SGTCid condition conc unit YKR073C|YKR073C.score YKR073C|YKR073C.strain.pval YKR073C|YKR073C.strain.significant YKR073C|YKR073C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1754 st042065 16.137 µM 11.5419008212778 6.34489434459059e-28 yes 1 4.05563546168359e-31 15 1126236 YIL048W NEO1
SGTC_1745 st081495 74 µM 9.49748268596287 1.75889721468268e-19 yes 2 1.07512658833657e-21 8 13842402 YBL026W LSM2
SGTC_1803 st050068 52.4 µM 8.24190940499559 4.25794444715556e-15 yes 3 8.47419401979378e-17 37 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_577 r071-0003 38.6 µM 7.67782523196757 2.5173311839033e-13 yes 4 8.09060188260887e-15 5 4568517 YMR134W ERG29
SGTC_403 arphamenine a 50 µM 6.73079530018367 1.26076426345021e-10 yes 5 8.43691081966336e-12 2 5487158 An arginine aminopeptidase inhibitor.
SGTC_1596 piperlongumine 63 µM 6.69771034302627 1.54431664214359e-10 yes 6 1.05855186619455e-11 2 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1202 1988-0068 29.6 µM 6.69111911719112 1.60782293235453e-10 yes 7 1.10735145359279e-11 5 2850480
SGTC_1750 st081859 2.357 µM 6.11078319926597 4.81021456730259e-09 yes 8 4.95716873006026e-10 106 5291695
SGTC_2651 TUB2.036 5 µM 5.6035266384812 7.36437153340986e-08 yes 9 1.05016909680449e-08 84 15992207 YFL037W TUB2
SGTC_1760 st045453 10.4495 µM 5.26039256002856 4.10526510724739e-07 yes 10 7.18740889224525e-08 101 3323419 YIL048W NEO1
SGTC_955 1216-0110 33 µM 5.22443396350964 4.88607652562753e-07 yes 11 8.73443275415786e-08 43 3619719
SGTC_788 1182-0090 188 µM 4.97760753465818 1.56619893800243e-06 yes 12 3.21875092794313e-07 52 5715185
SGTC_2902 5787006 60.46 µM 4.73120676444727 4.75299965617875e-06 yes 13 1.11594522714357e-06 15 591003
SGTC_682 0kpi-0099 17 µM 4.70287473248937 5.38196408792507e-06 yes 14 1.2826190860815e-06 44 1714895 YML126C ERG13
SGTC_2928 9011484 9.79 µM 4.70213079722126 5.39950496460478e-06 yes 15 1.28730239611358e-06 24 2994751
SGTC_2985 9022375 71.43 µM 4.6743948748163 6.09384977250831e-06 yes 16 1.47410801085179e-06 16 4939335
SGTC_2522 biochanin a 4.94 µM 4.63913507874096 7.10010336594162e-06 yes 17 1.74935164526011e-06 5 5280373 A possible chelator.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 4.55460625239843 1.01972545484433e-05 yes 18 2.62418959056163e-06 19 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_347 4534-1311 26.2 µM 4.49276045828835 1.32378437705352e-05 yes 19 3.51529256303558e-06 7 2862016
SGTC_923 1900-2434 73.3 µM 4.49120775842876 1.33242934979178e-05 yes 20 3.5410213015415e-06 21 5910570
SGTC_1262 0737-0114 49.6 µM 4.38518167153222 2.06799243356541e-05 yes 21 5.79445089929398e-06 14 765919
SGTC_25 0118-0223 35.662 µM 4.31845635015259 2.7135488928906e-05 yes 22 7.85621442035476e-06 9 5333628
SGTC_3334 9142812 21.919 µM 4.29555496584644 2.97612104275723e-05 yes 23 8.7128426348833e-06 21 45283678
SGTC_93 0109-0045 59.227 µM 4.2930254021697 3.00655569155552e-05 yes 24 8.81274160840703e-06 28 88733
SGTC_1257 0669-0121 16 µM 4.26454027675065 3.37025367794124e-05 yes 25 1.00157104678737e-05 16 4307855
SGTC_1908 st060353 56.5 µM 4.1740192611151 4.82230945801137e-05 yes 26 1.49636218960464e-05 31 4227716
SGTC_1785 bathophenanthroline 24 µM 4.16265511514519 5.041651927068e-05 yes 27 1.57284154921694e-05 41 72812 An iron chelator.
SGTC_843 0310-0051 143 µM 4.12562068445457 5.82363157715148e-05 yes 28 1.84868115859863e-05 8 2065037
SGTC_207 4185-0010 4.486 µM 4.08273764252465 6.87174800292748e-05 yes 29 2.22541302803916e-05 83 3761753
SGTC_1494 4358-1428 177 µM 4.01906949124298 8.7602645796752e-05 yes 30 2.92142187967503e-05 23 1564571
SGTC_873 0591-4978 488 µM 4.01109155791865 9.02868621679965e-05 yes 31 3.02193322581797e-05 20 3305145
SGTC_2119 5528445 120.635 µM 3.96523802238026 0.000107275832650965 yes 32 3.66613717576734e-05 17 791935
SGTC_3245 9134821 49.47 µM 3.95838675168824 0.000110058317903971 yes 33 3.77288519714618e-05 16 17014901
SGTC_72 0744-0168 198.391 µM 3.92644515505118 0.000123948399278747 yes 34 4.31052692313503e-05 31 677577
SGTC_95 0471-0001 561.058 µM 3.91760529701373 0.000128073565075847 yes 35 4.47164921281521e-05 27 4015405
SGTC_313 3474-0040 5.03 µM 3.91700684103974 0.000128357440030895 yes 36 4.48276027726745e-05 72 1043375 YIL048W NEO1
SGTC_1204 4049-0315 18.3 µM 3.8855913101868 0.00014411551156856 yes 37 5.10405573335425e-05 28 588402
SGTC_1047 2043-3044 82 µM 3.87554649657809 0.000149524831824289 yes 38 5.31928309617711e-05 38 669592
SGTC_1124 fisetin 1.16336 µM 3.86397260476444 0.000155993194133484 yes 39 5.57788693137104e-05 37 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2342 7990637 118.86 µM 3.85559718637274 0.00016083639190418 yes 40 5.7723726756327e-05 38 2033102 YER133W GLC7
SGTC_1818 st052136 56.3 µM 3.83728633402111 0.000171919304237061 yes 41 6.22006957718175e-05 57 674169
SGTC_1093 fluphenazine 7.97 µM 3.8280941548511 0.00017774859553061 yes 42 6.45696787000169e-05 15 6602611 An atypical antipsychotic.
SGTC_2332 7982454 138.89 µM 3.80825595345136 0.000190964778097219 yes 43 6.99751868561338e-05 54 2981748
SGTC_1075 aripiprazole 15.2 µM 3.7680488570967 0.000220614956868712 yes 44 8.22642530352204e-05 36 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3182 9108849 49.47 µM 3.74393270427348 0.000240405897544014 yes 45 9.05810968430433e-05 15 17133045
SGTC_3316 9136639 10.545 µM 3.6756296499217 0.000305811274361213 yes 46 0.000118631754555377 18 4903665
SGTC_1721 st082152 9.2685 µM 3.6522492148631 0.00033176643704344 yes 47 0.00012997671003145 27 5296051
SGTC_1545 lovastatin 49.4 µM 3.65080297593665 0.000333437369663555 yes 48 0.000130710863454284 33 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1227 3909-8010 46.6 µM 3.57624352731237 0.000430977096752972 yes 49 0.000174283480196326 32 15982272
SGTC_2582 agaric acid 100 µM 3.56446865649242 0.000448607669448207 yes 50 0.000182297007020215 361 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1447 4239-0816 81.9 µM 3.56364229085766 0.000449869758507821 yes 51 0.000182872144266615 42 1341554
SGTC_398 bronopol 33.3 µM 3.5586672785953 0.000457537787770021 yes 52 0.000186370681430631 29 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_517 1365-0151 113 µM 3.54189987596468 0.000484282542933777 yes 53 0.000198628115582815 41 768657
SGTC_956 1185-0240 191 µM 3.53824822187149 0.000490295877555688 yes 54 0.000201395606928149 34 1416193
SGTC_1626 st003712 1.76 µM 3.53335832903111 0.000498456582470842 yes 55 0.000205157966073348 36 24207035
SGTC_1066 ketoconazole 628 nM 3.52217689719931 0.000517591967717023 yes 56 0.00021400921641626 35 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2877 9040724 71.43 µM 3.49022515814186 0.000576083336229412 yes 57 0.000241306873082418 25 6463895
SGTC_2623 humulene 100 µM 3.4754274204645 0.000605191730019981 yes 58 0.000255019994206059 34 6187145 An anti-inflammatory.
SGTC_167 3672-0051 66.205 µM 3.4556257588143 0.000646270472292775 yes 59 0.000274508506839544 57 3237971
SGTC_2154 5570129 200 µM 3.45233859186761 0.000653333750167359 yes 60 0.000277874931724832 32 673366
SGTC_2532 xanthone 78.9 µM 3.44564554696467 0.000667936096899646 yes 61 0.000284848540493749 45 7020 An insecticide.
SGTC_1800 st050079 29.0735 µM 3.31262694667723 0.00102831750802769 no 62 0.000462120853095822 182 3645560
SGTC_2729 fluphenazine 10.66 µM 3.2929646771767 0.00109465956784353 no 63 0.000495684643056035 36 3372 An atypical antipsychotic.
SGTC_954 1189-0853 2.85 µM 3.28685597676638 0.00111605596524446 no 64 0.000506563172726507 66 2828194
SGTC_418 lividomycin a 100 µM 3.27163388609733 0.00117105083216066 no 65 0.000534639729658916 30 72394 An antibiotic.
SGTC_2698 st077697 67.5 µM 3.27071556578322 0.0011744466403584 no 66 0.000536378739717791 32 3154499
SGTC_53 0973-0023 39.979 µM 3.27049836736372 0.00117525112432322 no 67 0.000536790809665653 27 674768
SGTC_1145 3546-0597 10.2 µM 3.26736730551261 0.00118690450787225 no 68 0.000542763705978503 43 875334
SGTC_550 4123-0385 25.7 µM 3.25531948369403 0.00123273830674931 no 69 0.000566324369877406 58 5731123
SGTC_2038 4100038 30.985 µM 3.23857902451875 0.00129911505867977 no 70 0.000600633686353181 82 3596803
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 3.2385786585056 0.00129911654499629 no 71 0.000600634457045758 52 6312947
SGTC_1394 3474-0001 65.7 µM 3.23697246613948 0.00130565401051564 no 72 0.000604025334951719 65 5017666 YIL048W NEO1
SGTC_3116 9124943 49.47 µM 3.23215193501673 0.00132545536265872 no 73 0.00061430855768396 36 41905195 YPL160W CDC60
SGTC_2390 9097792 176.6 µM 3.21810105788804 0.00138474863492632 no 74 0.000645211717717209 39 4497149
SGTC_2482 5981709 142.65 µM 3.19868396602065 0.00147067696851168 no 75 0.00069028209395116 72 877755
SGTC_116 0155-0182 31.788 µM 3.17126380911213 0.00160032090911162 no 76 0.000758886190177635 144 771486
SGTC_514 4466-0038 2.65 nM 3.1682012962238 0.00161542932106937 no 77 0.000766926389208092 212 5722064
SGTC_671 0560-0003 407 µM 3.16226028973 0.00164510950275084 no 78 0.000782747822924325 36 3238678
SGTC_1703 st026983 48.3 µM 3.15460538562533 0.0016840841978497 no 79 0.000803576612984559 39 1104023
SGTC_1852 st056254 31.4 µM 3.12060269154518 0.00186757121187455 no 80 0.000902406787831829 38 442583
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 3.10582127888686 0.00195285935023493 no 81 0.00094875681748727 73 4174840
SGTC_528 3492-0019 172 µM 3.10072559735095 0.0019830714522478 no 82 0.000965235482101433 298 2869262
SGTC_221 trifluoperazine 10.304 µM 3.09782213130116 0.00200047520142485 no 83 0.000974741981751472 268 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_614 0462-0418 107 µM 3.08162566791878 0.00210012845335614 no 84 0.00102936777513626 70 5188303
SGTC_2309 7664088 163.95 µM 3.08054546437258 0.00210693223671212 no 85 0.00103310903537848 97 704922
SGTC_673 1082-0474 110 µM 3.06750638266648 0.00219065227232252 no 86 0.00107926425453914 117 3098046
SGTC_2029 5175081 200 µM 3.06570794098137 0.00220243319396799 no 87 0.00108577659360589 61 1380876
SGTC_2737 bleomycin 30.5 nM 3.06271622636214 0.00222215807041071 no 88 0.00109668974598236 137 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1014 4130-3005 69.3 µM 3.05998605204225 0.00224029812672781 no 89 0.00110673649807828 63 743608
SGTC_1757 st041620 31.8375 µM 3.03345721937526 0.00242367651023858 no 90 0.0012088449401694 70 5289815
SGTC_1186 1319-0216 26 µM 3.02663963370301 0.00247294563318471 no 91 0.00123644288364924 60 4565136
SGTC_555 4296-0685 37 µM 3.02059413146745 0.00251739091680458 no 92 0.00126139638587588 41 2908540 YHR072W ERG7
SGTC_1284 0929-0043 16 µM 3.01485512493562 0.00256024980455568 no 93 0.0012855101552891 68 1239883
SGTC_2093 5331342 194.4 µM 3.00818043243192 0.00261092518241607 no 94 0.0013140852406071 57 33839
SGTC_1440 4100-1550 40 µM 3.00328777072503 0.00264864478984355 no 95 0.00133539877922212 18 742806
SGTC_552 k242-0005 476 µM 2.98940065072652 0.00275840251162169 no 96 0.00139762667157592 56 4088318
SGTC_337 1315-0038 354 µM 2.98289653900707 0.00281120603176304 no 97 0.00142767249111699 61 1626437
SGTC_855 0428-0020 25 µM 2.97870565989817 0.00284571095751435 no 98 0.00144734349056909 54 6812414
SGTC_86 0417-1630 471.922 µM 2.97595403003775 0.00286857331936434 no 99 0.00146039320350935 228 3634867
SGTC_1472 k841-0093 193 µM 2.93080561299998 0.00326810995353216 no 100 0.00169042131141961 64 X1472
SGTC_2866 9034245 58.44 µM 2.91017841484009 0.00346677546114197 no 101 0.00180611243631744 43 6462273
SGTC_2220 6782180 200 µM 2.90003367094041 0.00356840654192745 no 102 0.00186561288280478 29 833803
SGTC_2977 9011197 71.43 µM 2.89958084297387 0.00357300474873048 no 103 0.0018683098631457 54 2704722
SGTC_3000 9075062 71.4286 µM 2.89791362092136 0.00358998030454215 no 104 0.00187827017762725 69 17057871
SGTC_331 k048-0133 24.5 µM 2.88986745863767 0.00367292786714791 no 105 0.00192702141862779 51 6813582
SGTC_187 1488-2104 32.728 µM 2.88912800183806 0.00368063650337194 no 106 0.00193155893101603 81 2852859
SGTC_1154 4088-0362 150 µM 2.88593876619089 0.00371404996960032 no 107 0.00195124038190048 91 6618304
SGTC_1193 1488-0126 41.5 µM 2.88087603744328 0.00376765092045593 no 108 0.00198285789093792 64 1384710
SGTC_2531 methyl deoxycholate 70.07 µM 2.88076340980963 0.00376885119692867 no 109 0.00198356652744387 81 16667744 Haematoxylin.
SGTC_3249 9135183 49.47 µM 2.87853953474754 0.00379262143420532 no 110 0.00199760600441722 67 4902779
SGTC_1320 1313-0481 95.3 µM 2.87451375524562 0.00383599371003364 no 111 0.00202325071782949 63 6813365 YLR208W SEC13
SGTC_272 doxorubicin 8.13 µM 2.87011549493561 0.00388388665412967 no 112 0.00205160947891763 97 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2514 salinomycin 42.74 µM 2.86638685395161 0.00392490695878124 no 113 0.00207593272086877 116 23682228 A polyether potassium ionophore.
SGTC_2088 5278280 127.392 µM 2.8662961587528 0.00392590955073118 no 114 0.00207652760363447 88 791502
SGTC_2997 9067075 71.4286 µM 2.86101815059632 0.00398465203843356 no 115 0.00211141437583335 116 27209819
SGTC_2265 7929201 200 µM 2.85090405840035 0.00409942213090401 no 116 0.00217975607102372 78 1265108
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 2.84855540171951 0.00412649324850979 no 117 0.00219591030457659 127 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2700 st077718 96.8 µM 2.83184624499209 0.00432374825022396 no 118 0.00231400484213333 53 904970
SGTC_2767 sibutramine 71.45 µM 2.83087312718783 0.00433549162249432 no 119 0.0023210565374314 75 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1310 1188-0297 994 nM 2.81346453312117 0.00455044649360519 no 120 0.00245053961943715 89 1588352
SGTC_1597 7-benzyloxygramine 47.5 µM 2.79100456019048 0.0048418061795543 no 121 0.00262723659908358 256 260807
SGTC_961 1252-1571 372 µM 2.78694392771891 0.00489622255003703 no 122 0.00266038423762881 85 6813498
SGTC_2976 9009005 19.48 µM 2.78287794774213 0.00495125600465178 no 123 0.00269395352976258 78 2993148
SGTC_877 0771-0151 33.1 µM 2.76846512991945 0.00515080053639365 no 124 0.0028160506096056 67 6166523
SGTC_1987 st072290 61.9 µM 2.75490491630948 0.00534504324411177 no 125 0.00293545971643007 78 54697379
SGTC_1953 st076800 12.1 µM 2.7547752148219 0.00534693217751914 no 126 0.00293662355672783 124 297591
SGTC_2959 9079155 11 µM 2.74097685793337 0.00555130955082769 no 127 0.00306284109045425 85 16189457
SGTC_2389 9091542 195.52 µM 2.73572746516779 0.00563086601479157 no 128 0.00311212759652813 113 3626624 YOL127W RPL25
SGTC_3111 9122088 49.47 µM 2.73519791599184 0.00563894747371513 no 129 0.0031171389674257 32 16876704
SGTC_531 3788-1495 174 µM 2.72258511444269 0.00583450011309312 no 130 0.00323866728728549 96 2896655
SGTC_2192 5915882 198.485 µM 2.7220386677537 0.00584310673172022 no 131 0.00324402751942272 61 2876149
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.71588871285842 0.005940748921439 no 132 0.00330490661108289 120 688664
SGTC_1338 1486-1223 76 µM 2.71094412036562 0.00602030014114136 no 133 0.00335459659868968 83 3444526
SGTC_3250 9135583 49.47 µM 2.7067548816044 0.00608843623305518 no 134 0.00339722017813684 61 7699353
SGTC_2741 miltefosine 3.04 µM 2.70479786274317 0.00612049979538885 no 135 0.00341729822841904 81 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2890 9046729 58.44 µM 2.70416806765272 0.00613085005555385 no 136 0.00342378225711715 76 903329
SGTC_2970 9090938 41.86 µM 2.69610179441848 0.00626479160072373 no 137 0.00350781117900874 146 17217104
SGTC_797 k781-0471 270 µM 2.69596702586349 0.00626705128699543 no 138 0.00350923070016503 82 23738129
SGTC_2892 9047358 58.44 µM 2.69577623279378 0.00627025157947111 no 139 0.0035112412113115 45 6466771
SGTC_3311 9131146 2.8755 µM 2.68512244803361 0.00645126639474364 no 140 0.00362516191539189 207 4900406 YPR165W RHO1
SGTC_208 k072-0098 12.366 µM 2.68378792080178 0.00647426365465516 no 141 0.00363966330505145 140 5948901
SGTC_3253 9135987 49.47 µM 2.66878092198769 0.00673790830490059 no 142 0.00380635435513281 62 4182430
SGTC_2736 butenafine 14.65 µM 2.66296656828023 0.00684257815249927 no 143 0.00387275545183642 107 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1037 k284-1091 78.7 µM 2.66288268663092 0.00684409863871182 no 144 0.00387372094578133 71 3334711
SGTC_938 3126-1755 342 µM 2.65108191052194 0.00706100306928182 no 145 0.00401171902125125 73 1777771
SGTC_354 2783-3500 4.88 µM 2.65067360520033 0.00706861531082672 no 146 0.00401657155163215 140 6740761
SGTC_1669 st015249 58.4 µM 2.6484864221622 0.00710951548628575 no 147 0.00404265485138197 55 722793
SGTC_161 4065-0411 162.148 µM 2.62641551235945 0.0075340676336768 no 148 0.00431447055364433 171 1906281 YLR208W SEC13
SGTC_298 1391-0729 10 µM 2.61316558839788 0.00779953180536229 no 149 0.00448539133545832 77 3237558
SGTC_2176 5809774 33.9695 µM 2.61282525621845 0.00780645748192131 no 150 0.00448986009604002 71 2870539
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.57056862227514 0.00870954163443245 no 151 0.00507658546559487 84 229346 A bile salt which induces apoptosis.
SGTC_1841 st054148 70 µM 2.56698745009219 0.00879012903791648 no 152 0.00512931625953442 93 675442
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.54216470631961 0.00936690144252667 no 153 0.00550841225417483 66 61125 An anti-inflammatory.
SGTC_1091 telmisartan 47.6 µM 2.53421369025386 0.00955852069263319 no 154 0.00563499910064156 91 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1144 3486-0183 12.5 µM 2.52190157633268 0.00986200446597757 no 155 0.00583611809546867 117 6744069
SGTC_1419 3993-2473 62.6 µM 2.52168518428042 0.00986741275521905 no 156 0.00583970910141091 98 704026
SGTC_2475 5812728 15.03 µM 2.51283210801945 0.0100909097527797 no 157 0.00598831586197614 123 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2688 kanamycin b 96.69 µM 2.51206905142283 0.0101103783875263 no 158 0.00600128003773811 643 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2452 5863136 48.41 µM 2.49475405899664 0.0105610482995744 no 159 0.00630222294603793 120 2184096
SGTC_2335 9018011 154.17 µM 2.48532613044425 0.0108137188164111 no 160 0.00647163985185821 136 6458208
SGTC_1583 clindamycin 39.6 µM 2.4792575808995 0.0109791268407086 no 161 0.00658280955153343 112 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2906 7926292 26.41 µM 2.47551759431524 0.0110821588090791 no 162 0.00665216031354783 140 2966319
SGTC_2201 6605497 169.863 µM 2.47444194800814 0.0111119467986377 no 163 0.00667222529854231 78 670741
SGTC_1664 st014217 9.02 µM 2.47328695870112 0.0111440095424408 no 164 0.00669382988114068 97 3982782
SGTC_2517 totarol 10 µM 2.47169189623254 0.011188421055639 no 165 0.00672376786999142 111 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3237 9133362 49.47 µM 2.46401043324248 0.0114044583752084 no 166 0.00686960560465633 133 43845137
SGTC_120 rhodamine 6G 52.259 µM 2.45385505347339 0.0116956304088476 no 167 0.00706669687130176 163 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2778 tioconazole 65.09 nM 2.42958911316771 0.012417633275574 no 168 0.00755797422742016 191 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_90 0870-0863 4.608 µM 2.42894023615935 0.0124374583316771 no 169 0.00757151413324687 165 1738164
SGTC_69 0096-0274 206.684 µM 2.41319451546897 0.0129270087523057 no 170 0.00790668886165207 188 6741392
SGTC_1304 1165-0502 251 µM 2.41303772267331 0.0129319662135305 no 171 0.00791009106045907 177 767425
SGTC_1991 st073000 8.92 µM 2.41302034590219 0.0129325157319766 no 172 0.00791046819292979 205 4301969 YIL048W NEO1
SGTC_1107 amlodipine 47 µM 2.40742216190258 0.01311060563716 no 173 0.00803279326650456 150 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3215 9129942 49.47 µM 2.40305460779404 0.0132510147226612 no 174 0.00812937965804484 84 17682944
SGTC_439 amiodarone 34.4 µM 2.39804134118907 0.0134137819021079 no 175 0.00824150239801891 227 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1789 tunicamycin 25 nM 2.3874988767412 0.0137617075455362 no 176 0.00848172729750257 162 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2533 agelasine 13.65 µM 2.38187941768798 0.0139503232849321 no 177 0.00861226827135703 174 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_3356 9151811 4.48 µM 2.38169676384551 0.0139564912311091 no 178 0.00861654076226916 124 1859254 YPR165W RHO1
SGTC_2753 fluvastatin 17.09 µM 2.36979674413954 0.0143634357509042 no 179 0.00889893324458896 150 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3037 9091026 49.47 µM 2.36245482131931 0.0146195706044413 no 180 0.00907717703764437 293 25236398 YIL048W NEO1
SGTC_841 0251-0215 91.2 µM 2.36178095964039 0.0146432750738276 no 181 0.00909369231668459 191 3888614
SGTC_796 1234-0020 70.7 µM 2.35899272800687 0.0147417086786363 no 182 0.0091623074266322 136 46495034
SGTC_1511 0906-3109 28.5 µM 2.35615629928293 0.0148424272651793 no 183 0.00923257323052623 217 2882180
SGTC_1027 k015-0025 8.67 µM 2.34714400514244 0.0151663807658282 no 184 0.00945897077915927 141 3598955
SGTC_622 1348-1566 26.3 µM 2.34610433425299 0.0152041404426652 no 185 0.00948539810811595 146 7340407
SGTC_252 miconazole 1.30953 nM 2.34505505863818 0.0152423308064496 no 186 0.00951213501607742 164 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1127 asiatic acid 681.4 nM 2.33905738523705 0.0154622126868372 no 187 0.00966623188483467 157 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1006 4099-6547 255 µM 2.33639725408 0.0155606046161388 no 188 0.00973527346819404 154 3146833
SGTC_1399 3562-5772 25 µM 2.3292388859204 0.0158280481337598 no 189 0.00992320697261386 114 23847490
SGTC_2769 toremifene 3.73 µM 2.32881940758132 0.01584384177862 no 190 0.0099343174103771 141 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1113 artemisinin 1.17947 µM 2.32806805779681 0.0158721643917475 no 191 0.00995424505140463 117 2240 An anti-malaria and mitochondrial poison.
SGTC_884 0851-0618 334 µM 2.32736111489541 0.0158988526885185 no 192 0.00997302676775137 147 9642473
SGTC_97 0535-0701 19.132 µM 2.32129935801135 0.0161292778697502 no 193 0.0101353464332956 132 2832013 YGL099W LSG1
SGTC_1977 st070720 65.3 µM 2.31188959425132 0.0164926378064152 no 194 0.0103918841558072 112 682188
SGTC_1668 st014914 51.6 µM 2.28092291013132 0.017738300957034 no 195 0.0112765045003465 106 2839556
SGTC_445 e6 berbamine 66 µM 2.27896623599859 0.0178196371007853 no 196 0.0113345362314089 317 6610268 A calcium/calmodulin antagonist.
SGTC_2844 9010103 25.97 µM 2.27438002207027 0.0180115270490468 no 197 0.0114715737813126 184 2480525
SGTC_2920 7982904 15.77 µM 2.27190706645511 0.0181157261712249 no 198 0.0115460620065079 151 6456808
SGTC_199 4063-0024 41.6 µM 2.25729256587487 0.0187420620808762 no 199 0.0119948997941322 103 306215
SGTC_2662 daunorubicin 22.37 µM 2.25642574241861 0.0187797836492377 no 200 0.0120219904889474 140 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_786 4544-0069 423 µM 2.25520566721848 0.0188329871254934 no 201 0.0120602111887548 179 748821 YLR208W SEC13
SGTC_1327 1436-0082 2.18 µM 2.25465725462821 0.0188569433440397 no 202 0.0120774253345688 152 15992205
SGTC_329 k048-0121 21.3 µM 2.24686877403631 0.0191999746046001 no 203 0.0123242074303615 149 6832902
SGTC_1022 4477-0945 21.3 µM 2.24159757820604 0.0194351338852251 no 204 0.0124936963229485 166 4648966
SGTC_1865 st057639 52.2 µM 2.23783256934085 0.0196045930587658 no 205 0.0126159878215972 146 688818
SGTC_1612 st002233 45.4 µM 2.23368875623398 0.0197925505937709 no 206 0.0127517796636764 147 1035021
SGTC_2238 6671620 73.2395 µM 2.22611365466419 0.0201401012396467 no 207 0.0130032847744253 157 729941
SGTC_2787 5284540 71.43 µM 2.22497642962675 0.0201927220811503 no 208 0.0130414102499941 179 736958
SGTC_2865 9030313 51.95 µM 2.22345904487216 0.0202631149032876 no 209 0.0130924310376059 125 42562754
SGTC_2740 felodipine 17.08 µM 2.22181192250184 0.0203397617416432 no 210 0.0131480093295224 115 3333 L-type calcium channel blocker
SGTC_1594 piperine 70.1 µM 2.21566973524026 0.0206277513657789 no 211 0.0133570645415724 168 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_729 4092-0585 94.1 µM 2.21490131523076 0.0206640223000166 no 212 0.0133834194109703 166 2169061
SGTC_328 k915-0120 63.5 µM 2.2121289281914 0.0207953337451208 no 213 0.0134788789128832 154 6624543
SGTC_1179 1021-1431 9.29 µM 2.20750310782526 0.0210160040314954 no 214 0.0136394650571608 226 2840958
SGTC_1425 4048-4433 7.33 µM 2.18789058032136 0.0219737369910581 no 215 0.0143387868071585 194 23734946
SGTC_2082 5219693 150 µM 2.18764804189425 0.0219858077177501 no 216 0.0143476247519226 196 2834649
SGTC_2978 9011784 42.97 µM 2.17860305110117 0.0224399753811642 no 217 0.0146805846673075 229 2994934
SGTC_1627 st003713 25.6 µM 2.17739270580535 0.0225013453734434 no 218 0.0147256397266303 290 16195070 YER133W GLC7
SGTC_77 0828-0286 12.516 µM 2.17002377162243 0.0228780452143413 no 219 0.0150025225787935 212 745345
SGTC_1356 1502-0781 85.8 µM 2.16657796115335 0.0230560099548212 no 220 0.0151335246835327 176 567702
SGTC_2744 captopril 92.04 µM 2.16595590074588 0.0230882612319805 no 221 0.0151572784836925 109 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1676 st018489 23.4 µM 2.16551835981171 0.0231109686828218 no 222 0.0151740054656676 213 3696235
SGTC_1522 st012842 45.6 µM 2.16047779869955 0.0233739220675571 no 223 0.0153678502391815 182 3491067 YOR116C RPO31
SGTC_2619 obliquin 87.91 µM 2.15909536826119 0.0234464783761844 no 224 0.0154213844621913 348 6708593 A bioactive alkalod. YER133W GLC7
SGTC_813 k007-0158 173 µM 2.15827080188948 0.0234898455672019 no 225 0.0154533917262121 219 6523916
SGTC_844 0330-0132 15.3 µM 2.15125714020547 0.0238614569263601 no 226 0.0157279545890694 158 2828079
SGTC_2186 6124449 200 µM 2.14954126169542 0.0239531195284534 no 227 0.0157957594595851 174 3834182 YLR033W RSC58
SGTC_2543 pimpinellin 60.67 µM 2.14875167314738 0.0239953988311901 no 228 0.0158270450704826 178 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1707 st032323 6.317 µM 2.14129660597598 0.0243976876970231 no 229 0.016125063331684 249 3132057 YMR211W DML1
SGTC_509 pifithrin 175 µM 2.12850070270947 0.0251013747331244 no 230 0.0166477958771841 125 4817 A p53 inhibitor.
SGTC_2170 morpholine 200 µM 2.11513698198204 0.0258543693380233 no 231 0.0172091370278376 153 121171 Reacts with secondary amines.
SGTC_1190 1486-1332 13 µM 2.09177302603369 0.027216233043892 no 232 0.0182294121993547 194 4150046
SGTC_1461 k072-0203 53.8 µM 2.08995625831241 0.0273245930791239 no 233 0.0183108645894047 183 5418714
SGTC_3331 9141060 1.957 µM 2.08536197346887 0.0276002229311317 no 234 0.0185182279278905 185 4906567 YPR165W RHO1
SGTC_449 xestospongin c 11.1929 µM 2.07446139632492 0.0282634757647112 no 235 0.019018240199298 258 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_345 1362-0200 395 µM 2.07331014734617 0.0283342924161309 no 236 0.0190717124719983 196 1419823
SGTC_2435 5706476 10.6 µM 2.06305325566272 0.0289717651082533 no 237 0.0195537843251146 232 5725375
SGTC_1575 cyproterone acetate 48 µM 2.06027637577043 0.0291463859826444 no 238 0.0196860635251321 210 9880 An androgen receptor antagonist and liver toxin.
SGTC_1293 1000-1278 195 µM 2.06009507278328 0.029157817353305 no 239 0.0196947264157451 211 678847
SGTC_2328 6201408 200 µM 2.05600999485043 0.0294163754234657 no 240 0.0198907764072732 193 2890418
SGTC_3341 9147222 25.867 µM 2.04513216619536 0.0301141658461493 no 241 0.0204209149202671 187 1939759
SGTC_2502 avocadyne acetate 18.59 µM 2.04375923234493 0.030203204178554 no 242 0.0204886692139842 242 3952079
SGTC_520 3584-0023 682 µM 2.03356774960678 0.0308709925440992 no 243 0.0209975981214448 207 1340790
SGTC_1837 st055472 66.5 µM 2.03352610935618 0.0308737458533163 no 244 0.020999699244882 219 676091
SGTC_121 0557-0495 61.343 µM 2.03106375393284 0.0310369218455862 no 245 0.0211242638593502 337 3104427
SGTC_60 0986-0278 202 µM 2.02588624107738 0.031382354852632 no 246 0.0213882217576276 141 3110598
SGTC_2910 7948405 25.97 µM 2.01796824414049 0.0319167705731469 no 247 0.021797284352313 183 2971328
SGTC_1334 1486-0610 236 µM 2.01770314675031 0.0319347922465352 no 248 0.0218110934592498 212 3742339
SGTC_3261 9137475 49.47 µM 2.01764192847859 0.0319389551403559 no 249 0.0218142834114587 64 17027690
SGTC_1555 citronellol 128 µM 2.01637283669733 0.0320253554421669 no 250 0.0218805018579978 144 8842 A terpine precursor.
SGTC_2341 7987486 176.74 µM 2.00590328096265 0.0327455152614403 no 251 0.0224332840717322 238 1258686
SGTC_1590 st077108 57.8 µM 2.00535279521862 0.0327837475611452 no 252 0.022462672195839 159 5489485
SGTC_1622 st003707 19.4 µM 2.00489552570882 0.0328155337878175 no 253 0.0224871085756493 274 10140899
SGTC_122 0236-0016 402.397 µM 2.00153586140189 0.0330498543891461 no 254 0.0226673365665684 277 6808838
SGTC_1106 tegaserod maleate 11.7 µM 2.00054318207694 0.0331193523216871 no 255 0.0227208209483866 246 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2436 5633522 8.09 µM 1.998957676663 0.033230603974329 no 256 0.0228064666809733 233 5724242
SGTC_447 ml7 120 µM 1.99681326867948 0.0333815621921619 no 257 0.0229227358183989 212 4216 Selective myosin light chain kinase inhibitor.
SGTC_2867 9039098 71.43 µM 1.99422882194494 0.033564247382327 no 258 0.0230635268731963 241 6463460
SGTC_3028 9087778 49.47 µM 1.99411121405742 0.0335725801960348 no 259 0.0230699509988862 193 17217395
SGTC_1325 1431-0015 227 µM 1.97775113684305 0.03474843510896 no 260 0.0239783941489145 200 1103340
SGTC_1679 SEC14.276 6.7 µM 1.97532699506466 0.0349255093711302 no 261 0.0241155258346349 276 1005053 YMR079W SEC14
SGTC_3308 9128332 17.569 µM 1.9697036885769 0.0353391233142281 no 262 0.0244361700040113 331 17332805 YDL196W YDL196W
SGTC_3244 9134489 49.47 µM 1.96836512020889 0.0354381694249642 no 263 0.0245130210728875 225 16584271
SGTC_1049 3226-0134 66 µM 1.96553166310605 0.0356485793902295 no 264 0.0246763673382485 265 5702385
SGTC_583 1488-1091 88.9 µM 1.96107818054447 0.0359813596113766 no 265 0.0249349518016709 279 4303273
SGTC_1277 0873-0036 22 µM 1.96091434880869 0.0359936500690945 no 266 0.0249445076006651 273 5965735
SGTC_2794 7785382 27.27 µM 1.95338106458039 0.0365625126792025 no 267 0.0253872291275401 307 2205081
SGTC_913 3487-1245 167 µM 1.95073950198234 0.0367637191465322 no 268 0.0255440208825047 259 4016153
SGTC_613 3914-0030 117 µM 1.95068043980014 0.0367682282115719 no 269 0.0255475358054258 57 1145395
SGTC_1024 4507-0395 26 µM 1.94310982244568 0.0373499576036943 no 270 0.0260014452426133 229 4201836
SGTC_2348 9022543 33.42 µM 1.9402634769287 0.0375706075512114 no 271 0.0261738388116268 243 3162678 YDL140C RPO21
SGTC_2269 7935389 174.42 µM 1.93964021765554 0.0376190646511289 no 272 0.0262117148063812 236 97605
SGTC_1480 1070-0044 41.2 µM 1.93744158849634 0.0377904110875476 no 273 0.0263456935210413 241 3124987
SGTC_422 cantharidin 155 µM 1.93590783328332 0.0379103184470214 no 274 0.0264394950975878 308 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_677 0929-0063 136 µM 1.92971488454869 0.0383976378273692 no 275 0.0268210873311124 163 1539583
SGTC_1632 st005650 90 µM 1.91638706100572 0.0394637224460744 no 276 0.0276579232687519 248 2759605
SGTC_349 k015-0014 24 µM 1.91445421959033 0.0396203096420172 no 277 0.0277810716774426 236 2196908
SGTC_2585 alliin 100 µM 1.90343957395367 0.0405223198315843 no 278 0.0284916056725545 275 87310 A garlic compound which reacts with lipids.
SGTC_1615 st002656 86.5 µM 1.90232616153148 0.0406144197012781 no 279 0.0285642637691698 223 1584458
SGTC_1971 st069429 63.5 µM 1.89802891598982 0.0409714761487512 no 280 0.0288461365002494 204 1246522 YGL099W LSG1
SGTC_722 3534-0461 190 µM 1.89712228379169 0.0410471321679758 no 281 0.0289059004020784 268 658262
SGTC_2953 9074162 66.49 µM 1.89514120930421 0.0412128417822823 no 282 0.0290368481978229 215 16451992
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.88993001140812 0.0416513302147379 no 283 0.0293836605634364 264 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_778 3456-2434 196 µM 1.88961432450301 0.0416780141556648 no 284 0.0294047799828773 335 5539063
SGTC_2933 9026794 32.47 µM 1.88711799027501 0.0418895088087265 no 285 0.0295722287416746 289 17586027
SGTC_1720 st037298 9.481 µM 1.88316176981515 0.0422264671225103 no 286 0.0298392241251047 267 597396
SGTC_875 0709-0210 25.7 µM 1.86191175186087 0.0440740737405677 no 287 0.0313077651430732 298 6251364
SGTC_3330 9141424 71.43 µM 1.86033105615459 0.0442140739787595 no 288 0.0314193511473758 283 27261020
SGTC_2804 7954240 19.48 µM 1.85416403644588 0.0447637101356417 no 289 0.0318578477635362 296 828705
SGTC_2050 5263056 171 µM 1.84686751102042 0.0454211050850758 no 290 0.032383172215339 324 763468 YGL055W OLE1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.84634874929669 0.0454681380555076 no 291 0.032420791822138 272 6708514
SGTC_2971 9092186 9.93 µM 1.84462189050104 0.0456249840820802 no 292 0.032546280187092 252 25236400
SGTC_1755 st041960 45.185 µM 1.83521134139542 0.0464873786033904 no 293 0.0332371906752295 259 2257073
SGTC_1712 st032288 53.4 µM 1.83361415214402 0.0466350374937098 no 294 0.0333556449833741 495 2883011
SGTC_336 4111-0029 111 µM 1.82512750908853 0.0474259444431542 no 295 0.0339908949007545 224 3131175
SGTC_973 1325-0077 65.9 µM 1.8213639218531 0.047780112259769 no 296 0.0342757777961794 279 2835149
SGTC_2408 sulbentine 18.36 µM 1.81993990458316 0.0479146686596534 no 297 0.034384078557908 290 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_802 4112-3352 742 µM 1.8156362887111 0.0483231647571982 no 298 0.0347130915737253 309 704594
SGTC_3291 9121177 71.43 µM 1.81342064222672 0.048534555995138 no 299 0.0348834840851093 233 17015612
SGTC_3254 9136651 49.47 µM 1.81270643027559 0.0486028551714261 no 300 0.0349385560945127 293 16454030
SGTC_2396 5342950 42.78 µM 1.81207302422414 0.0486634912546042 no 301 0.0349874569519702 347 1886677
SGTC_826 1683-5028 118 µM 1.80820344069281 0.0490352415246657 no 302 0.0352874216643862 254 722377
SGTC_587 k089-0003 57 µM 1.80726018807402 0.0491262026918591 no 303 0.0353608601796928 154 9659696
SGTC_262 fenpropimorph 62.5 µM 1.80640784476906 0.049208513019918 no 304 0.0354273285592807 262 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_246 cycloheximide 667 µM 1.80138755269381 0.0496955569294319 no 305 0.0358209083320051 220 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_953 1188-0045 9.7 µM 1.79865861547555 0.049961914076288 no 306 0.0360363495550194 323 6144426
SGTC_1693 xanthone 101.9 µM 1.79594324196689 0.0502280761298579 no 307 0.0362517721448193 306 7020 An insecticide.
SGTC_2285 7945142 200 µM 1.78774311814844 0.051038720753142 no 308 0.0369087308760724 296 2970608
SGTC_1967 st070177 51.4 µM 1.7876201513244 0.0510509557385007 no 309 0.0369186560390796 254 5729214
SGTC_2730 imipramine 71.33 µM 1.78317381749954 0.0514949285479144 no 310 0.0372790065679034 354 3696 A tricyclic antidepressant.
SGTC_291 SEC14.278 35.5 µM 1.7827189982218 0.0515405154798088 no 311 0.0373160285811074 276 1068044
SGTC_2886 9058944 51.95 µM 1.781419323145 0.0516709599295537 no 312 0.0374219869154382 133 4949929
SGTC_340 k038-0059 454 µM 1.77676174992178 0.0521405832243291 no 313 0.0378037238350223 311 23733424
SGTC_2167 5876490 200 µM 1.77153072774664 0.0526720626993852 no 314 0.0382362437880708 313 686534
SGTC_2257 7960413 200 µM 1.76926588516946 0.0529035035226408 no 315 0.0384247568642923 329 2974689 YIL048W NEO1
SGTC_2584 androsterone 48.74 µM 1.76520550457278 0.0533204463207549 no 316 0.0387646169145131 471 2754130 A steroid.
SGTC_2647 atorvastatin 60.16 µM 1.76021355873151 0.0538366120170792 no 317 0.0391858019574639 275 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2561 acetosyringone 100 µM 1.75123281975056 0.0547751720865751 no 318 0.0399529071626716 359 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2761 levamisole 97.89 µM 1.74810197102065 0.0551053952408298 no 319 0.0402231858813491 292 26879 An alkaline phosphatase inhibitor.
SGTC_2046 4110841 106 µM 1.7477564972715 0.0551419298870341 no 320 0.0402531005764392 289 44119630 YMR134W ERG29
SGTC_1809 st050081 57.6 µM 1.74585342261225 0.0553435275653999 no 321 0.0404182125863009 294 5036894
SGTC_309 k408-0051 1.48 µM 1.74439776536147 0.0554981216498384 no 322 0.0405448772022891 392 3640463
SGTC_697 0508-1955 564 µM 1.7391233583684 0.0560611328173106 no 323 0.0410065333894396 339 6243113
SGTC_902 1120-0002 2.07 µM 1.73734111356166 0.0562523916660715 no 324 0.0411634893181952 362 3280475
SGTC_575 k072-0246 11.9 µM 1.73647991976747 0.0563449935073428 no 325 0.0412395059394524 308 6796779
SGTC_3020 9089140 49.47 µM 1.72867447743132 0.0571897812474612 no 326 0.0419336858601981 315 17217859
SGTC_2143 5623677 140.463 µM 1.72499807210075 0.0575911190881506 no 327 0.0422639099765699 244 5375313
SGTC_305 1682-2595 20.8 µM 1.72174154159364 0.0579484680385076 no 328 0.0425581742455631 307 226033
SGTC_3231 9132313 49.47 µM 1.71456195144574 0.0587424618315999 no 329 0.0432127848260615 293 4905967
SGTC_148 3253-0744 288.01 µM 1.71375344460544 0.0588324072860596 no 330 0.0432870084404093 302 6893655
SGTC_3081 9117243 49.47 µM 1.71279417552922 0.0589392650118948 no 331 0.0433752060254718 294 45595589
SGTC_441 propafenone 146 µM 1.70776728166846 0.0595017274417247 no 332 0.0438397661355519 256 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_92 0063-0024 660.874 µM 1.7056949336056 0.0597348249701332 no 333 0.0440324467258718 347 3594437
SGTC_2991 9074669 71.4286 µM 1.70353962519075 0.0599780122227472 no 334 0.0442335645466367 389 17333109
SGTC_1166 k206-0078 225 µM 1.70316482801476 0.0600203802763479 no 335 0.0442686133716445 348 5404595
SGTC_1129 3453-1384 223 µM 1.69926853498599 0.0604622168571673 no 336 0.0446342991519393 374 1084452
SGTC_423 5-fluorouracil 457 µM 1.69778321861855 0.0606313190578781 no 337 0.044774342168082 341 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1736 st036774 51 µM 1.69396054909785 0.0610682286204176 no 338 0.0451363899403571 339 1272247
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.69066869066534 0.0614464380722161 no 339 0.0454500486489358 351 688801
SGTC_969 1313-0238 134 µM 1.69037319614979 0.0614804774316467 no 340 0.0454782898296091 377 5212874
SGTC_67 0335-0847 266 µM 1.68553911738112 0.0620394306843035 no 341 0.0459423021616673 499 4552207 YOR254C SEC63
SGTC_595 3909-8003 73.7 µM 1.68482835132454 0.0621219482165287 no 342 0.0460108466320695 324 699517
SGTC_2084 5306078 60.6385 µM 1.68375929086088 0.0622462237366517 no 343 0.0461140987956877 329 679340
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.67893910853928 0.0628089672077344 no 344 0.0465819557996553 333 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2081 5214970 32.255 µM 1.67781407652957 0.0629408805895231 no 345 0.0466917002338011 315 2063512
SGTC_2268 7933382 153.85 µM 1.67532139401963 0.0632339238978314 no 346 0.0469355950309139 404 935025 YOR257W CDC31
SGTC_2845 9003024 42.97 µM 1.6705783512845 0.0637944553729755 no 347 0.0474024957539885 372 2990173
SGTC_862 0452-0056 10.2 µM 1.66611534067137 0.0643254149386545 no 348 0.047845221807897 307 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_256 clotrimazole 625 nM 1.65688463398259 0.0654344728767319 no 349 0.0487714007909558 344 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_3200 9114385 49.47 µM 1.65646427244685 0.0654853296724807 no 350 0.0488139172595867 320 17018030 YLR208W SEC13
SGTC_29 0299-0004 12.984 µM 1.65619001945936 0.0655185262697858 no 351 0.0488416718891512 251 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1504 k297-0033 30 µM 1.65596741774032 0.06554548039994 no 352 0.0488642086382629 273 4388117
SGTC_725 1497-0963 19 µM 1.6543551085783 0.0657409665242398 no 353 0.0490276909736753 333 3549977
SGTC_1378 2093-0007 380 nM 1.65267307471589 0.065945387869656 no 354 0.0491987085297168 366 3618014
SGTC_502 l-744,832 89.3 µM 1.64990166384173 0.0662832775881405 no 355 0.0494815251893271 349 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2841 9004761 38.96 µM 1.64911046386192 0.0663799861006588 no 356 0.0495625031590644 319 2991039
SGTC_3268 9137683 49.47 µM 1.64832077587894 0.0664766187068009 no 357 0.049643431802651 260 1953228
SGTC_781 4335-2806 94.4 µM 1.64532247325344 0.0668445072374147 no 358 0.0499516638785865 390 845254
SGTC_784 4579-0127 173 µM 1.64403227593777 0.0670032969782519 no 359 0.0500847678010927 352 1948547
SGTC_1405 3909-7894 12 µM 1.63369739923837 0.0682857995463044 no 360 0.0511612023696177 345 7104060
SGTC_1788 fluconazole 20 µM 1.63349465548585 0.0683111471019129 no 361 0.0511825019284018 360 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_773 4358-1457 44.6 µM 1.62865638934776 0.0689181962942776 no 362 0.0516928898698095 412 1186886
SGTC_2426 5582046 32.21 µM 1.6264509852409 0.0691962807191643 no 363 0.0519268761163033 380 2251934
SGTC_460 trequinsin 123 µM 1.61991232780977 0.0700258371591693 no 364 0.05262555564883 324 5537 A vasodilator.
SGTC_3128 9127691 49.47 µM 1.61928903665528 0.070105311567798 no 365 0.0526925442223543 315 41316314
SGTC_3176 9106582 49.47 µM 1.61895393208849 0.0701480686438993 no 366 0.0527285877354828 187 17018027
SGTC_1067 clotrimazole 1.36 µM 1.6181110920138 0.0702556980065573 no 367 0.0528193292530756 392 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1844 rapamycin 4 nM 1.61656812989185 0.0704530608609003 no 368 0.0529857679778381 523 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.60567709709168 0.0718582940390445 no 369 0.0541724380038524 372 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2372 9071633 200 µM 1.60549505367266 0.0718819638097231 no 370 0.0541924504296583 390 21321366
SGTC_1629 st005085 44.9 µM 1.60366963343421 0.0721196404927898 no 371 0.0543934464169134 376 24207091
SGTC_286 k060-0067 22.9 µM 1.60349602179298 0.0721422767258293 no 372 0.0544125933659559 363 5985051
SGTC_2109 5483026 200 µM 1.60154296129124 0.0723973005335522 no 373 0.0546283562973064 405 759335
SGTC_547 1120-0019 610 nM 1.60121849670706 0.0724397348086951 no 374 0.0546642667259424 370 3676939
SGTC_147 4466-0538 29.23 µM 1.5915649749603 0.0737109817952928 no 375 0.0557412425913755 415 6742687 YHR072W ERG7
SGTC_1422 4031-0024 15.5 µM 1.59125714892301 0.07375179738757 no 376 0.0557758580962068 360 782427
SGTC_2659 sanguinarine 24.21 µM 1.58953169815454 0.073980900030656 no 377 0.0559702017601868 359 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_906 1165-0455 526 µM 1.58775625303686 0.074217208067957 no 378 0.0561707336463493 336 3252859
SGTC_2705 st078069 42.8 µM 1.58708058369079 0.0743072895326611 no 379 0.0562471973909397 347 1530061
SGTC_1315 1237-0019 3.69 µM 1.5863116796199 0.0744099027621478 no 380 0.0563343120711105 369 825140
SGTC_1409 3909-8004 61.9 µM 1.58015652109744 0.0752352356944545 no 381 0.0570355130367828 397 2119279
SGTC_1830 st055982 50.3 µM 1.57993146330776 0.0752655449730797 no 382 0.0570612814429291 398 455313 An antimicrobial agent.
SGTC_2147 5545932 89.7195 µM 1.57596737628336 0.0758009288377378 no 383 0.0575166609284712 348 797404
SGTC_1191 1487-1166 10.6 µM 1.57554215285339 0.0758585307252192 no 384 0.0575656782966185 462 3955771
SGTC_1132 3456-3614 2.5 µM 1.57495895158497 0.0759375869124733 no 385 0.0576329598896008 485 3125502
SGTC_396 dithiazanine 1.25 µM 1.57334156240958 0.0761571612871785 no 386 0.057819875198396 329 10578 An antihelmenthic.
SGTC_141 0443-0274 32.331 µM 1.57114917505232 0.0764555676544375 no 387 0.0580740012368613 517 1627241
SGTC_1135 dihydrocapsaicin 536.708 nM 1.57078300746183 0.0765054933852275 no 388 0.0581165302017745 399 107982 A Capsaicinoid.
SGTC_2072 5231554 129 µM 1.56915669681906 0.0767275351463483 no 389 0.0583057157516771 355 789545
SGTC_1471 k673-0312 37 µM 1.56728145837924 0.0769841711541912 no 390 0.0585244586896511 371 24099884
SGTC_1786 berberine 21.6 µM 1.56698487830258 0.077024819344005 no 391 0.0585591131188231 408 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1478 0453-0656 35.7 µM 1.5665722903227 0.0770813942840659 no 392 0.0586073494925729 387 5258496
SGTC_75 0159-0059 199.013 µM 1.56632535093764 0.0771152702400843 no 393 0.0586362345211503 363 5377270
SGTC_57 miconazole 162.5 nM 1.56550454089421 0.0772279529601848 no 394 0.058732326746316 357 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.56465434333211 0.0773448019168588 no 395 0.0588319896400867 421 5106787 A p450 inhibitor.
SGTC_936 3005-4620 401 µM 1.56047638800675 0.077920961532374 no 396 0.0593236727893744 419 777207
SGTC_639 0833-0042 114 µM 1.55939509276182 0.0780706064238832 no 397 0.0594514485275719 430 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_573 3702-0553 84.7 µM 1.55882657232247 0.0781493737038768 no 398 0.0595187165825298 380 1222756
SGTC_1102 cgs 12066b 26.1 µM 1.55820848671504 0.0782350765079584 no 399 0.0595919169188753 338 6438352 A 5-HT1B full agonist.
SGTC_2863 9028737 58.44 µM 1.55627672523164 0.0785033911420966 no 400 0.0598211517571614 325 6460917
SGTC_1843 st055809 45.5 µM 1.55550447860803 0.0786108483463954 no 401 0.0599129843869847 366 16413835
SGTC_1491 4138-0063 26.5 µM 1.55058143792869 0.0792985058813994 no 402 0.0605010116546288 344 23883227
SGTC_1849 st056239 19.2 µM 1.54689539949118 0.0798163511738137 no 403 0.0609442352975367 416 5393181
SGTC_2630 antimycin a 100 µM 1.54429507715987 0.0801832018445986 no 404 0.0612584323132181 444 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1539 benzyladenosine 56 µM 1.54324333518558 0.080331941923037 no 405 0.0613858732404243 359 92208 A nucleotide analog.
SGTC_499 genistein 192 µM 1.5432355980711 0.080333036897854 no 406 0.0613868115233528 312 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1998 st075797 76.8 µM 1.54285979778414 0.0803862346255359 no 407 0.0614323984612765 436 24208315
SGTC_942 3253-1115 227 µM 1.54190088353381 0.0805220977060604 no 408 0.0615488406152385 394 46497897
SGTC_19 0279-0214 38.434 µM 1.53892958128532 0.0809441860500142 no 409 0.0619107442705686 497 3566274 YBR002C RER2
SGTC_1941 st076221 61.8 µM 1.53463515415835 0.0815571792731076 no 410 0.0624367362342368 474 2828568
SGTC_479 n-linoleoylglycine 10 µM 1.53107871823163 0.0820674749732437 no 411 0.0628749694228675 346 6433346 An anti-infammatory.
SGTC_1167 k781-0610 148 µM 1.52885015014234 0.0823884650736719 no 412 0.0631507983116017 450 4525169
SGTC_911 3456-4043 236 µM 1.52059287876221 0.0835860376774002 no 413 0.0641810174894531 433 914281
SGTC_1420 4'-methoxyflavone 42 µM 1.51970877815874 0.083715032221743 no 414 0.064292092206326 377 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1801 st050089 28.441 µM 1.51481539025705 0.0844317068999806 no 415 0.0649095809347853 539 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_334 1502-1024 68.5 µM 1.51246334168504 0.0847778164216823 no 416 0.0652080157872951 414 3296216
SGTC_231 b-estradiol 524 µM 1.51015097725052 0.0851191223643694 no 417 0.0655024521613797 337 450 A steroid.
SGTC_13 0199-0087 65 µM 1.50839218262221 0.0853794098646696 no 418 0.0657270912948968 426 4589825
SGTC_1392 3455-1037 33.9 µM 1.50640676188591 0.0856739520857212 no 419 0.065981392959893 417 981132
SGTC_2124 5246320 200 µM 1.50133799106999 0.0864293665500228 no 420 0.0666340817165515 410 579342
SGTC_2146 5545642 200 µM 1.5005880350245 0.0865415564362363 no 421 0.0667310739697805 406 825326
SGTC_1934 st074720 32.6 µM 1.48969862792006 0.0881828473818702 no 422 0.0681517477773884 490 17250992
SGTC_40 0327-0103 19.753 µM 1.48212571073686 0.0893378697895229 no 423 0.0691534244013451 430 409036
SGTC_255 tunicamycin 200.472 nM 1.48080948403166 0.0895397637329426 no 424 0.0693286742736774 462 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.47992335810483 0.0896758761771072 no 425 0.0694468506479303 438 115019
SGTC_386 1509-0011 3.07 µM 1.47677110754713 0.09016132135471 no 426 0.0698685019300359 548 3107280
SGTC_655 k060-0012 42 µM 1.47278386950249 0.0907781470713969 no 427 0.0704046615823892 432 5994525
SGTC_2284 7945075 39.21 µM 1.47073624297343 0.0910961293155317 no 428 0.0706812303367568 492 1245402
SGTC_1031 k035-0009 16 µM 1.47032188416578 0.0911605767508563 no 429 0.0707372983735114 481 5180959
SGTC_2629 bisabolol 100 µM 1.46644676433222 0.0917649322642416 no 430 0.071263307095557 461 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_630 4356-0227 183 µM 1.46434347653212 0.0920941967424486 no 431 0.0715500618302075 421 779312
SGTC_3012 9080433 71.4286 µM 1.4641928182624 0.0921178154485969 no 432 0.0715706359717392 452 17688859
SGTC_755 1995-0008 37.3 µM 1.46359943841089 0.0922108832585441 no 433 0.0716517130511001 427 689533
SGTC_2197 6588183 93.1375 µM 1.46109715598298 0.0926041158295228 no 434 0.0719943903066126 379 884136
SGTC_293 4049-0273 38.5 µM 1.46083780785904 0.0926449431104639 no 435 0.0720299787067327 395 1380311
SGTC_3119 9125183 49.47 µM 1.45920336047677 0.0929025486107015 no 436 0.0722545720881069 309 22695334
SGTC_2881 9058953 51.95 µM 1.45862863069392 0.0929932575930248 no 437 0.0723336745128699 461 17122249
SGTC_3076 9116187 49.47 µM 1.45376838464394 0.093762964159058 no 438 0.0730052657423474 413 27241210
SGTC_2771 fluoxetine 41.05 µM 1.45030388215593 0.0943144940824239 no 439 0.0734868984826247 417 3386 A selective serotonin reuptake inhibitor.
SGTC_3143 9086658 49.47 µM 1.44926638595976 0.0944801224516129 no 440 0.073631602244999 512 25236626
SGTC_3219 9131112 49.47 µM 1.44696626858718 0.0948480832460235 no 441 0.0739531855720261 433 17612988 YMR079W SEC14
SGTC_407 eburnamonine 100 µM 1.44687128358205 0.0948633011231843 no 442 0.0739664886247014 378 3195
SGTC_2461 5755302 26.15 µM 1.44077484291495 0.0958438000249601 no 443 0.0748241514203109 495 2788904
SGTC_1441 4106-0040 13 µM 1.44020029221741 0.0959365887596841 no 444 0.0749053702899745 438 2904180
SGTC_3337 9144342 33.5465 µM 1.43209300912937 0.0972529484059122 no 445 0.0760586024567692 456 17682949
SGTC_1290 0986-0249 10.2 µM 1.43011033354639 0.0975768780356424 no 446 0.0763426774197913 409 53329
SGTC_1605 st000082 49.1 µM 1.42917764981724 0.0977295333053057 no 447 0.076476589932146 425 1114022
SGTC_1846 st056244 14.8 µM 1.42447372766682 0.0985021078736155 no 448 0.0771546925217141 491 5393182
SGTC_889 0919-1524 82.7 µM 1.42337991943101 0.0986823945388006 no 449 0.0773130252032961 444 3905452
SGTC_2686 alizarin 95.37 µM 1.42126839740314 0.0990311085255399 no 450 0.077619373585317 438 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1871 st057448 67.3 µM 1.42084934215521 0.0991004217928542 no 451 0.0776802813147304 491 691747
SGTC_100 0086-0128 49.5915 µM 1.4186214897359 0.0994695125188482 no 452 0.0780046986344909 531 93297
SGTC_669 0108-0021 26.2 µM 1.41774921804235 0.0996142960891025 no 453 0.0781319975008712 589 17201
SGTC_2319 6033012 152.6 µM 1.41631102734124 0.0998533496031916 no 454 0.0783422303063843 399 847246
SGTC_1950 st077106 7.18 µM 1.41599049682415 0.0999066846730234 no 455 0.0783891434305656 475 13831864
SGTC_480 am 92016 50 µM 1.41439820363575 0.100171944683822 no 456 0.0786225086195518 410 2129 K+ channel blocker.
SGTC_2300 7976697 71.57 µM 1.41234686908531 0.100514433712415 no 457 0.078923926177454 396 2236109
SGTC_105 0111-0055 734.78 µM 1.4114139462243 0.100670476006817 no 458 0.079061296570841 386 5179370
SGTC_1306 1185-0270 9.02 µM 1.41011903491834 0.100887357836652 no 459 0.0792522687908919 516 1548076
SGTC_2860 9025725 38.96 µM 1.40870646402743 0.101124334497771 no 460 0.0794609913808731 425 40546248
SGTC_764 1951-2361 146 µM 1.40260718196447 0.10215222429907 no 461 0.0803670044908059 507 5438930
SGTC_2036 5160441 105 µM 1.40241831942658 0.10218417349495 no 462 0.0803951830083379 557 134534 YIL048W NEO1
SGTC_1279 0874-0590 65.2 µM 1.40175141335723 0.102297049747278 no 463 0.0804947459186535 474 3523074
SGTC_3186 9110464 49.47 µM 1.40023085720404 0.102554748385843 no 464 0.0807220991552037 473 17018021
SGTC_1854 st056233 32.9 µM 1.39942643800947 0.102691269312961 no 465 0.08084257170096 461 5393174
SGTC_2277 7947813 106.88 µM 1.39882572428105 0.102793304754419 no 466 0.0809326251238023 470 1246798
SGTC_1650 st011916 45.8 µM 1.39873394076679 0.102808901314239 no 467 0.0809463911220325 427 242528
SGTC_546 peri-Naphthalide 147 µM 1.39344044107136 0.103711325053357 no 468 0.0817433218242991 487 223824 A penicillin ester.
SGTC_2111 5486399 200 µM 1.39165628075188 0.104016775756053 no 469 0.0820132536141516 534 689674
SGTC_2137 5261020 140 µM 1.3897837814698 0.10433805122342 no 470 0.0822972722436359 471 763655
SGTC_1574 spiramycin 23.7 µM 1.38830962981733 0.104591485371803 no 471 0.0825213905639682 492 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_939 1165-0479 45.3 µM 1.38826285865002 0.104599533499315 no 472 0.0825285087936109 507 1377347
SGTC_2822 7994718 71.43 µM 1.38744871731453 0.104739698375602 no 473 0.0826524892111444 408 1018011
SGTC_871 0574-0004 149 µM 1.3860556611157 0.104979846272242 no 474 0.082864953950253 539 9551173
SGTC_858 0438-0351 2.77 µM 1.3840621616556 0.105324197053964 no 475 0.0831697108536793 515 2799119
SGTC_1383 3049-0032 20.7 µM 1.37934897272624 0.106141586570238 no 476 0.0838935919765904 508 712864
SGTC_1665 st014639 11.4 µM 1.3790522588403 0.106193197377356 no 477 0.0839393209746861 549 981133 YIL048W NEO1
SGTC_2853 9015042 58.44 µM 1.37762805850105 0.10644117700897 no 478 0.0841590766837621 451 6457456
SGTC_2025 5147754 141 µM 1.37574616898402 0.106769489671841 no 479 0.0844501163324465 460 315777 YLR208W SEC13
SGTC_2152 5568786 200 µM 1.37234689204114 0.107364375229436 no 480 0.0849777372066223 494 5399883
SGTC_1458 k015-0034 6.33 µM 1.36509191416586 0.108642005428737 no 481 0.0861120815542927 471 3598957
SGTC_2975 9084847 53.72 µM 1.36244692663807 0.109110507492938 no 482 0.0865284413709598 504 27211724
SGTC_3009 9080819 71.4286 µM 1.35916688876274 0.109693509299263 no 483 0.0870468554883468 499 17027216
SGTC_3209 9113616 49.47 µM 1.35821568534651 0.10986299602567 no 484 0.0871976274381175 544 16649353
SGTC_1010 4112-3296 15.2 µM 1.35182348612183 0.111006843393381 no 485 0.0882158945037311 549 704384
SGTC_1120 ficusin 1.78878 µM 1.34861128345904 0.111584858062838 no 486 0.0887309272564505 522 6199 A DNA cross-linker.
SGTC_1369 1866-0067 208 µM 1.34814729367236 0.111668527634483 no 487 0.0888055063828999 577 3531355
SGTC_1813 st051246 8.6015 µM 1.34632993556049 0.111996677297497 no 488 0.089098067846105 466 5291959
SGTC_1030 k029-0042 36.7 µM 1.34482087069543 0.112269683745457 no 489 0.0893415443401735 563 6080581
SGTC_1496 4469-0713 57.4 µM 1.34117979920458 0.112930350885471 no 490 0.0899310417014841 513 746691
SGTC_1278 0874-0585 172 µM 1.33843382386513 0.1134304364815 no 491 0.0903775295460953 521 766306
SGTC_486 niguldipine 82 µM 1.3369784856934 0.113696116014237 no 492 0.0906148297994821 447 1236 A calcium channel blocker.
SGTC_2385 9074692 200 µM 1.33308917658801 0.114408305470541 no 493 0.0912512704102463 529 17046906
SGTC_1195 1502-0147 41.1 µM 1.33261187502567 0.114495924692995 no 494 0.0913296030764892 554 817940
SGTC_3297 9117502 71.43 µM 1.3325184382429 0.114513082662987 no 495 0.091344943349702 488 7453720
SGTC_2406 ethylparaben 405.7 µM 1.33237320879841 0.114539755048618 no 496 0.091368790635283 455 8434 A possible steroid mimic.
SGTC_840 0245-0196 390 µM 1.32951805578841 0.115065021731633 no 497 0.0918385564505334 587 3827528
SGTC_2178 5812956 200 µM 1.32940674148475 0.115085535022568 no 498 0.0918569074510483 481 5403383
SGTC_1470 k295-0292 231 µM 1.32844641682268 0.115262614154914 no 499 0.0920153369965763 548 5045612
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.32824801832761 0.115299221986446 no 500 0.0920480929887452 615 91467 include heat shock
SGTC_142 0335-0849 62.6745 µM 1.32495068659467 0.115908845049417 no 501 0.0925937539019121 657 3889043 YPR107C YTH1
SGTC_194 1486-1323 56.904 µM 1.32359675167574 0.116159827260921 no 502 0.0928185022828063 520 5178754
SGTC_2187 6125751 200 µM 1.32153029959273 0.116543633680891 no 503 0.0931623032501399 540 874498
SGTC_3248 9135562 49.47 µM 1.32072502029603 0.116693443137289 no 504 0.093296534157964 572 17650701
SGTC_389 tpck 16.7 µM 1.31961745179619 0.116899711676333 no 505 0.0934813865839536 524 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.31902384495799 0.117010368629567 no 506 0.093580570434361 563 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_295 k015-0027 31 µM 1.31816068480872 0.117171406649996 no 507 0.0937249317012775 512 3887424
SGTC_1072 oxiconazole 14.9 nM 1.31694553054622 0.117398381502807 no 508 0.0939284416168841 571 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_125 0133-0007 11.75 µM 1.31548539349787 0.117671527537338 no 509 0.0941734115643582 555 26541
SGTC_390 dec-rvkr-cmk 16.7 µM 1.31510258214682 0.117743213949351 no 510 0.0942377144588648 561 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_876 0720-0963 56.8 µM 1.31210164220106 0.118306249963146 no 511 0.0947429209900556 579 765861
SGTC_991 3996-0057 64.7 µM 1.31189740818136 0.118344637390344 no 512 0.0947773760747439 525 715343
SGTC_635 k038-0028 24.7 µM 1.31057116083639 0.118594130505078 no 513 0.0950013439288504 553 4035102
SGTC_3232 9132874 49.47 µM 1.30885816085749 0.118916929103809 no 514 0.0952912006667988 503 3784940
SGTC_2016 5121758 140 µM 1.30772880403894 0.119130084787361 no 515 0.0954826549689422 597 2795203
SGTC_2221 6807166 181.081 µM 1.30400501806343 0.119834825463788 no 516 0.0961159357176494 450 674925
SGTC_138 0850-0259 40.9225 µM 1.30214808045563 0.120187354230495 no 517 0.096432884846082 680 6813004
SGTC_2595 hexamethylquercetagetin 100 µM 1.29566533936762 0.121423790979506 no 518 0.0975454038063648 539 386331
SGTC_3218 9131285 49.47 µM 1.2928218570638 0.121968933044228 no 519 0.0980363395210035 631 17156417
SGTC_3133 9127736 49.47 µM 1.28500164228944 0.123477053352246 no 520 0.0993958550689863 558 27243420
SGTC_2813 7971799 71.43 µM 1.28360821381827 0.123747139756285 no 521 0.0996395371576595 511 2234054
SGTC_55 0767-0285 6.563 µM 1.27998232089216 0.124451879339618 no 522 0.100275676815302 601 3116166
SGTC_1978 st071761 42 µM 1.27622721661052 0.125184685905649 no 523 0.100937605136736 527 5147680
SGTC_2951 9072950 58.06 µM 1.27518315544739 0.125388968140968 no 524 0.101122210982093 593 16488155
SGTC_211 3455-0679 143.504 µM 1.27318174386384 0.125781216990775 no 525 0.101476778616421 583 748649
SGTC_1862 st057513 3.81 µM 1.27154548926442 0.126102535445043 no 526 0.101767327570185 540 5393163
SGTC_866 0495-0101 262 µM 1.26787339699887 0.126825722075296 no 527 0.10242158287784 544 635694
SGTC_179 1273-0063 6.77 µM 1.26785573204273 0.126829207999158 no 528 0.102424737611226 517 3108139
SGTC_2003 4023581 200 µM 1.2645086637688 0.127490907616859 no 529 0.103023756522347 557 16641307
SGTC_3167 9103034 49.47 µM 1.26387836474745 0.127615782874255 no 530 0.103136844174388 486 5127859
SGTC_2189 6047310 154.431 µM 1.26027311998931 0.128331690478795 no 531 0.10378542662723 548 711535
SGTC_2661 dactinomycin 12.96 µM 1.25996328165274 0.12839334615517 no 532 0.103841304205515 612 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2825 7998094 58.44 µM 1.25805030214609 0.128774471216297 no 533 0.104186782480633 558 2987815
SGTC_715 0868-0130 184 µM 1.25782572973127 0.128819264455214 no 534 0.10422739415851 533 2876258
SGTC_661 1304-0007 33.6 µM 1.25601924964168 0.129179978345656 no 535 0.104554495489005 555 3117130
SGTC_344 k064-0035 6.43 µM 1.25123838799832 0.130137986611333 no 536 0.105423758268753 559 5088750
SGTC_2914 7968218 45.32 µM 1.25070712667851 0.130244745628433 no 537 0.105520674700764 537 2977111
SGTC_259 usnic acid 108.925 µM 1.24990407342598 0.130406237285052 no 538 0.10566729561833 596 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1718 roemerine 11.9335 µM 1.24893556309455 0.130601186049588 no 539 0.105844321456067 641 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2288 7946289 167.31 µM 1.2478811318497 0.13081365860993 no 540 0.106037295672773 649 1246052
SGTC_1165 k072-0275 30.3 µM 1.24769614977005 0.130850957936539 no 541 0.10607117592028 555 6153523 YGL055W OLE1
SGTC_750 4073-0104 132 µM 1.24371617008964 0.131655251824288 no 542 0.106802021290389 473 22330957
SGTC_2196 6573537 42.6665 µM 1.23758650508875 0.132900626414764 no 543 0.107934710389711 557 2903087
SGTC_1265 0819-1001 68.8 µM 1.2290001428535 0.134658733426394 no 544 0.109535876229498 563 3106768
SGTC_1619 st003326 88.7 µM 1.22725382862789 0.135018245668192 no 545 0.109863601698735 556 2849032
SGTC_3298 9116858 71.43 µM 1.22360734076003 0.13577106594306 no 546 0.110550194530754 627 2506942
SGTC_1443 4112-3303 14 µM 1.22299288888593 0.135898202488753 no 547 0.110666191086395 615 704433
SGTC_2955 9076254 12.21 µM 1.21896977171862 0.136732641663852 no 548 0.11142783290374 559 16459619
SGTC_572 0960-0087 17.7 µM 1.21643448634721 0.137260283602533 no 549 0.111909726743731 648 6796365
SGTC_1479 0549-0158 134 µM 1.21427123488298 0.137711596259536 no 550 0.112322083112521 685 5440202
SGTC_3160 9100216 49.47 µM 1.21332914666772 0.137908457477741 no 551 0.112502001788683 611 17191039
SGTC_2395 5646831 180.19 µM 1.20663586879381 0.139312628659418 no 552 0.113786203409984 615 6808628
SGTC_482 fipronil 114 µM 1.20490591869708 0.13967712839417 no 553 0.114119811740101 548 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2483 5729050 27.16 µM 1.20359065465111 0.139954687496527 no 554 0.114373916659731 715 2865180
SGTC_3150 9097574 49.47 µM 1.20005297400609 0.140703100290304 no 555 0.115059383735408 592 17217476
SGTC_1415 3966-0071 78.1 µM 1.19541294426593 0.141688830582123 no 556 0.115962865377032 613 2893185
SGTC_1181 1222-0449 220 µM 1.19453083432316 0.141876754362004 no 557 0.116135193314112 643 658318
SGTC_3054 9094397 49.47 µM 1.19053385187793 0.142730381638199 no 558 0.116918316508373 655 2598354
SGTC_1345 1488-0192 31.4 µM 1.18851560204032 0.143162731682336 no 559 0.117315168342412 632 658348
SGTC_3196 9111891 49.47 µM 1.18583618803312 0.143738082039011 no 560 0.117843498655961 605 18891510
SGTC_943 3253-1379 105 µM 1.18511719345498 0.143892736829161 no 561 0.117985556993395 626 668464
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.18150468010328 0.144671482122438 no 562 0.118701147672495 702 688761
SGTC_2790 5423970 71.43 µM 1.17919160736865 0.145171596585564 no 563 0.119160943616924 676 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1524 corynanthine 62.1 µM 1.17522976833281 0.146030894364129 no 564 0.119951401848102 615 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_754 3474-0146 171 µM 1.17171932157233 0.146795137837348 no 565 0.12065488153171 601 24762078
SGTC_413 propylparaben 100 µM 1.17167262477369 0.14680532203679 no 566 0.120664258920569 620 7175 A pharmaceutical preservative.
SGTC_481 bay k-8644 50 µM 1.17067759055997 0.147022443723135 no 567 0.120864198064106 597 2303 A calcium channel antagonist.
SGTC_1867 st057372 64 µM 1.16993641496434 0.147184311994558 no 568 0.12101327906722 635 688837
SGTC_861 0443-0273 110 µM 1.16878110819478 0.147436862176767 no 569 0.121245916863032 658 6149169
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.16387701655193 0.148512127895839 no 570 0.122236927484112 664 3256 An antibiotic and ribosome inhibitor.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 1.16368498527504 0.148554338877268 no 571 0.122275848198698 628 803109
SGTC_7 0192-1582 4.227 µM 1.1625754380044 0.14879838891756 no 572 0.122500900513881 762 252616
SGTC_2058 5236698 133 µM 1.16100368634877 0.149144561326965 no 573 0.122820200159557 629 766665
SGTC_268 camptothecin 39.6153 µM 1.16025770462196 0.149309049079335 no 574 0.1229719496048 755 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_684 1140-0066 328 µM 1.15912472366974 0.149559101116042 no 575 0.123202674732412 702 6813534
SGTC_3106 9121286 49.47 µM 1.1585781794359 0.149679824807925 no 576 0.123314083761163 592 15943471
SGTC_3045 9092950 49.47 µM 1.15781485518675 0.14984854084313 no 577 0.123469799910741 699 44120432
SGTC_1362 1611-0397 101 µM 1.15557206532682 0.150344993800212 no 578 0.123928119851205 663 27816
SGTC_3132 9126706 49.47 µM 1.15515245490766 0.150437998269609 no 579 0.124014000386031 627 850858
SGTC_511 blebbistatin 171 µM 1.1510947707707 0.151339340072656 no 580 0.124846624536115 648 3476986 A myosin inhibitor.
SGTC_1915 st067105 30.6 µM 1.15070211540318 0.151426751621614 no 581 0.124927402980736 668 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2833 9001315 45.46 µM 1.14878870625928 0.151853188317553 no 582 0.125321558709999 672 2989378
SGTC_3025 9087895 49.47 µM 1.14858182674213 0.151899342787796 no 583 0.125364227132541 716 17173641
SGTC_1349 flufenamic acid 69 µM 1.14526667025394 0.152640219783526 no 584 0.126049354050602 637 3371 A non-steroidal anti-inflammatory.
SGTC_1282 0886-0010 32.4 µM 1.14468862291055 0.15276964784612 no 585 0.126169082988855 746 2836211 YNL267W PIK1
SGTC_1460 k062-0059 9.15 µM 1.1430535272685 0.153136149022585 no 586 0.126508183840707 659 1373085
SGTC_2405 ticlatone 3.52 µM 1.1410619786676 0.153583334437349 no 587 0.126922066030667 621 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1660 st012960 28.1 µM 1.13662639567058 0.154582411852805 no 588 0.127847250374871 652 24207266
SGTC_2015 5119600 184 µM 1.13524870377207 0.154893597563211 no 589 0.128135564117671 690 2828786
SGTC_1640 st009078 66.4 µM 1.13322244268455 0.155352029924254 no 590 0.128560425897882 601 690618
SGTC_1826 st055655 41.6 µM 1.13281311968187 0.155444745989818 no 591 0.128646370369125 693 676168
SGTC_3350 9150499 3.57 µM 1.13058974436939 0.15594900207209 no 592 0.12911390302117 740 4910996 YPR165W RHO1
SGTC_1884 5633444 25 µM 1.1284748168738 0.156429661983665 no 593 0.12955972322556 687 5724239
SGTC_1365 1672-3266 55.4 µM 1.12826823858092 0.15647666331083 no 594 0.129603326393103 727 6415873
SGTC_1252 0493-0875 34.8 µM 1.12610778262123 0.15696877400837 no 595 0.130059950114339 658 3960963
SGTC_213 1246-0773 967 nM 1.12250648164458 0.157791342379854 no 596 0.130823576608301 720 6251622
SGTC_1259 0671-0132 43 µM 1.121332697668 0.158060055473709 no 597 0.131073136186226 672 X1259
SGTC_117 lucigenin 22.078 µM 1.11906479075079 0.158580095360632 no 598 0.131556249644997 725 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2524 avocatin b 10.57 µM 1.11670700449988 0.159121933201812 no 599 0.132059810975502 627 6710748
SGTC_1681 tripelennamine 100 µM 1.11656487215011 0.159154635047363 no 600 0.132090209139804 608 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2434 5670830 169.91 µM 1.11469001255031 0.159586415207016 no 601 0.132491641183516 685 1549830
SGTC_3078 9116413 49.47 µM 1.11190737918202 0.160228667666179 no 602 0.133088987813141 624 17177322
SGTC_801 0866-0028 10.1 µM 1.10864093310008 0.160984740379475 no 603 0.133792556190033 738 6849771
SGTC_198 3454-2873 16.191 µM 1.10631326033032 0.161524937127414 no 604 0.134295477136773 692 710957
SGTC_2634 4'-methoxyflavone 100 µM 1.10314100515229 0.162263041721777 no 605 0.134982968018751 646 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3006 9075424 71.4286 µM 1.10079539651838 0.162810216137813 no 606 0.135492857883379 664 7465181
SGTC_839 0122-0028 230 µM 1.1007787332995 0.162814107555937 no 607 0.135496484859272 745 759448
SGTC_3098 9119039 49.47 µM 1.09848756727581 0.163349747256529 no 608 0.135995821813857 705 17161528
SGTC_2032 5185112 25.99 µM 1.09806090070351 0.163449621696588 no 609 0.13608894853596 654 5718189
SGTC_2808 7946468 45.46 µM 1.09783899005984 0.163501582386092 no 610 0.136137401291993 745 2970879
SGTC_931 2812-0076 566 µM 1.09721258365321 0.163648314200674 no 611 0.136274236784003 737 3450959
SGTC_757 1066-0008 322 µM 1.09559832033251 0.164026839280984 no 612 0.136627298549454 755 6842497
SGTC_1152 3909-8331 15.9 µM 1.09428270403843 0.164335755036235 no 613 0.136915504294628 673 16001939
SGTC_145 3737-0113 38.366 µM 1.08976530787234 0.165399339916656 no 614 0.137908269764842 808 6849351
SGTC_2371 9071574 200 µM 1.08886480059121 0.165611888359344 no 615 0.138106755270808 662 45596039
SGTC_1940 st075990 51.1 µM 1.08676062831668 0.166109228395236 no 616 0.138571305969817 788 1084979
SGTC_916 4466-0038 42 nM 1.08563662312989 0.166375292098097 no 617 0.138819895085091 851 5722064 YGL116W CDC20
SGTC_3283 9109332 35.8195 µM 1.07515040586573 0.168870737333296 no 618 0.141153697589214 630 17027281
SGTC_2560 caryophyllene 100 µM 1.07255002195983 0.169493262597676 no 619 0.141736529448199 795 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2079 5212404 121 µM 1.07210225833726 0.169600604487479 no 620 0.141837052317578 740 758462
SGTC_2648 atorvastatin 78.68 µM 1.0719505858418 0.169636974657162 no 621 0.141871113715019 713 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3030 9087619 49.47 µM 1.07186884928052 0.16965657667683 no 622 0.141889471755536 694 25236973
SGTC_124 0136-0217 7.121 µM 1.06870075309363 0.170417467253236 no 623 0.14260226604472 855 3976905
SGTC_2252 omeprazole 400 µM 1.06780876882324 0.170632091322319 no 624 0.142803390893341 642 4594 A proton pump inhibitor.
SGTC_675 1309-0189 238 µM 1.06736845898829 0.170738099877796 no 625 0.142902742723792 721 4246530
SGTC_1318 1280-3875 124 µM 1.06354719063576 0.171659874393535 no 626 0.143766938241439 759 373245
SGTC_2857 9024691 58.44 µM 1.06231106991876 0.171958733351118 no 627 0.144047245290965 698 16478292
SGTC_3056 9094900 49.47 µM 1.0616994755036 0.172106722313145 no 628 0.144186068772855 724 25236784
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.06138323872022 0.172183274756407 no 629 0.144257885519453 827 65057 A dermal irritant. YDR527W RBA50
SGTC_484 loperamide 105 µM 1.06038922533821 0.172424040203849 no 630 0.144483780983243 637 3955 An opioid-receptor agonist.
SGTC_3013 9080133 71.4286 µM 1.05897086555255 0.172767960550071 no 631 0.144806524189579 806 17050193
SGTC_2786 7743617 45.45 µM 1.05754727027637 0.173113589738693 no 632 0.1451309465294 656 583674
SGTC_1728 st035614 33.7865 µM 1.05668683659901 0.173322704489621 no 633 0.145327267274488 806 15945546
SGTC_609 0986-0026 86.3 µM 1.05657957987128 0.173348782803878 no 634 0.145351752010017 757 2848610
SGTC_1236 0330-0013 258 µM 1.05401271287171 0.173973633913216 no 635 0.145938548396139 727 4617066
SGTC_273 hydroxyurea 18.1 mM 1.05301738975101 0.174216309737925 no 636 0.146166511073217 831 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_3270 9137563 49.47 µM 1.05191664301994 0.174484939919139 no 637 0.146418897697929 702 17015724
SGTC_612 0302-0167 22.4 µM 1.04863282484214 0.17528789681406 no 638 0.147173571124213 828 235821
SGTC_2463 5473429 200 µM 1.04552546778307 0.176049859547383 no 639 0.147890088114503 725 5399405
SGTC_1705 st027868 56.3335 µM 1.04515820301746 0.176140055817349 no 640 0.147974928757705 744 292948
SGTC_496 calpeptin 138 µM 1.04494617361781 0.176192141269463 no 641 0.148023923812549 661 73364 A calpain inhibitor.
SGTC_1224 0823-0416 294 µM 1.03975336729906 0.177470806517226 no 642 0.149227249716375 782 3598164
SGTC_2478 5763493 32.33 µM 1.03882448077321 0.177700149604859 no 643 0.149443186850728 787 1365576 YLR208W SEC13
SGTC_1400 3771-8998 51.5 µM 1.03668241154347 0.178229741258884 no 644 0.149941945816548 719 670767
SGTC_1850 st056238 17 µM 1.0356126499161 0.178494594403265 no 645 0.150191444026859 809 5393177
SGTC_26 0302-0163 425.158 µM 1.03416355188488 0.17885375934747 no 646 0.150529855109306 769 3100915
SGTC_1222 0366-0074 1.18 µM 1.03407851301836 0.178874850703659 no 647 0.150549730189931 826 286520
SGTC_3058 9093861 49.47 µM 1.03387779966528 0.178924637875954 no 648 0.150596647366152 751 17217477
SGTC_3065 9113888 49.47 µM 1.03364915460895 0.178981364163334 no 649 0.150650105501588 708 16648368
SGTC_785 1270-0111 65.3 µM 1.03048899259961 0.179766551545882 no 650 0.151390258397987 760 6741994
SGTC_2656 pseudo-anisatin 100 µM 1.02745268491121 0.180523000679347 no 651 0.152103677091427 773 6708809 A neurotoxin.
SGTC_1156 4092-0367 4.88 µM 1.0271279821805 0.180604013350808 no 652 0.152180102012984 770 1357585
SGTC_888 0916-0002 6.97 µM 1.02482543010183 0.181179149318087 no 653 0.152722782521053 824 2802138 YIL048W NEO1
SGTC_476 mead acid 10 µM 1.0210747694679 0.182118449870761 no 654 0.15360950788706 710 5312531 An omega 9 fatty acid.
SGTC_3306 9127676 59.7925 µM 1.02100048884964 0.182137083102505 no 655 0.153627103552792 742 41905287
SGTC_229 benomyl 22.8748 µM 1.02020043381571 0.182337851782986 no 656 0.153816705969252 781 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1445 4239-0156 97.7 µM 1.01917337198844 0.182595788975625 no 657 0.154060332925734 866 4008346
SGTC_1982 st072467 71.9 µM 1.01791187788945 0.18291291334112 no 658 0.154359918176346 830 3163533
SGTC_2657 nystatin 74.44 µM 1.01551089800454 0.183517439630801 no 659 0.154931177160968 809 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1105 epirubicin 18.1 µM 1.01489832657823 0.183671873959092 no 660 0.155077147992084 765 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1096 rimcazole 32.2 µM 1.01313208401968 0.184117611486137 no 661 0.15549853757169 754 18528119 A dopamine reuptake inhibitor.
SGTC_2591 skatole 100 µM 1.013041076905 0.184140596709188 no 662 0.155520270465223 767 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1692 fluoroquinolonic acid 71 µM 1.01045089891485 0.184795534001645 no 663 0.156139656286226 774 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2621 lithochol-11-enic acid 100 µM 1.01011150529179 0.184881458257917 no 664 0.156220935310316 831 6708711
SGTC_2620 irigenin 100 µM 1.00987227624759 0.184942038772104 no 665 0.156278243359833 814 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3079 9117512 49.47 µM 1.00986534832847 0.184943793328556 no 666 0.156279903170358 865 7185044
SGTC_3068 9116768 49.47 µM 1.00956566236202 0.185019701336403 no 667 0.156351713900797 731 41904888
SGTC_1079 idarubicin 2.36 µM 1.00866416196741 0.18524816069362 no 668 0.156567862362613 769 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1909 st060837 51.5 µM 1.00831267993555 0.185337281153744 no 669 0.15665218881553 746 678937
SGTC_136 0097-0015 404.482 µM 1.00748589331914 0.185547022986284 no 670 0.1568506666883 861 4861337
SGTC_2677 mitomycin C 100 µM 1.00669638125386 0.185747446326358 no 671 0.157040350835084 751 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2937 9044753 11.33 µM 1.00306532901342 0.186670943220406 no 672 0.157914670855148 830 6465530 YGL099W LSG1
SGTC_393 acivicin 6.25 µM 1.0006186952088 0.187294803329179 no 673 0.158505594114756 738 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3043 9092303 49.47 µM 0.998317629358631 0.187882720308064 no 674 0.159062680807755 734 25236084
SGTC_2626 ethyl orsellinate 100 µM 0.998232179531751 0.187904574462146 no 675 0.159083392832931 756 75653 A natural product.
SGTC_1881 5652484 16 µM 0.997054570232007 0.1882059128617 no 676 0.159369011320268 770 2255129
SGTC_2861 9024595 19.48 µM 0.995965112722096 0.188484959488941 no 677 0.159633548203946 735 16482810
SGTC_920 mycophenolic acid 780.421 nM 0.994515109872368 0.188856749413605 no 678 0.159986076477302 776 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2723 salbutamol 83.58 µM 0.993280001973656 0.189173795044996 no 679 0.160286760183657 728 9884233 β2-adrenoceptor agonist
SGTC_1901 st060216 58.6 µM 0.992810224855791 0.189294470319099 no 680 0.160401223058467 820 688792
SGTC_706 4262-0057 46.9 µM 0.992594068794006 0.189350011910518 no 681 0.160453908193373 783 883298
SGTC_1966 st070145 16.1 µM 0.992249114944625 0.189438669042179 no 682 0.160538009474219 781 3748532
SGTC_165 k038-0023 64.381 µM 0.99088132085165 0.189790459363413 no 683 0.160871767162279 815 46368543
SGTC_1404 3909-7820 48.3 µM 0.989697943617813 0.190095142432236 no 684 0.161160890213407 807 23741373
SGTC_1274 0865-0114 173 µM 0.989362510362227 0.190181560777452 no 685 0.161242904989568 802 870624
SGTC_852 0418-0143 439 µM 0.987671795215573 0.190617510481375 no 686 0.16165670602415 896 5369229
SGTC_3190 9110366 49.47 µM 0.987093549223452 0.190766751467405 no 687 0.161798389930649 715 17123768
SGTC_2443 5493264 126.67 µM 0.98685000604319 0.19082962960259 no 688 0.161858087964156 823 5340055
SGTC_1188 1403-0014 4.57 µM 0.985825730424735 0.191094216917632 no 689 0.162109318553108 864 9614867
SGTC_2557 derrustone 83.84 µM 0.984483420183995 0.191441298213673 no 690 0.162438939769035 832 629853 An antioxidant.
SGTC_2649 anisomycin 9.56 µM 0.9834619743621 0.191705672197714 no 691 0.162690060721647 818 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2685 mycophenolic acid 18.85 µM 0.982734944278391 0.191893980659905 no 692 0.162868953752282 822 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2414 st077232 92.9 µM 0.981620283403674 0.192182909373252 no 693 0.163143475510247 757 729801
SGTC_2581 avocatin a 64 µM 0.979658598194112 0.192692039233048 no 694 0.163627334629212 827 6710728 A skin care supplement.
SGTC_35 0133-0054 64.071 µM 0.979653665650302 0.192693320448513 no 695 0.163628552438086 762 99677
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.977343257960897 0.193294015009673 no 696 0.164199622049891 837 688667
SGTC_1004 4084-0029 199 µM 0.97600145331711 0.193643401549416 no 697 0.164531872068695 872 716894 YLR208W SEC13
SGTC_2242 6630449 61.2675 µM 0.973937122100716 0.194181674980805 no 698 0.165043880191013 712 691249 YDR170C SEC7
SGTC_2205 7238770 200 µM 0.973856250456512 0.19420278075913 no 699 0.165063959449122 837 279867
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.968099712040261 0.195708701981599 no 700 0.166497286846174 870 688664
SGTC_2030 5175110 200 µM 0.967409165074882 0.19588982531948 no 701 0.166669765093468 828 2831986
SGTC_1753 st043925 64 µM 0.966772038908587 0.196057027114843 no 702 0.166829002633317 861 670181
SGTC_1019 4262-0212 3.4 µM 0.964821811305246 0.196569365493867 no 703 0.167317034629804 915 4677213
SGTC_1835 st008666 49.2 µM 0.963591928634863 0.19689288091784 no 704 0.167625277518607 719 690455
SGTC_1366 1683-0113 21.9 µM 0.963542185924577 0.196905972305963 no 705 0.16763775211959 811 708623
SGTC_1737 st035557 69.7 µM 0.962812254777498 0.197098137674846 no 706 0.167820874833681 712 5716916
SGTC_1249 0481-0015 10.2 µM 0.961711150199491 0.197388234678603 no 707 0.168097359893913 789 4227577
SGTC_171 k064-0041 9.68 µM 0.960844301359329 0.197616796227657 no 708 0.168315229913561 752 53325
SGTC_506 n9-isopropylolomoucine 153 µM 0.960004515871963 0.197838374489233 no 709 0.168526471075676 858 6610355
SGTC_2010 4012422 159 µM 0.958785128741077 0.198160378112666 no 710 0.168833501212742 841 952393
SGTC_2364 9055074 200 µM 0.958080011588447 0.198346722734181 no 711 0.169011206934262 788 6470630
SGTC_3181 9108277 49.47 µM 0.95778242020632 0.1984254003294 no 712 0.169086242837132 811 17097298
SGTC_744 1594-0068 283 µM 0.955589876770391 0.199005648039394 no 713 0.169639738984514 879 668392
SGTC_1168 k815-0004 80.5 µM 0.953891494380383 0.199455820022159 no 714 0.170069284672064 851 642433
SGTC_1473 k844-0725 134 µM 0.953416300701151 0.199581884176521 no 715 0.170189592784346 930 54682906
SGTC_2994 9053520 71.4286 µM 0.952397122211714 0.199852423745027 no 716 0.170447809196909 845 4647384
SGTC_308 4092-1169 104 µM 0.948513468806908 0.200885354198341 no 717 0.171434059678487 889 2268590 YDL196W YDL196W
SGTC_2382 9035899 200 µM 0.946358964886452 0.201459763850768 no 718 0.171982763896442 864 6462679
SGTC_1233 0325-0408 14.2 µM 0.945541778510202 0.201677890116165 no 719 0.17219117604499 853 12874
SGTC_1311 1190-0148 100 µM 0.94311678062728 0.202326011311969 no 720 0.172810586704311 979 1961333
SGTC_2099 5377090 177.372 µM 0.942248795609346 0.202558297211215 no 721 0.173032638462092 836 2243829
SGTC_927 2425-1185 123 µM 0.942094871037853 0.202599506386455 no 722 0.173072035091785 837 730375
SGTC_1143 3454-2408 5.08 µM 0.941020892552239 0.202887174750759 no 723 0.173347076340517 845 X1143
SGTC_1360 1598-0022 39.8 µM 0.938174703493413 0.203650714180074 no 724 0.174077318074913 940 761525
SGTC_32 0928-0142 34.1 µM 0.933152285578559 0.205002236624707 no 725 0.17537067321083 864 2244242
SGTC_819 1013-0258 27.7 µM 0.929522069402918 0.205982431774733 no 726 0.176309296675685 863 5753198
SGTC_944 3370-0224 231 µM 0.928283676629178 0.206317445200044 no 727 0.176630219557899 872 4580514
SGTC_1289 0976-0073 69.1 µM 0.925895676960705 0.206964364420534 no 728 0.177250099076726 908 3391136
SGTC_1836 st055642 81 µM 0.925458678479351 0.207082878957291 no 729 0.177363684146194 896 8571
SGTC_816 0325-0417 81.3 µM 0.924595354587751 0.20731713145516 no 730 0.177588215172906 865 68101
SGTC_2151 5563267 85.4165 µM 0.923738355146452 0.207549822783415 no 731 0.177811278685597 899 5310824
SGTC_1157 4092-0394 27.6 µM 0.922745955077099 0.207819470662453 no 732 0.178069805583922 951 3659885
SGTC_2445 5742597 35.57 µM 0.921853321172764 0.208062187444766 no 733 0.178302545056809 837 1774255
SGTC_2827 7993847 71.43 µM 0.920322394210974 0.208478852347027 no 734 0.178702154916154 809 2985692
SGTC_720 r052-1644 49.9 µM 0.920155081940425 0.208524418716121 no 735 0.178745861718452 801 1422863 YOR257W CDC31
SGTC_1002 4049-0206 172 µM 0.919589860176943 0.208678396475053 no 736 0.178893563749279 908 4662749
SGTC_691 1548-0686 185 µM 0.917237023424653 0.209320076178824 no 737 0.179509224950019 882 46495133
SGTC_1759 st043059 70 µM 0.917235865414886 0.209320392283815 no 738 0.17950952829121 893 669426
SGTC_596 1155-0152 116 µM 0.916738707994341 0.20945612861117 no 739 0.17963978866734 920 280313
SGTC_175 3793-3120 23.7 µM 0.91630739416228 0.209573929945095 no 740 0.179752845449302 853 5322297
SGTC_2418 pentamidine 31.67 µM 0.915915392567463 0.209681028034657 no 741 0.179855636401081 842 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_16 erodoxin 22.806 µM 0.915520771630086 0.209788874250442 no 742 0.17995915148234 945 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2927 9011802 47.9 µM 0.915407325078332 0.209819884167153 no 743 0.179988917162911 845 43912568
SGTC_1939 st074455 53.6 µM 0.915170763775278 0.209884555410285 no 744 0.180050995173713 906 1644229
SGTC_2958 9077254 16.72 µM 0.913838267283169 0.210249052743122 no 745 0.180400917681517 854 16457351
SGTC_3201 9113999 49.47 µM 0.911176523156787 0.210978270657671 no 746 0.181101185890782 847 16649224
SGTC_294 k038-0071 157 µM 0.910339812461815 0.211207803909027 no 747 0.181321664263519 898 24152826
SGTC_1235 benzylparaben 21.5 µM 0.910311365972972 0.211215610151154 no 748 0.181329163039956 848 7180
SGTC_1924 st058459 75.1 µM 0.909389981443414 0.21146854649292 no 749 0.181572154135471 889 688683
SGTC_2655 perillic acid 100 µM 0.907931272911857 0.211869350255337 no 750 0.181957266881968 866 5702197 An apoptosis inducer.
SGTC_2840 9008771 71.43 µM 0.907819788386468 0.211900000701906 no 751 0.181986720839211 865 2992978
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.906336781927944 0.212307970435602 no 752 0.182378811323344 1105 16725076
SGTC_2375 9072683 200 µM 0.905421366689295 0.212560026835575 no 753 0.182621100216358 995 16798029
SGTC_3141 9094609 49.47 µM 0.900505731468607 0.213916515915998 no 754 0.183925588288443 826 25236309 YDL196W YDL196W
SGTC_1752 st044819 83.042 µM 0.899379151859415 0.214228108446433 no 755 0.184225370030817 863 441209 YML126C ERG13
SGTC_1872 amphotericin b 148 nM 0.899227756540838 0.21427000190291 no 756 0.18426567934385 953 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2916 7875993 68.79 µM 0.899202692900089 0.214276937864724 no 757 0.184272353118916 899 1299250
SGTC_2830 7992007 71.43 µM 0.897331713677247 0.214795070110295 no 758 0.184770969326002 862 1952075
SGTC_248 streptozotocin 5.23457 mM 0.895727870739139 0.21523980288889 no 759 0.185199060619907 959 5300 DNA alkylating agent.
SGTC_2820 7989630 71.43 µM 0.89474491139734 0.2155126335583 no 760 0.185461732360716 801 2984098
SGTC_2354 9060492 162 µM 0.894220589305678 0.21565824664438 no 761 0.185601939086102 970 6471895
SGTC_667 1498-1044 59 µM 0.893796197115975 0.215776149271611 no 762 0.185715472133966 947 6739982
SGTC_1275 0867-0008 21.1 µM 0.893293027044935 0.215915985993572 no 763 0.185850135584136 921 3422836
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.892901756106948 0.216024760948577 no 764 0.185954893303168 975 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_883 0850-0245 24.6 µM 0.892708687497684 0.216078446522728 no 765 0.186006598407092 947 6823229 YPR165W RHO1
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.890881297237985 0.21658696191219 no 766 0.186496427443296 858 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1704 st028805 70.8 µM 0.889009244283729 0.217108622956596 no 767 0.186999055822403 903 2876101
SGTC_2297 7971671 152.32 µM 0.885837372608506 0.217994142832353 no 768 0.187852583901104 918 909016
SGTC_582 0987-0078 156 µM 0.884913528813435 0.218252451638848 no 769 0.188101635380373 1042 1625765
SGTC_815 1582-0027 36.9 µM 0.883715310532329 0.21858773872779 no 770 0.18842495663458 938 3128206
SGTC_1714 st033236 13.627 µM 0.883235302268954 0.218722138448278 no 771 0.188554575776796 946 2916566
SGTC_2743 auranofin 4.32 µM 0.882893613225834 0.218817838504526 no 772 0.188646877345795 912 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2263 7948595 193.29 µM 0.882829560729102 0.21883578096948 no 773 0.188664183154085 868 2971371
SGTC_2899 9053889 58.44 µM 0.87890265696508 0.219937405852484 no 774 0.18972702896826 938 6470052
SGTC_900 1112-0045 141 µM 0.877760537675739 0.22025840401308 no 775 0.190036842032876 834 56211 YIL048W NEO1
SGTC_756 0508-1999 28.3 µM 0.877268743865422 0.220396707743175 no 776 0.190170342507895 884 6753853
SGTC_2508 celastrol 40.54 µM 0.876771479874866 0.220536600411453 no 777 0.190305386471168 888 122724 Celastrol is a natural product and antioxidant.
SGTC_1321 1326-2144 215 µM 0.876728194268198 0.220548780130691 no 778 0.190317144502193 954 3513030
SGTC_1900 st060200 72.8 µM 0.873407065210074 0.221484429175093 no 779 0.191220620697667 927 688945
SGTC_1170 0310-0127 64.8 µM 0.872977850368949 0.22160551559973 no 780 0.191337575378861 955 774975
SGTC_2402 5553605 200 µM 0.871841243535576 0.221926348086956 no 781 0.1916474955916 970 6758546
SGTC_544 k015-0020 52.4 µM 0.871229489120351 0.222099139081539 no 782 0.19181443074522 918 3008304
SGTC_2295 7971645 200 µM 0.870334399973572 0.222352096742481 no 783 0.192058842465118 913 2978226 YKL099C UTP11
SGTC_803 4488-1585 147 µM 0.867034034990177 0.223286218952977 no 784 0.192961680851184 943 747204
SGTC_1215 3852-0577 11.2 µM 0.866545306223602 0.223424736414644 no 785 0.193095596077965 1019 2884876
SGTC_2400 5203494 178.7 µM 0.865693629479232 0.223666238837265 no 786 0.193329097236749 886 6777674
SGTC_523 1934-0222 13.7 µM 0.864247977279992 0.224076509224069 no 787 0.193725840764931 921 1361595
SGTC_1403 3909-7815 62.9 µM 0.863884655883458 0.224179685578068 no 788 0.193825628372017 917 6615483
SGTC_632 0781-2353 4.65 µM 0.862471662952451 0.224581205038826 no 789 0.194214010048347 978 6811515 YHR007C ERG11
SGTC_2105 5350118 200 µM 0.862408139294942 0.224599265651723 no 790 0.194231481576109 967 2133313
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.859255975478254 0.225496501607671 no 791 0.195099653588509 982 688751
SGTC_1423 4048-0112 5.59 µM 0.859211831282315 0.225509081256557 no 792 0.195111828549593 986 X1423
SGTC_1133 3473-0247 50 µM 0.858677137502394 0.225661482997241 no 793 0.195259333665469 885 711311
SGTC_3100 9120536 49.47 µM 0.856581620265838 0.226259321719032 no 794 0.19583807349697 862 16421196
SGTC_3351 9150312 21.596 µM 0.856252879307563 0.226353190707467 no 795 0.195928959525924 939 4904905
SGTC_1446 4239-0190 62 µM 0.853021718717116 0.227276988953684 no 796 0.196823630085533 988 1340085
SGTC_1242 0402-0103 60.1 µM 0.851259914364903 0.227781587646023 no 797 0.197312493536334 917 432868
SGTC_1455 4262-0120 131 µM 0.849483380596737 0.2282910428031 no 798 0.197806187038909 1004 1529587
SGTC_2593 nobiletin 86.24 µM 0.849274909673557 0.228350867800171 no 799 0.197864169384308 906 72344 An anti-infammatory.
SGTC_2918 7977171 22.06 µM 0.848917875848506 0.228453346424594 no 800 0.197963495610666 959 2236483
SGTC_2380 9035439 200 µM 0.847669237634175 0.228811943398187 no 801 0.198311101479554 1033 6462575
SGTC_1241 0364-0022 50.8 µM 0.846610947092862 0.229116121560401 no 802 0.198606005065027 973 4563895
SGTC_2782 7736369 71.43 µM 0.845191755252904 0.229524387226768 no 803 0.199001892437065 995 2950836 YOL077C BRX1
SGTC_3093 9117344 49.47 µM 0.844018873593381 0.229862103095071 no 804 0.199329429539433 926 24824913
SGTC_469 w7 172 µM 0.842431824643647 0.230319515554495 no 805 0.199773142783024 984 45115570 A P450 inhibitor.
SGTC_2377 9073351 62.6 µM 0.84225157927988 0.230371497269037 no 806 0.199823574019259 946 7337946 YHR072W ERG7
SGTC_327 1273-0057 3.96 µM 0.841083231297498 0.230708601047133 no 807 0.200150654248049 952 3108138
SGTC_1824 st053723 68.6 µM 0.840590804095488 0.230850763714198 no 808 0.200288606090316 1016 675225
SGTC_1493 4348-0038 111 µM 0.837277539775285 0.231808566796643 no 809 0.201218290552637 1057 800424
SGTC_3194 9111903 49.47 µM 0.836017530554621 0.232173392210579 no 810 0.201572520480422 974 17087251
SGTC_1035 k081-0041 55.2 µM 0.829880223600996 0.233954960739485 no 811 0.203303253638214 1033 731709
SGTC_1339 1486-1321 22.7 µM 0.827384324028083 0.234681643610846 no 812 0.204009631391932 982 3469382
SGTC_2536 dehydroabietamide 32.04 µM 0.826382882883653 0.234973564361847 no 813 0.204293465117317 1027 3983547
SGTC_1055 3448-0672 86 µM 0.825389743807105 0.235263263092919 no 814 0.204575177903617 956 748378
SGTC_1379 2144-0755 36.5 µM 0.823147663988039 0.235918002446737 no 815 0.205212013260835 1068 5392327
SGTC_950 1165-0508 94.1 µM 0.82296664618095 0.235970907628975 no 816 0.205263480492882 949 6148369
SGTC_2336 9001819 198.65 µM 0.821576783952416 0.236377333558911 no 817 0.205658903445862 1030 2989602
SGTC_616 4092-0450 108 µM 0.820009122299241 0.236836213996939 no 818 0.206105453408581 1031 787165
SGTC_2022 5136654 200 µM 0.819440250793741 0.237002853119033 no 819 0.206267639074517 982 1713771
SGTC_2872 9044037 25.97 µM 0.817939581504621 0.237442752154607 no 820 0.206695843763597 1021 6465195
SGTC_448 monastrol 171 µM 0.817736409164063 0.237502343557012 no 821 0.206753857891189 1027 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2673 kobusone 100 µM 0.817568072267131 0.237551723777913 no 822 0.206801932357167 1040 6710676 An epoxy ketone and protein crosslinker.
SGTC_1220 1838-0075 193 µM 0.815712570651069 0.238096392838627 no 823 0.207332273817116 995 5529645
SGTC_735 3076-0345 636 µM 0.813698286481882 0.238688445304441 no 824 0.207908908020496 1050 2888990
SGTC_1436 4092-1007 8.32 µM 0.813011144909856 0.238890598873463 no 825 0.208105834184639 1011 2881121
SGTC_3327 9140648 26.9345 µM 0.812108207311223 0.239156380836938 no 826 0.208364772090736 1020 8029710
SGTC_568 1193-0097 7.48 µM 0.810905154479621 0.23951075342963 no 827 0.208710069993664 992 3646150
SGTC_68 0986-0284 82.829 µM 0.810182943936142 0.239723626213672 no 828 0.208917519369771 855 423278 YIL048W NEO1
SGTC_2768 sulfasalazine 50.2 µM 0.809413211465724 0.239950619774007 no 829 0.209138752715704 1048 5384001 An antioxidant and salicylic acid derivative.
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.80935823349894 0.239966837221364 no 830 0.209154559533355 955 2374 Ca(2+)-ATPase inhibitor.
SGTC_113 0099-0221 2.5 µM 0.809294951394754 0.239985504970171 no 831 0.209172754759774 992 89219
SGTC_2047 4141938 200 µM 0.808994435272672 0.240074165793599 no 832 0.209259173564681 978 3807862
SGTC_287 k060-0039 29.6 µM 0.806820360984049 0.240716111268145 no 833 0.209884993355098 1050 5861974
SGTC_2427 5545055 42.75 µM 0.806474031740754 0.240818459141849 no 834 0.209984787699078 1066 5372858
SGTC_686 1319-0111 510 µM 0.805714196128789 0.241043090134094 no 835 0.210203831060581 1060 4562600
SGTC_2384 9036245 200 µM 0.805488632353741 0.241109795712583 no 836 0.210268881800654 1047 6462766
SGTC_3309 9129340 25.759 µM 0.80393745186145 0.241568795295151 no 837 0.210716549591638 1064 17158987
SGTC_2843 9000894 45.46 µM 0.803192666896418 0.241789348181242 no 838 0.210931691660532 923 2242070
SGTC_2421 5690543 90.72 µM 0.802688820452756 0.241938613981132 no 839 0.211077308107668 1015 3397993
SGTC_2456 5770359 74.46 µM 0.802630580488618 0.24195587094208 no 840 0.211094143813152 1065 3118787
SGTC_604 1000-0114 314 µM 0.801258220197767 0.242362705296263 no 841 0.211491086301527 1083 1572745
SGTC_2803 7707263 71.43 µM 0.800874031662053 0.24247666383946 no 842 0.211602287527429 997 2199229
SGTC_890 0929-0006 47.2 µM 0.800556353575718 0.242570915877967 no 843 0.211694263522363 1008 1378169
SGTC_154 3389-1638 511.116 µM 0.798167082316545 0.243280425050367 no 844 0.212386768543528 994 5238686
SGTC_1848 st056003 16.4 µM 0.797428915926246 0.24349985480875 no 845 0.212600985623901 1134 146492
SGTC_1159 4092-0538 61.2 µM 0.794768162423627 0.244291685563894 no 846 0.213374187017762 1105 717301
SGTC_3180 9109287 49.47 µM 0.793689952482364 0.244612951733543 no 847 0.213687975468244 999 18891271
SGTC_530 4358-1714 28 µM 0.793482637983045 0.244674749758551 no 848 0.213748340429369 1058 1564641
SGTC_1101 ebselen 5.29 µM 0.79257422677516 0.24494563560013 no 849 0.214012964853944 1131 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_178 4092-0806 87.505 µM 0.79148175497204 0.245271621437736 no 850 0.2143314594144 1038 2169044
SGTC_1314 1222-0010 41.1 µM 0.79135756995861 0.245308692122123 no 851 0.214367681224374 1038 3526027
SGTC_2946 9065502 71.43 µM 0.790341090504899 0.245612236357074 no 852 0.214664297866915 891 16489101
SGTC_1454 4239-0054 42.6 µM 0.789565586000817 0.245843955504987 no 853 0.214890756458509 1099 1340767
SGTC_455 paf C-16 10 µM 0.78543918237688 0.24707888721264 no 854 0.21609805762691 1026 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_45 0kpi-0036 14.9 µM 0.781820353001754 0.248164639587464 no 855 0.217160078998271 1033 2795021
SGTC_3301 9125354 19.7965 µM 0.780865975443005 0.248451403621619 no 856 0.217440662743934 1002 41905162
SGTC_457 grayanotoxin iii 135 µM 0.780612933916074 0.248527465201799 no 857 0.217515091176801 1067 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1920 st075728 45.7 µM 0.780490631779245 0.248564232364721 no 858 0.217551069817134 1043 3400306
SGTC_2664 lyso-paf C-16 73.48 µM 0.780371192990365 0.248600141528382 no 859 0.21758620943736 1092 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2726 cimetidine 79.27 µM 0.7797938094618 0.248773770325101 no 860 0.217756125377826 1090 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_408 cantharidin 100 µM 0.779521720731979 0.248855614293163 no 861 0.217836223833661 1046 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2776 terbinafine 19.92 µM 0.778661497626306 0.249114462648243 no 862 0.218089571157239 1093 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_245 methotrexate 289.6 µM 0.77827110030041 0.249231983712456 no 863 0.218204604448977 1068 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3318 9139014 38.6185 µM 0.777732781686547 0.249394081771548 no 864 0.218363281110422 1036 16643984
SGTC_1038 k292-0204 154 µM 0.776661646338184 0.249716787778315 no 865 0.218679210308348 1040 4454212
SGTC_2064 5220758 200 µM 0.775901527304154 0.249945926876371 no 866 0.218903565382872 1111 788518
SGTC_1039 k821-0043 94 µM 0.775344270204524 0.25011398378262 no 867 0.219068128260791 1094 15992768
SGTC_1464 k208-0027 110 µM 0.772803008838764 0.250881133561694 no 868 0.219819486231313 1066 X1464
SGTC_1121 fusaric acid 630.51 nM 0.771543531286021 0.251261802670464 no 869 0.220192415186893 1043 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.768176485715395 0.252280968582767 no 870 0.221191170694538 1061 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2298 7976326 193.81 µM 0.765654071538328 0.253045899936078 no 871 0.221941080968009 1009 2235818
SGTC_2070 5230947 200 µM 0.765155769519484 0.253197156059042 no 872 0.222089397018485 1177 2835538
SGTC_2006 4011487 200 µM 0.764641607309517 0.253353276259323 no 873 0.222242493031362 1109 45595294
SGTC_2235 salicylic acid 500 µM 0.763991574480062 0.253550724612497 no 874 0.222436131799295 1111 338 A COX inhibitor and kinase inhibitor.
SGTC_658 3253-0951 102 µM 0.763574694759655 0.253677394927364 no 875 0.222560367039316 1127 1184878
SGTC_397 arbidol 50 µM 0.763015282236973 0.253847426523642 no 876 0.222727140940182 1112 131410 A RNA synthesis inhibitor.
SGTC_3228 9131799 49.47 µM 0.759806709658188 0.254823815982954 no 877 0.223685065830081 1042 17015818
SGTC_1343 1487-0095 224 µM 0.757936862970389 0.255393727782187 no 878 0.224244390400952 1102 4560101 YGL055W OLE1
SGTC_1840 st055363 71 µM 0.756210639181124 0.255920455392954 no 879 0.224761457474673 1055 676033
SGTC_896 0964-0007 44.5 µM 0.756052499164714 0.255968737437769 no 880 0.224808859967177 1119 6756758
SGTC_2775 cyproheptadine 69.59 µM 0.754515050552198 0.256438386537981 no 881 0.225270005743475 1138 2913 A selective serotonin reuptake inhibitor.
SGTC_2447 5741742 33.78 µM 0.751877456285581 0.257245145093819 no 882 0.226062378205285 1107 1776504
SGTC_134 0269-0018 6.916 µM 0.750105141951932 0.257787981452448 no 883 0.226595691447861 1027 4378915
SGTC_193 1273-0060 1.558 µM 0.749964476879808 0.257831090748816 no 884 0.226638049860565 995 2847393 YHR072W ERG7
SGTC_2314 7727897 200 µM 0.749958465925877 0.257832932995186 no 885 0.226639860036102 1122 900724
SGTC_3074 9116018 49.47 µM 0.748492849538147 0.258282321152247 no 886 0.227081468234443 1143 17027303
SGTC_1893 st059353 36.1 µM 0.747980420772093 0.258439538084095 no 887 0.227235983691834 1090 3112488
SGTC_1187 1391-0724 117 µM 0.747225011657691 0.258671393558901 no 888 0.22746387436756 1126 6997986
SGTC_605 1315-0399 119 µM 0.74676501203913 0.258812632607351 no 889 0.227602709391389 1143 24020461
SGTC_1515 3460-0031 42.1 µM 0.746477962913831 0.258900788865555 no 890 0.227689369443002 1057 2876596
SGTC_2692 st077426 47.7 µM 0.745810176638766 0.259105934197632 no 891 0.227891045785384 1134 25238571
SGTC_325 2810-4341 181 µM 0.744646918624007 0.259463490087249 no 892 0.228242598133623 1132 774970
SGTC_2130 NSC 7 2.4545 µM 0.743984861000636 0.259667103476861 no 893 0.228442816976607 1127 21448
SGTC_1043 0916-0009 19.3 µM 0.743970390861736 0.259671554635779 no 894 0.22844719412409 1190 3101130
SGTC_1266 0828-0227 32.9 µM 0.743369285551839 0.259856495413445 no 895 0.228629067223806 1079 3913820
SGTC_1981 st071826 47 µM 0.742267188003871 0.260195751816083 no 896 0.228962733887751 1090 11838600
SGTC_20 0481-0013 4.944 µM 0.741948084241808 0.260294023464226 no 897 0.22905939545844 1125 182045
SGTC_1989 st071868 50.2 µM 0.741778918235948 0.260346127822879 no 898 0.229110647797389 1141 16414057
SGTC_2558 carylophyllene oxide 100 µM 0.74172165498136 0.26036376653843 no 899 0.229127998341378 1216 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2565 isoliquiritigenin 100 µM 0.741413226774109 0.260458781808872 no 900 0.229221463565355 1057 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_741 4582-0002 126 µM 0.741186567853324 0.260528618381896 no 901 0.229290163279127 1100 2912688
SGTC_846 0335-0850 148 µM 0.739301957007881 0.261109664721768 no 902 0.229861830617767 1115 6819598
SGTC_3163 9099914 49.47 µM 0.738732306206341 0.261285425360406 no 903 0.230034782227781 1123 16268368
SGTC_2605 digitonin 300 nM 0.737649762889096 0.261619601801136 no 904 0.230363653668872 1195 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1670 st016595 4.04 µM 0.737577510335094 0.261641913658446 no 905 0.230385613001023 1148 597879
SGTC_2749 bexarotene 57.39 µM 0.735293787846435 0.262347638533331 no 906 0.231080295354528 1127 82146 An retinoic acid receptor inhibitor.
SGTC_1393 3470-5649 58.2 µM 0.734693258299237 0.262533378275822 no 907 0.231263163534461 1041 4108395
SGTC_1260 0700-1617 7.75 µM 0.734192153739446 0.262688418039005 no 908 0.231415817424043 1126 2853078
SGTC_2797 7859098 81.82 µM 0.730551139909957 0.263816338248356 no 909 0.232526682726743 1171 972681
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.730366210007621 0.263873692013667 no 910 0.232583183446391 1137 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2274 7947094 46.08 µM 0.730173804735673 0.263933370920701 no 911 0.23264197617964 1167 2971028
SGTC_2507 purpurin 79.67 µM 0.7298729302892 0.264026707818273 no 912 0.232733930088684 1160 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_3295 9122362 53.5725 µM 0.728494972794208 0.264454390888913 no 913 0.233155322468344 1144 4730473
SGTC_2607 solasodine 47.35 µM 0.728003704432586 0.264606953344619 no 914 0.23330565931974 1147 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3114 9122766 49.47 µM 0.727436033581773 0.264783298187778 no 915 0.233479443662199 1086 17176985
SGTC_2641 levomentholum 100 µM 0.727070610162475 0.264896847220065 no 916 0.233591350811257 1119 16666
SGTC_44 0929-0055 61.211 µM 0.726544629768793 0.265060330003196 no 917 0.233752479078833 1113 1379590
SGTC_3036 9090181 49.47 µM 0.725194693691253 0.26548014531273 no 918 0.234166298860184 1140 25236586
SGTC_2912 7964298 10.93 µM 0.725181999250691 0.265484094744985 no 919 0.234170192235782 1190 2975850
SGTC_584 0986-0246 15.4 µM 0.725079852368147 0.265515875268363 no 920 0.234201521914157 1250 53315 YDR232W HEM1
SGTC_666 0272-0154 136 µM 0.72477642588688 0.265610290433736 no 921 0.234294600151974 1168 6870312
SGTC_526 4469-0568 170 µM 0.722866539234006 0.266204967566161 no 922 0.234880941309564 1177 2901964
SGTC_1180 1193-0155 285 µM 0.722749018974732 0.266241581587644 no 923 0.234917046862044 1144 2921347
SGTC_2393 9031399 185.94 µM 0.721950526690519 0.2664904233138 no 924 0.235162447507304 1172 1526623 YDL150W RPC53
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.721854985104616 0.266520205722868 no 925 0.235191819784568 1177 165506
SGTC_3155 9099265 49.47 µM 0.721027343104972 0.266778270331047 no 926 0.235446345906209 1086 25236499
SGTC_2875 9039966 71.43 µM 0.71940596616995 0.26728419283347 no 927 0.235945410945428 1195 6463691
SGTC_2689 tacrolimus 100 µM 0.719074075602729 0.267387813178926 no 928 0.236047639767926 1154 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2369 9071472 200 µM 0.718180924371052 0.267666766659482 no 929 0.236322869084263 1164 17296037
SGTC_740 k014-0057 261 µM 0.718173046115702 0.267669227888223 no 930 0.236325297596575 1170 4012779
SGTC_1628 st004252 77.7 µM 0.716939285455387 0.268054805096629 no 931 0.236705780118514 1143 692968
SGTC_970 1315-0089 19.5 µM 0.715494476624877 0.268506694640558 no 932 0.237151776308192 1133 6811083 YLR033W RSC58
SGTC_510 ag-490 170 µM 0.714809203991693 0.268721159607585 no 933 0.237363473548801 1261 5328779
SGTC_427 1354-0053 47.3 µM 0.71295835867917 0.269300835453719 no 934 0.237935762549394 1178 6813657
SGTC_1979 st071809 45.3 µM 0.708761390905998 0.270617624576632 no 935 0.239236280396034 1196 4976333
SGTC_1361 1608-0041 5.61 µM 0.707614278554542 0.270978087256874 no 936 0.239592411701923 1174 X1361
SGTC_2067 5224629 34.075 µM 0.705703358209962 0.271579096432775 no 937 0.240186316069236 1180 2835000
SGTC_2930 9013230 14.89 µM 0.703651714359411 0.272225103033641 no 938 0.240824848708322 1163 2995857
SGTC_2363 9053361 176 µM 0.703048558692184 0.272415165428166 no 939 0.241012744229489 1209 6469797 YMR079W SEC14
SGTC_710 3448-4187 58 µM 0.702823175118549 0.272486203709578 no 940 0.241082976350573 1206 3946412
SGTC_2229 7354935 190 µM 0.701449932315686 0.272919232539191 no 941 0.2415111349936 1148 318112
SGTC_3168 9103419 49.47 µM 0.700641177902505 0.273174419100019 no 942 0.241763486837672 1144 16649256
SGTC_431 k089-0097 107 µM 0.700587039095388 0.273191505757754 no 943 0.24178038462444 1164 5499420
SGTC_1444 4112-3581 28 µM 0.700526729744746 0.273210540513819 no 944 0.2417992091139 1208 2877249
SGTC_372 0155-0182 15.9 µM 0.699450771757121 0.273550243316088 no 945 0.242135183865 1186 771486
SGTC_1025 k007-0731 70 µM 0.699111394405114 0.273657435307862 no 946 0.242241209093323 1182 6256118
SGTC_33 0986-0033 35.816 µM 0.699059389839609 0.273673862733025 no 947 0.242257458116371 1141 2848082
SGTC_822 1487-0950 154 µM 0.69874104828091 0.27377443246201 no 948 0.242356938014695 1194 1958375
SGTC_672 1441-0018 53.7 µM 0.698583208767194 0.273824303533123 no 949 0.24240627015798 1163 251141
SGTC_736 0958-0254 92.6 µM 0.698447242510605 0.27386726711751 no 950 0.242448770258785 1214 6812352
SGTC_2718 lomofungin 53.02 µM 0.697804356943218 0.274070455793926 no 951 0.242649776987462 1220 5351222 A RNA synthesis inhibitor.
SGTC_1244 0416-0015 52.5 µM 0.696703315061927 0.274418621051484 no 952 0.242994241874296 1190 96201
SGTC_2417 cerulenin 830 nM 0.69552574111324 0.274791228270974 no 953 0.243362942626083 1236 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1959 st077091 55.8 µM 0.695215417802883 0.274889462088082 no 954 0.243460155780321 1208 821356 YKL052C ASK1
SGTC_580 1123-0028 41 µM 0.694850209438669 0.275005092105314 no 955 0.243574589319369 1258 1677248 YPR107C YTH1
SGTC_3148 9097893 49.47 µM 0.693807258606161 0.275335436622367 no 956 0.243901544978042 1145 17174100
SGTC_366 0181-0206 4.31 µM 0.693707488689405 0.275367048002908 no 957 0.243932834351145 1210 274874
SGTC_2938 9059746 27.26 µM 0.691368101444305 0.276108777488378 no 958 0.244667122380586 1149 6471769
SGTC_2307 7538926 6.34 µM 0.690087252664153 0.276515300345075 no 959 0.245069659500411 1214 96582
SGTC_742 0kpi-0133 140 µM 0.689505361397182 0.276700081098666 no 960 0.245252650247749 1208 2728852
SGTC_3257 9139206 32.98 µM 0.689047548385945 0.276845503064831 no 961 0.245396672997995 1173 4910041
SGTC_3183 9108214 49.47 µM 0.687543240963142 0.2773236020417 no 962 0.245870230823673 1109 4974831
SGTC_825 1988-2224 89.6 µM 0.687341431408062 0.277387771856449 no 963 0.245933798012556 1206 1180859
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.686087197604573 0.277786745935205 no 964 0.246329061779817 1221 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_975 1335-0046 28.5 µM 0.683740666611842 0.278533933425837 no 965 0.247069469598714 1203 16486740
SGTC_2086 5274770 176.623 µM 0.683222419890237 0.278699086559072 no 966 0.24723315386657 1215 689278
SGTC_382 3229-0966 23.2 µM 0.683108293883379 0.278735462257914 no 967 0.247269207482986 1229 5722370
SGTC_3322 9139058 2.11 µM 0.682855375955872 0.278816083726088 no 968 0.247349116956338 1253 4908926 YPR165W RHO1
SGTC_232 clozapine 119 µM 0.681339326396175 0.279299585527506 no 969 0.247828402370473 1176 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2812 7970281 58.44 µM 0.680808601405414 0.279468941711473 no 970 0.24799630337841 1238 2233435
SGTC_1657 st012939 43.4 µM 0.678124198738013 0.280326307133107 no 971 0.248846474392845 1243 24207257
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.677602981678664 0.280492925051316 no 972 0.24901172753826 1250 364106
SGTC_2627 acetyl isogambogic acid 100 µM 0.676552059148432 0.280829020073875 no 973 0.249345102582491 1193 6857789 A caspase activator and apoptosis inducer.
SGTC_363 0455-0021 3.06 µM 0.676551570705958 0.280829176327683 no 974 0.249345257582007 1245 4597466
SGTC_1986 st071812 45 µM 0.674669385705959 0.281431603353001 no 975 0.249942919501718 1200 11838594
SGTC_3086 9117350 49.47 µM 0.673801264076228 0.281709671214181 no 976 0.250218835549368 1167 2679265
SGTC_3121 9125696 49.47 µM 0.673334884518991 0.281859111827401 no 977 0.250367132144506 1281 1235365
SGTC_2908 7930301 100 µM 0.67288139616416 0.282004458371301 no 978 0.250511374335487 1198 2223178
SGTC_196 k015-0023 18.111 µM 0.670052086310403 0.282912088430877 no 979 0.251412293543467 1228 5211998
SGTC_1200 1643-0193 18.4 µM 0.669239290363858 0.283173088895517 no 980 0.251671423284639 1234 5403974
SGTC_2699 st077704 54.6 µM 0.667368311838252 0.283774325642628 no 981 0.252268450828538 1242 645852
SGTC_1164 k060-0068 93.7 µM 0.666476746602465 0.284061043954394 no 982 0.252553210973229 1271 5963676
SGTC_3305 9127027 53.8275 µM 0.666240306069871 0.284137104066487 no 983 0.252628756943687 1180 41905295
SGTC_257 daunorubicin 18.5 µM 0.665545287392806 0.284360739699462 no 984 0.252850893778694 1284 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1565 sinapyl alcohol 95.1 µM 0.665369179284838 0.284417419226105 no 985 0.252907196499318 1222 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2859 9028643 45.46 µM 0.665301872215057 0.284439083100458 no 986 0.252928716678588 1213 17151580
SGTC_601 0986-0029 62.9 µM 0.665008928199946 0.284533381074319 no 987 0.253022391283558 1244 24747981
SGTC_1336 1486-0901 104 µM 0.664641925350905 0.284651539474463 no 988 0.253139773409983 1258 5006114
SGTC_1424 4048-1941 275 µM 0.662793501614437 0.285247004562498 no 989 0.25373140806412 1297 X1424
SGTC_3075 9116269 49.47 µM 0.66270040710669 0.285277010417505 no 990 0.253761224503348 1265 17015205 YNL244C SUI1
SGTC_2799 7812892 81.82 µM 0.66014581206878 0.286100983648258 no 991 0.254580131107644 1244 20205235
SGTC_3173 9105693 49.47 µM 0.660033577336353 0.286137210374734 no 992 0.254616141038853 1300 17096658
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.65968813475596 0.286248724770988 no 993 0.25472699123726 1235 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3236 9132701 49.47 µM 0.657569500591829 0.286933104829254 no 994 0.255407399020047 1223 24282524
SGTC_1428 4049-0204 61.7 µM 0.656640546217462 0.28723342821057 no 995 0.255706035654645 1303 X1428
SGTC_3206 9114350 49.47 µM 0.656074318890018 0.287416557839631 no 996 0.255888153604942 1214 17087243
SGTC_2756 carbadox 75.1 µM 0.655188290824269 0.287703228409802 no 997 0.256173266114063 1265 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2602 kawain 100 µM 0.653991954231605 0.28809051220316 no 998 0.256558494606606 1239 5369129
SGTC_2583 asiatic acid 100 µM 0.653780794744666 0.288158895296171 no 999 0.256626520708342 1277 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1482 3346-2049 8.48 µM 0.65356591366458 0.288228491471933 no 1000 0.256695755381748 1266 3826804
SGTC_2254 7938975 95.19 µM 0.650751853068413 0.289140646813138 no 1001 0.257603342394949 1333 2969277
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.649751414517996 0.289465257751729 no 1002 0.257926403531437 1310 1377
SGTC_904 1141-0088 396 µM 0.649729967987278 0.289472218352087 no 1003 0.257933331335425 1204 1378119
SGTC_36 0335-0881 14.2 µM 0.648949298527808 0.289725642810338 no 1004 0.258185574183269 1224 23828853
SGTC_172 1112-0046 2.638 µM 0.643670721990437 0.291441924136684 no 1005 0.259894489655044 1248 2802135 YIL048W NEO1
SGTC_1412 3909-8563 178 µM 0.640668918676416 0.2924200440118 no 1006 0.260868906026931 1346 23767530
SGTC_358 0075-0058 9.45 µM 0.640633351251749 0.292431642590146 no 1007 0.260880462835039 1308 1069125
SGTC_3220 9131269 49.47 µM 0.639724541380736 0.292728079062735 no 1008 0.261175848787399 1313 17722206
SGTC_987 1497-1013 404 µM 0.639283080096391 0.292872125667219 no 1009 0.261319396751656 1271 1676435
SGTC_1054 3429-0080 167 µM 0.638846114088089 0.293014737878035 no 1010 0.26146152290831 1300 1162877
SGTC_2024 5144227 134 µM 0.637855350566259 0.293338211776667 no 1011 0.26178392241931 1280 3475211
SGTC_2990 9074105 71.4286 µM 0.635140993498791 0.294225267513082 no 1012 0.262668231569967 1259 6502001
SGTC_964 1287-0107 19.4 µM 0.6349735893807 0.294280015962547 no 1013 0.262722820075677 1331 51516812 YPR165W RHO1
SGTC_1814 st052110 31.539 µM 0.634923054319798 0.294296544056558 no 1014 0.262739300102493 1267 674163
SGTC_1769 st044406 64.4 µM 0.634773844959414 0.294345347257885 no 1015 0.262787961964982 1291 670903
SGTC_1916 st067606 49.2 µM 0.634733269144052 0.294358619388485 no 1016 0.262801195810946 1322 19590279
SGTC_2179 6298986 200 µM 0.631067765465967 0.295558724168442 no 1017 0.263998108346178 1288 738374
SGTC_1151 3909-8316 15.3 µM 0.630072327982302 0.295885023530104 no 1018 0.264323631786591 1295 800431
SGTC_1740 st038286 13.222 µM 0.62938490654351 0.296110453319901 no 1019 0.264548548448343 1325 716786
SGTC_2313 7726885 200 µM 0.628892713864259 0.29627190909909 no 1020 0.264709648224991 1296 726423
SGTC_1614 st002383 48.6 µM 0.627867830302878 0.296608234928323 no 1021 0.26504526328337 1303 1947235
SGTC_3267 9137951 49.47 µM 0.62780477057063 0.296628934322594 no 1022 0.26506592029204 1326 16643986
SGTC_183 3914-0051 30.55 µM 0.627267574929573 0.296805295928087 no 1023 0.265241927154561 1296 1596232
SGTC_2398 5228213 48.84 µM 0.625986414150015 0.297226095279102 no 1024 0.265661926240572 1320 80771 YMR134W ERG29
SGTC_3112 9123419 49.47 µM 0.62545527364902 0.297400629162606 no 1025 0.265836147266248 1332 17015854
SGTC_728 3030-5151 22.5 µM 0.625225142507927 0.297476265271228 no 1026 0.265911651263805 1329 3125388
SGTC_3134 9127454 49.47 µM 0.624917947070453 0.297577243422176 no 1027 0.266012456307953 1385 24262820
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.624779734495403 0.297622680352966 no 1028 0.266057816565093 1295 16486 A toxic proline analog.
SGTC_1414 3917-0015 5.4 µM 0.622692317649859 0.298309296472878 no 1029 0.266743366034767 1289 6618702
SGTC_1238 0333-0287 48.8 µM 0.622182460930921 0.298477113674995 no 1030 0.266910948749949 1308 7226
SGTC_2798 7813637 45.45 µM 0.620855781696113 0.298913985751898 no 1031 0.267347258617255 1310 956368
SGTC_774 k060-0086 136 µM 0.620199078609747 0.299130343821231 no 1032 0.267563364028346 1324 5911235
SGTC_554 4483-2211 187 µM 0.620191644250814 0.299132793559581 no 1033 0.267565811003613 1304 747107
SGTC_2748 diazoxide 86.69 µM 0.618493212234322 0.299692692162402 no 1034 0.268125135406601 1296 3019 A potassium channel activatior.
SGTC_2448 5185112 27.17 µM 0.618226005843726 0.299780821599043 no 1035 0.268213184850589 1296 5718189
SGTC_17 0960-0276 49.807 µM 0.618186337930652 0.299793905785107 no 1036 0.268226257401182 1304 6821114
SGTC_2819 7996655 46.38 µM 0.615026318929579 0.30083704578338 no 1037 0.269268669722981 1252 6456960
SGTC_2249 haloperidol 116.36 µM 0.61431483029264 0.301072137803392 no 1038 0.269503652199382 1317 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3285 9112818 20.8695 µM 0.612082426438613 0.301810311662269 no 1039 0.270241611964 1342 17017947 YPR165W RHO1
SGTC_2126 5251174 33.877 µM 0.61160868854808 0.30196706393183 no 1040 0.270398344092934 1387 790722
SGTC_2145 5634607 200 µM 0.611482740933034 0.302008744130551 no 1041 0.270440020427557 1285 308662
SGTC_1153 4055-0057 267 µM 0.611238560247873 0.302089558891869 no 1042 0.270520829481007 1298 882706
SGTC_1970 st070122 35.8 µM 0.61073312360144 0.302256870540716 no 1043 0.270688136792963 1358 102928
SGTC_2157 5649910 96.377 µM 0.609906487296046 0.302530596551254 no 1044 0.270961877446698 1297 2858091
SGTC_995 3931-2021 34.6 µM 0.609726128570133 0.302590333921488 no 1045 0.271021621597448 1338 730143
SGTC_2299 7976368 114.88 µM 0.609581161096627 0.302638353038378 no 1046 0.271069647095512 1377 2979718
SGTC_2954 9074818 52.69 µM 0.606911765584221 0.30352317485655 no 1047 0.27195473478615 1368 16648742
SGTC_2059 5238311 157 µM 0.606779722323409 0.303566973076692 no 1048 0.27199855346526 1315 703021
SGTC_1805 st050013 60.3 µM 0.606324930724142 0.303717847221186 no 1049 0.272149503349516 1318 4037144
SGTC_1810 st050138 53 µM 0.605036683284289 0.304145396433373 no 1050 0.272577311480479 1331 3444541
SGTC_1742 st038235 28.8875 µM 0.603142177703413 0.304774639921377 no 1051 0.273207054939209 1342 564103 YBR002C RER2
SGTC_2777 climbazole 1.536 µM 0.600769754007841 0.305563434698405 no 1052 0.273996676025486 1340 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_3154 9100113 49.47 µM 0.599866323199487 0.305864049387697 no 1053 0.274297663935121 1322 25237525
SGTC_2725 haloperidol 53.21 µM 0.592701367438711 0.30825279382823 no 1054 0.276690513071279 1310 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_244 nsc-207895 1.295 µM 0.591704146488431 0.30858590789729 no 1055 0.277024359718588 1263 42640
SGTC_302 1094-0063 18.9 µM 0.590886364975249 0.308859199220625 no 1056 0.277298281230116 1306 5440289
SGTC_732 3970-1727 52.7 µM 0.589963748167949 0.309167652147969 no 1057 0.27760747697603 1400 1275699
SGTC_2967 9089538 49.85 µM 0.589875342117783 0.309197215479193 no 1058 0.277637113257611 1402 728216
SGTC_3169 9102970 49.47 µM 0.589868268735909 0.309199580899322 no 1059 0.277639484527904 1401 17027839
SGTC_1090 efavirenz 20.7 µM 0.58820818492658 0.309754950564523 no 1060 0.278196282096964 1376 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2652 actinonin 100 µM 0.587999227801749 0.309824886555359 no 1061 0.278266405568509 1331 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_202 3594-0513 34.79 µM 0.584257326904588 0.311078429073567 no 1062 0.279523598808179 1346 708429
SGTC_2511 berberine 10.47 µM 0.584120992492411 0.311124142835454 no 1063 0.27956945607878 1361 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_234 nsc-17383 10.7 µM 0.582488648500043 0.311671703893655 no 1064 0.280118792712457 1393 408974
SGTC_1957 st077035 62.4 µM 0.581781102801099 0.311909175833146 no 1065 0.280357067163719 1430 705593
SGTC_1790 st045711 43.5 µM 0.57856832759892 0.312988454877194 no 1066 0.281440240431568 1452 585119
SGTC_2317 5986382 200 µM 0.577973147207191 0.313188572385356 no 1067 0.28164112440064 1448 877883
SGTC_708 3448-5400 146 µM 0.577405059653375 0.313379631801527 no 1068 0.281832928523648 1356 3462195
SGTC_2667 digitoxin 100 µM 0.576468488283696 0.31369472918349 no 1069 0.282149281672665 1355 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1162 k048-0130 20.1 µM 0.575913797045767 0.313881412033149 no 1070 0.282336724705182 1348 6797406
SGTC_1530 rhein 70.4 µM 0.575106677161845 0.314153135538863 no 1071 0.282609576192433 1395 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2925 9010536 32.5 µM 0.574841522765343 0.314242423930414 no 1072 0.282699240801338 1443 2994177
SGTC_3342 9147791 14.508 µM 0.574135836589723 0.314480110449347 no 1073 0.282937942215932 1337 1838168
SGTC_1796 st049173 110.4 µM 0.570848786201686 0.31558825450741 no 1074 0.284051074662586 1337 94134
SGTC_429 1112-0049 25.5 µM 0.569875915773846 0.315916551486352 no 1075 0.284380930512342 1336 2836170
SGTC_1616 st002734 56.1 µM 0.569772063654962 0.315951605166087 no 1076 0.284416152823808 1394 4026101
SGTC_1080 nisoldipine 24.4 µM 0.567647498031278 0.316669082368124 no 1077 0.285137174052474 1361 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_50 0929-0078 56.389 µM 0.567312823741119 0.316782166669941 no 1078 0.285250833012711 1419 1377751
SGTC_2113 5491891 107.031 µM 0.566385436434884 0.317095614342637 no 1079 0.28556589637185 1362 789979
SGTC_1896 st058441 89 µM 0.564853426018172 0.317613706098564 no 1080 0.286086732198186 1324 688759
SGTC_1395 3486-0190 4.35 µM 0.564630710608188 0.317689053261346 no 1081 0.286162486060561 1475 6748079
SGTC_1126 isoteolin 1.0172 µM 0.564195748934189 0.317836227528064 no 1082 0.286310460305201 1346 133323
SGTC_1964 st076914 61 µM 0.562888209449685 0.318278821729864 no 1083 0.286755504695638 1392 24208661
SGTC_472 calcifediol 10 µM 0.56210738076053 0.318543251337594 no 1084 0.287021429969075 1401 5283731 A vitamin D metabolite.
SGTC_3136 9095672 49.47 µM 0.561940589690115 0.318599747542489 no 1085 0.28707824880788 1283 17217380
SGTC_3247 9135149 49.47 µM 0.56113058421809 0.318874176112608 no 1086 0.287354259980001 1371 8934436 YOR116C RPO31
SGTC_3354 9151612 71.43 µM 0.560217274282212 0.319183723218222 no 1087 0.287665622878537 1446 27261949
SGTC_209 4077-0173 175.592 µM 0.559193434297332 0.319530882072243 no 1088 0.288014856787381 1358 15993494
SGTC_624 k048-0052 28 µM 0.559148048729854 0.319546274861788 no 1089 0.288030342528383 1373 6835531
SGTC_206 4546-0025 72.014 µM 0.55876680683182 0.319675587628669 no 1090 0.28816043933456 1397 6620745 YIL048W NEO1
SGTC_1906 st060206 94.7 µM 0.55450644008901 0.321122142352759 no 1091 0.28961614973034 1394 5133468
SGTC_1671 st016596 74.5 µM 0.552431302711285 0.321827715573633 no 1092 0.290326444521822 1399 2829167
SGTC_3055 9094636 49.47 µM 0.552403621134461 0.321837132014374 no 1093 0.290335925106943 1450 25236176
SGTC_1000 4048-0884 8.67 µM 0.551016443237902 0.322309154684567 no 1094 0.290811201304344 1425 13040088
SGTC_976 1348-1067 47.6 µM 0.549326785524259 0.322884491045782 no 1095 0.291390604286508 1426 5310671 YGL099W LSG1
SGTC_914 3820-6779 408 µM 0.547937355509672 0.323357916347048 no 1096 0.291867458931394 1378 2893481
SGTC_1913 st060213 96.1 µM 0.546943810696672 0.323696625840071 no 1097 0.292208667868742 1466 688959
SGTC_47 0149-0135 24.25 µM 0.546177409022339 0.323957999762786 no 1098 0.292471996713345 1324 5239155
SGTC_2965 9082772 38.63 µM 0.545663922954319 0.324133167828949 no 1099 0.292648487675633 1468 16459634
SGTC_383 2324-0395 7.37 µM 0.544121056421979 0.324659727748128 no 1100 0.293179085761502 1478 3146421
SGTC_89 0302-0250 142.109 µM 0.543607799728701 0.324834973238226 no 1101 0.293355695653078 1474 4203518 YLR208W SEC13
SGTC_1898 st060199 18.6 µM 0.543411512264615 0.324902003546952 no 1102 0.293423250534851 1408 688866
SGTC_3149 9097855 49.47 µM 0.542041754141801 0.325369920679512 no 1103 0.293894871094386 1522 25236625 YMR079W SEC14
SGTC_651 3253-0966 34.4 µM 0.540134361122079 0.326021955633489 no 1104 0.294552187762952 1405 781462
SGTC_910 3454-3003 490 µM 0.538196975068491 0.326684788611571 no 1105 0.295220534091761 1381 820824
SGTC_3060 1327-0027 12.5 µM 0.537391233206084 0.326960616332642 no 1106 0.295498698857208 1382 16000455 YPR107C YTH1
SGTC_1560 lithocholic acid 53.1 µM 0.536140367955788 0.327389009416809 no 1107 0.295930771379193 1404 9903 A bile acid which acts as a detergent.
SGTC_3008 9078912 71.4286 µM 0.534369561053248 0.327995859542406 no 1108 0.296542937101468 1412 16648731
SGTC_704 1310-0270 142 µM 0.533051721685092 0.328447774087109 no 1109 0.296998888728526 1378 5718033
SGTC_2929 9013348 24.6 µM 0.53293355672572 0.328488307586872 no 1110 0.297039787601158 1443 2995952
SGTC_2223 6903751 107.57 µM 0.531983766529177 0.328814182367385 no 1111 0.297368619423295 1442 5598863
SGTC_1606 st000094 49.2 µM 0.531701325772558 0.328911113440601 no 1112 0.297466436780221 1476 1242210
SGTC_3278 9139605 49.47 µM 0.531119689191949 0.329110762016534 no 1113 0.297667920526338 1477 7958859
SGTC_80 0159-0065 512.242 µM 0.530652267938831 0.329271241159451 no 1114 0.297829884251458 1404 1548079
SGTC_1230 0170-0365 3.77 µM 0.530628371169195 0.329279446452449 no 1115 0.297838165677498 1496 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2140 5586273 200 µM 0.530384829044397 0.329363074765643 no 1116 0.297922571194207 1430 854421
SGTC_1678 st019265 80.2 µM 0.529245141782827 0.329754537798223 no 1117 0.298317702701868 1569 5367020
SGTC_321 4534-3890 65.3 µM 0.524929899897557 0.331238436956275 no 1118 0.299815961539474 1481 699746
SGTC_557 1315-0110 16.2 µM 0.5246884560192 0.33132154182232 no 1119 0.299899891797025 1404 6833801
SGTC_536 3852-0578 10.6 µM 0.52334368371067 0.331784563691973 no 1120 0.300367553408397 1542 2869208
SGTC_3211 9128781 49.47 µM 0.523203703231306 0.331832775500434 no 1121 0.300416252324189 1438 17194361
SGTC_723 4182-0001 115 µM 0.521950713147741 0.332264451901032 no 1122 0.300852323723877 1405 744821 YLR208W SEC13
SGTC_1371 2421-0008 32.7 µM 0.519671712799166 0.33305017672254 no 1123 0.301646202942047 1473 2827552
SGTC_745 0469-0705 296 µM 0.519583071357292 0.333080752234865 no 1124 0.301677099804585 1560 3486736
SGTC_1838 st055369 84.5 µM 0.518640229567126 0.333406039753925 no 1125 0.302005824787363 1417 676036
SGTC_1996 st072960 66.8 µM 0.516656691098484 0.334090784382213 no 1126 0.302697916871715 1455 1719405
SGTC_416 estradiol valerate 100 µM 0.51439747236277 0.334871370769087 no 1127 0.30348706304288 1465 13791 A steroid.
SGTC_957 1187-1561 14.1 µM 0.513794745359916 0.335079740755899 no 1128 0.303697751052896 1440 1538454
SGTC_323 4013-0906 34.3 µM 0.513534411754656 0.335169756923046 no 1129 0.303788772915021 1535 2910086
SGTC_2713 st079149 53.4 µM 0.513036205875803 0.335342049139779 no 1130 0.303962997286187 1493 3103253
SGTC_2900 5328528 85.29 µM 0.512930389635059 0.335378647538074 no 1131 0.304000007338001 1418 795359
SGTC_1507 4075-3230 155 µM 0.511169594596337 0.335987878378352 no 1132 0.304616153669743 1405 659771
SGTC_1485 3909-9022 254 µM 0.51107969220409 0.336018995971571 no 1133 0.304647627670028 1459 714516
SGTC_1735 st034310 56.75 µM 0.510693335075199 0.336152737173063 no 1134 0.30478290420539 1568 871153
SGTC_2236 dapsone 200 µM 0.510484562822784 0.336225014311018 no 1135 0.304856013454422 1458 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_610 4215-0184 155 µM 0.510403359431872 0.336253128632121 no 1136 0.304884451900197 1493 5605015
SGTC_2885 9057732 51.95 µM 0.509116952652503 0.336698631783554 no 1137 0.305335124834745 1457 6471414
SGTC_2135 5326629 150.42 µM 0.506631214361856 0.337560131639191 no 1138 0.306206801210809 1439 5020077
SGTC_276 colchicine 750 µM 0.505943838614561 0.337798510875608 no 1139 0.306448038006157 1506 2833 A microtubule depolymerizer.
SGTC_3282 9108498 15.4605 µM 0.505328079360402 0.338012109055405 no 1140 0.306664212010599 1450 16459645
SGTC_3293 9120939 62.045 µM 0.501439966204955 0.339362042700679 no 1141 0.308030759186921 1529 934087
SGTC_2810 7959871 45.46 µM 0.500164783437055 0.339805230205456 no 1142 0.30847952658153 1555 2974535
SGTC_2572 astragaloside iv 100 µM 0.498895327196997 0.340246647522489 no 1143 0.308926563064495 1506 45006101 An anti-inflammatory agent.
SGTC_887 0885-0007 9.62 µM 0.498231319835374 0.340477624484536 no 1144 0.309160504777688 1547 5719458
SGTC_23 0213-0011 39.996 µM 0.498133656848054 0.340511601899576 no 1145 0.309194919733015 1555 627608
SGTC_1775 st081588 35.1725 µM 0.498122684257351 0.340515419396653 no 1146 0.309198786412168 1479 1426443 YGL099W LSG1
SGTC_1774 st048371 48.465 µM 0.49707166844168 0.340881156205619 no 1147 0.309569256377487 1444 4242727
SGTC_592 k241-0073 46.5 µM 0.496536306415065 0.341067511219542 no 1148 0.309758039255319 1571 4230158
SGTC_2671 danthron 100 µM 0.496422078658015 0.341107277961094 no 1149 0.309798325496318 1472 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1287 0971-0001 34.6 µM 0.495876359306879 0.341297286612285 no 1150 0.309990823208403 1507 4665869
SGTC_83 0170-0301 39.027 µM 0.492712934036844 0.342399519960512 no 1151 0.311107718683896 1492 3089716
SGTC_1579 chlormadinone acetate 49.4 µM 0.492540994596089 0.342459467462793 no 1152 0.311168474519021 1577 45114258 A steroidal progestin.
SGTC_2350 9023895 38.85 µM 0.492190567152343 0.342581657941041 no 1153 0.311292316091697 1562 2997209
SGTC_1271 0832-2808 169 µM 0.490118086707853 0.343304647217058 no 1154 0.312025170088197 1588 3663794
SGTC_290 2043-6722 48.1 µM 0.489689290886855 0.343454305297298 no 1155 0.312176890512393 1516 773758 YLR208W SEC13
SGTC_2678 equilin 100 µM 0.488272108579029 0.34394910400011 no 1156 0.312678557350264 1593 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_320 4092-0846 5.34 µM 0.487846203849067 0.344097857768239 no 1157 0.312829390804151 1547 1359356
SGTC_400 oxethazaine 37.5 µM 0.487257758681269 0.34430342097542 no 1158 0.313037839247827 1488 4621 A local anesthetic.
SGTC_282 k297-0036 65.7 µM 0.486112738325993 0.344703545969436 no 1159 0.313443617913665 1519 5061378
SGTC_1935 st074532 41.6 µM 0.485572668586782 0.344892332566649 no 1160 0.313635089259853 1631 2829742
SGTC_3101 9120531 49.47 µM 0.485352927691902 0.344969156177082 no 1161 0.313713008546378 1553 24824904
SGTC_2752 diclazuril 33.15 µM 0.485129270128585 0.345047355656954 no 1162 0.313792325202831 1536 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3192 9110362 49.47 µM 0.48396420030501 0.345454816848126 no 1163 0.314205638110927 1560 16649480
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.482670269927382 0.34590755455462 no 1164 0.314664937980824 1465 6708630 An antioxidant.
SGTC_409 arachidonic acid 100 µM 0.477903616232625 0.347577272390448 no 1165 0.316359403717995 1524 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1292 0kpi-0043 232 µM 0.477097930715241 0.347859790568296 no 1166 0.316646194062256 1492 3333905
SGTC_1009 4106-0057 9.87 µM 0.477011711312016 0.347890028896311 no 1167 0.316676891097043 1517 2928005
SGTC_1089 terbinafine 2.25 µM 0.476964926958023 0.347906437216252 no 1168 0.316693548443855 1565 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1506 4226-2149 212 µM 0.476118292991689 0.348203419882648 no 1169 0.316995052641573 1557 991114
SGTC_2823 7987624 58.44 µM 0.475841716063389 0.348300457854585 no 1170 0.317093573864479 1522 2239440
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.475082758127638 0.348566791872067 no 1171 0.317363993682778 1522 688662
SGTC_274 sirtinol 40.1 µM 0.474911757494603 0.348626809837385 no 1172 0.317424935374087 1469 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2663 amphotericin b 100 µM 0.473839455186651 0.349003253847322 no 1173 0.317807198287656 1507 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_814 3342-0569 96 µM 0.472865897231648 0.349345161287656 no 1174 0.318154428297791 1544 4346283
SGTC_3333 9141820 12.094 µM 0.472791688648571 0.349371227895377 no 1175 0.318180902155678 1518 1939433
SGTC_107 0358-0022 2.6945 µM 0.472649292226042 0.349421248245698 no 1176 0.318231704576686 1592 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_316 k060-0003 58.6 µM 0.472295573979472 0.349545512054026 no 1177 0.318357914558895 1558 6152314
SGTC_3272 9137413 49.47 µM 0.472272304369975 0.349553687403516 no 1178 0.318366218112787 1434 17614870
SGTC_62 0180-0423 3.232 µM 0.471687624586034 0.349759126791076 no 1179 0.318574885853953 1468 30102 YGL099W LSG1
SGTC_2026 5148700 152 µM 0.469576362217147 0.350501328594266 no 1180 0.319328857989839 1500 79838
SGTC_2941 9056145 11.23 µM 0.468452219848772 0.350896747389328 no 1181 0.319730615986028 1460 2119517
SGTC_1377 2944-0135 198 µM 0.467470880640567 0.351242067037487 no 1182 0.320081510485502 1584 1894137
SGTC_11 0438-0307 1.3 µM 0.466519283392341 0.351577038232671 no 1183 0.320421924007811 1620 4011476
SGTC_2296 7971656 126.45 µM 0.464853409071377 0.352163719116588 no 1184 0.321018218626742 1514 666570
SGTC_1888 azatryptophan 97.5 µM 0.46368288570548 0.352576159975729 no 1185 0.321437480287933 1510 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1214 0358-0031 63.7 µM 0.462807599908496 0.35288468544847 no 1186 0.321751141613361 1717 4301366
SGTC_1011 4112-3381 17.4 µM 0.462310456384089 0.35305996438839 no 1187 0.321929351108523 1570 2877139
SGTC_721 1187-1332 279 µM 0.461879051948538 0.353212090831369 no 1188 0.322084028514361 1475 25730
SGTC_2367 9070478 135.38 µM 0.453746262768776 0.356084327343445 no 1189 0.325005732524351 1548 572802
SGTC_2416 tofa 880 nM 0.452950179819636 0.356365920413318 no 1190 0.325292308168233 1451 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1546 5-methoxyflavanone 78.7 µM 0.452103600787534 0.356665461067295 no 1191 0.325597174892174 1624 147795
SGTC_702 1488-0190 94 µM 0.450563833985487 0.357210495291219 no 1192 0.32615196873069 1657 949357
SGTC_868 0527-0199 213 µM 0.449865035093691 0.357457946708679 no 1193 0.32640388025313 1569 2849450
SGTC_551 k048-0028 34.9 µM 0.449724013495374 0.357507891087038 no 1194 0.326454727041789 1638 6836383
SGTC_2000 st075254 36.4 µM 0.448982768820214 0.357770451299181 no 1195 0.326722043443018 1528 17234175
SGTC_1666 st014829 29 µM 0.448427068254024 0.357967333101834 no 1196 0.326922505102458 1526 3858230
SGTC_2281 7943571 200 µM 0.448308322874216 0.358009408869837 no 1197 0.326965347414201 1650 1244024
SGTC_2710 st078562 53.7235 µM 0.447878122474018 0.358161858818027 no 1198 0.327120579114225 1494 17250908
SGTC_2344 7990960 76.95 µM 0.447706321513237 0.358222746178393 no 1199 0.32718257940846 1564 140813
SGTC_1497 4476-2978 41.3 µM 0.446438426284909 0.358672207765987 no 1200 0.327640290446427 1566 1528379
SGTC_3118 9124250 49.47 µM 0.445596755145388 0.358970683532097 no 1201 0.32794427745479 1532 1504786
SGTC_177 1327-0068 8.361 µM 0.44549350848067 0.359007303085904 no 1202 0.327981574986951 1525 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1795 st049545 62.3 µM 0.444450201396343 0.359377416157931 no 1203 0.328358562584944 1652 5291882
SGTC_1161 k007-0610 110 µM 0.443655669962791 0.359659364642436 no 1204 0.328645775122301 1602 5843850
SGTC_997 3996-0078 137 µM 0.443430890909396 0.359739143908976 no 1205 0.328727048140266 1570 735687
SGTC_2473 5854593 8.94 µM 0.443352008589669 0.359767142511266 no 1206 0.328755571420265 1556 2872951
SGTC_2796 7949634 45.45 µM 0.442572355342912 0.360043914196788 no 1207 0.32903754206378 1540 2971588
SGTC_2096 5468907 200 µM 0.442556365165578 0.360049591371205 no 1208 0.329043326115794 1682 759785
SGTC_3161 9100388 49.47 µM 0.441502369976101 0.360423871285979 no 1209 0.329424673074567 1626 25236368
SGTC_937 3122-0005 46.7 µM 0.440617425795892 0.360738223526815 no 1210 0.329744992625297 1677 759535
SGTC_714 4296-0578 26.1 µM 0.440260763235939 0.360864944778717 no 1211 0.329874127615008 1646 1589775
SGTC_3004 9076122 71.4286 µM 0.439901029609453 0.360992772646341 no 1212 0.330004395071665 1635 44782551
SGTC_3088 9117578 49.47 µM 0.439788206976469 0.36103286627781 no 1213 0.330045254875489 1586 678341
SGTC_1189 1431-2119 7.28 µM 0.439549649528635 0.361117647153046 no 1214 0.330131657429389 1573 3107275
SGTC_625 k213-0058 121 µM 0.438078582870113 0.361640599801056 no 1215 0.330664659609479 1641 3655420
SGTC_1812 st052057 4.327 µM 0.437299135203427 0.361917792175135 no 1216 0.330947211220247 1536 3645418
SGTC_91 0417-1751 58.384 µM 0.436585432418182 0.36217166746478 no 1217 0.331206014640523 1585 6795624
SGTC_2552 juarezic acid 87.02 µM 0.432233894556411 0.363720886196184 no 1218 0.332785713546264 1572 1549512
SGTC_1299 1079-1439 3.74 µM 0.431336206031159 0.364040756403916 no 1219 0.333111964025952 1529 323161
SGTC_967 1306-0166 352 µM 0.43108385380092 0.364130693261057 no 1220 0.333203700152876 1691 4437607
SGTC_1874 staurosporine 7.6 µM 0.430981054274969 0.364167332555524 no 1221 0.333241073123026 1652 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2021 4019055 173 µM 0.430917838372424 0.364189864268802 no 1222 0.33326405621114 1577 44827708 YER133W GLC7
SGTC_3135 9127742 49.47 µM 0.430232422466361 0.364434193594627 no 1223 0.333513289608325 1573 3643468
SGTC_903 1134-0042 114 µM 0.429496819588441 0.364696474295071 no 1224 0.333780853947387 1553 701009
SGTC_623 k072-0108 16.9 µM 0.425940136749164 0.365965508313063 no 1225 0.335075733668795 1603 5382803
SGTC_2468 5987765 72.9 µM 0.422349329060093 0.367248207420104 no 1226 0.336385028648878 1634 26772094
SGTC_2020 4017018 200 µM 0.422186829877369 0.367306290140586 no 1227 0.336444326867935 1582 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_15 0266-0086 27.098 µM 0.421699411477101 0.36748052822008 no 1228 0.33662221704062 1651 1712902 YIL048W NEO1
SGTC_1097 itavastatin 7.23 µM 0.420784573674013 0.367807630101046 no 1229 0.336956198611729 1605 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2864 9034755 47.6 µM 0.419850189028998 0.368141819986218 no 1230 0.337297448925256 1582 4930451
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.419705577631755 0.368193550294335 no 1231 0.337350274997226 1640 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2194 5927483 104.545 µM 0.418270911117297 0.368706887722679 no 1232 0.337874527544524 1615 760979
SGTC_2993 9054257 71.4286 µM 0.416346542092735 0.369395813281213 no 1233 0.338578220041211 1564 6470217 YGL055W OLE1
SGTC_2693 st077581 40.7 µM 0.414800867650467 0.369949469888291 no 1234 0.339143842181525 1616 25238761
SGTC_2973 9094665 17.96 µM 0.413642924964228 0.370364418722712 no 1235 0.339567815995564 1721 25237061 YIL048W NEO1
SGTC_2051 5263410 176 µM 0.412280311304057 0.37085290464708 no 1236 0.340066988979547 1634 227584
SGTC_522 1273-0010 11.6 µM 0.411683765671398 0.37106682698886 no 1237 0.340285612812185 1660 5705015
SGTC_453 enantio-paf c16 10 µM 0.411166020835235 0.371252523526318 no 1238 0.340475401021523 1593 13871343 A lipid and platelet activating factor
SGTC_1396 3511-0007 98.6 µM 0.410442323769558 0.371512137982279 no 1239 0.340740752240183 1598 X1396
SGTC_251 melphalan 456.522 µM 0.409840300225967 0.371728148605416 no 1240 0.340961550638379 1701 460612 A DNA alkylator.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.409684353884773 0.371784109927176 no 1241 0.341018754468997 1638 1241132 A phosphatase inhibitor.
SGTC_1503 4585-0012 61.3 µM 0.409181410181571 0.371964609654715 no 1242 0.341203267863053 1683 2922052
SGTC_1673 st016611 27.3 µM 0.403067293855474 0.374161123399787 no 1243 0.343449360096053 1708 5226799
SGTC_2087 5276107 200 µM 0.402467038682464 0.374376988493746 no 1244 0.343670170760478 1600 144405
SGTC_3092 9117248 49.47 µM 0.400064960115544 0.375241222848285 no 1245 0.344554335829631 1709 17141857
SGTC_898 1000-0849 28.3 µM 0.397815629896543 0.376051068744168 no 1246 0.345383047574572 1670 6751807
SGTC_1926 methyl fluorone black 53.6 µM 0.397445913231752 0.37618423340281 no 1247 0.345519331894091 1549 72721 Reacts with homocysteine.
SGTC_1828 st055811 49 µM 0.395002871845633 0.37706453863908 no 1248 0.346420384267799 1743 5877589
SGTC_504 lovastatin 124 µM 0.393324648239267 0.377669626544214 no 1249 0.347039857795616 1583 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1691 st019933 84.6 µM 0.391882067602836 0.378189992868192 no 1250 0.347572676696068 1739 6176082
SGTC_3003 9075612 71.4286 µM 0.391875721508255 0.378192282514428 no 1251 0.347575021300097 1645 6501993
SGTC_1784 st039334 36.3 µM 0.391143914335882 0.378456344364863 no 1252 0.347845431085646 1745 3496984
SGTC_2077 5212015 200 µM 0.388972793293936 0.379240095052053 no 1253 0.348648136237208 1563 780900
SGTC_2316 5844804 197.44 µM 0.388781281342555 0.379309252629991 no 1254 0.348718974479936 1780 776813
SGTC_1076 itraconazole 331 nM 0.3873795163789 0.379815566544233 no 1255 0.349237632948166 1636 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3144 9087057 49.47 µM 0.387192561152356 0.379883109888895 no 1256 0.349306828417304 1798 17249618
SGTC_2506 ethyl hematommate 54.16 µM 0.383828379808912 0.381099148589963 no 1257 0.35055282608886 1572 3940691 An allergen.
SGTC_2472 5377652 49.4 µM 0.383496240747943 0.381219269647785 no 1258 0.350675928524428 1625 1610903
SGTC_980 1473-0395 201 µM 0.381759008236376 0.38184774153843 no 1259 0.351320063327251 1609 768876
SGTC_2563 tomatine 8.54 µM 0.380098739450551 0.382448661739335 no 1260 0.351936060733296 1907 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_777 1315-0167 517 µM 0.37993617222001 0.382507516813947 no 1261 0.351996397791272 1602 4221767
SGTC_1058 3448-5425 97.3 µM 0.377842030522325 0.383265912217543 no 1262 0.352773974183036 1662 7279705
SGTC_700 3453-2283 142 µM 0.374111110925644 0.384618175666502 no 1263 0.35416082630971 1733 565664
SGTC_949 1165-0505 146 µM 0.373071250869714 0.384995321703225 no 1264 0.354547707507823 1633 6244267
SGTC_2945 9067681 61.76 µM 0.372657152895403 0.38514554089418 no 1265 0.354701814975775 1695 16456930
SGTC_2537 larixol 68.93 µM 0.372431716542004 0.385227327983365 no 1266 0.354785721608006 1708 6708759
SGTC_665 3914-0008 307 µM 0.3707095510523 0.38585228852582 no 1267 0.355426937865941 1620 1069549
SGTC_2095 5432005 200 µM 0.370372463229935 0.385974649825921 no 1268 0.355552494213283 1652 783734
SGTC_250 brefeldin a 552.239 µM 0.370174905813805 0.386046367515833 no 1269 0.35562608644121 1648 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1621 st003705 32.4 µM 0.369840529569509 0.386167762324188 no 1270 0.35575065739283 1773 24207032
SGTC_1351 1496-0003 46.5 µM 0.368972759250998 0.386482857039757 no 1271 0.356074014683476 1746 3891978
SGTC_2679 rapamycin 1 nM 0.368478114005607 0.38666250041022 no 1272 0.356258380711406 1698 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2108 5365811 200 µM 0.367632388361869 0.386969704066097 no 1273 0.356573680569315 1730 780283
SGTC_3213 9129884 49.47 µM 0.367418081839723 0.387047560597611 no 1274 0.356653592998712 1544 17190742
SGTC_3336 9143619 71.43 µM 0.366554244296454 0.387361434683791 no 1275 0.356975771821108 1742 45595730
SGTC_2361 9034121 116 µM 0.366271417636898 0.387464215343107 no 1276 0.357081277679603 1659 6496917
SGTC_2556 citropten 84.59 µM 0.366068266170642 0.387538046496536 no 1277 0.357157068192774 1603 2775 A potential DNA crosslinker.
SGTC_333 3486-0131 40.1 µM 0.364815551426339 0.387993409252757 no 1278 0.357624547827917 1808 6744690
SGTC_2704 st078022 71.1 µM 0.364695878313297 0.388036918590994 no 1279 0.357669217824921 1807 54697681
SGTC_2696 st077691 74.316 µM 0.363571302070486 0.388445847339645 no 1280 0.358089079938326 1689 757133
SGTC_1613 st002381 52.1 µM 0.361874073955415 0.389063243077946 no 1281 0.358723067393288 1675 551167
SGTC_1001 4048-4355 44.4 µM 0.36041109858243 0.389595650324978 no 1282 0.35926986404045 1641 21824233
SGTC_2571 chrysanthemic acid 100 µM 0.359266205368296 0.390012445466102 no 1283 0.359697976595629 1608 2743 An insecticide.
SGTC_2164 5685496 200 µM 0.359166983292256 0.390048572945284 no 1284 0.359735087235441 1761 759046
SGTC_54 0159-0055 9 µM 0.357942255025366 0.390494583530098 no 1285 0.360193263964181 1798 3319099
SGTC_1273 0849-0096 14.1 µM 0.357683689176517 0.390588764175089 no 1286 0.360290020395067 1663 5286025
SGTC_1609 st001574 46.4 µM 0.357210056405721 0.390761297957509 no 1287 0.360467278980567 1654 3960012
SGTC_1933 st074711 15.9 µM 0.356812192580768 0.390906247437875 no 1288 0.360616203975265 1651 17250958
SGTC_1050 3232-1156 69.3 µM 0.356788512550665 0.390914875008591 no 1289 0.360625068349087 1663 700529
SGTC_3317 9138495 8.753 µM 0.355235399819057 0.391480852403371 no 1290 0.361206623338725 1691 17020139
SGTC_2431 5490079 200 µM 0.354916380725164 0.391597136198931 no 1291 0.361326118153045 1653 5722345
SGTC_2237 6667747 47.222 µM 0.354910772025998 0.391599180679943 no 1292 0.361328219121607 1655 729940 YDL015C TSC13
SGTC_2202 7226349 200 µM 0.354139844246288 0.391880227464957 no 1293 0.361617041544711 1678 844334
SGTC_1947 st076332 61.6 µM 0.353320222688442 0.392179087771727 no 1294 0.361924193223387 1794 24208416
SGTC_61 0978-8327 98.565 µM 0.349276728944603 0.393654403124795 no 1295 0.363440783637174 1726 6150059 YHR072W ERG7
SGTC_627 1391-0720 175 µM 0.348416867502186 0.393968331213963 no 1296 0.363763568376141 1709 997839
SGTC_798 1287-0182 476 µM 0.347761286280031 0.394207724644176 no 1297 0.364009733033913 1835 1649755
SGTC_2521 angolensin 13.4 µM 0.345619003374036 0.394990283489359 no 1298 0.364814531254393 1743 821428 A flavenoid.
SGTC_2218 6965428 192.983 µM 0.343364537041016 0.395814279691491 no 1299 0.365662117462698 1784 675684
SGTC_1082 camptothecin 424.86 nM 0.341550502609579 0.396477638641547 no 1300 0.366344596205681 1491 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_711 k292-0785 179 µM 0.340250710475025 0.396953133135091 no 1301 0.366833866177618 1672 4146315
SGTC_306 1672-3436 11.6 µM 0.338583904000953 0.397563114260434 no 1302 0.367461604938344 1773 6797378
SGTC_471 1-acyl-paf 4 µM 0.336747562457928 0.39823542814775 no 1303 0.368153602787948 1659 16759367
SGTC_652 0437-0092 114 µM 0.334457160326935 0.399074404209455 no 1304 0.36901730624124 1683 3091274
SGTC_2248 tofa 1.1 µM 0.333938250380682 0.399264546269644 no 1305 0.369213077661959 1752 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2980 9014342 25.29 µM 0.333324899897926 0.399489324609748 no 1306 0.369444522823312 1722 2996599
SGTC_1342 1486-1464 234 µM 0.331376533161104 0.400203575303373 no 1307 0.370180044165186 1721 3253938
SGTC_1344 1488-0097 29.1 µM 0.331299027763439 0.400231994886241 no 1308 0.370209312806642 1765 747966
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.33113114679398 0.400293555082777 no 1309 0.37027271287641 1903 551469
SGTC_1878 temozolomide 1 mM 0.330515748772902 0.400519236277083 no 1310 0.370505147413193 1873 5394 DNA alkylating agent.
SGTC_1804 st050076 49.1 µM 0.328538952947838 0.401244399007432 no 1311 0.371252098517476 1776 3895976
SGTC_2321 7390090 138.78 µM 0.327604364986899 0.401587359502763 no 1312 0.371605410572955 1671 649046
SGTC_1902 st060212 70.5 µM 0.326568110356291 0.401967716674277 no 1313 0.371997283216647 1717 688944
SGTC_3047 9092122 49.47 µM 0.324862693409903 0.402593891837637 no 1314 0.372642496542656 1707 17173831
SGTC_352 k048-0007 5.11 µM 0.324568480112414 0.402701942982046 no 1315 0.372753842976136 1757 6811911
SGTC_867 0518-0118 155 µM 0.324335011507923 0.402787690656681 no 1316 0.372842207856434 1807 6848158
SGTC_3240 9133527 49.47 µM 0.32427061308192 0.40281134354754 no 1317 0.372866583014497 1748 17617455
SGTC_464 bw-b 70c 158 µM 0.322572874086028 0.403435033961534 no 1318 0.37350936987302 1834 5353454
SGTC_2733 amorolfine 100 µM 0.322392646977117 0.403501257601558 no 1319 0.373577626987625 1847 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_983 1491-0821 12.2 µM 0.320854455055642 0.404066571698106 no 1320 0.374160345039164 1853 46495113
SGTC_2986 9022445 71.43 µM 0.320436647272598 0.404220158477526 no 1321 0.374318674198529 1858 6459286
SGTC_1018 4259-0013 28.1 µM 0.320246352222422 0.404290116123662 no 1322 0.374390793945547 1764 6801262
SGTC_2855 9016525 58.44 µM 0.319081530145617 0.404718403085693 no 1323 0.374832344504126 1728 43811474
SGTC_832 4083-0019 164 µM 0.318204274603212 0.405041031710149 no 1324 0.375164995247452 1851 1990758
SGTC_362 0310-0100 9.03 µM 0.317407930885601 0.405333959262179 no 1325 0.375467045070955 1732 790235
SGTC_2011 4012611 177 µM 0.316087113188949 0.405819926495387 no 1326 0.375968193937616 1692 2049887
SGTC_226 1,3-diallylurea 8.28947 mM 0.31583790852057 0.405911632440396 no 1327 0.37606277145902 1778 74537 YKL182W FAS1
SGTC_2045 5106652 78.05 µM 0.315777407109357 0.405933897405521 no 1328 0.37608573392385 1840 673349
SGTC_860 0443-0016 25.1 µM 0.315734322290257 0.405949753121908 no 1329 0.376102086432072 1773 5337942
SGTC_1316 1272-0050 65.9 µM 0.315527204670634 0.406025976976724 no 1330 0.376180699419355 1764 7340392
SGTC_892 0929-0076 29 µM 0.314855937291038 0.406273042654848 no 1331 0.376435519090638 1742 5751038
SGTC_974 1326-0144 138 µM 0.314562600202948 0.406381019594041 no 1332 0.376546889639612 1727 5411856
SGTC_864 0469-0573 172 µM 0.31371593605292 0.406692715292882 no 1333 0.376868398080782 1708 689425
SGTC_1540 guanosine 70.6 µM 0.31331367629055 0.406840826192381 no 1334 0.377021180337474 1848 6802 Guanosine is a purine nucleoside
SGTC_2850 9015429 58.44 µM 0.312666893799135 0.407078997593928 no 1335 0.377266875121334 1709 6457570
SGTC_859 0439-0102 54.6 µM 0.312320886517694 0.407206425546294 no 1336 0.377398334127925 1892 610143
SGTC_1861 st057647 17.4 µM 0.310874951953824 0.407739042096436 no 1337 0.377947843541574 1888 688668
SGTC_1112 tnp00069 1.16933 µM 0.310750015711007 0.407785070947396 no 1338 0.377995335614715 1863 145826
SGTC_2053 5265679 138 µM 0.309875086546455 0.408107446867674 no 1339 0.378327974484556 1712 764595
SGTC_151 3013-0144 2.285 µM 0.309853393546266 0.4081154406499 no 1340 0.378336223082005 1868 906558 YHR107C CDC12
SGTC_730 1436-0052 41.2 µM 0.307662832088163 0.408922849988625 no 1341 0.379169452206128 1788 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_385 1494-0393 12.4 µM 0.30729950634677 0.40905680408622 no 1342 0.379307705700826 1806 3090647
SGTC_1557 sumaresinolic acid 42.3 µM 0.306023167162174 0.4095274600255 no 1343 0.379793503295264 1732 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1771 st048882 4.1505 µM 0.305868837384791 0.409584378691788 no 1344 0.379852256853222 1692 4580403
SGTC_2712 st079126 47.7 µM 0.305044516109487 0.409888430475815 no 1345 0.38016612403284 1754 3152970
SGTC_1417 3966-0327 90.4 µM 0.305012096120309 0.409900389732265 no 1346 0.380178469827794 1787 651118
SGTC_9 0092-0002 10.449 µM 0.30462323397853 0.410043841777121 no 1347 0.380326561197493 1787 759368
SGTC_872 0588-0139 234 µM 0.304487769458964 0.410093817745964 no 1348 0.380378154620183 1754 2047100
SGTC_2183 6420625 130.508 µM 0.303078232276485 0.410613914853152 no 1349 0.380915121290404 1750 2897619
SGTC_2276 7947513 42.08 µM 0.302781396335243 0.410723462729681 no 1350 0.381028230954526 1618 2105100
SGTC_2278 7948257 134.34 µM 0.30215572277926 0.410954391562988 no 1351 0.381266677843129 1939 1247028
SGTC_3024 9090631 49.47 µM 0.302150734053089 0.410956232967934 no 1352 0.38126857924945 1925 25236383
SGTC_641 4092-0595 30 µM 0.302112194386475 0.410970458535781 no 1353 0.381283268379508 1851 786260
SGTC_1046 2001-0062 216 µM 0.301769446174046 0.41109697718048 no 1354 0.381413912035815 1738 739778
SGTC_1990 st072050 59.8 µM 0.301316078354939 0.411264343044234 no 1355 0.381586740782212 1738 17233948
SGTC_2347 9049783 174.81 µM 0.301272778600373 0.411280328484307 no 1356 0.381603248355573 1852 6467988 YPL169C MEX67
SGTC_1637 st007924 17.4 µM 0.296124281532295 0.413182097828134 no 1357 0.38356758557515 1760 683336
SGTC_3299 9121982 43.1275 µM 0.295349822062811 0.413468347815514 no 1358 0.383863330271369 1756 17594604 YPL160W CDC60
SGTC_1588 farnesol 29.9 µM 0.294404730672449 0.413817727815064 no 1359 0.384224326229137 1771 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_733 4069-0007 56.1 µM 0.294182624333814 0.413899845672574 no 1360 0.38430917863543 1819 5717425 YNL287W SEC21
SGTC_854 0422-0053 192 µM 0.293441063802765 0.414174045026535 no 1361 0.384592520887295 1758 3596728
SGTC_2116 5511452 16.8835 µM 0.293036702774698 0.4143235791593 no 1362 0.384747048847469 1813 870744
SGTC_128 0906-2981 13.371 µM 0.29217247829292 0.414643214028523 no 1363 0.385077376572255 1894 6740226
SGTC_1219 1469-0211 33.1 µM 0.291888569835343 0.414748230391189 no 1364 0.38518591153995 1895 6822282
SGTC_1876 myriocin 605 nM 0.290424959109681 0.415289709418098 no 1365 0.385745575770582 1920 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_237 nikkomycin 200 µM 0.288702502148291 0.41592715755246 no 1366 0.386404523881935 1897 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3018 9082602 49.47 µM 0.28831770167681 0.416069595087897 no 1367 0.386551779115765 1811 17332089
SGTC_1486 3970-0793 4.53 µM 0.287771616786922 0.416271752497452 no 1368 0.386760782622862 1917 2844330
SGTC_1234 0326-0494 15.5 µM 0.287610757927856 0.416331305725571 no 1369 0.386822354528235 1883 1547813
SGTC_2291 7917025 104.35 µM 0.285831083455764 0.416990305371505 no 1370 0.387503749855879 1748 2964612
SGTC_2044 5102272 200 µM 0.285016067349865 0.417292177509422 no 1371 0.387815916139937 1798 592666
SGTC_2646 retinol 96.75 µM 0.283661197535643 0.417794112769265 no 1372 0.388335016801968 1824 445354 A vitamin A analog and teratogen.
SGTC_848 0368-0089 85.6 µM 0.282990569448124 0.418042608304583 no 1373 0.388592033071573 1900 762535
SGTC_269 exalamide 29 µM 0.280354454116955 0.419019714629504 no 1374 0.389602788364642 1830 3316 A derivative of salicylamide.
SGTC_1505 k297-0037 20.6 µM 0.279801825489073 0.419224616317254 no 1375 0.38981477554224 1764 4089396
SGTC_763 3453-1109 128 µM 0.279747951868461 0.419244592560617 no 1376 0.389835443104221 1940 1560353
SGTC_2952 9073731 13.78 µM 0.279683021290035 0.419268668981035 no 1377 0.389860352865972 1757 16457353
SGTC_164 4100-3994 89.624 µM 0.279623457283447 0.419290755729079 no 1378 0.389883204210906 1957 4615967
SGTC_3147 9097027 49.47 µM 0.277911864117752 0.419925534767695 no 1379 0.390540008140785 1857 25236841
SGTC_1341 1486-1360 280 µM 0.277750127622117 0.419985528828657 no 1380 0.390602088823641 1802 3976547
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.276026231331675 0.420625101118371 no 1381 0.391263959453426 1844 97141
SGTC_2306 7482397 179.52 µM 0.275234928605784 0.420918747821361 no 1382 0.391567876849735 1918 891448
SGTC_277 nystatin 15.5 µM 0.274436140074421 0.421215217082087 no 1383 0.39187473647639 1761 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_197 4544-0043 41.561 µM 0.274112869738993 0.421335211129017 no 1384 0.391998941937114 1834 896523
SGTC_3264 9137442 49.47 µM 0.273895315338302 0.421415968810612 no 1385 0.392082535898143 1917 17015726
SGTC_475 α-linolenic acid 10 µM 0.273573403002983 0.421535470935093 no 1386 0.392206237901063 1916 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1873 rapamycin 2 nM 0.272154192349957 0.422062404391874 no 1387 0.392751731014547 1791 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3205 9113483 49.47 µM 0.271735047087341 0.422218054016068 no 1388 0.39291287561004 1924 17018033
SGTC_1331 1472-0049 76.2 µM 0.270521751360435 0.422668679871137 no 1389 0.393379442680031 1780 24051409
SGTC_674 0498-0004 451 µM 0.270002942591847 0.422861399721394 no 1390 0.393578994897199 1787 4231473
SGTC_3307 9126885 69.2785 µM 0.269760016587467 0.422951644836865 no 1391 0.393672442449995 1747 24824909
SGTC_3355 9151058 44.0485 µM 0.269186144122065 0.423164850030442 no 1392 0.393893221133903 1905 17015728
SGTC_767 0929-0023 86 µM 0.267430237425599 0.423817344285071 no 1393 0.394568960429064 1812 1204563
SGTC_2212 7123476 200 µM 0.266464293075641 0.424176378029289 no 1394 0.394940827789711 1902 1085715
SGTC_1863 st057641 20.1 µM 0.266213233723615 0.42426970508744 no 1395 0.395037495813106 1995 3921635
SGTC_1456 k015-0012 13 µM 0.265009349762849 0.424717287456503 no 1396 0.395501129593704 2008 2989616
SGTC_2984 9022109 38.96 µM 0.264853773502473 0.424775135002986 no 1397 0.395561055154077 1988 6459207
SGTC_1738 st035555 74 µM 0.26437670298245 0.424952533082058 no 1398 0.395744830702323 1863 5331140
SGTC_990 3985-0011 41.3 µM 0.262164016839404 0.425775515838499 no 1399 0.396597496898364 1844 5399565 YGL099W LSG1
SGTC_3097 9117246 49.47 µM 0.260131392253767 0.426531811929217 no 1400 0.39738121185685 1822 16423892
SGTC_1767 st044992 70.3 µM 0.259337390586611 0.426827316499234 no 1401 0.397687466225334 1799 9600693
SGTC_2597 laccaic acid a 100 µM 0.259010907249592 0.426948836127407 no 1402 0.397813412415702 1836 5491415 A textile dye.
SGTC_1171 0368-0077 21.4 µM 0.257302301209197 0.42758490536376 no 1403 0.398472708068945 1840 3239779
SGTC_2849 9019321 12.99 µM 0.253825219480759 0.428879911439215 no 1404 0.399815294513877 1855 16489627
SGTC_2266 7929956 200 µM 0.253796824494351 0.428890490054408 no 1405 0.399826263414405 1807 2967153
SGTC_1948 st076329 66.6 µM 0.253335080861921 0.429062520833063 no 1406 0.400004644722822 1940 24208413
SGTC_2184 6075246 200 µM 0.251384927470965 0.429789233326228 no 1407 0.400758259885259 1910 2267320
SGTC_1659 st012954 42.1 µM 0.249776918869647 0.430388626805052 no 1408 0.4013799350823 1929 24207262
SGTC_3326 9140064 16.379 µM 0.248979936076396 0.430685765790229 no 1409 0.401688150741787 1803 1868434
SGTC_341 1486-1430 230 µM 0.248849717328198 0.430734318962701 no 1410 0.401738515812099 1812 2054753 YPL210C SRP72
SGTC_2805 7950783 58.44 µM 0.248277586026952 0.43094765540121 no 1411 0.401959819967077 1882 1178958 YDL195W SEC31
SGTC_1912 st060209 90.8 µM 0.248086621648822 0.431018866726584 no 1412 0.402033693247289 1804 688787
SGTC_2714 st079313 56.9 µM 0.246416811177121 0.431641640540089 no 1413 0.402679796975615 1863 2939799
SGTC_2489 cantharidin 73.42 µM 0.246163592892569 0.431736095906588 no 1414 0.402777798588251 1786 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1779 st039427 55 µM 0.244612573137428 0.432314741546162 no 1415 0.403378213909048 2045 1124498
SGTC_2793 7325131 81.82 µM 0.243472476123438 0.432740175136175 no 1416 0.403819702278618 1890 4176441
SGTC_3258 9138477 49.47 µM 0.242483573345439 0.433109252920778 no 1417 0.404202741845509 1899 4970355
SGTC_748 act1.228 77.9 µM 0.242394345221932 0.433142557469825 no 1418 0.404237307806721 1806 4421505 YNR035C ARC35
SGTC_3041 9091929 49.47 µM 0.242096394115853 0.433253771666345 no 1419 0.40435273609463 1930 25236887
SGTC_3303 9125618 40.5795 µM 0.241395962941008 0.433515237683158 no 1420 0.404624120680148 1929 22695467
SGTC_2979 9012552 45.46 µM 0.240621430772165 0.433804398954492 no 1421 0.404924269386969 2036 17100905
SGTC_1761 st044296 37 µM 0.240411363191431 0.433882831002726 no 1422 0.405005684969675 1866 1826700
SGTC_1689 st020265 53.493 µM 0.238278064006854 0.434679478869959 no 1423 0.405832716909337 2007 5758320 YPR016C TIF6
SGTC_928 2764-0428 58.7 µM 0.238220183294804 0.434701097245353 no 1424 0.405855161830237 1913 662578
SGTC_780 0109-0199 192 µM 0.237373350533552 0.435017410540321 no 1425 0.406183581087081 2014 610414
SGTC_2898 9056270 58.44 µM 0.236687340268542 0.435273683099256 no 1426 0.40644967847111 1909 19154699
SGTC_2245 6637752 200 µM 0.236445724589886 0.435363949844058 no 1427 0.406543409375859 2012 681890
SGTC_1300 1094-0077 113 µM 0.234572976595181 0.436063715604779 no 1428 0.407270092960682 1855 5532636
SGTC_924 2046-0044 21.3 µM 0.233568466241396 0.436439140751619 no 1429 0.407660005465505 1937 3623589
SGTC_2433 5607874 27.82 µM 0.231515850106923 0.437206462079712 no 1430 0.408457036641542 1861 2252428
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.228682759176462 0.438265932716915 no 1431 0.409557747958157 1844 4330530
SGTC_766 1391-0721 126 µM 0.228490019764961 0.438338026253699 no 1432 0.409632657005362 1994 1020919 YIL115C NUP159
SGTC_59 0330-0160 1.33 µM 0.227961023461832 0.438535906072597 no 1433 0.409838270764827 1944 4293482
SGTC_2031 5180455 200 µM 0.227252360945884 0.438801017082794 no 1434 0.410113757218364 1909 29949
SGTC_2765 myclobutanil 7.74 µM 0.226234770742979 0.439181746093086 no 1435 0.410509414216042 1908 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1684 st024538 14.6195 µM 0.225206987433219 0.439566345949319 no 1436 0.410909126941614 1856 6732859
SGTC_3001 9076041 71.4286 µM 0.224713097553829 0.439751181463326 no 1437 0.411101237402346 1912 16004211
SGTC_3152 9099253 49.47 µM 0.224136190684284 0.439967102247373 no 1438 0.411325666333503 1968 25236131
SGTC_805 3852-0218 479 µM 0.223384755057558 0.440248371236237 no 1439 0.41161803413846 1854 6615355
SGTC_367 0335-0881 7.1 µM 0.220961626576965 0.441155574315662 no 1440 0.412561156013113 1980 23828853
SGTC_3191 9110352 49.47 µM 0.218824989934963 0.441955773179209 no 1441 0.413393189726843 1943 17122424
SGTC_2465 5809242 33.21 µM 0.218791769281868 0.441968216634946 no 1442 0.413406129356607 1959 2731748
SGTC_493 zm226600 134 µM 0.218547037687211 0.442059887480801 no 1443 0.413501456576053 1965 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1955 wogonin 32.4 µM 0.21802559849202 0.442255216994435 no 1444 0.413704583224671 2004 5281703 A flavanone.
SGTC_2340 7987427 183.45 µM 0.217813567549394 0.442334647149207 no 1445 0.413787186490075 1946 2239331
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.215917451988111 0.443045064811413 no 1446 0.414526046617581 1966 165521
SGTC_1719 st032227 49.2 µM 0.215426087125136 0.443229194466627 no 1447 0.414717566428535 1854 3125804
SGTC_1372 2752-0194 270 µM 0.215275747494662 0.443285533840543 no 1448 0.414776168520494 1921 823334
SGTC_563 tetrahydrosecaminediol 614 µM 0.215266545311276 0.443288982371373 no 1449 0.414779755575073 2035 334274 A psychoactive constituent of the cannabis plant.
SGTC_558 k064-0027 21.3 µM 0.213790766069096 0.443842088069065 no 1450 0.41535511304659 1973 5088526
SGTC_3222 9128301 49.47 µM 0.213234143603922 0.444050732471023 no 1451 0.415572168937028 1911 4911358
SGTC_2203 7227154 166.4 µM 0.213144483980747 0.444084341941812 no 1452 0.415607134272675 2005 896304
SGTC_1451 4152-0210 104 µM 0.212953747398111 0.444155842080705 no 1453 0.415681519683396 2033 659563
SGTC_2903 5923464 63.88 µM 0.212476362972181 0.444334803929556 no 1454 0.415867708201954 2059 2876576
SGTC_1437 4092-1038 11.6 µM 0.212152288071846 0.444456299581213 no 1455 0.415994114011108 1943 3977136
SGTC_463 ikarugamyin 104 µM 0.2117241031186 0.444616834084215 no 1456 0.416161141398631 2023 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_491 tetrandrine 80.3 µM 0.211566221589245 0.444676029100019 no 1457 0.416222732017386 2007 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2305 7443522 69.23 µM 0.211553772996254 0.444680696542437 no 1458 0.416227588382574 1959 5415886
SGTC_789 1309-1135 70.6 µM 0.211095243808047 0.44485262159861 no 1459 0.416406475751583 1974 3092424
SGTC_597 k018-0003 82.8 µM 0.209033196645824 0.445625911876092 no 1460 0.417211161917601 2011 6786234
SGTC_1150 3909-7983 10.9 µM 0.208514681448788 0.445820393425987 no 1461 0.417413560212735 1914 23965914
SGTC_2995 9067767 71.4286 µM 0.207737102723665 0.44611206738 no 1462 0.417717122901616 1944 11673567
SGTC_668 1682-0499 62.6 µM 0.206579099007069 0.446546494797219 no 1463 0.418169292370881 1920 682214
SGTC_368 fentichlor 4.58 µM 0.206066011983572 0.446739000966638 no 1464 0.418369673745741 1898 7329 A pesticide.
SGTC_1895 st058434 18.3 µM 0.206059778075147 0.446741339956752 no 1465 0.418372108471195 2069 5393175
SGTC_247 mechlorethamine 29.705 µM 0.204944270222593 0.447159913206689 no 1466 0.418807833305229 1949 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_539 4859-0462 2.54 µM 0.204300710057422 0.447401423807868 no 1467 0.419059257564439 2070 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_870 0573-2213 57.6 µM 0.20419299552233 0.447441848046843 no 1468 0.419101342405752 2031 3916321
SGTC_984 1492-0255 2.91 µM 0.202657005300232 0.448018349747715 no 1469 0.419701565287027 1954 1585198
SGTC_3277 9138724 49.47 µM 0.202512371346462 0.448072640743253 no 1470 0.419758093919647 1970 15943418
SGTC_1264 0783-0040 158 µM 0.20232131132581 0.448144360101687 no 1471 0.419832770221643 1877 2855798
SGTC_156 3474-0145 5.642 µM 0.202033979922359 0.448252220623432 no 1472 0.419945079876152 2081 2265471
SGTC_1962 st076595 64.5 µM 0.199124309996785 0.449344687550482 no 1473 0.421082752683265 1942 279619
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.198461587386423 0.449593567898883 no 1474 0.421341967894495 1923 6857784
SGTC_94 0334-0113 514.748 µM 0.197896370211679 0.44980584650761 no 1475 0.421563072084311 1862 6795178
SGTC_901 1112-0062 60.1 µM 0.196428128859062 0.450357340868529 no 1476 0.422137540724164 1954 1908457
SGTC_1845 st056753 3.01 µM 0.196110319225636 0.450476727784018 no 1477 0.42226190975799 1871 5375839
SGTC_2360 9040895 200 µM 0.196037418462087 0.450504113984177 no 1478 0.42229043924255 1927 4914414
SGTC_1972 st070201 17.4 µM 0.195989601941422 0.45052207706265 no 1479 0.422309152308972 2070 2829099
SGTC_2325 6158266 200 µM 0.195844232264654 0.450576688243692 no 1480 0.422366044024852 1946 3623240
SGTC_133 0724-0033 378.92 µM 0.194069943041031 0.451243312463047 no 1481 0.423060558074534 2072 280309
SGTC_3125 9127534 49.47 µM 0.192803369096342 0.451719265494051 no 1482 0.42355648241976 2100 1639235
SGTC_1490 4089-0339 670 nM 0.19120336546002 0.45232061383642 no 1483 0.42418313350224 2067 742542
SGTC_2172 5754775 163.918 µM 0.190958861730053 0.452412518242867 no 1484 0.424278911791412 1915 2263357
SGTC_1638 st008370 60.6 µM 0.19072984403872 0.452498604048004 no 1485 0.424368627864169 2038 24207134
SGTC_1352 1496-0991 99 µM 0.189186390437448 0.453078833183853 no 1486 0.424973366955327 1941 3000039
SGTC_821 1114-0266 29.2 µM 0.188696793352007 0.453262907970149 no 1487 0.425165232487391 1956 3123235
SGTC_387 norethindrone acetate 66.7 µM 0.188316478086345 0.453405902786518 no 1488 0.42531428439826 1939 541197
SGTC_3016 9080866 49.47 µM 0.188140219665346 0.453472176277011 no 1489 0.42538336664173 2000 17066299
SGTC_2893 9048488 25.97 µM 0.18790075145459 0.453562218840531 no 1490 0.425477226827475 1908 6467338
SGTC_835 0312-0010 67.2 µM 0.187095244218237 0.453865115519528 no 1491 0.4257929784429 1956 1626196
SGTC_2940 9060638 45.86 µM 0.186518433252814 0.454082031530022 no 1492 0.426019112422227 1958 4027022
SGTC_118 0083-0097 135.343 µM 0.186513436409983 0.454083910706819 no 1493 0.426021071499628 1946 5207356
SGTC_794 k038-0031 316 µM 0.185966132483068 0.454289743053155 no 1494 0.426235660183873 2015 6624242
SGTC_1651 st011928 86.1 µM 0.184930135203616 0.454679398803936 no 1495 0.426641917082707 2021 720198
SGTC_1521 st012942 49.4 µM 0.184839132972867 0.454713628340739 no 1496 0.426677606503996 2110 24207259
SGTC_3059 1327-0034 3 µM 0.181878505117605 0.455827419516614 no 1497 0.427839036782952 1953 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1936 st074407 74.3 µM 0.181008694908502 0.456154709375939 no 1498 0.428180375600457 1901 809813
SGTC_2262 9014885 67.46 µM 0.178092090664688 0.45725237730187 no 1499 0.429325326737882 2085 6457424
SGTC_2479 5617353 43.85 µM 0.177957824167194 0.457302916596524 no 1500 0.429378049202354 2051 2731746
SGTC_2666 tannic acid 100 µM 0.177480336896128 0.457482653319448 no 1501 0.429565554467147 2041 16134267 A thiamine antagonist.
SGTC_1946 st076057 65.1 µM 0.177352467099374 0.457530787804378 no 1502 0.429615770568012 1991 953009
SGTC_1178 0988-0033 191 µM 0.177159505184027 0.457603426327459 no 1503 0.429691551330136 2030 5392207
SGTC_985 1493-0307 8.71 µM 0.175615950471841 0.458184532354073 no 1504 0.430297835222424 2119 3278274
SGTC_2311 7694451 200 µM 0.175506963559995 0.458225566331144 no 1505 0.43034064978766 2022 2163142
SGTC_1723 st034307 2.5525 µM 0.173467655114909 0.458993455166062 no 1506 0.431141924956802 1979 867466
SGTC_772 k072-0172 35.3 µM 0.173267512752259 0.459068825813028 no 1507 0.431220579251419 1875 5861980
SGTC_166 k072-0058 166.424 µM 0.172949877767279 0.459188445459259 no 1508 0.43134541277397 2150 5846229
SGTC_1196 1588-0294 184 µM 0.172009079805589 0.459542766607511 no 1509 0.431715195370605 1964 6144269
SGTC_2127 5253358 187.912 µM 0.170424378675732 0.460139665586224 no 1510 0.432338200584626 1980 20612
SGTC_139 0099-0334 718.624 µM 0.169006506568431 0.460673802365313 no 1511 0.432895761760834 2148 97690
SGTC_2896 9052656 71.43 µM 0.168982974767715 0.460682667800186 no 1512 0.432905016489091 2081 6469436
SGTC_3005 9076496 71.4286 µM 0.168890643437698 0.460717453146366 no 1513 0.432941329465871 2132 21368410
SGTC_1100 amiodarone 5.07 µM 0.168457774376587 0.460880538307357 no 1514 0.433111580028173 2133 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_707 0865-0008 204 µM 0.168288214041409 0.46094442264108 no 1515 0.433178272731816 2040 723043
SGTC_98 0074-0023 107.663 µM 0.167825223264444 0.461118866309953 no 1516 0.433360389317286 1956 3563821
SGTC_70 0141-0289 43.283 µM 0.167380918541641 0.461286276563275 no 1517 0.433535169083703 2011 352408
SGTC_1015 4130-4525 82 µM 0.166732386692222 0.461530650174242 no 1518 0.433790310662527 1926 1363237
SGTC_2001 4023502 57.655 µM 0.166371628357501 0.461666593996259 no 1519 0.433932250030055 2033 108941 YCR052W RSC6
SGTC_2158 5657123 3.6195 µM 0.166129568530334 0.46175781141537 no 1520 0.434027492575603 2125 2858827
SGTC_1903 st060211 78.3 µM 0.165998399670019 0.461807241709305 no 1521 0.434079104789395 2111 688960
SGTC_1709 st033179 39.1045 µM 0.165806948565068 0.461879390108259 no 1522 0.434154438827509 2099 573381
SGTC_3225 9130819 49.47 µM 0.162677061683172 0.463059064974192 no 1523 0.435386354254014 2099 4547121
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.162141022023877 0.463261134710948 no 1524 0.435597401338173 2071 5377381
SGTC_2388 9080168 200 µM 0.161707868727825 0.46342442652034 no 1525 0.435767953876848 1939 15943073
SGTC_2282 7944268 200 µM 0.161515849277345 0.463496816730553 no 1526 0.435843564662495 2085 2970414
SGTC_1192 1488-0095 21.4 µM 0.161237403660473 0.463601791246697 no 1527 0.435953211323675 2018 915875
SGTC_1573 oleylamine 1.06 µM 0.161118316303514 0.463646688176202 no 1528 0.436000107194565 2000 5356789 An amine of the fatty acid oleic acid.
SGTC_2999 9069765 71.4286 µM 0.160161903322373 0.464007280610898 no 1529 0.436376769338471 2064 2097066
SGTC_39 0986-0283 58.349 µM 0.15901562252064 0.464439497055648 no 1530 0.436828282725152 2129 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3090 9117696 49.47 µM 0.158819084335072 0.464513607939198 no 1531 0.43690570626321 2112 7923821
SGTC_538 2922-0838 53.3 µM 0.158792024406342 0.464523811830026 no 1532 0.436916366342467 2139 777039
SGTC_2746 daunorubicin 9.88 µM 0.157909164618128 0.46485673769487 no 1533 0.437264188176496 2118 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1963 st076565 50.3 µM 0.156849341770126 0.465256428692081 no 1534 0.437681792485536 2041 4914280
SGTC_1297 1068-0111 14.1 µM 0.15601151061418 0.465572424790503 no 1535 0.438011974081787 2012 767057
SGTC_2884 9058502 51.95 µM 0.155507152004804 0.465762658983191 no 1536 0.438210758023208 2035 6471554
SGTC_346 4513-0042 7.16 µM 0.155438368581713 0.465788603350892 no 1537 0.438237868990672 2033 2827372
SGTC_2869 9037858 32.47 µM 0.155310345455639 0.465836892684761 no 1538 0.438288330042651 2169 27187042
SGTC_3007 9078383 71.4286 µM 0.154419513992086 0.46617292131759 no 1539 0.438639484127956 2016 6496995
SGTC_2600 tangeritin 87.95 µM 0.154240990694931 0.466240264617432 no 1540 0.438709861490809 2041 68077 A bioactive flavone.
SGTC_2333 9017922 200 µM 0.153303357098171 0.466593978484114 no 1541 0.43907952669453 2119 3163164
SGTC_2612 dictamnine 15.46 µM 0.152813418064921 0.466778814104667 no 1542 0.439272707966952 2021 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1340 1486-1359 257 µM 0.151848171605368 0.467142986313978 no 1543 0.439653343594955 2035 4309068
SGTC_2049 5262831 67.185 µM 0.151143307791792 0.467408937666736 no 1544 0.439931335106417 2028 763417
SGTC_1359 1582-0056 520 nM 0.150537402077642 0.467637562886297 no 1545 0.440170322172166 2096 3661189
SGTC_1071 trifluoperazine 6.31 µM 0.150512945426275 0.467646791291442 no 1546 0.44017996905433 2093 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1942 st076330 65.2 µM 0.150259495302755 0.467742428482575 no 1547 0.440279944089729 2093 24208414
SGTC_1885 st057546 99.9 µM 0.150181843454916 0.467771730102223 no 1548 0.440310575124038 2136 702008
SGTC_1951 sophoraflavanone G 9.2 µM 0.150041426486465 0.467824716336769 no 1549 0.440365965787873 1926 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3332 9141069 11.198 µM 0.15001060897963 0.467836345375479 no 1550 0.440378122609901 1994 17332883
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.149871064885561 0.467889002920519 no 1551 0.440433170359139 2106 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2175 5807670 165.306 µM 0.148139762788905 0.468542363416859 no 1552 0.441116234727985 2130 241186
SGTC_2773 thioridazine 9.09 µM 0.147559519777017 0.468761355143765 no 1553 0.441345201913058 2179 5452 An antipsychotic.
SGTC_2239 6685329 187.64 µM 0.147322339069936 0.468850873143721 no 1554 0.441438800414994 2010 805680
SGTC_1687 st020778 55.3625 µM 0.146223747465144 0.469265529880664 no 1555 0.441872379638896 2063 4259299
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.146048930086267 0.46933151672603 no 1556 0.441941380944801 2027 279621
SGTC_2592 piperlongumine 83.33 µM 0.145733947384071 0.469450412721885 no 1557 0.442065710660022 2007 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1231 0242-0792 125 µM 0.145516848106401 0.469532362411047 no 1558 0.442151407233011 2015 3707635
SGTC_2575 plumbagin 510 nM 0.144447648890019 0.469935977836058 no 1559 0.442573496466453 1984 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2922 7999257 32.47 µM 0.143567360984046 0.470268303732574 no 1560 0.442921057878352 2133 2988377
SGTC_3238 9133470 49.47 µM 0.143417580231219 0.470324850963356 no 1561 0.442980199740341 2162 3534688
SGTC_2831 7999036 19.48 µM 0.141646673840843 0.470993472255672 no 1562 0.443679549098611 2150 2988270
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.140069916254942 0.471588859834994 no 1563 0.444302374791067 2023 442882
SGTC_3142 9086498 49.47 µM 0.139510216511919 0.471800219187457 no 1564 0.444523491639875 2174 25236367
SGTC_2065 5221596 34.26 µM 0.139185969617385 0.471922668143673 no 1565 0.444651597603562 2088 788581
SGTC_3122 9126309 49.47 µM 0.138726260689416 0.472096277678079 no 1566 0.444833232858257 2186 17591206
SGTC_2617 dihydrotanshinone i 20.83 µM 0.137704268886811 0.472482252846687 no 1567 0.445237072730757 2075 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.13593170455672 0.47315175746157 no 1568 0.445937635738646 2048 5282362
SGTC_456 gingerol 170 µM 0.13592556376104 0.473154076997515 no 1569 0.445940063033707 2108 442793 A herb.
SGTC_1068 loratadine 26.9 µM 0.135191827651346 0.473431234465176 no 1570 0.446230104182463 2038 3957 A H1 histamine antagonist.
SGTC_2199 6590217 200 µM 0.134240339225776 0.47379066363686 no 1571 0.446606264241014 2134 703109
SGTC_2962 9082311 13.18 µM 0.133873221768509 0.473929349681856 no 1572 0.446751412790176 2072 16459453
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.132166712412743 0.474574059320703 no 1573 0.447426214876573 2076 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2757 clomiphene 4.22 µM 0.132086856419168 0.474604230110088 no 1574 0.447457795939144 2188 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2972 9093619 59.92 µM 0.131420488672576 0.474855999478648 no 1575 0.447721340805347 1952 25236256
SGTC_3062 9077494 49.47 µM 0.131082010694388 0.474983888251833 no 1576 0.44785521587513 2123 16459633
SGTC_2505 galangin 7.89 µM 0.129911103170234 0.475426317708651 no 1577 0.448318379838409 2003 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2122 5258151 111.688 µM 0.129380633296006 0.475626766685131 no 1578 0.448528235632205 2085 2173356
SGTC_662 k832-1615 104 µM 0.129196314832281 0.475696416662637 no 1579 0.448601156055396 2105 5878478
SGTC_2280 7785178 200 µM 0.128318470938045 0.476028145117235 no 1580 0.448948474123519 2080 2954328
SGTC_1296 1068-0102 11.9 µM 0.127749546348388 0.47624314493495 no 1581 0.4491735894862 2154 767053
SGTC_879 0831-1030 162 µM 0.126228749228572 0.476817896545613 no 1582 0.449775427390724 2103 1549252
SGTC_586 0957-0265 8.15 µM 0.126135425773121 0.476853167662759 no 1583 0.449812362847624 2193 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_811 0416-0114 265 µM 0.123186525754159 0.477967781115061 no 1584 0.450979697595003 2048 6612453
SGTC_1652 st011932 78 µM 0.122251632810155 0.478321184613742 no 1585 0.451349868005699 2181 1551076
SGTC_421 streptovitacin 30 mM 0.121114520004989 0.478751053189847 no 1586 0.451800164269433 2060 91467 include heat shock
SGTC_1237 0330-0133 46.1 µM 0.120660709604229 0.478922616388373 no 1587 0.451979890372428 2114 X1237 YHR072W ERG7
SGTC_1747 st037496 66.6 µM 0.120085781992517 0.479139973599489 no 1588 0.452207597604568 2128 723305
SGTC_1094 duloxetine 25.4 µM 0.119722234555721 0.479277419598652 no 1589 0.452351593207563 2110 60834 A selective serotonin reuptake inhibitor.
SGTC_1463 k081-0032 34.1 µM 0.119687714380932 0.479290470733385 no 1590 0.452365266449175 2133 977755
SGTC_1653 st012112 65 µM 0.118720217095871 0.479656263998114 no 1591 0.452748509449803 2187 720429
SGTC_1064 honokiol 6.76 µM 0.117483194665789 0.480123984773387 no 1592 0.453238580265422 2089 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2292 7671323 168.05 µM 0.117250009236126 0.480212155758542 no 1593 0.453330969270365 2087 937504
SGTC_3029 9088683 49.47 µM 0.117119004017611 0.480261691264697 no 1594 0.453382875173289 2132 25236615
SGTC_1029 k015-0030 64.7 µM 0.117058395012947 0.480284608758172 no 1595 0.453406889487037 2101 2208316
SGTC_3269 9137823 49.47 µM 0.115441064063686 0.480896178212615 no 1596 0.454047766048649 2049 17682936
SGTC_3353 9151644 39.2805 µM 0.114450293949803 0.481270845381543 no 1597 0.454440423538751 2132 4909158
SGTC_399 oxolinic acid 75 µM 0.113515155759579 0.481624490102763 no 1598 0.45481107409263 2074 4628 A DNA gyrase inhibitor.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.112791290113305 0.481898247036093 no 1599 0.455098011879861 2192 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_856 0433-0016 11.3 µM 0.112408673905594 0.482042951156561 no 1600 0.455249689068108 2112 3911780
SGTC_2217 6934799 96.0675 µM 0.112103934519222 0.482158204227164 no 1601 0.45537049889909 2207 675606
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.111170437099089 0.482511264134262 no 1602 0.455740597033882 2108 2724 A muscle relaxant with antifungal properties.
SGTC_2356 9061756 188.97 µM 0.110672436943001 0.482699619386787 no 1603 0.455938051906359 2196 20104043
SGTC_1416 3966-0321 25.3 µM 0.11063610649559 0.482713360559407 no 1604 0.455952457195552 2137 582530 YLR208W SEC13
SGTC_2485 5633444 17.78 µM 0.109630395974362 0.483093755983649 no 1605 0.456351251723078 2083 5724239
SGTC_831 k061-1017 217 µM 0.108546678065043 0.483503673788248 no 1606 0.45678102773947 2177 1240153
SGTC_1203 3992-3522 103 µM 0.108345401253751 0.483579808954676 no 1607 0.456860854781899 2243 5322312
SGTC_1295 1013-0063 9.78 µM 0.108256229022129 0.48361353952307 no 1608 0.456896221337609 2229 6826038
SGTC_3166 9102297 49.47 µM 0.107455478546514 0.483916439139013 no 1609 0.457213821861926 2098 25237072
SGTC_2444 5485484 36.41 µM 0.107211019672221 0.484008912373489 no 1610 0.457310786692622 2174 6790631
SGTC_1483 3453-0561 55.9 µM 0.104503202912118 0.485033274306361 no 1611 0.458385013321121 2189 4546991
SGTC_3216 9129716 49.47 µM 0.1043905036168 0.485075910423453 no 1612 0.458429729262211 2145 8056934
SGTC_1280 0880-0253 10.1 µM 0.103800319131395 0.485299190325105 no 1613 0.458663906604245 2132 6836607
SGTC_1328 1441-0025 69.2 µM 0.103369830659241 0.485462056588446 no 1614 0.458834727748823 2200 4562601
SGTC_2012 4023501 200 µM 0.10285872629502 0.485655425326452 no 1615 0.459037547768547 2116 3477460
SGTC_2439 5492030 7.2 µM 0.10259649227117 0.485754638983082 no 1616 0.459141613455906 2236 5722370
SGTC_2329 6138490 200 µM 0.102230353223054 0.485893165554633 no 1617 0.4592869177874 2084 720019
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.102090889871668 0.485945931148134 no 1618 0.459342266030796 2197 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3089 9117425 49.47 µM 0.100942848220626 0.486380298963332 no 1619 0.459797914418604 2064 9401657
SGTC_636 0kpi-0074 126 µM 0.100410203748826 0.48658183342102 no 1620 0.460009334644114 2127 616434
SGTC_1020 4335-0961 93.3 µM 0.100332928463684 0.486611072032844 no 1621 0.460040008123539 2027 669075
SGTC_2781 5567276 71.43 µM 0.0997435623496377 0.486834072557322 no 1622 0.460273957605632 2193 2853274
SGTC_474 dl-dihydrosphingosine 5 µM 0.0994136047361267 0.486958921579331 no 1623 0.46040494062838 2206 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2424 5537928 59.2 µM 0.0990604195896403 0.487092560827295 no 1624 0.460545149027802 2139 5382802
SGTC_676 falcarinol 140 µM 0.0989915774670831 0.487118609683991 no 1625 0.460572478732544 2235 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3284 9108171 64.8615 µM 0.0983843404981288 0.487348381678252 no 1626 0.460813554411196 2133 8687505
SGTC_1817 st052116 64.4 µM 0.0983686967709336 0.487354301153636 no 1627 0.460819765228607 2210 4361398
SGTC_1717 st033143 58.0435 µM 0.0981547255343169 0.487435266630621 no 1628 0.46090471629325 2225 674616
SGTC_1851 st056236 18.9 µM 0.097100684647224 0.487834117094393 no 1629 0.461323218581309 2243 5393171
SGTC_3175 9106517 49.47 µM 0.0965583244596794 0.488039351672256 no 1630 0.461538577023209 2134 41468073
SGTC_1363 1636-0063 10.4 µM 0.0952579232668968 0.488531449428304 no 1631 0.462054981495031 2190 6072185
SGTC_401 neomycin 50 µM 0.0947735935333304 0.488714733964997 no 1632 0.462247330874356 2141 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2566 crystal violet carbinol 226 nM 0.0947243519214459 0.488733368565257 no 1633 0.462266887454672 1996 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1389 3405-0187 19 µM 0.0945620148997517 0.488794802258386 no 1634 0.462331361152479 2117 799890
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0945266558518794 0.488808183325783 no 1635 0.462345404467197 2234 77254
SGTC_318 1488-0629 67.2 µM 0.0941623531463462 0.488946048601852 no 1636 0.462490094847219 2125 3662576
SGTC_1398 3558-0053 112 µM 0.0938817528881557 0.489052238755874 no 1637 0.462601544448038 2160 4532369
SGTC_771 0250-0039 27.3 µM 0.0926664655932035 0.489512160042979 no 1638 0.463084269461221 2119 3005115
SGTC_2132 5317594 122.667 µM 0.0918493197175745 0.489821413961108 no 1639 0.463408879087057 2165 794577
SGTC_1922 5578187 25 µM 0.0901948270683167 0.490447585495623 no 1640 0.464066197487748 2243 1350412
SGTC_1822 st052468 42 µM 0.0900912249946733 0.490486796302582 no 1641 0.464107361151904 2208 2873678
SGTC_452 diindolylmethane 8 µM 0.0894695786990754 0.490722075874717 no 1642 0.464354364641623 2200 3071 Inhibits expression of several cancer promoting factors.
SGTC_2251 lansoprazole 556 µM 0.0890589691096772 0.490877484429207 no 1643 0.46451752283855 2051 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_217 ketoconazole 989 nM 0.0884002946166858 0.491126784097551 no 1644 0.46477926357197 2226 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_3256 9138902 49.47 µM 0.0876590606442351 0.491407335587767 no 1645 0.465073829593508 2258 17228773
SGTC_1374 2889-5571 141 µM 0.0850575822862918 0.492392008324363 no 1646 0.466107806239462 2167 2853281
SGTC_307 1501-1223 22.3 µM 0.0847784731743861 0.492497655396996 no 1647 0.466218753916853 2194 2830329
SGTC_2129 girgensonine 121.053 µM 0.0845810228425901 0.492572393689246 no 1648 0.466297243286998 2196 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1702 st027038 51 µM 0.0840189658715069 0.492785143183784 no 1649 0.466520676249722 2162 5521182
SGTC_2037 5169046 200 µM 0.0834073370947827 0.493016658900624 no 1650 0.46676382734222 2189 5718022
SGTC_1149 3909-7961 23.3 µM 0.0831166848054904 0.493126678381228 no 1651 0.466879379597307 2100 735261
SGTC_1697 st025554 27.742 µM 0.0815050179617713 0.493736745620705 no 1652 0.467520167200827 2251 1269519
SGTC_1104 tacrolimus 29.8 µM 0.0811778407927448 0.49386059443639 no 1653 0.467650260915622 2265 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2241 6772625 37.8075 µM 0.0788384175623745 0.494746170302802 no 1654 0.46858057316803 2283 2285411
SGTC_1475 4092-1048 11.7 µM 0.0786085859442494 0.494833173272169 no 1655 0.468671979039479 2166 2881759
SGTC_565 1418-0001 44.5 µM 0.078533493582467 0.494861599607909 no 1656 0.468701844230095 2258 2862145
SGTC_3117 9124945 49.47 µM 0.0758914069065643 0.495861781380213 no 1657 0.469752746719715 2187 17592065
SGTC_191 3914-0123 66.505 µM 0.0757623847928153 0.49591062438848 no 1658 0.469804071332635 2176 3144412
SGTC_2846 9008642 19.48 µM 0.0754190684291687 0.496040591583788 no 1659 0.469940644001827 2144 2992898
SGTC_3070 9117005 49.47 µM 0.0750394255975175 0.496184311158688 no 1660 0.470091671606881 2284 8779016
SGTC_288 1315-0019 35.1 µM 0.0750105003941471 0.496195261255419 no 1661 0.470103178662718 2222 6811474
SGTC_909 3448-9333 149 µM 0.074734662844067 0.496299684098992 no 1662 0.470212913909547 2224 3344074
SGTC_1476 4112-3294 3.34 µM 0.0739719911912116 0.496588407300882 no 1663 0.470516335988405 2224 704369
SGTC_114 0364-0001 490.298 µM 0.0729019020362994 0.496993511958271 no 1664 0.470942090183582 2131 4003655
SGTC_1724 st037281 8.293 µM 0.0728148175619669 0.497026479751632 no 1665 0.47097673977428 2237 574124 YDL195W SEC31
SGTC_21 0849-0113 22.993 µM 0.072294200155444 0.497223571637638 no 1666 0.471183890113212 2251 1560156
SGTC_934 2950-0684 338 µM 0.070821817947565 0.497780979841567 no 1667 0.471769783606081 2285 1121253
SGTC_935 2996-0153 430 µM 0.0707964010626177 0.497790602099107 no 1668 0.47177989808766 2295 23738523
SGTC_317 4495-0002 170 µM 0.0703253441888067 0.497968933799782 no 1669 0.471967355348481 2145 15991618
SGTC_1969 st069479 40.1 µM 0.0697394910222593 0.498190725396902 no 1670 0.472200504497182 2286 3895485
SGTC_1527 coumarin 137 µM 0.0695525888578724 0.498261482717612 no 1671 0.472274887054876 2227 323 A hepatotoxic, DNA x-linker.
SGTC_581 0958-0271 211 µM 0.0694037481014512 0.498317830810224 no 1672 0.472334122781108 2266 4591145
SGTC_2469 5655019 90.81 µM 0.0693787615641777 0.49832729020995 no 1673 0.472344066996996 2267 2788239
SGTC_1367 1812-0510 76.9 µM 0.0688316971760906 0.498534397994581 no 1674 0.47256179360735 2245 1142582 YDR527W RBA50
SGTC_1130 3454-2858 15.9 µM 0.0667214077720108 0.499333315132903 no 1675 0.473401745674218 2132 715628 YIL048W NEO1
SGTC_2931 9014674 55.67 µM 0.0666875844067846 0.499346120073354 no 1676 0.473415209258288 2266 2996810
SGTC_1811 st050069 61.5 µM 0.0653036312246704 0.499870061213245 no 1677 0.473966125609456 2299 3877702
SGTC_2839 9003951 25.97 µM 0.0652036806567235 0.499907900818056 no 1678 0.474005915313633 2330 2990634
SGTC_1523 st012844 44.7 µM 0.0647171340709102 0.499907900818056 no 1679 0.474199610202617 2168 4274103
SGTC_2809 7964133 12.99 µM 0.0647101815278095 0.499905268702082 no 1680 0.474202378064239 2234 1253665
SGTC_679 0422-0091 41.4 µM 0.0634833363806936 0.499440805917262 no 1681 0.474690814059241 2274 627384 YHR062C RPP1
SGTC_264 promethazine 12.5 mM 0.0602038214112545 0.498199242563305 no 1682 0.475996651095872 2306 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1772 st048439 82.2 µM 0.0598412365805512 0.498061975543954 no 1683 0.476141041182507 2178 2927068 YDL195W SEC31
SGTC_1677 st019204 53.9 µM 0.059092882563575 0.49777866513774 no 1684 0.476439063814139 2149 3945625
SGTC_140 0062-0056 502.533 µM 0.058839188238479 0.49768262228137 no 1685 0.476540097407114 2299 3758964
SGTC_1119 parthenolide 318.541 nM 0.0583825385653145 0.497509745524515 no 1686 0.47672196162606 2246 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_375 3970-0961 9.27 µM 0.0578653681905168 0.497313957629054 no 1687 0.476927934529614 2245 2898222
SGTC_3345 9148410 3.559 µM 0.0575482657698976 0.497193910823031 no 1688 0.477054229630536 2282 4903596
SGTC_2142 5622915 118.518 µM 0.0566678946982787 0.496860626384576 no 1689 0.4774048746107 2250 5322196
SGTC_2206 7254556 146.969 µM 0.0565429050674614 0.496813308896945 no 1690 0.477454658437135 2296 4398905
SGTC_527 4476-4215 268 µM 0.0558511902107847 0.496551446329837 no 1691 0.477730177331055 2161 4418754
SGTC_1685 st024049 53.0905 µM 0.055783045362127 0.496525648805776 no 1692 0.477757320875876 2241 1941139
SGTC_394 menadione 8.33 µM 0.0548867098739252 0.49618632541084 no 1693 0.478114359951305 2323 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_965 1291-5240 308 µM 0.054689980676155 0.496111850510716 no 1694 0.478192725839745 2297 2834598
SGTC_2873 9040596 71.43 µM 0.0543486741004669 0.495982643916664 no 1695 0.478328685252524 2160 6463863
SGTC_3131 9127911 49.47 µM 0.0541861342442389 0.495921112225096 no 1696 0.478393433862378 2263 45595681
SGTC_2791 5663188 71.43 µM 0.0541142953322575 0.495893916650637 no 1697 0.478422051454062 2292 54690634
SGTC_782 0083-0095 30.5 µM 0.0539625267237052 0.495836462690628 no 1698 0.478482510030267 2337 3591729 An indicator and reagent.
SGTC_2987 9018338 71.43 µM 0.0529037551759759 0.495435653563738 no 1699 0.478904296195329 2328 5055682
SGTC_2290 7904846 200 µM 0.0528655737663405 0.495421199672405 no 1700 0.478919507088258 2264 2962154
SGTC_1041 0206-0046 107 µM 0.0525559422239007 0.495303986291075 no 1701 0.479042860717962 2207 50494
SGTC_1176 0848-0131 83.3 µM 0.0513379209522106 0.494842899081538 no 1702 0.479528125690003 2310 6769040
SGTC_2889 9059656 51.95 µM 0.0512146525702019 0.494796235677112 no 1703 0.479577238052408 2271 3949838
SGTC_1931 st074438 57.1 µM 0.0497940466372457 0.494258468775836 no 1704 0.480143255447543 2318 2787313
SGTC_3348 9149464 3.537 µM 0.049486995630045 0.494142236705836 no 1705 0.480265600243294 2326 1951442
SGTC_1777 st045864 34.765 µM 0.0487066074975243 0.493846828347981 no 1706 0.480576555053007 2318 4691462
SGTC_535 2293-4129 48.2 µM 0.0483437766628164 0.493709483394232 no 1707 0.480721133293793 2327 396118 YIL048W NEO1
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.0475283516908584 0.493400817486925 no 1708 0.48104606724069 2309 6710655
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0467017049094933 0.493087907779471 no 1709 0.48137548575451 2302 2333 A French combination drug.
SGTC_519 k048-0011 62.8 µM 0.0459212912756419 0.492792502554763 no 1710 0.481686492046353 2234 6836379
SGTC_2534 helenine 20.12 µM 0.0445446316001993 0.492271413680206 no 1711 0.482235138195423 2295 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1239 0337-0584 35.4 µM 0.0436418745737184 0.49192971204495 no 1712 0.482594936197621 2321 914301 YML130C ERO1
SGTC_1387 3342-1166 1.8 µM 0.0429545072726533 0.491669541311362 no 1713 0.482868899146659 2269 3418228
SGTC_2915 7971052 15.16 µM 0.042309433089237 0.491425381880289 no 1714 0.483126012751724 2335 5741558
SGTC_87 0100-0052 35.5 µM 0.0422436858724764 0.491400496854557 no 1715 0.483152218666822 2321 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3159 9100096 49.47 µM 0.0418438395826307 0.491249157557123 no 1716 0.483311593332631 2337 25236875
SGTC_2555 cholic acid 100 µM 0.0417613889685002 0.491217950675933 no 1717 0.483344457641586 2264 6708657 Influences liver metabolism.
SGTC_3067 9117431 49.47 µM 0.0416702528428178 0.491183456462413 no 1718 0.48338078407382 2285 17150885
SGTC_1547 harmine 94.2 µM 0.041381064108888 0.491074001534823 no 1719 0.483496054258724 2328 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2835 9006588 71.43 µM 0.0411333749118943 0.490980254284331 no 1720 0.483594783889061 2222 2345538
SGTC_2247 cerulenin 830 nM 0.0409263450035527 0.490901896446031 no 1721 0.483677307381355 2323 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1572 epiandrosterone 68.9 µM 0.0401576446334361 0.490610957524126 no 1722 0.483983722528771 2293 441302 A steroid.
SGTC_304 1310-0298 97 µM 0.0397595374032674 0.490460283228806 no 1723 0.484142417590057 2324 1550234
SGTC_678 1218-2179 85.9 µM 0.0382877315905606 0.489903251065912 no 1724 0.484729136193781 2348 6820081 YOR116C RPO31
SGTC_1726 st035556 14.5795 µM 0.0378727501178591 0.489746197155358 no 1725 0.484894569856074 2313 5919439
SGTC_1897 st060201 15 µM 0.0368853581773569 0.489372515184943 no 1726 0.485288207142645 2271 611878
SGTC_2690 usnic acid 100 µM 0.0368588760003134 0.48936249303841 no 1727 0.485298764823442 2334 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2267 7931562 200 µM 0.0368349666767536 0.489353444590806 no 1728 0.485308296790553 2324 934880
SGTC_2407 paclitaxel 400 µM 0.03645492819311 0.489209620336104 no 1729 0.48545980844591 2243 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2162 5663267 200 µM 0.0363101179471037 0.489154817765615 no 1730 0.485517541152934 2337 6456493
SGTC_1778 st046819 58.9 µM 0.0356811099182138 0.488916775833187 no 1731 0.485768316530752 2338 671715
SGTC_640 3381-0960 37.1 µM 0.0353045161580889 0.488774259494377 no 1732 0.48591846110198 2322 1745025
SGTC_3017 9080681 49.47 µM 0.0351738878277865 0.488724825468621 no 1733 0.485970541918863 2277 16451914
SGTC_799 1310-0557 151 µM 0.0351032375594182 0.488698089172166 no 1734 0.485998709902896 2257 5354492
SGTC_2480 5767542 37.17 µM 0.0340301858656714 0.488292018780556 no 1735 0.486426539897757 2331 2867358
SGTC_637 1181-0519 7.26 µM 0.0336881509899075 0.488162586507053 no 1736 0.486562913875481 2339 6252091 YGR060W ERG25
SGTC_2519 cryptotanshinone 88.04 µM 0.0323538120469442 0.487657660210164 no 1737 0.487094947916656 2340 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3071 9117417 49.47 µM 0.0323513694620077 0.487656735931143 no 1738 0.48709592185722 2342 45595590 YGL055W OLE1
SGTC_1587 estradiol valerate 56.1 µM 0.030731692888769 0.487043861918151 no 1739 0.487741757911513 2351 13791 A steroid.
SGTC_1469 k284-2957 126 µM 0.0292394793291579 0.48647924604298 no 1740 0.488336797365995 2315 23884841
SGTC_2513 baicalein 25.65 µM 0.0290681461881819 0.486414419628367 no 1741 0.488405120358325 2332 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1882 5615643 20 µM 0.0283995948426923 0.486161466840132 no 1742 0.488671723670422 2357 2253075
SGTC_1223 0764-0573 147 µM 0.0261531870873618 0.485311558377802 no 1743 0.48956757719457 2358 1609797
SGTC_1600 coumarin 106 71.1 µM 0.0258868237321163 0.485210786512859 no 1744 0.48967380483231 2328 100336 A hepatotoxic, DNA x-linker.
SGTC_1226 3909-7979 35.4 µM 0.0256265626411493 0.485112324198104 no 1745 0.489777599550352 2352 6615510
SGTC_2215 7188065 200 µM 0.0232334338234724 0.484206995902824 no 1746 0.490732034732684 2361 940217
SGTC_22 0964-0034 14.468 µM 0.0228844761550009 0.484074990789345 no 1747 0.490871211693815 2349 138402
SGTC_2423 st077119 87.2 µM 0.0221738792278888 0.483806188730724 no 1748 0.491154626911616 2353 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2107 5363541 170.161 µM 0.0216577155787615 0.483610940803179 no 1749 0.491360496966719 2370 244052
SGTC_2085 5307070 144.047 µM 0.0214831654911233 0.483544915066665 no 1750 0.491430116178404 2356 2840351
SGTC_1512 0259-0544 12.2 µM 0.0208750636656115 0.483314896541653 no 1751 0.491672659300601 2336 18476
SGTC_2374 9071832 200 µM 0.0206142409872411 0.483216240341038 no 1752 0.491776690107647 2375 17381698
SGTC_332 4112-0506 40.9 µM 0.0200807906765258 0.483014465921636 no 1753 0.491989461937958 2360 2790355
SGTC_88 0180-0332 8.668 µM 0.0183867119384802 0.482373719767725 no 1754 0.492665176494575 2379 3101745
SGTC_1255 0566-0045 221 µM 0.0182060293355907 0.482305383404089 no 1755 0.49273724636014 2339 2788469
SGTC_1727 st034309 9.9045 µM 0.0178505441474907 0.482170936090668 no 1756 0.492879041386064 2378 870305
SGTC_42 0133-0086 60.653 µM 0.0175154381693535 0.482044198212168 no 1757 0.493012708428847 2377 162923 Model of phenazepam hydroxylation.
SGTC_776 4476-4378 112 µM 0.0173998012491217 0.48200046447419 no 1758 0.493058833856153 2263 2892008
SGTC_3021 9087658 49.47 µM 0.0159605618246989 0.48145616422409 no 1759 0.493632927394499 2378 25237042
SGTC_1992 st073643 23.3 µM 0.0157276255941418 0.481368074218195 no 1760 0.493725843841909 2370 3161292
SGTC_3260 9137109 49.47 µM 0.0154445100094103 0.481261009000958 no 1761 0.493838776900528 2381 17478346
SGTC_1571 st070080 73.4 µM 0.0154146801854074 0.481249728398569 no 1762 0.493850675862048 2376 4315245
SGTC_278 4092-0821 23.9 µM 0.0153256226975735 0.481216050042158 no 1763 0.493886200462878 2357 877900
SGTC_2683 piperine 63.03 µM 0.0149862306841154 0.481087705353371 no 1764 0.494021582736337 2378 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_420 mitomycin C 81.9 mM 0.0137029383168187 0.480602432567481 no 1765 0.494533489615138 2381 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3048 9093155 49.47 µM 0.0128039800902733 0.480262511550228 no 1766 0.494892090551688 2389 25236002
SGTC_694 1315-0438 43.2 µM 0.0125835350080049 0.480179157337476 no 1767 0.494980028330276 2371 6793154
SGTC_2711 st079103 59.1 µM 0.0125094690307598 0.480151151866358 no 1768 0.495009574054574 2368 54693780
SGTC_808 0711-0032 135 µM 0.0124424006664188 0.480125792383503 no 1769 0.49503632837856 2383 4252555
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.0122091023607854 0.480037579671398 no 1770 0.495129393866696 2375 5282309
SGTC_497 capsazepine 133 µM 0.011953358644663 0.479940881220658 no 1771 0.495231413402266 2380 2733484 A calcium channel blocker.
SGTC_1438 4092-1045 4 µM 0.0114076183211611 0.479734537020855 no 1772 0.495449117437128 2378 1351342
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.0113128857829187 0.479698719237345 no 1773 0.495486907813345 2363 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1254 0550-0035 264 µM 0.0109412692737749 0.479558214932069 no 1774 0.495635152172596 2381 15121435
SGTC_1764 st044502 93.5 µM 0.0107079928544322 0.479470016860643 no 1775 0.495728210546974 2376 8407
SGTC_2188 6126565 140.678 µM 0.0103192530901103 0.479323042828142 no 1776 0.495883286703052 2378 874518
SGTC_1173 0443-0020 122 µM 0.0102715109702134 0.47930499276656 no 1777 0.495902332043852 2386 5331295
SGTC_2783 7738165 71.43 µM 0.0102099672329315 0.479281724732787 no 1778 0.495926883155339 2370 17201110
SGTC_351 caspofungin 25 nM 0.0101922306820686 0.479275019032478 no 1779 0.495933958647231 2374 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_265 mycophenolic acid 32.932 µM 0.00899090879610184 0.47882084613888 no 1780 0.496413194666163 2382 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2828 7998861 71.43 µM 0.00836758487902311 0.478585202505267 no 1781 0.496661855561141 2396 2988188
SGTC_2330 7979373 200 µM 0.00745826876532894 0.478241454792564 no 1782 0.497024608835677 2390 1863007
SGTC_2586 curcumin 80 µM 0.00716961969150211 0.478132340491245 no 1783 0.497139760075047 2389 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1155 4088-0394 48.2 µM 0.00507175810531855 0.477339362584791 no 1784 0.497976669930086 2393 2326248
SGTC_1783 st039459 87.517 µM 0.00424371852719223 0.477026393580411 no 1785 0.498307006334944 2398 729761
SGTC_793 0488-0545 106 µM 0.00212023674823256 0.476223859509883 no 1786 0.49915414855041 2394 292548
SGTC_2518 prenyletin 46.28 µM 0.00166229286635437 0.476050799884282 no 1787 0.49933684139861 2402 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_570 0987-0065 62.6 µM 0.00163155152350571 0.476039182715535 no 1788 0.499349105403396 2403 3104428
SGTC_233 rapamycin 362 pM 0 0.475422648054322 no 1789 0.5 2406 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0 0.475422648054322 no 1790 0.5 2399 6708561
SGTC_1032 k061-1018 98.7 µM -1.78667737613041e-05 0.475415896837387 no 1791 0.499992872188533 2407 4005393
SGTC_1051 3253-3903 78 µM -0.000122090130765676 0.475376514686606 no 1792 0.499951293084939 2404 5509239
SGTC_3032 9089427 49.47 µM -0.000347191911907421 0.475291457872718 no 1793 0.499861490469709 2400 17173707
SGTC_618 k072-0232 33.2 µM -0.000579519236547585 0.475203672000496 no 1794 0.499768805287176 2407 5872756 YGL099W LSG1
SGTC_2919 7978188 46.38 µM -0.000599429104121467 0.475196149027907 no 1795 0.499760862400584 2407 2980291
SGTC_153 4077-0274 519.67 µM -0.00100872539727058 0.475041497788112 no 1796 0.49959757685796 2406 3121976
SGTC_292 k038-0015 474 µM -0.00229514487502316 0.474555453068069 no 1797 0.499084370473582 2410 46368540
SGTC_599 1935-0052 86.5 µM -0.00288157081385354 0.47433389771457 no 1798 0.498850421159295 2410 9557311
SGTC_3040 9091894 49.47 µM -0.00440320168791515 0.473759053329838 no 1799 0.498243382353829 2408 25236966
SGTC_14 0354-0009 295 µM -0.0052833208176871 0.473426585242137 no 1800 0.497892269750585 2422 1713507
SGTC_2596 sinensetin 100 µM -0.00575505520638559 0.473248393526914 no 1801 0.497704077825878 2422 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2066 5222451 176 µM -0.00598690378836271 0.47316081760919 no 1802 0.497611585218134 2416 2281147
SGTC_578 3460-0051 92 µM -0.00656816997675792 0.472941262263904 no 1803 0.497379698131766 2421 2876744
SGTC_779 1360-0071 233 µM -0.00674187000974373 0.472875654034933 no 1804 0.497310403379113 2425 7566
SGTC_3108 9121785 49.47 µM -0.00821102848074245 0.47232076788669 no 1805 0.496724310381865 2415 17140271
SGTC_1529 apigenin 74 µM -0.00901079183968214 0.472018727945669 no 1806 0.496405262800724 2420 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3038 9091290 49.47 µM -0.00973080168899818 0.471746821604864 no 1807 0.496118033047093 2425 25236843
SGTC_2814 7977482 42.97 µM -0.0109959472829559 0.471269080796526 no 1808 0.495613340115076 2426 6456762
SGTC_2450 5739737 12.93 µM -0.0111147844202091 0.47122420795614 no 1809 0.495565933853683 2430 2262825
SGTC_2264 7948757 110.76 µM -0.0120256500240622 0.470880277757548 no 1810 0.495202575387303 2419 2971411
SGTC_2949 9072542 2.23 µM -0.0141149467084837 0.470091470810762 no 1811 0.494369137947383 2446 16457352
SGTC_1357 1503-1303 39.5 µM -0.0150554729093774 0.469736416421358 no 1812 0.493993962201228 2440 292895
SGTC_169 k015-0017 16.025 µM -0.0150844128817469 0.469725491785047 no 1813 0.493982418133578 2434 1840002
SGTC_1734 st037168 69.4 µM -0.0164026923603576 0.469227874833249 no 1814 0.493456565923005 2474 708907
SGTC_2551 apiole 73.87 µM -0.0165088605434292 0.469187801127149 no 1815 0.493414216680283 2432 10659 A possible DNA adduct former.
SGTC_1570 verbenone 133 µM -0.0167223752844014 0.469107209877048 no 1816 0.493329048380173 2441 29025 A natural terpanoid with antifungal properties.
SGTC_6 0844-0013 19.835 µM -0.0171585595280926 0.468942575844882 no 1817 0.493155061011888 2436 1584900
SGTC_2625 euphol 100 µM -0.0174763345436804 0.468822637710653 no 1818 0.493028306130986 2441 6708538 A triterpene alcohol.
SGTC_2956 9076196 2.52 µM -0.0179542519919705 0.46864226219271 no 1819 0.492837674571587 2431 16423868
SGTC_753 1322-0200 289 µM -0.0187077003673887 0.468357908928454 no 1820 0.492537142662953 2476 5403907
SGTC_1548 st061468 90.8 µM -0.018713091798169 0.468355874247253 no 1821 0.492534992169717 2443 390799
SGTC_1674 st016616 23.6 µM -0.0190729586658007 0.468220065351664 no 1822 0.492391451682094 2439 625830
SGTC_823 0417-1665 178 µM -0.0200573853615091 0.467848574955132 no 1823 0.491998797427495 2469 3429856
SGTC_1240 0356-0016 42.1 µM -0.0204035179110163 0.467717962502541 no 1824 0.491860738774167 2461 4305613
SGTC_1741 st038134 10.228 µM -0.021943884906158 0.467136750318168 no 1825 0.491246359049722 2474 1272587
SGTC_289 k017-0060 526 µM -0.022887070721427 0.466780901394098 no 1826 0.4908701768826 2462 5512909
SGTC_2549 cedrol 20.94 µM -0.0242838594066566 0.466253964219697 no 1827 0.490313093831553 2458 6708665 A sedative which affects the nervous system.
SGTC_3109 9122853 49.47 µM -0.0243601982825461 0.46622516714927 no 1828 0.490282648032937 2497 1234709
SGTC_1886 st057356 49.9 µM -0.0245638701616634 0.466148337522205 no 1829 0.490201419016166 2459 24207747
SGTC_1474 0330-0125 5.35 µM -0.0250987790070986 0.465946563854411 no 1830 0.489988087043922 2455 X1474
SGTC_948 3448-0295 75.3 µM -0.0262601146051731 0.465508525129841 no 1831 0.489524933932764 2468 678569
SGTC_1766 st045414 44.774 µM -0.0266955514483543 0.46534429549321 no 1832 0.489351280649659 2455 253960
SGTC_2023 5144124 124 µM -0.0276763810815053 0.464974386829432 no 1833 0.488960130826381 2465 2830192
SGTC_2301 7769476 200 µM -0.0278923568028865 0.464892938114344 no 1834 0.488874002230562 2467 977820
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0282597992122414 0.464754371698011 no 1835 0.4887274716826 2489 521171
SGTC_3177 9107506 49.47 µM -0.0293656307882724 0.464337376777873 no 1836 0.488286491817062 2466 8897194
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0298694203545299 0.464147417145935 no 1837 0.488085596992357 2469 1273210
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.0324351597289933 0.463180103405547 no 1838 0.487062511910565 2502 6708739 YPR165W RHO1
SGTC_1930 st074634 34.3 µM -0.0387989444159734 0.460781833704157 no 1839 0.484525343218184 2478 684253 YOR116C RPO31
SGTC_2007 4011539 71.82 µM -0.0397444347554415 0.460425633709099 no 1840 0.48414843791622 2475 45595301
SGTC_1301 naphtanilide LB 4.81 µM -0.0425839261721605 0.459356087851598 no 1841 0.483016604461605 2496 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2446 5162541 200 µM -0.0433251797032976 0.459076929381509 no 1842 0.482721159781606 2484 1549321
SGTC_2091 4-phenylthiadiazole 200 µM -0.0452195285372072 0.45836360349912 no 1843 0.481966164324545 2505 270010
SGTC_301 4119-0100 24.5 µM -0.0454300832473292 0.458284326378629 no 1844 0.481882251385548 2492 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1074 carmofur 3.8 µM -0.0458663041053608 0.458120087730143 no 1845 0.481708405663623 2490 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_467 ro 31-8220 72.8 µM -0.0459901081208407 0.458073476395306 no 1846 0.481659067072263 2491 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1857 st056007 79.3 µM -0.0463314632576468 0.457944961592799 no 1847 0.481523031087424 2500 619834
SGTC_3049 9092223 49.47 µM -0.0463396565680316 0.457941876995186 no 1848 0.481519765936491 2556 8623917
SGTC_2755 lomerizine 42.69 µM -0.0468656855655064 0.457743844184664 no 1849 0.481310138490117 2507 3949 A calcium channel blocker.
SGTC_810 3825-7150 143 µM -0.0480837337384155 0.457285329010082 no 1850 0.480824754903101 2502 22330411 YGL099W LSG1
SGTC_2419 paclitaxel 166.5 µM -0.0482497819970926 0.45722282713129 no 1851 0.48075858803152 2462 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1917 st066507 28.5 µM -0.04968009172491 0.456684491200447 no 1852 0.480188660684169 2477 3156428
SGTC_1929 genistein trimethyl ether 50.5 µM -0.0509743522373288 0.456197429566686 no 1853 0.479672978960442 2497 136420
SGTC_1442 4112-3290 3 µM -0.0531586116337589 0.45537558938703 no 1854 0.478802766046528 2489 704353
SGTC_2455 5377712 9.75 µM -0.0532473280001791 0.455342213354395 no 1855 0.478767423392105 2558 2243908
SGTC_339 3091-4833 71.4 µM -0.053330051690044 0.455311092113854 no 1856 0.478734468238988 2516 3240077
SGTC_433 pimozide 108 µM -0.0533718158819584 0.455295380231953 no 1857 0.478717830432164 2486 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_162 k030-0015 37.8 µM -0.0555068728677237 0.454492255635052 no 1858 0.47786732731847 2533 1809920 YMR134W ERG29
SGTC_775 4577-0580 57.3 µM -0.0559793273029494 0.45431456184851 no 1859 0.477679137877573 2681 2006902
SGTC_1128 3448-9350 235 µM -0.0567519652176228 0.454023986439882 no 1860 0.477371389214111 2602 619386
SGTC_1125 tnp00248 1.32998 µM -0.057227031329586 0.453845334712014 no 1861 0.477182172776311 2547 24207736
SGTC_1382 3002-2117 298 µM -0.0579724249213481 0.453565043397013 no 1862 0.4768852966498 2500 1497314
SGTC_971 1315-0384 26.7 µM -0.0582600275470897 0.453456901986192 no 1863 0.476770753400923 2545 6769120
SGTC_404 fumagillin 50 µM -0.0600745201013244 0.452774714867182 no 1864 0.476048141657568 2533 12015870 A methionine aminopeptidase binder.
SGTC_3011 9081274 71.4286 µM -0.0606353358554768 0.452563895432008 no 1865 0.475824815672011 2551 6625322
SGTC_1980 st071811 45.7 µM -0.0608065932422278 0.452499519757608 no 1866 0.475756619696137 2652 4974850
SGTC_2376 9072922 81.32 µM -0.0608456689739373 0.452484831359768 no 1867 0.475741059546126 2632 17087968
SGTC_79 0052-0007 94.094 µM -0.0609905880987487 0.452430357458072 no 1868 0.475683352355674 2517 2801472
SGTC_1324 1418-0026 34.4 µM -0.0623225351530341 0.451929731628278 no 1869 0.475152991450143 2610 1372513
SGTC_2459 5811157 9.22 µM -0.0625705831667506 0.451836508680777 no 1870 0.475054227366874 2507 2870684 YBR192W RIM2
SGTC_1353 1498-1206 8.11 µM -0.0653348484645054 0.450797806166084 no 1871 0.473953698272165 2507 6756808
SGTC_462 ag-879 158 µM -0.0654820868952048 0.450742489123495 no 1872 0.473895084154555 2512 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2717 st081029 62.2815 µM -0.0654943300616013 0.450737889445191 no 1873 0.473890210300309 2512 5292846
SGTC_611 3453-1652 23.7 µM -0.0665179064362739 0.450353361888956 no 1874 0.473482751003361 2518 1560575
SGTC_1892 st058411 7.36 µM -0.0676118102775079 0.449942465891552 no 1875 0.473047326836523 2520 3934738
SGTC_933 2914-0560 114 µM -0.0690397110118916 0.44940619361091 no 1876 0.472479005038449 2530 463887
SGTC_2474 5321570 43.32 µM -0.0697050789897082 0.449156334908398 no 1877 0.472214199584176 2666 2841384
SGTC_926 2268-1401 59.4 µM -0.070366984140239 0.448907796568382 no 1878 0.471950784463268 2525 2931578
SGTC_881 0833-0569 170 µM -0.0717049494369125 0.448405466157226 no 1879 0.471418358611741 2538 5418700
SGTC_1765 st044815 90.4 µM -0.072903568132981 0.447955522739602 no 1880 0.470941427271142 2596 645695
SGTC_2785 7756463 72.73 µM -0.0732126234392403 0.447839518863435 no 1881 0.470818460647543 2545 2201551
SGTC_515 4092-1064 102 µM -0.0733659919302957 0.447781953672252 no 1882 0.470757439574237 2571 717353
SGTC_1042 0350-0096 82 µM -0.0746473892373842 0.447301038256472 no 1883 0.470247634058502 2519 3122515
SGTC_817 1391-0715 46 µM -0.0751776184194741 0.447102062965551 no 1884 0.47003669593316 2594 1353946
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.0753314198506842 0.447044349497718 no 1885 0.46997551153609 2523 2346 DNA damaging agent; causes G2/M arrest.
SGTC_3346 9158254 43.5805 µM -0.0761081627175245 0.446752896517044 no 1886 0.469666523034879 2609 17639500
SGTC_2739 tacrine 100.86 µM -0.0773154877439087 0.446299935692124 no 1887 0.469186285174464 2618 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2391 6285546 200 µM -0.0790157766287838 0.44566214501454 no 1888 0.468510037181724 2535 846083
SGTC_606 k015-0008 38.6 µM -0.0793910218302866 0.445521406701377 no 1889 0.468360804821669 2580 1970475
SGTC_3174 9107204 49.47 µM -0.083238927482 0.444078622270835 no 1890 0.466830780234825 2624 3938802
SGTC_355 1311-2252 105 µM -0.0841470043725801 0.443738243290529 no 1891 0.466469776525768 2584 5338538
SGTC_281 1672-3440 14.9 µM -0.0842083560075201 0.443715248045762 no 1892 0.466445387327364 2608 6833000
SGTC_849 0386-0493 241 µM -0.0863280450295812 0.442920882983409 no 1893 0.46560282249036 2562 726119
SGTC_364 0083-0097 67.7 µM -0.0865713430114596 0.442829720348182 no 1894 0.465506122660352 2667 5207356
SGTC_1698 5-fluorocytosine 1.055 µM -0.0865952817970707 0.442820750758745 no 1895 0.46549660819695 2564 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0870148284284011 0.442663556191349 no 1896 0.465329862716653 2547 4620898
SGTC_3096 9117468 49.47 µM -0.0872344889659226 0.442581257989108 no 1897 0.465242562804626 2556 41316311
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0895759053951188 0.441704175594658 no 1898 0.464312116063549 2548 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_656 4090-1979 187 µM -0.0905325106499579 0.441345918230799 no 1899 0.463932030128028 2575 22330961
SGTC_2394 5221648 200 µM -0.0928854994219758 0.440464907322786 no 1900 0.462997262862729 2658 788586
SGTC_85 0868-0259 160.055 µM -0.0930986179793086 0.440385125519734 no 1901 0.462912607680898 2640 83173
SGTC_1390 3413-2614 145 µM -0.0932553055875621 0.440326470416699 no 1902 0.462850369132342 2596 3421432
SGTC_2222 6885208 172.143 µM -0.0938294032964912 0.440111571446256 no 1903 0.462622337131518 2591 609514
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.0948684103010903 0.439722690326158 no 1904 0.462209674124247 2587 689007
SGTC_373 0844-0104 25.9 µM -0.0952637642866414 0.439574731889294 no 1905 0.462052661814328 2619 5375804
SGTC_649 1123-0311 367 µM -0.0954717992440402 0.439496879663496 no 1906 0.461970044432834 2638 693629 YIL048W NEO1
SGTC_2487 5918373 44.05 µM -0.0959676227014679 0.439311338750284 no 1907 0.461773143592024 2559 2876279
SGTC_3179 9107801 49.47 µM -0.096128592546365 0.439251105473328 no 1908 0.461709221444695 2600 4818259
SGTC_919 tnp00227 403.569 nM -0.0985920282279236 0.438329489208197 no 1909 0.46073109986747 2629 1269246 A methoxyflavone. YNL221C POP1
SGTC_1228 0124-0032 52.5 µM -0.0987385780994476 0.438274672713221 no 1910 0.460672918809614 2636 X1228
SGTC_1834 st055981 52.8 µM -0.0992335080141422 0.438089554574027 no 1911 0.46047643530056 2738 471719 YDL150W RPC53
SGTC_357 1325-0123 420 µM -0.0996002231546929 0.437952401213168 no 1912 0.460330858328031 2583 1098503
SGTC_2594 a-mangostin 100 µM -0.0996334335808737 0.43793998070968 no 1913 0.460317674860581 2694 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1198 1612-1005 86.7 µM -0.1018719162219 0.437102942966551 no 1914 0.459429170787063 2741 6998509
SGTC_2104 5389443 200 µM -0.102895906627842 0.436720134953571 no 1915 0.459022793247765 2704 2244536
SGTC_419 nsc-638432 893 µM -0.10309222023153 0.436646751940867 no 1916 0.458944889740382 2649 368090
SGTC_891 0929-0073 133 µM -0.106378377390638 0.435418695487203 no 1917 0.457641074031833 2747 5603632
SGTC_508 roscovitine 141 µM -0.106571714339494 0.435346463597247 no 1918 0.457564379722389 2595 160355 A CDKinase inhibitor.
SGTC_749 1000-0129 128 µM -0.109166348448996 0.434377301791317 no 1919 0.456535275400017 2706 708470
SGTC_2324 6149169 200 µM -0.109877442041537 0.434111758842011 no 1920 0.456253286423607 2669 2888231
SGTC_2200 6600604 21.907 µM -0.110697465881228 0.433805575098462 no 1921 0.455928127782247 2602 2904777
SGTC_3123 9126162 49.47 µM -0.111935934664302 0.43334322606946 no 1922 0.455437101947511 2616 25239884
SGTC_1820 st053765 18.6 µM -0.11241994939165 0.43316255693583 no 1923 0.455245219132641 2679 3690829
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.113617231914859 0.432715705011435 no 1924 0.454770613358294 2595 15053
SGTC_653 0203-0016 55.2 µM -0.113896183820906 0.432611606418539 no 1925 0.454660045375962 2685 295302
SGTC_634 1611-4317 11.2 µM -0.114417227624836 0.432417177093253 no 1926 0.454453529003712 2596 2843522
SGTC_800 3448-7362 155 µM -0.115085309330783 0.432167904007184 no 1927 0.454188751993201 2601 15991913
SGTC_2216 7189485 200 µM -0.11514150770974 0.432146936629045 no 1928 0.454166480136935 2642 731273
SGTC_2386 9075165 157.42 µM -0.11584395863446 0.431884871294516 no 1929 0.453888105533357 2598 16452277
SGTC_2618 avocadyne 43.43 µM -0.11653311991289 0.431627793091436 no 1930 0.453615019502015 2644 3015189
SGTC_2035 5154463 94.595 µM -0.119301362089997 0.430595447048833 no 1931 0.452518302208074 2695 2769623
SGTC_2851 9015922 71.43 µM -0.119656147417486 0.430463172946003 no 1932 0.452377769990302 2731 2996893
SGTC_2102 5377816 72.7585 µM -0.120248923612653 0.430242186465437 no 1933 0.452142981735738 2744 1379702
SGTC_2279 7948423 32.93 µM -0.121249224571872 0.429869324661509 no 1934 0.4517468180597 2602 1247112
SGTC_1421 4029-0249 71.4 µM -0.122020560003274 0.429581852358925 no 1935 0.451441367705714 2724 2894095
SGTC_2836 9010338 19.48 µM -0.122544021426295 0.429386782537865 no 1936 0.45123409231203 2642 2994051
SGTC_1429 4049-0205 9.46 µM -0.124014889329815 0.428838750651208 no 1937 0.450651743045488 2605 22774478
SGTC_1725 st036284 20.55 µM -0.124019170802524 0.428837155613464 no 1938 0.450650048069802 2859 707914
SGTC_993 3909-8757 62.7 µM -0.124273773619389 0.428742306905938 no 1939 0.450549255963628 2675 4288324 YLR208W SEC13
SGTC_1248 0469-0687 58.6 µM -0.12479951801201 0.428546461236778 no 1940 0.450341134490134 2717 4017482
SGTC_503 tyrphostin 8 294 µM -0.1254821295699 0.428292207052443 no 1941 0.450070935874161 2622 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1085 doxorubicin 7.67 µM -0.12568503481244 0.428216636118458 no 1942 0.449990624204868 2667 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1065 prochlorperazine maleate 2.48 µM -0.125904305168327 0.428134973048263 no 1943 0.449903837383244 2636 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2735 sertaconazole 140 nM -0.12600722451059 0.428096643759433 no 1944 0.449863102914348 2616 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2357 9067248 200 µM -0.126444538609217 0.427933786526268 no 1945 0.449690024168294 2707 9150235
SGTC_2801 7907800 81.82 µM -0.127581142807615 0.427510568801933 no 1946 0.449240227512034 2703 6620925
SGTC_1914 st062367 72.6 µM -0.127712833716742 0.427461538708954 no 1947 0.449188116714766 2666 978205
SGTC_3031 9088762 49.47 µM -0.127715829349003 0.427460423412435 no 1948 0.449186931337245 2615 205253
SGTC_1163 k060-0048 49.9 µM -0.128357162413544 0.427221663629694 no 1949 0.448933165053361 2634 6809982
SGTC_2362 9071156 126 µM -0.128612783956513 0.427126506548833 no 1950 0.448832025096126 2777 653133
SGTC_2821 7996764 71.43 µM -0.128614453216326 0.427125885167987 no 1951 0.448831364642893 2761 2987135
SGTC_65 0798-0905 34.986 µM -0.132520534390591 0.425672347536096 no 1952 0.447286291082893 2999 3602145
SGTC_1646 st011709 75.6 µM -0.133325420735118 0.425372956637151 no 1953 0.446968012113063 2655 5757843
SGTC_2817 7995342 71.43 µM -0.133997435896197 0.425123022342198 no 1954 0.446702301004382 2646 18879975
SGTC_2057 5236571 38.335 µM -0.139927656235116 0.422918784258181 no 1955 0.444358574869054 2734 54684039 YBR257W POP4
SGTC_963 1269-2853 151 µM -0.139976756735619 0.422900543776787 no 1956 0.444339177501089 2686 3668223
SGTC_2963 9082507 9 µM -0.140328324776607 0.422769943619203 no 1957 0.444200292902802 2781 16459611
SGTC_2034 5197015 53.07 µM -0.141426834328571 0.422361925107314 no 1958 0.443766378294989 2796 780676
SGTC_958 1222-0007 33 µM -0.142111512820456 0.42210765764104 no 1959 0.443495962279435 2794 7312461
SGTC_559 1550-0661 158 µM -0.1431883106546 0.421707835434495 no 1960 0.443070730719135 2731 5830875
SGTC_2351 9026858 72.31 µM -0.144425750418245 0.421248465482072 no 1961 0.442582142038943 2662 1409300
SGTC_2453 5731132 22.18 µM -0.144569067886997 0.421195269208844 no 1962 0.442525560433167 2774 1362040
SGTC_1667 st014849 34.6 µM -0.149843620028802 0.419238480712767 no 1963 0.440443997019433 2640 5348460
SGTC_2523 spermine 47.74 µM -0.149996953488881 0.419181625665014 no 1964 0.4403835094157 2748 1103 A DNA binding polyamine.
SGTC_2988 9073640 71.4286 µM -0.150280562473203 0.419076469749995 no 1965 0.440271633863337 2837 9102229
SGTC_2114 5491910 81.25 µM -0.150608543108918 0.418954869020085 no 1966 0.440142260922214 2777 2849228
SGTC_3091 9116372 49.47 µM -0.15097743596615 0.418818109097419 no 1967 0.439996757669689 2838 17169793
SGTC_929 2805-0021 398 µM -0.15302163741758 0.418060439021315 no 1968 0.439190606023824 2780 3098024
SGTC_3335 9143315 29.6265 µM -0.154140094302499 0.417646018677527 no 1969 0.438749637672275 2741 4899691
SGTC_2286 7945697 125 µM -0.154986335301128 0.417332522869049 no 1970 0.43841604499108 2755 1245733
SGTC_2337 9009472 200 µM -0.155388140010104 0.417183689930925 no 1971 0.438257666751607 2790 5742383
SGTC_3343 9148379 18.9835 µM -0.15675735973251 0.416676604939022 no 1972 0.437718039649245 2815 1955036
SGTC_181 1447-1644 8.07 µM -0.1570046503355 0.41658503661727 no 1973 0.437620591560331 2726 534600
SGTC_731 3966-0296 387 µM -0.157352408716885 0.41645627411294 no 1974 0.437483559235033 2687 660956
SGTC_3072 9116419 49.47 µM -0.157787981127038 0.416295009858258 no 1975 0.437311934842016 2767 17170162
SGTC_1919 st067113 52.3 µM -0.1608306833484 0.415168888721851 no 1976 0.436113378998442 2822 1268243
SGTC_2048 5246248 200 µM -0.161428621322257 0.414947670131304 no 1977 0.43587791286507 2733 677046
SGTC_130 0136-0219 337.655 µM -0.162062145713773 0.414713315086924 no 1978 0.435628457708021 2671 234244
SGTC_3265 9137266 49.47 µM -0.162320269216747 0.414617838045408 no 1979 0.435526826908481 2649 17224265
SGTC_705 1124-0212 310 µM -0.162431311318439 0.414576766346059 no 1980 0.435483107683268 2712 9554485
SGTC_2670 beta-carotene 100 µM -0.164035099467793 0.41398366954435 no 1981 0.434851756330811 2719 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_378 3970-0959 8.33 µM -0.165228329387954 0.4135425284255 no 1982 0.434382134039424 2818 6615653
SGTC_1663 st014140 55.4 µM -0.167971519979916 0.412528776238664 no 1983 0.433302842237512 2711 4207120
SGTC_1839 st053978 48 µM -0.168820388059485 0.412215192997113 no 1984 0.432968960573816 2703 3788398
SGTC_1984 st072354 53.1 µM -0.168887568087106 0.41219037818515 no 1985 0.432942538979852 2703 5762938
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.169170742993841 0.412085783516004 no 1986 0.432831170895827 2704 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3165 9101544 49.47 µM -0.169353159654612 0.412018408641058 no 1987 0.432759432215495 2814 5002184
SGTC_2080 5212524 12.4 µM -0.17040435906144 0.411630202872433 no 1988 0.432346072122443 2706 260183
SGTC_2697 mebhydrolin 72.4 µM -0.170705074403558 0.411519165211119 no 1989 0.432227836300938 2823 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2019 4016004 108 µM -0.17198245990295 0.411047575982261 no 1990 0.431725659250847 2785 45595336
SGTC_3230 9131665 49.47 µM -0.172398087574643 0.410894160920435 no 1991 0.431562287782616 2704 15943720
SGTC_1567 st069303 68.4 µM -0.17306779180689 0.410646990671611 no 1992 0.431299070651555 2822 5581319
SGTC_1283 0922-0125 16.4 µM -0.174325267007771 0.410182985517972 no 1993 0.43080492152782 2826 3360884
SGTC_1870 st057514 26.5 µM -0.175021110783588 0.40992627492334 no 1994 0.430531522802792 2680 5393161
SGTC_2055 5235184 200 µM -0.175258524867858 0.409838696977111 no 1995 0.430438249838487 2869 2836034
SGTC_2957 9076800 11.52 µM -0.175769197163047 0.409650334054563 no 1996 0.430237634972169 2781 16459615
SGTC_1945 st075991 56.6 µM -0.176478694854974 0.409388668440359 no 1997 0.429958942515557 2770 1084980
SGTC_1793 st048256 72.231 µM -0.176592651285307 0.409346644607705 no 1998 0.429914183395253 2686 672022
SGTC_3195 9113082 49.47 µM -0.177305488091213 0.409083794686357 no 1999 0.429634220110091 2715 17018038
SGTC_1092 toremifene 6.32 µM -0.177336215315019 0.409072465313608 no 2000 0.429622152932693 2700 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2234 tolnaftate 200 µM -0.178342709614582 0.408701404876364 no 2001 0.429226919495666 2755 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_270 tamoxifen 5.46 µM -0.178509103592788 0.40864006891206 no 2002 0.429161586192902 2893 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1519 esterone 74 µM -0.179005162041939 0.408457225679856 no 2003 0.428966824219953 2707 698 A steroid.
SGTC_561 1550-0330 72.9 µM -0.179606650803728 0.408235548398005 no 2004 0.428730691504692 2743 6812934
SGTC_1012 4112-3522 18 µM -0.179873563692108 0.408137187677217 no 2005 0.428625914895184 2832 3112398
SGTC_518 1021-0119 62.6 µM -0.180187274298135 0.408021588815164 no 2006 0.428502774280523 2776 1097762
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.180661858714458 0.407846724966485 no 2007 0.428316499210252 2864 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_521 r062-0005 13.8 µM -0.181930584815423 0.407379344442253 no 2008 0.427818600905995 2693 2832033
SGTC_2173 5763948 167 µM -0.182141460864252 0.407301673484796 no 2009 0.42773585591979 2716 2867177
SGTC_3262 9137218 49.47 µM -0.183700966601448 0.406727381598627 no 2010 0.427124025288138 2675 17650664
SGTC_1081 sertraline 6 µM -0.184510069298711 0.406429506436463 no 2011 0.426806664305643 2839 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2727 riluzole 51.77 µM -0.1852669298103 0.406150913499767 no 2012 0.426509837584863 2724 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1708 st033234 31.827 µM -0.185363876430069 0.40611523182886 no 2013 0.426471819913691 2851 674664
SGTC_783 0848-0141 92.7 µM -0.185636903321263 0.406014747156315 no 2014 0.42636475593801 2717 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_560 2332-1943 155 µM -0.18591922924878 0.40591084658247 no 2015 0.426254051171852 2724 21177716
SGTC_1773 st048542 73.5835 µM -0.18686371762051 0.405563307572995 no 2016 0.425883743607428 2721 3237138
SGTC_102 gallobenzophenone 83.616 µM -0.186929932945044 0.405538945415784 no 2017 0.425857784871968 2897 70837
SGTC_2879 9041815 71.43 µM -0.188152008540094 0.405089381187045 no 2018 0.425378746070892 2737 4942971
SGTC_2681 menadione 3.18 µM -0.189207147590674 0.404701328509614 no 2019 0.424965232940103 2802 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2488 5268135 45.7 µM -0.190375182681455 0.40427186490501 no 2020 0.424507571693034 2870 1270356 YLR208W SEC13
SGTC_3204 9114183 49.47 µM -0.191062448766668 0.404019224500247 no 2021 0.424238333585433 2707 17027248
SGTC_2180 6301957 200 µM -0.191615849376287 0.403815822403712 no 2022 0.424021563280903 2799 845462
SGTC_2887 9044784 58.44 µM -0.192243207358554 0.403585268769849 no 2023 0.423775851235938 2755 6465546
SGTC_1267 0828-0272 9.49 µM -0.194477205724832 0.402764548452667 no 2024 0.422901121093441 2885 745334
SGTC_2838 9002687 71.43 µM -0.196367979646482 0.402070255485015 no 2025 0.422161078431911 2727 6457060
SGTC_1007 4101-0031 70 µM -0.196402214505852 0.402057687271004 no 2026 0.422147681545557 2925 1146276
SGTC_633 0437-0093 97.7 µM -0.197397462027357 0.401692358863208 no 2027 0.421758257778743 2741 2831118
SGTC_2219 9098279 200 µM -0.197734212826182 0.401568766199191 no 2028 0.421626510106452 2765 902349
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.198829385616011 0.40116688926869 no 2029 0.421198104248902 2751 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1183 1254-0324 198 µM -0.199125490838799 0.401058250507958 no 2030 0.421082290842976 2884 5799357
SGTC_3212 9128307 49.47 µM -0.199558935016764 0.400899236923554 no 2031 0.42091277340207 2751 27243542
SGTC_1711 st032263 62.8 µM -0.199615952752129 0.400878320585164 no 2032 0.420890475195352 2810 3958979
SGTC_3170 9103054 49.47 µM -0.200152805019365 0.400681396088941 no 2033 0.420680538187755 2818 16432970
SGTC_3251 9135047 49.47 µM -0.201674750692924 0.400123263684182 no 2034 0.420085501511279 2855 17682963
SGTC_2981 9013952 38.96 µM -0.201935894057776 0.400027516886711 no 2035 0.419983420337603 2821 2996344
SGTC_1465 k213-0056 144 µM -0.204083626264391 0.399240290982426 no 2036 0.419144074706231 2760 24048857 YMR208W ERG12
SGTC_1868 st057644 42.7 µM -0.204576019336194 0.399059867708248 no 2037 0.418951696464558 2753 688665
SGTC_1317 1273-0028 910 nM -0.207871879238974 0.397852751675957 no 2038 0.417664503333006 2806 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2728 chlorpromazine 9.18 µM -0.210953225120886 0.396725085443981 no 2039 0.416461885442286 2745 2726 A thorazine and dopamine antagonist.
SGTC_600 1495-0418 41.6 µM -0.211458968871357 0.396540082899714 no 2040 0.416264573178743 2786 5377768
SGTC_2774 tamoxifen 10.92 µM -0.211567238280689 0.396500480658044 no 2041 0.416222335392811 2766 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3234 9132280 49.47 µM -0.211649810244422 0.396470278616823 no 2042 0.416190123279115 2852 17612295
SGTC_1827 berberine 7.24 µM -0.211760681272437 0.396429726708785 no 2043 0.416146872314916 2777 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2227 7312221 64.1025 µM -0.212201240739763 0.396268599862686 no 2044 0.415975019405861 2792 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_314 1671-0008 2.74 µM -0.21233914147211 0.396218168744249 no 2045 0.415921230553284 2771 3913060
SGTC_1197 1601-0112 267 µM -0.214797229398979 0.395319523488948 no 2046 0.414962706551839 2779 7350313
SGTC_2002 4023503 131 µM -0.214994346177726 0.39524748417092 no 2047 0.414885863296353 2834 4736863 YCR052W RSC6
SGTC_899 1083-0020 478 µM -0.216786816064314 0.394592563429891 no 2048 0.414187243450283 2968 767123
SGTC_2598 perillyl alcohol 100 µM -0.217049980190554 0.394496435296677 no 2049 0.414084697339368 2945 10819 An apoptosis inducer.
SGTC_3046 9092212 49.47 µM -0.218320684060051 0.394032365304851 no 2050 0.413589629795921 2772 25236637
SGTC_1561 5-methoxyflavone 52.9 µM -0.220618459963462 0.393193583709435 no 2051 0.412694763115785 2794 94525
SGTC_1137 ixabepilone 100 µM -0.224658493058279 0.391720011221321 no 2052 0.411122478456565 2784 154225 A novel microtubule stabilizer.
SGTC_430 0958-0115 16.4 µM -0.225078349749897 0.391566960243442 no 2053 0.410959161635964 2831 6833180
SGTC_490 phenamil 164 µM -0.226265907825857 0.391134148894293 no 2054 0.410497306216623 2902 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_940 3232-1287 54.8 µM -0.2268234983797 0.39093097875603 no 2055 0.410280495408386 2795 1585493 YIL048W NEO1
SGTC_3061 glucosamine 200 µM -0.226965602811455 0.390879204700409 no 2056 0.410225244591826 2842 91431 and experimental redox chemotherapeutic
SGTC_2950 9072895 21.46 µM -0.227324819455473 0.390748337024622 no 2057 0.410085587557822 2926 17332245
SGTC_2948 9070189 9.45 µM -0.227409841502802 0.390717364107276 no 2058 0.410052534168307 2969 6473636 YDL196W YDL196W
SGTC_1323 1348-1351 11.2 µM -0.227426119648968 0.390711434175352 no 2059 0.410046205907274 2828 6989654
SGTC_1832 st054113 55 µM -0.227443202618555 0.390705211083315 no 2060 0.410039564789818 2893 1251267
SGTC_1335 1486-0900 202 µM -0.227533879113818 0.390672179345698 no 2061 0.410004314134356 2781 X1335
SGTC_2829 7992743 58.44 µM -0.227786746090649 0.390580068841973 no 2062 0.409906015471687 3014 16462845
SGTC_1489 4065-0444 182 µM -0.227852774814092 0.390556017922174 no 2063 0.409880348618606 2901 2877968
SGTC_941 3237-0776 460 µM -0.228397937814962 0.390357458661391 no 2064 0.409668446237939 2988 760008
SGTC_2195 6536160 144.242 µM -0.228804203862116 0.390209507039252 no 2065 0.40951054962521 2804 3834386
SGTC_3227 9130768 49.47 µM -0.229436930419898 0.389979116009577 no 2066 0.409264667640361 2815 17720899
SGTC_724 3910-0327 137 µM -0.229599986378256 0.389919749654324 no 2067 0.409201308730045 2869 2885483
SGTC_2709 st078560 56 µM -0.230544285637135 0.389575994260083 no 2068 0.408834427575821 2958 17250903
SGTC_1988 st071872 53.4 µM -0.232110603847969 0.38900599447426 no 2069 0.408226054544387 2936 16414116
SGTC_2308 7584454 197.62 µM -0.233065285020246 0.388658692940485 no 2070 0.407855355590319 2971 893577
SGTC_1662 st014054 52 µM -0.233322118499946 0.388565275185142 no 2071 0.40775564222245 2816 2838777
SGTC_442 cape 100 µM -0.233490533634813 0.388504021234051 no 2072 0.407690259752338 2954 5281787
SGTC_2294 7971431 200 µM -0.233960468427047 0.388333116803279 no 2073 0.407507834301989 2955 5741572
SGTC_1462 k081-0014 26.5 µM -0.234279855111325 0.388216975579772 no 2074 0.407383862035553 2842 3270634
SGTC_2243 6634756 200 µM -0.23434625039026 0.388192832969566 no 2075 0.407358091388919 3094 885676
SGTC_537 1334-0398 209 µM -0.235799372970727 0.387664557793591 no 2076 0.406794177368394 2984 5846986
SGTC_2747 doxorubicin 7.63 µM -0.236289955144247 0.387486256079421 no 2077 0.406603840458719 2819 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2040 5100729 123 µM -0.236385625956893 0.387451487359837 no 2078 0.406566724502841 2829 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_737 1950-0117 57.9 µM -0.23827803618687 0.386763932842762 no 2079 0.405832727697267 2942 5393513
SGTC_1432 4049-0298 68.4 µM -0.238364263516681 0.386732612991658 no 2080 0.405799291128983 2932 741646
SGTC_2904 7225135 42.03 µM -0.239192785650251 0.386431711345043 no 2081 0.405478048272393 2922 4446116
SGTC_2074 5212007 75.395 µM -0.241120340742013 0.385731928756637 no 2082 0.404730924084255 2884 758611
SGTC_2643 anethole 100 µM -0.241318056721948 0.385660170623233 no 2083 0.404654308564004 2881 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3104 9120930 49.47 µM -0.242800088569875 0.385122413519723 no 2084 0.40408013347738 2916 17014836
SGTC_2897 9048598 12.99 µM -0.242867887381901 0.385097817911259 no 2085 0.404053871505234 2843 6467404
SGTC_2742 clothiapine 36.27 µM -0.243009270143872 0.385046529487112 no 2086 0.403999108070282 2879 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3292 9120825 59.784 µM -0.243292349258735 0.384943844924742 no 2087 0.403889465389499 2953 24824900
SGTC_795 0685-0265 78 µM -0.243754205013419 0.384776327968004 no 2088 0.403710594852314 2831 302754
SGTC_1427 4048-4900 550 nM -0.244929591305117 0.384350107674814 no 2089 0.403255474423559 2957 24132586
SGTC_2570 licareol 100 µM -0.246348368680467 0.383835814793587 no 2090 0.402706285277682 2927 443158
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.246640172675649 0.383730064037459 no 2091 0.40259335573838 2830 688803
SGTC_1225 1216-0074 20.6 µM -0.247159998560698 0.383541698832633 no 2092 0.402392200779821 2868 4241466
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.247235288223605 0.383514418992107 no 2093 0.402363068379272 3045 94937 An inhibitor of serotonin biosynthesis.
SGTC_1694 st024011 44.9 µM -0.24801794886666 0.383230870361924 no 2094 0.402060259705093 2862 2787533
SGTC_1134 3477-0009 42.5 µM -0.248572117445801 0.383030139496037 no 2095 0.401845889344105 3117 3973534
SGTC_3105 9121040 49.47 µM -0.252703485487863 0.381534669162819 no 2096 0.400248677129468 2775 41448907
SGTC_3051 9093778 49.47 µM -0.252808437445059 0.381496701628952 no 2097 0.400208123658536 2846 17217378
SGTC_1354 1498-1681 81 µM -0.254281913393811 0.380963775912148 no 2098 0.399638885852464 2938 5754243
SGTC_2442 5158906 48.48 µM -0.254864516767963 0.380753122556086 no 2099 0.399413871468542 2991 1893835
SGTC_1251 0490-5699 265 µM -0.255137074890377 0.380654585167265 no 2100 0.399308614924628 3019 3883818
SGTC_602 3130-1533 38.1 µM -0.259270511260476 0.379161184636216 no 2101 0.39771326513139 2985 720941
SGTC_189 3970-0742 2.116 µM -0.260372602389866 0.378763305091053 no 2102 0.39728818721715 2890 2891807
SGTC_836 0330-0104 1.35 µM -0.261410041330135 0.378388883791916 no 2103 0.396888157162179 2878 46494820
SGTC_374 0880-0231 82.3 µM -0.26145999615272 0.378370857512829 no 2104 0.396868897624904 2949 6833587
SGTC_1556 plumbagin 1.48 µM -0.26358353524479 0.377604820231593 no 2105 0.396050423476692 2852 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_406 estrone 100 µM -0.264329984211752 0.377335663260977 no 2106 0.395762828801439 3056 5870 A steroid.
SGTC_2193 5925765 200 µM -0.264395173101896 0.377312160067855 no 2107 0.395737715271608 2991 877370
SGTC_3324 9138759 60.749 µM -0.266382041445824 0.376596033216223 no 2108 0.394972497288024 3003 45595710
SGTC_698 k064-0052 127 µM -0.266688831670916 0.376485494601958 no 2109 0.394854376810234 2858 5088751
SGTC_1450 4112-4260 37.6 µM -0.268059260056724 0.375991843676041 no 2110 0.394326852149612 3029 1633175
SGTC_1229 0139-0193 12.2 µM -0.268948139088599 0.375671763180486 no 2111 0.393984795805613 3019 3090752
SGTC_1842 st055362 61.2 µM -0.269991237478516 0.375296258239844 no 2112 0.393583497420782 2891 676032
SGTC_410 α-linolenic acid 100 µM -0.271307561081487 0.374822563603834 no 2113 0.393077245794009 2996 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1518 st038567 90.8 µM -0.273182121166655 0.374148306971023 no 2114 0.392356611351539 2879 77966
SGTC_3187 9109394 49.47 µM -0.273322815943723 0.37409771625762 no 2115 0.392302539115739 2935 17098090
SGTC_155 k072-0202 43.6 µM -0.275208756677727 0.373419783561632 no 2116 0.391577929892221 2835 5857737
SGTC_2117 5521686 200 µM -0.275544880832667 0.373298999210781 no 2117 0.39144882491288 2852 803312
SGTC_1158 4092-0494 91.8 µM -0.27562096886037 0.373271659127548 no 2118 0.391419601230481 3022 1148199
SGTC_1751 st044839 27.194 µM -0.275798345170022 0.373207926439193 no 2119 0.39135147740058 2876 5291326
SGTC_74 000s-0487 160.283 µM -0.277336351783999 0.372655454310966 no 2120 0.390760924583044 2856 677548
SGTC_1563 conessine 56.1 µM -0.277764796008239 0.372501598120567 no 2121 0.390596458418295 3014 441082 An anti-amoebic, histamine inhibitor.
SGTC_8 0354-0001 70 µM -0.277984123805253 0.372422844422961 no 2122 0.390512272997381 2918 4993152
SGTC_312 4092-0653 6.84 µM -0.278919466307573 0.372087052335084 no 2123 0.390153314596447 2997 1148278
SGTC_2939 9044578 71.43 µM -0.279785091920822 0.371776375559709 no 2124 0.389821195015411 2877 2653634
SGTC_1655 st012546 55.1 µM -0.279911697225832 0.371730943361575 no 2125 0.389772626362705 3006 720985 YLR208W SEC13
SGTC_285 1486-1325 46 µM -0.280048052221761 0.37168201449377 no 2126 0.389720319433595 3022 22310230
SGTC_1488 4013-0813 75.9 µM -0.280399079774667 0.37155606325893 no 2127 0.389585671488604 2904 2910057
SGTC_1117 retinoic acid 1.10837 µM -0.280400579375668 0.371555525220688 no 2128 0.389585096296668 3061 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_424 splitomicin 100 mM -0.281647052587809 0.371108392973765 no 2129 0.389107078660831 2979 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2449 5812982 45.77 µM -0.282410610899732 0.370834576813883 no 2130 0.388814339841553 2966 776185
SGTC_123 0083-0120 66.675 µM -0.283053216135633 0.370604185756125 no 2131 0.38856802184301 2917 16001701
SGTC_2680 butyl paraben 22.24 µM -0.283086099978803 0.370592397271442 no 2132 0.388555418290756 2895 7184 An antifungal and steroid mimetic.
SGTC_137 0438-0332 85.389 µM -0.284097051569617 0.370230041930706 no 2133 0.388168003212415 2962 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1825 st052143 62.6 µM -0.284478739506378 0.370093263461855 no 2134 0.388021762348864 3074 674173
SGTC_182 3448-4371 550.524 µM -0.285201861873453 0.369834176487127 no 2135 0.387744747002904 2906 3491403
SGTC_680 0417-1641 114 µM -0.285614999474552 0.369686180231965 no 2136 0.387586506952539 2882 2835990
SGTC_2848 9016370 25.97 µM -0.286259290364426 0.369455417598713 no 2137 0.387339767793595 3011 7894410
SGTC_1407 3909-7909 12.3 µM -0.28671613818816 0.369291819051825 no 2138 0.387164839839303 2927 4411780
SGTC_3069 9117009 49.47 µM -0.288593949210521 0.368619618290114 no 2139 0.386446063205192 2973 41904981
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.288680544403886 0.368588629450688 no 2140 0.38641292621965 2942 368090
SGTC_999 SEC7.066 22.7 µM -0.289754236540342 0.368204470473627 no 2141 0.386002130254556 2916 740511 YDR170C SEC7
SGTC_952 1185-0122 232 µM -0.289926577027154 0.368142820602911 no 2142 0.385936204457041 2866 678600
SGTC_908 3448-7491 47.7 µM -0.290955023549105 0.36777499397028 no 2143 0.385542859016722 2905 1203031
SGTC_3130 9127414 49.47 µM -0.291207484793467 0.367684719055131 no 2144 0.385446319245027 2922 1494646
SGTC_190 3970-0790 3.722 µM -0.291867792503196 0.367448641259131 no 2145 0.385193854830547 2998 2832352
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.293808236415203 0.36675517045265 no 2146 0.384452220490515 3092 5393153
SGTC_3162 9099653 49.47 µM -0.295194407403244 0.36626005027539 no 2147 0.383922686996214 3040 25237511
SGTC_3266 9136860 49.47 µM -0.296436989874129 0.365816406973819 no 2148 0.383448190100864 3034 4871271 YPR165W RHO1
SGTC_2638 epoxomicin 18 µM -0.297704612449642 0.365364008357379 no 2149 0.382964311373217 3032 9915668 A protesome inhibitor.
SGTC_236 1509-0011 5.31 µM -0.297968311447922 0.365269920997885 no 2150 0.3828636747258 3048 3107280
SGTC_443 clozapine 122 µM -0.298259134297264 0.365166165296654 no 2151 0.382752695848972 2955 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_73 0327-0325 16.231 µM -0.300045985955718 0.364528894266964 no 2152 0.382071039448839 3050 53298
SGTC_322 k048-0136 19.3 µM -0.300265247702891 0.364450721487165 no 2153 0.381987419595123 3013 6823282
SGTC_2650 prasterone 100 µM -0.303261772241948 0.363382945158965 no 2154 0.380845188273707 2951 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2653 dihydrofissinolide 100 µM -0.303270516193419 0.363379830902607 no 2155 0.380841856720944 3008 6857746
SGTC_1995 st072814 61.1 µM -0.304108781804386 0.36308131516224 no 2156 0.380522508296226 2943 5769371
SGTC_747 3448-8087 38.7 µM -0.304751286210191 0.3628525684582 no 2157 0.380277792798403 2992 5168703
SGTC_1602 st001878 87.6 µM -0.305019178048477 0.36275720710172 no 2158 0.380175772961659 3118 595405 YLR310C CDC25
SGTC_149 3970-0822 46.1 µM -0.30598569469998 0.362413227321077 no 2159 0.379807768858 2966 3114250 YBL034C STU1
SGTC_3014 9081533 49.47 µM -0.307197091187953 0.361982252528876 no 2160 0.379346679727628 3094 21367265
SGTC_2784 7567673 72.73 µM -0.307359601838829 0.361924449913 no 2161 0.379284836968645 2911 3471247
SGTC_1453 4237-0541 195 µM -0.307407726485685 0.361907333297905 no 2162 0.379266523925195 3071 739892
SGTC_1435 4092-0789 56.7 µM -0.308060418597198 0.361675215931109 no 2163 0.379018179438726 3049 2248285
SGTC_683 panaxydol 45 µM -0.308612937128976 0.361478763134729 no 2164 0.378807989272094 2970 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2103 5378138 10 µM -0.309060427901979 0.361319680635699 no 2165 0.378637780231956 2965 244142
SGTC_2541 muurolladie-3-one 83.07 µM -0.313133589910897 0.359872781253923 no 2166 0.377089585176365 3118 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2409 alverine citrate 63.97 µM -0.313263206693005 0.359826770622759 no 2167 0.37704035055241 3180 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3146 9095609 49.47 µM -0.31652001607606 0.358671355192363 no 2168 0.375803917449583 3010 17173999
SGTC_1643 st009866 20.2 µM -0.316916398605647 0.358530818908844 no 2169 0.37565351931953 3057 3156273 YOR207C RET1
SGTC_330 1488-0319 80.1 µM -0.317762009835473 0.358231073928267 no 2170 0.375332734976269 3031 6846614
SGTC_438 sphingosine 6.67 µM -0.318805437188497 0.357861329197665 no 2171 0.374937027490015 2956 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_664 1222-0054 14.9 µM -0.318924238893969 0.357819239549131 no 2172 0.374891981686119 2982 6813991
SGTC_2624 nerol 100 µM -0.318994142312404 0.357794474632347 no 2173 0.374865477344967 2934 637566 A natural product oil.
SGTC_842 0271-0008 11.1 µM -0.321051673014126 0.357065814875897 no 2174 0.374085616240952 3099 1221709
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.322040366321477 0.356715861395708 no 2175 0.373711057108098 3213 6728940
SGTC_2005 4024620 188 µM -0.322256035627416 0.356639540057214 no 2176 0.373629368220585 2955 236743
SGTC_3344 9148862 3.898 µM -0.322484710959391 0.356558622398255 no 2177 0.373542759252366 3143 4905352
SGTC_3241 9133421 49.47 µM -0.32520606863621 0.355596155845081 no 2178 0.372512557999794 3026 17018221
SGTC_2695 st077686 51.995 µM -0.326557260102927 0.35511861937771 no 2179 0.372001387077919 3032 2876092
SGTC_2816 7982706 58.44 µM -0.326950570286688 0.354979658872555 no 2180 0.371852635749832 3077 2981853
SGTC_2240 6690706 185.951 µM -0.327879115174036 0.354651671029409 no 2181 0.371501532647677 2888 805876
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.328003549071906 0.354607725701113 no 2182 0.371454489588187 2939 5355888
SGTC_109 0132-0036 33.701 µM -0.328085075088202 0.354578934856681 no 2183 0.371423669178618 2917 67274 A color developer.
SGTC_311 1315-0136 58 µM -0.328181418245738 0.354544912422229 no 2184 0.371387248302562 3158 6759207
SGTC_215 1287-0124 461.5 µM -0.329059751382952 0.354234793119835 no 2185 0.371055262686534 3028 5560863
SGTC_1944 st076371 56.9 µM -0.329311099995749 0.354146065460418 no 2186 0.370960277512814 2958 24208455
SGTC_63 0099-0242 26.702 µM -0.329966795023284 0.353914638225226 no 2187 0.370712525990743 3134 3898502 YLR359W ADE13
SGTC_3223 9129970 49.47 µM -0.330181861194511 0.353838742475156 no 2188 0.370631275839069 2940 17248386
SGTC_271 rotenone 740 µM -0.330355631290515 0.353777424140604 no 2189 0.370565631203718 3107 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3202 9113761 49.47 µM -0.330412281280199 0.3537574348522 no 2190 0.370544231512502 3140 4798415
SGTC_631 k072-0230 41.5 µM -0.330907183099448 0.35358282293101 no 2191 0.370357298014788 3090 5773147
SGTC_2404 5161160 200 µM -0.332568055443262 0.35299705707447 no 2192 0.369730180032702 2919 2831543
SGTC_1034 k072-0165 12.7 µM -0.336019128270643 0.351781027983697 no 2193 0.368428221010419 3156 5835461
SGTC_2191 5911152 200 µM -0.338019417828159 0.351076893268498 no 2194 0.367674277419855 3045 2875902
SGTC_2731 amoxapine 43.43 µM -0.338082394824378 0.351054732618654 no 2195 0.367650548565776 3066 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3312 9133330 71.43 µM -0.341431929845409 0.349876813661387 no 2196 0.366389220577212 3149 17617324
SGTC_1073 triclabendazole 3.09 µM -0.341833988853606 0.349735519817251 no 2197 0.366237914651431 3082 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3319 9138450 16.7555 µM -0.342091468992997 0.349645045623795 no 2198 0.366141028673782 2998 2029690
SGTC_1502 4534-4282 27.7 µM -0.342141809639319 0.349627357764549 no 2199 0.36612208722841 3037 3278949
SGTC_2331 7980721 200 µM -0.344105885527678 0.348937508598299 no 2200 0.365383328439643 3054 2981221
SGTC_2155 5570423 76 µM -0.344895050341347 0.348660467910648 no 2201 0.36508663591082 3021 797402
SGTC_1175 0741-0056 27.6 µM -0.344963704157852 0.348636370420279 no 2202 0.365060828800357 3204 765927
SGTC_2397 5161689 200 µM -0.347032740373454 0.347910425624003 no 2203 0.364283361095227 3210 2259942
SGTC_907 3448-6986 75.5 µM -0.347040379086743 0.347907746525544 no 2204 0.364280491779866 3198 590582
SGTC_1531 st059297 52.4 µM -0.34740728293118 0.34777907260214 no 2205 0.364142681345483 3119 7566702
SGTC_1860 st056228 74.6 µM -0.34770364229618 0.347675151569164 no 2206 0.364031380500226 3127 688679
SGTC_1802 st050112 57.9 µM -0.348090872019607 0.347539383288441 no 2207 0.363885969629287 3025 4662563
SGTC_1052 3253-3998 198 µM -0.348626231228041 0.347351710899779 no 2208 0.363684966082163 2978 5450317
SGTC_1384 3089-0840 101 µM -0.349189936994581 0.347154141949954 no 2209 0.363473360209242 3141 1069836
SGTC_1743 st037606 46.3785 µM -0.35064243229898 0.346645259407106 no 2210 0.36292830942225 3024 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_765 1319-0117 244 µM -0.350871021068237 0.346565198370191 no 2211 0.362842556432955 3023 3487746 YGL099W LSG1
SGTC_2852 9023854 51.95 µM -0.350981826409085 0.346526392321909 no 2212 0.362800991295887 3182 19798528
SGTC_1631 benzylvanillin 81.9 µM -0.351669323253802 0.346285654418249 no 2213 0.362543134633138 3150 75506
SGTC_2708 st078559 56 µM -0.35413146927294 0.345424004971348 no 2214 0.361620179600179 3130 17250902
SGTC_2378 9074213 121.43 µM -0.354643791453655 0.345244813818805 no 2215 0.361428232493639 3043 657714
SGTC_2837 9008476 45.46 µM -0.35473924696609 0.345211430880255 no 2216 0.36139247289487 3200 2992805
SGTC_2090 5301565 104.445 µM -0.355083403506179 0.345091081602071 no 2217 0.361263554829506 3028 2056344
SGTC_3246 9135460 32.98 µM -0.357303300035367 0.344315175291016 no 2218 0.36043237988057 3108 41446951
SGTC_2322 7413319 38.22 µM -0.357761270394587 0.34415518519571 no 2219 0.360260988236171 3137 1840400
SGTC_922 1866-0035 480 µM -0.35811722517438 0.344030853092762 no 2220 0.360127794476276 3022 3156169
SGTC_1182 1222-0449 220 µM -0.358883052548086 0.343763413009238 no 2221 0.35984128917076 3105 658318
SGTC_2493 resveratrol 26.09 µM -0.359288262615171 0.343621938300656 no 2222 0.359689727013024 2989 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1077 5-fluorocytosine 377 nM -0.360063859637615 0.343351208087238 no 2223 0.359399689260732 3097 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1221 2958-7315 257 µM -0.360327341078675 0.34325925542775 no 2224 0.359301177694781 3123 4562705
SGTC_1452 4194-0072 190 µM -0.360364591784797 0.343246256013964 no 2225 0.359287250996188 3187 1343545
SGTC_2588 indole-3-carbinol 100 µM -0.360638942085573 0.343150521446831 no 2226 0.359184687050758 3161 3712 Induces cell cycle arrest.
SGTC_1564 D-Arginine 115 µM -0.361008542864353 0.343021565130837 no 2227 0.359046530423438 3080 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2207 7258803 200 µM -0.36171103545193 0.342776510925012 no 2228 0.358783989793711 3120 3666799
SGTC_549 1661-1316 519 µM -0.361831303523662 0.342734563805341 no 2229 0.35873904902108 3184 2857282
SGTC_3199 9111318 49.47 µM -0.363597977625243 0.342118606566726 no 2230 0.3580791185927 3149 8548020
SGTC_585 0kpi-0023 191 µM -0.364274539737612 0.341882831863538 no 2231 0.357826505028264 3171 64601
SGTC_76 0433-0009 400.328 µM -0.365850646975325 0.341333814489266 no 2232 0.35723826249118 3130 2841569
SGTC_1281 0884-0031 11.8 µM -0.366873811199088 0.340977587528603 no 2233 0.356856573517404 3075 1548255
SGTC_1319 1306-0155 43.7 µM -0.36807216361214 0.340560546892929 no 2234 0.356409713171717 3066 3122360
SGTC_1270 0831-1170 17.3 µM -0.370324917007501 0.339777090177174 no 2235 0.355570205192329 3069 6764716
SGTC_500 h-89 112 µM -0.370589480632272 0.339685126246445 no 2236 0.35547165914092 3208 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1448 4255-0083 152 µM -0.371092474315227 0.339510308893964 no 2237 0.355284328056983 3210 5399660
SGTC_1635 st007035 42.4 µM -0.371742520412988 0.339284434066785 no 2238 0.355042281703061 3141 3716403
SGTC_1696 st025591 34.7925 µM -0.371925910644307 0.339220720968132 no 2239 0.354974006447004 3065 2787147
SGTC_1410 3909-8106 77.9 µM -0.373574771202858 0.338648083505663 no 2240 0.354360353387554 3155 1039210
SGTC_1123 mangostin 811.285 nM -0.374678084357016 0.33826511884223 no 2241 0.353949946522494 3105 5281650 An antioxidant.
SGTC_1005 4092-0690 4.4 µM -0.376656751020872 0.337578734426297 no 2242 0.353214353639861 3097 1529343
SGTC_1449 4112-4002 201 µM -0.377074738044993 0.3374338069131 no 2243 0.353059032016719 3105 2059539
SGTC_2644 guaiazulene 100 µM -0.37722626456972 0.337381274483888 no 2244 0.353002731658039 3145 3515 A coloring agent.
SGTC_1763 st044482 94.5 µM -0.378148094700586 0.337061755360151 no 2245 0.352660290925054 3184 88505
SGTC_1061 3448-9325 110 µM -0.378931886236542 0.336790174756339 no 2246 0.352369222531296 3137 723482
SGTC_642 0335-0876 158 µM -0.380528283226586 0.336237292881454 no 2247 0.351776652895423 3098 6812350
SGTC_2387 9077560 195.08 µM -0.383696533455331 0.335141078770055 no 2248 0.350601691114144 3073 5303272
SGTC_3139 9095020 49.47 µM -0.386487988494864 0.33417639756309 no 2249 0.349567648337832 2994 25236292
SGTC_195 4234-0266 16.654 µM -0.387400058796267 0.333861437869579 no 2250 0.349230030138049 3118 2303354
SGTC_1520 flindersine 88 µM -0.387951348204886 0.333671121169362 no 2251 0.349026018887054 3327 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3314 9135860 59.4275 µM -0.387964532342081 0.333666570251583 no 2252 0.349021140473067 3220 25252478
SGTC_2640 pentamidine 10.38 µM -0.388385652824268 0.333521220208986 no 2253 0.348865329979655 3197 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_326 k292-0812 17.5 µM -0.388404582499956 0.333514687204268 no 2254 0.348858326781557 3177 3579357
SGTC_2437 5741531 144.16 µM -0.388732814257818 0.333401415975281 no 2255 0.348736902777748 3260 2262990
SGTC_607 4491-0986 66.8 µM -0.389936183283039 0.332986269001653 no 2256 0.348291868564593 3226 698981 YDR232W HEM1
SGTC_894 0960-0238 55.9 µM -0.390478169744064 0.332799357382524 no 2257 0.348091497362334 3222 6741907 YDL195W SEC31
SGTC_3082 9117008 49.47 µM -0.390756627695684 0.332703343411983 no 2258 0.347988568555411 3122 41448529
SGTC_657 3534-0529 86.7 µM -0.392283542249069 0.332177049296834 no 2259 0.347424361252371 3231 1049549
SGTC_1880 MG-132 525 µM -0.392415571063382 0.332131557371908 no 2260 0.347375591389017 3212 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1397 3532-0190 20.1 µM -0.3937978924838 0.331655412547547 no 2261 0.346865130254883 3025 5322280
SGTC_853 0419-0306 21 µM -0.393940394131808 0.331606342865657 no 2262 0.34681252328703 3085 762713
SGTC_2136 5328288 199.296 µM -0.393981475356215 0.331592197301867 no 2263 0.346797357985144 3104 262395
SGTC_1500 4488-1866 171 µM -0.394370930736462 0.331458107440383 no 2264 0.346653601136082 3226 2900003
SGTC_144 4161-2749 112.381 µM -0.395407506913512 0.33110131855949 no 2265 0.346271084897907 3134 797501 YMR168C CEP3
SGTC_1661 st013063 9.66 µM -0.396367073546421 0.330771172944763 no 2266 0.345917126346575 3110 721395
SGTC_2303 7774051 200 µM -0.397787246195824 0.330282794160218 no 2267 0.345393509615288 3274 2953184
SGTC_38 0929-0051 58.268 µM -0.399751633274078 0.329607743555703 no 2268 0.344669728981312 3228 1379719
SGTC_2770 toltrazuril 17.5 µM -0.400986025609194 0.329183835239704 no 2269 0.344215206259516 3207 68591 Kills coccidiodes.
SGTC_2118 5526350 200 µM -0.402331934005669 0.328721880849262 no 2270 0.343719877903945 3196 743594
SGTC_489 paxilline 115 µM -0.404392687626516 0.328015078115612 no 2271 0.342961988271058 3178 105008 A toxic potassium channel blocker.
SGTC_483 fpl-64176 144 µM -0.405211403724501 0.327734443384821 no 2272 0.342661061643008 3184 3423
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.405366173047732 0.32768140338583 no 2273 0.342604185968531 3198 4213774
SGTC_2862 9027634 71.43 µM -0.405677645369967 0.327574671250389 no 2274 0.342489734836764 3078 5012562
SGTC_2738 aclarubicin 5.55 µM -0.405952457972966 0.327480512989753 no 2275 0.342388766400291 3156 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1256 0570-0116 285 µM -0.40771423771937 0.326877140279472 no 2276 0.341741741700883 3140 410638
SGTC_2141 5621638 7.665 µM -0.407826739248413 0.326838626208625 no 2277 0.341700440569504 3237 2856238
SGTC_1816 st051957 91.6 µM -0.408548649473347 0.326591529467704 no 2278 0.341435460757823 3157 674121
SGTC_1983 st071813 46.9 µM -0.409011740879011 0.326433061736639 no 2279 0.341265522481544 3184 11838595
SGTC_3349 9149703 23.001 µM -0.412451979248668 0.325256810332939 no 2280 0.34000408555521 3135 4910494
SGTC_3124 9127567 49.47 µM -0.412758619306406 0.325152051311385 no 2281 0.339891736059909 3288 17592030
SGTC_2720 fluspirilene 36.88 µM -0.413749492152239 0.324813628828918 no 2282 0.339528788560988 3204 3396 An atypical antipsychotic.
SGTC_3077 9117319 49.47 µM -0.415102363559816 0.32435180286626 no 2283 0.339033484637993 3178 17154678
SGTC_727 3032-0951 202 µM -0.415404469190843 0.324248710765162 no 2284 0.338922917768515 3157 3652836
SGTC_2947 9072639 7.68 µM -0.415762668978823 0.324126494258236 no 2285 0.338791839120622 3213 16488146
SGTC_66 0109-0187 42.4 µM -0.41706162102485 0.323683455436224 no 2286 0.338316668010334 3220 759417
SGTC_529 4076-0302 30.3 µM -0.419468581598999 0.322863164199317 no 2287 0.337436855808114 3143 5816522
SGTC_1864 st057645 30.4 µM -0.420626639873333 0.322468804914289 no 2288 0.337013868826072 3245 688666
SGTC_946 3434-1334 87.4 µM -0.421086941157966 0.322312111681841 no 2289 0.336845798502897 3241 4047976
SGTC_361 000s-0510 1.45 µM -0.421290468762982 0.322242837996762 no 2290 0.33677149462449 3202 660
SGTC_230 MPP+ 141.667 µM -0.423039110870386 0.321647915912983 no 2291 0.33613336295899 3202 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2043 5101342 149 µM -0.423135035416021 0.321615293725916 no 2292 0.33609837086919 3164 678451
SGTC_2420 aureobasidin a 50 nM -0.42361616772184 0.321451690165854 no 2293 0.335922881177349 3368 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2847 9005661 71.43 µM -0.423780439845654 0.321395839230197 no 2294 0.335862972240878 3224 2991449
SGTC_829 1635-0120 117 µM -0.4237830356703 0.321394956707292 no 2295 0.335862025594592 3268 285054
SGTC_2516 gossypol 71.55 µM -0.424595003166975 0.321118955241858 no 2296 0.335565968124023 3285 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_719 2810-4230 27.3 µM -0.424869959066135 0.321025515470415 no 2297 0.335465737542984 3197 721079
SGTC_968 1309-0633 340 µM -0.425046551497556 0.320965509071823 no 2298 0.335401369895642 3255 3761976
SGTC_1402 3909-7673 35.9 µM -0.426699953295178 0.320403907436305 no 2299 0.334798942290899 3166 5328014
SGTC_2076 5212012 200 µM -0.42670216021154 0.320403158099913 no 2300 0.334798138470324 3179 604802
SGTC_2826 7992541 19.48 µM -0.426708514368304 0.320401000613586 no 2301 0.334795824113193 3187 2985066
SGTC_3239 9133757 49.47 µM -0.427578853039644 0.320105543758405 no 2302 0.334478882367003 3192 17036923
SGTC_3138 9097216 49.47 µM -0.428222396852677 0.319887151057231 no 2303 0.334244605855569 3229 25237486
SGTC_10 0279-0212 42.575 µM -0.428995522238115 0.319624866152317 no 2304 0.333963241668932 3188 39851 YBR002C RER2
SGTC_1114 scopoletin 1.73284 µM -0.428996624890952 0.3196244921387 no 2305 0.333962840446135 3273 5280460 A coumarin with genotoxic properties.
SGTC_1921 5740136 50 µM -0.42988701885274 0.319322535445934 no 2306 0.333638914373413 3301 1774243
SGTC_828 2074-0507 139 µM -0.431270074493147 0.318853741449055 no 2307 0.333136003471029 3297 X828
SGTC_1206 3978-0017 132 µM -0.431556839534022 0.318756577161012 no 2308 0.33303176660305 3383 3873677
SGTC_2587 piperic acid 92.2 µM -0.431735792998903 0.318695948864893 no 2309 0.332966724942648 3181 5370536
SGTC_845 0330-0138 4.51 µM -0.431964978806032 0.318618309258026 no 2310 0.332883433389061 3216 9039800
SGTC_2539 epi(13)torulosol 80 µM -0.432858261645021 0.318315774359859 no 2311 0.332558871968806 3255 6708597
SGTC_2177 5811945 192 µM -0.433420689382206 0.31812535480855 no 2312 0.332354586328499 3295 5343475
SGTC_874 0599-0792 117 µM -0.435002802404829 0.317589961209608 no 2313 0.331780196648685 3318 765305
SGTC_495 decylubiquinone 155 µM -0.436087870442104 0.317222990030197 no 2314 0.331386488644592 3229 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_219 mitoxanthrone 164.414 µM -0.43616896007307 0.317195572639354 no 2315 0.331357073414596 3194 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2255 7941087 197.44 µM -0.43626201309613 0.317164111516356 no 2316 0.331323319751005 3299 935561
SGTC_370 0180-0345 38.7 µM -0.436655482306467 0.317031094625443 no 2317 0.331180609528037 3073 3989527
SGTC_2504 purpurogallin 52.29 µM -0.437064974841063 0.316892685965606 no 2318 0.331032113723721 3147 5281571 An antioxidant.
SGTC_1636 st007707 68.9 µM -0.438158269935413 0.316523277298024 no 2319 0.330635778293819 3361 403051
SGTC_1620 st003704 16.5 µM -0.439081929799509 0.316211328484565 no 2320 0.330301086016836 3309 2834414
SGTC_1672 st016598 6.51 µM -0.439580056791497 0.316043149688438 no 2321 0.33012064379135 3192 4665860 YNL267W PIK1
SGTC_1040 k898-0338 155 µM -0.441224601812013 0.315488184964465 no 2322 0.329525202193333 3346 20969351
SGTC_2399 5884133 200 µM -0.441983132650436 0.315232352816442 no 2323 0.329250705856827 3179 722445
SGTC_2528 xanthyletin 44.79 µM -0.442391945480662 0.315094507918587 no 2324 0.329102803253008 3149 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3235 9132602 49.47 µM -0.442796588796307 0.314958094263883 no 2325 0.328956435458332 3309 4912240
SGTC_1952 st077036 64.1 µM -0.442932981531039 0.31491211913032 no 2326 0.328907105314213 3244 2937007
SGTC_534 k292-0788 63.4 µM -0.443598755307464 0.31468774191618 no 2327 0.328666352900917 3344 4146317
SGTC_1459 k035-0031 35.7 µM -0.447306051918331 0.313439572062686 no 2328 0.327327048975294 3144 3877128 YMR208W ERG12
SGTC_2983 9022671 12.99 µM -0.447898711071231 0.313240233450168 no 2329 0.327113149329839 3355 6405161
SGTC_185 k048-0037 25.491 µM -0.449266697478198 0.312780324891113 no 2330 0.326619639219866 3311 6827589
SGTC_3271 9137798 49.47 µM -0.451504872798087 0.312028492563384 no 2331 0.325812856936873 3272 6498326
SGTC_1467 k284-1082 293 µM -0.452240679020429 0.311781496365916 no 2332 0.32554780289276 3271 3334705
SGTC_1695 st026914 34.495 µM -0.453125035417739 0.311484746687148 no 2333 0.325229354413284 3187 3289191
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.453211425089775 0.311455764813361 no 2334 0.325198253136386 3294 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1368 1852-0141 284 µM -0.453371262464359 0.311402145898305 no 2335 0.325140713051449 3297 2838987
SGTC_2451 5856223 45.7 µM -0.454766968438191 0.31093411358822 no 2336 0.324638448155226 3210 2179896
SGTC_850 0388-0143 75.9 µM -0.455036828352197 0.310843654727306 no 2337 0.324541371921635 3201 67273
SGTC_106 0092-0003 11.579 µM -0.455065720806715 0.310833970459272 no 2338 0.324530979195959 3239 1072148
SGTC_1026 k007-1105 30.6 µM -0.455443328686316 0.310707414655947 no 2339 0.324395164772221 3273 7066794
SGTC_173 1273-0061 2.693 µM -0.455546640011703 0.310672793623314 no 2340 0.324358010802127 3278 2847414 YPL266W DIM1
SGTC_2868 9035608 32.47 µM -0.458299660573536 0.309750837305753 no 2341 0.323368583979627 3193 6462614
SGTC_1116 jasmonic acid 1.58368 µM -0.459409617219882 0.309379462855885 no 2342 0.322970021659548 3320 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_119 0121-0043 24.815 µM -0.461404674766645 0.308712436682464 no 2343 0.322254149115171 3320 1092378
SGTC_3172 9105863 49.47 µM -0.461622427631029 0.308639671470361 no 2344 0.322176054207162 3256 2348785
SGTC_1623 st003709 20.3 µM -0.462318806780507 0.30840701693416 no 2345 0.321926357429509 3206 16192618
SGTC_2260 7964312 200 µM -0.463887113962382 0.307883340216409 no 2346 0.321364312777411 3353 231951
SGTC_2589 lobaric acid 100 µM -0.464444192808746 0.307697418921791 no 2347 0.321164767060988 3200 73157 A novel microtubule depolymerizer.
SGTC_1218 1348-1416 30.7 µM -0.464786755034518 0.307583115609498 no 2348 0.32104208685529 3229 6787668
SGTC_470 aa-861 153 µM -0.465149467578746 0.307462109065359 no 2349 0.320912211599152 3248 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_654 1124-0271 80.9 µM -0.465533527241351 0.307334003627591 no 2350 0.320774716535017 3228 5403748
SGTC_2017 5132927 60.65 µM -0.465679249623977 0.307285403189773 no 2351 0.320722553706996 3195 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2608 thymoquinone 42.66 µM -0.466285507490473 0.30708324410929 no 2352 0.320505575464379 3304 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_589 1227-0070 34.1 µM -0.469787465061051 0.305916651450391 no 2353 0.31925343543682 3341 2841384
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.470091819883642 0.305815355691011 no 2354 0.319144709102551 3232 16623 A steroid.
SGTC_2358 9037157 4 µM -0.472623313845131 0.304973396824158 no 2355 0.3182409731885 3307 2388925
SGTC_2430 5571206 200 µM -0.4736323751961 0.304638076651056 no 2356 0.317881042213312 3385 1731771
SGTC_3083 9117465 49.47 µM -0.477811718089045 0.30325099297375 no 2357 0.316392110037629 3300 16420915
SGTC_648 0375-0473 33.3 µM -0.477978551849893 0.303195681101306 no 2358 0.316332735382233 3249 1713139
SGTC_905 2-aminofluorene 215 µM -0.47849782717658 0.303023550039253 no 2359 0.316147960207881 3296 1539 An established DNA mutagen. YPR165W RHO1
SGTC_381 3461-2219 42.7 µM -0.479385775697768 0.30272931135658 no 2360 0.315832105416644 3322 2883159
SGTC_3120 9124077 49.47 µM -0.479729296956693 0.302615513376633 no 2361 0.315709946505613 3312 18774327 YGL155W CDC43
SGTC_2131 toluylene red 5.2905 µM -0.480023838398321 0.302517956164361 no 2362 0.315605221238682 3228 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2622 2-methoxyxanthone 59.94 µM -0.480052759507445 0.302508377753739 no 2363 0.31559493903266 3241 71034 A hepatoprotective.
SGTC_1028 k015-0029 4.8 µM -0.480251038203262 0.302442713298755 no 2364 0.31552444964716 3245 4588309
SGTC_3033 9090887 49.47 µM -0.481753464048657 0.301945358996275 no 2365 0.314990545606992 3262 19325384
SGTC_101 0490-5701 117.494 µM -0.482095843392773 0.301832071157525 no 2366 0.314868931242354 3321 4661669
SGTC_1036 k216-0215 33.5 µM -0.482194750003576 0.301799348101528 no 2367 0.314833802997534 3301 622330
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.482950370664329 0.301549405149789 no 2368 0.314565487695444 3335 66535 A nucleotide analog.
SGTC_3099 9120367 49.47 µM -0.483173162810806 0.301475728113326 no 2369 0.314486394536237 3316 24824940
SGTC_1965 Pectolinarigenin 58.4 µM -0.483332468793624 0.301423050825959 no 2370 0.314429844740124 3260 5320438 An anti-inflammatory.
SGTC_2323 6148992 148.28 µM -0.483900114347416 0.301235382665799 no 2371 0.314228379613671 3219 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_532 1548-0774 215 µM -0.483949761902282 0.301218971290167 no 2372 0.314210761651919 3462 5932993
SGTC_296 1222-0039 74.9 µM -0.484480721180898 0.301043483866838 no 2373 0.314022371594319 3277 5984176
SGTC_2379 9035213 200 µM -0.485043181211329 0.300857635406975 no 2374 0.313822857584885 3378 646551
SGTC_1131 3454-3128 32.3 µM -0.485587667537919 0.300677775143919 no 2375 0.313629770991827 3357 710982
SGTC_1604 st002052 72.4 µM -0.487265766875896 0.300123753824803 no 2376 0.313035002055914 3383 6254834 YHR062C RPP1
SGTC_2466 5983409 37.09 µM -0.487592573423956 0.300015912995198 no 2377 0.312919228490037 3274 2879657
SGTC_1201 1889-3372 45.9 µM -0.489115551716979 0.299513586393646 no 2378 0.31237994593845 3231 5392199
SGTC_2878 9043973 25.97 µM -0.492901022730333 0.298266672413981 no 2379 0.311041262307911 3385 6465167
SGTC_126 0417-1624 672.48 µM -0.493289313314847 0.298138905332429 no 2380 0.31090408915356 3422 41912 YDL195W SEC31
SGTC_1261 0712-0010 12.7 µM -0.494355995765972 0.29778804168592 no 2381 0.310527392729511 3434 2840123
SGTC_18 0111-0177 500 nM -0.494468593101619 0.297751016058888 no 2382 0.310487640824638 3343 721752
SGTC_2871 9038510 12.99 µM -0.497541322479476 0.296741415488515 no 2383 0.309403685242931 3426 4945164
SGTC_3290 9121031 71.43 µM -0.497838595372244 0.296643824332982 no 2384 0.309298905090974 3291 17014854
SGTC_1648 st011736 69.8 µM -0.499178369957219 0.296204174798702 no 2385 0.308826865568766 3417 2855514
SGTC_1690 st023502 41.2 µM -0.499407154260924 0.296129128690661 no 2386 0.308746290080418 3364 24207482
SGTC_1997 st073024 93.8 µM -0.499693088235647 0.296035348544934 no 2387 0.308645600006003 3370 686268
SGTC_2083 5306046 65.942 µM -0.500887647779917 0.295643706427158 no 2388 0.308225098100769 3313 539837
SGTC_315 k915-0449 187 µM -0.50229387888025 0.295182972204595 no 2389 0.307730407170482 3345 20970215 YNL149C PGA2
SGTC_2996 9066192 71.4286 µM -0.502572157204834 0.29509183694984 no 2390 0.307632554422605 3304 6472854
SGTC_2800 7887935 81.82 µM -0.503960514121113 0.294637348256084 no 2391 0.307144562352068 3379 2961002
SGTC_2071 5230951 39.92 µM -0.504129351726596 0.294582100071332 no 2392 0.307085241068364 3415 1799272
SGTC_1103 duloxetine 36.1 µM -0.504308170292684 0.294523591061571 no 2393 0.307022418468395 3403 60835 A selective serotonin reuptake inhibitor.
SGTC_3323 9138564 53.9225 µM -0.50451096780398 0.294457242688371 no 2394 0.30695117843275 3426 43912313 YNL103W MET4
SGTC_1142 3253-1408 9.78 µM -0.505233263850586 0.294220988319561 no 2395 0.306697504778375 3402 256655
SGTC_687 k029-0044 34.9 µM -0.505263555652619 0.294211082148176 no 2396 0.306686868181343 3383 5829338
SGTC_3035 9091303 49.47 µM -0.505555086651506 0.29411575215157 no 2397 0.306584508948557 3366 25237002
SGTC_1017 4239-0030 168 µM -0.506247350464094 0.293889440618395 no 2398 0.306341509166733 3295 1149593
SGTC_1169 aniline yellow 25.8 µM -0.506339240699484 0.293859406363665 no 2399 0.30630926007798 3298 6051 A DNA damaging agent.
SGTC_3217 9129673 49.47 µM -0.510843786364702 0.292388842926846 no 2400 0.304730223009439 3428 17248312
SGTC_1326 1431-2094 10.8 µM -0.511604599833981 0.292140804320858 no 2401 0.304463882772855 3239 616278
SGTC_1910 st062352 60.4 µM -0.512113238030341 0.291975033933544 no 2402 0.304285880088016 3282 2245730
SGTC_227 fluconazole 33.516 µM -0.514036175061489 0.291348725236346 no 2403 0.303613349546072 3339 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3140 9094243 49.47 µM -0.514326284184664 0.291254289924859 no 2404 0.303511944035479 3416 19291112
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.517304070347319 0.290285798400548 no 2405 0.302471956557085 3273 4000243
SGTC_2224 6650123 117.647 µM -0.517769729684913 0.290134484412456 no 2406 0.302309470276615 3347 2908370
SGTC_2139 5578692 56.4705 µM -0.518874318348715 0.289775701005641 no 2407 0.301924193928536 3359 650991 YMR113W FOL3
SGTC_2289 7946404 165.07 µM -0.519537161071112 0.289560501870464 no 2408 0.30169310285414 3310 1246120 YPR165W RHO1
SGTC_158 k038-0087 26.446 µM -0.520170374121181 0.289354992441962 no 2409 0.301472416071687 3282 X158
SGTC_2470 5664817 21.68 µM -0.522727091009376 0.288525907232621 no 2410 0.300582091461298 3408 2859561
SGTC_2477 5967686 25.23 µM -0.523009498988713 0.288434397433702 no 2411 0.300483821480391 3279 776118
SGTC_591 4299-0174 154 µM -0.523222770696328 0.288365299208265 no 2412 0.300409618583167 3324 5509088
SGTC_3287 9117173 37.0625 µM -0.526449842552193 0.28732070898713 no 2413 0.29928784638121 3328 2789709
SGTC_3328 9140624 29.0385 µM -0.529148053708401 0.286448685498227 no 2414 0.298351374326959 3426 4904392
SGTC_981 1488-1094 54.9 µM -0.530184780498963 0.286113964446566 no 2415 0.297991911097305 3378 3449522
SGTC_1199 1638-0010 4.46 µM -0.531441849263212 0.285708352481294 no 2416 0.297556313905626 3300 3111136
SGTC_2716 st080858 38.6235 µM -0.531520504662796 0.28568298224113 no 2417 0.297529068044443 3426 5296050
SGTC_501 nsc-95397 161 µM -0.53186526069517 0.285571794087987 no 2418 0.297409659612609 3457 262093
SGTC_2682 pyrogallin 40.03 µM -0.535390178223348 0.284436147397185 no 2419 0.296190040185914 3374 822798 An ATP competetive kinase inhibitor.
SGTC_760 0568-0725 82.9 µM -0.537061610657961 0.283898405791612 no 2420 0.295612528566747 3445 3916171
SGTC_3279 9140807 49.47 µM -0.53801781789247 0.283590988981029 no 2421 0.295282373768671 3413 45595718
SGTC_343 4130-2827 29.8 µM -0.538316704962993 0.283494930708045 no 2422 0.295179210251475 3366 1118244
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.538956330390404 0.283289416131735 no 2423 0.294958493648099 3425 279621
SGTC_2779 methotrexate 400 µM -0.540859538477877 0.282678329624539 no 2424 0.294302200684949 3470 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3242 9133940 49.47 µM -0.541642769593081 0.282427032062296 no 2425 0.294032311118662 3476 17248444
SGTC_2440 5628896 157.78 µM -0.542887933222697 0.282027746042977 no 2426 0.293603482308579 3367 5522048
SGTC_1501 4491-0275 38.4 µM -0.54324238554104 0.281914133718327 no 2427 0.29348146347427 3437 5104718
SGTC_1380 2291-0730 164 µM -0.54694579141872 0.280728404536622 no 2428 0.292207987453075 3368 2999191
SGTC_1879 gemcitabine 100 µM -0.547397494717459 0.2805839467109 no 2429 0.292052838040777 3400 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1386 3228-0095 33.8 µM -0.548378328846131 0.280270393108783 no 2430 0.291716076792175 3442 870181
SGTC_761 k216-0224 480 µM -0.549634627511239 0.279869026934008 no 2431 0.291285001626264 3520 1340404
SGTC_1350 1495-0454 146 µM -0.549903443106339 0.279783181119169 no 2432 0.291192801260921 3485 1069057
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.550285654436226 0.279661144563387 no 2433 0.291061731051227 3435 140250 A respiratory chain inhibitor.
SGTC_2349 9023730 187.07 µM -0.55048625335081 0.279597105517619 no 2434 0.290992951493057 3469 4126287
SGTC_188 3229-0966 278.469 µM -0.551808881025216 0.279175049150847 no 2435 0.290539650977674 3477 5722370
SGTC_319 1348-1596 45.5 µM -0.552403261674389 0.2789854805576 no 2436 0.290336048218362 3498 5380505
SGTC_2250 alverine citrate 130 µM -0.555343804776998 0.278048561599782 no 2437 0.289329760971376 3402 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_869 0564-0080 44.1 µM -0.555987059681042 0.27784381186036 no 2438 0.289109850504763 3402 6843321
SGTC_2156 5649887 115 µM -0.556937066631626 0.277541556826772 no 2439 0.288785214123874 3473 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2056 5235370 200 µM -0.557527424225543 0.277353809129152 no 2440 0.288583563621265 3364 5511916
SGTC_824 1304-0008 100 µM -0.557604909315457 0.27732917164642 no 2441 0.288557101694314 3402 768245
SGTC_1625 st003711 30.1 µM -0.558063092132795 0.277183507803186 no 2442 0.288400651088314 3517 24207034 YER133W GLC7
SGTC_1330 1469-0054 61.8 µM -0.561887907862259 0.275968998574453 no 2443 0.28709619644068 3469 7102664
SGTC_709 3807-1509 243 µM -0.563272292857076 0.27553005429001 no 2444 0.286624741043215 3479 1886677 YPL242C IQG1
SGTC_1291 0993-0025 5.79 µM -0.563921558852302 0.275324311120395 no 2445 0.286403758613656 3508 4353356
SGTC_1985 st071382 65.5 µM -0.566788359800357 0.274416767626539 no 2446 0.285428989970654 3484 6123237
SGTC_3338 9144300 39.5675 µM -0.567997710990385 0.274034366480549 no 2447 0.285018261112052 3406 4901274
SGTC_1513 0337-0559 19 µM -0.568146921668936 0.273987203788787 no 2448 0.284967604607443 3355 775073
SGTC_1288 0973-0013 65.5 µM -0.568163837558615 0.273981857247105 no 2449 0.284961861992928 3483 4315430
SGTC_2499 avocadenofuran 51.48 µM -0.568547657988858 0.273860558426551 no 2450 0.284831577280894 3334 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1866 st057638 64 µM -0.571895380227903 0.272803704463724 no 2451 0.283696427001214 3418 688802
SGTC_184 1494-0393 24.714 µM -0.574430889535295 0.272004609531908 no 2452 0.282838127503604 3405 3090647
SGTC_998 3996-0085 177 µM -0.574714791707636 0.271915207016126 no 2453 0.28274210100263 3427 715391
SGTC_566 0958-0068 16.5 µM -0.575054392985891 0.271808283718196 no 2454 0.282627255526986 3494 6815365
SGTC_1207 2099-0101 141 µM -0.575111503581018 0.271790304530287 no 2455 0.282607944217242 3466 5837381
SGTC_837 0091-0265 12.5 µM -0.576152046618221 0.271462831166699 no 2456 0.282256207310048 3410 759367
SGTC_2467 5474540 200 µM -0.576278410834698 0.271423075978769 no 2457 0.282213506503209 3442 5413519
SGTC_1346 1488-2224 62.4 µM -0.577599638053827 0.271007581179043 no 2458 0.281767225683521 3495 3722427
SGTC_2658 polymyxin b sulfate 77.05 µM -0.577613580242903 0.271003198381752 no 2459 0.281762518140135 3464 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1185 1319-0113 81.3 µM -0.577861026409065 0.270925418317516 no 2460 0.281678974902221 3479 4672763
SGTC_96 0929-0093 37.281 µM -0.579594088386508 0.270380975175561 no 2461 0.281094190262111 3408 6991579
SGTC_3189 9110682 49.47 µM -0.579832936704982 0.270305983638443 no 2462 0.281013642019934 3476 17122418
SGTC_2891 9063876 19.48 µM -0.580164328637043 0.270201953280148 no 2463 0.280901903218624 3430 6472478
SGTC_1468 k284-1086 134 µM -0.580589996731706 0.270068357188689 no 2464 0.28075840787897 3505 15996457
SGTC_569 4130-2812 160 µM -0.580790385233922 0.270005476624617 no 2465 0.28069086795359 3426 743552
SGTC_1776 st049249 45.9 µM -0.581928860882501 0.269648369730569 no 2466 0.280307299760917 3454 1822314
SGTC_2153 5569715 200 µM -0.582422130250285 0.269493718890525 no 2467 0.280141189346213 3491 2054701
SGTC_2974 9094440 9.66 µM -0.58252620709973 0.269461094180037 no 2468 0.280106147149659 3531 25236134
SGTC_1045 1348-1485 165 µM -0.5847360262956 0.268768855268174 no 2469 0.279362613017851 3498 6810614
SGTC_1210 3013-0140 750 nM -0.584948939400578 0.268702206190742 no 2470 0.279291025177983 3524 905973
SGTC_2128 5255449 168.493 µM -0.585954154617043 0.268387651667503 no 2471 0.278953161793627 3449 736008
SGTC_414 piperonyl butoxide 100 µM -0.586388638283891 0.268251749266215 no 2472 0.278807188839048 3398 5794 A potent inhibitor of cytochrome P450.
SGTC_2415 st077333 57.7 µM -0.586680537207295 0.268160465478022 no 2473 0.278709140791191 3573 2766255
SGTC_192 3455-0609 60.9 µM -0.587239639298378 0.267985664514129 no 2474 0.278521386814017 3548 3769639
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.587995346234267 0.267749487073424 no 2475 0.278267708256903 3485 676296 Flavone; oxidizing agent.
SGTC_1313 1220-0047 237 µM -0.588241492002632 0.267672582974808 no 2476 0.278185105443339 3486 3528706
SGTC_1534 6-azauridine 81.6 µM -0.588326073901147 0.267646159355759 no 2477 0.278156723792472 3474 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2684 capsaicin 100 µM -0.588352577770442 0.267637879744227 no 2478 0.278147830648683 3508 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2352 9027995 87.8 µM -0.588588325334819 0.267564239641279 no 2479 0.278068733698371 3436 2997347
SGTC_2338 7999974 200 µM -0.58997149999481 0.267132385402336 no 2480 0.277604878411711 3542 315925
SGTC_1194 1488-0194 225 µM -0.590341040991716 0.267017067052175 no 2481 0.277481014814468 3471 1391452
SGTC_689 0833-0039 98 µM -0.590645552444853 0.266922060610415 no 2482 0.277378968273122 3481 5374726
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.591904324918942 0.266529509552177 no 2483 0.276957328768095 3497 616764
SGTC_1243 0416-0003 5.65 µM -0.593473730405306 0.26604049616169 no 2484 0.276432079254339 3439 2141977
SGTC_1053 3366-3204 134 µM -0.593878523100243 0.265914439966127 no 2485 0.276296682300552 3453 3632071 YPR165W RHO1
SGTC_921 1561-0023 372 µM -0.594463304049077 0.265732387216745 no 2486 0.276101139506481 3514 24050882
SGTC_1943 st076331 65.2 µM -0.594611462302443 0.265686272942051 no 2487 0.276051608191362 3554 24208415
SGTC_2966 9084041 48.03 µM -0.599622754034211 0.264128901223164 no 2488 0.274378839612117 3372 17741380
SGTC_1958 st076513 41.9 µM -0.600111862566319 0.263977149206266 no 2489 0.274215843641798 3437 732122 YGL099W LSG1
SGTC_1401 3807-4679 7.6 µM -0.60023871048343 0.263937800316921 no 2490 0.274173579240921 3512 3291456
SGTC_150 3970-0969 77.2 µM -0.601029901699121 0.263692436148446 no 2491 0.273910035239322 3522 6615640
SGTC_3053 9095903 49.47 µM -0.602011488526265 0.263388188303997 no 2492 0.273583245050237 3543 17174018
SGTC_1212 0520-0165 585 µM -0.603376748525357 0.262965317197981 no 2493 0.273129043300462 3680 5403258
SGTC_78 0336-0123 156.75 µM -0.603677562867835 0.262872190641507 no 2494 0.273029017093366 3379 6765896
SGTC_160 3453-0671 289.699 µM -0.604581994856552 0.262592296834723 no 2495 0.272728386525946 3472 5322268
SGTC_412 gemfibrozil 100 µM -0.604924548870799 0.262486326767345 no 2496 0.272614565467221 3515 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2616 abietic acid 100 µM -0.605417440393711 0.262333887781418 no 2497 0.272450832867245 3547 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2601 securinine 100 µM -0.606377809946374 0.262036999856594 no 2498 0.27213195006715 3459 442872 A GABA receptor antagonist.
SGTC_1250 0485-0349 40.2 µM -0.606546234838112 0.261984950868277 no 2499 0.272076045097551 3464 6842794 YDL195W SEC31
SGTC_1276 0871-0068 94.2 µM -0.606560698104517 0.261980481476893 no 2500 0.272071244597947 3471 3414906
SGTC_170 4197-0004 226 µM -0.606643825764114 0.261954794396821 no 2501 0.272043654531182 3534 218692
SGTC_210 3551-0445 56.827 µM -0.608557018287525 0.261363960413833 no 2502 0.271409050749642 3580 2865180 YOR207C RET1
SGTC_2525 harmine 47.85 µM -0.609424835030473 0.261096186225888 no 2503 0.27112144027691 3462 5280953 A monoamine oxidase inhibitor
SGTC_1033 k072-0102 21.3 µM -0.610219483982971 0.260851112490889 no 2504 0.270858212332627 3530 5965931
SGTC_1729 st035615 45.989 µM -0.610755372757054 0.260685908527756 no 2505 0.270680770892858 3466 17385451
SGTC_1624 st003710 6.25 µM -0.611637521316916 0.260414076810222 no 2506 0.270388803719749 3548 24207033
SGTC_2138 5575593 77.673 µM -0.612074925019596 0.260279346192425 no 2507 0.270244093390308 3514 762213
SGTC_895 0964-0006 13.7 µM -0.613092010943659 0.259966198745589 no 2508 0.269907751199247 3540 6738897
SGTC_2789 5281112 71.43 µM -0.613598523372037 0.259810322705411 no 2509 0.269740329778235 3505 765948
SGTC_3102 9121669 49.47 µM -0.613988486459337 0.259690346862599 no 2510 0.269611467745775 3502 41905072
SGTC_1430 4049-0248 69.1 µM -0.615048496994071 0.259364369138087 no 2511 0.269261346652719 3576 22774488
SGTC_1968 st069590 43.6 µM -0.616401643346581 0.258948552769125 no 2512 0.268814734509404 3513 6384066
SGTC_303 1348-1668 34.2 µM -0.6170243197958 0.258757322746584 no 2513 0.268609342365967 3530 5380509
SGTC_2715 st079500 56.4 µM -0.617204170364871 0.258702102486652 no 2514 0.268550032669714 3519 28246688
SGTC_1406 3909-7906 11.9 µM -0.617899245663433 0.258488748016544 no 2515 0.268320878139304 3554 X1406
SGTC_3026 9090633 49.47 µM -0.618977045166076 0.258158096062441 no 2516 0.267965740542469 3511 25236842
SGTC_2766 oltipraz 83.91 µM -0.620007065944288 0.257842306916481 no 2517 0.267626567478551 3547 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1413 3910-0535 34.4 µM -0.620133792825701 0.257803468181065 no 2518 0.267584852843472 3552 2876951
SGTC_718 1130-0073 349 µM -0.620699792301058 0.25763004005169 no 2519 0.267398583052548 3626 6740020
SGTC_2807 7945238 51.95 µM -0.62157242476684 0.257362775131366 no 2520 0.267111528900675 3553 17148797
SGTC_157 1348-1695 65.819 µM -0.623229296553172 0.256855714618861 no 2521 0.266566926156836 3564 5380510
SGTC_1999 st074831 12.5 µM -0.62361019385267 0.256739220312399 no 2522 0.266441807172729 3486 17112523
SGTC_2171 5739187 198.077 µM -0.624281843550049 0.256533868808831 no 2523 0.266221252842721 3479 2262761
SGTC_986 1493-0483 84 µM -0.625697614311163 0.256101288678131 no 2524 0.265756649179702 3523 40079
SGTC_670 4204-0025 119 µM -0.626781795289619 0.25577028118728 no 2525 0.265401139145144 3536 719039
SGTC_2101 5377231 179.231 µM -0.62841959664942 0.255270673656316 no 2526 0.264864551416312 3552 2844213
SGTC_2256 7954252 200 µM -0.629233591522674 0.255022556327804 no 2527 0.264598070115548 3512 2972920
SGTC_488 nitrendipine 139 µM -0.629251330315557 0.25501715069401 no 2528 0.264592264402975 3582 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1993 st073995 70.8 µM -0.629774315876675 0.254857805548871 no 2529 0.264421126082949 3563 3098394
SGTC_3042 9091578 49.47 µM -0.629817250472717 0.25484472639494 no 2530 0.264407078953882 3541 25236497
SGTC_1554 st069299 38.7 µM -0.631461835256061 0.254344001587341 no 2531 0.263869297906389 3561 24207999
SGTC_1139 k015-0024 46.9 µM -0.631954900060904 0.254193979269403 no 2532 0.263708173891834 3563 2766652
SGTC_863 0466-0191 129 µM -0.634159411231428 0.253523791845582 no 2533 0.262988396679922 3567 765160 YPR165W RHO1
SGTC_1731 st035964 63 µM -0.634774135321778 0.253337076918949 no 2534 0.262787867264213 3495 6739575
SGTC_2159 5658611 73.75 µM -0.635106123666734 0.25323626958784 no 2535 0.262679601731832 3591 793844
SGTC_2924 9010168 62.78 µM -0.635789077587873 0.253028958887631 no 2536 0.262456953738173 3586 2993929
SGTC_446 go6976 132 µM -0.636678931360535 0.252758977752487 no 2537 0.262166999897047 3553 3501 A protein kinase C inhibitor.
SGTC_2968 9090663 33.37 µM -0.637291451621597 0.252573227624168 no 2538 0.261967509038877 3501 25236811
SGTC_1794 st048918 76.9 µM -0.638192039328805 0.252300250115859 no 2539 0.26167433930494 3523 672303
SGTC_2942 9052777 62.25 µM -0.642382572178591 0.251032104584727 no 2540 0.260312406302758 3651 6469503
SGTC_1411 3909-8223 150 µM -0.64367841780705 0.250640637587803 no 2541 0.259891993928529 3596 X1411
SGTC_473 2-arachidonoylglycerol 10 µM -0.644703826116127 0.250331097366037 no 2542 0.259559568186494 3511 5282280 An endocannabinoid.
SGTC_2926 9010726 65.15 µM -0.645022342899602 0.250234987907434 no 2543 0.259456353367831 3576 2994293
SGTC_619 1652-1634 108 µM -0.645624195973769 0.25005343780582 no 2544 0.259261381798501 3538 5400454
SGTC_201 4262-0159 12.803 µM -0.648585775391491 0.249161090830792 no 2545 0.258303076112071 3545 1341029
SGTC_1364 1653-0028 37.6 µM -0.649172120122365 0.248984621665621 no 2546 0.25811356504796 3566 5718652
SGTC_838 0109-0203 71.4 µM -0.649523089164774 0.248879024142006 no 2547 0.258000163694181 3603 759422
SGTC_792 4534-1957 155 µM -0.649667875254922 0.248835468692136 no 2548 0.257953389495818 3562 1717904
SGTC_959 1222-0044 107 µM -0.650072860768081 0.248713659990133 no 2549 0.257822579348914 3583 6083612
SGTC_1098 clofazimine 15.1 µM -0.650979685064121 0.248441026932995 no 2550 0.257529800382763 3633 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1269 0831-0796 3.05 µM -0.65143359861232 0.248304619498336 no 2551 0.257383313897403 3607 927758
SGTC_132 0417-1715 25.805 µM -0.651715836061696 0.248219823293733 no 2552 0.25729225237081 3641 6769098
SGTC_1309 pyrazolanthrone 13.4 µM -0.653620030318211 0.247648125649205 no 2553 0.256678318082459 3626 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_830 4076-0286 57.8 µM -0.654325798094873 0.247436411242818 no 2554 0.256450964275785 3646 6866659
SGTC_2943 9068529 45.32 µM -0.654465706639407 0.247394453327509 no 2555 0.25640590704298 3631 3270634
SGTC_2882 9058044 58.44 µM -0.654629879813895 0.247345223413233 no 2556 0.256353040701361 3566 18076804
SGTC_3094 9117742 49.47 µM -0.65617117307156 0.246883297802827 no 2557 0.255856997210536 3569 17149698
SGTC_2484 5809818 12.04 µM -0.656524659074623 0.246777423169789 no 2558 0.255743303388956 3595 2870548
SGTC_392 N-ethylmaleimide 8.33 µM -0.656770023802539 0.246703946859084 no 2559 0.255664400772515 3582 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3340 9146634 11.102 µM -0.657023934056552 0.246627923862255 no 2560 0.255582763533468 3607 4907387
SGTC_1021 4476-0760 85.3 µM -0.657070909521387 0.246613860364272 no 2561 0.255567661472082 3566 746768
SGTC_790 1575-0012 79.1 µM -0.659722445275925 0.245820741386407 no 2562 0.254715980092239 3641 378741 YLR208W SEC13
SGTC_2818 7996756 12.99 µM -0.659762808500003 0.245808678655648 no 2563 0.254703026794918 3605 2241621
SGTC_2068 5226020 147 µM -0.659828590346267 0.24578902013645 no 2564 0.254681916935721 3631 1810509
SGTC_804 1595-0054 20.9 µM -0.659993115554659 0.245739856437699 no 2565 0.254629123645674 3600 761523 Stimulates phospholipase C.
SGTC_2161 5662504 8.5105 µM -0.66001956693796 0.245731952683674 no 2566 0.254620636389734 3577 2859334
SGTC_2339 9000433 200 µM -0.660183274593002 0.245683039373477 no 2567 0.254568112045111 3567 2988954
SGTC_3115 9123671 49.47 µM -0.661908798621809 0.245167797663506 no 2568 0.254014836288009 3691 3286988
SGTC_3 0833-0587 95.581 µM -0.663589017936458 0.2446666428635 no 2569 0.253476694026701 3559 5382644
SGTC_2870 9038528 12.99 µM -0.663999567929465 0.244544273061782 no 2570 0.25334529381222 3615 6463316
SGTC_1457 k015-0032 57.3 µM -0.665181605912395 0.244192135340958 no 2571 0.252967171983427 3621 4302660
SGTC_2909 7941780 10.49 µM -0.66572139488801 0.244031419253903 no 2572 0.252794597852679 3626 1243215
SGTC_2121 5257820 149.641 µM -0.668746718053633 0.243131720321103 no 2573 0.251828530255122 3656 791256
SGTC_2669 eugenol 100 µM -0.668875889338626 0.243093346120509 no 2574 0.251787325795214 3600 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1730 st033808 45.1 µM -0.670729260129292 0.242543107610529 no 2575 0.251196509605992 3618 1045166
SGTC_1487 3970-0795 2.82 µM -0.671348261121156 0.242359485699441 no 2576 0.250999348375296 3664 3765103
SGTC_3275 9138069 49.47 µM -0.676756884580784 0.240758268049061 no 2577 0.249280108976508 3660 17617007
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.677278446680108 0.240604165020543 no 2578 0.249114651644903 3609 756377
SGTC_3294 9122953 26.2835 µM -0.677585572124358 0.240513445514374 no 2579 0.249017248287695 3641 16459826
SGTC_2907 7721985 69.9 µM -0.678597504876419 0.240214670039099 no 2580 0.248696462114657 3604 3267881
SGTC_912 3474-0017 2.18 µM -0.678742134358473 0.240171984377736 no 2581 0.248650632051335 3674 3360550
SGTC_1298 1079-1278 263 µM -0.679725638080503 0.239881824691874 no 2582 0.248339099593506 3674 2840950
SGTC_3288 9119690 36.221 µM -0.68058636112048 0.239628045538635 no 2583 0.248066629696448 3627 17595618 YKL019W RAM2
SGTC_644 1498-1197 63.3 µM -0.681914464578361 0.23923674967885 no 2584 0.247646519269956 3672 6741615
SGTC_1807 st050092 58.9 µM -0.683023405943761 0.238910292647892 no 2585 0.247296026306697 3616 5008496
SGTC_734 2023-0417 80 µM -0.683639505710142 0.238729026703845 no 2586 0.247101415942378 3622 3935732
SGTC_541 4513-1321 94 µM -0.684680006983856 0.238423066288306 no 2587 0.246772933947383 3631 747515
SGTC_1294 1000-1494 117 µM -0.685569129635205 0.238161789126431 no 2588 0.246492426912685 3634 712797 YDL207W GLE1
SGTC_1833 st055984 71 µM -0.687073595573431 0.237720045029807 no 2589 0.246018176173995 3675 676288
SGTC_3084 9116877 49.47 µM -0.687266845525727 0.237663335212146 no 2590 0.245957293754756 3580 27241325
SGTC_3080 9117754 49.47 µM -0.687521999542192 0.237588470819809 no 2591 0.245876921159081 3703 9550191
SGTC_454 lyso-paf C-16 6.67 µM -0.688676710559913 0.237249830493439 no 2592 0.245513367658885 3604 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2368 9071271 200 µM -0.689112215648723 0.237122179468018 no 2593 0.245376326658601 3649 27209959
SGTC_2635 hydroquinidine 100 µM -0.690197235429732 0.236804313188197 no 2594 0.245035080831552 3647 442912 An experimental heart treatment.
SGTC_1634 st006576 41 µM -0.690259804728856 0.236785990099041 no 2595 0.245015410165557 3644 3915356
SGTC_1140 3229-1848 2.98 µM -0.693834276495628 0.235740520469089 no 2596 0.243893072126994 3668 2849525
SGTC_617 3770-0098 35 µM -0.69678414553806 0.234879656712426 no 2597 0.242968944777751 3629 5962639
SGTC_279 1273-0055 2.93 µM -0.697512820834116 0.234667274448706 no 2598 0.24274095935894 3711 2847562
SGTC_2874 9043904 71.43 µM -0.697701834604061 0.234612201181305 no 2599 0.242681840300903 3646 4463428
SGTC_52 0329-0193 875 nM -0.698072083044962 0.234504341974021 no 2600 0.242566057896848 3734 3739292
SGTC_2327 6189656 200 µM -0.700443142602737 0.233814265684314 no 2601 0.241825300666278 3726 5349088
SGTC_3274 9138298 49.47 µM -0.70307225035615 0.233050404293425 no 2602 0.241005362280049 3651 17015756
SGTC_3145 9085516 49.47 µM -0.703282859172418 0.232989273980868 no 2603 0.240939745294365 3699 25236195
SGTC_2112 5488546 200 µM -0.704648739643466 0.232593036251308 no 2604 0.24051442945787 3668 600757
SGTC_1329 1447-1697 50.6 µM -0.705117131012616 0.232457243666298 no 2605 0.240368673210013 3676 2840515
SGTC_2438 5259590 200 µM -0.706369205049777 0.232094468103997 no 2606 0.239979283211046 3712 1201127
SGTC_71 0417-1750 47.813 µM -0.706972908951494 0.23191966378793 no 2607 0.239791656705044 3655 6811472
SGTC_1355 1499-0035 1.68 µM -0.707087084580313 0.231886612131014 no 2608 0.239756180803901 3695 1548538
SGTC_3073 9114972 49.47 µM -0.707354987307116 0.231809069725262 no 2609 0.239672951073263 3617 41905075
SGTC_3229 9132204 49.47 µM -0.708952214119916 0.2313470644801 no 2610 0.23917706569137 3687 17682924
SGTC_643 k048-0106 28.4 µM -0.712172568425289 0.23041712551638 no 2611 0.238178960710411 3714 6763920
SGTC_2365 9042475 200 µM -0.712586274364959 0.230297811666536 no 2612 0.23805090381327 3736 6464479
SGTC_647 0140-0236 81 µM -0.713746212187139 0.229963466941515 no 2613 0.237692062568675 3700 990837
SGTC_2144 5628481 200 µM -0.715072802920319 0.229581418824158 no 2614 0.23728202920536 3690 2818399
SGTC_2492 derrusnin 100 µM -0.715877293032978 0.229349905061449 no 2615 0.23703356026287 3638 1715307 Part of coumarin class of compounds.
SGTC_5 0352-0601 109.883 µM -0.715894048349771 0.229345084658046 no 2616 0.237028386858546 3622 762456
SGTC_2312 7706453 155.7 µM -0.716221822499292 0.229250797439153 no 2617 0.236927195153874 3745 976098
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.719639522781644 0.228268960668848 no 2618 0.235873485545348 3726 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2334 9017922 200 µM -0.719658014829838 0.228263654711159 no 2619 0.23586779130554 3746 3163164
SGTC_553 k007-0256 45.7 µM -0.722774269533962 0.227370492791886 no 2620 0.234909288916321 3756 6287000
SGTC_384 k007-0144 5.16 µM -0.723146179573986 0.227264029872763 no 2621 0.23479504020868 3714 6824886
SGTC_1381 2324-0066 62.1 µM -0.723589219509659 0.227137241991547 no 2622 0.234658980889272 3736 10885928
SGTC_516 3992-2719 87.3 µM -0.723753620243936 0.227090204412226 no 2623 0.234608503865734 3688 5350887 YDR037W KRS1
SGTC_2905 7799065 20.05 µM -0.724355073794343 0.226918166103229 no 2624 0.234423886863598 3642 1296806
SGTC_1431 4049-0260 9.09 µM -0.724553777638352 0.226861345498101 no 2625 0.234362912113009 3687 3854841
SGTC_2639 lactacystin 53 µM -0.724846929156046 0.226777531647623 no 2626 0.234272970945289 3738 3870 A proteasome inhibitor.
SGTC_451 chloral hydrate 100 µM -0.724979401363926 0.22673966274777 no 2627 0.234232333709277 3791 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1062 mesoridazine 14.2 µM -0.72570711627768 0.226531699646464 no 2628 0.234009169156473 3715 4078 A neuroleptic.
SGTC_2921 7974240 10.71 µM -0.725794702326411 0.226506676961043 no 2629 0.233982317540626 3740 2979074 YDR527W RBA50
SGTC_2061 5245884 80.95 µM -0.726169597659051 0.226399589778254 no 2630 0.233867403623995 3701 573863
SGTC_2370 9071495 200 µM -0.726846408637616 0.226206334158179 no 2631 0.233660024932812 3677 21791103
SGTC_3164 9100705 49.47 µM -0.727525340586742 0.226012566601118 no 2632 0.233452098836585 3701 17174235
SGTC_1961 st076550 68.7 µM -0.728821138877999 0.22564300560582 no 2633 0.233055539561487 3706 1579337
SGTC_3110 9122132 49.47 µM -0.729308834955966 0.225504003548435 no 2634 0.232906384565713 3840 918317
SGTC_820 1582-0060 59.9 µM -0.730411305255596 0.225189958589797 no 2635 0.232569405014368 3733 3848840
SGTC_1925 st057770 10.1 µM -0.731089314678681 0.224996946828663 no 2636 0.23236230027837 3707 5989122
SGTC_299 1273-0059 1.44 µM -0.731617967598174 0.224846518077193 no 2637 0.232200889183184 3673 2848077
SGTC_3158 9100007 49.47 µM -0.731896710795164 0.224767224367668 no 2638 0.232115806971902 3737 19297233
SGTC_2069 5228469 200 µM -0.733923057412108 0.224191269068158 no 2639 0.231497816714228 3700 2835210
SGTC_564 3555-0129 330 µM -0.734587535359808 0.224002584902443 no 2640 0.231295365745097 3632 563260
SGTC_417 st075190 100 µM -0.734886930630568 0.22391759856051 no 2641 0.231204179255982 3720 222757
SGTC_1408 3909-7976 48.8 µM -0.735937206853615 0.223619612069805 no 2642 0.230884456424648 3778 24152374
SGTC_2432 5630864 12.22 µM -0.736602628022716 0.223430934189933 no 2643 0.230682018166937 3727 5714970
SGTC_1781 st038725 66.3 µM -0.738385848542117 0.22292575498879 no 2644 0.230140005799306 3752 4270275 YIL048W NEO1
SGTC_880 0833-0487 87.2 µM -0.738456003282965 0.222905893744355 no 2645 0.230118696743861 3718 76075
SGTC_425 3825-7017 13.1 µM -0.738631787058732 0.222856132689272 no 2646 0.230065308390697 3828 3397440
SGTC_1581 himbacine 57.9 µM -0.738725664362175 0.222829560396805 no 2647 0.230036799186658 3742 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_440 fluspirilene 35.1 µM -0.738923084157749 0.222773685937525 no 2648 0.229976852048598 3834 3396 An atypical antipsychotic.
SGTC_342 k048-0088 23.3 µM -0.738979719619731 0.222757658239637 no 2649 0.229959656127584 3731 6820570
SGTC_791 1348-1292 225 µM -0.738995832612426 0.222753098422003 no 2650 0.229954763957689 3728 5437054
SGTC_2345 9052315 157.45 µM -0.740648217389875 0.222285772375787 no 2651 0.229453382128934 3761 6469265
SGTC_360 0957-0399 1.01 µM -0.7407262195116 0.222263725717526 no 2652 0.229429729158264 3753 6752301 YPR165W RHO1
SGTC_972 1319-0219 195 µM -0.740937818138589 0.222203925388936 no 2653 0.229365571938026 3711 23903702
SGTC_2165 5727197 32.143 µM -0.741909633707087 0.221929396514622 no 2654 0.229071044278048 3830 1361712
SGTC_2824 7998404 51.95 µM -0.74318534579343 0.221569313871826 no 2655 0.228684737100443 3733 837851
SGTC_27 0485-0001 32.618 µM -0.743873338936784 0.221375259530933 no 2656 0.228476553082897 3677 2054479
SGTC_1526 st051518 75 µM -0.74635695979619 0.220675542266598 no 2657 0.227725905815241 3754 673993
SGTC_300 r073-0011 5.04 µM -0.747720977883716 0.220291793298258 no 2658 0.227314237518114 3766 2735780
SGTC_3044 9093193 49.47 µM -0.748087072955728 0.220188862314947 no 2659 0.227203819391802 3733 25236277
SGTC_1883 5-benzylidenerhodanine 20 µM -0.749146522941306 0.219891143696931 no 2660 0.22688444851136 3767 1273210
SGTC_545 4218-0007 221 µM -0.750646950224892 0.219469900502877 no 2661 0.226432578718145 3706 2840508
SGTC_3153 9100258 49.47 µM -0.753880539073024 0.218563652103764 no 2662 0.225460478596649 3706 25236848
SGTC_562 3772-2733 112 µM -0.755171632329276 0.218202411929291 no 2663 0.225073003626405 3789 2876874 YIL048W NEO1
SGTC_1213 1315-0166 115 µM -0.756388931600896 0.21786213420789 no 2664 0.224708021094342 3820 768401
SGTC_111 0083-0039 52.457 µM -0.756998314974875 0.21769190525625 no 2665 0.2245254359837 3672 759313
SGTC_2911 7942208 15.64 µM -0.757299798132896 0.217607715454293 no 2666 0.224435135910393 3764 1243384
SGTC_951 1171-0579 82.7 µM -0.757826155192779 0.21746077419293 no 2667 0.22427753114195 3744 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2168 5727979 200 µM -0.759991068925627 0.216857005417169 no 2668 0.223629961698342 3708 695210
SGTC_205 1486-1330 71.903 µM -0.760432525755928 0.216734007406869 no 2669 0.223498043672859 3756 4118834
SGTC_1172 0370-0043 85 µM -0.760501721783325 0.216714731776228 no 2670 0.223477370232604 3802 376585
SGTC_1373 2887-0003 58.5 µM -0.76068340396439 0.21666412609556 no 2671 0.223423094899907 3776 776948
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.762044454126255 0.216285237192138 no 2672 0.22301673639917 3843 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2210 7115885 190.385 µM -0.764328474825777 0.215650274626189 no 2673 0.222335760292535 3808 2927039
SGTC_1994 st072947 40.9 µM -0.764943360647133 0.215479519903117 no 2674 0.222152636202413 3831 5286565 YDL195W SEC31
SGTC_2120 5538279 151.968 µM -0.765099331989061 0.215436218898329 no 2675 0.222106198813932 3775 2058197
SGTC_283 0987-0079 11.7 µM -0.765780006008221 0.215247308217571 no 2676 0.221903606424367 3805 411556
SGTC_2982 9019404 25.97 µM -0.767057185604085 0.214893106069151 no 2677 0.221523758037268 3710 22333232
SGTC_235 0330-0087 5 mM -0.767381453609593 0.214803230253012 no 2678 0.221427376074666 3821 46494818 YHR062C RPP1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.769410482824249 0.214241349967941 no 2679 0.220824833724984 3760 7104
SGTC_1559 coumarin 343 70.1 µM -0.769906495162743 0.214104124032912 no 2680 0.220677680385302 3786 108770 A hepatotoxic, DNA x-linker.
SGTC_2273 7815444 169.05 µM -0.769998267481911 0.214078740066863 no 2681 0.22065046019877 3720 2824616
SGTC_1710 st031758 61.5 µM -0.771048562297215 0.213788356215546 no 2682 0.220339073837015 3827 5394341
SGTC_1658 st012944 20 µM -0.772335977695471 0.213432726750506 no 2683 0.21995773097172 3718 24207260
SGTC_1078 idebenone 36.1 µM -0.772343218943638 0.213430727438464 no 2684 0.219955587126969 3849 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1716 st033144 30.6155 µM -0.775693922516963 0.212506768370109 no 2685 0.218964864572421 3784 674617
SGTC_2100 5377183 190 µM -0.776309221755621 0.212337353422156 no 2686 0.218783214718056 3816 2844202
SGTC_2721 ifenprodil 61.44 µM -0.776975690768362 0.212153938593833 no 2687 0.218586556290604 3779 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2706 st078239 82.5 µM -0.778603168219621 0.211706440009954 no 2688 0.21810675610174 3790 15434492
SGTC_3050 9093513 49.47 µM -0.779548221665685 0.211446837557684 no 2689 0.217828421646906 3798 25236664
SGTC_2208 7283366 200 µM -0.780748643915811 0.211117355237008 no 2690 0.217475172253744 3776 898663
SGTC_143 4032-1194 15.74 µM -0.780823387202919 0.211096850251467 no 2691 0.217453188417452 3825 1806963
SGTC_1376 2910-0861 41.3 µM -0.781230660081828 0.210985139998923 no 2692 0.21733342200496 3777 1112859
SGTC_994 3910-0338 138 µM -0.781641976161286 0.210872355925306 no 2693 0.21721250528146 3890 3479481
SGTC_2253 7938677 135.83 µM -0.782475836300604 0.210643817551932 no 2694 0.21696749036829 3849 2301972
SGTC_962 1254-0300 21.5 µM -0.784256578301728 0.210156251449401 no 2695 0.216444786273625 3762 7340576
SGTC_2944 9067346 25.62 µM -0.784400584424003 0.210116851651086 no 2696 0.216402547795093 3740 6473075
SGTC_2491 paeonol 100 µM -0.786437457688147 0.20956003194334 no 2697 0.215805623033108 3698 11092 Increases levels of cortical cytochrome oxidase.
SGTC_356 1634-0012 32.5 µM -0.786668618507743 0.209496894435806 no 2698 0.215737939542977 3773 735457
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.787371297683843 0.209305038716855 no 2699 0.215532271860286 3842 688798
SGTC_966 1300-0360 30.2 µM -0.787681788191468 0.209220297021766 no 2700 0.215441430402313 3808 70588
SGTC_663 1486-0733 13.9 µM -0.788464225960432 0.209006837088451 no 2701 0.215212607965965 3831 722445 YPR165W RHO1
SGTC_1108 betulinic acid 729.144 nM -0.789669585651643 0.208678249281102 no 2702 0.214860378993759 3828 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1618 st003135 44.5 µM -0.79362893041972 0.207601054629308 no 2703 0.213705742583546 3737 1270615
SGTC_2675 theaflavin digallate 100 µM -0.793913231490423 0.207523833221041 no 2704 0.213622973137365 3791 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_3064 1327-0027 10 µM -0.794413639381639 0.207387954462913 no 2705 0.213477333223754 3699 16000455 YPR107C YTH1
SGTC_2182 6325192 200 µM -0.79464066631273 0.207326325825898 no 2706 0.213411277847967 3742 736248
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.795145757645975 0.207189252792139 no 2707 0.213264360065923 3874 5379071
SGTC_917 harmaline 728.087 nM -0.796195228323161 0.206904616086752 no 2708 0.212959285299515 3849 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_365 0121-0052 13.6 µM -0.797018553228442 0.206681476566537 no 2709 0.212720128095842 3871 3101739
SGTC_930 2810-3379 265 µM -0.797284876805161 0.206609327416523 no 2710 0.212642800718672 3842 1015764
SGTC_2302 7771753 200 µM -0.797893518246649 0.206444497674767 no 2711 0.212466142565794 3843 2203047
SGTC_1954 st077032 68.9 µM -0.800133598684485 0.205838519820073 no 2712 0.211816698241319 3735 698907
SGTC_3023 9089636 49.47 µM -0.801283381372187 0.205527895363332 no 2713 0.211483804734227 3911 17249241
SGTC_629 3448-6466 76.7 µM -0.802803308058565 0.205117700482193 no 2714 0.211044214921154 3837 573744
SGTC_2636 apigenin dimethyl ether 100 µM -0.803136409683303 0.205027868698227 no 2715 0.210947947612147 3849 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3208 9114115 49.47 µM -0.80485120977015 0.204565786780866 no 2716 0.210452773131903 3869 650895
SGTC_574 1315-0397 40 µM -0.806851131685559 0.204027657507888 no 2717 0.209876128164019 3852 6794277
SGTC_1312 1218-2183 165 µM -0.80810731791499 0.203690080679933 no 2718 0.209514402640267 3831 6744073
SGTC_3252 9135871 49.47 µM -0.810057427175746 0.203166685137076 no 2719 0.208953585471275 3844 17682838
SGTC_3063 1327-0034 4 µM -0.811017664924358 0.202909259368545 no 2720 0.208677763174679 3731 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1060 3448-7350 82 µM -0.811066253194731 0.202896238740785 no 2721 0.208663812204001 3775 570178
SGTC_758 0868-0029 16 µM -0.811222295062017 0.20285442619923 no 2722 0.208619012196762 3920 762687
SGTC_3066 9117245 49.47 µM -0.811448767346786 0.202793750477738 no 2723 0.208554001529487 3915 17176980
SGTC_3221 9128209 49.47 µM -0.812243224283006 0.202580987897133 no 2724 0.208326040821774 3891 16460723
SGTC_2063 5246145 200 µM -0.814744901302521 0.201911888842963 no 2725 0.207609172854724 3901 711240
SGTC_2425 5628681 7.85 µM -0.815032577689037 0.201835031762498 no 2726 0.207526831305824 3930 5714958
SGTC_3087 9117406 49.47 µM -0.815390704804356 0.201739377189158 no 2727 0.20742435163463 3824 42546093
SGTC_548 1436-0017 110 µM -0.816386412297674 0.201473569709409 no 2728 0.207139582751174 3922 9677137
SGTC_1205 4161-2785 76 µM -0.816524065290095 0.201436839297376 no 2729 0.207100232677043 3961 3498106
SGTC_485 niflumic acid 177 µM -0.816771489893708 0.201370828246469 no 2730 0.207029513939028 3911 4488 A COX2 inhibitor.
SGTC_64 000l-0018 272.079 µM -0.82020807176764 0.20045531502063 no 2731 0.206048750626534 3794 6811119
SGTC_885 0865-0106 16.8 µM -0.820943912229027 0.200259610897751 no 2732 0.205839108417549 3793 2793380
SGTC_350 k064-0020 19.8 µM -0.821429767416898 0.200130455807602 no 2733 0.205700756832524 3824 2790705
SGTC_2654 protoveratrine a 100 µM -0.821444895087126 0.200126435216504 no 2734 0.205696449980043 3842 5702278 A heart drug and vasodilator.
SGTC_1680 diphenhydramine 100 µM -0.824813323466405 0.19923239290053 no 2735 0.20473879065191 3887 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_818 4072-2707 53.5 µM -0.825654595813494 0.199009479860347 no 2736 0.20450002766864 3782 882871
SGTC_2934 9036370 36.88 µM -0.826420149444455 0.198806760771926 no 2737 0.204282898622115 3890 6462800
SGTC_960 1222-0186 7.7 µM -0.82644046155445 0.19880138380814 no 2738 0.204277139499142 3940 3126296
SGTC_1263 0774-1208 64.8 µM -0.82705618325181 0.198638433329511 no 2739 0.204102608889628 3865 906585
SGTC_2163 5671233 125 µM -0.831012343688472 0.197593359981107 no 2740 0.202983328100942 3863 701023
SGTC_216 k038-0035 28.382 µM -0.831532109402088 0.197456304277664 no 2741 0.202836548394767 3786 4444231 YPR107C YTH1
SGTC_645 0845-0943 5.41 µM -0.83404952728678 0.196793306565262 no 2742 0.202126537639222 3881 1885106
SGTC_3113 9123498 49.47 µM -0.83500156739213 0.196542925019664 no 2743 0.201858412938868 3926 8897275
SGTC_369 0957-0393 4.5 µM -0.835404248861393 0.196437080020733 no 2744 0.201745069174137 3906 6997992
SGTC_865 0488-0499 301 µM -0.835981423387534 0.196285429702843 no 2745 0.201582676892968 3841 9634651
SGTC_127 0180-0333 59.125 µM -0.836270315987759 0.196209550978948 no 2746 0.201501424260175 3796 771601
SGTC_918 glabranin 770.725 nM -0.837118832836088 0.195986787708524 no 2747 0.201262887723201 3919 124049 Also referred to as licorice root.
SGTC_2052 5265182 7.135 µM -0.837411318796042 0.195910036203867 no 2748 0.201180702811645 3904 1239884
SGTC_254 nsc-64875 3.808 µM -0.838562222404576 0.195608203661298 no 2749 0.200857508671455 3919 56993
SGTC_579 4491-1009 110 µM -0.839593216643439 0.195338058086682 no 2750 0.200568251939371 4017 1271041
SGTC_2734 clemastine 41.6 µM -0.840178066817947 0.195184913918776 no 2751 0.200404277063615 3890 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1510 1123-0200 71.5 µM -0.840629105038447 0.195066858523554 no 2752 0.200277874160047 3944 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1434 4073-0095 163 µM -0.847500624773503 0.193273669534007 no 2753 0.198358069487152 3849 24133745
SGTC_2027 5150920 200 µM -0.848046596723839 0.193131625638939 no 2754 0.198206010424238 3871 786715
SGTC_2225 6654152 15.4 µM -0.849237727314742 0.192821954007711 no 2755 0.197874512051067 3788 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2018 5133068 143 µM -0.84981908164932 0.192670922990823 no 2756 0.19771283955674 3892 785362
SGTC_492 tmb-8 126 µM -0.850187372193299 0.192575281588859 no 2757 0.197610460632783 3837 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1439 4092-1168 46 µM -0.851186625347612 0.192315931670053 no 2758 0.197332845587567 3908 2886240
SGTC_146 3448-8650 53.125 µM -0.85135668707956 0.192271814489245 no 2759 0.197285622106442 3879 2891488 YIL048W NEO1
SGTC_2961 9083290 32.55 µM -0.85242971650433 0.191993593440857 no 2760 0.196987816303779 3842 17741490
SGTC_477 mead ethanolamide 10 µM -0.852617693354989 0.191944879130236 no 2761 0.196935673720459 3758 16061185
SGTC_450 aminopyrene 156 nM -0.85306856848991 0.191828065414746 no 2762 0.196810640283154 3818 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_806 3966-4455 5.86 µM -0.853221958032974 0.191788334840886 no 2763 0.196768114363457 3894 714982
SGTC_459 nigericin 15.3 µM -0.8532595585972 0.191778596406219 no 2764 0.196757690782624 3943 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3226 9131256 49.47 µM -0.858681349902149 0.190377539533602 no 2765 0.195258171332759 3812 17178073
SGTC_1891 st059073 26.2 µM -0.859536236396682 0.190157201607908 no 2766 0.195022368452049 3991 688754
SGTC_2013 4024628 200 µM -0.85968439756682 0.190119030575965 no 2767 0.194981518845621 3948 5230760
SGTC_1391 3442-0225 151 µM -0.860482501272165 0.189913494671371 no 2768 0.194761562689643 3869 5227075
SGTC_1216 1165-0504 9.65 µM -0.86073474113656 0.189848563678255 no 2769 0.194692077172508 3920 6304004
SGTC_203 k066-0004 30.888 µM -0.861463685644774 0.189660997231325 no 2770 0.194491356722884 3982 6795412
SGTC_1649 st011737 51.3 µM -0.862215823866978 0.1894675822879 no 2771 0.19428438178923 3904 1761035
SGTC_297 0986-0032 24 µM -0.865125944094299 0.188720378814273 no 2772 0.193484833160968 3888 2847425
SGTC_2490 carminic acid 95.39 µM -0.865701122450656 0.188572911077721 no 2773 0.193327042164652 3825 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2989 9073649 71.4286 µM -0.866935430518463 0.188256691557911 no 2774 0.192988694623343 3838 21367202
SGTC_1388 3346-4487 254 µM -0.867342049748559 0.188152590758887 no 2775 0.192877311718008 3990 3345614
SGTC_3347 9188721 44.724 µM -0.867361449837584 0.188147624924716 no 2776 0.192871998542966 3973 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1780 st038448 24.544 µM -0.867835182864096 0.188026388747138 no 2777 0.192742283252808 3991 728868 YDL195W SEC31
SGTC_660 4031-1742 102 µM -0.868690797713391 0.187807544882491 no 2778 0.192508138042067 3854 6738706
SGTC_1608 st001473 40.5 µM -0.870231868739539 0.187413776305216 no 2779 0.192086851652417 3900 7292267
SGTC_3002 9075603 71.4286 µM -0.87087739294016 0.187248986190702 no 2780 0.191910550878209 3879 20105405
SGTC_3129 9127257 49.47 µM -0.872308297386039 0.186884022900882 no 2781 0.191520106154999 3931 837894
SGTC_280 3448-3607 3.04 µM -0.87292822892471 0.186726041308952 no 2782 0.191351099313419 3911 626179
SGTC_1923 st058458 19.1 µM -0.874895719750472 0.186225199304187 no 2783 0.190815324109927 3974 3534982
SGTC_3184 9108758 49.47 µM -0.87729138704187 0.185616486359645 no 2784 0.190164194612222 3953 902885
SGTC_2876 9059903 25.97 µM -0.877883713745276 0.185466173177635 no 2785 0.190003414148411 3880 6916095
SGTC_2094 5332512 191.667 µM -0.877958564277025 0.185447183934498 no 2786 0.189983102756254 3987 755774
SGTC_200 k038-0079 37.545 µM -0.878135737614153 0.185402240665388 no 2787 0.189935030432296 3901 3436683
SGTC_2764 methyldopa 94.69 µM -0.879841475621765 0.184969894889568 no 2788 0.189472596314382 3923 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2687 chenodiol 100 µM -0.880176287718562 0.184885105174289 no 2789 0.189381908488943 4017 5702181 A cholesterol synthesis inhibitor.
SGTC_3015 9080845 49.47 µM -0.880917267155985 0.184697541236997 no 2790 0.189181300435164 4011 5296973
SGTC_487 nimodipine 119 µM -0.881440273189145 0.184565224097567 no 2791 0.189039783916291 3846 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1375 2910-0797 186 µM -0.883201790651679 0.184120005376778 no 2792 0.188563627146813 3969 742508
SGTC_2232 chlorophetanol 41.5365 µM -0.883377649972781 0.18407559414668 no 2793 0.188516131148332 4008 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1859 st055998 20 µM -0.883395862452208 0.184070995177534 no 2794 0.188511212752493 3890 676301
SGTC_2346 9031566 143.75 µM -0.884614786365761 0.183763358215417 no 2795 0.188182214494169 3920 4771086
SGTC_2009 4012297 12.05 µM -0.88515342357877 0.183627516870281 no 2796 0.188036944535604 3970 45595307
SGTC_945 3381-0768 11.3 µM -0.885390260087489 0.183567807814567 no 2797 0.187973091864492 4008 1126236 YIL048W NEO1
SGTC_1768 st044301 37.178 µM -0.886588448276322 0.183265917048665 no 2798 0.187650257709848 3960 3931349
SGTC_3022 9087993 49.47 µM -0.887466650113453 0.183044845523929 no 2799 0.187413856838014 4003 17173644
SGTC_2606 farnesol 9.78 µM -0.888314846299042 0.182831485403828 no 2800 0.187185707950775 4006 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2355 9061122 103.12 µM -0.888938706805352 0.182674655082351 no 2801 0.187018010832448 3979 5302957
SGTC_1209 2323-2347 50.3 µM -0.889540796860697 0.182523377243122 no 2802 0.186856253894866 3944 5412760
SGTC_2123 5259487 200 µM -0.889709985008992 0.182480882045595 no 2803 0.186810815556885 3977 2173474
SGTC_2540 epiandrosterone 100 µM -0.890141390007075 0.18237255348881 no 2804 0.186694985403849 4001 441302 A steroid.
SGTC_833 3852-0053 558 µM -0.890311667758046 0.182329806717055 no 2805 0.18664927889272 4017 3123681
SGTC_2763 lisinopril 49.32 µM -0.891460898345185 0.182041465957455 no 2806 0.186340979855027 3856 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2092 5303694 80.6725 µM -0.891530110012477 0.182024109928785 no 2807 0.186322422823029 3956 1963699
SGTC_2481 5478948 45.16 µM -0.894541089831433 0.181270056185082 no 2808 0.185516227600331 4018 77792
SGTC_3095 9117207 49.47 µM -0.898365458159462 0.180315126562994 no 2809 0.184495372692135 3944 17015229
SGTC_2275 7947463 200 µM -0.898546740982155 0.180269939461535 no 2810 0.184447068992576 3934 1225414
SGTC_2198 6589944 200 µM -0.899382804956955 0.1800616316176 no 2811 0.184224397453941 3965 5290268
SGTC_1642 st009582 77.7 µM -0.901498376274374 0.179535206044157 no 2812 0.18366169837795 3924 6739311
SGTC_1733 st037357 54.9 µM -0.901835601925025 0.179451382391988 no 2813 0.183572102252252 3890 1272339 YGL099W LSG1
SGTC_2320 7373003 200 µM -0.903489679749814 0.179040587236603 no 2814 0.183133031550888 4060 5415828
SGTC_2834 9001755 58.44 µM -0.903670745362914 0.178995655008706 no 2815 0.183085007961529 3906 2989575
SGTC_1232 0279-0259 161 µM -0.904790099073059 0.178718040004686 no 2816 0.182788298955073 3991 1560000
SGTC_1495 4469-0029 237 µM -0.904854000497482 0.178702199762812 no 2817 0.182771369556885 3984 793680
SGTC_1286 0929-0070 131 µM -0.905092910877119 0.17864298515488 no 2818 0.182708083724341 4071 1420408
SGTC_1847 st056231 15 µM -0.905463316619458 0.178551203483285 no 2819 0.182609992663463 3957 5393180
SGTC_1610 st001799 48.1 µM -0.913165133308361 0.176649527315272 no 2820 0.180577849272513 3888 621897
SGTC_1087 pterostilbene 9.05 µM -0.915087431226595 0.176176892065036 no 2821 0.18007286635938 4048 5281727 Similar to reservatol, lowers cholesterol.
SGTC_426 0988-0037 14.6 µM -0.915462230414729 0.176084833542013 no 2822 0.179974510920743 4020 5383008
SGTC_2703 st077852 53.4 µM -0.917483122626944 0.175588985040105 no 2823 0.179444766461318 4041 6281836
SGTC_1268 0828-0275 2.46 µM -0.917730993034298 0.175528228242548 no 2824 0.179379858767292 4040 745337
SGTC_1686 st019653 115.5 µM -0.9182202613524 0.175408340266841 no 2825 0.179251781608428 3940 97252
SGTC_621 3584-0052 32.1 µM -0.919101530963057 0.17519252915644 no 2826 0.179021234285298 3977 2273927
SGTC_726 3448-4391 34.2 µM -0.919204903869649 0.175167225557576 no 2827 0.178994203320569 4106 1356692
SGTC_2883 9059145 45.46 µM -0.920953220014406 0.174739624258468 no 2828 0.178537425497896 3975 16476510
SGTC_284 0988-0104 32.6 µM -0.921023817549572 0.174722371518992 no 2829 0.178518996106068 3977 4666532
SGTC_2732 terfenadine 20 µM -0.922983817276803 0.174243815454036 no 2830 0.178007819297086 4004 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1509 1326-1131 80 µM -0.925069025367129 0.17373560372098 no 2831 0.177465001910126 3904 768313
SGTC_1466 k213-0079 57.5 µM -0.925104051224043 0.173727075198485 no 2832 0.177455892978106 3929 3657981
SGTC_650 1328-0195 38 µM -0.92523522462322 0.173695137867082 no 2833 0.177421782243144 3968 2780821
SGTC_1048 3161-0300 24.5 µM -0.925872385730635 0.173540058751238 no 2834 0.177256151796648 3994 2165101
SGTC_3243 9134147 49.47 µM -0.928141691528344 0.172988446768604 no 2835 0.176667037828351 4055 24282180
SGTC_1516 st013856 110 µM -0.928260225650588 0.172959664793209 no 2836 0.176636300315442 4055 5281404 A mutagen and neurotoxin.
SGTC_1611 st001856 99.4 µM -0.929973897369132 0.172543898925821 no 2837 0.176192299790628 3982 647478
SGTC_3039 9090270 49.47 µM -0.934229797907623 0.171514104654191 no 2838 0.175092684016373 4012 17173750
SGTC_2569 tetrandrine 100 µM -0.938147916198823 0.170569522893282 no 2839 0.174084200119856 4031 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_223 busulfan 5 mM -0.944722331977785 0.168992058410216 no 2840 0.172400326383165 4035 2478 A DNA alkylator.
SGTC_1013 4112-3890 241 µM -0.945846057995249 0.168723372417073 no 2841 0.17211355492068 3970 705171
SGTC_2115 tiliquinol 12.7705 µM -0.945879787451475 0.168715311857206 no 2842 0.172104951975047 4011 71208 A bioactive hydroxyquinoline.
SGTC_685 1278-0033 54.9 µM -0.946275717151012 0.168620712320331 no 2843 0.172003987716496 4068 3590572
SGTC_2888 9058547 12.99 µM -0.946686711554714 0.168522549444999 no 2844 0.171899221881204 3934 16476514
SGTC_3151 9099821 49.47 µM -0.947463244191018 0.168337180862522 no 2845 0.171701388606492 4007 17174189
SGTC_3137 9097352 49.47 µM -0.947534743902261 0.168320119534177 no 2846 0.171683180303361 4038 44120435
SGTC_1748 st037455 53.6035 µM -0.947709228102787 0.168278488619138 no 2847 0.171638750879539 4070 580690
SGTC_2073 5212005 126 µM -0.952800351179386 0.167066692894383 no 2848 0.170345618172697 3819 691789
SGTC_2722 naftopidil 47.16 µM -0.955013365808419 0.166541707200951 no 2849 0.169785468930804 3942 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_108 0509-0257 621.132 µM -0.95562093892278 0.16639776127557 no 2850 0.16963188939898 4000 536624
SGTC_2366 9070441 60.58 µM -0.957193153778051 0.166025645922136 no 2851 0.16923488598548 4042 6837235
SGTC_762 1165-0429 115 µM -0.958332557422929 0.165756305613166 no 2852 0.168947545778324 4049 5967793
SGTC_2788 5282734 71.43 µM -0.958709553117431 0.165667250930751 no 2853 0.168852542259936 4138 743706
SGTC_2642 cholecalciferol 100 µM -0.958929011640335 0.165615424246071 no 2854 0.168797254170112 4043 9821465 A vitamin D precursor, similar to steriods.
SGTC_2078 5212016 200 µM -0.959702476543214 0.16543284863769 no 2855 0.168602488253288 3891 1899708
SGTC_2272 7805186 180 µM -0.962635655116577 0.164741658486042 no 2856 0.167865198915106 4061 2956062 YPR165W RHO1
SGTC_2553 4-methylesculetin 85.09 µM -0.963644700103333 0.164504314752341 no 2857 0.167612044011722 4079 5319502
SGTC_3289 9119912 71.43 µM -0.964318055754979 0.164346053945647 no 2858 0.167443245618355 4107 17014829
SGTC_2353 9059630 146.67 µM -0.965929473927899 0.163967718398095 no 2859 0.167039736356334 4086 4779114
SGTC_2745 rifampicin 24.3 µM -0.967143330403027 0.163683097529814 no 2860 0.166736193473684 4052 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_371 0195-0006 7.36 µM -0.970694588095996 0.16285225387902 no 2861 0.165850193820399 3891 3928593
SGTC_2992 9074591 71.4286 µM -0.971822637236638 0.162588913148407 no 2862 0.165569396027251 4010 17741321
SGTC_115 0527-0192 112.043 µM -0.971944179697297 0.162560555856193 no 2863 0.165539159628385 4061 4233931
SGTC_1138 3761-0006 1.03 µM -0.97210323436774 0.162523451383504 no 2864 0.165499596625713 4062 12061087
SGTC_3339 9145883 14.936 µM -0.973516399122372 0.162194028551972 no 2865 0.16514835690069 3985 2030670
SGTC_2401 5128683 200 µM -0.975601115151163 0.161708854729166 no 2866 0.16463108585685 4053 708373
SGTC_110 0850-0284 111.64 µM -0.976094408086376 0.161594189702471 no 2867 0.164508841101546 3862 3906265
SGTC_2564 betulinic acid 100 µM -0.976583893798455 0.161480462062096 no 2868 0.164387597995574 4135 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2160 5660466 132.927 µM -0.977923341562169 0.161169520190246 no 2869 0.164056119864391 3942 2859134
SGTC_598 3937-0236 20.2 µM -0.979700035687379 0.160757678284688 no 2870 0.163617104248544 4137 1379313
SGTC_2033 5192550 145 µM -0.980672448786834 0.16053256186024 no 2871 0.163377147271699 4058 182073
SGTC_1630 st005209 31.3 µM -0.981330679508509 0.160380296493681 no 2872 0.163214849143352 4015 3367314
SGTC_1815 st051655 58.2 µM -0.983726121529523 0.159826967279217 no 2873 0.162625096333746 4027 5984156
SGTC_1654 st012436 41.8 µM -0.986011552033515 0.159300215423014 no 2874 0.162063722060179 4010 4323132
SGTC_1875 nocodazole 6 µM -0.986116339705671 0.159276090981264 no 2875 0.162038013177879 4088 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_163 TUB2.036 7.546 µM -0.988452593232731 0.158738855042465 no 2876 0.161465520457037 4063 15992207 YJR013W GPI14
SGTC_99 0109-0120 622.8 µM -0.989948255166405 0.158395542767043 no 2877 0.16109970577278 4058 759414
SGTC_2403 6032726 181.2 µM -0.989980039168463 0.158388252398404 no 2878 0.161091937793655 4143 2881040
SGTC_3320 9137005 35.139 µM -0.99005834195982 0.158370292848734 no 2879 0.161072801710565 4092 4908713
SGTC_3052 9092717 49.47 µM -0.993108251804491 0.157671804172343 no 2880 0.160328601534116 4104 25237534
SGTC_2780 5215298 71.43 µM -0.995974793625709 0.157017158107844 no 2881 0.15963119626837 4132 2834131
SGTC_2359 9039622 200 µM -0.997879916477907 0.156583066356013 no 2882 0.159168795876389 4037 6463596
SGTC_620 0109-0052 432 µM -1.00781148276258 0.154332915802161 no 2883 0.156772486150499 4096 493037
SGTC_2806 7952793 58.44 µM -1.0092526944823 0.154008172267831 no 2884 0.156426730438108 4175 2972490
SGTC_593 1203-0218 61.7 µM -1.01198610025294 0.153393505622651 no 2885 0.155772349709463 4129 3666956
SGTC_807 1315-0151 48 µM -1.01218325018158 0.153349235027768 no 2886 0.155725221663934 4136 4011080
SGTC_3197 9113331 49.47 µM -1.01238863539493 0.153303124178731 no 2887 0.155676135001491 4139 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_886 0866-0150 153 µM -1.01399229452759 0.152943404029492 no 2888 0.155293214551389 4171 271463
SGTC_988 1497-1057 103 µM -1.01688443463838 0.152296077821354 no 2889 0.1546042044228 4058 3533044
SGTC_2318 6029776 164 µM -1.0178999297627 0.15206921915227 no 2890 0.154362757511038 4153 818325
SGTC_2815 7968870 71.43 µM -1.01805961813347 0.152033565663978 no 2891 0.154324812262601 4087 2977326 YHR190W ERG9
SGTC_3171 9103192 49.47 µM -1.0182519144832 0.15199063918847 no 2892 0.154279126872524 4162 13018434
SGTC_260 nsc-65238 3.989 µM -1.01855121030629 0.151923843148595 no 2893 0.154208038552004 4094 3246252
SGTC_3214 9129694 49.47 µM -1.01928632588243 0.151759864806413 no 2894 0.154033526906997 4161 17158655
SGTC_2106 5357045 167.29 µM -1.02037656592391 0.151516887370578 no 2895 0.153774951709186 4129 668842
SGTC_2676 harmalol 100 µM -1.02142205571809 0.151284126304733 no 2896 0.153527260084286 4057 5459187 A monoamine oxidase inhibitor
SGTC_82 0054-0107 293.755 µM -1.02231308237443 0.151085941727789 no 2897 0.153316371670648 4062 3104697
SGTC_787 4152-0075 138 µM -1.02649901009017 0.150157209231784 no 2898 0.15232821499492 4131 9566539
SGTC_395 anisomycin 6.25 µM -1.02685687699824 0.150077986194801 no 2899 0.1522439312671 4123 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1855 st056195 39.6 µM -1.03352811275846 0.148606238451056 no 2900 0.150678410689113 4076 4028379
SGTC_37 0566-0070 1.56 µM -1.0360513193955 0.148052114815001 no 2901 0.150089100634336 4090 1626686
SGTC_608 k048-0125 159 µM -1.03626848505602 0.148004487587457 no 2902 0.150038452202457 4176 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_703 3875-0075 71.8 µM -1.03650758688938 0.147952061336882 no 2903 0.149982700891297 4170 2850814
SGTC_2283 7944793 200 µM -1.03769381063596 0.147692149870529 no 2904 0.149706313697199 4157 2970533
SGTC_2028 5153890 36.43 µM -1.03771545349103 0.14768741058364 no 2905 0.149701274124001 4097 2830968 YPR165W RHO1
SGTC_1348 1493-0373 93.8 µM -1.03900901867293 0.147404334557274 no 2906 0.149400270953528 4131 3010129
SGTC_2842 9000675 19.48 µM -1.03976548922135 0.147238961678548 no 2907 0.149224433125611 4192 2989072
SGTC_212 3807-4682 38.772 µM -1.04071882630331 0.147030728770219 no 2908 0.14900303154846 4199 3125501 YBL034C STU1
SGTC_51 1013-0126 23.419 µM -1.04140817489258 0.146880280701568 no 2909 0.14884307504251 4114 1627850
SGTC_3157 9099274 49.47 µM -1.04355099759847 0.146413276238344 no 2910 0.148346587248141 4175 17217662
SGTC_1484 3473-2379 286 µM -1.04412332301506 0.146288713121668 no 2911 0.148214168240009 4251 671917
SGTC_49 0717-0965 32.132 µM -1.04470087479565 0.146163084679754 no 2912 0.148080620201302 4226 5889349 YGL099W LSG1
SGTC_692 k241-0027 77.8 µM -1.04495383038711 0.146108084877518 no 2913 0.148022154322592 4200 3600480
SGTC_1856 st057054 55.7 µM -1.04501915568301 0.146093883543183 no 2914 0.148007058132162 4153 1266018
SGTC_1675 st018485 24.5 µM -1.048190964213 0.145405466495551 no 2915 0.147275316383449 4183 3323024
SGTC_2923 7992654 58.14 µM -1.05705454283853 0.143493277875155 no 2916 0.145243347775222 4157 2985126
SGTC_2645 abamectin 100 µM -1.05910423800901 0.14305351363221 no 2917 0.14477615505333 4106 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_979 1426-2828 121 µM -1.0597317591176 0.142919060577574 no 2918 0.144633324993525 4254 747872
SGTC_2008 4012253 172 µM -1.06154899007891 0.14253018144046 no 2919 0.144220240707907 4145 603940
SGTC_3255 9139072 49.47 µM -1.06244291243212 0.14233914896868 no 2920 0.144017330675849 4175 17646060
SGTC_699 0375-0592 111 µM -1.06274584547646 0.142274451063744 no 2921 0.143948612078557 4234 762578
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.06289703971389 0.14224216770851 no 2922 0.14391432282121 4199 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1682 st012968 530 nM -1.06597065281251 0.141586957057492 no 2923 0.143218454209469 4176 24207270
SGTC_590 k048-0076 22.4 µM -1.06607521633257 0.14156470298388 no 2924 0.14319482097994 4188 6832814
SGTC_2149 5554786 194.827 µM -1.06729138590629 0.141306041788752 no 2925 0.142920138352897 4182 745063 YPR165W RHO1
SGTC_2610 ononetin 44.17 µM -1.06853073575768 0.141042780269963 no 2926 0.142640586815623 4153 259632
SGTC_3156 9099931 49.47 µM -1.06892476158158 0.140959151411349 no 2927 0.142551786658679 4189 18111053
SGTC_768 0384-0033 77.3 µM -1.07253317784995 0.140194858104767 no 2928 0.141740310074783 4137 3965305 YMR134W ERG29
SGTC_253 dyclonine 31.25 µM -1.07291724401679 0.140113675684038 no 2929 0.141654124171797 4257 3180 An oral anasthetic.
SGTC_2462 5162487 171.77 µM -1.07698795473274 0.139255187760542 no 2930 0.140742823476021 4070 2259986
SGTC_556 4058-0063 51.5 µM -1.07998108303187 0.138626243401053 no 2931 0.140075302060934 4207 6615692
SGTC_159 3970-0959 50 µM -1.08021662068563 0.138576832272583 no 2932 0.14002286437702 4245 6615653
SGTC_3263 9137018 49.47 µM -1.08062879067463 0.138490396057314 no 2933 0.139931135180947 4147 43844957
SGTC_1146 3579-1023 7 µM -1.0821125693964 0.138179536881052 no 2934 0.139601255656027 4204 X1146
SGTC_1928 4'-methoxychalcone 40.3 µM -1.08774584679682 0.137003670659097 no 2935 0.138353661012991 4219 641818
SGTC_1683 st010134 710 nM -1.08776885477953 0.136998882133845 no 2936 0.138348581097279 4163 3818134
SGTC_478 N-arachidonylglycine 10 µM -1.08817811878694 0.136913723370979 no 2937 0.138258241239421 4150 5283389
SGTC_882 0843-0131 351 µM -1.08992220606498 0.136551223127437 no 2938 0.13787370693232 4185 5425421
SGTC_2969 9091408 28.7 µM -1.09182223569623 0.13615705866963 no 2939 0.137455621767793 4135 4286311
SGTC_752 1896-0090 130 µM -1.09357701350896 0.135793719266802 no 2940 0.137070267617508 4180 772567
SGTC_925 2064-1272 59.6 µM -1.09396776147322 0.135712902560131 no 2941 0.136984558842743 4166 6815817
SGTC_1499 4480-0877 67.3 µM -1.0946525757732 0.135571344866448 no 2942 0.136834436316142 4125 2861909
SGTC_3296 9122258 64.045 µM -1.09557092537398 0.135381672026894 no 2943 0.136633295599173 4166 4730474
SGTC_2936 9038235 15.59 µM -1.09592501806583 0.135308587518394 no 2944 0.136555794789839 4121 4749415
SGTC_1498 4478-3555 97.6 µM -1.09748115517806 0.134987722419352 no 2945 0.136215557094802 4169 3437919
SGTC_2694 st077685 81.9 µM -1.09859300627802 0.134758786029091 no 2946 0.135972814809802 4132 2838096
SGTC_402 epigallocatechin gallate 10 µM -1.09903534526928 0.134667780067561 no 2947 0.135876324584721 4131 65064 An antioxidant.
SGTC_2429 5902844 64.44 µM -1.1007453448321 0.134316364835222 no 2948 0.135503752512856 4203 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1136 pergolide 1.05886 µM -1.10127737786565 0.134207157396367 no 2949 0.135387976888993 4163 47811 A dopamine receptor agonist.
SGTC_2691 st077356 60.2 µM -1.10230326086294 0.133996752361974 no 2950 0.135164926098909 4242 2839272
SGTC_2110 5483698 200 µM -1.10328450870982 0.133795714029911 no 2951 0.13495181590502 4168 2848765 YHR062C RPP1
SGTC_3198 9112019 49.47 µM -1.1061440195142 0.133211039531683 no 2952 0.134332094158736 4247 45595555
SGTC_1578 josamycin 24.2 µM -1.10637914297213 0.133163042979914 no 2953 0.134281224591409 4204 5282165 A P450 substrate.
SGTC_48 0382-0018 55 µM -1.10994218079278 0.132437164446434 no 2954 0.133511971262612 4262 762596
SGTC_878 0828-0289 13.7 µM -1.11307774299288 0.13180063271789 no 2955 0.132837520865491 4146 745350 YLR208W SEC13
SGTC_214 4373-3496 70 µM -1.1133202898238 0.131751482835657 no 2956 0.132785447674334 4282 3779166
SGTC_2935 9038016 29.96 µM -1.11491725894934 0.131428187500434 no 2957 0.132442940026821 4193 6463195
SGTC_1700 st030840 7.9285 µM -1.11529546133704 0.131351703328008 no 2958 0.132361914857355 4257 5499307
SGTC_2894 9048625 32.47 µM -1.1161156007036 0.131185951485471 no 2959 0.132186327559532 4230 4092861
SGTC_391 gliotoxin 8.33 µM -1.11884151061664 0.130636077831496 no 2960 0.131603879538583 4292 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1932 st074806 40.9 µM -1.12059586784642 0.130283030858137 no 2961 0.131229962352314 4289 17251235
SGTC_466 geldanamycin 89.2 µM -1.12388639935181 0.129622625499443 no 2962 0.13053061091645 4165 5288382 HSP90 inhibitor.
SGTC_1148 3909-7663 27.7 µM -1.12507503845388 0.129384638268192 no 2963 0.13027861891197 4262 4084526
SGTC_3315 9136395 68.55 µM -1.12649796991678 0.129100139848907 no 2964 0.129977399694785 4216 16876844
SGTC_505 gw-5074 63.9 µM -1.13158670925238 0.128086256768748 no 2965 0.12890411518069 4246 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1960 st011366 51.8 µM -1.1333598554728 0.127734277037768 no 2966 0.128531582633328 4232 3972846
SGTC_1302 1159-0335 255 µM -1.13346116320902 0.127714187191617 no 2967 0.128510320779792 4236 649284
SGTC_2185 6113692 200 µM -1.14528526772564 0.12538447971868 no 2968 0.126045503336601 4242 874150
SGTC_2228 7354201 200 µM -1.14942655381703 0.124575578781827 no 2969 0.125190067945578 4314 753451
SGTC_2326 6164455 177.58 µM -1.14982455081716 0.124498032194902 no 2970 0.125108070632322 4201 2888790
SGTC_435 c-PAF 6.7 µM -1.1510784328069 0.124253943824942 no 2971 0.124849984911709 4220 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_717 1532-0246 73.2 µM -1.1531136158781 0.123858475534412 no 2972 0.12443187683587 4223 9561992
SGTC_1 0258-0098 57.368 µM -1.15803013511846 0.122906755507553 no 2973 0.123425869429868 4199 6790032 YDR047W HEM12
SGTC_1246 0422-0085 105 µM -1.16096311188738 0.122341449610937 no 2974 0.122828450538067 4284 264295
SGTC_1337 1486-1011 40.3 µM -1.16118869577202 0.122298045972727 no 2975 0.122782585417668 4218 X1337
SGTC_751 0833-0568 350 µM -1.16289820577163 0.121969477716924 no 2976 0.12243540274445 4281 6954252
SGTC_2707 st078556 66.6 µM -1.16743602342648 0.121100316759362 no 2977 0.121517165260888 4197 17250899
SGTC_2244 6635614 200 µM -1.16830014560504 0.120935300272925 no 2978 0.121342858329998 4180 836499
SGTC_1109 tnp00067 928.257 nM -1.17147410318338 0.120330545833929 no 2979 0.120704130638761 4261 676295
SGTC_2960 9079389 5.97 µM -1.17342224784114 0.119960410134711 no 2980 0.120313259903493 4263 16457355
SGTC_2895 9054447 58.44 µM -1.17462527619958 0.119732243239212 no 2981 0.120072333168882 4332 2697450
SGTC_982 1491-0518 27.5 µM -1.17858737912268 0.118982953328449 no 2982 0.119281259816209 4178 3091256
SGTC_2373 9071805 200 µM -1.17964532579957 0.118783441899357 no 2983 0.119070653832934 4292 10149009
SGTC_2457 5731572 11.68 µM -1.1801416133831 0.118689931658671 no 2984 0.118971948129015 4318 2865357
SGTC_1418 3966-3099 2.4 µM -1.18075854155322 0.118573762908784 no 2985 0.11884932901958 4268 740335
SGTC_220 paclitaxel 373.376 µM -1.1815738905469 0.118420354438463 no 2986 0.11868740926062 4217 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1285 0929-0069 65.5 µM -1.18300334452971 0.118151740385843 no 2987 0.118403910958766 4299 1206237
SGTC_1591 genipin 88.4 µM -1.18403029321958 0.117959028775837 no 2988 0.118200535727714 4312 442424 A DNA cross-linking agent.
SGTC_1550 gossypolone 36.6 µM -1.19042091589139 0.116764796050323 no 2989 0.116940498137593 4299 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_104 0074-0074 590.992 µM -1.1910147165605 0.116654267727179 no 2990 0.116823903800806 4059 3943124
SGTC_626 0214-0009 33 µM -1.19576984093185 0.1157718380193 no 2991 0.115893194083966 4335 3437874
SGTC_542 3381-0244 89.3 µM -1.19687929796547 0.115566634975327 no 2992 0.115676802151222 4293 1112843
SGTC_1853 st056710 91.2 µM -1.19698078227273 0.115547877540284 no 2993 0.115657022674226 4337 269167
SGTC_24 0417-1663 219 µM -1.1983760715862 0.115290204260883 no 2994 0.115385321792733 4315 4329390
SGTC_1911 st060208 74.3 µM -1.20085513290788 0.114833394818104 no 2995 0.114903700526327 4328 688783
SGTC_1016 4226-1401 38 µM -1.20092424001991 0.114820679124451 no 2996 0.114890295213652 4271 2901613
SGTC_576 1073-0113 22.7 µM -1.20677897785869 0.113747043450933 no 2997 0.113758637024989 4421 5439563
SGTC_2148 5546263 113.568 µM -1.2098395200568 0.113188660994673 no 2998 0.113170239140153 4284 792097
SGTC_1904 st060225 78 µM -1.2099580338168 0.113167078081629 no 2999 0.113147498286807 4247 66595
SGTC_693 4161-2696 114 µM -1.21382189306344 0.112465026338885 no 3000 0.112407872115674 4342 805759
SGTC_1111 tnp00062 510.699 nM -1.21427951492342 0.112382084331712 no 3001 0.112320502714108 4344 676306
SGTC_380 3970-0968 6 µM -1.21653091032178 0.111974664955456 no 3002 0.111891371757646 4173 2891601
SGTC_1322 1348-1070 12 µM -1.21723666618852 0.111847166905358 no 3003 0.111757091676073 4299 6758089
SGTC_1247 0448-0043 5.84 µM -1.22061733371054 0.111237873527962 no 3004 0.111115470126504 4308 3089013 YGL099W LSG1
SGTC_1688 st021091 57.6 µM -1.22372968507698 0.110679042666328 no 3005 0.110527108712698 4332 3656366
SGTC_3185 9108267 49.47 µM -1.22523164532693 0.110410082673042 no 3006 0.110243977219152 4310 4910486
SGTC_1956 st077085 54 µM -1.22558786978973 0.110346361426984 no 3007 0.110176902448426 4335 24208685
SGTC_1023 4482-3888 16 µM -1.22667579425155 0.110151917329584 no 3008 0.109972234509972 4334 3303168
SGTC_1332 1480-0653 17.5 µM -1.22988122332562 0.109580442095668 no 3009 0.109370793250537 4317 5749438
SGTC_1877 wortmannin 25 µM -1.23112955637278 0.109358461840467 no 3010 0.109137206362127 4317 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3273 9137859 49.47 µM -1.2337563448481 0.108892418168132 no 3011 0.108646855554102 4415 2377234
SGTC_2310 7668677 200 µM -1.23551955957033 0.108580391315776 no 3012 0.108318600776828 4324 2197143
SGTC_1307 1187-1599 12.2 µM -1.23716537016492 0.108289721662039 no 3013 0.108012847501873 4309 1538471
SGTC_2529 gangaleoidin 93.61 µM -1.23803021995796 0.108137203587208 no 3014 0.107852427855046 4327 4565183
SGTC_1481 3346-2004 36 µM -1.23835120842324 0.108080635964125 no 3015 0.107792931887643 4390 2770522
SGTC_2062 5245942 200 µM -1.2387274465734 0.108014358842885 no 3016 0.107723225360611 4360 1376160
SGTC_2150 5556613 200 µM -1.23908916532281 0.107950667017522 no 3017 0.107656239500837 4338 743190
SGTC_2702 st077768 96.8 µM -1.23996272823888 0.107796960658818 no 3018 0.107494590172032 4292 6484119
SGTC_2858 9025781 8.96 µM -1.24211505037925 0.107418925122978 no 3019 0.107097058180685 4183 4894980 YPL153C RAD53
SGTC_1732 st034308 51.822 µM -1.24439741134783 0.107019094397018 no 3020 0.106676667590329 4192 830119
SGTC_2125 5246583 200 µM -1.24668366634462 0.106619658830353 no 3021 0.106256755090761 4340 835267
SGTC_1426 4048-4480 71.7 µM -1.24690927485971 0.106580300788091 no 3022 0.106215382772692 4327 14224343
SGTC_827 3253-0474 693 µM -1.24796135755178 0.10639690047983 no 3023 0.106022604428497 4353 5402065
SGTC_1831 st055328 12 µM -1.24899014964732 0.106217780694712 no 3024 0.105834338343475 4306 1103068
SGTC_377 3970-0964 33.1 µM -1.24908600317937 0.106201103034016 no 3025 0.105816809727791 4283 16481235
SGTC_1937 st074714 47.2 µM -1.25069450901132 0.105921519496038 no 3026 0.10552297728757 4269 17250970
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.25165654015442 0.105754557811747 no 3027 0.105347521302283 4322 641818 YHR062C RPP1
SGTC_1617 st002906 78 µM -1.2517808252186 0.105733001871265 no 3028 0.105324869498889 4319 5150859
SGTC_3300 9124615 50.48 µM -1.25251591487693 0.105605573231272 no 3029 0.105190966428197 4368 24824903
SGTC_1699 st031318 29.054 µM -1.25338242000901 0.105455506216235 no 3030 0.105033283109693 4385 5340658
SGTC_1122 capsaicin 818.572 nM -1.25457314288864 0.105249540744514 no 3031 0.104816879067519 4375 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2060 5238662 140 µM -1.25501981672184 0.105172352390897 no 3032 0.104735783117859 4298 790130
SGTC_1525 8-methoxypsoralen 92.5 µM -1.25718962407144 0.104797977344592 no 3033 0.104342489792099 4382 4114 Related to psoralen; DNA damaging agent.
SGTC_1647 st011722 22.4 µM -1.25883989703064 0.104513888674439 no 3034 0.104044083203735 4292 2854783
SGTC_2343 7990716 14.84 µM -1.26244812313799 0.10389468972723 no 3035 0.103393791085955 4341 6456862
SGTC_2762 leflunomide 42.06 µM -1.26378735838448 0.103665545170732 no 3036 0.103153179894741 4311 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_978 1416-0512 87.4 µM -1.26762737827343 0.103010547307855 no 3037 0.102465525010361 4398 6814003
SGTC_1258 0671-0043 57.1 µM -1.26802337991568 0.102943172100301 no 3038 0.102394800709405 4349 4298767
SGTC_261 5-fluorouridine 15.376 µM -1.26959270243697 0.102676484418504 no 3039 0.102114875097302 4358 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_857 0438-0306 1.35 µM -1.27503957781632 0.101754749367728 no 3040 0.10114761691792 4413 4686136
SGTC_2464 5717415 7.67 µM -1.2769569937428 0.101431716811449 no 3041 0.100808715440769 4318 5285744
SGTC_1787 fluconazole 80 µM -1.27875869629637 0.101128860146371 no 3042 0.100491021465886 4071 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3085 9117376 49.47 µM -1.28128696331305 0.100704983879693 no 3043 0.100046445124079 4429 16480349
SGTC_3352 9151559 45.5865 µM -1.28393131524604 0.10026303334913 no 3044 0.0995829944999361 4366 17159339
SGTC_2856 9022925 19.48 µM -1.28485732174969 0.100108605043418 no 3045 0.099421073531779 4386 4944862
SGTC_947 3447-0010 211 µM -1.28583887362406 0.0999451032162118 no 3046 0.0992496501366266 4314 748350
SGTC_1063 disulfiram 1.84 µM -1.29225682467942 0.0988808385364614 no 3047 0.0981341093027169 4388 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1782 st039423 80.636 µM -1.2936089744085 0.0986576780337854 no 3048 0.0979002604978601 4391 2068169
SGTC_428 3448-4153 16.5 µM -1.29383506391027 0.0986203999377387 no 3049 0.0978611991245744 4322 3834874
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.29406634693088 0.0985822761934888 no 3050 0.0978212522908816 4350 75037 A free radical scavenger.
SGTC_659 k018-0002 107 µM -1.2947106587538 0.0984761273692555 no 3051 0.097710030815587 4333 6797879 YHR007C ERG11
SGTC_2293 7624732 200 µM -1.29510302689337 0.0984115266732652 no 3052 0.0976423454401816 4246 894453
SGTC_1899 st063254 59.6 µM -1.29516461987718 0.0984013886338447 no 3053 0.0976317234794874 4305 3093813
SGTC_1305 1181-0477 144 µM -1.29887071556814 0.0977927819183902 no 3054 0.0969941505503626 4418 6252086
SGTC_465 cgp-37157 41 µM -1.29887886550364 0.0977914466018512 no 3055 0.0969927518638101 4374 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1722 st034304 3.6505 µM -1.3038697069552 0.0969762362861134 no 3056 0.0961390052263788 4327 4036148 YLR033W RSC58
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.30562854546571 0.0966901375302577 no 3057 0.0958394540279988 4409 6708784 An antioxidant flavonoid
SGTC_769 0302-0231 76 µM -1.30646777243382 0.096553844641751 no 3058 0.0956967658347442 4277 571869 YER009W NTF2
SGTC_3276 9139060 49.47 µM -1.30878572466398 0.0961781358380913 no 3059 0.0953034719288837 4477 4870619
SGTC_2917 7979103 53.79 µM -1.31522144633106 0.0951406283244185 no 3060 0.0942177447326455 4390 2980565
SGTC_2270 7924575 90.91 µM -1.31768936656643 0.0947449671846249 no 3061 0.0938038278036028 4350 1262135
SGTC_1569 carminic acid 40.6 µM -1.31791098563147 0.0947094962662122 no 3062 0.0937667238770514 4451 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1514 1189-1591 158 µM -1.31823237449682 0.0946580742265221 no 3063 0.093712935532397 4386 767698 YMR146C TIF34
SGTC_992 3909-8734 162 µM -1.32085887460179 0.0942386067528467 no 3064 0.0932742122699781 4387 4288319
SGTC_897 1000-0139 31.4 µM -1.32365612015703 0.0937933796318025 no 3065 0.092808638877612 4344 6151020
SGTC_512 prima-1 270 µM -1.32403354832577 0.093733424888036 no 3066 0.092745951559275 4385 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1333 1482-0047 286 µM -1.32423397130819 0.0937015990527169 no 3067 0.0927126758923647 4406 3811116
SGTC_1118 chelidonine 707.474 nM -1.32675047481332 0.0933026738003664 no 3068 0.0922956190317467 4367 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_338 4055-0136 114 µM -1.33207471872741 0.0924627937246852 no 3069 0.0914178184504797 4369 2900563
SGTC_2134 5324836 1.464 µM -1.33214629090158 0.0924515417044768 no 3070 0.0914060607470368 4359 699272
SGTC_468 gf-109203x 121 µM -1.33737236698041 0.0916326741011075 no 3071 0.0905505598628521 4438 2396 A protein kinase C inhibitor.
SGTC_847 0342-0274 5.54 µM -1.33853144524421 0.0914517898745994 no 3072 0.090361628417254 4386 18097
SGTC_1347 1493-0251 600 nM -1.33966263855027 0.0912755126540149 no 3073 0.090177524669933 4428 3986378
SGTC_3126 9127922 49.47 µM -1.33966677571453 0.0912748684100873 no 3074 0.0901768518507806 4394 45595682
SGTC_1477 0139-0234 16 µM -1.34006240861364 0.0912132755806206 no 3075 0.0901125280530047 4403 620880
SGTC_2054 5233173 129 µM -1.34354622609927 0.0906722387464433 no 3076 0.0895475841673991 4419 6889
SGTC_180 1486-1293 102.781 µM -1.34369027799437 0.0906499188786351 no 3077 0.0895242812146221 4344 4140536
SGTC_266 formosanin C 406 nM -1.34459180393039 0.0905103261414978 no 3078 0.0893785458017227 4237 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1799 st045822 46.1415 µM -1.3475413280688 0.090054735519903 no 3079 0.0889029761803984 4384 3674992
SGTC_228 caffeine 993.056 µM -1.34930657480706 0.0897828875129412 no 3080 0.0886192573394094 4383 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1008 4106-0037 6 µM -1.34975643043188 0.0897137073806611 no 3081 0.0885470623580666 4411 2905394
SGTC_1492 4158-0558 28.5 µM -1.35073745554008 0.0895629798864105 no 3082 0.0883897747308051 4412 3967268
SGTC_594 1487-1584 10.8 µM -1.35320132878532 0.0891852539094032 no 3083 0.0879956604428589 4357 5013332
SGTC_739 1486-1183 203 µM -1.35374434089147 0.0891021666684572 no 3084 0.0879089782274943 4404 4346692
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.36048580949282 0.0880754353105065 no 3085 0.0868381202324371 4315 17037758
SGTC_615 k087-0205 167 µM -1.36114571967444 0.0879754063772938 no 3086 0.0867338218923602 4439 9642773
SGTC_3027 9089541 49.47 µM -1.36330178530128 0.0876491813083082 no 3087 0.0863937098065822 4405 9943819
SGTC_112 phenothiazine 287.218 µM -1.36422753221362 0.087509387793717 no 3088 0.0862479827553691 4374 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_746 1095-0025 46.6 µM -1.36428234563819 0.0875011158480398 no 3089 0.0862393600331675 4423 6749286
SGTC_1607 st000305 50.6 µM -1.3662155493049 0.0872097473536497 no 3090 0.0859356592065982 4422 5457690
SGTC_1088 bifonazole 369 nM -1.36645143288634 0.0871742451125734 no 3091 0.0858986574181213 4397 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.37642495484292 0.0856830124798835 no 3092 0.0843450531982277 4429 5024745
SGTC_812 4251-0442 148 µM -1.37652568607367 0.0856680492650756 no 3093 0.0843294702819859 4444 5723007
SGTC_1272 0839-0021 27 µM -1.37816912613651 0.0854241991884769 no 3094 0.0840755385263256 4454 5027250
SGTC_996 3970-0799 1.8 µM -1.37949986777192 0.0852271278438104 no 3095 0.0838703434877112 4403 6615648 YGL040C HEM2
SGTC_152 4469-0003 551.229 µM -1.38411829556603 0.0845458209312288 no 3096 0.0831611178471303 4405 697280
SGTC_2004 4023728 41.89 µM -1.38691835518048 0.0841347524024171 no 3097 0.082733330063889 4383 360084 YDR527W RBA50
SGTC_2174 5790901 200 µM -1.38887052137384 0.0838490494999247 no 3098 0.0824360629727724 4398 786020
SGTC_1829 berberine 14.4 µM -1.38890319612895 0.0838442737007732 no 3099 0.0824310942596465 4384 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1358 1509-0022 2.48 µM -1.39069525368065 0.083582656207358 no 3100 0.0821589287540794 4456 3258434
SGTC_770 0389-1121 67.2 µM -1.39516115937251 0.0829333606074959 no 3101 0.0814836233296653 4481 6753108
SGTC_1603 st002045 67.8 µM -1.40112449504586 0.0820722799686993 no 3102 0.0805884239364808 4423 5887985
SGTC_2486 5283202 22.39 µM -1.40406228840516 0.0816505593461064 no 3103 0.0801501510592165 4452 1377751
SGTC_2204 7233102 200 µM -1.40469567579355 0.0815598509681946 no 3104 0.0800558960905105 4390 2172480
SGTC_2665 lovastatin 100 µM -1.4105307061869 0.0807277787407311 no 3105 0.0791915180977103 4465 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2428 5615643 7.78 µM -1.41085373219846 0.0806819033541079 no 3106 0.0791438735569686 4425 2253075
SGTC_588 3970-1144 52.9 µM -1.41133627431864 0.0806134105442334 no 3107 0.0790727417113881 4328 1888707
SGTC_1889 st059080 5.18 µM -1.41428104878691 0.0801963759472169 no 3108 0.0786396995119591 4426 176925 Isolated from Daphnopsis sellowiana.
SGTC_1949 st076024 69.1 µM -1.41634964343197 0.0799044011294509 no 3109 0.0783365798591128 4398 2921930
SGTC_2603 homopterocarpin 100 µM -1.4252247164504 0.0786608333925802 no 3110 0.077046126926494 4430 101795 A weak amylase inhibitor.
SGTC_2546 rhodinyl acetate 100 µM -1.43759107991512 0.0769525996527102 no 3111 0.0752750566710991 4404 6708682
SGTC_411 enrofloxacin 100 µM -1.44092169126646 0.0764973792715525 no 3112 0.0748034036240806 4495 71188 A bacterial gyrase inhibitor.
SGTC_2880 9042983 58.44 µM -1.44385598193649 0.0760980270552328 no 3113 0.0743897453947861 4410 6464714
SGTC_2611 pyromycin 23.93 µM -1.44583483108459 0.0758296062403898 no 3114 0.0741117670438685 4427 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3207 9114163 49.47 µM -1.44889479601292 0.0754159580437218 no 3115 0.0736834823377066 4446 849233
SGTC_713 1488-1073 324 µM -1.45125241002781 0.0750984288023191 no 3116 0.0733547938780334 4507 3312542
SGTC_84 0443-0269 128.823 µM -1.45468939074577 0.0746373556288516 no 3117 0.0728776355016683 4409 6150058
SGTC_513 4245-1575 41.7 µM -1.4582173896216 0.0741663225383763 no 3118 0.0723903160297244 4303 719745
SGTC_646 4092-0839 27.3 µM -1.45856223057757 0.0741204039368087 no 3119 0.0723428177085454 4491 877796
SGTC_3019 9081971 49.47 µM -1.46935856515101 0.0726937346028657 no 3120 0.070867779813902 4481 16451803
SGTC_135 0933-0004 26.348 µM -1.47157258772521 0.0724037807275358 no 3121 0.0705681662548587 4410 21230617 YGL099W LSG1
SGTC_3325 9138760 55.175 µM -1.47492920612234 0.071965880824681 no 3122 0.0701157886543785 4426 43844959
SGTC_3224 9130643 49.47 µM -1.47495825077108 0.0719621005805909 no 3123 0.0701118840119029 4487 17644395
SGTC_3193 9111931 49.47 µM -1.4758449449264 0.0718467680610572 no 3124 0.0699927609987992 4481 17087244
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.4762013955907 0.0718004444061115 no 3125 0.0699449175061109 4478 688669
SGTC_2075 5212009 200 µM -1.47826594900899 0.0715325894033792 no 3126 0.0696683040032991 4414 780898
SGTC_2544 sphondin 68.51 µM -1.47882853553964 0.0714597325725047 no 3127 0.0695930735988953 4442 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2496 diffractaic acid 79.83 µM -1.48281925811152 0.0709445544316199 no 3128 0.0690612190004303 4469 94870 An apoptosis inducer which activates caspases.
SGTC_1701 st028638 40.4 µM -1.4837135440843 0.0708294997670997 no 3129 0.0689424657870536 4499 3490878
SGTC_34 0469-0683 81.75 µM -1.48385768208207 0.07081096906642 no 3130 0.0689233402826466 4456 3690923
SGTC_1798 st045719 60.953 µM -1.48455064513707 0.0707219321952768 no 3131 0.0688314489072468 4439 3980186
SGTC_2098 5376439 882.5 nM -1.48692584044096 0.0704174027372623 no 3132 0.0685171992886173 4533 2844116
SGTC_2854 9024559 71.43 µM -1.4884159974032 0.0702268614560127 no 3133 0.0683206101549889 4488 3163529
SGTC_681 1642-0006 26.6 µM -1.49328700835465 0.0696067878412789 no 3134 0.0676810374174645 4492 4446530
SGTC_3057 9095946 49.47 µM -1.49671396812128 0.0691730722883104 no 3135 0.0672338500725655 4549 24540043
SGTC_1706 st031321 9.9705 µM -1.49843549935427 0.0689559827549031 no 3136 0.0670100694957007 4517 6103185
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.4989777183841 0.0688877163965827 no 3137 0.0669397062698781 4503 23847180
SGTC_379 3970-0972 5.9 µM -1.50100392882453 0.0686330738777375 no 3138 0.0666772726969504 4495 2898042 YBL034C STU1
SGTC_2719 novobiocin 32.65 µM -1.50265248990562 0.0684264282815631 no 3139 0.0664643400853698 4524 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_263 alizarin 107.927 µM -1.50376863493322 0.068286793286593 no 3140 0.066320474903756 4536 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1633 st005664 67.9 µM -1.51295365552529 0.067146040991835 no 3141 0.0651457156484015 4481 2063822
SGTC_225 nsc-122657 1.016 µM -1.51388321971446 0.0670314179180384 no 3142 0.0650277303894987 4507 275685
SGTC_2545 solidagenone 89.61 µM -1.51759023738142 0.0665758161022297 no 3143 0.0645588647410534 4434 6708572 An anti ulcer agent
SGTC_2287 7945887 168.79 µM -1.51794377410438 0.0665324910492152 no 3144 0.064514286739637 4518 1245853
SGTC_432 NS 1619 61.3 µM -1.51926228855482 0.0663711028192503 no 3145 0.0643482440463909 4483 4552 A K+/calcium channel activator.
SGTC_571 k831-0106 44.2 µM -1.52135119099741 0.0661160386521854 no 3146 0.0640858651906301 4399 4783639
SGTC_2383 9036125 200 µM -1.52201431737467 0.0660352269935078 no 3147 0.0640027466428733 4456 79580
SGTC_1115 galangin 695.678 nM -1.5221859662546 0.0660143215374908 no 3148 0.063981245243027 4569 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_759 3486-0358 89.3 µM -1.52393372073962 0.0658017508904819 no 3149 0.0637626344204977 4490 875103
SGTC_2701 st077767 14.721 µM -1.52581215826444 0.0655738778609786 no 3150 0.0635283259429592 4474 5721188
SGTC_2413 inermin 26.06 µM -1.52667410543837 0.0654695201764954 no 3151 0.0634210347631731 4530 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1797 st048695 56.8 µM -1.53365170808846 0.0646294633310138 no 3152 0.0625576800722447 4476 592262 YIL048W NEO1
SGTC_2214 7179297 48.276 µM -1.5400336806386 0.0638684692161709 no 3153 0.06177607190499 4579 769744
SGTC_2760 etidronate 98.04 µM -1.54226706336955 0.0636038103029128 no 3154 0.0615043546144296 4472 3305 A chelator and antioxidant.
SGTC_186 3455-3465 67.277 µM -1.54482311335053 0.0633019629386643 no 3155 0.0611945274856192 4521 755278
SGTC_3107 9121808 49.47 µM -1.54771718865612 0.0629615452127438 no 3156 0.060845200924327 4470 662681
SGTC_1770 st043884 66.3 µM -1.54791675284133 0.0629381239901041 no 3157 0.0608211703080259 4530 670149
SGTC_1792 st045773 43.6 µM -1.54941540032657 0.0627624567503325 no 3158 0.0606409470160431 4499 2919270
SGTC_2998 9066762 71.4286 µM -1.55284715770588 0.0623616351417367 no 3159 0.0602298267463025 4527 4945196
SGTC_3010 9080089 71.4286 µM -1.5575096163186 0.0618202721321286 no 3160 0.0596747696241367 4531 17027233
SGTC_1370 2001-0092 44.6 µM -1.55844633622595 0.0617119524381047 no 3161 0.0595637398784759 4503 790957
SGTC_1086 cerivastatin 2.18 µM -1.55975438501743 0.0615609413002319 no 3162 0.0594089673570512 4548 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1433 4060-0023 7.6 µM -1.56815129688206 0.0605983998505695 no 3163 0.0584229137193131 4549 3840627
SGTC_2674 ligustilide 100 µM -1.57165195578512 0.0602006118907527 no 3164 0.0580156450274363 4578 5319022 A signalling regulator.
SGTC_2258 7960471 200 µM -1.57176530728349 0.0601877657464213 no 3165 0.0580024950367262 4536 2974708
SGTC_2233 sulbentine 40.3845 µM -1.5722184193743 0.0601364359106239 no 3166 0.0579499525661373 4538 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_525 k781-2675 26.7 µM -1.5751299849898 0.0598074226574876 no 3167 0.0576132220454185 4477 3651118 YDL195W SEC31
SGTC_1147 3809-1045 12.3 µM -1.57680557134765 0.0596187180144462 no 3168 0.0574201346584152 4551 325925
SGTC_41 0478-0632 82.643 µM -1.58037841833472 0.0592179021141149 no 3169 0.0570101154741133 4505 3750424
SGTC_2089 5281248 129.67 µM -1.5841622245708 0.0587957272159478 no 3170 0.0565784036026889 4518 2737878
SGTC_1217 1183-1422 255 µM -1.58791201511133 0.0583796814915393 no 3171 0.0561531180876405 4573 2849664
SGTC_2832 7992762 51.95 µM -1.59089448030384 0.0580504255809317 no 3172 0.0558166624943713 4467 2985177
SGTC_3321 9137793 26.8275 µM -1.5962066575916 0.0574675921434957 no 3173 0.0552213308507622 4519 4904192
SGTC_2315 7733312 200 µM -1.59950837334388 0.0571076656037427 no 3174 0.0548538447893984 4454 726316
SGTC_2497 7-hydroxyflavone 100 µM -1.60873199349994 0.0561115792816786 no 3175 0.0538374784401106 4552 5281894
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.61029520299639 0.0559441295944821 no 3176 0.0536667129907896 4423 88881 An O-methylated flavonoid and antioxidant.
SGTC_2495 cafestol 54.53 µM -1.61147922911687 0.0558175602641501 no 3177 0.0535376554154893 4540 16667697 An anti-infammatory.
SGTC_507 nimesulide 162 µM -1.61316203520051 0.0556380615205366 no 3178 0.0533546545811633 4571 4495 A COX2 inhibitor.
SGTC_458 nppb 133 µM -1.62372301077898 0.0545219413881034 no 3179 0.0522174688532444 4587 4549 A chloride channel blocker.
SGTC_1973 st070275 50.2 µM -1.62997420477795 0.0538696827042925 no 3180 0.0515534744531233 4541 17118334
SGTC_1927 st060202 13.8 µM -1.63289288805074 0.0535672663498011 no 3181 0.0512457630908947 4497 688887
SGTC_1044 1222-0021 1.78 µM -1.63348029401985 0.0535065657789521 no 3182 0.0511840109620071 4478 4306703
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.63935331865427 0.052902659189245 no 3183 0.0505698488335306 4584 23665772 A membrane-active detergent.
SGTC_977 1348-1378 135 µM -1.63939552228889 0.052898339155201 no 3184 0.0505654567946023 4545 X977
SGTC_2226 7298446 200 µM -1.64077184098977 0.0527576101851104 no 3185 0.0504223928115006 4584 3283010
SGTC_1568 digitonin 820 nM -1.6458157907753 0.0522444024274667 no 3186 0.0499008451160691 4542 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_46 0329-0187a 2.197 µM -1.64878189910694 0.0519444653581909 no 3187 0.0495961622661704 4558 46494817
SGTC_222 nsc-310342 10.666 µM -1.65293023442074 0.0515272765958003 no 3188 0.0491725315044354 4589 432556
SGTC_695 3505-6186 243 µM -1.65932229759697 0.0508896617323535 no 3189 0.0485254322432893 4558 1819379
SGTC_2412 st077135 33.4 µM -1.65989076061834 0.0508332624596523 no 3190 0.0484682152557187 4576 13258915
SGTC_989 1501-0895 10.3 µM -1.66272022427418 0.0505532810861921 no 3191 0.0481842259629232 4562 2830112
SGTC_275 trichlorophene 5.69 µM -1.66509666826337 0.0503190773318806 no 3192 0.047946735669855 4601 62616
SGTC_249 wiskostatin 11.211 µM -1.67270239564438 0.0495753241468662 no 3193 0.0471929487027871 4552 2775510 A n-wasp and actin depolymerizer.
SGTC_2261 9010538 184.68 µM -1.6730877295704 0.0495378776504331 no 3194 0.0471550133741719 4544 6457250
SGTC_168 3970-0862 530.542 µM -1.68598326226544 0.0482976654728323 no 3195 0.0458995116275516 4506 3135186
SGTC_2190 6049624 200 µM -1.68679174613867 0.0482207454753479 no 3196 0.045821701558728 4509 2265554
SGTC_1553 gossypol 38.6 µM -1.68705795483514 0.0481954395623946 no 3197 0.0457961043241586 4533 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3280 9140961 49.47 µM -1.69156405180018 0.0477686980656348 no 3198 0.0453645627551049 4610 4901226
SGTC_1791 st048313 56.1 µM -1.69530258512042 0.0474169483133288 no 3199 0.045009017334829 4598 1204976
SGTC_696 1560-0013 611 µM -1.69891835490743 0.047078726317473 no 3200 0.0446672840473366 4614 1650269
SGTC_1975 st070967 30.8 µM -1.70246832875937 0.0467485434059089 no 3201 0.0443338053271518 4586 261391
SGTC_1070 indatraline 8.81 µM -1.70578085106017 0.0464421238579463 no 3202 0.0440244448372346 4626 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.70696375755839 0.0463330924457678 no 3203 0.0439143944660547 4602 390807
SGTC_2271 7849410 118.62 µM -1.70819260367934 0.0462200444022617 no 3204 0.043800305236128 4529 972430
SGTC_1303 1160-0052 261 µM -1.70971929476132 0.0460799046815074 no 3205 0.0436588965167768 4554 3562476
SGTC_1184 1269-1718 139 µM -1.71016073331738 0.0460394473376434 no 3206 0.0436180773030146 4629 5403821
SGTC_1552 6-methylflavone 10.6 µM -1.72133072795797 0.0450251923864983 no 3207 0.0425954132910026 4550 689013
SGTC_712 r015-0009 80.6 µM -1.72516998667821 0.0446807625625863 no 3208 0.0422484214159679 4631 6813872 YLR060W FRS1
SGTC_58 0957-0393 9 µM -1.73593120431425 0.0437266448622824 no 3209 0.0412879997718225 4146 6997992
SGTC_2133 5320837 200 µM -1.74889522029611 0.0425991252526737 no 3210 0.0401545664762221 4609 2841355
SGTC_716 1683-5115 658 µM -1.74911717942053 0.0425800274501408 no 3211 0.0401353831136991 4603 723597
SGTC_2580 diallyl disulphide 81.36 µM -1.76589725707039 0.0411561638272546 no 3212 0.0387065437368541 4582 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1644 st010134 20.9 µM -1.76930663580312 0.0408716352955557 no 3213 0.038421358324316 4604 3818134
SGTC_2014 4013930 200 µM -1.77169737614574 0.0406730703255941 no 3214 0.0382224027286765 4585 64556
SGTC_348 k064-0012 10.7 µM -1.78210490423614 0.0398177680212304 no 3215 0.0373660631080821 4592 5066323
SGTC_1508 1080-0625 72.9 µM -1.7909869677073 0.039099446042519 no 3216 0.036647693175716 4582 767111
SGTC_743 1275-0778 158 µM -1.79554199530132 0.0387351785235917 no 3217 0.0362836940376437 4604 2849257 YMR203W TOM40
SGTC_12 0849-0099 9.267 µM -1.79584934314492 0.038710699681321 no 3218 0.0362592403713699 4603 6071388
SGTC_1177 0983-0204 23.6 µM -1.80047743546972 0.0383436147957107 no 3219 0.0358926417004433 4665 766818
SGTC_405 ebelactone b 50 µM -1.80172208884415 0.0382453787436896 no 3220 0.0357945704959761 4601 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_56 0957-0365 83.25 µM -1.82088822744277 0.0367584107244433 no 3221 0.034311924546553 4579 6752360
SGTC_834 0312-0008 75.7 µM -1.83314089279155 0.0358328303987867 no 3222 0.0333908105882612 4664 6385573 YIL048W NEO1
SGTC_31 0508-1974 57.237 µM -1.83614082321929 0.0356091462727848 no 3223 0.0331684160082411 4603 6810525
SGTC_3203 9113543 49.47 µM -1.83644319191809 0.035586664359893 no 3224 0.0331460682852342 4630 17018012
SGTC_335 4077-0256 27.6 µM -1.83706728818563 0.0355402979431394 no 3225 0.0330999812706622 4550 3121989
SGTC_2458 5808907 16.39 µM -1.83757449417796 0.0355026522282061 no 3226 0.0330625650364059 4715 2731747
SGTC_2259 7964009 200 µM -1.83969870699264 0.0353453444656052 no 3227 0.0329062417498761 4644 313134
SGTC_1562 morin hydrate 59.1 µM -1.84435522918466 0.0350025071514319 no 3228 0.0325656937477612 4640 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_540 1187-0821 17.3 µM -1.85313806197358 0.0343632985665125 no 3229 0.0319312862848972 4579 847520
SGTC_2476 5806916 10.51 µM -1.85517472707904 0.0342164498246257 no 3230 0.031785639717244 4594 2870194
SGTC_2932 9016711 44.54 µM -1.85648220906285 0.0341224492123522 no 3231 0.0316924282823498 4616 7117328
SGTC_1084 voriconazole 435 nM -1.85782562734028 0.0340260862419402 no 3232 0.0315968902979217 4668 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2381 9035592 200 µM -1.8642457947886 0.0335686550767769 no 3233 0.0311435975237495 4659 4749657
SGTC_1003 4049-0218 100 µM -1.86662369561698 0.0334005215211333 no 3234 0.03097707808875 4651 295161
SGTC_2567 aureobasidin a 60 nM -1.87096931407574 0.0330950487488861 no 3235 0.0306746672139558 4672 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_129 0088-0017 176.636 µM -1.87820684624636 0.0325914019750049 no 3236 0.0301764369808467 4525 182446
SGTC_533 1222-0222 6.71 µM -1.87914677757492 0.0325264600929282 no 3237 0.0301122272290714 4676 3982874
SGTC_701 4424-0219 185 µM -1.88589668316643 0.0320632237988303 no 3238 0.0296544392904758 4664 2911779
SGTC_2246 7293507 91.5585 µM -1.88895141656712 0.031855379471074 no 3239 0.0294491694738688 4671 887656
SGTC_1645 Cervolide 78 µM -1.8915532799539 0.0316792272725805 no 3240 0.0292752628732477 4682 23173 A fragrance.
SGTC_2792 7535235 81.82 µM -1.89662439151126 0.0313382142759154 no 3241 0.0289387645065736 4612 1281891
SGTC_1938 st074717 56.4 µM -1.9083448901478 0.0305616598708036 no 3242 0.0281733273145624 4554 17250979
SGTC_3127 9126946 49.47 µM -1.91703085102083 0.0299965019655207 no 3243 0.0276170061915508 4618 27243249
SGTC_1245 0418-0076 17.2 µM -1.91935608480234 0.0298466883043934 no 3244 0.0274696423200729 4652 6790114
SGTC_628 1636-0253 16 µM -1.92532479051785 0.0294649669753481 no 3245 0.0270943690527361 4666 4456143
SGTC_359 0081-0058 15.9 µM -1.92627906322032 0.0294043150498042 no 3246 0.0270347691154956 4638 3494159
SGTC_2441 5730946 39.09 µM -1.9280188693749 0.0292940027588796 no 3247 0.0269263895869066 4672 1774275
SGTC_1905 st060207 84.5 µM -1.92893239687319 0.0292362183589925 no 3248 0.0268696276540394 4664 1948547
SGTC_2512 diallyl trisulfide 49.23 µM -1.9346840971585 0.0288745702403805 no 3249 0.0265145365197919 4689 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_131 0141-0277 33.849 µM -1.93590557538579 0.0287982483384126 no 3250 0.0264396333918081 4617 1547771
SGTC_2515 chrysin 20.77 µM -1.93591467587006 0.0287976803408386 no 3251 0.0264390759989138 4673 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2411 st077133 39.94 µM -1.94062948428232 0.0285046601396537 no 3252 0.0261516175705824 4624 1403142 YNL221C POP1
SGTC_2041 5107442 45.335 µM -1.94172650180725 0.028436838566778 no 3253 0.026085109317881 4679 793005
SGTC_809 3998-0021 90 µM -1.94365010939873 0.0283182383601735 no 3254 0.0259688293704014 4645 715485
SGTC_2520 obtusaquinone 4.71 µM -1.94702815827627 0.0281109607238705 no 3255 0.0257656794593726 4679 5967872
SGTC_2750 bromebric acid 70.15 µM -1.95390175178478 0.0276930950228228 no 3256 0.0253564186870732 4643 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_376 3970-0862 59.1 µM -1.95637675985195 0.0275439052620884 no 3257 0.0252103939021785 4681 3135186
SGTC_2772 vinpocetine 57.06 µM -1.95847174074188 0.0274181471273472 no 3258 0.0250873419246869 4661 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2802 7925815 54.55 µM -1.96344355366116 0.027121613123073 no 3259 0.0247973286271845 4654 1262923
SGTC_1806 st050005 60.3 µM -1.9643843963525 0.0270658006095211 no 3260 0.0247427654919769 4713 5194765
SGTC_1758 st042942 75.2445 µM -1.96779012359778 0.0268645674721969 no 3261 0.0245460955165873 4651 669317
SGTC_603 3794-0023 45.9 µM -1.9692977161665 0.0267758885095067 no 3262 0.0244594566527507 4709 3802260
SGTC_1808 st050063 61.5 µM -1.97161399251221 0.0266401178753381 no 3263 0.0243268443139669 4654 4011993
SGTC_2097 5376186 200 µM -1.9767379387904 0.0263418153853951 no 3264 0.0240356300078381 4683 742755
SGTC_353 1988-1175 58.3 µM -1.98242305571326 0.0260141156101971 no 3265 0.0237159556334248 4532 2788357
SGTC_310 1273-0058 1.06 µM -1.99157394754947 0.0254938079901662 no 3266 0.0232089121061971 4341 2734232
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.99536770979804 0.0252806697546644 no 3267 0.0230013950030103 4704 688788
SGTC_1641 st009299 47.1 µM -2.00200713814746 0.024911251480516 no 3268 0.0226419819096597 4651 4046054
SGTC_1056 3448-1962 115 µM -2.00833148138379 0.0245635846498486 no 3269 0.0223040393319613 4644 715507
SGTC_2754 granisetron 64.02 µM -2.01054301640264 0.0244429752888739 no 3270 0.0221868740986165 4662 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1160 4092-0570 10.5 µM -2.02051212038624 0.0239054492764563 no 3271 0.0216651471072891 4683 4994975
SGTC_2471 5466956 24.79 µM -2.02378631698553 0.0237310890311922 no 3272 0.021496071343637 4706 724419
SGTC_567 1080-0542 68.4 µM -2.03222932695411 0.0232864024389526 no 3273 0.0210652226348645 4610 5950415
SGTC_2231 micatex 6.853 µM -2.03721382927035 0.0230271804112808 no 3274 0.020814309297912 4705 20737 An antifungal of unknown mechanism.
SGTC_1887 st057648 70.8 µM -2.04679342673004 0.0225358084505814 no 3275 0.0203391856745666 4700 688672
SGTC_3259 9138485 49.47 µM -2.06322848457563 0.0217133920921847 no 3276 0.0195454625171145 4664 17646153
SGTC_324 1315-0088 19.6 µM -2.0672289775896 0.0215170880492829 no 3277 0.019356291459162 4694 6787421
SGTC_2811 7967822 32.47 µM -2.08260590419559 0.020776449466373 no 3278 0.0186435803018964 4693 2232244
SGTC_1821 st053465 65.6 µM -2.09125416698848 0.0203694668255916 no 3279 0.0182526430043521 4719 675086
SGTC_204 PMA1.184 62.41 µM -2.09752395868162 0.0200786564553218 no 3280 0.0179736092799265 4703 2252213 YGL008C PMA1
SGTC_2724 maprotiline 69.64 µM -2.1142382676938 0.0193205558673483 no 3281 0.0172474609722623 4656 4011 A tricyclic antidepressant.
SGTC_3210 9128157 49.47 µM -2.1220270642048 0.0189756773395846 no 3282 0.0169177326927914 4640 17590849
SGTC_1819 st053448 58.6 µM -2.12569263189601 0.0188151909533274 no 3283 0.016764430421336 4683 2857616
SGTC_218 alverine citrate 93.75 µM -2.12806272481833 0.0187120391738275 no 3284 0.0166659416639689 4737 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2576 guaiol 23.12 µM -2.13160508826144 0.0185587650006896 no 3285 0.016519662554763 4643 227829
SGTC_2181 6316240 54.2555 µM -2.14629402001754 0.0179345469833703 no 3286 0.0159247642010135 4723 12779990
SGTC_3304 9125678 46.087 µM -2.14645781211642 0.017927688702679 no 3287 0.0159182355873495 4686 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2751 anetholtrithion 17.25 µM -2.15811809712104 0.0174451643982344 no 3288 0.0154593255348246 4670 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1907 st060210 83.7 µM -2.16692074094017 0.0170882803674735 no 3289 0.0151204490778865 4708 688793
SGTC_176 1486-1328 72.834 µM -2.18169735193365 0.0165032221828338 no 3290 0.0145659382487458 4719 22310231
SGTC_1976 st070609 63.5 µM -2.19106466716374 0.0161412867478949 no 3291 0.0142235565701098 4708 682556
SGTC_3281 9140613 49.47 µM -2.19136691895228 0.0161297224792977 no 3292 0.014212625507005 4704 16013766
SGTC_2964 9083345 53.42 µM -2.19166424231911 0.0161183537012998 no 3293 0.0142018797440363 4695 17741579
SGTC_688 0527-0193 473 µM -2.19430923364819 0.0160175188475635 no 3294 0.0141065930454555 4743 4007154
SGTC_1744 st037937 38.9 µM -2.19637905203096 0.0159389888407557 no 3295 0.0140324118757452 4718 1016152
SGTC_1656 st012921 11 µM -2.19742438835913 0.0158994538288439 no 3296 0.013995075539495 4650 6732821
SGTC_415 dibenzyl ketone 100 µM -2.20766583566566 0.0155165454551067 no 3297 0.0136337880397808 4716 7593
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -2.22140035618997 0.0150154818524576 no 3298 0.0131619284675436 4688 6708760
SGTC_2795 7780010 54.55 µM -2.22271039405189 0.0149684237123424 no 3299 0.0131176672863746 4690 953673
SGTC_3310 9130229 44.1445 µM -2.22902459408885 0.0147433840989266 no 3300 0.0129061342185011 4716 7761258
SGTC_2913 7966556 36.57 µM -2.23063996136364 0.0146862816978686 no 3301 0.0128524937640937 4640 2976516
SGTC_1174 0739-0097 51.1 µM -2.23224018439137 0.0146299023413568 no 3302 0.0127995464268426 4752 728447
SGTC_2 0422-0095 29 µM -2.23622509727001 0.0144903138351446 no 3303 0.0126685150136344 4664 6790840
SGTC_1385 3091-4834 14.1 µM -2.23932257668778 0.0143826048000351 no 3304 0.0125674674669957 4715 4072814
SGTC_2460 5552655 174.22 µM -2.25046238218839 0.0140009177039424 no 3305 0.012209804437329 4716 5401989
SGTC_2568 diosmetin 100 µM -2.25273136526135 0.0139242542577839 no 3306 0.0121380460227929 4731 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3034 9090421 49.47 µM -2.26341884904384 0.0135679984904181 no 3307 0.0118049409495754 4715 17173761
SGTC_3329 9141233 27.5565 µM -2.26880782640166 0.0133913655146367 no 3308 0.0116400074174214 4704 4909101 YNL103W MET4
SGTC_2213 7173844 200 µM -2.28342467143006 0.0129222369270143 no 3309 0.0112026826885389 4750 892728
SGTC_3286 9117135 37.221 µM -2.34668395834143 0.0110521220452574 no 3310 0.00947065672738131 4704 3438150
SGTC_3233 9132340 49.47 µM -2.35135827626537 0.0109237844928861 no 3311 0.0093525068450738 4745 17682950
SGTC_2628 lathosterol 100 µM -2.35138117182906 0.0109231590798634 no 3312 0.00935193131578303 4730 6710616
SGTC_81 0411-0046 9.971 µM -2.38225212022751 0.0101077259761845 no 3313 0.00860355607912693 4767 12925265
SGTC_2211 7117706 200 µM -2.42802958940927 0.00899640279516157 no 3314 0.00759055232800335 4738 822771
SGTC_224 benfluorex 43.875 µM -2.45040649311656 0.00849322027482364 no 3315 0.00713475100152572 4770 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1974 st069448 26.9 µM -2.4900513350443 0.00766215068355844 no 3316 0.00638623227499682 4751 6323587 YNR016C ACC1
SGTC_1308 1187-1617 41.4 µM -2.52091108855561 0.00706566322089707 no 3317 0.0058525712013218 4771 2882570
SGTC_2304 7443016 91.4 µM -2.52099106303484 0.00706417219611524 no 3318 0.00585124121071568 4738 939854
SGTC_1558 st069300 45.6 µM -2.57392201904548 0.00613620112578639 no 3319 0.00502764668330706 4769 24208000
SGTC_638 3970-0837 4.09 µM -2.58264468664896 0.00599411107000662 no 3320 0.00490231204900963 4778 4118451 YLR208W SEC13
SGTC_3103 9120822 49.47 µM -2.58890012775355 0.00589401518881844 no 3321 0.00481415073874843 4769 17141819
SGTC_3188 9110789 49.47 µM -2.6099017706353 0.00556871682568236 no 3322 0.00452841123774243 4751 849217
SGTC_258 haloperidol 50.781 µM -2.62095792873539 0.00540395668372388 no 3323 0.00438415409651192 4769 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_524 r073-0010 27.8 µM -2.66324085888136 0.00481311860599036 no 3324 0.00386959981942373 4748 2772106
SGTC_738 1315-0003 72.4 µM -2.67691646238706 0.00463474576077299 no 3325 0.0037151579214828 4774 6251474
SGTC_1059 3448-6867 171 µM -2.68046013002085 0.00458949822371216 no 3326 0.00367605110726913 4764 3934407
SGTC_1746 st038117 42 µM -2.69314733654162 0.00443071632312606 no 3327 0.00353904912029527 4769 2898218
SGTC_1715 st032160 10.2275 µM -2.73513915169517 0.00393959795760266 no 3328 0.00311769552897394 4718 5289825
SGTC_1141 3253-0389 52.6 µM -2.74844185010203 0.00379451769353794 no 3329 0.00299396276293855 4771 5402031
SGTC_444 curcumin 90.4 µM -2.78900700153681 0.00338121953237604 no 3330 0.00264349610157957 4721 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_4 0960-0234 25.671 µM -2.81760026395342 0.00311469566476752 no 3331 0.00241920027261994 4723 6821112
SGTC_174 3553-0389 74.3 µM -2.82436066414437 0.00305451267963935 no 3332 0.00236875209142483 4781 738071
SGTC_2759 disulfiram 3.38 µM -2.82942147184045 0.0030101476297345 no 3333 0.00233161212151539 4742 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1756 st041558 35.5 µM -2.83246396253443 0.00298375619306579 no 3334 0.00230953862570185 4793 3955792
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -2.85779879829408 0.00277196351368583 no 3335 0.00213295394400654 4757 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3313 9133968 57.047 µM -2.86066092984614 0.00274891042106722 no 3336 0.00211379464602248 4784 1494643
SGTC_1762 st045503 25.4615 µM -2.88021077535641 0.00259601873450581 no 3337 0.00198704695578386 4779 4645554
SGTC_932 2857-0803 154 µM -2.88858016152213 0.00253294686961391 no 3338 0.00193492688844422 4769 674898
SGTC_103 0844-0104 51.839 µM -2.90884927359264 0.00238589923822467 no 3339 0.00181380854584895 4670 5375804
SGTC_1057 3448-5381 134 µM -2.91557775959184 0.00233882128331344 no 3340 0.00177515311689215 4779 5497911
SGTC_1749 st037932 54.2 µM -2.9506709242452 0.00210664036152379 no 3341 0.00158542273737704 4769 594497
SGTC_3302 9125395 16.351 µM -2.96227779151718 0.00203457826946767 no 3342 0.00152686069117669 4767 17599668
SGTC_43 0570-0105 72.5 µM -2.99270594075882 0.00185615978643602 no 3343 0.00138258018251339 4766 1114046 YDL195W SEC31
SGTC_1739 st037196 92.5 µM -3.00049929287945 0.00181281129514725 no 3344 0.00134768689778559 4780 612214
SGTC_893 0958-0369 48.9 µM -3.09179460361032 0.0013692692555708 no 3345 0.000994752283739205 4706 6819948
SGTC_1253 0550-0034 176 µM -3.25932203415297 0.000803493553410449 yes 3346 0.000558394111081941 4786 5969915
SGTC_1208 2323-2347 50.3 µM -3.33346491291662 0.000629874962675922 yes 3347 0.000428857445266207 4798 5412760
SGTC_851 0394-0702 453 µM -3.41121593401127 0.000485533542932206 yes 3348 0.000323369256897465 4793 762646
SGTC_2166 5933061 31.504 µM -3.43984569968067 0.000440594022022408 yes 3349 0.000291022959746142 4775 2877375
SGTC_1211 1056-0033 32.3 µM -3.46142345470097 0.00040930676466698 yes 3350 0.000268663449250095 4805 6741922
SGTC_2526 patulin 37.61 µM -3.53848756395729 0.000313618805005684 yes 3351 0.00020121311846592 4801 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_543 3844-1095 191 µM -3.61459960552143 0.000239904508942749 yes 3352 0.000150406075679757 4799 4230703
SGTC_1713 st033146 12.748 µM -3.85062574799861 0.000101295516600878 yes 3353 5.89082095580401e-05 4798 674619
SGTC_3178 9107506 49.47 µM -4.05500689027058 4.62026336183994e-05 yes 3354 2.50664124986376e-05 4807 8897194
SGTC_690 glyoxal 20.3 µM -4.48730734990365 7.8031028489289e-06 yes 3355 3.60644920131983e-06 4793 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2614 arthonioic acid 13.39 µM -11.7312788927211 2.17543647295584e-29 yes 3356 4.40585699538203e-32 4804 6710684