SGTCid condition conc unit RSC4|YKR008W.score RSC4|YKR008W.strain.pval RSC4|YKR008W.strain.significant RSC4|YKR008W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1044 1222-0021 1.78 µM 10.9752550585399 6.41815574197902e-25 yes 1 2.51319017581949e-28 4 4306703 SGTC_2322 7413319 38.22 µM 9.23065218321721 3.44730820566622e-18 yes 2 1.34494521863921e-20 7 1840400 SGTC_2225 6654152 15.4 µM 8.91921537113234 4.16453469781862e-17 yes 3 2.34801671092544e-19 11 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1036 k216-0215 33.5 µM 8.21958753310435 8.29661178551678e-15 yes 4 1.02102135613269e-16 1 622330 SGTC_2930 9013230 14.89 µM 7.57149292364294 7.70474716109964e-13 yes 5 1.84479586210242e-14 8 2995857 SGTC_1923 st058458 19.1 µM 7.51586444511327 1.11792873743036e-12 yes 6 2.82680547329517e-14 1 3534982 SGTC_2344 7990960 76.95 µM 6.514611514254 5.78742557773137e-10 yes 7 3.64390118941238e-11 16 140813 SGTC_69 0096-0274 206.684 µM 6.12714111815298 5.17147667281021e-09 yes 8 4.4736056262878e-10 22 6741392 SGTC_3081 9117243 49.47 µM 6.07752570222009 6.78299199150603e-09 yes 9 6.10255614870496e-10 12 45595589 SGTC_902 1120-0002 2.07 µM 5.82398978970484 2.62613653328143e-08 yes 10 2.8729544038486e-09 8 3280475 SGTC_331 k048-0133 24.5 µM 5.791640372634 3.10909340724863e-08 yes 11 3.48511336455262e-09 2 6813582 SGTC_1920 st075728 45.7 µM 5.63486116307212 6.95872010497358e-08 yes 12 8.75997125304392e-09 1 3400306 SGTC_1921 5740136 50 µM 5.5956065616473 8.48650938628157e-08 yes 13 1.0992588048017e-08 6 1774243 SGTC_525 k781-2675 26.7 µM 5.58200592435343 9.08789943485993e-08 yes 14 1.18880138506744e-08 26 3651118 YDL195W SEC31 SGTC_91 0417-1751 58.384 µM 5.57494342707997 9.41623387871215e-08 yes 15 1.23805159662051e-08 5 6795624 SGTC_16 erodoxin 22.806 µM 5.44859173707842 1.76423766898013e-07 yes 16 2.53851014562465e-08 14 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_262 fenpropimorph 62.5 µM 5.43006578506788 1.93218141078203e-07 yes 17 2.81666412476428e-08 9 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1098 clofazimine 15.1 µM 5.3521220421958 2.82373905063518e-07 yes 18 4.34643679957644e-08 12 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1 0258-0098 57.368 µM 5.29769217017229 3.66925459048238e-07 yes 19 5.86377275578159e-08 11 6790032 YDR047W HEM12 SGTC_547 1120-0019 610 nM 5.04444271011397 1.20130957037861e-06 yes 20 2.27422542091846e-07 5 3676939 SGTC_2856 9022925 19.48 µM 5.03188101878148 1.27232029754105e-06 yes 21 2.42845337851784e-07 1 4944862 SGTC_3327 9140648 26.9345 µM 4.85914747089736 2.76535570103481e-06 yes 22 5.89461490818825e-07 7 8029710 SGTC_2766 oltipraz 83.91 µM 4.54132169401515 1.08108262524842e-05 yes 23 2.79513272392989e-06 14 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1783 st039459 87.517 µM 4.40536379026705 1.88800185505468e-05 yes 24 5.28032472879448e-06 8 729761 SGTC_2564 betulinic acid 100 µM 4.40278777803134 1.90777003247686e-05 yes 25 5.34343464532212e-06 7 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1754 st042065 16.137 µM 4.31039051779192 2.76185319405452e-05 yes 26 8.14832484596943e-06 24 1126236 YIL048W NEO1 SGTC_2916 7875993 68.79 µM 4.27553238109737 3.16970877097621e-05 yes 27 9.53405412153074e-06 4 1299250 SGTC_1239 0337-0584 35.4 µM 4.2662159380146 3.28800899717445e-05 yes 28 9.94081774644408e-06 26 914301 YML130C ERO1 SGTC_1926 methyl fluorone black 53.6 µM 4.2486152348521 3.52299519140003e-05 yes 29 1.07547996866144e-05 24 72721 Reacts with homocysteine. SGTC_1785 bathophenanthroline 24 µM 4.21278853940855 4.05127210320316e-05 yes 30 1.26118592644477e-05 20 72812 An iron chelator. SGTC_3304 9125678 46.087 µM 4.21212005182834 4.06180663542838e-05 yes 31 1.2649250984054e-05 26 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2336 9001819 198.65 µM 4.11321851885468 5.94036541347807e-05 yes 32 1.95090362198135e-05 38 2989602 SGTC_288 1315-0019 35.1 µM 4.01177922899714 8.69965417669018e-05 yes 33 3.01314216286221e-05 23 6811474 SGTC_745 0469-0705 296 µM 4.00403367120232 8.95369085945525e-05 yes 34 3.1135747794151e-05 16 3486736 SGTC_2575 plumbagin 510 nM 3.94362262323099 0.000111881957158873 yes 35 4.01299614311953e-05 26 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3031 9088762 49.47 µM 3.93455500089198 0.00011565668968865 yes 36 4.1675490400095e-05 6 205253 SGTC_2066 5222451 176 µM 3.81175843284805 0.00018006787377604 yes 37 6.89908455977592e-05 23 2281147 SGTC_966 1300-0360 30.2 µM 3.80932645128894 0.000181630913450185 yes 38 6.96729378301002e-05 21 70588 SGTC_342 k048-0088 23.3 µM 3.76576038506946 0.000211871771908465 yes 39 8.30214883436997e-05 13 6820570 SGTC_1656 st012921 11 µM 3.73213777131674 0.000238357805874716 yes 40 9.49308028285006e-05 4 6732821 SGTC_2993 9054257 71.4286 µM 3.72055991606129 0.000248171478641308 yes 41 9.93907865039562e-05 34 6470217 YGL055W OLE1 SGTC_1027 k015-0025 8.67 µM 3.62427067492048 0.000345649751592879 yes 42 0.000144889002898499 7 3598955 SGTC_1031 k035-0009 16 µM 3.58375033052415 0.000396462645798012 yes 43 0.000169347924897095 3 5180959 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 3.52286449109347 0.000485973764718928 yes 44 0.000213454787090034 13 688788 SGTC_445 e6 berbamine 66 µM 3.49871022888315 0.0005264088491763 yes 45 0.000233757183986714 35 6610268 A calcium/calmodulin antagonist. SGTC_227 fluconazole 33.516 µM 3.44588586238821 0.000625914295488879 yes 46 0.000284595355998965 54 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2890 9046729 58.44 µM 3.43130456378842 0.000656291527979179 yes 47 0.000300342891886203 27 903329 SGTC_1893 st059353 36.1 µM 3.41920793532997 0.000682518793376725 yes 48 0.000314018567694449 10 3112488 SGTC_2268 7933382 153.85 µM 3.3805244081404 0.000773017257814944 yes 49 0.000361738245053 8 935025 YOR257W CDC31 SGTC_2248 tofa 1.1 µM 3.3347538351369 0.000894313306614209 yes 50 0.000426874702407911 38 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2812 7970281 58.44 µM 3.32783919679262 0.000914089032214889 yes 51 0.000437611848069157 16 2233435 SGTC_1278 0874-0585 172 µM 3.31381811314315 0.000955428021698361 yes 52 0.000460156763908878 15 766306 SGTC_1243 0416-0003 5.65 µM 3.30182336103387 0.000992147927171139 yes 53 0.000480292709546623 12 2141977 SGTC_2129 girgensonine 121.053 µM 3.25117301962543 0.00116193130400826 no 54 0.00057464946085222 36 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_327 1273-0057 3.96 µM 3.24521329388411 0.00118356864931276 no 55 0.000586813402246473 14 3108138 SGTC_3288 9119690 36.221 µM 3.24379840820937 0.00118875942019483 no 56 0.000589735954121098 24 17595618 YKL019W RAM2 SGTC_566 0958-0068 16.5 µM 3.23357405335345 0.00122689322470082 no 57 0.00061125818577953 25 6815365 SGTC_1846 st056244 14.8 µM 3.20740890199219 0.00132963437673145 no 58 0.000669682362988427 11 5393182 SGTC_533 1222-0222 6.71 µM 3.15231678772192 0.00157211904832636 no 59 0.000809902179801805 18 3982874 SGTC_1556 plumbagin 1.48 µM 3.11788918101368 0.00174345355560774 no 60 0.000910756399359869 32 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1637 st007924 17.4 µM 3.1161349952279 0.00175262234470215 no 61 0.000916191839468599 11 683336 SGTC_2044 5102272 200 µM 3.08143153788718 0.00194326847674035 no 62 0.00103003922254537 20 592666 SGTC_1695 st026914 34.495 µM 3.03760843352692 0.00221086054750589 no 63 0.00119231796785749 11 3289191 SGTC_2544 sphondin 68.51 µM 3.03662143093623 0.00221725446364124 no 64 0.0011962286073319 56 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_86 0417-1630 471.922 µM 3.00744971414374 0.00241396462772831 no 65 0.00131724853462396 46 3634867 SGTC_475 α-linolenic acid 10 µM 3.00547806685785 0.00242781299766498 no 66 0.00132581859574441 17 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.99617199848346 0.00249415172967861 no 67 0.0013669609000251 20 165506 SGTC_145 3737-0113 38.366 µM 2.97810518591666 0.00262764113057465 no 68 0.00145018214874142 76 6849351 SGTC_1557 sumaresinolic acid 42.3 µM 2.97681071654699 0.00263744890012435 no 69 0.00145631886769695 7 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2269 7935389 174.42 µM 2.95686251584766 0.00279282900553734 no 70 0.00155393329443845 16 97605 SGTC_2413 inermin 26.06 µM 2.95466800929886 0.00281041715910106 no 71 0.00156502837002255 34 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2705 st078069 42.8 µM 2.95056676398047 0.0028435552154255 no 72 0.00158595741911502 12 1530061 SGTC_3083 9117465 49.47 µM 2.94857021924496 0.00285981449115151 no 73 0.00159623802231713 18 16420915 SGTC_1528 arabinosylhypoxanthine 74.6 µM 2.94562362885927 0.00288396386751476 no 74 0.00161152158760143 21 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3338 9144300 39.5675 µM 2.94362874728954 0.00290041754810237 no 75 0.00162194433855981 9 4901274 SGTC_1260 0700-1617 7.75 µM 2.9349378400385 0.00297309164163642 no 76 0.00166807256193062 16 2853078 SGTC_1113 artemisinin 1.17947 µM 2.90966201590422 0.00319386894385317 no 77 0.001809098999587 48 2240 An anti-malaria and mitochondrial poison. SGTC_1661 st013063 9.66 µM 2.90265296313975 0.00325764971830441 no 78 0.00185008206224365 14 721395 SGTC_221 trifluoperazine 10.304 µM 2.88371324645044 0.00343576603029147 no 79 0.00196508225378844 47 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_272 doxorubicin 8.13 µM 2.86288410257022 0.00364171218551738 no 80 0.00209902044345995 25 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1371 2421-0008 32.7 µM 2.86021725440315 0.00366886506934854 no 81 0.0021167543786529 48 2827552 SGTC_1171 0368-0077 21.4 µM 2.8528610887308 0.00374470684589935 no 82 0.0021663778382786 36 3239779 SGTC_3062 9077494 49.47 µM 2.85218673569062 0.0037517292637082 no 83 0.00217097927708883 17 16459633 SGTC_3037 9091026 49.47 µM 2.84991708577807 0.003775451245549 no 84 0.00218653137234994 32 25236398 YIL048W NEO1 SGTC_2549 cedrol 20.94 µM 2.84935628024013 0.00378133336765798 no 85 0.00219038965107649 33 6708665 A sedative which affects the nervous system. SGTC_324 1315-0088 19.6 µM 2.84140208345848 0.00386565183141124 no 86 0.00224578212833209 25 6787421 SGTC_558 k064-0027 21.3 µM 2.83423023502082 0.00394311733105071 no 87 0.00229681117473404 32 5088526 SGTC_203 k066-0004 30.888 µM 2.79175987895048 0.0044310159248226 no 88 0.00262111211734223 26 6795412 SGTC_2563 tomatine 8.54 µM 2.79043534320171 0.00444706371086497 no 89 0.00263186061857469 31 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_948 3448-0295 75.3 µM 2.7882048020441 0.00447420581502401 no 90 0.00265005129439439 20 678569 SGTC_2069 5228469 200 µM 2.77371267603586 0.00465418346898298 no 91 0.0027710301017646 17 2835210 SGTC_2000 st075254 36.4 µM 2.77011120057233 0.00469990050896141 no 92 0.00280185787689134 12 17234175 SGTC_764 1951-2361 146 µM 2.7681751075186 0.00472464242139295 no 93 0.00281855794730979 31 5438930 SGTC_329 k048-0121 21.3 µM 2.76440138096341 0.00477320213741485 no 94 0.00285136712741276 24 6832902 SGTC_341 1486-1430 230 µM 2.74079043983949 0.00508725437369319 no 95 0.00306457925875076 55 2054753 YPL210C SRP72 SGTC_294 k038-0071 157 µM 2.72296197737665 0.00533644853284675 no 96 0.0032349751881617 36 24152826 SGTC_2100 5377183 190 µM 2.704596768527 0.00560443752643321 no 97 0.00341936738531613 25 2844202 SGTC_1279 0874-0590 65.2 µM 2.69358250247061 0.00577083362813007 no 98 0.00353443241354801 12 3523074 SGTC_3356 9151811 4.48 µM 2.6869852269163 0.00587258713993235 no 99 0.00360500707593411 17 1859254 YPR165W RHO1 SGTC_3248 9135562 49.47 µM 2.68003022870163 0.00598157818926175 no 100 0.00368077559952376 21 17650701 SGTC_2859 9028643 45.46 µM 2.66865648677803 0.00616368237075563 no 101 0.00380776467549428 11 17151580 SGTC_744 1594-0068 283 µM 2.66414615960731 0.00623724604080002 no 102 0.00385920094780855 24 668392 SGTC_1533 dihydroergotamine mesylate 29.4 µM 2.64086729618669 0.00662942306537526 no 103 0.00413470514171264 36 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_398 bronopol 33.3 µM 2.63858453941697 0.00666902993398586 no 104 0.00416264698719188 33 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_116 0155-0182 31.788 µM 2.62663693398572 0.00687975732282406 no 105 0.00431166441280255 18 771486 SGTC_1712 st032288 53.4 µM 2.62143352895995 0.00697335655669886 no 106 0.00437804178122979 67 2883011 SGTC_1203 3992-3522 103 µM 2.61931954269035 0.00701170308355423 no 107 0.00440526871337499 33 5322312 SGTC_1060 3448-7350 82 µM 2.61127372556478 0.00715935726576617 no 108 0.00451028302055268 35 570178 SGTC_97 0535-0701 19.132 µM 2.60634851352481 0.00725109049112734 no 109 0.00457566470812864 30 2832013 YGL099W LSG1 SGTC_2662 daunorubicin 22.37 µM 2.59538523323837 0.00745901396372079 no 110 0.00472424758572647 38 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2444 5485484 36.41 µM 2.57884064568687 0.00778273561445564 no 111 0.00495662527212375 36 6790631 SGTC_1409 3909-8004 61.9 µM 2.57645221318924 0.00783047609528355 no 112 0.00499100010938708 24 2119279 SGTC_3308 9128332 17.569 µM 2.57024138138349 0.007955827499569 no 113 0.00508138379168806 32 17332805 YDL196W YDL196W SGTC_2139 5578692 56.4705 µM 2.56008907178902 0.00816453007377271 no 114 0.00523226692951175 45 650991 YMR113W FOL3 SGTC_2006 4011487 200 µM 2.55964631510126 0.00817374035832429 no 115 0.00523893693437984 46 45595294 SGTC_2233 sulbentine 40.3845 µM 2.55053162135817 0.00836538433801451 no 116 0.00537793831608238 63 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2676 harmalol 100 µM 2.54429621394751 0.00849875098976498 no 117 0.00547490919577785 32 5459187 A monoamine oxidase inhibitor SGTC_1057 3448-5381 134 µM 2.53204149100829 0.00876630878818995 no 118 0.00567002858955241 45 5497911 SGTC_2374 9071832 200 µM 2.51626814341172 0.00912153927316844 no 119 0.00593024543678339 26 17381698 SGTC_642 0335-0876 158 µM 2.49963517696707 0.0095097201331614 no 120 0.00621606297044909 33 6812350 SGTC_1818 st052136 56.3 µM 2.4900026073912 0.00974106743130148 no 121 0.00638710790732136 51 674169 SGTC_1496 4469-0713 57.4 µM 2.46680973643517 0.0103183677974975 no 122 0.00681613855942701 19 746691 SGTC_887 0885-0007 9.62 µM 2.46498378147942 0.0103650597035032 no 123 0.00685097267197472 47 5719458 SGTC_257 daunorubicin 18.5 µM 2.45787201845173 0.0105486763990942 no 124 0.00698814855640876 41 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_322 k048-0136 19.3 µM 2.45682915418094 0.0105758387042845 no 125 0.00700846645204516 29 6823282 SGTC_42 0133-0086 60.653 µM 2.413252197923 0.0117666505185963 no 126 0.00790543755162962 44 162923 Model of phenazepam hydroxylation. SGTC_127 0180-0333 59.125 µM 2.41213769119784 0.0117985739715862 no 127 0.00792964548623334 15 771601 SGTC_3041 9091929 49.47 µM 2.40875696624041 0.0118958701817169 no 128 0.0080034766595585 24 25236887 SGTC_1417 3966-0327 90.4 µM 2.39659704582404 0.0122516051668147 no 129 0.00827405538292308 26 651118 SGTC_346 4513-0042 7.16 µM 2.39459155812988 0.0123111521014858 no 130 0.00831944433732178 35 2827372 SGTC_1341 1486-1360 280 µM 2.39017809940792 0.0124430801884487 no 131 0.00842010213957133 28 3976547 SGTC_2505 galangin 7.89 µM 2.38584301123178 0.0125738557468103 no 132 0.0085200116791604 39 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1504 k297-0033 30 µM 2.3853259827341 0.0125895319529553 no 133 0.00853199664259752 10 4388117 SGTC_1230 0170-0365 3.77 µM 2.38473836521272 0.0126073689421179 no 134 0.00854563585025646 52 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_889 0919-1524 82.7 µM 2.36083387376827 0.0133517672648224 no 135 0.00911694836048963 22 3905452 SGTC_1916 st067606 49.2 µM 2.3484936561563 0.01375069214212 no 136 0.00942476014595158 46 19590279 SGTC_960 1222-0186 7.7 µM 2.34809282273198 0.0137638205613867 no 137 0.00943490906161016 42 3126296 SGTC_3027 9089541 49.47 µM 2.33864675077991 0.0140763505966708 no 138 0.00967686156836197 41 9943819 SGTC_459 nigericin 15.3 µM 2.33286454069457 0.0142706614008176 no 139 0.0098276279823712 41 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1019 4262-0212 3.4 µM 2.32683941500279 0.0144755889405287 no 140 0.00998690686830447 41 4677213 SGTC_590 k048-0076 22.4 µM 2.32195501065536 0.0146435724377877 no 141 0.0101176791187513 41 6832814 SGTC_293 4049-0273 38.5 µM 2.31970635165605 0.0147214700132439 no 142 0.0101783840043734 32 1380311 SGTC_2991 9074669 71.4286 µM 2.31796979931604 0.014781870982993 no 143 0.0102254812264223 73 17333109 SGTC_217 ketoconazole 989 nM 2.31758134503929 0.0147954113801198 no 144 0.0102360425136132 29 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_514 4466-0038 2.65 nM 2.29767659959617 0.0155036582179643 no 145 0.010790101178735 82 5722064 SGTC_1255 0566-0045 221 µM 2.27583755689091 0.0163140202607806 no 146 0.0114278669836437 49 2788469 SGTC_600 1495-0418 41.6 µM 2.27580379352546 0.016315300650068 no 147 0.0114288777996651 40 5377768 SGTC_2743 auranofin 4.32 µM 2.26310851991649 0.0168028765975393 no 148 0.0118145002415779 29 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_245 methotrexate 289.6 µM 2.23952356905974 0.0177418091257578 no 149 0.0125609347653841 48 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_641 4092-0595 30 µM 2.23627806648963 0.0178744545221774 no 150 0.0126667811332707 50 786260 SGTC_2802 7925815 54.55 µM 2.2267571641385 0.0182684691932783 no 151 0.0129817538344568 45 1262923 SGTC_576 1073-0113 22.7 µM 2.22192609946733 0.0184712132436469 no 152 0.0131441501288144 86 5439563 SGTC_247 mechlorethamine 29.705 µM 2.22109682549919 0.0185062071597766 no 153 0.0131722020065278 17 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2985 9022375 71.43 µM 2.20712250548096 0.0191044435837133 no 154 0.0136527509354887 43 4939335 SGTC_2504 purpurogallin 52.29 µM 2.20168404270613 0.01934166720741 no 155 0.0138438173423129 29 5281571 An antioxidant. SGTC_1478 0453-0656 35.7 µM 2.19638518270778 0.0195752042281403 no 156 0.0140321926559853 47 5258496 SGTC_95 0471-0001 561.058 µM 2.19267655593514 0.0197400756114298 no 157 0.0141653455078384 35 4015405 SGTC_778 3456-2434 196 µM 2.1908502849614 0.019821696859944 no 158 0.0142313141821292 33 5539063 SGTC_1892 st058411 7.36 µM 2.18334998709608 0.0201599166844673 no 159 0.0145050230037241 39 3934738 SGTC_2495 cafestol 54.53 µM 2.17882967913571 0.0203661103113255 no 160 0.014672161642251 57 16667697 An anti-infammatory. SGTC_1039 k821-0043 94 µM 2.17602389052404 0.020494993163818 no 161 0.014776737102217 38 15992768 SGTC_1731 st035964 63 µM 2.17157165031362 0.0207009232528435 no 162 0.0149439936481654 59 6739575 SGTC_774 k060-0086 136 µM 2.168245303515 0.0208559185162391 no 163 0.0150700137837871 45 5911235 SGTC_2965 9082772 38.63 µM 2.1658075027847 0.0209701337299443 no 164 0.0151629498909989 25 16459634 SGTC_2912 7964298 10.93 µM 2.14852195255482 0.0217952716152532 no 165 0.0158361571882768 77 2975850 SGTC_4 0960-0234 25.671 µM 2.14503258920731 0.0219651238219407 no 166 0.0159751207216372 36 6821112 SGTC_152 4469-0003 551.229 µM 2.14171869244106 0.0221274681755958 no 167 0.0161080628075634 77 697280 SGTC_513 4245-1575 41.7 µM 2.13383177591084 0.0225179171430147 no 168 0.0164282768881442 89 719745 SGTC_1663 st014140 55.4 µM 2.13010725562957 0.0227043128948275 no 169 0.0165813797272874 28 4207120 SGTC_2075 5212009 200 µM 2.12443039418219 0.0229909152771935 no 170 0.0168170853513259 31 780898 SGTC_414 piperonyl butoxide 100 µM 2.1220922300729 0.0231098428445892 no 171 0.0169149968795686 38 5794 A potent inhibitor of cytochrome P450. SGTC_1519 esterone 74 µM 2.11818872755876 0.023309543415446 no 172 0.017079543735873 45 698 A steroid. SGTC_340 k038-0059 454 µM 2.11410479276649 0.0235200274420514 no 173 0.0172531589680086 36 23733424 SGTC_234 nsc-17383 10.7 µM 2.11007504501999 0.0237292836176571 no 174 0.0174259461982952 47 408974 SGTC_1310 1188-0297 994 nM 2.10792851852195 0.0238413856861255 no 175 0.0175185864845074 56 1588352 SGTC_1884 5633444 25 µM 2.10316223035547 0.0240918968970881 no 176 0.0177257953244986 59 5724239 SGTC_2370 9071495 200 µM 2.09796026717542 0.0243678268310285 no 177 0.0179543277034106 45 21791103 SGTC_2870 9038528 12.99 µM 2.09581938602557 0.0244821547107734 no 178 0.0180491079879472 46 6463316 SGTC_2256 7954252 200 µM 2.09513074427944 0.0245190253015062 no 179 0.0180796858056121 56 2972920 SGTC_3218 9131285 49.47 µM 2.09450073483098 0.0245527974686837 no 180 0.0181076988381121 51 17156417 SGTC_643 k048-0106 28.4 µM 2.08354023440329 0.0251466193704991 no 181 0.0186010041279658 61 6763920 SGTC_2223 6903751 107.57 µM 2.08232162909258 0.0252133787927046 no 182 0.0186565507850626 43 5598863 SGTC_3224 9130643 49.47 µM 2.0795279559484 0.025366986559116 no 183 0.0187844255136481 51 17644395 SGTC_1726 st035556 14.5795 µM 2.06925269048528 0.0259387234841327 no 184 0.0192611903033915 33 5919439 SGTC_1326 1431-2094 10.8 µM 2.06497129219307 0.0261801110463725 no 185 0.0194628583300691 53 616278 SGTC_1250 0485-0349 40.2 µM 2.06159855885505 0.0263715876986021 no 186 0.0196229856811309 48 6842794 YDL195W SEC31 SGTC_2941 9056145 11.23 µM 2.05539183438827 0.0267270146751328 no 187 0.0199205867815866 48 2119517 SGTC_3180 9109287 49.47 µM 2.05432511289443 0.0267885013618168 no 188 0.0199721178628601 67 18891271 SGTC_138 0850-0259 40.9225 µM 2.05223854283003 0.0269091144570808 no 189 0.0200732427032687 98 6813004 SGTC_63 0099-0242 26.702 µM 2.03872788582987 0.0277011089717132 no 190 0.0207385965193998 71 3898502 YLR359W ADE13 SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.03817296727001 0.0277340492698148 no 191 0.0207663189762272 51 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_492 tmb-8 126 µM 2.03298504528995 0.0280435893152436 no 192 0.0210270169512642 32 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1003 4049-0218 100 µM 2.02880965975242 0.0282948005360113 no 193 0.0212388405158389 73 295161 SGTC_815 1582-0027 36.9 µM 2.02115593320813 0.0287601485722967 no 194 0.0216318128880968 58 3128206 SGTC_934 2950-0684 338 µM 2.02071628841386 0.0287870711932847 no 195 0.0216545713544773 45 1121253 SGTC_2837 9008476 45.46 µM 2.01407463421764 0.0291963431500077 no 196 0.0220008491128522 44 2992805 SGTC_1470 k295-0292 231 µM 2.01062937531739 0.0294105436670266 no 197 0.0221823094338252 52 5045612 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 2.0065942645607 0.0296630741339966 no 198 0.0223964412595014 62 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2948 9070189 9.45 µM 2.00613594359908 0.0296918708224852 no 199 0.0224208729420731 36 6473636 YDL196W YDL196W SGTC_1166 k206-0078 225 µM 2.00312413467791 0.0298816829042294 no 200 0.0225819830382537 54 5404595 SGTC_428 3448-4153 16.5 µM 2.00260093637611 0.0299147586189054 no 201 0.022610069646486 52 3834874 SGTC_1765 st044815 90.4 µM 1.99603653874212 0.0303323353566397 no 202 0.0229649728795839 67 645695 SGTC_354 2783-3500 4.88 µM 1.99071490026211 0.0306743920962902 no 203 0.0232561198276498 90 6740761 SGTC_1023 4482-3888 16 µM 1.97232436498744 0.0318811511380051 no 204 0.024286294963918 53 3303168 SGTC_3345 9148410 3.559 µM 1.97023396342095 0.0320207688623837 no 205 0.0244057813790756 37 4903596 SGTC_1927 st060202 13.8 µM 1.96277268690432 0.0325232298115558 no 206 0.0248362964136828 47 688887 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.96045015765762 0.0326809556554071 no 207 0.0249715991128191 54 689007 SGTC_1300 1094-0077 113 µM 1.95929036323626 0.0327599545571972 no 208 0.0250393958420645 50 5532636 SGTC_3033 9090887 49.47 µM 1.95898292112877 0.0327809222244238 no 209 0.0250573934721589 72 19325384 SGTC_954 1189-0853 2.85 µM 1.95789149248086 0.0328554474443844 no 210 0.0251213731989447 49 2828194 SGTC_497 capsazepine 133 µM 1.93715949673572 0.0342977974929211 no 211 0.0263629248157428 47 2733484 A calcium channel blocker. SGTC_391 gliotoxin 8.33 µM 1.92881135992793 0.034893099232048 no 212 0.0268771425256487 61 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1945 st075991 56.6 µM 1.92836821810538 0.034924935075388 no 213 0.0269046710319876 71 1084980 SGTC_540 1187-0821 17.3 µM 1.92393226445772 0.0352449350828981 no 214 0.0271815371918606 70 847520 SGTC_2519 cryptotanshinone 88.04 µM 1.92350118472755 0.0352761600441639 no 215 0.0272085689264573 81 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1942 st076330 65.2 µM 1.9186704815684 0.0356276229671667 no 216 0.0275130247540901 49 24208414 SGTC_842 0271-0008 11.1 µM 1.91367750436048 0.0359939036087631 no 217 0.027830687572904 66 1221709 SGTC_396 dithiazanine 1.25 µM 1.91140757655599 0.0361614405139081 no 218 0.0279761118994216 38 10578 An antihelmenthic. SGTC_470 aa-861 153 µM 1.90922667644848 0.0363230074536063 no 219 0.0281164282041747 74 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2671 danthron 100 µM 1.90633384930973 0.0365382270605747 no 220 0.0283034526197891 79 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1354 1498-1681 81 µM 1.90571921247832 0.0365840887400441 no 221 0.0283433226339012 68 5754243 SGTC_1917 st066507 28.5 µM 1.89816489007373 0.0371516170985736 no 222 0.0288371821466451 72 3156428 SGTC_2539 epi(13)torulosol 80 µM 1.88909236569168 0.0378426897255889 no 223 0.0294397266164895 57 6708597 SGTC_387 norethindrone acetate 66.7 µM 1.88009028365686 0.0385387297374749 no 224 0.0300478872329605 54 541197 SGTC_2958 9077254 16.72 µM 1.87932937800175 0.038598038003375 no 225 0.030099766352029 58 16457351 SGTC_834 0312-0008 75.7 µM 1.87083629476366 0.0392650866262316 no 226 0.0306838876021309 63 6385573 YIL048W NEO1 SGTC_1188 1403-0014 4.57 µM 1.86675777704968 0.0395887324415438 no 227 0.0309677106319669 63 9614867 SGTC_3050 9093513 49.47 µM 1.86453444082263 0.0397660742787613 no 228 0.0311233448390722 75 25236664 SGTC_2004 4023728 41.89 µM 1.86352656040953 0.0398466791721744 no 229 0.0311941096263202 94 360084 YDR527W RBA50 SGTC_3189 9110682 49.47 µM 1.85837396721599 0.0402608334621201 no 230 0.0315579632481813 61 17122418 SGTC_1336 1486-0901 104 µM 1.85759899638395 0.0403234253413946 no 231 0.0316129905818432 43 5006114 SGTC_1126 isoteolin 1.0172 µM 1.85659161390603 0.0404049064608698 no 232 0.0316846389747274 61 133323 SGTC_2759 disulfiram 3.38 µM 1.85252302970082 0.0407353511593042 no 233 0.0319753768462746 87 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2659 sanguinarine 24.21 µM 1.84790846750755 0.041112790032695 no 234 0.0323077926928633 55 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_878 0828-0289 13.7 µM 1.84745692156499 0.0411498751565673 no 235 0.0323404730088979 79 745350 YLR208W SEC13 SGTC_1050 3232-1156 69.3 µM 1.83678084659663 0.0420346226992985 no 236 0.0331211272777555 87 700529 SGTC_1959 st077091 55.8 µM 1.83599318317736 0.0421005032218261 no 237 0.0331793324231457 97 821356 YKL052C ASK1 SGTC_1718 roemerine 11.9335 µM 1.82691159868134 0.0428661433972756 no 238 0.033856531026009 79 235224 An aporphine alkaloid with mutagenic activity. SGTC_1805 st050013 60.3 µM 1.82615458049742 0.0429304700912449 no 239 0.0339134903405549 53 4037144 SGTC_2430 5571206 200 µM 1.82108537299757 0.0433632322668368 no 240 0.0342969401816146 85 1731771 SGTC_2760 etidronate 98.04 µM 1.81887285696889 0.043553217381819 no 241 0.0344654148782879 55 3305 A chelator and antioxidant. SGTC_2009 4012297 12.05 µM 1.81585063789983 0.0438138153370936 no 242 0.0346966435436602 66 45595307 SGTC_411 enrofloxacin 100 µM 1.81103534780678 0.0442316223598705 no 243 0.035067690085289 50 71188 A bacterial gyrase inhibitor. SGTC_3009 9080819 71.4286 µM 1.81088904449666 0.044244366717071 no 244 0.0350790143910072 65 17027216 SGTC_2819 7996655 46.38 µM 1.80909786074278 0.0444006352761685 no 245 0.0352179006916031 41 6456960 SGTC_2249 haloperidol 116.36 µM 1.80808919426777 0.0444888300983755 no 246 0.0352963098474947 115 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1402 3909-7673 35.9 µM 1.80548755172981 0.0447169616650946 no 247 0.0354992108652662 47 5328014 SGTC_2172 5754775 163.918 µM 1.80271343976898 0.0449612535042038 no 248 0.0357166151864777 90 2263357 SGTC_2157 5649910 96.377 µM 1.79790428860406 0.0453872979865155 no 249 0.0360960882053418 62 2858091 SGTC_2779 methotrexate 400 µM 1.79378424303125 0.0457548714544619 no 250 0.0364238064505284 76 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_389 tpck 16.7 µM 1.79215212541248 0.0459011422864548 no 251 0.0365543005304369 54 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_3068 9116768 49.47 µM 1.78934127599723 0.0461539319428527 no 252 0.0367799352304439 75 41904888 SGTC_2101 5377231 179.231 µM 1.78325539698663 0.0467050879378588 no 253 0.0372723692221585 59 2844213 SGTC_1879 gemcitabine 100 µM 1.78299311847332 0.046728958870424 no 254 0.0372937117646503 59 60750 A nucleoside analog which inhibits DNA replication. SGTC_866 0495-0101 262 µM 1.77317616071256 0.0476294978066113 no 255 0.0380997605004046 76 635694 SGTC_738 1315-0003 72.4 µM 1.7722727727623 0.0477130619815593 no 256 0.0381746443025272 62 6251474 SGTC_479 n-linoleoylglycine 10 µM 1.76797466580072 0.0481122500025217 no 257 0.03853256952234 70 6433346 An anti-infammatory. SGTC_2971 9092186 9.93 µM 1.76648861083747 0.0482508879548324 no 258 0.0386569553243941 72 25236400 SGTC_2947 9072639 7.68 µM 1.76537282855339 0.0483551921235563 no 259 0.0387505634284249 89 16488146 SGTC_218 alverine citrate 93.75 µM 1.75518257858455 0.0493161504031827 no 260 0.0396140414171907 75 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3071 9117417 49.47 µM 1.75511675486377 0.0493224068987107 no 261 0.0396196694871086 69 45595590 YGL055W OLE1 SGTC_1234 0326-0494 15.5 µM 1.7524054575744 0.049580664799236 no 262 0.0398520568385356 83 1547813 SGTC_937 3122-0005 46.7 µM 1.75238416428579 0.0495826973013294 no 263 0.039853886277996 59 759535 SGTC_605 1315-0399 119 µM 1.75161148717707 0.0496564964197082 no 264 0.0399203179929325 84 24020461 SGTC_2431 5490079 200 µM 1.74642138378177 0.0501544822582913 no 265 0.0403688784317241 97 5722345 SGTC_2210 7115885 190.385 µM 1.74167970003378 0.0506129152426428 no 266 0.0407822532806521 63 2927039 SGTC_768 0384-0033 77.3 µM 1.74122756403286 0.0506568021584603 no 267 0.0408218487273563 82 3965305 YMR134W ERG29 SGTC_552 k242-0005 476 µM 1.74116690442652 0.0506626924333232 no 268 0.0408271633157982 73 4088318 SGTC_2785 7756463 72.73 µM 1.74035416059117 0.0507416655313989 no 269 0.0408984246498656 93 2201551 SGTC_2617 dihydrotanshinone i 20.83 µM 1.73909303226282 0.0508644015185742 no 270 0.041009200036022 103 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1667 st014849 34.6 µM 1.73791392439062 0.0509793687733071 no 271 0.0411129908846028 69 5348460 SGTC_549 1661-1316 519 µM 1.73610198959321 0.0511564419744268 no 272 0.041272901327015 84 2857282 SGTC_916 4466-0038 42 nM 1.73424922667941 0.0513380108731331 no 273 0.0414369360005954 103 5722064 YGL116W CDC20 SGTC_2289 7946404 165.07 µM 1.73107143282049 0.0516506247484473 no 274 0.0417195123789856 91 1246120 YPR165W RHO1 SGTC_1005 4092-0690 4.4 µM 1.7272066618943 0.0520328570406992 no 275 0.0420652774203455 90 1529343 SGTC_2666 tannic acid 100 µM 1.72706362301666 0.052047046833754 no 276 0.0420781188936267 85 16134267 A thiamine antagonist. SGTC_1033 k072-0102 21.3 µM 1.72596410896725 0.0521562238763678 no 277 0.0421769349484497 69 5965931 SGTC_908 3448-7491 47.7 µM 1.72418035012609 0.0523337303413641 no 278 0.0423376451504447 75 1203031 SGTC_2777 climbazole 1.536 µM 1.72386749698408 0.0523649125542744 no 279 0.0423658830806217 81 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_630 4356-0227 183 µM 1.7209735811007 0.0526540502504885 no 280 0.0426278090062886 100 779312 SGTC_1733 st037357 54.9 µM 1.71983869878099 0.0527677841678629 no 281 0.0427308830056075 83 1272339 YGL099W LSG1 SGTC_2016 5121758 140 µM 1.71945641255738 0.052806139405561 no 282 0.0427656489127003 99 2795203 SGTC_2412 st077135 33.4 µM 1.71719678211279 0.0530333027834593 no 283 0.0429716116557526 74 13258915 SGTC_1119 parthenolide 318.541 nM 1.70698160096716 0.054069932821568 no 284 0.0439127361249199 81 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2387 9077560 195.08 µM 1.69882701972402 0.0549089123144169 no 285 0.0446758905095167 78 5303272 SGTC_3154 9100113 49.47 µM 1.69581517031322 0.0552213739834021 no 286 0.0449604443037666 87 25237525 SGTC_1106 tegaserod maleate 11.7 µM 1.69445210976048 0.0553632443461288 no 287 0.0450897023080064 84 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2208 7283366 200 µM 1.69175593183753 0.0556447161111401 no 288 0.045346259570315 64 898663 SGTC_1479 0549-0158 134 µM 1.68671199485413 0.0561743176716337 no 289 0.0458293722625912 75 5440202 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.6862334520089 0.056224769279926 no 290 0.0458754215417237 89 4330530 SGTC_1435 4092-0789 56.7 µM 1.67419925899293 0.0575052885779888 no 291 0.0470457225445576 91 2248285 SGTC_682 0kpi-0099 17 µM 1.67238265614485 0.0577005646959707 no 292 0.0472244449632802 129 1714895 YML126C ERG13 SGTC_2257 7960413 200 µM 1.66944125840697 0.0580178561247545 no 293 0.0475149813711393 89 2974689 YIL048W NEO1 SGTC_310 1273-0058 1.06 µM 1.66458151881414 0.0585450833198188 no 294 0.0479981375080285 55 2734232 SGTC_1317 1273-0028 910 nM 1.66240600009984 0.0587823182797974 no 295 0.0482156983350383 95 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_151 3013-0144 2.285 µM 1.65856333325497 0.059203194138603 no 296 0.0486019077619777 105 906558 YHR107C CDC12 SGTC_1752 st044819 83.042 µM 1.6585257692915 0.0592073200407151 no 297 0.0486056953205114 82 441209 YML126C ERG13 SGTC_2541 muurolladie-3-one 83.07 µM 1.65384998157536 0.0597226564131744 no 298 0.0490789988235292 122 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_438 sphingosine 6.67 µM 1.64672054043645 0.0605151757446646 no 299 0.049807750125439 55 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2046 4110841 106 µM 1.64534921361455 0.0606685537921903 no 300 0.0499489081812585 94 44119630 YMR134W ERG29 SGTC_1855 st056195 39.6 µM 1.64357143908183 0.0608678439826987 no 301 0.0501323787758683 73 4028379 SGTC_2423 st077119 87.2 µM 1.63963532352124 0.0613109072951581 no 302 0.0505405069787501 74 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1129 3453-1384 223 µM 1.6381232061172 0.0614817850762852 no 303 0.0506979974894589 80 1084452 SGTC_1325 1431-0015 227 µM 1.63374298901101 0.0619788740481114 no 304 0.0511564138369225 76 1103340 SGTC_1898 st060199 18.6 µM 1.63266340587306 0.0621018710126195 no 305 0.0512699039209753 72 688866 SGTC_746 1095-0025 46.6 µM 1.62987972574945 0.0624198944329821 no 306 0.0515634596970972 78 6749286 SGTC_553 k007-0256 45.7 µM 1.62840400774789 0.0625890031205393 no 307 0.0517196241968004 93 6287000 SGTC_131 0141-0277 33.849 µM 1.62631707136532 0.0628287632581403 no 308 0.0519411110040926 97 1547771 SGTC_2928 9011484 9.79 µM 1.624433329065 0.0630457931654235 no 309 0.0521416793570843 114 2994751 SGTC_3162 9099653 49.47 µM 1.6237046404289 0.0631299033716422 no 310 0.052219430091681 63 25237511 SGTC_710 3448-4187 58 µM 1.62283717015733 0.0632301466070928 no 311 0.0523121087797735 87 3946412 SGTC_1162 k048-0130 20.1 µM 1.6202886922868 0.0635253608957393 no 312 0.0525851383988837 82 6797406 SGTC_3311 9131146 2.8755 µM 1.61963001381892 0.0636018360246337 no 313 0.0526558891285435 113 4900406 YPR165W RHO1 SGTC_1000 4048-0884 8.67 µM 1.61949270847481 0.0636177867277975 no 314 0.0526706470384171 84 13040088 SGTC_951 1171-0579 82.7 µM 1.61575131474233 0.0640536218783233 no 315 0.053074045737345 105 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_306 1672-3436 11.6 µM 1.61487953668419 0.0641555080664684 no 316 0.0531683922610555 76 6797378 SGTC_2896 9052656 71.43 µM 1.61089883406591 0.0646223413161786 no 317 0.0536008870951142 118 6469436 SGTC_1174 0739-0097 51.1 µM 1.60998084712615 0.0647303708636372 no 318 0.0537010188078151 81 728447 SGTC_1089 terbinafine 2.25 µM 1.60922317198504 0.0648196403713018 no 319 0.0537837756677477 73 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1810 st050138 53 µM 1.60782964088738 0.0649840761590712 no 320 0.0539362473910715 99 3444541 SGTC_287 k060-0039 29.6 µM 1.60228023141653 0.0656421168182954 no 321 0.0545468275679061 91 5861974 SGTC_3087 9117406 49.47 µM 1.59983486013707 0.0659337200751671 no 322 0.054817611571076 80 42546093 SGTC_2467 5474540 200 µM 1.59878314192615 0.066059442629435 no 323 0.0549343980610039 91 5413519 SGTC_649 1123-0311 367 µM 1.59825273299923 0.0661229182061588 no 324 0.0549933710753968 92 693629 YIL048W NEO1 SGTC_1684 st024538 14.6195 µM 1.59783570634239 0.0661728581671097 no 325 0.055039772908225 75 6732859 SGTC_424 splitomicin 100 mM 1.59765330392517 0.0661947104839338 no 326 0.0550600782307899 75 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_423 5-fluorouracil 457 µM 1.59558604898495 0.0664427641881918 no 327 0.0552906221625008 118 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2455 5377712 9.75 µM 1.59533426103628 0.0664730257855442 no 328 0.0553187540066234 71 2243908 SGTC_1351 1496-0003 46.5 µM 1.59185413708834 0.0668923846403663 no 329 0.0557087413155651 79 3891978 SGTC_2415 st077333 57.7 µM 1.59047780963758 0.067058797302103 no 330 0.0558635718160683 125 2766255 SGTC_1766 st045414 44.774 µM 1.58729673184886 0.0674446486021101 no 331 0.0562227275435303 98 253960 SGTC_1347 1493-0251 600 nM 1.58432134872713 0.0678071009245237 no 332 0.0565603049915252 81 3986378 SGTC_135 0933-0004 26.348 µM 1.58364154036251 0.067890123909627 no 333 0.0566376575636271 92 21230617 YGL099W LSG1 SGTC_2021 4019055 173 µM 1.57975135682898 0.0683667312840892 no 334 0.0570819096672988 140 44827708 YER133W GLC7 SGTC_3080 9117754 49.47 µM 1.57674157456651 0.0687372441410527 no 335 0.0574275000101339 88 9550191 SGTC_2925 9010536 32.5 µM 1.57510505930734 0.0689393526810702 no 336 0.0576160982240776 68 2994177 SGTC_978 1416-0512 87.4 µM 1.57078813013802 0.0694746884499129 no 337 0.0581159350537887 85 6814003 SGTC_2703 st077852 53.4 µM 1.56747756076307 0.0698873915843882 no 338 0.0585015536010638 92 6281836 SGTC_194 1486-1323 56.904 µM 1.56579286226845 0.0700981329831317 no 339 0.058698558892337 108 5178754 SGTC_646 4092-0839 27.3 µM 1.56558867849744 0.0701237078090046 no 340 0.0587224710759038 104 877796 SGTC_405 ebelactone b 50 µM 1.56556104103244 0.0701271700623796 no 341 0.0587257083169108 56 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1665 st014639 11.4 µM 1.56335488199898 0.0704039686503134 no 342 0.0589845730585447 97 981133 YIL048W NEO1 SGTC_1214 0358-0031 63.7 µM 1.56032847869412 0.070785045814096 no 343 0.0593411383840034 92 4301366 SGTC_2426 5582046 32.21 µM 1.55832920952461 0.0710376567887895 no 344 0.059577614085528 84 2251934 SGTC_2973 9094665 17.96 µM 1.55422068984943 0.0715589476912595 no 345 0.0600658919673088 117 25237061 YIL048W NEO1 SGTC_1875 nocodazole 6 µM 1.55190673406704 0.071853832816401 no 346 0.0603422706969523 89 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1485 3909-9022 254 µM 1.54198430480123 0.0731288993610988 no 347 0.0615387038263811 79 714516 SGTC_747 3448-8087 38.7 µM 1.54144922231844 0.0731981481928485 no 348 0.0616037460792054 91 5168703 SGTC_1773 st048542 73.5835 µM 1.53327304047505 0.0742625364353383 no 349 0.0626042971457848 147 3237138 SGTC_1387 3342-1166 1.8 µM 1.53137769200154 0.0745109552429989 no 350 0.0628380370896173 64 3418228 SGTC_1980 st071811 45.7 µM 1.52425781114064 0.0754498106337399 no 351 0.0637221608163149 100 4974850 SGTC_2619 obliquin 87.91 µM 1.51780069601279 0.0763090424640481 no 352 0.064532324799873 109 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3082 9117008 49.47 µM 1.51761939893767 0.0763332742261223 no 353 0.0645551868093764 89 41448529 SGTC_36 0335-0881 14.2 µM 1.51639455620181 0.0764971373993032 no 354 0.0647098073822602 134 23828853 SGTC_2725 haloperidol 53.21 µM 1.50646589431535 0.0778353142543584 no 355 0.0659738080118945 114 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3282 9108498 15.4605 µM 1.49539859759985 0.0793478119965717 no 356 0.0674052231682055 108 16459645 SGTC_26 0302-0163 425.158 µM 1.4939626765666 0.079545669734096 no 357 0.0675926874306041 122 3100915 SGTC_1558 st069300 45.6 µM 1.49011685324802 0.0800774303404361 no 358 0.0680967567910338 99 24208000 SGTC_1964 st076914 61 µM 1.48753910399801 0.080435356270549 no 359 0.0684362416480145 120 24208661 SGTC_1768 st044301 37.178 µM 1.48660397639664 0.0805654990593309 no 360 0.0685597184894977 116 3931349 SGTC_2987 9018338 71.43 µM 1.48624865138179 0.0806149917307901 no 361 0.0686066816175962 120 5055682 SGTC_1503 4585-0012 61.3 µM 1.48114880264069 0.0813278739950452 no 362 0.0692834627783157 83 2922052 SGTC_156 3474-0145 5.642 µM 1.47998436321056 0.0814913100073307 no 363 0.0694387098572268 90 2265471 SGTC_1340 1486-1359 257 µM 1.47531102554575 0.0821497332263991 no 364 0.0700644717827819 105 4309068 SGTC_2399 5884133 200 µM 1.47064950538753 0.0828104756591551 no 365 0.0706929642123564 104 722445 SGTC_1399 3562-5772 25 µM 1.46962521398545 0.0829561971873404 no 366 0.0708316437694175 95 23847490 SGTC_363 0455-0021 3.06 µM 1.46672889424076 0.0833692879078421 no 367 0.0712249097176508 118 4597466 SGTC_3281 9140613 49.47 µM 1.46507975588687 0.0836051878669774 no 368 0.0714495795859204 87 16013766 SGTC_1487 3970-0795 2.82 µM 1.46153979292681 0.0841132528652676 no 369 0.0719336816969049 109 3765103 SGTC_789 1309-1135 70.6 µM 1.45524312457242 0.0850226902153944 no 370 0.0728009830040433 81 3092424 SGTC_1686 st019653 115.5 µM 1.44329377060482 0.086768785703625 no 371 0.0744688669294335 111 97252 SGTC_1835 st008666 49.2 µM 1.44116777786389 0.0870822337452949 no 372 0.0747686445729571 78 690455 SGTC_1263 0774-1208 64.8 µM 1.43883608040431 0.0874269815994248 no 373 0.0750984855784401 121 906585 SGTC_2391 6285546 200 µM 1.43714369912222 0.0876778421113663 no 374 0.0753385832946855 86 846083 SGTC_3245 9134821 49.47 µM 1.4323882347342 0.0883856155549664 no 375 0.0760163718727953 123 17014901 SGTC_110 0850-0284 111.64 µM 1.43128542185755 0.0885503577681349 no 376 0.0761742151341622 73 3906265 SGTC_830 4076-0286 57.8 µM 1.42607219774899 0.0893322256415166 no 377 0.0769237515094785 109 6866659 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.42435972355585 0.0895901761089078 no 378 0.0771711835166771 98 4213774 SGTC_1654 st012436 41.8 µM 1.42356358126257 0.0897102876783083 no 379 0.0772864222628993 73 4323132 SGTC_2384 9036245 200 µM 1.42309959267324 0.0897803434216793 no 380 0.0773536432181315 81 6462766 SGTC_1715 st032160 10.2275 µM 1.42123865335252 0.0900617277166681 no 381 0.0776236955487958 96 5289825 SGTC_1583 clindamycin 39.6 µM 1.41938099213597 0.0903432693313416 no 382 0.0778939854745075 113 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_982 1491-0518 27.5 µM 1.41363922353189 0.0912176065307223 no 383 0.0787339292600447 93 3091256 SGTC_2015 5119600 184 µM 1.41238319179105 0.0914097044553483 no 384 0.0789185814154022 127 2828786 SGTC_1067 clotrimazole 1.36 µM 1.41008895228196 0.0917613600643695 no 385 0.0792567094951086 119 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3246 9135460 32.98 µM 1.410057008964 0.0917662633246466 no 386 0.0792614250735039 103 41446951 SGTC_3203 9113543 49.47 µM 1.40973063907433 0.0918163718265584 no 387 0.0793096170499161 123 17018012 SGTC_1466 k213-0079 57.5 µM 1.40669694702382 0.0922831133380653 no 388 0.0797586357142539 137 3657981 SGTC_3077 9117319 49.47 µM 1.4047483798024 0.0925838303444592 no 389 0.0800480569358783 116 17154678 SGTC_2765 myclobutanil 7.74 µM 1.40314594612505 0.0928316722015658 no 390 0.0802866612411629 120 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3073 9114972 49.47 µM 1.40274012374284 0.0928945168697589 no 391 0.0803471738936645 87 41905075 SGTC_1968 st069590 43.6 µM 1.40081942152565 0.0931923789154679 no 392 0.0806340396865891 123 6384066 SGTC_655 k060-0012 42 µM 1.39873085830738 0.0935170731405552 no 393 0.0809468534702723 123 5994525 SGTC_2580 diallyl disulphide 81.36 µM 1.39817667235762 0.0936033686234304 no 394 0.0810300100465593 115 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.39809104131945 0.0936167079683232 no 395 0.0810428648832804 131 5393153 SGTC_939 1165-0479 45.3 µM 1.39778999751287 0.0936636148065856 no 396 0.0810880694634756 101 1377347 SGTC_1082 camptothecin 424.86 nM 1.3974179944336 0.0937216020607127 no 397 0.0811439555326516 134 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_663 1486-0733 13.9 µM 1.3969780911021 0.0937902076962734 no 398 0.0812100797656432 114 722445 YPR165W RHO1 SGTC_1077 5-fluorocytosine 377 nM 1.39599810751196 0.0939431754467812 no 399 0.0813575325215943 137 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1574 spiramycin 23.7 µM 1.39210509479208 0.0945526628106042 no 400 0.0819452878447177 119 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3283 9109332 35.8195 µM 1.39077576934383 0.0947614473017141 no 401 0.0821467164915208 88 17027281 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.38761520270137 0.0952592112012689 no 402 0.0826271248131587 128 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2526 patulin 37.61 µM 1.38589404762525 0.0955310876704125 no 403 0.0828896293291937 138 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3126 9127922 49.47 µM 1.3857290421068 0.0955571821795053 no 404 0.0829148283104502 161 45595682 SGTC_1291 0993-0025 5.79 µM 1.38502881323104 0.0956679770134695 no 405 0.0830218285791782 107 4353356 SGTC_1638 st008370 60.6 µM 1.38496237381582 0.0956784944037951 no 406 0.0830319864164553 118 24207134 SGTC_3181 9108277 49.47 µM 1.38298815387532 0.0959914026671913 no 407 0.0833342491090965 117 17097298 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.3806990712676 0.0963551571310135 no 408 0.0836857534950044 104 75037 A free radical scavenger. SGTC_2630 antimycin a 100 µM 1.38048175088465 0.0963897437466766 no 409 0.0837191823420368 130 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1943 st076331 65.2 µM 1.37945340687145 0.0965535287872794 no 410 0.0838775012305063 99 24208415 SGTC_2670 beta-carotene 100 µM 1.37912030938912 0.0966066252605907 no 411 0.0839288314955122 64 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1999 st074831 12.5 µM 1.37877147496765 0.0966622532259716 no 412 0.0839826121035691 127 17112523 SGTC_1453 4237-0541 195 µM 1.37832642082955 0.096733259319717 no 413 0.0840512646899762 121 739892 SGTC_2625 euphol 100 µM 1.37747928999206 0.0968685205156199 no 414 0.0841820567205143 134 6708538 A triterpene alcohol. SGTC_2473 5854593 8.94 µM 1.37535702738218 0.0972079913645399 no 415 0.0845103923113888 123 2872951 SGTC_1160 4092-0570 10.5 µM 1.37399355884438 0.0974265478616232 no 416 0.0847218410465992 123 4994975 SGTC_794 k038-0031 316 µM 1.36877121516724 0.0982669951125561 no 417 0.085535400658515 109 6624242 SGTC_1679 SEC14.276 6.7 µM 1.36346805064886 0.0991258709117965 no 418 0.0863675234838309 146 1005053 YMR079W SEC14 SGTC_3138 9097216 49.47 µM 1.36226973465308 0.0993207027481123 no 419 0.0865563876807826 119 25237486 SGTC_1721 st082152 9.2685 µM 1.36077053946996 0.0995648479887327 no 420 0.0867931073719475 111 5296051 SGTC_256 clotrimazole 625 nM 1.35544016503723 0.10043645573617 no 421 0.0876386800787723 118 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3252 9135871 49.47 µM 1.35517735717605 0.100479572900944 no 422 0.0876805284865203 108 17682838 SGTC_1749 st037932 54.2 µM 1.35295738827728 0.100844327632654 no 423 0.0880346219424929 128 594497 SGTC_1381 2324-0066 62.1 µM 1.35265421614639 0.100894215537989 no 424 0.0880830616768004 131 10885928 SGTC_2981 9013952 38.96 µM 1.34805753308755 0.101652819666026 no 425 0.0888199393845487 104 2996344 SGTC_105 0111-0055 734.78 µM 1.34612706195915 0.101972646312456 no 426 0.0891307712450045 106 5179370 SGTC_2737 bleomycin 30.5 nM 1.34547106966229 0.102081492943718 no 427 0.0892365789100085 128 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_770 0389-1121 67.2 µM 1.34509757249062 0.102143503847701 no 428 0.0892968635262781 114 6753108 SGTC_1411 3909-8223 150 µM 1.34459800442978 0.102226488855489 no 429 0.0893775440766634 129 X1411 SGTC_2678 equilin 100 µM 1.34319905537297 0.102459134130629 no 430 0.0896037637341856 100 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1097 itavastatin 7.23 µM 1.33520754729001 0.103795505551408 no 431 0.0909042136911503 135 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1158 4092-0494 91.8 µM 1.33386937571701 0.104020510138331 no 432 0.0911233347891424 98 1148199 SGTC_595 3909-8003 73.7 µM 1.33383421192252 0.104026427460111 no 433 0.0911290980195413 118 699517 SGTC_154 3389-1638 511.116 µM 1.33291737571993 0.104180797728974 no 434 0.0912794598847298 116 5238686 SGTC_232 clozapine 119 µM 1.33272094694912 0.104213892578088 no 435 0.0913116982717413 117 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_298 1391-0729 10 µM 1.33155396639706 0.104410665740192 no 436 0.0915034001362636 110 3237558 SGTC_1433 4060-0023 7.6 µM 1.33019275303847 0.10464052992211 no 437 0.0917273856396967 131 3840627 SGTC_1198 1612-1005 86.7 µM 1.32779850846894 0.105045728063791 no 438 0.0921223399139436 143 6998509 SGTC_867 0518-0118 155 µM 1.32748258770803 0.105099278688591 no 439 0.0921745480414973 133 6848158 SGTC_671 0560-0003 407 µM 1.32479104241194 0.105556314500117 no 440 0.0926202333144219 94 3238678 SGTC_911 3456-4043 236 µM 1.32335322290514 0.105801050504214 no 441 0.092858969959035 118 914281 SGTC_2647 atorvastatin 60.16 µM 1.32111197339039 0.106183358535163 no 442 0.0932320156507442 100 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1289 0976-0073 69.1 µM 1.31471841223494 0.107279441258058 no 443 0.0943022781113275 121 3391136 SGTC_1966 st070145 16.1 µM 1.31455976875989 0.107306741695652 no 444 0.0943289492728168 140 3748532 SGTC_1787 fluconazole 80 µM 1.31225367957108 0.107704154750626 no 445 0.0947172776803691 118 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1797 st048695 56.8 µM 1.31122980833976 0.107880940058049 no 446 0.094890067224128 134 592262 YIL048W NEO1 SGTC_177 1327-0068 8.361 µM 1.31101507246374 0.10791804362688 no 447 0.0949263357108776 135 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_895 0964-0006 13.7 µM 1.30937378248086 0.10820194079459 no 448 0.0952038839117395 157 6738897 SGTC_3145 9085516 49.47 µM 1.30843651532812 0.10836430268791 no 449 0.0953626470674672 119 25236195 SGTC_1472 k841-0093 193 µM 1.30401228724934 0.109133074507393 no 450 0.0961146964922704 118 X1472 SGTC_2125 5246583 200 µM 1.30392676176105 0.109147974278814 no 451 0.0961292773221899 142 835267 SGTC_1625 st003711 30.1 µM 1.30151918107286 0.109568009429336 no 452 0.0965404016721893 120 24207034 YER133W GLC7 SGTC_2001 4023502 57.655 µM 1.29766752877923 0.110242394075685 no 453 0.097200803150773 108 108941 YCR052W RSC6 SGTC_2177 5811945 192 µM 1.29409041548143 0.110871371298868 no 454 0.0978170958960555 123 5343475 SGTC_3214 9129694 49.47 µM 1.29337109651407 0.110998161701164 no 455 0.097941370881211 141 17158655 SGTC_2471 5466956 24.79 µM 1.29161116014469 0.111308813817173 no 456 0.0982459186127069 149 724419 SGTC_974 1326-0144 138 µM 1.28807477136752 0.111934914043805 no 457 0.0988599682334899 126 5411856 SGTC_2326 6164455 177.58 µM 1.28418390739319 0.112626677376803 no 458 0.0995388072795702 143 2888790 SGTC_1978 st071761 42 µM 1.28152024854243 0.113102011043929 no 459 0.100005496191933 139 5147680 SGTC_1708 st033234 31.827 µM 1.27944513717081 0.113473308336568 no 460 0.100370173809043 127 674664 SGTC_2019 4016004 108 µM 1.27936670529757 0.113487359089064 no 461 0.100383976341718 144 45595336 SGTC_2698 st077697 67.5 µM 1.27836553073085 0.113666824462932 no 462 0.100560285912682 123 3154499 SGTC_1073 triclabendazole 3.09 µM 1.27818891552863 0.113698504571591 no 463 0.100591411757753 129 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1301 naphtanilide LB 4.81 µM 1.27810343263274 0.113713840208478 no 464 0.10060647939106 146 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2741 miltefosine 3.04 µM 1.27500262792319 0.114271121843325 no 465 0.101154155921628 90 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1343 1487-0095 224 µM 1.27180392539382 0.114848032867637 no 466 0.101721396960629 141 4560101 YGL055W OLE1 SGTC_352 k048-0007 5.11 µM 1.26925730035202 0.115308815773108 no 467 0.102174655124884 164 6811911 SGTC_2521 angolensin 13.4 µM 1.26916939749344 0.115324744225661 no 468 0.102190326605347 103 821428 A flavenoid. SGTC_120 rhodamine 6G 52.259 µM 1.26885378781342 0.115381947219553 no 469 0.102246608478728 184 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_511 blebbistatin 171 µM 1.26709256401061 0.115701532246206 no 470 0.102561097053367 126 3476986 A myosin inhibitor. SGTC_2029 5175081 200 µM 1.26678102160789 0.115758128937468 no 471 0.102616799969733 118 1380876 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.26158765354371 0.116704484795924 no 472 0.103548600564457 102 4000243 SGTC_3030 9087619 49.47 µM 1.26064802828407 0.1168762913504 no 473 0.103717843220557 145 25236973 SGTC_2361 9034121 116 µM 1.25997785687202 0.116998938874397 no 474 0.103838675158768 158 6496917 SGTC_694 1315-0438 43.2 µM 1.25484522018783 0.117941283177831 no 475 0.104767476612605 117 6793154 SGTC_3334 9142812 21.919 µM 1.25417447533819 0.118064826495761 no 476 0.104889297619311 129 45283678 SGTC_1459 k035-0031 35.7 µM 1.25003086678723 0.118830059914139 no 477 0.105644135985161 121 3877128 YMR208W ERG12 SGTC_565 1418-0001 44.5 µM 1.24970930282927 0.118889591857715 no 478 0.105702878886343 138 2862145 SGTC_512 prima-1 270 µM 1.24574764639466 0.119624751955994 no 479 0.106428527697142 115 322968 A re-activator of the apoptotic function of mutant p53. SGTC_528 3492-0019 172 µM 1.2441886806231 0.119914924780241 no 480 0.106715064381716 154 2869262 SGTC_3320 9137005 35.139 µM 1.24045704287703 0.120611514935091 no 481 0.107403196757396 154 4908713 SGTC_1115 galangin 695.678 nM 1.23661586030889 0.121331524643479 no 482 0.108114864452946 145 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2293 7624732 200 µM 1.23583068642122 0.121479072680621 no 483 0.108260752962349 126 894453 SGTC_338 4055-0136 114 µM 1.23563302194009 0.121516237192392 no 484 0.108297502142388 117 2900563 SGTC_416 estradiol valerate 100 µM 1.23557650022945 0.121526865769624 no 485 0.10830801213758 146 13791 A steroid. SGTC_2850 9015429 58.44 µM 1.23493624752989 0.121647307172989 no 486 0.108427115923389 139 6457570 SGTC_137 0438-0332 85.389 µM 1.22990564237792 0.122596560867337 no 487 0.109366220539754 173 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_669 0108-0021 26.2 µM 1.22848892920481 0.122864823917446 no 488 0.109631741378585 132 17201 SGTC_332 4112-0506 40.9 µM 1.22824983501278 0.122910138387466 no 489 0.109676598097317 165 2790355 SGTC_722 3534-0461 190 µM 1.22486351618339 0.123553191024188 no 490 0.110313324330468 118 658262 SGTC_2144 5628481 200 µM 1.2211738880998 0.124256519415691 no 491 0.11101009429289 110 2818399 SGTC_924 2046-0044 21.3 µM 1.21665591655337 0.125121557091326 no 492 0.111867579141439 145 3623589 SGTC_3238 9133470 49.47 µM 1.21404103983845 0.125624134055043 no 493 0.112366026443616 114 3534688 SGTC_1480 1070-0044 41.2 µM 1.21309858704841 0.125805617483965 no 494 0.112546065078511 137 3124987 SGTC_1552 6-methylflavone 10.6 µM 1.21105342863448 0.126200072213254 no 495 0.112937464256064 132 689013 SGTC_383 2324-0395 7.37 µM 1.20826867326011 0.126738559628685 no 496 0.113471967072132 121 3146421 SGTC_3164 9100705 49.47 µM 1.19978951983176 0.1283880155019 no 497 0.115110547697052 98 17174235 SGTC_2010 4012422 159 µM 1.19975432158298 0.128394893560575 no 498 0.115117384576911 139 952393 SGTC_121 0557-0495 61.343 µM 1.19738366653994 0.128858730074226 no 499 0.115578523494683 167 3104427 SGTC_922 1866-0035 480 µM 1.19033137289519 0.130245431050303 no 500 0.116958087295756 163 3156169 SGTC_3186 9110464 49.47 µM 1.18635055458817 0.131032727032937 no 501 0.117741944838226 122 17018021 SGTC_2060 5238662 140 µM 1.18619232404762 0.131064088463213 no 502 0.11777317844297 137 790130 SGTC_2974 9094440 9.66 µM 1.1793314622589 0.132428906259313 no 503 0.119133107399156 144 25236134 SGTC_2124 5246320 200 µM 1.17445641318846 0.133404622334571 no 504 0.120106130308439 164 579342 SGTC_258 haloperidol 50.781 µM 1.17411820376617 0.133472496178592 no 505 0.120173841496345 169 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_72 0744-0168 198.391 µM 1.17410498769252 0.13347514893963 no 506 0.120176487965183 149 677577 SGTC_2113 5491891 107.031 µM 1.17349460228032 0.13359770643329 no 507 0.120298760087816 149 789979 SGTC_2923 7992654 58.14 µM 1.16995031387185 0.134310882753338 no 508 0.121010482233481 140 2985126 SGTC_2050 5263056 171 µM 1.16786800743482 0.134731098373719 no 509 0.121430005355474 156 763468 YGL055W OLE1 SGTC_2831 7999036 19.48 µM 1.16708067690711 0.134890218807143 no 510 0.121588895246173 152 2988270 SGTC_1299 1079-1439 3.74 µM 1.16493224118318 0.135325075883024 no 511 0.122023210773192 156 323161 SGTC_2277 7947813 106.88 µM 1.16400000699713 0.135514064636058 no 512 0.122212004468247 140 1246798 SGTC_2320 7373003 200 µM 1.1633960919386 0.135636590820642 no 513 0.122334417208718 148 5415828 SGTC_1722 st034304 3.6505 µM 1.16021071519367 0.13628411629153 no 514 0.1229815127092 146 4036148 YLR033W RSC58 SGTC_2649 anisomycin 9.56 µM 1.1601167764721 0.136303244270691 no 515 0.12300063231289 148 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1515 3460-0031 42.1 µM 1.15957843070089 0.136412898675653 no 516 0.123110243483432 155 2876596 SGTC_1463 k081-0032 34.1 µM 1.15916736315484 0.136496668694209 no 517 0.123193985953646 139 977755 SGTC_837 0091-0265 12.5 µM 1.15904326168777 0.1365219658116 no 518 0.123219275684499 164 759367 SGTC_64 000l-0018 272.079 µM 1.15799878755753 0.136735000785022 no 519 0.123432265598651 181 6811119 SGTC_2781 5567276 71.43 µM 1.15706329183383 0.136926000942972 no 520 0.12362325138339 161 2853274 SGTC_869 0564-0080 44.1 µM 1.15574298579302 0.137195877959496 no 521 0.123893149952745 126 6843321 SGTC_2298 7976326 193.81 µM 1.15233847936359 0.137893451272262 no 522 0.124591005322229 98 2235818 SGTC_390 dec-rvkr-cmk 16.7 µM 1.15186147056725 0.137991381880861 no 523 0.124689001573483 140 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_3103 9120822 49.47 µM 1.15023461081094 0.138325735311859 no 524 0.125023627279735 185 17141819 SGTC_696 1560-0013 611 µM 1.14915671030886 0.138547570138631 no 525 0.1252456837844 172 1650269 SGTC_1896 st058441 89 µM 1.1465430318242 0.139086478270693 no 526 0.125785266333351 146 688759 SGTC_1424 4048-1941 275 µM 1.14573406338239 0.139253566314645 no 527 0.125952602472317 148 X1424 SGTC_2640 pentamidine 10.38 µM 1.14557304684833 0.139286839698395 no 528 0.125985927459742 157 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1159 4092-0538 61.2 µM 1.14513768253982 0.13937683297199 no 529 0.126076063959466 157 717301 SGTC_2196 6573537 42.6665 µM 1.14388425819548 0.13963614661919 no 530 0.126335820125146 163 2903087 SGTC_1164 k060-0068 93.7 µM 1.14290956328139 0.139838022167873 no 531 0.126538070770059 147 5963676 SGTC_1447 4239-0816 81.9 µM 1.14229174100088 0.139966086128042 no 532 0.126666386541538 162 1341554 SGTC_1987 st072290 61.9 µM 1.14137785364136 0.140155665399197 no 533 0.126856358305426 152 54697379 SGTC_3100 9120536 49.47 µM 1.13892348577814 0.140665669110977 no 534 0.12736753447473 148 16421196 SGTC_673 1082-0474 110 µM 1.13793248375644 0.140871950206839 no 535 0.127574337943293 185 3098046 SGTC_2733 amorolfine 100 µM 1.13707343022051 0.14105093166385 no 536 0.127753795052033 172 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1305 1181-0477 144 µM 1.13574325883299 0.141328373394345 no 537 0.12803201517267 168 6252086 SGTC_3291 9121177 71.43 µM 1.13489571400957 0.141505343648453 no 538 0.128209507970799 141 17015612 SGTC_2475 5812728 15.03 µM 1.1329727590999 0.141907419828881 no 539 0.128612846560366 151 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1117 retinoic acid 1.10837 µM 1.1326132839003 0.141982669269631 no 540 0.128688343841376 149 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1195 1502-0147 41.1 µM 1.13112049169379 0.14229544650855 no 541 0.129002190267163 142 817940 SGTC_107 0358-0022 2.6945 µM 1.13041708962929 0.142442988272201 no 542 0.129150258188823 142 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2158 5657123 3.6195 µM 1.12973440527173 0.142586283321513 no 543 0.129294077609024 158 2858827 SGTC_2799 7812892 81.82 µM 1.12953180814329 0.142628827091235 no 544 0.129336779594078 188 20205235 SGTC_2070 5230947 200 µM 1.12649364389643 0.143267846673935 no 545 0.12997831473533 173 2835538 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.12502348138664 0.143577760314378 no 546 0.130289542045082 151 15053 SGTC_2057 5236571 38.335 µM 1.12422296817936 0.143746700475794 no 547 0.130459223995708 143 54684039 YBR257W POP4 SGTC_580 1123-0028 41 µM 1.11946557195219 0.144753467040748 no 548 0.131470785251286 164 1677248 YPR107C YTH1 SGTC_1210 3013-0140 750 nM 1.11650237637611 0.145382936887708 no 549 0.132103576778164 160 905973 SGTC_3206 9114350 49.47 µM 1.112420672842 0.146253021537889 no 550 0.132978660096702 144 17087243 SGTC_22 0964-0034 14.468 µM 1.10954493850202 0.146868128919235 no 551 0.133597584719971 194 138402 SGTC_1467 k284-1082 293 µM 1.10811574322039 0.147174472321699 no 552 0.133905916357419 169 3334705 SGTC_3232 9132874 49.47 µM 1.10669780941074 0.147478824888098 no 553 0.134212301402741 153 3784940 SGTC_1084 voriconazole 435 nM 1.10528915837585 0.147781602226224 no 554 0.13451715708894 175 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1145 3546-0597 10.2 µM 1.10489884570878 0.147865570145114 no 555 0.134601711328768 151 875334 SGTC_3102 9121669 49.47 µM 1.10468445681074 0.147911705192184 no 556 0.134648170357293 169 41905072 SGTC_1888 azatryptophan 97.5 µM 1.10449746236248 0.147951953005303 no 557 0.13468870187154 133 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2360 9040895 200 µM 1.10276058409931 0.148326140852126 no 558 0.135065574646292 142 4914414 SGTC_2510 benzyl isothiocyanate 8.31 µM 1.10216836253135 0.148453871887762 no 559 0.135194241733281 196 2346 DNA damaging agent; causes G2/M arrest. SGTC_67 0335-0847 266 µM 1.10213932904526 0.148460135754716 no 560 0.135200551759132 170 4552207 YOR254C SEC63 SGTC_625 k213-0058 121 µM 1.09868927458854 0.149205730696567 no 561 0.135951811196532 191 3655420 SGTC_529 4076-0302 30.3 µM 1.0964555513338 0.149689794337292 no 562 0.136439732437635 162 5816522 SGTC_1784 st039334 36.3 µM 1.09580245443162 0.149831522793589 no 563 0.136582617077226 180 3496984 SGTC_1758 st042942 75.2445 µM 1.09531165481948 0.149938090026187 no 564 0.136690061612278 171 669317 SGTC_1356 1502-0781 85.8 µM 1.09468663754929 0.150073873066247 no 565 0.136826972353095 173 567702 SGTC_48 0382-0018 55 µM 1.0910145127574 0.150873285959509 no 566 0.137633248358256 130 762596 SGTC_812 4251-0442 148 µM 1.08831730623237 0.151462263855958 no 567 0.138227526536023 170 5723007 SGTC_2211 7117706 200 µM 1.08372514363681 0.152468548231764 no 568 0.139243341937096 147 822771 SGTC_1947 st076332 61.6 µM 1.07977137186907 0.153338487917203 no 569 0.14012200122678 177 24208416 SGTC_1641 st009299 47.1 µM 1.07741475720698 0.153858569760273 no 570 0.140647507121776 163 4046054 SGTC_3207 9114163 49.47 µM 1.07510538234902 0.154369357540124 no 571 0.141163775000566 186 849233 SGTC_731 3966-0296 387 µM 1.07462117069148 0.154476597551348 no 572 0.141272184753513 156 660956 SGTC_3159 9100096 49.47 µM 1.074548005311 0.154492806020185 no 573 0.141288570597872 137 25236875 SGTC_196 k015-0023 18.111 µM 1.07449197594613 0.154505219074256 no 574 0.141301119595443 144 5211998 SGTC_1063 disulfiram 1.84 µM 1.07428410878898 0.154551276868826 no 575 0.141347682577194 177 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1140 3229-1848 2.98 µM 1.07353909510346 0.154716426487779 no 576 0.141514653719008 155 2849525 SGTC_757 1066-0008 322 µM 1.07329095559924 0.154771458259372 no 577 0.141570295961171 176 6842497 SGTC_2581 avocatin a 64 µM 1.07119378199495 0.15523708075334 no 578 0.142041153442095 160 6710728 A skin care supplement. SGTC_2183 6420625 130.508 µM 1.07028155683727 0.155439904739417 no 579 0.142246296737423 186 2897619 SGTC_2421 5690543 90.72 µM 1.06613795211128 0.156363393080986 no 580 0.143180642834004 183 3397993 SGTC_790 1575-0012 79.1 µM 1.06429973690931 0.156774232277392 no 581 0.143596468571949 183 378741 YLR208W SEC13 SGTC_1769 st044406 64.4 µM 1.06255674898701 0.157164443831309 no 582 0.143991504921816 210 670903 SGTC_733 4069-0007 56.1 µM 1.06247147882749 0.157183550067773 no 583 0.144010849610773 175 5717425 YNL287W SEC21 SGTC_2441 5730946 39.09 µM 1.06236763119596 0.157206820966972 no 584 0.144034411217527 154 1774275 SGTC_1053 3366-3204 134 µM 1.062047774983 0.157278510804356 no 585 0.14410699855019 170 3632071 YPR165W RHO1 SGTC_2934 9036370 36.88 µM 1.05722026652919 0.158363117115565 no 586 0.14520553626316 146 6462800 SGTC_2887 9044784 58.44 µM 1.05470133965097 0.158930993210912 no 587 0.145780969456122 198 6465546 SGTC_1839 st053978 48 µM 1.05171169966156 0.159606718288202 no 588 0.146465920779662 156 3788398 SGTC_1859 st055998 20 µM 1.05110844548536 0.159743294780845 no 589 0.146604392833144 164 676301 SGTC_1744 st037937 38.9 µM 1.05067585742613 0.159841279598406 no 590 0.146703743951078 171 1016152 SGTC_3148 9097893 49.47 µM 1.04822465567538 0.160397239727159 no 591 0.147267556742035 167 17174100 SGTC_19 0279-0214 38.434 µM 1.04799718836781 0.160448895864179 no 592 0.147319951143305 178 3566274 YBR002C RER2 SGTC_2697 mebhydrolin 72.4 µM 1.04633254539873 0.160827254716804 no 593 0.147703762162971 162 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_85 0868-0259 160.055 µM 1.04391902246476 0.161376861160519 no 594 0.148261428206269 159 83173 SGTC_586 0957-0265 8.15 µM 1.03843722052506 0.162629719907429 no 595 0.14953327434784 184 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2977 9011197 71.43 µM 1.03792807981778 0.162746403653238 no 596 0.149651769763937 190 2704722 SGTC_1190 1486-1332 13 µM 1.03735181677564 0.162878536023222 no 597 0.149785962535984 177 4150046 SGTC_2657 nystatin 74.44 µM 1.03670544008021 0.163026827855153 no 598 0.149936577960977 163 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2825 7998094 58.44 µM 1.03478829715949 0.163467175062122 no 599 0.150383894723504 163 2987815 SGTC_3324 9138759 60.749 µM 1.03120528079556 0.16429222455598 no 600 0.151222282391142 161 45595710 SGTC_712 r015-0009 80.6 µM 1.02807271805934 0.165015757904508 no 601 0.151957811393121 162 6813872 YLR060W FRS1 SGTC_1114 scopoletin 1.73284 µM 1.02728130717765 0.165198877381857 no 602 0.152144010901753 171 5280460 A coumarin with genotoxic properties. SGTC_3156 9099931 49.47 µM 1.02651168615147 0.165377081137296 no 603 0.152325229038425 186 18111053 SGTC_670 4204-0025 119 µM 1.02393711215026 0.165974120660802 no 604 0.152932489812169 164 719039 SGTC_270 tamoxifen 5.46 µM 1.02129861811568 0.166587426487711 no 605 0.153556490470227 193 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1228 0124-0032 52.5 µM 1.01796109437949 0.167365311157648 no 606 0.154348222808502 157 X1228 SGTC_564 3555-0129 330 µM 1.01669865279258 0.167660160633614 no 607 0.154648403418117 181 563260 SGTC_1481 3346-2004 36 µM 1.01638318899303 0.16773389097557 no 608 0.154723473918752 201 2770522 SGTC_1801 st050089 28.441 µM 1.01616284193301 0.16778540297342 no 609 0.15477592389567 184 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_653 0203-0016 55.2 µM 1.01495239094179 0.168068559798565 no 610 0.155064261237862 191 295302 SGTC_1332 1480-0653 17.5 µM 1.01485624626359 0.168091063782375 no 611 0.155087178723873 165 5749438 SGTC_1311 1190-0148 100 µM 1.01378437765942 0.168342080661078 no 612 0.155342825672044 192 1961333 SGTC_210 3551-0445 56.827 µM 1.01376397615671 0.168346860749188 no 613 0.155347694245583 166 2865180 YOR207C RET1 SGTC_2346 9031566 143.75 µM 1.01128235535693 0.168928957530796 no 614 0.155940654318846 170 4771086 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.00662637341684 0.170024563387417 no 615 0.157057177841083 164 5379071 SGTC_2167 5876490 200 µM 1.00538695432929 0.170316978760832 no 616 0.15735527958022 187 686534 SGTC_636 0kpi-0074 126 µM 1.00375445146059 0.170702625456397 no 617 0.157748491985628 174 616434 SGTC_1806 st050005 60.3 µM 1.00342397004874 0.170780763165518 no 618 0.157828171795733 184 5194765 SGTC_2226 7298446 200 µM 1.00323549194381 0.170825336426498 no 619 0.157873626123577 154 3283010 SGTC_250 brefeldin a 552.239 µM 1.00263786265753 0.170966719232622 no 620 0.15801781024685 163 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2459 5811157 9.22 µM 1.00201456366752 0.171114254519192 no 621 0.158168279515977 182 2870684 YBR192W RIM2 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.998731606560493 0.171892675998344 no 622 0.15896236265484 172 688667 SGTC_2950 9072895 21.46 µM 0.9986262511892 0.171917694183993 no 623 0.158987889248299 179 17332245 SGTC_302 1094-0063 18.9 µM 0.99688086377226 0.172332500421759 no 624 0.159411170650344 210 5440289 SGTC_1645 Cervolide 78 µM 0.995961401463876 0.172551275060501 no 625 0.159634449844825 183 23173 A fragrance. SGTC_2688 kanamycin b 96.69 µM 0.992633426146444 0.173344605253095 no 626 0.160444314525871 199 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_485 niflumic acid 177 µM 0.991511150010209 0.173612658693595 no 627 0.160718025283605 180 4488 A COX2 inhibitor. SGTC_1648 st011736 69.8 µM 0.990002543286638 0.173973401756695 no 628 0.161086437956899 195 2855514 SGTC_2893 9048488 25.97 µM 0.989316726995755 0.174137553896001 no 629 0.161254101317642 184 6467338 SGTC_1833 st055984 71 µM 0.988766719009259 0.174269271029883 no 630 0.161388645481453 167 676288 SGTC_707 0865-0008 204 µM 0.988578619446811 0.174314332054872 no 631 0.161434675605534 197 723043 SGTC_2768 sulfasalazine 50.2 µM 0.987610297298896 0.174546419897376 no 632 0.161671770620039 171 5384001 An antioxidant and salicylic acid derivative. SGTC_1767 st044992 70.3 µM 0.987170737604212 0.174651838472436 no 633 0.161779472278356 188 9600693 SGTC_2817 7995342 71.43 µM 0.986887859962339 0.174719701731014 no 634 0.161848808156313 169 18879975 SGTC_2502 avocadyne acetate 18.59 µM 0.981458637459166 0.176025432481347 no 635 0.163183311072063 170 3952079 SGTC_2252 omeprazole 400 µM 0.979370012749849 0.176529389080905 no 636 0.163698594157369 163 4594 A proton pump inhibitor. SGTC_197 4544-0043 41.561 µM 0.979294368993673 0.176547657992478 no 637 0.163717275972501 195 896523 SGTC_443 clozapine 122 µM 0.979180821069775 0.176575083478334 no 638 0.163745321616277 187 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_683 panaxydol 45 µM 0.977820830583377 0.176903774411689 no 639 0.164081473305415 160 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1747 st037496 66.6 µM 0.976050770707525 0.177332152199904 no 640 0.16451965266999 210 723305 SGTC_1962 st076595 64.5 µM 0.974113967134941 0.177801633936411 no 641 0.164999977640257 198 279619 SGTC_2151 5563267 85.4165 µM 0.972848753241352 0.178108745127649 no 642 0.165314238987786 210 5310824 SGTC_2290 7904846 200 µM 0.971382781152068 0.178465005218255 no 643 0.165678849893423 180 2962154 SGTC_2960 9079389 5.97 µM 0.971047947992226 0.178546439201618 no 644 0.165762201193075 157 16457355 SGTC_2278 7948257 134.34 µM 0.968611401195226 0.179139730606976 no 645 0.166369556350005 184 1247028 SGTC_611 3453-1652 23.7 µM 0.967802319095915 0.179337013486415 no 646 0.166571552693847 211 1560575 SGTC_1674 st016616 23.6 µM 0.966016651386742 0.179772905787214 no 647 0.167017924465201 184 625830 SGTC_253 dyclonine 31.25 µM 0.964436754568961 0.180159122622246 no 648 0.167413501277611 176 3180 An oral anasthetic. SGTC_2864 9034755 47.6 µM 0.964337965388215 0.180183289618169 no 649 0.16743825629197 181 4930451 SGTC_675 1309-0189 238 µM 0.964108959779498 0.180239319545975 no 650 0.167495650564648 177 4246530 SGTC_2282 7944268 200 µM 0.963238477960188 0.180452396772392 no 651 0.167713929730308 181 2970414 SGTC_2620 irigenin 100 µM 0.962588830139658 0.180611521007603 no 652 0.167876952603032 206 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1591 genipin 88.4 µM 0.96255302306285 0.180620294123267 no 653 0.167885941009911 187 442424 A DNA cross-linking agent. SGTC_173 1273-0061 2.693 µM 0.957760713793602 0.181796871617442 no 654 0.169091716817441 202 2847414 YPL266W DIM1 SGTC_318 1488-0629 67.2 µM 0.957642410400361 0.181825977227255 no 655 0.16912155287895 187 3662576 SGTC_3176 9106582 49.47 µM 0.955562319057664 0.182338208097364 no 656 0.169646703172932 137 17018027 SGTC_2263 7948595 193.29 µM 0.954784935653895 0.182529873119225 no 657 0.169843233509743 180 2971371 SGTC_1024 4507-0395 26 µM 0.954569303406148 0.182583059852059 no 658 0.169897773361825 183 4201836 SGTC_2626 ethyl orsellinate 100 µM 0.95437213883077 0.182631699914355 no 659 0.169947652012843 208 75653 A natural product. SGTC_2127 5253358 187.912 µM 0.953021609652217 0.182965089955308 no 660 0.170289560929043 172 20612 SGTC_2654 protoveratrine a 100 µM 0.952848055590645 0.183007960827021 no 661 0.170333530956779 220 5702278 A heart drug and vasodilator. SGTC_2341 7987486 176.74 µM 0.952598057401601 0.183069725743433 no 662 0.170396880932872 182 1258686 SGTC_3117 9124945 49.47 µM 0.952404650315222 0.183117518100869 no 663 0.170445900976862 166 17592065 SGTC_115 0527-0192 112.043 µM 0.947410309296558 0.184354352000344 no 664 0.1717148699396 233 4233931 SGTC_2078 5212016 200 µM 0.946554789774405 0.184566739141357 no 665 0.171932845380875 184 1899708 SGTC_2145 5634607 200 µM 0.942437465305575 0.185591013182926 no 666 0.172984356693573 179 308662 SGTC_2638 epoxomicin 18 µM 0.941705963176832 0.185773358572467 no 667 0.173171600592144 177 9915668 A protesome inhibitor. SGTC_828 2074-0507 139 µM 0.940250550791508 0.186136487255736 no 668 0.173544528819963 196 X828 SGTC_408 cantharidin 100 µM 0.938754876380754 0.186510119430271 no 669 0.173928305674774 179 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3129 9127257 49.47 µM 0.938258300314156 0.186634270984833 no 670 0.174055841949881 187 837894 SGTC_624 k048-0052 28 µM 0.936999446210405 0.186949232822918 no 671 0.174379421391038 176 6835531 SGTC_2037 5169046 200 µM 0.936264173676421 0.187133348039851 no 672 0.174568594613326 193 5718022 SGTC_2886 9058944 51.95 µM 0.935323250605728 0.187369122502048 no 673 0.174810868272404 149 4949929 SGTC_2043 5101342 149 µM 0.931609440860559 0.188301512445236 no 674 0.175769201158389 206 678451 SGTC_1458 k015-0034 6.33 µM 0.928111050822682 0.189182432325694 no 675 0.176674983930889 185 3598957 SGTC_589 1227-0070 34.1 µM 0.927655391855512 0.189297357041559 no 676 0.176793177356209 192 2841384 SGTC_577 r071-0003 38.6 µM 0.926689517938159 0.189541108461779 no 677 0.177043880710841 224 4568517 YMR134W ERG29 SGTC_3353 9151644 39.2805 µM 0.924883916289866 0.189997294253385 no 678 0.177513146847454 193 4909158 SGTC_2686 alizarin 95.37 µM 0.922208070740174 0.190674587355094 no 679 0.17821002705308 180 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_1683 st010134 710 nM 0.920581271730215 0.19108707581724 no 680 0.178634541885264 185 3818134 SGTC_2546 rhodinyl acetate 100 µM 0.920286394604428 0.191161902913231 no 681 0.178711558485988 207 6708682 SGTC_2845 9003024 42.97 µM 0.919980530073173 0.191239537117701 no 682 0.1787914668851 193 2990173 SGTC_851 0394-0702 453 µM 0.918628353562571 0.191582976628772 no 683 0.17914499815163 218 762646 SGTC_2085 5307070 144.047 µM 0.918369504834508 0.19164876471392 no 684 0.179212725167593 220 2840351 SGTC_2024 5144227 134 µM 0.91793017040867 0.191760456077694 no 685 0.179327712597415 193 3475211 SGTC_244 nsc-207895 1.295 µM 0.917801827530692 0.19179309202535 no 686 0.17936131265858 159 42640 SGTC_1224 0823-0416 294 µM 0.916432430123518 0.192141523910246 no 687 0.179720066191064 197 3598164 SGTC_1610 st001799 48.1 µM 0.916284595023669 0.192179162480383 no 688 0.179758822845454 190 621897 SGTC_2204 7233102 200 µM 0.916231460598356 0.192192691518388 no 689 0.179772753922582 187 2172480 SGTC_1646 st011709 75.6 µM 0.914218669098289 0.19270561560432 no 690 0.180300978127066 202 5757843 SGTC_1127 asiatic acid 681.4 nM 0.913511913921133 0.192885917819334 no 691 0.180486685263903 204 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_208 k072-0098 12.366 µM 0.911327661903933 0.193443799236017 no 692 0.181061377825033 214 5948901 SGTC_2262 9014885 67.46 µM 0.910765535859876 0.19358753137162 no 693 0.18120946255568 193 6457424 SGTC_1169 aniline yellow 25.8 µM 0.910213657077071 0.193728706689611 no 694 0.181354921552454 218 6051 A DNA damaging agent. SGTC_237 nikkomycin 200 µM 0.907426164475678 0.194442729890601 no 695 0.18209073922233 210 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3151 9099821 49.47 µM 0.904604675915282 0.195167090280711 no 696 0.182837428635303 213 17174189 SGTC_1327 1436-0082 2.18 µM 0.901586767921515 0.195943689963192 no 697 0.18363821132249 207 15992205 SGTC_2931 9014674 55.67 µM 0.901116126410738 0.196064969132858 no 698 0.183763289746169 207 2996810 SGTC_2782 7736369 71.43 µM 0.900167494594094 0.196309559511842 no 699 0.184015560865066 221 2950836 YOL077C BRX1 SGTC_817 1391-0715 46 µM 0.899479628535224 0.196487031018542 no 700 0.184198620940343 226 1353946 SGTC_578 3460-0051 92 µM 0.899359635463234 0.196517999547378 no 701 0.184230566003055 243 2876744 SGTC_1832 st054113 55 µM 0.897194766096337 0.197077229857273 no 702 0.184807498785235 197 1251267 SGTC_1605 st000082 49.1 µM 0.896689774393906 0.197207818005187 no 703 0.184942239290433 213 1114022 SGTC_1571 st070080 73.4 µM 0.896141484937187 0.197349661981947 no 704 0.18508860148392 187 4315245 SGTC_1608 st001473 40.5 µM 0.89051887332226 0.198807804984201 no 705 0.186593669442558 243 7292267 SGTC_3318 9139014 38.6185 µM 0.886105600187695 0.199956860535199 no 706 0.187780312786711 240 16643984 SGTC_1390 3413-2614 145 µM 0.884871698633811 0.20027883648178 no 707 0.188112916856247 238 3421432 SGTC_1128 3448-9350 235 µM 0.884364978201003 0.200411150982026 no 708 0.188249611026846 190 619386 SGTC_3011 9081274 71.4286 µM 0.882217846905995 0.200972390842067 no 709 0.188829506294145 211 6625322 SGTC_2285 7945142 200 µM 0.882153531293702 0.200989216868391 no 710 0.188846893559766 206 2970608 SGTC_392 N-ethylmaleimide 8.33 µM 0.878809621523328 0.20186520262111 no 711 0.189752254280002 227 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_200 k038-0079 37.545 µM 0.877980648050321 0.202082717322515 no 712 0.189977110372725 227 3436683 SGTC_970 1315-0089 19.5 µM 0.877659622626316 0.202166988979978 no 713 0.190064231349754 197 6811083 YLR033W RSC58 SGTC_2356 9061756 188.97 µM 0.877539013527703 0.202198655234309 no 714 0.190096969003662 201 20104043 SGTC_1007 4101-0031 70 µM 0.875661732272043 0.202691923095677 no 715 0.190606977402787 236 1146276 SGTC_2514 salinomycin 42.74 µM 0.874852803723064 0.202904695836893 no 716 0.190827000914224 224 23682228 A polyether potassium ionophore. SGTC_928 2764-0428 58.7 µM 0.873166491929373 0.203348675687993 no 717 0.191286167951297 225 662578 SGTC_3000 9075062 71.4286 µM 0.871918394527021 0.203677653442829 no 718 0.191626448998756 209 17057871 SGTC_3059 1327-0034 3 µM 0.870425657831947 0.204071530504082 no 719 0.192033915008354 208 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2610 ononetin 44.17 µM 0.868253186814521 0.204645573906658 no 720 0.192627871707447 207 259632 SGTC_3179 9107801 49.47 µM 0.866587937601332 0.205086241146008 no 721 0.193083912512886 191 4818259 SGTC_610 4215-0184 155 µM 0.865619751675222 0.205342706792977 no 722 0.193349360167491 214 5605015 SGTC_1594 piperine 70.1 µM 0.862909321461498 0.206061693117795 no 723 0.194093662599207 201 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1559 coumarin 343 70.1 µM 0.862158917393779 0.206261013731799 no 724 0.194300036737257 213 108770 A hepatotoxic, DNA x-linker. SGTC_1396 3511-0007 98.6 µM 0.860744155628418 0.206637110197046 no 725 0.194689484017053 218 X1396 SGTC_2805 7950783 58.44 µM 0.860045218632273 0.206823063512014 no 726 0.194882058413976 201 1178958 YDL195W SEC31 SGTC_1623 st003709 20.3 µM 0.859953353841323 0.206847511651157 no 727 0.194907378042173 224 16192618 SGTC_1056 3448-1962 115 µM 0.859018859841797 0.207096307384825 no 728 0.195165055458727 217 715507 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.858303205961926 0.207286959694949 no 729 0.1953625298119 191 77254 SGTC_2068 5226020 147 µM 0.85692784945778 0.207653649990523 no 730 0.19574238021589 227 1810509 SGTC_1838 st055369 84.5 µM 0.856736860170606 0.207704600834854 no 731 0.195795163680038 206 676036 SGTC_1219 1469-0211 33.1 µM 0.85485107828925 0.208208073445292 no 732 0.196316798400295 232 6822282 SGTC_1001 4048-4355 44.4 µM 0.8543197128684 0.208350069172007 no 733 0.196463933810977 225 21824233 SGTC_2545 solidagenone 89.61 µM 0.854308367469 0.208353101603283 no 734 0.196467076087516 175 6708572 An anti ulcer agent SGTC_1456 k015-0012 13 µM 0.851132242826608 0.209203048785296 no 735 0.197347948205062 236 2989616 SGTC_60 0986-0278 202 µM 0.850356959372401 0.209410828109257 no 736 0.19756332886664 221 3110598 SGTC_455 paf C-16 10 µM 0.848838847282276 0.209818040229932 no 737 0.197985485298647 203 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3163 9099914 49.47 µM 0.848116830955138 0.21001187413668 no 738 0.198186454544646 237 16268368 SGTC_898 1000-0849 28.3 µM 0.846430629067423 0.210464964763389 no 739 0.198656278904107 257 6751807 SGTC_1851 st056236 18.9 µM 0.846417493141634 0.210468496701196 no 740 0.198659941585588 215 5393171 SGTC_2520 obtusaquinone 4.71 µM 0.845297807249619 0.210769681436637 no 741 0.198972292518639 225 5967872 SGTC_1014 4130-3005 69.3 µM 0.843528354993443 0.21124616214924 no 742 0.199466507210389 216 743608 SGTC_2838 9002687 71.43 µM 0.84298951742485 0.211391386382657 no 743 0.199617153225674 235 6457060 SGTC_2186 6124449 200 µM 0.842749035842788 0.211456218387138 no 744 0.19968440817839 225 3834182 YLR033W RSC58 SGTC_2179 6298986 200 µM 0.841234050008067 0.211864914690406 no 745 0.200108414314745 216 738374 SGTC_1307 1187-1599 12.2 µM 0.83596319581896 0.213290424107863 no 746 0.201587804155106 238 1538471 SGTC_822 1487-0950 154 µM 0.835412721597067 0.21343962242803 no 747 0.201742684741427 210 1958375 SGTC_1687 st020778 55.3625 µM 0.83291071937488 0.214118521196634 no 748 0.202447541835403 219 4259299 SGTC_2975 9084847 53.72 µM 0.832158811922683 0.214322790715116 no 749 0.202659654514585 211 27211724 SGTC_413 propylparaben 100 µM 0.831072761307415 0.214618036387988 no 750 0.202966263155736 219 7175 A pharmaceutical preservative. SGTC_2408 sulbentine 18.36 µM 0.828100846405295 0.215427166667203 no 751 0.203806695110656 220 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1012 4112-3522 18 µM 0.827684285570824 0.215540720296376 no 752 0.20392466045935 215 3112398 SGTC_1662 st014054 52 µM 0.826641153967735 0.215825228087373 no 753 0.204220242075203 232 2838777 SGTC_451 chloral hydrate 100 µM 0.825320348754584 0.216185781743431 no 754 0.204594871067533 234 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2385 9074692 200 µM 0.824503250097384 0.216409008008432 no 755 0.204826834922624 211 17046906 SGTC_2711 st079103 59.1 µM 0.823545154554859 0.216670923581281 no 756 0.205099025103329 221 54693780 SGTC_308 4092-1169 104 µM 0.822357192427554 0.21699593248386 no 757 0.205436817586184 230 2268590 YDL196W YDL196W SGTC_1751 st044839 27.194 µM 0.822244992352399 0.217026643323527 no 758 0.205468738314405 218 5291326 SGTC_3212 9128307 49.47 µM 0.822160231208879 0.217049845382363 no 759 0.205492854666579 193 27243542 SGTC_56 0957-0365 83.25 µM 0.821764190399065 0.217158274453706 no 760 0.205605558990585 208 6752360 SGTC_99 0109-0120 622.8 µM 0.821137085911038 0.217330028721385 no 761 0.205784093883445 241 759414 SGTC_3352 9151559 45.5865 µM 0.820637913284906 0.217466800476433 no 762 0.205926272666317 206 17159339 SGTC_2469 5655019 90.81 µM 0.818960362700442 0.217926808070253 no 763 0.206404514311248 232 2788239 SGTC_2489 cantharidin 73.42 µM 0.816826635550644 0.218512715526645 no 764 0.207013754190864 231 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2011 4012611 177 µM 0.81316956308425 0.219519030285896 no 765 0.208060423759164 220 2049887 SGTC_61 0978-8327 98.565 µM 0.812130591678212 0.219805408347668 no 766 0.208358350567715 227 6150059 YHR072W ERG7 SGTC_574 1315-0397 40 µM 0.810851467335313 0.220158275598428 no 767 0.208725487031082 265 6794277 SGTC_1798 st045719 60.953 µM 0.80845020231779 0.220821580276131 no 768 0.209415731001198 223 3980186 SGTC_756 0508-1999 28.3 µM 0.807277772390224 0.221145857479421 no 769 0.209753233552985 246 6753853 SGTC_3259 9138485 49.47 µM 0.807182851173804 0.221172123235178 no 770 0.209780572117507 215 17646153 SGTC_1400 3771-8998 51.5 µM 0.803492085334586 0.222194782100756 no 771 0.210845184773238 214 670767 SGTC_1913 st060213 96.1 µM 0.802611076681758 0.222439295452734 no 772 0.211099782047962 245 688959 SGTC_3331 9141060 1.957 µM 0.801109911273343 0.222856279162423 no 773 0.211534009435687 223 4906567 YPR165W RHO1 SGTC_2181 6316240 54.2555 µM 0.800546665477867 0.223012848644877 no 774 0.211697068844044 231 12779990 SGTC_2201 6605497 169.863 µM 0.797992274178123 0.223723696949861 no 775 0.212437486747585 233 670741 SGTC_2236 dapsone 200 µM 0.795777734502319 0.224341010831004 no 776 0.213080617709465 229 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_165 k038-0023 64.381 µM 0.795164666465615 0.224512077310462 no 777 0.213258861133206 232 46368543 SGTC_1154 4088-0362 150 µM 0.79371496377234 0.2249168871356 no 778 0.213680693457736 240 6618304 SGTC_992 3909-8734 162 µM 0.793692799063742 0.224923079539525 no 779 0.21368714668181 232 4288319 SGTC_1142 3253-1408 9.78 µM 0.793647605188023 0.224935706160284 no 780 0.213700305167585 236 256655 SGTC_2910 7948405 25.97 µM 0.793605865003025 0.224947368218628 no 781 0.213712458508486 219 2971328 SGTC_784 4579-0127 173 µM 0.793187651139449 0.225064234593005 no 782 0.213834250572012 241 1948547 SGTC_1274 0865-0114 173 µM 0.791685950771796 0.225484155668741 no 783 0.214271908103777 234 870624 SGTC_1328 1441-0025 69.2 µM 0.790257358246339 0.225884044866455 no 784 0.214688742222769 228 4562601 SGTC_2652 actinonin 100 µM 0.789374029179861 0.226131505351408 no 785 0.214946715199851 248 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1092 toremifene 6.32 µM 0.785649795803236 0.227176514797031 no 786 0.216036341470899 244 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1419 3993-2473 62.6 µM 0.785466087644958 0.227228133142087 no 787 0.216090172994088 253 704026 SGTC_21 0849-0113 22.993 µM 0.784592508581134 0.227473681943947 no 788 0.216346261879908 246 1560156 SGTC_2862 9027634 71.43 µM 0.783903303605861 0.227667511621779 no 789 0.216548425585641 239 5012562 SGTC_417 st075190 100 µM 0.782287044244092 0.228122427436046 no 790 0.217022949550054 260 222757 SGTC_1264 0783-0040 158 µM 0.780754790898369 0.228554170310311 no 791 0.217473364226799 247 2855798 SGTC_885 0865-0106 16.8 µM 0.779476041587384 0.228914834454162 no 792 0.217849672689747 245 2793380 SGTC_507 nimesulide 162 µM 0.776513929825086 0.229751507208299 no 793 0.21872279962786 235 4495 A COX2 inhibitor. SGTC_483 fpl-64176 144 µM 0.773636144841385 0.230565998604584 no 794 0.219572995573 234 3423 SGTC_2882 9058044 58.44 µM 0.772702268791292 0.230830657289552 no 795 0.219849301825687 244 18076804 SGTC_520 3584-0023 682 µM 0.770882910290114 0.231346746893319 no 796 0.220388168809111 241 1340790 SGTC_526 4469-0568 170 µM 0.768463080349304 0.232034165736841 no 797 0.221106058305012 229 2901964 SGTC_1074 carmofur 3.8 µM 0.765964161344919 0.232745243956409 no 798 0.2218488135002 265 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_668 1682-0499 62.6 µM 0.764044795836816 0.233292228980576 no 799 0.222420274033567 252 682214 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.763138105244172 0.233550867553392 no 800 0.222690518440407 242 94937 An inhibitor of serotonin biosynthesis. SGTC_2920 7982904 15.77 µM 0.763093899483919 0.233563481558401 no 801 0.222703699007479 234 6456808 SGTC_608 k048-0125 159 µM 0.762574239541293 0.233711793567533 no 802 0.222858676236169 247 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2340 7987427 183.45 µM 0.762404150865272 0.233760348560999 no 803 0.222909414812954 240 2239331 SGTC_3229 9132204 49.47 µM 0.76180110989429 0.233932542929416 no 804 0.223089358938755 236 17682924 SGTC_1631 benzylvanillin 81.9 µM 0.761272109851254 0.234083653243346 no 805 0.223247277737831 236 75506 SGTC_2109 5483026 200 µM 0.76093056573725 0.234181244967618 no 806 0.22334927038146 293 759335 SGTC_370 0180-0345 38.7 µM 0.760930140963034 0.23418136635527 no 807 0.223349397244964 230 3989527 SGTC_723 4182-0001 115 µM 0.760478823767397 0.234310358870191 no 808 0.223484211267394 239 744821 YLR208W SEC13 SGTC_2414 st077232 92.9 µM 0.759879925336025 0.234481592785753 no 809 0.223663181078724 243 729801 SGTC_1104 tacrolimus 29.8 µM 0.759364286655535 0.234629076953703 no 810 0.223817335506656 249 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1176 0848-0131 83.3 µM 0.759314522815091 0.234643313236372 no 811 0.223832216011042 256 6769040 SGTC_1762 st045503 25.4615 µM 0.758393122090836 0.234906990937562 no 812 0.224107837064728 242 4645554 SGTC_1873 rapamycin 2 nM 0.757669843535511 0.235114086584786 no 813 0.2243243282903 235 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_464 bw-b 70c 158 µM 0.757606899195363 0.235132114145292 no 814 0.224343174359507 263 5353454 SGTC_2531 methyl deoxycholate 70.07 µM 0.757182702450489 0.235253626031838 no 815 0.22447020589797 263 16667744 Haematoxylin. SGTC_1521 st012942 49.4 µM 0.756157381415306 0.235547474134842 no 816 0.224777420864568 234 24207259 SGTC_2822 7994718 71.43 µM 0.755395721860086 0.235765890165763 no 817 0.225005789703472 288 1018011 SGTC_1831 st055328 12 µM 0.755333600903967 0.23578370910222 no 818 0.225024421264469 247 1103068 SGTC_2787 5284540 71.43 µM 0.755169907575714 0.235830666877934 no 819 0.225073520997021 262 736958 SGTC_503 tyrphostin 8 294 µM 0.753513044340893 0.236306251905668 no 820 0.225570837854184 267 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3095 9117207 49.47 µM 0.752611702869706 0.23656519403677 no 821 0.225841641542226 225 17015229 SGTC_2572 astragaloside iv 100 µM 0.748341612188295 0.237794047553085 no 822 0.227127065499902 250 45006101 An anti-inflammatory agent. SGTC_2962 9082311 13.18 µM 0.747811760867475 0.237946772804499 no 823 0.22728685359593 265 16459453 SGTC_2205 7238770 200 µM 0.745750654244671 0.238541380861188 no 824 0.227909026861281 238 279867 SGTC_2055 5235184 200 µM 0.744064595458888 0.23902839565869 no 825 0.228418698531367 272 2836034 SGTC_1373 2887-0003 58.5 µM 0.743080667064784 0.239312852429173 no 826 0.228716421805255 272 776948 SGTC_3351 9150312 21.596 µM 0.741027458863779 0.239907036441929 no 827 0.229338395684216 263 4904905 SGTC_795 0685-0265 78 µM 0.74071182085196 0.239998451165723 no 828 0.229434095232472 247 302754 SGTC_493 zm226600 134 µM 0.739570900047815 0.240329041712434 no 829 0.229780202159109 280 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1874 staurosporine 7.6 µM 0.739501274328719 0.240349224326956 no 830 0.229801333106795 265 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1969 st069479 40.1 µM 0.739499307995183 0.24034979432732 no 831 0.229801929891885 265 3895485 SGTC_212 3807-4682 38.772 µM 0.736265361967832 0.241288245792985 no 832 0.230784610791969 254 3125501 YBL034C STU1 SGTC_179 1273-0063 6.77 µM 0.733630994748198 0.242054176059369 no 833 0.2315868326569 258 3108139 SGTC_2447 5741742 33.78 µM 0.731990058888561 0.242531936295046 no 834 0.2320873177353 247 1776504 SGTC_1673 st016611 27.3 µM 0.730877589539907 0.242856123200443 no 835 0.232426962813626 282 5226799 SGTC_2310 7668677 200 µM 0.730859179731493 0.24286149001094 no 836 0.232432585787918 263 2197143 SGTC_2669 eugenol 100 µM 0.729713529844636 0.243195595045631 no 837 0.232782654586669 238 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2077 5212015 200 µM 0.728462897382597 0.243560599573866 no 838 0.233165136473181 253 780900 SGTC_119 0121-0043 24.815 µM 0.727824377872729 0.243747069325364 no 839 0.233360549833426 272 1092378 SGTC_2126 5251174 33.877 µM 0.727489017946233 0.243845036866048 no 840 0.233463220216466 258 790722 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.725104014159543 0.244542372357206 no 841 0.234194110992377 262 688662 SGTC_2335 9018011 154.17 µM 0.72504045702541 0.244560970090571 no 842 0.234213605560028 241 6458208 SGTC_316 k060-0003 58.6 µM 0.722711962283316 0.245242846137941 no 843 0.234928432363299 261 6152314 SGTC_1168 k815-0004 80.5 µM 0.722681322205106 0.245251825582289 no 844 0.23493784661939 271 642433 SGTC_973 1325-0077 65.9 µM 0.722616308869609 0.245270879109539 no 845 0.234957822852487 255 2835149 SGTC_1717 st033143 58.0435 µM 0.722244642864257 0.245379818936895 no 846 0.235072040313459 260 674616 SGTC_3270 9137563 49.47 µM 0.722219649687673 0.245387145674032 no 847 0.235079722119501 247 17015724 SGTC_2118 5526350 200 µM 0.721660603585669 0.245551060479928 no 848 0.235251584600745 265 743594 SGTC_2366 9070441 60.58 µM 0.720365164975075 0.245931114797821 no 849 0.235650096060802 254 6837235 SGTC_1867 st057372 64 µM 0.719149180988556 0.246288145821672 no 850 0.236024503695618 243 688837 SGTC_1236 0330-0013 258 µM 0.718530051885943 0.246470038057444 no 851 0.236215262548376 267 4617066 SGTC_2852 9023854 51.95 µM 0.717695270738706 0.246715400024426 no 852 0.236472599969633 282 19798528 SGTC_3202 9113761 49.47 µM 0.715897451126175 0.247244265682375 no 853 0.237027336218241 266 4798415 SGTC_1468 k284-1086 134 µM 0.714429307412409 0.247676599609636 no 854 0.237480877455005 260 15996457 SGTC_1705 st027868 56.3335 µM 0.713380489958547 0.247985698838212 no 855 0.237805171261868 265 292948 SGTC_2936 9038235 15.59 µM 0.711967745003642 0.24840237706767 no 856 0.238242374907297 258 4749415 SGTC_368 fentichlor 4.58 µM 0.709545596734989 0.249117638467889 no 857 0.238992983221159 277 7329 A pesticide. SGTC_563 tetrahydrosecaminediol 614 µM 0.709011861263447 0.249275397951706 no 858 0.239158558119065 270 334274 A psychoactive constituent of the cannabis plant. SGTC_2764 methyldopa 94.69 µM 0.709008059441336 0.24927652187021 no 859 0.239159737741433 272 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.708929600027844 0.249299717135793 no 860 0.23918408269376 271 2374 Ca(2+)-ATPase inhibitor. SGTC_1816 st051957 91.6 µM 0.707792153810843 0.24963611370794 no 861 0.239537169784299 272 674121 SGTC_1137 ixabepilone 100 µM 0.707292712059928 0.249783898365716 no 862 0.239692296808287 264 154225 A novel microtubule stabilizer. SGTC_410 α-linolenic acid 100 µM 0.704936531086255 0.25048171760569 no 863 0.24042486745128 266 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2487 5918373 44.05 µM 0.7038455229323 0.250805186032607 no 864 0.240764490234975 275 2876279 SGTC_550 4123-0385 25.7 µM 0.70213527883368 0.251312693855111 no 865 0.241297401559765 263 5731123 SGTC_2434 5670830 169.91 µM 0.700841008996298 0.251697123651887 no 866 0.241701121171358 285 1549830 SGTC_311 1315-0136 58 µM 0.69883152520542 0.252294604335453 no 867 0.242328662247082 260 6759207 SGTC_1900 st060200 72.8 µM 0.696260588012087 0.253060111174022 no 868 0.243132825140918 260 688945 SGTC_858 0438-0351 2.77 µM 0.694363490560333 0.253625762054623 no 869 0.243727141823807 271 2799119 SGTC_1555 citronellol 128 µM 0.691890630276111 0.254364081931283 no 870 0.24450300760506 267 8842 A terpine precursor. SGTC_798 1287-0182 476 µM 0.690554771890013 0.254763396233096 no 871 0.244922689221104 295 1649755 SGTC_3240 9133527 49.47 µM 0.688146932381655 0.255483974799924 no 872 0.245680129122545 288 17617455 SGTC_1803 st050068 52.4 µM 0.68782565690401 0.255580201292049 no 873 0.245781288557349 283 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1052 3253-3998 198 µM 0.686836158032387 0.255876688919538 no 874 0.246092990737701 261 5450317 SGTC_285 1486-1325 46 µM 0.685946383620271 0.2561434488897 no 875 0.246373459659214 277 22310230 SGTC_1490 4089-0339 670 nM 0.684941297429307 0.256444954403677 no 876 0.246690482363668 275 742542 SGTC_295 k015-0027 31 µM 0.684224825713902 0.256659994252305 no 877 0.246916604039214 276 3887424 SGTC_728 3030-5151 22.5 µM 0.683903534013554 0.256756456343662 no 878 0.24701804114893 275 3125388 SGTC_2771 fluoxetine 41.05 µM 0.682262779034089 0.257249357822454 no 879 0.247536402130836 280 3386 A selective serotonin reuptake inhibitor. SGTC_1506 4226-2149 212 µM 0.68083291003446 0.257679307514763 no 880 0.247988611735461 285 991114 SGTC_62 0180-0423 3.232 µM 0.680344092492016 0.257826376400879 no 881 0.248143305956883 298 30102 YGL099W LSG1 SGTC_1891 st059073 26.2 µM 0.680335291654233 0.257829024678419 no 882 0.248146091596015 278 688754 SGTC_372 0155-0182 15.9 µM 0.678158202848018 0.258484570190664 no 883 0.248835695335439 252 771486 SGTC_559 1550-0661 158 µM 0.677950542969299 0.258547143947239 no 884 0.248901525893737 275 5830875 SGTC_907 3448-6986 75.5 µM 0.677023459316777 0.258826595959601 no 885 0.249195535055879 286 590582 SGTC_2479 5617353 43.85 µM 0.676328074565019 0.259036309212892 no 886 0.249416185930849 289 2731746 SGTC_1621 st003705 32.4 µM 0.676286449440156 0.259048865252173 no 887 0.249429397192992 279 24207032 SGTC_647 0140-0236 81 µM 0.675308686510827 0.259343893719098 no 888 0.249739833113784 267 990837 SGTC_2451 5856223 45.7 µM 0.674123365840596 0.259701782947746 no 889 0.250116442749385 279 2179896 SGTC_480 am 92016 50 µM 0.67358970075502 0.259862998038521 no 890 0.250286101421603 317 2129 K+ channel blocker. SGTC_2171 5739187 198.077 µM 0.672287733116824 0.260256526457424 no 891 0.250700268778883 267 2262761 SGTC_319 1348-1596 45.5 µM 0.671535675450523 0.260483980755443 no 892 0.250939670214446 285 5380505 SGTC_347 4534-1311 26.2 µM 0.66898310787918 0.261256748632982 no 893 0.251753126764017 283 2862016 SGTC_2382 9035899 200 µM 0.668292794999832 0.261465937079851 no 894 0.251973355792611 290 6462679 SGTC_3070 9117005 49.47 µM 0.668272537048419 0.261472077231717 no 895 0.251979820178287 282 8779016 SGTC_2331 7980721 200 µM 0.666923025915312 0.261881278521989 no 896 0.252410651094792 276 2981221 SGTC_466 geldanamycin 89.2 µM 0.665978475533259 0.262167882107276 no 897 0.252712429253203 253 5288382 HSP90 inhibitor. SGTC_82 0054-0107 293.755 µM 0.665120165209458 0.262428457301231 no 898 0.252986818914492 272 3104697 SGTC_2103 5378138 10 µM 0.664390386258272 0.262650115800812 no 899 0.253220242168812 278 244142 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.663722563506176 0.262853040020362 no 900 0.253433947637533 297 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2866 9034245 58.44 µM 0.662383630592183 0.263260128731965 no 901 0.253862695907345 271 6462273 SGTC_1213 1315-0166 115 µM 0.661416808107477 0.263554281191214 no 902 0.254172524866365 275 768401 SGTC_2462 5162487 171.77 µM 0.660973865776218 0.263689100891001 no 903 0.2543145368448 284 2259986 SGTC_1026 k007-1105 30.6 µM 0.654268667094742 0.265734270460112 no 904 0.256469364372323 278 7066794 SGTC_2295 7971645 200 µM 0.653759049215793 0.265890038480865 no 905 0.25663352667439 280 2978226 YKL099C UTP11 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.653727253415608 0.265899758607297 no 906 0.256643770812233 292 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_345 1362-0200 395 µM 0.653281332216578 0.266036097793108 no 907 0.256787462476613 284 1419823 SGTC_1870 st057514 26.5 µM 0.653014849229381 0.266117591136312 no 908 0.256873352755479 288 5393161 SGTC_462 ag-879 158 µM 0.652894983376425 0.266154251515536 no 909 0.256911991658937 306 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2550 chrysin dimethyl ether 71.87 µM 0.650056379031851 0.267023171279451 no 910 0.257827902270562 270 88881 An O-methylated flavonoid and antioxidant. SGTC_2033 5192550 145 µM 0.649429076616822 0.267215386715559 no 911 0.258030537486374 265 182073 SGTC_2488 5268135 45.7 µM 0.648556297399919 0.267482936267886 no 912 0.258312605525909 298 1270356 YLR208W SEC13 SGTC_229 benomyl 22.8748 µM 0.648544537403954 0.267486542204469 no 913 0.258316407255977 281 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2728 chlorpromazine 9.18 µM 0.646602502678511 0.268082359277814 no 914 0.258944618932115 326 2726 A thorazine and dopamine antagonist. SGTC_1254 0550-0035 264 µM 0.645530885687917 0.268411417604925 no 915 0.259291604901524 285 15121435 SGTC_2601 securinine 100 µM 0.645190853308657 0.268515872795707 no 916 0.25940175643383 305 442872 A GABA receptor antagonist. SGTC_1284 0929-0043 16 µM 0.644202386488505 0.268819637788673 no 917 0.259722101790473 281 1239883 SGTC_3317 9138495 8.753 µM 0.644027654330756 0.268873352541539 no 918 0.259778750752266 293 17020139 SGTC_637 1181-0519 7.26 µM 0.643704464342022 0.268972719207022 no 919 0.259883547219716 285 6252091 YGR060W ERG25 SGTC_446 go6976 132 µM 0.643637701778133 0.268993248047642 no 920 0.259905198135168 297 3501 A protein kinase C inhibitor. SGTC_3242 9133940 49.47 µM 0.642321742092088 0.269398053351311 no 921 0.260332150069434 288 17248444 SGTC_3199 9111318 49.47 µM 0.640327559107856 0.270012069959638 no 922 0.260979833749579 272 8548020 SGTC_2175 5807670 165.306 µM 0.640009041399498 0.270110207606549 no 923 0.261083360683574 262 241186 SGTC_3192 9110362 49.47 µM 0.637750267545706 0.270806663951552 no 924 0.261818128928891 313 16649480 SGTC_2736 butenafine 14.65 µM 0.635915573105731 0.271373021253978 no 925 0.26241572587773 293 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_788 1182-0090 188 µM 0.635513929721529 0.271497084448047 no 926 0.262546642340517 281 5715185 SGTC_1379 2144-0755 36.5 µM 0.633206160236857 0.272210475935404 no 927 0.26329951172068 302 5392327 SGTC_652 0437-0092 114 µM 0.631436341209439 0.272758203428554 no 928 0.263877630230735 280 3091274 SGTC_1149 3909-7961 23.3 µM 0.63041115594898 0.273075729937979 no 929 0.26421280686835 277 735261 SGTC_1844 rapamycin 4 nM 0.629606737445435 0.273325007461867 no 930 0.264475957200663 286 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1102 cgs 12066b 26.1 µM 0.628360827924092 0.273711318908143 no 931 0.264883796086875 290 6438352 A 5-HT1B full agonist. SGTC_2376 9072922 81.32 µM 0.627741356739489 0.273903494977799 no 932 0.265086694120585 294 17087968 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.627525784530968 0.273970386724127 no 933 0.265157319915433 287 688669 SGTC_3088 9117578 49.47 µM 0.627393839836571 0.27401133295608 no 934 0.265200552367191 302 678341 SGTC_1016 4226-1401 38 µM 0.62567128802666 0.274546167600818 no 935 0.265765284741771 299 2901613 SGTC_623 k072-0108 16.9 µM 0.625557919001919 0.27458138557416 no 936 0.265802473735647 301 5382803 SGTC_111 0083-0039 52.457 µM 0.624493106861725 0.274912277117928 no 937 0.266151897936908 278 759313 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.6240415596341 0.275052655223649 no 938 0.266300145941631 286 688664 SGTC_2 0422-0095 29 µM 0.623077162165658 0.275352587647616 no 939 0.266616908297315 259 6790840 SGTC_831 k061-1017 217 µM 0.622602797478366 0.275500176462285 no 940 0.266772786203658 307 1240153 SGTC_1739 st037196 92.5 µM 0.620121159976736 0.276272920567308 no 941 0.267589011046038 309 612214 SGTC_1121 fusaric acid 630.51 nM 0.619374912228466 0.276505498553062 no 942 0.267834702202511 275 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2213 7173844 200 µM 0.617708388762901 0.277025238956421 no 943 0.268383790623629 296 892728 SGTC_819 1013-0258 27.7 µM 0.617590044173697 0.277062165383277 no 944 0.268422804477303 304 5753198 SGTC_1886 st057356 49.9 µM 0.615886137897469 0.277594092983889 no 945 0.268984835561899 292 24207747 SGTC_3174 9107204 49.47 µM 0.614849411942895 0.277917983365633 no 946 0.269327086975865 312 3938802 SGTC_2397 5161689 200 µM 0.613711187816624 0.278273795746229 no 947 0.269703097011135 306 2259942 SGTC_1231 0242-0792 125 µM 0.61149227354888 0.278968073023786 no 948 0.270436865952346 304 3707635 SGTC_1742 st038235 28.8875 µM 0.611345031130838 0.279014173577571 no 949 0.270485592568457 316 564103 YBR002C RER2 SGTC_2084 5306078 60.6385 µM 0.611103315151653 0.279089861164311 no 950 0.270565592627085 325 679340 SGTC_1493 4348-0038 111 µM 0.610231681032931 0.27936287545238 no 951 0.270854173046593 323 800424 SGTC_3035 9091303 49.47 µM 0.610116435325502 0.27939898256068 no 952 0.270892340063515 306 25237002 SGTC_808 0711-0032 135 µM 0.609805236330742 0.279496494225778 no 953 0.270995416201174 288 4252555 SGTC_2187 6125751 200 µM 0.607056330199451 0.280358558502003 no 954 0.271906764910615 301 874498 SGTC_622 1348-1566 26.3 µM 0.606745106287117 0.280456240227523 no 955 0.272010041410027 309 7340407 SGTC_1567 st069303 68.4 µM 0.606643557936806 0.280488116079702 no 956 0.27204374342082 319 5581319 SGTC_813 k007-0158 173 µM 0.605768945345598 0.28076272803356 no 957 0.272334097015509 307 6523916 SGTC_1339 1486-1321 22.7 µM 0.605566084453071 0.280826441120975 no 958 0.272401464695804 308 3469382 SGTC_2199 6590217 200 µM 0.604214346065346 0.281251163762342 no 959 0.272850572101454 301 703109 SGTC_1081 sertraline 6 µM 0.601517050608298 0.282099592561269 no 960 0.273747829356722 308 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1436 4092-1007 8.32 µM 0.599826471660246 0.282631988203032 no 961 0.274310944672219 281 2881121 SGTC_855 0428-0020 25 µM 0.598447009500141 0.283066764702795 no 962 0.274770853358706 289 6812414 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.595505757515028 0.28399485381589 no 963 0.275752725844637 323 65057 A dermal irritant. YDR527W RBA50 SGTC_1315 1237-0019 3.69 µM 0.59525667545359 0.284073516537549 no 964 0.27583595556291 286 825140 SGTC_299 1273-0059 1.44 µM 0.5917869858262 0.285170363168103 no 965 0.276996619505361 301 2848077 SGTC_3234 9132280 49.47 µM 0.590206987300428 0.285670504051495 no 966 0.277525944115286 298 17612295 SGTC_1971 st069429 63.5 µM 0.588176927627597 0.286313721543443 no 967 0.278206771118493 302 1246522 YGL099W LSG1 SGTC_2748 diazoxide 86.69 µM 0.586480895812087 0.286851630076309 no 968 0.278776197974018 273 3019 A potassium channel activatior. SGTC_705 1124-0212 310 µM 0.585425943203572 0.287186457198317 no 969 0.279130674403926 339 9554485 SGTC_1800 st050079 29.0735 µM 0.583757497153602 0.287716375852916 no 970 0.27969173875908 319 3645560 SGTC_1189 1431-2119 7.28 µM 0.583071757166265 0.287934309061324 no 971 0.279922497711331 321 3107275 SGTC_2352 9027995 87.8 µM 0.580269817876175 0.288825594856219 no 972 0.280866338841674 309 2997347 SGTC_3118 9124250 49.47 µM 0.576430133760515 0.290049088131373 no 973 0.282162240627319 309 1504786 SGTC_1170 0310-0127 64.8 µM 0.575207896762248 0.290439056050636 no 974 0.282575351378585 342 774975 SGTC_3056 9094900 49.47 µM 0.57493634034396 0.290525732371864 no 975 0.282667175719487 304 25236784 SGTC_3018 9082602 49.47 µM 0.574916585319405 0.290532038321561 no 976 0.282673856261439 320 17332089 SGTC_1208 2323-2347 50.3 µM 0.574782641633204 0.290574795824488 no 977 0.282719153899293 319 5412760 SGTC_3198 9112019 49.47 µM 0.5746463310033 0.290618311925735 no 978 0.282765255580617 351 45595555 SGTC_3271 9137798 49.47 µM 0.5730493338695 0.291128367708112 no 979 0.283305645570077 291 6498326 SGTC_164 4100-3994 89.624 µM 0.571518985594903 0.291617528782093 no 980 0.283823947236505 336 4615967 SGTC_3060 1327-0027 12.5 µM 0.564398198926579 0.293898643432777 no 981 0.286241582166795 292 16000455 YPR107C YTH1 SGTC_2439 5492030 7.2 µM 0.562621511763209 0.294469081646678 no 982 0.286846320261828 307 5722370 SGTC_2400 5203494 178.7 µM 0.561059545351353 0.294971001523564 no 983 0.287378472619179 326 6777674 SGTC_249 wiskostatin 11.211 µM 0.560247043975963 0.295232245216615 no 984 0.287655471370003 309 2775510 A n-wasp and actin depolymerizer. SGTC_489 paxilline 115 µM 0.559365661713261 0.295515756562474 no 985 0.287956095665209 314 105008 A toxic potassium channel blocker. SGTC_1414 3917-0015 5.4 µM 0.558486354739222 0.295798725048399 no 986 0.28825615984098 328 6618702 SGTC_2664 lyso-paf C-16 73.48 µM 0.557665551302151 0.296062978868108 no 987 0.288536392651733 327 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3007 9078383 71.4286 µM 0.557297353361079 0.296181553661669 no 988 0.288662141840143 314 6496995 SGTC_430 0958-0115 16.4 µM 0.557229195730067 0.296203505595509 no 989 0.288685422277599 329 6833180 SGTC_2605 digitonin 300 nM 0.556149025259638 0.296551502123027 no 990 0.289054491492617 323 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_606 k015-0008 38.6 µM 0.555374371708706 0.296801186106296 no 991 0.289319309232442 335 1970475 SGTC_222 nsc-310342 10.666 µM 0.553664815683182 0.297352545243146 no 992 0.289904129388344 337 432556 SGTC_3044 9093193 49.47 µM 0.553079439305722 0.297541445962489 no 993 0.290104507496353 324 25236277 SGTC_874 0599-0792 117 µM 0.551480859626098 0.29805758584872 no 994 0.290652042024495 327 765305 SGTC_1693 xanthone 101.9 µM 0.550443211717573 0.298392833634307 no 995 0.291007708582654 340 7020 An insecticide. SGTC_1854 st056233 32.9 µM 0.547272286084118 0.299418371964577 no 996 0.292095840406797 324 5393174 SGTC_1244 0416-0015 52.5 µM 0.546759196685838 0.299584465055917 no 997 0.292272089525971 327 96201 SGTC_2255 7941087 197.44 µM 0.544956917130882 0.300168214829211 no 998 0.292891574486946 329 935561 SGTC_1209 2323-2347 50.3 µM 0.543367915659753 0.300683311077786 no 999 0.293438255851076 316 5412760 SGTC_1791 st048313 56.1 µM 0.541633947322593 0.301245855033112 no 1000 0.294035350502084 313 1204976 SGTC_178 4092-0806 87.505 µM 0.540780252536907 0.301522989622445 no 1001 0.294329527793882 306 2169044 SGTC_269 exalamide 29 µM 0.5401207221562 0.301737171212648 no 1002 0.294556890399976 318 3316 A derivative of salicylamide. SGTC_3272 9137413 49.47 µM 0.539633629313727 0.301895397846694 no 1003 0.294724859918216 330 17614870 SGTC_465 cgp-37157 41 µM 0.538929131882482 0.302124311846228 no 1004 0.294967877533968 322 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1107 amlodipine 47 µM 0.538714347820914 0.302194117631325 no 1005 0.295041986030619 298 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2742 clothiapine 36.27 µM 0.536786141891061 0.302821117138837 no 1006 0.295707672620032 324 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3290 9121031 71.43 µM 0.535698852770135 0.303174930293151 no 1007 0.296083348314349 320 17014854 SGTC_2418 pentamidine 31.67 µM 0.53516111277254 0.303349983770984 no 1008 0.296269226955248 314 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1065 prochlorperazine maleate 2.48 µM 0.535029288535931 0.30339290413741 no 1009 0.296314802329115 335 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_957 1187-1561 14.1 µM 0.534861285753076 0.303447607730324 no 1010 0.296372890310389 309 1538454 SGTC_412 gemfibrozil 100 µM 0.532969387235064 0.304063935071872 no 1011 0.297027385789322 315 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1247 0448-0043 5.84 µM 0.531166488619286 0.304651787371984 no 1012 0.297651706512131 346 3089013 YGL099W LSG1 SGTC_1048 3161-0300 24.5 µM 0.530845540739787 0.304756488465849 no 1013 0.297762909417699 312 2165101 SGTC_2195 6536160 144.242 µM 0.530644380575172 0.304822120014049 no 1014 0.297832617605896 318 3834386 SGTC_2350 9023895 38.85 µM 0.529173567005961 0.305302185947312 no 1015 0.298342525758638 331 2997209 SGTC_635 k038-0028 24.7 µM 0.528656876794937 0.305470910532083 no 1016 0.29852174848124 351 4035102 SGTC_871 0574-0004 149 µM 0.527527613642241 0.305839813922392 no 1017 0.298913622865649 327 9551173 SGTC_955 1216-0110 33 µM 0.526783691764109 0.306082943203549 no 1018 0.299171904587893 338 3619719 SGTC_1139 k015-0024 46.9 µM 0.52560115902935 0.306469595560418 no 1019 0.299582675633671 330 2766652 SGTC_969 1313-0238 134 µM 0.523974739172206 0.307001737618832 no 1020 0.300148054837179 336 5212874 SGTC_2734 clemastine 41.6 µM 0.523830781251442 0.307048858271251 no 1021 0.300198121003401 357 26987 Clemastine is a selective histamine H1 antagonist. SGTC_545 4218-0007 221 µM 0.522814910898616 0.307381465956011 no 1022 0.300551531071763 341 2840508 SGTC_1148 3909-7663 27.7 µM 0.52070635015447 0.308072338697787 no 1023 0.301285675028801 345 4084526 SGTC_2834 9001755 58.44 µM 0.519831551743086 0.308359167488556 no 1024 0.301590493074072 356 2989575 SGTC_1357 1503-1303 39.5 µM 0.519800181505124 0.308369455332706 no 1025 0.30160142641375 304 292895 SGTC_2123 5259487 200 µM 0.51971542941883 0.308397250463317 no 1026 0.301630965600356 323 2173474 SGTC_2090 5301565 104.445 µM 0.519529951946677 0.308458083128865 no 1027 0.301695615789196 341 2056344 SGTC_2713 st079149 53.4 µM 0.518464454525254 0.308807645457622 no 1028 0.30206712713909 325 3103253 SGTC_2589 lobaric acid 100 µM 0.515872899297423 0.309658590955863 no 1029 0.302971591579666 329 73157 A novel microtubule depolymerizer. SGTC_1872 amphotericin b 148 nM 0.513989278562558 0.310277725106466 no 1030 0.303629743292522 338 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1427 4048-4900 550 nM 0.511342391951745 0.311148649023635 no 1031 0.30455566296743 343 24132586 SGTC_1607 st000305 50.6 µM 0.509381392620453 0.311794573512753 no 1032 0.305242458210615 351 5457690 SGTC_1732 st034308 51.822 µM 0.508906571812076 0.311951059741245 no 1033 0.305408856650036 315 830119 SGTC_3277 9138724 49.47 µM 0.508560676915968 0.312065077358067 no 1034 0.305530099004669 322 15943418 SGTC_2032 5185112 25.99 µM 0.508296722134995 0.31215209710202 no 1035 0.305622634231042 311 5718189 SGTC_587 k089-0003 57 µM 0.506840277238472 0.312632441443084 no 1036 0.306133446556267 342 9659696 SGTC_2491 paeonol 100 µM 0.50679311368175 0.31264800159646 no 1037 0.30614999432671 340 11092 Increases levels of cortical cytochrome oxidase. SGTC_3140 9094243 49.47 µM 0.506504973051997 0.312743071915411 no 1038 0.306251099722595 367 19291112 SGTC_2861 9024595 19.48 µM 0.505519975044016 0.313068160316308 no 1039 0.306596836160142 316 16482810 SGTC_1527 coumarin 137 µM 0.503578891654504 0.313709220143094 no 1040 0.307278664434363 379 323 A hepatotoxic, DNA x-linker. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.502896986062269 0.313934559159155 no 1041 0.307518350129443 341 229346 A bile salt which induces apoptosis. SGTC_441 propafenone 146 µM 0.501264474921846 0.314474312256762 no 1042 0.308092501767398 348 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2073 5212005 126 µM 0.497697200810718 0.315655130969156 no 1043 0.309348740677469 373 691789 SGTC_1852 st056254 31.4 µM 0.494952702081521 0.316564882728399 no 1044 0.310316753880329 344 442583 SGTC_1384 3089-0840 101 µM 0.492768954073807 0.317289549746336 no 1045 0.311087924778592 314 1069836 SGTC_2970 9090938 41.86 µM 0.492624630945849 0.317337467456985 no 1046 0.311138920469202 350 17217104 SGTC_175 3793-3120 23.7 µM 0.491895829661183 0.317579488520444 no 1047 0.311396493293136 362 5322297 SGTC_185 k048-0037 25.491 µM 0.489090791844722 0.318511715271373 no 1048 0.312388710134567 330 6827589 SGTC_2790 5423970 71.43 µM 0.48814284771649 0.318827015501582 no 1049 0.31272433155642 347 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_3085 9117376 49.47 µM 0.486377507951365 0.319414543095751 no 1050 0.313349767289437 342 16480349 SGTC_2334 9017922 200 µM 0.486090496880603 0.319510106954945 no 1051 0.313451502198629 350 3163164 SGTC_3231 9132313 49.47 µM 0.485711688422579 0.319636254232724 no 1052 0.31358579764759 346 4905967 SGTC_1647 st011722 22.4 µM 0.485055021154196 0.319854980914309 no 1053 0.313818658343209 332 2854783 SGTC_1935 st074532 41.6 µM 0.484510321058854 0.320036460439035 no 1054 0.314011870665103 364 2829742 SGTC_1700 st030840 7.9285 µM 0.483038990529389 0.320526883682088 no 1055 0.314534025849278 365 5499307 SGTC_875 0709-0210 25.7 µM 0.482934177830149 0.320561831776995 no 1056 0.314571236624903 343 6251364 SGTC_2035 5154463 94.595 µM 0.481434489818954 0.321062052529639 no 1057 0.31510386444254 389 2769623 SGTC_1138 3761-0006 1.03 µM 0.481228311970968 0.321130848549659 no 1058 0.315177120478211 338 12061087 SGTC_561 1550-0330 72.9 µM 0.481109199381124 0.321170596025506 no 1059 0.315219445098624 351 6812934 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.477649231393383 0.322326068387315 no 1060 0.31644994216096 325 115019 SGTC_351 caspofungin 25 nM 0.476889832987537 0.322579903418432 no 1061 0.316720286072152 341 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3216 9129716 49.47 µM 0.47669997502564 0.322643377900293 no 1062 0.316787890332166 316 8056934 SGTC_278 4092-0821 23.9 µM 0.476279001405999 0.322784138825191 no 1063 0.316937811636017 337 877900 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.475880509845416 0.322917405822872 no 1064 0.317079754103207 359 5282309 SGTC_1948 st076329 66.6 µM 0.475277454256813 0.323119128137334 no 1065 0.317294613350546 349 24208413 SGTC_968 1309-0633 340 µM 0.475067979264916 0.323189209776773 no 1066 0.317369260420429 350 3761976 SGTC_9 0092-0002 10.449 µM 0.474147370966571 0.323497281479188 no 1067 0.317697410105826 356 759368 SGTC_2074 5212007 75.395 µM 0.474060658398196 0.323526305150921 no 1068 0.317728326079429 352 758611 SGTC_2701 st077767 14.721 µM 0.473820858190277 0.323606574566772 no 1069 0.317813829608724 349 5721188 SGTC_2628 lathosterol 100 µM 0.467090718263789 0.325862721055654 no 1070 0.320217487282121 334 6710616 SGTC_2796 7949634 45.45 µM 0.466845593041579 0.325945015570548 no 1071 0.320305176682225 350 2971588 SGTC_687 k029-0044 34.9 µM 0.466456715811143 0.326075588536035 no 1072 0.320444311517753 364 5829338 SGTC_2661 dactinomycin 12.96 µM 0.466154513023054 0.326177073628303 no 1073 0.320552452879527 339 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2773 thioridazine 9.09 µM 0.465358520184478 0.326444443832357 no 1074 0.320837366790759 352 5452 An antipsychotic. SGTC_659 k018-0002 107 µM 0.464996717238185 0.326566001212091 no 1075 0.320966903728035 359 6797879 YHR007C ERG11 SGTC_143 4032-1194 15.74 µM 0.464703112667454 0.326664659060504 no 1076 0.321072039502688 342 1806963 SGTC_2752 diclazuril 33.15 µM 0.464405597518616 0.326764643318387 no 1077 0.321178590235232 360 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2017 5132927 60.65 µM 0.459770398310183 0.328323971890396 no 1078 0.322840516418564 347 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1522 st012842 45.6 µM 0.459423191676001 0.328440896694069 no 1079 0.322965148611858 355 3491067 YOR116C RPO31 SGTC_1629 st005085 44.9 µM 0.458844548686543 0.328635797003886 no 1080 0.323172900638584 345 24207091 SGTC_1565 sinapyl alcohol 95.1 µM 0.457419035313073 0.329116141629294 no 1081 0.323684942468309 368 5280507 A phenol propionate derived from cinnamic acid. SGTC_3043 9092303 49.47 µM 0.456997682906017 0.329258175695845 no 1082 0.323836355479131 327 25236084 SGTC_2190 6049624 200 µM 0.455764508020118 0.329674009297366 no 1083 0.324279664413289 360 2265554 SGTC_202 3594-0513 34.79 µM 0.452617105401516 0.33073628536453 no 1084 0.325412239685743 346 708429 SGTC_1782 st039423 80.636 µM 0.45204677265772 0.330928923976495 no 1085 0.325617643797592 351 2068169 SGTC_2532 xanthone 78.9 µM 0.45041572882599 0.331480080963444 no 1086 0.32620535286028 357 7020 An insecticide. SGTC_3250 9135583 49.47 µM 0.45037708622523 0.331493143376785 no 1087 0.326219282073696 336 7699353 SGTC_3210 9128157 49.47 µM 0.44928173110109 0.33186349302159 no 1088 0.326614217424409 362 17590849 SGTC_2492 derrusnin 100 µM 0.446868699587858 0.332679940624843 no 1089 0.327484932411955 397 1715307 Part of coumarin class of compounds. SGTC_644 1498-1197 63.3 µM 0.444815288501575 0.333375336611584 no 1090 0.328226622450472 354 6741615 SGTC_3101 9120531 49.47 µM 0.444596064614163 0.33344961156697 no 1091 0.328305845985994 393 24824904 SGTC_1086 cerivastatin 2.18 µM 0.443439062556808 0.333841722021959 no 1092 0.328724093388308 337 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_546 peri-Naphthalide 147 µM 0.443076650566788 0.333964581566723 no 1093 0.328855146720636 338 223824 A penicillin ester. SGTC_1271 0832-2808 169 µM 0.442585478338299 0.334131119905282 no 1094 0.329032795174656 377 3663794 SGTC_1793 st048256 72.231 µM 0.441896123183038 0.334364909830718 no 1095 0.329282188081252 371 672022 SGTC_2533 agelasine 13.65 µM 0.441501891267449 0.334498639685403 no 1096 0.329424846316932 370 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1505 k297-0037 20.6 µM 0.441414548247493 0.334528270695769 no 1097 0.329456455949781 343 4089396 SGTC_2840 9008771 71.43 µM 0.439237586181897 0.335267134947038 no 1098 0.330244696587363 324 2992978 SGTC_530 4358-1714 28 µM 0.438698248668501 0.335450285605007 no 1099 0.330440098123307 368 1564641 SGTC_3116 9124943 49.47 µM 0.438428855348549 0.335541782049174 no 1100 0.330537716419557 329 41905195 YPL160W CDC60 SGTC_2080 5212524 12.4 µM 0.437335673736051 0.335913169064225 no 1101 0.330933963763336 367 260183 SGTC_1272 0839-0021 27 µM 0.437123672639794 0.335985210845639 no 1102 0.331010830099342 393 5027250 SGTC_268 camptothecin 39.6153 µM 0.436545452295238 0.336181731131739 no 1103 0.33122051464819 359 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_205 1486-1330 71.903 µM 0.436126933560832 0.336324001421824 no 1104 0.331372318384616 364 4118834 SGTC_2915 7971052 15.16 µM 0.433634042117289 0.337171914236592 no 1105 0.332277105130064 355 5741558 SGTC_3122 9126309 49.47 µM 0.433362642981832 0.337264275883035 no 1106 0.332375667704478 418 17591206 SGTC_810 3825-7150 143 µM 0.433226982270411 0.337310447159887 no 1107 0.332424939226547 343 22330411 YGL099W LSG1 SGTC_1364 1653-0028 37.6 µM 0.432811919735598 0.337451726317546 no 1108 0.332575706548425 347 5718652 SGTC_1398 3558-0053 112 µM 0.432662534106605 0.337502579869323 no 1109 0.332629976016623 374 4532369 SGTC_1240 0356-0016 42.1 µM 0.432037348890359 0.337715436339765 no 1110 0.332857134098133 348 4305613 SGTC_779 1360-0071 233 µM 0.431467876338432 0.337909369538602 no 1111 0.333064102654783 358 7566 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.431434233688127 0.337920827849794 no 1112 0.333076331298881 367 756377 SGTC_1561 5-methoxyflavone 52.9 µM 0.431365414618659 0.337944267324553 no 1113 0.333101346644005 369 94525 SGTC_2524 avocatin b 10.57 µM 0.429951787748487 0.338425881373632 no 1114 0.333615356228798 353 6710748 SGTC_1403 3909-7815 62.9 µM 0.429106937464906 0.338713843003531 no 1115 0.333922701918239 365 6615483 SGTC_2027 5150920 200 µM 0.427971552283606 0.33910098003463 no 1116 0.334335915960101 383 786715 SGTC_2715 st079500 56.4 µM 0.427619720458327 0.339220980113885 no 1117 0.334464003021728 355 28246688 SGTC_1635 st007035 42.4 µM 0.42693641590556 0.339454082937087 no 1118 0.334712820309183 347 3716403 SGTC_2720 fluspirilene 36.88 µM 0.425671673638795 0.339885699733259 no 1119 0.335173552748091 365 3396 An atypical antipsychotic. SGTC_1185 1319-0113 81.3 µM 0.422738946316569 0.340887354620635 no 1120 0.336242868454517 379 4672763 SGTC_1729 st035615 45.989 µM 0.422279217321789 0.341044474186542 no 1121 0.33641061290136 352 17385451 SGTC_1265 0819-1001 68.8 µM 0.421580825664428 0.341283213191758 no 1122 0.336665502126018 405 3106768 SGTC_71 0417-1750 47.813 µM 0.416864400072253 0.342897140795935 no 1123 0.338388797074805 326 6811472 SGTC_3293 9120939 62.045 µM 0.416464660853238 0.343034061123162 no 1124 0.33853501076423 386 934087 SGTC_2323 6148992 148.28 µM 0.41507753960417 0.343509343392708 no 1125 0.339042570510843 352 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1306 1185-0270 9.02 µM 0.412480408220651 0.344399887841808 no 1126 0.339993668899332 391 1548076 SGTC_460 trequinsin 123 µM 0.411906548040361 0.34459677849247 no 1127 0.340203960575675 375 5537 A vasodilator. SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.411154387109735 0.344854907648127 no 1128 0.340479666026554 344 66535 A nucleotide analog. SGTC_2246 7293507 91.5585 µM 0.409765732674642 0.34533166052437 no 1129 0.340988902857247 375 887656 SGTC_825 1988-2224 89.6 µM 0.408232844088172 0.345858216966347 no 1130 0.341551368681727 361 1180859 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.407918425834181 0.34596625842279 no 1131 0.341666782341972 342 6857784 SGTC_2746 daunorubicin 9.88 µM 0.407889876125523 0.345976069390803 no 1132 0.341677262830573 371 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1826 st055655 41.6 µM 0.407846859391487 0.345990852076736 no 1133 0.341693054339212 369 676168 SGTC_161 4065-0411 162.148 µM 0.407528307844698 0.346100329510599 no 1134 0.341810003718395 381 1906281 YLR208W SEC13 SGTC_1856 st057054 55.7 µM 0.406828558636868 0.346340859284028 no 1135 0.342066954950321 388 1266018 SGTC_1736 st036774 51 µM 0.406094433752125 0.346593271880524 no 1136 0.342336607730202 387 1272247 SGTC_818 4072-2707 53.5 µM 0.404258074452153 0.347224961515168 no 1137 0.343011476124259 365 882871 SGTC_612 0302-0167 22.4 µM 0.402395865613134 0.347865976852933 no 1138 0.343696356119455 388 235821 SGTC_1430 4049-0248 69.1 µM 0.401426796979744 0.348199724916525 no 1139 0.344052961756603 391 22774488 SGTC_2983 9022671 12.99 µM 0.397952179610489 0.349397351232828 no 1140 0.34533271792197 405 6405161 SGTC_598 3937-0236 20.2 µM 0.39794963390297 0.349398229235425 no 1141 0.345333656196797 387 1379313 SGTC_2913 7966556 36.57 µM 0.397820848516128 0.349442647763505 no 1142 0.345381124039434 389 2976516 SGTC_3139 9095020 49.47 µM 0.395020853944616 0.350408884419055 no 1143 0.346413748853926 359 25236292 SGTC_2854 9024559 71.43 µM 0.394759674905448 0.350499062932613 no 1144 0.346510128828741 373 3163529 SGTC_1756 st041558 35.5 µM 0.393982811608146 0.35076734396313 no 1145 0.346796864706404 388 3955792 SGTC_750 4073-0104 132 µM 0.393731824580931 0.350854035433495 no 1146 0.346889521374825 366 22330957 SGTC_674 0498-0004 451 µM 0.392531282250865 0.351268812725141 no 1147 0.34733285113922 364 4231473 SGTC_3275 9138069 49.47 µM 0.391741321729926 0.351541834150776 no 1148 0.347624677501551 407 17617007 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.390443080737411 0.3519906907692 no 1149 0.348104468407747 393 551469 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.39001535345078 0.352138619333732 no 1150 0.348262596885213 378 6708784 An antioxidant flavonoid SGTC_461 N-acetylfarnesylcysteine 136 µM 0.389799983987426 0.352213112872426 no 1151 0.348342227805051 401 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_971 1315-0384 26.7 µM 0.388376842437113 0.352705501729698 no 1152 0.348868589476541 394 6769120 SGTC_246 cycloheximide 667 µM 0.386358631658636 0.35340420008479 no 1153 0.349615541595537 388 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2655 perillic acid 100 µM 0.385673856458215 0.353641379583393 no 1154 0.3498691135913 380 5702197 An apoptosis inducer. SGTC_537 1334-0398 209 µM 0.385653425151555 0.35364845706698 no 1155 0.349876680325868 385 5846986 SGTC_717 1532-0246 73.2 µM 0.385458323163434 0.353716043697449 no 1156 0.349948939351197 348 9561992 SGTC_2788 5282734 71.43 µM 0.384373498261436 0.354091929451066 no 1157 0.350350820006896 392 743706 SGTC_2333 9017922 200 µM 0.384243153165852 0.354137102874912 no 1158 0.350399118508441 380 3163164 SGTC_1355 1499-0035 1.68 µM 0.383946938352668 0.354239769048184 no 1159 0.350508887916258 381 1548538 SGTC_2707 st078556 66.6 µM 0.382730861221219 0.354661364620327 no 1160 0.350959664821015 370 17250899 SGTC_1963 st076565 50.3 µM 0.382461823440171 0.354754660031476 no 1161 0.351059420431871 393 4914280 SGTC_2583 asiatic acid 100 µM 0.381196043218869 0.355193717025372 no 1162 0.351528892464929 405 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1318 1280-3875 124 µM 0.380602106102251 0.355399800352064 no 1163 0.351749259137214 390 373245 SGTC_1689 st020265 53.493 µM 0.380312187010362 0.355500411366256 no 1164 0.351856845030322 395 5758320 YPR016C TIF6 SGTC_2570 licareol 100 µM 0.378407597020117 0.356161613887195 no 1165 0.352563912724464 371 443158 SGTC_917 harmaline 728.087 nM 0.378002307632407 0.356302371136669 no 1166 0.352714439852015 354 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2726 cimetidine 79.27 µM 0.377713295072904 0.356402757334463 no 1167 0.352821795093627 406 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2905 7799065 20.05 µM 0.377561707226007 0.356455414137742 no 1168 0.352878107886108 397 1296806 SGTC_1836 st055642 81 µM 0.376929312137183 0.356675117617055 no 1169 0.353113068689131 412 8571 SGTC_740 k014-0057 261 µM 0.375090135419721 0.357314345080935 no 1170 0.35379671657881 417 4012779 SGTC_1093 fluphenazine 7.97 µM 0.373658801755112 0.357812099219973 no 1171 0.354329090016294 400 6602611 An atypical antipsychotic. SGTC_702 1488-0190 94 µM 0.373343640573069 0.357921730772743 no 1172 0.354446350061741 377 949357 SGTC_3096 9117468 49.47 µM 0.372077536031269 0.358362274253857 no 1173 0.354917560598542 384 41316311 SGTC_2944 9067346 25.62 µM 0.371298124540606 0.358633565787064 no 1174 0.35520774734213 386 6473075 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.370875590008589 0.358780668177056 no 1175 0.355365098488444 393 279621 SGTC_2894 9048625 32.47 µM 0.370373433770309 0.358955517538866 no 1176 0.355552132690014 425 4092861 SGTC_1267 0828-0272 9.49 µM 0.3700137758982 0.359080767545253 no 1177 0.355686113024811 379 745334 SGTC_1445 4239-0156 97.7 µM 0.368920846464665 0.359461470558156 no 1178 0.35609336223199 416 4008346 SGTC_862 0452-0056 10.2 µM 0.368905561984344 0.359466795632027 no 1179 0.356099058726265 377 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2809 7964133 12.99 µM 0.368367853992165 0.359654149083724 no 1180 0.356299481818341 408 1253665 SGTC_231 b-estradiol 524 µM 0.366293751629897 0.360377143690322 no 1181 0.357072945793376 366 450 A steroid. SGTC_1513 0337-0559 19 µM 0.364460284877744 0.361016673164151 no 1182 0.3577571627234 375 775073 SGTC_3313 9133968 57.047 µM 0.364152919123109 0.361123923161209 no 1183 0.357871910931701 406 1494643 SGTC_291 SEC14.278 35.5 µM 0.361960187611298 0.361889355453517 no 1184 0.358690890858117 384 1068044 SGTC_1395 3486-0190 4.35 µM 0.36115523983015 0.362170483145964 no 1185 0.358991700263753 400 6748079 SGTC_1620 st003704 16.5 µM 0.360920726503772 0.362252400827182 no 1186 0.35907935447596 381 2834414 SGTC_742 0kpi-0133 140 µM 0.359375282353925 0.362792396426963 no 1187 0.359657181588853 413 2728852 SGTC_2571 chrysanthemic acid 100 µM 0.359075950828959 0.362897017823579 no 1188 0.359769135992716 398 2743 An insecticide. SGTC_367 0335-0881 7.1 µM 0.357600742137674 0.363412777412774 no 1189 0.360321061422877 407 23828853 SGTC_1564 D-Arginine 115 µM 0.355778833140415 0.364050091481474 no 1190 0.361003100990864 390 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3144 9087057 49.47 µM 0.35449442596883 0.364499610573048 no 1191 0.361484190306234 425 17249618 SGTC_2650 prasterone 100 µM 0.354383693023649 0.364538373821462 no 1192 0.361525676859046 383 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1085 doxorubicin 7.67 µM 0.353413393965788 0.364878096562843 no 1193 0.361889272972796 410 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3220 9131269 49.47 µM 0.352921938597863 0.365050206244526 no 1194 0.362073481586464 401 17722206 SGTC_407 eburnamonine 100 µM 0.351469655233703 0.365558960598998 no 1195 0.362618016892164 373 3195 SGTC_2990 9074105 71.4286 µM 0.350090436461268 0.36604233852269 no 1196 0.363135413952396 425 6502001 SGTC_113 0099-0221 2.5 µM 0.345954034222059 0.367493305516784 no 1197 0.364688629746785 424 89219 SGTC_1977 st070720 65.3 µM 0.345715433153603 0.367577059953221 no 1198 0.364778292336396 375 682188 SGTC_935 2996-0153 430 µM 0.345464750375432 0.367665062131563 no 1199 0.364872503013156 401 23738523 SGTC_496 calpeptin 138 µM 0.345327582280781 0.367713217926765 no 1200 0.36492405647443 379 73364 A calpain inhibitor. SGTC_378 3970-0959 8.33 µM 0.344305325220259 0.368072168603613 no 1201 0.365308339951244 405 6615653 SGTC_3326 9140064 16.379 µM 0.341404390765319 0.36909141594889 no 1202 0.366399585055148 388 1868434 SGTC_1664 st014217 9.02 µM 0.340958474899086 0.369248170963317 no 1203 0.366567421400181 414 3982782 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.340432121522113 0.369433230553992 no 1204 0.366765566109716 406 1241132 A phosphatase inhibitor. SGTC_1227 3909-8010 46.6 µM 0.339388239914201 0.369800336386608 no 1205 0.367158638313954 399 15982272 SGTC_914 3820-6779 408 µM 0.338994993485002 0.369938661657175 no 1206 0.367306750862268 364 2893481 SGTC_2745 rifampicin 24.3 µM 0.337859207976028 0.370338271067039 no 1207 0.367734644535151 406 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_51 1013-0126 23.419 µM 0.337262719758638 0.370548192751574 no 1208 0.367959430175816 420 1627850 SGTC_592 k241-0073 46.5 µM 0.336883949309062 0.370681513188926 no 1209 0.368102192701847 404 4230158 SGTC_2879 9041815 71.43 µM 0.335567656961668 0.371144945264812 no 1210 0.368598458537985 390 4942971 SGTC_128 0906-2981 13.371 µM 0.335073564240716 0.371318950663056 no 1211 0.368784796997632 395 6740226 SGTC_946 3434-1334 87.4 µM 0.331308791302415 0.372645658028553 no 1212 0.370205625725003 392 4047976 SGTC_1021 4476-0760 85.3 µM 0.331062880733418 0.372732369791053 no 1213 0.370298494489743 389 746768 SGTC_3262 9137218 49.47 µM 0.330934921526618 0.372777492682009 no 1214 0.370346821607442 380 17650664 SGTC_2047 4141938 200 µM 0.329988824270512 0.373111173793468 no 1215 0.370704203265293 430 3807862 SGTC_1120 ficusin 1.78878 µM 0.329275957519958 0.373362659233528 no 1216 0.370973557456294 405 6199 A DNA cross-linker. SGTC_1993 st073995 70.8 µM 0.329268237254564 0.373365383087577 no 1217 0.370976474877714 395 3098394 SGTC_3354 9151612 71.43 µM 0.328116337774646 0.373771865607875 no 1218 0.371411850730742 421 27261949 SGTC_452 diindolylmethane 8 µM 0.326549436769098 0.374325019332035 no 1219 0.372004346084823 428 3071 Inhibits expression of several cancer promoting factors. SGTC_3 0833-0587 95.581 µM 0.326458004639929 0.37435730507398 no 1220 0.37203892887159 385 5382644 SGTC_803 4488-1585 147 µM 0.326241596218335 0.374433724899979 no 1221 0.372120786117938 427 747204 SGTC_1287 0971-0001 34.6 µM 0.323715701934267 0.375326052423321 no 1222 0.373076641013616 374 4665869 SGTC_2476 5806916 10.51 µM 0.322119227865445 0.375890386487249 no 1223 0.373681186127052 422 2870194 SGTC_800 3448-7362 155 µM 0.319708329276128 0.376743112641803 no 1224 0.374594722542376 407 15991913 SGTC_1045 1348-1485 165 µM 0.319576779817848 0.376789658560176 no 1225 0.374644589503129 383 6810614 SGTC_984 1492-0255 2.91 µM 0.319460223112234 0.376830901115143 no 1226 0.374688774854974 413 1585198 SGTC_1035 k081-0041 55.2 µM 0.319420412727324 0.376844987988276 no 1227 0.374703866906467 434 731709 SGTC_1446 4239-0190 62 µM 0.316205309790269 0.377983189377177 no 1228 0.375923338868599 412 1340085 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.314252460625619 0.378675049470121 no 1229 0.376664650723741 382 16623 A steroid. SGTC_136 0097-0015 404.482 µM 0.314244735281389 0.378677787197569 no 1230 0.376667584210566 378 4861337 SGTC_1676 st018489 23.4 µM 0.313074264999555 0.379092651746504 no 1231 0.377112120268392 416 3696235 SGTC_1425 4048-4433 7.33 µM 0.313061134696967 0.379097306476307 no 1232 0.377117107986479 447 23734946 SGTC_2493 resveratrol 26.09 µM 0.312715928799301 0.379219689241126 no 1233 0.377248246338672 385 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_964 1287-0107 19.4 µM 0.311939607493063 0.379494955709784 no 1234 0.377543210427362 422 51516812 YPR165W RHO1 SGTC_38 0929-0051 58.268 µM 0.311796783999811 0.379545604438346 no 1235 0.377597484147542 427 1379719 SGTC_2843 9000894 45.46 µM 0.310853758851936 0.379880076226104 no 1236 0.377955899555541 367 2242070 SGTC_1723 st034307 2.5525 µM 0.310741198901194 0.379920004953972 no 1237 0.377998687222465 392 867466 SGTC_3285 9112818 20.8695 µM 0.310118914008677 0.380140773024897 no 1238 0.378235264771403 423 17017947 YPR165W RHO1 SGTC_158 k038-0087 26.446 µM 0.30990819360945 0.380215539176816 no 1239 0.378315385883888 396 X158 SGTC_2584 androsterone 48.74 µM 0.309842476271022 0.380238857400859 no 1240 0.378340374313412 387 2754130 A steroid. SGTC_691 1548-0686 185 µM 0.309398304561295 0.380396472506014 no 1241 0.378509279965535 422 46495133 SGTC_94 0334-0113 514.748 µM 0.3081979733003 0.380822511426813 no 1242 0.378965847265744 435 6795178 SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.307644593758481 0.381018973603382 no 1243 0.379176391926415 411 6708630 An antioxidant. SGTC_2708 st078559 56 µM 0.30573521729377 0.381697080390441 no 1244 0.379903128445428 412 17250902 SGTC_2148 5546263 113.568 µM 0.303006719644491 0.382666724456651 no 1245 0.380942370327944 396 792097 SGTC_1429 4049-0205 9.46 µM 0.300832081992883 0.383440067051241 no 1246 0.38177127151949 393 22774478 SGTC_426 0988-0037 14.6 µM 0.299991388790745 0.383739158275972 no 1247 0.382091862025576 442 5383008 SGTC_2436 5633522 8.09 µM 0.299677010840938 0.383851021504248 no 1248 0.382211767906961 404 5724242 SGTC_769 0302-0231 76 µM 0.299555095952985 0.383894404355733 no 1249 0.382258270112297 423 571869 YER009W NTF2 SGTC_1037 k284-1091 78.7 µM 0.297238523917751 0.384719021775012 no 1250 0.383142206177832 419 3334711 SGTC_729 4092-0585 94.1 µM 0.295362365327516 0.385387250276772 no 1251 0.383858539805332 383 2169061 SGTC_276 colchicine 750 µM 0.294423481117694 0.385721779137168 no 1252 0.384217163155753 438 2833 A microtubule depolymerizer. SGTC_2266 7929956 200 µM 0.294263494718273 0.385778791528312 no 1253 0.384278282671961 399 2967153 SGTC_2237 6667747 47.222 µM 0.290935261862263 0.386965390916532 no 1254 0.385550416074895 447 729940 YDL015C TSC13 SGTC_1770 st043884 66.3 µM 0.290873638492523 0.386987371212751 no 1255 0.385573981720213 433 670149 SGTC_942 3253-1115 227 µM 0.290089052911323 0.387267254876316 no 1256 0.385874055204881 424 46497897 SGTC_211 3455-0679 143.504 µM 0.289257835178263 0.387563837475269 no 1257 0.386192038185784 401 748649 SGTC_661 1304-0007 33.6 µM 0.288997014710861 0.387656913042577 no 1258 0.386291831025713 421 3117130 SGTC_169 k015-0017 16.025 µM 0.288734819996704 0.387750485526649 no 1259 0.386392157249731 428 1840002 SGTC_1772 st048439 82.2 µM 0.288443542343511 0.387854444822179 no 1260 0.386503620679478 402 2927068 YDL195W SEC31 SGTC_1895 st058434 18.3 µM 0.288368805583547 0.387881120258445 no 1261 0.386532221759449 433 5393175 SGTC_2761 levamisole 97.89 µM 0.288261075888009 0.387919572637295 no 1262 0.38657345002114 421 26879 An alkaline phosphatase inhibitor. SGTC_1408 3909-7976 48.8 µM 0.288145710425201 0.387960751698864 no 1263 0.386617601918226 415 24152374 SGTC_1475 4092-1048 11.7 µM 0.287348847964468 0.388245221714435 no 1264 0.386922611834014 420 2881759 SGTC_698 k064-0052 127 µM 0.287001430788463 0.388369264117582 no 1265 0.38705561234577 442 5088751 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.284237561908206 0.389356485066396 no 1266 0.388114165887017 442 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2949 9072542 2.23 µM 0.282296445429581 0.390050256237226 no 1267 0.388858105462417 404 16457352 SGTC_230 MPP+ 141.667 µM 0.279393026630659 0.391088615636453 no 1268 0.389971611020447 420 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1944 st076371 56.9 µM 0.279314174400203 0.391116826692267 no 1269 0.390001864701048 439 24208455 SGTC_1919 st067113 52.3 µM 0.278597647576857 0.391373205580552 no 1270 0.390276809110595 415 1268243 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.277658846993656 0.391709187172732 no 1271 0.390637127068173 438 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_43 0570-0105 72.5 µM 0.273960272170883 0.393033631311847 no 1272 0.392057576106803 441 1114046 YDL195W SEC31 SGTC_3061 glucosamine 200 µM 0.271695707692518 0.393845175026119 no 1273 0.392928000977117 451 91431 and experimental redox chemotherapeutic SGTC_3128 9127691 49.47 µM 0.270224566771694 0.394372629810844 no 1274 0.393493746969409 440 41316314 SGTC_1451 4152-0210 104 µM 0.269472386451628 0.394642387326082 no 1275 0.393783094480802 438 659563 SGTC_1124 fisetin 1.16336 µM 0.269308197195295 0.39470127791564 no 1276 0.393846262343209 411 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2914 7968218 45.32 µM 0.268406670215844 0.395024675993799 no 1277 0.394193152869866 430 2977111 SGTC_2646 retinol 96.75 µM 0.268314551640153 0.39505772508306 no 1278 0.394228603086754 433 445354 A vitamin A analog and teratogen. SGTC_2296 7971656 126.45 µM 0.268115517963263 0.395129134341726 no 1279 0.394305200695116 421 666570 SGTC_2435 5706476 10.6 µM 0.267049348698278 0.395511714227822 no 1280 0.394715582772082 421 5725375 SGTC_2517 totarol 10 µM 0.26686278787722 0.395578669325568 no 1281 0.394787404424654 394 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2398 5228213 48.84 µM 0.266171732991897 0.395826709905379 no 1282 0.395053475898858 438 80771 YMR134W ERG29 SGTC_1680 diphenhydramine 100 µM 0.26602659380399 0.3958788101311 no 1283 0.395109363932062 445 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1997 st073024 93.8 µM 0.265743185275344 0.395980549893823 no 1284 0.395218500880061 456 686268 SGTC_2219 9098279 200 µM 0.263725885554292 0.396704937090837 no 1285 0.395995573840671 423 902349 SGTC_890 0929-0006 47.2 µM 0.263134579904314 0.396917335281912 no 1286 0.396223425948232 414 1378169 SGTC_2706 st078239 82.5 µM 0.262037345801882 0.397311544984232 no 1287 0.396646325026977 448 15434492 SGTC_2988 9073640 71.4286 µM 0.261664372649376 0.397445569140046 no 1288 0.396790105114893 438 9102229 SGTC_2721 ifenprodil 61.44 µM 0.26148006233505 0.397511803671212 no 1289 0.396861161397869 424 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2401 5128683 200 µM 0.261387639875985 0.397545018108069 no 1290 0.396896793880304 430 708373 SGTC_979 1426-2828 121 µM 0.260296840380278 0.397937081597906 no 1291 0.397317404819774 433 747872 SGTC_361 000s-0510 1.45 µM 0.260042085337732 0.398028662466084 no 1292 0.397415655272199 399 660 SGTC_100 0086-0128 49.5915 µM 0.259878899314047 0.398087328507474 no 1293 0.397478594054008 440 93297 SGTC_2104 5389443 200 µM 0.259652137077629 0.398168854281883 no 1294 0.397566057806865 426 2244536 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.259352051491536 0.39827674817033 no 1295 0.397681810795893 449 91467 include heat shock SGTC_1109 tnp00067 928.257 nM 0.258780345768029 0.398482322890774 no 1296 0.397902361627259 432 676295 SGTC_3200 9114385 49.47 µM 0.258608238710073 0.398544214900494 no 1297 0.397968762938931 399 17018030 YLR208W SEC13 SGTC_706 4262-0057 46.9 µM 0.258504351327717 0.398581575433753 no 1298 0.398008845575529 427 883298 SGTC_1132 3456-3614 2.5 µM 0.257086892112499 0.399091422380325 no 1299 0.398555848068644 407 3125502 SGTC_1369 1866-0067 208 µM 0.25694911434541 0.399140988962597 no 1300 0.398609027640915 422 3531355 SGTC_2714 st079313 56.9 µM 0.256760411168532 0.399208878980723 no 1301 0.398681866498342 423 2939799 SGTC_3284 9108171 64.8615 µM 0.256694955692708 0.399232428705291 no 1302 0.398707132939227 445 8687505 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.256157841813813 0.399425686639762 no 1303 0.398914480068879 459 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1034 k072-0165 12.7 µM 0.253910914248926 0.400234416126904 no 1304 0.399782191353936 446 5835461 SGTC_2299 7976368 114.88 µM 0.253817612336591 0.400268007265966 no 1305 0.399818233123756 411 2979718 SGTC_1899 st063254 59.6 µM 0.251849637683609 0.400976701361586 no 1306 0.400578644136027 432 3093813 SGTC_2185 6113692 200 µM 0.249372417484743 0.401869244806315 no 1307 0.401536359488083 429 874150 SGTC_2811 7967822 32.47 µM 0.249367469530928 0.401871028070024 no 1308 0.401538273005069 418 2232244 SGTC_1179 1021-1431 9.29 µM 0.248048177780539 0.402346579239571 no 1309 0.402048565421436 451 2840958 SGTC_1200 1643-0193 18.4 µM 0.245846939887608 0.403140357731723 no 1310 0.402900359570463 451 5403974 SGTC_2056 5235370 200 µM 0.244365578910089 0.40367476963537 no 1311 0.403473848919919 411 5511916 SGTC_2328 6201408 200 µM 0.244297430704749 0.403699358938908 no 1312 0.403500236602921 429 2890418 SGTC_2130 NSC 7 2.4545 µM 0.243368546417908 0.404034557807785 no 1313 0.403859953866596 448 21448 SGTC_1217 1183-1422 255 µM 0.242180381286068 0.404463423934621 no 1314 0.404320198049673 433 2849664 SGTC_2059 5238311 157 µM 0.239010325951047 0.405608210360449 no 1315 0.405548787906461 424 703021 SGTC_2380 9035439 200 µM 0.238624557211905 0.405747576449294 no 1316 0.405698360618729 425 6462575 SGTC_3113 9123498 49.47 µM 0.238510862180575 0.405788653161534 no 1317 0.405742445808368 454 8897275 SGTC_900 1112-0045 141 µM 0.236787899193007 0.406411266672311 no 1318 0.406410669837944 466 56211 YIL048W NEO1 SGTC_103 0844-0104 51.839 µM 0.236623831912031 0.406470566735754 no 1319 0.40647431499442 415 5375804 SGTC_1197 1601-0112 267 µM 0.235721813221573 0.406796628373272 no 1320 0.406824271149243 459 7350313 SGTC_961 1252-1571 372 µM 0.23261143276189 0.407921462673683 no 1321 0.408031574377314 461 6813498 SGTC_615 k087-0205 167 µM 0.232117065241746 0.40810031533472 no 1322 0.408223545334041 455 9642773 SGTC_829 1635-0120 117 µM 0.231277375922798 0.408404142647753 no 1323 0.408549660830751 427 285054 SGTC_849 0386-0493 241 µM 0.229201589015087 0.409155466839564 no 1324 0.409356118799464 439 726119 SGTC_2808 7946468 45.46 µM 0.228918843293063 0.409257831612446 no 1325 0.409465997293689 448 2970879 SGTC_1237 0330-0133 46.1 µM 0.228567476223258 0.40938504856168 no 1326 0.409602552804599 452 X1237 YHR072W ERG7 SGTC_2395 5646831 180.19 µM 0.22808778986509 0.409558740557901 no 1327 0.409788996104997 442 6808628 SGTC_228 caffeine 993.056 µM 0.227034555408953 0.409940173648298 no 1328 0.410198436166274 431 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_3316 9136639 10.545 µM 0.226437898209623 0.410156293294747 no 1329 0.410430427388902 457 4903665 SGTC_846 0335-0850 148 µM 0.226167669471612 0.410254183841122 no 1330 0.410535507578284 440 6819598 SGTC_997 3996-0078 137 µM 0.225476573239067 0.4105045593527 no 1331 0.410804274008257 435 735687 SGTC_804 1595-0054 20.9 µM 0.224753015693953 0.410766734278453 no 1332 0.411085709479866 437 761523 Stimulates phospholipase C. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.224424022408831 0.410885955391931 no 1333 0.411213690094165 429 23847180 SGTC_2288 7946289 167.31 µM 0.222953012876306 0.411419122730674 no 1334 0.411786038155734 449 1246052 SGTC_1051 3253-3903 78 µM 0.222212561493128 0.411687561275882 no 1335 0.412074207951204 465 5509239 SGTC_2807 7945238 51.95 µM 0.221943340914765 0.411785173050087 no 1336 0.412178995315321 465 17148797 SGTC_1167 k781-0610 148 µM 0.221744785744549 0.411857167042319 no 1337 0.412256281952275 431 4525169 SGTC_879 0831-1030 162 µM 0.221063269609896 0.412104300097643 no 1338 0.412521584669378 456 1549252 SGTC_735 3076-0345 636 µM 0.220482204840881 0.412315034768184 no 1339 0.412747814941065 456 2888990 SGTC_2147 5545932 89.7195 µM 0.22025172322727 0.412398630506206 no 1340 0.41283755809607 461 797404 SGTC_375 3970-0961 9.27 µM 0.220210812657329 0.412413469195429 no 1341 0.412853488014836 415 2898222 SGTC_3152 9099253 49.47 µM 0.219137078026006 0.412802968615112 no 1342 0.413271634268324 454 25236131 SGTC_1843 st055809 45.5 µM 0.218511839464375 0.413029814756762 no 1343 0.413515167316538 427 16413835 SGTC_3244 9134489 49.47 µM 0.217628235047968 0.413350449501301 no 1344 0.413859391669959 460 16584271 SGTC_2247 cerulenin 830 nM 0.21715786637683 0.413521156411264 no 1345 0.414042659453748 462 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_282 k297-0036 65.7 µM 0.215104611130146 0.414266517930521 no 1346 0.414842879446722 442 5061378 SGTC_2116 5511452 16.8835 µM 0.215047495551085 0.41428725614435 no 1347 0.41486514430403 461 870744 SGTC_836 0330-0104 1.35 µM 0.213544764022746 0.414832971730009 no 1348 0.415451038787685 402 46494820 SGTC_2099 5377090 177.372 µM 0.213492128096457 0.414852089404717 no 1349 0.415471564231929 437 2243829 SGTC_684 1140-0066 328 µM 0.213071258734962 0.415004958854629 no 1350 0.415635691048318 429 6813534 SGTC_515 4092-1064 102 µM 0.213001272395168 0.415030380754537 no 1351 0.415662985114391 470 717353 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.212723145545321 0.415131411312624 no 1352 0.415771456195918 423 16486 A toxic proline analog. SGTC_797 k781-0471 270 µM 0.21265814989442 0.415155022021078 no 1353 0.415796805801455 443 23738129 SGTC_621 3584-0052 32.1 µM 0.212448566483299 0.415231158629808 no 1354 0.415878549915187 464 2273927 SGTC_634 1611-4317 11.2 µM 0.21178564308109 0.415472003691649 no 1355 0.416137134813724 455 2843522 SGTC_2821 7996764 71.43 µM 0.211353110229945 0.415629163259715 no 1356 0.416305871417011 416 2987135 SGTC_2089 5281248 129.67 µM 0.211040807545034 0.415742645934559 no 1357 0.416427714284923 428 2737878 SGTC_2979 9012552 45.46 µM 0.208205037410556 0.416773411525863 no 1358 0.417534437747225 459 17100905 SGTC_3110 9122132 49.47 µM 0.208092081211447 0.416814481538321 no 1359 0.417578535052688 429 918317 SGTC_2235 salicylic acid 500 µM 0.207021104063135 0.417203925713578 no 1360 0.417996688425126 434 338 A COX inhibitor and kinase inhibitor. SGTC_442 cape 100 µM 0.206387482373456 0.417434370659426 no 1361 0.418244123986673 462 5281787 SGTC_32 0928-0142 34.1 µM 0.206346407820735 0.417449310242456 no 1362 0.418260165125246 463 2244242 SGTC_2002 4023503 131 µM 0.206021405437148 0.417567523887865 no 1363 0.418387095420222 470 4736863 YCR052W RSC6 SGTC_1041 0206-0046 107 µM 0.204889967929699 0.417979121540723 no 1364 0.418829046691415 447 50494 SGTC_1570 verbenone 133 µM 0.204318371796311 0.418187092649225 no 1365 0.419052357084761 466 29025 A natural terpanoid with antifungal properties. SGTC_1698 5-fluorocytosine 1.055 µM 0.203690495808687 0.418415567138964 no 1366 0.419297684871543 462 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3236 9132701 49.47 µM 0.202814324185612 0.418734438615433 no 1367 0.419640080765944 469 24282524 SGTC_657 3534-0529 86.7 µM 0.20195948024617 0.419045599624183 no 1368 0.419974200740524 453 1049549 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.20144504722191 0.419232876351552 no 1369 0.420175297247101 431 165521 SGTC_47 0149-0135 24.25 µM 0.200672422561686 0.419514180800207 no 1370 0.420477362330984 472 5239155 SGTC_2739 tacrine 100.86 µM 0.199436083585874 0.419964404242403 no 1371 0.420960818378658 461 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3185 9108267 49.47 µM 0.199250716205069 0.420031916409586 no 1372 0.421033314442458 451 4910486 SGTC_716 1683-5115 658 µM 0.19825096073472 0.420396075247783 no 1373 0.421424358877574 476 723597 SGTC_1348 1493-0373 93.8 µM 0.197138982883457 0.420801190891774 no 1374 0.421859389020614 468 3010129 SGTC_1825 st052143 62.6 µM 0.196400809319415 0.42107016855451 no 1375 0.422148231425494 444 674173 SGTC_3339 9145883 14.936 µM 0.19331673987351 0.422194347200176 no 1376 0.423355458539047 471 2030670 SGTC_1579 chlormadinone acetate 49.4 µM 0.191633999079209 0.422807993505164 no 1377 0.424014454323438 478 45114258 A steroidal progestin. SGTC_989 1501-0895 10.3 µM 0.191568871432388 0.42283174742686 no 1378 0.424039963928569 476 2830112 SGTC_1952 st077036 64.1 µM 0.191229556244296 0.422955509949989 no 1379 0.424172874175651 446 2937007 SGTC_29 0299-0004 12.984 µM 0.190331973093781 0.423282932915162 no 1380 0.424524500329137 486 16871 A napthoquinone isolated from Swertia calycina. SGTC_233 rapamycin 362 pM 0.190218618754133 0.423324286410593 no 1381 0.424568910911554 453 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3014 9081533 49.47 µM 0.189861812074806 0.423454460766772 no 1382 0.424708708830054 470 21367265 SGTC_614 0462-0418 107 µM 0.189357202842354 0.423638572427296 no 1383 0.424906432392622 459 5188303 SGTC_41 0478-0632 82.643 µM 0.188937229438434 0.423791816583885 no 1384 0.425071007082718 484 3750424 SGTC_74 000s-0487 160.283 µM 0.188896500962695 0.423806678616775 no 1385 0.4250869680177 381 677548 SGTC_761 k216-0224 480 µM 0.188436565458678 0.423974518994825 no 1386 0.425267218995153 485 1340404 SGTC_692 k241-0027 77.8 µM 0.188218730098339 0.424054016627208 no 1387 0.42535259519427 462 3600480 SGTC_1091 telmisartan 47.6 µM 0.188042482970362 0.424118339160019 no 1388 0.425421674282151 458 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2600 tangeritin 87.95 µM 0.187570426533975 0.424290629172006 no 1389 0.425606705466083 454 68077 A bioactive flavone. SGTC_3048 9093155 49.47 µM 0.186259730101153 0.424769079733367 no 1390 0.426120542765632 475 25236002 SGTC_3325 9138760 55.175 µM 0.185728204153046 0.424963137138439 no 1391 0.426328954704118 431 43844959 SGTC_785 1270-0111 65.3 µM 0.183717702632673 0.425697325058264 no 1392 0.427117460298952 444 6741994 SGTC_3266 9136860 49.47 µM 0.183606869400739 0.425737806267963 no 1393 0.427160936870382 468 4871271 YPR165W RHO1 SGTC_1322 1348-1070 12 µM 0.183115558736348 0.425917264122639 no 1394 0.427353674038022 469 6758089 SGTC_1410 3909-8106 77.9 µM 0.181926999037923 0.426351464992575 no 1395 0.427820007945352 473 1039210 SGTC_336 4111-0029 111 µM 0.180215526542538 0.426976851431457 no 1396 0.428491684787376 472 3131175 SGTC_1672 st016598 6.51 µM 0.177458197079293 0.427984788311846 no 1397 0.429574248974179 473 4665860 YNL267W PIK1 SGTC_2616 abietic acid 100 µM 0.177143050623788 0.428100019595495 no 1398 0.429698013549646 492 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3016 9080866 49.47 µM 0.176939065229352 0.428174608818367 no 1399 0.42977812654599 485 17066299 SGTC_1152 3909-8331 15.9 µM 0.176640550630315 0.428283768179777 no 1400 0.429895370047872 474 16001939 SGTC_491 tetrandrine 80.3 µM 0.175262136330672 0.428787891039572 no 1401 0.43043683103163 467 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_620 0109-0052 432 µM 0.17471364262167 0.428988522177332 no 1402 0.430652323699272 479 493037 SGTC_2826 7992541 19.48 µM 0.172607120294969 0.429759227965024 no 1403 0.431480127361831 500 2985066 SGTC_2797 7859098 81.82 µM 0.171194740990703 0.430276120259432 no 1404 0.432035321267448 454 972681 SGTC_1626 st003712 1.76 µM 0.170932094469692 0.430372254924956 no 1405 0.432138580146019 467 24207035 SGTC_1342 1486-1464 234 µM 0.170842800246402 0.430404939604118 no 1406 0.432173687021841 471 3253938 SGTC_2648 atorvastatin 78.68 µM 0.169397083048987 0.430934186763241 no 1407 0.432742158870174 487 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_70 0141-0289 43.283 µM 0.168460633616766 0.431277067790636 no 1408 0.433110455427367 449 352408 SGTC_3106 9121286 49.47 µM 0.16768015753273 0.431562878750951 no 1409 0.43341745357409 424 15943471 SGTC_1600 coumarin 106 71.1 µM 0.166168616378318 0.432116508088764 no 1410 0.434012128278133 495 100336 A hepatotoxic, DNA x-linker. SGTC_2623 humulene 100 µM 0.165831329703718 0.432240063678741 no 1411 0.434144844967605 446 6187145 An anti-inflammatory. SGTC_183 3914-0051 30.55 µM 0.165433039537543 0.432385974733384 no 1412 0.43430157507274 478 1596232 SGTC_1811 st050069 61.5 µM 0.161688981545434 0.433758034546687 no 1413 0.435775390908428 495 3877702 SGTC_2891 9063876 19.48 µM 0.160812233319908 0.434079446595621 no 1414 0.436120644923436 484 6472478 SGTC_2763 lisinopril 49.32 µM 0.160151576289617 0.434321669369459 no 1415 0.436380836727888 505 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3021 9087658 49.47 µM 0.159523663057356 0.434551909841205 no 1416 0.436628158302208 488 25237042 SGTC_142 0335-0849 62.6745 µM 0.159496228230673 0.434561970029917 no 1417 0.43663896485844 462 3889043 YPR107C YTH1 SGTC_1994 st072947 40.9 µM 0.158064986536213 0.435086856509498 no 1418 0.4372027952078 485 5286565 YDL195W SEC31 SGTC_1495 4469-0029 237 µM 0.156244957009437 0.435754490242345 no 1419 0.437919970645066 463 793680 SGTC_2445 5742597 35.57 µM 0.155635643304207 0.435978043223863 no 1420 0.438160113989495 469 1774255 SGTC_2174 5790901 200 µM 0.15466669066127 0.436333587344869 no 1421 0.438542045471068 483 786020 SGTC_2142 5622915 118.518 µM 0.152958652488996 0.436960454051376 no 1422 0.439215441023695 483 5322196 SGTC_157 1348-1695 65.819 µM 0.151738485950246 0.437408364136628 no 1423 0.439696600611527 463 5380510 SGTC_602 3130-1533 38.1 µM 0.151687533126182 0.437427070122383 no 1424 0.439716695253969 495 720941 SGTC_1415 3966-0071 78.1 µM 0.151524233610718 0.437487022175597 no 1425 0.439781097939085 479 2893185 SGTC_1372 2752-0194 270 µM 0.151306124682081 0.437567098614284 no 1426 0.439867119054764 479 823334 SGTC_1080 nisoldipine 24.4 µM 0.148121010776052 0.438736769936445 no 1427 0.441123634071335 494 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_613 3914-0030 117 µM 0.146694904109491 0.439260654047226 no 1428 0.441686420510894 487 1145395 SGTC_2847 9005661 71.43 µM 0.145423054473617 0.439727961216226 no 1429 0.44218843165268 486 2991449 SGTC_1349 flufenamic acid 69 µM 0.145383280318684 0.43974257652455 no 1430 0.442204132391251 468 3371 A non-steroidal anti-inflammatory. SGTC_2878 9043973 25.97 µM 0.144900211101173 0.439920090442294 no 1431 0.442394829880198 463 6465167 SGTC_736 0958-0254 92.6 µM 0.144429128516851 0.440093211253275 no 1432 0.442580808355217 502 6812352 SGTC_894 0960-0238 55.9 µM 0.143630912519359 0.440386578307431 no 1433 0.442895964543502 498 6741907 YDL195W SEC31 SGTC_3098 9119039 49.47 µM 0.143370120529541 0.440482433872754 no 1434 0.442998939763896 488 17161528 SGTC_312 4092-0653 6.84 µM 0.14283553341475 0.440678935275782 no 1435 0.443210036595652 469 1148278 SGTC_3051 9093778 49.47 µM 0.142715140478681 0.440723190848938 no 1436 0.44325757937523 486 17217378 SGTC_1632 st005650 90 µM 0.14259342028019 0.440767935066818 no 1437 0.443305647116866 463 2759605 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.141300464082122 0.441243270983865 no 1438 0.443816291504504 501 5106787 A p450 inhibitor. SGTC_1887 st057648 70.8 µM 0.141171429633083 0.441290713216807 no 1439 0.443867257929642 489 688672 SGTC_726 3448-4391 34.2 µM 0.141019062541613 0.441346735271837 no 1440 0.443927441549284 487 1356692 SGTC_3322 9139058 2.11 µM 0.139555668534956 0.44188485291912 no 1441 0.444505534566871 451 4908926 YPR165W RHO1 SGTC_3086 9117350 49.47 µM 0.13842359606949 0.442301211013932 no 1442 0.444952824778796 489 2679265 SGTC_524 r073-0010 27.8 µM 0.137848184116133 0.44251286276386 no 1443 0.445180201206547 480 2772106 SGTC_166 k072-0058 166.424 µM 0.137539521330904 0.44262640387346 no 1444 0.445302178027611 508 5846229 SGTC_633 0437-0093 97.7 µM 0.137268354390055 0.442726156085764 no 1445 0.445409341579719 470 2831118 SGTC_2091 4-phenylthiadiazole 200 µM 0.136474762469535 0.443018109818186 no 1446 0.445722987248202 474 270010 SGTC_3171 9103192 49.47 µM 0.134541308231519 0.443729535557568 no 1447 0.446487274377988 495 13018434 SGTC_2362 9071156 126 µM 0.134375998423058 0.443790370713351 no 1448 0.446552629985342 467 653133 SGTC_1038 k292-0204 154 µM 0.133090896339296 0.444263342256914 no 1449 0.447060747382948 491 4454212 SGTC_1165 k072-0275 30.3 µM 0.131000220718559 0.445032968031965 no 1450 0.447887566400815 481 6153523 YGL055W OLE1 SGTC_1763 st044482 94.5 µM 0.130373094014852 0.445263868331048 no 1451 0.448135626375163 508 88505 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.130198834034018 0.445328032001914 no 1452 0.448204558517489 475 6708739 YPR165W RHO1 SGTC_2474 5321570 43.32 µM 0.129822425140116 0.445466633117664 no 1453 0.448353460181559 507 2841384 SGTC_2594 a-mangostin 100 µM 0.128938792703803 0.445792030022019 no 1454 0.448703040359866 493 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3183 9108214 49.47 µM 0.128597187455355 0.445917835667824 no 1455 0.448838195957592 502 4974831 SGTC_1013 4112-3890 241 µM 0.127020639706503 0.44649851363802 no 1456 0.449462031370456 503 705171 SGTC_79 0052-0007 94.094 µM 0.126315979977359 0.446758092833053 no 1457 0.449740903692133 498 2801472 SGTC_921 1561-0023 372 µM 0.125089253844834 0.447210042726997 no 1458 0.450226445331527 501 24050882 SGTC_835 0312-0010 67.2 µM 0.124083599898431 0.447580596471595 no 1459 0.450624541592687 497 1626196 SGTC_2513 baicalein 25.65 µM 0.123797995594147 0.447685841569706 no 1460 0.450737609445306 490 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_213 1246-0773 967 nM 0.123075235685387 0.447952194810818 no 1461 0.451023760615109 488 6251622 SGTC_2874 9043904 71.43 µM 0.122702172416207 0.448089686185726 no 1462 0.451171471764292 470 4463428 SGTC_1719 st032227 49.2 µM 0.11990002303393 0.449122608341437 no 1463 0.452281173114785 497 3125804 SGTC_2232 chlorophetanol 41.5365 µM 0.119630396270931 0.449222015868233 no 1464 0.452387969945858 494 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_326 k292-0812 17.5 µM 0.118694797258887 0.449566982506594 no 1465 0.452758579297513 499 3579357 SGTC_3005 9076496 71.4286 µM 0.11719496612926 0.450120067757332 no 1466 0.453352777939344 484 21368410 SGTC_2756 carbadox 75.1 µM 0.116514235910931 0.4503711292812 no 1467 0.453622502157119 491 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2911 7942208 15.64 µM 0.116057551680268 0.450539571077555 no 1468 0.453803465130683 485 1243384 SGTC_1009 4106-0057 9.87 µM 0.114540468917559 0.45109919030618 no 1469 0.454404683959417 504 2928005 SGTC_617 3770-0098 35 µM 0.114501486612312 0.451113571326633 no 1470 0.454420134002179 497 5962639 SGTC_2128 5255449 168.493 µM 0.113491006001431 0.451486371573572 no 1471 0.454820646592182 481 736008 SGTC_2534 helenine 20.12 µM 0.113192308353615 0.451596579379903 no 1472 0.454939046760962 490 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_801 0866-0028 10.1 µM 0.112944563556864 0.451687990398009 no 1473 0.455037252867648 508 6849771 SGTC_2309 7664088 163.95 µM 0.112932021906491 0.451692617990317 no 1474 0.455042224454489 498 704922 SGTC_1995 st072814 61.1 µM 0.112692417987885 0.451781027810286 no 1475 0.455137206263279 471 5769371 SGTC_201 4262-0159 12.803 µM 0.112519097658409 0.451844981590463 no 1476 0.455205914077374 496 1341029 SGTC_1702 st027038 51 µM 0.110154760692634 0.452717526648973 no 1477 0.456143319799522 477 5521182 SGTC_261 5-fluorouridine 15.376 µM 0.10920460848965 0.45306823945962 no 1478 0.456520102563484 492 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2106 5357045 167.29 µM 0.108910972243512 0.453176631611219 no 1479 0.456636551912456 486 668842 SGTC_3127 9126946 49.47 µM 0.108824730970077 0.453208467162952 no 1480 0.45667075391633 506 27243249 SGTC_3023 9089636 49.47 µM 0.107087814447954 0.45384970529707 no 1481 0.457359657118334 505 17249241 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.106979581366259 0.453889666991103 no 1482 0.457402589245281 479 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1794 st048918 76.9 µM 0.106396920986491 0.454104804197871 no 1483 0.457633717954694 494 672303 SGTC_2351 9026858 72.31 µM 0.106007526288327 0.454248588925562 no 1484 0.457788190361219 489 1409300 SGTC_1462 k081-0014 26.5 µM 0.105965566594019 0.454264082980116 no 1485 0.457804836102268 491 3270634 SGTC_861 0443-0273 110 µM 0.105693129824892 0.454364684789166 no 1486 0.457912915712305 488 6149169 SGTC_84 0443-0269 128.823 µM 0.104912330454396 0.454653024142055 no 1487 0.458222687339045 511 6150058 SGTC_170 4197-0004 226 µM 0.104174809843539 0.454925403143871 no 1488 0.458515312009633 492 218692 SGTC_2792 7535235 81.82 µM 0.103858605919983 0.455042189170728 no 1489 0.458640778543184 483 1281891 SGTC_125 0133-0007 11.75 µM 0.102368409268527 0.455592627101404 no 1490 0.459232128832888 509 26541 SGTC_3278 9139605 49.47 µM 0.102186144265802 0.455659956686392 no 1491 0.459304462728026 487 7958859 SGTC_1215 3852-0577 11.2 µM 0.101290361065338 0.455990881862385 no 1492 0.459659983798555 467 2884876 SGTC_2228 7354201 200 µM 0.101086189679364 0.456066312263936 no 1493 0.459741020463022 512 753451 SGTC_2260 7964312 200 µM 0.100908966410702 0.456131788062025 no 1494 0.459811362638363 476 231951 SGTC_518 1021-0119 62.6 µM 0.100577463252842 0.456254266337913 no 1495 0.459942943844758 481 1097762 SGTC_1545 lovastatin 49.4 µM 0.100503442087408 0.456281615015694 no 1496 0.459972325142684 503 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1740 st038286 13.222 µM 0.0993935404045815 0.456691716320629 no 1497 0.460412905689528 489 716786 SGTC_1615 st002656 86.5 µM 0.0979286708460061 0.457233046451733 no 1498 0.460994466679508 491 1584458 SGTC_1105 epirubicin 18.1 µM 0.0965663516704168 0.457736551201971 no 1499 0.461535389524719 503 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_938 3126-1755 342 µM 0.0959228079743956 0.45797442461687 no 1500 0.461790939980449 500 1777771 SGTC_2461 5755302 26.15 µM 0.0956921590883318 0.458059683161987 no 1501 0.461882534231485 508 2788904 SGTC_1651 st011928 86.1 µM 0.0952623541049072 0.458218564199856 no 1502 0.462053221848502 491 720198 SGTC_487 nimodipine 119 µM 0.0922230008206085 0.459342275846822 no 1503 0.463260431952052 515 4497 L-type voltage-gated calcium channels inhibitor SGTC_2264 7948757 110.76 µM 0.0915611503624303 0.459587019012403 no 1504 0.46352335963073 509 2971411 SGTC_3205 9113483 49.47 µM 0.0895485997625767 0.460331326157206 no 1505 0.464322965832332 515 17018033 SGTC_1488 4013-0813 75.9 µM 0.0884642614723529 0.460732407776395 no 1506 0.464753844076908 511 2910057 SGTC_760 0568-0725 82.9 µM 0.0880884723994041 0.460871416259101 no 1507 0.464903179227418 522 3916171 SGTC_471 1-acyl-paf 4 µM 0.0879368673063384 0.460927497993528 no 1508 0.464963427109457 505 16759367 SGTC_840 0245-0196 390 µM 0.0876047709417406 0.46105034974749 no 1509 0.465095405049206 511 3827528 SGTC_2483 5729050 27.16 µM 0.087486329871915 0.461094165319035 no 1510 0.465142475474482 521 2865180 SGTC_2841 9004761 38.96 µM 0.0870645765985305 0.46125019071265 no 1511 0.465310091104221 500 2991039 SGTC_2629 bisabolol 100 µM 0.0864796844596491 0.461466578333845 no 1512 0.465542552507439 520 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_767 0929-0023 86 µM 0.0859789251037712 0.461651849124616 no 1513 0.46574158525425 515 1204563 SGTC_2448 5185112 27.17 µM 0.0853432072577204 0.4618870637993 no 1514 0.465994271192689 480 5718189 SGTC_3066 9117245 49.47 µM 0.0851875329267875 0.461944665109463 no 1515 0.466056150917405 508 17176980 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.0837909522698377 0.462461451727592 no 1516 0.466611320882493 505 688801 SGTC_1677 st019204 53.9 µM 0.0826916625018599 0.462868274312133 no 1517 0.467048357263755 487 3945625 SGTC_1296 1068-0102 11.9 µM 0.0821541477627493 0.463067210674204 no 1518 0.467262067458791 513 767053 SGTC_1281 0884-0031 11.8 µM 0.0820396389124788 0.463109592054401 no 1519 0.46730759619225 500 1548255 SGTC_896 0964-0007 44.5 µM 0.0812999931157853 0.463383355718524 no 1520 0.467601689733197 483 6756758 SGTC_734 2023-0417 80 µM 0.0810932897317993 0.463459865546962 no 1521 0.467683881065969 520 3935732 SGTC_3312 9133330 71.43 µM 0.0806069005451902 0.463639904468335 no 1522 0.467877289112344 511 17617324 SGTC_1346 1488-2224 62.4 µM 0.0782845259115309 0.464499642843798 no 1523 0.468800863109227 504 3722427 SGTC_2464 5717415 7.67 µM 0.0759373488560863 0.465368731454423 no 1524 0.469734471270194 508 5285744 SGTC_3221 9128209 49.47 µM 0.0743563187100011 0.465954232433535 no 1525 0.470363432580322 516 16460723 SGTC_583 1488-1091 88.9 µM 0.0739545995073223 0.466103012411405 no 1526 0.470523255314203 521 4303273 SGTC_2485 5633444 17.78 µM 0.0738943767161225 0.46612531682135 no 1527 0.470547215174049 514 5724239 SGTC_2176 5809774 33.9695 µM 0.0736917583969281 0.46620036032206 no 1528 0.470627828402836 524 2870539 SGTC_2700 st077718 96.8 µM 0.0726569439810866 0.466583641964834 no 1529 0.471039555836169 499 904970 SGTC_730 1436-0052 41.2 µM 0.0720158325509044 0.466821116773043 no 1530 0.47129465400658 490 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_167 3672-0051 66.205 µM 0.0708757276819935 0.467243453428918 no 1531 0.471748330643412 513 3237971 SGTC_495 decylubiquinone 155 µM 0.0706209150394957 0.467337850435927 no 1532 0.471849732088399 519 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1573 oleylamine 1.06 µM 0.0681162880368071 0.468265802798734 no 1533 0.4728465322464 517 5356789 An amine of the fatty acid oleic acid. SGTC_3024 9090631 49.47 µM 0.0674316088893381 0.468519503385426 no 1534 0.473119053096139 523 25236383 SGTC_314 1671-0008 2.74 µM 0.0651056893190293 0.469381443053367 no 1535 0.474044925312084 509 3913060 SGTC_2496 diffractaic acid 79.83 µM 0.0638089071093085 0.469862067394965 no 1536 0.474561192933455 518 94870 An apoptosis inducer which activates caspases. SGTC_1802 st050112 57.9 µM 0.0636295714592285 0.469928537755791 no 1537 0.474632592413341 520 4662563 SGTC_1150 3909-7983 10.9 µM 0.0622512682886022 0.470439430600778 no 1538 0.475181367717019 529 23965914 SGTC_1406 3909-7906 11.9 µM 0.0619926473146104 0.470535298560738 no 1539 0.47528434366685 515 X1406 SGTC_2935 9038016 29.96 µM 0.0612028981371271 0.470828060469608 no 1540 0.475598810841102 525 6463195 SGTC_654 1124-0271 80.9 µM 0.0611538438414195 0.47084624553606 no 1541 0.475618344085022 520 5403748 SGTC_376 3970-0862 59.1 µM 0.0607856713793516 0.470982733801752 no 1542 0.475764950900814 522 3135186 SGTC_2164 5685496 200 µM 0.0600575121856648 0.471252685754897 no 1543 0.476054914605051 504 759046 SGTC_2880 9042983 58.44 µM 0.0600097643466489 0.471270387872135 no 1544 0.476073928941746 511 6464714 SGTC_484 loperamide 105 µM 0.0587034314175326 0.471754721925723 no 1545 0.476594163088885 515 3955 An opioid-receptor agonist. SGTC_780 0109-0199 192 µM 0.058654700787118 0.471772790034422 no 1546 0.476613570357057 526 610414 SGTC_3006 9075424 71.4286 µM 0.0570804428043058 0.472356516879795 no 1547 0.477240557700272 521 7465181 SGTC_901 1112-0062 60.1 µM 0.0569189457447468 0.47241640254658 no 1548 0.477304881128214 527 1908457 SGTC_3010 9080089 71.4286 µM 0.0558544697288571 0.472811142644978 no 1549 0.477728871031752 507 17027233 SGTC_343 4130-2827 29.8 µM 0.0557456159009351 0.472851510468264 no 1550 0.477772229871489 503 1118244 SGTC_2242 6630449 61.2675 µM 0.0542501942000452 0.473406107154544 no 1551 0.478367915172598 503 691249 YDR170C SEC7 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.053905091662368 0.473534100302056 no 1552 0.478505390003126 523 1377 SGTC_3219 9131112 49.47 µM 0.0523242146068047 0.474120457664721 no 1553 0.479135179637692 521 17612988 YMR079W SEC14 SGTC_3314 9135860 59.4275 µM 0.0519252862122274 0.474268431655058 no 1554 0.479294112983243 532 25252478 SGTC_2998 9066762 71.4286 µM 0.051863229327514 0.474291450654148 no 1555 0.479318836785145 530 4945196 SGTC_2946 9065502 71.43 µM 0.0512839853816528 0.474506315969614 no 1556 0.479549614562784 514 16489101 SGTC_918 glabranin 770.725 nM 0.050555888371676 0.474776407497477 no 1557 0.479839706912493 513 124049 Also referred to as licorice root. SGTC_2515 chrysin 20.77 µM 0.0497797997339699 0.475064314540594 no 1558 0.480148932099797 525 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2565 isoliquiritigenin 100 µM 0.0489074466322992 0.47538794852757 no 1559 0.480496527205712 526 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_516 3992-2719 87.3 µM 0.0487876231339779 0.475432403080595 no 1560 0.480544272868831 495 5350887 YDR037W KRS1 SGTC_112 phenothiazine 287.218 µM 0.0476953037906714 0.475837667910065 no 1561 0.48097953843871 528 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_300 r073-0011 5.04 µM 0.0475866264578641 0.475877990002645 no 1562 0.48102284524787 520 2735780 SGTC_2325 6158266 200 µM 0.0469513063896157 0.476113715058666 no 1563 0.481276018283137 520 3623240 SGTC_569 4130-2812 160 µM 0.0464351330015476 0.476305238858681 no 1564 0.481481717308759 521 743552 SGTC_2582 agaric acid 100 µM 0.0463056680745978 0.476353277094423 no 1565 0.481533310843513 520 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1953 st076800 12.1 µM 0.0460645568588486 0.476442742837919 no 1566 0.481629397767045 517 297591 SGTC_2375 9072683 200 µM 0.0460157135464932 0.476460866582813 no 1567 0.481648862788575 529 16798029 SGTC_439 amiodarone 34.4 µM 0.0452252630131578 0.476754177018535 no 1568 0.48196387893771 515 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_949 1165-0505 146 µM 0.0449829686410392 0.476844087094061 no 1569 0.482060442133665 523 6244267 SGTC_3169 9102970 49.47 µM 0.0435516174379313 0.477375253724745 no 1570 0.482630909382243 531 17027839 SGTC_1692 fluoroquinolonic acid 71 µM 0.0431002264500167 0.477542770841912 no 1571 0.482810819393786 528 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_947 3447-0010 211 µM 0.0414743590980478 0.478146184219664 no 1572 0.483458866868236 525 748350 SGTC_3040 9091894 49.47 µM 0.0406955594671849 0.478435240462493 no 1573 0.48376930084829 525 25236966 SGTC_1743 st037606 46.3785 µM 0.0395859584831513 0.478847095206637 no 1574 0.484211611086006 528 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_912 3474-0017 2.18 µM 0.0395303741559956 0.478867727246839 no 1575 0.484233768680809 529 3360550 SGTC_126 0417-1624 672.48 µM 0.0389747698153859 0.479073962064242 no 1576 0.484455252048021 531 41912 YDL195W SEC31 SGTC_945 3381-0768 11.3 µM 0.0379841777123318 0.479441673886018 no 1577 0.484850148640431 535 1126236 YIL048W NEO1 SGTC_1385 3091-4834 14.1 µM 0.0378271105081053 0.479499979486896 no 1578 0.484912764388495 522 4072814 SGTC_2354 9060492 162 µM 0.0368157036229704 0.479875438693837 no 1579 0.485315976428193 517 6471895 SGTC_1426 4048-4480 71.7 µM 0.0365493203780062 0.479974329715643 no 1580 0.485422176491286 523 14224343 SGTC_106 0092-0003 11.579 µM 0.0360407501295296 0.480163132663778 no 1581 0.485624933071162 529 1072148 SGTC_1956 st077085 54 µM 0.0355342440339576 0.480351173733775 no 1582 0.485826870409283 539 24208685 SGTC_1861 st057647 17.4 µM 0.0350339993339312 0.480536894544218 no 1583 0.486026314978765 537 688668 SGTC_579 4491-1009 110 µM 0.0349388461290095 0.480572221595533 no 1584 0.486064252389564 539 1271041 SGTC_2390 9097792 176.6 µM 0.0346620855463994 0.480674973969921 no 1585 0.486174597049242 525 4497149 SGTC_2160 5660466 132.927 µM 0.0335336479940491 0.481093940049015 no 1586 0.486624516846878 534 2859134 SGTC_990 3985-0011 41.3 µM 0.0326029513735365 0.481439504648142 no 1587 0.486995608113705 537 5399565 YGL099W LSG1 SGTC_24 0417-1663 219 µM 0.0317343705129735 0.481762018456336 no 1588 0.487341942488338 533 4329390 SGTC_2355 9061122 103.12 µM 0.0311423643650755 0.481981843827158 no 1589 0.487578002081495 525 5302957 SGTC_2926 9010726 65.15 µM 0.0301249267438419 0.48235965435779 no 1590 0.487983710541603 524 2994293 SGTC_1568 digitonin 820 nM 0.0293320663686476 0.482654082423866 no 1591 0.488299876317523 542 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3119 9125183 49.47 µM 0.0289073108647448 0.48281181894222 no 1592 0.488469257416482 534 22695334 SGTC_1397 3532-0190 20.1 µM 0.0288866400209075 0.482819495302274 no 1593 0.488477500447731 527 5322280 SGTC_1455 4262-0120 131 µM 0.0287108120759953 0.482884791326954 no 1594 0.488547616566928 528 1529587 SGTC_2357 9067248 200 µM 0.0281471246280466 0.483094127176173 no 1595 0.488772404464025 533 9150235 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0266459597329433 0.483651635340288 no 1596 0.489371057846392 514 803109 SGTC_81 0411-0046 9.971 µM 0.0264886275901514 0.483710067802085 no 1597 0.489433802143122 537 12925265 SGTC_402 epigallocatechin gallate 10 µM 0.0263517187787243 0.483760915413694 no 1598 0.489488401797214 531 65064 An antioxidant. SGTC_2312 7706453 155.7 µM 0.0259945259874065 0.48389357722028 no 1599 0.48963085230321 533 976098 SGTC_1465 k213-0056 144 µM 0.0253595003417405 0.484129430856361 no 1600 0.489884107377714 535 24048857 YMR208W ERG12 SGTC_2828 7998861 71.43 µM 0.0250079640287966 0.484259996665614 no 1601 0.490024305609985 532 2988188 SGTC_3335 9143315 29.6265 µM 0.0248921282684973 0.484303020158284 no 1602 0.490070503011035 535 4899691 SGTC_1055 3448-0672 86 µM 0.0244738705403316 0.484458370147372 no 1603 0.490237312879454 533 748378 SGTC_2536 dehydroabietamide 32.04 µM 0.022858781491202 0.485058271171304 no 1604 0.49088145970081 539 3983547 SGTC_2883 9059145 45.46 µM 0.0226540249180938 0.485134327426437 no 1605 0.490963124606888 540 16476510 SGTC_2067 5224629 34.075 µM 0.022522260594434 0.485183271201274 no 1606 0.491015677558002 526 2835000 SGTC_3332 9141069 11.198 µM 0.0223388789437292 0.485251388571004 no 1607 0.491088817849947 540 17332883 SGTC_1256 0570-0116 285 µM 0.0221922037458458 0.485305871587549 no 1608 0.491147318285097 525 410638 SGTC_1360 1598-0022 39.8 µM 0.021386236098166 0.485605255964016 no 1609 0.491468776529254 538 761525 SGTC_2180 6301957 200 µM 0.0213331160073862 0.485624988215674 no 1610 0.491489963545713 533 845462 SGTC_2064 5220758 200 µM 0.0201425691717716 0.48606724377605 no 1611 0.491964820868098 540 788518 SGTC_839 0122-0028 230 µM 0.019639670298437 0.486254062121276 no 1612 0.492165408803424 535 759448 SGTC_3133 9127736 49.47 µM 0.0188688158462251 0.486540427231131 no 1613 0.492472878230117 529 27243420 SGTC_557 1315-0110 16.2 µM 0.0181476776919034 0.486808329494746 no 1614 0.492760521452595 536 6833801 SGTC_1043 0916-0009 19.3 µM 0.0176756527711258 0.486983689617043 no 1615 0.492948801943923 543 3101130 SGTC_433 pimozide 108 µM 0.0163921343977934 0.48746053710906 no 1616 0.493460777374452 534 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_10 0279-0212 42.575 µM 0.0162848125183072 0.487500409716015 no 1617 0.49350358689548 533 39851 YBR002C RER2 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0160466116540214 0.487588907395424 no 1618 0.493598602875161 540 5024745 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.014674680874723 0.488098626335054 no 1619 0.494145859459639 542 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3253 9135987 49.47 µM 0.0146611861110135 0.488103640196604 no 1620 0.494151242512339 530 4182430 SGTC_379 3970-0972 5.9 µM 0.0144556308525474 0.488180012688895 no 1621 0.494233238505882 539 2898042 YBL034C STU1 SGTC_307 1501-1223 22.3 µM 0.0143217362754159 0.48822976043357 no 1622 0.494286649184571 538 2830329 SGTC_447 ml7 120 µM 0.0139030347943243 0.488385327690864 no 1623 0.494453670274285 543 4216 Selective myosin light chain kinase inhibitor. SGTC_1457 k015-0032 57.3 µM 0.0135524102360931 0.488515602535773 no 1624 0.494593536054895 542 4302660 SGTC_362 0310-0100 9.03 µM 0.0125057339309132 0.488904503217419 no 1625 0.495011064027274 541 790235 SGTC_432 NS 1619 61.3 µM 0.0104979604426996 0.489650536206845 no 1626 0.495811996646235 541 4552 A K+/calcium channel activator. SGTC_627 1391-0720 175 µM 0.0103177098696614 0.489717514134791 no 1627 0.495883902326163 544 997839 SGTC_2906 7926292 26.41 µM 0.0095996558328501 0.489984333186629 no 1628 0.496170350230267 544 2966319 SGTC_1830 st055982 50.3 µM 0.00930455621249777 0.490093989472741 no 1629 0.496288072686413 541 455313 An antimicrobial agent. SGTC_123 0083-0120 66.675 µM 0.00929670783466094 0.490096905867523 no 1630 0.496291203600747 544 16001701 SGTC_1258 0671-0043 57.1 µM 0.00852100992041916 0.490385151629876 no 1631 0.496600650007521 543 4298767 SGTC_2117 5521686 200 µM 0.00756694336156406 0.490739685227067 no 1632 0.496981255167896 545 803312 SGTC_1245 0418-0076 17.2 µM 0.00703536499608738 0.49093722431224 no 1633 0.497193318598443 545 6790114 SGTC_2092 5303694 80.6725 µM 0.00686371396836012 0.491001011785179 no 1634 0.497261795797183 543 1963699 SGTC_2105 5350118 200 µM 0.00685161472145597 0.491005508011554 no 1635 0.497266622584836 540 2133313 SGTC_2221 6807166 181.081 µM 0.00665062772749999 0.491080197374278 no 1636 0.497346802967164 541 674925 SGTC_2302 7771753 200 µM 0.00584191938624692 0.491380726972715 no 1637 0.497669424614458 544 2203047 SGTC_2427 5545055 42.75 µM 0.00581104979737822 0.491392198728295 no 1638 0.4976817395896 543 5372858 SGTC_1911 st060208 74.3 µM 0.00390184499160822 0.492101710817411 no 1639 0.498443393011009 543 688783 SGTC_1983 st071813 46.9 µM 0.00373804789046796 0.492162583441498 no 1640 0.498508738123229 541 11838595 SGTC_925 2064-1272 59.6 µM 0.00271468293814288 0.49254290505466 no 1641 0.498916999528287 540 6815817 SGTC_1331 1472-0049 76.2 µM 0.00237862133947127 0.492667799911998 no 1642 0.499051068273437 544 24051409 SGTC_893 0958-0369 48.9 µM 0.00183833520273677 0.492868594840202 no 1643 0.499266610775157 546 6819948 SGTC_2149 5554786 194.827 µM 0.00176115535970865 0.492897278532638 no 1644 0.499297401027861 543 745063 YPR165W RHO1 SGTC_1881 5652484 16 µM 0.00128263255655204 0.493075121129814 no 1645 0.499488303783275 547 2255129 SGTC_1428 4049-0204 61.7 µM 0.000926637937250284 0.493207427125399 no 1646 0.499630325001111 547 X1428 SGTC_3267 9137951 49.47 µM 0.000158189162590471 0.49349302492579 no 1647 0.499936891655005 547 16643986 SGTC_2407 paclitaxel 400 µM -1.33477941600747e-05 0.493556777947538 no 1648 0.49999467500056 548 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2602 kawain 100 µM -4.8614674508422e-05 0.49356988517376 no 1649 0.499980605550898 549 5369129 SGTC_1539 benzyladenosine 56 µM -0.000869264648082502 0.493874888418569 no 1650 0.499653213622695 549 92208 A nucleotide analog. SGTC_1094 duloxetine 25.4 µM -0.00113923882795632 0.493975227970207 no 1651 0.499545509562364 548 60834 A selective serotonin reuptake inhibitor. SGTC_474 dl-dihydrosphingosine 5 µM -0.00208378914246257 0.494326285814821 no 1652 0.499168689009247 551 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2995 9067767 71.4286 µM -0.00322408227183874 0.494750100563673 no 1653 0.498713779494585 552 11673567 SGTC_385 1494-0393 12.4 µM -0.00477323390486684 0.495325885872261 no 1654 0.498095762412055 552 3090647 SGTC_1958 st076513 41.9 µM -0.00634962338135128 0.495911804871848 no 1655 0.497466883790142 551 732122 YGL099W LSG1 SGTC_2803 7707263 71.43 µM -0.00866190410827628 0.496771258592868 no 1656 0.496544443433398 552 2199229 SGTC_2311 7694451 200 µM -0.0086969382885386 0.496784280604431 no 1657 0.496530467344069 551 2163142 SGTC_2690 usnic acid 100 µM -0.00870409491658879 0.496786940684025 no 1658 0.496527612370616 555 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2420 aureobasidin a 50 nM -0.00917333733684182 0.496961355837277 no 1659 0.496340419209713 557 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2053 5265679 138 µM -0.00922108478175268 0.496979103366277 no 1660 0.496321371540785 552 764595 SGTC_1932 st074806 40.9 µM -0.00999501159333791 0.497266769589795 no 1661 0.496012633672246 549 17251235 SGTC_2096 5468907 200 µM -0.0105517953897489 0.497473725307843 no 1662 0.495790520799202 551 759785 SGTC_3213 9129884 49.47 µM -0.0106748384618064 0.497519460330395 no 1663 0.495741436480047 558 17190742 SGTC_2463 5473429 200 µM -0.0108017307483041 0.497566626137362 no 1664 0.495690816700527 567 5399405 SGTC_2308 7584454 197.62 µM -0.0111647931506522 0.497701576457931 no 1665 0.495545984494567 555 893577 SGTC_399 oxolinic acid 75 µM -0.0112651893158412 0.497738893766693 no 1666 0.495505934738229 553 4628 A DNA gyrase inhibitor. SGTC_2696 st077691 74.316 µM -0.0119088610514528 0.497978147354118 no 1667 0.495249164110109 555 757133 SGTC_1908 st060353 56.5 µM -0.0123617581594617 0.498146490215318 no 1668 0.495068497610079 558 4227716 SGTC_1562 morin hydrate 59.1 µM -0.0133959462376828 0.498530901410767 no 1669 0.494655950493121 554 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2636 apigenin dimethyl ether 100 µM -0.0141351145705817 0.498805653628886 no 1670 0.494361092937083 559 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2076 5212012 200 µM -0.0142989497369059 0.498866551983733 no 1671 0.49429573876745 555 604802 SGTC_1028 k015-0029 4.8 µM -0.0148584754059716 0.499074530677916 no 1672 0.494072544044037 555 4588309 SGTC_1745 st081495 74 µM -0.0148622676359507 0.499075940271075 no 1673 0.494071031330197 558 13842402 YBL026W LSM2 SGTC_1207 2099-0101 141 µM -0.0152729012617418 0.499228575158035 no 1674 0.493907230811309 555 5837381 SGTC_2614 arthonioic acid 13.39 µM -0.0154257135494397 0.499285376396713 no 1675 0.49384627470993 560 6710684 SGTC_1618 st003135 44.5 µM -0.0159264277972898 0.499471494964176 no 1676 0.493646543170591 553 1270615 SGTC_1153 4055-0057 267 µM -0.0168913953452005 0.499830179629559 no 1677 0.493261628654509 556 882706 SGTC_3045 9092950 49.47 µM -0.0170405990763357 0.499885639638918 no 1678 0.493202113544002 561 44120432 SGTC_1090 efavirenz 20.7 µM -0.0176559250347073 0.499885639638918 no 1679 0.492956670944102 556 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2641 levomentholum 100 µM -0.0178202474916612 0.499824559899781 no 1680 0.492891126080797 553 16666 SGTC_2955 9076254 12.21 µM -0.0184303594209363 0.499597777326048 no 1681 0.49264776661852 556 16459619 SGTC_1905 st060207 84.5 µM -0.0185256120914559 0.499562371298535 no 1682 0.492609772787727 546 1948547 SGTC_66 0109-0187 42.4 µM -0.0212068687675012 0.498565733474101 no 1683 0.491540317515781 562 759417 SGTC_1070 indatraline 8.81 µM -0.0216431815893809 0.498403554285797 no 1684 0.49136629383081 554 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1703 st026983 48.3 µM -0.0216709300391483 0.498393240086753 no 1685 0.491355226396756 564 1104023 SGTC_2373 9071805 200 µM -0.0222797596670401 0.498166936196559 no 1686 0.491112397160493 585 10149009 SGTC_773 4358-1457 44.6 µM -0.0224963401439073 0.498086432689654 no 1687 0.491026015702306 563 1186886 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0234019718847233 0.497749807980112 no 1688 0.490664816050669 553 688803 SGTC_3329 9141233 27.5565 µM -0.0243378542930756 0.497401940737072 no 1689 0.490291559353008 560 4909101 YNL103W MET4 SGTC_216 k038-0035 28.382 µM -0.0252384272554619 0.497067199867654 no 1690 0.48993239309601 556 4444231 YPR107C YTH1 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0253209461206136 0.497036527897664 no 1691 0.489899483349153 564 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_206 4546-0025 72.014 µM -0.0263323403159484 0.496660597734849 no 1692 0.489496130003569 568 6620745 YIL048W NEO1 SGTC_793 0488-0545 106 µM -0.0268341835679081 0.496474066188542 no 1693 0.489295994241773 560 292548 SGTC_932 2857-0803 154 µM -0.0274272292640345 0.496253636343169 no 1694 0.489059490301208 579 674898 SGTC_3123 9126162 49.47 µM -0.0275379402956903 0.496212486155569 no 1695 0.489015339666266 554 25239884 SGTC_2131 toluylene red 5.2905 µM -0.0278478096000371 0.496097311037602 no 1696 0.488891767092558 558 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_865 0488-0499 301 µM -0.0289558525067907 0.495685466027033 no 1697 0.488449900206152 560 9634651 SGTC_162 k030-0015 37.8 µM -0.0292155082612343 0.495588956038723 no 1698 0.488346356354758 561 1809920 YMR134W ERG29 SGTC_3165 9101544 49.47 µM -0.0292290015295195 0.495583940808663 no 1699 0.488340975617443 562 5002184 SGTC_679 0422-0091 41.4 µM -0.0301245934889188 0.495251065330099 no 1700 0.487983843430769 559 627384 YHR062C RPP1 SGTC_1277 0873-0036 22 µM -0.0304720020181461 0.495121940684165 no 1701 0.487845311080617 565 5965735 SGTC_1324 1418-0026 34.4 µM -0.031217745055122 0.494844764990978 no 1702 0.487547944151765 599 1372513 SGTC_923 1900-2434 73.3 µM -0.0313603043828048 0.494791779216705 no 1703 0.487491099041115 563 5910570 SGTC_273 hydroxyurea 18.1 mM -0.0317444649627763 0.49464899669575 no 1704 0.487337917413436 557 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1837 st055472 66.5 µM -0.0325488121272763 0.494350043964465 no 1705 0.487017195091104 574 676091 SGTC_844 0330-0132 15.3 µM -0.034144510698145 0.493756978206292 no 1706 0.486380957378345 563 2828079 SGTC_1885 st057546 99.9 µM -0.0342887217641528 0.493703380620186 no 1707 0.48632345915551 564 702008 SGTC_3235 9132602 49.47 µM -0.034612741407297 0.493582955668067 no 1708 0.486194270707338 576 4912240 SGTC_781 4335-2806 94.4 µM -0.0347521478080028 0.493531144145553 no 1709 0.486138689038853 593 845254 SGTC_1404 3909-7820 48.3 µM -0.0358322380489031 0.493129723588649 no 1710 0.485708063659879 565 23741373 SGTC_453 enantio-paf c16 10 µM -0.0361775484022489 0.493001388839496 no 1711 0.485570394023855 572 13871343 A lipid and platelet activating factor SGTC_1441 4106-0040 13 µM -0.0379396749465152 0.49234650527439 no 1712 0.484867889887176 558 2904180 SGTC_1199 1638-0010 4.46 µM -0.0385536071261267 0.492118345885855 no 1713 0.484623145459504 564 3111136 SGTC_1653 st012112 65 µM -0.038903069404239 0.491988474218839 no 1714 0.484483834696258 565 720429 SGTC_1489 4065-0444 182 µM -0.0399308760173819 0.491606512477883 no 1715 0.484074117612136 559 2877968 SGTC_523 1934-0222 13.7 µM -0.0403232348221357 0.491460702961234 no 1716 0.483917715065706 563 1361595 SGTC_1377 2944-0135 198 µM -0.0433962532822867 0.490318739931034 no 1717 0.482692832168561 569 1894137 SGTC_181 1447-1644 8.07 µM -0.045182494603375 0.489654991451501 no 1718 0.481980923641244 576 534600 SGTC_3349 9149703 23.001 µM -0.0457336302905852 0.489450200927108 no 1719 0.481761279373784 572 4910494 SGTC_2529 gangaleoidin 93.61 µM -0.0476786326253742 0.488727501223864 no 1720 0.480986181713555 559 4565183 SGTC_1697 st025554 27.742 µM -0.0477459659247371 0.488702483005621 no 1721 0.480959350171466 574 1269519 SGTC_2271 7849410 118.62 µM -0.0483771389605782 0.488467967862661 no 1722 0.480707839217392 569 972430 SGTC_2899 9053889 58.44 µM -0.0492373679007247 0.488148352417698 no 1723 0.480365066044346 566 6470052 SGTC_1461 k072-0203 53.8 µM -0.0494966493048551 0.488052018684437 no 1724 0.480261753698078 570 5418714 SGTC_771 0250-0039 27.3 µM -0.0507246389500695 0.487595779458264 no 1725 0.47977247143785 596 3005115 SGTC_1280 0880-0253 10.1 µM -0.051440734237283 0.487329733562492 no 1726 0.479487163247443 584 6836607 SGTC_3217 9129673 49.47 µM -0.0522131746946464 0.487042760462889 no 1727 0.479179417682616 587 17248312 SGTC_953 1188-0045 9.7 µM -0.0534784995484859 0.486572688056175 no 1728 0.478675330502936 575 6144426 SGTC_2315 7733312 200 µM -0.0535371334624493 0.486550905808666 no 1729 0.478651972417648 580 726316 SGTC_841 0251-0215 91.2 µM -0.0542550722481489 0.486284197902814 no 1730 0.478365971974823 579 3888614 SGTC_77 0828-0286 12.516 µM -0.0549153252222075 0.486038925177982 no 1731 0.478102961270464 582 745345 SGTC_2443 5493264 126.67 µM -0.055936083014092 0.485659741485951 no 1732 0.477696362863665 592 5340055 SGTC_2025 5147754 141 µM -0.0568837344848039 0.485307726397953 no 1733 0.477318905666102 567 315777 YLR208W SEC13 SGTC_1849 st056239 19.2 µM -0.05702109895032 0.485256701868658 no 1734 0.477264193975827 574 5393181 SGTC_147 4466-0538 29.23 µM -0.0574790880146284 0.485086581917219 no 1735 0.477081781955159 605 6742687 YHR072W ERG7 SGTC_3074 9116018 49.47 µM -0.0587000122384306 0.484633083191817 no 1736 0.476595524795823 571 17027303 SGTC_2786 7743617 45.45 µM -0.0588302859481381 0.484584695634319 no 1737 0.476543642765634 582 583674 SGTC_3292 9120825 59.784 µM -0.0603040565247863 0.484037309082993 no 1738 0.47595673559428 575 24824900 SGTC_666 0272-0154 136 µM -0.0603480928958562 0.484020953591116 no 1739 0.475939199561909 572 6870312 SGTC_3346 9158254 43.5805 µM -0.0616937494650364 0.483521178111528 no 1740 0.475403358846765 563 17639500 SGTC_1421 4029-0249 71.4 µM -0.0631048748880775 0.482997115389706 no 1741 0.474841496219558 580 2894095 SGTC_3178 9107506 49.47 µM -0.0636883509070045 0.482780433027226 no 1742 0.474609190272639 578 8897194 SGTC_1473 k844-0725 134 µM -0.0643140454584742 0.482548077847621 no 1743 0.474360084975055 566 54682906 SGTC_3336 9143619 71.43 µM -0.0643729318083111 0.482526210375421 no 1744 0.474336641300032 582 45595730 SGTC_2757 clomiphene 4.22 µM -0.0662409898427663 0.481832533827472 no 1745 0.473592981621803 577 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3196 9111891 49.47 µM -0.0663618556227321 0.481787653926135 no 1746 0.473544869016836 575 18891510 SGTC_1780 st038448 24.544 µM -0.066374204221497 0.481783068655392 no 1747 0.473539953476393 617 728868 YDL195W SEC31 SGTC_2863 9028737 58.44 µM -0.0664168263798417 0.481767242251869 no 1748 0.473522987133505 607 6460917 SGTC_1177 0983-0204 23.6 µM -0.0674314724670022 0.481390493747254 no 1749 0.473119107397183 575 766818 SGTC_2156 5649887 115 µM -0.0682335220142862 0.481092696264234 no 1750 0.472799871218182 583 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2094 5332512 191.667 µM -0.0684402627609895 0.481015936034423 no 1751 0.472717585951127 582 755774 SGTC_2642 cholecalciferol 100 µM -0.0690527229799113 0.480788541427633 no 1752 0.472473826373311 575 9821465 A vitamin D precursor, similar to steriods. SGTC_50 0929-0078 56.389 µM -0.0698020052033616 0.480510355972211 no 1753 0.472175625575738 588 1377751 SGTC_1201 1889-3372 45.9 µM -0.0702722342606397 0.480335779217612 no 1754 0.47198849085477 582 5392199 SGTC_1304 1165-0502 251 µM -0.0710164404729333 0.480059493708433 no 1755 0.471692335460822 575 767425 SGTC_2353 9059630 146.67 µM -0.0720085532607451 0.479691188152349 no 1756 0.471297550503188 597 4779114 SGTC_1727 st034309 9.9045 µM -0.0727578446769934 0.479413037512392 no 1757 0.470999408539469 636 870305 SGTC_1338 1486-1223 76 µM -0.0740764102690404 0.478923586341864 no 1758 0.470474792779178 601 3444526 SGTC_689 0833-0039 98 µM -0.0749888864307933 0.478584894014209 no 1759 0.470111777169405 598 5374726 SGTC_2804 7954240 19.48 µM -0.077010725088234 0.477834484659981 no 1760 0.469307506460552 590 828705 SGTC_2774 tamoxifen 10.92 µM -0.0773782997441137 0.477698066974462 no 1761 0.469161301656227 576 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2345 9052315 157.45 µM -0.0788411288590116 0.477155194434957 no 1762 0.468579494873563 587 6469265 SGTC_2254 7938975 95.19 µM -0.0799530671490178 0.476742569780219 no 1763 0.468137291700207 623 2969277 SGTC_820 1582-0060 59.9 µM -0.0801389440831919 0.476673595885761 no 1764 0.468063374718518 594 3848840 SGTC_2933 9026794 32.47 µM -0.081516851623613 0.476162313657606 no 1765 0.467515461909832 586 17586027 SGTC_3230 9131665 49.47 µM -0.0827613892301599 0.475700552982352 no 1766 0.46702063534619 585 15943720 SGTC_1939 st074455 53.6 µM -0.0834731061251751 0.475436499354694 no 1767 0.466737680474656 572 1644229 SGTC_1181 1222-0449 220 µM -0.0838251556946581 0.475305889650921 no 1768 0.466597723526633 597 658318 SGTC_959 1222-0044 107 µM -0.0848496917525612 0.474925803920002 no 1769 0.466190443821534 597 6083612 SGTC_98 0074-0023 107.663 µM -0.0848508420116011 0.474925377205908 no 1770 0.466189986583494 625 3563821 SGTC_251 melphalan 456.522 µM -0.0856973348330055 0.474611359757291 no 1771 0.46585351041553 598 460612 A DNA alkylator. SGTC_1957 st077035 62.4 µM -0.0858764416200127 0.474544919795662 no 1772 0.465782319588676 582 705593 SGTC_421 streptovitacin 30 mM -0.0865430302012068 0.474297653883627 no 1773 0.465517375604032 609 91467 include heat shock SGTC_1510 1123-0200 71.5 µM -0.0868725777888341 0.474175414389652 no 1774 0.465386398424244 621 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2691 st077356 60.2 µM -0.0880077115574203 0.473754376500369 no 1775 0.464935273495585 596 2839272 SGTC_2679 rapamycin 1 nM -0.0884098954650227 0.473605207554969 no 1776 0.464775448325762 597 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_225 nsc-122657 1.016 µM -0.0884655572823808 0.473584563025511 no 1777 0.464753329142397 623 275685 SGTC_3296 9122258 64.045 µM -0.0893260493622954 0.473265422353257 no 1778 0.464411396209285 599 4730474 SGTC_264 promethazine 12.5 mM -0.0917108683685744 0.472381027192061 no 1779 0.463463881038552 585 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1655 st012546 55.1 µM -0.0919201186355767 0.472303434477715 no 1780 0.463380753386078 593 720985 YLR208W SEC13 SGTC_884 0851-0618 334 µM -0.0919217120315236 0.472302843629849 no 1781 0.463380120392946 610 9642473 SGTC_1866 st057638 64 µM -0.0931101890152425 0.471862161013059 no 1782 0.462908011469637 594 688802 SGTC_958 1222-0007 33 µM -0.0931145135532209 0.471860557553863 no 1783 0.462906293691249 607 7312461 SGTC_2791 5663188 71.43 µM -0.0931293126055728 0.471855070340712 no 1784 0.462900415266831 592 54690634 SGTC_2511 berberine 10.47 µM -0.0932147700343669 0.471823384421301 no 1785 0.462866470343981 591 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1206 3978-0017 132 µM -0.0937837448310216 0.471612424409306 no 1786 0.46264047225647 623 3873677 SGTC_551 k048-0028 34.9 µM -0.0940063487423336 0.471529891241505 no 1787 0.462552056752852 606 6836383 SGTC_3130 9127414 49.47 µM -0.0942290179869597 0.471447335073738 no 1788 0.462463617150649 588 1494646 SGTC_711 k292-0785 179 µM -0.0944769561296573 0.471355411730434 no 1789 0.462365143450238 597 4146315 SGTC_2369 9071472 200 µM -0.0945705500496828 0.471320712076552 no 1790 0.462327971311543 590 17296037 SGTC_2507 purpurin 79.67 µM -0.0946593026316235 0.471287807534774 no 1791 0.462292722282128 578 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2567 aureobasidin a 60 nM -0.0947905559154536 0.471239146445985 no 1792 0.462240594190989 593 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_277 nystatin 15.5 µM -0.0951014453636069 0.471123888422841 no 1793 0.462117125023604 618 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3047 9092122 49.47 µM -0.0987366718132374 0.469776359822144 no 1794 0.460673675609709 607 17173831 SGTC_715 0868-0130 184 µM -0.100004746494887 0.469306382553638 no 1795 0.460170278590181 600 2876258 SGTC_877 0771-0151 33.1 µM -0.101861571429387 0.468618278407893 no 1796 0.459433276405164 619 6166523 SGTC_904 1141-0088 396 µM -0.10307408948729 0.468168992647128 no 1797 0.45895208453268 622 1378119 SGTC_2553 4-methylesculetin 85.09 µM -0.103311233520896 0.468081126151884 no 1798 0.458857980133547 609 5319502 SGTC_1497 4476-2978 41.3 µM -0.10657539177998 0.466871851623595 no 1799 0.45756292094381 590 1528379 SGTC_1998 st075797 76.8 µM -0.106615609487469 0.466856954030867 no 1800 0.457546967295299 604 24208315 SGTC_369 0957-0393 4.5 µM -0.106900973909861 0.466751249615344 no 1801 0.457433770275842 639 6997992 SGTC_1309 pyrazolanthrone 13.4 µM -0.108055671626483 0.466323551614438 no 1802 0.456975765556437 616 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_593 1203-0218 61.7 µM -0.108130533522776 0.466295824236898 no 1803 0.456946073948629 605 3666956 SGTC_994 3910-0338 138 µM -0.110092505287797 0.465569207115589 no 1804 0.456168005970703 599 3479481 SGTC_2442 5158906 48.48 µM -0.110894072626929 0.465272379179462 no 1805 0.45585017298526 583 1893835 SGTC_155 k072-0202 43.6 µM -0.11266464008251 0.464616790082158 no 1806 0.455148217917376 584 5857737 SGTC_2627 acetyl isogambogic acid 100 µM -0.114723008338026 0.463854757654316 no 1807 0.45433233815944 622 6857789 A caspase activator and apoptosis inducer. SGTC_289 k017-0060 526 µM -0.114741249399709 0.463848005184734 no 1808 0.454325108767536 608 5512909 SGTC_1524 corynanthine 62.1 µM -0.114741655708912 0.46384785477746 no 1809 0.454324947737143 651 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2007 4011539 71.82 µM -0.116606953127936 0.463157415006695 no 1810 0.453585763759532 582 45595301 SGTC_46 0329-0187a 2.197 µM -0.116895212259833 0.463050725746913 no 1811 0.453471546103119 609 46494817 SGTC_1936 st074407 74.3 µM -0.120523850720738 0.461707939131238 no 1812 0.452034093605881 588 809813 SGTC_695 3505-6186 243 µM -0.121933658033016 0.461186353320843 no 1813 0.451475779623912 611 1819379 SGTC_2283 7944793 200 µM -0.122436793162682 0.461000224749018 no 1814 0.451276550483195 585 2970533 SGTC_325 2810-4341 181 µM -0.122806493323255 0.460863464224142 no 1815 0.451130166128677 599 774970 SGTC_1494 4358-1428 177 µM -0.122815689141824 0.460860062539964 no 1816 0.451126525089744 631 1564571 SGTC_1374 2889-5571 141 µM -0.12298040970944 0.46079913018456 no 1817 0.451061305491583 594 2853281 SGTC_725 1497-0963 19 µM -0.124316086924732 0.46030507931632 no 1818 0.450532505290645 585 3549977 SGTC_3301 9125354 19.7965 µM -0.124543164656364 0.460221092079563 no 1819 0.450442612972606 601 41905162 SGTC_1471 k673-0312 37 µM -0.124778100043524 0.460134200469075 no 1820 0.450349612752863 599 24099884 SGTC_1633 st005664 67.9 µM -0.125857872439554 0.459734867713039 no 1821 0.449922215175894 623 2063822 SGTC_2119 5528445 120.635 µM -0.127846988810096 0.458999338448084 no 1822 0.449135031727799 615 791935 SGTC_1720 st037298 9.481 µM -0.127869762663759 0.458990918011083 no 1823 0.449126020235423 641 597396 SGTC_395 anisomycin 6.25 µM -0.128822137264275 0.458638802192254 no 1824 0.448749194238785 632 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_114 0364-0001 490.298 µM -0.129922735455805 0.458231924980684 no 1825 0.448313778226142 612 4003655 SGTC_172 1112-0046 2.638 µM -0.131581149137779 0.457618913233387 no 1826 0.447657798338008 625 2802135 YIL048W NEO1 SGTC_2888 9058547 12.99 µM -0.132154452698202 0.457407022161578 no 1827 0.447431063267603 609 16476514 SGTC_2194 5927483 104.545 µM -0.13262527124922 0.457233018256532 no 1828 0.447244872701579 604 760979 SGTC_2168 5727979 200 µM -0.133434723487945 0.456933882169431 no 1829 0.446924792779759 600 695210 SGTC_248 streptozotocin 5.23457 mM -0.134423484270903 0.456568515066714 no 1830 0.4465338561991 620 5300 DNA alkylating agent. SGTC_2324 6149169 200 µM -0.13609244005521 0.455951885604898 no 1831 0.445874101943503 623 2888231 SGTC_365 0121-0052 13.6 µM -0.13805054104124 0.455228560946608 no 1832 0.44510023696565 608 3101739 SGTC_2115 tiliquinol 12.7705 µM -0.139190445767051 0.454807547073714 no 1833 0.444649829092446 631 71208 A bioactive hydroxyquinoline. SGTC_2452 5863136 48.41 µM -0.139901982693815 0.454544772814196 no 1834 0.444368717367152 601 2184096 SGTC_290 2043-6722 48.1 µM -0.139953741494463 0.454525658796708 no 1835 0.444348269756402 612 773758 YLR208W SEC13 SGTC_1748 st037455 53.6035 µM -0.140347357507871 0.454380303711541 no 1836 0.444192774345232 618 580690 SGTC_2058 5236698 133 µM -0.140458446216317 0.45433928181872 no 1837 0.444148891036521 613 766665 SGTC_2162 5663267 200 µM -0.143138241545207 0.453349858400312 no 1838 0.443090501751287 652 6456493 SGTC_1523 st012844 44.7 µM -0.14408466179355 0.453000493726298 no 1839 0.442716808224917 635 4274103 SGTC_358 0075-0058 9.45 µM -0.144182216237743 0.452964484222362 no 1840 0.442678291796345 693 1069125 SGTC_401 neomycin 50 µM -0.144290805284952 0.452924402057196 no 1841 0.442635419324897 610 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2598 perillyl alcohol 100 µM -0.144324893887436 0.452911819441449 no 1842 0.442621960807364 612 10819 An apoptosis inducer. SGTC_2316 5844804 197.44 µM -0.144598248892377 0.452810921709631 no 1843 0.442514039942505 638 776813 SGTC_2170 morpholine 200 µM -0.144808337306469 0.452733378302144 no 1844 0.44243109969781 629 121171 Reacts with secondary amines. SGTC_3177 9107506 49.47 µM -0.144810379038646 0.452732624709835 no 1845 0.442430293660184 600 8897194 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.146080483991901 0.452263868940362 no 1846 0.441928926327886 600 16725076 SGTC_1808 st050063 61.5 µM -0.147923794649801 0.451583679501423 no 1847 0.441201454685862 618 4011993 SGTC_2917 7979103 53.79 µM -0.149252162086204 0.451093594283831 no 1848 0.440677330749022 648 2980565 SGTC_3078 9116413 49.47 µM -0.151376544830486 0.450309984008765 no 1849 0.439839345375366 611 17177322 SGTC_1929 genistein trimethyl ether 50.5 µM -0.151963668717347 0.450093448632199 no 1850 0.439607795477799 605 136420 SGTC_1877 wortmannin 25 µM -0.152207716381503 0.450003446522277 no 1851 0.43951155404238 624 312145 A covalent inhibitor of PI 3-kinase. SGTC_3093 9117344 49.47 µM -0.152820781213368 0.449777366269746 no 1852 0.439269804595727 609 24824913 SGTC_3069 9117009 49.47 µM -0.152925041695615 0.449738919694554 no 1853 0.439228693880133 604 41904981 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.154578412738638 0.44912929413729 no 1854 0.438576844777249 626 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2951 9072950 58.06 µM -0.154818870703908 0.449040643230607 no 1855 0.43848205695694 604 16488155 SGTC_1602 st001878 87.6 µM -0.154888548581053 0.449014955195219 no 1856 0.43845459080255 639 595405 YLR310C CDC25 SGTC_3343 9148379 18.9835 µM -0.154995671033441 0.448975462942975 no 1857 0.438412365039542 618 1955036 SGTC_2747 doxorubicin 7.63 µM -0.155450028706398 0.448807962993312 no 1858 0.438233273135299 599 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1380 2291-0730 164 µM -0.156072095141092 0.448578651644842 no 1859 0.437988096823411 625 2999191 SGTC_2555 cholic acid 100 µM -0.157366843692182 0.448101425743972 no 1860 0.437477871372396 609 6708657 Influences liver metabolism. SGTC_2378 9074213 121.43 µM -0.15804662707813 0.447850897279095 no 1861 0.437210028653573 599 657714 SGTC_1361 1608-0041 5.61 µM -0.1586800355061 0.447617478634576 no 1862 0.436960484113126 610 X1361 SGTC_1220 1838-0075 193 µM -0.158909111395563 0.447533065868883 no 1863 0.436870241030265 631 5529645 SGTC_2348 9022543 33.42 µM -0.159140574001453 0.447447776029493 no 1864 0.436779061051201 643 3162678 YDL140C RPO21 SGTC_535 2293-4129 48.2 µM -0.159421376604606 0.44734430854424 no 1865 0.436668449094412 652 396118 YIL048W NEO1 SGTC_1694 st024011 44.9 µM -0.160075436185023 0.447103320766894 no 1866 0.436410825361305 644 2787533 SGTC_1259 0671-0132 43 µM -0.160881226401851 0.446806454806303 no 1867 0.436093474422259 624 X1259 SGTC_313 3474-0040 5.03 µM -0.162944725616103 0.446046365085359 no 1868 0.435280977719107 614 1043375 YIL048W NEO1 SGTC_2516 gossypol 71.55 µM -0.163829342047062 0.445720577256438 no 1869 0.434932746071154 641 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1232 0279-0259 161 µM -0.163995685464764 0.445659320146833 no 1870 0.434867270164194 622 1560000 SGTC_3261 9137475 49.47 µM -0.164012829475627 0.445653006820431 no 1871 0.434860522059629 611 17027690 SGTC_1068 loratadine 26.9 µM -0.164474479654793 0.445483008133273 no 1872 0.434678817715123 638 3957 A H1 histamine antagonist. SGTC_2885 9057732 51.95 µM -0.164548031360347 0.445455924278516 no 1873 0.434649869222748 635 6471414 SGTC_1730 st033808 45.1 µM -0.164743407511181 0.445383982393487 no 1874 0.434572974746939 606 1045166 SGTC_3170 9103054 49.47 µM -0.16697576975355 0.444562104749877 no 1875 0.43369455709282 649 16432970 SGTC_2622 2-methoxyxanthone 59.94 µM -0.167297485686314 0.444443679766514 no 1876 0.433567991195972 610 71034 A hepatoprotective. SGTC_1312 1218-2183 165 µM -0.16738809755721 0.444410326051701 no 1877 0.433532344912488 616 6744073 SGTC_2551 apiole 73.87 µM -0.168342072680961 0.444059197162983 no 1878 0.433157088453853 615 10659 A possible DNA adduct former. SGTC_2849 9019321 12.99 µM -0.168411425114391 0.444033672374911 no 1879 0.433129810267801 610 16489627 SGTC_2155 5570423 76 µM -0.168766814015299 0.443902877056905 no 1880 0.432990031212237 640 797402 SGTC_1868 st057644 42.7 µM -0.169334966639188 0.443693790081283 no 1881 0.432766586851318 622 688665 SGTC_279 1273-0055 2.93 µM -0.170155011603275 0.443392031357164 no 1882 0.432444115618425 625 2847562 SGTC_1864 st057645 30.4 µM -0.170580647315848 0.443235419594757 no 1883 0.43227675804085 610 688666 SGTC_2065 5221596 34.26 µM -0.171287244290131 0.442975448319253 no 1884 0.431998954912193 615 788581 SGTC_1828 st055811 49 µM -0.172275457290035 0.442611906025834 no 1885 0.431610489058786 664 5877589 SGTC_301 4119-0100 24.5 µM -0.172540048608392 0.442514576762065 no 1886 0.43150648960074 641 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2784 7567673 72.73 µM -0.172826808674701 0.442409096696888 no 1887 0.431393781923425 629 3471247 SGTC_718 1130-0073 349 µM -0.173607279632463 0.442122033741495 no 1888 0.431087055292016 650 6740020 SGTC_2273 7815444 169.05 µM -0.17632662612318 0.441122076485657 no 1889 0.430018672558043 684 2824616 SGTC_219 mitoxanthrone 164.414 µM -0.176986724140969 0.440879401801351 no 1890 0.429759408779198 625 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_748 act1.228 77.9 µM -0.177830633490902 0.440569184107324 no 1891 0.429427994363999 627 4421505 YNR035C ARC35 SGTC_2200 6600604 21.907 µM -0.178010897494425 0.440502924503105 no 1892 0.42935720873296 656 2904777 SGTC_1316 1272-0050 65.9 µM -0.178115134298757 0.440464610961538 no 1893 0.429316278314139 625 7340392 SGTC_2465 5809242 33.21 µM -0.179204442832695 0.440064255395458 no 1894 0.428888587661393 624 2731748 SGTC_672 1441-0018 53.7 µM -0.179570937101195 0.439929570839442 no 1895 0.428744711293795 622 251141 SGTC_2860 9025725 38.96 µM -0.18160657397633 0.439181612838797 no 1896 0.427945744679827 672 40546248 SGTC_853 0419-0306 21 µM -0.18197031734726 0.439047984692097 no 1897 0.427803010140597 631 762713 SGTC_1191 1487-1166 10.6 µM -0.182341005226728 0.438911812492709 no 1898 0.427657560264646 625 3955771 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.182570540109689 0.438827496472667 no 1899 0.427567500687141 621 279621 SGTC_1370 2001-0092 44.6 µM -0.183325722169558 0.438550111860748 no 1900 0.427271226511825 618 790957 SGTC_193 1273-0060 1.558 µM -0.183698337024016 0.438413258456646 no 1901 0.427125056785862 656 2847393 YHR072W ERG7 SGTC_548 1436-0017 110 µM -0.183706642010183 0.43841020829808 no 1902 0.42712179901153 646 9677137 SGTC_833 3852-0053 558 µM -0.183993571979583 0.438304830249466 no 1903 0.427009248826708 644 3123681 SGTC_2693 st077581 40.7 µM -0.184354983010653 0.438172104473248 no 1904 0.426867491407668 657 25238761 SGTC_1915 st067105 30.6 µM -0.184466714152274 0.438131073367801 no 1905 0.426823668650613 649 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1004 4084-0029 199 µM -0.184896570895048 0.437973222980302 no 1906 0.426655080324732 639 716894 YLR208W SEC13 SGTC_468 gf-109203x 121 µM -0.185097525669399 0.437899432502455 no 1907 0.42657627115236 641 2396 A protein kinase C inhibitor. SGTC_632 0781-2353 4.65 µM -0.185131734185371 0.437886871370033 no 1908 0.426562855764824 632 6811515 YHR007C ERG11 SGTC_881 0833-0569 170 µM -0.185671876853028 0.437688542991736 no 1909 0.426351041910284 616 5418700 SGTC_2212 7123476 200 µM -0.187132090649885 0.437152463447579 no 1910 0.425778533931855 623 1085715 SGTC_2902 5787006 60.46 µM -0.187583951968939 0.43698659763663 no 1911 0.425601403695431 654 591003 SGTC_2738 aclarubicin 5.55 µM -0.187934180377232 0.436858046078152 no 1912 0.425464124020864 632 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2215 7188065 200 µM -0.188892432213181 0.436506353252484 no 1913 0.425088562511971 636 940217 SGTC_381 3461-2219 42.7 µM -0.19001811937845 0.436093273268368 no 1914 0.424647465996755 673 2883159 SGTC_2349 9023730 187.07 µM -0.191838314069847 0.435425485800713 no 1915 0.423934429013169 653 4126287 SGTC_3132 9126706 49.47 µM -0.192053196795975 0.435346662396004 no 1916 0.423850267957049 636 850858 SGTC_2161 5662504 8.5105 µM -0.192179583481025 0.435300302359366 no 1917 0.423800768918366 611 2859334 SGTC_1015 4130-4525 82 µM -0.192973935354075 0.435008945673944 no 1918 0.423489690488803 637 1363237 SGTC_1156 4092-0367 4.88 µM -0.193930903278435 0.434657990664263 no 1919 0.423114992857266 622 1357585 SGTC_3124 9127567 49.47 µM -0.194765338257943 0.43435201495629 no 1920 0.422788329331675 657 17592030 SGTC_1303 1160-0052 261 µM -0.196963192544743 0.433546280992875 no 1921 0.421928170803592 636 3562476 SGTC_2839 9003951 25.97 µM -0.197093308998531 0.433498588890254 no 1922 0.421877259689657 631 2990634 SGTC_929 2805-0021 398 µM -0.197370735136016 0.433396906015995 no 1923 0.421768714567931 678 3098024 SGTC_2643 anethole 100 µM -0.19771673096189 0.433270096998174 no 1924 0.421633349354582 662 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2869 9037858 32.47 µM -0.198254430771912 0.433073041251299 no 1925 0.421423001472676 620 27187042 SGTC_843 0310-0051 143 µM -0.198759076407476 0.432888114304667 no 1926 0.421225604762281 634 2065037 SGTC_1779 st039427 55 µM -0.199094768476498 0.432765108380181 no 1927 0.421094306731864 659 1124498 SGTC_1418 3966-3099 2.4 µM -0.199098629660783 0.432763693584087 no 1928 0.421092796571775 620 740335 SGTC_1986 st071812 45 µM -0.199486917634583 0.432621423425167 no 1929 0.420940937957185 642 11838594 SGTC_2645 abamectin 100 µM -0.203668645392566 0.431089780109595 no 1930 0.419306222973662 626 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_3111 9122088 49.47 µM -0.20582936793485 0.430298775673671 no 1931 0.418462100025121 664 16876704 SGTC_2980 9014342 25.29 µM -0.206399565930939 0.430090082212215 no 1932 0.418239404934512 665 2996599 SGTC_1827 berberine 7.24 µM -0.206663454656141 0.429993505085254 no 1933 0.418136350086601 658 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1789 tunicamycin 25 nM -0.207160735956574 0.429811523099624 no 1934 0.417942165145001 663 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2919 7978188 46.38 µM -0.207979783970725 0.42951182188311 no 1935 0.417622376132914 610 2980291 SGTC_1933 st074711 15.9 µM -0.210041023734584 0.428757765315146 no 1936 0.416817827407312 627 17250958 SGTC_2740 felodipine 17.08 µM -0.210154675388259 0.428716196041452 no 1937 0.416773476684174 639 3333 L-type calcium channel blocker SGTC_1606 st000094 49.2 µM -0.210636946755373 0.428539809078576 no 1938 0.416585289859659 651 1242210 SGTC_501 nsc-95397 161 µM -0.212877008495173 0.42772071176611 no 1939 0.415711447961109 655 262093 SGTC_2402 5553605 200 µM -0.215122384664822 0.426899983689057 no 1940 0.414835951003856 657 6758546 SGTC_2274 7947094 46.08 µM -0.215426397192823 0.426788885514422 no 1941 0.414717445566722 636 2971028 SGTC_3299 9121982 43.1275 µM -0.215473207317007 0.426771779763577 no 1942 0.414699199461107 660 17594604 YPL160W CDC60 SGTC_2220 6782180 200 µM -0.217764613510625 0.425934603752381 no 1943 0.413806258604612 662 833803 SGTC_594 1487-1584 10.8 µM -0.221603100438206 0.424532944082282 no 1944 0.412311434351218 678 5013332 SGTC_1973 st070275 50.2 µM -0.222996403829167 0.424024401227071 no 1945 0.411769152684424 634 17118334 SGTC_2727 riluzole 51.77 µM -0.224951134321054 0.42331115605416 no 1946 0.411008644557402 644 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2932 9016711 44.54 µM -0.225047956958545 0.423275833767429 no 1947 0.410970983375961 674 7117328 SGTC_660 4031-1742 102 µM -0.225337006899454 0.423170387873041 no 1948 0.410858556264265 636 6738706 SGTC_2754 granisetron 64.02 µM -0.226719342400264 0.422666185824195 no 1949 0.410320992833945 675 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2014 4013930 200 µM -0.226726402660163 0.422663610943481 no 1950 0.410318247667524 678 64556 SGTC_1416 3966-0321 25.3 µM -0.22693854981818 0.422586242298766 no 1951 0.410235762775108 661 582530 YLR208W SEC13 SGTC_2909 7941780 10.49 µM -0.227761228109231 0.422286245318528 no 1952 0.409915934989667 665 1243215 SGTC_1420 4'-methoxyflavone 42 µM -0.228810294136996 0.42190375944469 no 1953 0.409508182731783 648 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1345 1488-0192 31.4 µM -0.22914835103614 0.421780520733684 no 1954 0.40937680719446 672 658348 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.229356515883632 0.421704638006279 no 1955 0.409295915316111 633 2724278 An inhibitor of dopamine biosynthesis. SGTC_3149 9097855 49.47 µM -0.229729452038534 0.421568698152602 no 1956 0.409151003743972 631 25236625 YMR079W SEC14 SGTC_975 1335-0046 28.5 µM -0.230316900710467 0.421354584789593 no 1957 0.408922764362338 687 16486740 SGTC_2417 cerulenin 830 nM -0.230471127336798 0.421298376101464 no 1958 0.408862848344128 672 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3153 9100258 49.47 µM -0.2340346981732 0.420000063319695 no 1959 0.407479020658896 681 25236848 SGTC_1294 1000-1494 117 µM -0.234405049868488 0.419865183069224 no 1960 0.407335269309221 636 712797 YDL207W GLE1 SGTC_223 busulfan 5 mM -0.237111369622829 0.418879841515862 no 1961 0.406285196084502 656 2478 A DNA alkylator. SGTC_1393 3470-5649 58.2 µM -0.237211042991593 0.418843561201909 no 1962 0.406246534855044 663 4108395 SGTC_2229 7354935 190 µM -0.238176806180341 0.418492066865527 no 1963 0.405871982764383 671 318112 SGTC_1075 aripiprazole 15.2 µM -0.238327377093884 0.418437271685941 no 1964 0.405813594577156 651 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3115 9123671 49.47 µM -0.238333032636119 0.418435213573903 no 1965 0.40581140151938 639 3286988 SGTC_532 1548-0774 215 µM -0.240095285860643 0.417794019889048 no 1966 0.405128194341804 691 5932993 SGTC_2681 menadione 3.18 µM -0.240472820046256 0.417656682894308 no 1967 0.404981865801358 651 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.243500973164011 0.416555485234791 no 1968 0.403808665658816 644 3256 An antibiotic and ribosome inhibitor. SGTC_1587 estradiol valerate 56.1 µM -0.243831488589258 0.416435331698481 no 1969 0.403680665925924 681 13791 A steroid. SGTC_2136 5328288 199.296 µM -0.244484193160408 0.416198074454668 no 1970 0.403427921315599 648 262395 SGTC_944 3370-0224 231 µM -0.245363438421646 0.415878518255244 no 1971 0.403087517883044 664 4580514 SGTC_348 k064-0012 10.7 µM -0.245537004280603 0.415815443393694 no 1972 0.403020329814662 654 5066323 SGTC_1924 st058459 75.1 µM -0.248913081613248 0.414588990159419 no 1973 0.401714008026011 662 688683 SGTC_2718 lomofungin 53.02 µM -0.248964018486631 0.414570492277577 no 1974 0.40169430714502 669 5351222 A RNA synthesis inhibitor. SGTC_1046 2001-0062 216 µM -0.249387506173506 0.414416708763824 no 1975 0.401530524269891 654 739778 SGTC_502 l-744,832 89.3 µM -0.251237174557106 0.413745182145229 no 1976 0.400815372454623 672 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2780 5215298 71.43 µM -0.251732869552515 0.413565261631518 no 1977 0.400623774362475 692 2834131 SGTC_2198 6589944 200 µM -0.252565026302282 0.413263257703964 no 1978 0.400302179449909 662 5290268 SGTC_2966 9084041 48.03 µM -0.252686675740878 0.413219113335365 no 1979 0.400255172521198 658 17741380 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.253594177249067 0.412889832201359 no 1980 0.399904547749562 678 1273210 SGTC_2853 9015042 58.44 µM -0.253633374677028 0.412875611043608 no 1981 0.399889405139558 644 6457456 SGTC_427 1354-0053 47.3 µM -0.255132522076365 0.41233179369464 no 1982 0.39931037307106 690 6813657 SGTC_1581 himbacine 57.9 µM -0.255974323110734 0.412026503159 no 1983 0.398985332064503 693 5281825 An alkaloid muscarinic receptor antagonist. SGTC_791 1348-1292 225 µM -0.256678635487793 0.41177111563951 no 1984 0.398713432760835 687 5437054 SGTC_2018 5133068 143 µM -0.256747154179044 0.411746272380234 no 1985 0.398686983789029 684 785362 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.256773586248869 0.411736688830501 no 1986 0.398676780842418 671 4174840 SGTC_2606 farnesol 9.78 µM -0.258205097766372 0.411217740469689 no 1987 0.39812431192336 645 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1006 4099-6547 255 µM -0.258282052729348 0.411189847319329 no 1988 0.398094618162585 661 3146833 SGTC_1401 3807-4679 7.6 µM -0.259427219269528 0.410774822569295 no 1989 0.39765281523835 646 3291456 SGTC_1229 0139-0193 12.2 µM -0.260201498694909 0.410494269181674 no 1990 0.397354174138913 649 3090752 SGTC_542 3381-0244 89.3 µM -0.260417357149106 0.410416062912901 no 1991 0.397270927824706 688 1112843 SGTC_3187 9109394 49.47 µM -0.260528964710862 0.410375628501904 no 1992 0.397227887944271 650 17098090 SGTC_2241 6772625 37.8075 µM -0.261272544785475 0.410106260498407 no 1993 0.396941168754749 630 2285411 SGTC_1270 0831-1170 17.3 µM -0.261590488004072 0.40999109588689 no 1994 0.39681858910105 657 6764716 SGTC_3241 9133421 49.47 µM -0.262054035984252 0.409823204589541 no 1995 0.396639891337536 665 17018221 SGTC_2829 7992743 58.44 µM -0.262481786240409 0.409668293446994 no 1996 0.396475012853414 674 16462845 SGTC_962 1254-0300 21.5 µM -0.263753732423362 0.409207737406279 no 1997 0.395984844279459 656 7340576 SGTC_2827 7993847 71.43 µM -0.264636281629034 0.408888250803867 no 1998 0.395644833786042 673 2985692 SGTC_321 4534-3890 65.3 µM -0.265136883679086 0.408707057601119 no 1999 0.395452007351686 668 699746 SGTC_1295 1013-0063 9.78 µM -0.265762355990739 0.408480694956839 no 2000 0.39521111822695 667 6826038 SGTC_2663 amphotericin b 100 µM -0.266056345928832 0.408374308560541 no 2001 0.395097907251815 669 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1062 mesoridazine 14.2 µM -0.267101339802452 0.407996210424564 no 2002 0.394695568022571 658 4078 A neuroleptic. SGTC_2667 digitoxin 100 µM -0.267236308122196 0.407947382625805 no 2003 0.39464361125613 649 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3315 9136395 68.55 µM -0.267391049235818 0.407891403337185 no 2004 0.394584045154343 726 16876844 SGTC_575 k072-0246 11.9 µM -0.269335372796524 0.407188183646956 no 2005 0.393835806992134 658 6796779 SGTC_1204 4049-0315 18.3 µM -0.269359220456512 0.407179560317144 no 2006 0.393826632072978 667 588402 SGTC_2456 5770359 74.46 µM -0.269545298041951 0.407112276083126 no 2007 0.39375504439827 691 3118787 SGTC_2717 st081029 62.2815 µM -0.271167256345277 0.406525904631262 no 2008 0.393131197717504 711 5292846 SGTC_2621 lithochol-11-enic acid 100 µM -0.27210852303671 0.406185713264851 no 2009 0.392769288147766 696 6708711 SGTC_2207 7258803 200 µM -0.272348489816039 0.406098996105599 no 2010 0.39267703764075 682 3666799 SGTC_435 c-PAF 6.7 µM -0.274352733622671 0.405374899777424 no 2011 0.391906781470417 680 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.274639442944612 0.405271343397455 no 2012 0.39179663001355 663 5357218 A potent inhibitor of glutathione S-transferases. SGTC_149 3970-0822 46.1 µM -0.275435613064002 0.40498380995426 no 2013 0.391490793251484 663 3114250 YBL034C STU1 SGTC_1991 st073000 8.92 µM -0.276196855925597 0.404708938300192 no 2014 0.391198435979473 687 4301969 YIL048W NEO1 SGTC_845 0330-0138 4.51 µM -0.277076861612026 0.404391242039305 no 2015 0.390860544144131 695 9039800 SGTC_688 0527-0193 473 µM -0.278012344576033 0.404053586706864 no 2016 0.390501441284417 664 4007154 SGTC_3172 9105863 49.47 µM -0.278372517214351 0.403923604224323 no 2017 0.390363207075192 674 2348785 SGTC_14 0354-0009 295 µM -0.279026457614239 0.403687631199215 no 2018 0.390112260275348 665 1713507 SGTC_2924 9010168 62.78 µM -0.28092523270569 0.403002661125058 no 2019 0.389383873377615 667 2993929 SGTC_676 falcarinol 140 µM -0.281402143781127 0.402830665401541 no 2020 0.389200987013815 703 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3022 9087993 49.47 µM -0.282445462565316 0.402454463019071 no 2021 0.388800979648771 654 17173644 SGTC_506 n9-isopropylolomoucine 153 µM -0.282866897345567 0.40230252664888 no 2022 0.388639435376804 692 6610355 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.283318812129881 0.402139617975712 no 2023 0.388466228914173 693 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1173 0443-0020 122 µM -0.285287881220831 0.401429996090114 no 2024 0.387711798316672 684 5331295 SGTC_2072 5231554 129 µM -0.28578990892987 0.401249125004461 no 2025 0.387519518720597 691 789545 SGTC_2428 5615643 7.78 µM -0.286134299623539 0.401125059787229 no 2026 0.387387630988005 684 2253075 SGTC_102 gallobenzophenone 83.616 µM -0.287738405270435 0.400547319409765 no 2027 0.386773494753316 665 70837 SGTC_1205 4161-2785 76 µM -0.289229357777417 0.400010527668602 no 2028 0.386202933593148 716 3498106 SGTC_2098 5376439 882.5 nM -0.289382757343804 0.399955309498935 no 2029 0.386144244228399 667 2844116 SGTC_952 1185-0122 232 µM -0.290599569847416 0.399517372959446 no 2030 0.38567879454958 674 678600 SGTC_2267 7931562 200 µM -0.290624377093575 0.399508446027797 no 2031 0.385669307102152 661 934880 SGTC_2020 4017018 200 µM -0.291572410192692 0.399167334040127 no 2032 0.385306786353088 694 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2767 sibutramine 71.45 µM -0.295559047865255 0.397733746464441 no 2033 0.383783426035436 706 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1079 idarubicin 2.36 µM -0.295563645830649 0.397732093837532 no 2034 0.383781670108104 703 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2292 7671323 168.05 µM -0.296003274805121 0.397574088368586 no 2035 0.383613790238273 681 937504 SGTC_328 k915-0120 63.5 µM -0.297309788356935 0.397104618295097 no 2036 0.383115004654992 676 6624543 SGTC_1211 1056-0033 32.3 µM -0.297408008381964 0.397069330867171 no 2037 0.38307751517258 680 6741922 SGTC_1216 1165-0504 9.65 µM -0.298937251335539 0.396520029870025 no 2038 0.382493961746018 687 6304004 SGTC_2795 7780010 54.55 µM -0.30323291355977 0.394978138316589 no 2039 0.380856183848288 669 953673 SGTC_1701 st028638 40.4 µM -0.303686365791233 0.394815470950496 no 2040 0.380683423128667 685 3490878 SGTC_482 fipronil 114 µM -0.304195604137779 0.394632813234212 no 2041 0.380489436823024 659 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1133 3473-0247 50 µM -0.305583860674425 0.39413497993346 no 2042 0.379960755165997 695 711311 SGTC_1111 tnp00062 510.699 nM -0.309406525500569 0.392765055796904 no 2043 0.378506153569205 668 676306 SGTC_55 0767-0285 6.563 µM -0.309499121401028 0.392731888704633 no 2044 0.378470940200239 692 3116166 SGTC_1813 st051246 8.6015 µM -0.30955897520248 0.392710449978195 no 2045 0.378448178887226 670 5291959 SGTC_783 0848-0141 92.7 µM -0.309741213238252 0.39264517707458 no 2046 0.378378879670982 668 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2041 5107442 45.335 µM -0.310124445178291 0.392507923258147 no 2047 0.378233161754287 680 793005 SGTC_2306 7482397 179.52 µM -0.31030792774888 0.392442214043482 no 2048 0.378163401522365 723 891448 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.310437392027295 0.392395851833026 no 2049 0.378114181481614 708 364106 SGTC_2329 6138490 200 µM -0.310903051370498 0.392229108066596 no 2050 0.377937162351064 719 720019 SGTC_3227 9130768 49.47 µM -0.311241572578348 0.392107902470386 no 2051 0.377808490520531 689 17720899 SGTC_1096 rimcazole 32.2 µM -0.312100729859811 0.391800333107172 no 2052 0.37748198593624 694 18528119 A dopamine reuptake inhibitor. SGTC_2566 crystal violet carbinol 226 nM -0.312229344346071 0.391754296273526 no 2053 0.377433116244069 730 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_198 3454-2873 16.191 µM -0.31419113385239 0.391052272971377 no 2054 0.376687938073928 694 710957 SGTC_1547 harmine 94.2 µM -0.314558107311003 0.390920991422495 no 2055 0.376548595524444 660 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1010 4112-3296 15.2 µM -0.316038986279383 0.390391346338547 no 2056 0.375986458359572 693 704384 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.318077461469391 0.389662606473305 no 2057 0.37521308981721 721 6708760 SGTC_2034 5197015 53.07 µM -0.31951513419064 0.389148882072331 no 2058 0.374667958470351 735 780676 SGTC_1483 3453-0561 55.9 µM -0.321472129323363 0.38844989936179 no 2059 0.373926314932969 704 4546991 SGTC_977 1348-1378 135 µM -0.322029328209818 0.388250949791829 no 2060 0.373715238157325 675 X977 SGTC_463 ikarugamyin 104 µM -0.323526290749131 0.38771660005871 no 2061 0.373148350025284 704 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1847 st056231 15 µM -0.323983667618736 0.38755337900123 no 2062 0.372975199634677 676 5393180 SGTC_585 0kpi-0023 191 µM -0.324018234236872 0.38754104424821 no 2063 0.37296211469951 702 64601 SGTC_505 gw-5074 63.9 µM -0.325169840880439 0.387130169857581 no 2064 0.37252626646339 685 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3166 9102297 49.47 µM -0.325545345214526 0.386996223371818 no 2065 0.372384184699607 694 25237072 SGTC_3028 9087778 49.47 µM -0.325572389840811 0.386986576778372 no 2066 0.372373952336965 655 17217395 SGTC_2776 terbinafine 19.92 µM -0.328405029099126 0.385976585531393 no 2067 0.371302720498366 649 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2585 alliin 100 µM -0.32921043275135 0.385689555681833 no 2068 0.370998318934409 733 87310 A garlic compound which reacts with lipids. SGTC_1829 berberine 14.4 µM -0.330433634878738 0.385253750505585 no 2069 0.370536165235188 714 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2558 carylophyllene oxide 100 µM -0.332571920632973 0.3844922655707 no 2070 0.369728721004158 712 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1799 st045822 46.1415 µM -0.333746114342039 0.384074301758404 no 2071 0.369285574273239 727 3674992 SGTC_3264 9137442 49.47 µM -0.334966432431949 0.383640062428034 no 2072 0.368825203963829 703 17015726 SGTC_1755 st041960 45.185 µM -0.336159557150488 0.383215640854418 no 2073 0.368375274370614 731 2257073 SGTC_2095 5432005 200 µM -0.336613019495853 0.383054370717664 no 2074 0.368204320146291 721 783734 SGTC_3255 9139072 49.47 µM -0.337643633875031 0.382687916646833 no 2075 0.367815878070636 687 17646060 SGTC_509 pifithrin 175 µM -0.338627869307757 0.38233805148446 no 2076 0.367445042533895 705 4817 A p53 inhibitor. SGTC_422 cantharidin 155 µM -0.340373950484707 0.381717610258969 no 2077 0.366787466663973 673 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2518 prenyletin 46.28 µM -0.340580882340945 0.381644100528816 no 2078 0.366709561785804 691 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3228 9131799 49.47 µM -0.340949675043067 0.381513102516118 no 2079 0.366570733796815 693 17015818 SGTC_2022 5136654 200 µM -0.34113236153229 0.381448215891399 no 2080 0.366501969925036 731 1713771 SGTC_330 1488-0319 80.1 µM -0.341148916758209 0.381442335967484 no 2081 0.36649573868836 679 6846614 SGTC_2775 cyproheptadine 69.59 µM -0.343872648987768 0.380475320807253 no 2082 0.365471030929375 698 2913 A selective serotonin reuptake inhibitor. SGTC_320 4092-0846 5.34 µM -0.344041251069001 0.38041548595464 no 2083 0.365407631829504 677 1359356 SGTC_2433 5607874 27.82 µM -0.344876990751539 0.380118934250084 no 2084 0.365093424649196 689 2252428 SGTC_3190 9110366 49.47 µM -0.346819257857973 0.379430017655164 no 2085 0.36436355420317 725 17123768 SGTC_1992 st073643 23.3 µM -0.349412334813184 0.378510857411088 no 2086 0.363389887179957 712 3161292 SGTC_204 PMA1.184 62.41 µM -0.351324286754315 0.377833573151009 no 2087 0.362672538293329 700 2252213 YGL008C PMA1 SGTC_3184 9108758 49.47 µM -0.351785744732113 0.377670163780858 no 2088 0.362499475068603 707 902885 SGTC_2071 5230951 39.92 µM -0.352257442091235 0.377503151113955 no 2089 0.362322600744123 684 1799272 SGTC_1030 k029-0042 36.7 µM -0.353658202761659 0.37700732250268 no 2090 0.361797525020803 707 6080581 SGTC_1531 st059297 52.4 µM -0.354129210224834 0.376840645042724 no 2091 0.361621026054408 688 7566702 SGTC_766 1391-0721 126 µM -0.355427102711829 0.376381473026869 no 2092 0.361134823799652 727 1020919 YIL115C NUP159 SGTC_3038 9091290 49.47 µM -0.356386130153736 0.376042297944947 no 2093 0.360775707473918 733 25236843 SGTC_1144 3486-0183 12.5 µM -0.356403231414866 0.376036250683955 no 2094 0.360769304867926 742 6744069 SGTC_3337 9144342 33.5465 µM -0.356621256871256 0.375959156299139 no 2095 0.360687680911433 671 17682949 SGTC_3321 9137793 26.8275 µM -0.357380175007472 0.375690839440744 no 2096 0.360403608094082 681 4904192 SGTC_1464 k208-0027 110 µM -0.357715496706182 0.375572304994641 no 2097 0.36027811740052 716 X1464 SGTC_304 1310-0298 97 µM -0.357979936697011 0.375478835139255 no 2098 0.36017916407121 710 1550234 SGTC_2665 lovastatin 100 µM -0.358367550905047 0.375341840917312 no 2099 0.360034135932778 705 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2921 7974240 10.71 µM -0.358825779727367 0.375179909698107 no 2100 0.359862712905317 728 2979074 YDR527W RBA50 SGTC_499 genistein 192 µM -0.359061220653531 0.375096716944893 no 2101 0.359774645606252 710 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.359316524293671 0.375006512293134 no 2102 0.359679157020082 707 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1078 idebenone 36.1 µM -0.359589446627765 0.374910090111931 no 2103 0.359577088382553 687 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1440 4100-1550 40 µM -0.360100296442207 0.374729630284579 no 2104 0.359386065555676 711 742806 SGTC_2051 5263410 176 µM -0.360395586574518 0.374625330321155 no 2105 0.359275663302114 697 227584 SGTC_3012 9080433 71.4286 µM -0.360471513750146 0.374598513427735 no 2106 0.359247277759291 717 17688859 SGTC_2409 alverine citrate 63.97 µM -0.361674354352204 0.374173760385201 no 2107 0.358797696871036 670 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2982 9019404 25.97 µM -0.36175454298213 0.374145449201972 no 2108 0.358767732036 680 22333232 SGTC_941 3237-0776 460 µM -0.361822320055082 0.374121520539154 no 2109 0.358742405821317 715 760008 SGTC_1974 st069448 26.9 µM -0.362261168264115 0.373966597131552 no 2110 0.358578436731137 711 6323587 YNR016C ACC1 SGTC_2284 7945075 39.21 µM -0.362463585442156 0.373895146118455 no 2111 0.35850281535285 702 1245402 SGTC_1002 4049-0206 172 µM -0.362509416484752 0.37387896887155 no 2112 0.358485694025797 691 4662749 SGTC_2685 mycophenolic acid 18.85 µM -0.363932440202225 0.373376786667326 no 2113 0.357954229773518 676 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2143 5623677 140.463 µM -0.364923232305835 0.373027265022976 no 2114 0.357584355800083 668 5375313 SGTC_1972 st070201 17.4 µM -0.365107665172425 0.372962214182791 no 2115 0.357515519662872 698 2829099 SGTC_2561 acetosyringone 100 µM -0.365930339555682 0.372672094959141 no 2116 0.357208528227894 721 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1988 st071872 53.4 µM -0.36684089512148 0.372351068311481 no 2117 0.356868850553429 706 16414116 SGTC_521 r062-0005 13.8 µM -0.367606183353271 0.372081325878259 no 2118 0.356583451776877 702 2832033 SGTC_727 3032-0951 202 µM -0.369242025621738 0.371504948411698 no 2119 0.355973666853941 716 3652836 SGTC_814 3342-0569 96 µM -0.370032765766878 0.371226439874108 no 2120 0.355679038442066 699 4346283 SGTC_1020 4335-0961 93.3 µM -0.372125444238989 0.370489698094168 no 2121 0.354899726388093 739 669075 SGTC_556 4058-0063 51.5 µM -0.372170727126236 0.370473761181794 no 2122 0.354882869766305 728 6615692 SGTC_2835 9006588 71.43 µM -0.372383637387826 0.370398832275063 no 2123 0.354803617414761 691 2345538 SGTC_1266 0828-0227 32.9 µM -0.372633381214098 0.370310946902497 no 2124 0.354710662381082 702 3913820 SGTC_235 0330-0087 5 mM -0.37263414313209 0.370310678792324 no 2125 0.354710378807274 705 46494818 YHR062C RPP1 SGTC_1017 4239-0030 168 µM -0.374015807255906 0.369824590859909 no 2126 0.354196277897726 686 1149593 SGTC_933 2914-0560 114 µM -0.375835917467146 0.369184569178756 no 2127 0.353519441909551 709 463887 SGTC_477 mead ethanolamide 10 µM -0.376746738135105 0.368864425098099 no 2128 0.353180912868692 692 16061185 SGTC_1491 4138-0063 26.5 µM -0.378995951573782 0.368074239849835 no 2129 0.352345435082081 720 23883227 SGTC_176 1486-1328 72.834 µM -0.38021119807429 0.367647535903987 no 2130 0.351894323737234 689 22310231 SGTC_3350 9150499 3.57 µM -0.381285738818965 0.36727037335848 no 2131 0.351495617314849 710 4910996 YPR165W RHO1 SGTC_2842 9000675 19.48 µM -0.381658028481009 0.367139729966454 no 2132 0.351357517975639 677 2989072 SGTC_2028 5153890 36.43 µM -0.381928581869136 0.367044797382013 no 2133 0.351257169604093 724 2830968 YPR165W RHO1 SGTC_2048 5246248 200 µM -0.382474143707981 0.36685339373486 no 2134 0.351054852017028 692 677046 SGTC_1804 st050076 49.1 µM -0.382984823123833 0.366674258144822 no 2135 0.350865508568136 711 3895976 SGTC_1967 st070177 51.4 µM -0.384386939819946 0.366182574524552 no 2136 0.3503458394651 748 5729214 SGTC_140 0062-0056 502.533 µM -0.38597925939808 0.365624458369758 no 2137 0.349756014718565 714 3758964 SGTC_972 1319-0219 195 µM -0.388025054563944 0.364907814168826 no 2138 0.348998746271026 724 23903702 SGTC_2358 9037157 4 µM -0.388056893638187 0.364896664628768 no 2139 0.34898696550913 713 2388925 SGTC_1365 1672-3266 55.4 µM -0.38885531578335 0.364617107201391 no 2140 0.348691589298789 730 6415873 SGTC_1776 st049249 45.9 µM -0.392334151715656 0.363399878564624 no 2141 0.347405666422718 701 1822314 SGTC_1781 st038725 66.3 µM -0.393327600406603 0.363052527852672 no 2142 0.347038767718615 693 4270275 YIL048W NEO1 SGTC_802 4112-3352 742 µM -0.395834845136715 0.362176392830152 no 2143 0.346113434612808 693 704594 SGTC_2961 9083290 32.55 µM -0.397628487897299 0.361550062291205 no 2144 0.345452029031647 727 17741490 SGTC_1269 0831-0796 3.05 µM -0.399330359220542 0.360956120619535 no 2145 0.344824900105843 741 927758 SGTC_3090 9117696 49.47 µM -0.399567273360814 0.360873465715737 no 2146 0.344737632477513 738 7923821 SGTC_199 4063-0024 41.6 µM -0.399663653441377 0.360839842370833 no 2147 0.344702133114456 723 306215 SGTC_1643 st009866 20.2 µM -0.399845990079128 0.36077623499422 no 2148 0.344634977391659 718 3156273 YOR207C RET1 SGTC_3064 1327-0027 10 µM -0.399882265114748 0.360763581058368 no 2149 0.344621617653257 698 16000455 YPR107C YTH1 SGTC_998 3996-0085 177 µM -0.401601622375745 0.360163987267475 no 2150 0.343988617841245 710 715391 SGTC_876 0720-0963 56.8 µM -0.401681272020336 0.360136219260532 no 2151 0.343959304547788 762 765861 SGTC_3160 9100216 49.47 µM -0.402916606981352 0.359705642847444 no 2152 0.343504786950432 722 17191039 SGTC_2173 5763948 167 µM -0.402943852382436 0.359696148458201 no 2153 0.343494765079269 716 2867177 SGTC_713 1488-1073 324 µM -0.404942641529865 0.358999853425288 no 2154 0.342759836661247 735 3312542 SGTC_1500 4488-1866 171 µM -0.405700178707384 0.358736081188863 no 2155 0.342481455477385 749 2900003 SGTC_991 3996-0057 64.7 µM -0.405701501061071 0.358735620808023 no 2156 0.342480969611123 705 715343 SGTC_811 0416-0114 265 µM -0.40630815449148 0.358524434510395 no 2157 0.342258097265353 747 6612453 SGTC_1912 st060209 90.8 µM -0.406332069016039 0.358516110346601 no 2158 0.34224931267187 760 688787 SGTC_366 0181-0206 4.31 µM -0.406356394498295 0.358507643205684 no 2159 0.342240377207647 744 274874 SGTC_1906 st060206 94.7 µM -0.407347228998604 0.358162815664426 no 2160 0.341876489708362 753 5133468 SGTC_1183 1254-0324 198 µM -0.410771897061139 0.356971864278811 no 2161 0.34061990090862 709 5799357 SGTC_560 2332-1943 155 µM -0.410901176045972 0.356926933844284 no 2162 0.340572500024607 740 21177716 SGTC_3182 9108849 49.47 µM -0.413696238191233 0.355956006510543 no 2163 0.339548291210895 711 17133045 SGTC_2287 7945887 168.79 µM -0.414056511100839 0.35583092544284 no 2164 0.339416360553465 707 1245853 SGTC_59 0330-0160 1.33 µM -0.415508448725892 0.355326993034869 no 2165 0.338884865772782 740 4293482 SGTC_522 1273-0010 11.6 µM -0.415984749986397 0.355161735433095 no 2166 0.338710581207538 735 5705015 SGTC_1469 k284-2957 126 µM -0.417706261404122 0.354564666743239 no 2167 0.338080946896525 724 23884841 SGTC_3225 9130819 49.47 µM -0.417955544067603 0.354478238058619 no 2168 0.337989810469644 765 4547121 SGTC_1314 1222-0010 41.1 µM -0.418120813171605 0.35442094180903 no 2169 0.337929394190844 733 3526027 SGTC_3004 9076122 71.4286 µM -0.418729152638998 0.354210068288109 no 2170 0.33770704373177 747 44782551 SGTC_2956 9076196 2.52 µM -0.419875218917541 0.353812919732675 no 2171 0.337288305914147 752 16423868 SGTC_1914 st062367 72.6 µM -0.420272101402328 0.353675424330217 no 2172 0.337143344043008 725 978205 SGTC_751 0833-0568 350 µM -0.421484457645338 0.353255535630263 no 2173 0.336700679073848 749 6954252 SGTC_910 3454-3003 490 µM -0.42259610857127 0.352870682227797 no 2174 0.336294983145441 756 820824 SGTC_905 2-aminofluorene 215 µM -0.424112582544915 0.352345921867079 no 2175 0.335741854778948 708 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2276 7947513 42.08 µM -0.425013441757587 0.352034321675526 no 2176 0.335413437972809 746 2105100 SGTC_2121 5257820 149.641 µM -0.425528407224059 0.351856243734191 no 2177 0.335225758866868 732 791256 SGTC_1534 6-azauridine 81.6 µM -0.425528587966365 0.351856181238192 no 2178 0.335225693002571 718 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_983 1491-0821 12.2 µM -0.427756383020572 0.35108617206593 no 2179 0.334414247682969 712 46495113 SGTC_3295 9122362 53.5725 µM -0.430286705425694 0.350212339310586 no 2180 0.333493548361907 756 4730473 SGTC_588 3970-1144 52.9 µM -0.430322639940164 0.350199935221909 no 2181 0.33348048020304 715 1888707 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.431151149495783 0.349913989723101 no 2182 0.333179235567382 740 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2967 9089538 49.85 µM -0.431550273496017 0.349776269456249 no 2183 0.333034153162667 756 728216 SGTC_27 0485-0001 32.618 µM -0.432034061131877 0.349609361963472 no 2184 0.33285832885184 729 2054479 SGTC_78 0336-0123 156.75 µM -0.432056589184933 0.349601590457896 no 2185 0.332850142312837 708 6765896 SGTC_3094 9117742 49.47 µM -0.433117846706439 0.349235559777625 no 2186 0.332464579004652 767 17149698 SGTC_1486 3970-0793 4.53 µM -0.433130996135378 0.349231025381476 no 2187 0.332459802822972 749 2844330 SGTC_1088 bifonazole 369 nM -0.433901633797022 0.348965319401834 no 2188 0.332179936644982 739 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3294 9122953 26.2835 µM -0.435288053112503 0.348487486294892 no 2189 0.331676677753105 741 16459826 SGTC_1484 3473-2379 286 µM -0.437833657377441 0.347610763167759 no 2190 0.330753435289242 734 671917 SGTC_488 nitrendipine 139 µM -0.438734201671435 0.347300804466212 no 2191 0.330427070941078 738 4507 Dihydropyridine L-type calcium channel blocker. SGTC_141 0443-0274 32.331 µM -0.438956994761792 0.347224136969218 no 2192 0.330346348854088 732 1627241 SGTC_1681 tripelennamine 100 µM -0.440960084590155 0.346535115354811 no 2193 0.329620947019999 697 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2508 celastrol 40.54 µM -0.441019519391858 0.346514678748574 no 2194 0.329599432987298 702 122724 Celastrol is a natural product and antioxidant. SGTC_1616 st002734 56.1 µM -0.441994164662914 0.34617961156609 no 2195 0.329246714282363 718 4026101 SGTC_3247 9135149 49.47 µM -0.442015353997678 0.346172328353667 no 2196 0.32923904766619 746 8934436 YOR116C RPO31 SGTC_3209 9113616 49.47 µM -0.442025250819558 0.346168926630873 no 2197 0.329235466873577 762 16649353 SGTC_1553 gossypol 38.6 µM -0.442954172406181 0.345849694195412 no 2198 0.328899441325011 723 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1501 4491-0275 38.4 µM -0.443489539520832 0.34566576011724 no 2199 0.328705841870432 738 5104718 SGTC_2907 7721985 69.9 µM -0.444101644191325 0.345455506237408 no 2200 0.328484548898447 735 3267881 SGTC_2904 7225135 42.03 µM -0.444387134794428 0.345357458415163 no 2201 0.328381356618865 766 4446116 SGTC_2497 7-hydroxyflavone 100 µM -0.44457632691597 0.345292488698706 no 2202 0.328312979210985 731 5281894 SGTC_539 4859-0462 2.54 µM -0.444939995570046 0.345167615492723 no 2203 0.328181559025423 716 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2820 7989630 71.43 µM -0.445384758669379 0.34501491973455 no 2204 0.328020862368622 722 2984098 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.446359555418868 0.34468034148206 no 2205 0.327668771450607 762 61125 An anti-inflammatory. SGTC_280 3448-3607 3.04 µM -0.446561695248139 0.344610976480047 no 2206 0.32759577888445 737 626179 SGTC_2552 juarezic acid 87.02 µM -0.44848866352939 0.343949993031296 no 2207 0.326900282955398 729 1549512 SGTC_931 2812-0076 566 µM -0.449117640305961 0.343734346192302 no 2208 0.32667339787084 748 3450959 SGTC_2231 micatex 6.853 µM -0.449176358145378 0.343714217173612 no 2209 0.326652220386832 735 20737 An antifungal of unknown mechanism. SGTC_449 xestospongin c 11.1929 µM -0.45048481692186 0.34326578043624 no 2210 0.326180449787904 751 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2846 9008642 19.48 µM -0.450685723849827 0.343196944866286 no 2211 0.326108036510046 797 2992898 SGTC_1982 st072467 71.9 µM -0.45072742176761 0.343182658803558 no 2212 0.32609300806933 752 3163533 SGTC_1439 4092-1168 46 µM -0.453689336834609 0.342168455847238 no 2213 0.325026221409844 749 2886240 SGTC_686 1319-0111 510 µM -0.453955098669727 0.342077510618859 no 2214 0.32493057246037 790 4562600 SGTC_2429 5902844 64.44 µM -0.454227195673454 0.341984406950092 no 2215 0.324832655408238 756 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_708 3448-5400 146 µM -0.455016598184211 0.341714350792191 no 2216 0.32454864887126 760 3462195 SGTC_1290 0986-0249 10.2 µM -0.455851901599227 0.341428680033955 no 2217 0.324248239445762 754 53329 SGTC_864 0469-0573 172 µM -0.45712905245658 0.340992074683943 no 2218 0.323789144694544 759 689425 SGTC_2294 7971431 200 µM -0.458121509458199 0.340652941384571 no 2219 0.323432573232687 783 5741572 SGTC_25 0118-0223 35.662 µM -0.459969551360714 0.340021788770373 no 2220 0.32276903804789 756 5333628 SGTC_58 0957-0393 9 µM -0.461800959156792 0.339396759112327 no 2221 0.322112031499837 744 6997992 SGTC_2986 9022445 71.43 µM -0.462042259846247 0.339314440001952 no 2222 0.322025507700918 777 6459286 SGTC_1946 st076057 65.1 µM -0.462620790465967 0.339117107004547 no 2223 0.321818101807522 756 953009 SGTC_1499 4480-0877 67.3 µM -0.464181651202764 0.338584927903308 no 2224 0.321258803070443 736 2861909 SGTC_1066 ketoconazole 628 nM -0.464470870052502 0.33848635340884 no 2225 0.321155212563586 771 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2877 9040724 71.43 µM -0.46530650900599 0.338201604681002 no 2226 0.320855987101467 753 6463895 SGTC_2259 7964009 200 µM -0.467610312058977 0.337417050250414 no 2227 0.320031644594718 737 313134 SGTC_3269 9137823 49.47 µM -0.468017857985206 0.337278334920656 no 2228 0.319885909568913 729 17682936 SGTC_1771 st048882 4.1505 µM -0.468321428534934 0.337175023786248 no 2229 0.319777373332471 742 4580403 SGTC_739 1486-1183 203 µM -0.470224977695554 0.336527488045114 no 2230 0.319097145301644 742 4346692 SGTC_816 0325-0417 81.3 µM -0.470550732333716 0.336416723658532 no 2231 0.318980798715204 741 68101 SGTC_2192 5915882 198.485 µM -0.470635369040238 0.336387947472076 no 2232 0.318950572771682 748 2876149 SGTC_2984 9022109 38.96 µM -0.471397108825562 0.336129001734792 no 2233 0.318678590113494 772 6459207 SGTC_3034 9090421 49.47 µM -0.471418596570857 0.336121698319937 no 2234 0.318670919231731 752 17173761 SGTC_2938 9059746 27.26 µM -0.471879626506895 0.335965014938836 no 2235 0.318506355487879 757 6471769 SGTC_3099 9120367 49.47 µM -0.472413251486573 0.335783695348353 no 2236 0.3183159237813 758 24824940 SGTC_335 4077-0256 27.6 µM -0.4733627217438 0.335461170871416 no 2237 0.317977210450158 760 3121989 SGTC_1335 1486-0900 202 µM -0.474338372858484 0.335129879315159 no 2238 0.317629315932554 722 X1335 SGTC_703 3875-0075 71.8 µM -0.475353701347482 0.334785251067383 no 2239 0.317267444305459 777 2850814 SGTC_2873 9040596 71.43 µM -0.476914693348525 0.334255682186139 no 2240 0.316711434295511 800 6463863 SGTC_2644 guaiazulene 100 µM -0.477082875852767 0.334198645677256 no 2241 0.316651554013439 743 3515 A coloring agent. SGTC_541 4513-1321 94 µM -0.479178479837998 0.333488275232415 no 2242 0.315905831218687 744 747515 SGTC_591 4299-0174 154 µM -0.47959101432809 0.333348503989366 no 2243 0.31575911849588 751 5509088 SGTC_2049 5262831 67.185 µM -0.480093553024819 0.333178269586821 no 2244 0.3155804361196 759 763417 SGTC_1778 st046819 58.9 µM -0.480115298104027 0.333170904241788 no 2245 0.315572705424154 765 671715 SGTC_3287 9117173 37.0625 µM -0.48106991132922 0.332847627603893 no 2246 0.315233405967509 739 2789709 SGTC_1452 4194-0072 190 µM -0.481882469709445 0.33257255522507 no 2247 0.314944719980037 761 1343545 SGTC_1903 st060211 78.3 µM -0.482166398154309 0.332476459220922 no 2248 0.314843872433277 748 688960 SGTC_2732 terfenadine 20 µM -0.483189730233491 0.332130202341943 no 2249 0.314480513296437 763 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_380 3970-0968 6 µM -0.484022619286229 0.331848489924084 no 2250 0.314184908202392 754 2891601 SGTC_1273 0849-0096 14.1 µM -0.484708128849483 0.331616697738463 no 2251 0.313941699728282 770 5286025 SGTC_1949 st076024 69.1 µM -0.485713650379968 0.331276816156295 no 2252 0.31358510202936 768 2921930 SGTC_1925 st057770 10.1 µM -0.486073964406494 0.331155058329817 no 2253 0.313457362787414 746 5989122 SGTC_3155 9099265 49.47 µM -0.486284915417281 0.331083781749197 no 2254 0.313382586399045 778 25236499 SGTC_2816 7982706 58.44 µM -0.486689146822991 0.330947216277431 no 2255 0.313239318808201 767 2981853 SGTC_2963 9082507 9 µM -0.488366945334683 0.330380629682794 no 2256 0.31264497533921 782 16459611 SGTC_3193 9111931 49.47 µM -0.488682757838571 0.330274024343389 no 2257 0.312533156294362 769 17087244 SGTC_2416 tofa 880 nM -0.489581524599806 0.32997071298112 no 2258 0.312215026367695 758 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2279 7948423 32.93 µM -0.490997162721896 0.329493197094678 no 2259 0.31171422714823 725 1247112 SGTC_2040 5100729 123 µM -0.493423312451889 0.328675467117012 no 2260 0.310856756774859 759 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2005 4024620 188 µM -0.49427036765973 0.328390161323055 no 2261 0.310557624769203 766 236743 SGTC_2957 9076800 11.52 µM -0.49438227251478 0.32835247692083 no 2262 0.310518115661787 768 16459615 SGTC_680 0417-1641 114 µM -0.494564724286068 0.328291039310646 no 2263 0.310453703960306 740 2835990 SGTC_1746 st038117 42 µM -0.497629553470769 0.327259704160117 no 2264 0.309372584736313 751 2898218 SGTC_1753 st043925 64 µM -0.499065708789548 0.326776881233282 no 2265 0.308866547059844 762 670181 SGTC_1337 1486-1011 40.3 µM -0.499729777059619 0.326553725226496 no 2266 0.308632681279914 745 X1337 SGTC_2062 5245942 200 µM -0.501595345454977 0.325927144810515 no 2267 0.307976097098389 752 1376160 SGTC_394 menadione 8.33 µM -0.502314622825377 0.325685695340905 no 2268 0.307723112375414 778 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.502343540538128 0.325675989672976 no 2269 0.307712943328207 750 2333 A French combination drug. SGTC_1101 ebselen 5.29 µM -0.504241770055965 0.325039144583979 no 2270 0.307045745561177 772 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2251 lansoprazole 556 µM -0.504642809930842 0.324904663312683 no 2271 0.306904867977727 775 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2372 9071633 200 µM -0.504664214700886 0.324897486261884 no 2272 0.306897349695538 751 21321366 SGTC_1389 3405-0187 19 µM -0.505074281161226 0.324760002927525 no 2273 0.306753332280825 757 799890 SGTC_1184 1269-1718 139 µM -0.505848598553832 0.324500461970362 no 2274 0.30648146944145 749 5403821 SGTC_3112 9123419 49.47 µM -0.507826365276692 0.323837927736516 no 2275 0.305787559074089 787 17015854 SGTC_1474 0330-0125 5.35 µM -0.50809782710146 0.323747033930918 no 2276 0.305692369517144 765 X1474 SGTC_1383 3049-0032 20.7 µM -0.508988627564209 0.323448840280376 no 2277 0.305380097770952 779 712864 SGTC_743 1275-0778 158 µM -0.511748325984946 0.322525757070776 no 2278 0.304413579767477 761 2849257 YMR203W TOM40 SGTC_2490 carminic acid 95.39 µM -0.512476155865975 0.322282489345555 no 2279 0.304158901941748 754 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_65 0798-0905 34.986 µM -0.512890408336271 0.322144064788453 no 2280 0.3040139916306 830 3602145 SGTC_2543 pimpinellin 60.67 µM -0.513389243793298 0.321977409135055 no 2281 0.303839534068567 749 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_2396 5342950 42.78 µM -0.513842385917569 0.321826050167784 no 2282 0.303681095541815 769 1886677 SGTC_2482 5981709 142.65 µM -0.514085174646149 0.32174496580388 no 2283 0.303596221039958 771 877755 SGTC_2730 imipramine 71.33 µM -0.514273997054867 0.321681910487079 no 2284 0.303530219499676 748 3696 A tricyclic antidepressant. SGTC_995 3931-2021 34.6 µM -0.5180709576377 0.320415046350498 no 2285 0.302204381233632 771 730143 SGTC_3233 9132340 49.47 µM -0.518889166512939 0.320142322371426 no 2286 0.301919016447912 813 17682950 SGTC_1560 lithocholic acid 53.1 µM -0.518892277542227 0.320141285593778 no 2287 0.30191793165261 756 9903 A bile acid which acts as a detergent. SGTC_860 0443-0016 25.1 µM -0.519098158508238 0.320072677087884 no 2288 0.301846146216612 771 5337942 SGTC_1514 1189-1591 158 µM -0.522045741473945 0.319091089589025 no 2289 0.300819241522679 798 767698 YMR146C TIF34 SGTC_2735 sertaconazole 140 nM -0.522493501897367 0.31894208962817 no 2290 0.300663384821629 779 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_349 k015-0014 24 µM -0.523207116565772 0.318704682580181 no 2291 0.300415064789843 748 2196908 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.524471015236451 0.318284388321756 no 2292 0.29997548724475 810 6728940 SGTC_796 1234-0020 70.7 µM -0.525498761308917 0.317942796093002 no 2293 0.299618257087318 735 46495034 SGTC_1614 st002383 48.6 µM -0.525644346611178 0.317894420382707 no 2294 0.299567669262978 756 1947235 SGTC_1902 st060212 70.5 µM -0.525650901087292 0.317892242506297 no 2295 0.299565391811723 748 688944 SGTC_1072 oxiconazole 14.9 nM -0.526212279667848 0.317705734858189 no 2296 0.299370361508429 752 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_616 4092-0450 108 µM -0.527020284594297 0.317437371364767 no 2297 0.299089751103376 778 787165 SGTC_1233 0325-0408 14.2 µM -0.527810163020783 0.317175120964309 no 2298 0.298815551291246 786 12874 SGTC_510 ag-490 170 µM -0.52849003482962 0.316949467751862 no 2299 0.298579630892803 767 5328779 SGTC_224 benfluorex 43.875 µM -0.52952544548416 0.316605940018399 no 2300 0.29822049881171 780 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2191 5911152 200 µM -0.532249875115467 0.315702786915274 no 2301 0.297276471812743 754 2875902 SGTC_2897 9048598 12.99 µM -0.534067470316142 0.315100861990957 no 2302 0.29664742739467 768 6467404 SGTC_1018 4259-0013 28.1 µM -0.534665117276003 0.314903049010011 no 2303 0.296440723357161 776 6801262 SGTC_1186 1319-0216 26 µM -0.535356601109352 0.314674243551331 no 2304 0.2962016470173 772 4565136 SGTC_2003 4023581 200 µM -0.535800421815253 0.31452742495603 no 2305 0.296048245319708 751 16641307 SGTC_2133 5320837 200 µM -0.535933419311508 0.314483434283032 no 2306 0.296002283314067 773 2841355 SGTC_1711 st032263 62.8 µM -0.538082750652087 0.313772880226899 no 2307 0.295259960241246 780 3958979 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.538279694000159 0.313707806598927 no 2308 0.29519198401257 797 7104 SGTC_3297 9117502 71.43 µM -0.53859233936399 0.313604514845268 no 2309 0.295084087309416 763 7453720 SGTC_599 1935-0052 86.5 µM -0.538938583298445 0.313490139850209 no 2310 0.294964616640647 768 9557311 SGTC_44 0929-0055 61.211 µM -0.539413990356408 0.313333127525388 no 2311 0.294800614853146 736 1379590 SGTC_1941 st076221 61.8 µM -0.53988725730061 0.313176855612783 no 2312 0.294637393111317 736 2828568 SGTC_2556 citropten 84.59 µM -0.5403317096487 0.31303012877316 no 2313 0.294484147003069 746 2775 A potential DNA crosslinker. SGTC_2523 spermine 47.74 µM -0.542565066299665 0.312293280349844 no 2314 0.293714648430041 758 1103 A DNA binding polyamine. SGTC_570 0987-0065 62.6 µM -0.542595701456191 0.31228317814153 no 2315 0.293704099620795 761 3104428 SGTC_2132 5317594 122.667 µM -0.543403207676675 0.312016946870234 no 2316 0.293426108825621 792 794577 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.543789143212082 0.311889740272241 no 2317 0.293293290342133 781 4620898 SGTC_1922 5578187 25 µM -0.545760409619088 0.311240349605581 no 2318 0.292615320344409 754 1350412 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.545939824447451 0.311181274425891 no 2319 0.292553651065744 778 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2656 pseudo-anisatin 100 µM -0.549220758341724 0.310101833802412 no 2320 0.291426980174177 797 6708809 A neurotoxin. SGTC_2330 7979373 200 µM -0.549346885263396 0.310060370097496 no 2321 0.291383708691355 765 1863007 SGTC_1375 2910-0797 186 µM -0.549672553752667 0.309953319096189 no 2322 0.291271992577288 796 742508 SGTC_1492 4158-0558 28.5 µM -0.550749408530147 0.309599459212702 no 2323 0.290902734720295 758 3967268 SGTC_1297 1068-0111 14.1 µM -0.551605023694298 0.309318425528725 no 2324 0.290609496890882 779 767057 SGTC_1302 1159-0335 255 µM -0.55401735331564 0.3085266772473 no 2325 0.289783484808665 779 649284 SGTC_619 1652-1634 108 µM -0.558761200415258 0.306972300798521 no 2326 0.288162352701752 791 5400454 SGTC_1882 5615643 20 µM -0.560540341055813 0.306390236187236 no 2327 0.287555465694563 779 2253075 SGTC_3076 9116187 49.47 µM -0.560696784507524 0.306339077394047 no 2328 0.287502129802937 776 27241210 SGTC_419 nsc-638432 893 µM -0.560852733063832 0.306288084194438 no 2329 0.287448967290918 775 368090 SGTC_1529 apigenin 74 µM -0.561491848846928 0.306079140646347 no 2330 0.287231142742008 814 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_651 3253-0966 34.4 µM -0.562415489840129 0.305777289872371 no 2331 0.286916483922275 779 781462 SGTC_2603 homopterocarpin 100 µM -0.562571454195148 0.305726332905876 no 2332 0.286863367322082 785 101795 A weak amylase inhibitor. SGTC_1141 3253-0389 52.6 µM -0.562590229462124 0.305720198869098 no 2333 0.286856973365358 805 5402031 SGTC_404 fumagillin 50 µM -0.562813313736983 0.30564731954264 no 2334 0.286781006714633 790 12015870 A methionine aminopeptidase binder. SGTC_1707 st032323 6.317 µM -0.562838298753493 0.305639157675368 no 2335 0.286772499187402 783 3132057 YMR211W DML1 SGTC_2537 larixol 68.93 µM -0.5640963216276 0.305228323654737 no 2336 0.286344290640094 773 6708759 SGTC_1319 1306-0155 43.7 µM -0.564160655628853 0.305207320611527 no 2337 0.286322400654068 788 3122360 SGTC_1122 capsaicin 818.572 nM -0.564551470189994 0.305079745641829 no 2338 0.286189440996069 793 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2280 7785178 200 µM -0.565695481041422 0.304706438334618 no 2339 0.28580040385564 765 2954328 SGTC_1878 temozolomide 1 mM -0.566641302269279 0.304397956635353 no 2340 0.285478953958079 784 5394 DNA alkylating agent. SGTC_1630 st005209 31.3 µM -0.566865564990258 0.304324833243989 no 2341 0.285402760548978 789 3367314 SGTC_1940 st075990 51.1 µM -0.566914435243424 0.304308899584348 no 2342 0.285386158133055 799 1084979 SGTC_2227 7312221 64.1025 µM -0.566933943946703 0.304302539069562 no 2343 0.285379530679598 802 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1246 0422-0085 105 µM -0.567332060299668 0.304172752245873 no 2344 0.285244299487477 798 264295 SGTC_2337 9009472 200 µM -0.56991733219249 0.303330548597874 no 2345 0.284366884370254 793 5742383 SGTC_2712 st079126 47.7 µM -0.570749909676493 0.303059541985685 no 2346 0.284084590811176 778 3152970 SGTC_226 1,3-diallylurea 8.28947 mM -0.570944637619705 0.302996173056245 no 2347 0.284018585739528 786 74537 YKL182W FAS1 SGTC_2446 5162541 200 µM -0.571174572175873 0.302921354724483 no 2348 0.283940656466509 779 1549321 SGTC_1362 1611-0397 101 µM -0.571322323969647 0.302873282180194 no 2349 0.28389058592365 790 27816 SGTC_1540 guanosine 70.6 µM -0.57291637734629 0.302354858104877 no 2350 0.283350657563353 791 6802 Guanosine is a purine nucleoside SGTC_274 sirtinol 40.1 µM -0.573352663945618 0.302213036735091 no 2351 0.283202967008782 767 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_582 0987-0078 156 µM -0.574575805993438 0.301815595711411 no 2352 0.282789109294495 802 1625765 SGTC_1059 3448-6867 171 µM -0.574606649079981 0.30180557676637 no 2353 0.282778677100996 793 3934407 SGTC_382 3229-0966 23.2 µM -0.574687878230491 0.301779191328856 no 2354 0.282751203491013 805 5722370 SGTC_3204 9114183 49.47 µM -0.574768092571879 0.30175313654657 no 2355 0.282724074371895 761 17027248 SGTC_880 0833-0487 87.2 µM -0.576590424079433 0.301161489503647 no 2356 0.282108084773059 791 76075 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.576959108601625 0.301041854181474 no 2357 0.281983539632817 765 6708561 SGTC_2189 6047310 154.431 µM -0.577645084527079 0.300819317240559 no 2358 0.281751880941254 784 711535 SGTC_3084 9116877 49.47 µM -0.577936365108146 0.300724845574394 no 2359 0.281653541281475 798 27241325 SGTC_697 0508-1955 564 µM -0.578104173620403 0.300670425952738 no 2360 0.281596894720934 798 6243113 SGTC_2238 6671620 73.2395 µM -0.578389129708374 0.300578026030246 no 2361 0.281500715632262 761 729941 SGTC_824 1304-0008 100 µM -0.579524699922947 0.300209933205865 no 2362 0.281117592637828 777 768245 SGTC_3134 9127454 49.47 µM -0.579594516579866 0.30018730892721 no 2363 0.281094045849933 802 24262820 SGTC_2411 st077133 39.94 µM -0.579874935627901 0.300096446135323 no 2364 0.28099947962587 811 1403142 YNL221C POP1 SGTC_749 1000-0129 128 µM -0.580071324571796 0.300032818608648 no 2365 0.280933260180904 805 708470 SGTC_763 3453-1109 128 µM -0.584143884223465 0.298714738980893 no 2366 0.279561755989912 797 1560353 SGTC_3341 9147222 25.867 µM -0.584374691388097 0.298640117365631 no 2367 0.279484125164393 804 1939759 SGTC_3310 9130229 44.1445 µM -0.586306031168722 0.298016033840051 no 2368 0.278834939389747 805 7761258 SGTC_1223 0764-0573 147 µM -0.586416369669799 0.297980397561026 no 2369 0.278797873220964 786 1609797 SGTC_1976 st070609 63.5 µM -0.586571427226551 0.297930321548862 no 2370 0.278745788569822 782 682556 SGTC_1710 st031758 61.5 µM -0.586610364382397 0.297917747353314 no 2371 0.278732710117891 796 5394341 SGTC_2347 9049783 174.81 µM -0.586908248196232 0.297821558058642 no 2372 0.27863266495163 826 6467988 YPL169C MEX67 SGTC_1511 0906-3109 28.5 µM -0.590456106277425 0.296677014211244 no 2373 0.277442452484297 776 2882180 SGTC_1628 st004252 77.7 µM -0.590783247716041 0.296571579444439 no 2374 0.277332830463519 774 692968 SGTC_2695 st077686 51.995 µM -0.593114311832103 0.295820795730421 no 2375 0.276552326525651 773 2876092 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.593567041419368 0.295675082944858 no 2376 0.276400865264295 805 5355888 SGTC_1642 st009582 77.7 µM -0.593856231658649 0.29558202320573 no 2377 0.276304137599559 799 6739311 SGTC_2458 5808907 16.39 µM -0.594318302198966 0.295433359543226 no 2378 0.276149619817373 805 2731747 SGTC_1764 st044502 93.5 µM -0.595773327944239 0.294965453556622 no 2379 0.275663332069457 786 8407 SGTC_775 4577-0580 57.3 µM -0.59746271452784 0.294422610786035 no 2380 0.275099246684211 809 2006902 SGTC_3026 9090633 49.47 µM -0.597635549279264 0.294367100610123 no 2381 0.275041569312373 792 25236842 SGTC_2692 st077426 47.7 µM -0.598441209114166 0.294108406718782 no 2382 0.274772787992885 813 25238571 SGTC_1759 st043059 70 µM -0.600482124813156 0.293453548167595 no 2383 0.274092485141499 816 669426 SGTC_572 0960-0087 17.7 µM -0.602541926791634 0.292793315323566 no 2384 0.273406731715637 812 6796365 SGTC_2052 5265182 7.135 µM -0.603094095133634 0.292616444887321 no 2385 0.273223047208886 795 1239884 SGTC_357 1325-0123 420 µM -0.603442677151899 0.292504812741077 no 2386 0.273107119286441 816 1098503 SGTC_1725 st036284 20.55 µM -0.603641568014903 0.292441127522451 no 2387 0.273040985076182 769 707914 SGTC_2753 fluvastatin 17.09 µM -0.603694888350551 0.292424055349033 no 2388 0.273023256610257 808 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2704 st078022 71.1 µM -0.605004643371182 0.292004841860959 no 2389 0.27258795572021 820 54697681 SGTC_2008 4012253 172 µM -0.605609458228392 0.291811353159229 no 2390 0.272387060087226 796 603940 SGTC_3330 9141424 71.43 µM -0.608827396122309 0.290782895729463 no 2391 0.27131942624856 777 27261020 SGTC_3137 9097352 49.47 µM -0.610100439202378 0.290376497762795 no 2392 0.270897637863844 847 44120435 SGTC_2303 7774051 200 µM -0.611663748889446 0.289877801098145 no 2393 0.270380125516909 828 2953184 SGTC_2989 9073649 71.4286 µM -0.612272311916323 0.289683777835357 no 2394 0.270178802733715 825 21367202 SGTC_3257 9139206 32.98 µM -0.612718893831503 0.289541436495881 no 2395 0.270031113709717 799 4910041 SGTC_2193 5925765 200 µM -0.614313001129065 0.289033606561466 no 2396 0.269504256447407 796 877370 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.615730473848381 0.288582398778351 no 2397 0.269036210562523 794 2724 A muscle relaxant with antifungal properties. SGTC_1649 st011737 51.3 µM -0.616281627637404 0.288407045977874 no 2398 0.268854331202402 784 1761035 SGTC_1928 4'-methoxychalcone 40.3 µM -0.616971236597921 0.288187713620517 no 2399 0.268626848980654 802 641818 SGTC_765 1319-0117 244 µM -0.619044197201106 0.287528876029716 no 2400 0.267943621616509 791 3487746 YGL099W LSG1 SGTC_2222 6885208 172.143 µM -0.61909167922135 0.287513793428559 no 2401 0.267927982268781 785 609514 SGTC_31 0508-1974 57.237 µM -0.619196046525453 0.287480642606841 no 2402 0.267893607997648 783 6810525 SGTC_1022 4477-0945 21.3 µM -0.619896394986749 0.287258233439125 no 2403 0.267662999672936 793 4648966 SGTC_777 1315-0167 517 µM -0.619904297197617 0.28725572440423 no 2404 0.26766039823115 803 4221767 SGTC_2150 5556613 200 µM -0.62081924125488 0.286965290204521 no 2405 0.267359280895934 818 743190 SGTC_2922 7999257 32.47 µM -0.62086764168317 0.286949930145774 no 2406 0.267343356586451 818 2988377 SGTC_1706 st031321 9.9705 µM -0.624070802230286 0.285934261941923 no 2407 0.266290544004832 803 6103185 SGTC_2470 5664817 21.68 µM -0.624989758738353 0.285643192111955 no 2408 0.265988889841798 808 2859561 SGTC_2952 9073731 13.78 µM -0.625010869611317 0.285636507121461 no 2409 0.265981962078639 815 16457353 SGTC_2639 lactacystin 53 µM -0.626826274337113 0.285061917868175 no 2410 0.265386559329921 793 3870 A proteasome inhibitor. SGTC_2942 9052777 62.25 µM -0.626887640399929 0.285042504680172 no 2411 0.265366444776504 839 6469503 SGTC_3268 9137683 49.47 µM -0.627646161299843 0.284802598238011 no 2412 0.26511788088467 859 1953228 SGTC_534 k292-0788 63.4 µM -0.628223513692857 0.284620056721575 no 2413 0.264928764391432 825 4146317 SGTC_2159 5658611 73.75 µM -0.628473826303389 0.284540932742715 no 2414 0.264846793760929 807 793844 SGTC_1147 3809-1045 12.3 µM -0.630024807138931 0.284050901048796 no 2415 0.264339176945883 797 325925 SGTC_2234 tolnaftate 200 µM -0.631115045695889 0.283706682478776 no 2416 0.263982652064192 814 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_926 2268-1401 59.4 µM -0.631924025427305 0.28345139430968 no 2417 0.263718261650264 817 2931578 SGTC_2403 6032726 181.2 µM -0.632138639557071 0.283383687428759 no 2418 0.263648144225491 792 2881040 SGTC_976 1348-1067 47.6 µM -0.63445032428525 0.282654884665241 no 2419 0.262893488056456 817 5310671 YGL099W LSG1 SGTC_1996 st072960 66.8 µM -0.635887271829863 0.282202313966862 no 2420 0.262424949640322 793 1719405 SGTC_1329 1447-1697 50.6 µM -0.636776161271684 0.28192253043764 no 2421 0.262135328028022 802 2840515 SGTC_1134 3477-0009 42.5 µM -0.637506701397835 0.281692688439692 no 2422 0.261897423128682 814 3973534 SGTC_1437 4092-1038 11.6 µM -0.637943609180703 0.2815552720191 no 2423 0.261755194343421 819 3977136 SGTC_1175 0741-0056 27.6 µM -0.639012433059261 0.281219241447662 no 2424 0.261407421857156 812 765927 SGTC_2512 diallyl trisulfide 49.23 µM -0.639380096091499 0.281103695605204 no 2425 0.261287847026116 836 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2525 harmine 47.85 µM -0.63953631768835 0.281054606625277 no 2426 0.26123704767613 800 5280953 A monoamine oxidase inhibitor SGTC_101 0490-5701 117.494 µM -0.639557734253656 0.281047877293777 no 2427 0.26123008394112 807 4661669 SGTC_3114 9122766 49.47 µM -0.639693640797092 0.281005175706924 no 2428 0.261185895270952 787 17176985 SGTC_1960 st011366 51.8 µM -0.640365545241132 0.280794110637549 no 2429 0.260967488630204 825 3972846 SGTC_49 0717-0965 32.132 µM -0.641857539255441 0.280325705455868 no 2430 0.260482842897371 837 5889349 YGL099W LSG1 SGTC_108 0509-0257 621.132 µM -0.642529895598386 0.280114745795645 no 2431 0.260264592384947 812 536624 SGTC_571 k831-0106 44.2 µM -0.645080759053032 0.279315082967842 no 2432 0.259437426014037 835 4783639 SGTC_2472 5377652 49.4 µM -0.645123830772883 0.279301590066859 no 2433 0.259423470850147 838 1610903 SGTC_1288 0973-0013 65.5 µM -0.646317780072095 0.278927692592609 no 2434 0.25903678771595 810 4315430 SGTC_1671 st016596 74.5 µM -0.649026241120589 0.278080414058395 no 2435 0.258160707509617 829 2829167 SGTC_1938 st074717 56.4 µM -0.649584387111559 0.27790596732463 no 2436 0.257980360410128 789 17250979 SGTC_1157 4092-0394 27.6 µM -0.649913570799988 0.277803107069559 no 2437 0.257874025832614 816 3659885 SGTC_1930 st074634 34.3 µM -0.651151418806698 0.277416482304454 no 2438 0.257474373564613 824 684253 YOR116C RPO31 SGTC_2851 9015922 71.43 µM -0.651360159260726 0.277351311028983 no 2439 0.257407011228667 829 2996893 SGTC_184 1494-0393 24.714 µM -0.65309199675499 0.276810899467166 no 2440 0.25684848575641 825 3090647 SGTC_3323 9138564 53.9225 µM -0.653144504265056 0.2767945228104 no 2441 0.256831561701956 816 43912313 YNL103W MET4 SGTC_1432 4049-0298 68.4 µM -0.653208301927357 0.276774625487481 no 2442 0.256810999422385 821 741646 SGTC_2486 5283202 22.39 µM -0.653687257285281 0.276625270459273 no 2443 0.256656657277888 809 1377751 SGTC_1624 st003710 6.25 µM -0.65470988874503 0.276306510480216 no 2444 0.256327278627486 831 24207033 SGTC_133 0724-0033 378.92 µM -0.655173297054428 0.276162122859917 no 2445 0.256178092342503 809 280309 SGTC_457 grayanotoxin iii 135 µM -0.656140855725858 0.275860772749068 no 2446 0.25586674958825 822 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2379 9035213 200 µM -0.656187178887486 0.27584634926424 no 2447 0.255851848593907 807 646551 SGTC_3157 9099274 49.47 µM -0.656803308703403 0.275654542271812 no 2448 0.255653698233858 810 17217662 SGTC_3263 9137018 49.47 µM -0.657826018838779 0.275336307830693 no 2449 0.255324966658754 824 43844957 SGTC_2061 5245884 80.95 µM -0.657876026900056 0.275320751571122 no 2450 0.255308898144825 831 573863 SGTC_1196 1588-0294 184 µM -0.658374561658978 0.275165693506723 no 2451 0.255148738624044 828 6144269 SGTC_3105 9121040 49.47 µM -0.658663093370197 0.275075971833012 no 2452 0.255056068796075 783 41448907 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.65988625843846 0.274695777141775 no 2453 0.254663411591224 823 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_33 0986-0033 35.816 µM -0.661562243895922 0.27417525406276 no 2454 0.254125905691118 789 2848082 SGTC_3120 9124077 49.47 µM -0.661978886391925 0.274045930003295 no 2455 0.2539923765349 837 18774327 YGL155W CDC43 SGTC_1897 st060201 15 µM -0.662144091348974 0.273994659433822 no 2456 0.253939440429615 821 611878 SGTC_18 0111-0177 500 nM -0.662234647860493 0.273966557664531 no 2457 0.253910426147993 825 721752 SGTC_2634 4'-methoxyflavone 100 µM -0.663695094400334 0.273513544345449 no 2458 0.253442739870472 806 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_685 1278-0033 54.9 µM -0.666032265407218 0.272789353727746 no 2459 0.252695238611942 836 3590572 SGTC_2141 5621638 7.665 µM -0.666362186242923 0.272687201859942 no 2460 0.252589813082004 815 2856238 SGTC_3280 9140961 49.47 µM -0.666418947623366 0.27266962900944 no 2461 0.252571677435065 844 4901226 SGTC_1112 tnp00069 1.16933 µM -0.667056104317896 0.272472409176045 no 2462 0.25236814861705 813 145826 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.668036276638815 0.272169153697933 no 2463 0.25205521819243 839 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_429 1112-0049 25.5 µM -0.668226239059184 0.272110400645121 no 2464 0.251994594362911 811 2836170 SGTC_1820 st053765 18.6 µM -0.669301091352168 0.27177808079954 no 2465 0.25165171538546 820 3690829 SGTC_2964 9083345 53.42 µM -0.670067234693384 0.271541330086306 no 2466 0.251407465384229 823 17741579 SGTC_109 0132-0036 33.701 µM -0.670385090699429 0.271443137582401 no 2467 0.251306168223862 797 67274 A color developer. SGTC_1241 0364-0022 50.8 µM -0.670515563375664 0.27140283690956 no 2468 0.251264594286167 832 4563895 SGTC_1482 3346-2049 8.48 µM -0.67074458845712 0.271332102374036 no 2469 0.251191626311639 802 3826804 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.671659693324399 0.27104956340523 no 2470 0.250900183453849 829 390807 SGTC_334 1502-1024 68.5 µM -0.672060174402607 0.27092596090365 no 2471 0.250772694452399 821 3296216 SGTC_2999 9069765 71.4286 µM -0.672303738051294 0.270850802378687 no 2472 0.25069517526589 803 2097066 SGTC_2587 piperic acid 92.2 µM -0.672308179375233 0.270849431977864 no 2473 0.25069376184019 807 5370536 SGTC_3136 9095672 49.47 µM -0.673646295043098 0.270436704909188 no 2474 0.250268106511858 814 17217380 SGTC_418 lividomycin a 100 µM -0.674839509603175 0.270068936273231 no 2475 0.249888867765686 825 72394 An antibiotic. SGTC_1709 st033179 39.1045 µM -0.67525165374667 0.269941964736759 no 2476 0.249757947124745 826 573381 SGTC_353 1988-1175 58.3 µM -0.676212960517083 0.26964592578162 no 2477 0.249452722509667 826 2788357 SGTC_897 1000-0139 31.4 µM -0.676290313053552 0.269622111775061 no 2478 0.249428170917723 831 6151020 SGTC_182 3448-4371 550.524 µM -0.677100393893685 0.269372780935986 no 2479 0.249171129508683 794 3491403 SGTC_188 3229-0966 278.469 µM -0.67745706043785 0.26926304094159 no 2480 0.249058002685082 827 5722370 SGTC_1644 st010134 20.9 µM -0.678291759318539 0.269006306515306 no 2481 0.248793361303825 837 3818134 SGTC_868 0527-0199 213 µM -0.679440670866366 0.268653128477483 no 2482 0.248429343760961 821 2849450 SGTC_2218 6965428 192.983 µM -0.679444907303074 0.268651826618432 no 2483 0.248428002027062 823 675684 SGTC_2321 7390090 138.78 µM -0.679707534710575 0.268571127279144 no 2484 0.248344832096469 834 649046 SGTC_2744 captopril 92.04 µM -0.682184785368916 0.267810525328381 no 2485 0.247561057000415 792 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_409 arachidonic acid 100 µM -0.687304406746298 0.266242070255611 no 2486 0.245945461220816 833 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2969 9091408 28.7 µM -0.688671985920756 0.265823884911506 no 2487 0.245514854593175 829 4286311 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.689746044736539 0.265495687280596 no 2488 0.245176952244322 846 442882 SGTC_1668 st014914 51.6 µM -0.690614294451445 0.265230528596721 no 2489 0.244903980993753 839 2839556 SGTC_292 k038-0015 474 µM -0.693051941249585 0.264486804052206 no 2490 0.244138477918678 838 46368540 SGTC_555 4296-0685 37 µM -0.693292111302004 0.264413585787917 no 2491 0.244063126333625 849 2908540 YHR072W ERG7 SGTC_1025 k007-0731 70 µM -0.694145568077899 0.264153484371743 no 2492 0.243795462073513 837 6256118 SGTC_3237 9133362 49.47 µM -0.69666314643716 0.263386981514306 no 2493 0.243006813771185 841 43845137 SGTC_2203 7227154 166.4 µM -0.699362014558233 0.262566546124958 no 2494 0.242162910163151 828 896304 SGTC_3057 9095946 49.47 µM -0.701221377458913 0.262002075867092 no 2495 0.241582435388801 849 24540043 SGTC_1757 st041620 31.8375 µM -0.702248274847129 0.261690594552253 no 2496 0.241262172286647 853 5289815 SGTC_2466 5983409 37.09 µM -0.702496390456199 0.26161536396098 no 2497 0.241184825980425 844 2879657 SGTC_403 arphamenine a 50 µM -0.703323067412102 0.261364789175362 no 2498 0.240927219176677 840 5487158 An arginine aminopeptidase inhibitor. SGTC_1100 amiodarone 5.07 µM -0.704158155560228 0.261111790080768 no 2499 0.240667143328066 812 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_2978 9011784 42.97 µM -0.704867936476934 0.260896853190431 no 2500 0.240446212756883 820 2994934 SGTC_782 0083-0095 30.5 µM -0.706304774250955 0.260462026613835 no 2501 0.239999312532179 835 3591729 An indicator and reagent. SGTC_2607 solasodine 47.35 µM -0.706694093187496 0.260344272305198 no 2502 0.239878300541805 852 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.707700017017768 0.260040145278 no 2503 0.239565783425234 854 688751 SGTC_628 1636-0253 16 µM -0.708960920954737 0.25965918746298 no 2504 0.239174364048418 846 4456143 SGTC_17 0960-0276 49.807 µM -0.709262008635503 0.259568262253344 no 2505 0.239080949840686 839 6821114 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.71015096754163 0.259299902274165 no 2506 0.238805261559776 845 616764 SGTC_2108 5365811 200 µM -0.711245434091252 0.258969700427376 no 2507 0.238466079222781 829 780283 SGTC_215 1287-0124 461.5 µM -0.71280790539708 0.258498678157981 no 2508 0.23798231654824 844 5560863 SGTC_1042 0350-0096 82 µM -0.714211877784242 0.258075815749938 no 2509 0.237548086629325 847 3122515 SGTC_1790 st045711 43.5 µM -0.714220697536622 0.258073160463222 no 2510 0.237545360172749 800 585119 SGTC_2699 st077704 54.6 µM -0.71482063479695 0.257892575795321 no 2511 0.237359941446633 841 645852 SGTC_755 1995-0008 37.3 µM -0.714916934970959 0.257863594980681 no 2512 0.237330185978956 815 689533 SGTC_2468 5987765 72.9 µM -0.715943420432891 0.257554786928169 no 2513 0.237013142998607 825 26772094 SGTC_2313 7726885 200 µM -0.715990900131744 0.257540507776862 no 2514 0.236998483929339 851 726423 SGTC_1498 4478-3555 97.6 µM -0.716399923449592 0.257417514215842 no 2515 0.236872221098205 827 3437919 SGTC_1792 st045773 43.6 µM -0.717517638646665 0.257081572286098 no 2516 0.236527378397638 799 2919270 SGTC_11 0438-0307 1.3 µM -0.71936320550468 0.256527365808387 no 2517 0.235958580701839 848 4011476 SGTC_2608 thymoquinone 42.66 µM -0.719783457378021 0.256401255147176 no 2518 0.235829165894853 840 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2425 5628681 7.85 µM -0.720975165706577 0.256043818893253 no 2519 0.23546239720042 852 5714958 SGTC_2365 9042475 200 µM -0.721037111189413 0.256025246320787 no 2520 0.235443341024773 844 6464479 SGTC_2836 9010338 19.48 µM -0.722381685998185 0.255622287460194 no 2521 0.235029921730863 843 2994051 SGTC_3017 9080681 49.47 µM -0.722641297634665 0.255544521992905 no 2522 0.234950144602927 848 16451914 SGTC_645 0845-0943 5.41 µM -0.722891814876978 0.255469492427708 no 2523 0.234873176316851 837 1885106 SGTC_3049 9092223 49.47 µM -0.722949867360936 0.255452107432418 no 2524 0.234855342407003 840 8623917 SGTC_2684 capsaicin 100 µM -0.72315051666959 0.255392023683148 no 2525 0.234793708058107 857 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_52 0329-0193 875 nM -0.723664200863445 0.255238236371602 no 2526 0.234635958133107 859 3739292 SGTC_832 4083-0019 164 µM -0.729292324651375 0.253556459339671 no 2527 0.232911433143138 859 1990758 SGTC_2710 st078562 53.7235 µM -0.729578680457043 0.253471047364986 no 2528 0.232823878901795 854 17250908 SGTC_2270 7924575 90.91 µM -0.729823265439857 0.253398106438688 no 2529 0.232749110711047 854 1262135 SGTC_567 1080-0542 68.4 µM -0.732415615722681 0.252625685973109 no 2530 0.231957465198395 810 5950415 SGTC_2868 9035608 32.47 µM -0.732939964815792 0.252469601088893 no 2531 0.231797523276683 846 6462614 SGTC_2506 ethyl hematommate 54.16 µM -0.735210625455788 0.251794272324225 no 2532 0.231105614447476 861 3940691 An allergen. SGTC_1714 st033236 13.627 µM -0.735544841359172 0.251694952050823 no 2533 0.231003870589288 861 2916566 SGTC_2875 9039966 71.43 µM -0.736078671711769 0.251536354481878 no 2534 0.230841410870357 863 6463691 SGTC_759 3486-0358 89.3 µM -0.737759462621349 0.251037347345049 no 2535 0.230330315453583 857 875103 SGTC_3276 9139060 49.47 µM -0.737836835766729 0.251014388781677 no 2536 0.230306803048125 874 4870619 SGTC_2624 nerol 100 µM -0.738955383423395 0.250682611648539 no 2537 0.229967045107937 868 637566 A natural product oil. SGTC_648 0375-0473 33.3 µM -0.739050241830426 0.250654485983884 no 2538 0.229938244853678 854 1713139 SGTC_678 1218-2179 85.9 µM -0.740522829968223 0.250218075780117 no 2539 0.229491406843245 874 6820081 YOR116C RPO31 SGTC_2954 9074818 52.69 µM -0.741155609981293 0.250030671530711 no 2540 0.229299547423429 855 16648742 SGTC_1931 st074438 57.1 µM -0.741364952338141 0.249968689056704 no 2541 0.229236094450573 874 2787313 SGTC_2275 7947463 200 µM -0.744966263649281 0.248903684052982 no 2542 0.228146057389509 842 1225414 SGTC_2026 5148700 152 µM -0.747414973599928 0.248180916119536 no 2543 0.227406554824653 858 79838 SGTC_252 miconazole 1.30953 nM -0.747830315686147 0.248058433736116 no 2544 0.227281256920008 847 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_255 tunicamycin 200.472 nM -0.749092579936879 0.247686396096343 no 2545 0.226900703493112 851 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_40 0327-0103 19.753 µM -0.750365699771581 0.24731146095531 no 2546 0.226517241590168 856 409036 SGTC_1218 1348-1416 30.7 µM -0.752627111249302 0.246646221721079 no 2547 0.225837010624915 845 6787668 SGTC_129 0088-0017 176.636 µM -0.753919223315999 0.246266551888135 no 2548 0.225448863434688 848 182446 SGTC_1682 st012968 530 nM -0.755976870355586 0.24566258722606 no 2549 0.224831531717009 848 24207270 SGTC_1248 0469-0687 58.6 µM -0.7599355330058 0.244502873479857 no 2550 0.223646560315246 854 4017482 SGTC_1821 st053465 65.6 µM -0.761074180830745 0.244169846836693 no 2551 0.223306380500658 861 675086 SGTC_2386 9075165 157.42 µM -0.762311993963838 0.243808094410461 no 2552 0.222936908574502 849 16452277 SGTC_2214 7179297 48.276 µM -0.762813572269687 0.243661589927857 no 2553 0.222787292845292 849 769744 SGTC_3273 9137859 49.47 µM -0.762850681735388 0.243650752625668 no 2554 0.222776225741153 898 2377234 SGTC_2406 ethylparaben 405.7 µM -0.764654259582098 0.243124356706155 no 2555 0.222238724990936 864 8434 A possible steroid mimic. SGTC_999 SEC7.066 22.7 µM -0.76650301404835 0.242585414336503 no 2556 0.221688529577036 860 740511 YDR170C SEC7 SGTC_1634 st006576 41 µM -0.766539310390339 0.242574839834467 no 2557 0.22167773546196 848 3915356 SGTC_2146 5545642 200 µM -0.767152778389254 0.2423961510918 no 2558 0.221495342565192 854 825326 SGTC_1283 0922-0125 16.4 µM -0.767776394167969 0.242214579660167 no 2559 0.221310020546402 842 3360884 SGTC_3286 9117135 37.221 µM -0.767786949840971 0.24221150691418 no 2560 0.221306884444615 859 3438150 SGTC_882 0843-0131 351 µM -0.76784159412039 0.242195600356236 no 2561 0.221290649976863 862 5425421 SGTC_2368 9071271 200 µM -0.768463388577261 0.242014640336972 no 2562 0.221105966778084 870 27209959 SGTC_2976 9009005 19.48 µM -0.768844940288279 0.241903634161557 no 2563 0.220992683310504 824 2993148 SGTC_3008 9078912 71.4286 µM -0.769675852362007 0.241661989608231 no 2564 0.220746098829266 882 16648731 SGTC_1151 3909-8316 15.3 µM -0.770209459904125 0.241506875819933 no 2565 0.220587826643754 860 800431 SGTC_1750 st081859 2.357 µM -0.77099811145075 0.241277722618827 no 2566 0.22035402549953 864 5291695 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.771016365242634 0.241272420136124 no 2567 0.220348615720654 858 23665772 A membrane-active detergent. SGTC_180 1486-1293 102.781 µM -0.77160515489168 0.241101418577843 no 2568 0.220174160114346 859 4140536 SGTC_1261 0712-0010 12.7 µM -0.772887139980887 0.240729321030181 no 2569 0.219794588081168 860 2840123 SGTC_2832 7992762 51.95 µM -0.77331428754526 0.24060541044088 no 2570 0.219668201079128 860 2985177 SGTC_2857 9024691 58.44 µM -0.774161410374863 0.240359772611052 no 2571 0.219417672744424 878 16478292 SGTC_2818 7996756 12.99 µM -0.774753992492747 0.240188024476165 no 2572 0.219242519976221 887 2241621 SGTC_3001 9076041 71.4286 µM -0.775186555703528 0.240062696880508 no 2573 0.219114715640321 852 16004211 SGTC_2343 7990716 14.84 µM -0.7762131238536 0.239765409541137 no 2574 0.218811579214757 881 6456862 SGTC_1130 3454-2858 15.9 µM -0.776947831934776 0.239552766332798 no 2575 0.218594774700754 868 715628 YIL048W NEO1 SGTC_3307 9126885 69.2785 µM -0.777194001875194 0.239481541523967 no 2576 0.218522160248202 863 24824909 SGTC_1135 dihydrocapsaicin 536.708 nM -0.777249596041723 0.239465457960608 no 2577 0.218505763174574 892 107982 A Capsaicinoid. SGTC_3279 9140807 49.47 µM -0.77752475327095 0.239385862812661 no 2578 0.218424618088962 876 45595718 SGTC_469 w7 172 µM -0.779825555891184 0.238720872060346 no 2579 0.217746780857082 852 45115570 A P450 inhibitor. SGTC_448 monastrol 171 µM -0.78218090707838 0.238041163642726 no 2580 0.217054131791365 874 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_132 0417-1715 25.805 µM -0.786460015991603 0.236809015090241 no 2581 0.215799017458822 873 6769098 SGTC_186 3455-3465 67.277 µM -0.786771545594957 0.236719448822822 no 2582 0.215707806628778 859 755278 SGTC_701 4424-0219 185 µM -0.78688075783771 0.236688054186395 no 2583 0.215675836341776 862 2911779 SGTC_190 3970-0790 3.722 µM -0.788469130720341 0.23623171244105 no 2584 0.2152111740233 861 2832352 SGTC_1612 st002233 45.4 µM -0.788577003771996 0.236200737943938 no 2585 0.215179637944759 864 1035021 SGTC_920 mycophenolic acid 780.421 nM -0.789458694832015 0.235947654446544 no 2586 0.214921981112023 871 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.789487101529452 0.235939502980704 no 2587 0.214913682795373 855 97141 SGTC_1984 st072354 53.1 µM -0.789762429107651 0.235860504185579 no 2588 0.21483326227173 858 5762938 SGTC_3168 9103419 49.47 µM -0.790356072479252 0.23569022175849 no 2589 0.214659924278607 859 16649256 SGTC_1285 0929-0069 65.5 µM -0.790954048710713 0.235518765047828 no 2590 0.21448540333498 864 1206237 SGTC_2937 9044753 11.33 µM -0.791023667916864 0.235498807724435 no 2591 0.214465090148418 845 6465530 YGL099W LSG1 SGTC_665 3914-0008 307 µM -0.792500371709906 0.235075709721985 no 2592 0.214034487557911 875 1069549 SGTC_2591 skatole 100 µM -0.792748358538996 0.235004698939697 no 2593 0.213962224690268 876 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2120 5538279 151.968 µM -0.793845575944983 0.23469065408803 no 2594 0.213642668211029 862 2058197 SGTC_478 N-arachidonylglycine 10 µM -0.794536082567482 0.23449313676329 no 2595 0.213441705879232 828 5283389 SGTC_1226 3909-7979 35.4 µM -0.795210258126041 0.234300379649518 no 2596 0.213245602820482 872 6615510 SGTC_2197 6588183 93.1375 µM -0.795273234717247 0.234282378157882 no 2597 0.213227289662108 847 884136 SGTC_2371 9071574 200 µM -0.7960149768647 0.234070413106049 no 2598 0.213011665185719 886 45596039 SGTC_2716 st080858 38.6235 µM -0.798052025225575 0.233488839674065 no 2599 0.212420149997821 850 5296050 SGTC_1669 st015249 58.4 µM -0.800123963944073 0.232898128215449 no 2600 0.211819489056668 880 722793 SGTC_2013 4024628 200 µM -0.803112403521577 0.232047585751531 no 2601 0.210954884599606 889 5230760 SGTC_168 3970-0862 530.542 µM -0.804554323038532 0.231637819044071 no 2602 0.210538454799189 867 3135186 SGTC_207 4185-0010 4.486 µM -0.805699739956849 0.231312600475481 no 2603 0.210207999747318 859 3761753 SGTC_283 0987-0079 11.7 µM -0.807267452588846 0.230867892486291 no 2604 0.209756205690645 866 411556 SGTC_704 1310-0270 142 µM -0.807822552061654 0.230710543734416 no 2605 0.209596370324338 878 5718033 SGTC_891 0929-0073 133 µM -0.808693465087699 0.230463795101223 no 2606 0.209345744003505 891 5603632 SGTC_2794 7785382 27.27 µM -0.810697049435863 0.229896696448736 no 2607 0.208769834098252 861 2205081 SGTC_286 k060-0067 22.9 µM -0.810900711855244 0.229839095187085 no 2608 0.208711345731825 867 5985051 SGTC_174 3553-0389 74.3 µM -0.812781460750559 0.229307550342292 no 2609 0.208171683327477 869 738071 SGTC_1076 itraconazole 331 nM -0.813709431094144 0.229045537741744 no 2610 0.207905715021313 867 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.814321061153048 0.22887293575129 no 2611 0.207730523694655 890 521171 SGTC_364 0083-0097 67.7 µM -0.814595206049804 0.228795595766156 no 2612 0.207652027729283 895 5207356 SGTC_1883 5-benzylidenerhodanine 20 µM -0.815899118510181 0.228427945316859 no 2613 0.207278918176447 850 1273210 SGTC_662 k832-1615 104 µM -0.817141473092151 0.228077960714465 no 2614 0.206923792244975 869 5878478 SGTC_986 1493-0483 84 µM -0.819519540764057 0.22740887538023 no 2615 0.206245028912322 870 40079 SGTC_3197 9113331 49.47 µM -0.820321739911554 0.227183420906752 no 2616 0.206016358111016 870 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2111 5486399 200 µM -0.820641801561936 0.22709350418693 no 2617 0.205925164947572 861 689674 SGTC_1064 honokiol 6.76 µM -0.821245514767721 0.226923954266451 no 2618 0.205753217915346 880 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_699 0375-0592 111 µM -0.822140125325256 0.226672838575761 no 2619 0.205498575465681 829 762578 SGTC_1990 st072050 59.8 µM -0.823021480149422 0.226425597181569 no 2620 0.205247889213915 865 17233948 SGTC_1431 4049-0260 9.09 µM -0.823675409695459 0.226242252548474 no 2621 0.205062007644367 883 3854841 SGTC_1442 4112-3290 3 µM -0.823799170895637 0.22620756260706 no 2622 0.205026839390084 892 704353 SGTC_146 3448-8650 53.125 µM -0.824312753980752 0.226063638726327 no 2623 0.204880936806027 918 2891488 YIL048W NEO1 SGTC_650 1328-0195 38 µM -0.82625339483277 0.225520271061588 no 2624 0.204330182461574 882 2780821 SGTC_2653 dihydrofissinolide 100 µM -0.826364942138144 0.225489060974866 no 2625 0.204298552120831 891 6857746 SGTC_2460 5552655 174.22 µM -0.826785258981626 0.225371481487204 no 2626 0.204179393317871 875 5401989 SGTC_1509 1326-1131 80 µM -0.82771013102877 0.225112879934459 no 2627 0.203917340132271 847 768313 SGTC_1321 1326-2144 215 µM -0.828551928787511 0.224877652826831 no 2628 0.20367899953061 900 3513030 SGTC_1193 1488-0126 41.5 µM -0.829646079093327 0.224572118143068 no 2629 0.203369458010098 871 1384710 SGTC_7 0192-1582 4.227 µM -0.830816627548461 0.224245510658117 no 2630 0.20303861397143 900 252616 SGTC_2140 5586273 200 µM -0.83119787351907 0.224139193318089 no 2631 0.202930927959189 880 854421 SGTC_3265 9137266 49.47 µM -0.831458636973079 0.224066491198475 no 2632 0.202857292858629 840 17224265 SGTC_2419 paclitaxel 166.5 µM -0.833456808045775 0.223509836178541 no 2633 0.202293573766766 883 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.836668045228179 0.222616892500354 no 2634 0.201389592836341 899 5377381 SGTC_799 1310-0557 151 µM -0.836729460586288 0.22259983467106 no 2635 0.201372327703913 896 5354492 SGTC_1518 st038567 90.8 µM -0.840270921723396 0.221617471489909 no 2636 0.200378250674619 902 77966 SGTC_2830 7992007 71.43 µM -0.840447498640895 0.22156855588573 no 2637 0.200328763366256 884 1952075 SGTC_754 3474-0146 171 µM -0.841558383140584 0.22126095855122 no 2638 0.200017596193104 868 24762078 SGTC_3036 9090181 49.47 µM -0.842162384343994 0.221093816754636 no 2639 0.199848532893301 893 25236586 SGTC_2081 5214970 32.255 µM -0.843429339290122 0.220743454381076 no 2640 0.199494184484323 893 2063512 SGTC_1979 st071809 45.3 µM -0.84347763707677 0.220730104457308 no 2641 0.199480683800903 904 4976333 SGTC_3055 9094636 49.47 µM -0.844086678172185 0.220561799942819 no 2642 0.199310485702531 891 25236176 SGTC_297 0986-0032 24 µM -0.845172227081281 0.220261998015774 no 2643 0.199007343187476 880 2847425 SGTC_2908 7930301 100 µM -0.846150919499611 0.21999190762757 no 2644 0.198734278936 862 2223178 SGTC_1619 st003326 88.7 µM -0.846330734054399 0.21994230475884 no 2645 0.198684133587087 833 2849032 SGTC_3249 9135183 49.47 µM -0.847255373001056 0.219687339213735 no 2646 0.198426397652264 859 4902779 SGTC_1502 4534-4282 27.7 µM -0.851311206338277 0.218570966001763 no 2647 0.197298250726738 905 3278949 SGTC_3258 9138477 49.47 µM -0.852668844560436 0.218198005287302 no 2648 0.196921486419671 903 4970355 SGTC_1032 k061-1018 98.7 µM -0.853593769329159 0.217944126703455 no 2649 0.196665056003264 912 4005393 SGTC_2918 7977171 22.06 µM -0.853785643358432 0.217891481374498 no 2650 0.19661188530457 866 2236483 SGTC_1477 0139-0234 16 µM -0.857856603126572 0.216776243712199 no 2651 0.19548582490235 883 620880 SGTC_3150 9097574 49.47 µM -0.858836243933642 0.216508365077569 no 2652 0.195215434149389 871 17217476 SGTC_473 2-arachidonoylglycerol 10 µM -0.859644574850973 0.216287474703065 no 2653 0.194992497879596 872 5282280 An endocannabinoid. SGTC_39 0986-0283 58.349 µM -0.860260369457029 0.216119285786973 no 2654 0.194822766713117 853 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_284 0988-0104 32.6 µM -0.860597286472939 0.216027297386474 no 2655 0.194729940484297 906 4666532 SGTC_2332 7982454 138.89 µM -0.860891750249842 0.215946918564554 no 2656 0.194648832865511 906 2981748 SGTC_134 0269-0018 6.916 µM -0.861137498982882 0.215879850597148 no 2657 0.194581159141696 890 4378915 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.861603019238852 0.215752837269216 no 2658 0.194453004494864 873 17037758 SGTC_144 4161-2749 112.381 µM -0.861783722105692 0.215703545668937 no 2659 0.194403272036955 881 797501 YMR168C CEP3 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.862047551218375 0.215631590859473 no 2660 0.194330675749989 903 5282362 SGTC_2364 9055074 200 µM -0.86348041034891 0.215241046536031 no 2661 0.193936692765902 898 6470630 SGTC_3019 9081971 49.47 µM -0.864810607034528 0.214878851919484 no 2662 0.193571374179538 901 16451803 SGTC_1525 8-methoxypsoralen 92.5 µM -0.867396869555248 0.214175661734851 no 2663 0.192862298242851 908 4114 Related to psoralen; DNA damaging agent. SGTC_2045 5106652 78.05 µM -0.867567956892398 0.214129191317987 no 2664 0.192815447223437 869 673349 SGTC_1194 1488-0194 225 µM -0.868314952137737 0.213926362637541 no 2665 0.192610969487889 892 1391452 SGTC_863 0466-0191 129 µM -0.868420213268877 0.213897790490669 no 2666 0.192582166631472 903 765160 YPR165W RHO1 SGTC_2898 9056270 58.44 µM -0.870718004640394 0.213274630415214 no 2667 0.191954072615119 836 19154699 SGTC_1235 benzylparaben 21.5 µM -0.871371619636071 0.213097563874808 no 2668 0.191775638323975 902 7180 SGTC_2858 9025781 8.96 µM -0.872529502983957 0.21278409991359 no 2669 0.191459790199302 868 4894980 YPL153C RAD53 SGTC_481 bay k-8644 50 µM -0.87287619125703 0.212690296320747 no 2670 0.191365282399979 909 2303 A calcium channel antagonist. SGTC_192 3455-0609 60.9 µM -0.874296103632391 0.212306362071356 no 2671 0.190978510346811 891 3769639 SGTC_254 nsc-64875 3.808 µM -0.875201134387426 0.212061859667519 no 2672 0.190732238052276 892 56993 SGTC_2432 5630864 12.22 µM -0.877060365627625 0.211560088104761 no 2673 0.190226925447399 909 5714970 SGTC_787 4152-0075 138 µM -0.878456401816701 0.211183781509881 no 2674 0.189848043843902 881 9566539 SGTC_1690 st023502 41.2 µM -0.878747468224619 0.211105372950563 no 2675 0.189769107462216 883 24207482 SGTC_3208 9114115 49.47 µM -0.879627259418599 0.21086847525531 no 2676 0.189530633328871 888 650895 SGTC_1578 josamycin 24.2 µM -0.880981507767025 0.210504127293666 no 2677 0.189163914507283 881 5282165 A P450 substrate. SGTC_1590 st077108 57.8 µM -0.883890113507531 0.20972284401456 no 2678 0.188377767326966 881 5489485 SGTC_604 1000-0114 314 µM -0.884557676101191 0.209543770270491 no 2679 0.188197621139507 910 1572745 SGTC_2327 6189656 200 µM -0.884640876217095 0.209521458134825 no 2680 0.188175176489742 915 5349088 SGTC_2082 5219693 150 µM -0.884720164663546 0.209500196309135 no 2681 0.188153788616747 882 2834649 SGTC_1367 1812-0510 76.9 µM -0.885231331969112 0.209363153215037 no 2682 0.188015938446615 886 1142582 YDR527W RBA50 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.885944789546807 0.209171964667237 no 2683 0.187823639469366 869 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2865 9030313 51.95 µM -0.886933579008349 0.208907164168181 no 2684 0.187557330899599 903 42562754 SGTC_2750 bromebric acid 70.15 µM -0.888391307841091 0.208517140819556 no 2685 0.18716514967101 912 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2291 7917025 104.35 µM -0.888655253135935 0.208446566744396 no 2686 0.18709419320591 891 2964612 SGTC_1554 st069299 38.7 µM -0.889976666246564 0.208093457246701 no 2687 0.186739207687718 878 24207999 SGTC_3025 9087895 49.47 µM -0.890746813958666 0.207887820455975 no 2688 0.186532507003288 908 17173641 SGTC_909 3448-9333 149 µM -0.891635003716101 0.207650814367903 no 2689 0.186294300906224 912 3344074 SGTC_76 0433-0009 400.328 µM -0.892420150426352 0.207441437460859 no 2690 0.186083887235268 956 2841569 SGTC_2783 7738165 71.43 µM -0.892902571600734 0.20731285099845 no 2691 0.185954674927215 899 17201110 SGTC_281 1672-3440 14.9 µM -0.893138182468178 0.20725006747245 no 2692 0.185891588834356 896 6833000 SGTC_3239 9133757 49.47 µM -0.894612861510975 0.206857363385615 no 2693 0.185497037060375 920 17036923 SGTC_1143 3454-2408 5.08 µM -0.894992907151114 0.206756229416565 no 2694 0.185395439785181 860 X1143 SGTC_1382 3002-2117 298 µM -0.895412524084498 0.206644599139987 no 2695 0.185283304085069 949 1497314 SGTC_2079 5212404 121 µM -0.896010562524889 0.206485565265546 no 2696 0.185123560982979 886 758462 SGTC_160 3453-0671 289.699 µM -0.89629165940769 0.20641083939791 no 2697 0.185048506262952 913 5322268 SGTC_1741 st038134 10.228 µM -0.896374544310408 0.206388808608226 no 2698 0.185026379057151 919 1272587 SGTC_1575 cyproterone acetate 48 µM -0.898633888360751 0.205788812247935 no 2699 0.184423850945158 917 9880 An androgen receptor antagonist and liver toxin. SGTC_1394 3474-0001 65.7 µM -0.903092873161965 0.204607715856669 no 2700 0.183238303066785 880 5017666 YIL048W NEO1 SGTC_83 0170-0301 39.027 µM -0.903347620490526 0.204540360372442 no 2701 0.18317071508083 897 3089716 SGTC_1670 st016595 4.04 µM -0.904558820054814 0.204220298372354 no 2702 0.182849579865388 926 597879 SGTC_3289 9119912 71.43 µM -0.905733236856313 0.203910241273409 no 2703 0.182538532949979 916 17014829 SGTC_2286 7945697 125 µM -0.906347029932584 0.203748305801912 no 2704 0.182376100054702 911 1245733 SGTC_1330 1469-0054 61.8 µM -0.906910779381737 0.203599640779818 no 2705 0.182226990188281 902 7102664 SGTC_2202 7226349 200 µM -0.908719294915851 0.203123158284767 no 2706 0.181749158280708 890 844334 SGTC_1658 st012944 20 µM -0.909636084037307 0.202881869939635 no 2707 0.181507231068403 908 24207260 SGTC_3344 9148862 3.898 µM -0.909787718636959 0.20284197796535 no 2708 0.181467236355339 918 4905352 SGTC_721 1187-1332 279 µM -0.910004515864535 0.202784951170696 no 2709 0.181410064114766 927 25730 SGTC_1728 st035614 33.7865 µM -0.910117427301076 0.202755254504971 no 2710 0.181380292371096 904 15945546 SGTC_1863 st057641 20.1 µM -0.911267515678094 0.202452919560927 no 2711 0.18107721893589 925 3921635 SGTC_3298 9116858 71.43 µM -0.911662426497364 0.20234916770547 no 2712 0.180973224516878 955 2506942 SGTC_1308 1187-1617 41.4 µM -0.911675616367007 0.202345702982216 no 2713 0.18096975178924 906 2882570 SGTC_124 0136-0217 7.121 µM -0.912818196759004 0.202045703921122 no 2714 0.180669083167546 896 3976905 SGTC_2477 5967686 25.23 µM -0.91530543298898 0.20139356941728 no 2715 0.180015653862074 924 776118 SGTC_3054 9094397 49.47 µM -0.916052731533774 0.201197880130906 no 2716 0.179819619073571 918 2598354 SGTC_1738 st035555 74 µM -0.918966004822487 0.200436093101656 no 2717 0.179056676884872 913 5331140 SGTC_406 estrone 100 µM -0.920169274500776 0.20012195832377 no 2718 0.178742153950156 889 5870 A steroid. SGTC_35 0133-0054 64.071 µM -0.920528571632469 0.200028214874187 no 2719 0.178648304668679 912 99677 SGTC_3260 9137109 49.47 µM -0.921270945847064 0.199834607244306 no 2720 0.178454493034633 881 17478346 SGTC_3046 9092212 49.47 µM -0.92266397015409 0.199471617509603 no 2721 0.178091173800414 930 25236637 SGTC_504 lovastatin 124 µM -0.922932934519645 0.199401577394098 no 2722 0.178021078070688 918 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_209 4077-0173 175.592 µM -0.922934745994807 0.19940110572408 no 2723 0.178020606034888 897 15993494 SGTC_1563 conessine 56.1 µM -0.926037422196076 0.198594220298493 no 2724 0.177213266386569 913 441082 An anti-amoebic, histamine inhibitor. SGTC_1388 3346-4487 254 µM -0.928107174274914 0.198057054939436 no 2725 0.176675989258241 938 3345614 SGTC_2992 9074591 71.4286 µM -0.928159746323817 0.198043422285251 no 2726 0.176662355755565 916 17741321 SGTC_2063 5246145 200 µM -0.929395954278282 0.197723019937064 no 2727 0.176341961853659 925 711240 SGTC_1507 4075-3230 155 µM -0.929751581651864 0.197630905919083 no 2728 0.17624986035177 893 659771 SGTC_807 1315-0151 48 µM -0.931282231125721 0.197234735776224 no 2729 0.175853795480493 934 4011080 SGTC_2012 4023501 200 µM -0.931928823515495 0.197067526034735 no 2730 0.175686655255476 913 3477460 SGTC_883 0850-0245 24.6 µM -0.932078948120335 0.197028715866609 no 2731 0.175647863354261 886 6823229 YPR165W RHO1 SGTC_2165 5727197 32.143 µM -0.93309243121092 0.196766831571883 no 2732 0.175386123337541 913 1361712 SGTC_2206 7254556 146.969 µM -0.938639246406441 0.195337270767007 no 2733 0.173957997762275 896 4398905 SGTC_355 1311-2252 105 µM -0.939108024650649 0.195216744083209 no 2734 0.173837642312762 928 5338538 SGTC_1597 7-benzyloxygramine 47.5 µM -0.940777521430779 0.194787870136289 no 2735 0.173409441285272 907 260807 SGTC_562 3772-2733 112 µM -0.942809193624453 0.194266731390794 no 2736 0.172889254184057 919 2876874 YIL048W NEO1 SGTC_3072 9116419 49.47 µM -0.943772115810209 0.19402003167452 no 2737 0.172643056344775 918 17170162 SGTC_1108 betulinic acid 729.144 nM -0.944322518183018 0.19387910490424 no 2738 0.172502431116713 894 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_538 2922-0838 53.3 µM -0.944950723212505 0.193718333556936 no 2739 0.17234201697037 934 777039 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.945024338822568 0.193699499041323 no 2740 0.1723232252222 910 140250 A respiratory chain inhibitor. SGTC_1796 st049173 110.4 µM -0.945411527795339 0.193600455324733 no 2741 0.172224409584258 911 94134 SGTC_1530 rhein 70.4 µM -0.945803148533914 0.19350030937755 no 2742 0.172124499690742 910 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1880 MG-132 525 µM -0.946334752163864 0.193364417330175 no 2743 0.171988936702346 911 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_386 1509-0011 3.07 µM -0.948595528277665 0.192787153425511 no 2744 0.171413183099959 914 3107280 SGTC_57 miconazole 162.5 nM -0.948756725374163 0.192746033800562 no 2745 0.171372178014771 880 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2281 7943571 200 µM -0.948811323158817 0.192732107714877 no 2746 0.171358290930595 920 1244024 SGTC_737 1950-0117 57.9 µM -0.949781864465654 0.192484657398499 no 2747 0.171111551358714 917 5393513 SGTC_3063 1327-0034 4 µM -0.951671493996837 0.19200343284121 no 2748 0.170631805301332 898 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.952198897059582 0.191869252707935 no 2749 0.170498060135927 921 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2484 5809818 12.04 µM -0.952246786459102 0.191857071689687 no 2750 0.170485919095648 913 2870548 SGTC_34 0469-0683 81.75 µM -0.954784180515074 0.191212344229342 no 2751 0.169843424487371 911 3690923 SGTC_373 0844-0104 25.9 µM -0.958479619447171 0.19027574785735 no 2752 0.168910481828922 910 5375804 SGTC_980 1473-0395 201 µM -0.962955703315945 0.189145081157084 no 2753 0.167784876773902 921 768876 SGTC_3251 9135047 49.47 µM -0.963997424271702 0.188882535304086 no 2754 0.167523608614971 908 17682963 SGTC_1008 4106-0037 6 µM -0.965970354884841 0.188385911584654 no 2755 0.167029507669552 920 2905394 SGTC_927 2425-1185 123 µM -0.966472845051083 0.188259554170152 no 2756 0.16690381428994 925 730375 SGTC_1251 0490-5699 265 µM -0.967288232841123 0.188054626051665 no 2757 0.166699982255772 921 3883818 SGTC_344 k064-0035 6.43 µM -0.967415974248844 0.188022533799937 no 2758 0.166668063800142 899 5088750 SGTC_1640 st009078 66.4 µM -0.967759704078587 0.187936195941736 no 2759 0.166582196393489 910 690618 SGTC_2258 7960471 200 µM -0.968074579097577 0.187857127303639 no 2760 0.166503562292118 943 2974708 SGTC_1834 st055981 52.8 µM -0.969004666006991 0.187623692062539 no 2761 0.166271430565635 918 471719 YDL150W RPC53 SGTC_3089 9117425 49.47 µM -0.969738415973677 0.187439660415522 no 2762 0.166088448307339 924 9401657 SGTC_3075 9116269 49.47 µM -0.97042159848741 0.187268411916097 no 2763 0.16591819354744 904 17015205 YNL244C SUI1 SGTC_936 3005-4620 401 µM -0.971933105639409 0.186889877090859 no 2764 0.165541914399474 912 777207 SGTC_2359 9039622 200 µM -0.972542256377732 0.186737458165369 no 2765 0.165390426739909 929 6463596 SGTC_2972 9093619 59.92 µM -0.973157581205734 0.186583572532259 no 2766 0.165237494753744 907 25236256 SGTC_581 0958-0271 211 µM -0.973557687189195 0.186483552789384 no 2767 0.165138102081101 917 4591145 SGTC_859 0439-0102 54.6 µM -0.975590187294112 0.185975975041429 no 2768 0.164633794595954 915 610143 SGTC_371 0195-0006 7.36 µM -0.976229349686377 0.185816533753387 no 2769 0.164475410972784 895 3928593 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.976543526101359 0.185738192439406 no 2770 0.164397594675349 935 688798 SGTC_1650 st011916 45.8 µM -0.977185554617365 0.185578163445526 no 2771 0.164238649072845 944 242528 SGTC_3256 9138902 49.47 µM -0.977460412865321 0.185509679740659 no 2772 0.164170633488384 947 17228773 SGTC_856 0433-0016 11.3 µM -0.980678695410522 0.184708979608986 no 2773 0.163375606566418 919 3911780 SGTC_3167 9103034 49.47 µM -0.98219056279886 0.184333573918789 no 2774 0.163002987978323 929 5127859 SGTC_2300 7976697 71.57 µM -0.983704335529018 0.183958171109838 no 2775 0.162630453746836 903 2236109 SGTC_2892 9047358 58.44 µM -0.984322174271347 0.183805089238429 no 2776 0.162478565062594 933 6466771 SGTC_2522 biochanin a 4.94 µM -0.984661790714538 0.183720976297391 no 2777 0.162395113522318 924 5280373 A possible chelator. SGTC_1221 2958-7315 257 µM -0.986355172862952 0.183301933640677 no 2778 0.161979427151836 936 4562705 SGTC_53 0973-0023 39.979 µM -0.98767068786799 0.182976809294162 no 2779 0.161656977273117 931 674768 SGTC_1131 3454-3128 32.3 µM -0.988285821901114 0.182824904890692 no 2780 0.16150634356219 902 710982 SGTC_1049 3226-0134 66 µM -0.989368001336276 0.182557856980896 no 2781 0.161241562205228 923 5702385 SGTC_950 1165-0508 94.1 µM -0.990207145115088 0.182350950423829 no 2782 0.161036440434325 933 6148369 SGTC_1716 st033144 30.6155 µM -0.992918861650752 0.181683328443141 no 2783 0.160374748568461 926 674617 SGTC_2731 amoxapine 43.43 µM -0.993384893335511 0.181568746090631 no 2784 0.160261210320607 970 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1975 st070967 30.8 µM -0.994320395404537 0.181338872469434 no 2785 0.160033454684126 923 261391 SGTC_1323 1348-1351 11.2 µM -0.994361725577774 0.181328720933605 no 2786 0.160023397399458 912 6989654 SGTC_1011 4112-3381 17.4 µM -0.994605527480633 0.181268845441005 no 2787 0.159964079052695 917 2877139 SGTC_1617 st002906 78 µM -0.995220884329366 0.181117774562622 no 2788 0.159814423301525 945 5150859 SGTC_415 dibenzyl ketone 100 µM -0.997714090260931 0.180506496869492 no 2789 0.15920900936155 939 7593 SGTC_3131 9127911 49.47 µM -0.998293301072288 0.180364672932016 no 2790 0.159068577516092 921 45595681 SGTC_1386 3228-0095 33.8 µM -1.00034381255503 0.179863152525234 no 2791 0.158572075659743 938 870181 SGTC_826 1683-5028 118 µM -1.00300477720782 0.179213632854612 no 2792 0.157929278150675 933 722377 SGTC_1842 st055362 61.2 µM -1.00492988158957 0.178744651547828 no 2793 0.157465307295417 916 676032 SGTC_1058 3448-5425 97.3 µM -1.00523401492499 0.178670631316406 no 2794 0.157392089916176 912 7279705 SGTC_2586 curcumin 80 µM -1.00642341363428 0.178381339814721 no 2795 0.157105967731612 949 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_658 3253-0951 102 µM -1.00653535056825 0.178354129156052 no 2796 0.157079057765198 943 1184878 SGTC_500 h-89 112 µM -1.00731798888806 0.178163951314999 no 2797 0.156890993924875 941 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_985 1493-0307 8.71 µM -1.00903385123175 0.177747451450758 no 2798 0.156479199941703 951 3278274 SGTC_2437 5741531 144.16 µM -1.01070381231027 0.177342683775372 no 2799 0.156079105933791 900 2262990 SGTC_1876 myriocin 605 nM -1.01073603076719 0.177334880344251 no 2800 0.156071393578922 926 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2163 5671233 125 µM -1.01148633636557 0.177153214832802 no 2801 0.155891858764272 908 701023 SGTC_3222 9128301 49.47 µM -1.01246169506451 0.176917234807627 no 2802 0.155658676344855 915 4911358 SGTC_159 3970-0959 50 µM -1.01280987800141 0.176833042943643 no 2803 0.155575490776856 901 6615653 SGTC_988 1497-1057 103 µM -1.01301089644499 0.176784447506805 no 2804 0.155527478132344 933 3533044 SGTC_139 0099-0334 718.624 µM -1.0157263468087 0.176128825244158 no 2805 0.154879859026538 946 97690 SGTC_3215 9129942 49.47 µM -1.01585641870007 0.176097459174566 no 2806 0.154848882407099 952 17682944 SGTC_1392 3455-1037 33.9 µM -1.02763795751397 0.173271084432007 no 2807 0.152060081107156 901 981132 SGTC_709 3807-1509 243 µM -1.02794552392831 0.173197688654753 no 2808 0.151987726829097 957 1886677 YPL242C IQG1 SGTC_2674 ligustilide 100 µM -1.02986337266208 0.17274047164363 no 2809 0.151537073361509 933 5319022 A signalling regulator. SGTC_1187 1391-0724 117 µM -1.03039343096082 0.172614241055967 no 2810 0.151412677836941 947 6997986 SGTC_1857 st056007 79.3 µM -1.03421331610299 0.171706295376238 no 2811 0.150518225145875 924 619834 SGTC_1860 st056228 74.6 µM -1.03517059652846 0.171479239013914 no 2812 0.150294623942886 955 688679 SGTC_1954 st077032 68.9 µM -1.03727166564927 0.170981561679853 no 2813 0.149804633462363 961 698907 SGTC_3020 9089140 49.47 µM -1.03744731387901 0.170939998020451 no 2814 0.14976371884419 954 17217859 SGTC_930 2810-3379 265 µM -1.03784859540114 0.170845066986085 no 2815 0.149670274308452 973 1015764 SGTC_2680 butyl paraben 22.24 µM -1.03819965024905 0.170762045730545 no 2816 0.14958855772995 964 7184 An antifungal and steroid mimetic. SGTC_1622 st003707 19.4 µM -1.03936533080904 0.170486558207612 no 2817 0.149317430740452 920 10140899 SGTC_2102 5377816 72.7585 µM -1.04135610229725 0.170016733835471 no 2818 0.148855153963863 936 1379702 SGTC_130 0136-0219 337.655 µM -1.04283412123455 0.169668456980575 no 2819 0.148512562634289 950 234244 SGTC_714 4296-0578 26.1 µM -1.04297053667707 0.169636335455025 no 2820 0.148480969374912 933 1589775 SGTC_2889 9059656 51.95 µM -1.04570472773709 0.168993342638787 no 2821 0.147848689682325 948 3949838 SGTC_2848 9016370 25.97 µM -1.0458874404918 0.168950430414146 no 2822 0.147806501842849 899 7894410 SGTC_1840 st055363 71 µM -1.04719973380416 0.168642428701578 no 2823 0.14750373402335 964 676033 SGTC_3223 9129970 49.47 µM -1.0480915310263 0.168433325597782 no 2824 0.147298218912824 952 17248386 SGTC_2871 9038510 12.99 µM -1.04909839250648 0.16819744340316 no 2825 0.147066417946331 934 4945164 SGTC_1054 3429-0080 167 µM -1.0494689155662 0.168110692736149 no 2826 0.146981177243176 960 1162877 SGTC_420 mitomycin C 81.9 mM -1.05122539753487 0.167699838950198 no 2827 0.146577540585301 918 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_758 0868-0029 16 µM -1.05156353653863 0.167620820087315 no 2828 0.146499922274033 914 762687 SGTC_2377 9073351 62.6 µM -1.05369458631536 0.167123372310558 no 2829 0.146011384152209 968 7337946 YHR072W ERG7 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.05435025487582 0.166970512245623 no 2830 0.145861294131028 929 6312947 SGTC_544 k015-0020 52.4 µM -1.05980058902525 0.165703333830576 no 2831 0.144617664399075 942 3008304 SGTC_3333 9141820 12.094 µM -1.06107244207328 0.165408530810861 no 2832 0.144328490312518 923 1939433 SGTC_2612 dictamnine 15.46 µM -1.06326676722447 0.164900706087281 no 2833 0.14383049573521 915 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2770 toltrazuril 17.5 µM -1.06778630773632 0.163857950203423 no 2834 0.142808457898867 904 68591 Kills coccidiodes. SGTC_2719 novobiocin 32.65 µM -1.06909550748379 0.163556690546614 no 2835 0.142513317892941 965 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_12 0849-0099 9.267 µM -1.06949230850262 0.163465453823888 no 2836 0.142423946407196 933 6071388 SGTC_1652 st011932 78 µM -1.0698908833054 0.16337384253711 no 2837 0.142334213585792 942 1551076 SGTC_1359 1582-0056 520 nM -1.07282470407926 0.162700538648355 no 2838 0.141674887237309 973 3661189 SGTC_732 3970-1727 52.7 µM -1.07647619547722 0.16186505619261 no 2839 0.140857170717668 956 1275699 SGTC_2959 9079155 11 µM -1.07980759326602 0.161105255867514 no 2840 0.14011393457238 937 16189457 SGTC_719 2810-4230 27.3 µM -1.08051148916748 0.160945014842017 no 2841 0.139957236690698 953 721079 SGTC_1172 0370-0043 85 µM -1.08074323177696 0.160892281696804 no 2842 0.139905673346568 965 376585 SGTC_54 0159-0055 9 µM -1.08183432316773 0.160644154893149 no 2843 0.139663076131904 942 3319099 SGTC_440 fluspirilene 35.1 µM -1.08256464260413 0.160478211507653 no 2844 0.139500854153762 968 3396 An atypical antipsychotic. SGTC_2239 6685329 187.64 µM -1.08351955734611 0.160261404524967 no 2845 0.139288937418506 925 805680 SGTC_315 k915-0449 187 µM -1.08512412952077 0.159897528510528 no 2846 0.138933340798781 934 20970215 YNL149C PGA2 SGTC_1862 st057513 3.81 µM -1.08589501004594 0.159722904807464 no 2847 0.138762722420111 955 5393163 SGTC_1704 st028805 70.8 µM -1.08593613405963 0.159713592697863 no 2848 0.138753624485904 958 2876101 SGTC_3254 9136651 49.47 µM -1.08644262058738 0.159598933167353 no 2849 0.138641606940812 963 16454030 SGTC_724 3910-0327 137 µM -1.08761923441717 0.159332776743331 no 2850 0.138381617942746 959 2885483 SGTC_1444 4112-3581 28 µM -1.089790544188 0.158842378205152 no 2851 0.137902710101494 948 2877249 SGTC_656 4090-1979 187 µM -1.09381793950367 0.157935397745755 no 2852 0.137017417275022 946 22330961 SGTC_3347 9188721 44.724 µM -1.09779897750945 0.157042205595197 no 2853 0.13614613903021 967 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_943 3253-1379 105 µM -1.09800088191471 0.156996994695796 no 2854 0.136102052086244 943 668464 SGTC_1155 4088-0394 48.2 µM -1.10133482403951 0.156251688746209 no 2855 0.135375480092819 940 2326248 SGTC_1550 gossypolone 36.6 µM -1.10358763269634 0.155749392987651 no 2856 0.134886029197482 955 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_752 1896-0090 130 µM -1.10534787089294 0.15535766464248 no 2857 0.134504441230637 955 772567 SGTC_1103 duloxetine 36.1 µM -1.10686795574461 0.155019904317195 no 2858 0.134175511031983 975 60835 A selective serotonin reuptake inhibitor. SGTC_3079 9117512 49.47 µM -1.10838747105044 0.154682755537224 no 2859 0.133847256736824 1010 7185044 SGTC_1795 st049545 62.3 µM -1.11005704648162 0.154312870613699 no 2860 0.133487222501828 904 5291882 SGTC_458 nppb 133 µM -1.11066572530484 0.154178166890577 no 2861 0.133356130286223 975 4549 A chloride channel blocker. SGTC_1040 k898-0338 155 µM -1.11119392400874 0.154061336876087 no 2862 0.133242443011136 958 20969351 SGTC_1516 st013856 110 µM -1.11131798870044 0.154033904033284 no 2863 0.133215749521456 964 5281404 A mutagen and neurotoxin. SGTC_873 0591-4978 488 µM -1.11439270074597 0.153355064761238 no 2864 0.132555376682053 958 3305145 SGTC_1350 1495-0454 146 µM -1.11461844854153 0.153305302063477 no 2865 0.132506980614735 954 1069057 SGTC_2651 TUB2.036 5 µM -1.11571728711835 0.153063232461353 no 2866 0.132271584225922 927 15992207 YFL037W TUB2 SGTC_1596 piperlongumine 63 µM -1.11598909647851 0.153003393090093 no 2867 0.132213400933978 946 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3032 9089427 49.47 µM -1.11723434621398 0.152729447185216 no 2868 0.131947069375205 906 17173707 SGTC_664 1222-0054 14.9 µM -1.11758799269691 0.152651706878583 no 2869 0.131871499676985 950 6813991 SGTC_2304 7443016 91.4 µM -1.1217623814505 0.151736056131737 no 2870 0.130981742483724 955 939854 SGTC_1118 chelidonine 707.474 nM -1.1217951561015 0.151728881494602 no 2871 0.130974773126188 956 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2876 9059903 25.97 µM -1.12286192963214 0.151495479201439 no 2872 0.130748069221791 950 6916095 SGTC_104 0074-0074 590.992 µM -1.1232017946623 0.151421169370834 no 2873 0.130675900282108 954 3943124 SGTC_2383 9036125 200 µM -1.12376576840095 0.151297912753635 no 2874 0.130556203556844 965 79580 SGTC_3319 9138450 16.7555 µM -1.12626785966223 0.150751884968476 no 2875 0.130026078844137 929 2029690 SGTC_2138 5575593 77.673 µM -1.12664380161122 0.150669957216978 no 2876 0.12994655595931 957 762213 SGTC_1146 3579-1023 7 µM -1.12795610012838 0.150384204888002 no 2877 0.129669229776537 977 X1146 SGTC_940 3232-1287 54.8 µM -1.12828062459825 0.150313595576375 no 2878 0.129600711748786 963 1585493 YIL048W NEO1 SGTC_2618 avocadyne 43.43 µM -1.13076787954492 0.149773157793569 no 2879 0.129076401299077 960 3015189 SGTC_2499 avocadenofuran 51.48 µM -1.13188484288574 0.149530883099183 no 2880 0.128841425907313 962 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1460 k062-0059 9.15 µM -1.13372275163142 0.149132801449411 no 2881 0.128455431477781 928 1373085 SGTC_2480 5767542 37.17 µM -1.13440995135111 0.148984139467866 no 2882 0.128311313365087 943 2867358 SGTC_1760 st045453 10.4495 µM -1.13464334213892 0.148933672545938 no 2883 0.128262392677754 966 3323419 YIL048W NEO1 SGTC_384 k007-0144 5.16 µM -1.13636028562181 0.148562762845172 no 2884 0.127902904870107 970 6824886 SGTC_2388 9080168 200 µM -1.13802492693229 0.148203742103398 no 2885 0.127555036925294 957 15943073 SGTC_2844 9010103 25.97 µM -1.14189797563541 0.147370672313823 no 2886 0.126748215103332 972 2480525 SGTC_809 3998-0021 90 µM -1.14207349430069 0.147332993765114 no 2887 0.126711735942922 968 715485 SGTC_1609 st001574 46.4 µM -1.14233533389503 0.147276796724368 no 2888 0.126657329744618 957 3960012 SGTC_2134 5324836 1.464 µM -1.14384959238235 0.146952082448275 no 2889 0.126343009467382 983 699272 SGTC_681 1642-0006 26.6 µM -1.14593587366767 0.146505491891697 no 2890 0.125910843236078 991 4446530 SGTC_3042 9091578 49.47 µM -1.14649540820095 0.146385872702479 no 2891 0.125795113041792 948 25236497 SGTC_2389 9091542 195.52 µM -1.14993860710961 0.145651217527085 no 2892 0.125084579106235 950 3626624 YOL127W RPL25 SGTC_23 0213-0011 39.996 µM -1.1522963587655 0.145149590134013 no 2893 0.124599656371672 977 627608 SGTC_2245 6637752 200 µM -1.15643762908457 0.144271324718095 no 2894 0.123751098755257 977 681890 SGTC_1087 pterostilbene 9.05 µM -1.15855658901313 0.143823331685432 no 2895 0.123318486259137 979 5281727 Similar to reservatol, lowers cholesterol. SGTC_400 oxethazaine 37.5 µM -1.15999144010633 0.143520507240733 no 2896 0.123026145609433 962 4621 A local anesthetic. SGTC_1182 1222-0449 220 µM -1.16011633909545 0.143494167764048 no 2897 0.123000721338223 959 658318 SGTC_1363 1636-0063 10.4 µM -1.16208754544588 0.143078899651395 no 2898 0.122599952956824 960 6072185 SGTC_1476 4112-3294 3.34 µM -1.16218550636748 0.143058283717397 no 2899 0.122580060323979 932 704369 SGTC_1660 st012960 28.1 µM -1.1626529507532 0.142959937407423 no 2900 0.12248516896769 961 24207266 SGTC_2083 5306046 65.942 µM -1.16279883442586 0.142929254083838 no 2901 0.122455565092895 954 539837 SGTC_2687 chenodiol 100 µM -1.16521402140843 0.142421920980833 no 2902 0.121966185692034 948 5702181 A cholesterol synthesis inhibitor. SGTC_693 4161-2696 114 µM -1.16678315115073 0.142092963851258 no 2903 0.12164897646052 986 805759 SGTC_2709 st078560 56 µM -1.167467355199 0.141949686374291 no 2904 0.121510842079774 974 17250903 SGTC_1268 0828-0275 2.46 µM -1.16783575824525 0.14187258052973 no 2905 0.12143651064338 967 745337 SGTC_2927 9011802 47.9 µM -1.17041885515474 0.141332741381009 no 2906 0.120916225741517 960 43912568 SGTC_2114 5491910 81.25 µM -1.17051989042509 0.141311654441876 no 2907 0.120895907240363 965 2849228 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.17241229458868 0.140917087288147 no 2908 0.120515782879988 970 641818 YHR062C RPP1 SGTC_2528 xanthyletin 44.79 µM -1.17403983888636 0.140578341849818 no 2909 0.120189534367742 987 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3125 9127534 49.47 µM -1.17503253935022 0.140371999868011 no 2910 0.119990848937102 956 1639235 SGTC_956 1185-0240 191 µM -1.17776735674414 0.139804606910228 no 2911 0.119444682852474 962 1416193 SGTC_2800 7887935 81.82 µM -1.17932966345308 0.139481175547392 no 2912 0.119133465397895 999 2961002 SGTC_996 3970-0799 1.8 µM -1.18014812400626 0.13931193977467 no 2913 0.118970653627506 970 6615648 YGL040C HEM2 SGTC_899 1083-0020 478 µM -1.18030867756129 0.13927875798766 no 2914 0.11893873405144 979 767123 SGTC_1222 0366-0074 1.18 µM -1.18040900051774 0.139258026857621 no 2915 0.118918791962523 975 286520 SGTC_2588 indole-3-carbinol 100 µM -1.18119593067607 0.139095485348692 no 2916 0.118762448738275 969 3712 Induces cell cycle arrest. SGTC_1450 4112-4260 37.6 µM -1.18372284593637 0.138574420865078 no 2917 0.11826139615944 960 1633175 SGTC_677 0929-0063 136 µM -1.18687783778309 0.137925712381653 no 2918 0.117637905131449 1001 1539583 SGTC_275 trichlorophene 5.69 µM -1.18804923454684 0.137685385747209 no 2919 0.117407006498384 941 62616 SGTC_68 0986-0284 82.829 µM -1.19300651129983 0.136671503551538 no 2920 0.11643341149141 938 423278 YIL048W NEO1 SGTC_2265 7929201 200 µM -1.19371056314078 0.136527923089205 no 2921 0.116295603525106 964 1265108 SGTC_3303 9125618 40.5795 µM -1.19578477037237 0.136105520482527 no 2922 0.115890280293144 953 22695467 SGTC_1368 1852-0141 284 µM -1.19795698921807 0.135664118100072 no 2923 0.115466880854002 988 2838987 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.20307978363431 0.134627035070234 no 2924 0.114472723890884 980 368090 SGTC_640 3381-0960 37.1 µM -1.20340546999724 0.13456128602354 no 2925 0.114409726084867 969 1745025 SGTC_163 TUB2.036 7.546 µM -1.20365544355735 0.134510836710702 no 2926 0.114361390219441 945 15992207 YJR013W GPI14 SGTC_393 acivicin 6.25 µM -1.20657875210481 0.13392182243306 no 2927 0.113797206841902 942 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1449 4112-4002 201 µM -1.20691540187458 0.133854105227023 no 2928 0.113732362779596 977 2059539 SGTC_3052 9092717 49.47 µM -1.20958937716845 0.133317070123469 no 2929 0.113218248176595 979 25237534 SGTC_1678 st019265 80.2 µM -1.21204328903255 0.132825538115574 no 2930 0.112747905185468 962 5367020 SGTC_2611 pyromycin 23.93 µM -1.21355862383834 0.132522632251272 no 2931 0.112458157608603 970 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2339 9000433 200 µM -1.21384433288729 0.132465574185821 no 2932 0.112403586761149 970 2988954 SGTC_2224 6650123 117.647 µM -1.21559282009294 0.132116758054608 no 2933 0.112070035301089 998 2908370 SGTC_2216 7189485 200 µM -1.21753832093969 0.131729383497807 no 2934 0.111699732750246 966 731273 SGTC_1788 fluconazole 20 µM -1.21758065118366 0.131720963715551 no 2935 0.111691685441376 966 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_517 1365-0151 113 µM -1.21828723099439 0.13158047486924 no 2936 0.111557420355778 977 768657 SGTC_3141 9094609 49.47 µM -1.21831946640173 0.131574067989882 no 2937 0.111551297703403 985 25236309 YDL196W YDL196W SGTC_360 0957-0399 1.01 µM -1.22147349098727 0.13094823756155 no 2938 0.110953398297473 986 6752301 YPR165W RHO1 SGTC_913 3487-1245 167 µM -1.22219440484606 0.130805481088382 no 2939 0.110817059624202 963 4016153 SGTC_1407 3909-7909 12.3 µM -1.22268405565781 0.130708581043969 no 2940 0.110724525716798 946 4411780 SGTC_1675 st018485 24.5 µM -1.22442794528298 0.130363875022323 no 2941 0.110395416322559 990 3323024 SGTC_597 k018-0003 82.8 µM -1.22453143194532 0.130343439110401 no 2942 0.110375908238414 995 6786234 SGTC_1955 wogonin 32.4 µM -1.22879550958525 0.129503321563048 no 2943 0.109574242779096 964 5281703 A flavanone. SGTC_827 3253-0474 693 µM -1.22905955621408 0.129451422171316 no 2944 0.109524738666959 975 5402065 SGTC_2137 5261020 140 µM -1.22968723562485 0.129328107195506 no 2945 0.109407124258883 968 763655 SGTC_2110 5483698 200 µM -1.23038346773059 0.129191419501431 no 2946 0.109276770616385 972 2848765 YHR062C RPP1 SGTC_1293 1000-1278 195 µM -1.23058294354862 0.129152275896144 no 2947 0.109239443873989 980 678847 SGTC_1907 st060210 83.7 µM -1.23185524683443 0.12890280232508 no 2948 0.109001580745198 987 688793 SGTC_2188 6126565 140.678 µM -1.23213157290108 0.128848664442958 no 2949 0.108949969521789 964 874518 SGTC_772 k072-0172 35.3 µM -1.23240179790837 0.128795737137473 no 2950 0.108899514824581 950 5861980 SGTC_690 glyoxal 20.3 µM -1.23253745598215 0.128769172314352 no 2951 0.108874191944626 976 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_45 0kpi-0036 14.9 µM -1.23990048256459 0.12733302966951 no 2952 0.107506102694087 989 2795021 SGTC_1611 st001856 99.4 µM -1.23995395590903 0.127322640720064 no 2953 0.107496212586665 1002 647478 SGTC_92 0063-0024 660.874 µM -1.24030665307925 0.127254132506333 no 2954 0.107430996269718 1012 3594437 SGTC_568 1193-0097 7.48 µM -1.24195415384821 0.126934460167075 no 2955 0.107126738909833 924 3646150 SGTC_260 nsc-65238 3.989 µM -1.24206127151889 0.126913694991233 no 2956 0.107106978155941 987 3246252 SGTC_2540 epiandrosterone 100 µM -1.24455183423845 0.126431556299456 no 2957 0.106648267344364 978 441302 A steroid. SGTC_584 0986-0246 15.4 µM -1.2458867703986 0.126173656980998 no 2958 0.106402983840097 1004 53315 YDR232W HEM1 SGTC_2953 9074162 66.49 µM -1.24662234958168 0.126031705585887 no 2959 0.106268001432182 959 16451992 SGTC_1546 5-methoxyflavanone 78.7 µM -1.24852705263597 0.125664655315239 no 2960 0.105919053879563 984 147795 SGTC_1807 st050092 58.9 µM -1.24909423867288 0.125555498654697 no 2961 0.105815303811277 989 5008496 SGTC_356 1634-0012 32.5 µM -1.24959973027362 0.125458271050499 no 2962 0.105722900856934 981 735457 SGTC_3029 9088683 49.47 µM -1.25137624167269 0.125116989016719 no 2963 0.105398620554932 980 25236615 SGTC_214 4373-3496 70 µM -1.25277389615743 0.124848944514027 no 2964 0.105144002075307 991 3779166 SGTC_259 usnic acid 108.925 µM -1.25383914305997 0.12464491931458 no 2965 0.104950239269142 1017 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2749 bexarotene 57.39 µM -1.25440605866132 0.124536433855416 no 2966 0.104847225756853 976 82146 An retinoic acid receptor inhibitor. SGTC_3109 9122853 49.47 µM -1.25856621642522 0.123742361882494 no 2967 0.104093527985593 1011 1234709 SGTC_2823 7987624 58.44 µM -1.25928696022068 0.123605150658339 no 2968 0.103963350716489 988 2239440 SGTC_2122 5258151 111.688 µM -1.26089417459045 0.12329956186048 no 2969 0.103673488653382 992 2173356 SGTC_667 1498-1044 59 µM -1.26392427053687 0.122724873176366 no 2970 0.103128604758641 1001 6739982 SGTC_639 0833-0042 114 µM -1.26398805589071 0.122712795856214 no 2971 0.103117157016977 993 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3002 9075603 71.4286 µM -1.26773104024348 0.122005546709682 no 2972 0.102447007968388 959 20105405 SGTC_1985 st071382 65.5 µM -1.26784771299881 0.121983547114092 no 2973 0.102426169732388 1011 6123237 SGTC_2152 5568786 200 µM -1.26856909627242 0.121847586306996 no 2974 0.102297396137583 994 5399883 SGTC_2895 9054447 58.44 µM -1.26902537151356 0.121761646017919 no 2975 0.102216007596664 1010 2697450 SGTC_981 1488-1094 54.9 µM -1.27069342155226 0.121447828175567 no 2976 0.101918868408507 979 3449522 SGTC_1275 0867-0008 21.1 µM -1.27091016019227 0.121407093927958 no 2977 0.101880305724401 991 3422836 SGTC_2833 9001315 45.46 µM -1.27189237011656 0.121222616042267 no 2978 0.101705681572521 979 2989378 SGTC_1178 0988-0033 191 µM -1.27264245425878 0.121081868662821 no 2979 0.101572473190115 978 5392207 SGTC_2404 5161160 200 µM -1.27313777611082 0.120988988465953 no 2980 0.101484578041781 973 2831543 SGTC_2996 9066192 71.4286 µM -1.27324550160748 0.120968794975424 no 2981 0.101465469426667 978 6472854 SGTC_965 1291-5240 308 µM -1.27540618812288 0.120564268068229 no 2982 0.101082754769869 996 2834598 SGTC_425 3825-7017 13.1 µM -1.27556604341867 0.120534377612221 no 2983 0.101054482030806 976 3397440 SGTC_1212 0520-0165 585 µM -1.27651342441623 0.120357339192692 no 2984 0.100887042190927 1010 5403258 SGTC_2394 5221648 200 µM -1.27839440557601 0.120006380635537 no 2985 0.100555197812062 992 788586 SGTC_3194 9111903 49.47 µM -1.27844756529545 0.119996472443116 no 2986 0.100545830910969 998 17087251 SGTC_1378 2093-0007 380 nM -1.28070839006197 0.119575621465431 no 2987 0.100148055851351 1000 3618014 SGTC_2438 5259590 200 µM -1.28162026996507 0.119406170651431 no 2988 0.0999879430196271 986 1201127 SGTC_80 0159-0065 512.242 µM -1.28268080106282 0.119209309813287 no 2989 0.0998019644227835 982 1548079 SGTC_37 0566-0070 1.56 µM -1.28303727015827 0.119143191791267 no 2990 0.0997395094810235 978 1626686 SGTC_187 1488-2104 32.728 µM -1.28389046681228 0.118985045698246 no 2991 0.0995901416691068 994 2852859 SGTC_618 k072-0232 33.2 µM -1.28581912566978 0.118628101413634 no 2992 0.099253096891817 958 5872756 YGL099W LSG1 SGTC_1965 Pectolinarigenin 58.4 µM -1.28626894650144 0.118544960272073 no 2993 0.0991746080719518 1003 5320438 An anti-inflammatory. SGTC_2107 5363541 170.161 µM -1.28828383589262 0.11817305023251 no 2994 0.098823588878406 982 244052 SGTC_762 1165-0429 115 µM -1.28839115586062 0.118153264189729 no 2995 0.0988049179171517 974 5967793 SGTC_454 lyso-paf C-16 6.67 µM -1.28903639804745 0.118034353518693 no 2996 0.0986927165016839 986 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2023 5144124 124 µM -1.28950158652311 0.117948677193295 no 2997 0.0986118825676529 977 2830192 SGTC_3328 9140624 29.0385 µM -1.29440369698081 0.117048502382627 no 2998 0.0977630071634891 1003 4904392 SGTC_2381 9035592 200 µM -1.29537775079107 0.116870218108866 no 2999 0.0975949747246753 1006 4749657 SGTC_3107 9121808 49.47 µM -1.29564759474757 0.116820861747368 no 3000 0.097548461867199 929 662681 SGTC_806 3966-4455 5.86 µM -1.29768035335959 0.116449530734624 no 3001 0.0971985987707324 984 714982 SGTC_1422 4031-0024 15.5 µM -1.29910708357052 0.116189405558098 no 3002 0.0969535912418578 1003 782427 SGTC_838 0109-0203 71.4 µM -1.29997941805078 0.116030562547244 no 3003 0.0968040117324565 983 759422 SGTC_1180 1193-0155 285 µM -1.30023597592653 0.115983875382885 no 3004 0.0967600519257538 1012 2921347 SGTC_1163 k060-0048 49.9 µM -1.30163576297126 0.115729383770609 no 3005 0.0965204641493537 996 6809982 SGTC_786 4544-0069 423 µM -1.3038652726684 0.11532486182205 no 3006 0.0961397613072327 970 748821 YLR208W SEC13 SGTC_527 4476-4215 268 µM -1.30397391136697 0.115305176141748 no 3007 0.0961212388111039 976 4418754 SGTC_903 1134-0042 114 µM -1.30465674857768 0.115181498536157 no 3008 0.0960048776598952 984 701009 SGTC_2217 6934799 96.0675 µM -1.30636314696092 0.114872842749034 no 3009 0.0957145460767174 991 675606 SGTC_456 gingerol 170 µM -1.3071338087933 0.114733637365766 no 3010 0.0955836353833972 999 442793 A herb. SGTC_2182 6325192 200 µM -1.31209860023282 0.113839719287002 no 3011 0.0947434341143663 967 736248 SGTC_236 1509-0011 5.31 µM -1.31773452139959 0.112830991491671 no 3012 0.0937962670081447 1001 3107280 SGTC_776 4476-4378 112 µM -1.32116388191666 0.112220329634599 no 3013 0.0932233632068323 1017 2892008 SGTC_1123 mangostin 811.285 nM -1.32153287987041 0.11215476366316 no 3014 0.0931618733766773 950 5281650 An antioxidant. SGTC_2405 ticlatone 3.52 µM -1.32356448747243 0.11179426470018 no 3015 0.0928238629422487 994 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1812 st052057 4.327 µM -1.32850330451021 0.110921353700758 no 3016 0.0920059463169423 1002 3645418 SGTC_508 roscovitine 141 µM -1.33021687821619 0.110619632088199 no 3017 0.0917234123473606 1020 160355 A CDKinase inhibitor. SGTC_720 r052-1644 49.9 µM -1.33162945170147 0.110371352491857 no 3018 0.0914909910220375 999 1422863 YOR257W CDC31 SGTC_631 k072-0230 41.5 µM -1.33471058195664 0.109831187534906 no 3019 0.0909855444184439 1002 5773147 SGTC_1777 st045864 34.765 µM -1.3358023569737 0.109640240226016 no 3020 0.0908069411992648 1021 4691462 SGTC_3135 9127742 49.47 µM -1.33831198696706 0.109202219373505 no 3021 0.090397377952052 986 3643468 SGTC_700 3453-2283 142 µM -1.33994244691848 0.108918320006989 no 3022 0.090132028369556 992 565664 SGTC_3158 9100007 49.47 µM -1.34503778453204 0.108034529250845 no 3023 0.0893065164632279 1006 19297233 SGTC_2054 5233173 129 µM -1.34551520864189 0.107951984954436 no 3024 0.0892294566231896 869 6889 SGTC_1659 st012954 42.1 µM -1.34821048213433 0.10748683719546 no 3025 0.0887953470779357 1000 24207262 SGTC_1865 st057639 52.2 µM -1.35051117573659 0.107090929848616 no 3026 0.0884260356570525 1002 688818 SGTC_2450 5739737 12.93 µM -1.35344955877774 0.106586818586945 no 3027 0.0879560270389494 992 2262825 SGTC_1526 st051518 75 µM -1.35680470973015 0.106013303547104 no 3028 0.0874216353201998 992 673993 SGTC_2301 7769476 200 µM -1.35724810066599 0.105937679337866 no 3029 0.0873511959039726 990 977820 SGTC_1262 0737-0114 49.6 µM -1.35810360531222 0.105791875717897 no 3030 0.0872154056892576 1012 765919 SGTC_1853 st056710 91.2 µM -1.35857263788868 0.105712000107538 no 3031 0.0871410252887055 1004 269167 SGTC_1909 st060837 51.5 µM -1.35879646469487 0.105673898078133 no 3032 0.087105546955435 977 678937 SGTC_359 0081-0058 15.9 µM -1.35904290163576 0.105631958611783 no 3033 0.0870664972138333 1002 3494159 SGTC_3309 9129340 25.759 µM -1.36141249757309 0.105229306927482 no 3034 0.0866916844153282 999 17158987 SGTC_2166 5933061 31.504 µM -1.36299152164768 0.104961609847651 no 3035 0.086442591331047 1008 2877375 SGTC_886 0866-0150 153 µM -1.36808794673603 0.104100960408462 no 3036 0.0856422745467791 1008 271463 SGTC_1910 st062352 60.4 µM -1.36866171587721 0.104004387565431 no 3037 0.0855525213395717 995 2245730 SGTC_3015 9080845 49.47 µM -1.369015541646 0.103944866457792 no 3038 0.0854972084210646 1010 5296973 SGTC_118 0083-0097 135.343 µM -1.36917635533955 0.103917822301043 no 3039 0.0854720775724078 1029 5207356 SGTC_2824 7998404 51.95 µM -1.36931925376931 0.10389379524959 no 3040 0.0854497510394724 1000 837851 SGTC_573 3702-0553 84.7 µM -1.37073275276033 0.103656345461751 no 3041 0.0852291403905246 992 1222756 SGTC_2318 6029776 164 µM -1.37686511887711 0.102630745814289 no 3042 0.0842769766243747 1002 818325 SGTC_148 3253-0744 288.01 µM -1.38099274075809 0.101944592737062 no 3043 0.0836405963410931 980 6893655 SGTC_2673 kobusone 100 µM -1.3823250012491 0.101723839383624 no 3044 0.083435966373512 1035 6710676 An epoxy ketone and protein crosslinker. SGTC_2872 9044037 25.97 µM -1.383840600978 0.101473130414153 no 3045 0.0832036339892631 1023 6465195 SGTC_2261 9010538 184.68 µM -1.38438868863075 0.101382577205249 no 3046 0.0831197352968986 1012 6457250 SGTC_1292 0kpi-0043 232 µM -1.38496544159629 0.101287351589645 no 3047 0.0830315173668365 1006 3333905 SGTC_1352 1496-0991 99 µM -1.38885636928468 0.100646636799651 no 3048 0.0824382150916662 1021 3000039 SGTC_741 4582-0002 126 µM -1.38889046574835 0.100641035269171 no 3049 0.0824330300884805 995 2912688 SGTC_3065 9113888 49.47 µM -1.38999759581274 0.100459274186771 no 3050 0.0822648037079542 1012 16648368 SGTC_1970 st070122 35.8 µM -1.39087029757791 0.100316168850123 no 3051 0.0821323806088043 1013 102928 SGTC_2789 5281112 71.43 µM -1.39428482331711 0.0997576859228883 no 3052 0.0816158060258952 992 765948 SGTC_317 4495-0002 170 µM -1.3956564143805 0.0995339878699863 no 3053 0.0814089926683177 997 15991618 SGTC_2088 5278280 127.392 µM -1.39693238053491 0.0993262150092218 no 3054 0.0812169530976864 1003 791502 SGTC_1116 jasmonic acid  1.58368 µM -1.3969453198349 0.0993241096543649 no 3055 0.0812150074175864 1006 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_823 0417-1665 178 µM -1.3981020447791 0.0991360306208867 no 3056 0.0810412129699145 1020 3429856 SGTC_303 1348-1668 34.2 µM -1.39810701084919 0.0991352237188627 no 3057 0.0810404674383971 1013 5380509 SGTC_1508 1080-0625 72.9 µM -1.40024452483098 0.0987883598236372 no 3058 0.0807200534169874 973 767111 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.40076568125826 0.0987039242807231 no 3059 0.080642077155003 1009 688761 SGTC_3195 9113082 49.47 µM -1.40228322272187 0.0984583595308764 no 3060 0.0804153441783553 1027 17018038 SGTC_1666 st014829 29 µM -1.40444477921002 0.0981093546955779 no 3061 0.0800932222177565 1027 3858230 SGTC_987 1497-1013 404 µM -1.40548313330371 0.0979420247201225 no 3062 0.079938830686358 1014 1676435 SGTC_1548 st061468 90.8 µM -1.41240693646764 0.0968316034902171 no 3063 0.0789150876155732 1016 390799 SGTC_626 0214-0009 33 µM -1.41301969061496 0.0967337786716361 no 3064 0.0788249672817285 1009 3437874 SGTC_220 paclitaxel 373.376 µM -1.41430669622798 0.0965285474818353 no 3065 0.0786359358526999 1001 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2338 7999974 200 µM -1.41745554887312 0.0960277676633455 no 3066 0.0781748908623822 998 315925 SGTC_3173 9105693 49.47 µM -1.42010591706888 0.0956077474576176 no 3067 0.0777884239599591 1008 17096658 SGTC_3355 9151058 44.0485 µM -1.42489538474065 0.0948521625029788 no 3068 0.0770937219818479 1025 17015728 SGTC_1423 4048-0112 5.59 µM -1.42580893853094 0.0947085415675956 no 3069 0.0769617500360515 1004 X1423 SGTC_2457 5731572 11.68 µM -1.42851959884699 0.0942833386555044 no 3070 0.0765711787893588 1000 2865357 SGTC_2694 st077685 81.9 µM -1.43124266860515 0.093857608497199 no 3071 0.0761803393355069 1006 2838096 SGTC_2729 fluphenazine 10.66 µM -1.43156772539838 0.0938068834186079 no 3072 0.0761337858923489 999 3372 An atypical antipsychotic. SGTC_2722 naftopidil 47.16 µM -1.43282553210925 0.0936107934603974 no 3073 0.0759538514236377 1010 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1989 st071868 50.2 µM -1.44215674984068 0.0921655158975263 no 3074 0.0746290792906174 1004 16414057 SGTC_2367 9070478 135.38 µM -1.44232903718649 0.0921389871443818 no 3075 0.0746047861778677 1000 572802 SGTC_1071 trifluoperazine 6.31 µM -1.44321822262149 0.0920021605129005 no 3076 0.0744795038979167 1041 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_543 3844-1095 191 µM -1.44407724688063 0.0918701179873174 no 3077 0.0743586237826137 1009 4230703 SGTC_3058 9093861 49.47 µM -1.44642602187671 0.0915097992104625 no 3078 0.0740288737908276 993 17217477 SGTC_2038 4100038 30.985 µM -1.44827282871527 0.0912272222455871 no 3079 0.0737703817673605 980 3596803 SGTC_1889 st059080 5.18 µM -1.45083146346813 0.0908367994859471 no 3080 0.0734133980573162 1020 176925 Isolated from Daphnopsis sellowiana. SGTC_1344 1488-0097 29.1 µM -1.45115719070508 0.0907871857761199 no 3081 0.0733680471792779 1023 747966 SGTC_2319 6033012 152.6 µM -1.45281248999712 0.0905353667048291 no 3082 0.0731379115753253 1013 847246 SGTC_2855 9016525 58.44 µM -1.45288358896248 0.0905245621145681 no 3083 0.0731280391007495 1003 43811474 SGTC_2449 5812982 45.77 µM -1.45718820943875 0.0898721904042129 no 3084 0.07253221716943 1021 776185 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.46111066986368 0.0892807841625531 no 3085 0.0719925362676134 1021 6710655 SGTC_431 k089-0097 107 µM -1.46489849620608 0.0887124300986633 no 3086 0.0714743065819191 968 5499420 SGTC_3342 9147791 14.508 µM -1.46704535101174 0.0883914985035247 no 3087 0.0711818594174573 1006 1838168 SGTC_753 1322-0200 289 µM -1.4683101640935 0.0882028280456337 no 3088 0.0710099956398258 1027 5403907 SGTC_519 k048-0011 62.8 µM -1.4701926089152 0.0879225823814049 no 3089 0.0707547979580281 1001 6836379 SGTC_2030 5175110 200 µM -1.47117329039682 0.0877768484877107 no 3090 0.0706221292553136 1031 2831986 SGTC_2945 9067681 61.76 µM -1.47232614441851 0.0876057594506309 no 3091 0.0704664132575532 1030 16456930 SGTC_2943 9068529 45.32 µM -1.47306612669583 0.0874960737422045 no 3092 0.0703666030182816 1014 3270634 SGTC_1161 k007-0610 110 µM -1.47424927834313 0.0873209111481648 no 3093 0.0702072431340216 996 5843850 SGTC_3161 9100388 49.47 µM -1.47770499319581 0.0868108003964112 no 3094 0.0697433786639683 1042 25236368 SGTC_2093 5331342 194.4 µM -1.47807894307726 0.0867557340705408 no 3095 0.0696933247391527 1019 33839 SGTC_1257 0669-0121 16 µM -1.48442168197134 0.0858257004210547 no 3096 0.068848543098437 1004 4307855 SGTC_2769 toremifene 3.73 µM -1.48470308206275 0.0857846123784866 no 3097 0.0688112474667357 1017 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_888 0916-0002 6.97 µM -1.48591088262883 0.0856084251309943 no 3098 0.0686513473428239 1021 2802138 YIL048W NEO1 SGTC_1405 3909-7894 12 µM -1.49073380226189 0.0849075849352057 no 3099 0.0680156988644329 975 7104060 SGTC_1253 0550-0034 176 µM -1.49323026274303 0.0845465067117459 no 3100 0.0676884615000217 1014 5969915 SGTC_309 k408-0051 1.48 µM -1.49513827496728 0.0842713168476733 no 3101 0.0674391792975577 999 3640463 SGTC_2481 5478948 45.16 µM -1.50223033748612 0.0832543306126017 no 3102 0.0665188162253795 1016 77792 SGTC_2724 maprotiline 69.64 µM -1.50346619017835 0.0830780600780949 no 3103 0.0663594345906523 994 4011 A tricyclic antidepressant. SGTC_1774 st048371 48.465 µM -1.50596202925655 0.0827229328160164 no 3104 0.0660384607025149 1027 4242727 SGTC_2968 9090663 33.37 µM -1.50779836873732 0.0824623745789578 no 3105 0.0658030698970802 984 25236811 SGTC_2635 hydroquinidine 100 µM -1.51083354546381 0.0820330686323696 no 3106 0.0654154328099504 1020 442912 An experimental heart treatment. SGTC_2723 salbutamol 83.58 µM -1.51099198021331 0.0820107054018525 no 3107 0.0653952470861267 1012 9884233 β2-adrenoceptor agonist SGTC_1815 st051655 58.2 µM -1.51439392840024 0.0815316244167193 no 3108 0.0649629791391225 1011 5984156 SGTC_3274 9138298 49.47 µM -1.5144564989506 0.081522832696231 no 3109 0.06495504944606 1032 17015756 SGTC_1761 st044296 37 µM -1.51633001936071 0.0812599174270393 no 3110 0.0647179622940046 1028 1826700 SGTC_3053 9095903 49.47 µM -1.51854325746134 0.0809501536256315 no 3111 0.0644387515970812 1054 17174018 SGTC_2253 7938677 135.83 µM -1.52652019407315 0.0798410986596725 no 3112 0.0634401825842153 1043 2301972 SGTC_2884 9058502 51.95 µM -1.52699705261466 0.0797751655642972 no 3113 0.0633808721396975 1025 6471554 SGTC_1192 1488-0095 21.4 µM -1.53197367218279 0.0790895264395644 no 3114 0.0627644658853549 1035 915875 SGTC_20 0481-0013 4.944 µM -1.53204454732117 0.0790797941576547 no 3115 0.0627557211204451 1011 182045 SGTC_2568 diosmetin 100 µM -1.53428885262372 0.0787720842561995 no 3116 0.0624793034569202 1026 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_638 3970-0837 4.09 µM -1.53730078290334 0.0783605544859719 no 3117 0.0621098349296085 1018 4118451 YLR208W SEC13 SGTC_2097 5376186 200 µM -1.53782965161616 0.0782884620065766 no 3118 0.062045135763997 1032 742755 SGTC_2424 5537928 59.2 µM -1.53785994224309 0.078284334478011 no 3119 0.0620414317522823 1008 5382802 SGTC_1904 st060225 78 µM -1.54107537277151 0.0778471242570976 no 3120 0.0616492214180415 1005 66595 SGTC_2154 5570129 200 µM -1.54133762665688 0.0778115468327282 no 3121 0.0616173179156675 1050 673366 SGTC_1734 st037168 69.4 µM -1.54155051101777 0.0777826759654327 no 3122 0.061591429756935 1030 708907 SGTC_554 4483-2211 187 µM -1.54676904954502 0.0770774902202241 no 3123 0.0609594729867142 1040 747107 SGTC_1202 1988-0068 29.6 µM -1.55035460441638 0.0765957941176567 no 3124 0.0605282139742515 1021 2850480 SGTC_3092 9117248 49.47 µM -1.55159605462228 0.0764295480158706 no 3125 0.0603794538927704 1055 17141857 SGTC_1225 1216-0074 20.6 µM -1.55374482203214 0.0761424494938362 no 3126 0.0601226484792806 1031 4241466 SGTC_1775 st081588 35.1725 µM -1.55505435773274 0.07596788441678 no 3127 0.0599665619619444 1009 1426443 YGL099W LSG1 SGTC_271 rotenone 740 µM -1.5563773561482 0.075791834329907 no 3128 0.0598091932362558 1042 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_490 phenamil 164 µM -1.55743357187424 0.0756515079554388 no 3129 0.0596837903116078 965 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3097 9117246 49.47 µM -1.55941253045867 0.0753891210736012 no 3130 0.0594493862196798 1022 16423892 SGTC_3175 9106517 49.47 µM -1.55972561423136 0.0753476734339909 no 3131 0.0594123682143043 1042 41468073 SGTC_1981 st071826 47 µM -1.55986255791509 0.0753295495862145 no 3132 0.0593961821208301 1010 11838600 SGTC_2244 6635614 200 µM -1.56014398583422 0.0752923143662631 no 3133 0.0593629295287196 1039 836499 SGTC_1333 1482-0047 286 µM -1.560770635797 0.0752094538463368 no 3134 0.0592889390741564 1030 3811116 SGTC_536 3852-0578 10.6 µM -1.56109786828938 0.0751662122685644 no 3135 0.059250330495076 1039 2869208 SGTC_1413 3910-0535 34.4 µM -1.56249270504747 0.074982106542522 no 3136 0.0590859815316703 1032 2876951 SGTC_2342 7990637 118.86 µM -1.57409899119961 0.0734634964143263 no 3137 0.0577322828827045 1036 2033102 YER133W GLC7 SGTC_1443 4112-3303 14 µM -1.58390947129481 0.0721982956587249 no 3138 0.0566071608698533 1040 704433 SGTC_2305 7443522 69.23 µM -1.58626716834044 0.0718967407186049 no 3139 0.0563393583293543 1016 5415886 SGTC_850 0388-0143 75.9 µM -1.58685543833585 0.0718216503894301 no 3140 0.0562726947263141 1040 67273 SGTC_2675 theaflavin digallate 100 µM -1.58818883585247 0.0716516701837449 no 3141 0.0561218224239568 1045 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3226 9131256 49.47 µM -1.58994120097907 0.0714287499352311 no 3142 0.0559240297262519 1014 17178073 SGTC_1438 4092-1045 4 µM -1.59031829234174 0.0713808494061696 no 3143 0.0558815387100707 1023 1351342 SGTC_2677 mitomycin C 100 µM -1.59118673694446 0.0712706278595873 no 3144 0.0557837784132042 1057 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1238 0333-0287 48.8 µM -1.5925607101113 0.0710965124103094 no 3145 0.0556293867633309 1026 7226 SGTC_2940 9060638 45.86 µM -1.59259467915058 0.0710922118573885 no 3146 0.055625573981315 1016 4027022 SGTC_2576 guaiol 23.12 µM -1.59300547576912 0.0710402199423708 no 3147 0.0555794813230381 1006 227829 SGTC_870 0573-2213 57.6 µM -1.59395816119356 0.0709197570013599 no 3148 0.0554727030861332 1027 3916321 SGTC_1824 st053723 68.6 µM -1.59420835315394 0.0708881473422624 no 3149 0.05544468811025 1026 675225 SGTC_2801 7907800 81.82 µM -1.59456034122559 0.070843694922582 no 3150 0.0554052935382957 1013 6620925 SGTC_2363 9053361 176 µM -1.59830768121018 0.0703717717081162 no 3151 0.0549872593887658 1040 6469797 YMR079W SEC14 SGTC_963 1269-2853 151 µM -1.6043835654622 0.0696117438709489 no 3152 0.0543147656616036 1033 3668223 SGTC_189 3970-0742 2.116 µM -1.60671661968831 0.0693215888961882 no 3153 0.0540582730679404 1022 2891807 SGTC_3003 9075612 71.4286 µM -1.60819968553575 0.0691376293376451 no 3154 0.0538957260179255 1047 6501993 SGTC_854 0422-0053 192 µM -1.60829738783514 0.0691255235594462 no 3155 0.0538850312474266 1040 3596728 SGTC_2317 5986382 200 µM -1.60945206798422 0.068982576907543 no 3156 0.0537587639248353 1051 877883 SGTC_2112 5488546 200 µM -1.61121593486935 0.0687646543897231 no 3157 0.053566332925007 1048 600757 SGTC_1434 4073-0095 163 µM -1.61146488873103 0.0687339393923936 no 3158 0.0535392170298141 1033 24133745 SGTC_1603 st002045 67.8 µM -1.61188266875792 0.0686824190279293 no 3159 0.0534937371358945 1040 5887985 SGTC_3142 9086498 49.47 µM -1.6172987822705 0.0680172000863519 no 3160 0.0529069010159277 991 25236367 SGTC_1298 1079-1278 263 µM -1.61763738333977 0.0679757781561969 no 3161 0.052870383844404 1034 2840950 SGTC_1252 0493-0875 34.8 µM -1.61834515786793 0.0678892572092468 no 3162 0.0527941169311072 1026 3960963 SGTC_3121 9125696 49.47 µM -1.61850465716643 0.0678697711787087 no 3163 0.0527769419901228 1063 1235365 SGTC_1376 2910-0861 41.3 µM -1.61899270299431 0.0678101734445276 no 3164 0.0527244165750396 1042 1112859 SGTC_967 1306-0166 352 µM -1.62015975544191 0.0676678226913912 no 3165 0.0525989819695088 1048 4437607 SGTC_3348 9149464 3.537 µM -1.62555056615961 0.0670132750259061 no 3166 0.0520226492842663 1025 1951442 SGTC_1901 st060216 58.6 µM -1.62626026905529 0.0669274695279077 no 3167 0.0519471499594451 1023 688792 SGTC_2184 6075246 200 µM -1.62791362275606 0.0667279030726662 no 3168 0.0517716012168981 1034 2267320 SGTC_2751 anetholtrithion 17.25 µM -1.63067963384236 0.0663950643862821 no 3169 0.0514789680709146 1040 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2557 derrustone 83.84 µM -1.63610011293216 0.0657465386518251 no 3170 0.0509093182897407 1027 629853 An antioxidant. SGTC_171 k064-0041 9.68 µM -1.6396850308098 0.065320331044237 no 3171 0.0505353364741147 1004 53325 SGTC_609 0986-0026 86.3 µM -1.64105576618273 0.0651579331735578 no 3172 0.0503929198520128 1016 2848610 SGTC_1136 pergolide 1.05886 µM -1.64141462739154 0.0651154688833752 no 3173 0.0503556877741048 1028 47811 A dopamine receptor agonist. SGTC_2031 5180455 200 µM -1.64379232552098 0.0648346565906318 no 3174 0.0501095535773332 1041 29949 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.64472373604394 0.0647249112499167 no 3175 0.0500133978130706 1047 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1735 st034310 56.75 µM -1.64648540473282 0.064517733576091 no 3176 0.0498319312803178 1028 871153 SGTC_2272 7805186 180 µM -1.65622547957929 0.0633815557757199 no 3177 0.04883808258593 1037 2956062 YPR165W RHO1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.66183785568604 0.062733981788899 no 3178 0.048272644848954 1024 5711223 A potent inhibitor of glutathione S-transferases. SGTC_805 3852-0218 479 µM -1.66649765047194 0.0622002472897722 no 3179 0.0478071678885108 1035 6615355 SGTC_2994 9053520 71.4286 µM -1.67194920785081 0.0615803275863212 no 3180 0.047267169122176 1034 4647384 SGTC_1636 st007707 68.9 µM -1.67362408733003 0.0613908419458671 no 3181 0.0471022507591755 1035 403051 SGTC_2440 5628896 157.78 µM -1.67868366376186 0.0608211977685596 no 3182 0.0466068557021483 1040 5522048 SGTC_2772 vinpocetine 57.06 µM -1.68341463678015 0.0602922974011501 no 3183 0.0461474258727967 1048 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2243 6634756 200 µM -1.68380052304909 0.0602493164297689 no 3184 0.0461101130544657 1026 885676 SGTC_117 lucigenin 22.078 µM -1.68389958332097 0.0602382867201816 no 3185 0.0461005384479573 1057 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_450 aminopyrene 156 nM -1.69018649947846 0.0595415077736473 no 3186 0.0454961401901958 1040 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2793 7325131 81.82 µM -1.69203696887374 0.0593376280414731 no 3187 0.0453194625382996 1027 4176441 SGTC_2702 st077768 96.8 µM -1.69235088219092 0.0593030962839094 no 3188 0.0452895457973559 1036 6484119 SGTC_1313 1220-0047 237 µM -1.69509138814231 0.0590022982019135 no 3189 0.0450290428316381 1033 3528706 SGTC_153 4077-0274 519.67 µM -1.69662134478426 0.0588348914626404 no 3190 0.0448841358664196 1034 3121976 SGTC_2036 5160441 105 µM -1.70195189996009 0.0582545362880195 no 3191 0.0443821927188604 1024 134534 YIL048W NEO1 SGTC_1572 epiandrosterone 68.9 µM -1.70409746724428 0.058022214478959 no 3192 0.0441814398668782 1040 441302 A steroid. SGTC_13 0199-0087 65 µM -1.7092928143299 0.057462678923586 no 3193 0.0436983618438261 1057 4589825 SGTC_1961 st076550 68.7 µM -1.71031060584985 0.0573535623052136 no 3194 0.0436042258021124 1047 1579337 SGTC_2903 5923464 63.88 µM -1.72132855692623 0.0561827453900254 no 3195 0.0425956101585962 1058 2876576 SGTC_2755 lomerizine 42.69 µM -1.72240217240903 0.0560696732228367 no 3196 0.0424983452199326 1035 3949 A calcium channel blocker. SGTC_2560 caryophyllene 100 µM -1.72963113151928 0.0553129920491534 no 3197 0.0418481001182211 1055 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_333 3486-0131 40.1 µM -1.73627428565052 0.0546247613948283 no 3198 0.0412576738559234 1035 6744690 SGTC_1448 4255-0083 152 µM -1.75036953418396 0.0531869264250502 no 3199 0.0400272847526518 1063 5399660 SGTC_2153 5569715 200 µM -1.75130839915201 0.0530922302786914 no 3200 0.0399464008631029 1056 2054701 SGTC_2867 9039098 71.43 µM -1.75830534695408 0.0523907058610894 no 3201 0.0393477841997563 1029 6463460 SGTC_1841 st054148 70 µM -1.76118545328194 0.0521040888051552 no 3202 0.0391035096622021 1050 675442 SGTC_1276 0871-0068 94.2 µM -1.7626363117073 0.0519601774854194 no 3203 0.0389809243332746 1048 3414906 SGTC_2240 6690706 185.951 µM -1.76436146550533 0.0517894699085656 no 3204 0.0388355707837635 1044 805876 SGTC_191 3914-0123 66.505 µM -1.76723447479281 0.0515061692488153 no 3205 0.0385944841726356 1063 3144412 SGTC_906 1165-0455 526 µM -1.77519039668735 0.050728082954461 no 3206 0.0379332274300758 1051 3252859 SGTC_821 1114-0266 29.2 µM -1.7782992583014 0.0504265927415043 no 3207 0.0376773590576547 1049 3123235 SGTC_531 3788-1495 174 µM -1.78007372044885 0.0502551505742965 no 3208 0.0375319483639218 1036 2896655 SGTC_872 0588-0139 234 µM -1.7807780624342 0.0501872285135005 no 3209 0.0374743573039385 1055 2047100 SGTC_1047 2043-3044 82 µM -1.78221616274946 0.0500487749218514 no 3210 0.0373569940371418 1055 669592 SGTC_3067 9117431 49.47 µM -1.78845701866423 0.0494514595360793 no 3211 0.0368511520898486 1058 17150885 SGTC_1604 st002052 72.4 µM -1.80934477864354 0.0474935790169013 no 3212 0.035198728200885 1058 6254834 YHR062C RPP1 SGTC_601 0986-0029 62.9 µM -1.81234145484774 0.0472178553114671 no 3213 0.0349667264440137 1029 24747981 SGTC_2178 5812956 200 µM -1.81512554051299 0.0469628431786012 no 3214 0.0347523095125405 1047 5403383 SGTC_2307 7538926 6.34 µM -1.81950756423481 0.0465637041719345 no 3215 0.0344170149230714 1037 96582 SGTC_1819 st053448 58.6 µM -1.82773573034066 0.0458215953168701 no 3216 0.0337946114771475 1072 2857616 SGTC_337 1315-0038 354 µM -1.83563012967578 0.0451185529025732 no 3217 0.0332061889659615 1053 1626437 SGTC_1588 farnesol 29.9 µM -1.83618634258846 0.045069348037582 no 3218 0.0331650509305637 1041 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1871 st057448 67.3 µM -1.83644675001617 0.0450463261804034 no 3219 0.0331458053841552 1059 691747 SGTC_603 3794-0023 45.9 µM -1.86219096969511 0.0428166697877405 no 3220 0.0312880884255575 1064 3802260 SGTC_1786 berberine 21.6 µM -1.86804046799579 0.0423227002299971 no 3221 0.0308782152211904 1008 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2597 laccaic acid a 100 µM -1.87835227611778 0.0414631386512614 no 3222 0.0301664947800815 1063 5491415 A textile dye. SGTC_397 arbidol 50 µM -1.8933505516429 0.0402382333202803 no 3223 0.0291556333389771 1062 131410 A RNA synthesis inhibitor. SGTC_629 3448-6466 76.7 µM -1.89344922952209 0.0402302727265642 no 3224 0.0291490769453838 1064 573744 SGTC_6 0844-0013 19.835 µM -1.90600622931031 0.0392276595860892 no 3225 0.0283246987286799 1078 1584900 SGTC_296 1222-0039 74.9 µM -1.90987042703311 0.0389232470977912 no 3226 0.0280749492970117 1067 5984176 SGTC_265 mycophenolic acid 32.932 µM -1.91085610115929 0.0388459066932023 no 3227 0.0280115379086292 1078 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_852 0418-0143 439 µM -1.91145464824443 0.0387990031197871 no 3228 0.0279730898091226 1004 5369229 SGTC_1520 flindersine 88 µM -1.91638275407595 0.0384145760423723 no 3229 0.0276581971724256 1037 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2478 5763493 32.33 µM -1.91696290557014 0.0383695251079469 no 3230 0.0276213221876308 1040 1365576 YLR208W SEC13 SGTC_2596 sinensetin 100 µM -1.92000418097842 0.0381340629082289 no 3231 0.0274286856486764 1051 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3302 9125395 16.351 µM -1.92281718490545 0.0379173244147623 no 3232 0.027251506554492 1049 17599668 SGTC_3305 9127027 53.8275 µM -1.92454906640419 0.0377843857149667 no 3233 0.0271428983352385 1056 41905295 SGTC_1613 st002381 52.1 µM -1.93311584038869 0.0371323865995321 no 3234 0.0266109645709812 1060 551167 SGTC_323 4013-0906 34.3 µM -1.93482898909238 0.0370031120097009 no 3235 0.0265056422412498 1062 2910086 SGTC_1353 1498-1206 8.11 µM -1.93697448900675 0.0368417312251551 no 3236 0.0263742309429071 952 6756808 SGTC_2689 tacrolimus 100 µM -1.93783612001051 0.0367770830158509 no 3237 0.0263216097469185 1025 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1569 carminic acid 40.6 µM -1.93872977201077 0.0367101303081203 no 3238 0.0262671257182334 1060 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_467 ro 31-8220 72.8 µM -1.9504446096191 0.0358416348922059 no 3239 0.0255615746256582 1049 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_607 4491-0986 66.8 µM -1.95453741066022 0.035542206532361 no 3240 0.0253188475363266 1005 698981 YDR232W HEM1 SGTC_15 0266-0086 27.098 µM -1.95843346278491 0.0352590805602951 no 3241 0.0250895857168511 1080 1712902 YIL048W NEO1 SGTC_195 4234-0266 16.654 µM -1.97175837853845 0.0343047117662803 no 3242 0.0243185978977102 1068 2303354 SGTC_3147 9097027 49.47 µM -1.97941966298461 0.0337656694837509 no 3243 0.0238843882365014 1062 25236841 SGTC_1320 1313-0481 95.3 µM -1.98957610665565 0.0330618322456472 no 3244 0.0233188251798107 1068 6813365 YLR208W SEC13 SGTC_122 0236-0016 402.397 µM -1.99774582135601 0.0325044867754727 no 3245 0.0228721118866407 1043 6808838 SGTC_2593 nobiletin 86.24 µM -2.00667430567298 0.0319042645787439 no 3246 0.0223921768176862 1054 72344 An anti-infammatory. SGTC_150 3970-0969 77.2 µM -2.00715105890287 0.0318724737653976 no 3247 0.02236679047709 1058 6615640 SGTC_2592 piperlongumine 83.33 µM -2.01459839202095 0.0313792590914838 no 3248 0.0219733730529158 1061 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_857 0438-0306 1.35 µM -2.01862856692392 0.0311149950070752 no 3249 0.0217629197828198 1067 4686136 SGTC_2453 5731132 22.18 µM -2.02300936353522 0.0308298313457563 no 3250 0.0215360910732843 1068 1362040 SGTC_350 k064-0020 19.8 µM -2.02606377133726 0.03063229044214 no 3251 0.0213791250260604 1024 2790705 SGTC_1724 st037281 8.293 µM -2.0536722032775 0.0288938670282481 no 3252 0.0200037143196658 1052 574124 YDL195W SEC31 SGTC_93 0109-0045 59.227 µM -2.05531011030313 0.0287933634090955 no 3253 0.0199245307065698 1071 88733 SGTC_1657 st012939 43.4 µM -2.06419899511989 0.0282529885510162 no 3254 0.0194994263807146 1072 24207257 SGTC_792 4534-1957 155 µM -2.06475234745453 0.0282196300318571 no 3255 0.0194732193809535 1068 1717904 SGTC_2881 9058953 51.95 µM -2.0675803170268 0.0280496590970163 no 3256 0.0193397522593497 1044 17122249 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.09341462050338 0.0265360425516755 no 3257 0.018156079201884 1069 676296 Flavone; oxidizing agent. SGTC_3143 9086658 49.47 µM -2.12347369388373 0.0248614059166341 no 3258 0.0168570887986169 1046 25236626 SGTC_1412 3909-8563 178 µM -2.12571574611915 0.0247401314915539 no 3259 0.0167634675153846 1078 23767530 SGTC_1391 3442-0225 151 µM -2.12756891527764 0.024640267039048 no 3260 0.0166864208963542 1069 5227075 SGTC_1950 st077106 7.18 µM -2.12913619078639 0.0245560731511317 no 3261 0.0166214971414958 1051 13831864 SGTC_1685 st024049 53.0905 µM -2.13216584895196 0.0243940045715041 no 3262 0.0164966074334968 1071 1941139 SGTC_266 formosanin C 406 nM -2.13289665430159 0.0243550455745614 no 3263 0.0164666024369043 1049 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2813 7971799 71.43 µM -2.14749539388115 0.0235876705529695 no 3264 0.0158769317495666 1068 2234054 SGTC_2762 leflunomide 42.06 µM -2.15316095519769 0.0232953910961343 no 3265 0.0156530155353975 1078 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2798 7813637 45.45 µM -2.16659366910788 0.0226145751761657 no 3266 0.0151329252788658 1067 956368 SGTC_472 calcifediol 10 µM -2.17878389638867 0.0220113261808787 no 3267 0.01467386290246 1084 5283731 A vitamin D metabolite. SGTC_8 0354-0001 70 µM -2.18463283719961 0.0217267412599486 no 3268 0.0144578891264063 1080 4993152 SGTC_486 niguldipine 82 µM -2.1896251815019 0.0214862994863001 no 3269 0.0142757156094755 1082 1236 A calcium channel blocker. SGTC_305 1682-2595 20.8 µM -2.1917731576457 0.0213835426118303 no 3270 0.0141979451142356 1069 226033 SGTC_2595 hexamethylquercetagetin 100 µM -2.20533661328635 0.0207442318453583 no 3271 0.0137152412104899 1071 386331 SGTC_892 0929-0076 29 µM -2.22943709622271 0.0196481724657197 no 3272 0.0128924181532322 1074 5751038 SGTC_1242 0402-0103 60.1 µM -2.22959801138586 0.0196410227885116 no 3273 0.0128870709990069 1073 432868 SGTC_1627 st003713 25.6 µM -2.2309158855697 0.019582550953906 no 3274 0.0128433506355368 1068 16195070 YER133W GLC7 SGTC_3104 9120930 49.47 µM -2.23109411822206 0.0195746544339403 no 3275 0.0128374476423303 1074 17014836 SGTC_1691 st019933 84.6 µM -2.23493033150261 0.0194053470146988 no 3276 0.0127109614504432 1083 6176082 SGTC_596 1155-0152 116 µM -2.24055076826098 0.0191595423263988 no 3277 0.0125275943765391 1079 280313 SGTC_3146 9095609 49.47 µM -2.2527016948038 0.0186371675837002 no 3278 0.0121389820108519 1071 17173999 SGTC_3013 9080133 71.4286 µM -2.25916256018199 0.0183643827606019 no 3279 0.0119366373987291 1078 17050193 SGTC_3188 9110789 49.47 µM -2.27846531830956 0.0175695730486457 no 3280 0.0113494342840372 1064 849217 SGTC_1713 st033146 12.748 µM -2.2901309368417 0.0171036114365371 no 3281 0.011006863733427 1082 674619 SGTC_377 3970-0964 33.1 µM -2.29634590652395 0.016859706892225 no 3282 0.0108280556237958 1075 16481235 SGTC_1249 0481-0015 10.2 µM -2.2978656174486 0.0168005209383074 no 3283 0.0107847193571175 1065 4227577 SGTC_1809 st050081 57.6 µM -2.31855034097967 0.0160124498362767 no 3284 0.0102097151870121 1072 5036894 SGTC_2997 9067075 71.4286 µM -2.33203909878751 0.0155157874942871 no 3285 0.00984931718875188 1066 27209819 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -2.33610918823592 0.0153685460931645 no 3286 0.00974277577843174 1068 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_993 3909-8757 62.7 µM -2.33689643737893 0.0153402051154928 no 3287 0.00972228482165007 1073 4288324 YLR208W SEC13 SGTC_2683 piperine 63.03 µM -2.33705890365007 0.015334361917976 no 3288 0.00971806074972712 1087 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2569 tetrandrine 100 µM -2.34037578699304 0.0152154853695094 no 3289 0.00963217267655015 1072 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1454 4239-0054 42.6 µM -2.34415771115764 0.0150809085764326 no 3290 0.00953505284665511 1070 1340767 SGTC_1737 st035557 69.7 µM -2.3472185509505 0.0149727411533068 no 3291 0.00945707838022524 1064 5716916 SGTC_919 tnp00227 403.569 nM -2.35925316592474 0.0145538900437771 no 3292 0.00915587922089407 1078 1269246 A methoxyflavone. YNL221C POP1 SGTC_1848 st056003 16.4 µM -2.38307359816738 0.0137545094185341 no 3293 0.00858438073043797 1074 146492 SGTC_1286 0929-0070 131 µM -2.38412619676133 0.0137200770334741 no 3294 0.00855986525216164 1077 1420408 SGTC_1822 st052468 42 µM -2.41911556784897 0.0126170710391123 no 3295 0.00777914817558885 1080 2873678 SGTC_1029 k015-0030 64.7 µM -2.42155236021959 0.0125431960544183 no 3296 0.00772718723617248 1076 2208316 SGTC_2086 5274770 176.623 µM -2.43324219156895 0.0121939859176073 no 3297 0.00748214387430509 1077 689278 SGTC_1951 sophoraflavanone G 9.2 µM -2.43924306755988 0.012018017426521 no 3298 0.00735903236396049 1069 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_88 0180-0332 8.668 µM -2.44334608384543 0.0118989726814593 no 3299 0.00727588761893977 1077 3101745 SGTC_2087 5276107 200 µM -2.45086212768459 0.011683554025848 no 3300 0.00712572645414929 1085 144405 SGTC_476 mead acid 10 µM -2.46571127866168 0.0112678934489392 no 3301 0.00683707526210279 1086 5312531 An omega 9 fatty acid. SGTC_3300 9124615 50.48 µM -2.46863895767777 0.0111874756774044 no 3302 0.00678139910505542 1080 24824903 SGTC_3108 9121785 49.47 µM -2.47281450229349 0.0110736449465998 no 3303 0.00670268518902579 1034 17140271 SGTC_2393 9031399 185.94 µM -2.49179901845308 0.0105687134367919 no 3304 0.00635489668742937 1080 1526623 YDL150W RPC53 SGTC_2314 7727897 200 µM -2.49699376336442 0.0104340927269858 no 3305 0.00626255797617326 1060 900724 SGTC_1699 st031318 29.054 µM -2.53301620381171 0.00954102874797688 no 3306 0.00565428625791372 1082 5340658 SGTC_73 0327-0325 16.231 µM -2.56857811604188 0.00872566847658818 no 3307 0.00510583468879114 1026 53298 SGTC_2297 7971671 152.32 µM -2.58475031244528 0.00837553911660741 no 3308 0.00487247699166515 1075 909016 SGTC_444 curcumin 90.4 µM -2.61208994992466 0.00781163227080419 no 3309 0.00449952867526637 1073 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3201 9113999 49.47 µM -2.61603967570823 0.00773298994474997 no 3310 0.00444781101733094 1078 16649224 SGTC_5 0352-0601 109.883 µM -2.61614539646874 0.00773089456593365 no 3311 0.00444643403736008 1074 762456 SGTC_3039 9090270 49.47 µM -2.62584953313473 0.00754067459234921 no 3312 0.00432165079432918 1079 17173750 SGTC_2778 tioconazole 65.09 nM -2.62931046930857 0.00747383762639102 no 3313 0.00427791046764446 1056 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.64036000347838 0.00726393117064246 no 3314 0.00414090006094804 1077 688664 SGTC_1937 st074714 47.2 µM -2.65022612369988 0.00708091667064955 no 3315 0.00402189570907387 1085 17250970 SGTC_1817 st052116 64.4 µM -2.66349336833577 0.00684123170314774 no 3316 0.00386669680984893 1087 4361398 SGTC_1688 st021091 57.6 µM -2.66707157617424 0.00677782758855194 no 3317 0.00382576871491866 1089 3656366 SGTC_263 alizarin 107.927 µM -2.66966734744373 0.00673215725301185 no 3318 0.0037963213521156 1076 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_75 0159-0059 199.013 µM -2.71388515078485 0.00599488773637821 no 3319 0.00332496081730166 1083 5377270 SGTC_3306 9127676 59.7925 µM -2.7547460611258 0.00537817223277067 no 3320 0.00293688521657327 1085 41905287 SGTC_2250 alverine citrate 130 µM -2.75994887159592 0.00530383906857851 no 3321 0.00289052041323596 1066 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2135 5326629 150.42 µM -2.80852700082623 0.00465269483473845 no 3322 0.00248843543984351 1084 5020077 SGTC_339 3091-4833 71.4 µM -2.82363464155507 0.00446526626364493 no 3323 0.00237412388245141 1072 3240077 SGTC_848 0368-0089 85.6 µM -2.87087221123264 0.00392196759659515 no 3324 0.00204670483463173 1084 762535 SGTC_1366 1683-0113 21.9 µM -2.88580120601762 0.00376302197780762 no 3325 0.00195209337836983 1088 708623 SGTC_2814 7977482 42.97 µM -2.93036215889668 0.0033223708159546 no 3326 0.00169283581783076 1086 6456762 SGTC_2900 5328528 85.29 µM -2.94860989820292 0.00315573222494669 no 3327 0.00159603311739029 1085 795359 SGTC_3091 9116372 49.47 µM -2.95300984038512 0.00311669470641234 no 3328 0.00157345965646592 1089 17169793 SGTC_1696 st025591 34.7925 µM -3.01608430760145 0.00260291750750247 no 3329 0.00128031026306325 1090 2787147 SGTC_1814 st052110 31.539 µM -3.01830010465653 0.00258634775955668 no 3330 0.00127098519576743 1091 674163 SGTC_1061 3448-9325 110 µM -3.03029296270343 0.00249830796089206 no 3331 0.00122158313629665 1087 723482 SGTC_89 0302-0250 142.109 µM -3.04824897461971 0.00237155230465424 no 3332 0.00115089566311764 1094 4203518 YLR208W SEC13 SGTC_847 0342-0274 5.54 µM -3.11947029162774 0.00192412026503278 no 3333 0.000905882650018144 1092 18097 SGTC_3211 9128781 49.47 µM -3.16457849494027 0.00168192992990781 no 3334 0.000776538816377506 1073 17194361 SGTC_2939 9044578 71.43 µM -3.16567093894235 0.00167642505591434 no 3335 0.000773628600255032 1091 2653634 SGTC_1845 st056753 3.01 µM -3.2019147900011 0.00150283663476531 no 3336 0.000682586869634115 1090 5375839 SGTC_1512 0259-0544 12.2 µM -3.24060916296314 0.00133574084126257 no 3337 0.000596372969505788 1090 18476 SGTC_3243 9134147 49.47 µM -3.28305787960954 0.00117209377187602 no 3338 0.000513437898902702 1081 24282180 SGTC_96 0929-0093 37.281 µM -3.29323396910162 0.00113569464830969 no 3339 0.000495210095795692 1094 6991579 SGTC_374 0880-0231 82.3 µM -3.40022502216071 0.000810979191990197 yes 3340 0.000336652095101169 1078 6833587 SGTC_1125 tnp00248 1.32998 µM -3.40856913530537 0.000789649578732849 yes 3341 0.000326522675620274 1091 24207736 SGTC_1282 0886-0010 32.4 µM -3.41459898725282 0.000774558601168753 yes 3342 0.000319379893040877 1091 2836211 YNL267W PIK1 SGTC_90 0870-0863 4.608 µM -3.44054584128663 0.000712603357921089 yes 3343 0.000290271042625266 1094 1738164 SGTC_1334 1486-0610 236 µM -3.44615181051308 0.000699832461407497 yes 3344 0.000284315410444001 1093 3742339 SGTC_3340 9146634 11.102 µM -3.45962328488299 0.000670001340051405 yes 3345 0.00027046579360169 1091 4907387 SGTC_1850 st056238 17 µM -3.47863752681693 0.000629889592898941 yes 3346 0.000251984882699208 1090 5393177 SGTC_2929 9013348 24.6 µM -3.48787169230472 0.000611220163268217 yes 3347 0.000243440832068938 1092 2995952 SGTC_2682 pyrogallin 40.03 µM -3.5501324065299 0.000498092393907207 yes 3348 0.000192518721247995 1092 822798 An ATP competetive kinase inhibitor. SGTC_1358 1509-0022 2.48 µM -3.56784842418773 0.000469641947937042 yes 3349 0.000179962301113356 1093 3258434 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -3.74117223364744 0.000260617375154823 yes 3350 9.1581969789757e-05 1091 6708514 SGTC_2815 7968870 71.43 µM -3.85168504139279 0.000176749000289861 yes 3351 5.86539194403186e-05 1093 2977326 YHR190W ERG9 SGTC_2806 7952793 58.44 µM -4.13477312252282 6.24434182233959e-05 yes 3352 1.77652735162996e-05 1094 2972490 SGTC_3191 9110352 49.47 µM -4.25846058135888 3.88196173726153e-05 yes 3353 1.0291975342107e-05 1093 17122424 SGTC_87 0100-0052 35.5 µM -4.78368459243232 4.47833926680979e-06 yes 3354 8.60553421414945e-07 1094 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2810 7959871 45.46 µM -4.83573319908395 3.57061297344086e-06 yes 3355 6.63278760498409e-07 1092 2974535 SGTC_1934 st074720 32.6 µM -6.04862140535202 9.5744407221848e-09 yes 3356 7.30452560317821e-10 1095 17250992