SGTCid condition conc unit YKR011C|YKR011C.score YKR011C|YKR011C.strain.pval YKR011C|YKR011C.strain.significant YKR011C|YKR011C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1071 trifluoperazine 6.31 µM 7.43789509350995 1.5940205992201e-15 yes 1 5.11511242026914e-14 2 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_632 0781-2353 4.65 µM 7.36329605261334 2.99531174973244e-15 yes 2 8.97119189153258e-14 5 6811515 YHR007C ERG11 SGTC_2099 5377090 177.372 µM 5.64488366351138 1.11290875374372e-09 yes 3 8.26464906505217e-09 4 2243829 SGTC_833 3852-0053 558 µM 5.48405220487972 3.12892657615893e-09 yes 4 2.07846006028308e-08 3 3123681 SGTC_2723 salbutamol 83.58 µM 5.37388527847644 6.24872399482575e-09 yes 5 3.85289476993614e-08 1 9884233 β2-adrenoceptor agonist SGTC_3306 9127676 59.7925 µM 5.32876238633238 8.26343066773271e-09 yes 6 4.94421317633328e-08 6 41905287 SGTC_2969 9091408 28.7 µM 5.16536146316083 2.23130245529146e-08 yes 7 1.19987357239236e-07 8 4286311 SGTC_2326 6164455 177.58 µM 4.8020787632919 1.82901517392737e-07 yes 8 7.85134501119355e-07 9 2888790 SGTC_2695 st077686 51.995 µM 4.63561090911671 4.5707484441212e-07 yes 9 1.7794242114684e-06 21 2876092 SGTC_1529 apigenin 74 µM 4.57364571094367 6.37829426807727e-07 yes 10 2.39655034047496e-06 19 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2299 7976368 114.88 µM 4.50680447417601 9.09444971791763e-07 yes 11 3.29056126258077e-06 19 2979718 SGTC_2403 6032726 181.2 µM 4.42743906937932 1.37714382761563e-06 yes 12 4.76792485842455e-06 27 2881040 SGTC_2319 6033012 152.6 µM 4.2350024927102 3.66095373043042e-06 yes 13 1.14274585303151e-05 28 847246 SGTC_1608 st001473 40.5 µM 4.17966986380333 4.81351429653045e-06 yes 14 1.45966295968536e-05 30 7292267 SGTC_6 0844-0013 19.835 µM 4.03464945499122 9.70916262767133e-06 yes 15 2.73419373079324e-05 79 1584900 SGTC_2947 9072639 7.68 µM 3.96401636371151 1.3552747315335e-05 yes 16 3.68495986388567e-05 42 16488146 SGTC_2323 6148992 148.28 µM 3.9240800998632 1.63263943188354e-05 yes 17 4.35308834697498e-05 37 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1853 st056710 91.2 µM 3.89172902927643 1.89604180981607e-05 yes 18 4.97661857986659e-05 26 269167 SGTC_2848 9016370 25.97 µM 3.52966377207494 9.36569598590243e-05 yes 19 0.000208044044871643 40 7894410 SGTC_1951 sophoraflavanone G 9.2 µM 3.46028411835817 0.000125172683245789 yes 20 0.000269802857229383 50 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2808 7946468 45.46 µM 3.45673883726149 0.000127024260023784 yes 21 0.000273377227869461 41 2970879 SGTC_1954 st077032 68.9 µM 3.43463634367775 0.000139159396819663 yes 22 0.000296674749659289 37 698907 SGTC_2611 pyromycin 23.93 µM 3.42249698997598 0.000146278351412757 yes 23 0.000310243924100759 59 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1651 st011928 86.1 µM 3.40106218045217 0.000159688101488792 yes 24 0.000335622787345952 25 720198 SGTC_2696 st077691 74.316 µM 3.3772692679409 0.000175916639025962 yes 25 0.00036604672331599 46 757133 SGTC_1852 st056254 31.4 µM 3.24197989343549 0.00030154419478892 yes 26 0.000593511983936973 29 442583 SGTC_1228 0124-0032 52.5 µM 3.21487027296225 0.000335146453727393 yes 27 0.00065251742535793 45 X1228 SGTC_821 1114-0266 29.2 µM 3.19481899200568 0.000362204883474853 yes 28 0.00069959282334607 50 3123235 SGTC_1204 4049-0315 18.3 µM 3.18416227578167 0.000377398478589886 yes 29 0.000725868015319689 65 588402 SGTC_2585 alliin 100 µM 3.16994194031811 0.000398595455967101 yes 30 0.000762346999945706 60 87310 A garlic compound which reacts with lipids. SGTC_2394 5221648 200 µM 3.16959996605742 0.000399118553465071 yes 31 0.000763244693103788 58 788586 SGTC_1830 st055982 50.3 µM 3.16368673863079 0.000408265013724844 yes 32 0.000778921880382344 57 455313 An antimicrobial agent. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 3.08098291264669 0.000558325877890589 yes 33 0.00103159244292686 79 551469 SGTC_1509 1326-1131 80 µM 3.07605599626135 0.000568705493194397 yes 34 0.00104879224053844 39 768313 SGTC_481 bay k-8644 50 µM 3.06839167916544 0.000585207119111922 yes 35 0.00107607167657602 63 2303 A calcium channel antagonist. SGTC_3280 9140961 49.47 µM 3.06150653907975 0.000600407286701997 yes 36 0.00110113090809077 43 4901226 SGTC_337 1315-0038 354 µM 2.97075304808332 0.000837929049543044 yes 37 0.00148535277546438 62 1626437 SGTC_475 α-linolenic acid 10 µM 2.95937981876491 0.0008731387195732 yes 38 0.00154129455786142 59 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2814 7977482 42.97 µM 2.93987663374995 0.000936699171887623 yes 39 0.00164171474274252 115 6456762 SGTC_1207 2099-0101 141 µM 2.89940438745275 0.00108236550839377 no 40 0.00186936176688039 74 5837381 SGTC_1702 st027038 51 µM 2.88595102370324 0.00113520743278683 no 41 0.00195116439075854 60 5521182 SGTC_1258 0671-0043 57.1 µM 2.88184547921514 0.00115179765423856 no 42 0.00197676780461695 84 4298767 SGTC_2676 harmalol 100 µM 2.87068361092179 0.00119803088119766 no 43 0.00204792624788003 52 5459187 A monoamine oxidase inhibitor SGTC_936 3005-4620 401 µM 2.82694385977123 0.00139604363826903 no 44 0.00234972829607404 97 777207 SGTC_326 k292-0812 17.5 µM 2.7923727970823 0.00157322009670496 no 45 0.0026161517701886 40 3579357 SGTC_620 0109-0052 432 µM 2.78789669521292 0.0015976010786243 no 46 0.00265257289681953 72 493037 SGTC_1067 clotrimazole 1.36 µM 2.7818500770572 0.00163108336249236 no 47 0.00270250011366943 108 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2280 7785178 200 µM 2.77327297668782 0.00167967494515011 no 48 0.00277477734894509 53 2954328 SGTC_2271 7849410 118.62 µM 2.75572382345834 0.00178322648116883 no 49 0.00292812107511463 62 972430 SGTC_504 lovastatin 124 µM 2.70217300174746 0.00213611755998082 no 50 0.00344439541093694 56 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2771 fluoxetine 41.05 µM 2.69109875307267 0.00221656298896923 no 51 0.00356085551272636 80 3386 A selective serotonin reuptake inhibitor. SGTC_1855 st056195 39.6 µM 2.66169037039113 0.00244368873015904 no 52 0.00388746807697284 90 4028379 SGTC_3227 9130768 49.47 µM 2.66121633138132 0.00244751627327716 no 53 0.00389294577076624 51 17720899 SGTC_3322 9139058 2.11 µM 2.65662316992276 0.0024848847442389 no 54 0.00394638064023442 107 4908926 YPR165W RHO1 SGTC_530 4358-1714 28 µM 2.6481643710101 0.00255505538835117 no 55 0.00404650826026261 131 1564641 SGTC_679 0422-0091 41.4 µM 2.59110859238432 0.00307704218090717 no 56 0.00478336492011144 130 627384 YHR062C RPP1 SGTC_2718 lomofungin 53.02 µM 2.58737371394995 0.00311434766406542 no 57 0.00483553193815215 71 5351222 A RNA synthesis inhibitor. SGTC_3005 9076496 71.4286 µM 2.5774320677569 0.00321564133833435 no 58 0.00497687222507774 62 21368410 SGTC_1556 plumbagin 1.48 µM 2.57361753827011 0.00325528718300804 no 59 0.0050320728061754 80 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_3239 9133757 49.47 µM 2.56956516275645 0.00329788618596229 no 60 0.0050913119659092 34 17036923 SGTC_2404 5161160 200 µM 2.55053912710159 0.00350466681960996 no 61 0.00537782251546296 116 2831543 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.54789910305095 0.00353426116547982 no 62 0.00541869051385749 107 688801 SGTC_3225 9130819 49.47 µM 2.52612529671298 0.00378702835119285 no 63 0.00576641706023238 97 4547121 SGTC_1946 st076057 65.1 µM 2.51364554446542 0.00393910132354763 no 64 0.0059745230896026 52 953009 SGTC_1826 st055655 41.6 µM 2.50839771113402 0.00400466661734746 no 65 0.00606400382171626 137 676168 SGTC_1392 3455-1037 33.9 µM 2.48610831616162 0.00429416658540993 no 66 0.00645743251169014 96 981132 SGTC_421 streptovitacin 30 mM 2.47538166544053 0.00444004367095421 no 67 0.00665469296764868 127 91467 include heat shock SGTC_2942 9052777 62.25 µM 2.47441736992341 0.00445337201788431 no 68 0.00667268439983112 149 6469503 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.47204443900094 0.00448632260376654 no 69 0.00671714076989098 326 16725076 SGTC_3013 9080133 71.4286 µM 2.46918630523373 0.00452629966967391 no 70 0.00677103466495819 121 17050193 SGTC_2291 7917025 104.35 µM 2.4523109122165 0.00476888676097792 no 71 0.00709709792044016 177 2964612 SGTC_495 decylubiquinone 155 µM 2.45017103125574 0.00480046202075965 no 72 0.00713941863839469 141 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2293 7624732 200 µM 2.44329687723052 0.00490315931236754 no 73 0.00727687982904217 127 894453 SGTC_2091 4-phenylthiadiazole 200 µM 2.42961780761978 0.00511336114177106 no 74 0.00755737596226734 124 270010 SGTC_3304 9125678 46.087 µM 2.41749291335423 0.00530634769761285 no 75 0.00781391914974789 170 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_288 1315-0019 35.1 µM 2.41748040748733 0.00530655004727738 no 76 0.00781418766125096 125 6811474 SGTC_1657 st012939 43.4 µM 2.41256574867115 0.0053866043556009 no 77 0.00792034005192935 95 24207257 SGTC_3074 9116018 49.47 µM 2.40928205827898 0.00544068858839598 no 78 0.00799196975127237 102 17027303 SGTC_2031 5180455 200 µM 2.39567641157011 0.00566995896200948 no 79 0.00829486445110315 100 29949 SGTC_3222 9128301 49.47 µM 2.38261197320401 0.00589814088959414 no 80 0.0085951515914299 127 4911358 SGTC_2368 9071271 200 µM 2.37695657428697 0.0059994178628353 no 81 0.00872807153448157 151 27209959 SGTC_1829 berberine 14.4 µM 2.36578362759784 0.0062040445306468 no 82 0.00899597805032477 122 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3290 9121031 71.43 µM 2.36044180225245 0.00630404355492921 no 83 0.00912659105185003 107 17014854 SGTC_949 1165-0505 146 µM 2.35027564103749 0.00649830297328739 no 84 0.00937975660947398 157 6244267 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 2.34757897095207 0.00655071266239772 no 85 0.00944793352873551 118 7104 SGTC_670 4204-0025 119 µM 2.3360902645186 0.00677820720058421 no 86 0.00974326879944691 154 719039 SGTC_401 neomycin 50 µM 2.32282922612891 0.00704945142280577 no 87 0.0100941641799364 113 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3035 9091303 49.47 µM 2.31492905936956 0.00721555749011085 no 88 0.010308407366884 83 25237002 SGTC_1937 st074714 47.2 µM 2.30876649921126 0.00734751607101307 no 89 0.0104782709809133 166 17250970 SGTC_2211 7117706 200 µM 2.30449446910449 0.00744023684133423 no 90 0.0105974512347412 117 822771 SGTC_2516 gossypol 71.55 µM 2.30355278890214 0.00746081334336785 no 91 0.010623880314593 152 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_222 nsc-310342 10.666 µM 2.30292704575998 0.00747451406693668 no 92 0.0106414740773334 63 432556 SGTC_1534 6-azauridine 81.6 µM 2.3024555353575 0.00748485248436659 no 93 0.0106547481018436 173 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1772 st048439 82.2 µM 2.29840417672176 0.00757420364531379 no 94 0.0107693980102306 178 2927068 YDL195W SEC31 SGTC_1210 3013-0140 750 nM 2.29529932068128 0.0076433145063016 no 95 0.0108579882628448 102 905973 SGTC_2833 9001315 45.46 µM 2.28034442347096 0.00798402953198733 no 96 0.0112936345130111 199 2989378 SGTC_255 tunicamycin 200.472 nM 2.27577854957034 0.00809068039597232 no 97 0.0114296336102104 223 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1980 st071811 45.7 µM 2.26853042610788 0.00826255611149939 no 98 0.0116484483537748 145 4974850 SGTC_1887 st057648 70.8 µM 2.26297507803322 0.00839645359916618 no 99 0.0118186128127804 141 688672 SGTC_2589 lobaric acid 100 µM 2.25968200574673 0.00847672074344572 no 100 0.0119204969412368 172 73157 A novel microtubule depolymerizer. SGTC_2231 micatex 6.853 µM 2.25292741402637 0.00864347069694105 no 101 0.01213186301548 112 20737 An antifungal of unknown mechanism. SGTC_1005 4092-0690 4.4 µM 2.24760632962442 0.00877685079465989 no 102 0.0123006518038294 153 1529343 SGTC_2979 9012552 45.46 µM 2.2472056690688 0.00878696654501304 no 103 0.0123134430264768 92 17100905 SGTC_1474 0330-0125 5.35 µM 2.2428258581998 0.00889821486013162 no 104 0.0124540231539233 135 X1474 SGTC_3057 9095946 49.47 µM 2.24181817617049 0.00892398420252206 no 105 0.0124865630066087 120 24540043 SGTC_3000 9075062 71.4286 µM 2.24143253002259 0.00893386357600922 no 106 0.0124990356736529 148 17057871 SGTC_816 0325-0417 81.3 µM 2.24121317392046 0.00893948725257012 no 107 0.0125061349571131 135 68101 SGTC_2279 7948423 32.93 µM 2.22408944179527 0.00938817411225258 no 108 0.0130712135602179 118 1247112 SGTC_265 mycophenolic acid 32.932 µM 2.21689533939185 0.00958247882955303 no 109 0.0133151221622519 177 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_995 3931-2021 34.6 µM 2.21518916386464 0.00962907318554005 no 110 0.0133735416729639 160 730143 SGTC_1553 gossypol 38.6 µM 2.19744335388425 0.0101255587458408 no 111 0.0139943989384501 73 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1660 st012960 28.1 µM 2.197062775347 0.0101364466499022 no 112 0.0140079815924341 182 24207266 SGTC_782 0083-0095 30.5 µM 2.19685197240372 0.0101424818687048 no 113 0.0140155099311963 201 3591729 An indicator and reagent. SGTC_2005 4024620 188 µM 2.19549462805038 0.0101814173224346 no 114 0.0140640679120948 166 236743 SGTC_615 k087-0205 167 µM 2.18304596204963 0.0105446312172573 no 115 0.014516212716688 140 9642773 SGTC_2961 9083290 32.55 µM 2.16572165967397 0.0110688636887863 no 116 0.0151662314371328 151 17741490 SGTC_2956 9076196 2.52 µM 2.1642407892921 0.0111147088102379 no 117 0.0152229371659107 179 16423868 SGTC_237 nikkomycin 200 µM 2.16411151393837 0.0111187187715462 no 118 0.0152278960310714 179 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_3274 9138298 49.47 µM 2.1615192268504 0.0111993942735391 no 119 0.0153276266902417 167 17015756 SGTC_2436 5633522 8.09 µM 2.15919279690759 0.011272228754863 no 120 0.0154176063284752 184 5724242 SGTC_431 k089-0097 107 µM 2.15100409416798 0.0115318805426387 no 121 0.0157379382659652 258 5499420 SGTC_1497 4476-2978 41.3 µM 2.14446960151526 0.0117427908377973 no 122 0.0159976392994781 225 1528379 SGTC_1077 5-fluorocytosine 377 nM 2.14152483544471 0.0118389265834059 no 123 0.016115868945487 165 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1554 st069299 38.7 µM 2.13969483548132 0.0118990127446038 no 124 0.0161897183509718 188 24207999 SGTC_2846 9008642 19.48 µM 2.12890526903165 0.0122586822636315 no 125 0.0166310493823322 168 2992898 SGTC_2191 5911152 200 µM 2.12816209883652 0.0122837989619478 no 126 0.0166618230324909 172 2875902 SGTC_2722 naftopidil 47.16 µM 2.12432089584758 0.0124143309583299 no 127 0.0168216597939848 171 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2754 granisetron 64.02 µM 2.12196498552775 0.0124949825919885 no 128 0.0169203392505068 209 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_84 0443-0269 128.823 µM 2.12126551188135 0.0125190153725824 no 129 0.0169497324701946 199 6150058 SGTC_403 arphamenine a 50 µM 2.11234775265479 0.0128289402693102 no 130 0.0173283164137994 199 5487158 An arginine aminopeptidase inhibitor. SGTC_73 0327-0325 16.231 µM 2.11120386430671 0.012869170893028 no 131 0.0173773964173464 263 53298 SGTC_1919 st067113 52.3 µM 2.10661412056117 0.013031691620441 no 132 0.0175755208728236 223 1268243 SGTC_474 dl-dihydrosphingosine 5 µM 2.09650650910636 0.013395864489757 no 133 0.0180186415581437 209 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2885 9057732 51.95 µM 2.09587264273955 0.013418992421985 no 134 0.018046745063345 186 6471414 SGTC_3276 9139060 49.47 µM 2.09422797865806 0.0134791622617397 no 135 0.0181198382665605 124 4870619 SGTC_2039 Aminomethylbenzodioxan 200 µM 2.08265214444622 0.0139092886124484 no 136 0.0186414712462526 147 15053 SGTC_2207 7258803 200 µM 2.06366420197124 0.0146404613029782 no 137 0.0195247828708405 138 3666799 SGTC_1709 st033179 39.1045 µM 2.0636343676696 0.0146416356735377 no 138 0.01952619824805 205 573381 SGTC_1956 st077085 54 µM 2.05958932163993 0.0148016135288992 no 139 0.0197189089657622 220 24208685 SGTC_2429 5902844 64.44 µM 2.05651718338464 0.0149241160658343 no 140 0.0198663458590829 244 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_513 4245-1575 41.7 µM 2.04009738880046 0.0155937428502317 no 141 0.0206703133770179 370 719745 SGTC_3352 9151559 45.5865 µM 2.03284207284072 0.0158977434558695 no 142 0.0210342404877367 200 17159339 SGTC_566 0958-0068 16.5 µM 2.02934439598426 0.0160461037526908 no 143 0.0212116121766697 185 6815365 SGTC_2883 9059145 45.46 µM 2.02118371573891 0.0163968745275259 no 144 0.0216303753885602 169 16476510 SGTC_1069 diphenylcyclopropenone 8.49 µM 2.00278321811717 0.0172119460135158 no 145 0.022600280960664 262 65057 A dermal irritant. YDR527W RBA50 SGTC_2614 arthonioic acid 13.39 µM 1.99290979054715 0.0176633995424823 no 146 0.0231356630263764 208 6710684 SGTC_2276 7947513 42.08 µM 1.98142028115188 0.018201431637936 no 147 0.0237720806049069 227 2105100 SGTC_2273 7815444 169.05 µM 1.97890168559886 0.0183212211807284 no 148 0.0239135382272817 226 2824616 SGTC_2835 9006588 71.43 µM 1.97765061125062 0.0183809740822964 no 149 0.0239840677466654 254 2345538 SGTC_2221 6807166 181.081 µM 1.97751581486876 0.0183874220240109 no 150 0.0239916773355247 123 674925 SGTC_2093 5331342 194.4 µM 1.97561660721097 0.0184784750149757 no 151 0.0240991081405687 215 33839 SGTC_1286 0929-0070 131 µM 1.96792695446265 0.0188510717796929 no 152 0.0245382214594079 246 1420408 SGTC_39 0986-0283 58.349 µM 1.96321811802828 0.0190823759264402 no 153 0.0248104174960462 274 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2924 9010168 62.78 µM 1.94616449082252 0.019940371645375 no 154 0.0258174919230229 257 2993929 SGTC_1967 st070177 51.4 µM 1.94435343536501 0.0200333822786487 no 155 0.0259264224934291 205 5729214 SGTC_1988 st071872 53.4 µM 1.94382850916126 0.0200604096831584 no 156 0.0259580673090873 195 16414116 SGTC_2878 9043973 25.97 µM 1.93537300330986 0.0205000462712909 no 157 0.0264722698499798 197 6465167 SGTC_1213 1315-0166 115 µM 1.93252220647802 0.0206500993449515 no 158 0.0266475419370485 211 768401 SGTC_231 b-estradiol 524 µM 1.92890565588867 0.0208417959595408 no 159 0.0268712877817785 176 450 A steroid. SGTC_1159 4092-0538 61.2 µM 1.92365497721208 0.0211227901420425 no 160 0.0271989224825222 264 717301 SGTC_2234 tolnaftate 200 µM 1.91531134325602 0.0215758967753616 no 161 0.0277264049241372 135 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2724 maprotiline 69.64 µM 1.90642587728811 0.0220674321400178 no 162 0.0282974870055758 212 4011 A tricyclic antidepressant. SGTC_3298 9116858 71.43 µM 1.89873597961269 0.0225004280429038 no 163 0.0287995991968912 228 2506942 SGTC_1817 st052116 64.4 µM 1.88699144734116 0.0231755423253773 no 164 0.0295807380048995 231 4361398 SGTC_1778 st046819 58.9 µM 1.88255506544218 0.0234349598718313 no 165 0.0298803453840944 315 671715 SGTC_2163 5671233 125 µM 1.86977403040686 0.0241960257449406 no 166 0.0307576020619284 285 701023 SGTC_1564 D-Arginine 115 µM 1.84931782139173 0.0254572724158797 no 167 0.0322059669419427 284 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_3185 9108267 49.47 µM 1.84224442310132 0.0259060069990679 no 168 0.0327197025827669 288 4910486 SGTC_2580 diallyl disulphide 81.36 µM 1.8410149601133 0.025984675008569 no 169 0.0328096832118579 262 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1502 4534-4282 27.7 µM 1.82622610689025 0.0269467084093823 no 170 0.033908105205481 223 3278949 SGTC_322 k048-0136 19.3 µM 1.81516773942204 0.0276853430295207 no 171 0.0347490678796756 252 6823282 SGTC_18 0111-0177 500 nM 1.80829942072938 0.0281525453121361 no 172 0.0352799559952252 403 721752 SGTC_1685 st024049 53.0905 µM 1.80741828220381 0.0282129551609682 no 173 0.0353485427596071 245 1941139 SGTC_2325 6158266 200 µM 1.80323619548908 0.0285011475534277 no 174 0.0356755641257068 285 3623240 SGTC_152 4469-0003 551.229 µM 1.79770874742082 0.028885803900026 no 175 0.036111587249355 267 697280 SGTC_2409 alverine citrate 63.97 µM 1.79754558352175 0.0288972237634631 no 176 0.0361245241658435 315 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1141 3253-0389 52.6 µM 1.79430519576942 0.0291247973651015 no 177 0.0363822346282682 238 5402031 SGTC_1976 st070609 63.5 µM 1.78560683499203 0.0297430590281392 no 178 0.0370814697237287 282 682556 SGTC_3120 9124077 49.47 µM 1.7784752572019 0.0302580455830369 no 179 0.0376629160759958 243 18774327 YGL155W CDC43 SGTC_1254 0550-0035 264 µM 1.77486048618196 0.0305218851748044 no 180 0.0379604630382051 311 15121435 SGTC_1603 st002045 67.8 µM 1.7694938035777 0.0309171080688481 no 181 0.0384057519677085 271 5887985 SGTC_2343 7990716 14.84 µM 1.76820140540669 0.031012915388589 no 182 0.0385136196713283 299 6456862 SGTC_3349 9149703 23.001 µM 1.76623857423941 0.0311588926512057 no 183 0.0386779160106713 274 4910494 SGTC_1667 st014849 34.6 µM 1.76474489211494 0.0312703593944655 no 184 0.0388033250498793 265 5348460 SGTC_1342 1486-1464 234 µM 1.76374962551329 0.0313448145646907 no 185 0.0388870710158047 289 3253938 SGTC_1845 st056753 3.01 µM 1.76327653803767 0.031380257262189 no 186 0.0389269301901603 327 5375839 SGTC_91 0417-1751 58.384 µM 1.76020952966716 0.0316108355230818 no 187 0.0391861433997224 385 6795624 SGTC_3077 9117319 49.47 µM 1.7561146787154 0.0319208681685682 no 188 0.0395344146160455 235 17154678 SGTC_2134 5324836 1.464 µM 1.75422110912055 0.0320650824974443 no 189 0.0396963137661226 235 699272 SGTC_3037 9091026 49.47 µM 1.75028546401165 0.0323665426386329 no 190 0.040034533945454 462 25236398 YIL048W NEO1 SGTC_950 1165-0508 94.1 µM 1.74115547680898 0.0330748879411718 no 191 0.0408281645899465 318 6148369 SGTC_2892 9047358 58.44 µM 1.74075779243631 0.0331060301081495 no 192 0.0408630216302998 227 6466771 SGTC_1418 3966-3099 2.4 µM 1.74005624797321 0.0331610260766518 no 193 0.0409245708694365 327 740335 SGTC_917 harmaline 728.087 nM 1.72765753193615 0.0341454768885882 no 194 0.0420248208200735 339 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2583 asiatic acid 100 µM 1.726632063804 0.0342279631396371 no 195 0.0421168818272614 300 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2766 oltipraz 83.91 µM 1.72550170792614 0.0343190760253238 no 196 0.0422185481315144 300 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1029 k015-0030 64.7 µM 1.72428898854047 0.0344170494095802 no 197 0.0423278430770046 325 2208316 SGTC_1208 2323-2347 50.3 µM 1.71971616105434 0.0347885489779378 no 198 0.042742024353456 287 5412760 SGTC_858 0438-0351 2.77 µM 1.7193782909677 0.0348161278935385 no 199 0.0427727562658825 338 2799119 SGTC_1978 st071761 42 µM 1.71802835502687 0.0349264966827011 no 200 0.0428957217228157 294 5147680 SGTC_1501 4491-0275 38.4 µM 1.69901997986213 0.0365113097542187 no 201 0.044657709555384 285 5104718 SGTC_729 4092-0585 94.1 µM 1.69272620596528 0.0370488392889559 no 202 0.0452537973381917 304 2169061 SGTC_2081 5214970 32.255 µM 1.69073317585443 0.0372203994583952 no 203 0.0454438875065343 310 2063512 SGTC_451 chloral hydrate 100 µM 1.6884350125904 0.0374190307274715 no 204 0.0456638770842584 416 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1674 st016616 23.6 µM 1.68464654819267 0.0377483587227185 no 205 0.0460283924519939 348 625830 SGTC_3279 9140807 49.47 µM 1.68418967440327 0.0377882337421579 no 206 0.0460725090673392 298 45595718 SGTC_2164 5685496 200 µM 1.68122441909574 0.0380478715924676 no 207 0.0463596660516903 322 759046 SGTC_2922 7999257 32.47 µM 1.65697736648594 0.0402259736610682 no 208 0.048762025568144 298 2988377 SGTC_819 1013-0258 27.7 µM 1.65694504749691 0.0402289430622121 no 209 0.0487652928428014 367 5753198 SGTC_781 4335-2806 94.4 µM 1.64664154228503 0.0411847226853903 no 210 0.0498158731835149 388 845254 SGTC_260 nsc-65238 3.989 µM 1.64583368222235 0.0412604337160452 no 211 0.0498990028162084 308 3246252 SGTC_1818 st052136 56.3 µM 1.64493873641539 0.0413444379345763 no 212 0.049991222795334 372 674169 SGTC_2951 9072950 58.06 µM 1.64278958837629 0.0415467342520274 no 213 0.0502132375592762 372 16488155 SGTC_1360 1598-0022 39.8 µM 1.64101088643962 0.0417147668625446 no 214 0.0503975776966409 438 761525 SGTC_2011 4012611 177 µM 1.6406489146167 0.0417490293779679 no 215 0.0504351574889143 362 2049887 SGTC_157 1348-1695 65.819 µM 1.63858993526178 0.0419443562564082 no 216 0.0506493449281489 448 5380510 SGTC_1690 st023502 41.2 µM 1.63845754696593 0.0419569406601603 no 217 0.050663141507421 314 24207482 SGTC_410 α-linolenic acid 100 µM 1.63707699010176 0.0420883541522662 no 218 0.0508071918743799 372 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_206 4546-0025 72.014 µM 1.63150169721701 0.0426224522998333 no 219 0.0513922510118462 426 6620745 YIL048W NEO1 SGTC_1774 st048371 48.465 µM 1.63109047271232 0.0426620625343074 no 220 0.0514356153466944 379 4242727 SGTC_1428 4049-0204 61.7 µM 1.62791432275739 0.0429690012638079 no 221 0.0517715269925866 352 X1428 SGTC_842 0271-0008 11.1 µM 1.62668151911531 0.0430886173561782 no 222 0.0519023778979098 375 1221709 SGTC_1373 2887-0003 58.5 µM 1.62409410708367 0.0433405427044168 no 223 0.0521778627359839 366 776948 SGTC_533 1222-0222 6.71 µM 1.62314482015632 0.0434332684278983 no 224 0.0522792251697534 389 3982874 SGTC_2060 5238662 140 µM 1.61876936552096 0.0438627322160636 no 225 0.052748447884226 360 790130 SGTC_369 0957-0393 4.5 µM 1.61828331283651 0.0439106503807496 no 226 0.0528007776188755 347 6997992 SGTC_1046 2001-0062 216 µM 1.61065631358821 0.0446681123519969 no 227 0.0536273262334616 371 739778 SGTC_1129 3453-1384 223 µM 1.6086862885858 0.0448654625478219 no 228 0.0538424777242964 415 1084452 SGTC_354 2783-3500 4.88 µM 1.60473353024454 0.0452635531107107 no 229 0.0542762297746557 392 6740761 SGTC_957 1187-1561 14.1 µM 1.60439974660734 0.0452972988617414 no 230 0.0543129834200744 404 1538454 SGTC_87 0100-0052 35.5 µM 1.60391425957425 0.0453464180519891 no 231 0.0543664766025791 606 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.60196556296136 0.0455440088620914 no 232 0.0545816124248113 382 5282309 SGTC_1907 st060210 83.7 µM 1.60186107867744 0.0455546227153307 no 233 0.0545931664628631 408 688793 SGTC_705 1124-0212 310 µM 1.59791565068049 0.045956869698273 no 234 0.0550308752444606 387 9554485 SGTC_254 nsc-64875 3.808 µM 1.59672038941419 0.046079291436568 no 235 0.0551640242979879 355 56993 SGTC_1636 st007707 68.9 µM 1.58882944788506 0.0468940887123907 no 236 0.0560494514818827 428 403051 SGTC_1625 st003711 30.1 µM 1.58600324685369 0.0471887098572661 no 237 0.0563692865144892 360 24207034 YER133W GLC7 SGTC_1825 st052143 62.6 µM 1.57818464545711 0.0480115057961575 no 238 0.0572615983259376 317 674173 SGTC_1298 1079-1278 263 µM 1.5767615122599 0.0481624981846945 no 239 0.0574252053130791 390 2840950 SGTC_2512 diallyl trisulfide 49.23 µM 1.57664366828288 0.0481750182762212 no 240 0.0574387694247825 310 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2549 cedrol 20.94 µM 1.57618922667621 0.0482233238781616 no 241 0.057491100297572 313 6708665 A sedative which affects the nervous system. SGTC_795 0685-0265 78 µM 1.5757517596889 0.0482698617354301 no 242 0.0575415118934879 400 302754 SGTC_2768 sulfasalazine 50.2 µM 1.57557798939161 0.048288357434166 no 243 0.0575615459943913 365 5384001 An antioxidant and salicylic acid derivative. SGTC_2984 9022109 38.96 µM 1.57421249082698 0.0484338952512899 no 244 0.0577191662922881 291 6459207 SGTC_334 1502-1024 68.5 µM 1.57317347805257 0.0485448703423608 no 245 0.0578393273528832 385 3296216 SGTC_880 0833-0487 87.2 µM 1.57254168805389 0.0486124500379439 no 246 0.0579124894919567 383 76075 SGTC_1555 citronellol 128 µM 1.57182089476315 0.0486896418397707 no 247 0.0579960471484331 320 8842 A terpine precursor. SGTC_2182 6325192 200 µM 1.56216008332703 0.0497337312700474 no 248 0.059125140734554 351 736248 SGTC_742 0kpi-0133 140 µM 1.55813373997254 0.0501741171722667 no 249 0.0596007740108447 404 2728852 SGTC_130 0136-0219 337.655 µM 1.55694405684775 0.0503048333957065 no 250 0.0597418840647128 388 234244 SGTC_1331 1472-0049 76.2 µM 1.55616961348033 0.0503900709694833 no 251 0.0598338824888094 391 24051409 SGTC_2136 5328288 199.296 µM 1.5541298721457 0.050615121860973 no 252 0.0600767205080202 327 262395 SGTC_1734 st037168 69.4 µM 1.55292359450324 0.0507485904325757 no 253 0.0602206946142181 401 708907 SGTC_455 paf C-16 10 µM 1.5528752803831 0.0507539419794898 no 254 0.0602264667201639 373 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.55037740012464 0.0510312341618473 no 255 0.0605254798357929 449 5024745 SGTC_1259 0671-0132 43 µM 1.5403755639392 0.0521536475660124 no 256 0.061734417139203 409 X1259 SGTC_2923 7992654 58.14 µM 1.53830873504781 0.0523880153898353 no 257 0.0619865724875015 403 2985126 SGTC_1081 sertraline 6 µM 1.53756606048443 0.0524724348157539 no 258 0.0620773756145337 453 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1031 k035-0009 16 µM 1.53510240271325 0.0527532509856115 no 259 0.0623793381028145 444 5180959 SGTC_193 1273-0060 1.558 µM 1.5287739221773 0.0534800596387491 no 260 0.0631602496535531 307 2847393 YHR072W ERG7 SGTC_1716 st033144 30.6155 µM 1.52765584222283 0.0536092889369629 no 261 0.0632990045913951 419 674617 SGTC_2317 5986382 200 µM 1.52720100139415 0.0536619308306579 no 262 0.0633555186943652 376 877883 SGTC_2318 6029776 164 µM 1.51690412742378 0.0548646507241034 no 263 0.0646454456975132 428 818325 SGTC_2345 9052315 157.45 µM 1.51461561995817 0.0551348307664864 no 264 0.0649348871022451 408 6469265 SGTC_879 0831-1030 162 µM 1.51324704509532 0.0552969055781707 no 265 0.0651084591474118 490 1549252 SGTC_2874 9043904 71.43 µM 1.51234851464939 0.0554035193754396 no 266 0.0652226125909943 332 4463428 SGTC_560 2332-1943 155 µM 1.51097250775894 0.0555671019503299 no 267 0.0653977277560803 401 21177716 SGTC_2519 cryptotanshinone 88.04 µM 1.51017964660478 0.0556615319301764 no 268 0.0654987953535518 367 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1746 st038117 42 µM 1.50467105735483 0.0563211075197964 no 269 0.0662043338347975 436 2898218 SGTC_2806 7952793 58.44 µM 1.50376153102532 0.056430600639514 no 270 0.066321389796716 431 2972490 SGTC_667 1498-1044 59 µM 1.5030016370527 0.0565222088786849 no 271 0.0664193109226624 417 6739982 SGTC_1051 3253-3903 78 µM 1.50163396399254 0.0566873825285145 no 272 0.066595833406667 457 5509239 SGTC_1211 1056-0033 32.3 µM 1.50131724976006 0.056725686223733 no 273 0.0666367627343966 421 6741922 SGTC_723 4182-0001 115 µM 1.49812504768158 0.0571128931820682 no 274 0.0670503822470086 406 744821 YLR208W SEC13 SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.49624588071631 0.0573418029571081 no 275 0.0672947962073198 323 77254 SGTC_300 r073-0011 5.04 µM 1.48969208400618 0.0581458037039264 no 276 0.0681526084860366 486 2735780 SGTC_2545 solidagenone 89.61 µM 1.48754306760953 0.0584113585896775 no 277 0.068435718647152 239 6708572 An anti ulcer agent SGTC_1889 st059080 5.18 µM 1.48634484197982 0.0585598368982092 no 278 0.0685939657061764 457 176925 Isolated from Daphnopsis sellowiana. SGTC_2781 5567276 71.43 µM 1.48560702709918 0.0586514106461503 no 279 0.0686915476241002 438 2853274 SGTC_1063 disulfiram 1.84 µM 1.48530894137544 0.0586884393635264 no 280 0.068731002193511 439 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3172 9105863 49.47 µM 1.47988617909038 0.0593652724755315 no 281 0.0694518123402653 300 2348785 SGTC_266 formosanin C 406 nM 1.47980444125113 0.0593755210676936 no 282 0.0694627215508421 458 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2597 laccaic acid a 100 µM 1.47925689271194 0.0594442104981091 no 283 0.0695358346172779 464 5491415 A textile dye. SGTC_676 falcarinol 140 µM 1.47674157523778 0.0597605552693229 no 284 0.069872461524916 470 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_316 k060-0003 58.6 µM 1.47413834720645 0.060089343634343 no 285 0.0702221727574255 421 6152314 SGTC_2315 7733312 200 µM 1.47214424832511 0.06034215551167 no 286 0.0704909644110892 397 726316 SGTC_2681 menadione 3.18 µM 1.46947524126842 0.0606818340843816 no 287 0.0708519662140702 433 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_93 0109-0045 59.227 µM 1.45869230506707 0.0620694016451553 no 288 0.0723249074796393 553 88733 SGTC_934 2950-0684 338 µM 1.4559685229311 0.0624237898547752 no 289 0.0727006606744272 472 1121253 SGTC_1264 0783-0040 158 µM 1.45096279790327 0.0630791909324346 no 290 0.073395109835507 421 2855798 SGTC_836 0330-0104 1.35 µM 1.43941293012506 0.0646118612738023 no 291 0.075016781526655 447 46494820 SGTC_2887 9044784 58.44 µM 1.43262736583934 0.0655257041150202 no 292 0.0759821784219843 462 6465546 SGTC_3033 9090887 49.47 µM 1.42541191691183 0.0665084037099759 no 293 0.0770190826512908 506 19325384 SGTC_1898 st060199 18.6 µM 1.41940865288302 0.0673346736788081 no 294 0.0778899556010714 435 688866 SGTC_1560 lithocholic acid 53.1 µM 1.41849613015496 0.067460962144167 no 295 0.0780229838561516 348 9903 A bile acid which acts as a detergent. SGTC_2017 5132927 60.65 µM 1.41674308725165 0.0677040878152178 no 296 0.0782790273370789 480 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1695 st026914 34.495 µM 1.41141123688439 0.0684477114759359 no 297 0.0790616957774198 469 3289191 SGTC_1731 st035964 63 µM 1.40034854985111 0.0700106875955453 no 298 0.0807044844798604 484 6739575 SGTC_471 1-acyl-paf 4 µM 1.39835572163444 0.0702951376069624 no 299 0.0810031363402834 467 16759367 SGTC_1865 st057639 52.2 µM 1.39612706483019 0.0706143008486655 no 300 0.0813381174902353 484 688818 SGTC_3099 9120367 49.47 µM 1.39109882106101 0.0713384795068245 no 301 0.0820977311737053 469 24824940 SGTC_557 1315-0110 16.2 µM 1.38926678004415 0.0716037463641474 no 302 0.0823758207898137 488 6833801 SGTC_3014 9081533 49.47 µM 1.38161595147779 0.072719718813658 no 303 0.0835448267390052 501 21367265 SGTC_343 4130-2827 29.8 µM 1.38054325031036 0.0728772449925437 no 304 0.0837097213057456 521 1118244 SGTC_2105 5350118 200 µM 1.37834811013561 0.0732004154295111 no 305 0.0840479179926428 485 2133313 SGTC_3121 9125696 49.47 µM 1.37634518061805 0.0734962440493602 no 306 0.0843573956415048 434 1235365 SGTC_3046 9092212 49.47 µM 1.37618918842535 0.0735193220980573 no 307 0.0843815342300712 462 25236637 SGTC_3301 9125354 19.7965 µM 1.37417838382704 0.0738173041004882 no 308 0.0846931548894424 440 41905162 SGTC_223 busulfan 5 mM 1.37084666798788 0.0743130630609863 no 309 0.0852113797676979 395 2478 A DNA alkylator. SGTC_2551 apiole 73.87 µM 1.3579878459198 0.0762503194451165 no 310 0.087233770405066 346 10659 A possible DNA adduct former. SGTC_1018 4259-0013 28.1 µM 1.3541029065125 0.0768431040940092 no 311 0.0878517745282459 497 6801262 SGTC_2389 9091542 195.52 µM 1.35310736673637 0.0769955713088957 no 312 0.0880106662773089 548 3626624 YOL127W RPL25 SGTC_2904 7225135 42.03 µM 1.35300875453997 0.0770106863031803 no 313 0.088026416796971 519 4446116 SGTC_2836 9010338 19.48 µM 1.34596265785806 0.0780965393509612 no 314 0.0891572798795915 473 2994051 SGTC_3282 9108498 15.4605 µM 1.34559715961974 0.0781531804597727 no 315 0.0892162340959752 531 16459645 SGTC_1112 tnp00069 1.16933 µM 1.34437427603116 0.0783429167648057 no 316 0.0894136939262516 583 145826 SGTC_1153 4055-0057 267 µM 1.33705111918013 0.0794864556397551 no 317 0.0906029755875554 521 882706 SGTC_592 k241-0073 46.5 µM 1.33652087972811 0.0795697424207763 no 318 0.0906895402582449 543 4230158 SGTC_2694 st077685 81.9 µM 1.33210601686095 0.0802657677352161 no 319 0.0914126767309766 522 2838096 SGTC_1950 st077106 7.18 µM 1.33194661094255 0.0802909846741052 no 320 0.0914388664861938 527 13831864 SGTC_633 0437-0093 97.7 µM 1.33097974233203 0.0804440650561016 no 321 0.0915978383158346 489 2831118 SGTC_2155 5570423 76 µM 1.32933858037188 0.0807044082063665 no 322 0.0918681456639899 507 797402 SGTC_1783 st039459 87.517 µM 1.32814892242762 0.0808935251488124 no 323 0.0920644571547864 577 729761 SGTC_2270 7924575 90.91 µM 1.325862248587 0.081257971212029 no 324 0.0924426647694344 564 1262135 SGTC_2733 amorolfine 100 µM 1.32156308552168 0.0819465159807882 no 325 0.0931568412335286 401 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1876 myriocin 605 nM 1.3193412150911 0.0823040847893497 no 326 0.093527532420388 525 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1784 st039334 36.3 µM 1.31879070216536 0.0823928609866365 no 327 0.0936195467581749 534 3496984 SGTC_777 1315-0167 517 µM 1.31879054235585 0.0823928867681223 no 328 0.0936195734789046 510 4221767 SGTC_806 3966-4455 5.86 µM 1.31710287884693 0.0826654902525473 no 329 0.0939020710917638 466 714982 SGTC_489 paxilline 115 µM 1.30448614878769 0.0847249778790025 no 330 0.0960339395744662 499 105008 A toxic potassium channel blocker. SGTC_117 lucigenin 22.078 µM 1.29966952612226 0.0855212855789816 no 331 0.0968571295946476 605 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1214 0358-0031 63.7 µM 1.29937259184755 0.0855705590049129 no 332 0.0969080464897073 550 4301366 SGTC_2470 5664817 21.68 µM 1.2974034625478 0.0858978553792618 no 333 0.0972462008867662 522 2859561 SGTC_453 enantio-paf c16 10 µM 1.29378684416084 0.0865014262165803 no 334 0.0978695290687186 724 13871343 A lipid and platelet activating factor SGTC_1677 st019204 53.9 µM 1.29073218307217 0.0870136782635403 no 335 0.0983982804437237 523 3945625 SGTC_3156 9099931 49.47 µM 1.28876505918373 0.0873447528408028 no 336 0.0987398883548785 572 18111053 SGTC_1995 st072814 61.1 µM 1.28679519503487 0.0876772300434165 no 337 0.0990828410781846 529 5769371 SGTC_2239 6685329 187.64 µM 1.28421882886558 0.0881134975978146 no 338 0.0995326994176263 562 805680 SGTC_201 4262-0159 12.803 µM 1.28348084504406 0.0882387613652171 no 339 0.0996618331021487 488 1341029 SGTC_1387 3342-1166 1.8 µM 1.28315064942585 0.0882948510107474 no 340 0.0997196509247392 478 3418228 SGTC_2920 7982904 15.77 µM 1.2820773413808 0.0884773551890331 no 341 0.0999077583021528 482 6456808 SGTC_50 0929-0078 56.389 µM 1.27920836990753 0.0889665716085887 no 342 0.100411844609067 554 1377751 SGTC_540 1187-0821 17.3 µM 1.27852337511969 0.089083674000962 no 343 0.100532474095057 543 847520 SGTC_2679 rapamycin 1 nM 1.2772301810087 0.0893050629713357 no 344 0.100760497316673 658 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2652 actinonin 100 µM 1.27482527068107 0.0897178606878769 no 345 0.101185547030445 525 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_374 0880-0231 82.3 µM 1.27394857509719 0.0898686958964694 no 346 0.101340820874441 573 6833587 SGTC_1975 st070967 30.8 µM 1.27365768984819 0.0899187842345747 no 347 0.101392378654152 634 261391 SGTC_1177 0983-0204 23.6 µM 1.27309461760969 0.0900158001505836 no 348 0.101492234338831 612 766818 SGTC_2205 7238770 200 µM 1.2725458747507 0.0901104219637524 no 349 0.101589617736025 523 279867 SGTC_2257 7960413 200 µM 1.27050379340666 0.0904631949901365 no 350 0.101952616237298 626 2974689 YIL048W NEO1 SGTC_2990 9074105 71.4286 µM 1.27000678434312 0.0905492090993679 no 351 0.10204110676247 516 6502001 SGTC_585 0kpi-0023 191 µM 1.26853741682036 0.0908038579917916 no 352 0.102303048740064 524 64601 SGTC_783 0848-0141 92.7 µM 1.26851460778793 0.0908078150977582 no 353 0.102307118723628 533 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_537 1334-0398 209 µM 1.26673461365427 0.091117018473571 no 354 0.102625099464499 595 5846986 SGTC_367 0335-0881 7.1 µM 1.25639842825783 0.0929279658676407 no 355 0.104485775609551 601 23828853 SGTC_2313 7726885 200 µM 1.2563825918579 0.0929307607465618 no 356 0.104488645041243 568 726423 SGTC_120 rhodamine 6G 52.259 µM 1.25621014779427 0.0929611984714045 no 357 0.104519894251315 679 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1842 st055362 61.2 µM 1.25202917763479 0.0937014294779124 no 358 0.105279616127535 630 676032 SGTC_2108 5365811 200 µM 1.25197614621761 0.0937108464347526 no 359 0.105289278030751 591 780283 SGTC_459 nigericin 15.3 µM 1.24992387740438 0.0940758112392651 no 360 0.105663678050822 619 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2068 5226020 147 µM 1.24890533056904 0.0942573332349718 no 361 0.105849850852548 622 1810509 SGTC_3022 9087993 49.47 µM 1.24602612981759 0.0947718518204561 no 362 0.106377401198129 548 17173644 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.24539638647319 0.094884663477318 no 363 0.106493040462195 632 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1301 naphtanilide LB 4.81 µM 1.24503669276277 0.0949491430640008 no 364 0.106559131438345 611 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 1.24434395616574 0.0950734156847656 no 365 0.106686499919511 379 4000243 SGTC_1650 st011916 45.8 µM 1.24393894926272 0.0951461268675286 no 366 0.106761016496073 549 242528 SGTC_2165 5727197 32.143 µM 1.24074310547471 0.0957213160536871 no 367 0.107350332478348 571 1361712 SGTC_1747 st037496 66.6 µM 1.23846719885394 0.0961324914496906 no 368 0.107771438604314 619 723305 SGTC_1760 st045453 10.4495 µM 1.23827045520003 0.0961680969154627 no 369 0.107807897461484 630 3323419 YIL048W NEO1 SGTC_1102 cgs 12066b 26.1 µM 1.23586226635785 0.0966047020616481 no 370 0.108254882548039 552 6438352 A 5-HT1B full agonist. SGTC_1490 4089-0339 670 nM 1.23391181002452 0.0969593860695381 no 371 0.108617884130166 557 742542 SGTC_754 3474-0146 171 µM 1.23321427786056 0.0970864617738474 no 372 0.108747914912747 556 24762078 SGTC_507 nimesulide 162 µM 1.22994310667528 0.0976840314500196 no 373 0.109359205243863 609 4495 A COX2 inhibitor. SGTC_3256 9138902 49.47 µM 1.22959034566314 0.0977486337195062 no 374 0.109425273551914 587 17228773 SGTC_350 k064-0020 19.8 µM 1.22467220860148 0.0986525726930045 no 375 0.110349374653287 647 2790705 SGTC_724 3910-0327 137 µM 1.22412007819071 0.0987544333833183 no 376 0.110453466409862 613 2885483 SGTC_189 3970-0742 2.116 µM 1.22396897506197 0.0987823233032378 no 377 0.110481965767306 579 2891807 SGTC_2813 7971799 71.43 µM 1.22368611741435 0.0988345473590479 no 378 0.110535329336918 572 2234054 SGTC_466 geldanamycin 89.2 µM 1.21993485892985 0.099529054377396 no 379 0.111244784982619 467 5288382 HSP90 inhibitor. SGTC_3243 9134147 49.47 µM 1.21771069116939 0.0999425168740352 no 380 0.111666966421999 620 24282180 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.2090119252466 0.10157162398441 no 381 0.11332913195678 645 688751 SGTC_20 0481-0013 4.944 µM 1.20733086427385 0.101888670714313 no 382 0.11365237447304 599 182045 SGTC_2457 5731572 11.68 µM 1.20487656634552 0.102352841814485 no 383 0.114125478132636 613 2865357 SGTC_2138 5575593 77.673 µM 1.20075114641189 0.103136526848145 no 384 0.11492387379553 576 762213 SGTC_551 k048-0028 34.9 µM 1.19304463348021 0.104612150124277 no 385 0.116425946660844 677 6836383 SGTC_2477 5967686 25.23 µM 1.19261257466294 0.104695330054085 no 386 0.116510569412353 617 776118 SGTC_2441 5730946 39.09 µM 1.19176398266547 0.104858840328838 no 387 0.116676901037269 636 1774275 SGTC_1962 st076595 64.5 µM 1.19025206149213 0.105150621689669 no 388 0.116973668201842 628 279619 SGTC_1335 1486-0900 202 µM 1.18918432627227 0.105357034560037 no 389 0.117183570434471 656 X1335 SGTC_549 1661-1316 519 µM 1.18852861660589 0.105483940496355 no 390 0.117312606214257 643 2857282 SGTC_2364 9055074 200 µM 1.18846275115238 0.105496694192779 no 391 0.117325573303487 587 6470630 SGTC_162 k030-0015 37.8 µM 1.18677924828786 0.105823053789813 no 392 0.117657353149951 647 1809920 YMR134W ERG29 SGTC_164 4100-3994 89.624 µM 1.18065723513336 0.107016002838634 no 393 0.118869458304021 709 4615967 SGTC_1922 5578187 25 µM 1.17659945681757 0.10781203760145 no 394 0.119677707348811 608 1350412 SGTC_1445 4239-0156 97.7 µM 1.17470981098845 0.108184190965818 no 395 0.12005541644519 746 4008346 SGTC_305 1682-2595 20.8 µM 1.17296843903901 0.108527960658925 no 396 0.120404231177075 661 226033 SGTC_2215 7188065 200 µM 1.1703781338037 0.109040773688731 no 397 0.120924415608852 592 940217 SGTC_771 0250-0039 27.3 µM 1.16745336163677 0.109621893204252 no 398 0.12151366614384 648 3005115 SGTC_1012 4112-3522 18 µM 1.1643362180794 0.110243678982556 no 399 0.122143892226721 648 3112398 SGTC_3242 9133940 49.47 µM 1.16389447435613 0.110331999123103 no 400 0.122233389584457 647 17248444 SGTC_657 3534-0529 86.7 µM 1.16271843412306 0.110567378338671 no 401 0.122471879940488 655 1049549 SGTC_2127 5253358 187.912 µM 1.16179976440198 0.11075149623413 no 402 0.122658404896125 577 20612 SGTC_1092 toremifene 6.32 µM 1.16024776457445 0.111063043742333 no 403 0.122973972520858 699 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2735 sertaconazole 140 nM 1.15975973264632 0.111161140567052 no 404 0.123073321426329 590 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3206 9114350 49.47 µM 1.15881727869312 0.111350754015783 no 405 0.123265336450901 617 17087243 SGTC_176 1486-1328 72.834 µM 1.15767613791966 0.111580651234418 no 406 0.123498112653052 671 22310231 SGTC_270 tamoxifen 5.46 µM 1.15661578911345 0.111794576110259 no 407 0.123714684270153 723 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1624 st003710 6.25 µM 1.15636163393058 0.111845895353938 no 408 0.123766633839846 704 24207033 SGTC_385 1494-0393 12.4 µM 1.15149452158606 0.112831919388473 no 409 0.124764423888613 675 3090647 SGTC_1527 coumarin 137 µM 1.15111023286191 0.112910035621614 no 410 0.124843444367301 593 323 A hepatotoxic, DNA x-linker. SGTC_3130 9127414 49.47 µM 1.14864423787886 0.113412229169688 no 411 0.125351353911691 652 1494646 SGTC_151 3013-0144 2.285 µM 1.14771843428928 0.113601177375501 no 412 0.125542409303172 683 906558 YHR107C CDC12 SGTC_1904 st060225 78 µM 1.14239124857697 0.114692769816652 no 413 0.126645713651033 659 66595 SGTC_1802 st050112 57.9 µM 1.14174663870231 0.114825361185031 no 414 0.126779674290886 679 4662563 SGTC_2916 7875993 68.79 µM 1.14067463705874 0.115046105198985 no 415 0.127002672445484 671 1299250 SGTC_349 k015-0014 24 µM 1.14030287780665 0.115122727401643 no 416 0.127080069648144 620 2196908 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.14006825771673 0.115171102927935 no 417 0.127128932501871 612 17037758 SGTC_2798 7813637 45.45 µM 1.13927231052381 0.115335324274434 no 418 0.12729479682764 668 956368 SGTC_826 1683-5028 118 µM 1.13922122957825 0.115345869073083 no 419 0.127305446524284 658 722377 SGTC_3184 9108758 49.47 µM 1.13852115478567 0.115490456744392 no 420 0.127451465247187 671 902885 SGTC_1653 st012112 65 µM 1.13696194276276 0.115812946238473 no 421 0.127777097745545 643 720429 SGTC_2981 9013952 38.96 µM 1.13560177204267 0.116094790131292 no 422 0.128061633454319 618 2996344 SGTC_1205 4161-2785 76 µM 1.13403070543407 0.11642093972818 no 423 0.12839083415089 606 3498106 SGTC_1562 morin hydrate 59.1 µM 1.13393516719026 0.116440794178396 no 424 0.128410872130296 644 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3143 9086658 49.47 µM 1.13354469573658 0.116521965667108 no 425 0.128492791315676 751 25236626 SGTC_1860 st056228 74.6 µM 1.1334414175103 0.116543441929349 no 426 0.128514464695792 645 688679 SGTC_2933 9026794 32.47 µM 1.13193716590818 0.11685656282637 no 427 0.128830426001835 693 17586027 SGTC_2498 4'-Methoxychalcone 54.63 µM 1.12782044105205 0.117716536690476 no 428 0.12969787940395 641 641818 YHR062C RPP1 SGTC_3175 9106517 49.47 µM 1.12652006342412 0.117989110996369 no 429 0.129972726541971 658 41468073 SGTC_3112 9123419 49.47 µM 1.12589180172666 0.118120961810677 no 430 0.130105659957175 716 17015854 SGTC_2591 skatole 100 µM 1.12522960200171 0.118260047828082 no 431 0.130245876117563 664 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1513 0337-0559 19 µM 1.12385599294699 0.118548924791051 no 432 0.130537061505842 613 775073 SGTC_3171 9103192 49.47 µM 1.12358095536738 0.118606826461424 no 433 0.130595419573039 662 13018434 SGTC_911 3456-4043 236 µM 1.12232560161562 0.118871360749488 no 434 0.13086201230272 717 914281 SGTC_1209 2323-2347 50.3 µM 1.12159630106804 0.119025233757323 no 435 0.13101706254454 675 5412760 SGTC_314 1671-0008 2.74 µM 1.12114972690809 0.119119524540552 no 436 0.131112067421713 724 3913060 SGTC_912 3474-0017 2.18 µM 1.12019123533949 0.119322080865945 no 437 0.131316139055648 694 3360550 SGTC_1414 3917-0015 5.4 µM 1.11878995158546 0.119618648928184 no 438 0.131614879750464 663 6618702 SGTC_318 1488-0629 67.2 µM 1.11778782118121 0.1198310586767 no 439 0.131828812107773 649 3662576 SGTC_2895 9054447 58.44 µM 1.11101281872907 0.12127405324102 no 440 0.133281415837135 671 2697450 SGTC_2430 5571206 200 µM 1.11064561255848 0.121352611383859 no 441 0.133360460587943 785 1731771 SGTC_29 0299-0004 12.984 µM 1.10775305564678 0.12197268083899 no 442 0.133984239563749 590 16871 A napthoquinone isolated from Swertia calycina. SGTC_2667 digitoxin 100 µM 1.10602116204841 0.122345005409808 no 443 0.134358679952042 614 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2980 9014342 25.29 µM 1.10576336993814 0.122400494001965 no 444 0.13441447672868 657 2996599 SGTC_22 0964-0034 14.468 µM 1.10133438803525 0.123356571648465 no 445 0.135375574937869 730 138402 SGTC_3259 9138485 49.47 µM 1.1006912364165 0.123495841685568 no 446 0.135515530835988 770 17646153 SGTC_3079 9117512 49.47 µM 1.09890207724824 0.12388385094015 no 447 0.135905390251708 756 7185044 SGTC_3163 9099914 49.47 µM 1.09580967209458 0.124556501330014 no 448 0.136581037436845 670 16268368 SGTC_2307 7538926 6.34 µM 1.09284981249416 0.125202708336764 no 449 0.137229873353835 720 96582 SGTC_1323 1348-1351 11.2 µM 1.08576719876929 0.126758501572963 no 450 0.138791000915853 692 6989654 SGTC_2414 st077232 92.9 µM 1.0848487757031 0.126961227480529 no 451 0.138994319250213 668 729801 SGTC_2452 5863136 48.41 µM 1.08466281133456 0.127002303336559 no 452 0.139035512277015 699 2184096 SGTC_3337 9144342 33.5465 µM 1.0827049199449 0.127435324218473 no 453 0.139469709770988 740 17682949 SGTC_3328 9140624 29.0385 µM 1.08100439438761 0.1278122565746 no 454 0.139847579449876 758 4904392 SGTC_2975 9084847 53.72 µM 1.0787629363745 0.128310272779073 no 455 0.140346710640377 745 27211724 SGTC_1367 1812-0510 76.9 µM 1.07856103135984 0.128355198910592 no 456 0.140391730467333 709 1142582 YDR527W RBA50 SGTC_1804 st050076 49.1 µM 1.07639817976058 0.128837142817617 no 457 0.140874608046773 734 3895976 SGTC_3204 9114183 49.47 µM 1.07555730242662 0.129024852284613 no 458 0.141062645885755 692 17027248 SGTC_1664 st014217 9.02 µM 1.07395681045117 0.129382654701982 no 459 0.141421019645629 796 3982782 SGTC_1745 st081495 74 µM 1.07141770015893 0.129951702155558 no 460 0.141990828837352 795 13842402 YBL026W LSM2 SGTC_371 0195-0006 7.36 µM 1.07130962005957 0.129975962687574 no 461 0.142015117848546 653 3928593 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.06782263489441 0.13076036221811 no 462 0.142800262901504 708 6708514 SGTC_1127 asiatic acid 681.4 nM 1.06438053749965 0.131537867503122 no 463 0.143578173426022 716 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2838 9002687 71.43 µM 1.06259914066208 0.131941502281631 no 464 0.143981888449229 683 6457060 SGTC_654 1124-0271 80.9 µM 1.06094561888793 0.13231692648582 no 465 0.144357307882231 752 5403748 SGTC_397 arbidol 50 µM 1.05866868694623 0.132835096988716 no 466 0.144875346643869 796 131410 A RNA synthesis inhibitor. SGTC_1815 st051655 58.2 µM 1.05810482854227 0.132963632072565 no 467 0.145003826658884 724 5984156 SGTC_1168 k815-0004 80.5 µM 1.05727213120341 0.133153607238926 no 468 0.145193704181679 742 642433 SGTC_221 trifluoperazine 10.304 µM 1.05421658520312 0.133852312599713 no 469 0.145891884228037 872 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3221 9128209 49.47 µM 1.05335029272039 0.134050863579554 no 470 0.146090238422506 715 16460723 SGTC_131 0141-0277 33.849 µM 1.0527366337759 0.134191634285701 no 471 0.146230856916869 746 1547771 SGTC_2749 bexarotene 57.39 µM 1.05265193360108 0.134211072111119 no 472 0.146250272898164 718 82146 An retinoic acid receptor inhibitor. SGTC_2142 5622915 118.518 µM 1.05255428687345 0.13423348343805 no 473 0.146272658790601 709 5322196 SGTC_1953 st076800 12.1 µM 1.05189076872087 0.134385838460946 no 474 0.146424833848823 752 297591 SGTC_2816 7982706 58.44 µM 1.05042878097581 0.134721954558843 no 475 0.14676050947587 703 2981853 SGTC_1408 3909-7976 48.8 µM 1.04961619402065 0.134909020359898 no 476 0.146947304294466 809 24152374 SGTC_406 estrone 100 µM 1.04826408603755 0.13522068415523 no 477 0.147258475695262 755 5870 A steroid. SGTC_545 4218-0007 221 µM 1.04723476411902 0.135458275745361 no 478 0.14749565764693 719 2840508 SGTC_1201 1889-3372 45.9 µM 1.04498599484097 0.135978339085097 no 479 0.148014721227543 733 5392199 SGTC_2991 9074669 71.4286 µM 1.04491377719084 0.135995063178764 no 480 0.148031410828233 793 17333109 SGTC_258 haloperidol 50.781 µM 1.0420040345596 0.13667007010706 no 481 0.14870490420879 736 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_180 1486-1293 102.781 µM 1.04155027577753 0.136775539940567 no 482 0.148810116211379 772 4140536 SGTC_2949 9072542 2.23 µM 1.03908339609601 0.137349904745056 no 483 0.149382976161821 765 16457352 SGTC_1484 3473-2379 286 µM 1.03743200962669 0.137735316939175 no 484 0.149767283443528 892 671917 SGTC_1438 4092-1045 4 µM 1.03406804985518 0.138522702617182 no 485 0.150552175736177 786 1351342 SGTC_1256 0570-0116 285 µM 1.03267662757467 0.138849281005737 no 486 0.150877627416614 726 410638 SGTC_3083 9117465 49.47 µM 1.03151528145873 0.139122259729459 no 487 0.15114962290977 754 16420915 SGTC_857 0438-0306 1.35 µM 1.03066987499005 0.139321205253604 no 488 0.151347828149071 765 4686136 SGTC_1310 1188-0297 994 nM 1.02878739042277 0.139764896584056 no 489 0.151789796691621 775 1588352 SGTC_2552 juarezic acid 87.02 µM 1.02448432488725 0.140782709873542 no 490 0.152803285455369 926 1549512 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.02446426120079 0.140787467329522 no 491 0.15280802148529 798 688669 SGTC_1248 0469-0687 58.6 µM 1.02411206409178 0.140870997276074 no 492 0.152891173408489 792 4017482 SGTC_2425 5628681 7.85 µM 1.02400079055497 0.140897394805777 no 493 0.152917450753174 874 5714958 SGTC_3146 9095609 49.47 µM 1.02301985472256 0.141130248348823 no 494 0.153149229172339 776 17173999 SGTC_226 1,3-diallylurea 8.28947 mM 1.01793944166674 0.142340405671363 no 495 0.154353368093904 742 74537 YKL182W FAS1 SGTC_1713 st033146 12.748 µM 1.01753585549758 0.142436840229285 no 496 0.154449292124055 793 674619 SGTC_2179 6298986 200 µM 1.01742094360657 0.142464305835419 no 497 0.15447661149447 764 738374 SGTC_2116 5511452 16.8835 µM 1.01721843137963 0.142512717909272 no 498 0.15452476490939 799 870744 SGTC_3109 9122853 49.47 µM 1.01415255238535 0.143246998707436 no 499 0.155254982501895 834 1234709 SGTC_2415 st077333 57.7 µM 1.0113504039982 0.143920346979787 no 500 0.15592437486489 884 2766255 SGTC_3029 9088683 49.47 µM 1.00925568834317 0.144425093538962 no 501 0.156426012715217 778 25236615 SGTC_1142 3253-1408 9.78 µM 1.00923871885479 0.144429187403428 no 502 0.156430080865571 788 256655 SGTC_1499 4480-0877 67.3 µM 1.0086936926139 0.144560715784652 no 503 0.156560778824858 752 2861909 SGTC_1969 st069479 40.1 µM 1.00624599530846 0.145152400769854 no 504 0.157148625826965 752 3895485 SGTC_605 1315-0399 119 µM 1.00554672821473 0.145321734377079 no 505 0.157316830326676 838 24020461 SGTC_2936 9038235 15.59 µM 1.00214759669544 0.146146756232783 no 506 0.158136156407905 759 4749415 SGTC_2622 2-methoxyxanthone 59.94 µM 0.995119570959114 0.147862526776988 no 507 0.159839056571446 859 71034 A hepatoprotective. SGTC_1813 st051246 8.6015 µM 0.994499915743793 0.148014449164458 no 508 0.159989773204715 794 5291959 SGTC_898 1000-0849 28.3 µM 0.993410363792052 0.148281830557523 no 509 0.160255006525269 832 6751807 SGTC_2251 lansoprazole 556 µM 0.992350500133303 0.148542236147302 no 510 0.160513288327372 657 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_887 0885-0007 9.62 µM 0.992317857442846 0.148550261217547 no 511 0.160521247450711 832 5719458 SGTC_1724 st037281 8.293 µM 0.991674538189267 0.148708477744897 no 512 0.160678157757168 778 574124 YDL195W SEC31 SGTC_1101 ebselen 5.29 µM 0.990755396325701 0.148934724843876 no 513 0.160902516968239 877 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2210 7115885 190.385 µM 0.990263296975194 0.149055949753401 no 514 0.16102272065719 835 2927039 SGTC_2602 kawain 100 µM 0.989737734614365 0.149185490785497 no 515 0.16115116296136 866 5369129 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.988892184887745 0.149394060297833 no 516 0.161357947298634 861 676296 Flavone; oxidizing agent. SGTC_971 1315-0384 26.7 µM 0.985734853535424 0.150174590628912 no 517 0.162131620763641 781 6769120 SGTC_411 enrofloxacin 100 µM 0.984592951615488 0.150457550653937 no 518 0.162412026611339 840 71188 A bacterial gyrase inhibitor. SGTC_3140 9094243 49.47 µM 0.981927808069068 0.151119346665502 no 519 0.163067707465924 882 19291112 SGTC_757 1066-0008 322 µM 0.981525496243173 0.151219414854416 no 520 0.163166833819094 846 6842497 SGTC_541 4513-1321 94 µM 0.981044933777586 0.151339004313093 no 521 0.163285291805312 776 747515 SGTC_1341 1486-1360 280 µM 0.980791767136773 0.151402030905515 no 522 0.163347719499424 817 3976547 SGTC_931 2812-0076 566 µM 0.979777365679521 0.151654744244718 no 523 0.163598013585245 829 3450959 SGTC_298 1391-0729 10 µM 0.979280569357806 0.151778611128567 no 524 0.163720684231824 803 3237558 SGTC_2790 5423970 71.43 µM 0.979225504583775 0.151792344639063 no 525 0.163734284689075 863 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_668 1682-0499 62.6 µM 0.978144932893962 0.152062013291008 no 526 0.164001323660606 868 682214 SGTC_382 3229-0966 23.2 µM 0.975184260476103 0.152802511214421 no 527 0.164734434037141 865 5722370 SGTC_773 4358-1457 44.6 µM 0.974740504777862 0.152913705311024 no 528 0.164844497796063 886 1186886 SGTC_309 k408-0051 1.48 µM 0.972621408230464 0.153445437663302 no 529 0.165370749316663 877 3640463 SGTC_3241 9133421 49.47 µM 0.969934704025358 0.154121355129438 no 530 0.166039520141366 829 17018221 SGTC_2367 9070478 135.38 µM 0.969078956599868 0.154337055867621 no 531 0.16625289808719 816 572802 SGTC_2034 5197015 53.07 µM 0.968860498882332 0.154392152553858 no 532 0.166307398200645 829 780676 SGTC_569 4130-2812 160 µM 0.967489200723262 0.154738301291692 no 533 0.166649768645699 731 743552 SGTC_2850 9015429 58.44 µM 0.966450383165762 0.155000864990432 no 534 0.166909431624805 781 6457570 SGTC_1279 0874-0590 65.2 µM 0.964979923086786 0.15537303009853 no 535 0.167277433926198 862 3523074 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.96485263075766 0.155405274774748 no 536 0.167309315110485 818 279621 SGTC_1895 st058434 18.3 µM 0.964548441133087 0.155482347543746 no 537 0.167385517222306 868 5393175 SGTC_556 4058-0063 51.5 µM 0.963178544121295 0.155829751910221 no 538 0.167728965280616 873 6615692 SGTC_2897 9048598 12.99 µM 0.962619080617113 0.155971778306431 no 539 0.167869359272903 799 6467404 SGTC_835 0312-0010 67.2 µM 0.96233930810603 0.156042833843413 no 540 0.167939594864074 800 1626196 SGTC_1390 3413-2614 145 µM 0.962079216535716 0.156108910023526 no 541 0.168004906610026 856 3421432 SGTC_2166 5933061 31.504 µM 0.961329371616127 0.156299511071398 no 542 0.168193292092395 820 2877375 SGTC_1114 scopoletin 1.73284 µM 0.960709460009137 0.15645720042302 no 543 0.168349136668765 843 5280460 A coumarin with genotoxic properties. SGTC_2700 st077718 96.8 µM 0.960566043240449 0.15649369682693 no 544 0.168385204590641 778 904970 SGTC_135 0933-0004 26.348 µM 0.959103204754521 0.15686627712356 no 545 0.168753378056882 796 21230617 YGL099W LSG1 SGTC_1476 4112-3294 3.34 µM 0.954833728119789 0.157957034155418 no 546 0.169830893991836 866 704369 SGTC_467 ro 31-8220 72.8 µM 0.954086376132276 0.158148477006811 no 547 0.170019960858585 855 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_577 r071-0003 38.6 µM 0.953198016390841 0.15837623863904 no 548 0.170244875626182 989 4568517 YMR134W ERG29 SGTC_574 1315-0397 40 µM 0.951047103686921 0.158928590061262 no 549 0.170790232453041 963 6794277 SGTC_2930 9013230 14.89 µM 0.951025688638069 0.158934095755726 no 550 0.170795667783092 887 2995857 SGTC_930 2810-3379 265 µM 0.949309561537253 0.159375709187386 no 551 0.171231595979377 925 1015764 SGTC_3103 9120822 49.47 µM 0.947803033638636 0.15976404775006 no 552 0.171614867937144 901 17141819 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.947131535501374 0.159937339509105 no 553 0.17178587854335 888 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1037 k284-1091 78.7 µM 0.945000865489042 0.160488009495497 no 554 0.172329217083455 790 3334711 SGTC_2046 4110841 106 µM 0.944379859413744 0.160648740875785 no 555 0.172487784903669 880 44119630 YMR134W ERG29 SGTC_1282 0886-0010 32.4 µM 0.944302188461744 0.160668851389783 no 556 0.172507623965646 948 2836211 YNL267W PIK1 SGTC_1396 3511-0007 98.6 µM 0.942098216485877 0.16124018763265 no 557 0.173071178771544 775 X1396 SGTC_2181 6316240 54.2555 µM 0.941270482643064 0.16145510322651 no 558 0.173283132589961 805 12779990 SGTC_1485 3909-9022 254 µM 0.940745651667257 0.16159146882482 no 559 0.173417609113034 921 714516 SGTC_1697 st025554 27.742 µM 0.940011774270729 0.161782276323048 no 560 0.173605760592881 838 1269519 SGTC_830 4076-0286 57.8 µM 0.939352213085786 0.161953886889795 no 561 0.173774969668247 979 6866659 SGTC_967 1306-0166 352 µM 0.938570223348924 0.162157505606107 no 562 0.173975723410771 871 4437607 SGTC_2540 epiandrosterone 100 µM 0.937406479548944 0.16246083600758 no 563 0.17427475460224 1046 441302 A steroid. SGTC_1026 k007-1105 30.6 µM 0.93701397983542 0.162563224471582 no 564 0.174375683447485 890 7066794 SGTC_291 SEC14.278 35.5 µM 0.936198620584238 0.162776055309448 no 565 0.174585466643545 888 1068044 SGTC_1293 1000-1278 195 µM 0.935570199701004 0.162940213776176 no 566 0.174747261916429 888 678847 SGTC_244 nsc-207895 1.295 µM 0.934205858875566 0.163296982394125 no 567 0.175098857049184 764 42640 SGTC_958 1222-0007 33 µM 0.928956793448994 0.16467431651451 no 568 0.176455739127434 922 7312461 SGTC_2269 7935389 174.42 µM 0.928785549540343 0.164719376662222 no 569 0.176500117380188 832 97605 SGTC_167 3672-0051 66.205 µM 0.928077694100702 0.164905722459622 no 570 0.176683634639132 821 3237971 SGTC_2109 5483026 200 µM 0.927801566831476 0.164978451077568 no 571 0.176755255570392 880 759335 SGTC_170 4197-0004 226 µM 0.926124786045099 0.165420540989956 no 572 0.177190567180898 808 218692 SGTC_3012 9080433 71.4286 µM 0.926090774037011 0.165429516314376 no 573 0.177199404091163 931 17688859 SGTC_1090 efavirenz 20.7 µM 0.925892928889133 0.16548173130936 no 574 0.177250813214593 886 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_380 3970-0968 6 µM 0.925802753080225 0.165505533910274 no 575 0.177274248095549 845 2891601 SGTC_1938 st074717 56.4 µM 0.925447859346973 0.165599232358206 no 576 0.177366496848437 819 17250979 SGTC_2395 5646831 180.19 µM 0.924702215497001 0.16579620773019 no 577 0.177560413342675 862 6808628 SGTC_2678 equilin 100 µM 0.923901831244626 0.166007812253848 no 578 0.177768714785628 918 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2872 9044037 25.97 µM 0.923750564085584 0.166047823663295 no 579 0.177808099649767 856 6465195 SGTC_515 4092-1064 102 µM 0.923364702762199 0.166149915378541 no 580 0.177908589844092 952 717353 SGTC_2047 4141938 200 µM 0.923358780259275 0.166151482678343 no 581 0.177910132525636 833 3807862 SGTC_1658 st012944 20 µM 0.922760463609589 0.166309867245799 no 582 0.178066024307433 847 24207260 SGTC_2528 xanthyletin 44.79 µM 0.922706880212379 0.166324056435544 no 583 0.178079989695935 878 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3345 9148410 3.559 µM 0.918431079670509 0.167458832712123 no 584 0.179196612831445 886 4903596 SGTC_1466 k213-0079 57.5 µM 0.915174709189868 0.168326395451348 no 585 0.180049959714575 910 3657981 SGTC_1420 4'-methoxyflavone 42 µM 0.912806941685168 0.168959028336552 no 586 0.180672043397961 910 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1742 st038235 28.8875 µM 0.911119786564939 0.169410742178691 no 587 0.181116131018599 852 564103 YBR002C RER2 SGTC_1892 st058411 7.36 µM 0.910575884062511 0.169556530050626 no 588 0.181259440942128 951 3934738 SGTC_2607 solasodine 47.35 µM 0.909654830564982 0.169803593151516 no 589 0.181502286238422 890 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1973 st070275 50.2 µM 0.908375265496315 0.170147206205227 no 590 0.181839994633022 890 17118334 SGTC_1609 st001574 46.4 µM 0.907338491454819 0.170425946957091 no 591 0.182113912605534 919 3960012 SGTC_12 0849-0099 9.267 µM 0.905340227799969 0.170964012482774 no 592 0.182642585466119 886 6071388 SGTC_2153 5569715 200 µM 0.905050118667266 0.171042219409349 no 593 0.182719418101304 899 2054701 SGTC_2658 polymyxin b sulfate 77.05 µM 0.904577107717709 0.171169781634477 no 594 0.182844733802789 917 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_914 3820-6779 408 µM 0.903395700427033 0.171488650783307 no 595 0.18315796055395 904 2893481 SGTC_395 anisomycin 6.25 µM 0.901563170523671 0.17198401253864 no 596 0.183644481340326 857 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1243 0416-0003 5.65 µM 0.900768884482567 0.172199004092311 no 597 0.183855607318221 882 2141977 SGTC_1596 piperlongumine 63 µM 0.900297872536036 0.172326575140556 no 598 0.183980876482944 959 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3188 9110789 49.47 µM 0.898626976962419 0.172779614381606 no 599 0.184425692232778 902 849217 SGTC_3356 9151811 4.48 µM 0.89822190332066 0.172889558481619 no 600 0.184533629166574 894 1859254 YPR165W RHO1 SGTC_1115 galangin 695.678 nM 0.897764452558212 0.173013772240211 no 601 0.184655569864887 996 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1686 st019653 115.5 µM 0.896920233705496 0.173243156196329 no 602 0.184880741196389 939 97252 SGTC_178 4092-0806 87.505 µM 0.895115207376317 0.173734251913967 no 603 0.185362752719065 936 2169044 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.894346977712212 0.173943533491839 no 604 0.185568136088636 900 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2818 7996756 12.99 µM 0.893901861390543 0.17406486565884 no 605 0.185687200887281 857 2241621 SGTC_1928 4'-methoxychalcone 40.3 µM 0.893457247484934 0.174186114571787 no 606 0.185806178597899 959 641818 SGTC_1307 1187-1599 12.2 µM 0.890142199486762 0.175091839771017 no 607 0.186694768104272 905 1538471 SGTC_2137 5261020 140 µM 0.882675485299446 0.177142787599188 no 608 0.188705815513839 913 763655 SGTC_134 0269-0018 6.916 µM 0.881258732852832 0.177533645486772 no 609 0.189088898247043 873 4378915 SGTC_1930 st074634 34.3 µM 0.880242133301756 0.177814443156724 no 610 0.189364076576396 949 684253 YOR116C RPO31 SGTC_2753 fluvastatin 17.09 µM 0.879847441535002 0.17792353747778 no 611 0.189470980142246 923 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_591 4299-0174 154 µM 0.879820839336843 0.177930891945647 no 612 0.189478186770975 933 5509088 SGTC_1405 3909-7894 12 µM 0.875863033761776 0.179027205962081 no 613 0.190552248863036 954 7104060 SGTC_590 k048-0076 22.4 µM 0.874814013360391 0.17931849615694 no 614 0.190837555564544 924 6832814 SGTC_1009 4106-0057 9.87 µM 0.873737158774425 0.179617825106389 no 615 0.191130704914388 994 2928005 SGTC_1234 0326-0494 15.5 µM 0.873423523927735 0.179705063936096 no 616 0.191216136813761 962 1547813 SGTC_71 0417-1750 47.813 µM 0.872635740850422 0.179924306446956 no 617 0.191430826541816 960 6811472 SGTC_509 pifithrin 175 µM 0.872621948543992 0.179928146384889 no 618 0.191434586590285 999 4817 A p53 inhibitor. SGTC_685 1278-0033 54.9 µM 0.868977220776745 0.180944684223712 no 619 0.192429795156734 958 3590572 SGTC_2889 9059656 51.95 µM 0.868361559475732 0.181116750734107 no 620 0.192598215885143 987 3949838 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.867284901090017 0.181417904094813 no 621 0.19289296375475 1014 5106787 A p450 inhibitor. SGTC_2877 9040724 71.43 µM 0.86176653762737 0.182966368520841 no 622 0.194408001160238 960 6463895 SGTC_3192 9110362 49.47 µM 0.859264801175957 0.183671069902127 no 623 0.195097219518107 987 16649480 SGTC_1489 4065-0444 182 µM 0.858037212883619 0.184017480662214 no 624 0.195435957691818 947 2877968 SGTC_736 0958-0254 92.6 µM 0.857833013098146 0.184075142839096 no 625 0.195492338791619 992 6812352 SGTC_103 0844-0104 51.839 µM 0.857132468441723 0.184273048943557 no 626 0.195685839514663 1053 5375804 SGTC_2088 5278280 127.392 µM 0.852534717020365 0.185575212260628 no 627 0.196958689356573 987 791502 SGTC_3041 9091929 49.47 µM 0.852438356345676 0.185602564232745 no 628 0.196985419529475 1037 25236887 SGTC_3281 9140613 49.47 µM 0.852183589488077 0.185674891840257 no 629 0.197056101696864 909 16013766 SGTC_726 3448-4391 34.2 µM 0.851937314542228 0.18574482523726 no 630 0.197124442468449 1004 1356692 SGTC_195 4234-0266 16.654 µM 0.851733479343171 0.185802719600055 no 631 0.197181017147255 989 2303354 SGTC_834 0312-0008 75.7 µM 0.850177210018694 0.186245108391392 no 632 0.197613285126005 959 6385573 YIL048W NEO1 SGTC_1363 1636-0063 10.4 µM 0.849850932839169 0.186337939410857 no 633 0.19770398416565 1001 6072185 SGTC_792 4534-1957 155 µM 0.849321586492895 0.186488607788934 no 634 0.197851186195173 970 1717904 SGTC_1425 4048-4433 7.33 µM 0.849267101581036 0.18650412016534 no 635 0.197866341260818 1031 23734946 SGTC_2546 rhodinyl acetate 100 µM 0.847101969593708 0.187121200697941 no 636 0.198469143698989 999 6708682 SGTC_1337 1486-1011 40.3 µM 0.846958658987891 0.187162089916845 no 637 0.198509082393183 1022 X1337 SGTC_3070 9117005 49.47 µM 0.846674087609263 0.187243299877544 no 638 0.198588402892166 944 8779016 SGTC_3273 9137859 49.47 µM 0.846454991602252 0.187305839554318 no 639 0.198649486022471 998 2377234 SGTC_3036 9090181 49.47 µM 0.843260155804425 0.188219253396161 no 640 0.19954148069241 965 25236586 SGTC_3053 9095903 49.47 µM 0.843240957445567 0.1882247505634 no 641 0.199546848129421 1024 17174018 SGTC_2304 7443016 91.4 µM 0.84248561474209 0.188441110437151 no 642 0.199758094219706 907 939854 SGTC_3228 9131799 49.47 µM 0.841807389280932 0.188635511536235 no 643 0.199947887573191 939 17015818 SGTC_292 k038-0015 474 µM 0.840769571576837 0.188933222507033 no 644 0.200238518371139 988 46368540 SGTC_1559 coumarin 343 70.1 µM 0.840735460856224 0.188943012504313 no 645 0.200248075055019 949 108770 A hepatotoxic, DNA x-linker. SGTC_856 0433-0016 11.3 µM 0.838904522079596 0.189468962296374 no 646 0.200761444998974 981 3911780 SGTC_812 4251-0442 148 µM 0.838597210434883 0.189557327903612 no 647 0.200847688294499 998 5723007 SGTC_3223 9129970 49.47 µM 0.838520143044552 0.189579492142342 no 648 0.200869319811633 1023 17248386 SGTC_3319 9138450 16.7555 µM 0.8371817375012 0.189964665869232 no 649 0.20124521059707 936 2029690 SGTC_1347 1493-0251 600 nM 0.835953399745804 0.19031858669766 no 650 0.201590559740587 1039 3986378 SGTC_2960 9079389 5.97 µM 0.835571671650413 0.190428656413342 no 651 0.201697955480956 993 16457355 SGTC_2522 biochanin a 4.94 µM 0.834711877682583 0.190676717592383 no 652 0.201939976203741 985 5280373 A possible chelator. SGTC_975 1335-0046 28.5 µM 0.834087051354931 0.190857112081155 no 653 0.2021159656386 1006 16486740 SGTC_3110 9122132 49.47 µM 0.829637447260699 0.192144789234705 no 654 0.203371898907056 1019 918317 SGTC_1789 tunicamycin 25 nM 0.8287605453027 0.192399182664325 no 655 0.203619959033648 998 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_123 0083-0120 66.675 µM 0.828738019425495 0.192405720240433 no 656 0.203626333583815 984 16001701 SGTC_3102 9121669 49.47 µM 0.827570180873086 0.192744842402088 no 657 0.203956980725749 1000 41905072 SGTC_1121 fusaric acid 630.51 nM 0.8273763691172 0.192801157636077 no 658 0.204011885088544 974 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_743 1275-0778 158 µM 0.82550192008656 0.193346328614961 no 659 0.204543346523048 1031 2849257 YMR203W TOM40 SGTC_55 0767-0285 6.563 µM 0.825285271895889 0.193409399880202 no 660 0.204604825726894 1027 3116166 SGTC_947 3447-0010 211 µM 0.823987462104323 0.193787484886173 no 661 0.204973341023912 1027 748350 SGTC_286 k060-0067 22.9 µM 0.823017100261127 0.194070470140849 no 662 0.205249134548593 972 5985051 SGTC_3092 9117248 49.47 µM 0.822943182531152 0.194092036978463 no 663 0.20527015227146 1071 17141857 SGTC_1320 1313-0481 95.3 µM 0.821923631797765 0.194389658321544 no 664 0.205560181135718 1057 6813365 YLR208W SEC13 SGTC_731 3966-0296 387 µM 0.82156167699019 0.194495384863728 no 665 0.205663203936761 1014 660956 SGTC_2704 st078022 71.1 µM 0.817080871253167 0.195807119199242 no 666 0.206941106867408 1029 54697681 SGTC_2119 5528445 120.635 µM 0.815931513898734 0.196144451295404 no 667 0.20726965341002 1009 791935 SGTC_1913 st060213 96.1 µM 0.815360621554934 0.196312136991378 no 668 0.207432958939533 1054 688959 SGTC_1581 himbacine 57.9 µM 0.813508285099956 0.196856813777911 no 669 0.20796334902659 997 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2256 7954252 200 µM 0.813382315309367 0.196893888207492 no 670 0.207999447730406 895 2972920 SGTC_581 0958-0271 211 µM 0.812834974764195 0.197055026217171 no 671 0.208156340065414 1086 4591145 SGTC_1706 st031321 9.9705 µM 0.812794878302284 0.197066833822141 no 672 0.208167836253541 1054 6103185 SGTC_1970 st070122 35.8 µM 0.810512426858324 0.197739675786805 no 673 0.208822862893116 1021 102928 SGTC_1174 0739-0097 51.1 µM 0.810340270133267 0.197790481965734 no 674 0.208872318294797 1019 728447 SGTC_101 0490-5701 117.494 µM 0.809775040805443 0.19795734555322 no 675 0.209034740036846 962 4661669 SGTC_937 3122-0005 46.7 µM 0.809210089665825 0.198124211950998 no 676 0.209197156143949 1057 759535 SGTC_2079 5212404 121 µM 0.807191960197621 0.198720988545455 no 677 0.209777948507425 1051 758462 SGTC_480 am 92016 50 µM 0.806510108313188 0.198922862166777 no 678 0.209974390978485 988 2129 K+ channel blocker. SGTC_568 1193-0097 7.48 µM 0.803781078414592 0.199732073486391 no 679 0.210761709677653 999 3646150 SGTC_2529 gangaleoidin 93.61 µM 0.803490492018243 0.199818354605822 no 680 0.210845645053337 1046 4565183 SGTC_694 1315-0438 43.2 µM 0.802562845754036 0.200093941973888 no 681 0.211113725207341 964 6793154 SGTC_3158 9100007 49.47 µM 0.802325195343017 0.200164580472297 no 682 0.211182435842665 1047 19297233 SGTC_837 0091-0265 12.5 µM 0.802266414442113 0.20018205464346 no 683 0.21119943288205 1028 759367 SGTC_697 0508-1955 564 µM 0.801644280520886 0.200367056535291 no 684 0.211379377774034 1062 6243113 SGTC_1035 k081-0041 55.2 µM 0.801237062789182 0.200488205113832 no 685 0.211497209304801 1061 731709 SGTC_3167 9103034 49.47 µM 0.799710599710371 0.200942724149274 no 686 0.211939245107207 1027 5127859 SGTC_748 act1.228 77.9 µM 0.798562654187292 0.201284942873086 no 687 0.212272024868834 1027 4421505 YNR035C ARC35 SGTC_3132 9126706 49.47 µM 0.7978415261068 0.201500099881396 no 688 0.212481229932108 997 850858 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.792035796306599 0.203237322855033 no 689 0.214169902130684 1036 4330530 SGTC_1117 retinoic acid 1.10837 µM 0.791000558815401 0.203548028860695 no 690 0.214471832696639 1081 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1451 4152-0210 104 µM 0.790439136861664 0.203716646942176 no 691 0.214635676784439 1062 659563 SGTC_2455 5377712 9.75 µM 0.788089867078796 0.204423132010678 no 692 0.215322070904098 981 2243908 SGTC_2945 9067681 61.76 µM 0.787193488103577 0.204693079847953 no 693 0.21558430432718 1093 16456930 SGTC_2466 5983409 37.09 µM 0.784690028207429 0.205448128332541 no 694 0.216317665384856 1008 2879657 SGTC_2673 kobusone 100 µM 0.784497961595274 0.205506124236897 no 695 0.216373988771823 1094 6710676 An epoxy ketone and protein crosslinker. SGTC_526 4469-0568 170 µM 0.784152537052111 0.205610452137779 no 696 0.216475305611883 1046 2901964 SGTC_3191 9110352 49.47 µM 0.783628703429586 0.205768724562205 no 697 0.216629004179287 1044 17122424 SGTC_1371 2421-0008 32.7 µM 0.783588113790267 0.205780991436414 no 698 0.216640916262042 1012 2827552 SGTC_1594 piperine 70.1 µM 0.782846142163541 0.206005304244239 no 699 0.216858733842735 1044 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_182 3448-4371 550.524 µM 0.782802618062345 0.206018466948577 no 700 0.21687151496548 1102 3491403 SGTC_935 2996-0153 430 µM 0.781996056579009 0.206262480224699 no 701 0.217108445554329 1063 23738523 SGTC_2796 7949634 45.45 µM 0.781924169977477 0.206284236766634 no 702 0.217129569780805 1011 2971588 SGTC_2662 daunorubicin 22.37 µM 0.780325061341259 0.206768559939465 no 703 0.217599782526775 1038 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_760 0568-0725 82.9 µM 0.779989135750418 0.20687038746152 no 704 0.217698635002578 1107 3916171 SGTC_555 4296-0685 37 µM 0.779803634610465 0.206926630255788 no 705 0.217753233333208 1084 2908540 YHR072W ERG7 SGTC_3164 9100705 49.47 µM 0.779034770573739 0.207159841526846 no 706 0.217979616379356 1045 17174235 SGTC_997 3996-0078 137 µM 0.777461761162686 0.20763744969712 no 707 0.218443193208707 1102 735687 SGTC_3311 9131146 2.8755 µM 0.777242134828972 0.207704185909423 no 708 0.218507963760968 1033 4900406 YPR165W RHO1 SGTC_1458 k015-0034 6.33 µM 0.77684003727912 0.207826401117309 no 709 0.218626576009821 1067 3598957 SGTC_2571 chrysanthemic acid 100 µM 0.776831833780648 0.207828894964877 no 710 0.218628996294423 1015 2743 An insecticide. SGTC_48 0382-0018 55 µM 0.774319242828307 0.208593549083739 no 711 0.219371013481308 1139 762596 SGTC_2773 thioridazine 9.09 µM 0.773382281194543 0.208879117641911 no 712 0.219648086558166 1129 5452 An antipsychotic. SGTC_889 0919-1524 82.7 µM 0.772141616495377 0.209257603465607 no 713 0.220015278050282 1028 3905452 SGTC_901 1112-0062 60.1 µM 0.771756558284991 0.209375154045 no 714 0.22012931280709 1113 1908457 SGTC_327 1273-0057 3.96 µM 0.76962251238029 0.210027339735603 no 715 0.220761923461224 1037 3108138 SGTC_1157 4092-0394 27.6 µM 0.766973979181182 0.210838415597158 no 716 0.221548493292371 1140 3659885 SGTC_1694 st024011 44.9 µM 0.765214458895974 0.211378257839814 no 717 0.222071925604339 1150 2787533 SGTC_331 k048-0133 24.5 µM 0.764847885715959 0.211490828771968 no 718 0.222181064712607 1089 6813582 SGTC_2069 5228469 200 µM 0.763650345712245 0.211858825823044 no 719 0.222537819195164 1061 2835210 SGTC_871 0574-0004 149 µM 0.762374187523544 0.212251393795129 no 720 0.222918353757622 1048 9551173 SGTC_1236 0330-0013 258 µM 0.761466482782329 0.212530877797031 no 721 0.223189245510357 1059 4617066 SGTC_1675 st018485 24.5 µM 0.759825010814495 0.213036835605832 no 722 0.223679595354041 1075 3323024 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.757790006284468 0.213665068220329 no 723 0.224288353039934 1171 23665772 A membrane-active detergent. SGTC_2911 7942208 15.64 µM 0.756828947069389 0.213962134621407 no 724 0.224576174009649 1076 1243384 SGTC_485 niflumic acid 177 µM 0.756629922172162 0.214023683875963 no 725 0.224635804777267 1069 4488 A COX2 inhibitor. SGTC_2868 9035608 32.47 µM 0.755833476071473 0.214270091168601 no 726 0.22487452153164 1128 6462614 SGTC_3122 9126309 49.47 µM 0.755712742309694 0.214307458603102 no 727 0.22491072130202 1178 17591206 SGTC_353 1988-1175 58.3 µM 0.753976934937933 0.214845114662152 no 728 0.225431535824621 1013 2788357 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.753689728741939 0.214934150572675 no 729 0.225517775429884 1059 2374 Ca(2+)-ATPase inhibitor. SGTC_2842 9000675 19.48 µM 0.752129588221151 0.215418179186017 no 730 0.225986565998333 1100 2989072 SGTC_2944 9067346 25.62 µM 0.75130532508485 0.215674159279577 no 731 0.226234462594002 1030 6473075 SGTC_1181 1222-0449 220 µM 0.750810163344794 0.215828019622305 no 732 0.226383456000244 1133 658318 SGTC_1886 st057356 49.9 µM 0.750798950449508 0.215831504513031 no 733 0.226386830584746 1078 24207747 SGTC_2811 7967822 32.47 µM 0.748883045529329 0.21642743325099 no 734 0.226963850033078 1103 2232244 SGTC_1952 st077036 64.1 µM 0.748195751622909 0.216641443031244 no 735 0.227171046582039 1141 2937007 SGTC_1393 3470-5649 58.2 µM 0.747868092988403 0.216743512546636 no 736 0.227269862420914 1021 4108395 SGTC_2764 methyldopa 94.69 µM 0.74737905286631 0.216895906008267 no 737 0.227417393003577 1108 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1368 1852-0141 284 µM 0.74723989582071 0.216939281096786 no 738 0.22745938289299 1090 2838987 SGTC_1265 0819-1001 68.8 µM 0.744786301357714 0.217704886769811 no 739 0.228200458712091 1121 3106768 SGTC_2539 epi(13)torulosol 80 µM 0.744000503503706 0.217950411842815 no 740 0.2284380852476 1121 6708597 SGTC_2995 9067767 71.4286 µM 0.743600804772909 0.218075360235887 no 741 0.22855900811074 1086 11673567 SGTC_169 k015-0017 16.025 µM 0.742534691389582 0.218408836007976 no 742 0.228881720525191 1118 1840002 SGTC_192 3455-0609 60.9 µM 0.742123266761444 0.218537606399412 no 743 0.229006327071888 1162 3769639 SGTC_2849 9019321 12.99 µM 0.741470543207428 0.218741989782687 no 744 0.229204092936045 1078 16489627 SGTC_1571 st070080 73.4 µM 0.740251065186516 0.219124132168643 no 745 0.229573833753829 1127 4315245 SGTC_1991 st073000 8.92 µM 0.740167075220967 0.219150465850855 no 746 0.229599311466748 1139 4301969 YIL048W NEO1 SGTC_2763 lisinopril 49.32 µM 0.739251702792702 0.219437583878441 no 747 0.229877085365459 1088 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3091 9116372 49.47 µM 0.73872195559542 0.219603844401949 no 748 0.23003792544895 1117 17169793 SGTC_2416 tofa 880 nM 0.738589413857908 0.219645453779313 no 749 0.230078177177653 1064 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1638 st008370 60.6 µM 0.738528598137205 0.219664547425869 no 750 0.230096647681698 1161 24207134 SGTC_868 0527-0199 213 µM 0.736647737332299 0.220255531088062 no 751 0.230668298343091 1084 2849450 SGTC_1317 1273-0028 910 nM 0.735207978999225 0.220708531700111 no 752 0.23110642019624 1116 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1464 k208-0027 110 µM 0.734551272160519 0.220915332763114 no 753 0.231306411749783 1123 X1464 SGTC_2912 7964298 10.93 µM 0.732448920619298 0.221578121804647 no 754 0.231947304396307 1174 2975850 SGTC_274 sirtinol 40.1 µM 0.73226709276645 0.221635498348325 no 755 0.232002780242215 1156 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.731927604937515 0.221742647882092 no 756 0.232106378063222 1077 6857784 SGTC_3249 9135183 49.47 µM 0.729678230575869 0.222453345200203 no 757 0.232793445405635 1193 4902779 SGTC_2618 avocadyne 43.43 µM 0.729023889354293 0.22266033014059 no 758 0.232993524735061 1106 3015189 SGTC_2427 5545055 42.75 µM 0.728029111215824 0.222975214240387 no 759 0.233297883073629 1170 5372858 SGTC_224 benfluorex 43.875 µM 0.726969514551344 0.223310894593803 no 760 0.233622315549932 1159 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.726863196450134 0.223344592050329 no 761 0.233654882348731 1141 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3333 9141820 12.094 µM 0.726763155408741 0.223376302638849 no 762 0.233685528690063 1081 1939433 SGTC_2133 5320837 200 µM 0.726442002915158 0.223478117516245 no 763 0.233783924859908 1112 2841355 SGTC_2617 dihydrotanshinone i 20.83 µM 0.726356644972995 0.223505182958829 no 764 0.233810081078756 1182 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1001 4048-4355 44.4 µM 0.725693473038745 0.223715526159675 no 765 0.234013351974091 1151 21824233 SGTC_384 k007-0144 5.16 µM 0.724988798608869 0.223939156296862 no 766 0.23422945115429 1146 6824886 SGTC_563 tetrahydrosecaminediol 614 µM 0.724038130732973 0.224241054229129 no 767 0.234521162955728 1195 334274 A psychoactive constituent of the cannabis plant. SGTC_970 1315-0089 19.5 µM 0.720240130037148 0.225449465827412 no 768 0.235688579835504 1123 6811083 YLR033W RSC58 SGTC_452 diindolylmethane 8 µM 0.716932113670852 0.226504975880607 no 769 0.236707992827568 1094 3071 Inhibits expression of several cancer promoting factors. SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.716309753075573 0.22670386785348 no 770 0.236900052926401 1133 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3220 9131269 49.47 µM 0.715902837290722 0.226833961942207 no 771 0.237025673192792 1192 17722206 SGTC_1604 st002052 72.4 µM 0.715322635292221 0.227019529774524 no 772 0.237204852493059 1194 6254834 YHR062C RPP1 SGTC_1274 0865-0114 173 µM 0.713994336543259 0.227444685894975 no 773 0.237615340749845 1179 870624 SGTC_2178 5812956 200 µM 0.712878087381223 0.227802316640941 no 774 0.237960599870172 1172 5403383 SGTC_216 k038-0035 28.382 µM 0.712634506536879 0.227880398605753 no 775 0.238035976674532 1120 4444231 YPR107C YTH1 SGTC_2726 cimetidine 79.27 µM 0.712185047254715 0.228024516221528 no 776 0.238175097511003 1171 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3004 9076122 71.4286 µM 0.711154801905325 0.228355054296825 no 777 0.238494156709357 1159 44782551 SGTC_966 1300-0360 30.2 µM 0.710536018377616 0.228553710655017 no 778 0.238685901708334 1175 70588 SGTC_2824 7998404 51.95 µM 0.710375657093538 0.228605209418247 no 779 0.238735607279006 1122 837851 SGTC_646 4092-0839 27.3 µM 0.710133487826338 0.228682992521546 no 780 0.238810680777954 1202 877796 SGTC_3350 9150499 3.57 µM 0.707358190189036 0.229575459341652 no 781 0.239671956124662 1168 4910996 YPR165W RHO1 SGTC_3088 9117578 49.47 µM 0.704933597544915 0.230356742562987 no 782 0.240425780291049 1237 678341 SGTC_839 0122-0028 230 µM 0.70317113238859 0.230925598448688 no 783 0.240974553523341 1176 759448 SGTC_2931 9014674 55.67 µM 0.702144408664984 0.23125734653174 no 784 0.241294555007575 1191 2996810 SGTC_3145 9085516 49.47 µM 0.701642379650868 0.23141965551101 no 785 0.241451107631434 1193 25236195 SGTC_1424 4048-1941 275 µM 0.701534199138947 0.231454639233865 no 786 0.241484849843639 1232 X1424 SGTC_1796 st049173 110.4 µM 0.701175411866429 0.231570685991052 no 787 0.241596776280266 1147 94134 SGTC_2190 6049624 200 µM 0.700981854902563 0.231633303845056 no 788 0.241657169551599 1126 2265554 SGTC_2432 5630864 12.22 µM 0.700318530803721 0.231847968216351 no 789 0.241864200816224 1159 5714970 SGTC_229 benomyl 22.8748 µM 0.699491382633922 0.232115804363751 no 790 0.242122498264833 1195 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_3299 9121982 43.1275 µM 0.698425277198458 0.232461270384873 no 791 0.242455636517333 1216 17594604 YPL160W CDC60 SGTC_1688 st021091 57.6 µM 0.697096267349271 0.232892329364356 no 792 0.242871275000269 1197 3656366 SGTC_1901 st060216 58.6 µM 0.696040359857849 0.233235124998695 no 793 0.243201777291779 1203 688792 SGTC_3169 9102970 49.47 µM 0.695449821401565 0.233426962702338 no 794 0.243386723608337 1250 17027839 SGTC_2329 6138490 200 µM 0.694282141381465 0.233806543629108 no 795 0.243752644161445 1144 720019 SGTC_1131 3454-3128 32.3 µM 0.694233062175733 0.233822505428047 no 796 0.243768030809047 1235 710982 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.69311742981783 0.234185500123837 no 797 0.24411793011881 1276 688664 SGTC_2450 5739737 12.93 µM 0.692477290774914 0.234393923756974 no 798 0.244318821179399 1195 2262825 SGTC_2761 levamisole 97.89 µM 0.692083921243131 0.234522052313132 no 799 0.244442314207176 1199 26879 An alkaline phosphatase inhibitor. SGTC_163 TUB2.036 7.546 µM 0.691059671431069 0.234855853276157 no 800 0.244764021274339 1230 15992207 YJR013W GPI14 SGTC_2534 helenine 20.12 µM 0.690677139609021 0.234980586947969 no 801 0.244884229293069 1206 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_92 0063-0024 660.874 µM 0.690616814644334 0.235000260689732 no 802 0.244903188901976 1251 3594437 SGTC_1631 benzylvanillin 81.9 µM 0.69015158903949 0.23515201498369 no 803 0.245049431774294 1204 75506 SGTC_2484 5809818 12.04 µM 0.689342301251203 0.235416129576156 no 804 0.245303941898375 1204 2870548 SGTC_2184 6075246 200 µM 0.688582937402529 0.23566410008 no 805 0.245542880769605 1214 2267320 SGTC_2807 7945238 51.95 µM 0.687809788747301 0.235916719952223 no 806 0.245786285514889 1225 17148797 SGTC_2558 carylophyllene oxide 100 µM 0.685860791406564 0.236554200436734 no 807 0.246400448511936 1295 6708694 An oxygenated terpenoid and antifungal agent. SGTC_65 0798-0905 34.986 µM 0.68571018938518 0.236603498954033 no 808 0.246447940039799 1308 3602145 SGTC_752 1896-0090 130 µM 0.684272404688342 0.237074432175598 no 809 0.24690158446447 1211 772567 SGTC_2803 7707263 71.43 µM 0.683157243236172 0.237440047493657 no 810 0.247253743518828 1199 2199229 SGTC_370 0180-0345 38.7 µM 0.682736089923186 0.23757820673026 no 811 0.247386810193963 1161 3989527 SGTC_1040 k898-0338 155 µM 0.682213643141676 0.23774965655497 no 812 0.2475519345089 1257 20969351 SGTC_2894 9048625 32.47 µM 0.682004958364235 0.237818158989284 no 813 0.247617907787362 1275 4092861 SGTC_2253 7938677 135.83 µM 0.681560445678405 0.237964109885024 no 814 0.247758466632837 1243 2301972 SGTC_1965 Pectolinarigenin 58.4 µM 0.681065317430799 0.238126737642924 no 815 0.247915080707357 1225 5320438 An anti-inflammatory. SGTC_3051 9093778 49.47 µM 0.679910002697986 0.238506444244375 no 816 0.248280723832925 1233 17217378 SGTC_538 2922-0838 53.3 µM 0.67742127546807 0.239325516055767 no 817 0.249069351661091 1259 777039 SGTC_2855 9016525 58.44 µM 0.675794579176768 0.239861711778716 no 818 0.249585538445483 1242 43811474 SGTC_2487 5918373 44.05 µM 0.672696420337525 0.240884744705426 no 819 0.250570222706805 1269 2876279 SGTC_1321 1326-2144 215 µM 0.672235436889623 0.241037167153142 no 820 0.250716912247733 1210 3513030 SGTC_602 3130-1533 38.1 µM 0.671773066907684 0.241190100720049 no 821 0.250864088667538 1248 720941 SGTC_2482 5981709 142.65 µM 0.670127910565814 0.241734680327418 no 822 0.251388126994633 1226 877755 SGTC_27 0485-0001 32.618 µM 0.669401362867299 0.241975394404798 no 823 0.251619741240959 1179 2054479 SGTC_2992 9074591 71.4286 µM 0.665804768007826 0.243168902474287 no 824 0.252767948438206 1246 17741321 SGTC_699 0375-0592 111 µM 0.664828566042837 0.243493397464475 no 825 0.253080074705031 1277 762578 SGTC_107 0358-0022 2.6945 µM 0.662812292271743 0.244164357987841 no 826 0.253725389989238 1241 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.661548741245652 0.244585340656084 no 827 0.254130233752026 1267 6708739 YPR165W RHO1 SGTC_3159 9100096 49.47 µM 0.661225723798703 0.244693024463561 no 828 0.254233783408026 1215 25236875 SGTC_649 1123-0311 367 µM 0.660988981956601 0.244771962919056 no 829 0.254309689752672 1234 693629 YIL048W NEO1 SGTC_1193 1488-0126 41.5 µM 0.659563243192506 0.245247646513921 no 830 0.25476707431766 1274 1384710 SGTC_1728 st035614 33.7865 µM 0.659318680279004 0.245329292413139 no 831 0.254845574650527 1255 15945546 SGTC_1272 0839-0021 27 µM 0.658685883792334 0.245540615611956 no 832 0.255048749780814 1259 5027250 SGTC_1357 1503-1303 39.5 µM 0.658553895377584 0.245584705634511 no 833 0.255091138638556 1258 292895 SGTC_80 0159-0065 512.242 µM 0.657230755895357 0.246026928180099 no 834 0.255516276228109 1200 1548079 SGTC_422 cantharidin 155 µM 0.655451653572975 0.246622216371514 no 835 0.256088502049447 1227 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_417 st075190 100 µM 0.652363540288591 0.247657329067571 no 836 0.257083339405472 1266 222757 SGTC_1422 4031-0024 15.5 µM 0.649037008393631 0.248774948682201 no 837 0.258157227790067 1221 782427 SGTC_1801 st050089 28.441 µM 0.648682831670652 0.248894099913295 no 838 0.258271701807113 1285 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_802 4112-3352 742 µM 0.648570409484933 0.248931927048742 no 839 0.258308043459054 1342 704594 SGTC_1764 st044502 93.5 µM 0.647882223393944 0.249163550407728 no 840 0.258530564588108 1259 8407 SGTC_2337 9009472 200 µM 0.646512790747952 0.249624802264411 no 841 0.258973658137787 1317 5742383 SGTC_324 1315-0088 19.6 µM 0.646503159644783 0.249628047814822 no 842 0.258976775767359 1217 6787421 SGTC_1939 st074455 53.6 µM 0.646378282939147 0.249670131590822 no 843 0.259017200652289 1324 1644229 SGTC_2016 5121758 140 µM 0.646046013508849 0.249782125606152 no 844 0.25912477826553 1257 2795203 SGTC_3293 9120939 62.045 µM 0.645623796460889 0.249924475643728 no 845 0.25926151119642 1284 934087 SGTC_1109 tnp00067 928.257 nM 0.645177784357955 0.250074894911169 no 846 0.259405990527542 1246 676295 SGTC_896 0964-0007 44.5 µM 0.645161451099014 0.250080404275961 no 847 0.25941128224579 1249 6756758 SGTC_355 1311-2252 105 µM 0.644924088419269 0.250160476249777 no 848 0.259488190302811 1240 5338538 SGTC_1514 1189-1591 158 µM 0.641936466906678 0.251169482724679 no 849 0.260457217672546 1342 767698 YMR146C TIF34 SGTC_1412 3909-8563 178 µM 0.641829778508738 0.251205554255566 no 850 0.260491856211748 1343 23767530 SGTC_482 fipronil 114 µM 0.641038437821117 0.251473193403339 no 851 0.26074885494962 1304 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2648 atorvastatin 78.68 µM 0.640512151155323 0.251651272089044 no 852 0.260919845967357 1290 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1364 1653-0028 37.6 µM 0.639416234351263 0.252022309167408 no 853 0.261276095318121 1271 5718652 SGTC_2777 climbazole 1.536 µM 0.639313820736343 0.25205699738806 no 854 0.261309399644482 1267 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_133 0724-0033 378.92 µM 0.638185026864906 0.252439494733701 no 855 0.261676621432818 1182 280309 SGTC_1837 st055472 66.5 µM 0.636792204482911 0.252911880696557 no 856 0.262130102268227 1335 676091 SGTC_1021 4476-0760 85.3 µM 0.635596183630006 0.253317890945823 no 857 0.262519828793122 1256 746768 SGTC_593 1203-0218 61.7 µM 0.632926871346666 0.254225270060568 no 858 0.263390699560508 1327 3666956 SGTC_2869 9037858 32.47 µM 0.632587292310336 0.254340825208909 no 859 0.263501593852555 1250 27187042 SGTC_312 4092-0653 6.84 µM 0.63160124155199 0.25467652381644 no 860 0.263823737544298 1311 1148278 SGTC_1128 3448-9350 235 µM 0.63008233095637 0.255194086912483 no 861 0.26432035964333 1286 619386 SGTC_400 oxethazaine 37.5 µM 0.629249189866676 0.25547821001911 no 862 0.264592964945006 1276 4621 A local anesthetic. SGTC_1840 st055363 71 µM 0.627749442315281 0.255990079763209 no 863 0.265084045309131 1240 676033 SGTC_2506 ethyl hematommate 54.16 µM 0.627685237309128 0.256012005121744 no 864 0.265105079055596 1258 3940691 An allergen. SGTC_2123 5259487 200 µM 0.626359951309735 0.256464795571114 no 865 0.265539435856927 1279 2173474 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.625769525320018 0.256666651762663 no 866 0.265733061616672 1239 1241132 A phosphatase inhibitor. SGTC_2363 9053361 176 µM 0.62236684029485 0.257831579700248 no 867 0.266850339713934 1383 6469797 YMR079W SEC14 SGTC_1920 st075728 45.7 µM 0.622110948246395 0.257919296549231 no 868 0.266934458213528 1370 3400306 SGTC_1370 2001-0092 44.6 µM 0.621396821177197 0.258164172959215 no 869 0.267169281538262 1425 790957 SGTC_40 0327-0103 19.753 µM 0.620391367414455 0.258509150418362 no 870 0.267500077225786 1273 409036 SGTC_1283 0922-0125 16.4 µM 0.617944351086039 0.259349733522716 no 871 0.268306011046012 1308 3360884 SGTC_1091 telmisartan 47.6 µM 0.616240180091223 0.259935972339886 no 872 0.268868006640665 1371 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_2232 chlorophetanol 41.5365 µM 0.613359911227295 0.260928343078894 no 873 0.269819193592802 1377 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_127 0180-0333 59.125 µM 0.611400386661616 0.261604591607548 no 874 0.270467273367361 1289 771601 SGTC_3258 9138477 49.47 µM 0.610188531959199 0.262023262661961 no 875 0.270868462821368 1365 4970355 SGTC_2375 9072683 200 µM 0.609725387424544 0.262183360311943 no 876 0.271021867116807 1382 16798029 SGTC_1503 4585-0012 61.3 µM 0.608835151843722 0.262491233508659 no 877 0.271316855609513 1354 2922052 SGTC_992 3909-8734 162 µM 0.608099543483488 0.262745771017962 no 878 0.271560727501327 1324 4288319 SGTC_1703 st026983 48.3 µM 0.60640814427311 0.263331512796398 no 879 0.27212188082735 1349 1104023 SGTC_1431 4049-0260 9.09 µM 0.605090105544119 0.263788419385671 no 880 0.272559564096547 1341 3854841 SGTC_2731 amoxapine 43.43 µM 0.604095319146909 0.264133535984343 no 881 0.2728901357056 1378 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1522 st012842 45.6 µM 0.603794639190136 0.264237894726447 no 882 0.272990092009352 1267 3491067 YOR116C RPO31 SGTC_2303 7774051 200 µM 0.603214764304215 0.264439214555168 no 883 0.273182913503805 1390 2953184 SGTC_2635 hydroquinidine 100 µM 0.602870659178132 0.264558717195607 no 884 0.273297368124351 1358 442912 An experimental heart treatment. SGTC_2565 isoliquiritigenin 100 µM 0.601714119800799 0.2649605675403 no 885 0.273682224763796 1282 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3268 9137683 49.47 µM 0.600488140320298 0.26538688389551 no 886 0.274090481210144 1351 1953228 SGTC_1634 st006576 41 µM 0.600405330105016 0.265415692477317 no 887 0.274118068213046 1365 3915356 SGTC_1266 0828-0227 32.9 µM 0.598113275367153 0.266213697418583 no 888 0.274882176434489 1352 3913820 SGTC_34 0469-0683 81.75 µM 0.597606010706434 0.266390471391882 no 889 0.275051426324878 1366 3690923 SGTC_173 1273-0061 2.693 µM 0.597595024166851 0.266394300689828 no 890 0.275055092574091 1292 2847414 YPL266W DIM1 SGTC_2170 morpholine 200 µM 0.597229844068945 0.266521598050243 no 891 0.275176968229353 1403 121171 Reacts with secondary amines. SGTC_689 0833-0039 98 µM 0.596369856216681 0.266821500888849 no 892 0.275464086631082 1351 5374726 SGTC_3193 9111931 49.47 µM 0.595813292604476 0.267015681696517 no 893 0.275649981324277 1383 17087244 SGTC_365 0121-0052 13.6 µM 0.594780297088451 0.267376275017918 no 894 0.275995169750013 1370 3101739 SGTC_1434 4073-0095 163 µM 0.594160874228114 0.267592618052585 no 895 0.276202259441564 1334 24133745 SGTC_2054 5233173 129 µM 0.593702782623597 0.26775267038941 no 896 0.276355460800362 1382 6889 SGTC_315 k915-0449 187 µM 0.593332693897177 0.26788201067319 no 897 0.276479261447597 1386 20970215 YNL149C PGA2 SGTC_527 4476-4215 268 µM 0.593257457114982 0.267908308612988 no 898 0.276504432690283 1370 4418754 SGTC_156 3474-0145 5.642 µM 0.592699227781754 0.268103470286147 no 899 0.276691229168141 1303 2265471 SGTC_1447 4239-0816 81.9 µM 0.590531729199074 0.268861923740015 no 900 0.277417110072018 1297 1341554 SGTC_2483 5729050 27.16 µM 0.588739952958734 0.269489716487593 no 901 0.278017866086896 1431 2865180 SGTC_3329 9141233 27.5565 µM 0.587972481447241 0.269758843520411 no 902 0.278275381942092 1416 4909101 YNL103W MET4 SGTC_542 3381-0244 89.3 µM 0.587689539441259 0.269858095927662 no 903 0.278370349065943 1419 1112843 SGTC_1124 fisetin 1.16336 µM 0.586896795746173 0.270136277526551 no 904 0.278636510967862 1367 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_387 norethindrone acetate 66.7 µM 0.586455183037812 0.270291305976276 no 905 0.27878483516151 1354 541197 SGTC_1744 st037937 38.9 µM 0.58219632250119 0.271788661098132 no 906 0.280217225080469 1412 1016152 SGTC_2027 5150920 200 µM 0.582146455047099 0.271806218210036 no 907 0.280234018183548 1361 786715 SGTC_2198 6589944 200 µM 0.582065495905562 0.27183472314711 no 908 0.280261282598906 1339 5290268 SGTC_293 4049-0273 38.5 µM 0.581762235633341 0.271941511399187 no 909 0.280363422250658 1308 1380311 SGTC_702 1488-0190 94 µM 0.581705997339064 0.271961317107982 no 910 0.280382365584496 1378 949357 SGTC_1087 pterostilbene 9.05 µM 0.579074358555046 0.272888915416093 no 911 0.281269500380338 1458 5281727 Similar to reservatol, lowers cholesterol. SGTC_688 0527-0193 473 µM 0.575459124675534 0.274165763689233 no 912 0.282490413708961 1394 4007154 SGTC_2004 4023728 41.89 µM 0.574880377814539 0.274370442394025 no 913 0.282686100723386 1366 360084 YDR527W RBA50 SGTC_2021 4019055 173 µM 0.574287171406012 0.274580313088759 no 914 0.282886744406373 1382 44827708 YER133W GLC7 SGTC_2563 tomatine 8.54 µM 0.573776838289837 0.274760927360886 no 915 0.283059412077289 1420 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2465 5809242 33.21 µM 0.573644888556288 0.274807635808697 no 916 0.283104064583349 1394 2731748 SGTC_960 1222-0186 7.7 µM 0.573542263518894 0.274843966410538 no 917 0.283138795789774 1429 3126296 SGTC_1348 1493-0373 93.8 µM 0.570801322136327 0.275815170460678 no 918 0.284067163307711 1405 3010129 SGTC_132 0417-1715 25.805 µM 0.569151500080279 0.276400567592131 no 919 0.284626665559214 1457 6769098 SGTC_2623 humulene 100 µM 0.568334059685745 0.276690840987856 no 920 0.284904077974105 1334 6187145 An anti-inflammatory. SGTC_234 nsc-17383 10.7 µM 0.565116084386572 0.277834994580867 no 921 0.285997404484234 1434 408974 SGTC_1833 st055984 71 µM 0.564752239881728 0.277964504976974 no 922 0.286121148216417 1386 676288 SGTC_628 1636-0253 16 µM 0.56408555171631 0.278201888949738 no 923 0.286347955237309 1414 4456143 SGTC_2492 derrusnin 100 µM 0.562767084232049 0.278671639252322 no 924 0.286796748415415 1328 1715307 Part of coumarin class of compounds. SGTC_2010 4012422 159 µM 0.562474177416736 0.278776049986916 no 925 0.286896496215296 1431 952393 SGTC_1386 3228-0095 33.8 µM 0.559801160714716 0.279729762960895 no 926 0.287807535925086 1445 870181 SGTC_3291 9121177 71.43 µM 0.557663046460251 0.280493764510052 no 927 0.288537248033286 1370 17015612 SGTC_1175 0741-0056 27.6 µM 0.557328043263219 0.280613560965324 no 928 0.288651659453094 1491 765927 SGTC_2013 4024628 200 µM 0.55686942710471 0.28077760129239 no 929 0.288808322227985 1421 5230760 SGTC_1656 st012921 11 µM 0.556434004966467 0.280933388356692 no 930 0.288957098982142 1412 6732821 SGTC_1808 st050063 61.5 µM 0.556138162972203 0.281039259711971 no 931 0.289058204011312 1440 4011993 SGTC_2339 9000433 200 µM 0.554750092557335 0.281536258119771 no 932 0.289532803939505 1367 2988954 SGTC_23 0213-0011 39.996 µM 0.55361191561772 0.281944098291035 no 933 0.289922234753704 1465 627608 SGTC_2101 5377231 179.231 µM 0.553118499576035 0.282120991251023 no 934 0.29009113489314 1476 2844213 SGTC_655 k060-0012 42 µM 0.551396018598647 0.282738930729542 no 935 0.290681114693709 1375 5994525 SGTC_1284 0929-0043 16 µM 0.548668821716612 0.283718639555432 no 936 0.291616373226361 1395 1239883 SGTC_2721 ifenprodil 61.44 µM 0.546472921203591 0.284508666967266 no 937 0.292370448272967 1460 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1086 cerivastatin 2.18 µM 0.545840831201052 0.284736270978869 no 938 0.292587676726604 1425 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_813 k007-0158 173 µM 0.545761316702113 0.284764908843482 no 939 0.292615008542528 1479 6523916 SGTC_2371 9071574 200 µM 0.544388203410552 0.285259664687276 no 940 0.293087180898929 1394 45596039 SGTC_1481 3346-2004 36 µM 0.544270216087636 0.285302196607269 no 941 0.293127769672197 1408 2770522 SGTC_535 2293-4129 48.2 µM 0.54388192131845 0.285442189937554 no 942 0.293261365207705 1487 396118 YIL048W NEO1 SGTC_1023 4482-3888 16 µM 0.543710316185345 0.285504069782634 no 943 0.293320416147417 1497 3303168 SGTC_3209 9113616 49.47 µM 0.540221047201119 0.286763663483023 no 944 0.294522299711106 1505 16649353 SGTC_261 5-fluorouridine 15.376 µM 0.539903620369733 0.286878382220473 no 945 0.294631750511967 1476 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3288 9119690 36.221 µM 0.536621876485239 0.288065684217216 no 946 0.295764414883311 1376 17595618 YKL019W RAM2 SGTC_641 4092-0595 30 µM 0.536271709972274 0.288192507749259 no 947 0.295885389733565 1453 786260 SGTC_2998 9066762 71.4286 µM 0.536178260300835 0.28822635786326 no 948 0.295917678386532 1525 4945196 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.534734434749141 0.288749590485279 no 949 0.296416753273146 1449 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3018 9082602 49.47 µM 0.532385787317783 0.289601678611856 no 950 0.297229413410295 1429 17332089 SGTC_218 alverine citrate 93.75 µM 0.532253611981685 0.289649666824152 no 951 0.297275177910227 1478 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1242 0402-0103 60.1 µM 0.531613366547964 0.289882170218877 no 952 0.297496902589572 1397 432868 SGTC_1062 mesoridazine 14.2 µM 0.530934063763259 0.290128952848711 no 953 0.297732235823953 1445 4078 A neuroleptic. SGTC_1315 1237-0019 3.69 µM 0.530341134083667 0.2903444375937 no 954 0.297937715911853 1497 825140 SGTC_2246 7293507 91.5585 µM 0.528367003731043 0.29106242311168 no 955 0.298622317288764 1552 887656 SGTC_479 n-linoleoylglycine 10 µM 0.527980259009052 0.291203178145192 no 956 0.29875651881699 1447 6433346 An anti-infammatory. SGTC_3303 9125618 40.5795 µM 0.526088370416581 0.291892185078383 no 957 0.299413404259689 1524 22695467 SGTC_741 4582-0002 126 µM 0.525472487839192 0.292116647075538 no 958 0.299627386976623 1415 2912688 SGTC_1739 st037196 92.5 µM 0.524145409662898 0.292600581293686 no 959 0.300088703376761 1517 612214 SGTC_671 0560-0003 407 µM 0.52390050751685 0.292689928355111 no 960 0.300173870898532 1478 3238678 SGTC_894 0960-0238 55.9 µM 0.523425228635801 0.292863359356264 no 961 0.300339185743996 1455 6741907 YDL195W SEC31 SGTC_1054 3429-0080 167 µM 0.520715222680118 0.293853160654592 no 962 0.301282584163447 1505 1162877 SGTC_2970 9090938 41.86 µM 0.520146734378807 0.294060991243278 no 963 0.301480653665601 1558 17217104 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.51910708764419 0.294441245756558 no 964 0.301843033028454 1454 616764 SGTC_359 0081-0058 15.9 µM 0.51882327159659 0.294545091917692 no 965 0.301941993980059 1610 3494159 SGTC_1569 carminic acid 40.6 µM 0.518627839006903 0.294616609059087 no 966 0.302010145868985 1489 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_521 r062-0005 13.8 µM 0.518581042609087 0.294633735050768 no 967 0.302026465886356 1443 2832033 SGTC_1452 4194-0072 190 µM 0.518429309228246 0.294689267795502 no 968 0.302079384892812 1559 1343545 SGTC_1883 5-benzylidenerhodanine 20 µM 0.517492438551115 0.295032259007943 no 969 0.302406222999364 1518 1273210 SGTC_1643 st009866 20.2 µM 0.517465077443388 0.295042278756091 no 970 0.302415770619407 1465 3156273 YOR207C RET1 SGTC_1365 1672-3266 55.4 µM 0.517038560698294 0.295198491172719 no 971 0.30256462051215 1492 6415873 SGTC_1754 st042065 16.137 µM 0.51636454626401 0.295445427598481 no 972 0.302799911438224 1389 1126236 YIL048W NEO1 SGTC_3295 9122362 53.5725 µM 0.515890842780119 0.295619033601043 no 973 0.302965325058377 1442 4730473 SGTC_2297 7971671 152.32 µM 0.515764232451791 0.295665442536557 no 974 0.303009543261106 1539 909016 SGTC_796 1234-0020 70.7 µM 0.515476151920604 0.295771050748009 no 975 0.303110165111639 1422 46495034 SGTC_2292 7671323 168.05 µM 0.512602811779378 0.296825343335322 no 976 0.304114592970344 1446 937504 SGTC_53 0973-0023 39.979 µM 0.510768301723925 0.297499364387489 no 977 0.304756653790003 1470 674768 SGTC_1126 isoteolin 1.0172 µM 0.510083904900309 0.297750998877234 no 978 0.30499634032124 1412 133323 SGTC_1523 st012844 44.7 µM 0.505820897451007 0.299320574409005 no 979 0.30649119346323 1498 4274103 SGTC_3044 9093193 49.47 µM 0.505407404365251 0.29947301583943 no 980 0.306636359681641 1420 25236277 SGTC_662 k832-1615 104 µM 0.504547588005197 0.299790114750866 no 981 0.306938315025868 1524 5878478 SGTC_2377 9073351 62.6 µM 0.503452059456615 0.300194364063348 no 982 0.307323238958386 1440 7337946 YHR072W ERG7 SGTC_1319 1306-0155 43.7 µM 0.50307802324594 0.300332439596764 no 983 0.307454708634382 1504 3122360 SGTC_3161 9100388 49.47 µM 0.499062583194537 0.301816544232351 no 984 0.308867647988024 1556 25236368 SGTC_2062 5245942 200 µM 0.498813160820652 0.301908839257319 no 985 0.308955507554551 1510 1376160 SGTC_609 0986-0026 86.3 µM 0.498413195345499 0.302056866973884 no 986 0.309096419069858 1526 2848610 SGTC_2314 7727897 200 µM 0.498189815703654 0.302139554237023 no 987 0.309175129999558 1444 900724 SGTC_2244 6635614 200 µM 0.49798852437991 0.30221407388673 no 988 0.309246065306047 1489 836499 SGTC_69 0096-0274 206.684 µM 0.497856136701608 0.302263089354696 no 989 0.309292722760861 1569 6741392 SGTC_2067 5224629 34.075 µM 0.497784125781338 0.302289752313719 no 990 0.30931810289641 1455 2835000 SGTC_2219 9098279 200 µM 0.497405495235822 0.302429962445931 no 991 0.309451565602045 1521 902349 SGTC_3115 9123671 49.47 µM 0.496632571208583 0.302716273318886 no 992 0.309724090028681 1556 3286988 SGTC_600 1495-0418 41.6 µM 0.49646756873398 0.302777410188634 no 993 0.309782281625009 1493 5377768 SGTC_1140 3229-1848 2.98 µM 0.496073293793365 0.30292351969337 no 994 0.309921350286148 1549 2849525 SGTC_1877 wortmannin 25 µM 0.495391195234419 0.3031763647123 no 995 0.310162004326523 1520 312145 A covalent inhibitor of PI 3-kinase. SGTC_183 3914-0051 30.55 µM 0.494191943091064 0.303621140474444 no 996 0.310585314635351 1613 1596232 SGTC_336 4111-0029 111 µM 0.492993924932155 0.30406574920468 no 997 0.311008439940801 1450 3131175 SGTC_1732 st034308 51.822 µM 0.492356105161429 0.304302575309729 no 998 0.311233812053681 1464 830119 SGTC_3348 9149464 3.537 µM 0.492306827812922 0.304320875686926 no 999 0.311251227035214 1472 1951442 SGTC_2112 5488546 200 µM 0.492218316463123 0.304353747823438 no 1000 0.311282508665601 1454 600757 SGTC_1714 st033236 13.627 µM 0.492118457744431 0.304390836145034 no 1001 0.311317802312733 1589 2916566 SGTC_1882 5615643 20 µM 0.490627094875767 0.304944979377971 no 1002 0.311845109592236 1432 2253075 SGTC_1488 4013-0813 75.9 µM 0.489846715521618 0.305235122131031 no 1003 0.312121185398625 1478 2910057 SGTC_2788 5282734 71.43 µM 0.488947569414513 0.305569573808003 no 1004 0.312439408337478 1637 743706 SGTC_2009 4012297 12.05 µM 0.487655518138177 0.306050456944452 no 1005 0.312896931991481 1480 45595307 SGTC_861 0443-0273 110 µM 0.487559552704919 0.306086187268571 no 1006 0.3129309254792 1520 6149169 SGTC_2206 7254556 146.969 µM 0.486031187026127 0.306655484414485 no 1007 0.313472527138961 1539 4398905 SGTC_2383 9036125 200 µM 0.484890635465408 0.307080629888052 no 1008 0.313876962743751 1533 79580 SGTC_1222 0366-0074 1.18 µM 0.483734166748042 0.307511973527196 no 1009 0.314287270952157 1608 286520 SGTC_3066 9117245 49.47 µM 0.483594071649273 0.307564244769625 no 1010 0.314336991458227 1599 17176980 SGTC_809 3998-0021 90 µM 0.483063685892056 0.307762173755852 no 1011 0.314525258735514 1501 715485 SGTC_831 k061-1017 217 µM 0.481528369836878 0.30833543721044 no 1012 0.315070510804776 1592 1240153 SGTC_1530 rhein 70.4 µM 0.481219034122841 0.308450995073492 no 1013 0.315180417115654 1522 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_198 3454-2873 16.191 µM 0.4797699639644 0.308992573574348 no 1014 0.315695486324307 1501 710957 SGTC_1467 k284-1082 293 µM 0.479482992279455 0.309099876293911 no 1015 0.315797532379927 1589 3334705 SGTC_2685 mycophenolic acid 18.85 µM 0.478768755465784 0.309367010116753 no 1016 0.316051573267324 1553 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2359 9039622 200 µM 0.478694393282322 0.309394828331859 no 1017 0.316078027522783 1562 6463596 SGTC_985 1493-0307 8.71 µM 0.478502866722687 0.309466481701991 no 1018 0.316146167197121 1599 3278274 SGTC_2078 5212016 200 µM 0.477096498272951 0.30999285000935 no 1019 0.31664670405003 1552 1899708 SGTC_2713 st079149 53.4 µM 0.47687273314482 0.310076635623589 no 1020 0.316726374700666 1547 3103253 SGTC_2405 ticlatone 3.52 µM 0.476825937281781 0.31009415890439 no 1021 0.316743037249644 1356 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1456 k015-0012 13 µM 0.476427502085365 0.310243375281999 no 1022 0.316884922667157 1681 2989616 SGTC_1699 st031318 29.054 µM 0.476100728589988 0.310365777244412 no 1023 0.31700130898287 1573 5340658 SGTC_1045 1348-1485 165 µM 0.475168409566901 0.310715118295622 no 1024 0.317333470840362 1494 6810614 SGTC_974 1326-0144 138 µM 0.473383788511097 0.311384293922283 no 1025 0.317969696831939 1499 5411856 SGTC_1795 st049545 62.3 µM 0.472345405587295 0.31177394137438 no 1026 0.318340132898307 1585 5291882 SGTC_2159 5658611 73.75 µM 0.4718816485679 0.311948031756921 no 1027 0.318505633795941 1532 793844 SGTC_2913 7966556 36.57 µM 0.471682651357876 0.312022746477495 no 1028 0.318576661007972 1600 2976516 SGTC_1471 k673-0312 37 µM 0.471587794197493 0.31205836390119 no 1029 0.318610520309897 1518 24099884 SGTC_3342 9147791 14.508 µM 0.471186650282495 0.312209006775368 no 1030 0.318753725537308 1491 1838168 SGTC_2173 5763948 167 µM 0.470144026119303 0.312600693634402 no 1031 0.319126060746762 1524 2867177 SGTC_3078 9116413 49.47 µM 0.469863721627997 0.312706032898476 no 1032 0.319226192427263 1449 17177322 SGTC_1044 1222-0021 1.78 µM 0.469000463882554 0.313030543818446 no 1033 0.31953465222093 1549 4306703 SGTC_1473 k844-0725 134 µM 0.468683600403349 0.313149693693573 no 1034 0.319647905424791 1560 54682906 SGTC_1579 chlormadinone acetate 49.4 µM 0.467597131714843 0.313558385581513 no 1035 0.320036358239677 1630 45114258 A steroidal progestin. SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.467125092702648 0.313736021689587 no 1036 0.32020519121087 1481 4174840 SGTC_1436 4092-1007 8.32 µM 0.466482708036289 0.313977831069105 no 1037 0.320435011075704 1520 2881121 SGTC_2698 st077697 67.5 µM 0.465989762491635 0.314163442077484 no 1038 0.320611414235518 1480 3154499 SGTC_2974 9094440 9.66 µM 0.465898146948338 0.314197943672862 no 1039 0.320644203807123 1637 25236134 SGTC_146 3448-8650 53.125 µM 0.465072859027009 0.314508812892485 no 1040 0.320939640739963 1559 2891488 YIL048W NEO1 SGTC_2627 acetyl isogambogic acid 100 µM 0.464986868187371 0.314541211469316 no 1041 0.32097043030559 1463 6857789 A caspase activator and apoptosis inducer. SGTC_666 0272-0154 136 µM 0.464540577235321 0.314709382452131 no 1042 0.321130247383716 1540 6870312 SGTC_1383 3049-0032 20.7 µM 0.464235302081306 0.314824438122124 no 1043 0.321239585700469 1631 712864 SGTC_2114 5491910 81.25 µM 0.462478914742979 0.315486754888906 no 1044 0.321868959773531 1618 2849228 SGTC_280 3448-3607 3.04 µM 0.461977809312578 0.315675825786788 no 1045 0.322048616947915 1562 626179 SGTC_972 1319-0219 195 µM 0.459921212432897 0.316452300420306 no 1046 0.322786386855607 1497 23903702 SGTC_1791 st048313 56.1 µM 0.458975377649243 0.316809675391398 no 1047 0.323125923872964 1628 1204976 SGTC_1618 st003135 44.5 µM 0.458543370302541 0.316972962307673 no 1048 0.323281055501578 1527 1270615 SGTC_1765 st044815 90.4 µM 0.457227253951325 0.317470637803809 no 1049 0.323753855494433 1471 645695 SGTC_1984 st072354 53.1 µM 0.457072397430669 0.317529216884461 no 1050 0.323809504683159 1554 5762938 SGTC_3098 9119039 49.47 µM 0.456505942002981 0.317743534402164 no 1051 0.324013099470244 1534 17161528 SGTC_345 1362-0200 395 µM 0.456228103339686 0.317848676553479 no 1052 0.324112979187235 1498 1419823 SGTC_186 3455-3465 67.277 µM 0.454675550182994 0.318436477533553 no 1053 0.324671336585807 1535 755278 SGTC_2564 betulinic acid 100 µM 0.454005162170229 0.318690429779866 no 1054 0.324912555659631 1750 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_799 1310-0557 151 µM 0.453471443874528 0.318892670555754 no 1055 0.325104650727988 1571 5354492 SGTC_2402 5553605 200 µM 0.451189062148936 0.319758136686616 no 1056 0.32592664609472 1625 6758546 SGTC_648 0375-0473 33.3 µM 0.450394896094538 0.320059510526304 no 1057 0.326212862251285 1578 1713139 SGTC_1669 st015249 58.4 µM 0.450109887281773 0.320167695972287 no 1058 0.326315603939597 1612 722793 SGTC_3312 9133330 71.43 µM 0.449868022382229 0.320259516573182 no 1059 0.326402803190388 1630 17617324 SGTC_1280 0880-0253 10.1 µM 0.44931303870183 0.320470249904326 no 1060 0.326602926623674 1532 6836607 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.449170563182182 0.320524358748293 no 1061 0.326654310403818 1542 442882 SGTC_3198 9112019 49.47 µM 0.448904187613941 0.320625532142618 no 1062 0.326750387543373 1586 45595555 SGTC_3025 9087895 49.47 µM 0.448793374703828 0.320667624456403 no 1063 0.326790359260693 1626 17173641 SGTC_414 piperonyl butoxide 100 µM 0.4476208186164 0.321113161413956 no 1064 0.327213437851307 1517 5794 A potent inhibitor of cytochrome P450. SGTC_2734 clemastine 41.6 µM 0.446212198507757 0.321648736425875 no 1065 0.327721986089989 1581 26987 Clemastine is a selective histamine H1 antagonist. SGTC_425 3825-7017 13.1 µM 0.444883461535793 0.322154278839396 no 1066 0.328201987527299 1632 3397440 SGTC_2096 5468907 200 µM 0.444450706256454 0.322318999658759 no 1067 0.328358380116956 1676 759785 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.443339901026351 0.322741968156464 no 1068 0.328759949516471 1598 2724278 An inhibitor of dopamine biosynthesis. SGTC_2074 5212007 75.395 µM 0.440902137963351 0.323671014666852 no 1069 0.329641922910433 1660 758611 SGTC_2612 dictamnine 15.46 µM 0.439882283567732 0.324060014156511 no 1070 0.330011183990867 1559 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_634 1611-4317 11.2 µM 0.435244450263058 0.325831425648729 no 1071 0.331692500611277 1623 2843522 SGTC_2596 sinensetin 100 µM 0.435188760719474 0.325852720173921 no 1072 0.331712709996707 1546 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2030 5175110 200 µM 0.433515134943539 0.326492944743888 no 1073 0.332320286585925 1630 2831986 SGTC_1851 st056236 18.9 µM 0.433228333346617 0.326602708482624 no 1074 0.332424448505857 1686 5393171 SGTC_110 0850-0284 111.64 µM 0.432910323615693 0.326724433644504 no 1075 0.332539959870977 1493 3906265 SGTC_470 aa-861 153 µM 0.432192650285324 0.326999206539014 no 1076 0.332800700342023 1545 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1232 0279-0259 161 µM 0.431867763872393 0.327123625437516 no 1077 0.332918762592984 1564 1560000 SGTC_1411 3909-8223 150 µM 0.430872444056139 0.327504913887503 no 1078 0.333280560380881 1669 X1411 SGTC_1216 1165-0504 9.65 µM 0.43055130200648 0.327627975839728 no 1079 0.333397328333217 1669 6304004 SGTC_3082 9117008 49.47 µM 0.429724332417035 0.327944957584828 no 1080 0.333698090586032 1577 41448529 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.429464843908536 0.32804444644587 no 1081 0.333792486532078 1623 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_811 0416-0114 265 µM 0.42824969497708 0.328510501333471 no 1082 0.33423466963814 1586 6612453 SGTC_780 0109-0199 192 µM 0.427890502591888 0.328648316141659 no 1083 0.33436542100992 1720 610414 SGTC_2490 carminic acid 95.39 µM 0.426414663974122 0.329214809851734 no 1084 0.334902859001865 1574 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_76 0433-0009 400.328 µM 0.423761605056694 0.330234160011234 no 1085 0.335869840949833 1590 2841569 SGTC_1941 st076221 61.8 µM 0.421534159738387 0.331090956693258 no 1086 0.336682536279724 1697 2828568 SGTC_2809 7964133 12.99 µM 0.420903419738533 0.331333734640635 no 1087 0.336912803981249 1611 1253665 SGTC_197 4544-0043 41.561 µM 0.420410809910568 0.331523394262089 no 1088 0.337092686270981 1587 896523 SGTC_3275 9138069 49.47 µM 0.419241812439213 0.331973642620227 no 1089 0.33751970853503 1631 17617007 SGTC_506 n9-isopropylolomoucine 153 µM 0.418222710353036 0.332366355702509 no 1090 0.337892146426144 1753 6610355 SGTC_621 3584-0052 32.1 µM 0.41796948684553 0.332463964474858 no 1091 0.337984713343919 1689 2273927 SGTC_3247 9135149 49.47 µM 0.417047026616621 0.332819636552315 no 1092 0.338322005378985 1596 8934436 YOR116C RPO31 SGTC_1547 harmine 94.2 µM 0.415099169202587 0.333571164107189 no 1093 0.339034653806748 1609 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_745 0469-0705 296 µM 0.414533146884921 0.333789673811973 no 1094 0.339241848467439 1724 3486736 SGTC_1661 st013063 9.66 µM 0.41382212970398 0.334064237848168 no 1095 0.339502187950993 1614 721395 SGTC_730 1436-0052 41.2 µM 0.413256147172855 0.334282859295773 no 1096 0.33970947765689 1616 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2770 toltrazuril 17.5 µM 0.412617731521442 0.334529526883393 no 1097 0.339943354006969 1688 68591 Kills coccidiodes. SGTC_109 0132-0036 33.701 µM 0.412438467998619 0.334598802605825 no 1098 0.340009036253379 1587 67274 A color developer. SGTC_822 1487-0950 154 µM 0.411716282496685 0.334877945529697 no 1099 0.340273694564216 1669 1958375 SGTC_2158 5657123 3.6195 µM 0.411676664244058 0.334893261626042 no 1100 0.340288215688126 1626 2858827 SGTC_604 1000-0114 314 µM 0.411099664706136 0.335116356099037 no 1101 0.340499727915618 1700 1572745 SGTC_1486 3970-0793 4.53 µM 0.41038779541977 0.335391677563639 no 1102 0.340760748834045 1682 2844330 SGTC_794 k038-0031 316 µM 0.410334275706058 0.335412380341138 no 1103 0.340780375976818 1594 6624242 SGTC_259 usnic acid 108.925 µM 0.410111615986391 0.33549851611076 no 1104 0.34086203601208 1679 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1034 k072-0165 12.7 µM 0.40992132571395 0.335572136633122 no 1105 0.340931830523127 1740 5835461 SGTC_2202 7226349 200 µM 0.409374880940913 0.33578358320557 no 1106 0.341132285349989 1582 844334 SGTC_1769 st044406 64.4 µM 0.407932605154881 0.336341920800464 no 1107 0.341661577213063 1613 670903 SGTC_2408 sulbentine 18.36 µM 0.40725724684099 0.336603491509775 no 1108 0.341909529918606 1686 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2222 6885208 172.143 µM 0.405655252098205 0.337224270670912 no 1109 0.342497962807201 1632 609514 SGTC_2072 5231554 129 µM 0.405576061181476 0.337254968973163 no 1110 0.342527060562701 1763 789545 SGTC_2950 9072895 21.46 µM 0.405469774102674 0.337296172786336 no 1111 0.342566115947897 1549 17332245 SGTC_3318 9139014 38.6185 µM 0.405272029334155 0.337372836765373 no 1112 0.342638782110157 1627 16643984 SGTC_1185 1319-0113 81.3 µM 0.404968088626133 0.337490685178293 no 1113 0.342750483927463 1668 4672763 SGTC_2421 5690543 90.72 µM 0.404685995841332 0.337600076653268 no 1114 0.342854168676665 1645 3397993 SGTC_1147 3809-1045 12.3 µM 0.40434806461702 0.337731139528911 no 1115 0.342978392733536 1580 325925 SGTC_717 1532-0246 73.2 µM 0.403717869452542 0.337975606292865 no 1116 0.343210098817729 1603 9561992 SGTC_1061 3448-9325 110 µM 0.401999071778359 0.338642713438936 no 1117 0.3438423546997 1634 723482 SGTC_623 k072-0108 16.9 µM 0.400218371529308 0.339334380783949 no 1118 0.344497842188751 1641 5382803 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.400136184781741 0.339366317212737 no 1119 0.344528106967137 1723 23847180 SGTC_1524 corynanthine 62.1 µM 0.399492740855125 0.339616388882957 no 1120 0.344765085731452 1659 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1805 st050013 60.3 µM 0.399026761471507 0.339797533832717 no 1121 0.344936742796166 1669 4037144 SGTC_1758 st042942 75.2445 µM 0.398143689101263 0.340140921099245 no 1122 0.345262135738487 1648 669317 SGTC_578 3460-0051 92 µM 0.39678688372879 0.340668780274164 no 1123 0.345762311870265 1734 2876744 SGTC_1693 xanthone 101.9 µM 0.395577620859642 0.341139501851096 no 1124 0.34620832459429 1666 7020 An insecticide. SGTC_3229 9132204 49.47 µM 0.394203172621901 0.341674824338664 no 1125 0.34671552177043 1682 17682924 SGTC_687 k029-0044 34.9 µM 0.393541094298451 0.341932805515674 no 1126 0.346959939235295 1766 5829338 SGTC_2161 5662504 8.5105 µM 0.39191728290798 0.342565841753267 no 1127 0.347559666288981 1614 2859334 SGTC_1994 st072947 40.9 µM 0.391471192360305 0.342739825876245 no 1128 0.347724489133082 1692 5286565 YDL195W SEC31 SGTC_1457 k015-0032 57.3 µM 0.390934696026723 0.342949114228048 no 1129 0.347922753497298 1622 4302660 SGTC_2349 9023730 187.07 µM 0.390196915728476 0.343237002584003 no 1130 0.348195471063777 1736 4126287 SGTC_502 l-744,832 89.3 µM 0.389835772634563 0.343377956977581 no 1131 0.348328994811775 1735 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1167 k781-0610 148 µM 0.388025805002173 0.344084716447402 no 1132 0.348998468600031 1659 4525169 SGTC_2460 5552655 174.22 µM 0.387247175900079 0.344388924770539 no 1133 0.349286614005524 1592 5401989 SGTC_1879 gemcitabine 100 µM 0.385176330147406 0.345198488297206 no 1134 0.350053389409651 1684 60750 A nucleoside analog which inhibits DNA replication. SGTC_2655 perillic acid 100 µM 0.384791032096076 0.345349192644264 no 1135 0.350196121936651 1626 5702197 An apoptosis inducer. SGTC_943 3253-1379 105 µM 0.384238425041897 0.345565380545664 no 1136 0.350400870528553 1733 668464 SGTC_2346 9031566 143.75 µM 0.38170467894206 0.346557262932455 no 1137 0.351340214559456 1738 4771086 SGTC_33 0986-0033 35.816 µM 0.381092259672119 0.346797164196408 no 1138 0.351567395361856 1663 2848082 SGTC_41 0478-0632 82.643 µM 0.380996993259198 0.346834488162417 no 1139 0.351602739808233 1780 3750424 SGTC_1025 k007-0731 70 µM 0.380932700935975 0.346859677780077 no 1140 0.351626593394972 1627 6256118 SGTC_1507 4075-3230 155 µM 0.380792351257096 0.346914668885634 no 1141 0.351678667632696 1714 659771 SGTC_832 4083-0019 164 µM 0.380693116245974 0.346953552594863 no 1142 0.351715488688072 1792 1990758 SGTC_512 prima-1 270 µM 0.380473783660979 0.347039500404209 no 1143 0.351796876767236 1722 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1336 1486-0901 104 µM 0.380173195187557 0.347157301980615 no 1144 0.351908427625699 1689 5006114 SGTC_1084 voriconazole 435 nM 0.379448639610105 0.347441318301653 no 1145 0.352177368552326 1761 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1977 st070720 65.3 µM 0.379108406665443 0.347574714741784 no 1146 0.352303681921715 1643 682188 SGTC_630 4356-0227 183 µM 0.378582831530713 0.347780816105529 no 1147 0.352498836628683 1666 779312 SGTC_1605 st000082 49.1 µM 0.374991506530981 0.349190335462677 no 1148 0.353833391672025 1724 1114022 SGTC_1446 4239-0190 62 µM 0.372813999020555 0.350045976912596 no 1149 0.354643441547483 1652 1340085 SGTC_1942 st076330 65.2 µM 0.368499662688985 0.351743522125236 no 1150 0.356250348305041 1708 24208414 SGTC_2663 amphotericin b 100 µM 0.367961892753557 0.351955324544724 no 1151 0.356450824466244 1686 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2957 9076800 11.52 µM 0.367410618323602 0.352172493443415 no 1152 0.356656376171166 1620 16459615 SGTC_1187 1391-0724 117 µM 0.366980451043552 0.352341986920648 no 1153 0.356816800014915 1708 6997986 SGTC_1629 st005085 44.9 µM 0.36686180478159 0.352388740797144 no 1154 0.356861051652878 1600 24207091 SGTC_1273 0849-0096 14.1 µM 0.366629467312072 0.35248030241616 no 1155 0.356947712414839 1647 5286025 SGTC_405 ebelactone b 50 µM 0.36622926490234 0.35263803778798 no 1156 0.357097003301808 1653 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1217 1183-1422 255 µM 0.365943975587033 0.352750496901381 no 1157 0.35720344054694 1766 2849664 SGTC_2643 anethole 100 µM 0.365596254641156 0.352887583539881 no 1158 0.357333185140404 1687 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_295 k015-0027 31 µM 0.363963648987752 0.353531482421451 no 1159 0.357942577142187 1686 3887424 SGTC_61 0978-8327 98.565 µM 0.359729838628233 0.355203245174069 no 1160 0.359524587895326 1707 6150059 YHR072W ERG7 SGTC_1252 0493-0875 34.8 µM 0.359265355466497 0.355386821489667 no 1161 0.359698294466848 1648 3960963 SGTC_497 capsazepine 133 µM 0.35871655498051 0.355603765541736 no 1162 0.359903571236584 1602 2733484 A calcium channel blocker. SGTC_642 0335-0876 158 µM 0.358487696496346 0.355694248470471 no 1163 0.35998918684108 1699 6812350 SGTC_3097 9117246 49.47 µM 0.357791361075236 0.355969606011189 no 1164 0.360249728028885 1662 16423892 SGTC_297 0986-0032 24 µM 0.357728054251049 0.355994643668754 no 1165 0.360273418160949 1679 2847425 SGTC_1985 st071382 65.5 µM 0.35703344040866 0.356269402113159 no 1166 0.360533385763757 1701 6123237 SGTC_1552 6-methylflavone 10.6 µM 0.356369772652163 0.3565319893847 no 1167 0.360781831657462 1805 689013 SGTC_2358 9037157 4 µM 0.355233987232196 0.356981532837246 no 1168 0.361207152420804 1725 2388925 SGTC_1223 0764-0573 147 µM 0.353406600895777 0.357705228387457 no 1169 0.361891818951486 1688 1609797 SGTC_1295 1013-0063 9.78 µM 0.353114947215085 0.357820778746202 no 1170 0.362001133768611 1823 6826038 SGTC_1377 2944-0135 198 µM 0.352042849374399 0.358245645418391 no 1171 0.362403063827998 1731 1894137 SGTC_477 mead ethanolamide 10 µM 0.350154730756478 0.358994323417509 no 1172 0.36311128917402 1693 16061185 SGTC_2001 4023502 57.655 µM 0.348603849680537 0.359609685325564 no 1173 0.363693368605776 1737 108941 YCR052W RSC6 SGTC_2351 9026858 72.31 µM 0.34464909089857 0.361180508167396 no 1174 0.365179097585402 1636 1409300 SGTC_711 k292-0785 179 µM 0.343775235180329 0.361527919110567 no 1175 0.365507662922058 1666 4146315 SGTC_486 niguldipine 82 µM 0.343481876588245 0.361644572658715 no 1176 0.365617986415111 1730 1236 A calcium channel blocker. SGTC_1614 st002383 48.6 µM 0.34111116289448 0.362587753980602 no 1177 0.366509948951155 1724 1947235 SGTC_2107 5363541 170.161 µM 0.340573500247909 0.362801777744981 no 1178 0.366712340872266 1735 244052 SGTC_2032 5185112 25.99 µM 0.33856209568755 0.363602823732788 no 1179 0.367469820555503 1750 5718189 SGTC_2526 patulin 37.61 µM 0.336822886632296 0.364295948493172 no 1180 0.36812520956617 1760 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2851 9015922 71.43 µM 0.336345846877836 0.36448614023206 no 1181 0.368305040431215 1801 2996893 SGTC_3016 9080866 49.47 µM 0.335959283462298 0.364640284291656 no 1182 0.368450785372831 1672 17066299 SGTC_2940 9060638 45.86 µM 0.335268791689115 0.36491567572608 no 1183 0.3687111666784 1737 4027022 SGTC_778 3456-2434 196 µM 0.332561437685698 0.365996131145299 no 1184 0.369732678102586 1875 5539063 SGTC_2873 9040596 71.43 µM 0.332261640484943 0.366115840280885 no 1185 0.369845851258196 1680 6463863 SGTC_2479 5617353 43.85 µM 0.331970960545608 0.366231921335045 no 1186 0.369955593421253 1782 2731746 SGTC_64 000l-0018 272.079 µM 0.331794880289697 0.366302243740786 no 1187 0.370022075220842 1699 6811119 SGTC_2871 9038510 12.99 µM 0.331445757249974 0.366441688730835 no 1188 0.370153903459606 1877 4945164 SGTC_927 2425-1185 123 µM 0.331002190805819 0.366618881269895 no 1189 0.370321415361907 1668 730375 SGTC_2937 9044753 11.33 µM 0.329266054034472 0.367312693040866 no 1190 0.370977299899021 1695 6465530 YGL099W LSG1 SGTC_1391 3442-0225 151 µM 0.328551841241075 0.367598239627538 no 1191 0.371247226978853 1739 5227075 SGTC_256 clotrimazole 625 nM 0.327482335431108 0.368025971367558 no 1192 0.371651550672909 1728 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2095 5432005 200 µM 0.325745126934111 0.368721088772627 no 1193 0.372308599202779 1722 783734 SGTC_2504 purpurogallin 52.29 µM 0.325607444442572 0.368776198723539 no 1194 0.372360689525798 1712 5281571 An antioxidant. SGTC_272 doxorubicin 8.13 µM 0.324700064675279 0.36913946161903 no 1195 0.37270404285237 1742 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_14 0354-0009 295 µM 0.32465058234731 0.369159274873582 no 1196 0.372722769921588 1784 1713507 SGTC_2162 5663267 200 µM 0.323720983520131 0.369531560762599 no 1197 0.373074641525732 1836 6456493 SGTC_2893 9048488 25.97 µM 0.323714706078721 0.369534075169651 no 1198 0.373077018022184 1660 6467338 SGTC_978 1416-0512 87.4 µM 0.323676499009858 0.369549378996868 no 1199 0.373091482453055 1768 6814003 SGTC_1292 0kpi-0043 232 µM 0.323511753765541 0.369615370009782 no 1200 0.373153853750542 1718 3333905 SGTC_119 0121-0043 24.815 µM 0.323315035064796 0.3696941734692 no 1201 0.373228334310174 1769 1092378 SGTC_1737 st035557 69.7 µM 0.321703589530471 0.370339907517209 no 1202 0.373838629125456 1682 5716916 SGTC_2417 cerulenin 830 nM 0.321296953291859 0.370502911511752 no 1203 0.373992682521755 1736 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_865 0488-0499 301 µM 0.319848776580502 0.371083615564005 no 1204 0.374541484955602 1864 9634651 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.319833992149391 0.371089545486249 no 1205 0.374547088990671 1745 4620898 SGTC_3213 9129884 49.47 µM 0.319615837793836 0.371177049087131 no 1206 0.374629783426604 1635 17190742 SGTC_3324 9138759 60.749 µM 0.31901861941072 0.371416632613105 no 1207 0.374856196831748 1770 45595710 SGTC_2830 7992007 71.43 µM 0.318603163801609 0.37158332854384 no 1208 0.375013727008658 1677 1952075 SGTC_2630 antimycin a 100 µM 0.317934405780325 0.371851709209085 no 1209 0.375267346792862 1694 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1798 st045719 60.953 µM 0.316989952028981 0.372230835965015 no 1210 0.375625613261494 1841 3980186 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.316105638296586 0.372585933362406 no 1211 0.375961163633329 1753 2346 DNA damaging agent; causes G2/M arrest. SGTC_2437 5741531 144.16 µM 0.314311219879388 0.373306817193935 no 1212 0.376642338747606 1884 2262990 SGTC_709 3807-1509 243 µM 0.313291904800172 0.373716511290768 no 1213 0.377029449915479 1774 1886677 YPL242C IQG1 SGTC_1505 k297-0037 20.6 µM 0.31144050658396 0.374461010006754 no 1214 0.377732882075517 1719 4089396 SGTC_888 0916-0002 6.97 µM 0.311164338781481 0.374572104965576 no 1215 0.377837845875192 1835 2802138 YIL048W NEO1 SGTC_596 1155-0152 116 µM 0.310481069215783 0.37484701086346 no 1216 0.378097576629262 1739 280313 SGTC_399 oxolinic acid 75 µM 0.310432444659153 0.374866576838036 no 1217 0.378116062347586 1757 4628 A DNA gyrase inhibitor. SGTC_1163 k060-0048 49.9 µM 0.309919622428752 0.375072950336786 no 1218 0.378311040229624 1753 6809982 SGTC_2683 piperine 63.03 µM 0.309648777386824 0.375181960126211 no 1219 0.378414029539487 1773 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3203 9113543 49.47 µM 0.308622138211817 0.375595252602583 no 1220 0.378804489281603 1810 17018012 SGTC_2229 7354935 190 µM 0.30840039311915 0.375684538935223 no 1221 0.378888841436465 1836 318112 SGTC_2160 5660466 132.927 µM 0.308324313733349 0.375715174064336 no 1222 0.378917783474492 1889 2859134 SGTC_1996 st072960 66.8 µM 0.307511998283156 0.376042320527871 no 1223 0.379226845935819 1891 1719405 SGTC_21 0849-0113 22.993 µM 0.307329917828024 0.376115662618915 no 1224 0.379296132866184 1737 1560156 SGTC_2729 fluphenazine 10.66 µM 0.306723316660319 0.376360034118241 no 1225 0.379526990288675 1720 3372 An atypical antipsychotic. SGTC_720 r052-1644 49.9 µM 0.305821493009877 0.376723428675224 no 1226 0.379870281477686 1772 1422863 YOR257W CDC31 SGTC_1287 0971-0001 34.6 µM 0.30543167837252 0.376880540361235 no 1227 0.380018698939856 1807 4665869 SGTC_580 1123-0028 41 µM 0.305091345619517 0.377017725440657 no 1228 0.380148291190975 1811 1677248 YPR107C YTH1 SGTC_785 1270-0111 65.3 µM 0.304914646005298 0.377088957594096 no 1229 0.380215580357308 1746 6741994 SGTC_1936 st074407 74.3 µM 0.304731219921335 0.377162905785166 no 1230 0.380285434872819 1701 809813 SGTC_707 0865-0008 204 µM 0.304414543352688 0.377290584485335 no 1231 0.380406044620521 1832 723043 SGTC_15 0266-0086 27.098 µM 0.300066603445982 0.379044952119666 no 1232 0.382063176322076 1880 1712902 YIL048W NEO1 SGTC_2800 7887935 81.82 µM 0.299915830888712 0.37910583289692 no 1233 0.382120679289784 1816 2961002 SGTC_79 0052-0007 94.094 µM 0.299661498012867 0.379208537314674 no 1234 0.382217684897323 1885 2801472 SGTC_1195 1502-0147 41.1 µM 0.298145223613733 0.379821014261414 no 1235 0.382796163363214 1758 817940 SGTC_1766 st045414 44.774 µM 0.297956526809904 0.37989725671843 no 1236 0.382868171982037 1781 253960 SGTC_3302 9125395 16.351 µM 0.297762540718514 0.379975641165045 no 1237 0.382942203267254 1789 17599668 SGTC_1578 josamycin 24.2 µM 0.297412306178012 0.380117173800266 no 1238 0.383075874777016 1715 5282165 A P450 substrate. SGTC_208 k072-0098 12.366 µM 0.296986410954245 0.380289303165859 no 1239 0.383238441918201 1804 5948901 SGTC_2391 6285546 200 µM 0.296854632747905 0.380342567311598 no 1240 0.383288746734418 1742 846083 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.296793713126013 0.380367191509925 no 1241 0.383312002765347 1742 16623 A steroid. SGTC_2903 5923464 63.88 µM 0.296319738756467 0.38055879229266 no 1242 0.383492956567136 1910 2876576 SGTC_2151 5563267 85.4165 µM 0.295876832764213 0.380737860389614 no 1243 0.38366207206526 1785 5310824 SGTC_299 1273-0059 1.44 µM 0.294735348752889 0.38119948317862 no 1244 0.384098028811592 1859 2848077 SGTC_1459 k035-0031 35.7 µM 0.293688645974118 0.38162292452534 no 1245 0.384497915555605 1703 3877128 YMR208W ERG12 SGTC_2508 celastrol 40.54 µM 0.293167656311835 0.381833742619783 no 1246 0.384697002496057 1824 122724 Celastrol is a natural product and antioxidant. SGTC_1413 3910-0535 34.4 µM 0.293102169309421 0.381860244369491 no 1247 0.384722029342705 1879 2876951 SGTC_246 cycloheximide 667 µM 0.293016132915637 0.381895063035776 no 1248 0.384754910179629 1763 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2845 9003024 42.97 µM 0.292444885139559 0.382126269487878 no 1249 0.384973247002188 1866 2990173 SGTC_1859 st055998 20 µM 0.292266237274666 0.382198583941495 no 1250 0.385041535559138 1935 676301 SGTC_2290 7904846 200 µM 0.291926424938683 0.382336147126808 no 1251 0.385171439445497 1744 2962154 SGTC_2738 aclarubicin 5.55 µM 0.291512147499094 0.382503875441961 no 1252 0.385329827376385 1853 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1144 3486-0183 12.5 µM 0.289549699538852 0.383298709888244 no 1253 0.386080376529944 1805 6744069 SGTC_2826 7992541 19.48 µM 0.288443432139365 0.38374698927997 no 1254 0.386503662853151 1844 2985066 SGTC_570 0987-0065 62.6 µM 0.288293227479981 0.383807866914715 no 1255 0.386561145440841 1913 3104428 SGTC_3344 9148862 3.898 µM 0.287913836002395 0.383961646254479 no 1256 0.386706347783049 1897 4905352 SGTC_2600 tangeritin 87.95 µM 0.287837612523145 0.383992544241404 no 1257 0.386735522275816 1726 68077 A bioactive flavone. SGTC_138 0850-0259 40.9225 µM 0.285578786280079 0.384908517065479 no 1258 0.387600376591652 1849 6813004 SGTC_1680 diphenhydramine 100 µM 0.285062677170875 0.385117893983003 no 1259 0.387798061757102 1781 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1313 1220-0047 237 µM 0.284788140343574 0.385229282679175 no 1260 0.387903229395477 1853 3528706 SGTC_484 loperamide 105 µM 0.284352078940705 0.385406226715656 no 1261 0.388070289633076 1825 3955 An opioid-receptor agonist. SGTC_3269 9137823 49.47 µM 0.281785275676019 0.386448260865435 no 1262 0.389054080965481 1773 17682936 SGTC_2117 5521686 200 µM 0.279999772556883 0.387173597666964 no 1263 0.389738839692816 1765 803312 SGTC_2374 9071832 200 µM 0.279281067116729 0.387465673550609 no 1264 0.390014567358109 1879 17381698 SGTC_3147 9097027 49.47 µM 0.27871771796614 0.387694658483727 no 1265 0.390230732080542 1854 25236841 SGTC_1878 temozolomide 1 mM 0.27855019244111 0.387762760243491 no 1266 0.39029502045113 1980 5394 DNA alkylating agent. SGTC_2440 5628896 157.78 µM 0.278100396947254 0.387945626258437 no 1267 0.390467645517388 1811 5522048 SGTC_650 1328-0195 38 µM 0.2777183996366 0.388100948189333 no 1268 0.390614267571104 1918 2780821 SGTC_2757 clomiphene 4.22 µM 0.277254596379613 0.388289556868839 no 1269 0.390792310114117 1946 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2378 9074213 121.43 µM 0.276807875743229 0.388471243697458 no 1270 0.390963816710878 1786 657714 SGTC_2688 kanamycin b 96.69 µM 0.275878884646492 0.38884915401384 no 1271 0.391320546198485 1790 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_424 splitomicin 100 mM 0.27581237626531 0.388876213429341 no 1272 0.391346088706192 1739 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2739 tacrine 100.86 µM 0.274700501417845 0.389328667490757 no 1273 0.391773172950342 1819 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_311 1315-0136 58 µM 0.273682279007921 0.389743143337805 no 1274 0.392164398645213 1907 6759207 SGTC_1421 4029-0249 71.4 µM 0.273490328275579 0.389821292534229 no 1275 0.392238162989073 1957 2894095 SGTC_636 0kpi-0074 126 µM 0.272662943229269 0.390158198021123 no 1276 0.39255616133989 1824 616434 SGTC_2353 9059630 146.67 µM 0.272355061822325 0.390283586287136 no 1277 0.392674511247031 1903 4779114 SGTC_139 0099-0334 718.624 µM 0.272339375544291 0.390289975011089 no 1278 0.392680541333091 1961 97690 SGTC_1838 st055369 84.5 µM 0.27159204773569 0.390594381773655 no 1279 0.392967857344033 1838 676036 SGTC_308 4092-1169 104 µM 0.269057112179544 0.391627427910799 no 1280 0.393942866657683 1855 2268590 YDL196W YDL196W SGTC_95 0471-0001 561.058 µM 0.268686247737668 0.391778628228569 no 1281 0.394085567736059 1736 4015405 SGTC_1834 st055981 52.8 µM 0.267757021789194 0.392157542601501 no 1282 0.394443177353319 1937 471719 YDL150W RPC53 SGTC_3196 9111891 49.47 µM 0.267542707186395 0.392244949097308 no 1283 0.394525668277887 1859 18891510 SGTC_2708 st078559 56 µM 0.26537865907101 0.393127842721117 no 1284 0.39535888727714 1896 17250902 SGTC_2560 caryophyllene 100 µM 0.262071551528567 0.394478145623415 no 1285 0.396633139519913 1811 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1294 1000-1494 117 µM 0.261058074795634 0.394892206289762 no 1286 0.397023861148728 1801 712797 YDL207W GLE1 SGTC_755 1995-0008 37.3 µM 0.26070500388107 0.395036482978434 no 1287 0.397160003467624 1953 689533 SGTC_2328 6201408 200 µM 0.26047098530231 0.39513211879831 no 1288 0.397250246728422 1810 2890418 SGTC_691 1548-0686 185 µM 0.258384530004745 0.395985064174349 no 1289 0.398055077305567 1789 46495133 SGTC_1190 1486-1332 13 µM 0.258213422186125 0.396055035412504 no 1290 0.398121099843078 1861 4150046 SGTC_2518 prenyletin 46.28 µM 0.257818104035699 0.396216705939718 no 1291 0.398273645856598 1967 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1957 st077035 62.4 µM 0.257241266010854 0.396452643412582 no 1292 0.398496264946094 1923 705593 SGTC_9 0092-0002 10.449 µM 0.257162685560383 0.396484787214123 no 1293 0.398526594056329 1880 759368 SGTC_2572 astragaloside iv 100 µM 0.256720618790632 0.396665630367043 no 1294 0.398697226686916 1846 45006101 An anti-inflammatory agent. SGTC_2822 7994718 71.43 µM 0.256296278762544 0.396839242675945 no 1295 0.39886103521835 1892 1018011 SGTC_740 k014-0057 261 µM 0.254916850980947 0.397403755823156 no 1296 0.399393660465494 1964 4012779 SGTC_2449 5812982 45.77 µM 0.254482155805457 0.397581693854144 no 1297 0.399561544014835 1874 776185 SGTC_1430 4049-0248 69.1 µM 0.252883262743028 0.398236367497237 no 1298 0.400179211795673 1969 22774488 SGTC_1297 1068-0111 14.1 µM 0.252814143127875 0.398264675295912 no 1299 0.400205919011645 1795 767057 SGTC_207 4185-0010 4.486 µM 0.252720855975167 0.398302881709687 no 1300 0.400241965093148 1966 3761753 SGTC_389 tpck 16.7 µM 0.251789516446018 0.398684371803982 no 1301 0.40060188049077 1853 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1334 1486-0610 236 µM 0.248884197961797 0.399875052703401 no 1302 0.401725179481876 1904 3742339 SGTC_1056 3448-1962 115 µM 0.247880925313421 0.40028643889002 no 1303 0.402113269400917 1887 715507 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.24787392667626 0.400289309030173 no 1304 0.402115976981051 1846 688803 SGTC_420 mitomycin C 81.9 mM 0.247362107692589 0.400499220513198 no 1305 0.402313998385938 1854 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3065 9113888 49.47 µM 0.246538693608964 0.400836986275504 no 1306 0.402632627700405 1932 16648368 SGTC_1780 st038448 24.544 µM 0.246208998795626 0.400972248412426 no 1307 0.402760224953727 1945 728868 YDL195W SEC31 SGTC_1015 4130-4525 82 µM 0.244983044327602 0.401475318255201 no 1308 0.403234780029367 1809 1363237 SGTC_1366 1683-0113 21.9 µM 0.244897739060111 0.401510329319845 no 1309 0.403267806182735 1834 708623 SGTC_2774 tamoxifen 10.92 µM 0.244177087484679 0.401806131314356 no 1310 0.403546835802958 1904 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2475 5812728 15.03 µM 0.243637375022281 0.402027701056504 no 1311 0.403755839639269 1876 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.24361888689921 0.402035291598175 no 1312 0.403762999658475 1838 2724 A muscle relaxant with antifungal properties. SGTC_2387 9077560 195.08 µM 0.243434188845226 0.402111123837162 no 1313 0.403834530680437 1846 5303272 SGTC_2719 novobiocin 32.65 µM 0.24247441259798 0.402505242378101 no 1314 0.404206290580543 1973 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_905 2-aminofluorene 215 µM 0.242280899064262 0.402584717992969 no 1315 0.404281256638687 1847 1539 An established DNA mutagen. YPR165W RHO1 SGTC_3106 9121286 49.47 µM 0.241704514903107 0.402821461639227 no 1316 0.404504565446848 1980 15943471 SGTC_1010 4112-3296 15.2 µM 0.241589748881191 0.402868604815412 no 1317 0.404549033021401 2042 704384 SGTC_1130 3454-2858 15.9 µM 0.240392300337448 0.403360572558195 no 1318 0.405013073335449 1790 715628 YIL048W NEO1 SGTC_767 0929-0023 86 µM 0.239611844101885 0.403681302798266 no 1319 0.405315590982043 1883 1204563 SGTC_627 1391-0720 175 µM 0.238781840958913 0.404022465527769 no 1320 0.405637375898965 1903 997839 SGTC_445 e6 berbamine 66 µM 0.238132150554176 0.404289563852766 no 1321 0.405889299665958 1877 6610268 A calcium/calmodulin antagonist. SGTC_2100 5377183 190 µM 0.237058171770097 0.404731191840178 no 1322 0.40630583080062 1952 2844202 SGTC_2709 st078560 56 µM 0.236513088482078 0.404955380576679 no 1323 0.406517276102023 1988 17250903 SGTC_2187 6125751 200 µM 0.235854507210098 0.405226291809319 no 1324 0.406772785192961 1916 874498 SGTC_126 0417-1624 672.48 µM 0.235624966705993 0.405320725309441 no 1325 0.406861849116625 2032 41912 YDL195W SEC31 SGTC_215 1287-0124 461.5 µM 0.235563521905968 0.40534600477931 no 1326 0.406885691107626 2018 5560863 SGTC_2802 7925815 54.55 µM 0.234966838577457 0.405591511300564 no 1327 0.407117235851963 1856 1262923 SGTC_2150 5556613 200 µM 0.234181955924785 0.405914509351846 no 1328 0.407421861332124 1919 743190 SGTC_738 1315-0003 72.4 µM 0.233712376024358 0.406107783393236 no 1329 0.40760413956759 1989 6251474 SGTC_1345 1488-0192 31.4 µM 0.233622482472719 0.40614478522429 no 1330 0.407639036099201 1996 658348 SGTC_217 ketoconazole 989 nM 0.23319603739005 0.406320329240905 no 1331 0.407804591372081 1934 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2598 perillyl alcohol 100 µM 0.227736967706747 0.408569180135247 no 1332 0.409925365706734 1954 10819 An apoptosis inducer. SGTC_2684 capsaicin 100 µM 0.227713374991902 0.408578905692564 no 1333 0.409934536924362 1930 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1803 st050068 52.4 µM 0.225865677352121 0.409340751206829 no 1334 0.410652946762387 1950 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1281 0884-0031 11.8 µM 0.224770757868838 0.409792371898645 no 1335 0.411078807922571 1869 1548255 SGTC_1666 st014829 29 µM 0.224200826138067 0.410027498660936 no 1336 0.411300520334791 1889 3858230 SGTC_1989 st071868 50.2 µM 0.223186288309517 0.410446128786277 no 1337 0.411695261577594 2020 16414057 SGTC_2514 salinomycin 42.74 µM 0.221387240265719 0.411188723092259 no 1338 0.412395463374814 2043 23682228 A polyether potassium ionophore. SGTC_768 0384-0033 77.3 µM 0.220384083338246 0.411602935287428 no 1339 0.412786020178599 1845 3965305 YMR134W ERG29 SGTC_1227 3909-8010 46.6 µM 0.219684484334848 0.411891864133005 no 1340 0.413058444599998 1928 15982272 SGTC_1793 st048256 72.231 µM 0.219176343637165 0.412101752175719 no 1341 0.413256341260232 1977 672022 SGTC_3021 9087658 49.47 µM 0.218865232857346 0.412230269220746 no 1342 0.413377515009996 2041 25237042 SGTC_3125 9127534 49.47 µM 0.218555534168926 0.412358212292276 no 1343 0.413498146962946 2062 1639235 SGTC_1912 st060209 90.8 µM 0.217633799773664 0.412739055307371 no 1344 0.413857223621296 1863 688787 SGTC_160 3453-0671 289.699 µM 0.214117774316323 0.414192561201378 no 1345 0.415227607656473 1923 5322268 SGTC_2040 5100729 123 µM 0.213988627017462 0.414245972508862 no 1346 0.415277963047494 1959 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2706 st078239 82.5 µM 0.213194809177155 0.414574305684405 no 1347 0.415587508440004 1996 15434492 SGTC_573 3702-0553 84.7 µM 0.21261721092005 0.414813245218236 no 1348 0.415812773001214 1918 1222756 SGTC_2471 5466956 24.79 µM 0.210744887676796 0.415587999887429 no 1349 0.416543172913192 1970 724419 SGTC_1906 st060206 94.7 µM 0.209486588893487 0.416108860021687 no 1350 0.417034201824059 2033 5133468 SGTC_561 1550-0330 72.9 µM 0.209438073001433 0.416128945644115 no 1351 0.417053136891975 1892 6812934 SGTC_764 1951-2361 146 µM 0.209078037118119 0.416278007660879 no 1352 0.417193659824628 1842 5438930 SGTC_251 melphalan 456.522 µM 0.207878020164269 0.416774925392495 no 1353 0.417662105822524 1991 460612 A DNA alkylator. SGTC_787 4152-0075 138 µM 0.207827583046392 0.416795813930771 no 1354 0.417681797329857 1921 9566539 SGTC_1866 st057638 64 µM 0.207738356343229 0.416832767755694 no 1355 0.417716633455546 1922 688802 SGTC_3072 9116419 49.47 µM 0.207470221000028 0.416943822189657 no 1356 0.417821323450965 1921 17170162 SGTC_441 propafenone 146 µM 0.207171194975886 0.417067678528104 no 1357 0.417938081184224 1960 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2098 5376439 882.5 nM 0.206963814103958 0.417153580352659 no 1358 0.418019059389919 2020 2844116 SGTC_1849 st056239 19.2 µM 0.206534767404135 0.417331313702748 no 1359 0.418186604829447 1839 5393181 SGTC_357 1325-0123 420 µM 0.204956961008257 0.417985067796641 no 1360 0.418802875638159 2058 1098503 SGTC_283 0987-0079 11.7 µM 0.204567193319626 0.41814660055782 no 1361 0.418955144623621 2035 411556 SGTC_3154 9100113 49.47 µM 0.204076760916433 0.418349871756657 no 1362 0.419146757138184 1895 25237525 SGTC_339 3091-4833 71.4 µM 0.203862999396257 0.41843847705391 no 1363 0.419230280018567 1988 3240077 SGTC_846 0335-0850 148 µM 0.2037536644272 0.418483798585422 no 1364 0.419273001797212 2027 6819598 SGTC_358 0075-0058 9.45 µM 0.203408892619711 0.418626720479317 no 1365 0.419407724897652 2159 1069125 SGTC_2687 chenodiol 100 µM 0.201307770027237 0.419497952533922 no 1366 0.42022896366482 1964 5702181 A cholesterol synthesis inhibitor. SGTC_2914 7968218 45.32 µM 0.201186361776928 0.419548306661469 no 1367 0.42027642759754 2017 2977111 SGTC_2446 5162541 200 µM 0.201118781362919 0.419576336240015 no 1368 0.420302848316081 1914 1549321 SGTC_1369 1866-0067 208 µM 0.200331971378434 0.41990270268348 no 1369 0.420610479890526 2048 3531355 SGTC_532 1548-0774 215 µM 0.196858249820649 0.421344247648694 no 1370 0.421969233056009 2061 5932993 SGTC_2785 7756463 72.73 µM 0.196796883306203 0.42136972341749 no 1371 0.421993245092864 1923 2201551 SGTC_375 3970-0961 9.27 µM 0.196657820871323 0.421427455182344 no 1372 0.422047659755134 1980 2898222 SGTC_366 0181-0206 4.31 µM 0.196588049678494 0.421456421326964 no 1373 0.422074961548515 2084 274874 SGTC_175 3793-3120 23.7 µM 0.195755701695211 0.421802010893169 no 1374 0.422400692044214 1935 5322297 SGTC_2750 bromebric acid 70.15 µM 0.195313784800627 0.421985518584378 no 1375 0.422573653087212 1960 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1241 0364-0022 50.8 µM 0.194438287989495 0.422349121990996 no 1376 0.422916356233826 1984 4563895 SGTC_1417 3966-0327 90.4 µM 0.194217124908398 0.422440983922273 no 1377 0.423002937216253 1968 651118 SGTC_16 erodoxin 22.806 µM 0.193770564391495 0.422626479413172 no 1378 0.423177768179047 2024 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_2595 hexamethylquercetagetin 100 µM 0.19372338091002 0.422646079827073 no 1379 0.42319624166264 1961 386331 SGTC_2266 7929956 200 µM 0.193033215559709 0.422932802166206 no 1380 0.423466477505984 2056 2967153 SGTC_2485 5633444 17.78 µM 0.190911933392069 0.423814322730606 no 1381 0.424297295318894 1900 5724239 SGTC_2076 5212012 200 µM 0.190523473463672 0.423975792683363 no 1382 0.424449475445031 2028 604802 SGTC_250 brefeldin a 552.239 µM 0.189360188715337 0.424459407942116 no 1383 0.424905262367442 1973 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2569 tetrandrine 100 µM 0.189329032516892 0.424472362153196 no 1384 0.424917471069592 1889 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_608 k048-0125 159 µM 0.187894418418758 0.425068938148697 no 1385 0.425479709134628 2071 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2428 5615643 7.78 µM 0.187680792189702 0.425157788098477 no 1386 0.425563444152813 2021 2253075 SGTC_801 0866-0028 10.1 µM 0.187443653593529 0.425256421602082 no 1387 0.425656399239253 1936 6849771 SGTC_2306 7482397 179.52 µM 0.186177981829878 0.425782933819717 no 1388 0.426152595016104 2052 891448 SGTC_1407 3909-7909 12.3 µM 0.185637442963752 0.426007835284427 no 1389 0.426364544329535 1974 4411780 SGTC_1385 3091-4834 14.1 µM 0.185584251500831 0.426029967905106 no 1390 0.426385402248559 2028 4072814 SGTC_2385 9074692 200 µM 0.185579923860053 0.42603176861845 no 1391 0.426387099251383 1931 17046906 SGTC_1763 st044482 94.5 µM 0.185356076132445 0.426124912829949 no 1392 0.426474878779499 2028 88505 SGTC_2242 6630449 61.2675 µM 0.185284511451132 0.426154692138228 no 1393 0.426502942883877 1996 691249 YDR170C SEC7 SGTC_2217 6934799 96.0675 µM 0.184993369989136 0.42627584550235 no 1394 0.426617117902531 2087 675606 SGTC_1570 verbenone 133 µM 0.184010474834991 0.426684911247526 no 1395 0.427002618754726 2090 29025 A natural terpanoid with antifungal properties. SGTC_1322 1348-1070 12 µM 0.183898298447165 0.426731602345899 no 1396 0.427046619843649 2069 6758089 SGTC_262 fenpropimorph 62.5 µM 0.181667634073971 0.427660282561953 no 1397 0.427921783763075 2041 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2714 st079313 56.9 µM 0.178646525699285 0.428918682278713 no 1398 0.429107629933542 1981 2939799 SGTC_1949 st076024 69.1 µM 0.177716125960737 0.429306373241763 no 1399 0.429472960081471 1992 2921930 SGTC_3026 9090633 49.47 µM 0.177539290110768 0.429380067208833 no 1400 0.42954240317126 1987 25236842 SGTC_999 SEC7.066 22.7 µM 0.176547431022914 0.429793456717189 no 1401 0.429931944629773 2010 740511 YDR170C SEC7 SGTC_1916 st067606 49.2 µM 0.175887116545903 0.430068706948239 no 1402 0.430191313533567 2054 19590279 SGTC_2382 9035899 200 µM 0.175367734162742 0.430285233921215 no 1403 0.430395346042898 1960 6462679 SGTC_1346 1488-2224 62.4 µM 0.175262999736621 0.430328899531249 no 1404 0.430436491832291 2102 3722427 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.174698726362974 0.430564169595538 no 1405 0.430658184300208 2062 3256 An antibiotic and ribosome inhibitor. SGTC_185 k048-0037 25.491 µM 0.174633428692177 0.430591396621814 no 1406 0.430683839947473 2116 6827589 SGTC_1568 digitonin 820 nM 0.173699708601412 0.430980763866496 no 1407 0.431050733272896 2134 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2341 7987486 176.74 µM 0.173470123661834 0.431076512544716 no 1408 0.431140954855301 2111 1258686 SGTC_3262 9137218 49.47 µM 0.172569169621124 0.431452295611559 no 1409 0.431495043674031 2091 17650664 SGTC_3135 9127742 49.47 µM 0.172114745307759 0.431641857102006 no 1410 0.431673660335929 1948 3643468 SGTC_1076 itraconazole 331 nM 0.171543972026127 0.431879975451849 no 1411 0.431898029077301 2103 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_112 phenothiazine 287.218 µM 0.171486759784962 0.431903844936844 no 1412 0.43192052019783 2115 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2458 5808907 16.39 µM 0.170915416690826 0.432142228271837 no 1413 0.432145137133213 2118 2731747 SGTC_955 1216-0110 33 µM 0.170044451980391 0.432505671219059 no 1414 0.432487589027084 1996 3619719 SGTC_45 0kpi-0036 14.9 µM 0.169844864655327 0.432588964629393 no 1415 0.432566071296496 2020 2795021 SGTC_63 0099-0242 26.702 µM 0.168832301451463 0.433011581838321 no 1416 0.432964275070023 2134 3898502 YLR359W ADE13 SGTC_1959 st077091 55.8 µM 0.16705111132036 0.433755189346316 no 1417 0.433664916443103 2032 821356 YKL052C ASK1 SGTC_2262 9014885 67.46 µM 0.167029027976913 0.433764410131335 no 1418 0.433673604366174 2095 6457424 SGTC_398 bronopol 33.3 µM 0.16686017532333 0.433834914868391 no 1419 0.433740034626333 2021 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1240 0356-0016 42.1 µM 0.166273787863715 0.434079778369961 no 1420 0.433970746570667 2017 4305613 SGTC_1308 1187-1617 41.4 µM 0.165652702066313 0.434339158777591 no 1421 0.43421513497587 2003 2882570 SGTC_338 4055-0136 114 µM 0.165554954415535 0.43437998313139 no 1422 0.434253599575111 2027 2900563 SGTC_415 dibenzyl ketone 100 µM 0.165521098091002 0.434394123404954 no 1423 0.434266922495234 2096 7593 SGTC_2784 7567673 72.73 µM 0.164579676206856 0.43478734680165 no 1424 0.434637414546638 2087 3471247 SGTC_640 3381-0960 37.1 µM 0.164202941384978 0.434944723621511 no 1425 0.434785692823822 2096 1745025 SGTC_595 3909-8003 73.7 µM 0.163248214293099 0.435343596443684 no 1426 0.435161502911335 2074 699517 SGTC_2480 5767542 37.17 µM 0.161998339174785 0.435865877742011 no 1427 0.435653580870887 2058 2867358 SGTC_2985 9022375 71.43 µM 0.160806725355864 0.43636391776136 no 1428 0.436122814054541 2030 4939335 SGTC_1678 st019265 80.2 µM 0.159755620570607 0.436803315224919 no 1429 0.436536792314876 2144 5367020 SGTC_2058 5236698 133 µM 0.15957663295463 0.436878145906163 no 1430 0.436607293635961 2020 766665 SGTC_3042 9091578 49.47 µM 0.159276830036758 0.437003491796083 no 1431 0.436725387331589 2124 25236497 SGTC_2356 9061756 188.97 µM 0.159070493856157 0.43708976345119 no 1432 0.43680666734274 2129 20104043 SGTC_94 0334-0113 514.748 µM 0.15850729325199 0.437325259657555 no 1433 0.437028537065486 2031 6795178 SGTC_2366 9070441 60.58 µM 0.158450755647389 0.4373489014698 no 1434 0.437050810833214 2036 6837235 SGTC_838 0109-0203 71.4 µM 0.156840015440509 0.438022543600828 no 1435 0.437685467668369 2067 759422 SGTC_2727 riluzole 51.77 µM 0.156636644621291 0.438107609951016 no 1436 0.437765610386457 2159 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1049 3226-0134 66 µM 0.156234894472877 0.438275663202781 no 1437 0.437923936316916 2109 5702385 SGTC_1244 0416-0015 52.5 µM 0.15328955278343 0.439508046189162 no 1438 0.439084969489831 2025 96201 SGTC_2400 5203494 178.7 µM 0.152284908197497 0.43992854196932 no 1439 0.439481113801759 2114 6777674 SGTC_2130 NSC 7 2.4545 µM 0.151618094413476 0.440207675514333 no 1440 0.439744080563212 2118 21448 SGTC_1516 st013856 110 µM 0.151334985027205 0.440326196347185 no 1441 0.439855736509971 2061 5281404 A mutagen and neurotoxin. SGTC_2240 6690706 185.951 µM 0.149043181838437 0.441285832103811 no 1442 0.440759779647596 1934 805876 SGTC_940 3232-1287 54.8 µM 0.147044674915694 0.442122938974953 no 1443 0.441548379034326 2182 1585493 YIL048W NEO1 SGTC_1253 0550-0034 176 µM 0.1470141566487 0.442135724057003 no 1444 0.441560423172276 2035 5969915 SGTC_435 c-PAF 6.7 µM 0.146877133418073 0.442193128231078 no 1445 0.441614500522479 2154 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_559 1550-0661 158 µM 0.146188689639532 0.442481561515175 no 1446 0.441886216999111 2061 5830875 SGTC_2196 6573537 42.6665 µM 0.14532657164154 0.442842801058813 no 1447 0.442226518143015 2159 2903087 SGTC_2867 9039098 71.43 µM 0.145297336627882 0.44285505177466 no 1448 0.442238058737484 2094 6463460 SGTC_1196 1588-0294 184 µM 0.143473167818794 0.4436195637886 no 1449 0.44295825048727 2005 6144269 SGTC_1733 st037357 54.9 µM 0.142721438900896 0.443934675791804 no 1450 0.44325509212849 2060 1272339 YGL099W LSG1 SGTC_659 k018-0002 107 µM 0.142596130108359 0.443987206563171 no 1451 0.44330457698695 2170 6797879 YHR007C ERG11 SGTC_3238 9133470 49.47 µM 0.14243178079754 0.444056105024421 no 1452 0.443369480416029 2163 3534688 SGTC_516 3992-2719 87.3 µM 0.141369789894848 0.444501353155415 no 1453 0.443788909364605 2075 5350887 YDR037W KRS1 SGTC_672 1441-0018 53.7 µM 0.140674348410958 0.444792960514814 no 1454 0.444063605275577 2047 251141 SGTC_701 4424-0219 185 µM 0.14001610044569 0.445068999693242 no 1455 0.444323634692164 2166 2911779 SGTC_2146 5545642 200 µM 0.139325367931913 0.445358690049997 no 1456 0.444596522333142 2148 825326 SGTC_661 1304-0007 33.6 µM 0.139318166132165 0.445361710608965 no 1457 0.444599367686176 2041 3117130 SGTC_2880 9042983 58.44 µM 0.136804793461297 0.446416054922605 no 1458 0.445592547318452 2078 6464714 SGTC_1075 aripiprazole 15.2 µM 0.135148526599748 0.447111056245157 no 1459 0.446247221709292 2069 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2336 9001819 198.65 µM 0.13494335617755 0.447197161038483 no 1460 0.446328329881533 2131 2989602 SGTC_610 4215-0184 155 µM 0.134711339674394 0.447294535445757 no 1461 0.446420053578213 2094 5605015 SGTC_3286 9117135 37.221 µM 0.134343970225906 0.44744872227669 no 1462 0.446565292573604 2029 3438150 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.132504691006704 0.448220796101703 no 1463 0.447292556427947 2182 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3032 9089427 49.47 µM 0.132159841580514 0.448365575394975 no 1464 0.447428932107008 2068 17173707 SGTC_820 1582-0060 59.9 µM 0.131334777561453 0.448711992669716 no 1465 0.447755240767361 2061 3848840 SGTC_1055 3448-0672 86 µM 0.130508733802344 0.449058860481677 no 1466 0.448081972333475 2104 748378 SGTC_2265 7929201 200 µM 0.129601986137997 0.449439661859515 no 1467 0.448440665895786 2192 1265108 SGTC_1824 st053723 68.6 µM 0.128861199665517 0.449750800091948 no 1468 0.448733739405657 2032 675225 SGTC_2121 5257820 149.641 µM 0.127705018810956 0.450236470068843 no 1469 0.449191209090341 2192 791256 SGTC_517 1365-0151 113 µM 0.126996853575721 0.450533981658284 no 1470 0.449471444434595 2080 768657 SGTC_2057 5236571 38.335 µM 0.126976183821798 0.450542665772213 no 1471 0.449479624254611 2157 54684039 YBR257W POP4 SGTC_3017 9080681 49.47 µM 0.126744894689123 0.45063984034642 no 1472 0.449571155761523 2063 16451914 SGTC_3104 9120930 49.47 µM 0.126631063873155 0.450687666685329 no 1473 0.449616204717987 2090 17014836 SGTC_122 0236-0016 402.397 µM 0.125759974164539 0.451053681141606 no 1474 0.44996096307173 2180 6808838 SGTC_2145 5634607 200 µM 0.125357312734761 0.451222885498503 no 1475 0.450120340485002 2074 308662 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.125129814311109 0.451318487660021 no 1476 0.450210390190297 2186 165521 SGTC_1082 camptothecin 424.86 nM 0.124805541262579 0.451454762514032 no 1477 0.450338750201754 2112 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2214 7179297 48.276 µM 0.123447128287009 0.452025693817863 no 1478 0.450876519731609 2126 769744 SGTC_1423 4048-0112 5.59 µM 0.123242716992224 0.452111615047968 no 1479 0.450957450056273 2192 X1423 SGTC_2224 6650123 117.647 µM 0.123236676633733 0.452114154056444 no 1480 0.450959841580269 2143 2908370 SGTC_2783 7738165 71.43 µM 0.123205651261688 0.4521271953137 no 1481 0.450972125303383 2035 17201110 SGTC_2628 lathosterol 100 µM 0.122729981909426 0.452327145430559 no 1482 0.451160460604401 2112 6710616 SGTC_1479 0549-0158 134 µM 0.122689090553255 0.452344334892552 no 1483 0.451176651536714 2130 5440202 SGTC_594 1487-1584 10.8 µM 0.121339507880145 0.452911707658874 no 1484 0.451711064211666 2095 5013332 SGTC_2670 beta-carotene 100 µM 0.120345493014211 0.453329659109972 no 1485 0.452104733872554 2191 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_165 k038-0023 64.381 µM 0.119785791392911 0.453565018517383 no 1486 0.452326418859697 2136 46368543 SGTC_2071 5230951 39.92 µM 0.119432317067619 0.453713665958383 no 1487 0.452466429602143 2180 1799272 SGTC_1143 3454-2408 5.08 µM 0.119360580854426 0.453743834159533 no 1488 0.452494844949416 2188 X1143 SGTC_2177 5811945 192 µM 0.11886098530365 0.453953943234469 no 1489 0.452692745896815 2158 5343475 SGTC_2553 4-methylesculetin 85.09 µM 0.118462509827397 0.454121534660278 no 1490 0.452850599353183 2068 5319502 SGTC_1333 1482-0047 286 µM 0.118266080836302 0.454204152073823 no 1491 0.452928416158113 2224 3811116 SGTC_2284 7945075 39.21 µM 0.116352940735914 0.455008915851638 no 1492 0.453686414924699 2206 1245402 SGTC_1182 1222-0449 220 µM 0.116349617624485 0.455010313882511 no 1493 0.45368773171104 2142 658318 SGTC_2760 etidronate 98.04 µM 0.115782075991981 0.455249086447585 no 1494 0.453912628126635 2135 3305 A chelator and antioxidant. SGTC_2456 5770359 74.46 µM 0.114643403271636 0.455728190382272 no 1495 0.454363887828092 2184 3118787 SGTC_728 3030-5151 22.5 µM 0.114418474778784 0.455822838142498 no 1496 0.454453034707411 2161 3125388 SGTC_1947 st076332 61.6 µM 0.114198709913278 0.455915315519163 no 1497 0.454540137279986 2210 24208416 SGTC_220 paclitaxel 373.376 µM 0.113814756176669 0.456076889541308 no 1498 0.454692320434732 2191 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_900 1112-0045 141 µM 0.112571943872128 0.456599934991083 no 1499 0.455184964587691 2200 56211 YIL048W NEO1 SGTC_1426 4048-4480 71.7 µM 0.110105636513254 0.457638117933224 no 1500 0.456162799024301 2207 14224343 SGTC_3023 9089636 49.47 µM 0.110050333884876 0.45766140071031 no 1501 0.456184728317282 2236 17249241 SGTC_2036 5160441 105 µM 0.109964245581296 0.457697644752034 no 1502 0.456218865398522 2128 134534 YIL048W NEO1 SGTC_3162 9099653 49.47 µM 0.109240545184014 0.458002343778581 no 1503 0.456505851157296 2208 25237511 SGTC_1149 3909-7961 23.3 µM 0.108460572866087 0.458330762560578 no 1504 0.456815177130051 2054 735261 SGTC_2038 4100038 30.985 µM 0.108322538914629 0.458388886749129 no 1505 0.456869922170614 2139 3596803 SGTC_1389 3405-0187 19 µM 0.106879614288767 0.45899653539083 no 1506 0.457442242990621 2087 799890 SGTC_547 1120-0019 610 nM 0.105828046623864 0.459439435083395 no 1507 0.457859391875653 2159 3676939 SGTC_1108 betulinic acid 729.144 nM 0.105794366711612 0.459453621237347 no 1508 0.457872753210076 2148 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_141 0443-0274 32.331 µM 0.104941644530393 0.459812809400171 no 1509 0.458211056914844 2223 1627241 SGTC_1753 st043925 64 µM 0.103579630846843 0.46038659195116 no 1510 0.458751476465404 2210 670181 SGTC_1014 4130-3005 69.3 µM 0.103491547378945 0.460423702182284 no 1511 0.458786428843919 2151 743608 SGTC_2659 sanguinarine 24.21 µM 0.103487006288363 0.460425615387433 no 1512 0.458788230801558 2184 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2636 apigenin dimethyl ether 100 µM 0.103345271552061 0.460485330055704 no 1513 0.45884447322139 2145 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1707 st032323 6.317 µM 0.103292557213756 0.460507539512197 no 1514 0.458865391253352 2140 3132057 YMR211W DML1 SGTC_2908 7930301 100 µM 0.101964373126768 0.461067166764842 no 1515 0.459392476889769 2230 2223178 SGTC_361 000s-0510 1.45 µM 0.100611706139587 0.461637189079915 no 1516 0.459929351854218 2139 660 SGTC_1504 k297-0033 30 µM 0.100609571877392 0.461638088533915 no 1517 0.459930199003144 2140 4388117 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.100563037597399 0.461657699783392 no 1518 0.459948669817971 2186 364106 SGTC_3015 9080845 49.47 µM 0.0982649105703327 0.462626329701958 no 1519 0.460860970301989 2208 5296973 SGTC_1846 st056244 14.8 µM 0.0977041899167912 0.462862699845062 no 1520 0.461083594203092 2157 5393182 SGTC_74 000s-0487 160.283 µM 0.0966841389238745 0.463292732910919 no 1521 0.461488618059117 2253 677548 SGTC_2520 obtusaquinone 4.71 µM 0.0956872532350131 0.463713041399987 no 1522 0.461884482443923 2220 5967872 SGTC_2287 7945887 168.79 µM 0.0947424737607834 0.464111418178337 no 1523 0.462259690254674 2218 1245853 SGTC_734 2023-0417 80 µM 0.0938701142289281 0.46447929024368 no 1524 0.462606167186963 2198 3935732 SGTC_2568 diosmetin 100 µM 0.0931773656237688 0.464771442429582 no 1525 0.46288132788191 2255 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1000 4048-0884 8.67 µM 0.0914686987711121 0.465492117683121 no 1526 0.463560088355719 2165 13040088 SGTC_652 0437-0092 114 µM 0.0907394277788077 0.465799741536339 no 1527 0.463849820502429 2219 3091274 SGTC_2194 5927483 104.545 µM 0.0892618712846964 0.466423072472608 no 1528 0.464436897688092 2237 760979 SGTC_2092 5303694 80.6725 µM 0.0887609608318241 0.466634408363485 no 1529 0.464635941963339 2155 1963699 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0885882222752604 0.466707289555625 no 1530 0.464704584272186 2235 6710655 SGTC_2756 carbadox 75.1 µM 0.0882762507883605 0.466838918201007 no 1531 0.464828557188886 2165 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2654 protoveratrine a 100 µM 0.0862430345276051 0.46769687166389 no 1532 0.465636610759346 2231 5702278 A heart drug and vasodilator. SGTC_184 1494-0393 24.714 µM 0.0859027291060509 0.467840484643216 no 1533 0.465771871009907 2206 3090647 SGTC_3314 9135860 59.4275 µM 0.0851862193668026 0.4681428740297 no 1534 0.466056673054058 2241 25252478 SGTC_680 0417-1641 114 µM 0.0851753551742836 0.468147459198627 no 1535 0.466060991544364 2180 2835990 SGTC_903 1134-0042 114 µM 0.0848233836125526 0.468296009020778 no 1536 0.466200901549726 2148 701009 SGTC_2233 sulbentine 40.3845 µM 0.0838081929491813 0.468724495544318 no 1537 0.466604466954263 2223 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1622 st003707 19.4 µM 0.0837720245494216 0.468739761990277 no 1538 0.466618845495142 2183 10140899 SGTC_3141 9094609 49.47 µM 0.083535845317819 0.468839452834662 no 1539 0.466712738270809 2099 25236309 YDL196W YDL196W SGTC_715 0868-0130 184 µM 0.0827276640210106 0.469180599503066 no 1540 0.467034043777913 2262 2876258 SGTC_310 1273-0058 1.06 µM 0.0816333570058405 0.469642560577024 no 1541 0.467469137376945 2233 2734232 SGTC_2819 7996655 46.38 µM 0.0814356210908933 0.46972603905669 no 1542 0.467547760819498 2247 6456960 SGTC_614 0462-0418 107 µM 0.0814150640580663 0.46973471772773 no 1543 0.467555934747165 2224 5188303 SGTC_3340 9146634 11.102 µM 0.0812112576003472 0.469820760552826 no 1544 0.467636973409766 2172 4907387 SGTC_1455 4262-0120 131 µM 0.0807963431659921 0.469995933102205 no 1545 0.467801958147085 2230 1529587 SGTC_2742 clothiapine 36.27 µM 0.0807363253075117 0.470021272498006 no 1546 0.467825823840972 2263 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2026 5148700 152 µM 0.0802659054675195 0.470219886822215 no 1547 0.468012887094794 2230 79838 SGTC_1400 3771-8998 51.5 µM 0.0801255405247249 0.470279151253836 no 1548 0.468068704824423 2224 670767 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0801067901398333 0.470287068030501 no 1549 0.468076161177616 2171 75037 A free radical scavenger. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0795978583138425 0.470501953406897 no 1550 0.468278549315755 2248 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1073 triclabendazole 3.09 µM 0.0786302683797069 0.47091052081626 no 1551 0.468663355690978 2164 50248 An antihelmetic and likely tubulin inhibitor. SGTC_695 3505-6186 243 µM 0.0772990539263957 0.4714726795974 no 1552 0.469192821757222 2219 1819379 SGTC_1197 1601-0112 267 µM 0.0764536932572001 0.471829696681159 no 1553 0.469529076761202 2242 7350313 SGTC_2300 7976697 71.57 µM 0.0757850963373596 0.472112078031463 no 1554 0.469795036711389 2194 2236109 SGTC_916 4466-0038 42 nM 0.075212600031088 0.472353882514352 no 1555 0.470022779688261 2284 5722064 YGL116W CDC20 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.0738217391979996 0.47294138077663 no 1556 0.470576114420693 2261 140250 A respiratory chain inhibitor. SGTC_1042 0350-0096 82 µM 0.0727757138767026 0.473383259708041 no 1557 0.470992298608684 2193 3122515 SGTC_2278 7948257 134.34 µM 0.0726868392532289 0.473420805080976 no 1558 0.471027660799691 2290 1247028 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0719390280968017 0.473736729648596 no 1559 0.471325215282841 2266 688798 SGTC_2189 6047310 154.431 µM 0.0718059543765529 0.473792950468666 no 1560 0.471378167074104 2243 711535 SGTC_472 calcifediol 10 µM 0.0716614818947668 0.473853987614272 no 1561 0.471435655155988 2184 5283731 A vitamin D metabolite. SGTC_3208 9114115 49.47 µM 0.0713303116960544 0.473993903656862 no 1562 0.471567435709974 2121 650895 SGTC_1107 amlodipine 47 µM 0.0703184570026252 0.474421421780967 no 1563 0.471970096152985 2240 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2185 6113692 200 µM 0.0702263711123611 0.474460330405402 no 1564 0.472006742512479 2213 874150 SGTC_456 gingerol 170 µM 0.0696763052224096 0.47469275225736 no 1565 0.4722256508146 2232 442793 A herb. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.0696707343333007 0.474695106194761 no 1566 0.472227867889984 2264 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2056 5235370 200 µM 0.0692450442217417 0.474874980964581 no 1567 0.472397284512629 2223 5511916 SGTC_321 4534-3890 65.3 µM 0.0690914206313165 0.474939895660459 no 1568 0.472458425027404 2293 699746 SGTC_1158 4092-0494 91.8 µM 0.0682464541230406 0.475296953867916 no 1569 0.472794724051583 2233 1148199 SGTC_301 4119-0100 24.5 µM 0.0673616508785761 0.475670867178871 no 1570 0.473146898990326 2235 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1027 k015-0025 8.67 µM 0.067292222137847 0.475700208319327 no 1571 0.473174534345064 2292 3598955 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0672393559894661 0.475722550064324 no 1572 0.473195577226741 2266 165506 SGTC_443 clozapine 122 µM 0.0671480182531254 0.475761150453852 no 1573 0.473231933544605 2294 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_383 2324-0395 7.37 µM 0.0650421451337542 0.476651179270363 no 1574 0.474070222156322 2254 3146421 SGTC_2157 5649910 96.377 µM 0.0648726670984158 0.476722812800509 no 1575 0.474137691617378 2260 2858091 SGTC_883 0850-0245 24.6 µM 0.064735296483798 0.476780875992028 no 1576 0.474192379610299 2237 6823229 YPR165W RHO1 SGTC_1691 st019933 84.6 µM 0.0642502595387953 0.476985893154139 no 1577 0.474385479353803 2295 6176082 SGTC_2396 5342950 42.78 µM 0.0637083322790741 0.477214964122025 no 1578 0.474601235014028 2216 1886677 SGTC_706 4262-0057 46.9 µM 0.0632904475096945 0.477391607859963 no 1579 0.474767611148669 2285 883298 SGTC_1847 st056231 15 µM 0.0630531228621185 0.477491929152618 no 1580 0.474862101256692 2288 5393180 SGTC_2844 9010103 25.97 µM 0.0624297583904692 0.477755443029714 no 1581 0.475110298702271 2200 2480525 SGTC_964 1287-0107 19.4 µM 0.0612845714213931 0.478239571368044 no 1582 0.475566288963514 2269 51516812 YPR165W RHO1 SGTC_501 nsc-95397 161 µM 0.060945315626262 0.478382998115129 no 1583 0.475701379922876 2260 262093 SGTC_1929 genistein trimethyl ether 50.5 µM 0.0609302513114969 0.478389366901645 no 1584 0.475707378566892 2321 136420 SGTC_2865 9030313 51.95 µM 0.0608404105537362 0.478427349268647 no 1585 0.475743153472955 2285 42562754 SGTC_1740 st038286 13.222 µM 0.0608013312777897 0.478443871044884 no 1586 0.475758715039278 2258 716786 SGTC_3157 9099274 49.47 µM 0.0590224419950019 0.47919598134662 no 1587 0.476467116571203 2294 17217662 SGTC_3059 1327-0034 3 µM 0.0589489455886543 0.479227057070386 no 1588 0.47649638643134 2251 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_172 1112-0046 2.638 µM 0.0584051896043511 0.479456971688092 no 1589 0.476712940562219 2247 2802135 YIL048W NEO1 SGTC_2267 7931562 200 µM 0.0582500178327124 0.479522583732947 no 1590 0.476774739929025 2258 934880 SGTC_1687 st020778 55.3625 µM 0.0576110256221962 0.479792777785786 no 1591 0.47702923354252 2230 4259299 SGTC_42 0133-0086 60.653 µM 0.0575997325228415 0.479797553089496 no 1592 0.477033731368388 2310 162923 Model of phenazepam hydroxylation. SGTC_2388 9080168 200 µM 0.0575592127176134 0.479814686972731 no 1593 0.477049869657293 2312 15943073 SGTC_413 propylparaben 100 µM 0.0574380109911709 0.479865937595304 no 1594 0.47709814228757 2250 7175 A pharmaceutical preservative. SGTC_2296 7971656 126.45 µM 0.0566130958012875 0.480214764998212 no 1595 0.477426701168143 2254 666570 SGTC_2264 7948757 110.76 µM 0.056168883858411 0.480402612781731 no 1596 0.477603634549302 2312 2971411 SGTC_3061 glucosamine 200 µM 0.0535266278040787 0.481520055188479 no 1597 0.478656157568043 2306 91431 and experimental redox chemotherapeutic SGTC_70 0141-0289 43.283 µM 0.0533307256106776 0.481602910512564 no 1598 0.478734199765612 2191 352408 SGTC_843 0310-0051 143 µM 0.0532483940411483 0.481637732253248 no 1599 0.478766998705781 2216 2065037 SGTC_2381 9035592 200 µM 0.0532282426028405 0.481646255228348 no 1600 0.478775026581688 2158 4749657 SGTC_200 k038-0079 37.545 µM 0.0526998020227464 0.481869760168426 no 1601 0.478985548385565 2254 3436683 SGTC_2285 7945142 200 µM 0.0525538487096789 0.481931492404784 no 1602 0.47904369475669 2272 2970608 SGTC_1655 st012546 55.1 µM 0.0515687734372915 0.482348149903163 no 1603 0.479436150703437 2274 720985 YLR208W SEC13 SGTC_2399 5884133 200 µM 0.0514291596162518 0.482407203961331 no 1604 0.479491774749128 2269 722445 SGTC_429 1112-0049 25.5 µM 0.0505033670127938 0.482798806775123 no 1605 0.479860633171199 2229 2836170 SGTC_3267 9137951 49.47 µM 0.0502958824329674 0.482886573370857 no 1606 0.479943302480698 2223 16643986 SGTC_3183 9108214 49.47 µM 0.0499496099002978 0.483033049529153 no 1607 0.480081271815469 2305 4974831 SGTC_920 mycophenolic acid 780.421 nM 0.0498747200136895 0.483064728875283 no 1608 0.480111111365941 2272 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_153 4077-0274 519.67 µM 0.0496901471743937 0.483142805919876 no 1609 0.480184654088638 2328 3121976 SGTC_2075 5212009 200 µM 0.0494192631932553 0.483257395025484 no 1610 0.480292588554424 2309 780898 SGTC_2154 5570129 200 µM 0.0492688277126069 0.483321032709269 no 1611 0.480352530609132 2315 673366 SGTC_2965 9082772 38.63 µM 0.049121835545174 0.483383214202448 no 1612 0.480411101081094 2315 16459634 SGTC_1372 2752-0194 270 µM 0.0478896435166227 0.48390447908601 no 1613 0.480902096599159 2328 823334 SGTC_454 lyso-paf C-16 6.67 µM 0.0472881618724242 0.484158939131223 no 1614 0.481141781492956 2262 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_446 go6976 132 µM 0.0469379176528418 0.484307114811284 no 1615 0.481281353733953 2305 3501 A protein kinase C inhibitor. SGTC_1352 1496-0991 99 µM 0.0468602520281249 0.484339972626449 no 1616 0.481312303778969 2301 3000039 SGTC_100 0086-0128 49.5915 µM 0.0465388565787806 0.48447594577957 no 1617 0.481440382275828 2300 93297 SGTC_1588 farnesol 29.9 µM 0.0461048788175164 0.484659552126249 no 1618 0.481613328705714 2326 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2588 indole-3-carbinol 100 µM 0.045865268567247 0.484760927294548 no 1619 0.481708818349254 2322 3712 Induces cell cycle arrest. SGTC_1932 st074806 40.9 µM 0.0452358367911624 0.485027234234299 no 1620 0.481959664923327 2270 17251235 SGTC_2438 5259590 200 µM 0.0448712733269919 0.485181480828405 no 1621 0.482104957168658 2301 1201127 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0441340456310932 0.485493408198327 no 1622 0.48239877736259 2274 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3355 9151058 44.0485 µM 0.0423925794347626 0.4862302724084 no 1623 0.483092871893223 2338 17015728 SGTC_1681 tripelennamine 100 µM 0.0411394254820251 0.486760546961728 no 1624 0.483592372102296 2348 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2419 paclitaxel 166.5 µM 0.0401776655082666 0.487167533507718 no 1625 0.483975741796127 2279 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_158 k038-0087 26.446 µM 0.0393806981271977 0.487504795160302 no 1626 0.484293434317003 2246 X158 SGTC_2361 9034121 116 µM 0.0389172985828625 0.487700901282822 no 1627 0.484478162370873 2299 6496917 SGTC_1600 coumarin 106 71.1 µM 0.0381281455542188 0.488034869889929 no 1628 0.484792755356911 2299 100336 A hepatotoxic, DNA x-linker. SGTC_1725 st036284 20.55 µM 0.0380861534866475 0.488052641119309 no 1629 0.484809495608973 2333 707914 SGTC_2926 9010726 65.15 µM 0.0378453094157697 0.488154567856224 no 1630 0.484905509269767 2304 2994293 SGTC_1311 1190-0148 100 µM 0.0353465345617157 0.489212109635299 no 1631 0.485901708640119 2326 1961333 SGTC_990 3985-0011 41.3 µM 0.034634400899871 0.489513515987915 no 1632 0.486185634997738 2307 5399565 YGL099W LSG1 SGTC_1349 flufenamic acid 69 µM 0.0331524244264699 0.490140772748666 no 1633 0.486776518527315 2341 3371 A non-steroidal anti-inflammatory. SGTC_1492 4158-0558 28.5 µM 0.032969137768151 0.490218351816428 no 1634 0.486849599374494 2352 3967268 SGTC_1039 k821-0043 94 µM 0.0326737312497129 0.490343388221367 no 1635 0.486967386064435 2327 15992768 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0326693608271035 0.490345238092681 no 1636 0.486969128680489 2344 1273210 SGTC_1125 tnp00248 1.32998 µM 0.0317374349277503 0.490739699588063 no 1637 0.487340720579207 2343 24207736 SGTC_899 1083-0020 478 µM 0.0311692209637042 0.490980215164547 no 1638 0.487567293047596 2349 767123 SGTC_2925 9010536 32.5 µM 0.0304336473619253 0.491291576166663 no 1639 0.487860605281263 2316 2994177 SGTC_619 1652-1634 108 µM 0.0301917999143257 0.491393948958332 no 1640 0.487957044136141 2325 5400454 SGTC_269 exalamide 29 µM 0.0296074892179771 0.491641287023531 no 1641 0.4881900462006 2307 3316 A derivative of salicylamide. SGTC_191 3914-0123 66.505 µM 0.0290867920492808 0.49186170026454 no 1642 0.488397684879988 2348 3144412 SGTC_38 0929-0051 58.268 µM 0.0279299172191258 0.492351418907033 no 1643 0.488859023627994 2348 1379719 SGTC_3127 9126946 49.47 µM 0.0272386167123195 0.492644060044653 no 1644 0.4891347077203 2278 27243249 SGTC_1277 0873-0036 22 µM 0.027126999445743 0.492691310210139 no 1645 0.489179220118881 2350 5965735 SGTC_1893 st059353 36.1 µM 0.0268050846552949 0.492827584743973 no 1646 0.48930759885402 2245 3112488 SGTC_1512 0259-0544 12.2 µM 0.0267406784290753 0.49285484960172 no 1647 0.489333284013729 2288 18476 SGTC_36 0335-0881 14.2 µM 0.026250437847451 0.493062382481294 no 1648 0.489528793070199 2337 23828853 SGTC_2856 9022925 19.48 µM 0.0257390082593116 0.493278887274679 no 1649 0.489732755031329 2334 4944862 SGTC_1964 st076914 61 µM 0.0257258967008491 0.493284437850503 no 1650 0.489737984054853 2363 24208661 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.02526885999413 0.493477918088353 no 1651 0.48992025606064 2263 688788 SGTC_1235 benzylparaben 21.5 µM 0.0246305766361784 0.493748129174299 no 1652 0.490174815032344 2328 7180 SGTC_1807 st050092 58.9 µM 0.0245830491436144 0.493768249594861 no 1653 0.490193770019161 2342 5008496 SGTC_2148 5546263 113.568 µM 0.0244127694149262 0.493840336417415 no 1654 0.490261681420859 2351 792097 SGTC_1911 st060208 74.3 µM 0.0237538088106383 0.494119305004308 no 1655 0.490524492435396 2354 688783 SGTC_1449 4112-4002 201 µM 0.0231715114657399 0.494365820875764 no 1656 0.490756731530568 2308 2059539 SGTC_2692 st077426 47.7 µM 0.0227977437619765 0.494524056759323 no 1657 0.490905803887629 2358 25238571 SGTC_2511 berberine 10.47 µM 0.0226227767946479 0.494598129943328 no 1658 0.490975587610477 2366 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_803 4488-1585 147 µM 0.0224249403900535 0.494681885247865 no 1659 0.491054492898923 2359 747204 SGTC_2247 cerulenin 830 nM 0.0205625441939123 0.495470353547449 no 1660 0.49179730977365 2366 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_3296 9122258 64.045 µM 0.0205324374332701 0.49548309976791 no 1661 0.491809318098175 2349 4730474 SGTC_439 amiodarone 34.4 µM 0.0204554250795535 0.495515704307508 no 1662 0.491840035130905 2310 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2582 agaric acid 100 µM 0.0202227066273105 0.495614229954039 no 1663 0.491932857159542 2358 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1914 st062367 72.6 µM 0.0196289836735305 0.495865594708627 no 1664 0.492169671328239 2357 978205 SGTC_1285 0929-0069 65.5 µM 0.0185268524795566 0.496332208765243 no 1665 0.492609278029382 2362 1206237 SGTC_57 miconazole 162.5 nM 0.0177473913807262 0.496662215653266 no 1666 0.492920186868021 2376 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1819 st053448 58.6 µM 0.0170662587656168 0.496950594276215 no 1667 0.493191878297459 2352 2857616 SGTC_378 3970-0959 8.33 µM 0.0168340391147678 0.497048912041207 no 1668 0.493284507226863 2360 6615653 SGTC_1036 k216-0215 33.5 µM 0.0161802679469745 0.49732570833661 no 1669 0.49354528865068 2379 622330 SGTC_1924 st058459 75.1 µM 0.0150667293710631 0.497797165718751 no 1670 0.49398947203203 2383 688683 SGTC_423 5-fluorouracil 457 µM 0.0146853554679232 0.497958635083526 no 1671 0.494141601371926 2382 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0145733910990164 0.498006039586154 no 1672 0.494186263912996 2366 688761 SGTC_187 1488-2104 32.728 µM 0.0140115468677146 0.498243918767551 no 1673 0.494410384436672 2364 2852859 SGTC_1831 st055328 12 µM 0.0134023954960022 0.498501828017874 no 1674 0.494653377842255 2384 1103068 SGTC_2259 7964009 200 µM 0.013015221799105 0.498665754235482 no 1675 0.494807824324912 2346 313134 SGTC_75 0159-0059 199.013 µM 0.0120028612598776 0.499094380509206 no 1676 0.495211666132741 2376 5377270 SGTC_493 zm226600 134 µM 0.010075354500967 0.499910475681006 no 1677 0.495980583103336 2382 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2018 5133068 143 µM 0.00993372812611815 0.499970439522291 no 1678 0.496037081024703 2387 785362 SGTC_3237 9133362 49.47 µM 0.00979409253372582 0.499970439522291 no 1679 0.496092784856345 2385 43845137 SGTC_2651 TUB2.036 5 µM 0.00915440216018102 0.499699598102262 no 1680 0.496347972935096 2375 15992207 YFL037W TUB2 SGTC_925 2064-1272 59.6 µM 0.00771213275259071 0.499088949790077 no 1681 0.496923334671419 2384 6815817 SGTC_2677 mitomycin C 100 µM 0.00693935256813011 0.498761760030984 no 1682 0.497231621080348 2392 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2028 5153890 36.43 µM 0.00655345568142656 0.498598374269282 no 1683 0.497385568159963 2389 2830968 YPR165W RHO1 SGTC_1983 st071813 46.9 µM 0.00626933611297623 0.498478080386867 no 1684 0.497498913138523 2375 11838595 SGTC_1712 st032288 53.4 µM 0.00498229039434822 0.497933157737036 no 1685 0.498012361931722 2396 2883011 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.00422384295980962 0.497612040204414 no 1686 0.498314935468055 2394 6708760 SGTC_1751 st044839 27.194 µM 0.00414851836137305 0.497580148755353 no 1687 0.498344985371818 2400 5291326 SGTC_1729 st035615 45.989 µM 0.00363201048008434 0.497361466506241 no 1688 0.498551040642292 2351 17385451 SGTC_2294 7971431 200 µM 0.00270843066730915 0.496970437685594 no 1689 0.498919493814301 2397 5741572 SGTC_3085 9117376 49.47 µM 0.00257189871020691 0.496912632491373 no 1690 0.498973961994738 2394 16480349 SGTC_2987 9018338 71.43 µM 0.00254157615740988 0.49689979447238 no 1691 0.49898605890356 2395 5055682 SGTC_2954 9074818 52.69 µM 0.0024627346382609 0.496866414417922 no 1692 0.49901751202053 2395 16648742 SGTC_932 2857-0803 154 µM 0.00245612173102492 0.496863614635172 no 1693 0.499020150180844 2399 674898 SGTC_3210 9128157 49.47 µM 0.00219789871241641 0.496754287901934 no 1694 0.49912316598154 2390 17590849 SGTC_2653 dihydrofissinolide 100 µM 0.00177896363301398 0.496576919249506 no 1695 0.499290296565829 2404 6857746 SGTC_500 h-89 112 µM 0.00163338481567937 0.496515284274778 no 1696 0.49934837402661 2402 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2086 5274770 176.623 µM 0.00161565207852683 0.496507776616705 no 1697 0.499355448355873 2402 689278 SGTC_1884 5633444 25 µM 0.000916335800310077 0.496211702215602 no 1698 0.49963443495737 2401 5724239 SGTC_2967 9089538 49.85 µM 0.000142614593003379 0.495884128919904 no 1699 0.499943105009242 2403 728216 SGTC_1230 0170-0365 3.77 µM 0 0.4958237499326 no 1700 0.5 2405 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_3230 9131665 49.47 µM 0 0.4958237499326 no 1701 0.5 2406 15943720 SGTC_306 1672-3436 11.6 µM -0.000262423886919009 0.495712647327971 no 1702 0.499895308017322 2406 6797378 SGTC_1797 st048695 56.8 µM -0.000778619516245138 0.495494106162356 no 1703 0.49968937578601 2407 592262 YIL048W NEO1 SGTC_877 0771-0151 33.1 µM -0.00095115353731733 0.49542106092532 no 1704 0.499620544696026 2412 6166523 SGTC_3323 9138564 53.9225 µM -0.00132487177805902 0.49526284142795 no 1705 0.499471452786247 2409 43912313 YNL103W MET4 SGTC_1074 carmofur 3.8 µM -0.0013759659926595 0.495241209945621 no 1706 0.499451069162347 2406 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1881 5652484 16 µM -0.00158217618802085 0.495153907989158 no 1707 0.499368803286898 2409 2255129 SGTC_2180 6301957 200 µM -0.00216698107294348 0.494906323977524 no 1708 0.499135500305761 2412 845462 SGTC_2657 nystatin 74.44 µM -0.00304987913196483 0.494532542469775 no 1709 0.498783276150425 2418 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1038 k292-0204 154 µM -0.00346803806372857 0.494355513408258 no 1710 0.498616455759719 2394 4454212 SGTC_2624 nerol 100 µM -0.003521450331275 0.494332901215367 no 1711 0.498595147478027 2412 637566 A natural product oil. SGTC_2968 9090663 33.37 µM -0.00383222719161904 0.494201333558371 no 1712 0.498471166287226 2432 25236811 SGTC_2827 7993847 71.43 µM -0.00391993426604738 0.494164202804825 no 1713 0.498436176489802 2419 2985692 SGTC_669 0108-0021 26.2 µM -0.0044755076345444 0.493929002237706 no 1714 0.498214536738845 2417 17201 SGTC_1720 st037298 9.481 µM -0.00470803519757597 0.493830562909363 no 1715 0.498121772640743 2420 597396 SGTC_791 1348-1292 225 µM -0.00475167135163253 0.493812089813323 no 1716 0.498104364528661 2432 5437054 SGTC_1116 jasmonic acid  1.58368 µM -0.00483884882016986 0.493775183810769 no 1717 0.498069586150432 2418 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1178 0988-0033 191 µM -0.00523182797647721 0.493608819359859 no 1718 0.49791281213816 2422 5392207 SGTC_1194 1488-0194 225 µM -0.0065108476453143 0.493067364888954 no 1719 0.497402565944409 2419 1391452 SGTC_3113 9123498 49.47 µM -0.00716759459967499 0.492789345468346 no 1720 0.49714056794904 2412 8897275 SGTC_2015 5119600 184 µM -0.00882756556170717 0.492086649086352 no 1721 0.496478356602359 2429 2828786 SGTC_965 1291-5240 308 µM -0.00884580742383812 0.492078927101452 no 1722 0.496471079436413 2427 2834598 SGTC_841 0251-0215 91.2 µM -0.00991094618198744 0.491628047158025 no 1723 0.496046169258054 2449 3888614 SGTC_2102 5377816 72.7585 µM -0.010014376154675 0.491584265159838 no 1724 0.496004908716607 2426 1379702 SGTC_1203 3992-3522 103 µM -0.0103789240980744 0.491429952507527 no 1725 0.495859482689847 2423 5322312 SGTC_121 0557-0495 61.343 µM -0.0106589551268954 0.491311416620892 no 1726 0.495747772653413 2430 3104427 SGTC_3165 9101544 49.47 µM -0.0111338939804334 0.491110378880384 no 1727 0.49555831071385 2426 5002184 SGTC_840 0245-0196 390 µM -0.0116547251490824 0.490889917895346 no 1728 0.495350542629806 2463 3827528 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0130166542101346 0.490313444557084 no 1729 0.494807252923994 2419 6708561 SGTC_3058 9093861 49.47 µM -0.0130639945142574 0.490293406848918 no 1730 0.494788368480832 2430 17217477 SGTC_926 2268-1401 59.4 µM -0.0133279654179011 0.490181676459755 no 1731 0.494683068495426 2425 2931578 SGTC_2789 5281112 71.43 µM -0.0134346587866926 0.490136516808179 no 1732 0.494640507810215 2441 765948 SGTC_1520 flindersine 88 µM -0.0138160954439213 0.489975068763426 no 1733 0.494488350725979 2446 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_939 1165-0479 45.3 µM -0.0138697743194913 0.489952348609803 no 1734 0.494466938004677 2433 1377347 SGTC_1717 st033143 58.0435 µM -0.0142736044097239 0.489781424289805 no 1735 0.494305849058277 2433 674616 SGTC_922 1866-0035 480 µM -0.0144658048173326 0.489700074585122 no 1736 0.494229180105523 2439 3156169 SGTC_1269 0831-0796 3.05 µM -0.0154826312643556 0.489269705334407 no 1737 0.493823570538346 2444 927758 SGTC_2462 5162487 171.77 µM -0.0155185845710841 0.489254488412979 no 1738 0.493809228967193 2426 2259986 SGTC_2621 lithochol-11-enic acid 100 µM -0.015752288394929 0.489155575703565 no 1739 0.493716006026638 2431 6708711 SGTC_683 panaxydol 45 µM -0.0170420472214239 0.488609710875054 no 1740 0.49320153590158 2459 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2305 7443522 69.23 µM -0.0170838924311744 0.488592001072247 no 1741 0.493184844508164 2448 5415886 SGTC_2725 haloperidol 53.21 µM -0.0181428102177539 0.488143851616617 no 1742 0.492762462974183 2429 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_673 1082-0474 110 µM -0.018286857372855 0.4880828899032 no 1743 0.492705006006023 2441 3098046 SGTC_1146 3579-1023 7 µM -0.0184105829215274 0.488030528650917 no 1744 0.492655654961867 2478 X1146 SGTC_257 daunorubicin 18.5 µM -0.0198478147267254 0.487422300532386 no 1745 0.492082387373792 2510 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3189 9110682 49.47 µM -0.0199166004437585 0.487393191540365 no 1746 0.492054951266297 2456 17122418 SGTC_271 rotenone 740 µM -0.0207342567319665 0.487047177940705 no 1747 0.491728820984104 2504 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2241 6772625 37.8075 µM -0.0211480699467128 0.486872065271731 no 1748 0.491563769591884 2430 2285411 SGTC_867 0518-0118 155 µM -0.021833537757954 0.486582002551631 no 1749 0.491290370648054 2455 6848158 SGTC_886 0866-0150 153 µM -0.02226908289638 0.486397700846959 no 1750 0.491116655519204 2448 271463 SGTC_136 0097-0015 404.482 µM -0.023121851025587 0.486036858936272 no 1751 0.490776537873284 2435 4861337 SGTC_1546 5-methoxyflavanone 78.7 µM -0.0246129609798582 0.485405935513701 no 1752 0.490181840532584 2455 147795 SGTC_52 0329-0193 875 nM -0.0251139266168991 0.485193973380824 no 1753 0.489982045926172 2529 3739292 SGTC_3201 9113999 49.47 µM -0.0255484074249156 0.485010144838415 no 1754 0.489808768765319 2499 16649224 SGTC_1649 st011737 51.3 µM -0.0257116934456533 0.484941059452571 no 1755 0.489743648460181 2473 1761035 SGTC_753 1322-0200 289 µM -0.0261123428397513 0.484771548894176 no 1756 0.489583866128871 2495 5403907 SGTC_1394 3474-0001 65.7 µM -0.0264828206978939 0.484614806044567 no 1757 0.489436117945558 2488 5017666 YIL048W NEO1 SGTC_1966 st070145 16.1 µM -0.0269748149489622 0.484406655364941 no 1758 0.489239910739719 2448 3748532 SGTC_523 1934-0222 13.7 µM -0.0278606406406059 0.484031895029831 no 1759 0.488886650233336 2466 1361595 SGTC_643 k048-0106 28.4 µM -0.028231660897867 0.483874934149809 no 1760 0.488738692768799 2510 6763920 SGTC_1773 st048542 73.5835 µM -0.0282715635111891 0.483858053415878 no 1761 0.48872278028082 2454 3237138 SGTC_2703 st077852 53.4 µM -0.0290574713361984 0.483525582358035 no 1762 0.48840937720997 2481 6281836 SGTC_1885 st057546 99.9 µM -0.0302249543654279 0.483031710644591 no 1763 0.487943823457429 2555 702008 SGTC_1468 k284-1086 134 µM -0.0313228623188384 0.482567294500695 no 1764 0.487506028928919 2466 15996457 SGTC_113 0099-0221 2.5 µM -0.0316191036751755 0.482441988141553 no 1765 0.487387904238282 2455 89219 SGTC_2857 9024691 58.44 µM -0.0317475921948471 0.482387639656084 no 1766 0.487336670456849 2513 16478292 SGTC_982 1491-0518 27.5 µM -0.0333118511860686 0.481726010927326 no 1767 0.486712951562927 2490 3091256 SGTC_872 0588-0139 234 µM -0.0338187740458606 0.481511610385964 no 1768 0.486510832492217 2474 2047100 SGTC_2497 7-hydroxyflavone 100 µM -0.0343885829602231 0.481270618882397 no 1769 0.486283643783173 2481 5281894 SGTC_626 0214-0009 33 µM -0.0344034534847876 0.48126432972478 no 1770 0.486277714810473 2495 3437874 SGTC_2308 7584454 197.62 µM -0.0354406819709902 0.480825668600722 no 1771 0.485864172776077 2475 893577 SGTC_1172 0370-0043 85 µM -0.0356084792972725 0.480754706497196 no 1772 0.485797273554753 2510 376585 SGTC_3353 9151644 39.2805 µM -0.0375483591935103 0.47993436904166 no 1773 0.485023891124931 2527 4909158 SGTC_2834 9001755 58.44 µM -0.038464933958054 0.479546796760506 no 1774 0.484658494714819 2588 2989575 SGTC_2020 4017018 200 µM -0.0391549472426163 0.479255038403604 no 1775 0.484383426480513 2511 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1065 prochlorperazine maleate 2.48 µM -0.0393336491520697 0.479179479670681 no 1776 0.484312189610949 2470 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1080 nisoldipine 24.4 µM -0.0395577376583022 0.479084731636767 no 1777 0.484222860754673 2481 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_416 estradiol valerate 100 µM -0.0396348344277338 0.479052134221246 no 1778 0.484192127695775 2503 13791 A steroid. SGTC_3257 9139206 32.98 µM -0.0399652601764954 0.478912427941186 no 1779 0.484060411258284 2483 4910041 SGTC_1409 3909-8004 61.9 µM -0.0400885937444659 0.478860282323139 no 1780 0.484011247683069 2501 2119279 SGTC_2881 9058953 51.95 µM -0.0402565858188306 0.478789255603694 no 1781 0.483944282599082 2478 17122249 SGTC_1379 2144-0755 36.5 µM -0.0404024537741316 0.478727583464666 no 1782 0.483886137009674 2482 5392327 SGTC_1779 st039427 55 µM -0.0408612307558899 0.478533618501975 no 1783 0.48370326249633 2467 1124498 SGTC_528 3492-0019 172 µM -0.0410820388562271 0.478440265508069 no 1784 0.48361524671538 2476 2869262 SGTC_1607 st000305 50.6 µM -0.0413694335152386 0.478318762898123 no 1785 0.483500690224397 2468 5457690 SGTC_333 3486-0131 40.1 µM -0.0418695906985658 0.47810731491727 no 1786 0.483301329119029 2566 6744690 SGTC_758 0868-0029 16 µM -0.0440436348157317 0.477188281754257 no 1787 0.482434811020829 2475 762687 SGTC_1900 st060200 72.8 µM -0.0442579969915969 0.477097670972482 no 1788 0.482349376195132 2479 688945 SGTC_1111 tnp00062 510.699 nM -0.0444197045183878 0.47702931806711 no 1789 0.482284927607677 2560 676306 SGTC_3252 9135871 49.47 µM -0.0470141389151539 0.475932758321835 no 1790 0.481250979382512 2570 17682838 SGTC_3326 9140064 16.379 µM -0.0472754189393178 0.475822336062543 no 1791 0.481146859508451 2497 1868434 SGTC_647 0140-0236 81 µM -0.0474900593610329 0.475731626037916 no 1792 0.481061326439394 2530 990837 SGTC_2794 7785382 27.27 µM -0.0476037667277366 0.475683572234139 no 1793 0.481016015010181 2474 2205081 SGTC_897 1000-0139 31.4 µM -0.0477279964420473 0.475631071991502 no 1794 0.480966510794335 2480 6151020 SGTC_1961 st076550 68.7 µM -0.0481492742580481 0.47545304054636 no 1795 0.48079863826884 2543 1579337 SGTC_725 1497-0963 19 µM -0.0487954694802129 0.475179968840354 no 1796 0.480541146353301 2498 3549977 SGTC_24 0417-1663 219 µM -0.0494972292404262 0.474883429663765 no 1797 0.480261522620497 2520 4329390 SGTC_525 k781-2675 26.7 µM -0.0499179633425499 0.474705648780749 no 1798 0.480093881235523 2496 3651118 YDL195W SEC31 SGTC_1698 5-fluorocytosine 1.055 µM -0.0499451902384546 0.474694144249193 no 1799 0.480083032807462 2503 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_363 0455-0021 3.06 µM -0.0525831653573703 0.473579588106275 no 1800 0.479032015255408 2516 4597466 SGTC_712 r015-0009 80.6 µM -0.0531144985071334 0.473355122242125 no 1801 0.478820339810633 2532 6813872 YLR060W FRS1 SGTC_3232 9132874 49.47 µM -0.0546203450197467 0.472719011750407 no 1802 0.478220464985344 2510 3784940 SGTC_1752 st044819 83.042 µM -0.0552852209138411 0.472438172146905 no 1803 0.477955618080341 2535 441209 YML126C ERG13 SGTC_3060 1327-0027 12.5 µM -0.0553989082526025 0.472390152662416 no 1804 0.477910332795933 2532 16000455 YPR107C YTH1 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0558889548096857 0.472183170423736 no 1805 0.477715134931345 2572 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1839 st053978 48 µM -0.0565866726255461 0.471888486510453 no 1806 0.477437225618835 2491 3788398 SGTC_1880 MG-132 525 µM -0.0569652820765378 0.471728585723374 no 1807 0.477286425550834 2540 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1874 staurosporine 7.6 µM -0.0577709518397752 0.471388336755016 no 1808 0.47696553829775 2557 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1659 st012954 42.1 µM -0.058329927883333 0.471152283278659 no 1809 0.476742914544052 2578 24207262 SGTC_3089 9117425 49.47 µM -0.0586980960523352 0.470996812779301 no 1810 0.476596287927625 2564 9401657 SGTC_2433 5607874 27.82 µM -0.058987876695177 0.470874446966763 no 1811 0.476480882146693 2511 2252428 SGTC_2333 9017922 200 µM -0.0590277837149542 0.47085759562534 no 1812 0.476464989242262 2568 3163164 SGTC_906 1165-0455 526 µM -0.0602737653786492 0.470331487463048 no 1813 0.475968798071203 2496 3252859 SGTC_2272 7805186 180 µM -0.0609698135175664 0.470037607864637 no 1814 0.475691624819229 2513 2956062 YPR165W RHO1 SGTC_128 0906-2981 13.371 µM -0.0619097882982601 0.469640765538346 no 1815 0.475317336258973 2543 6740226 SGTC_1198 1612-1005 86.7 µM -0.062281162126399 0.469483985733317 no 1816 0.475169464897679 2612 6998509 SGTC_686 1319-0111 510 µM -0.0637670309488505 0.468856756407409 no 1817 0.47457786515104 2539 4562600 SGTC_2876 9059903 25.97 µM -0.0643006702580977 0.46863151020052 no 1818 0.474365409886188 2524 6916095 SGTC_3217 9129673 49.47 µM -0.0643705685554592 0.4686020072572 no 1819 0.474337582150182 2587 17248312 SGTC_3009 9080819 71.4286 µM -0.065197284023161 0.468253077123648 no 1820 0.474008461782806 2577 17027216 SGTC_199 4063-0024 41.6 µM -0.0670819264195287 0.467457721493379 no 1821 0.473258241054609 2616 306215 SGTC_1573 oleylamine 1.06 µM -0.0676694838694338 0.467209787271572 no 1822 0.473024370976838 2524 5356789 An amine of the fatty acid oleic acid. SGTC_1085 doxorubicin 7.67 µM -0.0686418535570583 0.466799500117153 no 1823 0.47263735154656 2529 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1454 4239-0054 42.6 µM -0.0688182364403086 0.466725079894884 no 1824 0.472567150960382 2687 1340767 SGTC_873 0591-4978 488 µM -0.0715642212233063 0.46556663387546 no 1825 0.471474357182947 2562 3305145 SGTC_1540 guanosine 70.6 µM -0.0724034673580916 0.46521263964935 no 1826 0.471140412743235 2515 6802 Guanosine is a purine nucleoside SGTC_2052 5265182 7.135 µM -0.0732970248771193 0.464835767131896 no 1827 0.470784879568998 2583 1239884 SGTC_539 4859-0462 2.54 µM -0.0735319676937063 0.46473668137456 no 1828 0.470691403190196 2577 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2905 7799065 20.05 µM -0.0740780080634337 0.464506400502913 no 1829 0.470474157097963 2576 1296806 SGTC_2762 leflunomide 42.06 µM -0.074093088971078 0.464500040620341 no 1830 0.470468157174687 2550 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2915 7971052 15.16 µM -0.0758469684634266 0.463760461244298 no 1831 0.469770424143466 2531 5741558 SGTC_3118 9124250 49.47 µM -0.0761727227460119 0.463623110245671 no 1832 0.469640841859491 2610 1504786 SGTC_775 4577-0580 57.3 µM -0.0763898031477988 0.463531582896161 no 1833 0.46955449090577 2735 2006902 SGTC_2728 chlorpromazine 9.18 µM -0.0770034046302707 0.463272881293869 no 1834 0.469310418254337 2529 2726 A thorazine and dopamine antagonist. SGTC_2741 miltefosine 3.04 µM -0.0774111887932424 0.463100963278075 no 1835 0.469148220061721 2564 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1715 st032160 10.2275 µM -0.0777582380320808 0.462954655969162 no 1836 0.469010183521202 2585 5289825 SGTC_3308 9128332 17.569 µM -0.0800323401005642 0.461996076120611 no 1837 0.468105767389064 2611 17332805 YDL196W YDL196W SGTC_635 k038-0028 24.7 µM -0.080257477409352 0.461901188123905 no 1838 0.468016238591068 2578 4035102 SGTC_2705 st078069 42.8 µM -0.0818213658898379 0.461242120527919 no 1839 0.467394382758054 2613 1530061 SGTC_989 1501-0895 10.3 µM -0.0824787594101329 0.460965107655699 no 1840 0.467133004156443 2534 2830112 SGTC_756 0508-1999 28.3 µM -0.0825588793666989 0.460931347952951 no 1841 0.467101149557754 2558 6753853 SGTC_1692 fluoroquinolonic acid 71 µM -0.0836251290470387 0.460482095127431 no 1842 0.466677243411236 2663 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1665 st014639 11.4 µM -0.0838364929944386 0.460393045175442 no 1843 0.466593216463197 2582 981133 YIL048W NEO1 SGTC_1161 k007-0610 110 µM -0.0841366250314824 0.460266599666593 no 1844 0.466473902651725 2576 5843850 SGTC_118 0083-0097 135.343 µM -0.0847737851554543 0.4599981776926 no 1845 0.466220617457145 2584 5207356 SGTC_159 3970-0959 50 µM -0.0856484106633696 0.4596297463278 no 1846 0.46587295683739 2633 6615653 SGTC_996 3970-0799 1.8 µM -0.0873454277354335 0.458914986031831 no 1847 0.465198472931535 2575 6615648 YGL040C HEM2 SGTC_499 genistein 192 µM -0.0875733981649589 0.458818978083678 no 1848 0.465107873058138 2546 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1002 4049-0206 172 µM -0.0885874039711121 0.458391966717693 no 1849 0.464704909449838 2593 4662749 SGTC_2823 7987624 58.44 µM -0.0893438318871031 0.458073456075721 no 1850 0.464404330260339 2652 2239440 SGTC_2959 9079155 11 µM -0.0900843121042109 0.457761686637893 no 1851 0.4641101078278 2689 16189457 SGTC_2775 cyproheptadine 69.59 µM -0.0906465816777322 0.457524967791935 no 1852 0.463886708718455 2553 2913 A selective serotonin reuptake inhibitor. SGTC_289 k017-0060 526 µM -0.0912530194211481 0.45726967077487 no 1853 0.463645773620854 2580 5512909 SGTC_2424 5537928 59.2 µM -0.0918775292115169 0.457006784251062 no 1854 0.463397672512632 2590 5382802 SGTC_2786 7743617 45.45 µM -0.0922134264178619 0.456865396564641 no 1855 0.463264235379134 2612 583674 SGTC_1619 st003326 88.7 µM -0.0923343101376614 0.456814514864343 no 1856 0.463216214623669 2618 2849032 SGTC_376 3970-0862 59.1 µM -0.0924668971186539 0.456758707906877 no 1857 0.463163545393321 2637 3135186 SGTC_125 0133-0007 11.75 µM -0.0926237466116146 0.456692689758638 no 1858 0.463101238887387 2658 26541 SGTC_3137 9097352 49.47 µM -0.0934484314974586 0.456345598562886 no 1859 0.462773658023055 2721 44120435 SGTC_3134 9127454 49.47 µM -0.0937711939744422 0.456209764198537 no 1860 0.462645457355539 2546 24262820 SGTC_213 1246-0773 967 nM -0.0942783467555727 0.455996339646808 no 1861 0.462444025038555 2611 6251622 SGTC_1775 st081588 35.1725 µM -0.0956481983999837 0.455419930106301 no 1862 0.461899991932375 2577 1426443 YGL099W LSG1 SGTC_228 caffeine 993.056 µM -0.0958488595441882 0.455335503267279 no 1863 0.461820305828881 2641 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2543 pimpinellin 60.67 µM -0.0965955809525193 0.455021342961742 no 1864 0.461523782986908 2577 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_548 1436-0017 110 µM -0.0971432880457679 0.454790929743477 no 1865 0.461306302255925 2604 9677137 SGTC_364 0083-0097 67.7 µM -0.0972951874479571 0.454727030340347 no 1866 0.461245988865061 2697 5207356 SGTC_543 3844-1095 191 µM -0.0975869686150924 0.454604290272095 no 1867 0.461130136325109 2678 4230703 SGTC_2225 6654152 15.4 µM -0.10015862906442 0.453522689606953 no 1868 0.460109195011436 2581 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2486 5283202 22.39 µM -0.10210728940996 0.452703342251052 no 1869 0.459335757572963 2650 1377751 SGTC_323 4013-0906 34.3 µM -0.10260190945511 0.452495402749622 no 1870 0.459139463657053 2697 2910086 SGTC_1982 st072467 71.9 µM -0.10355475812575 0.452094859563221 no 1871 0.458761346171242 2557 3163533 SGTC_1189 1431-2119 7.28 µM -0.103633386697155 0.452061809122054 no 1872 0.458730145776776 2564 3107275 SGTC_2094 5332512 191.667 µM -0.103993437852675 0.451910470805948 no 1873 0.458587278085063 2684 755774 SGTC_469 w7 172 µM -0.104512450585025 0.451692329349052 no 1874 0.458381344125482 2574 45115570 A P450 inhibitor. SGTC_2769 toremifene 3.73 µM -0.105944769697306 0.451090400370242 no 1875 0.457813086422347 2718 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2002 4023503 131 µM -0.106265215834235 0.450955748925591 no 1876 0.457685964514475 2593 4736863 YCR052W RSC6 SGTC_660 4031-1742 102 µM -0.106968868218225 0.45066009406667 no 1877 0.457406838788502 2590 6738706 SGTC_2882 9058044 58.44 µM -0.107221131896848 0.450554106651314 no 1878 0.45730677561927 2677 18076804 SGTC_2090 5301565 104.445 µM -0.107571819441965 0.450406772764084 no 1879 0.457167676036086 2623 2056344 SGTC_2982 9019404 25.97 µM -0.108473729856533 0.450027885791312 no 1880 0.456809959036498 2627 22333232 SGTC_476 mead acid 10 µM -0.109685006343813 0.449519107769111 no 1881 0.456329595933355 2601 5312531 An omega 9 fatty acid. SGTC_855 0428-0020 25 µM -0.109931372626193 0.449415635536649 no 1882 0.456231900782348 2618 6812414 SGTC_1563 conessine 56.1 µM -0.112646360683365 0.448275587602139 no 1883 0.455155464214029 2692 441082 An anti-amoebic, histamine inhibitor. SGTC_60 0986-0278 202 µM -0.112754081254753 0.448230363510204 no 1884 0.455112761974419 2605 3110598 SGTC_2059 5238311 157 µM -0.113482599263547 0.447924529078638 no 1885 0.454823978867512 2620 703021 SGTC_56 0957-0365 83.25 µM -0.113682540831884 0.447840598308153 no 1886 0.454744726591592 2587 6752360 SGTC_3063 1327-0034 4 µM -0.114026149243514 0.447696365030911 no 1887 0.454608532266523 2602 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_698 k064-0052 127 µM -0.114057829797141 0.447683067130235 no 1888 0.454595975474434 2575 5088751 SGTC_762 1165-0429 115 µM -0.114107081615684 0.447662393814378 no 1889 0.454576454288089 2634 5967793 SGTC_462 ag-879 158 µM -0.114149242405335 0.447644697051407 no 1890 0.454559743751032 2668 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_746 1095-0025 46.6 µM -0.114597846750288 0.447456404269695 no 1891 0.454381943255109 2708 6749286 SGTC_3002 9075603 71.4286 µM -0.114901454870064 0.447328977495597 no 1892 0.454261615957267 2602 20105405 SGTC_392 N-ethylmaleimide 8.33 µM -0.114925972801882 0.447318687359138 no 1893 0.454251899086328 2642 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1098 clofazimine 15.1 µM -0.115600731501876 0.447035506161551 no 1894 0.453984491569955 2704 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1992 st073643 23.3 µM -0.115617647030398 0.447028407437323 no 1895 0.453977788197361 2615 3161292 SGTC_3155 9099265 49.47 µM -0.11755562451697 0.446215234046033 no 1896 0.45320988378206 2716 25236499 SGTC_2014 4013930 200 µM -0.118226738271594 0.445933687937746 no 1897 0.452944002224959 2607 64556 SGTC_1615 st002656 86.5 µM -0.120105165244503 0.445145794322802 no 1898 0.452199920370008 2596 1584458 SGTC_2255 7941087 197.44 µM -0.120407207348746 0.445019124921367 no 1899 0.452080291151504 2667 935561 SGTC_1169 aniline yellow 25.8 µM -0.12269888072827 0.444058234439631 no 1900 0.451172775109559 2667 6051 A DNA damaging agent. SGTC_3294 9122953 26.2835 µM -0.123251078303943 0.443826748902009 no 1901 0.450954139613704 2629 16459826 SGTC_1016 4226-1401 38 µM -0.124385678226441 0.443351175979607 no 1902 0.45050495620132 2598 2901613 SGTC_2858 9025781 8.96 µM -0.125231428481974 0.442996728796757 no 1903 0.45017016838074 2712 4894980 YPL153C RAD53 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.125509572711044 0.442880170723174 no 1904 0.450060073519268 2705 5379071 SGTC_3327 9140648 26.9345 µM -0.129123316195243 0.44136626191407 no 1905 0.448630036396005 2697 8029710 SGTC_2587 piperic acid 92.2 µM -0.129804026759837 0.441081186396174 no 1906 0.448360738489157 2698 5370536 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.130885977138016 0.440628138097553 no 1907 0.447932753935119 2696 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2111 5486399 200 µM -0.132444541858824 0.43997565239357 no 1908 0.447316342827747 2629 689674 SGTC_2884 9058502 51.95 µM -0.133265070875296 0.43963220720369 no 1909 0.446991875283396 2736 6471554 SGTC_1415 3966-0071 78.1 µM -0.135840143279815 0.438554666740812 no 1910 0.445973827713871 2657 2893185 SGTC_2186 6124449 200 µM -0.135956055690036 0.438506173778179 no 1911 0.445928010395908 2769 3834182 YLR033W RSC58 SGTC_235 0330-0087 5 mM -0.136095543725607 0.438447818972112 no 1912 0.445872875171797 2655 46494818 YHR062C RPP1 SGTC_2235 salicylic acid 500 µM -0.136705387319921 0.438192706694903 no 1913 0.44563183552497 2649 338 A COX inhibitor and kinase inhibitor. SGTC_1344 1488-0097 29.1 µM -0.137220807758057 0.437977113921851 no 1914 0.445428132135376 2742 747966 SGTC_225 nsc-122657 1.016 µM -0.137321866700446 0.437934844612186 no 1915 0.445388193518753 2756 275685 SGTC_968 1309-0633 340 µM -0.137495592554945 0.437862183010126 no 1916 0.445319538145875 2685 3761976 SGTC_2282 7944268 200 µM -0.137870659359168 0.437705316818719 no 1917 0.445171319681777 2767 2970414 SGTC_1123 mangostin 811.285 nM -0.138007364179075 0.437648144465354 no 1918 0.445117298734565 2743 5281650 An antioxidant. SGTC_124 0136-0217 7.121 µM -0.139411806111962 0.437060857808747 no 1919 0.444562371767755 2684 3976905 SGTC_1338 1486-1223 76 µM -0.142049843286272 0.435958102235493 no 1920 0.443520317787862 2728 3444526 SGTC_1822 st052468 42 µM -0.142348145087501 0.435833436908178 no 1921 0.443402509701228 2692 2873678 SGTC_829 1635-0120 117 µM -0.142425434942355 0.435801137220596 no 1922 0.443371986497549 2802 285054 SGTC_3289 9119912 71.43 µM -0.142597605001092 0.435729188319703 no 1923 0.443303994541766 2768 17014829 SGTC_874 0599-0792 117 µM -0.142661987093765 0.435702283950978 no 1924 0.443278569734342 2646 765305 SGTC_1816 st051957 91.6 µM -0.143895429559177 0.435186903340593 no 1925 0.442791522405864 2660 674121 SGTC_1647 st011722 22.4 µM -0.144991540617781 0.434728997527036 no 1926 0.442358775410545 2790 2854783 SGTC_179 1273-0063 6.77 µM -0.14552458931131 0.434506345398496 no 1927 0.442148351465856 2681 3108139 SGTC_1059 3448-6867 171 µM -0.14694396787076 0.433913578605789 no 1928 0.441588123617443 2642 3934407 SGTC_2536 dehydroabietamide 32.04 µM -0.146981201672181 0.433898030864622 no 1929 0.441573429026616 2789 3983547 SGTC_368 fentichlor 4.58 µM -0.147161880543139 0.433822586130927 no 1930 0.441502123936979 2746 7329 A pesticide. SGTC_584 0986-0246 15.4 µM -0.148330793648008 0.433334550141584 no 1931 0.441040857169534 2657 53315 YDR232W HEM1 SGTC_99 0109-0120 622.8 µM -0.149389667764455 0.432892544535766 no 1932 0.440623082087982 2688 759414 SGTC_2586 curcumin 80 µM -0.152264294476455 0.431693014542255 no 1933 0.439489242693635 2783 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_524 r073-0010 27.8 µM -0.153540808413831 0.4311605494457 no 1934 0.438985905676252 2658 2772106 SGTC_845 0330-0138 4.51 µM -0.153713179807283 0.431088658698123 no 1935 0.438917946155006 2734 9039800 SGTC_2167 5876490 200 µM -0.154191921118948 0.430889002569056 no 1936 0.438729206013572 2923 686534 SGTC_2406 ethylparaben 405.7 µM -0.154230263053282 0.430873013063625 no 1937 0.438714090597957 2667 8434 A possible steroid mimic. SGTC_923 1900-2434 73.3 µM -0.154762733736204 0.430650971753672 no 1938 0.438504185668408 2658 5910570 SGTC_1402 3909-7673 35.9 µM -0.154776877802743 0.430645073949014 no 1939 0.4384986101805 2648 5328014 SGTC_1206 3978-0017 132 µM -0.15535279696715 0.430404939848919 no 1940 0.43827159742383 2962 3873677 SGTC_638 3970-0837 4.09 µM -0.157912094185576 0.429338132899253 no 1941 0.437263033929284 2723 4118451 YLR208W SEC13 SGTC_973 1325-0077 65.9 µM -0.159189304706848 0.428805938174066 no 1942 0.436759865010197 2769 2835149 SGTC_245 methotrexate 289.6 µM -0.159836704168615 0.428536225762176 no 1943 0.436504855010064 2753 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_986 1493-0483 84 µM -0.159957034769993 0.428486098630635 no 1944 0.436457459811476 2680 40079 SGTC_962 1254-0300 21.5 µM -0.161125236199773 0.427999511216938 no 1945 0.435997382157223 2678 7340576 SGTC_1790 st045711 43.5 µM -0.161706618333049 0.427757390621867 no 1946 0.435768446232563 2776 585119 SGTC_449 xestospongin c 11.1929 µM -0.161936155575783 0.427661805740308 no 1947 0.435678065267834 2806 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1750 st081859 2.357 µM -0.164264922090459 0.426692291792217 no 1948 0.434761297335529 2713 5291695 SGTC_2875 9039966 71.43 µM -0.16444206245825 0.426618562618278 no 1949 0.43469157659187 2800 6463691 SGTC_2638 epoxomicin 18 µM -0.164505089943547 0.42659233000426 no 1950 0.434666770070084 2804 9915668 A protesome inhibitor. SGTC_1106 tegaserod maleate 11.7 µM -0.164649604112976 0.426532183115399 no 1951 0.434609892778079 2745 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1863 st057641 20.1 µM -0.165464191050349 0.426193183512689 no 1952 0.434289316351105 2690 3921635 SGTC_587 k089-0003 57 µM -0.166478006281177 0.425771348985421 no 1953 0.433890395044141 2671 9659696 SGTC_3253 9135987 49.47 µM -0.166805357945291 0.425635160592424 no 1954 0.433761601362639 2827 4182430 SGTC_983 1491-0821 12.2 µM -0.166864117027978 0.425610715939577 no 1955 0.43373848385373 2850 46495113 SGTC_2332 7982454 138.89 µM -0.168766372242275 0.424819504434141 no 1956 0.432990204962085 2745 2981748 SGTC_3006 9075424 71.4286 µM -0.169747890141795 0.424411376559188 no 1957 0.432604204838348 2722 7465181 SGTC_2996 9066192 71.4286 µM -0.16982349266669 0.424379943404343 no 1958 0.432574475405598 2751 6472854 SGTC_2671 danthron 100 µM -0.169907807462807 0.424344888528114 no 1959 0.432541320467626 2742 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_3116 9124943 49.47 µM -0.170062457834568 0.424280592358084 no 1960 0.432480508847197 2714 41905195 YPL160W CDC60 SGTC_1113 artemisinin 1.17947 µM -0.17039781962891 0.424141172014358 no 1961 0.432348643376124 2757 2240 An anti-malaria and mitochondrial poison. SGTC_1327 1436-0082 2.18 µM -0.17048627554755 0.424104399715217 no 1962 0.432313863444112 2742 15992205 SGTC_3182 9108849 49.47 µM -0.171871338887707 0.423528696877835 no 1963 0.431769339754932 2786 17133045 SGTC_1748 st037455 53.6035 µM -0.17200292462417 0.423474011616666 no 1964 0.431717614874866 2881 580690 SGTC_1433 4060-0023 7.6 µM -0.172292456701131 0.423353691173295 no 1965 0.431603807179435 2831 3840627 SGTC_2938 9059746 27.26 µM -0.175074212814127 0.4221980464566 no 1966 0.430510660250569 2836 6471769 SGTC_1525 8-methoxypsoralen 92.5 µM -0.175850978067764 0.421875468495485 no 1967 0.430205509454711 2952 4114 Related to psoralen; DNA damaging agent. SGTC_1118 chelidonine 707.474 nM -0.176239687757832 0.421714063353185 no 1968 0.430052821206688 2732 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2934 9036370 36.88 µM -0.176549978360799 0.421585229851582 no 1969 0.429930944104043 2828 6462800 SGTC_3332 9141069 11.198 µM -0.177379056529195 0.421241035553785 no 1970 0.429605328465819 2705 17332883 SGTC_2335 9018011 154.17 µM -0.177911248620681 0.421020126100975 no 1971 0.429396338330036 2830 6458208 SGTC_1419 3993-2473 62.6 µM -0.179136714182271 0.420511538025757 no 1972 0.428915177249264 2743 704026 SGTC_2989 9073649 71.4286 µM -0.179478023948366 0.420369912523519 no 1973 0.428781185749183 2697 21367202 SGTC_155 k072-0202 43.6 µM -0.179585541697933 0.420325300477974 no 1974 0.428738978095057 2683 5857737 SGTC_2110 5483698 200 µM -0.181170792401368 0.419667655833351 no 1975 0.428116759748739 2780 2848765 YHR062C RPP1 SGTC_236 1509-0011 5.31 µM -0.181901429070887 0.419364625048094 no 1976 0.427830041486309 2812 3107280 SGTC_944 3370-0224 231 µM -0.183615658552172 0.418653838202145 no 1977 0.427157489116095 2763 4580514 SGTC_1915 st067105 30.6 µM -0.184219687992555 0.418403447018803 no 1978 0.426920557505657 2694 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_761 k216-0224 480 µM -0.184845119726314 0.418144218680946 no 1979 0.426675258589629 2786 1340404 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.185090700840745 0.418042440174167 no 1980 0.426578947622426 2712 88881 An O-methylated flavonoid and antioxidant. SGTC_2795 7780010 54.55 µM -0.186035152223895 0.417651073442595 no 1981 0.426208597497033 2859 953673 SGTC_62 0180-0423 3.232 µM -0.186277748976452 0.417550558073191 no 1982 0.426113477905057 2776 30102 YGL099W LSG1 SGTC_1288 0973-0013 65.5 µM -0.186355961051547 0.41751815352931 no 1983 0.426082812702948 2838 4315430 SGTC_2765 myclobutanil 7.74 µM -0.186358663995447 0.417517033665388 no 1984 0.4260817529472 2834 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_2608 thymoquinone 42.66 µM -0.190413447159165 0.415837843811993 no 1985 0.424492580566524 2704 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1689 st020265 53.493 µM -0.192076742811353 0.415149472717129 no 1986 0.423841046126138 2871 5758320 YPR016C TIF6 SGTC_1219 1469-0211 33.1 µM -0.193688338740776 0.414482746399296 no 1987 0.423209961635696 2828 6822282 SGTC_1442 4112-3290 3 µM -0.193924712408296 0.414384977948511 no 1988 0.423117416648932 2745 704353 SGTC_111 0083-0039 52.457 µM -0.195844149983245 0.413591260573154 no 1989 0.422366076226871 2730 759313 SGTC_1741 st038134 10.228 µM -0.197999400237863 0.412700451739161 no 1990 0.421522766491215 2948 1272587 SGTC_2841 9004761 38.96 µM -0.198284651378291 0.412582585210573 no 1991 0.421411179852381 2769 2991039 SGTC_2964 9083345 53.42 µM -0.199516608375161 0.412073627971281 no 1992 0.420929326454447 2805 17741579 SGTC_82 0054-0107 293.755 µM -0.199813096897806 0.411951161987388 no 1993 0.420813379019103 2834 3104697 SGTC_2204 7233102 200 µM -0.199929998214873 0.411902877702904 no 1994 0.420767664439135 2779 2172480 SGTC_154 3389-1638 511.116 µM -0.201925898858826 0.411078708118974 no 1995 0.419987327370734 2868 5238686 SGTC_3040 9091894 49.47 µM -0.202086277576691 0.411012499729298 no 1996 0.41992463772834 2776 25236966 SGTC_2320 7373003 200 µM -0.203864883718036 0.41027841649159 no 1997 0.419229543743008 2813 5415828 SGTC_824 1304-0008 100 µM -0.203959078647521 0.410239548204687 no 1998 0.419192738593362 2783 768245 SGTC_878 0828-0289 13.7 µM -0.204183435816033 0.410146973750094 no 1999 0.419105077496286 2797 745350 YLR208W SEC13 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.204365262891294 0.410071951773634 no 2000 0.419034036753106 2785 390807 SGTC_457 grayanotoxin iii 135 µM -0.206045847594673 0.409378697515144 no 2001 0.418377549193698 2809 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1800 st050079 29.0735 µM -0.208025789324089 0.408562319770823 no 2002 0.417604415421838 2871 3645560 SGTC_3341 9147222 25.867 µM -0.208712251315277 0.408279367344031 no 2003 0.417336437798693 2899 1939759 SGTC_2379 9035213 200 µM -0.20935376994542 0.408014983318042 no 2004 0.417086039642489 2900 646551 SGTC_2 0422-0095 29 µM -0.210529069325936 0.407530725148665 no 2005 0.416627382989248 2756 6790840 SGTC_190 3970-0790 3.722 µM -0.211094419191727 0.407297834527517 no 2006 0.416406797477233 2783 2832352 SGTC_1318 1280-3875 124 µM -0.212862673328526 0.40656963054596 no 2007 0.415717038750022 2843 373245 SGTC_137 0438-0332 85.389 µM -0.214484172059275 0.405902147309811 no 2008 0.415084754320609 2779 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.214577319840002 0.405863811699006 no 2009 0.415048439097673 2914 521171 SGTC_2776 terbinafine 19.92 µM -0.216257976810914 0.405172281169145 no 2010 0.414393331808143 2771 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_586 0957-0265 8.15 µM -0.216580428414605 0.405039637583223 no 2011 0.414267669792671 2825 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1089 terbinafine 2.25 µM -0.216683781852422 0.404997124454805 no 2012 0.414227393972977 2910 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1923 st058458 19.1 µM -0.216764556983752 0.404963899407478 no 2013 0.414195917325489 3037 3534982 SGTC_3173 9105693 49.47 µM -0.216833244949031 0.40493564668506 no 2014 0.414169151267527 2944 17096658 SGTC_2055 5235184 200 µM -0.21738849203202 0.40470728075211 no 2015 0.413952799399872 2952 2836034 SGTC_1064 honokiol 6.76 µM -0.21745252638275 0.404680946338896 no 2016 0.413927850111559 2874 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1899 st063254 59.6 µM -0.219591091648116 0.403801700507513 no 2017 0.413094814958977 2769 3093813 SGTC_616 4092-0450 108 µM -0.219606228547104 0.403795478876908 no 2018 0.413088920073625 2854 787165 SGTC_1993 st073995 70.8 µM -0.2201132049695 0.403587113407851 no 2019 0.412891495460172 2816 3098394 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.220773362250741 0.403315832181697 no 2020 0.412634452831768 2826 279621 SGTC_546 peri-Naphthalide 147 µM -0.22507295222725 0.401550127223974 no 2021 0.41096126107886 2875 223824 A penicillin ester. SGTC_460 trequinsin 123 µM -0.226201298363689 0.401087082514872 no 2022 0.410522430416453 2874 5537 A vasodilator. SGTC_3250 9135583 49.47 µM -0.227296235586819 0.400637880764728 no 2023 0.410096700039526 2948 7699353 SGTC_285 1486-1325 46 µM -0.227672756342442 0.400483442158424 no 2024 0.409950326764566 2912 22310230 SGTC_488 nitrendipine 139 µM -0.227887228518375 0.400395478439373 no 2025 0.409866955840479 2786 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1606 st000094 49.2 µM -0.228725079137226 0.400051890449441 no 2026 0.409541300555265 2900 1242210 SGTC_1472 k841-0093 193 µM -0.230146112389017 0.399469326375851 no 2027 0.408989116972266 2911 X1472 SGTC_765 1319-0117 244 µM -0.230430262767121 0.399352863434642 no 2028 0.408878723750233 2796 3487746 YGL099W LSG1 SGTC_2767 sibutramine 71.45 µM -0.230552581875626 0.399302732022418 no 2029 0.408831204657065 3000 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2715 st079500 56.4 µM -0.231273999206217 0.399007099268183 no 2030 0.40855097239572 2787 28246688 SGTC_2468 5987765 72.9 µM -0.231694255147823 0.398834907441007 no 2031 0.408387746856645 2865 26772094 SGTC_32 0928-0142 34.1 µM -0.232191389484205 0.398631241585083 no 2032 0.408194682612497 2843 2244242 SGTC_658 3253-0951 102 µM -0.235074780254842 0.397450520854415 no 2033 0.407075346354724 2869 1184878 SGTC_396 dithiazanine 1.25 µM -0.235539614394358 0.397260263362852 no 2034 0.406894967863462 2845 10578 An antihelmenthic. SGTC_1032 k061-1018 98.7 µM -0.237540637296239 0.396441520549238 no 2035 0.406118698581006 3026 4005393 SGTC_171 k064-0041 9.68 µM -0.238459619408078 0.396065660590943 no 2036 0.405762315557783 2838 53325 SGTC_2152 5568786 200 µM -0.239545779788147 0.39562154997954 no 2037 0.405341201194119 2825 5399883 SGTC_3248 9135562 49.47 µM -0.240018756819363 0.3954282008543 no 2038 0.405157857863737 2886 17650701 SGTC_1120 ficusin 1.78878 µM -0.241976817542496 0.394628036040258 no 2039 0.404399063215538 2977 6199 A DNA cross-linker. SGTC_1640 st009078 66.4 µM -0.242633258526292 0.394359879612149 no 2040 0.404144757186972 2965 690618 SGTC_2064 5220758 200 µM -0.244542370177828 0.393580291592772 no 2041 0.40340539557952 3001 788518 SGTC_1641 st009299 47.1 µM -0.245804531522157 0.39306512043519 no 2042 0.402916774511546 2857 4046054 SGTC_1850 st056238 17 µM -0.246761001737389 0.392674846601129 no 2043 0.402546596693507 2804 5393177 SGTC_948 3448-0295 75.3 µM -0.247815928999617 0.392244523919848 no 2044 0.402138414866937 2832 678569 SGTC_862 0452-0056 10.2 µM -0.24970439799737 0.39147451477942 no 2045 0.401407978408605 2875 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1757 st041620 31.8375 µM -0.250201541030999 0.39127187897159 no 2046 0.401215746789905 2915 5289815 SGTC_1403 3909-7815 62.9 µM -0.250496227084713 0.391151778679508 no 2047 0.401101811033814 2820 6615483 SGTC_1191 1487-1166 10.6 µM -0.250525192215063 0.391139974403249 no 2048 0.401090612572751 2968 3955771 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.251825020432849 0.390610353549456 no 2049 0.400588158454715 3006 5377381 SGTC_3245 9134821 49.47 µM -0.251917028832143 0.390572871990831 no 2050 0.400552598439821 2860 17014901 SGTC_2245 6637752 200 µM -0.252682572797777 0.390261050996629 no 2051 0.40025675792835 3006 681890 SGTC_1632 st005650 90 µM -0.253038554857032 0.390116076588558 no 2052 0.400119209981084 2976 2759605 SGTC_2275 7947463 200 µM -0.253092610295344 0.390094063738754 no 2053 0.400098324577383 2914 1225414 SGTC_690 glyoxal 20.3 µM -0.254236274188451 0.38962841529882 no 2054 0.399656514137866 2865 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3133 9127736 49.47 µM -0.255362437091844 0.389170047241481 no 2055 0.399221590037383 2930 27243420 SGTC_510 ag-490 170 µM -0.256800262785786 0.388585051130324 no 2056 0.398666483600172 2926 5328779 SGTC_1848 st056003 16.4 µM -0.257119764440949 0.388455092419942 no 2057 0.398543160259413 2869 146492 SGTC_2793 7325131 81.82 µM -0.257707831134567 0.388215926342647 no 2058 0.398316200918236 2926 4176441 SGTC_2321 7390090 138.78 µM -0.258413487725257 0.387928992534672 no 2059 0.398043904158729 2938 649046 SGTC_2227 7312221 64.1025 µM -0.258753164697706 0.387790895018966 no 2060 0.397912848268003 2856 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1671 st016596 74.5 µM -0.259326768543035 0.387557725489971 no 2061 0.397691563681474 2908 2829167 SGTC_2541 muurolladie-3-one 83.07 µM -0.260245076017202 0.387184518651432 no 2062 0.397337368066551 3036 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_908 3448-7491 47.7 µM -0.261101995023672 0.386836354557858 no 2063 0.397006926613123 2850 1203031 SGTC_148 3253-0744 288.01 µM -0.261419018988012 0.386707571555351 no 2064 0.396884695905513 2842 6893655 SGTC_3073 9114972 49.47 µM -0.261474791859428 0.386684916520717 no 2065 0.39686319334976 2992 41905075 SGTC_1708 st033234 31.827 µM -0.262176716297617 0.386399826663945 no 2066 0.396592601703185 2995 674664 SGTC_3024 9090631 49.47 µM -0.262212808553385 0.386385169283402 no 2067 0.396578689495009 2965 25236383 SGTC_963 1269-2853 151 µM -0.262714324293054 0.38618151614393 no 2068 0.396385387658445 2888 3668223 SGTC_902 1120-0002 2.07 µM -0.262868220842311 0.386119028845734 no 2069 0.396326075610306 2858 3280475 SGTC_800 3448-7362 155 µM -0.264899238945273 0.385294642885955 no 2070 0.395543542315876 2951 15991913 SGTC_1257 0669-0121 16 µM -0.264947148374886 0.385275202789598 no 2071 0.395525088306396 2971 4307855 SGTC_622 1348-1566 26.3 µM -0.265102118734679 0.385212322806529 no 2072 0.395465397601633 2966 7340407 SGTC_1905 st060207 84.5 µM -0.265517690871452 0.385043717276712 no 2073 0.395305341722169 2831 1948547 SGTC_2645 abamectin 100 µM -0.266101097036004 0.384807054961568 no 2074 0.395080675069344 3002 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_340 k038-0059 454 µM -0.267285574060407 0.38432669663201 no 2075 0.394624646540223 2877 23733424 SGTC_1902 st060212 70.5 µM -0.269101873361083 0.383590451325318 no 2076 0.393925644429937 2898 688944 SGTC_987 1497-1013 404 µM -0.270152086398513 0.383164934123127 no 2077 0.393521626044513 2866 1676435 SGTC_2847 9005661 71.43 µM -0.270562898468365 0.382998522780439 no 2078 0.39336361724377 2950 2991449 SGTC_1627 st003713 25.6 µM -0.271086480021119 0.382786462187922 no 2079 0.393162259881351 2961 16195070 YER133W GLC7 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.27142643519314 0.382648792616328 no 2080 0.393031536278626 2901 688664 SGTC_1410 3909-8106 77.9 µM -0.27240041728251 0.3822544471835 no 2081 0.392657075941211 2959 1039210 SGTC_104 0074-0074 590.992 µM -0.274127914172007 0.381555319571331 no 2082 0.39199316138907 2815 3943124 SGTC_1548 st061468 90.8 µM -0.274563535829076 0.381379081952021 no 2083 0.391825792083962 3006 390799 SGTC_1004 4084-0029 199 µM -0.275263386606995 0.381095997778059 no 2084 0.391556945773363 3049 716894 YLR208W SEC13 SGTC_1668 st014914 51.6 µM -0.278772499262171 0.379677551182386 no 2085 0.390209710262111 2948 2839556 SGTC_1166 k206-0078 225 µM -0.279448736116548 0.379404389365691 no 2086 0.389950237049136 2893 5404595 SGTC_1145 3546-0597 10.2 µM -0.27988432370133 0.379228468239204 no 2087 0.38978312731876 2958 875334 SGTC_2411 st077133 39.94 µM -0.280048807255397 0.379162044629454 no 2088 0.38972002980187 3199 1403142 YNL221C POP1 SGTC_1862 st057513 3.81 µM -0.280800725470383 0.378858441967575 no 2089 0.389431623579211 2907 5393163 SGTC_536 3852-0578 10.6 µM -0.28142509085814 0.378606398201085 no 2090 0.389192187862988 3072 2869208 SGTC_2087 5276107 200 µM -0.282603388715405 0.378130883748996 no 2091 0.388740441183079 2882 144405 SGTC_342 k048-0088 23.3 µM -0.284026882934214 0.377556663930323 no 2092 0.388194889523838 2867 6820570 SGTC_1718 roemerine 11.9335 µM -0.284410814816683 0.377401836866014 no 2093 0.388047786022233 3063 235224 An aporphine alkaloid with mutagenic activity. SGTC_1138 3761-0006 1.03 µM -0.2844154912154 0.37739995115006 no 2094 0.388045994359026 2901 12061087 SGTC_567 1080-0542 68.4 µM -0.284474510868788 0.377376152253983 no 2095 0.388023382432622 2936 5950415 SGTC_3043 9092303 49.47 µM -0.287648429338045 0.376096999575071 no 2096 0.386807934796449 2945 25236084 SGTC_1104 tacrolimus 29.8 µM -0.287756634723918 0.376053414533087 no 2097 0.386766517183038 2941 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2988 9073640 71.4286 µM -0.29008984093465 0.375113986391674 no 2098 0.385873753782296 3123 9102229 SGTC_2183 6420625 130.508 µM -0.290769200225939 0.374840592161076 no 2099 0.385613921350205 2904 2897619 SGTC_2544 sphondin 68.51 µM -0.290930930321289 0.374775516459583 no 2100 0.385552072503423 3124 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2073 5212005 126 µM -0.290936646647111 0.374773216433962 no 2101 0.385549886518501 2860 691789 SGTC_3186 9110464 49.47 µM -0.292924703286464 0.373973571011637 no 2102 0.384789853077153 3045 17018021 SGTC_1375 2910-0797 186 µM -0.293219308651667 0.373855119498041 no 2103 0.384677263113518 2983 742508 SGTC_2311 7694451 200 µM -0.296030172983405 0.372725560232296 no 2104 0.383603519416076 2982 2163142 SGTC_304 1310-0298 97 µM -0.299017379871151 0.371526335520815 no 2105 0.382463392337435 2983 1550234 SGTC_1017 4239-0030 168 µM -0.299059583485639 0.371509401629816 no 2106 0.382447291756911 2941 1149593 SGTC_544 k015-0020 52.4 µM -0.299731099819816 0.371239994099045 no 2107 0.382191137198789 2973 3008304 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.300478977019713 0.37094002538823 no 2108 0.38190591494284 3040 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1096 rimcazole 32.2 µM -0.300675240155889 0.370861318494162 no 2109 0.381831075544912 2911 18528119 A dopamine reuptake inhibitor. SGTC_313 3474-0040 5.03 µM -0.303485278132979 0.36973501022948 no 2110 0.380760032561509 2923 1043375 YIL048W NEO1 SGTC_565 1418-0001 44.5 µM -0.303814545339496 0.369603107560584 no 2111 0.380634592326857 3114 2862145 SGTC_2606 farnesol 9.78 µM -0.304410363267137 0.369364465121962 no 2112 0.38040763672977 3116 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1723 st034307 2.5525 µM -0.304855630329896 0.369186155544469 no 2113 0.380238054986608 3020 867466 SGTC_2442 5158906 48.48 µM -0.30563203077739 0.368875309169143 no 2114 0.379942414845965 3075 1893835 SGTC_3339 9145883 14.936 µM -0.306439071880613 0.368552286132734 no 2115 0.379635181616826 3084 2030670 SGTC_3108 9121785 49.47 µM -0.307370798178533 0.368179472604873 no 2116 0.379280576361397 2859 17140271 SGTC_1465 k213-0056 144 µM -0.307610406374728 0.368083617740002 no 2117 0.379189400398021 2920 24048857 YMR208W ERG12 SGTC_2616 abietic acid 100 µM -0.308156821413692 0.367865056029543 no 2118 0.378981503114753 3102 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3313 9133968 57.047 µM -0.30840423408314 0.367766106975857 no 2119 0.378887380279086 2899 1494643 SGTC_3064 1327-0027 10 µM -0.308555320213069 0.367705686618482 no 2120 0.37882990633777 2916 16000455 YPR107C YTH1 SGTC_733 4069-0007 56.1 µM -0.308934542874387 0.367554047355593 no 2121 0.378685659890739 2980 5717425 YNL287W SEC21 SGTC_1290 0986-0249 10.2 µM -0.308999261919574 0.367528170298725 no 2122 0.378661044135054 3010 53329 SGTC_2469 5655019 90.81 µM -0.309763113537569 0.367222799772791 no 2123 0.378370551960473 3078 2788239 SGTC_3152 9099253 49.47 µM -0.310213082547601 0.367042951671092 no 2124 0.378199461254098 3020 25236131 SGTC_1782 st039423 80.636 µM -0.312475432832123 0.366139155745862 no 2125 0.377339615384655 2993 2068169 SGTC_1261 0712-0010 12.7 µM -0.313499655060468 0.365730228600114 no 2126 0.376950541357005 3143 2840123 SGTC_1003 4049-0218 100 µM -0.314141907310567 0.365473883140649 no 2127 0.37670663098026 3111 295161 SGTC_2051 5263410 176 µM -0.314350452665278 0.365390658271261 no 2128 0.376627441562122 3040 227584 SGTC_2952 9073731 13.78 µM -0.314479785962283 0.365339047997829 no 2129 0.37657833337314 2985 16457353 SGTC_2918 7977171 22.06 µM -0.314911607969774 0.36516674768974 no 2130 0.376414383906091 2929 2236483 SGTC_1398 3558-0053 112 µM -0.315453819071624 0.364950439826427 no 2131 0.376208554685906 2905 4532369 SGTC_3008 9078912 71.4286 µM -0.316547338735453 0.364514325576457 no 2132 0.375793549896278 2991 16648731 SGTC_1184 1269-1718 139 µM -0.317831599430725 0.364002364424996 no 2133 0.375306339856793 3110 5403821 SGTC_2675 theaflavin digallate 100 µM -0.318160700282409 0.363871209792287 no 2134 0.375181520826461 3006 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1033 k072-0102 21.3 µM -0.319973631379057 0.363148999250326 no 2135 0.374494159831115 3147 5965931 SGTC_2423 st077119 87.2 µM -0.320176357317161 0.363068270265254 no 2136 0.374417322356448 2971 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_7 0192-1582 4.227 µM -0.32049765609011 0.362940335983421 no 2137 0.374295553453398 3013 252616 SGTC_2690 usnic acid 100 µM -0.320596475789054 0.362900991173039 no 2138 0.37425810433299 3217 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1395 3486-0190 4.35 µM -0.321193227920154 0.362663426608046 no 2139 0.374031981912341 3134 6748079 SGTC_1440 4100-1550 40 µM -0.321618112946113 0.36249431383916 no 2140 0.373871010101337 3008 742806 SGTC_17 0960-0276 49.807 µM -0.322936119858648 0.361969891437147 no 2141 0.373371810463375 2984 6821114 SGTC_1343 1487-0095 224 µM -0.324843387232653 0.36121146677012 no 2142 0.372649802731876 3116 4560101 YGL055W OLE1 SGTC_362 0310-0100 9.03 µM -0.325752982716659 0.360849958040341 no 2143 0.372305627143316 3099 790235 SGTC_2815 7968870 71.43 µM -0.326436815166226 0.360578258171084 no 2144 0.372046943609183 2970 2977326 YHR190W ERG9 SGTC_1329 1447-1697 50.6 µM -0.331985909956035 0.358376108679771 no 2145 0.369949949221142 3076 2840515 SGTC_2917 7979103 53.79 µM -0.332621607610532 0.35812413188491 no 2146 0.369709965372906 3133 2980565 SGTC_976 1348-1067 47.6 µM -0.332800071703208 0.35805340368304 no 2147 0.369642602054416 3002 5310671 YGL099W LSG1 SGTC_319 1348-1596 45.5 µM -0.3329968261598 0.357975432360722 no 2148 0.369568339465219 3176 5380505 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.333362124767676 0.357830684818382 no 2149 0.369430474829481 2993 229346 A bile salt which induces apoptosis. SGTC_2459 5811157 9.22 µM -0.33357743837142 0.357745377573199 no 2150 0.36934922278328 2975 2870684 YBR192W RIM2 SGTC_3272 9137413 49.47 µM -0.334005458851605 0.357575816972306 no 2151 0.369187719715219 2951 17614870 SGTC_3187 9109394 49.47 µM -0.334263090072035 0.357473769739901 no 2152 0.369090519999004 3040 17098090 SGTC_1864 st057645 30.4 µM -0.335235832725219 0.357088560165686 no 2153 0.368723596862043 3063 688666 SGTC_440 fluspirilene 35.1 µM -0.335638787801524 0.356929031148255 no 2154 0.368571635324131 3211 3396 An atypical antipsychotic. SGTC_1806 st050005 60.3 µM -0.337699190268643 0.35611371388957 no 2155 0.367794942512042 3008 5194765 SGTC_1047 2043-3044 82 µM -0.339699499070151 0.355322805016746 no 2156 0.367041419509993 3022 669592 SGTC_1781 st038725 66.3 µM -0.340369819642969 0.355057903832823 no 2157 0.366789021882633 3000 4270275 YIL048W NEO1 SGTC_1897 st060201 15 µM -0.34138691764729 0.354656094924524 no 2158 0.36640616120574 3018 611878 SGTC_1515 3460-0031 42.1 µM -0.341671492256762 0.354543701434737 no 2159 0.366299064113002 3032 2876596 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.342721321091442 0.354129178376912 no 2160 0.365904060602917 3406 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_860 0443-0016 25.1 µM -0.3432272619964 0.353929470179108 no 2161 0.365713748447192 3011 5337942 SGTC_3034 9090421 49.47 µM -0.34473620712338 0.353334088615789 no 2162 0.36514634774464 3050 17173761 SGTC_1927 st060202 13.8 µM -0.344862384758558 0.353284319183794 no 2163 0.365098915184954 3095 688887 SGTC_3139 9095020 49.47 µM -0.344919650509638 0.353261732142421 no 2164 0.365077388586836 2897 25236292 SGTC_1376 2910-0861 41.3 µM -0.345089046680807 0.353194921091105 no 2165 0.365013713865461 2997 1112859 SGTC_503 tyrphostin 8 294 µM -0.345751836787021 0.352933555474641 no 2166 0.364764611935973 3117 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2977 9011197 71.43 µM -0.346688020536129 0.35256449764233 no 2167 0.364412855467401 3206 2704722 SGTC_2322 7413319 38.22 µM -0.347001429310736 0.352440978129883 no 2168 0.364295122489719 3120 1840400 SGTC_1856 st057054 55.7 µM -0.347597483749652 0.352206106293626 no 2169 0.364071248129889 3235 1266018 SGTC_1453 4237-0541 195 µM -0.348191819147104 0.351971967951295 no 2170 0.363848065609941 3151 739892 SGTC_2642 cholecalciferol 100 µM -0.349353135682548 0.351514629491784 no 2171 0.363412105877707 3116 9821465 A vitamin D precursor, similar to steriods. SGTC_1777 st045864 34.765 µM -0.349575888918347 0.351426931502399 no 2172 0.363328504221153 3097 4691462 SGTC_325 2810-4341 181 µM -0.353777363312288 0.349774296264433 no 2173 0.361752869627977 3131 774970 SGTC_2488 5268135 45.7 µM -0.3550785518827 0.349263053266472 no 2174 0.361265372096286 3159 1270356 YLR208W SEC13 SGTC_2829 7992743 58.44 µM -0.355080337109774 0.349262352030108 no 2175 0.361264703405561 3176 16462845 SGTC_2254 7938975 95.19 µM -0.356086641499228 0.348867158094753 no 2176 0.360887840490834 3206 2969277 SGTC_1299 1079-1439 3.74 µM -0.356792049697167 0.348590229220415 no 2177 0.360623744250199 3049 323161 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.357742375182369 0.348217278371534 no 2178 0.360268059058966 3260 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2929 9013348 24.6 µM -0.35873533502422 0.347827752613387 no 2179 0.359896545963299 3129 2995952 SGTC_1309 pyrazolanthrone 13.4 µM -0.359770495384491 0.347421843051075 no 2180 0.35950938453613 3141 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_483 fpl-64176 144 µM -0.360752224894853 0.347037046505318 no 2181 0.359142340022678 3075 3423 SGTC_3001 9076041 71.4286 µM -0.36166511563108 0.346679373314401 no 2182 0.358801149246167 3021 16004211 SGTC_194 1486-1323 56.904 µM -0.362213281926632 0.346464665824506 no 2183 0.358596327480731 3093 5178754 SGTC_1971 st069429 63.5 µM -0.363497671031672 0.345961785546179 no 2184 0.358116576183741 3167 1246522 YGL099W LSG1 SGTC_2943 9068529 45.32 µM -0.363821916242516 0.345834875855477 no 2185 0.357995497901948 3038 3270634 SGTC_2007 4011539 71.82 µM -0.364894358493825 0.345415245017376 no 2186 0.35759513283289 3016 45595301 SGTC_348 k064-0012 10.7 µM -0.366363876444217 0.344840552816828 no 2187 0.357046785577397 2997 5066323 SGTC_1078 idebenone 36.1 µM -0.367307158528723 0.344471846930828 no 2188 0.356694957493111 3114 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2248 tofa 1.1 µM -0.367582687405914 0.344364177296952 no 2189 0.356592212921716 2989 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1704 st028805 70.8 µM -0.368192604131093 0.344125882317733 no 2190 0.356364812320499 3123 2876101 SGTC_1558 st069300 45.6 µM -0.368378597154038 0.344053226995336 no 2191 0.356295477066976 3165 24208000 SGTC_13 0199-0087 65 µM -0.370255031551603 0.343320549088577 no 2192 0.355596238107137 3080 4589825 SGTC_2932 9016711 44.54 µM -0.372078093926146 0.342609274471493 no 2193 0.354917352915918 3193 7117328 SGTC_1771 st048882 4.1505 µM -0.374815172638632 0.341542440705736 no 2194 0.353898964704564 3047 4580403 SGTC_1350 1495-0454 146 µM -0.376269435687621 0.340976125124809 no 2195 0.353358299665441 3219 1069057 SGTC_202 3594-0513 34.79 µM -0.377630974325985 0.340446242591573 no 2196 0.35285237571472 3078 708429 SGTC_1011 4112-3381 17.4 µM -0.378608797683376 0.340065888231372 no 2197 0.35248919405608 3233 2877139 SGTC_2701 st077767 14.721 µM -0.379065765011612 0.33988819254864 no 2198 0.35231951402168 3110 5721188 SGTC_2532 xanthone 78.9 µM -0.379462845285106 0.339733813343422 no 2199 0.352172094971163 3173 7020 An insecticide. SGTC_1312 1218-2183 165 µM -0.383366781794307 0.33821745269748 no 2200 0.350723914820653 3132 6744073 SGTC_1623 st003709 20.3 µM -0.384013991198379 0.33796631724986 no 2201 0.350484038804235 3066 16192618 SGTC_2261 9010538 184.68 µM -0.384274435910754 0.337865277716654 no 2202 0.350387526676343 3170 6457250 SGTC_290 2043-6722 48.1 µM -0.38516726163923 0.337518994652305 no 2203 0.35005674856844 3180 773758 YLR208W SEC13 SGTC_909 3448-9333 149 µM -0.385247525886669 0.3374878708436 no 2204 0.350027017475965 3058 3344074 SGTC_1835 st008666 49.2 µM -0.385979669040285 0.337204021395076 no 2205 0.349755863026056 3057 690455 SGTC_3330 9141424 71.43 µM -0.386023048291851 0.337187206310254 no 2206 0.349739799613167 3209 27261020 SGTC_798 1287-0182 476 µM -0.386065015556383 0.337170938863039 no 2207 0.349724259317548 3248 1649755 SGTC_1843 st055809 45.5 µM -0.386183226047214 0.337125119478393 no 2208 0.349680487840166 3218 16413835 SGTC_1100 amiodarone 5.07 µM -0.386594437188891 0.33696574939133 no 2209 0.349528238418882 3178 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1239 0337-0584 35.4 µM -0.387442156125427 0.33663729754749 no 2210 0.349214449979641 3249 914301 YML130C ERO1 SGTC_625 k213-0058 121 µM -0.388062740486721 0.336396928804748 no 2211 0.348984802135087 3156 3655420 SGTC_54 0159-0055 9 µM -0.38817467653896 0.336353580123816 no 2212 0.348943385974935 3310 3319099 SGTC_3261 9137475 49.47 µM -0.389520549091772 0.335832544071551 no 2213 0.348445556305346 3119 17027690 SGTC_700 3453-2283 142 µM -0.389804525595534 0.335722646733352 no 2214 0.348340548517334 3255 565664 SGTC_2720 fluspirilene 36.88 µM -0.390324030738535 0.335521637475334 no 2215 0.348148477901136 3165 3396 An atypical antipsychotic. SGTC_3180 9109287 49.47 µM -0.39104720009388 0.335241903915376 no 2216 0.347881173721967 3203 18891271 SGTC_2418 pentamidine 31.67 µM -0.391848953119138 0.334931879691782 no 2217 0.347584911111755 3193 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2864 9034755 47.6 µM -0.392357144245908 0.334735429062372 no 2218 0.34739717324428 3175 4930451 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.392716028012288 0.334596723182549 no 2219 0.347264615607944 3274 5393153 SGTC_3067 9117431 49.47 µM -0.394698939189534 0.3338307502199 no 2220 0.346532542873921 3110 17150885 SGTC_478 N-arachidonylglycine 10 µM -0.395618883306059 0.333475622452223 no 2221 0.346193102236158 3166 5283389 SGTC_1628 st004252 77.7 µM -0.396458895711969 0.333151481163457 no 2222 0.34588326264934 3222 692968 SGTC_1328 1441-0025 69.2 µM -0.397039459718642 0.332927527787022 no 2223 0.345669181198011 3076 4562601 SGTC_90 0870-0863 4.608 µM -0.397239256471591 0.332850469687535 no 2224 0.345595518079617 3065 1738164 SGTC_59 0330-0160 1.33 µM -0.397424488650045 0.332779035194794 no 2225 0.345527230000518 3157 4293482 SGTC_2401 5128683 200 µM -0.397441215432017 0.332772584836909 no 2226 0.345521063717818 3093 708373 SGTC_552 k242-0005 476 µM -0.397578687032703 0.332719573465199 no 2227 0.345470386739 3229 4088318 SGTC_2216 7189485 200 µM -0.397870212264151 0.332607167477688 no 2228 0.345362929213892 3207 731273 SGTC_2910 7948405 25.97 µM -0.400888200559776 0.331444380639794 no 2229 0.344251218786705 3253 2971328 SGTC_3160 9100216 49.47 µM -0.402150105609071 0.330958667504263 no 2230 0.343786779706653 3160 17191039 SGTC_1786 berberine 21.6 µM -0.403757959719284 0.330340209030509 no 2231 0.343195356930765 3156 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3246 9135460 32.98 µM -0.406796268427062 0.329172794054916 no 2232 0.342078813835362 3189 41446951 SGTC_3310 9130229 44.1445 µM -0.407621487901432 0.328856005290257 no 2233 0.341775793084338 3236 7761258 SGTC_1682 st012968 530 nM -0.40807611688682 0.328681532874122 no 2234 0.341608896760149 3102 24207270 SGTC_346 4513-0042 7.16 µM -0.40842116193462 0.328549140272549 no 2235 0.341482249851351 3071 2827372 SGTC_2390 9097792 176.6 µM -0.41007499605505 0.327914868816893 no 2236 0.340875467017497 3144 4497149 SGTC_849 0386-0493 241 µM -0.410098371079944 0.327905907677189 no 2237 0.34086689379174 3107 726119 SGTC_844 0330-0132 15.3 µM -0.410717864500102 0.327668452413099 no 2238 0.340639713004123 3241 2828079 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.411437482024709 0.327392706506313 no 2239 0.340375887246253 3164 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1326 1431-2094 10.8 µM -0.411773679765119 0.327263913176728 no 2240 0.340252657387006 3054 616278 SGTC_1756 st041558 35.5 µM -0.413296095198471 0.326680951617338 no 2241 0.339694845199938 3303 3955792 SGTC_2115 tiliquinol 12.7705 µM -0.413396645285442 0.32664246396713 no 2242 0.339658016043105 3182 71208 A bioactive hydroxyquinoline. SGTC_2080 5212524 12.4 µM -0.413579218950596 0.326572584792127 no 2243 0.339591147472046 3250 260183 SGTC_2986 9022445 71.43 µM -0.413745777638798 0.326508840578386 no 2244 0.339530148875065 3265 6459286 SGTC_1384 3089-0840 101 µM -0.415043136879185 0.326012497550748 no 2245 0.33905516248577 3238 1069836 SGTC_1444 4112-3581 28 µM -0.415831544153949 0.325711019555567 no 2246 0.338766637364994 3151 2877249 SGTC_2226 7298446 200 µM -0.418435978559898 0.324715924223905 no 2247 0.337814192940902 3235 3283010 SGTC_102 gallobenzophenone 83.616 µM -0.418664778501969 0.324628564570671 no 2248 0.337730570052976 3307 70837 SGTC_1762 st045503 25.4615 µM -0.420633424355678 0.323877301610903 no 2249 0.337011391364067 3210 4645554 SGTC_2839 9003951 25.97 µM -0.420819713951904 0.323806247962716 no 2250 0.336943367507572 3251 2990634 SGTC_805 3852-0218 479 µM -0.420845015419994 0.32379659809821 no 2251 0.336934129059181 3119 6615355 SGTC_2860 9025725 38.96 µM -0.421331839922028 0.32361094852514 no 2252 0.336756391616645 3084 40546248 SGTC_1637 st007924 17.4 µM -0.423264175066615 0.322874489518449 no 2253 0.336051264562369 3121 683336 SGTC_952 1185-0122 232 µM -0.423610707481075 0.322742491061004 no 2254 0.335924872561957 3134 678600 SGTC_83 0170-0301 39.027 µM -0.423642261016601 0.322730473040399 no 2255 0.335913364850048 3212 3089716 SGTC_2461 5755302 26.15 µM -0.423754553966263 0.322687704724117 no 2256 0.335872412369864 3272 2788904 SGTC_1351 1496-0003 46.5 µM -0.425137750811962 0.322161087691277 no 2257 0.33536812978902 3282 3891978 SGTC_612 0302-0167 22.4 µM -0.426007731644327 0.321830047319086 no 2258 0.335051106086774 3206 235821 SGTC_161 4065-0411 162.148 µM -0.426422833110316 0.321672144969779 no 2259 0.334899883215982 3243 1906281 YLR208W SEC13 SGTC_412 gemfibrozil 100 µM -0.427182173582718 0.321383379327473 no 2260 0.334623322187134 3221 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_708 3448-5400 146 µM -0.427269083077873 0.321350335847159 no 2261 0.334591674410759 3253 3462195 SGTC_3030 9087619 49.47 µM -0.428995698950227 0.320694160117687 no 2262 0.333963177368602 3195 25236973 SGTC_828 2074-0507 139 µM -0.429289186145226 0.320582680111982 no 2263 0.333856392754272 3291 X828 SGTC_2493 resveratrol 26.09 µM -0.430018043894651 0.320305896254908 no 2264 0.33359125781103 3126 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2197 6588183 93.1375 µM -0.430860730141362 0.319986010577477 no 2265 0.333284819302092 3151 884136 SGTC_2697 mebhydrolin 72.4 µM -0.432636817551534 0.319312242003924 no 2266 0.332639318793764 3332 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2070 5230947 200 µM -0.43331838920244 0.319053842215868 no 2267 0.332391740212611 3280 2835538 SGTC_2524 avocatin b 10.57 µM -0.43437001714327 0.318655317892924 no 2268 0.332009883402611 3213 6710748 SGTC_115 0527-0192 112.043 µM -0.434503533941917 0.318604735433401 no 2269 0.331961414562831 3267 4233931 SGTC_1134 3477-0009 42.5 µM -0.435345127462229 0.318285977954933 no 2270 0.331655966731592 3365 3973534 SGTC_67 0335-0847 266 µM -0.43556122321212 0.318204152372751 no 2271 0.331577555017765 3417 4552207 YOR254C SEC63 SGTC_2286 7945697 125 µM -0.435794327299077 0.318115896456358 no 2272 0.331492979995156 3219 1245733 SGTC_2263 7948595 193.29 µM -0.436890057777163 0.317701178584399 no 2273 0.331095541300504 3142 2971371 SGTC_3307 9126885 69.2785 µM -0.437333877519917 0.317533264362833 no 2274 0.330934614996798 3163 24824909 SGTC_1696 st025591 34.7925 µM -0.437442908311612 0.317492019527504 no 2275 0.330895085881433 3165 2787147 SGTC_3062 9077494 49.47 µM -0.437481100680488 0.31747757242019 no 2276 0.330881239683298 3270 16459633 SGTC_2707 st078556 66.6 µM -0.437716082955904 0.317388691301011 no 2277 0.330796054689543 3223 17250899 SGTC_1662 st014054 52 µM -0.438666393834928 0.317029347389128 no 2278 0.330451640549815 3201 2838777 SGTC_281 1672-3440 14.9 µM -0.438898261975596 0.316941696556286 no 2279 0.330367628070571 3273 6833000 SGTC_1324 1418-0026 34.4 µM -0.439125067512054 0.316855969428002 no 2280 0.330285458189308 3255 1372513 SGTC_2928 9011484 9.79 µM -0.440027972454108 0.316514790235735 no 2281 0.329958423921554 3279 2994751 SGTC_933 2914-0560 114 µM -0.440853562498621 0.316202962480558 no 2282 0.329659506980631 3320 463887 SGTC_2778 tioconazole 65.09 nM -0.441156261434976 0.316088664941025 no 2283 0.329549937650619 3222 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_386 1509-0011 3.07 µM -0.441171412651606 0.316082944382424 no 2284 0.329544453679279 3191 3107280 SGTC_2213 7173844 200 µM -0.441697408346199 0.315884374489108 no 2285 0.329354092670484 3192 892728 SGTC_859 0439-0102 54.6 µM -0.44222238171285 0.315686243498395 no 2286 0.329164145741071 3298 610143 SGTC_732 3970-1727 52.7 µM -0.44234294371205 0.315640749487962 no 2287 0.329120529977874 3275 1275699 SGTC_2120 5538279 151.968 µM -0.445100909241894 0.314600796606569 no 2288 0.328123415886316 3209 2058197 SGTC_448 monastrol 171 µM -0.445494417394551 0.314452535085586 no 2289 0.327981246637191 3227 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2837 9008476 45.46 µM -0.445591954350135 0.314415790848488 no 2290 0.327946011688906 3333 2992805 SGTC_219 mitoxanthrone 164.414 µM -0.445691705341483 0.314378214438802 no 2291 0.327909978510362 3219 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3271 9137798 49.47 µM -0.446329513975145 0.314137996052325 no 2292 0.327679619959384 3264 6498326 SGTC_143 4032-1194 15.74 µM -0.447352207032596 0.313752982659318 no 2293 0.327310388859872 3140 1806963 SGTC_1380 2291-0730 164 µM -0.448533516082365 0.313308507425799 no 2294 0.326884101580595 3247 2999191 SGTC_1785 bathophenanthroline 24 µM -0.45057404422519 0.312541384091196 no 2295 0.326148288606896 3184 72812 An iron chelator. SGTC_1679 SEC14.276 6.7 µM -0.451986795420511 0.312010744605323 no 2296 0.325639247549317 3281 1005053 YMR079W SEC14 SGTC_444 curcumin 90.4 µM -0.452729964906511 0.311731761228614 no 2297 0.325371599859483 3310 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_47 0149-0135 24.25 µM -0.453163288375254 0.311569142865628 no 2298 0.325215582757807 3180 5239155 SGTC_3123 9126162 49.47 µM -0.453717116816285 0.311361354691862 no 2299 0.325016222722333 3159 25239884 SGTC_1139 k015-0024 46.9 µM -0.456029793050758 0.310494322927864 no 2300 0.324184277137335 3305 2766652 SGTC_2434 5670830 169.91 µM -0.457461890346206 0.309957950760983 no 2301 0.323669544144257 3278 1549830 SGTC_866 0495-0101 262 µM -0.457477631000658 0.309952057561204 no 2302 0.323663888415352 3196 635694 SGTC_611 3453-1652 23.7 µM -0.459059441506954 0.309360087098349 no 2303 0.323095740545648 3323 1560575 SGTC_3094 9117742 49.47 µM -0.459496000278319 0.309196798075642 no 2304 0.322939011818772 3185 17149698 SGTC_1255 0566-0045 221 µM -0.460162184167579 0.308947693453509 no 2305 0.322699906098678 3358 2788469 SGTC_1812 st052057 4.327 µM -0.462210649123986 0.30818226635032 no 2306 0.321965133645639 3194 3645418 SGTC_1550 gossypolone 36.6 µM -0.462384873904232 0.30811720412592 no 2307 0.321902672283384 3244 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_721 1187-1332 279 µM -0.463229782777484 0.307801768249266 no 2308 0.321599835221572 3190 25730 SGTC_1642 st009582 77.7 µM -0.463367386016322 0.307750409287177 no 2309 0.321550525900069 3351 6739311 SGTC_1136 pergolide 1.05886 µM -0.46451638043596 0.307321706322908 no 2310 0.321138913220418 3168 47811 A dopamine receptor agonist. SGTC_3255 9139072 49.47 µM -0.466803632492136 0.306469090074495 no 2311 0.320320188364782 3299 17646060 SGTC_1359 1582-0056 520 nM -0.469041903920667 0.305635745253224 no 2312 0.319519841985144 3315 3661189 SGTC_1979 st071809 45.3 µM -0.469224716223105 0.305567725633124 no 2313 0.319454510218447 3356 4976333 SGTC_2740 felodipine 17.08 µM -0.470973889688032 0.30491724398279 no 2314 0.318829690386212 3280 3333 L-type calcium channel blocker SGTC_2890 9046729 58.44 µM -0.471246966289297 0.304815747951543 no 2315 0.318732191466971 3196 903329 SGTC_2566 crystal violet carbinol 226 nM -0.471504221968575 0.304720145916144 no 2316 0.318640352706061 3325 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1940 st075990 51.1 µM -0.472302841068164 0.304423445945102 no 2317 0.318355321381409 3460 1084979 SGTC_2946 9065502 71.43 µM -0.472338948341591 0.304410034545096 no 2318 0.318342437045821 3229 16489101 SGTC_2584 androsterone 48.74 µM -0.472460103375182 0.304365035599742 no 2319 0.318299206306303 3323 2754130 A steroid. SGTC_1617 st002906 78 µM -0.475669777280896 0.303173990874027 no 2320 0.317154827805975 3277 5150859 SGTC_1861 st057647 17.4 µM -0.476077827951718 0.303022721011735 no 2321 0.317009466140254 3387 688668 SGTC_2650 prasterone 100 µM -0.476099857246732 0.303014555417204 no 2322 0.317001619351809 3295 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3263 9137018 49.47 µM -0.476931930767613 0.302706203009519 no 2323 0.316705296804104 3285 43844957 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.477203626651049 0.302605547551117 no 2324 0.316608564443411 3343 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.477754149249334 0.302401640869517 no 2325 0.316412599375458 3277 6312947 SGTC_1237 0330-0133 46.1 µM -0.478454895011283 0.302142182585208 no 2326 0.316163235138631 3242 X1237 YHR072W ERG7 SGTC_1935 st074532 41.6 µM -0.478591637610575 0.302091563894878 no 2327 0.316114584276512 3329 2829742 SGTC_2689 tacrolimus 100 µM -0.479336926270565 0.301815743629687 no 2328 0.315849478298337 3296 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2870 9038528 12.99 µM -0.480517779526987 0.301378959285139 no 2329 0.315429631934126 3349 6463316 SGTC_1875 nocodazole 6 µM -0.480974227165155 0.301210200725129 no 2330 0.315267408097211 3367 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_287 k060-0039 29.6 µM -0.481791779801778 0.30090804029419 no 2331 0.314976934717675 3363 5861974 SGTC_1943 st076331 65.2 µM -0.483228664811203 0.300377311465178 no 2332 0.31446669216554 3364 24208415 SGTC_2505 galangin 7.89 µM -0.483776207649519 0.300175182023337 no 2333 0.314272351066735 3176 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1060 3448-7350 82 µM -0.484163124488782 0.300032385940512 no 2334 0.314135052492626 3355 570178 SGTC_3020 9089140 49.47 µM -0.484193109705711 0.30002132083665 no 2335 0.314124413224106 3362 17217859 SGTC_276 colchicine 750 µM -0.484558479535836 0.299886507394011 no 2336 0.313994786161159 3391 2833 A microtubule depolymerizer. SGTC_747 3448-8087 38.7 µM -0.485316125494968 0.299607040099322 no 2337 0.313726059278169 3269 5168703 SGTC_3050 9093513 49.47 µM -0.486538754488441 0.299156306986202 no 2338 0.313292617529526 3318 25236664 SGTC_1792 st045773 43.6 µM -0.486607069642363 0.299131131074694 no 2339 0.313268406301775 3258 2919270 SGTC_1160 4092-0570 10.5 µM -0.486916440780579 0.299017131802479 no 2340 0.313158773719782 3254 4994975 SGTC_938 3126-1755 342 µM -0.487093560836907 0.298951874229204 no 2341 0.313096014699489 3381 1777771 SGTC_1670 st016595 4.04 µM -0.487764455174856 0.298704750642064 no 2342 0.312858345547559 3329 597879 SGTC_808 0711-0032 135 µM -0.488244874070277 0.298527845668812 no 2343 0.312688201467946 3333 4252555 SGTC_1382 3002-2117 298 µM -0.490351163549349 0.29775280843585 no 2344 0.311942714101017 3412 1497314 SGTC_864 0469-0573 172 µM -0.490544071375113 0.297681871341474 no 2345 0.311874475901314 3278 689425 SGTC_769 0302-0231 76 µM -0.490836979918981 0.297574176196302 no 2346 0.311770876319692 3353 571869 YER009W NTF2 SGTC_2953 9074162 66.49 µM -0.491816259470543 0.297214248795038 no 2347 0.311424620570089 3338 16451992 SGTC_1477 0139-0234 16 µM -0.494467973206051 0.296240630170773 no 2348 0.310487859669492 3333 620880 SGTC_2525 harmine 47.85 µM -0.494685257137781 0.296160915825731 no 2349 0.31041115493832 3264 5280953 A monoamine oxidase inhibitor SGTC_332 4112-0506 40.9 µM -0.495307499141701 0.295932690114561 no 2350 0.310191539098288 3287 2790355 SGTC_3107 9121808 49.47 µM -0.495636278062137 0.295812133310455 no 2351 0.31007552626489 3344 662681 SGTC_2327 6189656 200 µM -0.495720341423409 0.295781312540916 no 2352 0.310045866726044 3344 5349088 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.496354458294795 0.295548869152763 no 2353 0.309822175156733 3268 115019 SGTC_2129 girgensonine 121.053 µM -0.49664616102687 0.295441970118416 no 2354 0.309719297505687 3291 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1152 3909-8331 15.9 µM -0.497200909330555 0.295238723003142 no 2355 0.309523690130716 3277 16001939 SGTC_1093 fluphenazine 7.97 µM -0.497472246193706 0.295139334814702 no 2356 0.309428034867984 3315 6602611 An atypical antipsychotic. SGTC_1768 st044301 37.178 µM -0.498377516481199 0.294807854162257 no 2357 0.309108990426936 3290 3931349 SGTC_770 0389-1121 67.2 µM -0.499511178461197 0.294392986091139 no 2358 0.308709656866828 3446 6753108 SGTC_393 acivicin 6.25 µM -0.499869029336726 0.29426208514573 no 2359 0.308583650465022 3226 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2125 5246583 200 µM -0.499884455262067 0.294256442985741 no 2360 0.308578219196905 3436 835267 SGTC_2804 7954240 19.48 µM -0.500693195961835 0.293960709386774 no 2361 0.30829353077149 3380 828705 SGTC_381 3461-2219 42.7 µM -0.502569972200214 0.293274955465446 no 2362 0.307633322696152 3364 2883159 SGTC_1673 st016611 27.3 µM -0.503645516347592 0.292882297689191 no 2363 0.307255250668911 3400 5226799 SGTC_1188 1403-0014 4.57 µM -0.504128098926859 0.292706196625982 no 2364 0.307085681222378 3305 9614867 SGTC_1934 st074720 32.6 µM -0.504873419727772 0.292434315417512 no 2365 0.306823872106623 3274 17250992 SGTC_2208 7283366 200 µM -0.507313528274487 0.291545024908848 no 2366 0.305967423952485 3390 898663 SGTC_3095 9117207 49.47 µM -0.507821338752699 0.291360113499261 no 2367 0.305789321775676 3343 17015229 SGTC_1231 0242-0792 125 µM -0.508103140365311 0.29125752337382 no 2368 0.305690506523418 3282 3707635 SGTC_2132 5317594 122.667 µM -0.508139195822159 0.291244398569789 no 2369 0.305677864504163 3260 794577 SGTC_2413 inermin 26.06 µM -0.510487549792432 0.290390152719991 no 2370 0.304854967402673 3491 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_1271 0832-2808 169 µM -0.511900949714664 0.289876575333476 no 2371 0.304360166730964 3413 3663794 SGTC_294 k038-0071 157 µM -0.512438696316749 0.289681289994918 no 2372 0.304172007242992 3353 24152826 SGTC_344 k064-0035 6.43 µM -0.513111879571601 0.289436907235094 no 2373 0.303936531055664 3256 5088750 SGTC_2131 toluylene red 5.2905 µM -0.513591180456704 0.289262967784744 no 2374 0.30376892352559 3302 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.513693536534165 0.289225828884017 no 2375 0.30373313580194 3383 4213774 SGTC_1289 0976-0073 69.1 µM -0.514012562555048 0.28911008779838 no 2376 0.303621603789694 3394 3391136 SGTC_1119 parthenolide 318.541 nM -0.51464641769249 0.288880192895067 no 2377 0.303400061281696 3456 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_490 phenamil 164 µM -0.515916155404543 0.288419926728175 no 2378 0.302956485061556 3326 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1616 st002734 56.1 µM -0.515999800434223 0.288389618450772 no 2379 0.302927274300909 3271 4026101 SGTC_1226 3909-7979 35.4 µM -0.516479550106873 0.288215813028088 no 2380 0.302759759081186 3406 6615510 SGTC_3331 9141060 1.957 µM -0.517984238325414 0.2876710099687 no 2381 0.302234633217895 3297 4906567 YPR165W RHO1 SGTC_3283 9109332 35.8195 µM -0.518328968822381 0.287546261816994 no 2382 0.302114382212021 3277 17027281 SGTC_3075 9116269 49.47 µM -0.518452980227454 0.287501391876344 no 2383 0.302071129047325 3449 17015205 YNL244C SUI1 SGTC_81 0411-0046 9.971 µM -0.519684085877108 0.28705613157638 no 2384 0.301641890294973 3328 12925265 SGTC_1908 st060353 56.5 µM -0.520085218357602 0.28691112250318 no 2385 0.301502090245429 3470 4227716 SGTC_1770 st043884 66.3 µM -0.520533826160435 0.286748992262325 no 2386 0.301345778953995 3381 670149 SGTC_1353 1498-1206 8.11 µM -0.521927667696594 0.286245524736952 no 2387 0.300860346781591 3440 6756808 SGTC_2927 9011802 47.9 µM -0.523712248524963 0.285601532275353 no 2388 0.300239347544968 3394 43912568 SGTC_2048 5246248 200 µM -0.524924963272135 0.28516430002179 no 2389 0.299817677493223 3428 677046 SGTC_1810 st050138 53 µM -0.528714226347269 0.283800178480399 no 2390 0.298501853404559 3405 3444541 SGTC_3178 9107506 49.47 µM -0.529042258880187 0.283682235000653 no 2391 0.298388067556609 3440 8897194 SGTC_847 0342-0274 5.54 µM -0.529682630769133 0.283452058165976 no 2392 0.29816599631477 3405 18097 SGTC_3019 9081971 49.47 µM -0.529683347647141 0.283451800539767 no 2393 0.298165747754559 3480 16451803 SGTC_2973 9094665 17.96 µM -0.529895025415462 0.283375734290662 no 2394 0.298092357707191 3463 25237061 YIL048W NEO1 SGTC_810 3825-7150 143 µM -0.53200339840757 0.282618626725393 no 2395 0.297361820885394 3453 22330411 YGL099W LSG1 SGTC_1814 st052110 31.539 µM -0.532386309943338 0.282481229253838 no 2396 0.297229232462373 3430 674163 SGTC_1491 4138-0063 26.5 µM -0.532657312553116 0.282384006695752 no 2397 0.297135410386772 3393 23883227 SGTC_790 1575-0012 79.1 µM -0.534017620432937 0.281896237700246 no 2398 0.29666467161269 3457 378741 YLR208W SEC13 SGTC_1997 st073024 93.8 µM -0.534178504997038 0.281838575775166 no 2399 0.296609019601871 3427 686268 SGTC_2779 methotrexate 400 µM -0.534386242641966 0.281764129853356 no 2400 0.296537167591006 3460 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_994 3910-0338 138 µM -0.534552839193657 0.281704434312965 no 2401 0.296479551167794 3481 3479481 SGTC_3316 9136639 10.545 µM -0.534676289904029 0.281660202895909 no 2402 0.296436859785923 3425 4903665 SGTC_463 ikarugamyin 104 µM -0.534823924053383 0.281607311140484 no 2403 0.296385809054235 3403 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3215 9129942 49.47 µM -0.535236733815121 0.281459442377557 no 2404 0.296243084069229 3400 17682944 SGTC_1870 st057514 26.5 µM -0.537016038680036 0.280822523139887 no 2405 0.295628267683483 3318 5393161 SGTC_320 4092-0846 5.34 µM -0.537185593236749 0.280761865846618 no 2406 0.295569710863405 3378 1359356 SGTC_2900 5328528 85.29 µM -0.539962812847707 0.279769232326541 no 2407 0.294611339143976 3425 795359 SGTC_1494 4358-1428 177 µM -0.542155910037719 0.278986580845422 no 2408 0.293855552760673 3470 1564571 SGTC_3266 9136860 49.47 µM -0.542464384491576 0.27887658093264 no 2409 0.293749318108375 3393 4871271 YPR165W RHO1 SGTC_1487 3970-0795 2.82 µM -0.543129732899981 0.27863939404308 no 2410 0.293520241162298 3440 3765103 SGTC_2972 9093619 59.92 µM -0.543225898702245 0.278605120480298 no 2411 0.293487138483638 3289 25236256 SGTC_722 3534-0461 190 µM -0.543727344940987 0.278426437943042 no 2412 0.293314556146226 3402 658262 SGTC_2140 5586273 200 µM -0.544081872858023 0.278300141161509 no 2413 0.293192566954958 3421 854421 SGTC_2971 9092186 9.93 µM -0.544860939328295 0.278022705211137 no 2414 0.292924581350891 3301 25236400 SGTC_1612 st002233 45.4 µM -0.544869368107426 0.278019704348626 no 2415 0.292921682616033 3459 1035021 SGTC_177 1327-0068 8.361 µM -0.5452630762836 0.277879551707723 no 2416 0.292786297580461 3426 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_776 4476-4378 112 µM -0.545477526597438 0.277803225976487 no 2417 0.292712566446115 3435 2892008 SGTC_2350 9023895 38.85 µM -0.546144911278696 0.277565760371117 no 2418 0.292483165088315 3446 2997209 SGTC_1933 st074711 15.9 µM -0.546931260943999 0.277286092561179 no 2419 0.292212978964426 3423 17250958 SGTC_928 2764-0428 58.7 µM -0.547245096961001 0.27717451425312 no 2420 0.292105178783503 3434 662578 SGTC_2289 7946404 165.07 µM -0.548394071645083 0.276766206114974 no 2421 0.291710673108918 3388 1246120 YPR165W RHO1 SGTC_51 1013-0126 23.419 µM -0.549332225181733 0.276433035605606 no 2422 0.291388738101754 3569 1627850 SGTC_2787 5284540 71.43 µM -0.549404249190682 0.276407465540874 no 2423 0.29136402933135 3372 736958 SGTC_1701 st028638 40.4 µM -0.549592384217812 0.276340679052623 no 2424 0.291299491782949 3462 3490878 SGTC_140 0062-0056 502.533 µM -0.551369994589876 0.27571003208438 no 2425 0.290690032672991 3369 3758964 SGTC_1926 methyl fluorone black 53.6 µM -0.551754360616308 0.275573762734262 no 2426 0.290558330074748 3341 72721 Reacts with homocysteine. SGTC_677 0929-0063 136 µM -0.552452072964329 0.275326487319831 no 2427 0.290319331071677 3413 1539583 SGTC_142 0335-0849 62.6745 µM -0.55467271308946 0.274540200467111 no 2428 0.289559271783682 3494 3889043 YPR107C YTH1 SGTC_1493 4348-0038 111 µM -0.554810929726252 0.27449129720652 no 2429 0.289511995228612 3470 800424 SGTC_2656 pseudo-anisatin 100 µM -0.558390438678488 0.273226308796428 no 2430 0.288288900188509 3431 6708809 A neurotoxin. SGTC_1960 st011366 51.8 µM -0.558645026543559 0.27313644829107 no 2431 0.28820200206326 3454 3972846 SGTC_328 k915-0120 63.5 µM -0.558959812216731 0.273025360343412 no 2432 0.288094573790297 3458 6624543 SGTC_3347 9188721 44.724 µM -0.559828084000073 0.2727190631393 no 2433 0.287798352898903 3451 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_166 k072-0058 166.424 µM -0.559858144643657 0.272708461805615 no 2434 0.287788099942388 3487 5846229 SGTC_277 nystatin 15.5 µM -0.560251943545468 0.272569601646959 no 2435 0.287653800625956 3347 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_956 1185-0240 191 µM -0.560838610072004 0.272362798217948 no 2436 0.287453781595602 3400 1416193 SGTC_129 0088-0017 176.636 µM -0.562428592627834 0.271802712111794 no 2437 0.286912021341714 3455 182446 SGTC_2601 securinine 100 µM -0.56245327096067 0.271794023459135 no 2438 0.286903616422026 3355 442872 A GABA receptor antagonist. SGTC_2008 4012253 172 µM -0.562743102998846 0.271691990853197 no 2439 0.286804914474217 3402 603940 SGTC_1052 3253-3998 198 µM -0.563307378099863 0.271493397897084 no 2440 0.286612797457716 3420 5450317 SGTC_347 4534-1311 26.2 µM -0.563308944397173 0.271492846749567 no 2441 0.28661226427022 3447 2862016 SGTC_1302 1159-0335 255 µM -0.563889335227836 0.271288657634339 no 2442 0.286414724252616 3416 649284 SGTC_394 menadione 8.33 µM -0.565157827141545 0.27084265214874 no 2443 0.285983209375072 3457 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3031 9088762 49.47 µM -0.565692347487129 0.270654822883388 no 2444 0.285801469121692 3393 205253 SGTC_1278 0874-0585 172 µM -0.568569359466868 0.269644965941898 no 2445 0.284824211740304 3447 766306 SGTC_2445 5742597 35.57 µM -0.569128785051392 0.269448821986311 no 2446 0.284634372551352 3352 1774255 SGTC_409 arachidonic acid 100 µM -0.569467776734774 0.26933000064865 no 2447 0.284519366267217 3435 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2495 cafestol 54.53 µM -0.569980438333129 0.269150355499133 no 2448 0.284345482920151 3507 16667697 An anti-infammatory. SGTC_1247 0448-0043 5.84 µM -0.570068518304359 0.269119496865354 no 2449 0.284315613277179 3455 3089013 YGL099W LSG1 SGTC_854 0422-0053 192 µM -0.570518544673219 0.26896185877981 no 2450 0.284163023933668 3485 3596728 SGTC_26 0302-0163 425.158 µM -0.570788605557881 0.268867282403813 no 2451 0.284071473853603 3428 3100915 SGTC_1356 1502-0781 85.8 µM -0.572664428703067 0.268210823012009 no 2452 0.283435963351806 3415 567702 SGTC_168 3970-0862 530.542 µM -0.573421020057935 0.267946276212529 no 2453 0.283179830630013 3454 3135186 SGTC_823 0417-1665 178 µM -0.574210226863189 0.267670465309809 no 2454 0.282912774820323 3462 3429856 SGTC_1225 1216-0074 20.6 µM -0.574218120461342 0.267667707388956 no 2455 0.282910104355419 3408 4241466 SGTC_2732 terfenadine 20 µM -0.575551174579465 0.267202161096334 no 2456 0.282459295621455 3455 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2896 9052656 71.43 µM -0.575740710115247 0.267136002259728 no 2457 0.282395227054331 3446 6469436 SGTC_2743 auranofin 4.32 µM -0.575966075250167 0.267057347589401 no 2458 0.28231905613078 3408 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2324 6149169 200 µM -0.576431297482325 0.266895017404116 no 2459 0.28216184743302 3375 2888231 SGTC_402 epigallocatechin gallate 10 µM -0.576664496974107 0.266813665769572 no 2460 0.282083060118431 3403 65064 An antioxidant. SGTC_3170 9103054 49.47 µM -0.576728638472965 0.26679129220731 no 2461 0.282061391532395 3433 16432970 SGTC_2431 5490079 200 µM -0.576804796735224 0.26676472824046 no 2462 0.282035664427106 3431 5722345 SGTC_1401 3807-4679 7.6 µM -0.577064139117696 0.266674279764234 no 2463 0.281948064172576 3472 3291456 SGTC_2958 9077254 16.72 µM -0.577103405631466 0.266660586492009 no 2464 0.28193480193502 3536 16457351 SGTC_2330 7979373 200 µM -0.577284042367425 0.26659759826231 no 2465 0.281873795875276 3426 1863007 SGTC_72 0744-0168 198.391 µM -0.577438043109679 0.266543903974763 no 2466 0.281821790556291 3334 677577 SGTC_2983 9022671 12.99 µM -0.57887658928456 0.266042601132403 no 2467 0.281336223813743 3513 6405161 SGTC_2045 5106652 78.05 µM -0.579360164465568 0.265874192743203 no 2468 0.281173088629348 3468 673349 SGTC_2745 rifampicin 24.3 µM -0.579718395968096 0.265749470996229 no 2469 0.281052267883597 3415 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2941 9056145 11.23 µM -0.580667289836278 0.26541924785448 no 2470 0.280732355700164 3451 2119517 SGTC_3153 9100258 49.47 µM -0.581188435727989 0.265237973274863 no 2471 0.280556730374667 3404 25236848 SGTC_145 3737-0113 38.366 µM -0.581409358896296 0.265161146678471 no 2472 0.280482295673413 3527 6849351 SGTC_1575 cyproterone acetate 48 µM -0.581418945649112 0.265157813116535 no 2473 0.280479065866071 3417 9880 An androgen receptor antagonist and liver toxin. SGTC_1164 k060-0068 93.7 µM -0.58211547097076 0.264915670206907 no 2474 0.280244452464635 3511 5963676 SGTC_1955 wogonin 32.4 µM -0.582156598957572 0.264901375820057 no 2475 0.280230602133801 3577 5281703 A flavanone. SGTC_1013 4112-3890 241 µM -0.583684402187283 0.264370652520187 no 2476 0.279716331612695 3352 705171 SGTC_2810 7959871 45.46 µM -0.583987660993496 0.264265371884458 no 2477 0.279614306825526 3449 2974535 SGTC_2122 5258151 111.688 µM -0.58423739751734 0.264178688307867 no 2478 0.279530302003761 3423 2173356 SGTC_1730 st033808 45.1 µM -0.584628106163872 0.264043102349658 no 2479 0.279398902441515 3389 1045166 SGTC_3218 9131285 49.47 µM -0.584949524553622 0.263931588483721 no 2480 0.279290828444075 3554 17156417 SGTC_2886 9058944 51.95 µM -0.584985856278672 0.263918984955688 no 2481 0.279278613511373 3333 4949929 SGTC_2372 9071633 200 µM -0.586430113205471 0.263418218754725 no 2482 0.27879325650354 3522 21321366 SGTC_653 0203-0016 55.2 µM -0.587299025617379 0.263117175230983 no 2483 0.278501447712339 3462 295302 SGTC_1439 4092-1168 46 µM -0.58768429269832 0.262983751815133 no 2484 0.278372110240595 3484 2886240 SGTC_278 4092-0821 23.9 µM -0.588334497977753 0.262758655031161 no 2485 0.278153897151495 3488 877900 SGTC_2888 9058547 12.99 µM -0.588713281202026 0.262627568217934 no 2486 0.278026813524198 3431 16476514 SGTC_693 4161-2696 114 µM -0.590802192275873 0.261905253210045 no 2487 0.277326482968448 3481 805759 SGTC_2135 5326629 150.42 µM -0.591082068938568 0.261808553386171 no 2488 0.277232716793799 3452 5020077 SGTC_2491 paeonol 100 µM -0.593126450427668 0.261102757674822 no 2489 0.276548265012238 3485 11092 Increases levels of cortical cytochrome oxidase. SGTC_1053 3366-3204 134 µM -0.593968842724125 0.260812217647906 no 2490 0.276266476210798 3454 3632071 YPR165W RHO1 SGTC_1644 st010134 20.9 µM -0.594476523508406 0.2606371995512 no 2491 0.27609671988452 3502 3818134 SGTC_895 0964-0006 13.7 µM -0.596510926715816 0.259936465484789 no 2492 0.275416978262824 3516 6738897 SGTC_3321 9137793 26.8275 µM -0.596826773737491 0.259827761686631 no 2493 0.275311520281379 3511 4904192 SGTC_3007 9078383 71.4286 µM -0.599112089877571 0.259041933015776 no 2494 0.274549070035851 3473 6496995 SGTC_1429 4049-0205 9.46 µM -0.599693251025025 0.258842291174823 no 2495 0.274355343460845 3537 22774478 SGTC_1645 Cervolide 78 µM -0.600848820900287 0.258445563763465 no 2496 0.273970341790565 3478 23173 A fragrance. SGTC_1646 st011709 75.6 µM -0.601055392909248 0.258374677170709 no 2497 0.273901546257838 3513 5757843 SGTC_2006 4011487 200 µM -0.601189920183578 0.258328518636766 no 2498 0.273856748674087 3558 45595294 SGTC_2143 5623677 140.463 µM -0.602535029736773 0.257867224373053 no 2499 0.273409026478812 3520 5375313 SGTC_1931 st074438 57.1 µM -0.602550500123775 0.257861921418359 no 2500 0.273403879240836 3482 2787313 SGTC_1828 st055811 49 µM -0.602936883265643 0.257729494977919 no 2501 0.273275339135866 3514 5877589 SGTC_1180 1193-0155 285 µM -0.603183822284344 0.257644879202639 no 2502 0.273193204320346 3522 2921347 SGTC_1844 rapamycin 4 nM -0.603835285543026 0.257421718965681 no 2503 0.272976578710178 3500 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_850 0388-0143 75.9 µM -0.603916419073077 0.257393933522611 no 2504 0.272949606023199 3475 67273 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.604235912341935 0.257284533221294 no 2505 0.272843403946527 3503 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1794 st048918 76.9 µM -0.606388365399859 0.256548124568003 no 2506 0.272128446246853 3480 672303 SGTC_447 ml7 120 µM -0.606924784427436 0.256364773093506 no 2507 0.271950414661066 3552 4216 Selective myosin light chain kinase inhibitor. SGTC_3194 9111903 49.47 µM -0.608879803312258 0.255697113513529 no 2508 0.271302056086528 3564 17087251 SGTC_1495 4469-0029 237 µM -0.609812545880599 0.255378892302077 no 2509 0.270992994888749 3533 793680 SGTC_815 1582-0027 36.9 µM -0.612801162394965 0.254360670000106 no 2510 0.270003911094935 3543 3128206 SGTC_302 1094-0063 18.9 µM -0.61356316713512 0.25410139568216 no 2511 0.269752014656501 3495 5440289 SGTC_1362 1611-0397 101 µM -0.615694350089906 0.253376991209202 no 2512 0.269048133467738 3530 27816 SGTC_465 cgp-37157 41 µM -0.616576178804677 0.253077569071234 no 2513 0.26875715538396 3464 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1827 berberine 7.24 µM -0.617290477978655 0.252835167581064 no 2514 0.268521573165962 3434 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2168 5727979 200 µM -0.617734493603299 0.252684549975804 no 2515 0.268375185202829 3494 695210 SGTC_390 dec-rvkr-cmk 16.7 µM -0.617948034268624 0.252612130203779 no 2516 0.268304797059078 3548 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_884 0851-0618 334 µM -0.618840925435249 0.252309435278878 no 2517 0.268010579267876 3551 9642473 SGTC_3011 9081274 71.4286 µM -0.62008367362805 0.251888455435827 no 2518 0.267601350167169 3504 6625322 SGTC_3219 9131112 49.47 µM -0.620465505955782 0.25175918457155 no 2519 0.267475678491264 3503 17612988 YMR079W SEC14 SGTC_1613 st002381 52.1 µM -0.620909295928171 0.251608981727972 no 2520 0.267329652233642 3555 551167 SGTC_37 0566-0070 1.56 µM -0.62120354800471 0.25150941680733 no 2521 0.267232852646606 3552 1626686 SGTC_356 1634-0012 32.5 µM -0.622520023494938 0.251064221208757 no 2522 0.266799990744821 3557 735457 SGTC_558 k064-0027 21.3 µM -0.624091448258022 0.250533355158404 no 2523 0.266283764895131 3541 5088526 SGTC_2863 9028737 58.44 µM -0.625968811666829 0.249899916034757 no 2524 0.265667699157367 3504 6460917 SGTC_1469 k284-2957 126 µM -0.627164574934132 0.249496898462929 no 2525 0.265275680866957 3569 23884841 SGTC_3305 9127027 53.8275 µM -0.627583373861384 0.249355829047433 no 2526 0.265138451556162 3500 41905295 SGTC_2467 5474540 200 µM -0.630822159426565 0.248266300761857 no 2527 0.264078406327291 3559 5413519 SGTC_2386 9075165 157.42 µM -0.631539579712561 0.24802530425481 no 2528 0.263843889193449 3529 16452277 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.63201222547589 0.2478666008687 no 2529 0.263689444315008 3666 6728940 SGTC_5 0352-0601 109.883 µM -0.63240071805756 0.247736194750395 no 2530 0.263562532430057 3488 762456 SGTC_404 fumagillin 50 µM -0.632500791923385 0.247702608681287 no 2531 0.263529845573421 3528 12015870 A methionine aminopeptidase binder. SGTC_2499 avocadenofuran 51.48 µM -0.632732661641914 0.247624799583399 no 2532 0.263454118543744 3489 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2751 anetholtrithion 17.25 µM -0.634874209975014 0.246906772418802 no 2533 0.262755229271145 3545 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1620 st003704 16.5 µM -0.636016154543757 0.246524352526093 no 2534 0.262382946391348 3564 2834414 SGTC_2220 6782180 200 µM -0.636171621262153 0.246472313636305 no 2535 0.26233228391991 3517 833803 SGTC_663 1486-0733 13.9 µM -0.637013056696212 0.246190764746328 no 2536 0.262058169439811 3555 722445 YPR165W RHO1 SGTC_2355 9061122 103.12 µM -0.637035142695718 0.246183376973884 no 2537 0.262050976460056 3549 5302957 SGTC_2752 diclazuril 33.15 µM -0.638667243392229 0.245637768024697 no 2538 0.261519713261834 3614 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_247 mechlorethamine 29.705 µM -0.639562117583053 0.245338888733215 no 2539 0.261228658684916 3515 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_519 k048-0011 62.8 µM -0.640250686799714 0.245109046433772 no 2540 0.261004817411689 3566 6836379 SGTC_1176 0848-0131 83.3 µM -0.640654847412267 0.244974192812537 no 2541 0.260873478125737 3610 6769040 SGTC_3335 9143315 29.6265 µM -0.641620391854124 0.244652187592851 no 2542 0.260559844705961 3526 4899691 SGTC_553 k007-0256 45.7 µM -0.641733839094358 0.244614368359844 no 2543 0.260523006902299 3596 6287000 SGTC_88 0180-0332 8.668 µM -0.643578034252881 0.24400002180393 no 2544 0.25992454893647 3629 3101745 SGTC_3285 9112818 20.8695 µM -0.644596482791596 0.243661108746833 no 2545 0.25959435738302 3629 17017947 YPR165W RHO1 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.645328430245384 0.243417692833331 no 2546 0.259357186265481 3572 688667 SGTC_945 3381-0768 11.3 µM -0.645462314661511 0.243373182547752 no 2547 0.259313816145058 3612 1126236 YIL048W NEO1 SGTC_2854 9024559 71.43 µM -0.645787288692378 0.243265162228515 no 2548 0.259208560611551 3559 3163529 SGTC_1416 3966-0321 25.3 µM -0.645990072766354 0.243197770589938 no 2549 0.259142892259217 3583 582530 YLR208W SEC13 SGTC_1727 st034309 9.9045 µM -0.646089181187078 0.243164837361731 no 2550 0.259110800724594 3621 870305 SGTC_85 0868-0259 160.055 µM -0.648676697622427 0.242305872577739 no 2551 0.258273684634255 3519 83173 SGTC_2797 7859098 81.82 µM -0.650963465254089 0.241548116731362 no 2552 0.257535035623387 3605 972681 SGTC_2141 5621638 7.665 µM -0.651280269106354 0.241443240451482 no 2553 0.257432791385391 3608 2856238 SGTC_3205 9113483 49.47 µM -0.651422219294209 0.241396256600008 no 2554 0.257386985689356 3590 17018033 SGTC_863 0466-0191 129 µM -0.651848930236572 0.241255050181795 no 2555 0.257249316471563 3595 765160 YPR165W RHO1 SGTC_2759 disulfiram 3.38 µM -0.652132342970475 0.241161288563341 no 2556 0.257157900534568 3568 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_426 0988-0037 14.6 µM -0.65223825188798 0.241126255732357 no 2557 0.257123743515841 3620 5383008 SGTC_3052 9092717 49.47 µM -0.652726506614042 0.240964785330434 no 2558 0.256966305460295 3590 25237534 SGTC_2089 5281248 129.67 µM -0.653276110124079 0.240783096691867 no 2559 0.25678914546852 3612 2737878 SGTC_275 trichlorophene 5.69 µM -0.656733208925345 0.239641955514184 no 2560 0.255676238624099 3624 62616 SGTC_1155 4088-0394 48.2 µM -0.658177172172278 0.239166198312595 no 2561 0.255212145783112 3578 2326248 SGTC_2820 7989630 71.43 µM -0.658321504643721 0.239118672022569 no 2562 0.255165781247961 3512 2984098 SGTC_1041 0206-0046 107 µM -0.658787597553524 0.238965230609731 no 2563 0.255016086320703 3571 50494 SGTC_2962 9082311 13.18 µM -0.658962758442674 0.238907580202985 no 2564 0.254959841827701 3588 16459453 SGTC_929 2805-0021 398 µM -0.659483922748037 0.238736095267795 no 2565 0.254792533378264 3626 3098024 SGTC_2686 alizarin 95.37 µM -0.659706556154702 0.238662860064651 no 2566 0.254721079296656 3569 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2805 7950783 58.44 µM -0.659966614515382 0.238577329501791 no 2567 0.254637626982939 3600 1178958 YDL195W SEC31 SGTC_2316 5844804 197.44 µM -0.661118107851125 0.238198816679373 no 2568 0.25426828674916 3661 776813 SGTC_1710 st031758 61.5 µM -0.662554583338663 0.237727087628973 no 2569 0.253807932841313 3639 5394341 SGTC_203 k066-0004 30.888 µM -0.663472049442285 0.237426066219687 no 2570 0.25351413739826 3680 6795412 SGTC_804 1595-0054 20.9 µM -0.665739190093282 0.236683113707949 no 2571 0.252788909662598 3611 761523 Stimulates phospholipase C. SGTC_3287 9117173 37.0625 µM -0.665742810625673 0.236681928266326 no 2572 0.252787752377289 3584 2789709 SGTC_562 3772-2733 112 µM -0.6668961049782 0.236304480694744 no 2573 0.252419249541725 3630 2876874 YIL048W NEO1 SGTC_3226 9131256 49.47 µM -0.667219202957329 0.236198797381227 no 2574 0.25231606344465 3544 17178073 SGTC_2037 5169046 200 µM -0.671125772762117 0.234923045404316 no 2575 0.251070204873558 3637 5718022 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.672264273662324 0.234551967808961 no 2576 0.250707734765179 3646 5282362 SGTC_3080 9117754 49.47 µM -0.672350732811986 0.234523800974684 no 2577 0.250680219668579 3683 9550191 SGTC_3055 9094636 49.47 µM -0.672603007083482 0.234441625255201 no 2578 0.250599944064133 3665 25236176 SGTC_1482 3346-2049 8.48 µM -0.672642809924954 0.234428661348929 no 2579 0.250587279739181 3618 3826804 SGTC_1058 3448-5425 97.3 µM -0.672736081780313 0.234398283976418 no 2580 0.250557604163904 3571 7279705 SGTC_2334 9017922 200 µM -0.673248121175658 0.234231558529068 no 2581 0.250394725774903 3641 3163164 SGTC_1583 clindamycin 39.6 µM -0.673627614276433 0.234108033929739 no 2582 0.250274046235263 3559 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2575 plumbagin 510 nM -0.674096267955235 0.233955537453098 no 2583 0.250125056028866 3603 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2464 5717415 7.67 µM -0.674233724405543 0.233910820569926 no 2584 0.250081366022563 3563 5285744 SGTC_1738 st035555 74 µM -0.674243303258398 0.23390770458533 no 2585 0.250078321571771 3645 5331140 SGTC_284 0988-0104 32.6 µM -0.674490759476595 0.233827215468867 no 2586 0.249999679274407 3649 4666532 SGTC_3309 9129340 25.759 µM -0.674490759476595 0.233827215468867 no 2587 0.249999679274407 3654 17158987 SGTC_1200 1643-0193 18.4 µM -0.674863578311308 0.233705979132039 no 2588 0.249881221160807 3634 5403974 SGTC_2301 7769476 200 µM -0.675616757961385 0.2334611602363 no 2589 0.249641999495962 3631 977820 SGTC_174 3553-0389 74.3 µM -0.675915297467977 0.233364160205 no 2590 0.249547212343537 3623 738071 SGTC_227 fluconazole 33.516 µM -0.677184993571036 0.232951866500421 no 2591 0.249144293870003 3610 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_784 4579-0127 173 µM -0.677891480616674 0.232722632453895 no 2592 0.248920251028524 3699 1948547 SGTC_2144 5628481 200 µM -0.679082057205821 0.232336609542929 no 2593 0.24854293531078 3633 2818399 SGTC_1470 k295-0292 231 µM -0.680233928751184 0.23196347531622 no 2594 0.248178176160833 3678 5045612 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.681357139782741 0.231599946869159 no 2595 0.247822767951745 3664 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_678 1218-2179 85.9 µM -0.681748941848986 0.231473214453646 no 2596 0.247698857273554 3643 6820081 YOR116C RPO31 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.683939487965007 0.230765372591596 no 2597 0.247006688783348 3635 803109 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.684481803840982 0.230590318311332 no 2598 0.246835487838104 3511 6708630 An antioxidant. SGTC_492 tmb-8 126 µM -0.685299104587253 0.230326641833575 no 2599 0.246577598357731 3551 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3126 9127922 49.47 µM -0.685377924229194 0.230301222062502 no 2600 0.246552735394991 3678 45595682 SGTC_335 4077-0256 27.6 µM -0.685994340154975 0.230102478632277 no 2601 0.246358338744412 3676 3121989 SGTC_2118 5526350 200 µM -0.686523399685577 0.229931977005781 no 2602 0.246191556872556 3653 743594 SGTC_3101 9120531 49.47 µM -0.687154701629129 0.22972861797436 no 2603 0.245992623137165 3707 24824904 SGTC_3176 9106582 49.47 µM -0.687556464125186 0.229599252128205 no 2604 0.245866066020325 3555 17018027 SGTC_268 camptothecin 39.6153 µM -0.687915258461345 0.229483756355759 no 2605 0.245753073626963 3665 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3111 9122088 49.47 µM -0.688042020986477 0.229442959327291 no 2606 0.245713159927206 3567 16876704 SGTC_1186 1319-0216 26 µM -0.688847229647825 0.229183907321139 no 2607 0.245459705279631 3703 4565136 SGTC_664 1222-0054 14.9 µM -0.690234806340632 0.228737880783993 no 2608 0.245023269108778 3660 6813991 SGTC_1250 0485-0349 40.2 µM -0.694019005477341 0.227523957497218 no 2609 0.243835145094286 3665 6842794 YDL195W SEC31 SGTC_2649 anisomycin 9.56 µM -0.69461299060339 0.227333744549881 no 2610 0.243648934476766 3641 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3216 9129716 49.47 µM -0.696747636333935 0.226650903109888 no 2611 0.242980370698338 3644 8056934 SGTC_211 3455-0679 143.504 µM -0.697043174599878 0.226556456124815 no 2612 0.242887887389255 3689 748649 SGTC_716 1683-5115 658 µM -0.700115668157685 0.225575877589875 no 2613 0.241927535848101 3697 723597 SGTC_1233 0325-0408 14.2 µM -0.701653338220202 0.225086037294319 no 2614 0.241447689724537 3706 12874 SGTC_550 4123-0385 25.7 µM -0.701943306355398 0.22499373261224 no 2615 0.241357260087161 3693 5731123 SGTC_2360 9040895 200 µM -0.702832092488378 0.224710941692569 no 2616 0.241080197383877 3655 4914414 SGTC_1462 k081-0014 26.5 µM -0.703043993307306 0.224643549588833 no 2617 0.241014166745659 3474 3270634 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.703086186015714 0.224630132154424 no 2618 0.241001020205396 3684 16486 A toxic proline analog. SGTC_2128 5255449 168.493 µM -0.703571031887415 0.224475982036902 no 2619 0.240849978356128 3697 736008 SGTC_3114 9122766 49.47 µM -0.703912425280639 0.224367476698634 no 2620 0.240743656517007 3650 17176985 SGTC_827 3253-0474 693 µM -0.70423328753254 0.224265523934099 no 2621 0.240643752081884 3683 5402065 SGTC_637 1181-0519 7.26 µM -0.704421531266576 0.224205722445471 no 2622 0.240585150569959 3692 6252091 YGR060W ERG25 SGTC_1358 1509-0022 2.48 µM -0.706828134338524 0.223441988300538 no 2623 0.239836644239189 3701 3258434 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.708450653344245 0.222927919213572 no 2624 0.239332723083588 3709 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_979 1426-2828 121 µM -0.709003073046895 0.222753047764121 no 2625 0.239161284915542 3770 747872 SGTC_44 0929-0055 61.211 µM -0.714504702897117 0.22101574865195 no 2626 0.237457574566928 3646 1379590 SGTC_3081 9117243 49.47 µM -0.717541257205622 0.220060199440487 no 2627 0.23652009447157 3719 45595589 SGTC_2193 5925765 200 µM -0.717694821559728 0.220011938530501 no 2628 0.236472738479255 3689 877370 SGTC_1437 4092-1038 11.6 µM -0.719473996696887 0.219453237277687 no 2629 0.235924459218933 3707 3977136 SGTC_66 0109-0187 42.4 µM -0.719646515151499 0.21939910596339 no 2630 0.235871332382263 3702 759417 SGTC_1888 azatryptophan 97.5 µM -0.719899279044027 0.219319809802053 no 2631 0.23579350597678 3691 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_352 k048-0007 5.11 µM -0.72197230129244 0.218670090638854 no 2632 0.235155753641427 3720 6811911 SGTC_1597 7-benzyloxygramine 47.5 µM -0.723570281399971 0.218170014520266 no 2633 0.234664795965627 3687 260807 SGTC_1591 genipin 88.4 µM -0.724045500230141 0.218021425524444 no 2634 0.234518900857802 3720 442424 A DNA cross-linking agent. SGTC_2124 5246320 200 µM -0.724200598817522 0.217972942721435 no 2635 0.234471295499073 3729 579342 SGTC_2792 7535235 81.82 µM -0.724584171826985 0.217853067010196 no 2636 0.234353586051499 3712 1281891 SGTC_2921 7974240 10.71 µM -0.725122392804103 0.217684924245943 no 2637 0.234188473968433 3739 2979074 YDR527W RBA50 SGTC_2281 7943571 200 µM -0.725522636697577 0.217559934730787 no 2638 0.234065731404803 3800 1244024 SGTC_3234 9132280 49.47 µM -0.725672814494733 0.21751304738942 no 2639 0.234019685660525 3725 17612295 SGTC_2955 9076254 12.21 µM -0.727526781781185 0.216934696823492 no 2640 0.233451657573217 3659 16459619 SGTC_1633 st005664 67.9 µM -0.729444758923737 0.216337314690985 no 2641 0.232864823580183 3753 2063822 SGTC_2003 4023581 200 µM -0.732457618511886 0.215400840700831 no 2642 0.231944650846387 3762 16641307 SGTC_1561 5-methoxyflavone 52.9 µM -0.732888575952658 0.215267080605624 no 2643 0.231813195677901 3687 94525 SGTC_282 k297-0036 65.7 µM -0.73317106399874 0.215179428438052 no 2644 0.231727050727976 3732 5061378 SGTC_263 alizarin 107.927 µM -0.733455441489976 0.215091210929973 no 2645 0.231640347609478 3749 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_904 1141-0088 396 µM -0.733666140831277 0.215025862863605 no 2646 0.231576119693575 3698 1378119 SGTC_2682 pyrogallin 40.03 µM -0.736078773606543 0.214278410833899 no 2647 0.230841379866978 3765 822798 An ATP competetive kinase inhibitor. SGTC_969 1313-0238 134 µM -0.736950516634632 0.214008710355059 no 2648 0.230576220977568 3754 5212874 SGTC_1148 3909-7663 27.7 µM -0.737033772286996 0.213982963002666 no 2649 0.230550905935202 3788 4084526 SGTC_674 0498-0004 451 µM -0.738245616191926 0.213608396578191 no 2650 0.230182603790506 3733 4231473 SGTC_3351 9150312 21.596 µM -0.738499657342399 0.213529923965832 no 2651 0.230105437658681 3704 4904905 SGTC_3207 9114163 49.47 µM -0.738862554366167 0.213417855218032 no 2652 0.229995231179563 3749 849233 SGTC_3202 9113761 49.47 µM -0.739611660371366 0.213186627056409 no 2653 0.229767832174005 3795 4798415 SGTC_1068 loratadine 26.9 µM -0.741633527454053 0.212563262844897 no 2654 0.229154702080066 3777 3957 A H1 histamine antagonist. SGTC_644 1498-1197 63.3 µM -0.743471849739021 0.211997412675636 no 2655 0.228598029194161 3804 6741615 SGTC_2594 a-mangostin 100 µM -0.744299797061358 0.211742851937311 no 2656 0.228347562005913 3782 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3168 9103419 49.47 µM -0.744641779928535 0.211637758086749 no 2657 0.228244151793116 3680 16649256 SGTC_1202 1988-0068 29.6 µM -0.744837561532733 0.211577606705391 no 2658 0.228184962382498 3712 2850480 SGTC_491 tetrandrine 80.3 µM -0.745021323244097 0.211521157388469 no 2659 0.228129414721971 3711 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1968 st069590 43.6 µM -0.745460500215575 0.211386283400551 no 2660 0.227996690705137 3729 6384066 SGTC_116 0155-0182 31.788 µM -0.745886947070838 0.211255367124921 no 2661 0.227867855441154 3712 771486 SGTC_205 1486-1330 71.903 µM -0.746085650554634 0.211194382738013 no 2662 0.227807838470324 3729 4118834 SGTC_1262 0737-0114 49.6 µM -0.74617794947283 0.211166058646454 no 2663 0.227779963266103 3774 765919 SGTC_2537 larixol 68.93 µM -0.751149409960013 0.209643740862228 no 2664 0.226281371238454 3759 6708759 SGTC_2344 7990960 76.95 µM -0.751264589472862 0.209608548252277 no 2665 0.226246717785225 3747 140813 SGTC_571 k831-0106 44.2 µM -0.75484847345707 0.208515244862574 no 2666 0.225169952662722 3711 4783639 SGTC_3138 9097216 49.47 µM -0.757208067367456 0.207797263986073 no 2667 0.22446260887817 3767 25237486 SGTC_2412 st077135 33.4 µM -0.757864492121815 0.207597785957028 no 2668 0.22426605454016 3836 13258915 SGTC_2531 methyl deoxycholate 70.07 µM -0.758960965851445 0.207264835856625 no 2669 0.223937953660527 3748 16667744 Haematoxylin. SGTC_2993 9054257 71.4286 µM -0.759750633769273 0.207025244701669 no 2670 0.223701828184846 3748 6470217 YGL055W OLE1 SGTC_1974 st069448 26.9 µM -0.761461247400611 0.206506794054308 no 2671 0.22319080847998 3744 6323587 YNR016C ACC1 SGTC_1480 1070-0044 41.2 µM -0.76322913448309 0.205971794063726 no 2672 0.222663378197364 3776 3124987 SGTC_3244 9134489 49.47 µM -0.763454867768584 0.205903541636622 no 2673 0.222596084262599 3771 16584271 SGTC_2899 9053889 58.44 µM -0.76522035164387 0.205370195165501 no 2674 0.222070171418127 3706 6470052 SGTC_1726 st035556 14.5795 µM -0.766022127925512 0.205128252554691 no 2675 0.221831567929048 3916 5919439 SGTC_910 3454-3003 490 µM -0.766151030087619 0.205089371074524 no 2676 0.221793221138856 3698 820824 SGTC_2605 digitonin 300 nM -0.76628364097854 0.205049375481059 no 2677 0.221753774999852 3800 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_885 0865-0106 16.8 µM -0.767067368145213 0.204813097167079 no 2678 0.221520731122724 3715 2793380 SGTC_2352 9027995 87.8 µM -0.768895730017292 0.204262511913818 no 2679 0.220977606243921 3750 2997347 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.769527699557057 0.20407240840043 no 2680 0.220790053646561 3810 368090 SGTC_1296 1068-0102 11.9 µM -0.769590045257116 0.204053659829265 no 2681 0.220771555958717 3796 767053 SGTC_3354 9151612 71.43 µM -0.769816624351942 0.203985531706361 no 2682 0.220704338437723 3814 27261949 SGTC_2746 daunorubicin 9.88 µM -0.770499782206866 0.20378020088674 no 2683 0.220501742086346 3671 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_598 3937-0236 20.2 µM -0.771321979600451 0.203533243603181 no 2684 0.220258053733466 3858 1379313 SGTC_875 0709-0210 25.7 µM -0.772103310749545 0.203298726506015 no 2685 0.220026620755486 3774 6251364 SGTC_204 PMA1.184 62.41 µM -0.776574667047911 0.201959750672759 no 2686 0.218704876217867 3830 2252213 YGL008C PMA1 SGTC_3038 9091290 49.47 µM -0.777982349978682 0.201539306155844 no 2687 0.218289709232217 3801 25236843 SGTC_1990 st072050 59.8 µM -0.778620394468527 0.201348908884777 no 2688 0.218101680842358 3805 17233948 SGTC_848 0368-0089 85.6 µM -0.780867376611542 0.200679251456089 no 2689 0.217440250651812 3801 762535 SGTC_1448 4255-0083 152 µM -0.783898041926556 0.199778157491544 no 2690 0.216549969408274 3869 5399660 SGTC_2277 7947813 106.88 µM -0.786510581802507 0.199003339641749 no 2691 0.21578421108757 3908 1246798 SGTC_1030 k029-0042 36.7 µM -0.787191263318382 0.198801763270606 no 2692 0.215584955412828 3817 6080581 SGTC_3166 9102297 49.47 µM -0.788403899094895 0.198442959596675 no 2693 0.215230245422751 3813 25237072 SGTC_1381 2324-0066 62.1 µM -0.788709433537953 0.198352617459292 no 2694 0.215140926517285 3854 10885928 SGTC_1711 st032263 62.8 µM -0.78955609250032 0.19810240230386 no 2695 0.214893529558191 3821 3958979 SGTC_692 k241-0027 77.8 µM -0.789614708242577 0.198085086509684 no 2696 0.214876407934394 3841 3600480 SGTC_1972 st070201 17.4 µM -0.789798314555759 0.198030852915079 no 2697 0.214822781767229 3778 2829099 SGTC_1545 lovastatin 49.4 µM -0.790504286965239 0.197822406470816 no 2698 0.214616659798123 3902 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_656 4090-1979 187 µM -0.790785728252668 0.197739344676695 no 2699 0.21453451976129 3823 22330961 SGTC_2041 5107442 45.335 µM -0.791476365487233 0.197535606176771 no 2700 0.214333031324828 3820 793005 SGTC_766 1391-0721 126 µM -0.792092138459468 0.197354059753694 no 2701 0.214153476847975 3813 1020919 YIL115C NUP159 SGTC_2737 bleomycin 30.5 nM -0.792271040345782 0.197301333593359 no 2702 0.214101326900961 3844 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2249 haloperidol 116.36 µM -0.79338193639446 0.196974119858264 no 2703 0.213777665876577 3824 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_953 1188-0045 9.7 µM -0.793428755582821 0.196960336513421 no 2704 0.213764031305316 3847 6144426 SGTC_2338 7999974 200 µM -0.794062817420934 0.196773729244671 no 2705 0.213579431224485 3873 315925 SGTC_1374 2889-5571 141 µM -0.795500061791108 0.196351138312977 no 2706 0.213161337514428 3851 2853281 SGTC_2024 5144227 134 µM -0.795679963210036 0.196298280919906 no 2707 0.213109037912457 3885 3475211 SGTC_1483 3453-0561 55.9 µM -0.797043092680657 0.19589805600009 no 2708 0.212713002349166 3837 4546991 SGTC_2481 5478948 45.16 µM -0.79806698227997 0.195597760299649 no 2709 0.212415810342024 3867 77792 SGTC_3264 9137442 49.47 µM -0.799087457282877 0.195298744334863 no 2710 0.212119850981284 3799 17015726 SGTC_2821 7996764 71.43 µM -0.799694462184811 0.195121013719988 no 2711 0.211943921124482 3857 2987135 SGTC_2309 7664088 163.95 µM -0.799913999178272 0.195056757655827 no 2712 0.211880313152011 3820 704922 SGTC_181 1447-1644 8.07 µM -0.801639265249747 0.194552239135944 no 2713 0.211380828746773 3830 534600 SGTC_2748 diazoxide 86.69 µM -0.80410538920793 0.193832452425445 no 2714 0.210668056215398 3833 3019 A potassium channel activatior. SGTC_273 hydroxyurea 18.1 mM -0.805591531422953 0.193399477522971 no 2715 0.210239205088012 3902 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2113 5491891 107.031 µM -0.80612623783403 0.193243839816928 no 2716 0.210085032138109 3856 789979 SGTC_2453 5731132 22.18 µM -0.807596740994733 0.19281621285977 no 2717 0.20966138172778 3869 1362040 SGTC_2674 ligustilide 100 µM -0.807885152280625 0.192732409808761 no 2718 0.209578349710434 3882 5319022 A signalling regulator. SGTC_1572 epiandrosterone 68.9 µM -0.812366258963876 0.191433205043197 no 2719 0.20829075051806 3769 441302 A steroid. SGTC_408 cantharidin 100 µM -0.813259593310012 0.191174844129205 no 2720 0.208034619283626 3826 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_675 1309-0189 238 µM -0.813556277899721 0.191089087393751 no 2721 0.207949596877972 3884 4246530 SGTC_105 0111-0055 734.78 µM -0.815026813261955 0.190664377205136 no 2722 0.207528481066998 3869 5179370 SGTC_737 1950-0117 57.9 µM -0.816355300241663 0.190281191037856 no 2723 0.20714847718952 3790 5393513 SGTC_735 3076-0345 636 µM -0.818204117464656 0.189748709781014 no 2724 0.20662032222559 3911 2888990 SGTC_3148 9097893 49.47 µM -0.819472124208887 0.189384039159391 no 2725 0.206258549941495 3869 17174100 SGTC_907 3448-6986 75.5 µM -0.822181380229343 0.188606321190318 no 2726 0.205486837162067 3876 590582 SGTC_2243 6634756 200 µM -0.824882629814254 0.187832864952262 no 2727 0.204719114430414 3901 885676 SGTC_639 0833-0042 114 µM -0.825051809475253 0.187784488543896 no 2728 0.204671088684383 3851 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_3270 9137563 49.47 µM -0.825358014043882 0.187696949851089 no 2729 0.20458418214373 3850 17015724 SGTC_3240 9133527 49.47 µM -0.825624868714678 0.187620681187533 no 2730 0.204508461743497 3812 17617455 SGTC_564 3555-0129 330 µM -0.827198807383246 0.18717122970505 no 2731 0.204062193758889 3753 563260 SGTC_1948 st076329 66.6 µM -0.827945277737209 0.186958301769519 no 2732 0.203850745650183 3747 24208413 SGTC_106 0092-0003 11.579 µM -0.827995726053492 0.18694391698064 no 2733 0.203836460175523 3803 1072148 SGTC_3117 9124945 49.47 µM -0.82831110668503 0.18685400514578 no 2734 0.203747167212038 3783 17592065 SGTC_351 caspofungin 25 nM -0.828521680663928 0.186793987531653 no 2735 0.203687560890135 3880 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2902 5787006 60.46 µM -0.828974109371576 0.186665077054559 no 2736 0.2035595289038 3828 591003 SGTC_233 rapamycin 362 pM -0.82975771771237 0.186441933938454 no 2737 0.203337890580334 3880 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1909 st060837 51.5 µM -0.832225755710864 0.185740206947851 no 2738 0.202640764324334 3898 678937 SGTC_3150 9097574 49.47 µM -0.832250171271137 0.18573327316741 no 2739 0.202633875006321 3870 17217476 SGTC_1355 1499-0035 1.68 µM -0.832612965129354 0.18563026217847 no 2740 0.202531522264901 3859 1548538 SGTC_1135 dihydrocapsaicin 536.708 nM -0.833388347331769 0.185410220524187 no 2741 0.20231287221968 3805 107982 A Capsaicinoid. SGTC_891 0929-0073 133 µM -0.835713861150364 0.184751246733598 no 2742 0.201657947749387 3951 5603632 SGTC_3179 9107801 49.47 µM -0.836348119532504 0.184571771867208 no 2743 0.201479544940025 3872 4818259 SGTC_2513 baicalein 25.65 µM -0.836649789873229 0.184486446856844 no 2744 0.20139472496673 3898 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1097 itavastatin 7.23 µM -0.836664934851354 0.184482163869432 no 2745 0.201390467251456 3875 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1498 4478-3555 97.6 µM -0.83999718989016 0.183541309093502 no 2746 0.200454981058281 3833 3437919 SGTC_1590 st077108 57.8 µM -0.840045329405005 0.183527738959399 no 2747 0.200441485684245 3877 5489485 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.840075273383208 0.183519298313191 no 2748 0.200433091500502 3835 5355888 SGTC_1611 st001856 99.4 µM -0.842146312597691 0.182936098346356 no 2749 0.199853030351245 3879 647478 SGTC_3336 9143619 71.43 µM -0.842768874390156 0.182761012687252 no 2750 0.199678859459777 3880 45595730 SGTC_631 k072-0230 41.5 µM -0.84362979580882 0.182519064575263 no 2751 0.199438154456423 3911 5773147 SGTC_603 3794-0023 45.9 µM -0.843705525463836 0.18249779155148 no 2752 0.199416989565219 3873 3802260 SGTC_2710 st078562 53.7235 µM -0.844553077352861 0.182259813586906 no 2753 0.199180208394853 3857 17250908 SGTC_2104 5389443 200 µM -0.84495925192481 0.182145835537804 no 2754 0.199066795168008 3948 2244536 SGTC_1475 4092-1048 11.7 µM -0.845975470516079 0.181860866168494 no 2755 0.198783214201381 3922 2881759 SGTC_1212 0520-0165 585 µM -0.846353733801015 0.181754864330545 no 2756 0.19867772013882 3999 5403258 SGTC_2702 st077768 96.8 µM -0.850616388480413 0.180563001401381 no 2757 0.197491241331011 3890 6484119 SGTC_1221 2958-7315 257 µM -0.851106653517641 0.18042623546245 no 2758 0.197355054876308 3922 4562705 SGTC_3149 9097855 49.47 µM -0.853440324087619 0.179776118371764 no 2759 0.196707583870587 3931 25236625 YMR079W SEC14 SGTC_3003 9075612 71.4286 µM -0.854947120983396 0.179357135715905 no 2760 0.196290211249276 3942 6501993 SGTC_1787 fluconazole 80 µM -0.856474268142388 0.178933121437514 no 2761 0.195867750003647 3746 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2252 omeprazole 400 µM -0.85669798152904 0.178871060158649 no 2762 0.195805909578432 3859 4594 A proton pump inhibitor. SGTC_1 0258-0098 57.368 µM -0.856828619933855 0.178834825471512 no 2763 0.195769803073977 3857 6790032 YDR047W HEM12 SGTC_2646 retinol 96.75 µM -0.857325262357323 0.178697115788898 no 2764 0.195632575411048 3905 445354 A vitamin A analog and teratogen. SGTC_46 0329-0187a 2.197 µM -0.858460143818832 0.178382685008808 no 2765 0.195319214689215 3982 46494817 SGTC_1094 duloxetine 25.4 µM -0.859509150239728 0.178092357021546 no 2766 0.19502983695537 3913 60834 A selective serotonin reuptake inhibitor. SGTC_458 nppb 133 µM -0.8596354787202 0.178057413861 no 2767 0.194995005715301 3915 4549 A chloride channel blocker. SGTC_2665 lovastatin 100 µM -0.859985925620696 0.177960500928604 no 2768 0.194898400431038 3942 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.862009986951749 0.177401416047062 no 2769 0.194341011077791 3937 1377 SGTC_1215 3852-0577 11.2 µM -0.862061408689916 0.177387226827476 no 2770 0.194326863128329 3984 2884876 SGTC_788 1182-0090 188 µM -0.864101399678182 0.176824893620305 no 2771 0.193766095092441 4002 5715185 SGTC_2625 euphol 100 µM -0.864528645764502 0.176707264068595 no 2772 0.193648775543735 3957 6708538 A triterpene alcohol. SGTC_1441 4106-0040 13 µM -0.869787633497041 0.175263412034537 no 2773 0.192208235428418 3906 2904180 SGTC_1683 st010134 710 nM -0.871690870691586 0.17474272825163 no 2774 0.191688520986963 3931 3818134 SGTC_763 3453-1109 128 µM -0.871946713386822 0.174672810273904 no 2775 0.191618724041541 3972 1560353 SGTC_329 k048-0121 21.3 µM -0.873528607692391 0.174240896762389 no 2776 0.191187510136951 3951 6832902 SGTC_3277 9138724 49.47 µM -0.8745463663742 0.173963371481878 no 2777 0.190910390640033 3881 15943418 SGTC_149 3970-0822 46.1 µM -0.875083590486002 0.173816993107839 no 2778 0.190764212474648 3949 3114250 YBL034C STU1 SGTC_1263 0774-1208 64.8 µM -0.875710004589586 0.173646411940459 no 2779 0.190593852559645 3946 906585 SGTC_1199 1638-0010 4.46 µM -0.875985464127151 0.173571434251966 no 2780 0.190518968010119 3922 3111136 SGTC_2310 7668677 200 µM -0.877795492527817 0.173079272826773 no 2781 0.190027355514873 3938 2197143 SGTC_852 0418-0143 439 µM -0.878347962042422 0.172929229122469 no 2782 0.189877457563343 3969 5369229 SGTC_2258 7960471 200 µM -0.879001643557682 0.172751804606028 no 2783 0.189700192346503 3980 2974708 SGTC_3338 9144300 39.5675 µM -0.879103434047756 0.172724186720979 no 2784 0.1896725979848 3966 4901274 SGTC_1676 st018489 23.4 µM -0.879107387267683 0.172723114186661 no 2785 0.189671526357083 3988 3696235 SGTC_3010 9080089 71.4286 µM -0.881953406732591 0.171952072400442 no 2786 0.188901002113529 3953 17027233 SGTC_303 1348-1668 34.2 µM -0.88218984242544 0.171888116407721 no 2787 0.18883707698384 3949 5380509 SGTC_1799 st045822 46.1415 µM -0.882784195840084 0.171727410557575 no 2788 0.188676440505969 3879 3674992 SGTC_951 1171-0579 82.7 µM -0.883812023762183 0.171449725105577 no 2789 0.18839884730871 3903 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_212 3807-4682 38.772 µM -0.884236654077689 0.171335087714588 no 2790 0.188284237786259 4019 3125501 YBL034C STU1 SGTC_714 4296-0578 26.1 µM -0.885953856562903 0.170871994676205 no 2791 0.187821196408787 3982 1589775 SGTC_727 3032-0951 202 µM -0.886584965892473 0.170701999347425 no 2792 0.187651195490264 3957 3652836 SGTC_2439 5492030 7.2 µM -0.886906673426167 0.170615386019234 no 2793 0.187564574233564 3940 5722370 SGTC_1478 0453-0656 35.7 µM -0.888916595358913 0.170074891827604 no 2794 0.187023952921093 3953 5258496 SGTC_508 roscovitine 141 µM -0.888989959262227 0.170055184099306 no 2795 0.187004238024222 4015 160355 A CDKinase inhibitor. SGTC_2780 5215298 71.43 µM -0.889375208844918 0.169951718618309 no 2796 0.186900731978622 3989 2834131 SGTC_1192 1488-0095 21.4 µM -0.892958578033286 0.168991276467845 no 2797 0.185939677697292 4007 915875 SGTC_1275 0867-0008 21.1 µM -0.893648100411304 0.168806866121269 no 2798 0.185755100980359 3919 3422836 SGTC_1630 st005209 31.3 µM -0.895412801869289 0.168335492086723 no 2799 0.18528322986562 3893 3367314 SGTC_2012 4023501 200 µM -0.895597470185361 0.16828621382556 no 2800 0.185233893666582 3990 3477460 SGTC_941 3237-0776 460 µM -0.896248857403194 0.168112466935046 no 2801 0.185059933459933 4007 760008 SGTC_2023 5144124 124 µM -0.897227738412135 0.167851583574722 no 2802 0.184798703324654 3963 2830192 SGTC_2370 9071495 200 µM -0.897746734625127 0.167713370734324 no 2803 0.184660293866356 3978 21791103 SGTC_921 1561-0023 372 µM -0.899015567126939 0.167375779203943 no 2804 0.184322184445152 3930 24050882 SGTC_946 3434-1334 87.4 µM -0.900773051102057 0.166908898643263 no 2805 0.183854499411573 3951 4047976 SGTC_613 3914-0030 117 µM -0.901547223587954 0.166703504317555 no 2806 0.183648718644559 3703 1145395 SGTC_3224 9130643 49.47 µM -0.901912607677739 0.166606621592342 no 2807 0.183551646724618 3996 17644395 SGTC_1526 st051518 75 µM -0.903566582805599 0.166168519628191 no 2808 0.183112633781777 3984 673993 SGTC_1539 benzyladenosine 56 µM -0.904663172456221 0.165878467561722 no 2809 0.182821928514438 3964 92208 A nucleotide analog. SGTC_1684 st024538 14.6195 µM -0.904999819281974 0.165789488907917 no 2810 0.182732741465836 3960 6732859 SGTC_1399 3562-5772 25 µM -0.906229790577809 0.165464659268027 no 2811 0.182407119049051 3903 23847490 SGTC_97 0535-0701 19.132 µM -0.906584535491318 0.165371049349773 no 2812 0.182313271328834 3895 2832013 YGL099W LSG1 SGTC_1057 3448-5381 134 µM -0.906998993873756 0.165261725680623 no 2813 0.182203664642587 3996 5497911 SGTC_2891 9063876 19.48 µM -0.908110046666287 0.164968888776167 no 2814 0.181910041487235 3972 6472478 SGTC_279 1273-0055 2.93 µM -0.911412231545985 0.164100526325537 no 2815 0.181039105625611 3985 2847562 SGTC_2799 7812892 81.82 µM -0.911515744559258 0.164073353932946 no 2816 0.181011846850195 4017 20205235 SGTC_188 3229-0966 278.469 µM -0.912993958849743 0.163685637914539 no 2817 0.180622859403619 4018 5722370 SGTC_1072 oxiconazole 14.9 nM -0.913139036733028 0.1636476179864 no 2818 0.180584710883103 3987 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_514 4466-0038 2.65 nM -0.914148101508785 0.163383335418621 no 2819 0.180319515091252 3842 5722064 SGTC_1635 st007035 42.4 µM -0.914343787925788 0.163332115610906 no 2820 0.180268114374982 3964 3716403 SGTC_1700 st030840 7.9285 µM -0.914392312373569 0.163319416226666 no 2821 0.180255369939417 4026 5499307 SGTC_572 0960-0087 17.7 µM -0.915976079134486 0.162905279124099 no 2822 0.179839720709034 3975 6796365 SGTC_851 0394-0702 453 µM -0.916481735496303 0.162773199630712 no 2823 0.179707141393847 3985 762646 SGTC_253 dyclonine 31.25 µM -0.917545707984495 0.16249551321431 no 2824 0.179428376378242 4083 3180 An oral anasthetic. SGTC_2629 bisabolol 100 µM -0.918550096533571 0.16223366064712 no 2825 0.179165472177201 4029 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2171 5739187 198.077 µM -0.920046539236927 0.161844035276961 no 2826 0.178774219809616 3929 2262761 SGTC_1999 st074831 12.5 µM -0.920186966394233 0.161807503896198 no 2827 0.178737532058281 3957 17112523 SGTC_196 k015-0023 18.111 µM -0.920995729923097 0.161597212944569 no 2828 0.178526328199739 3931 5211998 SGTC_432 NS 1619 61.3 µM -0.923194381440702 0.16102643068412 no 2829 0.177952958163577 4039 4552 A K+/calcium channel activator. SGTC_893 0958-0369 48.9 µM -0.925591386533681 0.160405655716135 no 2830 0.177329185681926 3966 6819948 SGTC_1340 1486-1359 257 µM -0.925689694043832 0.160380229521209 no 2831 0.177303632631848 3932 4309068 SGTC_589 1227-0070 34.1 µM -0.926257532341421 0.160233415711384 no 2832 0.177156080051445 4053 2841384 SGTC_2106 5357045 167.29 µM -0.927674243558362 0.159867510092861 no 2833 0.176788286420158 4037 668842 SGTC_31 0508-1974 57.237 µM -0.930773070034025 0.159069057561101 no 2834 0.175985481398123 3947 6810525 SGTC_214 4373-3496 70 µM -0.930804138419214 0.159061065642705 no 2835 0.175977444296668 4075 3779166 SGTC_473 2-arachidonoylglycerol 10 µM -0.932701364390068 0.158573528669521 no 2836 0.175487090122172 3853 5282280 An endocannabinoid. SGTC_3214 9129694 49.47 µM -0.935120771597343 0.157953228078682 no 2837 0.174863031488835 4049 17158655 SGTC_2641 levomentholum 100 µM -0.936168896050637 0.157684999572729 no 2838 0.174593117474046 3988 16666 SGTC_2203 7227154 166.4 µM -0.937274126826076 0.157402481139005 no 2839 0.174308784127793 3997 896304 SGTC_959 1222-0044 107 µM -0.937421927345388 0.157364725694737 no 2840 0.174270783057427 4002 6083612 SGTC_464 bw-b 70c 158 µM -0.937657612017351 0.157304532677669 no 2841 0.174210196936908 4058 5353454 SGTC_3039 9090270 49.47 µM -0.938965139207962 0.15697086989509 no 2842 0.173874321512315 4025 17173750 SGTC_1854 st056233 32.9 µM -0.939059113232491 0.156946906975719 no 2843 0.173850197493164 3904 5393174 SGTC_1998 st075797 76.8 µM -0.939250663717537 0.156898069985919 no 2844 0.173801031267491 3960 24208315 SGTC_35 0133-0054 64.071 µM -0.943128948375905 0.155911427882486 no 2845 0.172807475188538 4040 99677 SGTC_1406 3909-7906 11.9 µM -0.94434878492005 0.155601946783942 no 2846 0.172495721915213 4019 X1406 SGTC_750 4073-0104 132 µM -0.944374449931755 0.155595439745577 no 2847 0.172489166570611 3807 22330957 SGTC_3343 9148379 18.9835 µM -0.945710642740717 0.155256912927558 no 2848 0.172148096339157 4066 1955036 SGTC_2502 avocadyne acetate 18.59 µM -0.945835566760222 0.155225288074337 no 2849 0.172116230843218 3962 3952079 SGTC_624 k048-0052 28 µM -0.946576048115083 0.155037920524178 no 2850 0.171927426887826 4004 6835531 SGTC_2570 licareol 100 µM -0.94747678829954 0.154810203318874 no 2851 0.171697939333754 4036 443158 SGTC_1268 0828-0275 2.46 µM -0.947602988100865 0.154778316252198 no 2852 0.171665802208151 4088 745337 SGTC_407 eburnamonine 100 µM -0.947948243131862 0.15469110239323 no 2853 0.171577901705621 3883 3195 SGTC_1788 fluconazole 20 µM -0.948001840676153 0.154677566187398 no 2854 0.1715642585718 4078 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2312 7706453 155.7 µM -0.948491719825357 0.154553882144041 no 2855 0.171439593063865 4040 976098 SGTC_1103 duloxetine 36.1 µM -0.948790364155746 0.154478512897181 no 2856 0.171363621820795 4119 60835 A selective serotonin reuptake inhibitor. SGTC_1565 sinapyl alcohol 95.1 µM -0.949408232958756 0.154322657711591 no 2857 0.171206512343805 4078 5280507 A phenol propionate derived from cinnamic acid. SGTC_3235 9132602 49.47 µM -0.951560750023946 0.15378050536076 no 2858 0.170659897610155 4042 4912240 SGTC_317 4495-0002 170 µM -0.952014448178576 0.153666393922957 no 2859 0.170544827250039 4068 15991618 SGTC_2061 5245884 80.95 µM -0.954464472394873 0.153051147542007 no 2860 0.169924292319451 3999 573863 SGTC_1050 3232-1156 69.3 µM -0.954622623438402 0.153011489072053 no 2861 0.169884286084235 4004 700529 SGTC_2507 purpurin 79.67 µM -0.955018277303301 0.152912303464695 no 2862 0.169784227068378 4034 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2373 9071805 200 µM -0.955032158592442 0.152908824368739 no 2863 0.169780717241508 4025 10149009 SGTC_3325 9138760 55.175 µM -0.955352040543505 0.152828666240077 no 2864 0.169699849296341 3971 43844959 SGTC_1332 1480-0653 17.5 µM -0.955705002972276 0.152740250930907 no 2865 0.169610647096107 4039 5749438 SGTC_3254 9136651 49.47 µM -0.956284283100229 0.152595217724283 no 2866 0.169464314108648 4023 16454030 SGTC_3105 9121040 49.47 µM -0.958257247204321 0.152101936384518 no 2867 0.168966528187885 3870 41448907 SGTC_2639 lactacystin 53 µM -0.962410075875462 0.151067108266211 no 2868 0.1679218271569 4101 3870 A proteasome inhibitor. SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.964989896878761 0.150426616743074 no 2869 0.167274936091142 4054 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1304 1165-0502 251 µM -0.965157183384507 0.150385147116944 no 2870 0.167233044465421 4060 767425 SGTC_3265 9137266 49.47 µM -0.965352951204598 0.150336626765721 no 2871 0.167184029181811 3931 17224265 SGTC_232 clozapine 119 µM -0.96847311074854 0.14956471450857 no 2872 0.166404070886242 3998 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2139 5578692 56.4705 µM -0.969744781710859 0.14925086931602 no 2873 0.166086861391948 4010 650991 YMR113W FOL3 SGTC_2699 st077704 54.6 µM -0.970093429385497 0.149164900812289 no 2874 0.165999961932239 4065 645852 SGTC_890 0929-0006 47.2 µM -0.972736826519051 0.148514175848128 no 2875 0.165342058647445 4033 1378169 SGTC_1251 0490-5699 265 µM -0.974943250787707 0.147972476061687 no 2876 0.16479420523695 4120 3883818 SGTC_942 3253-1115 227 µM -0.975753629518252 0.14777385226632 no 2877 0.164593284420472 4124 46497897 SGTC_2380 9035439 200 µM -0.975875169810693 0.147744078148347 no 2878 0.164563164088386 4171 6462575 SGTC_2862 9027634 71.43 µM -0.978225488168849 0.147169103039788 no 2879 0.163981406495918 4006 5012562 SGTC_2603 homopterocarpin 100 µM -0.982477013343289 0.146132837861329 no 2880 0.16293245096861 4083 101795 A weak amylase inhibitor. SGTC_924 2046-0044 21.3 µM -0.984897326903733 0.145545106058972 no 2881 0.1623372532707 4058 3623589 SGTC_2398 5228213 48.84 µM -0.985555186132945 0.145385631310359 no 2882 0.162175719044189 4095 80771 YMR134W ERG29 SGTC_3174 9107204 49.47 µM -0.986368761878458 0.145188571211834 no 2883 0.161976094166884 4116 3938802 SGTC_2879 9041815 71.43 µM -0.987764472545003 0.144850928244442 no 2884 0.161634005414182 4081 4942971 SGTC_1008 4106-0037 6 µM -0.987837022870281 0.14483339171979 no 2885 0.161616236211524 4014 2905394 SGTC_3181 9108277 49.47 µM -0.988876846764843 0.144582207440689 no 2886 0.161361699927391 4001 17097298 SGTC_2661 dactinomycin 12.96 µM -0.988922601134571 0.144571161565709 no 2887 0.161350505820883 4046 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1443 4112-3303 14 µM -0.989376412133611 0.144461634736418 no 2888 0.161239505409988 4112 704433 SGTC_147 4466-0538 29.23 µM -0.98985177054054 0.144346967435534 no 2889 0.161123288018461 4168 6742687 YHR072W ERG7 SGTC_529 4076-0302 30.3 µM -0.99074481583407 0.144131710441401 no 2890 0.160905100818082 4033 5816522 SGTC_3100 9120536 49.47 µM -0.991299172450883 0.143998198895175 no 2891 0.160769758485932 3905 16421196 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.992297568473252 0.14375795510303 no 2892 0.160526194550664 4066 689007 SGTC_617 3770-0098 35 µM -0.992937515931594 0.143604107012842 no 2893 0.160370202858473 4006 5962639 SGTC_391 gliotoxin 8.33 µM -0.993482351480091 0.143473212137197 no 2894 0.160237473456549 4180 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_438 sphingosine 6.67 µM -0.998936351553014 0.142167346440213 no 2895 0.158912762593332 4032 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_793 0488-0545 106 µM -1.00060552290773 0.141769304956177 no 2896 0.158508779475007 4105 292548 SGTC_3086 9117350 49.47 µM -1.00242866715985 0.141335409287713 no 2897 0.158068301201457 4031 2679265 SGTC_2664 lyso-paf C-16 73.48 µM -1.0039767052994 0.140967694305064 no 2898 0.157694920948828 4054 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2228 7354201 200 µM -1.00473959745067 0.140786718762993 no 2899 0.157511127881268 4125 753451 SGTC_3068 9116768 49.47 µM -1.0050735585447 0.140707545151954 no 2900 0.157430715564922 4079 41904888 SGTC_3069 9117009 49.47 µM -1.00754985840481 0.140121420677633 no 2901 0.15683530536725 4068 41904981 SGTC_1354 1498-1681 81 µM -1.00848389904713 0.139900770608605 no 2902 0.156611106736125 4112 5754243 SGTC_2342 7990637 118.86 µM -1.00860293630412 0.139872667202168 no 2903 0.15658254927943 4158 2033102 YER133W GLC7 SGTC_3197 9113331 49.47 µM -1.00876681854467 0.139833982659159 no 2904 0.156543238962555 4134 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1508 1080-0625 72.9 µM -1.00942099120223 0.139679637101784 no 2905 0.156386387770952 3964 767111 SGTC_3144 9087057 49.47 µM -1.01121676824505 0.139256536902671 no 2906 0.15595634595498 3950 17249618 SGTC_1463 k081-0032 34.1 µM -1.01276124140495 0.138893344261369 no 2907 0.155587108948958 3781 977755 SGTC_1574 spiramycin 23.7 µM -1.01408422614608 0.138582749339927 no 2908 0.15527128204835 4071 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1316 1272-0050 65.9 µM -1.01439191500836 0.138510581617212 no 2909 0.155197890328552 4063 7340392 SGTC_2567 aureobasidin a 60 nM -1.01498063280941 0.138372570581379 no 2910 0.155057529801814 4260 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2268 7933382 153.85 µM -1.01564321163318 0.138217356704904 no 2911 0.154899659811575 4118 935025 YOR257W CDC31 SGTC_3076 9116187 49.47 µM -1.0172806875747 0.137834275458476 no 2912 0.154509960557514 4093 27241210 SGTC_1721 st082152 9.2685 µM -1.01861052436502 0.137523698732066 no 2913 0.154193952933237 4039 5296051 SGTC_2907 7721985 69.9 µM -1.02103821892729 0.136957955743602 no 2914 0.153618165848208 4143 3267881 SGTC_3142 9086498 49.47 µM -1.02131081662441 0.136894529820359 no 2915 0.153553601663521 4018 25236367 SGTC_1028 k015-0029 4.8 µM -1.02417487879599 0.136229355453344 no 2916 0.152876340982471 4060 4588309 SGTC_876 0720-0963 56.8 µM -1.02663676665152 0.13565935594605 no 2917 0.152295767321885 4137 765861 SGTC_209 4077-0173 175.592 µM -1.02898993595515 0.1351160571332 no 2918 0.15174220204739 4095 15993494 SGTC_1388 3346-4487 254 µM -1.02899627726136 0.135114595073505 no 2919 0.151740712111883 4176 3345614 SGTC_713 1488-1073 324 µM -1.03240456514915 0.134330345338529 no 2920 0.150941317124061 4053 3312542 SGTC_1722 st034304 3.6505 µM -1.03444419294691 0.133862523307035 no 2921 0.150464276752795 4114 4036148 YLR033W RSC58 SGTC_2156 5649887 115 µM -1.03832757929516 0.132974903711753 no 2922 0.149558786526983 4172 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2066 5222451 176 µM -1.03861566536927 0.132909218144198 no 2923 0.149491758615912 4093 2281147 SGTC_2581 avocatin a 64 µM -1.03974819172293 0.132651211054643 no 2924 0.149228452298827 4107 6710728 A skin care supplement. SGTC_3199 9111318 49.47 µM -1.04019856603597 0.132548704735273 no 2925 0.149123828798297 4081 8548020 SGTC_96 0929-0093 37.281 µM -1.04141096571459 0.132273030788494 no 2926 0.148842427693241 4133 6991579 SGTC_1963 st076565 50.3 µM -1.04143170288157 0.132268319037284 no 2927 0.148837617631762 4148 4914280 SGTC_2523 spermine 47.74 µM -1.04827604941505 0.130719512807501 no 2928 0.147255720532532 4166 1103 A DNA binding polyamine. SGTC_575 k072-0246 11.9 µM -1.0491481974162 0.130523058832158 no 2929 0.147054958147114 4218 6796779 SGTC_2782 7736369 71.43 µM -1.0497845861561 0.130379839249505 no 2930 0.146908581771809 4171 2950836 YOL077C BRX1 SGTC_3251 9135047 49.47 µM -1.05216911013697 0.129844167942664 no 2931 0.146360984496032 4166 17682963 SGTC_1811 st050069 61.5 µM -1.05589188664333 0.129010915101491 no 2932 0.145508805642606 4098 3877702 SGTC_704 1310-0270 142 µM -1.05594973134835 0.128997997295912 no 2933 0.145495590821518 4166 5718033 SGTC_554 4483-2211 187 µM -1.05600760945889 0.128985072928026 no 2934 0.145482369176676 4198 747107 SGTC_651 3253-0966 34.4 µM -1.05612649430346 0.128958528377287 no 2935 0.145455213720516 4165 781462 SGTC_108 0509-0257 621.132 µM -1.06177848542638 0.127700924132661 no 2936 0.144168129540164 4114 536624 SGTC_1587 estradiol valerate 56.1 µM -1.06229880259681 0.127585580229816 no 2937 0.144050028917406 4206 13791 A steroid. SGTC_1105 epirubicin 18.1 µM -1.06458690187009 0.127079214135741 no 2938 0.14353145484028 4191 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1549 4'-methoxyflavonol 74.6 µM -1.06850290479928 0.126215834455359 no 2939 0.142646860390711 4106 97141 SGTC_1841 st054148 70 µM -1.06930608414367 0.12603926016386 no 2940 0.142465884993786 4191 675442 SGTC_3045 9092950 49.47 µM -1.07005336870567 0.125875128747193 no 2941 0.142297643541439 4098 44120432 SGTC_487 nimodipine 119 µM -1.07048455245205 0.125780492645426 no 2942 0.142200629282324 4114 4497 L-type voltage-gated calcium channels inhibitor SGTC_1043 0916-0009 19.3 µM -1.0709739006439 0.125673150762241 no 2943 0.142090582539001 4203 3101130 SGTC_2640 pentamidine 10.38 µM -1.07147209703407 0.125563933637983 no 2944 0.141978605205792 4149 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2817 7995342 71.43 µM -1.07170133358419 0.125513701501828 no 2945 0.141927100825242 4169 18879975 SGTC_1378 2093-0007 380 nM -1.07208198461529 0.125430321201664 no 2946 0.141841604907438 4229 3618014 SGTC_3056 9094900 49.47 µM -1.07253233153018 0.125331724195084 no 2947 0.141740500031356 4143 25236784 SGTC_2832 7992762 51.95 µM -1.07319182274677 0.125187435691869 no 2948 0.141592529431408 4110 2985177 SGTC_1873 rapamycin 2 nM -1.07348263622892 0.12512384617342 no 2949 0.141527312627127 4131 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.07448165607174 0.124905571523409 no 2950 0.141303431038656 4207 6708784 An antioxidant flavonoid SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.07489112190337 0.12481618473122 no 2951 0.141211738637351 4129 2333 A French combination drug. SGTC_772 k072-0172 35.3 µM -1.07831044726038 0.124071487633794 no 2952 0.140447618162621 4208 5861980 SGTC_2680 butyl paraben 22.24 µM -1.08228036917197 0.12321078259363 no 2953 0.139563983061536 4256 7184 An antifungal and steroid mimetic. SGTC_114 0364-0001 490.298 µM -1.08351822834829 0.122943264416243 no 2954 0.139289232200268 4224 4003655 SGTC_1896 st058441 89 µM -1.08418843120963 0.122798594531528 no 2955 0.139140630006586 4186 688759 SGTC_984 1492-0255 2.91 µM -1.08444395140995 0.122743469429347 no 2956 0.139084002653736 4144 1585198 SGTC_25 0118-0223 35.662 µM -1.084745230375 0.122678494778962 no 2957 0.139017254583678 4171 5333628 SGTC_1910 st062352 60.4 µM -1.08598010529552 0.122412430377307 no 2958 0.138743897105429 4076 2245730 SGTC_2716 st080858 38.6235 µM -1.0861350386301 0.122379077274017 no 2959 0.138709626230466 4155 5296050 SGTC_2521 angolensin 13.4 µM -1.08716920277851 0.122156612091532 no 2960 0.138481019349243 4219 821428 A flavenoid. SGTC_2077 5212015 200 µM -1.08761219217174 0.122061404932721 no 2961 0.13838317303453 4033 780900 SGTC_1397 3532-0190 20.1 µM -1.0881821164559 0.121938993623356 no 2962 0.138257359002894 4128 5322280 SGTC_3028 9087778 49.47 µM -1.09158026318663 0.121210911730862 no 2963 0.137508817585636 4162 17217395 SGTC_3315 9136395 68.55 µM -1.09559700020467 0.120354241381807 no 2964 0.136627587535442 4192 16876844 SGTC_718 1130-0073 349 µM -1.09560235570453 0.120353102040783 no 2965 0.136626415178524 4216 6740020 SGTC_1300 1094-0077 113 µM -1.09816439771947 0.119808918434459 no 2966 0.136066354667718 4162 5532636 SGTC_2593 nobiletin 86.24 µM -1.09889893118308 0.11965322233606 no 2967 0.135906076457864 4196 72344 An anti-infammatory. SGTC_77 0828-0286 12.516 µM -1.10258552496722 0.118873945443754 no 2968 0.135103599551642 4103 745345 SGTC_977 1348-1378 135 µM -1.10490212492933 0.118386097347625 no 2969 0.134601000792521 4179 X977 SGTC_520 3584-0023 682 µM -1.10554119133665 0.118251767057127 no 2970 0.13446257804553 4198 1340790 SGTC_3093 9117344 49.47 µM -1.10823174151231 0.117687401693704 no 2971 0.133880872905037 4234 24824913 SGTC_1048 3161-0300 24.5 µM -1.10937371496685 0.11744844042607 no 2972 0.133634498369711 4185 2165101 SGTC_1224 0823-0416 294 µM -1.10951799975703 0.117418272877738 no 2973 0.133603391911167 4274 3598164 SGTC_1735 st034310 56.75 µM -1.10970403204932 0.117379384720222 no 2974 0.13356329242835 4267 871153 SGTC_3190 9110366 49.47 µM -1.11143247352139 0.117018507624586 no 2975 0.133191120480809 4208 17123768 SGTC_3177 9107506 49.47 µM -1.11323183656245 0.116643658995936 no 2976 0.13280443637238 4156 8897194 SGTC_739 1486-1183 203 µM -1.11344807369521 0.116598669211848 no 2977 0.132758018981997 4206 4346692 SGTC_1925 st057770 10.1 µM -1.11553043358948 0.116166048129981 no 2978 0.132311592176952 4201 5989122 SGTC_1867 st057372 64 µM -1.1157462349438 0.116121279509994 no 2979 0.132265386838171 4172 688837 SGTC_1306 1185-0270 9.02 µM -1.1207708592616 0.115082366684004 no 2980 0.131192705615481 4251 1548076 SGTC_2666 tannic acid 100 µM -1.12512454834064 0.114187538113427 no 2981 0.130268130100903 4204 16134267 A thiamine antagonist. SGTC_2053 5265679 138 µM -1.12670739340895 0.113863442072251 no 2982 0.129933107735866 4135 764595 SGTC_1024 4507-0395 26 µM -1.12677151461457 0.113850326740034 no 2983 0.129919548530246 4276 4201836 SGTC_1427 4048-4900 550 nM -1.12694146012413 0.113815571344265 no 2984 0.129883616232517 4206 24132586 SGTC_2365 9042475 200 µM -1.13048695423242 0.113092209471944 no 2985 0.129135546244426 4288 6464479 SGTC_583 1488-1091 88.9 µM -1.13124166673972 0.112938655290968 no 2986 0.128976694503416 4330 4303273 SGTC_2175 5807670 165.306 µM -1.13155882221137 0.112874171111323 no 2987 0.128909980137427 4195 241186 SGTC_2561 acetosyringone 100 µM -1.13409824896976 0.112358801438966 no 2988 0.12837666902939 4200 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1267 0828-0272 9.49 µM -1.13564438140063 0.112045842791509 no 2989 0.128052713280077 4308 745334 SGTC_522 1273-0010 11.6 µM -1.13727442637823 0.111716574455923 no 2990 0.127711791046324 4307 5705015 SGTC_2994 9053520 71.4286 µM -1.13806595775276 0.111556935382642 no 2991 0.12754647083641 4277 4647384 SGTC_2331 7980721 200 µM -1.13847169008303 0.111475169043209 no 2992 0.127461786795221 4185 2981221 SGTC_1981 st071826 47 µM -1.13849615826832 0.111470239395524 no 2993 0.127456681070738 4264 11838600 SGTC_1122 capsaicin 818.572 nM -1.13869893843811 0.111429390927374 no 2994 0.127414372835075 4283 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3054 9094397 49.47 µM -1.14261660609154 0.110642309630607 no 2995 0.126598903880639 4223 2598354 SGTC_3096 9117468 49.47 µM -1.14442372865381 0.110280594607956 no 2996 0.126223976094649 4137 41316311 SGTC_2717 st081029 62.2815 µM -1.14451843067103 0.110261662393547 no 2997 0.126204349417065 4210 5292846 SGTC_588 3970-1144 52.9 µM -1.14985936453967 0.109197707462504 no 2998 0.125100899921149 4111 1888707 SGTC_2295 7971645 200 µM -1.15033974651595 0.10910237452607 no 2999 0.125001983175092 4293 2978226 YKL099C UTP11 SGTC_442 cape 100 µM -1.15411382779923 0.108355479548754 no 3000 0.124226752492428 4247 5281787 SGTC_1270 0831-1170 17.3 µM -1.15587969972508 0.108007277842573 no 3001 0.123865183597408 4266 6764716 SGTC_2496 diffractaic acid 79.83 µM -1.15889563106857 0.107414448822218 no 3002 0.123249364987185 4268 94870 An apoptosis inducer which activates caspases. SGTC_1602 st001878 87.6 µM -1.15956569722758 0.107283055754372 no 3003 0.123112836941121 4235 595405 YLR310C CDC25 SGTC_3334 9142812 21.919 µM -1.16142016427844 0.106920018103281 no 3004 0.1227355363382 4255 45283678 SGTC_684 1140-0066 328 µM -1.16238683580808 0.106731130518127 no 3005 0.122539184063345 4288 6813534 SGTC_10 0279-0212 42.575 µM -1.16240950138578 0.106726704556223 no 3006 0.122534582831369 4236 39851 YBR002C RER2 SGTC_1156 4092-0367 4.88 µM -1.16243726533446 0.106721283203645 no 3007 0.122528946768355 4277 1357585 SGTC_1500 4488-1866 171 µM -1.16547328606453 0.106129650419106 no 3008 0.121913733720113 4314 2900003 SGTC_419 nsc-638432 893 µM -1.16586381375472 0.106053720180205 no 3009 0.121834755765239 4210 368090 SGTC_1066 ketoconazole 628 nM -1.166034510279 0.106020544011485 no 3010 0.121800246425274 4318 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1610 st001799 48.1 µM -1.16654006628337 0.105922329350563 no 3011 0.121698079574002 4203 621897 SGTC_505 gw-5074 63.9 µM -1.17359064200868 0.104559457339864 no 3012 0.120279515646295 4288 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_981 1488-1094 54.9 µM -1.17422017018455 0.104438390533139 no 3013 0.120153424486801 4228 3449522 SGTC_954 1189-0853 2.85 µM -1.17675828925002 0.103951306112151 no 3014 0.119645997584857 4191 2828194 SGTC_2711 st079103 59.1 µM -1.17897675363903 0.103526916936947 no 3015 0.119203716279961 4218 54693780 SGTC_1339 1486-1321 22.7 µM -1.18070716905273 0.103196764814674 no 3016 0.118859536281791 4293 3469382 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.18147188545166 0.103051105696463 no 3017 0.118707657868913 4292 61125 An anti-inflammatory. SGTC_2126 5251174 33.877 µM -1.18166767684249 0.103013836415074 no 3018 0.118668794285484 4270 790722 SGTC_2634 4'-methoxyflavone 100 µM -1.18207202469234 0.102936898987331 no 3019 0.118588561773473 4277 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2354 9060492 162 µM -1.18210478262379 0.102930667789004 no 3020 0.118582063476851 4296 6471895 SGTC_629 3448-6466 76.7 µM -1.18383688729578 0.102601577874339 no 3021 0.118238818627154 4271 573744 SGTC_853 0419-0306 21 µM -1.18580007925649 0.102229508182698 no 3022 0.117850630109668 4287 762713 SGTC_8 0354-0001 70 µM -1.19086558203549 0.101274015052557 no 3023 0.116853179008341 4267 4993152 SGTC_2283 7944793 200 µM -1.19195573386459 0.101069236054825 no 3024 0.116639301370031 4292 2970533 SGTC_89 0302-0250 142.109 µM -1.19598328491908 0.100315300129649 no 3025 0.115851540994859 4378 4203518 YLR208W SEC13 SGTC_3195 9113082 49.47 µM -1.19739069968475 0.100052809837284 no 3026 0.115577153471885 4280 17018038 SGTC_450 aminopyrene 156 nM -1.19739592805216 0.100051835655011 no 3027 0.115576135018524 4242 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1987 st072290 61.9 µM -1.19848655005206 0.0998487754856941 no 3028 0.115363828019277 4298 54697379 SGTC_534 k292-0788 63.4 µM -1.20028263298973 0.0995150236677346 no 3029 0.115014796143215 4337 4146317 SGTC_1150 3909-7983 10.9 µM -1.20167804513471 0.0992562886605883 no 3030 0.114744145267098 4269 23965914 SGTC_1648 st011736 69.8 µM -1.20646135759246 0.0983731079844431 no 3031 0.113819825073949 4283 2855514 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -1.20679638933657 0.0983114647827398 no 3032 0.113755283463718 4229 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1088 bifonazole 369 nM -1.20708044367539 0.0982592231869398 no 3033 0.113700582744844 4257 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2533 agelasine 13.65 µM -1.20822463348364 0.0980489964655655 no 3034 0.113480434482458 4359 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1821 st053465 65.6 µM -1.21086701457064 0.0975647606365407 no 3035 0.112973188140165 4309 675086 SGTC_682 0kpi-0099 17 µM -1.21091974015546 0.0975551161629348 no 3036 0.112963083134621 4308 1714895 YML126C ERG13 SGTC_511 blebbistatin 171 µM -1.21117586239092 0.0975082766697049 no 3037 0.112914005771495 4340 3476986 A myosin inhibitor. SGTC_749 1000-0129 128 µM -1.2124187702954 0.0972812085797318 no 3038 0.112676059683628 4341 708470 SGTC_2610 ononetin 44.17 µM -1.21481654260898 0.0968442537703778 no 3039 0.112218035010255 4271 259632 SGTC_719 2810-4230 27.3 µM -1.2175441027789 0.0963489545694974 no 3040 0.111698633553152 4305 721079 SGTC_3119 9125183 49.47 µM -1.21982133092372 0.0959368594333092 no 3041 0.111266306639833 4129 22695334 SGTC_1743 st037606 46.3785 µM -1.2215933798863 0.0956170811970512 no 3042 0.110930716675935 4270 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2898 9056270 58.44 µM -1.22254337236151 0.0954459719040439 no 3043 0.110751106288423 4297 19154699 SGTC_1921 5740136 50 µM -1.23346883439212 0.0934942937722479 no 3044 0.108700448673272 4255 1774243 SGTC_3151 9099821 49.47 µM -1.23581028761854 0.0930798890253049 no 3045 0.108264545030422 4262 17174189 SGTC_373 0844-0104 25.9 µM -1.23741865925788 0.0927960171394932 no 3046 0.107965847520768 4332 5375804 SGTC_2831 7999036 19.48 µM -1.23957278601881 0.0924168249883478 no 3047 0.107566725794954 4328 2988270 SGTC_2384 9036245 200 µM -1.24974018832101 0.0906425199934234 no 3048 0.105697235738445 4254 6462766 SGTC_3317 9138495 8.753 µM -1.25138863355655 0.0903572492894277 no 3049 0.105396361098664 4238 17020139 SGTC_2474 5321570 43.32 µM -1.25190374939775 0.0902682430911403 no 3050 0.105302469192283 4312 2841384 SGTC_2050 5263056 171 µM -1.25434100329642 0.0898479959710762 no 3051 0.104859043164449 4317 763468 YGL055W OLE1 SGTC_2736 butenafine 14.65 µM -1.25472346244568 0.0897821821015155 no 3052 0.104789582698401 4270 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2397 5161689 200 µM -1.26277646802864 0.0884047238800201 no 3053 0.103334761952063 4396 2259942 SGTC_2948 9070189 9.45 µM -1.26309571689139 0.0883504430237801 no 3054 0.103277391544933 4278 6473636 YDL196W YDL196W SGTC_2517 totarol 10 µM -1.2699420190888 0.0871923581577178 no 3055 0.102052642077906 4337 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.27192607793002 0.0868588728499086 no 3056 0.101699692631571 4366 94937 An inhibitor of serotonin biosynthesis. SGTC_2357 9067248 200 µM -1.27284988108628 0.0867039233742574 no 3057 0.101535658435584 4306 9150235 SGTC_1007 4101-0031 70 µM -1.27411299223416 0.0864923962297809 no 3058 0.101311687308876 4334 1146276 SGTC_645 0845-0943 5.41 µM -1.27453883398194 0.0864211695925479 no 3059 0.101236259502017 4361 1885106 SGTC_3211 9128781 49.47 µM -1.27579784593467 0.0862108427443661 no 3060 0.101013494616917 4307 17194361 SGTC_1749 st037932 54.2 µM -1.27584235141662 0.0862034148016304 no 3061 0.101005626526627 4373 594497 SGTC_1137 ixabepilone 100 µM -1.27615445055074 0.0861513390604197 no 3062 0.100950463308958 4301 154225 A novel microtubule stabilizer. SGTC_1917 st066507 28.5 µM -1.27630155403813 0.0861268020621647 no 3063 0.100924470527965 4293 3156428 SGTC_1249 0481-0015 10.2 µM -1.27761109099771 0.0859086004626207 no 3064 0.10069329398479 4271 4227577 SGTC_961 1252-1571 372 µM -1.27993784283265 0.0855219264093173 no 3065 0.100283498567409 4354 6813498 SGTC_2828 7998861 71.43 µM -1.281281742921 0.085299183364507 no 3066 0.100047361607936 4347 2988188 SGTC_1871 st057448 67.3 µM -1.28139604120597 0.0852802592104527 no 3067 0.100027296982119 4377 691747 SGTC_2791 5663188 71.43 µM -1.28671907695521 0.0844024144748852 no 3068 0.0990961106730497 4374 54690634 SGTC_1132 3456-3614 2.5 µM -1.2869202000085 0.0843693798353984 no 3069 0.0990610518957961 4369 3125502 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.29330772166777 0.0833252641023769 no 3070 0.0979523255428931 4406 91467 include heat shock SGTC_1303 1160-0052 261 µM -1.30255983292558 0.0818301636732637 no 3071 0.0963625391976859 4312 3562476 SGTC_665 3914-0008 307 µM -1.30642584858281 0.0812114563435983 no 3072 0.0957038901579583 4333 1069549 SGTC_1767 st044992 70.3 µM -1.30733950965965 0.0810657533102887 no 3073 0.095548715701034 4412 9600693 SGTC_2556 citropten 84.59 µM -1.31691858009556 0.0795500203797984 no 3074 0.0939329588807311 4400 2775 A potential DNA crosslinker. SGTC_1567 st069303 68.4 µM -1.31707384746563 0.0795256296693461 no 3075 0.0939069361464058 4404 5581319 SGTC_1404 3909-7820 48.3 µM -1.31811966955999 0.0793614905063881 no 3076 0.0937317954834113 4366 23741373 SGTC_710 3448-4187 58 µM -1.31833703120594 0.0793274083491822 no 3077 0.0936954248740288 4348 3946412 SGTC_531 3788-1495 174 µM -1.31996439360986 0.0790725909570865 no 3078 0.0934234531585961 4367 2896655 SGTC_3212 9128307 49.47 µM -1.32012305713012 0.0790477801396941 no 3079 0.0933969678686041 4289 27243542 SGTC_1872 amphotericin b 148 nM -1.32557375554325 0.0781990096832129 no 3080 0.0924904620302531 4388 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1809 st050081 57.6 µM -1.32616929463153 0.0781066941629497 no 3081 0.0923918137446684 4454 5036894 SGTC_144 4161-2749 112.381 µM -1.32746963790086 0.0779054131114619 no 3082 0.0921766885554157 4353 797501 YMR168C CEP3 SGTC_418 lividomycin a 100 µM -1.32796491090647 0.0778288530505365 no 3083 0.0920948495448899 4388 72394 An antibiotic. SGTC_744 1594-0068 283 µM -1.33033305524261 0.0774635707505901 no 3084 0.0917042803757626 4370 668392 SGTC_3292 9120825 59.784 µM -1.33100710261971 0.0773598384771296 no 3085 0.0915933369434308 4374 24824900 SGTC_1220 1838-0075 193 µM -1.33411268698447 0.0768832682647926 no 3086 0.0910834642775617 4316 5529645 SGTC_2463 5473429 200 µM -1.33644747933301 0.0765264527977344 no 3087 0.0907015281342285 4378 5399405 SGTC_248 streptozotocin 5.23457 mM -1.338059699254 0.0762808009016201 no 3088 0.0904384883445467 4417 5300 DNA alkylating agent. SGTC_2592 piperlongumine 83.33 µM -1.34017261424655 0.0759597678898791 no 3089 0.0900946163910648 4384 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1435 4092-0789 56.7 µM -1.34038196022607 0.0759280162858335 no 3090 0.0900605987871575 4380 2248285 SGTC_3297 9117502 71.43 µM -1.34271751970908 0.0755744658974569 no 3091 0.089681729769746 4410 7453720 SGTC_1325 1431-0015 227 µM -1.34334079890517 0.0754803280241364 no 3092 0.0895808234676096 4408 1103340 SGTC_918 glabranin 770.725 nM -1.34359789450185 0.0754415232620158 no 3093 0.0895392253667627 4403 124049 Also referred to as licorice root. SGTC_1450 4112-4260 37.6 µM -1.34903421872555 0.0746245461861709 no 3094 0.0886629876480341 4392 1633175 SGTC_2448 5185112 27.17 µM -1.35069296828724 0.0743766166541611 no 3095 0.0883969028568298 4402 5718189 SGTC_2260 7964312 200 µM -1.35075102585414 0.0743679503270033 no 3096 0.0883876004649231 4455 231951 SGTC_2976 9009005 19.48 µM -1.35251925632772 0.074104373490256 no 3097 0.0881046314538139 4408 2993148 SGTC_264 promethazine 12.5 mM -1.35579381589951 0.0736181447334789 no 3098 0.0875823897398521 4278 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2909 7941780 10.49 µM -1.35935478986697 0.0730921598100525 no 3099 0.0870170949816325 4366 1243215 SGTC_2195 6536160 144.242 µM -1.36494877951212 0.0722716957303374 no 3100 0.0861345746187573 4394 3834386 SGTC_1626 st003712 1.76 µM -1.36498716398812 0.0722660904050953 no 3101 0.0861285422136266 4435 24207035 SGTC_2747 doxorubicin 7.63 µM -1.36722639003121 0.0719396701740308 no 3102 0.0857771779921991 4448 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3300 9124615 50.48 µM -1.36814635102428 0.0718058921884268 no 3103 0.0856331352950311 4449 24824903 SGTC_2097 5376186 200 µM -1.36924731154172 0.0716460446897363 no 3104 0.0854609907884948 4392 742755 SGTC_518 1021-0119 62.6 µM -1.3697318307299 0.0715757843369296 no 3105 0.0853853142891799 4385 1097762 SGTC_3136 9095672 49.47 µM -1.37407184525076 0.0709487924651293 no 3106 0.0847096895478944 4266 17217380 SGTC_2174 5790901 200 µM -1.37444785671879 0.0708946701688029 no 3107 0.0846513438255347 4392 786020 SGTC_2426 5582046 32.21 µM -1.37482047171624 0.0708410680463443 no 3108 0.0845935548722727 4411 2251934 SGTC_2515 chrysin 20.77 µM -1.378151449312 0.0703632762759908 no 3109 0.0840782667562212 4429 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_68 0986-0284 82.829 µM -1.37852600046531 0.0703097064130989 no 3110 0.0840204729832184 4430 423278 YIL048W NEO1 SGTC_1736 st036774 51 µM -1.38168972753313 0.0698584675179748 no 3111 0.0835334949336173 4466 1272247 SGTC_1857 st056007 79.3 µM -1.385405324614 0.0693313655723675 no 3112 0.0829642818908869 4393 619834 SGTC_2489 cantharidin 73.42 µM -1.38608569199065 0.0692351800246018 no 3113 0.0828603694022285 4384 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1019 4262-0212 3.4 µM -1.38788676782698 0.0689810529051697 no 3114 0.0825857638691131 4428 4677213 SGTC_1759 st043059 70 µM -1.38812788963831 0.0689470858831467 no 3115 0.0825490526816629 4424 669426 SGTC_468 gf-109203x 121 µM -1.38830423019493 0.0689222528113997 no 3116 0.0825222123234133 4478 2396 A protein kinase C inhibitor. SGTC_2997 9067075 71.4286 µM -1.38874323652478 0.06886045991049 no 3117 0.0824554207966949 4391 27209819 SGTC_2712 st079126 47.7 µM -1.3928991518377 0.0682776028485784 no 3118 0.0818251444825702 4418 3152970 SGTC_2866 9034245 58.44 µM -1.39519622043793 0.0679570823438607 no 3119 0.0814783382328088 4437 6462273 SGTC_19 0279-0214 38.434 µM -1.39993842031088 0.0672990579034828 no 3120 0.0807658798020055 4503 3566274 YBR002C RER2 SGTC_814 3342-0569 96 µM -1.40494443201087 0.0666097827240309 no 3121 0.0800189013724504 4467 4346283 SGTC_1761 st044296 37 µM -1.4078509268234 0.0662121034947586 no 3122 0.0795876083623025 4450 1826700 SGTC_2451 5856223 45.7 µM -1.40850385633061 0.0661230203142489 no 3123 0.0794909629369517 4432 2179896 SGTC_1663 st014140 55.4 µM -1.40927980743967 0.0660172733080139 no 3124 0.0793762236013211 4510 4207120 SGTC_1958 st076513 41.9 µM -1.4174486544584 0.0649119547677382 no 3125 0.0781758980761368 4393 732122 YGL099W LSG1 SGTC_1776 st049249 45.9 µM -1.41978700640328 0.0645982141813061 no 3126 0.077834849443023 4463 1822314 SGTC_2444 5485484 36.41 µM -1.4213158540693 0.0643937237845773 no 3127 0.0776124782660323 4506 6790631 SGTC_3047 9092122 49.47 µM -1.42158109946595 0.064358297253367 no 3128 0.0775739474242311 4439 17173831 SGTC_681 1642-0006 26.6 µM -1.42166680346205 0.0643468537505767 no 3129 0.0775615007483366 4461 4446530 SGTC_1260 0700-1617 7.75 µM -1.42301543340366 0.0641669880126154 no 3130 0.0773658406593602 4418 2853078 SGTC_78 0336-0123 156.75 µM -1.42354485881655 0.0640964858715399 no 3131 0.0772891338423384 4299 6765896 SGTC_1531 st059297 52.4 µM -1.42591058857864 0.0637821836345534 no 3132 0.0769470762968997 4477 7566702 SGTC_1229 0139-0193 12.2 µM -1.42687691079392 0.0636541469668112 no 3133 0.0768076885943741 4510 3090752 SGTC_210 3551-0445 56.827 µM -1.42740647307114 0.0635840653993724 no 3134 0.076731383054071 4455 2865180 YOR207C RET1 SGTC_3049 9092223 49.47 µM -1.42864618439889 0.0634202384522483 no 3135 0.0765529763556106 4444 8623917 SGTC_86 0417-1630 471.922 µM -1.43333652968933 0.0628033842943656 no 3136 0.0758808436654369 4426 3634867 SGTC_2022 5136654 200 µM -1.43441396836198 0.0626623466558001 no 3137 0.0757270819184377 4457 1713771 SGTC_341 1486-1430 230 µM -1.43543386257309 0.0625290691896326 no 3138 0.0755817511396457 4410 2054753 YPL210C SRP72 SGTC_2472 5377652 49.4 µM -1.43859639756031 0.0621172010711266 no 3139 0.075132453813578 4501 1610903 SGTC_230 MPP+ 141.667 µM -1.4412816334801 0.0617691574294308 no 3140 0.0747525669526426 4430 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_576 1073-0113 22.7 µM -1.44533637609982 0.0612464940619053 no 3141 0.0741817125107146 4546 5439563 SGTC_797 k781-0471 270 µM -1.44863432119537 0.0608239369277115 no 3142 0.0737198655796911 4440 23738129 SGTC_3 0833-0587 95.581 µM -1.45247977247794 0.0603341118740194 no 3143 0.0731841247498294 4346 5382644 SGTC_3090 9117696 49.47 µM -1.45520509437931 0.0599888396796808 no 3144 0.0728062454885885 4420 7923821 SGTC_2443 5493264 126.67 µM -1.46201174090013 0.059133260584342 no 3145 0.0718689962635732 4509 5340055 SGTC_2103 5378138 10 µM -1.46300307652745 0.0590094545243283 no 3146 0.0717332685591217 4545 244142 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.46357410029755 0.0589382327848039 no 3147 0.0716551767188449 4466 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2362 9071156 126 µM -1.46492279850537 0.0587702822853112 no 3148 0.0714709909413731 4476 653133 SGTC_2576 guaiol 23.12 µM -1.46557502331775 0.0586891969841661 no 3149 0.0713820499075881 4376 227829 SGTC_807 1315-0151 48 µM -1.4656704732361 0.058677337915563 no 3150 0.0713690409503067 4481 4011080 SGTC_2435 5706476 10.6 µM -1.46912274854475 0.0582496768324478 no 3151 0.0708997492980174 4463 5725375 SGTC_2044 5102272 200 µM -1.4700277227136 0.058137976445613 no 3152 0.0707771229120432 4473 592666 SGTC_2744 captopril 92.04 µM -1.47210818559341 0.0578818244392682 no 3153 0.0704958327054244 4548 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1133 3473-0247 50 µM -1.47955921622234 0.0569717063671339 no 3154 0.0694954586375881 4450 711311 SGTC_2149 5554786 194.827 µM -1.48673441400057 0.0561059667715964 no 3155 0.0685424848406465 4514 745063 YPR165W RHO1 SGTC_1652 st011932 78 µM -1.48681664160801 0.056096105881839 no 3156 0.0685316224998452 4420 1551076 SGTC_789 1309-1135 70.6 µM -1.48746892056817 0.056017931774143 no 3157 0.0684455029034421 4471 3092424 SGTC_2288 7946289 167.31 µM -1.48824088550832 0.0559255246304801 no 3158 0.0683436892184394 4503 1246052 SGTC_1820 st053765 18.6 µM -1.488948272536 0.0558409533288583 no 3159 0.0682504952950038 4507 3690829 SGTC_3236 9132701 49.47 µM -1.49303733740209 0.0553540630053854 no 3160 0.0677137068120391 4490 24282524 SGTC_1621 st003705 32.4 µM -1.49472356329087 0.0551542607378673 no 3161 0.0674933010277473 4494 24207032 SGTC_3048 9093155 49.47 µM -1.49531126492389 0.0550847575320545 no 3162 0.0674166132501274 4461 25236002 SGTC_2620 irigenin 100 µM -1.49572081183227 0.0550363643176266 no 3163 0.067363212285392 4481 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2963 9082507 9 µM -1.49747330255682 0.054829664395007 no 3164 0.0671350736313569 4494 16459611 SGTC_1020 4335-0961 93.3 µM -1.50035223719526 0.0544914369995169 no 3165 0.0667615924050812 4461 669075 SGTC_2250 alverine citrate 130 µM -1.50742800822831 0.0536671611934469 no 3166 0.0658504920552289 4371 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2082 5219693 150 µM -1.51355587508073 0.0529613174371443 no 3167 0.0650692597882534 4457 2834649 SGTC_1432 4049-0298 68.4 µM -1.51394669955271 0.0529165509312369 no 3168 0.0650196792425288 4523 741646 SGTC_618 k072-0232 33.2 µM -1.51444447129538 0.0528595777450292 no 3169 0.0649565736769243 4531 5872756 YGL099W LSG1 SGTC_2478 5763493 32.33 µM -1.51504244836523 0.0527911997628191 no 3170 0.0648808273449807 4450 1365576 YLR208W SEC13 SGTC_3084 9116877 49.47 µM -1.51776748654045 0.0524804829349457 no 3171 0.0645365121258555 4456 27241325 SGTC_2473 5854593 8.94 µM -1.51879578491301 0.0523636112927178 no 3172 0.0644069536135989 4446 2872951 SGTC_1496 4469-0713 57.4 µM -1.52005916096765 0.0522203048200204 no 3173 0.0642480537116885 4495 746691 SGTC_2619 obliquin 87.91 µM -1.52187141433183 0.0520152824934138 no 3174 0.0640206515139435 4483 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1461 k072-0203 53.8 µM -1.52667630909369 0.0514747938626567 no 3175 0.0634207606432618 4398 5418714 SGTC_2369 9071472 200 µM -1.5301012131625 0.0510922699701814 no 3176 0.0629958390105188 4514 17296037 SGTC_1986 st071812 45 µM -1.53083734615437 0.0510103481684482 no 3177 0.0629047985355974 4452 11838594 SGTC_2557 derrustone 83.84 µM -1.53554545519624 0.0504888682346977 no 3178 0.062324950299264 4489 629853 An antioxidant. SGTC_2861 9024595 19.48 µM -1.53785299821922 0.050234835562617 no 3179 0.0620422808692082 4459 16482810 SGTC_869 0564-0080 44.1 µM -1.53835429723688 0.0501797835136018 no 3180 0.0619810052012586 4500 6843321 SGTC_606 k015-0008 38.6 µM -1.54482634166171 0.049473341600252 no 3181 0.0611941369441455 4579 1970475 SGTC_919 tnp00227 403.569 nM -1.54531322967773 0.0494205190923082 no 3182 0.0611352584847287 4483 1269246 A methoxyflavone. YNL221C POP1 SGTC_1836 st055642 81 µM -1.54689859059835 0.0492488351003125 no 3183 0.0609438504914556 4508 8571 SGTC_1361 1608-0041 5.61 µM -1.5494348947329 0.0489751611045679 no 3184 0.0606386054267299 4524 X1361 SGTC_2978 9011784 42.97 µM -1.5559841942791 0.0482740915724934 no 3185 0.0598559254431035 4508 2994934 SGTC_1521 st012942 49.4 µM -1.56387949096523 0.0474396378425997 no 3186 0.0589229358767305 4444 24207259 SGTC_2755 lomerizine 42.69 µM -1.5655897911509 0.0472604079906596 no 3187 0.0587223407511314 4474 3949 A calcium channel blocker. SGTC_1557 sumaresinolic acid 42.3 µM -1.56975635753267 0.0468260463784988 no 3188 0.0582359021671669 4504 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3231 9132313 49.47 µM -1.57179335297083 0.0466148595718352 no 3189 0.0579992417974299 4492 4905967 SGTC_2906 7926292 26.41 µM -1.57288005684932 0.0465025078770827 no 3190 0.0578732968846046 4524 2966319 SGTC_2199 6590217 200 µM -1.58025398850461 0.0457458648206007 no 3191 0.0570243561698095 4503 703109 SGTC_379 3970-0972 5.9 µM -1.5818834506783 0.0455800070188587 no 3192 0.0568380897954816 4538 2898042 YBL034C STU1 SGTC_3260 9137109 49.47 µM -1.58206351295343 0.0455617087525049 no 3193 0.0568175360294877 4518 17478346 SGTC_870 0573-2213 57.6 µM -1.58272138662647 0.0454949046008653 no 3194 0.0567424907627497 4525 3916321 SGTC_2192 5915882 198.485 µM -1.58732573387786 0.0450295555783213 no 3195 0.0562194449008768 4528 2876149 SGTC_3087 9117406 49.47 µM -1.58941117258618 0.0448200501733102 no 3196 0.0559837969176676 4533 42546093 SGTC_3346 9158254 43.5805 µM -1.59291025043413 0.0444702928464068 no 3197 0.055590163216634 4578 17639500 SGTC_2238 6671620 73.2395 µM -1.59382734767361 0.0443789871913808 no 3198 0.0554873552379856 4456 729941 SGTC_1654 st012436 41.8 µM -1.60102739221888 0.0436673927955321 no 3199 0.0546854261304563 4547 4323132 SGTC_2966 9084041 48.03 µM -1.61032839115462 0.042761816847305 no 3200 0.0536630921634112 4499 17741380 SGTC_4 0960-0234 25.671 µM -1.61117378292327 0.0426802648800336 no 3201 0.0535709251648303 4534 6821112 SGTC_3284 9108171 64.8615 µM -1.62695729217625 0.0411806425437961 no 3202 0.0518730842977596 4535 8687505 SGTC_1330 1469-0054 61.8 µM -1.63367269714238 0.0405556891539036 no 3203 0.05116379710917 4527 7102664 SGTC_1291 0993-0025 5.79 µM -1.64239080231254 0.0397558677926913 no 3204 0.0502545199194843 4552 4353356 SGTC_3200 9114385 49.47 µM -1.64456982975945 0.0395579743963303 no 3205 0.0500292764374024 4528 17018030 YLR208W SEC13 SGTC_2919 7978188 46.38 µM -1.64912321127529 0.0391470346852071 no 3206 0.0495611976452734 4572 2980291 SGTC_998 3996-0085 177 µM -1.65628387918085 0.0385078240623596 no 3207 0.0488321717884909 4597 715391 SGTC_2033 5192550 145 µM -1.65668395453843 0.0384723629709494 no 3208 0.0487916943429676 4574 182073 SGTC_774 k060-0086 136 µM -1.65878867368968 0.0382862471041781 no 3209 0.0485791917345353 4580 5911235 SGTC_3027 9089541 49.47 µM -1.66707890654868 0.0375602875083079 no 3210 0.0477493579145546 4566 9943819 SGTC_2825 7998094 58.44 µM -1.66810381894344 0.0374713237694319 no 3211 0.0476475596061032 4549 2987815 SGTC_2302 7771753 200 µM -1.66967273159812 0.0373354734964782 no 3212 0.0474920658318312 4551 2203047 SGTC_2274 7947094 46.08 µM -1.67091110758674 0.0372285283458405 no 3213 0.0473696186036944 4547 2971028 SGTC_2084 5306078 60.6385 µM -1.67111221406974 0.0372111845993699 no 3214 0.0473497576432442 4519 679340 SGTC_428 3448-4153 16.5 µM -1.67133475057896 0.0371920003884199 no 3215 0.0473277880651807 4544 3834874 SGTC_433 pimozide 108 µM -1.67832829671755 0.0365932137170869 no 3216 0.0466415134566761 4505 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2644 guaiazulene 100 µM -1.6930421687476 0.0353591543215419 no 3217 0.0452237204372126 4623 3515 A coloring agent. SGTC_296 1222-0039 74.9 µM -1.69956751667025 0.0348229017943429 no 3218 0.0446061523715282 4600 5984176 SGTC_2376 9072922 81.32 µM -1.69995874618107 0.0347909639122661 no 3219 0.0445693427782051 4572 17087968 SGTC_98 0074-0023 107.663 µM -1.70143050531041 0.0346710327261818 no 3220 0.0444310885555562 4581 3563821 SGTC_2176 5809774 33.9695 µM -1.70422772502585 0.0344440278945868 no 3221 0.0441692757325446 4522 2870539 SGTC_703 3875-0075 71.8 µM -1.72333040328659 0.0329262200314312 no 3222 0.0424143963512899 4637 2850814 SGTC_759 3486-0358 89.3 µM -1.72803724278928 0.0325608243083225 no 3223 0.0419907737755063 4580 875103 SGTC_1719 st032227 49.2 µM -1.7319422502426 0.0322602198071997 no 3224 0.0416419225852149 4582 3125804 SGTC_307 1501-1223 22.3 µM -1.73289340379869 0.0321873486569701 no 3225 0.041557308453341 4614 2830329 SGTC_3278 9139605 49.47 µM -1.73330844425795 0.0321555935854108 no 3226 0.0415204303458367 4574 7958859 SGTC_2939 9044578 71.43 µM -1.73910785995609 0.0317145749023312 no 3227 0.0410078961841192 4538 2653634 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -1.74203424022078 0.0314939415369766 no 3228 0.0407512265122954 4629 66535 A nucleotide analog. SGTC_1305 1181-0477 144 µM -1.74685051273571 0.03113358390009 no 3229 0.0403316359392443 4631 6252086 SGTC_2999 9069765 71.4286 µM -1.7641938482554 0.0298640876170076 no 3230 0.0388496740546737 4575 2097066 SGTC_2393 9031399 185.94 µM -1.77428445211711 0.0291454426336518 no 3231 0.0380080555089779 4597 1526623 YDL150W RPC53 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.78329815636689 0.0285156983593549 no 3232 0.037268890684375 4601 756377 SGTC_1245 0418-0076 17.2 µM -1.78836641829196 0.028166602712769 no 3233 0.0368584552821351 4618 6790114 SGTC_579 4491-1009 110 µM -1.79298015176124 0.0278519151071089 no 3234 0.0364880489165271 4663 1271041 SGTC_2019 4016004 108 µM -1.79947837091505 0.0274136654177552 no 3235 0.0359715211498245 4619 45595336 SGTC_2212 7123476 200 µM -1.81025793239176 0.0266993632588584 no 3236 0.0351278987180687 4675 1085715 SGTC_430 0958-0115 16.4 µM -1.81149224680564 0.0266185729738309 no 3237 0.0350323440732515 4565 6833180 SGTC_2447 5741742 33.78 µM -1.81810563544791 0.0261891737607174 no 3238 0.0345239944206152 4672 1776504 SGTC_825 1988-2224 89.6 µM -1.8261939960272 0.0256718950012198 no 3239 0.0339105227062741 4628 1180859 SGTC_1460 k062-0059 9.15 µM -1.83353336700915 0.0252099449885531 no 3240 0.0333616455750428 4516 1373085 SGTC_1510 1123-0200 71.5 µM -1.8347415772616 0.0251345703781996 no 3241 0.0332719943476734 4630 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_3071 9117417 49.47 µM -1.8374847272131 0.0249641390589005 no 3242 0.033069184543867 4605 45595590 YGL055W OLE1 SGTC_2065 5221596 34.26 µM -1.8486292287184 0.0242816662461063 no 3243 0.0322556845858005 4611 788581 SGTC_1154 4088-0362 150 µM -1.84962834867431 0.0242212543119232 no 3244 0.0321835670105841 4658 6618304 SGTC_2035 5154463 94.595 µM -1.86522537723506 0.0232944272420967 no 3245 0.0310749099319388 4655 2769623 SGTC_2172 5754775 163.918 µM -1.87226237485941 0.0228861414059194 no 3246 0.0305851566998874 4633 2263357 SGTC_1506 4226-2149 212 µM -1.88574169273122 0.022120896319423 no 3247 0.0296648857996388 4652 991114 SGTC_2085 5307070 144.047 µM -1.91875364684359 0.0203374846507889 no 3248 0.0275077593211603 4615 2840351 SGTC_2029 5175081 200 µM -1.9252572671739 0.0200009007049891 no 3249 0.0270985904326512 4622 1380876 SGTC_2626 ethyl orsellinate 100 µM -1.92843863358002 0.0198379831393768 no 3250 0.0269002951651684 4605 75653 A natural product. SGTC_1868 st057644 42.7 µM -1.93122120384101 0.0196964125621562 no 3251 0.0267278514452399 4682 688665 SGTC_43 0570-0105 72.5 µM -1.93625938317666 0.0194422640090498 no 3252 0.0264179703514337 4634 1114046 YDL195W SEC31 SGTC_1151 3909-8316 15.3 µM -1.93931866527369 0.019289303550226 no 3253 0.026231273731043 4685 800431 SGTC_881 0833-0569 170 µM -1.9433036314225 0.019091594710111 no 3254 0.0259897415043813 4679 5418700 SGTC_2147 5545932 89.7195 µM -1.94426880184042 0.0190439690907026 no 3255 0.0259315223839065 4703 797404 SGTC_1246 0422-0085 105 µM -1.94744129111828 0.0188881361461412 no 3256 0.0257409259036885 4635 264295 SGTC_2347 9049783 174.81 µM -1.94985413843738 0.0187703443329851 no 3257 0.0255967533348909 4639 6467988 YPL169C MEX67 SGTC_2840 9008771 71.43 µM -1.95169896534654 0.0186807046895596 no 3258 0.0254869777633586 4642 2992978 SGTC_1314 1222-0010 41.1 µM -1.95304224310828 0.0186156646533517 no 3259 0.0254072949287899 4678 3526027 SGTC_1903 st060211 78.3 µM -1.95884585264203 0.0183368714370727 no 3260 0.0250654209419638 4683 688960 SGTC_882 0843-0131 351 µM -1.95892885438157 0.0183329101483369 no 3261 0.0250605596550418 4693 5425421 SGTC_2772 vinpocetine 57.06 µM -1.96474340191605 0.0180572172149187 no 3262 0.0247219719239174 4663 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_330 1488-0319 80.1 µM -1.9662005875254 0.0179886822131986 no 3263 0.0246377223233121 4693 6846614 SGTC_1832 st054113 55 µM -1.97287059880806 0.0176777995358162 no 3264 0.0242551535610135 4698 1251267 SGTC_2407 paclitaxel 400 µM -1.97348470295347 0.0176494086304095 no 3265 0.0242201828451035 4673 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1162 k048-0130 20.1 µM -1.98664516440046 0.0170502690321026 no 3266 0.0234808662484448 4687 6797406 SGTC_892 0929-0076 29 µM -1.98728164619271 0.0170217388805756 no 3267 0.0234455972078865 4690 5751038 SGTC_2555 cholic acid 100 µM -1.99813264634711 0.0165415878633882 no 3268 0.022851140619578 4648 6708657 Influences liver metabolism. SGTC_2647 atorvastatin 60.16 µM -2.0029456142317 0.0163323563111752 no 3269 0.0225915631595746 4689 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_913 3487-1245 167 µM -2.011621969073 0.0159608968757015 no 3270 0.0221299008794577 4629 4016153 SGTC_980 1473-0395 201 µM -2.0123219010232 0.015931249025961 no 3271 0.0220930076108585 4650 768876 SGTC_427 1354-0053 47.3 µM -2.01862393294012 0.0156664262270866 no 3272 0.0217631607854163 4689 6813657 SGTC_818 4072-2707 53.5 µM -2.02662356128724 0.0153357146318809 no 3273 0.0213504625502456 4644 882871 SGTC_377 3970-0964 33.1 µM -2.02934393903947 0.0152246262695822 no 3274 0.0212116354313209 4684 16481235 SGTC_817 1391-0715 46 µM -2.03061239680564 0.0151730647349652 no 3275 0.0211471645880639 4687 1353946 SGTC_1006 4099-6547 255 µM -2.04333939110922 0.0146639761080736 no 3276 0.0205094263735193 4706 3146833 SGTC_751 0833-0568 350 µM -2.04948440077215 0.0144234782327312 no 3277 0.0202073858316491 4698 6954252 SGTC_2236 dapsone 200 µM -2.05191740734004 0.0143292001182181 no 3278 0.0200888449136288 4707 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1238 0333-0287 48.8 µM -2.06713488212244 0.0137514855842051 no 3279 0.0193607230152219 4720 7226 SGTC_597 k018-0003 82.8 µM -2.0767076753246 0.0133984538378676 no 3280 0.0189142738868521 4734 6786234 SGTC_150 3970-0969 77.2 µM -2.08680196786519 0.0130346943034571 no 3281 0.0184530195951636 4694 6615640 SGTC_1022 4477-0945 21.3 µM -2.09986014010568 0.0125768164585028 no 3282 0.0178705730073423 4666 4648966 SGTC_1171 0368-0077 21.4 µM -2.10282328694372 0.0124748751592254 no 3283 0.017740609808903 4704 3239779 SGTC_1891 st059073 26.2 µM -2.10734468203523 0.0123207043170092 no 3284 0.0175438564473603 4730 688754 SGTC_2218 6965428 192.983 µM -2.10969514401973 0.0122412121676125 no 3285 0.0174423115209625 4653 675684 SGTC_2188 6126565 140.678 µM -2.12354897176698 0.0117816497106016 no 3286 0.0168539381836737 4673 874518 SGTC_2000 st075254 36.4 µM -2.12789553686678 0.0116405843967645 no 3287 0.0166728728609175 4661 17234175 SGTC_2340 7987427 183.45 µM -2.15613141494096 0.0107594164880975 no 3288 0.0155367025473868 4683 2239331 SGTC_2843 9000894 45.46 µM -2.16923585592442 0.010370586165324 no 3289 0.0150323911232033 4741 2242070 SGTC_1170 0310-0127 64.8 µM -2.1757557964917 0.0101817337027077 no 3290 0.0147867627938171 4721 774975 SGTC_1945 st075991 56.6 µM -2.17582150089569 0.0101798459205927 no 3291 0.0147843051593204 4708 1084980 SGTC_779 1360-0071 233 µM -2.18533161641484 0.00990980677273729 no 3292 0.0144322704223439 4732 7566 SGTC_582 0987-0078 156 µM -2.20712375821428 0.00931449257031536 no 3293 0.0136527071873833 4745 1625765 SGTC_696 1560-0013 611 µM -2.20904933623166 0.00926342647758035 no 3294 0.0135856047454367 4729 1650269 SGTC_2853 9015042 58.44 µM -2.21677547258764 0.00906098587706021 no 3295 0.0133192191951235 4665 6457456 SGTC_1179 1021-1431 9.29 µM -2.22835307199859 0.00876488238622092 no 3296 0.0129284899223973 4732 2840958 SGTC_1705 st027868 56.3335 µM -2.25920447723268 0.00801688152779622 no 3297 0.011935334229634 4702 292948 SGTC_1672 st016598 6.51 µM -2.26004079815876 0.00799741085710479 no 3298 0.0119093594312155 4706 4665860 YNL267W PIK1 SGTC_3320 9137005 35.139 µM -2.26196828712931 0.00795269458876223 no 3299 0.0118496813552796 4737 4908713 SGTC_2669 eugenol 100 µM -2.27153062663762 0.00773409125544706 no 3300 0.0115574375576947 4768 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_786 4544-0069 423 µM -2.28362555250432 0.00746517717166156 no 3301 0.011196773366752 4719 748821 YLR208W SEC13 SGTC_1518 st038567 90.8 µM -2.30421592579964 0.00702629161058953 no 3302 0.01060526282517 4709 77966 SGTC_2049 5262831 67.185 µM -2.32309560422372 0.00664404792015646 no 3303 0.0100870085389327 4709 763417 SGTC_1276 0871-0068 94.2 µM -2.34839358885236 0.00616072498325073 no 3304 0.00942729290880462 4747 3414906 SGTC_496 calpeptin 138 µM -2.34956536523063 0.00613911272260623 no 3305 0.00939767184918803 4729 73364 A calpain inhibitor. SGTC_601 0986-0029 62.9 µM -2.37419666990259 0.00570009566537991 no 3306 0.00879359000604892 4718 24747981 SGTC_2063 5246145 200 µM -2.39171588479997 0.00540503104266858 no 3307 0.0083849091544888 4735 711240 SGTC_252 miconazole 1.30953 nM -2.39556231668898 0.00534209547482787 no 3308 0.0082974465324397 4690 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2083 5306046 65.942 µM -2.4110806350808 0.00509475122610123 no 3309 0.00795266576213357 4765 539837 SGTC_988 1497-1057 103 µM -2.41984902102785 0.00495954779018914 no 3310 0.00776347613842317 4750 3533044 SGTC_1173 0443-0020 122 µM -2.41991405666543 0.00495855703587798 no 3311 0.00776208783349511 4753 5331295 SGTC_2801 7907800 81.82 µM -2.42204929934203 0.00492612647394625 no 3312 0.00771662833290311 4723 6620925 SGTC_2935 9038016 29.96 µM -2.43540931203759 0.00472746801908605 no 3313 0.00743747637777563 4721 6463195 SGTC_1511 0906-3109 28.5 µM -2.4733709746728 0.00420142046386358 no 3314 0.00669225624288396 4751 2882180 SGTC_249 wiskostatin 11.211 µM -2.48716064165845 0.00402370291487701 no 3315 0.00643836198680853 4752 2775510 A n-wasp and actin depolymerizer. SGTC_11 0438-0307 1.3 µM -2.49781234675016 0.00389106608240301 no 3316 0.00624811618928951 4748 4011476 SGTC_2043 5101342 149 µM -2.50708558734701 0.0037787985181413 no 3317 0.00608656160293214 4765 678451 SGTC_3233 9132340 49.47 µM -2.51206682901928 0.00371969933810932 no 3318 0.00600131783222979 4767 17682950 SGTC_1218 1348-1416 30.7 µM -2.52879387292488 0.00352726185472868 no 3319 0.005722761203668 4756 6787668 SGTC_2223 6903751 107.57 µM -2.53784580300124 0.00342689451757788 no 3320 0.00557685579230414 4749 5598863 SGTC_1519 esterone 74 µM -2.54010519134738 0.00340224612532146 no 3321 0.0055409566375788 4758 698 A steroid. SGTC_58 0957-0393 9 µM -2.55432695151113 0.00325072064312591 no 3322 0.00531966502680171 4341 6997992 SGTC_2237 6667747 47.222 µM -2.5738225827827 0.00305287042607586 no 3323 0.00502909176957714 4745 729940 YDL015C TSC13 SGTC_607 4491-0986 66.8 µM -2.57749875266251 0.00301680208687433 no 3324 0.00497591203486697 4764 698981 YDR232W HEM1 SGTC_991 3996-0057 64.7 µM -2.59669131301009 0.00283465691686952 no 3325 0.00470632359811254 4762 715343 SGTC_2730 imipramine 71.33 µM -2.6272849709139 0.00256474567284446 no 3326 0.00430346102406269 4756 3696 A tricyclic antidepressant. SGTC_599 1935-0052 86.5 µM -2.64590234395261 0.00241208647984633 no 3327 0.00407366666507473 4771 9557311 SGTC_1755 st041960 45.185 µM -2.67554676533267 0.00218591194941769 no 3328 0.00373037318327167 4778 2257073 SGTC_2476 5806916 10.51 µM -2.68813640091674 0.00209581385326808 no 3329 0.00359260197421779 4756 2870194 SGTC_1079 idarubicin 2.36 µM -2.69188453584715 0.00206964863132862 no 3330 0.00355247693332818 4792 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.71896699592035 0.00188922741537851 no 3331 0.00327430709517802 4783 688662 SGTC_2298 7976326 193.81 µM -2.78157278533071 0.0015256011429397 no 3332 0.00270480994004909 4774 2235818 SGTC_2693 st077581 40.7 µM -2.7894844796547 0.00148450453806557 no 3333 0.00263960133416794 4756 25238761 SGTC_2348 9022543 33.42 µM -2.79348430686293 0.00146411451778322 no 3334 0.00260717795061849 4773 3162678 YDL140C RPO21 SGTC_49 0717-0965 32.132 µM -2.80710739942056 0.00139657064884646 no 3335 0.00249942861611254 4788 5889349 YGL099W LSG1 SGTC_1165 k072-0275 30.3 µM -2.91985125480244 0.000937701012961465 yes 3336 0.00175099246070019 4794 6153523 YGL055W OLE1 SGTC_2691 st077356 60.2 µM -2.97027275346371 0.000781304134115959 yes 3337 0.0014876772355751 4772 2839272 SGTC_2200 6600604 21.907 µM -2.98900764163808 0.000729591415104904 yes 3338 0.00139942565823913 4797 2904777 SGTC_2025 5147754 141 µM -3.02357819947752 0.000642361910399817 yes 3339 0.00124902229499939 4794 315777 YLR208W SEC13 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -3.08266041697201 0.000515232757945148 yes 3340 0.00102579560534944 4785 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2201 6605497 169.863 µM -3.08763482011901 0.000505669299542206 yes 3341 0.00100878115494052 4789 670741 SGTC_3124 9127567 49.47 µM -3.12730468271838 0.00043508115213845 yes 3342 0.000882084981944537 4787 17592030 SGTC_1183 1254-0324 198 µM -3.13127416593257 0.000428545327942543 yes 3343 0.000870247957534116 4795 5799357 SGTC_360 0957-0399 1.01 µM -3.21227072495031 0.000313533523687044 yes 3344 0.000658451073853497 4792 6752301 YPR165W RHO1 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -3.2703478976112 0.000249525365169445 yes 3345 0.000537076453330298 4778 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_372 0155-0182 15.9 µM -3.29050271067162 0.000230322354037426 yes 3346 0.000500042691257071 4706 771486 SGTC_1944 st076371 56.9 µM -3.30450321718903 0.000217804520569362 yes 3347 0.000475724419462696 4795 24208455 SGTC_3128 9127691 49.47 µM -3.34874573665896 0.00018229713551241 yes 3348 0.000405891283203645 4794 41316314 SGTC_993 3909-8757 62.7 µM -3.7420713223559 3.41829688626642e-05 yes 3349 9.12548481387919e-05 4796 4288324 YLR208W SEC13 SGTC_2852 9023854 51.95 µM -3.7771565614662 2.92057479570911e-05 yes 3350 7.93145114492024e-05 4800 19798528 SGTC_2420 aureobasidin a 50 nM -3.92166523488475 1.50635253479964e-05 yes 3351 4.39695563179646e-05 4803 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3129 9127257 49.47 µM -4.07485135707743 7.28538296961323e-06 yes 3352 2.30218736249566e-05 4802 837894 SGTC_1070 indatraline 8.81 µM -4.1988355331938 3.97246201141049e-06 yes 3353 1.34145543643273e-05 4810 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_3131 9127911 49.47 µM -4.98389147742579 5.79530596135701e-08 yes 3354 3.11590201147993e-07 4806 45595681 SGTC_2859 9028643 45.46 µM -5.01064720224776 4.9586521061473e-08 yes 3355 2.71236424563355e-07 4804 17151580 SGTC_2812 7970281 58.44 µM -5.45543344344363 3.31019198083923e-09 yes 3356 2.44267641087127e-08 4809 2233435