0.10455023127075 no 3009 0.0920023664178251 4331 9039800
SGTC_3165 9101544 49.47 µM -1.32892987041588 0.104481566728415 no 3010 0.0919355539756023 4385 5002184
SGTC_2683 piperine 63.03 µM -1.33519539459399 0.10342313933197 no 3011 0.0909062018937671 4404 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3125 9127534 49.47 µM -1.33554348800678 0.10336456537751 no 3012 0.0908492659655246 4288 1639235
SGTC_2749 bexarotene 57.39 µM -1.3365597986456 0.103193687786815 no 3013 0.0906831844322557 4409 82146 An retinoic acid receptor inhibitor.
SGTC_2770 toltrazuril 17.5 µM -1.33951625409134 0.102697770069217 no 3014 0.0902013332962714 4336 68591 Kills coccidiodes.
SGTC_2871 9038510 12.99 µM -1.34158539873992 0.102351722269295 no 3015 0.0898652315476151 4376 4945164
SGTC_2895 9054447 58.44 µM -1.34324584906248 0.102074639195147 no 3016 0.0895961899976528 4460 2697450
SGTC_317 4495-0002 170 µM -1.34414931930102 0.101924104553155 no 3017 0.0894500532129517 4422 15991618
SGTC_1183 1254-0324 198 µM -1.34728046696744 0.101403648518639 no 3018 0.0889449603021266 4465 5799357
SGTC_3214 9129694 49.47 µM -1.35145667973736 0.100712499541047 no 3019 0.088274593942197 4428 17158655
SGTC_2107 5363541 170.161 µM -1.35241213898628 0.100554858359764 no 3020 0.0881217541461008 4350 244052
SGTC_706 4262-0057 46.9 µM -1.35289433336171 0.100475369511045 no 3021 0.0880446949900369 4412 883298
SGTC_703 3875-0075 71.8 µM -1.35330965905422 0.100406940600035 no 3022 0.0879783623568939 4452 2850814
SGTC_1852 st056254 31.4 µM -1.35544569924103 0.100055544561116 no 3023 0.0876377989959061 4367 442583
SGTC_2019 4016004 108 µM -1.35580675554556 0.0999962366797549 no 3024 0.0875803306579693 4419 45595336
SGTC_1323 1348-1351 11.2 µM -1.35655394688844 0.0998735829725901 no 3025 0.0874614915891997 4392 6989654
SGTC_1412 3909-8563 178 µM -1.3573383539437 0.0997449384631832 no 3026 0.0873368629848341 4496 23767530
SGTC_213 1246-0773 967 nM -1.35793165343354 0.0996477164610857 no 3027 0.0872426861354678 4427 6251622
SGTC_2104 5389443 200 µM -1.35857341767029 0.0995426306800773 no 3028 0.087140901668375 4436 2244536
SGTC_2994 9053520 71.4286 µM -1.36205750322759 0.0989735416932067 no 3029 0.0865898692098275 4440 4647384
SGTC_315 k915-0449 187 µM -1.36216587255247 0.0989558789416964 no 3030 0.0865727717071562 4438 20970215 YNL149C PGA2
SGTC_110 0850-0284 111.64 µM -1.36324086816841 0.0987807939036058 no 3031 0.0864033055688912 4304 3906265
SGTC_83 0170-0301 39.027 µM -1.36352035142191 0.098735311488316 no 3032 0.0863592874870298 4423 3089716
SGTC_259 usnic acid 108.925 µM -1.36541380230601 0.0984275795495695 no 3033 0.0860615141147729 4456 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2616 abietic acid 100 µM -1.36800373921339 0.0980077898012291 no 3034 0.0856554528398631 4441 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1793 st048256 72.231 µM -1.36967955479965 0.0977368653403559 no 3035 0.0853934767905709 4369 672022
SGTC_1134 3477-0009 42.5 µM -1.37375176767981 0.0970808109066627 no 3036 0.0847593797622901 4466 3973534
SGTC_2693 st077581 40.7 µM -1.37577715401027 0.0967557168947772 no 3037 0.0844453183022605 4403 25238761
SGTC_2077 5212015 200 µM -1.37937601523721 0.0961800386350656 no 3038 0.0838894251650282 4325 780900
SGTC_831 k061-1017 217 µM -1.38246026802125 0.0956886847120674 no 3039 0.0834152109894091 4449 1240153
SGTC_1369 1866-0067 208 µM -1.38795586230308 0.0948177602323006 no 3040 0.0825752428669482 4448 3531355
SGTC_1091 telmisartan 47.6 µM -1.38889448905844 0.0946695954902254 no 3041 0.082432418285344 4446 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_499 genistein 192 µM -1.38985200423866 0.0945186250657279 no 3042 0.0822869113038808 4520 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2751 anetholtrithion 17.25 µM -1.39223026086238 0.0941444158802708 no 3043 0.0819263409990206 4393 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1143 3454-2408 5.08 µM -1.39382823006215 0.0938935964356614 no 3044 0.0816847405850745 4430 X1143
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.40103377611694 0.0927687282371613 no 3045 0.0806019865381615 4343 17037758
SGTC_3073 9114972 49.47 µM -1.40619035466579 0.0919698665661335 no 3046 0.0798338037631064 4441 41905075
SGTC_105 0111-0055 734.78 µM -1.40728216291441 0.0918013781188118 no 3047 0.0796718681819606 4454 5179370
SGTC_1439 4092-1168 46 µM -1.40993075654814 0.0913935959974058 no 3048 0.0792800649521023 4446 2886240
SGTC_132 0417-1715 25.805 µM -1.41122155635681 0.0911953495214769 no 3049 0.0790896479717537 4425 6769098
SGTC_999 SEC7.066 22.7 µM -1.41185054253606 0.0910988628013234 no 3050 0.0789969864078606 4392 740511 YDR170C SEC7
SGTC_1838 st055369 84.5 µM -1.41332777571323 0.0908725524203765 no 3051 0.0787796853765474 4428 676036
SGTC_258 haloperidol 50.781 µM -1.41570367222372 0.0905094432396623 no 3052 0.0784311413830804 4440 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1854 st056233 32.9 µM -1.41871435902986 0.090050867553499 no 3053 0.0779911546135557 4364 5393174
SGTC_2171 5739187 198.077 µM -1.42250697794326 0.0894756510435181 no 3054 0.0774395636260839 4405 2262761
SGTC_1274 0865-0114 173 µM -1.42604086715158 0.0889421390190863 no 3055 0.0769282729833708 4442 870624
SGTC_509 pifithrin 175 µM -1.4277831909635 0.0886799732619381 no 3056 0.0766771362227464 4521 4817 A p53 inhibitor.
SGTC_1634 st006576 41 µM -1.42923181362819 0.0884624389692882 no 3057 0.0764688083367945 4437 3915356
SGTC_1753 st043925 64 µM -1.42986271036583 0.088367823923536 no 3058 0.0763782131580074 4473 670181
SGTC_783 0848-0141 92.7 µM -1.43430561117454 0.0877036602975388 no 3059 0.0757425348777342 4384 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2073 5212005 126 µM -1.4427114115832 0.0864572876451892 no 3060 0.0745508916257329 4353 691789
SGTC_801 0866-0028 10.1 µM -1.44302739845122 0.0864106942039529 no 3061 0.0745063766321372 4495 6849771
SGTC_27 0485-0001 32.618 µM -1.45539609883492 0.08460160119494 no 3062 0.0727798179046497 4461 2054479
SGTC_215 1287-0124 461.5 µM -1.46538655232586 0.0831612195383869 no 3063 0.0714077421374093 4498 5560863
SGTC_873 0591-4978 488 µM -1.47003431991373 0.0824974424992817 no 3064 0.0707762295727289 4503 3305145
SGTC_641 4092-0595 30 µM -1.47018775584139 0.0824755975539977 no 3065 0.0707554549681593 4516 786260
SGTC_1808 st050063 61.5 µM -1.47147208210938 0.0822929164992656 no 3066 0.0705817460913426 4444 4011993
SGTC_1760 st045453 10.4495 µM -1.47222574074041 0.0821858589509536 no 3067 0.0704799642810979 4498 3323419 YIL048W NEO1
SGTC_1846 st056244 14.8 µM -1.47252364055721 0.0821435710880181 no 3068 0.0704397639552587 4498 5393182
SGTC_3230 9131665 49.47 µM -1.47306256718053 0.0820671103243212 no 3069 0.070367082872259 4495 15943720
SGTC_2305 7443522 69.23 µM -1.47571150105784 0.081692069437978 no 3070 0.0700106785673571 4379 5415886
SGTC_216 k038-0035 28.382 µM -1.47619954531837 0.0816231124218198 no 3071 0.0699451657882272 4411 4444231 YPR107C YTH1
SGTC_1491 4138-0063 26.5 µM -1.47919070907488 0.0812014417092337 no 3072 0.069544675999272 4492 23883227
SGTC_3215 9129942 49.47 µM -1.4799155026114 0.081099513844831 no 3073 0.069447898973078 4469 17682944
SGTC_1059 3448-6867 171 µM -1.48087815732362 0.0809642848357997 no 3074 0.0693195222720107 4460 3934407
SGTC_1548 st061468 90.8 µM -1.48101264146963 0.0809454067207354 no 3075 0.0693016024379365 4522 390799
SGTC_5 0352-0601 109.883 µM -1.48179434864714 0.0808357409214377 no 3076 0.0691975116419358 4392 762456
SGTC_149 3970-0822 46.1 µM -1.4826438483765 0.0807166917258107 no 3077 0.0690845303330084 4454 3114250 YBL034C STU1
SGTC_1569 carminic acid 40.6 µM -1.4836231518485 0.0805796161324771 no 3078 0.0689544619154047 4562 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2221 6807166 181.081 µM -1.48431150252855 0.0804833712221601 no 3079 0.0688631500815829 4463 674925
SGTC_1488 4013-0813 75.9 µM -1.49060156782724 0.0796079157652137 no 3080 0.06803306622754 4475 2910057
SGTC_2800 7887935 81.82 µM -1.49162021048094 0.07946682087199 no 3081 0.0678993684359647 4471 2961002
SGTC_1603 st002045 67.8 µM -1.50305135813492 0.0778964167958502 no 3082 0.0664129003655939 4482 5887985
SGTC_1087 pterostilbene 9.05 µM -1.50601422278778 0.0774932491356391 no 3083 0.0660317612894954 4505 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2261 9010538 184.68 µM -1.50664599367805 0.0774074871263717 no 3084 0.065950710733875 4476 6457250
SGTC_536 3852-0578 10.6 µM -1.50707193851143 0.0773497064123265 no 3085 0.0658961093437103 4526 2869208
SGTC_544 k015-0020 52.4 µM -1.50914839351037 0.0770684980183011 no 3086 0.0656304324326186 4529 3008304
SGTC_1037 k284-1091 78.7 µM -1.50916020043609 0.0770669012643574 no 3087 0.0656289241458666 4470 3334711
SGTC_476 mead acid 10 µM -1.51188199571104 0.0766994795823006 no 3088 0.0652819425163489 4573 5312531 An omega 9 fatty acid.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.51352712238924 0.0764780467774375 no 3089 0.0650729085538318 4518 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2245 6637752 200 µM -1.51456441447226 0.0763386782491714 no 3090 0.064941374858061 4517 681890
SGTC_411 enrofloxacin 100 µM -1.51974653621364 0.0756453114768891 no 3091 0.0642873453896558 4540 71188 A bacterial gyrase inhibitor.
SGTC_1251 0490-5699 265 µM -1.52134617842637 0.0754322516989299 no 3092 0.0640864938029982 4516 3883818
SGTC_146 3448-8650 53.125 µM -1.52585822881727 0.0748337464091432 no 3093 0.0635225877237119 4481 2891488 YIL048W NEO1
SGTC_736 0958-0254 92.6 µM -1.53058049631432 0.0742112438536497 no 3094 0.0629365525197907 4565 6812352
SGTC_2877 9040724 71.43 µM -1.53616738999252 0.0734798802819125 no 3095 0.0622486658374663 4481 6463895
SGTC_2917 7979103 53.79 µM -1.54185756433038 0.0727406753137105 no 3096 0.061554104986554 4511 2980565
SGTC_1880 MG-132 525 µM -1.54286184289419 0.0726108037116088 no 3097 0.0614321503050256 4474 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1040 k898-0338 155 µM -1.54322603205092 0.0725637512895053 no 3098 0.061387971613885 4491 20969351
SGTC_680 0417-1641 114 µM -1.54707785322218 0.0720675333648775 no 3099 0.0609222367975239 4531 2835990
SGTC_3250 9135583 49.47 µM -1.54722827627405 0.0720482077500743 no 3100 0.0609041049153397 4534 7699353
SGTC_1172 0370-0043 85 µM -1.5483276121984 0.0719070910702708 no 3101 0.0607717198515218 4537 376585
SGTC_2521 angolensin 13.4 µM -1.54962060485121 0.0717413869253015 no 3102 0.060616302223753 4547 821428 A flavenoid.
SGTC_3019 9081971 49.47 µM -1.55074306173927 0.0715977755193279 no 3103 0.0604816352467033 4513 16451803
SGTC_2284 7945075 39.21 µM -1.55309162638685 0.0712980049062942 no 3104 0.0602006231544454 4479 1245402
SGTC_1627 st003713 25.6 µM -1.55477764921474 0.0710833958698946 no 3105 0.0599995170034174 4517 16195070 YER133W GLC7
SGTC_2216 7189485 200 µM -1.5563109703796 0.0708886548238896 no 3106 0.0598170820091419 4544 731273
SGTC_1262 0737-0114 49.6 µM -1.55975567465619 0.0704526514604941 no 3107 0.0594088149185839 4535 765919
SGTC_1924 st058459 75.1 µM -1.5627714061442 0.0700726391687689 no 3108 0.0590531860133168 4492 688683
SGTC_3312 9133330 71.43 µM -1.56465065990697 0.0698366331134971 no 3109 0.0588324217115876 4536 17617324
SGTC_597 k018-0003 82.8 µM -1.56530798461576 0.0697542275671563 no 3110 0.0587553559210784 4570 6786234
SGTC_3021 9087658 49.47 µM -1.56656584581826 0.0695967444086987 no 3111 0.0586081031780683 4544 25237042
SGTC_1451 4152-0210 104 µM -1.56867538748686 0.0693332462946092 no 3112 0.0583617981985128 4555 659563
SGTC_2380 9035439 200 µM -1.57042580024687 0.0691151900925664 no 3113 0.058158042030882 4580 6462575
SGTC_2386 9075165 157.42 µM -1.57129466568285 0.069007148359771 no 3114 0.0580571098473433 4511 16452277
SGTC_2256 7954252 200 µM -1.57382230411198 0.0686935815404693 no 3115 0.0577642680614535 4540 2972920
SGTC_48 0382-0018 55 µM -1.57536809086388 0.0685023607296659 no 3116 0.0575857526599639 4553 762596
SGTC_746 1095-0025 46.6 µM -1.57929127917195 0.0680188882336082 no 3117 0.0571346306208885 4550 6749286
SGTC_688 0527-0193 473 µM -1.58145736794852 0.0677530823423629 no 3118 0.0568867496508513 4574 4007154
SGTC_713 1488-1073 324 µM -1.58416659123523 0.0674217573225534 no 3119 0.0565779068820666 4579 3312542
SGTC_714 4296-0578 26.1 µM -1.58568737363478 0.0672363224665906 no 3120 0.0564051223980737 4595 1589775
SGTC_108 0509-0257 621.132 µM -1.58639721023032 0.0671499044459541 no 3121 0.0563246164380595 4510 536624
SGTC_2224 6650123 117.647 µM -1.58848002078741 0.0668968314146193 no 3122 0.0560889176772338 4579 2908370
SGTC_1553 gossypol 38.6 µM -1.58933645570797 0.0667929841483462 no 3123 0.0559922262108233 4475 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2125 5246583 200 µM -1.58984037835511 0.0667319391745467 no 3124 0.0559353948333467 4543 835267
SGTC_3155 9099265 49.47 µM -1.59213012881704 0.0664551034169586 no 3125 0.0556777343184396 4511 25236499
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.59974059385966 0.0655413676500301 no 3126 0.0548280712168968 4564 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_742 0kpi-0133 140 µM -1.60300348958933 0.065152610965192 no 3127 0.0544669418347283 4575 2728852
SGTC_1038 k292-0204 154 µM -1.60388359414516 0.0650480581989121 no 3128 0.0543698568588117 4497 4454212
SGTC_172 1112-0046 2.638 µM -1.61050905866841 0.0642651556000579 no 3129 0.0536433847351089 4541 2802135 YIL048W NEO1
SGTC_301 4119-0100 24.5 µM -1.61092784865996 0.0642159161491045 no 3130 0.0535977246689181 4569 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2471 5466956 24.79 µM -1.61301331845096 0.0639711524319024 no 3131 0.0533708071488786 4556 724419
SGTC_3266 9136860 49.47 µM -1.62176054376658 0.0629524188507402 no 3132 0.0524273148539199 4308 4871271 YPR165W RHO1
SGTC_3015 9080845 49.47 µM -1.6289001044902 0.0621303243388579 no 3133 0.0516670839923025 4593 5296973
SGTC_1139 k015-0024 46.9 µM -1.63240268539282 0.0617300891019865 no 3134 0.0512973419034582 4584 2766652
SGTC_2170 morpholine 200 µM -1.63484870063992 0.0614517819069165 no 3135 0.0510403843318962 4596 121171 Reacts with secondary amines.
SGTC_2491 paeonol 100 µM -1.6393590711571 0.0609411635803045 no 3136 0.0505692501653946 4545 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1756 st041558 35.5 µM -1.63981630475952 0.0608895859603906 no 3137 0.0505216835092991 4635 3955792
SGTC_3209 9113616 49.47 µM -1.64154635077041 0.0606947392882058 no 3138 0.0503420268912991 4597 16649353
SGTC_1492 4158-0558 28.5 µM -1.64460733491631 0.0603511906466924 no 3139 0.0500254066324572 4580 3967268
SGTC_2222 6885208 172.143 µM -1.64746360838582 0.0600319920196276 no 3140 0.0497313951765003 4591 609514
SGTC_1673 st016611 27.3 µM -1.65027646430562 0.0597189389757206 no 3141 0.0494432018801701 4561 5226799
SGTC_3257 9139206 32.98 µM -1.65893610780359 0.0587632013757146 no 3142 0.0485643338503892 4556 4910041
SGTC_3233 9132340 49.47 µM -1.66303397576395 0.0583151370900667 no 3143 0.0481528173363173 4583 17682950
SGTC_3160 9100216 49.47 µM -1.66342615640867 0.0582723968164454 no 3144 0.0481135804644423 4568 17191039
SGTC_876 0720-0963 56.8 µM -1.66601305143798 0.0579910903589129 no 3145 0.0478554074687935 4583 765861
SGTC_616 4092-0450 108 µM -1.66641060832644 0.0579479536441728 no 3146 0.0478158296596142 4583 787165
SGTC_2794 7785382 27.27 µM -1.66985936557231 0.0575748055088886 no 3147 0.0474735957637115 4565 2205081
SGTC_188 3229-0966 278.469 µM -1.67101822092219 0.0574498449276678 no 3148 0.047359039428158 4624 5722370
SGTC_2260 7964312 200 µM -1.6723258402634 0.0573090992833078 no 3149 0.0472300434312924 4590 231951
SGTC_479 n-linoleoylglycine 10 µM -1.67715063209363 0.0567921290166441 no 3150 0.0467565149760905 4613 6433346 An anti-infammatory.
SGTC_675 1309-0189 238 µM -1.68078997239339 0.056404614104182 no 3151 0.0464018585380963 4584 4246530
SGTC_2690 usnic acid 100 µM -1.68690924394373 0.0557577389445811 no 3152 0.0458104021677941 4581 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2272 7805186 180 µM -1.69090023438973 0.0553390105348425 no 3153 0.0454279292688432 4585 2956062 YPR165W RHO1
SGTC_3102 9121669 49.47 µM -1.69265746631365 0.0551554337051138 no 3154 0.0452603428843634 4611 41905072
SGTC_1568 digitonin 820 nM -1.69491707013818 0.0549200818328855 no 3155 0.0450455769006682 4563 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1111 tnp00062 510.699 nM -1.69732322214878 0.0546703393312485 no 3156 0.0448177846075147 4579 676306
SGTC_1658 st012944 20 µM -1.69790050497375 0.0546105549898424 no 3157 0.0447632709763075 4431 24207260
SGTC_3178 9107506 49.47 µM -1.70292896649062 0.0540919832519738 no 3158 0.0442906812255414 4569 8897194
SGTC_944 3370-0224 231 µM -1.70545030390079 0.0538334355912481 no 3159 0.0440552366417238 4554 4580514
SGTC_896 0964-0007 44.5 µM -1.70645973716306 0.0537301991260101 no 3160 0.0439612582756393 4555 6756758
SGTC_2526 patulin 37.61 µM -1.70926854936845 0.05344376213436 no 3161 0.043700608121853 4579 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1796 st049173 110.4 µM -1.71558675370026 0.0528038667051211 no 3162 0.0431188523217736 4576 94134
SGTC_867 0518-0118 155 µM -1.71572025642783 0.0527904116715669 no 3163 0.0431066277268176 4573 6848158
SGTC_2780 5215298 71.43 µM -1.72096937568079 0.0522635333461127 no 3164 0.0426281905858889 4600 2834131
SGTC_1120 ficusin 1.78878 µM -1.72779262579168 0.0515849041192763 no 3165 0.0420127049731697 4587 6199 A DNA cross-linker.
SGTC_2916 7875993 68.79 µM -1.72927796990661 0.0514381069014127 no 3166 0.0418796787516336 4514 1299250
SGTC_2514 salinomycin 42.74 µM -1.73604629428763 0.0507733920635211 no 3167 0.0412778246347908 4613 23682228 A polyether potassium ionophore.
SGTC_2655 perillic acid 100 µM -1.7388908003135 0.0504960834316234 no 3168 0.0410269863686127 4649 5702197 An apoptosis inducer.
SGTC_2492 derrusnin 100 µM -1.74076476391718 0.0503140524755913 no 3169 0.040862410372074 4630 1715307 Part of coumarin class of compounds.
SGTC_2485 5633444 17.78 µM -1.74260729271703 0.0501355852535842 no 3170 0.040701117644365 4572 5724239
SGTC_1618 st003135 44.5 µM -1.75010278373661 0.0494147691125929 no 3171 0.040050289756113 4592 1270615
SGTC_2821 7996764 71.43 µM -1.75823671547031 0.0486419415398576 no 3172 0.0393536202505504 4571 2987135
SGTC_1044 1222-0021 1.78 µM -1.77264760007208 0.0472964730118737 no 3173 0.0381435594906516 4542 4306703
SGTC_2379 9035213 200 µM -1.77913817665943 0.046700303982871 no 3174 0.0376085555459839 4618 646551
SGTC_2091 4-phenylthiadiazole 200 µM -1.78021273750319 0.0466021882207869 no 3175 0.0375205758074123 4629 270010
SGTC_1546 5-methoxyflavanone 78.7 µM -1.78414063729847 0.0462449471168344 no 3176 0.0372004077133056 4643 147795
SGTC_2270 7924575 90.91 µM -1.78991778876105 0.0457235164951481 no 3177 0.0367335643333165 4589 1262135
SGTC_2816 7982706 58.44 µM -1.79087603322663 0.0456374865532967 no 3178 0.0366565952419516 4594 2981853
SGTC_319 1348-1596 45.5 µM -1.79281215724157 0.0454640609516758 no 3179 0.0365014824558827 4672 5380505
SGTC_3124 9127567 49.47 µM -1.7960336970163 0.0451766709641794 no 3180 0.0362445790090061 4588 17592030
SGTC_1942 st076330 65.2 µM -1.79687000638818 0.0451023042114963 no 3181 0.0361781296252951 4643 24208414
SGTC_3034 9090421 49.47 µM -1.79692859559119 0.0450970980055117 no 3182 0.0361734781318046 4582 17173761
SGTC_2160 5660466 132.927 µM -1.80337866302105 0.0445268992081924 no 3183 0.0356643831162567 4576 2859134
SGTC_2012 4023501 200 µM -1.80640352695511 0.0442615030967029 no 3184 0.0354276655364697 4605 3477460
SGTC_1318 1280-3875 124 µM -1.81268729175368 0.0437142524140193 no 3185 0.0349400328237538 4647 373245
SGTC_827 3253-0474 693 µM -1.81778669117252 0.0432741717930254 no 3186 0.0345483707792075 4641 5402065
SGTC_32 0928-0142 34.1 µM -1.81820245407611 0.0432384495595403 no 3187 0.0345165975367055 4647 2244242
SGTC_209 4077-0173 175.592 µM -1.82236804965956 0.0428818557849765 no 3188 0.0341995795597371 4616 15993494
SGTC_2833 9001315 45.46 µM -1.82342789937892 0.0427915081524809 no 3189 0.0341193039796955 4569 2989378
SGTC_1101 ebselen 5.29 µM -1.82546645419513 0.0426181627149369 no 3190 0.0339653344795306 4655 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_214 4373-3496 70 µM -1.82608352188301 0.0425658033792014 no 3191 0.0339188409537183 4678 3779166
SGTC_1123 mangostin 811.285 nM -1.82681198419232 0.0425040589655131 no 3192 0.0338640216873587 4627 5281650 An antioxidant.
SGTC_2898 9056270 58.44 µM -1.82731641078361 0.0424613462617645 no 3193 0.0338261045940175 4653 19154699
SGTC_1882 5615643 20 µM -1.83308822614264 0.0419750804212721 no 3194 0.0333947258781809 4633 2253075
SGTC_52 0329-0193 875 nM -1.83506540115789 0.0418095470317684 no 3195 0.0332479998171904 4650 3739292
SGTC_3064 1327-0027 10 µM -1.83535919433768 0.0417849952008209 no 3196 0.0332262428195565 4625 16000455 YPR107C YTH1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.83561114992464 0.0417639489726121 no 3197 0.0332075934676666 4654 5024745
SGTC_2227 7312221 64.1025 µM -1.84046197954438 0.0413604230201824 no 3198 0.0328502206239634 4718 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_754 3474-0146 171 µM -1.84132065268445 0.0412893228563925 no 3199 0.0327872914759536 4626 24762078
SGTC_1161 k007-0610 110 µM -1.84843117521439 0.0407043545366608 no 3200 0.0322699961333655 4585 5843850
SGTC_1810 st050138 53 µM -1.84935888819312 0.0406285318997595 no 3201 0.0322030038439665 4658 3444541
SGTC_2793 7325131 81.82 µM -1.8494439018976 0.0406215894072562 no 3202 0.0321968705547666 4591 4176441
SGTC_2735 sertaconazole 140 nM -1.85111696450798 0.0404851575614457 no 3203 0.0320763640138394 4737 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2271 7849410 118.62 µM -1.85819157359069 0.0399123572084796 no 3204 0.0315709071033457 4584 972430
SGTC_1011 4112-3381 17.4 µM -1.85861900741357 0.0398779618329234 no 3205 0.0315405804841031 4663 2877139
SGTC_229 benomyl 22.8748 µM -1.85966301361417 0.0397940524848891 no 3206 0.031466609002324 4669 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_812 4251-0442 148 µM -1.86043933353096 0.0397317508365494 no 3207 0.031411697049566 4665 5723007
SGTC_1881 5652484 16 µM -1.86085121977884 0.0396987281312376 no 3208 0.031382595009552 4623 2255129
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.86253518214192 0.0395639496348165 no 3209 0.0312638455590281 4620 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1280 0880-0253 10.1 µM -1.86514968608366 0.0393554314908878 no 3210 0.0310802128670747 4651 6836607
SGTC_70 0141-0289 43.283 µM -1.86838481965754 0.0390986541149027 no 3211 0.0308542257353215 4614 352408
SGTC_2180 6301957 200 µM -1.87664001989434 0.0384496028356059 no 3212 0.0302837242260539 4673 845462
SGTC_820 1582-0060 59.9 µM -1.87866767638508 0.0382915325087655 no 3213 0.0301449420146661 4670 3848840
SGTC_2849 9019321 12.99 µM -1.88317586978985 0.0379419848809467 no 3214 0.0298382690143118 4648 16489627
SGTC_1722 st034304 3.6505 µM -1.88393912606444 0.0378830634863638 no 3215 0.029786605027585 4594 4036148 YLR033W RSC58
SGTC_707 0865-0008 204 µM -1.88776380541425 0.037588931735899 no 3216 0.0295288331335559 4698 723043
SGTC_3103 9120822 49.47 µM -1.8904379292006 0.0373843915507508 no 3217 0.0293497073540484 4643 17141819
SGTC_2899 9053889 58.44 µM -1.89159850819079 0.0372959037472024 no 3218 0.0292722474102374 4659 6470052
SGTC_802 4112-3352 742 µM -1.89331671260706 0.0371652143032216 no 3219 0.0291578819672822 4679 704594
SGTC_566 0958-0068 16.5 µM -1.90136441516713 0.0365580652267541 no 3220 0.0286271485753034 4573 6815365
SGTC_1181 1222-0449 220 µM -1.9223258626576 0.0350146737239759 no 3221 0.0272823838482418 4683 658318
SGTC_698 k064-0052 127 µM -1.93299282812008 0.0342500361739801 no 3222 0.0266185406518799 4726 5088751
SGTC_1452 4194-0072 190 µM -1.94031142964728 0.0337333990490023 no 3223 0.0261709265811857 4700 1343545
SGTC_1496 4469-0713 57.4 µM -1.9523483263 0.0328976436873067 no 3224 0.0254484317727355 4700 746691
SGTC_2934 9036370 36.88 µM -1.9561438216426 0.032637678438267 no 3225 0.0252241070838091 4630 6462800
SGTC_1447 4239-0816 81.9 µM -1.960717191636 0.0323266871127094 no 3226 0.0249560112402459 4705 1341554
SGTC_1084 voriconazole 435 nM -1.96586035102288 0.0319798753859781 no 3227 0.024657372072004 4697 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2978 9011784 42.97 µM -1.96840639667743 0.0318093316766203 no 3228 0.0245106482441851 4656 2994934
SGTC_2143 5623677 140.463 µM -1.97822868833048 0.0311584234576572 no 3229 0.0239514568627798 4665 5375313
SGTC_1909 st060837 51.5 µM -1.98108689488494 0.0309710974215485 no 3230 0.0237907648445534 4635 678937
SGTC_2850 9015429 58.44 µM -1.98341335393264 0.0308193108728524 no 3231 0.0236606383492516 4673 6457570
SGTC_260 nsc-65238 3.989 µM -1.98993796672102 0.0303969040126161 no 3232 0.0232988846860259 4684 3246252
SGTC_3139 9095020 49.47 µM -2.00231081034313 0.0296090516537676 no 3233 0.0226256570347089 4603 25236292
SGTC_847 0342-0274 5.54 µM -2.00580055593837 0.0293899281326462 no 3234 0.0224387656675153 4684 18097
SGTC_1561 5-methoxyflavone 52.9 µM -2.00890487658975 0.0291961389508285 no 3235 0.0222736113328909 4671 94525
SGTC_1090 efavirenz 20.7 µM -2.0238460126903 0.0282782192803394 no 3236 0.0214929991077339 4711 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2497 7-hydroxyflavone 100 µM -2.024244064069 0.0282540970043232 no 3237 0.0214725229040152 4680 5281894
SGTC_1606 st000094 49.2 µM -2.02480932337659 0.0282198712084224 no 3238 0.0214434736757094 4708 1242210
SGTC_1077 5-fluorocytosine 377 nM -2.04008542679362 0.0273079098625909 no 3239 0.020670908974933 4719 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_31 0508-1974 57.237 µM -2.04018174901137 0.0273022384935094 no 3240 0.0206661134271327 4658 6810525
SGTC_104 0074-0074 590.992 µM -2.0414949991774 0.0272250134137439 no 3241 0.0206008252186196 4627 3943124
SGTC_704 1310-0270 142 µM -2.04584602492204 0.0269704542141705 no 3242 0.020385761082483 4672 5718033
SGTC_2372 9071633 200 µM -2.0519237941529 0.0266181994054061 no 3243 0.0200885345132388 4721 21321366
SGTC_2371 9071574 200 µM -2.05522935463363 0.0264282350124732 no 3244 0.0199284285475351 4714 45596039
SGTC_224 benfluorex 43.875 µM -2.06725388983576 0.0257467384646041 no 3245 0.0193551183268159 4711 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1651 st011928 86.1 µM -2.07039767572185 0.0255710082145434 no 3246 0.0192075596646024 4707 720198
SGTC_1657 st012939 43.4 µM -2.0731547991661 0.0254177191417231 no 3247 0.019078937737253 4709 24207257
SGTC_3049 9092223 49.47 µM -2.08876033738597 0.0245645282359869 no 3248 0.0183646511932103 4675 8623917
SGTC_1125 tnp00248 1.32998 µM -2.11522955305062 0.0231723761249041 no 3249 0.0172051936487233 4700 24207736
SGTC_2930 9013230 14.89 µM -2.11993621110882 0.0229319187748566 no 3250 0.0170057125587169 4671 2995857
SGTC_134 0269-0018 6.916 µM -2.12063071484278 0.0228966160208183 no 3251 0.0169764456321012 4686 4378915
SGTC_2678 equilin 100 µM -2.12455833525375 0.0226978292113841 no 3252 0.0168117417859914 4720 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1976 st070609 63.5 µM -2.12823911850039 0.0225128577811519 no 3253 0.0166586314932647 4692 682556
SGTC_3313 9133968 57.047 µM -2.14356003576033 0.0217565304719451 no 3254 0.0160340779162551 4717 1494643
SGTC_2076 5212012 200 µM -2.14645230454885 0.0216161870557636 no 3255 0.0159184550770165 4712 604802
SGTC_2103 5378138 10 µM -2.14649906631761 0.0216139243033391 no 3256 0.0159165915918211 4751 244142
SGTC_1875 nocodazole 6 µM -2.15371690811666 0.0212670521902357 no 3257 0.0156311896752948 4740 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2317 5986382 200 µM -2.15551925967059 0.0211811738293132 no 3258 0.0155606115733102 4712 877883
SGTC_1563 conessine 56.1 µM -2.15889657785333 0.0210210412718577 no 3259 0.0154290957153399 4743 441082 An anti-amoebic, histamine inhibitor.
SGTC_2722 naftopidil 47.16 µM -2.16171916971957 0.0208879975709099 no 3260 0.0153199145606174 4690 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_71 0417-1750 47.813 µM -2.1636452019925 0.0207976231781353 no 3261 0.0152457947930639 4675 6811472
SGTC_3309 9129340 25.759 µM -2.16971313129593 0.0205150619331451 no 3262 0.0150142923286669 4705 17158987
SGTC_2975 9084847 53.72 µM -2.22663140105484 0.0180193950020806 no 3263 0.0129859592688998 4698 27211724
SGTC_3168 9103419 49.47 µM -2.23055076629861 0.0178575056816094 no 3264 0.0128554505692396 4756 16649256
SGTC_762 1165-0429 115 µM -2.23841276147964 0.0175365037198992 no 3265 0.0125970752982654 4733 5967793
SGTC_2046 4110841 106 µM -2.24361492438816 0.0173268204481158 no 3266 0.0124285940862654 4738 44119630 YMR134W ERG29
SGTC_1969 st069479 40.1 µM -2.25176423144186 0.0170026527611899 no 3267 0.012168587584198 4730 3895485
SGTC_1187 1391-0724 117 µM -2.26477579557567 0.0164958215351575 no 3268 0.0117632207381341 4758 6997986
SGTC_1225 1216-0074 20.6 µM -2.27989488049624 0.0159231945556793 no 3269 0.0113069618873828 4736 4241466
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.28124642765795 0.0158728454453489 no 3270 0.0112669344243896 4705 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2219 9098279 200 µM -2.28764526129899 0.0156363191125654 no 3271 0.0110790939118899 4728 902349
SGTC_520 3584-0023 682 µM -2.28878733550319 0.0155944231142798 no 3272 0.0110458558338244 4701 1340790
SGTC_81 0411-0046 9.971 µM -2.28887806570297 0.0155910988900936 no 3273 0.0110432190124478 4752 12925265
SGTC_1842 st055362 61.2 µM -2.29071301593874 0.0155239993425674 no 3274 0.010990008664201 4737 676032
SGTC_1007 4101-0031 70 µM -2.29117836542504 0.0155070221253905 no 3275 0.010976549851202 4722 1146276
SGTC_2164 5685496 200 µM -2.29549379295313 0.0153503412816719 no 3276 0.0108524208615637 4719 759046
SGTC_63 0099-0242 26.702 µM -2.30156823881205 0.0151321001518835 no 3277 0.0106797665003436 4731 3898502 YLR359W ADE13
SGTC_2913 7966556 36.57 µM -2.3069040064996 0.014942602776292 no 3278 0.010530086067409 4658 2976516
SGTC_2887 9044784 58.44 µM -2.34575287321181 0.0136234188383568 no 3279 0.00949434646433091 4677 6465546
SGTC_521 r062-0005 13.8 µM -2.3462330343613 0.0136077639779884 no 3280 0.00948212319061427 4707 2832033
SGTC_2900 5328528 85.29 µM -2.35166801603364 0.0134316449902618 no 3281 0.00934472349431391 4720 795359
SGTC_397 arbidol 50 µM -2.35610992968622 0.0132891710336607 no 3282 0.00923372583465448 4749 131410 A RNA synthesis inhibitor.
SGTC_3190 9110366 49.47 µM -2.35899571186987 0.0131973110004335 no 3283 0.00916223375567523 4732 17123768
SGTC_1221 2958-7315 257 µM -2.36474254601283 0.0130160112793081 no 3284 0.00902130432487688 4756 4562705
SGTC_78 0336-0123 156.75 µM -2.37568924859906 0.0126766182202138 no 3285 0.00875810375100959 4680 6765896
SGTC_695 3505-6186 243 µM -2.38731457615226 0.0123245966707133 no 3286 0.00848598093328269 4736 1819379
SGTC_2948 9070189 9.45 µM -2.38822710290639 0.0122973268043824 no 3287 0.00846493822198592 4701 6473636 YDL196W YDL196W
SGTC_646 4092-0839 27.3 µM -2.38940584301402 0.0122621788308783 no 3288 0.00843782446843676 4747 877796
SGTC_1294 1000-1494 117 µM -2.40784528714041 0.0117235731089278 no 3289 0.00802348986922254 4764 712797 YDL207W GLE1
SGTC_3144 9087057 49.47 µM -2.41248065972615 0.0115914506033204 no 3290 0.00792218901408369 4698 17249618
SGTC_1151 3909-8316 15.3 µM -2.41328058946927 0.0115687814141648 no 3291 0.00790482171554201 4766 800431
SGTC_1734 st037168 69.4 µM -2.4160873225628 0.0114895457195146 no 3292 0.00784414923453947 4742 708907
SGTC_2468 5987765 72.9 µM -2.43020365053931 0.0110981411424069 no 3293 0.00754517054172863 4764 26772094
SGTC_2465 5809242 33.21 µM -2.43126114269758 0.0110692924716455 no 3294 0.00752318275393217 4785 2731748
SGTC_1453 4237-0541 195 µM -2.44166103714356 0.0107890378311935 no 3295 0.00730993315047111 4756 739892
SGTC_2564 betulinic acid 100 µM -2.44624735079789 0.0106674223937606 no 3296 0.00721759645508039 4710 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1944 st076371 56.9 µM -2.45098418733863 0.0105430705611844 no 3297 0.00712331058480151 4745 24208455
SGTC_1434 4073-0095 163 µM -2.452940486997 0.0104920832828138 no 3298 0.00708468894820451 4778 24133745
SGTC_350 k064-0020 19.8 µM -2.46657708594715 0.0101426031253727 no 3299 0.00682056816507601 4753 2790705
SGTC_640 3381-0960 37.1 µM -2.47774691602189 0.00986395128167552 no 3300 0.00661074455221237 4784 1745025
SGTC_3192 9110362 49.47 µM -2.47778215954978 0.00986308275473534 no 3301 0.00661009164168618 4745 16649480
SGTC_1883 5-benzylidenerhodanine 20 µM -2.48467245234009 0.00969455884777388 no 3302 0.00648353422989549 4758 1273210
SGTC_1572 epiandrosterone 68.9 µM -2.52713034078686 0.00871059098452216 no 3303 0.00574994073855642 4754 441302 A steroid.
SGTC_3108 9121785 49.47 µM -2.53965392950704 0.00843760145173284 no 3304 0.00554811023360207 4707 17140271
SGTC_534 k292-0788 63.4 µM -2.54061540269656 0.00841695703413455 no 3305 0.00553287841915076 4768 4146317
SGTC_1928 4'-methoxychalcone 40.3 µM -2.54144651287232 0.00839914746778466 no 3306 0.00551974178499331 4757 641818
SGTC_1329 1447-1697 50.6 µM -2.55056101301412 0.00820599625005241 no 3307 0.00537748486639948 4765 2840515
SGTC_1499 4480-0877 67.3 µM -2.59073295230852 0.0074004334230919 no 3308 0.00478858889045932 4782 2861909
SGTC_2078 5212016 200 µM -2.59094251643009 0.0073964206272051 no 3309 0.00478567388656313 4737 1899708
SGTC_261 5-fluorouridine 15.376 µM -2.59151107801429 0.00738554329841193 no 3310 0.00477777325246925 4780 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1967 st070177 51.4 µM -2.59546303522878 0.00731032595963155 no 3311 0.00472317816698942 4775 5729214
SGTC_150 3970-0969 77.2 µM -2.60722653568736 0.00709041399667847 no 3312 0.00456394744905768 4762 6615640
SGTC_1198 1612-1005 86.7 µM -2.60832677740066 0.00707014721160617 no 3313 0.00454930247237417 4776 6998509
SGTC_2608 thymoquinone 42.66 µM -2.61230693447494 0.00699725781788622 no 3314 0.00449667360263845 4732 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2940 9060638 45.86 µM -2.63919574334991 0.00652198329295633 no 3315 0.00415514909722583 4741 4027022
SGTC_2551 apiole 73.87 µM -2.65358157190714 0.00627961876141716 no 3316 0.00398212590542076 4754 10659 A possible DNA adduct former.
SGTC_1034 k072-0165 12.7 µM -2.65838616570348 0.00620046875843192 no 3317 0.00392579350224514 4778 5835461
SGTC_2458 5808907 16.39 µM -2.68627206275477 0.00575829204738207 no 3318 0.00361271143665092 4796 2731747
SGTC_1959 st077091 55.8 µM -2.69001521542844 0.00570112027938654 no 3319 0.00357243806547887 4775 821356 YKL052C ASK1
SGTC_2359 9039622 200 µM -2.69841403963283 0.00557466932406194 no 3320 0.00348353642173804 4757 6463596
SGTC_1922 5578187 25 µM -2.71286476928825 0.00536292362259329 no 3321 0.00333521608769917 4769 1350412
SGTC_907 3448-6986 75.5 µM -2.71298959607263 0.00536112612937475 no 3322 0.00333396000039797 4769 590582
SGTC_1268 0828-0275 2.46 µM -2.7258374236291 0.00517895924368589 no 3323 0.00320692907722782 4789 745337
SGTC_1149 3909-7961 23.3 µM -2.7670810101411 0.00463083038807049 no 3324 0.0028280349135907 4791 735261
SGTC_1477 0139-0234 16 µM -2.77822935644726 0.0044918460656813 no 3325 0.0027328011852432 4792 620880
SGTC_993 3909-8757 62.7 µM -2.79455608423906 0.00429502377497231 no 3326 0.00259855125950744 4763 4288324 YLR208W SEC13
SGTC_2217 6934799 96.0675 µM -2.79842928998321 0.00424947809425268 no 3327 0.0025675905843386 4787 675606
SGTC_656 4090-1979 187 µM -2.80526153090754 0.00417018844051483 no 3328 0.00251378840699471 4793 22330961
SGTC_2080 5212524 12.4 µM -2.81408170503688 0.00406978663973388 no 3329 0.00244583968005852 4763 260183
SGTC_998 3996-0085 177 µM -2.84292398271647 0.00375640139143771 no 3330 0.00223508654223334 4773 715391
SGTC_1973 st070275 50.2 µM -2.87234481240796 0.0034591949350894 no 3331 0.00203719068598382 4787 17118334
SGTC_2316 5844804 197.44 µM -2.87379310496759 0.00344512557503092 no 3332 0.00202787275993843 4775 776813
SGTC_2719 novobiocin 32.65 µM -2.88334023270368 0.00335365991648986 no 3333 0.00196741096166377 4785 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1147 3809-1045 12.3 µM -2.89862669339787 0.00321174788496304 no 3334 0.00187400424964987 4793 325925
SGTC_1008 4106-0037 6 µM -2.92482930434 0.00298101717032337 no 3335 0.00172322606972532 4795 2905394
SGTC_524 r073-0010 27.8 µM -2.93873618752173 0.00286472487925005 no 3336 0.00164776726862449 4767 2772106
SGTC_1508 1080-0625 72.9 µM -2.98328100350936 0.00251925643798007 no 3337 0.00142588018402212 4763 767111
SGTC_2810 7959871 45.46 µM -3.05181751503971 0.00206082875765958 no 3338 0.00113730169164793 4764 2974535
SGTC_181 1447-1644 8.07 µM -3.06142252303404 0.0020030191180399 no 3339 0.00110143997012405 4768 534600
SGTC_129 0088-0017 176.636 µM -3.06910563470286 0.0019578410118127 no 3340 0.0010735033021654 4767 182446
SGTC_143 4032-1194 15.74 µM -3.12292028193293 0.00166647369483937 no 3341 0.000895331208440638 4795 1806963
SGTC_351 caspofungin 25 nM -3.15365188659653 0.00151837109596293 no 3342 0.000806206488429395 4793 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2909 7941780 10.49 µM -3.16344084982129 0.00147378027073735 no 3343 0.000779580158997027 4793 1243215
SGTC_1828 st055811 49 µM -3.17181648894494 0.00143657962437403 no 3344 0.000757443503687957 4804 5877589
SGTC_1736 st036774 51 µM -3.23630494554666 0.0011776361559869 no 3345 0.00060543975109608 4789 1272247
SGTC_2925 9010536 32.5 µM -3.25309110440538 0.00111763840010784 no 3346 0.000570784452213568 4780 2994177
SGTC_2403 6032726 181.2 µM -3.32861838692711 0.000880817440638975 yes 3347 0.000436389512575963 4790 2881040
SGTC_2998 9066762 71.4286 µM -3.34232839251803 0.000843133870299914 yes 3348 0.000415393541227845 4787 4945196
SGTC_662 k832-1615 104 µM -3.34500175718026 0.000835960877560131 yes 3349 0.000411410245443799 4800 5878478
SGTC_996 3970-0799 1.8 µM -3.44768508712665 0.000599432844449291 yes 3350 0.000282706428834384 4732 6615648 YGL040C HEM2
SGTC_2974 9094440 9.66 µM -3.44846107115226 0.000597908420487947 yes 3351 0.000281895366450082 4795 25236134
SGTC_2510 benzyl isothiocyanate 8.31 µM -3.98252844498866 9.21363052800717e-05 yes 3352 3.40929804425452e-05 4805 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1512 0259-0544 12.2 µM -4.04373250652843 7.32495095858881e-05 yes 3353 2.63034681027722e-05 4806 18476
SGTC_910 3454-3003 490 µM -4.08062822244966 6.36932793672402e-05 yes 3354 2.24570722778152e-05 4788 820824
SGTC_2516 gossypol 71.55 µM -4.25117121492671 3.28905582989029e-05 yes 3355 1.0632775875525e-05 4807 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_523 1934-0222 13.7 µM -4.7347518345819 4.42360642333974e-06 yes 3356 1.09661645731994e-06 4808 1361595