SGTCid condition conc unit RSM22|YKL155C.score RSM22|YKL155C.strain.pval RSM22|YKL155C.strain.significant RSM22|YKL155C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1635 st007035 42.4 µM 32.0136000112439 1.04133011362565e-217 yes 1 3.52641006049985e-225 6 3716403 SGTC_386 1509-0011 3.07 µM 17.8257173790472 4.48325437733167e-69 yes 2 2.2316431140956e-71 13 3107280 SGTC_236 1509-0011 5.31 µM 17.386488778059 8.09237937433319e-66 yes 3 5.22198301967326e-68 73 3107280 SGTC_134 0269-0018 6.916 µM 14.632592731516 3.07393644899498e-47 yes 4 8.7013436907092e-49 19 4378915 SGTC_2513 baicalein 25.65 µM 11.6695382029766 8.74507240554297e-31 yes 5 9.12053511482614e-32 2 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2522 biochanin a 4.94 µM 8.73369266725547 4.35143162067637e-18 yes 6 1.23245146861124e-18 1 5280373 A possible chelator. SGTC_275 trichlorophene 5.69 µM 8.23386137987856 2.77915728594458e-16 yes 7 9.0636719925025e-17 72 62616 SGTC_876 0720-0963 56.8 µM 7.61001796669896 3.56547066936913e-14 yes 8 1.37028911286818e-14 1 765861 SGTC_2519 cryptotanshinone 88.04 µM 7.41729963829361 1.482134439613e-13 yes 9 5.97661586984166e-14 2 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_168 3970-0862 530.542 µM 7.37332492644403 2.04142022904199e-13 yes 10 8.32120989018648e-14 25 3135186 SGTC_503 tyrphostin 8 294 µM 5.8486169225118 4.35478506178597e-09 yes 11 2.47838580615355e-09 4 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2582 agaric acid 100 µM 5.74646916039145 7.85087215570912e-09 yes 12 4.55631209708293e-09 174 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_365 0121-0052 13.6 µM 5.59518655277631 1.84568473265616e-08 yes 13 1.10192334543039e-08 18 3101739 SGTC_581 0958-0271 211 µM 5.46772022018238 3.72997523416009e-08 yes 14 2.27930333096007e-08 19 4591145 SGTC_173 1273-0061 2.693 µM 5.41594961733886 4.94212776501008e-08 yes 15 3.04821337494587e-08 126 2847414 YPL266W DIM1 SGTC_3045 9092950 49.47 µM 5.0171266188341 3.97019000206809e-07 yes 16 2.62250011761708e-07 8 44120432 SGTC_116 0155-0182 31.788 µM 4.83767199487416 9.65870094223499e-07 yes 17 6.56843472597208e-07 44 771486 SGTC_942 3253-1115 227 µM 4.5784275339866 3.30896924749663e-06 yes 18 2.34242203254615e-06 13 46497897 SGTC_1742 st038235 28.8875 µM 4.53840534881141 3.97954448693577e-06 yes 19 2.83406134605967e-06 96 564103 YBR002C RER2 SGTC_2916 7875993 68.79 µM 4.38199455325228 8.06941665243233e-06 yes 20 5.87988749352042e-06 16 1299250 SGTC_70 0141-0289 43.283 µM 4.35734911839456 9.00158989422234e-06 yes 21 6.5823595371632e-06 147 352408 SGTC_150 3970-0969 77.2 µM 4.25241402510646 1.42473695926813e-05 yes 22 1.05739208060969e-05 51 6615640 SGTC_1738 st035555 74 µM 4.21604559656069 1.66654313404418e-05 yes 23 1.24311755812645e-05 24 5331140 SGTC_670 4204-0025 119 µM 4.10390393167681 2.6816858709129e-05 yes 24 2.03118103936148e-05 28 719039 SGTC_2163 5671233 125 µM 4.08715730129929 2.87625169966172e-05 yes 25 2.18345523154449e-05 22 701023 SGTC_1341 1486-1360 280 µM 3.97592652718824 4.55011709536926e-05 yes 26 3.5052884610079e-05 25 3976547 SGTC_1188 1403-0014 4.57 µM 3.91174260535102 5.89815956389119e-05 yes 27 4.5816271968543e-05 55 9614867 SGTC_2125 5246583 200 µM 3.84859543651636 7.58554321287048e-05 yes 28 5.93985072607447e-05 47 835267 SGTC_1757 st041620 31.8375 µM 3.8476867919023 7.61285245646111e-05 yes 29 5.96191790006409e-05 33 5289815 SGTC_879 0831-1030 162 µM 3.74560643653458 0.000113446896415611 yes 30 8.99792638438469e-05 54 1549252 SGTC_305 1682-2595 20.8 µM 3.68131836454261 0.000145135212290598 yes 31 0.000116015529519166 30 226033 SGTC_59 0330-0160 1.33 µM 3.62040240900421 0.000182653499683938 yes 32 0.000147072591376919 135 4293482 SGTC_1429 4049-0205 9.46 µM 3.5397914229929 0.000246324442488541 yes 33 0.000200221689779759 19 22774478 SGTC_2929 9013348 24.6 µM 3.5152224676359 0.000269514055736062 yes 34 0.000219692872810775 39 2995952 SGTC_2144 5628481 200 µM 3.34594171807929 0.00049354158268453 yes 35 0.000410018150806746 44 2818399 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 3.34130091824658 0.000501611775196754 yes 36 0.000416933966031154 59 6710655 SGTC_119 0121-0043 24.815 µM 3.33704172624098 0.000509125699883793 yes 37 0.000423376173979093 158 1092378 SGTC_778 3456-2434 196 µM 3.27357938422918 0.000634153394803966 yes 38 0.000530972783391228 113 5539063 SGTC_161 4065-0411 162.148 µM 3.20276722949061 0.000806755081029199 yes 39 0.000680569751145422 105 1906281 YLR208W SEC13 SGTC_2506 ethyl hematommate 54.16 µM 3.1690989438859 0.000903150538437745 yes 40 0.000764561650314378 44 3940691 An allergen. SGTC_2270 7924575 90.91 µM 3.16592361931782 0.000912767702975829 yes 41 0.000772956904215896 44 1262135 SGTC_1673 st016611 27.3 µM 3.13972035015255 0.000995796318343026 yes 42 0.000845545907533514 84 5226799 SGTC_2057 5236571 38.335 µM 3.12102319258792 0.00105921848449845 no 43 0.000901119198441313 79 54684039 YBR257W POP4 SGTC_141 0443-0274 32.331 µM 3.11893336980676 0.0010665328445775 no 44 0.000907535009144676 97 1627241 SGTC_2499 avocadenofuran 51.48 µM 3.10307371252356 0.00112356890034175 no 45 0.000957609653817614 80 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_127 0180-0333 59.125 µM 3.08595309315675 0.00118826629496307 no 46 0.00101450413983829 96 771601 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 3.05133038700867 0.001329639634906 no 47 0.00113914864370858 66 6708561 SGTC_3218 9131285 49.47 µM 3.02691881595748 0.00143838355501336 no 48 0.00123530151276983 97 17156417 SGTC_769 0302-0231 76 µM 3.01225409914715 0.00150755215144413 no 49 0.00129657717208827 113 571869 YER009W NTF2 SGTC_159 3970-0959 50 µM 2.97600557575396 0.00169173466497685 no 50 0.00146014776217362 169 6615653 SGTC_1965 Pectolinarigenin 58.4 µM 2.96313222544041 0.00176192553295661 no 51 0.00152262862474745 43 5320438 An anti-inflammatory. SGTC_3177 9107506 49.47 µM 2.94207741813877 0.00188245463661605 no 52 0.0016300920530788 34 8897194 SGTC_2232 chlorophetanol 41.5365 µM 2.93623945253665 0.00191717627301573 no 53 0.0016610888483114 201 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2759 disulfiram 3.38 µM 2.932526772247 0.00193955930214067 no 54 0.00168107966609808 87 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_87 0100-0052 35.5 µM 2.91901382902619 0.00202304486466258 no 55 0.0017557032295743 235 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_592 k241-0073 46.5 µM 2.90828574460131 0.00209163335208574 no 56 0.00181708053423375 65 4230158 SGTC_908 3448-7491 47.7 µM 2.90778662338206 0.00209487517766618 no 57 0.00181998303677779 221 1203031 SGTC_1149 3909-7961 23.3 µM 2.90063868564408 0.00214180423700957 no 58 0.00186201502228908 84 735261 SGTC_1091 telmisartan 47.6 µM 2.8964422172525 0.00216979785928988 no 59 0.00188710070102046 60 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1157 4092-0394 27.6 µM 2.8893635416576 0.00221777052327863 no 60 0.00193011254086216 90 3659885 SGTC_310 1273-0058 1.06 µM 2.88717262771529 0.00223281210413193 no 61 0.00194360445740831 369 2734232 SGTC_1156 4092-0367 4.88 µM 2.8836364911959 0.00225728431744413 no 62 0.0019655612287004 75 1357585 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.8835914526036 0.00225759757298183 no 63 0.00196584233185658 41 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1762 st045503 25.4615 µM 2.85324722859881 0.0024778259194483 no 64 0.00216374700100317 83 4645554 SGTC_2111 5486399 200 µM 2.85242951520623 0.00248402066420679 no 65 0.00216932165458133 115 689674 SGTC_2510 benzyl isothiocyanate 8.31 µM 2.82064990786101 0.00273589407854409 no 66 0.00239632375060292 68 2346 DNA damaging agent; causes G2/M arrest. SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.79263611424221 0.00297679598423521 no 67 0.00261402334968758 60 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1246 0422-0085 105 µM 2.78604893919522 0.00303614751857004 no 68 0.0026677407900446 103 264295 SGTC_1063 disulfiram 1.84 µM 2.7487510337421 0.00339276194950533 no 69 0.00299114031182269 95 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2841 9004761 38.96 µM 2.74413410699711 0.00343942837526487 no 70 0.00303353734713269 96 2991039 SGTC_2942 9052777 62.25 µM 2.74125431885352 0.00346882759631993 no 71 0.00306025568007818 115 6469503 SGTC_1339 1486-1321 22.7 µM 2.72904682668527 0.00359597390093404 no 72 0.00317588418813883 96 3469382 SGTC_1677 st019204 53.9 µM 2.7190614553393 0.00370306918032032 no 73 0.00327337216871066 90 3945625 SGTC_576 1073-0113 22.7 µM 2.71771946100718 0.00371767836345821 no 74 0.00328667731233038 178 5439563 SGTC_3006 9075424 71.4286 µM 2.68833397501388 0.00405080513015863 no 75 0.00359047676351139 80 7465181 SGTC_901 1112-0062 60.1 µM 2.60675176198914 0.00512001679894716 no 76 0.00457028000271304 73 1908457 SGTC_2332 7982454 138.89 µM 2.56878272919559 0.00569831632091356 no 77 0.00510282112590718 163 2981748 SGTC_3293 9120939 62.045 µM 2.56032480811812 0.00583477478613677 no 78 0.00522871871109596 99 934087 SGTC_2441 5730946 39.09 µM 2.551566312177 0.00597913049113091 no 79 0.0053619957246812 112 1774275 SGTC_1171 0368-0077 21.4 µM 2.54210829067841 0.00613856320686019 no 80 0.00550930146486507 84 3239779 SGTC_2208 7283366 200 µM 2.53552581081304 0.00625173493015035 no 81 0.00561393269999603 82 898663 SGTC_3088 9117578 49.47 µM 2.51986250347056 0.00652849186340389 no 82 0.00587003419347471 67 678341 SGTC_2721 ifenprodil 61.44 µM 2.50896431633664 0.00672739268831384 no 83 0.00605428578034852 115 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_66 0109-0187 42.4 µM 2.49767541223062 0.006939052452593 no 84 0.00625052998883084 127 759417 SGTC_948 3448-0295 75.3 µM 2.49613826231075 0.00696832319541126 no 85 0.00627768265884196 136 678569 SGTC_832 4083-0019 164 µM 2.46144659909899 0.0076585591074076 no 86 0.00691889978908451 295 1990758 SGTC_2187 6125751 200 µM 2.44852126928499 0.00793071773909267 no 87 0.00717219803114565 112 874498 SGTC_149 3970-0822 46.1 µM 2.44241297632248 0.00806226907298041 no 88 0.00729472327902668 263 3114250 YBL034C STU1 SGTC_2403 6032726 181.2 µM 2.43791275322704 0.00816041152794957 no 89 0.00738616944923733 144 2881040 SGTC_3200 9114385 49.47 µM 2.42659043171986 0.00841198936928265 no 90 0.0076207256521847 146 17018030 YLR208W SEC13 SGTC_2551 apiole 73.87 µM 2.42057840919205 0.00854832181230096 no 91 0.00774791852057319 63 10659 A possible DNA adduct former. SGTC_283 0987-0079 11.7 µM 2.41898305799552 0.00858482290396054 no 92 0.00778198254275232 149 411556 SGTC_3056 9094900 49.47 µM 2.40630204099775 0.00887985527995615 no 93 0.00805746753745671 142 25236784 SGTC_871 0574-0004 149 µM 2.40531669554839 0.00890314768580334 no 94 0.00807922799811993 178 9551173 SGTC_1419 3993-2473 62.6 µM 2.3946068400215 0.00915978965539366 no 95 0.00831909764675026 120 704026 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 2.38857459810051 0.00930717375619388 no 96 0.00845693709012587 140 6708760 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.3827099067388 0.00945244922735578 no 97 0.00859286556775138 162 5282362 SGTC_2425 5628681 7.85 µM 2.37397979141161 0.00967237724783731 no 98 0.00879875679426 150 5714958 SGTC_808 0711-0032 135 µM 2.34802857135608 0.0103527481489891 no 99 0.00943653676504801 116 4252555 SGTC_3146 9095609 49.47 µM 2.32519889181436 0.0109854055541979 no 100 0.0100306637938139 133 17173999 SGTC_1414 3917-0015 5.4 µM 2.31771496261914 0.0111999958054051 no 101 0.0102324086485927 109 6618702 SGTC_7 0192-1582 4.227 µM 2.30874464331475 0.011462000061512 no 102 0.0104788777275794 231 252616 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.30762641842479 0.0114950313886497 no 103 0.01050996191532 161 5106787 A p450 inhibitor. SGTC_743 1275-0778 158 µM 2.30687882626821 0.0115171606553948 no 104 0.0105307881155373 182 2849257 YMR203W TOM40 SGTC_1643 st009866 20.2 µM 2.30043240685492 0.0117095192573358 no 105 0.0107118673056769 115 3156273 YOR207C RET1 SGTC_2115 tiliquinol 12.7705 µM 2.29555225991998 0.011856989699594 no 106 0.0108507475403362 113 71208 A bioactive hydroxyquinoline. SGTC_2183 6420625 130.508 µM 2.28949974021945 0.0120421236988798 no 107 0.0110251664924205 243 2897619 SGTC_653 0203-0016 55.2 µM 2.2840295524319 0.0122115964657337 no 108 0.0111848970996272 147 295302 SGTC_1151 3909-8316 15.3 µM 2.28049613245844 0.0123221613612222 no 109 0.0112891399552502 147 800431 SGTC_2844 9010103 25.97 µM 2.27940931678667 0.0123563430462642 no 110 0.0113213725035153 183 2480525 SGTC_700 3453-2283 142 µM 2.27759276375111 0.0124136592528643 no 111 0.0113754260196672 186 565664 SGTC_1392 3455-1037 33.9 µM 2.27280991364929 0.0125656710932586 no 112 0.0115188186859623 137 981132 SGTC_2020 4017018 200 µM 2.26831402076458 0.0127100293103311 no 113 0.0116550369810425 146 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_852 0418-0143 439 µM 2.25901314526609 0.0130132312209214 no 114 0.0119412835984162 229 5369229 SGTC_1036 k216-0215 33.5 µM 2.24065470928488 0.0136300931381111 no 115 0.0125242249761164 226 622330 SGTC_2029 5175081 200 µM 2.23268525923558 0.0139056317933598 no 116 0.0127848536051425 180 1380876 SGTC_1369 1866-0067 208 µM 2.22819533381396 0.014062973181504 no 117 0.0129337460528913 204 3531355 SGTC_2923 7992654 58.14 µM 2.2226105714948 0.0142608203299187 no 118 0.0131210353764426 172 2985126 SGTC_2704 st078022 71.1 µM 2.22016813131305 0.0143480975495658 no 119 0.0132036783670518 150 54697681 SGTC_1382 3002-2117 298 µM 2.17462092840953 0.0160619410372382 no 120 0.0148292673450048 153 1497314 SGTC_435 c-PAF 6.7 µM 2.14762370094216 0.0171583944532615 no 121 0.0158718305191456 206 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3158 9100007 49.47 µM 2.13658542404004 0.0176247824403096 no 122 0.0163158630986227 146 19297233 SGTC_405 ebelactone b 50 µM 2.13608913788731 0.0176460031932649 no 123 0.0163360744762669 174 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_266 formosanin C 406 nM 2.13038560033309 0.01789145072758 no 124 0.0165698958182368 239 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_472 calcifediol 10 µM 2.12263058073781 0.0182298489640864 no 125 0.0168924101469214 129 5283731 A vitamin D metabolite. SGTC_190 3970-0790 3.722 µM 2.12216143306588 0.0182504944988785 no 126 0.0169120919927295 149 2832352 SGTC_2215 7188065 200 µM 2.11122785806299 0.0187373154593596 no 127 0.0173763657166055 130 940217 SGTC_1450 4112-4260 37.6 µM 2.10820210218321 0.0188739747686492 no 128 0.0175067557677111 198 1633175 SGTC_3076 9116187 49.47 µM 2.10368322826995 0.0190796496147309 no 129 0.0177030442140472 174 27241210 SGTC_1371 2421-0008 32.7 µM 2.1024843216618 0.0191345362061064 no 130 0.0177554358128391 239 2827552 SGTC_2639 lactacystin 53 µM 2.08919990107181 0.0197517411532025 no 131 0.018344866172206 204 3870 A proteasome inhibitor. SGTC_2640 pentamidine 10.38 µM 2.08596058348333 0.0199047797191959 no 132 0.0184910968364029 228 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2095 5432005 200 µM 2.08527189464212 0.0199374455611486 no 133 0.0185223135469032 163 783734 SGTC_1255 0566-0045 221 µM 2.0810370744269 0.0201393126088478 no 134 0.018715256354839 231 2788469 SGTC_2919 7978188 46.38 µM 2.0802225854342 0.0201783360784292 no 135 0.0187525607901226 184 2980291 SGTC_2845 9003024 42.97 µM 2.07318991141785 0.0205179574129225 no 136 0.0190773044580387 254 2990173 SGTC_543 3844-1095 191 µM 2.06396026627324 0.0209710129085143 no 137 0.019510741926219 249 4230703 SGTC_90 0870-0863 4.608 µM 2.05813012003474 0.0212615382164869 no 138 0.0197888221885445 242 1738164 SGTC_346 4513-0042 7.16 µM 2.05790179127472 0.0212729851186498 no 139 0.0197997808830198 234 2827372 SGTC_1666 st014829 29 µM 2.05715283137485 0.0213105696355094 no 140 0.0198357635614448 227 3858230 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.05079920606582 0.0216316735141095 no 141 0.0201432524592661 238 23665772 A membrane-active detergent. SGTC_2932 9016711 44.54 µM 2.044720577756 0.0219426966629324 no 142 0.0204412068543717 261 7117328 SGTC_1353 1498-1206 8.11 µM 2.04153117180449 0.0221073927346402 no 143 0.020599029372471 272 6756808 SGTC_969 1313-0238 134 µM 2.03838991055801 0.022270621311791 no 144 0.0207554772542794 253 5212874 SGTC_3167 9103034 49.47 µM 2.03764295772502 0.0223095843252681 no 145 0.0207928263271461 121 5127859 SGTC_53 0973-0023 39.979 µM 2.0320043523457 0.0226055682589475 no 146 0.0210766076678037 184 674768 SGTC_1126 isoteolin 1.0172 µM 2.03169260373806 0.0226220288122462 no 147 0.0210923925787272 227 133323 SGTC_2749 bexarotene 57.39 µM 2.01718958344964 0.0233990447104544 no 148 0.0218378663510938 254 82146 An retinoic acid receptor inhibitor. SGTC_2553 4-methylesculetin 85.09 µM 2.01679639833255 0.0234204189014075 no 149 0.0218583824863193 225 5319502 SGTC_2710 st078562 53.7235 µM 2.01365681448108 0.0235916818846152 no 150 0.0220227885104664 193 17250908 SGTC_2883 9059145 45.46 µM 2.00615383766944 0.0240052367753196 no 151 0.0224199186426547 175 16476510 SGTC_2150 5556613 200 µM 1.99130147664298 0.0248418586838153 no 152 0.0232238766138163 226 743190 SGTC_962 1254-0300 21.5 µM 1.98382062242029 0.0252724258094441 no 153 0.0236379201586431 200 7340576 SGTC_2766 oltipraz 83.91 µM 1.97545083430986 0.0257615500660021 no 154 0.0241085044172711 214 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_14 0354-0009 295 µM 1.97402943291226 0.0258453976949204 no 155 0.0241891981553241 232 1713507 SGTC_57 miconazole 162.5 nM 1.97143159799386 0.0259992325403435 no 156 0.024337264891174 212 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_118 0083-0097 135.343 µM 1.97104359153778 0.0260222745578915 no 157 0.0243594449722272 486 5207356 SGTC_2885 9057732 51.95 µM 1.96883265387155 0.0261538987481702 no 158 0.0244861555965235 223 6471414 SGTC_1389 3405-0187 19 µM 1.95462727180404 0.0270129336942233 no 159 0.0253135399826075 219 799890 SGTC_2440 5628896 157.78 µM 1.94918047991678 0.0273485018779262 no 160 0.0256369376194126 209 5522048 SGTC_163 TUB2.036 7.546 µM 1.94122937754305 0.0278445927944091 no 161 0.0261152306377888 419 15992207 YJR013W GPI14 SGTC_2951 9072950 58.06 µM 1.93829070637886 0.0280298319031338 no 162 0.0262938828065045 255 16488155 SGTC_595 3909-8003 73.7 µM 1.9340551983861 0.0282986216485366 no 163 0.0265531707568761 237 699517 SGTC_1654 st012436 41.8 µM 1.9331199226266 0.0283582634805342 no 164 0.0266107131849528 197 4323132 SGTC_1357 1503-1303 39.5 µM 1.92930414802304 0.0286026775471694 no 165 0.0268465575517434 275 292895 SGTC_2315 7733312 200 µM 1.92126119496081 0.0291235989212491 no 166 0.0273493933494202 223 726316 SGTC_1381 2324-0066 62.1 µM 1.92051468526703 0.0291723456408592 no 167 0.0273964600093168 287 10885928 SGTC_3267 9137951 49.47 µM 1.91396742927144 0.0296027890611362 no 168 0.0278121587925024 152 16643986 SGTC_257 daunorubicin 18.5 µM 1.90044398281215 0.030508574188752 no 169 0.0286874398070649 197 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2622 2-methoxyxanthone 59.94 µM 1.90030846505349 0.0305177659140456 no 170 0.0286963255605704 234 71034 A hepatoprotective. SGTC_3127 9126946 49.47 µM 1.89699576742704 0.0307431696960838 no 171 0.0289142483575891 223 27243249 SGTC_325 2810-4341 181 µM 1.895243696924 0.0308629409324441 no 172 0.0290300617594793 223 774970 SGTC_919 tnp00227 403.569 nM 1.89048547935747 0.0311901618885134 no 173 0.0293465303970266 292 1269246 A methoxyflavone. YNL221C POP1 SGTC_1530 rhein 70.4 µM 1.88860823420014 0.0313200463822098 no 174 0.0294721714206051 254 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_836 0330-0104 1.35 µM 1.88407105433875 0.0316358164987836 no 175 0.0297776824731508 242 46494820 SGTC_1867 st057372 64 µM 1.88047532239974 0.0318879301825459 no 176 0.0300216632667666 233 688837 SGTC_1133 3473-0247 50 µM 1.87990819522491 0.0319278452411336 no 177 0.0300602954058445 316 711311 SGTC_772 k072-0172 35.3 µM 1.87619206507763 0.0321904129419493 no 178 0.0303144556366321 236 5861980 SGTC_214 4373-3496 70 µM 1.87105759300884 0.032556125548713 no 179 0.0306685493237963 393 3779166 SGTC_2138 5575593 77.673 µM 1.87078647861139 0.0325755310598305 no 180 0.0306873412572292 206 762213 SGTC_2802 7925815 54.55 µM 1.86757320807079 0.0328062542461434 no 181 0.0309107918780542 301 1262923 SGTC_328 k915-0120 63.5 µM 1.86358480051737 0.0330945069196955 no 182 0.0311900168815591 260 6624543 SGTC_3192 9110362 49.47 µM 1.8616159080495 0.0332375714261628 no 183 0.0313286246715947 236 16649480 SGTC_1023 4482-3888 16 µM 1.85512197461793 0.0337130513981066 no 184 0.0317894052305668 252 3303168 SGTC_648 0375-0473 33.3 µM 1.84531937358291 0.0344413781903744 no 185 0.0324955469399935 301 1713139 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.84164394968746 0.0347177709604347 no 186 0.0327636239390307 264 7104 SGTC_335 4077-0256 27.6 µM 1.83818617123917 0.0349794570519132 no 187 0.033017488407295 282 3121989 SGTC_1335 1486-0900 202 µM 1.83618109756088 0.0351319419666292 no 188 0.0331654386616096 322 X1335 SGTC_2477 5967686 25.23 µM 1.82590587701203 0.0359219492484356 no 189 0.033932220399055 285 776118 SGTC_1319 1306-0155 43.7 µM 1.82489025906699 0.036000818867575 no 190 0.0340087957344527 319 3122360 SGTC_1525 8-methoxypsoralen 92.5 µM 1.82473228500059 0.0360130993618573 no 191 0.0340207193896989 312 4114 Related to psoralen; DNA damaging agent. SGTC_2504 purpurogallin 52.29 µM 1.81788485766208 0.0365487069045649 no 192 0.0345408665787358 254 5281571 An antioxidant. SGTC_108 0509-0257 621.132 µM 1.81335014784641 0.0369069873524295 no 193 0.0348889166488514 338 536624 SGTC_2696 st077691 74.316 µM 1.79233066502145 0.0386053888033362 no 194 0.0365400069954535 272 757133 SGTC_22 0964-0034 14.468 µM 1.7921044690483 0.0386240063688983 no 195 0.036558116579964 348 138402 SGTC_2340 7987427 183.45 µM 1.78942975427201 0.0388447099524649 no 196 0.0367728155115335 280 2239331 SGTC_2659 sanguinarine 24.21 µM 1.78922322854906 0.0388617940140664 no 197 0.0367894360933406 274 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_830 4076-0286 57.8 µM 1.78660718636909 0.0390787263823247 no 198 0.0370004996986325 475 6866659 SGTC_839 0122-0028 230 µM 1.78539246808028 0.039179790156353 no 199 0.0370988397493613 365 759448 SGTC_961 1252-1571 372 µM 1.77970853527987 0.0396555198920756 no 200 0.0375618364458303 298 6813498 SGTC_1728 st035614 33.7865 µM 1.7772208947373 0.0398652012527945 no 201 0.0377659514580161 376 15945546 SGTC_2835 9006588 71.43 µM 1.77509882829226 0.0400447801206424 no 202 0.0379407852172859 328 2345538 SGTC_2361 9034121 116 µM 1.76315546312396 0.0410677782480087 no 203 0.0389371364945962 283 6496917 SGTC_81 0411-0046 9.971 µM 1.76141972825524 0.0412181995876306 no 204 0.0390836941794654 266 12925265 SGTC_2965 9082772 38.63 µM 1.760677224823 0.0412826822877039 no 205 0.0391465248375184 325 16459634 SGTC_2828 7998861 71.43 µM 1.75627818193124 0.0416663963407274 no 206 0.0395204604071307 240 2988188 SGTC_3252 9135871 49.47 µM 1.75503681682535 0.0417751976381525 no 207 0.0396265052359228 272 17682838 SGTC_2369 9071472 200 µM 1.7538767902251 0.0418770777547203 no 208 0.0397258106866134 311 17296037 SGTC_3019 9081971 49.47 µM 1.74641553651211 0.0425371849203533 no 209 0.0403693860871155 282 16451803 SGTC_1448 4255-0083 152 µM 1.74524651525226 0.0426413681831372 no 210 0.040470983771725 289 5399660 SGTC_466 geldanamycin 89.2 µM 1.74208644256092 0.0429240269735522 no 211 0.0407466597628318 195 5288382 HSP90 inhibitor. SGTC_2218 6965428 192.983 µM 1.73725825821419 0.0433588151590162 no 212 0.0411707979248959 280 675684 SGTC_1802 st050112 57.9 µM 1.73711856074088 0.0433714479468852 no 213 0.0411831229143339 291 4662563 SGTC_1783 st039459 87.517 µM 1.72993767250206 0.044024825406243 no 214 0.0418207057926908 354 729761 SGTC_1295 1013-0063 9.78 µM 1.72730036022891 0.0442667739292015 no 215 0.0420568672684324 310 6826038 SGTC_2312 7706453 155.7 µM 1.72688756643163 0.0443047406863068 no 216 0.0420939289239024 331 976098 SGTC_1318 1280-3875 124 µM 1.72203907762948 0.0447526482962253 no 217 0.0425312199223279 357 373245 SGTC_378 3970-0959 8.33 µM 1.71509921865081 0.0454000957844435 no 218 0.0431635187820267 306 6615653 SGTC_2063 5246145 200 µM 1.71212115306833 0.0456802318132532 no 219 0.0434371719469663 343 711240 SGTC_453 enantio-paf c16 10 µM 1.71178894105642 0.0457115677762888 no 220 0.0434677854072048 529 13871343 A lipid and platelet activating factor SGTC_1187 1391-0724 117 µM 1.71173796125666 0.0457163779847223 no 221 0.0434724847557032 345 6997986 SGTC_2313 7726885 200 µM 1.70629154346264 0.0462326238878663 no 222 0.0439769058959724 328 726423 SGTC_410 α-linolenic acid 100 µM 1.70624429173768 0.0462371231035262 no 223 0.0439813026894676 338 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1050 3232-1156 69.3 µM 1.70259293368897 0.0465858628857482 no 224 0.0443221366934472 328 700529 SGTC_1212 0520-0165 585 µM 1.69940989852364 0.0468915925802308 no 225 0.0446209891013257 341 5403258 SGTC_3198 9112019 49.47 µM 1.6993893252681 0.0468935738575369 no 226 0.0446229259725572 303 45595555 SGTC_1822 st052468 42 µM 1.69007987736299 0.0477970182177576 no 227 0.0455063370246322 288 2873678 SGTC_54 0159-0055 9 µM 1.67948916841162 0.0488416921094187 no 228 0.0465283740478127 327 3319099 SGTC_1662 st014054 52 µM 1.67894707021776 0.0488956520529378 no 229 0.0465811798934529 266 2838777 SGTC_1978 st071761 42 µM 1.67774429154222 0.0490155456051059 no 230 0.0466985144352152 308 5147680 SGTC_2676 harmalol 100 µM 1.6690319131217 0.0498910261638646 no 231 0.0475555276945262 345 5459187 A monoamine oxidase inhibitor SGTC_1070 indatraline 8.81 µM 1.66749724068983 0.0500465249170123 no 232 0.0477077863157317 354 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_645 0845-0943 5.41 µM 1.66537299070952 0.0502623992452479 no 233 0.0479191822566089 321 1885106 SGTC_1242 0402-0103 60.1 µM 1.65413892993144 0.0514164153544734 no 234 0.0490496438902547 316 432868 SGTC_19 0279-0214 38.434 µM 1.65182053311808 0.0516571753428321 no 235 0.0492855708006674 431 3566274 YBR002C RER2 SGTC_1613 st002381 52.1 µM 1.64927239092758 0.0519228268126954 no 236 0.0495459215978397 349 551167 SGTC_3143 9086658 49.47 µM 1.64543602481528 0.052324825683738 no 237 0.0499399627879498 421 25236626 SGTC_98 0074-0023 107.663 µM 1.64044064234773 0.0528519732043739 no 238 0.0504567903627355 374 3563821 SGTC_1588 farnesol 29.9 µM 1.63362807556107 0.0535776629488549 no 239 0.0511684844821925 360 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1168 k815-0004 80.5 µM 1.6329130500639 0.0536542845814375 no 240 0.0512436425404236 334 642433 SGTC_3306 9127676 59.7925 µM 1.63214526821418 0.0537366561598606 no 241 0.0513244437085908 352 41905287 SGTC_1248 0469-0687 58.6 µM 1.6284778785163 0.0541314951650136 no 242 0.051711798062314 361 4017482 SGTC_1386 3228-0095 33.8 µM 1.62675352979199 0.0543179340938202 no 243 0.0518947273986358 328 870181 SGTC_3008 9078912 71.4286 µM 1.61899998700804 0.0551625432363515 no 244 0.0527236329550396 327 16648731 SGTC_3315 9136395 68.55 µM 1.61378895982789 0.0557359966433892 no 245 0.0532866050238056 367 16876844 SGTC_1934 st074720 32.6 µM 1.60991628226489 0.0561652090680059 no 246 0.0537080669537616 438 17250992 SGTC_195 4234-0266 16.654 µM 1.60938293812813 0.0562245237282454 no 247 0.0537663168567865 410 2303354 SGTC_886 0866-0150 153 µM 1.60875625664514 0.0562942817865448 no 248 0.0538348246438198 394 271463 SGTC_184 1494-0393 24.714 µM 1.60132899753926 0.0571262412753096 no 249 0.0546520348452707 406 3090647 SGTC_3242 9133940 49.47 µM 1.60131844230837 0.0571274304620361 no 250 0.0546532031622046 344 17248444 SGTC_1421 4029-0249 71.4 µM 1.59926466192294 0.0573591870476295 no 251 0.0548809040061795 389 2894095 SGTC_2052 5265182 7.135 µM 1.59738276143672 0.0575721969328395 no 252 0.0550902063430752 380 1239884 SGTC_2307 7538926 6.34 µM 1.59257269034316 0.0581194703880412 no 253 0.0556280420443348 401 96582 SGTC_857 0438-0306 1.35 µM 1.59128053749441 0.0582671815061172 no 254 0.0557732274205889 368 4686136 SGTC_3147 9097027 49.47 µM 1.59077380342817 0.058325188724988 no 255 0.0558302452546062 364 25236841 SGTC_3187 9109394 49.47 µM 1.58867671366689 0.0585657306751019 no 256 0.0560666994193139 392 17098090 SGTC_3079 9117512 49.47 µM 1.58845288784825 0.0585914500447944 no 257 0.0560919831355351 302 7185044 SGTC_180 1486-1293 102.781 µM 1.58164596049922 0.0593778637144424 no 258 0.0568652078018754 369 4140536 SGTC_2265 7929201 200 µM 1.58137873077096 0.0594089051242179 no 259 0.0568957338243426 391 1265108 SGTC_26 0302-0163 425.158 µM 1.56659903858698 0.0611456070697756 no 260 0.0586042213614868 349 3100915 SGTC_2996 9066192 71.4286 µM 1.56627276271271 0.0611843893245033 no 261 0.0586423873215843 406 6472854 SGTC_2114 5491910 81.25 µM 1.56291363822494 0.0615847847531217 no 262 0.0590364546803281 377 2849228 SGTC_2446 5162541 200 µM 1.56229643786046 0.0616585748120577 no 263 0.0591090853985435 368 1549321 SGTC_1056 3448-1962 115 µM 1.56225559976362 0.0616634596889533 no 264 0.0591138936028015 358 715507 SGTC_874 0599-0792 117 µM 1.56095980792106 0.0618186136761406 no 265 0.0592666171652478 449 765305 SGTC_1883 5-benzylidenerhodanine 20 µM 1.55948731845695 0.0619952945819146 no 266 0.0594405418872098 470 1273210 SGTC_334 1502-1024 68.5 µM 1.55482869862246 0.0625568687141169 no 267 0.0599934361262602 395 3296216 SGTC_1980 st071811 45.7 µM 1.55151660300062 0.062958532009368 no 268 0.0603889658175391 382 4974850 SGTC_725 1497-0963 19 µM 1.55139665266736 0.0629731161930166 no 269 0.0604033284576894 374 3549977 SGTC_896 0964-0007 44.5 µM 1.55098939290355 0.0630226525842533 no 270 0.0604521129656061 368 6756758 SGTC_3095 9117207 49.47 µM 1.54964809197774 0.0631860141946006 no 271 0.0606130016512849 304 17015229 SGTC_3016 9080866 49.47 µM 1.54697130468418 0.0635130146892741 no 272 0.0609350826318351 413 17066299 SGTC_2800 7887935 81.82 µM 1.5456865258473 0.0636704323084548 no 273 0.0610901464677156 381 2961002 SGTC_520 3584-0023 682 µM 1.54528562415905 0.0637196149052665 no 274 0.0611385955842143 391 1340790 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.54476458470119 0.0637835801586897 no 275 0.0612016082638106 497 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1991 st073000 8.92 µM 1.53954002391862 0.0644277362934889 no 276 0.0618362573221012 476 4301969 YIL048W NEO1 SGTC_3295 9122362 53.5725 µM 1.53602369643262 0.0648641157923809 no 277 0.0622662843409624 385 4730473 SGTC_2055 5235184 200 µM 1.53225061540572 0.0653349071374749 no 278 0.0627303012800922 417 2836034 SGTC_84 0443-0269 128.823 µM 1.53120494968719 0.0654658494948756 no 279 0.0628593739451779 418 6150058 SGTC_1367 1812-0510 76.9 µM 1.52966063628483 0.0656596066101854 no 280 0.0630503759690234 400 1142582 YDR527W RBA50 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.52367455075037 0.0664148542562215 no 281 0.0637950149118931 464 6708784 An antioxidant flavonoid SGTC_2148 5546263 113.568 µM 1.52338864585654 0.066451093675336 no 282 0.063830750477281 406 792097 SGTC_303 1348-1668 34.2 µM 1.51602286517964 0.06739001890993 no 283 0.0647567854087391 382 5380509 SGTC_1291 0993-0025 5.79 µM 1.51275072735668 0.0678103976859844 no 284 0.0651714944538393 406 4353356 SGTC_3080 9117754 49.47 µM 1.50924398071605 0.0682631625373686 no 285 0.0656182223276997 435 9550191 SGTC_1672 st016598 6.51 µM 1.50147578956237 0.069274438406002 no 286 0.0666162720288794 443 4665860 YNL267W PIK1 SGTC_931 2812-0076 566 µM 1.50100976641696 0.0693354710736769 no 287 0.0666765177674087 444 3450959 SGTC_3238 9133470 49.47 µM 1.49950054522298 0.0695334103485151 no 288 0.0668719136856996 380 3534688 SGTC_1610 st001799 48.1 µM 1.49780953435555 0.0697557085166045 no 289 0.0670913714786115 356 621897 SGTC_2937 9044753 11.33 µM 1.49761658678325 0.0697811078931137 no 290 0.0671164473922323 467 6465530 YGL099W LSG1 SGTC_1888 azatryptophan 97.5 µM 1.49528491360669 0.0700886094752588 no 291 0.0674200503276104 370 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.49425588251532 0.0702246494155847 no 292 0.0675543757257092 462 688667 SGTC_2165 5727197 32.143 µM 1.49103912926423 0.0706512203465125 no 293 0.0679756110028126 429 1361712 SGTC_3099 9120367 49.47 µM 1.48965076741841 0.0708359438970593 no 294 0.0681580429726061 423 24824940 SGTC_2164 5685496 200 µM 1.48910614575699 0.0709085078404855 no 295 0.0682297098545081 435 759046 SGTC_3303 9125618 40.5795 µM 1.48839615877037 0.0710031903444785 no 296 0.0683232245071559 521 22695467 SGTC_3033 9090887 49.47 µM 1.48824102122676 0.0710238921110301 no 297 0.0683436713289505 468 19325384 SGTC_2467 5474540 200 µM 1.48781308793401 0.0710810201458548 no 298 0.0684000965671285 438 5413519 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.48641055768422 0.071268501827902 no 299 0.0685852794670599 413 2724278 An inhibitor of dopamine biosynthesis. SGTC_1256 0570-0116 285 µM 1.48380684232918 0.0716175568262295 no 300 0.0689300856837964 405 410638 SGTC_3029 9088683 49.47 µM 1.47675452824519 0.0725695800671817 no 301 0.0698707248070358 413 25236615 SGTC_578 3460-0051 92 µM 1.47620021896764 0.0726448176859653 no 302 0.069945075393311 483 2876744 SGTC_2256 7954252 200 µM 1.46945957143787 0.0735645271044361 no 303 0.0708540898538208 349 2972920 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.46881037023052 0.0736535735274307 no 304 0.0709421152531233 348 77254 SGTC_208 k072-0098 12.366 µM 1.46831712358664 0.0737212838151348 no 305 0.071009050860942 528 5948901 SGTC_2801 7907800 81.82 µM 1.46240516066409 0.0745365538991669 no 306 0.0718151080468198 464 6620925 SGTC_1606 st000094 49.2 µM 1.45591129746159 0.0754399809478639 no 307 0.0727085710876928 457 1242210 SGTC_3254 9136651 49.47 µM 1.45163797459787 0.0760390233604279 no 308 0.0733011469838856 480 16454030 SGTC_2451 5856223 45.7 µM 1.45086359366213 0.0761479640619704 no 309 0.0734089236298533 433 2179896 SGTC_3298 9116858 71.43 µM 1.45039310621392 0.0762142107110419 no 310 0.0734744642072628 444 2506942 SGTC_425 3825-7017 13.1 µM 1.4496490205962 0.0763190706842457 no 311 0.0735782093204159 482 3397440 SGTC_31 0508-1974 57.237 µM 1.4462287577803 0.0768024824378592 no 312 0.0740565251098527 459 6810525 SGTC_1442 4112-3290 3 µM 1.44544142997952 0.076914090392905 no 313 0.0741669666813869 465 704353 SGTC_1961 st076550 68.7 µM 1.44360078636843 0.077175492517847 no 314 0.0744256518047796 405 1579337 SGTC_2136 5328288 199.296 µM 1.43653581704059 0.0781851067070317 no 315 0.0754249660579329 369 262395 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.43437501419496 0.0784958865919625 no 316 0.0757326369463004 469 4213774 SGTC_1539 benzyladenosine 56 µM 1.43225258665644 0.078802057892272 no 317 0.0760357734518346 421 92208 A nucleotide analog. SGTC_1953 st076800 12.1 µM 1.42994076215571 0.079136579308466 no 318 0.0763670107970206 497 297591 SGTC_186 3455-3465 67.277 µM 1.42662700610419 0.0796179542678404 no 319 0.0768437178223805 342 755278 SGTC_1313 1220-0047 237 µM 1.42273005164125 0.0801868786840735 no 320 0.0774072127225427 518 3528706 SGTC_2396 5342950 42.78 µM 1.42059484491737 0.0804999021920286 no 321 0.0777172890080524 521 1886677 SGTC_1502 4534-4282 27.7 µM 1.41972657579319 0.0806274550226489 no 322 0.0778436490104137 418 3278949 SGTC_1620 st003704 16.5 µM 1.41800271568433 0.080881150501097 no 323 0.0780949859569474 447 2834414 SGTC_777 1315-0167 517 µM 1.41189765308153 0.0817844621359478 no 324 0.0789900494446286 457 4221767 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.4112318139216 0.0818834385022812 no 325 0.0790881361784717 498 165521 SGTC_1573 oleylamine 1.06 µM 1.4102680502455 0.082026860924602 no 326 0.0792302743942794 483 5356789 An amine of the fatty acid oleic acid. SGTC_1312 1218-2183 165 µM 1.41023362646275 0.0820319871960685 no 327 0.0792353548727171 479 6744073 SGTC_1730 st033808 45.1 µM 1.40853796195006 0.0822847986140639 no 328 0.0794859171276625 550 1045166 SGTC_3262 9137218 49.47 µM 1.40164397060694 0.0833186878105843 no 329 0.0805107948362468 302 17650664 SGTC_1059 3448-6867 171 µM 1.39536478000625 0.0842688461851525 no 330 0.0814529332116147 474 3934407 SGTC_1704 st028805 70.8 µM 1.39379791645298 0.0845072047301822 no 331 0.0816893187616192 466 2876101 SGTC_1897 st060201 15 µM 1.39369765806767 0.084522473700177 no 332 0.0817044618728842 437 611878 SGTC_46 0329-0187a 2.197 µM 1.39266555290015 0.0846797797194019 no 333 0.0818604749549282 595 46494817 SGTC_52 0329-0193 875 nM 1.39222061010526 0.0847476623789019 no 334 0.0819278017519456 494 3739292 SGTC_745 0469-0705 296 µM 1.39012651428047 0.0850676959838631 no 335 0.0822452316021288 553 3486736 SGTC_2988 9073640 71.4286 µM 1.38885327670727 0.0852627228751231 no 336 0.0824386853878831 459 9102229 SGTC_179 1273-0063 6.77 µM 1.38821239939978 0.0853610152686834 no 337 0.0825361888408203 427 3108139 SGTC_2155 5570423 76 µM 1.38565921832558 0.0857534435584655 no 338 0.0829254932535076 475 797402 SGTC_3002 9075603 71.4286 µM 1.38244186700665 0.086249877163112 no 339 0.0834180342199022 514 20105405 SGTC_2723 salbutamol 83.58 µM 1.38230561642357 0.0862709478130083 no 340 0.0834389411063457 375 9884233 β2-adrenoceptor agonist SGTC_1066 ketoconazole 628 nM 1.38192450197454 0.0863299062010172 no 341 0.0834974418914688 537 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2926 9010726 65.15 µM 1.38098780935053 0.086474940537019 no 342 0.0836413544856937 509 2994293 SGTC_1763 st044482 94.5 µM 1.37091135742059 0.0880466815389149 no 343 0.0852012952162447 511 88505 SGTC_553 k007-0256 45.7 µM 1.36957308211894 0.08825701998248 no 344 0.0854101035227807 517 6287000 SGTC_50 0929-0078 56.389 µM 1.36672368922421 0.0887061099299112 no 345 0.0858559648554132 495 1377751 SGTC_3125 9127534 49.47 µM 1.3658951434788 0.0888370150315628 no 346 0.0859859386475358 391 1639235 SGTC_2311 7694451 200 µM 1.36569136899637 0.0888692321658893 no 347 0.0860179272530892 496 2163142 SGTC_2295 7971645 200 µM 1.3599083825831 0.0897871634415565 no 348 0.0869294589967931 507 2978226 YKL099C UTP11 SGTC_2325 6158266 200 µM 1.35867123566864 0.0899844472327289 no 349 0.0871253954249222 504 3623240 SGTC_506 n9-isopropylolomoucine 153 µM 1.35483572133075 0.090598131477095 no 350 0.0877349514125864 485 6610355 SGTC_3334 9142812 21.919 µM 1.35173421924077 0.0910966408816791 no 351 0.0882301770604113 509 45283678 SGTC_3112 9123419 49.47 µM 1.35169563139721 0.0911028559549169 no 352 0.0882363515865467 544 17015854 SGTC_387 norethindrone acetate 66.7 µM 1.35156009480699 0.0911246883747552 no 353 0.0882580416482498 466 541197 SGTC_1273 0849-0096 14.1 µM 1.35059888487921 0.09127963273474 no 354 0.0884119791114727 508 5286025 SGTC_2405 ticlatone 3.52 µM 1.34880794171704 0.091568848668395 no 355 0.0886993315844265 495 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1494 4358-1428 177 µM 1.34821929724773 0.0916640558438417 no 356 0.0887939298717585 534 1564571 SGTC_8 0354-0001 70 µM 1.34783339909071 0.0917265106827101 no 357 0.0888559865074471 624 4993152 SGTC_2269 7935389 174.42 µM 1.34661476294026 0.0919239451378575 no 358 0.0890521684992311 517 97605 SGTC_1172 0370-0043 85 µM 1.34401468733288 0.0923462420204964 no 359 0.0894718187564378 488 376585 SGTC_3228 9131799 49.47 µM 1.34228820852434 0.0926274438937337 no 360 0.0897512825944261 505 17015818 SGTC_2507 purpurin 79.67 µM 1.3409681267485 0.0928428803834181 no 361 0.0899654006275956 536 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2994 9053520 71.4286 µM 1.33528186432017 0.0937751107424873 no 362 0.0908920559951086 525 4647384 SGTC_726 3448-4391 34.2 µM 1.33325074206647 0.0941097711115611 no 363 0.0912247662715682 562 1356692 SGTC_906 1165-0455 526 µM 1.32675007527917 0.0951867837919605 no 364 0.0922956851356356 508 3252859 SGTC_2596 sinensetin 100 µM 1.3256296839739 0.0953733204979215 no 365 0.0924811944310863 499 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2110 5483698 200 µM 1.31985814091487 0.0963385039169134 no 366 0.0934411927467775 513 2848765 YHR062C RPP1 SGTC_2728 chlorpromazine 9.18 µM 1.31939811562974 0.0964157423779353 no 367 0.0935180257079881 426 2726 A thorazine and dopamine antagonist. SGTC_3120 9124077 49.47 µM 1.31809906228951 0.0966340997050985 no 368 0.0937352441900239 527 18774327 YGL155W CDC43 SGTC_3183 9108214 49.47 µM 1.31366712608329 0.097381795483317 no 369 0.0944791241971972 373 4974831 SGTC_2665 lovastatin 100 µM 1.31340850655591 0.0974255569264376 no 370 0.0945226663128995 523 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2777 climbazole 1.536 µM 1.31209766837744 0.0976475879165077 no 371 0.0947435913017047 574 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.3078293568522 0.0983731292061038 no 372 0.0954655972726032 535 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2417 cerulenin 830 nM 1.30580713358457 0.0987182482223888 no 373 0.0958090767749916 507 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1534 6-azauridine 81.6 µM 1.30429681341611 0.0989765816948463 no 374 0.0960662006946344 599 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1587 estradiol valerate 56.1 µM 1.30217757551518 0.0993399011207166 no 375 0.0964278445227755 554 13791 A steroid. SGTC_3082 9117008 49.47 µM 1.3017772418518 0.0994086431594698 no 376 0.0964962728748616 537 41448529 SGTC_1446 4239-0190 62 µM 1.29993131654254 0.0997260602693912 no 377 0.0968122552984897 605 1340085 SGTC_2475 5812728 15.03 µM 1.29597199004091 0.100409384596201 no 378 0.097492567546692 572 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_329 k048-0121 21.3 µM 1.29568818441052 0.100458496383789 no 379 0.0975414668556872 521 6832902 SGTC_2117 5521686 200 µM 1.29525466015799 0.100533550401002 no 380 0.0976161971913537 540 803312 SGTC_2685 mycophenolic acid 18.85 µM 1.2945809765892 0.100650263238859 no 381 0.097732409169306 496 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3336 9143619 71.43 µM 1.2934459766971 0.100847120648893 no 382 0.0979284286212616 596 45595730 SGTC_1182 1222-0449 220 µM 1.28931749384237 0.10156554344928 no 383 0.0986438658172935 521 658318 SGTC_1049 3226-0134 66 µM 1.287980128885 0.101799063907935 no 384 0.0988764402102915 585 5702385 SGTC_1129 3453-1384 223 µM 1.28664902777401 0.102031878477256 no 385 0.0991083234308366 607 1084452 SGTC_3276 9139060 49.47 µM 1.28455073274778 0.102399664474068 no 386 0.0994746621846331 494 4870619 SGTC_1473 k844-0725 134 µM 1.28030378374649 0.10314701163073 no 387 0.100219158748653 640 54682906 SGTC_188 3229-0966 278.469 µM 1.27960097056439 0.103271068599668 no 388 0.100342754175995 658 5722370 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.27918482921826 0.10334457477394 no 389 0.100415988436572 507 15053 SGTC_23 0213-0011 39.996 µM 1.27534670106398 0.104024323488363 no 390 0.101093277395076 556 627608 SGTC_1616 st002734 56.1 µM 1.27484372413485 0.104113642537433 no 391 0.101182280555128 585 4026101 SGTC_3163 9099914 49.47 µM 1.27171807385602 0.104669944597076 no 392 0.101736653266948 494 16268368 SGTC_2860 9025725 38.96 µM 1.2628159096059 0.106266138867407 no 393 0.103327672876968 517 40546248 SGTC_1006 4099-6547 255 µM 1.25898771623408 0.106957928497442 no 394 0.104017384382666 580 3146833 SGTC_1896 st058441 89 µM 1.25839798565879 0.107064786342161 no 395 0.104123930019614 532 688759 SGTC_21 0849-0113 22.993 µM 1.25672897295947 0.10736762493128 no 396 0.104425896528837 590 1560156 SGTC_218 alverine citrate 93.75 µM 1.25637134350265 0.107432596242374 no 397 0.104490683189834 544 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1397 3532-0190 20.1 µM 1.25229852651961 0.108174513365962 no 398 0.105230552802024 488 5322280 SGTC_3259 9138485 49.47 µM 1.24746067052406 0.109060576008855 no 399 0.106114316250929 637 17646153 SGTC_1249 0481-0015 10.2 µM 1.24700391488554 0.109144500389422 no 400 0.106198031053595 514 4227577 SGTC_898 1000-0849 28.3 µM 1.24685243081493 0.109172344350922 no 401 0.106225805794528 592 6751807 SGTC_292 k038-0015 474 µM 1.24169226696518 0.11012387312134 no 402 0.107175062105734 551 46368540 SGTC_2850 9015429 58.44 µM 1.23779244538656 0.11084693288179 no 403 0.107896515178014 551 6457570 SGTC_1526 st051518 75 µM 1.23538918239713 0.111294208473113 no 404 0.108342848416943 550 673993 SGTC_45 0kpi-0036 14.9 µM 1.23001862828572 0.112298398040902 no 405 0.109345064590784 554 2795021 SGTC_1513 0337-0559 19 µM 1.22829074134485 0.112622851925751 no 406 0.109668922682147 539 775073 SGTC_3349 9149703 23.001 µM 1.22739094378522 0.112792076217134 no 407 0.109837844285339 569 4910494 SGTC_2591 skatole 100 µM 1.22708455258807 0.112849740405881 no 408 0.109895406590606 573 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_538 2922-0838 53.3 µM 1.22631711713466 0.112994267547484 no 409 0.110039681184557 677 777039 SGTC_1254 0550-0035 264 µM 1.22626383548024 0.113004306707444 no 410 0.110049702951062 638 15121435 SGTC_2870 9038528 12.99 µM 1.22498607644162 0.11324524871145 no 411 0.110290233308058 543 6463316 SGTC_3310 9130229 44.1445 µM 1.22285011506077 0.113648836531822 no 412 0.110693156490181 593 7761258 SGTC_2692 st077426 47.7 µM 1.22021655822381 0.114147854664452 no 413 0.111191395740372 619 25238571 SGTC_1200 1643-0193 18.4 µM 1.22002530074695 0.11418415567712 no 414 0.111227641938367 635 5403974 SGTC_1779 st039427 55 µM 1.21761179250721 0.114642950530906 no 415 0.111685765498167 699 1124498 SGTC_2680 butyl paraben 22.24 µM 1.21642036393472 0.11486991766433 no 416 0.111912415225672 561 7184 An antifungal and steroid mimetic. SGTC_2453 5731132 22.18 µM 1.21594690733972 0.11496019983087 no 417 0.112002573830343 654 1362040 SGTC_100 0086-0128 49.5915 µM 1.21411490401873 0.11531001503824 no 418 0.112351924723118 670 93297 SGTC_504 lovastatin 124 µM 1.21230141714973 0.115657039102213 no 419 0.112698510808003 532 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_86 0417-1630 471.922 µM 1.20911875250691 0.116267857592439 no 420 0.113308612878309 731 3634867 SGTC_2584 androsterone 48.74 µM 1.2076953034146 0.116541786145711 no 421 0.113582242617791 771 2754130 A steroid. SGTC_983 1491-0821 12.2 µM 1.2072916832341 0.116619542043139 no 422 0.113659916222363 597 46495113 SGTC_1745 st081495 74 µM 1.20425273927085 0.117206164444907 no 423 0.11424595366468 682 13842402 YBL026W LSM2 SGTC_1614 st002383 48.6 µM 1.2014760118955 0.117743994715085 no 424 0.114783303082288 628 1947235 SGTC_2358 9037157 4 µM 1.20138912358047 0.117760852434563 no 425 0.114800146583846 619 2388925 SGTC_1328 1441-0025 69.2 µM 1.20038141170591 0.117956489402226 no 426 0.11499562233594 567 4562601 SGTC_2803 7707263 71.43 µM 1.19293343476038 0.119409569394363 no 427 0.116447721800118 590 2199229 SGTC_2347 9049783 174.81 µM 1.18943603686639 0.120096242570416 no 428 0.117134063531915 674 6467988 YPL169C MEX67 SGTC_3265 9137266 49.47 µM 1.18937660066502 0.120107936171886 no 429 0.117145752216714 556 17224265 SGTC_1824 st053723 68.6 µM 1.1853795127865 0.120896173624474 no 430 0.11793371413326 623 675225 SGTC_697 0508-1955 564 µM 1.1794795023767 0.122066313848504 no 431 0.119103647024613 695 6243113 SGTC_2950 9072895 21.46 µM 1.17741468828083 0.122477697965716 no 432 0.119515015041778 649 17332245 SGTC_1719 st032227 49.2 µM 1.17737812243021 0.122484991934945 no 433 0.119522308990634 619 3125804 SGTC_1077 5-fluorocytosine 377 nM 1.17624121064032 0.122711929380146 no 434 0.119749250405798 604 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3300 9124615 50.48 µM 1.17473553827151 0.123012928321291 no 435 0.120050268349837 625 24824903 SGTC_2280 7785178 200 µM 1.17242076665141 0.123476683143527 no 436 0.120514083004137 609 2954328 SGTC_2470 5664817 21.68 µM 1.16927557199661 0.124108770129156 no 437 0.121146310924423 648 2859561 SGTC_1343 1487-0095 224 µM 1.16857623766574 0.124249621835165 no 438 0.121287203329634 622 4560101 YGL055W OLE1 SGTC_864 0469-0573 172 µM 1.16809168200016 0.124347280898201 no 439 0.12138489259378 631 689425 SGTC_619 1652-1634 108 µM 1.16314741210778 0.125346835517618 no 440 0.122384849271155 612 5400454 SGTC_603 3794-0023 45.9 µM 1.16223971539131 0.125530947034572 no 441 0.122569053232154 638 3802260 SGTC_884 0851-0618 334 µM 1.15796190941637 0.126401170511036 no 442 0.123439790526467 685 9642473 SGTC_3077 9117319 49.47 µM 1.15230430854768 0.127558525058139 no 443 0.124598023552674 602 17154678 SGTC_2328 6201408 200 µM 1.15151776005828 0.127720007887876 no 444 0.124759646531629 638 2890418 SGTC_1109 tnp00067 928.257 nM 1.1468201270764 0.128687416817466 no 445 0.125727984503763 668 676295 SGTC_1198 1612-1005 86.7 µM 1.14472473917539 0.129120566952415 no 446 0.126161600031459 687 6998509 SGTC_523 1934-0222 13.7 µM 1.14262266795411 0.129556113238283 no 447 0.126597644917147 684 1361595 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.14158735653808 0.129771002014581 no 448 0.126812790966407 698 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1794 st048918 76.9 µM 1.13965627658365 0.130172475354635 no 449 0.127214764856559 579 672303 SGTC_2773 thioridazine 9.09 µM 1.13865254404085 0.130381491413448 no 450 0.127424051741752 683 5452 An antipsychotic. SGTC_1583 clindamycin 39.6 µM 1.13380373511811 0.131394470392239 no 451 0.128438441949229 618 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_763 3453-1109 128 µM 1.13318438027351 0.131524251948179 no 452 0.12856841608109 705 1560353 SGTC_38 0929-0051 58.268 µM 1.13118821150781 0.131943137447667 no 453 0.128987941289028 717 1379719 SGTC_1836 st055642 81 µM 1.1256564306183 0.133108757230947 no 454 0.130155486171627 677 8571 SGTC_2045 5106652 78.05 µM 1.12383952921242 0.133493144055089 no 455 0.130540554309062 685 673349 SGTC_1044 1222-0021 1.78 µM 1.12347718895542 0.133569892606352 no 456 0.130617441640413 690 4306703 SGTC_462 ag-879 158 µM 1.12211052672672 0.133859643120705 no 457 0.130907724312683 720 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_774 k060-0086 136 µM 1.12119318988119 0.134054372829973 no 458 0.131102818951737 780 5911235 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.12092678493666 0.134110960979867 no 459 0.131159514246296 748 1377 SGTC_89 0302-0250 142.109 µM 1.1206928415142 0.134160667377815 no 460 0.131209315165931 732 4203518 YLR208W SEC13 SGTC_559 1550-0661 158 µM 1.1205552109001 0.134189915924534 no 461 0.131238619509506 687 5830875 SGTC_1951 sophoraflavanone G 9.2 µM 1.11932222308441 0.134452139505318 no 462 0.131501349207469 725 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1860 st056228 74.6 µM 1.11871044887183 0.134582378039587 no 463 0.131631843040787 662 688679 SGTC_1005 4092-0690 4.4 µM 1.1180408291242 0.134725030345367 no 464 0.131774777964386 651 1529343 SGTC_937 3122-0005 46.7 µM 1.11658511851061 0.135035505223335 no 465 0.13208587871062 742 759535 SGTC_196 k015-0023 18.111 µM 1.11570552282597 0.135223343591425 no 466 0.132274102879265 712 5211998 SGTC_1289 0976-0073 69.1 µM 1.11568193973657 0.135228382243774 no 467 0.132279151954579 728 3391136 SGTC_1227 3909-8010 46.6 µM 1.11488550921476 0.135398619432364 no 468 0.132449743568313 678 15982272 SGTC_1716 st033144 30.6155 µM 1.11285560777346 0.135833175321554 no 469 0.132885224154618 719 674617 SGTC_3007 9078383 71.4286 µM 1.11200095109613 0.136016423352018 no 470 0.133068870702881 708 6496995 SGTC_3122 9126309 49.47 µM 1.11154035526748 0.13611525044 no 471 0.133167914822864 679 17591206 SGTC_2278 7948257 134.34 µM 1.11090393187708 0.136251884571479 no 472 0.133304851443353 693 1247028 SGTC_1402 3909-7673 35.9 µM 1.10851880228487 0.136764784296808 no 473 0.133818911757231 683 5328014 SGTC_3189 9110682 49.47 µM 1.10805232892316 0.136865249125341 no 474 0.133919608548768 687 17122418 SGTC_629 3448-6466 76.7 µM 1.1070785740039 0.137075130201205 no 475 0.134129979100991 713 573744 SGTC_2764 methyldopa 94.69 µM 1.1068286983738 0.137129023301361 no 476 0.134183998952824 728 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2037 5169046 200 µM 1.10591479781261 0.137326256375177 no 477 0.134381699603706 677 5718022 SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.10208396565028 0.138155113241289 no 478 0.135212584785421 701 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1735 st034310 56.75 µM 1.10198714091705 0.138176106800362 no 479 0.135233631042993 696 871153 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.1003442329158 0.138532654043024 no 480 0.135591083254032 655 17037758 SGTC_1336 1486-0901 104 µM 1.09950310827175 0.138715439051941 no 481 0.135774339475468 694 5006114 SGTC_2526 patulin 37.61 µM 1.09701120201616 0.139257919763729 no 482 0.136318247626064 758 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2880 9042983 58.44 µM 1.09566016410716 0.139552639490509 no 483 0.13661376094687 699 6464714 SGTC_563 tetrahydrosecaminediol 614 µM 1.09556997845858 0.139572327967966 no 484 0.13663350289231 745 334274 A psychoactive constituent of the cannabis plant. SGTC_2967 9089538 49.85 µM 1.09550563855521 0.139586375201372 no 485 0.136647588308395 729 728216 SGTC_2724 maprotiline 69.64 µM 1.09549954846826 0.139587704890616 no 486 0.136648921613445 730 4011 A tricyclic antidepressant. SGTC_2711 st079103 59.1 µM 1.09285642694074 0.140165608434332 no 487 0.137228421046397 689 54693780 SGTC_2282 7944268 200 µM 1.09176661777693 0.140404361591006 no 488 0.137467847701026 727 2970414 SGTC_1856 st057054 55.7 µM 1.09163350864873 0.140433541778176 no 489 0.137497110769447 747 1266018 SGTC_618 k072-0232 33.2 µM 1.08400928261508 0.142111799243046 no 490 0.139180341549537 687 5872756 YGL099W LSG1 SGTC_748 act1.228 77.9 µM 1.08166331839097 0.142630916761128 no 491 0.139701079040611 746 4421505 YNR035C ARC35 SGTC_330 1488-0319 80.1 µM 1.08154451980106 0.142657238708152 no 492 0.139727484148852 716 6846614 SGTC_13 0199-0087 65 µM 1.08152212036773 0.142662202070222 no 493 0.139732463203118 737 4589825 SGTC_516 3992-2719 87.3 µM 1.07670442017103 0.143732442362502 no 494 0.140806168517898 673 5350887 YDR037W KRS1 SGTC_1699 st031318 29.054 µM 1.07658148542787 0.143759822714167 no 495 0.140833639633588 736 5340658 SGTC_2171 5739187 198.077 µM 1.07371389245993 0.144399499153076 no 496 0.141475466451608 661 2262761 SGTC_1723 st034307 2.5525 µM 1.07260509110219 0.144647353895444 no 497 0.141724169766628 717 867466 SGTC_3121 9125696 49.47 µM 1.07249615105866 0.144671721145042 no 498 0.141748620903703 721 1235365 SGTC_527 4476-4215 268 µM 1.07215153027555 0.144748822675824 no 499 0.141825988411072 727 4418754 SGTC_3264 9137442 49.47 µM 1.07089324654725 0.145030571703783 no 500 0.142108716413457 688 17015726 SGTC_775 4577-0580 57.3 µM 1.06967603264368 0.145303475615856 no 501 0.142382579065678 739 2006902 SGTC_2181 6316240 54.2555 µM 1.0693080587935 0.145386044694201 no 502 0.142465440249703 677 12779990 SGTC_2370 9071495 200 µM 1.0692241608886 0.145404874831716 no 503 0.142484337134856 693 21791103 SGTC_549 1661-1316 519 µM 1.06875116912102 0.145511064314685 no 504 0.142590903947564 769 2857282 SGTC_1012 4112-3522 18 µM 1.06870829942458 0.145520691395146 no 505 0.142600565313544 741 3112398 SGTC_2016 5121758 140 µM 1.06848806685385 0.14557015491652 no 506 0.142650205194203 782 2795203 SGTC_3090 9117696 49.47 µM 1.06717654919863 0.145864951645249 no 507 0.142946060001735 731 7923821 SGTC_1854 st056233 32.9 µM 1.06669412419479 0.145973489717582 no 508 0.143054990651389 714 5393174 SGTC_2720 fluspirilene 36.88 µM 1.0665431401072 0.146007469919893 no 509 0.143089094091587 658 3396 An atypical antipsychotic. SGTC_1464 k208-0027 110 µM 1.06310638088168 0.146782377994553 no 510 0.143866855549742 761 X1464 SGTC_3291 9121177 71.43 µM 1.06222155041636 0.146982332192617 no 511 0.144067559348088 639 17015612 SGTC_2829 7992743 58.44 µM 1.0605583015881 0.147358687760345 no 512 0.144445340584337 745 16462845 SGTC_2817 7995342 71.43 µM 1.06047901349276 0.147376644974343 no 513 0.144463366302967 648 18879975 SGTC_1812 st052057 4.327 µM 1.05981801826507 0.147526404627333 no 514 0.144613698974888 758 3645418 SGTC_2119 5528445 120.635 µM 1.05970076012556 0.147552982086232 no 515 0.144640378443678 737 791935 SGTC_2979 9012552 45.46 µM 1.05936923141401 0.147628142971421 no 516 0.144715828330157 687 17100905 SGTC_2488 5268135 45.7 µM 1.05890302303887 0.147733880466772 no 517 0.144821973691807 813 1270356 YLR208W SEC13 SGTC_573 3702-0553 84.7 µM 1.05773299530756 0.147999469670115 no 518 0.145088594031796 724 1222756 SGTC_3180 9109287 49.47 µM 1.05670783113725 0.148232438245493 no 519 0.145322474932815 694 18891271 SGTC_304 1310-0298 97 µM 1.05261275376456 0.149165491061882 no 520 0.146259254751819 766 1550234 SGTC_459 nigericin 15.3 µM 1.05206880180698 0.149289723575791 no 521 0.146383992290773 774 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_612 0302-0167 22.4 µM 1.05113516853893 0.149503115925201 no 522 0.146598256915989 827 235821 SGTC_1820 st053765 18.6 µM 1.0499858706821 0.149766080244518 no 523 0.146862304477835 712 3690829 SGTC_2120 5538279 151.968 µM 1.04478512215363 0.150959889252899 no 524 0.148061146309046 761 2058197 SGTC_2099 5377090 177.372 µM 1.04258135897544 0.151467658684429 no 525 0.148571113221019 744 2243829 SGTC_2683 piperine 63.03 µM 1.04192711596147 0.151618621281251 no 526 0.148722735645955 745 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1332 1480-0653 17.5 µM 1.04175843395487 0.151657559839891 no 527 0.148761844880148 757 5749438 SGTC_590 k048-0076 22.4 µM 1.04085627483097 0.151865927102121 no 528 0.148971128817796 751 6832814 SGTC_539 4859-0462 2.54 µM 1.04034740399779 0.1519835423609 no 529 0.149089264001352 774 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1060 3448-7350 82 µM 1.03956295892657 0.152164969558517 no 530 0.149271496735882 766 570178 SGTC_2018 5133068 143 µM 1.03829797166102 0.152457839823137 no 531 0.149565676361007 729 785362 SGTC_189 3970-0742 2.116 µM 1.03767311430852 0.152602644939123 no 532 0.149711132975798 762 2891807 SGTC_1360 1598-0022 39.8 µM 1.03766363821855 0.152604841640583 no 533 0.149713339581423 846 761525 SGTC_1413 3910-0535 34.4 µM 1.03744348764602 0.152655881789428 no 534 0.149764610028293 799 2876951 SGTC_1196 1588-0294 184 µM 1.03592843202327 0.153007442419633 no 535 0.150117766074408 712 6144269 SGTC_3221 9128209 49.47 µM 1.03489923273987 0.153246568565945 no 536 0.150357986502443 734 16460723 SGTC_3338 9144300 39.5675 µM 1.03433509925265 0.153377745439578 no 537 0.150489766787764 779 4901274 SGTC_274 sirtinol 40.1 µM 1.03323725673221 0.153633237818708 no 538 0.150746440769775 767 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1920 st075728 45.7 µM 1.02888971041568 0.154647774699284 no 539 0.151765752049922 762 3400306 SGTC_1508 1080-0625 72.9 µM 1.02737929874889 0.15500127599592 no 540 0.152120947681348 734 767111 SGTC_2207 7258803 200 µM 1.02362636668599 0.155881931927867 no 541 0.153005893272369 730 3666799 SGTC_2863 9028737 58.44 µM 1.02341597678115 0.155931399075337 no 542 0.153055604269125 765 6460917 SGTC_1817 st052116 64.4 µM 1.01971809512927 0.156802538940115 no 543 0.15393108863598 772 4361398 SGTC_3066 9117245 49.47 µM 1.01970002645304 0.156806803371718 no 544 0.153935374567959 804 17176980 SGTC_157 1348-1695 65.819 µM 1.01961785152849 0.156826198635517 no 545 0.153954867647208 802 5380510 SGTC_2101 5377231 179.231 µM 1.01909817892819 0.156948890457205 no 546 0.154078179321057 781 2844213 SGTC_842 0271-0008 11.1 µM 1.01737132848433 0.157357043716555 no 547 0.154488408074827 835 1221709 SGTC_2727 riluzole 51.77 µM 1.01611325447529 0.157654837297175 no 548 0.154787728989672 724 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_67 0335-0847 266 µM 1.01498342944661 0.157922588931629 no 549 0.155056863235134 895 4552207 YOR254C SEC63 SGTC_2226 7298446 200 µM 1.014068775353 0.158139566850411 no 550 0.155274968064448 754 3283010 SGTC_456 gingerol 170 µM 1.01369481474953 0.158228335614301 no 551 0.155364199533849 787 442793 A herb. SGTC_403 arphamenine a 50 µM 1.01226001986549 0.158569222881386 no 552 0.155706872665917 773 5487158 An arginine aminopeptidase inhibitor. SGTC_2356 9061756 188.97 µM 1.01090755932185 0.158890989284753 no 553 0.156030337830186 786 20104043 SGTC_440 fluspirilene 35.1 µM 1.01081218357021 0.158913696448131 no 554 0.156053165354107 796 3396 An atypical antipsychotic. SGTC_349 k015-0014 24 µM 1.00715238474217 0.159786631768024 no 555 0.156930775361351 740 2196908 SGTC_32 0928-0142 34.1 µM 1.00710196437891 0.15979867990057 no 556 0.156942888661324 790 2244242 SGTC_694 1315-0438 43.2 µM 1.00031727766142 0.161425326230858 no 557 0.158578494204855 728 6793154 SGTC_1356 1502-0781 85.8 µM 1.00013121268257 0.16147008738693 no 558 0.158623506386566 778 567702 SGTC_2017 5132927 60.65 µM 1.00013067156462 0.161470217574034 no 559 0.158623637304123 792 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1621 st003705 32.4 µM 0.998127252426132 0.161952687679004 no 560 0.159108828336363 845 24207032 SGTC_2560 caryophyllene 100 µM 0.99666667061983 0.162305021164943 no 561 0.159463166332761 892 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3027 9089541 49.47 µM 0.99365435564406 0.16303325095948 no 562 0.160195585803124 785 9943819 SGTC_1868 st057644 42.7 µM 0.992115223401745 0.163406156116145 no 563 0.160570660583468 870 688665 SGTC_2285 7945142 200 µM 0.990734987087572 0.163741034347397 no 564 0.160907501109366 758 2970608 SGTC_1087 pterostilbene 9.05 µM 0.989604982126435 0.164015531907642 no 565 0.161183616944071 824 5281727 Similar to reservatol, lowers cholesterol. SGTC_467 ro 31-8220 72.8 µM 0.985401444423342 0.165039262430878 no 566 0.162213460220029 832 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2564 betulinic acid 100 µM 0.98398158359131 0.165385988351293 no 567 0.162562284017201 879 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.982891266793684 0.165652560237898 no 568 0.162830478241883 829 2724 A muscle relaxant with antifungal properties. SGTC_2140 5586273 200 µM 0.982694552906511 0.165700684445824 no 569 0.162878896202818 790 854421 SGTC_2913 7966556 36.57 µM 0.982318969503296 0.165792592507214 no 570 0.162971366016959 810 2976516 SGTC_1807 st050092 58.9 µM 0.981217650914373 0.1660622833425 no 571 0.16324271083832 784 5008496 SGTC_3271 9137798 49.47 µM 0.978024068419753 0.166845929359558 no 572 0.164031210155171 752 6498326 SGTC_1017 4239-0030 168 µM 0.976727587385979 0.167164741506612 no 573 0.164352016830853 821 1149593 SGTC_1217 1183-1422 255 µM 0.975942372310611 0.167358021246764 no 574 0.16454651137865 871 2849664 SGTC_692 k241-0027 77.8 µM 0.97584838284923 0.167381166286019 no 575 0.164569802174062 806 3600480 SGTC_1988 st071872 53.4 µM 0.974636201933983 0.167679852400591 no 576 0.164870374714767 866 16414116 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.973598361803129 0.167935852848267 no 577 0.165128000029384 695 88881 An O-methylated flavonoid and antioxidant. SGTC_1393 3470-5649 58.2 µM 0.97148790226615 0.16845720813979 no 578 0.165652687283008 715 4108395 SGTC_2319 6033012 152.6 µM 0.969267451298038 0.169006857320517 no 579 0.16620588232096 761 847246 SGTC_2991 9074669 71.4286 µM 0.969249911860276 0.169011203603393 no 580 0.166210256777107 867 17333109 SGTC_2627 acetyl isogambogic acid 100 µM 0.969214055257499 0.169020089113804 no 581 0.166219199891331 777 6857789 A caspase activator and apoptosis inducer. SGTC_724 3910-0327 137 µM 0.967950823268818 0.169333318075985 no 582 0.166534465119271 842 2885483 SGTC_2229 7354935 190 µM 0.967681810705704 0.169400070087086 no 583 0.166601652492831 790 318112 SGTC_1480 1070-0044 41.2 µM 0.967293332116018 0.169496495856169 no 584 0.166698708035947 847 3124987 SGTC_2302 7771753 200 µM 0.966489617742983 0.169696100681185 no 585 0.166899619804956 831 2203047 SGTC_2212 7123476 200 µM 0.964809509436805 0.170113847300214 no 586 0.167320116011177 763 1085715 SGTC_2255 7941087 197.44 µM 0.964574071296552 0.170172439872057 no 587 0.167379095783687 912 935561 SGTC_2081 5214970 32.255 µM 0.963836792759153 0.170356007149095 no 588 0.167563878598689 848 2063512 SGTC_1202 1988-0068 29.6 µM 0.962766985885479 0.170622592638853 no 589 0.167832235983521 839 2850480 SGTC_2145 5634607 200 µM 0.961045802612941 0.171052054971857 no 590 0.168264569268736 787 308662 SGTC_690 glyoxal 20.3 µM 0.958003479741966 0.171812852023293 no 591 0.169030501942494 822 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1596 piperlongumine 63 µM 0.957320043310603 0.171984056539088 no 592 0.169202870866654 904 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3229 9132204 49.47 µM 0.956371562326197 0.172221836539638 no 593 0.169442273372329 847 17682924 SGTC_2785 7756463 72.73 µM 0.956349901482377 0.172227269266612 no 594 0.169447743241729 849 2201551 SGTC_3161 9100388 49.47 µM 0.956234531607206 0.172256206871435 no 595 0.169476878741031 899 25236368 SGTC_3110 9122132 49.47 µM 0.955485051982032 0.172444270344749 no 596 0.169666230534611 869 918317 SGTC_1850 st056238 17 µM 0.954411730507735 0.172713821930851 no 597 0.169937635365904 893 5393177 SGTC_2583 asiatic acid 100 µM 0.951075402601616 0.17355341388215 no 598 0.170783050106348 825 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_537 1334-0398 209 µM 0.950604770247065 0.17367205791155 no 599 0.170902523088684 888 5846986 SGTC_3039 9090270 49.47 µM 0.942703609407874 0.175671601266596 no 600 0.172916263329974 829 17173750 SGTC_997 3996-0078 137 µM 0.942315975097468 0.175770073629687 no 601 0.173015445822104 873 735687 SGTC_793 0488-0545 106 µM 0.940010715275879 0.176356410500653 no 602 0.17360603219179 856 292548 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.939117804106463 0.176583852260711 no 603 0.173835132071739 938 1273210 SGTC_861 0443-0273 110 µM 0.936911382947636 0.177146665540765 no 604 0.174402071715879 882 6149169 SGTC_3168 9103419 49.47 µM 0.936039390799185 0.177369405095302 no 605 0.174626453458077 809 16649256 SGTC_222 nsc-310342 10.666 µM 0.933498348530444 0.178019490633457 no 606 0.175281361368426 808 432556 SGTC_2131 toluylene red 5.2905 µM 0.933431756652565 0.17803654729033 no 607 0.175298545142674 842 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_589 1227-0070 34.1 µM 0.932858349140297 0.178183460915902 no 608 0.175446554911147 865 2841384 SGTC_2546 rhodinyl acetate 100 µM 0.932160600921525 0.178362335098203 no 609 0.17562676671068 901 6708682 SGTC_1176 0848-0131 83.3 µM 0.9304123953437 0.178811000343516 no 610 0.176078801586544 937 6769040 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.930155266607184 0.178877050590036 no 611 0.176145349643197 858 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2329 6138490 200 µM 0.929650190337772 0.179006837350877 no 612 0.176276115892066 749 720019 SGTC_829 1635-0120 117 µM 0.928931481025091 0.179191622376378 no 613 0.176462298455707 919 285054 SGTC_2592 piperlongumine 83.33 µM 0.928485023174812 0.179306470100734 no 614 0.176578016543146 808 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1281 0884-0031 11.8 µM 0.921966965092266 0.180988456346882 no 615 0.178272903647181 890 1548255 SGTC_2485 5633444 17.78 µM 0.921000248683701 0.181238756968281 no 616 0.178525148593636 852 5724239 SGTC_3126 9127922 49.47 µM 0.919685089427592 0.181579623738206 no 617 0.178868673352102 873 45595682 SGTC_1351 1496-0003 46.5 µM 0.917619478087041 0.18211580418448 no 618 0.179409058401608 922 3891978 SGTC_634 1611-4317 11.2 µM 0.916443229000245 0.182421570499658 no 619 0.179717235348364 947 2843522 SGTC_3335 9143315 29.6265 µM 0.914957187863362 0.182808325598134 no 620 0.180107052943109 874 4899691 SGTC_2418 pentamidine 31.67 µM 0.913813879396919 0.183106229653893 no 621 0.180407326077254 846 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1638 st008370 60.6 µM 0.912860963374536 0.183354755710226 no 622 0.180657835270245 864 24207134 SGTC_3206 9114350 49.47 µM 0.91172564045762 0.183651128962046 no 623 0.180956581451626 820 17087243 SGTC_1214 0358-0031 63.7 µM 0.91119884444349 0.183788749093351 no 624 0.181095306396492 852 4301366 SGTC_1827 berberine 7.24 µM 0.909317138462678 0.184280850103318 no 625 0.181591373256953 807 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1889 st059080 5.18 µM 0.908370069015147 0.184528836214216 no 626 0.18184136691182 950 176925 Isolated from Daphnopsis sellowiana. SGTC_2607 solasodine 47.35 µM 0.907742828548086 0.184693190659293 no 627 0.182007055192197 894 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2626 ethyl orsellinate 100 µM 0.907401487539818 0.18478266972392 no 628 0.182097261545178 871 75653 A natural product. SGTC_508 roscovitine 141 µM 0.906220734974893 0.185092399743617 no 629 0.182409515102592 928 160355 A CDKinase inhibitor. SGTC_1364 1653-0028 37.6 µM 0.905724541650696 0.185222655261586 no 630 0.182540834679605 875 5718652 SGTC_2768 sulfasalazine 50.2 µM 0.904154648987891 0.185635142019208 no 631 0.182956701947162 925 5384001 An antioxidant and salicylic acid derivative. SGTC_2173 5763948 167 µM 0.899611905917496 0.186831947890974 no 632 0.184163409491829 931 2867177 SGTC_2072 5231554 129 µM 0.898693267148959 0.187074546570331 no 633 0.184408032124445 1010 789545 SGTC_1922 5578187 25 µM 0.897405971396334 0.187414829681705 no 634 0.184751163665515 882 1350412 SGTC_1305 1181-0477 144 µM 0.896724962983294 0.187595001738853 no 635 0.184932848389082 921 6252086 SGTC_1390 3413-2614 145 µM 0.894762583522603 0.188114779973388 no 636 0.185457007878898 946 3421432 SGTC_271 rotenone 740 µM 0.894617207827967 0.188153321170349 no 637 0.185495874967881 929 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_217 ketoconazole 989 nM 0.892770965754907 0.188643210447415 no 638 0.185989918886895 914 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1778 st046819 58.9 µM 0.892619111756856 0.188683538963813 no 639 0.186030590434445 990 671715 SGTC_3342 9147791 14.508 µM 0.889018525720037 0.189641318367549 no 640 0.186996561779793 941 1838168 SGTC_2840 9008771 71.43 µM 0.887689585433755 0.189995579470834 no 641 0.187353874767388 893 2992978 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.887361673964798 0.19008305471552 no 642 0.187442105403807 889 279621 SGTC_1173 0443-0020 122 µM 0.884908575697139 0.190738239928325 no 643 0.18810297119941 915 5331295 SGTC_732 3970-1727 52.7 µM 0.883583555509758 0.191092708404987 no 644 0.188460529659194 942 1275699 SGTC_1821 st053465 65.6 µM 0.882436978817915 0.191399765585631 no 645 0.18877027295642 884 675086 SGTC_2856 9022925 19.48 µM 0.880043341111211 0.192041763744787 no 646 0.189417915455062 909 4944862 SGTC_1967 st070177 51.4 µM 0.878326457722242 0.192503060032356 no 647 0.189883290830182 908 5729214 SGTC_185 k048-0037 25.491 µM 0.878260490675288 0.192520797717445 no 648 0.189901185753912 969 6827589 SGTC_1759 st043059 70 µM 0.87760316655746 0.192697598238269 no 649 0.190079555129104 934 669426 SGTC_210 3551-0445 56.827 µM 0.876251160271582 0.193061559248644 no 650 0.190446754788121 935 2865180 YOR207C RET1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.874366731299974 0.193569548478246 no 651 0.190959284497097 1086 688664 SGTC_665 3914-0008 307 µM 0.873664379653062 0.193759091147845 no 652 0.191150527343288 914 1069549 SGTC_2336 9001819 198.65 µM 0.872030202073681 0.194200542099243 no 653 0.191595950698946 972 2989602 SGTC_1037 k284-1091 78.7 µM 0.87103070565045 0.1944708441844 no 654 0.191868693809763 895 3334711 SGTC_2756 carbadox 75.1 µM 0.869106028576941 0.194991995194856 no 655 0.192394569800661 902 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_799 1310-0557 151 µM 0.86901701766798 0.195016117490338 no 656 0.192418911391295 937 5354492 SGTC_2851 9015922 71.43 µM 0.868759703792912 0.19508586073316 no 657 0.192489288962241 932 2996893 SGTC_1489 4065-0444 182 µM 0.86799166555559 0.195294122622007 no 658 0.192699447632058 932 2877968 SGTC_1104 tacrolimus 29.8 µM 0.867264568087313 0.195491407399994 no 659 0.192898532802335 968 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2791 5663188 71.43 µM 0.866790829167736 0.195620013004585 no 660 0.193028313919428 926 54690634 SGTC_1058 3448-5425 97.3 µM 0.860620240302934 0.197299826878559 no 661 0.194723617302364 937 7279705 SGTC_2198 6589944 200 µM 0.860100875727044 0.197441610026369 no 662 0.194866719266759 876 5290268 SGTC_767 0929-0023 86 µM 0.859664635633183 0.197560748327543 no 663 0.194986967119686 1012 1204563 SGTC_2351 9026858 72.31 µM 0.859062219550816 0.197725341148938 no 664 0.195153094872193 902 1409300 SGTC_1837 st055472 66.5 µM 0.858846486382885 0.197784304161292 no 665 0.19521260833106 964 676091 SGTC_1563 conessine 56.1 µM 0.85843181071947 0.197897670884753 no 666 0.195327034242504 1076 441082 An anti-amoebic, histamine inhibitor. SGTC_77 0828-0286 12.516 µM 0.858163164761266 0.197971136007789 no 667 0.195401186354394 996 745345 SGTC_2166 5933061 31.504 µM 0.856383051926924 0.198458349671942 no 668 0.195892968031361 1022 2877375 SGTC_2194 5927483 104.545 µM 0.854803499049165 0.198891275609612 no 669 0.196329970397515 1018 760979 SGTC_1144 3486-0183 12.5 µM 0.854153959969016 0.199069467178477 no 670 0.196509844561304 983 6744069 SGTC_564 3555-0129 330 µM 0.854008163928651 0.199109477408908 no 671 0.196550232972716 882 563260 SGTC_1691 st019933 84.6 µM 0.852886554251489 0.199417438274445 no 672 0.196861109370819 966 6176082 SGTC_1433 4060-0023 7.6 µM 0.852524194267792 0.199516992869931 no 673 0.196961608230951 979 3840627 SGTC_1697 st025554 27.742 µM 0.852257261954452 0.199590348847476 no 674 0.19703566053148 937 1269519 SGTC_3205 9113483 49.47 µM 0.851746015481664 0.199730890385994 no 675 0.197177537445036 960 17018033 SGTC_2959 9079155 11 µM 0.850509271054177 0.200071117269051 no 676 0.197521004109748 916 16189457 SGTC_3239 9133757 49.47 µM 0.850068116298587 0.200192562656319 no 677 0.197643608369356 984 17036923 SGTC_1105 epirubicin 18.1 µM 0.848762015470529 0.200552378504311 no 678 0.198006865154221 940 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_342 k048-0088 23.3 µM 0.847770301407791 0.200825843596493 no 679 0.198282952846266 973 6820570 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.847144631830884 0.200998487011462 no 680 0.198457255256876 1000 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2531 methyl deoxycholate 70.07 µM 0.84638706851154 0.201207643495621 no 681 0.198668425021425 942 16667744 Haematoxylin. SGTC_2261 9010538 184.68 µM 0.845331614798329 0.201499262330183 no 682 0.198962857132553 850 6457250 SGTC_2026 5148700 152 µM 0.845032294536356 0.201582009733261 no 683 0.199046404129225 979 79838 SGTC_2814 7977482 42.97 µM 0.844130402973822 0.201831461665503 no 684 0.199298270059612 1023 6456762 SGTC_1674 st016616 23.6 µM 0.843430060717907 0.20202529500732 no 685 0.199493982819522 961 625830 SGTC_1841 st054148 70 µM 0.8427826690935 0.202204572288838 no 686 0.199675001221522 904 675442 SGTC_1267 0828-0272 9.49 µM 0.841869758898483 0.202457539297518 no 687 0.199930429649367 1016 745334 SGTC_2869 9037858 32.47 µM 0.841513184090243 0.202556397384012 no 688 0.200030251116057 989 27187042 SGTC_2414 st077232 92.9 µM 0.840956461509585 0.20271080284465 no 689 0.200186162922718 908 729801 SGTC_995 3931-2021 34.6 µM 0.838410999871984 0.203417675028862 no 690 0.200899956851788 938 730143 SGTC_2775 cyproheptadine 69.59 µM 0.837436002084273 0.203688820001424 no 691 0.201173768036028 1042 2913 A selective serotonin reuptake inhibitor. SGTC_368 fentichlor 4.58 µM 0.837080856662311 0.203787638764633 no 692 0.201273560031197 915 7329 A pesticide. SGTC_904 1141-0088 396 µM 0.836897425588822 0.203838689418254 no 693 0.201325113785223 969 1378119 SGTC_1904 st060225 78 µM 0.834778238746858 0.20442903228388 no 694 0.201921290246096 958 66595 SGTC_1769 st044406 64.4 µM 0.833941567369612 0.204662384140764 no 695 0.202156956024396 979 670903 SGTC_964 1287-0107 19.4 µM 0.833705497551563 0.204728253853061 no 696 0.202223479721054 1009 51516812 YPR165W RHO1 SGTC_2083 5306046 65.942 µM 0.832356715987246 0.205104841301705 no 697 0.202603813012141 990 539837 SGTC_623 k072-0108 16.9 µM 0.83215991679931 0.205159823144967 no 698 0.202659342732088 971 5382803 SGTC_2702 st077768 96.8 µM 0.831295127523357 0.20540153213374 no 699 0.202903463239759 895 6484119 SGTC_1260 0700-1617 7.75 µM 0.830274154996799 0.20568711200208 no 700 0.203191898541297 985 2853078 SGTC_972 1319-0219 195 µM 0.828446401649097 0.206198947578755 no 701 0.203708868621292 957 23903702 SGTC_1775 st081588 35.1725 µM 0.826816187444973 0.206656101628628 no 702 0.204170626808984 1070 1426443 YGL099W LSG1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.826369168502356 0.206781562030348 no 703 0.204297353750818 965 803109 SGTC_1016 4226-1401 38 µM 0.825005732040285 0.207164502713432 no 704 0.20468416821658 1031 2901613 SGTC_129 0088-0017 176.636 µM 0.823937839375814 0.207464728408533 no 705 0.204987439309587 969 182446 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.823754604035035 0.207516268746745 no 706 0.205039503193933 991 616764 SGTC_2818 7996756 12.99 µM 0.823574859489171 0.207566834547812 no 707 0.205090582851354 976 2241621 SGTC_1564 D-Arginine 115 µM 0.822680152310814 0.207818642201716 no 708 0.205344952495311 996 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3213 9129884 49.47 µM 0.822305097719328 0.207924251739285 no 709 0.205451638074731 965 17190742 SGTC_2027 5150920 200 µM 0.821156156763802 0.208247972802795 no 710 0.205778663109169 1014 786715 SGTC_856 0433-0016 11.3 µM 0.819973524911548 0.208581496857347 no 711 0.20611560003053 1007 3911780 SGTC_2667 digitoxin 100 µM 0.819720263152269 0.208652962276781 no 712 0.20618779790288 979 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1358 1509-0022 2.48 µM 0.81967843841573 0.208664765772066 no 713 0.206199722412353 1030 3258434 SGTC_1612 st002233 45.4 µM 0.819630234168182 0.208678370138153 no 714 0.206213466269782 1034 1035021 SGTC_2005 4024620 188 µM 0.818065222951686 0.209120336854392 no 715 0.206659972744797 1003 236743 SGTC_3022 9087993 49.47 µM 0.818025184923752 0.209131651012462 no 716 0.20667140332445 1028 17173644 SGTC_27 0485-0001 32.618 µM 0.815923649002987 0.209726019961636 no 717 0.207271902671292 961 2054479 SGTC_1296 1068-0102 11.9 µM 0.814177548086629 0.210220617280634 no 718 0.207771622809626 1003 767053 SGTC_1793 st048256 72.231 µM 0.814057609082994 0.210254616106021 no 719 0.207805974494279 990 672022 SGTC_2742 clothiapine 36.27 µM 0.81274222638325 0.210627696374515 no 720 0.208182932826983 975 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_621 3584-0052 32.1 µM 0.811104107021367 0.211092856664154 no 721 0.20865294375552 1057 2273927 SGTC_1893 st059353 36.1 µM 0.810840768389359 0.211167690423427 no 722 0.208728559467846 983 3112488 SGTC_1013 4112-3890 241 µM 0.808196045087565 0.211920111326032 no 723 0.209488867052412 962 705171 SGTC_2428 5615643 7.78 µM 0.808025255524177 0.211968754618741 no 724 0.20953802174073 1002 2253075 SGTC_3323 9138564 53.9225 µM 0.807779879005596 0.212038652765514 no 725 0.209608655063583 1090 43912313 YNL103W MET4 SGTC_110 0850-0284 111.64 µM 0.806056078871135 0.212530075646028 no 726 0.210105257423121 903 3906265 SGTC_1498 4478-3555 97.6 µM 0.804437303188547 0.212992163170547 no 727 0.210572232413627 1018 3437919 SGTC_966 1300-0360 30.2 µM 0.804141150162183 0.213076764905738 no 728 0.210657730772999 994 70588 SGTC_2977 9011197 71.43 µM 0.80401316462646 0.213113332469848 no 729 0.210694686058595 952 2704722 SGTC_230 MPP+ 141.667 µM 0.803046154958994 0.213389741267004 no 730 0.210974028938831 991 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_428 3448-4153 16.5 µM 0.80147376295461 0.213839637671284 no 731 0.211428713641588 970 3834874 SGTC_2682 pyrogallin 40.03 µM 0.800555459029249 0.214102640179101 no 732 0.211694522549657 1096 822798 An ATP competetive kinase inhibitor. SGTC_1033 k072-0102 21.3 µM 0.800268025249307 0.214184999961531 no 733 0.211777762257371 1042 5965931 SGTC_347 4534-1311 26.2 µM 0.800124038980158 0.214226263968127 no 734 0.211819467321504 1049 2862016 SGTC_1224 0823-0416 294 µM 0.798083466243963 0.214811554317059 no 735 0.212411027727043 1048 3598164 SGTC_1989 st071868 50.2 µM 0.798054131706165 0.214819975007984 no 736 0.21241953881815 1073 16414057 SGTC_133 0724-0033 378.92 µM 0.795339478467461 0.215600065480647 no 737 0.213208027426201 981 280309 SGTC_2357 9067248 200 µM 0.79471057619022 0.215781022706125 no 738 0.213390939386575 1003 9150235 SGTC_343 4130-2827 29.8 µM 0.794069761238635 0.215965498143886 no 739 0.213577410123196 1037 1118244 SGTC_455 paf C-16 10 µM 0.79315484089238 0.216229040322927 no 740 0.213843807267731 1008 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1229 0139-0193 12.2 µM 0.792849690659471 0.216316980030426 no 741 0.213932700800342 1097 3090752 SGTC_1463 k081-0032 34.1 µM 0.790962661934256 0.216861253006383 no 742 0.214482890145764 912 977755 SGTC_1185 1319-0113 81.3 µM 0.78689201710287 0.21803803538177 no 743 0.215672540512766 1036 4672763 SGTC_2806 7952793 58.44 µM 0.785646794671814 0.218398750584845 no 744 0.216037220822204 1051 2972490 SGTC_1051 3253-3903 78 µM 0.785193007800324 0.218530288667659 no 745 0.216170207225833 1093 5509239 SGTC_2671 danthron 100 µM 0.782554424706827 0.21929603144487 no 746 0.216944406808033 1046 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_557 1315-0110 16.2 µM 0.782529986411064 0.219303130878849 no 747 0.216951584850547 1097 6833801 SGTC_1235 benzylparaben 21.5 µM 0.782187462315015 0.219402649556345 no 748 0.217052205840823 1018 7180 SGTC_3038 9091290 49.47 µM 0.779151238542877 0.22028594304645 no 749 0.217945315026204 1061 25236843 SGTC_823 0417-1665 178 µM 0.776912502020063 0.220938536628976 no 750 0.218605197350226 1070 3429856 SGTC_652 0437-0092 114 µM 0.776848131941352 0.220957316914265 no 751 0.218624187850378 1065 3091274 SGTC_674 0498-0004 451 µM 0.776456967892086 0.221071460584988 no 752 0.218739609726969 1036 4231473 SGTC_142 0335-0849 62.6745 µM 0.772868400406262 0.22212019643534 no 753 0.219800133815375 1109 3889043 YPR107C YTH1 SGTC_2471 5466956 24.79 µM 0.771710470131129 0.222459199136026 no 754 0.220142964057316 1052 724419 SGTC_1591 genipin 88.4 µM 0.771453330939336 0.222534520786033 no 755 0.220219137257077 1022 442424 A DNA cross-linking agent. SGTC_287 k060-0039 29.6 µM 0.770754700050142 0.222739238345133 no 756 0.220426171313692 1105 5861974 SGTC_2204 7233102 200 µM 0.770552451408786 0.222798522639834 no 757 0.220486127006575 1026 2172480 SGTC_1782 st039423 80.636 µM 0.770549858342311 0.222799282792892 no 758 0.22048689577005 1018 2068169 SGTC_3247 9135149 49.47 µM 0.770421601722675 0.222836882848564 no 759 0.22052492178138 1023 8934436 YOR116C RPO31 SGTC_286 k060-0067 22.9 µM 0.77041364439463 0.22283921575937 no 760 0.22052728112412 1049 5985051 SGTC_2895 9054447 58.44 µM 0.770289114161277 0.222875727054554 no 761 0.220564206144021 1098 2697450 SGTC_315 k915-0449 187 µM 0.770278944816474 0.222878708777816 no 762 0.220567221658656 1108 20970215 YNL149C PGA2 SGTC_71 0417-1750 47.813 µM 0.769899833699343 0.222989883032566 no 763 0.220679656287722 1086 6811472 SGTC_2718 lomofungin 53.02 µM 0.768825036794485 0.223305238641213 no 764 0.220998591876318 1079 5351222 A RNA synthesis inhibitor. SGTC_945 3381-0768 11.3 µM 0.759500287229503 0.226051839345199 no 765 0.223776671153155 1131 1126236 YIL048W NEO1 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.759215348490185 0.226136067500157 no 766 0.223861873035342 1092 279621 SGTC_977 1348-1378 135 µM 0.759138703945017 0.226158726725203 no 767 0.223884794299039 1139 X977 SGTC_1370 2001-0092 44.6 µM 0.75898556501304 0.226204004625015 no 768 0.223930595914652 1164 790957 SGTC_3343 9148379 18.9835 µM 0.758973402278933 0.226207600945487 no 769 0.223934233838815 1135 1955036 SGTC_1118 chelidonine 707.474 nM 0.758002607252472 0.226494753247546 no 770 0.224224710947691 1150 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2243 6634756 200 µM 0.757133972165383 0.226751861943767 no 771 0.22448480146421 1066 885676 SGTC_10 0279-0212 42.575 µM 0.756988842755529 0.226794835081416 no 772 0.224528273431717 1151 39851 YBR002C RER2 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.755918836547824 0.227111808058266 no 773 0.22484892977554 1101 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1646 st011709 75.6 µM 0.755450446197856 0.227250640087976 no 774 0.224989377289613 1087 5757843 SGTC_1901 st060216 58.6 µM 0.754107724842085 0.227648890887955 no 775 0.225392269636339 1133 688792 SGTC_2971 9092186 9.93 µM 0.751299188127728 0.228483171262172 no 776 0.226236308855833 1059 25236400 SGTC_2984 9022109 38.96 µM 0.751052354008516 0.228556575760569 no 777 0.226310574278964 1104 6459207 SGTC_685 1278-0033 54.9 µM 0.750714546900594 0.228657055628608 no 778 0.226412233223798 1120 3590572 SGTC_2555 cholic acid 100 µM 0.749543483945279 0.229005577320058 no 779 0.226764849981905 1095 6708657 Influences liver metabolism. SGTC_704 1310-0270 142 µM 0.749005387776365 0.229165820761503 no 780 0.226926979039225 1133 5718033 SGTC_2184 6075246 200 µM 0.747807309968618 0.229522830554506 no 781 0.227288196128735 1085 2267320 SGTC_932 2857-0803 154 µM 0.746973100029804 0.229771596931289 no 782 0.227539899297272 1148 674898 SGTC_2833 9001315 45.46 µM 0.745819712430323 0.230115792536717 no 783 0.227888165199364 1088 2989378 SGTC_1098 clofazimine 15.1 µM 0.744594965423271 0.230481598899063 no 784 0.228258306204056 1122 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3003 9075612 71.4286 µM 0.744042194412752 0.230646806456246 no 785 0.228425474358192 1099 6501993 SGTC_654 1124-0271 80.9 µM 0.743928808487207 0.230680702465323 no 786 0.228459772854836 1113 5403748 SGTC_1964 st076914 61 µM 0.742100317286101 0.231227702550737 no 787 0.229013278809095 1155 24208661 SGTC_2077 5212015 200 µM 0.741454116950495 0.231421188752126 no 788 0.229209071091144 1068 780900 SGTC_484 loperamide 105 µM 0.740204606522733 0.231795574834122 no 789 0.229587926437986 1086 3955 An opioid-receptor agonist. SGTC_791 1348-1292 225 µM 0.74005650343097 0.231839972758782 no 790 0.229632854987729 1156 5437054 SGTC_3347 9188721 44.724 µM 0.739513481457936 0.232002798862039 no 791 0.229797628244729 1087 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3322 9139058 2.11 µM 0.739058624277795 0.232139237585928 no 792 0.229935699930001 1123 4908926 YPR165W RHO1 SGTC_473 2-arachidonoylglycerol 10 µM 0.738756799705338 0.232229797372024 no 793 0.230027344261629 1059 5282280 An endocannabinoid. SGTC_2958 9077254 16.72 µM 0.738451496544111 0.232321420874431 no 794 0.230120065603888 1144 16457351 SGTC_2921 7974240 10.71 µM 0.738242735069024 0.232384083152376 no 795 0.230183479027438 1116 2979074 YDR527W RBA50 SGTC_96 0929-0093 37.281 µM 0.737927404929813 0.232478751124378 no 796 0.230279282298646 1080 6991579 SGTC_451 chloral hydrate 100 µM 0.737761527619193 0.23252855918487 no 797 0.230329687917825 1184 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2064 5220758 200 µM 0.737637055228093 0.232565938466584 no 798 0.230367515755473 1167 788518 SGTC_2034 5197015 53.07 µM 0.737156390217621 0.232710314383933 no 799 0.230513625071669 1117 780676 SGTC_2973 9094665 17.96 µM 0.737129277660162 0.232718459585917 no 800 0.230521868107345 1152 25237061 YIL048W NEO1 SGTC_1631 benzylvanillin 81.9 µM 0.736883420802135 0.232792327566025 no 801 0.230596623531597 1114 75506 SGTC_1286 0929-0070 131 µM 0.736581811940535 0.232882964092958 no 802 0.230688349452381 1158 1420408 SGTC_650 1328-0195 38 µM 0.736347942128415 0.232953257839319 no 803 0.23075948845954 1125 2780821 SGTC_2924 9010168 62.78 µM 0.736073332232652 0.2330358117859 no 804 0.230843035509346 1164 2993929 SGTC_477 mead ethanolamide 10 µM 0.735422615445247 0.233231496815332 no 805 0.231041076379312 1008 16061185 SGTC_2437 5741531 144.16 µM 0.734805485198892 0.233417165856592 no 806 0.231228983015572 1179 2262990 SGTC_2174 5790901 200 µM 0.732322695626588 0.234164962758961 no 807 0.231985814974103 1138 786020 SGTC_226 1,3-diallylurea 8.28947 mM 0.731973552466172 0.234270228244305 no 808 0.232092355247382 1117 74537 YKL182W FAS1 SGTC_2738 aclarubicin 5.55 µM 0.731253900305715 0.234487283558757 no 809 0.232312041437442 1047 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1160 4092-0570 10.5 µM 0.72931853453154 0.235071563549569 no 810 0.232903418624656 1134 4994975 SGTC_1491 4138-0063 26.5 µM 0.729019619448761 0.235161876584178 no 811 0.232994830666864 1121 23883227 SGTC_1913 st060213 96.1 µM 0.728935917068904 0.235187169527778 no 812 0.23302043149202 1164 688959 SGTC_3212 9128307 49.47 µM 0.728486907511193 0.235322875581258 no 813 0.233157790154036 1067 27243542 SGTC_1368 1852-0141 284 µM 0.728166015955175 0.235419886469362 no 814 0.233255983159138 1118 2838987 SGTC_3337 9144342 33.5465 µM 0.72590103248184 0.236105256206506 no 815 0.233949721760673 1153 17682949 SGTC_3051 9093778 49.47 µM 0.725864156966385 0.236116423591585 no 816 0.233961025758907 1131 17217378 SGTC_3083 9117465 49.47 µM 0.724218783392973 0.236615004740175 no 817 0.234465714346215 1153 16420915 SGTC_1441 4106-0040 13 µM 0.721574003731319 0.237417638330502 no 818 0.23527821341398 1158 2904180 SGTC_289 k017-0060 526 µM 0.72116363645863 0.237542309769456 no 819 0.235404420932163 1147 5512909 SGTC_1384 3089-0840 101 µM 0.720616618205993 0.237708552250684 no 820 0.235572713231312 1134 1069836 SGTC_2038 4100038 30.985 µM 0.720453988612975 0.237757988770107 no 821 0.235622759656778 1137 3596803 SGTC_993 3909-8757 62.7 µM 0.720395772865694 0.23777568669808 no 822 0.235640675964649 1085 4288324 YLR208W SEC13 SGTC_565 1418-0001 44.5 µM 0.718650584090131 0.238306569676211 no 823 0.236178118913681 1178 2862145 SGTC_984 1492-0255 2.91 µM 0.714451438253998 0.239586597773749 no 824 0.237474037226581 1102 1585198 SGTC_2461 5755302 26.15 µM 0.714083028727493 0.23969907907532 no 825 0.237587919791686 1158 2788904 SGTC_831 k061-1017 217 µM 0.713879093086868 0.239761356266838 no 826 0.237650973157562 1220 1240153 SGTC_3296 9122258 64.045 µM 0.713409420258871 0.239904816975188 no 827 0.237796222772021 1153 4730474 SGTC_2383 9036125 200 µM 0.712995786595988 0.24003119938509 no 828 0.237924182193807 1121 79580 SGTC_1378 2093-0007 380 nM 0.712238454778553 0.240262690025106 no 829 0.238158563983164 1170 3618014 SGTC_2022 5136654 200 µM 0.712204657047077 0.240273023679696 no 830 0.238169026775519 1153 1713771 SGTC_1418 3966-3099 2.4 µM 0.710068876035522 0.240926529551253 no 831 0.238830712888972 1175 740335 SGTC_2904 7225135 42.03 µM 0.709619099962904 0.2410642750842 no 832 0.238970186032257 1239 4446116 SGTC_2147 5545932 89.7195 µM 0.708834438847521 0.241304682840417 no 833 0.239213611807903 1170 797404 SGTC_1972 st070201 17.4 µM 0.706968227206091 0.2418769835923 no 834 0.239793111447334 1155 2829099 SGTC_3227 9130768 49.47 µM 0.705847590206832 0.2422209966675 no 835 0.240141461518506 1180 17720899 SGTC_1796 st049173 110.4 µM 0.704868118668404 0.242521891849093 no 836 0.240446156061082 1144 94134 SGTC_400 oxethazaine 37.5 µM 0.703785367471172 0.242854750153384 no 837 0.240783223776964 1133 4621 A local anesthetic. SGTC_2703 st077852 53.4 µM 0.70369214635412 0.242883419650888 no 838 0.240812256152976 1162 6281836 SGTC_1269 0831-0796 3.05 µM 0.703497607694261 0.242943254542544 no 839 0.240872848554581 1171 927758 SGTC_637 1181-0519 7.26 µM 0.703391273640257 0.242975963425585 no 840 0.240905971624552 1203 6252091 YGR060W ERG25 SGTC_1427 4048-4900 550 nM 0.703246007247918 0.243020651939175 no 841 0.240951226126545 1176 24132586 SGTC_2952 9073731 13.78 µM 0.702983240238346 0.243101498632708 no 842 0.241033097067995 1216 16457353 SGTC_1914 st062367 72.6 µM 0.702705023212656 0.243187114751029 no 843 0.241119798292356 1171 978205 SGTC_2158 5657123 3.6195 µM 0.70210509704779 0.243371786339136 no 844 0.241306811943327 1158 2858827 SGTC_865 0488-0499 301 µM 0.701940816522057 0.243422369018311 no 845 0.241358036489756 1217 9634651 SGTC_609 0986-0026 86.3 µM 0.698486989050972 0.244487131209567 no 846 0.242436345935414 1178 2848610 SGTC_1150 3909-7983 10.9 µM 0.69848076011371 0.244489053759721 no 847 0.242438293008649 1197 23965914 SGTC_3070 9117005 49.47 µM 0.698436634297644 0.244502673345783 no 848 0.242452086325661 1205 8779016 SGTC_486 niguldipine 82 µM 0.69824001132238 0.244563366676621 no 849 0.242513553994294 1194 1236 A calcium channel blocker. SGTC_56 0957-0365 83.25 µM 0.69783800449105 0.244687482888786 no 850 0.242639254396698 1168 6752360 SGTC_2982 9019404 25.97 µM 0.696921512210707 0.244970568890952 no 851 0.242925957107895 1084 22333232 SGTC_2974 9094440 9.66 µM 0.692329480450595 0.24639160445662 no 852 0.244365220281209 1213 25236134 SGTC_2286 7945697 125 µM 0.689709070027614 0.247204483872669 no 853 0.245188580448613 1170 1245733 SGTC_1804 st050076 49.1 µM 0.689453363812047 0.247283883411797 no 854 0.245269005806901 1210 3895976 SGTC_1074 carmofur 3.8 µM 0.688204527942067 0.247671856247334 no 855 0.245661996475142 1245 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_495 decylubiquinone 155 µM 0.687925900627945 0.247758461059918 no 856 0.245749722595506 1177 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1617 st002906 78 µM 0.685582271732447 0.2484875630946 no 857 0.246488282027644 1219 5150859 SGTC_2434 5670830 169.91 µM 0.684659210609003 0.24877504056673 no 858 0.246779496987419 1198 1549830 SGTC_2748 diazoxide 86.69 µM 0.683237499799174 0.249218163309956 no 859 0.247228390173599 1164 3019 A potassium channel activatior. SGTC_3014 9081533 49.47 µM 0.682219110717454 0.249535835454888 no 860 0.247550206124313 1223 21367265 SGTC_307 1501-1223 22.3 µM 0.680733362685944 0.249999679274407 no 861 0.248020110931491 1211 2830329 SGTC_1424 4048-1941 275 µM 0.679155625100492 0.250492742249387 no 862 0.248519630286228 1265 X1424 SGTC_2648 atorvastatin 78.68 µM 0.678802842458572 0.250603061742717 no 863 0.248631396262319 1235 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3186 9110464 49.47 µM 0.678193566751882 0.250793650381286 no 864 0.248824485496869 1230 17018021 SGTC_3256 9138902 49.47 µM 0.676834624647979 0.251219019844784 no 865 0.249255443464087 1244 17228773 SGTC_2363 9053361 176 µM 0.676108549460633 0.251446448661239 no 866 0.249485864476445 1270 6469797 YMR079W SEC14 SGTC_1444 4112-3581 28 µM 0.675335289933688 0.25168877664227 no 867 0.249731383916343 1250 2877249 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.674824873919789 0.251848800945343 no 868 0.249893517568614 1239 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2719 novobiocin 32.65 µM 0.674490759476595 0.251953580716561 no 869 0.249999679274407 1236 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2231 micatex 6.853 µM 0.674325954058692 0.252005272897808 no 870 0.250052053450275 1242 20737 An antifungal of unknown mechanism. SGTC_1562 morin hydrate 59.1 µM 0.673496686188434 0.252265462504514 no 871 0.250315678135549 1251 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2593 nobiletin 86.24 µM 0.672707547526901 0.252513192710196 no 872 0.25056668248602 1188 72344 An anti-infammatory. SGTC_2624 nerol 100 µM 0.671995770842103 0.252736746973175 no 873 0.25079319434378 1185 637566 A natural product oil. SGTC_994 3910-0338 138 µM 0.671685965328295 0.25283408298845 no 874 0.25089181898234 1303 3479481 SGTC_1996 st072960 66.8 µM 0.670412735570199 0.253234318849608 no 875 0.251297359132297 1231 1719405 SGTC_899 1083-0020 478 µM 0.669278191977436 0.253591239637001 no 876 0.25165901773945 1277 767123 SGTC_12 0849-0099 9.267 µM 0.669082112236794 0.253652951949181 no 877 0.251721549953229 1180 6071388 SGTC_711 k292-0785 179 µM 0.668709307097661 0.253770306919093 no 878 0.251840464673085 1249 4146315 SGTC_2032 5185112 25.99 µM 0.668454899461623 0.253850408014641 no 879 0.251921630823852 1176 5718189 SGTC_2827 7993847 71.43 µM 0.666323804606091 0.254521911225035 no 880 0.252602076664656 1202 2985692 SGTC_156 3474-0145 5.642 µM 0.665400067846797 0.254813267459098 no 881 0.252897320780791 1187 2265471 SGTC_497 capsazepine 133 µM 0.664786882386994 0.255006768934884 no 882 0.253093406955101 1210 2733484 A calcium channel blocker. SGTC_797 k781-0471 270 µM 0.664096579938353 0.255224697988957 no 883 0.253314249478025 1241 23738129 SGTC_916 4466-0038 42 nM 0.663890819997287 0.255289675406331 no 884 0.253380096078636 1295 5722064 YGL116W CDC20 SGTC_2585 alliin 100 µM 0.662883517092841 0.25560789871989 no 885 0.253702579530146 1327 87310 A garlic compound which reacts with lipids. SGTC_1649 st011737 51.3 µM 0.660315879758366 0.256419993111134 no 886 0.254525570856697 1240 1761035 SGTC_1877 wortmannin 25 µM 0.660101618192826 0.256487820654011 no 887 0.254594310164882 1249 312145 A covalent inhibitor of PI 3-kinase. SGTC_911 3456-4043 236 µM 0.660023713332558 0.256512484861347 no 888 0.254619305980793 1314 914281 SGTC_1278 0874-0585 172 µM 0.65894401639756 0.25685443755368 no 889 0.254965859623736 1253 766306 SGTC_78 0336-0123 156.75 µM 0.658193800208952 0.257092179438686 no 890 0.255206804063496 1153 6765896 SGTC_1962 st076595 64.5 µM 0.658025931906925 0.257145392204163 no 891 0.25526073406427 1277 279619 SGTC_1040 k898-0338 155 µM 0.657808596771337 0.257214294024101 no 892 0.255330564815035 1303 20969351 SGTC_2857 9024691 58.44 µM 0.656710781432157 0.257562481367362 no 893 0.255683450341775 1278 16478292 SGTC_1727 st034309 9.9045 µM 0.65634681403695 0.257677972677524 no 894 0.255800501457104 1295 870305 SGTC_1876 myriocin 605 nM 0.654671636284804 0.258209873527975 no 895 0.256339595367913 1305 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1919 st067113 52.3 µM 0.652706439252558 0.258834585738904 no 896 0.256972775205704 1270 1268243 SGTC_1602 st001878 87.6 µM 0.650225576727208 0.259624337083609 no 897 0.25777326109953 1290 595405 YLR310C CDC25 SGTC_2662 daunorubicin 22.37 µM 0.650050675446743 0.259680061609267 no 898 0.25782974430681 1226 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1870 st057514 26.5 µM 0.648448348225613 0.26019085922009 no 899 0.25834750404318 1272 5393161 SGTC_1826 st055655 41.6 µM 0.6475682561251 0.260471639396875 no 900 0.258632117119212 1311 676168 SGTC_1496 4469-0713 57.4 µM 0.647317204320263 0.260551762301459 no 901 0.258713334537282 1251 746691 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.646217133500257 0.260902998241741 no 902 0.259069372510182 1229 6708514 SGTC_912 3474-0017 2.18 µM 0.64618167595209 0.260914323349213 no 903 0.259080852560639 1328 3360550 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.64592525498944 0.260996231487821 no 904 0.259163881515805 1238 390807 SGTC_2371 9071574 200 µM 0.644788196103228 0.261359599625236 no 905 0.259532226172522 1252 45596039 SGTC_770 0389-1121 67.2 µM 0.643051945322689 0.26191495146251 no 906 0.260095197223818 1357 6753108 SGTC_2570 licareol 100 µM 0.643015910095317 0.261926483985981 no 907 0.260106888140037 1243 443158 SGTC_530 4358-1714 28 µM 0.64171783892513 0.262342085368705 no 908 0.260528202204215 1311 1564641 SGTC_2871 9038510 12.99 µM 0.641257671371127 0.262489497523492 no 909 0.260677642785256 1299 4945164 SGTC_1148 3909-7663 27.7 µM 0.639803133050247 0.262955729587025 no 910 0.261150297740486 1341 4084526 SGTC_975 1335-0046 28.5 µM 0.637035025074266 0.263844176107083 no 911 0.262051014766804 1240 16486740 SGTC_2536 dehydroabietamide 32.04 µM 0.635528701862119 0.264328284869091 no 912 0.262541826739739 1338 3983547 SGTC_676 falcarinol 140 µM 0.635361823830339 0.264381944674667 no 913 0.262596230285002 1352 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_416 estradiol valerate 100 µM 0.634685177617431 0.264599577781006 no 914 0.26281688135563 1283 13791 A steroid. SGTC_2872 9044037 25.97 µM 0.63405556273519 0.264802165785922 no 915 0.263022280864845 1297 6465195 SGTC_1018 4259-0013 28.1 µM 0.633948579338625 0.264836597130138 no 916 0.263057190253314 1294 6801262 SGTC_779 1360-0071 233 µM 0.633833205704986 0.264873731323573 no 917 0.263094840085034 1379 7566 SGTC_1924 st058459 75.1 µM 0.631371511753095 0.265666683045217 no 918 0.263898819313408 1254 688683 SGTC_2580 diallyl disulphide 81.36 µM 0.627778488854411 0.266826210912701 no 919 0.265074529857072 1316 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3193 9111931 49.47 µM 0.627238265892724 0.267000770680425 no 920 0.265251531678653 1351 17087244 SGTC_2250 alverine citrate 130 µM 0.627054414611673 0.267060190852581 no 921 0.26531178347432 1237 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_487 nimodipine 119 µM 0.626415682013957 0.267266679158113 no 922 0.265521163089073 1208 4497 L-type voltage-gated calcium channels inhibitor SGTC_536 3852-0578 10.6 µM 0.621981303554874 0.268702434513303 no 923 0.266977080971761 1349 2869208 SGTC_2252 omeprazole 400 µM 0.621447501514303 0.268875528961559 no 924 0.267152613104739 1267 4594 A proton pump inhibitor. SGTC_1175 0741-0056 27.6 µM 0.62034237279792 0.269234063727173 no 925 0.267516201798523 1368 765927 SGTC_3182 9108849 49.47 µM 0.620203906675166 0.269279002922571 no 926 0.267561774905215 1319 17133045 SGTC_327 1273-0057 3.96 µM 0.6197048401401 0.269441006229784 no 927 0.267726064250127 1258 3108138 SGTC_2199 6590217 200 µM 0.619084826482112 0.269642338530653 no 928 0.26793023935522 1293 703109 SGTC_1937 st074714 47.2 µM 0.617866284124178 0.270038245972413 no 929 0.268331742777529 1268 17250970 SGTC_2931 9014674 55.67 µM 0.617729260758985 0.270082783389703 no 930 0.268376910190851 1293 2996810 SGTC_756 0508-1999 28.3 µM 0.617627782539475 0.270115769751771 no 931 0.268410363217921 1263 6753853 SGTC_3220 9131269 49.47 µM 0.617483152721891 0.270162786392129 no 932 0.268458045104251 1350 17722206 SGTC_3344 9148862 3.898 µM 0.616917111967795 0.27034683575394 no 933 0.26864469964565 1363 4905352 SGTC_3111 9122088 49.47 µM 0.6158585316167 0.270691203546314 no 934 0.268993946315328 1231 16876704 SGTC_1921 5740136 50 µM 0.615705464318199 0.270741016136585 no 935 0.269044465108842 1348 1774243 SGTC_723 4182-0001 115 µM 0.615341784794259 0.270859386476261 no 936 0.269164514091495 1277 744821 YLR208W SEC13 SGTC_2786 7743617 45.45 µM 0.613729364673648 0.271384507578478 no 937 0.269697090257927 1248 583674 SGTC_324 1315-0088 19.6 µM 0.613237939801053 0.271544652011579 no 938 0.269859510885921 1268 6787421 SGTC_2241 6772625 37.8075 µM 0.612646881926045 0.271737326947291 no 939 0.270054926021888 1252 2285411 SGTC_577 r071-0003 38.6 µM 0.611836220703033 0.27200169950176 no 940 0.270323061355833 1343 4568517 YMR134W ERG29 SGTC_986 1493-0483 84 µM 0.61112727560724 0.272233005226655 no 941 0.270557661974685 1283 40079 SGTC_2804 7954240 19.48 µM 0.610471187926822 0.272447152350978 no 942 0.270774861856509 1336 828705 SGTC_1461 k072-0203 53.8 µM 0.610236913696967 0.272523639761988 no 943 0.27085244015918 1267 5418714 SGTC_1895 st058434 18.3 µM 0.609251331090674 0.272845536063291 no 944 0.271178930524322 1331 5393175 SGTC_1084 voriconazole 435 nM 0.605260631643095 0.274150843454946 no 945 0.27250291753944 1339 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_331 k048-0133 24.5 µM 0.601458037595131 0.275397487244643 no 946 0.273767476379526 1316 6813582 SGTC_391 gliotoxin 8.33 µM 0.599862746050076 0.275921317470254 no 947 0.274298856026191 1400 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_3058 9093861 49.47 µM 0.597518550992191 0.276691944697024 no 948 0.275080612624423 1358 17217477 SGTC_1263 0774-1208 64.8 µM 0.594457911544838 0.277699679512654 no 949 0.27610294237613 1398 906585 SGTC_1678 st019265 80.2 µM 0.592725287592734 0.278270950414497 no 950 0.2766825075754 1406 5367020 SGTC_104 0074-0074 590.992 µM 0.591809263435794 0.278573208033641 no 951 0.276989159686918 1224 3943124 SGTC_1911 st060208 74.3 µM 0.591545282461089 0.278660342679454 no 952 0.277077561944032 1413 688783 SGTC_377 3970-0964 33.1 µM 0.590305541208415 0.279069732975646 no 953 0.277492912540177 1386 16481235 SGTC_2891 9063876 19.48 µM 0.588821429668663 0.279560204105431 no 954 0.277990534383443 1335 6472478 SGTC_2001 4023502 57.655 µM 0.587010911347942 0.280159112687302 no 955 0.278598189278471 1392 108941 YCR052W RSC6 SGTC_933 2914-0560 114 µM 0.586635530118477 0.280283364311104 no 956 0.278724257454249 1405 463887 SGTC_853 0419-0306 21 µM 0.586064934934226 0.280472283086306 no 957 0.2789159395329 1310 762713 SGTC_1659 st012954 42.1 µM 0.581951114529004 0.281836151990812 no 958 0.280299804729861 1363 24207262 SGTC_2822 7994718 71.43 µM 0.581138649744794 0.282105888663483 no 959 0.280573505873472 1374 1018011 SGTC_1880 MG-132 525 µM 0.580762744770494 0.282230730401619 no 960 0.280700183563918 1349 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2544 sphondin 68.51 µM 0.579774251729172 0.282559145490967 no 961 0.281033431670614 1403 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2733 amorolfine 100 µM 0.57900670211877 0.282814281394001 no 962 0.281292325461668 1412 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1744 st037937 38.9 µM 0.577300105827769 0.283381955588058 no 963 0.281868371105037 1421 1016152 SGTC_1701 st028638 40.4 µM 0.57710001296568 0.283448549304501 no 964 0.281935947793654 1427 3490878 SGTC_976 1348-1067 47.6 µM 0.577099917191968 0.283448581181134 no 965 0.281935980140856 1393 5310671 YGL099W LSG1 SGTC_112 phenothiazine 287.218 µM 0.575827874392951 0.283872110254227 no 966 0.282365765320041 1392 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_656 4090-1979 187 µM 0.575759813797202 0.283894779693853 no 967 0.28238876983763 1403 22330961 SGTC_3118 9124250 49.47 µM 0.574779744471001 0.284221314576879 no 968 0.282720133712299 1322 1504786 SGTC_398 bronopol 33.3 µM 0.57362707632727 0.284605584753283 no 969 0.283110092597278 1375 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2323 6148992 148.28 µM 0.571727239031946 0.28523948293662 no 970 0.283753388834817 1344 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_599 1935-0052 86.5 µM 0.569531510545969 0.285972944911486 no 971 0.284497746419806 1355 9557311 SGTC_270 tamoxifen 5.46 µM 0.568754273609567 0.286232788082606 no 972 0.28476145506455 1485 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_199 4063-0024 41.6 µM 0.568723834329278 0.286242966718886 no 973 0.284771785178356 1422 306215 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.56819597011483 0.286419507349758 no 974 0.284950953768999 1412 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_512 prima-1 270 µM 0.566475147227667 0.286995383496636 no 975 0.285535411489151 1455 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2402 5553605 200 µM 0.56618222580215 0.287093464719879 no 976 0.285634955689938 1450 6758546 SGTC_348 k064-0012 10.7 µM 0.565879821566439 0.287194737796042 no 977 0.285737739777985 1335 5066323 SGTC_3050 9093513 49.47 µM 0.565277166799583 0.287396613101653 no 978 0.285942628384129 1375 25236664 SGTC_3225 9130819 49.47 µM 0.56515811100607 0.287436501957142 no 979 0.285983112844787 1420 4547121 SGTC_695 3505-6186 243 µM 0.564633503348906 0.287612299461908 no 980 0.286161536085733 1420 1819379 SGTC_1755 st041960 45.185 µM 0.560873373755817 0.288873814635421 no 981 0.287441931273863 1403 2257073 SGTC_1210 3013-0140 750 nM 0.560583395807451 0.28897120965844 no 982 0.287540786674581 1487 905973 SGTC_2132 5317594 122.667 µM 0.557321706337316 0.290067777494112 no 983 0.288653823867269 1437 794577 SGTC_1500 4488-1866 171 µM 0.557005022321464 0.290174349274043 no 984 0.288761998883696 1490 2900003 SGTC_2182 6325192 200 µM 0.555903251026521 0.290545264654277 no 985 0.289138497834525 1355 736248 SGTC_282 k297-0036 65.7 µM 0.555423390582301 0.290706880775291 no 986 0.289302548598693 1423 5061378 SGTC_891 0929-0073 133 µM 0.554893277384317 0.290885470796003 no 987 0.289483830200918 1466 5603632 SGTC_11 0438-0307 1.3 µM 0.554534200966654 0.291006469299606 no 988 0.289606653045016 1465 4011476 SGTC_1297 1068-0111 14.1 µM 0.55422075268496 0.291112111642371 no 989 0.289713888683973 1351 767057 SGTC_2430 5571206 200 µM 0.55397933442922 0.29119348971386 no 990 0.28979649440717 1446 1731771 SGTC_840 0245-0196 390 µM 0.551790288994603 0.291931864774706 no 991 0.290546020682326 1482 3827528 SGTC_1898 st060199 18.6 µM 0.551475238462522 0.292038204496894 no 992 0.290653968199419 1398 688866 SGTC_2769 toremifene 3.73 µM 0.550947730705431 0.292216295750702 no 993 0.290834753108858 1432 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1233 0325-0408 14.2 µM 0.550768461727158 0.292276830034063 no 994 0.290896203272232 1461 12874 SGTC_817 1391-0715 46 µM 0.549940415808947 0.29255651440022 no 995 0.291180121155341 1380 1353946 SGTC_1729 st035615 45.989 µM 0.549549373107532 0.292688637891411 no 996 0.291314245659309 1388 17385451 SGTC_249 wiskostatin 11.211 µM 0.549301069781211 0.292772547722301 no 997 0.291399426668896 1426 2775510 A n-wasp and actin depolymerizer. SGTC_952 1185-0122 232 µM 0.549289237826628 0.292776546406285 no 998 0.291403485937338 1346 678600 SGTC_49 0717-0965 32.132 µM 0.548483484862875 0.293048915367513 no 999 0.291679983091349 1488 5889349 YGL099W LSG1 SGTC_1507 4075-3230 155 µM 0.547776923592404 0.293287851207414 no 1000 0.291922542827374 1344 659771 SGTC_3169 9102970 49.47 µM 0.545379912613181 0.294099113670607 no 1001 0.292746126483209 1460 17027839 SGTC_2080 5212524 12.4 µM 0.544861903408327 0.294274568799599 no 1002 0.292924249794205 1445 260183 SGTC_1206 3978-0017 132 µM 0.544806527303838 0.294293328124769 no 1003 0.292943294468147 1481 3873677 SGTC_1352 1496-0991 99 µM 0.544736233934735 0.294317141649245 no 1004 0.292967470240992 1414 3000039 SGTC_2458 5808907 16.39 µM 0.543167496677465 0.294848819495877 no 1005 0.293507241717698 1445 2731747 SGTC_1885 st057546 99.9 µM 0.543115991117255 0.294866283310863 no 1006 0.293524971569418 1499 702008 SGTC_822 1487-0950 154 µM 0.541984890972046 0.295249921727088 no 1007 0.293914457193723 1437 1958375 SGTC_2815 7968870 71.43 µM 0.540485089500367 0.295758967591098 no 1008 0.294431270536042 1405 2977326 YHR190W ERG9 SGTC_631 k072-0230 41.5 µM 0.54039008819079 0.295791225450353 no 1009 0.294464020954827 1459 5773147 SGTC_2693 st077581 40.7 µM 0.53722516442108 0.296866803373602 no 1010 0.295556045453137 1433 25238761 SGTC_2983 9022671 12.99 µM 0.536786637070022 0.297015974998778 no 1011 0.295707501577733 1553 6405161 SGTC_3290 9121031 71.43 µM 0.536571949789933 0.297089016580772 no 1012 0.295781662072401 1396 17014854 SGTC_1726 st035556 14.5795 µM 0.536129667635945 0.29723951709119 no 1013 0.295934468723182 1524 5919439 SGTC_3329 9141233 27.5565 µM 0.535992396923943 0.297286234882962 no 1014 0.295981902555079 1508 4909101 YNL103W MET4 SGTC_2334 9017922 200 µM 0.535933523056623 0.297306272647433 no 1015 0.296002247462538 1548 3163164 SGTC_2391 6285546 200 µM 0.535833988368342 0.297340150756021 no 1016 0.296036644896795 1391 846083 SGTC_3324 9138759 60.749 µM 0.535332070624896 0.297511012773946 no 1017 0.296210126770075 1454 45595710 SGTC_1940 st075990 51.1 µM 0.535207560688414 0.297553405181587 no 1018 0.296253169360581 1514 1084979 SGTC_169 k015-0017 16.025 µM 0.532432708636869 0.298498885047069 no 1019 0.297213168107634 1510 1840002 SGTC_3289 9119912 71.43 µM 0.531715980066878 0.298743319072895 no 1020 0.29746136121526 1452 17014829 SGTC_2487 5918373 44.05 µM 0.529651416230999 0.299447928527605 no 1021 0.298176819296822 1490 2876279 SGTC_1131 3454-3128 32.3 µM 0.529268096264223 0.299578833660402 no 1022 0.298309741990468 1536 710982 SGTC_2460 5552655 174.22 µM 0.528935105587642 0.299692572205866 no 1023 0.298425234041199 1395 5401989 SGTC_3241 9133421 49.47 µM 0.52848739051075 0.299845527614866 no 1024 0.298580548326307 1450 17018221 SGTC_131 0141-0277 33.849 µM 0.528124243194788 0.299969617618647 no 1025 0.298706552688358 1496 1547771 SGTC_3053 9095903 49.47 µM 0.527558325411085 0.300163042034407 no 1026 0.29890296224536 1488 17174018 SGTC_2520 obtusaquinone 4.71 µM 0.525587207757978 0.300837188057992 no 1027 0.299587523348797 1536 5967872 SGTC_2007 4011539 71.82 µM 0.524427593640338 0.301234108892714 no 1028 0.299990584226714 1434 45595301 SGTC_1997 st073024 93.8 µM 0.523727810486417 0.301473749632319 no 1029 0.300233934836003 1421 686268 SGTC_728 3030-5151 22.5 µM 0.523642755484699 0.301502882564155 no 1030 0.300263518918258 1480 3125388 SGTC_2602 kawain 100 µM 0.522446114001456 0.301912888903968 no 1031 0.300679877902507 1418 5369129 SGTC_545 4218-0007 221 µM 0.52016503264725 0.302695150880582 no 1032 0.30147427737301 1439 2840508 SGTC_2399 5884133 200 µM 0.518922217821486 0.303121736992852 no 1033 0.301907491765103 1438 722445 SGTC_806 3966-4455 5.86 µM 0.517890690222591 0.303476004550935 no 1034 0.302267268945621 1388 714982 SGTC_43 0570-0105 72.5 µM 0.517488363744514 0.30361422956473 no 1035 0.302407644888827 1505 1114046 YDL195W SEC31 SGTC_1651 st011928 86.1 µM 0.517221619494598 0.303705888858271 no 1036 0.302500730880243 1453 720198 SGTC_2233 sulbentine 40.3845 µM 0.516780257254992 0.303857577916855 no 1037 0.302654781680372 1429 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2271 7849410 118.62 µM 0.516713194702265 0.303880629188077 no 1038 0.302678191923893 1468 972430 SGTC_273 hydroxyurea 18.1 mM 0.515586732588196 0.304267942175687 no 1039 0.303071539313047 1483 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_73 0327-0325 16.231 µM 0.51456338408846 0.304619991933853 no 1040 0.303429078742871 1472 53298 SGTC_2774 tamoxifen 10.92 µM 0.51409605905148 0.304780820144619 no 1041 0.303592416298859 1478 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1758 st042942 75.2445 µM 0.513840657812592 0.304868731498879 no 1042 0.303681699693687 1424 669317 SGTC_2508 celastrol 40.54 µM 0.50963552940633 0.306317790444893 no 1043 0.305153413850126 1423 122724 Celastrol is a natural product and antioxidant. SGTC_2082 5219693 150 µM 0.508982703268082 0.306543022624647 no 1044 0.305382174076521 1442 2834649 SGTC_730 1436-0052 41.2 µM 0.508271081510245 0.306788623202004 no 1045 0.305631623784734 1478 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1338 1486-1223 76 µM 0.507947428529453 0.306900353610254 no 1046 0.305745105968221 1535 3444526 SGTC_2452 5863136 48.41 µM 0.507490108645732 0.307058258643361 no 1047 0.305905487475378 1427 2184096 SGTC_800 3448-7362 155 µM 0.506348868501542 0.307452466149531 no 1048 0.306305881265614 1528 15991913 SGTC_3312 9133330 71.43 µM 0.504307384978368 0.308158190811662 no 1049 0.307022694352906 1550 17617324 SGTC_2395 5646831 180.19 µM 0.503739378381351 0.308354672522312 no 1050 0.307222266279418 1543 6808628 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.502811207645712 0.308675858387087 no 1051 0.3075485065473 1473 140250 A respiratory chain inhibitor. SGTC_2652 actinonin 100 µM 0.500332968701818 0.309534149524198 no 1052 0.308420321751012 1473 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1470 k295-0292 231 µM 0.497777653479879 0.310420223631158 no 1053 0.309320384093438 1544 5045612 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.497592614669866 0.310484430004848 no 1054 0.309385605113222 1515 5357218 A potent inhibitor of glutathione S-transferases. SGTC_841 0251-0215 91.2 µM 0.495732006198005 0.311130360789703 no 1055 0.310041751215773 1522 3888614 SGTC_1315 1237-0019 3.69 µM 0.494792927845897 0.311456593403725 no 1056 0.310373148497062 1553 825140 SGTC_710 3448-4187 58 µM 0.492830977080412 0.312138646098695 no 1057 0.311066010444354 1507 3946412 SGTC_3154 9100113 49.47 µM 0.491796318068135 0.312498594727102 no 1058 0.311431669831503 1442 25237525 SGTC_1207 2099-0101 141 µM 0.491716304014015 0.312526438360792 no 1059 0.311459955397176 1556 5837381 SGTC_1314 1222-0010 41.1 µM 0.490589599206524 0.312918627507126 no 1060 0.311858372067398 1505 3526027 SGTC_1079 idarubicin 2.36 µM 0.488108019181377 0.313783175100074 no 1061 0.312736665625442 1501 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_934 2950-0684 338 µM 0.488059355298885 0.313800139159695 no 1062 0.312753899652489 1605 1121253 SGTC_1147 3809-1045 12.3 µM 0.487471462494288 0.314005107633342 no 1063 0.312962130755468 1458 325925 SGTC_1706 st031321 9.9705 µM 0.487276952422381 0.314072936092434 no 1064 0.313031039190986 1566 6103185 SGTC_291 SEC14.278 35.5 µM 0.486601676490168 0.31430846326345 no 1065 0.313270317632274 1581 1068044 SGTC_358 0075-0058 9.45 µM 0.486460792015189 0.314357611412579 no 1066 0.313320248798096 1685 1069125 SGTC_1483 3453-0561 55.9 µM 0.484996556225556 0.314868611017658 no 1067 0.313839394181525 1532 4546991 SGTC_1009 4106-0057 9.87 µM 0.484587350171196 0.315011482154705 no 1068 0.313984544324006 1506 2928005 SGTC_1857 st056007 79.3 µM 0.484427208092263 0.315067402063953 no 1069 0.314041356418185 1497 619834 SGTC_3134 9127454 49.47 µM 0.4831328102967 0.315519547495854 no 1070 0.314500719400152 1560 24262820 SGTC_3157 9099274 49.47 µM 0.482499490312769 0.315740872898867 no 1071 0.314725580198052 1513 17217662 SGTC_1101 ebselen 5.29 µM 0.482027160321968 0.315905980396637 no 1072 0.314893326105118 1622 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1426 4048-4480 71.7 µM 0.481736823350852 0.316007488713425 no 1073 0.314996456953523 1579 14224343 SGTC_2219 9098279 200 µM 0.481548515854566 0.316073332655038 no 1074 0.3150633535359 1558 902349 SGTC_596 1155-0152 116 µM 0.479533296464643 0.316778342894459 no 1075 0.315779643385011 1499 280313 SGTC_2010 4012422 159 µM 0.479116800648829 0.316924134131999 no 1076 0.315927769142486 1559 952393 SGTC_3057 9095946 49.47 µM 0.479077914852148 0.316937747265021 no 1077 0.315941600293771 1535 24540043 SGTC_121 0557-0495 61.343 µM 0.476821490733602 0.317728099740013 no 1078 0.316744620546268 1561 3104427 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.475726230465377 0.318112033947584 no 1079 0.317134715560189 1583 5377381 SGTC_1670 st016595 4.04 µM 0.475698929787693 0.318121606468148 no 1080 0.317144441745479 1507 597879 SGTC_1141 3253-0389 52.6 µM 0.475340564520358 0.318247272446073 no 1081 0.317272125266949 1527 5402031 SGTC_2360 9040895 200 µM 0.473731313579261 0.318811837368822 no 1082 0.317845760263878 1484 4914414 SGTC_845 0330-0138 4.51 µM 0.472673757600612 0.319183083287804 no 1083 0.318222975881955 1601 9039800 SGTC_1282 0886-0010 32.4 µM 0.471752853827118 0.319506506405244 no 1084 0.318551603183513 1619 2836211 YNL267W PIK1 SGTC_802 4112-3352 742 µM 0.471558185922777 0.319574891728508 no 1085 0.318621089305773 1614 704594 SGTC_2238 6671620 73.2395 µM 0.471082007242368 0.319742195458237 no 1086 0.318791086733434 1444 729941 SGTC_1333 1482-0047 286 µM 0.470905528544211 0.319804209956176 no 1087 0.318854099924083 1532 3811116 SGTC_2160 5660466 132.927 µM 0.470616449878919 0.319905802891073 no 1088 0.318957329186036 1577 2859134 SGTC_571 k831-0106 44.2 µM 0.469326577422837 0.32035927631288 no 1089 0.319418110437753 1616 4783639 SGTC_2961 9083290 32.55 µM 0.468463703641372 0.320662782004293 no 1090 0.319726510715109 1548 17741490 SGTC_130 0136-0219 337.655 µM 0.468065996585023 0.320802711168739 no 1091 0.319868697441971 1557 234244 SGTC_2628 lathosterol 100 µM 0.467310854078745 0.321068470403929 no 1092 0.320138745975893 1553 6710616 SGTC_1977 st070720 65.3 µM 0.465545426720862 0.321690139304321 no 1093 0.320770456861045 1520 682188 SGTC_2649 anisomycin 9.56 µM 0.464926576989698 0.321908176348154 no 1094 0.320992018685596 1513 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_174 3553-0389 74.3 µM 0.464603884142714 0.322021893861457 no 1095 0.32110757512186 1557 738071 SGTC_2700 st077718 96.8 µM 0.463263977136448 0.322494257573772 no 1096 0.321587581578104 1526 904970 SGTC_2992 9074591 71.4286 µM 0.461881774805664 0.322981832283992 no 1097 0.322083052154009 1541 17741321 SGTC_144 4161-2749 112.381 µM 0.461228507491994 0.3232123796436 no 1098 0.322317335505494 1459 797501 YMR168C CEP3 SGTC_338 4055-0136 114 µM 0.460781831336145 0.323370057136635 no 1099 0.322477569053443 1497 2900563 SGTC_2170 morpholine 200 µM 0.459674533496929 0.32376107205522 no 1100 0.322874925760569 1608 121171 Reacts with secondary amines. SGTC_1302 1159-0335 255 µM 0.459508239262337 0.32381981158039 no 1101 0.322934618360684 1516 649284 SGTC_1478 0453-0656 35.7 µM 0.456519822440622 0.324876146327833 no 1102 0.324008109949081 1563 5258496 SGTC_2103 5378138 10 µM 0.454894328942094 0.325451312380588 no 1103 0.324592631499582 1593 244142 SGTC_1664 st014217 9.02 µM 0.453788137511231 0.325842966074118 no 1104 0.324990661228909 1601 3982782 SGTC_3144 9087057 49.47 µM 0.453724495741789 0.32586550467629 no 1105 0.325013566889703 1678 17249618 SGTC_838 0109-0203 71.4 µM 0.453198914094812 0.326051662661412 no 1106 0.325202757163265 1538 759422 SGTC_1472 k841-0093 193 µM 0.453159917839294 0.326065476638508 no 1107 0.325216796193216 1618 X1472 SGTC_2088 5278280 127.392 µM 0.451032230839894 0.326819546771767 no 1108 0.325983159723211 1578 791502 SGTC_1342 1486-1464 234 µM 0.450782408131238 0.326908132530562 no 1109 0.326073190741647 1541 3253938 SGTC_992 3909-8734 162 µM 0.444226768989295 0.329236200225685 no 1110 0.328439320183659 1541 4288319 SGTC_2572 astragaloside iv 100 µM 0.443844620851259 0.329372115950155 no 1111 0.328577462708661 1582 45006101 An anti-inflammatory agent. SGTC_752 1896-0090 130 µM 0.443737221894195 0.329410317780935 no 1112 0.328616290518827 1565 772567 SGTC_2030 5175110 200 µM 0.443299128801246 0.329566166025521 no 1113 0.3287746929303 1616 2831986 SGTC_3314 9135860 59.4275 µM 0.44279490627262 0.329745575952736 no 1114 0.328957044007414 1607 25252478 SGTC_760 0568-0725 82.9 µM 0.442217083242212 0.32995122221802 no 1115 0.329166062624285 1680 3916171 SGTC_3067 9117431 49.47 µM 0.441671215503032 0.330145542866219 no 1116 0.329363570972262 1570 17150885 SGTC_1383 3049-0032 20.7 µM 0.441528347401293 0.330196409315698 no 1117 0.329415272023865 1669 712864 SGTC_3035 9091303 49.47 µM 0.441238662657242 0.330299557677371 no 1118 0.329520113033317 1563 25237002 SGTC_614 0462-0418 107 µM 0.44001988039683 0.330733671997205 no 1119 0.329961354306914 1490 5188303 SGTC_2085 5307070 144.047 µM 0.439064399662704 0.331074161064534 no 1120 0.330307436877541 1518 2840351 SGTC_2254 7938975 95.19 µM 0.437987814407531 0.331457973606844 no 1121 0.330697558430498 1676 2969277 SGTC_820 1582-0060 59.9 µM 0.436151789167296 0.332112941803856 no 1122 0.331363302066723 1540 3848840 SGTC_1831 st055328 12 µM 0.435163874275938 0.332465574759439 no 1123 0.331721741289034 1665 1103068 SGTC_2678 equilin 100 µM 0.434585364397142 0.332672140832531 no 1124 0.331931710123264 1666 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2415 st077333 57.7 µM 0.434039568474242 0.332867072456987 no 1125 0.332129853904648 1821 2766255 SGTC_501 nsc-95397 161 µM 0.433884431880022 0.332922487913768 no 1126 0.332186182704052 1644 262093 SGTC_1788 fluconazole 20 µM 0.433749284928686 0.33297076595875 no 1127 0.332235256521728 1542 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_812 4251-0442 148 µM 0.43272308085038 0.333337443325472 no 1128 0.332607979906505 1587 5723007 SGTC_449 xestospongin c 11.1929 µM 0.432197092420313 0.33352544828499 no 1129 0.332799086205138 1641 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1093 fluphenazine 7.97 µM 0.431955029142343 0.333611983437368 no 1130 0.332887049161449 1615 6602611 An atypical antipsychotic. SGTC_3048 9093155 49.47 µM 0.431627027497356 0.333729254803989 no 1131 0.333006255787487 1584 25236002 SGTC_404 fumagillin 50 µM 0.430857895530387 0.334004308448038 no 1132 0.333285849907391 1595 12015870 A methionine aminopeptidase binder. SGTC_533 1222-0222 6.71 µM 0.430636677139544 0.334083436133591 no 1133 0.333366284171847 1679 3982874 SGTC_2289 7946404 165.07 µM 0.430013489966456 0.334306383822658 no 1134 0.33359291412542 1556 1246120 YPR165W RHO1 SGTC_3313 9133968 57.047 µM 0.429973280975901 0.334320770757454 no 1135 0.333607538723736 1564 1494643 SGTC_3074 9116018 49.47 µM 0.428332423296054 0.334908083485308 no 1136 0.334204558148201 1616 17027303 SGTC_1035 k081-0041 55.2 µM 0.428250126505261 0.334937550653557 no 1137 0.334234512567555 1649 731709 SGTC_949 1165-0505 146 µM 0.428026350672543 0.335017680909943 no 1138 0.334315967923749 1565 6244267 SGTC_1882 5615643 20 µM 0.427226284595818 0.335304232143238 no 1139 0.334607259175394 1551 2253075 SGTC_429 1112-0049 25.5 µM 0.424849180742766 0.336156179313952 no 1140 0.335473311524866 1526 2836170 SGTC_1440 4100-1550 40 µM 0.422227721410481 0.337096679358008 no 1141 0.336429404593843 1596 742806 SGTC_2807 7945238 51.95 µM 0.420820490831552 0.337601971772907 no 1142 0.336943083840255 1629 17148797 SGTC_1710 st031758 61.5 µM 0.419822232702861 0.337960592651136 no 1143 0.337307661030002 1670 5394341 SGTC_237 nikkomycin 200 µM 0.41730900735837 0.338864111259245 no 1144 0.338226200490492 1672 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3119 9125183 49.47 µM 0.414696157310211 0.339804429354676 no 1145 0.339182172882837 1605 22695334 SGTC_568 1193-0097 7.48 µM 0.413546210338342 0.340218591287542 no 1146 0.339603236677124 1596 3646150 SGTC_514 4466-0038 2.65 nM 0.412255218658114 0.340683781280842 no 1147 0.340076183924989 1649 5722064 SGTC_2746 daunorubicin 9.88 µM 0.409276796053528 0.341757936190392 no 1148 0.341168271025147 1681 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1518 st038567 90.8 µM 0.409100437644149 0.341821579370134 no 1149 0.341232977556515 1592 77966 SGTC_1409 3909-8004 61.9 µM 0.406116511517859 0.342899081249716 no 1150 0.342328497131678 1634 2119279 SGTC_1112 tnp00069 1.16933 µM 0.405548368606703 0.343104384042299 no 1151 0.342537236088751 1711 145826 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.403289209466493 0.343921206308444 no 1152 0.343367739446122 1690 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2076 5212012 200 µM 0.400724072591964 0.34484954168862 no 1153 0.344311642709627 1620 604802 SGTC_102 gallobenzophenone 83.616 µM 0.399217320561552 0.345395278730668 no 1154 0.344866540951067 1721 70837 SGTC_423 5-fluorouracil 457 µM 0.397749986043329 0.345927048073147 no 1155 0.345407243635593 1526 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1619 st003326 88.7 µM 0.397711635914373 0.345940950432408 no 1156 0.34542137963168 1708 2849032 SGTC_810 3825-7150 143 µM 0.397522713425137 0.346009440021343 no 1157 0.345491020290681 1797 22330411 YGL099W LSG1 SGTC_1043 0916-0009 19.3 µM 0.397512235720741 0.34601323862431 no 1158 0.345494882738004 1811 3101130 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.397260392646204 0.346104546859255 no 1159 0.345587725719633 1765 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2275 7947463 200 µM 0.397004849325122 0.346197205801769 no 1160 0.345681942307171 1654 1225414 SGTC_606 k015-0008 38.6 µM 0.395692772295667 0.346673104363901 no 1161 0.346165844059798 1750 1970475 SGTC_1025 k007-0731 70 µM 0.395083657678954 0.346894116369222 no 1162 0.346390574578169 1606 6256118 SGTC_1111 tnp00062 510.699 nM 0.394737314231146 0.34701980735392 no 1163 0.346518380799769 1753 676306 SGTC_1906 st060206 94.7 µM 0.393831768666964 0.347348517057413 no 1164 0.346852624003721 1737 5133468 SGTC_295 k015-0027 31 µM 0.393398475375684 0.347505841565377 no 1165 0.347012597775244 1628 3887424 SGTC_122 0236-0016 402.397 µM 0.392015093921082 0.34800830940784 no 1166 0.34752353063947 1664 6808838 SGTC_2299 7976368 114.88 µM 0.391400337310547 0.34823168527995 no 1167 0.347750671514645 1743 2979718 SGTC_737 1950-0117 57.9 µM 0.39060410362796 0.348521080307026 no 1168 0.348044945951333 1722 5393513 SGTC_2342 7990637 118.86 µM 0.3903938722408 0.348597504655792 no 1169 0.34812265918056 1673 2033102 YER133W GLC7 SGTC_744 1594-0068 283 µM 0.389075745410862 0.349076816552703 no 1170 0.348610057520051 1638 668392 SGTC_3138 9097216 49.47 µM 0.388948475631774 0.349123108564683 no 1171 0.348657130790492 1637 25237486 SGTC_2210 7115885 190.385 µM 0.386853832825592 0.349885317973359 no 1172 0.349432210580064 1662 2927039 SGTC_1909 st060837 51.5 µM 0.384695990703372 0.350671157726226 no 1173 0.350231332995006 1619 678937 SGTC_1930 st074634 34.3 µM 0.383179142053164 0.351223944356274 no 1174 0.350793471102653 1564 684253 YOR116C RPO31 SGTC_759 3486-0358 89.3 µM 0.382028455686248 0.351643500242646 no 1175 0.351220128980979 1817 875103 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.381550698289019 0.351817750220248 no 1176 0.351397329662567 1680 65057 A dermal irritant. YDR527W RBA50 SGTC_2455 5377712 9.75 µM 0.381400665805162 0.35187247721472 no 1177 0.35145298352314 1577 2243908 SGTC_1209 2323-2347 50.3 µM 0.38089023499166 0.352058688832231 no 1178 0.351642349330261 1711 5412760 SGTC_751 0833-0568 350 µM 0.380623465344863 0.352156023894952 no 1179 0.351741333418734 1689 6954252 SGTC_1122 capsaicin 818.572 nM 0.380550552569242 0.352182628943123 no 1180 0.351768389237757 1729 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1627 st003713 25.6 µM 0.380232371879816 0.352298737948188 no 1181 0.351886465659659 1640 16195070 YER133W GLC7 SGTC_1713 st033146 12.748 µM 0.380062297861676 0.352360806208316 no 1182 0.3519495857565 1772 674619 SGTC_2121 5257820 149.641 µM 0.379991208972588 0.3523867511581 no 1183 0.351975970405215 1791 791256 SGTC_1462 k081-0014 26.5 µM 0.376033468623614 0.353832267998084 no 1184 0.353446007281985 1566 3270634 SGTC_941 3237-0776 460 µM 0.374917232123967 0.354240342220342 no 1185 0.353861011461195 1760 760008 SGTC_2211 7117706 200 µM 0.373900697551448 0.354612113053173 no 1186 0.354239098729355 1742 822771 SGTC_2283 7944793 200 µM 0.373623379809603 0.354713558803644 no 1187 0.354342268548954 1593 2970533 SGTC_314 1671-0008 2.74 µM 0.373176892180564 0.354876910328313 no 1188 0.354508396673004 1672 3913060 SGTC_546 peri-Naphthalide 147 µM 0.373038795838727 0.354927439524247 no 1189 0.354559784859191 1756 223824 A penicillin ester. SGTC_611 3453-1652 23.7 µM 0.37298075981204 0.354948675560634 no 1190 0.354581381921192 1749 1560575 SGTC_2962 9082311 13.18 µM 0.372961762472978 0.354955626999049 no 1191 0.354588451540314 1602 16459453 SGTC_2378 9074213 121.43 µM 0.371511297068117 0.35548651853924 no 1192 0.355128371619457 1655 657714 SGTC_956 1185-0240 191 µM 0.368486208539563 0.356594646753404 no 1193 0.35625536341582 1686 1416193 SGTC_784 4579-0127 173 µM 0.366734076358879 0.35723702969198 no 1194 0.356908692828146 1805 1948547 SGTC_3078 9116413 49.47 µM 0.364860216965308 0.357924489395073 no 1195 0.35760787616595 1633 17177322 SGTC_109 0132-0036 33.701 µM 0.364600847471411 0.358019680224978 no 1196 0.357704691069644 1705 67274 A color developer. SGTC_1445 4239-0156 97.7 µM 0.361126551681661 0.359295625588292 no 1197 0.359002422654909 1808 4008346 SGTC_2656 pseudo-anisatin 100 µM 0.360559789539907 0.359503920047415 no 1198 0.359214276636418 1712 6708809 A neurotoxin. SGTC_1030 k029-0042 36.7 µM 0.360080625642557 0.359680053276946 no 1199 0.359393420436729 1698 6080581 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.358696623557776 0.360188958289982 no 1200 0.35991102727162 1872 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_875 0709-0210 25.7 µM 0.356147896461189 0.361126786896648 no 1201 0.360864904746771 1766 6251364 SGTC_522 1273-0010 11.6 µM 0.354486048532251 0.361738730098327 no 1202 0.361487328890328 1731 5705015 SGTC_413 propylparaben 100 µM 0.354152531397548 0.361861583970821 no 1203 0.361612287758131 1648 7175 A pharmaceutical preservative. SGTC_1344 1488-0097 29.1 µM 0.354151137151082 0.361862097583254 no 1204 0.361612810171457 1725 747966 SGTC_662 k832-1615 104 µM 0.353505888664086 0.362099820871914 no 1205 0.361854607438873 1748 5878478 SGTC_1786 berberine 21.6 µM 0.353345229175304 0.362159019526514 no 1206 0.361914820771606 1637 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2600 tangeritin 87.95 µM 0.350979474280853 0.363031116964141 no 1207 0.362801873605991 1613 68077 A bioactive flavone. SGTC_3102 9121669 49.47 µM 0.349707990006375 0.363500123102654 no 1208 0.363278928353745 1751 41905072 SGTC_336 4111-0029 111 µM 0.349115006656178 0.363718923975678 no 1209 0.363501485426998 1669 3131175 SGTC_663 1486-0733 13.9 µM 0.348803917485346 0.363833728424185 no 1210 0.36361826109236 1716 722445 YPR165W RHO1 SGTC_2642 cholecalciferol 100 µM 0.347330742949403 0.364377555095102 no 1211 0.364171428594978 1769 9821465 A vitamin D precursor, similar to steriods. SGTC_2690 usnic acid 100 µM 0.346679632168508 0.364618001637818 no 1212 0.364416006759529 1833 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_421 streptovitacin 30 mM 0.345079897831509 0.36520898828043 no 1213 0.365017152752665 1689 91467 include heat shock SGTC_2094 5332512 191.667 µM 0.344969359402776 0.365249836115072 no 1214 0.365058703009433 1800 755774 SGTC_735 3076-0345 636 µM 0.344682716646871 0.365355767809638 no 1215 0.365166456449301 1806 2888990 SGTC_2938 9059746 27.26 µM 0.343520788021367 0.365785275285992 no 1216 0.365603352335887 1742 6471769 SGTC_1266 0828-0227 32.9 µM 0.342981662897721 0.365984620340635 no 1217 0.365806127629623 1783 3913820 SGTC_2998 9066762 71.4286 µM 0.341992465314171 0.366350476711847 no 1218 0.366178281287977 1813 4945196 SGTC_1806 st050005 60.3 µM 0.341765695434649 0.366434365061024 no 1219 0.366263613888555 1683 5194765 SGTC_1709 st033179 39.1045 µM 0.341662676585728 0.366472476645024 no 1220 0.366302381655195 1691 573381 SGTC_1161 k007-0610 110 µM 0.338964665368626 0.367471067434481 no 1221 0.367318174480875 1767 5843850 SGTC_2375 9072683 200 µM 0.338450901481607 0.367661324127381 no 1222 0.367511710525436 1879 16798029 SGTC_373 0844-0104 25.9 µM 0.338448160097198 0.36766233940215 no 1223 0.367512743301594 1829 5375804 SGTC_1004 4084-0029 199 µM 0.336960357198692 0.368213485139442 no 1224 0.368073392305297 1842 716894 YLR208W SEC13 SGTC_235 0330-0087 5 mM 0.336151523600602 0.368513225575137 no 1225 0.368378303234825 1718 46494818 YHR062C RPP1 SGTC_586 0957-0265 8.15 µM 0.335626749100391 0.368707741195299 no 1226 0.368576175035087 1805 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3098 9119039 49.47 µM 0.335463695403973 0.368768186371227 no 1227 0.368637663262983 1719 17161528 SGTC_1226 3909-7979 35.4 µM 0.334780890405689 0.369021342333811 no 1228 0.3688951883872 1835 6615510 SGTC_1711 st032263 62.8 µM 0.334688779381651 0.369055497659221 no 1229 0.368929933273145 1762 3958979 SGTC_1932 st074806 40.9 µM 0.334543853740198 0.369109239057652 no 1230 0.3689846023496 1783 17251235 SGTC_591 4299-0174 154 µM 0.334322372240174 0.369191373880273 no 1231 0.369068155066779 1775 5509088 SGTC_223 busulfan 5 mM 0.33196253525278 0.370066872593417 no 1232 0.369958774431196 1790 2478 A DNA alkylator. SGTC_1003 4049-0218 100 µM 0.331393462009739 0.370278099566793 no 1233 0.370173651363346 1800 295161 SGTC_2731 amoxapine 43.43 µM 0.331142002668137 0.370371447991067 no 1234 0.370268613060463 1832 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1993 st073995 70.8 µM 0.330997508957862 0.370425091369972 no 1235 0.370323183582827 1758 3098394 SGTC_3269 9137823 49.47 µM 0.329367440954564 0.371030429446568 no 1236 0.370938987223461 1702 17682936 SGTC_2327 6189656 200 µM 0.32899721375279 0.371167960662553 no 1237 0.371078897010332 1838 5349088 SGTC_2947 9072639 7.68 µM 0.326925011015783 0.371938041479039 no 1238 0.371862301777265 1671 16488146 SGTC_1375 2910-0797 186 µM 0.326661986850499 0.372035824364606 no 1239 0.371961777177514 1747 742508 SGTC_1973 st070275 50.2 µM 0.326535692415828 0.372082779007601 no 1240 0.372009544607643 1817 17118334 SGTC_1685 st024049 53.0905 µM 0.324105907177305 0.372986511421805 no 1241 0.372928927419891 1764 1941139 SGTC_362 0310-0100 9.03 µM 0.323541702007145 0.373196461687862 no 1242 0.373142515326596 1724 790235 SGTC_2892 9047358 58.44 µM 0.323225013991577 0.373314323147645 no 1243 0.373262419177144 1732 6466771 SGTC_683 panaxydol 45 µM 0.322660484700669 0.373524452838216 no 1244 0.373476190683161 1822 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_881 0833-0569 170 µM 0.321803341091949 0.373843571625473 no 1245 0.373800841505682 1671 5418700 SGTC_843 0310-0051 143 µM 0.321544277307055 0.373940039380883 no 1246 0.373898981870661 1764 2065037 SGTC_1946 st076057 65.1 µM 0.320340531566202 0.374388382486203 no 1247 0.374355100452697 1727 953009 SGTC_3092 9117248 49.47 µM 0.318313151422309 0.375143877497365 no 1248 0.375123704670816 1848 17141857 SGTC_2129 girgensonine 121.053 µM 0.318135503729225 0.375210100069895 no 1249 0.375191076734118 1806 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3046 9092212 49.47 µM 0.315194297934439 0.376307040504073 no 1250 0.376307067337856 1751 25236637 SGTC_2944 9067346 25.62 µM 0.314230308030166 0.376666784343342 no 1251 0.376673062581166 1791 6473075 SGTC_2374 9071832 200 µM 0.313787881928748 0.376831925758602 no 1252 0.376841074353714 1777 17381698 SGTC_641 4092-0595 30 µM 0.312965010766563 0.377139133263007 no 1253 0.377153622549768 1833 786260 SGTC_3159 9100096 49.47 µM 0.312720089290436 0.377230586319361 no 1254 0.377246665748477 1716 25236875 SGTC_224 benfluorex 43.875 µM 0.312668262197076 0.377249939307136 no 1255 0.377266355252308 1858 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_193 1273-0060 1.558 µM 0.312291938851 0.377390473142323 no 1256 0.377409332897636 1848 2847393 YHR072W ERG7 SGTC_1064 honokiol 6.76 µM 0.311949466989393 0.377518379623719 no 1257 0.37753946385324 1767 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_350 k064-0020 19.8 µM 0.310728799754674 0.377974383933001 no 1258 0.378003400629403 1884 2790705 SGTC_2372 9071633 200 µM 0.31057280549955 0.378032670931115 no 1259 0.378062701778632 1865 21321366 SGTC_2981 9013952 38.96 µM 0.310471713412973 0.378070445306515 no 1260 0.378101133426345 1644 2996344 SGTC_1108 betulinic acid 729.144 nM 0.310184595184341 0.378177737129528 no 1261 0.37821029223253 1750 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3020 9089140 49.47 µM 0.30969505413541 0.378360693019369 no 1262 0.378396432111336 1745 17217859 SGTC_2523 spermine 47.74 µM 0.307023133255876 0.379359748123254 no 1263 0.379412882123616 1904 1103 A DNA binding polyamine. SGTC_192 3455-0609 60.9 µM 0.306886259354845 0.379410948260632 no 1264 0.379464974100629 1788 3769639 SGTC_1490 4089-0339 670 nM 0.304996566287255 0.380118037637789 no 1265 0.380184383757485 1890 742542 SGTC_708 3448-5400 146 µM 0.303145179082439 0.38081118246556 no 1266 0.38088961254178 1855 3462195 SGTC_1124 fisetin 1.16336 µM 0.301373036344785 0.381475017333623 no 1267 0.381565026479135 1744 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1523 st012844 44.7 µM 0.300949227314383 0.381633825610665 no 1268 0.381726605675123 1772 4274103 SGTC_929 2805-0021 398 µM 0.300659642704992 0.381742349230713 no 1269 0.381837023030312 1782 3098024 SGTC_2882 9058044 58.44 µM 0.299492842135625 0.382179709046133 no 1270 0.382282016347951 1681 18076804 SGTC_3017 9080681 49.47 µM 0.298624575038387 0.382505265144877 no 1271 0.382613256207994 1753 16451914 SGTC_532 1548-0774 215 µM 0.298040406888332 0.382724345309091 no 1272 0.382836161991305 1900 5932993 SGTC_1939 st074455 53.6 µM 0.297184909689176 0.383045249523286 no 1273 0.383162671023236 1922 1644229 SGTC_2679 rapamycin 1 nM 0.296297069156025 0.383378370889156 no 1274 0.383501611998014 1803 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1825 st052143 62.6 µM 0.295701125020508 0.383602019929482 no 1275 0.383729168973987 1873 674173 SGTC_198 3454-2873 16.191 µM 0.294048677486147 0.384222361764635 no 1276 0.38436035370649 1806 710957 SGTC_448 monastrol 171 µM 0.293928334221469 0.384267551184425 no 1277 0.384406333178842 1842 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3274 9138298 49.47 µM 0.293294968276663 0.38450540876722 no 1278 0.384648349681735 1840 17015756 SGTC_228 caffeine 993.056 µM 0.288917407748315 0.386150565409032 no 1279 0.386322291042232 1888 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3170 9103054 49.47 µM 0.288074774115621 0.386467476586749 no 1280 0.386644750916156 1778 16432970 SGTC_1680 diphenhydramine 100 µM 0.287890371755787 0.386536839693838 no 1281 0.386715328641717 1778 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2013 4024628 200 µM 0.287807284781474 0.386568094115954 no 1282 0.386747130379482 1848 5230760 SGTC_1976 st070609 63.5 µM 0.286344923705939 0.387118303625219 no 1283 0.387306976870925 1802 682556 SGTC_1863 st057641 20.1 µM 0.285868988993306 0.387297421799007 no 1284 0.387489233100062 1957 3921635 SGTC_248 streptozotocin 5.23457 mM 0.285735094314472 0.387347817428877 no 1285 0.387540511703319 1920 5300 DNA alkylating agent. SGTC_2416 tofa 880 nM 0.285277128346036 0.387520202206362 no 1286 0.387715917033044 1677 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3013 9080133 71.4286 µM 0.285144221573027 0.387570234322813 no 1287 0.38776682588561 1847 17050193 SGTC_1245 0418-0076 17.2 µM 0.284775079374846 0.387709205922723 no 1288 0.387908232904548 1821 6790114 SGTC_479 n-linoleoylglycine 10 µM 0.284683612689537 0.38774364276811 no 1289 0.387943273276365 1801 6433346 An anti-infammatory. SGTC_2074 5212007 75.395 µM 0.283197631331115 0.388303232395322 no 1290 0.388512671994843 1939 758611 SGTC_1186 1319-0216 26 µM 0.282906310600457 0.388412964944257 no 1291 0.388624328482295 1963 4565136 SGTC_3115 9123671 49.47 µM 0.282903998406427 0.388413835920127 no 1292 0.388625214729525 1861 3286988 SGTC_1766 st045414 44.774 µM 0.281738342142314 0.388852996064351 no 1293 0.389072076057095 1802 253960 SGTC_2107 5363541 170.161 µM 0.281226016852283 0.389046059217586 no 1294 0.389268525498672 1850 244052 SGTC_1545 lovastatin 49.4 µM 0.280666656405865 0.389256878247424 no 1295 0.389483042737765 1837 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_297 0986-0032 24 µM 0.277830706765974 0.390326228227497 no 1296 0.390571159102725 1813 2847425 SGTC_862 0452-0056 10.2 µM 0.277266539798109 0.390539057629523 no 1297 0.390787725045236 1905 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_446 go6976 132 µM 0.276987311919217 0.390644407205596 no 1298 0.390894924377094 1946 3501 A protein kinase C inhibitor. SGTC_2915 7971052 15.16 µM 0.27638946782999 0.390869994123243 no 1299 0.391124472620906 1898 5741558 SGTC_399 oxolinic acid 75 µM 0.275486574472024 0.391210756109755 no 1300 0.391471219475695 1813 4628 A DNA gyrase inhibitor. SGTC_584 0986-0246 15.4 µM 0.275310010096699 0.391277403238949 no 1301 0.391539037289335 1913 53315 YDR232W HEM1 SGTC_1529 apigenin 74 µM 0.274766113288876 0.391482726095111 no 1302 0.391747967029726 1935 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_415 dibenzyl ketone 100 µM 0.273139866465675 0.392096819844053 no 1303 0.392372851209945 1937 7593 SGTC_1253 0550-0034 176 µM 0.272841886074532 0.392209370635038 no 1304 0.392487380103534 1814 5969915 SGTC_731 3966-0296 387 µM 0.269044011959025 0.393644660445781 no 1305 0.393947907113047 1826 660956 SGTC_2274 7947094 46.08 µM 0.26805487595816 0.394018712173185 no 1306 0.394328539430352 1880 2971028 SGTC_1430 4049-0248 69.1 µM 0.267746561037016 0.394135324567954 no 1307 0.394447203647206 1949 22774488 SGTC_2970 9090938 41.86 µM 0.266902992549789 0.394454431694074 no 1308 0.394771926242179 1980 17217104 SGTC_2793 7325131 81.82 µM 0.266547258165641 0.394589021005845 no 1309 0.394908884289648 1858 4176441 SGTC_260 nsc-65238 3.989 µM 0.2665279701895 0.394596318819984 no 1310 0.39491631054856 1899 3246252 SGTC_1553 gossypol 38.6 µM 0.26498811162524 0.395179060096203 no 1311 0.395509310049031 1879 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3245 9134821 49.47 µM 0.26449045962047 0.395367440821081 no 1312 0.395701007635472 1762 17014901 SGTC_2617 dihydrotanshinone i 20.83 µM 0.263799497428859 0.395629037540905 no 1313 0.395967210926867 1802 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_888 0916-0002 6.97 µM 0.263073978150359 0.395903768108888 no 1314 0.396246780067244 1910 2802138 YIL048W NEO1 SGTC_2855 9016525 58.44 µM 0.262626514997264 0.396073233654456 no 1315 0.396419230617094 1852 43811474 SGTC_3348 9149464 3.537 µM 0.262546469170442 0.39610355109358 no 1316 0.396450082103767 1895 1951442 SGTC_1114 scopoletin 1.73284 µM 0.262198721066499 0.396235268338073 no 1317 0.396584119676101 1946 5280460 A coumarin with genotoxic properties. SGTC_1693 xanthone 101.9 µM 0.261216969538089 0.396607192209878 no 1318 0.396962596250947 1896 7020 An insecticide. SGTC_1237 0330-0133 46.1 µM 0.260940672596481 0.396711880714279 no 1319 0.3970691294379 1837 X1237 YHR072W ERG7 SGTC_2134 5324836 1.464 µM 0.259843870974117 0.397127530604985 no 1320 0.39749210438894 1862 699272 SGTC_2701 st077767 14.721 µM 0.258926463236185 0.39747528620011 no 1321 0.397845989784156 1827 5721188 SGTC_1764 st044502 93.5 µM 0.258877684409359 0.397493778747076 no 1322 0.39786480832628 1848 8407 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.25840755780681 0.397672020305072 no 1323 0.398046192172124 1877 6708739 YPR165W RHO1 SGTC_85 0868-0259 160.055 µM 0.2580951049975 0.397790493993542 no 1324 0.398166754641358 1864 83173 SGTC_3270 9137563 49.47 µM 0.257627562777738 0.397967791011996 no 1325 0.398347177782968 1920 17015724 SGTC_1252 0493-0875 34.8 µM 0.257096393405124 0.3981692416956 no 1326 0.398552180821566 1813 3960963 SGTC_62 0180-0423 3.232 µM 0.256746794204653 0.398301845101745 no 1327 0.398687122741905 1910 30102 YGL099W LSG1 SGTC_2472 5377652 49.4 µM 0.256631575771062 0.398345550169124 no 1328 0.398731598600866 1828 1610903 SGTC_1348 1493-0373 93.8 µM 0.254253248535587 0.399247989812424 no 1329 0.399649957719456 1897 3010129 SGTC_1721 st082152 9.2685 µM 0.252918022888903 0.399754868274842 no 1330 0.400165780955122 1857 5296051 SGTC_2188 6126565 140.678 µM 0.252050115381817 0.400084434061005 no 1331 0.400501163727999 1947 874518 SGTC_3356 9151811 4.48 µM 0.25172661784276 0.400207292238519 no 1332 0.40062619065058 1845 1859254 YPR165W RHO1 SGTC_1565 sinapyl alcohol 95.1 µM 0.250818116706936 0.400552376371335 no 1333 0.400977367054102 1802 5280507 A phenol propionate derived from cinnamic acid. SGTC_463 ikarugamyin 104 µM 0.250556061936836 0.400651929422966 no 1334 0.401078677850479 1889 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_792 4534-1957 155 µM 0.250531993962376 0.400661073027265 no 1335 0.401087982901824 1881 1717904 SGTC_1743 st037606 46.3785 µM 0.246761186198723 0.402094300465284 no 1336 0.402546525310787 1857 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1578 josamycin 24.2 µM 0.246446629630779 0.402213918493641 no 1337 0.402668256913744 1802 5282165 A P450 substrate. SGTC_1096 rimcazole 32.2 µM 0.245136931448361 0.402712062421068 no 1338 0.403175203981099 1861 18528119 A dopamine reuptake inhibitor. SGTC_117 lucigenin 22.078 µM 0.24504037130407 0.402748795351491 no 1339 0.403212586130959 1762 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1795 st049545 62.3 µM 0.24294756747298 0.403545139800022 no 1340 0.404023007854467 2037 5291882 SGTC_1417 3966-0327 90.4 µM 0.242802474021357 0.403600364985346 no 1341 0.40407920946181 1892 651118 SGTC_967 1306-0166 352 µM 0.242058299403272 0.403883641457944 no 1342 0.404367494846309 2001 4437607 SGTC_2629 bisabolol 100 µM 0.242049372785922 0.403887039757971 no 1343 0.404370953239079 1917 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1045 1348-1485 165 µM 0.240332420967339 0.404540805755323 no 1344 0.405036281554252 1966 6810614 SGTC_1970 st070122 35.8 µM 0.239980141226349 0.40467497679725 no 1345 0.405172825911171 1968 102928 SGTC_3128 9127691 49.47 µM 0.239694807624096 0.404783658611674 no 1346 0.405283430268608 1891 41316314 SGTC_200 k038-0079 37.545 µM 0.239490315648227 0.404861552866923 no 1347 0.405362702500677 1920 3436683 SGTC_2868 9035608 32.47 µM 0.239068108057055 0.405022390396523 no 1348 0.405526385447315 1838 6462614 SGTC_221 trifluoperazine 10.304 µM 0.239053786324387 0.405027846458904 no 1349 0.405531938037668 1890 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_475 α-linolenic acid 10 µM 0.238985129689688 0.405054002410977 no 1350 0.405558556740662 1985 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1645 Cervolide 78 µM 0.238694295913574 0.405164805353661 no 1351 0.405671320064976 1872 23173 A fragrance. SGTC_1575 cyproterone acetate 48 µM 0.238450343931314 0.405257752957893 no 1352 0.405765912215809 1822 9880 An androgen receptor antagonist and liver toxin. SGTC_594 1487-1584 10.8 µM 0.236713255287037 0.40591975145646 no 1353 0.406439625475944 1808 5013332 SGTC_885 0865-0106 16.8 µM 0.236340266649669 0.406061931301377 no 1354 0.406584321761502 1817 2793380 SGTC_2324 6149169 200 µM 0.234342662731647 0.40682361000685 no 1355 0.407359483891571 1982 2888231 SGTC_2348 9022543 33.42 µM 0.233942913889882 0.406976075136715 no 1356 0.407514648492068 1906 3162678 YDL140C RPO21 SGTC_790 1575-0012 79.1 µM 0.232179518694057 0.407648806097726 no 1357 0.408199292425061 2010 378741 YLR208W SEC13 SGTC_870 0573-2213 57.6 µM 0.232172267231276 0.407651573076842 no 1358 0.40820210840934 1967 3916321 SGTC_2423 st077119 87.2 µM 0.231985887914101 0.407722692401966 no 1359 0.408274487326174 1956 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_702 1488-0190 94 µM 0.231404831379384 0.407944433662256 no 1360 0.408500156059369 2029 949357 SGTC_684 1140-0066 328 µM 0.231105099725098 0.408058827998154 no 1361 0.408616576674128 1874 6813534 SGTC_2894 9048625 32.47 µM 0.229957052718984 0.408497059259088 no 1362 0.409062571186738 2011 4092861 SGTC_2689 tacrolimus 100 µM 0.229817343761514 0.40855039663322 no 1363 0.409116853518257 1869 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_955 1216-0110 33 µM 0.229591117019422 0.408636767918419 no 1364 0.409204755049775 1847 3619719 SGTC_1907 st060210 83.7 µM 0.229404639189291 0.408707966772138 no 1365 0.409277215375894 1993 688793 SGTC_3203 9113543 49.47 µM 0.229092993230112 0.408826962627826 no 1366 0.409398319626555 1914 17018012 SGTC_2864 9034755 47.6 µM 0.227729314347554 0.40934775519164 no 1367 0.409928340798657 2055 4930451 SGTC_204 PMA1.184 62.41 µM 0.225696400016332 0.410124427388238 no 1368 0.410718779110949 1920 2252213 YGL008C PMA1 SGTC_2789 5281112 71.43 µM 0.225367076342654 0.410250278331648 no 1369 0.41084686105638 1826 765948 SGTC_441 propafenone 146 µM 0.224650896575124 0.410523998108433 no 1370 0.411125433496007 1915 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2054 5233173 129 µM 0.224321806868604 0.410649788920416 no 1371 0.411253454555702 1930 6889 SGTC_2116 5511452 16.8835 µM 0.224070048946699 0.410746026739629 no 1372 0.411351398719163 1935 870744 SGTC_1404 3909-7820 48.3 µM 0.222721622951087 0.411261571864104 no 1373 0.411876085673392 2026 23741373 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.222097352774719 0.411500301697933 no 1374 0.412119049291115 1798 641818 YHR062C RPP1 SGTC_2294 7971431 200 µM 0.220756684111686 0.412013103192559 no 1375 0.412640946266935 1981 5741572 SGTC_780 0109-0199 192 µM 0.219951589333721 0.412321121660231 no 1376 0.412954428747581 2032 610414 SGTC_1689 st020265 53.493 µM 0.219573542917233 0.412465775798235 no 1377 0.413101649128114 2032 5758320 YPR016C TIF6 SGTC_510 ag-490 170 µM 0.219547954810054 0.412475567157007 no 1378 0.4131116141952 2053 5328779 SGTC_17 0960-0276 49.807 µM 0.219517202232654 0.412487334786417 no 1379 0.413123590594627 1964 6821114 SGTC_3327 9140648 26.9345 µM 0.216521251154479 0.413634126186085 no 1380 0.414290730995681 2013 8029710 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.216372697919667 0.413691008714576 no 1381 0.414348623053071 1905 688788 SGTC_755 1995-0008 37.3 µM 0.215097777722984 0.41417926284079 no 1382 0.414845543238548 2023 689533 SGTC_1629 st005085 44.9 µM 0.21321358972654 0.41490108998364 no 1383 0.415580184450611 1868 24207091 SGTC_1615 st002656 86.5 µM 0.212892709107382 0.415024047156638 no 1384 0.415705324660961 1947 1584458 SGTC_3130 9127414 49.47 µM 0.212489381196016 0.415178608838007 no 1385 0.415862630609664 2072 1494646 SGTC_1329 1447-1697 50.6 µM 0.210973612291908 0.415759592818874 no 1386 0.416453931127543 1948 2840515 SGTC_2478 5763493 32.33 µM 0.210274244755114 0.416027717842723 no 1387 0.416726817812458 1964 1365576 YLR208W SEC13 SGTC_3140 9094243 49.47 µM 0.209241804576463 0.416423608381851 no 1388 0.417129739651232 2107 19291112 SGTC_2533 agelasine 13.65 µM 0.208666678571053 0.416644178003164 no 1389 0.417354227071845 2065 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_124 0136-0217 7.121 µM 0.207725117524799 0.417005337695981 no 1390 0.417721802245107 2096 3976905 SGTC_1956 st077085 54 µM 0.207013394189185 0.417278383792735 no 1391 0.417999699012602 1907 24208685 SGTC_2189 6047310 154.431 µM 0.205412490450927 0.417892701365004 no 1392 0.418624931187717 1937 711535 SGTC_673 1082-0474 110 µM 0.205187432458588 0.417979079360209 no 1393 0.41871284399882 1910 3098046 SGTC_2223 6903751 107.57 µM 0.204721711881576 0.41815783700527 no 1394 0.418894778020652 2007 5598863 SGTC_1960 st011366 51.8 µM 0.204182345337282 0.418364883327204 no 1395 0.419105503559719 1985 3972846 SGTC_1432 4049-0298 68.4 µM 0.204016336571735 0.418428613570969 no 1396 0.419170366328379 2073 741646 SGTC_2516 gossypol 71.55 µM 0.203836042288436 0.418497830405784 no 1397 0.419240813207857 2027 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3222 9128301 49.47 µM 0.203685894341852 0.41855547567711 no 1398 0.419299482902505 1934 4911358 SGTC_2556 citropten 84.59 µM 0.203508712987746 0.418623501948889 no 1399 0.419368718098226 1871 2775 A potential DNA crosslinker. SGTC_877 0771-0151 33.1 µM 0.201601959204686 0.419355726671657 no 1400 0.420113956727253 1964 6166523 SGTC_3354 9151612 71.43 µM 0.201501207132318 0.419394424912568 no 1401 0.42015334281756 2041 27261949 SGTC_2732 terfenadine 20 µM 0.201118662505839 0.419541365008321 no 1402 0.420302894783846 2032 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2192 5915882 198.485 µM 0.200964498388694 0.419600584514764 no 1403 0.420363166945802 1983 2876149 SGTC_2381 9035592 200 µM 0.200814437537365 0.419658229570757 no 1404 0.420421836684201 1885 4749657 SGTC_1647 st011722 22.4 µM 0.200691570455486 0.419705429572604 no 1405 0.420469875709989 2015 2854783 SGTC_225 nsc-122657 1.016 µM 0.199206454002235 0.420276035632358 no 1406 0.421050625518942 2019 275685 SGTC_2782 7736369 71.43 µM 0.198915105717128 0.420387996116138 no 1407 0.421164576489597 1930 2950836 YOL077C BRX1 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.198736116321731 0.420456782071423 no 1408 0.421234585378212 2065 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1702 st027038 51 µM 0.197869177343994 0.420789982661421 no 1409 0.421573710136393 1982 5521182 SGTC_44 0929-0055 61.211 µM 0.197735914996641 0.420841205944598 no 1410 0.421625844185252 1933 1379590 SGTC_686 1319-0111 510 µM 0.197233587431144 0.421034302285449 no 1411 0.421822373925755 2045 4562600 SGTC_138 0850-0259 40.9225 µM 0.196524142240485 0.421307047662446 no 1412 0.422099969155865 2059 6813004 SGTC_2384 9036245 200 µM 0.194398344266731 0.422124533830371 no 1413 0.422931993137778 2034 6462766 SGTC_3316 9136639 10.545 µM 0.193158636328367 0.422601424841942 no 1414 0.423417366032585 2016 4903665 SGTC_93 0109-0045 59.227 µM 0.193150119053378 0.422604701661649 no 1415 0.423420701135749 2081 88733 SGTC_1097 itavastatin 7.23 µM 0.193054866499226 0.422641348189361 no 1416 0.423457999482736 1967 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1929 genistein trimethyl ether 50.5 µM 0.192486876099477 0.422859885099972 no 1417 0.423680423526319 2115 136420 SGTC_41 0478-0632 82.643 µM 0.192260259198104 0.422947083621412 no 1418 0.423769173098035 2123 3750424 SGTC_2886 9058944 51.95 µM 0.191906871887252 0.423083068879837 no 1419 0.423907577253399 2015 4949929 SGTC_2070 5230947 200 µM 0.191784884836583 0.42313001225417 no 1420 0.423955355667168 2076 2835538 SGTC_1992 st073643 23.3 µM 0.191408321448975 0.423274929238566 no 1421 0.424102850512045 1942 3161292 SGTC_1881 5652484 16 µM 0.190719904336799 0.423539887105775 no 1422 0.424372521761382 2081 2255129 SGTC_2406 ethylparaben 405.7 µM 0.190265628361117 0.423714747713951 no 1423 0.424550493114678 1695 8434 A possible steroid mimic. SGTC_3156 9099931 49.47 µM 0.186209655596062 0.425276640915707 no 1424 0.426140176157521 1958 18111053 SGTC_1232 0279-0259 161 µM 0.185238907988152 0.425650635966843 no 1425 0.426520826485318 1918 1560000 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.184689306200447 0.425862407966776 no 1426 0.426736367149324 2041 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1567 st069303 68.4 µM 0.184115684434889 0.426083458126476 no 1427 0.426961351207582 1961 5581319 SGTC_2767 sibutramine 71.45 µM 0.181999733362593 0.426899058701126 no 1428 0.427791467576168 2089 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1053 3366-3204 134 µM 0.181603600832209 0.427051784186192 no 1429 0.427946911393864 1920 3632071 YPR165W RHO1 SGTC_3261 9137475 49.47 µM 0.181514472719393 0.42708614827019 no 1430 0.427981887125148 2102 17027690 SGTC_3355 9151058 44.0485 µM 0.180001448795083 0.427669591426093 no 1431 0.428575715401491 2103 17015728 SGTC_3062 9077494 49.47 µM 0.179813901613944 0.427741923284686 no 1432 0.428649334797671 2043 16459633 SGTC_914 3820-6779 408 µM 0.179259215544067 0.427955864853765 no 1433 0.428867084681082 2008 2893481 SGTC_2303 7774051 200 µM 0.179074772765789 0.428027008846943 no 1434 0.428939495109654 2066 2953184 SGTC_2884 9058502 51.95 µM 0.178994302349196 0.428058048945437 no 1435 0.428971087756692 1990 6471554 SGTC_3318 9139014 38.6185 µM 0.178396367137437 0.428288706243728 no 1436 0.42920585107432 1961 16643984 SGTC_143 4032-1194 15.74 µM 0.175821105598885 0.429282408749998 no 1437 0.430217244029484 1932 1806963 SGTC_544 k015-0020 52.4 µM 0.17419688241694 0.429909370077016 no 1438 0.430855367776154 1977 3008304 SGTC_1790 st045711 43.5 µM 0.173952385507371 0.4300037629145 no 1439 0.430951441239722 2108 585119 SGTC_3162 9099653 49.47 µM 0.173680281041646 0.430108818895418 no 1440 0.431058367716213 2097 25237511 SGTC_1969 st069479 40.1 µM 0.173155260217856 0.430311536557349 no 1441 0.431264694763949 2098 3895485 SGTC_2730 imipramine 71.33 µM 0.173020760426524 0.430363471708989 no 1442 0.431317554630469 2110 3696 A tricyclic antidepressant. SGTC_3117 9124945 49.47 µM 0.172509367238053 0.430560949792042 no 1443 0.431518548883542 1901 17592065 SGTC_1866 st057638 64 µM 0.172225245008473 0.430670673100694 no 1444 0.431630225880711 1988 688802 SGTC_1466 k213-0079 57.5 µM 0.171844786721799 0.430817608182949 no 1445 0.431779777256002 1997 3657981 SGTC_1125 tnp00248 1.32998 µM 0.171360219894712 0.431004764420363 no 1446 0.431970265998735 2115 24207736 SGTC_3280 9140961 49.47 µM 0.170837666532946 0.431206609716455 no 1447 0.432175705406549 1949 4901226 SGTC_2911 7942208 15.64 µM 0.17008027323986 0.431499197888482 no 1448 0.43247350357609 1961 1243384 SGTC_234 nsc-17383 10.7 µM 0.169720923370972 0.43163803128947 no 1449 0.432614809163808 2084 408974 SGTC_3317 9138495 8.753 µM 0.168329646805926 0.432175624977778 no 1450 0.433161975919912 2135 17020139 SGTC_2505 galangin 7.89 µM 0.167105824358676 0.432648617736468 no 1451 0.433643391640042 1923 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2200 6600604 21.907 µM 0.1636947051141 0.433967481969763 no 1452 0.43498574301433 2077 2904777 SGTC_2714 st079313 56.9 µM 0.163346156711981 0.434102285268318 no 1453 0.435122947046487 2013 2939799 SGTC_675 1309-0189 238 µM 0.162901400241455 0.434274308772509 no 1454 0.435298034161536 1991 4246530 SGTC_2213 7173844 200 µM 0.162767163664745 0.434326231422377 no 1455 0.435350881518742 2062 892728 SGTC_3024 9090631 49.47 µM 0.162591547739873 0.43439416129673 no 1456 0.435420021180655 2155 25236383 SGTC_450 aminopyrene 156 nM 0.16255360950744 0.434408836412664 no 1457 0.435434957651352 2089 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_175 3793-3120 23.7 µM 0.161694721719221 0.434741092111999 no 1458 0.435773130650746 2000 5322297 SGTC_1954 st077032 68.9 µM 0.161177978009109 0.434941013605976 no 1459 0.43597661266825 1898 698907 SGTC_721 1187-1332 279 µM 0.160464341722264 0.435217137643689 no 1460 0.436257654395473 2050 25730 SGTC_2819 7996655 46.38 µM 0.159592802974144 0.435554401000857 no 1461 0.436600924354224 2096 6456960 SGTC_2276 7947513 42.08 µM 0.159292183890094 0.435670743836437 no 1462 0.436719339243742 1858 2105100 SGTC_3282 9108498 15.4605 µM 0.156452798684881 0.436769889878384 no 1463 0.437838061094766 2004 16459645 SGTC_2558 carylophyllene oxide 100 µM 0.156209801915535 0.436863978445543 no 1464 0.437933825386231 2154 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1019 4262-0212 3.4 µM 0.155962553506066 0.436959716917374 no 1465 0.438031268967267 2149 4677213 SGTC_2794 7785382 27.27 µM 0.155174049966898 0.437265062521664 no 1466 0.438342052796653 2174 2205081 SGTC_1272 0839-0021 27 µM 0.153559519684396 0.437890400885688 no 1467 0.438978528442878 2061 5027250 SGTC_2000 st075254 36.4 µM 0.152194858032339 0.438419081416574 no 1468 0.43951662470849 2061 17234175 SGTC_2390 9097792 176.6 µM 0.151550237822639 0.438668850575433 no 1469 0.439770842192184 1966 4497149 SGTC_1733 st037357 54.9 µM 0.150691160094482 0.439001752931162 no 1470 0.440109673412629 1987 1272339 YGL099W LSG1 SGTC_1519 esterone 74 µM 0.150609794792178 0.439033285148647 no 1471 0.440141767204246 1913 698 A steroid. SGTC_2424 5537928 59.2 µM 0.150397498430246 0.439115560062525 no 1472 0.440225507393721 2010 5382802 SGTC_1130 3454-2858 15.9 µM 0.149758552896713 0.439363197633049 no 1473 0.44047755524537 1949 715628 YIL048W NEO1 SGTC_2610 ononetin 44.17 µM 0.146111297056123 0.440777224359252 no 1474 0.441916764183297 2022 259632 SGTC_2601 securinine 100 µM 0.145641055962975 0.440959590338421 no 1475 0.44210237777627 2025 442872 A GABA receptor antagonist. SGTC_3086 9117350 49.47 µM 0.144707378302258 0.441321720481602 no 1476 0.442470956719121 2155 2679265 SGTC_655 k060-0012 42 µM 0.142357299556391 0.442233423227885 no 1477 0.44339889441337 2040 5994525 SGTC_3210 9128157 49.47 µM 0.142193713749898 0.442296897073367 no 1478 0.44346349851935 1890 17590849 SGTC_1958 st076513 41.9 µM 0.141945086196635 0.442393371279824 no 1479 0.443561690604588 2058 732122 YGL099W LSG1 SGTC_298 1391-0729 10 µM 0.141194863194191 0.442684498753987 no 1480 0.443858002000296 2050 3237558 SGTC_2597 laccaic acid a 100 µM 0.140083610847233 0.44311578215142 no 1481 0.444296964776699 2058 5491415 A textile dye. SGTC_205 1486-1330 71.903 µM 0.138868570153742 0.443587423524115 no 1482 0.444777003831311 2075 4118834 SGTC_819 1013-0258 27.7 µM 0.138864128527403 0.443589147773672 no 1483 0.444778758780909 2060 5753198 SGTC_2903 5923464 63.88 µM 0.138791741016756 0.443617248922255 no 1484 0.444807360266164 2176 2876576 SGTC_1555 citronellol 128 µM 0.137763930557763 0.444016279969752 no 1485 0.445213495866287 2177 8842 A terpine precursor. SGTC_409 arachidonic acid 100 µM 0.137504272274014 0.444117097161533 no 1486 0.445316108018096 2114 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1024 4507-0395 26 µM 0.133924395284386 0.445507417266713 no 1487 0.446731179704861 2049 4201836 SGTC_1952 st077036 64.1 µM 0.132821349218009 0.445935944187973 no 1488 0.447167334859137 2192 2937007 SGTC_72 0744-0168 198.391 µM 0.13157814327944 0.44641899808242 no 1489 0.447658987166104 2053 677577 SGTC_146 3448-8650 53.125 µM 0.129197459494969 0.447344246044209 no 1490 0.448600703196393 2062 2891488 YIL048W NEO1 SGTC_191 3914-0123 66.505 µM 0.12634655858134 0.448452619679855 no 1491 0.449728801553058 2060 3144412 SGTC_1936 st074407 74.3 µM 0.126275941048654 0.448480079517515 no 1492 0.449756750028512 2062 809813 SGTC_1995 st072814 61.1 µM 0.125525062157212 0.448772076248513 no 1493 0.450053942610012 2022 5769371 SGTC_1846 st056244 14.8 µM 0.125052695484018 0.44895578125218 no 1494 0.450240916380088 2107 5393182 SGTC_734 2023-0417 80 µM 0.121821162787253 0.450212826779856 no 1495 0.451520326649036 2145 3935732 SGTC_1558 st069300 45.6 µM 0.121539114718284 0.450322565562913 no 1496 0.451632017628857 2193 24208000 SGTC_2529 gangaleoidin 93.61 µM 0.121234697706308 0.450441011878104 no 1497 0.451752571001797 2116 4565183 SGTC_1330 1469-0054 61.8 µM 0.1208529073351 0.450589569810012 no 1498 0.451903771589589 2202 7102664 SGTC_1042 0350-0096 82 µM 0.118517701888523 0.451498368322826 no 1499 0.452828734933648 1999 3122515 SGTC_729 4092-0585 94.1 µM 0.116121536767426 0.452431154953619 no 1500 0.453778110202456 2088 2169061 SGTC_2457 5731572 11.68 µM 0.115747780224859 0.452576675871958 no 1501 0.453926218784656 2216 2865357 SGTC_1842 st055362 61.2 µM 0.113878935041327 0.453304399957572 no 1502 0.4546668821615 2096 676032 SGTC_3097 9117246 49.47 µM 0.113018996085925 0.453639311077227 no 1503 0.45500774750327 2218 16423892 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.109233909726184 0.455113836494915 no 1504 0.45650848257499 2180 23847180 SGTC_667 1498-1044 59 µM 0.109081746651383 0.455173126501021 no 1505 0.456568826275313 2134 6739982 SGTC_418 lividomycin a 100 µM 0.10700928875574 0.455980754010373 no 1506 0.457390805354848 2237 72394 An antibiotic. SGTC_2049 5262831 67.185 µM 0.106165823198414 0.456309501013482 no 1507 0.457725393397628 2133 763417 SGTC_1228 0124-0032 52.5 µM 0.105031326223373 0.456751726816373 no 1508 0.458175475727884 2169 X1228 SGTC_1683 st010134 710 nM 0.104893217318717 0.456805565199668 no 1509 0.458230270536976 2181 3818134 SGTC_1557 sumaresinolic acid 42.3 µM 0.10354901140908 0.45732961230653 no 1510 0.458763626520577 2171 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2751 anetholtrithion 17.25 µM 0.102682726664335 0.457667378226434 no 1511 0.459107391647535 2185 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_39 0986-0283 58.349 µM 0.101024102182791 0.458314163891695 no 1512 0.459765663638877 2214 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3249 9135183 49.47 µM 0.100939891909043 0.458347004903251 no 1513 0.459799087823032 2174 4902779 SGTC_2854 9024559 71.43 µM 0.100854631263525 0.458380255837061 no 1514 0.459832929203243 2139 3163529 SGTC_1520 flindersine 88 µM 0.100108325424868 0.458671321236294 no 1515 0.460129162902596 2222 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_764 1951-2361 146 µM 0.0999599167400203 0.458729204487212 no 1516 0.460188073907015 2048 5438930 SGTC_2237 6667747 47.222 µM 0.0994900732943817 0.458912461428122 no 1517 0.460374584579992 2071 729940 YDL015C TSC13 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0972448445048524 0.459788306550034 no 1518 0.461265978006363 2205 6728940 SGTC_2750 bromebric acid 70.15 µM 0.09701378488986 0.459878452137042 no 1519 0.46135772366454 2162 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0969544677937992 0.459901594438915 no 1520 0.461381276732082 2235 5355888 SGTC_2105 5350118 200 µM 0.0958271737955938 0.460341428925705 no 1521 0.461828917550912 2142 2133313 SGTC_2090 5301565 104.445 µM 0.0944453290207984 0.460880647230183 no 1522 0.462377704674648 2169 2056344 SGTC_1337 1486-1011 40.3 µM 0.0943998746553507 0.460898385490276 no 1523 0.462395757686244 2255 X1337 SGTC_2619 obliquin 87.91 µM 0.0938918363421461 0.461096649307913 no 1524 0.462597539422474 2198 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3325 9138760 55.175 µM 0.0934442608263685 0.461271325310793 no 1525 0.462775314631344 2124 43844959 SGTC_15 0266-0086 27.098 µM 0.093195585796013 0.461368379338489 no 1526 0.462874090576527 2239 1712902 YIL048W NEO1 SGTC_1475 4092-1048 11.7 µM 0.0926745834052523 0.461571725986557 no 1527 0.46308104479896 2140 2881759 SGTC_2355 9061122 103.12 µM 0.0922276468061644 0.461746172847108 no 1528 0.463258586337639 2225 5302957 SGTC_2444 5485484 36.41 µM 0.0918440918033214 0.461895886675733 no 1529 0.463410955944595 2202 6790631 SGTC_255 tunicamycin 200.472 nM 0.091799248464836 0.461913390823025 no 1530 0.463428770590201 2240 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2137 5261020 140 µM 0.0910190497380951 0.462217945346232 no 1531 0.46373872719107 2214 763655 SGTC_1987 st072290 61.9 µM 0.0898621598222064 0.462669583908371 no 1532 0.464198375768999 2129 54697379 SGTC_1274 0865-0114 173 µM 0.089253065674553 0.462907387712105 no 1533 0.464440396652543 2169 870624 SGTC_1835 st008666 49.2 µM 0.0891760331280222 0.462937463865182 no 1534 0.464471006135558 2112 690455 SGTC_2866 9034245 58.44 µM 0.0891302926792623 0.462955322608326 no 1535 0.464489181559035 2258 6462273 SGTC_2365 9042475 200 µM 0.0888551918632801 0.463062733596307 no 1536 0.464598497173486 2148 6464479 SGTC_2653 dihydrofissinolide 100 µM 0.0869110164576326 0.463821898179502 no 1537 0.465371121395248 2197 6857746 SGTC_1945 st075991 56.6 µM 0.0867665177303562 0.463878327557305 no 1538 0.465428551100349 2078 1084980 SGTC_1117 retinoic acid 1.10837 µM 0.0867429344729619 0.463887537316712 no 1539 0.465437924119916 2234 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1776 st049249 45.9 µM 0.0863475321462977 0.464041953143001 no 1540 0.465595077177052 2139 1822314 SGTC_2462 5162487 171.77 µM 0.0857823522940205 0.464262681308669 no 1541 0.465819717794524 2257 2259986 SGTC_925 2064-1272 59.6 µM 0.0857602381071368 0.464271318117845 no 1542 0.465828507686764 2065 6815817 SGTC_1072 oxiconazole 14.9 nM 0.0848440145014909 0.464629168699729 no 1543 0.466192700579199 2274 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_583 1488-1091 88.9 µM 0.0843301438977896 0.464829884316278 no 1544 0.46639697319606 2270 4303273 SGTC_666 0272-0154 136 µM 0.0835745989429687 0.465125013118248 no 1545 0.466697331685541 2186 6870312 SGTC_176 1486-1328 72.834 µM 0.0834009974674852 0.46519282754476 no 1546 0.466766347706181 2193 22310231 SGTC_974 1326-0144 138 µM 0.082713625940216 0.465461347300027 no 1547 0.46703962503373 2159 5411856 SGTC_1407 3909-7909 12.3 µM 0.081025954555973 0.466120697841774 no 1548 0.467710655806018 2224 4411780 SGTC_1816 st051957 91.6 µM 0.080430919012412 0.466353192505354 no 1549 0.46794726837009 2238 674121 SGTC_3194 9111903 49.47 µM 0.078335540910233 0.46717199788746 no 1550 0.468780573377786 2240 17087251 SGTC_2069 5228469 200 µM 0.0766859277902123 0.467816710780446 no 1551 0.469436699784675 2201 2835210 SGTC_206 4546-0025 72.014 µM 0.0761059934306803 0.468043384771383 no 1552 0.469667385952364 2169 6620745 YIL048W NEO1 SGTC_3234 9132280 49.47 µM 0.0751281753851604 0.468425599586732 no 1553 0.470056365225845 2181 17612295 SGTC_2989 9073649 71.4286 µM 0.0743713488988927 0.468721452024335 no 1554 0.470357452958962 2295 21367202 SGTC_1123 mangostin 811.285 nM 0.0742421367596261 0.468771964310814 no 1555 0.470408859029235 2138 5281650 An antioxidant. SGTC_2654 protoveratrine a 100 µM 0.0742282688802239 0.468777385644775 no 1556 0.470414376289266 2254 5702278 A heart drug and vasodilator. SGTC_2330 7979373 200 µM 0.0735046658062903 0.469060269917569 no 1557 0.470702265672171 2207 1863007 SGTC_2832 7992762 51.95 µM 0.0734650937472431 0.469075740609231 no 1558 0.470718010072109 2139 2985177 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0732789102018414 0.469148529669868 no 1559 0.470792086897113 2284 688801 SGTC_3137 9097352 49.47 µM 0.0725022622695073 0.469452173791288 no 1560 0.47110110258923 2225 44120435 SGTC_2401 5128683 200 µM 0.0713291725140601 0.469910847420787 no 1561 0.471567889023155 2227 708373 SGTC_478 N-arachidonylglycine 10 µM 0.0712488149856861 0.469942268376677 no 1562 0.471599865680824 2278 5283389 SGTC_1819 st053448 58.6 µM 0.0703526197718707 0.470292706306693 no 1563 0.471956500850123 2219 2857616 SGTC_361 000s-0510 1.45 µM 0.0700586517753159 0.470407661215824 no 1564 0.472073488450995 2214 660 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0692386795625032 0.470728320793774 no 1565 0.472399817564738 2255 107982 A Capsaicinoid. SGTC_640 3381-0960 37.1 µM 0.0692267860012865 0.470732972048023 no 1566 0.472404551051361 2262 1745025 SGTC_2091 4-phenylthiadiazole 200 µM 0.0689117180454451 0.470856188165513 no 1567 0.472529945521604 2245 270010 SGTC_1752 st044819 83.042 µM 0.0687656655100609 0.470913307032891 no 1568 0.472588074160787 2224 441209 YML126C ERG13 SGTC_1884 5633444 25 µM 0.067892070175556 0.471254968988522 no 1569 0.472935775636248 2234 5724239 SGTC_1944 st076371 56.9 µM 0.0666500511248464 0.471740757324968 no 1570 0.473430149631481 2186 24208455 SGTC_3005 9076496 71.4286 µM 0.0655048637658329 0.472188709356122 no 1571 0.473886016965094 2308 21368410 SGTC_1682 st012968 530 nM 0.0645469313949117 0.472563441683217 no 1572 0.474267369572731 2135 24207270 SGTC_2927 9011802 47.9 µM 0.0645419780515872 0.472565379438594 no 1573 0.474269341558897 2202 43912568 SGTC_947 3447-0010 211 µM 0.0642210158205147 0.472690941729402 no 1574 0.474397121864901 2292 748350 SGTC_1304 1165-0502 251 µM 0.0625223319361737 0.473355521632406 no 1575 0.475073439207125 2256 767425 SGTC_2191 5911152 200 µM 0.0613055775091827 0.473831600891556 no 1576 0.475557924474769 2296 2875902 SGTC_482 fipronil 114 µM 0.0612165324363557 0.473866443015196 no 1577 0.475593381722655 2302 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1781 st038725 66.3 µM 0.0604788716304249 0.474155087299759 no 1578 0.475887121519048 2225 4270275 YIL048W NEO1 SGTC_2096 5468907 200 µM 0.0603845869864573 0.47419198155672 no 1579 0.475924667029286 2280 759785 SGTC_1170 0310-0127 64.8 µM 0.0595311738807427 0.474525938252195 no 1580 0.476264518166681 2264 774975 SGTC_1505 k297-0037 20.6 µM 0.0595100325508859 0.474534211482756 no 1581 0.476272937410371 2239 4089396 SGTC_1792 st045773 43.6 µM 0.0591751281532932 0.47466527098734 no 1582 0.47640630988859 2257 2919270 SGTC_1081 sertraline 6 µM 0.0576237880359099 0.475272398786638 no 1583 0.477024150520317 2305 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_3202 9113761 49.47 µM 0.0567150384871582 0.475628071035488 no 1584 0.477386097158954 2277 4798415 SGTC_1515 3460-0031 42.1 µM 0.0555238265335231 0.476094324608682 no 1585 0.477860574198799 2276 2876596 SGTC_2753 fluvastatin 17.09 µM 0.0548567079991138 0.476355456543729 no 1586 0.478126310962432 2248 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1811 st050069 61.5 µM 0.0534254809381751 0.47691571957561 no 1587 0.478696451673863 2319 3877702 SGTC_1492 4158-0558 28.5 µM 0.0529515791076303 0.477101241603983 no 1588 0.47888524391162 2297 3967268 SGTC_2576 guaiol 23.12 µM 0.0498651021641394 0.478309648311694 no 1589 0.480114943564454 2314 227829 SGTC_632 0781-2353 4.65 µM 0.0498254172185974 0.478325186945796 no 1590 0.480130755911636 2265 6811515 YHR007C ERG11 SGTC_1068 loratadine 26.9 µM 0.0496616498398768 0.478389310385095 no 1591 0.480196008861551 2222 3957 A H1 histamine antagonist. SGTC_2298 7976326 193.81 µM 0.0492876358829267 0.478535758380742 no 1592 0.480345036339633 2282 2235818 SGTC_1644 st010134 20.9 µM 0.0491867198433052 0.478575273317154 no 1593 0.480385247243398 2318 3818134 SGTC_1022 4477-0945 21.3 µM 0.0480520682346099 0.47901957473815 no 1594 0.480837373025744 2310 4648966 SGTC_1201 1889-3372 45.9 µM 0.0479927855021441 0.479042789106944 no 1595 0.480860996159222 2229 5392199 SGTC_757 1066-0008 322 µM 0.0462982110887433 0.479706392785397 no 1596 0.481536282563257 2300 6842497 SGTC_3319 9138450 16.7555 µM 0.0462296254059823 0.479733252473061 no 1597 0.481563615025758 2201 2029690 SGTC_3028 9087778 49.47 µM 0.045913554496677 0.47985703409917 no 1598 0.481689575322477 2309 17217395 SGTC_1403 3909-7815 62.9 µM 0.0451163076602536 0.48016926539249 no 1599 0.482007301512326 2287 6615483 SGTC_1387 3342-1166 1.8 µM 0.0447118516140821 0.480327669975781 no 1600 0.482168493462379 2262 3418228 SGTC_2571 chrysanthemic acid 100 µM 0.0443945255199788 0.480451952424535 no 1601 0.482294962675305 2218 2743 An insecticide. SGTC_727 3032-0951 202 µM 0.0442950673282706 0.480490906144819 no 1602 0.482334601759571 2286 3652836 SGTC_123 0083-0120 66.675 µM 0.0441100596257742 0.480563366617219 no 1603 0.482408337084498 2301 16001701 SGTC_111 0083-0039 52.457 µM 0.0425634741281623 0.481169130161731 no 1604 0.483024756255683 2327 759313 SGTC_167 3672-0051 66.205 µM 0.0423820274979367 0.481240201695492 no 1605 0.48309707772699 2329 3237971 SGTC_2697 mebhydrolin 72.4 µM 0.0412435498883926 0.481686149919705 no 1606 0.483550867700195 2317 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_381 3461-2219 42.7 µM 0.0407107765707197 0.481894848196502 no 1607 0.483763235129071 2338 2883159 SGTC_740 k014-0057 261 µM 0.0404047013472787 0.482014746410396 no 1608 0.483885241089288 2319 4012779 SGTC_2567 aureobasidin a 60 nM 0.0376006941339635 0.483113228697021 no 1609 0.485003027237932 2257 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2552 juarezic acid 87.02 µM 0.0360772620676554 0.483710094256955 no 1610 0.485610376382063 2345 1549512 SGTC_3148 9097893 49.47 µM 0.0358803222032917 0.483787256033683 no 1611 0.485688893185119 2303 17174100 SGTC_630 4356-0227 183 µM 0.0354449860702174 0.483957824512104 no 1612 0.485862456767075 2344 779312 SGTC_2368 9071271 200 µM 0.035170826303071 0.48406524419887 no 1613 0.485971762535272 2304 27209959 SGTC_2521 angolensin 13.4 µM 0.0338850326593475 0.484569051695928 no 1614 0.486484414271197 2297 821428 A flavenoid. SGTC_3065 9113888 49.47 µM 0.0325285777891953 0.48510057279233 no 1615 0.487025263151852 2318 16648368 SGTC_3034 9090421 49.47 µM 0.0312295758429233 0.485609606031891 no 1616 0.487543226650447 2343 17173761 SGTC_2808 7946468 45.46 µM 0.0271420851718171 0.487211499183949 no 1617 0.489173204000112 2336 2970879 SGTC_389 tpck 16.7 µM 0.0267969030584588 0.487346786333654 no 1618 0.48931086166688 2332 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2006 4011487 200 µM 0.0260451204978192 0.487641437325062 no 1619 0.489610674845393 2351 45595294 SGTC_3175 9106517 49.47 µM 0.0255608490004839 0.487831244561289 no 1620 0.489803806915195 2336 41468073 SGTC_1942 st076330 65.2 µM 0.0255051178157776 0.487853088234184 no 1621 0.489826033194903 2326 24208414 SGTC_1323 1348-1351 11.2 µM 0.025400603627184 0.487894052359256 no 1622 0.489867714819747 2255 6989654 SGTC_1234 0326-0494 15.5 µM 0.025373590994178 0.487904639926978 no 1623 0.489878487828971 2338 1547813 SGTC_2745 rifampicin 24.3 µM 0.0248647005624697 0.488104100479891 no 1624 0.490081441696929 2355 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_3096 9117468 49.47 µM 0.0238955855465537 0.488483955103181 no 1625 0.490467947751226 2362 41316311 SGTC_2612 dictamnine 15.46 µM 0.0235129976698172 0.488633917261656 no 1626 0.490620535355285 2316 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1506 4226-2149 212 µM 0.0229339680910851 0.488860881306819 no 1627 0.490851472448552 2288 991114 SGTC_2922 7999257 32.47 µM 0.0224925878171111 0.489033892947855 no 1628 0.491027512285431 2369 2988377 SGTC_1725 st036284 20.55 µM 0.0215527927359618 0.489402279382451 no 1629 0.49140234535659 2359 707914 SGTC_2914 7968218 45.32 µM 0.0198513533685981 0.49006924243416 no 1630 0.492080975938018 2354 2977111 SGTC_2035 5154463 94.595 µM 0.0194669443463662 0.490219934416538 no 1631 0.492234303317001 2367 2769623 SGTC_1398 3558-0053 112 µM 0.0189793533397365 0.49041107672092 no 1632 0.492428788045925 2356 4532369 SGTC_517 1365-0151 113 µM 0.0187829086237288 0.490488086345445 no 1633 0.492507144180664 2315 768657 SGTC_480 am 92016 50 µM 0.0185432212913009 0.490582048281063 no 1634 0.492602748939921 2319 2129 K+ channel blocker. SGTC_1834 st055981 52.8 µM 0.01709358057163 0.491150345619659 no 1635 0.493180980063616 2378 471719 YDL150W RPC53 SGTC_2059 5238311 157 µM 0.0166394347702172 0.491328386483639 no 1636 0.493362132254873 2371 703021 SGTC_696 1560-0013 611 µM 0.0162943964979799 0.491463654578754 no 1637 0.493499763948019 2358 1650269 SGTC_5 0352-0601 109.883 µM 0.0157061153676379 0.491694285359366 no 1638 0.493734424120906 2321 762456 SGTC_1239 0337-0584 35.4 µM 0.0154936192392856 0.49177759340612 no 1639 0.493819187496309 2375 914301 YML130C ERO1 SGTC_1482 3346-2049 8.48 µM 0.0144715329451833 0.492178302184326 no 1640 0.494226895152317 2380 3826804 SGTC_496 calpeptin 138 µM 0.0124682652380527 0.492963705509455 no 1641 0.49502601070772 2318 73364 A calpain inhibitor. SGTC_2495 cafestol 54.53 µM 0.0117487317169684 0.493245813424759 no 1642 0.495313042002831 2353 16667697 An anti-infammatory. SGTC_3231 9132313 49.47 µM 0.0114616848378352 0.493358357007819 no 1643 0.495427549427743 2367 4905967 SGTC_1055 3448-0672 86 µM 0.0113634883918762 0.493396857390999 no 1644 0.495466721590692 2365 748378 SGTC_483 fpl-64176 144 µM 0.0110673715477477 0.493512957808688 no 1645 0.495584847689791 2381 3423 SGTC_2031 5180455 200 µM 0.010050387730592 0.493911697256857 no 1646 0.495990542899359 2389 29949 SGTC_1090 efavirenz 20.7 µM 0.00936807113422368 0.494179223672837 no 1647 0.496262735003031 2353 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2435 5706476 10.6 µM 0.00927300728332174 0.494216497036989 no 1648 0.496300658345196 2385 5725375 SGTC_114 0364-0001 490.298 µM 0.0085401742538871 0.494503833505197 no 1649 0.496593004822804 2364 4003655 SGTC_687 k029-0044 34.9 µM 0.00682883516366083 0.495174843215353 no 1650 0.497275710100971 2392 5829338 SGTC_1270 0831-1170 17.3 µM 0.00621379887053864 0.495416000098691 no 1651 0.497521068861099 2397 6764716 SGTC_2397 5161689 200 µM 0.0061181997128955 0.495453484860248 no 1652 0.497559206682041 2389 2259942 SGTC_1309 pyrazolanthrone 13.4 µM 0.00511492011663714 0.495846876630623 no 1653 0.497959451002214 2399 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1195 1502-0147 41.1 µM 0.004613851512444 0.496043350083454 no 1654 0.49815934608672 2394 817940 SGTC_928 2764-0428 58.7 µM 0.00447371916651864 0.496098297395464 no 1655 0.498215250227214 2353 662578 SGTC_3009 9080819 71.4286 µM 0.00336497452890025 0.496533049921628 no 1656 0.498657571921346 2394 17027216 SGTC_556 4058-0063 51.5 µM 0.00299943317159937 0.496676384150112 no 1657 0.498803401084831 2397 6615692 SGTC_492 tmb-8 126 µM 0.00289193090571613 0.496718537477445 no 1658 0.498846288097843 2397 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_794 k038-0031 316 µM 0.00189910660104473 0.497107841155343 no 1659 0.499242366537268 2402 6624242 SGTC_2056 5235370 200 µM 0.000873417789417284 0.497510034466204 no 1660 0.499651556759649 2404 5511916 SGTC_3297 9117502 71.43 µM 0 0.497852521243119 no 1661 0.5 2405 7453720 SGTC_1399 3562-5772 25 µM -4.61975496388265e-05 0.497870636388585 no 1662 0.499981569844205 2407 23847490 SGTC_1650 st011916 45.8 µM -0.000273929479992429 0.497959935496638 no 1663 0.499890717949949 2407 242528 SGTC_3341 9147222 25.867 µM -0.000659990963872104 0.498111319620734 no 1664 0.499736701718943 2409 1939759 SGTC_2296 7971656 126.45 µM -0.000718973374784565 0.498134448087159 no 1665 0.499713171147027 2409 666570 SGTC_2353 9059630 146.67 µM -0.000784749478379324 0.4981602405364 no 1666 0.499686930285685 2394 4779114 SGTC_1741 st038134 10.228 µM -0.00106560824211424 0.498270372341353 no 1667 0.499574883898331 2409 1272587 SGTC_3251 9135047 49.47 µM -0.00110384095227284 0.498285364361674 no 1668 0.499559631262729 2407 17682963 SGTC_3302 9125395 16.351 µM -0.00111843309581523 0.498291086313795 no 1669 0.499553809843302 2411 17599668 SGTC_219 mitoxanthrone 164.414 µM -0.00141627671139436 0.498407878476614 no 1670 0.499434987527964 2395 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_333 3486-0131 40.1 µM -0.00314635826856966 0.499086290453701 no 1671 0.498744786728389 2410 6744690 SGTC_2985 9022375 71.43 µM -0.00341569138748588 0.499191903573552 no 1672 0.498637338938412 2439 4939335 SGTC_2321 7390090 138.78 µM -0.00370532482861431 0.49930547708586 no 1673 0.498521792645737 2418 649046 SGTC_1167 k781-0610 148 µM -0.00392652760397972 0.499392217025676 no 1674 0.498433546148775 2414 4525169 SGTC_1054 3429-0080 167 µM -0.00488813793106728 0.49976929224034 no 1675 0.498049922872689 2417 1162877 SGTC_1797 st048695 56.8 µM -0.00533276073398301 0.499943641787931 no 1676 0.497872546355495 2414 592262 YIL048W NEO1 SGTC_959 1222-0044 107 µM -0.00547648433307288 0.5 no 1677 0.497815209772581 2417 6083612 SGTC_996 3970-0799 1.8 µM -0.00668820257676294 0.499524850071527 no 1678 0.497331813104501 2383 6615648 YGL040C HEM2 SGTC_1843 st055809 45.5 µM -0.0076392162163723 0.499151930431032 no 1679 0.496952423303746 2452 16413835 SGTC_1203 3992-3522 103 µM -0.00817951496294892 0.498940064152898 no 1680 0.496736882034338 2419 5322312 SGTC_821 1114-0266 29.2 µM -0.0090616752084084 0.498594145071407 no 1681 0.496384964102319 2436 3123235 SGTC_3145 9085516 49.47 µM -0.0100195882937238 0.498218522441722 no 1682 0.496002829478287 2446 25236195 SGTC_883 0850-0245 24.6 µM -0.0104288155369072 0.498058054260478 no 1683 0.495839579962638 2494 6823229 YPR165W RHO1 SGTC_207 4185-0010 4.486 µM -0.0111521190157705 0.497774429759525 no 1684 0.495551040428069 2418 3761753 SGTC_2902 5787006 60.46 µM -0.0111851310834398 0.497761484968212 no 1685 0.495537871339883 2423 591003 SGTC_3272 9137413 49.47 µM -0.0121190905843077 0.49739525898624 no 1686 0.495165300713474 2428 17614870 SGTC_1423 4048-0112 5.59 µM -0.0122431791726645 0.49734660129063 no 1687 0.495115800201675 2427 X1423 SGTC_783 0848-0141 92.7 µM -0.0123476438654711 0.497305638559907 no 1688 0.495074127968988 2425 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3275 9138069 49.47 µM -0.0127714497825723 0.497139455936066 no 1689 0.494905067205773 2476 17617007 SGTC_1159 4092-0538 61.2 µM -0.0136034018455864 0.496813232662777 no 1690 0.494573195221024 2428 717301 SGTC_1162 k048-0130 20.1 µM -0.0151290408077211 0.49621500805262 no 1691 0.493964616198456 2434 6797406 SGTC_2920 7982904 15.77 µM -0.0152804803245209 0.496155626918994 no 1692 0.493904207555521 2438 6456808 SGTC_625 k213-0058 121 µM -0.0159897641216838 0.495877509939474 no 1693 0.49362127885003 2453 3655420 SGTC_2810 7959871 45.46 µM -0.0160309651751002 0.495861354671546 no 1694 0.493604844114334 2449 2974535 SGTC_485 niflumic acid 177 µM -0.016116594450139 0.495827778758548 no 1695 0.493570687388851 2439 4488 A COX2 inhibitor. SGTC_2674 ligustilide 100 µM -0.0164222726503918 0.495707920172012 no 1696 0.493448755569455 2450 5319022 A signalling regulator. SGTC_890 0929-0006 47.2 µM -0.0170700660820583 0.495453917074956 no 1697 0.493190359619184 2438 1378169 SGTC_103 0844-0104 51.839 µM -0.01722880942941 0.495391673278828 no 1698 0.49312703949827 2457 5375804 SGTC_3181 9108277 49.47 µM -0.017495543613982 0.495287086168528 no 1699 0.493020643992145 2430 17097298 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0177734624961457 0.49517811385632 no 1700 0.492909787638041 2448 689007 SGTC_2893 9048488 25.97 µM -0.0177977945034314 0.495168573265389 no 1701 0.492900082106758 2440 6467338 SGTC_1180 1193-0155 285 µM -0.0181368758747876 0.495035619598178 no 1702 0.49276483004502 2463 2921347 SGTC_2694 st077685 81.9 µM -0.0182369528713256 0.49499637955344 no 1703 0.49272491170214 2440 2838096 SGTC_1636 st007707 68.9 µM -0.0191163925149335 0.494651554673117 no 1704 0.492374127241867 2451 403051 SGTC_2708 st078559 56 µM -0.0197905092962524 0.494387238784458 no 1705 0.492105244443341 2441 17250902 SGTC_164 4100-3994 89.624 µM -0.0201755876519437 0.494236253687841 no 1706 0.491951651076621 2433 4615967 SGTC_1146 3579-1023 7 µM -0.0214242247506306 0.493746682252829 no 1707 0.491453624721166 2492 X1146 SGTC_3026 9090633 49.47 µM -0.022187362559029 0.493447472225511 no 1708 0.491149249163778 2443 25236842 SGTC_1301 naphtanilide LB 4.81 µM -0.0222144530335294 0.493436850696112 no 1709 0.491138444291186 2441 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0223331394669355 0.493390316629202 no 1710 0.491091106998811 2444 16623 A steroid. SGTC_1801 st050089 28.441 µM -0.0227015166003608 0.493245885481004 no 1711 0.490944183038139 2438 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2180 6301957 200 µM -0.0238314406558968 0.492802877081873 no 1712 0.490493530574849 2448 845462 SGTC_2260 7964312 200 µM -0.0256603493628405 0.492085837393472 no 1713 0.489764125029616 2479 231951 SGTC_132 0417-1715 25.805 µM -0.0258568194764068 0.492008811043556 no 1714 0.489685770793119 2454 6769098 SGTC_2906 7926292 26.41 µM -0.0276876032529066 0.491291064718093 no 1715 0.488955655542748 2482 2966319 SGTC_1521 st012942 49.4 µM -0.028808147183746 0.490851776855172 no 1716 0.48850880153252 2537 24207259 SGTC_1486 3970-0793 4.53 µM -0.0291148130249869 0.490731556276088 no 1717 0.48838651086044 2473 2844330 SGTC_2603 homopterocarpin 100 µM -0.0291719365467783 0.490709162538286 no 1718 0.488363731548097 2481 101795 A weak amylase inhibitor. SGTC_1899 st063254 59.6 µM -0.0299818295815754 0.490391668976915 no 1719 0.488040772274731 2457 3093813 SGTC_2235 salicylic acid 500 µM -0.0304362017635994 0.490213549043157 no 1720 0.487859586694294 2446 338 A COX inhibitor and kinase inhibitor. SGTC_1668 st014914 51.6 µM -0.0307951167080744 0.490072850993036 no 1721 0.487716467438532 2468 2839556 SGTC_2259 7964009 200 µM -0.030997255707977 0.489993611137408 no 1722 0.487635864125199 2579 313134 SGTC_2420 aureobasidin a 50 nM -0.0312420363773459 0.489897655987821 no 1723 0.487538258040896 2504 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_644 1498-1197 63.3 µM -0.031278753548844 0.489883262737807 no 1724 0.48752361716414 2488 6741615 SGTC_657 3534-0529 86.7 µM -0.0315605541578634 0.489772796427351 no 1725 0.487411250464524 2463 1049549 SGTC_136 0097-0015 404.482 µM -0.032727966315992 0.489315177358216 no 1726 0.48694576096886 2451 4861337 SGTC_3116 9124943 49.47 µM -0.0332328488334026 0.489117270542737 no 1727 0.48674445150083 2475 41905195 YPL160W CDC60 SGTC_201 4262-0159 12.803 µM -0.0339684702998755 0.488828922127768 no 1728 0.486451146620073 2464 1341029 SGTC_2837 9008476 45.46 µM -0.0344454394235025 0.4886419631976 no 1729 0.486260974766109 2525 2992805 SGTC_2345 9052315 157.45 µM -0.034718731174662 0.488534841382574 no 1730 0.486152012306736 2501 6469265 SGTC_2393 9031399 185.94 µM -0.0347369692674669 0.488527692650227 no 1731 0.486144740746561 2477 1526623 YDL150W RPC53 SGTC_1618 st003135 44.5 µM -0.0350525087869308 0.488404012125323 no 1732 0.486018935307996 2459 1270615 SGTC_2540 epiandrosterone 100 µM -0.0353571221009384 0.488284615350974 no 1733 0.485897487461615 2476 441302 A steroid. SGTC_3139 9095020 49.47 µM -0.0357158263936138 0.48814401832775 no 1734 0.485754475483081 2460 25236292 SGTC_3268 9137683 49.47 µM -0.036868304592312 0.487692305317252 no 1735 0.485295005914353 2463 1953228 SGTC_3004 9076122 71.4286 µM -0.0368929826637977 0.487682632935275 no 1736 0.485285167481544 2478 44782551 SGTC_3011 9081274 71.4286 µM -0.0370717438457558 0.487612569069529 no 1737 0.48521390084025 2494 6625322 SGTC_1632 st005650 90 µM -0.0376340191495225 0.48739219273504 no 1738 0.484989741883381 2521 2759605 SGTC_3 0833-0587 95.581 µM -0.0380085065285635 0.487245419514244 no 1739 0.48484044985071 2397 5382644 SGTC_2109 5483026 200 µM -0.038210568716093 0.48716622579107 no 1740 0.484759897216994 2497 759335 SGTC_147 4466-0538 29.23 µM -0.0387910366553561 0.486938727282599 no 1741 0.484528495585108 2585 6742687 YHR072W ERG7 SGTC_254 nsc-64875 3.808 µM -0.0401016825074046 0.486425071289479 no 1742 0.484006030217672 2500 56993 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0406276943643134 0.486218927955806 no 1743 0.483796352734578 2530 521171 SGTC_3166 9102297 49.47 µM -0.0419273742667034 0.485709601069576 no 1744 0.483278297035678 2505 25237072 SGTC_1138 3761-0006 1.03 µM -0.0423095479455669 0.485559836798059 no 1745 0.483125966971671 2468 12061087 SGTC_2878 9043973 25.97 µM -0.0433997015546881 0.485132644226369 no 1746 0.482691457801745 2606 6465167 SGTC_1983 st071813 46.9 µM -0.04359234478039 0.485057155932218 no 1747 0.482614676939474 2531 11838595 SGTC_1986 st071812 45 µM -0.0452224965513297 0.484418393816249 no 1748 0.481964981468277 2494 11838594 SGTC_2481 5478948 45.16 µM -0.0455267604843309 0.484299174772301 no 1749 0.481843722613057 2548 77792 SGTC_2812 7970281 58.44 µM -0.0460954628194058 0.484076345203233 no 1750 0.481617081155952 2532 2233435 SGTC_447 ml7 120 µM -0.0470181764801348 0.483714817141207 no 1751 0.481249370406451 2489 4216 Selective myosin light chain kinase inhibitor. SGTC_878 0828-0289 13.7 µM -0.0477730325870821 0.483419067221727 no 1752 0.480948564443445 2501 745350 YLR208W SEC13 SGTC_3230 9131665 49.47 µM -0.0479958327927312 0.483331776635414 no 1753 0.480859781865507 2492 15943720 SGTC_306 1672-3436 11.6 µM -0.0485771434530539 0.483104029502989 no 1754 0.480628142669012 2545 6797378 SGTC_2476 5806916 10.51 µM -0.0490534022148959 0.482917443932953 no 1755 0.480438369157626 2522 2870194 SGTC_2873 9040596 71.43 µM -0.0493745574068539 0.48279162594346 no 1756 0.480310401836842 2594 6463863 SGTC_3172 9105863 49.47 µM -0.0498650869321739 0.482599456000243 no 1757 0.480114949633579 2482 2348785 SGTC_2318 6029776 164 µM -0.0502955795979581 0.482430809438081 no 1758 0.479943423141675 2528 818325 SGTC_414 piperonyl butoxide 100 µM -0.0504305880716301 0.482377920182113 no 1759 0.479889630817141 2491 5794 A potent inhibitor of cytochrome P450. SGTC_91 0417-1751 58.384 µM -0.0504871184028011 0.482355774648242 no 1760 0.479867107169857 2486 6795624 SGTC_2954 9074818 52.69 µM -0.0513174212361057 0.482030513101901 no 1761 0.479536293127725 2546 16648742 SGTC_411 enrofloxacin 100 µM -0.051846368539112 0.481823310327561 no 1762 0.479325554229111 2506 71188 A bacterial gyrase inhibitor. SGTC_2588 indole-3-carbinol 100 µM -0.0527134759196773 0.481483651874082 no 1763 0.478980100861782 2547 3712 Induces cell cycle arrest. SGTC_155 k072-0202 43.6 µM -0.0532412644644361 0.481276916061881 no 1764 0.478769838966431 2482 5857737 SGTC_1900 st060200 72.8 µM -0.053759479703256 0.481073935031167 no 1765 0.478563396659996 2491 688945 SGTC_2846 9008642 19.48 µM -0.0539423066937881 0.481002324235469 no 1766 0.47849056492323 2593 2992898 SGTC_290 2043-6722 48.1 µM -0.0553652063078997 0.480445015327862 no 1767 0.477923757323143 2541 773758 YLR208W SEC13 SGTC_1363 1636-0063 10.4 µM -0.055592129676526 0.480356139468062 no 1768 0.477833367209352 2516 6072185 SGTC_2595 hexamethylquercetagetin 100 µM -0.056216997975275 0.480111411217213 no 1769 0.477584470075019 2559 386331 SGTC_380 3970-0968 6 µM -0.0562251741678126 0.48010820907945 no 1770 0.477581213397063 2523 2891601 SGTC_2875 9039966 71.43 µM -0.0563200989798193 0.480071032660833 no 1771 0.477543403787662 2602 6463691 SGTC_1665 st014639 11.4 µM -0.0570550496896989 0.479783201951052 no 1772 0.477250671604787 2517 981133 YIL048W NEO1 SGTC_2154 5570129 200 µM -0.0581948507606295 0.479336839518033 no 1773 0.476796711135417 2500 673366 SGTC_3054 9094397 49.47 µM -0.0586678678154781 0.479151606837044 no 1774 0.476608326502938 2529 2598354 SGTC_2859 9028643 45.46 µM -0.0600314563028946 0.478617653224199 no 1775 0.476065290676838 2584 17151580 SGTC_880 0833-0487 87.2 µM -0.0602944393513857 0.478514678777422 no 1776 0.47596056532259 2504 76075 SGTC_3184 9108758 49.47 µM -0.0617279118758121 0.477953409285694 no 1777 0.475389755942853 2485 902885 SGTC_3165 9101544 49.47 µM -0.0635624487919366 0.477235168834837 no 1778 0.474659316386692 2563 5002184 SGTC_394 menadione 8.33 µM -0.0641452024334349 0.47700703003348 no 1779 0.474427304797486 2501 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1197 1601-0112 267 µM -0.0646198256518079 0.47682122814117 no 1780 0.474238349556245 2511 7350313 SGTC_3211 9128781 49.47 µM -0.0650982118269127 0.47663395825425 no 1781 0.474047902084977 2640 17194361 SGTC_3311 9131146 2.8755 µM -0.0655114729562044 0.476472186484355 no 1782 0.473883385930982 2574 4900406 YPR165W RHO1 SGTC_3260 9137109 49.47 µM -0.0665543785309088 0.476063956628744 no 1783 0.473468232914563 2488 17478346 SGTC_1839 st053978 48 µM -0.066963194370152 0.475903938587269 no 1784 0.473305502021133 2518 3788398 SGTC_722 3534-0461 190 µM -0.0669949304798268 0.475891516652229 no 1785 0.473292869512919 2568 658262 SGTC_957 1187-1561 14.1 µM -0.067052134050223 0.475869126473836 no 1786 0.473270099790128 2506 1538454 SGTC_382 3229-0966 23.2 µM -0.0673071643058396 0.475769305434873 no 1787 0.473168586766784 2582 5722370 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0699881712256913 0.474720029453796 no 1788 0.472101537272231 2582 165506 SGTC_2273 7815444 169.05 µM -0.0704147857095373 0.47455307968458 no 1789 0.471931761582647 2521 2824616 SGTC_452 diindolylmethane 8 µM -0.07073173990719 0.474429046866695 no 1790 0.471805629649645 2591 3071 Inhibits expression of several cancer promoting factors. SGTC_1311 1190-0148 100 µM -0.0708892728521284 0.474367400852211 no 1791 0.471742940460398 2599 1961333 SGTC_2809 7964133 12.99 µM -0.0720004727809445 0.473932582043872 no 1792 0.471300765802314 2567 1253665 SGTC_2511 berberine 10.47 µM -0.0724269649891936 0.473765701452191 no 1793 0.471131063091482 2559 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1241 0364-0022 50.8 µM -0.0742768700989003 0.47304191244728 no 1794 0.470395040584959 2615 4563895 SGTC_1698 5-fluorocytosine 1.055 µM -0.0744300470422953 0.472981984796447 no 1795 0.470334100510624 2542 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_227 fluconazole 33.516 µM -0.0746929055255621 0.47287914769417 no 1796 0.470229526238395 2550 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2464 5717415 7.67 µM -0.0754889205616089 0.472567736880832 no 1797 0.469912856247605 2547 5285744 SGTC_2310 7668677 200 µM -0.0757990213097703 0.472446426204978 no 1798 0.469789497384168 2612 2197143 SGTC_1509 1326-1131 80 µM -0.0758241572915052 0.472436593180478 no 1799 0.46977949835382 2532 768313 SGTC_2149 5554786 194.827 µM -0.0761194870425579 0.472321063457284 no 1800 0.46966201835027 2559 745063 YPR165W RHO1 SGTC_1600 coumarin 106 71.1 µM -0.0762980173086909 0.472251225525912 no 1801 0.469591001603194 2690 100336 A hepatotoxic, DNA x-linker. SGTC_1935 st074532 41.6 µM -0.0774702157521842 0.471792703194317 no 1802 0.469124742216822 2678 2829742 SGTC_531 3788-1495 174 µM -0.07754347695102 0.471764047254442 no 1803 0.469095602883202 2528 2896655 SGTC_2245 6637752 200 µM -0.0781735048535706 0.471517619420622 no 1804 0.468845018784831 2626 681890 SGTC_1102 cgs 12066b 26.1 µM -0.0785739012651107 0.47136101484271 no 1805 0.468685773557123 2631 6438352 A 5-HT1B full agonist. SGTC_1481 3346-2004 36 µM -0.0798891347112341 0.470846626992922 no 1806 0.468162715726438 2547 2770522 SGTC_2933 9026794 32.47 µM -0.0802403308212565 0.470709282373196 no 1807 0.468023057099428 2596 17586027 SGTC_2655 perillic acid 100 µM -0.080980958901901 0.470419651419979 no 1808 0.467728547679165 2548 5702197 An apoptosis inducer. SGTC_355 1311-2252 105 µM -0.081407160663222 0.470252987503884 no 1809 0.467559077314148 2581 5338538 SGTC_356 1634-0012 32.5 µM -0.0818254066976014 0.470089439697841 no 1810 0.467392776096356 2546 735457 SGTC_433 pimozide 108 µM -0.0822134531395652 0.469937705426564 no 1811 0.467238487801728 2543 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3305 9127027 53.8275 µM -0.0830161966745028 0.469623829802506 no 1812 0.466919330492128 2600 41905295 SGTC_1984 st072354 53.1 µM -0.0833631407341208 0.469488179251323 no 1813 0.466781397947749 2578 5762938 SGTC_468 gf-109203x 121 µM -0.0833779898463555 0.469482373523214 no 1814 0.466775494560935 2550 2396 A protein kinase C inhibitor. SGTC_540 1187-0821 17.3 µM -0.0842612466852795 0.469137048157934 no 1815 0.466424361725842 2568 847520 SGTC_849 0386-0493 241 µM -0.0845966843622321 0.469005908750727 no 1816 0.466291017557928 2558 726119 SGTC_1611 st001856 99.4 µM -0.0858768947024571 0.468505441365323 no 1817 0.465782139500217 2568 647478 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.0863287035132736 0.468328829437498 no 1818 0.465602560770438 2586 115019 SGTC_664 1222-0054 14.9 µM -0.0895233942480964 0.467080205644931 no 1819 0.46433298115231 2590 6813991 SGTC_2497 7-hydroxyflavone 100 µM -0.0899282652558072 0.466921987352038 no 1820 0.46417210986064 2717 5281894 SGTC_2036 5160441 105 µM -0.0900890394187897 0.46685916036097 no 1821 0.464108229539354 2591 134534 YIL048W NEO1 SGTC_1065 prochlorperazine maleate 2.48 µM -0.0911221312922791 0.466455470647046 no 1822 0.463697773784177 2563 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1247 0448-0043 5.84 µM -0.0927928200138923 0.465802707575174 no 1823 0.463034077599639 2651 3089013 YGL099W LSG1 SGTC_3340 9146634 11.102 µM -0.093439292131091 0.465550145839286 no 1824 0.462777288219075 2615 4907387 SGTC_3321 9137793 26.8275 µM -0.0950253783864064 0.464930557535014 no 1825 0.46214733454557 2577 4904192 SGTC_2852 9023854 51.95 µM -0.0956471660702649 0.464687685677314 no 1826 0.461900401892795 2674 19798528 SGTC_183 3914-0051 30.55 µM -0.0958098611678587 0.4646241387244 no 1827 0.461835792656728 2628 1596232 SGTC_2532 xanthone 78.9 µM -0.0963682322636866 0.464406051860226 no 1828 0.461614060824425 2644 7020 An insecticide. SGTC_1705 st027868 56.3335 µM -0.097305602574179 0.46403996072576 no 1829 0.461241853452993 2657 292948 SGTC_2910 7948405 25.97 µM -0.097357012976331 0.464019883207429 no 1830 0.461221440588726 2623 2971328 SGTC_1166 k206-0078 225 µM -0.0980290155271233 0.463757451699582 no 1831 0.460954626632603 2565 5404595 SGTC_2496 diffractaic acid 79.83 µM -0.0981993427546323 0.463690937739493 no 1832 0.460887002174485 2612 94870 An apoptosis inducer which activates caspases. SGTC_2935 9038016 29.96 µM -0.0983900505727899 0.463616466222229 no 1833 0.460811287419869 2603 6463195 SGTC_2589 lobaric acid 100 µM -0.0984815032279372 0.463580754357705 no 1834 0.460774979420922 2633 73157 A novel microtubule depolymerizer. SGTC_323 4013-0906 34.3 µM -0.0986019909922025 0.463533704857266 no 1835 0.460727144571817 2689 2910086 SGTC_894 0960-0238 55.9 µM -0.0992759287182337 0.463270547032777 no 1836 0.460459595043657 2549 6741907 YDL195W SEC31 SGTC_1277 0873-0036 22 µM -0.101087887936608 0.462563096917236 no 1837 0.459740346409157 2667 5965735 SGTC_2709 st078560 56 µM -0.101314563274706 0.462474603491358 no 1838 0.45965037792925 2623 17250903 SGTC_1221 2958-7315 257 µM -0.101644815983043 0.462345677071675 no 1839 0.459519302815952 2668 4562705 SGTC_2606 farnesol 9.78 µM -0.103052655000393 0.461796119324978 no 1840 0.458960590360884 2659 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_83 0170-0301 39.027 µM -0.103131950485358 0.461765168053722 no 1841 0.458929123698576 2577 3089716 SGTC_37 0566-0070 1.56 µM -0.103295078580174 0.461701495271382 no 1842 0.458864390725569 2686 1626686 SGTC_1656 st012921 11 µM -0.103424709559371 0.461650897911297 no 1843 0.458812950954749 2667 6732821 SGTC_3301 9125354 19.7965 µM -0.103705238120571 0.461541404570182 no 1844 0.4587016348267 2590 41905162 SGTC_1451 4152-0210 104 µM -0.104158306683426 0.461364573153606 no 1845 0.45852186019531 2577 659563 SGTC_2643 anethole 100 µM -0.104188060282542 0.46135296067243 no 1846 0.458510054458968 2594 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_953 1188-0045 9.7 µM -0.105186151077414 0.460963436681825 no 1847 0.458114049798639 2689 6144426 SGTC_1851 st056236 18.9 µM -0.105212787753552 0.460953041721772 no 1848 0.458103481941267 2593 5393171 SGTC_1359 1582-0056 520 nM -0.10527236052496 0.460929793550587 no 1849 0.45807984709686 2688 3661189 SGTC_61 0978-8327 98.565 µM -0.107122718182136 0.460207761550001 no 1850 0.457345812182558 2605 6150059 YHR072W ERG7 SGTC_935 2996-0153 430 µM -0.107917616299624 0.459897622809968 no 1851 0.457030521473247 2604 23738523 SGTC_1034 k072-0165 12.7 µM -0.108474547998843 0.459680343958514 no 1852 0.456809634559567 2620 5835461 SGTC_1963 st076565 50.3 µM -0.108512447295619 0.459665558532609 no 1853 0.456794603651718 2605 4914280 SGTC_1864 st057645 30.4 µM -0.111203260169838 0.458615951589497 no 1854 0.45572758321409 2607 688666 SGTC_1177 0983-0204 23.6 µM -0.112008432959147 0.458301933112064 no 1855 0.45540836005799 2672 766818 SGTC_639 0833-0042 114 µM -0.112472249338416 0.458121055896463 no 1856 0.455224485964216 2628 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1128 3448-9350 235 µM -0.113720432880269 0.457634337556135 no 1857 0.454729707251086 2714 619386 SGTC_1218 1348-1416 30.7 µM -0.11395152354097 0.457544232706526 no 1858 0.454638110825061 2598 6787668 SGTC_1307 1187-1599 12.2 µM -0.115142080309969 0.457080055904203 no 1859 0.454166253211736 2613 1538471 SGTC_1279 0874-0590 65.2 µM -0.115776824217251 0.456832604489828 no 1860 0.453914709285925 2676 3523074 SGTC_58 0957-0393 9 µM -0.12008506653145 0.455153507151093 no 1861 0.452207880981633 2618 6997992 SGTC_1000 4048-0884 8.67 µM -0.120095464859181 0.455149455456437 no 1862 0.452203762454411 2743 13040088 SGTC_262 fenpropimorph 62.5 µM -0.12093340245831 0.454822969551141 no 1863 0.451871892493805 2627 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.124156117530324 0.453567588304865 no 1864 0.450595833233888 2634 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1891 st059073 26.2 µM -0.124168851378616 0.45356262885431 no 1865 0.450590792170884 2733 688754 SGTC_432 NS 1619 61.3 µM -0.124482983872732 0.453440285999691 no 1866 0.450466436241946 2788 4552 A K+/calcium channel activator. SGTC_2146 5545642 200 µM -0.124842426760076 0.453300301863338 no 1867 0.450324149210723 2636 825326 SGTC_597 k018-0003 82.8 µM -0.125347715671381 0.453103528172324 no 1868 0.450124139196745 2740 6786234 SGTC_2337 9009472 200 µM -0.126087209320315 0.452815569350183 no 1869 0.449831446073863 2683 5742383 SGTC_2225 6654152 15.4 µM -0.12626161575457 0.452747659096271 no 1870 0.449762419615971 2619 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_212 3807-4682 38.772 µM -0.128848476838323 0.451740552306088 no 1871 0.448738773116625 2705 3125501 YBL034C STU1 SGTC_1737 st035557 69.7 µM -0.129974271657227 0.451302358790194 no 1872 0.448293391119762 2600 5716916 SGTC_1552 6-methylflavone 10.6 µM -0.130790985495088 0.450984506078394 no 1873 0.447970327135141 2639 689013 SGTC_1039 k821-0043 94 µM -0.133892471986343 0.449777742297506 no 1874 0.446743801584936 2640 15992768 SGTC_985 1493-0307 8.71 µM -0.134100516417356 0.449696810353285 no 1875 0.446661545645229 2692 3278274 SGTC_1073 triclabendazole 3.09 µM -0.134542292768601 0.449524960645973 no 1876 0.446486885143374 2696 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1372 2752-0194 270 µM -0.134628473237682 0.449491437798272 no 1877 0.446452814080463 2632 823334 SGTC_2796 7949634 45.45 µM -0.135380359598741 0.449198981141644 no 1878 0.446155575967613 2635 2971588 SGTC_337 1315-0038 354 µM -0.135478811297841 0.449160689024048 no 1879 0.446116657964694 2676 1626437 SGTC_938 3126-1755 342 µM -0.135485620926963 0.449158040482699 no 1880 0.446113966134291 2670 1777771 SGTC_2616 abietic acid 100 µM -0.136438236598176 0.448787551934761 no 1881 0.445737423926792 2682 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1298 1079-1278 263 µM -0.13699267515235 0.448571941823161 no 1882 0.445518292453599 2676 2840950 SGTC_3113 9123498 49.47 µM -0.13703268260093 0.448556384309982 no 1883 0.44550248090051 2625 8897275 SGTC_2594 a-mangostin 100 µM -0.137437793852649 0.448398855014402 no 1884 0.445342379650162 2780 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2320 7373003 200 µM -0.137797272125195 0.448259077116 no 1885 0.445200320161207 2697 5415828 SGTC_2438 5259590 200 µM -0.138208800665663 0.44809906811478 no 1886 0.445037699962009 2764 1201127 SGTC_2266 7929956 200 µM -0.138405343483205 0.448022652043037 no 1887 0.444960037086488 2631 2967153 SGTC_476 mead acid 10 µM -0.139509209873574 0.447593503449123 no 1888 0.444523889341356 2659 5312531 An omega 9 fatty acid. SGTC_1740 st038286 13.222 µM -0.139743809162233 0.44750230649812 no 1889 0.444431205644465 2833 716786 SGTC_1687 st020778 55.3625 µM -0.141313358368068 0.446892239439099 no 1890 0.443811198530679 2673 4259299 SGTC_2737 bleomycin 30.5 nM -0.141476325637029 0.446828902973489 no 1891 0.443746830660924 2670 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_24 0417-1663 219 µM -0.142218597315399 0.446540439743232 no 1892 0.44345367128313 2723 4329390 SGTC_980 1473-0395 201 µM -0.142642893271868 0.446375561623915 no 1893 0.44328610995487 2663 768876 SGTC_1637 st007924 17.4 µM -0.142719268443831 0.446345883807935 no 1894 0.443255949241666 2641 683336 SGTC_1805 st050013 60.3 µM -0.143516566439942 0.446036088233151 no 1895 0.44294111427762 2733 4037144 SGTC_786 4544-0069 423 µM -0.143884519877077 0.445893128512573 no 1896 0.442795829915667 2784 748821 YLR208W SEC13 SGTC_153 4077-0274 519.67 µM -0.144286617309024 0.445736910983551 no 1897 0.442637072783795 2698 3121976 SGTC_738 1315-0003 72.4 µM -0.14506969259929 0.445432705219088 no 1898 0.442327923461132 2782 6251474 SGTC_2139 5578692 56.4705 µM -0.145085457746138 0.445426581171065 no 1899 0.442321699918354 2686 650991 YMR113W FOL3 SGTC_279 1273-0055 2.93 µM -0.145229691455781 0.445370553489312 no 1900 0.442264762025609 2735 2847562 SGTC_2157 5649910 96.377 µM -0.145300675346875 0.445342980149516 no 1901 0.442236740767365 2680 2858091 SGTC_2053 5265679 138 µM -0.145618906670078 0.445219368024858 no 1902 0.44211112086032 2673 764595 SGTC_2960 9079389 5.97 µM -0.145708715440123 0.445184484135132 no 1903 0.442075670439417 2754 16457355 SGTC_1213 1315-0166 115 µM -0.150134759638656 0.443465833177287 no 1904 0.44032914827511 2808 768401 SGTC_2433 5607874 27.82 µM -0.150330474938795 0.443389860433098 no 1905 0.44025194533053 2666 2252428 SGTC_2743 auranofin 4.32 µM -0.150345254245316 0.443384123487946 no 1906 0.440246115495377 2713 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3243 9134147 49.47 µM -0.15069401455221 0.443248747189486 no 1907 0.440108547505299 2685 24282180 SGTC_202 3594-0513 34.79 µM -0.151661571696754 0.442873210780602 no 1908 0.43972693391482 2650 708429 SGTC_2568 diosmetin 100 µM -0.152043042533648 0.442725165199502 no 1909 0.43957649361842 2671 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3224 9130643 49.47 µM -0.152354439152743 0.442604320752558 no 1910 0.439453694892954 2836 17644395 SGTC_2541 muurolladie-3-one 83.07 µM -0.152365505842814 0.44260002617329 no 1911 0.439449330869736 2845 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2641 levomentholum 100 µM -0.15240068546292 0.442586374289087 no 1912 0.439435458236001 2671 16666 SGTC_312 4092-0653 6.84 µM -0.152863025562413 0.442406963869266 no 1913 0.439253147242779 2769 1148278 SGTC_815 1582-0027 36.9 µM -0.153517796626444 0.442152901103223 no 1914 0.43899497848983 2752 3128206 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.155358857797132 0.441438664603677 no 1915 0.43826920850593 2658 756377 SGTC_1400 3771-8998 51.5 µM -0.156899678691708 0.44084105205224 no 1916 0.4376619565445 2707 670767 SGTC_1718 roemerine 11.9335 µM -0.15716759085542 0.440737155129684 no 1917 0.437556384789691 2777 235224 An aporphine alkaloid with mutagenic activity. SGTC_2268 7933382 153.85 µM -0.157439984947482 0.440631524287786 no 1918 0.437449051472282 2656 935025 YOR257W CDC31 SGTC_80 0159-0065 512.242 µM -0.159013173073627 0.440021545529986 no 1919 0.436829247636516 2645 1548079 SGTC_344 k064-0035 6.43 µM -0.160851791892162 0.439308830706771 no 1920 0.436105066132808 2702 5088750 SGTC_3279 9140807 49.47 µM -0.160977904334888 0.439259952167516 no 1921 0.436055401722631 2675 45595718 SGTC_1103 duloxetine 36.1 µM -0.161833827573121 0.438928238770974 no 1922 0.435718356805259 2861 60835 A selective serotonin reuptake inhibitor. SGTC_2108 5365811 200 µM -0.162895248675219 0.438516944187981 no 1923 0.435300455935359 2793 780283 SGTC_3308 9128332 17.569 µM -0.163454853218283 0.438300127340719 no 1924 0.435080158465968 2844 17332805 YDL196W YDL196W SGTC_194 1486-1323 56.904 µM -0.164525351906942 0.437885417969834 no 1925 0.434658795368398 2718 5178754 SGTC_1067 clotrimazole 1.36 µM -0.165858120209292 0.437369201175187 no 1926 0.434134303078221 2709 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_247 mechlorethamine 29.705 µM -0.166507451442819 0.437117736393048 no 1927 0.433878809812434 2693 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2257 7960413 200 µM -0.166982177298153 0.436933906640801 no 1928 0.43369203624163 2715 2974689 YIL048W NEO1 SGTC_3219 9131112 49.47 µM -0.168112198833626 0.436496379307174 no 1929 0.433247506326005 2737 17612988 YMR079W SEC14 SGTC_1703 st026983 48.3 µM -0.171197514005148 0.435302188827001 no 1930 0.432034231087922 2823 1104023 SGTC_2043 5101342 149 µM -0.173007237733056 0.434601997708734 no 1931 0.431322869262709 2733 678451 SGTC_2890 9046729 58.44 µM -0.173241762199513 0.434511273989005 no 1932 0.431230699203966 2759 903329 SGTC_2670 beta-carotene 100 µM -0.173474355056955 0.434421300901258 no 1933 0.431139291982163 2757 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2722 naftopidil 47.16 µM -0.17622955904611 0.433355774582004 no 1934 0.430056799712327 2724 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_51 1013-0126 23.419 µM -0.177007164664064 0.433055136672972 no 1935 0.429751380928249 2880 1627850 SGTC_807 1315-0151 48 µM -0.177105222359756 0.433017228350565 no 1936 0.429712869961338 2858 4011080 SGTC_2740 felodipine 17.08 µM -0.17720938503919 0.43297696056531 no 1937 0.4296719620689 2818 3333 L-type calcium channel blocker SGTC_754 3474-0146 171 µM -0.177901291012849 0.432709497407719 no 1938 0.429400248469381 2704 24762078 SGTC_258 haloperidol 50.781 µM -0.179544957508028 0.432074245541871 no 1939 0.428754909912502 2745 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3093 9117344 49.47 µM -0.17971272377466 0.432009416303149 no 1940 0.428689051975919 2871 24824913 SGTC_2379 9035213 200 µM -0.180050779392372 0.431878788403669 no 1941 0.428556351680003 2825 646551 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.181071975406786 0.431484233858492 no 1942 0.42815554067709 2867 61125 An anti-inflammatory. SGTC_761 k216-0224 480 µM -0.181524743291224 0.431309321976492 no 1943 0.427977856709598 2759 1340404 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.183114107898842 0.430695430432012 no 1944 0.427354243215447 2698 1241132 A phosphatase inhibitor. SGTC_1153 4055-0057 267 µM -0.183571889407965 0.430518643471299 no 1945 0.427174658662021 2733 882706 SGTC_2290 7904846 200 µM -0.184429273717144 0.43018757460703 no 1946 0.426838353292956 2820 2962154 SGTC_2744 captopril 92.04 µM -0.187047968327405 0.429176701287313 no 1947 0.425811511648709 2807 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_3023 9089636 49.47 µM -0.187962706281666 0.428823701536073 no 1948 0.425452943067256 2736 17249241 SGTC_2 0422-0095 29 µM -0.188039342956037 0.428794129825027 no 1949 0.425422905014178 2700 6790840 SGTC_2220 6782180 200 µM -0.188341339461508 0.428677602651234 no 1950 0.425304540483347 2745 833803 SGTC_422 cantharidin 155 µM -0.188980779155249 0.428430891517785 no 1951 0.425053940677656 2710 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2258 7960471 200 µM -0.189094576745443 0.428386988613452 no 1952 0.425009345969977 2796 2974708 SGTC_1590 st077108 57.8 µM -0.189261761792693 0.428322490532484 no 1953 0.424943831663247 2732 5489485 SGTC_424 splitomicin 100 mM -0.189597343639058 0.428193032670887 no 1954 0.424812334462459 2822 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2945 9067681 61.76 µM -0.190130413768668 0.42798740538093 no 1955 0.424603469005111 2685 16456930 SGTC_1849 st056239 19.2 µM -0.190735812383816 0.427753901706952 no 1956 0.424366289757125 2745 5393181 SGTC_2657 nystatin 74.44 µM -0.190829985936123 0.42771758101759 no 1957 0.424329397496487 2784 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1225 1216-0074 20.6 µM -0.191006926929824 0.427649340384397 no 1958 0.424260083084822 2764 4241466 SGTC_1453 4237-0541 195 µM -0.191175183019104 0.427584451256014 no 1959 0.424194173048263 2810 739892 SGTC_438 sphingosine 6.67 µM -0.191720647598975 0.427374102532651 no 1960 0.423980515781413 2744 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1347 1493-0251 600 nM -0.191749563125646 0.427362952349249 no 1961 0.423969190256759 2878 3986378 SGTC_2687 chenodiol 100 µM -0.191898662449068 0.42730545873398 no 1962 0.423910792591839 2840 5702181 A cholesterol synthesis inhibitor. SGTC_2373 9071805 200 µM -0.194919511746155 0.42614093485814 no 1963 0.422727979497747 2806 10149009 SGTC_518 1021-0119 62.6 µM -0.197572848508331 0.425118616071624 no 1964 0.421689639889708 2809 1097762 SGTC_2309 7664088 163.95 µM -0.198647857563431 0.424704562778458 no 1965 0.421269107321139 2873 704922 SGTC_2297 7971671 152.32 µM -0.198900182373998 0.424607388715704 no 1966 0.421170413425479 2914 909016 SGTC_910 3454-3003 490 µM -0.199278701439664 0.424461623949799 no 1967 0.42102236941445 2818 820824 SGTC_2047 4141938 200 µM -0.200250543207723 0.424087422555575 no 1968 0.420642319925625 2778 3807862 SGTC_1460 k062-0059 9.15 µM -0.201325911707409 0.423673438625486 no 1969 0.420221871367614 2673 1373085 SGTC_851 0394-0702 453 µM -0.201918543244298 0.423445329608906 no 1970 0.419990202619156 2847 762646 SGTC_1219 1469-0211 33.1 µM -0.202128481279394 0.423364528789107 no 1971 0.419908141269712 2856 6822282 SGTC_3330 9141424 71.43 µM -0.202197853439793 0.423337829583613 no 1972 0.419881025590385 2890 27261020 SGTC_2941 9056145 11.23 µM -0.203700884422652 0.422759445942745 no 1973 0.419293625509232 2733 2119517 SGTC_1346 1488-2224 62.4 µM -0.204271763587239 0.422539808616405 no 1974 0.419070567066944 2790 3722427 SGTC_317 4495-0002 170 µM -0.204279951166669 0.422536658741157 no 1975 0.419067368139896 2804 15991618 SGTC_2067 5224629 34.075 µM -0.204358703859414 0.422506361742104 no 1976 0.419036599353622 2921 2835000 SGTC_2847 9005661 71.43 µM -0.204683179810001 0.42238153722828 no 1977 0.418909831374953 2761 2991449 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.204697386556963 0.422376072131363 no 1978 0.418904281200275 2965 688798 SGTC_1334 1486-0610 236 µM -0.204717580489326 0.422368303890512 no 1979 0.418896392029185 2866 3742339 SGTC_1385 3091-4834 14.1 µM -0.204980317129953 0.422267236606158 no 1980 0.418793751581483 2879 4072814 SGTC_2249 haloperidol 116.36 µM -0.205004680043078 0.422257865148254 no 1981 0.418784234268811 2751 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2956 9076196 2.52 µM -0.205120496567983 0.422213315671956 no 1982 0.418738991475629 2874 16423868 SGTC_1653 st012112 65 µM -0.206906445278714 0.421526466811088 no 1983 0.41804146141666 2928 720429 SGTC_716 1683-5115 658 µM -0.20768988987618 0.421225241064895 no 1984 0.417735556132582 2746 723597 SGTC_669 0108-0021 26.2 µM -0.208435308436483 0.420938678704444 no 1985 0.417444544771309 2754 17201 SGTC_2168 5727979 200 µM -0.208993565814215 0.420724094415171 no 1986 0.417226630724859 2717 695210 SGTC_2419 paclitaxel 166.5 µM -0.209482172497984 0.420536301950525 no 1987 0.417035925472929 2714 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2011 4012611 177 µM -0.210408193518213 0.420180442080554 no 1988 0.416674549144227 2774 2049887 SGTC_1477 0139-0234 16 µM -0.210582054590079 0.420113636415307 no 1989 0.41660670833569 2763 620880 SGTC_2534 helenine 20.12 µM -0.210592600490758 0.420109584254383 no 1990 0.416602593391882 2763 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2778 tioconazole 65.09 nM -0.215551521742813 0.418205111908259 no 1991 0.414668673713828 2748 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_552 k242-0005 476 µM -0.217002628746843 0.417648175066 no 1992 0.414103148154824 2904 4088318 SGTC_393 acivicin 6.25 µM -0.217453944173715 0.417474993207205 no 1993 0.413927297710801 2797 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_252 miconazole 1.30953 nM -0.217796366578408 0.41734360720508 no 1994 0.413793887832042 2878 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_426 0988-0037 14.6 µM -0.220165676706795 0.416434766717056 no 1995 0.412871063395441 2835 5383008 SGTC_1714 st033236 13.627 µM -0.220477771907666 0.416315083720134 no 1996 0.41274954095945 2946 2916566 SGTC_3012 9080433 71.4286 µM -0.220611801909773 0.41626368796254 no 1997 0.412697355435588 2878 17688859 SGTC_454 lyso-paf C-16 6.67 µM -0.223161546058239 0.415286225082539 no 1998 0.411704889529535 2870 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1832 st054113 55 µM -0.224330672565581 0.414838206842919 no 1999 0.411250005536527 2885 1251267 SGTC_2879 9041815 71.43 µM -0.225725549844385 0.41430382410122 no 2000 0.410707442495883 2858 4942971 SGTC_2787 5284540 71.43 µM -0.225801223808307 0.414274837647101 no 2001 0.410678012598459 2894 736958 SGTC_1345 1488-0192 31.4 µM -0.227651299833166 0.413566322835235 no 2002 0.409958667692968 2927 658348 SGTC_3042 9091578 49.47 µM -0.228199166028674 0.413356563011861 no 2003 0.409745704874904 2804 25236497 SGTC_366 0181-0206 4.31 µM -0.228444139442549 0.413262778800829 no 2004 0.409650489087157 2971 274874 SGTC_345 1362-0200 395 µM -0.229398752487604 0.412897367505772 no 2005 0.409279502842119 2830 1419823 SGTC_2677 mitomycin C 100 µM -0.230224864432643 0.412581205362993 no 2006 0.408958520858029 2829 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3353 9151644 39.2805 µM -0.231093475173513 0.412248839625521 no 2007 0.4086210920002 2933 4909158 SGTC_1052 3253-3998 198 µM -0.232555077586147 0.411689713337304 no 2008 0.408053456895629 2773 5450317 SGTC_1294 1000-1494 117 µM -0.23276124577957 0.411610859466218 no 2009 0.407973403899768 2833 712797 YDL207W GLE1 SGTC_1938 st074717 56.4 µM -0.234631640320531 0.410895646590624 no 2010 0.407247324781434 2780 17250979 SGTC_548 1436-0017 110 µM -0.234759833454257 0.410846638134686 no 2011 0.407197572396259 2943 9677137 SGTC_2698 st077697 67.5 µM -0.234888443191724 0.410797471808895 no 2012 0.407147659829689 2870 3154499 SGTC_1474 0330-0125 5.35 µM -0.23532529429388 0.410630478099601 no 2013 0.406978132144298 2857 X1474 SGTC_1276 0871-0068 94.2 µM -0.235703306887243 0.410485989475984 no 2014 0.406831451831001 2919 3414906 SGTC_1047 2043-3044 82 µM -0.236610317376011 0.410139350349839 no 2015 0.40647955767797 2829 669592 SGTC_3233 9132340 49.47 µM -0.237106384613757 0.409949794225167 no 2016 0.406287129689974 2845 17682950 SGTC_1288 0973-0013 65.5 µM -0.237701651983417 0.409722359741939 no 2017 0.40605625114699 2908 4315430 SGTC_2928 9011484 9.79 µM -0.238236949051346 0.409517864115397 no 2018 0.405848660391172 2959 2994751 SGTC_2638 epoxomicin 18 µM -0.238643218568776 0.409362676368379 no 2019 0.405691124801498 2936 9915668 A protesome inhibitor. SGTC_1859 st055998 20 µM -0.238675666561619 0.409350282422993 no 2020 0.405678543384431 2986 676301 SGTC_627 1391-0720 175 µM -0.238883936278135 0.409270733173489 no 2021 0.405597790997432 2908 997839 SGTC_1116 jasmonic acid  1.58368 µM -0.239442864224531 0.40905726742552 no 2022 0.405381097813083 2986 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_460 trequinsin 123 µM -0.239755798061874 0.40893776351415 no 2023 0.405259787803824 2903 5537 A vasodilator. SGTC_1688 st021091 57.6 µM -0.239875807820091 0.408891936149697 no 2024 0.405213267971907 2915 3656366 SGTC_988 1497-1057 103 µM -0.240420863586905 0.408683814847168 no 2025 0.405002002826602 2828 3533044 SGTC_60 0986-0278 202 µM -0.240612430495977 0.408610674031677 no 2026 0.404927757526393 2830 3110598 SGTC_165 k038-0023 64.381 µM -0.241507825320432 0.408268851872311 no 2027 0.404580776115243 2843 46368543 SGTC_139 0099-0334 718.624 µM -0.242444406280606 0.407911381347767 no 2028 0.404217914629323 2808 97690 SGTC_322 k048-0136 19.3 µM -0.242780268380693 0.407783209482053 no 2029 0.404087810939237 2925 6823282 SGTC_181 1447-1644 8.07 µM -0.243217241435597 0.407616466377263 no 2030 0.403918555542783 2933 534600 SGTC_2078 5212016 200 µM -0.243392444113312 0.407549616064525 no 2031 0.403850698287995 2809 1899708 SGTC_534 k292-0788 63.4 µM -0.244038823414436 0.407303006957846 no 2032 0.40360037598982 2968 4146317 SGTC_1594 piperine 70.1 µM -0.244204477722901 0.407239811801778 no 2033 0.403536229657659 2811 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3190 9110366 49.47 µM -0.245119742998249 0.406890692509578 no 2034 0.403181858227245 2926 17123768 SGTC_575 k072-0246 11.9 µM -0.246182672043916 0.406485341123611 no 2035 0.402770414281437 2824 6796779 SGTC_2686 alizarin 95.37 µM -0.248256908970564 0.405694613141654 no 2036 0.401967818577682 2907 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_126 0417-1624 672.48 µM -0.249143856306315 0.405356613688447 no 2037 0.401624753176503 2926 41912 YDL195W SEC31 SGTC_1630 st005209 31.3 µM -0.249298117144288 0.405297834893715 no 2038 0.401565093829218 2843 3367314 SGTC_2459 5811157 9.22 µM -0.249890402785628 0.40507217312668 no 2039 0.401336052646045 2829 2870684 YBR192W RIM2 SGTC_2041 5107442 45.335 µM -0.252810887399864 0.403959926706107 no 2040 0.40020717700804 3007 793005 SGTC_259 usnic acid 108.925 µM -0.253139389587404 0.403834867302549 no 2041 0.400080250689475 3048 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2079 5212404 121 µM -0.253278136814627 0.403782049767566 no 2042 0.400026644856001 2965 758462 SGTC_781 4335-2806 94.4 µM -0.254406244857125 0.40335267297784 no 2043 0.399590863474906 3026 845254 SGTC_2317 5986382 200 µM -0.254632893147474 0.403266420883321 no 2044 0.399503325666727 2919 877883 SGTC_2253 7938677 135.83 µM -0.255071852202123 0.403099386294399 no 2045 0.399333801968009 3054 2301972 SGTC_1010 4112-3296 15.2 µM -0.255324304756114 0.403003329967962 no 2046 0.399236314702359 3014 704384 SGTC_900 1112-0045 141 µM -0.2553680138936 0.402986699559276 no 2047 0.399219436587361 2877 56211 YIL048W NEO1 SGTC_216 k038-0035 28.382 µM -0.256775147067752 0.40245140886968 no 2048 0.398676178358594 2936 4444231 YPR107C YTH1 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.25804225469274 0.401969542042417 no 2049 0.398187148324923 2910 2374 Ca(2+)-ATPase inhibitor. SGTC_1771 st048882 4.1505 µM -0.258599387818787 0.401757717666558 no 2050 0.39797217781658 2843 4580403 SGTC_2431 5490079 200 µM -0.259933650965246 0.401250542590069 no 2051 0.397457476738209 2915 5722345 SGTC_2563 tomatine 8.54 µM -0.260704521142726 0.400957598082672 no 2052 0.397160189617616 2969 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_998 3996-0085 177 µM -0.261182785738401 0.400775876928006 no 2053 0.396975776252109 2933 715391 SGTC_2086 5274770 176.623 µM -0.262581714427012 0.400244464129733 no 2054 0.396436497698403 2946 689278 SGTC_939 1165-0479 45.3 µM -0.262700751204248 0.400199253989989 no 2055 0.396390618870018 2982 1377347 SGTC_42 0133-0086 60.653 µM -0.264075383301917 0.399677266089806 no 2056 0.395860916032432 2823 162923 Model of phenazepam hydroxylation. SGTC_2747 doxorubicin 7.63 µM -0.264461646338898 0.399530622969416 no 2057 0.395712107402527 2892 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1211 1056-0033 32.3 µM -0.265037508151215 0.399312025799965 no 2058 0.395490283683642 2994 6741922 SGTC_1377 2944-0135 198 µM -0.26538002765663 0.399182020347352 no 2059 0.395358360181791 2955 1894137 SGTC_1497 4476-2978 41.3 µM -0.266304776109039 0.398831082084014 no 2060 0.395002247536716 2953 1528379 SGTC_607 4491-0986 66.8 µM -0.267542649747095 0.398361442128641 no 2061 0.394525690387238 3024 698981 YDR232W HEM1 SGTC_2780 5215298 71.43 µM -0.269161822306366 0.397747362480597 no 2062 0.393902578911847 3024 2834131 SGTC_1169 aniline yellow 25.8 µM -0.269363007682341 0.397671079535066 no 2063 0.39382517501759 2921 6051 A DNA damaging agent. SGTC_2387 9077560 195.08 µM -0.269378294716142 0.397665283349386 no 2064 0.393819293668351 2877 5303272 SGTC_3273 9137859 49.47 µM -0.2697722140266 0.397515933885347 no 2065 0.393667750254428 2919 2377234 SGTC_25 0118-0223 35.662 µM -0.270462012322328 0.397254441887689 no 2066 0.393402419002985 3038 5333628 SGTC_1268 0828-0275 2.46 µM -0.271063984838481 0.397026281028003 no 2067 0.393170910421442 2986 745337 SGTC_1021 4476-0760 85.3 µM -0.271243798065467 0.396958134681227 no 2068 0.393101764578937 2900 746768 SGTC_1912 st060209 90.8 µM -0.272077551764219 0.396642196466982 no 2069 0.392781194883134 2955 688787 SGTC_2203 7227154 166.4 µM -0.274267673143717 0.395812607133705 no 2070 0.391939462701602 2887 896304 SGTC_2338 7999974 200 µM -0.275098727178137 0.395497937994005 no 2071 0.391620194717372 2952 315925 SGTC_1570 verbenone 133 µM -0.277309457405197 0.394661202305337 no 2072 0.390771249135254 3087 29025 A natural terpanoid with antifungal properties. SGTC_2997 9067075 71.4286 µM -0.279630210078151 0.393783346988891 no 2073 0.389880613525871 3007 27209819 SGTC_2366 9070441 60.58 µM -0.279676582387843 0.393765811534072 no 2074 0.3898628230907 2908 6837235 SGTC_2999 9069765 71.4286 µM -0.280491102479363 0.393457840025859 no 2075 0.389550375402637 2987 2097066 SGTC_1452 4194-0072 190 µM -0.281097955564986 0.393228431097994 no 2076 0.389317634600518 3060 1343545 SGTC_2156 5649887 115 µM -0.281396531440696 0.393115573934823 no 2077 0.389203139097428 3001 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_528 3492-0019 172 µM -0.281585899459603 0.393044000343553 no 2078 0.389130526739629 2974 2869262 SGTC_1561 5-methoxyflavone 52.9 µM -0.284365777861132 0.391993734001478 no 2079 0.388065041100672 2896 94525 SGTC_920 mycophenolic acid 780.421 nM -0.285592053478118 0.391530684125974 no 2080 0.387595295243418 2942 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1178 0988-0033 191 µM -0.286178454946989 0.391309309274268 no 2081 0.387370722221309 3047 5392207 SGTC_550 4123-0385 25.7 µM -0.286271385223488 0.391274230009641 no 2082 0.387335136352662 2912 5731123 SGTC_2949 9072542 2.23 µM -0.287129487149775 0.390950356032892 no 2083 0.387006587429359 3015 16457352 SGTC_2228 7354201 200 µM -0.287549888946981 0.390791711089597 no 2084 0.38684565407586 2939 753451 SGTC_1406 3909-7906 11.9 µM -0.289227050904964 0.390158989921829 no 2085 0.386203816202735 2960 X1406 SGTC_3091 9116372 49.47 µM -0.290350771898434 0.38973522087859 no 2086 0.38577395026593 3073 17169793 SGTC_1165 k072-0275 30.3 µM -0.290603508663012 0.389639928762008 no 2087 0.385677288158304 3018 6153523 YGL055W OLE1 SGTC_1088 bifonazole 369 nM -0.291114429099824 0.389447311088599 no 2088 0.385481902397664 2951 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2447 5741742 33.78 µM -0.291874302766103 0.389160887964076 no 2089 0.385191365915346 3005 1776504 SGTC_2287 7945887 168.79 µM -0.292073347736013 0.389085870857101 no 2090 0.385115272031886 3020 1245853 SGTC_2493 resveratrol 26.09 µM -0.293857821488476 0.388413514071798 no 2091 0.384433274688288 2890 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1982 st072467 71.9 µM -0.294068813288766 0.388334038311031 no 2092 0.384352660592442 2874 3163533 SGTC_3195 9113082 49.47 µM -0.294172899031596 0.388294833326393 no 2093 0.384312894168482 3005 17018038 SGTC_3292 9120825 59.784 µM -0.295563027821279 0.387771336023566 no 2094 0.383781906120952 3086 24824900 SGTC_278 4092-0821 23.9 µM -0.296306055002756 0.387491609024342 no 2095 0.383498181124447 2999 877900 SGTC_2178 5812956 200 µM -0.296403360467509 0.387454980815541 no 2096 0.383461029646202 2884 5403383 SGTC_1434 4073-0095 163 µM -0.296979989286255 0.387237943885251 no 2097 0.38324089327055 2954 24133745 SGTC_610 4215-0184 155 µM -0.297279037057129 0.387125399371763 no 2098 0.383126742306428 2979 5605015 SGTC_2836 9010338 19.48 µM -0.29803003679023 0.386842807785905 no 2099 0.382840119344641 2935 2994051 SGTC_2222 6885208 172.143 µM -0.299997302313736 0.386102835656507 no 2100 0.382089606676135 2963 609514 SGTC_2179 6298986 200 µM -0.300052560684939 0.386082056603211 no 2101 0.382068531964293 3078 738374 SGTC_1676 st018489 23.4 µM -0.301709429256597 0.385459168924707 no 2102 0.381436789780781 2951 3696235 SGTC_2757 clomiphene 4.22 µM -0.301788381983547 0.385429494580859 no 2103 0.381406694013323 3167 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2135 5326629 150.42 µM -0.302033627223003 0.385337323555544 no 2104 0.381313214245642 2984 5020077 SGTC_3188 9110789 49.47 µM -0.302360983477451 0.385214302670367 no 2105 0.38118844713333 3115 849217 SGTC_1435 4092-0789 56.7 µM -0.303275733476337 0.384870599760974 no 2106 0.380839868876365 3040 2248285 SGTC_1265 0819-1001 68.8 µM -0.303660373786357 0.384726104217536 no 2107 0.380693325177563 2942 3106768 SGTC_211 3455-0679 143.504 µM -0.304150796633198 0.384541893199385 no 2108 0.380506504329285 3029 748649 SGTC_2153 5569715 200 µM -0.304812449159027 0.384293406766804 no 2109 0.380254499700992 2955 2054701 SGTC_1436 4092-1007 8.32 µM -0.305650651132146 0.383978684712016 no 2110 0.379935325390913 2964 2881121 SGTC_3135 9127742 49.47 µM -0.305883955436457 0.383891098888617 no 2111 0.379846501267656 3001 3643468 SGTC_302 1094-0063 18.9 µM -0.306213517779094 0.383767386506468 no 2112 0.37972104037623 2923 5440289 SGTC_1115 galangin 695.678 nM -0.307906692288566 0.383131983154995 no 2113 0.379076666662613 3106 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_280 3448-3607 3.04 µM -0.310190684397124 0.382275359870744 no 2114 0.378207977088063 3052 626179 SGTC_1222 0366-0074 1.18 µM -0.310730344465484 0.382073041467487 no 2115 0.378002813422621 3068 286520 SGTC_570 0987-0065 62.6 µM -0.311010002762945 0.38196821031526 no 2116 0.377896508688149 2892 3104428 SGTC_569 4130-2812 160 µM -0.312090459871351 0.381563277545111 no 2117 0.377485888311999 2953 743552 SGTC_1603 st002045 67.8 µM -0.313253170180147 0.381127662761076 no 2118 0.377044162826364 3092 5887985 SGTC_1456 k015-0012 13 µM -0.314689685224196 0.380589673772754 no 2119 0.376498638329381 3160 2989616 SGTC_276 colchicine 750 µM -0.315214684109792 0.380393114079218 no 2120 0.376299328577427 3094 2833 A microtubule depolymerizer. SGTC_3352 9151559 45.5865 µM -0.315421559422481 0.380315668396921 no 2121 0.376220799814542 3040 17159339 SGTC_1154 4088-0362 150 µM -0.316313675854606 0.379981751367118 no 2122 0.375882215916399 2937 6618304 SGTC_107 0358-0022 2.6945 µM -0.317026015860204 0.379715188435767 no 2123 0.375611930935949 3041 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2684 capsaicin 100 µM -0.31956746505735 0.378764625721187 no 2124 0.374648120564821 3063 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_848 0368-0089 85.6 µM -0.320583687945533 0.378384738875999 no 2125 0.374262950400053 3090 762535 SGTC_2980 9014342 25.29 µM -0.32085441507806 0.378283554826927 no 2126 0.37416036018774 3128 2996599 SGTC_166 k072-0058 166.424 µM -0.324230255317562 0.377022540236373 no 2127 0.372881858909501 3091 5846229 SGTC_803 4488-1585 147 µM -0.324404696001914 0.376957414991832 no 2128 0.372815832466108 3107 747204 SGTC_2190 6049624 200 µM -0.325095882276957 0.376699403682828 no 2129 0.372554252656967 3059 2265554 SGTC_3100 9120536 49.47 µM -0.326325777389327 0.376240435240948 no 2130 0.372088943607025 2957 16421196 SGTC_846 0335-0850 148 µM -0.327772392036053 0.375700816025557 no 2131 0.371541881566107 3064 6819598 SGTC_3021 9087658 49.47 µM -0.327830027729449 0.375679321666361 no 2132 0.37152009100928 3077 25237042 SGTC_798 1287-0182 476 µM -0.328211660790973 0.375537007132488 no 2133 0.371375815865195 3175 1649755 SGTC_1142 3253-1408 9.78 µM -0.328377293750727 0.375475246322982 no 2134 0.371313204482839 3097 256655 SGTC_2195 6536160 144.242 µM -0.329088993700614 0.375209905735087 no 2135 0.371044211548739 2963 3834386 SGTC_1292 0kpi-0043 232 µM -0.330023885529635 0.374861443032469 no 2136 0.370690957125656 3030 3333905 SGTC_3041 9091929 49.47 µM -0.330067648366814 0.374845133788428 no 2137 0.370674423745889 3163 25236887 SGTC_2661 dactinomycin 12.96 µM -0.331370252620112 0.374359790471369 no 2138 0.370182415880432 3017 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.332243793292068 0.374034425367409 no 2139 0.369852588912019 2940 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2352 9027995 87.8 µM -0.33269641979527 0.373865872189103 no 2140 0.36968172616888 3040 2997347 SGTC_3345 9148410 3.559 µM -0.333271605918402 0.373651713944092 no 2141 0.36946463531249 3126 4903596 SGTC_3000 9075062 71.4286 µM -0.333504350185813 0.373565067678342 no 2142 0.369376803129804 3005 17057871 SGTC_1373 2887-0003 58.5 µM -0.334384879661581 0.373237321155036 no 2143 0.369044573847894 3053 776948 SGTC_2281 7943571 200 µM -0.334783118345314 0.37308912073246 no 2144 0.368894348006944 3216 1244024 SGTC_2305 7443522 69.23 µM -0.335106947578085 0.372968624860826 no 2145 0.368772206081384 2980 5415886 SGTC_835 0312-0010 67.2 µM -0.336734899020563 0.37236305756028 no 2146 0.368158376303432 2964 1626196 SGTC_1361 1608-0041 5.61 µM -0.336815996550817 0.372332899041634 no 2147 0.368127806731804 3004 X1361 SGTC_2946 9065502 71.43 µM -0.336948105436954 0.372283772116005 no 2148 0.36807801030724 3033 16489101 SGTC_1686 st019653 115.5 µM -0.337037685530282 0.372250461424323 no 2149 0.368044245721862 3124 97252 SGTC_251 melphalan 456.522 µM -0.337065103921749 0.372240265984279 no 2150 0.368033911368173 3058 460612 A DNA alkylator. SGTC_1559 coumarin 343 70.1 µM -0.337230981942568 0.372178586689614 no 2151 0.367971391789387 3156 108770 A hepatotoxic, DNA x-linker. SGTC_3226 9131256 49.47 µM -0.337502403658622 0.372077669602488 no 2152 0.367869100238246 3009 17178073 SGTC_1071 trifluoperazine 6.31 µM -0.338218170092722 0.371811583220461 no 2153 0.367599392056664 3149 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_930 2810-3379 265 µM -0.339172887351461 0.37145676210659 no 2154 0.367239746372881 3209 1015764 SGTC_525 k781-2675 26.7 µM -0.339588861309794 0.371302199328178 no 2155 0.367083083775799 3027 3651118 YDL195W SEC31 SGTC_18 0111-0177 500 nM -0.33963077409208 0.371286627013154 no 2156 0.367067299963141 3019 721752 SGTC_2304 7443016 91.4 µM -0.340982809530092 0.370784403641319 no 2157 0.366558261535027 2938 939854 SGTC_2152 5568786 200 µM -0.341448217496891 0.370611575347417 no 2158 0.366383090679595 3025 5399883 SGTC_2439 5492030 7.2 µM -0.341635844652293 0.37054190777027 no 2159 0.366312479197745 3109 5722370 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.344049702763626 0.369646000852823 no 2160 0.365404453852633 2985 6708630 An antioxidant. SGTC_2002 4023503 131 µM -0.344265690327803 0.369565871157391 no 2161 0.365323242094782 3155 4736863 YCR052W RSC6 SGTC_3191 9110352 49.47 µM -0.345186124698637 0.369224460757338 no 2162 0.364977224660853 3051 17122424 SGTC_1395 3486-0190 4.35 µM -0.346890601847043 0.368592503235582 no 2163 0.364336753707296 3186 6748079 SGTC_1493 4348-0038 111 µM -0.347743878219477 0.368276273016287 no 2164 0.364016270364315 3092 800424 SGTC_3235 9132602 49.47 µM -0.347994301885827 0.368183481170806 no 2165 0.363922231404594 3133 4912240 SGTC_2972 9093619 59.92 µM -0.348726879349909 0.367912076493167 no 2166 0.363647181381052 2984 25236256 SGTC_182 3448-4371 550.524 µM -0.349515988179239 0.367619801881984 no 2167 0.363350984965346 3050 3491403 SGTC_2442 5158906 48.48 µM -0.349873553895589 0.367487389886636 no 2168 0.363216797554281 3151 1893835 SGTC_1179 1021-1431 9.29 µM -0.350630132350981 0.367207269382858 no 2169 0.362932923830332 3099 2840958 SGTC_1750 st081859 2.357 µM -0.351640435331222 0.366833318476115 no 2170 0.362553968255649 3061 5291695 SGTC_2716 st080858 38.6235 µM -0.352118654061538 0.366656355875726 no 2171 0.362374639620322 3168 5296050 SGTC_3040 9091894 49.47 µM -0.353103419244971 0.36629203743742 no 2172 0.362005454802438 3006 25236966 SGTC_82 0054-0107 293.755 µM -0.353426103583345 0.366172685063983 no 2173 0.3618845095442 3089 3104697 SGTC_1271 0832-2808 169 µM -0.354496017677055 0.365777044917547 no 2174 0.361483593978079 3174 3663794 SGTC_88 0180-0332 8.668 µM -0.355832536132052 0.365283018517111 no 2175 0.360982990706698 3010 3101745 SGTC_1454 4239-0054 42.6 µM -0.357725038709237 0.3645838623148 no 2176 0.360274546624306 3206 1340767 SGTC_474 dl-dihydrosphingosine 5 µM -0.358100094364401 0.364445357103137 no 2177 0.360134204219146 3181 3058739 A sphingolipid protein kinase C inhibitor. SGTC_541 4513-1321 94 µM -0.35939435026933 0.363967534207938 no 2178 0.35965005031525 3043 747515 SGTC_3309 9129340 25.759 µM -0.360429689196455 0.363585452353859 no 2179 0.359262913865252 3069 17158987 SGTC_2089 5281248 129.67 µM -0.360553475871176 0.363539779145386 no 2180 0.359216636910733 3060 2737878 SGTC_1366 1683-0113 21.9 µM -0.361760978275161 0.36309435232948 no 2181 0.358765327337563 3036 708623 SGTC_2986 9022445 71.43 µM -0.362463068378431 0.362835448462591 no 2182 0.3585030085165 3195 6459286 SGTC_63 0099-0242 26.702 µM -0.365563595369647 0.361692844324208 no 2183 0.357345372092852 3176 3898502 YLR359W ADE13 SGTC_160 3453-0671 289.699 µM -0.366430073142178 0.361373750337681 no 2184 0.357022091370513 3043 5322268 SGTC_3258 9138477 49.47 µM -0.366522957619445 0.361339549894286 no 2185 0.35698744248748 3091 4970355 SGTC_979 1426-2828 121 µM -0.366673342186751 0.361284180032635 no 2186 0.356931346731456 3184 747872 SGTC_148 3253-0744 288.01 µM -0.368052199764558 0.360776636182682 no 2187 0.356417155990151 3088 6893655 SGTC_773 4358-1457 44.6 µM -0.368153044304488 0.360739525912064 no 2188 0.356379560209827 3209 1186886 SGTC_1236 0330-0013 258 µM -0.368912134497083 0.360460226742541 no 2189 0.356096609160394 3065 4617066 SGTC_3073 9114972 49.47 µM -0.369144766814171 0.360374647048332 no 2190 0.356009911262733 3159 41905075 SGTC_2466 5983409 37.09 µM -0.369722773297217 0.360162043001628 no 2191 0.355794530837444 3080 2879657 SGTC_814 3342-0569 96 µM -0.370469384853091 0.359887486149622 no 2192 0.355516391851767 3101 4346283 SGTC_2112 5488546 200 µM -0.3705346673823 0.359863482768603 no 2193 0.355492075475474 3036 600757 SGTC_177 1327-0068 8.361 µM -0.371907065117047 0.359359001314563 no 2194 0.354981022326889 3165 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1634 st006576 41 µM -0.37319105621598 0.358887239231762 no 2195 0.354503126124898 3235 3915356 SGTC_1722 st034304 3.6505 µM -0.373616002904746 0.358731153310055 no 2196 0.354345013106247 3067 4036148 YLR033W RSC58 SGTC_574 1315-0397 40 µM -0.375468482323387 0.358051000397316 no 2197 0.353656041096878 3067 6794277 SGTC_2647 atorvastatin 60.16 µM -0.379578916707495 0.356543431644399 no 2198 0.352129006773278 3131 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_560 2332-1943 155 µM -0.379857089303706 0.356441487930505 no 2199 0.352025750875261 3081 21177716 SGTC_2820 7989630 71.43 µM -0.38082352751566 0.356087390816113 no 2200 0.351667099999169 3151 2984098 SGTC_2862 9027634 71.43 µM -0.382663214621244 0.355413683716901 no 2201 0.350984746309149 3041 5012562 SGTC_1391 3442-0225 151 µM -0.383059062522523 0.355268780234399 no 2202 0.350837986076415 3053 5227075 SGTC_602 3130-1533 38.1 µM -0.383778403552502 0.355005512918684 no 2203 0.350571348047205 3186 720941 SGTC_2046 4110841 106 µM -0.384515211004962 0.354735924920812 no 2204 0.35029831204512 3243 44119630 YMR134W ERG29 SGTC_3257 9139206 32.98 µM -0.384542567188237 0.354725917058573 no 2205 0.35028817625419 3192 4910041 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.384692736149371 0.354670981711722 no 2206 0.350232538769189 3039 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1814 st052110 31.539 µM -0.385292437372373 0.35445162700943 no 2207 0.350010381982793 3210 674163 SGTC_1471 k673-0312 37 µM -0.386421980409214 0.354038601435126 no 2208 0.349592086965546 3123 24099884 SGTC_135 0933-0004 26.348 µM -0.386460730117276 0.354024435367456 no 2209 0.349577740318951 3196 21230617 YGL099W LSG1 SGTC_703 3875-0075 71.8 µM -0.387590700481637 0.353611431202839 no 2210 0.349159475966591 3097 2850814 SGTC_1608 st001473 40.5 µM -0.388577310172153 0.353250966205842 no 2211 0.348794427056215 3082 7292267 SGTC_2939 9044578 71.43 µM -0.389691138748444 0.352844179039233 no 2212 0.348382474895431 3039 2653634 SGTC_3248 9135562 49.47 µM -0.39141617614186 0.352214501133521 no 2213 0.347744818681408 3140 17650701 SGTC_2469 5655019 90.81 µM -0.391990147638698 0.352005078170318 no 2214 0.347532746751389 3215 2788239 SGTC_1032 k061-1018 98.7 µM -0.392056856323482 0.351980741317096 no 2215 0.347508102210656 3280 4005393 SGTC_2663 amphotericin b 100 µM -0.392683655914192 0.351752100124041 no 2216 0.347276571829386 3156 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_511 blebbistatin 171 µM -0.39473202910761 0.351005277807848 no 2217 0.346520331229513 3253 3476986 A myosin inhibitor. SGTC_2133 5320837 200 µM -0.395224375895391 0.350825857294616 no 2218 0.346338652321105 3242 2841355 SGTC_3223 9129970 49.47 µM -0.395397330659268 0.3507628371886 no 2219 0.346274839367123 3049 17248386 SGTC_1862 st057513 3.81 µM -0.398515654471195 0.34962730899227 no 2220 0.345125060637695 3067 5393163 SGTC_2483 5729050 27.16 µM -0.398637282928196 0.349583045527529 no 2221 0.345080243041742 3280 2865180 SGTC_736 0958-0254 92.6 µM -0.399570137000939 0.349243625951919 no 2222 0.344736577702509 3214 6812352 SGTC_6 0844-0013 19.835 µM -0.399820295870601 0.34915262596606 no 2223 0.344644440432875 3210 1584900 SGTC_1208 2323-2347 50.3 µM -0.399831012795809 0.349148727676988 no 2224 0.344640493434138 3253 5412760 SGTC_1747 st037496 66.6 µM -0.400467931571306 0.348917076621176 no 2225 0.344405949296823 3102 723305 SGTC_2331 7980721 200 µM -0.401138884006108 0.348673108217962 no 2226 0.344158937026546 3140 2981221 SGTC_1971 st069429 63.5 µM -0.401989429073751 0.348363927168585 no 2227 0.343845902981223 3225 1246522 YGL099W LSG1 SGTC_2770 toltrazuril 17.5 µM -0.402375096320258 0.348223766714175 no 2228 0.343703997513254 3211 68591 Kills coccidiodes. SGTC_2263 7948595 193.29 µM -0.404586080661331 0.347420644066973 no 2229 0.342890895887897 3081 2971371 SGTC_869 0564-0080 44.1 µM -0.408202105429962 0.346108628001344 no 2230 0.341562651282686 3150 6843321 SGTC_1251 0490-5699 265 µM -0.408450839045265 0.346018446682407 no 2231 0.341471357862547 3293 3883818 SGTC_907 3448-6986 75.5 µM -0.409489501956437 0.345641961560964 no 2232 0.341090234681842 3300 590582 SGTC_1029 k015-0030 64.7 µM -0.411541606024623 0.344898582381547 no 2233 0.340337719831304 3233 2208316 SGTC_3255 9139072 49.47 µM -0.412799100094542 0.344443347858307 no 2234 0.339876905413135 3200 17646060 SGTC_892 0929-0076 29 µM -0.413815454706881 0.344075574526212 no 2235 0.339504632369438 3153 5751038 SGTC_1503 4585-0012 61.3 µM -0.414005612055676 0.344006781439786 no 2236 0.339434998409276 3284 2922052 SGTC_2816 7982706 58.44 µM -0.414728627372306 0.343745263864609 no 2237 0.339170286579216 3217 2981853 SGTC_3277 9138724 49.47 µM -0.415477952248591 0.343474308896641 no 2238 0.338896025989161 3147 15943418 SGTC_978 1416-0512 87.4 µM -0.415532863440329 0.343454456236982 no 2239 0.338875931285534 3229 6814003 SGTC_1574 spiramycin 23.7 µM -0.416965776829122 0.342936551792803 no 2240 0.338351720097705 3093 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2071 5230951 39.92 µM -0.417783720412966 0.342641050878913 no 2241 0.338052627274953 3241 1799272 SGTC_115 0527-0192 112.043 µM -0.418151705713378 0.342508139120866 no 2242 0.337918101481923 3242 4233931 SGTC_2344 7990960 76.95 µM -0.422797642427713 0.340831765974262 no 2243 0.336221453951013 3166 140813 SGTC_375 3970-0961 9.27 µM -0.423562275698228 0.340556166552844 no 2244 0.335942536143454 3178 2898222 SGTC_795 0685-0265 78 µM -0.424280858966521 0.340297242664531 no 2245 0.335680498468181 3212 302754 SGTC_1349 flufenamic acid 69 µM -0.424597885571816 0.340183033812455 no 2246 0.335564917330771 3128 3371 A non-steroidal anti-inflammatory. SGTC_1808 st050063 61.5 µM -0.424891688343502 0.340077204436322 no 2247 0.335457816996942 3280 4011993 SGTC_2062 5245942 200 µM -0.425470473579704 0.339868759669793 no 2248 0.335246870724855 3209 1376160 SGTC_1903 st060211 78.3 µM -0.426686031389077 0.33943114588964 no 2249 0.334804013055373 3292 688960 SGTC_796 1234-0020 70.7 µM -0.427526658061332 0.339128637872068 no 2250 0.334497886321266 3168 46495034 SGTC_2990 9074105 71.4286 µM -0.428556953689482 0.338758016978147 no 2251 0.334122838855047 3217 6502001 SGTC_1192 1488-0095 21.4 µM -0.429357727442717 0.338470068110316 no 2252 0.333831456104542 3235 915875 SGTC_2143 5623677 140.463 µM -0.429366347537028 0.338466968938684 no 2253 0.333828319999452 3249 5375313 SGTC_2359 9039622 200 µM -0.430642333039432 0.338008336252987 no 2254 0.333364227610162 3129 6463596 SGTC_1679 SEC14.276 6.7 µM -0.435689183172341 0.336196687085191 no 2255 0.331531127413046 3264 1005053 YMR079W SEC14 SGTC_2480 5767542 37.17 µM -0.436878542095795 0.335770298687286 no 2256 0.331099717231075 3180 2867358 SGTC_1655 st012546 55.1 µM -0.43750109507378 0.335547195980546 no 2257 0.33087399104134 3239 720985 YLR208W SEC13 SGTC_2234 tolnaftate 200 µM -0.437748957304017 0.335458386361266 no 2258 0.330784137888602 3210 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1121 fusaric acid 630.51 nM -0.43810327062284 0.335331451030577 no 2259 0.330655711816419 3156 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_521 r062-0005 13.8 µM -0.439776941833092 0.334732100432384 no 2260 0.330049334767058 3191 2832033 SGTC_712 r015-0009 80.6 µM -0.440291126754877 0.334548052492488 no 2261 0.329863133261036 3273 6813872 YLR060W FRS1 SGTC_850 0388-0143 75.9 µM -0.442508524744187 0.333754810340929 no 2262 0.329060631451949 3183 67273 SGTC_680 0417-1641 114 µM -0.444386439794324 0.333083593747029 no 2263 0.328381607814901 3136 2835990 SGTC_1994 st072947 40.9 µM -0.444436280676326 0.333065786565438 no 2264 0.328363593867578 3290 5286565 YDL195W SEC31 SGTC_1205 4161-2785 76 µM -0.4464378334714 0.33235098196892 no 2265 0.327640504513165 3270 3498106 SGTC_2581 avocatin a 64 µM -0.446516984240198 0.332322727756693 no 2266 0.327611923434101 3186 6710728 A skin care supplement. SGTC_363 0455-0021 3.06 µM -0.448143068472858 0.331742480431445 no 2267 0.327024973576451 3177 4597466 SGTC_2025 5147754 141 µM -0.448474533929184 0.331624250685208 no 2268 0.326905380533254 3229 315777 YLR208W SEC13 SGTC_2726 cimetidine 79.27 µM -0.448938061685689 0.331458944031205 no 2269 0.32673816910375 3218 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_265 mycophenolic acid 32.932 µM -0.449864611805917 0.331128609376128 no 2270 0.326404032869067 3426 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_3106 9121286 49.47 µM -0.452321085042964 0.330253461356426 no 2271 0.325518844167509 3368 15943471 SGTC_2636 apigenin dimethyl ether 100 µM -0.454235749832394 0.329571982143931 no 2272 0.324829577297717 3336 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3351 9150312 21.596 µM -0.454619628789133 0.329435417586546 no 2273 0.324691455417467 3282 4904905 SGTC_1748 st037455 53.6035 µM -0.454819407319677 0.329364355571113 no 2274 0.324619583475539 3341 580690 SGTC_1261 0712-0010 12.7 µM -0.455182583281255 0.329235188228193 no 2275 0.324488944713952 3363 2840123 SGTC_326 k292-0812 17.5 µM -0.455482546560032 0.329128518506642 no 2276 0.324381060597572 3277 3579357 SGTC_2124 5246320 200 µM -0.456055651033016 0.32892475592867 no 2277 0.324174980122815 3289 579342 SGTC_2821 7996764 71.43 µM -0.457430273782759 0.328436227393857 no 2278 0.323680904323035 3428 2987135 SGTC_2995 9067767 71.4286 µM -0.458807897283052 0.327946926520526 no 2279 0.323186061566547 3226 11673567 SGTC_3185 9108267 49.47 µM -0.461631484624089 0.326944974996366 no 2280 0.322172806176324 3297 4910486 SGTC_699 0375-0592 111 µM -0.462412340458098 0.326668107551282 no 2281 0.321892825702543 3356 762578 SGTC_2364 9055074 200 µM -0.464434656442514 0.325951500464372 no 2282 0.321168182554487 3287 6470630 SGTC_332 4112-0506 40.9 µM -0.466452777341145 0.325237020218783 no 2283 0.320445720776386 3223 2790355 SGTC_74 000s-0487 160.283 µM -0.468573253954288 0.324486994317613 no 2284 0.319687349352761 3309 677548 SGTC_1572 epiandrosterone 68.9 µM -0.468634385198183 0.324465382347827 no 2285 0.31966549741092 3251 441302 A steroid. SGTC_1008 4106-0037 6 µM -0.468793514703847 0.324409127438525 no 2286 0.319608617998558 3184 2905394 SGTC_1609 st001574 46.4 µM -0.469605085702452 0.324122286034692 no 2287 0.319318595260372 3214 3960012 SGTC_2202 7226349 200 µM -0.470274296340219 0.323885838938699 no 2288 0.319079529500286 3206 844334 SGTC_1092 toremifene 6.32 µM -0.475158296320323 0.322162368856486 no 2289 0.317337074743516 3279 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1275 0867-0008 21.1 µM -0.47764893241491 0.321284938060075 no 2290 0.316450048577256 3190 3422836 SGTC_2048 5246248 200 µM -0.478201048152657 0.321090566956076 no 2291 0.316253558289687 3350 677046 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.478682650448453 0.32092105996705 no 2292 0.316082205107612 3412 94937 An inhibitor of serotonin biosynthesis. SGTC_1089 terbinafine 2.25 µM -0.480201347436772 0.320386776821177 no 2293 0.315542114412548 3340 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_636 0kpi-0074 126 µM -0.480491471785797 0.320284752310516 no 2294 0.315438982925405 3284 616434 SGTC_1813 st051246 8.6015 µM -0.481911720208091 0.319785506899364 no 2295 0.314934329960526 3308 5291959 SGTC_1259 0671-0132 43 µM -0.482386406817213 0.31961871787799 no 2296 0.314765737822107 3208 X1259 SGTC_2524 avocatin b 10.57 µM -0.482533756530538 0.31956695152704 no 2297 0.314713412189169 3287 6710748 SGTC_682 0kpi-0099 17 µM -0.483474205005557 0.319236639539015 no 2298 0.314379535450689 3332 1714895 YML126C ERG13 SGTC_2024 5144227 134 µM -0.484608230953191 0.318838528459415 no 2299 0.313977136970887 3350 3475211 SGTC_2517 totarol 10 µM -0.484694990182136 0.318808079368646 no 2300 0.313946360370503 3310 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1848 st056003 16.4 µM -0.484940872179237 0.318721791065083 no 2301 0.313859144267098 3364 146492 SGTC_3001 9076041 71.4286 µM -0.485526537003277 0.318516301072479 no 2302 0.31365144665475 3273 16004211 SGTC_2823 7987624 58.44 µM -0.486282150511873 0.318251264288885 no 2303 0.313383566433111 3451 2239440 SGTC_20 0481-0013 4.944 µM -0.487633033505819 0.317777664381987 no 2304 0.312904896498647 3331 182045 SGTC_1468 k284-1086 134 µM -0.48818462159863 0.317584371253485 no 2305 0.312709538160406 3299 15996457 SGTC_2561 acetosyringone 100 µM -0.488577856289543 0.317446600293243 no 2306 0.31257029664363 3212 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2528 xanthyletin 44.79 µM -0.490256501086509 0.316858766558315 no 2307 0.311976201863879 3232 65188 An natural product with antifungal activity of unknown mechanism. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.490405813444044 0.316806502187768 no 2308 0.311923381879289 3344 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_801 0866-0028 10.1 µM -0.490828916622595 0.316658421639256 no 2309 0.311773728048555 3238 6849771 SGTC_1485 3909-9022 254 µM -0.49339064366209 0.315762478948096 no 2310 0.310868296049759 3350 714516 SGTC_3030 9087619 49.47 µM -0.494620089751111 0.315332874141318 no 2311 0.310434159211114 3295 25236973 SGTC_172 1112-0046 2.638 µM -0.495319726266432 0.315088511834326 no 2312 0.310187224300324 3239 2802135 YIL048W NEO1 SGTC_284 0988-0104 32.6 µM -0.496781439970759 0.314578239708183 no 2313 0.309671592417436 3330 4666532 SGTC_1690 st023502 41.2 µM -0.497863990039102 0.314200558533695 no 2314 0.309289954919442 3360 24207482 SGTC_1732 st034308 51.822 µM -0.498332907004104 0.314037022640211 no 2315 0.309124708777186 3192 830119 SGTC_3196 9111891 49.47 µM -0.499619563320593 0.313588485839007 no 2316 0.308671490026197 3351 18891510 SGTC_2925 9010536 32.5 µM -0.502008444428468 0.312756437115705 no 2317 0.307830790482799 3298 2994177 SGTC_561 1550-0330 72.9 µM -0.502514888304424 0.312580164722354 no 2318 0.307652691126145 3277 6812934 SGTC_1957 st077035 62.4 µM -0.503991365409457 0.312066508211129 no 2319 0.307133722340059 3409 705593 SGTC_816 0325-0417 81.3 µM -0.504168806244757 0.312004802292837 no 2320 0.307071379406512 3361 68101 SGTC_2725 haloperidol 53.21 µM -0.50681969917115 0.311083570185725 no 2321 0.306140666513026 3300 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_733 4069-0007 56.1 µM -0.509357956619207 0.310202588663524 no 2322 0.305250670289367 3400 5717425 YNL287W SEC21 SGTC_2186 6124449 200 µM -0.509469587547787 0.310163868608377 no 2323 0.305211555195685 3377 3834182 YLR033W RSC58 SGTC_2754 granisetron 64.02 µM -0.510677992233376 0.309744858826306 no 2324 0.304788276797949 3421 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2335 9018011 154.17 µM -0.510964165276508 0.309645665565723 no 2325 0.304688074707541 3347 6458208 SGTC_854 0422-0053 192 µM -0.511203178125255 0.309562829588645 no 2326 0.304604396756344 3381 3596728 SGTC_1174 0739-0097 51.1 µM -0.511617488527529 0.309419262707929 no 2327 0.304459371682021 3322 728447 SGTC_2842 9000675 19.48 µM -0.511770719065466 0.309366172613402 no 2328 0.304405742701175 3319 2989072 SGTC_1479 0549-0158 134 µM -0.511841468368821 0.309341661301805 no 2329 0.304380982652399 3360 5440202 SGTC_1405 3909-7894 12 µM -0.511848063197887 0.309339376546417 no 2330 0.304378674713669 3385 7104060 SGTC_837 0091-0265 12.5 µM -0.512457708576057 0.309128198891489 no 2331 0.304165355733072 3283 759367 SGTC_1579 chlormadinone acetate 49.4 µM -0.514370584220077 0.308465999312893 no 2332 0.303496460615273 3412 45114258 A steroidal progestin. SGTC_622 1348-1566 26.3 µM -0.514620563226806 0.30837950749522 no 2333 0.303409096417835 3360 7340407 SGTC_2898 9056270 58.44 µM -0.516882190484978 0.307597476606844 no 2334 0.302619200309868 3355 19154699 SGTC_2463 5473429 200 µM -0.51704515168994 0.307541161189813 no 2335 0.302562320075067 3327 5399405 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.517456014240585 0.307399197250839 no 2336 0.302418933241078 3337 4620898 SGTC_905 2-aminofluorene 215 µM -0.51783805623429 0.307267217464388 no 2337 0.302285631835776 3414 1539 An established DNA mutagen. YPR165W RHO1 SGTC_94 0334-0113 514.748 µM -0.517894768613638 0.307247627798253 no 2338 0.302265846101762 3350 6795178 SGTC_1411 3909-8223 150 µM -0.518545843456671 0.307022772065338 no 2339 0.302038741681484 3399 X1411 SGTC_384 k007-0144 5.16 µM -0.519748091912 0.306607753312064 no 2340 0.301619581378638 3346 6824886 SGTC_1512 0259-0544 12.2 µM -0.520333332149905 0.306405816781598 no 2341 0.301415633857522 3364 18476 SGTC_1243 0416-0003 5.65 µM -0.520462389977585 0.306361293421726 no 2342 0.3013706674784 3293 2141977 SGTC_2881 9058953 51.95 µM -0.522268108043663 0.305738643015826 no 2343 0.300741835485807 3285 17122249 SGTC_1661 st013063 9.66 µM -0.522965053192849 0.305498471346936 no 2344 0.300499286396746 3352 721395 SGTC_707 0865-0008 204 µM -0.523158421269866 0.305431850319485 no 2345 0.300432006587353 3335 723043 SGTC_1340 1486-1359 257 µM -0.523487531548875 0.30531847690006 no 2346 0.300317512763218 3304 4309068 SGTC_1220 1838-0075 193 µM -0.525802209235713 0.304521634076222 no 2347 0.299512819702505 3360 5529645 SGTC_171 k064-0041 9.68 µM -0.52608311163532 0.304424994593033 no 2348 0.299415231081358 3310 53325 SGTC_1652 st011932 78 µM -0.527599946756205 0.303903390451152 no 2349 0.298888514985986 3377 1551076 SGTC_261 5-fluorouridine 15.376 µM -0.5276828965684 0.303874877447158 no 2350 0.298859723074854 3493 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_47 0149-0135 24.25 µM -0.52804412261525 0.303750724236194 no 2351 0.298734356072879 3313 5239155 SGTC_593 1203-0218 61.7 µM -0.528805082547857 0.303489256785924 no 2352 0.298470335804438 3439 3666956 SGTC_2167 5876490 200 µM -0.529470018431489 0.303260865741473 no 2353 0.298239718695026 3455 686534 SGTC_420 mitomycin C 81.9 mM -0.530821224013991 0.302796992837406 no 2354 0.297771335516126 3333 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2377 9073351 62.6 µM -0.531084217136882 0.302706743468496 no 2355 0.297680210355583 3308 7337946 YHR072W ERG7 SGTC_1791 st048313 56.1 µM -0.531402651673155 0.302597484818623 no 2356 0.297569892192036 3390 1204976 SGTC_1928 4'-methoxychalcone 40.3 µM -0.532462062554903 0.302234115710579 no 2357 0.297203005273145 3488 641818 SGTC_824 1304-0008 100 µM -0.534554127276327 0.301517130734364 no 2358 0.296479105712076 3340 768245 SGTC_2445 5742597 35.57 µM -0.535485593944572 0.301198148215129 no 2359 0.296157058317806 3296 1774255 SGTC_491 tetrandrine 80.3 µM -0.535562924289346 0.301171673128068 no 2360 0.296130329166269 3403 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1365 1672-3266 55.4 µM -0.537853836263986 0.300387824609699 no 2361 0.295338980527334 3445 6415873 SGTC_2113 5491891 107.031 µM -0.538787864779194 0.300068506192366 no 2362 0.295016618977928 3375 789979 SGTC_2142 5622915 118.518 µM -0.538951352798845 0.30001262997152 no 2363 0.294960210980224 3390 5322196 SGTC_2715 st079500 56.4 µM -0.538965252501641 0.300007879608988 no 2364 0.294955415418261 3366 28246688 SGTC_3150 9097574 49.47 µM -0.540298255638095 0.299552470673786 no 2365 0.294495680585652 3439 17217476 SGTC_2729 fluphenazine 10.66 µM -0.541374951006483 0.299184855958436 no 2366 0.294124584469584 3327 3372 An atypical antipsychotic. SGTC_364 0083-0097 67.7 µM -0.542299598183389 0.298869318369015 no 2367 0.293806066191961 3448 5207356 SGTC_2918 7977171 22.06 µM -0.543295194643694 0.298529738349866 no 2368 0.293463286156288 3391 2236483 SGTC_691 1548-0686 185 µM -0.543892937385014 0.298325943427671 no 2369 0.293257574663863 3364 46495133 SGTC_140 0062-0056 502.533 µM -0.544023831059494 0.298281324880472 no 2370 0.293212536894682 3343 3758964 SGTC_1086 cerivastatin 2.18 µM -0.545773143048266 0.297685317815677 no 2371 0.292610943353271 3414 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.5458783300012 0.297649496956447 no 2372 0.292574787535486 3342 4174840 SGTC_828 2074-0507 139 µM -0.546152731347437 0.297556060292744 no 2373 0.29248047757716 3457 X828 SGTC_1604 st002052 72.4 µM -0.547081334041868 0.297239960277919 no 2374 0.29216142773724 3478 6254834 YHR062C RPP1 SGTC_1753 st043925 64 µM -0.548928121404621 0.296611763143749 no 2375 0.291527389271325 3420 670181 SGTC_635 k038-0028 24.7 µM -0.551715716373527 0.295664697532512 no 2376 0.290571570219674 3402 4035102 SGTC_1140 3229-1848 2.98 µM -0.55268986361557 0.295334065933833 no 2377 0.290237897729548 3459 2849525 SGTC_1223 0764-0573 147 µM -0.55303528485015 0.29521686870342 no 2378 0.290119624483449 3438 1609797 SGTC_1696 st025591 34.7925 µM -0.553035383742178 0.295216835153621 no 2379 0.290119590625762 3432 2787147 SGTC_1810 st050138 53 µM -0.553189658335202 0.295164498577539 no 2380 0.290066773852174 3452 3444541 SGTC_604 1000-0114 314 µM -0.553302997453315 0.295126051797151 no 2381 0.29002797444038 3479 1572745 SGTC_960 1222-0186 7.7 µM -0.554032545243248 0.294878630552729 no 2382 0.289778286393242 3456 3126296 SGTC_3174 9107204 49.47 µM -0.554833075443937 0.294607246160214 no 2383 0.289504420694207 3474 3938802 SGTC_2127 5253358 187.912 µM -0.556150796095388 0.294160782313909 no 2384 0.289053886257507 3356 20612 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.556182836393843 0.294149930466602 no 2385 0.28904293564775 3437 6312947 SGTC_1499 4480-0877 67.3 µM -0.55703894258467 0.293860041223823 no 2386 0.288750411263627 3417 2861909 SGTC_999 SEC7.066 22.7 µM -0.557192551253534 0.293808041217625 no 2387 0.288697939208456 3416 740511 YDR170C SEC7 SGTC_1845 st056753 3.01 µM -0.560598669029213 0.292656088762557 no 2388 0.287535579531266 3328 5375839 SGTC_3266 9136860 49.47 µM -0.560728063291917 0.292612368887248 no 2389 0.287491466562981 3417 4871271 YPR165W RHO1 SGTC_787 4152-0075 138 µM -0.561256720900606 0.292433777007183 no 2390 0.287311270372117 3403 9566539 SGTC_1469 k284-2957 126 µM -0.561373040191185 0.292394488658069 no 2391 0.287271629401945 3430 23884841 SGTC_65 0798-0905 34.986 µM -0.562023829801446 0.29217472131545 no 2392 0.287049891669205 3637 3602145 SGTC_2106 5357045 167.29 µM -0.564128916700488 0.291464374335056 no 2393 0.28633319989393 3432 668842 SGTC_946 3434-1334 87.4 µM -0.564158596492951 0.291454364856392 no 2394 0.286323101273701 3434 4047976 SGTC_1244 0416-0015 52.5 µM -0.564783121017387 0.291243781815579 no 2395 0.286110644536108 3396 96201 SGTC_588 3970-1144 52.9 µM -0.566871121768979 0.290540246335389 no 2396 0.285400872752657 3432 1888707 SGTC_742 0kpi-0133 140 µM -0.567819107863539 0.290221092568409 no 2397 0.285078901895504 3476 2728852 SGTC_1765 st044815 90.4 µM -0.568907353574276 0.289854920909899 no 2398 0.284709507353865 3424 645695 SGTC_927 2425-1185 123 µM -0.569601518862868 0.289621462236678 no 2399 0.284473999032717 3381 730375 SGTC_1908 st060353 56.5 µM -0.570283734013839 0.289392108623299 no 2400 0.284242635725462 3538 4227716 SGTC_958 1222-0007 33 µM -0.571309883273649 0.289047288743965 no 2401 0.28389480169871 3537 7312461 SGTC_926 2268-1401 59.4 µM -0.571345080687338 0.289035464684936 no 2402 0.283882874438836 3488 2931578 SGTC_1420 4'-methoxyflavone 42 µM -0.577344054185303 0.28702352892681 no 2403 0.28185352961964 3478 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2831 7999036 19.48 µM -0.577725286399463 0.286895895741493 no 2404 0.281724802219594 3510 2988270 SGTC_2830 7992007 71.43 µM -0.578247603268492 0.286721072332026 no 2405 0.28154848200791 3413 1952075 SGTC_1933 st074711 15.9 µM -0.578887907138298 0.286506826714845 no 2406 0.281332405188042 3476 17250958 SGTC_2936 9038235 15.59 µM -0.578952468133077 0.2864852288278 no 2407 0.281310622890353 3470 4749415 SGTC_2058 5236698 133 µM -0.579207048116712 0.286400070542934 no 2408 0.28122473783419 3420 766665 SGTC_1780 st038448 24.544 µM -0.580271102059403 0.28604426925909 no 2409 0.280865905908779 3519 728868 YDL195W SEC31 SGTC_2023 5144124 124 µM -0.581065471555131 0.285778782813942 no 2410 0.280598164309773 3414 2830192 SGTC_1080 nisoldipine 24.4 µM -0.581508060043095 0.285630916050712 no 2411 0.280449043806393 3403 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_923 1900-2434 73.3 µM -0.582534374121505 0.285288169438735 no 2412 0.28010339744088 3465 5910570 SGTC_2788 5282734 71.43 µM -0.582634889771018 0.285254611890966 no 2413 0.280069556461637 3524 743706 SGTC_3328 9140624 29.0385 µM -0.583376735750269 0.285007001851422 no 2414 0.279819857707137 3506 4904392 SGTC_866 0495-0101 262 µM -0.584852584730112 0.284514704562429 no 2415 0.279323421434724 3387 635694 SGTC_481 bay k-8644 50 µM -0.586229354510455 0.284055823501724 no 2416 0.278860698900275 3447 2303 A calcium channel antagonist. SGTC_1875 nocodazole 6 µM -0.587144379778872 0.283751039100892 no 2417 0.278553371882687 3530 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_385 1494-0393 12.4 µM -0.587598962192923 0.2835996811687 no 2418 0.278400753900985 3457 3090647 SGTC_1871 st057448 67.3 µM -0.587718393787004 0.283559921597242 no 2419 0.278360663622285 3602 691747 SGTC_2244 6635614 200 µM -0.587920211862155 0.283492741089325 no 2420 0.278292924602784 3326 836499 SGTC_2839 9003951 25.97 µM -0.589106172310759 0.283098116843956 no 2421 0.277895026571244 3497 2990634 SGTC_2185 6113692 200 µM -0.590339156212252 0.282688125414974 no 2422 0.277481646490622 3503 874150 SGTC_1001 4048-4355 44.4 µM -0.591337261097996 0.282356444997873 no 2423 0.277147234107264 3494 21824233 SGTC_1943 st076331 65.2 µM -0.591686222299725 0.282240525822873 no 2424 0.277030362128234 3550 24208415 SGTC_2092 5303694 80.6725 µM -0.592059415532295 0.28211658251475 no 2425 0.276905401204109 3469 1963699 SGTC_1623 st003709 20.3 µM -0.593152915571533 0.281753565011283 no 2426 0.27653941000874 3509 16192618 SGTC_3036 9090181 49.47 µM -0.594160625559549 0.2814192273674 no 2427 0.276202342593452 3520 25236586 SGTC_2518 prenyletin 46.28 µM -0.594641687795935 0.281259688257772 no 2428 0.27604150393448 3455 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1280 0880-0253 10.1 µM -0.598870564567909 0.279859109179076 no 2429 0.274629600893009 3461 6836607 SGTC_1082 camptothecin 424.86 nM -0.599337144663638 0.279704788045583 no 2430 0.274474041369339 3417 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.59967314439995 0.279593681883031 no 2431 0.274362044756335 3542 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_580 1123-0028 41 µM -0.599827437039848 0.279542668596059 no 2432 0.274310622950588 3570 1677248 YPR107C YTH1 SGTC_2362 9071156 126 µM -0.600332720801493 0.279375639865182 no 2433 0.274142258061133 3536 653133 SGTC_79 0052-0007 94.094 µM -0.601825396034293 0.278882498195791 no 2434 0.273645184195751 3571 2801472 SGTC_2824 7998404 51.95 µM -0.604376707355858 0.278040592179887 no 2435 0.272796609083205 3485 837851 SGTC_2795 7780010 54.55 µM -0.60494535130524 0.277853114760891 no 2436 0.272607654163165 3504 953673 SGTC_1724 st037281 8.293 µM -0.608332205472562 0.276737775816795 no 2437 0.271483582645424 3534 574124 YDL195W SEC31 SGTC_1975 st070967 30.8 µM -0.608688009685241 0.276620731905711 no 2438 0.271365628045604 3558 261391 SGTC_2899 9053889 58.44 µM -0.609245936155659 0.276437247541196 no 2439 0.271180718224668 3509 6470052 SGTC_2865 9030313 51.95 µM -0.609538682518041 0.276340996404988 no 2440 0.271083720400409 3462 42562754 SGTC_369 0957-0393 4.5 µM -0.610931347580644 0.275883331795337 no 2441 0.270622515445923 3496 6997992 SGTC_2388 9080168 200 µM -0.613864123200352 0.274920767733884 no 2442 0.269652559829934 3490 15943073 SGTC_1886 st057356 49.9 µM -0.613945663752349 0.27489402903533 no 2443 0.269625616862235 3462 24207747 SGTC_1076 itraconazole 331 nM -0.614638935237518 0.274666743907821 no 2444 0.269396597714257 3557 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3010 9080089 71.4286 µM -0.61512567402203 0.274507224750763 no 2445 0.26923586401739 3553 17027233 SGTC_75 0159-0059 199.013 µM -0.617441894793987 0.273748755430451 no 2446 0.268471647892208 3655 5377270 SGTC_1 0258-0098 57.368 µM -0.617611481321141 0.273693263400942 no 2447 0.2684157372276 3464 6790032 YDR047W HEM12 SGTC_1132 3456-3614 2.5 µM -0.619197795010581 0.27317446016114 no 2448 0.267893032137919 3594 3125502 SGTC_917 harmaline 728.087 nM -0.619243697269441 0.273159455103456 no 2449 0.267877914553021 3507 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_643 k048-0106 28.4 µM -0.619947034232266 0.27292959132222 no 2450 0.267646329236466 3550 6763920 SGTC_1164 k060-0068 93.7 µM -0.620284841821776 0.272819223540044 no 2451 0.26753513639025 3580 5963676 SGTC_2306 7482397 179.52 µM -0.621272827608876 0.272496558026561 no 2452 0.267210064430284 3558 891448 SGTC_3018 9082602 49.47 µM -0.622313741382097 0.272156811920502 no 2453 0.266867793632804 3552 17332089 SGTC_439 amiodarone 34.4 µM -0.622567103445361 0.272074148400579 no 2454 0.266784517251497 3482 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1412 3909-8563 178 µM -0.622916482038184 0.271960178396742 no 2455 0.266669703194868 3619 23767530 SGTC_36 0335-0881 14.2 µM -0.623472116385335 0.271778975092338 no 2456 0.266487160092858 3507 23828853 SGTC_741 4582-0002 126 µM -0.623663532045077 0.271716564593404 no 2457 0.266424288757467 3529 2912688 SGTC_3085 9117376 49.47 µM -0.623961915693595 0.27161929173372 no 2458 0.266326298272975 3560 16480349 SGTC_2625 euphol 100 µM -0.624006638209246 0.271604713719336 no 2459 0.266311612776705 3566 6708538 A triterpene alcohol. SGTC_1694 st024011 44.9 µM -0.624350612318257 0.271492602917698 no 2460 0.266198675976085 3611 2787533 SGTC_638 3970-0837 4.09 µM -0.624671551742259 0.271388020556282 no 2461 0.266093324008846 3524 4118451 YLR208W SEC13 SGTC_2630 antimycin a 100 µM -0.625201116857153 0.271215498649859 no 2462 0.26591953449429 3532 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2734 clemastine 41.6 µM -0.625487870490295 0.271122102776222 no 2463 0.265825453408726 3503 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2713 st079149 53.4 µM -0.62677658519222 0.27070256553839 no 2464 0.265402846992874 3553 3103253 SGTC_827 3253-0474 693 µM -0.62706875565493 0.270607495410196 no 2465 0.265307083373615 3571 5402065 SGTC_771 0250-0039 27.3 µM -0.627456759723659 0.270481267512879 no 2466 0.265179935851298 3502 3005115 SGTC_2771 fluoxetine 41.05 µM -0.627849086667213 0.270353663192356 no 2467 0.265051403208869 3577 3386 A selective serotonin reuptake inhibitor. SGTC_2975 9084847 53.72 µM -0.628398221119797 0.270175107787533 no 2468 0.264871551060942 3528 27211724 SGTC_1622 st003707 19.4 µM -0.629786905791907 0.269723829328824 no 2469 0.264417006937309 3571 10140899 SGTC_671 0560-0003 407 µM -0.629799342459555 0.269719789512698 no 2470 0.264412937963001 3492 3238678 SGTC_1504 k297-0033 30 µM -0.630011947305237 0.26965073353951 no 2471 0.264343383772857 3442 4388117 SGTC_2151 5563267 85.4165 µM -0.631291302750479 0.269235374438849 no 2472 0.263925036300275 3553 5310824 SGTC_2409 alverine citrate 63.97 µM -0.631746532398903 0.26908765576464 no 2473 0.263776258279237 3641 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1916 st067606 49.2 µM -0.632351824794625 0.268891305843857 no 2474 0.26357850305681 3554 19590279 SGTC_1181 1222-0449 220 µM -0.634271772359627 0.268268973224785 no 2475 0.26295173746595 3630 658318 SGTC_300 r073-0011 5.04 µM -0.634649354233586 0.268146668995642 no 2476 0.262828565830866 3623 2735780 SGTC_1376 2910-0861 41.3 µM -0.636388595591856 0.267583666142406 no 2477 0.262261586128913 3578 1112859 SGTC_3059 1327-0034 3 µM -0.636752375608556 0.267465983772884 no 2478 0.262143075837145 3536 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1317 1273-0028 910 nM -0.638231337491379 0.266987810422302 no 2479 0.261661550346829 3553 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1320 1313-0481 95.3 µM -0.638781377705496 0.266810083343373 no 2480 0.261482582230821 3607 6813365 YLR208W SEC13 SGTC_1240 0356-0016 42.1 µM -0.639244766694002 0.266660401119174 no 2481 0.261331856858044 3541 4305613 SGTC_718 1130-0073 349 µM -0.640470932108734 0.26626453452452 no 2482 0.260933240507938 3651 6740020 SGTC_1455 4262-0120 131 µM -0.640645766741248 0.266208113533157 no 2483 0.260876428680327 3652 1529587 SGTC_2468 5987765 72.9 µM -0.642616416445237 0.265572582822675 no 2484 0.260236514093676 3582 26772094 SGTC_1844 rapamycin 4 nM -0.643902822833397 0.265158134798092 no 2485 0.259819225596817 3573 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1873 rapamycin 2 nM -0.644716582028537 0.264896131616065 no 2486 0.25955543424741 3578 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1799 st045822 46.1415 µM -0.64502874402653 0.264795660846539 no 2487 0.259454279310922 3582 3674992 SGTC_2028 5153890 36.43 µM -0.645866446917424 0.264526138120272 no 2488 0.259182925473431 3570 2830968 YPR165W RHO1 SGTC_2489 cantharidin 73.42 µM -0.646799305438387 0.264226164354943 no 2489 0.258880920978005 3589 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2762 leflunomide 42.06 µM -0.647193768886272 0.264099371226401 no 2490 0.25875327180243 3588 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_125 0133-0007 11.75 µM -0.647720010840008 0.263930268558511 no 2491 0.258583029565991 3651 26541 SGTC_2104 5389443 200 µM -0.648079995803615 0.263814622735272 no 2492 0.258466605819828 3632 2244536 SGTC_2247 cerulenin 830 nM -0.648314292079958 0.26373936851422 no 2493 0.258390845994032 3647 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_873 0591-4978 488 µM -0.648584367587672 0.26365263585598 no 2494 0.258303531211702 3662 3305145 SGTC_3287 9117173 37.0625 µM -0.6490284566287 0.263510051739425 no 2495 0.258159991509544 3562 2789709 SGTC_2061 5245884 80.95 µM -0.650172404156816 0.263142944692253 no 2496 0.257790432148606 3586 573863 SGTC_2792 7535235 81.82 µM -0.650848464523893 0.262926111388958 no 2497 0.257572155799665 3548 1281891 SGTC_2426 5582046 32.21 µM -0.65158254542526 0.262690772606049 no 2498 0.257335255380795 3611 2251934 SGTC_1484 3473-2379 286 µM -0.652232172719592 0.262482598701145 no 2499 0.257125704063768 3699 671917 SGTC_2012 4023501 200 µM -0.652581807905265 0.262370592623138 no 2500 0.257012958423814 3553 3477460 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.653499164564511 0.262076832645549 no 2501 0.256717263918013 3659 5393153 SGTC_319 1348-1596 45.5 µM -0.656722537624414 0.26104596847782 no 2502 0.255679670042485 3661 5380505 SGTC_401 neomycin 50 µM -0.658517296225745 0.26047289309646 no 2503 0.255102893324533 3569 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_903 1134-0042 114 µM -0.660365032644034 0.25988357920349 no 2504 0.254509803019198 3598 701009 SGTC_2014 4013930 200 µM -0.660583381971715 0.25981398471159 no 2505 0.25443976455517 3588 64556 SGTC_672 1441-0018 53.7 µM -0.662582571639339 0.259177230262687 no 2506 0.253798967649553 3590 251141 SGTC_2512 diallyl trisulfide 49.23 µM -0.663806334130208 0.258787852649959 no 2507 0.253407135565305 3622 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2805 7950783 58.44 µM -0.663827804679814 0.258781023838652 no 2508 0.253400263826837 3605 1178958 YDL195W SEC31 SGTC_804 1595-0054 20.9 µM -0.663871928194396 0.258766990435911 no 2509 0.253386142220414 3609 761523 Stimulates phospholipase C. SGTC_1641 st009299 47.1 µM -0.666004694296597 0.258089138019967 no 2510 0.252704049953163 3582 4046054 SGTC_1861 st057647 17.4 µM -0.666420293009942 0.257957156462747 no 2511 0.25257124758323 3657 688668 SGTC_321 4534-3890 65.3 µM -0.667662606028403 0.257562844352623 no 2512 0.252174492353041 3636 699746 SGTC_2015 5119600 184 µM -0.668083391820237 0.25742935728593 no 2513 0.252040181328703 3621 2828786 SGTC_887 0885-0007 9.62 µM -0.66823058705771 0.257382670611933 no 2514 0.251993206850528 3642 5719458 SGTC_2443 5493264 126.67 µM -0.668379953875824 0.257335299664378 no 2515 0.251945544077856 3621 5340055 SGTC_3129 9127257 49.47 µM -0.670578157095629 0.256638674757504 no 2516 0.251244650654577 3534 837894 SGTC_3123 9126162 49.47 µM -0.6707172361515 0.256594632754495 no 2517 0.251200340236582 3683 25239884 SGTC_924 2046-0044 21.3 µM -0.672709971460423 0.25596402809607 no 2518 0.250565911292107 3647 3623589 SGTC_3199 9111318 49.47 µM -0.673319208166989 0.255771395571015 no 2519 0.250372117626792 3593 8548020 SGTC_68 0986-0284 82.829 µM -0.673505217719686 0.255712596914393 no 2520 0.250312965207371 3599 423278 YIL048W NEO1 SGTC_2490 carminic acid 95.39 µM -0.673992936143322 0.255558459921335 no 2521 0.250157902315191 3587 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2262 9014885 67.46 µM -0.674490759476595 0.255401179470279 no 2522 0.249999679274407 3575 6457424 SGTC_1230 0170-0365 3.77 µM -0.675083642684725 0.255213932174089 no 2523 0.249811312685686 3712 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3246 9135460 32.98 µM -0.675822954343532 0.254980539724613 no 2524 0.249576529508568 3572 41446951 SGTC_3107 9121808 49.47 µM -0.675994542278165 0.254926387298043 no 2525 0.249522055100117 3587 662681 SGTC_2797 7859098 81.82 µM -0.676133592082604 0.254882508182926 no 2526 0.24947791527984 3661 972681 SGTC_2848 9016370 25.97 µM -0.677553499333803 0.254434662918411 no 2527 0.249027419071255 3648 7894410 SGTC_458 nppb 133 µM -0.677657424051977 0.254401900788114 no 2528 0.248994463719805 3674 4549 A chloride channel blocker. SGTC_1041 0206-0046 107 µM -0.683581349733246 0.252538052098977 no 2529 0.247119782445373 3644 50494 SGTC_2907 7721985 69.9 µM -0.684354928597515 0.25229519265741 no 2530 0.24687553474683 3616 3267881 SGTC_1394 3474-0001 65.7 µM -0.684996375358821 0.252093908547835 no 2531 0.246673104114161 3603 5017666 YIL048W NEO1 SGTC_229 benomyl 22.8748 µM -0.685299169732391 0.251998922004209 no 2532 0.246577577807716 3655 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2159 5658611 73.75 µM -0.686414678608129 0.251649150068529 no 2533 0.246225825396918 3667 793844 SGTC_233 rapamycin 362 pM -0.687701852192493 0.251245870904357 no 2534 0.24582027669326 3665 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3173 9105693 49.47 µM -0.690495221778958 0.250371868452932 no 2535 0.244941406876959 3707 17096658 SGTC_2386 9075165 157.42 µM -0.690857361341838 0.250258678673681 no 2536 0.244827591883649 3637 16452277 SGTC_753 1322-0200 289 µM -0.690880903427205 0.250251321335455 no 2537 0.244820193947416 3690 5403907 SGTC_3179 9107801 49.47 µM -0.691705642189887 0.249993647584926 no 2538 0.244561101498825 3669 4818259 SGTC_340 k038-0059 454 µM -0.692465995199101 0.249756214712176 no 2539 0.244322366803185 3662 23733424 SGTC_1927 st060202 13.8 µM -0.692606212043614 0.249712442750886 no 2540 0.244278355413687 3633 688887 SGTC_2293 7624732 200 µM -0.693196352082969 0.249528261425823 no 2541 0.244093168579592 3633 894453 SGTC_2407 paclitaxel 400 µM -0.693329762719979 0.249486634283608 no 2542 0.244051314616038 3772 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1853 st056710 91.2 µM -0.693537956401184 0.249421680510248 no 2543 0.243986007238232 3738 269167 SGTC_936 3005-4620 401 µM -0.693716507946379 0.249365981865522 no 2544 0.243930005685056 3675 777207 SGTC_383 2324-0395 7.37 µM -0.694208417076179 0.24921256642257 no 2545 0.243775757404471 3671 3146421 SGTC_2492 derrusnin 100 µM -0.694420839732503 0.249146332073476 no 2546 0.243709164168121 3605 1715307 Part of coumarin class of compounds. SGTC_1127 asiatic acid 681.4 nM -0.695241883981524 0.248890414806863 no 2547 0.243451864058315 3650 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3286 9117135 37.221 µM -0.696120381340841 0.248616744586792 no 2548 0.243176721809388 3640 3438150 SGTC_855 0428-0020 25 µM -0.698170709817843 0.247978648697477 no 2549 0.242535220828643 3683 6812414 SGTC_1511 0906-3109 28.5 µM -0.698542569810818 0.247863013455902 no 2550 0.242418972590788 3727 2882180 SGTC_2838 9002687 71.43 µM -0.699757675882638 0.247485359431283 no 2551 0.242039325299041 3674 6457060 SGTC_706 4262-0057 46.9 µM -0.699984065780274 0.247415031621049 no 2552 0.241968627773606 3665 883298 SGTC_2404 5161160 200 µM -0.700008724706249 0.247407371993836 no 2553 0.241960927907549 3643 2831543 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.701534465648673 0.246933688526769 no 2554 0.241484766714358 3658 75037 A free radical scavenger. SGTC_40 0327-0103 19.753 µM -0.701707079433157 0.246880129209245 no 2555 0.241430928568263 3615 409036 SGTC_2448 5185112 27.17 µM -0.701832860762724 0.246841105175638 no 2556 0.241391701546475 3666 5718189 SGTC_693 4161-2696 114 µM -0.70229131141986 0.246698897442924 no 2557 0.241248755316717 3692 805759 SGTC_567 1080-0542 68.4 µM -0.702578395192452 0.246609868692542 no 2558 0.241159265202168 3618 5950415 SGTC_1380 2291-0730 164 µM -0.706872670065025 0.245280209538402 no 2559 0.239822804633889 3690 2999191 SGTC_918 glabranin 770.725 nM -0.706987046932169 0.245244847190311 no 2560 0.239787263689237 3710 124049 Also referred to as licorice root. SGTC_359 0081-0058 15.9 µM -0.708003861147198 0.244930595252809 no 2561 0.239471429854301 3750 3494159 SGTC_2993 9054257 71.4286 µM -0.708345584014674 0.244825032617315 no 2562 0.239365337940994 3692 6470217 YGL055W OLE1 SGTC_1947 st076332 61.6 µM -0.709828408301187 0.244367252736698 no 2563 0.238905275101777 3664 24208416 SGTC_3331 9141060 1.957 µM -0.710349192541908 0.244206584919674 no 2564 0.238743810773676 3689 4906567 YPR165W RHO1 SGTC_1838 st055369 84.5 µM -0.712084891881138 0.24367151356077 no 2565 0.238206104606805 3671 676036 SGTC_2264 7948757 110.76 µM -0.714768338835638 0.242845523424524 no 2566 0.23737610105849 3683 2971411 SGTC_1974 st069448 26.9 µM -0.714771762929806 0.242844470425014 no 2567 0.237375042984448 3663 6323587 YNR016C ACC1 SGTC_968 1309-0633 340 µM -0.715303530541402 0.242680967813197 no 2568 0.237210753730718 3681 3761976 SGTC_519 k048-0011 62.8 µM -0.71681044860179 0.242217959559676 no 2569 0.236745531857258 3728 6836379 SGTC_1760 st045453 10.4495 µM -0.717250291811039 0.242082905827004 no 2570 0.2366098363433 3721 3323419 YIL048W NEO1 SGTC_2060 5238662 140 µM -0.71945393443369 0.241406893153064 no 2571 0.235930637795188 3691 790130 SGTC_2889 9059656 51.95 µM -0.721020402495967 0.240926971163485 no 2572 0.235448481005769 3785 3949838 SGTC_2408 sulbentine 18.36 µM -0.721896933653397 0.240658653149053 no 2573 0.235178923324574 3713 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2565 isoliquiritigenin 100 µM -0.722920847855742 0.240345425287737 no 2574 0.23486425719881 3717 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2479 5617353 43.85 µM -0.724262860535627 0.239935223750849 no 2575 0.234452186632843 3739 2731746 SGTC_2557 derrustone 83.84 µM -0.724667929617825 0.239811484806763 no 2576 0.234327887125495 3705 629853 An antioxidant. SGTC_1751 st044839 27.194 µM -0.725420567867855 0.239581664238557 no 2577 0.234097029408962 3702 5291326 SGTC_3236 9132701 49.47 µM -0.725596975768365 0.239527814902954 no 2578 0.234042937808884 3726 24282524 SGTC_2673 kobusone 100 µM -0.727750594140746 0.238870945896016 no 2579 0.233383136560311 3759 6710676 An epoxy ketone and protein crosslinker. SGTC_1887 st057648 70.8 µM -0.730920486486543 0.237905900945495 no 2580 0.23241386093778 3751 688672 SGTC_3084 9116877 49.47 µM -0.732892176737614 0.237306717812771 no 2581 0.231812097503485 3643 27241325 SGTC_4 0960-0234 25.671 µM -0.734077006994876 0.236947055054754 no 2582 0.231450903067559 3703 6821112 SGTC_1554 st069299 38.7 µM -0.734619099836827 0.236782599289058 no 2583 0.231285751241085 3698 24207999 SGTC_2799 7812892 81.82 µM -0.738664812863697 0.235557227911122 no 2584 0.230055278697271 3723 20205235 SGTC_2123 5259487 200 µM -0.739453002967196 0.235318907602871 no 2585 0.229815983786097 3712 2173474 SGTC_2502 avocadyne acetate 18.59 µM -0.740124723009609 0.235115908747474 no 2586 0.229612159286486 3714 3952079 SGTC_1231 0242-0792 125 µM -0.741339257797857 0.234749112857289 no 2587 0.229243882095732 3740 3707635 SGTC_2093 5331342 194.4 µM -0.741499309524684 0.234700799997389 no 2588 0.229195375138057 3753 33839 SGTC_2343 7990716 14.84 µM -0.741814853201803 0.234605566787677 no 2589 0.229099760018497 3726 6456862 SGTC_35 0133-0054 64.071 µM -0.742049779104448 0.234534678447025 no 2590 0.229028587992963 3724 99677 SGTC_3069 9117009 49.47 µM -0.748161768146369 0.23269456995066 no 2591 0.22718129424997 3677 41904981 SGTC_3155 9099265 49.47 µM -0.749593279512474 0.232264754078158 no 2592 0.226749849819092 3727 25236499 SGTC_1715 st032160 10.2275 µM -0.750339645634218 0.232040830581793 no 2593 0.226525085390707 3664 5289825 SGTC_1476 4112-3294 3.34 µM -0.750486082463167 0.231996910961119 no 2594 0.226481001436464 3788 704369 SGTC_2618 avocadyne 43.43 µM -0.750522836440098 0.231985888363038 no 2595 0.226469937626363 3691 3015189 SGTC_1048 3161-0300 24.5 µM -0.750867569807795 0.231882516267646 no 2596 0.226366179644308 3753 2165101 SGTC_407 eburnamonine 100 µM -0.751074599484476 0.231820448471888 no 2597 0.226303880678241 3649 3195 SGTC_1038 k292-0204 154 µM -0.752037172896504 0.231531989152075 no 2598 0.226014352200625 3711 4454212 SGTC_1708 st033234 31.827 µM -0.752660629795795 0.23134526144193 no 2599 0.225826936966077 3849 674664 SGTC_3307 9126885 69.2785 µM -0.754066921468691 0.230924380294315 no 2600 0.225404519347775 3757 24824909 SGTC_1428 4049-0204 61.7 µM -0.754345839306262 0.23084095537202 no 2601 0.225320792048315 3799 X1428 SGTC_1681 tripelennamine 100 µM -0.754860162216314 0.230687164430575 no 2602 0.225166445572919 3735 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1250 0485-0349 40.2 µM -0.756836746456851 0.230096666495261 no 2603 0.224573837382062 3778 6842794 YDL195W SEC31 SGTC_1449 4112-4002 201 µM -0.757252282264349 0.229972634233583 no 2604 0.224449366469416 3777 2059539 SGTC_3332 9141069 11.198 µM -0.757270963323403 0.229967059049273 no 2605 0.224443771605551 3710 17332883 SGTC_2813 7971799 71.43 µM -0.759894529787087 0.229184832321039 no 2606 0.223658815837211 3835 2234054 SGTC_2394 5221648 200 µM -0.760019469299038 0.229147618369452 no 2607 0.223621473644407 3841 788586 SGTC_1011 4112-3381 17.4 µM -0.760812909228436 0.228911366844485 no 2608 0.223384411362601 3853 2877139 SGTC_294 k038-0071 157 µM -0.760885083134473 0.228889883413237 no 2609 0.223362854495224 3784 24152826 SGTC_502 l-744,832 89.3 µM -0.761148778675386 0.228811400884092 no 2610 0.22328410410251 3725 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1262 0737-0114 49.6 µM -0.761308460199094 0.228763882927707 no 2611 0.223236424279267 3799 765919 SGTC_2566 crystal violet carbinol 226 nM -0.761811322950895 0.228614277454703 no 2612 0.22308631073016 3766 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1113 artemisinin 1.17947 µM -0.763331645122716 0.228162304454706 no 2613 0.222632817047675 3777 2240 An anti-malaria and mitochondrial poison. SGTC_1770 st043884 66.3 µM -0.763528947487979 0.228103685752329 no 2614 0.222574002692627 3769 670149 SGTC_2421 5690543 90.72 µM -0.764365233414263 0.227855318529698 no 2615 0.222324810502199 3813 3397993 SGTC_1949 st076024 69.1 µM -0.764521247020005 0.227809001145594 no 2616 0.222278339990596 3741 2921930 SGTC_1789 tunicamycin 25 nM -0.766559934273656 0.227204242037461 no 2617 0.221671602289823 3739 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1829 berberine 14.4 µM -0.767057017449386 0.227056923899128 no 2618 0.221523808023997 3806 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_220 paclitaxel 373.376 µM -0.767805730396979 0.226835133146023 no 2619 0.221301304784091 3712 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_505 gw-5074 63.9 µM -0.769129882537804 0.2264431797874 no 2620 0.220908105057875 3825 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2341 7987486 176.74 µM -0.769341497812666 0.226380576437345 no 2621 0.220845304147026 3790 1258686 SGTC_813 k007-0158 173 µM -0.771005117588941 0.225888758959889 no 2622 0.220351949118745 3809 6523916 SGTC_1408 3909-7976 48.8 µM -0.772922534064273 0.225322661562264 no 2623 0.219784113880091 3850 24152374 SGTC_2783 7738165 71.43 µM -0.773922654343774 0.225027705478118 no 2624 0.219488265898502 3800 17201110 SGTC_1955 wogonin 32.4 µM -0.775352717025938 0.224606330877234 no 2625 0.21906563330994 3862 5281703 A flavanone. SGTC_1948 st076329 66.6 µM -0.775921674297272 0.224438809527443 no 2626 0.218897617132548 3684 24208413 SGTC_209 4077-0173 175.592 µM -0.776498953058248 0.224268910528882 no 2627 0.218727219366057 3749 15993494 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.777967380478757 0.223837066706209 no 2628 0.218294121786896 3827 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_500 h-89 112 µM -0.779690130576735 0.223331033185149 no 2629 0.217786644735974 3809 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3284 9108171 64.8615 µM -0.780053730487347 0.223224314106997 no 2630 0.21767962476442 3779 8687505 SGTC_2706 st078239 82.5 µM -0.781655330959839 0.222754579029557 no 2631 0.217208579953437 3791 15434492 SGTC_264 promethazine 12.5 mM -0.784686301065426 0.221867166194427 no 2632 0.216318758285638 3785 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.785643683207092 0.221587282318276 no 2633 0.216038132504083 3917 16725076 SGTC_3114 9122766 49.47 µM -0.785878452492727 0.221518680004561 no 2634 0.215969349649538 3819 17176985 SGTC_1284 0929-0043 16 µM -0.786412861467485 0.221362564771603 no 2635 0.215812825488543 3801 1239883 SGTC_624 k048-0052 28 µM -0.78713024443064 0.221153096863574 no 2636 0.215602813096829 3790 6835531 SGTC_826 1683-5028 118 µM -0.788044284581009 0.220886371595554 no 2637 0.215335401481259 3880 722377 SGTC_1746 st038117 42 µM -0.788786875040044 0.22066981257073 no 2638 0.21511829094914 3881 2898218 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.78917194833376 0.220557562911094 no 2639 0.215005757455578 3806 6857784 SGTC_1514 1189-1591 158 µM -0.789941170726597 0.220333430975134 no 2640 0.214781062932998 3840 767698 YMR146C TIF34 SGTC_417 st075190 100 µM -0.790328746809685 0.220220550601419 no 2641 0.214667901318821 3809 222757 SGTC_2044 5102272 200 µM -0.792218351407431 0.219670684117567 no 2642 0.214116684972557 3826 592666 SGTC_412 gemfibrozil 100 µM -0.793860823182394 0.219193373277552 no 2643 0.213638229525197 3773 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1684 st024538 14.6195 µM -0.793968439531871 0.21916212023258 no 2644 0.21360690241608 3804 6732859 SGTC_3072 9116419 49.47 µM -0.795048022559173 0.218848738502926 no 2645 0.213292784028919 3843 17170162 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.795445093025053 0.218733541636142 no 2646 0.213177319118097 3835 551469 SGTC_951 1171-0579 82.7 µM -0.796437053194983 0.21844590972815 no 2647 0.212889024392096 3797 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2008 4012253 172 µM -0.79954617795665 0.217545790717131 no 2648 0.211986890859492 3840 603940 SGTC_376 3970-0862 59.1 µM -0.800025621978106 0.217407178206612 no 2649 0.211847976188846 3850 3135186 SGTC_2346 9031566 143.75 µM -0.801628027005998 0.216944275568212 no 2650 0.211384080114665 3811 4771086 SGTC_3043 9092303 49.47 µM -0.801756889722452 0.216907074481983 no 2651 0.211346800237615 3840 25236084 SGTC_154 3389-1638 511.116 µM -0.802193592792657 0.216781031086718 no 2652 0.211220491044947 3804 5238686 SGTC_1999 st074831 12.5 µM -0.802330235269022 0.216741601361555 no 2653 0.21118097853891 3817 17112523 SGTC_2162 5663267 200 µM -0.803219819047955 0.21648500335626 no 2654 0.210923846101667 3801 6456493 SGTC_1300 1094-0077 113 µM -0.806996881946106 0.215397479421174 no 2655 0.209834139784455 3784 5532636 SGTC_3061 glucosamine 200 µM -0.807215500991685 0.215334629960956 no 2656 0.209771168302209 3739 91431 and experimental redox chemotherapeutic SGTC_3105 9121040 49.47 µM -0.80846987017074 0.214974224729626 no 2657 0.20941007202425 3665 41448907 SGTC_3288 9119690 36.221 µM -0.808648143070379 0.214923031823532 no 2658 0.209358782160086 3843 17595618 YKL019W RAM2 SGTC_427 1354-0053 47.3 µM -0.809034983565815 0.21481197093141 no 2659 0.20924751194881 3972 6813657 SGTC_811 0416-0114 265 µM -0.809216289844159 0.214759929851747 no 2660 0.209195373270199 3902 6612453 SGTC_1531 st059297 52.4 µM -0.810962005693364 0.214259224886444 no 2661 0.208693745079765 3862 7566702 SGTC_1830 st055982 50.3 µM -0.813026370334114 0.21366800254896 no 2662 0.20810146957657 3754 455313 An antimicrobial agent. SGTC_3037 9091026 49.47 µM -0.813430787147997 0.213552291292561 no 2663 0.20798555689443 3848 25236398 YIL048W NEO1 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.81344142214832 0.213549248911772 no 2664 0.207982509238347 3907 5024745 SGTC_1299 1079-1439 3.74 µM -0.81395281179903 0.213402984221555 no 2665 0.207835992190461 3805 323161 SGTC_714 4296-0578 26.1 µM -0.814269343862125 0.213312480830419 no 2666 0.207745333882342 3883 1589775 SGTC_1238 0333-0287 48.8 µM -0.816652098433747 0.212631918176699 no 2667 0.207063636543862 3861 7226 SGTC_3047 9092122 49.47 µM -0.817533269747699 0.212380559438628 no 2668 0.206811872254566 3842 17173831 SGTC_2065 5221596 34.26 µM -0.818961244972243 0.211973590898008 no 2669 0.206404262617455 3853 788581 SGTC_3089 9117425 49.47 µM -0.819052904314026 0.211947483855697 no 2670 0.206378115104725 3826 9401657 SGTC_834 0312-0008 75.7 µM -0.819301374733565 0.211876722267056 no 2671 0.206307244221498 3850 6385573 YIL048W NEO1 SGTC_390 dec-rvkr-cmk 16.7 µM -0.819488684091985 0.211823387800451 no 2672 0.206253827761813 3901 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1264 0783-0040 158 µM -0.820430567268383 0.211555315073577 no 2673 0.205985347926162 3772 2855798 SGTC_2650 prasterone 100 µM -0.822108986150909 0.21107810694026 no 2674 0.205507435793165 3823 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_863 0466-0191 129 µM -0.822566688110441 0.210948082666873 no 2675 0.205377224308509 3906 765160 YPR165W RHO1 SGTC_1388 3346-4487 254 µM -0.824557448168185 0.210383092816692 no 2676 0.204811443942491 3938 3345614 SGTC_2066 5222451 176 µM -0.824629875979769 0.210362554124398 no 2677 0.204790877217533 3853 2281147 SGTC_1061 3448-9325 110 µM -0.827095352634082 0.209664109760527 no 2678 0.204091509060871 3786 723482 SGTC_2651 TUB2.036 5 µM -0.829773312352083 0.208907018343569 no 2679 0.203333481203779 3920 15992207 YFL037W TUB2 SGTC_92 0063-0024 660.874 µM -0.830755575801489 0.208629724863027 no 2680 0.203055861700884 3956 3594437 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.832243874999711 0.208209990910807 no 2681 0.202635651606514 3851 688803 SGTC_2465 5809242 33.21 µM -0.834455901642605 0.207587070980174 no 2682 0.202012063669056 3902 2731748 SGTC_950 1165-0508 94.1 µM -0.835234278343787 0.207368137653515 no 2683 0.201792906553385 3906 6148369 SGTC_2605 digitonin 300 nM -0.838376249611084 0.206485786878498 no 2684 0.200909712014089 3895 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_678 1218-2179 85.9 µM -0.838848140608115 0.206353459459954 no 2685 0.200777266111783 3865 6820081 YOR116C RPO31 SGTC_2279 7948423 32.93 µM -0.840523403317616 0.205884089252815 no 2686 0.200307492637954 3821 1247112 SGTC_1257 0669-0121 16 µM -0.840792813299077 0.205808665913459 no 2687 0.200232006974336 3901 4307855 SGTC_2608 thymoquinone 42.66 µM -0.841873399469699 0.205506312526863 no 2688 0.199929410642813 3875 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2482 5981709 142.65 µM -0.842093561057709 0.205444742576538 no 2689 0.199867792574556 3882 877755 SGTC_1540 guanosine 70.6 µM -0.843561321696764 0.205034551593058 no 2690 0.199457292735719 3776 6802 Guanosine is a purine nucleoside SGTC_2669 eugenol 100 µM -0.844385739299905 0.204804367561236 no 2691 0.199226944323139 3861 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_551 k048-0028 34.9 µM -0.844440453199078 0.204789096440311 no 2692 0.199211662524275 3885 6836383 SGTC_1193 1488-0126 41.5 µM -0.84490609105125 0.204659160310049 no 2693 0.199081636686006 3885 1384710 SGTC_1355 1499-0035 1.68 µM -0.84562025696332 0.204459967811369 no 2694 0.198882310651334 3875 1548538 SGTC_493 zm226600 134 µM -0.845852262632951 0.204395282493334 no 2695 0.198817583007951 3910 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2380 9035439 200 µM -0.848102943379122 0.203768404515334 no 2696 0.198190321281283 4022 6462575 SGTC_3333 9141820 12.094 µM -0.848422770019196 0.203679416886908 no 2697 0.198101283069115 3887 1939433 SGTC_921 1561-0023 372 µM -0.850470940813812 0.203110089387812 no 2698 0.197531654898035 3866 24050882 SGTC_2308 7584454 197.62 µM -0.852094130737503 0.20265956886242 no 2699 0.197080924650621 3919 893577 SGTC_464 bw-b 70c 158 µM -0.85279882648276 0.20246416481754 no 2700 0.196885437411484 3976 5353454 SGTC_893 0958-0369 48.9 µM -0.853370863693704 0.202305628329022 no 2701 0.196726836884806 3893 6819948 SGTC_187 1488-2104 32.728 µM -0.854794533141426 0.201911389842469 no 2702 0.196332452609628 3911 2852859 SGTC_2543 pimpinellin 60.67 µM -0.854832899788546 0.201900771828054 no 2703 0.196321830934471 3766 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2874 9043904 71.43 µM -0.854842552341009 0.201898100525512 no 2704 0.196319158713149 3878 4463428 SGTC_3208 9114115 49.47 µM -0.854944534743495 0.201869878625276 no 2705 0.196290927160096 3942 650895 SGTC_3299 9121982 43.1275 µM -0.855071601347864 0.201834718402511 no 2706 0.196255755049314 3976 17594604 YPL160W CDC60 SGTC_2040 5100729 123 µM -0.855802148285861 0.201632642080914 no 2707 0.196053613372651 3914 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_316 k060-0003 58.6 µM -0.858500764284088 0.200887230276697 no 2708 0.19530800432046 3914 6152314 SGTC_1966 st070145 16.1 µM -0.859544628409683 0.200599338172463 no 2709 0.19502005454604 3866 3748532 SGTC_1437 4092-1038 11.6 µM -0.861435219818238 0.200078554297972 no 2710 0.194499192642063 3938 3977136 SGTC_1516 st013856 110 µM -0.861596489200715 0.200034168553026 no 2711 0.194454801815791 3983 5281404 A mutagen and neurotoxin. SGTC_1285 0929-0069 65.5 µM -0.862028727995675 0.199915233813546 no 2712 0.194335854677276 3944 1206237 SGTC_715 0868-0130 184 µM -0.862404784248648 0.199811792852015 no 2713 0.19423240437365 3944 2876258 SGTC_2658 polymyxin b sulfate 77.05 µM -0.862697498463381 0.199731298887042 no 2714 0.194151904067555 3937 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2033 5192550 145 µM -0.863390698553885 0.199540752469088 no 2715 0.19396134588044 3907 182073 SGTC_1106 tegaserod maleate 11.7 µM -0.867127066638048 0.198515587395389 no 2716 0.192936195932301 3929 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1183 1254-0324 198 µM -0.867546534560224 0.19840069469183 no 2717 0.192821313192033 4014 5799357 SGTC_2098 5376439 882.5 nM -0.868339973353858 0.198183480730277 no 2718 0.19260412263383 3948 2844116 SGTC_1457 k015-0032 57.3 µM -0.869736135744225 0.197801612264771 no 2719 0.192222309817532 3925 4302660 SGTC_1923 st058458 19.1 µM -0.871735039561932 0.197255660768087 no 2720 0.191676470079336 3966 3534982 SGTC_490 phenamil 164 µM -0.872180222218639 0.197134194289699 no 2721 0.19155503363036 3907 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1163 k060-0048 49.9 µM -0.875968748307684 0.196102341208343 no 2722 0.190523511743779 3929 6809982 SGTC_2735 sertaconazole 140 nM -0.878866561249443 0.195315300515307 no 2723 0.189736815592369 4050 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3103 9120822 49.47 µM -0.879726160793655 0.195082204431785 no 2724 0.189503836888638 3939 17141819 SGTC_1139 k015-0024 46.9 µM -0.880812172480533 0.194787954463167 no 2725 0.189209745132398 3932 2766652 SGTC_3209 9113616 49.47 µM -0.885627583643078 0.193486495999186 no 2726 0.187909121311724 3969 16649353 SGTC_1624 st003710 6.25 µM -0.885717349731719 0.193462285440197 no 2727 0.187884928371132 3978 24207033 SGTC_2004 4023728 41.89 µM -0.88573571753619 0.193457331739149 no 2728 0.187879978284412 3953 360084 YDR527W RBA50 SGTC_1734 st037168 69.4 µM -0.886669701297888 0.193205543205442 no 2729 0.187628377689279 4020 708907 SGTC_1215 3852-0577 11.2 µM -0.887488284018641 0.192985029690043 no 2730 0.187408035587474 4027 2884876 SGTC_705 1124-0212 310 µM -0.888610340381942 0.192683014920099 no 2731 0.187106265935434 3895 9554485 SGTC_1717 st033143 58.0435 µM -0.889459176217314 0.192454732700181 no 2732 0.186878176944243 3981 674616 SGTC_2772 vinpocetine 57.06 µM -0.89124929531005 0.191973848220898 no 2733 0.186397721961614 3951 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_647 0140-0236 81 µM -0.891498524036535 0.191906955610956 no 2734 0.186330891512755 3964 990837 SGTC_1287 0971-0001 34.6 µM -0.891577086562597 0.191885872506784 no 2735 0.186309828122896 3941 4665869 SGTC_2301 7769476 200 µM -0.893051442548625 0.191490476148338 no 2736 0.185914812376358 4004 977820 SGTC_2811 7967822 32.47 µM -0.894046107021726 0.191224006817828 no 2737 0.185648611228131 4031 2232244 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.894092398296797 0.191211610983231 no 2738 0.185636228098255 3954 688669 SGTC_296 1222-0039 74.9 µM -0.894442474420049 0.191117883874511 no 2739 0.185542597712236 3960 5984176 SGTC_354 2783-3500 4.88 µM -0.895656340164372 0.190793109590387 no 2740 0.185218167610549 3972 6740761 SGTC_2349 9023730 187.07 µM -0.898875411056923 0.189933476453268 no 2741 0.184359513297834 3988 4126287 SGTC_3124 9127567 49.47 µM -0.89942641428613 0.189786573442528 no 2742 0.18421278743717 3968 17592030 SGTC_2861 9024595 19.48 µM -0.899713205211289 0.189710139749136 no 2743 0.184136447058215 3856 16482810 SGTC_471 1-acyl-paf 4 µM -0.899892589390737 0.189662341044722 no 2744 0.184088707106983 3902 16759367 SGTC_3132 9126706 49.47 µM -0.900187410178085 0.189583799198756 no 2745 0.184010262468265 4056 850858 SGTC_16 erodoxin 22.806 µM -0.901900305155999 0.189127870720098 no 2746 0.183554914626326 3972 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_940 3232-1287 54.8 µM -0.903761922554822 0.188633122607085 no 2747 0.183060828232525 3864 1585493 YIL048W NEO1 SGTC_1785 bathophenanthroline 24 µM -0.903785317822941 0.188626910102821 no 2748 0.183054624247241 3899 72812 An iron chelator. SGTC_272 doxorubicin 8.13 µM -0.903955279371252 0.188581781393771 no 2749 0.183009557577945 3955 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1293 1000-1278 195 µM -0.905676316555542 0.188125181426514 no 2750 0.182553600794221 4024 678847 SGTC_605 1315-0399 119 µM -0.906240446954271 0.187975663348529 no 2751 0.182404299466441 4047 24020461 SGTC_620 0109-0052 432 µM -0.906558873851475 0.187891299345377 no 2752 0.182320059099779 3976 493037 SGTC_1438 4092-1045 4 µM -0.907591383469256 0.187617907156053 no 2753 0.182047074207439 3955 1351342 SGTC_809 3998-0021 90 µM -0.907637016026778 0.187605830051677 no 2754 0.182035015329568 3930 715485 SGTC_69 0096-0274 206.684 µM -0.910236073623535 0.186918756896603 no 2755 0.18134901178678 4141 6741392 SGTC_2645 abamectin 100 µM -0.911997487876438 0.186454005060317 no 2756 0.180885019991772 3937 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2217 6934799 96.0675 µM -0.912514723630424 0.186317667679666 no 2757 0.180748911181947 3919 675606 SGTC_3104 9120930 49.47 µM -0.917978275470329 0.184881312874647 no 2758 0.179315119751192 4019 17014836 SGTC_2712 st079126 47.7 µM -0.918955161137788 0.184625219065861 no 2759 0.17905951290029 3994 3152970 SGTC_1720 st037298 9.481 µM -0.920846813619584 0.184129943597893 no 2760 0.178565205008576 4020 597396 SGTC_1015 4130-4525 82 µM -0.92099151251456 0.184092092383573 no 2761 0.178527429143405 3992 1363237 SGTC_579 4491-1009 110 µM -0.922312364670906 0.1837467998175 no 2762 0.178182833153121 4123 1271041 SGTC_1443 4112-3303 14 µM -0.924492096188111 0.183177864976104 no 2763 0.177615082353719 4023 704433 SGTC_2300 7976697 71.57 µM -0.925953733504741 0.182796977032815 no 2764 0.1772350124211 3906 2236109 SGTC_1189 1431-2119 7.28 µM -0.926639174141895 0.18261852852463 no 2765 0.177056954160905 4012 3107275 SGTC_860 0443-0016 25.1 µM -0.92666317993517 0.182612280797439 no 2766 0.177050720177917 4024 5337942 SGTC_2621 lithochol-11-enic acid 100 µM -0.927452536673413 0.182406917848499 no 2767 0.176845812057576 3918 6708711 SGTC_2834 9001755 58.44 µM -0.927521392847854 0.182389010730461 no 2768 0.176827944880751 3930 2989575 SGTC_2976 9009005 19.48 µM -0.92893510088925 0.182021596783777 no 2769 0.176461360413714 4032 2993148 SGTC_3339 9145883 14.936 µM -0.929619515691133 0.181843887995199 no 2770 0.176284059657969 3929 2030670 SGTC_1322 1348-1070 12 µM -0.930876888494254 0.181517693189623 no 2771 0.175958625440148 3968 6758089 SGTC_1501 4491-0275 38.4 µM -0.931404572588858 0.181380907552336 no 2772 0.175822163229095 3931 5104718 SGTC_2456 5770359 74.46 µM -0.934080857671503 0.180688158240918 no 2773 0.175131092697462 4036 3118787 SGTC_101 0490-5701 117.494 µM -0.93500077271736 0.180450424290786 no 2774 0.174893950602324 3829 4661669 SGTC_152 4469-0003 551.229 µM -0.94056962404349 0.179015456748358 no 2775 0.173462727236062 3935 697280 SGTC_1143 3454-2408 5.08 µM -0.940660146578773 0.178992190592173 no 2776 0.17343952422369 3963 X1143 SGTC_3217 9129673 49.47 µM -0.940663839166576 0.178991241561439 no 2777 0.17343857777026 4055 17248312 SGTC_55 0767-0285 6.563 µM -0.942083354049646 0.178626647108232 no 2778 0.173074983067391 3935 3116166 SGTC_3253 9135987 49.47 µM -0.943254819765945 0.178326115183417 no 2779 0.172775289668172 4019 4182430 SGTC_668 1682-0499 62.6 µM -0.948351011900186 0.177022431076001 no 2780 0.171475394793725 4017 682214 SGTC_782 0083-0095 30.5 µM -0.948825500911013 0.176901356705125 no 2781 0.171354684901235 3999 3591729 An indicator and reagent. SGTC_2251 lansoprazole 556 µM -0.951841099380185 0.176133096440411 no 2782 0.170588787418596 3961 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3149 9097855 49.47 µM -0.953164345459778 0.175796651163247 no 2783 0.170253404174575 4040 25236625 YMR079W SEC14 SGTC_33 0986-0033 35.816 µM -0.953285096789496 0.175765969510993 no 2784 0.170222820202391 3952 2848082 SGTC_308 4092-1169 104 µM -0.953394627499557 0.175738141835236 no 2785 0.170195081240608 3967 2268590 YDL196W YDL196W SGTC_1979 st071809 45.3 µM -0.953733141251216 0.175652155737446 no 2786 0.170109369986021 4127 4976333 SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.95418930790507 0.175536326722842 no 2787 0.169993912928008 4096 5282309 SGTC_1833 st055984 71 µM -0.955853267980258 0.175114227442971 no 2788 0.169573185891417 4065 676288 SGTC_1998 st075797 76.8 µM -0.959638215600371 0.174156494265421 no 2789 0.168618664273408 3997 24208315 SGTC_3032 9089427 49.47 µM -0.960028919110109 0.174057821596431 no 2790 0.168520330237447 4065 17173707 SGTC_944 3370-0224 231 µM -0.960573925372663 0.173920238948575 no 2791 0.168383222182036 4086 4580514 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.96109170032274 0.173789594712217 no 2792 0.168253031220521 4038 676296 Flavone; oxidizing agent. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.962807316569926 0.173357159083051 no 2793 0.16782211415332 4063 688751 SGTC_616 4092-0450 108 µM -0.963835944641888 0.173098213424378 no 2794 0.167564091236459 4057 787165 SGTC_2623 humulene 100 µM -0.964039661437733 0.173046959233547 no 2795 0.167513020881234 4071 6187145 An anti-inflammatory. SGTC_2400 5203494 178.7 µM -0.965375162517276 0.172711192894136 no 2796 0.167178468619018 3966 6777674 SGTC_844 0330-0132 15.3 µM -0.967288952668231 0.172230759948744 no 2797 0.166699802383156 4093 2828079 SGTC_1354 1498-1681 81 µM -0.968431108005165 0.171944442950499 no 2798 0.166414554848204 4055 5754243 SGTC_3101 9120531 49.47 µM -0.969723754616279 0.171620767420462 no 2799 0.166092103276157 4065 24824904 SGTC_1002 4049-0206 172 µM -0.969995931313323 0.171552664689271 no 2800 0.16602426009476 4051 4662749 SGTC_1303 1160-0052 261 µM -0.970618847696363 0.171396866572511 no 2801 0.165869058397454 4009 3562476 SGTC_1458 k015-0034 6.33 µM -0.972185320952189 0.171005474509908 no 2802 0.165479180933799 4084 3598957 SGTC_1191 1487-1166 10.6 µM -0.97322148059008 0.170746898674407 no 2803 0.165221618535812 4099 3955771 SGTC_2587 piperic acid 92.2 µM -0.973616109703046 0.170648483980014 no 2804 0.165123592240678 4062 5370536 SGTC_128 0906-2981 13.371 µM -0.97407096276971 0.170535095374755 no 2805 0.16501065296553 4020 6740226 SGTC_2248 tofa 1.1 µM -0.974293813554148 0.170479559355233 no 2806 0.164955337738521 4013 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2611 pyromycin 23.93 µM -0.97449641778963 0.170429078973782 no 2807 0.164905058459557 4044 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2473 5854593 8.94 µM -0.974547998878458 0.170416228683422 no 2808 0.16489225942415 3955 2872951 SGTC_785 1270-0111 65.3 µM -0.974594029766076 0.170404761627248 no 2809 0.164880838127076 3992 6741994 SGTC_3133 9127736 49.47 µM -0.97874278498996 0.169373267851898 no 2810 0.163853543071775 4042 27243420 SGTC_689 0833-0039 98 µM -0.979659015408355 0.169146009321077 no 2811 0.163627231622347 4029 5374726 SGTC_633 0437-0093 97.7 µM -0.979699875980024 0.169135878973077 no 2812 0.163617143677425 4007 2831118 SGTC_981 1488-1094 54.9 µM -0.980785612478403 0.168866840716781 no 2813 0.163349237353421 4038 3449522 SGTC_1905 st060207 84.5 µM -0.98103356306717 0.168805438801861 no 2814 0.163288095346283 4021 1948547 SGTC_913 3487-1245 167 µM -0.981113533700896 0.168785638117628 no 2815 0.163268378600745 3995 4016153 SGTC_120 rhodamine 6G 52.259 µM -0.98204277539493 0.168555667827018 no 2816 0.16303938764699 4085 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1550 gossypolone 36.6 µM -0.983101467096546 0.16829390663569 no 2817 0.162778751161789 4082 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3071 9117417 49.47 µM -0.985916988504047 0.167599042945644 no 2818 0.162086924804788 4016 45595590 YGL055W OLE1 SGTC_245 methotrexate 289.6 µM -0.9901620200415 0.166554878554564 no 2819 0.161047466551645 4053 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3109 9122853 49.47 µM -0.992064878816059 0.166088192040739 no 2820 0.160582938855661 4126 1234709 SGTC_788 1182-0090 188 µM -0.992799690239345 0.165908201860121 no 2821 0.160403790467582 4125 5715185 SGTC_2197 6588183 93.1375 µM -0.993440453368208 0.165751351505328 no 2822 0.160247677861155 4041 884136 SGTC_717 1532-0246 73.2 µM -0.994189637130714 0.165568082827076 no 2823 0.160065276125791 4079 9561992 SGTC_555 4296-0685 37 µM -0.995348481347444 0.165284859426172 no 2824 0.159783402975489 4040 2908540 YHR072W ERG7 SGTC_1425 4048-4433 7.33 µM -0.997628933685549 0.164728429300768 no 2825 0.159229662739129 4137 23734946 SGTC_106 0092-0003 11.579 µM -1.00104043949019 0.163898290637399 no 2826 0.158403629002563 3986 1072148 SGTC_1950 st077106 7.18 µM -1.00117688161782 0.163865146051805 no 2827 0.158370650604498 4055 13831864 SGTC_1902 st060212 70.5 µM -1.00228649819803 0.163595759015663 no 2828 0.158102620825744 4088 688944 SGTC_1459 k035-0031 35.7 µM -1.00334621770984 0.16333875433677 no 2829 0.157846921899308 3879 3877128 YMR208W ERG12 SGTC_2474 5321570 43.32 µM -1.00458788723561 0.163037956775401 no 2830 0.157547666109837 4100 2841384 SGTC_1878 temozolomide 1 mM -1.00462430084731 0.163029140924598 no 2831 0.157538895665968 3995 5394 DNA alkylating agent. SGTC_1648 st011736 69.8 µM -1.00464974747888 0.163022980398385 no 2832 0.157532766877621 4092 2855514 SGTC_2073 5212005 126 µM -1.00582634050422 0.162738297268149 no 2833 0.157249557073735 3875 691789 SGTC_339 3091-4833 71.4 µM -1.00615180156052 0.16265960730742 no 2834 0.157171276672111 3970 3240077 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.00930826835943 0.161897721255955 no 2835 0.156413407980185 4095 3256 An antibiotic and ribosome inhibitor. SGTC_1465 k213-0056 144 µM -1.00943725756045 0.161866636263419 no 2836 0.15638248890024 3974 24048857 YMR208W ERG12 SGTC_2798 7813637 45.45 µM -1.00946442950008 0.161860088617808 no 2837 0.156375976222012 4117 956368 SGTC_277 nystatin 15.5 µM -1.01079162113175 0.161540484183879 no 2838 0.15605808711937 4097 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_542 3381-0244 89.3 µM -1.01266193332087 0.161090788424683 no 2839 0.155610833159431 4124 1112843 SGTC_3176 9106582 49.47 µM -1.01507050183167 0.160512879450888 no 2840 0.155036110845954 4047 17018027 SGTC_64 000l-0018 272.079 µM -1.0155452570315 0.160399127264771 no 2841 0.154922992370539 4027 6811119 SGTC_859 0439-0102 54.6 µM -1.01724483415832 0.159992337511464 no 2842 0.154518486286774 4116 610143 SGTC_34 0469-0683 81.75 µM -1.01792944175019 0.159828669090569 no 2843 0.154355744389853 4073 3690923 SGTC_658 3253-0951 102 µM -1.01796683286391 0.159819733191596 no 2844 0.154346859204374 4112 1184878 SGTC_2761 levamisole 97.89 µM -1.01975439410527 0.159392914957204 no 2845 0.153922478673214 4078 26879 An alkaline phosphatase inhibitor. SGTC_48 0382-0018 55 µM -1.02047083945382 0.159222058098038 no 2846 0.153752606104359 4162 762596 SGTC_566 0958-0068 16.5 µM -1.02102848744154 0.15908915405385 no 2847 0.153620471062164 4024 6815365 SGTC_2779 methotrexate 400 µM -1.02226672012509 0.158794306429983 no 2848 0.153327339963931 4125 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2781 5567276 71.43 µM -1.02320247541908 0.158571722426482 no 2849 0.153106061385414 4162 2853274 SGTC_137 0438-0332 85.389 µM -1.02412758386009 0.158351872166356 no 2850 0.152887508639337 4076 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2019 4016004 108 µM -1.02464203437927 0.158229700544912 no 2851 0.152766061545439 4145 45595336 SGTC_2849 9019321 12.99 µM -1.02582946567651 0.157947945778005 no 2852 0.152485987230764 4143 16489627 SGTC_709 3807-1509 243 µM -1.02619343644765 0.157861648468099 no 2853 0.152400207281848 4171 1886677 YPL242C IQG1 SGTC_2314 7727897 200 µM -1.02668698848857 0.15774467696639 no 2854 0.152283939032185 4134 900724 SGTC_3136 9095672 49.47 µM -1.03156772556185 0.156591011512676 no 2855 0.151137333100185 3830 17217380 SGTC_2376 9072922 81.32 µM -1.03273467207562 0.156316003891234 no 2856 0.150864041537385 4148 17087968 SGTC_1872 amphotericin b 148 nM -1.03388514683742 0.156045189684056 no 2857 0.150594929777238 4143 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2707 st078556 66.6 µM -1.03396408790591 0.15602661881763 no 2858 0.150576476111878 4065 17250899 SGTC_1078 idebenone 36.1 µM -1.03507362356439 0.155765754950271 no 2859 0.150317264770185 4174 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2175 5807670 165.306 µM -1.03535503632115 0.155699637506312 no 2860 0.150251568011487 4104 241186 SGTC_3171 9103192 49.47 µM -1.03594233575027 0.155561712140543 no 2861 0.150114522625179 4181 13018434 SGTC_170 4197-0004 226 µM -1.03614169946798 0.15551491054703 no 2862 0.150068020369556 4155 218692 SGTC_2205 7238770 200 µM -1.03833230765063 0.155001266571958 no 2863 0.149557686236311 4195 279867 SGTC_507 nimesulide 162 µM -1.03857195752384 0.154945142607858 no 2864 0.149501926666707 4193 4495 A COX2 inhibitor. SGTC_158 k038-0087 26.446 µM -1.03898988999412 0.154847298490452 no 2865 0.149404719112299 4046 X158 SGTC_2825 7998094 58.44 µM -1.03920226752307 0.154797593441075 no 2866 0.149355338068372 4139 2987815 SGTC_719 2810-4230 27.3 µM -1.03966985856866 0.154688195119556 no 2867 0.14924665436253 4124 721079 SGTC_1633 st005664 67.9 µM -1.04014967062923 0.15457599067063 no 2868 0.149135184998055 4122 2063822 SGTC_1467 k284-1082 293 µM -1.04177674904511 0.154195897613023 no 2869 0.148757598160095 4098 3334705 SGTC_547 1120-0019 610 nM -1.04239395350846 0.154051877648054 no 2870 0.148614534332061 4092 3676939 SGTC_2429 5902844 64.44 µM -1.04253805328941 0.154018265879142 no 2871 0.148581146224831 4150 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1374 2889-5571 141 µM -1.04283241971517 0.153949618980233 no 2872 0.148512956727609 4170 2853281 SGTC_1931 st074438 57.1 µM -1.04324987959178 0.153852301138469 no 2873 0.148416288722204 4092 2787313 SGTC_113 0099-0221 2.5 µM -1.04399914988868 0.153677734115215 no 2874 0.148242891472981 4072 89219 SGTC_3142 9086498 49.47 µM -1.04482511087379 0.153485451503222 no 2875 0.148051903461452 4040 25236367 SGTC_430 0958-0115 16.4 µM -1.04502716137533 0.153438438684716 no 2876 0.148005208147045 4096 6833180 SGTC_989 1501-0895 10.3 µM -1.04724619585522 0.152922744615316 no 2877 0.147493022079454 4112 2830112 SGTC_3240 9133527 49.47 µM -1.05206459550565 0.151806930413004 no 2878 0.146384957146221 4088 17617455 SGTC_3081 9117243 49.47 µM -1.05712187997615 0.150641629860741 no 2879 0.145227983337043 4128 45595589 SGTC_231 b-estradiol 524 µM -1.05808265817842 0.150420922295574 no 2880 0.145008879934739 4138 450 A steroid. SGTC_677 0929-0063 136 µM -1.05906690535366 0.15019504700057 no 2881 0.144784655330446 4124 1539583 SGTC_3232 9132874 49.47 µM -1.06087497598384 0.149780701501778 no 2882 0.14437336149315 4108 3784940 SGTC_3207 9114163 49.47 µM -1.06276932689198 0.149347402316122 no 2883 0.143943286379921 4190 849233 SGTC_2141 5621638 7.665 µM -1.06522938927001 0.1487859568628 no 2884 0.143386068590062 4179 2856238 SGTC_3160 9100216 49.47 µM -1.06535170791149 0.148758077665375 no 2885 0.143358400799372 4115 17191039 SGTC_1258 0671-0043 57.1 µM -1.06706925598234 0.148366978160602 no 2886 0.142970281757988 4179 4298767 SGTC_197 4544-0043 41.561 µM -1.07111919773471 0.147447498875309 no 2887 0.142057918600864 4145 896523 SGTC_2765 myclobutanil 7.74 µM -1.07788734712717 0.145919429488113 no 2888 0.140542016336128 4209 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_203 k066-0004 30.888 µM -1.07907378932792 0.145652662362799 no 2889 0.140277417284115 4259 6795412 SGTC_2412 st077135 33.4 µM -1.08519878465874 0.144280697833771 no 2890 0.138916811192023 4260 13258915 SGTC_489 paxilline 115 µM -1.08914813086706 0.14340070040086 no 2891 0.13804428397427 4171 105008 A toxic potassium channel blocker. SGTC_465 cgp-37157 41 µM -1.08915849044487 0.143398396844679 no 2892 0.138042000163396 4136 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_509 pifithrin 175 µM -1.09096594444023 0.14299687372102 no 2893 0.137643934022316 4251 4817 A p53 inhibitor. SGTC_3164 9100705 49.47 µM -1.09270678205606 0.142610868183341 no 2894 0.137261280539982 4208 17174235 SGTC_1120 ficusin 1.78878 µM -1.0939893916389 0.142326919282279 no 2895 0.136979815435033 4241 6199 A DNA cross-linker. SGTC_2545 solidagenone 89.61 µM -1.09672882958663 0.141721733941309 no 2896 0.136379974933891 4039 6708572 An anti ulcer agent SGTC_1199 1638-0010 4.46 µM -1.09845299847841 0.141341732647682 no 2897 0.136003365375609 4172 3111136 SGTC_1401 3807-4679 7.6 µM -1.0992367446286 0.141169226036345 no 2898 0.135832407595491 4124 3291456 SGTC_1968 st069590 43.6 µM -1.10215649193037 0.140527831320004 no 2899 0.135196821619499 4175 6384066 SGTC_2790 5423970 71.43 µM -1.10637298014677 0.139605071521693 no 2900 0.134282557765731 4255 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3151 9099821 49.47 µM -1.10652726433078 0.139571385433345 no 2901 0.134249184946171 4177 17174189 SGTC_2968 9090663 33.37 µM -1.10782668079136 0.139287892875969 no 2902 0.133968337500316 4157 25236811 SGTC_2826 7992541 19.48 µM -1.10855738936776 0.139128647049025 no 2903 0.133810584362146 4208 2985066 SGTC_2097 5376186 200 µM -1.10912980194458 0.139003985802369 no 2904 0.133687095072397 4179 742755 SGTC_1828 st055811 49 µM -1.11031913646119 0.138745213164024 no 2905 0.133430764866114 4206 5877589 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.11049258787896 0.138707501441111 no 2906 0.133393410177892 4160 2333 A French combination drug. SGTC_2760 etidronate 98.04 µM -1.11072352572257 0.138657301884924 no 2907 0.1333436863159 4159 3305 A chelator and antioxidant. SGTC_2664 lyso-paf C-16 73.48 µM -1.1109781360462 0.138601970926405 no 2908 0.133288880247946 4175 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1190 1486-1332 13 µM -1.11151180831105 0.138486044090436 no 2909 0.133174055080349 4185 4150046 SGTC_2620 irigenin 100 µM -1.11319978788491 0.138119808201747 no 2910 0.132811316881608 4233 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1283 0922-0125 16.4 µM -1.11716858998052 0.137261312896934 no 2911 0.131961123927902 4207 3360884 SGTC_1768 st044301 37.178 µM -1.11877588697062 0.136914676015894 no 2912 0.131617880571453 4208 3931349 SGTC_1855 st056195 39.6 µM -1.11986627762688 0.136679858361194 no 2913 0.131385375288317 4156 4028379 SGTC_396 dithiazanine 1.25 µM -1.12016651237774 0.136615250625573 no 2914 0.131321405700711 4204 10578 An antihelmenthic. SGTC_1194 1488-0194 225 µM -1.12123117193032 0.136386314104803 no 2915 0.131094737134553 4159 1391452 SGTC_3281 9140613 49.47 µM -1.12305657726879 0.135994403486086 no 2916 0.13070673322732 4222 16013766 SGTC_2214 7179297 48.276 µM -1.12343367944641 0.135913536639524 no 2917 0.130626676310812 4263 769744 SGTC_2350 9023895 38.85 µM -1.12471441628617 0.135639137676166 no 2918 0.130355035376542 4233 2997209 SGTC_2176 5809774 33.9695 µM -1.12551203755359 0.135468438540778 no 2919 0.130186059583248 4152 2870539 SGTC_2955 9076254 12.21 µM -1.1267755534096 0.135198334595951 no 2920 0.129918694510909 4135 16459619 SGTC_628 1636-0253 16 µM -1.12716667829291 0.135114798051284 no 2921 0.129836008004616 4208 4456143 SGTC_2741 miltefosine 3.04 µM -1.12967698907088 0.134579487903186 no 2922 0.129306178396051 4234 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1488 4013-0813 75.9 µM -1.1304727742236 0.134410095335844 no 2923 0.12913853214753 4155 2910057 SGTC_1422 4031-0024 15.5 µM -1.13180085010944 0.134127724339003 no 2924 0.128859085129508 4148 782427 SGTC_3215 9129942 49.47 µM -1.13349587203876 0.133767926858194 no 2925 0.12850303686251 4207 17682944 SGTC_965 1291-5240 308 µM -1.13542571065961 0.133359093879336 no 2926 0.128098496089467 4245 2834598 SGTC_1447 4239-0816 81.9 µM -1.13677416124505 0.133073937614446 no 2927 0.127816353817454 4232 1341554 SGTC_922 1866-0035 480 µM -1.13723758218425 0.132976035159086 no 2928 0.127719489995933 4143 3156169 SGTC_3263 9137018 49.47 µM -1.13773004794805 0.132872051041431 no 2929 0.127616611185469 4197 43844957 SGTC_847 0342-0274 5.54 µM -1.13827875558176 0.132756257417324 no 2930 0.12750205101198 4235 18097 SGTC_2635 hydroquinidine 100 µM -1.14028583058959 0.132333297050611 no 2931 0.127083619524691 4146 442912 An experimental heart treatment. SGTC_747 3448-8087 38.7 µM -1.14067109722444 0.132252214369897 no 2932 0.127003409254979 4297 5168703 SGTC_2316 5844804 197.44 µM -1.14356557984379 0.131644140760703 no 2933 0.126401921557434 4242 776813 SGTC_1158 4092-0494 91.8 µM -1.14653481073461 0.131022371688238 no 2934 0.125786966095743 4336 1148199 SGTC_2201 6605497 169.863 µM -1.14937783515225 0.130428934997563 no 2935 0.125200107783606 4175 670741 SGTC_232 clozapine 119 µM -1.15105638100771 0.130079439033012 no 2936 0.124854520603303 4199 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1026 k007-1105 30.6 µM -1.15201283173808 0.129880583185374 no 2937 0.124657900239621 4225 7066794 SGTC_1075 aripiprazole 15.2 µM -1.15236718049373 0.129806963930326 no 2938 0.12458511070592 4302 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1777 st045864 34.765 µM -1.15351817557565 0.129568033362163 no 2939 0.124348880870174 4233 4691462 SGTC_2908 7930301 100 µM -1.15458233097171 0.129347400710049 no 2940 0.124130752837318 4217 2223178 SGTC_608 k048-0125 159 µM -1.15492937369829 0.129275504247281 no 2941 0.124059674768558 4287 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2755 lomerizine 42.69 µM -1.15498930186146 0.129263091800221 no 2942 0.124047403722661 4209 3949 A calcium channel blocker. SGTC_215 1287-0124 461.5 µM -1.15614689215477 0.129023491345409 no 2943 0.123810539171847 4257 5560863 SGTC_562 3772-2733 112 µM -1.15639316157935 0.128972557739739 no 2944 0.123760188727787 4228 2876874 YIL048W NEO1 SGTC_2887 9044784 58.44 µM -1.15861624274389 0.128513409656193 no 2945 0.12330632254929 4210 6465546 SGTC_3063 1327-0034 4 µM -1.16043429830924 0.128138758523701 no 2946 0.122936014610678 4145 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_626 0214-0009 33 µM -1.16043544396803 0.128138522674425 no 2947 0.122935781504969 4306 3437874 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.16167366234698 0.127883795001583 no 2948 0.122684023963943 4264 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_765 1319-0117 244 µM -1.16728382821768 0.126734075214562 no 2949 0.121547883630498 4237 3487746 YGL099W LSG1 SGTC_758 0868-0029 16 µM -1.16837039658081 0.126512233848959 no 2950 0.121328695343001 4264 762687 SGTC_1663 st014140 55.4 µM -1.16901585680834 0.126380580340351 no 2951 0.121198621377459 4329 4207120 SGTC_3304 9125678 46.087 µM -1.17270611913726 0.125629716471832 no 2952 0.120456838355597 4190 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_250 brefeldin a 552.239 µM -1.17462796364327 0.125239910577522 no 2953 0.120071795343822 4143 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_973 1325-0077 65.9 µM -1.17480404700044 0.125204238035701 no 2954 0.120036560336172 4269 2835149 SGTC_1847 st056231 15 µM -1.18037463989352 0.124079358650966 no 2955 0.118925621864396 4259 5393180 SGTC_720 r052-1644 49.9 µM -1.18105583699724 0.12394229011378 no 2956 0.118790271198708 4285 1422863 YOR257W CDC31 SGTC_895 0964-0006 13.7 µM -1.18321520297277 0.123508489184337 no 2957 0.118361934623184 4254 6738897 SGTC_1439 4092-1168 46 µM -1.1853423309417 0.123082205478291 no 2958 0.117941061498722 4266 2886240 SGTC_1959 st077091 55.8 µM -1.18543998953352 0.123062659154695 no 2959 0.117921764240884 4275 821356 YKL052C ASK1 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.18619785397392 0.122911046885902 no 2960 0.117772086775233 4288 66535 A nucleotide analog. SGTC_598 3937-0236 20.2 µM -1.18828367806012 0.122494450099235 no 2961 0.117360832982654 4330 1379313 SGTC_488 nitrendipine 139 µM -1.18870430665644 0.122410559120577 no 2962 0.117278022659018 4306 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2122 5258151 111.688 µM -1.18919504794116 0.122312735704226 no 2963 0.117181461374715 4278 2173356 SGTC_1350 1495-0454 146 µM -1.1917584144731 0.121802651117545 no 2964 0.116677993008533 4320 1069057 SGTC_2242 6630449 61.2675 µM -1.19358012338645 0.121441058719604 no 2965 0.116321126482367 4325 691249 YDR170C SEC7 SGTC_1569 carminic acid 40.6 µM -1.19474049973251 0.12121112854887 no 2966 0.116094216874809 4360 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_897 1000-0139 31.4 µM -1.19561896173327 0.121037263850737 no 2967 0.115922644216894 4237 6151020 SGTC_3075 9116269 49.47 µM -1.19598305475618 0.120965254222271 no 2968 0.115851585904879 4302 17015205 YNL244C SUI1 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.2015313685943 0.119871647581535 no 2969 0.114772572974671 4238 688761 SGTC_1027 k015-0025 8.67 µM -1.20425888301584 0.119336600946004 no 2970 0.114244766723067 4276 3598955 SGTC_858 0438-0351 2.77 µM -1.20587986588728 0.119019418171354 no 2971 0.113931907484389 4259 2799119 SGTC_1290 0986-0249 10.2 µM -1.20843056868184 0.118521520305627 no 2972 0.113440843743773 4145 53329 SGTC_1607 st000305 50.6 µM -1.21148941447024 0.117926376159105 no 2973 0.112853944600662 4297 5457690 SGTC_1316 1272-0050 65.9 µM -1.21181035178914 0.11786405577917 no 2974 0.112792492403848 4251 7340392 SGTC_2436 5633522 8.09 µM -1.21418396154314 0.117403865966636 no 2975 0.112338741805276 4283 5724242 SGTC_3320 9137005 35.139 µM -1.2147372165505 0.117296785295403 no 2976 0.112233166632074 4336 4908713 SGTC_2486 5283202 22.39 µM -1.21599502486641 0.11705359811499 no 2977 0.111993408616052 4333 1377751 SGTC_318 1488-0629 67.2 µM -1.21834213471509 0.116600758979725 no 2978 0.111546992327038 4354 3662576 SGTC_2411 st077133 39.94 µM -1.22440132408569 0.115437477900083 no 2979 0.110400435036215 4321 1403142 YNL221C POP1 SGTC_1761 st044296 37 µM -1.22777818573714 0.114792757319236 no 2980 0.109765123355629 4296 1826700 SGTC_2450 5739737 12.93 µM -1.23188177528867 0.114012740945168 no 2981 0.10899662509017 4339 2262825 SGTC_615 k087-0205 167 µM -1.23305386664401 0.113790642986932 no 2982 0.108777833869029 4334 9642773 SGTC_971 1315-0384 26.7 µM -1.23448902573442 0.113519116842438 no 2983 0.108510366785285 4344 6769120 SGTC_2075 5212009 200 µM -1.23484050961076 0.113452688038375 no 2984 0.108444933782273 4236 780898 SGTC_2644 guaiazulene 100 µM -1.23808620960493 0.112840575635084 no 2985 0.107842048339617 4332 3515 A coloring agent. SGTC_3131 9127911 49.47 µM -1.2400100644764 0.112478867229588 no 2986 0.107485835789302 4359 45595681 SGTC_613 3914-0030 117 µM -1.24086534169056 0.112318330822389 no 2987 0.107327748984589 4022 1145395 SGTC_341 1486-1430 230 µM -1.24460003221385 0.111619244087687 no 2988 0.106639404268599 4282 2054753 YPL210C SRP72 SGTC_963 1269-2853 151 µM -1.24517213932665 0.111512428460988 no 2989 0.106534240690453 4304 3668223 SGTC_2575 plumbagin 510 nM -1.24542051379151 0.111466078325219 no 2990 0.106488608310828 4225 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_833 3852-0053 558 µM -1.24986722587019 0.110638591920351 no 2991 0.105674026752716 4379 3123681 SGTC_2598 perillyl alcohol 100 µM -1.24999530182469 0.11061482373604 no 2992 0.105650631786798 4354 10819 An apoptosis inducer. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.25190870974034 0.110260171422949 no 2993 0.105301565348126 4302 364106 SGTC_1085 doxorubicin 7.67 µM -1.25660965893174 0.109392310023535 no 2994 0.104447507724285 4351 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2484 5809818 12.04 µM -1.25913865116613 0.108927457404299 no 2995 0.103990127931111 4290 2870548 SGTC_766 1391-0721 126 µM -1.25933190322198 0.108891994344296 no 2996 0.103955237240402 4357 1020919 YIL115C NUP159 SGTC_1020 4335-0961 93.3 µM -1.26037203208801 0.108701266216344 no 2997 0.103767592987735 4292 669075 SGTC_713 1488-1073 324 µM -1.26158034335862 0.108480000329901 no 2998 0.103549916480413 4355 3312542 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.26548340071316 0.107767486969308 no 2999 0.102849047537896 4318 442882 SGTC_2987 9018338 71.43 µM -1.26832050625135 0.107251685972125 no 3000 0.102341758454863 4351 5055682 SGTC_1487 3970-0795 2.82 µM -1.26867793698215 0.107186829612808 no 3001 0.1022779772906 4393 3765103 SGTC_395 anisomycin 6.25 µM -1.27358977397246 0.106298432423421 no 3002 0.101404419113361 4347 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2666 tannic acid 100 µM -1.27826012218954 0.105458656670038 no 3003 0.100578861780253 4335 16134267 A thiamine antagonist. SGTC_688 0527-0193 473 µM -1.2831020007711 0.104593115111973 no 3004 0.0997281714589564 4400 4007154 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.28382193075278 0.10446486005753 no 3005 0.099602134129121 4399 368090 SGTC_1568 digitonin 820 nM -1.28626496534992 0.104030484535055 no 3006 0.0991753025402473 4328 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3204 9114183 49.47 µM -1.29121896668444 0.103153678619045 no 3007 0.0983138800385456 4326 17027248 SGTC_3153 9100258 49.47 µM -1.29193275671561 0.103027788974044 no 3008 0.0981902162843349 4278 25236848 SGTC_1692 fluoroquinolonic acid 71 µM -1.29402135079339 0.102660069123705 no 3009 0.0978290230151862 4365 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_587 k089-0003 57 µM -1.29437934698267 0.102597135863513 no 3010 0.0977672104576157 4281 9659696 SGTC_3285 9112818 20.8695 µM -1.29549586229489 0.102401040308218 no 3011 0.0975746139073776 4337 17017947 YPR165W RHO1 SGTC_1560 lithocholic acid 53.1 µM -1.29554281945996 0.102392799114774 no 3012 0.0975665199960562 4291 9903 A bile acid which acts as a detergent. SGTC_357 1325-0123 420 µM -1.30072846980009 0.101485659457316 no 3013 0.0966757068449142 4382 1098503 SGTC_1818 st052136 56.3 µM -1.30374441902266 0.100960770996238 no 3014 0.0961603694896869 4028 674169 SGTC_2969 9091408 28.7 µM -1.30648986585922 0.10048468338344 no 3015 0.0956930115488782 4306 4286311 SGTC_2966 9084041 48.03 µM -1.30663165300324 0.100460140648611 no 3016 0.0956689205590238 4287 17741380 SGTC_256 clotrimazole 625 nM -1.30678872965787 0.100432956473364 no 3017 0.0956422369458637 4303 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1605 st000082 49.1 µM -1.30936380250543 0.0999880713651404 no 3018 0.0952055733883406 4337 1114022 SGTC_351 caspofungin 25 nM -1.31061966355444 0.099771624048069 no 3019 0.0949931462492521 4367 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2876 9059903 25.97 µM -1.31133636030147 0.0996482550647926 no 3020 0.0948720745879483 4359 6916095 SGTC_681 1642-0006 26.6 µM -1.31188676136165 0.0995535871770442 no 3021 0.0947791724884197 4388 4446530 SGTC_1216 1165-0504 9.65 µM -1.31503934571736 0.0990126151058756 no 3022 0.0942483397402469 4392 6304004 SGTC_2326 6164455 177.58 µM -1.31509292325279 0.099003440014175 no 3023 0.094239337334354 4326 2888790 SGTC_2051 5263410 176 µM -1.31568967350527 0.0989012892543953 no 3024 0.0941391107935358 4337 227584 SGTC_374 0880-0231 82.3 µM -1.3213444391394 0.097937140760273 no 3025 0.0931932713998786 4249 6833587 SGTC_1362 1611-0397 101 µM -1.32404274555961 0.0974795095479899 no 3026 0.092744424374951 4352 27816 SGTC_1119 parthenolide 318.541 nM -1.32508530524981 0.0973031127377727 no 3027 0.092571429705589 4437 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_1736 st036774 51 µM -1.3257777093057 0.0971860903086085 no 3028 0.0924566692658787 4431 1272247 SGTC_825 1988-2224 89.6 µM -1.32637505797012 0.0970852160959275 no 3029 0.092357748106705 4367 1180859 SGTC_991 3996-0057 64.7 µM -1.32774937207081 0.0968534276295847 no 3030 0.092130458611281 4414 715343 SGTC_2896 9052656 71.43 µM -1.32778888739367 0.0968467690862914 no 3031 0.0921239295410222 4122 6469436 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.32898423277892 0.0966455058376064 no 3032 0.0919265859090848 4310 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3244 9134489 49.47 µM -1.33094974617563 0.096315235687211 no 3033 0.091602773535309 4397 16584271 SGTC_311 1315-0136 58 µM -1.33199376845503 0.0961401436826055 no 3034 0.091431118116171 4397 6759207 SGTC_352 k048-0007 5.11 µM -1.33239710748771 0.096072562771161 no 3035 0.0913648660527737 4327 6811911 SGTC_1749 st037932 54.2 µM -1.33557990880635 0.0955404978665699 no 3036 0.0908433103237362 4410 594497 SGTC_3049 9092223 49.47 µM -1.33568858147794 0.0955223695549924 no 3037 0.0908255415541271 4379 8623917 SGTC_701 4424-0219 185 µM -1.33994093920555 0.0948149956246633 no 3038 0.0901322734750645 4412 2911779 SGTC_1416 3966-0321 25.3 µM -1.34013833289231 0.0947822534534616 no 3039 0.0901001878375837 4432 582530 YLR208W SEC13 SGTC_2539 epi(13)torulosol 80 µM -1.3410468602144 0.094631661240397 no 3040 0.0899526193780584 4373 6708597 SGTC_281 1672-3440 14.9 µM -1.34178051704607 0.0945101833139607 no 3041 0.0898335855728439 4425 6833000 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.34184030550702 0.0945002886885212 no 3042 0.0898238902212003 4428 688664 SGTC_1326 1431-2094 10.8 µM -1.34185831206463 0.0944973088627706 no 3043 0.0898209704137092 4393 616278 SGTC_805 3852-0218 479 µM -1.34234347648565 0.0944170472211569 no 3044 0.0897423263684027 4372 6615355 SGTC_2634 4'-methoxyflavone 100 µM -1.34253557098389 0.0943852825707888 no 3045 0.0897112024389252 4401 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_95 0471-0001 561.058 µM -1.35106281773208 0.0929831493577273 no 3046 0.0883376554538441 4395 4015405 SGTC_1809 st050081 57.6 µM -1.35203681795843 0.0928239797364538 no 3047 0.0881817687352748 4463 5036894 SGTC_2957 9076800 11.52 µM -1.35234114190706 0.0927742889165542 no 3048 0.0881331043864128 4373 16459615 SGTC_1756 st041558 35.5 µM -1.35540193679701 0.0922756076707953 no 3049 0.0876447664550095 4485 3955792 SGTC_2739 tacrine 100.86 µM -1.35547248191395 0.0922641375149355 no 3050 0.0876335351056922 4449 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_253 dyclonine 31.25 µM -1.35754937807344 0.0919269210459014 no 3051 0.0873033575711068 4505 3180 An oral anasthetic. SGTC_1669 st015249 58.4 µM -1.35791098992839 0.0918683011398096 no 3052 0.0872459648630575 4523 722793 SGTC_2367 9070478 135.38 µM -1.35945508716131 0.0916183032722004 no 3053 0.0870012126179279 4346 572802 SGTC_2236 dapsone 200 µM -1.36148707447205 0.091290081962156 no 3054 0.0866799077565733 4421 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3237 9133362 49.47 µM -1.3645221558815 0.0908014583627304 no 3055 0.086201642966994 4373 43845137 SGTC_3064 1327-0027 10 µM -1.36465449989159 0.0907801962876794 no 3056 0.0861808333448117 4353 16000455 YPR107C YTH1 SGTC_3346 9158254 43.5805 µM -1.36644643025725 0.0904926725791741 no 3057 0.085899442029861 4434 17639500 SGTC_2288 7946289 167.31 µM -1.36739873990554 0.0903401453915598 no 3058 0.0857501785500004 4434 1246052 SGTC_987 1497-1013 404 µM -1.37314751498317 0.089423442699154 no 3059 0.0848532461162301 4426 1676435 SGTC_2695 st077686 51.995 µM -1.37349297782933 0.0893685762074591 no 3060 0.0847995713857411 4403 2876092 SGTC_2177 5811945 192 µM -1.37572012074136 0.0890154618272879 no 3061 0.084454150060121 4437 5343475 SGTC_2897 9048598 12.99 µM -1.37759205644206 0.0887194698462497 no 3062 0.0841646374330458 4403 6467404 SGTC_776 4476-4378 112 µM -1.37782764335677 0.0886822706427791 no 3063 0.0841282545228756 4473 2892008 SGTC_1798 st045719 60.953 µM -1.38112281357753 0.0881631797891072 no 3064 0.0836206010736319 4379 3980186 SGTC_1667 st014849 34.6 µM -1.38294395991849 0.0878772666744382 no 3065 0.0833410248719993 4503 5348460 SGTC_1527 coumarin 137 µM -1.38406494780661 0.0877016199724167 no 3066 0.0831692843325693 4464 323 A hepatotoxic, DNA x-linker. SGTC_2118 5526350 200 µM -1.38504412523631 0.0875484078682244 no 3067 0.0830194876787935 4444 743594 SGTC_1840 st055363 71 µM -1.38924995158965 0.0868925922989157 no 3068 0.0823783785021421 4456 676033 SGTC_600 1495-0418 41.6 µM -1.38960291114514 0.0868377226042607 no 3069 0.0823247456365479 4410 5377768 SGTC_1941 st076221 61.8 µM -1.39050876776595 0.0866970202059959 no 3070 0.0821872193713336 4301 2828568 SGTC_2646 retinol 96.75 µM -1.39110372444499 0.0866047011603874 no 3071 0.0820969878282038 4423 445354 A vitamin A analog and teratogen. SGTC_3031 9088762 49.47 µM -1.39228700348371 0.0864213109418314 no 3072 0.0819177527485499 4409 205253 SGTC_1046 2001-0062 216 µM -1.39273495950014 0.086351960406555 no 3073 0.0818499764125246 4391 739778 SGTC_402 epigallocatechin gallate 10 µM -1.39820188076421 0.085508946573641 no 3074 0.081026226081664 4383 65064 An antioxidant. SGTC_1031 k035-0009 16 µM -1.40334144816128 0.0847220466077792 no 3075 0.0802575219980459 4467 5180959 SGTC_818 4072-2707 53.5 µM -1.40632975026816 0.08426702239602 no 3076 0.0798131149370392 4356 882871 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.40833935914639 0.0839620553665757 no 3077 0.0795153031346081 4484 91467 include heat shock SGTC_29 0299-0004 12.984 µM -1.41150283338427 0.0834836644405861 no 3078 0.0790482003752671 4344 16871 A napthoquinone isolated from Swertia calycina. SGTC_535 2293-4129 48.2 µM -1.41293243673539 0.083268148382215 no 3079 0.0788377953142113 4446 396118 YIL048W NEO1 SGTC_1739 st037196 92.5 µM -1.41431462420516 0.0830601783390614 no 3080 0.0786347724814226 4463 612214 SGTC_3015 9080845 49.47 µM -1.41447101464231 0.0830366717647623 no 3081 0.0786118260225597 4506 5296973 SGTC_285 1486-1325 46 µM -1.41458524896579 0.0830195047110069 no 3082 0.0785950681465476 4479 22310230 SGTC_2978 9011784 42.97 µM -1.41653724651493 0.0827265722777097 no 3083 0.0783091334890231 4427 2994934 SGTC_309 k408-0051 1.48 µM -1.42486272802979 0.0814859124244051 no 3084 0.077098442750697 4379 3640463 SGTC_1657 st012939 43.4 µM -1.4274053893473 0.0811098171662275 no 3085 0.0767315391508207 4451 24207257 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.42902705251591 0.0808706355116514 no 3086 0.0764982290805092 4454 229346 A bile salt which induces apoptosis. SGTC_3214 9129694 49.47 µM -1.43159201512918 0.0804934128564594 no 3087 0.0761303080758121 4473 17158655 SGTC_443 clozapine 122 µM -1.43366596670085 0.0801893751104752 no 3088 0.0758338043510141 4447 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2227 7312221 64.1025 µM -1.44010824901332 0.079250483075991 no 3089 0.0749183878261116 4573 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2284 7945075 39.21 µM -1.44250263311903 0.0789036573076664 no 3090 0.0745803146547623 4423 1245402 SGTC_3087 9117406 49.47 µM -1.44495368133337 0.0785498159560732 no 3091 0.0742354481853687 4475 42546093 SGTC_1007 4101-0031 70 µM -1.44602600210933 0.0783953909639537 no 3092 0.0740849544277217 4445 1146276 SGTC_1910 st062352 60.4 µM -1.44716916564269 0.0782310175162719 no 3093 0.073924775102731 4372 2245730 SGTC_1062 mesoridazine 14.2 µM -1.44904171704707 0.0779623316342121 no 3094 0.0736629663960985 4510 4078 A neuroleptic. SGTC_2196 6573537 42.6665 µM -1.45071957493877 0.0777221769547752 no 3095 0.0734289812005161 4490 2903087 SGTC_2246 7293507 91.5585 µM -1.45225557440221 0.0775028194448261 no 3096 0.0732152775915316 4511 887656 SGTC_3108 9121785 49.47 µM -1.45286680247072 0.0774156602791632 no 3097 0.0731303699036505 4338 17140271 SGTC_1625 st003711 30.1 µM -1.45378558239664 0.0772847852882956 no 3098 0.0730028809634219 4480 24207034 YER133W GLC7 SGTC_431 k089-0097 107 µM -1.45403464052215 0.0772493373431 no 3099 0.0729683512411391 4194 5499420 SGTC_269 exalamide 29 µM -1.45570685771231 0.0770116538248234 no 3100 0.0727368366657448 4417 3316 A derivative of salicylamide. SGTC_601 0986-0029 62.9 µM -1.46675782490073 0.0754548582722815 no 3101 0.0712209732044511 4444 24747981 SGTC_749 1000-0129 128 µM -1.47228751446971 0.0746849267705726 no 3102 0.0704716267273296 4499 708470 SGTC_990 3985-0011 41.3 µM -1.47389796323047 0.0744618255350434 no 3103 0.0702545331186057 4446 5399565 YGL099W LSG1 SGTC_2427 5545055 42.75 µM -1.4841377394162 0.0730551579433906 no 3104 0.0688861914920917 4420 5372858 SGTC_244 nsc-207895 1.295 µM -1.48546613088217 0.0728741732201686 no 3105 0.0687101944431987 4269 42640 SGTC_642 0335-0876 158 µM -1.48672416545124 0.0727030908113664 no 3106 0.0685438387762902 4521 6812350 SGTC_2292 7671323 168.05 µM -1.48695695630363 0.0726714669091438 no 3107 0.0685130898688257 4504 937504 SGTC_2130 NSC 7 2.4545 µM -1.48914117192796 0.0723752610230735 no 3108 0.0682250990038932 4531 21448 SGTC_397 arbidol 50 µM -1.48980271948407 0.0722857299882227 no 3109 0.0681380579385454 4508 131410 A RNA synthesis inhibitor. SGTC_2705 st078069 42.8 µM -1.49453321028949 0.0716479969310549 no 3110 0.0675181541828842 4498 1530061 SGTC_1642 st009582 77.7 µM -1.49808332328417 0.0711722364032077 no 3111 0.0670558016703715 4481 6739311 SGTC_3326 9140064 16.379 µM -1.49833051349331 0.0711392002998111 no 3112 0.0670237000148531 4450 1868434 SGTC_2216 7189485 200 µM -1.50238312227724 0.0705992608662325 no 3113 0.0664990963101613 4509 731273 SGTC_499 genistein 192 µM -1.50278096011423 0.0705464261537418 no 3114 0.0664477686620076 4587 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1204 4049-0315 18.3 µM -1.50339942986572 0.0704643508549675 no 3115 0.0663680367661975 4518 588402 SGTC_1917 st066507 28.5 µM -1.50433564109144 0.0703402487147765 no 3116 0.0662474832405841 4447 3156428 SGTC_558 k064-0027 21.3 µM -1.50719212175075 0.0699626383852551 no 3117 0.0658807095277003 4503 5088526 SGTC_1100 amiodarone 5.07 µM -1.50724796953208 0.0699552712060795 no 3118 0.0658735543579808 4532 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_9 0092-0002 10.449 µM -1.51032353861016 0.0695504773592029 no 3119 0.0654804441605348 4499 759368 SGTC_442 cape 100 µM -1.51107248777779 0.0694521773377092 no 3120 0.0653849916962417 4524 5281787 SGTC_572 0960-0087 17.7 µM -1.51349270160838 0.0691352542961154 no 3121 0.0650772768184457 4450 6796365 SGTC_1865 st057639 52.2 µM -1.51439379389823 0.0690175428376452 no 3122 0.0649629961856455 4500 688818 SGTC_457 grayanotoxin iii 135 µM -1.51522996586319 0.0689084502803388 no 3123 0.0648570884517153 4314 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1815 st051655 58.2 µM -1.51972024898415 0.0683248902323453 no 3124 0.0642906501036266 4459 5984156 SGTC_1784 st039334 36.3 µM -1.52013218829742 0.0682715458905232 no 3125 0.0642388780933221 4497 3496984 SGTC_2736 butenafine 14.65 µM -1.52472463540173 0.0676790185241285 no 3126 0.063663897212552 4456 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2858 9025781 8.96 µM -1.52574920477099 0.0675473700175007 no 3127 0.0635361676330008 4350 4894980 YPL153C RAD53 SGTC_1925 st057770 10.1 µM -1.52589714326753 0.0675283775305075 no 3128 0.063517741131777 4506 5989122 SGTC_419 nsc-638432 893 µM -1.52594199961982 0.067522619644074 no 3129 0.0635121548639626 4476 368090 SGTC_2964 9083345 53.42 µM -1.52657746290767 0.0674410905563589 no 3130 0.0634330573515555 4472 17741579 SGTC_2763 lisinopril 49.32 µM -1.52666699089785 0.0674296103523097 no 3131 0.0634219197704913 4410 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2853 9015042 58.44 µM -1.5285779290226 0.0671849301314201 no 3132 0.0631845554816212 4445 6457456 SGTC_1495 4469-0029 237 µM -1.53427475093506 0.0664595710712334 no 3133 0.0624810373092206 4515 793680 SGTC_162 k030-0015 37.8 µM -1.53746704256015 0.0660557652144361 no 3134 0.0620894898807139 4565 1809920 YMR134W ERG29 SGTC_353 1988-1175 58.3 µM -1.53796358768512 0.0659931264070778 no 3135 0.0620287590401313 4330 2788357 SGTC_698 k064-0052 127 µM -1.54569299300827 0.0650239912300536 no 3136 0.061089365154946 4596 5088751 SGTC_661 1304-0007 33.6 µM -1.55924725001533 0.0633512335769411 no 3137 0.0594689357312576 4545 3117130 SGTC_1057 3448-5381 134 µM -1.56290646327427 0.0629054347052192 no 3138 0.0590372986096244 4501 5497911 SGTC_1308 1187-1617 41.4 µM -1.57137375980428 0.0618832435036113 no 3139 0.0580479286794603 4556 2882570 SGTC_288 1315-0019 35.1 µM -1.57145560425643 0.0618734266989089 no 3140 0.0580384294571171 4560 6811474 SGTC_2449 5812982 45.77 µM -1.57250995359272 0.0617470717879596 no 3141 0.0579161663034404 4468 776185 SGTC_909 3448-9333 149 µM -1.57603695323326 0.061325854142976 no 3142 0.0575086436149908 4458 3344074 SGTC_659 k018-0002 107 µM -1.57864335435622 0.0610160254472608 no 3143 0.0572089422357778 4505 6797879 YHR007C ERG11 SGTC_1915 st067105 30.6 µM -1.58075855608429 0.0607654872644217 no 3144 0.0569666269630233 4478 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2569 tetrandrine 100 µM -1.58558745403307 0.0601965364575782 no 3145 0.0564164620357074 4533 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2491 paeonol 100 µM -1.58620385386515 0.0601242120741134 no 3146 0.0563465369259179 4511 11092 Increases levels of cortical cytochrome oxidase. SGTC_1306 1185-0270 9.02 µM -1.586414998749 0.0600994533440673 no 3147 0.0563226001211522 4548 1548076 SGTC_646 4092-0839 27.3 µM -1.58992795393042 0.0596886964175976 no 3148 0.0559255228796695 4560 877796 SGTC_1892 st058411 7.36 µM -1.59333493890292 0.0592924345483089 no 3149 0.0555425363244742 4545 3934738 SGTC_2221 6807166 181.081 µM -1.59388671056266 0.0592284532549797 no 3150 0.0554807057449265 4536 674925 SGTC_1772 st048439 82.2 µM -1.59716640892059 0.0588492688660172 no 3151 0.0551143091310182 4576 2927068 YDL195W SEC31 SGTC_3350 9150499 3.57 µM -1.60302256964019 0.0581769455140944 no 3152 0.0544648356472889 4550 4910996 YPR165W RHO1 SGTC_3044 9093193 49.47 µM -1.60428909228942 0.0580323376711028 no 3153 0.0543251721536594 4545 25236277 SGTC_105 0111-0055 734.78 µM -1.61042800960827 0.0573354131041353 no 3154 0.0536522249542818 4560 5179370 SGTC_1546 5-methoxyflavanone 78.7 µM -1.61403422928533 0.0569290955779844 no 3155 0.0532600009704563 4576 147795 SGTC_2126 5251174 33.877 µM -1.61589032057313 0.0567208529571012 no 3156 0.0530590143742519 4526 790722 SGTC_1137 ixabepilone 100 µM -1.61597157372317 0.0567117505544117 no 3157 0.0530502296472609 4510 154225 A novel microtubule stabilizer. SGTC_2940 9060638 45.86 µM -1.61630411836678 0.0566745091558934 no 3158 0.0530142884273747 4525 4027022 SGTC_76 0433-0009 400.328 µM -1.62609548080954 0.0555865930923712 no 3159 0.0519646726302804 4594 2841569 SGTC_1094 duloxetine 25.4 µM -1.62773239602688 0.0554063347834672 no 3160 0.0517908203536575 4567 60834 A selective serotonin reuptake inhibitor. SGTC_554 4483-2211 187 µM -1.62898927743063 0.0552682395898909 no 3161 0.0516576444386224 4599 747107 SGTC_2084 5306078 60.6385 µM -1.63579001599018 0.0545257424788856 no 3162 0.0509417711411847 4502 679340 SGTC_2322 7413319 38.22 µM -1.64345185118214 0.0536987061692801 no 3163 0.050144739794562 4505 1840400 SGTC_2277 7947813 106.88 µM -1.64462917027509 0.0535725089103813 no 3164 0.0500231537567622 4579 1246798 SGTC_97 0535-0701 19.132 µM -1.64694891659091 0.0533245421054669 no 3165 0.0497842730782427 4471 2832013 YGL099W LSG1 SGTC_529 4076-0302 30.3 µM -1.64915360309727 0.0530897184586574 no 3166 0.0495580852074596 4542 5816522 SGTC_2339 9000433 200 µM -1.65119073650129 0.0528734706314828 no 3167 0.0493498170278534 4527 2988954 SGTC_360 0957-0399 1.01 µM -1.656952374575 0.0522656366840824 no 3168 0.0487645520995738 4584 6752301 YPR165W RHO1 SGTC_2432 5630864 12.22 µM -1.66110134697743 0.0518313803208327 no 3169 0.0483465470010062 4564 5714970 SGTC_2877 9040724 71.43 µM -1.66637191551744 0.0512838715426275 no 3170 0.0478196804765489 4532 6463895 SGTC_1571 st070080 73.4 µM -1.66953397875191 0.0509576097033872 no 3171 0.0475058011165955 4565 4315245 SGTC_3025 9087895 49.47 µM -1.66997450901561 0.0509122871875364 no 3172 0.0474622035642528 4563 17173641 SGTC_1581 himbacine 57.9 µM -1.67005157880166 0.0509043614137707 no 3173 0.0474545795654632 4580 5281825 An alkaloid muscarinic receptor antagonist. SGTC_3201 9113999 49.47 µM -1.67036662521672 0.0508719725938854 no 3174 0.0474234243323188 4547 16649224 SGTC_99 0109-0120 622.8 µM -1.67503096350813 0.0503943653457647 no 3175 0.0469640783380956 4578 759414 SGTC_970 1315-0089 19.5 µM -1.68048509622714 0.0498404259173645 no 3176 0.0464314858280614 4564 6811083 YLR033W RSC58 SGTC_1549 4'-methoxyflavonol 74.6 µM -1.69534483438711 0.0483558407976164 no 3177 0.0450050121600341 4565 97141 SGTC_2752 diclazuril 33.15 µM -1.69947699147494 0.0479493579651049 no 3178 0.0446146730991137 4501 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1548 st061468 90.8 µM -1.70451089846991 0.0474578700232115 no 3179 0.0441428408701512 4640 390799 SGTC_2100 5377183 190 µM -1.70815708384465 0.0471043999136989 no 3180 0.0438035996296221 4611 2844202 SGTC_2675 theaflavin digallate 100 µM -1.71062097829204 0.0468667412723144 no 3181 0.0435755518859684 4535 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_313 3474-0040 5.03 µM -1.71110100961232 0.0468205512596446 no 3182 0.0435312339191058 4607 1043375 YIL048W NEO1 SGTC_679 0422-0091 41.4 µM -1.7177599186767 0.0461835707257375 no 3183 0.0429202075671598 4619 627384 YHR062C RPP1 SGTC_469 w7 172 µM -1.71876962628495 0.0460875942432085 no 3184 0.0428281641209767 4693 45115570 A P450 inhibitor. SGTC_408 cantharidin 100 µM -1.7225598364731 0.0457287491997533 no 3185 0.0424840766721913 4594 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2917 7979103 53.79 µM -1.73060984408568 0.0449740503129244 no 3186 0.0417606873732551 4589 2980565 SGTC_2784 7567673 72.73 µM -1.73503734414696 0.0445632592232504 no 3187 0.0413670954353997 4525 3471247 SGTC_3052 9092717 49.47 µM -1.73756991440635 0.0443296452949609 no 3188 0.0411433124342294 4600 25237534 SGTC_2389 9091542 195.52 µM -1.74108425914188 0.0440071048830443 no 3189 0.0408344050455373 4571 3626624 YOL127W RPL25 SGTC_145 3737-0113 38.366 µM -1.74451665425086 0.0436939150760014 no 3190 0.0405345199669308 4584 6849351 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.75150371868323 0.043061935600777 no 3191 0.0399295906484348 4492 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1431 4049-0260 9.09 µM -1.7546834868645 0.0427767810920032 no 3192 0.0396567310628447 4640 3854841 SGTC_470 aa-861 153 µM -1.76061185532502 0.0422492147438377 no 3193 0.0391520603415623 4566 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2867 9039098 71.43 µM -1.77098193906484 0.0413390467742492 no 3194 0.0382818525774257 4595 6463460 SGTC_1695 st026914 34.495 µM -1.77951578248956 0.04060202088276 no 3195 0.0375776198692838 4620 3289191 SGTC_2888 9058547 12.99 µM -1.78179336035005 0.0404071312931091 no 3196 0.0373914677099918 4556 16476514 SGTC_1184 1269-1718 139 µM -1.78272106001916 0.0403279671703279 no 3197 0.0373158606843079 4660 5403821 SGTC_213 1246-0773 967 nM -1.78531485954128 0.0401072966578327 no 3198 0.03710512996325 4643 6251622 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.78927176697833 0.0397725489453393 no 3199 0.036785529311396 4655 16486 A toxic proline analog. SGTC_2776 terbinafine 19.92 µM -1.79381184080846 0.0393912683089322 no 3200 0.0364216031841138 4625 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2717 st081029 62.2815 µM -1.79710739715607 0.0391163707066181 no 3201 0.0361592858079478 4602 5292846 SGTC_1597 7-benzyloxygramine 47.5 µM -1.80136219593171 0.0387637700214908 no 3202 0.0358229053023252 4524 260807 SGTC_2272 7805186 180 µM -1.80245621352078 0.0386735270380165 no 3203 0.0357368289045253 4627 2956062 YPR165W RHO1 SGTC_1700 st030840 7.9285 µM -1.80446425124911 0.0385083340890786 no 3204 0.0355792792445529 4658 5499307 SGTC_1640 st009078 66.4 µM -1.80702786274631 0.0382982726214657 no 3205 0.0353789674833088 4612 690618 SGTC_2161 5662504 8.5105 µM -1.81394743781452 0.0377359458152017 no 3206 0.0348429092037622 4627 2859334 SGTC_1671 st016596 74.5 µM -1.82424191253243 0.0369118425539471 no 3207 0.0340577538983709 4679 2829167 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.82656338791667 0.0367280494717963 no 3208 0.0338827212048199 4635 688662 SGTC_526 4469-0568 170 µM -1.82752315821611 0.0366522826904284 no 3209 0.0338105737520375 4615 2901964 SGTC_2385 9074692 200 µM -1.83825980219406 0.0358133878215301 no 3210 0.0330120657004269 4638 17046906 SGTC_1773 st048542 73.5835 µM -1.84016271662967 0.03566635991717 no 3211 0.0328721759379847 4616 3237138 SGTC_902 1120-0002 2.07 µM -1.84469041468056 0.0353185174791645 no 3212 0.032541293010306 4628 3280475 SGTC_1985 st071382 65.5 µM -1.84903983847347 0.0349869960732975 no 3213 0.0322260301956622 4641 6123237 SGTC_2382 9035899 200 µM -1.8574094306994 0.0343562359617958 no 3214 0.0316264628869347 4638 6462679 SGTC_2172 5754775 163.918 µM -1.87027396721811 0.0334049676280679 no 3215 0.0307228913504427 4631 2263357 SGTC_1731 st035964 63 µM -1.87890610148109 0.0327789043922745 no 3216 0.0301286577939628 4558 6739575 SGTC_1134 3477-0009 42.5 µM -1.8866875783281 0.0322228578740066 no 3217 0.0296011796967508 4646 3973534 SGTC_2224 6650123 117.647 µM -1.88881456579093 0.0320722304412432 no 3218 0.0294583401690973 4707 2908370 SGTC_1707 st032323 6.317 µM -1.91928757231037 0.0299773201670768 no 3219 0.0274739749703141 4478 3132057 YMR211W DML1 SGTC_2206 7254556 146.969 µM -1.9233008551008 0.0297100738516279 no 3220 0.0272211386354734 4684 4398905 SGTC_2549 cedrol 20.94 µM -1.92592728153038 0.0295362514252489 no 3221 0.0270567272035873 4643 6708665 A sedative which affects the nervous system. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.92678299122028 0.0294798014029041 no 3222 0.0270033400223672 4639 5379071 SGTC_406 estrone 100 µM -1.92763330489436 0.0294237960973455 no 3223 0.0269503766156742 4648 5870 A steroid. SGTC_3094 9117742 49.47 µM -1.93211068552355 0.0291303519482056 no 3224 0.0266729228644771 4632 17149698 SGTC_445 e6 berbamine 66 µM -1.93228492049309 0.0291189820455321 no 3225 0.0266621743013486 4668 6610268 A calcium/calmodulin antagonist. SGTC_2354 9060492 162 µM -1.93441585654569 0.0289802234217757 no 3226 0.0265310092130398 4657 6471895 SGTC_1874 staurosporine 7.6 µM -1.93453178168561 0.0289726905951913 no 3227 0.026523889185259 4659 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2843 9000894 45.46 µM -1.93462825606463 0.0289664229215628 no 3228 0.0265179650246131 4680 2242070 SGTC_2691 st077356 60.2 µM -1.93996798754839 0.0286212684998179 no 3229 0.0261917902428879 4632 2839272 SGTC_3216 9129716 49.47 µM -1.94373920204695 0.0283795678952054 no 3230 0.0259634543421508 4587 8056934 SGTC_3250 9135583 49.47 µM -1.94545315684057 0.028270281657165 no 3231 0.0258602311682934 4676 7699353 SGTC_3055 9094636 49.47 µM -1.95605251165351 0.0276021940234694 no 3232 0.0252294842507259 4664 25236176 SGTC_2102 5377816 72.7585 µM -1.95703387353089 0.027541009044938 no 3233 0.0251717429774544 4687 1379702 SGTC_1510 1123-0200 71.5 µM -1.95763590471081 0.0275035301879978 no 3234 0.0251363755660867 4667 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_954 1189-0853 2.85 µM -1.96040532489522 0.0273316699593243 no 3235 0.0249742169858773 4626 2828194 SGTC_617 3770-0098 35 µM -1.96144652837406 0.0272672887216924 no 3236 0.0249134784190131 4618 5962639 SGTC_2912 7964298 10.93 µM -1.96701431949875 0.0269251560965374 no 3237 0.0245907799782206 4652 2975850 SGTC_1524 corynanthine 62.1 µM -1.97216439936865 0.0266118888770996 no 3238 0.024295421136816 4706 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1675 st018485 24.5 µM -1.9857088123287 0.025802518666403 no 3239 0.0235328329734814 4668 3323024 SGTC_301 4119-0100 24.5 µM -1.99037810081314 0.0255283159735573 no 3240 0.0232746502056914 4688 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1852 st056254 31.4 µM -1.99160488124907 0.025456679750164 no 3241 0.0232072136945977 4668 442583 SGTC_789 1309-1135 70.6 µM -2.00061610002536 0.0249356251975709 no 3242 0.0227168885998786 4668 3092424 SGTC_2087 5276107 200 µM -2.00127755956006 0.0248977325881215 no 3243 0.0226812433382859 4683 144405 SGTC_2239 6685329 187.64 µM -2.01937196355039 0.0238797469609474 no 3244 0.0217242866519121 4659 805680 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.02023661261468 0.0238319909923156 no 3245 0.0216794251234545 4669 4000243 SGTC_2291 7917025 104.35 µM -2.04367953853876 0.0225674734358436 no 3246 0.0204926079460979 4619 2964612 SGTC_379 3970-0972 5.9 µM -2.04568172685037 0.0224621468762559 no 3247 0.0203938473628261 4693 2898042 YBL034C STU1 SGTC_1803 st050068 52.4 µM -2.05378858635572 0.0220399074639855 no 3248 0.0199980790536738 4693 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1014 4130-3005 69.3 µM -2.05418665698893 0.0220193480157684 no 3249 0.0199788146625369 4698 743608 SGTC_882 0843-0131 351 µM -2.05432549950679 0.0220121809229807 no 3250 0.0199720991659597 4713 5425421 SGTC_2413 inermin 26.06 µM -2.0556901411338 0.021941842453857 no 3251 0.0199061964090794 4690 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1415 3966-0071 78.1 µM -2.05980054428328 0.0217311234043626 no 3252 0.0197088062666872 4635 2893185 SGTC_392 N-ethylmaleimide 8.33 µM -2.06037989816883 0.0217015608421794 no 3253 0.0196811185425084 4691 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1331 1472-0049 76.2 µM -2.06222850771477 0.0216074593230786 no 3254 0.0195929929081432 4694 24051409 SGTC_444 curcumin 90.4 µM -2.07349510178925 0.0210413696900318 no 3255 0.0190631132495097 4612 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_739 1486-1183 203 µM -2.08047284782918 0.0206971052583582 no 3256 0.0187410917858976 4698 4346692 SGTC_1410 3909-8106 77.9 µM -2.09176157524457 0.0201502524049296 no 3257 0.0182299246119609 4740 1039210 SGTC_1774 st048371 48.465 µM -2.09246721009268 0.0201164805195936 no 3258 0.0181983709985455 4693 4242727 SGTC_2963 9082507 9 µM -2.09678945754392 0.0199106624094838 no 3259 0.0180061086256823 4670 16459611 SGTC_582 0987-0078 156 µM -2.10114467402097 0.0197050844623167 no 3260 0.0178141341579695 4725 1625765 SGTC_1107 amlodipine 47 µM -2.10729241985742 0.0194179633929539 no 3261 0.0175461200070574 4289 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_268 camptothecin 39.6153 µM -2.11393323212024 0.0191118154654419 no 3262 0.0172604851910207 4652 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_293 4049-0273 38.5 µM -2.13189462383229 0.018304265883219 no 3263 0.016507755144539 4630 1380311 SGTC_943 3253-1379 105 µM -2.15031450967238 0.0175064794123556 no 3264 0.0157651727252809 4688 668464 SGTC_762 1165-0429 115 µM -2.15209167280516 0.0174311028189887 no 3265 0.0156950674390819 4718 5967793 SGTC_1879 gemcitabine 100 µM -2.17293728357203 0.0165674494168408 no 3266 0.0148925189418866 4700 60750 A nucleoside analog which inhibits DNA replication. SGTC_1522 st012842 45.6 µM -2.17620906556358 0.0164352775845085 no 3267 0.0147698156780943 4588 3491067 YOR116C RPO31 SGTC_3152 9099253 49.47 µM -2.1875421726325 0.0159844052555182 no 3268 0.014351484030408 4579 25236131 SGTC_1028 k015-0029 4.8 µM -2.18917825222951 0.0159201999861314 no 3269 0.0142919433460794 4719 4588309 SGTC_2537 larixol 68.93 µM -2.20024539922147 0.0154916676935627 no 3270 0.013894744425635 4703 6708759 SGTC_2050 5263056 171 µM -2.21198263252297 0.0150480451053563 no 3271 0.0134839324872218 4698 763468 YGL055W OLE1 SGTC_1152 3909-8331 15.9 µM -2.22449218751889 0.0145872943757668 no 3272 0.0130576737793482 4730 16001939 SGTC_246 cycloheximide 667 µM -2.23582752200301 0.0141803288464151 no 3273 0.0126815356945303 4723 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1628 st004252 77.7 µM -2.25921974125792 0.013371323011477 no 3274 0.0119348597133967 4725 692968 SGTC_3283 9109332 35.8195 µM -2.26321052052586 0.0132373606675182 no 3275 0.0118113575024636 4620 17027281 SGTC_867 0518-0118 155 µM -2.26792515320524 0.0130805954859772 no 3276 0.0116668844835165 4716 6848158 SGTC_3178 9107506 49.47 µM -2.27767298215813 0.012761554617288 no 3277 0.0113730343093629 4713 8897194 SGTC_2515 chrysin 20.77 µM -2.28128346953336 0.0126451058053736 no 3278 0.0112658391273183 4742 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1800 st050079 29.0735 µM -2.28381365366116 0.0125640490191055 no 3279 0.0111912424490765 4607 3645560 SGTC_1310 1188-0297 994 nM -2.2991250560909 0.0120830674054325 no 3280 0.0107489195422541 4674 1588352 SGTC_1556 plumbagin 1.48 µM -2.32564282736494 0.0112877648986134 no 3281 0.0100188064214868 4701 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_515 4092-1064 102 µM -2.32625478129952 0.0112699618460122 no 3282 0.0100024813896588 4692 717353 SGTC_746 1095-0025 46.6 µM -2.34198946521085 0.0108205130785045 no 3283 0.0095906281671498 4748 6749286 SGTC_178 4092-0806 87.505 µM -2.3448698103452 0.0107399498794297 no 3284 0.00951686222105041 4643 2169044 SGTC_889 0919-1524 82.7 µM -2.34579851173771 0.010714085702528 no 3285 0.0094931840700728 4760 3905452 SGTC_2943 9068529 45.32 µM -2.34973939910469 0.0106049351276225 no 3286 0.00939327943821567 4704 3270634 SGTC_513 4245-1575 41.7 µM -2.35612262859767 0.0104301938393075 no 3287 0.0092334101666437 4609 719745 SGTC_2688 kanamycin b 96.69 µM -2.35637002299796 0.0104234722170675 no 3288 0.00922726235043978 4690 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3068 9116768 49.47 µM -2.35960862633908 0.0103358280662075 no 3289 0.00914711201370639 4708 41904888 SGTC_768 0384-0033 77.3 µM -2.37323777070961 0.00997399575745292 no 3290 0.0088164544005644 4729 3965305 YMR134W ERG29 SGTC_367 0335-0881 7.1 µM -2.37365733411467 0.00996303467905675 no 3291 0.00880644375065117 4685 23828853 SGTC_1396 3511-0007 98.6 µM -2.37764498566286 0.00985938125751241 no 3292 0.00871179590852274 4748 X1396 SGTC_320 4092-0846 5.34 µM -2.37822832797893 0.00984429732064141 no 3293 0.00869802519211671 4726 1359356 SGTC_1981 st071826 47 µM -2.37934964816528 0.00981535906645755 no 3294 0.00867160825943752 4758 11838600 SGTC_2681 menadione 3.18 µM -2.3987056872456 0.00932741427337703 no 3295 0.00822656650892895 4762 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1145 3546-0597 10.2 µM -2.40177747911269 0.00925196139315266 no 3296 0.00815781491984222 4741 875334 SGTC_3278 9139605 49.47 µM -2.40189086285404 0.00924918658292717 no 3297 0.0081552869013694 4733 7958859 SGTC_3197 9113331 49.47 µM -2.41202836925753 0.00900401913510306 no 3298 0.00793202354927108 4725 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1155 4088-0394 48.2 µM -2.47684871181265 0.00756679768653018 no 3299 0.00662740365626611 4765 2326248 SGTC_2003 4023581 200 µM -2.50242893339016 0.00705777143726993 no 3300 0.00616721929688224 4748 16641307 SGTC_2193 5925765 200 µM -2.51215262259075 0.00687235248880936 no 3301 0.00599985896843459 4771 877370 SGTC_2240 6690706 185.951 µM -2.52047559512497 0.00671707439588566 no 3302 0.00585981824602656 4716 805876 SGTC_1626 st003712 1.76 µM -2.52873725046942 0.00656601482444445 no 3303 0.00572368444878026 4753 24207035 SGTC_1990 st072050 59.8 µM -2.5360957769336 0.00643400605689537 no 3304 0.00560480357117574 4771 17233948 SGTC_2586 curcumin 80 µM -2.54388953135576 0.00629675539096849 no 3305 0.00548128742329738 4692 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2009 4012297 12.05 µM -2.54705285071336 0.0062417919749946 no 3306 0.00543184893955273 4732 45595307 SGTC_3141 9094609 49.47 µM -2.57441604051129 0.00578380800180068 no 3307 0.00502047265448711 4755 25236309 YDL196W YDL196W SGTC_1379 2144-0755 36.5 µM -2.5825945216984 0.00565283743101048 no 3308 0.00490302482794465 4770 5392327 SGTC_982 1491-0518 27.5 µM -2.61013721956384 0.00523092281531404 no 3309 0.00452529553531923 4765 3091256 SGTC_2333 9017922 200 µM -2.62996333766972 0.00494479739822295 no 3310 0.0042697038408972 4747 3163164 SGTC_2021 4019055 173 µM -2.6368048357882 0.0048493484734003 no 3311 0.00418454832559471 4638 44827708 YER133W GLC7 SGTC_868 0527-0199 213 µM -2.66919253024958 0.004419423602218 no 3312 0.00380169261632014 4771 2849450 SGTC_649 1123-0311 367 µM -2.68367070037277 0.00423849972064512 no 3313 0.00364093954234583 4723 693629 YIL048W NEO1 SGTC_524 r073-0010 27.8 µM -2.69118423065953 0.00414724357209536 no 3314 0.00355994323024299 4750 2772106 SGTC_263 alizarin 107.927 µM -2.7162967488397 0.00385485800852305 no 3315 0.00330083582138474 4779 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2934 9036370 36.88 µM -2.74528250374529 0.00354044748122477 no 3316 0.00302294139449404 4758 6462800 SGTC_2398 5228213 48.84 µM -2.75879784655954 0.00340187595128032 no 3317 0.00290072053160318 4750 80771 YMR134W ERG29 SGTC_750 4073-0104 132 µM -2.76987508009779 0.00329195776467606 no 3318 0.0028038897795892 4601 22330957 SGTC_1321 1326-2144 215 µM -2.77586837049627 0.00323382802250045 no 3319 0.00275272463499131 4771 3513030 SGTC_2525 harmine 47.85 µM -2.84771846095209 0.00260542216093844 no 3320 0.00220169301777949 4791 5280953 A monoamine oxidase inhibitor SGTC_2909 7941780 10.49 µM -2.93032289679245 0.00202080361196068 no 3321 0.00169304974227016 4779 1243215 SGTC_2900 5328528 85.29 µM -2.93494740782211 0.00199190139307009 no 3322 0.0016680211292272 4763 795359 SGTC_2267 7931562 200 µM -2.98843117386794 0.00168386971183446 no 3323 0.00140206824734781 4771 934880 SGTC_1767 st044992 70.3 µM -3.00903039969974 0.00157728982788833 no 3324 0.00131041445289433 4791 9600693 SGTC_2068 5226020 147 µM -3.04156567079822 0.00142142368850976 no 3325 0.00117675610051251 4784 1810509 SGTC_1547 harmine 94.2 µM -3.04615499833057 0.00140060695390062 no 3326 0.0011589415665818 4747 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_872 0588-0139 234 µM -3.08974815569982 0.00121631269003724 no 3327 0.00100163139826656 4784 2047100 SGTC_1754 st042065 16.137 µM -3.09681060917819 0.00118863637350586 no 3328 0.000978074036023511 4701 1126236 YIL048W NEO1 SGTC_3060 1327-0027 12.5 µM -3.11342374209948 0.00112579139968418 no 3329 0.00092465146653226 4758 16000455 YPR107C YTH1 SGTC_651 3253-0966 34.4 µM -3.12802124850126 0.00107309972262502 no 3330 0.000879937289689449 4796 781462 SGTC_1136 pergolide 1.05886 µM -3.14030613182148 0.00103051847677631 no 3331 0.000843856855983776 4774 47811 A dopamine receptor agonist. SGTC_2699 st077704 54.6 µM -3.18059332668496 0.000901520070883211 yes 3332 0.000734868951004129 4789 645852 SGTC_151 3013-0144 2.285 µM -3.20953964015216 0.000818186723485939 yes 3333 0.00066473856725342 4676 906558 YHR107C CDC12 SGTC_1926 methyl fluorone black 53.6 µM -3.22389798319193 0.000779536059893591 yes 3334 0.000632292207697051 4652 72721 Reacts with homocysteine. SGTC_299 1273-0059 1.44 µM -3.2264488297893 0.000772848017717782 yes 3335 0.000626683205474223 4668 2848077 SGTC_3294 9122953 26.2835 µM -3.25050945192592 0.000712313913645593 yes 3336 0.000575992195283001 4792 16459826 SGTC_660 4031-1742 102 µM -3.371740573376 0.000468525460198144 yes 3337 0.000373473856705994 4772 6738706 SGTC_2905 7799065 20.05 µM -3.45834453799441 0.000344524250592877 yes 3338 0.000271752921432266 4790 1296806 SGTC_2948 9070189 9.45 µM -3.46495605841391 0.000336438431844901 yes 3339 0.000265159060849033 4780 6473636 YDL196W YDL196W SGTC_1712 st032288 53.4 µM -3.56403594779394 0.000234568344490335 yes 3340 0.000182597954074607 4746 2883011 SGTC_1660 st012960 28.1 µM -3.71007355363088 0.00013561660954185 yes 3341 0.000103599520063435 4807 24207266 SGTC_2514 salinomycin 42.74 µM -3.87975114717385 7.00165413529392e-05 yes 3342 5.22816938719989e-05 4805 23682228 A polyether potassium ionophore. SGTC_1325 1431-0015 227 µM -3.88974009999353 6.72885422219714e-05 yes 3343 5.01758193873414e-05 4808 1103340 SGTC_1327 1436-0082 2.18 µM -3.99956025450232 4.32079020851663e-05 yes 3344 3.17301448599502e-05 4810 15992205 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -4.02856330277641 3.83665950165033e-05 yes 3345 2.80593753790348e-05 4789 4330530 SGTC_2930 9013230 14.89 µM -4.03041933109418 3.80749267320414e-05 yes 3346 2.7838717605156e-05 4797 2995857 SGTC_585 0kpi-0023 191 µM -4.05364346689627 3.45981540456666e-05 yes 3347 2.5213025374804e-05 4793 64601 SGTC_1658 st012944 20 µM -4.44617416051009 6.3602254621059e-06 yes 3348 4.37065447843369e-06 4797 24207260 SGTC_2953 9074162 66.49 µM -4.55073415293954 3.95447744419247e-06 yes 3349 2.67295290208178e-06 4805 16451992 SGTC_2128 5255449 168.493 µM -4.99386224446699 4.71453558332168e-07 yes 3350 2.95918096980541e-07 4799 736008 SGTC_1787 fluconazole 80 µM -5.06368328996086 3.31631609795067e-07 yes 3351 2.05616311163759e-07 4734 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2614 arthonioic acid 13.39 µM -5.25103689365061 1.26156094652541e-07 yes 3352 7.56226897581856e-08 4783 6710684 SGTC_1324 1418-0026 34.4 µM -6.19876535253872 5.73365565486137e-10 yes 3353 2.84538992079831e-10 4810 1372513