SGTCid condition conc unit GPM1|YKL152C.score GPM1|YKL152C.strain.pval GPM1|YKL152C.strain.significant GPM1|YKL152C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2936 9038235 15.59 µM 5.42451795803926 4.26835066245501e-10 yes 1 2.9055574002107e-08 2 4749415
SGTC_899 1083-0020 478 µM 5.1457795125032 2.95025886935146e-09 yes 2 1.33206095766051e-07 2 767123
SGTC_2565 isoliquiritigenin 100 µM 4.46115220401633 2.25913586267929e-07 yes 3 4.07600820282387e-06 7 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2807 7945238 51.95 µM 4.39661526021188 3.30016222464017e-07 yes 4 5.49759930768475e-06 2 17148797
SGTC_3202 9113761 49.47 µM 4.36371855274916 3.99552634042254e-07 yes 5 6.39350341295267e-06 7 4798415
SGTC_690 glyoxal 20.3 µM 4.28974733061366 6.11187696658446e-07 yes 6 8.94382538817703e-06 24 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_101 0490-5701 117.494 µM 3.76820513292234 1.01087947383997e-05 yes 7 8.22127804781613e-05 6 4661669
SGTC_390 dec-rvkr-cmk 16.7 µM 3.72251443390277 1.27217232697803e-05 yes 8 9.86243145312663e-05 10 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1743 st037606 46.3785 µM 3.69475098428382 1.46108396862464e-05 yes 9 0.000110051193946626 10 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_3033 9090887 49.47 µM 3.56894049512685 2.7041362808612e-05 yes 10 0.000179213907593464 23 19325384
SGTC_90 0870-0863 4.608 µM 3.45044696107444 4.74429124450003e-05 yes 11 0.00027982956312693 7 1738164
SGTC_1837 st055472 66.5 µM 3.3946205747097 6.14646242403202e-05 yes 12 0.000343618854476472 4 676091
SGTC_898 1000-0849 28.3 µM 3.38919670945638 6.30177906085904e-05 yes 13 0.000350488525450641 6 6751807
SGTC_372 0155-0182 15.9 µM 3.24162278825571 0.000122574268813854 yes 14 0.000594256109054337 13 771486
SGTC_99 0109-0120 622.8 µM 3.21356674062696 0.000138686718931544 yes 15 0.000655486632205073 11 759414
SGTC_100 0086-0128 49.5915 µM 3.14743902232117 0.000184849776304111 yes 16 0.000823537280307426 19 93297
SGTC_1788 fluconazole 20 µM 3.14528150561862 0.000186574193515503 yes 17 0.000829635426987653 17 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2877 9040724 71.43 µM 3.09880640254442 0.000227576216253515 yes 18 0.000971509702049399 6 6463895
SGTC_2409 alverine citrate 63.97 µM 3.08009129572658 0.000246348449158317 yes 19 0.00103468575969025 23 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1360 1598-0022 39.8 µM 3.07056916592666 0.000256444680263656 yes 20 0.00106825597504341 27 761525
SGTC_2815 7968870 71.43 µM 3.05809039052641 0.000270260228582522 yes 21 0.00111376187199258 12 2977326 YHR190W ERG9
SGTC_1975 st070967 30.8 µM 2.98093991671547 0.000372277105337221 yes 22 0.00143682583726643 29 261391
SGTC_733 4069-0007 56.1 µM 2.97394411437988 0.000383110894808131 yes 23 0.00146999307619029 30 5717425 YNL287W SEC21
SGTC_2315 7733312 200 µM 2.95937196059693 0.000406623770442911 yes 24 0.00154133386544297 20 726316
SGTC_2686 alizarin 95.37 µM 2.95306490283519 0.000417209927454527 yes 25 0.00157317901725859 18 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_106 0092-0003 11.579 µM 2.94807535587732 0.000425765201928544 yes 26 0.0015987955463478 13 1072148
SGTC_1289 0976-0073 69.1 µM 2.94509592219487 0.000430951146316384 yes 27 0.00161427276790715 12 3391136
SGTC_1569 carminic acid 40.6 µM 2.92371589026941 0.000469918185674849 yes 28 0.00172940140427014 9 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_173 1273-0061 2.693 µM 2.91951278676757 0.00047795268799205 yes 29 0.00175289505734373 45 2847414 YPL266W DIM1
SGTC_843 0310-0051 143 µM 2.8999857833095 0.000516975718405081 yes 30 0.00186589792743967 10 2065037
SGTC_3270 9137563 49.47 µM 2.85225636569238 0.000625099569925553 yes 31 0.00217050374783886 10 17015724
SGTC_1571 st070080 73.4 µM 2.85099485332131 0.000628221946504798 yes 32 0.00217913374525737 9 4315245
SGTC_542 3381-0244 89.3 µM 2.85069627231433 0.000628963070550462 yes 33 0.00218118088292527 20 1112843
SGTC_2243 6634756 200 µM 2.83652612624463 0.000665077996721343 yes 34 0.00228036233932053 10 885676
SGTC_3072 9116419 49.47 µM 2.80459903652965 0.000753569129608151 yes 35 0.00251896039279675 14 17170162
SGTC_3104 9120930 49.47 µM 2.80239333026157 0.000760066354290516 yes 36 0.00253624939298052 21 17014836
SGTC_1115 galangin 695.678 nM 2.79722241175617 0.000775500828025873 yes 37 0.00257720188407671 11 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3035 9091303 49.47 µM 2.78799667527927 0.000803757226083358 yes 38 0.00265175440433208 8 25237002
SGTC_2456 5770359 74.46 µM 2.76574718985368 0.000875844914495452 yes 39 0.00283962721230819 18 3118787
SGTC_554 4483-2211 187 µM 2.73543437693639 0.000983638592874209 yes 40 0.0031149003301396 14 747107
SGTC_2468 5987765 72.9 µM 2.710193932475 0.00108254550662828 no 41 0.00336219389995929 15 26772094
SGTC_1446 4239-0190 62 µM 2.70327982477315 0.00111118680885441 no 42 0.00343294591383647 27 1340085
SGTC_670 4204-0025 119 µM 2.68462251921849 0.00119197354574726 no 43 0.00363058821333665 12 719039
SGTC_2032 5185112 25.99 µM 2.68180977951201 0.00120460887871257 no 44 0.0036612541759614 6 5718189
SGTC_695 3505-6186 243 µM 2.66767279791233 0.00126999128019413 no 45 0.00381893007970308 35 1819379
SGTC_2043 5101342 149 µM 2.66165446978434 0.00129879795150968 no 46 0.0038878826797539 23 678451
SGTC_666 0272-0154 136 µM 2.65111175802754 0.00135070427546704 no 47 0.00401136450265386 41 6870312
SGTC_769 0302-0231 76 µM 2.64396391100945 0.00138696707983803 no 48 0.00409706961186072 52 571869 YER009W NTF2
SGTC_2453 5731132 22.18 µM 2.62651315844933 0.00147926493572456 no 49 0.00431323285511429 24 1362040
SGTC_892 0929-0076 29 µM 2.56270750415982 0.00186644212966998 no 50 0.00519297521985271 27 5751038
SGTC_1783 st039459 87.517 µM 2.54324013582214 0.00200172155088859 no 51 0.0054914859422959 28 729761
SGTC_2490 carminic acid 95.39 µM 2.52097472550526 0.00216731517040524 no 52 0.00585151288510719 32 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2997 9067075 71.4286 µM 2.49675426821399 0.00236147103443531 no 53 0.00626678883380297 50 27209819
SGTC_2207 7258803 200 µM 2.49550515301668 0.00237189847911987 no 54 0.00628889641915537 14 3666799
SGTC_2045 5106652 78.05 µM 2.47834290105563 0.00251944786224192 no 55 0.00659971118776086 15 673349
SGTC_526 4469-0568 170 µM 2.41538248912911 0.00313447230020112 no 56 0.00785934680398039 35 2901964
SGTC_1011 4112-3381 17.4 µM 2.3863484394219 0.00346119580737658 no 57 0.0085083098978055 28 2877139
SGTC_2750 bromebric acid 70.15 µM 2.354553696882 0.00385380103877638 no 58 0.00927248205473078 45 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_368 fentichlor 4.58 µM 2.35121651431911 0.00389724040679815 no 59 0.0093560710267331 34 7329 A pesticide.
SGTC_1060 3448-7350 82 µM 2.34649245035428 0.00395948258242485 no 60 0.00947552506676216 46 570178
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.3400022067949 0.00404644679246054 no 61 0.00964181297361831 38 5355888
SGTC_2015 5119600 184 µM 2.32770876420373 0.00421586864354276 no 62 0.00996378672716075 49 2828786
SGTC_1548 st061468 90.8 µM 2.3275898407634 0.00421753811250643 no 63 0.00996694670735281 13 390799
SGTC_2935 9038016 29.96 µM 2.318475314113 0.00434726210250261 no 64 0.0102117515327034 35 6463195
SGTC_1966 st070145 16.1 µM 2.28829502351599 0.00480263666945541 no 65 0.0110601730648726 40 3748532
SGTC_413 propylparaben 100 µM 2.28686371490461 0.00482525253205206 no 66 0.0111018895576371 29 7175 A pharmaceutical preservative.
SGTC_679 0422-0091 41.4 µM 2.28071290252287 0.00492352479838002 no 67 0.0112827205840227 50 627384 YHR062C RPP1
SGTC_3058 9093861 49.47 µM 2.27697076263416 0.00498418229166033 no 68 0.0113939858077301 40 17217477
SGTC_2303 7774051 200 µM 2.24733816622365 0.00548848839135972 no 69 0.0123092117356514 50 2953184
SGTC_1077 5-fluorocytosine 377 nM 2.22575685908437 0.0058838071669608 no 70 0.0130152359615703 53 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3151 9099821 49.47 µM 2.22218779033705 0.00595156341221418 no 71 0.0131353086259858 42 17174189
SGTC_1203 3992-3522 103 µM 2.21645687393084 0.00606180877589001 no 72 0.0133301141522704 53 5322312
SGTC_3128 9127691 49.47 µM 2.21071142945082 0.00617414656200138 no 73 0.0135279132757823 31 41316314
SGTC_890 0929-0006 47.2 µM 2.1878242392184 0.00664016489406014 no 74 0.0143412037684922 26 1378169
SGTC_2014 4013930 200 µM 2.17913353233802 0.00682510638789192 no 75 0.0146608749341423 46 64556
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.17350419420347 0.00694731533191079 no 76 0.0148711952446315 35 5377381
SGTC_3273 9137859 49.47 µM 2.17343428257409 0.00694884513197411 no 77 0.0148738234709357 39 2377234
SGTC_460 trequinsin 123 µM 2.16216719707905 0.00719931046989117 no 78 0.0153026454976268 22 5537 A vasodilator.
SGTC_926 2268-1401 59.4 µM 2.15347837942846 0.00739786531703363 no 79 0.0156405507458434 49 2931578
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 2.12932051150817 0.00797549572479331 no 80 0.0166138759548942 43 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1321 1326-2144 215 µM 2.11285895646661 0.00839147862529425 no 81 0.0173064208642927 40 3513030
SGTC_2052 5265182 7.135 µM 2.10610962000656 0.00856746549607791 no 82 0.0175974156971786 45 1239884
SGTC_2223 6903751 107.57 µM 2.10030570213805 0.00872138182195511 no 83 0.0178509789987278 42 5598863
SGTC_748 act1.228 77.9 µM 2.09845604237392 0.00877094050855278 no 84 0.0179324395540253 42 4421505 YNR035C ARC35
SGTC_2831 7999036 19.48 µM 2.09501208876246 0.00886387384469593 no 85 0.0180849589341051 51 2988270
SGTC_1624 st003710 6.25 µM 2.09430603182083 0.00888303266962847 no 86 0.0181163636834922 37 24207033
SGTC_1742 st038235 28.8875 µM 2.09211026183113 0.00894284689238674 no 87 0.0182143267004747 59 564103 YBR002C RER2
SGTC_1557 sumaresinolic acid 42.3 µM 2.0749880935901 0.00942149286443842 no 88 0.0189938191348863 31 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2030 5175110 200 µM 2.073309200195 0.00946961071229116 no 89 0.0190717565170793 37 2831986
SGTC_3277 9138724 49.47 µM 2.07139186512145 0.00952482513021532 no 90 0.0191610952492441 44 15943418
SGTC_3101 9120531 49.47 µM 2.05732947784137 0.00993845860801244 no 91 0.0198272718441054 54 24824904
SGTC_76 0433-0009 400.328 µM 2.05696586463083 0.00994935881730217 no 92 0.0198447547554323 37 2841569
SGTC_693 4161-2696 114 µM 2.0560966555066 0.00997545782403228 no 93 0.0198866002821282 42 805759
SGTC_2937 9044753 11.33 µM 2.05522526306827 0.0100016823556777 no 94 0.0199286260526983 48 6465530 YGL099W LSG1
SGTC_1843 st055809 45.5 µM 2.04533733805221 0.0103035005838505 no 95 0.0204108060141328 52 16413835
SGTC_589 1227-0070 34.1 µM 2.02389667734275 0.0109853538243437 no 96 0.021490391945577 50 2841384
SGTC_2963 9082507 9 µM 2.01161536171756 0.0113933434777608 no 97 0.0221302493993846 59 16459611
SGTC_3068 9116768 49.47 µM 2.00655649322609 0.0115651916913725 no 98 0.022398453883943 47 41904888
SGTC_809 3998-0021 90 µM 1.97795330707372 0.0125797835512272 no 99 0.0239669872101431 68 715485
SGTC_534 k292-0788 63.4 µM 1.97509895631184 0.012685137518602 no 100 0.0241284596329102 68 4146317
SGTC_1942 st076330 65.2 µM 1.97452989869941 0.0127062324526116 no 101 0.0241607606001559 45 24208414
SGTC_2916 7875993 68.79 µM 1.97173744473155 0.0128101890828402 no 102 0.0243197933588008 61 1299250
SGTC_2580 diallyl disulphide 81.36 µM 1.97143698204725 0.0128214183356878 no 103 0.024336957235359 59 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1600 coumarin 106 71.1 µM 1.96974631890852 0.0128847627102545 no 104 0.0244337258008082 43 100336 A hepatotoxic, DNA x-linker.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.96280180399982 0.0131478013375276 no 105 0.024834604060363 42 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_995 3931-2021 34.6 µM 1.95764315476031 0.0133461883885964 no 106 0.0251359499027352 52 730143
SGTC_1035 k081-0041 55.2 µM 1.94411986363485 0.0138785710724702 no 107 0.0259404992170174 53 731709
SGTC_2387 9077560 195.08 µM 1.94159992937603 0.0139797739435365 no 108 0.0260927757257492 56 5303272
SGTC_3276 9139060 49.47 µM 1.93639077054988 0.0141909968656085 no 109 0.0264099295072606 65 4870619
SGTC_807 1315-0151 48 µM 1.93359268361474 0.0143055856715397 no 110 0.0265816137677908 79 4011080
SGTC_2797 7859098 81.82 µM 1.92082672153117 0.014838550634071 no 111 0.0273767782375865 56 972681
SGTC_3320 9137005 35.139 µM 1.91597407767233 0.0150455761244122 no 112 0.0276841976596789 65 4908713
SGTC_958 1222-0007 33 µM 1.91082071960158 0.0152681439217877 no 113 0.0280138120452376 67 7312461
SGTC_543 3844-1095 191 µM 1.9093045561581 0.0153341613409479 no 114 0.0281114074541866 66 4230703
SGTC_1727 st034309 9.9045 µM 1.907668851222 0.0154056586204372 no 115 0.0282170150349543 77 870305
SGTC_349 k015-0014 24 µM 1.9042632705015 0.0155554365820731 no 116 0.0284379526064847 58 2196908
SGTC_1901 st060216 58.6 µM 1.90268356328981 0.0156253355653985 no 117 0.0285409239792143 59 688792
SGTC_2648 atorvastatin 78.68 µM 1.90152519322409 0.0156767623122597 no 118 0.0286166279232925 44 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_314 1671-0008 2.74 µM 1.88659526061926 0.0163526935999774 no 119 0.0296073923591372 74 3913060
SGTC_817 1391-0715 46 µM 1.88532206424564 0.0164114737257414 no 120 0.0296931845038166 80 1353946
SGTC_2305 7443522 69.23 µM 1.88327316503425 0.0165064458106513 no 121 0.0298316790740161 60 5415886
SGTC_109 0132-0036 33.701 µM 1.8683126911721 0.0172142672704725 no 122 0.0308592493361857 54 67274 A color developer.
SGTC_886 0866-0150 153 µM 1.8440522168705 0.01841719868409 no 123 0.032587765337193 57 271463
SGTC_2729 fluphenazine 10.66 µM 1.84062190783474 0.0185929334160385 no 124 0.032838492500461 70 3372 An atypical antipsychotic.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.83815968436307 0.0187199514570694 no 125 0.0330194392686181 70 1377
SGTC_1121 fusaric acid 630.51 nM 1.83276431744187 0.0190008647939573 no 126 0.0334188138785501 50 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1604 st002052 72.4 µM 1.82537123547363 0.0193916063502618 no 127 0.0339725134864758 49 6254834 YHR062C RPP1
SGTC_509 pifithrin 175 µM 1.82019676258116 0.019669132738115 no 128 0.0343645229812087 58 4817 A p53 inhibitor.
SGTC_881 0833-0569 170 µM 1.81970861799158 0.019695486975354 no 129 0.0344016951096272 65 5418700
SGTC_768 0384-0033 77.3 µM 1.81280324179101 0.0200715217063559 no 130 0.0349310868984734 76 3965305 YMR134W ERG29
SGTC_373 0844-0104 25.9 µM 1.80994106673957 0.0202291581616776 no 131 0.0351524633885426 84 5375804
SGTC_620 0109-0052 432 µM 1.80190265948058 0.0206775036873423 no 132 0.0357803608703946 63 493037
SGTC_1230 0170-0365 3.77 µM 1.79529241537565 0.0210524720818289 no 133 0.0363035614180094 86 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2283 7944793 200 µM 1.79371799729235 0.0211426250592576 no 134 0.0364290956191386 62 2970533
SGTC_246 cycloheximide 667 µM 1.79337427752199 0.0211623502199888 no 135 0.0364565488622891 68 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2779 methotrexate 400 µM 1.79006612802648 0.0213529932853785 no 136 0.0367216406353258 78 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_285 1486-1325 46 µM 1.78671747784629 0.0215474472515198 no 137 0.0369915813840781 75 22310230
SGTC_1987 st072290 61.9 µM 1.78167934106293 0.0218428270977657 no 138 0.0374007688490832 61 54697379
SGTC_2444 5485484 36.41 µM 1.77946803646714 0.0219735490406942 no 139 0.0375815303546558 85 6790631
SGTC_3246 9135460 32.98 µM 1.76993251050898 0.0225448343724801 no 140 0.03836919211337 62 41446951
SGTC_1006 4099-6547 255 µM 1.76537678477694 0.0228221640223461 no 141 0.038750231196743 70 3146833
SGTC_1243 0416-0003 5.65 µM 1.76029279172316 0.0231350402101466 no 142 0.0391790878653356 71 2141977
SGTC_811 0416-0114 265 µM 1.739395208143 0.024459295485006 no 143 0.0409826352726535 68 6612453
SGTC_749 1000-0129 128 µM 1.73249868169159 0.0249100508919033 no 144 0.0415924058052175 69 708470
SGTC_2513 baicalein 25.65 µM 1.73030928200763 0.0250545982050372 no 145 0.041787516031128 74 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1984 st072354 53.1 µM 1.72420975148914 0.0254610104734446 no 146 0.0423349921845602 66 5762938
SGTC_1476 4112-3294 3.34 µM 1.71899727365913 0.025812679931932 no 147 0.0428074341787189 56 704369
SGTC_823 0417-1665 178 µM 1.71407454444501 0.0261485241533756 no 148 0.043257518093503 74 3429856
SGTC_2273 7815444 169.05 µM 1.71323909888937 0.0262058820178296 no 149 0.0433342806406616 83 2824616
SGTC_2103 5378138 10 µM 1.71169917089347 0.0263118820814963 no 150 0.0434760607493711 57 244142
SGTC_2083 5306046 65.942 µM 1.70749572832695 0.0266030494280882 no 151 0.0438649755467236 63 539837
SGTC_2999 9069765 71.4286 µM 1.69758038865964 0.0273005490452498 no 152 0.04479349341265 58 2097066
SGTC_1152 3909-8331 15.9 µM 1.69335093146775 0.0276026793790573 no 153 0.0451943444587424 63 16001939
SGTC_224 benfluorex 43.875 µM 1.69137387767323 0.0277448627875529 no 154 0.0453827090781002 55 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_381 3461-2219 42.7 µM 1.68291785436033 0.0283598978751613 no 155 0.0461954973649978 74 2883159
SGTC_1259 0671-0132 43 µM 1.68115532533794 0.0284895111799886 no 156 0.0463663742215454 80 X1259
SGTC_1725 st036284 20.55 µM 1.67919734912833 0.0286340747633883 no 157 0.0465567942233925 65 707914
SGTC_2117 5521686 200 µM 1.67505123245418 0.028942209999787 no 158 0.0469620900578035 73 803312
SGTC_1085 doxorubicin 7.67 µM 1.6735718672962 0.0290528199066137 no 159 0.0471073856705458 95 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2196 6573537 42.6665 µM 1.66831324838051 0.0294488460483676 no 160 0.0476267796581531 75 2903087
SGTC_1240 0356-0016 42.1 µM 1.65689683699029 0.0303240549150606 no 161 0.048770166988947 73 4305613
SGTC_2158 5657123 3.6195 µM 1.64855641898799 0.0309769866534647 no 162 0.049619271643108 86 2858827
SGTC_2683 piperine 63.03 µM 1.63764937901124 0.0318483602482608 no 163 0.0507474280184286 80 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_134 0269-0018 6.916 µM 1.63709661255474 0.0318930549737861 no 164 0.0508051421417917 97 4378915
SGTC_1352 1496-0991 99 µM 1.62877627981009 0.0325720887168089 no 165 0.0516801939390372 81 3000039
SGTC_120 rhodamine 6G 52.259 µM 1.62636506965758 0.0327710847104687 no 166 0.0519360084854956 142 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1545 lovastatin 49.4 µM 1.6253740303837 0.0328531648326759 no 167 0.0520414429743494 102 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2855 9016525 58.44 µM 1.62252599091107 0.0330899896502018 no 168 0.052345386323874 95 43811474
SGTC_1127 asiatic acid 681.4 nM 1.61753464396687 0.0335084301505341 no 169 0.0528814618828818 80 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.61220929710866 0.0339596639134714 no 170 0.0534582014179187 92 688664
SGTC_463 ikarugamyin 104 µM 1.60896227077389 0.0342372391703904 no 171 0.0538122958963961 33 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_3107 9121808 49.47 µM 1.60711443649951 0.0343960339828154 no 172 0.0540146334962646 60 662681
SGTC_479 n-linoleoylglycine 10 µM 1.60692642601672 0.0344122246492337 no 173 0.054035254328878 87 6433346 An anti-infammatory.
SGTC_3315 9136395 68.55 µM 1.60627367530172 0.0344684853962427 no 174 0.0541068958590689 112 16876844
SGTC_3039 9090270 49.47 µM 1.60590041453375 0.034500690782991 no 175 0.0541478962238294 71 17173750
SGTC_2473 5854593 8.94 µM 1.6045131892851 0.0346205989769138 no 176 0.0543004897907979 84 2872951
SGTC_425 3825-7017 13.1 µM 1.600755484648 0.0349471256017777 no 177 0.0547155433464568 103 3397440
SGTC_3255 9139072 49.47 µM 1.59830113921293 0.03516175808153 no 178 0.0549879870028197 76 17646060
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.59314657018004 0.0356160465358683 no 179 0.0555636570487583 97 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_508 roscovitine 141 µM 1.59135442582755 0.0357751166413685 no 180 0.0557649173280446 87 160355 A CDKinase inhibitor.
SGTC_211 3455-0679 143.504 µM 1.58912538478111 0.0359737774072135 no 181 0.0560160438925358 63 748649
SGTC_1441 4106-0040 13 µM 1.58290866008489 0.0365326145198519 no 182 0.056721142301529 83 2904180
SGTC_2193 5925765 200 µM 1.58251444752581 0.0365682894511645 no 183 0.0567660883927677 71 877370
SGTC_2876 9059903 25.97 µM 1.58230854923196 0.0365869338929299 no 184 0.0567895750086512 91 6916095
SGTC_469 w7 172 µM 1.58195667866736 0.036618814373793 no 185 0.0568297302535417 61 45115570 A P450 inhibitor.
SGTC_2458 5808907 16.39 µM 1.58146424080549 0.0366634688068433 no 186 0.0568859644908748 100 2731747
SGTC_129 0088-0017 176.636 µM 1.57823689401981 0.0369572294217041 no 187 0.057255598687348 67 182446
SGTC_1673 st016611 27.3 µM 1.57764247910918 0.0370115437229146 no 188 0.0573238838318828 101 5226799
SGTC_2040 5100729 123 µM 1.57742839751901 0.0370311212726284 no 189 0.0573484927682746 91 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2572 astragaloside iv 100 µM 1.57020096624496 0.0376970449738269 no 190 0.0581841824245924 96 45006101 An anti-inflammatory agent.
SGTC_214 4373-3496 70 µM 1.56982240382563 0.0377321927891195 no 191 0.0582282169547131 131 3779166
SGTC_2820 7989630 71.43 µM 1.56892782629693 0.0378153565819963 no 192 0.0583323785986925 55 2984098
SGTC_2968 9090663 33.37 µM 1.5677010375511 0.0379296473397463 no 193 0.0584754597181324 134 25236811
SGTC_2741 miltefosine 3.04 µM 1.56487734576592 0.0381937807619365 no 194 0.058805835746311 53 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_343 4130-2827 29.8 µM 1.56373022318118 0.0383015123530044 no 195 0.0589404684512881 80 1118244
SGTC_714 4296-0578 26.1 µM 1.56131871718258 0.038528795972884 no 196 0.0592242847470955 73 1589775
SGTC_1547 harmine 94.2 µM 1.55499650640267 0.0391298839378423 no 197 0.0599734506858962 102 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_75 0159-0059 199.013 µM 1.5516332866814 0.0394527414263712 no 198 0.0603749968850857 106 5377270
SGTC_2242 6630449 61.2675 µM 1.5414827792746 0.0404403146929757 no 199 0.0615996654673974 81 691249 YDR170C SEC7
SGTC_412 gemfibrozil 100 µM 1.53778278993383 0.0408052518889428 no 200 0.0620508664647242 88 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.5377496789273 0.0408085297152652 no 201 0.0620549158485255 82 16623 A steroid.
SGTC_3153 9100258 49.47 µM 1.53040983066878 0.0415404279183097 no 202 0.0629576585775928 84 25236848
SGTC_2932 9016711 44.54 µM 1.52849824869197 0.0417327782628228 no 203 0.0631944390131036 96 7117328
SGTC_1284 0929-0043 16 µM 1.52523457679098 0.0420628474891535 no 204 0.0636002996033979 87 1239883
SGTC_2557 derrustone 83.84 µM 1.52480468314027 0.0421064815523302 no 205 0.0636539107440935 100 629853 An antioxidant.
SGTC_2486 5283202 22.39 µM 1.52030769945964 0.0425651232722312 no 206 0.0642168299196256 84 1377751
SGTC_1053 3366-3204 134 µM 1.5198032772022 0.0426168196845714 no 207 0.0642802126141128 106 3632071 YPR165W RHO1
SGTC_2322 7413319 38.22 µM 1.51842145392058 0.0427586978080113 no 208 0.0644540933269862 117 1840400
SGTC_1933 st074711 15.9 µM 1.5163132948214 0.0429758874886032 no 209 0.064720075746456 118 17250958
SGTC_1970 st070122 35.8 µM 1.5159998355345 0.0430082571136862 no 210 0.0647596969965288 120 102928
SGTC_3300 9124615 50.48 µM 1.51086591511742 0.0435412242167011 no 211 0.0654113082910618 80 24824903
SGTC_2989 9073649 71.4286 µM 1.51008735175482 0.0436225126618883 no 212 0.0655105682292738 112 21367202
SGTC_1954 st077032 68.9 µM 1.50703762982446 0.0439421089616302 no 213 0.0659005060381371 86 698907
SGTC_2965 9082772 38.63 µM 1.49898120148703 0.0447954740335512 no 214 0.0669392544558842 59 16459634
SGTC_216 k038-0035 28.382 µM 1.49532826448249 0.0451867782717014 no 215 0.0674143960210642 113 4444231 YPR107C YTH1
SGTC_168 3970-0862 530.542 µM 1.49487047472294 0.0452360102589392 no 216 0.0674741245903559 161 3135186
SGTC_308 4092-1169 104 µM 1.4921108183029 0.0455337062618151 no 217 0.0678350481418243 100 2268590 YDL196W YDL196W
SGTC_2558 carylophyllene oxide 100 µM 1.49175950459647 0.0455717167586294 no 218 0.0678811017348892 88 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1218 1348-1416 30.7 µM 1.48776954834983 0.0460052039515273 no 219 0.0684058395025053 92 6787668
SGTC_2338 7999974 200 µM 1.48729645472955 0.0460568219678621 no 220 0.0684682652343944 108 315925
SGTC_510 ag-490 170 µM 1.48686574013603 0.046103856567527 no 221 0.0685251371733761 72 5328779
SGTC_2959 9079155 11 µM 1.4854939801662 0.0462539117133671 no 222 0.0687065084381554 111 16189457
SGTC_731 3966-0296 387 µM 1.48521725952207 0.0462842293297551 no 223 0.0687431406993046 85 660956
SGTC_1144 3486-0183 12.5 µM 1.48142786185341 0.0467010045825712 no 224 0.0692462973902309 108 6744069
SGTC_1952 st077036 64.1 µM 1.47990795842168 0.0468690142787419 no 225 0.0694489057658401 111 2937007
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.4793028864436 0.0469360335311074 no 226 0.0695296908870303 90 115019
SGTC_348 k064-0012 10.7 µM 1.47769261922774 0.0471147651388801 no 227 0.0697450354167033 105 5066323
SGTC_2217 6934799 96.0675 µM 1.47655770206666 0.047241062764877 no 228 0.0698971185196767 84 675606
SGTC_2860 9025725 38.96 µM 1.47125100553367 0.0478352158689858 no 229 0.0706116239654713 99 40546248
SGTC_916 4466-0038 42 nM 1.47081278552831 0.0478845464856975 no 230 0.0706708768899379 140 5722064 YGL116W CDC20
SGTC_3204 9114183 49.47 µM 1.45623360054816 0.0495490746094642 no 231 0.072664026959226 103 17027248
SGTC_1212 0520-0165 585 µM 1.44950519543513 0.0503326846884032 no 232 0.0735982752428381 109 5403258
SGTC_2155 5570423 76 µM 1.44895497043489 0.0503971999264579 no 233 0.0736750790990467 99 797402
SGTC_301 4119-0100 24.5 µM 1.44717330998585 0.0506065562397079 no 234 0.0739241948819071 107 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1276 0871-0068 94.2 µM 1.44601654910917 0.0507428534100324 no 235 0.0740862800803264 123 3414906
SGTC_3080 9117754 49.47 µM 1.43907453789921 0.0515669583090776 no 236 0.0750647026244837 112 9550191
SGTC_910 3454-3003 490 µM 1.43884560283671 0.0515943160100874 no 237 0.0750971362860451 124 820824
SGTC_2381 9035592 200 µM 1.42968523209551 0.0526984788863155 no 238 0.0764036903302346 106 4749657
SGTC_1403 3909-7815 62.9 µM 1.42690311483227 0.0530375136290335 no 239 0.0768039114531 102 6615483
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.4218277233659 0.0536604654660085 no 240 0.077538134664157 93 97141
SGTC_401 neomycin 50 µM 1.42147003090155 0.0537045862240884 no 241 0.0775900800184164 94 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_636 0kpi-0074 126 µM 1.4096593021381 0.0551776230843625 no 242 0.0793201536587087 105 616434
SGTC_3218 9131285 49.47 µM 1.40564802362523 0.0556851090359775 no 243 0.079914334077229 109 17156417
SGTC_2628 lathosterol 100 µM 1.39865032878572 0.0565792313779011 no 244 0.0809589330647798 105 6710616
SGTC_410 α-linolenic acid 100 µM 1.39718146944216 0.0567683419088374 no 245 0.081179503823332 121 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2531 methyl deoxycholate 70.07 µM 1.3909287665099 0.0575789317489398 no 246 0.0821235143205434 116 16667744 Haematoxylin.
SGTC_3065 9113888 49.47 µM 1.39050595883378 0.057634070743827 no 247 0.0821876455530329 116 16648368
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.38854308649037 0.0578905959916978 no 248 0.0824858670764353 114 91467 include heat shock
SGTC_2357 9067248 200 µM 1.38152891924768 0.0588146084664756 no 249 0.0835581961425823 113 9150235
SGTC_1126 isoteolin 1.0172 µM 1.38093687960074 0.0588931276104168 no 250 0.0836491846241794 107 133323
SGTC_2667 digitoxin 100 µM 1.37990095673895 0.0590307145274976 no 251 0.083808570997406 72 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2772 vinpocetine 57.06 µM 1.37893887166803 0.0591587203349687 no 252 0.0839568009393443 114 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_703 3875-0075 71.8 µM 1.37832468882119 0.0592405513925619 no 253 0.0840515319461671 132 2850814
SGTC_704 1310-0270 142 µM 1.37682560572046 0.0594406554447365 no 254 0.0842830861161298 107 5718033
SGTC_2597 laccaic acid a 100 µM 1.37536363924587 0.0596363149614677 no 255 0.0845093678991647 116 5491415 A textile dye.
SGTC_2895 9054447 58.44 µM 1.37452521792624 0.0597487509911459 no 256 0.0846393434216585 112 2697450
SGTC_2055 5235184 200 µM 1.3735427782294 0.0598807117729155 no 257 0.0847918359733019 105 2836034
SGTC_1511 0906-3109 28.5 µM 1.37289565264248 0.0599677579744663 no 258 0.0848923941424562 122 2882180
SGTC_2146 5545642 200 µM 1.36994448344278 0.0603659828946247 no 259 0.0853521161588408 119 825326
SGTC_1636 st007707 68.9 µM 1.36384825262691 0.0611951468587367 no 260 0.0863076650506478 116 403051
SGTC_3323 9138564 53.9225 µM 1.36322281522084 0.061280715147533 no 261 0.086406149450581 115 43912313 YNL103W MET4
SGTC_37 0566-0070 1.56 µM 1.36197439105079 0.0614517959566372 no 262 0.0866029835850002 111 1626686
SGTC_1451 4152-0210 104 µM 1.35986007598851 0.0617423868521726 no 263 0.0869371035010633 110 659563
SGTC_2533 agelasine 13.65 µM 1.35299347370083 0.0626935343704816 no 264 0.0880288576684989 118 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1349 flufenamic acid 69 µM 1.34938215207275 0.063198329017514 no 265 0.088607125275217 122 3371 A non-steroidal anti-inflammatory.
SGTC_558 k064-0027 21.3 µM 1.3431456952233 0.0640775132490357 no 266 0.0896124008581985 129 5088526
SGTC_1026 k007-1105 30.6 µM 1.33840331863214 0.0647524115822454 no 267 0.0903824988390789 144 7066794
SGTC_1936 st074407 74.3 µM 1.33714966674901 0.0649317408791326 no 268 0.090586893885602 141 809813
SGTC_1907 st060210 83.7 µM 1.32967786331169 0.0660085564368583 no 269 0.0918122157257561 134 688793
SGTC_2073 5212005 126 µM 1.32726085899696 0.0663598345008761 no 270 0.0922112033490375 116 691789
SGTC_1929 genistein trimethyl ether 50.5 µM 1.32656094005799 0.0664618278264604 no 271 0.0923269819484428 122 136420
SGTC_979 1426-2828 121 µM 1.32621619129743 0.0665121097669624 no 272 0.0923840488378643 127 747872
SGTC_1020 4335-0961 93.3 µM 1.32527485295366 0.0666495548619893 no 273 0.0925400032185041 130 669075
SGTC_17 0960-0276 49.807 µM 1.32469803224702 0.0667338851816196 no 274 0.0926356630450694 135 6821114
SGTC_112 phenothiazine 287.218 µM 1.3246442587248 0.066741750995234 no 275 0.0926445845606392 114 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.32352060992578 0.0669062788134235 no 276 0.092831153512386 104 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2823 7987624 58.44 µM 1.32249879507505 0.0670561680491666 no 277 0.0930010551646692 135 2239440
SGTC_583 1488-1091 88.9 µM 1.32096844301831 0.0672811397785657 no 278 0.0932559432964978 143 4303273
SGTC_317 4495-0002 170 µM 1.32046238219585 0.0673556622598565 no 279 0.0933403438313535 110 15991618
SGTC_1856 st057054 55.7 µM 1.31646046936358 0.067947232846189 no 280 0.0940097690273383 131 1266018
SGTC_2592 piperlongumine 83.33 µM 1.31256892912592 0.0685263276206007 no 281 0.0946641225664635 126 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2900 5328528 85.29 µM 1.31172930887574 0.0686517682429663 no 282 0.0948057420176903 118 795359
SGTC_2329 6138490 200 µM 1.31133550260965 0.0687106645111089 no 283 0.0948722194099414 121 720019
SGTC_1854 st056233 32.9 µM 1.31058909851672 0.0688224009604358 no 284 0.0949983121337837 129 5393174
SGTC_52 0329-0193 875 nM 1.30623417912837 0.0694771261827874 no 285 0.0957364664476032 122 3739292
SGTC_387 norethindrone acetate 66.7 µM 1.30508603246036 0.0696505367916098 no 286 0.0959317771581488 119 541197
SGTC_2086 5274770 176.623 µM 1.30037441537607 0.0703656481672963 no 287 0.0967363371640955 128 689278
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.29885080675298 0.0705980996570448 no 288 0.0969975673503426 126 94937 An inhibitor of serotonin biosynthesis.
SGTC_300 r073-0011 5.04 µM 1.29805392807431 0.0707199114099711 no 289 0.0971344021907948 126 2735780
SGTC_2406 ethylparaben 405.7 µM 1.29672722727936 0.0709230705430096 no 290 0.0973625288267221 110 8434 A possible steroid mimic.
SGTC_1092 toremifene 6.32 µM 1.29381850193345 0.0713700554345174 no 291 0.0978640601414412 132 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3042 9091578 49.47 µM 1.29356207571218 0.0714095640252671 no 292 0.0979083645936712 111 25236497
SGTC_1413 3910-0535 34.4 µM 1.29237410563813 0.0715928182720596 no 293 0.098113809843441 136 2876951
SGTC_667 1498-1044 59 µM 1.29154802045173 0.0717204613106634 no 294 0.098256857479066 122 6739982
SGTC_830 4076-0286 57.8 µM 1.29056919790279 0.0718719305369847 no 295 0.09842655128914 135 6866659
SGTC_234 nsc-17383 10.7 µM 1.28700865507443 0.0724249813446773 no 296 0.0990456357183494 132 408974
SGTC_2127 5253358 187.912 µM 1.28580701027052 0.0726123640689405 no 297 0.0992552115245607 113 20612
SGTC_3205 9113483 49.47 µM 1.28450133317651 0.0728163901139588 no 298 0.0994832987039749 118 17018033
SGTC_3265 9137266 49.47 µM 1.28137991304764 0.073305924096181 no 299 0.100030128040425 96 17224265
SGTC_355 1311-2252 105 µM 1.27501650551893 0.0743116932315017 no 300 0.101151699974476 132 5338538
SGTC_3061 glucosamine 200 µM 1.27310820951973 0.0746153538069824 no 301 0.101489823095238 105 91431 and experimental redox chemotherapeutic
SGTC_2065 5221596 34.26 µM 1.26891350172872 0.0752861709720263 no 302 0.102235958118718 136 788581
SGTC_3197 9113331 49.47 µM 1.2672493537361 0.0755535714757557 no 303 0.102533071802304 133 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2874 9043904 71.43 µM 1.26709485103596 0.0755784341191725 no 304 0.102560688220875 140 4463428
SGTC_2198 6589944 200 µM 1.26563378600432 0.0758138576560905 no 305 0.102822112100381 113 5290268
SGTC_2354 9060492 162 µM 1.26332728713088 0.076186643408945 no 306 0.103235791840737 143 6471895
SGTC_1175 0741-0056 27.6 µM 1.26258365570674 0.0763071290932304 no 307 0.10336942236814 136 765927
SGTC_2200 6600604 21.907 µM 1.26050039644969 0.0766454378991987 no 308 0.103744452482908 149 2904777
SGTC_3240 9133527 49.47 µM 1.25988522406225 0.0767455560399112 no 309 0.103855384887687 123 17617455
SGTC_1872 amphotericin b 148 nM 1.25750974308292 0.0771330946276917 no 310 0.104284556616967 116 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_201 4262-0159 12.803 µM 1.25151599742926 0.0781175289041024 no 311 0.1053731404213 120 1341029
SGTC_1796 st049173 110.4 µM 1.25062929484631 0.0782639698068072 no 312 0.105534878741487 137 94134
SGTC_2696 st077691 74.316 µM 1.24867964641805 0.0785866905952737 no 313 0.105891134091789 140 757133
SGTC_1495 4469-0029 237 µM 1.24501867832581 0.07919540589481 no 314 0.106562442232174 131 793680
SGTC_1850 st056238 17 µM 1.2447693531373 0.0792369910937151 no 315 0.106608272233863 139 5393177
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.24023082578193 0.0799968690378325 no 316 0.107445014891103 168 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1705 st027868 56.3335 µM 1.23918461371851 0.0801728134673658 no 317 0.107638568638388 114 292948
SGTC_2113 5491891 107.031 µM 1.23889414693153 0.0802217139243895 no 318 0.107692350776943 137 789979
SGTC_2517 totarol 10 µM 1.23789812133795 0.0803895673031523 no 319 0.107876919513497 117 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3083 9117465 49.47 µM 1.23330372081718 0.0811672668445838 no 320 0.108731235108634 128 16420915
SGTC_1000 4048-0884 8.67 µM 1.23270003525808 0.081269873948093 no 321 0.108843849343099 129 13040088
SGTC_233 rapamycin 362 pM 1.22887385912422 0.0819224774356461 no 322 0.109559551938502 134 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_318 1488-0629 67.2 µM 1.22649871259159 0.0823295711298374 no 323 0.110005529745324 121 3662576
SGTC_2109 5483026 200 µM 1.21736312185298 0.0839095915623155 no 324 0.111733043871191 191 759335
SGTC_1181 1222-0449 220 µM 1.21442964756548 0.0844217421096189 no 325 0.11229184988669 140 658318
SGTC_3249 9135183 49.47 µM 1.21437152870623 0.0844319126294433 no 326 0.112302941256194 138 4902779
SGTC_303 1348-1668 34.2 µM 1.20851552562674 0.0854614043558093 no 327 0.113424513766559 137 5380509
SGTC_730 1436-0052 41.2 µM 1.20632832226402 0.0858483190818284 no 328 0.113845460671952 114 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2743 auranofin 4.32 µM 1.20327927560648 0.0863898790011537 no 329 0.114434133049708 104 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_822 1487-0950 154 µM 1.20326445520957 0.0863925175671702 no 330 0.114436999671549 133 1958375
SGTC_1365 1672-3266 55.4 µM 1.20284041309378 0.0864680379118298 no 331 0.11451904129081 163 6415873
SGTC_1009 4106-0057 9.87 µM 1.20197333622573 0.0866226147491256 no 332 0.114686929438029 165 2928005
SGTC_488 nitrendipine 139 µM 1.19863456460567 0.0872197584333277 no 333 0.115335035996365 126 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_727 3032-0951 202 µM 1.19012000037438 0.0887565060361393 no 334 0.116999615173446 139 3652836
SGTC_2347 9049783 174.81 µM 1.1899099673331 0.0887946669644195 no 335 0.117040890235549 154 6467988 YPL169C MEX67
SGTC_633 0437-0093 97.7 µM 1.1892176081789 0.0889205482983164 no 336 0.117177023637608 134 2831118
SGTC_63 0099-0242 26.702 µM 1.18867315691057 0.0890196310262688 no 337 0.117284153776945 171 3898502 YLR359W ADE13
SGTC_1119 parthenolide 318.541 nM 1.18787459280953 0.0891651074654371 no 338 0.117441410448037 163 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_637 1181-0519 7.26 µM 1.1866413119452 0.0893901248314785 no 339 0.117684566648389 147 6252091 YGR060W ERG25
SGTC_3136 9095672 49.47 µM 1.18558375940157 0.0895834159943455 no 340 0.117893359497622 143 17217380
SGTC_1594 piperine 70.1 µM 1.18515061486545 0.0896626724101902 no 341 0.117978950936048 136 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1811 st050069 61.5 µM 1.18474054284951 0.0897377550679604 no 342 0.118060023633381 133 3877702
SGTC_380 3970-0968 6 µM 1.18314815146407 0.0900297591784981 no 343 0.118375218660821 138 2891601
SGTC_3260 9137109 49.47 µM 1.18257563699508 0.0901349161454285 no 344 0.118488686376182 131 17478346
SGTC_3210 9128157 49.47 µM 1.18109474258656 0.0904073436148722 no 345 0.118782544126983 148 17590849
SGTC_83 0170-0301 39.027 µM 1.18021504777004 0.0905694627492431 no 346 0.118957347810659 127 3089716
SGTC_33 0986-0033 35.816 µM 1.17899409406105 0.0907948300375468 no 347 0.119200263780464 111 2848082
SGTC_971 1315-0384 26.7 µM 1.17856648295763 0.0908738580854111 no 348 0.119285422272387 146 6769120
SGTC_1643 st009866 20.2 µM 1.17286293532397 0.0919328319749503 no 349 0.120425387567937 137 3156273 YOR207C RET1
SGTC_34 0469-0683 81.75 µM 1.17229486351821 0.0920388038815737 no 350 0.120539346559834 127 3690923
SGTC_1506 4226-2149 212 µM 1.17041355689291 0.0923904011430018 no 351 0.120917291304443 142 991114
SGTC_2841 9004761 38.96 µM 1.16872965337077 0.0927059478249833 no 352 0.121256285350093 123 2991039
SGTC_2440 5628896 157.78 µM 1.16860352138644 0.0927296157458666 no 353 0.121281704416139 137 5522048
SGTC_2925 9010536 32.5 µM 1.16751643079401 0.0929337871205213 no 354 0.121500938416946 128 2994177
SGTC_1450 4112-4260 37.6 µM 1.16624361841359 0.0931732618748027 no 355 0.121757980854823 159 1633175
SGTC_906 1165-0455 526 µM 1.16242354836111 0.0938947311463691 no 356 0.122531731282036 152 3252859
SGTC_132 0417-1715 25.805 µM 1.16221628618846 0.0939339928634727 no 357 0.122573810424893 144 6769098
SGTC_1583 clindamycin 39.6 µM 1.1581546389634 0.0947058384105232 no 358 0.123400467908287 151 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_210 3551-0445 56.827 µM 1.15775085246093 0.094782825725364 no 359 0.123482862554982 139 2865180 YOR207C RET1
SGTC_1699 st031318 29.054 µM 1.15644232542532 0.0950326308463177 no 360 0.123750138764479 162 5340658
SGTC_1134 3477-0009 42.5 µM 1.15625888926303 0.0950676885554409 no 361 0.123787639285294 162 3973534
SGTC_2644 guaiazulene 100 µM 1.15308083025945 0.0956765815384941 no 362 0.124438604545931 126 3515 A coloring agent.
SGTC_1664 st014217 9.02 µM 1.15173330280713 0.0959356224692836 no 363 0.124715341420512 159 3982782
SGTC_499 genistein 192 µM 1.15018177439364 0.0962345177735703 no 364 0.125034505609314 135 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3306 9127676 59.7925 µM 1.1479595151042 0.0966638180244558 no 365 0.125492638600033 139 41905287
SGTC_883 0850-0245 24.6 µM 1.13932532935509 0.0983451373819345 no 366 0.127283743763095 172 6823229 YPR165W RHO1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.1391293707725 0.098383543036556 no 367 0.127324599420884 125 4000243
SGTC_3272 9137413 49.47 µM 1.1389637110217 0.0984160190307677 no 368 0.127359145150652 164 17614870
SGTC_1852 st056254 31.4 µM 1.13761852876946 0.0986800197329031 no 369 0.127639903108634 152 442583
SGTC_1795 st049545 62.3 µM 1.13667127843601 0.0988662344922844 no 370 0.127837865211711 122 5291882
SGTC_1883 5-benzylidenerhodanine 20 µM 1.13652235522853 0.0988955338638847 no 371 0.127869007482699 154 1273210
SGTC_1478 0453-0656 35.7 µM 1.13641878878294 0.0989159134241138 no 372 0.127890668022861 168 5258496
SGTC_193 1273-0060 1.558 µM 1.13369347185124 0.0994532995783083 no 373 0.128461574467857 160 2847393 YHR072W ERG7
SGTC_2459 5811157 9.22 µM 1.12787486087182 0.100607766124656 no 374 0.129686386041087 151 2870684 YBR192W RIM2
SGTC_125 0133-0007 11.75 µM 1.12671652686364 0.100838752451127 no 375 0.12993117629641 154 26541
SGTC_1655 st012546 55.1 µM 1.12470375235978 0.101241044263531 no 376 0.130357295552989 140 720985 YLR208W SEC13
SGTC_519 k048-0011 62.8 µM 1.12434893979106 0.101312081475725 no 377 0.130432512110869 159 6836379
SGTC_2927 9011802 47.9 µM 1.12369855134946 0.101442390369978 no 378 0.130570465596542 143 43912568
SGTC_1838 st055369 84.5 µM 1.12270637835083 0.101641412781861 no 379 0.1307811090847 141 676036
SGTC_1368 1852-0141 284 µM 1.11702331267618 0.102786872896984 no 380 0.131992178751465 160 2838987
SGTC_2760 etidronate 98.04 µM 1.11672825400763 0.102846599084061 no 381 0.132055266710196 149 3305 A chelator and antioxidant.
SGTC_2905 7799065 20.05 µM 1.11503305144542 0.103190233019718 no 382 0.13241812929161 147 1296806
SGTC_2314 7727897 200 µM 1.11415168239496 0.103369224124023 no 383 0.132607059908294 131 900724
SGTC_2195 6536160 144.242 µM 1.11382904015851 0.103434803612032 no 384 0.132676268034578 133 3834386
SGTC_2650 prasterone 100 µM 1.11089856420122 0.104031828335818 no 385 0.13330600679608 127 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1341 1486-1360 280 µM 1.11017535637638 0.104179550842905 no 386 0.133461734957239 168 3976547
SGTC_174 3553-0389 74.3 µM 1.10899452677229 0.104421073947649 no 387 0.133716271556384 150 738071
SGTC_624 k048-0052 28 µM 1.10778583476257 0.104668715873363 no 388 0.13397715954544 146 6835531
SGTC_1371 2421-0008 32.7 µM 1.10566223656148 0.105104837340295 no 389 0.134436370480079 186 2827552
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.10533620637658 0.105171910153757 no 390 0.134506967446303 156 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2353 9059630 146.67 µM 1.102938548271 0.105666121872374 no 391 0.135026926255774 158 4779114
SGTC_1546 5-methoxyflavanone 78.7 µM 1.09817895108397 0.106652153256883 no 392 0.136063177808131 142 147795
SGTC_2359 9039622 200 µM 1.09647874944822 0.107005983784908 no 393 0.136434659031765 164 6463596
SGTC_110 0850-0284 111.64 µM 1.09607014490996 0.10709114490683 no 394 0.136524039342996 130 3906265
SGTC_504 lovastatin 124 µM 1.0926282079864 0.107810452040844 no 395 0.137278536232361 172 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1676 st018489 23.4 µM 1.0897853888054 0.108407172569375 no 396 0.137903845840899 146 3696235
SGTC_2838 9002687 71.43 µM 1.08888474243952 0.108596717085063 no 397 0.138102357675869 182 6457060
SGTC_1945 st075991 56.6 µM 1.08654415824379 0.109090416524525 no 398 0.138619157689757 156 1084980
SGTC_1613 st002381 52.1 µM 1.08627866283789 0.10914651916862 no 399 0.138677862057256 162 551167
SGTC_810 3825-7150 143 µM 1.08604355541621 0.109196217741837 no 400 0.138729861396569 126 22330411 YGL099W LSG1
SGTC_1104 tacrolimus 29.8 µM 1.08538224431313 0.109336097275977 no 401 0.138876196556079 178 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1192 1488-0095 21.4 µM 1.08493772591813 0.109430193452332 no 402 0.138974618797506 153 915875
SGTC_1267 0828-0272 9.49 µM 1.08460746593315 0.109500140923616 no 403 0.139047773459157 169 745334
SGTC_3048 9093155 49.47 µM 1.08322828550299 0.109792591697946 no 404 0.139353553863219 149 25236002
SGTC_1036 k216-0215 33.5 µM 1.07946396305053 0.110593656415076 no 405 0.140190475139168 148 622330
SGTC_974 1326-0144 138 µM 1.07886332577396 0.110721861286101 no 406 0.140324329935471 158 5411856
SGTC_1108 betulinic acid 729.144 nM 1.07833048773131 0.110835683658006 no 407 0.140443147986864 151 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1730 st033808 45.1 µM 1.07772891584791 0.11096428935387 no 408 0.140577375133023 166 1045166
SGTC_3145 9085516 49.47 µM 1.07557300578133 0.111426063616959 no 409 0.141059132726757 162 25236195
SGTC_1501 4491-0275 38.4 µM 1.07503558873094 0.111541386792443 no 410 0.14117939755655 169 5104718
SGTC_3284 9108171 64.8615 µM 1.0696695452304 0.112697560396872 no 411 0.142384039633691 166 8687505
SGTC_448 monastrol 171 µM 1.06659124058917 0.11336466542156 no 412 0.143078228827949 174 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3190 9110366 49.47 µM 1.06484636765319 0.113744048383445 no 413 0.143472729252008 147 17123768
SGTC_1030 k029-0042 36.7 µM 1.06155015502837 0.114463202567086 no 414 0.144219976152502 158 6080581
SGTC_2639 lactacystin 53 µM 1.06109160858207 0.114563502242917 no 415 0.14432413551395 162 3870 A proteasome inhibitor.
SGTC_1694 st024011 44.9 µM 1.05795084938081 0.115252174647426 no 416 0.145038925471137 177 2787533
SGTC_2328 6201408 200 µM 1.05604216504745 0.115672125599531 no 417 0.145474475701623 188 2890418
SGTC_3242 9133940 49.47 µM 1.05491385545764 0.115920888185037 no 418 0.145732362419688 146 17248444
SGTC_844 0330-0132 15.3 µM 1.05247028485606 0.116460932739598 no 419 0.14629191842119 174 2828079
SGTC_790 1575-0012 79.1 µM 1.05142312683438 0.116692906695952 no 420 0.146532149349795 186 378741 YLR208W SEC13
SGTC_3296 9122258 64.045 µM 1.04989666976274 0.117031644979582 no 421 0.146882811440643 154 4730474
SGTC_1402 3909-7673 35.9 µM 1.04893076578062 0.117246349733975 no 422 0.14710499221004 167 5328014
SGTC_955 1216-0110 33 µM 1.04807936318498 0.117435833921504 no 423 0.14730102170585 163 3619719
SGTC_433 pimozide 108 µM 1.04231886709872 0.118723560677188 no 424 0.148631933938787 156 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2125 5246583 200 µM 1.04193100343513 0.118810622491564 no 425 0.148721834409044 189 835267
SGTC_3343 9148379 18.9835 µM 1.04127945554473 0.118956973670318 no 426 0.148872934374857 167 1955036
SGTC_1642 st009582 77.7 µM 1.0371436169489 0.11988893790143 no 427 0.149834465183183 194 6739311
SGTC_1202 1988-0068 29.6 µM 1.03614895435292 0.120113839590101 no 428 0.15006632832444 153 2850480
SGTC_3053 9095903 49.47 µM 1.03577765871337 0.12019786885621 no 429 0.150152941339907 212 17174018
SGTC_2977 9011197 71.43 µM 1.03544639072119 0.120272874275271 no 430 0.15023024513315 191 2704722
SGTC_1174 0739-0097 51.1 µM 1.03501399948657 0.120370825533861 no 431 0.150331186669683 187 728447
SGTC_692 k241-0027 77.8 µM 1.03471692268606 0.120438156046989 no 432 0.150400565299939 167 3600480
SGTC_1275 0867-0008 21.1 µM 1.03461479437333 0.120461308886487 no 433 0.15042442103705 167 3422836
SGTC_169 k015-0017 16.025 µM 1.03411821054388 0.120573930822389 no 434 0.150540451961635 190 1840002
SGTC_1268 0828-0275 2.46 µM 1.03339605884883 0.120737842331898 no 435 0.150709295044914 184 745337
SGTC_2393 9031399 185.94 µM 1.03291701035839 0.120846661609805 no 436 0.150821368788542 183 1526623 YDL150W RPC53
SGTC_786 4544-0069 423 µM 1.03255770453408 0.1209283257761 no 437 0.150905465052868 181 748821 YLR208W SEC13
SGTC_1764 st044502 93.5 µM 1.02612108407804 0.122397843493988 no 438 0.152417256601673 164 8407
SGTC_1565 sinapyl alcohol 95.1 µM 1.02577935272318 0.122476211589279 no 439 0.152497800266535 189 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1982 st072467 71.9 µM 1.02540973408568 0.122561014610614 no 440 0.152584948556323 181 3163533
SGTC_1840 st055363 71 µM 1.02522334800515 0.122603793505252 no 441 0.15262890699827 176 676033
SGTC_942 3253-1115 227 µM 1.02460447540968 0.122745910819097 no 442 0.152774925981114 187 46497897
SGTC_3181 9108277 49.47 µM 1.02350707637089 0.122998200498958 no 443 0.153034077913671 181 17097298
SGTC_1393 3470-5649 58.2 µM 1.02254943514692 0.123218657006571 no 444 0.15326046385892 151 4108395
SGTC_172 1112-0046 2.638 µM 1.02235473544595 0.123263512252877 no 445 0.153306517909073 157 2802135 YIL048W NEO1
SGTC_1931 st074438 57.1 µM 1.01699769290385 0.12450216721618 no 446 0.154577263466998 225 2787313
SGTC_1879 gemcitabine 100 µM 1.01369748259981 0.12526955951621 no 447 0.155363562833067 180 60750 A nucleoside analog which inhibits DNA replication.
SGTC_764 1951-2361 146 µM 1.01285752654173 0.125465399174349 no 448 0.155564109183769 186 5438930
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.00973757995778 0.126194699716753 no 449 0.156310516361189 181 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_273 hydroxyurea 18.1 mM 1.00815193768518 0.126566480517756 no 450 0.15669076354655 197 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3195 9113082 49.47 µM 1.00694886616322 0.126849069645511 no 451 0.156979673693254 172 17018038
SGTC_1353 1498-1206 8.11 µM 1.00564902962739 0.127154881220858 no 452 0.157292214947886 179 6756808
SGTC_51 1013-0126 23.419 µM 1.00450787809977 0.12742378164413 no 453 0.157566937932599 153 1627850
SGTC_602 3130-1533 38.1 µM 1.00305864265876 0.127765848512859 no 454 0.157916283803251 204 720941
SGTC_1724 st037281 8.293 µM 1.00263922774862 0.127864963091718 no 455 0.15801748080631 188 574124 YDL195W SEC31
SGTC_3025 9087895 49.47 µM 1.00081830410845 0.128295896502851 no 456 0.158457329307862 188 17173641
SGTC_2745 rifampicin 24.3 µM 0.99895730560731 0.128737354796091 no 457 0.158907686985773 120 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_453 enantio-paf c16 10 µM 0.995146839888845 0.129644542829827 no 458 0.159832426176529 214 13871343 A lipid and platelet activating factor
SGTC_483 fpl-64176 144 µM 0.994657072874996 0.129761465929708 no 459 0.159951539615938 168 3423
SGTC_1746 st038117 42 µM 0.994513725355777 0.129795701391739 no 460 0.159986413327504 186 2898218
SGTC_3108 9121785 49.47 µM 0.987452733986283 0.131489812886704 no 461 0.161710371674044 192 17140271
SGTC_772 k072-0172 35.3 µM 0.98596080135006 0.131849710022235 no 462 0.162076174320787 152 5861980
SGTC_801 0866-0028 10.1 µM 0.98582818481357 0.131881733806983 no 463 0.162108716246197 179 6849771
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.980936209782291 0.133066781662567 no 464 0.163312099869196 191 756377
SGTC_421 streptovitacin 30 mM 0.979595330932951 0.133392876385196 no 465 0.1636429552981 183 91467 include heat shock
SGTC_1791 st048313 56.1 µM 0.978955063157364 0.133548779915693 no 466 0.163801091705498 170 1204976
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.97807321342178 0.133763713100126 no 467 0.164019057507661 212 688798
SGTC_599 1935-0052 86.5 µM 0.977681063193952 0.133859368194112 no 468 0.164116045251499 164 9557311
SGTC_2945 9067681 61.76 µM 0.976356587737914 0.134182787856811 no 469 0.164443893337487 236 16456930
SGTC_2126 5251174 33.877 µM 0.975057415658921 0.13450054984115 no 470 0.164765890220396 175 790722
SGTC_1093 fluphenazine 7.97 µM 0.97348835065891 0.134885012627672 no 471 0.16515532360227 204 6602611 An atypical antipsychotic.
SGTC_2414 st077232 92.9 µM 0.972965069132317 0.13501339803664 no 472 0.165285331599117 159 729801
SGTC_2056 5235370 200 µM 0.972484656066003 0.13513133957902 no 473 0.165404747328096 176 5511916
SGTC_1633 st005664 67.9 µM 0.972251412189361 0.135188626484469 no 474 0.165462744616443 178 2063822
SGTC_2788 5282734 71.43 µM 0.971922272866326 0.135269494543409 no 475 0.165544609177496 190 743706
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.970101474750424 0.135717455591727 no 476 0.165997956994367 169 77254
SGTC_1986 st071812 45 µM 0.969719351021607 0.135811596265143 no 477 0.166093201070144 185 11838594
SGTC_3014 9081533 49.47 µM 0.969295559664345 0.135916054538126 no 478 0.166198872056589 217 21367265
SGTC_837 0091-0265 12.5 µM 0.968941358293117 0.136003402105873 no 479 0.166287224315783 203 759367
SGTC_3257 9139206 32.98 µM 0.968042619214468 0.136225207427452 no 480 0.166511542577752 188 4910041
SGTC_2170 morpholine 200 µM 0.963245424525726 0.13741332244524 no 481 0.167712187107553 173 121171 Reacts with secondary amines.
SGTC_2601 securinine 100 µM 0.962764185048728 0.137532899712792 no 482 0.167832938926777 239 442872 A GABA receptor antagonist.
SGTC_1454 4239-0054 42.6 µM 0.960984685078217 0.137975682582441 no 483 0.168279934160118 182 1340767
SGTC_3150 9097574 49.47 µM 0.959638219610259 0.13831136146073 no 484 0.168618663263992 171 17217476
SGTC_1389 3405-0187 19 µM 0.958776688578761 0.138526436189001 no 485 0.168835627617383 197 799890
SGTC_3209 9113616 49.47 µM 0.957785110234547 0.138774258191151 no 486 0.169085564466657 200 16649353
SGTC_688 0527-0193 473 µM 0.956347647757176 0.139134054449691 no 487 0.169448312366532 228 4007154
SGTC_657 3534-0529 86.7 µM 0.955371390353381 0.139378772983477 no 488 0.169694958348795 192 1049549
SGTC_2123 5259487 200 µM 0.954680192310311 0.139552212611233 no 489 0.16986972483534 180 2173474
SGTC_1922 5578187 25 µM 0.953250436448868 0.13991144132961 no 490 0.170231598634894 194 1350412
SGTC_2261 9010538 184.68 µM 0.952245027000686 0.140164428286049 no 491 0.170486365148147 217 6457250
SGTC_370 0180-0345 38.7 µM 0.950494607131151 0.140605620149104 no 492 0.170930496410139 172 3989527
SGTC_532 1548-0774 215 µM 0.949676635536723 0.140812112016333 no 493 0.171138292597427 198 5932993
SGTC_5 0352-0601 109.883 µM 0.949357443979599 0.140892745731737 no 494 0.171219423308996 176 762456
SGTC_476 mead acid 10 µM 0.946786326802472 0.141543399968895 no 495 0.171873835275735 189 5312531 An omega 9 fatty acid.
SGTC_1043 0916-0009 19.3 µM 0.945427734434941 0.141888030064284 no 496 0.172220274228595 211 3101130
SGTC_481 bay k-8644 50 µM 0.945110257987798 0.141968645202488 no 497 0.172301294416912 202 2303 A calcium channel antagonist.
SGTC_2141 5621638 7.665 µM 0.943737562161376 0.142317563540424 no 498 0.172651887077775 194 2856238
SGTC_2791 5663188 71.43 µM 0.943426334208039 0.142396753554475 no 499 0.172731439295478 220 54690634
SGTC_236 1509-0011 5.31 µM 0.942968677851629 0.142513255497496 no 500 0.172848462153932 236 3107280
SGTC_2332 7982454 138.89 µM 0.942207076712261 0.142707273114292 no 501 0.173043315750625 214 2981748
SGTC_1691 st019933 84.6 µM 0.941618113805169 0.142857433593145 no 502 0.173194096230321 219 6176082
SGTC_2219 9098279 200 µM 0.940833790525747 0.143057568400018 no 503 0.173395020807337 163 902349
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.938532671320149 0.143645834911495 no 504 0.173985367540987 202 23847180
SGTC_2777 climbazole 1.536 µM 0.937739870001544 0.14384888712291 no 505 0.17418905449554 212 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2436 5633522 8.09 µM 0.936705183556096 0.144114182068039 no 506 0.174455114572779 200 5724242
SGTC_102 gallobenzophenone 83.616 µM 0.936424904506458 0.14418610273091 no 507 0.174527230154839 195 70837
SGTC_1018 4259-0013 28.1 µM 0.936303507295715 0.144217261222805 no 508 0.174558471438245 200 6801262
SGTC_2301 7769476 200 µM 0.933416440600842 0.144959609742965 no 509 0.175302497541149 190 977820
SGTC_689 0833-0039 98 µM 0.930484213009953 0.145716199153361 no 510 0.176060217141604 219 5374726
SGTC_2352 9027995 87.8 µM 0.930145674607736 0.145803721310709 no 511 0.176147832477764 186 2997347
SGTC_1909 st060837 51.5 µM 0.930011223546212 0.14583849067469 no 512 0.176182636702642 206 678937
SGTC_232 clozapine 119 µM 0.927016545211516 0.146614365987664 no 513 0.176958971993374 195 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2375 9072683 200 µM 0.926656041468715 0.146707953451547 no 514 0.177052573927558 211 16798029
SGTC_1497 4476-2978 41.3 µM 0.925958943723596 0.146889035035534 no 515 0.177233658525918 190 1528379
SGTC_932 2857-0803 154 µM 0.925307016257019 0.147058518569157 no 516 0.17740311507826 192 674898
SGTC_1602 st001878 87.6 µM 0.923060589413499 0.147643532937623 no 517 0.177987815577337 222 595405 YLR310C CDC25
SGTC_2020 4017018 200 µM 0.920374661705607 0.148345045483259 no 518 0.178688502514921 200 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1004 4084-0029 199 µM 0.920299905153051 0.148364602291458 no 519 0.1787080293168 188 716894 YLR208W SEC13
SGTC_854 0422-0053 192 µM 0.918915210735616 0.148727159302326 no 520 0.179069961618044 233 3596728
SGTC_1254 0550-0035 264 µM 0.917868570620847 0.149001595604787 no 521 0.179343838877839 202 15121435
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.91777354517936 0.149026528676009 no 522 0.179368717487399 199 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_819 1013-0258 27.7 µM 0.917584275360826 0.149076198183985 no 523 0.179418276680911 209 5753198
SGTC_310 1273-0058 1.06 µM 0.914176488474893 0.14997238526611 no 524 0.180312058150703 174 2734232
SGTC_2707 st078556 66.6 µM 0.914101172646476 0.149992232475134 no 525 0.180331843206272 184 17250899
SGTC_1369 1866-0067 208 µM 0.913244693034223 0.150218054973906 no 526 0.180556931526958 197 3531355
SGTC_2980 9014342 25.29 µM 0.909753035519136 0.151141021911095 no 527 0.18147638378975 221 2996599
SGTC_2092 5303694 80.6725 µM 0.90920044276896 0.151287436530984 no 528 0.181622165269723 206 1963699
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.907546671577617 0.151726182159738 no 529 0.182058890274201 236 6708760
SGTC_2794 7785382 27.27 µM 0.907168257147833 0.151826694300681 no 530 0.182158913523485 207 2205081
SGTC_2299 7976368 114.88 µM 0.907141427401613 0.151833822334005 no 531 0.182166006518777 194 2979718
SGTC_438 sphingosine 6.67 µM 0.906682292531381 0.151955838144116 no 532 0.182287415020421 180 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_170 4197-0004 226 µM 0.906675708826591 0.151957588247525 no 533 0.182289156309496 230 218692
SGTC_2204 7233102 200 µM 0.904773710686731 0.152463744727531 no 534 0.182792640886387 193 2172480
SGTC_1211 1056-0033 32.3 µM 0.904678025786424 0.152489237753896 no 535 0.182817992883865 205 6741922
SGTC_812 4251-0442 148 µM 0.90132933084507 0.153383201753471 no 536 0.183706621628491 212 5723007
SGTC_834 0312-0008 75.7 µM 0.899250267341864 0.153939969694386 no 537 0.18425968544972 197 6385573 YIL048W NEO1
SGTC_1420 4'-methoxyflavone 42 µM 0.897462274039025 0.15441985809213 no 538 0.184736147776053 203 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1055 3448-0672 86 µM 0.89587813430213 0.154845858660525 no 539 0.1851589267427 197 748378
SGTC_2640 pentamidine 10.38 µM 0.892197934027183 0.155838517428359 no 540 0.186143424679597 217 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2417 cerulenin 830 nM 0.888929300234954 0.156723674820927 no 541 0.187020538679718 198 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1695 st026914 34.495 µM 0.887586907188228 0.157088156206358 no 542 0.187381499484171 204 3289191
SGTC_2713 st079149 53.4 µM 0.887364497621001 0.157148597786529 no 543 0.187441345537357 211 3103253
SGTC_104 0074-0074 590.992 µM 0.886193643415021 0.157467038931031 no 544 0.187756594204414 187 3943124
SGTC_3268 9137683 49.47 µM 0.885501361013468 0.157655520658321 no 545 0.187943142941724 270 1953228
SGTC_1790 st045711 43.5 µM 0.883477903746142 0.158207279201331 no 546 0.188489057960662 171 585119
SGTC_1619 st003326 88.7 µM 0.881793104196087 0.158667657882267 no 547 0.18894435070151 185 2849032
SGTC_2154 5570129 200 µM 0.880464219828619 0.159031400243411 no 548 0.18930394003449 234 673366
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.88018539988998 0.159107788151979 no 549 0.1893794407228 207 61125 An anti-inflammatory.
SGTC_1622 st003707 19.4 µM 0.879857443699672 0.159197668609296 no 550 0.189468270564409 187 10140899
SGTC_1784 st039334 36.3 µM 0.879358900727777 0.159334364177001 no 551 0.189603354453243 239 3496984
SGTC_2519 cryptotanshinone 88.04 µM 0.878238606477042 0.159641818136169 no 552 0.189907122523631 215 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_560 2332-1943 155 µM 0.873613932694391 0.160915121850696 no 553 0.191164268029663 218 21177716
SGTC_2646 retinol 96.75 µM 0.86928413655637 0.162113229683601 no 554 0.192345868710598 223 445354 A vitamin A analog and teratogen.
SGTC_1158 4092-0494 91.8 µM 0.86764336797832 0.162568764469893 no 555 0.192794798655529 201 1148199
SGTC_2982 9019404 25.97 µM 0.867165601511174 0.162701565575178 no 556 0.192925640362 202 22333232
SGTC_2320 7373003 200 µM 0.866636556212637 0.162848702575089 no 557 0.193070588612023 217 5415828
SGTC_1326 1431-2094 10.8 µM 0.864643311203638 0.16340383667247 no 558 0.193617296385831 223 616278
SGTC_2012 4023501 200 µM 0.864518005645186 0.163438776254747 no 559 0.193651696739012 236 3477460
SGTC_1401 3807-4679 7.6 µM 0.863323992650064 0.163771952326865 no 560 0.193979678133589 229 3291456
SGTC_521 r062-0005 13.8 µM 0.863217280859344 0.163801750513082 no 561 0.194009007081929 205 2832033
SGTC_175 3793-3120 23.7 µM 0.863014142787278 0.16385848448586 no 562 0.194064845549013 237 5322297
SGTC_1339 1486-1321 22.7 µM 0.862733673483795 0.163936837079156 no 563 0.194141956866481 210 3469382
SGTC_577 r071-0003 38.6 µM 0.861820737562756 0.164192045422785 no 564 0.194393085718327 246 4568517 YMR134W ERG29
SGTC_3131 9127911 49.47 µM 0.86085841222393 0.164461339215493 no 565 0.194658014517823 223 45595681
SGTC_1526 st051518 75 µM 0.860493220960448 0.164563607968192 no 566 0.194758609387649 198 673993
SGTC_652 0437-0092 114 µM 0.859735233328079 0.164776007567517 no 567 0.194967504085731 210 3091274
SGTC_2736 butenafine 14.65 µM 0.85963073432164 0.164805303692298 no 568 0.194996313770691 216 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1193 1488-0126 41.5 µM 0.857419514155511 0.165426006581168 no 569 0.195606539216559 215 1384710
SGTC_1835 st008666 49.2 µM 0.857132997787585 0.1655065439963 no 570 0.195685693257681 199 690455
SGTC_215 1287-0124 461.5 µM 0.8558827679164 0.165858270152772 no 571 0.19603131373376 218 5560863
SGTC_1086 cerivastatin 2.18 µM 0.855849835134482 0.165867541631939 no 572 0.196040422857102 210 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2009 4012297 12.05 µM 0.855490672429424 0.165968677508585 no 573 0.196139783011986 195 45595307
SGTC_785 1270-0111 65.3 µM 0.855266287086165 0.166031881930382 no 574 0.196201873335184 226 6741994
SGTC_1283 0922-0125 16.4 µM 0.854646678250572 0.166206492884728 no 575 0.19637338898885 203 3360884
SGTC_1297 1068-0111 14.1 µM 0.853899877977371 0.166417105027616 no 576 0.19658023359598 233 767057
SGTC_2333 9017922 200 µM 0.851699320968169 0.16703870619547 no 577 0.197190498801991 214 3163164
SGTC_2221 6807166 181.081 µM 0.850937124104355 0.167254356000686 no 578 0.197402140549693 200 674925
SGTC_578 3460-0051 92 µM 0.850506053826509 0.167376398942908 no 579 0.197521898064464 254 2876744
SGTC_2948 9070189 9.45 µM 0.849762411831696 0.167587070829361 no 580 0.197728595711417 202 6473636 YDL196W YDL196W
SGTC_3237 9133362 49.47 µM 0.849754800961887 0.167589227852051 no 581 0.197730711852287 220 43845137
SGTC_2159 5658611 73.75 µM 0.848611960477137 0.167913327138015 no 582 0.198048624718696 206 793844
SGTC_2183 6420625 130.508 µM 0.848591236661131 0.167919207947913 no 583 0.198054392472413 240 2897619
SGTC_686 1319-0111 510 µM 0.847647132175506 0.168187257645353 no 584 0.198317258690117 252 4562600
SGTC_923 1900-2434 73.3 µM 0.847617103028076 0.168195788021454 no 585 0.19832562313403 248 5910570
SGTC_2102 5377816 72.7585 µM 0.846009050148876 0.168652993917879 no 586 0.198773847792825 231 1379702
SGTC_471 1-acyl-paf 4 µM 0.84541605379045 0.168821797646329 no 587 0.198939292138837 213 16759367
SGTC_40 0327-0103 19.753 µM 0.844873230854496 0.168976414027302 no 588 0.199090810969498 205 409036
SGTC_2424 5537928 59.2 µM 0.842256166881859 0.169723128126125 no 589 0.199822290349319 239 5382802
SGTC_276 colchicine 750 µM 0.841417147961426 0.169962968627569 no 590 0.200057141106541 225 2833 A microtubule depolymerizer.
SGTC_315 k915-0449 187 µM 0.840138692219695 0.170328843322831 no 591 0.200415314019959 227 20970215 YNL149C PGA2
SGTC_1710 st031758 61.5 µM 0.839048136288777 0.17064134237305 no 592 0.200721149030441 227 5394341
SGTC_858 0438-0351 2.77 µM 0.838447486213561 0.170813615433967 no 593 0.200889714639334 238 2799119
SGTC_2564 betulinic acid 100 µM 0.83778578967464 0.171003526088136 no 594 0.201075510539889 229 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1307 1187-1599 12.2 µM 0.836135952755503 0.171477626594975 no 595 0.201539212216901 237 1538471
SGTC_1985 st071382 65.5 µM 0.835688611041838 0.171606320247305 no 596 0.201665052002556 235 6123237
SGTC_2818 7996756 12.99 µM 0.832636804075459 0.172485926231165 no 597 0.202524797815816 267 2241621
SGTC_1019 4262-0212 3.4 µM 0.832478491615435 0.172531634098891 no 598 0.20256945682334 238 4677213
SGTC_3015 9080845 49.47 µM 0.828952327070748 0.173551707490816 no 599 0.203565691937929 224 5296973
SGTC_2891 9063876 19.48 µM 0.828562909785089 0.173664595692663 no 600 0.203675891547325 205 6472478
SGTC_1500 4488-1866 171 µM 0.827860388863828 0.173868367659302 no 601 0.203874785021196 242 2900003
SGTC_3224 9130643 49.47 µM 0.827171259999676 0.174068402823542 no 602 0.204069999437436 236 17644395
SGTC_924 2046-0044 21.3 µM 0.826085187897228 0.174383956541062 no 603 0.204377884713073 220 3623589
SGTC_1391 3442-0225 151 µM 0.825960063452676 0.174420334257592 no 604 0.204413373386103 219 5227075
SGTC_2675 theaflavin digallate 100 µM 0.822211330059112 0.175512447238146 no 605 0.205478315753224 225 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2079 5212404 121 µM 0.819996501434571 0.176159722284883 no 606 0.206109050805593 207 758462
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.81919892074001 0.176393181687873 no 607 0.206336465288413 249 442882
SGTC_1776 st049249 45.9 µM 0.815724401013849 0.177412488682409 no 608 0.207328889904948 240 1822314
SGTC_2272 7805186 180 µM 0.815017122625923 0.177620434955192 no 609 0.20753125451448 257 2956062 YPR165W RHO1
SGTC_32 0928-0142 34.1 µM 0.813136897583255 0.178173985753336 no 610 0.208069786816581 242 2244242
SGTC_880 0833-0487 87.2 µM 0.810063128660225 0.17908126281904 no 611 0.208951947121967 249 76075
SGTC_3010 9080089 71.4286 µM 0.809922439063601 0.179122859276607 no 612 0.20899237717247 223 17027233
SGTC_612 0302-0167 22.4 µM 0.808056949108488 0.179674986804491 no 613 0.209528899545064 252 235821
SGTC_639 0833-0042 114 µM 0.807600128947656 0.179810354316158 no 614 0.209660406242558 248 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2177 5811945 192 µM 0.80758046559395 0.179816182509171 no 615 0.209666067902403 231 5343475
SGTC_563 tetrahydrosecaminediol 614 µM 0.807288400176798 0.179902764297934 no 616 0.209750172740427 219 334274 A psychoactive constituent of the cannabis plant.
SGTC_302 1094-0063 18.9 µM 0.807102654355962 0.179957841626313 no 617 0.20980367149321 246 5440289
SGTC_2670 beta-carotene 100 µM 0.807068545450704 0.179967956745424 no 618 0.209813496456147 199 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1291 0993-0025 5.79 µM 0.801140264612494 0.181731431155204 no 619 0.21152522424615 227 4353356
SGTC_2152 5568786 200 µM 0.800492083853158 0.181924897747919 no 620 0.211712874109077 247 5399883
SGTC_1871 st057448 67.3 µM 0.799349590771775 0.182266218314673 no 621 0.212043865657403 256 691747
SGTC_1216 1165-0504 9.65 µM 0.799143753358457 0.182327754896605 no 622 0.212103530947516 231 6304004
SGTC_2246 7293507 91.5585 µM 0.79848846423141 0.182523744750407 no 623 0.212293542415104 240 887656
SGTC_1319 1306-0155 43.7 µM 0.793760898172839 0.183941604687402 no 624 0.213667320082365 251 3122360
SGTC_1814 st052110 31.539 µM 0.791495221118223 0.184623535883814 no 625 0.214327531874307 241 674163
SGTC_143 4032-1194 15.74 µM 0.791385515255972 0.184656595381464 no 626 0.214359529936459 239 1806963
SGTC_2568 diosmetin 100 µM 0.790443406289297 0.184940648298442 no 627 0.214634430530081 267 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_266 formosanin C 406 nM 0.790183704689491 0.185018997992502 no 628 0.214710245592579 247 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_265 mycophenolic acid 32.932 µM 0.789993723215372 0.185076326795322 no 629 0.214765717013016 236 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1320 1313-0481 95.3 µM 0.788025528960674 0.185670898192916 no 630 0.215340886691474 225 6813365 YLR208W SEC13
SGTC_1492 4158-0558 28.5 µM 0.78698259033974 0.18598643912338 no 631 0.215646028841072 221 3967268
SGTC_2596 sinensetin 100 µM 0.78695330749817 0.185995303438835 no 632 0.215654600008304 250 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2201 6605497 169.863 µM 0.786658635850021 0.186084519144621 no 633 0.215740862193726 239 670741
SGTC_1242 0402-0103 60.1 µM 0.786563628474127 0.18611328952782 no 634 0.215768678918757 239 432868
SGTC_447 ml7 120 µM 0.785805369719114 0.186343006238794 no 635 0.215990760126844 259 4216 Selective myosin light chain kinase inhibitor.
SGTC_1351 1496-0003 46.5 µM 0.785691710370898 0.186377454803764 no 636 0.216024060442758 246 3891978
SGTC_2739 tacrine 100.86 µM 0.783559643116206 0.187024385611593 no 637 0.216649271946098 219 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1265 0819-1001 68.8 µM 0.783257652455251 0.187116130490781 no 638 0.216737912813048 254 3106768
SGTC_1671 st016596 74.5 µM 0.783092912106744 0.187166190404503 no 639 0.216786276549884 254 2829167
SGTC_1646 st011709 75.6 µM 0.783088278990888 0.187167598396578 no 640 0.216787636809586 238 5757843
SGTC_1151 3909-8316 15.3 µM 0.783005569697564 0.187192734641788 no 641 0.216811920675932 245 800431
SGTC_779 1360-0071 233 µM 0.782829312758092 0.187246307988559 no 642 0.216863675850573 246 7566
SGTC_2162 5663267 200 µM 0.782578688115606 0.187322501742449 no 643 0.216937280269316 242 6456493
SGTC_2828 7998861 71.43 µM 0.782133992697847 0.187457743173862 no 644 0.217067915682182 189 2988188
SGTC_2491 paeonol 100 µM 0.781986473542474 0.187502620245303 no 645 0.217111261507491 251 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2651 TUB2.036 5 µM 0.781831409891571 0.187549799598288 no 646 0.217156829536548 241 15992207 YFL037W TUB2
SGTC_835 0312-0010 67.2 µM 0.780660815155778 0.187906199056961 no 647 0.217501006488461 262 1626196
SGTC_1075 aripiprazole 15.2 µM 0.779752516166997 0.18818302783538 no 648 0.217768280352296 238 60795 An atypical antipschotic. YIL048W NEO1
SGTC_677 0929-0063 136 µM 0.775989521534833 0.189332581496698 no 649 0.2188775864226 282 1539583
SGTC_2191 5911152 200 µM 0.775370433757891 0.189522119270262 no 650 0.219060400344194 240 2875902
SGTC_1793 st048256 72.231 µM 0.774329290377883 0.189841135287216 no 651 0.219368043364702 242 672022
SGTC_2737 bleomycin 30.5 nM 0.773757308683058 0.190016536240746 no 652 0.219537161405162 251 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1049 3226-0134 66 µM 0.773413963293631 0.190121872591804 no 653 0.219638714422812 225 5702385
SGTC_1473 k844-0725 134 µM 0.773210938037558 0.19018417642838 no 654 0.219698776928317 265 54682906
SGTC_359 0081-0058 15.9 µM 0.772361933417119 0.190444852540897 no 655 0.219950046573371 251 3494159
SGTC_153 4077-0274 519.67 µM 0.77212406119121 0.190517927524041 no 656 0.220020476305542 258 3121976
SGTC_1198 1612-1005 86.7 µM 0.771832062079048 0.190607653964907 no 657 0.220106949732441 268 6998509
SGTC_2344 7990960 76.95 µM 0.770657193443234 0.190968933522635 no 658 0.220455075538667 262 140813
SGTC_1235 benzylparaben 21.5 µM 0.769768215075517 0.191242578961262 no 659 0.220718698670005 255 7180
SGTC_2705 st078069 42.8 µM 0.769276474090773 0.191394049938439 no 660 0.22086460010156 226 1530061
SGTC_1129 3453-1384 223 µM 0.767713381266135 0.191876017491265 no 661 0.221328742275945 260 1084452
SGTC_1438 4092-1045 4 µM 0.766458838695041 0.192263382919721 no 662 0.221701667224721 262 1351342
SGTC_2947 9072639 7.68 µM 0.765905315090367 0.192434446515895 no 663 0.221866321565392 265 16488146
SGTC_2048 5246248 200 µM 0.76575507929335 0.192480892160658 no 664 0.221911023624288 238 677046
SGTC_1706 st031321 9.9705 µM 0.764870529102868 0.192754491251585 no 665 0.222174322254897 246 6103185
SGTC_484 loperamide 105 µM 0.761444616541659 0.1938163963799 no 666 0.223195773494022 216 3955 An opioid-receptor agonist.
SGTC_644 1498-1197 63.3 µM 0.757893559073913 0.194920847474062 no 667 0.22425735323511 248 6741615
SGTC_3013 9080133 71.4286 µM 0.755742365249469 0.195591770092226 no 668 0.224901839109317 267 17050193
SGTC_1654 st012436 41.8 µM 0.755306823874093 0.19572777890474 no 669 0.225032452606016 250 4323132
SGTC_1458 k015-0034 6.33 µM 0.754847170573338 0.195871379522074 no 670 0.225170343581259 262 3598957
SGTC_996 3970-0799 1.8 µM 0.752700349362279 0.196542915648649 no 671 0.225814999982648 269 6615648 YGL040C HEM2
SGTC_3114 9122766 49.47 µM 0.75103744584732 0.197064037489191 no 672 0.22631506016504 226 17176985
SGTC_930 2810-3379 265 µM 0.750336411800814 0.197283978357808 no 673 0.226526058972084 267 1015764
SGTC_1165 k072-0275 30.3 µM 0.749249126722617 0.197625394373007 no 674 0.226853532087377 247 6153523 YGL055W OLE1
SGTC_1103 duloxetine 36.1 µM 0.748320307387744 0.197917333571393 no 675 0.227133489199926 249 60835 A selective serotonin reuptake inhibitor.
SGTC_1628 st004252 77.7 µM 0.748289146752247 0.197927132251877 no 676 0.227142884758636 253 692968
SGTC_680 0417-1641 114 µM 0.747852701061166 0.198064406455139 no 677 0.227274504939634 249 2835990
SGTC_3062 9077494 49.47 µM 0.747750416559046 0.198096586064885 no 678 0.227305357386063 219 16459633
SGTC_3009 9080819 71.4286 µM 0.746945055290451 0.198350070116287 no 679 0.227548363862084 238 17027216
SGTC_1660 st012960 28.1 µM 0.744156078039445 0.199229400387267 no 680 0.228391028222736 252 24207266
SGTC_1172 0370-0043 85 µM 0.743752098043388 0.1993569647074 no 681 0.228513232369846 245 376585
SGTC_3074 9116018 49.47 µM 0.742638358804194 0.199708903523234 no 682 0.228850329189188 304 17027303
SGTC_2756 carbadox 75.1 µM 0.740280455666125 0.200455227340681 no 683 0.229564918751008 261 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_722 3534-0461 190 µM 0.738696427976231 0.200957543388818 no 684 0.230045677649951 245 658262
SGTC_231 b-estradiol 524 µM 0.738425740424235 0.201043457465586 no 685 0.230127888758952 256 450 A steroid.
SGTC_973 1325-0077 65.9 µM 0.737398343305369 0.201369745592579 no 686 0.230440071326706 250 2835149
SGTC_3214 9129694 49.47 µM 0.736449947553555 0.20167122545636 no 687 0.230728458729976 267 17158655
SGTC_1887 st057648 70.8 µM 0.73620343106638 0.201749633357958 no 688 0.230803452260135 272 688672
SGTC_2764 methyldopa 94.69 µM 0.733505762613016 0.202608855692851 no 689 0.231625007215172 265 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3158 9100007 49.47 µM 0.731085992127661 0.203381423694104 no 690 0.232363314934489 259 19297233
SGTC_2062 5245942 200 µM 0.730861522867702 0.203453179703866 no 691 0.232431870111159 258 1376160
SGTC_961 1252-1571 372 µM 0.730076449613687 0.203704262550876 no 692 0.232671727855461 273 6813498
SGTC_1957 st077035 62.4 µM 0.729044791686513 0.204034489081486 no 693 0.232987131907463 271 705593
SGTC_27 0485-0001 32.618 µM 0.728797446655353 0.204113709880049 no 694 0.23306278684572 255 2054479
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.726565165230278 0.204829503661106 no 695 0.233746187112229 267 6710655
SGTC_1465 k213-0056 144 µM 0.726408618296311 0.204879757279702 no 696 0.23379415470954 267 24048857 YMR208W ERG12
SGTC_2317 5986382 200 µM 0.726367847879131 0.204892846321422 no 697 0.233806648081788 291 877883
SGTC_2349 9023730 187.07 µM 0.725036227803566 0.205320626388686 no 698 0.234214902800355 265 4126287
SGTC_1088 bifonazole 369 nM 0.72458100859549 0.20546698616836 no 699 0.23435455663837 251 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1387 3342-1166 1.8 µM 0.72390058369133 0.205685868416026 no 700 0.234563385809413 251 3418228
SGTC_2427 5545055 42.75 µM 0.723145273393042 0.205929002149677 no 701 0.23479531854512 261 5372858
SGTC_1981 st071826 47 µM 0.723065309601117 0.205954752401199 no 702 0.234819880403483 240 11838600
SGTC_262 fenpropimorph 62.5 µM 0.722146662817954 0.206250715594405 no 703 0.235102155875061 285 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2245 6637752 200 µM 0.721810532069234 0.206359070812579 no 704 0.235205486638063 249 681890
SGTC_2164 5685496 200 µM 0.721655856624897 0.206408943370368 no 705 0.235253044212884 266 759046
SGTC_1610 st001799 48.1 µM 0.719966567830503 0.206954091589058 no 706 0.235772790038642 261 621897
SGTC_418 lividomycin a 100 µM 0.719878663770374 0.206982482298165 no 707 0.235799852922078 260 72394 An antibiotic.
SGTC_969 1313-0238 134 µM 0.719580822718161 0.207078694289267 no 708 0.235891561505276 275 5212874
SGTC_1819 st053448 58.6 µM 0.71914856627743 0.207218373715583 no 709 0.236024693051148 293 2857616
SGTC_2714 st079313 56.9 µM 0.718625624983202 0.207387431523863 no 710 0.236185810137129 266 2939799
SGTC_2543 pimpinellin 60.67 µM 0.718579239216957 0.207402431169923 no 711 0.236200104416157 257 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2330 7979373 200 µM 0.717053036437307 0.207896313048211 no 712 0.236670686075226 253 1863007
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.716938668344582 0.2079333507111 no 713 0.236705970515123 285 65057 A dermal irritant. YDR527W RBA50
SGTC_1609 st001574 46.4 µM 0.716739193068985 0.207997959327494 no 714 0.236767518846149 278 3960012
SGTC_2249 haloperidol 116.36 µM 0.716216475572542 0.208167319998011 no 715 0.236928845687242 269 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2693 st077581 40.7 µM 0.715428679401654 0.208422719947419 no 716 0.237172098154274 270 25238761
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.714307051446499 0.208786665335295 no 717 0.237518666432016 276 23665772 A membrane-active detergent.
SGTC_2848 9016370 25.97 µM 0.713740181484611 0.208970745444953 no 718 0.237693927474025 249 7894410
SGTC_304 1310-0298 97 µM 0.713276096506039 0.209121519252181 no 719 0.237837462947865 294 1550234
SGTC_1888 azatryptophan 97.5 µM 0.712130444878707 0.209493997317241 no 720 0.238192001582968 237 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3347 9188721 44.724 µM 0.712097011409397 0.209504873175957 no 721 0.238202352405199 271 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_328 k915-0120 63.5 µM 0.71166801932417 0.209644453146118 no 722 0.23833518791237 245 6624543
SGTC_2888 9058547 12.99 µM 0.710995831030039 0.209863271142085 no 723 0.238543409617997 250 16476514
SGTC_1363 1636-0063 10.4 µM 0.710945697899817 0.20987959639812 no 724 0.238558943193213 270 6072185
SGTC_1690 st023502 41.2 µM 0.709963237342809 0.210199673580703 no 725 0.238863466878706 268 24207482
SGTC_893 0958-0369 48.9 µM 0.708610615381225 0.210640814907946 no 726 0.2392830734925 265 6819948
SGTC_1140 3229-1848 2.98 µM 0.708051087109912 0.210823457008395 no 727 0.239456766465733 267 2849525
SGTC_1656 st012921 11 µM 0.708017459595036 0.210834436712682 no 728 0.23946720756455 261 6732821
SGTC_1410 3909-8106 77.9 µM 0.70733047877203 0.211058815897623 no 729 0.239680564520244 280 1039210
SGTC_2251 lansoprazole 556 µM 0.70694742062612 0.211183989718504 no 730 0.239799576661028 264 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3085 9117376 49.47 µM 0.706056758900612 0.211475203800328 no 731 0.240076420488399 264 16480349
SGTC_130 0136-0219 337.655 µM 0.70301292399991 0.212472200770467 no 732 0.241023847670048 301 234244
SGTC_180 1486-1293 102.781 µM 0.700826426684107 0.213190071603695 no 733 0.241705671897525 264 4140536
SGTC_2271 7849410 118.62 µM 0.698872790424589 0.213832684446427 no 734 0.242315766671276 284 972430
SGTC_209 4077-0173 175.592 µM 0.69884881377379 0.213840578126437 no 735 0.242323259442581 251 15993494
SGTC_46 0329-0187a 2.197 µM 0.697413746608019 0.214313345076287 no 736 0.242771950558476 273 46494817
SGTC_3292 9120825 59.784 µM 0.696783478409868 0.214521171926007 no 737 0.242969153559584 271 24824900
SGTC_2240 6690706 185.951 µM 0.696057830663704 0.214760594606798 no 738 0.243196306898308 262 805876
SGTC_1046 2001-0062 216 µM 0.695639147505054 0.214898806955247 no 739 0.243327421708416 280 739778
SGTC_2973 9094665 17.96 µM 0.693795671648571 0.215507974745793 no 740 0.243905178714152 282 25237061 YIL048W NEO1
SGTC_2160 5660466 132.927 µM 0.691739133246553 0.216188728446436 no 741 0.244550583373673 277 2859134
SGTC_1367 1812-0510 76.9 µM 0.689927295187392 0.216789512078237 no 742 0.24511995494242 257 1142582 YDR527W RBA50
SGTC_581 0958-0271 211 µM 0.68966965983388 0.216875019178672 no 743 0.245200974916857 264 4591145
SGTC_2892 9047358 58.44 µM 0.689180441280668 0.217037440530286 no 744 0.245354861728078 268 6466771
SGTC_962 1254-0300 21.5 µM 0.688559762938209 0.217243607874037 no 745 0.245550174734003 247 7340576
SGTC_2174 5790901 200 µM 0.688469119131295 0.217273725996707 no 746 0.245578705214733 282 786020
SGTC_3133 9127736 49.47 µM 0.688366714979231 0.21730775461792 no 747 0.245610939450541 260 27243420
SGTC_875 0709-0210 25.7 µM 0.687803645811516 0.217494915949641 no 748 0.245788219969042 278 6251364
SGTC_573 3702-0553 84.7 µM 0.687585705373016 0.217567383214882 no 749 0.245856856251238 264 1222756
SGTC_395 anisomycin 6.25 µM 0.687331976658949 0.217651767974615 no 750 0.245936776342618 289 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_861 0443-0273 110 µM 0.68726827910267 0.217672955388822 no 751 0.245956842143808 280 6149169
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.686979995229816 0.217768860757496 no 752 0.246047667394598 276 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.686644713041602 0.217880432031411 no 753 0.246153322322808 256 6708561
SGTC_2395 5646831 180.19 µM 0.686206525367066 0.218026296669432 no 754 0.246291441746017 286 6808628
SGTC_2618 avocadyne 43.43 µM 0.683906975261461 0.218792697046616 no 755 0.247016954571876 275 3015189
SGTC_2839 9003951 25.97 µM 0.683866659108136 0.218806147538107 no 756 0.247029684593268 255 2990634
SGTC_299 1273-0059 1.44 µM 0.683735607052657 0.218849873115275 no 757 0.247071067341555 269 2848077
SGTC_953 1188-0045 9.7 µM 0.683074754091703 0.21907044358404 no 758 0.247279803593454 274 6144426
SGTC_656 4090-1979 187 µM 0.681268843489318 0.219673847296874 no 759 0.247850696960807 263 22330961
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.680662838519101 0.219876543645098 no 760 0.248042427780582 276 5024745
SGTC_3198 9112019 49.47 µM 0.680444511773147 0.219949595798878 no 761 0.248111522450268 311 45595555
SGTC_567 1080-0542 68.4 µM 0.67916646856328 0.220377508486406 no 762 0.248516195364999 245 5950415
SGTC_1483 3453-0561 55.9 µM 0.679125191832719 0.220391336655511 no 763 0.248529270872894 292 4546991
SGTC_2267 7931562 200 µM 0.678433280551996 0.22062320875152 no 764 0.248748506828056 261 934880
SGTC_1666 st014829 29 µM 0.678038565313319 0.220755547609282 no 765 0.248873620671439 273 3858230
SGTC_2232 chlorophetanol 41.5365 µM 0.676326107030741 0.221330221309497 no 766 0.24941681039174 280 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_799 1310-0557 151 µM 0.676178239755227 0.221379883304313 no 767 0.249463743250794 291 5354492
SGTC_2859 9028643 45.46 µM 0.674679964872959 0.221883445971364 no 768 0.249939558109638 248 17151580
SGTC_192 3455-0609 60.9 µM 0.673931848092793 0.222135128931409 no 769 0.250177321569973 260 3769639
SGTC_1688 st021091 57.6 µM 0.673512009944153 0.222276443079766 no 770 0.250310805369763 296 3656366
SGTC_1789 tunicamycin 25 nM 0.673059002509429 0.222428979258372 no 771 0.250454877389731 292 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2744 captopril 92.04 µM 0.671203590219475 0.223054354357765 no 772 0.251045420924073 242 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_254 nsc-64875 3.808 µM 0.671175890216268 0.223063698348579 no 773 0.25105424290255 273 56993
SGTC_2021 4019055 173 µM 0.671053435589633 0.223105008411806 no 774 0.251093244577305 290 44827708 YER133W GLC7
SGTC_1150 3909-7983 10.9 µM 0.669826672940967 0.223519097079171 no 775 0.251484144073796 285 23965914
SGTC_2805 7950783 58.44 µM 0.669823541005191 0.223520154810326 no 776 0.251485142455009 279 1178958 YDL195W SEC31
SGTC_705 1124-0212 310 µM 0.668344693963826 0.224019915515789 no 777 0.251956795044511 302 9554485
SGTC_1388 3346-4487 254 µM 0.666756904229458 0.224557198223672 no 778 0.252463712204557 294 3345614
SGTC_1813 st051246 8.6015 µM 0.666167942454488 0.224756679224104 no 779 0.25265188048313 263 5291959
SGTC_1074 carmofur 3.8 µM 0.6658286418439 0.224871645743459 no 780 0.25276031766896 285 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2915 7971052 15.16 µM 0.665688314980086 0.224919202973068 no 781 0.252805171936412 262 5741558
SGTC_1630 st005209 31.3 µM 0.665563230604453 0.224961599279383 no 782 0.25284515760667 279 3367314
SGTC_298 1391-0729 10 µM 0.665064742948327 0.225130602500818 no 783 0.253004542013527 283 3237558
SGTC_2157 5649910 96.377 µM 0.664678768720806 0.225261509474668 no 784 0.253127988139831 286 2858091
SGTC_261 5-fluorouridine 15.376 µM 0.664134159136875 0.225446292505493 no 785 0.253302224481569 258 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_531 3788-1495 174 µM 0.662448135009937 0.226018894899223 no 786 0.253842031809732 280 2896655
SGTC_765 1319-0117 244 µM 0.66154929981043 0.226324490231156 no 787 0.254130054712157 269 3487746 YGL099W LSG1
SGTC_2253 7938677 135.83 µM 0.659401870236567 0.227055539734469 no 788 0.254818870737273 271 2301972
SGTC_2116 5511452 16.8835 µM 0.659042931957719 0.227177862838091 no 789 0.254934100125884 297 870744
SGTC_2789 5281112 71.43 µM 0.658940444123004 0.227212796633795 no 790 0.25496700663718 280 765948
SGTC_23 0213-0011 39.996 µM 0.658730569575613 0.227284343493971 no 791 0.255034399512981 292 627608
SGTC_1732 st034308 51.822 µM 0.657217928094064 0.227800382817048 no 792 0.255520399736452 273 830119
SGTC_1521 st012942 49.4 µM 0.654929018678661 0.228582499102165 no 793 0.256256727894679 264 24207259
SGTC_3075 9116269 49.47 µM 0.653793080966233 0.228971206283021 no 794 0.256622562382283 295 17015205 YNL244C SUI1
SGTC_1421 4029-0249 71.4 µM 0.653071914938044 0.229218174854172 no 795 0.256854958617519 305 2894095
SGTC_1574 spiramycin 23.7 µM 0.652810426540129 0.229307760351626 no 796 0.256939250476978 297 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1068 loratadine 26.9 µM 0.65160742492883 0.229720159520789 no 797 0.257327228325329 299 3957 A H1 histamine antagonist.
SGTC_806 3966-4455 5.86 µM 0.651101376473982 0.229893761265 no 798 0.25749052401562 285 714982
SGTC_983 1491-0821 12.2 µM 0.649703054973077 0.23037384212471 no 799 0.257942025096608 269 46495113
SGTC_2244 6635614 200 µM 0.646645344869043 0.231425585544905 no 800 0.258930751770179 294 836499
SGTC_272 doxorubicin 8.13 µM 0.646384069369843 0.23151557901233 no 801 0.259015327406213 299 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2093 5331342 194.4 µM 0.645809512434707 0.231713547425008 no 802 0.259201363391327 284 33839
SGTC_2921 7974240 10.71 µM 0.644808080543025 0.232058824554357 no 803 0.259525782383959 287 2979074 YDR527W RBA50
SGTC_2967 9089538 49.85 µM 0.644698332712839 0.232096681195482 no 804 0.259561348500392 299 728216
SGTC_3007 9078383 71.4286 µM 0.64424409646014 0.232253402931702 no 805 0.259708580170249 279 6496995
SGTC_3213 9129884 49.47 µM 0.642157737793769 0.232973999496709 no 806 0.2603853851805 286 17190742
SGTC_2516 gossypol 71.55 µM 0.641717445880794 0.233126228148613 no 807 0.260528329827536 294 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_719 2810-4230 27.3 µM 0.64133878591467 0.233257192030421 no 808 0.260651297428871 289 721079
SGTC_3176 9106582 49.47 µM 0.641204234778009 0.233303737910965 no 809 0.260694999313005 257 17018027
SGTC_126 0417-1624 672.48 µM 0.640879967468194 0.233415934337562 no 810 0.260800336044186 307 41912 YDL195W SEC31
SGTC_2614 arthonioic acid 13.39 µM 0.640358835343854 0.233596308643229 no 811 0.26096966925893 291 6710684
SGTC_2819 7996655 46.38 µM 0.639844182256552 0.233774516253259 no 812 0.261136952686728 276 6456960
SGTC_2310 7668677 200 µM 0.639662367458632 0.233837490806475 no 813 0.261196063147783 311 2197143
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.639075686072747 0.234040761674341 no 814 0.261386848115575 286 4330530
SGTC_2866 9034245 58.44 µM 0.638128296718223 0.234369215630422 no 815 0.26169508399953 278 6462273
SGTC_814 3342-0569 96 µM 0.636997980175328 0.234761422802487 no 816 0.262063079627057 300 4346283
SGTC_574 1315-0397 40 µM 0.636385393505395 0.234974135031299 no 817 0.262262629409208 298 6794277
SGTC_1510 1123-0200 71.5 µM 0.636047666144097 0.235091451699336 no 818 0.262372677193505 310 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_295 k015-0027 31 µM 0.635667379882916 0.235223590809266 no 819 0.262496621008301 293 3887424
SGTC_329 k048-0121 21.3 µM 0.635389106162966 0.235320309320632 no 820 0.262587335636427 282 6832902
SGTC_3162 9099653 49.47 µM 0.634970856244648 0.235465720099673 no 821 0.262723711367209 263 25237511
SGTC_2324 6149169 200 µM 0.63481728356665 0.235519124358635 no 822 0.262773794794135 291 2888231
SGTC_715 0868-0130 184 µM 0.632436775060803 0.236347790377606 no 823 0.263550754990013 305 2876258
SGTC_1653 st012112 65 µM 0.631942817944121 0.236519940013021 no 824 0.263712121493393 296 720429
SGTC_2765 myclobutanil 7.74 µM 0.631643737712419 0.236624206381406 no 825 0.263809849869925 321 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2268 7933382 153.85 µM 0.629390313879607 0.237410615142309 no 826 0.264546778848129 283 935025 YOR257W CDC31
SGTC_1143 3454-2408 5.08 µM 0.628804484827078 0.237615294842589 no 827 0.26473853177747 270 X1143
SGTC_364 0083-0097 67.7 µM 0.627912092304525 0.237927269131379 no 828 0.265030764494447 290 5207356
SGTC_2254 7938975 95.19 µM 0.627722754403947 0.237993489226305 no 829 0.265092788243435 304 2969277
SGTC_2143 5623677 140.463 µM 0.626127295681611 0.238551894938318 no 830 0.265615724974159 281 5375313
SGTC_1116 jasmonic acid 1.58368 µM 0.625478766037426 0.238779083187016 no 831 0.265828440232071 316 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2665 lovastatin 100 µM 0.623930952239245 0.239321780231676 no 832 0.266336465957505 297 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3326 9140064 16.379 µM 0.623614988481631 0.239432646720994 no 833 0.266440232399218 314 1868434
SGTC_2546 rhodinyl acetate 100 µM 0.62348001541779 0.239480015098951 no 834 0.266484565471633 283 6708682
SGTC_2118 5526350 200 µM 0.62315127286669 0.239595407683173 no 835 0.266592559420107 301 743594
SGTC_22 0964-0034 14.468 µM 0.62307180832988 0.239623305244367 no 836 0.26661866732962 304 138402
SGTC_3138 9097216 49.47 µM 0.622993454544063 0.239650814590863 no 837 0.266644411569901 296 25237486
SGTC_1913 st060213 96.1 µM 0.622235403662941 0.239917048780382 no 838 0.266893544746023 314 688959
SGTC_360 0957-0399 1.01 µM 0.62169101434437 0.240108342609022 no 839 0.267072530639005 295 6752301 YPR165W RHO1
SGTC_634 1611-4317 11.2 µM 0.621619382532766 0.240133519613733 no 840 0.267096086464223 315 2843522
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.620765591384162 0.240433719170418 no 841 0.267376932892802 297 521171
SGTC_1487 3970-0795 2.82 µM 0.620716114188393 0.240451121997815 no 842 0.26739321250819 290 3765103
SGTC_386 1509-0011 3.07 µM 0.620181359271864 0.240639257419671 no 843 0.267569196262198 290 3107280
SGTC_2934 9036370 36.88 µM 0.619678662408087 0.240816187343221 no 844 0.267734683186269 294 6462800
SGTC_2150 5556613 200 µM 0.617351681158116 0.241636116445599 no 845 0.268501392642602 315 743190
SGTC_94 0334-0113 514.748 µM 0.617233213298701 0.241677899980497 no 846 0.268540455738366 295 6795178
SGTC_2396 5342950 42.78 µM 0.616937846974426 0.241782092563241 no 847 0.268637861031354 292 1886677
SGTC_539 4859-0462 2.54 µM 0.616466595480624 0.241948380358778 no 848 0.268793306122065 289 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2969 9091408 28.7 µM 0.616346887775544 0.241990630804763 no 849 0.268832799610607 302 4286311
SGTC_2403 6032726 181.2 µM 0.615934772003988 0.242136116326674 no 850 0.268968785484251 288 2881040
SGTC_334 1502-1024 68.5 µM 0.61393941898413 0.242841188012598 no 851 0.269627680236783 301 3296216
SGTC_1873 rapamycin 2 nM 0.612922696093029 0.243200880859799 no 852 0.269963727727327 291 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2812 7970281 58.44 µM 0.611337559275149 0.243762239396265 no 853 0.270488065330506 315 2233435
SGTC_1347 1493-0251 600 nM 0.611127399147292 0.243836717741539 no 854 0.270557621084561 286 3986378
SGTC_2960 9079389 5.97 µM 0.610274469952271 0.24413911211557 no 855 0.270840002916511 286 16457355
SGTC_1183 1254-0324 198 µM 0.608959818636908 0.244605599538996 no 856 0.271275536383347 290 5799357
SGTC_1044 1222-0021 1.78 µM 0.608573529630925 0.244742760510389 no 857 0.271403577167658 285 4306703
SGTC_3199 9111318 49.47 µM 0.608175779199464 0.244884034386522 no 858 0.27153544845547 289 8548020
SGTC_260 nsc-65238 3.989 µM 0.60815842612153 0.244890198889984 no 859 0.271541202469754 294 3246252
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.607597472596678 0.245089516867647 no 860 0.271727238751262 301 5106787 A p450 inhibitor.
SGTC_591 4299-0174 154 µM 0.606865936483966 0.245349577276296 no 861 0.271969942817918 307 5509088
SGTC_2478 5763493 32.33 µM 0.605385453060557 0.245876341251027 no 862 0.272461457190259 307 1365576 YLR208W SEC13
SGTC_3070 9117005 49.47 µM 0.605363880236435 0.245884021462294 no 863 0.272468622538071 307 8779016
SGTC_1958 st076513 41.9 µM 0.605265870025162 0.245918916017534 no 864 0.272501177509447 311 732122 YGL099W LSG1
SGTC_597 k018-0003 82.8 µM 0.603972420913235 0.246379671288789 no 865 0.272930989089404 318 6786234
SGTC_150 3970-0969 77.2 µM 0.603333279173795 0.246607518444439 no 866 0.273143499147303 318 6615640
SGTC_3350 9150499 3.57 µM 0.601895955386881 0.247120320934304 no 867 0.273621698358566 304 4910996 YPR165W RHO1
SGTC_3041 9091929 49.47 µM 0.600001861404044 0.247796958111389 no 868 0.274252497484796 305 25236887
SGTC_761 k216-0224 480 µM 0.59981028858377 0.247865449717553 no 869 0.274316337859036 340 1340404
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.597898480837841 0.248549517388406 no 870 0.274953836802257 284 6312947
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.597853101706602 0.248565766795931 no 871 0.274968977496032 310 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1635 st007035 42.4 µM 0.596488311896916 0.249054736541061 no 872 0.27542452987417 290 3716403
SGTC_2075 5212009 200 µM 0.596230970805742 0.249146992670265 no 873 0.275510469193847 318 780898
SGTC_374 0880-0231 82.3 µM 0.596154561062969 0.249174388868842 no 874 0.27553598884454 308 6833587
SGTC_2112 5488546 200 µM 0.595141417544301 0.249537796065911 no 875 0.275874472683023 325 600757
SGTC_1675 st018485 24.5 µM 0.594728131385342 0.249686119624747 no 876 0.27601260720415 301 3323024
SGTC_2898 9056270 58.44 µM 0.594722761723884 0.249688047041393 no 877 0.276014402154123 278 19154699
SGTC_1824 st053723 68.6 µM 0.594397717767156 0.249804734872106 no 878 0.276123067283881 311 675225
SGTC_2492 derrusnin 100 µM 0.59381614354674 0.250013586961491 no 879 0.276317545184499 320 1715307 Part of coumarin class of compounds.
SGTC_2827 7993847 71.43 µM 0.5932288415074 0.25022458998524 no 880 0.276514006632335 284 2985692
SGTC_1155 4088-0394 48.2 µM 0.592843988837695 0.250362909182531 no 881 0.276642782824468 310 2326248
SGTC_852 0418-0143 439 µM 0.591937288983456 0.250688944689568 no 882 0.276946291314519 293 5369229
SGTC_2124 5246320 200 µM 0.591754629082845 0.250754653619998 no 883 0.277007454569685 314 579342
SGTC_3253 9135987 49.47 µM 0.59023948443111 0.251300053669172 no 884 0.277515052083082 300 4182430
SGTC_3109 9122853 49.47 µM 0.58946791796844 0.251578031925116 no 885 0.277773713664445 346 1234709
SGTC_2787 5284540 71.43 µM 0.586873205900458 0.252514039444088 no 886 0.278644433103477 321 736958
SGTC_698 k064-0052 127 µM 0.586065025194992 0.252805954097875 no 887 0.278915909206207 327 5088751
SGTC_878 0828-0289 13.7 µM 0.584870014975572 0.2532379168216 no 888 0.279317560922331 319 745350 YLR208W SEC13
SGTC_87 0100-0052 35.5 µM 0.583128225599539 0.253868219307327 no 889 0.279903491982605 318 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2199 6590217 200 µM 0.582048244423001 0.254259445988735 no 890 0.280267092505257 306 703109
SGTC_1359 1582-0056 520 nM 0.578790643865792 0.255441434364013 no 891 0.281365222476528 319 3661189
SGTC_1937 st074714 47.2 µM 0.577833339874635 0.255789327772804 no 892 0.281688321888391 307 17250970
SGTC_1560 lithocholic acid 53.1 µM 0.575632149597388 0.256590198534276 no 893 0.282431922836437 305 9903 A bile acid which acts as a detergent.
SGTC_540 1187-0821 17.3 µM 0.575524494914536 0.25662940058008 no 894 0.282468314691498 318 847520
SGTC_1626 st003712 1.76 µM 0.575179919398127 0.256754897416817 no 895 0.282584811008013 319 24207035
SGTC_1227 3909-8010 46.6 µM 0.574692235566134 0.256932569902833 no 896 0.282749729773814 297 15982272
SGTC_347 4534-1311 26.2 µM 0.574320192515375 0.257068155257866 no 897 0.282875573685564 302 2862016
SGTC_3055 9094636 49.47 µM 0.572353405282788 0.257785538410248 no 898 0.283541287892791 307 25236176
SGTC_1657 st012939 43.4 µM 0.57220296463326 0.257840454193918 no 899 0.283592239635164 293 24207257
SGTC_2222 6885208 172.143 µM 0.571508863654099 0.258093902471786 no 900 0.283827376867961 303 609514
SGTC_871 0574-0004 149 µM 0.571121354007011 0.25823545628982 no 901 0.28395869222422 313 9551173
SGTC_297 0986-0032 24 µM 0.570189209462357 0.258576125133175 no 902 0.284274686977716 317 2847425
SGTC_320 4092-0846 5.34 µM 0.569668606473516 0.258766490010352 no 903 0.284451243261316 314 1359356
SGTC_1101 ebselen 5.29 µM 0.56963446495769 0.258778976808817 no 904 0.284462823778667 325 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1999 st074831 12.5 µM 0.568714423085774 0.25911558709144 no 905 0.28477497908824 333 17112523
SGTC_3008 9078912 71.4286 µM 0.56720027825427 0.259670050746152 no 906 0.285289059510579 318 16648731
SGTC_1488 4013-0813 75.9 µM 0.566364264492904 0.259976452262571 no 907 0.285573091096318 302 2910057
SGTC_1201 1889-3372 45.9 µM 0.565771041354077 0.26019398333627 no 908 0.285774717355034 294 5392199
SGTC_2172 5754775 163.918 µM 0.562130364164506 0.261531047512395 no 909 0.287013600888791 304 2263357
SGTC_1370 2001-0092 44.6 µM 0.56138507897194 0.261805193008713 no 910 0.287267526799926 319 790957
SGTC_918 glabranin 770.725 nM 0.559692182405266 0.262428454838169 no 911 0.287844707790344 314 124049 Also referred to as licorice root.
SGTC_1016 4226-1401 38 µM 0.558092359508859 0.263018147791169 no 912 0.288390658840802 317 2901613
SGTC_745 0469-0705 296 µM 0.55651115847086 0.263601641502383 no 913 0.288930734239794 336 3486736
SGTC_2114 5491910 81.25 µM 0.556224939121241 0.263707332520906 no 914 0.289028546236493 341 2849228
SGTC_2586 curcumin 80 µM 0.555642921203168 0.263922318480613 no 915 0.289227491837188 314 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_507 nimesulide 162 µM 0.555428902393035 0.264001395275186 no 916 0.289300664017607 323 4495 A COX2 inhibitor.
SGTC_3001 9076041 71.4286 µM 0.552899770324913 0.264936785814105 no 917 0.290166022362815 314 16004211
SGTC_3105 9121040 49.47 µM 0.552339589430135 0.265144194335542 no 918 0.290357855700155 283 41448907
SGTC_2886 9058944 51.95 µM 0.549067500519652 0.2663573396393 no 919 0.291479563729974 292 4949929
SGTC_269 exalamide 29 µM 0.548070006282427 0.266727724054833 no 920 0.291821917278509 313 3316 A derivative of salicylamide.
SGTC_2443 5493264 126.67 µM 0.547893126361557 0.266793429358177 no 921 0.291882644414953 343 5340055
SGTC_48 0382-0018 55 µM 0.547353075227875 0.266994091893531 no 922 0.292068093385925 290 762596
SGTC_1246 0422-0085 105 µM 0.547291247975216 0.267017069419278 no 923 0.29208932783759 354 264295
SGTC_2522 biochanin a 4.94 µM 0.54694173368323 0.267146981944733 no 924 0.292209381363125 329 5280373 A possible chelator.
SGTC_934 2950-0684 338 µM 0.546921132703425 0.267154640210397 no 925 0.292216458242954 344 1121253
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.545243583316246 0.267778628798045 no 926 0.292792999973428 320 4213774
SGTC_363 0455-0021 3.06 µM 0.54511435098004 0.267826729067082 no 927 0.292837436564508 320 4597466
SGTC_1237 0330-0133 46.1 µM 0.544928551323192 0.267895891316468 no 928 0.292901329337366 344 X1237 YHR072W ERG7
SGTC_3188 9110789 49.47 µM 0.544923234388615 0.267897870629875 no 929 0.292903157819673 328 849217
SGTC_1325 1431-0015 227 µM 0.543802848796907 0.26831511620279 no 930 0.293288574121218 312 1103340
SGTC_1805 st050013 60.3 µM 0.543057420339729 0.268592904038454 no 931 0.293545134096303 324 4037144
SGTC_3172 9105863 49.47 µM 0.542684587414452 0.268731896394545 no 932 0.293673493914139 317 2348785
SGTC_59 0330-0160 1.33 µM 0.542607525441026 0.268760629653625 no 933 0.293700028235565 328 4293482
SGTC_3090 9117696 49.47 µM 0.541075322066599 0.269332245833664 no 934 0.294227833514541 319 7923821
SGTC_621 3584-0052 32.1 µM 0.541065444289951 0.269335932893682 no 935 0.294231237579651 339 2273927
SGTC_3164 9100705 49.47 µM 0.541048190540113 0.269342373230732 no 936 0.294237183585621 308 17174235
SGTC_1735 st034310 56.75 µM 0.539341527192768 0.269979803751802 no 937 0.294825609848733 310 871153
SGTC_2607 solasodine 47.35 µM 0.538105556135839 0.27044190384534 no 938 0.295252088417021 319 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1301 naphtanilide LB 4.81 µM 0.538024315398864 0.270472291657131 no 939 0.295280130920408 320 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2153 5569715 200 µM 0.536868461704173 0.270904819397027 no 940 0.295679238736621 338 2054701
SGTC_426 0988-0037 14.6 µM 0.536286888747982 0.271122578113573 no 941 0.295880145328322 327 5383008
SGTC_1330 1469-0054 61.8 µM 0.535194979527878 0.271531657996145 no 942 0.296257518777377 344 7102664
SGTC_3122 9126309 49.47 µM 0.53380765569109 0.272051856937219 no 943 0.296737308271277 348 17591206
SGTC_1997 st073024 93.8 µM 0.532185366211606 0.27266078783279 no 944 0.297298808643677 322 686268
SGTC_659 k018-0002 107 µM 0.532151675465328 0.272673440914823 no 945 0.29731047469477 336 6797879 YHR007C ERG11
SGTC_2295 7971645 200 µM 0.531744830710398 0.272826260771913 no 946 0.297451368811771 348 2978226 YKL099C UTP11
SGTC_1405 3909-7894 12 µM 0.531097610385233 0.273069458509515 no 947 0.297675570035195 332 7104060
SGTC_2404 5161160 200 µM 0.529114882108846 0.273815151197009 no 948 0.298362879140153 336 2831543
SGTC_1874 staurosporine 7.6 µM 0.528464154085569 0.274060105546874 no 949 0.298588610145555 324 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2991 9074669 71.4286 µM 0.528158782088815 0.274175094420362 no 950 0.298694567389661 340 17333109
SGTC_2419 paclitaxel 166.5 µM 0.524267877911599 0.275642310530701 no 951 0.300046117742786 342 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1567 st069303 68.4 µM 0.524195246522446 0.275669735668488 no 952 0.300071373377482 346 5581319
SGTC_2151 5563267 85.4165 µM 0.523995129652566 0.275745305429389 no 953 0.300140963673165 366 5310824
SGTC_2 0422-0095 29 µM 0.523305149528246 0.276005939384389 no 954 0.300380959013983 295 6790840
SGTC_2003 4023581 200 µM 0.520757867174516 0.276969199454504 no 955 0.301267728571303 334 16641307
SGTC_1616 st002734 56.1 µM 0.520329125479017 0.277131490683895 no 956 0.30141709959827 334 4026101
SGTC_2483 5729050 27.16 µM 0.519705206959799 0.277367745125955 no 957 0.30163452858731 341 2865180
SGTC_535 2293-4129 48.2 µM 0.517120002825301 0.27834771261514 no 958 0.302536195523376 355 396118 YIL048W NEO1
SGTC_2616 abietic acid 100 µM 0.51672333850151 0.278498224462051 no 959 0.302674650867176 337 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2584 androsterone 48.74 µM 0.516517659513757 0.278576283700059 no 960 0.302746454116984 303 2754130 A steroid.
SGTC_2636 apigenin dimethyl ether 100 µM 0.515809686819101 0.278845054758557 no 961 0.302993668154196 345 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_141 0443-0274 32.331 µM 0.515385558377946 0.27900612908472 no 962 0.303141811053487 300 1627241
SGTC_3314 9135860 59.4275 µM 0.514104091948062 0.279493075604502 no 963 0.303589608341766 338 25252478
SGTC_155 k072-0202 43.6 µM 0.513942723736527 0.279554423418473 no 964 0.303646017990232 345 5857737
SGTC_115 0527-0192 112.043 µM 0.512646819376623 0.280047328005609 no 965 0.304099198141716 351 4233931
SGTC_651 3253-0966 34.4 µM 0.512216471199766 0.280211106506164 no 966 0.304249758335094 340 781462
SGTC_533 1222-0222 6.71 µM 0.508954268608799 0.281454116534122 no 967 0.30539213974272 358 3982874
SGTC_2978 9011784 42.97 µM 0.506907072783487 0.282235523982056 no 968 0.306110011397822 338 2994934
SGTC_1738 st035555 74 µM 0.50620100216846 0.28250527059276 no 969 0.306357775776529 369 5331140
SGTC_2701 st077767 14.721 µM 0.505937939202144 0.282605802629307 no 970 0.306450108787779 339 5721188
SGTC_3076 9116187 49.47 µM 0.504980181527653 0.28297196411815 no 971 0.306786377911923 356 27241210
SGTC_3132 9126706 49.47 µM 0.503511841072855 0.283533768993033 no 972 0.307302228661982 362 850858
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.503433490279502 0.283563761972295 no 973 0.307329765239118 305 3256 An antibiotic and ribosome inhibitor.
SGTC_1756 st041558 35.5 µM 0.503296778198952 0.283616099512677 no 974 0.307377815633809 350 3955792
SGTC_482 fipronil 114 µM 0.501511651570305 0.284299924633928 no 975 0.308005539899125 341 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_84 0443-0269 128.823 µM 0.499501474487509 0.285070901498517 no 976 0.308713074142484 329 6150058
SGTC_2811 7967822 32.47 µM 0.498610221492754 0.285413048459522 no 977 0.309027001434225 320 2232244
SGTC_2284 7945075 39.21 µM 0.497637099524136 0.285786847627936 no 978 0.309369924894382 353 1245402
SGTC_3337 9144342 33.5465 µM 0.497279718605624 0.285924184525321 no 979 0.309495905911775 309 17682949
SGTC_2694 st077685 81.9 µM 0.497268861799072 0.285928357147643 no 980 0.309499733415501 306 2838096
SGTC_1164 k060-0068 93.7 µM 0.496314369230682 0.286295312643728 no 981 0.3098363149229 330 5963676
SGTC_1508 1080-0625 72.9 µM 0.494492505251698 0.286996349874693 no 982 0.310479199049075 334 767111
SGTC_1757 st041620 31.8375 µM 0.494333758973256 0.287057472536377 no 983 0.310535243575415 348 5289815
SGTC_2810 7959871 45.46 µM 0.492566197069069 0.287738459482933 no 984 0.311159568751809 345 2974535
SGTC_631 k072-0230 41.5 µM 0.492471888205268 0.287774815210838 no 985 0.311192895127419 330 5773147
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.492020443982019 0.28794887538511 no 986 0.311352445572931 340 688751
SGTC_2769 toremifene 3.73 µM 0.491901716607258 0.287994660517905 no 987 0.311394412359544 322 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1482 3346-2049 8.48 µM 0.490184773740284 0.288657153342697 no 988 0.312001577142126 320 3826804
SGTC_1684 st024538 14.6195 µM 0.489147791657109 0.28905762653681 no 989 0.312368534198665 333 6732859
SGTC_2026 5148700 152 µM 0.489096257258722 0.289077535474336 no 990 0.312386775545177 323 79838
SGTC_405 ebelactone b 50 µM 0.489042149128482 0.289098439398383 no 991 0.312405928396146 328 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3329 9141233 27.5565 µM 0.488230237270148 0.289412195591705 no 992 0.312693384615075 337 4909101 YNL103W MET4
SGTC_3285 9112818 20.8695 µM 0.488001716991199 0.289500534082347 no 993 0.312774312448818 340 17017947 YPR165W RHO1
SGTC_1096 rimcazole 32.2 µM 0.486864808641005 0.289940213895843 no 994 0.313177069575397 361 18528119 A dopamine reuptake inhibitor.
SGTC_3034 9090421 49.47 µM 0.486369342443035 0.290131924871307 no 995 0.313352661466746 350 17173761
SGTC_2258 7960471 200 µM 0.483493832790198 0.291245718248813 no 996 0.314372568837357 354 2974708
SGTC_3120 9124077 49.47 µM 0.483185883016406 0.291365117042585 no 997 0.314481879008965 371 18774327 YGL155W CDC43
SGTC_1472 k841-0093 193 µM 0.482290703163615 0.29171232728378 no 998 0.314799725318405 354 X1472
SGTC_870 0573-2213 57.6 µM 0.482029659651718 0.291813613609967 no 999 0.314892438378665 327 3916321
SGTC_3333 9141820 12.094 µM 0.481586575537459 0.29198557019328 no 1000 0.315049832274754 362 1939433
SGTC_2101 5377231 179.231 µM 0.480677230194356 0.292338625863576 no 1001 0.315372958301811 364 2844213
SGTC_43 0570-0105 72.5 µM 0.480355878912033 0.292463438782979 no 1002 0.31548718079559 343 1114046 YDL195W SEC31
SGTC_73 0327-0325 16.231 µM 0.480100570598847 0.292562618250326 no 1003 0.315577941260011 313 53298
SGTC_1758 st042942 75.2445 µM 0.479575719279504 0.292766556000783 no 1004 0.315764557470304 344 669317
SGTC_2962 9082311 13.18 µM 0.478203079131621 0.293300224858504 no 1005 0.316252835588338 361 16459453
SGTC_122 0236-0016 402.397 µM 0.477508314925117 0.293570514027551 no 1006 0.316500100662138 364 6808838
SGTC_1812 st052057 4.327 µM 0.476026612323785 0.294147336490151 no 1007 0.317027709357024 329 3645418
SGTC_2071 5230951 39.92 µM 0.47303290552396 0.295314372907603 no 1008 0.31809485160938 365 1799272
SGTC_595 3909-8003 73.7 µM 0.472395074127451 0.29556329373866 no 1009 0.318322409842449 356 699517
SGTC_1640 st009078 66.4 µM 0.472033127524174 0.295704590335424 no 1010 0.318451571538891 364 690618
SGTC_998 3996-0085 177 µM 0.471900265074441 0.295756464922663 no 1011 0.318498989428032 345 715391
SGTC_323 4013-0906 34.3 µM 0.471736274683265 0.295820498814709 no 1012 0.318557520810436 336 2910086
SGTC_1895 st058434 18.3 µM 0.471654932676774 0.295852263070411 no 1013 0.318586555045798 376 5393175
SGTC_2914 7968218 45.32 µM 0.471502668590012 0.295911726785181 no 1014 0.318640907219629 352 2977111
SGTC_290 2043-6722 48.1 µM 0.470793718050288 0.29618866557572 no 1015 0.318894025503322 340 773758 YLR208W SEC13
SGTC_3110 9122132 49.47 µM 0.470002176082924 0.296498007630924 no 1016 0.319176731431023 328 918317
SGTC_935 2996-0153 430 µM 0.469767965772756 0.296589567601876 no 1017 0.319260401804015 356 23738523
SGTC_1540 guanosine 70.6 µM 0.469340246168089 0.296756809688552 no 1018 0.319413226086859 365 6802 Guanosine is a purine nucleoside
SGTC_2487 5918373 44.05 µM 0.468576275327796 0.297055636311355 no 1019 0.319686269319494 364 2876279
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.468332915658698 0.297150855155992 no 1020 0.319773266619141 371 1273210
SGTC_1647 st011722 22.4 µM 0.468259133706026 0.297179726427402 no 1021 0.31979964447965 340 2854783
SGTC_3174 9107204 49.47 µM 0.468200990307761 0.297202479152476 no 1022 0.319820432026833 352 3938802
SGTC_1199 1638-0010 4.46 µM 0.467542112979821 0.297460367216345 no 1023 0.320056034730322 345 3111136
SGTC_235 0330-0087 5 mM 0.466781687340092 0.297758128786266 no 1024 0.320328039514835 350 46494818 YHR062C RPP1
SGTC_2390 9097792 176.6 µM 0.46615597330111 0.298003242955321 no 1025 0.320551930291597 341 4497149
SGTC_1314 1222-0010 41.1 µM 0.465687310180693 0.298186894977429 no 1026 0.320719668450987 337 3526027
SGTC_1452 4194-0072 190 µM 0.465496619889572 0.298261634314752 no 1027 0.320787928463458 350 1343545
SGTC_2017 5132927 60.65 µM 0.463350783803729 0.299103262785299 no 1028 0.321556475039771 345 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_148 3253-0744 288.01 µM 0.462843153477589 0.299302520440852 no 1029 0.321738398406305 346 6893655
SGTC_3319 9138450 16.7555 µM 0.461833356953269 0.299699069860587 no 1030 0.322100413979488 364 2029690
SGTC_813 k007-0158 173 µM 0.460951265308052 0.300045663895455 no 1031 0.322416785102898 353 6523916
SGTC_2037 5169046 200 µM 0.459575501421522 0.300586594708232 no 1032 0.322910473539601 332 5718022
SGTC_3096 9117468 49.47 µM 0.459226158776266 0.300724021338388 no 1033 0.32303588376079 347 41316311
SGTC_2373 9071805 200 µM 0.458060684710635 0.301182707881256 no 1034 0.323454421780956 356 10149009
SGTC_2286 7945697 125 µM 0.45684732421906 0.30166057529954 no 1035 0.323890393941814 346 1245733
SGTC_2907 7721985 69.9 µM 0.455976301164113 0.302003827337177 no 1036 0.324203510031832 331 3267881
SGTC_760 0568-0725 82.9 µM 0.455478098480851 0.30220023746546 no 1037 0.324382660276058 367 3916171
SGTC_943 3253-1379 105 µM 0.454748232567481 0.302488081368319 no 1038 0.32464518841951 371 668464
SGTC_982 1491-0518 27.5 µM 0.4529128711582 0.303212452239833 no 1039 0.325305741156507 347 3091256
SGTC_3006 9075424 71.4286 µM 0.45119797906808 0.303889976948841 no 1040 0.325923433033384 357 7465181
SGTC_394 menadione 8.33 µM 0.446938492898096 0.30557574121895 no 1041 0.327459735077388 366 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_546 peri-Naphthalide 147 µM 0.446398772176477 0.305789640420317 no 1042 0.327654609788904 335 223824 A penicillin ester.
SGTC_3244 9134489 49.47 µM 0.445679393783638 0.306074843608121 no 1043 0.327914425743542 378 16584271
SGTC_1007 4101-0031 70 µM 0.4451076252544 0.306301609599082 no 1044 0.328120989271603 382 1146276
SGTC_2951 9072950 58.06 µM 0.444972826320994 0.306355082281549 no 1045 0.328169695910881 361 16488155
SGTC_2716 st080858 38.6235 µM 0.442476187633535 0.307346205423031 no 1046 0.32907232897637 345 5296050
SGTC_2480 5767542 37.17 µM 0.442232517653822 0.307443013825681 no 1047 0.329160478768066 372 2867358
SGTC_1269 0831-0796 3.05 µM 0.441903314544598 0.307573825255417 no 1048 0.32927958601899 363 927758
SGTC_2057 5236571 38.335 µM 0.44189965012276 0.307575281479837 no 1049 0.329280911921778 362 54684039 YBR257W POP4
SGTC_889 0919-1524 82.7 µM 0.4416145744898 0.307688578520404 no 1050 0.329384067809262 350 3905452
SGTC_3356 9151811 4.48 µM 0.441590017939638 0.307698338839402 no 1051 0.329392954313965 362 1859254 YPR165W RHO1
SGTC_1311 1190-0148 100 µM 0.441432269603832 0.307761041204275 no 1052 0.329450042453018 370 1961333
SGTC_1157 4092-0394 27.6 µM 0.440755976946133 0.308029920013397 no 1053 0.32969483359043 336 3659885
SGTC_1294 1000-1494 117 µM 0.439931695964241 0.308357775040752 no 1054 0.32999328930623 364 712797 YDL207W GLE1
SGTC_562 3772-2733 112 µM 0.439689831237752 0.30845400496182 no 1055 0.33008088425198 378 2876874 YIL048W NEO1
SGTC_3020 9089140 49.47 µM 0.43927279060915 0.308619962449085 no 1056 0.330231943661109 347 17217859
SGTC_1073 triclabendazole 3.09 µM 0.438741739620469 0.308831345904548 no 1057 0.330424339672733 350 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_864 0469-0573 172 µM 0.433922069075155 0.310752692362766 no 1058 0.332172516604991 369 689425
SGTC_2044 5102272 200 µM 0.433010742855869 0.311116572725823 no 1059 0.332503482653796 342 592666
SGTC_3026 9090633 49.47 µM 0.431901046928982 0.311559908835986 no 1060 0.332906666919161 347 25236842
SGTC_1094 duloxetine 25.4 µM 0.431601747763056 0.311679529076541 no 1061 0.33301544397815 334 60834 A selective serotonin reuptake inhibitor.
SGTC_3044 9093193 49.47 µM 0.431450022842995 0.311740176234316 no 1062 0.333070592134535 373 25236277
SGTC_49 0717-0965 32.132 µM 0.430187384363542 0.312245073293153 no 1063 0.333529669100039 381 5889349 YGL099W LSG1
SGTC_2583 asiatic acid 100 µM 0.430002499877861 0.312319033537211 no 1064 0.333596911356369 388 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_738 1315-0003 72.4 µM 0.429951752487882 0.312339335586465 no 1065 0.333615369053826 380 6251474
SGTC_1563 conessine 56.1 µM 0.429888171895529 0.312364772502958 no 1066 0.333638494975801 387 441082 An anti-amoebic, histamine inhibitor.
SGTC_709 3807-1509 243 µM 0.428386120857302 0.31296596334824 no 1067 0.33418501385727 389 1886677 YPL242C IQG1
SGTC_613 3914-0030 117 µM 0.428327432340917 0.312989463340984 no 1068 0.334206374728006 368 1145395
SGTC_2996 9066192 71.4286 µM 0.428310011900706 0.312996438961199 no 1069 0.334212715352375 341 6472854
SGTC_133 0724-0033 378.92 µM 0.42797020473072 0.313132520422097 no 1070 0.334336406510233 360 280309
SGTC_3313 9133968 57.047 µM 0.426585405892393 0.31368734935135 no 1071 0.334840664693358 360 1494643
SGTC_456 gingerol 170 µM 0.426273279568974 0.31381246312996 no 1072 0.334954362994598 376 442793 A herb.
SGTC_2933 9026794 32.47 µM 0.425590937580935 0.314086049972396 no 1073 0.335202972484382 396 17586027
SGTC_808 0711-0032 135 µM 0.423681507829864 0.314852183728343 no 1074 0.335899051580881 389 4252555
SGTC_635 k038-0028 24.7 µM 0.423130022544807 0.315073608575433 no 1075 0.336100199467543 390 4035102
SGTC_3232 9132874 49.47 µM 0.42297291659509 0.315136699781043 no 1076 0.336157510641329 362 3784940
SGTC_1809 st050081 57.6 µM 0.419658726008143 0.316468879518255 no 1077 0.33736739043031 388 5036894
SGTC_936 3005-4620 401 µM 0.41964419261228 0.316474726659779 no 1078 0.337372699714157 398 777207
SGTC_775 4577-0580 57.3 µM 0.419500716166926 0.316532453213494 no 1079 0.33742511571067 380 2006902
SGTC_2863 9028737 58.44 µM 0.419265050375158 0.316627281083014 no 1080 0.337511217924918 395 6460917
SGTC_2545 solidagenone 89.61 µM 0.418276609145592 0.317025144105571 no 1081 0.337872444761067 358 6708572 An anti ulcer agent
SGTC_3226 9131256 49.47 µM 0.41822687716329 0.317045167600396 no 1082 0.337890623313103 347 17178073
SGTC_2260 7964312 200 µM 0.418034976391185 0.317122437270371 no 1083 0.337960772425676 358 231951
SGTC_3086 9117350 49.47 µM 0.417103508466478 0.317497610070903 no 1084 0.338301349397819 351 2679265
SGTC_204 PMA1.184 62.41 µM 0.41642097157099 0.317772638546614 no 1085 0.338550992586555 360 2252213 YGL008C PMA1
SGTC_2304 7443016 91.4 µM 0.415000203360078 0.318345460020142 no 1086 0.339070877126768 363 939854
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.412906242182833 0.319190489655567 no 1087 0.339837653755194 353 803109
SGTC_50 0929-0078 56.389 µM 0.411688304234009 0.319682428090402 no 1088 0.34028394930335 375 1377751
SGTC_1983 st071813 46.9 µM 0.411349033911571 0.319819519638276 no 1089 0.340408309834501 372 11838595
SGTC_763 3453-1109 128 µM 0.410023351904039 0.320355433953913 no 1090 0.340894408763141 369 1560353
SGTC_3229 9132204 49.47 µM 0.409732637227054 0.320473007132031 no 1091 0.341001042908498 381 17682924
SGTC_1782 st039423 80.636 µM 0.409575288598558 0.320536650851964 no 1092 0.341058763685102 364 2068169
SGTC_1305 1181-0477 144 µM 0.409438027224643 0.320592174072282 no 1093 0.341109118818171 360 6252086
SGTC_92 0063-0024 660.874 µM 0.409314463282507 0.320642160016031 no 1094 0.341154451389289 378 3594437
SGTC_948 3448-0295 75.3 µM 0.409276868385734 0.320657369114356 no 1095 0.34116824448716 355 678569
SGTC_1354 1498-1681 81 µM 0.408378967349975 0.321020706376792 no 1096 0.341497736186738 366 5754243
SGTC_1947 st076332 61.6 µM 0.407006644273088 0.321576350539541 no 1097 0.3420015541147 391 24208416
SGTC_3018 9082602 49.47 µM 0.402980022149011 0.323209003714819 no 1098 0.343481460664765 368 17332089
SGTC_856 0433-0016 11.3 µM 0.402592271853888 0.323366403321602 no 1099 0.343624097913417 375 3911780
SGTC_2844 9010103 25.97 µM 0.401609763587403 0.323765374740227 no 1100 0.343985621604983 389 2480525
SGTC_1486 3970-0793 4.53 µM 0.399988372989555 0.324424222802941 no 1101 0.344582540280401 397 2844330
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.399838370234695 0.324485203876671 no 1102 0.344637783729955 346 2724 A muscle relaxant with antifungal properties.
SGTC_590 k048-0076 22.4 µM 0.398256218389085 0.325128687204678 no 1103 0.345220664779918 385 6832814
SGTC_1861 st057647 17.4 µM 0.397928150805558 0.325262182280174 no 1104 0.345341574288615 414 688668
SGTC_2074 5212007 75.395 µM 0.3973971922624 0.325478283909681 no 1105 0.345537292827643 395 758611
SGTC_2873 9040596 71.43 µM 0.396346075669346 0.325906264360917 no 1106 0.345924870464212 404 6463863
SGTC_582 0987-0078 156 µM 0.396101660569103 0.326005815137469 no 1107 0.346015016664339 380 1625765
SGTC_428 3448-4153 16.5 µM 0.39329789959143 0.327148678509792 no 1108 0.347049734693782 352 3834874
SGTC_564 3555-0129 330 µM 0.393204692665709 0.327186699253177 no 1109 0.347084152023375 382 563260
SGTC_3160 9100216 49.47 µM 0.389029781767399 0.32889155287086 no 1110 0.348627057823006 378 17191039
SGTC_195 4234-0266 16.654 µM 0.387735721276988 0.329420717079078 no 1111 0.349105809023242 382 2303354
SGTC_2379 9035213 200 µM 0.38693778213616 0.329747178935436 no 1112 0.349401134746705 401 646551
SGTC_3322 9139058 2.11 µM 0.384789777488054 0.330626639018056 no 1113 0.350196586737071 347 4908926 YPR165W RHO1
SGTC_375 3970-0961 9.27 µM 0.3845150562537 0.330739186065316 no 1114 0.350298369382604 367 2898222
SGTC_2502 avocadyne acetate 18.59 µM 0.382735522970406 0.331468590661381 no 1115 0.350957936397278 344 3952079
SGTC_2733 amorolfine 100 µM 0.380209802653318 0.33250494418061 no 1116 0.351894841611703 404 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_473 2-arachidonoylglycerol 10 µM 0.379895773193036 0.332633886482398 no 1117 0.352011392525582 367 5282280 An endocannabinoid.
SGTC_2619 obliquin 87.91 µM 0.379209124828601 0.33291589722105 no 1118 0.352266288046225 396 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3206 9114350 49.47 µM 0.377594730710077 0.333579311090377 no 1119 0.352865839843027 395 17087243
SGTC_1737 st035557 69.7 µM 0.37740219440035 0.333658466131097 no 1120 0.352937368179017 371 5716916
SGTC_2281 7943571 200 µM 0.376711772633965 0.333942371444364 no 1121 0.353193906520224 409 1244024
SGTC_2824 7998404 51.95 µM 0.376269060808768 0.334124467073255 no 1122 0.353358438999605 390 837851
SGTC_60 0986-0278 202 µM 0.374607676750231 0.334808173292574 no 1123 0.353976131454496 412 3110598
SGTC_296 1222-0039 74.9 µM 0.374310204044464 0.334930649573587 no 1124 0.354086770624998 362 5984176
SGTC_420 mitomycin C 81.9 mM 0.374146917175501 0.334997885957511 no 1125 0.354147507228795 374 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.3740939656251 0.335019690871972 no 1126 0.354167204020531 413 5393153
SGTC_2297 7971671 152.32 µM 0.373100624295305 0.335428841807282 no 1127 0.354536777027108 387 909016
SGTC_1296 1068-0102 11.9 µM 0.371117039906703 0.336246451394493 no 1128 0.355275179932903 392 767053
SGTC_1082 camptothecin 424.86 nM 0.370171702530478 0.336636381065924 no 1129 0.355627279742493 426 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1196 1588-0294 184 µM 0.369828717209054 0.336777897993227 no 1130 0.355755058337087 396 6144269
SGTC_6 0844-0013 19.835 µM 0.369455662150636 0.336931848039869 no 1131 0.355894057763423 396 1584900
SGTC_1920 st075728 45.7 µM 0.367670435044075 0.33766894230808 no 1132 0.356559494058488 412 3400306
SGTC_701 4424-0219 185 µM 0.3670143413305 0.337939990583569 no 1133 0.356804160267887 383 2911779
SGTC_2435 5706476 10.6 µM 0.365349380184923 0.338628203546792 no 1134 0.357425311048485 368 5725375
SGTC_2484 5809818 12.04 µM 0.363991194600566 0.339190010067693 no 1135 0.357932292363927 366 2870548
SGTC_2002 4023503 131 µM 0.362690617934869 0.339728322284689 no 1136 0.358418004498456 418 4736863 YCR052W RSC6
SGTC_2966 9084041 48.03 µM 0.361604924185416 0.340177944407885 no 1137 0.358823642192561 361 17741380
SGTC_103 0844-0104 51.839 µM 0.361103381497016 0.340385726835746 no 1138 0.359011082750535 371 5375804
SGTC_1885 st057546 99.9 µM 0.360426795034288 0.340666104338679 no 1139 0.359263995856261 375 702008
SGTC_205 1486-1330 71.903 µM 0.359769040662457 0.34093876224355 no 1140 0.359509928517198 391 4118834
SGTC_156 3474-0145 5.642 µM 0.359622562643153 0.340999492869422 no 1141 0.359564704197726 393 2265471
SGTC_2673 kobusone 100 µM 0.358355514840949 0.341524989954749 no 1142 0.360038638994089 411 6710676 An epoxy ketone and protein crosslinker.
SGTC_3342 9147791 14.508 µM 0.358041542649899 0.341655254753047 no 1143 0.36015611249555 395 1838168
SGTC_2653 dihydrofissinolide 100 µM 0.357691727009528 0.341800412952468 no 1144 0.360287012469263 380 6857746
SGTC_85 0868-0259 160.055 µM 0.357463106663712 0.341895293043925 no 1145 0.360372570375241 407 83173
SGTC_2719 novobiocin 32.65 µM 0.356429225632558 0.342324490267537 no 1146 0.360759572868951 400 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2367 9070478 135.38 µM 0.353888078599478 0.343380266826717 no 1147 0.361711380783016 390 572802
SGTC_696 1560-0013 611 µM 0.352852223329817 0.343810987597596 no 1148 0.362099615038169 359 1650269
SGTC_3330 9141424 71.43 µM 0.352576120300183 0.343925828731417 no 1149 0.36220312127937 371 27261020
SGTC_3239 9133757 49.47 µM 0.351964653910705 0.344180210737695 no 1150 0.362432385291273 428 17036923
SGTC_2360 9040895 200 µM 0.347799531706291 0.345914854335579 no 1151 0.363995370689094 359 4914414
SGTC_1996 st072960 66.8 µM 0.347398314460411 0.346082120413248 no 1152 0.364146049726752 390 1719405
SGTC_2780 5215298 71.43 µM 0.347000754429518 0.34624789143645 no 1153 0.364295375997189 406 2834131
SGTC_417 st075190 100 µM 0.34607562239807 0.346633758709568 no 1154 0.364642941637946 427 222757
SGTC_2202 7226349 200 µM 0.345821391067905 0.346739825039169 no 1155 0.364738474078454 368 844334
SGTC_2388 9080168 200 µM 0.345613146317803 0.346826714534188 no 1156 0.364816732411895 408 15943073
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.344274637371782 0.347385395499712 no 1157 0.365319878118505 378 4174840
SGTC_1025 k007-0731 70 µM 0.344024047873057 0.347490026086845 no 1158 0.365414100544066 376 6256118
SGTC_1831 st055328 12 µM 0.343963138158478 0.347515459950756 no 1159 0.365437004012281 393 1103068
SGTC_2602 kawain 100 µM 0.34364981439781 0.347646304341882 no 1160 0.365554828609189 378 5369129
SGTC_162 k030-0015 37.8 µM 0.343343213076674 0.347774359005369 no 1161 0.36567013753191 412 1809920 YMR134W ERG29
SGTC_2342 7990637 118.86 µM 0.342956077779686 0.347936074180713 no 1162 0.365815751615387 406 2033102 YER133W GLC7
SGTC_341 1486-1430 230 µM 0.342733336387941 0.348029130840018 no 1163 0.365899540607399 404 2054753 YPL210C SRP72
SGTC_74 000s-0487 160.283 µM 0.341806879804217 0.348416283025514 no 1164 0.366248115883051 329 677548
SGTC_2897 9048598 12.99 µM 0.339713101033809 0.349291822899598 no 1165 0.36703629735396 386 6467404
SGTC_1605 st000082 49.1 µM 0.339054994073098 0.34956718459205 no 1166 0.367284150931176 414 1114022
SGTC_2659 sanguinarine 24.21 µM 0.338235262004008 0.349910283338661 no 1167 0.367592952445639 405 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2857 9024691 58.44 µM 0.336590740709919 0.350598966916587 no 1168 0.368212718586307 416 16478292
SGTC_2771 fluoxetine 41.05 µM 0.336439919253515 0.350662151725338 no 1169 0.368269575448027 422 3386 A selective serotonin reuptake inhibitor.
SGTC_2883 9059145 45.46 µM 0.335424778655674 0.351087539897445 no 1170 0.368652339428054 429 16476510
SGTC_1417 3966-0327 90.4 µM 0.334795046277191 0.351351519074938 no 1171 0.368889848794054 407 651118
SGTC_3084 9116877 49.47 µM 0.333980765307016 0.351692965982086 no 1172 0.369197036593499 419 27241325
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.333907858476206 0.351723543349183 no 1173 0.369224544800612 403 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3258 9138477 49.47 µM 0.333817828913991 0.351761303370312 no 1174 0.369258514446326 405 4970355
SGTC_2803 7707263 71.43 µM 0.333717337177197 0.351803453143166 no 1175 0.369296432849641 403 2199229
SGTC_3288 9119690 36.221 µM 0.333576265238945 0.351862626754668 no 1176 0.369349665467852 417 17595618 YKL019W RAM2
SGTC_1662 st014054 52 µM 0.331211581986857 0.352855042877204 no 1177 0.370242336171372 417 2838777
SGTC_2430 5571206 200 µM 0.330948655969936 0.352965450340101 no 1178 0.370341634340169 403 1731771
SGTC_968 1309-0633 340 µM 0.330820592300265 0.353019231111261 no 1179 0.370390002740196 407 3761976
SGTC_1817 st052116 64.4 µM 0.330266006077887 0.353252165350384 no 1180 0.370599488195142 380 4361398
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.330246696570462 0.353260276614031 no 1181 0.370606782722757 401 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1404 3909-7820 48.3 µM 0.330038949633113 0.353347548212932 no 1182 0.370685265956179 409 23741373
SGTC_3149 9097855 49.47 µM 0.330032986589921 0.353350053318312 no 1183 0.37068751877119 416 25236625 YMR079W SEC14
SGTC_2224 6650123 117.647 µM 0.329334934861448 0.353643352350177 no 1184 0.37095127067455 425 2908370
SGTC_1148 3909-7663 27.7 µM 0.326342395691608 0.354901704662171 no 1185 0.372082657643512 400 4084526
SGTC_570 0987-0065 62.6 µM 0.326157516768731 0.354979497714639 no 1186 0.37215259102448 425 3104428
SGTC_755 1995-0008 37.3 µM 0.32562418572133 0.355203945753449 no 1187 0.37235435556291 384 689533
SGTC_1317 1273-0028 910 nM 0.323073443039038 0.356278098662211 no 1188 0.373319811044116 413 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2576 guaiol 23.12 µM 0.323002148663853 0.356308138142237 no 1189 0.373346807408182 388 227829
SGTC_1245 0418-0076 17.2 µM 0.32261755827892 0.356470198490769 no 1190 0.373492447316413 413 6790114
SGTC_1760 st045453 10.4495 µM 0.321206781720769 0.357064899313488 no 1191 0.374026846584214 448 3323419 YIL048W NEO1
SGTC_2666 tannic acid 100 µM 0.320473657349633 0.357374078925707 no 1192 0.374304648294015 389 16134267 A thiamine antagonist.
SGTC_2853 9015042 58.44 µM 0.320011211613797 0.357569153761111 no 1193 0.374479915740427 379 6457456
SGTC_2611 pyromycin 23.93 µM 0.319446200526448 0.357807544548394 no 1194 0.374694090772305 377 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3302 9125395 16.351 µM 0.318475748472022 0.358217129345665 no 1195 0.375062043833284 406 17599668
SGTC_780 0109-0199 192 µM 0.317867969825023 0.358473728922466 no 1196 0.375292544910365 430 610414
SGTC_3005 9076496 71.4286 µM 0.317763252886928 0.358517946084487 no 1197 0.375332263485555 413 21368410
SGTC_312 4092-0653 6.84 µM 0.315180870090236 0.359608966764382 no 1198 0.376312164685512 398 1148278
SGTC_3183 9108214 49.47 µM 0.314079239955494 0.360074739139112 no 1199 0.376730428215314 409 4974831
SGTC_616 4092-0450 108 µM 0.314067369240726 0.360079759244218 no 1200 0.376734936040738 412 787165
SGTC_3312 9133330 71.43 µM 0.314050709813042 0.360086804528574 no 1201 0.376741262376563 422 17617324
SGTC_2130 NSC 7 2.4545 µM 0.313612599662963 0.360272098688658 no 1202 0.376907644429694 398 21448
SGTC_1529 apigenin 74 µM 0.313570709851737 0.360289817271457 no 1203 0.376923554213159 428 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1723 st034307 2.5525 µM 0.313111572261831 0.360484043284943 no 1204 0.377097948726159 389 867466
SGTC_1310 1188-0297 994 nM 0.312987121559287 0.360536695067083 no 1205 0.377145223233502 399 1588352
SGTC_68 0986-0284 82.829 µM 0.31236862332416 0.36079840442911 no 1206 0.377380196574421 355 423278 YIL048W NEO1
SGTC_409 arachidonic acid 100 µM 0.311993997272614 0.360956954210238 no 1207 0.377522542644919 394 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1102 cgs 12066b 26.1 µM 0.308725282895407 0.362341355385113 no 1208 0.378765254861153 392 6438352 A 5-HT1B full agonist.
SGTC_1474 0330-0125 5.35 µM 0.308233616548554 0.362549747593465 no 1209 0.378952287286962 387 X1474
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.307795673340977 0.362735403610072 no 1210 0.379118907023231 411 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1057 3448-5381 134 µM 0.306628623762167 0.36323030510642 no 1211 0.379563031945207 401 5497911
SGTC_759 3486-0358 89.3 µM 0.306503349937607 0.363283442577697 no 1212 0.379610714807486 435 875103
SGTC_2708 st078559 56 µM 0.306467245131085 0.363298757663042 no 1213 0.379624457687173 411 17250902
SGTC_206 4546-0025 72.014 µM 0.302653360496529 0.364917773339611 no 1214 0.38107702229146 430 6620745 YIL048W NEO1
SGTC_3118 9124250 49.47 µM 0.302050354658361 0.365173974254363 no 1215 0.381306838525858 432 1504786
SGTC_1978 st071761 42 µM 0.301595105015478 0.365367437428961 no 1216 0.381480369986621 391 5147680
SGTC_1039 k821-0043 94 µM 0.30153830673402 0.365391576867354 no 1217 0.381502021953448 415 15992768
SGTC_313 3474-0040 5.03 µM 0.301076168357104 0.365588006863437 no 1218 0.381678206639316 413 1043375 YIL048W NEO1
SGTC_1672 st016598 6.51 µM 0.300199913359414 0.365960552165392 no 1219 0.382012335578426 428 4665860 YNL267W PIK1
SGTC_1443 4112-3303 14 µM 0.300028458665698 0.366033462001362 no 1220 0.38207772406904 410 704433
SGTC_353 1988-1175 58.3 µM 0.299882329863533 0.366095606008711 no 1221 0.382133456559364 419 2788357
SGTC_1880 MG-132 525 µM 0.298929629436422 0.366500845727875 no 1222 0.382496869574081 438 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_610 4215-0184 155 µM 0.297654663880538 0.367043396710041 no 1223 0.38298337436288 425 5605015
SGTC_647 0140-0236 81 µM 0.295730725130089 0.367862615429051 no 1224 0.383717865438226 416 990837
SGTC_3157 9099274 49.47 µM 0.294975087133694 0.368184532994765 no 1225 0.384006455496102 440 17217662
SGTC_1453 4237-0541 195 µM 0.294882941101963 0.368223795465792 no 1226 0.384041651921449 399 739892
SGTC_1200 1643-0193 18.4 µM 0.294759241175859 0.368276504888745 no 1227 0.384088902287941 432 5403974
SGTC_2647 atorvastatin 60.16 µM 0.293819580354231 0.368676981970162 no 1228 0.384447886096743 421 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3339 9145883 14.936 µM 0.293665677406102 0.368742587972755 no 1229 0.38450669194421 433 2030670
SGTC_1295 1013-0063 9.78 µM 0.292690360229185 0.369158436652241 no 1230 0.384879419404445 428 6826038
SGTC_1338 1486-1223 76 µM 0.292579386905188 0.369205762369722 no 1231 0.384921835747178 439 3444526
SGTC_2523 spermine 47.74 µM 0.292349908971274 0.369303631886823 no 1232 0.385009551416763 404 1103 A DNA binding polyamine.
SGTC_1552 6-methylflavone 10.6 µM 0.290638383622131 0.37003384321644 no 1233 0.38566395038287 433 689013
SGTC_3180 9109287 49.47 µM 0.288829910846208 0.370805925888337 no 1234 0.386355770794936 396 18891271
SGTC_1712 st032288 53.4 µM 0.288254343964999 0.371051759252484 no 1235 0.386576026377283 423 2883011
SGTC_2699 st077704 54.6 µM 0.286886456502544 0.371636215797808 no 1236 0.387099630474056 394 645852
SGTC_618 k072-0232 33.2 µM 0.286839235676979 0.371656397108074 no 1237 0.387117709479328 433 5872756 YGL099W LSG1
SGTC_839 0122-0028 230 µM 0.283880439513404 0.372921633430557 no 1238 0.388251003548368 421 759448
SGTC_2835 9006588 71.43 µM 0.283548483803078 0.373063669720271 no 1239 0.388378210598136 357 2345538
SGTC_868 0527-0199 213 µM 0.283357835457196 0.373145251608076 no 1240 0.388451273389611 410 2849450
SGTC_671 0560-0003 407 µM 0.281985276744464 0.373732762072685 no 1241 0.388977399922521 440 3238678
SGTC_2537 larixol 68.93 µM 0.281025269215232 0.37414385853579 no 1242 0.38934550923891 428 6708759
SGTC_3121 9125696 49.47 µM 0.280533330849009 0.374354572935385 no 1243 0.389534178659573 442 1235365
SGTC_2031 5180455 200 µM 0.279167989956907 0.374939592649875 no 1244 0.390057953874631 430 29949
SGTC_2755 lomerizine 42.69 µM 0.277394859919115 0.3756997709196 no 1245 0.390738464010665 404 3949 A calcium channel blocker.
SGTC_1753 st043925 64 µM 0.27590505093117 0.376338856835023 no 1246 0.391310497179508 423 670181
SGTC_920 mycophenolic acid 780.421 nM 0.275366691439134 0.376569881349782 no 1247 0.391517265807036 403 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_553 k007-0256 45.7 µM 0.274224917352505 0.377059993507732 no 1248 0.391955890264764 410 6287000
SGTC_275 trichlorophene 5.69 µM 0.274165171049916 0.377085645364868 no 1249 0.391978846218228 424 62616
SGTC_1597 7-benzyloxygramine 47.5 µM 0.273344054118087 0.37743824383829 no 1250 0.392294376977912 429 260807
SGTC_2064 5220758 200 µM 0.272608285770381 0.377754279316009 no 1251 0.392577170994334 396 788518
SGTC_2120 5538279 151.968 µM 0.2717947362245 0.37810381952663 no 1252 0.392889926401832 412 2058197
SGTC_3031 9088762 49.47 µM 0.271169203763853 0.378372646394601 no 1253 0.393130448855048 412 205253
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.270494460331527 0.378662688025212 no 1254 0.3933899390784 423 688788
SGTC_2046 4110841 106 µM 0.27047594234585 0.378670649032734 no 1255 0.393397061322107 451 44119630 YMR134W ERG29
SGTC_2658 polymyxin b sulfate 77.05 µM 0.269316249914805 0.379169311109888 no 1256 0.393843164188151 410 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1836 st055642 81 µM 0.26882964378367 0.379378609319724 no 1257 0.394030390173025 448 8571
SGTC_31 0508-1974 57.237 µM 0.26813606437311 0.379676991627189 no 1258 0.394297293271873 416 6810525
SGTC_2106 5357045 167.29 µM 0.267328490691971 0.380024505289456 no 1259 0.394608126166755 423 668842
SGTC_2220 6782180 200 µM 0.264083590966427 0.381421818924891 no 1260 0.395857753854867 436 833803
SGTC_2133 5320837 200 µM 0.263169108760269 0.381815892036921 no 1261 0.396210119717533 425 2841355
SGTC_1373 2887-0003 58.5 µM 0.263051644810431 0.381866519059271 no 1262 0.396255386768119 405 776948
SGTC_1779 st039427 55 µM 0.26256997969012 0.382074138092359 no 1263 0.396441020546192 434 1124498
SGTC_816 0325-0417 81.3 µM 0.262555304651054 0.382080464217876 no 1264 0.396446676676256 434 68101
SGTC_723 4182-0001 115 µM 0.261011622226958 0.382746091381574 no 1265 0.397041772302494 437 744821 YLR208W SEC13
SGTC_1147 3809-1045 12.3 µM 0.259190722808085 0.383531698247643 no 1266 0.397744044357863 425 325925
SGTC_2077 5212015 200 µM 0.259120454767828 0.383562024235065 no 1267 0.397771151513348 440 780900
SGTC_909 3448-9333 149 µM 0.256005750641031 0.384906969251584 no 1268 0.398973198442379 424 3344074
SGTC_1821 st053465 65.6 µM 0.255615951346608 0.385075384473261 no 1269 0.399123700061454 403 675086
SGTC_1288 0973-0013 65.5 µM 0.254786580077018 0.385433791620055 no 1270 0.399443970418291 422 4315430
SGTC_165 k038-0023 64.381 µM 0.254524049798525 0.385547262698296 no 1271 0.399545363333747 418 46368543
SGTC_1238 0333-0287 48.8 µM 0.254360482698719 0.385617964774479 no 1272 0.399608538692681 411 7226
SGTC_3032 9089427 49.47 µM 0.254025721694286 0.385762677469421 no 1273 0.399737843343383 451 17173707
SGTC_2189 6047310 154.431 µM 0.253657704855643 0.38592178456406 no 1274 0.399880006067803 425 711535
SGTC_3134 9127454 49.47 µM 0.252324427436515 0.38649836952515 no 1275 0.400395154240158 456 24262820
SGTC_678 1218-2179 85.9 µM 0.252142517519888 0.3865770571786 no 1276 0.400465453565655 467 6820081 YOR116C RPO31
SGTC_2872 9044037 25.97 µM 0.251759227271152 0.386742869945834 no 1277 0.4006135871364 429 6465195
SGTC_3059 1327-0034 3 µM 0.251445036088252 0.386878805626613 no 1278 0.400735026042999 404 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3275 9138069 49.47 µM 0.248496425947306 0.388155204048923 no 1279 0.401875167528341 450 17617007
SGTC_472 calcifediol 10 µM 0.246933719574483 0.388832161639543 no 1280 0.402479759887335 424 5283731 A vitamin D metabolite.
SGTC_1033 k072-0102 21.3 µM 0.246455666064248 0.389039319885097 no 1281 0.402664759733667 449 5965931
SGTC_956 1185-0240 191 µM 0.24587314642477 0.389291789801539 no 1282 0.402890215931803 424 1416193
SGTC_832 4083-0019 164 µM 0.244467738772423 0.389901099956975 no 1283 0.403434292398188 410 1990758
SGTC_3336 9143619 71.43 µM 0.24338679951828 0.390369922058766 no 1284 0.403852884435072 440 45595730
SGTC_127 0180-0333 59.125 µM 0.243156806475846 0.390469694627033 no 1285 0.403941963107383 419 771601
SGTC_940 3232-1287 54.8 µM 0.242601486319223 0.390710626063677 no 1286 0.404157064846422 450 1585493 YIL048W NEO1
SGTC_895 0964-0006 13.7 µM 0.242289043814917 0.390846200953034 no 1287 0.404278101337069 450 6738897
SGTC_335 4077-0256 27.6 µM 0.240948382335376 0.391428090509214 no 1288 0.404797561439482 453 3121989
SGTC_505 gw-5074 63.9 µM 0.239586451617324 0.392019460462392 no 1289 0.40532543447711 451 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1911 st060208 74.3 µM 0.238450199341907 0.392513028580534 no 1290 0.405765968281847 424 688783
SGTC_997 3996-0078 137 µM 0.237952517922862 0.392729267193575 no 1291 0.405958960846868 428 735687
SGTC_2678 equilin 100 µM 0.237670734907242 0.392851714356307 no 1292 0.40606824174402 425 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_594 1487-1584 10.8 µM 0.237404845274101 0.39296726486666 no 1293 0.406171365591932 428 5013332
SGTC_2645 abamectin 100 µM 0.235966168970476 0.393592649203052 no 1294 0.406729461098783 439 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1857 st056007 79.3 µM 0.235273975663471 0.393893639602841 no 1295 0.406998046330649 421 619834
SGTC_1572 epiandrosterone 68.9 µM 0.231037828850447 0.395737042550814 no 1296 0.408642706876645 434 441302 A steroid.
SGTC_944 3370-0224 231 µM 0.230844028717595 0.395821432835046 no 1297 0.40871798744115 413 4580514
SGTC_2990 9074105 71.4286 µM 0.230632739562318 0.395913444280132 no 1298 0.408800065354879 469 6502001
SGTC_1045 1348-1485 165 µM 0.23034094472412 0.396040523586835 no 1299 0.408913423282934 406 6810614
SGTC_2372 9071633 200 µM 0.229960571554933 0.396206196149964 no 1300 0.409061204005434 443 21321366
SGTC_1219 1469-0211 33.1 µM 0.229190691551938 0.396541576810658 no 1301 0.409360353556919 475 6822282
SGTC_2826 7992541 19.48 µM 0.22918215776796 0.396545294788449 no 1302 0.409363669795322 485 2985066
SGTC_2471 5466956 24.79 µM 0.229101847576598 0.396580284593764 no 1303 0.409394878747013 441 724419
SGTC_2652 actinonin 100 µM 0.228834388966782 0.396696817834388 no 1304 0.409498818672125 452 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1955 wogonin 32.4 µM 0.227406477892782 0.39731912271504 no 1305 0.410053841801838 394 5281703 A flavanone.
SGTC_2778 tioconazole 65.09 nM 0.226217464303717 0.397837512108862 no 1306 0.41051614405344 450 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_403 arphamenine a 50 µM 0.226197502345523 0.397846216720474 no 1307 0.410523906557156 469 5487158 An arginine aminopeptidase inhibitor.
SGTC_2033 5192550 145 µM 0.226187191952093 0.397850712690612 no 1308 0.410527915920393 448 182073
SGTC_3165 9101544 49.47 µM 0.224803094249562 0.398454387935022 no 1309 0.411066229412344 454 5002184
SGTC_138 0850-0259 40.9225 µM 0.224658105246661 0.398517639086834 no 1310 0.411122629315545 447 6813004
SGTC_2946 9065502 71.43 µM 0.22272015503494 0.3993633211807 no 1311 0.411876656941281 429 16489101
SGTC_2470 5664817 21.68 µM 0.222554924743042 0.399435446236177 no 1312 0.411940960690508 454 2859561
SGTC_1161 k007-0610 110 µM 0.222471225316044 0.399471983375824 no 1313 0.411973535444268 448 5843850
SGTC_3082 9117008 49.47 µM 0.218703489889202 0.401117612445668 no 1314 0.413440515129684 424 41448529
SGTC_2096 5468907 200 µM 0.218592173908041 0.401166258633878 no 1315 0.413483874848118 466 759785
SGTC_119 0121-0043 24.815 µM 0.21842416892947 0.401239681377533 no 1316 0.413549318020478 458 1092378
SGTC_3173 9105693 49.47 µM 0.218112623179402 0.401375844569764 no 1317 0.413670681149081 445 17096658
SGTC_3064 1327-0027 10 µM 0.218012361615736 0.401419667117424 no 1318 0.413709739950874 467 16000455 YPR107C YTH1
SGTC_2433 5607874 27.82 µM 0.216821989818533 0.401940052082087 no 1319 0.414173537095502 461 2252428
SGTC_2067 5224629 34.075 µM 0.215691794835848 0.402434290998181 no 1320 0.41461399872822 426 2835000
SGTC_3309 9129340 25.759 µM 0.215242708620566 0.40263072160069 no 1321 0.414789047262818 412 17158987
SGTC_743 1275-0778 158 µM 0.214531225292639 0.402941975178984 no 1322 0.415066409738539 456 2849257 YMR203W TOM40
SGTC_3125 9127534 49.47 µM 0.212657821344114 0.403761829500251 no 1323 0.415796933943544 456 1639235
SGTC_646 4092-0839 27.3 µM 0.211911643658823 0.404088495867832 no 1324 0.416087983280817 465 877796
SGTC_3353 9151644 39.2805 µM 0.211841142456168 0.404119363790701 no 1325 0.416115484915124 476 4909158
SGTC_3177 9107506 49.47 µM 0.211420235225471 0.404303664295256 no 1326 0.416279684084809 468 8897194
SGTC_1130 3454-2858 15.9 µM 0.210898247788097 0.404532253773754 no 1327 0.416483335720222 478 715628 YIL048W NEO1
SGTC_2842 9000675 19.48 µM 0.210728945453176 0.404606401895458 no 1328 0.41654939327209 477 2989072
SGTC_2757 clomiphene 4.22 µM 0.210337316024964 0.404777934133657 no 1329 0.416702206343294 472 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2107 5363541 170.161 µM 0.209623278732664 0.405090726898994 no 1330 0.416980854744103 477 244052
SGTC_1992 st073643 23.3 µM 0.209283351810186 0.405239657361497 no 1331 0.417113523674156 454 3161292
SGTC_1406 3909-7906 11.9 µM 0.20827013880792 0.405683652578433 no 1332 0.417509023090756 465 X1406
SGTC_441 propafenone 146 µM 0.207453205853517 0.406041725262473 no 1333 0.417827966992627 470 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_789 1309-1135 70.6 µM 0.207114190053508 0.406190343537695 no 1334 0.417960340153496 426 3092424
SGTC_2555 cholic acid 100 µM 0.206230678757382 0.406577722065694 no 1335 0.418305362354405 439 6708657 Influences liver metabolism.
SGTC_866 0495-0101 262 µM 0.204195505968177 0.407470397817389 no 1336 0.419100361546019 456 635694
SGTC_2605 digitonin 300 nM 0.203667554023 0.407702048957694 no 1337 0.419306649429915 460 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2681 menadione 3.18 µM 0.202999078750819 0.407995404255702 no 1338 0.419567876136007 460 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_158 k038-0087 26.446 µM 0.202974997848812 0.408005972940269 no 1339 0.419577287130912 437 X158
SGTC_12 0849-0099 9.267 µM 0.201606969506623 0.408606486214591 no 1340 0.420111998116413 466 6071388
SGTC_1312 1218-2183 165 µM 0.200261800854653 0.409197174255884 no 1341 0.420637917930726 462 6744073
SGTC_1302 1159-0335 255 µM 0.200094137528156 0.409270812756843 no 1342 0.420703479114872 447 649284
SGTC_2168 5727979 200 µM 0.199990714961269 0.409316238018699 no 1343 0.420743921410827 456 695210
SGTC_1891 st059073 26.2 µM 0.199870226491625 0.409369160502288 no 1344 0.420791038201643 479 688754
SGTC_2608 thymoquinone 42.66 µM 0.199861773113098 0.409372873565125 no 1345 0.420794343922118 458 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3217 9129673 49.47 µM 0.199521955846338 0.409522141664511 no 1346 0.420927235164099 412 17248312
SGTC_2847 9005661 71.43 µM 0.198899237700304 0.409795710803976 no 1347 0.421170782914302 462 2991449
SGTC_1828 st055811 49 µM 0.197368743548844 0.410468265503895 no 1348 0.421769493770643 479 5877589
SGTC_2879 9041815 71.43 µM 0.197260765185244 0.410515725086559 no 1349 0.421811740451039 452 4942971
SGTC_716 1683-5115 658 µM 0.196659953342179 0.410779823006674 no 1350 0.422046825315235 478 723597
SGTC_3142 9086498 49.47 µM 0.194794394080518 0.411600121269179 no 1351 0.42277695555101 467 25236367
SGTC_1748 st037455 53.6035 µM 0.19455995282604 0.41170323399183 no 1352 0.422868728438083 457 580690
SGTC_21 0849-0113 22.993 µM 0.192300115876621 0.412697474570206 no 1353 0.423753563817958 442 1560156
SGTC_2450 5739737 12.93 µM 0.192200001249639 0.412741534130979 no 1354 0.423792772461587 469 2262825
SGTC_2010 4012422 159 µM 0.1906180388684 0.413437887349794 no 1355 0.424412428178599 452 952393
SGTC_1166 k206-0078 225 µM 0.190156516750456 0.413641093037473 no 1356 0.424593241979862 424 5404595
SGTC_459 nigericin 15.3 µM 0.188228725926076 0.41449013837932 no 1357 0.425348677453472 469 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1125 tnp00248 1.32998 µM 0.187076711602936 0.414997704185574 no 1358 0.425800243622764 461 24207736
SGTC_2163 5671233 125 µM 0.186919178137699 0.415067122878846 no 1359 0.425862001112752 437 701023
SGTC_2316 5844804 197.44 µM 0.186837139279755 0.415103275170363 no 1360 0.425894163341887 457 776813
SGTC_287 k060-0039 29.6 µM 0.186417296176612 0.415288299844143 no 1361 0.426058764887456 440 5861974
SGTC_91 0417-1751 58.384 µM 0.186397323962648 0.415297102058631 no 1362 0.426066595413022 485 6795624
SGTC_1504 k297-0033 30 µM 0.185834829498599 0.415545023761333 no 1363 0.426287145131347 432 4388117
SGTC_3022 9087993 49.47 µM 0.184227316323298 0.416253726702852 no 1364 0.426917565447902 475 17173644
SGTC_369 0957-0393 4.5 µM 0.183717768768598 0.416478427452125 no 1365 0.427117434356065 445 6997992
SGTC_2563 tomatine 8.54 µM 0.183663807527687 0.416502224929438 no 1366 0.427138601630744 484 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1539 benzyladenosine 56 µM 0.183442076050637 0.416600014064873 no 1367 0.427225582022446 425 92208 A nucleotide analog.
SGTC_1423 4048-0112 5.59 µM 0.183154537861351 0.416726833294611 no 1368 0.427338382211212 477 X1423
SGTC_2524 avocatin b 10.57 µM 0.182820261542518 0.416874277353513 no 1369 0.427469525065647 476 6710748
SGTC_3252 9135871 49.47 µM 0.182264395514106 0.417119487050035 no 1370 0.427687619447335 465 17682838
SGTC_3194 9111903 49.47 µM 0.180539056294244 0.417880792480418 no 1371 0.428364697807971 478 17087251
SGTC_244 nsc-207895 1.295 µM 0.178603594680481 0.418735180605105 no 1372 0.429124485865239 457 42640
SGTC_1815 st051655 58.2 µM 0.177633156501858 0.41916371440021 no 1373 0.429505541752837 465 5984156
SGTC_2849 9019321 12.99 µM 0.17708404634484 0.419406237346286 no 1374 0.429721186526939 463 16489627
SGTC_1091 telmisartan 47.6 µM 0.176131556439873 0.419826991733752 no 1375 0.43009529499649 464 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_475 α-linolenic acid 10 µM 0.173231727386111 0.421108529164201 no 1376 0.431234642892136 450 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_787 4152-0075 138 µM 0.172935084125451 0.421239673735514 no 1377 0.43135122698093 450 9566539
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.17170084168127 0.421785420093994 no 1378 0.431836362038004 492 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_3278 9139605 49.47 µM 0.171584379037197 0.421836924285197 no 1379 0.431882144516085 457 7958859
SGTC_1067 clotrimazole 1.36 µM 0.168999801792358 0.422980264720661 no 1380 0.432898398651784 464 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2275 7947463 200 µM 0.167209644474811 0.423772558352178 no 1381 0.433602548030934 488 1225414
SGTC_2909 7941780 10.49 µM 0.167080571921623 0.423829695653234 no 1382 0.433653326244541 471 1243215
SGTC_333 3486-0131 40.1 µM 0.166476490127198 0.42409712933637 no 1383 0.433890991578154 489 6744690
SGTC_1063 disulfiram 1.84 µM 0.164462546340482 0.424988976361227 no 1384 0.434683514463955 455 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1195 1502-0147 41.1 µM 0.164196623092279 0.425106765578991 no 1385 0.434788179705808 487 817940
SGTC_2137 5261020 140 µM 0.161776670372693 0.426178976123515 no 1386 0.435740862679925 467 763655
SGTC_1168 k815-0004 80.5 µM 0.161596406188921 0.426258867876366 no 1387 0.435811843781007 472 642433
SGTC_166 k072-0058 166.424 µM 0.159876871384289 0.427021104642255 no 1388 0.436489034052284 501 5846229
SGTC_2460 5552655 174.22 µM 0.159108246463098 0.42736190963385 no 1389 0.436791795624803 440 5401989
SGTC_2630 antimycin a 100 µM 0.159082944697077 0.427373129251405 no 1390 0.436801762628022 462 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1397 3532-0190 20.1 µM 0.157788493334881 0.427947208833261 no 1391 0.43731173302864 451 5322280
SGTC_1681 tripelennamine 100 µM 0.157776311590509 0.427952612073031 no 1392 0.437316532723243 438 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_331 k048-0133 24.5 µM 0.155997528410572 0.428741739803086 no 1393 0.438017484707145 452 6813582
SGTC_2918 7977171 22.06 µM 0.155498743790851 0.428963068638037 no 1394 0.438214072102891 473 2236483
SGTC_455 paf C-16 10 µM 0.154368288517685 0.429464775244107 no 1395 0.438659678009881 472 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1188 1403-0014 4.57 µM 0.154317122892728 0.429487485727742 no 1396 0.438679848457626 481 9614867
SGTC_3264 9137442 49.47 µM 0.15423205086955 0.429525246494293 no 1397 0.438713385795167 436 17015726
SGTC_1925 st057770 10.1 µM 0.154044031545002 0.429608704581986 no 1398 0.438787508874454 426 5989122
SGTC_1217 1183-1422 255 µM 0.153558187269304 0.429824375878482 no 1399 0.438979053769255 466 2849664
SGTC_1385 3091-4834 14.1 µM 0.152727484914436 0.430193181724296 no 1400 0.439306592604267 461 4072814
SGTC_1282 0886-0010 32.4 µM 0.151368709071347 0.430796566826933 no 1401 0.439842435781115 499 2836211 YNL267W PIK1
SGTC_2695 st077686 51.995 µM 0.151321993838005 0.43081731431874 no 1402 0.439860860239947 464 2876092
SGTC_2287 7945887 168.79 µM 0.151140545581241 0.430897902181328 no 1403 0.439932424554051 481 1245853
SGTC_212 3807-4682 38.772 µM 0.151023209348416 0.430950017061829 no 1404 0.439978703734682 456 3125501 YBL034C STU1
SGTC_157 1348-1695 65.819 µM 0.149854436289408 0.431469193035066 no 1405 0.440439730131609 464 5380510
SGTC_734 2023-0417 80 µM 0.149516908530209 0.431619146957196 no 1406 0.440572884126973 494 3935732
SGTC_2594 a-mangostin 100 µM 0.149040589659218 0.431830778558913 no 1407 0.44076080235522 483 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2889 9059656 51.95 µM 0.148425970870196 0.432103886626014 no 1408 0.441003302638234 460 3949838
SGTC_1755 st041960 45.185 µM 0.145825506087173 0.433259770066034 no 1409 0.442029570094519 487 2257073
SGTC_794 k038-0031 316 µM 0.145676660841359 0.433325947827446 no 1410 0.442088323371169 491 6624242
SGTC_1683 st010134 710 nM 0.145405906436258 0.433446332147473 no 1411 0.442195200782261 471 3818134
SGTC_1250 0485-0349 40.2 µM 0.144744858166848 0.433740277003409 no 1412 0.442456160192188 469 6842794 YDL195W SEC31
SGTC_247 mechlorethamine 29.705 µM 0.144676542530504 0.4337706566502 no 1413 0.442483130311197 489 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3168 9103419 49.47 µM 0.144533178894555 0.433834411066336 no 1414 0.442539729264625 495 16649256
SGTC_2987 9018338 71.43 µM 0.144416248074717 0.433886411971836 no 1415 0.442585893596903 487 5055682
SGTC_3219 9131112 49.47 µM 0.144114053880468 0.434020807601876 no 1416 0.442705203589305 466 17612988 YMR079W SEC14
SGTC_1980 st071811 45.7 µM 0.144087990804689 0.434032399060582 no 1417 0.442715493856398 489 4974850
SGTC_2785 7756463 72.73 µM 0.143765569897235 0.43417579928156 no 1418 0.442842795811218 504 2201551
SGTC_378 3970-0959 8.33 µM 0.142331742495318 0.434813614342705 no 1419 0.443408987433683 492 6615653
SGTC_79 0052-0007 94.094 µM 0.140335948800685 0.435701693189549 no 1420 0.444197281159031 492 2801472
SGTC_3135 9127742 49.47 µM 0.139250200199051 0.436184960978745 no 1421 0.444626220430382 498 3643468
SGTC_2790 5423970 71.43 µM 0.139151365721508 0.436228957045998 no 1422 0.444665269519278 460 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1184 1269-1718 139 µM 0.136390110552205 0.437458443996911 no 1423 0.445756445629597 466 5403821
SGTC_1729 st035615 45.989 µM 0.134892333481399 0.438125603395724 no 1424 0.446348500572541 499 17385451
SGTC_551 k048-0028 34.9 µM 0.134160616613373 0.438451598342668 no 1425 0.4466377838496 489 6836383
SGTC_1772 st048439 82.2 µM 0.133947789390608 0.438546425107523 no 1426 0.446721930143332 502 2927068 YDL195W SEC31
SGTC_1017 4239-0030 168 µM 0.133907942998427 0.438564179358579 no 1427 0.446737684626907 472 1149593
SGTC_2796 7949634 45.45 µM 0.132907848336637 0.439009829278399 no 1428 0.447133129949504 472 2971588
SGTC_178 4092-0806 87.505 µM 0.130898617362435 0.439905391308068 no 1429 0.447927754228606 481 2169044
SGTC_648 0375-0473 33.3 µM 0.130268355670849 0.440186377522012 no 1430 0.448177057607424 486 1713139
SGTC_3071 9117417 49.47 µM 0.129865292819881 0.440366088689315 no 1431 0.448336502008407 493 45595590 YGL055W OLE1
SGTC_2585 alliin 100 µM 0.129808341811989 0.440391482078126 no 1432 0.448359031474458 499 87310 A garlic compound which reacts with lipids.
SGTC_3126 9127922 49.47 µM 0.128634205424356 0.44091506200265 no 1433 0.448823549567259 503 45595682
SGTC_1333 1482-0047 286 µM 0.126888763342551 0.441693593608719 no 1434 0.449514220152316 509 3811116
SGTC_1034 k072-0165 12.7 µM 0.126682390610408 0.441785658419037 no 1435 0.449595891895955 496 5835461
SGTC_1361 1608-0041 5.61 µM 0.125839340454843 0.442161783609124 no 1436 0.449929550053121 498 X1361
SGTC_1428 4049-0204 61.7 µM 0.125795287581899 0.442181439149459 no 1437 0.449946986053198 486 X1428
SGTC_444 curcumin 90.4 µM 0.125488455025597 0.442318345850655 no 1438 0.450068432172587 477 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_35 0133-0054 64.071 µM 0.124596260282639 0.442716476455107 no 1439 0.4504215945942 480 99677
SGTC_3129 9127257 49.47 µM 0.124450523162294 0.442781515306773 no 1440 0.450479286269156 484 837894
SGTC_1716 st033144 30.6155 µM 0.12406121910237 0.442955259581127 no 1441 0.450633401778689 501 674617
SGTC_885 0865-0106 16.8 µM 0.123988696061506 0.442987627431037 no 1442 0.450662112616855 504 2793380
SGTC_1010 4112-3296 15.2 µM 0.123635477098175 0.443145278467771 no 1443 0.450801950657813 497 704384
SGTC_1903 st060211 78.3 µM 0.123602744665244 0.443159888280992 no 1444 0.450814909612665 481 688960
SGTC_1177 0983-0204 23.6 µM 0.123380434335011 0.443259116447247 no 1445 0.450902924913114 481 766818
SGTC_1263 0774-1208 64.8 µM 0.12307490584015 0.443395494827223 no 1446 0.451023891211463 500 906585
SGTC_1247 0448-0043 5.84 µM 0.120884022374847 0.444373632266983 no 1447 0.451891448826998 481 3089013 YGL099W LSG1
SGTC_2343 7990716 14.84 µM 0.119024361627172 0.445204158830437 no 1448 0.45262802759335 498 6456862
SGTC_2843 9000894 45.46 µM 0.117943244897789 0.445687097582361 no 1449 0.453056313940617 479 2242070
SGTC_3100 9120536 49.47 µM 0.117633569590452 0.445825445542998 no 1450 0.453179002457611 493 16421196
SGTC_3245 9134821 49.47 µM 0.117434835640002 0.445914233743242 no 1451 0.453257740098051 478 17014901
SGTC_805 3852-0218 479 µM 0.116379948708369 0.446385569995112 no 1452 0.453675713006562 491 6615355
SGTC_2405 ticlatone 3.52 µM 0.115547236067133 0.446757689624567 no 1453 0.454005691102087 413 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2622 2-methoxyxanthone 59.94 µM 0.114820814147952 0.447082348740635 no 1454 0.454293575431995 497 71034 A hepatoprotective.
SGTC_2008 4012253 172 µM 0.114061245307522 0.447421860107729 no 1455 0.454594621717539 494 603940
SGTC_828 2074-0507 139 µM 0.113736544263751 0.447567006445635 no 1456 0.454723321172163 509 X828
SGTC_1260 0700-1617 7.75 µM 0.113207217761602 0.447803638541454 no 1457 0.454933136755262 504 2853078
SGTC_123 0083-0120 66.675 µM 0.112452582699998 0.448141025518036 no 1458 0.455232282357974 504 16001701
SGTC_736 0958-0254 92.6 µM 0.111312728278425 0.448650709836411 no 1459 0.455684181212626 515 6812352
SGTC_2374 9071832 200 µM 0.111285934693248 0.448662691573649 no 1460 0.45569480430541 504 17381698
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.110569478388781 0.448983098697577 no 1461 0.45597887587964 515 688669
SGTC_379 3970-0972 5.9 µM 0.110509389147868 0.449009972780951 no 1462 0.456002702007534 481 2898042 YBL034C STU1
SGTC_3293 9120939 62.045 µM 0.110484899684877 0.449020925422264 no 1463 0.456012412428161 497 934087
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.11042587377816 0.449047324265478 no 1464 0.456035817148242 509 140250 A respiratory chain inhibitor.
SGTC_2059 5238311 157 µM 0.109866683574732 0.449297428582485 no 1465 0.456257552602638 481 703021
SGTC_1948 st076329 66.6 µM 0.108668334430596 0.449833471883915 no 1466 0.456732779271971 507 24208413
SGTC_1798 st045719 60.953 µM 0.108022647663635 0.450122337299029 no 1467 0.456988863545104 508 3980186
SGTC_2575 plumbagin 510 nM 0.107267868791355 0.45046004150619 no 1468 0.457288237211784 505 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1149 3909-7961 23.3 µM 0.106414738977032 0.450841793201757 no 1469 0.457626649732307 509 735261
SGTC_650 1328-0195 38 µM 0.10495130847744 0.451496743081378 no 1470 0.458207222730415 511 2780821
SGTC_1555 citronellol 128 µM 0.10401673316964 0.451915076076131 no 1471 0.458578034726601 509 8842 A terpine precursor.
SGTC_3261 9137475 49.47 µM 0.102782394327123 0.452467670467987 no 1472 0.459067839272017 515 17027690
SGTC_514 4466-0038 2.65 nM 0.101894644226491 0.452865159436419 no 1473 0.459420150562662 506 5722064
SGTC_225 nsc-122657 1.016 µM 0.101487207408357 0.453047604587592 no 1474 0.45958185606772 503 275685
SGTC_2184 6075246 200 µM 0.100947010346322 0.453289513404703 no 1475 0.459796262409054 506 2267320
SGTC_327 1273-0057 3.96 µM 0.100642817000258 0.45342574364732 no 1476 0.459917003095865 522 3108138
SGTC_1499 4480-0877 67.3 µM 0.0999617923853472 0.453730754217416 no 1477 0.460187329361911 500 2861909
SGTC_782 0083-0095 30.5 µM 0.0998096957811469 0.453798877475192 no 1478 0.460247705185785 472 3591729 An indicator and reagent.
SGTC_2570 licareol 100 µM 0.0989244314609358 0.45419540956054 no 1479 0.460599135273718 487 443158
SGTC_2748 diazoxide 86.69 µM 0.0978795672205642 0.45466348917023 no 1480 0.461013962531575 514 3019 A potassium channel activatior.
SGTC_1968 st069590 43.6 µM 0.0976126627481091 0.454783067496366 no 1481 0.461119934554613 508 6384066
SGTC_2767 sibutramine 71.45 µM 0.0971655835692691 0.454983376723992 no 1482 0.461297449508157 503 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_253 dyclonine 31.25 µM 0.0969628163386399 0.45507422827217 no 1483 0.46137796176322 466 3180 An oral anasthetic.
SGTC_2474 5321570 43.32 µM 0.095960853327396 0.455523200556773 no 1484 0.461775831775092 516 2841384
SGTC_2534 helenine 20.12 µM 0.0959496720938001 0.455528211107202 no 1485 0.461780271953518 507 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1627 st003713 25.6 µM 0.0954685794404807 0.455743805726229 no 1486 0.461971323108031 494 16195070 YER133W GLC7
SGTC_1225 1216-0074 20.6 µM 0.0948170019119909 0.456035821409179 no 1487 0.462230091070781 503 4241466
SGTC_914 3820-6779 408 µM 0.0927952613860749 0.456942049693085 no 1488 0.463033107817323 504 2893481
SGTC_1709 st033179 39.1045 µM 0.0918061374859494 0.457385498094655 no 1489 0.463426033825105 514 573381
SGTC_681 1642-0006 26.6 µM 0.0912501151934804 0.457634799801242 no 1490 0.463646927426268 516 4446530
SGTC_1668 st014914 51.6 µM 0.0911965943999822 0.457658797607166 no 1491 0.463668190476987 515 2839556
SGTC_1906 st060206 94.7 µM 0.0904925771201353 0.457974481219406 no 1492 0.463947896176721 507 5133468
SGTC_107 0358-0022 2.6945 µM 0.0904426013958769 0.457996891505031 no 1493 0.463967752185032 516 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2899 9053889 58.44 µM 0.0901042039056441 0.458148640377536 no 1494 0.46410220428877 518 6470052
SGTC_641 4092-0595 30 µM 0.0899990281357162 0.458195805991415 no 1495 0.464143993565517 491 786260
SGTC_2416 tofa 880 nM 0.0899168044453231 0.458232679255644 no 1496 0.464176663614273 444 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0898961599543652 0.458241937346702 no 1497 0.464184866355391 499 616764
SGTC_1722 st034304 3.6505 µM 0.0888479703904113 0.458712031131257 no 1498 0.464601366774773 500 4036148 YLR033W RSC58
SGTC_1839 st053978 48 µM 0.0881609725614672 0.459020168419194 no 1499 0.464874367938679 501 3788398
SGTC_2136 5328288 199.296 µM 0.0875043641531365 0.459314698237755 no 1500 0.465135308323609 506 262395
SGTC_207 4185-0010 4.486 µM 0.0874795683178234 0.459325821154814 no 1501 0.465145162641787 494 3761753
SGTC_757 1066-0008 322 µM 0.0872118139999883 0.459445932426629 no 1502 0.465251574462165 479 6842497
SGTC_2399 5884133 200 µM 0.0870632749400355 0.459512566806875 no 1503 0.465310608426425 487 722445
SGTC_1674 st016616 23.6 µM 0.0859192314086874 0.460025820845699 no 1504 0.46576531179417 515 625830
SGTC_2131 toluylene red 5.2905 µM 0.0853020388182729 0.460302740641347 no 1505 0.466010635350138 491 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1698 5-fluorocytosine 1.055 µM 0.0842635614875835 0.460768724376969 no 1506 0.466423441525918 521 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2298 7976326 193.81 µM 0.0842289524885663 0.460784254997851 no 1507 0.466437199608647 515 2235818
SGTC_307 1501-1223 22.3 µM 0.0840257688151866 0.460875433894011 no 1508 0.466517971830997 513 2830329
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0839143961058394 0.460925413392475 no 1509 0.466562246747485 514 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2656 pseudo-anisatin 100 µM 0.0836678419806233 0.461036058953738 no 1510 0.46666026292412 514 6708809 A neurotoxin.
SGTC_1867 st057372 64 µM 0.0826933629973957 0.4614734032179 no 1511 0.467047681179693 480 688837
SGTC_2520 obtusaquinone 4.71 µM 0.0826374874907386 0.461498481453606 no 1512 0.467069896247773 528 5967872
SGTC_1990 st072050 59.8 µM 0.0823680265305481 0.46161942398955 no 1513 0.46717703038101 524 17233948
SGTC_414 piperonyl butoxide 100 µM 0.0820950638451293 0.461741941828475 no 1514 0.467285559178519 504 5794 A potent inhibitor of cytochrome P450.
SGTC_279 1273-0055 2.93 µM 0.0809089401952057 0.462274369089987 no 1515 0.467757185015269 511 2847562
SGTC_2539 epi(13)torulosol 80 µM 0.0804758759573263 0.462468779891415 no 1516 0.467929391095251 496 6708597
SGTC_3 0833-0587 95.581 µM 0.0798316708491869 0.462757992434121 no 1517 0.468185567503585 497 5382644
SGTC_2832 7992762 51.95 µM 0.0793113543326446 0.462991600216059 no 1518 0.468392487650437 511 2985177
SGTC_2775 cyproheptadine 69.59 µM 0.078663778476527 0.463282361754632 no 1519 0.468650028377416 520 2913 A selective serotonin reuptake inhibitor.
SGTC_1469 k284-2957 126 µM 0.0782723410237699 0.463458126680589 no 1520 0.468805709305802 503 23884841
SGTC_1820 st053765 18.6 µM 0.0781907973733056 0.463494742659595 no 1521 0.468838141119416 492 3690829
SGTC_601 0986-0029 62.9 µM 0.0772115128439119 0.463934500068753 no 1522 0.469227641532286 518 24747981
SGTC_2766 oltipraz 83.91 µM 0.077115717339236 0.463977520362977 no 1523 0.469265744802639 501 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2560 caryophyllene 100 µM 0.0768394258484625 0.464101600998033 no 1524 0.469375643073196 526 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_82 0054-0107 293.755 µM 0.0764834762220253 0.464261460706714 no 1525 0.469517229765307 521 3104697
SGTC_2288 7946289 167.31 µM 0.0761604597026801 0.464406534898472 no 1526 0.469645719935708 511 1246052
SGTC_15 0266-0086 27.098 µM 0.0760127867500834 0.464472859815222 no 1527 0.469704462637919 524 1712902 YIL048W NEO1
SGTC_2528 xanthyletin 44.79 µM 0.0757538910186179 0.464589141024461 no 1528 0.469807450148346 510 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1023 4482-3888 16 µM 0.0743154012126617 0.46523528348472 no 1529 0.470379711261296 517 3303168
SGTC_2165 5727197 32.143 µM 0.0739192848497921 0.465413227645294 no 1530 0.470537305368162 517 1361712
SGTC_2623 humulene 100 µM 0.0725253930864147 0.466039449157064 no 1531 0.471091898957744 499 6187145 An anti-inflammatory.
SGTC_1625 st003711 30.1 µM 0.071910851512096 0.466315565655932 no 1532 0.471336427075852 506 24207034 YER133W GLC7
SGTC_2974 9094440 9.66 µM 0.0711545554667127 0.466655395364961 no 1533 0.471637374588572 508 25236134
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0708218379614702 0.46680490444685 no 1534 0.471769775641687 523 7104
SGTC_3063 1327-0034 4 µM 0.0704854273243018 0.466956077827135 no 1535 0.471903649505578 516 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1249 0481-0015 10.2 µM 0.0699606352690708 0.467191913973305 no 1536 0.472112495668251 522 4227577
SGTC_1833 st055984 71 µM 0.0660427749922524 0.46895291838579 no 1537 0.473671885125751 500 676288
SGTC_3324 9138759 60.749 µM 0.065222297746303 0.469321785549553 no 1538 0.473998503945517 508 45595710
SGTC_251 melphalan 456.522 µM 0.0641253605319696 0.469814983657747 no 1539 0.474435204307522 515 460612 A DNA alkylator.
SGTC_2972 9093619 59.92 µM 0.0637486786503474 0.469984355750335 no 1540 0.474585171792769 475 25236256
SGTC_196 k015-0023 18.111 µM 0.0635449163789453 0.470075978143972 no 1541 0.474666296696286 525 5211998
SGTC_2139 5578692 56.4705 µM 0.0627502710543023 0.470433308191064 no 1542 0.474982682862942 516 650991 YMR113W FOL3
SGTC_1905 st060207 84.5 µM 0.0619685288497106 0.47078485929546 no 1543 0.475293947078309 511 1948547
SGTC_1100 amiodarone 5.07 µM 0.0618503371047113 0.470838012358579 no 1544 0.475341008488118 527 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_384 k007-0144 5.16 µM 0.0601953172203411 0.471582360244454 no 1545 0.476000037635235 522 6824886
SGTC_2506 ethyl hematommate 54.16 µM 0.0599104845224613 0.471710474299083 no 1546 0.476113464727418 489 3940691 An allergen.
SGTC_3267 9137951 49.47 µM 0.0592141104013481 0.472023706650512 no 1547 0.476390785444346 521 16643986
SGTC_164 4100-3994 89.624 µM 0.0588603168715618 0.472182851283536 no 1548 0.476531682885651 535 4615967
SGTC_2278 7948257 134.34 µM 0.0584348470118034 0.472374243491673 no 1549 0.476701129141257 525 1247028
SGTC_603 3794-0023 45.9 µM 0.0581039621728225 0.472523092242198 no 1550 0.476832909184924 512 3802260
SGTC_1932 st074806 40.9 µM 0.0577849987060942 0.472666581788641 no 1551 0.476959943754782 527 17251235
SGTC_2356 9061756 188.97 µM 0.0572808690215425 0.472893377808585 no 1552 0.477160729818697 504 20104043
SGTC_2988 9073640 71.4286 µM 0.0563760599524805 0.473300451997114 no 1553 0.477521114003935 519 9102229
SGTC_2457 5731572 11.68 µM 0.0554111988153355 0.473734574361493 no 1554 0.4779054370908 529 2865357
SGTC_1290 0986-0249 10.2 µM 0.0545223384735872 0.474134529116917 no 1555 0.478259505764713 525 53329
SGTC_1976 st070609 63.5 µM 0.0541486320298936 0.474302691203391 no 1556 0.478408373148484 528 682556
SGTC_316 k060-0003 58.6 µM 0.0526796725666659 0.4749637442 no 1557 0.478993567737252 512 6152314
SGTC_358 0075-0058 9.45 µM 0.0515306731504731 0.475480858685649 no 1558 0.479451330336358 527 1069125
SGTC_988 1497-1057 103 µM 0.0500393123834367 0.476152116540894 no 1559 0.480045530397097 530 3533044
SGTC_1965 Pectolinarigenin 58.4 µM 0.0491505596010734 0.476552174315446 no 1560 0.480399655665785 519 5320438 An anti-inflammatory.
SGTC_538 2922-0838 53.3 µM 0.0489547110400373 0.476640335588165 no 1561 0.480477693994322 498 777039
SGTC_1516 st013856 110 µM 0.0486743667978946 0.476766534598976 no 1562 0.48058940199368 521 5281404 A mutagen and neurotoxin.
SGTC_1946 st076057 65.1 µM 0.0483419036354082 0.476916198342227 no 1563 0.48072187965098 531 953009
SGTC_1448 4255-0083 152 µM 0.0479035267630774 0.477113545852291 no 1564 0.480896564334537 524 5399660
SGTC_2091 4-phenylthiadiazole 200 µM 0.0473542058254808 0.4773608458287 no 1565 0.48111546325137 529 270010
SGTC_1799 st045822 46.1415 µM 0.0467626052614314 0.477627189509275 no 1566 0.481351216544404 524 3674992
SGTC_2752 diclazuril 33.15 µM 0.0462407733919213 0.477862131020281 no 1567 0.481559172373879 521 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2625 euphol 100 µM 0.0461119410443386 0.477920135691485 no 1568 0.481610514278148 534 6708538 A triterpene alcohol.
SGTC_905 2-aminofluorene 215 µM 0.0449728297439295 0.478433022257218 no 1569 0.482064482879093 524 1539 An established DNA mutagen. YPR165W RHO1
SGTC_213 1246-0773 967 nM 0.0448968442072171 0.478467236138863 no 1570 0.482094766133883 528 6251622
SGTC_1661 st013063 9.66 µM 0.0448876065676358 0.478471395566346 no 1571 0.482098447707254 527 721395
SGTC_1455 4262-0120 131 µM 0.0446153625620941 0.47859397979328 no 1572 0.482206948649733 517 1529587
SGTC_3092 9117248 49.47 µM 0.0444307721700094 0.478677097084631 no 1573 0.482280516608427 539 17141857
SGTC_2451 5856223 45.7 µM 0.0437704046826924 0.478974454672608 no 1574 0.482543709053982 524 2179896
SGTC_480 am 92016 50 µM 0.0435346038351191 0.479080636534692 no 1575 0.482637690396289 527 2129 K+ channel blocker.
SGTC_2129 girgensonine 121.053 µM 0.0433139753403271 0.479179987583278 no 1576 0.482725625483617 538 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1027 k015-0025 8.67 µM 0.042308133806042 0.479632943613995 no 1577 0.48312653062701 515 3598955
SGTC_3049 9092223 49.47 µM 0.042216680297795 0.479674128768515 no 1578 0.483162982729836 524 8623917
SGTC_2549 cedrol 20.94 µM 0.0409920659676142 0.480225642073082 no 1579 0.483651110493995 526 6708665 A sedative which affects the nervous system.
SGTC_2911 7942208 15.64 µM 0.0406296480697739 0.480388866719119 no 1580 0.483795573961887 527 1243384
SGTC_1524 corynanthine 62.1 µM 0.0388401074831 0.481194882123541 no 1581 0.484508933899034 516 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_575 k072-0246 11.9 µM 0.0386183878779233 0.481294750837046 no 1582 0.484597320910635 530 6796779
SGTC_365 0121-0052 13.6 µM 0.0366130996442927 0.482198041321463 no 1583 0.485396749264215 532 3101739
SGTC_658 3253-0951 102 µM 0.0364543890274323 0.482269537147373 no 1584 0.485460023399018 531 1184878
SGTC_1917 st066507 28.5 µM 0.0363078347321143 0.482335557310149 no 1585 0.485518451423707 525 3156428
SGTC_985 1493-0307 8.71 µM 0.0358437148339785 0.482544638444835 no 1586 0.485703488024396 528 3278274
SGTC_2401 5128683 200 µM 0.0355929694207692 0.482657598618413 no 1587 0.485803457180413 527 708373
SGTC_2214 7179297 48.276 µM 0.0353907143314391 0.482748715038687 no 1588 0.485884094482609 531 769744
SGTC_2018 5133068 143 µM 0.0351301972065133 0.482866079977832 no 1589 0.485987961189419 535 785362
SGTC_1400 3771-8998 51.5 µM 0.0341981541617929 0.483285984519762 no 1590 0.486359569223537 522 670767
SGTC_2437 5741531 144.16 µM 0.0332518152022083 0.483712348630492 no 1591 0.486736889193936 536 2262990
SGTC_826 1683-5028 118 µM 0.0330651197645062 0.483796464717705 no 1592 0.486811328963568 520 722377
SGTC_517 1365-0151 113 µM 0.0329065282978069 0.483867919058513 no 1593 0.486874563393948 516 768657
SGTC_815 1582-0027 36.9 µM 0.0325056294382813 0.484048548759972 no 1594 0.487034413380466 537 3128206
SGTC_1215 3852-0577 11.2 µM 0.0312806388160863 0.484600502834973 no 1595 0.487522865419178 531 2884876
SGTC_3196 9111891 49.47 µM 0.0310738654084709 0.484693673365417 no 1596 0.487605315992206 534 18891510
SGTC_1378 2093-0007 380 nM 0.0308245609796326 0.484806009162429 no 1597 0.48770472644756 539 3618014
SGTC_802 4112-3352 742 µM 0.0305204238993605 0.484943054012958 no 1598 0.487826002525656 523 704594
SGTC_796 1234-0020 70.7 µM 0.0290172374619926 0.485620418999089 no 1599 0.488425421438078 538 46495034
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0284736475340332 0.485865381489766 no 1600 0.488642192863206 529 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1750 st081859 2.357 µM 0.0282029784323528 0.48598735737323 no 1601 0.488750130862489 535 5291695
SGTC_18 0111-0177 500 nM 0.0280942153270363 0.486036371375547 no 1602 0.488793503877159 535 721752
SGTC_259 usnic acid 108.925 µM 0.0280199195348799 0.486069852833366 no 1603 0.48882313194601 529 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3184 9108758 49.47 µM 0.0278007354512236 0.486168628886252 no 1604 0.488910539692644 536 902885
SGTC_2489 cantharidin 73.42 µM 0.0271037829852391 0.486482718495772 no 1605 0.489188478742276 538 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2434 5670830 169.91 µM 0.0268934759092275 0.486577497443589 no 1606 0.489272348553596 524 1549830
SGTC_3251 9135047 49.47 µM 0.0265698321149348 0.486723355252911 no 1607 0.489401417622953 533 17682963
SGTC_1040 k898-0338 155 µM 0.0252755520849697 0.487306671033367 no 1608 0.48991758715509 544 20969351
SGTC_706 4262-0057 46.9 µM 0.0251903356579507 0.487345077974987 no 1609 0.489951572769735 533 883298
SGTC_1875 nocodazole 6 µM 0.0249995366076712 0.487431071303539 no 1610 0.490027666613794 528 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2929 9013348 24.6 µM 0.0247347190441673 0.487550425819825 no 1611 0.490133280876551 533 2995952
SGTC_2438 5259590 200 µM 0.0238701134326655 0.487940115325971 no 1612 0.490478106756714 538 1201127
SGTC_3167 9103034 49.47 µM 0.0238479003756799 0.487950127206112 no 1613 0.490486965962402 532 5127859
SGTC_3185 9108267 49.47 µM 0.0232990698304028 0.488197498779508 no 1614 0.490705856840654 531 4910486
SGTC_2308 7584454 197.62 µM 0.0230185471943849 0.488323939066267 no 1615 0.490817739173433 535 893577
SGTC_2167 5876490 200 µM 0.0229269776662933 0.488365212558478 no 1616 0.490854260491478 539 686534
SGTC_2385 9074692 200 µM 0.0228974131049685 0.488378538335683 no 1617 0.490866051949512 536 17046906
SGTC_1135 dihydrocapsaicin 536.708 nM 0.0227131518916293 0.4884615915722 no 1618 0.490939542425065 533 107982 A Capsaicinoid.
SGTC_1407 3909-7909 12.3 µM 0.0224965424881842 0.488559225955133 no 1619 0.491025934999043 543 4411780
SGTC_888 0916-0002 6.97 µM 0.0221672075670928 0.488707671476973 no 1620 0.491157287865134 527 2802138 YIL048W NEO1
SGTC_128 0906-2981 13.371 µM 0.021573290609822 0.488975379529557 no 1621 0.491394169788946 531 6740226
SGTC_2551 apiole 73.87 µM 0.0209054407598531 0.489276418758539 no 1622 0.491660543237382 539 10659 A possible DNA adduct former.
SGTC_2000 st075254 36.4 µM 0.0208919695142717 0.489282491105111 no 1623 0.491665916313325 532 17234175
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0208766273964177 0.489289406775749 no 1624 0.491672035598187 538 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2089 5281248 129.67 µM 0.0206733205929184 0.489381050416968 no 1625 0.491753125776726 528 2737878
SGTC_2800 7887935 81.82 µM 0.0206434649454443 0.48939450835256 no 1626 0.491765033915528 534 2961002
SGTC_2408 sulbentine 18.36 µM 0.0202080549296558 0.489590778109687 no 1627 0.491938701146988 513 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3212 9128307 49.47 µM 0.0199532227368106 0.489705649980449 no 1628 0.492040343987954 523 27243542
SGTC_2917 7979103 53.79 µM 0.0199456851656924 0.489709047738836 no 1629 0.492043350445449 540 2980565
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0191730889590247 0.490057319712073 no 1630 0.492351512777892 539 16725076
SGTC_683 panaxydol 45 µM 0.019053981925827 0.490111011624253 no 1631 0.492399020930496 535 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_41 0478-0632 82.643 µM 0.018575059736461 0.490326905360463 no 1632 0.492590049425314 539 3750424
SGTC_1849 st056239 19.2 µM 0.0178462603425737 0.490655446868299 no 1633 0.492880750104775 539 5393181
SGTC_1277 0873-0036 22 µM 0.0171270669414191 0.490979664227324 no 1634 0.493167622890278 531 5965735
SGTC_2930 9013230 14.89 µM 0.016889029797015 0.49108697434147 no 1635 0.493262572237094 535 2995857
SGTC_2662 daunorubicin 22.37 µM 0.0165644789146977 0.491233286965798 no 1636 0.493392031194065 531 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1767 st044992 70.3 µM 0.0154016645908125 0.491757511432331 no 1637 0.493855867716696 543 9600693
SGTC_600 1495-0418 41.6 µM 0.0151944412030938 0.49185093420489 no 1638 0.493938528214296 538 5377768
SGTC_2589 lobaric acid 100 µM 0.0151222254015155 0.491883491448065 no 1639 0.49396733484114 539 73157 A novel microtubule depolymerizer.
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0147435734050488 0.492054201021445 no 1640 0.494118378289546 543 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2166 5933061 31.504 µM 0.0141918260539379 0.492302950636022 no 1641 0.494338470597769 534 2877375
SGTC_1430 4049-0248 69.1 µM 0.014178922745356 0.492308767996088 no 1642 0.494343617755226 541 22774488
SGTC_2671 danthron 100 µM 0.0134995124836787 0.492615077306398 no 1643 0.494614637274529 537 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_818 4072-2707 53.5 µM 0.0127063095231248 0.492972695081973 no 1644 0.494931052300914 539 882871
SGTC_2941 9056145 11.23 µM 0.0120062189664718 0.493288337571397 no 1645 0.495210326698131 541 2119517
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.0118824345704901 0.493344147387077 no 1646 0.495259706004787 541 88881 An O-methylated flavonoid and antioxidant.
SGTC_1381 2324-0066 62.1 µM 0.0117229837239354 0.493416038080835 no 1647 0.495323313258531 540 10885928
SGTC_1924 st058459 75.1 µM 0.0100282576409423 0.494180142315743 no 1648 0.495999371082891 544 688683
SGTC_1726 st035556 14.5795 µM 0.00982787637091079 0.494270490049969 no 1649 0.496079307703939 529 5919439
SGTC_848 0368-0089 85.6 µM 0.00910704368623248 0.494595500866237 no 1650 0.496366865445135 546 762535
SGTC_2867 9039098 71.43 µM 0.00846416911485295 0.494885364769408 no 1651 0.496623325390375 536 6463460
SGTC_1739 st037196 92.5 µM 0.0078177609441467 0.495176824649681 no 1652 0.496881196390195 541 612214
SGTC_2738 aclarubicin 5.55 µM 0.00761803939483771 0.495266877905063 no 1653 0.496960871387394 542 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3201 9113999 49.47 µM 0.00734391307053027 0.495390480221506 no 1654 0.497070228907849 539 16649224
SGTC_2225 6654152 15.4 µM 0.00663861760245744 0.495708496754831 no 1655 0.497351594208066 541 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2024 5144227 134 µM 0.00662099462429328 0.495716442961635 no 1656 0.497358624604653 543 3475211
SGTC_345 1362-0200 395 µM 0.00603553239953955 0.495980429023311 no 1657 0.497592185559604 538 1419823
SGTC_1581 himbacine 57.9 µM 0.00593969454784769 0.496023642668713 no 1658 0.497630418645329 537 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2084 5306078 60.6385 µM 0.00579392192540513 0.496089372178105 no 1659 0.497688572506874 542 679340
SGTC_941 3237-0776 460 µM 0.00518066385960079 0.496365894048787 no 1660 0.497933223390994 546 760008
SGTC_2098 5376439 882.5 nM 0.00381064425258211 0.496983650508568 no 1661 0.498479776571274 545 2844116
SGTC_2362 9071156 126 µM 0.00292618644953131 0.497382465904644 no 1662 0.498832622170903 548 653133
SGTC_2896 9052656 71.43 µM 0.00287995778863127 0.497403311182206 no 1663 0.498851064660585 548 6469436
SGTC_2793 7325131 81.82 µM 0.00274036399238649 0.497466256406018 no 1664 0.498906754308053 547 4176441
SGTC_1233 0325-0408 14.2 µM 0.00265032366664377 0.497506857158299 no 1665 0.49894267507044 545 12874
SGTC_840 0245-0196 390 µM 0.00191155720598957 0.497839980769107 no 1666 0.499237399473555 546 3827528
SGTC_2323 6148992 148.28 µM 0.00186944489423836 0.497858970045479 no 1667 0.499254199825215 546 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1787 fluconazole 80 µM 0.00157256764687242 0.49799283801798 no 1668 0.499372636535446 546 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1744 st037937 38.9 µM -0.000602512564083826 0.498973631727165 no 1669 0.499759632278257 549 1016152
SGTC_2939 9044578 71.43 µM -0.000931568851870069 0.499122011464222 no 1670 0.499628357851637 548 2653634
SGTC_3147 9097027 49.47 µM -0.000954280663655951 0.499132252794771 no 1671 0.499619297153679 548 25236841
SGTC_325 2810-4341 181 µM -0.00123112512726632 0.499257089011603 no 1672 0.499508852258338 549 774970
SGTC_2111 5486399 200 µM -0.00128109252123586 0.499279620589771 no 1673 0.499488918167971 549 689674
SGTC_3019 9081971 49.47 µM -0.00140336405687182 0.499334755967482 no 1674 0.499440138926686 548 16451803
SGTC_2161 5662504 8.5105 µM -0.00172219489394521 0.499478525042758 no 1675 0.499312943981343 549 2859334
SGTC_1711 st032263 62.8 µM -0.00177870780708046 0.499504008185357 no 1676 0.499290398625448 551 3958979
SGTC_2735 sertaconazole 140 nM -0.00212601767637285 0.499660619280482 no 1677 0.499151842298953 548 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1467 k284-1082 293 µM -0.00226428111850665 0.499722965895209 no 1678 0.499096683298993 550 3334705
SGTC_1214 0358-0031 63.7 µM -0.00349301440878962 0.499722965895209 no 1679 0.498606491700017 554 4301366
SGTC_2753 fluvastatin 17.09 µM -0.00444759100945181 0.499292522473155 no 1680 0.498225673750076 554 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_515 4092-1064 102 µM -0.00460730449436119 0.499220503574793 no 1681 0.498161957941283 553 717353
SGTC_1146 3579-1023 7 µM -0.0064436993120941 0.498392428562609 no 1682 0.497429353691637 551 X1146
SGTC_1896 st058441 89 µM -0.00713256239667101 0.498081805066417 no 1683 0.497154543418751 551 688759
SGTC_1876 myriocin 605 nM -0.00717793313659094 0.498061346441948 no 1684 0.497136443575645 551 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3220 9131269 49.47 µM -0.00723330083132084 0.498036379986418 no 1685 0.497114355634672 553 17722206
SGTC_2049 5262831 67.185 µM -0.00755347553192261 0.497892006648438 no 1686 0.496986627901019 551 763417
SGTC_1376 2910-0861 41.3 µM -0.00782004923035121 0.497771803311288 no 1687 0.496880283523983 553 1112859
SGTC_67 0335-0847 266 µM -0.00869129542278139 0.497378942691687 no 1688 0.496532718436723 561 4552207 YOR254C SEC63
SGTC_608 k048-0125 159 µM -0.00952383978708025 0.497003535793994 no 1689 0.496200595073821 553 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2276 7947513 42.08 µM -0.00995735866365694 0.496808056578249 no 1690 0.4960276542704 571 2105100
SGTC_61 0978-8327 98.565 µM -0.0118204943867626 0.495967954121912 no 1691 0.495284414827601 563 6150059 YHR072W ERG7
SGTC_489 paxilline 115 µM -0.0129572141701536 0.495455406833942 no 1692 0.494830964069437 562 105008 A toxic potassium channel blocker.
SGTC_669 0108-0021 26.2 µM -0.0138844262282836 0.495037332158386 no 1693 0.494461093301567 565 17201
SGTC_3141 9094609 49.47 µM -0.0140184666949376 0.49497689450979 no 1694 0.494407624096127 554 25236309 YDL196W YDL196W
SGTC_552 k242-0005 476 µM -0.0144389903565879 0.494787284903328 no 1695 0.494239876410503 555 4088318
SGTC_1262 0737-0114 49.6 µM -0.0154282795718765 0.494341229732138 no 1696 0.493845251136896 553 765919
SGTC_1261 0712-0010 12.7 µM -0.0155225386319364 0.494298730143557 no 1697 0.493807651715121 563 2840123
SGTC_2361 9034121 116 µM -0.0155597637947828 0.494281946054821 no 1698 0.493792802817084 563 6496917
SGTC_855 0428-0020 25 µM -0.0159929790969754 0.494086618606389 no 1699 0.49361999642444 555 6812414
SGTC_993 3909-8757 62.7 µM -0.0172213691904614 0.493532771837729 no 1700 0.493130007283853 556 4288324 YLR208W SEC13
SGTC_2279 7948423 32.93 µM -0.0176516620629791 0.493338767698649 no 1701 0.492958371358771 553 1247112
SGTC_2022 5136654 200 µM -0.0178213974665636 0.493262240320243 no 1702 0.49289066738003 558 1713771
SGTC_1904 st060225 78 µM -0.0181652002957119 0.493107233178676 no 1703 0.492753532097211 551 66595
SGTC_2432 5630864 12.22 µM -0.0185940155992517 0.49291389872528 no 1704 0.492582488436024 563 5714970
SGTC_2233 sulbentine 40.3845 µM -0.0186210191435972 0.492901724038984 no 1705 0.492571717445298 555 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1961 st076550 68.7 µM -0.0193614283108072 0.492567909388157 no 1706 0.492276390192583 558 1579337
SGTC_725 1497-0963 19 µM -0.0236145051691361 0.490650510895637 no 1707 0.490580050963094 557 3549977
SGTC_1520 flindersine 88 µM -0.0238659398445989 0.490537163883714 no 1708 0.490479771303255 565 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1299 1079-1439 3.74 µM -0.0240111772849893 0.49047169104287 no 1709 0.490421846547039 562 323161
SGTC_1447 4239-0816 81.9 µM -0.0244340459498149 0.490281063891512 no 1710 0.490253195842725 559 1341554
SGTC_2768 sulfasalazine 50.2 µM -0.0245141800362873 0.490244940081304 no 1711 0.490221236540499 565 5384001 An antioxidant and salicylic acid derivative.
SGTC_2412 st077135 33.4 µM -0.0246251376397207 0.49019492140644 no 1712 0.490176984220054 596 13258915
SGTC_1973 st070275 50.2 µM -0.0256916943835717 0.489714135340984 no 1713 0.489751624296851 556 17118334
SGTC_1306 1185-0270 9.02 µM -0.0266940357220583 0.489262310123534 no 1714 0.489351885121549 567 1548076
SGTC_1336 1486-0901 104 µM -0.0268476797271133 0.489193053247655 no 1715 0.489290611992374 560 5006114
SGTC_1427 4048-4900 550 nM -0.0271206905952769 0.489069991133514 no 1716 0.48918173606041 558 24132586
SGTC_415 dibenzyl ketone 100 µM -0.0276112756851762 0.488848858096899 no 1717 0.488986094199397 561 7593
SGTC_1412 3909-8563 178 µM -0.0279264337135097 0.488706801258687 no 1718 0.488860412803796 571 23767530
SGTC_721 1187-1332 279 µM -0.0281488025770792 0.488606569808156 no 1719 0.488771735324346 561 25730
SGTC_739 1486-1183 203 µM -0.0296305802260106 0.487938685971973 no 1720 0.488180838261088 565 4346692
SGTC_424 splitomicin 100 mM -0.0297588912367022 0.487880853724358 no 1721 0.488129672137455 580 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1621 st003705 32.4 µM -0.0305198240253681 0.487537891916105 no 1722 0.487826241729322 568 24207032
SGTC_69 0096-0274 206.684 µM -0.0322195840001297 0.486771822759059 no 1723 0.487148469256286 567 6741392
SGTC_2495 cafestol 54.53 µM -0.0322878611951724 0.486741051736745 no 1724 0.487121244760942 585 16667697 An anti-infammatory.
SGTC_1084 voriconazole 435 nM -0.0323184822434828 0.486727251532879 no 1725 0.487109035102122 565 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1394 3474-0001 65.7 µM -0.0337927694668591 0.486062843220391 no 1726 0.486521200891911 560 5017666 YIL048W NEO1
SGTC_2710 st078562 53.7235 µM -0.0346634150753576 0.485670492558859 no 1727 0.486174066962475 567 17250908
SGTC_1502 4534-4282 27.7 µM -0.0362527184557471 0.484954319585854 no 1728 0.485540425170361 563 3278949
SGTC_1882 5615643 20 µM -0.0368777257337828 0.484672691547234 no 1729 0.485291249976881 566 2253075
SGTC_291 SEC14.278 35.5 µM -0.0370660017407729 0.484587855943112 no 1730 0.485216190035372 565 1068044
SGTC_1916 st067606 49.2 µM -0.0374733789417638 0.484404297554661 no 1731 0.485053782880316 570 19590279
SGTC_537 1334-0398 209 µM -0.0375472522147054 0.48437101165857 no 1732 0.485024332434383 585 5846986
SGTC_891 0929-0073 133 µM -0.0379672672917905 0.484181762905504 no 1733 0.484856890059324 581 5603632
SGTC_2837 9008476 45.46 µM -0.0381350125001989 0.484106181917976 no 1734 0.48479001783275 570 2992805
SGTC_286 k060-0067 22.9 µM -0.0384061766740285 0.483984004638233 no 1735 0.484681918171662 569 5985051
SGTC_1893 st059353 36.1 µM -0.0385299847732238 0.483928221452893 no 1736 0.484632562417936 575 3112488
SGTC_2421 5690543 90.72 µM -0.0386697953465879 0.483865228544129 no 1737 0.484576827605574 561 3397993
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.039378878350153 0.483545751065639 no 1738 0.484294159740307 563 1241132 A phosphatase inhibitor.
SGTC_1236 0330-0013 258 µM -0.039582778419452 0.483453885798241 no 1739 0.484212878754312 585 4617066
SGTC_1087 pterostilbene 9.05 µM -0.0397192001483031 0.483392422755563 no 1740 0.484158497124982 567 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2591 skatole 100 µM -0.0402238621072208 0.48316505728925 no 1741 0.483957326905774 569 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1206 3978-0017 132 µM -0.0413132670143623 0.482674266211921 no 1742 0.483523078276368 585 3873677
SGTC_2910 7948405 25.97 µM -0.0418613019068293 0.482427379245198 no 1743 0.483304632971879 563 2971328
SGTC_337 1315-0038 354 µM -0.0440486409264673 0.481442062060616 no 1744 0.482432815807953 570 1626437
SGTC_3305 9127027 53.8275 µM -0.0448630058092743 0.48107524874605 no 1745 0.4821082521129 577 41905295
SGTC_3233 9132340 49.47 µM -0.04548545327162 0.480794891332634 no 1746 0.481860184752917 592 17682950
SGTC_2231 micatex 6.853 µM -0.0455242099072035 0.480777435216067 no 1747 0.481844739092205 577 20737 An antifungal of unknown mechanism.
SGTC_1379 2144-0755 36.5 µM -0.0457113509888764 0.480693146774599 no 1748 0.481770158243517 571 5392327
SGTC_72 0744-0168 198.391 µM -0.045997153869477 0.480564422674103 no 1749 0.481656259196715 580 677577
SGTC_1979 st071809 45.3 µM -0.0460234968693036 0.480552558028604 no 1750 0.481645760978277 596 4976333
SGTC_2190 6049624 200 µM -0.0477478536034633 0.479775961535012 no 1751 0.480958597954539 563 2265554
SGTC_1070 indatraline 8.81 µM -0.0481687267619227 0.479586424932299 no 1752 0.480790886836705 565 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_147 4466-0538 29.23 µM -0.0492574123560473 0.479096166266578 no 1753 0.480357079154829 602 6742687 YHR072W ERG7
SGTC_342 k048-0088 23.3 µM -0.0496186429145577 0.478933503285498 no 1754 0.48021314501642 564 6820570
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0503717270414842 0.478594399022843 no 1755 0.479913083164081 563 551469
SGTC_1109 tnp00067 928.257 nM -0.053271279187221 0.477288914197814 no 1756 0.478757881793157 567 676295
SGTC_2239 6685329 187.64 µM -0.0538031830445065 0.477049457591844 no 1757 0.478545986746086 583 805680
SGTC_571 k831-0106 44.2 µM -0.0539963328172838 0.476962505974661 no 1758 0.478469042984499 569 4783639
SGTC_654 1124-0271 80.9 µM -0.0549610753758994 0.47652821740748 no 1759 0.478084737122699 569 5403748
SGTC_1272 0839-0021 27 µM -0.0563984262412671 0.475881231320898 no 1760 0.477512205319622 589 5027250
SGTC_967 1306-0166 352 µM -0.0566446688873982 0.475770397934282 no 1761 0.477414125509348 567 4437607
SGTC_354 2783-3500 4.88 µM -0.0573139454372956 0.475469167220405 no 1762 0.4771475558807 573 6740761
SGTC_1066 ketoconazole 628 nM -0.0580704941511745 0.475128673586886 no 1763 0.476846238487447 568 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1445 4239-0156 97.7 µM -0.0583718864285553 0.474993033498371 no 1764 0.476726203978872 610 4008346
SGTC_2885 9057732 51.95 µM -0.0591683151280031 0.4746346187315 no 1765 0.476409023138335 594 6471414
SGTC_1649 st011737 51.3 µM -0.0593747640461576 0.474541714392451 no 1766 0.476326806481501 573 1761035
SGTC_152 4469-0003 551.229 µM -0.0611138029451254 0.473759182736666 no 1767 0.475634288269189 584 697280
SGTC_2734 clemastine 41.6 µM -0.0611728161922459 0.473732629751043 no 1768 0.475610789356286 578 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1169 aniline yellow 25.8 µM -0.0613535419484007 0.473651312999828 no 1769 0.475538825384654 595 6051 A DNA damaging agent.
SGTC_516 3992-2719 87.3 µM -0.0615734520888319 0.473552366890044 no 1770 0.475451259489765 572 5350887 YDR037W KRS1
SGTC_1052 3253-3998 198 µM -0.062160557216344 0.473288213509473 no 1771 0.475217486249689 594 5450317
SGTC_1191 1487-1166 10.6 µM -0.0624149718241129 0.473173749612024 no 1772 0.475116186207108 569 3955771
SGTC_226 1,3-diallylurea 8.28947 mM -0.0628005486060748 0.47300027865211 no 1773 0.474962664504366 574 74537 YKL182W FAS1
SGTC_1345 1488-0192 31.4 µM -0.0628438492770986 0.472980798003265 no 1774 0.474945424090271 584 658348
SGTC_1080 nisoldipine 24.4 µM -0.0632177361285862 0.472812591791184 no 1775 0.474796560819906 582 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2085 5307070 144.047 µM -0.0634989803151648 0.472686067348946 no 1776 0.474684585598867 598 2840351
SGTC_1494 4358-1428 177 µM -0.0645892836102499 0.472195594429891 no 1777 0.474250508666922 599 1564571
SGTC_1106 tegaserod maleate 11.7 µM -0.0648308809081901 0.472086917569453 no 1778 0.474154326876695 586 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1395 3486-0190 4.35 µM -0.0663244513146485 0.471415116504977 no 1779 0.473559758373605 589 6748079
SGTC_248 streptozotocin 5.23457 mM -0.0664616982075172 0.471353387538097 no 1780 0.473505125330352 585 5300 DNA alkylating agent.
SGTC_2712 st079126 47.7 µM -0.06718455483701 0.471028282696436 no 1781 0.473217390397861 593 3152970
SGTC_3334 9142812 21.919 µM -0.0685924098333512 0.470395155384528 no 1782 0.472657030356894 588 45283678
SGTC_862 0452-0056 10.2 µM -0.0686385024700552 0.470374428293678 no 1783 0.472638685291195 570 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2870 9038528 12.99 µM -0.0693064821521779 0.470074057997192 no 1784 0.47237283306786 612 6463316
SGTC_1607 st000305 50.6 µM -0.0693981964681684 0.470032818163798 no 1785 0.472336332235025 599 5457690
SGTC_845 0330-0138 4.51 µM -0.0702208472900137 0.469662923240313 no 1786 0.472008940771876 577 9039800
SGTC_2072 5231554 129 µM -0.0707299042041806 0.469434045090182 no 1787 0.471806360159587 575 789545
SGTC_146 3448-8650 53.125 µM -0.0708581989434811 0.469376363813014 no 1788 0.471755306060603 610 2891488 YIL048W NEO1
SGTC_117 lucigenin 22.078 µM -0.0708714598084883 0.469370401768624 no 1789 0.471750029007741 612 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1280 0880-0253 10.1 µM -0.0708827145393502 0.469365341681404 no 1790 0.471745550283459 600 6836607
SGTC_1611 st001856 99.4 µM -0.0719895529368021 0.468867735348866 no 1791 0.471305110914262 578 647478
SGTC_773 4358-1457 44.6 µM -0.0724463307699761 0.468662393808204 no 1792 0.471123357505144 606 1186886
SGTC_931 2812-0076 566 µM -0.0727122410452866 0.468542859387595 no 1793 0.471017553695314 585 3450959
SGTC_990 3985-0011 41.3 µM -0.0735592771172476 0.468162110936461 no 1794 0.470680537731672 597 5399565 YGL099W LSG1
SGTC_541 4513-1321 94 µM -0.0735971966280905 0.468145066537964 no 1795 0.470665450929009 568 747515
SGTC_220 paclitaxel 373.376 µM -0.0738768212801947 0.468019380171009 no 1796 0.470554199689129 607 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_449 xestospongin c 11.1929 µM -0.0758414958582115 0.467136384067044 no 1797 0.469772601126675 588 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2318 6029776 164 µM -0.0765106549786179 0.466835676355848 no 1798 0.46950641868863 588 818325
SGTC_975 1335-0046 28.5 µM -0.0766428983623922 0.466776250863877 no 1799 0.469453815670025 600 16486740
SGTC_1442 4112-3290 3 µM -0.0769719628674773 0.466628384149396 no 1800 0.469322924584754 581 704353
SGTC_1618 st003135 44.5 µM -0.0777077480025605 0.466297772261663 no 1801 0.469030265365521 580 1270615
SGTC_293 4049-0273 38.5 µM -0.0778247145529297 0.466245217571087 no 1802 0.468983743349074 576 1380311
SGTC_2252 omeprazole 400 µM -0.0789255163292477 0.465750641052516 no 1803 0.468545933724809 600 4594 A proton pump inhibitor.
SGTC_1139 k015-0024 46.9 µM -0.0803343090691509 0.46511776529631 no 1804 0.467985685845786 607 2766652
SGTC_402 epigallocatechin gallate 10 µM -0.0812171912537342 0.464721190622853 no 1805 0.467634614018375 601 65064 An antioxidant.
SGTC_2466 5983409 37.09 µM -0.0831365582299656 0.463859167192001 no 1806 0.466871478593347 604 2879657
SGTC_2321 7390090 138.78 µM -0.0835272716817998 0.46368371115861 no 1807 0.466716146744598 595 649046
SGTC_2722 naftopidil 47.16 µM -0.0835489714340232 0.463673966749598 no 1808 0.46670751995009 598 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2582 agaric acid 100 µM -0.0837127450320736 0.463600423897751 no 1809 0.46664241182311 586 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2956 9076196 2.52 µM -0.0844483875220884 0.463270097588485 no 1810 0.466349968486462 593 16423868
SGTC_623 k072-0108 16.9 µM -0.0849990580445272 0.463022845993507 no 1811 0.466131069786173 606 5382803
SGTC_203 k066-0004 30.888 µM -0.0853860522699238 0.462849093754636 no 1812 0.465977240670728 574 6795412
SGTC_2711 st079103 59.1 µM -0.0868218118133505 0.462204530211574 no 1813 0.465406574884788 601 54693780
SGTC_742 0kpi-0133 140 µM -0.0872375312137269 0.462017917434637 no 1814 0.465241353732705 596 2728852
SGTC_1940 st075990 51.1 µM -0.0891877967859109 0.461142572685533 no 1815 0.464466331740762 604 1084979
SGTC_1344 1488-0097 29.1 µM -0.0899284957226309 0.460810171193232 no 1816 0.464172018288705 575 747966
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.0901031103255063 0.460731813841896 no 1817 0.464102638796726 602 16486 A toxic proline analog.
SGTC_29 0299-0004 12.984 µM -0.0905291430543848 0.4605406403811 no 1818 0.463933368110099 593 16871 A napthoquinone isolated from Swertia calycina.
SGTC_26 0302-0163 425.158 µM -0.0906980092747567 0.460464867645017 no 1819 0.463866276240948 598 3100915
SGTC_2336 9001819 198.65 µM -0.0909022616344519 0.460373218550714 no 1820 0.463785126555366 576 2989602
SGTC_626 0214-0009 33 µM -0.0915972721104492 0.460061379539202 no 1821 0.463509009440294 607 3437874
SGTC_2858 9025781 8.96 µM -0.0928843337409559 0.459483962566798 no 1822 0.462997725900405 610 4894980 YPL153C RAD53
SGTC_661 1304-0007 33.6 µM -0.0934372594314465 0.459235928604446 no 1823 0.462778095616625 595 3117130
SGTC_2038 4100038 30.985 µM -0.0940496389811493 0.458961243076565 no 1824 0.462534862623428 605 3596803
SGTC_500 h-89 112 µM -0.0942626708328368 0.45886569129363 no 1825 0.462450251100079 612 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2340 7987427 183.45 µM -0.0963273869863828 0.457939722238096 no 1826 0.46163028027574 587 2239331
SGTC_139 0099-0334 718.624 µM -0.0964036255907661 0.457905535635477 no 1827 0.461600006366368 593 97690
SGTC_2840 9008771 71.43 µM -0.0972052884834963 0.457546076147909 no 1828 0.461281684167104 571 2992978
SGTC_3089 9117425 49.47 µM -0.0979266262839615 0.457222663487329 no 1829 0.460995278440085 590 9401657
SGTC_2984 9022109 38.96 µM -0.0980728613863131 0.457157102251929 no 1830 0.460937218547549 601 6459207
SGTC_2488 5268135 45.7 µM -0.099876076650439 0.456348767428467 no 1831 0.460221354716946 604 1270356 YLR208W SEC13
SGTC_2227 7312221 64.1025 µM -0.101435839283168 0.455649711690228 no 1832 0.459602243774164 581 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_850 0388-0143 75.9 µM -0.101973551725902 0.455408750983938 no 1833 0.459388834145836 593 67273
SGTC_1433 4060-0023 7.6 µM -0.102440911738931 0.455199330061264 no 1834 0.459203355795548 586 3840627
SGTC_3344 9148862 3.898 µM -0.102539805252127 0.455155018127685 no 1835 0.459164109660214 620 4905352
SGTC_3054 9094397 49.47 µM -0.103148906212489 0.454882106165685 no 1836 0.458922395226047 613 2598354
SGTC_2334 9017922 200 µM -0.103590623009976 0.45468420516632 no 1837 0.45874711469032 593 3163164
SGTC_629 3448-6466 76.7 µM -0.104690603708234 0.454191433227808 no 1838 0.458310659071572 602 573744
SGTC_3095 9117207 49.47 µM -0.104845996987007 0.454121825447444 no 1839 0.458249005420325 586 17015229
SGTC_2226 7298446 200 µM -0.104997938594547 0.45405376519149 no 1840 0.458188722221269 595 3283010
SGTC_3297 9117502 71.43 µM -0.106146618634392 0.453539272785338 no 1841 0.457733011862244 592 7453720
SGTC_1213 1315-0166 115 µM -0.106933444019509 0.453186899584477 no 1842 0.457420890403814 608 768401
SGTC_1138 3761-0006 1.03 µM -0.107394803519666 0.452980300695372 no 1843 0.457237888428068 596 12061087
SGTC_3079 9117512 49.47 µM -0.107675584089858 0.45285457210123 no 1844 0.457126518980631 602 7185044
SGTC_1749 st037932 54.2 µM -0.107779462251071 0.452808058487263 no 1845 0.457085317362019 611 594497
SGTC_274 sirtinol 40.1 µM -0.108427733193077 0.4525177963029 no 1846 0.456828201454585 587 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2418 pentamidine 31.67 µM -0.10879845852564 0.452351816075509 no 1847 0.456681173240081 612 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1327 1436-0082 2.18 µM -0.10891088567094 0.452301482116703 no 1848 0.456636586245687 600 15992205
SGTC_3354 9151612 71.43 µM -0.109058160638157 0.452235547846968 no 1849 0.456578179930686 606 27261949
SGTC_1507 4075-3230 155 µM -0.109276583747706 0.452137763334096 no 1850 0.456491559408998 585 659771
SGTC_1715 st032160 10.2275 µM -0.10955710656223 0.452012182041718 no 1851 0.456380314907242 598 5289825
SGTC_419 nsc-638432 893 µM -0.111476737327934 0.451152952864999 no 1852 0.455619155766076 615 368090
SGTC_2341 7987486 176.74 µM -0.112203615527018 0.450827660765941 no 1853 0.455330981249504 592 1258686
SGTC_2034 5197015 53.07 µM -0.112456856765971 0.45071433814319 no 1854 0.455230587999772 620 780676
SGTC_506 n9-isopropylolomoucine 153 µM -0.112820912460115 0.450551434332352 no 1855 0.455086269225378 581 6610355
SGTC_383 2324-0395 7.37 µM -0.113273725692268 0.450348825859373 no 1856 0.454906773506101 613 3146421
SGTC_1346 1488-2224 62.4 µM -0.11343410739658 0.450277067160608 no 1857 0.454843200208282 610 3722427
SGTC_1399 3562-5772 25 µM -0.114423878915869 0.449834255223985 no 1858 0.454450892835544 586 23847490
SGTC_2203 7227154 166.4 µM -0.115442284308615 0.449378698031559 no 1859 0.454047282474358 597 896304
SGTC_1343 1487-0095 224 µM -0.116567516249142 0.448875432361463 no 1860 0.453601390234102 624 4560101 YGL055W OLE1
SGTC_1868 st057644 42.7 µM -0.117295957430262 0.448549677168673 no 1861 0.453312764211087 602 688665
SGTC_371 0195-0006 7.36 µM -0.118185385886821 0.448151976337123 no 1862 0.452960384586215 594 3928593
SGTC_1362 1611-0397 101 µM -0.118201994582985 0.448144550385618 no 1863 0.452953804794991 590 27816
SGTC_2331 7980721 200 µM -0.118639506478208 0.447948940009937 no 1864 0.452780482365115 613 2981221
SGTC_352 k048-0007 5.11 µM -0.119004418434364 0.447785798547725 no 1865 0.452635927627851 619 6811911
SGTC_2689 tacrolimus 100 µM -0.119877261806252 0.447395611685696 no 1866 0.45229018850708 595 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1424 4048-1941 275 µM -0.120050631338634 0.447318116413028 no 1867 0.452221519969017 593 X1424
SGTC_1324 1418-0026 34.4 µM -0.121394780655568 0.446717357177638 no 1868 0.451689175370851 633 1372513
SGTC_263 alizarin 107.927 µM -0.122707976224953 0.446130550584383 no 1869 0.451169173744984 602 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_989 1501-0895 10.3 µM -0.123054889615927 0.445975550619509 no 1870 0.451031816289273 600 2830112
SGTC_1658 st012944 20 µM -0.123578138354296 0.44574178012243 no 1871 0.450824651424504 628 24207260
SGTC_2188 6126565 140.678 µM -0.124300399332707 0.445419128440355 no 1872 0.450538715566277 616 874518
SGTC_555 4296-0685 37 µM -0.124722882668551 0.445230411522206 no 1873 0.450371470551871 605 2908540 YHR072W ERG7
SGTC_1778 st046819 58.9 µM -0.124743317480077 0.445221283915197 no 1874 0.450363381413762 584 671715
SGTC_912 3474-0017 2.18 µM -0.125120577864309 0.445052778430648 no 1875 0.450214046266789 613 3360550
SGTC_630 4356-0227 183 µM -0.125271463168711 0.444985387433631 no 1876 0.450154321641529 624 779312
SGTC_88 0180-0332 8.668 µM -0.12534560103489 0.444952275283591 no 1877 0.450124976213241 594 3101745
SGTC_550 4123-0385 25.7 µM -0.125834169413042 0.444734075902668 no 1878 0.449931596731548 629 5731123
SGTC_1648 st011736 69.8 µM -0.12633012871142 0.444512592792881 no 1879 0.449735304021031 603 2855514
SGTC_2250 alverine citrate 130 µM -0.127375802415351 0.444045677728725 no 1880 0.449321483550396 593 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3046 9092212 49.47 µM -0.127719081180622 0.443892413517009 no 1881 0.449185644581654 589 25236637
SGTC_1841 st054148 70 µM -0.128057706973973 0.443741234946233 no 1882 0.449051652677054 646 675442
SGTC_86 0417-1630 471.922 µM -0.128716750439723 0.44344703026282 no 1883 0.448790890368235 600 3634867
SGTC_2904 7225135 42.03 µM -0.129152485227805 0.443252530282832 no 1884 0.448618496263008 612 4446116
SGTC_684 1140-0066 328 µM -0.129491550760813 0.443101190245847 no 1885 0.448484355090531 628 6813534
SGTC_1323 1348-1351 11.2 µM -0.12975993698454 0.442981403414309 no 1886 0.44837818025539 597 6989654
SGTC_903 1134-0042 114 µM -0.129865822281249 0.442934145848582 no 1887 0.44833629255755 605 701009
SGTC_664 1222-0054 14.9 µM -0.129896450989273 0.44292047613048 no 1888 0.448324176100058 596 6813991
SGTC_2291 7917025 104.35 µM -0.135060799149324 0.440616590687799 no 1889 0.446281901935881 606 2964612
SGTC_184 1494-0393 24.714 µM -0.135640436876072 0.440358130414715 no 1890 0.446052768423425 615 3090647
SGTC_1865 st057639 52.2 µM -0.135719432448912 0.440322908279581 no 1891 0.446021542496057 602 688818
SGTC_2068 5226020 147 µM -0.135803663308367 0.440285352382281 no 1892 0.445988247496458 632 1810509
SGTC_2723 salbutamol 83.58 µM -0.1366701349776 0.439899051099027 no 1893 0.445645768407145 600 9884233 β2-adrenoceptor agonist
SGTC_451 chloral hydrate 100 µM -0.137194326392958 0.439665377248935 no 1894 0.445438597694582 632 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_435 c-PAF 6.7 µM -0.13889901947782 0.438905605547669 no 1895 0.44476497290041 609 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2955 9076254 12.21 µM -0.13979055167749 0.438508344327758 no 1896 0.444412739331048 601 16459619
SGTC_2078 5212016 200 µM -0.139913390271153 0.438453613058815 no 1897 0.444364210725643 610 1899708
SGTC_503 tyrphostin 8 294 µM -0.140631275891332 0.438133779575405 no 1898 0.444080619590738 649 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_81 0411-0046 9.971 µM -0.141993771000803 0.437526869986821 no 1899 0.443542462927436 616 12925265
SGTC_2294 7971431 200 µM -0.142142491280162 0.437460632921244 no 1900 0.443483727856396 640 5741572
SGTC_1700 st030840 7.9285 µM -0.144403324797624 0.436453919373103 no 1901 0.442590995759481 604 5499307
SGTC_825 1988-2224 89.6 µM -0.144589292281928 0.436371129208621 no 1902 0.442517575954881 613 1180859
SGTC_2624 nerol 100 µM -0.145698418138419 0.435877419651878 no 1903 0.442079735093295 611 637566 A natural product oil.
SGTC_846 0335-0850 148 µM -0.14625377102776 0.43563025072338 no 1904 0.441860529363905 619 6819598
SGTC_1464 k208-0027 110 µM -0.146984200558478 0.435305199355115 no 1905 0.441572245497803 603 X1464
SGTC_2004 4023728 41.89 µM -0.147076118089403 0.435264297858697 no 1906 0.441535969935324 617 360084 YDR527W RBA50
SGTC_2649 anisomycin 9.56 µM -0.147944383832406 0.434877970882955 no 1907 0.441193330178931 640 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3225 9130819 49.47 µM -0.148443229183323 0.434656042257069 no 1908 0.440996492999977 641 4547121
SGTC_3003 9075612 71.4286 µM -0.148999914517027 0.434408405822008 no 1909 0.440776850208648 645 6501993
SGTC_3345 9148410 3.559 µM -0.149545192939187 0.434165868596115 no 1910 0.440561725728591 621 4903596
SGTC_457 grayanotoxin iii 135 µM -0.150090835389163 0.433923194256974 no 1911 0.440346475190382 622 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.150496122073529 0.433742959221385 no 1912 0.440186605016191 601 688664
SGTC_2717 st081029 62.2815 µM -0.150920111088868 0.433554421816975 no 1913 0.440019367920713 641 5292846
SGTC_3316 9136639 10.545 µM -0.15166654082571 0.433222539779664 no 1914 0.439724974188094 630 4903665
SGTC_1274 0865-0114 173 µM -0.152012914450208 0.433068549055718 no 1915 0.439588374885385 611 870624
SGTC_1113 artemisinin 1.17947 µM -0.152319452299593 0.432932276989223 no 1916 0.439467491608513 636 2240 An anti-malaria and mitochondrial poison.
SGTC_1971 st069429 63.5 µM -0.152437224201025 0.432879923354501 no 1917 0.439421049730189 613 1246522 YGL099W LSG1
SGTC_1827 berberine 7.24 µM -0.153859389548043 0.4322478155309 no 1918 0.43886030259531 607 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1587 estradiol valerate 56.1 µM -0.153867990195217 0.432243993339227 no 1919 0.438856911808803 620 13791 A steroid.
SGTC_3139 9095020 49.47 µM -0.153945314104836 0.432209630302602 no 1920 0.438826427226579 598 25236292
SGTC_1859 st055998 20 µM -0.156070504149988 0.431265389457624 no 1921 0.437988723853658 649 676301
SGTC_1071 trifluoperazine 6.31 µM -0.15640241291947 0.431117954755498 no 1922 0.437857917673441 643 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_2313 7726885 200 µM -0.15662299201854 0.431019978277756 no 1923 0.437770990584573 611 726423
SGTC_2541 muurolladie-3-one 83.07 µM -0.15679926356415 0.430941685310759 no 1924 0.437701526631613 644 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2928 9011484 9.79 µM -0.157015739987731 0.430845538613394 no 1925 0.437616221626759 650 2994751
SGTC_1590 st077108 57.8 µM -0.160349356228583 0.429365453988486 no 1926 0.436302940591662 604 5489485
SGTC_1641 st009299 47.1 µM -0.160855361682895 0.429140880027275 no 1927 0.436103660297704 620 4046054
SGTC_2001 4023502 57.655 µM -0.161752589171366 0.428742731400155 no 1928 0.435750344810899 613 108941 YCR052W RSC6
SGTC_901 1112-0062 60.1 µM -0.16186869738601 0.428691213161305 no 1929 0.435704626780186 602 1908457
SGTC_791 1348-1292 225 µM -0.161872303535994 0.428689613100203 no 1930 0.435703206859303 616 5437054
SGTC_3310 9130229 44.1445 µM -0.163985523101971 0.427752172788852 no 1931 0.434871270210675 638 7761258
SGTC_2952 9073731 13.78 µM -0.16468764744285 0.427440795047975 no 1932 0.434594920065867 632 16457353
SGTC_929 2805-0021 398 µM -0.164768924192483 0.427404753391801 no 1933 0.434562932292237 665 3098024
SGTC_3036 9090181 49.47 µM -0.167821755077698 0.42605143636903 no 1934 0.433361753575722 610 25236586
SGTC_2216 7189485 200 µM -0.168849799192404 0.425595900511049 no 1935 0.432957393274465 630 731273
SGTC_1002 4049-0206 172 µM -0.169687702739141 0.425224691113777 no 1936 0.432627872804001 612 4662749
SGTC_1061 3448-9325 110 µM -0.169807419158735 0.425171659554076 no 1937 0.43258079601274 626 723482
SGTC_65 0798-0905 34.986 µM -0.170052611701811 0.425063049248557 no 1938 0.432484380495943 730 3602145
SGTC_694 1315-0438 43.2 µM -0.170229439673342 0.424984725191995 no 1939 0.432414850042966 647 6793154
SGTC_522 1273-0010 11.6 µM -0.171683790622942 0.424340648617225 no 1940 0.431843064900109 609 5705015
SGTC_2425 5628681 7.85 µM -0.171926809153727 0.424233044627217 no 1941 0.431747534871603 616 5714958
SGTC_1944 st076371 56.9 µM -0.171934187277195 0.424229777822565 no 1942 0.431744634610546 614 24208455
SGTC_1550 gossypolone 36.6 µM -0.172276123043709 0.424078384965981 no 1943 0.431610227373721 619 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1028 k015-0029 4.8 µM -0.172524617388684 0.423968370544123 no 1944 0.431512554818675 612 4588309
SGTC_1792 st045773 43.6 µM -0.172953994293001 0.42377828903256 no 1945 0.431343794896937 632 2919270
SGTC_987 1497-1013 404 µM -0.172985417411032 0.42376437898074 no 1946 0.431331445020323 622 1676435
SGTC_1185 1319-0113 81.3 µM -0.173785392794542 0.42341028642157 no 1947 0.431017062284305 639 4672763
SGTC_230 MPP+ 141.667 µM -0.17442634119872 0.423126628478496 no 1948 0.430765207168544 647 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1522 st012842 45.6 µM -0.175362144326641 0.422712551306573 no 1949 0.430397542037361 627 3491067 YOR116C RPO31
SGTC_2540 epiandrosterone 100 µM -0.176974828016842 0.421999166454097 no 1950 0.429764080899583 628 441302 A steroid.
SGTC_1105 epirubicin 18.1 µM -0.177110078166165 0.421939348954295 no 1951 0.429710962919828 634 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1938 st074717 56.4 µM -0.178217454731545 0.421449653967744 no 1952 0.429276101131472 622 17250979
SGTC_1969 st069479 40.1 µM -0.17971059421199 0.420789562501138 no 1953 0.428689887939664 624 3895485
SGTC_1741 st038134 10.228 µM -0.18052666155444 0.420428887038886 no 1954 0.428369562666245 640 1272587
SGTC_3307 9126885 69.2785 µM -0.181297983567398 0.420088048968318 no 1955 0.428066844341695 642 24824909
SGTC_1998 st075797 76.8 µM -0.181413939771528 0.420036814468932 no 1956 0.428021339030757 644 24208315
SGTC_2472 5377652 49.4 µM -0.181844746514072 0.419846477170094 no 1957 0.427852283635036 662 1610903
SGTC_2269 7935389 174.42 µM -0.182234301747173 0.419674381586578 no 1958 0.427699427386619 605 97605
SGTC_1860 st056228 74.6 µM -0.183374811161423 0.419170622005506 no 1959 0.427251969261733 668 688679
SGTC_202 3594-0513 34.79 µM -0.183667833211126 0.419041216404257 no 1960 0.427137022476216 631 708429
SGTC_1687 st020778 55.3625 µM -0.183757662598059 0.419001547334737 no 1961 0.427101785413383 617 4259299
SGTC_2976 9009005 19.48 µM -0.184016745840184 0.418887139599871 no 1962 0.427000158985286 617 2993148
SGTC_1707 st032323 6.317 µM -0.184457081830028 0.418692708788697 no 1963 0.426827446567292 630 3132057 YMR211W DML1
SGTC_3287 9117173 37.0625 µM -0.184480493454861 0.418682371917189 no 1964 0.426818264248295 624 2789709
SGTC_853 0419-0306 21 µM -0.184650029886445 0.418607518630173 no 1965 0.426751771217836 634 762713
SGTC_1493 4348-0038 111 µM -0.185218052989503 0.418356748030859 no 1966 0.426529004916414 621 800424
SGTC_2234 tolnaftate 200 µM -0.186304952420192 0.417876996702958 no 1967 0.426102811993646 629 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2099 5377090 177.372 µM -0.186481303519294 0.417799167816442 no 1968 0.426033669662127 646 2243829
SGTC_2986 9022445 71.43 µM -0.186655259104398 0.417722399294285 no 1969 0.425965468772279 645 6459286
SGTC_831 k061-1017 217 µM -0.187191038873829 0.417485973473472 no 1970 0.425755425299579 651 1240153
SGTC_393 acivicin 6.25 µM -0.187252674122368 0.417458777336211 no 1971 0.425731263584032 649 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2526 patulin 37.61 µM -0.187543736862222 0.417330353204491 no 1972 0.425617167462497 636 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1935 st074532 41.6 µM -0.188050911858878 0.417106596039993 no 1973 0.42541837057373 641 2829742
SGTC_191 3914-0123 66.505 µM -0.188769891261792 0.416789440318178 no 1974 0.425136585419322 659 3144412
SGTC_1072 oxiconazole 14.9 nM -0.189013669088408 0.41668191748624 no 1975 0.425041051756474 623 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_913 3487-1245 167 µM -0.189933131427019 0.416276427345736 no 1976 0.424680764937797 619 4016153
SGTC_3191 9110352 49.47 µM -0.19030803655351 0.416111116774039 no 1977 0.424533878237861 617 17122424
SGTC_431 k089-0097 107 µM -0.192531033247221 0.415131215004401 no 1978 0.423663130792053 660 5499420
SGTC_1631 benzylvanillin 81.9 µM -0.192850889799716 0.414990264826227 no 1979 0.423537873597332 640 75506
SGTC_1107 amlodipine 47 µM -0.192979784133108 0.414933468458899 no 1980 0.423487400208165 647 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_894 0960-0238 55.9 µM -0.193003913826208 0.414922836079533 no 1981 0.423477951465315 651 6741907 YDL195W SEC31
SGTC_391 gliotoxin 8.33 µM -0.193394290758168 0.414750831133621 no 1982 0.42332509317598 647 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1012 4112-3522 18 µM -0.194090913017101 0.414443931299847 no 1983 0.423052348348409 648 3112398
SGTC_1939 st074455 53.6 µM -0.194882498237033 0.414095258535637 no 1984 0.422742467939677 638 1644229
SGTC_1114 scopoletin 1.73284 µM -0.195293129836377 0.413914412614298 no 1985 0.422581737561248 639 5280460 A coumarin with genotoxic properties.
SGTC_389 tpck 16.7 µM -0.196004147742021 0.413601316999797 no 1986 0.422303459769729 642 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2692 st077426 47.7 µM -0.197437584061852 0.412970272749137 no 1987 0.421742560297022 653 25238571
SGTC_3111 9122088 49.47 µM -0.197443795485436 0.412967538770991 no 1988 0.421740130129573 661 16876704
SGTC_1991 st073000 8.92 µM -0.197464682974799 0.412958345106071 no 1989 0.42173195809618 649 4301969 YIL048W NEO1
SGTC_1993 st073995 70.8 µM -0.198057220019951 0.412697558795546 no 1990 0.421500147614091 629 3098394
SGTC_605 1315-0399 119 µM -0.199724131526678 0.411964127795623 no 1991 0.420848169886542 637 24020461
SGTC_2445 5742597 35.57 µM -0.200651408340573 0.411556264498744 no 1992 0.420485578699039 632 1774255
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.200661125609942 0.411551990856781 no 1993 0.420481779331378 628 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_536 3852-0578 10.6 µM -0.20089171920279 0.411450579185827 no 1994 0.4203916214202 644 2869208
SGTC_746 1095-0025 46.6 µM -0.201148929947751 0.411337468662507 no 1995 0.420291061613014 639 6749286
SGTC_1286 0929-0070 131 µM -0.201627436712651 0.411127061023396 no 1996 0.420103997163747 640 1420408
SGTC_1696 st025591 34.7925 µM -0.202337370606691 0.410814938018631 no 1997 0.41982649329912 636 2787147
SGTC_2182 6325192 200 µM -0.203566398952562 0.410274728311828 no 1998 0.419346176518353 611 736248
SGTC_1024 4507-0395 26 µM -0.204457501819075 0.409883157464983 no 1999 0.418997999554071 627 4201836
SGTC_957 1187-1561 14.1 µM -0.204665468959013 0.409791784896291 no 2000 0.418916750526679 651 1538454
SGTC_617 3770-0098 35 µM -0.205021781718429 0.409635246495406 no 2001 0.418777553569383 646 5962639
SGTC_3227 9130768 49.47 µM -0.205098979368253 0.409601333254304 no 2002 0.418747396915224 631 17720899
SGTC_737 1950-0117 57.9 µM -0.205408096780714 0.409465543498603 no 2003 0.418626647417141 641 5393513
SGTC_2634 4'-methoxyflavone 100 µM -0.205712329051204 0.409331910302866 no 2004 0.418507813671612 649 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_884 0851-0618 334 µM -0.206086665450649 0.409167498517136 no 2005 0.418361607316262 676 9642473
SGTC_1720 st037298 9.481 µM -0.20675820732898 0.408872591572983 no 2006 0.418099348276408 688 597396
SGTC_2830 7992007 71.43 µM -0.207043132000356 0.408747482764283 no 2007 0.417988086880117 608 1952075
SGTC_3081 9117243 49.47 µM -0.207099924097091 0.408722546787337 no 2008 0.417965910686989 666 45595589
SGTC_1208 2323-2347 50.3 µM -0.207461613160737 0.40856374691793 no 2009 0.417824684367607 665 5412760
SGTC_2553 4-methylesculetin 85.09 µM -0.208229507561936 0.408226652072395 no 2010 0.417524884908927 647 5319502
SGTC_1864 st057645 30.4 µM -0.208243795633198 0.408220380452753 no 2011 0.417519307048723 629 688666
SGTC_62 0180-0423 3.232 µM -0.208597391779758 0.408065180116989 no 2012 0.417381273422627 655 30102 YGL099W LSG1
SGTC_1332 1480-0653 17.5 µM -0.209003155287486 0.407887100268356 no 2013 0.417222887725446 649 5749438
SGTC_2684 capsaicin 100 µM -0.209034384434807 0.407873395334497 no 2014 0.417210698298754 654 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2981 9013952 38.96 µM -0.209368132192974 0.407726936932735 no 2015 0.417080434140972 636 2996344
SGTC_1768 st044301 37.178 µM -0.209400499927777 0.407712733697576 no 2016 0.41706780126452 651 3931349
SGTC_271 rotenone 740 µM -0.209555022709302 0.407644929469239 no 2017 0.417007493398802 661 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1751 st044839 27.194 µM -0.210543323449192 0.407211330972472 no 2018 0.41662182106054 616 5291326
SGTC_351 caspofungin 25 nM -0.211803500248486 0.406658616885542 no 2019 0.416130168836105 627 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2262 9014885 67.46 µM -0.212969326104855 0.406147450667557 no 2020 0.415675444026051 643 6457424
SGTC_3152 9099253 49.47 µM -0.215006317967774 0.405254698677809 no 2021 0.414881196364111 642 25236131
SGTC_2382 9035899 200 µM -0.215456790274332 0.405057336647751 no 2022 0.414705598634768 672 6462679
SGTC_2069 5228469 200 µM -0.216563142163582 0.404572721614509 no 2023 0.414274406162944 672 2835210
SGTC_2371 9071574 200 µM -0.216630210386795 0.404543348435592 no 2024 0.414248270134443 674 45596039
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.216763066347463 0.404485164467423 no 2025 0.414196498195233 632 6708784 An antioxidant flavonoid
SGTC_501 nsc-95397 161 µM -0.217323193683846 0.404239881204462 no 2026 0.413978241528956 662 262093
SGTC_3208 9114115 49.47 µM -0.218834860607757 0.4035781009245 no 2027 0.413389345062833 682 650895
SGTC_2751 anetholtrithion 17.25 µM -0.219324057778192 0.403363998315836 no 2028 0.413198811345589 667 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1794 st048918 76.9 µM -0.220016504139439 0.403060990951726 no 2029 0.412929150589519 635 672303
SGTC_223 busulfan 5 mM -0.220800161817717 0.402718140672699 no 2030 0.412624018789043 652 2478 A DNA alkylator.
SGTC_486 niguldipine 82 µM -0.221257927265723 0.402517902853107 no 2031 0.412445803649443 624 1236 A calcium channel blocker.
SGTC_1435 4092-0789 56.7 µM -0.221465795971032 0.402426984429318 no 2032 0.41236488311765 641 2248285
SGTC_2449 5812982 45.77 µM -0.222314824445306 0.402055687900653 no 2033 0.412034406301935 630 776185
SGTC_2176 5809774 33.9695 µM -0.2237350509447 0.401434793159584 no 2034 0.411481735256484 656 2870539
SGTC_57 miconazole 162.5 nM -0.224043830106186 0.401299833930078 no 2035 0.411361599241888 654 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3303 9125618 40.5795 µM -0.224397001586799 0.401145486424603 no 2036 0.411224201796903 660 22695467
SGTC_2742 clothiapine 36.27 µM -0.224484686642663 0.401107167572577 no 2037 0.411190090585702 645 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_700 3453-2283 142 µM -0.227811352254144 0.399654102250806 no 2038 0.409896450456185 638 565664
SGTC_747 3448-8087 38.7 µM -0.228396317969152 0.399398736126813 no 2039 0.409669075825593 682 5168703
SGTC_2147 5545932 89.7195 µM -0.228465881918904 0.399368370924064 no 2040 0.409642038521305 681 797404
SGTC_1160 4092-0570 10.5 µM -0.228585841364239 0.399316009127426 no 2041 0.409595415093303 633 4994975
SGTC_938 3126-1755 342 µM -0.22951287591747 0.398911423569452 no 2042 0.409235157083861 646 1777771
SGTC_675 1309-0189 238 µM -0.230271330873798 0.398580491922659 no 2043 0.408940468348089 638 4246530
SGTC_1460 k062-0059 9.15 µM -0.231990312776595 0.397830730126565 no 2044 0.408272768929945 623 1373085
SGTC_3346 9158254 43.5805 µM -0.233988432987298 0.396959691814912 no 2045 0.407496979284134 652 17639500
SGTC_3106 9121286 49.47 µM -0.235596026190076 0.39625926824589 no 2046 0.406873078657251 639 15943471
SGTC_1670 st016595 4.04 µM -0.23580249979127 0.396169332521966 no 2047 0.406792964149448 650 597879
SGTC_2364 9055074 200 µM -0.235945566593438 0.396107018757668 no 2048 0.406737454611804 673 6470630
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.23665027605233 0.395800116305217 no 2049 0.406464056587937 667 5282362
SGTC_2061 5245884 80.95 µM -0.237612010528805 0.395381383170361 no 2050 0.406091017114315 662 573863
SGTC_2368 9071271 200 µM -0.240006824897629 0.394339221777929 no 2051 0.405162482860653 676 27209959
SGTC_3004 9076122 71.4286 µM -0.240009177078638 0.394338198539866 no 2052 0.405161571117963 679 44782551
SGTC_2664 lyso-paf C-16 73.48 µM -0.240134591671216 0.394283642151435 no 2053 0.405112959176929 649 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2994 9053520 71.4286 µM -0.24086224623519 0.393967147334244 no 2054 0.40483094195583 696 4647384
SGTC_945 3381-0768 11.3 µM -0.241611268546416 0.393641431702071 no 2055 0.40454069485578 677 1126236 YIL048W NEO1
SGTC_3166 9102297 49.47 µM -0.242317001257572 0.393334608814753 no 2056 0.404267270584605 661 25237072
SGTC_416 estradiol valerate 100 µM -0.243020801030768 0.393028692247217 no 2057 0.403994641760279 665 13791 A steroid.
SGTC_2208 7283366 200 µM -0.243748811981598 0.392712321445651 no 2058 0.403712683385061 647 898663
SGTC_171 k064-0041 9.68 µM -0.244553803790671 0.392362579684195 no 2059 0.403400968601913 626 53325
SGTC_2763 lisinopril 49.32 µM -0.245506072163379 0.391948963474809 no 2060 0.403032303556719 693 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2833 9001315 45.46 µM -0.246147918306198 0.391670247495122 no 2061 0.402783865233877 636 2989378
SGTC_256 clotrimazole 625 nM -0.246563274600247 0.391489912338488 no 2062 0.402623114872391 642 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_793 0488-0545 106 µM -0.247044566873368 0.391280978938159 no 2063 0.402436866691146 645 292548
SGTC_2469 5655019 90.81 µM -0.247044633096729 0.391280950192146 no 2064 0.40243684106587 671 2788239
SGTC_2076 5212012 200 µM -0.247069135644189 0.391270314249845 no 2065 0.402427359779455 639 604802
SGTC_2122 5258151 111.688 µM -0.248495919612058 0.390651123509664 no 2066 0.401875363385437 666 2173356
SGTC_2051 5263410 176 µM -0.248634526913891 0.390590985942028 no 2067 0.401821749188615 629 227584
SGTC_1050 3232-1156 69.3 µM -0.249635794882262 0.390156643501594 no 2068 0.40143450723238 659 700529
SGTC_2236 dapsone 200 µM -0.249786432884482 0.390091309730734 no 2069 0.401376256115392 652 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1457 k015-0032 57.3 µM -0.24985546196045 0.390061371909392 no 2070 0.4013495635782 655 4302660
SGTC_1434 4073-0095 163 µM -0.251222412189097 0.389468661880567 no 2071 0.400821078832658 657 24133745
SGTC_2119 5528445 120.635 µM -0.253871277935827 0.388320845606769 no 2072 0.399797502434986 660 791935
SGTC_1810 st050138 53 µM -0.25390356009711 0.388306862973198 no 2073 0.39978503217197 694 3444541
SGTC_2677 mitomycin C 100 µM -0.253913443127985 0.388302582285058 no 2074 0.399781214480408 656 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1220 1838-0075 193 µM -0.25410504269196 0.38821959645954 no 2075 0.399707203852191 656 5529645
SGTC_2285 7945142 200 µM -0.255138485006137 0.387772078810691 no 2076 0.3993080703849 691 2970608
SGTC_2386 9075165 157.42 µM -0.255639277372262 0.387555271295964 no 2077 0.39911469345421 653 16452277
SGTC_1650 st011916 45.8 µM -0.255874540840957 0.387453431028572 no 2078 0.399023856908005 678 242528
SGTC_1204 4049-0315 18.3 µM -0.255965523660611 0.387414048687158 no 2079 0.398988729396441 662 588402
SGTC_1241 0364-0022 50.8 µM -0.256540187998955 0.387165329309642 no 2080 0.398766876440493 667 4563895
SGTC_2641 levomentholum 100 µM -0.258147934153758 0.386469730116369 no 2081 0.398146369396509 645 16666
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.260507597483127 0.385449471199237 no 2082 0.397236127817124 640 6708630 An antioxidant.
SGTC_2556 citropten 84.59 µM -0.260574214317417 0.385420679225505 no 2083 0.397210438428888 641 2775 A potential DNA crosslinker.
SGTC_474 dl-dihydrosphingosine 5 µM -0.262104742274677 0.384759355169906 no 2084 0.396620345377096 657 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_249 wiskostatin 11.211 µM -0.2630294978336 0.384359940910894 no 2085 0.396263921699331 654 2775510 A n-wasp and actin depolymerizer.
SGTC_642 0335-0876 158 µM -0.263722022027893 0.384060910831443 no 2086 0.395997062486171 639 6812350
SGTC_2571 chrysanthemic acid 100 µM -0.26373374836626 0.38405584802379 no 2087 0.395992544245336 722 2743 An insecticide.
SGTC_462 ag-879 158 µM -0.263772086350237 0.384039295864596 no 2088 0.395977772447378 690 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3349 9149703 23.001 µM -0.264168966239768 0.383867958153152 no 2089 0.395824861618918 669 4910494
SGTC_2505 galangin 7.89 µM -0.264401889797389 0.383767412884408 no 2090 0.395735127739761 685 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3211 9128781 49.47 µM -0.265684435216455 0.383213921477805 no 2091 0.395241125794493 692 17194361
SGTC_1431 4049-0260 9.09 µM -0.265925419322614 0.383109949670439 no 2092 0.395148323968464 664 3854841
SGTC_470 aa-861 153 µM -0.266054572033022 0.383054230619453 no 2093 0.395098590325093 653 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1881 5652484 16 µM -0.266081800311994 0.383042484106511 no 2094 0.395088105579205 699 2255129
SGTC_1422 4031-0024 15.5 µM -0.266925558603092 0.382678532902558 no 2095 0.394763238730438 676 782427
SGTC_1480 1070-0044 41.2 µM -0.267050780989115 0.382624527629821 no 2096 0.39471503138668 652 3124987
SGTC_2690 usnic acid 100 µM -0.267205527836843 0.38255779235076 no 2097 0.394655460124376 703 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3254 9136651 49.47 µM -0.268147025269486 0.382151842539852 no 2098 0.394293074915416 678 16454030
SGTC_491 tetrandrine 80.3 µM -0.271459587871346 0.380724581794708 no 2099 0.393018788662082 681 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1708 st033234 31.827 µM -0.273369969377516 0.379902205038277 no 2100 0.392284417432778 657 674664
SGTC_1054 3429-0080 167 µM -0.273604583679095 0.379801246148519 no 2101 0.392194255553316 703 1162877
SGTC_874 0599-0792 117 µM -0.27519556193525 0.379116835132447 no 2102 0.391582998224405 705 765305
SGTC_1048 3161-0300 24.5 µM -0.275268244847342 0.379085577246014 no 2103 0.391555079670667 646 2165101
SGTC_2661 dactinomycin 12.96 µM -0.275517270362261 0.378978487763351 no 2104 0.391459429618651 659 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_71 0417-1750 47.813 µM -0.275730729049358 0.378886700625357 no 2105 0.391377445915838 631 6811472
SGTC_1780 st038448 24.544 µM -0.276089037247108 0.378732643620179 no 2106 0.39123984028676 706 728868 YDL195W SEC31
SGTC_2145 5634607 200 µM -0.276369968002315 0.378611869037276 no 2107 0.391131960414852 690 308662
SGTC_14 0354-0009 295 µM -0.276773496020589 0.378438409567504 no 2108 0.390977016777244 664 1713507
SGTC_1013 4112-3890 241 µM -0.276926875754414 0.37837248458921 no 2109 0.390918127724001 664 705171
SGTC_2027 5150920 200 µM -0.277634145810783 0.37806853482476 no 2110 0.390646608817338 676 786715
SGTC_1797 st048695 56.8 µM -0.277964597251542 0.377926548955346 no 2111 0.390519767740537 695 592262 YIL048W NEO1
SGTC_1591 genipin 88.4 µM -0.279484125339186 0.377273862159828 no 2112 0.389936659494264 663 442424 A DNA cross-linking agent.
SGTC_1728 st035614 33.7865 µM -0.281878306798488 0.376246194897624 no 2113 0.389018412000782 685 15945546
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.28279436314175 0.375853222660828 no 2114 0.388667237798028 682 5379071
SGTC_1562 morin hydrate 59.1 µM -0.283290408701407 0.375640481441146 no 2115 0.388477114511555 690 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_9 0092-0002 10.449 µM -0.284136588249675 0.375277664009665 no 2116 0.388152854294069 675 759368
SGTC_2265 7929201 200 µM -0.285339368340713 0.374762136424317 no 2117 0.387692077175595 709 1265108
SGTC_80 0159-0065 512.242 µM -0.285581102826776 0.374658552771927 no 2118 0.387599489350892 659 1548079
SGTC_2370 9071495 200 µM -0.286163618552994 0.374408980925 no 2119 0.387376403621709 705 21791103
SGTC_999 SEC7.066 22.7 µM -0.286344292821896 0.374331583895502 no 2120 0.387307218447602 658 740511 YDR170C SEC7
SGTC_2493 resveratrol 26.09 µM -0.286968043914989 0.374064421078563 no 2121 0.387068394425387 654 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2383 9036125 200 µM -0.287198561260657 0.373965702019592 no 2122 0.386980143942693 679 79580
SGTC_2325 6158266 200 µM -0.287300471175581 0.373922061730534 no 2123 0.386941130956885 659 3623240
SGTC_804 1595-0054 20.9 µM -0.288613537505739 0.373359919722507 no 2124 0.386438567369603 701 761523 Stimulates phospholipase C.
SGTC_3094 9117742 49.47 µM -0.288991982569406 0.373197952074168 no 2125 0.386293756453532 671 17149698
SGTC_1974 st069448 26.9 µM -0.289636995545154 0.372921949824673 no 2126 0.386046980600219 660 6323587 YNR016C ACC1
SGTC_3234 9132280 49.47 µM -0.289999536917751 0.372766846318371 no 2127 0.385908295936842 668 17612295
SGTC_443 clozapine 122 µM -0.290669663903596 0.372480204953597 no 2128 0.385651987491174 695 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1570 verbenone 133 µM -0.291517949735715 0.37211745888502 no 2129 0.385327608913809 707 29025 A natural terpanoid with antifungal properties.
SGTC_2983 9022671 12.99 µM -0.292862419379168 0.371542766004359 no 2130 0.384813657496019 718 6405161
SGTC_3311 9131146 2.8755 µM -0.293612918690277 0.371222089833849 no 2131 0.384526851500542 674 4900406 YPR165W RHO1
SGTC_643 k048-0106 28.4 µM -0.293751073902556 0.371163068089857 no 2132 0.384474061874846 674 6763920
SGTC_1807 st050092 58.9 µM -0.294747201958761 0.370737598703436 no 2133 0.38409350106839 702 5008496
SGTC_1667 st014849 34.6 µM -0.296105355394429 0.370157754560497 no 2134 0.383574812137092 658 5348460
SGTC_2465 5809242 33.21 µM -0.296112373477626 0.370154759055408 no 2135 0.383572132419618 693 2731748
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.296392696421231 0.370035116188246 no 2136 0.383465101154393 666 6708739 YPR165W RHO1
SGTC_2804 7954240 19.48 µM -0.296826246557096 0.369850100159605 no 2137 0.383299583094255 670 828705
SGTC_3038 9091290 49.47 µM -0.297237348372646 0.369674691696077 no 2138 0.383142654886356 706 25236843
SGTC_2884 9058502 51.95 µM -0.29767166765033 0.369489406289376 no 2139 0.382976884802058 697 6471554
SGTC_1559 coumarin 343 70.1 µM -0.297874161087735 0.369403030705846 no 2140 0.382899604848487 693 108770 A hepatotoxic, DNA x-linker.
SGTC_1773 st048542 73.5835 µM -0.298077206577292 0.369316426257597 no 2141 0.382822118889035 677 3237138
SGTC_411 enrofloxacin 100 µM -0.299948904995027 0.368518408597057 no 2142 0.382108064972721 693 71188 A bacterial gyrase inhibitor.
SGTC_900 1112-0045 141 µM -0.300491661979629 0.368287104485741 no 2143 0.381901077758583 676 56211 YIL048W NEO1
SGTC_2700 st077718 96.8 µM -0.300540807086839 0.368266162909187 no 2144 0.381882337318566 663 904970
SGTC_2300 7976697 71.57 µM -0.30084828308857 0.368135150976215 no 2145 0.381765094178404 661 2236109
SGTC_1897 st060201 15 µM -0.300965503294531 0.368085208852117 no 2146 0.38172040000004 676 611878
SGTC_2326 6164455 177.58 µM -0.301164111866195 0.368000595987783 no 2147 0.381644677346697 681 2888790
SGTC_36 0335-0881 14.2 µM -0.301525447885761 0.367846673058227 no 2148 0.381506923902468 683 23828853
SGTC_1190 1486-1332 13 µM -0.302642614898006 0.367370913447269 no 2149 0.381081117263116 697 4150046
SGTC_3286 9117135 37.221 µM -0.302855365613612 0.367280333929135 no 2150 0.381000043927699 662 3438150
SGTC_2229 7354935 190 µM -0.302884671718485 0.36726785730949 no 2151 0.380988876601686 704 318112
SGTC_2411 st077133 39.94 µM -0.304726519603507 0.366484000822449 no 2152 0.380287224955402 731 1403142 YNL221C POP1
SGTC_2355 9061122 103.12 µM -0.304964400358682 0.366382803680193 no 2153 0.380196632982767 706 5302957
SGTC_2773 thioridazine 9.09 µM -0.306061349479117 0.365916269514065 no 2154 0.379778967662949 675 5452 An antipsychotic.
SGTC_1142 3253-1408 9.78 µM -0.306698161266102 0.365645523352873 no 2155 0.379536564738592 690 256655
SGTC_836 0330-0104 1.35 µM -0.307212155675506 0.365427042881468 no 2156 0.379340946869066 669 46494820
SGTC_3124 9127567 49.47 µM -0.307851743219238 0.365155238272734 no 2157 0.37909757344044 704 17592030
SGTC_3047 9092122 49.47 µM -0.308063556629351 0.365065239151354 no 2158 0.379016985561393 718 17173831
SGTC_2090 5301565 104.445 µM -0.308408285618698 0.364918780342829 no 2159 0.37888583901916 685 2056344
SGTC_1037 k284-1091 78.7 µM -0.310343637872793 0.364096908456728 no 2160 0.378149824964045 676 3334711
SGTC_627 1391-0720 175 µM -0.311001515955935 0.363817674250025 no 2161 0.377899734588264 693 997839
SGTC_3119 9125183 49.47 µM -0.311947638583023 0.363416222387845 no 2162 0.377540158640395 685 22695334
SGTC_96 0929-0093 37.281 µM -0.31195717587588 0.363412176355923 no 2163 0.377536534511365 678 6991579
SGTC_1342 1486-1464 234 µM -0.312309510775473 0.363262715037338 no 2164 0.377402656370093 685 3253938
SGTC_188 3229-0966 278.469 µM -0.312648311576732 0.363119014548319 no 2165 0.377273934728569 688 5722370
SGTC_2961 9083290 32.55 µM -0.312866994854593 0.363026271473754 no 2166 0.377190856950565 698 17741490
SGTC_1899 st063254 59.6 µM -0.312957442974368 0.362987914982145 no 2167 0.377156497370951 694 3093813
SGTC_1645 Cervolide 78 µM -0.313089202733815 0.362932041850952 no 2168 0.377106445998549 677 23173 A fragrance.
SGTC_1239 0337-0584 35.4 µM -0.313094423767221 0.362929827915769 no 2169 0.377104462735331 704 914301 YML130C ERO1
SGTC_2854 9024559 71.43 µM -0.313316651532424 0.362835598354311 no 2170 0.377020050240317 716 3163529
SGTC_245 methotrexate 289.6 µM -0.314351190885519 0.362397039848781 no 2171 0.376627161252312 685 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2274 7947094 46.08 µM -0.315818270323408 0.361775429994716 no 2172 0.376070224814122 671 2971028
SGTC_1186 1319-0216 26 µM -0.31645312130541 0.361506552948237 no 2173 0.375829300975812 667 4565136
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.316977378416278 0.361284567022789 no 2174 0.375630383625115 698 4620898
SGTC_105 0111-0055 734.78 µM -0.319404888742417 0.3602572973206 no 2175 0.374709752075643 713 5179370
SGTC_2518 prenyletin 46.28 µM -0.319481548296665 0.360224873042672 no 2176 0.374680690591547 674 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.320096422620578 0.359964839358837 no 2177 0.374447618723955 735 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1266 0828-0227 32.9 µM -0.321743923914806 0.359268421807918 no 2178 0.373823349615788 692 3913820
SGTC_1697 st025554 27.742 µM -0.323120464407522 0.358686900681 no 2179 0.373302006249296 667 1269519
SGTC_427 1354-0053 47.3 µM -0.324252434731489 0.358208943777577 no 2180 0.372873463712138 717 6813657
SGTC_1271 0832-2808 169 µM -0.324892360809731 0.357938843141417 no 2181 0.372631269363409 700 3663794
SGTC_1047 2043-3044 82 µM -0.328022148966053 0.356618845558372 no 2182 0.371447457939908 750 669592
SGTC_1398 3558-0053 112 µM -0.328279857523826 0.356510232425383 no 2183 0.371350036213526 670 4532369
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.329569670502967 0.355966806442727 no 2184 0.370862571373788 691 2374 Ca(2+)-ATPase inhibitor.
SGTC_1131 3454-3128 32.3 µM -0.33025480102265 0.355678265076634 no 2185 0.370603721108684 654 710982
SGTC_1620 st003704 16.5 µM -0.330734408483046 0.355476328524473 no 2186 0.370422554681707 661 2834414
SGTC_255 tunicamycin 200.472 nM -0.332155144607471 0.354878372254693 no 2187 0.369886056063908 711 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_865 0488-0499 301 µM -0.332874474225404 0.354575758556298 no 2188 0.36961451915068 712 9634651
SGTC_2958 9077254 16.72 µM -0.334577157884461 0.3538598250911 no 2189 0.36897203907376 691 16457351
SGTC_1509 1326-1131 80 µM -0.335287803475374 0.353561170017656 no 2190 0.368703996612722 663 768313
SGTC_1558 st069300 45.6 µM -0.335305796500242 0.353553609459434 no 2191 0.368697210802701 710 24208000
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.335497299995147 0.353473144450779 no 2192 0.368624990556509 685 17037758
SGTC_2894 9048625 32.47 µM -0.336276175728472 0.353145947734043 no 2193 0.368331306953847 698 4092861
SGTC_711 k292-0785 179 µM -0.336432937545725 0.353080107014946 no 2194 0.368272207490861 698 4146315
SGTC_3091 9116372 49.47 µM -0.336458890538309 0.353069207057232 no 2195 0.368262423470647 702 17169793
SGTC_707 0865-0008 204 µM -0.336742648961317 0.352950039657369 no 2196 0.368155454940793 693 723043
SGTC_1414 3917-0015 5.4 µM -0.338149408922499 0.352359468882083 no 2197 0.367625299142824 711 6618702
SGTC_1 0258-0098 57.368 µM -0.339331951630612 0.351863301738568 no 2198 0.367179837551921 666 6790032 YDR047W HEM12
SGTC_2439 5492030 7.2 µM -0.339424870565824 0.351824325810666 no 2199 0.367144842731514 700 5722370
SGTC_357 1325-0123 420 µM -0.339622355883449 0.351741493469774 no 2200 0.367070470133791 726 1098503
SGTC_3318 9139014 38.6185 µM -0.340921890158489 0.351196598422655 no 2201 0.366581192505679 718 16643984
SGTC_524 r073-0010 27.8 µM -0.341002374497246 0.351162861362791 no 2202 0.366550897087235 719 2772106
SGTC_3116 9124943 49.47 µM -0.341217005550753 0.351072899027156 no 2203 0.366470111055288 664 41905195 YPL160W CDC60
SGTC_1470 k295-0292 231 µM -0.34407679136804 0.349875021622074 no 2204 0.36539426815192 682 5045612
SGTC_2603 homopterocarpin 100 µM -0.345035561874338 0.349473755287435 no 2205 0.365033817991953 695 101795 A weak amylase inhibitor.
SGTC_3163 9099914 49.47 µM -0.345370751063 0.349333510959094 no 2206 0.364907831591559 690 16268368
SGTC_3051 9093778 49.47 µM -0.345800210685214 0.349153853612096 no 2207 0.364746433404433 708 17217378
SGTC_1498 4478-3555 97.6 µM -0.34626842475558 0.348958022494792 no 2208 0.364570497950126 696 3437919
SGTC_2852 9023854 51.95 µM -0.346300058264712 0.348944793190258 no 2209 0.364558612415856 735 19798528
SGTC_1156 4092-0367 4.88 µM -0.347531831387214 0.34842980192642 no 2210 0.364095904479462 693 1357585
SGTC_3262 9137218 49.47 µM -0.347778875656191 0.348326548932408 no 2211 0.36400312765341 692 17650664
SGTC_2266 7929956 200 µM -0.348650456050186 0.347962358756828 no 2212 0.363675871626724 701 2967153
SGTC_820 1582-0060 59.9 µM -0.348940683553383 0.347841118191653 no 2213 0.363566920718429 697 3848840
SGTC_2100 5377183 190 µM -0.349527440186289 0.347596052127899 no 2214 0.363346686991319 688 2844202
SGTC_1693 xanthone 101.9 µM -0.350200886396515 0.34731485759117 no 2215 0.363093970793723 717 7020 An insecticide.
SGTC_1098 clofazimine 15.1 µM -0.351238695441156 0.34688168948561 no 2216 0.362704641178915 685 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1556 plumbagin 1.48 µM -0.352599285531557 0.346314099839006 no 2217 0.362194436648216 703 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1512 0259-0544 12.2 µM -0.353699903178437 0.345855213741191 no 2218 0.361781897583765 676 18476
SGTC_189 3970-0742 2.116 µM -0.353711104253161 0.345850544782607 no 2219 0.361777699964989 720 2891807
SGTC_1471 k673-0312 37 µM -0.354527168654123 0.345510446699985 no 2220 0.361471923436615 695 24099884
SGTC_649 1123-0311 367 µM -0.357332616763871 0.344342217518215 no 2221 0.360421407495185 725 693629 YIL048W NEO1
SGTC_2210 7115885 190.385 µM -0.357634283542524 0.344216687251807 no 2222 0.36030850921012 715 2927039
SGTC_1951 sophoraflavanone G 9.2 µM -0.358887216649872 0.343695497679478 no 2223 0.359839731544878 706 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2954 9074818 52.69 µM -0.359639786881685 0.343382589523838 no 2224 0.359558263017523 741 16648742
SGTC_502 l-744,832 89.3 µM -0.35996290427407 0.343248274758438 no 2225 0.359437437359962 726 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2212 7123476 200 µM -0.360121915278594 0.343182183678388 no 2226 0.359377982366844 689 1085715
SGTC_208 k072-0098 12.366 µM -0.36017054087005 0.343161973972727 no 2227 0.359359801699796 727 5948901
SGTC_2192 5915882 198.485 µM -0.361154796893791 0.342752995257584 no 2228 0.358991865813394 705 2876149
SGTC_1170 0310-0127 64.8 µM -0.361412127475758 0.342646099443302 no 2229 0.358895691706356 726 774975
SGTC_1022 4477-0945 21.3 µM -0.361688932097349 0.342531128126542 no 2230 0.35879224940408 696 4648966
SGTC_970 1315-0089 19.5 µM -0.362078126505652 0.342369500178903 no 2231 0.358646824388058 682 6811083 YLR033W RSC58
SGTC_2730 imipramine 71.33 µM -0.362118197295317 0.342352860880742 no 2232 0.358631852840672 708 3696 A tricyclic antidepressant.
SGTC_720 r052-1644 49.9 µM -0.362204272379522 0.342317119445621 no 2233 0.358599693560092 721 1422863 YOR257W CDC31
SGTC_628 1636-0253 16 µM -0.364326898349386 0.341436177216699 no 2234 0.357806958056307 726 4456143
SGTC_1132 3456-3614 2.5 µM -0.364817619768979 0.341232638376406 no 2235 0.357623775801471 724 3125502
SGTC_3012 9080433 71.4286 µM -0.364836535793849 0.341224793411499 no 2236 0.357616715261668 718 17688859
SGTC_2875 9039966 71.43 µM -0.366574321321916 0.340504381912362 no 2237 0.356968282688908 715 6463691
SGTC_2463 5473429 200 µM -0.366717677737982 0.340444978409213 no 2238 0.356914809479437 708 5399405
SGTC_1953 st076800 12.1 µM -0.367643292166319 0.340061521061666 no 2239 0.35656961483473 691 297591
SGTC_1207 2099-0101 141 µM -0.368329996817767 0.339777144490759 no 2240 0.356313594044306 736 5837381
SGTC_3259 9138485 49.47 µM -0.369038575578224 0.339483805029335 no 2241 0.356049485910957 695 17646153
SGTC_2893 9048488 25.97 µM -0.370319187632383 0.338953900320222 no 2242 0.355572339406962 694 6467338
SGTC_3060 1327-0027 12.5 µM -0.371616722566472 0.338417317899855 no 2243 0.35508911829711 711 16000455 YPR107C YTH1
SGTC_377 3970-0964 33.1 µM -0.371932190465821 0.338286908862455 no 2244 0.354971668583648 696 16481235
SGTC_1719 st032227 49.2 µM -0.372314693550624 0.338128814642651 no 2245 0.354829279939226 686 3125804
SGTC_1733 st037357 54.9 µM -0.373302430704928 0.337720700232411 no 2246 0.354461683779334 740 1272339 YGL099W LSG1
SGTC_2376 9072922 81.32 µM -0.373603433342855 0.337596369502796 no 2247 0.354349689594825 727 17087968
SGTC_118 0083-0097 135.343 µM -0.373868793949889 0.33748677560207 no 2248 0.354250967201328 708 5207356
SGTC_1612 st002233 45.4 µM -0.374177241018651 0.337359404319876 no 2249 0.354136227613485 690 1035021
SGTC_1972 st070201 17.4 µM -0.376658659928422 0.33633539703107 no 2250 0.353213644244965 704 2829099
SGTC_1298 1079-1278 263 µM -0.378192710786598 0.335702946346491 no 2251 0.352643720002486 739 2840950
SGTC_2617 dihydrotanshinone i 20.83 µM -0.378412716676335 0.335612281530375 no 2252 0.352562011398278 680 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2134 5324836 1.464 µM -0.379967830672509 0.334971689454622 no 2253 0.351984647419508 713 699272
SGTC_2865 9030313 51.95 µM -0.380058919877752 0.334934182289378 no 2254 0.35195083947946 701 42562754
SGTC_1994 st072947 40.9 µM -0.380772917449535 0.334640241554334 no 2255 0.35168587841874 745 5286565 YDL195W SEC31
SGTC_1718 roemerine 11.9335 µM -0.381133277269186 0.334491925964657 no 2256 0.351552177967076 714 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2953 9074162 66.49 µM -0.382879764912191 0.333773479164857 no 2257 0.350904457739145 695 16451992
SGTC_842 0271-0008 11.1 µM -0.382927842981793 0.333753710051036 no 2258 0.350886633131673 719 1221709
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.383661012217467 0.333452297040147 no 2259 0.350614856453026 712 390807
SGTC_951 1171-0579 82.7 µM -0.3836893969105 0.333440629976643 no 2260 0.350604336137944 715 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1416 3966-0321 25.3 µM -0.384665558792645 0.333039492725437 no 2261 0.350242607720857 719 582530 YLR208W SEC13
SGTC_1133 3473-0247 50 µM -0.385073613977799 0.33287186590517 no 2262 0.350091438241901 725 711311
SGTC_2567 aureobasidin a 60 nM -0.385385130089836 0.332743919281586 no 2263 0.34997604893487 688 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1489 4065-0444 182 µM -0.386475731436377 0.332296138488902 no 2264 0.349572186305797 712 2877968
SGTC_2913 7966556 36.57 µM -0.387340035619692 0.331941441055894 no 2265 0.349252245065126 734 2976516
SGTC_3098 9119039 49.47 µM -0.388181818741675 0.331596130640666 no 2266 0.348940743432432 685 17161528
SGTC_2919 7978188 46.38 µM -0.388916932649353 0.331294694334486 no 2267 0.348668797953082 666 2980291
SGTC_2795 7780010 54.55 µM -0.388947623155398 0.331282111948555 no 2268 0.348657446103768 699 953673
SGTC_2087 5276107 200 µM -0.389166955906688 0.331192196222414 no 2269 0.348576322929728 708 144405
SGTC_2861 9024595 19.48 µM -0.389996135115958 0.330852361185526 no 2270 0.348269702419721 690 16482810
SGTC_20 0481-0013 4.944 µM -0.390503958922743 0.330644300869355 no 2271 0.348081964216091 716 182045
SGTC_1136 pergolide 1.05886 µM -0.390592631653637 0.330607976159185 no 2272 0.348049186467376 723 47811 A dopamine receptor agonist.
SGTC_1221 2958-7315 257 µM -0.390823345762303 0.330513471793899 no 2273 0.347963908645614 720 4562705
SGTC_1273 0849-0096 14.1 µM -0.391380170839241 0.330285431432781 no 2274 0.347758123568579 728 5286025
SGTC_1825 st052143 62.6 µM -0.392396608450185 0.329869325381927 no 2275 0.347382595795939 739 674173
SGTC_3335 9143315 29.6265 µM -0.39241729820562 0.329860857658233 no 2276 0.347374953420092 693 4899691
SGTC_70 0141-0289 43.283 µM -0.393801787426084 0.329294424228134 no 2277 0.346863692329784 685 352408
SGTC_2979 9012552 45.46 µM -0.394383030983051 0.329056737790515 no 2278 0.346649135013071 722 17100905
SGTC_2850 9015429 58.44 µM -0.394519546759486 0.329000922760412 no 2279 0.346598749396809 718 6457570
SGTC_1637 st007924 17.4 µM -0.39683246724444 0.328055856148878 no 2280 0.345745503471976 694 683336
SGTC_1866 st057638 64 µM -0.397386570580921 0.327829610840717 no 2281 0.345541208545399 717 688802
SGTC_2691 st077356 60.2 µM -0.398202856526226 0.327496429156107 no 2282 0.345240330251701 729 2839272
SGTC_1759 st043059 70 µM -0.39826329075087 0.327471767305578 no 2283 0.345218058430551 741 669426
SGTC_887 0885-0007 9.62 µM -0.398690039787967 0.327297642035953 no 2284 0.345060803894805 742 5719458
SGTC_1255 0566-0045 221 µM -0.399274928415991 0.327059052534535 no 2285 0.344845319306035 711 2788469
SGTC_1440 4100-1550 40 µM -0.4017681826927 0.326042790491794 no 2286 0.343927320063315 726 742806
SGTC_1834 st055981 52.8 µM -0.40541340584923 0.324559304883793 no 2287 0.342586829250735 736 471719 YDL150W RPC53
SGTC_442 cape 100 µM -0.405707260351626 0.324439836542197 no 2288 0.342478853504833 720 5281787
SGTC_1530 rhein 70.4 µM -0.40619146087676 0.32424302127797 no 2289 0.34230096390255 701 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2041 5107442 45.335 µM -0.407080726502349 0.323881685220239 no 2290 0.341974349275528 725 793005
SGTC_2698 st077697 67.5 µM -0.407381858777845 0.323759363472392 no 2291 0.341863774452588 721 3154499
SGTC_2428 5615643 7.78 µM -0.407460671858233 0.323727352265781 no 2292 0.34183483677697 748 2253075
SGTC_3222 9128301 49.47 µM -0.408833257523839 0.323170063702812 no 2293 0.341331015792135 727 4911358
SGTC_2676 harmalol 100 µM -0.40974625116439 0.322799595354257 no 2294 0.340996049032643 710 5459187 A monoamine oxidase inhibitor
SGTC_111 0083-0039 52.457 µM -0.410181106575027 0.322623204463766 no 2295 0.340836549668167 720 759313
SGTC_568 1193-0097 7.48 µM -0.410647855945654 0.322433920799143 no 2296 0.340665383664027 718 3646150
SGTC_2912 7964298 10.93 µM -0.410882408803365 0.322338818546865 no 2297 0.340579380985933 731 2975850
SGTC_2950 9072895 21.46 µM -0.411156826716435 0.322227567291942 no 2298 0.340478771648007 727 17332245
SGTC_2070 5230947 200 µM -0.411611729747967 0.322043180981935 no 2299 0.340312016388399 756 2835538
SGTC_579 4491-1009 110 µM -0.411653143892552 0.322026396718909 no 2300 0.340296836623044 755 1271041
SGTC_218 alverine citrate 93.75 µM -0.412266469416244 0.321777871573453 no 2301 0.340072061187092 733 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_580 1123-0028 41 µM -0.412455322012284 0.321701362810433 no 2302 0.340002860727297 733 1677248 YPR107C YTH1
SGTC_3056 9094900 49.47 µM -0.413321165937779 0.321350685286517 no 2303 0.339685662228336 727 25236784
SGTC_177 1327-0068 8.361 µM -0.41368738313481 0.321202410668439 no 2304 0.339551534148713 701 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3024 9090631 49.47 µM -0.413716781456122 0.321190509063343 no 2305 0.339540767811574 701 25236383
SGTC_3243 9134147 49.47 µM -0.413807457936202 0.321153800788858 no 2306 0.339507560837092 743 24282180
SGTC_2228 7354201 200 µM -0.414150015190039 0.321015140185163 no 2307 0.339382122904678 726 753451
SGTC_1518 st038567 90.8 µM -0.414279080224389 0.320962903607275 no 2308 0.339334866365483 739 77966
SGTC_544 k015-0020 52.4 µM -0.414399716509426 0.320914081606609 no 2309 0.339290698256706 721 3008304
SGTC_1851 st056236 18.9 µM -0.416624103564113 0.32001441868355 no 2310 0.338476688055479 730 5393171
SGTC_429 1112-0049 25.5 µM -0.416777338910909 0.319952480860273 no 2311 0.338420639595441 700 2836170
SGTC_131 0141-0277 33.849 µM -0.41687045157979 0.3199148471123 no 2312 0.338386583785766 749 1547771
SGTC_2703 st077852 53.4 µM -0.417282240230603 0.31974843494859 no 2313 0.338235988598759 749 6281836
SGTC_1766 st045414 44.774 µM -0.418361929898598 0.319312282732296 no 2314 0.337841258311861 716 253960
SGTC_278 4092-0821 23.9 µM -0.418663666792853 0.319190437534494 no 2315 0.337730976346335 751 877900
SGTC_2747 doxorubicin 7.63 µM -0.41905954460138 0.319030606656959 no 2316 0.33758630790128 705 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1375 2910-0797 186 µM -0.419479663213089 0.318861025641186 no 2317 0.337432807214586 741 742508
SGTC_7 0192-1582 4.227 µM -0.420265236294184 0.318544030564632 no 2318 0.337145851327725 742 252616
SGTC_1257 0669-0121 16 µM -0.42037138413607 0.318501207880044 no 2319 0.337107084668357 723 4307855
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.421225146518301 0.318156867071941 no 2320 0.336795341782 733 688803
SGTC_366 0181-0206 4.31 µM -0.421284142181226 0.318133078646693 no 2321 0.336773804237663 749 274874
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.422337166605501 0.317708600949191 no 2322 0.336389466757374 684 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2923 7992654 58.14 µM -0.422573898091144 0.317613206641341 no 2323 0.33630308697455 698 2985126
SGTC_1949 st076024 69.1 µM -0.423639089789285 0.317184122435864 no 2324 0.335914521403516 734 2921930
SGTC_976 1348-1067 47.6 µM -0.423706734153989 0.317156881988151 no 2325 0.335889851694168 719 5310671 YGL099W LSG1
SGTC_919 tnp00227 403.569 nM -0.42473714495244 0.316742057169517 no 2326 0.335514151248552 742 1269246 A methoxyflavone. YNL221C POP1
SGTC_2869 9037858 32.47 µM -0.424940632675724 0.316660163897373 no 2327 0.335439976550169 704 27187042
SGTC_3279 9140807 49.47 µM -0.426397111982474 0.316074268909993 no 2328 0.334909252732384 724 45595718
SGTC_1845 st056753 3.01 µM -0.426852831614321 0.315891042237142 no 2329 0.334743261527485 701 5375839
SGTC_713 1488-1073 324 µM -0.427162626869703 0.315766511749472 no 2330 0.3346304402134 743 3312542
SGTC_1137 ixabepilone 100 µM -0.428153176315895 0.315368474286479 no 2331 0.334269801891284 710 154225 A novel microtubule stabilizer.
SGTC_1439 4092-1168 46 µM -0.43061098128484 0.314381767933796 no 2332 0.33337562759518 740 2886240
SGTC_645 0845-0943 5.41 µM -0.431079650241618 0.314193767030642 no 2333 0.333205228332666 731 1885106
SGTC_1826 st055655 41.6 µM -0.431910398968726 0.3138606406483 no 2334 0.332903268247512 712 676168
SGTC_1669 st015249 58.4 µM -0.432822817974459 0.313494939624865 no 2335 0.332571747525601 736 722793
SGTC_1606 st000094 49.2 µM -0.433166530929675 0.313357225657877 no 2336 0.332446895886491 738 1242210
SGTC_1209 2323-2347 50.3 µM -0.433665819243569 0.313157224345459 no 2337 0.332265565559275 702 5412760
SGTC_1005 4092-0690 4.4 µM -0.433799836535672 0.313103550017452 no 2338 0.332216900163408 752 1529343
SGTC_702 1488-0190 94 µM -0.43436110336447 0.312878803998599 no 2339 0.332013119354093 738 949357
SGTC_1171 0368-0077 21.4 µM -0.435664423889263 0.312357188427616 no 2340 0.331540110600959 716 3239779
SGTC_3341 9147222 25.867 µM -0.43585603316576 0.312280534131761 no 2341 0.331470593258203 748 1939759
SGTC_2816 7982706 58.44 µM -0.436325505176044 0.312092753736756 no 2342 0.331300289686451 740 2981853
SGTC_1623 st003709 20.3 µM -0.437335901352853 0.311688778991811 no 2343 0.330933881238962 700 16192618
SGTC_1615 st002656 86.5 µM -0.438012047675502 0.311418569884411 no 2344 0.330688775010127 712 1584458
SGTC_3200 9114385 49.47 µM -0.439076527748297 0.310993376355201 no 2345 0.33030304307991 730 17018030 YLR208W SEC13
SGTC_3179 9107801 49.47 µM -0.439167627755166 0.310956999279906 no 2346 0.330270039856143 707 4818259
SGTC_966 1300-0360 30.2 µM -0.439514873538465 0.310818357768581 no 2347 0.330144253619212 745 70588
SGTC_572 0960-0087 17.7 µM -0.439653274993754 0.31076310702331 no 2348 0.330094124455678 732 6796365
SGTC_872 0588-0139 234 µM -0.43972601227734 0.310734071545385 no 2349 0.330067780152065 701 2047100
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.440084651364146 0.31059092620003 no 2350 0.329937899019723 737 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1128 3448-9350 235 µM -0.44020936971021 0.310541153484485 no 2351 0.329892737078026 698 619386
SGTC_2688 kanamycin b 96.69 µM -0.440536707131763 0.310410535855505 no 2352 0.329774216243277 745 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2337 9009472 200 µM -0.441525131645449 0.310016269412398 no 2353 0.32941643577784 753 5742383
SGTC_792 4534-1957 155 µM -0.443113854466334 0.309383011404989 no 2354 0.328841692291608 717 1717904
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.443305974570657 0.309306471470275 no 2355 0.328772217451708 728 6857784
SGTC_1479 0549-0158 134 µM -0.444798157225289 0.308712273349826 no 2356 0.328232813104698 734 5440202
SGTC_2799 7812892 81.82 µM -0.444898910998883 0.308672170475027 no 2357 0.328196404832302 761 20205235
SGTC_1886 st057356 49.9 µM -0.445328610957589 0.308501163260089 no 2358 0.328041147255235 710 24207747
SGTC_2940 9060638 45.86 µM -0.446272796046599 0.308125552903343 no 2359 0.327700102225968 723 4027022
SGTC_2942 9052777 62.25 µM -0.447463161692442 0.307652294654923 no 2360 0.327270340156555 759 6469503
SGTC_2187 6125751 200 µM -0.447480418447538 0.30764543617109 no 2361 0.327264111568741 740 874498
SGTC_3332 9141069 11.198 µM -0.447675305673166 0.307567985321381 no 2362 0.327193773050907 724 17332883
SGTC_497 capsazepine 133 µM -0.449172102819921 0.306973423772206 no 2363 0.326653755116064 721 2733484 A calcium channel blocker.
SGTC_1659 st012954 42.1 µM -0.450614706364763 0.306400869122333 no 2364 0.326133632732333 759 24207262
SGTC_638 3970-0837 4.09 µM -0.451038244651026 0.306232860724098 no 2365 0.32598099259312 723 4118451 YLR208W SEC13
SGTC_587 k089-0003 57 µM -0.451066273158137 0.306221743863631 no 2366 0.325970892349948 733 9659696
SGTC_321 4534-3890 65.3 µM -0.451239348812835 0.306153101352345 no 2367 0.325908526313116 737 699746
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.451343278857902 0.306111885542069 no 2368 0.325871078527816 783 5282309
SGTC_1477 0139-0234 16 µM -0.451619067713895 0.306002527131008 no 2369 0.325771715568871 735 620880
SGTC_2149 5554786 194.827 µM -0.452454148445458 0.305671498473116 no 2370 0.325470922875586 738 745063 YPR165W RHO1
SGTC_183 3914-0051 30.55 µM -0.452521418350672 0.305644839374471 no 2371 0.325446697471636 751 1596232
SGTC_1355 1499-0035 1.68 µM -0.452894334759198 0.305497071094727 no 2372 0.325312415273719 739 1548538
SGTC_965 1291-5240 308 µM -0.454697645557391 0.304782955781111 no 2373 0.324663387477188 763 2834598
SGTC_186 3455-3465 67.277 µM -0.455416222621975 0.304498604464967 no 2374 0.324404913246668 756 755278
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.455769751375519 0.304358751373955 no 2375 0.324277778973195 749 688667
SGTC_3050 9093513 49.47 µM -0.455812341759814 0.304341904895644 no 2376 0.324262464210661 754 25236664
SGTC_1122 capsaicin 818.572 nM -0.456118856401957 0.304220676343269 no 2377 0.324152255639025 761 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2128 5255449 168.493 µM -0.457563133227464 0.303649745087062 no 2378 0.323633167569669 721 736008
SGTC_1878 temozolomide 1 mM -0.460533120213228 0.302477197376581 no 2379 0.32256680204965 760 5394 DNA alkylating agent.
SGTC_771 0250-0039 27.3 µM -0.461105209475421 0.30225157052279 no 2380 0.322361562191137 749 3005115
SGTC_682 0kpi-0099 17 µM -0.461208832208665 0.302210710729704 no 2381 0.32232439281106 751 1714895 YML126C ERG13
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.462275790568919 0.301790139412088 no 2382 0.321941779183799 757 368090
SGTC_1930 st074634 34.3 µM -0.462385587666874 0.301746874765193 no 2383 0.321902416402539 766 684253 YOR116C RPO31
SGTC_1588 farnesol 29.9 µM -0.462644336611497 0.301644927893734 no 2384 0.321809661580913 725 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2066 5222451 176 µM -0.46342974693975 0.301335571787181 no 2385 0.321528180260531 747 2281147
SGTC_1021 4476-0760 85.3 µM -0.464528045697639 0.300903215430567 no 2386 0.321134735413861 730 746768
SGTC_490 phenamil 164 µM -0.466681605903792 0.300056257960861 no 2387 0.320363845908415 742 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2138 5575593 77.673 µM -0.466767558072163 0.300022476870594 no 2388 0.320333094478064 765 762213
SGTC_2378 9074213 121.43 µM -0.46679287910737 0.300012525475659 no 2389 0.320324035511372 736 657714
SGTC_2511 berberine 10.47 µM -0.468187234870551 0.29946476181223 no 2390 0.319825349981779 753 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_199 4063-0024 41.6 µM -0.469530228518062 0.298937604500685 no 2391 0.319345341574237 747 306215
SGTC_609 0986-0026 86.3 µM -0.470123867203087 0.298704721452227 no 2392 0.319133261568757 749 2848610
SGTC_2050 5263056 171 µM -0.470554645252948 0.298535779902878 no 2393 0.318979401284621 741 763468 YGL055W OLE1
SGTC_2706 st078239 82.5 µM -0.470772726737861 0.298450269780479 no 2394 0.318901521369585 760 15434492
SGTC_3291 9121177 71.43 µM -0.471000998557967 0.298360775950484 no 2395 0.31882001090933 750 17015612
SGTC_1912 st060209 90.8 µM -0.472338380752981 0.297836701664796 no 2396 0.318342639579551 783 688787
SGTC_3000 9075062 71.4286 µM -0.472397583480811 0.297813511849244 no 2397 0.318321514449479 755 17057871
SGTC_2180 6301957 200 µM -0.472683585373176 0.297701495990802 no 2398 0.318219469582425 761 845462
SGTC_2504 purpurogallin 52.29 µM -0.472723104387245 0.297686019436143 no 2399 0.318205370366813 717 5281571 An antioxidant.
SGTC_3045 9092950 49.47 µM -0.472991314484853 0.297580991896613 no 2400 0.31810968789597 751 44120432
SGTC_529 4076-0302 30.3 µM -0.474119926937425 0.297139227586279 no 2401 0.317707194696178 742 5816522
SGTC_1032 k061-1018 98.7 µM -0.474738070118817 0.296897399584035 no 2402 0.317486839640945 773 4005393
SGTC_829 1635-0120 117 µM -0.475080915414981 0.296763311580515 no 2403 0.317364650367565 765 285054
SGTC_879 0831-1030 162 µM -0.478333479598062 0.295492603752617 no 2404 0.316206435497395 760 1549252
SGTC_762 1165-0429 115 µM -0.479957593661839 0.294859034940837 no 2405 0.315628773502295 772 5967793
SGTC_2521 angolensin 13.4 µM -0.480151828315649 0.294783305711496 no 2406 0.315559718578383 737 821428 A flavenoid.
SGTC_2218 6965428 192.983 µM -0.480750105519274 0.294550102614048 no 2407 0.315347057633947 743 675684
SGTC_3146 9095609 49.47 µM -0.483108763700752 0.29363154921328 no 2408 0.314509255908497 735 17173999
SGTC_1632 st005650 90 µM -0.484209417187512 0.293203366122757 no 2409 0.314118627115113 736 2759605
SGTC_2482 5981709 142.65 µM -0.484488715597611 0.293094757779224 no 2410 0.314019535459537 763 877755
SGTC_25 0118-0223 35.662 µM -0.484703337910685 0.293011312147409 no 2411 0.313943399200982 767 5333628
SGTC_2363 9053361 176 µM -0.487217129115249 0.292034766172823 no 2412 0.313052233908224 774 6469797 YMR079W SEC14
SGTC_2878 9043973 25.97 µM -0.487667174785004 0.291860094548418 no 2413 0.312892803008055 750 6465167
SGTC_2525 harmine 47.85 µM -0.488170379564306 0.291664848469988 no 2414 0.312714581661924 743 5280953 A monoamine oxidase inhibitor
SGTC_2455 5377712 9.75 µM -0.489073150449863 0.291314721335316 no 2415 0.31239495468405 719 2243908
SGTC_2019 4016004 108 µM -0.489166542137888 0.291278511866459 no 2416 0.312361897308577 755 45595336
SGTC_1279 0874-0590 65.2 µM -0.490534741528036 0.290748279808775 no 2417 0.311877776043771 748 3523074
SGTC_2784 7567673 72.73 µM -0.491223289135435 0.290481610872269 no 2418 0.311634264387693 758 3471247
SGTC_1001 4048-4355 44.4 µM -0.491520889213599 0.29036638820431 no 2419 0.311529040666176 768 21824233
SGTC_1900 st060200 72.8 µM -0.492113334051586 0.290137073381842 no 2420 0.311319613256046 734 688945
SGTC_2256 7954252 200 µM -0.492678044599397 0.289918572570329 no 2421 0.311120046660196 771 2972920
SGTC_1553 gossypol 38.6 µM -0.493262386800528 0.28969255704702 no 2422 0.310913600756336 750 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_933 2914-0560 114 µM -0.494226584995699 0.289319799358669 no 2423 0.310573083263256 740 463887
SGTC_340 k038-0059 454 µM -0.494350335420604 0.289271973940967 no 2424 0.310529391143479 739 23733424
SGTC_250 brefeldin a 552.239 µM -0.495530119850317 0.288816213230572 no 2425 0.310112983154399 752 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2731 amoxapine 43.43 µM -0.497017334585462 0.288242171686299 no 2426 0.309588413649521 777 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3161 9100388 49.47 µM -0.497567815442384 0.288029831258619 no 2427 0.309394346605658 773 25236368
SGTC_58 0957-0393 9 µM -0.497701989810782 0.287978086532895 no 2428 0.309347052700659 763 6997992
SGTC_1775 st081588 35.1725 µM -0.50030068719713 0.286976758195369 no 2429 0.308431685148674 791 1426443 YGL099W LSG1
SGTC_2142 5622915 118.518 µM -0.501007093701526 0.286704851485863 no 2430 0.308183065267291 737 5322196
SGTC_873 0591-4978 488 µM -0.503243451633847 0.285844849417591 no 2431 0.30739655929596 787 3305145
SGTC_744 1594-0068 283 µM -0.503295332850776 0.285824912816352 no 2432 0.307378323650108 759 668392
SGTC_3348 9149464 3.537 µM -0.503907902310435 0.2855895683275 no 2433 0.307163048602867 744 1951442
SGTC_770 0389-1121 67.2 µM -0.50441325594816 0.285395484785528 no 2434 0.306985502382579 738 6753108
SGTC_154 3389-1638 511.116 µM -0.504466391272117 0.28537508155389 no 2435 0.306966836943421 803 5238686
SGTC_3223 9129970 49.47 µM -0.504775011733615 0.285256589290155 no 2436 0.306858434277762 743 17248386
SGTC_406 estrone 100 µM -0.505147239484569 0.285113706729613 no 2437 0.306727712073429 770 5870 A steroid.
SGTC_1702 st027038 51 µM -0.506186907747428 0.284714802678636 no 2438 0.306362722494668 757 5521182
SGTC_2957 9076800 11.52 µM -0.506313375425211 0.28466629723661 no 2439 0.306318337403555 774 16459615
SGTC_1534 6-azauridine 81.6 µM -0.509439697830726 0.283468482767768 no 2440 0.305222028231751 749 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1372 2752-0194 270 µM -0.510052207426491 0.283234090080082 no 2441 0.305007443303488 764 823334
SGTC_2561 acetosyringone 100 µM -0.510212251216173 0.28317286049479 no 2442 0.304951385044804 787 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_607 4491-0986 66.8 µM -0.510920002027379 0.282902165212141 no 2443 0.304703537297195 758 698981 YDR232W HEM1
SGTC_1765 st044815 90.4 µM -0.511883754947143 0.282533756073309 no 2444 0.304366184097435 762 645695
SGTC_2307 7538926 6.34 µM -0.514980008812952 0.281351729610313 no 2445 0.303283494866985 766 96582
SGTC_758 0868-0029 16 µM -0.515593223500377 0.281117912136567 no 2446 0.303069272107522 730 762687
SGTC_559 1550-0661 158 µM -0.516454011531952 0.280789853902501 no 2447 0.302768675394451 756 5830875
SGTC_2746 daunorubicin 9.88 µM -0.517443756269848 0.280412877433033 no 2448 0.302423210706627 754 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_960 1222-0186 7.7 µM -0.518131238968765 0.28015117158467 no 2449 0.302183352925263 772 3126296
SGTC_1232 0279-0259 161 µM -0.519722061071922 0.279546043335823 no 2450 0.301628654180972 764 1560000
SGTC_3178 9107506 49.47 µM -0.52158459830388 0.278838365597853 no 2451 0.300979794583267 761 8897194
SGTC_1638 st008370 60.6 µM -0.52206041999755 0.278657715338623 no 2452 0.300814131636124 760 24207134
SGTC_1736 st036774 51 µM -0.522193167201978 0.278607326761192 no 2453 0.300767921467547 790 1272247
SGTC_1926 methyl fluorone black 53.6 µM -0.52407041561238 0.277895230704168 no 2454 0.30011478225434 751 72721 Reacts with homocysteine.
SGTC_1822 st052468 42 µM -0.525088713721545 0.27750933200765 no 2455 0.299760760781878 759 2873678
SGTC_1806 st050005 60.3 µM -0.526348159470464 0.277032409513246 no 2456 0.299323163734822 757 5194765
SGTC_528 3492-0019 172 µM -0.526470691627034 0.276986030889615 no 2457 0.299280605152991 767 2869262
SGTC_3250 9135583 49.47 µM -0.526539844161782 0.276959858218995 no 2458 0.299256587903972 758 7699353
SGTC_2621 lithochol-11-enic acid 100 µM -0.526936362930299 0.276809808211744 no 2459 0.299118890531691 792 6708711
SGTC_1382 3002-2117 298 µM -0.52881763883331 0.276098441860415 no 2460 0.298465980205576 806 1497314
SGTC_1253 0550-0034 176 µM -0.528891086720401 0.27607068724463 no 2461 0.298440502745729 743 5969915
SGTC_1340 1486-1359 257 µM -0.529945557131417 0.275672373198695 no 2462 0.29807483925236 766 4309068
SGTC_1287 0971-0001 34.6 µM -0.530301832288579 0.275537858245231 no 2463 0.297951338253641 749 4665869
SGTC_2569 tetrandrine 100 µM -0.530464872673265 0.275476311620793 no 2464 0.297894828901751 747 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3127 9126946 49.47 µM -0.530588991710857 0.275429462071461 no 2465 0.297851812858751 780 27243249
SGTC_2593 nobiletin 86.24 µM -0.531037532371831 0.275260190126721 no 2466 0.297696385350427 759 72344 An anti-infammatory.
SGTC_1870 st057514 26.5 µM -0.533417359474307 0.274362939673628 no 2467 0.296872351682204 755 5393161
SGTC_1153 4055-0057 267 µM -0.534151556785729 0.27408642182783 no 2468 0.296618340996456 771 882706
SGTC_2402 5553605 200 µM -0.535337196881019 0.273640169784084 no 2469 0.296208354705179 766 6758546
SGTC_53 0973-0023 39.979 µM -0.535956819295755 0.273407098978147 no 2470 0.295994196957795 794 674768
SGTC_947 3447-0010 211 µM -0.535997309999226 0.273391871832958 no 2471 0.29598020478393 777 748350
SGTC_963 1269-2853 151 µM -0.536751527829636 0.273108313524785 no 2472 0.295719628952776 736 3668223
SGTC_718 1130-0073 349 µM -0.537920377754645 0.272669156895892 no 2473 0.295316009680809 786 6740020
SGTC_798 1287-0182 476 µM -0.538690306447955 0.272380073279628 no 2474 0.295050281732937 793 1649755
SGTC_3215 9129942 49.47 µM -0.539713581051233 0.271996102145997 no 2475 0.294697286261834 793 17682944
SGTC_487 nimodipine 119 µM -0.53974973562027 0.271982540516503 no 2476 0.294684817709427 761 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2829 7992743 58.44 µM -0.54124910243989 0.271420422259929 no 2477 0.294167948549335 772 16462845
SGTC_2335 9018011 154.17 µM -0.541679257076244 0.271259262583076 no 2478 0.2940197408749 750 6458208
SGTC_2638 epoxomicin 18 µM -0.542347221520209 0.271009100802206 no 2479 0.293789665442433 757 9915668 A protesome inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.544126521876797 0.270343290685685 no 2480 0.2931772053823 773 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2475 5812728 15.03 µM -0.545043963168258 0.270000306046387 no 2481 0.29286164075897 767 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1058 3448-5425 97.3 µM -0.545501552174859 0.269829318214932 no 2482 0.292704306640642 792 7279705
SGTC_2366 9070441 60.58 µM -0.545619995848527 0.269785068060225 no 2483 0.292663588215053 774 6837235
SGTC_1059 3448-6867 171 µM -0.545906485563566 0.269678051501058 no 2484 0.292565110001273 785 3934407
SGTC_1853 st056710 91.2 µM -0.54628662025738 0.269536087240649 no 2485 0.292434465959381 779 269167
SGTC_3203 9113543 49.47 µM -0.546733123585025 0.269369384940762 no 2486 0.292281047104595 761 17018012
SGTC_1651 st011928 86.1 µM -0.547938299426794 0.268919690000743 no 2487 0.291867134854148 770 720198
SGTC_959 1222-0044 107 µM -0.54804483298613 0.268879956594864 no 2488 0.291830559518099 773 6083612
SGTC_2054 5233173 129 µM -0.54882066169281 0.268590687723475 no 2489 0.291564264717752 744 6889
SGTC_625 k213-0058 121 µM -0.550069907355701 0.268125233567153 no 2490 0.291135712951196 788 3655420
SGTC_2053 5265679 138 µM -0.550409879207946 0.267998634386684 no 2491 0.291019137079523 785 764595
SGTC_2025 5147754 141 µM -0.551671128563876 0.267529231729759 no 2492 0.290586847077852 768 315777 YLR208W SEC13
SGTC_728 3030-5151 22.5 µM -0.553071122571263 0.267008678001773 no 2493 0.290107354835764 778 3125388
SGTC_3266 9136860 49.47 µM -0.554301657354257 0.266551556342351 no 2494 0.289686208126674 771 4871271 YPR165W RHO1
SGTC_2598 perillyl alcohol 100 µM -0.554333698780401 0.266539658814701 no 2495 0.289675245882124 760 10819 An apoptosis inducer.
SGTC_1120 ficusin 1.78878 µM -0.554685619652578 0.266409002273127 no 2496 0.289554856981934 795 6199 A DNA cross-linker.
SGTC_396 dithiazanine 1.25 µM -0.555041328655542 0.26627697226116 no 2497 0.289433196076054 769 10578 An antihelmenthic.
SGTC_145 3737-0113 38.366 µM -0.555221392606046 0.266210149792552 no 2498 0.289371619094757 774 6849351
SGTC_151 3013-0144 2.285 µM -0.557438626076309 0.265388021842299 no 2499 0.288613890475936 787 906558 YHR107C CDC12
SGTC_3271 9137798 49.47 µM -0.560197100309959 0.264367009037683 no 2500 0.287672502328432 770 6498326
SGTC_140 0062-0056 502.533 µM -0.562878569926668 0.263376418714105 no 2501 0.286758786896656 776 3758964
SGTC_430 0958-0115 16.4 µM -0.563422690328352 0.26317564092671 no 2502 0.286573544968364 769 6833180
SGTC_3230 9131665 49.47 µM -0.563980898389082 0.262969746147589 no 2503 0.286383566001934 775 15943720
SGTC_392 N-ethylmaleimide 8.33 µM -0.565215439858855 0.26251467872443 no 2504 0.285963618050756 766 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2467 5474540 200 µM -0.565348842168433 0.262465529108342 no 2505 0.285918256766873 756 5413519
SGTC_569 4130-2812 160 µM -0.56757090285794 0.261647545247829 no 2506 0.285163184685786 798 743552
SGTC_1490 4089-0339 670 nM -0.567862061409647 0.261540461132795 no 2507 0.285064317397113 781 742542
SGTC_1328 1441-0025 69.2 µM -0.568152712461241 0.261433586113288 no 2508 0.284965638740221 789 4562601
SGTC_1356 1502-0781 85.8 µM -0.568260575080327 0.261393929759484 no 2509 0.284929022552015 780 567702
SGTC_1769 st044406 64.4 µM -0.570488320738436 0.260575576773327 no 2510 0.284173270662706 805 670903
SGTC_2348 9022543 33.42 µM -0.571733140585285 0.260118872546329 no 2511 0.283751389450371 789 3162678 YDL140C RPO21
SGTC_2685 mycophenolic acid 18.85 µM -0.572696654221162 0.259765658523278 no 2512 0.28342505161925 776 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_283 0987-0079 11.7 µM -0.572795781587166 0.259729333514294 no 2513 0.283391487826137 769 411556
SGTC_3159 9100096 49.47 µM -0.572808640881024 0.259724621445964 no 2514 0.283387133903966 778 25236875
SGTC_1808 st050063 61.5 µM -0.573389694787523 0.259511750225145 no 2515 0.283190433129225 817 4011993
SGTC_548 1436-0017 110 µM -0.57376938489635 0.259372698057166 no 2516 0.283061934256024 792 9677137
SGTC_2702 st077768 96.8 µM -0.57507265624903 0.258895699950921 no 2517 0.282621079939598 757 6484119
SGTC_1634 st006576 41 µM -0.576982704647717 0.258197441933141 no 2518 0.281975569565709 790 3915356
SGTC_708 3448-5400 146 µM -0.577500275657769 0.258008401313103 no 2519 0.281800776232389 804 3462195
SGTC_1804 st050076 49.1 µM -0.578415594446759 0.257674260829194 no 2520 0.281491783992156 781 3895976
SGTC_2080 5212524 12.4 µM -0.578690327052776 0.257574012538755 no 2521 0.281399071985726 796 260183
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.579269545046897 0.257362725732086 no 2522 0.281203655817172 780 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1877 wortmannin 25 µM -0.580941170808938 0.256753456474842 no 2523 0.280640051624854 791 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2423 st077119 87.2 µM -0.58222365699349 0.256286529190733 no 2524 0.280208020266639 773 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3016 9080866 49.47 µM -0.583689561183333 0.255753365744093 no 2525 0.279714595830375 801 17066299
SGTC_586 0957-0265 8.15 µM -0.583701252831995 0.255749115707914 no 2526 0.279710662108184 782 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_113 0099-0221 2.5 µM -0.584422011587995 0.255487183603641 no 2527 0.279468210547098 796 89219
SGTC_2302 7771753 200 µM -0.584536335619824 0.255445649805191 no 2528 0.279429763176249 774 2203047
SGTC_2802 7925815 54.55 µM -0.58583974219303 0.254972373117597 no 2529 0.278991606981064 783 1262923
SGTC_2247 cerulenin 830 nM -0.586160686975285 0.254855906100122 no 2530 0.278883768730052 767 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2413 inermin 26.06 µM -0.58663053570205 0.254685453859177 no 2531 0.278725934968161 787 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2902 5787006 60.46 µM -0.587517842294712 0.254363718691234 no 2532 0.27842798548056 782 591003
SGTC_3103 9120822 49.47 µM -0.587917347696557 0.254218928606663 no 2533 0.278293885886474 811 17141819
SGTC_824 1304-0008 100 µM -0.588426783948324 0.254034359725815 no 2534 0.278122932146087 778 768245
SGTC_1752 st044819 83.042 µM -0.589334767778615 0.253705571356103 no 2535 0.277818363125317 779 441209 YML126C ERG13
SGTC_1927 st060202 13.8 µM -0.589431290424299 0.253670632861705 no 2536 0.277785995686582 798 688887
SGTC_194 1486-1323 56.904 µM -0.590013227091228 0.25346004164102 no 2537 0.277590890875195 800 5178754
SGTC_1090 efavirenz 20.7 µM -0.590200185974316 0.253392404471116 no 2538 0.27752822373569 775 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1579 chlormadinone acetate 49.4 µM -0.591230573874252 0.253019805512698 no 2539 0.277182969962821 796 45114258 A steroidal progestin.
SGTC_1444 4112-3581 28 µM -0.591347372663706 0.25297758805601 no 2540 0.277143847263355 789 2877249
SGTC_3295 9122362 53.5725 µM -0.592134861094422 0.252693043535408 no 2541 0.27688014218408 806 4730473
SGTC_2257 7960413 200 µM -0.592806980727248 0.252450318802629 no 2542 0.276655167718774 789 2974689 YIL048W NEO1
SGTC_3027 9089541 49.47 µM -0.593201655519108 0.252307845900557 no 2543 0.276523102416299 792 9943819
SGTC_1770 st043884 66.3 µM -0.593218991192716 0.252301588900754 no 2544 0.276517302295994 819 670149
SGTC_981 1488-1094 54.9 µM -0.593416248446602 0.252230398202207 no 2545 0.276451308726796 798 3449522
SGTC_1608 st001473 40.5 µM -0.593901927354696 0.252055160474305 no 2546 0.27628885493117 823 7292267
SGTC_1967 st070177 51.4 µM -0.595483077200038 0.251485111291633 no 2547 0.275760303865255 805 5729214
SGTC_827 3253-0474 693 µM -0.595913419825948 0.251330078646395 no 2548 0.275616533842886 804 5402065
SGTC_221 trifluoperazine 10.304 µM -0.595947287760423 0.251317879733101 no 2549 0.275605220716772 816 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2175 5807670 165.306 µM -0.596468902174005 0.251130038642811 no 2550 0.275431011311034 777 241186
SGTC_493 zm226600 134 µM -0.596600570014429 0.251082634841434 no 2551 0.275387045293293 818 5240098 A potassium channel opener. YCR052W RSC6
SGTC_949 1165-0505 146 µM -0.596797625791994 0.251011698549455 no 2552 0.275321251639778 781 6244267
SGTC_3241 9133421 49.47 µM -0.59712707353397 0.250893127383892 no 2553 0.275211271787947 818 17018221
SGTC_346 4513-0042 7.16 µM -0.597230776877056 0.250855809766319 no 2554 0.275176656878956 780 2827372
SGTC_2415 st077333 57.7 µM -0.599215486133326 0.250142179318433 no 2555 0.274514598580714 809 2766255
SGTC_3304 9125678 46.087 µM -0.599224655030257 0.250138885011764 no 2556 0.274511541849518 803 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2825 7998094 58.44 µM -0.599650878359768 0.249985771997858 no 2557 0.274369465853104 787 2987815
SGTC_1408 3909-7976 48.8 µM -0.599802852302182 0.249931190141175 no 2558 0.274318816098571 792 24152374
SGTC_954 1189-0853 2.85 µM -0.599848830265645 0.249914678276285 no 2559 0.274303493509134 812 2828194
SGTC_1159 4092-0538 61.2 µM -0.601328152291327 0.249383724971537 no 2560 0.273810721154733 805 717301
SGTC_3123 9126162 49.47 µM -0.6019958710561 0.249144266135701 no 2561 0.273588442912416 777 25239884
SGTC_1754 st042065 16.137 µM -0.603004880851281 0.248782644895087 no 2562 0.273252721120618 802 1126236 YIL048W NEO1
SGTC_2060 5238662 140 µM -0.604269077552708 0.24832996137029 no 2563 0.272832380743844 804 790130
SGTC_668 1682-0499 62.6 µM -0.606014561825368 0.247705660816094 no 2564 0.272252541794375 814 682214
SGTC_399 oxolinic acid 75 µM -0.607648028633191 0.247122185157666 no 2565 0.271710469597415 773 4628 A DNA gyrase inhibitor.
SGTC_64 000l-0018 272.079 µM -0.608212793315264 0.246920621915404 no 2566 0.271523175345722 801 6811119
SGTC_1041 0206-0046 107 µM -0.609092686172344 0.246606765541882 no 2567 0.271231502578275 818 50494
SGTC_614 0462-0418 107 µM -0.609563659666481 0.246438857891512 no 2568 0.271075445337727 782 5188303
SGTC_2035 5154463 94.595 µM -0.610470386512523 0.246115771576183 no 2569 0.270775127220442 818 2769623
SGTC_2754 granisetron 64.02 µM -0.610589576340132 0.246073318573126 no 2570 0.270735662565906 812 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3327 9140648 26.9345 µM -0.611016213813984 0.245921391144472 no 2571 0.270594423208841 813 8029710
SGTC_1303 1160-0052 261 µM -0.611408709544913 0.245781666205047 no 2572 0.270464519069773 797 3562476
SGTC_2178 5812956 200 µM -0.612286187620706 0.245469446134259 no 2573 0.270174213293994 802 5403383
SGTC_2394 5221648 200 µM -0.612299656247463 0.245464655452781 no 2574 0.270169758533971 801 788586
SGTC_1076 itraconazole 331 nM -0.613368333650979 0.245084695735975 no 2575 0.26981640969696 786 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3073 9114972 49.47 µM -0.613417416973709 0.245067252154146 no 2576 0.269800186285111 783 41905075
SGTC_2380 9035439 200 µM -0.613752519907554 0.244948178725191 no 2577 0.269689438439394 795 6462575
SGTC_991 3996-0057 64.7 µM -0.615055502893099 0.244485480709985 no 2578 0.269259033365624 789 715343
SGTC_1921 5740136 50 µM -0.615558335658184 0.244307047416695 no 2579 0.26909302838401 816 1774243
SGTC_3011 9081274 71.4286 µM -0.615660989753652 0.244270628610435 no 2580 0.269059144521185 796 6625322
SGTC_2481 5478948 45.16 µM -0.617191968356952 0.243727827612192 no 2581 0.268554056343088 791 77792
SGTC_1334 1486-0610 236 µM -0.618087677809321 0.243410560373305 no 2582 0.268258772209037 789 3742339
SGTC_1081 sertraline 6 µM -0.619537368030402 0.242897542051063 no 2583 0.267781206330725 809 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1704 st028805 70.8 µM -0.61987132275802 0.242779444665154 no 2584 0.267671253642765 804 2876101
SGTC_3298 9116858 71.43 µM -0.621906318672788 0.242060475256614 no 2585 0.267001735015558 836 2506942
SGTC_1425 4048-4433 7.33 µM -0.622695902055266 0.241781824594038 no 2586 0.26674218807952 845 23734946
SGTC_1652 st011932 78 µM -0.624428916161297 0.241170840059177 no 2587 0.266172969913546 816 1551076
SGTC_3256 9138902 49.47 µM -0.624580259571883 0.241117522906083 no 2588 0.266123289539186 828 17228773
SGTC_1977 st070720 65.3 µM -0.625193636546603 0.240901500409892 no 2589 0.265921988937398 787 682188
SGTC_2606 farnesol 9.78 µM -0.625368235978988 0.240840028270811 no 2590 0.265864702280433 823 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_454 lyso-paf C-16 6.67 µM -0.626151699068024 0.240564295401733 no 2591 0.265607722441757 823 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2029 5175081 200 µM -0.629392587420999 0.239425521744274 no 2592 0.264546034812705 799 1380876
SGTC_2536 dehydroabietamide 32.04 µM -0.629602253677077 0.239351951366478 no 2593 0.264477424354561 803 3983547
SGTC_1781 st038725 66.3 µM -0.630270433500059 0.239117574285791 no 2594 0.264258831936628 798 4270275 YIL048W NEO1
SGTC_1223 0764-0573 147 µM -0.630970043542209 0.238872306932154 no 2595 0.264030055879396 807 1609797
SGTC_2903 5923464 63.88 µM -0.631892021528805 0.238549292687757 no 2596 0.263728718584433 813 2876576
SGTC_1514 1189-1591 158 µM -0.631947948194777 0.238529706519875 no 2597 0.263710445278013 836 767698 YMR146C TIF34
SGTC_2813 7971799 71.43 µM -0.632817218675347 0.238225391107112 no 2598 0.263426505571732 803 2234054
SGTC_3238 9133470 49.47 µM -0.634415706150781 0.237666346010516 no 2599 0.262904781095293 792 3534688
SGTC_1222 0366-0074 1.18 µM -0.634503133481107 0.237635790492682 no 2600 0.262876261254117 811 286520
SGTC_198 3454-2873 16.191 µM -0.637785512398665 0.236490172589394 no 2601 0.261806655807501 813 710957
SGTC_511 blebbistatin 171 µM -0.637959504505875 0.236429530704753 no 2602 0.261750020605528 811 3476986 A myosin inhibitor.
SGTC_2993 9054257 71.4286 µM -0.638752698074776 0.236153185538533 no 2603 0.261491912248803 816 6470217 YGL055W OLE1
SGTC_783 0848-0141 92.7 µM -0.640180365315004 0.235656241147985 no 2604 0.261027673119331 822 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_137 0438-0332 85.389 µM -0.641127456162674 0.235326894941864 no 2605 0.260719938511469 835 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_513 4245-1575 41.7 µM -0.641311649371123 0.235262872181426 no 2606 0.260660111009095 812 719745
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.642349210487843 0.234902411422369 no 2607 0.260323234490994 824 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1432 4049-0298 68.4 µM -0.642874882133513 0.23471990355259 no 2608 0.260152644475239 818 741646
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.643583719367079 0.234473926632383 no 2609 0.259922705162561 831 279621
SGTC_3069 9117009 49.47 µM -0.643667432804806 0.23444488626005 no 2610 0.259895556330255 798 41904981
SGTC_2786 7743617 45.45 µM -0.643693600549139 0.234435809021303 no 2611 0.259887070254422 801 583674
SGTC_3155 9099265 49.47 µM -0.645214675846247 0.233908502755442 no 2612 0.259394038472496 822 25236499
SGTC_2499 avocadenofuran 51.48 µM -0.646210525130465 0.23356363116135 no 2613 0.259071512074687 821 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2680 butyl paraben 22.24 µM -0.64671707311921 0.233388317273509 no 2614 0.25890753562734 850 7184 An antifungal and steroid mimetic.
SGTC_1762 st045503 25.4615 µM -0.647541197062251 0.233103247911932 no 2615 0.258640870323999 814 4645554
SGTC_2238 6671620 73.2395 µM -0.648398290156292 0.232806979516948 no 2616 0.258363687973336 785 729941
SGTC_2822 7994718 71.43 µM -0.64866069308675 0.232716317457492 no 2617 0.258278858127263 851 1018011
SGTC_344 k064-0035 6.43 µM -0.649107067647341 0.232562136995458 no 2618 0.258134586945044 805 5088750
SGTC_160 3453-0671 289.699 µM -0.651012545371954 0.231904612603069 no 2619 0.257519194286274 834 5322268
SGTC_752 1896-0090 130 µM -0.65120995706481 0.23183655086497 no 2620 0.257455481842402 818 772567
SGTC_3321 9137793 26.8275 µM -0.65343686346001 0.231069550296498 no 2621 0.256737340024951 819 4904192
SGTC_3021 9087658 49.47 µM -0.654165464358194 0.23081891030513 no 2622 0.256502604468109 810 25237042
SGTC_338 4055-0136 114 µM -0.654356231507291 0.230753311160078 no 2623 0.256441162912542 811 2900563
SGTC_2970 9090938 41.86 µM -0.655083726867926 0.230503242760119 no 2624 0.256206924383625 806 17217104
SGTC_2890 9046729 58.44 µM -0.656829202575888 0.229903873119889 no 2625 0.255645372393064 826 903329
SGTC_3301 9125354 19.7965 µM -0.658993854483026 0.229161778153489 no 2626 0.254949857508785 794 41905162
SGTC_1051 3253-3903 78 µM -0.659445866360282 0.229006987287659 no 2627 0.254804748607134 823 5509239
SGTC_1278 0874-0585 172 µM -0.659650152595728 0.2289370489899 no 2628 0.254739180998529 811 766306
SGTC_2358 9037157 4 µM -0.660047962816541 0.228800891299716 no 2629 0.254611525383166 820 2388925
SGTC_869 0564-0080 44.1 µM -0.660411076454404 0.228676648830841 no 2630 0.254495033011496 799 6843321
SGTC_1194 1488-0194 225 µM -0.660590295202075 0.228615341553638 no 2631 0.254437547209137 821 1391452
SGTC_928 2764-0428 58.7 µM -0.662142136683631 0.228084872688819 no 2632 0.253940066723041 828 662578
SGTC_978 1416-0512 87.4 µM -0.666470017164374 0.226609128355685 no 2633 0.252555360955786 832 6814003
SGTC_1740 st038286 13.222 µM -0.666500188035319 0.226598859479927 no 2634 0.252545721764714 811 716786
SGTC_1309 pyrazolanthrone 13.4 µM -0.666981259963134 0.226435158632897 no 2635 0.252392051885214 830 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2088 5278280 127.392 µM -0.667803951398782 0.226155365114975 no 2636 0.252129371977456 824 791502
SGTC_784 4579-0127 173 µM -0.668974551820631 0.225757586347692 no 2637 0.251755855762712 830 1948547
SGTC_200 k038-0079 37.545 µM -0.670638172398724 0.225192957121864 no 2638 0.251225529345097 843 3436683
SGTC_1380 2291-0730 164 µM -0.670958655893904 0.225084277682711 no 2639 0.251123434014943 814 2999191
SGTC_576 1073-0113 22.7 µM -0.670983974005392 0.225075693302502 no 2640 0.251115369446319 853 5439563
SGTC_3102 9121669 49.47 µM -0.672210326235534 0.224660107457624 no 2641 0.250724904014737 832 41905072
SGTC_2801 7907800 81.82 µM -0.672800123858529 0.22446039213253 no 2642 0.250537229475906 833 6620925
SGTC_588 3970-1144 52.9 µM -0.673557853679232 0.224203960089033 no 2643 0.250296227926319 802 1888707
SGTC_432 NS 1619 61.3 µM -0.673570748986166 0.224199597480363 no 2644 0.250292127542949 820 4552 A K+/calcium channel activator.
SGTC_2995 9067767 71.4286 µM -0.675282882118885 0.223620794306735 no 2645 0.249748028685521 811 11673567
SGTC_227 fluconazole 33.516 µM -0.675492352861157 0.223550039082277 no 2646 0.249681504117494 839 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_781 4335-2806 94.4 µM -0.675805848291412 0.223444170093156 no 2647 0.249581960551806 851 845254
SGTC_3097 9117246 49.47 µM -0.676068864148028 0.223355370319494 no 2648 0.249498461929521 817 16423892
SGTC_282 k297-0036 65.7 µM -0.676864898580531 0.223086734482955 no 2649 0.249245838445827 834 5061378
SGTC_1331 1472-0049 76.2 µM -0.677706626911287 0.222802878662756 no 2650 0.248978861912806 841 24051409
SGTC_2552 juarezic acid 87.02 µM -0.67808445276333 0.222675531505128 no 2651 0.248859073894961 818 1549512
SGTC_3171 9103192 49.47 µM -0.678722883734255 0.222460441045569 no 2652 0.248656731912704 830 13018434
SGTC_2248 tofa 1.1 µM -0.680620636692666 0.221821779009595 no 2653 0.248055782747639 830 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3221 9128209 49.47 µM -0.681910946807137 0.221388142089695 no 2654 0.247647631521759 839 16460723
SGTC_3143 9086658 49.47 µM -0.68239810957038 0.221224546532236 no 2655 0.247493625401326 835 25236626
SGTC_464 bw-b 70c 158 µM -0.683506039176718 0.220852747024234 no 2656 0.247143567699007 845 5353454
SGTC_2836 9010338 19.48 µM -0.683759025442583 0.220767899982044 no 2657 0.247063672165682 819 2994051
SGTC_2309 7664088 163.95 µM -0.683766868287935 0.220765269931165 no 2658 0.247061195539363 825 704922
SGTC_39 0986-0283 58.349 µM -0.684277954848855 0.220593918823598 no 2659 0.246899832439833 801 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1803 st050068 52.4 µM -0.684879323244617 0.220392396690289 no 2660 0.246710037311148 839 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_3263 9137018 49.47 µM -0.68793174557601 0.219371140369977 no 2661 0.245747882134397 833 43844957
SGTC_1481 3346-2004 36 µM -0.688361542005316 0.219227561061176 no 2662 0.245612567832126 855 2770522
SGTC_3352 9151559 45.5865 µM -0.68909215139386 0.21898361511695 no 2663 0.245382639402454 817 17159339
SGTC_2726 cimetidine 79.27 µM -0.689475565779061 0.218855657923183 no 2664 0.245262022226533 842 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1717 st033143 58.0435 µM -0.689929173375717 0.218704330658049 no 2665 0.245119364351309 833 674616
SGTC_665 3914-0008 307 µM -0.691414692070947 0.218209171037077 no 2666 0.244652486884587 835 1069549
SGTC_1485 3909-9022 254 µM -0.691652421889801 0.218129989895566 no 2667 0.244577816246586 841 714516
SGTC_2566 crystal violet carbinol 226 nM -0.692243823968535 0.217933082290643 no 2668 0.244392110859206 862 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2724 maprotiline 69.64 µM -0.692282561324848 0.217920188246986 no 2669 0.24437994964509 838 4011 A tricyclic antidepressant.
SGTC_1015 4130-4525 82 µM -0.692956979117887 0.217695773317464 no 2670 0.244168275048498 840 1363237
SGTC_2479 5617353 43.85 µM -0.695313763486421 0.216912592814865 no 2671 0.24342934533716 843 2731746
SGTC_964 1287-0107 19.4 µM -0.695322764951074 0.216909604673296 no 2672 0.243426525398802 825 51516812 YPR165W RHO1
SGTC_2629 bisabolol 100 µM -0.695825441374221 0.216742773120822 no 2673 0.243269077206873 852 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1089 terbinafine 2.25 µM -0.695861352806935 0.216730857439267 no 2674 0.243257831143388 845 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3117 9124945 49.47 µM -0.696303058759906 0.216584327094593 no 2675 0.243119529013379 821 17592065
SGTC_2350 9023895 38.85 µM -0.696410744746363 0.216548612326404 no 2676 0.24308581800445 830 2997209
SGTC_726 3448-4391 34.2 µM -0.696461785530966 0.216531685503602 no 2677 0.243069840612142 834 1356692
SGTC_1915 st067105 30.6 µM -0.698386817910123 0.21589383981466 no 2678 0.242467658972909 841 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2369 9071472 200 µM -0.698647982384862 0.215807388790629 no 2679 0.24238602475049 844 17296037
SGTC_3087 9117406 49.47 µM -0.69878823198553 0.21576097145635 no 2680 0.242342191982432 818 42546093
SGTC_3274 9138298 49.47 µM -0.698981863528931 0.215696896221305 no 2681 0.242281682601886 841 17015756
SGTC_697 0508-1955 564 µM -0.699116449715959 0.215652366373851 no 2682 0.242239629573846 830 6243113
SGTC_1685 st024049 53.0905 µM -0.700640532432332 0.21514847294131 no 2683 0.241763688297836 837 1941139
SGTC_1390 3413-2614 145 µM -0.701577360416821 0.214839077611679 no 2684 0.241471387250532 854 3421432
SGTC_1468 k284-1086 134 µM -0.70170824744433 0.214795871656744 no 2685 0.241430564288419 831 15996457
SGTC_445 e6 berbamine 66 µM -0.701917146847636 0.214726924188169 no 2686 0.241365417451794 845 6610268 A calcium/calmodulin antagonist.
SGTC_219 mitoxanthrone 164.414 µM -0.705635103774549 0.213501961479158 no 2687 0.240207544032928 856 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2975 9084847 53.72 µM -0.706247166373943 0.213300695108717 no 2688 0.240017221613232 829 27211724
SGTC_1042 0350-0096 82 µM -0.708336048500634 0.212614635335701 no 2689 0.239368298006087 844 3122515
SGTC_182 3448-4371 550.524 µM -0.710515818300263 0.211900100842357 no 2690 0.238692162610935 807 3491403
SGTC_2992 9074591 71.4286 µM -0.711367589689845 0.211621270014481 no 2691 0.238428238773399 845 17741321
SGTC_197 4544-0043 41.561 µM -0.711955949258938 0.211428793595847 no 2692 0.238246027201355 839 896523
SGTC_2292 7671323 168.05 µM -0.712827246312213 0.211143945196181 no 2693 0.23797633170692 860 937504
SGTC_3338 9144300 39.5675 µM -0.71403549120339 0.210749312676401 no 2694 0.237602616749687 827 4901274
SGTC_2721 ifenprodil 61.44 µM -0.715174628932598 0.210377648219366 no 2695 0.237250572061822 848 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2197 6588183 93.1375 µM -0.716715534001061 0.209875512639752 no 2696 0.236774819463207 828 884136
SGTC_1677 st019204 53.9 µM -0.718156874581841 0.209406460462265 no 2697 0.236330282597252 835 3945625
SGTC_2727 riluzole 51.77 µM -0.718639387084473 0.209249575436193 no 2698 0.2361815692874 852 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1056 3448-1962 115 µM -0.72010545914173 0.208773318667344 no 2699 0.235730033282142 846 715507
SGTC_1038 k292-0204 154 µM -0.720170963845276 0.208752054237224 no 2700 0.235709869583418 844 4454212
SGTC_2312 7706453 155.7 µM -0.721933820130068 0.20818026747428 no 2701 0.235167583446356 838 976098
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.723034268614564 0.207823803315966 no 2702 0.234829415405457 850 75037 A free radical scavenger.
SGTC_45 0kpi-0036 14.9 µM -0.724250374519646 0.207430294282355 no 2703 0.234456018671467 842 2795021
SGTC_2144 5628481 200 µM -0.72718473571247 0.206482605560761 no 2704 0.233556397846336 837 2818399
SGTC_2181 6316240 54.2555 µM -0.728038660896891 0.206207302302894 no 2705 0.233294960242957 857 12779990
SGTC_2595 hexamethylquercetagetin 100 µM -0.72895071435393 0.205913499090876 no 2706 0.233015905548773 864 386331
SGTC_2704 st078022 71.1 µM -0.72924822333102 0.205817715142644 no 2707 0.232924918893814 845 54697681
SGTC_1079 idarubicin 2.36 µM -0.729441608366692 0.205755468403227 no 2708 0.232865786868098 867 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3351 9150312 21.596 µM -0.729519869048351 0.205730281045147 no 2709 0.232841859193559 845 4904905
SGTC_545 4218-0007 221 µM -0.730747157205101 0.205335530957902 no 2710 0.232466802863675 853 2840508
SGTC_1943 st076331 65.2 µM -0.731495539414576 0.205095039157232 no 2711 0.232238264048437 847 24208415
SGTC_1383 3049-0032 20.7 µM -0.731613595322958 0.205057117313031 no 2712 0.232202223893343 863 712864
SGTC_2306 7482397 179.52 µM -0.731854585015634 0.204979719694334 no 2713 0.232128664125779 878 891448
SGTC_2476 5806916 10.51 µM -0.733097746584579 0.204580734808884 no 2714 0.231749407216497 838 2870194
SGTC_2817 7995342 71.43 µM -0.734047280072471 0.204276299511328 no 2715 0.231459961453617 855 18879975
SGTC_3282 9108498 15.4605 µM -0.734994103148531 0.203973001971024 no 2716 0.231171542715369 853 16459645
SGTC_400 oxethazaine 37.5 µM -0.736329428931511 0.203545711015334 no 2717 0.230765120365723 848 4621 A local anesthetic.
SGTC_1281 0884-0031 11.8 µM -0.736549576833869 0.203475317176999 no 2718 0.230698154066305 860 1548255
SGTC_294 k038-0071 157 µM -0.736711174664048 0.203423654379221 no 2719 0.230649004892836 858 24152826
SGTC_972 1319-0219 195 µM -0.736886550884968 0.203367595488314 no 2720 0.230595671711091 855 23903702
SGTC_1682 st012968 530 nM -0.742146309539403 0.201690604494633 no 2721 0.228999347191051 840 24207270
SGTC_367 0335-0881 7.1 µM -0.742966303074639 0.201429910815467 no 2722 0.228751040912938 862 23828853
SGTC_2792 7535235 81.82 µM -0.743654900255921 0.201211146950975 no 2723 0.228542640229324 850 1281891
SGTC_56 0957-0365 83.25 µM -0.743868580348198 0.201143290832333 no 2724 0.228477992647305 849 6752360
SGTC_305 1682-2595 20.8 µM -0.744982349419459 0.200789825250105 no 2725 0.228141195130487 852 226033
SGTC_1461 k072-0203 53.8 µM -0.747144981503624 0.200104558248421 no 2726 0.227488025282054 849 5418714
SGTC_2293 7624732 200 µM -0.748220147598561 0.199764397285535 no 2727 0.22716369017172 838 894453
SGTC_2485 5633444 17.78 µM -0.749941067948465 0.199220657163739 no 2728 0.226645099415727 840 5724239
SGTC_452 diindolylmethane 8 µM -0.750100609470233 0.19917029378817 no 2729 0.226597056242447 831 3071 Inhibits expression of several cancer promoting factors.
SGTC_2532 xanthone 78.9 µM -0.751745494680375 0.198651490836148 no 2730 0.226102062766658 835 7020 An insecticide.
SGTC_1329 1447-1697 50.6 µM -0.751877634415621 0.198609848863482 no 2731 0.226062324639239 855 2840515
SGTC_1731 st035964 63 µM -0.753632627710132 0.198057286930435 no 2732 0.225534923421633 894 6739575
SGTC_2407 paclitaxel 400 µM -0.756274326117019 0.197227297223559 no 2733 0.224742368907586 888 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2938 9059746 27.26 µM -0.760559727781017 0.195885359665811 no 2734 0.223460040834204 871 6471769
SGTC_350 k064-0020 19.8 µM -0.761450639847011 0.195607075251079 no 2735 0.223193975275631 847 2790705
SGTC_1596 piperlongumine 63 µM -0.761625197451929 0.19555257874605 no 2736 0.223141865828104 839 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3290 9121031 71.43 µM -0.763875716439687 0.19485079757571 no 2737 0.222470654938853 847 17014854
SGTC_467 ro 31-8220 72.8 µM -0.764011674147309 0.194808450891335 no 2738 0.222430142853001 856 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2346 9031566 143.75 µM -0.765018631331882 0.194494988693904 no 2739 0.222130225149947 859 4771086
SGTC_585 0kpi-0023 191 µM -0.766892604112172 0.193912445509916 no 2740 0.221572685657148 831 64601
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.766929685583789 0.193900929102729 no 2741 0.221561661350369 829 279621
SGTC_179 1273-0063 6.77 µM -0.767925501862362 0.193591813976366 no 2742 0.221265722846567 872 3108139
SGTC_1348 1493-0373 93.8 µM -0.771557033246616 0.192467085218756 no 2743 0.220188415358526 877 3010129
SGTC_1679 SEC14.276 6.7 µM -0.772902681010172 0.192051338471274 no 2744 0.219789988975923 851 1005053 YMR079W SEC14
SGTC_2544 sphondin 68.51 µM -0.773356087786602 0.19191137932897 no 2745 0.219655835213266 844 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2377 9073351 62.6 µM -0.774946660743572 0.191420889748547 no 2746 0.219185589275344 886 7337946 YHR072W ERG7
SGTC_1923 st058458 19.1 µM -0.775264786956614 0.191322880512653 no 2747 0.219091606152312 881 3534982
SGTC_2720 fluspirilene 36.88 µM -0.77527673313271 0.191319200699734 no 2748 0.219088077378932 876 3396 An atypical antipsychotic.
SGTC_1663 st014140 55.4 µM -0.775572302586671 0.191228169456273 no 2749 0.219000779713385 860 4207120
SGTC_2186 6124449 200 µM -0.775908707043938 0.191124593919518 no 2750 0.218901445607276 840 3834182 YLR033W RSC58
SGTC_2081 5214970 32.255 µM -0.777901012860741 0.190511888452212 no 2751 0.21831368556727 870 2063512
SGTC_1008 4106-0037 6 µM -0.777927791349853 0.190503661329126 no 2752 0.218305791709352 870 2905394
SGTC_1847 st056231 15 µM -0.779458787703595 0.190033657975357 no 2753 0.217854752703693 851 5393180
SGTC_1914 st062367 72.6 µM -0.779642184506736 0.189977404497119 no 2754 0.217800759179628 879 978205
SGTC_1855 st056195 39.6 µM -0.779921229230727 0.189891832478157 no 2755 0.217718620931506 844 4028379
SGTC_2132 5317594 122.667 µM -0.781649563580564 0.189362348558838 no 2756 0.217210275133508 883 794577
SGTC_1491 4138-0063 26.5 µM -0.781982733095122 0.189260384974179 no 2757 0.217112360635036 856 23883227
SGTC_566 0958-0068 16.5 µM -0.782396175415488 0.189133901615558 no 2758 0.216990890393599 852 6815365
SGTC_2094 5332512 191.667 µM -0.783940357587065 0.188661954345994 no 2759 0.216537553804465 866 755774
SGTC_1322 1348-1070 12 µM -0.784872098009701 0.188377538691632 no 2760 0.216264281391546 848 6758089
SGTC_2280 7785178 200 µM -0.786246196422387 0.187958575294583 no 2761 0.215861633305452 862 2954328
SGTC_2156 5649887 115 µM -0.786256786559424 0.18795534859126 no 2762 0.215858531796156 880 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3283 9109332 35.8195 µM -0.78959711090357 0.186939294060555 no 2763 0.214881548023516 844 17027281
SGTC_3235 9132602 49.47 µM -0.789719710320553 0.186902066737412 no 2764 0.214845738870489 857 4912240
SGTC_496 calpeptin 138 µM -0.790639642522574 0.186622875624102 no 2765 0.214577153325395 864 73364 A calpain inhibitor.
SGTC_1689 st020265 53.493 µM -0.79125875015575 0.186435127497055 no 2766 0.214396507150158 869 5758320 YPR016C TIF6
SGTC_2389 9091542 195.52 µM -0.795618632591359 0.185116282158843 no 2767 0.213126866652625 855 3626624 YOL127W RPL25
SGTC_1229 0139-0193 12.2 µM -0.795665663559504 0.185102087164575 no 2768 0.213113194726611 871 3090752
SGTC_1180 1193-0155 285 µM -0.795671239073103 0.185100404395153 no 2769 0.213111573955933 873 2921347
SGTC_1117 retinoic acid 1.10837 µM -0.795749351594146 0.185076829922838 no 2770 0.213088867838144 864 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2732 terfenadine 20 µM -0.796151995725986 0.184955340927688 no 2771 0.212971847722201 885 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2241 6772625 37.8075 µM -0.796278720984381 0.184917114627863 no 2772 0.212935025429507 865 2285411
SGTC_330 1488-0319 80.1 µM -0.796815634858945 0.184755210616059 no 2773 0.212779056712028 855 6846614
SGTC_561 1550-0330 72.9 µM -0.798018254957437 0.184392885692382 no 2774 0.212429948330132 858 6812934
SGTC_8 0354-0001 70 µM -0.799071645668455 0.184075883982956 no 2775 0.212124434844603 866 4993152
SGTC_2882 9058044 58.44 µM -0.800598309931881 0.183617060457901 no 2776 0.211682114734825 855 18076804
SGTC_332 4112-0506 40.9 µM -0.801745997410018 0.183272604261191 no 2777 0.211349951225561 873 2790355
SGTC_2496 diffractaic acid 79.83 µM -0.801755960005103 0.183269615946222 no 2778 0.21134706919028 879 94870 An apoptosis inducer which activates caspases.
SGTC_1456 k015-0012 13 µM -0.801953409261506 0.183210396625427 no 2779 0.211289954713387 875 2989616
SGTC_777 1315-0167 517 µM -0.80408085180009 0.182573087644423 no 2780 0.210675141197856 852 4221767
SGTC_925 2064-1272 59.6 µM -0.805950383690119 0.182014184269199 no 2781 0.210135729177327 885 6815817
SGTC_2949 9072542 2.23 µM -0.8073080597825 0.181608973340265 no 2782 0.209744510824662 901 16457352
SGTC_732 3970-1727 52.7 µM -0.809994978029284 0.180808703571216 no 2783 0.208971531032722 865 1275699
SGTC_89 0302-0250 142.109 µM -0.810311994906141 0.18071442950488 no 2784 0.20888044156901 894 4203518 YLR208W SEC13
SGTC_2446 5162541 200 µM -0.81103132421821 0.180500630617712 no 2785 0.208673841176515 875 1549321
SGTC_604 1000-0114 314 µM -0.811380759912885 0.180396828704448 no 2786 0.208573522348323 881 1572745
SGTC_1374 2889-5571 141 µM -0.811687227664517 0.180305821503218 no 2787 0.208485562513409 862 2853281
SGTC_1205 4161-2785 76 µM -0.811811802484711 0.180268836596112 no 2788 0.208449814334445 877 3498106
SGTC_2215 7188065 200 µM -0.813945214235777 0.179636188972217 no 2789 0.207838168504287 876 940217
SGTC_423 5-fluorouracil 457 µM -0.814129927015134 0.179581479456518 no 2790 0.207785261541191 869 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1617 st002906 78 µM -0.814148908215172 0.17957585806606 no 2791 0.207779825239525 889 5150859
SGTC_2171 5739187 198.077 µM -0.817318773864478 0.178638635998879 no 2792 0.206873140357345 858 2262761
SGTC_1411 3909-8223 150 µM -0.817377777982442 0.178621219728618 no 2793 0.206856285487913 878 X1411
SGTC_2398 5228213 48.84 µM -0.818511363275124 0.178286826509837 no 2794 0.206532628102759 875 80771 YMR134W ERG29
SGTC_2846 9008642 19.48 µM -0.819444829973064 0.178011762105876 no 2795 0.20626633324534 899 2992898
SGTC_2587 piperic acid 92.2 µM -0.820693300534912 0.177644294099849 no 2796 0.205910493904129 857 5370536
SGTC_336 4111-0029 111 µM -0.822307040559959 0.177170024446501 no 2797 0.205451085342178 877 3131175
SGTC_2384 9036245 200 µM -0.82397210100526 0.176681511150354 no 2798 0.204977705195583 856 6462766
SGTC_1366 1683-0113 21.9 µM -0.825396776878081 0.176264201246554 no 2799 0.204573182097777 890 708623
SGTC_1763 st044482 94.5 µM -0.825878839443778 0.176123138911854 no 2800 0.204436412672802 874 88505
SGTC_2697 mebhydrolin 72.4 µM -0.827892574706397 0.175534647789908 no 2801 0.203865670230764 896 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1316 1272-0050 65.9 µM -0.830076658513819 0.174897784826022 no 2802 0.20324772157864 885 7340392
SGTC_339 3091-4833 71.4 µM -0.830099338639246 0.174891179168224 no 2803 0.203241310500629 876 3240077
SGTC_518 1021-0119 62.6 µM -0.832489658389329 0.174195878825205 no 2804 0.202566306549596 899 1097762
SGTC_495 decylubiquinone 155 µM -0.832877857053223 0.174083124971926 no 2805 0.202456809503389 883 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2206 7254556 146.969 µM -0.833131680478613 0.174009426033961 no 2806 0.202385234074493 868 4398905
SGTC_2397 5161689 200 µM -0.833522304601723 0.173896045070064 no 2807 0.2022751119137 890 2259942
SGTC_1513 0337-0559 19 µM -0.836076839531831 0.173155734781108 no 2808 0.20155583840692 879 775073
SGTC_309 k408-0051 1.48 µM -0.836161891597201 0.173131121068055 no 2809 0.201531916915615 872 3640463
SGTC_2311 7694451 200 µM -0.836254153909538 0.173104423259562 no 2810 0.201505969415271 879 2163142
SGTC_1357 1503-1303 39.5 µM -0.83678004416724 0.172952297251776 no 2811 0.201358108275245 865 292895
SGTC_3037 9091026 49.47 µM -0.838203257535328 0.17254102698195 no 2812 0.200958278922375 879 25236398 YIL048W NEO1
SGTC_3299 9121982 43.1275 µM -0.838238654755793 0.17253080609488 no 2813 0.200948340705852 882 17594604 YPL160W CDC60
SGTC_404 fumagillin 50 µM -0.838879661471272 0.172345783306106 no 2814 0.200768421001521 879 12015870 A methionine aminopeptidase binder.
SGTC_289 k017-0060 526 µM -0.843496054970276 0.171017029170169 no 2815 0.199475535590795 889 5512909
SGTC_735 3076-0345 636 µM -0.847805002887394 0.169782697729885 no 2816 0.198273288225818 880 2888990
SGTC_1484 3473-2379 286 µM -0.848200081700319 0.169669810981908 no 2817 0.198163275881509 919 671917
SGTC_2868 9035608 32.47 µM -0.849074062938557 0.169420257475188 no 2818 0.19792004091257 884 6462614
SGTC_2005 4024620 188 µM -0.853389096543426 0.168191612731075 no 2819 0.196721782997714 889 236743
SGTC_2944 9067346 25.62 µM -0.854344742408088 0.167920283390529 no 2820 0.196457001616655 887 6473075
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.855993868855092 0.167452722358176 no 2821 0.196000585392098 911 689007
SGTC_1800 st050079 29.0735 µM -0.858108234913282 0.166854484792334 no 2822 0.19541635028933 881 3645560
SGTC_1830 st055982 50.3 µM -0.858490445343209 0.166746489704916 no 2823 0.19531085208764 905 455313 An antimicrobial agent.
SGTC_2420 aureobasidin a 50 nM -0.862916733589193 0.165499110788686 no 2824 0.19409162480173 879 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_525 k781-2675 26.7 µM -0.865008240329547 0.164911805471542 no 2825 0.193517132989752 865 3651118 YDL195W SEC31
SGTC_1313 1220-0047 237 µM -0.865647072788829 0.164732687613738 no 2826 0.193341866482534 888 3528706
SGTC_1988 st071872 53.4 µM -0.866433467006048 0.164512369058297 no 2827 0.193126248810782 881 16414116
SGTC_1315 1237-0019 3.69 µM -0.871415746236438 0.163120959073825 no 2828 0.191763595598592 889 825140
SGTC_2431 5490079 200 µM -0.873070994905588 0.162660392394699 no 2829 0.191312191149508 914 5722345
SGTC_2906 7926292 26.41 µM -0.873552428764596 0.162526594200847 no 2830 0.191181021220734 903 2966319
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.87555558309414 0.161970654586321 no 2831 0.190635840436019 889 688761
SGTC_882 0843-0131 351 µM -0.877060237707983 0.1615538803094 no 2832 0.190226960185822 894 5425421
SGTC_1568 digitonin 820 nM -0.877190495846304 0.161517833020194 no 2833 0.190191588729613 914 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2462 5162487 171.77 µM -0.877330030788064 0.161479224311238 no 2834 0.190153702650826 892 2259986
SGTC_2115 tiliquinol 12.7705 µM -0.882290966678224 0.160110465725266 no 2835 0.188809740085222 897 71208 A bioactive hydroxyquinoline.
SGTC_2687 chenodiol 100 µM -0.882937657726884 0.15993259942099 no 2836 0.188634977898332 878 5702181 A cholesterol synthesis inhibitor.
SGTC_47 0149-0135 24.25 µM -0.883251366433736 0.159846363353317 no 2837 0.188550236997353 894 5239155
SGTC_598 3937-0236 20.2 µM -0.884611731018786 0.15947276178013 no 2838 0.188183038715911 908 1379313
SGTC_2782 7736369 71.43 µM -0.885670463477732 0.159182394343155 no 2839 0.187897564488348 905 2950836 YOL077C BRX1
SGTC_1162 k048-0130 20.1 µM -0.886501310882825 0.15895476921316 no 2840 0.187673724040686 888 6797406
SGTC_1714 st033236 13.627 µM -0.886645400448125 0.158915315078581 no 2841 0.187634921318772 911 2916566
SGTC_876 0720-0963 56.8 µM -0.88750207242533 0.158680876469427 no 2842 0.187404325461745 909 765861
SGTC_1523 st012844 44.7 µM -0.888110621505113 0.158514477504255 no 2843 0.187240624890355 912 4274103
SGTC_1251 0490-5699 265 µM -0.889477474435849 0.158141148642939 no 2844 0.186873261961595 887 3883818
SGTC_2023 5144124 124 µM -0.890594538583741 0.157836473531864 no 2845 0.186573365095551 892 2830192
SGTC_2657 nystatin 74.44 µM -0.890830406907034 0.15777219064468 no 2846 0.18651007993894 897 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2783 7738165 71.43 µM -0.8967414219997 0.156166835250356 no 2847 0.184928456015789 901 17201110
SGTC_2669 eugenol 100 µM -0.897492282782076 0.155963684276986 no 2848 0.184728144767754 881 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3175 9106517 49.47 µM -0.898980862133578 0.155561453256939 no 2849 0.184331427256976 911 41468073
SGTC_135 0933-0004 26.348 µM -0.899863093895803 0.155323387477921 no 2850 0.184096556285975 875 21230617 YGL099W LSG1
SGTC_3228 9131799 49.47 µM -0.900206165432835 0.155230876322605 no 2851 0.184005272855498 910 17015818
SGTC_1197 1601-0112 267 µM -0.900348595276352 0.155192480006449 no 2852 0.18396738383634 905 7350313
SGTC_2749 bexarotene 57.39 µM -0.900588878653378 0.155127718491701 no 2853 0.183903474947472 912 82146 An retinoic acid receptor inhibitor.
SGTC_557 1315-0110 16.2 µM -0.901034169408747 0.155007750275869 no 2854 0.183785076191431 900 6833801
SGTC_3148 9097893 49.47 µM -0.902430831499157 0.154631865457356 no 2855 0.183414024587122 872 17174100
SGTC_3355 9151058 44.0485 µM -0.902689839671256 0.154562224641497 no 2856 0.183345265183972 897 17015728
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.905755150012821 0.153739613958661 no 2857 0.18253273234392 888 165521
SGTC_2296 7971656 126.45 µM -0.905952335285295 0.153686796461322 no 2858 0.182480540840017 890 666570
SGTC_163 TUB2.036 7.546 µM -0.906072730589069 0.153654553618392 no 2859 0.18244867888585 893 15992207 YJR013W GPI14
SGTC_1629 st005085 44.9 µM -0.907897791359861 0.153166336037775 no 2860 0.181966112318399 891 24207091
SGTC_1335 1486-0900 202 µM -0.912023062035524 0.152066586919384 no 2861 0.180878288730565 894 X1335
SGTC_1519 esterone 74 µM -0.912435750376707 0.151956858288517 no 2862 0.180769688567709 904 698 A steroid.
SGTC_2429 5902844 64.44 µM -0.915048517330407 0.151263377302655 no 2863 0.180083080143408 900 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_660 4031-1742 102 µM -0.916651604244122 0.150838929408069 no 2864 0.179662616862494 877 6738706
SGTC_922 1866-0035 480 µM -0.917701444380107 0.150561394215955 no 2865 0.179387595644441 896 3156169
SGTC_1337 1486-1011 40.3 µM -0.920783767195042 0.149748519303435 no 2866 0.178581665818832 891 X1337
SGTC_1419 3993-2473 62.6 µM -0.922551978372804 0.149283527844756 no 2867 0.178120365494417 916 704026
SGTC_407 eburnamonine 100 µM -0.92365024824132 0.14899519860454 no 2868 0.177834221545975 888 3195
SGTC_492 tmb-8 126 µM -0.924040508837551 0.148892832976329 no 2869 0.177732612655541 900 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1703 st026983 48.3 µM -0.924539264918287 0.148762077328051 no 2870 0.177602809031007 897 1104023
SGTC_2063 5246145 200 µM -0.925524395357504 0.14850403762875 no 2871 0.177346600016165 923 711240
SGTC_937 3122-0005 46.7 µM -0.92593494834841 0.148396588025285 no 2872 0.177239893869635 882 759535
SGTC_800 3448-7362 155 µM -0.926293009490349 0.148302919007536 no 2873 0.17714686390195 909 15991913
SGTC_877 0771-0151 33.1 µM -0.928958665775575 0.147606825081435 no 2874 0.176455253948707 920 6166523
SGTC_1187 1391-0724 117 µM -0.933916270593644 0.146318053711312 no 2875 0.175173542598716 922 6997986
SGTC_3247 9135149 49.47 µM -0.934407060415057 0.146190881017675 no 2876 0.175046978558008 914 8934436 YOR116C RPO31
SGTC_3289 9119912 71.43 µM -0.936627125792505 0.145616548759566 no 2877 0.174475196872889 926 17014829
SGTC_549 1661-1316 519 µM -0.941074284277045 0.144470634950852 no 2878 0.173333396381003 916 2857282
SGTC_611 3453-1652 23.7 µM -0.942979367124836 0.143981610093545 no 2879 0.172845728327646 911 1560575
SGTC_986 1493-0483 84 µM -0.943050714063541 0.143963317419959 no 2880 0.17282748175575 913 40079
SGTC_185 k048-0037 25.491 µM -0.943067832092089 0.143958928754122 no 2881 0.17282310410037 896 6827589
SGTC_3113 9123498 49.47 µM -0.944116494916764 0.143690247988295 no 2882 0.172555060539594 937 8897275
SGTC_520 3584-0023 682 µM -0.944136894754863 0.143685024647742 no 2883 0.172549848867085 905 1340790
SGTC_2452 5863136 48.41 µM -0.945585711497213 0.143314385503965 no 2884 0.172179967442989 919 2184096
SGTC_1179 1021-1431 9.29 µM -0.946587069117598 0.14305859388383 no 2885 0.171924617810951 940 2840958
SGTC_691 1548-0686 185 µM -0.947918220139704 0.142719036081042 no 2886 0.171585544293354 904 46495133
SGTC_3236 9132701 49.47 µM -0.949222565047129 0.142386845075983 no 2887 0.171253713635557 936 24282524
SGTC_2007 4011539 71.82 µM -0.950198330891031 0.142138678971117 no 2888 0.171005743296358 907 45595301
SGTC_547 1120-0019 610 nM -0.950783295669218 0.141990045563699 no 2889 0.170857196994073 874 3676939
SGTC_2781 5567276 71.43 µM -0.952438799125107 0.141569969951164 no 2890 0.170437245124796 931 2853274
SGTC_2776 terbinafine 19.92 µM -0.953799358232967 0.141225365943402 no 2891 0.170092607165175 889 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_277 nystatin 15.5 µM -0.953917699605536 0.141195419207979 no 2892 0.170062651697864 945 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_446 go6976 132 µM -0.956175048529068 0.140625012745643 no 2893 0.169491901848859 933 3501 A protein kinase C inhibitor.
SGTC_3099 9120367 49.47 µM -0.95715327440733 0.140378312571531 no 2894 0.169244948633488 919 24824940
SGTC_2600 tangeritin 87.95 µM -0.960063839092808 0.139646031926707 no 2895 0.168511543212661 921 68077 A bioactive flavone.
SGTC_1614 st002383 48.6 µM -0.966944960311349 0.137925127222316 no 2896 0.166785774524119 893 1947235
SGTC_1244 0416-0015 52.5 µM -0.968623171899689 0.137507625771508 no 2897 0.166366618830514 919 96201
SGTC_2588 indole-3-carbinol 100 µM -0.969901716545959 0.137190132102665 no 2898 0.166047742185668 924 3712 Induces cell cycle arrest.
SGTC_3057 9095946 49.47 µM -0.969921740178826 0.137185163734432 no 2899 0.166042751315357 939 24540043
SGTC_1031 k035-0009 16 µM -0.97054683710873 0.137030123231381 no 2900 0.165886995280503 938 5180959
SGTC_114 0364-0001 490.298 µM -0.972585029850796 0.136525429586833 no 2901 0.165379792919048 928 4003655
SGTC_55 0767-0285 6.563 µM -0.972900660542804 0.136447387504663 no 2902 0.165301338329597 921 3116166
SGTC_38 0929-0051 58.268 µM -0.974232331834513 0.136118457685033 no 2903 0.1649705973122 926 1379719
SGTC_1995 st072814 61.1 µM -0.974693118447166 0.136004767457412 no 2904 0.164856253738364 930 5769371
SGTC_2880 9042983 58.44 µM -0.97827383269907 0.135123510570759 no 2905 0.163969454140627 935 6464714
SGTC_306 1672-3436 11.6 µM -0.979195248756398 0.134897373826227 no 2906 0.163741757892847 919 6797378
SGTC_2821 7996764 71.43 µM -0.982591507008926 0.134066096531953 no 2907 0.16290426302993 889 2987135
SGTC_788 1182-0090 188 µM -0.984019968265746 0.133717516147778 no 2908 0.162552847462174 919 5715185
SGTC_2715 st079500 56.4 µM -0.984590092392906 0.133578565681764 no 2909 0.162412729118979 914 28246688
SGTC_2871 9038510 12.99 µM -0.984808062072118 0.133525468428951 no 2910 0.162359179895425 916 4945164
SGTC_622 1348-1566 26.3 µM -0.984991391864889 0.133480820666739 no 2911 0.16231414964895 918 7340407
SGTC_2654 protoveratrine a 100 µM -0.985259169880981 0.133415625011243 no 2912 0.162248391480632 934 5702278 A heart drug and vasodilator.
SGTC_2237 6667747 47.222 µM -0.985946131126875 0.13324847140646 no 2913 0.162079773943917 948 729940 YDL015C TSC13
SGTC_1029 k015-0030 64.7 µM -0.987341451370017 0.132909401368527 no 2914 0.161737638151494 915 2208316
SGTC_2971 9092186 9.93 µM -0.990631832643633 0.13211217538352 no 2915 0.160932694003562 919 25236400
SGTC_2016 5121758 140 µM -0.991669260644134 0.131861502203688 no 2916 0.16067944540342 917 2795203
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.991717098237508 0.131849951150301 no 2917 0.160667773954592 941 364106
SGTC_653 0203-0016 55.2 µM -0.992519614866663 0.131656276405983 no 2918 0.160472057955122 939 295302
SGTC_2926 9010726 65.15 µM -0.995070060210971 0.131042070425422 no 2919 0.159851095487426 958 2994293
SGTC_2282 7944268 200 µM -0.995710516574844 0.130888145260065 no 2920 0.159695409427327 943 2970414
SGTC_860 0443-0016 25.1 µM -0.995846505409973 0.130855478241394 no 2921 0.159662365201757 918 5337942
SGTC_2507 purpurin 79.67 µM -0.996527565921066 0.130691959760822 no 2922 0.159496940135559 934 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_11 0438-0307 1.3 µM -0.997602036468591 0.130434273253046 no 2923 0.159236186597406 944 4011476
SGTC_2006 4011487 200 µM -0.998647696819896 0.130183833806237 no 2924 0.158982692960471 926 45595294
SGTC_3182 9108849 49.47 µM -0.999919536809641 0.129879672247074 no 2925 0.158674724451224 919 17133045
SGTC_2862 9027634 71.43 µM -1.00053178121704 0.129733429071275 no 2926 0.158526612658687 916 5012562
SGTC_584 0986-0246 15.4 µM -1.00085542401348 0.129656168535435 no 2927 0.158448354894201 953 53315 YDR232W HEM1
SGTC_2931 9014674 55.67 µM -1.00131470373101 0.129546583243705 no 2928 0.158337343233729 942 2996810
SGTC_2834 9001755 58.44 µM -1.00272195396805 0.129211209384564 no 2929 0.157997517141185 939 2989575
SGTC_766 1391-0721 126 µM -1.00309458994526 0.129122504186648 no 2930 0.157907612373205 962 1020919 YIL115C NUP159
SGTC_750 4073-0104 132 µM -1.00422210796937 0.128854358115369 no 2931 0.157635784109454 888 22330957
SGTC_2477 5967686 25.23 µM -1.0060288521779 0.128425484468979 no 2932 0.157200845637395 945 776118
SGTC_270 tamoxifen 5.46 µM -1.00807023073208 0.127942108280818 no 2933 0.156710373878962 962 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_149 3970-0822 46.1 µM -1.00811868671893 0.127930649810967 no 2934 0.156698743853612 927 3114250 YBL034C STU1
SGTC_217 ketoconazole 989 nM -1.00839832542535 0.127864537100172 no 2935 0.156631638267231 894 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1437 4092-1038 11.6 µM -1.01213219587182 0.126984042968738 no 2936 0.1557374251274 930 3977136
SGTC_1525 8-methoxypsoralen 92.5 µM -1.01312167475784 0.126751420284997 no 2937 0.155501023247062 966 4114 Related to psoralen; DNA damaging agent.
SGTC_1210 3013-0140 750 nM -1.01388026607198 0.126573279445087 no 2938 0.155319944403127 931 905973
SGTC_3029 9088683 49.47 µM -1.01389010110504 0.12657097101905 no 2939 0.155317597654757 931 25236615
SGTC_1270 0831-1170 17.3 µM -1.01400946535242 0.1265429568229 no 2940 0.155289117882049 921 6764716
SGTC_42 0133-0086 60.653 µM -1.01672723702412 0.125906277776762 no 2941 0.154641602456057 942 162923 Model of phenazepam hydroxylation.
SGTC_311 1315-0136 58 µM -1.01678255466367 0.125893342023873 no 2942 0.154628441454297 945 6759207
SGTC_994 3910-0338 138 µM -1.01772745662003 0.125672524559069 no 2943 0.154403747613718 933 3479481
SGTC_2740 felodipine 17.08 µM -1.0198494760396 0.125177607609817 no 2944 0.153899927153427 918 3333 L-type calcium channel blocker
SGTC_1956 st077085 54 µM -1.0199106995844 0.125163348718513 no 2945 0.153885407319027 935 24208685
SGTC_144 4161-2749 112.381 µM -1.02019553781334 0.125097025145034 no 2946 0.153817866733395 922 797501 YMR168C CEP3
SGTC_776 4476-4378 112 µM -1.02056757492992 0.125010434591101 no 2947 0.15372967918029 965 2892008
SGTC_2725 haloperidol 53.21 µM -1.02092252699614 0.124927859567786 no 2948 0.153645572668499 924 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_774 k060-0086 136 µM -1.0242273373633 0.124160866842968 no 2949 0.15286395468058 953 5911235
SGTC_1801 st050089 28.441 µM -1.02440668148254 0.12411933843459 no 2950 0.152821613708975 928 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2121 5257820 149.641 µM -1.02460181195905 0.12407416562264 no 2951 0.15277555460521 932 791256
SGTC_450 aminopyrene 156 nM -1.02766403174887 0.123366766521113 no 2952 0.152053946317195 928 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3066 9117245 49.47 µM -1.02795877967585 0.123298826592394 no 2953 0.151984608959682 922 17176980
SGTC_2515 chrysin 20.77 µM -1.02833120675044 0.123213018976218 no 2954 0.151897028172513 904 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_980 1473-0395 201 µM -1.02874229396643 0.123118352619843 no 2955 0.151800394917177 934 768876
SGTC_3340 9146634 11.102 µM -1.02949385973754 0.122945411698769 no 2956 0.151623831840887 908 4907387
SGTC_1415 3966-0071 78.1 µM -1.03156100250568 0.122470625345367 no 2957 0.151138908551509 932 2893185
SGTC_1466 k213-0079 57.5 µM -1.03182073086882 0.122411061415426 no 2958 0.151078052895053 958 3657981
SGTC_1959 st077091 55.8 µM -1.03214426392959 0.12233689348933 no 2959 0.151002270285913 920 821356 YKL052C ASK1
SGTC_1665 st014639 11.4 µM -1.032818208702 0.122182497173605 no 2960 0.150844490407999 924 981133 YIL048W NEO1
SGTC_592 k241-0073 46.5 µM -1.03344790007806 0.122038362694244 no 2961 0.150697170077653 937 4230158
SGTC_606 k015-0008 38.6 µM -1.0335856128505 0.122006856570256 no 2962 0.150664964064439 969 1970475
SGTC_2461 5755302 26.15 µM -1.03567401058032 0.12152977003347 no 2963 0.150177125534197 972 2788904
SGTC_1496 4469-0713 57.4 µM -1.0356745333128 0.121529650781606 no 2964 0.150177003558637 970 746691
SGTC_3269 9137823 49.47 µM -1.03828334940612 0.120935521297904 no 2965 0.149569079105791 892 17682936
SGTC_485 niflumic acid 177 µM -1.04413928261533 0.119609346973544 no 2966 0.14821047679891 954 4488 A COX2 inhibitor.
SGTC_992 3909-8734 162 µM -1.0444142980306 0.119547318291175 no 2967 0.148146875645134 954 4288319
SGTC_19 0279-0214 38.434 µM -1.04615656709869 0.119154883343811 no 2968 0.147744375979748 946 3566274 YBR002C RER2
SGTC_2674 ligustilide 100 µM -1.04732463757266 0.118892292696951 no 2969 0.147474938325007 943 5319022 A signalling regulator.
SGTC_640 3381-0960 37.1 µM -1.04738080882774 0.118879675302334 no 2970 0.147461989659231 942 1745025
SGTC_176 1486-1328 72.834 µM -1.0476592254118 0.118817150302278 no 2971 0.147397819976351 929 22310231
SGTC_1846 st056244 14.8 µM -1.04880293286318 0.118560547569918 no 2972 0.147134413680977 943 5393182
SGTC_2013 4024628 200 µM -1.05103572195421 0.118060727070621 no 2973 0.146621091856084 968 5230760
SGTC_1777 st045864 34.765 µM -1.05311617226735 0.11759635132789 no 2974 0.146143875849304 966 4691462
SGTC_2943 9068529 45.32 µM -1.05422522679279 0.117349329141638 no 2975 0.145889906483321 939 3270634
SGTC_3040 9091894 49.47 µM -1.05942497584246 0.116196078193485 no 2976 0.144703140061706 906 25236966
SGTC_2148 5546263 113.568 µM -1.05958107599818 0.116161581575526 no 2977 0.144667613310739 964 792097
SGTC_2194 5927483 104.545 µM -1.05960863955767 0.116155491051755 no 2978 0.144661340745329 924 760979
SGTC_778 3456-2434 196 µM -1.05982789307566 0.116107052232075 no 2979 0.144611452333808 864 5539063
SGTC_847 0342-0274 5.54 µM -1.05993805268585 0.116082720513632 no 2980 0.144586391259333 956 18097
SGTC_1802 st050112 57.9 µM -1.0602293334523 0.116018400745229 no 2981 0.144520139608402 944 4662563
SGTC_2497 7-hydroxyflavone 100 µM -1.06116118002395 0.115812803049993 no 2982 0.144308329017553 944 5281894
SGTC_1112 tnp00069 1.16933 µM -1.06174015502897 0.115685191463208 no 2983 0.144176832283373 941 145826
SGTC_16 erodoxin 22.806 µM -1.06184970377783 0.115661057120362 no 2984 0.144151960676263 946 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_280 3448-3607 3.04 µM -1.06334398981557 0.115332212697857 no 2985 0.143812991474018 922 626179
SGTC_2856 9022925 19.48 µM -1.06420972744176 0.115141995926935 no 2986 0.143616850675912 950 4944862
SGTC_1003 4049-0218 100 µM -1.06831223264961 0.11424364120436 no 2987 0.14268984617916 941 295161
SGTC_1848 st056003 16.4 µM -1.07051101155692 0.113764218644925 no 2988 0.142194677569518 913 146492
SGTC_841 0251-0215 91.2 µM -1.07079894735146 0.113701543361532 no 2989 0.142129920171805 949 3888614
SGTC_821 1114-0266 29.2 µM -1.07402066359417 0.11300194701162 no 2990 0.1414067101783 934 3123235
SGTC_512 prima-1 270 µM -1.075201708849 0.112746253926278 no 2991 0.141142215267693 944 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_465 cgp-37157 41 µM -1.07559624127595 0.11266093085027 no 2992 0.141053934584126 917 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2774 tamoxifen 10.92 µM -1.07898861751402 0.111929185163814 no 2993 0.140296400929783 938 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1350 1495-0454 146 µM -1.07974372987038 0.111766768650143 no 2994 0.140128157426078 941 1069057
SGTC_530 4358-1714 28 µM -1.0827930520677 0.111112607357206 no 2995 0.139450145091623 920 1564641
SGTC_1111 tnp00062 510.699 nM -1.08303046073261 0.111061792121757 no 2996 0.139397451412277 938 676306
SGTC_1459 k035-0031 35.7 µM -1.08325522998385 0.111013697581351 no 2997 0.139347575579049 914 3877128 YMR208W ERG12
SGTC_13 0199-0087 65 µM -1.08413663996929 0.110825243626237 no 2998 0.139152109684044 950 4589825
SGTC_3043 9092303 49.47 µM -1.08733443704619 0.110143448309513 no 2999 0.13844451733375 944 25236084
SGTC_2759 disulfiram 3.38 µM -1.08957597679483 0.109667331618349 no 3000 0.137949985050666 914 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_927 2425-1185 123 µM -1.09040245923251 0.109492155094422 no 3001 0.137767949519817 965 730375
SGTC_939 1165-0479 45.3 µM -1.09434102192098 0.10866012019668 no 3002 0.13690272008202 934 1377347
SGTC_1234 0326-0494 15.5 µM -1.09479365050737 0.108564792963085 no 3003 0.136803524395238 953 1547813
SGTC_1304 1165-0502 251 µM -1.09733043499644 0.108031638975101 no 3004 0.136248485535502 941 767425
SGTC_2140 5586273 200 µM -1.09798907843227 0.107893521198799 no 3005 0.136104629172979 951 854421
SGTC_54 0159-0055 9 µM -1.10458262969783 0.106517855671121 no 3006 0.134670240600459 951 3319099
SGTC_921 1561-0023 372 µM -1.10489560918653 0.106452872500612 no 3007 0.134602412615739 928 24050882
SGTC_2264 7948757 110.76 µM -1.10709932690524 0.105996130139901 no 3008 0.134125493266436 953 2971411
SGTC_1228 0124-0032 52.5 µM -1.10895501209073 0.105612620611183 no 3009 0.133724795006781 947 X1228
SGTC_2082 5219693 150 µM -1.11324049895627 0.104730786791259 no 3010 0.132802576690965 941 2834649
SGTC_2365 9042475 200 µM -1.11626996946663 0.104110631411025 no 3011 0.132153296028027 942 6464479
SGTC_596 1155-0152 116 µM -1.11791778140215 0.103774431911878 no 3012 0.131801054986349 947 280313
SGTC_2339 9000433 200 µM -1.11838747213119 0.103678746326619 no 3013 0.131700771275698 953 2988954
SGTC_1678 st019265 80.2 µM -1.11899368487001 0.103555343070278 no 3014 0.131571416588561 945 5367020
SGTC_699 0375-0592 111 µM -1.1193541790005 0.103482009902852 no 3015 0.131494535340515 914 762578
SGTC_2643 anethole 100 µM -1.12311826382818 0.102718555104956 no 3016 0.130693635157743 984 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_382 3229-0966 23.2 µM -1.1232407181752 0.102693787098543 no 3017 0.130667636792375 970 5722370
SGTC_229 benomyl 22.8748 µM -1.1255128164518 0.102235012455451 no 3018 0.13018589464804 949 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1392 3455-1037 33.9 µM -1.12975217201916 0.101383004869027 no 3019 0.129290333326163 934 981132
SGTC_2581 avocatin a 64 µM -1.13002239241486 0.101328873011024 no 3020 0.129233394541426 977 6710728 A skin care supplement.
SGTC_1816 st051957 91.6 µM -1.13100835931419 0.101131537935087 no 3021 0.129025786527368 988 674121
SGTC_422 cantharidin 155 µM -1.13148081773854 0.101037077673242 no 3022 0.128926386333692 971 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1785 bathophenanthroline 24 µM -1.13266216680565 0.100801167909724 no 3023 0.128678075606781 913 72812 An iron chelator.
SGTC_1426 4048-4480 71.7 µM -1.13507361233599 0.100320861040791 no 3024 0.128172238349158 963 14224343
SGTC_1409 3909-8004 61.9 µM -1.13544869571881 0.100246303044272 no 3025 0.128093683202764 960 2119279
SGTC_2508 celastrol 40.54 µM -1.13716149988332 0.0999063507767766 no 3026 0.127735389147229 914 122724 Celastrol is a natural product and antioxidant.
SGTC_3170 9103054 49.47 µM -1.13760210092618 0.0998190379050861 no 3027 0.127643334481757 945 16432970
SGTC_1644 st010134 20.9 µM -1.13781159468921 0.0997775425765617 no 3028 0.127599581183455 965 3818134
SGTC_1910 st062352 60.4 µM -1.13805478393491 0.0997293888454713 no 3029 0.12754880357774 960 2245730
SGTC_3088 9117578 49.47 µM -1.14064919824632 0.099216727101231 no 3030 0.12700796755 1006 678341
SGTC_3017 9080681 49.47 µM -1.14070408257405 0.0992059026957217 no 3031 0.126996543535142 983 16451914
SGTC_24 0417-1663 219 µM -1.14487049583969 0.0983867127534092 no 3032 0.126131403736817 996 4329390
SGTC_2663 amphotericin b 100 µM -1.14519023090638 0.0983240524950065 no 3033 0.126065182120647 964 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_904 1141-0088 396 µM -1.14800766661511 0.09777316702561 no 3034 0.125482699456817 991 1378119
SGTC_2400 5203494 178.7 µM -1.15572649100249 0.0962755234512649 no 3035 0.123896524444359 954 6777674
SGTC_2185 6113692 200 µM -1.15651444417818 0.096123594633271 no 3036 0.123735397444329 972 874150
SGTC_222 nsc-310342 10.666 µM -1.15780720296879 0.0958747139064411 no 3037 0.123471361640165 963 432556
SGTC_685 1278-0033 54.9 µM -1.15999499851183 0.0954546018503728 no 3038 0.123025421214188 958 3590572
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.16035986106251 0.0953846710479073 no 3039 0.122951160924954 974 676296 Flavone; oxidizing agent.
SGTC_1863 st057641 20.1 µM -1.16041447126565 0.0953742075155356 no 3040 0.122940048842618 991 3921635
SGTC_2924 9010168 62.78 µM -1.16530728078177 0.0944401517294613 no 3041 0.121947316513109 980 2993929
SGTC_710 3448-4187 58 µM -1.17113302430759 0.0933368132553544 no 3042 0.120772655677478 958 3946412
SGTC_952 1185-0122 232 µM -1.17558907337233 0.0924993307349039 no 3043 0.119879561983773 962 678600
SGTC_751 0833-0568 350 µM -1.17589971143308 0.0924411564984714 no 3044 0.119817477104281 979 6954252
SGTC_1224 0823-0416 294 µM -1.17638296005431 0.092350710722098 no 3045 0.119720938930372 960 3598164
SGTC_2047 4141938 200 µM -1.17747921821931 0.0921457756753429 no 3046 0.119502143741069 972 3807862
SGTC_237 nikkomycin 200 µM -1.17955646981301 0.0917583769357483 no 3047 0.119088332333755 993 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_136 0097-0015 404.482 µM -1.18237193674211 0.0912352318260294 no 3048 0.118529076645773 972 4861337
SGTC_2682 pyrogallin 40.03 µM -1.18657052916543 0.0904591994939359 no 3049 0.117698533131686 968 822798 An ATP competetive kinase inhibitor.
SGTC_1786 berberine 21.6 µM -1.1873082260082 0.0903233575487495 no 3050 0.117553032287133 934 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2351 9026858 72.31 µM -1.1885251129134 0.0900996071181107 no 3051 0.117313295969009 1001 1409300
SGTC_3186 9110464 49.47 µM -1.18853787587468 0.0900972625615012 no 3052 0.117310783401263 976 17018021
SGTC_1064 honokiol 6.76 µM -1.18894701710879 0.0900221273114207 no 3053 0.117230258410562 992 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3093 9117344 49.47 µM -1.19502492812171 0.088911448654866 no 3054 0.116038645366327 954 24824913
SGTC_2612 dictamnine 15.46 µM -1.19514000417572 0.0888905184870856 no 3055 0.116016167217692 934 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_753 1322-0200 289 µM -1.19574254008528 0.0887809884320098 no 3056 0.115898522546517 975 5403907
SGTC_712 r015-0009 80.6 µM -1.19981340872708 0.0880436106050213 no 3057 0.115105907701489 980 6813872 YLR060W FRS1
SGTC_2442 5158906 48.48 µM -1.2027891059822 0.0875075026632993 no 3058 0.114528970781273 952 1893835
SGTC_1818 st052136 56.3 µM -1.21074508367265 0.0860861057723738 no 3059 0.112996559008343 929 674169
SGTC_1686 st019653 115.5 µM -1.21229243322175 0.0858116775505351 no 3060 0.112700229677406 997 97252
SGTC_466 geldanamycin 89.2 µM -1.21384987443748 0.0855361212934308 no 3061 0.112402528504006 967 5288382 HSP90 inhibitor.
SGTC_2845 9003024 42.97 µM -1.2164252167122 0.0850819235827468 no 3062 0.111911491397808 961 2990173
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.21709117485064 0.0849647671941084 no 3063 0.111784764034214 986 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_398 bronopol 33.3 µM -1.22341757294978 0.0838578420819531 no 3064 0.110586009694607 965 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1014 4130-3005 69.3 µM -1.22344840200792 0.0838524745909942 no 3065 0.11058019071442 990 743608
SGTC_1919 st067113 52.3 µM -1.22574445560264 0.0834534451772576 no 3066 0.110147427612464 987 1268243
SGTC_1989 st071868 50.2 µM -1.22590698089115 0.0834252542080609 no 3067 0.110116840745493 963 16414057
SGTC_615 k087-0205 167 µM -1.22933407654697 0.0828324698023345 no 3068 0.10947328795025 985 9642773
SGTC_741 4582-0002 126 µM -1.23216885612456 0.0823445376679869 no 3069 0.108943007235959 962 2912688
SGTC_2985 9022375 71.43 µM -1.23523676715141 0.0818189201954632 no 3070 0.108371199665508 990 4939335
SGTC_284 0988-0104 32.6 µM -1.23560761410742 0.0817555556201709 no 3071 0.108302226540555 976 4666532
SGTC_946 3434-1334 87.4 µM -1.23864892285035 0.081237298872491 no 3072 0.107737770953318 965 4047976
SGTC_2391 6285546 200 µM -1.23987111884541 0.0810297291486596 no 3073 0.107511533909482 980 846083
SGTC_863 0466-0191 129 µM -1.24220868521697 0.080633847562016 no 3074 0.107079788007396 982 765160 YPR165W RHO1
SGTC_2426 5582046 32.21 µM -1.24672601854591 0.0798729504593237 no 3075 0.106248987613902 978 2251934
SGTC_1531 st059297 52.4 µM -1.24786728938918 0.0796815774116306 no 3076 0.106039830707057 977 7566702
SGTC_2058 5236698 133 µM -1.24794767551576 0.0796681110192397 no 3077 0.106025109832405 970 766665
SGTC_1449 4112-4002 201 µM -1.24871116404006 0.0795402962136396 no 3078 0.105885368036561 990 2059539
SGTC_1527 coumarin 137 µM -1.25520215656693 0.078459906347717 no 3079 0.104702691437577 1003 323 A hepatotoxic, DNA x-linker.
SGTC_292 k038-0015 474 µM -1.25535877773937 0.0784339757656949 no 3080 0.10467427331908 992 46368540
SGTC_1934 st074720 32.6 µM -1.25636336988392 0.0782678075177785 no 3081 0.104492127989154 966 17250992
SGTC_3002 9075603 71.4286 µM -1.25727292640529 0.0781175893978842 no 3082 0.1043274120022 957 20105405
SGTC_1124 fisetin 1.16336 µM -1.26253480921457 0.0772528506710214 no 3083 0.103378204473129 985 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_362 0310-0100 9.03 µM -1.26276325139163 0.0772154738255687 no 3084 0.103337137537774 987 790235
SGTC_3280 9140961 49.47 µM -1.26277483456858 0.0772135789960002 no 3085 0.103335055551409 1003 4901226
SGTC_1308 1187-1617 41.4 µM -1.26337424129956 0.0771155734834569 no 3086 0.103227358391238 989 2882570
SGTC_2011 4012611 177 µM -1.26382606145882 0.0770417614969661 no 3087 0.103146232430025 993 2049887
SGTC_1182 1222-0449 220 µM -1.26762894468502 0.0764226266339839 no 3088 0.102465245185597 977 658318
SGTC_673 1082-0474 110 µM -1.26975337185617 0.0760784076370998 no 3089 0.102086247373442 977 3098046
SGTC_1771 st048882 4.1505 µM -1.27126520914496 0.075834165759474 no 3090 0.101817157470788 990 4580403
SGTC_3052 9092717 49.47 µM -1.27247430163555 0.075639263357255 no 3091 0.101602324570818 993 25237534
SGTC_3308 9128332 17.569 µM -1.27394262419974 0.0754030871861494 no 3092 0.101341875446245 980 17332805 YDL196W YDL196W
SGTC_385 1494-0393 12.4 µM -1.27550522352471 0.0751523646072247 no 3093 0.101065238236152 994 3090647
SGTC_181 1447-1644 8.07 µM -1.2790490333312 0.0745861084863816 no 3094 0.100439894791814 1011 534600
SGTC_803 4488-1585 147 µM -1.27961753701243 0.074495572674562 no 3095 0.1003398395515 969 747204
SGTC_458 nppb 133 µM -1.28218452642202 0.0740878167032702 no 3096 0.0998889614710125 1002 4549 A chloride channel blocker.
SGTC_897 1000-0139 31.4 µM -1.28228129284314 0.0740724791591236 no 3097 0.0998719939515833 991 6151020
SGTC_3216 9129716 49.47 µM -1.28498612916447 0.0736447415684472 no 3098 0.0993985655964753 971 8056934
SGTC_187 1488-2104 32.728 µM -1.28504308306373 0.0736357553312757 no 3099 0.0993886146033932 995 2852859
SGTC_1960 st011366 51.8 µM -1.2874610847698 0.0732550136631704 no 3100 0.0989668125436376 981 3972846
SGTC_717 1532-0246 73.2 µM -1.28785890329694 0.0731925171811266 no 3101 0.0988975417561487 976 9561992
SGTC_3187 9109394 49.47 µM -1.29122598117065 0.0726651888450762 no 3102 0.0983126642277235 983 17098090
SGTC_288 1315-0019 35.1 µM -1.29523009337908 0.0720418856129054 no 3103 0.0976204332367263 974 6811474
SGTC_2814 7977482 42.97 µM -1.29951089693388 0.0713800533263249 no 3104 0.0968843281385411 991 6456762
SGTC_1173 0443-0020 122 µM -1.30096781872818 0.071155873966604 no 3105 0.0966347351705547 1008 5331295
SGTC_161 4065-0411 162.148 µM -1.301650154949 0.0710510676431115 no 3106 0.0965180030818 994 1906281 YLR208W SEC13
SGTC_1842 st055362 61.2 µM -1.30763135921984 0.0701374273447746 no 3107 0.0954991875679452 979 676032
SGTC_2908 7930301 100 µM -1.30862268494826 0.0699868773956144 no 3108 0.0953310963980961 989 2223178
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.30969131232242 0.069824866465965 no 3109 0.0951501418736991 997 66535 A nucleotide analog.
SGTC_3192 9110362 49.47 µM -1.31130701200233 0.0695804640953012 no 3110 0.0948770301657866 1018 16649480
SGTC_724 3910-0327 137 µM -1.31400156784211 0.0691743321167544 no 3111 0.0944228383076043 1001 2885483
SGTC_77 0828-0286 12.516 µM -1.31410763109242 0.0691583833707438 no 3112 0.0944049932365429 980 745345
SGTC_252 miconazole 1.30953 nM -1.31553573616903 0.0689439148246349 no 3113 0.0941649576421999 966 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1226 3909-7979 35.4 µM -1.31676582494423 0.0687595950612046 no 3114 0.0939585657615078 991 6615510
SGTC_2173 5763948 167 µM -1.31749303859481 0.0686508062914292 no 3115 0.093836706494828 1000 2867177
SGTC_527 4476-4215 268 µM -1.31776532222693 0.0686101077285669 no 3116 0.0937911099278243 977 4418754
SGTC_1062 mesoridazine 14.2 µM -1.31902091127622 0.0684226740387489 no 3117 0.0935810608066814 975 4078 A neuroleptic.
SGTC_950 1165-0508 94.1 µM -1.32440017743727 0.0676241289269437 no 3118 0.0926850878516762 997 6148369
SGTC_619 1652-1634 108 µM -1.32515370032322 0.0675128467497016 no 3119 0.0925600890805555 1015 5400454
SGTC_3328 9140624 29.0385 µM -1.3262793610573 0.0673468699789685 no 3120 0.0923735902798869 1008 4904392
SGTC_1364 1653-0028 37.6 µM -1.32733950764429 0.0671908417380345 no 3121 0.0921982002331879 983 5718652
SGTC_1862 st057513 3.81 µM -1.32760000146473 0.0671525460826038 no 3122 0.0921551420355832 997 5393163
SGTC_281 1672-3440 14.9 µM -1.33726465276923 0.065743624195042 no 3123 0.0905681323174381 1006 6833000
SGTC_1884 5633444 25 µM -1.33923690302455 0.0654589432057886 no 3124 0.090246781166256 987 5724239
SGTC_1176 0848-0131 83.3 µM -1.33926137425527 0.0654554169635024 no 3125 0.0902427992407 999 6769040
SGTC_257 daunorubicin 18.5 µM -1.34095287620487 0.0652120326763945 no 3126 0.0899678764907483 965 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_907 3448-6986 75.5 µM -1.34588743049163 0.0645060282449819 no 3127 0.0891694115501498 999 590582
SGTC_833 3852-0053 558 µM -1.34650341581883 0.0644183154874148 no 3128 0.089070109763361 1029 3123681
SGTC_1386 3228-0095 33.8 µM -1.3519263833242 0.0636501103281486 no 3129 0.0881994332559009 999 870181
SGTC_3281 9140613 49.47 µM -1.35361852878379 0.0634118695787719 no 3130 0.0879290562204794 972 16013766
SGTC_1145 3546-0597 10.2 µM -1.35554026065914 0.0631421472557688 no 3131 0.0876227451965496 999 875334
SGTC_2270 7924575 90.91 µM -1.35809228136763 0.0627853435511728 no 3132 0.0872172020556044 986 1262135
SGTC_319 1348-1596 45.5 µM -1.36359264802532 0.0620216687774577 no 3133 0.0863479036396745 1001 5380505
SGTC_1680 diphenhydramine 100 µM -1.36716834811152 0.0615291164460822 no 3134 0.0857862719721133 979 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_859 0439-0102 54.6 µM -1.3679402882908 0.0614231837879628 no 3135 0.0856653837734083 991 610143
SGTC_1505 k297-0037 20.6 µM -1.36841517200561 0.0613580867333082 no 3136 0.0855910789188015 992 4089396
SGTC_565 1418-0001 44.5 µM -1.36975746672894 0.0611743764453287 no 3137 0.0853813116303736 1009 2862145
SGTC_767 0929-0023 86 µM -1.37099564410034 0.0610052973416963 no 3138 0.0851881569565776 1004 1204563
SGTC_2105 5350118 200 µM -1.37597710497269 0.0603287436400065 no 3139 0.0844143608213612 1001 2133313
SGTC_1384 3089-0840 101 µM -1.37613267739052 0.060307709623494 no 3140 0.0843902801555832 1000 1069836
SGTC_1734 st037168 69.4 µM -1.37897272016322 0.0599247324046323 no 3141 0.083951582509991 1010 708907
SGTC_593 1203-0218 61.7 µM -1.38326891796546 0.0593490173288536 no 3142 0.083291212377414 1019 3666956
SGTC_1377 2944-0135 198 µM -1.38452162044493 0.0591819671642629 no 3143 0.0830993963065347 973 1894137
SGTC_1258 0671-0043 57.1 µM -1.39211279223463 0.058177545875768 no 3144 0.0819441225594199 1021 4298767
SGTC_2319 6033012 152.6 µM -1.39215884470206 0.0581714936014155 no 3145 0.0819371511198518 1006 847246
SGTC_1941 st076221 61.8 µM -1.39625099257781 0.0576356704410988 no 3146 0.0813194629738775 969 2828568
SGTC_1463 k081-0032 34.1 µM -1.39946209428577 0.0572179349857239 no 3147 0.0808372288226108 939 977755
SGTC_2259 7964009 200 µM -1.39964488321037 0.0571942276603291 no 3148 0.080809843189035 992 313134
SGTC_3231 9132313 49.47 µM -1.4008674974414 0.0570358559933349 no 3149 0.0806268498991521 1004 4905967
SGTC_397 arbidol 50 µM -1.40304597935458 0.0567545216073973 no 3150 0.0803015642058033 1004 131410 A RNA synthesis inhibitor.
SGTC_2441 5730946 39.09 µM -1.41221158907674 0.0555828092846464 no 3151 0.0789438345808748 990 1774275
SGTC_797 k781-0471 270 µM -1.41238456563814 0.0555608813095706 no 3152 0.0789183792638781 983 23738129
SGTC_740 k014-0057 261 µM -1.41431491412461 0.0553166370324235 no 3153 0.0786347299381621 1012 4012779
SGTC_1154 4088-0362 150 µM -1.41561527148172 0.0551525831829284 no 3154 0.0784440887955688 1016 6618304
SGTC_3130 9127414 49.47 µM -1.41881639286108 0.0547503653648336 no 3155 0.0779762760973337 1019 1494646
SGTC_2627 acetyl isogambogic acid 100 µM -1.41997202194319 0.0546057326556827 no 3156 0.0778079132089459 1008 6857789 A caspase activator and apoptosis inducer.
SGTC_2327 6189656 200 µM -1.42109472328796 0.0544655105101369 no 3157 0.0776446119083896 1012 5349088
SGTC_2610 ononetin 44.17 µM -1.42119845106621 0.0544525695962974 no 3158 0.077629537438053 1020 259632
SGTC_984 1492-0255 2.91 µM -1.42166373020069 0.0543945520244509 no 3159 0.0775619470477285 1019 1585198
SGTC_851 0394-0702 453 µM -1.42570986370072 0.0538920822660033 no 3160 0.0769760540752342 1017 762646
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.42751184429422 0.0536694890917527 no 3161 0.0767162068115129 1017 688662
SGTC_756 0508-1999 28.3 µM -1.43121496484311 0.0532143402196149 no 3162 0.0761843079685804 1009 6753853
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.43508056317442 0.052742491088096 no 3163 0.075632070791367 1014 229346 A bile salt which induces apoptosis.
SGTC_1554 st069299 38.7 µM -1.43658316566236 0.0525599763219059 no 3164 0.0754182348972511 1002 24207999
SGTC_228 caffeine 993.056 µM -1.4377051177656 0.0524240247143091 no 3165 0.0752588701987324 1009 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1701 st028638 40.4 µM -1.43805502436493 0.0523816822318029 no 3166 0.0752092212020395 1022 3490878
SGTC_1123 mangostin 811.285 nM -1.438107973554 0.0523752771732877 no 3167 0.0752017103040961 974 5281650 An antioxidant.
SGTC_2679 rapamycin 1 nM -1.43882162033741 0.0522890107382989 no 3168 0.0751005345501853 955 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1603 st002045 67.8 µM -1.43927332072495 0.052234467015593 no 3169 0.0750365493528294 1022 5887985
SGTC_2709 st078560 56 µM -1.44097254936873 0.0520296863635844 no 3170 0.0747962190473214 1021 17250903
SGTC_1248 0469-0687 58.6 µM -1.44273930847268 0.0518174442162599 no 3171 0.0745469608042644 1007 4017482
SGTC_1889 st059080 5.18 µM -1.44677653013664 0.0513350322626716 no 3172 0.073979761068153 1018 176925 Isolated from Daphnopsis sellowiana.
SGTC_1832 st054113 55 µM -1.45408634410395 0.0504706709047367 no 3173 0.0729611845606956 1011 1251267
SGTC_478 N-arachidonylglycine 10 µM -1.45502049278662 0.0503610514586656 no 3174 0.0728317941467507 1030 5283389
SGTC_3248 9135562 49.47 µM -1.455938694578 0.0502534883127493 no 3175 0.0727047838366505 1013 17650701
SGTC_93 0109-0045 59.227 µM -1.45896120533369 0.0499007079473007 no 3176 0.0722878928113566 1034 88733
SGTC_10 0279-0212 42.575 µM -1.46472411057987 0.0492335503742645 no 3177 0.0714981020341693 1034 39851 YBR002C RER2
SGTC_322 k048-0136 19.3 µM -1.46546282082583 0.0491485491294918 no 3178 0.0713973444156595 1027 6823282
SGTC_1475 4092-1048 11.7 µM -1.46560472175907 0.0491322344286146 no 3179 0.0713780020846378 1030 2881759
SGTC_2097 5376186 200 µM -1.46740900595144 0.0489251683503716 no 3180 0.0711324130237822 1020 742755
SGTC_1429 4049-0205 9.46 µM -1.46751706187559 0.0489127896311495 no 3181 0.0711177256749625 1009 22774478
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.46766614436182 0.0488957150808452 no 3182 0.0710974656716426 1027 15053
SGTC_3294 9122953 26.2835 µM -1.47207749647864 0.0483926309789923 no 3183 0.0704999757910255 1022 16459826
SGTC_2887 9044784 58.44 µM -1.4759583682622 0.0479534753553268 no 3184 0.0699775343702916 1007 6465546
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.47931959111178 0.047575705802313 no 3185 0.0695274596217638 1023 641818 YHR062C RPP1
SGTC_676 falcarinol 140 µM -1.47941600218011 0.0475649053832423 no 3186 0.0695145829415502 1009 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1721 st082152 9.2685 µM -1.47962852289314 0.0475411047546148 no 3187 0.0694862051212969 1006 5296051
SGTC_78 0336-0123 156.75 µM -1.48234754120332 0.0472374374208256 no 3188 0.0691239222795174 1002 6765896
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.48400510807855 0.0470530799245734 no 3189 0.0689037827286335 1014 165506
SGTC_2205 7238770 200 µM -1.48679105647033 0.0467445219145448 no 3190 0.068535002177199 1016 279867
SGTC_902 1120-0002 2.07 µM -1.49607107206366 0.0457284063519018 no 3191 0.0673175676750608 966 3280475
SGTC_2718 lomofungin 53.02 µM -1.49643917949229 0.0456884694308545 no 3192 0.0672696230550877 1021 5351222 A RNA synthesis inhibitor.
SGTC_1358 1509-0022 2.48 µM -1.49684616732897 0.0456443469152222 no 3193 0.0672166451400608 1015 3258434
SGTC_124 0136-0217 7.121 µM -1.5005194192405 0.0452476689420916 no 3194 0.0667399535414344 1011 3976905
SGTC_1256 0570-0116 285 µM -1.50385841943773 0.0448894979485693 no 3195 0.0663089126441734 1027 410638
SGTC_2798 7813637 45.45 µM -1.50764401883801 0.04448618534515 no 3196 0.0658228301396406 1015 956368
SGTC_2179 6298986 200 µM -1.51128543344323 0.0441009937302924 no 3197 0.065357871801414 975 738374
SGTC_1950 st077106 7.18 µM -1.51484041803613 0.0437275433010576 no 3198 0.0649064110474433 1003 13831864
SGTC_1561 5-methoxyflavone 52.9 µM -1.52006367416063 0.0431834741266715 no 3199 0.0642474866158763 1003 94525
SGTC_2964 9083345 53.42 µM -1.5219736160686 0.0429858995119642 no 3200 0.0640078458692205 998 17741579
SGTC_2762 leflunomide 42.06 µM -1.52561284731829 0.0426114598943111 no 3201 0.0635531553395386 1033 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1396 3511-0007 98.6 µM -1.52790750011781 0.0423767223373342 no 3202 0.063267752895026 1014 X1396
SGTC_1065 prochlorperazine maleate 2.48 µM -1.5281871861612 0.0423481827714226 no 3203 0.0632330346677713 1038 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3189 9110682 49.47 µM -1.53012333574339 0.0421510414160616 no 3204 0.0629931015284992 1040 17122418
SGTC_2235 salicylic acid 500 µM -1.53055106849185 0.0421075894080266 no 3205 0.0629401914372243 1041 338 A COX inhibitor and kinase inhibitor.
SGTC_632 0781-2353 4.65 µM -1.53461456857891 0.0416965970074865 no 3206 0.062439265971725 1046 6811515 YHR007C ERG11
SGTC_2345 9052315 157.45 µM -1.53554798915462 0.0416026489394285 no 3207 0.0623246393444729 1013 6469265
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.53690480058535 0.0414663927789042 no 3208 0.0621583118849888 1046 688801
SGTC_2642 cholecalciferol 100 µM -1.53762021403551 0.0413946939778541 no 3209 0.0620707510231697 1010 9821465 A vitamin D precursor, similar to steriods.
SGTC_1928 4'-methoxychalcone 40.3 µM -1.53896905301533 0.0412597865187884 no 3210 0.0619059257657016 1022 641818
SGTC_1097 itavastatin 7.23 µM -1.54019910700076 0.0411370705615102 no 3211 0.0617559137611144 1023 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2211 7117706 200 µM -1.54776491130372 0.0403887643113032 no 3212 0.0608394537037178 1016 822771
SGTC_2514 salinomycin 42.74 µM -1.55073810594218 0.0400977383141926 no 3213 0.0604822293044836 1034 23682228 A polyether potassium ionophore.
SGTC_1503 4585-0012 61.3 µM -1.55629037981649 0.039558826264088 no 3214 0.0598195289985117 1030 2922052
SGTC_2135 5326629 150.42 µM -1.56035667151465 0.0391678947441801 no 3215 0.0593378089765527 1026 5020077
SGTC_1231 0242-0792 125 µM -1.57123336532621 0.0381376500404066 no 3216 0.0580642263174052 1029 3707635
SGTC_1300 1094-0077 113 µM -1.57171220369659 0.038092807105151 no 3217 0.0580086553312275 1036 5532636
SGTC_3154 9100113 49.47 µM -1.58105063739144 0.0372268335315253 no 3218 0.0569332300319146 1023 25237525
SGTC_121 0557-0495 61.343 µM -1.58241379575463 0.0371017808100161 no 3219 0.0567775686852557 1041 3104427
SGTC_2464 5717415 7.67 µM -1.58617040790553 0.0367589345069215 no 3220 0.056350329320557 1030 5285744
SGTC_190 3970-0790 3.722 µM -1.58688511365035 0.0366940013323563 no 3221 0.0562693335252514 1030 2832352
SGTC_326 k292-0812 17.5 µM -1.60131728843828 0.0354027485243416 no 3222 0.054653330880738 1018 3579357
SGTC_3115 9123671 49.47 µM -1.60341549105474 0.035218161915136 no 3223 0.0544214765960382 1068 3286988
SGTC_1515 3460-0031 42.1 µM -1.61234796968192 0.0344411537544703 no 3224 0.0534431201138055 1025 2876596
SGTC_108 0509-0257 621.132 µM -1.6148214632982 0.0342285001474358 no 3225 0.0531746818636286 1039 536624
SGTC_477 mead ethanolamide 10 µM -1.6169301047906 0.034048067286216 no 3226 0.0529466845908951 1051 16061185
SGTC_2104 5389443 200 µM -1.62074477114295 0.0337236403051316 no 3227 0.0525361937538308 1050 2244536
SGTC_439 amiodarone 34.4 µM -1.62271972960021 0.0335566774196213 no 3228 0.0523246659122353 1023 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1963 st076565 50.3 µM -1.6398126017689 0.0321398917322376 no 3229 0.0505220685934152 1057 4914280
SGTC_672 1441-0018 53.7 µM -1.64184824457726 0.0319745022027843 no 3230 0.0503107289667435 1025 251141
SGTC_1118 chelidonine 707.474 nM -1.64641303110229 0.0316061820021389 no 3231 0.0498393760071017 1044 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2108 5365811 200 µM -1.66636789724124 0.0300370135454116 no 3232 0.047820080400905 1027 780283
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.67164654876362 0.029632900363116 no 3233 0.0472970200059918 1042 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_258 haloperidol 50.781 µM -1.67197885959343 0.0296076116242319 no 3234 0.0472642454205348 1044 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1898 st060199 18.6 µM -1.67353877484275 0.0294891418769097 no 3235 0.0471106399569608 1022 688866
SGTC_468 gf-109203x 121 µM -1.67731591640342 0.0292039113720916 no 3236 0.0467403608933101 1067 2396 A protein kinase C inhibitor.
SGTC_3078 9116413 49.47 µM -1.6785945852574 0.0291078735414089 no 3237 0.0466155412881114 1024 17177322
SGTC_2036 5160441 105 µM -1.68947291103993 0.0283013934372389 no 3238 0.0455644194235088 1020 134534 YIL048W NEO1
SGTC_3156 9099931 49.47 µM -1.69404893642736 0.0279677444790532 no 3239 0.0451279921882717 1054 18111053
SGTC_2095 5432005 200 µM -1.70222593709534 0.0273796979740414 no 3240 0.044356511196558 1053 783734
SGTC_1774 st048371 48.465 µM -1.70262135153506 0.0273515252214903 no 3241 0.0443194758497358 1051 4242727
SGTC_3317 9138495 8.753 µM -1.70552099349379 0.0271456674406833 no 3242 0.0440486501609482 1051 17020139
SGTC_159 3970-0959 50 µM -1.7076677844048 0.0269940919520514 no 3243 0.043849001517986 1026 6615653
SGTC_142 0335-0849 62.6745 µM -1.70856252048425 0.026931127458884 no 3244 0.0437660080724482 1022 3889043 YPR107C YTH1
SGTC_729 4092-0585 94.1 µM -1.71277213049593 0.0266365312553624 no 3245 0.0433772346048429 1030 2169061
SGTC_2213 7173844 200 µM -1.71319314162032 0.0266072167648534 no 3246 0.0433385064836326 1044 892728
SGTC_167 3672-0051 66.205 µM -1.73067565620381 0.0254135141142244 no 3247 0.0417548147390504 1029 3237971
SGTC_1747 st037496 66.6 µM -1.73107020256208 0.0253871008058079 no 3248 0.041719622077727 1044 723305
SGTC_2728 chlorpromazine 9.18 µM -1.73211705980341 0.0253171293113937 no 3249 0.0416263611575952 1075 2726 A thorazine and dopamine antagonist.
SGTC_1578 josamycin 24.2 µM -1.73258037699402 0.0252862130034704 no 3250 0.0415851397657952 1039 5282165 A P450 substrate.
SGTC_440 fluspirilene 35.1 µM -1.73784081015819 0.0249374069613378 no 3251 0.0411194337645781 1045 3396 An atypical antipsychotic.
SGTC_376 3970-0862 59.1 µM -1.74042033211759 0.0247678450653428 no 3252 0.0408926189635328 1029 3135186
SGTC_324 1315-0088 19.6 µM -1.74388361957974 0.0245417116714529 no 3253 0.0405896927425011 1046 6787421
SGTC_264 promethazine 12.5 mM -1.76783981934324 0.0230244881151428 no 3254 0.0385438429704768 1040 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_674 0498-0004 451 µM -1.77225363613055 0.0227537460615332 no 3255 0.0381762318770983 1005 4231473
SGTC_2255 7941087 197.44 µM -1.77335080501936 0.0226868639870481 no 3256 0.0380852976813565 1067 935561
SGTC_896 0964-0007 44.5 µM -1.77806951290506 0.0224011031236127 no 3257 0.037696219436048 1034 6756758
SGTC_754 3474-0146 171 µM -1.77879772743273 0.0223572746369387 no 3258 0.0376364649582901 1040 24762078
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.78111181860875 0.022218478074225 no 3259 0.0374470926878817 1040 6728940
SGTC_1141 3253-0389 52.6 µM -1.7866864237189 0.0218871023528335 no 3260 0.0369940922840997 1044 5402031
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.80057252106819 0.0210797620998019 no 3261 0.0358851417689114 1052 2333 A French combination drug.
SGTC_655 k060-0012 42 µM -1.80289165121408 0.0209474135601933 no 3262 0.0357026162172558 1060 5994525
SGTC_2635 hydroquinidine 100 µM -1.80732245618806 0.0206965104682212 no 3263 0.0353560083301207 1057 442912 An experimental heart treatment.
SGTC_1964 st076914 61 µM -1.81701597887138 0.0201564595213164 no 3264 0.0346073333512928 1055 24208661
SGTC_1436 4092-1007 8.32 µM -1.83121973523549 0.0193867447164064 no 3265 0.0335338761007803 1052 2881121
SGTC_95 0471-0001 561.058 µM -1.83245960203051 0.019320756387849 no 3266 0.0334414875962237 1055 4015405
SGTC_3030 9087619 49.47 µM -1.83574918905662 0.019146601960574 no 3267 0.0331973796871824 1047 25236973
SGTC_3207 9114163 49.47 µM -1.8358662579793 0.0191404288726874 no 3268 0.0331887195608251 1050 849233
SGTC_2770 toltrazuril 17.5 µM -1.83928453087554 0.0189609266331413 no 3269 0.0329366735483074 1027 68591 Kills coccidiodes.
SGTC_2851 9015922 71.43 µM -1.85628892697115 0.0180891163837943 no 3270 0.0317061932738184 1051 2996893
SGTC_1761 st044296 37 µM -1.85698195498836 0.0180543219699318 no 3271 0.0316568607111857 1057 1826700
SGTC_3144 9087057 49.47 µM -1.85850541605075 0.0179780350636802 no 3272 0.0315486374914649 1041 17249618
SGTC_977 1348-1378 135 µM -1.85857138524972 0.0179747378917074 no 3273 0.0315439581053713 1040 X977
SGTC_2655 perillic acid 100 µM -1.87096579054517 0.017364340298448 no 3274 0.0306749114219857 1074 5702197 An apoptosis inducer.
SGTC_1189 1431-2119 7.28 µM -1.87680166107458 0.0170831219170332 no 3275 0.0302726413651226 1056 3107275
SGTC_2864 9034755 47.6 µM -1.88721672397308 0.0165909096391399 no 3276 0.0295655908960396 1047 4930451
SGTC_3067 9117431 49.47 µM -1.90422753928682 0.01581308617762 no 3277 0.0284402782827267 1064 17150885
SGTC_1418 3966-3099 2.4 µM -1.91135265576344 0.0154967029131926 no 3278 0.0279796382605752 1056 740335
SGTC_663 1486-0733 13.9 µM -1.91488902328205 0.0153417022480781 no 3279 0.0277533289862607 1066 722445 YPR165W RHO1
SGTC_1829 berberine 14.4 µM -1.91513745741154 0.0153308634873514 no 3280 0.0277374879887874 999 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1293 1000-1278 195 µM -1.9254702140644 0.0148858502981093 no 3281 0.0270852794228247 1061 678847
SGTC_1163 k060-0048 49.9 µM -1.92572344618637 0.0148750849654047 no 3282 0.0270694573426452 1077 6809982
SGTC_2289 7946404 165.07 µM -1.92995414826301 0.0146962182730832 no 3283 0.0268062596290268 1047 1246120 YPR165W RHO1
SGTC_3331 9141060 1.957 µM -1.93671000057069 0.0144144292573131 no 3284 0.0263904013049734 1059 4906567 YPR165W RHO1
SGTC_1292 0kpi-0043 232 µM -1.94403957490186 0.0141139834696629 no 3285 0.0259453394738781 1066 3333905
SGTC_2512 diallyl trisulfide 49.23 µM -1.9483165928513 0.0139411700984031 no 3286 0.0256885464696376 1073 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1844 rapamycin 4 nM -1.9622540287078 0.0133906259734632 no 3287 0.0248664582444853 1011 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1745 st081495 74 µM -1.97152153906693 0.0130350302474303 no 3288 0.024332125902779 1046 13842402 YBL026W LSM2
SGTC_849 0386-0493 241 µM -1.9867119513282 0.0124698216751693 no 3289 0.0234771633236587 1068 726119
SGTC_4 0960-0234 25.671 µM -1.996105779952 0.0121310177925252 no 3290 0.02296120501795 1052 6821112
SGTC_408 cantharidin 100 µM -2.00225016190613 0.0119137523874927 no 3291 0.0226289165932156 1060 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_98 0074-0023 107.663 µM -2.01741305432541 0.0113919801788474 no 3292 0.0218262130410518 1065 3563821
SGTC_3169 9102970 49.47 µM -2.02672982500715 0.0110813244356013 no 3293 0.0213450252851915 1087 17027839
SGTC_268 camptothecin 39.6153 µM -2.03526784953077 0.0108031314379922 no 3294 0.0209119646472538 1074 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2448 5185112 27.17 µM -2.04166680914229 0.0105986399315057 no 3295 0.0205922966274391 1063 5718189
SGTC_1573 oleylamine 1.06 µM -2.06145970727076 0.00998731513508897 no 3296 0.0196296018462166 1059 5356789 An amine of the fatty acid oleic acid.
SGTC_1908 st060353 56.5 µM -2.06489427500121 0.00988442884312347 no 3297 0.0194665024556278 1068 4227716
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -2.06803052604309 0.0097912886097532 no 3298 0.0193185763577235 1054 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2881 9058953 51.95 µM -2.07658752868126 0.00954105192397179 no 3299 0.018919822465868 1050 17122249
SGTC_3193 9111931 49.47 µM -2.07870215617137 0.00948008118219772 no 3300 0.0188223673436137 1068 17087244
SGTC_1713 st033146 12.748 µM -2.08281734020889 0.00936240470742822 no 3301 0.0186339381911913 1074 674619
SGTC_867 0518-0118 155 µM -2.08810970128622 0.00921294578296335 no 3302 0.0183939700712558 1060 6848158
SGTC_795 0685-0265 78 µM -2.0980752632984 0.00893717377429241 no 3303 0.0179492486718204 1067 302754
SGTC_838 0109-0203 71.4 µM -2.10036977512912 0.00887471276965998 no 3304 0.0178481628364093 1068 759422
SGTC_523 1934-0222 13.7 µM -2.13138338991689 0.00806724190358816 no 3305 0.0165287850674304 1077 1361595
SGTC_2998 9066762 71.4286 µM -2.13612116234893 0.0079497520076098 no 3306 0.0163347696252159 1067 4945196
SGTC_3023 9089636 49.47 µM -2.13731663202539 0.0079203448781678 no 3307 0.0162861234942195 1089 17249241
SGTC_1167 k781-0610 148 µM -2.17318785202711 0.00708133261662391 no 3308 0.0148830908552748 1065 4525169
SGTC_2277 7947813 106.88 µM -2.17370183264075 0.00706990371734116 no 3309 0.0148637674742541 1072 1246798
SGTC_361 000s-0510 1.45 µM -2.2187375375022 0.00612956714453577 no 3310 0.0132522928383004 1058 660
SGTC_3325 9138760 55.175 µM -2.25796962848219 0.00540254148153912 no 3311 0.0119737765045006 1066 43844959
SGTC_687 k029-0044 34.9 µM -2.26042816343936 0.00535964538382386 no 3312 0.0118973451065049 1087 5829338
SGTC_2110 5483698 200 µM -2.26489819379041 0.00528242831310844 no 3313 0.011759463823864 1075 2848765 YHR062C RPP1
SGTC_1285 0929-0069 65.5 µM -2.26529219993095 0.00527566978221288 no 3314 0.0117473771941132 1081 1206237
SGTC_857 0438-0306 1.35 µM -2.28821792368569 0.0048954213858271 no 3315 0.011062416714197 1077 4686136
SGTC_1692 fluoroquinolonic acid 71 µM -2.2921920163471 0.00483204946183228 no 3316 0.0109472827222252 1074 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1078 idebenone 36.1 µM -2.31063778584048 0.00454738241709195 no 3317 0.0104264351505535 1080 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_662 k832-1615 104 µM -2.37181462157237 0.00370736729893604 no 3318 0.0088504846214413 1083 5878478
SGTC_3112 9123419 49.47 µM -2.3831307823939 0.00356820933121336 no 3319 0.00858304730447406 1084 17015854
SGTC_1178 0988-0033 191 µM -2.39784851886349 0.00339424280637846 no 3320 0.00824584190482485 1077 5392207
SGTC_2806 7952793 58.44 µM -2.42843375935414 0.00305688270915932 no 3321 0.00758209745964113 1070 2972490
SGTC_2529 gangaleoidin 93.61 µM -2.44077629484571 0.00292952119202098 no 3322 0.00732786509539111 1088 4565183
SGTC_44 0929-0055 61.211 µM -2.44503587752255 0.00288668988617883 no 3323 0.00724188665078081 1052 1379590
SGTC_3137 9097352 49.47 µM -2.55023842349438 0.00199283915902459 no 3324 0.00538246358628816 1072 44120435
SGTC_1564 D-Arginine 115 µM -2.5562109299278 0.00195058950694938 no 3325 0.00529094761551712 1082 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2028 5153890 36.43 µM -2.57279526295623 0.00183750307033601 no 3326 0.00504404325848506 1089 2830968 YPR165W RHO1
SGTC_97 0535-0701 19.132 µM -2.60266968253595 0.00164872371103254 no 3327 0.00462505141132516 1060 2832013 YGL099W LSG1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.60525910294186 0.0016332230470554 no 3328 0.00459024028176483 1075 6708514
SGTC_1575 cyproterone acetate 48 µM -2.62796834122295 0.00150286399469786 no 3329 0.00429482547277758 1086 9880 An androgen receptor antagonist and liver toxin.
SGTC_1264 0783-0040 158 µM -2.6486089672608 0.00139268902923584 no 3330 0.00404118943687986 1080 2855798
SGTC_356 1634-0012 32.5 µM -2.65421039288874 0.00136408990114712 no 3331 0.00397471223068679 1083 735457
SGTC_1462 k081-0014 26.5 µM -2.71552624013003 0.00108428628323504 no 3332 0.00330852662254508 1034 3270634
SGTC_2920 7982904 15.77 µM -2.81715105132089 0.000733874517173767 yes 3333 0.00242258663083725 1087 6456808
SGTC_2290 7904846 200 µM -2.87373994088434 0.00058735967011561 yes 3334 0.00202821411827775 1082 2962154
SGTC_3077 9117319 49.47 µM -2.92103234431745 0.000486182054280925 yes 3335 0.00174436803049523 1086 17154678
SGTC_2626 ethyl orsellinate 100 µM -2.98969858152516 0.000367716946137452 yes 3336 0.00139626431049596 1088 75653 A natural product.
SGTC_1892 st058411 7.36 µM -3.00034618999008 0.000351954601888968 yes 3337 0.00134836456654618 1092 3934738
SGTC_2922 7999257 32.47 µM -3.10547028124285 0.000226701674116719 yes 3338 0.00094988355146972 1090 2988377
SGTC_2447 5741742 33.78 µM -3.14151968455752 0.000194363523027767 yes 3339 0.000840367551093978 1091 1776504
SGTC_1962 st076595 64.5 µM -3.21006217860207 0.000144427634850809 yes 3340 0.000663531312234385 1086 279619
SGTC_2761 levamisole 97.89 µM -3.24078031226766 0.000126198290335878 yes 3341 0.000596015052236781 1090 26879 An alkaline phosphatase inhibitor.
SGTC_66 0109-0187 42.4 µM -3.35628526162543 7.52110272733926e-05 yes 3342 0.000394985206932921 1084 759417
SGTC_1318 1280-3875 124 µM -3.40617423590654 5.98447164407354e-05 yes 3343 0.000329400600782671 1090 373245
SGTC_1252 0493-0875 34.8 µM -3.53356793998872 3.29316318288704e-05 yes 3344 0.000204995350473082 1091 3960963
SGTC_2620 irigenin 100 µM -3.56750480080039 2.79937207690136e-05 yes 3345 0.000180198389168675 1085 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_917 harmaline 728.087 nM -3.5832418062478 2.59500105053303e-05 yes 3346 0.000169678094936522 1084 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2808 7946468 45.46 µM -3.66882042599345 1.70924348566192e-05 yes 3347 0.000121836076973927 1093 2970879
SGTC_908 3448-7491 47.7 µM -3.75785605636108 1.0965355618341e-05 yes 3348 8.56877063307016e-05 1078 1203031
SGTC_911 3456-4043 236 µM -3.873304951732 6.07826636343561e-06 yes 3349 5.36846706879691e-05 1094 914281
SGTC_2263 7948595 193.29 µM -4.0730469816495 2.10707792506136e-06 yes 3350 2.32010297677896e-05 1092 2971371
SGTC_2809 7964133 12.99 µM -4.148738446993 1.39240128599084e-06 yes 3351 1.67156254246751e-05 1092 1253665
SGTC_3140 9094243 49.47 µM -4.20778774931797 1.00294998020659e-06 yes 3352 1.28941456881692e-05 1094 19291112
SGTC_3028 9087778 49.47 µM -4.3837253986035 3.67854596293136e-07 yes 3353 5.83334091755478e-06 1094 17217395
SGTC_556 4058-0063 51.5 µM -4.54703837742798 1.40110841976563e-07 yes 3354 2.7203040242543e-06 1095 6615692
SGTC_1902 st060212 70.5 µM -5.57277046451446 1.53031999492078e-10 yes 3355 1.2535990829422e-08 1083 688944
SGTC_116 0155-0182 31.788 µM -9.95950099495959 1.10638292264927e-29 yes 3356 1.14605131900273e-23 1092 771486