SGTCid condition conc unit MRPL31|YKL138C.score MRPL31|YKL138C.strain.pval MRPL31|YKL138C.strain.significant MRPL31|YKL138C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_310 1273-0058 1.06 µM 14.7275730497745 6.90930628159719e-38 yes 1 2.1441585263888e-49 8 2734232
SGTC_236 1509-0011 5.31 µM 13.4331494187559 7.05967234632894e-32 yes 2 1.93306374548511e-41 130 3107280
SGTC_2598 perillyl alcohol 100 µM 10.6512387616792 8.47022686378137e-21 yes 3 8.60299967857703e-27 1 10819 An apoptosis inducer.
SGTC_3033 9090887 49.47 µM 9.99318773089535 1.52378984189257e-18 yes 4 8.16229211234721e-24 2 19325384
SGTC_173 1273-0061 2.693 µM 9.15219373993416 7.27369685107761e-16 yes 5 2.78944611849116e-20 48 2847414 YPL266W DIM1
SGTC_2183 6420625 130.508 µM 8.02366835342431 1.25662887313383e-12 yes 6 5.13165811788524e-16 6 2897619
SGTC_275 trichlorophene 5.69 µM 6.35160655358648 1.40182162747508e-08 yes 7 1.06538870836787e-10 106 62616
SGTC_944 3370-0224 231 µM 6.33930207057004 1.48996981326791e-08 yes 8 1.15404158966804e-10 4 4580514
SGTC_70 0141-0289 43.283 µM 6.20508929485474 2.87702827900896e-08 yes 9 2.7332927202205e-10 73 352408
SGTC_767 0929-0023 86 µM 6.06018354539121 5.76857262946452e-08 yes 10 6.79831525106421e-10 22 1204563
SGTC_10 0279-0212 42.575 µM 5.8348095917765 1.65104607245703e-07 yes 11 2.69260145079869e-09 32 39851 YBR002C RER2
SGTC_1742 st038235 28.8875 µM 5.79798635937672 1.9536665582463e-07 yes 12 3.35579547901622e-09 50 564103 YBR002C RER2
SGTC_1031 k035-0009 16 µM 5.76653557307894 2.25392093141646e-07 yes 13 4.04588180631822e-09 8 5180959
SGTC_19 0279-0214 38.434 µM 5.49160713663563 7.62776326593277e-07 yes 14 1.99146296163412e-08 14 3566274 YBR002C RER2
SGTC_1484 3473-2379 286 µM 5.40864638035457 1.09014824411881e-06 yes 15 3.1751436532416e-08 2 671917
SGTC_63 0099-0242 26.702 µM 5.39643119791955 1.14851828297428e-06 yes 16 3.39897310896759e-08 41 3898502 YLR359W ADE13
SGTC_1921 5740136 50 µM 5.07644924224402 4.33337877988652e-06 yes 17 1.92276732493184e-07 31 1774243
SGTC_3031 9088762 49.47 µM 5.01472887021276 5.55094768138561e-06 yes 18 2.65541508726106e-07 4 205253
SGTC_2016 5121758 140 µM 4.73187697002582 1.66709167139572e-05 yes 19 1.11226616663011e-06 23 2795203
SGTC_1188 1403-0014 4.57 µM 4.71256974528502 1.79328210047055e-05 yes 20 1.22306158960149e-06 34 9614867
SGTC_2170 morpholine 200 µM 4.67827719361665 2.04007801540637e-05 yes 21 1.44647645681592e-06 4 121171 Reacts with secondary amines.
SGTC_622 1348-1566 26.3 µM 4.67135437145537 2.09366388522705e-05 yes 22 1.49610101720425e-06 11 7340407
SGTC_1183 1254-0324 198 µM 4.61148915835278 2.61611503057292e-05 yes 23 1.99897256252755e-06 13 5799357
SGTC_2727 riluzole 51.77 µM 4.60115866743638 2.71793667237786e-05 yes 24 2.10073608715381e-06 7 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2250 alverine citrate 130 µM 4.57179135758763 3.02829587266777e-05 yes 25 2.41786155676918e-06 119 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1935 st074532 41.6 µM 4.32126796217123 7.42842353631089e-05 yes 26 7.75675683167368e-06 21 2829742
SGTC_942 3253-1115 227 µM 4.27891126293679 8.60716736613882e-05 yes 27 9.39048568480695e-06 22 46497897
SGTC_1426 4048-4480 71.7 µM 4.27545838746696 8.71063887580251e-05 yes 28 9.53722137681883e-06 11 14224343
SGTC_2171 5739187 198.077 µM 4.16194662777253 0.000128412664134858 yes 29 1.57773055984894e-05 14 2262761
SGTC_1172 0370-0043 85 µM 4.15120440384661 0.000133153667334789 yes 30 1.65365110391178e-05 18 376585
SGTC_1195 1502-0147 41.1 µM 4.12213743890232 0.000146817909257878 yes 31 1.87686560430502e-05 24 817940
SGTC_2232 chlorophetanol 41.5365 µM 4.00295657768046 0.000217775951133337 yes 32 3.12778934639466e-05 120 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2603 homopterocarpin 100 µM 3.9367120453343 0.000269956747730032 yes 33 4.1302814854337e-05 39 101795 A weak amylase inhibitor.
SGTC_283 0987-0079 11.7 µM 3.93368868667215 0.000272595963305245 yes 34 4.18260573056886e-05 25 411556
SGTC_3205 9113483 49.47 µM 3.91568709646089 0.000288814513162604 yes 35 4.5073551845254e-05 29 17018033
SGTC_168 3970-0862 530.542 µM 3.87296532648937 0.00033096910781464 yes 36 5.37595645315764e-05 125 3135186
SGTC_195 4234-0266 16.654 µM 3.77991385297319 0.000443325671430389 yes 37 7.8441314671488e-05 41 2303354
SGTC_2325 6158266 200 µM 3.77039202423821 0.000456627787742489 yes 38 8.14956557281442e-05 29 3623240
SGTC_1049 3226-0134 66 µM 3.70322455421907 0.000561492853185984 yes 39 0.000106438147421549 36 5702385
SGTC_953 1188-0045 9.7 µM 3.6854205337981 0.000592804239672595 yes 40 0.000114162658703953 31 6144426
SGTC_1068 loratadine 26.9 µM 3.66033234574993 0.000639669986835205 yes 41 0.000125944161502399 31 3957 A H1 histamine antagonist.
SGTC_2611 pyromycin 23.93 µM 3.63992565838354 0.000680287812437198 yes 42 0.000136358383314712 40 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2943 9068529 45.32 µM 3.63142915415244 0.00069789048498901 yes 43 0.000140928017741617 27 3270634
SGTC_1417 3966-0327 90.4 µM 3.62803091671947 0.000705047648917365 yes 44 0.000142795534168199 24 651118
SGTC_1036 k216-0215 33.5 µM 3.58685339042632 0.000797320060219086 yes 45 0.000167346187551349 65 622330
SGTC_1240 0356-0016 42.1 µM 3.5103839253137 0.000998748055498882 yes 46 0.000223730059806023 47 4305613
SGTC_68 0986-0284 82.829 µM 3.46628875245641 0.00113515658653236 no 47 0.000263848112610715 93 423278 YIL048W NEO1
SGTC_1596 piperlongumine 63 µM 3.45638827112395 0.00116804107456403 no 48 0.000273733056906779 31 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1623 st003709 20.3 µM 3.40750295807773 0.00134357085135126 no 49 0.000327800989550383 101 16192618
SGTC_127 0180-0333 59.125 µM 3.40410043439708 0.00135664296371506 no 50 0.000331911703307747 71 771601
SGTC_2688 kanamycin b 96.69 µM 3.37465408809001 0.00147472172559548 no 51 0.000369542634158173 463 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2825 7998094 58.44 µM 3.36373687161394 0.0015208309574899 no 52 0.000384474089682438 50 2987815
SGTC_1846 st056244 14.8 µM 3.34919325819122 0.00158429906979051 no 53 0.000405236212524436 57 5393182
SGTC_1263 0774-1208 64.8 µM 3.34682553831641 0.00159485734328316 no 54 0.0004087131889713 75 906585
SGTC_979 1426-2828 121 µM 3.34212045693976 0.00161602907123909 no 55 0.000415704858644294 40 747872
SGTC_1516 st013856 110 µM 3.33569285111765 0.0016453656790243 no 56 0.000425435575001076 26 5281404 A mutagen and neurotoxin.
SGTC_2323 6148992 148.28 µM 3.30447166929172 0.00179488425287426 no 57 0.000475777963532823 56 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_211 3455-0679 143.504 µM 3.29574741935814 0.00183881944257906 no 58 0.000490801124985844 42 748649
SGTC_1458 k015-0034 6.33 µM 3.28968555203228 0.00186992025756078 no 59 0.000501497006683458 30 3598957
SGTC_314 1671-0008 2.74 µM 3.26209166260845 0.0020176223801971 no 60 0.000552966883504645 89 3913060
SGTC_653 0203-0016 55.2 µM 3.25939210854971 0.00203262668945976 no 61 0.000558256191610205 45 295302
SGTC_386 1509-0011 3.07 µM 3.25800076344602 0.00204039936788263 no 62 0.000561000522448207 179 3107280
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 3.24196347815958 0.00213195855481377 no 63 0.000593546170712868 56 6708561
SGTC_1703 st026983 48.3 µM 3.240782403984 0.00213884659297888 no 64 0.000596010679147087 31 1104023
SGTC_1318 1280-3875 124 µM 3.2334112454585 0.00218229319239094 no 65 0.000611606690002097 58 373245
SGTC_134 0269-0018 6.916 µM 3.22920937602321 0.00220741608383932 no 66 0.000620664886689278 176 4378915
SGTC_1247 0448-0043 5.84 µM 3.20884036159702 0.00233295684854833 no 67 0.000666357327527667 90 3089013 YGL099W LSG1
SGTC_2556 citropten 84.59 µM 3.19980409709396 0.00239069245665059 no 68 0.000687605134144648 66 2775 A potential DNA crosslinker.
SGTC_1174 0739-0097 51.1 µM 3.19144944644463 0.00244522020457203 no 69 0.000707804407936162 65 728447
SGTC_1922 5578187 25 µM 3.18166962100045 0.00251047718494457 no 70 0.000732143749393968 74 1350412
SGTC_1351 1496-0003 46.5 µM 3.14374512233061 0.00277868779715517 no 71 0.00083400325895687 46 3891978
SGTC_2384 9036245 200 µM 3.13824477366813 0.00281966448110916 no 72 0.0008498143992519 61 6462766
SGTC_2587 piperic acid 92.2 µM 3.13530691669684 0.00284177364779199 no 73 0.000858371992323573 49 5370536
SGTC_549 1661-1316 519 µM 3.10170038489297 0.00310603977175601 no 74 0.000962062980766294 54 2857282
SGTC_538 2922-0838 53.3 µM 3.09037110497696 0.00319999361980153 no 75 0.000999532752121779 72 777039
SGTC_2326 6164455 177.58 µM 3.08812577821866 0.00321891497439267 no 76 0.0010071160003456 56 2888790
SGTC_596 1155-0152 116 µM 3.08725012677017 0.00322632132424438 no 77 0.00101008766241424 86 280313
SGTC_838 0109-0203 71.4 µM 3.08194473697867 0.00327152360569968 no 78 0.00102826506704673 49 759422
SGTC_2267 7931562 200 µM 3.04745880099736 0.00357948957497753 no 79 0.00115392579976964 54 934880
SGTC_1614 st002383 48.6 µM 3.02106136445717 0.0038325456849999 no 80 0.00125945152695565 54 1947235
SGTC_1092 toremifene 6.32 µM 3.00596194390161 0.00398439784711965 no 81 0.0013237106455522 72 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_849 0386-0493 241 µM 2.99692075616786 0.00407788158141057 no 82 0.00136360797881186 52 726119
SGTC_3298 9116858 71.43 µM 2.99375419225069 0.00411108436798252 no 83 0.00137783927998244 45 2506942
SGTC_28 pentachloropyridine N-oxide 1.606 µM 2.9355185471253 0.00476639725543687 no 84 0.00166495352032858 136 140250 A respiratory chain inhibitor.
SGTC_1319 1306-0155 43.7 µM 2.93271723251254 0.00480014708380897 no 85 0.00168004883108428 90 3122360
SGTC_1374 2889-5571 141 µM 2.92598454638548 0.00488213443691191 no 86 0.00171683996679819 101 2853281
SGTC_2589 lobaric acid 100 µM 2.91294750899177 0.0050444488579393 no 87 0.00179017389848389 80 73157 A novel microtubule depolymerizer.
SGTC_2418 pentamidine 31.67 µM 2.91172868340653 0.00505986646167856 no 88 0.00179717346608341 98 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1032 k061-1018 98.7 µM 2.90532132938575 0.00514160874823501 no 89 0.00183438121507932 78 4005393
SGTC_2505 galangin 7.89 µM 2.88197870702464 0.00544943381713594 no 90 0.00197593218909003 38 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1066 ketoconazole 628 nM 2.86166050389728 0.00573059545605201 no 91 0.00210714029665257 70 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2018 5133068 143 µM 2.84573772160608 0.00595985641410355 no 92 0.00221543365518617 83 785362
SGTC_1281 0884-0031 11.8 µM 2.84071243102224 0.0060338815302733 no 93 0.00225064411042384 88 1548255
SGTC_748 act1.228 77.9 µM 2.83031242627247 0.00618967229265319 no 94 0.00232512848523369 149 4421505 YNR035C ARC35
SGTC_2944 9067346 25.62 µM 2.81382826818445 0.00644390745353168 no 95 0.00244776868605235 94 6473075
SGTC_2163 5671233 125 µM 2.8090879038517 0.00651870846658579 no 96 0.00248410395702625 90 701023
SGTC_2510 benzyl isothiocyanate 8.31 µM 2.80776712030545 0.00653968622683462 no 97 0.00249431438815305 69 2346 DNA damaging agent; causes G2/M arrest.
SGTC_279 1273-0055 2.93 µM 2.79463235960966 0.00675157425258449 no 98 0.00259793830641961 103 2847562
SGTC_1622 st003707 19.4 µM 2.79340197843021 0.00677172994896991 no 99 0.00260784167765589 126 10140899
SGTC_581 0958-0271 211 µM 2.79008280447601 0.00682636894844095 no 100 0.00263472814311691 135 4591145
SGTC_830 4076-0286 57.8 µM 2.78551945724345 0.00690212468228546 no 101 0.00267210162623296 187 6866659
SGTC_2748 diazoxide 86.69 µM 2.77700471705084 0.007045464159857 no 102 0.00274311913831236 40 3019 A potassium channel activatior.
SGTC_1730 st033808 45.1 µM 2.76108207540779 0.00732057383531683 no 103 0.00288050982743618 125 1045166
SGTC_1176 0848-0131 83.3 µM 2.75541645734473 0.0074207238361649 no 104 0.00293087359739156 89 6769040
SGTC_2295 7971645 200 µM 2.74961290548994 0.00752456190094149 no 105 0.00298328517732651 90 2978226 YKL099C UTP11
SGTC_1998 st075797 76.8 µM 2.74126511983808 0.00767616581423587 no 106 0.00306015507511276 75 24208315
SGTC_1680 diphenhydramine 100 µM 2.7308509204181 0.00786906290376684 no 107 0.00315855199628132 98 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2526 patulin 37.61 µM 2.72165607081242 0.00804290567126344 no 108 0.0032477852568096 198 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_625 k213-0058 121 µM 2.71475700003906 0.00817555121383904 no 109 0.00331622082985285 245 3655420
SGTC_832 4083-0019 164 µM 2.71138804082844 0.0082410204209101 no 110 0.00335010819923531 235 1990758
SGTC_717 1532-0246 73.2 µM 2.70280819826815 0.00840983705435264 no 111 0.00343782045232282 109 9561992
SGTC_2979 9012552 45.46 µM 2.70166377525416 0.00843258259474726 no 112 0.00344967460232828 39 17100905
SGTC_2313 7726885 200 µM 2.69037388246772 0.00865988023383687 no 113 0.00356860032937846 104 726423
SGTC_119 0121-0043 24.815 µM 2.68788075797843 0.00871079222016405 no 114 0.00359535347945473 254 1092378
SGTC_3030 9087619 49.47 µM 2.67691792790848 0.00893779076002049 no 115 0.00371514167161121 81 25236973
SGTC_2680 butyl paraben 22.24 µM 2.67228166613451 0.00903533892573827 no 116 0.00376686912268829 60 7184 An antifungal and steroid mimetic.
SGTC_1615 st002656 86.5 µM 2.6576678148237 0.00934894587981104 no 117 0.00393417030238685 76 1584458
SGTC_1411 3909-8223 150 µM 2.61647103167265 0.0102848132366638 no 118 0.00444219513268081 65 X1411
SGTC_1259 0671-0132 43 µM 2.61094043827901 0.0104164741655012 no 119 0.00451468091651061 114 X1259
SGTC_2420 aureobasidin a 50 nM 2.60791347204108 0.0104891541142089 no 120 0.00455479892498773 142 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3127 9126946 49.47 µM 2.59205998816532 0.0108770713215449 no 121 0.0047701567278222 89 27243249
SGTC_3077 9117319 49.47 µM 2.58477986386355 0.0110593520145949 no 122 0.00487205942541952 75 17154678
SGTC_1266 0828-0227 32.9 µM 2.5816621418635 0.0111382229258285 no 123 0.00491628955738697 105 3913820
SGTC_1514 1189-1591 158 µM 2.5722941972559 0.0113781593949701 no 124 0.00505135005951408 140 767698 YMR146C TIF34
SGTC_2426 5582046 32.21 µM 2.5722830196027 0.0113784483442444 no 125 0.00505151316529249 112 2251934
SGTC_3206 9114350 49.47 µM 2.54186052898146 0.0121888971752503 no 126 0.00551320813934584 95 17087243
SGTC_225 nsc-122657 1.016 µM 2.53535723474574 0.0123684928966341 no 127 0.00561663530656006 48 275685
SGTC_819 1013-0258 27.7 µM 2.53291963276231 0.0124363981843064 no 128 0.0056558442178495 127 5753198
SGTC_629 3448-6466 76.7 µM 2.53200944021891 0.0124618364538659 no 129 0.00567054689362331 113 573744
SGTC_1103 duloxetine 36.1 µM 2.53085319679024 0.0124942163757519 no 130 0.00568927304681907 140 60835 A selective serotonin reuptake inhibitor.
SGTC_485 niflumic acid 177 µM 2.52803837941829 0.0125733483909946 no 131 0.00573509062924103 82 4488 A COX2 inhibitor.
SGTC_1027 k015-0025 8.67 µM 2.50531467444755 0.0132282119635597 no 132 0.00611712469269036 122 3598955
SGTC_623 k072-0108 16.9 µM 2.50253409324581 0.0133103330295972 no 133 0.00616538742884027 119 5382803
SGTC_1002 4049-0206 172 µM 2.4973541426768 0.013464491226145 no 134 0.00625619637729595 159 4662749
SGTC_1308 1187-1617 41.4 µM 2.49520894730968 0.0135287833885662 no 135 0.00629414896168664 148 2882570
SGTC_1116 jasmonic acid 1.58368 µM 2.46175142096946 0.0145663387080307 no 136 0.00691302274330031 121 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_462 ag-879 158 µM 2.44883386451448 0.0149848718241321 no 137 0.00716597685032715 146 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1468 k284-1086 134 µM 2.44314532946597 0.0151724358297819 no 138 0.0072799364121005 177 15996457
SGTC_1885 st057546 99.9 µM 2.43428287358353 0.015468669504614 no 139 0.00746066449834828 132 702008
SGTC_365 0121-0052 13.6 µM 2.43408032890726 0.0154754973262933 no 140 0.00746484069912052 214 3101739
SGTC_2601 securinine 100 µM 2.42908936022502 0.0156445630450967 no 141 0.00756840052070415 139 442872 A GABA receptor antagonist.
SGTC_2917 7979103 53.79 µM 2.42354302867503 0.01583429799561 no 142 0.00768496616668786 153 2980565
SGTC_2528 xanthyletin 44.79 µM 2.42324568895376 0.0158445252092045 no 143 0.00769125966258839 114 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_665 3914-0008 307 µM 2.42199906758102 0.0158874653308922 no 144 0.00771769507412127 138 1069549
SGTC_874 0599-0792 117 µM 2.41979451943363 0.0159636457015521 no 145 0.0077646397431624 142 765305
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.41912213327304 0.0159869429096471 no 146 0.0077790077657115 127 16623 A steroid.
SGTC_1762 st045503 25.4615 µM 2.41344640208743 0.0161847627052571 no 147 0.00790122594561088 137 4645554
SGTC_782 0083-0095 30.5 µM 2.40828759158765 0.0163663816019175 no 148 0.00801377489958642 154 3591729 An indicator and reagent.
SGTC_778 3456-2434 196 µM 2.40590418136815 0.0164508786138781 no 149 0.00806624769772406 208 5539063
SGTC_2032 5185112 25.99 µM 2.40401449145675 0.0165181373656321 no 150 0.00810806522231372 99 5718189
SGTC_1883 5-benzylidenerhodanine 20 µM 2.38320746573303 0.0172744081474679 no 151 0.00858125948198189 215 1273210
SGTC_2136 5328288 199.296 µM 2.37692357607158 0.017508545272147 no 152 0.00872885235722758 108 262395
SGTC_721 1187-1332 279 µM 2.37407486398664 0.0176155773126986 no 153 0.00879649151251974 87 25730
SGTC_1424 4048-1941 275 µM 2.37018534925005 0.0177626158686693 no 154 0.00888958492687863 140 X1424
SGTC_186 3455-3465 67.277 µM 2.35901351553369 0.0181907900515237 no 155 0.0091617941976955 48 755278
SGTC_2154 5570129 200 µM 2.35811934784575 0.0182254371373394 no 156 0.00918389330336885 145 673366
SGTC_118 0083-0097 135.343 µM 2.35455719155318 0.0183640218477099 no 157 0.00927239486466818 400 5207356
SGTC_2213 7173844 200 µM 2.34665980639128 0.0186744714461768 no 158 0.00947127057542534 127 892728
SGTC_1075 aripiprazole 15.2 µM 2.34442376520663 0.018763178490097 no 159 0.00952825292271166 176 60795 An atypical antipschotic. YIL048W NEO1
SGTC_343 4130-2827 29.8 µM 2.34049342508923 0.0189199700006472 no 160 0.0096291387510458 151 1118244
SGTC_2041 5107442 45.335 µM 2.33424449903258 0.0191715501724998 no 161 0.00979146152639386 169 793005
SGTC_579 4491-1009 110 µM 2.32978887721577 0.0193526642358821 no 162 0.00990865616480071 187 1271041
SGTC_2900 5328528 85.29 µM 2.32229638204488 0.0196605002663382 no 163 0.0101084911157017 171 795359
SGTC_2178 5812956 200 µM 2.31878813595561 0.0198060628661199 no 164 0.0102032634021508 139 5403383
SGTC_2299 7976368 114.88 µM 2.31066561136881 0.0201465930370821 no 165 0.0104256660551723 138 2979718
SGTC_2942 9052777 62.25 µM 2.30928071694627 0.0202051462465411 no 166 0.0104640044929497 176 6469503
SGTC_3250 9135583 49.47 µM 2.30488584719885 0.0203919173380858 no 167 0.0105864837252683 103 7699353
SGTC_1275 0867-0008 21.1 µM 2.28176229807929 0.021398883172717 no 168 0.0112516888989372 145 3422836
SGTC_1913 st060213 96.1 µM 2.27417899542723 0.021738137254031 no 169 0.0114776133058122 200 688959
SGTC_2304 7443016 91.4 µM 2.27366409996751 0.0217613359310738 no 170 0.0114930951160157 126 939854
SGTC_947 3447-0010 211 µM 2.27309001237841 0.0217872261704913 no 171 0.0115103780905023 136 748350
SGTC_289 k017-0060 526 µM 2.26379454203836 0.0222100683380809 no 172 0.0117933771885224 106 5512909
SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.26267445783957 0.0222614843128558 no 173 0.0118278822361155 115 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_761 k216-0224 480 µM 2.25983556745604 0.0223922497942996 no 174 0.0119157290263184 159 1340404
SGTC_2347 9049783 174.81 µM 2.25897143641626 0.0224321819429566 no 175 0.011942580855 201 6467988 YPL169C MEX67
SGTC_282 k297-0036 65.7 µM 2.25330303131587 0.0226956150134293 no 176 0.0121200243824955 102 5061378
SGTC_2983 9022671 12.99 µM 2.244814642607 0.0230949767097644 no 177 0.0123900171843184 139 6405161
SGTC_757 1066-0008 322 µM 2.2301408164325 0.0237993059099028 no 178 0.0128690479229615 166 6842497
SGTC_892 0929-0076 29 µM 2.21493644141268 0.0245480623944196 no 179 0.0133822136927484 227 5751038
SGTC_2274 7947094 46.08 µM 2.20783727279782 0.0249043823395892 no 180 0.0136278093907253 190 2971028
SGTC_908 3448-7491 47.7 µM 2.20429698205633 0.0250836903836367 no 181 0.0137517325306243 328 1203031
SGTC_1214 0358-0031 63.7 µM 2.19009541487338 0.0258138818433997 no 182 0.014258658850509 177 4301366
SGTC_1978 st071761 42 µM 2.18558508828928 0.0260494753260582 no 183 0.0144229872787393 130 5147680
SGTC_503 tyrphostin 8 294 µM 2.18202918511994 0.0262364806770808 no 184 0.0145536894212904 196 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2714 st079313 56.9 µM 2.16245372638242 0.0272861620344992 no 185 0.0152916100894933 150 2939799
SGTC_1964 st076914 61 µM 2.15921642781803 0.0274630846413088 no 186 0.0154166900777116 146 24208661
SGTC_1849 st056239 19.2 µM 2.15269622548193 0.0278223262381897 no 187 0.0156712801712311 211 5393181
SGTC_831 k061-1017 217 µM 2.15062339749079 0.0279373491246721 no 188 0.0157529685114897 317 1240153
SGTC_330 1488-0319 80.1 µM 2.14357859098147 0.0283312355497434 no 189 0.0160333338550786 160 6846614
SGTC_2978 9011784 42.97 µM 2.14171005972669 0.0284364801774192 no 190 0.016108410356505 235 2994934
SGTC_3001 9076041 71.4286 µM 2.13191798937888 0.0289933490638737 no 191 0.0165067945359166 151 16004211
SGTC_2320 7373003 200 µM 2.1314829223784 0.0290182998546724 no 192 0.0165246889414016 173 5415828
SGTC_1965 Pectolinarigenin 58.4 µM 2.11971826177296 0.0296997890884274 no 193 0.0170149060002131 158 5320438 An anti-inflammatory.
SGTC_2095 5432005 200 µM 2.10409325798631 0.030625376846797 no 194 0.0176851564258391 157 783734
SGTC_3352 9151559 45.5865 µM 2.10151562324359 0.030780341548519 no 195 0.0177978640025033 181 17159339
SGTC_2682 pyrogallin 40.03 µM 2.0990983634743 0.0309262539601984 no 196 0.0179041153420253 231 822798 An ATP competetive kinase inhibitor.
SGTC_214 4373-3496 70 µM 2.09809357103691 0.0309870741866982 no 197 0.0179484401873465 312 3779166
SGTC_601 0986-0029 62.9 µM 2.09746546767508 0.0310251436220396 no 198 0.0179761954872261 243 24747981
SGTC_3122 9126309 49.47 µM 2.09662901028645 0.0310759015036213 no 199 0.0180132145719735 151 17591206
SGTC_2233 sulbentine 40.3845 µM 2.09445105430194 0.0312083865864934 no 200 0.0181099094291489 253 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1291 0993-0025 5.79 µM 2.09045637953999 0.0314525969042729 no 201 0.0182884114420517 160 4353356
SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.08939503279357 0.0315177462214764 no 202 0.0183360889994503 205 5282309
SGTC_532 1548-0774 215 µM 2.08813898287627 0.0315949912052198 no 203 0.0183926497318548 202 5932993
SGTC_1848 st056003 16.4 µM 2.08430851455842 0.0318315253271323 no 204 0.0185660566745745 181 146492
SGTC_627 1391-0720 175 µM 2.0804753577434 0.0320696878994874 no 205 0.0187409767919983 184 997839
SGTC_886 0866-0150 153 µM 2.07733905917258 0.0322656457672704 no 206 0.0188851382376667 227 271463
SGTC_2133 5320837 200 µM 2.07331696112593 0.0325183941695376 no 207 0.0190713956154329 192 2841355
SGTC_1621 st003705 32.4 µM 2.07159463153811 0.0326271235557528 no 208 0.019151630502822 220 24207032
SGTC_1020 4335-0961 93.3 µM 2.06560765581656 0.0330074117603198 no 209 0.0194327704826148 186 669075
SGTC_1021 4476-0760 85.3 µM 2.06126958595084 0.033285238801837 no 210 0.0196386640448272 214 746768
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.0601640392225 0.0333563494882024 no 211 0.0196914307289828 210 390807
SGTC_1364 1653-0028 37.6 µM 2.05833745404485 0.03347411268711 no 212 0.0197788756025139 209 5718652
SGTC_2909 7941780 10.49 µM 2.05783450357073 0.0335065988316877 no 213 0.0198030113552469 209 1243215
SGTC_116 0155-0182 31.788 µM 2.05422242322309 0.0337406704871625 no 214 0.0199770845480404 351 771486
SGTC_2991 9074669 71.4286 µM 2.04853758571576 0.034111785718164 no 215 0.0202536765901597 269 17333109
SGTC_2137 5261020 140 µM 2.04489990203112 0.0343510156224509 no 216 0.0204323637961261 219 763655
SGTC_800 3448-7362 155 µM 2.04468061687567 0.0343654807202711 no 217 0.0204431778960716 491 15991913
SGTC_87 0100-0052 35.5 µM 2.0420605428115 0.0345387008556474 no 218 0.020572763095686 434 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_297 0986-0032 24 µM 2.03348564424548 0.0351106318342239 no 219 0.0210017412424532 170 2847425
SGTC_1683 st010134 710 nM 2.02806031878221 0.0354764890022842 no 220 0.0212770460890547 236 3818134
SGTC_1070 indatraline 8.81 µM 2.02623529209721 0.0356002601641568 no 221 0.0213703393311823 223 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.02124092127068 0.0359407832254991 no 222 0.0216274157639129 231 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2433 5607874 27.82 µM 2.01656335812882 0.0362621211056245 no 223 0.0218705500487659 236 2252428
SGTC_1727 st034309 9.9045 µM 2.01594541883402 0.0363047474591961 no 224 0.021902841769075 293 870305
SGTC_1723 st034307 2.5525 µM 2.00305798683275 0.0372031281645943 no 225 0.0225855323967557 225 867466
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.00117640541032 0.0373357998338085 no 226 0.0226866913588246 191 756377
SGTC_218 alverine citrate 93.75 µM 1.98892034848007 0.038209469588217 no 227 0.0233549976866437 178 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_159 3970-0959 50 µM 1.98443960356356 0.0385330109411281 no 228 0.0236034273737016 433 6615653
SGTC_1781 st038725 66.3 µM 1.97822849096385 0.0389851859633151 no 229 0.0239514679904006 333 4270275 YIL048W NEO1
SGTC_2372 9071633 200 µM 1.96011529514995 0.0403285635547843 no 230 0.0249911579520548 209 21321366
SGTC_686 1319-0111 510 µM 1.95826287560638 0.0404680432383928 no 231 0.0250995873077618 235 4562600
SGTC_1160 4092-0570 10.5 µM 1.95810535353216 0.040479922058595 no 232 0.0251088258541749 269 4994975
SGTC_2256 7954252 200 µM 1.95778656547374 0.0405039706908374 no 233 0.0251275312452839 161 2972920
SGTC_707 0865-0008 204 µM 1.95569580936307 0.0406619801101494 no 234 0.0252504993486771 193 723043
SGTC_3067 9117431 49.47 µM 1.94140573368705 0.0417553963521709 no 235 0.026104541692675 193 17150885
SGTC_51 1013-0126 23.419 µM 1.93862984016586 0.0419705335314582 no 236 0.0262732136607316 232 1627850
SGTC_1187 1391-0724 117 µM 1.93415479077588 0.04231924719027 no 237 0.0265470495079002 245 6997986
SGTC_58 0957-0393 9 µM 1.93218686510668 0.0424733360162389 no 238 0.0266682228973647 687 6997992
SGTC_1349 flufenamic acid 69 µM 1.9297070908597 0.0426681484484613 no 239 0.0268215704384208 217 3371 A non-steroidal anti-inflammatory.
SGTC_418 lividomycin a 100 µM 1.92878740390319 0.0427405829496687 no 240 0.0268786301014061 215 72394 An antibiotic.
SGTC_2150 5556613 200 µM 1.9250025397088 0.0430397255928152 no 241 0.0271145202572145 247 743190
SGTC_2817 7995342 71.43 µM 1.9032992269973 0.0447878872412408 no 242 0.0285007558342265 217 18879975
SGTC_3282 9108498 15.4605 µM 1.89972133638792 0.0450814948363719 no 243 0.0287348493971011 263 16459645
SGTC_3143 9086658 49.47 µM 1.89889087031457 0.045149865265013 no 244 0.0287894129855439 319 25236626
SGTC_788 1182-0090 188 µM 1.89499143669261 0.0454720134003574 no 245 0.029046768084586 367 5715185
SGTC_141 0443-0274 32.331 µM 1.88828844314578 0.0460300925080207 no 246 0.0294936189774998 394 1627241
SGTC_692 k241-0027 77.8 µM 1.87723635789277 0.0469622721219279 no 247 0.0302428532311877 247 3600480
SGTC_1843 st055809 45.5 µM 1.87639076736404 0.04703421178753 no 248 0.0303008207133738 237 16413835
SGTC_2287 7945887 168.79 µM 1.87627628254504 0.0470439585137925 no 249 0.0303086760250434 244 1245853
SGTC_2674 ligustilide 100 µM 1.87520731556037 0.0471350437655197 no 250 0.0303821040713262 193 5319022 A signalling regulator.
SGTC_2438 5259590 200 µM 1.87455453395165 0.0471907359097468 no 251 0.0304270165151112 250 1201127
SGTC_1381 2324-0066 62.1 µM 1.86980200636035 0.0475977899604284 no 252 0.0307556588287218 303 10885928
SGTC_204 PMA1.184 62.41 µM 1.85917950812593 0.0485177759803995 no 253 0.0315008492040892 293 2252213 YGL008C PMA1
SGTC_876 0720-0963 56.8 µM 1.85065336351462 0.0492664426392768 no 254 0.0321097186840055 258 765861
SGTC_2512 diallyl trisulfide 49.23 µM 1.85059642026903 0.0492714735664487 no 255 0.0321138175498096 189 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_679 0422-0091 41.4 µM 1.84947508107678 0.0493706273178821 no 256 0.0321946213835513 319 627384 YHR062C RPP1
SGTC_192 3455-0609 60.9 µM 1.84653953356072 0.0496309558550834 no 257 0.0324069523228803 255 3769639
SGTC_2085 5307070 144.047 µM 1.8440507441926 0.0498525222119017 no 258 0.0325878726380098 236 2840351
SGTC_59 0330-0160 1.33 µM 1.83280893656209 0.0508631801787864 no 259 0.0334154948553313 463 4293482
SGTC_3070 9117005 49.47 µM 1.83159353743347 0.0509734169014408 no 260 0.0335060001839 188 8779016
SGTC_161 4065-0411 162.148 µM 1.830017657576 0.0511166322889156 no 261 0.0336236492499976 355 1906281 YLR208W SEC13
SGTC_1939 st074455 53.6 µM 1.82881340239475 0.0512262902580158 no 262 0.0337137832602706 293 1644229
SGTC_398 bronopol 33.3 µM 1.82825991805774 0.051276752589092 no 263 0.0337552761379974 283 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2871 9038510 12.99 µM 1.82003751626818 0.0520310734090253 no 264 0.0343766459319362 278 4945164
SGTC_2345 9052315 157.45 µM 1.8180660400301 0.0522132400364803 no 265 0.0345270198614457 284 6469265
SGTC_3005 9076496 71.4286 µM 1.81385830923303 0.0526037331988417 no 266 0.0348497713462786 230 21368410
SGTC_3027 9089541 49.47 µM 1.81021482122582 0.0529437316917492 no 267 0.0351312400370418 292 9943819
SGTC_2785 7756463 72.73 µM 1.80194833992014 0.0537215961469216 no 268 0.0357767668771753 280 2201551
SGTC_147 4466-0538 29.23 µM 1.80029975655955 0.0538778028055416 no 269 0.0359066596688925 305 6742687 YHR072W ERG7
SGTC_2430 5571206 200 µM 1.79871630758585 0.0540281762352289 no 270 0.0360317839839543 338 1731771
SGTC_2719 novobiocin 32.65 µM 1.79642224782456 0.0542466224383019 no 271 0.0362136940914983 176 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1213 1315-0166 115 µM 1.7959806498078 0.0542887526256743 no 272 0.0362487972694548 247 768401
SGTC_2597 laccaic acid a 100 µM 1.78807620222916 0.0550472554643284 no 273 0.0368818572341186 337 5491415 A textile dye.
SGTC_2659 sanguinarine 24.21 µM 1.78787262063762 0.0550669009919819 no 274 0.0368982805510365 276 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1575 cyproterone acetate 48 µM 1.78761692877583 0.0550915829834228 no 275 0.0369189161736955 290 9880 An androgen receptor antagonist and liver toxin.
SGTC_1863 st057641 20.1 µM 1.78599911606051 0.0552479534583792 no 276 0.0370497006293788 307 3921635
SGTC_593 1203-0218 61.7 µM 1.77569502297596 0.0562521423038833 no 277 0.0378915990888624 286 3666956
SGTC_1763 st044482 94.5 µM 1.77301464679008 0.0565157037430381 no 278 0.0381131399398647 304 88505
SGTC_1797 st048695 56.8 µM 1.77255698129445 0.0565608031061186 no 279 0.0381510727057058 325 592262 YIL048W NEO1
SGTC_2951 9072950 58.06 µM 1.76844174001475 0.0569676029804364 no 280 0.0384935419053563 322 16488155
SGTC_1178 0988-0033 191 µM 1.76814722810015 0.0569968041816041 no 281 0.0385181468701301 332 5392207
SGTC_1882 5615643 20 µM 1.76669090725129 0.0571413733554857 no 282 0.0386400034942852 254 2253075
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.76666993583753 0.0571434572968222 no 283 0.0386417605541342 272 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_756 0508-1999 28.3 µM 1.76494181065434 0.0573153877496607 no 284 0.0387867729068702 295 6753853
SGTC_1912 st060209 90.8 µM 1.75772469806873 0.0580378187414403 no 285 0.0393971816758914 302 688787
SGTC_3022 9087993 49.47 µM 1.75667139478372 0.0581438499105976 no 286 0.0394869179935936 243 17173644
SGTC_1286 0929-0070 131 µM 1.75478833547733 0.0583337879944273 no 287 0.0396477597687395 327 1420408
SGTC_502 l-744,832 89.3 µM 1.75447285071618 0.05836565752968 no 288 0.0396747589784743 300 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3152 9099253 49.47 µM 1.75442653592217 0.0583703372931337 no 289 0.0396787238602546 449 25236131
SGTC_1991 st073000 8.92 µM 1.74610988397348 0.0592154609855591 no 290 0.0403959298210624 383 4301969 YIL048W NEO1
SGTC_100 0086-0128 49.5915 µM 1.74069872621138 0.0597704662335285 no 291 0.0408682008442698 379 93297
SGTC_2158 5657123 3.6195 µM 1.7400952628145 0.0598326133099254 no 292 0.0409211459711651 258 2858827
SGTC_1144 3486-0183 12.5 µM 1.73373314433162 0.0604908936093967 no 293 0.0414827213938114 332 6744069
SGTC_1862 st057513 3.81 µM 1.72940495269453 0.0609419554843564 no 294 0.041868322117568 283 5393163
SGTC_3279 9140807 49.47 µM 1.72510248129346 0.061392938805347 no 295 0.0422545027332029 279 45595718
SGTC_372 0155-0182 15.9 µM 1.72478101998118 0.061426738644478 no 296 0.0422834717437019 323 771486
SGTC_1438 4092-1045 4 µM 1.72176015382906 0.0617450761528424 no 297 0.0425564877248474 290 1351342
SGTC_609 0986-0026 86.3 µM 1.72039743398904 0.0618890998309406 no 298 0.0426801115609539 355 2848610
SGTC_2835 9006588 71.43 µM 1.72015371482388 0.061914885737234 no 299 0.0427022519620988 350 2345538
SGTC_1362 1611-0397 101 µM 1.72014659403114 0.0619156392553869 no 300 0.0427028989823074 302 27816
SGTC_1131 3454-3128 32.3 µM 1.71834005460578 0.0621070375480215 no 301 0.0428673037204716 374 710982
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.71479089834159 0.0624844056516434 no 302 0.0431917854246986 335 4174840
SGTC_781 4335-2806 94.4 µM 1.7139042923006 0.0625789535609153 no 303 0.0432731523142066 351 845254
SGTC_673 1082-0474 110 µM 1.70592843093065 0.063434523170796 no 304 0.0440107027805099 421 3098046
SGTC_3193 9111931 49.47 µM 1.70451178382296 0.0635874344458719 no 305 0.0441427582405075 319 17087244
SGTC_1335 1486-0900 202 µM 1.70339398724073 0.0637082904537381 no 306 0.044247181092162 361 X1335
SGTC_2889 9059656 51.95 µM 1.69840996103551 0.0642493386062218 no 307 0.0447152066857922 319 3949838
SGTC_2283 7944793 200 µM 1.68972476367211 0.0652006985022314 no 308 0.0455403116707597 350 2970533
SGTC_235 0330-0087 5 mM 1.68785653553778 0.0654067620005999 no 309 0.0457193859246361 361 46494818 YHR062C RPP1
SGTC_1228 0124-0032 52.5 µM 1.68163259513576 0.0660969016378651 no 310 0.0463200529814969 348 X1228
SGTC_791 1348-1292 225 µM 1.67829762919309 0.0664690123783667 no 311 0.0466445053264233 416 5437054
SGTC_395 anisomycin 6.25 µM 1.67538286683335 0.0667955637694255 no 312 0.0469295680023712 264 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.67171716207545 0.0672080065262779 no 313 0.0472900541532379 341 3256 An antibiotic and ribosome inhibitor.
SGTC_2932 9016711 44.54 µM 1.67112975443472 0.0672742807093544 no 314 0.0473480257007807 376 7117328
SGTC_2333 9017922 200 µM 1.67058612954994 0.0673356601141829 no 315 0.0474017270333712 327 3163164
SGTC_1413 3910-0535 34.4 µM 1.67041666013695 0.0673548033545772 no 316 0.0474184778409382 332 2876951
SGTC_3275 9138069 49.47 µM 1.65528846982262 0.0690806901861756 no 317 0.048932998334953 306 17617007
SGTC_1167 k781-0610 148 µM 1.64836526688003 0.0698817970866241 no 318 0.0496388694836148 388 4525169
SGTC_1692 fluoroquinolonic acid 71 µM 1.64662944823103 0.0700837710977871 no 319 0.0498171168590876 298 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1442 4112-3290 3 µM 1.64520891128847 0.0702493938732873 no 320 0.049963368227836 362 704353
SGTC_144 4161-2749 112.381 µM 1.64225281236853 0.0705950151559843 no 321 0.0502688109459689 299 797501 YMR168C CEP3
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.63692616148049 0.0712210940212777 no 322 0.050822949408735 290 61125 An anti-inflammatory.
SGTC_1204 4049-0315 18.3 µM 1.62860653519966 0.0722074754100423 no 323 0.0516981699587989 363 588402
SGTC_101 0490-5701 117.494 µM 1.62592899432822 0.0725271438421255 no 324 0.0519823806509686 298 4661669
SGTC_3307 9126885 69.2785 µM 1.61447367667902 0.0739070318544188 no 325 0.05321236102586 401 24824909
SGTC_614 0462-0418 107 µM 1.61202803983476 0.0742042111597405 no 326 0.0534779190959076 339 5188303
SGTC_977 1348-1378 135 µM 1.60758965758398 0.0747458669930008 no 327 0.0539625394161493 352 X977
SGTC_1127 asiatic acid 681.4 nM 1.6054902100894 0.0750031302267021 no 328 0.054192982975105 372 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2336 9001819 198.65 µM 1.60521723183364 0.0750366301378303 no 329 0.0542230032604027 414 2989602
SGTC_163 TUB2.036 7.546 µM 1.59743180506078 0.0759968692682099 no 330 0.0550847437880058 559 15992207 YJR013W GPI14
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.58983937205949 0.0769422880790606 no 331 0.0559355082759726 320 17037758
SGTC_1722 st034304 3.6505 µM 1.58873491252407 0.0770805583123432 no 332 0.056060126657542 395 4036148 YLR033W RSC58
SGTC_1284 0929-0043 16 µM 1.57896275778073 0.078312198471237 no 333 0.0571722998047855 413 1239883
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.57870897934676 0.0783443812698893 no 334 0.0572014121319978 355 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1094 duloxetine 25.4 µM 1.56958441395059 0.0795081829814128 no 335 0.0582559134312764 390 60834 A selective serotonin reuptake inhibitor.
SGTC_3079 9117512 49.47 µM 1.56652878157047 0.0799008266991415 no 336 0.0586124379936063 316 7185044
SGTC_599 1935-0052 86.5 µM 1.56521141050349 0.0800705583741936 no 337 0.0587666734552908 405 9557311
SGTC_2254 7938975 95.19 µM 1.5637686532888 0.0802567575303623 no 338 0.0589359541676159 469 2969277
SGTC_1689 st020265 53.493 µM 1.5585899080259 0.0809278112166304 no 339 0.0595467365799248 359 5758320 YPR016C TIF6
SGTC_206 4546-0025 72.014 µM 1.55713153956561 0.0811175465126339 no 340 0.0597196291073612 468 6620745 YIL048W NEO1
SGTC_3314 9135860 59.4275 µM 1.55227801967862 0.081751412453383 no 341 0.0602978574530664 399 25252478
SGTC_1504 k297-0033 30 µM 1.55218452775525 0.0817636589747329 no 342 0.0603090385609198 314 4388117
SGTC_1824 st053723 68.6 µM 1.55163664995798 0.0818354533691185 no 343 0.0603745942837304 406 675225
SGTC_745 0469-0705 296 µM 1.54990186611498 0.0820630943947272 no 344 0.0605825358472424 441 3486736
SGTC_1251 0490-5699 265 µM 1.54858527277928 0.0822361779931881 no 345 0.0607407242305883 453 3883818
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.54760533495037 0.0823651821505676 no 346 0.060858673087854 421 1273210
SGTC_2365 9042475 200 µM 1.54737961715592 0.0823949184060584 no 347 0.0608858666568105 411 6464479
SGTC_2832 7992762 51.95 µM 1.54103453941429 0.0832341354209725 no 348 0.0616541900055906 358 2985177
SGTC_2116 5511452 16.8835 µM 1.53979794569429 0.0833984363066003 no 349 0.0618048064245083 412 870744
SGTC_539 4859-0462 2.54 µM 1.53616064192746 0.0838831222206573 no 350 0.062249493141788 382 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1476 4112-3294 3.34 µM 1.53395715449318 0.0841777733254461 no 351 0.0625200968481202 380 704369
SGTC_124 0136-0217 7.121 µM 1.53358456377636 0.0842276729819217 no 352 0.0625659441107279 475 3976905
SGTC_1490 4089-0339 670 nM 1.53284862403595 0.0843262998197145 no 353 0.0626565784513049 335 742542
SGTC_3156 9099931 49.47 µM 1.53198220858728 0.0844425233826896 no 354 0.0627634125905492 395 18111053
SGTC_2361 9034121 116 µM 1.53037537258174 0.084658387242742 no 355 0.0629619206453277 388 6496917
SGTC_2878 9043973 25.97 µM 1.5246756594628 0.0854274302137682 no 356 0.0636700078758848 359 6465167
SGTC_744 1594-0068 283 µM 1.52300990562177 0.0856531698225984 no 357 0.0638781136050868 462 668392
SGTC_2952 9073731 13.78 µM 1.51762086638468 0.0863865412959134 no 358 0.0645550017354264 455 16457353
SGTC_3047 9092122 49.47 µM 1.51240440298189 0.0871008900419361 no 359 0.065215507753936 413 17173831
SGTC_2120 5538279 151.968 µM 1.51209918256369 0.0871428235001306 no 360 0.0652543163949212 398 2058197
SGTC_2947 9072639 7.68 µM 1.50711107918063 0.0878302643415343 no 361 0.0658910937032696 472 16488146
SGTC_1106 tegaserod maleate 11.7 µM 1.50661208280611 0.0878992560020004 no 362 0.0659550592366946 446 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_920 mycophenolic acid 780.421 nM 1.50604021222725 0.0879783730042697 no 363 0.0660284255554528 427 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_169 k015-0017 16.025 µM 1.5017096720597 0.0885792178069891 no 364 0.0665860524522804 381 1840002
SGTC_2202 7226349 200 µM 1.49964968066971 0.0888661037798509 no 365 0.066852585708545 345 844334
SGTC_2927 9011802 47.9 µM 1.49564183339911 0.0894262403884555 no 366 0.0673735077655046 423 43912568
SGTC_2805 7950783 58.44 µM 1.48718756342801 0.0906164141700803 no 367 0.0684826398985261 498 1178958 YDL195W SEC31
SGTC_2441 5730946 39.09 µM 1.48346794366764 0.091143762960754 no 368 0.0689750636461701 431 1774275
SGTC_3113 9123498 49.47 µM 1.48061415292533 0.0915498992881022 no 369 0.0693547108888661 402 8897275
SGTC_2669 eugenol 100 µM 1.47807021518281 0.0919130682531788 no 370 0.0696944926696671 342 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2477 5967686 25.23 µM 1.47683070979685 0.0920904043925545 no 371 0.0698605111824111 440 776118
SGTC_1227 3909-8010 46.6 µM 1.47505715490596 0.0923445874078847 no 372 0.0700985890035634 413 15982272
SGTC_3243 9134147 49.47 µM 1.47435051374115 0.0924460065917197 no 373 0.070193620538437 407 24282180
SGTC_1057 3448-5381 134 µM 1.47334787136978 0.0925900501224543 no 374 0.070328629338252 460 5497911
SGTC_401 neomycin 50 µM 1.47311075339745 0.0926241396810531 no 375 0.0703605871598062 384 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_66 0109-0187 42.4 µM 1.4716641901268 0.092832307738386 no 376 0.0705557911273094 422 759417
SGTC_1777 st045864 34.765 µM 1.47067390570327 0.0929750142106932 no 377 0.0706896631821173 445 4691462
SGTC_582 0987-0078 156 µM 1.46802952532423 0.0933568813552665 no 378 0.0710481015139938 600 1625765
SGTC_3268 9137683 49.47 µM 1.46483019285009 0.0938204348718581 no 379 0.0714836260596945 372 1953228
SGTC_410 α-linolenic acid 100 µM 1.46339148280854 0.094029443504632 no 380 0.0716801439514434 481 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2712 st079126 47.7 µM 1.46038672050497 0.0944670681331405 no 381 0.0720919101731773 412 3152970
SGTC_2906 7926292 26.41 µM 1.45195636795061 0.0957029101565626 no 382 0.0732568688246983 457 2966319
SGTC_1782 st039423 80.636 µM 1.45152512597482 0.0957664460928645 no 383 0.073316845469821 420 2068169
SGTC_1633 st005664 67.9 µM 1.4507200688805 0.0958851401518823 no 384 0.0734289124018042 463 2063822
SGTC_316 k060-0003 58.6 µM 1.45012826268271 0.0959724624210538 no 385 0.0735113775341073 434 6152314
SGTC_1521 st012942 49.4 µM 1.44892940323732 0.0961495358972848 no 386 0.0736786494179539 480 24207259
SGTC_2894 9048625 32.47 µM 1.44793642410239 0.096296382279538 no 387 0.0738174158550096 430 4092861
SGTC_1944 st076371 56.9 µM 1.4466863867118 0.0964814779159028 no 388 0.0739923894590118 450 24208455
SGTC_911 3456-4043 236 µM 1.44511020607299 0.0967152386957863 no 389 0.0742134663403374 479 914281
SGTC_2883 9059145 45.46 µM 1.4443992514139 0.0968208152435106 no 390 0.074313350592151 403 16476510
SGTC_1445 4239-0156 97.7 µM 1.43782125229708 0.0978016623517326 no 391 0.0752423888517988 519 4008346
SGTC_903 1134-0042 114 µM 1.43737483851123 0.0978684902034696 no 392 0.075305757149393 449 701009
SGTC_1353 1498-1206 8.11 µM 1.4349049691325 0.0982388329573128 no 393 0.0756570897554216 533 6756808
SGTC_2902 5787006 60.46 µM 1.43324425034677 0.0984884247229316 no 394 0.0758940239366304 444 591003
SGTC_1133 3473-0247 50 µM 1.43095189549585 0.098833708265374 no 395 0.0762220011514739 493 711311
SGTC_1841 st054148 70 µM 1.42439797972046 0.0998257697477611 no 396 0.0771656493631482 424 675442
SGTC_2961 9083290 32.55 µM 1.4234132321735 0.0999754566411774 no 397 0.0773081994225121 416 17741490
SGTC_72 0744-0168 198.391 µM 1.42276154125149 0.100074607235435 no 398 0.0774026468194515 454 677577
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.42233881398552 0.100138960856826 no 399 0.0774639581203725 450 2724278 An inhibitor of dopamine biosynthesis.
SGTC_3056 9094900 49.47 µM 1.41923194499666 0.100612860309678 no 400 0.0779157027634547 465 25236784
SGTC_723 4182-0001 115 µM 1.41783997601483 0.100825711105283 no 401 0.0781187449900851 442 744821 YLR208W SEC13
SGTC_2408 sulbentine 18.36 µM 1.41701777277131 0.100951591201912 no 402 0.0782388656584957 486 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3222 9128301 49.47 µM 1.41398759409668 0.101416503625877 no 403 0.0786827725304846 462 4911358
SGTC_2732 terfenadine 20 µM 1.4113519984756 0.10182214274468 no 404 0.0790704246180691 392 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2807 7945238 51.95 µM 1.41027149503845 0.101988781698991 no 405 0.0792297660036386 493 17148797
SGTC_396 dithiazanine 1.25 µM 1.40984195699859 0.102055081630258 no 406 0.0792931772855895 426 10578 An antihelmenthic.
SGTC_1910 st062352 60.4 µM 1.40767826789694 0.10238952761991 no 407 0.0796131798766817 475 2245730
SGTC_2294 7971431 200 µM 1.4003772195977 0.103523947145957 no 408 0.0807001940119228 402 5741572
SGTC_2364 9055074 200 µM 1.39190094700282 0.104852379682711 no 409 0.0819761975262199 449 6470630
SGTC_2355 9061122 103.12 µM 1.38788337022332 0.105486322839284 no 410 0.0825862812475737 459 5302957
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.38752316006092 0.105543296394468 no 411 0.0826411469783195 485 115019
SGTC_2646 retinol 96.75 µM 1.38673953008088 0.10566731807801 no 412 0.0827606010250107 458 445354 A vitamin A analog and teratogen.
SGTC_1078 idebenone 36.1 µM 1.382361969875 0.106362074018265 no 413 0.0834302935083188 556 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2964 9083345 53.42 µM 1.38043196308018 0.106669428005024 no 414 0.0837268422576236 447 17741579
SGTC_2442 5158906 48.48 µM 1.37322029678148 0.107823559268685 no 415 0.0848419358554414 499 1893835
SGTC_2760 etidronate 98.04 µM 1.37116713308494 0.10815377965985 no 416 0.0851614306481243 489 3305 A chelator and antioxidant.
SGTC_1992 st073643 23.3 µM 1.36928865328016 0.108456541963295 no 417 0.0854545317099429 485 3161292
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.36899106804431 0.108504560895011 no 418 0.0855010334709037 553 165506
SGTC_37 0566-0070 1.56 µM 1.36739174658139 0.108762892506592 no 419 0.085751273964239 556 1626686
SGTC_1769 st044406 64.4 µM 1.36730834350614 0.10877637637452 no 420 0.085764338790181 548 670903
SGTC_71 0417-1750 47.813 µM 1.36611061138563 0.108970147651707 no 421 0.0859521240864133 539 6811472
SGTC_3088 9117578 49.47 µM 1.36548850492434 0.109070891015514 no 422 0.086049781785895 474 678341
SGTC_1663 st014140 55.4 µM 1.36531549468119 0.109098920032071 no 423 0.0860769555229942 567 4207120
SGTC_3046 9092212 49.47 µM 1.36526638480003 0.109106877161192 no 424 0.0860846701030481 473 25236637
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.36318474687407 0.109444542408392 no 425 0.0864121465884647 564 6708784 An antioxidant flavonoid
SGTC_2222 6885208 172.143 µM 1.36177807285026 0.109673145419296 no 426 0.0866339667764911 437 609514
SGTC_1268 0828-0275 2.46 µM 1.35875176280635 0.110166122204044 no 427 0.0871126316989428 515 745337
SGTC_563 tetrahydrosecaminediol 614 µM 1.35773225682188 0.110332554044093 no 428 0.0872743287104611 525 334274 A psychoactive constituent of the cannabis plant.
SGTC_984 1492-0255 2.91 µM 1.35699010837789 0.110453821293874 no 429 0.0873921767599637 469 1585198
SGTC_1695 st026914 34.495 µM 1.35495329972729 0.110787127286433 no 430 0.0877162182151171 515 3289191
SGTC_1041 0206-0046 107 µM 1.354128922748 0.110922234060955 no 431 0.0878476251135083 501 50494
SGTC_452 diindolylmethane 8 µM 1.35318597704522 0.111076917675486 no 432 0.0879981120009173 449 3071 Inhibits expression of several cancer promoting factors.
SGTC_1819 st053448 58.6 µM 1.35145766246661 0.111360836470656 no 433 0.0882744366387273 500 2857616
SGTC_2077 5212015 200 µM 1.3483269721854 0.111876452419071 no 434 0.0887766203265351 500 780900
SGTC_2280 7785178 200 µM 1.34368708743068 0.112643765091851 no 435 0.0895247972961301 478 2954328
SGTC_1768 st044301 37.178 µM 1.34332597118192 0.112703641302842 no 436 0.0895832230333897 538 3931349
SGTC_2406 ethylparaben 405.7 µM 1.34229843594537 0.112874139903466 no 437 0.0897496251809581 448 8434 A possible steroid mimic.
SGTC_655 k060-0012 42 µM 1.34200382060776 0.1129230592822 no 438 0.0897973784348671 518 5994525
SGTC_2483 5729050 27.16 µM 1.34033047519304 0.113201196872807 no 439 0.0900689639451061 625 2865180
SGTC_1397 3532-0190 20.1 µM 1.33964193828496 0.11331578487546 no 440 0.0901808911707001 433 5322280
SGTC_1177 0983-0204 23.6 µM 1.33415806573859 0.114231378787182 no 441 0.0910760296618646 566 766818
SGTC_2383 9036125 200 µM 1.33328046716701 0.114378391347309 no 442 0.0912198906153444 470 79580
SGTC_2616 abietic acid 100 µM 1.32810615993307 0.115247913759403 no 443 0.0920715193893145 555 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3115 9123671 49.47 µM 1.3245152972151 0.115854099934904 no 444 0.0926659830356564 515 3286988
SGTC_2210 7115885 190.385 µM 1.32349256858067 0.116027163870288 no 445 0.0928358130054285 550 2927039
SGTC_131 0141-0277 33.849 µM 1.32234435732795 0.116221680289261 no 446 0.0930267541918599 537 1547771
SGTC_2713 st079149 53.4 µM 1.32198624260967 0.116282395180308 no 447 0.0930863660375659 572 3103253
SGTC_2640 pentamidine 10.38 µM 1.32060071445659 0.116517510060735 no 448 0.0933172672534375 589 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2996 9066192 71.4286 µM 1.31601239942783 0.117298522978041 no 449 0.0940849404863227 533 6472854
SGTC_969 1313-0238 134 µM 1.3141340066712 0.117619326180755 no 450 0.0944005559491619 586 5212874
SGTC_749 1000-0129 128 µM 1.31319984286544 0.117779099318519 no 451 0.0945578084662425 577 708470
SGTC_2277 7947813 106.88 µM 1.30923471758484 0.118458977187199 no 452 0.0952274277316022 520 1246798
SGTC_1208 2323-2347 50.3 µM 1.30830402559836 0.118618958897273 no 453 0.0953851051419837 548 5412760
SGTC_2026 5148700 152 µM 1.30693746393995 0.118854141175525 no 454 0.0956169755528424 558 79838
SGTC_2035 5154463 94.595 µM 1.30685783693584 0.118867854956024 no 455 0.0956304989866146 569 2769623
SGTC_1685 st024049 53.0905 µM 1.30263531622864 0.11959668118726 no 456 0.0963496473812319 496 1941139
SGTC_3109 9122853 49.47 µM 1.30195516259015 0.119714372916006 no 457 0.0964658567824375 555 1234709
SGTC_1881 5652484 16 µM 1.2999630887258 0.12005954519776 no 458 0.0968068101704638 546 2255129
SGTC_3102 9121669 49.47 µM 1.29826736334684 0.120353920511927 no 459 0.0970977385866389 491 41905072
SGTC_2109 5483026 200 µM 1.29785987026512 0.12042473638816 no 460 0.0971677459795911 564 759335
SGTC_2028 5153890 36.43 µM 1.29665297129306 0.120634648570861 no 461 0.0973753087731631 541 2830968 YPR165W RHO1
SGTC_1613 st002381 52.1 µM 1.29548229579587 0.120838506516874 no 462 0.0975769524289805 528 551167
SGTC_3163 9099914 49.47 µM 1.29302233160517 0.12126766706869 no 463 0.0980016677805191 471 16268368
SGTC_1790 st045711 43.5 µM 1.29247661581425 0.121363016668238 no 464 0.098096069490294 549 585119
SGTC_680 0417-1641 114 µM 1.28637101097407 0.122433406972953 no 465 0.0991568052564081 513 2835990
SGTC_385 1494-0393 12.4 µM 1.28235772085489 0.12314058634723 no 466 0.0998585941609426 569 3090647
SGTC_466 geldanamycin 89.2 µM 1.28175517662087 0.123247006973885 no 467 0.099964271257696 422 5288382 HSP90 inhibitor.
SGTC_1857 st056007 79.3 µM 1.28115239256945 0.123353534426459 no 468 0.100070072110974 518 619834
SGTC_1126 isoteolin 1.0172 µM 1.27984216459703 0.123585307880634 no 469 0.100300325708195 553 133323
SGTC_2359 9039622 200 µM 1.27945779981932 0.123653358106209 no 470 0.100367945551221 584 6463596
SGTC_1151 3909-8316 15.3 µM 1.27845422159488 0.123831161238899 no 471 0.100544658096005 564 800431
SGTC_1096 rimcazole 32.2 µM 1.27756027005649 0.123989692545242 no 472 0.100702258350743 508 18528119 A dopamine reuptake inhibitor.
SGTC_1758 st042942 75.2445 µM 1.27719499623734 0.124054510218595 no 473 0.100766706558663 543 669317
SGTC_2750 bromebric acid 70.15 µM 1.27695138156785 0.124097752708407 no 474 0.100809706177743 625 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1307 1187-1599 12.2 µM 1.27347657625378 0.12471569150189 no 475 0.101424489674182 562 1538471
SGTC_258 haloperidol 50.781 µM 1.27135779721071 0.125093536319592 no 476 0.101800694638493 557 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2307 7538926 6.34 µM 1.27131338819719 0.125101464385751 no 477 0.101808590642648 595 96582
SGTC_327 1273-0057 3.96 µM 1.2691390980991 0.125490056182571 no 478 0.102195728841326 534 3108138
SGTC_2513 baicalein 25.65 µM 1.26907783530111 0.125501017333756 no 479 0.102206652337605 566 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_342 k048-0088 23.3 µM 1.26779390064816 0.125730892914153 no 480 0.102435780457504 560 6820570
SGTC_2903 5923464 63.88 µM 1.26236944052705 0.126705329111997 no 481 0.103407940110401 539 2876576
SGTC_1509 1326-1131 80 µM 1.26220957722078 0.126734126106948 no 482 0.103436691703549 530 768313
SGTC_228 caffeine 993.056 µM 1.26198985984875 0.126773712356679 no 483 0.103476217584296 517 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_324 1315-0088 19.6 µM 1.26154954449727 0.126853069427144 no 484 0.103555460756906 492 6787421
SGTC_2311 7694451 200 µM 1.25689061661928 0.127694856898744 no 485 0.10439662339039 582 2163142
SGTC_2830 7992007 71.43 µM 1.25652770742607 0.127760590927053 no 486 0.104462353371673 553 1952075
SGTC_88 0180-0332 8.668 µM 1.25585511773452 0.127882479804835 no 487 0.104584251845691 583 3101745
SGTC_2963 9082507 9 µM 1.25428487587675 0.128167358576024 no 488 0.104869239571914 544 16459611
SGTC_1023 4482-3888 16 µM 1.25304336523589 0.128392909561283 no 489 0.105094962624281 564 3303168
SGTC_2924 9010168 62.78 µM 1.25171948806671 0.128633727882509 no 490 0.105336048174116 603 2993929
SGTC_1518 st038567 90.8 µM 1.24324945816575 0.130181875906359 no 491 0.106887961250932 545 77966
SGTC_1162 k048-0130 20.1 µM 1.24136063482537 0.130528865021846 no 492 0.107236277203042 594 6797406
SGTC_276 colchicine 750 µM 1.2395919343605 0.130854366158725 no 493 0.107563182718626 615 2833 A microtubule depolymerizer.
SGTC_2872 9044037 25.97 µM 1.23799367720885 0.131148982039928 no 494 0.107859202638868 515 6465195
SGTC_475 α-linolenic acid 10 µM 1.2318862849705 0.132279011561209 no 495 0.108995782673949 614 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1645 Cervolide 78 µM 1.22776074512901 0.133046133352326 no 496 0.109768397818428 543 23173 A fragrance.
SGTC_983 1491-0821 12.2 µM 1.22366195668473 0.133811307918182 no 497 0.110539888326263 583 46495113
SGTC_3313 9133968 57.047 µM 1.2235424876144 0.133833656052133 no 498 0.110562433427003 628 1494643
SGTC_2782 7736369 71.43 µM 1.22334586586664 0.133870442112414 no 499 0.110599545244942 635 2950836 YOL077C BRX1
SGTC_3184 9108758 49.47 µM 1.22325097892107 0.133888197043925 no 500 0.110617458090568 574 902885
SGTC_2195 6536160 144.242 µM 1.2215521325308 0.134206353451994 no 501 0.110938519833511 535 3834386
SGTC_3289 9119912 71.43 µM 1.22126150156179 0.134260834188843 no 502 0.110993512425046 588 17014829
SGTC_50 0929-0078 56.389 µM 1.22069568022923 0.134366944784404 no 503 0.111100631972333 598 1377751
SGTC_935 2996-0153 430 µM 1.22016041378554 0.134467378298853 no 504 0.111202035087494 604 23738523
SGTC_1669 st015249 58.4 µM 1.21301055888213 0.135813867996828 no 505 0.112562891790165 600 722793
SGTC_356 1634-0012 32.5 µM 1.21250491759219 0.13590944078536 no 506 0.112659580661433 655 735457
SGTC_354 2783-3500 4.88 µM 1.20741516466011 0.136874035174837 no 507 0.113636149150917 613 6740761
SGTC_2316 5844804 197.44 µM 1.2057390085332 0.137192716879889 no 508 0.113959069539669 748 776813
SGTC_724 3910-0327 137 µM 1.20359519751471 0.137601050321982 no 509 0.114373038299898 632 2885483
SGTC_288 1315-0019 35.1 µM 1.20302119927178 0.137710520882738 no 510 0.114484058536675 639 6811474
SGTC_2445 5742597 35.57 µM 1.20270305124916 0.137771222345469 no 511 0.114545626371788 593 1774255
SGTC_187 1488-2104 32.728 µM 1.20123322637131 0.138051896475559 no 512 0.114830372027419 637 2852859
SGTC_1332 1480-0653 17.5 µM 1.1954412312634 0.139161716002482 no 513 0.115957342268997 614 5749438
SGTC_896 0964-0007 44.5 µM 1.19495842375786 0.139254501434973 no 514 0.116051637271459 644 6756758
SGTC_1805 st050013 60.3 µM 1.19473453301333 0.139297542803597 no 515 0.11609538285235 593 4037144
SGTC_3003 9075612 71.4286 µM 1.19329025659505 0.13957541197111 no 516 0.116377858524572 620 6501993
SGTC_14 0354-0009 295 µM 1.19176850417706 0.139868594568918 no 517 0.116676014334601 648 1713507
SGTC_34 0469-0683 81.75 µM 1.19159899545643 0.139901278207497 no 518 0.116709259546782 616 3690923
SGTC_1045 1348-1485 165 µM 1.18824023878015 0.140549963676491 no 519 0.11736938735319 677 6810614
SGTC_2192 5915882 198.485 µM 1.18672422867709 0.140843422387203 no 520 0.117668207449828 575 2876149
SGTC_2231 micatex 6.853 µM 1.18664766390556 0.140858254283439 no 521 0.117683313370564 599 20737 An antifungal of unknown mechanism.
SGTC_1942 st076330 65.2 µM 1.1861825333225 0.140948380746442 no 522 0.117775111256404 608 24208414
SGTC_3221 9128209 49.47 µM 1.18365451251517 0.141438909024132 no 523 0.118274926045197 583 16460723
SGTC_2211 7117706 200 µM 1.17891682878994 0.142361304987102 no 524 0.119215647935061 602 822771
SGTC_735 3076-0345 636 µM 1.17450581183638 0.143223751632163 no 525 0.120096242707135 702 2888990
SGTC_652 0437-0092 114 µM 1.17058583847104 0.14399314460041 no 526 0.120882646183136 614 3091274
SGTC_802 4112-3352 742 µM 1.16875534133535 0.144353378555079 no 527 0.121251108977537 708 704594
SGTC_2290 7904846 200 µM 1.16758752229384 0.144583517413784 no 528 0.121486592857683 648 2962154
SGTC_3178 9107506 49.47 µM 1.16713021650295 0.144673704708529 no 529 0.12157889343523 653 8897194
SGTC_1441 4106-0040 13 µM 1.16680587497969 0.144737692496191 no 530 0.121644386961571 621 2904180
SGTC_157 1348-1695 65.819 µM 1.16547348614341 0.145000753072962 no 531 0.121913693248167 696 5380510
SGTC_3239 9133757 49.47 µM 1.16511904104894 0.145070787206156 no 532 0.121985405185954 643 17036923
SGTC_2107 5363541 170.161 µM 1.16398973879567 0.145294075701062 no 533 0.122214085099465 667 244052
SGTC_700 3453-2283 142 µM 1.15851283639013 0.146380261402713 no 534 0.123327408183793 708 565664
SGTC_2370 9071495 200 µM 1.15494387147798 0.147090989174419 no 535 0.12405670608776 619 21791103
SGTC_685 1278-0033 54.9 µM 1.153808115842 0.147317649361472 no 536 0.124289423055457 679 3590572
SGTC_174 3553-0389 74.3 µM 1.15138987538292 0.147801031585543 no 537 0.124785938602446 593 738071
SGTC_2654 protoveratrine a 100 µM 1.15087217275371 0.147904653054307 no 538 0.124892413702518 645 5702278 A heart drug and vasodilator.
SGTC_1753 st043925 64 µM 1.15032705485168 0.148013814417522 no 539 0.125004595847011 677 670181
SGTC_2458 5808907 16.39 µM 1.14828876513853 0.148422465241781 no 540 0.125424687767507 723 2731747
SGTC_1223 0764-0573 147 µM 1.14754959931014 0.148570844722341 no 541 0.125577273183024 694 1609797
SGTC_2694 st077685 81.9 µM 1.14450845408705 0.149182364617776 no 542 0.126206416930616 656 2838096
SGTC_681 1642-0006 26.6 µM 1.14350305154464 0.149384902276327 no 543 0.126414894233986 647 4446530
SGTC_2378 9074213 121.43 µM 1.1410866367541 0.149872437843918 no 544 0.126916935848964 677 657714
SGTC_2826 7992541 19.48 µM 1.13967031983554 0.150158686510011 no 545 0.12721183841489 647 2985066
SGTC_986 1493-0483 84 µM 1.13894729993826 0.150304954869131 no 546 0.127362567778289 666 40079
SGTC_2966 9084041 48.03 µM 1.13752792348905 0.150592373603278 no 547 0.127658829125675 625 17741380
SGTC_3228 9131799 49.47 µM 1.13715847893805 0.150667244823973 no 548 0.127736020471802 659 17015818
SGTC_2403 6032726 181.2 µM 1.12596588810662 0.152947274465686 no 549 0.130089979184457 657 2881040
SGTC_424 splitomicin 100 mM 1.12283368325655 0.15358940771587 no 550 0.130754068463145 646 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1009 4106-0057 9.87 µM 1.12215626736704 0.15372851919166 no 551 0.13089800167475 716 2928005
SGTC_449 xestospongin c 11.1929 µM 1.12161997629071 0.15383870896614 no 552 0.131012027169035 716 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_120 rhodamine 6G 52.259 µM 1.12144567830847 0.153874532590868 no 553 0.131049100946093 791 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2803 7707263 71.43 µM 1.12012031921527 0.154147115455702 no 554 0.131331246457519 648 2199229
SGTC_1583 clindamycin 39.6 µM 1.1191631397106 0.154344174378102 no 555 0.131535273718943 630 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3273 9137859 49.47 µM 1.11769654159152 0.154646432640144 no 556 0.131848310166056 677 2377234
SGTC_534 k292-0788 63.4 µM 1.11714955396524 0.154759264034161 no 557 0.131965192825071 769 4146317
SGTC_2540 epiandrosterone 100 µM 1.11605686056644 0.154984825214394 no 558 0.132198898156219 826 441302 A steroid.
SGTC_3227 9130768 49.47 µM 1.11597267600679 0.155002212165148 no 559 0.132216915386047 718 17720899
SGTC_2164 5685496 200 µM 1.11286140936747 0.155645697130267 no 560 0.132883978118826 728 759046
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.11283004029599 0.155652193969545 no 561 0.132890715498562 687 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1967 st070177 51.4 µM 1.11190573765172 0.155843706299016 no 562 0.133089340745906 672 5729214
SGTC_2728 chlorpromazine 9.18 µM 1.11188073527851 0.15584888886182 no 563 0.133094716392862 586 2726 A thorazine and dopamine antagonist.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.11162844214128 0.155901191256674 no 564 0.133148969159503 761 66535 A nucleotide analog.
SGTC_1024 4507-0395 26 µM 1.11007016899366 0.15622449021615 no 565 0.133484395349128 668 4201836
SGTC_2058 5236698 133 µM 1.10992585994344 0.156254452717999 no 566 0.133515487980348 675 766665
SGTC_84 0443-0269 128.823 µM 1.10916155542277 0.156413206335943 no 567 0.133680247037963 721 6150058
SGTC_839 0122-0028 230 µM 1.10657510747084 0.156951224866113 no 568 0.134238837275406 742 759448
SGTC_766 1391-0721 126 µM 1.10433411481549 0.157418366969414 no 569 0.134724114711709 702 1020919 YIL115C NUP159
SGTC_1271 0832-2808 169 µM 1.10402346720102 0.157483194506365 no 570 0.134791479015733 729 3663794
SGTC_3091 9116372 49.47 µM 1.10198949079683 0.157908088588289 no 571 0.135233120236011 646 17169793
SGTC_1382 3002-2117 298 µM 1.10194974105039 0.157916399732486 no 572 0.135241761046733 753 1497314
SGTC_496 calpeptin 138 µM 1.10047572824009 0.15822479905059 no 573 0.135562449629833 611 73364 A calpain inhibitor.
SGTC_793 0488-0545 106 µM 1.10006826038841 0.158310120915031 no 574 0.135651190830453 713 292548
SGTC_3072 9116419 49.47 µM 1.09955958489155 0.158416677545861 no 575 0.135762029577897 619 17170162
SGTC_2499 avocadenofuran 51.48 µM 1.09952485692896 0.158423954026123 no 576 0.135769598950008 674 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1812 st052057 4.327 µM 1.09819118626321 0.158703561243473 no 577 0.136060507025391 730 3645418
SGTC_2910 7948405 25.97 µM 1.09805355042854 0.158732435329011 no 578 0.136090553231999 653 2971328
SGTC_497 capsazepine 133 µM 1.09776093832428 0.158793832725548 no 579 0.13615444619081 684 2733484 A calcium channel blocker.
SGTC_413 propylparaben 100 µM 1.0977008833037 0.158806435708 no 580 0.136167561970243 681 7175 A pharmaceutical preservative.
SGTC_2980 9014342 25.29 µM 1.09242937764518 0.159915254069946 no 581 0.137322208084988 675 2996599
SGTC_2286 7945697 125 µM 1.08938129601132 0.160558698172369 no 582 0.137992888010916 688 1245733
SGTC_2187 6125751 200 µM 1.08899840046068 0.16063964608015 no 583 0.138077295526382 722 874498
SGTC_3189 9110682 49.47 µM 1.08626584054915 0.161218110016783 no 584 0.138680697654913 713 17122418
SGTC_89 0302-0250 142.109 µM 1.08254937841971 0.162007037461335 no 585 0.139504243394152 765 4203518 YLR208W SEC13
SGTC_2831 7999036 19.48 µM 1.08193384588556 0.162137944515305 no 586 0.139640962133526 759 2988270
SGTC_2221 6807166 181.081 µM 1.08118871399269 0.162296505969479 no 587 0.13980658864287 646 674925
SGTC_2558 carylophyllene oxide 100 µM 1.08116524444619 0.16230150184594 no 588 0.13981180757769 763 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_338 4055-0136 114 µM 1.08062758782146 0.162415978259543 no 589 0.139931402818721 715 2900563
SGTC_3053 9095903 49.47 µM 1.07599443575935 0.163404633587014 no 590 0.140964872455526 733 17174018
SGTC_2881 9058953 51.95 µM 1.0742546095091 0.163776897701727 no 591 0.141354291363295 767 17122249
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.07319422670812 0.16400405361718 no 592 0.141591990244082 707 5355888
SGTC_2353 9059630 146.67 µM 1.07231912645924 0.164191672057195 no 593 0.141788359427817 715 4779114
SGTC_1175 0741-0056 27.6 µM 1.0716631939622 0.164332392929831 no 594 0.14193566907702 803 765927
SGTC_900 1112-0045 141 µM 1.06977113769955 0.164738744307325 no 595 0.142361168397209 596 56211 YIL048W NEO1
SGTC_2773 thioridazine 9.09 µM 1.06808417874611 0.165101595983745 no 596 0.142741270939936 753 5452 An antipsychotic.
SGTC_557 1315-0110 16.2 µM 1.06805008079453 0.165108935516922 no 597 0.142748960896088 734 6833801
SGTC_41 0478-0632 82.643 µM 1.06293267413857 0.16621284397005 no 598 0.143906242112127 823 3750424
SGTC_1471 k673-0312 37 µM 1.06037638786045 0.166766058165078 no 599 0.144486699934699 734 24099884
SGTC_1955 wogonin 32.4 µM 1.0585665281714 0.167158453239161 no 600 0.144898618717062 728 5281703 A flavanone.
SGTC_2812 7970281 58.44 µM 1.05625284578949 0.167660948067741 no 601 0.1454263564852 755 2233435
SGTC_968 1309-0633 340 µM 1.05444557045776 0.168054135424049 no 602 0.145839483941086 738 3761976
SGTC_1704 st028805 70.8 µM 1.05196484259716 0.168594803257628 no 603 0.146407840052828 727 2876101
SGTC_1415 3966-0071 78.1 µM 1.05124432974198 0.168752046372911 no 604 0.146573194051723 745 2893185
SGTC_585 0kpi-0023 191 µM 1.05115281425786 0.168772025250926 no 605 0.146594205352627 702 64601
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.0510882209749 0.168786127619152 no 606 0.14660903672544 779 2724 A muscle relaxant with antifungal properties.
SGTC_1983 st071813 46.9 µM 1.05055144939928 0.168903347893337 no 607 0.146732324707679 757 11838595
SGTC_3154 9100113 49.47 µM 1.04400041238571 0.170338176978221 no 608 0.148242599418459 734 25237525
SGTC_506 n9-isopropylolomoucine 153 µM 1.04327270813475 0.170498041524539 no 609 0.148411003704121 768 6610355
SGTC_2010 4012422 159 µM 1.04279996699357 0.17060194637029 no 610 0.148520473320561 760 952393
SGTC_1452 4194-0072 190 µM 1.03998484069111 0.171221528605153 no 611 0.149173471820789 832 1343545
SGTC_456 gingerol 170 µM 1.03899307459754 0.171440149086129 no 612 0.149403978562515 759 442793 A herb.
SGTC_997 3996-0078 137 µM 1.03827843818621 0.171597790883092 no 613 0.149570222007314 769 735687
SGTC_1698 5-fluorocytosine 1.055 µM 1.03575128603788 0.172155998458757 no 614 0.150159094623769 768 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2153 5569715 200 µM 1.03390379894414 0.172564811295652 no 615 0.150590569430083 750 2054701
SGTC_3246 9135460 32.98 µM 1.03365217642857 0.172620538305915 no 616 0.15064939890559 696 41446951
SGTC_834 0312-0008 75.7 µM 1.03115269542274 0.173174723035447 no 617 0.151234609914229 804 6385573 YIL048W NEO1
SGTC_2062 5245942 200 µM 1.03059028179175 0.173299577333517 no 618 0.151366497644442 802 1376160
SGTC_1816 st051957 91.6 µM 1.03054479601562 0.173309677556722 no 619 0.151377167541368 765 674121
SGTC_3145 9085516 49.47 µM 1.03004987928157 0.173419599201492 no 620 0.151493295735163 733 25236195
SGTC_862 0452-0056 10.2 µM 1.03004849872069 0.1734199058879 no 621 0.151493619755386 746 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_697 0508-1955 564 µM 1.02770634263017 0.173940704139273 no 622 0.152043991691481 820 6243113
SGTC_326 k292-0812 17.5 µM 1.02729591139542 0.174032069303049 no 623 0.152140573517127 766 3579357
SGTC_177 1327-0068 8.361 µM 1.02653756697628 0.174200962878907 no 624 0.152319132705673 776 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1156 4092-0367 4.88 µM 1.02621327069209 0.174273219841564 no 625 0.152395533704685 771 1357585
SGTC_2938 9059746 27.26 µM 1.02475601402013 0.174598148506061 no 626 0.152739162864084 739 6471769
SGTC_1693 xanthone 101.9 µM 1.02277684952774 0.175040064050221 no 627 0.153206683122977 798 7020 An insecticide.
SGTC_994 3910-0338 138 µM 1.02100483111557 0.175436328753192 no 628 0.153626074915853 807 3479481
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.02084073085102 0.175473054152649 no 629 0.153664951705861 782 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1148 3909-7663 27.7 µM 1.02077428233194 0.175487926620176 no 630 0.153680695794696 806 4084526
SGTC_2047 4141938 200 µM 1.02042916401959 0.175565183643685 no 631 0.153762484145349 728 3807862
SGTC_2762 leflunomide 42.06 µM 1.01785032514042 0.176143155950716 no 632 0.154374545847412 809 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_823 0417-1665 178 µM 1.01647041906751 0.17645291614768 no 633 0.154702713485968 794 3429856
SGTC_1197 1601-0112 267 µM 1.01576432278585 0.176611553261474 no 634 0.154870814624981 801 7350313
SGTC_537 1334-0398 209 µM 1.01521017914209 0.176736114650511 no 635 0.155002824697503 815 5846986
SGTC_1838 st055369 84.5 µM 1.0151884450932 0.176741001200107 no 636 0.155008003773956 756 676036
SGTC_1980 st071811 45.7 µM 1.01457968158725 0.1768779065354 no 637 0.155153114415526 789 4974850
SGTC_3267 9137951 49.47 µM 1.0138834173639 0.177034572124289 no 638 0.155319192467249 767 16643986
SGTC_2371 9071574 200 µM 1.00984620002271 0.177944708815812 no 639 0.156284490836203 743 45596039
SGTC_222 nsc-310342 10.666 µM 1.00922541445834 0.17808491790982 no 640 0.156433270420307 713 432556
SGTC_1563 conessine 56.1 µM 1.00446574719881 0.179162237617678 no 641 0.157577086636973 907 441082 An anti-amoebic, histamine inhibitor.
SGTC_1627 st003713 25.6 µM 1.00272861763982 0.179556444570771 no 642 0.157995909121976 855 16195070 YER133W GLC7
SGTC_1499 4480-0877 67.3 µM 1.00027255784786 0.18011472787271 no 643 0.158589311899272 762 2861909
SGTC_2555 cholic acid 100 µM 0.999702164105284 0.180244538983856 no 644 0.158727332230843 796 6708657 Influences liver metabolism.
SGTC_3050 9093513 49.47 µM 0.998106692997461 0.180607950538692 no 645 0.159113812483849 813 25236664
SGTC_2385 9074692 200 µM 0.996284227980356 0.181023627857862 no 646 0.159556032415615 799 17046906
SGTC_2332 7982454 138.89 µM 0.995679584765342 0.181161670358151 no 647 0.159702926240275 816 2981748
SGTC_2017 5132927 60.65 µM 0.994500778592998 0.181430986119302 no 648 0.159989563272239 801 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_691 1548-0686 185 µM 0.992835587816501 0.181811850514625 no 649 0.160395041918747 800 46495133
SGTC_2729 fluphenazine 10.66 µM 0.986488706876969 0.183268097690067 no 650 0.161946677131695 838 3372 An atypical antipsychotic.
SGTC_277 nystatin 15.5 µM 0.986176576172935 0.183339901039951 no 651 0.162023235807444 843 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_149 3970-0822 46.1 µM 0.986102696778804 0.183356899012678 no 652 0.162041360218922 928 3114250 YBL034C STU1
SGTC_2811 7967822 32.47 µM 0.985528343864374 0.183489078099592 no 653 0.162182307987657 803 2232244
SGTC_274 sirtinol 40.1 µM 0.985044652897862 0.183600438697258 no 654 0.162301068970818 813 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_26 0302-0163 425.158 µM 0.984970124283222 0.183617601229879 no 655 0.162319373066265 824 3100915
SGTC_1526 st051518 75 µM 0.984799297312014 0.183656943227307 no 656 0.162361332936877 742 673993
SGTC_2626 ethyl orsellinate 100 µM 0.984081311156496 0.183822355156616 no 657 0.162537767559323 774 75653 A natural product.
SGTC_2271 7849410 118.62 µM 0.98371497113763 0.183906789474235 no 658 0.162627838321335 824 972430
SGTC_2185 6113692 200 µM 0.9818994014427 0.184325599685052 no 659 0.163074705342411 764 874150
SGTC_440 fluspirilene 35.1 µM 0.980752368902804 0.184590499376178 no 660 0.163357436000035 826 3396 An atypical antipsychotic.
SGTC_2751 anetholtrithion 17.25 µM 0.979775354935168 0.184816320989778 no 661 0.1635985099648 806 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1105 epirubicin 18.1 µM 0.978859346964467 0.185028197907714 no 662 0.163824740669241 798 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2148 5546263 113.568 µM 0.977353760750023 0.185376774732636 no 663 0.164197023126535 815 792097
SGTC_1905 st060207 84.5 µM 0.976727168050129 0.185521964994817 no 664 0.164352120658827 820 1948547
SGTC_469 w7 172 µM 0.975653294355811 0.185770960567105 no 665 0.164618152351184 805 45115570 A P450 inhibitor.
SGTC_3312 9133330 71.43 µM 0.97134227913086 0.186772626463725 no 666 0.16568893077547 888 17617324
SGTC_3342 9147791 14.508 µM 0.970294386643824 0.187016608780702 no 667 0.165949887246915 826 1838168
SGTC_2344 7990960 76.95 µM 0.96973329310753 0.187147330011709 no 668 0.166089725394372 791 140813
SGTC_3016 9080866 49.47 µM 0.966793506861061 0.187833152427783 no 669 0.166823635530543 852 17066299
SGTC_569 4130-2812 160 µM 0.966176504313867 0.187977289702375 no 670 0.166977933868065 732 743552
SGTC_2051 5263410 176 µM 0.963974480093846 0.18849225861359 no 671 0.167529360290593 865 227584
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.963908386735058 0.188507728748533 no 672 0.167545929368688 885 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_81 0411-0046 9.971 µM 0.962174350435786 0.188913885467559 no 673 0.167981015584996 771 12925265
SGTC_2243 6634756 200 µM 0.961685025179771 0.189028595727286 no 674 0.168103923389507 808 885676
SGTC_1527 coumarin 137 µM 0.957249344331214 0.19007038809194 no 675 0.169220708235165 796 323 A hepatotoxic, DNA x-linker.
SGTC_2930 9013230 14.89 µM 0.954550405445231 0.190706001434153 no 676 0.169902553757102 885 2995857
SGTC_2698 st077697 67.5 µM 0.95408543935312 0.190815634809254 no 677 0.170020197931813 792 3154499
SGTC_1802 st050112 57.9 µM 0.953263258061543 0.191009589829189 no 678 0.170228351268279 859 4662563
SGTC_2866 9034245 58.44 µM 0.953099645559947 0.191048200926556 no 679 0.170269792854035 843 6462273
SGTC_3237 9133362 49.47 µM 0.951014112772989 0.191540787413683 no 680 0.170798605886797 854 43845137
SGTC_269 exalamide 29 µM 0.949877088003274 0.19180967117355 no 681 0.171087355037518 848 3316 A derivative of salicylamide.
SGTC_295 k015-0027 31 µM 0.949123626669647 0.191987977049246 no 682 0.171278869571505 843 3887424
SGTC_3140 9094243 49.47 µM 0.948919318436204 0.192036343867189 no 683 0.171330824178279 932 19291112
SGTC_2925 9010536 32.5 µM 0.948892959079762 0.192042584580632 no 684 0.171337527970249 914 2994177
SGTC_1977 st070720 65.3 µM 0.948565288693918 0.192120172592607 no 685 0.171420876100213 809 682188
SGTC_11 0438-0307 1.3 µM 0.946568866528793 0.192593313235969 no 686 0.171929257374821 842 4011476
SGTC_3159 9100096 49.47 µM 0.945434929979717 0.192862366571047 no 687 0.172218438202843 835 25236875
SGTC_899 1083-0020 478 µM 0.94451434719637 0.193080965439587 no 688 0.17245343687386 875 767123
SGTC_2911 7942208 15.64 µM 0.93855811666007 0.194498966930281 no 689 0.173978832619339 812 1243384
SGTC_74 000s-0487 160.283 µM 0.937467628346748 0.194759264579186 no 690 0.174259033914209 926 677548
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.932059706503611 0.196053254398819 no 691 0.175652835046746 896 23665772 A membrane-active detergent.
SGTC_2954 9074818 52.69 µM 0.930207096960522 0.196497737228815 no 692 0.176131934033916 846 16648742
SGTC_3332 9141069 11.198 µM 0.930121399404904 0.196518312771904 no 693 0.176154116075084 813 17332883
SGTC_133 0724-0033 378.92 µM 0.927749001902647 0.19708843141453 no 694 0.176768891758139 845 280309
SGTC_879 0831-1030 162 µM 0.926536565467867 0.197380182080612 no 695 0.177083601822397 892 1549252
SGTC_2514 salinomycin 42.74 µM 0.92323434118579 0.198176125427745 no 696 0.177942548113814 959 23682228 A polyether potassium ionophore.
SGTC_2114 5491910 81.25 µM 0.922692842722547 0.198306828828514 no 697 0.178083648387346 889 2849228
SGTC_1901 st060216 58.6 µM 0.92140227377338 0.198618547711632 no 698 0.178420221046706 898 688792
SGTC_1839 st053978 48 µM 0.920277093481814 0.198890560268048 no 699 0.178713988111965 891 3788398
SGTC_3009 9080819 71.4286 µM 0.920195204200682 0.198910365779389 no 700 0.178735380010703 886 17027216
SGTC_2194 5927483 104.545 µM 0.91699226918211 0.199685950808453 no 701 0.179573345598717 953 760979
SGTC_93 0109-0045 59.227 µM 0.914389238956715 0.200317608201395 no 702 0.180256177123238 1046 88733
SGTC_2754 granisetron 64.02 µM 0.912490444663763 0.200779130393016 no 703 0.180755298671946 882 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1653 st012112 65 µM 0.911965981735161 0.200906719091337 no 704 0.180893312799601 855 720429
SGTC_1111 tnp00062 510.699 nM 0.911342400037789 0.201058484195482 no 705 0.181057496277309 945 676306
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.910848616564409 0.201178708237452 no 706 0.181187571258237 872 4330530
SGTC_1854 st056233 32.9 µM 0.909474993190022 0.20151337817692 no 707 0.181549725978332 875 5393174
SGTC_357 1325-0123 420 µM 0.909007408993582 0.201627376567909 no 708 0.181673107470302 894 1098503
SGTC_3120 9124077 49.47 µM 0.908442136581353 0.201765243200153 no 709 0.181822335997213 928 18774327 YGL155W CDC43
SGTC_2087 5276107 200 µM 0.907859681848796 0.201907359536297 no 710 0.181976180734966 886 144405
SGTC_2853 9015042 58.44 µM 0.904650139618806 0.202691547727767 no 711 0.182825381819501 852 6457456
SGTC_1235 benzylparaben 21.5 µM 0.904584193258397 0.202707679476655 no 712 0.182842856221172 856 7180
SGTC_3130 9127414 49.47 µM 0.903120733749337 0.203065867228062 no 713 0.183230910510632 897 1494646
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.902185802794627 0.203294893136776 no 714 0.183479087629446 938 688798
SGTC_2423 st077119 87.2 µM 0.897293552666104 0.204495837552724 no 715 0.184781147960127 894 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_770 0389-1121 67.2 µM 0.892113406708853 0.205772045387416 no 716 0.186166074804641 981 6753108
SGTC_2112 5488546 200 µM 0.890721813002081 0.206115689343539 no 717 0.1865392148081 908 600757
SGTC_2857 9024691 58.44 µM 0.886447926469516 0.207173219756623 no 718 0.187688101500072 894 16478292
SGTC_2337 9009472 200 µM 0.885577854151344 0.207388902953468 no 719 0.187922524780416 935 5742383
SGTC_1641 st009299 47.1 µM 0.883302754295794 0.207953506996077 no 720 0.188536358033777 890 4046054
SGTC_78 0336-0123 156.75 µM 0.882342298170661 0.208192132400196 no 721 0.188795864586564 849 6765896
SGTC_219 mitoxanthrone 164.414 µM 0.88021217766429 0.208721937219704 no 722 0.189372188857347 872 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_40 0327-0103 19.753 µM 0.879948762416867 0.208787509175731 no 723 0.189443533504866 895 409036
SGTC_2855 9016525 58.44 µM 0.879302496057036 0.20894843567258 no 724 0.189618641444129 962 43811474
SGTC_1317 1273-0028 910 nM 0.876882289161266 0.209551739103917 no 725 0.190275288452126 960 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1954 st077032 68.9 µM 0.876597232832959 0.209622864656113 no 726 0.190352721368448 844 698907
SGTC_852 0418-0143 439 µM 0.876505222743836 0.209645825494588 no 727 0.190377719189788 1007 5369229
SGTC_3026 9090633 49.47 µM 0.874172421471764 0.210228462935838 no 728 0.191012181239574 965 25236842
SGTC_370 0180-0345 38.7 µM 0.873927764509065 0.210289623192046 no 729 0.191078796704777 861 3989527
SGTC_842 0271-0008 11.1 µM 0.872744298193185 0.210585617969616 no 730 0.191401233298477 980 1221709
SGTC_1328 1441-0025 69.2 µM 0.86838944961586 0.211676904762773 no 731 0.192590584291536 897 4562601
SGTC_2985 9022375 71.43 µM 0.86584708698726 0.212315525823589 no 732 0.193287011620817 955 4939335
SGTC_3223 9129970 49.47 µM 0.865810005581063 0.212324848698428 no 733 0.19329718065862 985 17248386
SGTC_2242 6630449 61.2675 µM 0.86475462729804 0.212590288425746 no 734 0.193586739710569 852 691249 YDR170C SEC7
SGTC_2786 7743617 45.45 µM 0.864255721626264 0.212715836351258 no 735 0.193723714091688 858 583674
SGTC_322 k048-0136 19.3 µM 0.863661647932873 0.212865389437207 no 736 0.193886893870934 928 6823282
SGTC_602 3130-1533 38.1 µM 0.862672640085063 0.213114499974067 no 737 0.194158739662797 997 720941
SGTC_2060 5238662 140 µM 0.859981990563018 0.213793078722772 no 738 0.194899485019701 896 790130
SGTC_3338 9144300 39.5675 µM 0.859461958363592 0.213924375203895 no 739 0.195042849651676 948 4901274
SGTC_182 3448-4371 550.524 µM 0.859165498142158 0.213999245773193 no 740 0.195124607717798 1020 3491403
SGTC_3147 9097027 49.47 µM 0.857069713865367 0.214528967725594 no 741 0.195703178922694 995 25236841
SGTC_2005 4024620 188 µM 0.855287368410691 0.214980065370345 no 742 0.196196039353127 956 236743
SGTC_221 trifluoperazine 10.304 µM 0.855281931475565 0.21498144225814 no 743 0.196197543944062 1075 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2974 9094440 9.66 µM 0.854432870756595 0.215196527222132 no 744 0.196432594723276 977 25236134
SGTC_2063 5246145 200 µM 0.854190567045097 0.215257930756552 no 745 0.196499704460938 996 711240
SGTC_2580 diallyl disulphide 81.36 µM 0.854057565603277 0.215291639715431 no 746 0.196536547160075 906 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1617 st002906 78 µM 0.852589759632291 0.215663855702463 no 747 0.196943421680339 976 5150859
SGTC_643 k048-0106 28.4 µM 0.850544161203197 0.216183213951798 no 748 0.197511309518316 955 6763920
SGTC_1360 1598-0022 39.8 µM 0.849002611120617 0.216575077145309 no 749 0.197939919671385 1030 761525
SGTC_307 1501-1223 22.3 µM 0.847822766405334 0.216875271974454 no 750 0.198268341063835 956 2830329
SGTC_3158 9100007 49.47 µM 0.847633827766359 0.216923367078432 no 751 0.198320964529437 947 19297233
SGTC_1272 0839-0021 27 µM 0.847205918497356 0.217032315924736 no 752 0.198440177603309 977 5027250
SGTC_2343 7990716 14.84 µM 0.845997960063796 0.217340041595051 no 753 0.198776941134561 975 6456862
SGTC_1546 5-methoxyflavanone 78.7 µM 0.840605847780857 0.218716743249544 no 754 0.200284390806094 1019 147795
SGTC_1956 st077085 54 µM 0.839707246045558 0.218946659087499 no 755 0.200536275110601 1004 24208685
SGTC_1153 4055-0057 267 µM 0.838910944309916 0.219150516627014 no 756 0.200759642914865 986 882706
SGTC_355 1311-2252 105 µM 0.835708894188123 0.219971359579463 no 757 0.201659345218952 947 5338538
SGTC_1911 st060208 74.3 µM 0.83543228856539 0.220042349888993 no 758 0.20173717818786 1008 688783
SGTC_2166 5933061 31.504 µM 0.832748178943846 0.220731903777231 no 759 0.202493383152201 1091 2877375
SGTC_1743 st037606 46.3785 µM 0.832006980128768 0.220922537278976 no 760 0.202702502292341 970 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3256 9138902 49.47 µM 0.830977614339748 0.221187442495519 no 761 0.202993137786828 1041 17228773
SGTC_2551 apiole 73.87 µM 0.828711006504409 0.221771389621946 no 762 0.203633978069924 879 10659 A possible DNA adduct former.
SGTC_1037 k284-1091 78.7 µM 0.822913253242325 0.223269067968203 no 763 0.205278662711086 950 3334711
SGTC_1294 1000-1494 117 µM 0.822213878953267 0.223450118941306 no 764 0.205477590544461 986 712797 YDL207W GLE1
SGTC_3075 9116269 49.47 µM 0.821968833295711 0.223513575049151 no 765 0.205547317635135 1008 17015205 YNL244C SUI1
SGTC_188 3229-0966 278.469 µM 0.821788340391716 0.22356032137206 no 766 0.205598685394428 1125 5722370
SGTC_501 nsc-95397 161 µM 0.820222703335162 0.223966042989771 no 767 0.206044580834429 990 262093
SGTC_1654 st012436 41.8 µM 0.81995416026219 0.224035675667867 no 768 0.206121119823317 976 4323132
SGTC_1840 st055363 71 µM 0.81969245245818 0.224103547805985 no 769 0.206195726870467 935 676033
SGTC_414 piperonyl butoxide 100 µM 0.819600092872881 0.224127503423777 no 770 0.206222060345768 995 5794 A potent inhibitor of cytochrome P450.
SGTC_1059 3448-6867 171 µM 0.818983183498918 0.224287550589091 no 771 0.206398004070621 1034 3934407
SGTC_1665 st014639 11.4 µM 0.818273560645527 0.224471730986636 no 772 0.206600499818984 1070 981133 YIL048W NEO1
SGTC_1412 3909-8563 178 µM 0.816302242820683 0.224983830510089 no 773 0.207163645977236 1095 23767530
SGTC_148 3253-0744 288.01 µM 0.812802086898359 0.225894713765009 no 774 0.208165769425689 1051 6893655
SGTC_237 nikkomycin 200 µM 0.812653120211891 0.225933527178949 no 775 0.208208483184464 1026 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.811066436850671 0.226347172958866 no 776 0.208663759472591 1020 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2427 5545055 42.75 µM 0.809136842601381 0.22685079096565 no 777 0.209218219161687 1062 5372858
SGTC_764 1951-2361 146 µM 0.808435542500147 0.227033984575476 no 778 0.209419949088524 970 5438930
SGTC_1579 chlormadinone acetate 49.4 µM 0.807139623362672 0.227372723956991 no 779 0.209793022992482 1047 45114258 A steroidal progestin.
SGTC_1461 k072-0203 53.8 µM 0.806739655026978 0.227477328867886 no 780 0.209908246185587 980 5418714
SGTC_943 3253-1379 105 µM 0.805591483699796 0.227777764073221 no 781 0.210239218851088 1000 668464
SGTC_1242 0402-0103 60.1 µM 0.805573807928796 0.22778239093248 no 782 0.210244316475344 986 432868
SGTC_1631 benzylvanillin 81.9 µM 0.805414581833617 0.227824072784802 no 783 0.210290239939672 999 75506
SGTC_511 blebbistatin 171 µM 0.805337398611172 0.227844279181215 no 784 0.210312502989181 1020 3476986 A myosin inhibitor.
SGTC_811 0416-0114 265 µM 0.804597581405897 0.228038012836486 no 785 0.210525969137575 1004 6612453
SGTC_720 r052-1644 49.9 µM 0.803334155032028 0.228369076527739 no 786 0.210890810829302 952 1422863 YOR257W CDC31
SGTC_358 0075-0058 9.45 µM 0.802534197647749 0.228578834048075 no 787 0.211122007391697 1061 1069125
SGTC_253 dyclonine 31.25 µM 0.798476703874787 0.229644417786547 no 788 0.212296953425378 1094 3180 An oral anasthetic.
SGTC_2446 5162541 200 µM 0.795256615006124 0.230492057915004 no 789 0.213232122470394 979 1549321
SGTC_2388 9080168 200 µM 0.793339862990662 0.230997443290007 no 790 0.213789918823957 991 15943073
SGTC_1681 tripelennamine 100 µM 0.793161891858315 0.231044399872377 no 791 0.213841753500071 1011 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1597 7-benzyloxygramine 47.5 µM 0.793156727691115 0.231045762485483 no 792 0.213843257689958 1084 260807
SGTC_2424 5537928 59.2 µM 0.792537314599369 0.231209232868442 no 793 0.214023721573194 1102 5382802
SGTC_967 1306-0166 352 µM 0.792531329077428 0.231210812832642 no 794 0.214025465866837 1040 4437607
SGTC_1205 4161-2785 76 µM 0.792441655914574 0.231234484068773 no 795 0.214051599303243 936 3498106
SGTC_3006 9075424 71.4286 µM 0.789904209501807 0.231904859907028 no 796 0.214791856409489 1024 7465181
SGTC_2486 5283202 22.39 µM 0.787439961732885 0.232556931857188 no 797 0.215512180630063 1002 1377751
SGTC_1379 2144-0755 36.5 µM 0.786315346281347 0.232854858144931 no 798 0.2158413820101 1106 5392327
SGTC_2607 solasodine 47.35 µM 0.785027911142342 0.233196177794582 no 799 0.216218602073645 1058 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_479 n-linoleoylglycine 10 µM 0.784105692099923 0.233440843430444 no 800 0.216489047868238 1056 6433346 An anti-infammatory.
SGTC_1372 2752-0194 270 µM 0.78317740279562 0.233687263253793 no 801 0.216761471370767 997 823334
SGTC_1453 4237-0541 195 µM 0.783123667767779 0.233701531945098 no 802 0.216777246966352 1078 739892
SGTC_797 k781-0471 270 µM 0.781218636812572 0.234207701997675 no 803 0.217336957132465 1074 23738129
SGTC_305 1682-2595 20.8 µM 0.77772628057186 0.235137201390985 no 804 0.218365197807643 1080 226033
SGTC_3104 9120930 49.47 µM 0.777330461037968 0.235242678145792 no 805 0.218481913928073 1019 17014836
SGTC_2303 7774051 200 µM 0.772533883584277 0.23652292941913 no 806 0.219899143246129 1057 2953184
SGTC_2197 6588183 93.1375 µM 0.772474901752287 0.236538696048122 no 807 0.219916603191341 1056 884136
SGTC_2102 5377816 72.7585 µM 0.769500617261869 0.237334511364599 no 808 0.22079808911781 1114 1379702
SGTC_3196 9111891 49.47 µM 0.764959067072173 0.238552503951665 no 809 0.222147959673479 1132 18891510
SGTC_734 2023-0417 80 µM 0.764117099730657 0.238778685469455 no 810 0.222398731493161 1056 3935732
SGTC_2369 9071472 200 µM 0.763159160867436 0.23903616354701 no 811 0.222684240567516 1092 17296037
SGTC_3318 9139014 38.6185 µM 0.761368809844063 0.23951778685963 no 812 0.223218405792512 1057 16643984
SGTC_1755 st041960 45.185 µM 0.761232845636889 0.239554384298947 no 813 0.22325900155382 1088 2257073
SGTC_3320 9137005 35.139 µM 0.758863751865956 0.240192562228766 no 814 0.223967032247694 1041 4908713
SGTC_2789 5281112 71.43 µM 0.758581296402655 0.240268710833999 no 815 0.224051532322294 1087 765948
SGTC_2724 maprotiline 69.64 µM 0.755558084103935 0.241084577324824 no 816 0.224957097510778 1107 4011 A tricyclic antidepressant.
SGTC_1356 1502-0781 85.8 µM 0.755360020453673 0.241138080773643 no 817 0.225016497302575 1042 567702
SGTC_2357 9067248 200 µM 0.753869836396481 0.241540834972286 no 818 0.22546369219542 1082 9150235
SGTC_1569 carminic acid 40.6 µM 0.753206730598046 0.241720170907215 no 819 0.225662847717861 1130 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2411 st077133 39.94 µM 0.752779371726258 0.241835787738346 no 820 0.225791252329314 1129 1403142 YNL221C POP1
SGTC_3271 9137798 49.47 µM 0.752127451030218 0.242012214870201 no 821 0.225987208558469 1040 6498326
SGTC_3336 9143619 71.43 µM 0.751891385147365 0.242076117806745 no 822 0.226058189635019 1136 45595730
SGTC_631 k072-0230 41.5 µM 0.751389994017449 0.242211874527229 no 823 0.226208991390112 1122 5773147
SGTC_2822 7994718 71.43 µM 0.751316953245181 0.242231654498459 no 824 0.226230964364361 1036 1018011
SGTC_2617 dihydrotanshinone i 20.83 µM 0.750888397391756 0.24234772817131 no 825 0.226359911810225 1148 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.750882187869325 0.24234941023209 no 826 0.226361780487975 1079 688662
SGTC_432 NS 1619 61.3 µM 0.750558025502106 0.242437229441801 no 827 0.226459345178373 1029 4552 A K+/calcium channel activator.
SGTC_965 1291-5240 308 µM 0.750356735742177 0.242491769763252 no 828 0.226519940263583 1096 2834598
SGTC_3210 9128157 49.47 µM 0.749500854345324 0.242723748677835 no 829 0.226777691950095 1020 17590849
SGTC_3344 9148862 3.898 µM 0.749394000087423 0.242752718991194 no 830 0.226809883100216 1122 4905352
SGTC_2328 6201408 200 µM 0.749372911949985 0.242758436625566 no 831 0.226816236463733 1039 2890418
SGTC_779 1360-0071 233 µM 0.749209592715598 0.242802719897129 no 832 0.226865444136137 1184 7566
SGTC_2075 5212009 200 µM 0.747815288312958 0.243180957150569 no 833 0.227285789609239 1031 780898
SGTC_2630 antimycin a 100 µM 0.747396450096268 0.243294638872579 no 834 0.227412143790176 1166 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2472 5377652 49.4 µM 0.746976160230235 0.243408743470201 no 835 0.227538975667224 1111 1610903
SGTC_2890 9046729 58.44 µM 0.746538830190927 0.243527504999171 no 836 0.227670992077308 1047 903329
SGTC_2705 st078069 42.8 µM 0.74630853094622 0.243590057737148 no 837 0.227740529623354 1083 1530061
SGTC_1274 0865-0114 173 µM 0.744932542456778 0.24396397763904 no 838 0.22815625051129 1124 870624
SGTC_2997 9067075 71.4286 µM 0.744125936968193 0.244183313652405 no 839 0.228400144643641 1122 27209819
SGTC_1199 1638-0010 4.46 µM 0.743934512669335 0.244235382267478 no 840 0.228458047308147 1099 3111136
SGTC_982 1491-0518 27.5 µM 0.743828533488306 0.244264211846362 no 841 0.228490107793175 1067 3091256
SGTC_477 mead ethanolamide 10 µM 0.742801093530499 0.244543802019229 no 842 0.228801056665365 988 16061185
SGTC_1947 st076332 61.6 µM 0.741913320689855 0.244785524297762 no 843 0.229069927270148 1121 24208416
SGTC_2571 chrysanthemic acid 100 µM 0.741097364142118 0.245007805860528 no 844 0.229317203851103 1076 2743 An insecticide.
SGTC_1380 2291-0730 164 µM 0.738658806487554 0.245672760496638 no 845 0.23005710277121 1132 2999191
SGTC_1804 st050076 49.1 µM 0.737630948937051 0.245953330437367 no 846 0.230369371579959 1128 3895976
SGTC_1158 4092-0494 91.8 µM 0.737404086217381 0.24601527935157 no 847 0.230438325640723 1169 1148199
SGTC_2533 agelasine 13.65 µM 0.737315273453594 0.246039533541545 no 848 0.230465323084698 1165 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1130 3454-2858 15.9 µM 0.7371984705635 0.246071433606358 no 849 0.230500831702887 1065 715628 YIL048W NEO1
SGTC_2090 5301565 104.445 µM 0.735526797909975 0.246528227517529 no 850 0.23100936283754 1140 2056344
SGTC_991 3996-0057 64.7 µM 0.735086307688307 0.246648669518638 no 851 0.231143466331745 1087 715343
SGTC_934 2950-0684 338 µM 0.734959214353024 0.246683426148675 no 852 0.231182166888133 1146 1121253
SGTC_3160 9100216 49.47 µM 0.73412963056104 0.246910359562273 no 853 0.231434868102232 1111 17191039
SGTC_2653 dihydrofissinolide 100 µM 0.729610727000704 0.248148469244931 no 854 0.232814081702228 1160 6857746
SGTC_1249 0481-0015 10.2 µM 0.726455434291138 0.249014929948581 no 855 0.233779809233461 1125 4227577
SGTC_1401 3807-4679 7.6 µM 0.726115354883609 0.249108413629216 no 856 0.233884028328808 1118 3291456
SGTC_2995 9067767 71.4286 µM 0.726069084205911 0.249121134316746 no 857 0.233898210206924 1121 11673567
SGTC_1638 st008370 60.6 µM 0.726056450930153 0.249124607504083 no 858 0.233902082365648 1177 24207134
SGTC_554 4483-2211 187 µM 0.726001106945329 0.249139823182587 no 859 0.233919045977163 1111 747107
SGTC_1292 0kpi-0043 232 µM 0.724752592378649 0.249483207633546 no 860 0.234301912117864 1120 3333905
SGTC_389 tpck 16.7 µM 0.724407814240765 0.249578077776871 no 861 0.234407701944739 1132 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_530 4358-1714 28 µM 0.723801727029713 0.249744896923307 no 862 0.234593734463118 1145 1564641
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.723114784826698 0.249934042118251 no 863 0.234804683314283 1142 6708514
SGTC_2940 9060638 45.86 µM 0.722876466673713 0.249999679274407 no 864 0.23487789145937 1128 4027022
SGTC_2658 polymyxin b sulfate 77.05 µM 0.720549218389027 0.250641126291986 no 865 0.235593453639792 1144 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2375 9072683 200 µM 0.71999548143204 0.25079387814024 no 866 0.235763888828356 1219 16798029
SGTC_613 3914-0030 117 µM 0.71995938330119 0.250803837749396 no 867 0.235775001864006 952 1145395
SGTC_2402 5553605 200 µM 0.719612995703064 0.250899418026217 no 868 0.235881654137173 1179 6758546
SGTC_1610 st001799 48.1 µM 0.717385889281161 0.251514413642853 no 869 0.236568011957434 1065 621897
SGTC_1515 3460-0031 42.1 µM 0.71567879199902 0.251986352070923 no 870 0.237094854551751 1104 2876596
SGTC_1981 st071826 47 µM 0.715616049072736 0.252003706669946 no 871 0.237114230484085 1131 11838600
SGTC_123 0083-0120 66.675 µM 0.715189789938405 0.252121626000039 no 872 0.237245888563223 1127 16001701
SGTC_2749 bexarotene 57.39 µM 0.714064161785908 0.25243315699649 no 873 0.237593752737658 1164 82146 An retinoic acid receptor inhibitor.
SGTC_421 streptovitacin 30 mM 0.712979725179363 0.252733479503881 no 874 0.237929151626114 1165 91467 include heat shock
SGTC_1735 st034310 56.75 µM 0.712767639689533 0.252792236180443 no 875 0.237994776609623 1146 871153
SGTC_901 1112-0062 60.1 µM 0.711979331813827 0.253010693929155 no 876 0.238238787335101 1194 1908457
SGTC_2768 sulfasalazine 50.2 µM 0.710196624626713 0.253505088051466 no 877 0.238791106857915 1201 5384001 An antioxidant and salicylic acid derivative.
SGTC_1834 st055981 52.8 µM 0.70888808128957 0.253868306169351 no 878 0.239196965975021 1184 471719 YDL150W RPC53
SGTC_1895 st058434 18.3 µM 0.707319809837807 0.25430397775819 no 879 0.239683878809546 1189 5393175
SGTC_2895 9054447 58.44 µM 0.703373967460805 0.255401878606411 no 880 0.240911362735857 1210 2697450
SGTC_486 niguldipine 82 µM 0.702211984645033 0.255725663041981 no 881 0.241273486340755 1184 1236 A calcium channel blocker.
SGTC_3165 9101544 49.47 µM 0.699209866653705 0.256563188932578 no 882 0.242210442685452 1174 5002184
SGTC_2447 5741742 33.78 µM 0.69865296866021 0.256718708354951 no 883 0.242384466296292 1210 1776504
SGTC_2081 5214970 32.255 µM 0.698285682227699 0.256821303674513 no 884 0.242499275744082 1155 2063512
SGTC_1052 3253-3998 198 µM 0.697183085585513 0.257129423739049 no 885 0.242844111442233 1190 5450317
SGTC_3123 9126162 49.47 µM 0.696635419634539 0.25728254012979 no 886 0.243015491856374 1257 25239884
SGTC_516 3992-2719 87.3 µM 0.696173357918043 0.257411760147298 no 887 0.243160135110357 1167 5350887 YDR037W KRS1
SGTC_657 3534-0529 86.7 µM 0.694802530446188 0.257795323606556 no 888 0.243589531087422 1210 1049549
SGTC_960 1222-0186 7.7 µM 0.694233280298069 0.257954689382706 no 889 0.243767962425128 1190 3126296
SGTC_1732 st034308 51.822 µM 0.693899371138363 0.258048193490031 no 890 0.243872659000795 1107 830119
SGTC_2596 sinensetin 100 µM 0.693127661505988 0.258264361480179 no 891 0.244114719891904 1180 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1354 1498-1681 81 µM 0.692906133035395 0.258326432418446 no 892 0.244184230291261 1233 5754243
SGTC_286 k060-0067 22.9 µM 0.691369149479921 0.258757298705264 no 893 0.244666793156369 1177 5985051
SGTC_1861 st057647 17.4 µM 0.691334897810426 0.258766904792899 no 894 0.2446775529133 1228 688668
SGTC_3353 9151644 39.2805 µM 0.691324240123812 0.258769893843145 no 895 0.244680900951492 1200 4909158
SGTC_2474 5321570 43.32 µM 0.690315933584463 0.259052763859951 no 896 0.24499776498242 1211 2841384
SGTC_546 peri-Naphthalide 147 µM 0.689915086455778 0.259165261796732 no 897 0.245123793962873 1162 223824 A penicillin ester.
SGTC_2690 usnic acid 100 µM 0.688455476705931 0.259575115270571 no 898 0.245582999373823 1254 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3300 9124615 50.48 µM 0.687012501496662 0.25998062653248 no 899 0.24603742523556 1230 24824903
SGTC_824 1304-0008 100 µM 0.684150540034396 0.260785873052507 no 900 0.246940055276783 1224 768245
SGTC_1850 st056238 17 µM 0.683264202751538 0.261035514457928 no 901 0.247219954920354 1225 5393177
SGTC_334 1502-1024 68.5 µM 0.682658881959775 0.261206076716768 no 902 0.247411208803457 1245 3296216
SGTC_1112 tnp00069 1.16933 µM 0.680272966487972 0.261878917413217 no 903 0.248165819220463 1252 145826
SGTC_2261 9010538 184.68 µM 0.679566828175647 0.262078222448883 no 904 0.248389389776309 1154 6457250
SGTC_2799 7812892 81.82 µM 0.678157258937755 0.262476300724046 no 905 0.248835994544824 1215 20205235
SGTC_2854 9024559 71.43 µM 0.677969637872131 0.262529310365648 no 906 0.248895472204021 1200 3163529
SGTC_2561 acetosyringone 100 µM 0.677683624183895 0.262610129974403 no 907 0.248986155816701 1231 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1038 k292-0204 154 µM 0.675829398122755 0.263134391956813 no 908 0.249574483673279 1189 4454212
SGTC_3274 9138298 49.47 µM 0.674497102384454 0.263511413767933 no 909 0.24999766365257 1211 17015756
SGTC_752 1896-0090 130 µM 0.674490759476595 0.2635132093849 no 910 0.249999679274407 1226 772567
SGTC_2149 5554786 194.827 µM 0.673116483378099 0.263902401085007 no 911 0.25043659405297 1261 745063 YPR165W RHO1
SGTC_2008 4012253 172 µM 0.672251387044298 0.264147544489331 no 912 0.250711835989657 1246 603940
SGTC_841 0251-0215 91.2 µM 0.671985338219023 0.264222958385156 no 913 0.250796515169774 1265 3888614
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.671806907898125 0.264273542182138 no 914 0.250853315232603 1259 23847180
SGTC_850 0388-0143 75.9 µM 0.670686581191117 0.264591259914835 no 915 0.251210106514573 1206 67273
SGTC_2244 6635614 200 µM 0.668431329680569 0.26523142406338 no 916 0.251929151219849 1153 836499
SGTC_2591 skatole 100 µM 0.667992858941098 0.2653559773707 no 917 0.252069075419059 1248 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_442 cape 100 µM 0.663804320644028 0.266547280425041 no 918 0.253407779994933 1229 5281787
SGTC_741 4582-0002 126 µM 0.662260483585205 0.266987059387823 no 919 0.253902148707838 1233 2912688
SGTC_2733 amorolfine 100 µM 0.66079370479452 0.267405226667103 no 920 0.2543723102511 1268 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_728 3030-5151 22.5 µM 0.65991238348238 0.267656643339672 no 921 0.254655028453276 1268 3125388
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.658763077083975 0.267984687664521 no 922 0.255023960407808 1240 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1171 0368-0077 21.4 µM 0.656257707815954 0.268700491367484 no 923 0.255829162083841 1231 3239779
SGTC_1221 2958-7315 257 µM 0.654814498181914 0.269113263318126 no 924 0.256293597472966 1270 4562705
SGTC_2080 5212524 12.4 µM 0.6527773275669 0.269696454902442 no 925 0.256949921093083 1235 260183
SGTC_1737 st035557 69.7 µM 0.65211884821976 0.269885096545778 no 926 0.257162252938605 1211 5716916
SGTC_2967 9089538 49.85 µM 0.650711201822777 0.270288581508491 no 927 0.257616465378794 1298 728216
SGTC_2168 5727979 200 µM 0.650204185571707 0.270433985480422 no 928 0.257780168886442 1199 695210
SGTC_191 3914-0123 66.505 µM 0.650204131700205 0.270434000931965 no 929 0.257780186283139 1191 3144412
SGTC_1448 4255-0083 152 µM 0.649286375724057 0.270697297730124 no 930 0.258076645165832 1317 5399660
SGTC_3276 9139060 49.47 µM 0.649244580610415 0.270709291458346 no 931 0.258090150274995 1314 4870619
SGTC_787 4152-0075 138 µM 0.648760679125567 0.270848173489219 no 932 0.258246538352849 1296 9566539
SGTC_913 3487-1245 167 µM 0.647177287380881 0.271302862873019 no 933 0.25875860459897 1225 4016153
SGTC_1184 1269-1718 139 µM 0.646358093858654 0.271538253071337 no 934 0.259023736535168 1296 5403821
SGTC_2471 5466956 24.79 µM 0.646041689985339 0.271629196991951 no 935 0.259126178228568 1250 724419
SGTC_406 estrone 100 µM 0.645707448338689 0.271725284490313 no 936 0.259234417982325 1311 5870 A steroid.
SGTC_2763 lisinopril 49.32 µM 0.645389466128938 0.271816713441246 no 937 0.259337414017707 1240 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2440 5628896 157.78 µM 0.644851880033553 0.271971319578713 no 938 0.25951158893098 1299 5522048
SGTC_2405 ticlatone 3.52 µM 0.644596664079493 0.272044733274559 no 939 0.259594298626892 1179 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2624 nerol 100 µM 0.644252048768686 0.272143878618334 no 940 0.259706002216543 1244 637566 A natural product oil.
SGTC_626 0214-0009 33 µM 0.638867237255658 0.273695410459067 no 941 0.261454651541994 1339 3437874
SGTC_1004 4084-0029 199 µM 0.63871190476518 0.273740231435636 no 942 0.261505183366575 1301 716894 YLR208W SEC13
SGTC_1091 telmisartan 47.6 µM 0.637714824007529 0.274028024134339 no 943 0.261829666987589 1346 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3190 9110366 49.47 µM 0.636573458991914 0.274357645795214 no 944 0.262201358897976 1223 17123768
SGTC_878 0828-0289 13.7 µM 0.633379226694067 0.275281166428427 no 945 0.263243013603424 1300 745350 YLR208W SEC13
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.632947748596272 0.275406033148295 no 946 0.263383882579693 1278 97141
SGTC_3354 9151612 71.43 µM 0.629238430919968 0.276480631643221 no 947 0.264596486227403 1292 27261949
SGTC_1779 st039427 55 µM 0.628223186049292 0.276775108550346 no 948 0.264928871694313 1380 1124498
SGTC_2132 5317594 122.667 µM 0.626094281690265 0.277393106472033 no 949 0.265626551352105 1324 794577
SGTC_1435 4092-0789 56.7 µM 0.625346279414308 0.277610403496269 no 950 0.265871905958844 1349 2248285
SGTC_1904 st060225 78 µM 0.624721096996395 0.27779208474261 no 951 0.266077062104841 1284 66595
SGTC_3099 9120367 49.47 µM 0.62314361406954 0.278250767341557 no 952 0.266595075645806 1308 24824940
SGTC_1480 1070-0044 41.2 µM 0.620907977675838 0.278901452164224 no 953 0.26733008593659 1335 3124987
SGTC_2240 6690706 185.951 µM 0.620891969372882 0.278906114069432 no 954 0.267335352671456 1234 805876
SGTC_914 3820-6779 408 µM 0.620761051500622 0.278944241126904 no 955 0.267378426642114 1284 2893481
SGTC_1142 3253-1408 9.78 µM 0.62047814768476 0.279026639529738 no 956 0.267471518254494 1301 256655
SGTC_1334 1486-0610 236 µM 0.620157141721136 0.279120149876115 no 957 0.267577167454849 1312 3742339
SGTC_1358 1509-0022 2.48 µM 0.618315757353571 0.279656846831797 no 958 0.268183608446771 1329 3258434
SGTC_2634 4'-methoxyflavone 100 µM 0.617353453921244 0.279937522612687 no 959 0.268500808120807 1320 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_871 0574-0004 149 µM 0.61721055483158 0.279979213745058 no 960 0.268547927371837 1321 9551173
SGTC_571 k831-0106 44.2 µM 0.615272099506665 0.280545059663872 no 961 0.269187519960644 1343 4783639
SGTC_1190 1486-1332 13 µM 0.61431011974096 0.280826072244632 no 962 0.269505208289886 1303 4150046
SGTC_2557 derrustone 83.84 µM 0.613734532171691 0.28099427736929 no 963 0.269695382610502 1298 629853 An antioxidant.
SGTC_1102 cgs 12066b 26.1 µM 0.612377415423932 0.281391062963119 no 964 0.270144040336996 1303 6438352 A 5-HT1B full agonist.
SGTC_1465 k213-0056 144 µM 0.611896828152474 0.281531638968563 no 965 0.270303010156713 1279 24048857 YMR208W ERG12
SGTC_2994 9053520 71.4286 µM 0.611703361143563 0.281588239333111 no 966 0.270367018842481 1341 4647384
SGTC_2764 methyldopa 94.69 µM 0.611260602617344 0.281717792628963 no 967 0.27051353429319 1374 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1600 coumarin 106 71.1 µM 0.611011101668754 0.281790810474995 no 968 0.270596115378874 1372 100336 A hepatotoxic, DNA x-linker.
SGTC_443 clozapine 122 µM 0.610998017673206 0.281794639831059 no 969 0.270600446333347 1260 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_108 0509-0257 621.132 µM 0.607471523468161 0.282827669183697 no 970 0.271769017611126 1298 536624
SGTC_1405 3909-7894 12 µM 0.607382597644728 0.282853742058022 no 971 0.271798517315064 1376 7104060
SGTC_2225 6654152 15.4 µM 0.606587880612384 0.283086802751696 no 972 0.272062222571631 1303 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2882 9058044 58.44 µM 0.606327956780767 0.283163048656232 no 973 0.272148498833433 1263 18076804
SGTC_2457 5731572 11.68 µM 0.605601768165175 0.28337612060156 no 974 0.272389613961148 1372 2865357
SGTC_2850 9015429 58.44 µM 0.605054799376879 0.283536658162284 no 975 0.272571293077557 1327 6457570
SGTC_1398 3558-0053 112 µM 0.603036557989054 0.284129396994859 no 976 0.273242184681014 1279 4532369
SGTC_1729 st035615 45.989 µM 0.602668561593428 0.284237537978124 no 977 0.273364599936962 1329 17385451
SGTC_3121 9125696 49.47 µM 0.601469394175794 0.284590066874883 no 978 0.273763695413513 1389 1235365
SGTC_1229 0139-0193 12.2 µM 0.599658360175531 0.285122866532675 no 979 0.274366972211466 1374 3090752
SGTC_611 3453-1652 23.7 µM 0.598670287829516 0.285413754175288 no 980 0.274696387232178 1363 1560575
SGTC_3051 9093778 49.47 µM 0.598197195541759 0.285553082148845 no 981 0.274854181245643 1348 17217378
SGTC_102 gallobenzophenone 83.616 µM 0.596688239635329 0.285997693150008 no 982 0.275357772906684 1422 70837
SGTC_2052 5265182 7.135 µM 0.594890206560983 0.286527909390853 no 983 0.275958432029723 1398 1239884
SGTC_1293 1000-1278 195 µM 0.59250328157847 0.287232501695815 no 984 0.276756811969734 1408 678847
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.592192783706238 0.287324217272357 no 985 0.276860750577712 1357 5106787 A p450 inhibitor.
SGTC_220 paclitaxel 373.376 µM 0.591972796339024 0.287389206032541 no 986 0.276934402524337 1361 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1747 st037496 66.6 µM 0.591119461244175 0.287641364420496 no 987 0.277220190544827 1362 723305
SGTC_1607 st000305 50.6 µM 0.590389864897286 0.287857041205446 no 988 0.277464651926465 1398 5457690
SGTC_2190 6049624 200 µM 0.589381249924667 0.288155324707196 no 989 0.277802775796663 1316 2265554
SGTC_730 1436-0052 41.2 µM 0.58892471746067 0.288290385601142 no 990 0.277955887945917 1349 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2846 9008642 19.48 µM 0.588911205368124 0.288294383483184 no 991 0.277960420267562 1349 2992898
SGTC_1659 st012954 42.1 µM 0.588332383786838 0.288465666504392 no 992 0.278154606552402 1349 24207262
SGTC_129 0088-0017 176.636 µM 0.587413778388096 0.288737595674753 no 993 0.278462921159439 1303 182446
SGTC_383 2324-0395 7.37 µM 0.586628033721845 0.28897029062523 no 994 0.278726775329771 1401 3146421
SGTC_725 1497-0963 19 µM 0.585766999124262 0.289225383640978 no 995 0.279016051653575 1415 3549977
SGTC_1433 4060-0023 7.6 µM 0.584816841701759 0.289507003282133 no 996 0.279335439378949 1385 3840627
SGTC_376 3970-0862 59.1 µM 0.584325564109705 0.28965266481932 no 997 0.279500647999655 1379 3135186
SGTC_3168 9103419 49.47 µM 0.584215299817902 0.289685362398938 no 998 0.279537734596541 1325 16649256
SGTC_378 3970-0959 8.33 µM 0.584036395607178 0.289738418024971 no 999 0.279597912816366 1377 6615653
SGTC_2475 5812728 15.03 µM 0.583960503084465 0.289760926001149 no 1000 0.279623442773106 1347 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1201 1889-3372 45.9 µM 0.580875794667819 0.290676473136953 no 1001 0.280662083527236 1321 5392199
SGTC_1788 fluconazole 20 µM 0.580626862822654 0.290750415529873 no 1002 0.280745981760614 1355 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_517 1365-0151 113 µM 0.577946244207253 0.291547219767435 no 1003 0.281650206274686 1397 768657
SGTC_210 3551-0445 56.827 µM 0.576518997752786 0.291971878641958 no 1004 0.282132216328086 1417 2865180 YOR207C RET1
SGTC_1696 st025591 34.7925 µM 0.576330160513259 0.292028086307756 no 1005 0.28219602022672 1382 2787147
SGTC_1429 4049-0205 9.46 µM 0.575337173205675 0.292323733211118 no 1006 0.282531642759953 1390 22774478
SGTC_2725 haloperidol 53.21 µM 0.574577470793276 0.292550017020091 no 1007 0.282788546197166 1332 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2259 7964009 200 µM 0.572435999043937 0.293188310248155 no 1008 0.283513316626878 1398 313134
SGTC_438 sphingosine 6.67 µM 0.57115441222105 0.293570612286992 no 1009 0.283947488656264 1238 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_175 3793-3120 23.7 µM 0.5684853429473 0.294367545449188 no 1010 0.284852727680415 1375 5322297
SGTC_2821 7996764 71.43 µM 0.567714093341369 0.294598011751075 no 1011 0.285114560149799 1432 2987135
SGTC_2015 5119600 184 µM 0.566458239101079 0.294973466578663 no 1012 0.285541156969843 1450 2828786
SGTC_1393 3470-5649 58.2 µM 0.565491370567153 0.29526267529005 no 1013 0.285869796084958 1349 4108395
SGTC_2756 carbadox 75.1 µM 0.565237793598482 0.295338546566916 no 1014 0.285956016786896 1378 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_5 0352-0601 109.883 µM 0.565138479116889 0.295368264314807 no 1015 0.285989788854176 1333 762456
SGTC_607 4491-0986 66.8 µM 0.561175823686366 0.296555125619437 no 1016 0.287338841220687 1464 698981 YDR232W HEM1
SGTC_2532 xanthone 78.9 µM 0.560617054291924 0.296722659160345 no 1017 0.287529311450038 1424 7020 An insecticide.
SGTC_889 0919-1524 82.7 µM 0.559879637078679 0.296943822253796 no 1018 0.28778076949981 1367 3905452
SGTC_2600 tangeritin 87.95 µM 0.559100892147095 0.297177462026329 no 1019 0.288046432963325 1341 68077 A bioactive flavone.
SGTC_1423 4048-0112 5.59 µM 0.558874224712386 0.297245482785276 no 1020 0.288123780738847 1436 X1423
SGTC_689 0833-0039 98 µM 0.558638771743164 0.297316147533684 no 1021 0.288204136857597 1411 5374726
SGTC_1677 st019204 53.9 µM 0.557320211197803 0.297712019073967 no 1022 0.288654334542046 1346 3945625
SGTC_992 3909-8734 162 µM 0.556310871098412 0.298015215739722 no 1023 0.288999178387755 1389 4288319
SGTC_1361 1608-0041 5.61 µM 0.555204831716564 0.298347621498455 no 1024 0.289377282212209 1365 X1361
SGTC_882 0843-0131 351 µM 0.555159603828887 0.298361217743288 no 1025 0.289392748484934 1400 5425421
SGTC_2292 7671323 168.05 µM 0.554153714416211 0.298663677457076 no 1026 0.289736825959821 1388 937504
SGTC_2618 avocadyne 43.43 µM 0.553857761772908 0.29875269364763 no 1027 0.289838096923985 1387 3015189
SGTC_2485 5633444 17.78 µM 0.553615301551848 0.298825629453385 no 1028 0.289921075881514 1347 5724239
SGTC_2774 tamoxifen 10.92 µM 0.552731581163168 0.299091534755831 no 1029 0.290223612319481 1428 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_820 1582-0060 59.9 µM 0.550242705624189 0.29984099666376 no 1030 0.291076457941923 1385 3848840
SGTC_3229 9132204 49.47 µM 0.549831866528369 0.299964792177706 no 1031 0.2912173497951 1443 17682924
SGTC_2191 5911152 200 µM 0.549806725393286 0.299972368545899 no 1032 0.291225972649703 1412 2875902
SGTC_2142 5622915 118.518 µM 0.549079581216261 0.30019153342318 no 1033 0.291475418619472 1388 5322196
SGTC_883 0850-0245 24.6 µM 0.548466824800269 0.300376277452227 no 1034 0.291685701344489 1508 6823229 YPR165W RHO1
SGTC_1675 st018485 24.5 µM 0.548255890561747 0.300439885310179 no 1035 0.291758105072891 1433 3323024
SGTC_2861 9024595 19.48 µM 0.545976669828824 0.301127578943037 no 1036 0.292540987151666 1382 16482810
SGTC_1697 st025554 27.742 µM 0.545276119228447 0.301339093689826 no 1037 0.292781812980204 1392 1269519
SGTC_2819 7996655 46.38 µM 0.543736924810933 0.30180405195066 no 1038 0.293311259508211 1427 6456960
SGTC_851 0394-0702 453 µM 0.543730790350156 0.30180590568724 no 1039 0.293313370505309 1441 762646
SGTC_2198 6589944 200 µM 0.542429086395762 0.302199375638666 no 1040 0.293761473420133 1415 5290268
SGTC_1455 4262-0120 131 µM 0.541714729461736 0.30241540424397 no 1041 0.294007520578964 1497 1529587
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.540415777998486 0.302808397364065 no 1042 0.294455164574614 1489 688761
SGTC_1793 st048256 72.231 µM 0.538973147224366 0.303245127974092 no 1043 0.294952691661487 1368 672022
SGTC_995 3931-2021 34.6 µM 0.53838219629071 0.303424109045119 no 1044 0.295156607556773 1464 730143
SGTC_2396 5342950 42.78 µM 0.538353934271239 0.303432669934002 no 1045 0.295166361388593 1441 1886677
SGTC_1071 trifluoperazine 6.31 µM 0.537945755408775 0.303556324010822 no 1046 0.295307249255081 1500 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1238 0333-0287 48.8 µM 0.537568927541629 0.303670500560562 no 1047 0.295437343413108 1410 7226
SGTC_3257 9139206 32.98 µM 0.53683641933653 0.303892500916255 no 1048 0.295690306262359 1410 4910041
SGTC_1750 st081859 2.357 µM 0.536441707151075 0.304012155852217 no 1049 0.295826656598555 1443 5291695
SGTC_212 3807-4682 38.772 µM 0.536320830070154 0.304048803307857 no 1050 0.295868418446861 1537 3125501 YBL034C STU1
SGTC_578 3460-0051 92 µM 0.534987756742883 0.304453094371583 no 1051 0.296329161712724 1463 2876744
SGTC_1668 st014914 51.6 µM 0.534632521803484 0.304560869473398 no 1052 0.296451995226531 1432 2839556
SGTC_2841 9004761 38.96 µM 0.534152477050164 0.304706537714574 no 1053 0.296618022674492 1328 2991039
SGTC_2734 clemastine 41.6 µM 0.533159965122165 0.305007810878806 no 1054 0.296961426121713 1439 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1337 1486-1011 40.3 µM 0.533143440424116 0.305012828006604 no 1055 0.296967145111681 1420 X1337
SGTC_23 0213-0011 39.996 µM 0.53156110714635 0.305493416038111 no 1056 0.297515003980485 1496 627608
SGTC_2731 amoxapine 43.43 µM 0.529123004808972 0.306234575498507 no 1057 0.298360061948093 1494 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2677 mitomycin C 100 µM 0.528916462199512 0.306297398955196 no 1058 0.29843170077904 1440 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1109 tnp00067 928.257 nM 0.526894970710361 0.306912570485294 no 1059 0.299133263285903 1428 676295
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.526526663434117 0.307024710804549 no 1060 0.299261165612587 1502 688751
SGTC_1870 st057514 26.5 µM 0.525223242296096 0.307421714770927 no 1061 0.299714004730327 1441 5393161
SGTC_648 0375-0473 33.3 µM 0.524106549652759 0.307762023399124 no 1062 0.300102216660068 1462 1713139
SGTC_1466 k213-0079 57.5 µM 0.523680390794018 0.307891937626453 no 1063 0.300250428331125 1433 3657981
SGTC_2260 7964312 200 µM 0.522990682612436 0.308102245704185 no 1064 0.300490368595351 1531 231951
SGTC_3092 9117248 49.47 µM 0.522832914510861 0.308150361730101 no 1065 0.300545266179053 1534 17141857
SGTC_3335 9143315 29.6265 µM 0.522327270338772 0.308304595017114 no 1066 0.30072124254247 1442 4899691
SGTC_2224 6650123 117.647 µM 0.520408696507075 0.308890112530914 no 1067 0.301389375011672 1439 2908370
SGTC_2614 arthonioic acid 13.39 µM 0.520247034528735 0.308939471357131 no 1068 0.3014457033934 1390 6710684
SGTC_1966 st070145 16.1 µM 0.520023729571131 0.30900765676515 no 1069 0.301523518020117 1388 3748532
SGTC_929 2805-0021 398 µM 0.518006194194603 0.309624002435804 no 1070 0.302226973796558 1495 3098024
SGTC_1866 st057638 64 µM 0.516916717478961 0.309957054310021 no 1071 0.302607148553615 1462 688802
SGTC_226 1,3-diallylurea 8.28947 mM 0.516046225098893 0.310223275050616 no 1072 0.30291106228847 1442 74537 YKL182W FAS1
SGTC_690 glyoxal 20.3 µM 0.514374529370487 0.310734804914546 no 1073 0.303495081752636 1366 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_565 1418-0001 44.5 µM 0.514274521298974 0.310765418458547 no 1074 0.303530036262769 1514 2862145
SGTC_705 1124-0212 310 µM 0.514195684601873 0.310789552141079 no 1075 0.303557592287185 1532 9554485
SGTC_1486 3970-0793 4.53 µM 0.513845448824374 0.310896777013985 no 1076 0.30368002473962 1513 2844330
SGTC_3280 9140961 49.47 µM 0.513365757805462 0.311043660736789 no 1077 0.303847746813589 1450 4901226
SGTC_32 0928-0142 34.1 µM 0.512505798129381 0.311307059920809 no 1078 0.304148531712522 1448 2244242
SGTC_233 rapamycin 362 pM 0.509111330524096 0.312347702383678 no 1079 0.305337095109839 1494 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2124 5246320 200 µM 0.508930715787015 0.312403115532012 no 1080 0.305400394551153 1494 579342
SGTC_194 1486-1323 56.904 µM 0.508529056046038 0.312526361163992 no 1081 0.305541183750011 1439 5178754
SGTC_702 1488-0190 94 µM 0.508520731666684 0.312528915645804 no 1082 0.305544101903834 1549 949357
SGTC_150 3970-0969 77.2 µM 0.508437489855774 0.312554460350882 no 1083 0.305573283426399 1510 6615640
SGTC_73 0327-0325 16.231 µM 0.507879340942439 0.312725764715225 no 1084 0.305768981839621 1487 53298
SGTC_1932 st074806 40.9 µM 0.50573169487542 0.313385286933715 no 1085 0.306522507502912 1548 17251235
SGTC_2462 5162487 171.77 µM 0.505669532791998 0.313404385236315 no 1086 0.30654432997206 1466 2259986
SGTC_1313 1220-0047 237 µM 0.504094514648799 0.313888451112849 no 1087 0.307097480701691 1524 3528706
SGTC_2448 5185112 27.17 µM 0.502694075682229 0.314319131063528 no 1088 0.307589687776444 1457 5718189
SGTC_2808 7946468 45.46 µM 0.502031443394455 0.314522999945 no 1089 0.307822701534581 1521 2970879
SGTC_542 3381-0244 89.3 µM 0.500982926808887 0.314845707547703 no 1090 0.308191569356153 1573 1112843
SGTC_2390 9097792 176.6 µM 0.499954532197503 0.315162359498008 no 1091 0.308553546544684 1424 4497149
SGTC_583 1488-1091 88.9 µM 0.495331272657798 0.31658757831908 no 1092 0.31018314974856 1544 4303273
SGTC_44 0929-0055 61.211 µM 0.492693443970239 0.317401969104521 no 1093 0.311114605357493 1437 1379590
SGTC_595 3909-8003 73.7 µM 0.491388072781239 0.317805310754475 no 1094 0.31157599923412 1520 699517
SGTC_512 prima-1 270 µM 0.489986735742198 0.318238545253605 no 1095 0.312071642491138 1559 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_3084 9116877 49.47 µM 0.488248134488419 0.318776393408782 no 1096 0.312687046901856 1463 27241325
SGTC_2656 pseudo-anisatin 100 µM 0.487178270324001 0.319107553098076 no 1097 0.313066001466921 1516 6708809 A neurotoxin.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.487000366498788 0.319162634450389 no 1098 0.313129035611701 1573 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_989 1501-0895 10.3 µM 0.486266427673501 0.319389913714375 no 1099 0.313389139494107 1546 2830112
SGTC_1226 3909-7979 35.4 µM 0.484599189175675 0.31990646055463 no 1100 0.313980344487099 1565 6615510
SGTC_1635 st007035 42.4 µM 0.484086767064737 0.320065290339943 no 1101 0.314162146111899 1526 3716403
SGTC_668 1682-0499 62.6 µM 0.483373969321069 0.320286283179958 no 1102 0.314415113764881 1511 682214
SGTC_3167 9103034 49.47 µM 0.482921613948322 0.320426562627285 no 1103 0.314575697201175 1512 5127859
SGTC_2715 st079500 56.4 µM 0.482393893490588 0.320590245890372 no 1104 0.314763079125793 1449 28246688
SGTC_1323 1348-1351 11.2 µM 0.481997222596163 0.320713304433987 no 1105 0.314903959643538 1493 6989654
SGTC_2908 7930301 100 µM 0.479721189682323 0.321419774858922 no 1106 0.315712829285425 1404 2223178
SGTC_1625 st003711 30.1 µM 0.477514676533051 0.322105283963668 no 1107 0.316497836207351 1592 24207034 YER133W GLC7
SGTC_2572 astragaloside iv 100 µM 0.476838558174545 0.322315458562005 no 1108 0.316738543306297 1533 45006101 An anti-inflammatory agent.
SGTC_1186 1319-0216 26 µM 0.476427571112516 0.322443243608721 no 1109 0.316884898083797 1633 4565136
SGTC_3324 9138759 60.749 µM 0.47632915352554 0.322473846946415 no 1110 0.316919949387628 1518 45595710
SGTC_650 1328-0195 38 µM 0.476159619030874 0.32252656718852 no 1111 0.316980332744749 1531 2780821
SGTC_952 1185-0122 232 µM 0.476139155557569 0.322532930968317 no 1112 0.316987621580688 1454 678600
SGTC_1386 3228-0095 33.8 µM 0.474180298682409 0.323142341427412 no 1113 0.317685670590548 1601 870181
SGTC_1414 3917-0015 5.4 µM 0.473515681097584 0.323349215379347 no 1114 0.317922658069566 1521 6618702
SGTC_1025 k007-0731 70 µM 0.472822205719631 0.323565130068143 no 1115 0.318170015100382 1492 6256118
SGTC_504 lovastatin 124 µM 0.472020704958473 0.323814752652361 no 1116 0.318456004959335 1476 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2652 actinonin 100 µM 0.471798360488029 0.323884014548433 no 1117 0.318535360638033 1524 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2644 guaiazulene 100 µM 0.46904397126762 0.324742531611591 no 1118 0.319519103144524 1573 3515 A coloring agent.
SGTC_772 k072-0172 35.3 µM 0.467620050696869 0.325186719879545 no 1119 0.320028161814984 1426 5861980
SGTC_2465 5809242 33.21 µM 0.466588483474257 0.325508669839156 no 1120 0.32039716406223 1592 2731748
SGTC_3310 9130229 44.1445 µM 0.462988071799124 0.326633369983301 no 1121 0.321686458556328 1586 7761258
SGTC_224 benfluorex 43.875 µM 0.458102667420214 0.328161998771402 no 1122 0.323439341320254 1637 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1108 betulinic acid 729.144 nM 0.458072063777554 0.328171583671963 no 1123 0.323450334317901 1530 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1400 3771-8998 51.5 µM 0.457560902261545 0.328331693502596 no 1124 0.32363396913773 1585 670767
SGTC_533 1222-0222 6.71 µM 0.45744706894705 0.328367353518619 no 1125 0.323674869615434 1642 3982874
SGTC_2108 5365811 200 µM 0.456425780221243 0.328687357651667 no 1126 0.324041915383834 1603 780283
SGTC_1074 carmofur 3.8 µM 0.456306045788279 0.328724882713705 no 1127 0.324084958519796 1550 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_921 1561-0023 372 µM 0.455979863176819 0.32882711789578 no 1128 0.324202229303132 1508 24050882
SGTC_2502 avocadyne acetate 18.59 µM 0.451696608862167 0.330170801299696 no 1129 0.325743780780529 1502 3952079
SGTC_1957 st077035 62.4 µM 0.451450177556226 0.330248175213589 no 1130 0.325832562918162 1582 705593
SGTC_2488 5268135 45.7 µM 0.449125347245511 0.330978476784667 no 1131 0.326670618213747 1619 1270356 YLR208W SEC13
SGTC_750 4073-0104 132 µM 0.446790641011777 0.331712528487856 no 1132 0.327513114669355 1465 22330957
SGTC_1626 st003712 1.76 µM 0.446160945057626 0.331910621148385 no 1133 0.327740495942781 1597 24207035
SGTC_3172 9105863 49.47 µM 0.443105612631526 0.332872448112199 no 1134 0.328844672852015 1596 2348785
SGTC_946 3434-1334 87.4 µM 0.442968277064457 0.332915707620297 no 1135 0.328894340209413 1643 4047976
SGTC_1147 3809-1045 12.3 µM 0.441492686003842 0.333380646177316 no 1136 0.329428177664811 1535 325925
SGTC_8 0354-0001 70 µM 0.441236068026162 0.333461529153369 no 1137 0.329521052127599 1589 4993152
SGTC_2078 5212016 200 µM 0.436690878120911 0.334895399790829 no 1138 0.33116777276315 1648 1899708
SGTC_1384 3089-0840 101 µM 0.43545304545545 0.335286317211899 no 1139 0.331616807080774 1675 1069836
SGTC_3327 9140648 26.9345 µM 0.433713930844007 0.335835844857819 no 1140 0.332248094577257 1667 8029710
SGTC_1706 st031321 9.9705 µM 0.433000371829448 0.336061417815767 no 1141 0.332507249848287 1651 6103185
SGTC_2122 5258151 111.688 µM 0.432856085992586 0.33610703717713 no 1142 0.33255966230836 1544 2173356
SGTC_2349 9023730 187.07 µM 0.431126560819071 0.336654054972474 no 1143 0.333188174419221 1674 4126287
SGTC_1887 st057648 70.8 µM 0.42929751160352 0.337232926684666 no 1144 0.333853363752365 1700 688672
SGTC_1508 1080-0625 72.9 µM 0.427946730134059 0.337660680106586 no 1145 0.334344952020971 1578 767111
SGTC_1373 2887-0003 58.5 µM 0.426411362954422 0.338147141246972 no 1146 0.334904061473169 1576 776948
SGTC_1943 st076331 65.2 µM 0.425990205345939 0.338280626847018 no 1147 0.33505749156525 1630 24208415
SGTC_3346 9158254 43.5805 µM 0.425478106055561 0.338442963733579 no 1148 0.335244089310488 1577 17639500
SGTC_31 0508-1974 57.237 µM 0.425352895124868 0.338482660513606 no 1149 0.335289719614292 1631 6810525
SGTC_3114 9122766 49.47 µM 0.424546881554974 0.338738241402885 no 1150 0.335583511257427 1530 17176985
SGTC_556 4058-0063 51.5 µM 0.424524340259484 0.338745390147609 no 1151 0.335591728997216 1610 6615692
SGTC_1064 honokiol 6.76 µM 0.424147652004327 0.338864861626429 no 1152 0.335729067524379 1591 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2929 9013348 24.6 µM 0.423891464701802 0.338946123955491 no 1153 0.335822484585805 1589 2995952
SGTC_634 1611-4317 11.2 µM 0.422330326897026 0.339441477014122 no 1154 0.336391962593216 1652 2843522
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.421813203114374 0.339605622962937 no 1155 0.336580683915363 1676 16725076
SGTC_1051 3253-3903 78 µM 0.42087590552659 0.339903218441752 no 1156 0.33692285013733 1551 5509239
SGTC_3290 9121031 71.43 µM 0.420052743161059 0.340164657880283 no 1157 0.337223461953668 1555 17014854
SGTC_1264 0783-0040 158 µM 0.419393901211553 0.340373963928206 no 1158 0.337464140278506 1527 2855798
SGTC_1776 st049249 45.9 µM 0.417595498905141 0.340945544591089 no 1159 0.338121444127375 1546 1822314
SGTC_1996 st072960 66.8 µM 0.416291728348746 0.341360146452616 no 1160 0.338598272296301 1678 1719405
SGTC_2565 isoliquiritigenin 100 µM 0.416034065512682 0.341442106476004 no 1161 0.338692538014091 1512 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2419 paclitaxel 166.5 µM 0.415131025125734 0.341729413784931 no 1162 0.339022994269073 1635 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1173 0443-0020 122 µM 0.414820913621345 0.341828098642475 no 1163 0.339136504260165 1581 5331295
SGTC_2904 7225135 42.03 µM 0.413792778296554 0.342155353051908 no 1164 0.339512936638562 1645 4446116
SGTC_1371 2421-0008 32.7 µM 0.413760289498726 0.342165696136775 no 1165 0.339524834412333 1609 2827552
SGTC_2330 7979373 200 µM 0.411291261972522 0.342952077982184 no 1166 0.340429488037849 1501 1863007
SGTC_1928 4'-methoxychalcone 40.3 µM 0.411283207728169 0.34295464436369 no 1167 0.340432440625848 1778 641818
SGTC_2678 equilin 100 µM 0.410994151624307 0.343046753173571 no 1168 0.340538411550125 1697 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2935 9038016 29.96 µM 0.410158130061221 0.343313207059035 no 1169 0.340844976445928 1636 6463195
SGTC_2679 rapamycin 1 nM 0.40859199528046 0.343812569673252 no 1170 0.341419553004999 1630 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_56 0957-0365 83.25 µM 0.408454625346611 0.343856383140578 no 1171 0.341469968237036 1592 6752360
SGTC_529 4076-0302 30.3 µM 0.407047009702523 0.344305455995025 no 1172 0.341986730822226 1594 5816522
SGTC_2397 5161689 200 µM 0.406224326563994 0.344568019042751 no 1173 0.342288890701433 1683 2259942
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.404958016990221 0.34497231382262 no 1174 0.342754185608598 1647 364106
SGTC_2506 ethyl hematommate 54.16 µM 0.404836887594332 0.345010996101664 no 1175 0.342798706112931 1543 3940691 An allergen.
SGTC_2922 7999257 32.47 µM 0.401974664568378 0.345925508277482 no 1176 0.343851335987911 1585 2988377
SGTC_3211 9128781 49.47 µM 0.401256648199701 0.346155063853354 no 1177 0.344115588794972 1569 17194361
SGTC_1929 genistein trimethyl ether 50.5 µM 0.39966885983174 0.346662893149363 no 1178 0.344700215500473 1797 136420
SGTC_1672 st016598 6.51 µM 0.394027402923059 0.348469449226775 no 1179 0.346780403926735 1582 4665860 YNL267W PIK1
SGTC_3218 9131285 49.47 µM 0.393701938693912 0.348573777610527 no 1180 0.346900554932628 1758 17156417
SGTC_840 0245-0196 390 µM 0.393497143607875 0.348639431066445 no 1181 0.346976166635027 1704 3827528
SGTC_2275 7947463 200 µM 0.393434180550459 0.348659616750652 no 1182 0.346999414237731 1666 1225414
SGTC_3 0833-0587 95.581 µM 0.390937184983851 0.349460487648819 no 1183 0.347921833597187 1639 5382644
SGTC_1832 st054113 55 µM 0.389841781571131 0.349812032395457 no 1184 0.348326773001907 1706 1251267
SGTC_2745 rifampicin 24.3 µM 0.387173942584926 0.350668752798642 no 1185 0.349313719756011 1760 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_441 propafenone 146 µM 0.385217941155347 0.351297364702457 no 1186 0.350037976001399 1616 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2696 st077691 74.316 µM 0.385064793938389 0.351346599744626 no 1187 0.350094705491923 1659 757133
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.381613710676609 0.352456742797954 no 1188 0.35137395645682 1646 689007
SGTC_155 k072-0202 43.6 µM 0.379601658781299 0.353104560023252 no 1189 0.352120564650812 1708 5857737
SGTC_447 ml7 120 µM 0.379384580784632 0.35317447777928 no 1190 0.352201149501228 1737 4216 Selective myosin light chain kinase inhibitor.
SGTC_467 ro 31-8220 72.8 µM 0.379275428879086 0.353209635938945 no 1191 0.352241671960931 1747 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.378466165794473 0.353470341094482 no 1192 0.352542161807329 1726 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_541 4513-1321 94 µM 0.377690064597304 0.353720427699444 no 1193 0.352830424685457 1615 747515
SGTC_2467 5474540 200 µM 0.377132535513486 0.353900121801634 no 1194 0.353037556728965 1626 5413519
SGTC_1230 0170-0365 3.77 µM 0.374684880055285 0.354689396688206 no 1195 0.353947419205749 1731 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2293 7624732 200 µM 0.373131468963988 0.355190636142683 no 1196 0.35452529919427 1588 894453
SGTC_2892 9047358 58.44 µM 0.370278946179139 0.356111712450157 no 1197 0.355587329633234 1652 6466771
SGTC_54 0159-0055 9 µM 0.36867372275711 0.356630407088473 no 1198 0.356185468665798 1779 3319099
SGTC_641 4092-0595 30 µM 0.368113641828326 0.356811448088102 no 1199 0.356394249652477 1727 786260
SGTC_1554 st069299 38.7 µM 0.366412777615046 0.357361434341843 no 1200 0.357028543285972 1737 24207999
SGTC_812 4251-0442 148 µM 0.366060912531561 0.357475249401573 no 1201 0.357159811749431 1775 5723007
SGTC_837 0091-0265 12.5 µM 0.363864454249557 0.358186006882749 no 1202 0.357979614597948 1654 759367
SGTC_2508 celastrol 40.54 µM 0.361037237723523 0.35910159660347 no 1203 0.359035805067126 1660 122724 Celastrol is a natural product and antioxidant.
SGTC_1309 pyrazolanthrone 13.4 µM 0.360227094861246 0.359364109643756 no 1204 0.359338657076601 1775 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2140 5586273 200 µM 0.360011663544445 0.359433927685093 no 1205 0.359419205668201 1674 854421
SGTC_1063 disulfiram 1.84 µM 0.357886411614506 0.360122940970376 no 1206 0.36021416004605 1691 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_460 trequinsin 123 µM 0.357319088824943 0.360306945757525 no 1207 0.360426470588793 1696 5537 A vasodilator.
SGTC_803 4488-1585 147 µM 0.357226794765845 0.360336883362689 no 1208 0.360461014084093 1769 747204
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.3569110952805 0.360439293897925 no 1209 0.360579181584485 1681 4620898
SGTC_363 0455-0021 3.06 µM 0.356607712670124 0.360537718366227 no 1210 0.360692751378903 1669 4597466
SGTC_3097 9117246 49.47 µM 0.355256338633938 0.360976248122618 no 1211 0.36119878077128 1668 16423892
SGTC_230 MPP+ 141.667 µM 0.354558056906716 0.361202916807084 no 1212 0.361460351450685 1650 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3253 9135987 49.47 µM 0.354070802400061 0.361361112987189 no 1213 0.36164291141454 1726 4182430
SGTC_678 1218-2179 85.9 µM 0.354024178631826 0.36137625149836 no 1214 0.361660381623987 1736 6820081 YOR116C RPO31
SGTC_2775 cyproheptadine 69.59 µM 0.352292425374434 0.361938696940808 no 1215 0.362309484086761 1775 2913 A selective serotonin reuptake inhibitor.
SGTC_117 lucigenin 22.078 µM 0.351807963768672 0.362096095684527 no 1216 0.362491142844851 1616 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1124 fisetin 1.16336 µM 0.351252451250202 0.362276607158554 no 1217 0.36269948169813 1667 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1647 st011722 22.4 µM 0.350988081843088 0.362362523653145 no 1218 0.362798644814851 1717 2854783
SGTC_2216 7189485 200 µM 0.348625664954537 0.363130584637876 no 1219 0.363685178672843 1778 731273
SGTC_798 1287-0182 476 µM 0.344931447323219 0.364332739227201 no 1220 0.365072954134555 1841 1649755
SGTC_639 0833-0042 114 µM 0.343025814184727 0.364953384273331 no 1221 0.365789520073801 1669 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_366 0181-0206 4.31 µM 0.341638869404774 0.36540532056049 no 1222 0.366311340901425 1881 274874
SGTC_112 phenothiazine 287.218 µM 0.340856905893657 0.365660206012479 no 1223 0.366605654088454 1867 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1765 st044815 90.4 µM 0.338868561209529 0.366308585242558 no 1224 0.367354374578837 1648 645695
SGTC_2746 daunorubicin 9.88 µM 0.33872990557289 0.366353813716203 no 1225 0.36740660486027 1829 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_61 0978-8327 98.565 µM 0.338002099907088 0.366591249134963 no 1226 0.367680802659604 1748 6150059 YHR072W ERG7
SGTC_633 0437-0093 97.7 µM 0.337238180857803 0.366840520918278 no 1227 0.367968678590776 1703 2831118
SGTC_2413 inermin 26.06 µM 0.336808165439003 0.366980862473896 no 1228 0.368130758619231 1851 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_319 1348-1596 45.5 µM 0.336036829279048 0.367232643369884 no 1229 0.368421546968405 1848 5380505
SGTC_2177 5811945 192 µM 0.335106715466001 0.367536328680682 no 1230 0.368772293624686 1807 5343475
SGTC_3325 9138760 55.175 µM 0.334165645846059 0.367843675426138 no 1231 0.369127283003159 1671 43844959
SGTC_1855 st056195 39.6 µM 0.334061766554841 0.367877606865356 no 1232 0.369166475097275 1835 4028379
SGTC_2459 5811157 9.22 µM 0.333849387146599 0.367946982312633 no 1233 0.369246606885984 1717 2870684 YBR192W RIM2
SGTC_1474 0330-0125 5.35 µM 0.33347689035915 0.36806867179587 no 1234 0.369387165464393 1714 X1474
SGTC_567 1080-0542 68.4 µM 0.332353739500466 0.368435669551808 no 1235 0.369811082768084 1825 5950415
SGTC_2893 9048488 25.97 µM 0.331806807359244 0.36861442711621 no 1236 0.370017571850256 1646 6467338
SGTC_1719 st032227 49.2 µM 0.330835522912107 0.368931948705906 no 1237 0.370384363488062 1663 3125804
SGTC_1463 k081-0032 34.1 µM 0.330485093214429 0.369046529289858 no 1238 0.370516727190043 1647 977755
SGTC_2033 5192550 145 µM 0.329610411552862 0.369332576171465 no 1239 0.3708471772964 1700 182073
SGTC_3169 9102970 49.47 µM 0.328682212665723 0.369636203908306 no 1240 0.371197950129662 1770 17027839
SGTC_2404 5161160 200 µM 0.327677195483216 0.369965051736004 no 1241 0.371577873808555 1768 2831543
SGTC_873 0591-4978 488 µM 0.327430690641826 0.370045724174728 no 1242 0.371671078429884 1900 3305145
SGTC_1425 4048-4433 7.33 µM 0.327375735649716 0.370063709806918 no 1243 0.371691858192453 1824 23734946
SGTC_737 1950-0117 57.9 µM 0.327090577698578 0.37015704066786 no 1244 0.371799689057547 1846 5393513
SGTC_3085 9117376 49.47 µM 0.326649703101288 0.370301351904255 no 1245 0.371966423084587 1777 16480349
SGTC_181 1447-1644 8.07 µM 0.325930402275672 0.370536839428337 no 1246 0.372238506450855 1862 534600
SGTC_427 1354-0053 47.3 µM 0.324949050981046 0.370858196298241 no 1247 0.372609816125523 1824 6813657
SGTC_409 arachidonic acid 100 µM 0.324066183711345 0.37114738022928 no 1248 0.372943964026662 1748 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_999 SEC7.066 22.7 µM 0.322029209754584 0.37181487019678 no 1249 0.373715283026236 1786 740511 YDR170C SEC7
SGTC_1721 st082152 9.2685 µM 0.320653364010975 0.372265935279756 no 1250 0.374236546276006 1716 5296051
SGTC_2726 cimetidine 79.27 µM 0.318136138572231 0.373091650157435 no 1251 0.375190835966074 1795 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2622 2-methoxyxanthone 59.94 µM 0.317844889070134 0.373187225225306 no 1252 0.375301299203819 1890 71034 A hepatoprotective.
SGTC_1603 st002045 67.8 µM 0.317247528858224 0.373383276555884 no 1253 0.37552789413005 1862 5887985
SGTC_2525 harmine 47.85 µM 0.317145417654456 0.373416792343304 no 1254 0.375566631978472 1817 5280953 A monoamine oxidase inhibitor
SGTC_1821 st053465 65.6 µM 0.316912258666419 0.373493325312256 no 1255 0.375655090025577 1744 675086
SGTC_2683 piperine 63.03 µM 0.316874819676286 0.373505614889939 no 1256 0.375669294590515 1765 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_156 3474-0145 5.642 µM 0.316077800552354 0.373767271798638 no 1257 0.375971728111792 1899 2265471
SGTC_3315 9136395 68.55 µM 0.315199822181578 0.374055574527973 no 1258 0.376304970283134 1902 16876844
SGTC_2588 indole-3-carbinol 100 µM 0.314412086495335 0.374314304144017 no 1259 0.376604038787608 1893 3712 Induces cell cycle arrest.
SGTC_1801 st050089 28.441 µM 0.312055005850848 0.375088818510712 no 1260 0.377499360176928 1754 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_507 nimesulide 162 µM 0.310801887279893 0.375500786781668 no 1261 0.377975617426783 1885 4495 A COX2 inhibitor.
SGTC_3192 9110362 49.47 µM 0.310114224951519 0.375726919188981 no 1262 0.378237047610074 1787 16649480
SGTC_3236 9132701 49.47 µM 0.308798084177332 0.376159840834821 no 1263 0.378737563288186 1734 24282524
SGTC_1752 st044819 83.042 µM 0.308315293565022 0.376318685526239 no 1264 0.378921214962235 1718 441209 YML126C ERG13
SGTC_559 1550-0661 158 µM 0.307913906463301 0.376450763304012 no 1265 0.379073921871721 1808 5830875
SGTC_1496 4469-0713 57.4 µM 0.306303003042992 0.37698098189329 no 1266 0.37968697646957 1884 746691
SGTC_1984 st072354 53.1 µM 0.306201573734493 0.377014374479762 no 1267 0.379725587126405 1793 5762938
SGTC_1341 1486-1360 280 µM 0.306107174881261 0.377045453324146 no 1268 0.379761522607585 1743 3976547
SGTC_2864 9034755 47.6 µM 0.302744924053343 0.378152922002228 no 1269 0.381042129459427 1922 4930451
SGTC_2266 7929956 200 µM 0.302657810503687 0.378181629089538 no 1270 0.381075326470493 1731 2967153
SGTC_1252 0493-0875 34.8 µM 0.302276151340276 0.378307407609679 no 1271 0.381220778493282 1746 3960963
SGTC_776 4476-4378 112 µM 0.299298029093532 0.379289311164339 no 1272 0.38235632913165 1773 2892008
SGTC_2990 9074105 71.4286 µM 0.296368095556792 0.380256087168336 no 1273 0.383474493756592 1799 6502001
SGTC_722 3534-0461 190 µM 0.295944527611105 0.38039591190685 no 1274 0.383636222598784 1747 658262
SGTC_138 0850-0259 40.9225 µM 0.295435100095267 0.380564100595739 no 1275 0.383830761626813 1819 6813004
SGTC_3134 9127454 49.47 µM 0.294314402799752 0.380934180862687 no 1276 0.384258833973383 1813 24262820
SGTC_1648 st011736 69.8 µM 0.293201739893905 0.381301715770875 no 1277 0.384683977130705 1871 2855514
SGTC_272 doxorubicin 8.13 µM 0.291266766875885 0.381941131083496 no 1278 0.385423651136095 1810 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1321 1326-2144 215 µM 0.290857966108729 0.382076261315457 no 1279 0.385579975128094 1908 3513030
SGTC_1043 0916-0009 19.3 µM 0.290703538430441 0.382127311554014 no 1280 0.385639032573903 1968 3101130
SGTC_3141 9094609 49.47 µM 0.289786737768458 0.38243042693517 no 1281 0.385989697234067 1721 25236309 YDL196W YDL196W
SGTC_719 2810-4230 27.3 µM 0.286685365742027 0.383456344964222 no 1282 0.387176621951781 1821 721079
SGTC_325 2810-4341 181 µM 0.284385530028517 0.38421764732076 no 1283 0.388057473395023 1917 774970
SGTC_2103 5378138 10 µM 0.282539237438037 0.384829139270924 no 1284 0.388765032224242 1857 244142
SGTC_3187 9109394 49.47 µM 0.281840291833299 0.385060704862795 no 1285 0.389032987165555 1753 17098090
SGTC_1717 st033143 58.0435 µM 0.280949363881737 0.385355934981345 no 1286 0.389374618939799 1917 674616
SGTC_2647 atorvastatin 60.16 µM 0.28053857014055 0.385492083629277 no 1287 0.389532169136245 1882 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1552 6-methylflavone 10.6 µM 0.279679933229206 0.385776705708663 no 1288 0.389861537571131 1924 689013
SGTC_18 0111-0177 500 nM 0.278225845665342 0.386258848750782 no 1289 0.390419497923808 1828 721752
SGTC_1540 guanosine 70.6 µM 0.2781911532951 0.386270354116637 no 1290 0.390432812791297 1918 6802 Guanosine is a purine nucleoside
SGTC_1529 apigenin 74 µM 0.278015953875761 0.386328458719945 no 1291 0.390500055966985 1929 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2516 gossypol 71.55 µM 0.277240333256103 0.38658572264737 no 1292 0.390797785735804 1918 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1771 st048882 4.1505 µM 0.275901439216671 0.387029934768237 no 1293 0.391311884234455 1746 4580403
SGTC_3198 9112019 49.47 µM 0.275841071540185 0.38704996677026 no 1294 0.391335068243972 1830 45595555
SGTC_2531 methyl deoxycholate 70.07 µM 0.275429342854684 0.387186600056818 no 1295 0.39149320159622 1786 16667744 Haematoxylin.
SGTC_1012 4112-3522 18 µM 0.272223665603401 0.388250889657665 no 1296 0.392725023101346 1925 3112398
SGTC_404 fumagillin 50 µM 0.271176634004677 0.388598688015091 no 1297 0.393127591625799 1847 12015870 A methionine aminopeptidase binder.
SGTC_1406 3909-7906 11.9 µM 0.270052464839885 0.38897220902562 no 1298 0.393559945679973 1874 X1406
SGTC_448 monastrol 171 µM 0.268130326840129 0.389611104026158 no 1299 0.394299501395429 1898 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_350 k064-0020 19.8 µM 0.267994769702452 0.389656172835141 no 1300 0.394351672350977 1964 2790705
SGTC_1865 st057639 52.2 µM 0.267564656795631 0.389799182698393 no 1301 0.394517219529442 1883 688818
SGTC_3265 9137266 49.47 µM 0.267534883747604 0.389809082603838 no 1302 0.394528679654028 2009 17224265
SGTC_3021 9087658 49.47 µM 0.267280552234121 0.389893653879903 no 1303 0.394626579659721 1949 25237042
SGTC_91 0417-1751 58.384 µM 0.266813156051004 0.39004908781483 no 1304 0.394806512145776 1930 6795624
SGTC_962 1254-0300 21.5 µM 0.266480685110184 0.390159662677782 no 1305 0.394934516417043 1826 7340576
SGTC_2707 st078556 66.6 µM 0.265337749169322 0.390539853819045 no 1306 0.395374643353749 1978 17250899
SGTC_1524 corynanthine 62.1 µM 0.264982128688837 0.390658170319698 no 1307 0.395511614550555 1866 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2884 9058502 51.95 µM 0.26461249566117 0.390781159587257 no 1308 0.395653996516823 1802 6471554
SGTC_576 1073-0113 22.7 µM 0.264502475939776 0.3908177689379 no 1309 0.395696378602689 1965 5439563
SGTC_2069 5228469 200 µM 0.261333804319787 0.391872566790883 no 1310 0.396917549995217 1831 2835210
SGTC_193 1273-0060 1.558 µM 0.260622108114402 0.392109588212836 no 1311 0.397191969463762 1935 2847393 YHR072W ERG7
SGTC_2289 7946404 165.07 µM 0.258252338946504 0.39289909802885 no 1312 0.398106083421527 1815 1246120 YPR165W RHO1
SGTC_1960 st011366 51.8 µM 0.258177623291744 0.392923997403188 no 1313 0.398134913338073 1854 3972846
SGTC_3258 9138477 49.47 µM 0.25633978121852 0.393536605375308 no 1314 0.39884424108876 1879 4970355
SGTC_77 0828-0286 12.516 µM 0.254403464690171 0.394182323034541 no 1315 0.399591937283254 1959 745345
SGTC_2987 9018338 71.43 µM 0.252777734481841 0.394724691977775 no 1316 0.400219987182342 1854 5055682
SGTC_773 4358-1457 44.6 µM 0.251683596191263 0.395089828544799 no 1317 0.400642818637728 2017 1186886
SGTC_1891 st059073 26.2 µM 0.251415975787335 0.39517915304397 no 1318 0.400746258705515 2007 688754
SGTC_13 0199-0087 65 µM 0.24678893240354 0.396724402893471 no 1319 0.402535788140617 1924 4589825
SGTC_2844 9010103 25.97 µM 0.246583628882265 0.396793003952982 no 1320 0.402615237821814 1857 2480525
SGTC_606 k015-0008 38.6 µM 0.244374048574138 0.397531525014069 no 1321 0.403470569409961 1981 1970475
SGTC_3161 9100388 49.47 µM 0.243557771820128 0.3978044470955 no 1322 0.403786668333827 1918 25236368
SGTC_3293 9120939 62.045 µM 0.243457459431963 0.39783798999018 no 1323 0.403825518124372 1927 934087
SGTC_2863 9028737 58.44 µM 0.243436975656721 0.397844839537313 no 1324 0.403833451362681 2015 6460917
SGTC_1809 st050081 57.6 µM 0.24210897271974 0.39828897608831 no 1325 0.404347862889402 1953 5036894
SGTC_1125 tnp00248 1.32998 µM 0.241459470032789 0.39850624342885 no 1326 0.404599512734694 2017 24207736
SGTC_1462 k081-0014 26.5 µM 0.240348723474442 0.398877875894095 no 1327 0.405029962948485 1848 3270634
SGTC_1340 1486-1359 257 µM 0.239747618702203 0.3990790311833 no 1328 0.405262958448369 1895 4309068
SGTC_2560 caryophyllene 100 µM 0.239246922374735 0.399246605989208 no 1329 0.405457060055521 1866 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1478 0453-0656 35.7 µM 0.239195169331398 0.39926392793885 no 1330 0.405477124139524 1957 5258496
SGTC_1370 2001-0092 44.6 µM 0.236748655710599 0.40008301151767 no 1331 0.406425892987027 1998 790957
SGTC_3226 9131256 49.47 µM 0.234099567937097 0.400970411970578 no 1332 0.407453840675157 1927 17178073
SGTC_1570 verbenone 133 µM 0.230936890930693 0.402030525457815 no 1333 0.408681915219738 2025 29025 A natural terpanoid with antifungal properties.
SGTC_3287 9117173 37.0625 µM 0.230915612278221 0.402037660406461 no 1334 0.40869018081986 2008 2789709
SGTC_2623 humulene 100 µM 0.230185565536006 0.402282472264182 no 1335 0.408973788881762 1854 6187145 An anti-inflammatory.
SGTC_2322 7413319 38.22 µM 0.229038142400563 0.402667323407814 no 1336 0.409419635313119 1897 1840400
SGTC_2856 9022925 19.48 µM 0.228232858234682 0.402937475883691 no 1337 0.409732609138295 1912 4944862
SGTC_2543 pimpinellin 60.67 µM 0.2274355329407 0.403205004018748 no 1338 0.410042546424639 1851 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1269 0831-0796 3.05 µM 0.227316123126546 0.403245073734323 no 1339 0.410088968401011 1987 927758
SGTC_3124 9127567 49.47 µM 0.227085553513073 0.403322447626225 no 1340 0.410178608628057 2010 17592030
SGTC_2020 4017018 200 µM 0.226703491144631 0.403450667354333 no 1341 0.410327156126562 1882 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3339 9145883 14.936 µM 0.226202388469285 0.403618852615343 no 1342 0.410522006512172 1985 2030670
SGTC_1141 3253-0389 52.6 µM 0.225185100400827 0.403960340145796 no 1343 0.41091763998217 2005 5402031
SGTC_2981 9013952 38.96 µM 0.225066747371562 0.404000074146537 no 1344 0.410963674548529 1782 2996344
SGTC_1559 coumarin 343 70.1 µM 0.225059495808038 0.40400250870562 no 1345 0.410966495154843 1979 108770 A hepatotoxic, DNA x-linker.
SGTC_3185 9108267 49.47 µM 0.224387160187507 0.404228247313018 no 1346 0.411228030336672 1843 4910486
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.22138811133066 0.405235573947474 no 1347 0.412395124282715 1922 4213774
SGTC_472 calcifediol 10 µM 0.219563698585841 0.405848669120035 no 1348 0.413105482911226 1930 5283731 A vitamin D metabolite.
SGTC_2801 7907800 81.82 µM 0.215581892918535 0.407187558010878 no 1349 0.414656835639729 1908 6620925
SGTC_3173 9105693 49.47 µM 0.214945280926995 0.407401720896754 no 1350 0.414904990402828 1979 17096658
SGTC_677 0929-0063 136 µM 0.214818297055975 0.407444442903345 no 1351 0.414954493461206 1970 1539583
SGTC_48 0382-0018 55 µM 0.213948047755893 0.407737256114472 no 1352 0.415293785458915 2041 762596
SGTC_1118 chelidonine 707.474 nM 0.213539137834971 0.407874860048161 no 1353 0.415453232715522 2066 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3351 9150312 21.596 µM 0.212287599830689 0.408296090724194 no 1354 0.415941334437385 2035 4904905
SGTC_870 0573-2213 57.6 µM 0.21097886375035 0.40873668594317 no 1355 0.416451882209609 2018 3916321
SGTC_3128 9127691 49.47 µM 0.210943720639419 0.40874851871192 no 1356 0.416465593748619 1949 41316314
SGTC_2945 9067681 61.76 µM 0.210088608571585 0.409036462581765 no 1357 0.416799258063974 2012 16456930
SGTC_2258 7960471 200 µM 0.209901786957519 0.40909937799718 no 1358 0.416872163754839 1892 2974708
SGTC_57 miconazole 162.5 nM 0.209876092869289 0.409108031109793 no 1359 0.416882190897867 1880 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2212 7123476 200 µM 0.207865726138195 0.409785208259933 no 1360 0.417666905600051 2019 1085715
SGTC_2885 9057732 51.95 µM 0.207547368986193 0.409892469250823 no 1361 0.417791201415108 1934 6471414
SGTC_1011 4112-3381 17.4 µM 0.202549837432435 0.411577117932148 no 1362 0.419743450542047 1973 2877139
SGTC_701 4424-0219 185 µM 0.201696037911682 0.411865094493726 no 1363 0.42007718011717 2079 2911779
SGTC_99 0109-0120 622.8 µM 0.200729609710028 0.412191116662444 no 1364 0.420455002855024 2038 759414
SGTC_884 0851-0618 334 µM 0.198175731900771 0.413052952174803 no 1365 0.421453787030212 2045 9642473
SGTC_3090 9117696 49.47 µM 0.198030618784671 0.413101934894311 no 1366 0.4215105538832 2053 7923821
SGTC_428 3448-4153 16.5 µM 0.197342849105052 0.413334108928489 no 1367 0.421779624924654 1831 3834874
SGTC_1973 st070275 50.2 µM 0.196945917544065 0.413468117005871 no 1368 0.42193493015086 2069 17118334
SGTC_296 1222-0039 74.9 µM 0.196810311586707 0.413513901248548 no 1369 0.421987990730767 1932 5984176
SGTC_25 0118-0223 35.662 µM 0.196687293668434 0.413555436445692 no 1370 0.422036127024608 2047 5333628
SGTC_2704 st078022 71.1 µM 0.196028295045011 0.413777954131452 no 1371 0.42229400969184 2071 54697681
SGTC_2686 alizarin 95.37 µM 0.195909107444182 0.413818202013671 no 1372 0.422340654346166 1912 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1920 st075728 45.7 µM 0.195396190974956 0.413991416611772 no 1373 0.422541399152378 2095 3400306
SGTC_1483 3453-0561 55.9 µM 0.194805584861452 0.414190888138183 no 1374 0.42277257498362 2029 4546991
SGTC_2870 9038528 12.99 µM 0.193859967947425 0.414510307218262 no 1375 0.423142764969989 1972 6463316
SGTC_2702 st077768 96.8 µM 0.190235728895761 0.41573505750482 no 1376 0.424562207345422 1927 6484119
SGTC_2977 9011197 71.43 µM 0.188486786252934 0.416326376795712 no 1377 0.425247536459368 2045 2704722
SGTC_1449 4112-4002 201 µM 0.187114117071557 0.416790610399157 no 1378 0.425785579908376 1905 2059539
SGTC_1289 0976-0073 69.1 µM 0.184567130975534 0.417652302326106 no 1379 0.426784284322458 2012 3391136
SGTC_3057 9095946 49.47 µM 0.180764834574339 0.418939423518095 no 1380 0.428276083143402 2068 24540043
SGTC_1479 0549-0158 134 µM 0.180301617561239 0.419096287417507 no 1381 0.428457892926072 1984 5440202
SGTC_3272 9137413 49.47 µM 0.179147132809804 0.419487298279333 no 1382 0.428911086979743 2106 17614870
SGTC_784 4579-0127 173 µM 0.178339260843998 0.419760962643336 no 1383 0.429228273649156 2079 1948547
SGTC_866 0495-0101 262 µM 0.175882027254798 0.420593581633559 no 1384 0.430193312704026 1891 635694
SGTC_2629 bisabolol 100 µM 0.174395538092309 0.421097442413413 no 1385 0.43077731033878 2036 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3126 9127922 49.47 µM 0.174200097067331 0.421163698789721 no 1386 0.430854104627522 2019 45595682
SGTC_2203 7227154 166.4 µM 0.173984758354199 0.421236703257706 no 1387 0.4309387203062 2089 896304
SGTC_905 2-aminofluorene 215 µM 0.172935174363226 0.421592573588139 no 1388 0.431351191515574 2095 1539 An established DNA mutagen. YPR165W RHO1
SGTC_906 1165-0455 526 µM 0.171988293927117 0.421913676373316 no 1389 0.431723365980275 1986 3252859
SGTC_1609 st001574 46.4 µM 0.17181848568059 0.421971266649111 no 1390 0.431790116088374 1959 3960012
SGTC_1298 1079-1278 263 µM 0.170825795771589 0.42230796966629 no 1391 0.432180372554063 1988 2840950
SGTC_1123 mangostin 811.285 nM 0.170433608843091 0.422441008260425 no 1392 0.43233457137233 1951 5281650 An antioxidant.
SGTC_1923 st058458 19.1 µM 0.169457910614171 0.422772025321243 no 1393 0.432718237990854 2126 3534982
SGTC_1088 bifonazole 369 nM 0.168622205125479 0.423055591575239 no 1394 0.433046906750073 2089 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1868 st057644 42.7 µM 0.168300185272579 0.423164867945719 no 1395 0.433173564057688 2066 688665
SGTC_1652 st011932 78 µM 0.167204571470115 0.423536705081553 no 1396 0.433604543772398 2089 1551076
SGTC_2031 5180455 200 µM 0.167079456268359 0.423579171899547 no 1397 0.433653765156569 2066 29949
SGTC_2376 9072922 81.32 µM 0.166904696274654 0.423638490724384 no 1398 0.433722518946194 2039 17087968
SGTC_2470 5664817 21.68 µM 0.166685546583083 0.423712879200144 no 1399 0.433808739291829 2145 2859561
SGTC_391 gliotoxin 8.33 µM 0.166537053633894 0.423763285398486 no 1400 0.433867162854575 2038 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_829 1635-0120 117 µM 0.165652878747968 0.424063445951459 no 1401 0.434215065450578 2115 285054
SGTC_7 0192-1582 4.227 µM 0.164945649677012 0.424303568488465 no 1402 0.434493380610609 2052 252616
SGTC_38 0929-0051 58.268 µM 0.164242410521074 0.424542364209725 no 1403 0.434770157817886 2124 1379719
SGTC_1662 st014054 52 µM 0.163623722448176 0.42475247221093 no 1404 0.435013684289791 2118 2838777
SGTC_2783 7738165 71.43 µM 0.163442614185758 0.424813981073228 no 1405 0.435084976345762 1935 17201110
SGTC_774 k060-0086 136 µM 0.163233917163258 0.424884862033503 no 1406 0.435167131149469 2141 5911235
SGTC_2053 5265679 138 µM 0.162631160394258 0.425089593382111 no 1407 0.435404425580035 2033 764595
SGTC_2860 9025725 38.96 µM 0.162432538792289 0.425157061289389 no 1408 0.435482624409665 1916 40546248
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.162242130523032 0.425221741344741 no 1409 0.435557591956618 1982 688664
SGTC_2057 5236571 38.335 µM 0.160202217491955 0.425914808245079 no 1410 0.436360891325342 2104 54684039 YBR257W POP4
SGTC_927 2425-1185 123 µM 0.159665358886678 0.426097245791073 no 1411 0.436572345181765 1960 730375
SGTC_2147 5545932 89.7195 µM 0.158340921659075 0.426547389179518 no 1412 0.437094082015361 2018 797404
SGTC_1316 1272-0050 65.9 µM 0.156340800493918 0.427227361991952 no 1413 0.437882198790941 2067 7340392
SGTC_1477 0139-0234 16 µM 0.155910297142198 0.427373746765422 no 1414 0.438051864311914 2133 620880
SGTC_298 1391-0729 10 µM 0.154452423512422 0.427869544124243 no 1415 0.43862651076541 2017 3237558
SGTC_664 1222-0054 14.9 µM 0.153176689986419 0.428303492294979 no 1416 0.439129469711335 2081 6813991
SGTC_2228 7354201 200 µM 0.151670062804203 0.428816091919954 no 1417 0.439723585189942 2093 753451
SGTC_998 3996-0085 177 µM 0.150669006345797 0.429156747725542 no 1418 0.440118411715105 2105 715391
SGTC_1553 gossypol 38.6 µM 0.146612841053209 0.430537583274189 no 1419 0.441718808761394 2136 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1418 3966-3099 2.4 µM 0.145864448532968 0.430792451013459 no 1420 0.44201419865985 2114 740335
SGTC_3238 9133470 49.47 µM 0.144773648857058 0.431163978330064 no 1421 0.442444794084421 2160 3534688
SGTC_2012 4023501 200 µM 0.142726744665846 0.431861319835034 no 1422 0.443252996883809 2028 3477460
SGTC_1671 st016596 74.5 µM 0.142311005691746 0.432002980250619 no 1423 0.443417176860027 2126 2829167
SGTC_1791 st048313 56.1 µM 0.141848219561335 0.432160681968806 no 1424 0.443599947708837 2168 1204976
SGTC_176 1486-1328 72.834 µM 0.140671947465389 0.432561563950274 no 1425 0.444064553683706 2032 22310231
SGTC_1847 st056231 15 µM 0.140361838300138 0.432667262963344 no 1426 0.444187053967386 2160 5393180
SGTC_1236 0330-0013 258 µM 0.138214700038321 0.433399235068162 no 1427 0.445035368824758 2035 4617066
SGTC_544 k015-0020 52.4 µM 0.138201295725754 0.433403805397751 no 1428 0.445040665541946 2056 3008304
SGTC_114 0364-0001 490.298 µM 0.137526568952773 0.43363387148927 no 1429 0.445307296639098 2006 4003655
SGTC_3277 9138724 49.47 µM 0.136641016170838 0.433935858446462 no 1430 0.445657277165477 2081 15943418
SGTC_594 1487-1584 10.8 µM 0.135281653590843 0.434399496720578 no 1431 0.446194595019649 2034 5013332
SGTC_3288 9119690 36.221 µM 0.135243798915739 0.434412409122402 no 1432 0.446209559328458 2040 17595618 YKL019W RAM2
SGTC_2868 9035608 32.47 µM 0.134990323036086 0.434498872699857 no 1433 0.446309762698706 2170 6462614
SGTC_143 4032-1194 15.74 µM 0.134656037901545 0.434612906046218 no 1434 0.446441916597346 2011 1806963
SGTC_2091 4-phenylthiadiazole 200 µM 0.133542912795758 0.434992661110942 no 1435 0.446882014333792 2081 270010
SGTC_484 loperamide 105 µM 0.133198151604498 0.435110292423302 no 1436 0.447018336314199 2177 3955 An opioid-receptor agonist.
SGTC_487 nimodipine 119 µM 0.131973280944672 0.435528260385228 no 1437 0.447502712792893 2188 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1402 3909-7673 35.9 µM 0.131726623330614 0.435612437167728 no 1438 0.447600263318629 2150 5328014
SGTC_1231 0242-0792 125 µM 0.130513003169101 0.436026651436463 no 1439 0.448080283546611 2058 3707635
SGTC_190 3970-0790 3.722 µM 0.130291720187813 0.436102183936348 no 1440 0.448167815281983 2170 2832352
SGTC_698 k064-0052 127 µM 0.130241977938749 0.436119163224183 no 1441 0.448187491907208 2180 5088751
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.1300873188677 0.436171956138367 no 1442 0.448248671470507 2050 75037 A free radical scavenger.
SGTC_1915 st067105 30.6 µM 0.128939575173774 0.436563774218537 no 1443 0.448702730783638 2165 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3010 9080089 71.4286 µM 0.127775071286323 0.436961377530765 no 1444 0.449163489280444 2182 17027233
SGTC_1322 1348-1070 12 µM 0.126343034870831 0.437450413296585 no 1445 0.449730196134766 2172 6758089
SGTC_2798 7813637 45.45 µM 0.123397387545849 0.438456641928256 no 1446 0.450896212850479 2127 956368
SGTC_2134 5324836 1.464 µM 0.12107194608463 0.439251290615255 no 1447 0.451817024734713 2118 699272
SGTC_170 4197-0004 226 µM 0.12082615617133 0.439335296185433 no 1448 0.451914366125079 2123 218692
SGTC_1329 1447-1697 50.6 µM 0.120210920650679 0.439545582084114 no 1449 0.452158033541272 2113 2840515
SGTC_1237 0330-0133 46.1 µM 0.120076203704682 0.439591630264129 no 1450 0.452211391337957 2119 X1237 YHR072W ERG7
SGTC_2673 kobusone 100 µM 0.119946906523839 0.43963582665953 no 1451 0.45226260332168 2185 6710676 An epoxy ketone and protein crosslinker.
SGTC_1500 4488-1866 171 µM 0.117793176560653 0.440372125409554 no 1452 0.453115768111564 2193 2900003
SGTC_2428 5615643 7.78 µM 0.1171899610968 0.440578384623868 no 1453 0.453354760993835 2152 2253075
SGTC_1872 amphotericin b 148 nM 0.115110982523629 0.441289379000126 no 1454 0.454178577488595 2172 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_589 1227-0070 34.1 µM 0.113957751990947 0.441683856557592 no 1455 0.454635642114093 2124 2841384
SGTC_3182 9108849 49.47 µM 0.113916249078799 0.441698054251196 no 1456 0.454652092258303 2112 17133045
SGTC_200 k038-0079 37.545 µM 0.113341939651072 0.441894526925086 no 1457 0.45487973420639 2154 3436683
SGTC_1808 st050063 61.5 µM 0.112050843075246 0.442336266375302 no 1458 0.455391546710443 2200 4011993
SGTC_1909 st060837 51.5 µM 0.111245010337389 0.442612012657802 no 1459 0.455711030012592 2100 678937
SGTC_1759 st043059 70 µM 0.110359037217233 0.44291521409962 no 1460 0.456062319102333 2098 669426
SGTC_2691 st077356 60.2 µM 0.110276751156586 0.442943376080317 no 1461 0.45609494734225 2176 2839272
SGTC_704 1310-0270 142 µM 0.109567986575263 0.44318595902966 no 1462 0.456376000383567 2108 5718033
SGTC_2204 7233102 200 µM 0.10931014579455 0.4432742133335 no 1463 0.456478249819141 2159 2172480
SGTC_1018 4259-0013 28.1 µM 0.108808818770381 0.44344581668998 no 1464 0.456677064492689 2110 6801262
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.108622254466196 0.443509680032105 no 1465 0.456751054341505 2147 5379071
SGTC_2014 4013930 200 µM 0.10799620712988 0.443723994738022 no 1466 0.456999350442918 2238 64556
SGTC_142 0335-0849 62.6745 µM 0.106875451344718 0.444107703994475 no 1467 0.457443894306696 2205 3889043 YPR107C YTH1
SGTC_2135 5326629 150.42 µM 0.105161474906479 0.444694613359193 no 1468 0.458123839869942 2120 5020077
SGTC_3323 9138564 53.9225 µM 0.103691241338052 0.445198155613043 no 1469 0.458707188792813 2214 43912313 YNL103W MET4
SGTC_1608 st001473 40.5 µM 0.102859734980849 0.445482978535315 no 1470 0.459037147484241 2048 7292267
SGTC_254 nsc-64875 3.808 µM 0.102820442686254 0.445496438355573 no 1471 0.459052740168682 2211 56993
SGTC_2146 5545642 200 µM 0.102740620353333 0.445523782186345 no 1472 0.459084416915542 2204 825326
SGTC_2723 salbutamol 83.58 µM 0.100636548357695 0.446244643306042 no 1473 0.45991949128982 2211 9884233 β2-adrenoceptor agonist
SGTC_2939 9044578 71.43 µM 0.10038670279602 0.446330252963781 no 1474 0.460018663034757 2197 2653634
SGTC_1487 3970-0795 2.82 µM 0.0998239446665143 0.446523091365662 no 1475 0.460242048950924 2163 3765103
SGTC_3066 9117245 49.47 µM 0.0990085184344969 0.446802533108829 no 1476 0.460565753303258 2187 17176980
SGTC_976 1348-1067 47.6 µM 0.0988881885027381 0.446843771704208 no 1477 0.460613523573245 2218 5310671 YGL099W LSG1
SGTC_1581 himbacine 57.9 µM 0.098189448099768 0.447083250257855 no 1478 0.460890930585789 2088 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_46 0329-0187a 2.197 µM 0.0973270608866051 0.44737884190282 no 1479 0.461233333265656 2158 46494817
SGTC_2575 plumbagin 510 nM 0.0971249513918331 0.447448121141196 no 1480 0.461313583093827 2146 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1053 3366-3204 134 µM 0.0970931442053437 0.447459024177595 no 1481 0.461326212635383 2127 3632071 YPR165W RHO1
SGTC_1987 st072290 61.9 µM 0.0964396406881683 0.447683044361786 no 1482 0.461585705056619 2117 54697379
SGTC_375 3970-0961 9.27 µM 0.0958830765286494 0.447873847018139 no 1483 0.461806717809627 2165 2898222
SGTC_1164 k060-0068 93.7 µM 0.0947921284393193 0.448247883403336 no 1484 0.462239969656888 2248 5963676
SGTC_835 0312-0010 67.2 µM 0.0946599984106651 0.448293187899478 no 1485 0.46229244594727 2207 1626196
SGTC_1914 st062367 72.6 µM 0.091429255483811 0.449401147386006 no 1486 0.463575758290349 2178 978205
SGTC_1806 st050005 60.3 µM 0.0908591789386302 0.44959669214306 no 1487 0.463802243232197 2119 5194765
SGTC_347 4534-1311 26.2 µM 0.0905141159707324 0.449715059837212 no 1488 0.463939338537605 2227 2862016
SGTC_1688 st021091 57.6 µM 0.0894833642066751 0.450068667441704 no 1489 0.464348886990873 2258 3656366
SGTC_1457 k015-0032 57.3 µM 0.0880356285491615 0.450565391578119 no 1490 0.46492417928852 2264 4302660
SGTC_918 glabranin 770.725 nM 0.0872670743349144 0.450829117248329 no 1491 0.465229612510491 2185 124049 Also referred to as licorice root.
SGTC_816 0325-0417 81.3 µM 0.0871110620379207 0.450882654769727 no 1492 0.465291616289194 2155 68101
SGTC_1864 st057645 30.4 µM 0.0869263531519011 0.450946041030647 no 1493 0.465365026007897 2270 688666
SGTC_2504 purpurogallin 52.29 µM 0.0867031346025973 0.451022644262023 no 1494 0.465453742375337 2090 5281571 An antioxidant.
SGTC_1082 camptothecin 424.86 nM 0.0860469786301397 0.451247831744225 no 1495 0.465714536068568 2256 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1907 st060210 83.7 µM 0.0850321080932478 0.45159615807241 no 1496 0.466117932286878 2222 688793
SGTC_287 k060-0039 29.6 µM 0.083711635711277 0.452049429561758 no 1497 0.466642852830139 2262 5861974
SGTC_2665 lovastatin 100 µM 0.0828455448449396 0.452346761921914 no 1498 0.466987177012264 2192 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2144 5628481 200 µM 0.082811457499225 0.452358464787898 no 1499 0.46700072932763 2209 2818399
SGTC_1416 3966-0321 25.3 µM 0.0815084083656699 0.45280585849633 no 1500 0.467518819110723 2215 582530 YLR208W SEC13
SGTC_826 1683-5028 118 µM 0.0779218227711999 0.454037597803987 no 1501 0.468945120063326 2194 722377
SGTC_2771 fluoxetine 41.05 µM 0.0771242080511013 0.454311582751933 no 1502 0.469262367556699 2229 3386 A selective serotonin reuptake inhibitor.
SGTC_932 2857-0803 154 µM 0.0763110612523091 0.454590925432179 no 1503 0.469585812949753 2257 674898
SGTC_2214 7179297 48.276 µM 0.0747816213164195 0.455116399113897 no 1504 0.470194232465748 2282 769744
SGTC_2082 5219693 150 µM 0.0739128721712837 0.45541491256807 no 1505 0.470539856677571 2271 2834649
SGTC_771 0250-0039 27.3 µM 0.0733757350328922 0.45559949244841 no 1506 0.47075356308684 2152 3005115
SGTC_98 0074-0023 107.663 µM 0.0732150753834643 0.455654702818156 no 1507 0.470817485081477 2108 3563821
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0725158726177184 0.455894992421171 no 1508 0.471095687100747 2264 65057 A dermal irritant. YDR527W RBA50
SGTC_3029 9088683 49.47 µM 0.0721840450300201 0.456009034690435 no 1509 0.471227721134897 2215 25236615
SGTC_2245 6637752 200 µM 0.0718141507424788 0.456136163967395 no 1510 0.471374905617192 2272 681890
SGTC_709 3807-1509 243 µM 0.0705447146712483 0.456572491583149 no 1511 0.471880056007034 2277 1886677 YPL242C IQG1
SGTC_3309 9129340 25.759 µM 0.0699408169581832 0.456780080315431 no 1512 0.472120382710706 2224 17158987
SGTC_1833 st055984 71 µM 0.0686420970071087 0.457226552805032 no 1513 0.472637254652579 2167 676288
SGTC_3244 9134489 49.47 µM 0.067625191829654 0.4575761810456 no 1514 0.473042000560089 2175 16584271
SGTC_3191 9110352 49.47 µM 0.0655365188281307 0.458294402864514 no 1515 0.473873415500205 2296 17122424
SGTC_1746 st038117 42 µM 0.0646649490049191 0.458594145743621 no 1516 0.474220385514709 2216 2898218
SGTC_3078 9116413 49.47 µM 0.0620050549576796 0.459509058736106 no 1517 0.475279403237712 2287 17177322
SGTC_284 0988-0104 32.6 µM 0.0605041511388812 0.460025413517122 no 1518 0.475877054889178 2274 4666532
SGTC_308 4092-1169 104 µM 0.0595863106958979 0.460341210734913 no 1519 0.476242560738643 2267 2268590 YDL196W YDL196W
SGTC_480 am 92016 50 µM 0.0595154537465403 0.460365591208351 no 1520 0.476270778492793 2177 2129 K+ channel blocker.
SGTC_2119 5528445 120.635 µM 0.059411102075475 0.460401496823679 no 1521 0.476312335251523 2262 791935
SGTC_1014 4130-3005 69.3 µM 0.0587584750037952 0.460626061887669 no 1522 0.476572241714654 2289 743608
SGTC_2264 7948757 110.76 µM 0.0579260944601757 0.460912497257434 no 1523 0.476903748821333 2309 2971411
SGTC_1900 st060200 72.8 µM 0.0577169244518905 0.4609844791749 no 1524 0.476987056202907 2288 688945
SGTC_2105 5350118 200 µM 0.0556026344839932 0.461712143599697 no 1525 0.477829182869547 2253 2133313
SGTC_573 3702-0553 84.7 µM 0.0555166145134377 0.461741751385655 no 1526 0.477863446947508 2293 1222756
SGTC_1741 st038134 10.228 µM 0.05436600740104 0.462137806823788 no 1527 0.478321780474451 2285 1272587
SGTC_368 fentichlor 4.58 µM 0.0539727927344496 0.462273165568123 no 1528 0.478478420444344 2243 7329 A pesticide.
SGTC_2002 4023503 131 µM 0.0536465003409966 0.46238549055759 no 1529 0.478608403956801 2327 4736863 YCR052W RSC6
SGTC_2094 5332512 191.667 µM 0.0529848814415277 0.462613259696044 no 1530 0.478871976826941 2304 755774
SGTC_2037 5169046 200 µM 0.0528114822404856 0.462672956192142 no 1531 0.47894105638208 2269 5718022
SGTC_1786 berberine 21.6 µM 0.0525820364837212 0.462751949242144 no 1532 0.479032464988665 2326 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2394 5221648 200 µM 0.0513398524364421 0.463179630892878 no 1533 0.479527356154073 2272 788586
SGTC_2358 9037157 4 µM 0.0513106033822849 0.463189701802496 no 1534 0.47953900947927 2261 2388925
SGTC_3007 9078383 71.4286 µM 0.0512991891210077 0.463193631918673 no 1535 0.479543557121618 2267 6496995
SGTC_733 4069-0007 56.1 µM 0.0512986312684947 0.463193823996476 no 1536 0.479543779379934 2314 5717425 YNL287W SEC21
SGTC_940 3232-1287 54.8 µM 0.0510575592599573 0.463276829860037 no 1537 0.479639827329857 2325 1585493 YIL048W NEO1
SGTC_2223 6903751 107.57 µM 0.0501650992528192 0.463584135390563 no 1538 0.479995411640936 2299 5598863
SGTC_2356 9061756 188.97 µM 0.0490174342861172 0.463979348924355 no 1539 0.48045270104448 2310 20104043
SGTC_1258 0671-0043 57.1 µM 0.0487274073502859 0.464079229158145 no 1540 0.48056826695342 2271 4298767
SGTC_2207 7258803 200 µM 0.0472663374782977 0.464582430518041 no 1541 0.481150478441642 2306 3666799
SGTC_2377 9073351 62.6 µM 0.04420563861763 0.465636736537503 no 1542 0.482370243741057 2301 7337946 YHR072W ERG7
SGTC_2643 anethole 100 µM 0.044159553985224 0.465652612978373 no 1543 0.482388610913352 2311 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1079 idarubicin 2.36 µM 0.0431708901911135 0.465993226895061 no 1544 0.482782654854516 2334 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1352 1496-0991 99 µM 0.0415438646152918 0.466553822984874 no 1545 0.483431162056759 2313 3000039
SGTC_1629 st005085 44.9 µM 0.0413472370807296 0.466621576053509 no 1546 0.483509537750461 2290 24207091
SGTC_3148 9097893 49.47 µM 0.0395898528652066 0.467227170659936 no 1547 0.4842100586693 2297 17174100
SGTC_2165 5727197 32.143 µM 0.0393477992617793 0.467310588308554 no 1548 0.484306548900645 2264 1361712
SGTC_2025 5147754 141 µM 0.0393210015214095 0.467319823559922 no 1549 0.484317231385157 2326 315777 YLR208W SEC13
SGTC_335 4077-0256 27.6 µM 0.0389904623404435 0.467433738058259 no 1550 0.484448996391282 2316 3121989
SGTC_1039 k821-0043 94 µM 0.0388620048058999 0.467478009401873 no 1551 0.484500204721559 2316 15992768
SGTC_2073 5212005 126 µM 0.0382375636322879 0.467693221259541 no 1552 0.484749135668178 2336 691789
SGTC_337 1315-0038 354 µM 0.0381463188351042 0.467724669309174 no 1553 0.484785510537317 2314 1626437
SGTC_3096 9117468 49.47 µM 0.0381139183604329 0.467735836369544 no 1554 0.484798427063447 2337 41316311
SGTC_387 norethindrone acetate 66.7 µM 0.0356085301647173 0.468599412936559 no 1555 0.48579725327444 2299 541197
SGTC_2877 9040724 71.43 µM 0.035065932343961 0.468786459353443 no 1556 0.486013583373716 2353 6463895
SGTC_2529 gangaleoidin 93.61 µM 0.0347517145163997 0.46889478088971 no 1557 0.486138861792844 2338 4565183
SGTC_1756 st041558 35.5 µM 0.0341366439218134 0.469106823230447 no 1558 0.486384093939546 2348 3955792
SGTC_1388 3346-4487 254 µM 0.0319151541540302 0.469872742646617 no 1559 0.487269856764427 2317 3345614
SGTC_895 0964-0006 13.7 µM 0.0317279574303812 0.46993728897455 no 1560 0.487344499650447 2338 6738897
SGTC_15 0266-0086 27.098 µM 0.0310838503364156 0.470159386213818 no 1561 0.487601334505597 2350 1712902 YIL048W NEO1
SGTC_1365 1672-3266 55.4 µM 0.0301639213827778 0.4704766068137 no 1562 0.487968160997857 2339 6415873
SGTC_1325 1431-0015 227 µM 0.0299538924801852 0.470549034056761 no 1563 0.48805191256215 2345 1103340
SGTC_1200 1643-0193 18.4 µM 0.02931991516812 0.470767663337242 no 1564 0.488304721861106 2349 5403974
SGTC_2193 5925765 200 µM 0.0287805344333568 0.470953677598873 no 1565 0.488519812860359 2335 877370
SGTC_2875 9039966 71.43 µM 0.028252340113776 0.471135840184354 no 1566 0.488730446244661 2319 6463691
SGTC_703 3875-0075 71.8 µM 0.0280751486799151 0.471196950961336 no 1567 0.488801107369625 2329 2850814
SGTC_1300 1094-0077 113 µM 0.0272862749380768 0.471469030379755 no 1568 0.489115701903302 2352 5532636
SGTC_1154 4088-0362 150 µM 0.0258693042864664 0.471957771283107 no 1569 0.489680791740041 2354 6618304
SGTC_1367 1812-0510 76.9 µM 0.0250813395842327 0.472229574045208 no 1570 0.489995042177538 2343 1142582 YDR527W RBA50
SGTC_1512 0259-0544 12.2 µM 0.0248903389698678 0.472295460286889 no 1571 0.490071216616811 2310 18476
SGTC_2700 st077718 96.8 µM 0.0237074177618826 0.472703529365473 no 1572 0.490542994575775 2342 904970
SGTC_974 1326-0144 138 µM 0.0233175328381272 0.47283803319503 no 1573 0.490698493166779 2332 5411856
SGTC_1573 oleylamine 1.06 µM 0.0200590119897764 0.473962288465854 no 1574 0.491998148627234 2350 5356789 An amine of the fatty acid oleic acid.
SGTC_1686 st019653 115.5 µM 0.0188798686399855 0.474369168226774 no 1575 0.492468469588709 2379 97252
SGTC_2992 9074591 71.4286 µM 0.0165187000329192 0.475184002137634 no 1576 0.493410291827108 2378 17741321
SGTC_2958 9077254 16.72 µM 0.0155854012822125 0.475506110225969 no 1577 0.493782576179467 2345 16457351
SGTC_2701 st077767 14.721 µM 0.0155536051183056 0.475517084274583 no 1578 0.493795259476235 2365 5721188
SGTC_353 1988-1175 58.3 µM 0.013904470793871 0.476086287646488 no 1579 0.494453097448722 2338 2788357
SGTC_1181 1222-0449 220 µM 0.0137558027079618 0.47613760327174 no 1580 0.494512401761964 2376 658318
SGTC_2425 5628681 7.85 µM 0.0132867631844558 0.476299503798754 no 1581 0.494699504353049 2367 5714958
SGTC_227 fluconazole 33.516 µM 0.0126496687496961 0.47651941887297 no 1582 0.494953646884324 2373 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1060 3448-7350 82 µM 0.0107114465631784 0.477188506674126 no 1583 0.495726832795546 2376 570178
SGTC_1419 3993-2473 62.6 µM 0.0105873907221818 0.477231333824515 no 1584 0.495776321109301 2388 704026
SGTC_2059 5238311 157 µM 0.0105197513948883 0.477254684707193 no 1585 0.495803303794093 2380 703021
SGTC_2965 9082772 38.63 µM 0.0102015963194815 0.477364521290504 no 1586 0.495930222492726 2389 16459634
SGTC_936 3005-4620 401 µM 0.00955142560818014 0.477588984872773 no 1587 0.496189590423983 2391 777207
SGTC_2088 5278280 127.392 µM 0.00913298025429604 0.477733451840151 no 1588 0.49635651868183 2380 791502
SGTC_1262 0737-0114 49.6 µM 0.00844764062133969 0.477970069545903 no 1589 0.496629919069533 2390 765919
SGTC_2414 st077232 92.9 µM 0.00647023523336151 0.478652824101844 no 1590 0.497418767611376 2383 729801
SGTC_2173 5763948 167 µM 0.00550454002520907 0.478986280294289 no 1591 0.497804017339486 2396 2867177
SGTC_429 1112-0049 25.5 µM 0.00520272129729618 0.479090501840617 no 1592 0.49792442386509 2394 2836170
SGTC_1097 itavastatin 7.23 µM 0.00335103079776878 0.479729943311302 no 1593 0.498663134633877 2403 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1387 3342-1166 1.8 µM 0.00280670015114177 0.479917926183316 no 1594 0.498880290111399 2390 3418228
SGTC_55 0767-0285 6.563 µM 0.00278707778677416 0.479924702788621 no 1595 0.498888118271568 2397 3116166
SGTC_311 1315-0136 58 µM 0.00249689392826767 0.480024918782434 no 1596 0.49900388447738 2400 6759207
SGTC_2962 9082311 13.18 µM 0.00156766993419024 0.480345837949307 no 1597 0.499374590437704 2398 16459453
SGTC_2172 5754775 163.918 µM 0 0.480887281200966 no 1598 0.5 2406 2263357
SGTC_2006 4011487 200 µM -0.000158924349002874 0.480942172620758 no 1599 0.499936598358064 2406 45595294
SGTC_522 1273-0010 11.6 µM -0.000332162112570175 0.481002008210936 no 1600 0.499867486491785 2413 5705015
SGTC_2367 9070478 135.38 µM -0.00125887795758556 0.481322099176614 no 1601 0.499497780489504 2410 572802
SGTC_2511 berberine 10.47 µM -0.00245137250115621 0.481734008743839 no 1602 0.499022044843735 2408 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1701 st028638 40.4 µM -0.00309790221484805 0.48195734018897 no 1603 0.498764117802741 2413 3490878
SGTC_2181 6316240 54.2555 µM -0.003186076070762 0.481987798617916 no 1604 0.498728941697234 2415 12779990
SGTC_651 3253-0966 34.4 µM -0.00387542205860453 0.482225927186654 no 1605 0.498453934156457 2411 781462
SGTC_2334 9017922 200 µM -0.00808390296069707 0.483679844666537 no 1606 0.496775024443437 2427 3163164
SGTC_2066 5222451 176 µM -0.00860715577955655 0.483860630070683 no 1607 0.496566284042324 2421 2281147
SGTC_189 3970-0742 2.116 µM -0.00896094508132313 0.483982867208388 no 1608 0.496425147977333 2428 2891807
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.00992209650856241 0.484314960564233 no 1609 0.496041721140057 2430 5024745
SGTC_1713 st033146 12.748 µM -0.010056849134874 0.484361520649921 no 1610 0.495987965302269 2423 674619
SGTC_2553 4-methylesculetin 85.09 µM -0.0101262238666552 0.484385491274869 no 1611 0.495960290197816 2415 5319502
SGTC_1655 st012546 55.1 µM -0.0108952881450759 0.484651225091818 no 1612 0.495653494895593 2449 720985 YLR208W SEC13
SGTC_2079 5212404 121 µM -0.0123040859843311 0.485138022841211 no 1613 0.495091503729445 2430 758462
SGTC_1152 3909-8331 15.9 µM -0.0128772689883832 0.485336087586311 no 1614 0.494862854921863 2432 16001939
SGTC_520 3584-0023 682 µM -0.0132868116274423 0.485477608234359 no 1615 0.494699485028799 2459 1340790
SGTC_1646 st011709 75.6 µM -0.0133093534826409 0.48548539780123 no 1616 0.494690492924794 2427 5757843
SGTC_2045 5106652 78.05 µM -0.0140395788634229 0.485737737572509 no 1617 0.494399202388281 2427 673349
SGTC_2391 6285546 200 µM -0.0145401245804994 0.485910711572929 no 1618 0.494199533927726 2431 846083
SGTC_545 4218-0007 221 µM -0.0155230994138916 0.486250406689211 no 1619 0.493807428022441 2445 2840508
SGTC_3341 9147222 25.867 µM -0.0158974399511244 0.486379773423456 no 1620 0.493658106184133 2459 1939759
SGTC_483 fpl-64176 144 µM -0.0165443195907291 0.486603329143233 no 1621 0.493400072498812 2434 3423
SGTC_315 k915-0449 187 µM -0.0166477313698058 0.486639067705633 no 1622 0.493358822848912 2448 20970215 YNL149C PGA2
SGTC_408 cantharidin 100 µM -0.0192268518407885 0.487530432032233 no 1623 0.492330068444214 2465 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1835 st008666 49.2 µM -0.0194318534090876 0.487601284918278 no 1624 0.492248299927976 2443 690455
SGTC_2949 9072542 2.23 µM -0.0194865868616785 0.487620202025594 no 1625 0.492226468573323 2456 16457352
SGTC_1129 3453-1384 223 µM -0.0212234793439579 0.488220525216383 no 1626 0.491533692345639 2522 1084452
SGTC_1440 4100-1550 40 µM -0.0234739422426714 0.488998393553429 no 1627 0.490636111917171 2443 742806
SGTC_2113 5491891 107.031 µM -0.0237066175800611 0.489078819790806 no 1628 0.490543313712442 2457 789979
SGTC_518 1021-0119 62.6 µM -0.0239361539162569 0.489158161440494 no 1629 0.490451767941141 2472 1097762
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0250109067883819 0.489529666735157 no 1630 0.490023131985857 2452 15053
SGTC_2276 7947513 42.08 µM -0.0258588865640717 0.489822790756711 no 1631 0.489684946420098 2504 2105100
SGTC_2386 9075165 157.42 µM -0.0265033956652578 0.490045584070834 no 1632 0.489427912601268 2460 16452277
SGTC_3110 9122132 49.47 µM -0.0270621680639656 0.49023874251651 no 1633 0.48920507460632 2554 918317
SGTC_1761 st044296 37 µM -0.0276488594315144 0.490441554554269 no 1634 0.488971106176103 2451 1826700
SGTC_2306 7482397 179.52 µM -0.0277943069271288 0.490491834360781 no 1635 0.488913103312057 2462 891448
SGTC_250 brefeldin a 552.239 µM -0.0286602602442061 0.490791189230878 no 1636 0.488567775534268 2442 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1963 st076565 50.3 µM -0.0288930435121559 0.490871661902613 no 1637 0.488474946890181 2455 4914280
SGTC_2792 7535235 81.82 µM -0.0290346972509584 0.490920631475476 no 1638 0.488418458923654 2497 1281891
SGTC_2278 7948257 134.34 µM -0.0292320263065077 0.490988848184287 no 1639 0.488339769421424 2458 1247028
SGTC_21 0849-0113 22.993 µM -0.0304479088836625 0.491409184865493 no 1640 0.487854918392721 2449 1560156
SGTC_403 arphamenine a 50 µM -0.0305712264388252 0.491451816901043 no 1641 0.487805744697676 2478 5487158 An arginine aminopeptidase inhibitor.
SGTC_22 0964-0034 14.468 µM -0.0305984808169606 0.491461239008406 no 1642 0.48779487685817 2466 138402
SGTC_3015 9080845 49.47 µM -0.0319153403605139 0.491916495919986 no 1643 0.487269782516612 2493 5296973
SGTC_3311 9131146 2.8755 µM -0.032112520613005 0.491984664834312 no 1644 0.487191159277639 2506 4900406 YPR165W RHO1
SGTC_777 1315-0167 517 µM -0.0322522589252417 0.492032975133569 no 1645 0.487135440618295 2510 4221767
SGTC_2161 5662504 8.5105 µM -0.0324522073708139 0.492102101470237 no 1646 0.487055714463875 2491 2859334
SGTC_103 0844-0104 51.839 µM -0.0333739386158879 0.492420766168773 no 1647 0.486688196026887 2524 5375804
SGTC_3107 9121808 49.47 µM -0.0349406223964772 0.492962417486887 no 1648 0.486063544193779 2474 662681
SGTC_1193 1488-0126 41.5 µM -0.0351209265744702 0.493024755101498 no 1649 0.485991657355629 2495 1384710
SGTC_1136 pergolide 1.05886 µM -0.0356088134030579 0.49319343590883 no 1650 0.485797140350306 2477 47811 A dopamine receptor agonist.
SGTC_727 3032-0951 202 µM -0.0356258957848805 0.493199341952267 no 1651 0.485790329787244 2501 3652836
SGTC_85 0868-0259 160.055 µM -0.0360868840152286 0.493358724062147 no 1652 0.485606540278312 2545 83173
SGTC_1523 st012844 44.7 µM -0.0363904298307505 0.493463672598648 no 1653 0.485485522507724 2565 4274103
SGTC_3234 9132280 49.47 µM -0.0365149199800241 0.493506714202725 no 1654 0.485435891109713 2518 17612295
SGTC_2310 7668677 200 µM -0.0366206397664319 0.493543266143647 no 1655 0.485393743206623 2507 2197143
SGTC_1557 sumaresinolic acid 42.3 µM -0.0370645828819763 0.493696757228622 no 1656 0.485216755689445 2461 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2933 9026794 32.47 µM -0.0371579641803374 0.493729043459393 no 1657 0.485179527586312 2505 17586027
SGTC_1919 st067113 52.3 µM -0.0375013736053703 0.493847776321125 no 1658 0.485042622470015 2515 1268243
SGTC_2982 9019404 25.97 µM -0.0379726787322101 0.494010729654266 no 1659 0.484854732762611 2485 22333232
SGTC_856 0433-0016 11.3 µM -0.03802048906023 0.494027260089424 no 1660 0.484835672964993 2518 3911780
SGTC_1871 st057448 67.3 µM -0.0393804416795889 0.494497468299065 no 1661 0.484293536545497 2514 691747
SGTC_198 3454-2873 16.191 µM -0.0397920770256958 0.494639794146928 no 1662 0.484129446423879 2489 710957
SGTC_2308 7584454 197.62 µM -0.0398824013555851 0.494671024518157 no 1663 0.484093440811643 2489 893577
SGTC_3069 9117009 49.47 µM -0.0399684492987731 0.494700776324307 no 1664 0.484059139998299 2474 41904981
SGTC_1687 st020778 55.3625 µM -0.0414598038872438 0.495216429361236 no 1665 0.483464668567016 2491 4259299
SGTC_115 0527-0192 112.043 µM -0.0441164984413071 0.49613503136707 no 1666 0.482405770866868 2525 4233931
SGTC_3349 9149703 23.001 µM -0.0453274057116024 0.496553732375734 no 1667 0.481923171641963 2468 4910494
SGTC_2612 dictamnine 15.46 µM -0.0476583292055413 0.497359716862338 no 1668 0.48099427240876 2539 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_199 4063-0024 41.6 µM -0.0498423932116647 0.498114930259006 no 1669 0.480123991874433 2578 306215
SGTC_1270 0831-1170 17.3 µM -0.0504672063453989 0.498330981721177 no 1670 0.479875040817758 2493 6764716
SGTC_553 k007-0256 45.7 µM -0.052245577142673 0.498945919421837 no 1671 0.479166508595523 2534 6287000
SGTC_2312 7706453 155.7 µM -0.0532901997117141 0.499307137703637 no 1672 0.478750344302421 2526 976098
SGTC_2138 5575593 77.673 µM -0.0539166632531413 0.49952376176976 no 1673 0.478500780309951 2508 762213
SGTC_2791 5663188 71.43 µM -0.0543554702379144 0.499675496390796 no 1674 0.478325977987738 2553 54690634
SGTC_3137 9097352 49.47 µM -0.0552853567026831 0.499997041013914 no 1675 0.477955563991155 2559 44120435
SGTC_1443 4112-3303 14 µM -0.055293913900057 0.5 no 1676 0.477952155377275 2510 704433
SGTC_399 oxolinic acid 75 µM -0.0560297274883822 0.499745563655136 no 1677 0.477659062620459 2517 4628 A DNA gyrase inhibitor.
SGTC_2495 cafestol 54.53 µM -0.0563209791446493 0.499644852019429 no 1678 0.477543053209157 2682 16667697 An anti-infammatory.
SGTC_96 0929-0093 37.281 µM -0.0574329821852307 0.499260333799748 no 1679 0.477100145184539 2502 6991579
SGTC_257 daunorubicin 18.5 µM -0.0588642742048687 0.498765410082379 no 1680 0.476530106870708 2631 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2071 5230951 39.92 µM -0.059972418566963 0.498382228238291 no 1681 0.476088800966468 2512 1799272
SGTC_45 0kpi-0036 14.9 µM -0.0617289965274801 0.497774829726002 no 1682 0.475389324053064 2563 2795021
SGTC_1149 3909-7961 23.3 µM -0.0646399769708901 0.496768268054269 no 1683 0.474230327115531 2532 735261
SGTC_2804 7954240 19.48 µM -0.0646587239572737 0.496761785762734 no 1684 0.474222863763025 2578 828705
SGTC_880 0833-0487 87.2 µM -0.0649654389586998 0.496655730649817 no 1685 0.474100758908095 2515 76075
SGTC_234 nsc-17383 10.7 µM -0.0660908938639971 0.496266575871139 no 1686 0.473652730322676 2539 408974
SGTC_1296 1068-0102 11.9 µM -0.066815812016799 0.496015918762575 no 1687 0.473364167685186 2591 767053
SGTC_1260 0700-1617 7.75 µM -0.0677263517299426 0.495701080974823 no 1688 0.473001735910707 2575 2853078
SGTC_1076 itraconazole 331 nM -0.0680717879309809 0.495581640010829 no 1689 0.472864244109292 2512 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0691882213439532 0.495195615245074 no 1690 0.472419899323007 2603 521171
SGTC_2522 biochanin a 4.94 µM -0.069498216135651 0.495088430354512 no 1691 0.472296526269797 2565 5280373 A possible chelator.
SGTC_2829 7992743 58.44 µM -0.0700264351063133 0.494905792324567 no 1692 0.472086309553893 2552 16462845
SGTC_1502 4534-4282 27.7 µM -0.073490878905462 0.493707947650442 no 1693 0.470707751014105 2562 3278949
SGTC_2180 6301957 200 µM -0.0753900726347261 0.493051317549983 no 1694 0.469952178810933 2544 845462
SGTC_52 0329-0193 875 nM -0.0764235247303671 0.492694018062411 no 1695 0.469541077152523 2730 3739292
SGTC_755 1995-0008 37.3 µM -0.0764665947201491 0.492679127429446 no 1696 0.469523944845083 2535 689533
SGTC_1572 epiandrosterone 68.9 µM -0.0778752411257527 0.492192120366738 no 1697 0.468963647152951 2565 441302 A steroid.
SGTC_2743 auranofin 4.32 µM -0.0790588317936471 0.491782930111476 no 1698 0.468492914222353 2577 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_390 dec-rvkr-cmk 16.7 µM -0.0808127380652915 0.491176586715691 no 1699 0.467795438846825 2601 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1157 4092-0394 27.6 µM -0.080884386312955 0.491151817605187 no 1700 0.467766948596963 2702 3659885
SGTC_3116 9124943 49.47 µM -0.0809152043141349 0.491141163698773 no 1701 0.467754694160257 2558 41905195 YPL160W CDC60
SGTC_331 k048-0133 24.5 µM -0.0809267245203335 0.491137181118982 no 1702 0.467750113285752 2537 6813582
SGTC_1198 1612-1005 86.7 µM -0.081842140852205 0.490820721014028 no 1703 0.467386122450854 2687 6998509
SGTC_1285 0929-0069 65.5 µM -0.082405818786048 0.490625859995789 no 1704 0.46716200453381 2580 1206237
SGTC_344 k064-0035 6.43 µM -0.0826062874471385 0.490556559385577 no 1705 0.467082300852726 2557 5088750
SGTC_619 1652-1634 108 µM -0.082754865916921 0.4905051970344 no 1706 0.467023228875005 2597 5400454
SGTC_2809 7964133 12.99 µM -0.0834949144909155 0.490249370709946 no 1707 0.466729010461376 2590 1253665
SGTC_671 0560-0003 407 µM -0.0843408055104169 0.489956960781958 no 1708 0.466392734927123 2651 3238678
SGTC_2106 5357045 167.29 µM -0.0852477219695109 0.489643461412613 no 1709 0.466032225993284 2651 668842
SGTC_3044 9093193 49.47 µM -0.0855915373413125 0.489524614308466 no 1710 0.465895562997745 2644 25236277
SGTC_2341 7987486 176.74 µM -0.0861835661775474 0.489319969120723 no 1711 0.465660247193444 2578 1258686
SGTC_3209 9113616 49.47 µM -0.0867578644253447 0.489121455509017 no 1712 0.465431990300596 2575 16649353
SGTC_371 0195-0006 7.36 µM -0.086952315691817 0.48905424152388 no 1713 0.465354707522665 2536 3928593
SGTC_981 1488-1094 54.9 µM -0.087556666117082 0.488845343872052 no 1714 0.46511452263727 2563 3449522
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0879957816674224 0.488693562644668 no 1715 0.464940014439853 2546 1241132 A phosphatase inhibitor.
SGTC_2956 9076196 2.52 µM -0.0887168001106939 0.488444344642446 no 1716 0.464653490312911 2579 16423868
SGTC_1778 st046819 58.9 µM -0.0913941980707489 0.48751894980354 no 1717 0.463589685862809 2574 671715
SGTC_1792 st045773 43.6 µM -0.0927397432812569 0.487053911165164 no 1718 0.463055161238437 2570 2919270
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.0929874265766228 0.486968310365231 no 1719 0.462956775039767 2597 688801
SGTC_2936 9038235 15.59 µM -0.0937283006527454 0.486712263537713 no 1720 0.462662494281462 2560 4749415
SGTC_3055 9094636 49.47 µM -0.0945545005888919 0.486426734471812 no 1721 0.462334345556747 2672 25236176
SGTC_540 1187-0821 17.3 µM -0.0952575297376363 0.486183777864112 no 1722 0.462055137779814 2590 847520
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.0957639150752858 0.486008781657995 no 1723 0.461854038598952 2587 279621
SGTC_2610 ononetin 44.17 µM -0.0968647056472868 0.48562838074592 no 1724 0.461416918887842 2650 259632
SGTC_950 1165-0508 94.1 µM -0.0974046381464654 0.48544180068085 no 1725 0.4612025307688 2637 6148369
SGTC_3254 9136651 49.47 µM -0.0974348584505875 0.485431357790915 no 1726 0.461190531686361 2576 16454030
SGTC_468 gf-109203x 121 µM -0.0976557553745454 0.485355025234137 no 1727 0.461102824827318 2582 2396 A protein kinase C inhibitor.
SGTC_2379 9035213 200 µM -0.0980396476180194 0.485222369724172 no 1728 0.460950405375513 2568 646551
SGTC_2101 5377231 179.231 µM -0.0985712921874588 0.485038660507045 no 1729 0.460739332250827 2658 2844213
SGTC_3117 9124945 49.47 µM -0.0989390932805108 0.484911569085425 no 1730 0.460593314608655 2559 17592065
SGTC_2255 7941087 197.44 µM -0.0991271545847336 0.484846586241601 no 1731 0.460518656011653 2575 935561
SGTC_1783 st039459 87.517 µM -0.0998439495463475 0.484598908079051 no 1732 0.460234107831159 2788 729761
SGTC_1990 st072050 59.8 µM -0.099847781669415 0.484597583960069 no 1733 0.460232586636716 2564 17233948
SGTC_3215 9129942 49.47 µM -0.100902267773804 0.484233232367612 no 1734 0.459814021437457 2620 17682944
SGTC_933 2914-0560 114 µM -0.102364443075161 0.483728035704214 no 1735 0.459233702846518 2604 463887
SGTC_2314 7727897 200 µM -0.103241490018828 0.48342501941124 no 1736 0.458885655776738 2609 900724
SGTC_957 1187-1561 14.1 µM -0.103291689446749 0.483407675992976 no 1737 0.458865735600427 2571 1538454
SGTC_2842 9000675 19.48 µM -0.104454694966808 0.483005877657792 no 1738 0.458404259858086 2669 2989072
SGTC_248 streptozotocin 5.23457 mM -0.105335888215324 0.482701452068972 no 1739 0.458054643344997 2681 5300 DNA alkylating agent.
SGTC_2381 9035592 200 µM -0.106452027002638 0.48231587440919 no 1740 0.457611857981018 2624 4749657
SGTC_160 3453-0671 289.699 µM -0.106638418975979 0.482251485648862 no 1741 0.457537919207714 2618 5322268
SGTC_2721 ifenprodil 61.44 µM -0.10767723221328 0.481892638076002 no 1742 0.45712586527512 2677 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_630 4356-0227 183 µM -0.108283573920965 0.481683190200179 no 1743 0.456885376054183 2605 779312
SGTC_3224 9130643 49.47 µM -0.10948637646529 0.481267722603596 no 1744 0.456408363406896 2716 17644395
SGTC_656 4090-1979 187 µM -0.111305042052323 0.480639564661566 no 1745 0.455687228636316 2626 22330961
SGTC_361 000s-0510 1.45 µM -0.111662414372689 0.480516135662529 no 1746 0.455545540941502 2670 660
SGTC_2973 9094665 17.96 µM -0.112203427869997 0.4803292843621 no 1747 0.455331055644047 2849 25237061 YIL048W NEO1
SGTC_1233 0325-0408 14.2 µM -0.113970700745955 0.479718946865064 no 1748 0.454630509745896 2684 12874
SGTC_515 4092-1064 102 µM -0.113984037812046 0.479714341014231 no 1749 0.454625223474647 2676 717353
SGTC_411 enrofloxacin 100 µM -0.114109761291692 0.479670923532977 no 1750 0.454575392189241 2717 71188 A bacterial gyrase inhibitor.
SGTC_1481 3346-2004 36 µM -0.114739828491681 0.479453339094278 no 1751 0.454325671908611 2620 2770522
SGTC_783 0848-0141 92.7 µM -0.11610657880191 0.478981373112776 no 1752 0.453784037475194 2602 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1591 genipin 88.4 µM -0.117026219778314 0.478663819394884 no 1753 0.453419637928956 2773 442424 A DNA cross-linking agent.
SGTC_964 1287-0107 19.4 µM -0.117787121345731 0.478401088916543 no 1754 0.453118167092599 2720 51516812 YPR165W RHO1
SGTC_1568 digitonin 820 nM -0.118273143645363 0.478233275963462 no 1755 0.452925618142455 2646 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2824 7998404 51.95 µM -0.118620712687207 0.478113270280666 no 1756 0.452787927430621 2615 837851
SGTC_402 epigallocatechin gallate 10 µM -0.118926781955545 0.478007594929505 no 1757 0.45266668170157 2619 65064 An antioxidant.
SGTC_2706 st078239 82.5 µM -0.119264907456112 0.477890853445095 no 1758 0.452532742405621 2627 15434492
SGTC_1422 4031-0024 15.5 µM -0.119292201468993 0.477881429974698 no 1759 0.452521930854079 2600 782427
SGTC_348 k064-0012 10.7 µM -0.120244865849605 0.477552522967964 no 1760 0.45214458888772 2584 5066323
SGTC_3329 9141233 27.5565 µM -0.121350639990209 0.477170774063984 no 1761 0.45170665571877 2744 4909101 YNL103W MET4
SGTC_62 0180-0423 3.232 µM -0.121720519874042 0.477043084254567 no 1762 0.451560180782956 2652 30102 YGL099W LSG1
SGTC_1764 st044502 93.5 µM -0.122995207493537 0.476603055161555 no 1763 0.451055446509323 2717 8407
SGTC_2443 5493264 126.67 µM -0.123934751078772 0.476278737843375 no 1764 0.450683468834058 2737 5340055
SGTC_1519 esterone 74 µM -0.124582657889676 0.476055098605977 no 1765 0.450426979209832 2619 698 A steroid.
SGTC_1093 fluphenazine 7.97 µM -0.124864096475908 0.47595795625466 no 1766 0.450315571363288 2640 6602611 An atypical antipsychotic.
SGTC_260 nsc-65238 3.989 µM -0.125150195371871 0.475859206798794 no 1767 0.450202322739614 2711 3246252
SGTC_2201 6605497 169.863 µM -0.125875018066307 0.475609034760333 no 1768 0.449915429028225 2669 670741
SGTC_69 0096-0274 206.684 µM -0.126059388279996 0.475545401041989 no 1769 0.44984245720639 2924 6741392
SGTC_3062 9077494 49.47 µM -0.127179599712336 0.475158783624356 no 1770 0.449399125664112 2717 16459633
SGTC_1055 3448-0672 86 µM -0.128297166491747 0.474773102259106 no 1771 0.44895690369397 2771 748378
SGTC_1086 cerivastatin 2.18 µM -0.129369416175856 0.47440308240747 no 1772 0.448532673321067 2631 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3180 9109287 49.47 µM -0.13081899067155 0.473902887679341 no 1773 0.447959249858494 2750 18891271
SGTC_853 0419-0306 21 µM -0.13106533666404 0.473817886825592 no 1774 0.44786181095405 2638 762713
SGTC_3212 9128307 49.47 µM -0.131598441316508 0.4736339449495 no 1775 0.447650959226461 2660 27243542
SGTC_2241 6772625 37.8075 µM -0.133031470298598 0.473139522090189 no 1776 0.447084245994895 2605 2285411
SGTC_3138 9097216 49.47 µM -0.133470872679386 0.472987927979847 no 1777 0.446910499189206 2593 25237486
SGTC_1725 st036284 20.55 µM -0.134749619192924 0.472546781930281 no 1778 0.446404920237491 2884 707914
SGTC_2331 7980721 200 µM -0.13542266073941 0.472314607402861 no 1779 0.44613885424325 2751 2981221
SGTC_1969 st069479 40.1 µM -0.136252011112802 0.472028525036938 no 1780 0.445811029790715 2775 3895485
SGTC_2034 5197015 53.07 µM -0.136312531006716 0.472007649411946 no 1781 0.445787109019405 2783 780676
SGTC_1539 benzyladenosine 56 µM -0.136924646760059 0.471796511620417 no 1782 0.445545178509411 2644 92208 A nucleotide analog.
SGTC_2972 9093619 59.92 µM -0.137206116525029 0.471699426586982 no 1783 0.445433938174609 2663 25236256
SGTC_1447 4239-0816 81.9 µM -0.137947467562157 0.471443726579961 no 1784 0.44514096765013 2643 1341554
SGTC_430 0958-0115 16.4 µM -0.138734853257549 0.471172161612739 no 1785 0.444829837748661 2688 6833180
SGTC_1561 5-methoxyflavone 52.9 µM -0.138777813926291 0.471157345100406 no 1786 0.444812863119562 2626 94525
SGTC_3217 9129673 49.47 µM -0.13892227500641 0.471107522859446 no 1787 0.444755784367577 2791 17248312
SGTC_2608 thymoquinone 42.66 µM -0.13953806346066 0.470895152672002 no 1788 0.44451248992263 2619 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1254 0550-0035 264 µM -0.139887545571523 0.4707746286249 no 1789 0.444374420861444 2786 15121435
SGTC_2823 7987624 58.44 µM -0.140249968265906 0.470649644654777 no 1790 0.444231246524415 2793 2239440
SGTC_961 1252-1571 372 µM -0.140683533345625 0.470500130540662 no 1791 0.444059977096865 2757 6813498
SGTC_1856 st057054 55.7 µM -0.140938221088822 0.470412303882047 no 1792 0.443959373715317 2889 1266018
SGTC_758 0868-0029 16 µM -0.141687678168029 0.470153869063852 no 1793 0.443663354070723 2788 762687
SGTC_1772 st048439 82.2 µM -0.142413961019089 0.469903437393269 no 1794 0.443376517742385 2723 2927068 YDL195W SEC31
SGTC_2934 9036370 36.88 µM -0.142729555209222 0.469794620160937 no 1795 0.443251887001878 2758 6462800
SGTC_2484 5809818 12.04 µM -0.143563473005613 0.469507095242314 no 1796 0.44292259305475 2714 2870548
SGTC_3308 9128332 17.569 µM -0.144849032317794 0.469063880912986 no 1797 0.442415034114427 2811 17332805 YDL196W YDL196W
SGTC_1081 sertraline 6 µM -0.146244285845365 0.468582891384979 no 1798 0.441864273151821 2761 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_266 formosanin C 406 nM -0.146524058446097 0.468486450115127 no 1799 0.441753849490588 2686 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1728 st035614 33.7865 µM -0.146612991598312 0.468455794083003 no 1800 0.441718749344623 2794 15945546
SGTC_2534 helenine 20.12 µM -0.146946405884433 0.468340864941305 no 1801 0.441587161435136 2673 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2174 5790901 200 µM -0.147311469030278 0.468215029346626 no 1802 0.441443090131642 2755 786020
SGTC_3194 9111903 49.47 µM -0.147592259473066 0.46811824432681 no 1803 0.441332282120617 2827 17087251
SGTC_2709 st078560 56 µM -0.150752455198741 0.467029094936676 no 1804 0.440085496385032 2756 17250903
SGTC_3347 9188721 44.724 µM -0.151821127584043 0.466660836519066 no 1805 0.439664008948956 2759 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2234 tolnaftate 200 µM -0.152001665973665 0.46659862682749 no 1806 0.43959281083211 2700 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1975 st070967 30.8 µM -0.152071102127764 0.466574700821896 no 1807 0.439565428126832 2725 261391
SGTC_1212 0520-0165 585 µM -0.153671579414709 0.466023249028637 no 1808 0.438934347451677 3073 5403258
SGTC_509 pifithrin 175 µM -0.156560672208892 0.465027964710897 no 1809 0.437795549631898 2686 4817 A p53 inhibitor.
SGTC_109 0132-0036 33.701 µM -0.156630399841711 0.465003946416532 no 1810 0.437768071318812 2651 67274 A color developer.
SGTC_1531 st059297 52.4 µM -0.156937227185414 0.464898258564427 no 1811 0.4376471601575 2801 7566702
SGTC_2298 7976326 193.81 µM -0.158889388572299 0.464225887415696 no 1812 0.436878010589898 2735 2235818
SGTC_917 harmaline 728.087 nM -0.159192640641017 0.464121449256611 no 1813 0.436758550921612 2779 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_416 estradiol valerate 100 µM -0.161802336928641 0.463222788732276 no 1814 0.435730756345839 2751 13791 A steroid.
SGTC_33 0986-0033 35.816 µM -0.163626881349696 0.462594609926637 no 1815 0.435012440828078 2691 2848082
SGTC_531 3788-1495 174 µM -0.163700704207348 0.462569195148627 no 1816 0.434983381574973 2656 2896655
SGTC_568 1193-0097 7.48 µM -0.165284241596605 0.462024072353102 no 1817 0.434360130806258 2736 3646150
SGTC_3014 9081533 49.47 µM -0.166494762311733 0.461607406252797 no 1818 0.433883802358256 2809 21367265
SGTC_1624 st003710 6.25 µM -0.16684771681878 0.46148592580512 no 1819 0.433744936143745 2876 24207033
SGTC_2955 9076254 12.21 µM -0.166873808680107 0.461476945608989 no 1820 0.433734670901505 2752 16459619
SGTC_1770 st043884 66.3 µM -0.167102692062348 0.461398170252242 no 1821 0.433644623919826 2700 670149
SGTC_1331 1472-0049 76.2 µM -0.16740594158395 0.461293802451475 no 1822 0.433525325220074 2703 24051409
SGTC_667 1498-1044 59 µM -0.167719426667101 0.461185914733354 no 1823 0.433402006205331 2732 6739982
SGTC_476 mead acid 10 µM -0.168271624743157 0.460995879500251 no 1824 0.433184797857435 2696 5312531 An omega 9 fatty acid.
SGTC_336 4111-0029 111 µM -0.169192215828636 0.460679084127552 no 1825 0.432822726196731 2765 3131175
SGTC_2417 cerulenin 830 nM -0.169384552487583 0.460612900053624 no 1826 0.432747086634566 2681 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2352 9027995 87.8 µM -0.169987489037455 0.460405433438963 no 1827 0.432509987878557 2768 2997347
SGTC_2003 4023581 200 µM -0.171320446151719 0.459946809746343 no 1828 0.431985902213492 2827 16641307
SGTC_1473 k844-0725 134 µM -0.171475272227764 0.459893542977838 no 1829 0.431925036181653 2731 54682906
SGTC_121 0557-0495 61.343 µM -0.172189199854274 0.459647930775645 no 1830 0.431644394168868 2701 3104427
SGTC_3042 9091578 49.47 µM -0.173293463053234 0.459268061963768 no 1831 0.431210380843611 2686 25236497
SGTC_1159 4092-0538 61.2 µM -0.175059477034399 0.458660626952316 no 1832 0.430516449576112 2728 717301
SGTC_1145 3546-0597 10.2 µM -0.175326169754722 0.458568904154497 no 1833 0.430411674875468 2753 875334
SGTC_1906 st060206 94.7 µM -0.175469003017396 0.458519780861478 no 1834 0.430355562450666 2841 5133468
SGTC_1690 st023502 41.2 µM -0.175951326373748 0.458353904637356 no 1835 0.430166090844201 2814 24207482
SGTC_535 2293-4129 48.2 µM -0.175998825750566 0.458337569479217 no 1836 0.430147432481564 2855 396118 YIL048W NEO1
SGTC_67 0335-0847 266 µM -0.176001581402569 0.458336621805549 no 1837 0.430146350031005 3105 4552207 YOR254C SEC63
SGTC_446 go6976 132 µM -0.177043939665604 0.457978169963923 no 1838 0.429736937915482 2849 3501 A protein kinase C inhibitor.
SGTC_2480 5767542 37.17 µM -0.178823391193066 0.457366321597576 no 1839 0.429038188904153 2772 2867358
SGTC_550 4123-0385 25.7 µM -0.179651021718422 0.457081782638535 no 1840 0.428713273361283 2733 5731123
SGTC_167 3672-0051 66.205 µM -0.17981191273049 0.457026470939031 no 1841 0.428650115523321 2702 3237971
SGTC_2923 7992654 58.14 µM -0.179937303206481 0.456983364320593 no 1842 0.4286008947033 2765 2985126
SGTC_1165 k072-0275 30.3 µM -0.179969046794877 0.456972451620269 no 1843 0.428588434240459 2749 6153523 YGL055W OLE1
SGTC_2097 5376186 200 µM -0.180829660194474 0.456676605332926 no 1844 0.428250640706044 2815 742755
SGTC_1206 3978-0017 132 µM -0.183340164954741 0.455813726674095 no 1845 0.427265560695537 3014 3873677
SGTC_1853 st056710 91.2 µM -0.183878968819608 0.455628562906453 no 1846 0.427054201964661 2904 269167
SGTC_2960 9079389 5.97 µM -0.184524278302271 0.455406810415196 no 1847 0.426801091414418 2864 16457355
SGTC_2 0422-0095 29 µM -0.185134281617979 0.455197203216665 no 1848 0.426561856753951 2688 6790840
SGTC_2453 5731132 22.18 µM -0.185736800951727 0.45499017988098 no 1849 0.426325583725568 2856 1362040
SGTC_2487 5918373 44.05 µM -0.18582390040379 0.454960253852728 no 1850 0.426291430573239 2718 2876279
SGTC_125 0133-0007 11.75 µM -0.186105195406375 0.454863606975344 no 1851 0.426181133873285 2856 26541
SGTC_2869 9037858 32.47 µM -0.187936651653373 0.454234423810554 no 1852 0.425463155382285 2703 27187042
SGTC_3183 9108214 49.47 µM -0.189518749492637 0.453690998249105 no 1853 0.424843130701199 2766 4974831
SGTC_3048 9093155 49.47 µM -0.192212786542605 0.45276583921052 no 1854 0.423787765219203 2759 25236002
SGTC_1194 1488-0194 225 µM -0.192222059123362 0.452762655354158 no 1855 0.423784133705943 2717 1391452
SGTC_3052 9092717 49.47 µM -0.192335020829283 0.452723868786135 no 1856 0.423739893906516 2921 25237534
SGTC_2926 9010726 65.15 µM -0.192977409613133 0.452503306552267 no 1857 0.423488330028777 2855 2994293
SGTC_246 cycloheximide 667 µM -0.194504385577543 0.451979082948064 no 1858 0.422890481054735 2747 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2968 9090663 33.37 µM -0.194959848967506 0.451822734729265 no 1859 0.422712190152254 2847 25236811
SGTC_923 1900-2434 73.3 µM -0.195519739740777 0.45163054966479 no 1860 0.422493042901322 2729 5910570
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.197576763679661 0.450924564473207 no 1861 0.421688108152294 2921 6728940
SGTC_2907 7721985 69.9 µM -0.198193381650031 0.450712966954028 no 1862 0.421446882729669 2806 3267881
SGTC_902 1120-0002 2.07 µM -0.198771277583102 0.450514669933964 no 1863 0.421220832406875 2750 3280475
SGTC_2460 5552655 174.22 µM -0.198792275079919 0.450507465164752 no 1864 0.421212619494457 2871 5401989
SGTC_1017 4239-0030 168 µM -0.19933368334035 0.450321700013532 no 1865 0.421000866165447 2789 1149593
SGTC_810 3825-7150 143 µM -0.199378387531027 0.450306361832911 no 1866 0.420983382670314 2957 22330411 YGL099W LSG1
SGTC_1657 st012939 43.4 µM -0.199937026272234 0.45011469698784 no 1867 0.420764916132112 2911 24207257
SGTC_786 4544-0069 423 µM -0.200313655248484 0.449985484918567 no 1868 0.420617641816544 2886 748821 YLR208W SEC13
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.201642606025695 0.449529597288689 no 1869 0.420098067262058 2912 551469
SGTC_132 0417-1715 25.805 µM -0.201733471507393 0.44949842892213 no 1870 0.420062547023873 2828 6769098
SGTC_482 fipronil 114 µM -0.201976323651335 0.449415128140561 no 1871 0.419967616854545 2736 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1667 st014849 34.6 µM -0.202034755620735 0.449395085707037 no 1872 0.419944776668989 2720 5348460
SGTC_458 nppb 133 µM -0.202251241264537 0.44932083126388 no 1873 0.419860158009479 2930 4549 A chloride channel blocker.
SGTC_620 0109-0052 432 µM -0.202758389278711 0.449146886759047 no 1874 0.419661941431997 2870 493037
SGTC_1678 st019265 80.2 µM -0.204352710657388 0.448600121169509 no 1875 0.419038940888559 2977 5367020
SGTC_493 zm226600 134 µM -0.206374408784674 0.447906929079462 no 1876 0.418249229693966 2955 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2429 5902844 64.44 µM -0.206511163128766 0.447860044994831 no 1877 0.418195822878857 2933 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1520 flindersine 88 µM -0.206531898861782 0.447852936137169 no 1878 0.418187725063307 3051 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.206625789419095 0.447820747727911 no 1879 0.418151058917305 2786 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_621 3584-0052 32.1 µM -0.206802007831955 0.447760335867079 no 1880 0.41808224401289 2806 2273927
SGTC_1250 0485-0349 40.2 µM -0.20762582985769 0.447477926190092 no 1881 0.41776056726459 2794 6842794 YDL195W SEC31
SGTC_1830 st055982 50.3 µM -0.210643109928685 0.44644381821596 no 1882 0.416582885055069 2767 455313 An antimicrobial agent.
SGTC_2023 5144124 124 µM -0.211177732597944 0.446260625545917 no 1883 0.416374292873895 2802 2830192
SGTC_1999 st074831 12.5 µM -0.212675529518934 0.445747454831238 no 1884 0.415790027365504 2808 17112523
SGTC_171 k064-0041 9.68 µM -0.21303635376232 0.445623843855461 no 1885 0.415649303634322 2788 53325
SGTC_6 0844-0013 19.835 µM -0.214217894489043 0.445219109322056 no 1886 0.415188571093173 2830 1584900
SGTC_2252 omeprazole 400 µM -0.215738505008782 0.444698311152807 no 1887 0.414595792624074 2850 4594 A proton pump inhibitor.
SGTC_1751 st044839 27.194 µM -0.218527358305604 0.443743397653185 no 1888 0.413509122259569 2748 5291326
SGTC_897 1000-0139 31.4 µM -0.221332131541703 0.442783362453244 no 1889 0.412416916481005 2952 6151020
SGTC_2759 disulfiram 3.38 µM -0.22142371246472 0.442752021197776 no 1890 0.412381265368229 2782 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3322 9139058 2.11 µM -0.221449255688117 0.44274327973926 no 1891 0.412371321894186 2979 4908926 YPR165W RHO1
SGTC_2594 a-mangostin 100 µM -0.222079423599998 0.442527631116452 no 1892 0.412126027756958 2966 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_270 tamoxifen 5.46 µM -0.222372607995555 0.442427306814021 no 1893 0.412011916831028 2989 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_706 4262-0057 46.9 µM -0.222841572990151 0.442266840106305 no 1894 0.411829405432823 2804 883298
SGTC_949 1165-0505 146 µM -0.223448924094205 0.442059035622743 no 1895 0.411593065396433 2826 6244267
SGTC_3023 9089636 49.47 µM -0.223592715102214 0.442009840026378 no 1896 0.411537116338347 2826 17249241
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.225634371094297 0.441311419747184 no 1897 0.410742902932399 2976 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3151 9099821 49.47 µM -0.226075687019599 0.441160476013511 no 1898 0.410571277014066 2935 17174189
SGTC_1896 st058441 89 µM -0.226996658361085 0.440845502804881 no 1899 0.410213170297289 2825 688759
SGTC_1306 1185-0270 9.02 µM -0.227494495484753 0.440675257530021 no 1900 0.410019624503766 2914 1548076
SGTC_1513 0337-0559 19 µM -0.228931522888595 0.440183899130255 no 1901 0.409461069693229 2826 775073
SGTC_2086 5274770 176.623 µM -0.229061173255087 0.440139572694164 no 1902 0.409410685215747 2886 689278
SGTC_2975 9084847 53.72 µM -0.229206485576305 0.44008989245117 no 1903 0.409354215997747 2910 27211724
SGTC_1748 st037455 53.6035 µM -0.229654932707251 0.439936580622028 no 1904 0.40917995868277 3004 580690
SGTC_1302 1159-0335 255 µM -0.229940412683688 0.439838987503135 no 1905 0.409069036392336 2810 649284
SGTC_2227 7312221 64.1025 µM -0.230130122451229 0.439774136051669 no 1906 0.408995329322764 2817 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1202 1988-0068 29.6 µM -0.230181596597443 0.439756540119334 no 1907 0.408975330862711 2817 2850480
SGTC_1902 st060212 70.5 µM -0.230604922216064 0.439611834922923 no 1908 0.408810871648815 2813 688944
SGTC_323 4013-0906 34.3 µM -0.230780523859505 0.439551811462393 no 1909 0.408742656276531 2912 2910086
SGTC_806 3966-4455 5.86 µM -0.23151204351016 0.439301781270549 no 1910 0.408458515096603 2817 714982
SGTC_2019 4016004 108 µM -0.232028525381708 0.439125264620592 no 1911 0.408257929130556 2883 45595336
SGTC_2815 7968870 71.43 µM -0.233754599240589 0.438535436920026 no 1912 0.407587748836256 2815 2977326 YHR190W ERG9
SGTC_439 amiodarone 34.4 µM -0.239516135367706 0.436567621076245 no 1913 0.405352693156343 2891 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1997 st073024 93.8 µM -0.239757440697211 0.436485238672374 no 1914 0.405259151053901 2950 686268
SGTC_3241 9133421 49.47 µM -0.243042297149081 0.435364053749529 no 1915 0.403986315606027 2863 17018221
SGTC_65 0798-0905 34.986 µM -0.243777622841815 0.435113143724625 no 1916 0.403701525977633 3236 3602145
SGTC_1192 1488-0095 21.4 µM -0.245319541242339 0.434587090676039 no 1917 0.40310451111779 2907 915875
SGTC_1185 1319-0113 81.3 µM -0.246449388130947 0.434201696650404 no 1918 0.402667189348833 2940 4672763
SGTC_137 0438-0332 85.389 µM -0.247408557182902 0.433874570385321 no 1919 0.402296026166381 2855 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2833 9001315 45.46 µM -0.248973435538661 0.433340963221114 no 1920 0.401690664934275 2850 2989378
SGTC_2029 5175081 200 µM -0.25344094769363 0.431818260014238 no 1921 0.399963744286822 2836 1380876
SGTC_754 3474-0146 171 µM -0.254491910597132 0.43146019693919 no 1922 0.399557776414586 2838 24762078
SGTC_561 1550-0330 72.9 µM -0.254572235034583 0.431432832715058 no 1923 0.399526753004608 2863 6812934
SGTC_3171 9103192 49.47 µM -0.255137593588882 0.431240240642866 no 1924 0.399308414620524 2923 13018434
SGTC_75 0159-0059 199.013 µM -0.256308124905678 0.43084154560996 no 1925 0.39885646199448 3167 5377270
SGTC_3157 9099274 49.47 µM -0.257416820841121 0.430463977324766 no 1926 0.398428509572979 2972 17217662
SGTC_598 3937-0236 20.2 µM -0.257918961113718 0.430292993493947 no 1927 0.398234725484341 2933 1379313
SGTC_1283 0922-0125 16.4 µM -0.258285925297693 0.430168046749436 no 1928 0.398093123913048 2979 3360884
SGTC_817 1391-0715 46 µM -0.259859235518944 0.429632433575621 no 1929 0.397486178310872 2908 1353946
SGTC_926 2268-1401 59.4 µM -0.259917372901693 0.429612643928478 no 1930 0.397463755038177 2836 2931578
SGTC_2478 5763493 32.33 µM -0.260283908185054 0.429487881397194 no 1931 0.397322392175642 2855 1365576 YLR208W SEC13
SGTC_2800 7887935 81.82 µM -0.260852441214767 0.429294376121227 no 1932 0.397103150869298 3054 2961002
SGTC_299 1273-0059 1.44 µM -0.262212194736302 0.428831640901623 no 1933 0.396578926097326 2967 2848077
SGTC_43 0570-0105 72.5 µM -0.263557679544605 0.428373857707492 no 1934 0.396060386273348 2875 1114046 YDL195W SEC31
SGTC_64 000l-0018 272.079 µM -0.264094777992636 0.428191144027952 no 1935 0.395853443825789 2829 6811119
SGTC_2582 agaric acid 100 µM -0.264375053544062 0.428095804159014 no 1936 0.395745466133827 2986 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_215 1287-0124 461.5 µM -0.265567083107741 0.427690364647603 no 1937 0.395286319681562 2925 5560863
SGTC_3219 9131112 49.47 µM -0.26648525020331 0.42737812473852 no 1938 0.394932758738736 2959 17612988 YMR079W SEC14
SGTC_2339 9000433 200 µM -0.267008737421234 0.427200123456787 no 1939 0.394731216881048 2925 2988954
SGTC_2737 bleomycin 30.5 nM -0.267624613682008 0.426990726119927 no 1940 0.394494141437522 2898 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_669 0108-0021 26.2 µM -0.26774607971288 0.426949430212982 no 1941 0.394447388906854 3004 17201
SGTC_2687 chenodiol 100 µM -0.268713081972942 0.426620698288424 no 1942 0.394075241991797 2968 5702181 A cholesterol synthesis inhibitor.
SGTC_317 4495-0002 170 µM -0.268767491200812 0.426602203411574 no 1943 0.394054305690315 2922 15991618
SGTC_2393 9031399 185.94 µM -0.269192066310658 0.426457886667857 no 1944 0.393890942591014 3044 1526623 YDL150W RPC53
SGTC_3317 9138495 8.753 µM -0.269474883371377 0.426361760170953 no 1945 0.393782133872629 2881 17020139
SGTC_1650 st011916 45.8 µM -0.269562441646967 0.42633200093521 no 1946 0.393748449099807 2989 242528
SGTC_3100 9120536 49.47 µM -0.271493749858723 0.425675696423307 no 1947 0.393005653073641 2822 16421196
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.272445904827176 0.425352207144547 no 1948 0.392639590076526 2841 688667
SGTC_1670 st016595 4.04 µM -0.276846727484721 0.423857708612445 no 1949 0.390948899767727 2940 597879
SGTC_2546 rhodinyl acetate 100 µM -0.276912511469335 0.42383537693205 no 1950 0.390923642682521 3054 6708682
SGTC_555 4296-0685 37 µM -0.277780271158265 0.423540821587409 no 1951 0.3905905183645 2925 2908540 YHR072W ERG7
SGTC_2507 purpurin 79.67 µM -0.278805587827407 0.423192839630207 no 1952 0.390197012985087 2878 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3301 9125354 19.7965 µM -0.27905152366106 0.42310938042989 no 1953 0.390102642198799 2859 41905162
SGTC_2950 9072895 21.46 µM -0.279330296964221 0.423014781889826 no 1954 0.389995678811656 3032 17332245
SGTC_1498 4478-3555 97.6 µM -0.280125672312383 0.422744904755252 no 1955 0.38969054460273 2906 3437919
SGTC_2761 levamisole 97.89 µM -0.28167208521308 0.422220298530431 no 1956 0.389097480462612 3057 26879 An alkaline phosphatase inhibitor.
SGTC_1273 0849-0096 14.1 µM -0.281963390841219 0.422121491213528 no 1957 0.38898579083646 2935 5286025
SGTC_948 3448-0295 75.3 µM -0.282834388953458 0.421826088535652 no 1958 0.388651895800264 2884 678569
SGTC_130 0136-0219 337.655 µM -0.282895023148001 0.421805525828764 no 1959 0.388628654886588 2857 234244
SGTC_603 3794-0023 45.9 µM -0.283611749262824 0.421562480650487 no 1960 0.388353966040956 3014 3802260
SGTC_1908 st060353 56.5 µM -0.284340699468351 0.421315320873429 no 1961 0.388074649519877 3113 4227716
SGTC_763 3453-1109 128 µM -0.284856993008799 0.421140283774175 no 1962 0.387876853027565 3061 1560353
SGTC_1276 0871-0068 94.2 µM -0.285538374786393 0.420909301279974 no 1963 0.387615854347042 2994 3414906
SGTC_2568 diosmetin 100 µM -0.285907608623927 0.420784145589528 no 1964 0.387474443028436 3081 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_780 0109-0199 192 µM -0.287949412500913 0.420092199585953 no 1965 0.386692731117882 3101 610414
SGTC_1395 3486-0190 4.35 µM -0.290291675847945 0.419298735206465 no 1966 0.385796553259463 3073 6748079
SGTC_478 N-arachidonylglycine 10 µM -0.29123569513435 0.418979032111894 no 1967 0.385435532208751 3001 5283389
SGTC_104 0074-0074 590.992 µM -0.292588900098159 0.418520846885692 no 1968 0.384918199550396 2844 3943124
SGTC_2802 7925815 54.55 µM -0.293504969039957 0.418210735391265 no 1969 0.384568100957881 2905 1262923
SGTC_333 3486-0131 40.1 µM -0.293806411287388 0.418108701006592 no 1970 0.384452917853037 3087 6744690
SGTC_1503 4585-0012 61.3 µM -0.293907297832203 0.418074553418924 no 1971 0.384414370705335 3107 2922052
SGTC_1399 3562-5772 25 µM -0.293942444536027 0.418062657278364 no 1972 0.384400941976014 2877 23847490
SGTC_2451 5856223 45.7 µM -0.29397306613482 0.41805229281581 no 1973 0.384389242296041 2953 2179896
SGTC_2880 9042983 58.44 µM -0.294917474115778 0.41773266794913 no 1974 0.384028461456857 3064 6464714
SGTC_858 0438-0351 2.77 µM -0.294964080431905 0.417716895940892 no 1975 0.384010659604679 2953 2799119
SGTC_2605 digitonin 300 nM -0.297159377943257 0.416974137343711 no 1976 0.383172416745446 3062 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1211 1056-0033 32.3 µM -0.298387278395851 0.416558817608353 no 1977 0.382703798728956 3076 6741922
SGTC_2463 5473429 200 µM -0.300315475713054 0.41590682060406 no 1978 0.38196826491347 2995 5399405
SGTC_1958 st076513 41.9 µM -0.300449848693545 0.415861392581882 no 1979 0.38191702258266 2913 732122 YGL099W LSG1
SGTC_732 3970-1727 52.7 µM -0.301760417607885 0.415418382244295 no 1980 0.38141735359286 3038 1275699
SGTC_1179 1021-1431 9.29 µM -0.302391597672721 0.415205063377339 no 1981 0.381176779605836 3017 2840958
SGTC_1794 st048918 76.9 µM -0.302673785306711 0.415109700977668 no 1982 0.381069238767437 3018 672303
SGTC_3112 9123419 49.47 µM -0.303135614440428 0.414953641379142 no 1983 0.380893256926652 2921 17015854
SGTC_2794 7785382 27.27 µM -0.303739277920413 0.41474967387887 no 1984 0.380663265691202 3005 2205081
SGTC_2093 5331342 194.4 µM -0.304972191506131 0.414333165053469 no 1985 0.380193665996292 3090 33839
SGTC_1421 4029-0249 71.4 µM -0.305684652414263 0.414092521947089 no 1986 0.379922379954269 3096 2894095
SGTC_1565 sinapyl alcohol 95.1 µM -0.306762563851537 0.413728504419146 no 1987 0.379512052476453 3041 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1590 st077108 57.8 µM -0.307614216268739 0.413440948399229 no 1988 0.379187950707399 3047 5489485
SGTC_1506 4226-2149 212 µM -0.308296789342259 0.413210514646382 no 1989 0.37892825444096 3051 991114
SGTC_2368 9071271 200 µM -0.308535041252921 0.413130088854022 no 1990 0.378837620402918 2956 27209959
SGTC_261 5-fluorouridine 15.376 µM -0.309173686023265 0.412914521957204 no 1991 0.378594704737479 3161 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1042 0350-0096 82 µM -0.30985913854186 0.412683184881239 no 1992 0.378334038585961 2936 3122515
SGTC_420 mitomycin C 81.9 mM -0.310222209890272 0.412560662249391 no 1993 0.378195991032093 2947 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3065 9113888 49.47 µM -0.313408133697172 0.411485902018063 no 1994 0.376985302744575 3152 16648368
SGTC_1234 0326-0494 15.5 µM -0.313652972802193 0.411403333771068 no 1995 0.376892310877247 3099 1547813
SGTC_2874 9043904 71.43 µM -0.314857060840523 0.410997330644159 no 1996 0.37643509253522 3018 4463428
SGTC_815 1582-0027 36.9 µM -0.315287353196177 0.41085226464705 no 1997 0.376271743197029 3050 3128206
SGTC_2434 5670830 169.91 µM -0.316921751419799 0.410301365409782 no 1998 0.375651488447954 3070 1549830
SGTC_618 k072-0232 33.2 µM -0.317635537767633 0.410060828117168 no 1999 0.375380706936912 3043 5872756 YGL099W LSG1
SGTC_916 4466-0038 42 nM -0.320927718993642 0.408951842501161 no 2000 0.374132583698441 3182 5722064 YGL116W CDC20
SGTC_1971 st069429 63.5 µM -0.32119989775034 0.408860190379954 no 2001 0.374029454812718 3107 1246522 YGL099W LSG1
SGTC_3049 9092223 49.47 µM -0.321257206908779 0.40884089301383 no 2002 0.374007741446638 3065 8623917
SGTC_580 1123-0028 41 µM -0.321919196151559 0.408618001412162 no 2003 0.373756955124342 2965 1677248 YPR107C YTH1
SGTC_2273 7815444 169.05 µM -0.324332868299691 0.407805569486978 no 2004 0.372843019064336 3154 2824616
SGTC_2327 6189656 200 µM -0.325462998898689 0.407425308264497 no 2005 0.372415341069065 3087 5349088
SGTC_3220 9131269 49.47 µM -0.326572356365774 0.407052121515856 no 2006 0.371995677264201 2991 17722206
SGTC_1564 D-Arginine 115 µM -0.327091420137534 0.406877537931574 no 2007 0.371799370479207 3021 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1439 4092-1168 46 µM -0.327646515307505 0.406690855905901 no 2008 0.371589473714904 3042 2886240
SGTC_3054 9094397 49.47 µM -0.327862998631687 0.406618056935656 no 2009 0.371507625753697 3006 2598354
SGTC_954 1189-0853 2.85 µM -0.328086391120118 0.406542937936315 no 2010 0.371423171667598 2970 2828194
SGTC_1196 1588-0294 184 µM -0.328308430959274 0.406468277193034 no 2011 0.371339235087397 3032 6144269
SGTC_2342 7990637 118.86 µM -0.329314309506896 0.406130093853027 no 2012 0.37095906468257 3097 2033102 YER133W GLC7
SGTC_1828 st055811 49 µM -0.33099147606731 0.405566374661738 no 2013 0.370325462063951 3132 5877589
SGTC_2000 st075254 36.4 µM -0.331901194248954 0.405260687460065 no 2014 0.369981934291218 2989 17234175
SGTC_136 0097-0015 404.482 µM -0.332731191327198 0.404981838873497 no 2015 0.369668601268314 3045 4861337
SGTC_2265 7929201 200 µM -0.333315150913196 0.404785678762851 no 2016 0.369448201942956 2936 1265108
SGTC_1345 1488-0192 31.4 µM -0.334909291355711 0.404250306856658 no 2017 0.368846756489555 3144 658348
SGTC_647 0140-0236 81 µM -0.335339489236255 0.404105861013512 no 2018 0.368684504182988 3036 990837
SGTC_1822 st052468 42 µM -0.335757780525159 0.403965425535 no 2019 0.368526764977616 3055 2873678
SGTC_2125 5246583 200 µM -0.336573826761534 0.403691485011458 no 2020 0.368219094684104 3154 835267
SGTC_759 3486-0358 89.3 µM -0.338549648380029 0.4030284125938 no 2021 0.367474509726297 3177 875103
SGTC_2552 juarezic acid 87.02 µM -0.339486166362884 0.402714220730587 no 2022 0.367121758316404 2963 1549512
SGTC_3266 9136860 49.47 µM -0.340656732405753 0.402321596573078 no 2023 0.366681007431462 3098 4871271 YPR165W RHO1
SGTC_2282 7944268 200 µM -0.342126229818772 0.401828846185091 no 2024 0.366127949341566 3206 2970414
SGTC_2595 hexamethylquercetagetin 100 µM -0.343683181246845 0.401306941036587 no 2025 0.365542280487362 3057 386331
SGTC_1630 st005209 31.3 µM -0.343993141520555 0.401203060342229 no 2026 0.365425721990894 3086 3367314
SGTC_1000 4048-0884 8.67 µM -0.344076716015294 0.401175052217107 no 2027 0.365394296485493 3127 13040088
SGTC_126 0417-1624 672.48 µM -0.346351280431621 0.400412978214117 no 2028 0.364539367188164 3137 41912 YDL195W SEC31
SGTC_1166 k206-0078 225 µM -0.346732837500946 0.400285177712177 no 2029 0.364396019051517 2996 5404595
SGTC_988 1497-1057 103 µM -0.34705521368157 0.400177207853097 no 2030 0.364274919510922 3093 3533044
SGTC_278 4092-0821 23.9 µM -0.347453436148441 0.400043846176845 no 2031 0.364125347270595 3096 877900
SGTC_499 genistein 192 µM -0.348308250987996 0.399757614571322 no 2032 0.363804348984794 3090 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_635 k038-0028 24.7 µM -0.348958428788774 0.399539940978423 no 2033 0.363560259545253 3061 4035102
SGTC_2335 9018011 154.17 µM -0.349318661120993 0.399419351919123 no 2034 0.363425045128484 3107 6458208
SGTC_708 3448-5400 146 µM -0.349402411535424 0.399391317543217 no 2035 0.363393611565922 3123 3462195
SGTC_352 k048-0007 5.11 µM -0.349814423938639 0.399253409237735 no 2036 0.363238986711148 3116 6811911
SGTC_1810 st050138 53 µM -0.35103398308566 0.398845273583246 no 2037 0.362781426919295 3153 3444541
SGTC_435 c-PAF 6.7 µM -0.351542373927636 0.398675168972729 no 2038 0.362590744314479 3162 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1472 k841-0093 193 µM -0.351682755579732 0.398628201480388 no 2039 0.362538097245443 3145 X1472
SGTC_822 1487-0950 154 µM -0.352244865036677 0.398440151222655 no 2040 0.362327316433507 3185 1958375
SGTC_570 0987-0065 62.6 µM -0.352727641560244 0.398278660131146 no 2041 0.362146317336677 2979 3104428
SGTC_2281 7943571 200 µM -0.354018919667157 0.39784680701711 no 2042 0.361662352208122 3254 1244024
SGTC_2888 9058547 12.99 µM -0.35598498551219 0.397189519375399 no 2043 0.360925904726813 3024 16476514
SGTC_3086 9117350 49.47 µM -0.356252067217791 0.39710025211502 no 2044 0.360825901156661 3093 2679265
SGTC_1986 st071812 45 µM -0.357963206583434 0.396528462624461 no 2045 0.360185424194924 3117 11838594
SGTC_1952 st077036 64.1 µM -0.358111553367887 0.396478901943765 no 2046 0.360129916661198 3009 2937007
SGTC_2840 9008771 71.43 µM -0.358902186281458 0.396214790270693 no 2047 0.359834132016638 3128 2992978
SGTC_2583 asiatic acid 100 µM -0.358972868733755 0.396191181048074 no 2048 0.359807693002305 3215 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_17 0960-0276 49.807 µM -0.359047952964403 0.396166101968579 no 2049 0.359779608222442 3044 6821114
SGTC_1150 3909-7983 10.9 µM -0.361165458885022 0.39545900561229 no 2050 0.358987880849133 3065 23965914
SGTC_742 0kpi-0133 140 µM -0.361978343217209 0.395187651318397 no 2051 0.358684107108629 3193 2728852
SGTC_789 1309-1135 70.6 µM -0.363422435609014 0.39470571469793 no 2052 0.358144672318883 3026 3092424
SGTC_3292 9120825 59.784 µM -0.364187974221938 0.394450296959031 no 2053 0.357858823236573 3212 24824900
SGTC_459 nigericin 15.3 µM -0.364397301329548 0.394380464018359 no 2054 0.357780675191704 3183 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_645 0845-0943 5.41 µM -0.365018252071839 0.394173330624 no 2055 0.357548890860953 3096 1885106
SGTC_1799 st045822 46.1415 µM -0.365272608727509 0.394088492341613 no 2056 0.357453961474941 3188 3674992
SGTC_1578 josamycin 24.2 µM -0.366491494924752 0.393682014062546 no 2057 0.356999178947552 3053 5282165 A P450 substrate.
SGTC_2523 spermine 47.74 µM -0.370567608109179 0.39232354174476 no 2058 0.355479805967167 3154 1103 A DNA binding polyamine.
SGTC_140 0062-0056 502.533 µM -0.370632625012034 0.392301883725766 no 2059 0.355455589411361 3011 3758964
SGTC_2849 9019321 12.99 µM -0.37209787381989 0.391813877916259 no 2060 0.354909989656524 3169 16489627
SGTC_16 erodoxin 22.806 µM -0.374157003060999 0.391128366077606 no 2061 0.354143755549345 3191 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1651 st011928 86.1 µM -0.374690915511971 0.390950674547919 no 2062 0.353945174627859 3159 720198
SGTC_1716 st033144 30.6155 µM -0.37550761542623 0.390678912509222 no 2063 0.353641491917991 3226 674617
SGTC_869 0564-0080 44.1 µM -0.375514711370043 0.39067655152301 no 2064 0.35363885376123 3095 6843321
SGTC_271 rotenone 740 µM -0.375674757185781 0.390623301613461 no 2065 0.353579353191591 3186 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.379011498468126 0.389513580810623 no 2066 0.352339662609842 3209 5282362
SGTC_2110 5483698 200 µM -0.379652668368041 0.389300445790797 no 2067 0.352101629563634 3091 2848765 YHR062C RPP1
SGTC_1938 st074717 56.4 µM -0.381769035413459 0.388597168579413 no 2068 0.351316344201239 3021 17250979
SGTC_86 0417-1630 471.922 µM -0.382115025847041 0.388482229230944 no 2069 0.3511880234843 3162 3634867
SGTC_1733 st037357 54.9 µM -0.382992948472247 0.388190623811335 no 2070 0.350862496250285 2987 1272339 YGL099W LSG1
SGTC_3017 9080681 49.47 µM -0.383037584598226 0.388175799430444 no 2071 0.350845948425666 3150 16451914
SGTC_644 1498-1197 63.3 µM -0.386980557086178 0.386866919583126 no 2072 0.349385300970093 3185 6741615
SGTC_1620 st003704 16.5 µM -0.387372034288222 0.386737037636574 no 2073 0.349240402107339 3221 2834414
SGTC_636 0kpi-0074 126 µM -0.389015650595846 0.386191867110441 no 2074 0.348632284497561 3141 616434
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.391328299422681 0.38542516601135 no 2075 0.34777729172334 3272 5393153
SGTC_693 4161-2696 114 µM -0.391343082756684 0.385420266401729 no 2076 0.347771828766874 3195 805759
SGTC_2040 5100729 123 µM -0.391985630716189 0.385207325749593 no 2077 0.347534415485156 3084 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2362 9071156 126 µM -0.392820167152716 0.384930811710218 no 2078 0.347226154176024 3236 653133
SGTC_2697 mebhydrolin 72.4 µM -0.393970853221869 0.384549641113614 no 2079 0.346801279165923 3268 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3213 9129884 49.47 µM -0.395313274560926 0.384105098282744 no 2080 0.346305851948476 3160 17190742
SGTC_292 k038-0015 474 µM -0.396625893553665 0.38367057187427 no 2081 0.345821677582557 3200 46368540
SGTC_332 4112-0506 40.9 µM -0.398697025803703 0.382985246574914 no 2082 0.345058229811175 3103 2790355
SGTC_3076 9116187 49.47 µM -0.398996519172405 0.382886176256358 no 2083 0.344947884530404 3200 27241210
SGTC_2735 sertaconazole 140 nM -0.400113723775376 0.382516680404233 no 2084 0.344536378271613 3163 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2452 5863136 48.41 µM -0.400576245828948 0.382363740615389 no 2085 0.344366068724765 3069 2184096
SGTC_1375 2910-0797 186 µM -0.401949898766346 0.381909630117767 no 2086 0.343860449319762 3143 742508
SGTC_3008 9078912 71.4286 µM -0.40221140072231 0.381823199605357 no 2087 0.343764226282343 3118 16648731
SGTC_1243 0416-0003 5.65 µM -0.40228143501457 0.38180005316932 no 2088 0.343738457973749 3108 2141977
SGTC_1927 st060202 13.8 µM -0.402616761495993 0.381689233133576 no 2089 0.343615088530999 3249 688887
SGTC_821 1114-0266 29.2 µM -0.403261450737093 0.381476200904835 no 2090 0.343377948718199 3195 3123235
SGTC_202 3594-0513 34.79 µM -0.404434367867765 0.381088712254234 no 2091 0.342946665906428 3134 708429
SGTC_551 k048-0028 34.9 µM -0.405894531949717 0.380606494381816 no 2092 0.342410047966462 3253 6836383
SGTC_3043 9092303 49.47 µM -0.406907586840108 0.380272042827956 no 2093 0.342037931752239 3167 25236084
SGTC_1434 4073-0095 163 µM -0.410406273509092 0.379117670536557 no 2094 0.340753972513427 3232 24133745
SGTC_2998 9066762 71.4286 µM -0.414994434040958 0.377605466164875 no 2095 0.339072988849657 3317 4945196
SGTC_600 1495-0418 41.6 µM -0.415093918492921 0.377572697923266 no 2096 0.339036575625758 3131 5377768
SGTC_301 4119-0100 24.5 µM -0.416272968842692 0.377184408861063 no 2097 0.338605135103588 3160 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1016 4226-1401 38 µM -0.416668162459191 0.37705429005034 no 2098 0.338460572391289 3221 2901613
SGTC_1432 4049-0298 68.4 µM -0.418247943901184 0.376534281343813 no 2099 0.337882922733536 3230 741646
SGTC_359 0081-0058 15.9 µM -0.418891433985538 0.376322531093241 no 2100 0.337647738829537 3476 3494159
SGTC_3068 9116768 49.47 µM -0.422002328295993 0.375299369708266 no 2101 0.336511659001037 3245 41904888
SGTC_807 1315-0151 48 µM -0.422560805512086 0.375115781271669 no 2102 0.336307864035383 3344 4011080
SGTC_1163 k060-0048 49.9 µM -0.42305492766002 0.374953371887109 no 2103 0.336127593091658 3147 6809982
SGTC_825 1988-2224 89.6 µM -0.423327307251275 0.374863854914607 no 2104 0.336028236754534 3151 1180859
SGTC_2022 5136654 200 µM -0.423948064345145 0.37465986961422 no 2105 0.335801845014564 3261 1713771
SGTC_696 1560-0013 611 µM -0.424084043838488 0.374615190443082 no 2106 0.335752260888216 3333 1650269
SGTC_146 3448-8650 53.125 µM -0.424335894139985 0.374532443715336 no 2107 0.335660432702444 3149 2891488 YIL048W NEO1
SGTC_2969 9091408 28.7 µM -0.424615257572282 0.374440664164346 no 2108 0.335558584319496 3108 4286311
SGTC_255 tunicamycin 200.472 nM -0.425356991073322 0.374197016238369 no 2109 0.33528822689967 3202 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1355 1499-0035 1.68 µM -0.425861618002146 0.374031282846969 no 2110 0.335104342146573 3137 1548538
SGTC_716 1683-5115 658 µM -0.425891815678235 0.374021365835886 no 2111 0.335093339443808 3222 723597
SGTC_183 3914-0051 30.55 µM -0.426234013101818 0.373908992961233 no 2112 0.334968667667823 3275 1596232
SGTC_1460 k062-0059 9.15 µM -0.426366271396356 0.373865564047429 no 2113 0.334920487265482 3052 1373085
SGTC_2156 5649887 115 µM -0.426417430926162 0.373848765509245 no 2114 0.334901851078125 3245 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1140 3229-1848 2.98 µM -0.426611967071116 0.373784890588463 no 2115 0.334830989947696 3256 2849525
SGTC_450 aminopyrene 156 nM -0.428736361437065 0.373087582824453 no 2116 0.334057547892877 3257 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1700 st030840 7.9285 µM -0.430418623252632 0.372535694605024 no 2117 0.333445575332583 3248 5499307
SGTC_3108 9121785 49.47 µM -0.432358384243968 0.371899655159479 no 2118 0.33274047975636 3236 17140271
SGTC_795 0685-0265 78 µM -0.432486073920652 0.371857798492979 no 2119 0.332694085767818 3243 302754
SGTC_3225 9130819 49.47 µM -0.432519364926353 0.37184688595268 no 2120 0.332681990437826 3281 4547121
SGTC_1119 parthenolide 318.541 nM -0.433442505277294 0.371544328554986 no 2121 0.332346663337162 3346 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_122 0236-0016 402.397 µM -0.43404945501407 0.371345445216145 no 2122 0.332126264313296 3216 6808838
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.434086719991074 0.371333235466865 no 2123 0.332112734334897 3152 688803
SGTC_2914 7968218 45.32 µM -0.434640061286948 0.371151950221716 no 2124 0.33191185575175 3225 2977111
SGTC_1493 4348-0038 111 µM -0.435419971921503 0.370896485054674 no 2125 0.33162880810951 3264 800424
SGTC_2847 9005661 71.43 µM -0.43542180863436 0.370895883493679 no 2126 0.331628141637227 3238 2991449
SGTC_2722 naftopidil 47.16 µM -0.438325620697876 0.3699452211913 no 2127 0.330575127941266 3285 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2421 5690543 90.72 µM -0.438741042228891 0.369809283529197 no 2128 0.330424592362247 3267 3397993
SGTC_2537 larixol 68.93 µM -0.439103761885391 0.369690604711386 no 2129 0.33029317670388 3270 6708759
SGTC_2641 levomentholum 100 µM -0.439997889386339 0.369398106751686 no 2130 0.329969317987778 3236 16666
SGTC_3285 9112818 20.8695 µM -0.441393728408876 0.368941633909404 no 2131 0.329463990875485 3185 17017947 YPR165W RHO1
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.442215141974171 0.368673098297944 no 2132 0.329166764938279 3322 688664
SGTC_2769 toremifene 3.73 µM -0.443330376661002 0.368308609646973 no 2133 0.328763393544528 3361 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3094 9117742 49.47 µM -0.445172529726546 0.367706804181743 no 2134 0.328097538505782 3144 17149698
SGTC_1056 3448-1962 115 µM -0.448250022540906 0.366702155472967 no 2135 0.326986382507845 3255 715507
SGTC_1829 berberine 14.4 µM -0.449436067788404 0.366315213762972 no 2136 0.326558558843894 3326 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_956 1185-0240 191 µM -0.450649718058736 0.365919406697518 no 2137 0.326121013665756 3182 1416193
SGTC_3149 9097855 49.47 µM -0.451821794710414 0.365537293417752 no 2138 0.32569868369161 3312 25236625 YMR079W SEC14
SGTC_2400 5203494 178.7 µM -0.456447008861437 0.364030714502856 no 2139 0.324034284180085 3279 6777674
SGTC_351 caspofungin 25 nM -0.458107417401703 0.363490377602248 no 2140 0.323437635114458 3222 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1115 galangin 695.678 nM -0.458847435170849 0.363249645398992 no 2141 0.323171864158018 3365 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2928 9011484 9.79 µM -0.458952062774968 0.363215613769528 no 2142 0.323134295340118 3302 2994751
SGTC_2648 atorvastatin 78.68 µM -0.459882052020962 0.362913168905981 no 2143 0.322800441783134 3310 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_110 0850-0284 111.64 µM -0.460622131265681 0.362672546371477 no 2144 0.322534865339429 3109 3906265
SGTC_676 falcarinol 140 µM -0.461437617114801 0.362407469623446 no 2145 0.322242334164472 3388 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1033 k072-0102 21.3 µM -0.46430463112052 0.361476060200855 no 2146 0.321214753231726 3331 5965931
SGTC_666 0272-0154 136 µM -0.46462877677474 0.361370806224483 no 2147 0.321098660443639 3262 6870312
SGTC_2790 5423970 71.43 µM -0.466141434538758 0.360879766965533 no 2148 0.320557133276641 3350 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1636 st007707 68.9 µM -0.466226359425043 0.360852205421045 no 2149 0.320526741716933 3406 403051
SGTC_2111 5486399 200 µM -0.466709611975251 0.360695384272813 no 2150 0.32035382593547 3257 689674
SGTC_3259 9138485 49.47 µM -0.467114947686531 0.360563866118204 no 2151 0.320208820161313 3485 17646153
SGTC_2444 5485484 36.41 µM -0.467269909266768 0.360513590520863 no 2152 0.32015339108495 3314 6790631
SGTC_508 roscovitine 141 µM -0.467933315720317 0.360298382788686 no 2153 0.319916138893834 3285 160355 A CDKinase inhibitor.
SGTC_290 2043-6722 48.1 µM -0.46808378763388 0.360249576154728 no 2154 0.319862336287559 3312 773758 YLR208W SEC13
SGTC_3302 9125395 16.351 µM -0.472584249835443 0.358790875212333 no 2155 0.318254910727873 3228 17599668
SGTC_2206 7254556 146.969 µM -0.47476500257565 0.358084782781654 no 2156 0.317477240255415 3266 4398905
SGTC_739 1486-1183 203 µM -0.474842293964227 0.358059765969583 no 2157 0.317449692398017 3341 4346692
SGTC_973 1325-0077 65.9 µM -0.47604725618258 0.357669836151684 no 2158 0.317020355876325 3260 2835149
SGTC_1029 k015-0030 64.7 µM -0.476141254266929 0.3576394242951 no 2159 0.316986874043119 3330 2208316
SGTC_1985 st071382 65.5 µM -0.478293463601999 0.356943352587335 no 2160 0.316220673987294 3303 6123237
SGTC_2249 haloperidol 116.36 µM -0.478860987777298 0.356759882029365 no 2161 0.31601876304427 3302 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1813 st051246 8.6015 µM -0.479721433594205 0.356481778277373 no 2162 0.315712742555219 3307 5291959
SGTC_1114 scopoletin 1.73284 µM -0.480319355636367 0.356288569467088 no 2163 0.315500163903232 3359 5280460 A coumarin with genotoxic properties.
SGTC_2027 5150920 200 µM -0.481207879804122 0.356001525437916 no 2164 0.315184380526674 3265 786715
SGTC_377 3970-0964 33.1 µM -0.481391560520083 0.355942196253857 no 2165 0.315119116840996 3296 16481235
SGTC_1348 1493-0373 93.8 µM -0.481707796408045 0.355840059697255 no 2166 0.315006768432473 3281 3010129
SGTC_3203 9113543 49.47 µM -0.483892483084317 0.355134741649266 no 2167 0.314231087685903 3343 17018012
SGTC_1347 1493-0251 600 nM -0.484060171177983 0.355080624634329 no 2168 0.314171583266125 3350 3986378
SGTC_1510 1123-0200 71.5 µM -0.485424659320503 0.354640379968997 no 2169 0.313687571869587 3443 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_527 4476-4215 268 µM -0.48722219607934 0.354060710853145 no 2170 0.313050438716535 3239 4418754
SGTC_201 4262-0159 12.803 µM -0.487505031371599 0.353969532959422 no 2171 0.312950239082097 3278 1341029
SGTC_1708 st033234 31.827 µM -0.488092654247633 0.353780127165566 no 2172 0.312742106981912 3389 674664
SGTC_3204 9114183 49.47 µM -0.489700840536358 0.353261952990051 no 2173 0.312172803493086 3202 17027248
SGTC_1953 st076800 12.1 µM -0.489908341380014 0.353195113868246 no 2174 0.312099380099229 3273 297591
SGTC_2226 7298446 200 µM -0.490270741450637 0.353078390253116 no 2175 0.311971164097858 3340 3283010
SGTC_2182 6325192 200 µM -0.490624745231226 0.352964384302662 no 2176 0.311845940670447 3345 736248
SGTC_285 1486-1325 46 µM -0.490985877801289 0.352848096145194 no 2177 0.311718217951395 3368 22310230
SGTC_2338 7999974 200 µM -0.491815268364464 0.352581076465317 no 2178 0.311424970923246 3290 315925
SGTC_349 k015-0014 24 µM -0.492118517676901 0.352483464427815 no 2179 0.311317781129932 3205 2196908
SGTC_1359 1582-0056 520 nM -0.492842424176133 0.35225048755683 no 2180 0.311061965962248 3357 3661189
SGTC_624 k048-0052 28 µM -0.494845317745347 0.351606179770406 no 2181 0.31035465623646 3276 6835531
SGTC_3175 9106517 49.47 µM -0.494890457865879 0.351591663616231 no 2182 0.310338723342175 3346 41468073
SGTC_3179 9107801 49.47 µM -0.497095682142674 0.35088277176747 no 2183 0.309560789685137 3278 4818259
SGTC_263 alizarin 107.927 µM -0.498061852266548 0.350572349798302 no 2184 0.309220223646409 3313 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2129 girgensonine 121.053 µM -0.499368196296778 0.350152791591591 no 2185 0.308760010026111 3295 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2305 7443522 69.23 µM -0.499598256871445 0.350078922010445 no 2186 0.308678992754582 3317 5415886
SGTC_1571 st070080 73.4 µM -0.499625604819666 0.350070141302545 no 2187 0.308669362622584 3422 4315245
SGTC_987 1497-1013 404 µM -0.499930940796777 0.349972111384364 no 2188 0.308561852496686 3367 1676435
SGTC_1279 0874-0590 65.2 µM -0.502025749854533 0.349299830475467 no 2189 0.307824703996325 3322 3523074
SGTC_1087 pterostilbene 9.05 µM -0.503645919371576 0.348780198174135 no 2190 0.307255109037493 3393 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1431 4049-0260 9.09 µM -0.504123929591395 0.348626941455743 no 2191 0.307087146063239 3330 3854841
SGTC_1898 st060199 18.6 µM -0.504794526727142 0.348411980333928 no 2192 0.306851580221006 3315 688866
SGTC_2253 7938677 135.83 µM -0.505271655440193 0.34825906549689 no 2193 0.306684024067256 3417 2301972
SGTC_584 0986-0246 15.4 µM -0.5057180522616 0.348116022245318 no 2194 0.306527296786835 3411 53315 YDR232W HEM1
SGTC_1946 st076057 65.1 µM -0.506318407524655 0.347923678673347 no 2195 0.306316571396923 3307 953009
SGTC_2515 chrysin 20.77 µM -0.506508011661768 0.347862940873492 no 2196 0.306250033430657 3341 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1008 4106-0037 6 µM -0.507801345173639 0.347448738548502 no 2197 0.305796333169131 3353 2905394
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.507920201346757 0.347410682860206 no 2198 0.305754653464254 3341 6312947
SGTC_3247 9135149 49.47 µM -0.508663016956352 0.347172881023246 no 2199 0.305494224765751 3315 8934436 YOR116C RPO31
SGTC_1606 st000094 49.2 µM -0.508786697957629 0.347133292152277 no 2200 0.305450872166697 3419 1242210
SGTC_2497 7-hydroxyflavone 100 µM -0.509043407611258 0.347051127659273 no 2201 0.305360899142603 3399 5281894
SGTC_2432 5630864 12.22 µM -0.513435191731683 0.345646575543978 no 2202 0.303823466957443 3402 5714970
SGTC_2948 9070189 9.45 µM -0.514489017609031 0.345309862706355 no 2203 0.303455068387 3365 6473636 YDL196W YDL196W
SGTC_1745 st081495 74 µM -0.515202697717012 0.345081900930654 no 2204 0.303205692048131 3383 13842402 YBL026W LSM2
SGTC_495 decylubiquinone 155 µM -0.515954293906157 0.344841888868922 no 2205 0.302943166066692 3353 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_473 2-arachidonoylglycerol 10 µM -0.51779093030689 0.344255646733747 no 2206 0.302302073504152 3261 5282280 An endocannabinoid.
SGTC_3011 9081274 71.4286 µM -0.522477196855855 0.342761519097288 no 2207 0.300669059650182 3323 6625322
SGTC_3139 9095020 49.47 µM -0.522504322897858 0.342752877598904 no 2208 0.300659618692771 3277 25236292
SGTC_3105 9121040 49.47 µM -0.522820450681288 0.342652175361141 no 2209 0.300549603333225 3323 41448907
SGTC_1122 capsaicin 818.572 nM -0.523156057151256 0.342545280440207 no 2210 0.300432829109385 3417 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_205 1486-1330 71.903 µM -0.523214126686986 0.342526785835335 no 2211 0.300412625902857 3374 4118834
SGTC_564 3555-0129 330 µM -0.523259875397595 0.342512215564091 no 2212 0.3003967097166 3364 563260
SGTC_1378 2093-0007 380 nM -0.524600907776291 0.342085221264554 no 2213 0.29993032777621 3388 3618014
SGTC_231 b-estradiol 524 µM -0.526403098141821 0.341511708947334 no 2214 0.299304081776232 3287 450 A steroid.
SGTC_1454 4239-0054 42.6 µM -0.528646711169543 0.340798233551127 no 2215 0.298525275091265 3502 1340767
SGTC_1314 1222-0010 41.1 µM -0.529191215545985 0.340625165315844 no 2216 0.298336404929748 3359 3526027
SGTC_2050 5263056 171 µM -0.529549744958049 0.340511226690911 no 2217 0.298212072904646 3421 763468 YGL055W OLE1
SGTC_397 arbidol 50 µM -0.531268631833895 0.339965176447766 no 2218 0.297616319625703 3438 131410 A RNA synthesis inhibitor.
SGTC_229 benomyl 22.8748 µM -0.532033501716852 0.339722302948599 no 2219 0.297351396219071 3409 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2435 5706476 10.6 µM -0.535131016324045 0.338739412606488 no 2220 0.29627963186708 3451 5725375
SGTC_2912 7964298 10.93 µM -0.535698549615052 0.338559444051658 no 2221 0.296083453089792 3416 2975850
SGTC_2415 st077333 57.7 µM -0.535736190315814 0.338547509239857 no 2222 0.296070443967209 3519 2766255
SGTC_990 3985-0011 41.3 µM -0.536797753712151 0.338210984034906 no 2223 0.295703661733457 3342 5399565 YGL099W LSG1
SGTC_1277 0873-0036 22 µM -0.538364562920551 0.337714527485091 no 2224 0.295162693195311 3436 5965735
SGTC_1 0258-0098 57.368 µM -0.53920619487562 0.337447965856279 no 2225 0.294872293157173 3345 6790032 YDR047W HEM12
SGTC_2416 tofa 880 nM -0.54054309393051 0.337024710957328 no 2226 0.294411275118699 3292 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2189 6047310 154.431 µM -0.540789124080773 0.336946841618069 no 2227 0.294326470022747 3373 711535
SGTC_2083 5306046 65.942 µM -0.542984917321356 0.33625217576005 no 2228 0.293570093575193 3389 539837
SGTC_536 3852-0578 10.6 µM -0.543507589677684 0.336086904250612 no 2229 0.293390183344015 3467 2869208
SGTC_1013 4112-3890 241 µM -0.545418462019615 0.335482947085514 no 2230 0.292732872845848 3280 705171
SGTC_2296 7971656 126.45 µM -0.545744814156004 0.335379841492839 no 2231 0.292620681173017 3396 666570
SGTC_1852 st056254 31.4 µM -0.548701190502638 0.334446388660799 no 2232 0.291605264528273 3327 442583
SGTC_465 cgp-37157 41 µM -0.550620356753883 0.333840973812411 no 2233 0.290946975555524 3361 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1612 st002233 45.4 µM -0.55132616640781 0.333618429697674 no 2234 0.290705052124832 3466 1035021
SGTC_1930 st074634 34.3 µM -0.553275569048989 0.33300408087104 no 2235 0.290037363790509 3382 684253 YOR116C RPO31
SGTC_95 0471-0001 561.058 µM -0.556524036045353 0.331981331274994 no 2236 0.288926333850839 3402 4015405
SGTC_1061 3448-9325 110 µM -0.557366808752608 0.331716196135773 no 2237 0.288638419039447 3463 723482
SGTC_654 1124-0271 80.9 µM -0.557400379669675 0.33170563651577 no 2238 0.28862695307126 3390 5403748
SGTC_688 0527-0193 473 µM -0.557478260813969 0.331681139776539 no 2239 0.288600354006862 3367 4007154
SGTC_2317 5986382 200 µM -0.557516035774881 0.331669258297562 no 2240 0.288587452986514 3479 877883
SGTC_2518 prenyletin 46.28 µM -0.558037124686332 0.331505375824444 no 2241 0.28840951683531 3405 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1301 naphtanilide LB 4.81 µM -0.558626279490269 0.331320125474031 no 2242 0.288208400547677 3497 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2360 9040895 200 µM -0.561151422584113 0.330526602377404 no 2243 0.287347157687198 3393 4914414
SGTC_753 1322-0200 289 µM -0.561572990414988 0.330394199267647 no 2244 0.287203493521936 3502 5403907
SGTC_180 1486-1293 102.781 µM -0.56229563804649 0.33016728448832 no 2245 0.286957304875243 3532 4140536
SGTC_2810 7959871 45.46 µM -0.563731694277819 0.329716541462468 no 2246 0.286468372043759 3419 2974535
SGTC_2845 9003024 42.97 µM -0.56430363415645 0.329537092280181 no 2247 0.28627375429474 3545 2990173
SGTC_660 4031-1742 102 µM -0.56537167785807 0.329202092977431 no 2248 0.28591049220523 3403 6738706
SGTC_3252 9135871 49.47 µM -0.565777675059507 0.329074785090328 no 2249 0.285772462299294 3485 17682838
SGTC_1851 st056236 18.9 µM -0.565792932180702 0.329070001325812 no 2250 0.285767275839625 3518 5393171
SGTC_1287 0971-0001 34.6 µM -0.568636143190516 0.328179021620371 no 2251 0.284801545733258 3480 4665869
SGTC_1803 st050068 52.4 µM -0.570413131222258 0.327622660780333 no 2252 0.284198762703047 3539 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1482 3346-2049 8.48 µM -0.570419051964946 0.327620807681538 no 2253 0.284196755311577 3458 3826804
SGTC_591 4299-0174 154 µM -0.570602934363394 0.327563257513786 no 2254 0.284134414488107 3388 5509088
SGTC_2373 9071805 200 µM -0.570674215297354 0.327540949630365 no 2255 0.284110250192372 3484 10149009
SGTC_864 0469-0573 172 µM -0.57142181074852 0.327307021334782 no 2256 0.283856873945581 3399 689425
SGTC_1444 4112-3581 28 µM -0.57170828663738 0.327217398817646 no 2257 0.283759809753165 3488 2877249
SGTC_1605 st000082 49.1 µM -0.574478443398324 0.326351283931074 no 2258 0.282822041888321 3476 1114022
SGTC_2915 7971052 15.16 µM -0.576366650224036 0.325761454589004 no 2259 0.282183690624581 3400 5741558
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.576429676533721 0.325741774230546 no 2260 0.282162395113598 3474 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2581 avocatin a 64 µM -0.577735287849647 0.325334198247117 no 2261 0.281721425497564 3418 6710728 A skin care supplement.
SGTC_2621 lithochol-11-enic acid 100 µM -0.582934229959486 0.323713306653937 no 2262 0.279968788221959 3511 6708711
SGTC_1710 st031758 61.5 µM -0.584851898999636 0.323116269632809 no 2263 0.279323651996781 3543 5394341
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.5848527998799 0.323115989264372 no 2264 0.279323349095276 3527 7104
SGTC_2566 crystal violet carbinol 226 nM -0.585039288918188 0.323057953038121 no 2265 0.279260649625578 3472 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2913 7966556 36.57 µM -0.588072335967546 0.322114660731367 no 2266 0.278241870376535 3479 2976516
SGTC_799 1310-0557 151 µM -0.589250080465235 0.321748684700211 no 2267 0.27784676327721 3537 5354492
SGTC_1702 st027038 51 µM -0.589295277662149 0.321734643423357 no 2268 0.277831606081382 3494 5521182
SGTC_3240 9133527 49.47 µM -0.589369412361811 0.321711612771101 no 2269 0.277806745365942 3481 17617455
SGTC_1948 st076329 66.6 µM -0.590898590563971 0.321236711873932 no 2270 0.277294185210413 3433 24208413
SGTC_417 st075190 100 µM -0.591533527509584 0.321039611933192 no 2271 0.277081498777018 3547 222757
SGTC_2235 salicylic acid 500 µM -0.592082447759048 0.320869254304201 no 2272 0.276897689942006 3486 338 A COX inhibitor and kinase inhibitor.
SGTC_3018 9082602 49.47 µM -0.593272776778322 0.320499964777171 no 2273 0.27649930724756 3514 17332089
SGTC_3082 9117008 49.47 µM -0.593282826199334 0.320496847784851 no 2274 0.276495945075492 3453 41448529
SGTC_694 1315-0438 43.2 µM -0.593363057950458 0.320471963048809 no 2275 0.276469103158147 3428 6793154
SGTC_2205 7238770 200 µM -0.593604229409075 0.320397166000132 no 2276 0.276388425783306 3525 279867
SGTC_2302 7771753 200 µM -0.594448218894543 0.320135468088819 no 2277 0.276106182923122 3474 2203047
SGTC_1588 farnesol 29.9 µM -0.594588641943271 0.320091935442566 no 2278 0.276059237062925 3537 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2946 9065502 71.43 µM -0.596080309996133 0.319629655389937 no 2279 0.275560788645167 3376 16489101
SGTC_2155 5570423 76 µM -0.596434545941372 0.319519915922053 no 2280 0.275442483979876 3427 797402
SGTC_3263 9137018 49.47 µM -0.596450531358342 0.319514964140086 no 2281 0.275437145897499 3469 43844957
SGTC_1040 k898-0338 155 µM -0.596938841993442 0.319363716295384 no 2282 0.275274106652854 3569 20969351
SGTC_859 0439-0102 54.6 µM -0.597308545590286 0.319249225420057 no 2283 0.275150700039202 3552 610143
SGTC_1691 st019933 84.6 µM -0.597547239925169 0.319175315025792 no 2284 0.275071038633681 3498 6176082
SGTC_1135 dihydrocapsaicin 536.708 nM -0.599691414646416 0.318511705592229 no 2285 0.274355955500321 3493 107982 A Capsaicinoid.
SGTC_2695 st077686 51.995 µM -0.600726944380025 0.318191423440681 no 2286 0.274010934838939 3484 2876092
SGTC_1867 st057372 64 µM -0.601048874097712 0.318091880493715 no 2287 0.273903717114169 3522 688837
SGTC_2346 9031566 143.75 µM -0.601617233657169 0.317916171772895 no 2288 0.27371447731623 3441 4771086
SGTC_1836 st055642 81 µM -0.601697756484801 0.317891281403104 no 2289 0.273687671837061 3438 8571
SGTC_1062 mesoridazine 14.2 µM -0.602089053093326 0.317770339624774 no 2290 0.273557430458191 3524 4078 A neuroleptic.
SGTC_3002 9075603 71.4286 µM -0.602365509976726 0.317684904174588 no 2291 0.273465431478453 3503 20105405
SGTC_262 fenpropimorph 62.5 µM -0.60288117908118 0.317525569201726 no 2292 0.273293868691996 3493 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_682 0kpi-0099 17 µM -0.604140903394225 0.317136473134062 no 2293 0.272874983526997 3538 1714895 YML126C ERG13
SGTC_1837 st055472 66.5 µM -0.604836160993172 0.316921812659256 no 2294 0.272643932014358 3595 676091
SGTC_1090 efavirenz 20.7 µM -0.608190504478628 0.315887027316701 no 2295 0.271530565826552 3543 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_280 3448-3607 3.04 µM -0.610698565988042 0.315114253512324 no 2296 0.270699577781926 3533 626179
SGTC_196 k015-0023 18.111 µM -0.611452717115325 0.31488204544496 no 2297 0.270449955846716 3522 5211998
SGTC_1394 3474-0001 65.7 µM -0.611894275571409 0.314746120659336 no 2298 0.270303854630497 3451 5017666 YIL048W NEO1
SGTC_2635 hydroquinidine 100 µM -0.61384419618163 0.314146177588157 no 2299 0.269659144403256 3525 442912 An experimental heart treatment.
SGTC_2284 7945075 39.21 µM -0.61512414419389 0.313752635447163 no 2300 0.269236369130721 3561 1245402
SGTC_346 4513-0042 7.16 µM -0.61551439449031 0.313632688363755 no 2301 0.2691075330531 3553 2827372
SGTC_455 paf C-16 10 µM -0.616018313003897 0.313477833432964 no 2302 0.268941216663688 3522 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3045 9092950 49.47 µM -0.617044682500748 0.313162530191571 no 2303 0.268602626983954 3586 44120432
SGTC_152 4469-0003 551.229 µM -0.617558079278243 0.313004864656724 no 2304 0.268433342615538 3562 697280
SGTC_1899 st063254 59.6 µM -0.617600059912175 0.312991973802634 no 2305 0.268419502546642 3492 3093813
SGTC_1244 0416-0015 52.5 µM -0.619315498919046 0.312465415316743 no 2306 0.267854268048417 3547 96201
SGTC_53 0973-0023 39.979 µM -0.619596700521658 0.312379136227006 no 2307 0.267761669784421 3561 674768
SGTC_1925 st057770 10.1 µM -0.619845569551823 0.312302786089908 no 2308 0.267679731929149 3436 5989122
SGTC_3230 9131665 49.47 µM -0.620398035915147 0.312133324611241 no 2309 0.26749788259961 3486 15943720
SGTC_463 ikarugamyin 104 µM -0.620711565955726 0.31203717124723 no 2310 0.267394709050565 3571 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.621185103372559 0.311891971112826 no 2311 0.267238919825042 3613 94937 An inhibitor of serotonin biosynthesis.
SGTC_223 busulfan 5 mM -0.623493438183464 0.311184588405383 no 2312 0.266480156480859 3529 2478 A DNA alkylator.
SGTC_2236 dapsone 200 µM -0.624171902933188 0.310976807175433 no 2313 0.266257348488595 3572 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2188 6126565 140.678 µM -0.624502106426543 0.310875703464733 no 2314 0.266148943703902 3519 874518
SGTC_2921 7974240 10.71 µM -0.624588410957185 0.310849280572398 no 2315 0.2661206138779 3559 2979074 YDR527W RBA50
SGTC_1446 4239-0190 62 µM -0.625084975162551 0.310697272019371 no 2316 0.265957644257569 3527 1340085
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.625403930472692 0.310599650255073 no 2317 0.26585299156784 3477 641818 YHR062C RPP1
SGTC_303 1348-1668 34.2 µM -0.626475603371861 0.310271744022047 no 2318 0.265501517017548 3549 5380509
SGTC_558 k064-0027 21.3 µM -0.62736217953425 0.310000586897886 no 2319 0.265210926583084 3545 5088526
SGTC_827 3253-0474 693 µM -0.627561150959805 0.309939746168995 no 2320 0.265145732506207 3574 5402065
SGTC_2602 kawain 100 µM -0.628437391793109 0.309671874510398 no 2321 0.264858724278875 3561 5369129
SGTC_1807 st050092 58.9 µM -0.631445763793281 0.308752968322689 no 2322 0.263874550593191 3503 5008496
SGTC_2176 5809774 33.9695 µM -0.631998549244361 0.308584250110152 no 2323 0.26369391260357 3547 2870539
SGTC_2043 5101342 149 µM -0.632163839569283 0.308533808928672 no 2324 0.263639911654561 3519 678451
SGTC_2159 5658611 73.75 µM -0.632170457201184 0.308531789519863 no 2325 0.263637749767668 3588 793844
SGTC_36 0335-0881 14.2 µM -0.632220803572856 0.308516426221786 no 2326 0.26362130261514 3515 23828853
SGTC_996 3970-0799 1.8 µM -0.632524027189564 0.308423904006974 no 2327 0.263522256597094 3628 6615648 YGL040C HEM2
SGTC_2072 5231554 129 µM -0.633418820771551 0.308150947780428 no 2328 0.26323008885632 3641 789545
SGTC_1674 st016616 23.6 µM -0.633618628225401 0.308090011122328 no 2329 0.263164870390253 3555 625830
SGTC_1007 4101-0031 70 µM -0.633713560709899 0.308061060761033 no 2330 0.263133886696554 3561 1146276
SGTC_2321 7390090 138.78 µM -0.63518806821767 0.307611552246625 no 2331 0.262652882105599 3497 649046
SGTC_863 0466-0191 129 µM -0.635498268645947 0.307517023348815 no 2332 0.26255174777643 3569 765160 YPR165W RHO1
SGTC_1232 0279-0259 161 µM -0.635524045648794 0.30750916877141 no 2333 0.262543344623508 3585 1560000
SGTC_3231 9132313 49.47 µM -0.635730503057797 0.307446261783328 no 2334 0.262476045676579 3548 4905967
SGTC_1168 k815-0004 80.5 µM -0.637170967591264 0.307007513999443 no 2335 0.262006743162745 3548 642433
SGTC_1218 1348-1416 30.7 µM -0.638172697838686 0.306702562074624 no 2336 0.261680633801153 3573 6787668
SGTC_590 k048-0076 22.4 µM -0.63847964321297 0.306609146930441 no 2337 0.261580750640211 3587 6832814
SGTC_1073 triclabendazole 3.09 µM -0.63949729439923 0.306299526886074 no 2338 0.26124973659673 3608 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_860 0443-0016 25.1 µM -0.639502112573598 0.306298061286793 no 2339 0.261248169888693 3591 5337942
SGTC_1637 st007924 17.4 µM -0.640565268546729 0.305974744785083 no 2340 0.260902585462355 3585 683336
SGTC_139 0099-0334 718.624 µM -0.641842080050947 0.305586653198151 no 2341 0.260487862147088 3620 97690
SGTC_848 0368-0089 85.6 µM -0.641866424716122 0.305579255666638 no 2342 0.260479958014285 3570 762535
SGTC_2755 lomerizine 42.69 µM -0.642081129511719 0.305514017479328 no 2343 0.260410253830518 3577 3949 A calcium channel blocker.
SGTC_321 4534-3890 65.3 µM -0.643082907882156 0.30520970813296 no 2344 0.260085152250674 3585 699746
SGTC_2004 4023728 41.89 µM -0.643927911105669 0.304953126874344 no 2345 0.259811090818712 3571 360084 YDR527W RBA50
SGTC_1134 3477-0009 42.5 µM -0.645061606367215 0.304609036237156 no 2346 0.259443631576174 3648 3973534
SGTC_1993 st073995 70.8 µM -0.645285553479155 0.304541085929278 no 2347 0.259371076430114 3589 3098394
SGTC_2788 5282734 71.43 µM -0.646910576232183 0.304048221684431 no 2348 0.258844910223743 3620 743706
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.649613405525077 0.303229250649377 no 2349 0.257970985821595 3599 16486 A toxic proline analog.
SGTC_405 ebelactone b 50 µM -0.649801753461722 0.303172217041854 no 2350 0.257910143083228 3577 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_500 h-89 112 µM -0.650511517044088 0.302957336763026 no 2351 0.257680932407609 3635 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1255 0566-0045 221 µM -0.653315910316823 0.302108976819256 no 2352 0.25677631868582 3621 2788469
SGTC_165 k038-0023 64.381 µM -0.654578876033791 0.301727264387549 no 2353 0.256369464111601 3589 46368543
SGTC_2492 derrusnin 100 µM -0.655900800546927 0.301327964971527 no 2354 0.255943976547649 3544 1715307 Part of coumarin class of compounds.
SGTC_1826 st055655 41.6 µM -0.656936396459755 0.301015320044695 no 2355 0.255610907088476 3604 676168
SGTC_492 tmb-8 126 µM -0.657461431987189 0.300856868450692 no 2356 0.25544213112333 3512 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_885 0865-0106 16.8 µM -0.657652810812341 0.300799121183212 no 2357 0.255380625683496 3574 2793380
SGTC_382 3229-0966 23.2 µM -0.65832909513284 0.300595097027982 no 2358 0.255163343044703 3632 5722370
SGTC_924 2046-0044 21.3 µM -0.658780214954077 0.300459036146586 no 2359 0.255018457029912 3628 3623589
SGTC_713 1488-1073 324 µM -0.659953786448849 0.30010520919623 no 2360 0.254641743153279 3590 3312542
SGTC_2545 solidagenone 89.61 µM -0.660736677514188 0.299869275625626 no 2361 0.2543905989972 3467 6708572 An anti ulcer agent
SGTC_1280 0880-0253 10.1 µM -0.662860521552414 0.299229653134512 no 2362 0.253709943963523 3591 6836607
SGTC_1182 1222-0449 220 µM -0.664859370132704 0.298628240710466 no 2363 0.253070222451785 3600 658318
SGTC_3200 9114385 49.47 µM -0.665150748669593 0.298540616825011 no 2364 0.252977039122422 3608 17018030 YLR208W SEC13
SGTC_2126 5251174 33.877 µM -0.666480345381203 0.298140926603683 no 2365 0.252552061206371 3651 790722
SGTC_1951 sophoraflavanone G 9.2 µM -0.667604238611811 0.2978032631651 no 2366 0.252193125686021 3634 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_597 k018-0003 82.8 µM -0.668244899537925 0.297610860537087 no 2367 0.251988639549138 3691 6786234
SGTC_1336 1486-0901 104 µM -0.668416620251336 0.297559299192875 no 2368 0.251933844608715 3624 5006114
SGTC_1924 st058459 75.1 µM -0.668963612766149 0.297395084872207 no 2369 0.251759344852917 3596 688683
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.670151542302113 0.297038595505552 no 2370 0.251380595387818 3641 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2288 7946289 167.31 µM -0.670193206331345 0.297026095969274 no 2371 0.251367317048176 3658 1246052
SGTC_1673 st016611 27.3 µM -0.670996102742486 0.296785267737404 no 2372 0.251111506132744 3640 5226799
SGTC_1705 st027868 56.3335 µM -0.671852999343904 0.296528340836334 no 2373 0.250838642202845 3640 292948
SGTC_2387 9077560 195.08 µM -0.672122252735063 0.296447630510582 no 2374 0.250752935529507 3622 5303272
SGTC_1437 4092-1038 11.6 µM -0.67253084612738 0.296325171416625 no 2375 0.250622904842151 3629 3977136
SGTC_2285 7945142 200 µM -0.672798102184688 0.296245084935833 no 2376 0.250537872648575 3637 2970608
SGTC_2879 9041815 71.43 µM -0.673025544933548 0.296176936810406 no 2377 0.250465519797585 3586 4942971
SGTC_975 1335-0046 28.5 µM -0.674490759476595 0.295738090598141 no 2378 0.249999679274407 3612 16486740
SGTC_861 0443-0273 110 µM -0.674577309307857 0.295712177417906 no 2379 0.24997217658719 3644 6149169
SGTC_364 0083-0097 67.7 µM -0.675767738974122 0.29535586648501 no 2380 0.249594060199937 3664 5207356
SGTC_1825 st052143 62.6 µM -0.676336514761113 0.295185694333513 no 2381 0.249413507169987 3650 674173
SGTC_674 0498-0004 451 µM -0.677690861822759 0.29478066876518 no 2382 0.248983860831267 3610 4231473
SGTC_818 4072-2707 53.5 µM -0.678855709286297 0.294432519276884 no 2383 0.248614645681376 3593 882871
SGTC_2970 9090938 41.86 µM -0.679376840047092 0.294276825247991 no 2384 0.248449560268441 3646 17217104
SGTC_1169 aniline yellow 25.8 µM -0.681458464447766 0.29365529478218 no 2385 0.247790720007579 3612 6051 A DNA damaging agent.
SGTC_1363 1636-0063 10.4 µM -0.681908376171782 0.293521040245736 no 2386 0.24764844430905 3679 6072185
SGTC_528 3492-0019 172 µM -0.683475391963681 0.293053661737369 no 2387 0.247153247326489 3675 2869262
SGTC_3020 9089140 49.47 µM -0.683728159035885 0.29297830371531 no 2388 0.247073419338226 3654 17217859
SGTC_970 1315-0089 19.5 µM -0.683790071328175 0.292959847033789 no 2389 0.247053868523766 3603 6811083 YLR033W RSC58
SGTC_209 4077-0173 175.592 µM -0.68409953716351 0.29286760022267 no 2390 0.246956157057276 3587 15993494
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.68485364084124 0.292642870465278 no 2391 0.246718141219692 3617 6857784
SGTC_1888 azatryptophan 97.5 µM -0.685028933450849 0.292590643149779 no 2392 0.246662831657126 3617 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2340 7987427 183.45 µM -0.686186054160607 0.29224599510948 no 2393 0.246297895410643 3619 2239331
SGTC_3098 9119039 49.47 µM -0.686487668083793 0.292156190535256 no 2394 0.246202819073215 3673 17161528
SGTC_3087 9117406 49.47 µM -0.686533844420741 0.292142442813216 no 2395 0.246188264861202 3642 42546093
SGTC_3297 9117502 71.43 µM -0.6876574826816 0.291808003554124 no 2396 0.245834250188613 3640 7453720
SGTC_1278 0874-0585 172 µM -0.687843868912919 0.29175254488075 no 2397 0.245775553576892 3680 766306
SGTC_1879 gemcitabine 100 µM -0.688003495764659 0.291705052286635 no 2398 0.245725289990582 3663 60750 A nucleoside analog which inhibits DNA replication.
SGTC_919 tnp00227 403.569 nM -0.688448757746907 0.291572595835736 no 2399 0.245585114282311 3671 1269246 A methoxyflavone. YNL221C POP1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.689095692082322 0.291380195921538 no 2400 0.245381525402122 3652 616764
SGTC_2766 oltipraz 83.91 µM -0.690777467585969 0.290880308981292 no 2401 0.24485269883658 3644 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1738 st035555 74 µM -0.690883428259279 0.29084882691122 no 2402 0.24481940054368 3675 5331140
SGTC_2024 5144227 134 µM -0.690898502899048 0.290844348200985 no 2403 0.244814663514661 3672 3475211
SGTC_1811 st050069 61.5 µM -0.692671297990201 0.290317871668038 no 2404 0.244257927630486 3642 3877702
SGTC_453 enantio-paf c16 10 µM -0.694803623466339 0.289685215357069 no 2405 0.243589188548349 3654 13871343 A lipid and platelet activating factor
SGTC_2481 5478948 45.16 µM -0.694991955063285 0.289629368896562 no 2406 0.243530171626136 3673 77792
SGTC_1436 4092-1007 8.32 µM -0.695494310116033 0.289480428965535 no 2407 0.243372787874525 3642 2881121
SGTC_2319 6033012 152.6 µM -0.699577186176139 0.288271260371928 no 2408 0.242095697038388 3649 847246
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.699652570971033 0.288248957119956 no 2409 0.242072151494745 3690 6708739 YPR165W RHO1
SGTC_1220 1838-0075 193 µM -0.703807909850794 0.287020824453873 no 2410 0.240776203563056 3637 5529645
SGTC_604 1000-0114 314 µM -0.705512719274253 0.286517676857664 no 2411 0.240245609668615 3713 1572745
SGTC_2757 clomiphene 4.22 µM -0.708899026860054 0.285519504599257 no 2412 0.239193569523271 3736 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1880 MG-132 525 µM -0.708992415788643 0.285492000082156 no 2413 0.239164591658658 3632 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_208 k072-0098 12.366 µM -0.709283978162891 0.285406138467118 no 2414 0.239074134447541 3697 5948901
SGTC_963 1269-2853 151 µM -0.709402316247942 0.28537129283212 no 2415 0.239037425399268 3684 3668223
SGTC_1775 st081588 35.1725 µM -0.709660979991271 0.285295134193607 no 2416 0.238957197380467 3724 1426443 YGL099W LSG1
SGTC_2793 7325131 81.82 µM -0.713634374472148 0.284126461952386 no 2417 0.237726648029846 3686 4176441
SGTC_3249 9135183 49.47 µM -0.715034931799706 0.283715070315354 no 2418 0.237293729327519 3707 4902779
SGTC_684 1140-0066 328 µM -0.716985261754386 0.28314266729803 no 2419 0.236691595331683 3715 6813534
SGTC_3340 9146634 11.102 µM -0.717211315132212 0.283076358664745 no 2420 0.236621859264676 3712 4907387
SGTC_1256 0570-0116 285 µM -0.720239951458069 0.282188683044653 no 2421 0.235688634801796 3718 410638
SGTC_1574 spiramycin 23.7 µM -0.720609549910232 0.282080447694973 no 2422 0.23557488825435 3710 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1988 st071872 53.4 µM -0.72072639554618 0.282046234101912 no 2423 0.235538934481857 3709 16414116
SGTC_2074 5212007 75.395 µM -0.721533539269465 0.281809948790489 no 2424 0.235290656506459 3619 758611
SGTC_560 2332-1943 155 µM -0.721651969332178 0.281775287299377 no 2425 0.235254239495 3698 21177716
SGTC_2186 6124449 200 µM -0.722222572709686 0.281608314894972 no 2426 0.235078823703606 3667 3834182 YLR033W RSC58
SGTC_2521 angolensin 13.4 µM -0.725182337724622 0.280742982296362 no 2427 0.234170088425611 3738 821428 A flavenoid.
SGTC_3024 9090631 49.47 µM -0.729253271875255 0.279554887281981 no 2428 0.232923375076581 3656 25236383
SGTC_2657 nystatin 74.44 µM -0.729488894562062 0.279486196015922 no 2429 0.232851329270084 3743 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_543 3844-1095 191 µM -0.729601560596169 0.279453353295822 no 2430 0.232816884012079 3731 4230703
SGTC_1989 st071868 50.2 µM -0.731036270453325 0.279035292086831 no 2431 0.232378499465595 3702 16414057
SGTC_1089 terbinafine 2.25 µM -0.731094255632876 0.279018402137596 no 2432 0.232360791391304 3713 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_526 4469-0568 170 µM -0.73176306026823 0.278823628371229 no 2433 0.232156599639967 3721 2901964
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.733445434705776 0.278333968788283 no 2434 0.231643398245123 3761 1377
SGTC_3188 9110789 49.47 µM -0.734757039039116 0.277952513830887 no 2435 0.231243737731989 3734 849217
SGTC_2638 epoxomicin 18 µM -0.7379041587993 0.277038276292793 no 2436 0.230286345796 3747 9915668 A protesome inhibitor.
SGTC_2363 9053361 176 µM -0.739931180697808 0.276450207254256 no 2437 0.22967087673523 3763 6469797 YMR079W SEC14
SGTC_2061 5245884 80.95 µM -0.740026682884738 0.276422515764047 no 2438 0.229641901943424 3719 573863
SGTC_868 0527-0199 213 µM -0.743021622699832 0.275554804082461 no 2439 0.228734294749496 3703 2849450
SGTC_3146 9095609 49.47 µM -0.743641688854413 0.275375322367153 no 2440 0.228546637593873 3812 17173999
SGTC_2324 6149169 200 µM -0.744819415403419 0.275034581114831 no 2441 0.228190448023795 3687 2888231
SGTC_978 1416-0512 87.4 µM -0.744883241996042 0.275016120663336 no 2442 0.228171153339525 3810 6814003
SGTC_993 3909-8757 62.7 µM -0.745033073086734 0.274972787682766 no 2443 0.22812586322729 3725 4288324 YLR208W SEC13
SGTC_1886 st057356 49.9 µM -0.745616875039809 0.274803977127554 no 2444 0.227949443034986 3732 24207747
SGTC_1117 retinoic acid 1.10837 µM -0.747604238163271 0.274229699969317 no 2445 0.227349453803335 3753 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2076 5212012 200 µM -0.747696466142997 0.274203063765356 no 2446 0.227321631596902 3660 604802
SGTC_1616 st002734 56.1 µM -0.748393728523649 0.274001729975762 no 2447 0.227111352116114 3729 4026101
SGTC_415 dibenzyl ketone 100 µM -0.748417398721547 0.273994896513036 no 2448 0.227104215613637 3777 7593
SGTC_1995 st072814 61.1 µM -0.748462920422284 0.27398175487212 no 2449 0.227090491295826 3730 5769371
SGTC_1019 4262-0212 3.4 µM -0.749780383789716 0.273601551950765 no 2450 0.226693492484852 3787 4677213
SGTC_1934 st074720 32.6 µM -0.750820166848794 0.273301668430341 no 2451 0.226380445412895 3719 17250992
SGTC_2848 9016370 25.97 µM -0.752054634543755 0.272945847478026 no 2452 0.226009101918379 3744 7894410
SGTC_523 1934-0222 13.7 µM -0.752947647535556 0.272688590138669 no 2453 0.225740687104192 3749 1361595
SGTC_2693 st077581 40.7 µM -0.752947845068496 0.272688533247101 no 2454 0.225740627751251 3817 25238761
SGTC_217 ketoconazole 989 nM -0.753136038633052 0.272634334193805 no 2455 0.225684085033723 3668 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2642 cholecalciferol 100 µM -0.754367204543089 0.272279894906988 no 2456 0.225314379224289 3734 9821465 A vitamin D precursor, similar to steriods.
SGTC_2703 st077852 53.4 µM -0.754782552216173 0.272160372496772 no 2457 0.225189732220071 3749 6281836
SGTC_2130 NSC 7 2.4545 µM -0.755292266001834 0.272013730497271 no 2458 0.225036819074965 3795 21448
SGTC_615 k087-0205 167 µM -0.756518130085828 0.27166121675152 no 2459 0.224669303258858 3768 9642773
SGTC_909 3448-9333 149 µM -0.7572025470174 0.271464502420073 no 2460 0.22446426226003 3711 3344074
SGTC_264 promethazine 12.5 mM -0.757250250379632 0.271450794219966 no 2461 0.224449975011335 3764 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_792 4534-1957 155 µM -0.757282606602623 0.27144149642217 no 2462 0.224440284554093 3745 1717904
SGTC_489 paxilline 115 µM -0.759714625260092 0.270743092509051 no 2463 0.223712592321296 3725 105008 A toxic potassium channel blocker.
SGTC_521 r062-0005 13.8 µM -0.762039692572709 0.270076241762806 no 2464 0.223018157286272 3697 2832033
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.762085219560134 0.27006319241018 no 2465 0.223004571866343 3833 688788
SGTC_42 0133-0086 60.653 µM -0.762556995647048 0.269927986299876 no 2466 0.2228638199041 3693 162923 Model of phenazepam hydroxylation.
SGTC_2941 9056145 11.23 µM -0.765015497535394 0.269223954050319 no 2467 0.222131158179053 3649 2119517
SGTC_291 SEC14.278 35.5 µM -0.76522062238382 0.269165254851577 no 2468 0.222070090822931 3756 1068044
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.766413403361805 0.268824052012698 no 2469 0.221715180051558 3803 2374 Ca(2+)-ATPase inhibitor.
SGTC_341 1486-1430 230 µM -0.768803678848399 0.26814095245575 no 2470 0.221004932312477 3749 2054753 YPL210C SRP72
SGTC_2670 beta-carotene 100 µM -0.768878190831235 0.268119672263675 no 2471 0.220982812731549 3701 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_662 k832-1615 104 µM -0.769855719993414 0.267840574326104 no 2472 0.220692741412833 3832 5878478
SGTC_2300 7976697 71.57 µM -0.771178174724923 0.267463228487086 no 2473 0.220300664436869 3717 2236109
SGTC_1845 st056753 3.01 µM -0.772127238739285 0.26719259033973 no 2474 0.220019535404859 3758 5375839
SGTC_1137 ixabepilone 100 µM -0.772301597160504 0.267142884765056 no 2475 0.21996790984039 3781 154225 A novel microtubule stabilizer.
SGTC_162 k030-0015 37.8 µM -0.772607637193994 0.267055651080585 no 2476 0.219877311642753 3852 1809920 YMR134W ERG29
SGTC_931 2812-0076 566 µM -0.773756605227992 0.266728277526139 no 2477 0.21953736944208 3810 3450959
SGTC_2730 imipramine 71.33 µM -0.77412683757766 0.266622831065996 no 2478 0.219427894098506 3789 3696 A tricyclic antidepressant.
SGTC_2827 7993847 71.43 µM -0.775233077681528 0.266307886701332 no 2479 0.219100972893474 3838 2985692
SGTC_1694 st024011 44.9 µM -0.776040356145497 0.266078175012075 no 2480 0.218862579084187 3829 2787533
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.776719706715068 0.265884943086508 no 2481 0.218662078776844 3820 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1001 4048-4355 44.4 µM -0.77717689604509 0.265754941912529 no 2482 0.218527205624316 3794 21824233
SGTC_320 4092-0846 5.34 µM -0.778564839665695 0.265360479494072 no 2483 0.218118048842322 3782 1359356
SGTC_3295 9122362 53.5725 µM -0.77863976680961 0.265339193179721 no 2484 0.218095973374904 3838 4730473
SGTC_1917 st066507 28.5 µM -0.778764455283168 0.265303771916519 no 2485 0.218059239792347 3770 3156428
SGTC_2862 9027634 71.43 µM -0.779323071132574 0.265145110865036 no 2486 0.217894713745735 3738 5012562
SGTC_640 3381-0960 37.1 µM -0.779838972043713 0.264998624752845 no 2487 0.217742831899344 3836 1745025
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.78347437728751 0.263967546414637 no 2488 0.216674297207901 3849 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_904 1141-0088 396 µM -0.783727802788559 0.263895745856463 no 2489 0.216599922493046 3816 1378119
SGTC_2455 5377712 9.75 µM -0.783932434001207 0.263837776970786 no 2490 0.216539878588609 3806 2243908
SGTC_2649 anisomycin 9.56 µM -0.784708294911921 0.263618046458406 no 2491 0.216312309129754 3801 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2268 7933382 153.85 µM -0.786226411990419 0.263188372823614 no 2492 0.215867427596136 3843 935025 YOR257W CDC31
SGTC_2569 tetrandrine 100 µM -0.788356666313965 0.262586049414898 no 2493 0.215244055214595 3836 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_178 4092-0806 87.505 µM -0.788403909257472 0.262572699606015 no 2494 0.2152302424515 3769 2169044
SGTC_1494 4358-1428 177 µM -0.788423294813607 0.262567221777965 no 2495 0.215224574704283 3833 1564571
SGTC_760 0568-0725 82.9 µM -0.790958492357049 0.261851348601946 no 2496 0.214484106753925 3860 3916171
SGTC_2366 9070441 60.58 µM -0.791633338858274 0.261660958519407 no 2497 0.214287250830875 3814 6837235
SGTC_2772 vinpocetine 57.06 µM -0.791834541662166 0.261604208222947 no 2498 0.214228579364041 3810 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_547 1120-0019 610 nM -0.792030884895984 0.261548834684389 no 2499 0.214171333976304 3740 3676939
SGTC_83 0170-0301 39.027 µM -0.792971736654865 0.26128357526319 no 2500 0.213897144912934 3749 3089716
SGTC_3343 9148379 18.9835 µM -0.794625307854661 0.260817710134837 no 2501 0.213415746143446 3872 1955036
SGTC_1937 st074714 47.2 µM -0.795220851318218 0.26065003077455 no 2502 0.213242522329097 3789 17250970
SGTC_1044 1222-0021 1.78 µM -0.795389156397359 0.260602653379342 no 2503 0.213193582834958 3827 4306703
SGTC_273 hydroxyurea 18.1 mM -0.795762836369996 0.260497479392746 no 2504 0.213084948162445 3884 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.795833601773677 0.260477564598672 no 2505 0.213064379178722 3847 229346 A bile salt which induces apoptosis.
SGTC_2971 9092186 9.93 µM -0.796209055168856 0.26037191765128 no 2506 0.212955267619665 3852 25236400
SGTC_2859 9028643 45.46 µM -0.796234999279039 0.260364618183664 no 2507 0.212947729133979 3745 17151580
SGTC_2625 euphol 100 µM -0.798337702163196 0.259773365944758 no 2508 0.21233727233911 3831 6708538 A triterpene alcohol.
SGTC_2407 paclitaxel 400 µM -0.800435122489334 0.259184290084592 no 2509 0.211729369214355 4009 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2329 6138490 200 µM -0.801676384412032 0.258835998106951 no 2510 0.211370089905733 3952 720019
SGTC_265 mycophenolic acid 32.932 µM -0.80185506505442 0.258785881147002 no 2511 0.211318400780316 3896 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1339 1486-1321 22.7 µM -0.802795915186511 0.258522071136195 no 2512 0.211046351774096 3857 3469382
SGTC_1248 0469-0687 58.6 µM -0.804045924169075 0.258171789995895 no 2513 0.210685226516194 3841 4017482
SGTC_111 0083-0039 52.457 µM -0.808564710785006 0.256907578086489 no 2514 0.209382785059671 3739 759313
SGTC_2744 captopril 92.04 µM -0.810301268061356 0.256422603146831 no 2515 0.208883523364893 3805 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1295 1013-0063 9.78 µM -0.812229551979523 0.255884643463779 no 2516 0.208329962695907 3826 6826038
SGTC_1767 st044992 70.3 µM -0.812327499553345 0.255857333419609 no 2517 0.208301867583107 3899 9600693
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.812437208972307 0.25582674570788 no 2518 0.208270401377044 3839 6708760
SGTC_2867 9039098 71.43 µM -0.812621425013411 0.255775389350557 no 2519 0.208217571930967 3798 6463460
SGTC_2993 9054257 71.4286 µM -0.813043693687888 0.255657688203798 no 2520 0.208096503629615 3811 6470217 YGL055W OLE1
SGTC_2118 5526350 200 µM -0.813244487359961 0.255601729862073 no 2521 0.208038948821179 3908 743594
SGTC_2959 9079155 11 µM -0.813980785596356 0.255396588763229 no 2522 0.207827979242293 3867 16189457
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.816272465787489 0.254758651569965 no 2523 0.207172159334242 3899 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1315 1237-0019 3.69 µM -0.816701535225512 0.254639303892451 no 2524 0.207049506887527 3866 825140
SGTC_2056 5235370 200 µM -0.817790167363132 0.254336627205352 no 2525 0.206738506758454 3842 5511916
SGTC_2011 4012611 177 µM -0.818016274293514 0.254273785464712 no 2526 0.206673947298595 3881 2049887
SGTC_2567 aureobasidin a 60 nM -0.819867643718925 0.253759542029451 no 2527 0.206145781985419 4027 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1324 1418-0026 34.4 µM -0.821038224978366 0.25343467891539 no 2528 0.205812247706059 3917 1372513
SGTC_945 3381-0768 11.3 µM -0.821667602533575 0.253260102617714 no 2529 0.205633051293643 3920 1126236 YIL048W NEO1
SGTC_3025 9087895 49.47 µM -0.822135100387318 0.253130469334418 no 2530 0.205500005244046 3885 17173641
SGTC_1003 4049-0218 100 µM -0.823651668849591 0.252710177831841 no 2531 0.205068754305077 3877 295161
SGTC_481 bay k-8644 50 µM -0.824797055454355 0.252392996905114 no 2532 0.204743409338585 3845 2303 A calcium channel antagonist.
SGTC_373 0844-0104 25.9 µM -0.824865461106127 0.252374060626359 no 2533 0.204723988558837 3916 5375804
SGTC_2215 7188065 200 µM -0.826723623053666 0.251859964686731 no 2534 0.204196864363243 3874 940217
SGTC_3155 9099265 49.47 µM -0.826929891976517 0.251802930563657 no 2535 0.204138399789666 3895 25236499
SGTC_2238 6671620 73.2395 µM -0.828198001802104 0.251452443365563 no 2536 0.203779187644678 3822 729941
SGTC_2246 7293507 91.5585 µM -0.831106446437899 0.250649566140687 no 2537 0.202956749168942 3928 887656
SGTC_1383 3049-0032 20.7 µM -0.831543066615502 0.250529154306989 no 2538 0.202833454805211 3954 712864
SGTC_510 ag-490 170 µM -0.831555215209646 0.250525804385949 no 2539 0.20283002488179 3998 5328779
SGTC_2898 9056270 58.44 µM -0.834396689846563 0.249742932740453 no 2540 0.202028740970914 3833 19154699
SGTC_2676 harmalol 100 µM -0.835386015952886 0.24947066280417 no 2541 0.201750200412746 3837 5459187 A monoamine oxidase inhibitor
SGTC_2099 5377090 177.372 µM -0.836525546840463 0.249157250977053 no 2542 0.201429655509318 3920 2243829
SGTC_3245 9134821 49.47 µM -0.836670868466295 0.249117297384528 no 2543 0.201388799146029 3883 17014901
SGTC_3028 9087778 49.47 µM -0.83742813975126 0.248909154296026 no 2544 0.201175976944774 3869 17217395
SGTC_2747 doxorubicin 7.63 µM -0.838697954288826 0.248560341746519 no 2545 0.200819413301373 3776 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1842 st055362 61.2 µM -0.838732834669671 0.248550763933423 no 2546 0.200809624253194 3857 676032
SGTC_2570 licareol 100 µM -0.839660951425889 0.248295984344901 no 2547 0.200549256964421 3913 443158
SGTC_1660 st012960 28.1 µM -0.840056054989849 0.248187565773749 no 2548 0.200438478960953 3896 24207266
SGTC_2828 7998861 71.43 µM -0.840129747070795 0.24816734705913 no 2549 0.200417821454352 3802 2988188
SGTC_1404 3909-7820 48.3 µM -0.840216107183552 0.248143653765869 no 2550 0.200393614448138 3833 23741373
SGTC_3166 9102297 49.47 µM -0.842408249571235 0.247542633670051 no 2551 0.19977973846776 3915 25237072
SGTC_844 0330-0132 15.3 µM -0.842409534572404 0.247542281589259 no 2552 0.199779378954881 3921 2828079
SGTC_2279 7948423 32.93 µM -0.843783681437285 0.247165928702047 no 2553 0.199395147985528 3825 1247112
SGTC_893 0958-0369 48.9 µM -0.846809055968048 0.246338415418207 no 2554 0.19855077986854 3883 6819948
SGTC_1326 1431-2094 10.8 µM -0.847514286696853 0.246145731375471 no 2555 0.198354263635963 3886 616278
SGTC_2239 6685329 187.64 µM -0.848045283263156 0.246000705173637 no 2556 0.198206376152712 3974 805680
SGTC_2270 7924575 90.91 µM -0.848516819211002 0.245871957344666 no 2557 0.1980751048186 3918 1262135
SGTC_1084 voriconazole 435 nM -0.849442396187571 0.245619343687547 no 2558 0.197817585286204 3891 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2167 5876490 200 µM -0.849539623027238 0.245592816086203 no 2559 0.197790546001959 4062 686534
SGTC_232 clozapine 119 µM -0.850324068008298 0.245378842565536 no 2560 0.197572469522191 3856 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3264 9137442 49.47 µM -0.850493873256103 0.245332537882744 no 2561 0.197525282639872 3865 17015726
SGTC_3248 9135562 49.47 µM -0.850996558018465 0.245195486861848 no 2562 0.197385632399789 3908 17650701
SGTC_328 k915-0120 63.5 µM -0.853113870919654 0.244618678837279 no 2563 0.196798079998554 3896 6624543
SGTC_3064 1327-0027 10 µM -0.853127650171773 0.244614927425496 no 2564 0.196794259740622 3783 16000455 YPR107C YTH1
SGTC_1780 st038448 24.544 µM -0.853776901065247 0.244438203508407 no 2565 0.196614307714225 3971 728868 YDL195W SEC31
SGTC_1246 0422-0085 105 µM -0.854531271664486 0.244232952793056 no 2566 0.196405345045611 3945 264295
SGTC_3032 9089427 49.47 µM -0.854892042636649 0.244134826332556 no 2567 0.196305458121455 3918 17173707
SGTC_2753 fluvastatin 17.09 µM -0.855221445411143 0.24404525031074 no 2568 0.196214283034682 3969 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1548 st061468 90.8 µM -0.855430357494232 0.243988449068851 no 2569 0.196156471762573 3893 390799
SGTC_2301 7769476 200 µM -0.856030110480694 0.243825421475259 no 2570 0.195990562301006 3952 977820
SGTC_1098 clofazimine 15.1 µM -0.857225405429715 0.243500686367893 no 2571 0.195660162266437 3987 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_980 1473-0395 201 µM -0.86265450492627 0.242028665466272 no 2572 0.194163726589237 3814 768876
SGTC_3304 9125678 46.087 µM -0.863621125256042 0.241767087551881 no 2573 0.193898027664889 3868 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_738 1315-0003 72.4 µM -0.863914592128564 0.241687702614757 no 2574 0.193817405083896 3951 6251474
SGTC_1342 1486-1464 234 µM -0.86549383555918 0.24126074875641 no 2575 0.193383898960407 3939 3253938
SGTC_113 0099-0221 2.5 µM -0.865900351784837 0.241150912077791 no 2576 0.193272405093978 3871 89219
SGTC_1209 2323-2347 50.3 µM -0.867751565968136 0.240651076166296 no 2577 0.19276517495284 3896 5412760
SGTC_1035 k081-0041 55.2 µM -0.868260296373295 0.240513815583842 no 2578 0.19262592611454 3902 731709
SGTC_2218 6965428 192.983 µM -0.868882845915444 0.240345903474564 no 2579 0.192455606563146 3834 675684
SGTC_2315 7733312 200 µM -0.87015835880463 0.240002075692307 no 2580 0.192106934423042 3867 726316
SGTC_3034 9090421 49.47 µM -0.871332700144153 0.239685757039745 no 2581 0.191786260345795 3808 17173761
SGTC_938 3126-1755 342 µM -0.87259489239316 0.23934602885247 no 2582 0.191441962749754 3963 1777771
SGTC_2837 9008476 45.46 µM -0.872967712753418 0.239245731894242 no 2583 0.191340338258667 3932 2992805
SGTC_1344 1488-0097 29.1 µM -0.873580648172211 0.23908088857418 no 2584 0.191173334362309 3969 747966
SGTC_3095 9117207 49.47 µM -0.874279439247696 0.238893030930125 no 2585 0.190983046801049 3914 17015229
SGTC_2839 9003951 25.97 µM -0.875210195285935 0.238642939019053 no 2586 0.190729773433163 3984 2990634
SGTC_1427 4048-4900 550 nM -0.875240635826992 0.238634762139102 no 2587 0.190721493565296 3935 24132586
SGTC_2054 5233173 129 µM -0.876410729747448 0.238320569994534 no 2588 0.190403393679844 3971 6889
SGTC_82 0054-0107 293.755 µM -0.876484937877591 0.238300651364209 no 2589 0.190383230568197 3907 3104697
SGTC_166 k072-0058 166.424 µM -0.876983316644955 0.238166902286893 no 2590 0.190247849914941 3873 5846229
SGTC_1844 rapamycin 4 nM -0.878015030572976 0.23789015370132 no 2591 0.18996778098175 3860 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2123 5259487 200 µM -0.878205388339463 0.237839111106744 no 2592 0.189916134195107 3956 2173474
SGTC_2708 st078559 56 µM -0.879287217143302 0.237549143263129 no 2593 0.189622782519208 3911 17250902
SGTC_2663 amphotericin b 100 µM -0.880282812264018 0.237282460584625 no 2594 0.189353060656196 3915 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2716 st080858 38.6235 µM -0.880766162196837 0.237153048539722 no 2595 0.189222199004892 3922 5296050
SGTC_985 1493-0307 8.71 µM -0.881057306224835 0.237075116394326 no 2596 0.189143401856321 3972 3278274
SGTC_105 0111-0055 734.78 µM -0.881907242562781 0.236847689723722 no 2597 0.188913485077968 3956 5179370
SGTC_1664 st014217 9.02 µM -0.882028163406996 0.236815343374 no 2598 0.188880788706627 3973 3982782
SGTC_470 aa-861 153 µM -0.882796050342513 0.236609990170079 no 2599 0.188673237435045 3941 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2517 totarol 10 µM -0.882913264576084 0.236578652615938 no 2600 0.188641568108037 3963 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_425 3825-7017 13.1 µM -0.884010625873459 0.236285380792275 no 2601 0.188345238401492 4046 3397440
SGTC_2655 perillic acid 100 µM -0.884326739819071 0.23620093591426 no 2602 0.188259928794679 3980 5702197 An apoptosis inducer.
SGTC_1077 5-fluorocytosine 377 nM -0.885241747940446 0.235956599573736 no 2603 0.188013130144884 3969 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1368 1852-0141 284 µM -0.885724825559964 0.235827658653202 no 2604 0.187882913640592 3962 2838987
SGTC_35 0133-0054 64.071 µM -0.888466623993491 0.235096566476136 no 2605 0.187144900718342 3964 99677
SGTC_1827 berberine 7.24 µM -0.889960287244538 0.234698813109938 no 2606 0.186743605202997 3900 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_306 1672-3436 11.6 µM -0.890213479610503 0.234631426437057 no 2607 0.186675634030881 3984 6797378
SGTC_661 1304-0007 33.6 µM -0.890258449560594 0.234619458888351 no 2608 0.186663563151112 3960 3117130
SGTC_1338 1486-1223 76 µM -0.891498146696424 0.234289679633419 no 2609 0.186330992684928 3985 3444526
SGTC_1366 1683-0113 21.9 µM -0.892244368858934 0.23409129637894 no 2610 0.186130982627452 3959 708623
SGTC_2229 7354935 190 µM -0.893746367759246 0.233692271998474 no 2611 0.185728805267988 3885 318112
SGTC_3299 9121982 43.1275 µM -0.895274363333037 0.233286728489127 no 2612 0.185320220614338 4030 17594604 YPL160W CDC60
SGTC_796 1234-0020 70.7 µM -0.895351070667697 0.233266379986172 no 2613 0.185299723863706 3889 46495034
SGTC_1940 st075990 51.1 µM -0.895495109423205 0.233228172833099 no 2614 0.18526123947733 4078 1084979
SGTC_1180 1193-0155 285 µM -0.895987138619795 0.233097685307356 no 2615 0.185129816173377 4032 2921347
SGTC_2989 9073649 71.4286 µM -0.896738754006181 0.232898433071448 no 2616 0.184929168011617 3869 21367202
SGTC_2348 9022543 33.42 µM -0.89858099354578 0.232410458216906 no 2617 0.184437943112264 4021 3162678 YDL140C RPO21
SGTC_1933 st074711 15.9 µM -0.898673583406204 0.232385947909778 no 2618 0.184413275883256 3943 17250958
SGTC_3181 9108277 49.47 µM -0.89870139162384 0.232378586823423 no 2619 0.18440586778736 3890 17097298
SGTC_1170 0310-0127 64.8 µM -0.900979875791101 0.231775892360866 no 2620 0.183799509827497 3990 774975
SGTC_2957 9076800 11.52 µM -0.904293853084644 0.23090085039128 no 2621 0.182919802672399 3944 16459615
SGTC_2064 5220758 200 µM -0.905124160566728 0.230681900472791 no 2622 0.182699806893225 4037 788518
SGTC_444 curcumin 90.4 µM -0.906219151572692 0.230393331628116 no 2623 0.18240993406252 3932 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_392 N-ethylmaleimide 8.33 µM -0.907847752688867 0.229964511203272 no 2624 0.181979332454217 3923 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3281 9140613 49.47 µM -0.907870872175666 0.229958426921482 no 2625 0.181973224248617 4004 16013766
SGTC_172 1112-0046 2.638 µM -0.908803835966439 0.229712976999533 no 2626 0.181726840696494 3946 2802135 YIL048W NEO1
SGTC_687 k029-0044 34.9 µM -0.909252194763245 0.229595072195686 no 2627 0.181608509280645 4066 5829338
SGTC_2891 9063876 19.48 µM -0.911224941587238 0.229076702395688 no 2628 0.181088432481697 3974 6472478
SGTC_2409 alverine citrate 63.97 µM -0.912393939769869 0.228769840054296 no 2629 0.180780689291848 4170 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1210 3013-0140 750 nM -0.914267228479416 0.228278582793439 no 2630 0.180288223057773 4024 905973
SGTC_381 3461-2219 42.7 µM -0.914525407268456 0.22821092368024 no 2631 0.180220416868434 3987 2883159
SGTC_3144 9087057 49.47 µM -0.914791985401118 0.228141075241072 no 2632 0.180150421534462 3825 17249618
SGTC_3262 9137218 49.47 µM -0.916546033571147 0.22768178181157 no 2633 0.179690287321548 3795 17650664
SGTC_1219 1469-0211 33.1 µM -0.922396536352276 0.226153610704087 no 2634 0.17816088789381 4017 6822282
SGTC_2886 9058944 51.95 µM -0.92244924963971 0.226139868213791 no 2635 0.178147145341499 3852 4949929
SGTC_617 3770-0098 35 µM -0.922755747212825 0.226059972853991 no 2636 0.178067253509604 3922 5962639
SGTC_2162 5663267 200 µM -0.925010736472411 0.225472650854403 no 2637 0.177480161353552 3965 6456493
SGTC_1253 0550-0034 176 µM -0.92653794034531 0.225075374879646 no 2638 0.177083244747448 4030 5969915
SGTC_1724 st037281 8.293 µM -0.926726600435373 0.225026325722625 no 2639 0.177034251390573 3985 574124 YDL195W SEC31
SGTC_2931 9014674 55.67 µM -0.92773566254187 0.224764085630682 no 2640 0.176772352308606 4000 2996810
SGTC_1831 st055328 12 µM -0.929213061061586 0.224380444730785 no 2641 0.176389339972762 4005 1103068
SGTC_1796 st049173 110.4 µM -0.92999809852333 0.224176742802286 no 2642 0.176186034501013 3932 94134
SGTC_2897 9048598 12.99 µM -0.930133927800552 0.224141508411191 no 2643 0.176150873102247 3986 6467404
SGTC_2351 9026858 72.31 µM -0.930596516958777 0.224021535439785 no 2644 0.17603115844499 3918 1409300
SGTC_1261 0712-0010 12.7 µM -0.935983098628471 0.222627208436207 no 2645 0.174640944902036 4033 2840123
SGTC_1714 st033236 13.627 µM -0.936793644405361 0.222417826174479 no 2646 0.174432357595148 4052 2916566
SGTC_1507 4075-3230 155 µM -0.93692984286266 0.222382654065572 no 2647 0.174397323575818 3889 659771
SGTC_3207 9114163 49.47 µM -0.937142344763063 0.222327783569737 no 2648 0.174342671124012 4067 849233
SGTC_1120 ficusin 1.78878 µM -0.938428868397201 0.221995752973476 no 2649 0.174012028026312 4089 6199 A DNA cross-linker.
SGTC_3125 9127534 49.47 µM -0.939786289316526 0.221645732100678 no 2650 0.173663596499602 3901 1639235
SGTC_959 1222-0044 107 µM -0.940047157727769 0.221578501425897 no 2651 0.173596686003208 4009 6083612
SGTC_1245 0418-0076 17.2 µM -0.940339592970083 0.22150314924554 no 2652 0.173521698391459 4080 6790114
SGTC_3132 9126706 49.47 µM -0.94291092086084 0.22084122271729 no 2653 0.172863234222354 4098 850858
SGTC_3303 9125618 40.5795 µM -0.942951152411675 0.220830875078966 no 2654 0.172852944418053 4058 22695467
SGTC_1155 4088-0394 48.2 µM -0.943564183637961 0.220673236523502 no 2655 0.172696201056877 4004 2326248
SGTC_1072 oxiconazole 14.9 nM -0.945116327659895 0.220274397160707 no 2656 0.172299745204808 4017 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.94986604056142 0.219056480366655 no 2657 0.171090162082626 4090 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_872 0588-0139 234 µM -0.951632881864236 0.21860441870133 no 2658 0.170641599664826 3991 2047100
SGTC_2689 tacrolimus 100 µM -0.952564976244264 0.218366150836905 no 2659 0.170405264886103 4060 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2437 5741531 144.16 µM -0.954763472486454 0.217804750236264 no 2660 0.1698486616843 4068 2262990
SGTC_833 3852-0053 558 µM -0.956513042475198 0.217358581417938 no 2661 0.169406549114634 4108 3123681
SGTC_2398 5228213 48.84 µM -0.957380586565691 0.217137539429232 no 2662 0.169187596749238 4057 80771 YMR134W ERG29
SGTC_2291 7917025 104.35 µM -0.959033472287003 0.216716759476356 no 2663 0.168770941531769 3969 2964612
SGTC_4 0960-0234 25.671 µM -0.961833020045401 0.216005147228055 no 2664 0.168066744212771 4048 6821112
SGTC_1346 1488-2224 62.4 µM -0.961883614292171 0.215992299228378 no 2665 0.16805403517183 4054 3722427
SGTC_1034 k072-0165 12.7 µM -0.962006769821654 0.215961026728466 no 2666 0.168023101657125 4087 5835461
SGTC_1876 myriocin 605 nM -0.962186963135682 0.215915275528972 no 2667 0.167977848315392 4046 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2038 4100038 30.985 µM -0.962563575734952 0.215819671482813 no 2668 0.167883292012231 4044 3596803
SGTC_2813 7971799 71.43 µM -0.96285226931865 0.21574640251222 no 2669 0.16781083278243 4093 2234054
SGTC_2740 felodipine 17.08 µM -0.964452517986596 0.21534052905954 no 2670 0.167409551431359 4053 3333 L-type calcium channel blocker
SGTC_1080 nisoldipine 24.4 µM -0.965284350369715 0.215129725297442 no 2671 0.167201204032129 4034 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_855 0428-0020 25 µM -0.965729438472518 0.215016979859599 no 2672 0.167089792378684 4072 6812414
SGTC_2247 cerulenin 830 nM -0.966401796640429 0.214846729634809 no 2673 0.16692158270425 4104 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2461 5755302 26.15 µM -0.967132366067889 0.214661828331492 no 2674 0.166738933675034 4107 2788904
SGTC_1067 clotrimazole 1.36 µM -0.967799742444319 0.214493001543094 no 2675 0.166572196236336 4080 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_312 4092-0653 6.84 µM -0.973919455422909 0.212948495799738 no 2676 0.165048266436269 4018 1148278
SGTC_412 gemfibrozil 100 µM -0.974432152002495 0.212819395680699 no 2677 0.16492100590336 3987 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1555 citronellol 128 µM -0.975559689357282 0.212535635686155 no 2678 0.164641354415142 4018 8842 A terpine precursor.
SGTC_605 1315-0399 119 µM -0.976687351579922 0.212252065424006 no 2679 0.164361979450198 4137 24020461
SGTC_2318 6029776 164 µM -0.978791081625361 0.211723637459827 no 2680 0.163841608599888 4095 818325
SGTC_2491 paeonol 100 µM -0.980019369364282 0.21141546484942 no 2681 0.163538278830133 3945 11092 Increases levels of cortical cytochrome oxidase.
SGTC_407 eburnamonine 100 µM -0.98255543408726 0.210780007884086 no 2682 0.162913143714505 3916 3195
SGTC_318 1488-0629 67.2 µM -0.98264153010923 0.21075845464582 no 2683 0.162891948513546 4122 3662576
SGTC_2651 TUB2.036 5 µM -0.98379180635345 0.210470619057845 no 2684 0.162608944420247 4043 15992207 YFL037W TUB2
SGTC_1530 rhein 70.4 µM -0.992621794061216 0.208268771736718 no 2685 0.160447149900091 4133 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1410 3909-8106 77.9 µM -0.993080050346296 0.208154873037815 no 2686 0.160335472585649 4143 1039210
SGTC_1873 rapamycin 2 nM -0.994293405913002 0.207853473470814 no 2687 0.16004002253028 4043 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1972 st070201 17.4 µM -0.994876116530347 0.207708818825235 no 2688 0.159898260084745 4084 2829099
SGTC_39 0986-0283 58.349 µM -0.995496267139449 0.207554935256467 no 2689 0.159747479446327 4164 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3334 9142812 21.919 µM -0.995673932164026 0.207510862048809 no 2690 0.159704299917448 4081 45283678
SGTC_828 2074-0507 139 µM -0.995973593158093 0.207436537940946 no 2691 0.159631487915791 4161 X828
SGTC_185 k048-0037 25.491 µM -0.998450334090445 0.206822841327509 no 2692 0.159030518256283 4140 6827589
SGTC_2752 diclazuril 33.15 µM -1.00084749253046 0.206229888726275 no 2693 0.158450272446789 4055 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2479 5617353 43.85 µM -1.00109339314706 0.206169120661574 no 2694 0.158390829438489 4147 2731746
SGTC_1628 st004252 77.7 µM -1.00145528611587 0.206079707356294 no 2695 0.158303373525305 4121 692968
SGTC_313 3474-0040 5.03 µM -1.00166627516894 0.206027588664815 no 2696 0.158252400034009 4092 1043375 YIL048W NEO1
SGTC_1139 k015-0024 46.9 µM -1.0021527628688 0.205907445863858 no 2697 0.15813490903305 4116 2766652
SGTC_107 0358-0022 2.6945 µM -1.00217293056051 0.205902466156397 no 2698 0.158130039596732 4128 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_3119 9125183 49.47 µM -1.0037540196479 0.205512293783956 no 2699 0.157748596079395 3902 22695334
SGTC_2887 9044784 58.44 µM -1.00484995725197 0.205242102184035 no 2700 0.157484552078181 4059 6465546
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.00628590108947 0.204888405313335 no 2701 0.157139030299619 4130 368090
SGTC_1661 st013063 9.66 µM -1.0082339239129 0.204409154647034 no 2702 0.156671087809547 4147 721395
SGTC_1369 1866-0067 208 µM -1.01044751933614 0.203865378801776 no 2703 0.156140465500709 4123 3531355
SGTC_3251 9135047 49.47 µM -1.01096408207203 0.203738607915561 no 2704 0.156016810541014 4123 17682963
SGTC_3041 9091929 49.47 µM -1.01253187856886 0.203354139136872 no 2705 0.155641906205296 4109 25236887
SGTC_632 0781-2353 4.65 µM -1.01407081043421 0.202977170143188 no 2706 0.155274482562306 4177 6811515 YHR007C ERG11
SGTC_675 1309-0189 238 µM -1.01709293443295 0.202238101456254 no 2707 0.154554610587852 4134 4246530
SGTC_1945 st075991 56.6 µM -1.01888938201786 0.201799539179347 no 2708 0.154127742557748 4115 1084980
SGTC_891 0929-0073 133 µM -1.01953575276666 0.201641881716594 no 2709 0.153974344290624 4151 5603632
SGTC_907 3448-6986 75.5 µM -1.01969307709942 0.201603519620458 no 2710 0.153937022991809 4143 590582
SGTC_3255 9139072 49.47 µM -1.02031719744783 0.201451376677951 no 2711 0.153789024890717 4134 17646060
SGTC_1949 st076024 69.1 µM -1.02433824039681 0.200472810562565 no 2712 0.152837770901536 4046 2921930
SGTC_925 2064-1272 59.6 µM -1.02534109491441 0.200229200145296 no 2713 0.152601135864316 4092 6815817
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.03028000421839 0.199032052740487 no 2714 0.151439291421374 3996 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1391 3442-0225 151 µM -1.03074213427927 0.198920257632413 no 2715 0.151330880232297 4094 5227075
SGTC_1618 st003135 44.5 µM -1.03190977401167 0.198637959475204 no 2716 0.151057193394203 4061 1270615
SGTC_380 3970-0968 6 µM -1.03204287618561 0.198605794949764 no 2717 0.151026016072643 4010 2891601
SGTC_49 0717-0965 32.132 µM -1.03439303510414 0.198038389781113 no 2718 0.150476229562133 4213 5889349 YGL099W LSG1
SGTC_3063 1327-0034 4 µM -1.03471862147842 0.197959859866294 no 2719 0.150400168507258 4019 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_847 0342-0274 5.54 µM -1.036057484726 0.197637130042602 no 2720 0.150087662568776 4130 18097
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.03768798304721 0.197244532028184 no 2721 0.149707670679839 4167 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1916 st067606 49.2 µM -1.041216520614 0.196396533238472 no 2722 0.148887534996812 4079 19590279
SGTC_1640 st009078 66.4 µM -1.04181385760915 0.196253196729277 no 2723 0.148748994045592 4101 690618
SGTC_2262 9014885 67.46 µM -1.04551967325465 0.195365370278556 no 2724 0.147891426436838 4093 6457424
SGTC_3232 9132874 49.47 µM -1.04629052525596 0.19518099925042 no 2725 0.147713459260777 4093 3784940
SGTC_1488 4013-0813 75.9 µM -1.0470217768398 0.195006197550915 no 2726 0.14754476727475 4064 2910057
SGTC_729 4092-0585 94.1 µM -1.04712981781351 0.194980379018322 no 2727 0.14751985431486 4146 2169061
SGTC_3242 9133940 49.47 µM -1.05099495267272 0.194058096091139 no 2728 0.146630453994618 4156 17248444
SGTC_3118 9124250 49.47 µM -1.05401746654555 0.193338731152325 no 2729 0.145937460217504 4074 1504786
SGTC_731 3966-0296 387 µM -1.05420169391876 0.193294937309985 no 2730 0.145895292342214 4141 660956
SGTC_3355 9151058 44.0485 µM -1.05462528009437 0.193194266952102 no 2731 0.145798368596319 4134 17015728
SGTC_3074 9116018 49.47 µM -1.05531949245434 0.193029348242191 no 2732 0.145639614568579 4203 17027303
SGTC_637 1181-0519 7.26 µM -1.0554202199443 0.193005426327843 no 2733 0.145616589640666 4135 6252091 YGR060W ERG25
SGTC_2200 6600604 21.907 µM -1.05722606222054 0.192576861508517 no 2734 0.145204214038287 4147 2904777
SGTC_2354 9060492 162 µM -1.05805468713738 0.192380406009658 no 2735 0.145015255524098 4194 6471895
SGTC_726 3448-4391 34.2 µM -1.06338137549724 0.191120450156977 no 2736 0.143804517673111 4281 1356692
SGTC_94 0334-0113 514.748 µM -1.06408227570169 0.190955039240138 no 2737 0.143645714697571 4172 6795178
SGTC_2742 clothiapine 36.27 µM -1.06476279567529 0.190794522062008 no 2738 0.143491642551277 4145 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1642 st009582 77.7 µM -1.06574143761395 0.190563830768238 no 2739 0.143270270169293 4158 6739311
SGTC_2049 5262831 67.185 µM -1.06735273075478 0.190184380437993 no 2740 0.142906292517734 4155 763417
SGTC_1290 0986-0249 10.2 µM -1.06782930919284 0.190072237959461 no 2741 0.142798757289581 4028 53329
SGTC_379 3970-0972 5.9 µM -1.0724215850571 0.18899372461572 no 2742 0.141765358577844 4165 2898042 YBL034C STU1
SGTC_2710 st078562 53.7235 µM -1.07243179011995 0.188991332123908 no 2743 0.141763067789708 4105 17250908
SGTC_1817 st052116 64.4 µM -1.07269773469462 0.188928990216584 no 2744 0.141703378547682 4195 4361398
SGTC_2739 tacrine 100.86 µM -1.07300439003129 0.188857120747397 no 2745 0.141634573218469 4215 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2070 5230947 200 µM -1.07333319660267 0.188780078508754 no 2746 0.141560822887203 4256 2835538
SGTC_164 4100-3994 89.624 µM -1.07492958702164 0.188406305728323 no 2747 0.141203127149199 4121 4615967
SGTC_245 methotrexate 289.6 µM -1.07526891774083 0.188326914988158 no 2748 0.141127173940858 4154 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2797 7859098 81.82 µM -1.07728577961854 0.187855470466605 no 2749 0.140676306630326 4161 972681
SGTC_638 3970-0837 4.09 µM -1.07733658794391 0.187843603362296 no 2750 0.140664961121132 4139 4118451 YLR208W SEC13
SGTC_2717 st081029 62.2815 µM -1.07784530929231 0.187724808806559 no 2751 0.140551397779219 4148 5292846
SGTC_1312 1218-2183 165 µM -1.07792013105627 0.187707340645679 no 2752 0.140534700351274 4218 6744073
SGTC_857 0438-0306 1.35 µM -1.07826007361375 0.187627989065804 no 2753 0.14045885480489 4241 4686136
SGTC_1814 st052110 31.539 µM -1.07903985221511 0.187446046436282 no 2754 0.140284981198593 4128 674163
SGTC_2496 diffractaic acid 79.83 µM -1.08049984970512 0.187105684390122 no 2755 0.139959826842456 4201 94870 An apoptosis inducer which activates caspases.
SGTC_47 0149-0135 24.25 µM -1.0831135821614 0.186497313243836 no 2756 0.139379005523758 4197 5239155
SGTC_2876 9059903 25.97 µM -1.0841115055585 0.186265360590402 no 2757 0.13915768103084 4163 6916095
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.0857468032507 0.185885646309566 no 2758 0.138795513827457 4064 6708630 An antioxidant.
SGTC_1215 3852-0577 11.2 µM -1.0858277782665 0.185866856484025 no 2759 0.138777597093991 4229 2884876
SGTC_1282 0886-0010 32.4 µM -1.09265207108834 0.184287549983031 no 2760 0.137273295487465 4235 2836211 YNL267W PIK1
SGTC_249 wiskostatin 11.211 µM -1.09295540655277 0.184217545194717 no 2761 0.137206689744924 4149 2775510 A n-wasp and actin depolymerizer.
SGTC_128 0906-2981 13.371 µM -1.09523402244367 0.183692207723969 no 2762 0.136707061975766 4174 6740226
SGTC_2098 5376439 882.5 nM -1.09616037548332 0.183478903115445 no 2763 0.136504298387134 4229 2844116
SGTC_29 0299-0004 12.984 µM -1.09723589627292 0.18323144450203 no 2764 0.136269142567981 4080 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2834 9001755 58.44 µM -1.09853921942079 0.182931851618925 no 2765 0.135984550878127 4113 2989575
SGTC_92 0063-0024 660.874 µM -1.09871215189768 0.182892122881041 no 2766 0.135946820201025 4274 3594437
SGTC_2117 5521686 200 µM -1.10014706499038 0.182562680076343 no 2767 0.135634025109491 4152 803312
SGTC_790 1575-0012 79.1 µM -1.102378497125 0.182051100692047 no 2768 0.13514857791062 4256 378741 YLR208W SEC13
SGTC_27 0485-0001 32.618 µM -1.10341164295805 0.181814544950123 no 2769 0.134924221402203 4142 2054479
SGTC_1224 0823-0416 294 µM -1.10349214352539 0.181796121098307 no 2770 0.134906750746464 4271 3598164
SGTC_2639 lactacystin 53 µM -1.10493008961496 0.18146722073816 no 2771 0.134594941553903 4253 3870 A proteasome inhibitor.
SGTC_894 0960-0238 55.9 µM -1.10583873163729 0.18125957988937 no 2772 0.134398163723362 4194 6741907 YDL195W SEC31
SGTC_9 0092-0002 10.449 µM -1.10673516899864 0.181054873892968 no 2773 0.134204222626902 4186 759368
SGTC_2937 9044753 11.33 µM -1.10938121706702 0.180451480662708 no 2774 0.133632880863982 4142 6465530 YGL099W LSG1
SGTC_2627 acetyl isogambogic acid 100 µM -1.11059159004718 0.180175893487607 no 2775 0.133372092187144 4227 6857789 A caspase activator and apoptosis inducer.
SGTC_843 0310-0051 143 µM -1.11141216871673 0.179989208071448 no 2776 0.133195488410838 4234 2065037
SGTC_2920 7982904 15.77 µM -1.11199041192058 0.179857728066368 no 2777 0.133071136425144 4213 6456808
SGTC_3201 9113999 49.47 µM -1.11257830435269 0.179724115896728 no 2778 0.132944791304399 4221 16649224
SGTC_3284 9108171 64.8615 µM -1.114446576886 0.179299921828169 no 2779 0.132543825548099 4187 8687505
SGTC_76 0433-0009 400.328 µM -1.11464841551585 0.179254131779185 no 2780 0.13250055717639 4271 2841569
SGTC_572 0960-0087 17.7 µM -1.11605512864002 0.178935202580086 no 2781 0.132199268807092 4184 6796365
SGTC_714 4296-0578 26.1 µM -1.11676733954632 0.178773866781289 no 2782 0.132046908442518 4243 1589775
SGTC_711 k292-0785 179 µM -1.11763713845495 0.178576957122759 no 2783 0.131861000224831 4143 4146315
SGTC_2121 5257820 149.641 µM -1.11912419745679 0.178240625398835 no 2784 0.131543579070466 4267 791256
SGTC_2048 5246248 200 µM -1.12125077943529 0.177760345390759 no 2785 0.131090565186007 4245 677046
SGTC_552 k242-0005 476 µM -1.12322119632297 0.177316064058494 no 2786 0.130671781250458 4290 4088318
SGTC_588 3970-1144 52.9 µM -1.1235258817382 0.177247427515172 no 2787 0.130607107381972 4086 1888707
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.12409372984642 0.177119553042807 no 2788 0.130486632510175 4265 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1931 st074438 57.1 µM -1.12499902276401 0.176915809472474 no 2789 0.130294724190407 4208 2787313
SGTC_1396 3511-0007 98.6 µM -1.12639163585597 0.176602679811888 no 2790 0.129999892785337 4233 X1396
SGTC_1632 st005650 90 µM -1.12674169885392 0.176524023150601 no 2791 0.129925853312137 4243 2759605
SGTC_710 3448-4187 58 µM -1.12697604714979 0.176471379142044 no 2792 0.129876304194149 4189 3946412
SGTC_3131 9127911 49.47 µM -1.12729070021615 0.176400711087696 no 2793 0.129809796522635 4275 45595681
SGTC_1684 st024538 14.6195 µM -1.12752708670578 0.176347632733146 no 2794 0.129759847437249 4176 6732859
SGTC_1459 k035-0031 35.7 µM -1.12813163559379 0.176211932962225 no 2795 0.129632165222805 3965 3877128 YMR208W ERG12
SGTC_345 1362-0200 395 µM -1.12852590417344 0.176123469272215 no 2796 0.129548941626806 4211 1419823
SGTC_1101 ebselen 5.29 µM -1.13032378932838 0.175720426735839 no 2797 0.129169906986209 4260 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3176 9106582 49.47 µM -1.13259388310693 0.17521236180859 no 2798 0.128692419286561 4186 17018027
SGTC_2395 5646831 180.19 µM -1.13264987241199 0.175199842743252 no 2799 0.128680658086311 4246 6808628
SGTC_2092 5303694 80.6725 µM -1.13418459764283 0.174856903029947 no 2800 0.128358561704973 4221 1963699
SGTC_1877 wortmannin 25 µM -1.13644187004707 0.174353282322748 no 2801 0.127885840440811 4231 312145 A covalent inhibitor of PI 3-kinase.
SGTC_785 1270-0111 65.3 µM -1.14352065086148 0.172779917269667 no 2802 0.126411242829533 4155 6741994
SGTC_2536 dehydroabietamide 32.04 µM -1.14621547226391 0.172183338612351 no 2803 0.125853003747636 4332 3983547
SGTC_2711 st079103 59.1 µM -1.14688749027007 0.172034772513135 no 2804 0.125714061764545 4194 54693780
SGTC_2412 st077135 33.4 µM -1.14788109133721 0.17181526255741 no 2805 0.125508827535085 4311 13258915
SGTC_2576 guaiol 23.12 µM -1.15007558072394 0.171331082117399 no 2806 0.125056371501301 4152 227829
SGTC_244 nsc-207895 1.295 µM -1.15388744069887 0.170492129284568 no 2807 0.124273159436423 4009 42640
SGTC_1715 st032160 10.2275 µM -1.15449587741456 0.170358462224468 no 2808 0.12414846388404 4185 5289825
SGTC_1491 4138-0063 26.5 µM -1.15504204259566 0.170238532744741 no 2809 0.124036605095977 4217 23883227
SGTC_2779 methotrexate 400 µM -1.15615491764006 0.169994329936805 no 2810 0.123808898113859 4261 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2984 9022109 38.96 µM -1.15651469886197 0.169915429699418 no 2811 0.123735345388269 4273 6459207
SGTC_80 0159-0065 512.242 µM -1.1568841544845 0.169834432297479 no 2812 0.123659846697245 4161 1548079
SGTC_1740 st038286 13.222 µM -1.15852873869798 0.169474183225458 no 2813 0.123324165372923 4287 716786
SGTC_1121 fusaric acid 630.51 nM -1.15901818529889 0.169367063835562 no 2814 0.123224386260299 4202 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2777 climbazole 1.536 µM -1.15976664976627 0.169203340324596 no 2815 0.123071912911794 4107 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2519 cryptotanshinone 88.04 µM -1.15976849705589 0.169202936363369 no 2816 0.123071536755088 4229 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1343 1487-0095 224 µM -1.16377615514743 0.168328008514578 no 2817 0.122257368892118 4263 4560101 YGL055W OLE1
SGTC_3305 9127027 53.8275 µM -1.16490902813496 0.168081214954544 no 2818 0.122027909332672 4188 41905295
SGTC_471 1-acyl-paf 4 µM -1.16828047674708 0.167348131618893 no 2819 0.121346823889328 4200 16759367
SGTC_1970 st070122 35.8 µM -1.17085366460084 0.166790009647395 no 2820 0.120828801314982 4285 102928
SGTC_775 4577-0580 57.3 µM -1.1721893131528 0.166500782766838 no 2821 0.120560529029698 4314 2006902
SGTC_3306 9127676 59.7925 µM -1.17218970785381 0.166500697344526 no 2822 0.12056044981389 4233 41905287
SGTC_90 0870-0863 4.608 µM -1.17331499807041 0.166257273861697 no 2823 0.120334755001823 4287 1738164
SGTC_525 k781-2675 26.7 µM -1.17353471382627 0.166209771646596 no 2824 0.120290722272157 4216 3651118 YDL195W SEC31
SGTC_2257 7960413 200 µM -1.17360781181676 0.166193969914919 no 2825 0.120276075388561 4282 2974689 YIL048W NEO1
SGTC_912 3474-0017 2.18 µM -1.17412161294994 0.16608292792964 no 2826 0.120173158826833 4299 3360550
SGTC_1511 0906-3109 28.5 µM -1.17941314617795 0.164942118972549 no 2827 0.119116851447392 4270 2882180
SGTC_865 0488-0499 301 µM -1.17987446926905 0.164842902737842 no 2828 0.119025072736831 4221 9634651
SGTC_2814 7977482 42.97 µM -1.17990117656085 0.164837160014785 no 2829 0.119019760938437 4282 6456762
SGTC_2251 lansoprazole 556 µM -1.18319522693645 0.164129852032529 no 2830 0.118365892103535 4206 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_958 1222-0007 33 µM -1.1877141021185 0.163162753639235 no 2831 0.117473032973646 4345 7312461
SGTC_1749 st037932 54.2 µM -1.19052007563651 0.16256410610283 no 2832 0.116921022124646 4310 594497
SGTC_740 k014-0057 261 µM -1.19226933078433 0.162191630899507 no 2833 0.116577828017432 4266 4012779
SGTC_3270 9137563 49.47 µM -1.19568550374495 0.161465816475866 no 2834 0.115909655216978 4269 17015724
SGTC_1022 4477-0945 21.3 µM -1.19671499480663 0.161247502428967 no 2835 0.115708830231075 4231 4648966
SGTC_1884 5633444 25 µM -1.19693834647293 0.161200163868571 no 2836 0.115665293196902 4252 5724239
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.20102525281913 0.160335560183063 no 2837 0.114870702876466 4345 91467 include heat shock
SGTC_145 3737-0113 38.366 µM -1.20134307240988 0.160268451233516 no 2838 0.114809074423079 4244 6849351
SGTC_1385 3091-4834 14.1 µM -1.20407618726881 0.159692100379986 no 2839 0.114280066404021 4259 4072814
SGTC_24 0417-1663 219 µM -1.20531276836455 0.159431780137827 no 2840 0.114041291144494 4319 4329390
SGTC_1976 st070609 63.5 µM -1.20539646498714 0.159414170694325 no 2841 0.114025142756723 4236 682556
SGTC_197 4544-0043 41.561 µM -1.20701286859947 0.159074335447508 no 2842 0.113713594066403 4293 896523
SGTC_1485 3909-9022 254 µM -1.20787289834631 0.158893715021992 no 2843 0.113548077829118 4352 714516
SGTC_2585 alliin 100 µM -1.20958727426689 0.158534068975505 no 2844 0.113218651840604 4355 87310 A garlic compound which reacts with lipids.
SGTC_2152 5568786 200 µM -1.21143011773801 0.158148068532902 no 2845 0.112865301191694 4292 5399883
SGTC_836 0330-0104 1.35 µM -1.21169034411194 0.158093611479443 no 2846 0.112815468347297 4327 46494820
SGTC_3208 9114115 49.47 µM -1.21229483187534 0.157967159043553 no 2847 0.112699770748001 4301 650895
SGTC_762 1165-0429 115 µM -1.21283692299539 0.157853815819158 no 2848 0.112596087809475 4297 5967793
SGTC_2770 toltrazuril 17.5 µM -1.21552558426425 0.157292446098508 no 2849 0.112082848498024 4256 68591 Kills coccidiodes.
SGTC_2843 9000894 45.46 µM -1.21610911383822 0.157170783611928 no 2850 0.111971679594887 4234 2242070
SGTC_3331 9141060 1.957 µM -1.21721668963043 0.156940030809109 no 2851 0.111760890914243 4253 4906567 YPR165W RHO1
SGTC_2563 tomatine 8.54 µM -1.22178843177388 0.155989911992528 no 2852 0.110893822166426 4278 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_158 k038-0087 26.446 µM -1.22216027230116 0.155912801586458 no 2853 0.110823512036552 4207 X158
SGTC_2248 tofa 1.1 µM -1.22318667435431 0.155700081954892 no 2854 0.110629598748377 4296 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_153 4077-0274 519.67 µM -1.22474915676488 0.155376628432643 no 2855 0.110334873396346 4356 3121976
SGTC_1602 st001878 87.6 µM -1.22509533359576 0.155305025518328 no 2856 0.110269651585685 4281 595405 YLR310C CDC25
SGTC_1736 st036774 51 µM -1.2254656078346 0.155228462425136 no 2857 0.110199920286629 4361 1272247
SGTC_3071 9117417 49.47 µM -1.22588355141363 0.155142072488006 no 2858 0.110121249740692 4251 45595590 YGL055W OLE1
SGTC_1113 artemisinin 1.17947 µM -1.22662908815281 0.154988047087433 no 2859 0.109981015578595 4348 2240 An anti-malaria and mitochondrial poison.
SGTC_2219 9098279 200 µM -1.22794439512016 0.154716555383276 no 2860 0.109733921170451 4242 902349
SGTC_1267 0828-0272 9.49 µM -1.22821736031015 0.154660252202184 no 2861 0.109682691727463 4371 745334
SGTC_1288 0973-0013 65.5 µM -1.22953693940022 0.154388260101131 no 2862 0.109435278463324 4340 4315430
SGTC_3269 9137823 49.47 µM -1.23089317755134 0.1541090415763 no 2863 0.10918140980455 4232 17682936
SGTC_251 melphalan 456.522 µM -1.23780112178344 0.152692040112808 no 2864 0.107894906202959 4358 460612 A DNA alkylator.
SGTC_1297 1068-0111 14.1 µM -1.23880935369526 0.152485950235201 no 2865 0.107708054540739 4311 767057
SGTC_2237 6667747 47.222 µM -1.23917448368911 0.152411360579504 no 2866 0.107640443964762 4331 729940 YDL015C TSC13
SGTC_587 k089-0003 57 µM -1.24281295239729 0.151669408304999 no 2867 0.106968384216189 4236 9659696
SGTC_3286 9117135 37.221 µM -1.24551227677362 0.151120518936143 no 2868 0.106471752808226 4292 3438150
SGTC_203 k066-0004 30.888 µM -1.24570327877474 0.151081730101411 no 2869 0.106436674743285 4394 6795412
SGTC_3101 9120531 49.47 µM -1.24628335977556 0.150963967416319 no 2870 0.106330192360769 4322 24824904
SGTC_20 0481-0013 4.944 µM -1.24671797686262 0.150875775514444 no 2871 0.10625046244286 4359 182045
SGTC_433 pimozide 108 µM -1.24903382613976 0.150406424895076 no 2872 0.105826351017591 4244 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2873 9040596 71.43 µM -1.25175603910878 0.149855962083551 no 2873 0.105329386655698 4287 6463863
SGTC_646 4092-0839 27.3 µM -1.25196985930102 0.149812782165684 no 2874 0.105290423499578 4350 877796
SGTC_928 2764-0428 58.7 µM -1.25378263021126 0.149447035604568 no 2875 0.104960512161544 4358 662578
SGTC_1634 st006576 41 µM -1.25577908169193 0.149044919671182 no 2876 0.104598038908095 4305 3915356
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.25958538557999 0.148280275960496 no 2877 0.103909485142025 4358 165521
SGTC_3195 9113082 49.47 µM -1.26117509001871 0.147961700449755 no 2878 0.103622885648791 4341 17018038
SGTC_1104 tacrolimus 29.8 µM -1.26222606333696 0.147751337981292 no 2879 0.103433726388934 4401 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_616 4092-0450 108 µM -1.26275623779258 0.147645294475804 no 2880 0.103338398192699 4340 787165
SGTC_2628 lathosterol 100 µM -1.2631441262178 0.147567742787198 no 2881 0.103268694198353 4394 6710616
SGTC_683 panaxydol 45 µM -1.26534834160566 0.147127565615073 no 2882 0.102873242279481 4348 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2999 9069765 71.4286 µM -1.26611196091672 0.146975277964344 no 2883 0.102736500482425 4286 2097066
SGTC_2374 9071832 200 µM -1.26736099973891 0.146726411647601 no 2884 0.10251311912294 4265 17381698
SGTC_3106 9121286 49.47 µM -1.26904409539289 0.146391508564288 no 2885 0.102212668712835 4302 15943471
SGTC_2068 5226020 147 µM -1.26978382771041 0.146244478791277 no 2886 0.102080821474704 4354 1810509
SGTC_2096 5468907 200 µM -1.27014921462622 0.146171890805678 no 2887 0.102015741895065 4331 759785
SGTC_2208 7283366 200 µM -1.27530363374861 0.145150489343327 no 2888 0.101100896041284 4331 898663
SGTC_1889 st059080 5.18 µM -1.27593540688915 0.145025628201942 no 2889 0.100989176764031 4317 176925 Isolated from Daphnopsis sellowiana.
SGTC_2399 5884133 200 µM -1.27594583970221 0.145023566909083 no 2890 0.10098733263855 4320 722445
SGTC_2787 5284540 71.43 µM -1.27715451510316 0.14478489289813 no 2891 0.100773850822908 4372 736958
SGTC_2065 5221596 34.26 µM -1.27853049645862 0.144513503564989 no 2892 0.100531219463859 4300 788581
SGTC_3214 9129694 49.47 µM -1.27916702914608 0.144388074154303 no 2893 0.100419121835861 4381 17158655
SGTC_2030 5175110 200 µM -1.27947996479477 0.144326436777026 no 2894 0.100364045247151 4355 2831986
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.28107626567658 0.144012297332398 no 2895 0.100083439740745 4184 88881 An O-methylated flavonoid and antioxidant.
SGTC_1550 gossypolone 36.6 µM -1.2819706751512 0.143836486308234 no 2896 0.0999264667148186 4381 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1143 3454-2408 5.08 µM -1.28214702231573 0.143801839443086 no 2897 0.0998955381990193 4362 X1143
SGTC_2549 cedrol 20.94 µM -1.28314968889197 0.143604952920567 no 2898 0.0997198191516197 4295 6708665 A sedative which affects the nervous system.
SGTC_1562 morin hydrate 59.1 µM -1.28670547165992 0.14290819628774 no 2899 0.0990984826085879 4385 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2009 4012297 12.05 µM -1.28699046273928 0.142852451268492 no 2900 0.0990488061821739 4329 45595307
SGTC_1327 1436-0082 2.18 µM -1.28711152340442 0.142828775925967 no 2901 0.0990277097671386 4367 15992205
SGTC_2139 5578692 56.4705 µM -1.29092311054781 0.142084715491407 no 2902 0.0983651703855624 4337 650991 YMR113W FOL3
SGTC_1699 st031318 29.054 µM -1.29155687336469 0.141961253415972 no 2903 0.0982553236701052 4415 5340658
SGTC_808 0711-0032 135 µM -1.29227125314308 0.141822173611988 no 2904 0.0981316118003172 4334 4252555
SGTC_2620 irigenin 100 µM -1.29464293874662 0.141361101269087 no 2905 0.0977217163198707 4372 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1666 st014829 29 µM -1.2962194866062 0.141055172049284 no 2906 0.0974499389167722 4353 3858230
SGTC_3261 9137475 49.47 µM -1.29859487527919 0.140595076197596 no 2907 0.0970414988101581 4340 17027690
SGTC_1611 st001856 99.4 µM -1.29888456387903 0.140539035349785 no 2908 0.0969917739211823 4338 647478
SGTC_1403 3909-7815 62.9 µM -1.29966373251063 0.140388378846005 no 2909 0.0968581228680329 4336 6615483
SGTC_394 menadione 8.33 µM -1.3013838208559 0.140056178771115 no 2910 0.0965635544082371 4380 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2160 5660466 132.927 µM -1.30559857834061 0.139244443296098 no 2911 0.0958445520316955 4300 2859134
SGTC_2100 5377183 190 µM -1.30699120503042 0.138976937310844 no 2912 0.0956078492426155 4385 2844202
SGTC_1936 st074407 74.3 µM -1.30977839676401 0.138442604440597 no 2913 0.0951354067057622 4400 809813
SGTC_610 4215-0184 155 µM -1.31070866630919 0.138264574389165 no 2914 0.0949781048174758 4377 5605015
SGTC_1875 nocodazole 6 µM -1.31071922190003 0.138262555212088 no 2915 0.0949763210430165 4403 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2217 6934799 96.0675 µM -1.31121395952452 0.13816793949145 no 2916 0.094892743710294 4351 675606
SGTC_451 chloral hydrate 100 µM -1.31488168700068 0.137467884636019 no 2917 0.0942748341448479 4388 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3129 9127257 49.47 µM -1.31534307465721 0.137379991894778 no 2918 0.0941973138493605 4317 837894
SGTC_1138 3761-0006 1.03 µM -1.31639629540544 0.137179500811341 no 2919 0.094020532595528 4404 12061087
SGTC_2806 7952793 58.44 µM -1.31753837437479 0.136962320658407 no 2920 0.0938291134383048 4403 2972490
SGTC_1005 4092-0690 4.4 µM -1.3185421496928 0.136771634729 no 2921 0.0936611124402928 4389 1529343
SGTC_1619 st003326 88.7 µM -1.31905115177202 0.136675009628175 no 2922 0.0935760061224327 4357 2849032
SGTC_1475 4092-1048 11.7 µM -1.31922692774378 0.136641652493309 no 2923 0.0935466292456432 4384 2881759
SGTC_2918 7977171 22.06 µM -1.32016164439069 0.136464364142927 no 2924 0.0933905274358316 4371 2236483
SGTC_2953 9074162 66.49 µM -1.32070320965073 0.136361717107138 no 2925 0.0933001717311307 4365 16451992
SGTC_3164 9100705 49.47 µM -1.32220720568144 0.136076930245262 no 2926 0.093049581146727 4376 17174235
SGTC_400 oxethazaine 37.5 µM -1.32265087116848 0.135992998464637 no 2927 0.0929757542541712 4413 4621 A local anesthetic.
SGTC_1820 st053765 18.6 µM -1.32269730771026 0.135984215738583 no 2928 0.0929680296175596 4420 3690829
SGTC_562 3772-2733 112 µM -1.3234571055409 0.135840567337765 no 2929 0.0928417059727796 4366 2876874 YIL048W NEO1
SGTC_216 k038-0035 28.382 µM -1.32636043767964 0.13529261684958 no 2930 0.0923601682967993 4297 4444231 YPR107C YTH1
SGTC_2524 avocatin b 10.57 µM -1.32681998081774 0.13520602562777 no 2931 0.0922841196291045 4383 6710748
SGTC_1390 3413-2614 145 µM -1.32829552104536 0.134928248068496 no 2932 0.0920402494080994 4399 3421432
SGTC_2541 muurolladie-3-one 83.07 µM -1.33367245042013 0.133919328990695 no 2933 0.0911556136804577 4342 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1464 k208-0027 110 µM -1.3337695292646 0.13390116103463 no 2934 0.0911397000006331 4395 X1464
SGTC_2544 sphondin 68.51 µM -1.33407022530898 0.133844897602478 no 2935 0.0910904213821205 4350 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.33648572998191 0.133393520500441 no 2936 0.0906952808271786 4448 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2145 5634607 200 µM -1.33703826041656 0.133290418355536 no 2937 0.0906050741294845 4368 308662
SGTC_2151 5563267 85.4165 µM -1.33740373668107 0.133222250642811 no 2938 0.0905454426979974 4456 5310824
SGTC_1711 st032263 62.8 µM -1.34251645694934 0.132271153730333 no 2939 0.0897142990127308 4379 3958979
SGTC_1377 2944-0135 198 µM -1.34996674358288 0.130893606650857 no 2940 0.0885133253319691 4409 1894137
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.35123259273064 0.130660541955982 no 2941 0.0883104685486797 4368 2333 A French combination drug.
SGTC_718 1130-0073 349 µM -1.35303233658236 0.130329672212896 no 2942 0.088022650039006 4419 6740020
SGTC_1467 k284-1082 293 µM -1.35560363911395 0.129857963380769 no 2943 0.0876126566801628 4378 3334705
SGTC_3013 9080133 71.4286 µM -1.35798650180185 0.129421880586936 no 2944 0.0872339836603922 4470 17050193
SGTC_1189 1431-2119 7.28 µM -1.36142226242786 0.128794897197316 no 2945 0.0866901423501899 4401 3107275
SGTC_3153 9100258 49.47 µM -1.36167901443718 0.128748127924039 no 2946 0.086649603447497 4326 25236848
SGTC_374 0880-0231 82.3 µM -1.36414895859601 0.12829881122064 no 2947 0.0862603443279059 4279 6833587
SGTC_3199 9111318 49.47 µM -1.36492455122397 0.128157945182014 no 2948 0.0861383824366705 4332 8548020
SGTC_1982 st072467 71.9 µM -1.36524919385079 0.12809901427512 no 2949 0.0860873707195735 4395 3163533
SGTC_154 3389-1638 511.116 µM -1.36530798080464 0.128088344958557 no 2950 0.0860781358303948 4402 5238686
SGTC_1320 1313-0481 95.3 µM -1.3664668034279 0.127878154818468 no 2951 0.0858962467378026 4380 6813365 YLR208W SEC13
SGTC_3197 9113331 49.47 µM -1.36816324164565 0.127570883080445 no 2952 0.0856304923437221 4406 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_513 4245-1575 41.7 µM -1.36880612866463 0.127454572752461 no 2953 0.0855299423237694 4250 719745
SGTC_1010 4112-3296 15.2 µM -1.37234324109227 0.12681596184194 no 2954 0.0849783052162418 4445 704384
SGTC_369 0957-0393 4.5 µM -1.37549805399476 0.126248256037366 no 2955 0.0844885443061936 4414 6997992
SGTC_1961 st076550 68.7 µM -1.37715720841088 0.125950404406177 no 2956 0.0842318242902643 4436 1579337
SGTC_1191 1487-1166 10.6 µM -1.37835488048882 0.125735702904336 no 2957 0.0840468733359546 4449 3955771
SGTC_2297 7971671 152.32 µM -1.37970010049054 0.125494855707438 no 2958 0.0838395009851069 4411 909016
SGTC_1892 st058411 7.36 µM -1.37977846935238 0.125480834535917 no 2959 0.0838274318919786 4415 3934738
SGTC_672 1441-0018 53.7 µM -1.38043974657218 0.125362567288209 no 2960 0.0837256447229881 4422 251141
SGTC_804 1595-0054 20.9 µM -1.3812959916173 0.125209546326591 no 2961 0.0835939850890897 4393 761523 Stimulates phospholipase C.
SGTC_514 4466-0038 2.65 nM -1.38249279469644 0.124995882300295 no 2962 0.0834102206630266 4213 5722064
SGTC_972 1319-0219 195 µM -1.38672603026263 0.124242171307863 no 2963 0.0827626600319284 4412 23903702
SGTC_736 0958-0254 92.6 µM -1.38681584609125 0.124226214465927 no 2964 0.0827489619492213 4481 6812352
SGTC_814 3342-0569 96 µM -1.38703815996473 0.124186723948459 no 2965 0.0827150635280339 4454 4346283
SGTC_2520 obtusaquinone 4.71 µM -1.38803704800136 0.124009395783776 no 2966 0.0825628820259782 4465 5967872
SGTC_867 0518-0118 155 µM -1.38887075912403 0.123861526466844 no 2967 0.0824360268182833 4422 6848158
SGTC_2089 5281248 129.67 µM -1.39400298027737 0.122953979790573 no 2968 0.0816583523380236 4414 2737878
SGTC_1774 st048371 48.465 µM -1.39417130661921 0.122924293288361 no 2969 0.081632940208705 4427 4242727
SGTC_2482 5981709 142.65 µM -1.39481680343281 0.122810498263157 no 2970 0.0815355452040545 4367 877755
SGTC_1878 temozolomide 1 mM -1.39668904925238 0.122480856874775 no 2971 0.0812535493266014 4377 5394 DNA alkylating agent.
SGTC_3081 9117243 49.47 µM -1.39924766522054 0.122031372870454 no 2972 0.0808693637466282 4403 45595589
SGTC_3060 1327-0027 12.5 µM -1.4022849038489 0.121499312321076 no 2973 0.0804150932717279 4347 16000455 YPR107C YTH1
SGTC_699 0375-0592 111 µM -1.4043724018307 0.121134573289168 no 2974 0.0801039923151333 4520 762578
SGTC_1739 st037196 92.5 µM -1.40661506076041 0.120743582639046 no 2975 0.0797707823490907 4454 612214
SGTC_1065 prochlorperazine maleate 2.48 µM -1.40753659471264 0.120583177943434 no 2976 0.0796341669147705 4470 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2988 9073640 71.4286 µM -1.4102783769738 0.120106823388299 no 2977 0.0792287503588374 4467 9102229
SGTC_575 k072-0246 11.9 µM -1.41163012477013 0.119872460761437 no 2978 0.0790294487516748 4526 6796779
SGTC_1525 8-methoxypsoralen 92.5 µM -1.4118434610566 0.119835502530581 no 2979 0.0789980291858945 4482 4114 Related to psoralen; DNA damaging agent.
SGTC_1766 st045414 44.774 µM -1.41188181591327 0.11982885881384 no 2980 0.0789923813944598 4442 253960
SGTC_457 grayanotoxin iii 135 µM -1.41455966422897 0.119365651579257 no 2981 0.0785988211250994 4276 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_12 0849-0099 9.267 µM -1.41611355001395 0.119097444497021 no 2982 0.0783711307407324 4387 6071388
SGTC_2720 fluspirilene 36.88 µM -1.41656948552653 0.119018828946202 no 2983 0.0783044176492505 4426 3396 An atypical antipsychotic.
SGTC_3296 9122258 64.045 µM -1.41883668486652 0.118628446907156 no 2984 0.0779733173852087 4416 4730474
SGTC_1239 0337-0584 35.4 µM -1.42114529882574 0.118231864395724 no 2985 0.0776372616281508 4501 914301 YML130C ERO1
SGTC_1644 st010134 20.9 µM -1.4242258000825 0.117704145475086 no 2986 0.0771905593207382 4426 3818134
SGTC_574 1315-0397 40 µM -1.42424421954187 0.117700995069852 no 2987 0.0771878942077186 4437 6794277
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.43272759715749 0.116256363447892 no 2988 0.0759678497898818 4404 676296 Flavone; oxidizing agent.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.43434556786175 0.115982274510894 no 2989 0.0757368363231206 4496 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2350 9023895 38.85 µM -1.4366507213694 0.115592567697211 no 2990 0.0754086318555435 4431 2997209
SGTC_2736 butenafine 14.65 µM -1.43843089179199 0.115292251217482 no 2991 0.0751559163924415 4403 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2776 terbinafine 19.92 µM -1.44219626396388 0.114658857435123 no 2992 0.0746235071288613 4470 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_423 5-fluorouracil 457 µM -1.4472993760726 0.113804392929605 no 2993 0.0739065469038582 4404 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1330 1469-0054 61.8 µM -1.44771832623908 0.113734446077105 no 2994 0.0738479212420147 4446 7102664
SGTC_2976 9009005 19.48 µM -1.45035995858946 0.113294111578444 no 2995 0.0734790834763103 4458 2993148
SGTC_1492 4158-0558 28.5 µM -1.45588170190729 0.112377621332559 no 2996 0.0727126624103896 4468 3967268
SGTC_592 k241-0073 46.5 µM -1.45652936968676 0.112270470558895 no 2997 0.072623168365634 4499 4230158
SGTC_2650 prasterone 100 µM -1.4604873815197 0.111617239619494 no 2998 0.0720780865098255 4479 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_454 lyso-paf C-16 6.67 µM -1.46307961798405 0.11119089283427 no 2999 0.0717227971459878 4489 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_252 miconazole 1.30953 nM -1.46368140431294 0.111092083639774 no 3000 0.0716405093614431 4383 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1522 st012842 45.6 µM -1.46390428629137 0.111055503907004 no 3001 0.0716100510439662 4317 3491067 YOR116C RPO31
SGTC_3103 9120822 49.47 µM -1.46624205937155 0.110672344663104 no 3002 0.0712911770227169 4477 17141819
SGTC_1798 st045719 60.953 µM -1.47254590852533 0.109643872662197 no 3003 0.0704367596949794 4432 3980186
SGTC_1994 st072947 40.9 µM -1.47339231190314 0.109506306325107 no 3004 0.0703226410612806 4525 5286565 YDL195W SEC31
SGTC_2780 5215298 71.43 µM -1.47472414984246 0.109290093125646 no 3005 0.0701433603322355 4490 2834131
SGTC_2684 capsaicin 100 µM -1.47849206924843 0.108680063275071 no 3006 0.0696380591475324 4504 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_464 bw-b 70c 158 µM -1.47938962540176 0.108535109897705 no 3007 0.0695181056464763 4481 5353454
SGTC_1451 4152-0210 104 µM -1.48042642734258 0.108367841805848 no 3008 0.0693797408245042 4515 659563
SGTC_2401 5128683 200 µM -1.48165981084935 0.108169100738566 no 3009 0.069215417878836 4477 708373
SGTC_2456 5770359 74.46 µM -1.4826781255878 0.108005212583207 no 3010 0.0690799745363836 4481 3118787
SGTC_1107 amlodipine 47 µM -1.48320331256568 0.107920758609245 no 3011 0.0690102006904155 4085 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1357 1503-1303 39.5 µM -1.48469561773274 0.107681044416006 no 3012 0.0688122365577377 4471 292895
SGTC_1950 st077106 7.18 µM -1.48768917769697 0.107201335510557 no 3013 0.0684164414873561 4390 13831864
SGTC_1257 0669-0121 16 µM -1.4899217269404 0.106844580758249 no 3014 0.0681224090030556 4477 4307855
SGTC_256 clotrimazole 625 nM -1.491463295905 0.10659874307264 no 3015 0.0679199503889318 4425 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_519 k048-0011 62.8 µM -1.49256036343845 0.106424039943615 no 3016 0.0677761526245188 4516 6836379
SGTC_247 mechlorethamine 29.705 µM -1.4931136878769 0.106336003958366 no 3017 0.0677037150748089 4444 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1726 st035556 14.5795 µM -1.49424055129557 0.106156878417799 no 3018 0.0675563785610669 4518 5919439
SGTC_2272 7805186 180 µM -1.49480764938405 0.106066815337897 no 3019 0.0674823247041695 4493 2956062 YPR165W RHO1
SGTC_2263 7948595 193.29 µM -1.49509013520615 0.106021973256971 no 3020 0.0674454600305622 4506 2971371
SGTC_548 1436-0017 110 µM -1.49636309565144 0.105820072193176 no 3021 0.0672795305267522 4521 9677137
SGTC_1874 staurosporine 7.6 µM -1.49894963896669 0.105410683409945 no 3022 0.0669433487042568 4487 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3059 1327-0034 3 µM -1.49994355073192 0.105253675710771 no 3023 0.0668145127518748 4349 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2469 5655019 90.81 µM -1.50089907575401 0.105102891542457 no 3024 0.0666908336396824 4556 2788239
SGTC_3278 9139605 49.47 µM -1.50130823956317 0.105038372326952 no 3025 0.0666379274167739 4483 7958859
SGTC_259 usnic acid 108.925 µM -1.50214065731395 0.104907200583714 no 3026 0.0665303933430056 4540 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1389 3405-0187 19 µM -1.50514012416293 0.104435530550387 no 3027 0.066144027553479 4479 799890
SGTC_612 0302-0167 22.4 µM -1.50612578524469 0.104280870016181 no 3028 0.0660174432159338 4499 235821
SGTC_1903 st060211 78.3 µM -1.50642901713512 0.10423332316779 no 3029 0.0659785381880124 4524 688960
SGTC_340 k038-0059 454 µM -1.50989084771226 0.103691620525027 no 3030 0.0655356392075229 4480 23733424
SGTC_3321 9137793 26.8275 µM -1.51201590305907 0.103360108060374 no 3031 0.0652649084578117 4466 4904192
SGTC_1241 0364-0022 50.8 µM -1.51773531372291 0.10247169331351 no 3032 0.0645405689430775 4505 4563895
SGTC_1941 st076221 61.8 µM -1.52111627811054 0.101949135199363 no 3033 0.0641153301041569 4388 2828568
SGTC_135 0933-0004 26.348 µM -1.52285623728278 0.101680966088455 no 3034 0.0638973382978674 4438 21230617 YGL099W LSG1
SGTC_422 cantharidin 155 µM -1.52306617658271 0.101648644202135 no 3035 0.0638710749462887 4417 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2662 daunorubicin 22.37 µM -1.53125975230958 0.100393013181103 no 3036 0.06285260420128 4394 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_813 k007-0158 173 µM -1.53161791747485 0.100338385228806 no 3037 0.0628083742028228 4518 6523916
SGTC_715 0868-0130 184 µM -1.53247238125489 0.100208148595957 no 3038 0.0627029539834594 4554 2876258
SGTC_1604 st002052 72.4 µM -1.53264426285744 0.100181965464619 no 3039 0.0626817646091188 4556 6254834 YHR062C RPP1
SGTC_1979 st071809 45.3 µM -1.53687385917503 0.0995392337588495 no 3040 0.0621621010378975 4558 4976333
SGTC_1217 1183-1422 255 µM -1.53687756275571 0.0995386722844161 no 3041 0.0621616474797995 4546 2849664
SGTC_1303 1160-0052 261 µM -1.53746793749472 0.0994491992140232 no 3042 0.0620893803824239 4469 3562476
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.54224971991596 0.0987266712157058 no 3043 0.0615064610476783 4506 688669
SGTC_1392 3455-1037 33.9 µM -1.54283105829719 0.0986390935029115 no 3044 0.0614358858299443 4518 981132
SGTC_1050 3232-1156 69.3 µM -1.54372402684236 0.0985046799777329 no 3045 0.0613276015400513 4476 700529
SGTC_3136 9095672 49.47 µM -1.54424304305841 0.0984266170392689 no 3046 0.0612647324875386 4374 17217380
SGTC_2036 5160441 105 µM -1.54493669029022 0.0983223593592812 no 3047 0.0611807888085083 4492 134534 YIL048W NEO1
SGTC_888 0916-0002 6.97 µM -1.54625858188881 0.0981238982619217 no 3048 0.0610210652501647 4531 2802138 YIL048W NEO1
SGTC_106 0092-0003 11.579 µM -1.54631575249165 0.0981153216267221 no 3049 0.061014164712748 4442 1072148
SGTC_743 1275-0778 158 µM -1.54638237684512 0.0981053274491439 no 3050 0.0610061238697299 4488 2849257 YMR203W TOM40
SGTC_1132 3456-3614 2.5 µM -1.54756362192381 0.0979282552125902 no 3051 0.0608636977894861 4506 3125502
SGTC_1959 st077091 55.8 µM -1.55233056016251 0.0972160563989058 no 3052 0.0602915746190389 4519 821356 YKL052C ASK1
SGTC_2765 myclobutanil 7.74 µM -1.55586029657325 0.0966911545900635 no 3053 0.0598706581609318 4532 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2584 androsterone 48.74 µM -1.5566426354017 0.0965750964905713 no 3054 0.0597776776304537 4423 2754130 A steroid.
SGTC_1545 lovastatin 49.4 µM -1.55998634429235 0.0960802185293335 no 3055 0.059381554133457 4553 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2199 6590217 200 µM -1.56127368283637 0.0958901868856424 no 3056 0.0592295951303178 4490 703109
SGTC_3174 9107204 49.47 µM -1.56150376234101 0.0958562526296795 no 3057 0.0592024684157437 4528 3938802
SGTC_1006 4099-6547 255 µM -1.56170852271196 0.095826060103164 no 3058 0.0591783350592517 4530 3146833
SGTC_2852 9023854 51.95 µM -1.56469493416179 0.0953864995923871 no 3059 0.0588272284375245 4528 19798528
SGTC_1594 piperine 70.1 µM -1.57214800050997 0.0942959838574793 no 3060 0.0579581158182336 4526 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_890 0929-0006 47.2 µM -1.57853034110893 0.0933694661633271 no 3061 0.0572219117078556 4537 1378169
SGTC_747 3448-8087 38.7 µM -1.58000581663015 0.0931562332311869 no 3062 0.0570527672087412 4571 5168703
SGTC_60 0986-0278 202 µM -1.58194922356559 0.0928759251887328 no 3063 0.0568305812668581 4481 3110598
SGTC_2781 5567276 71.43 µM -1.58500585130995 0.0924363138351779 no 3064 0.0564825024147062 4531 2853274
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.59495778650141 0.091015671291814 no 3065 0.0553608379580118 4566 77254
SGTC_1028 k015-0029 4.8 µM -1.59552219965368 0.0909355891070022 no 3066 0.0552977548714156 4520 4588309
SGTC_2450 5739737 12.93 µM -1.60219371089375 0.0899929542273708 no 3067 0.0545563901851016 4560 2262825
SGTC_670 4204-0025 119 µM -1.61206192412427 0.0886119904278455 no 3068 0.0534742326293537 4564 719039
SGTC_1649 st011737 51.3 µM -1.61862163602281 0.0877027934575134 no 3069 0.0527643484833992 4566 1761035
SGTC_3260 9137109 49.47 µM -1.62343928450613 0.087039497669764 no 3070 0.052247766303112 4544 17478346
SGTC_300 r073-0011 5.04 µM -1.62371355992921 0.0870018483563447 no 3071 0.052218477828878 4558 2735780
SGTC_1643 st009866 20.2 µM -1.62525998891598 0.086789800338306 no 3072 0.0520535864969816 4537 3156273 YOR207C RET1
SGTC_3356 9151811 4.48 µM -1.62694703656842 0.0865589112507138 no 3073 0.0518741734498076 4583 1859254 YPR165W RHO1
SGTC_3058 9093861 49.47 µM -1.63186625218365 0.085888289759446 no 3074 0.0513538323810268 4567 17217477
SGTC_1785 bathophenanthroline 24 µM -1.63577502717916 0.0853581968649448 no 3075 0.0509433401957158 4497 72812 An iron chelator.
SGTC_1030 k029-0042 36.7 µM -1.6384892298629 0.0849915515296083 no 3076 0.0506598394657939 4547 6080581
SGTC_329 k048-0121 21.3 µM -1.63936318887913 0.0848737452626847 no 3077 0.0505688216338319 4565 6832902
SGTC_608 k048-0125 159 µM -1.64152473942966 0.0845829025638572 no 3078 0.0503442679764826 4618 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1333 1482-0047 286 µM -1.64264978779571 0.0844318202703559 no 3079 0.0502277066465869 4594 3811116
SGTC_1376 2910-0861 41.3 µM -1.64503983704458 0.0841115336240578 no 3080 0.0499807980437315 4497 1112859
SGTC_2464 5717415 7.67 µM -1.6460941071587 0.0839705428391586 no 3081 0.0498721927460864 4540 5285744
SGTC_746 1095-0025 46.6 µM -1.64621063677583 0.0839549698731215 no 3082 0.0498602000462598 4581 6749286
SGTC_1558 st069300 45.6 µM -1.64991294997819 0.08346132271615 no 3083 0.0494803708369009 4530 24208000
SGTC_1026 k007-1105 30.6 µM -1.65239334287639 0.0831318224382483 no 3084 0.0492271958731215 4538 7066794
SGTC_179 1273-0063 6.77 µM -1.6530025427337 0.0830510449632343 no 3085 0.0491651730374018 4552 3108139
SGTC_184 1494-0393 24.714 µM -1.65522534329875 0.0827568110725098 no 3086 0.0489393981224206 4555 3090647
SGTC_1085 doxorubicin 7.67 µM -1.65588943524556 0.0826690570511613 no 3087 0.0488721057442828 4580 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2431 5490079 200 µM -1.65616927666187 0.0826320994022955 no 3088 0.0488437715903144 4587 5722345
SGTC_1350 1495-0454 146 µM -1.65791881479842 0.0824013260429114 no 3089 0.0486669270019894 4601 1069057
SGTC_3000 9075062 71.4286 µM -1.66326996097237 0.0816984934694799 no 3090 0.0481292044318315 4557 17057871
SGTC_1216 1165-0504 9.65 µM -1.66382270850303 0.0816261525632425 no 3091 0.0480739322557044 4608 6304004
SGTC_2661 dactinomycin 12.96 µM -1.66426664353999 0.0815680874848501 no 3092 0.0480295776133803 4570 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1720 st037298 9.481 µM -1.66828910025532 0.081043383739346 no 3093 0.047629175306272 4558 597396
SGTC_1534 6-azauridine 81.6 µM -1.67694189278231 0.0799233217323149 no 3094 0.0467769225386539 4620 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_971 1315-0384 26.7 µM -1.67959302546746 0.0795824989443952 no 3095 0.0465182628064607 4606 6769120
SGTC_2699 st077704 54.6 µM -1.68473843349137 0.0789241585930135 no 3096 0.0460195239302979 4572 645852
SGTC_1789 tunicamycin 25 nM -1.68937386786115 0.0783346077897603 no 3097 0.0455739028118987 4504 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3177 9107506 49.47 µM -1.69290729068288 0.0778874621628614 no 3098 0.0452365576845886 4565 8897194
SGTC_1058 3448-5425 97.3 µM -1.70185369823886 0.0767639800594361 no 3099 0.0443913986562264 4532 7279705
SGTC_2128 5255449 168.493 µM -1.70432466492917 0.0764558603717624 no 3100 0.0441602247436108 4515 736008
SGTC_3019 9081971 49.47 µM -1.70756318131279 0.0760534561099488 no 3101 0.0438587125179562 4573 16451803
SGTC_213 1246-0773 967 nM -1.71338296977355 0.0753343691729348 no 3102 0.0433210536382415 4617 6251622
SGTC_2767 sibutramine 71.45 µM -1.71560527691241 0.0750611547186968 no 3103 0.0431171560185997 4581 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1161 k007-0610 110 µM -1.7161849216836 0.0749900165478221 no 3104 0.0430641010271293 4530 5843850
SGTC_2681 menadione 3.18 µM -1.71928114515436 0.074610896429404 no 3105 0.042781595738427 4621 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3186 9110464 49.47 µM -1.72230289459084 0.0742423075683352 no 3106 0.0425073318192862 4592 17018021
SGTC_1450 4112-4260 37.6 µM -1.7245551386336 0.0739684876553963 no 3107 0.0423038370204373 4589 1633175
SGTC_2667 digitoxin 100 µM -1.73058862666659 0.0732387599264833 no 3108 0.0417625808167182 4580 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.7313592944652 0.0731459486130179 no 3109 0.0416938509737734 4590 442882
SGTC_751 0833-0568 350 µM -1.73213194966678 0.0730529883281211 no 3110 0.0416250358898816 4605 6954252
SGTC_3111 9122088 49.47 µM -1.73300599957564 0.0729479379855344 no 3111 0.0415473012182188 4556 16876704
SGTC_966 1300-0360 30.2 µM -1.7348148670206 0.0727309010714138 no 3112 0.0413868010079926 4590 70588
SGTC_79 0052-0007 94.094 µM -1.73485989494989 0.07272550471079 no 3113 0.0413828121138076 4594 2801472
SGTC_207 4185-0010 4.486 µM -1.73719670483171 0.0724458709512109 no 3114 0.0411762281827082 4643 3761753
SGTC_2916 7875993 68.79 µM -1.73833267475872 0.0723102332911836 no 3115 0.0410761060624926 4519 1299250
SGTC_712 r015-0009 80.6 µM -1.73857222915796 0.0722816547562687 no 3116 0.041055017442977 4637 6813872 YLR060W FRS1
SGTC_2141 5621638 7.665 µM -1.7388065468056 0.0722537093337758 no 3117 0.0410343983242107 4610 2856238
SGTC_2067 5224629 34.075 µM -1.73920139521078 0.0722066372668135 no 3118 0.0409996720708725 4575 2835000
SGTC_1015 4130-4525 82 µM -1.74257350652031 0.0718055862009994 no 3119 0.0407040705898877 4605 1363237
SGTC_1407 3909-7909 12.3 µM -1.74761724822448 0.0712089168839896 no 3120 0.0402651633096617 4632 4411780
SGTC_294 k038-0071 157 µM -1.75134058844323 0.0707708973917075 no 3121 0.0399436300895227 4634 24152826
SGTC_1800 st050079 29.0735 µM -1.75440056361063 0.0704124694561245 no 3122 0.0396809474192086 4436 3645560
SGTC_1310 1188-0297 994 nM -1.75745734784022 0.0700558104214481 no 3123 0.0394199428885288 4502 1588352
SGTC_2143 5623677 140.463 µM -1.76774462364374 0.0688657172520478 no 3124 0.0385518031501047 4597 5375313
SGTC_854 0422-0053 192 µM -1.76940717232394 0.0686748554146317 no 3125 0.0384129747815178 4631 3596728
SGTC_2046 4110841 106 µM -1.77272504298873 0.0682951810568385 no 3126 0.0381371396443571 4623 44119630 YMR134W ERG29
SGTC_3350 9150499 3.57 µM -1.77659658418673 0.067854198634034 no 3127 0.0378173190305799 4618 4910996 YPR165W RHO1
SGTC_2220 6782180 200 µM -1.77685201330072 0.0678251818516151 no 3128 0.0377962957213274 4582 833803
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.78034094364249 0.0674297977063929 no 3129 0.0375100901529059 4621 6710655
SGTC_898 1000-0849 28.3 µM -1.78098158464545 0.0673573908297415 no 3130 0.0374577296012218 4623 6751807
SGTC_1744 st037937 38.9 µM -1.78817304745663 0.06654871184948 no 3131 0.036874046642271 4635 1016152
SGTC_2784 7567673 72.73 µM -1.79028839546661 0.0663122773554405 no 3132 0.036703780422367 4548 3471247
SGTC_3093 9117344 49.47 µM -1.79181647546662 0.0661418874349361 no 3133 0.0365811843983198 4635 24824913
SGTC_922 1866-0035 480 µM -1.79183716422028 0.0661395828461972 no 3134 0.0365795268658346 4571 3156169
SGTC_1567 st069303 68.4 µM -1.79212172711603 0.0661078907548004 no 3135 0.0365567346148006 4615 5581319
SGTC_1757 st041620 31.8375 µM -1.79307580416665 0.0660017199530259 no 3136 0.0364804019606322 4614 5289815
SGTC_3133 9127736 49.47 µM -1.79927953590064 0.0653145810421173 no 3137 0.0359872367611308 4623 27243420
SGTC_941 3237-0776 460 µM -1.80543701434096 0.0646380658591828 no 3138 0.0355031617039241 4618 760008
SGTC_2449 5812982 45.77 µM -1.80568405726084 0.0646110375209759 no 3139 0.0354838521666228 4562 776185
SGTC_2816 7982706 58.44 µM -1.81040890406684 0.0640957917947745 no 3140 0.0351161997555603 4609 2981853
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.81236743486673 0.0638831523325521 no 3141 0.0349647205800107 4628 803109
SGTC_2309 7664088 163.95 µM -1.81534470581525 0.0635609587588296 no 3142 0.0347354763913467 4596 704922
SGTC_524 r073-0010 27.8 µM -1.8235494309919 0.062679604472038 no 3143 0.0341101087905324 4586 2772106
SGTC_1225 1216-0074 20.6 µM -1.8293708370478 0.0620600649596988 no 3144 0.0336720366695673 4627 4241466
SGTC_2645 abamectin 100 µM -1.82950122285994 0.062046243635999 no 3145 0.0336622781450203 4590 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2858 9025781 8.96 µM -1.83276377965746 0.0617011832626722 no 3146 0.0334188538836603 4451 4894980 YPL153C RAD53
SGTC_2055 5235184 200 µM -1.83295777910013 0.0616807124345174 no 3147 0.0334044250659246 4636 2836034
SGTC_2380 9035439 200 µM -1.83623581475948 0.0613356152168613 no 3148 0.0331613939558879 4662 6462575
SGTC_1859 st055998 20 µM -1.83767324289371 0.0611847656445 no 3149 0.0330552844666282 4576 676301
SGTC_1495 4469-0029 237 µM -1.83898386694952 0.0610474762403145 no 3150 0.0329587795090952 4651 793680
SGTC_384 k007-0144 5.16 µM -1.84423681568106 0.0604996389916248 no 3151 0.0325743175865929 4611 6824886
SGTC_1974 st069448 26.9 µM -1.84655993400194 0.0602585878645256 no 3152 0.0324054727624514 4631 6323587 YNR016C ACC1
SGTC_281 1672-3440 14.9 µM -1.848350483509 0.0600733106119401 no 3153 0.0322758285003871 4668 6833000
SGTC_2466 5983409 37.09 µM -1.85550403166802 0.059337544217343 no 3154 0.0317621420183641 4645 2879657
SGTC_2157 5649910 96.377 µM -1.85576798435372 0.0593105315654673 no 3155 0.031743317901813 4625 2858091
SGTC_474 dl-dihydrosphingosine 5 µM -1.85640531000128 0.0592453480475454 no 3156 0.0316979042194691 4617 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_628 1636-0253 16 µM -1.85658961832402 0.0592265080894329 no 3157 0.0316847810402151 4643 4456143
SGTC_3233 9132340 49.47 µM -1.85912137677038 0.0589681875301613 no 3158 0.0315049679407643 4661 17682950
SGTC_505 gw-5074 63.9 µM -1.86412037971397 0.0584607254452172 no 3159 0.0311524005980285 4635 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_877 0771-0151 33.1 µM -1.86423459482959 0.0584491713628459 no 3160 0.0311443835821667 4653 6166523
SGTC_488 nitrendipine 139 µM -1.87010354846197 0.0578578737113824 no 3161 0.0307347199129066 4659 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_3080 9117754 49.47 µM -1.87073289054834 0.0577947475997359 no 3162 0.0306910567707863 4639 9550191
SGTC_268 camptothecin 39.6153 µM -1.87268253375112 0.0575995324494739 no 3163 0.0305561183347198 4594 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2490 carminic acid 95.39 µM -1.87504056597 0.0573641191950501 no 3164 0.0303935714893775 4647 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1128 3448-9350 235 µM -1.87709564467684 0.0571595691691401 no 3165 0.0302524931169699 4600 619386
SGTC_3202 9113761 49.47 µM -1.88213291026063 0.0566606185012358 no 3166 0.0299089859762185 4583 4798415
SGTC_2084 5306078 60.6385 µM -1.88291145171586 0.0565838095681017 no 3167 0.0298561845136716 4608 679340
SGTC_2865 9030313 51.95 µM -1.88497541670337 0.056380581010673 no 3168 0.0297165784464761 4629 42562754
SGTC_1505 k297-0037 20.6 µM -1.88563969131986 0.0563152956532604 no 3169 0.0296717624620873 4640 4089396
SGTC_1818 st052136 56.3 µM -1.89208872080785 0.0556845741569646 no 3170 0.0292395804371192 4341 674169
SGTC_805 3852-0218 479 µM -1.89259330029837 0.0556354618847203 no 3171 0.0292059877084666 4647 6615355
SGTC_663 1486-0733 13.9 µM -1.89693702100117 0.0552140868954322 no 3172 0.0289181253163881 4668 722445 YPR165W RHO1
SGTC_2001 4023502 57.655 µM -1.90736478301067 0.0542128006975459 no 3173 0.0282366832390941 4629 108941 YCR052W RSC6
SGTC_2796 7949634 45.45 µM -1.90895522816175 0.0540613550984299 no 3174 0.028133933771997 4618 2971588
SGTC_362 0310-0100 9.03 µM -1.92334606957578 0.0527062048239218 no 3175 0.0272183012240236 4668 790235
SGTC_1497 4476-2978 41.3 µM -1.92687536255979 0.052378010172657 no 3176 0.0269975822947766 4699 1528379
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.93277075616907 0.0518334090051429 no 3177 0.02663222218388 4636 4000243
SGTC_586 0957-0265 8.15 µM -1.93473170662457 0.0516532621675995 no 3178 0.0265116137090308 4587 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_768 0384-0033 77.3 µM -1.94847635404833 0.0504045141535025 no 3179 0.0256789957429684 4641 3965305 YMR134W ERG29
SGTC_1860 st056228 74.6 µM -1.9511919588132 0.0501606616178485 no 3180 0.0255171075927561 4666 688679
SGTC_3235 9132602 49.47 µM -1.95168858067191 0.0501161684684568 no 3181 0.0254875945934331 4652 4912240
SGTC_845 0330-0138 4.51 µM -1.95440824342793 0.0498730672106555 no 3182 0.0253264782959063 4649 9039800
SGTC_1409 3909-8004 61.9 µM -1.96018684686628 0.0493596603505336 no 3183 0.0249869776401987 4705 2119279
SGTC_2489 cantharidin 73.42 µM -1.96120012490422 0.0492700708092188 no 3184 0.024927841156696 4632 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2692 st077426 47.7 µM -1.9634791668925 0.0490690424782808 no 3185 0.0247952614408044 4651 25238571
SGTC_3216 9129716 49.47 µM -1.96437693466833 0.0489900328366699 no 3186 0.024743197827601 4594 8056934
SGTC_1926 methyl fluorone black 53.6 µM -1.96549882895335 0.0488914414459692 no 3187 0.0246782655373406 4333 72721 Reacts with homocysteine.
SGTC_3345 9148410 3.559 µM -1.96892941222437 0.0485909471984213 no 3188 0.0244805987439226 4622 4903596
SGTC_2899 9053889 58.44 µM -1.97326698835532 0.0482131227435474 no 3189 0.0242325759514806 4687 6470052
SGTC_937 3122-0005 46.7 µM -1.97694111732993 0.0478949297472282 no 3190 0.0240241431991139 4646 759535
SGTC_1773 st048542 73.5835 µM -1.97889291433031 0.047726581992693 no 3191 0.02391403210153 4670 3237138
SGTC_1760 st045453 10.4495 µM -1.9799205268567 0.0476381382446647 no 3192 0.0238562297437132 4679 3323419 YIL048W NEO1
SGTC_566 0958-0068 16.5 µM -1.98077963352771 0.0475642981148283 no 3193 0.0238079958756451 4601 6815365
SGTC_1547 harmine 94.2 µM -1.98773686086523 0.0469696973020741 no 3194 0.0234203999772963 4605 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1682 st012968 530 nM -1.9915909664308 0.0466428799381312 no 3195 0.0232079776733184 4644 24207270
SGTC_1712 st032288 53.4 µM -1.99322236170257 0.0465050929756291 no 3196 0.0231185517543772 4479 2883011
SGTC_3162 9099653 49.47 µM -1.99630420259536 0.0462456935937136 no 3197 0.0229504104438876 4672 25237511
SGTC_846 0335-0850 148 µM -1.99676586496343 0.046206935600474 no 3198 0.0229253116638309 4676 6819598
SGTC_426 0988-0037 14.6 µM -2.00666068531379 0.0453824881318268 no 3199 0.0223929024367704 4668 5383008
SGTC_2439 5492030 7.2 µM -2.0161544235815 0.044602621628271 no 3200 0.021891915282563 4680 5722370
SGTC_3061 glucosamine 200 µM -2.01985366907881 0.0443016836443191 no 3201 0.0216992841343293 4634 91431 and experimental redox chemotherapeutic
SGTC_658 3253-0951 102 µM -2.04114457015188 0.042601318164372 no 3202 0.0206182296777002 4696 1184878
SGTC_1718 roemerine 11.9335 µM -2.0601486802795 0.0411285205436245 no 3203 0.0196921646434872 4324 235224 An aporphine alkaloid with mutagenic activity.
SGTC_881 0833-0569 170 µM -2.06028152641606 0.0411183723135311 no 3204 0.019685817467905 4700 5418700
SGTC_2473 5854593 8.94 µM -2.07407742622367 0.040075495626082 no 3205 0.0190360603411099 4691 2872951
SGTC_1408 3909-7976 48.8 µM -2.07526972728865 0.0399863838532249 no 3206 0.0189807717363826 4719 24152374
SGTC_1893 st059353 36.1 µM -2.0765546220709 0.0398905320275805 no 3207 0.0189213423913551 4695 3112488
SGTC_2104 5389443 200 µM -2.0791949759652 0.0396941505320868 no 3208 0.0187997166265992 4710 2244536
SGTC_2778 tioconazole 65.09 nM -2.0913535744909 0.0387999520162384 no 3209 0.0182481902933879 4597 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_887 0885-0007 9.62 µM -2.10292587924506 0.0379641795358394 no 3210 0.017736124606576 4711 5719458
SGTC_930 2810-3379 265 µM -2.10296618442117 0.0379612944984949 no 3211 0.017734362781299 4694 1015764
SGTC_1795 st049545 62.3 µM -2.10538998420354 0.0377881278924539 no 3212 0.0176286874642899 4690 5291882
SGTC_1146 3579-1023 7 µM -2.1074814365332 0.037639224269387 no 3213 0.0175379345677457 4717 X1146
SGTC_2476 5806916 10.51 µM -2.10865892153291 0.0375556027025222 no 3214 0.0174870165006878 4664 2870194
SGTC_3170 9103054 49.47 µM -2.10952369809453 0.037494285446492 no 3215 0.0174497013413381 4678 16432970
SGTC_2382 9035899 200 µM -2.11336485177696 0.0372229145580803 no 3216 0.017284775954887 4699 6462679
SGTC_1709 st033179 39.1045 µM -2.12158559786136 0.036647524387744 no 3217 0.0169362764320696 4718 573381
SGTC_1897 st060201 15 µM -2.12849144957121 0.0361698085617599 no 3218 0.0166481790674859 4708 611878
SGTC_2115 tiliquinol 12.7705 µM -2.12980411502348 0.0360795834832906 no 3219 0.0165938944105257 4677 71208 A bioactive hydroxyquinoline.
SGTC_490 phenamil 164 µM -2.13336606416123 0.0358356838856301 no 3220 0.0164473543227582 4729 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1556 plumbagin 1.48 µM -2.13748490192114 0.0355553380428458 no 3221 0.016279286216458 4664 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1100 amiodarone 5.07 µM -2.14280140108041 0.0351961349857185 no 3222 0.0160645243875113 4718 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1469 k284-2957 126 µM -2.15430708385351 0.0344289557667175 no 3223 0.0156080488582056 4735 23884841
SGTC_2196 6573537 42.6665 µM -2.15787344980214 0.0341939652316856 no 3224 0.015468836128067 4729 2903087
SGTC_2838 9002687 71.43 µM -2.182628888333 0.0325989120803665 no 3225 0.0145315752995145 4692 6457060
SGTC_2685 mycophenolic acid 18.85 µM -2.18592572089438 0.0323911955263419 no 3226 0.0144105200608218 4735 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2664 lyso-paf C-16 73.48 µM -2.1859501875298 0.0323896581007305 no 3227 0.014409624934593 4718 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_302 1094-0063 18.9 µM -2.1876003801409 0.0322861027894516 no 3228 0.014349362067035 4732 5440289
SGTC_769 0302-0231 76 µM -2.18929341014646 0.0321801434077127 no 3229 0.0142877605117589 4661 571869 YER009W NTF2
SGTC_765 1319-0117 244 µM -2.18959635286211 0.032161213851915 no 3230 0.0142767618812361 4705 3487746 YGL099W LSG1
SGTC_3328 9140624 29.0385 µM -2.19570405258236 0.0317815273181016 no 3231 0.0140565664594522 4710 4904392
SGTC_939 1165-0479 45.3 µM -2.19707133360853 0.0316970392388416 no 3232 0.0140076760275928 4703 1377347
SGTC_2592 piperlongumine 83.33 µM -2.19848962332919 0.0316095953814966 no 3233 0.0139571166077735 4704 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_875 0709-0210 25.7 µM -2.20768343396449 0.0310475790801565 no 3234 0.0136331742175627 4721 6251364
SGTC_419 nsc-638432 893 µM -2.20776967293117 0.0310423467042349 no 3235 0.0136301665787425 4714 368090
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -2.21757121266179 0.0304523943644271 no 3236 0.0132920412624029 4696 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1222 0366-0074 1.18 µM -2.22506362535311 0.0300077178950138 no 3237 0.0130384835961818 4739 286520
SGTC_2986 9022445 71.43 µM -2.22940108313177 0.0297527588020284 no 3238 0.0128936151182938 4718 6459286
SGTC_2127 5253358 187.912 µM -2.23028885979849 0.0297007968099789 no 3239 0.012864136137062 4688 20612
SGTC_2269 7935389 174.42 µM -2.23497280702986 0.0294278883855159 no 3240 0.0127095670210575 4723 97605
SGTC_2671 danthron 100 µM -2.23876390275898 0.0292085290573586 no 3241 0.0125856410707046 4721 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1299 1079-1439 3.74 µM -2.24028292072354 0.0291210180205693 no 3242 0.0125362806636567 4731 323161
SGTC_3316 9136639 10.545 µM -2.24036198658104 0.029116468985649 no 3243 0.0125337160181522 4743 4903665
SGTC_2007 4011539 71.82 µM -2.24329825462927 0.0289479491358809 no 3244 0.0124387939280609 4713 45595301
SGTC_2619 obliquin 87.91 µM -2.24813070909467 0.0286723676573297 no 3245 0.0122839282075139 4719 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3291 9121177 71.43 µM -2.25802617396008 0.0281148618779837 no 3246 0.0119720138349689 4705 17015612
SGTC_1734 st037168 69.4 µM -2.25819585578822 0.0281053813596496 no 3247 0.0119667257621229 4716 708907
SGTC_2820 7989630 71.43 µM -2.25830997633937 0.0280990066763144 no 3248 0.0119631703758681 4747 2984098
SGTC_1207 2099-0101 141 µM -2.27499875702664 0.0271796602048063 no 3249 0.0114530021981675 4743 5837381
SGTC_393 acivicin 6.25 µM -2.27619246116321 0.0271148748362007 no 3250 0.0114172464695186 4639 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_97 0535-0701 19.132 µM -2.27690078043998 0.027076493492972 no 3251 0.011396075640513 4669 2832013 YGL099W LSG1
SGTC_1046 2001-0062 216 µM -2.28479682723426 0.0266516958414464 no 3252 0.0111623718974616 4718 739778
SGTC_1754 st042065 16.137 µM -2.28640523933286 0.0265658512362164 no 3253 0.0111152810539167 4563 1126236 YIL048W NEO1
SGTC_2468 5987765 72.9 µM -2.29401772664424 0.0261626834308505 no 3254 0.0108947402689532 4747 26772094
SGTC_695 3505-6186 243 µM -2.29901545296688 0.0259007889668225 no 3255 0.0107520309190543 4722 1819379
SGTC_2493 resveratrol 26.09 µM -2.3277891876312 0.0244352862645695 no 3256 0.00996165024774649 4737 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_3337 9144342 33.5465 µM -2.32884108263362 0.0243830577861693 no 3257 0.00993374305201481 4733 17682949
SGTC_2905 7799065 20.05 µM -2.336257357769 0.0240174799437925 no 3258 0.00973891625991043 4685 1296806
SGTC_659 k018-0002 107 µM -2.33645163584102 0.0240079654451996 no 3259 0.00973385773055336 4733 6797879 YHR007C ERG11
SGTC_2919 7978188 46.38 µM -2.33912751884706 0.0238772397024232 no 3260 0.00966441742673539 4723 2980291
SGTC_3089 9117425 49.47 µM -2.34077293231628 0.0237971532576458 no 3261 0.00962193351642824 4726 9401657
SGTC_445 e6 berbamine 66 µM -2.34361486878496 0.0236593608723013 no 3262 0.00954894020618253 4742 6610268 A calcium/calmodulin antagonist.
SGTC_1456 k015-0012 13 µM -2.34605216306499 0.023541722768258 no 3263 0.0094867259437599 4735 2989616
SGTC_491 tetrandrine 80.3 µM -2.3548136475695 0.0231228977701659 no 3264 0.00926599839041716 4758 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3012 9080433 71.4286 µM -2.37265290032662 0.0222894994907872 no 3265 0.00883042586514421 4745 17688859
SGTC_2606 farnesol 9.78 µM -2.37925209484377 0.0219876934651423 no 3266 0.00867390369879382 4724 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1656 st012921 11 µM -2.38326929572652 0.0218056665764499 no 3267 0.00857981819355259 4700 6732821
SGTC_2675 theaflavin digallate 100 µM -2.38525891381089 0.0217159855811589 no 3268 0.00853355241513503 4709 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.4075118337361 0.0207340031373354 no 3269 0.00803082083014815 4713 279621
SGTC_2718 lomofungin 53.02 µM -2.41490528178268 0.0204161791662683 no 3270 0.00786965101453994 4730 5351222 A RNA synthesis inhibitor.
SGTC_3135 9127742 49.47 µM -2.42245794987711 0.0200957834991437 no 3271 0.00770795489237847 4764 3643468
SGTC_3073 9114972 49.47 µM -2.4253412557503 0.0199745991037809 no 3272 0.00764700139101511 4754 41905075
SGTC_577 r071-0003 38.6 µM -2.43667040081828 0.0195044254132254 no 3273 0.00741159179734651 4743 4568517 YMR134W ERG29
SGTC_3348 9149464 3.537 µM -2.45058764531471 0.0189397398445287 no 3274 0.00713116179525992 4742 1951442
SGTC_1430 4049-0248 69.1 µM -2.45732945984262 0.0186712320840752 no 3275 0.00699871260872663 4767 22774488
SGTC_809 3998-0021 90 µM -2.46563440131597 0.0183449295466485 no 3276 0.00683854267575367 4735 715485
SGTC_2389 9091542 195.52 µM -2.48155951817247 0.0177328050018316 no 3277 0.00654044314887209 4740 3626624 YOL127W RPL25
SGTC_1304 1165-0502 251 µM -2.49344837001772 0.0172872643710619 no 3278 0.00632544906672851 4764 767425
SGTC_360 0957-0399 1.01 µM -2.49939154002817 0.0170681493692135 no 3279 0.00622033871019317 4758 6752301 YPR165W RHO1
SGTC_2539 epi(13)torulosol 80 µM -2.50085123661409 0.0170146972885996 no 3280 0.00619476046149704 4724 6708597
SGTC_1428 4049-0204 61.7 µM -2.51551013010909 0.0164857968048503 no 3281 0.00594301307180998 4774 X1428
SGTC_1054 3429-0080 167 µM -2.52861835660292 0.0160248274916374 no 3282 0.00572562347707756 4748 1162877
SGTC_1815 st051655 58.2 µM -2.55605091482918 0.0150957719644124 no 3283 0.00529338135024783 4762 5984156
SGTC_2818 7996756 12.99 µM -2.56153894733076 0.0149155718384781 no 3284 0.0052104778096508 4760 2241621
SGTC_2044 5102272 200 µM -2.58534733859334 0.0141550778850782 no 3285 0.00486404710146065 4773 592666
SGTC_1203 3992-3522 103 µM -2.58712377220234 0.0140996984247583 no 3286 0.00483904104425506 4742 5322312
SGTC_794 k038-0031 316 µM -2.62045259926988 0.0130947745719392 no 3287 0.00439065683967094 4762 6624242
SGTC_3004 9076122 71.4286 µM -2.62277502577415 0.0130271160225692 no 3288 0.00436084215278188 4773 44782551
SGTC_1658 st012944 20 µM -2.62850999790133 0.0128613339784501 no 3289 0.00428799172436584 4670 24207260
SGTC_3142 9086498 49.47 µM -2.65708191268243 0.0120623192262611 no 3290 0.00394101444881866 4693 25236367
SGTC_3294 9122953 26.2835 µM -2.67485790221179 0.0115872355046457 no 3291 0.0037380465112215 4758 16459826
SGTC_2836 9010338 19.48 µM -2.71025349135109 0.0106894376390209 no 3292 0.00336159017073101 4742 2994051
SGTC_1676 st018489 23.4 µM -2.72493157577836 0.0103352824717196 no 3293 0.0032157407095881 4765 3696235
SGTC_2436 5633522 8.09 µM -2.75088981229176 0.00973395587718345 no 3294 0.00297168156432317 4766 5724242
SGTC_3150 9097574 49.47 µM -2.75882946399766 0.00955624326068527 no 3295 0.00290043991224287 4785 17217476
SGTC_2013 4024628 200 µM -2.81187376112759 0.00844010409475391 no 3296 0.00246269148907789 4769 5230760
SGTC_293 4049-0273 38.5 µM -2.82235592362831 0.00823361181385319 no 3297 0.00238361184594003 4747 1380311
SGTC_2666 tannic acid 100 µM -2.82266687861543 0.00822755456098936 no 3298 0.00238130143742346 4778 16134267 A thiamine antagonist.
SGTC_2593 nobiletin 86.24 µM -2.82366510966829 0.00820813594728969 no 3299 0.00237389822952286 4763 72344 An anti-infammatory.
SGTC_339 3091-4833 71.4 µM -2.82429687939105 0.00819586692977649 no 3300 0.00236922358922054 4675 3240077
SGTC_1587 estradiol valerate 56.1 µM -2.82811500652006 0.0081220609508748 no 3301 0.00234114910872984 4799 13791 A steroid.
SGTC_1265 0819-1001 68.8 µM -2.83998826676732 0.00789626498374636 no 3302 0.0022557596598436 4754 3106768
SGTC_2131 toluylene red 5.2905 µM -2.86530279885794 0.00743320748535729 no 3303 0.00208305332477846 4758 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1420 4'-methoxyflavone 42 µM -2.88150598974245 0.00714953081855535 no 3304 0.00197889856077557 4795 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3040 9091894 49.47 µM -2.89983426867896 0.00684019813119625 no 3305 0.00186680005855026 4766 25236966
SGTC_2636 apigenin dimethyl ether 100 µM -2.90501005111066 0.00675501287761408 no 3306 0.00183620653439689 4763 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1560 lithocholic acid 53.1 µM -2.91870595582943 0.00653410541921214 no 3307 0.00175743800498733 4779 9903 A bile acid which acts as a detergent.
SGTC_1784 st039334 36.3 µM -2.94418401480938 0.00614010140990673 no 3308 0.00161903705491328 4789 3496984
SGTC_642 0335-0876 158 µM -3.0219453175972 0.00506457022419084 no 3309 0.00125577957068521 4800 6812350
SGTC_1048 3161-0300 24.5 µM -3.0226581365089 0.00505554082644563 no 3310 0.00125282564454138 4789 2165101
SGTC_2586 curcumin 80 µM -3.02359585119897 0.00504368446873339 no 3311 0.001248949429825 4749 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3319 9138450 16.7555 µM -3.03725331431547 0.00487378592401465 no 3312 0.00119372364887188 4783 2029690
SGTC_2738 aclarubicin 5.55 µM -3.0459179023855 0.00476866128777862 no 3313 0.00115985582441734 4801 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_309 k408-0051 1.48 µM -3.07440233237192 0.00443717347966068 no 3314 0.00105462385490062 4754 3640463
SGTC_2564 betulinic acid 100 µM -3.21352032828428 0.00309597304495644 no 3315 0.000655592580495896 4766 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_367 0335-0881 7.1 µM -3.22752838192341 0.00298357162794889 no 3316 0.000624323266556872 4774 23828853
SGTC_649 1123-0311 367 µM -3.22795502806588 0.00298020664976385 no 3317 0.000623392867559453 4766 693629 YIL048W NEO1
SGTC_1731 st035964 63 µM -3.24834335911957 0.00282333552559998 no 3318 0.000580395510107948 4766 6739575
SGTC_801 0866-0028 10.1 µM -3.26961747694396 0.0026676268042947 no 3319 0.000538465043435223 4797 6849771
SGTC_304 1310-0298 97 µM -3.29052422011445 0.00252220525564236 no 3320 0.000500004463214186 4692 1550234
SGTC_3333 9141820 12.094 µM -3.30231704907218 0.00244337616097998 no 3321 0.000479448089528848 4784 1939433
SGTC_910 3454-3003 490 µM -3.33011852978711 0.00226628482463253 no 3322 0.000434045109379145 4766 820824
SGTC_1470 k295-0292 231 µM -3.33134135799172 0.00225876951712453 no 3323 0.000432142735014732 4807 5045612
SGTC_2795 7780010 54.55 µM -3.36013924806557 0.00208818330486048 no 3324 0.000389515984890637 4786 953673
SGTC_3083 9117465 49.47 µM -3.40557029414947 0.00184271798429681 no 3325 0.000330130066030596 4790 16420915
SGTC_1679 SEC14.276 6.7 µM -3.44719874648067 0.00164114598827799 no 3326 0.000283215861794478 4784 1005053 YMR079W SEC14
SGTC_1047 2043-3044 82 µM -3.47789307993614 0.00150561710621279 no 3327 0.000252685732599933 4787 669592
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -3.51111313354462 0.00137050331649068 no 3328 0.000223117222981658 4786 5377381
SGTC_1501 4491-0275 38.4 µM -3.51175217745285 0.00136801636239004 no 3329 0.00022258145003866 4808 5104718
SGTC_1489 4065-0444 182 µM -3.57278661078061 0.00114863723621432 no 3330 0.000176601285241142 4808 2877968
SGTC_1305 1181-0477 144 µM -3.59841788630325 0.00106651771255606 no 3331 0.000160079450373476 4807 6252086
SGTC_2741 miltefosine 3.04 µM -3.6039545058547 0.00104950163040903 no 3332 0.000156705969375153 4807 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_955 1216-0110 33 µM -3.61151430105946 0.00102666957104591 no 3333 0.000152207146875271 4788 3619719
SGTC_431 k089-0097 107 µM -3.65259317505714 0.000910374862153394 yes 3334 0.000129802675723902 4680 5499420
SGTC_1311 1190-0148 100 µM -3.65263482568619 0.000910263355095404 yes 3335 0.000129781616499023 4808 1961333
SGTC_3330 9141424 71.43 µM -3.66725314300707 0.000871893382653798 yes 3336 0.000122585025240767 4802 27261020
SGTC_3283 9109332 35.8195 µM -3.69222373036055 0.000809773861615736 yes 3337 0.000111150884679325 4779 17027281
SGTC_2896 9052656 71.43 µM -3.73263091025273 0.000717823771651755 yes 3338 9.47450788853005e-05 4598 6469436
SGTC_2175 5807670 165.306 µM -3.79663571440986 0.000591674053551924 yes 3339 7.33365400469948e-05 4806 241186
SGTC_951 1171-0579 82.7 µM -3.85060119009749 0.000501579849106116 yes 3340 5.89141171502715e-05 4779 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_151 3013-0144 2.285 µM -3.90808220451259 0.000419704783660082 yes 3341 4.65158274829951e-05 4738 906558 YHR107C CDC12
SGTC_1707 st032323 6.317 µM -3.95174937732583 0.000365991496915512 yes 3342 3.87909841576357e-05 4773 3132057 YMR211W DML1
SGTC_1962 st076595 64.5 µM -4.09812320848105 0.000229005711251502 yes 3343 2.08256785326669e-05 4802 279619
SGTC_2851 9015922 71.43 µM -4.32729415624592 0.000106608169137633 yes 3344 7.54761531985424e-06 4805 2996893
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -4.39376683866436 8.48087403191079e-05 yes 3345 5.57016491162445e-06 4802 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3326 9140064 16.379 µM -4.54445394485742 4.9906447054732e-05 yes 3346 2.75389237798984e-06 4809 1868434
SGTC_2179 6298986 200 µM -4.73143437210601 2.52701424700561e-05 yes 3347 1.11469447762842e-06 4804 738374
SGTC_1968 st069590 43.6 µM -4.75810610617264 2.28856310285388e-05 yes 3348 9.77088877332787e-07 4807 6384066
SGTC_2021 4019055 173 µM -4.88815808501291 1.40119774620737e-05 yes 3349 5.08918926088148e-07 4791 44827708 YER133W GLC7
SGTC_1787 fluconazole 80 µM -5.05418003412065 7.35927079964698e-06 yes 3350 2.16121866999832e-07 4733 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2184 6075246 200 µM -5.60244693311223 7.61943679402104e-07 yes 3351 1.05673376144541e-08 4806 2267320