SGTCid condition conc unit MTD1|YKR080W.score MTD1|YKR080W.strain.pval MTD1|YKR080W.strain.significant MTD1|YKR080W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1250 0485-0349 40.2 µM 7.62060798789121 9.26045735339069e-14 yes 1 1.26241818902473e-14 2 6842794 YDL195W SEC31 SGTC_123 0083-0120 66.675 µM 7.30754056679374 8.5516496380409e-13 yes 2 1.36038099816269e-13 11 16001701 SGTC_1190 1486-1332 13 µM 6.8139109003287 2.3706450757384e-11 yes 3 4.74902721094001e-12 1 4150046 SGTC_47 0149-0135 24.25 µM 6.49075989154818 1.84867736978947e-10 yes 4 4.27022497843406e-11 2 5239155 SGTC_51 1013-0126 23.419 µM 5.38549922028385 1.01094655769309e-07 yes 5 3.61219241095113e-08 18 1627850 SGTC_2635 hydroquinidine 100 µM 4.54640273736403 5.77912493165351e-06 yes 6 2.72852850883225e-06 12 442912 An experimental heart treatment. SGTC_2135 5326629 150.42 µM 4.47579926165398 7.89131990904419e-06 yes 7 3.80629927029695e-06 15 5020077 SGTC_2975 9084847 53.72 µM 3.98628720609446 6.05158503283919e-05 yes 8 3.35576322665464e-05 21 27211724 SGTC_3131 9127911 49.47 µM 3.65242463538717 0.00021486196307419 yes 9 0.000129887924798523 40 45595681 SGTC_2657 nystatin 74.44 µM 3.64256605551618 0.000222719335318615 yes 10 0.000134966839280999 20 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_781 4335-2806 94.4 µM 3.55127424084575 0.000309337689163247 yes 11 0.000191685364660186 31 845254 SGTC_2977 9011197 71.43 µM 3.51508306690802 0.00035165072705829 yes 12 0.000219808228463246 29 2704722 SGTC_2663 amphotericin b 100 µM 3.51497913622672 0.000351779633541023 yes 13 0.000219894269046161 20 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1605 st000082 49.1 µM 3.46849595251769 0.000414044856956285 yes 14 0.000261690205348579 31 1114022 SGTC_2833 9001315 45.46 µM 3.27944366473942 0.000787807327786479 yes 15 0.000520059872101713 86 2989378 SGTC_818 4072-2707 53.5 µM 3.26903836213249 0.000815458668272296 yes 16 0.000539568348004297 33 882871 SGTC_246 cycloheximide 667 µM 3.21504493056881 0.000973832619714764 yes 17 0.000652120531815148 34 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2194 5927483 104.545 µM 3.18075507066956 0.00108858888100325 no 18 0.000734458815616126 44 760979 SGTC_2070 5230947 200 µM 3.17129109207386 0.0011223757100794 no 19 0.000758814912813288 40 2835538 SGTC_3350 9150499 3.57 µM 3.16584736977505 0.00114224267710767 no 20 0.000773159540503372 91 4910996 YPR165W RHO1 SGTC_2319 6033012 152.6 µM 3.15577534811916 0.00117985231123369 no 21 0.000800360492474441 58 847246 SGTC_2097 5376186 200 µM 3.13871930694348 0.00124613526176696 no 22 0.000848439530141784 58 742755 SGTC_3288 9119690 36.221 µM 3.1363420880754 0.00125563935910699 no 23 0.000855347671692599 39 17595618 YKL019W RAM2 SGTC_2893 9048488 25.97 µM 3.11554431069504 0.00134166023937778 no 24 0.000918028805494017 52 6467338 SGTC_2571 chrysanthemic acid 100 µM 3.1013300954163 0.00140351356679471 no 25 0.00096326697937664 56 2743 An insecticide. SGTC_2094 5332512 191.667 µM 3.07801055339892 0.0015106513806532 no 26 0.00104193767558965 64 755774 SGTC_1937 st074714 47.2 µM 3.05934575860268 0.00160172197676234 no 27 0.00110910488820791 77 17250970 SGTC_1534 6-azauridine 81.6 µM 3.05421388291976 0.00162762415014956 no 28 0.00112825571114827 71 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2971 9092186 9.93 µM 3.02878267036366 0.00176170385813152 no 29 0.00122770625198703 67 25236400 SGTC_1640 st009078 66.4 µM 3.00678537428296 0.00188570253571926 no 30 0.0013201305144841 40 690618 SGTC_2729 fluphenazine 10.66 µM 2.9877184381215 0.00199954406041342 no 31 0.00140534180329966 54 3372 An atypical antipsychotic. SGTC_1194 1488-0194 225 µM 2.94628204845805 0.00226874067075014 no 32 0.00160809493126088 83 1391452 SGTC_1002 4049-0206 172 µM 2.91992473404686 0.00245663959702311 no 33 0.00175057966748622 106 4662749 SGTC_2009 4012297 12.05 µM 2.90418757739037 0.00257543090407369 no 34 0.00184103742611639 120 45595307 SGTC_1195 1502-0147 41.1 µM 2.90015320432788 0.00260670864909664 no 35 0.0018649015492162 82 817940 SGTC_2105 5350118 200 µM 2.85391435357664 0.00299049873462102 no 36 0.00215920858825925 81 2133313 SGTC_378 3970-0959 8.33 µM 2.83424926118659 0.00316862147281072 no 37 0.00229667442199807 69 6615653 SGTC_1032 k061-1018 98.7 µM 2.83068148088862 0.0032019425463211 no 38 0.00232244759303575 90 4005393 SGTC_3029 9088683 49.47 µM 2.83067335191029 0.00320201882508185 no 39 0.00232250661352603 76 25236615 SGTC_2801 7907800 81.82 µM 2.82886530820865 0.00321902539355711 no 40 0.0023356677187051 100 6620925 SGTC_2132 5317594 122.667 µM 2.80030774886495 0.00349863408223238 no 41 0.00255269540845904 72 794577 SGTC_261 5-fluorouridine 15.376 µM 2.79295948363514 0.00357402323719825 no 42 0.00261141166098479 80 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1701 st028638 40.4 µM 2.74810440459151 0.00406666350192196 no 43 0.00299704594732196 71 3490878 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 2.73349472442768 0.00423977060558486 no 44 0.0031333063616339 110 91467 include heat shock SGTC_2781 5567276 71.43 µM 2.72595164541521 0.00433170161041232 no 45 0.00320581952890711 138 2853274 SGTC_2968 9090663 33.37 µM 2.71339689107442 0.00448866798407764 no 46 0.00332986449361863 106 25236811 SGTC_3038 9091290 49.47 µM 2.71097380547366 0.00451954100456256 no 47 0.00335429628937158 75 25236843 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.71080359918651 0.00452171674715453 no 48 0.00335601850884672 101 5355888 SGTC_1370 2001-0092 44.6 µM 2.70735389886746 0.00456601620560997 no 49 0.0033910957815015 115 790957 SGTC_62 0180-0423 3.232 µM 2.69755790791611 0.00469393132100231 no 50 0.003492506745239 87 30102 YGL099W LSG1 SGTC_245 methotrexate 289.6 µM 2.68513846417803 0.00486069358860037 no 51 0.00362498819428093 118 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2956 9076196 2.52 µM 2.68422761791749 0.00487312934900468 no 52 0.0036348796793196 92 16423868 SGTC_1709 st033179 39.1045 µM 2.66988005933519 0.00507279222130906 no 53 0.00379391730337186 86 573381 SGTC_817 1391-0715 46 µM 2.65760676986574 0.00524933538567107 no 54 0.00393488289462893 81 1353946 SGTC_2516 gossypol 71.55 µM 2.60843988603943 0.00601260016242159 no 55 0.00454779929904056 90 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1147 3809-1045 12.3 µM 2.59979033652715 0.00615661082119465 no 56 0.0046640366525579 125 325925 SGTC_1267 0828-0272 9.49 µM 2.59371076586767 0.00625965310892132 no 57 0.00474731619716826 94 745334 SGTC_703 3875-0075 71.8 µM 2.55220321418003 0.00700487871674044 no 58 0.00535220319869703 63 2850814 SGTC_2146 5545642 200 µM 2.54464146420161 0.00714877297954139 no 59 0.00546949962264844 86 825326 SGTC_122 0236-0016 402.397 µM 2.52762504994741 0.00748215485507412 no 60 0.00574184601408515 160 6808838 SGTC_3112 9123419 49.47 µM 2.51864758795411 0.00766349924462922 no 61 0.00589032501460088 117 17015854 SGTC_545 4218-0007 221 µM 2.5100007967652 0.00784181086662948 no 62 0.00603654445998781 111 2840508 SGTC_1056 3448-1962 115 µM 2.5088678848683 0.00786544181810262 no 63 0.00605593873445113 101 715507 SGTC_1283 0922-0125 16.4 µM 2.50547082560493 0.00793667563230664 no 64 0.00611442432066168 102 3360884 SGTC_2988 9073640 71.4286 µM 2.48959380999026 0.00827717951330685 no 65 0.00639445815216037 102 9102229 SGTC_1148 3909-7663 27.7 µM 2.46997554723082 0.0087155912027993 no 66 0.00675611441107349 104 4084526 SGTC_2210 7115885 190.385 µM 2.45725320941277 0.00901066467692537 no 67 0.00700019839508934 134 2927039 SGTC_2566 crystal violet carbinol 226 nM 2.45692443110983 0.00901840474706871 no 68 0.00700660803072706 133 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_253 dyclonine 31.25 µM 2.44623624474045 0.00927321715338427 no 69 0.00721781880624487 147 3180 An oral anasthetic. SGTC_961 1252-1571 372 µM 2.44068854750537 0.00940794447135021 no 70 0.007329645669143 134 6813498 SGTC_2332 7982454 138.89 µM 2.40637250669324 0.0102799828146519 no 71 0.0080559133421365 191 2981748 SGTC_1530 rhein 70.4 µM 2.39578243116411 0.0105629614279686 no 72 0.00829246575412309 136 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_3339 9145883 14.936 µM 2.38567325437856 0.0108393968070617 no 73 0.0085239450928666 109 2030670 SGTC_1170 0310-0127 64.8 µM 2.36047890342803 0.0115558948620133 no 74 0.00912567819519563 151 774975 SGTC_2202 7226349 200 µM 2.35767841366057 0.0116380223676689 no 75 0.00919480803674239 96 844334 SGTC_628 1636-0253 16 µM 2.35439939316395 0.0117348269169528 no 76 0.00927633256018345 169 4456143 SGTC_1071 trifluoperazine 6.31 µM 2.35420544267483 0.0117405746275846 no 77 0.0092811743984327 142 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_228 caffeine 993.056 µM 2.35374696199948 0.0117541713892064 no 78 0.00929262884119881 88 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1479 0549-0158 134 µM 2.34296473155012 0.0120778936398951 no 79 0.00956559572252183 168 5440202 SGTC_430 0958-0115 16.4 µM 2.34284176803953 0.0120816295966705 no 80 0.00956874871280943 158 6833180 SGTC_929 2805-0021 398 µM 2.34089786986146 0.0121408236144985 no 81 0.00961871435707169 136 3098024 SGTC_698 k064-0052 127 µM 2.34079377237517 0.0121440005864945 no 82 0.00962139648294923 65 5088751 SGTC_67 0335-0847 266 µM 2.33567674370711 0.0123010590952632 no 83 0.00975404773124443 298 4552207 YOR254C SEC63 SGTC_566 0958-0068 16.5 µM 2.33485627567908 0.0123264049858227 no 84 0.00977546508891548 124 6815365 SGTC_3140 9094243 49.47 µM 2.33044706009839 0.0124633907074275 no 85 0.00989126748336008 166 19291112 SGTC_1557 sumaresinolic acid 42.3 µM 2.32618184611761 0.0125971550080094 no 86 0.0100044258544624 150 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_938 3126-1755 342 µM 2.31026999553368 0.0131072010899652 no 87 0.0104366054927591 134 1777771 SGTC_1907 st060210 83.7 µM 2.30854173839758 0.0131636595121792 no 88 0.0104845120802474 164 688793 SGTC_275 trichlorophene 5.69 µM 2.29571268247772 0.0135893647013756 no 89 0.0108461574093093 384 62616 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.29012013693862 0.0137786286465574 no 90 0.011007176674973 140 16486 A toxic proline analog. SGTC_1387 3342-1166 1.8 µM 2.28291404695886 0.014025847361722 no 91 0.0112177159440505 93 3418228 SGTC_2128 5255449 168.493 µM 2.28019616829298 0.0141200773717786 no 92 0.0112980282500389 189 736008 SGTC_1871 st057448 67.3 µM 2.26026121395844 0.0148280512683842 no 93 0.0119025218369712 173 691747 SGTC_300 r073-0011 5.04 µM 2.23445590306428 0.0157896724818297 no 94 0.0127265454642337 171 2735780 SGTC_95 0471-0001 561.058 µM 2.21614800197027 0.016503914474166 no 95 0.0133406838379037 175 4015405 SGTC_2974 9094440 9.66 µM 2.21483688577186 0.0165561095249013 no 96 0.0133856312180538 195 25236134 SGTC_1613 st002381 52.1 µM 2.21407753756479 0.0165864034552193 no 97 0.013411722771324 159 551167 SGTC_510 ag-490 170 µM 2.20717581132306 0.0168639270395876 no 98 0.0136508894893182 93 5328779 SGTC_2145 5634607 200 µM 2.20208957606307 0.0170709813565508 no 99 0.013829490829494 121 308662 SGTC_3235 9132602 49.47 µM 2.1972309965935 0.017270793381147 no 100 0.0140019764612057 185 4912240 SGTC_2088 5278280 127.392 µM 2.19681464848394 0.017288008512852 no 101 0.014016843231863 206 791502 SGTC_2751 anetholtrithion 17.25 µM 2.17467753620782 0.0182246818892892 no 102 0.0148271447092857 184 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1442 4112-3290 3 µM 2.17372228626614 0.01826605575074 no 103 0.0148629989556013 173 704353 SGTC_2449 5812982 45.77 µM 2.16219109068588 0.0187718425364352 no 104 0.0153017249963872 127 776185 SGTC_6 0844-0013 19.835 µM 2.15144891343056 0.0192536952076154 no 105 0.0157203919886339 411 1584900 SGTC_3070 9117005 49.47 µM 2.14228921699221 0.0196728288574902 no 106 0.0160851080033785 105 8779016 SGTC_1280 0880-0253 10.1 µM 2.14102624252925 0.0197312239211458 no 107 0.0161359609308849 188 6836607 SGTC_2939 9044578 71.43 µM 2.13628732332187 0.0199516468539388 no 108 0.016328000754795 209 2653634 SGTC_1848 st056003 16.4 µM 2.11849194938323 0.0207981136177463 no 109 0.0170667130040503 171 146492 SGTC_1727 st034309 9.9045 µM 2.11827102809829 0.0208088102963655 no 110 0.0170760604006809 263 870305 SGTC_1735 st034310 56.75 µM 2.1148082596038 0.0209770819821672 no 111 0.0172231463145803 190 871153 SGTC_753 1322-0200 289 µM 2.09938153712055 0.0217407960277825 no 112 0.0178916404548918 182 5403907 SGTC_840 0245-0196 390 µM 2.09822887752588 0.0217987907003239 no 113 0.01794246590667 205 3827528 SGTC_128 0906-2981 13.371 µM 2.09296749319958 0.0220651730250939 no 114 0.0181760282303712 147 6740226 SGTC_897 1000-0139 31.4 µM 2.08186121791743 0.0226365109980107 no 115 0.0186775740377838 166 6151020 SGTC_2864 9034755 47.6 µM 2.0711908914152 0.0231971185766549 no 116 0.0191704802389234 199 4930451 SGTC_2791 5663188 71.43 µM 2.06880362376171 0.023324130526016 no 117 0.0192822591233065 201 54690634 SGTC_965 1291-5240 308 µM 2.06456596501204 0.023551032112877 no 118 0.0194820431884073 213 2834598 SGTC_1775 st081588 35.1725 µM 2.06055162683084 0.0237676859264563 no 119 0.0196729178584192 225 1426443 YGL099W LSG1 SGTC_1821 st053465 65.6 µM 2.05992581954015 0.0238016112527951 no 120 0.0197028164747525 163 675086 SGTC_2245 6637752 200 µM 2.0505714965361 0.0243135849431463 no 121 0.0201543472655115 137 681890 SGTC_3147 9097027 49.47 µM 2.04876069328166 0.0244137532795941 no 122 0.0202427605439229 215 25236841 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 2.02936990396258 0.0255082792027734 no 123 0.0212103140690528 198 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_229 benomyl 22.8748 µM 2.02085588655665 0.0260016822101391 no 124 0.0216473427850527 216 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1670 st016595 4.04 µM 2.02048204290986 0.026023528846209 no 125 0.0216667054670565 205 597879 SGTC_1389 3405-0187 19 µM 2.01750048000334 0.0261983152184015 no 126 0.0218216554937729 203 799890 SGTC_3349 9149703 23.001 µM 2.01024247536441 0.0266279034154806 no 127 0.0222027659469293 185 4910494 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.00356409995673 0.0270283671637461 no 128 0.022558387362206 282 688664 SGTC_2399 5884133 200 µM 1.99941369402958 0.0272797665247397 no 129 0.0227818057392841 273 722445 SGTC_2200 6600604 21.907 µM 1.99752661925382 0.0273947142331533 no 130 0.0228840028696642 252 2904777 SGTC_1187 1391-0724 117 µM 1.99686988292251 0.027434812750866 no 131 0.0229196598064849 222 6997986 SGTC_43 0570-0105 72.5 µM 1.99653116524452 0.0274555130455055 no 132 0.0229380684800279 387 1114046 YDL195W SEC31 SGTC_1904 st060225 78 µM 1.99641760720566 0.0274624559130957 no 133 0.022944242934554 189 66595 SGTC_1838 st055369 84.5 µM 1.99500442902233 0.0275489792740501 no 134 0.0230211984057702 198 676036 SGTC_1005 4092-0690 4.4 µM 1.98685056073471 0.0280526581869741 no 135 0.023469479851554 224 1529343 SGTC_514 4466-0038 2.65 nM 1.98214081166204 0.0283470656139976 no 136 0.023731741464507 395 5722064 SGTC_1994 st072947 40.9 µM 1.97868959756896 0.028564430401209 no 137 0.0239254824391742 230 5286565 YDL195W SEC31 SGTC_379 3970-0972 5.9 µM 1.97734348236784 0.0286495865944409 no 138 0.0240014088858532 239 2898042 YBL034C STU1 SGTC_2003 4023581 200 µM 1.96828762406383 0.0292279703605847 no 139 0.0245174765551533 245 16641307 SGTC_166 k072-0058 166.424 µM 1.96503999466776 0.0294377401725232 no 140 0.024704804360153 255 5846229 SGTC_2848 9016370 25.97 µM 1.96492188304681 0.0294453926947462 no 141 0.0247116397707495 252 7894410 SGTC_2700 st077718 96.8 µM 1.96120292892752 0.029687191952882 no 142 0.0249276776725028 169 904970 SGTC_2927 9011802 47.9 µM 1.95452866616061 0.0301252711642491 no 143 0.0253193640707498 240 43912568 SGTC_2715 st079500 56.4 µM 1.93978065457652 0.0311123116118599 no 144 0.0262031763383177 198 28246688 SGTC_1526 st051518 75 µM 1.9323368211533 0.0316205766940124 no 145 0.0266589732467189 232 673993 SGTC_2774 tamoxifen 10.92 µM 1.93043333139632 0.0317516430213277 no 146 0.0267765841701194 216 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.92821955675968 0.0319046384928467 no 147 0.0269139113257961 238 521171 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.92111487679448 0.0323997655670665 no 148 0.0273586132403402 239 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_50 0929-0078 56.389 µM 1.90641754937209 0.0334441593011018 no 149 0.0282980268106598 271 1377751 SGTC_1097 itavastatin 7.23 µM 1.90138345133847 0.0338081942511467 no 150 0.0286259027590085 267 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1966 st070145 16.1 µM 1.89688410701424 0.0341363120933296 no 151 0.028921617734379 241 3748532 SGTC_2654 protoveratrine a 100 µM 1.89351249999008 0.0343839011942353 no 152 0.0291448737491058 223 5702278 A heart drug and vasodilator. SGTC_508 roscovitine 141 µM 1.89330764457877 0.0343989918862007 no 153 0.0291584845687699 189 160355 A CDKinase inhibitor. SGTC_324 1315-0088 19.6 µM 1.88996474329965 0.0346460169528069 no 154 0.0293813377729664 190 6787421 SGTC_2231 micatex 6.853 µM 1.88723976470666 0.0348484565799464 no 155 0.0295640420503791 192 20737 An antifungal of unknown mechanism. SGTC_621 3584-0052 32.1 µM 1.88334570776922 0.0351394319019085 no 156 0.0298267664408382 261 2273927 SGTC_1144 3486-0183 12.5 µM 1.87930798605993 0.0354432443487481 no 157 0.0301012259432534 285 6744069 SGTC_264 promethazine 12.5 mM 1.87611014139597 0.0356853870304319 no 158 0.0303200787083792 375 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2374 9071832 200 µM 1.87083202393927 0.0360880137211955 no 159 0.0306841836773069 223 17381698 SGTC_867 0518-0118 155 µM 1.86804204168677 0.0363023382414115 no 160 0.0308781055538634 259 6848158 SGTC_679 0422-0091 41.4 µM 1.86669833541934 0.0364059319663379 no 161 0.0309718631689869 313 627384 YHR062C RPP1 SGTC_2821 7996764 71.43 µM 1.8661987002573 0.0364445132480205 no 162 0.0310067854347724 313 2987135 SGTC_2761 levamisole 97.89 µM 1.86221748871779 0.0367531349979301 no 163 0.0312862201394629 244 26879 An alkaline phosphatase inhibitor. SGTC_1435 4092-0789 56.7 µM 1.86032020003602 0.0369009622113595 no 164 0.0314201186484422 239 2248285 SGTC_469 w7 172 µM 1.85881616743736 0.0370184940083642 no 165 0.0315266000101511 164 45115570 A P450 inhibitor. SGTC_1711 st032263 62.8 µM 1.85392468603186 0.0374028535615043 no 166 0.0318749678063494 241 3958979 SGTC_2216 7189485 200 µM 1.85241761112573 0.0375219302203775 no 167 0.0319829391599019 187 731273 SGTC_930 2810-3379 265 µM 1.84746333535387 0.0379155595137466 no 168 0.0323400086245858 297 1015764 SGTC_770 0389-1121 67.2 µM 1.84362171873819 0.0382230991647529 no 169 0.0326191442810084 325 6753108 SGTC_1857 st056007 79.3 µM 1.84296850220624 0.0382755940454915 no 170 0.0326668047230835 211 619834 SGTC_806 3966-4455 5.86 µM 1.8411970177973 0.0384182529766131 no 171 0.0327963461145892 237 714982 SGTC_2217 6934799 96.0675 µM 1.83931098507259 0.0385706126289306 no 172 0.032934729119678 218 675606 SGTC_661 1304-0007 33.6 µM 1.83752495036761 0.0387153476977228 no 173 0.0330662183124518 251 3117130 SGTC_2675 theaflavin digallate 100 µM 1.83499021849637 0.0389215142547016 no 174 0.0332535693912217 276 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_160 3453-0671 289.699 µM 1.83444895196322 0.0389656546903285 no 175 0.0332936894064456 295 5322268 SGTC_2936 9038235 15.59 µM 1.83381768990222 0.0390171857684196 no 176 0.0333405304619862 271 4749415 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.83376150663068 0.0390217747994318 no 177 0.0333447020149297 254 2374 Ca(2+)-ATPase inhibitor. SGTC_3336 9143619 71.43 µM 1.82724100620034 0.0395573595340517 no 178 0.033831770437558 289 45595730 SGTC_116 0155-0182 31.788 µM 1.82632010678595 0.0396334804855384 no 179 0.0339010291373131 424 771486 SGTC_1992 st073643 23.3 µM 1.82449137882927 0.0397849950989521 no 180 0.0340389092594294 230 3161292 SGTC_635 k038-0028 24.7 µM 1.82323594105582 0.0398892835553551 no 181 0.0341338318675998 299 4035102 SGTC_499 genistein 192 µM 1.82278029893052 0.0399271883832135 no 182 0.0341683363718182 173 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2136 5328288 199.296 µM 1.81776262450763 0.0403465475452593 no 183 0.034550210726263 237 262395 SGTC_1841 st054148 70 µM 1.81741538206992 0.0403757006561612 no 184 0.0345767671001422 257 675442 SGTC_89 0302-0250 142.109 µM 1.81611531874905 0.0404850008081041 no 185 0.0346763421580104 297 4203518 YLR208W SEC13 SGTC_2002 4023503 131 µM 1.80828972141357 0.041148006659324 no 186 0.0352807103837087 384 4736863 YCR052W RSC6 SGTC_2071 5230951 39.92 µM 1.80693843318372 0.0412633779089446 no 187 0.035385939599022 288 1799272 SGTC_1926 methyl fluorone black 53.6 µM 1.7992379066009 0.0419258532186977 no 188 0.0359905277883279 297 72721 Reacts with homocysteine. SGTC_1664 st014217 9.02 µM 1.78622127408077 0.0430652312138462 no 189 0.0370317189111379 292 3982782 SGTC_2596 sinensetin 100 µM 1.78273594743071 0.0433745193234729 no 190 0.0373146483871943 286 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1960 st011366 51.8 µM 1.7795077638489 0.0436625859794691 no 191 0.0375782765872057 235 3972846 SGTC_1395 3486-0190 4.35 µM 1.77625585781417 0.043954328368388 no 192 0.0378453776576907 291 6748079 SGTC_1240 0356-0016 42.1 µM 1.77512540183518 0.0440561138973659 no 193 0.0379385917883356 305 4305613 SGTC_619 1652-1634 108 µM 1.77133701463503 0.0443986042280059 no 194 0.0382523378559366 261 5400454 SGTC_947 3447-0010 211 µM 1.77096349595807 0.0444324881782582 no 195 0.0382833861192342 276 748350 SGTC_2441 5730946 39.09 µM 1.75588646863824 0.0458176931809692 no 196 0.0395538979427635 312 1774275 SGTC_3233 9132340 49.47 µM 1.75579079149871 0.0458265931003695 no 197 0.0395620686560755 283 17682950 SGTC_1990 st072050 59.8 µM 1.75432185708921 0.0459634083525945 no 198 0.0396876863134716 275 17233948 SGTC_237 nikkomycin 200 µM 1.7486805930445 0.0464918835531903 no 199 0.0401731232467326 312 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_530 4358-1714 28 µM 1.74340170199624 0.0469908181709539 no 200 0.0406317356091845 366 1564641 SGTC_944 3370-0224 231 µM 1.74074859199309 0.0472431933016757 no 201 0.0408638283349099 302 4580514 SGTC_528 3492-0019 172 µM 1.73477569218285 0.0478153372920673 no 202 0.0413902716471854 570 2869262 SGTC_1085 doxorubicin 7.67 µM 1.7344224356093 0.0478493487402545 no 203 0.0414215785669282 352 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_202 3594-0513 34.79 µM 1.7325781813119 0.0480272276817744 no 204 0.041585335037906 250 708429 SGTC_98 0074-0023 107.663 µM 1.7204953097421 0.0492057528998032 no 205 0.0426712227574034 342 3563821 SGTC_1377 2944-0135 198 µM 1.71953751371717 0.0493001526774021 no 206 0.0427582714938662 348 1894137 SGTC_892 0929-0076 29 µM 1.71327834587664 0.0499206175024903 no 207 0.0433306720820146 386 5751038 SGTC_718 1130-0073 349 µM 1.71037351397473 0.0502106785718814 no 208 0.043598412772907 343 6740020 SGTC_121 0557-0495 61.343 µM 1.69444898212032 0.051824762753807 no 209 0.0450899992432845 491 3104427 SGTC_2285 7945142 200 µM 1.69343902661875 0.0519285049505343 no 210 0.0451859658181443 321 2970608 SGTC_349 k015-0014 24 µM 1.69342890024674 0.0519295459620778 no 211 0.0451869288635512 308 2196908 SGTC_2534 helenine 20.12 µM 1.6934155753122 0.0519309158175921 no 212 0.0451881961260823 274 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_157 1348-1695 65.819 µM 1.69238352355895 0.0520371020491629 no 213 0.0452864359036914 420 5380510 SGTC_1078 idebenone 36.1 µM 1.6907666879868 0.0522038025104884 no 214 0.0454406859044548 395 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_281 1672-3440 14.9 µM 1.68610122224944 0.0526872040494267 no 215 0.0458881523172918 330 6833000 SGTC_1634 st006576 41 µM 1.6840997981114 0.0528956627058117 no 216 0.046081191692416 321 3915356 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 1.68323907581607 0.0529855123089995 no 217 0.0461644095577194 357 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2242 6630449 61.2675 µM 1.68322293514263 0.0529871983669006 no 218 0.0461659712508067 309 691249 YDR170C SEC7 SGTC_32 0928-0142 34.1 µM 1.68212865692181 0.0531016061467934 no 219 0.0462719472776558 275 2244242 SGTC_1183 1254-0324 198 µM 1.68027622020563 0.05329572642746 no 220 0.0464517927694778 317 5799357 SGTC_257 daunorubicin 18.5 µM 1.67849171665838 0.0534832593611015 no 221 0.0466255730911345 276 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_659 k018-0002 107 µM 1.6759682629217 0.0537493403537121 no 222 0.0468722046358604 336 6797879 YHR007C ERG11 SGTC_2889 9059656 51.95 µM 1.67515801218382 0.0538349977729032 no 223 0.0469516166251116 336 3949838 SGTC_3192 9110362 49.47 µM 1.66810419339708 0.0545852818042285 no 224 0.0476475224456918 325 16649480 SGTC_2636 apigenin dimethyl ether 100 µM 1.66750835762347 0.054649035123587 no 225 0.0477066819753985 397 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_282 k297-0036 65.7 µM 1.66748200275441 0.0546518564046363 no 226 0.0477093000637666 286 5061378 SGTC_1130 3454-2858 15.9 µM 1.66739901332402 0.0546607411512413 no 227 0.0477175449717724 384 715628 YIL048W NEO1 SGTC_2643 anethole 100 µM 1.64659857167195 0.0569238583730522 no 228 0.0498202921203242 370 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1131 3454-3128 32.3 µM 1.64491219131013 0.0571105255219602 no 229 0.0499939602182801 411 710982 SGTC_2614 arthonioic acid 13.39 µM 1.64388321401776 0.0572246605503614 no 230 0.0501001640626649 318 6710684 SGTC_75 0159-0059 199.013 µM 1.63803886453251 0.0578763296355834 no 231 0.0507067933548191 336 5377270 SGTC_574 1315-0397 40 µM 1.63460163886046 0.0582623102980864 no 232 0.0510662919407936 446 6794277 SGTC_2425 5628681 7.85 µM 1.63337095809088 0.0584009992528949 no 233 0.0511955006149893 418 5714958 SGTC_893 0958-0369 48.9 µM 1.63152638491847 0.058609354880042 no 234 0.0513896485766083 396 6819948 SGTC_213 1246-0773 967 nM 1.63029558672239 0.0587487052312546 no 235 0.0515195199373157 375 6251622 SGTC_92 0063-0024 660.874 µM 1.62406696308235 0.0594578985987189 no 236 0.0521807589337184 382 3594437 SGTC_1963 st076565 50.3 µM 1.62312848677863 0.059565333171096 no 237 0.0522809705734864 351 4914280 SGTC_901 1112-0062 60.1 µM 1.61885435488624 0.0600565512025808 no 238 0.0527393019294342 335 1908457 SGTC_837 0091-0265 12.5 µM 1.61768507112709 0.060191485907695 no 239 0.0528652424574518 375 759367 SGTC_3134 9127454 49.47 µM 1.61313007177721 0.0607193945630776 no 240 0.0533581258965597 329 24262820 SGTC_662 k832-1615 104 µM 1.61087668635484 0.0609818895030854 no 241 0.0536033011694903 350 5878478 SGTC_1354 1498-1681 81 µM 1.6074870384767 0.0613784165334674 no 242 0.0539737852287214 394 5754243 SGTC_1518 st038567 90.8 µM 1.60731863420428 0.0613981691614062 no 243 0.0539922443200065 315 77966 SGTC_1205 4161-2785 76 µM 1.60704275770404 0.0614305382500425 no 244 0.0540224944317887 341 3498106 SGTC_293 4049-0273 38.5 µM 1.60247436371927 0.0619684963530463 no 245 0.0545253760616018 319 1380311 SGTC_1343 1487-0095 224 µM 1.60070668166223 0.0621776361932827 no 246 0.0547209502845528 341 4560101 YGL055W OLE1 SGTC_2647 atorvastatin 60.16 µM 1.60035876642761 0.0622188638784976 no 247 0.0547595084482149 360 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_256 clotrimazole 625 nM 1.60001321197204 0.0622598329167495 no 248 0.0547978262320813 376 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_377 3970-0964 33.1 µM 1.59844157391974 0.0624464323158718 no 249 0.0549723692443241 476 16481235 SGTC_1368 1852-0141 284 µM 1.59635614915553 0.062694706066252 no 250 0.0552046502857243 380 2838987 SGTC_20 0481-0013 4.944 µM 1.59501458437458 0.0628548280720139 no 251 0.0553544872272806 385 182045 SGTC_1692 fluoroquinolonic acid 71 µM 1.58765132756981 0.0637393472152567 no 252 0.0561826024102298 320 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_247 mechlorethamine 29.705 µM 1.58170549762646 0.0644606381495548 no 253 0.0568584085504862 296 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1492 4158-0558 28.5 µM 1.5815735816693 0.0644767125376896 no 254 0.0568734744621008 357 3967268 SGTC_2694 st077685 81.9 µM 1.58075347741157 0.0645767147775949 no 255 0.0569672078010334 381 2838096 SGTC_1747 st037496 66.6 µM 1.58003985451273 0.0646638308392127 no 256 0.0570488698484159 415 723305 SGTC_2652 actinonin 100 µM 1.57951337279753 0.0647281599858363 no 257 0.0571091758128525 302 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1707 st032323 6.317 µM 1.57449023142606 0.0653444234392728 no 258 0.0576870790681598 404 3132057 YMR211W DML1 SGTC_1340 1486-1359 257 µM 1.5709439071903 0.065782237751522 no 259 0.05809783930066 365 4309068 SGTC_1438 4092-1045 4 µM 1.56946474046376 0.0659655200524744 no 260 0.0582698445467224 374 1351342 SGTC_1746 st038117 42 µM 1.56261961358755 0.0668188508185236 no 261 0.0590710460864409 401 2898218 SGTC_1358 1509-0022 2.48 µM 1.55423443892741 0.0678757778623896 no 262 0.0600642527455841 392 3258434 SGTC_636 0kpi-0074 126 µM 1.54894760691828 0.0685487749863132 no 263 0.0606971576849542 367 616434 SGTC_1864 st057645 30.4 µM 1.53509554048769 0.070336509566932 no 264 0.0623801807801555 341 688666 SGTC_3088 9117578 49.47 µM 1.53482529889649 0.0703717398608775 no 265 0.0624133733505328 362 678341 SGTC_2356 9061756 188.97 µM 1.53382759027021 0.0705019245875724 no 266 0.0625360367457514 357 20104043 SGTC_1333 1482-0047 286 µM 1.53289004769291 0.0706244272758175 no 267 0.0626514742223235 434 3811116 SGTC_2552 juarezic acid 87.02 µM 1.5327736439989 0.0706396484112046 no 268 0.0626658183265711 481 1549512 SGTC_906 1165-0455 526 µM 1.52436233372104 0.071746211938561 no 269 0.0637091119142488 374 3252859 SGTC_2560 caryophyllene 100 µM 1.52033823969711 0.0722802880738626 no 270 0.0642129939755566 457 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2116 5511452 16.8835 µM 1.52005303308874 0.0723182558895461 no 271 0.0642488237037067 424 870744 SGTC_2113 5491891 107.031 µM 1.5195009752401 0.0723917914011462 no 272 0.0643182213707792 433 789979 SGTC_1949 st076024 69.1 µM 1.51939780811275 0.0724055398765529 no 273 0.0643311966832249 436 2921930 SGTC_580 1123-0028 41 µM 1.51603292618534 0.0728550554050043 no 274 0.0647555134496447 470 1677248 YPR107C YTH1 SGTC_44 0929-0055 61.211 µM 1.51579645109551 0.0728867263494373 no 275 0.0647854148607118 379 1379590 SGTC_170 4197-0004 226 µM 1.51241721916814 0.0733404567202849 no 276 0.0652138785733861 353 218692 SGTC_3005 9076496 71.4286 µM 1.5108123102218 0.0735567035576374 no 277 0.0654181386993799 371 21368410 SGTC_2892 9047358 58.44 µM 1.50765789951653 0.0739831519882289 no 278 0.0658210529138607 336 6466771 SGTC_1096 rimcazole 32.2 µM 1.50719237758715 0.0740462460730304 no 279 0.0658806767487883 372 18528119 A dopamine reuptake inhibitor. SGTC_2098 5376439 882.5 nM 1.50642136237805 0.0741508353196851 no 280 0.0659795200842258 444 2844116 SGTC_1679 SEC14.276 6.7 µM 1.50588724684766 0.0742233549427073 no 281 0.0660480604773292 487 1005053 YMR079W SEC14 SGTC_447 ml7 120 µM 1.50297878094535 0.0746192032777594 no 282 0.0664222579295602 419 4216 Selective myosin light chain kinase inhibitor. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.50063661110655 0.0749391470966772 no 283 0.0667247882895569 375 279621 SGTC_1328 1441-0025 69.2 µM 1.49933727866578 0.0751170884998302 no 284 0.0668930780135689 367 4562601 SGTC_1698 5-fluorocytosine 1.055 µM 1.49775785781066 0.0753338211819336 no 285 0.0670980867716488 386 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.49553579394382 0.075639545805314 no 286 0.0673873327822985 453 1377 SGTC_1485 3909-9022 254 µM 1.49484191357553 0.0757352073629705 no 287 0.0674778523643031 426 714516 SGTC_524 r073-0010 27.8 µM 1.49481693442536 0.0757386528218759 no 288 0.0674811127498264 410 2772106 SGTC_2900 5328528 85.29 µM 1.49426902001815 0.0758142585505547 no 289 0.0675526595089977 484 795359 SGTC_2163 5671233 125 µM 1.49269327498593 0.0760320131562761 no 290 0.0677587472696944 458 701023 SGTC_691 1548-0686 185 µM 1.49202453206269 0.0761245715538373 no 291 0.0678463571392081 458 46495133 SGTC_3121 9125696 49.47 µM 1.48403597004911 0.0772368823118518 no 292 0.0688996891167307 362 1235365 SGTC_3053 9095903 49.47 µM 1.46836005717845 0.0794553904186788 no 293 0.0710032226685228 397 17174018 SGTC_2258 7960471 200 µM 1.46540011701044 0.079879651106594 no 294 0.0714058927723898 337 2974708 SGTC_1207 2099-0101 141 µM 1.4622895877924 0.0803273401832029 no 295 0.0718309352914804 490 5837381 SGTC_940 3232-1287 54.8 µM 1.44859356995475 0.0823211424355051 no 296 0.0737255589737696 445 1585493 YIL048W NEO1 SGTC_2321 7390090 138.78 µM 1.44836625010315 0.0823545461804129 no 297 0.0737573242105197 400 649046 SGTC_1725 st036284 20.55 µM 1.44781608012108 0.0824354337061233 no 298 0.0738342471979556 505 707914 SGTC_1763 st044482 94.5 µM 1.44316625606954 0.0831214544105594 no 299 0.0744868213326982 470 88505 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.44147937416213 0.0833713901837648 no 300 0.0747246501409851 725 16725076 SGTC_3195 9113082 49.47 µM 1.43997681555581 0.0835944911281554 no 301 0.0749369792597432 414 17018038 SGTC_605 1315-0399 119 µM 1.43955271687602 0.0836575426979486 no 302 0.0749969925683245 497 24020461 SGTC_752 1896-0090 130 µM 1.4380716812403 0.083878011394025 no 303 0.0752068583451586 453 772567 SGTC_1264 0783-0040 158 µM 1.43782266893774 0.0839151224678133 no 304 0.0752421878248268 427 2855798 SGTC_136 0097-0015 404.482 µM 1.43596784608837 0.0841919405360202 no 305 0.0755057454671161 500 4861337 SGTC_1554 st069299 38.7 µM 1.43338710078137 0.0845782364988033 no 306 0.0758736213288338 463 24207999 SGTC_1778 st046819 58.9 µM 1.42989423127906 0.085103178114823 no 307 0.0763736889773818 531 671715 SGTC_1638 st008370 60.6 µM 1.4281046934264 0.0853730710130387 no 308 0.0766308634038171 486 24207134 SGTC_1310 1188-0297 994 nM 1.42256594448858 0.0862124720710248 no 309 0.0774310110996402 473 1588352 SGTC_117 lucigenin 22.078 µM 1.42225253392713 0.0862601535339709 no 310 0.0774764764942255 533 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2191 5911152 200 µM 1.41901083047853 0.0867544953917452 no 311 0.0779479292752401 449 2875902 SGTC_1921 5740136 50 µM 1.4166642381516 0.0871136564886768 no 312 0.0782905587253606 512 1774243 SGTC_525 k781-2675 26.7 µM 1.4122788270948 0.087787846814601 no 313 0.0789339390618035 497 3651118 YDL195W SEC31 SGTC_2043 5101342 149 µM 1.40931148134352 0.0882462339292389 no 314 0.0793715426681784 483 678451 SGTC_1805 st050013 60.3 µM 1.40928326311627 0.0882506015472586 no 315 0.0793757128934256 424 4037144 SGTC_785 1270-0111 65.3 µM 1.40856404310185 0.0883619768349871 no 316 0.0794820586743639 480 6741994 SGTC_1068 loratadine 26.9 µM 1.40474691871732 0.088954833779849 no 317 0.0800482742487516 461 3957 A H1 histamine antagonist. SGTC_176 1486-1328 72.834 µM 1.4035115036813 0.0891473452202925 no 318 0.080232182015061 517 22310231 SGTC_2067 5224629 34.075 µM 1.40341209066993 0.08916284995328 no 319 0.0802469948193783 490 2835000 SGTC_1943 st076331 65.2 µM 1.40025318815965 0.0896565668024912 no 320 0.0807187567306248 484 24208415 SGTC_106 0092-0003 11.579 µM 1.39721798212538 0.0901328627154416 no 321 0.0811740154187127 388 1072148 SGTC_2875 9039966 71.43 µM 1.39469029663539 0.0905309490695558 no 322 0.0815546261220148 416 6463691 SGTC_2776 terbinafine 19.92 µM 1.39243038011029 0.0908879682416308 no 323 0.0818960550754442 479 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1249 0481-0015 10.2 µM 1.39042342769249 0.0912058992314067 no 324 0.0822001682296207 414 4227577 SGTC_233 rapamycin 362 pM 1.39020006145526 0.0912413346875378 no 325 0.0822340674100826 482 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_696 1560-0013 611 µM 1.38762391941314 0.0916507592419735 no 326 0.0826257969652468 499 1650269 SGTC_1225 1216-0074 20.6 µM 1.38673509133079 0.091792335491922 no 327 0.082761278023734 472 4241466 SGTC_3248 9135562 49.47 µM 1.38382168705552 0.0922575304534412 no 328 0.0832065303801469 510 17650701 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.3830937126673 0.0923740410631276 no 329 0.083318066641269 470 75037 A free radical scavenger. SGTC_1440 4100-1550 40 µM 1.38166031428434 0.09260377135567 no 330 0.083538012591749 423 742806 SGTC_2423 st077119 87.2 µM 1.37792740113951 0.0932040271093179 no 331 0.0841128519693482 490 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.37780187929861 0.0932242609801529 no 332 0.0841322328250334 422 6857784 SGTC_796 1234-0020 70.7 µM 1.37399290883806 0.0938398040211707 no 333 0.0847219419450786 508 46495034 SGTC_2992 9074591 71.4286 µM 1.37225800330051 0.0941211631830821 no 334 0.0849915672038546 473 17741321 SGTC_2842 9000675 19.48 µM 1.37088605353147 0.0943441001261876 no 335 0.0852052397783199 472 2989072 SGTC_2465 5809242 33.21 µM 1.36998555290074 0.0944906398055804 no 336 0.0853457057431365 449 2731748 SGTC_1614 st002383 48.6 µM 1.36851849872844 0.0947297347979964 no 337 0.0855749178245954 513 1947235 SGTC_3187 9109394 49.47 µM 1.36038560921124 0.0960632940381059 no 338 0.0868539650076486 529 17098090 SGTC_12 0849-0099 9.267 µM 1.3585319306945 0.0963691661806511 no 339 0.0871474788631217 477 6071388 SGTC_689 0833-0039 98 µM 1.35787747633396 0.0964773272829419 no 340 0.0872512827405331 516 5374726 SGTC_757 1066-0008 322 µM 1.35510827677525 0.0969359777219226 no 341 0.0876915310302582 536 6842497 SGTC_1745 st081495 74 µM 1.35484454490509 0.0969797418254462 no 342 0.0877335454915696 571 13842402 YBL026W LSM2 SGTC_197 4544-0043 41.561 µM 1.35340456047108 0.0972189510514732 no 343 0.0879632106624628 553 896523 SGTC_995 3931-2021 34.6 µM 1.35105916895474 0.0976094923006838 no 344 0.0883382398189553 489 730143 SGTC_3103 9120822 49.47 µM 1.3500420482658 0.0977792146184759 no 345 0.0885012477880305 538 17141819 SGTC_472 calcifediol 10 µM 1.34967651621915 0.0978402621077158 no 346 0.0885598841716461 427 5283731 A vitamin D metabolite. SGTC_927 2425-1185 123 µM 1.34761662538199 0.0981848067630436 no 347 0.088890860247311 488 730375 SGTC_2110 5483698 200 µM 1.34388641951958 0.098810994853522 no 348 0.0894925590901276 496 2848765 YHR062C RPP1 SGTC_1478 0453-0656 35.7 µM 1.34319810854972 0.0989268599933488 no 349 0.089603916986041 517 5258496 SGTC_1282 0886-0010 32.4 µM 1.33654622369806 0.100051714021192 no 350 0.0906854013115687 591 2836211 YNL267W PIK1 SGTC_1667 st014849 34.6 µM 1.33571819476793 0.100192387249722 no 351 0.0908207000136863 536 5348460 SGTC_210 3551-0445 56.827 µM 1.33213034609381 0.100803592529643 no 352 0.0914086800243929 525 2865180 YOR207C RET1 SGTC_2528 xanthyletin 44.79 µM 1.32769793353115 0.101562421419171 no 353 0.092138958253817 493 65188 An natural product with antifungal activity of unknown mechanism. SGTC_690 glyoxal 20.3 µM 1.32114625774552 0.1026916740027 no 354 0.093226300849446 555 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_345 1362-0200 395 µM 1.320552562108 0.102794453068616 no 355 0.0933252995465188 504 1419823 SGTC_3143 9086658 49.47 µM 1.31898599684314 0.10306601163137 no 356 0.0935868969880628 611 25236626 SGTC_2922 7999257 32.47 µM 1.31895751027791 0.103070954496014 no 357 0.0935916589073763 483 2988377 SGTC_1880 MG-132 525 µM 1.31558688804711 0.10365702622073 no 358 0.0941563684053305 487 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2267 7931562 200 µM 1.31556266477157 0.10366124680994 no 359 0.0941604358173941 481 934880 SGTC_1265 0819-1001 68.8 µM 1.31174704709399 0.104327625908221 no 360 0.0948027484841421 512 3106768 SGTC_1053 3366-3204 134 µM 1.31097570137429 0.104462714090012 no 361 0.0949329865218058 572 3632071 YPR165W RHO1 SGTC_765 1319-0117 244 µM 1.3104296934479 0.1045584147396 no 362 0.0950252569948253 495 3487746 YGL099W LSG1 SGTC_2884 9058502 51.95 µM 1.3099177347393 0.104648205148615 no 363 0.0951118334474193 553 6471554 SGTC_551 k048-0028 34.9 µM 1.30942920241399 0.104733938960057 no 364 0.0951945024586412 585 6836383 SGTC_807 1315-0151 48 µM 1.30896812021358 0.104814902126459 no 365 0.0952725749086412 614 4011080 SGTC_3023 9089636 49.47 µM 1.30407604007042 0.105676713470745 no 366 0.0961038286376801 561 17249241 SGTC_1397 3532-0190 20.1 µM 1.30402241271951 0.105686189015582 no 367 0.0961129703571231 452 5322280 SGTC_1391 3442-0225 151 µM 1.30226541277106 0.10599697736298 no 368 0.096412835421117 488 5227075 SGTC_2144 5628481 200 µM 1.30208453018472 0.106029010379179 no 369 0.0964437454214235 485 2818399 SGTC_460 trequinsin 123 µM 1.30199588255711 0.106044711795673 no 370 0.0964588965706922 562 5537 A vasodilator. SGTC_2034 5197015 53.07 µM 1.30035327539195 0.106335957165845 no 371 0.096739958180028 558 780676 SGTC_463 ikarugamyin 104 µM 1.29557729055644 0.107186052062628 no 372 0.0975605785964568 459 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2312 7706453 155.7 µM 1.28894998564042 0.108373772267711 no 373 0.0987077373783026 542 976098 SGTC_1761 st044296 37 µM 1.28853593349423 0.10844829019004 no 374 0.0987797343592233 542 1826700 SGTC_880 0833-0487 87.2 µM 1.28846100381247 0.10846177939656 no 375 0.0987927675261732 553 76075 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.28839943958355 0.10847286339245 no 376 0.0988034768661033 516 6708514 SGTC_1867 st057372 64 µM 1.28725186353314 0.108679621655178 no 377 0.0990032577655192 559 688837 SGTC_14 0354-0009 295 µM 1.28578005807872 0.108945210843012 no 378 0.0992599159026473 575 1713507 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.28471682987381 0.109137361788123 no 379 0.0994456274689862 481 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1617 st002906 78 µM 1.28383571461497 0.109296784982056 no 380 0.0995997221400566 575 5150859 SGTC_1852 st056254 31.4 µM 1.2824516068776 0.109547554027042 no 381 0.0998421353306631 543 442583 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.28073326268862 0.109859453680082 no 382 0.100143686098653 599 23665772 A membrane-active detergent. SGTC_1893 st059353 36.1 µM 1.27983550378981 0.11002266070536 no 383 0.100301497235665 565 3112488 SGTC_2359 9039622 200 µM 1.27700747147124 0.11053791645492 no 384 0.10079980474904 589 6463596 SGTC_733 4069-0007 56.1 µM 1.27336929842664 0.11120331736912 no 385 0.101443513277023 632 5717425 YNL287W SEC21 SGTC_1475 4092-1048 11.7 µM 1.27251057797676 0.111360789874009 no 386 0.101595884054352 610 2881759 SGTC_932 2857-0803 154 µM 1.2705336474039 0.111723926766361 no 387 0.101947302628118 616 674898 SGTC_3032 9089427 49.47 µM 1.26919706597043 0.111969919155159 no 388 0.102185393630716 518 17173707 SGTC_1833 st055984 71 µM 1.26637382141511 0.11249079826261 no 389 0.102689639385007 551 676288 SGTC_1112 tnp00069 1.16933 µM 1.26474087890437 0.11279285961034 no 390 0.102982115416011 631 145826 SGTC_3087 9117406 49.47 µM 1.26208738043105 0.113284937476545 no 391 0.1034586728444 553 42546093 SGTC_2511 berberine 10.47 µM 1.25995205728073 0.113682032912993 no 392 0.103843328866533 560 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1220 1838-0075 193 µM 1.25822371071239 0.114004170756734 no 393 0.104155431123085 583 5529645 SGTC_1297 1068-0111 14.1 µM 1.25743133075157 0.114152075703304 no 394 0.104298745043423 549 767057 SGTC_2470 5664817 21.68 µM 1.25699197310484 0.114234144691001 no 395 0.104378271095657 562 2859561 SGTC_815 1582-0027 36.9 µM 1.25619555949397 0.114383016376425 no 396 0.104522538160359 577 3128206 SGTC_2173 5763948 167 µM 1.25315034782968 0.114953524171918 no 397 0.105075497940264 599 2867177 SGTC_693 4161-2696 114 µM 1.25234103874352 0.115105484703177 no 398 0.105222810487292 506 805759 SGTC_579 4491-1009 110 µM 1.25188915840026 0.11519039447181 no 399 0.10530512790969 728 1271041 SGTC_2264 7948757 110.76 µM 1.24668568413563 0.116171353790408 no 400 0.106256385014624 556 2971411 SGTC_2844 9010103 25.97 µM 1.2418838846063 0.117081836008362 no 401 0.107139703401612 592 2480525 SGTC_1884 5633444 25 µM 1.23886228131111 0.117657355794948 no 402 0.107698252117574 614 5724239 SGTC_2016 5121758 140 µM 1.23869894514149 0.117688523111875 no 403 0.107728504750842 642 2795203 SGTC_527 4476-4215 268 µM 1.23826210201135 0.117771908917045 no 404 0.1078094455998 604 4418754 SGTC_484 loperamide 105 µM 1.23054464044911 0.119251936880899 no 405 0.109246610598114 491 3955 An opioid-receptor agonist. SGTC_1006 4099-6547 255 µM 1.228749068647 0.119598159731916 no 406 0.109582951301717 601 3146833 SGTC_2960 9079389 5.97 µM 1.22578452633452 0.120171334448987 no 407 0.110139885831451 610 16457355 SGTC_1122 capsaicin 818.572 nM 1.22478265389724 0.120365476774413 no 408 0.110328561125203 609 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2244 6635614 200 µM 1.22368183970833 0.120579046595254 no 409 0.110536136505378 463 836499 SGTC_9 0092-0002 10.449 µM 1.22300273760127 0.120710932725868 no 410 0.110664331153022 618 759368 SGTC_3007 9078383 71.4286 µM 1.21909321797144 0.121472162393342 no 411 0.111404406858779 612 6496995 SGTC_333 3486-0131 40.1 µM 1.21863286331137 0.121562020477442 no 412 0.111491784996225 620 6744690 SGTC_2952 9073731 13.78 µM 1.2181383995002 0.12165858846562 no 413 0.111585691877266 650 16457353 SGTC_2464 5717415 7.67 µM 1.21728353864508 0.121825668561689 no 414 0.111748177608893 618 5285744 SGTC_2677 mitomycin C 100 µM 1.2168624627947 0.121908025857032 no 415 0.111828274825976 559 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_174 3553-0389 74.3 µM 1.21581957055414 0.122112171203604 no 416 0.112026830967096 553 738071 SGTC_2783 7738165 71.43 µM 1.21526803203705 0.122220231430579 no 417 0.112131940164314 500 17201110 SGTC_125 0133-0007 11.75 µM 1.2142705380025 0.122415835989556 no 418 0.112322216125738 650 26541 SGTC_2696 st077691 74.316 µM 1.21283754140528 0.122697225192689 no 419 0.112595969568361 542 757133 SGTC_118 0083-0097 135.343 µM 1.21222112792785 0.12281840616904 no 420 0.112713872980546 828 5207356 SGTC_3167 9103034 49.47 µM 1.2086320735683 0.123525646859047 no 421 0.113402114261649 535 5127859 SGTC_2716 st080858 38.6235 µM 1.20862929116009 0.12352619625041 no 422 0.113402648979645 611 5296050 SGTC_2343 7990716 14.84 µM 1.20624349434152 0.123997906006753 no 423 0.113861808963248 627 6456862 SGTC_2198 6589944 200 µM 1.20620383308301 0.124005758301977 no 424 0.113869453173706 509 5290268 SGTC_130 0136-0219 337.655 µM 1.20054767775854 0.125129151761268 no 425 0.114963353783808 645 234244 SGTC_779 1360-0071 233 µM 1.20002030064975 0.125234257487459 no 426 0.115065728166637 677 7566 SGTC_2958 9077254 16.72 µM 1.19794217866426 0.125649025076703 no 427 0.115469763936075 578 16457351 SGTC_2287 7945887 168.79 µM 1.19716368750921 0.125804648830098 no 428 0.115621380176405 652 1245853 SGTC_2878 9043973 25.97 µM 1.19686609034631 0.125864175297572 no 429 0.11567937651703 586 6465167 SGTC_2378 9074213 121.43 µM 1.19551795602806 0.126134080070634 no 430 0.115942362504293 641 657714 SGTC_142 0335-0849 62.6745 µM 1.19530714047529 0.126176323091441 no 431 0.115983525491385 751 3889043 YPR107C YTH1 SGTC_1847 st056231 15 µM 1.19514499665558 0.126208820024787 no 432 0.116015192091685 671 5393180 SGTC_3294 9122953 26.2835 µM 1.1947018430661 0.126297666813895 no 433 0.116101771057205 638 16459826 SGTC_1642 st009582 77.7 µM 1.19413487840447 0.126411399725921 no 434 0.116212605861026 583 6739311 SGTC_2984 9022109 38.96 µM 1.19399698949865 0.126439070976466 no 435 0.116239572838759 578 6459207 SGTC_599 1935-0052 86.5 µM 1.19395793189725 0.126446909739245 no 436 0.11624721215341 657 9557311 SGTC_1418 3966-3099 2.4 µM 1.19385500143523 0.126467569247007 no 437 0.116267346130202 647 740335 SGTC_2722 naftopidil 47.16 µM 1.19385401852019 0.126467766542415 no 438 0.116267538407744 660 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1620 st003704 16.5 µM 1.18914440953357 0.127415564727869 no 439 0.117191422693557 643 2834414 SGTC_192 3455-0609 60.9 µM 1.1851986604067 0.128213432097239 no 440 0.117969454739612 614 3769639 SGTC_1393 3470-5649 58.2 µM 1.1812155255159 0.129022371625235 no 441 0.118758557590243 522 4108395 SGTC_3227 9130768 49.47 µM 1.18090028152007 0.129086545700421 no 442 0.118821169750441 651 17720899 SGTC_3117 9124945 49.47 µM 1.17670262893203 0.129943169572056 no 443 0.119657109096428 547 17592065 SGTC_1786 berberine 21.6 µM 1.17616248604338 0.130053682784921 no 444 0.11976497603351 636 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1290 0986-0249 10.2 µM 1.17402609957611 0.130491424759229 no 445 0.120192285866721 582 53329 SGTC_2733 amorolfine 100 µM 1.17301194316967 0.130699579951195 no 446 0.120395508167057 528 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_631 k072-0230 41.5 µM 1.17290469023524 0.130721606986513 no 447 0.120417014249053 691 5773147 SGTC_15 0266-0086 27.098 µM 1.17270035502213 0.130763579363652 no 448 0.120457994506937 758 1712902 YIL048W NEO1 SGTC_1648 st011736 69.8 µM 1.17137509661556 0.131036026050005 no 449 0.120724018903772 634 2855514 SGTC_750 4073-0104 132 µM 1.17121033833721 0.131069924453477 no 450 0.1207571203698 530 22330957 SGTC_2686 alizarin 95.37 µM 1.17087367307628 0.131139210916064 no 451 0.120824779406419 598 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2883 9059145 45.46 µM 1.1651835722237 0.132314074572791 no 452 0.121972346922869 610 16476510 SGTC_2214 7179297 48.276 µM 1.16511054876928 0.132329199091988 no 453 0.121987123721839 659 769744 SGTC_409 arachidonic acid 100 µM 1.16455994501526 0.132443277762943 no 454 0.122098582665616 654 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.16451873673272 0.132451818363076 no 455 0.122106927350516 688 688751 SGTC_2867 9039098 71.43 µM 1.16008089307399 0.133373803043278 no 456 0.123007936308584 653 6463460 SGTC_1550 gossypolone 36.6 µM 1.15880880273155 0.133638898520775 no 457 0.123267064290326 665 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1516 st013856 110 µM 1.15856665434381 0.133689401711256 no 458 0.123316433826249 620 5281404 A mutagen and neurotoxin. SGTC_969 1313-0238 134 µM 1.14685430343332 0.13614784105461 no 459 0.125720920741876 698 5212874 SGTC_1996 st072960 66.8 µM 1.14624386799027 0.13627681521939 no 460 0.125847130669432 708 1719405 SGTC_1321 1326-2144 215 µM 1.14467496224191 0.136608680586198 no 461 0.1261719134342 641 3513030 SGTC_741 4582-0002 126 µM 1.1440872648759 0.136733136400265 no 462 0.126293724296953 660 2912688 SGTC_1486 3970-0793 4.53 µM 1.14400702346031 0.136750135020312 no 463 0.126310362131945 670 2844330 SGTC_2383 9036125 200 µM 1.14059936006197 0.137473359921358 no 464 0.127018341844231 623 79580 SGTC_2512 diallyl trisulfide 49.23 µM 1.13988048618018 0.137626262945949 no 465 0.127168047918468 627 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.13551951560308 0.138556320125102 no 466 0.128078854877773 706 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1089 terbinafine 2.25 µM 1.13550439252123 0.138559552833786 no 467 0.128082021260829 663 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_151 3013-0144 2.285 µM 1.13533421696553 0.138595933088704 no 468 0.128117655378951 697 906558 YHR107C CDC12 SGTC_638 3970-0837 4.09 µM 1.13360811078724 0.13896530910419 no 469 0.128479484651692 683 4118451 YLR208W SEC13 SGTC_2561 acetosyringone 100 µM 1.13266855990893 0.139166648612828 no 470 0.128676732727735 778 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_755 1995-0008 37.3 µM 1.13212371203816 0.139283496792294 no 471 0.128791213580632 706 689533 SGTC_615 k087-0205 167 µM 1.13079163858246 0.139569454573706 no 472 0.129071400023371 645 9642773 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.12916709392792 0.139918737520252 no 473 0.12941367610104 690 688664 SGTC_847 0342-0274 5.54 µM 1.12669138195786 0.140452166115981 no 474 0.129936493703996 707 18097 SGTC_1942 st076330 65.2 µM 1.12423344411924 0.140983129242786 no 475 0.130457002461315 671 24208414 SGTC_2206 7254556 146.969 µM 1.12221435687235 0.14142030924632 no 476 0.130885654879375 636 4398905 SGTC_1773 st048542 73.5835 µM 1.1216256857508 0.141547943223393 no 477 0.131010812869928 687 3237138 SGTC_2302 7771753 200 µM 1.12139935950334 0.141597035394086 no 478 0.131058954333259 689 2203047 SGTC_1512 0259-0544 12.2 µM 1.11970904951956 0.141964043384598 no 479 0.131418883714165 745 18476 SGTC_40 0327-0103 19.753 µM 1.11893869197353 0.142131520461482 no 480 0.131583147446768 675 409036 SGTC_1154 4088-0362 150 µM 1.11875125941404 0.14217228884473 no 481 0.131623135211488 749 6618304 SGTC_2142 5622915 118.518 µM 1.11744182776725 0.142457323571097 no 482 0.131902729619139 654 5322196 SGTC_1944 st076371 56.9 µM 1.11643678306435 0.142676361915242 no 483 0.132117607972831 672 24208455 SGTC_3232 9132874 49.47 µM 1.11583732143439 0.142807116284068 no 484 0.132245887601456 657 3784940 SGTC_2305 7443522 69.23 µM 1.11541026135219 0.142900315876177 no 485 0.132337327138614 736 5415886 SGTC_2334 9017922 200 µM 1.11461235158341 0.143074558095916 no 486 0.132508287527516 712 3163164 SGTC_2419 paclitaxel 166.5 µM 1.11301608108775 0.143423571674929 no 487 0.132850761507932 730 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3254 9136651 49.47 µM 1.11232122130597 0.143575677415191 no 488 0.133000031363682 729 16454030 SGTC_1495 4469-0029 237 µM 1.11042698132093 0.143990881917028 no 489 0.133407538432443 802 793680 SGTC_3310 9130229 44.1445 µM 1.10617886071133 0.14492498307253 no 490 0.13432455534068 682 7761258 SGTC_1033 k072-0102 21.3 µM 1.10499854268434 0.145185240804277 no 491 0.13458011029875 721 5965931 SGTC_2140 5586273 200 µM 1.10411901580728 0.145379379070511 no 492 0.134770756726453 652 854421 SGTC_1073 triclabendazole 3.09 µM 1.1001440601742 0.146258949625282 no 493 0.135634679610423 749 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3337 9144342 33.5465 µM 1.09821054800358 0.146688082791123 no 494 0.136056280679063 717 17682949 SGTC_482 fipronil 114 µM 1.09383071214083 0.147663286757693 no 495 0.137014615814769 661 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_309 k408-0051 1.48 µM 1.09288395178045 0.14787465965833 no 496 0.137222377640756 766 3640463 SGTC_2917 7979103 53.79 µM 1.0918548352529 0.148104648983529 no 497 0.137448456077047 764 2980565 SGTC_3109 9122853 49.47 µM 1.0890507521888 0.148732526043482 no 498 0.138065752757724 773 1234709 SGTC_2409 alverine citrate 63.97 µM 1.08899339551152 0.148745387621126 no 499 0.138078399076859 702 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2385 9074692 200 µM 1.08886192128739 0.148774872014208 no 500 0.138107390225452 715 17046906 SGTC_347 4534-1311 26.2 µM 1.08698849577705 0.149195430559365 no 501 0.138520946964569 706 2862016 SGTC_2370 9071495 200 µM 1.08564191234512 0.149498210169096 no 502 0.138818724592074 679 21791103 SGTC_614 0462-0418 107 µM 1.0802154373705 0.150722508228771 no 503 0.140023127784804 658 5188303 SGTC_1199 1638-0010 4.46 µM 1.07851834773082 0.151106764907202 no 504 0.140401249116907 740 3111136 SGTC_2372 9071633 200 µM 1.07736840009262 0.151367507315845 no 505 0.140657857778118 792 21321366 SGTC_295 k015-0027 31 µM 1.07667197504115 0.151525562108575 no 506 0.140813418384583 724 3887424 SGTC_647 0140-0236 81 µM 1.07623252023571 0.151625353530341 no 507 0.140911639540326 819 990837 SGTC_475 α-linolenic acid 10 µM 1.07594101343741 0.151691573004625 no 508 0.140976818937829 762 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_656 4090-1979 187 µM 1.07432777233649 0.152058388701649 no 509 0.141337900924658 785 22330961 SGTC_2855 9016525 58.44 µM 1.07313659865008 0.152329613284193 no 510 0.141604916092155 724 43811474 SGTC_2082 5219693 150 µM 1.07197231889979 0.152595024397447 no 511 0.141866232738531 722 2834649 SGTC_2352 9027995 87.8 µM 1.07150556735407 0.152701511943653 no 512 0.141971084376695 669 2997347 SGTC_306 1672-3436 11.6 µM 1.06940538520572 0.153181270078475 no 513 0.142443520896136 747 6797378 SGTC_1001 4048-4355 44.4 µM 1.06884100266181 0.153310365719997 no 514 0.142570659970077 729 21824233 SGTC_2272 7805186 180 µM 1.06783126777552 0.153541510087253 no 515 0.142798315467588 746 2956062 YPR165W RHO1 SGTC_221 trifluoperazine 10.304 µM 1.06252145035756 0.154760807809652 no 516 0.143999512680725 866 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1721 st082152 9.2685 µM 1.06146394115821 0.155004406332632 no 517 0.144239555864573 688 5296051 SGTC_2611 pyromycin 23.93 µM 1.06086050822718 0.155143521241678 no 518 0.144376649441534 706 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2440 5628896 157.78 µM 1.05885782463418 0.155605808755827 no 519 0.144832267158401 730 5522048 SGTC_1714 st033236 13.627 µM 1.05790857052168 0.155825245977751 no 520 0.145048563735126 746 2916566 SGTC_1559 coumarin 343 70.1 µM 1.05712776897109 0.156005895206521 no 521 0.145226639686273 702 108770 A hepatotoxic, DNA x-linker. SGTC_860 0443-0016 25.1 µM 1.05639439747563 0.156175696495174 no 522 0.145394032271694 768 5337942 SGTC_1376 2910-0861 41.3 µM 1.05509694928852 0.156476399541341 no 523 0.145690493573362 766 1112859 SGTC_2904 7225135 42.03 µM 1.05385592621771 0.15676438172362 no 524 0.145974441984467 789 4446116 SGTC_10 0279-0212 42.575 µM 1.05201404651704 0.157192436632338 no 525 0.146396552576022 839 39851 YBR002C RER2 SGTC_2979 9012552 45.46 µM 1.04689870871275 0.158385274449393 no 526 0.147573148750565 701 17100905 SGTC_991 3996-0057 64.7 µM 1.04550852863111 0.158710471938354 no 527 0.147894000456601 738 715343 SGTC_1350 1495-0454 146 µM 1.04424074759453 0.159007418627242 no 528 0.148187009479745 795 1069057 SGTC_448 monastrol 171 µM 1.04251381695454 0.159412495170423 no 529 0.148586761464394 752 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_3276 9139060 49.47 µM 1.03778781661605 0.1605244982027 no 530 0.149684425077201 719 4870619 SGTC_2730 imipramine 71.33 µM 1.0374360767536 0.160607462867817 no 531 0.149766336140642 890 3696 A tricyclic antidepressant. SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.03715290465777 0.160674274842078 no 532 0.14983230127678 734 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2553 4-methylesculetin 85.09 µM 1.03653367408267 0.160820440105672 no 533 0.149976618983232 769 5319502 SGTC_1575 cyproterone acetate 48 µM 1.03624129035649 0.160889485504968 no 534 0.15004479405836 731 9880 An androgen receptor antagonist and liver toxin. SGTC_1487 3970-0795 2.82 µM 1.03475679796001 0.161240341714893 no 535 0.150391251681168 802 3765103 SGTC_1417 3966-0327 90.4 µM 1.03380043685701 0.161466639519355 no 536 0.15061473368807 815 651118 SGTC_1809 st050081 57.6 µM 1.03291354904806 0.161676683274981 no 537 0.150822178766459 774 5036894 SGTC_2690 usnic acid 100 µM 1.03000301024177 0.162367243767039 no 538 0.151504296244263 832 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_481 bay k-8644 50 µM 1.02961001859736 0.162460632680185 no 539 0.151596555175077 710 2303 A calcium channel antagonist. SGTC_3163 9099914 49.47 µM 1.02909595387902 0.162582845657405 no 540 0.151717293651061 727 16268368 SGTC_3218 9131285 49.47 µM 1.02840793520231 0.162746507764834 no 541 0.151878988703701 847 17156417 SGTC_93 0109-0045 59.227 µM 1.0252310775812 0.163503590355043 no 542 0.152627083840449 913 88733 SGTC_2938 9059746 27.26 µM 1.0250594924622 0.163544546109717 no 543 0.152667558638227 738 6471769 SGTC_1910 st062352 60.4 µM 1.02287365958452 0.164066866790778 no 544 0.153183792517222 756 2245730 SGTC_2813 7971799 71.43 µM 1.0209209336521 0.164534399031141 no 545 0.153645950146065 756 2234054 SGTC_3213 9129884 49.47 µM 1.0206938765494 0.164588818257487 no 546 0.153699748298612 692 17190742 SGTC_1303 1160-0052 261 µM 1.02022137216653 0.164702101707301 no 547 0.153811741885355 789 3562476 SGTC_2467 5474540 200 µM 1.01743109359881 0.165372103756955 no 548 0.1544741982875 782 5413519 SGTC_850 0388-0143 75.9 µM 1.01594866916631 0.16572878001386 no 549 0.15482691544033 743 67273 SGTC_2610 ononetin 44.17 µM 1.01534637552454 0.165873835855928 no 550 0.154970372624979 779 259632 SGTC_3307 9126885 69.2785 µM 1.0140427624383 0.166188077760545 no 551 0.155281173961947 792 24824909 SGTC_575 k072-0246 11.9 µM 1.01320866137685 0.166389343248075 no 552 0.15548025211917 808 6796779 SGTC_387 norethindrone acetate 66.7 µM 1.01172096545811 0.166748709266401 no 553 0.155835744141657 742 541197 SGTC_1024 4507-0395 26 µM 1.01049599588707 0.167044987086223 no 554 0.156128858422813 756 4201836 SGTC_3097 9117246 49.47 µM 1.0103822621506 0.16707251255939 no 555 0.156156091380559 790 16423892 SGTC_2051 5263410 176 µM 1.00818761306205 0.167604227116995 no 556 0.156682201672937 814 227584 SGTC_1269 0831-0796 3.05 µM 1.00690820950276 0.167914700446497 no 557 0.156989443254903 802 927758 SGTC_1016 4226-1401 38 µM 1.00590651766641 0.168158039599704 no 558 0.157230270358217 793 2901613 SGTC_3341 9147222 25.867 µM 1.00341240031519 0.168764916169928 no 559 0.157830961763246 751 1939759 SGTC_2485 5633444 17.78 µM 1.00057601853172 0.169456781796443 no 560 0.15851591445262 767 5724239 SGTC_578 3460-0051 92 µM 1.00044827372654 0.169487984775837 no 561 0.158546809124991 916 2876744 SGTC_2557 derrustone 83.84 µM 1.00013533632801 0.169564438523184 no 562 0.158622508718073 813 629853 An antioxidant. SGTC_2778 tioconazole 65.09 nM 0.999686366294397 0.16967416504577 no 563 0.158731156007294 781 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2478 5763493 32.33 µM 0.999130347103433 0.16981011707746 no 564 0.158865775973673 822 1365576 YLR208W SEC13 SGTC_2031 5180455 200 µM 0.998981916510295 0.169846421592265 no 565 0.158901725731661 770 29949 SGTC_1254 0550-0035 264 µM 0.998592834435641 0.169941610471391 no 566 0.158995986367426 848 15121435 SGTC_2283 7944793 200 µM 0.995689452687831 0.170653001931967 no 567 0.159700528187702 799 2970533 SGTC_2537 larixol 68.93 µM 0.995629259362646 0.170667770743868 no 568 0.159715156431388 854 6708759 SGTC_811 0416-0114 265 µM 0.995128934106847 0.170790560362748 no 569 0.159836779917362 784 6612453 SGTC_1392 3455-1037 33.9 µM 0.994802146016213 0.170870791077296 no 570 0.159916251155657 795 981132 SGTC_1274 0865-0114 173 µM 0.992746630778525 0.171375999524711 no 571 0.160416722086349 798 870624 SGTC_613 3914-0030 117 µM 0.992429535715246 0.171454020675863 no 572 0.160494018497603 591 1145395 SGTC_681 1642-0006 26.6 µM 0.992344200264493 0.171475021315612 no 573 0.160514824376539 796 4446530 SGTC_1860 st056228 74.6 µM 0.988908059003882 0.172322004543678 no 574 0.161354063593583 788 688679 SGTC_989 1501-0895 10.3 µM 0.983525773113904 0.173654052604954 no 575 0.162674368502514 838 2830112 SGTC_2029 5175081 200 µM 0.982752309936057 0.173846011968766 no 576 0.162864679267796 845 1380876 SGTC_1606 st000094 49.2 µM 0.982555169500811 0.173894960180079 no 577 0.162913208853413 877 1242210 SGTC_913 3487-1245 167 µM 0.981881938311115 0.174062183539935 no 578 0.163079007422791 779 4016153 SGTC_1628 st004252 77.7 µM 0.980999323758347 0.17428157027236 no 579 0.163296537514729 827 692968 SGTC_1366 1683-0113 21.9 µM 0.980530905668225 0.174398073763641 no 580 0.163412060857725 798 708623 SGTC_854 0422-0053 192 µM 0.980249050279833 0.174468199795429 no 581 0.163481598856248 810 3596728 SGTC_2903 5923464 63.88 µM 0.978149837125548 0.17499105041509 no 582 0.164000111052214 808 2876576 SGTC_2404 5161160 200 µM 0.977784177677714 0.175082226710442 no 583 0.164090539071083 855 2831543 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.976550299005163 0.17539011373105 no 584 0.164395917402034 899 688801 SGTC_2822 7994718 71.43 µM 0.976535596560856 0.175393784467674 no 585 0.164399558397638 733 1018011 SGTC_1816 st051957 91.6 µM 0.975759048705031 0.17558773319303 no 586 0.164591941351848 832 674121 SGTC_814 3342-0569 96 µM 0.973445866285782 0.176166273094946 no 587 0.165165876269842 839 4346283 SGTC_573 3702-0553 84.7 µM 0.970967904468295 0.176787362150916 no 588 0.165782130748083 814 1222756 SGTC_3008 9078912 71.4286 µM 0.969403715029491 0.177180130377296 no 589 0.166171899744367 802 16648731 SGTC_2580 diallyl disulphide 81.36 µM 0.969322872920435 0.177200444812083 no 590 0.166192060276743 789 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_825 1988-2224 89.6 µM 0.968458465025733 0.17741774977322 no 591 0.166407726437153 837 1180859 SGTC_11 0438-0307 1.3 µM 0.966925954747865 0.177803423450873 no 592 0.166790525315109 822 4011476 SGTC_369 0957-0393 4.5 µM 0.962541191034057 0.178909817693829 no 593 0.167888911191699 781 6997992 SGTC_577 r071-0003 38.6 µM 0.961008522931561 0.179297570991974 no 594 0.16827394123861 982 4568517 YMR134W ERG29 SGTC_1316 1272-0050 65.9 µM 0.957602608487676 0.180161131589328 no 595 0.169131591663037 825 7340392 SGTC_3041 9091929 49.47 µM 0.956400146346114 0.180466635223993 no 596 0.169435055412556 871 25236887 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.953389662517547 0.181232918248968 no 597 0.170196338573657 864 2724 A muscle relaxant with antifungal properties. SGTC_3056 9094900 49.47 µM 0.952301654574948 0.181510358374977 no 598 0.170472009474311 828 25236784 SGTC_1268 0828-0275 2.46 µM 0.950735269097126 0.181910250526303 no 599 0.170869389778096 896 745337 SGTC_211 3455-0679 143.504 µM 0.946705576916303 0.182941544910195 no 600 0.171894413924499 878 748649 SGTC_162 k030-0015 37.8 µM 0.946694722990073 0.182944327606615 no 601 0.171897180105749 928 1809920 YMR134W ERG29 SGTC_2838 9002687 71.43 µM 0.946692057929421 0.182945010870755 no 602 0.171897859315081 795 6457060 SGTC_3300 9124615 50.48 µM 0.945051647764785 0.18336587882338 no 603 0.172316254441237 855 24824903 SGTC_1127 asiatic acid 681.4 nM 0.944897661604607 0.18340541688704 no 604 0.172355562739452 805 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2712 st079126 47.7 µM 0.944711166349643 0.183453309223613 no 605 0.172403177345909 818 3152970 SGTC_1304 1165-0502 251 µM 0.942722810890147 0.183964407224987 no 606 0.172911351262899 892 767425 SGTC_2436 5633522 8.09 µM 0.938135096386356 0.185147037814203 no 607 0.174087493777019 900 5724242 SGTC_381 3461-2219 42.7 µM 0.937608057732603 0.18528320069004 no 608 0.174222934464064 884 2883159 SGTC_1663 st014140 55.4 µM 0.936502275603657 0.185569086646627 no 609 0.174507320739974 1012 4207120 SGTC_1691 st019933 84.6 µM 0.933197647635898 0.186425086540347 no 610 0.175358964539322 865 6176082 SGTC_3006 9075424 71.4286 µM 0.930754526474462 0.187059499653709 no 611 0.175990278554774 831 7465181 SGTC_2062 5245942 200 µM 0.926497408387453 0.188168145576528 no 612 0.177093771656146 961 1376160 SGTC_2621 lithochol-11-enic acid 100 µM 0.925178359605578 0.188512475649242 no 613 0.177436569089274 910 6708711 SGTC_1161 k007-0610 110 µM 0.922976853947376 0.189088030742168 no 614 0.17800963372976 976 5843850 SGTC_2908 7930301 100 µM 0.921736002471252 0.189412911655555 no 615 0.17833314820677 933 2223178 SGTC_74 000s-0487 160.283 µM 0.921065887483142 0.189588504571919 no 616 0.178508014376153 938 677548 SGTC_350 k064-0020 19.8 µM 0.916460214562095 0.19079805512944 no 617 0.179712782770303 939 2790705 SGTC_2945 9067681 61.76 µM 0.913992517610191 0.19144807012964 no 618 0.180360388689219 879 16456930 SGTC_1166 k206-0078 225 µM 0.910441335438599 0.192385863488708 no 619 0.181294903383689 916 5404595 SGTC_1171 0368-0077 21.4 µM 0.910355483390305 0.192408569949386 no 620 0.181317533334383 849 3239779 SGTC_2961 9083290 32.55 µM 0.908977560264415 0.192773232222856 no 621 0.18168098543878 861 17741490 SGTC_2224 6650123 117.647 µM 0.908462045591322 0.192909769747531 no 622 0.181817078835633 877 2908370 SGTC_2797 7859098 81.82 µM 0.907303366866618 0.193216869096239 no 623 0.182123197113827 887 972681 SGTC_550 4123-0385 25.7 µM 0.907146984768936 0.193258339873743 no 624 0.182164537300236 890 5731123 SGTC_1041 0206-0046 107 µM 0.90694674136399 0.193311450108651 no 625 0.182217480948727 893 50494 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.905912656780798 0.193585860429215 no 626 0.182491042299183 866 688803 SGTC_2236 dapsone 200 µM 0.905202114092587 0.193774551537963 no 627 0.182679161047142 969 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_3151 9099821 49.47 µM 0.905143615065416 0.193790091483513 no 628 0.18269465426908 882 17174189 SGTC_244 nsc-207895 1.295 µM 0.904291589526152 0.194016513495824 no 629 0.182920402643934 795 42640 SGTC_914 3820-6779 408 µM 0.8980261362022 0.195686475972078 no 630 0.184585807840751 915 2893481 SGTC_2638 epoxomicin 18 µM 0.896073395107585 0.196208728112622 no 631 0.185106782628622 948 9915668 A protesome inhibitor. SGTC_3321 9137793 26.8275 µM 0.89402169050871 0.196758357116275 no 632 0.185655142964583 914 4904192 SGTC_2233 sulbentine 40.3845 µM 0.893736021579568 0.196834958551232 no 633 0.185731573730576 949 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_276 colchicine 750 µM 0.89092828839869 0.197588805986562 no 634 0.186483821538916 940 2833 A microtubule depolymerizer. SGTC_48 0382-0018 55 µM 0.890192966818302 0.197786520267187 no 635 0.186681140255928 907 762596 SGTC_1515 3460-0031 42.1 µM 0.890049682902949 0.197825060555571 no 636 0.186719604595381 864 2876596 SGTC_3171 9103192 49.47 µM 0.88995995110919 0.197849198786529 no 637 0.186743695450945 958 13018434 SGTC_3160 9100216 49.47 µM 0.887356980718796 0.198550183027084 no 638 0.1874433683947 935 17191039 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.886317007034149 0.19883066798804 no 639 0.18772336352715 932 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1865 st057639 52.2 µM 0.88589835975055 0.198943646190777 no 640 0.187836150045314 957 688818 SGTC_2323 6148992 148.28 µM 0.884756354223015 0.199252030038341 no 641 0.188144027066372 825 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1422 4031-0024 15.5 µM 0.884325537559939 0.199368441264217 no 642 0.188260253202938 915 782427 SGTC_1629 st005085 44.9 µM 0.884158571193202 0.199413568353439 no 643 0.188305309459578 909 24207091 SGTC_1386 3228-0095 33.8 µM 0.884038203754834 0.199446104660532 no 644 0.188337795014875 892 870181 SGTC_1339 1486-1321 22.7 µM 0.880184870225854 0.200489380255779 no 645 0.189379584166354 928 3469382 SGTC_2279 7948423 32.93 µM 0.880149874049782 0.200498870332664 no 646 0.189389061973405 925 1247112 SGTC_675 1309-0189 238 µM 0.879545395341932 0.200662832223611 no 647 0.189552815429449 890 4246530 SGTC_1436 4092-1007 8.32 µM 0.878683585297434 0.200896733121895 no 648 0.189786430601242 936 2881121 SGTC_2350 9023895 38.85 µM 0.877400047139784 0.201245396903597 no 649 0.190134693783499 916 2997209 SGTC_997 3996-0078 137 µM 0.876284941837742 0.201548601441111 no 650 0.190437574543128 964 735687 SGTC_1425 4048-4433 7.33 µM 0.876094513420061 0.201600407540107 no 651 0.190489327605714 994 23734946 SGTC_3040 9091894 49.47 µM 0.875389645487944 0.201792236440466 no 652 0.19068096592121 868 25236966 SGTC_731 3966-0296 387 µM 0.875162332295209 0.201854122733731 no 653 0.190742792676741 927 660956 SGTC_22 0964-0034 14.468 µM 0.873424138503806 0.202327723666058 no 654 0.191215969384726 978 138402 SGTC_2274 7947094 46.08 µM 0.873078818940678 0.202421891016266 no 655 0.191310058997104 1022 2971028 SGTC_1835 st008666 49.2 µM 0.872370554645905 0.202615114013967 no 656 0.191503129340119 839 690455 SGTC_2486 5283202 22.39 µM 0.871578032861395 0.202831454106291 no 657 0.19171930944297 873 1377751 SGTC_2178 5812956 200 µM 0.871402543690517 0.202879377240442 no 658 0.191767198697207 965 5403383 SGTC_3046 9092212 49.47 µM 0.869784754419733 0.203321486707579 no 659 0.192209022266587 926 25236637 SGTC_3020 9089140 49.47 µM 0.867624590882071 0.203912711712479 no 660 0.192799939950297 974 17217859 SGTC_1958 st076513 41.9 µM 0.867471975006801 0.203954520559013 no 661 0.192841730306509 968 732122 YGL099W LSG1 SGTC_2521 angolensin 13.4 µM 0.86564175938356 0.204456302674155 no 662 0.193343323839158 927 821428 A flavenoid. SGTC_420 mitomycin C 81.9 mM 0.86529794546847 0.20455064652662 no 663 0.193437639099046 936 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3280 9140961 49.47 µM 0.864885901990186 0.204663746952077 no 664 0.193550708106795 909 4901226 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.861721719432576 0.205533511839428 no 665 0.194420335339199 969 688667 SGTC_36 0335-0881 14.2 µM 0.858317242804934 0.206471774902594 no 666 0.195358655381097 972 23828853 SGTC_952 1185-0122 232 µM 0.858067545455137 0.206540690444344 no 667 0.195427583482806 955 678600 SGTC_94 0334-0113 514.748 µM 0.857142046245247 0.206796243608639 no 668 0.195683193200959 961 6795178 SGTC_982 1491-0518 27.5 µM 0.856981990899051 0.206840457815904 no 669 0.195727418786669 900 3091256 SGTC_2195 6536160 144.242 µM 0.856052302226301 0.207097388654401 no 670 0.195984425039747 907 3834386 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.855759583580394 0.207178324098624 no 671 0.196065387522307 912 4620898 SGTC_2818 7996756 12.99 µM 0.855165236024954 0.207342716182903 no 672 0.196229839361089 919 2241621 SGTC_2044 5102272 200 µM 0.853547316627068 0.207790611121379 no 673 0.196677929938802 896 592666 SGTC_3229 9132204 49.47 µM 0.852850744762478 0.207983621673307 no 674 0.196871039583686 969 17682924 SGTC_2600 tangeritin 87.95 µM 0.851233602435367 0.208432117615897 no 675 0.197319800102187 917 68077 A bioactive flavone. SGTC_1506 4226-2149 212 µM 0.849878442086252 0.208808394734921 no 676 0.197696336131209 1021 991114 SGTC_802 4112-3352 742 µM 0.849761988423367 0.208840748207371 no 677 0.197728713436323 1013 704594 SGTC_348 k064-0012 10.7 µM 0.84921438487213 0.208992924505727 no 678 0.197881005165481 909 5066323 SGTC_3068 9116768 49.47 µM 0.847367720138082 0.209506584689737 no 679 0.198395095509509 939 41904888 SGTC_1231 0242-0792 125 µM 0.846478667307919 0.209754144352578 no 680 0.198642884780127 963 3707635 SGTC_1490 4089-0339 670 nM 0.84535562775931 0.210067104094697 no 681 0.198956155492549 953 742542 SGTC_2300 7976697 71.57 µM 0.844825186834637 0.210215018497306 no 682 0.199104224903868 870 2236109 SGTC_144 4161-2749 112.381 µM 0.84471545094422 0.21024562618142 no 683 0.199134865307047 877 797501 YMR168C CEP3 SGTC_1302 1159-0335 255 µM 0.842635478885655 0.210826269591905 no 684 0.19971617114002 949 649284 SGTC_3340 9146634 11.102 µM 0.841691271835669 0.211090163767143 no 685 0.199980392531367 969 4907387 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.840979541814009 0.211289211399588 no 686 0.200179697764349 977 364106 SGTC_2924 9010168 62.78 µM 0.839645059955233 0.211662718592364 no 687 0.20055371333833 989 2993929 SGTC_178 4092-0806 87.505 µM 0.837600276825358 0.212235780649873 no 688 0.201127618660654 986 2169044 SGTC_1015 4130-4525 82 µM 0.837505746545311 0.212262295210345 no 689 0.201154174088088 980 1363237 SGTC_3099 9120367 49.47 µM 0.837344357387274 0.212307567323434 no 690 0.201199516357033 990 24824940 SGTC_2484 5809818 12.04 µM 0.836496453260551 0.212545510012914 no 691 0.201437835603534 948 2870548 SGTC_3258 9138477 49.47 µM 0.836363314158979 0.21258288625376 no 692 0.201475272189084 1029 4970355 SGTC_1335 1486-0900 202 µM 0.835863158578682 0.212723329601437 no 693 0.201615945182643 1032 X1335 SGTC_1989 st071868 50.2 µM 0.834572464138794 0.213086005903333 no 694 0.201979235660085 1032 16414057 SGTC_3027 9089541 49.47 µM 0.833106994636126 0.21349822975954 no 695 0.202392194547635 992 9943819 SGTC_1241 0364-0022 50.8 µM 0.832314569528453 0.213721325526517 no 696 0.202615704476027 991 4563895 SGTC_1469 k284-2957 126 µM 0.832259998375866 0.213736694237048 no 697 0.202631102139994 1010 23884841 SGTC_1134 3477-0009 42.5 µM 0.828981528741474 0.214661180209995 no 698 0.203557429709743 1016 3973534 SGTC_957 1187-1561 14.1 µM 0.828773399860385 0.214719948203143 no 699 0.20361632140299 1010 1538454 SGTC_2759 disulfiram 3.38 µM 0.828591802717678 0.214771232239153 no 700 0.203667714032713 982 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.827923142380871 0.214960126947212 no 701 0.203857013918325 1077 5282309 SGTC_2143 5623677 140.463 µM 0.826877674630568 0.215255661994613 no 702 0.204153199258209 991 5375313 SGTC_1793 st048256 72.231 µM 0.825346164030077 0.215689018116788 no 703 0.204587544989141 975 672022 SGTC_265 mycophenolic acid 32.932 µM 0.825070156498762 0.215767170942703 no 704 0.204665880840081 1043 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1149 3909-7961 23.3 µM 0.824230742962185 0.216004955665262 no 705 0.204904230976153 990 735261 SGTC_2087 5276107 200 µM 0.824209195421935 0.216011061538734 no 706 0.20491035153775 1011 144405 SGTC_2953 9074162 66.49 µM 0.824197325574916 0.216014425110792 no 707 0.204913723204746 941 16451992 SGTC_1909 st060837 51.5 µM 0.824140075353118 0.216030648597368 no 708 0.204929985771685 942 678937 SGTC_1135 dihydrocapsaicin 536.708 nM 0.82375139179204 0.216140811854162 no 709 0.205040415980143 931 107982 A Capsaicinoid. SGTC_483 fpl-64176 144 µM 0.821599802930913 0.216751217559737 no 710 0.205652350748129 980 3423 SGTC_2355 9061122 103.12 µM 0.821286662025851 0.216840138650858 no 711 0.205741501630203 1026 5302957 SGTC_362 0310-0100 9.03 µM 0.821178490199061 0.216870860575867 no 712 0.205772303362944 981 790235 SGTC_2344 7990960 76.95 µM 0.821163569619933 0.216875098373153 no 713 0.205776552185701 938 140813 SGTC_2427 5545055 42.75 µM 0.820317220878631 0.217115559791203 no 714 0.206017645862237 1050 5372858 SGTC_2996 9066192 71.4286 µM 0.819457058656597 0.217360103601196 no 715 0.206262846056774 1016 6472854 SGTC_2228 7354201 200 µM 0.817923421747403 0.217796510375619 no 716 0.206700457691461 1052 753451 SGTC_3186 9110464 49.47 µM 0.816878185505024 0.218094228817527 no 717 0.206999022679024 993 17018021 SGTC_1488 4013-0813 75.9 µM 0.814413610769826 0.218797150510841 no 718 0.207704021983944 969 2910057 SGTC_959 1222-0044 107 µM 0.81275485731088 0.219270976867775 no 719 0.208179311176882 1035 6083612 SGTC_364 0083-0097 67.7 µM 0.811214504866793 0.219711509385451 no 720 0.208621248646658 1015 5207356 SGTC_3273 9137859 49.47 µM 0.810887384462746 0.219805129436811 no 721 0.208715172835864 1080 2377234 SGTC_2174 5790901 200 µM 0.810063167728964 0.220041117216452 no 722 0.2089519358954 993 786020 SGTC_3208 9114115 49.47 µM 0.808897222095693 0.220375196115667 no 723 0.209287133456765 935 650895 SGTC_1815 st051655 58.2 µM 0.808529001154938 0.220480762998123 no 724 0.209393058971601 1010 5984156 SGTC_1567 st069303 68.4 µM 0.807684552371237 0.220722971145033 no 725 0.209636099269041 1032 5581319 SGTC_1931 st074438 57.1 µM 0.806991537480739 0.220921858221578 no 726 0.209835679354451 1035 2787313 SGTC_1806 st050005 60.3 µM 0.806554722389122 0.221047271679499 no 727 0.209961534297317 998 5194765 SGTC_3320 9137005 35.139 µM 0.805520878555626 0.221344259619205 no 728 0.21025958153675 959 4908713 SGTC_2066 5222451 176 µM 0.80551239466839 0.221346697693128 no 729 0.210262028387247 1092 2281147 SGTC_3115 9123671 49.47 µM 0.805046283409946 0.221480670938476 no 730 0.210396485920908 1117 3286988 SGTC_876 0720-0963 56.8 µM 0.804435264304109 0.221656364894465 no 731 0.210572820962925 1059 765861 SGTC_2618 avocadyne 43.43 µM 0.803151947659604 0.222025632133932 no 732 0.210943457721744 1014 3015189 SGTC_1552 6-methylflavone 10.6 µM 0.798925749618658 0.223244176860972 no 733 0.212166733546073 1009 689013 SGTC_2408 sulbentine 18.36 µM 0.79891205682204 0.22324813109814 no 734 0.21217070366345 990 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1087 pterostilbene 9.05 µM 0.798479209227378 0.22337315036496 no 735 0.212296226762465 1054 5281727 Similar to reservatol, lowers cholesterol. SGTC_2138 5575593 77.673 µM 0.798357525467036 0.223408303428721 no 736 0.212331522107019 1065 762213 SGTC_3290 9121031 71.43 µM 0.798340935338458 0.22341309637327 no 737 0.212336334471668 992 17014854 SGTC_1101 ebselen 5.29 µM 0.796204295172056 0.224030867759374 no 738 0.21295665073152 1125 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3161 9100388 49.47 µM 0.795835978917059 0.224137457808447 no 739 0.213063688247872 1077 25236368 SGTC_1042 0350-0096 82 µM 0.795579414640169 0.2242117240564 no 740 0.213138267721866 1015 3122515 SGTC_140 0062-0056 502.533 µM 0.795180990873529 0.224327081282763 no 741 0.213254113847811 1102 3758964 SGTC_3016 9080866 49.47 µM 0.794800695942885 0.224437221015491 no 742 0.213364723054526 1083 17066299 SGTC_2680 butyl paraben 22.24 µM 0.792427337038475 0.225125278210912 no 743 0.214055772423107 1072 7184 An antifungal and steroid mimetic. SGTC_390 dec-rvkr-cmk 16.7 µM 0.79189356470083 0.225280187857792 no 744 0.214211369805116 1086 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2338 7999974 200 µM 0.790607135238075 0.225653779129716 no 745 0.214586640899921 1120 315925 SGTC_728 3030-5151 22.5 µM 0.789190293693358 0.226065648645284 no 746 0.21500039707645 1021 3125388 SGTC_1825 st052143 62.6 µM 0.788925032360492 0.226142806126543 no 747 0.215077912037978 1019 674173 SGTC_1338 1486-1223 76 µM 0.787194466110276 0.226646547012597 no 748 0.215584018112887 1076 3444526 SGTC_3270 9137563 49.47 µM 0.786843240162772 0.226748860671798 no 749 0.2156868187827 1010 17015724 SGTC_862 0452-0056 10.2 µM 0.78478658583559 0.227348495931394 no 750 0.21628935314048 1032 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1118 chelidonine 707.474 nM 0.783567393157031 0.227704383413919 no 751 0.216646997415537 1124 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1215 3852-0577 11.2 µM 0.783142245292694 0.227828559572192 no 752 0.216771792878646 1133 2884876 SGTC_1945 st075991 56.6 µM 0.781826161691474 0.228213199547895 no 753 0.217158371903967 1019 1084980 SGTC_1665 st014639 11.4 µM 0.781286786190675 0.228370943404899 no 754 0.21731692003157 1133 981133 YIL048W NEO1 SGTC_3000 9075062 71.4286 µM 0.781146442317931 0.228411997922447 no 755 0.217358184731539 1004 17057871 SGTC_2448 5185112 27.17 µM 0.780472455040788 0.228609215866646 no 756 0.217556417313149 1008 5718189 SGTC_1905 st060207 84.5 µM 0.780225097627921 0.228681620029585 no 757 0.21762919603759 1040 1948547 SGTC_3055 9094636 49.47 µM 0.779121125657479 0.229004921373503 no 758 0.217954183369814 1079 25236176 SGTC_412 gemfibrozil 100 µM 0.77845334458658 0.229200607375657 no 759 0.218150900549739 1038 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1287 0971-0001 34.6 µM 0.777553120301296 0.229464556690552 no 760 0.218416253513051 1078 4665869 SGTC_145 3737-0113 38.366 µM 0.776128910161878 0.229882488441437 no 761 0.218836437677818 1152 6849351 SGTC_454 lyso-paf C-16 6.67 µM 0.775658151407023 0.230020725347574 no 762 0.218975427657596 1063 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1757 st041620 31.8375 µM 0.775081636301956 0.230190080641578 no 763 0.21914571099935 1100 5289815 SGTC_1781 st038725 66.3 µM 0.77411033780605 0.230475563963608 no 764 0.219432772307835 1086 4270275 YIL048W NEO1 SGTC_1750 st081859 2.357 µM 0.773540949623688 0.23064301007901 no 765 0.219601151884885 1139 5291695 SGTC_3052 9092717 49.47 µM 0.771882211438772 0.231131200306886 no 766 0.220092096975597 1073 25237534 SGTC_686 1319-0111 510 µM 0.769699112217464 0.231774595396537 no 767 0.220739198418166 1101 4562600 SGTC_1853 st056710 91.2 µM 0.768851250771522 0.232024742801325 no 768 0.220990809994683 1133 269167 SGTC_97 0535-0701 19.132 µM 0.768726272821789 0.232061628171819 no 769 0.221027912359378 1060 2832013 YGL099W LSG1 SGTC_2784 7567673 72.73 µM 0.766454236640508 0.232732754438734 no 770 0.221703035890657 1118 3471247 SGTC_148 3253-0744 288.01 µM 0.766395969332899 0.232749979923641 no 771 0.221720365194324 1107 6893655 SGTC_343 4130-2827 29.8 µM 0.766304456523795 0.232777035161089 no 772 0.221747583618269 1086 1118244 SGTC_2304 7443016 91.4 µM 0.766256179921797 0.232791308565847 no 773 0.221761943175308 1013 939854 SGTC_540 1187-0821 17.3 µM 0.76521451061302 0.233099405746904 no 774 0.222071910208885 1049 847520 SGTC_664 1222-0054 14.9 µM 0.764822827996945 0.233215313253509 no 775 0.222188526215317 1110 6813991 SGTC_2846 9008642 19.48 µM 0.763800204146298 0.233518080896703 no 776 0.222493157580778 1050 2992898 SGTC_2330 7979373 200 µM 0.763748574935252 0.233533372505683 no 777 0.22250854381804 1066 1863007 SGTC_2259 7964009 200 µM 0.763311843536258 0.233662746412514 no 778 0.222638720241217 1045 313134 SGTC_424 splitomicin 100 mM 0.759485793238158 0.234797842997003 no 779 0.223781004675999 1021 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1107 amlodipine 47 µM 0.758984725340823 0.234946723127329 no 780 0.223930847063012 1026 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2452 5863136 48.41 µM 0.758238982372019 0.235168399058214 no 781 0.224153964103618 1099 2184096 SGTC_2037 5169046 200 µM 0.753247288315996 0.236655175964544 no 782 0.225650663858203 1089 5718022 SGTC_2417 cerulenin 830 nM 0.752186806099411 0.236971705422421 no 783 0.225969363460928 1102 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3323 9138564 53.9225 µM 0.751796630200019 0.237088222452588 no 784 0.226086684412324 1156 43912313 YNL103W MET4 SGTC_3158 9100007 49.47 µM 0.750704519522992 0.237414523420851 no 785 0.226415251235318 1101 19297233 SGTC_2962 9082311 13.18 µM 0.750702926809327 0.237414999472024 no 786 0.226415730607826 1103 16459453 SGTC_2897 9048598 12.99 µM 0.749358976990806 0.237816883578213 no 787 0.226820434796721 1113 6467404 SGTC_209 4077-0173 175.592 µM 0.748068942970044 0.238202995812962 no 788 0.227209286874718 1032 15993494 SGTC_931 2812-0076 566 µM 0.747489692864993 0.23837647930626 no 789 0.227384011095758 1157 3450959 SGTC_2556 citropten 84.59 µM 0.744140448130526 0.239380922400108 no 790 0.228395755594829 1139 2775 A potential DNA crosslinker. SGTC_236 1509-0011 5.31 µM 0.743249460263418 0.239648519634955 no 791 0.228665331814661 1225 3107280 SGTC_3093 9117344 49.47 µM 0.742386718751418 0.239907788931936 no 792 0.228926532029385 1065 24824913 SGTC_1331 1472-0049 76.2 µM 0.741005518924506 0.240323182570972 no 793 0.229345047018211 1117 24051409 SGTC_1146 3579-1023 7 µM 0.740571545457795 0.240453780252849 no 794 0.22947663307136 1158 X1146 SGTC_429 1112-0049 25.5 µM 0.739719666171596 0.240710252669257 no 795 0.229735056265413 1054 2836170 SGTC_2086 5274770 176.623 µM 0.738845619362766 0.240973553656094 no 796 0.230000373433399 1109 689278 SGTC_3082 9117008 49.47 µM 0.73848839363171 0.241081210687911 no 797 0.230108858754342 1115 41448529 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.738439923748708 0.241095820059347 no 798 0.230123580702407 1160 3256 An antibiotic and ribosome inhibitor. SGTC_680 0417-1641 114 µM 0.738438801709565 0.241096158260347 no 799 0.230123921510007 1085 2835990 SGTC_2865 9030313 51.95 µM 0.737661914893151 0.241330386593433 no 800 0.230359960490269 1072 42562754 SGTC_2068 5226020 147 µM 0.737202543833523 0.241468943316855 no 801 0.230499593358526 1189 1810509 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.735989877639642 0.241834918417436 no 802 0.230868429000632 1068 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3155 9099265 49.47 µM 0.735419715410316 0.242007093791453 no 803 0.231041959195828 1049 25236499 SGTC_328 k915-0120 63.5 µM 0.734656472489802 0.242237678949991 no 804 0.231274367861489 1114 6624543 SGTC_55 0767-0285 6.563 µM 0.731643677994506 0.243149043233558 no 805 0.232193040740931 1132 3116166 SGTC_2371 9071574 200 µM 0.730087781939634 0.243620423604947 no 806 0.232668264593654 1125 45596039 SGTC_2817 7995342 71.43 µM 0.729343705035494 0.243846026370991 no 807 0.23289572207327 1114 18879975 SGTC_1044 1222-0021 1.78 µM 0.72930636788666 0.243857349896715 no 808 0.232907138950743 1079 4306703 SGTC_1912 st060209 90.8 µM 0.728738824821845 0.244029508003907 no 809 0.233080719390058 1122 688787 SGTC_2704 st078022 71.1 µM 0.72813521985073 0.244212677020979 no 810 0.233265407992083 1148 54697681 SGTC_2293 7624732 200 µM 0.727257323622171 0.24447921428294 no 811 0.233534168026384 1149 894453 SGTC_1356 1502-0781 85.8 µM 0.726672754415218 0.244656781686422 no 812 0.233713223837949 1101 567702 SGTC_2720 fluspirilene 36.88 µM 0.725578651918316 0.244989310302097 no 813 0.234048556091999 1107 3396 An atypical antipsychotic. SGTC_2718 lomofungin 53.02 µM 0.724381323958926 0.245353490518708 no 814 0.234415831170313 1165 5351222 A RNA synthesis inhibitor. SGTC_3210 9128157 49.47 µM 0.722544190168652 0.245912839834047 no 815 0.234979983403884 1079 17590849 SGTC_548 1436-0017 110 µM 0.721555721183167 0.246214080394244 no 816 0.235283835374744 1209 9677137 SGTC_714 4296-0578 26.1 µM 0.721182377148256 0.246327910200523 no 817 0.235398656461735 1158 1589775 SGTC_889 0919-1524 82.7 µM 0.720119128075647 0.246652241405786 no 818 0.235725825623841 1137 3905452 SGTC_1855 st056195 39.6 µM 0.719621048406505 0.246804253180695 no 819 0.235879174418777 1127 4028379 SGTC_1523 st012844 44.7 µM 0.719552026893433 0.246825322205793 no 820 0.235900429103184 1151 4274103 SGTC_2661 dactinomycin 12.96 µM 0.718251089844418 0.247222617200312 no 821 0.236301240826101 1167 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1226 3909-7979 35.4 µM 0.7168724941745 0.247644001368601 no 822 0.236726387657637 1171 6615510 SGTC_1519 esterone 74 µM 0.716376234206879 0.247795782979693 no 823 0.236879532803859 1147 698 A steroid. SGTC_1008 4106-0037 6 µM 0.716089837698541 0.247883400237192 no 824 0.236967939156339 1141 2905394 SGTC_1594 piperine 70.1 µM 0.71548598774743 0.248068190171932 no 825 0.237154398092453 1154 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1728 st035614 33.7865 µM 0.715425944331214 0.248086568651765 no 826 0.237172942917023 1145 15945546 SGTC_100 0086-0128 49.5915 µM 0.715199154287617 0.248155992577648 no 827 0.237242995778117 1154 93297 SGTC_2885 9057732 51.95 µM 0.714851633943099 0.248262394009072 no 828 0.237350362900902 1191 6471414 SGTC_2703 st077852 53.4 µM 0.714692185714683 0.248311220930101 no 829 0.237399633685828 1144 6281836 SGTC_1800 st050079 29.0735 µM 0.714475979405278 0.24837743673108 no 830 0.237466452143063 1173 3645560 SGTC_2414 st077232 92.9 µM 0.708301365681698 0.250272453026984 no 831 0.239379064600215 1119 729801 SGTC_223 busulfan 5 mM 0.708298733801278 0.250273262394049 no 832 0.239379881626155 1142 2478 A DNA alkylator. SGTC_2930 9013230 14.89 µM 0.707035243625449 0.250661976475931 no 833 0.239772288129798 1154 2995857 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.705413989940977 0.251161224896425 no 834 0.240276320158701 1215 66535 A nucleotide analog. SGTC_103 0844-0104 51.839 µM 0.704491667606448 0.251445479115546 no 835 0.240563318653068 1240 5375804 SGTC_2253 7938677 135.83 µM 0.703745407677271 0.251675596329793 no 836 0.240795668446762 1200 2301972 SGTC_380 3970-0968 6 µM 0.703557518853382 0.251733551376477 no 837 0.240854187312926 1157 2891601 SGTC_2792 7535235 81.82 µM 0.703290670193693 0.251815874005628 no 838 0.240937311890486 1159 1281891 SGTC_2803 7707263 71.43 µM 0.703193729150021 0.251845783770463 no 839 0.24096751333236 1163 2199229 SGTC_1702 st027038 51 µM 0.702560983234803 0.252041054482733 no 840 0.241164692365409 1198 5521182 SGTC_3191 9110352 49.47 µM 0.701567616970998 0.252347776740074 no 841 0.24147442632897 1165 17122424 SGTC_3141 9094609 49.47 µM 0.700847078556611 0.252570380853546 no 842 0.241699227047389 1146 25236309 YDL196W YDL196W SGTC_191 3914-0123 66.505 µM 0.69983779922082 0.252882362830828 no 843 0.242014302929545 1117 3144412 SGTC_341 1486-1430 230 µM 0.699037504147357 0.253129889040601 no 844 0.24226429656025 1171 2054753 YPL210C SRP72 SGTC_1678 st019265 80.2 µM 0.698020366570126 0.253444667081071 no 845 0.242582228639394 1203 5367020 SGTC_3057 9095946 49.47 µM 0.695125019670922 0.254341827786088 no 846 0.243488478215501 1227 24540043 SGTC_96 0929-0093 37.281 µM 0.694971710843227 0.254389378874045 no 847 0.24353651512772 1165 6991579 SGTC_2755 lomerizine 42.69 µM 0.694354114137119 0.254580983161197 no 848 0.243730081186431 1213 3949 A calcium channel blocker. SGTC_2727 riluzole 51.77 µM 0.694243415408923 0.254615334516622 no 849 0.243764784960022 1199 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2197 6588183 93.1375 µM 0.694068132773735 0.254669732122008 no 850 0.243819741081533 1186 884136 SGTC_2428 5615643 7.78 µM 0.693923536103179 0.254714611157283 no 851 0.243865081308071 1205 2253075 SGTC_1364 1653-0028 37.6 µM 0.692433773989334 0.255177235479944 no 852 0.244332481029407 1171 5718652 SGTC_769 0302-0231 76 µM 0.692128602559136 0.255272056297011 no 853 0.244428285421258 1212 571869 YER009W NTF2 SGTC_1649 st011737 51.3 µM 0.690554962893415 0.255761299279978 no 854 0.244922629186586 1175 1761035 SGTC_1900 st060200 72.8 µM 0.690454844449867 0.255792442557321 no 855 0.244954098625327 1221 688945 SGTC_978 1416-0512 87.4 µM 0.688164749866874 0.256505349461568 no 856 0.245674519617285 1229 6814003 SGTC_3283 9109332 35.8195 µM 0.685688694676227 0.257277308880227 no 857 0.246454718679272 1109 17027281 SGTC_516 3992-2719 87.3 µM 0.684838794568375 0.257542560245553 no 858 0.246722825925616 1177 5350887 YDR037W KRS1 SGTC_1065 prochlorperazine maleate 2.48 µM 0.684750582015179 0.257570099262228 no 859 0.246750662168248 1257 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1975 st070967 30.8 µM 0.682965410965694 0.258127739054591 no 860 0.247314349675106 1222 261391 SGTC_1182 1222-0449 220 µM 0.68162556840357 0.258546680964495 no 861 0.247737871587645 1191 658318 SGTC_2106 5357045 167.29 µM 0.681306571632197 0.258646476732921 no 862 0.24783876296273 1222 668842 SGTC_471 1-acyl-paf 4 µM 0.68011395871431 0.259019753393672 no 863 0.248216153330787 1176 16759367 SGTC_804 1595-0054 20.9 µM 0.679723815784801 0.259141924921516 no 864 0.248339676627382 1211 761523 Stimulates phospholipase C. SGTC_445 e6 berbamine 66 µM 0.677861727154453 0.259725439854998 no 865 0.248929684353445 1267 6610268 A calcium/calmodulin antagonist. SGTC_882 0843-0131 351 µM 0.67760790542101 0.259805031394872 no 866 0.249010166180536 1251 5425421 SGTC_3159 9100096 49.47 µM 0.675780261123327 0.260378501890869 no 867 0.249590084402942 1196 25236875 SGTC_3293 9120939 62.045 µM 0.675420534476218 0.260491452146897 no 868 0.249704311431265 1231 934087 SGTC_1630 st005209 31.3 µM 0.674933857318254 0.2606443036309 no 869 0.249858894300308 1234 3367314 SGTC_2970 9090938 41.86 µM 0.67370492728663 0.261030481041222 no 870 0.250249464330494 1239 17217104 SGTC_2299 7976368 114.88 µM 0.672358509078787 0.261453915228026 no 871 0.250677744997534 1228 2979718 SGTC_2581 avocatin a 64 µM 0.671346339292827 0.261772463918485 no 872 0.250999960380101 1246 6710728 A skin care supplement. SGTC_1037 k284-1091 78.7 µM 0.671247920588886 0.261803448736052 no 873 0.251031302798953 1215 3334711 SGTC_1977 st070720 65.3 µM 0.669817923234421 0.262253861970635 no 874 0.25148693326224 1225 682188 SGTC_3305 9127027 53.8275 µM 0.66946878433113 0.26236389221245 no 875 0.251598243384523 1177 41905295 SGTC_1030 k029-0042 36.7 µM 0.668728435090967 0.26259728959215 no 876 0.251834362640766 1245 6080581 SGTC_2775 cyproheptadine 69.59 µM 0.668650618349241 0.262621827729376 no 877 0.251859187492126 1250 2913 A selective serotonin reuptake inhibitor. SGTC_2092 5303694 80.6725 µM 0.668260181985129 0.262744962661309 no 878 0.2519837627667 1232 1963699 SGTC_1080 nisoldipine 24.4 µM 0.667422395380329 0.263009281530943 no 879 0.252251182344395 1223 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2664 lyso-paf C-16 73.48 µM 0.667295569283193 0.263049306581201 no 880 0.252291677983625 1244 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_979 1426-2828 121 µM 0.666075721773614 0.263434437173546 no 881 0.252681350893713 1300 747872 SGTC_2811 7967822 32.47 µM 0.664738693940541 0.263856894367516 no 882 0.253108820181173 1258 2232244 SGTC_215 1287-0124 461.5 µM 0.664074586867839 0.264066858859299 no 883 0.253321287196679 1253 5560863 SGTC_2607 solasodine 47.35 µM 0.663153399385837 0.264358242920699 no 884 0.253616156807122 1261 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2710 st078562 53.7235 µM 0.662674965783624 0.264509642495066 no 885 0.253769373205963 1220 17250908 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.661667486623537 0.264828601930219 no 886 0.254092173124965 1218 2333 A French combination drug. SGTC_1768 st044301 37.178 µM 0.661437067130656 0.264901578267899 no 887 0.254166030604784 1254 3931349 SGTC_1897 st060201 15 µM 0.66045107410238 0.265213968287312 no 888 0.254482202866037 1244 611878 SGTC_2028 5153890 36.43 µM 0.658679388400483 0.265775757242008 no 889 0.255050835728001 1234 2830968 YPR165W RHO1 SGTC_3130 9127414 49.47 µM 0.657809559259111 0.2660517944979 no 890 0.255330255541399 1272 1494646 SGTC_3241 9133421 49.47 µM 0.657525583135309 0.266141944765143 no 891 0.255421513327074 1264 17018221 SGTC_1955 wogonin 32.4 µM 0.657457799759811 0.266163465372607 no 892 0.255443298525551 1317 5281703 A flavanone. SGTC_73 0327-0325 16.231 µM 0.656955432951993 0.266322989739703 no 893 0.255604786671176 1282 53298 SGTC_1974 st069448 26.9 µM 0.655209693765609 0.266877717486567 no 894 0.256166376969194 1231 6323587 YNR016C ACC1 SGTC_721 1187-1332 279 µM 0.654075985827551 0.267238277984281 no 895 0.256531426013766 1208 25730 SGTC_1076 itraconazole 331 nM 0.653453877387514 0.267436235580737 no 896 0.256731857321475 1268 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1204 4049-0315 18.3 µM 0.653221936947749 0.267510058954381 no 897 0.256806604903824 1324 588402 SGTC_323 4013-0906 34.3 µM 0.652174042632714 0.267843716983015 no 898 0.257144451563505 1287 2910086 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.649930646236319 0.268558736650741 no 899 0.257868510659443 1231 17037758 SGTC_710 3448-4187 58 µM 0.647863361994591 0.269218473830034 no 900 0.258536664713703 1300 3946412 SGTC_1452 4194-0072 190 µM 0.64774881707241 0.26925505257154 no 901 0.258573712262165 1326 1343545 SGTC_1456 k015-0012 13 µM 0.645768232541325 0.269887925767412 no 902 0.259214732080866 1327 2989616 SGTC_1385 3091-4834 14.1 µM 0.645244585237181 0.270055375668623 no 903 0.259384348676837 1260 4072814 SGTC_1129 3453-1384 223 µM 0.644961310039544 0.270145981971911 no 904 0.259476129319694 1356 1084452 SGTC_1216 1165-0504 9.65 µM 0.644625547902931 0.270253396046904 no 905 0.2595849373526 1271 6304004 SGTC_2771 fluoxetine 41.05 µM 0.643906646765618 0.270483452376929 no 906 0.25981798569266 1292 3386 A selective serotonin reuptake inhibitor. SGTC_2451 5856223 45.7 µM 0.643441946347561 0.270632213712271 no 907 0.259968686444894 1256 2179896 SGTC_1305 1181-0477 144 µM 0.64213112707845 0.271052057306791 no 908 0.260394023436383 1306 6252086 SGTC_903 1134-0042 114 µM 0.640392240626079 0.271609507831396 no 909 0.26095881307256 1273 701009 SGTC_339 3091-4833 71.4 µM 0.639828942402821 0.271790211762344 no 910 0.261141907106225 1249 3240077 SGTC_2849 9019321 12.99 µM 0.639598186868512 0.271864254532098 no 911 0.261216930771458 1271 16489627 SGTC_1501 4491-0275 38.4 µM 0.638718387198419 0.272146648814887 no 912 0.261503074440418 1262 5104718 SGTC_3079 9117512 49.47 µM 0.6386146421044 0.272179958073575 no 913 0.2615368268186 1312 7185044 SGTC_1292 0kpi-0043 232 µM 0.638057578052587 0.272358848314502 no 914 0.261718100001645 1271 3333905 SGTC_2805 7950783 58.44 µM 0.637528108941294 0.272528931100699 no 915 0.261890453300288 1294 1178958 YDL195W SEC31 SGTC_3172 9105863 49.47 µM 0.636920783822428 0.272724088695955 no 916 0.2620882220117 1262 2348785 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.63585126120881 0.273067937136627 no 917 0.262436686221128 1295 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_988 1497-1057 103 µM 0.635701359680563 0.273116147209839 no 918 0.262485545011473 1295 3533044 SGTC_2682 pyrogallin 40.03 µM 0.63345327830902 0.273839661881498 no 919 0.263218841100565 1292 822798 An ATP competetive kinase inhibitor. SGTC_1673 st016611 27.3 µM 0.631399363766438 0.274501513996419 no 920 0.263889715959223 1351 5226799 SGTC_1597 7-benzyloxygramine 47.5 µM 0.631138244587253 0.274585713392832 no 921 0.263975068331355 1286 260807 SGTC_1930 st074634 34.3 µM 0.629845447829103 0.275002770808989 no 922 0.264397853688742 1265 684253 YOR116C RPO31 SGTC_2593 nobiletin 86.24 µM 0.62970286008637 0.275048788845828 no 923 0.26444450547758 1247 72344 An anti-infammatory. SGTC_1236 0330-0013 258 µM 0.626755889187365 0.276000727538043 no 924 0.265409631110168 1279 4617066 SGTC_782 0083-0095 30.5 µM 0.626709004036573 0.276015885574739 no 925 0.265425000313108 1305 3591729 An indicator and reagent. SGTC_3011 9081274 71.4286 µM 0.626660813413818 0.276031466098422 no 926 0.265440797927373 1295 6625322 SGTC_585 0kpi-0023 191 µM 0.626612875389153 0.276046965383008 no 927 0.265456513209507 1284 64601 SGTC_2203 7227154 166.4 µM 0.626006406402651 0.276243085352383 no 928 0.26565536965127 1289 896304 SGTC_2058 5236698 133 µM 0.625000505780434 0.276568524217001 no 929 0.26598536307133 1301 766665 SGTC_873 0591-4978 488 µM 0.624366770861267 0.276773652828597 no 930 0.266193371248248 1430 3305145 SGTC_2812 7970281 58.44 µM 0.623925103847284 0.27691665656658 no 931 0.266338386456643 1354 2233435 SGTC_2060 5238662 140 µM 0.623659480711989 0.27700267792042 no 932 0.266425619358326 1285 790130 SGTC_1497 4476-2978 41.3 µM 0.623049633769016 0.277200224727014 no 933 0.266625952966509 1318 1528379 SGTC_887 0885-0007 9.62 µM 0.622000615723114 0.277540192727015 no 934 0.266970731570836 1353 5719458 SGTC_1206 3978-0017 132 µM 0.621280334116781 0.277773741042717 no 935 0.267207595365283 1385 3873677 SGTC_1286 0929-0070 131 µM 0.61934962525236 0.278400238337235 no 936 0.267843029559699 1373 1420408 SGTC_1562 morin hydrate 59.1 µM 0.618758310405388 0.278592252224221 no 937 0.268037795038472 1340 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1546 5-methoxyflavanone 78.7 µM 0.615630033512041 0.279609149393143 no 938 0.269069362271299 1361 147795 SGTC_1898 st060199 18.6 µM 0.615426295071034 0.279675440323258 no 939 0.269136615230766 1315 688866 SGTC_2558 carylophyllene oxide 100 µM 0.614522697364811 0.279969538259642 no 940 0.269434989571832 1365 6708694 An oxygenated terpenoid and antifungal agent. SGTC_912 3474-0017 2.18 µM 0.613071102731997 0.280442308870158 no 941 0.269914663267828 1397 3360550 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.611667582497637 0.280899789284972 no 942 0.270378857060837 1383 6710655 SGTC_1430 4049-0248 69.1 µM 0.611618755831434 0.280915710931834 no 943 0.270395012945936 1385 22774488 SGTC_2120 5538279 151.968 µM 0.611425615147975 0.280978695500149 no 944 0.270458924529882 1365 2058197 SGTC_2322 7413319 38.22 µM 0.611055422032914 0.281099437214391 no 945 0.270581445080923 1353 1840400 SGTC_1690 st023502 41.2 µM 0.608785593934041 0.281840308918724 no 946 0.271333281820829 1328 24207482 SGTC_2592 piperlongumine 83.33 µM 0.608624352579833 0.281892973858479 no 947 0.271386729484759 1284 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3243 9134147 49.47 µM 0.608388766868984 0.281969929808742 no 948 0.271464829960528 1373 24282180 SGTC_3107 9121808 49.47 µM 0.607880836764687 0.282135883646934 no 949 0.271633255094043 1289 662681 SGTC_2529 gangaleoidin 93.61 µM 0.606645255956568 0.282539775900725 no 950 0.27204317986254 1376 4565183 SGTC_342 k048-0088 23.3 µM 0.606065411057177 0.282729414019328 no 951 0.272235659181818 1311 6820570 SGTC_2597 laccaic acid a 100 µM 0.606040077382406 0.282737700785018 no 952 0.272244070229414 1316 5491415 A textile dye. SGTC_1929 genistein trimethyl ether 50.5 µM 0.605457810899456 0.282928195082238 no 953 0.27243742443783 1340 136420 SGTC_960 1222-0186 7.7 µM 0.604976220321983 0.283085798801262 no 954 0.272597398544918 1370 3126296 SGTC_3332 9141069 11.198 µM 0.603981975936329 0.283411305103289 no 955 0.272927812734657 1300 17332883 SGTC_277 nystatin 15.5 µM 0.603914793772178 0.283433306384897 no 956 0.272950146338405 1306 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_909 3448-9333 149 µM 0.603545065829053 0.28355440210802 no 957 0.273073072516295 1319 3344074 SGTC_2196 6573537 42.6665 µM 0.600168752351474 0.284661379769156 no 958 0.274196888161744 1392 2903087 SGTC_3077 9117319 49.47 µM 0.599315651502144 0.284941408503129 no 959 0.274481206313124 1343 17154678 SGTC_1842 st055362 61.2 µM 0.599060261108804 0.285025265461617 no 960 0.274566350121512 1371 676032 SGTC_3282 9108498 15.4605 µM 0.596882682396027 0.285740746849829 no 961 0.275292855041856 1317 16459645 SGTC_3124 9127567 49.47 µM 0.596670680442458 0.285810449392624 no 962 0.275363635698451 1348 17592030 SGTC_1822 st052468 42 µM 0.596129222468814 0.285988508014965 no 963 0.275544451792599 1323 2873678 SGTC_480 am 92016 50 µM 0.595981861272924 0.286036976915264 no 964 0.27559367213737 1272 2129 K+ channel blocker. SGTC_1432 4049-0298 68.4 µM 0.59578122857514 0.286102973738919 no 965 0.27566069272968 1384 741646 SGTC_521 r062-0005 13.8 µM 0.59398112761411 0.286695428662957 no 966 0.2762623678325 1329 2832033 SGTC_2871 9038510 12.99 µM 0.592866693414854 0.287062506076482 no 967 0.276635184792363 1422 4945164 SGTC_1108 betulinic acid 729.144 nM 0.591540274552853 0.287499697847269 no 968 0.27707923913164 1346 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_54 0159-0055 9 µM 0.59068952614018 0.28778027278987 no 969 0.277364233517703 1446 3319099 SGTC_754 3474-0146 171 µM 0.58922471603676 0.288263666784866 no 970 0.277855269592388 1283 24762078 SGTC_329 k048-0121 21.3 µM 0.587952414868707 0.288683842468211 no 971 0.278282116601366 1360 6832902 SGTC_877 0771-0151 33.1 µM 0.587716848485459 0.288761669571594 no 972 0.278361182324427 1402 6166523 SGTC_2662 daunorubicin 22.37 µM 0.58743040528133 0.28885631881357 no 973 0.278457339140274 1318 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3081 9117243 49.47 µM 0.586905500443835 0.289029800664223 no 974 0.278633587712548 1433 45595589 SGTC_451 chloral hydrate 100 µM 0.58511520125194 0.289621865625746 no 975 0.279235129102718 1407 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_417 st075190 100 µM 0.583252360561726 0.290238524329985 no 976 0.279861713752797 1432 222757 SGTC_2980 9014342 25.29 µM 0.582125706113916 0.290611780530202 no 977 0.280241005629414 1360 2996599 SGTC_1142 3253-1408 9.78 µM 0.582123085774466 0.290612648900084 no 978 0.280241888065365 1363 256655 SGTC_254 nsc-64875 3.808 µM 0.581401497102472 0.290851826645698 no 979 0.280484944350051 1481 56993 SGTC_2450 5739737 12.93 µM 0.580407835505948 0.29118133618442 no 980 0.2808198112122 1363 2262825 SGTC_3228 9131799 49.47 µM 0.579185018758613 0.291587075255201 no 981 0.281232169153937 1396 17015818 SGTC_966 1300-0360 30.2 µM 0.578542201607453 0.291800472097491 no 982 0.281449056967401 1370 70588 SGTC_3001 9076041 71.4286 µM 0.578048972021579 0.291964259480302 no 983 0.281615528334333 1359 16004211 SGTC_1766 st045414 44.774 µM 0.578047255346892 0.291964829613422 no 984 0.281616107817163 1374 253960 SGTC_547 1120-0019 610 nM 0.576087977552609 0.292615872492503 no 985 0.282277858620557 1389 3676939 SGTC_1450 4112-4260 37.6 µM 0.575144068101908 0.292929762044177 no 986 0.282596933172228 1379 1633175 SGTC_3249 9135183 49.47 µM 0.574715480919568 0.293072336853996 no 987 0.28274186790403 1401 4902779 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.574353472380452 0.293192788527537 no 988 0.282864315644551 1352 2346 DNA damaging agent; causes G2/M arrest. SGTC_1591 genipin 88.4 µM 0.568816775719954 0.295037875622845 no 989 0.284740244416915 1426 442424 A DNA cross-linking agent. SGTC_1315 1237-0019 3.69 µM 0.568009710220671 0.2953072737423 no 990 0.285014187256488 1420 825140 SGTC_1570 verbenone 133 µM 0.566790948241061 0.295714310377207 no 991 0.285428110564249 1430 29025 A natural terpanoid with antifungal properties. SGTC_841 0251-0215 91.2 µM 0.565591263334458 0.296115227343345 no 992 0.285835834152641 1411 3888614 SGTC_532 1548-0774 215 µM 0.565323777922746 0.296204651008603 no 993 0.285926779194653 1500 5932993 SGTC_591 4299-0174 154 µM 0.564506829569701 0.296477843561467 no 994 0.286204626770541 1396 5509088 SGTC_1769 st044406 64.4 µM 0.563885967956855 0.296685540694184 no 995 0.286415870140113 1400 670903 SGTC_2168 5727979 200 µM 0.562587161469614 0.29712024639379 no 996 0.286858018172055 1323 695210 SGTC_2189 6047310 154.431 µM 0.561913498369003 0.29734583356499 no 997 0.287087478206466 1339 711535 SGTC_740 k014-0057 261 µM 0.561119946872092 0.297611667665702 no 998 0.287357885514414 1463 4012779 SGTC_890 0929-0006 47.2 µM 0.559966131007622 0.297998381157572 no 999 0.287751269835782 1351 1378169 SGTC_2234 tolnaftate 200 µM 0.55979083778524 0.298057152554698 no 1000 0.287811056918854 1387 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2375 9072683 200 µM 0.559644402785509 0.298106252566123 no 1001 0.287861005854731 1495 16798029 SGTC_870 0573-2213 57.6 µM 0.558879403207362 0.298362818674689 no 1002 0.288122013524858 1378 3916321 SGTC_1863 st057641 20.1 µM 0.556858208713339 0.299041171428693 no 1003 0.288812154919605 1390 3921635 SGTC_1588 farnesol 29.9 µM 0.556703176174219 0.299093232313016 no 1004 0.288865123246071 1397 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1409 3909-8004 61.9 µM 0.556098999053032 0.299296157972622 no 1005 0.289071589663784 1398 2119279 SGTC_2394 5221648 200 µM 0.551711290737069 0.300771732506714 no 1006 0.290573086532586 1545 788586 SGTC_949 1165-0505 146 µM 0.548857702603144 0.301733144501528 no 1007 0.291551553660946 1394 6244267 SGTC_2721 ifenprodil 61.44 µM 0.548388769681575 0.301891266363612 no 1008 0.291712492991742 1457 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3044 9093193 49.47 µM 0.546570261003964 0.302504810339297 no 1009 0.292337002463697 1369 25236277 SGTC_844 0330-0132 15.3 µM 0.544796897175982 0.303103660732816 no 1010 0.292946606472386 1441 2828079 SGTC_2876 9059903 25.97 µM 0.5446545891623 0.303151739956482 no 1011 0.292995551227602 1397 6916095 SGTC_2488 5268135 45.7 µM 0.541835288456537 0.304104952039503 no 1012 0.293965989559593 1492 1270356 YLR208W SEC13 SGTC_1715 st032160 10.2275 µM 0.537819553328787 0.305464982258139 no 1013 0.295350815690456 1438 5289825 SGTC_838 0109-0203 71.4 µM 0.535796281426986 0.306151234473293 no 1014 0.296049676230413 1423 759422 SGTC_2659 sanguinarine 24.21 µM 0.535311949985567 0.306315610816857 no 1015 0.296217082200843 1408 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2934 9036370 36.88 µM 0.534442184030589 0.306610896924405 no 1016 0.296517820023488 1529 6462800 SGTC_414 piperonyl butoxide 100 µM 0.533677039582376 0.3068707678041 no 1017 0.296782498621463 1394 5794 A potent inhibitor of cytochrome P450. SGTC_789 1309-1135 70.6 µM 0.532309351324901 0.307335526274561 no 1018 0.29725587828036 1405 3092424 SGTC_1476 4112-3294 3.34 µM 0.531600198258088 0.307576627738371 no 1019 0.297501463718836 1506 704369 SGTC_2695 st077686 51.995 µM 0.531222858688643 0.30770495146103 no 1020 0.297632177212003 1397 2876092 SGTC_795 0685-0265 78 µM 0.531130996209371 0.307736195147811 no 1021 0.297664003088036 1450 302754 SGTC_152 4469-0003 551.229 µM 0.529222202008623 0.308385717401025 no 1022 0.298325658409369 1448 697280 SGTC_1367 1812-0510 76.9 µM 0.528805480728105 0.30852759872752 no 1023 0.298470197680865 1451 1142582 YDR527W RBA50 SGTC_1027 k015-0025 8.67 µM 0.528597922443177 0.308598276882223 no 1024 0.298542200906055 1394 3598955 SGTC_1373 2887-0003 58.5 µM 0.528221371686535 0.30872651878797 no 1025 0.29867284880822 1445 776948 SGTC_668 1682-0499 62.6 µM 0.526371330960952 0.309356925868565 no 1026 0.299315115467403 1457 682214 SGTC_470 aa-861 153 µM 0.525988264715123 0.309487527106863 no 1027 0.299448180345215 1407 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2947 9072639 7.68 µM 0.524671605243957 0.309936607714379 no 1028 0.299905749828163 1396 16488146 SGTC_280 3448-3607 3.04 µM 0.524343862682831 0.310048436880889 no 1029 0.300019697087921 1442 626179 SGTC_2666 tannic acid 100 µM 0.524090858843346 0.310134776438843 no 1030 0.300107673101877 1472 16134267 A thiamine antagonist. SGTC_1091 telmisartan 47.6 µM 0.523823482161419 0.310226032220159 no 1031 0.300200659605871 1518 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3286 9117135 37.221 µM 0.522284041552499 0.310751671203822 no 1032 0.300736289359711 1396 3438150 SGTC_2364 9055074 200 µM 0.521253320782621 0.311103824892698 no 1033 0.301095157049822 1413 6470630 SGTC_3120 9124077 49.47 µM 0.521244030399021 0.311106999810973 no 1034 0.301098392574878 1460 18774327 YGL155W CDC43 SGTC_2171 5739187 198.077 µM 0.520429947022122 0.311385261201922 no 1035 0.301381970981542 1388 2262761 SGTC_743 1275-0778 158 µM 0.520145064481257 0.311482662215279 no 1036 0.301481235568239 1529 2849257 YMR203W TOM40 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.519412487289174 0.311733190096239 no 1037 0.301736562594533 1426 688669 SGTC_2005 4024620 188 µM 0.518412432961756 0.312075330909803 no 1038 0.302085270969344 1430 236743 SGTC_2388 9080168 200 µM 0.518194134715288 0.312150037165912 no 1039 0.302161413314357 1403 15943073 SGTC_2965 9082772 38.63 µM 0.517299383786763 0.31245632047021 no 1040 0.302473592075594 1529 16459634 SGTC_1612 st002233 45.4 µM 0.517053624829845 0.312540469221221 no 1041 0.302559362728073 1476 1035021 SGTC_2772 vinpocetine 57.06 µM 0.516927471497393 0.312583668372878 no 1042 0.302603394873461 1498 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_726 3448-4391 34.2 µM 0.516102964696128 0.312866070674434 no 1043 0.302891248713568 1563 1356692 SGTC_2326 6164455 177.58 µM 0.515934283456234 0.312923859325018 no 1044 0.302950154223597 1461 2888790 SGTC_3269 9137823 49.47 µM 0.514791938896864 0.313315337050173 no 1045 0.303349209489817 1416 17682936 SGTC_1776 st049249 45.9 µM 0.514502367879437 0.313414605537971 no 1046 0.303450402652842 1430 1822314 SGTC_407 eburnamonine 100 µM 0.512990531256384 0.313933101021937 no 1047 0.303978972092542 1423 3195 SGTC_1828 st055811 49 µM 0.511974068092874 0.314281911265512 no 1048 0.304334579301171 1467 5877589 SGTC_1539 benzyladenosine 56 µM 0.51016541990681 0.314902978421831 no 1049 0.304967788092053 1441 92208 A nucleotide analog. SGTC_1572 epiandrosterone 68.9 µM 0.510064966252428 0.314937488319548 no 1050 0.305002974123927 1462 441302 A steroid. SGTC_2109 5483026 200 µM 0.509816899675579 0.315022716154371 no 1051 0.305089872448533 1500 759335 SGTC_759 3486-0358 89.3 µM 0.508963438652071 0.315316013600028 no 1052 0.3053889258467 1604 875103 SGTC_3238 9133470 49.47 µM 0.507997371292647 0.315648149431077 no 1053 0.305727593359833 1549 3534688 SGTC_1590 st077108 57.8 µM 0.506631510062502 0.316117989306661 no 1054 0.306206697451756 1495 5489485 SGTC_2134 5324836 1.464 µM 0.505641761354257 0.316458636693478 no 1055 0.306554079566841 1524 699272 SGTC_317 4495-0002 170 µM 0.504655320196708 0.316798300706 no 1056 0.306900473820727 1441 15991618 SGTC_105 0111-0055 734.78 µM 0.504401872466557 0.316885596021997 no 1057 0.30698950125047 1464 5179370 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.504333032744201 0.316909308333791 no 1058 0.307013684231951 1400 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2468 5987765 72.9 µM 0.504071668553083 0.316999343859281 no 1059 0.307105507548882 1526 26772094 SGTC_212 3807-4682 38.772 µM 0.503519342841708 0.317189646329541 no 1060 0.307299592204031 1578 3125501 YBL034C STU1 SGTC_2872 9044037 25.97 µM 0.497165943853729 0.319382160832092 no 1061 0.309536017562251 1556 6465195 SGTC_819 1013-0258 27.7 µM 0.496966670890936 0.319451031345893 no 1062 0.309606277345774 1476 5753198 SGTC_1049 3226-0134 66 µM 0.496548691695913 0.319595508916709 no 1063 0.309753671308867 1496 5702385 SGTC_2250 alverine citrate 130 µM 0.496222200744813 0.319708381956813 no 1064 0.309868824626968 1454 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.493893005975924 0.320514105124492 no 1065 0.310690872123373 1394 641818 YHR062C RPP1 SGTC_158 k038-0087 26.446 µM 0.493175332762146 0.320762535936582 no 1066 0.310944352850702 1528 X158 SGTC_29 0299-0004 12.984 µM 0.493131697330091 0.320777643432128 no 1067 0.310959767691818 1432 16871 A napthoquinone isolated from Swertia calycina. SGTC_1787 fluconazole 80 µM 0.492415256016144 0.32102573276758 no 1068 0.311212908259594 1421 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_3353 9151644 39.2805 µM 0.488830922205898 0.322268114313266 no 1069 0.312480702006164 1494 4909158 SGTC_911 3456-4043 236 µM 0.488196237636331 0.322488312676373 no 1070 0.312705424623487 1595 914281 SGTC_2447 5741742 33.78 µM 0.487860375104969 0.322604862504881 no 1071 0.312824371573167 1572 1776504 SGTC_1920 st075728 45.7 µM 0.487590406980431 0.322698558527845 no 1072 0.312919995907482 1594 3400306 SGTC_981 1488-1094 54.9 µM 0.486837198331933 0.322960029100397 no 1073 0.313186853480871 1458 3449522 SGTC_1406 3909-7906 11.9 µM 0.486728446761383 0.322997788602972 no 1074 0.313225391637045 1526 X1406 SGTC_2309 7664088 163.95 µM 0.486168141047776 0.32319236058454 no 1075 0.313423978785221 1560 704922 SGTC_557 1315-0110 16.2 µM 0.485143903412533 0.323548162770742 no 1076 0.313787135474404 1443 6833801 SGTC_645 0845-0943 5.41 µM 0.483593061544394 0.324087205135574 no 1077 0.314337349962128 1489 1885106 SGTC_2514 salinomycin 42.74 µM 0.481643417423303 0.324765386880452 no 1078 0.315029638821711 1640 23682228 A polyether potassium ionophore. SGTC_63 0099-0242 26.702 µM 0.480653649988155 0.325109899090433 no 1079 0.315381339152922 1509 3898502 YLR359W ADE13 SGTC_583 1488-1091 88.9 µM 0.480358276280139 0.325212739960074 no 1080 0.315486328599377 1567 4303273 SGTC_1 0258-0098 57.368 µM 0.480263293152702 0.325245813259888 no 1081 0.31552009315194 1476 6790032 YDR047W HEM12 SGTC_137 0438-0332 85.389 µM 0.47989115175008 0.325375406841903 no 1082 0.31565239662064 1469 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3279 9140807 49.47 µM 0.479117637378654 0.325644841084979 no 1083 0.31592747153185 1505 45595718 SGTC_3234 9132280 49.47 µM 0.478180576579655 0.325971364649094 no 1084 0.31626084291118 1505 17612295 SGTC_2689 tacrolimus 100 µM 0.476736420270123 0.326474849562467 no 1085 0.316774912504595 1520 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1470 k295-0292 231 µM 0.476718319850466 0.326481162029634 no 1086 0.316781357874943 1571 5045612 SGTC_1659 st012954 42.1 µM 0.47524692246068 0.326994473527068 no 1087 0.317305492989208 1543 24207262 SGTC_2020 4017018 200 µM 0.474719465851299 0.327178561763098 no 1088 0.317493470728035 1512 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1178 0988-0033 191 µM 0.474549749207836 0.327237803707266 no 1089 0.317553965243276 1550 5392207 SGTC_109 0132-0036 33.701 µM 0.473133872964146 0.327732204404316 no 1090 0.31805883588576 1464 67274 A color developer. SGTC_1055 3448-0672 86 µM 0.473100783434013 0.327743762340376 no 1091 0.318070638940636 1517 748378 SGTC_607 4491-0986 66.8 µM 0.473016657020991 0.327773147837484 no 1092 0.318100647713709 1619 698981 YDR232W HEM1 SGTC_198 3454-2873 16.191 µM 0.472655765686611 0.327899219885268 no 1093 0.318229394981905 1523 710957 SGTC_2280 7785178 200 µM 0.472175297081637 0.328067094922384 no 1094 0.318400835286904 1544 2954328 SGTC_1697 st025554 27.742 µM 0.472083035419254 0.328099334990752 no 1095 0.318433760449571 1511 1269519 SGTC_2019 4016004 108 µM 0.47115689786723 0.328423036953002 no 1096 0.318764347994473 1466 45595336 SGTC_2735 sertaconazole 140 nM 0.470609265777491 0.32861450498536 no 1097 0.318959894789412 1576 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_3051 9093778 49.47 µM 0.470266174798584 0.328734482457404 no 1098 0.31908243035207 1521 17217378 SGTC_2786 7743617 45.45 µM 0.467095804873849 0.329843981415552 no 1099 0.320215667739762 1430 583674 SGTC_1902 st060212 70.5 µM 0.466555870921372 0.330033085695598 no 1100 0.320408832807705 1501 688944 SGTC_1326 1431-2094 10.8 µM 0.46561764954344 0.330361787846673 no 1101 0.320744603658561 1496 616278 SGTC_459 nigericin 15.3 µM 0.462649148761525 0.331402651881981 no 1102 0.321807936654418 1551 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_774 k060-0086 136 µM 0.462262481063597 0.331538327730157 no 1103 0.321946550840473 1644 5911235 SGTC_2223 6903751 107.57 µM 0.461336579174483 0.331863302523398 no 1104 0.322278572535562 1555 5598863 SGTC_3325 9138760 55.175 µM 0.461275996317899 0.331884570422205 no 1105 0.322300302055014 1490 43844959 SGTC_878 0828-0289 13.7 µM 0.461130586412336 0.331935619468886 no 1106 0.322352459342742 1523 745350 YLR208W SEC13 SGTC_3156 9099931 49.47 µM 0.458403465618964 0.332893606685657 no 1107 0.323331301147146 1587 18111053 SGTC_727 3032-0951 202 µM 0.458103288066822 0.332999120335874 no 1108 0.323439118382156 1566 3652836 SGTC_504 lovastatin 124 µM 0.457119680361032 0.333344955127869 no 1109 0.323792512686942 1496 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1424 4048-1941 275 µM 0.454854872320608 0.334141796222745 no 1110 0.324606825337114 1652 X1424 SGTC_1446 4239-0190 62 µM 0.454800745055212 0.334160849313422 no 1111 0.324626297099616 1523 1340085 SGTC_1718 roemerine 11.9335 µM 0.454623374101325 0.334223287844716 no 1112 0.324690107951068 1517 235224 An aporphine alkaloid with mutagenic activity. SGTC_3118 9124250 49.47 µM 0.454556527580969 0.33424682050097 no 1113 0.324714157944071 1513 1504786 SGTC_2057 5236571 38.335 µM 0.454514405564274 0.334261649474904 no 1114 0.324729312948268 1639 54684039 YBR257W POP4 SGTC_773 4358-1457 44.6 µM 0.452620929621013 0.334928510852875 no 1115 0.325410862580188 1699 1186886 SGTC_1309 pyrazolanthrone 13.4 µM 0.449782031388773 0.335929314891597 no 1116 0.32643380770271 1649 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_801 0866-0028 10.1 µM 0.449205365265709 0.336132750993771 no 1117 0.32664175873275 1563 6849771 SGTC_2365 9042475 200 µM 0.448280382721976 0.336459166293747 no 1118 0.326975428312303 1539 6464479 SGTC_1675 st018485 24.5 µM 0.44774399386765 0.33664850801287 no 1119 0.327168983633509 1562 3323024 SGTC_2096 5468907 200 µM 0.446115484406124 0.337223614685038 no 1120 0.327756914117948 1671 759785 SGTC_682 0kpi-0099 17 µM 0.445659256624611 0.337384799423916 no 1121 0.327921699826194 1544 1714895 YML126C ERG13 SGTC_637 1181-0519 7.26 µM 0.445122835822738 0.337574354438105 no 1122 0.328115493449674 1548 6252091 YGR060W ERG25 SGTC_1196 1588-0294 184 µM 0.44506009114355 0.337596529218355 no 1123 0.32813816434691 1522 6144269 SGTC_299 1273-0059 1.44 µM 0.445005214505458 0.337615923793491 no 1124 0.328157992883815 1574 2848077 SGTC_1998 st075797 76.8 µM 0.444187239219082 0.337905064819546 no 1125 0.328453608691973 1631 24208315 SGTC_2810 7959871 45.46 µM 0.443179105096129 0.338261555524521 no 1126 0.328818095570564 1645 2974535 SGTC_1604 st002052 72.4 µM 0.442865515911922 0.338372474753958 no 1127 0.328931505718861 1586 6254834 YHR062C RPP1 SGTC_8 0354-0001 70 µM 0.44109853517127 0.33899773319234 no 1128 0.329570831963746 1590 4993152 SGTC_1560 lithocholic acid 53.1 µM 0.440029918888274 0.339376085969658 no 1129 0.329957719058823 1602 9903 A bile acid which acts as a detergent. SGTC_515 4092-1064 102 µM 0.439671609587171 0.339502984737425 no 1130 0.330087483874004 1699 717353 SGTC_1067 clotrimazole 1.36 µM 0.438798117343703 0.3398124168563 no 1131 0.330403912295058 1570 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1167 k781-0610 148 µM 0.438673056063728 0.339856728296302 no 1132 0.330449226513934 1577 4525169 SGTC_1307 1187-1599 12.2 µM 0.438231261884195 0.340013281559082 no 1133 0.330609324402042 1549 1538471 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.437802756858975 0.34016515206407 no 1134 0.330764636165787 1609 279621 SGTC_78 0336-0123 156.75 µM 0.436934806710061 0.340472849902979 no 1135 0.33107931419816 1517 6765896 SGTC_2081 5214970 32.255 µM 0.436073591993175 0.340778264949164 no 1136 0.33139166825373 1659 2063512 SGTC_3144 9087057 49.47 µM 0.43533525012917 0.341040188374397 no 1137 0.331659550960881 1719 17249618 SGTC_2260 7964312 200 µM 0.432907656648532 0.341901905705174 no 1138 0.33254092866651 1678 231951 SGTC_3098 9119039 49.47 µM 0.432415018130414 0.342076877232685 no 1139 0.332719902429258 1574 17161528 SGTC_3074 9116018 49.47 µM 0.432161195434612 0.342167041250674 no 1140 0.332812130167712 1609 17027303 SGTC_1238 0333-0287 48.8 µM 0.431213151830859 0.34250388902654 no 1141 0.333156695950978 1560 7226 SGTC_2588 indole-3-carbinol 100 µM 0.428939193440579 0.343312355654161 no 1142 0.33398373830699 1709 3712 Induces cell cycle arrest. SGTC_543 3844-1095 191 µM 0.427753196769281 0.343734301253608 no 1143 0.334415407682346 1668 4230703 SGTC_1982 st072467 71.9 µM 0.426942164847024 0.344022956673762 no 1144 0.334710726597046 1561 3163533 SGTC_828 2074-0507 139 µM 0.4265307832696 0.344169406789404 no 1145 0.334860560991601 1677 X828 SGTC_1412 3909-8563 178 µM 0.424996193406109 0.344715920414658 no 1146 0.335419724843816 1704 23767530 SGTC_2466 5983409 37.09 µM 0.423898455791709 0.345107056800968 no 1147 0.335819935194909 1581 2879657 SGTC_1281 0884-0031 11.8 µM 0.422082804167548 0.345754357281359 no 1148 0.336482289436745 1562 1548255 SGTC_1222 0366-0074 1.18 µM 0.420231417441978 0.346414862337173 no 1149 0.337158202803393 1717 286520 SGTC_597 k018-0003 82.8 µM 0.419729715057254 0.34659393141158 no 1150 0.337341457451431 1681 6786234 SGTC_600 1495-0418 41.6 µM 0.419042792381791 0.346839165450572 no 1151 0.337592429297972 1599 5377768 SGTC_1737 st035557 69.7 µM 0.418940005964831 0.346875866119527 no 1152 0.337629989227711 1545 5716916 SGTC_908 3448-7491 47.7 µM 0.418674421589981 0.346970701684061 no 1153 0.33772704582732 1561 1203031 SGTC_1503 4585-0012 61.3 µM 0.418165942047733 0.347152297633979 no 1154 0.337912897466524 1660 2922052 SGTC_3101 9120531 49.47 µM 0.417543805086367 0.347374532396081 no 1155 0.338140345177344 1686 24824904 SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.417225831058253 0.347488136791798 no 1156 0.338256616462635 1683 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_155 k072-0202 43.6 µM 0.416826883440481 0.347630690460625 no 1157 0.338402518598475 1586 5857737 SGTC_2045 5106652 78.05 µM 0.415630536274538 0.348058303470767 no 1158 0.338840189128582 1671 673349 SGTC_764 1951-2361 146 µM 0.412084559800899 0.349326883317797 no 1159 0.340138722654301 1550 5438930 SGTC_3296 9122258 64.045 µM 0.409691543784296 0.35018394265276 no 1160 0.341016117008408 1627 4730474 SGTC_1020 4335-0961 93.3 µM 0.409293844461968 0.350326452884288 no 1161 0.341162016150627 1536 669075 SGTC_992 3909-8734 162 µM 0.407924074391683 0.350817452848573 no 1162 0.34166470879263 1594 4288319 SGTC_1043 0916-0009 19.3 µM 0.407142657142427 0.351097666927772 no 1163 0.341951607432059 1798 3101130 SGTC_397 arbidol 50 µM 0.40695214375129 0.351165996791172 no 1164 0.342021568587043 1699 131410 A RNA synthesis inhibitor. SGTC_307 1501-1223 22.3 µM 0.406854128821649 0.351201152870659 no 1165 0.342057564168572 1619 2830329 SGTC_1774 st048371 48.465 µM 0.405600188688804 0.351651029458367 no 1166 0.342518195099615 1584 4242727 SGTC_2090 5301565 104.445 µM 0.405414576416589 0.351717639319294 no 1167 0.34258639910458 1622 2056344 SGTC_2726 cimetidine 79.27 µM 0.404709582019091 0.351970679029116 no 1168 0.342845498994171 1640 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1811 st050069 61.5 µM 0.404402313395317 0.352080985767705 no 1169 0.342958449652015 1660 3877702 SGTC_544 k015-0020 52.4 µM 0.404257851025069 0.352132850792963 no 1170 0.343011558265016 1637 3008304 SGTC_1635 st007035 42.4 µM 0.403584945734303 0.352374474159128 no 1171 0.343258978883155 1621 3716403 SGTC_2095 5432005 200 µM 0.402494697014563 0.352766081511485 no 1172 0.343659995156724 1605 783734 SGTC_278 4092-0821 23.9 µM 0.402185051919564 0.352877331665726 no 1173 0.343773921207777 1673 877900 SGTC_41 0478-0632 82.643 µM 0.401650999288311 0.353069237140861 no 1174 0.343970445648075 1730 3750424 SGTC_126 0417-1624 672.48 µM 0.401318605476525 0.353188697786965 no 1175 0.344092783547746 1734 41912 YDL195W SEC31 SGTC_3110 9122132 49.47 µM 0.400906113208924 0.353336965528652 no 1176 0.344244624462427 1715 918317 SGTC_1160 4092-0570 10.5 µM 0.400066840959132 0.353638705346738 no 1177 0.344553643189359 1567 4994975 SGTC_1767 st044992 70.3 µM 0.398948250803669 0.354041010064803 no 1178 0.344965667628114 1557 9600693 SGTC_1121 fusaric acid 630.51 nM 0.398920210086539 0.354051097099165 no 1179 0.344975998584309 1607 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1439 4092-1168 46 µM 0.3979497296928 0.354400269255418 no 1180 0.345333620891394 1652 2886240 SGTC_2075 5212009 200 µM 0.395013060776637 0.355457607114301 no 1181 0.346416624535509 1704 780898 SGTC_507 nimesulide 162 µM 0.394150739467391 0.355768294871342 no 1182 0.346734876036061 1735 4495 A COX2 inhibitor. SGTC_1609 st001574 46.4 µM 0.392779902940286 0.356262393958016 no 1183 0.347241024664034 1599 3960012 SGTC_1336 1486-0901 104 µM 0.392093559385356 0.356509867760189 no 1184 0.347494543080078 1671 5006114 SGTC_1927 st060202 13.8 µM 0.390375840302421 0.357129487654963 no 1185 0.348129325086296 1746 688887 SGTC_2575 plumbagin 510 nM 0.390292148602338 0.357159686777144 no 1186 0.34816026419269 1568 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2013 4024628 200 µM 0.388613293136644 0.357765669942 no 1187 0.348781115880917 1675 5230760 SGTC_181 1447-1644 8.07 µM 0.388190273016675 0.357918415757901 no 1188 0.348937615445971 1741 534600 SGTC_606 k015-0008 38.6 µM 0.387168434748659 0.358287479064991 no 1189 0.349315758395271 1761 1970475 SGTC_3222 9128301 49.47 µM 0.387070001840354 0.358323037652935 no 1190 0.349352192526412 1622 4911358 SGTC_1462 k081-0014 26.5 µM 0.386292630383746 0.358603903866581 no 1191 0.349639978923025 1546 3270634 SGTC_1687 st020778 55.3625 µM 0.384606521317274 0.359213361916607 no 1192 0.350264480905544 1671 4259299 SGTC_1347 1493-0251 600 nM 0.384016108203642 0.359426856422233 no 1193 0.350483254273739 1755 3986378 SGTC_375 3970-0961 9.27 µM 0.383748249012954 0.359523729292594 no 1194 0.350582523948598 1665 2898222 SGTC_2850 9015429 58.44 µM 0.383160512916175 0.359736319180703 no 1195 0.35080037702095 1599 6457570 SGTC_82 0054-0107 293.755 µM 0.383089738413576 0.359761921939192 no 1196 0.350826613947761 1765 3104697 SGTC_1941 st076221 61.8 µM 0.380654852216291 0.360643127406587 no 1197 0.351729686891078 1778 2828568 SGTC_2325 6158266 200 µM 0.380447480586725 0.360718211200018 no 1198 0.351806637545571 1635 3623240 SGTC_189 3970-0742 2.116 µM 0.379080102000664 0.361213437200777 no 1199 0.352314190919942 1766 2891807 SGTC_1681 tripelennamine 100 µM 0.378856137061667 0.361294573190468 no 1200 0.352397348932564 1602 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_422 cantharidin 155 µM 0.377774919972594 0.361686354434042 no 1201 0.352798903215839 1581 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_829 1635-0120 117 µM 0.376934199274338 0.361991091569873 no 1202 0.35311125270167 1763 285054 SGTC_2583 asiatic acid 100 µM 0.369419889300801 0.364718679460914 no 1203 0.355907387649035 1694 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2251 lansoprazole 556 µM 0.368602637451264 0.365015746474706 no 1204 0.356211964699742 1615 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2517 totarol 10 µM 0.368233550475843 0.365149934342597 no 1205 0.356349547763934 1611 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_319 1348-1596 45.5 µM 0.364855365732492 0.366378896438283 no 1206 0.357609686902551 1794 5380505 SGTC_3209 9113616 49.47 µM 0.362032609187792 0.367406849846992 no 1207 0.358663831171456 1871 16649353 SGTC_783 0848-0141 92.7 µM 0.361468851015885 0.367612265851448 no 1208 0.358874493191031 1657 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_18 0111-0177 500 nM 0.35986803454822 0.368195760077194 no 1209 0.359472911235937 1711 721752 SGTC_1322 1348-1070 12 µM 0.357571178350117 0.369033490355924 no 1210 0.36033212521523 1738 6758089 SGTC_320 4092-0846 5.34 µM 0.356971903607588 0.369252165846993 no 1211 0.360556419764097 1754 1359356 SGTC_1165 k072-0275 30.3 µM 0.355672218810724 0.369726566444587 no 1212 0.361043026245383 1731 6153523 YGL055W OLE1 SGTC_203 k066-0004 30.888 µM 0.355533621993055 0.369777167668113 no 1213 0.361094930661399 1846 6795412 SGTC_1244 0416-0015 52.5 µM 0.355443923638419 0.369809917432249 no 1214 0.361128523998899 1693 96201 SGTC_3215 9129942 49.47 µM 0.354873690728555 0.370018137230492 no 1215 0.361342109549321 1824 17682944 SGTC_1788 fluconazole 20 µM 0.35375850241279 0.370425456862771 no 1216 0.361759937620956 1659 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.35353230266897 0.370508093472523 no 1217 0.361844708100254 1730 6708739 YPR165W RHO1 SGTC_31 0508-1974 57.237 µM 0.352881362209096 0.370745932165627 no 1218 0.362088691965396 1750 6810525 SGTC_272 doxorubicin 8.13 µM 0.352612355555418 0.370844235448958 no 1219 0.36218953673552 1700 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3182 9108849 49.47 µM 0.351929712342127 0.371093732048973 no 1220 0.36244548782013 1729 17133045 SGTC_1521 st012942 49.4 µM 0.351479515923055 0.371258302240167 no 1221 0.362614318676854 1874 24207259 SGTC_2942 9052777 62.25 µM 0.351439800853211 0.371272821292927 no 1222 0.36262921374602 1714 6469503 SGTC_2732 terfenadine 20 µM 0.351215284541981 0.371354903509666 no 1223 0.362713422114478 1730 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1779 st039427 55 µM 0.349762212855814 0.371886281718198 no 1224 0.363258579867114 1892 1124498 SGTC_2458 5808907 16.39 µM 0.348845315335239 0.372221710460894 no 1225 0.363602720567723 1819 2731747 SGTC_719 2810-4230 27.3 µM 0.348442961944393 0.372368934084885 no 1226 0.363753771318367 1718 721079 SGTC_2539 epi(13)torulosol 80 µM 0.347097161425831 0.372861506354477 no 1227 0.364259162976138 1648 6708597 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.344476569452016 0.373821257139472 no 1228 0.365243956946498 1686 61125 An anti-inflammatory. SGTC_3354 9151612 71.43 µM 0.341382363181632 0.374955469362422 no 1229 0.366407875322511 1820 27261949 SGTC_2793 7325131 81.82 µM 0.340905388026353 0.375130405893239 no 1230 0.366587404239188 1755 4176441 SGTC_283 0987-0079 11.7 µM 0.339620234004567 0.375601879768183 no 1231 0.367071269202866 1807 411556 SGTC_1184 1269-1718 139 µM 0.339494184652554 0.375648132474267 no 1232 0.36711873860937 1823 5403821 SGTC_16 erodoxin 22.806 µM 0.338523243947914 0.376004470520259 no 1233 0.367484456914149 1731 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3239 9133757 49.47 µM 0.33795847628656 0.376211790551003 no 1234 0.367697239823923 1776 17036923 SGTC_2442 5158906 48.48 µM 0.337873445849139 0.376243007390134 no 1235 0.367729279568425 1814 1893835 SGTC_1719 st032227 49.2 µM 0.336775865687605 0.376646029627842 no 1236 0.368142933885873 1649 3125804 SGTC_2880 9042983 58.44 µM 0.335534003291492 0.377102193242571 no 1237 0.368611149453278 1714 6464714 SGTC_2361 9034121 116 µM 0.333080291668317 0.37800399982301 no 1238 0.369536837888456 1716 6496917 SGTC_2357 9067248 200 µM 0.332955914018674 0.378049729787652 no 1239 0.369583780857331 1756 9150235 SGTC_2683 piperine 63.03 µM 0.331913110863498 0.378433204671896 no 1240 0.369977435026919 1735 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_69 0096-0274 206.684 µM 0.331812047767561 0.378470375448437 no 1241 0.370015593205513 1808 6741392 SGTC_2455 5377712 9.75 µM 0.331790471306806 0.378478311367246 no 1242 0.370023739949767 1641 2243908 SGTC_2420 aureobasidin a 50 nM 0.331155333959296 0.378711940672252 no 1243 0.370263578401769 1873 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2104 5389443 200 µM 0.330471908723815 0.378963381735992 no 1244 0.370521707512464 1811 2244536 SGTC_1621 st003705 32.4 µM 0.329577075516544 0.3792926799868 no 1245 0.370859773361007 1857 24207032 SGTC_1058 3448-5425 97.3 µM 0.327905144646706 0.379908184431932 no 1246 0.371491691874306 1779 7279705 SGTC_338 4055-0136 114 µM 0.327873523968918 0.379919828201924 no 1247 0.371503646484879 1700 2900563 SGTC_1666 st014829 29 µM 0.327660275237553 0.379998356216497 no 1248 0.371584271191167 1712 3858230 SGTC_2426 5582046 32.21 µM 0.326752394787024 0.380332734992326 no 1249 0.371927584048113 1776 2251934 SGTC_2433 5607874 27.82 µM 0.326331199068897 0.380487894736538 no 1250 0.372086892823398 1697 2252428 SGTC_1627 st003713 25.6 µM 0.324627868559754 0.381115562153348 no 1251 0.372731366276577 1710 16195070 YER133W GLC7 SGTC_3026 9090633 49.47 µM 0.324169066371135 0.381284681660435 no 1252 0.372905020036568 1700 25236842 SGTC_227 fluconazole 33.516 µM 0.321439168958942 0.382291419494331 no 1253 0.373938802086034 1714 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3039 9090270 49.47 µM 0.320355901155427 0.382691130531353 no 1254 0.374349275558659 1887 17173750 SGTC_1859 st055998 20 µM 0.31945904143699 0.383022154126391 no 1255 0.374689222823353 1892 676301 SGTC_58 0957-0393 9 µM 0.317034426368403 0.383917486858792 no 1256 0.375608740079735 1731 6997992 SGTC_1445 4239-0156 97.7 µM 0.315135547568431 0.384619115183673 no 1257 0.376329369739849 1877 4008346 SGTC_853 0419-0306 21 µM 0.315014689109648 0.384663784736081 no 1258 0.376375250478874 1707 762713 SGTC_2368 9071271 200 µM 0.314992334497068 0.384672047217924 no 1259 0.376383737011752 1694 27209959 SGTC_1581 himbacine 57.9 µM 0.314261786307991 0.384942093729194 no 1260 0.376661109562043 1715 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1969 st069479 40.1 µM 0.313541749234134 0.385208309439118 no 1261 0.376934553600837 1842 3895485 SGTC_898 1000-0849 28.3 µM 0.313304987976732 0.385295857822864 no 1262 0.377024480457969 1864 6751807 SGTC_1345 1488-0192 31.4 µM 0.312213581234652 0.385699508227179 no 1263 0.377439105653626 1862 658348 SGTC_1655 st012546 55.1 µM 0.311282036653253 0.386044132502689 no 1264 0.377793111042085 1781 720985 YLR208W SEC13 SGTC_368 fentichlor 4.58 µM 0.310760004510087 0.386237297276101 no 1265 0.377991538499965 1712 7329 A pesticide. SGTC_1419 3993-2473 62.6 µM 0.309294271425103 0.386779805290159 no 1266 0.378548844114106 1793 704026 SGTC_1720 st037298 9.481 µM 0.308892198920358 0.386928662077157 no 1267 0.378701765592892 1730 597396 SGTC_2412 st077135 33.4 µM 0.308818950989061 0.386955781992085 no 1268 0.37872962625098 1831 13258915 SGTC_1152 3909-8331 15.9 µM 0.308388649195283 0.38711511159851 no 1269 0.37889330900302 1758 16001939 SGTC_1899 st063254 59.6 µM 0.307235497274541 0.387542187602239 no 1270 0.379332064170868 1689 3093813 SGTC_509 pifithrin 175 µM 0.307130906215921 0.387580930202519 no 1271 0.379371867031027 1813 4817 A p53 inhibitor. SGTC_399 oxolinic acid 75 µM 0.307109090478382 0.387589011325029 no 1272 0.379380169323971 1763 4628 A DNA gyrase inhibitor. SGTC_2018 5133068 143 µM 0.306968090315529 0.387641242665275 no 1273 0.379433830306945 1744 785362 SGTC_531 3788-1495 174 µM 0.306939963826477 0.387651661933558 no 1274 0.379444534792695 1733 2896655 SGTC_1756 st041558 35.5 µM 0.302417128375829 0.389328163460694 no 1275 0.381167049555799 1941 3955792 SGTC_1394 3474-0001 65.7 µM 0.302139288332956 0.389431219332384 no 1276 0.381272941689457 1741 5017666 YIL048W NEO1 SGTC_2164 5685496 200 µM 0.301843543197637 0.389540925069393 no 1277 0.381385667691099 1861 759046 SGTC_555 4296-0685 37 µM 0.300390429707844 0.390080080720911 no 1278 0.381939681401672 1808 2908540 YHR072W ERG7 SGTC_2219 9098279 200 µM 0.299813991377046 0.390294018048845 no 1279 0.382159521212398 1879 902349 SGTC_1801 st050089 28.441 µM 0.298772852193935 0.390680507004232 no 1280 0.38255668307444 1790 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2384 9036245 200 µM 0.29830209260632 0.390855296631445 no 1281 0.382736303644364 1864 6462766 SGTC_678 1218-2179 85.9 µM 0.296870556821557 0.391386950860634 no 1282 0.38328266779771 1813 6820081 YOR116C RPO31 SGTC_2894 9048625 32.47 µM 0.296428339259075 0.391551225934469 no 1283 0.383451492851764 1904 4092861 SGTC_1014 4130-3005 69.3 µM 0.295723729198989 0.391813014580417 no 1284 0.383720536999048 1750 743608 SGTC_2387 9077560 195.08 µM 0.293975156640453 0.39246288524407 no 1285 0.384388443574542 1763 5303272 SGTC_1140 3229-1848 2.98 µM 0.293824659771811 0.392518832628243 no 1286 0.384445945312087 1893 2849525 SGTC_1045 1348-1485 165 µM 0.293782211433509 0.392534613248539 no 1287 0.384462164403076 1806 6810614 SGTC_1952 st077036 64.1 µM 0.29287321701881 0.39287258393321 no 1288 0.384809530692067 1864 2937007 SGTC_723 4182-0001 115 µM 0.292354719365972 0.393065401299576 no 1289 0.385007712630586 1755 744821 YLR208W SEC13 SGTC_2418 pentamidine 31.67 µM 0.292136596890566 0.393146523880947 no 1290 0.385091093126615 1818 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2421 5690543 90.72 µM 0.291974374423403 0.393206859532253 no 1291 0.385153108475044 1806 3397993 SGTC_1636 st007707 68.9 µM 0.291370043298106 0.393431651902762 no 1292 0.38538416153538 1900 403051 SGTC_2620 irigenin 100 µM 0.289561687550345 0.394104515898394 no 1293 0.386075790350441 1873 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1371 2421-0008 32.7 µM 0.2882748181173 0.394583534790244 no 1294 0.386568190785062 1791 2827552 SGTC_288 1315-0019 35.1 µM 0.28738183086487 0.394916030379635 no 1295 0.386909985794555 1814 6811474 SGTC_3274 9138298 49.47 µM 0.28712874190227 0.395010279658725 no 1296 0.387006872733647 1868 17015756 SGTC_2997 9067075 71.4286 µM 0.286112555478481 0.395388765065833 no 1297 0.387395957733537 1854 27209819 SGTC_2546 rhodinyl acetate 100 µM 0.28589389581211 0.395470219231854 no 1298 0.387479694573923 1930 6708682 SGTC_139 0099-0334 718.624 µM 0.284470533298692 0.396000555625003 no 1299 0.388024906328697 1932 97690 SGTC_784 4579-0127 173 µM 0.283893835570174 0.396215484632705 no 1300 0.388245870365514 1943 1948547 SGTC_751 0833-0568 350 µM 0.28166431625253 0.397046698571372 no 1301 0.389100459288892 1831 6954252 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.281177953420049 0.397228087653315 no 1302 0.389286956716201 1775 4174840 SGTC_3183 9108214 49.47 µM 0.280503477402812 0.397479670355589 no 1303 0.389545628965669 1902 4974831 SGTC_3037 9091026 49.47 µM 0.280259333176708 0.397570747810801 no 1304 0.389639274218733 1861 25236398 YIL048W NEO1 SGTC_1917 st066507 28.5 µM 0.280044426790916 0.397650922776502 no 1305 0.389721710153672 1765 3156428 SGTC_1922 5578187 25 µM 0.278692434487902 0.398155408565305 no 1306 0.390240434490999 1916 1350412 SGTC_568 1193-0097 7.48 µM 0.278387684837155 0.398269147161541 no 1307 0.390357386047626 1882 3646150 SGTC_2951 9072950 58.06 µM 0.277405336566463 0.398635837755342 no 1308 0.390734442189695 1910 16488155 SGTC_1246 0422-0085 105 µM 0.275900726286053 0.39919765154432 no 1309 0.391312158030884 1944 264295 SGTC_2213 7173844 200 µM 0.275898810967649 0.399198366847767 no 1310 0.391312893596891 1826 892728 SGTC_3072 9116419 49.47 µM 0.275328446703874 0.39941139270471 no 1311 0.391531955693119 1777 17170162 SGTC_948 3448-0295 75.3 µM 0.275284470882377 0.399427818517969 no 1312 0.391548847093091 1794 678569 SGTC_2642 cholecalciferol 100 µM 0.275102564275069 0.399495766017759 no 1313 0.391618720779922 1892 9821465 A vitamin D precursor, similar to steriods. SGTC_2240 6690706 185.951 µM 0.274596427006033 0.399684839275661 no 1314 0.391813155844572 1721 805876 SGTC_1777 st045864 34.765 µM 0.274211391020809 0.399828689547787 no 1315 0.391961087370859 1825 4691462 SGTC_3022 9087993 49.47 µM 0.273803092905847 0.399981245454228 no 1316 0.392117973312907 1865 17173644 SGTC_2007 4011539 71.82 µM 0.27375705010719 0.399998449775971 no 1317 0.392135666065054 1773 45595301 SGTC_2808 7946468 45.46 µM 0.272612658015019 0.400426124855277 no 1318 0.392575490345791 1860 2970879 SGTC_479 n-linoleoylglycine 10 µM 0.27228027321862 0.40055036403092 no 1319 0.392703261556377 1827 6433346 An anti-infammatory. SGTC_1883 5-benzylidenerhodanine 20 µM 0.271824743623207 0.4007206487549 no 1320 0.392878389333621 1949 1273210 SGTC_1353 1498-1206 8.11 µM 0.27142108961832 0.400871557267746 no 1321 0.393033591729278 1816 6756808 SGTC_3272 9137413 49.47 µM 0.271149729871298 0.400973015081926 no 1322 0.393137937384653 1749 17614870 SGTC_762 1165-0429 115 µM 0.270967874430236 0.401041012160353 no 1323 0.393207870348229 1943 5967793 SGTC_2569 tetrandrine 100 µM 0.270881593912577 0.401073274125126 no 1324 0.393241050942064 1749 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1830 st055982 50.3 µM 0.270210203183436 0.401324343217897 no 1325 0.393499271781081 1950 455313 An antimicrobial agent. SGTC_3301 9125354 19.7965 µM 0.267052143337895 0.402505856574517 no 1326 0.394714506926892 1793 41905162 SGTC_1957 st077035 62.4 µM 0.26623255351517 0.402812632789942 no 1327 0.395030056680984 1895 705593 SGTC_2099 5377090 177.372 µM 0.266216119772966 0.402818784627358 no 1328 0.395036384530444 1812 2243829 SGTC_2471 5466956 24.79 µM 0.264821893080731 0.403340789481313 no 1329 0.395573335302518 1871 724419 SGTC_441 propafenone 146 µM 0.264161748996387 0.403588010599712 no 1330 0.395827642152584 1836 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1059 3448-6867 171 µM 0.263735218088723 0.403747765083932 no 1331 0.395991977951895 1999 3934407 SGTC_2017 5132927 60.65 µM 0.260719624243049 0.404877693546222 no 1332 0.397154365682812 1792 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2731 amoxapine 43.43 µM 0.260633678373624 0.404909908723908 no 1333 0.397187507736529 1955 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1812 st052057 4.327 µM 0.259800549113143 0.405222224783443 no 1334 0.397508813682351 1812 3645418 SGTC_3201 9113999 49.47 µM 0.25878020745372 0.40560480357495 no 1335 0.397902414989668 1893 16649224 SGTC_2602 kawain 100 µM 0.258226280940515 0.405812537032498 no 1336 0.398116138147287 1945 5369129 SGTC_1048 3161-0300 24.5 µM 0.257209643549767 0.406193865247037 no 1337 0.398508469957781 1838 2165101 SGTC_2026 5148700 152 µM 0.255951628604003 0.406665854392883 no 1338 0.398994094079011 1833 79838 SGTC_2446 5162541 200 µM 0.253639959853228 0.407533512421242 no 1339 0.399886861192639 1811 1549321 SGTC_3200 9114385 49.47 µM 0.253341671868066 0.407645504500124 no 1340 0.40000209833118 1800 17018030 YLR208W SEC13 SGTC_2335 9018011 154.17 µM 0.252928623614541 0.407800595726456 no 1341 0.400161685004558 1964 6458208 SGTC_413 propylparaben 100 µM 0.250544523833041 0.408696058422096 no 1342 0.401083138652941 1825 7175 A pharmaceutical preservative. SGTC_2937 9044753 11.33 µM 0.250257183084569 0.408804015273843 no 1343 0.401194233016051 1854 6465530 YGL099W LSG1 SGTC_3334 9142812 21.919 µM 0.250175691171054 0.408834633877257 no 1344 0.401225741635083 1930 45283678 SGTC_3246 9135460 32.98 µM 0.249916237240288 0.40893212108264 no 1345 0.401326063044714 1931 41446951 SGTC_476 mead acid 10 µM 0.249714227632789 0.409008028062431 no 1346 0.401404177325927 1868 5312531 An omega 9 fatty acid. SGTC_337 1315-0038 354 µM 0.246978132073203 0.410036476292117 no 1347 0.402462573995852 1867 1626437 SGTC_2021 4019055 173 µM 0.246403145239293 0.410252682281215 no 1348 0.402685085868688 1907 44827708 YER133W GLC7 SGTC_993 3909-8757 62.7 µM 0.244274499624778 0.411053330493352 no 1349 0.403509115850708 1870 4288324 YLR208W SEC13 SGTC_363 0455-0021 3.06 µM 0.244001913352237 0.411155885304475 no 1350 0.403614669029724 1858 4597466 SGTC_2816 7982706 58.44 µM 0.243126343348708 0.411485341014373 no 1351 0.403953762163758 1845 2981853 SGTC_1705 st027868 56.3335 µM 0.242287463255041 0.411801049760989 no 1352 0.404278713650371 1981 292948 SGTC_2170 morpholine 200 µM 0.241066231768377 0.41226075675665 no 1353 0.404751892106432 1958 121171 Reacts with secondary amines. SGTC_90 0870-0863 4.608 µM 0.24104309224925 0.412269468307926 no 1354 0.404760859093522 1826 1738164 SGTC_2685 mycophenolic acid 18.85 µM 0.240903786303379 0.412321915034113 no 1355 0.404814843753441 1943 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_134 0269-0018 6.916 µM 0.239230959773636 0.412951832688787 no 1356 0.405463248553388 1845 4378915 SGTC_1803 st050068 52.4 µM 0.237794258790349 0.413493014208236 no 1357 0.406020335894373 1923 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2950 9072895 21.46 µM 0.235620614986819 0.414312102082251 no 1358 0.406863537672069 1820 17332245 SGTC_1256 0570-0116 285 µM 0.233860248292686 0.414975729346389 no 1359 0.407546737386807 1820 410638 SGTC_3299 9121982 43.1275 µM 0.232958592320758 0.415315731887615 no 1360 0.407896779859435 1856 17594604 YPL160W CDC60 SGTC_1102 cgs 12066b 26.1 µM 0.23233122852253 0.415552339911187 no 1361 0.408140379538152 1906 6438352 A 5-HT1B full agonist. SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.232199367996176 0.415602074536735 no 1362 0.408191584304844 1934 676296 Flavone; oxidizing agent. SGTC_2777 climbazole 1.536 µM 0.231915167903682 0.415709272586425 no 1363 0.408301951695633 1953 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_601 0986-0029 62.9 µM 0.231817484817534 0.41574611933066 no 1364 0.40833988801294 1887 24747981 SGTC_1873 rapamycin 2 nM 0.231653300295544 0.415808052550954 no 1365 0.408403652840685 1871 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.230625312032281 0.416195874848466 no 1366 0.408802950744569 1959 5377381 SGTC_1654 st012436 41.8 µM 0.230200233123458 0.416356265414344 no 1367 0.408968090357696 1999 4323132 SGTC_630 4356-0227 183 µM 0.229884900897361 0.416475255415922 no 1368 0.409090604741342 1927 779312 SGTC_595 3909-8003 73.7 µM 0.228966630507969 0.416821806521856 no 1369 0.409447426089644 1931 699517 SGTC_2824 7998404 51.95 µM 0.228172866399109 0.41712142162376 no 1370 0.409755927280026 1913 837851 SGTC_2591 skatole 100 µM 0.227862341984923 0.417238645630575 no 1371 0.409876629675688 1890 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_3127 9126946 49.47 µM 0.227302743464866 0.417449914515428 no 1372 0.410094169981119 1821 27243249 SGTC_2111 5486399 200 µM 0.22686870054196 0.417613797990667 no 1373 0.410262920419355 1883 689674 SGTC_394 menadione 8.33 µM 0.225604841547736 0.418091080134205 no 1374 0.410754387460005 2015 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1914 st062367 72.6 µM 0.225038669858802 0.418304927680613 no 1375 0.410974595751258 1873 978205 SGTC_1658 st012944 20 µM 0.224983343532403 0.418325826170116 no 1376 0.410996116022738 1987 24207260 SGTC_177 1327-0068 8.361 µM 0.224916332164563 0.418351138775172 no 1377 0.411022181781446 1975 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1688 st021091 57.6 µM 0.223135194664744 0.4190240621244 no 1378 0.411715143705429 2038 3656366 SGTC_1103 duloxetine 36.1 µM 0.221544446580044 0.41962525571865 no 1379 0.412334266449239 1991 60835 A selective serotonin reuptake inhibitor. SGTC_2526 patulin 37.61 µM 0.22066006796355 0.419959571388977 no 1380 0.412678563085966 1924 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_3122 9126309 49.47 µM 0.22061177105666 0.419977830407864 no 1381 0.412697367448287 2063 17591206 SGTC_1201 1889-3372 45.9 µM 0.220196255274119 0.420134926472138 no 1382 0.412859156460635 1906 5392199 SGTC_2989 9073649 71.4286 µM 0.219182781287194 0.420518148811131 no 1383 0.41325383396344 2066 21367202 SGTC_303 1348-1668 34.2 µM 0.218866946918047 0.420637589873202 no 1384 0.41337684738222 1946 5380509 SGTC_1291 0993-0025 5.79 µM 0.218777208954992 0.420671527974355 no 1385 0.413411800714823 2002 4353356 SGTC_3164 9100705 49.47 µM 0.218547644849323 0.420758349764573 no 1386 0.413501220069522 2004 17174235 SGTC_1150 3909-7983 10.9 µM 0.215711136563601 0.421831441947863 no 1387 0.414606459930412 1901 23965914 SGTC_411 enrofloxacin 100 µM 0.215335711031699 0.421973514552261 no 1388 0.414752794624367 2071 71188 A bacterial gyrase inhibitor. SGTC_3157 9099274 49.47 µM 0.21511516369865 0.422056981204035 no 1389 0.414838765862897 2041 17217662 SGTC_1211 1056-0033 32.3 µM 0.215100504430049 0.422062529162498 no 1390 0.414844480315906 2045 6741922 SGTC_3076 9116187 49.47 µM 0.213903840410137 0.42251547164516 no 1391 0.415311022666529 2041 27241210 SGTC_2078 5212016 200 µM 0.213819653456615 0.422547340634626 no 1392 0.41534384906444 2075 1899708 SGTC_1163 k060-0048 49.9 µM 0.21093123485792 0.423641057854834 no 1393 0.416470465262142 1914 6809982 SGTC_2333 9017922 200 µM 0.207923518257863 0.424780573427762 no 1394 0.417644342771267 2027 3163164 SGTC_2993 9054257 71.4286 µM 0.207025466830394 0.42512093514288 no 1395 0.417994984833582 1976 6470217 YGL055W OLE1 SGTC_3196 9111891 49.47 µM 0.20684398100692 0.425189725103682 no 1396 0.418065853473299 2024 18891510 SGTC_268 camptothecin 39.6153 µM 0.206210912696973 0.425429699647792 no 1397 0.418313081967956 2002 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1125 tnp00248 1.32998 µM 0.206208457693931 0.425430630309314 no 1398 0.41831404076894 2065 24207736 SGTC_3268 9137683 49.47 µM 0.206114352056116 0.425466304914767 no 1399 0.418350794074243 1917 1953228 SGTC_1155 4088-0394 48.2 µM 0.206085408056394 0.425477277448853 no 1400 0.418362098403874 1885 2326248 SGTC_2266 7929956 200 µM 0.205636439750728 0.425647486606825 no 1401 0.418537455491437 2018 2967153 SGTC_2137 5261020 140 µM 0.205426706220862 0.425727003801612 no 1402 0.41861937831851 1936 763655 SGTC_778 3456-2434 196 µM 0.205035637510292 0.425875279464914 no 1403 0.418772140878222 2067 5539063 SGTC_642 0335-0876 158 µM 0.205019807221087 0.425881281819342 no 1404 0.418778324897486 1940 6812350 SGTC_2627 acetyl isogambogic acid 100 µM 0.204818565449048 0.425957587950806 no 1405 0.418856940686704 1876 6857789 A caspase activator and apoptosis inducer. SGTC_1019 4262-0212 3.4 µM 0.20448275905736 0.426084923982734 no 1406 0.418988131820203 2070 4677213 SGTC_692 k241-0027 77.8 µM 0.203402810404463 0.426494487061693 no 1407 0.419410101670156 2028 3600480 SGTC_401 neomycin 50 µM 0.202229288467655 0.426939627030291 no 1408 0.419868738623339 1967 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2789 5281112 71.43 µM 0.197565899921007 0.428709456334522 no 1409 0.421692358397201 1877 765948 SGTC_3184 9108758 49.47 µM 0.197136639939291 0.428872439890187 no 1410 0.42186030573267 1978 902885 SGTC_2055 5235184 200 µM 0.196430449093113 0.429140596306105 no 1411 0.422136632771197 1958 2836034 SGTC_1072 oxiconazole 14.9 nM 0.194034557054933 0.430050612947119 no 1412 0.423074411730933 2009 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1448 4255-0083 152 µM 0.194026694178153 0.430053600068843 no 1413 0.423077490069629 2047 5399660 SGTC_2725 haloperidol 53.21 µM 0.19260343903245 0.430594363167075 no 1414 0.423634775700819 2059 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1299 1079-1439 3.74 µM 0.191871578060653 0.430872483101469 no 1415 0.423921400597909 1931 323161 SGTC_190 3970-0790 3.722 µM 0.191374546901522 0.431061383168892 no 1416 0.424116080070607 2065 2832352 SGTC_2606 farnesol 9.78 µM 0.191276144428341 0.431098783568739 no 1417 0.424154625005861 2061 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_204 PMA1.184 62.41 µM 0.190579326969806 0.431363644689362 no 1418 0.424427594003698 2035 2252213 YGL008C PMA1 SGTC_2540 epiandrosterone 100 µM 0.190004934299798 0.431581995219262 no 1419 0.424652631977986 2114 441302 A steroid. SGTC_1911 st060208 74.3 µM 0.18967748187077 0.431706482859915 no 1420 0.42478093366365 2039 688783 SGTC_1885 st057546 99.9 µM 0.189339412031723 0.431835014038949 no 1421 0.424913403800136 2054 702008 SGTC_3266 9136860 49.47 µM 0.188473476431082 0.432164268019971 no 1422 0.425252752827161 1975 4871271 YPR165W RHO1 SGTC_1993 st073995 70.8 µM 0.187921179180946 0.432374292174234 no 1423 0.425469219962349 1991 3098394 SGTC_3067 9117431 49.47 µM 0.187680096683522 0.432465975517956 no 1424 0.425563716775677 1940 17150885 SGTC_161 4065-0411 162.148 µM 0.187047949809242 0.432706397365052 no 1425 0.425811518908275 1980 1906281 YLR208W SEC13 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.18682422052494 0.432791493386762 no 1426 0.42589922801062 1931 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_3318 9139014 38.6185 µM 0.183035454626736 0.434233030670935 no 1427 0.427385099872375 1952 16643984 SGTC_760 0568-0725 82.9 µM 0.182996951767609 0.434247684636569 no 1428 0.427400205184873 2102 3916171 SGTC_2222 6885208 172.143 µM 0.182665303017271 0.434373911972841 no 1429 0.427530320914163 2018 609514 SGTC_707 0865-0008 204 µM 0.181590462129696 0.434783048235847 no 1430 0.427952067259324 2016 723043 SGTC_336 4111-0029 111 µM 0.179470506639972 0.435590209836956 no 1431 0.428784136808241 1964 3131175 SGTC_2563 tomatine 8.54 µM 0.179305797766655 0.435652933130612 no 1432 0.428848797335234 2197 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_395 anisomycin 6.25 µM 0.179277459784205 0.435663724768293 no 1433 0.428859922301141 1975 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3019 9081971 49.47 µM 0.179005182839772 0.435767415399521 no 1434 0.428966816054691 2076 16451803 SGTC_2158 5657123 3.6195 µM 0.178467216597841 0.435972300877489 no 1435 0.429178032613335 2098 2858827 SGTC_172 1112-0046 2.638 µM 0.177451753439974 0.43635908876261 no 1436 0.429576779456246 1986 2802135 YIL048W NEO1 SGTC_2237 6667747 47.222 µM 0.175674452673515 0.437036205335387 no 1437 0.430274853476687 1931 729940 YDL015C TSC13 SGTC_1266 0828-0227 32.9 µM 0.174875109429405 0.437340799626136 no 1438 0.430588884336958 2013 3913820 SGTC_1694 st024011 44.9 µM 0.173655266036099 0.437805699419616 no 1439 0.431068197894644 2095 2787533 SGTC_593 1203-0218 61.7 µM 0.172939630324692 0.438078478445871 no 1440 0.431349440229094 2106 3666956 SGTC_2630 antimycin a 100 µM 0.172297602493253 0.438323225384539 no 1441 0.431601784550749 2023 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2232 chlorophetanol 41.5365 µM 0.172220389116286 0.438352661427955 no 1442 0.43163213458374 2092 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_653 0203-0016 55.2 µM 0.171207319377537 0.438738905376087 no 1443 0.432030376219898 2047 295302 SGTC_2172 5754775 163.918 µM 0.170305110207032 0.439082931648412 no 1444 0.432385096303286 1960 2263357 SGTC_2493 resveratrol 26.09 µM 0.16976995702373 0.439287015572852 no 1445 0.432595527365408 2000 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_373 0844-0104 25.9 µM 0.168887841704606 0.439623450820609 no 1446 0.432942431367968 2124 5375804 SGTC_2112 5488546 200 µM 0.166863766894615 0.440395589289616 no 1447 0.433738621605569 2037 600757 SGTC_1082 camptothecin 424.86 nM 0.16529433584427 0.440994447711472 no 1448 0.434356158420281 1842 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_216 k038-0035 28.382 µM 0.16485869327187 0.441160702782258 no 1449 0.434527602723338 2079 4444231 YPR107C YTH1 SGTC_1765 st044815 90.4 µM 0.164518549528151 0.441290519671138 no 1450 0.434661472645052 1938 645695 SGTC_2254 7938975 95.19 µM 0.162570242711349 0.44203421798765 no 1451 0.43542840906495 2103 2969277 SGTC_3063 1327-0034 4 µM 0.161203366835862 0.442556097418571 no 1452 0.435966614724609 2091 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1730 st033808 45.1 µM 0.160918879182801 0.442664728663585 no 1453 0.436078646324651 1952 1045166 SGTC_2153 5569715 200 µM 0.159411540610163 0.443240375697434 no 1454 0.436672323542496 2098 2054701 SGTC_506 n9-isopropylolomoucine 153 µM 0.157294741979252 0.444048975284118 no 1455 0.437506281985583 2164 6610355 SGTC_1311 1190-0148 100 µM 0.156937129698915 0.444185603315421 no 1456 0.437647198572989 2099 1961333 SGTC_921 1561-0023 372 µM 0.156771629491267 0.444248835961717 no 1457 0.437712416361847 2132 24050882 SGTC_3114 9122766 49.47 µM 0.15668270108035 0.444282813416215 no 1458 0.437747460607991 1984 17176985 SGTC_1964 st076914 61 µM 0.155121876531934 0.44487923421458 no 1459 0.438362617979197 2142 24208661 SGTC_1741 st038134 10.228 µM 0.154127567693864 0.44525924373055 no 1460 0.438754576055131 2086 1272587 SGTC_963 1269-2853 151 µM 0.153406982579053 0.445534671716421 no 1461 0.439038669381928 2002 3668223 SGTC_332 4112-0506 40.9 µM 0.152825598441349 0.445756912325257 no 1462 0.439267905110991 2032 2790355 SGTC_3331 9141060 1.957 µM 0.15237285612255 0.445929989963939 no 1463 0.439446432374684 1987 4906567 YPR165W RHO1 SGTC_923 1900-2434 73.3 µM 0.151886347848914 0.446115987382488 no 1464 0.439638288099669 2096 5910570 SGTC_1733 st037357 54.9 µM 0.151777171648098 0.446157728265124 no 1465 0.439681343950221 1968 1272339 YGL099W LSG1 SGTC_1983 st071813 46.9 µM 0.151498392068604 0.44626431560787 no 1466 0.439791289571012 2026 11838595 SGTC_2888 9058547 12.99 µM 0.14792310784585 0.44763161540982 no 1467 0.441201725699644 2038 16476514 SGTC_1197 1601-0112 267 µM 0.147488805881876 0.44779774870532 no 1468 0.441373107359075 1997 7350313 SGTC_408 cantharidin 100 µM 0.144596143047513 0.448904509695652 no 1469 0.442514871316143 2061 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1484 3473-2379 286 µM 0.144567366506991 0.448915521892689 no 1470 0.442526232129566 2155 671917 SGTC_2281 7943571 200 µM 0.144284272765413 0.449023858208951 no 1471 0.442637998435802 2196 1244024 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.143163159656942 0.449452930958608 no 1472 0.443080662197894 2085 6708784 An antioxidant flavonoid SGTC_734 2023-0417 80 µM 0.142693377312226 0.449632743803288 no 1473 0.443266173666204 2105 3935732 SGTC_3062 9077494 49.47 µM 0.142300805560367 0.449783011627406 no 1474 0.443421205128329 2098 16459633 SGTC_3257 9139206 32.98 µM 0.141593117465587 0.450053917227145 no 1475 0.443700701812456 2130 4910041 SGTC_523 1934-0222 13.7 µM 0.139012001315282 0.451042174290884 no 1476 0.444720332726017 1991 1361595 SGTC_1481 3346-2004 36 µM 0.138672282726827 0.451172268391007 no 1477 0.444854560811811 2172 2770522 SGTC_3256 9138902 49.47 µM 0.137684173600195 0.451550691248256 no 1478 0.445245013950697 2169 17228773 SGTC_640 3381-0960 37.1 µM 0.137155400993114 0.451753216989417 no 1479 0.445453981263477 2146 1745025 SGTC_2990 9074105 71.4286 µM 0.136772643820874 0.451899825045992 no 1480 0.44560525373564 2168 6502001 SGTC_2913 7966556 36.57 µM 0.13671858671963 0.451920531148057 no 1481 0.445626618706461 2153 2976516 SGTC_3216 9129716 49.47 µM 0.135798917613479 0.452272822387782 no 1482 0.445990123377315 2078 8056934 SGTC_488 nitrendipine 139 µM 0.135303987782539 0.452462427282834 no 1483 0.446185766139729 2177 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1021 4476-0760 85.3 µM 0.135191283667285 0.45250560512624 no 1484 0.446230319226544 1965 746768 SGTC_2507 purpurin 79.67 µM 0.134830947394222 0.45264365658587 no 1485 0.446372768384265 2008 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1986 st071812 45 µM 0.132708260848569 0.453457012523029 no 1486 0.447212054722036 2173 11838594 SGTC_1696 st025591 34.7925 µM 0.129806731089353 0.454569115296761 no 1487 0.448359668668781 2157 2787147 SGTC_2987 9018338 71.43 µM 0.129284243873317 0.4547694130982 no 1488 0.448566369183233 2200 5055682 SGTC_392 N-ethylmaleimide 8.33 µM 0.125406663857756 0.456256256678951 no 1489 0.450100806384802 2075 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_559 1550-0661 158 µM 0.124644150498565 0.456548712328866 no 1490 0.450402636943289 2103 5830875 SGTC_2123 5259487 200 µM 0.1244021377615 0.456641539227617 no 1491 0.450498440404603 2165 2173474 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.123326519769625 0.457054134015292 no 1492 0.450924270693876 2211 5024745 SGTC_861 0443-0273 110 µM 0.122871262518327 0.457228779472357 no 1493 0.45110452117339 2127 6149169 SGTC_2785 7756463 72.73 µM 0.121509927199659 0.457751063090699 no 1494 0.451643576099252 2128 2201551 SGTC_3185 9108267 49.47 µM 0.121208107714316 0.457866867673417 no 1495 0.451763101220091 2057 4910486 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.118655520380084 0.458846407455453 no 1496 0.452774138551763 2195 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_629 3448-6466 76.7 µM 0.118362676157819 0.458958800728533 no 1497 0.452890148977382 2160 573744 SGTC_658 3253-0951 102 µM 0.118178918517331 0.459029328373726 no 1498 0.452962946737911 2119 1184878 SGTC_2714 st079313 56.9 µM 0.118115733552161 0.459053579564387 no 1499 0.452987978573825 2131 2939799 SGTC_975 1335-0046 28.5 µM 0.117619960601843 0.45924386878925 no 1500 0.453184394228816 2060 16486740 SGTC_2053 5265679 138 µM 0.115838727332855 0.459927624410685 no 1501 0.453890178564753 2152 764595 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.115084512461401 0.460217178002546 no 1502 0.454189067799793 2115 6708760 SGTC_2769 toremifene 3.73 µM 0.114834598853405 0.46031312797814 no 1503 0.454288112266172 2154 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3094 9117742 49.47 µM 0.114721738180092 0.460356459625121 no 1504 0.454332841555564 2220 17149698 SGTC_1094 duloxetine 25.4 µM 0.114569423087407 0.460414940120281 no 1505 0.454393208459981 2137 60834 A selective serotonin reuptake inhibitor. SGTC_879 0831-1030 162 µM 0.114497863037147 0.460442415481658 no 1506 0.454421570154491 2169 1549252 SGTC_974 1326-0144 138 µM 0.113200155795367 0.460940700641199 no 1507 0.454935936077824 2070 5411856 SGTC_518 1021-0119 62.6 µM 0.112910388269683 0.46105197208921 no 1508 0.455050800176856 2007 1097762 SGTC_1341 1486-1360 280 µM 0.112115998148273 0.461357035477865 no 1509 0.455365716357077 2110 3976547 SGTC_1047 2043-3044 82 µM 0.111493113125418 0.461596253027443 no 1510 0.455612663241147 2142 669592 SGTC_2157 5649910 96.377 µM 0.110895416596199 0.461825810058939 no 1511 0.45584964010577 2105 2858091 SGTC_1794 st048918 76.9 µM 0.110867094718899 0.461836687945542 no 1512 0.45586086965576 2213 672303 SGTC_2754 granisetron 64.02 µM 0.109495891706241 0.462363374561855 no 1513 0.456404590060913 2194 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2273 7815444 169.05 µM 0.109460780792812 0.462376861727278 no 1514 0.456418513597945 2236 2824616 SGTC_526 4469-0568 170 µM 0.108571016678024 0.462718661472508 no 1515 0.456771375083999 2129 2901964 SGTC_2835 9006588 71.43 µM 0.107908794869154 0.462973069526529 no 1516 0.457034020283134 2040 2345538 SGTC_3204 9114183 49.47 µM 0.10753789803319 0.463115564876636 no 1517 0.457181130672821 2120 17027248 SGTC_1671 st016596 74.5 µM 0.107255019893068 0.463224247388909 no 1518 0.457293333778037 2198 2829167 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.107083820119728 0.463290024117998 no 1519 0.457361241514223 2173 65057 A dermal irritant. YDR527W RBA50 SGTC_2830 7992007 71.43 µM 0.106703008683905 0.463436339418993 no 1520 0.457512297826051 2123 1952075 SGTC_1940 st075990 51.1 µM 0.106386534035899 0.463557939015096 no 1521 0.457637838362475 2144 1084979 SGTC_3078 9116413 49.47 µM 0.103619064859618 0.464621432259417 no 1522 0.458735828768138 2204 17177322 SGTC_353 1988-1175 58.3 µM 0.102480573782596 0.465059009622962 no 1523 0.459187615767638 2125 2788357 SGTC_2723 salbutamol 83.58 µM 0.101572442676283 0.465408078793876 no 1524 0.459548026926247 2207 9884233 β2-adrenoceptor agonist SGTC_2317 5986382 200 µM 0.0995426641856731 0.466188384772327 no 1525 0.460353707484507 2187 877883 SGTC_1252 0493-0875 34.8 µM 0.0986601723345712 0.466527681067982 no 1526 0.460704046199629 2182 3960963 SGTC_1344 1488-0097 29.1 µM 0.0978104095327509 0.466854416847231 no 1527 0.46104142070481 2169 747966 SGTC_141 0443-0274 32.331 µM 0.097359880735646 0.467027655295297 no 1528 0.461220301927588 2236 1627241 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.097237363844764 0.467074766875019 no 1529 0.461268948281496 2185 15053 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0969067415911287 0.467201903781138 no 1530 0.461400227496416 2236 1273210 SGTC_1887 st057648 70.8 µM 0.0968302955081369 0.467231300701635 no 1531 0.461430582319079 2219 688672 SGTC_3132 9126706 49.47 µM 0.0962368180072511 0.467459525276024 no 1532 0.461666244983067 2161 850858 SGTC_722 3534-0461 190 µM 0.0943113989027019 0.46820002754719 no 1533 0.462430897630854 2148 658262 SGTC_485 niflumic acid 177 µM 0.0939906895721086 0.468323380797968 no 1534 0.462558276319964 2208 4488 A COX2 inhibitor. SGTC_1954 st077032 68.9 µM 0.093198760223835 0.468627990674102 no 1535 0.462872829650979 2018 698907 SGTC_3319 9138450 16.7555 µM 0.0930033353024753 0.468703162284006 no 1536 0.462950455760568 2109 2029690 SGTC_2796 7949634 45.45 µM 0.0923289282704732 0.468962586380809 no 1537 0.463218352545559 2203 2971588 SGTC_848 0368-0089 85.6 µM 0.0910405975602763 0.469458204988781 no 1538 0.463730166396539 2242 762535 SGTC_2617 dihydrotanshinone i 20.83 µM 0.091010197138165 0.469469900553439 no 1539 0.463742244270118 2201 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2697 mebhydrolin 72.4 µM 0.0910055432101025 0.469471691001843 no 1540 0.463744093245907 2215 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_3189 9110682 49.47 µM 0.0904353357009621 0.469691064571707 no 1541 0.463970638948041 2153 17122418 SGTC_594 1487-1584 10.8 µM 0.090400797098208 0.469704352761276 no 1542 0.463984361647716 2180 5013332 SGTC_1483 3453-0561 55.9 µM 0.0901853454459967 0.469787245190561 no 1543 0.464069964754629 2227 4546991 SGTC_1381 2324-0066 62.1 µM 0.0895205988169305 0.470043006689628 no 1544 0.464334091908162 2166 10885928 SGTC_3116 9124943 49.47 µM 0.0887625040385123 0.470334699000852 no 1545 0.464635328733419 2144 41905195 YPL160W CDC60 SGTC_646 4092-0839 27.3 µM 0.0881572327275048 0.470567600825649 no 1546 0.464875854129972 2222 877796 SGTC_1396 3511-0007 98.6 µM 0.08725583802978 0.47091446635024 no 1547 0.465234078113474 2174 X1396 SGTC_2491 paeonol 100 µM 0.087187238083335 0.470940865189685 no 1548 0.465261341630132 2148 11092 Increases levels of cortical cytochrome oxidase. SGTC_289 k017-0060 526 µM 0.08718328070072 0.470942388085562 no 1549 0.465262914408447 2222 5512909 SGTC_3223 9129970 49.47 µM 0.0870197923612525 0.471005302696311 no 1550 0.465327889877301 2232 17248386 SGTC_2049 5262831 67.185 µM 0.0858693784921682 0.471448032567943 no 1551 0.465785126998758 2183 763417 SGTC_650 1328-0195 38 µM 0.0857119035757903 0.471508638602132 no 1552 0.465847719634621 2255 2780821 SGTC_3165 9101544 49.47 µM 0.0852846474787055 0.471673076348556 no 1553 0.46601754829932 2224 5002184 SGTC_1062 mesoridazine 14.2 µM 0.0848077468901728 0.471856626436623 no 1554 0.466207117302088 2253 4078 A neuroleptic. SGTC_2826 7992541 19.48 µM 0.084768769452605 0.471871628385744 no 1555 0.466222611256303 2276 2985066 SGTC_425 3825-7017 13.1 µM 0.0845000308311898 0.47197506374906 no 1556 0.4663294391653 2191 3397440 SGTC_1959 st077091 55.8 µM 0.0838831281384669 0.472212511839537 no 1557 0.4665746770362 2255 821356 YKL052C ASK1 SGTC_230 MPP+ 141.667 µM 0.0818945504170025 0.472977989443015 no 1558 0.467365284010758 2138 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2836 9010338 19.48 µM 0.0815547068789694 0.473108817937379 no 1559 0.467500409964477 2169 2994051 SGTC_234 nsc-17383 10.7 µM 0.0811758513779471 0.47325466816282 no 1560 0.467651051966612 2252 408974 SGTC_1684 st024538 14.6195 µM 0.0811451280981579 0.473266496041569 no 1561 0.467663268480341 2189 6732859 SGTC_2480 5767542 37.17 µM 0.0802086008210557 0.473627052502843 no 1562 0.468035674868903 2229 2867358 SGTC_3090 9117696 49.47 µM 0.0799060918092347 0.473743520990649 no 1563 0.468155972380986 2244 7923821 SGTC_2204 7233102 200 µM 0.0791740876705703 0.474025357944457 no 1564 0.46844707746037 2218 2172480 SGTC_308 4092-1169 104 µM 0.0784381919423709 0.474308706346436 no 1565 0.468739747162186 2216 2268590 YDL196W YDL196W SGTC_2402 5553605 200 µM 0.0780927239755252 0.474441729406441 no 1566 0.468877147473352 2228 6758546 SGTC_302 1094-0063 18.9 µM 0.0771573607673297 0.474801906946276 no 1567 0.469249180830044 2221 5440289 SGTC_3123 9126162 49.47 µM 0.0770023691385739 0.474861591110588 no 1568 0.469310830132838 2268 25239884 SGTC_821 1114-0266 29.2 µM 0.076783226003215 0.474945979694466 no 1569 0.469397997524843 2198 3123235 SGTC_2624 nerol 100 µM 0.0755680152638945 0.475413958582558 no 1570 0.46988139189979 2247 637566 A natural product oil. SGTC_951 1171-0579 82.7 µM 0.0752323826786183 0.475543217036859 no 1571 0.470014909850705 2267 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3355 9151058 44.0485 µM 0.0745960761617542 0.475788277761339 no 1572 0.470268048097911 2284 17015728 SGTC_2601 securinine 100 µM 0.0742922473275815 0.47590529459452 no 1573 0.470388922860989 2217 442872 A GABA receptor antagonist. SGTC_1399 3562-5772 25 µM 0.0738166506616908 0.476088470369827 no 1574 0.4705781389294 2261 23847490 SGTC_688 0527-0193 473 µM 0.0737267979009223 0.476123077676341 no 1575 0.470613887585327 2206 4007154 SGTC_2190 6049624 200 µM 0.073274378009927 0.476297332525205 no 1576 0.470793890132381 2248 2265554 SGTC_2856 9022925 19.48 µM 0.0730444466425622 0.47638589503848 no 1577 0.470885374322926 2203 4944862 SGTC_704 1310-0270 142 µM 0.0714927916764415 0.476983575237166 no 1578 0.471502780644307 2215 5718033 SGTC_2840 9008771 71.43 µM 0.0711604607266 0.477111592193334 no 1579 0.471635024687498 2273 2992978 SGTC_1115 galangin 695.678 nM 0.0709523372048386 0.477191764502859 no 1580 0.471717844616192 2274 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1466 k213-0079 57.5 µM 0.070951208843124 0.477192199167274 no 1581 0.471718293635747 2271 3657981 SGTC_1845 st056753 3.01 µM 0.0709243658866909 0.477202539545575 no 1582 0.471728975515643 2268 5375839 SGTC_286 k060-0067 22.9 µM 0.0699327161340736 0.477584551147289 no 1583 0.47212360657809 2236 5985051 SGTC_453 enantio-paf c16 10 µM 0.0672774039859353 0.478607553129121 no 1584 0.473180432565908 2275 13871343 A lipid and platelet activating factor SGTC_457 grayanotoxin iii 135 µM 0.0661238795841158 0.479052011388381 no 1585 0.473639599647392 2220 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_2982 9019404 25.97 µM 0.0651620759516498 0.479422618691899 no 1586 0.474022477966386 2205 22333232 SGTC_1525 8-methoxypsoralen 92.5 µM 0.0644806933079688 0.479685183470024 no 1587 0.474293739812151 2310 4114 Related to psoralen; DNA damaging agent. SGTC_173 1273-0061 2.693 µM 0.063980888135274 0.479877784585856 no 1588 0.474492722341184 2201 2847414 YPL266W DIM1 SGTC_2400 5203494 178.7 µM 0.0636782659755236 0.479994403043514 no 1589 0.474613205428081 2287 6777674 SGTC_2490 carminic acid 95.39 µM 0.0636639330327611 0.479999926428043 no 1590 0.474618911866245 2303 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1827 berberine 7.24 µM 0.063546965266607 0.480045001610213 no 1591 0.474665480957046 2251 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_736 0958-0254 92.6 µM 0.0633770508137226 0.480110481001 no 1592 0.474733130651933 2239 6812352 SGTC_2839 9003951 25.97 µM 0.0629177064077171 0.480287499771378 no 1593 0.474916017552282 2335 2990634 SGTC_627 1391-0720 175 µM 0.062790460351725 0.480336537610112 no 1594 0.474966681208264 2233 997839 SGTC_1007 4101-0031 70 µM 0.0615880108308418 0.480799949868674 no 1595 0.475445462394289 2296 1146276 SGTC_1915 st067105 30.6 µM 0.060916987678966 0.481058566934524 no 1596 0.475712660179752 2286 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_313 3474-0040 5.03 µM 0.0607271338204014 0.481131739405177 no 1597 0.475788260945684 2293 1043375 YIL048W NEO1 SGTC_1700 st030840 7.9285 µM 0.0603775745010251 0.481266466371344 no 1598 0.475927459511054 2300 5499307 SGTC_1153 4055-0057 267 µM 0.0595545751915099 0.481583674747463 no 1599 0.476255198929048 2248 882706 SGTC_218 alverine citrate 93.75 µM 0.0590705537451344 0.481770236446018 no 1600 0.476447956190251 2278 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1416 3966-0321 25.3 µM 0.0590453912482227 0.481779935212898 no 1601 0.476457977083246 2267 582530 YLR208W SEC13 SGTC_1981 st071826 47 µM 0.0585155228802945 0.481984172995431 no 1602 0.476668999105177 2201 11838600 SGTC_701 4424-0219 185 µM 0.0579294485882922 0.48221008085859 no 1603 0.476902412961019 2308 2911779 SGTC_2247 cerulenin 830 nM 0.0572625709171642 0.482467142090071 no 1604 0.477168017743998 2290 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_852 0418-0143 439 µM 0.0571003199347773 0.482529686057385 no 1605 0.47723264078488 2313 5369229 SGTC_344 k064-0035 6.43 µM 0.0568642627284612 0.482620681369006 no 1606 0.477326661219575 2233 5088750 SGTC_2298 7976326 193.81 µM 0.0567789896853918 0.482653552637163 no 1607 0.477360625367567 2265 2235818 SGTC_1401 3807-4679 7.6 µM 0.0563681390079228 0.482811930043391 no 1608 0.477524268986662 2301 3291456 SGTC_182 3448-4371 550.524 µM 0.056054752188799 0.482932738268876 no 1609 0.477649094874718 2297 3491403 SGTC_1459 k035-0031 35.7 µM 0.0558498658233151 0.483011721245911 no 1610 0.477730704861812 2297 3877128 YMR208W ERG12 SGTC_1677 st019204 53.9 µM 0.0552665902467891 0.483236575580005 no 1611 0.477963039294991 2164 3945625 SGTC_1259 0671-0132 43 µM 0.0547993391943061 0.483416705991689 no 1612 0.478149163429876 2242 X1259 SGTC_1754 st042065 16.137 µM 0.0544518043364565 0.483550686692807 no 1613 0.478287603075026 2247 1126236 YIL048W NEO1 SGTC_1722 st034304 3.6505 µM 0.0540033761400421 0.483723566264086 no 1614 0.478466237199053 2274 4036148 YLR033W RSC58 SGTC_1840 st055363 71 µM 0.0532462944355603 0.484015445918123 no 1615 0.478767835140618 2180 676033 SGTC_1660 st012960 28.1 µM 0.0531189257009681 0.484064551559522 no 1616 0.47881857610563 2246 24207266 SGTC_2544 sphondin 68.51 µM 0.0529355227718306 0.484135261004448 no 1617 0.478891640491684 2293 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2477 5967686 25.23 µM 0.0517880455642388 0.484577672354021 no 1618 0.479348790513775 2294 776118 SGTC_831 k061-1017 217 µM 0.0508209467919615 0.484950553326106 no 1619 0.479734099658542 2287 1240153 SGTC_1505 k297-0037 20.6 µM 0.0505632503570903 0.485049914694791 no 1620 0.479836773656738 2271 4089396 SGTC_1313 1220-0047 237 µM 0.0478014684603154 0.486114846484598 no 1621 0.480937233116951 2262 3528706 SGTC_1168 k815-0004 80.5 µM 0.0471633902235553 0.486360901199279 no 1622 0.481191502702168 2307 642433 SGTC_1545 lovastatin 49.4 µM 0.0470859812196379 0.486390751891278 no 1623 0.481222350155658 2293 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2750 bromebric acid 70.15 µM 0.0446942167924315 0.487313108010983 no 1624 0.482175521712342 2283 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_633 0437-0093 97.7 µM 0.0439679057279611 0.487593215081698 no 1625 0.48246499331751 2316 2831118 SGTC_2386 9075165 157.42 µM 0.0437983016268473 0.487658625006145 no 1626 0.482532590446147 2274 16452277 SGTC_2072 5231554 129 µM 0.0422915857206102 0.488239723048241 no 1627 0.483133126454423 2333 789545 SGTC_1337 1486-1011 40.3 µM 0.040839424294038 0.488799804599965 no 1628 0.483711954760317 2343 X1337 SGTC_1826 st055655 41.6 µM 0.0389493061825623 0.489528833803026 no 1629 0.48446540286017 2228 676168 SGTC_2873 9040596 71.43 µM 0.0377751909074151 0.489981714449621 no 1630 0.484933462519047 2201 6463863 SGTC_943 3253-1379 105 µM 0.0369481226783781 0.490300739631065 no 1631 0.4852631847861 2322 668464 SGTC_2762 leflunomide 42.06 µM 0.0356858449160868 0.490787650159449 no 1632 0.485766428742156 2322 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_812 4251-0442 148 µM 0.0348885566884458 0.491095202927238 no 1633 0.486084302749577 2339 5723007 SGTC_855 0428-0020 25 µM 0.0345935075995166 0.491209019033619 no 1634 0.486201939294008 2264 6812414 SGTC_2688 kanamycin b 96.69 µM 0.0343602818348215 0.4912989871068 no 1635 0.486294927630203 2320 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1573 oleylamine 1.06 µM 0.0340741417050012 0.491409367780622 no 1636 0.486409014218874 2314 5356789 An amine of the fatty acid oleic acid. SGTC_200 k038-0079 37.545 µM 0.0328891002558641 0.491866513204042 no 1637 0.48688151241538 2293 3436683 SGTC_3295 9122362 53.5725 µM 0.0325006657461883 0.492016359311232 no 1638 0.487036392561375 2289 4730473 SGTC_2570 licareol 100 µM 0.0324196663099307 0.49204760654937 no 1639 0.487068689641586 2286 443158 SGTC_113 0099-0221 2.5 µM 0.0320034853139183 0.492208157897437 no 1640 0.48723463572203 2346 89219 SGTC_1189 1431-2119 7.28 µM 0.0319305625064 0.492236289670776 no 1641 0.487263712852528 2353 3107275 SGTC_1279 0874-0590 65.2 µM 0.0319021322093111 0.492247257370243 no 1642 0.487275049124745 2315 3523074 SGTC_2481 5478948 45.16 µM 0.0318801816686432 0.492255725345321 no 1643 0.487283801671492 2314 77792 SGTC_2698 st077697 67.5 µM 0.0317367046978218 0.492311075293849 no 1644 0.487341011752122 2308 3154499 SGTC_169 k015-0017 16.025 µM 0.0309377519209318 0.492619294647989 no 1645 0.487659591321935 2323 1840002 SGTC_1507 4075-3230 155 µM 0.0296137880731585 0.493130061959949 no 1646 0.488187534422342 2344 659771 SGTC_1136 pergolide 1.05886 µM 0.0284593063671555 0.493575454580387 no 1647 0.488647911843394 2313 47811 A dopamine receptor agonist. SGTC_1327 1436-0082 2.18 µM 0.0284575290235323 0.493576140275988 no 1648 0.488648620613844 2242 15992205 SGTC_2719 novobiocin 32.65 µM 0.0279984122923502 0.493753267218781 no 1649 0.488831708729429 2349 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_799 1310-0557 151 µM 0.0277170715710499 0.493861808900893 no 1650 0.488943903894796 2277 5354492 SGTC_1967 st070177 51.4 µM 0.0275491617692405 0.493926588977221 no 1651 0.489010864643822 2335 5729214 SGTC_709 3807-1509 243 µM 0.0273433924734455 0.494005975571611 no 1652 0.489092923802452 2351 1886677 YPL242C IQG1 SGTC_1991 st073000 8.92 µM 0.0272261124181617 0.494051222779358 no 1653 0.489139694362533 2337 4301969 YIL048W NEO1 SGTC_346 4513-0042 7.16 µM 0.0265605642461054 0.494307995888127 no 1654 0.489405113663283 2359 2827372 SGTC_3247 9135149 49.47 µM 0.0265224485111487 0.494322701275898 no 1655 0.48942031428651 2359 8934436 YOR116C RPO31 SGTC_2911 7942208 15.64 µM 0.0258790533677029 0.494570929962894 no 1656 0.489676903721021 2326 1243384 SGTC_402 epigallocatechin gallate 10 µM 0.0258391822826325 0.494586312721589 no 1657 0.489692804665298 2304 65064 An antioxidant. SGTC_617 3770-0098 35 µM 0.0245193547995928 0.495095522925142 no 1658 0.490219172728968 2329 5962639 SGTC_37 0566-0070 1.56 µM 0.0237681289157785 0.49538536130968 no 1659 0.490518781152472 2362 1626686 SGTC_478 N-arachidonylglycine 10 µM 0.0236430413066912 0.495433622920668 no 1660 0.490568669868888 2366 5283389 SGTC_1449 4112-4002 201 µM 0.0230723020608699 0.49565382778684 no 1661 0.490796299778315 2310 2059539 SGTC_2396 5342950 42.78 µM 0.0221601889441522 0.496005745587383 no 1662 0.491160087202932 2336 1886677 SGTC_3154 9100113 49.47 µM 0.0211471214418766 0.496396617939845 no 1663 0.491564147905961 2347 25237525 SGTC_520 3584-0023 682 µM 0.0210459196632823 0.496435664870064 no 1664 0.49160451259086 2254 1340790 SGTC_1123 mangostin 811.285 nM 0.0195117690343888 0.497027593932659 no 1665 0.492216424249615 2308 5281650 An antioxidant. SGTC_165 k038-0023 64.381 µM 0.0188591592109364 0.497279395726809 no 1666 0.492476729984836 2376 46368543 SGTC_2256 7954252 200 µM 0.0186528300836469 0.497359005614439 no 1667 0.492559028920109 2279 2972920 SGTC_1973 st070275 50.2 µM 0.0182115188059292 0.497529281201309 no 1668 0.49273505674135 2383 17118334 SGTC_372 0155-0182 15.9 µM 0.0170176694984782 0.497989918303189 no 1669 0.493211259795818 2340 771486 SGTC_777 1315-0167 517 µM 0.0168600486757893 0.498050735236656 no 1670 0.493274132385691 2286 4221767 SGTC_2966 9084041 48.03 µM 0.0161838565311436 0.49831163992057 no 1671 0.49354385720016 2383 17741380 SGTC_1574 spiramycin 23.7 µM 0.01574125564505 0.498482415216195 no 1672 0.493720406911377 2370 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1188 1403-0014 4.57 µM 0.0156869382149295 0.498503373339498 no 1673 0.493742073755519 2371 9614867 SGTC_3003 9075612 71.4286 µM 0.0148184209994443 0.4988384871178 no 1674 0.494088521681245 2352 6501993 SGTC_2748 diazoxide 86.69 µM 0.0145665154671342 0.498935683990198 no 1675 0.494189006602129 2376 3019 A potassium channel activatior. SGTC_1314 1222-0010 41.1 µM 0.0128374197962484 0.499602850934097 no 1676 0.494878751135479 2361 3526027 SGTC_2874 9043904 71.43 µM 0.0124219109883589 0.499763174133184 no 1677 0.495044501945778 2330 4463428 SGTC_2709 st078560 56 µM 0.0119315335435369 0.499952385285476 no 1678 0.495240119737 2382 17250903 SGTC_986 1493-0483 84 µM 0.0116847280025932 0.499952385285476 no 1679 0.495338574037993 2381 40079 SGTC_1999 st074831 12.5 µM 0.0116678718471528 0.499945881371329 no 1680 0.495345298212694 2372 17112523 SGTC_1669 st015249 58.4 µM 0.0115647014576052 0.499906073281512 no 1681 0.495386454466284 2386 722793 SGTC_1807 st050092 58.9 µM 0.0114304074113894 0.499854256192069 no 1682 0.495440026498224 2375 5008496 SGTC_2834 9001755 58.44 µM 0.00950960793055427 0.499113120243026 no 1683 0.496206272506015 2354 2989575 SGTC_2131 toluylene red 5.2905 µM 0.00895651868583424 0.498899712517534 no 1684 0.496426913782781 2381 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3036 9090181 49.47 µM 0.0082513240920211 0.498627615891757 no 1685 0.496708235303383 2388 25236586 SGTC_2165 5727197 32.143 µM 0.0064097083560034 0.497917038863822 no 1686 0.497442913841135 2377 1361712 SGTC_393 acivicin 6.25 µM 0.00552868251445787 0.497577102218312 no 1687 0.497794386026327 2394 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_3245 9134821 49.47 µM 0.00551338179513273 0.497571198575204 no 1688 0.497800490037155 2393 17014901 SGTC_3328 9140624 29.0385 µM 0.00464126819928971 0.497234702411287 no 1689 0.498148408528259 2394 4904392 SGTC_284 0988-0104 32.6 µM 0.00420759270517587 0.497067373848668 no 1690 0.498321418324087 2383 4666532 SGTC_2294 7971431 200 µM 0.00350280696723781 0.496795441717083 no 1691 0.498602585058318 2396 5741572 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.00339565559586223 0.496754098923727 no 1692 0.498645332016457 2403 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1742 st038235 28.8875 µM 0.00139201242145383 0.495981029340136 no 1693 0.499444667569583 2397 564103 YBR002C RER2 SGTC_2403 6032726 181.2 µM 0.00120247252537914 0.495907899525559 no 1694 0.499520282984212 2401 2881040 SGTC_3255 9139072 49.47 µM 0.000351733066931017 0.495579662080959 no 1695 0.499859678811079 2401 17646060 SGTC_549 1661-1316 519 µM 0.000208148807888713 0.495524263822575 no 1696 0.499916960640518 2404 2857282 SGTC_365 0121-0052 13.6 µM -0.000194959676903701 0.495368735344627 no 1697 0.499922222342402 2407 3101739 SGTC_314 1671-0008 2.74 µM -0.000961701140160614 0.495072910904886 no 1698 0.499616336813219 2410 3913060 SGTC_2595 hexamethylquercetagetin 100 µM -0.00107653884824682 0.495028604412471 no 1699 0.499570523219896 2410 386331 SGTC_1010 4112-3296 15.2 µM -0.00108944326495845 0.495023625655827 no 1700 0.499565375105485 2408 704384 SGTC_351 caspofungin 25 nM -0.00154757251978984 0.494846871636891 no 1701 0.499382608136309 2408 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_924 2046-0044 21.3 µM -0.00208830537140292 0.494638249056909 no 1702 0.499166887298495 2407 3623589 SGTC_501 nsc-95397 161 µM -0.00210555055710342 0.494631595637871 no 1703 0.499160007479911 2412 262093 SGTC_3344 9148862 3.898 µM -0.00311195643505683 0.49424331368594 no 1704 0.498758511007109 2413 4905352 SGTC_1455 4262-0120 131 µM -0.00396959571255072 0.493912431739897 no 1705 0.498416364593237 2410 1529587 SGTC_1764 st044502 93.5 µM -0.00434642549006305 0.493767050051974 no 1706 0.498266032562917 2415 8407 SGTC_1351 1496-0003 46.5 µM -0.00549636428066609 0.493323406547553 no 1707 0.497807278940318 2420 3891978 SGTC_2925 9010536 32.5 µM -0.00565752342703782 0.49326123239984 no 1708 0.497742986742852 2422 2994177 SGTC_421 streptovitacin 30 mM -0.00569050069709709 0.493248510004231 no 1709 0.497729830927307 2477 91467 include heat shock SGTC_167 3672-0051 66.205 µM -0.00596617182145233 0.493142158320321 no 1710 0.497619855928578 2414 3237971 SGTC_928 2764-0428 58.7 µM -0.00613008114151016 0.49307892366465 no 1711 0.497554466766701 2449 662578 SGTC_1676 st018489 23.4 µM -0.0063905319004566 0.492978444599074 no 1712 0.497450563983358 2429 3696235 SGTC_2882 9058044 58.44 µM -0.00712490865001168 0.492695132468903 no 1713 0.497157596744312 2427 18076804 SGTC_1683 st010134 710 nM -0.00798489098789677 0.492363368179335 no 1714 0.496814523230763 2421 3818134 SGTC_2339 9000433 200 µM -0.00864731138988098 0.492107822992678 no 1715 0.496550264867729 2427 2988954 SGTC_68 0986-0284 82.829 µM -0.00866210617035741 0.49210211557381 no 1716 0.496544362825315 2478 423278 YIL048W NEO1 SGTC_3316 9136639 10.545 µM -0.00877361741506859 0.492059097658657 no 1717 0.496499877965564 2453 4903665 SGTC_297 0986-0032 24 µM -0.00957910840907309 0.491748364566097 no 1718 0.49617854708948 2424 2847425 SGTC_259 usnic acid 108.925 µM -0.00963819639839329 0.491725570472994 no 1719 0.496154975480443 2434 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_643 k048-0106 28.4 µM -0.0101266989842073 0.491537124191778 no 1720 0.495960100663054 2441 6763920 SGTC_3092 9117248 49.47 µM -0.0121015199337232 0.490775330789551 no 1721 0.495172309874887 2432 17141857 SGTC_1186 1319-0216 26 µM -0.0124857572159181 0.490627113871037 no 1722 0.495019032961336 2431 4565136 SGTC_2270 7924575 90.91 µM -0.0131344686024707 0.490376880813048 no 1723 0.494760255799406 2434 1262135 SGTC_2890 9046729 58.44 µM -0.013805339116566 0.490118104107898 no 1724 0.494492641470524 2444 903329 SGTC_1962 st076595 64.5 µM -0.01520032149234 0.489580027210292 no 1725 0.493936182589183 2429 279619 SGTC_1038 k292-0204 154 µM -0.0157632304628986 0.489362905543704 no 1726 0.493711641315018 2424 4454212 SGTC_3050 9093513 49.47 µM -0.015825524377253 0.489338878123953 no 1727 0.49368679273836 2437 25236664 SGTC_83 0170-0301 39.027 µM -0.0173547482089548 0.488749052711497 no 1728 0.493076804705204 2432 3089716 SGTC_1060 3448-7350 82 µM -0.0177043810821835 0.488614201857274 no 1729 0.492937342799132 2441 570178 SGTC_131 0141-0277 33.849 µM -0.0177380702610132 0.48860120825473 no 1730 0.492923904871507 2454 1547771 SGTC_2489 cantharidin 73.42 µM -0.0193327258118208 0.487986178542531 no 1731 0.492287838690141 2443 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1193 1488-0126 41.5 µM -0.0193939409415429 0.487962569537759 no 1732 0.492263421964515 2449 1384710 SGTC_900 1112-0045 141 µM -0.0204356080907543 0.487560833482584 no 1733 0.491847939313385 2435 56211 YIL048W NEO1 SGTC_2828 7998861 71.43 µM -0.0211659875938322 0.487279158127337 no 1734 0.491556623084521 2445 2988188 SGTC_2565 isoliquiritigenin 100 µM -0.0211662951286869 0.487279039525952 no 1735 0.491556500423344 2506 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1862 st057513 3.81 µM -0.0214623026334711 0.487164884208213 no 1736 0.491438437335838 2447 5393163 SGTC_3206 9114350 49.47 µM -0.0214635627889795 0.487164398231382 no 1737 0.491437934722305 2434 17087243 SGTC_2313 7726885 200 µM -0.0216445553204934 0.487094598967469 no 1738 0.491365745919739 2462 726423 SGTC_1064 honokiol 6.76 µM -0.0217577586692169 0.48705094261325 no 1739 0.49132059495063 2460 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_962 1254-0300 21.5 µM -0.0235654030978694 0.486353854173663 no 1740 0.490599634405662 2445 7340576 SGTC_1743 st037606 46.3785 µM -0.0241303298350653 0.486136007890125 no 1741 0.490374325325944 2467 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2290 7904846 200 µM -0.0251328835975343 0.48574941469295 no 1742 0.489974485571457 2473 2962154 SGTC_1734 st037168 69.4 µM -0.0256364470874092 0.485555241388968 no 1743 0.489773657521939 2509 708907 SGTC_622 1348-1566 26.3 µM -0.0260943716668912 0.485378669350455 no 1744 0.489591033147387 2476 7340407 SGTC_2923 7992654 58.14 µM -0.0261780281654454 0.485346412385456 no 1745 0.489557670430091 2457 2985126 SGTC_2461 5755302 26.15 µM -0.026551169467986 0.485202534644802 no 1746 0.48940886031616 2450 2788904 SGTC_1212 0520-0165 585 µM -0.0269416099613536 0.485051988656013 no 1747 0.489253152800519 2482 5403258 SGTC_274 sirtinol 40.1 µM -0.0274272747859922 0.484864729059234 no 1748 0.489059472147404 2477 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1176 0848-0131 83.3 µM -0.0281744351133393 0.48457665019867 no 1749 0.488761513476037 2476 6769040 SGTC_3091 9116372 49.47 µM -0.0296372896218713 0.484012648170519 no 1750 0.488178162774428 2560 17169793 SGTC_3356 9151811 4.48 µM -0.0299880571233838 0.483877414838513 no 1751 0.488038288961621 2454 1859254 YPR165W RHO1 SGTC_3137 9097352 49.47 µM -0.0302259978147605 0.483785681304489 no 1752 0.48794340737148 2485 44120435 SGTC_823 0417-1665 178 µM -0.0304957620743814 0.48368167983388 no 1753 0.487835836592788 2494 3429856 SGTC_1500 4488-1866 171 µM -0.0306072469413034 0.48363869970459 no 1754 0.487791381317766 2461 2900003 SGTC_1319 1306-0155 43.7 µM -0.0318656680651212 0.4831535610399 no 1755 0.487289588821297 2470 3122360 SGTC_3145 9085516 49.47 µM -0.0321285157019073 0.483052232782864 no 1756 0.487184781451336 2517 25236195 SGTC_2921 7974240 10.71 µM -0.0324288652467648 0.48293644881035 no 1757 0.487065021725356 2484 2979074 YDR527W RBA50 SGTC_1405 3909-7894 12 µM -0.034014653554309 0.482325155607425 no 1758 0.486432732808209 2489 7104060 SGTC_1874 staurosporine 7.6 µM -0.0343378744995436 0.482200564729565 no 1759 0.486303861591673 2488 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_3202 9113761 49.47 µM -0.0344427917793328 0.48216012299587 no 1760 0.486262030396928 2530 4798415 SGTC_2650 prasterone 100 µM -0.0352190672566952 0.481860903221341 no 1761 0.485952529094996 2459 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1651 st011928 86.1 µM -0.0357723222401091 0.481647654184336 no 1762 0.485731951294736 2518 720198 SGTC_1237 0330-0133 46.1 µM -0.0364320147643359 0.481393386261605 no 1763 0.485468943513159 2482 X1237 YHR072W ERG7 SGTC_1275 0867-0008 21.1 µM -0.0366856836589229 0.48129561565628 no 1764 0.485367811872464 2479 3422836 SGTC_954 1189-0853 2.85 µM -0.0373515783295483 0.481038967857914 no 1765 0.48510234029963 2455 2828194 SGTC_1829 berberine 14.4 µM -0.0377736179404121 0.480876310253393 no 1766 0.484934089594542 2560 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_195 4234-0266 16.654 µM -0.0384022920540369 0.480634019891003 no 1767 0.484683466768397 2486 2303354 SGTC_2345 9052315 157.45 µM -0.038955366668875 0.480420871410873 no 1768 0.484462986909478 2514 6469265 SGTC_1569 carminic acid 40.6 µM -0.0395819072665172 0.480179416767143 no 1769 0.484213226021901 2477 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_153 4077-0274 519.67 µM -0.0404338143223826 0.479851122646592 no 1770 0.483873636176053 2485 3121976 SGTC_495 decylubiquinone 155 µM -0.0405114679513354 0.479821198427183 no 1771 0.483842682222454 2525 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2284 7945075 39.21 µM -0.0408666388470451 0.479684332974959 no 1772 0.483701106780736 2519 1245402 SGTC_2505 galangin 7.89 µM -0.0411427096507495 0.47957795047422 no 1773 0.483591063016876 2481 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1749 st037932 54.2 µM -0.0415396135580194 0.47942500809358 no 1774 0.483432856520529 2545 594497 SGTC_1861 st057647 17.4 µM -0.0430866822595053 0.478828891988888 no 1775 0.482816217729229 2507 688668 SGTC_248 streptozotocin 5.23457 mM -0.0450308948459096 0.478079815818534 no 1776 0.482041341699153 2562 5300 DNA alkylating agent. SGTC_1242 0402-0103 60.1 µM -0.0464552759729135 0.477531071965767 no 1777 0.481473690088487 2488 432868 SGTC_2297 7971671 152.32 µM -0.0466938099503699 0.477439180715513 no 1778 0.481378631955206 2533 909016 SGTC_1849 st056239 19.2 µM -0.0472749323141558 0.477215318014 no 1779 0.481147053426983 2497 5393181 SGTC_1219 1469-0211 33.1 µM -0.0477556969189565 0.477030121033855 no 1780 0.480955472489795 2494 6822282 SGTC_426 0988-0037 14.6 µM -0.0491328477580176 0.476499651637302 no 1781 0.480406713142122 2483 5383008 SGTC_1288 0973-0013 65.5 µM -0.0494197390668098 0.476389148212383 no 1782 0.480292398940031 2551 4315430 SGTC_3335 9143315 29.6265 µM -0.0496627404663243 0.476295551513193 no 1783 0.480195574300765 2517 4899691 SGTC_2124 5246320 200 µM -0.0500816178005301 0.476134215861815 no 1784 0.480028674112116 2560 579342 SGTC_1784 st039334 36.3 µM -0.0513600297455402 0.475641844403756 no 1785 0.479519317178011 2600 3496984 SGTC_1616 st002734 56.1 µM -0.0515689425760851 0.475561386597565 no 1786 0.479436083316484 2520 4026101 SGTC_2271 7849410 118.62 µM -0.0516550564683996 0.475528222170625 no 1787 0.479401774570158 2478 972430 SGTC_2676 harmalol 100 µM -0.0530945271192059 0.47497387442437 no 1788 0.478828296015159 2492 5459187 A monoamine oxidase inhibitor SGTC_2023 5144124 124 µM -0.0562120312111874 0.473773474636505 no 1789 0.477586448398917 2526 2830192 SGTC_717 1532-0246 73.2 µM -0.0569213163235201 0.473500396159677 no 1790 0.477303936934899 2527 9561992 SGTC_2349 9023730 187.07 µM -0.0606091913782491 0.472080748559172 no 1791 0.47583522666129 2548 4126287 SGTC_2243 6634756 200 µM -0.062708738229042 0.47127268520169 no 1792 0.474999219495186 2665 885676 SGTC_2760 etidronate 98.04 µM -0.0627268255148206 0.471265724364296 no 1793 0.474992017889919 2547 3305 A chelator and antioxidant. SGTC_2513 baicalein 25.65 µM -0.0651628784644129 0.470328297802471 no 1794 0.474022158489109 2561 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1349 flufenamic acid 69 µM -0.0652430251975538 0.470297459006307 no 1795 0.473990252463804 2524 3371 A non-steroidal anti-inflammatory. SGTC_2724 maprotiline 69.64 µM -0.0657569718420119 0.470099707267505 no 1796 0.473785656774082 2508 4011 A tricyclic antidepressant. SGTC_2301 7769476 200 µM -0.0666636462535183 0.469750863302024 no 1797 0.473424737995526 2566 977820 SGTC_1770 st043884 66.3 µM -0.0678579221550958 0.469291399824479 no 1798 0.472949367380627 2530 670149 SGTC_442 cape 100 µM -0.0682167340743326 0.469153365166752 no 1799 0.472806553068223 2522 5281787 SGTC_2658 polymyxin b sulfate 77.05 µM -0.0704618055901389 0.468289772784777 no 1800 0.471913049841536 2555 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_217 ketoconazole 989 nM -0.0713503208811838 0.467948036219257 no 1801 0.471559473487461 2519 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_19 0279-0214 38.434 µM -0.0716388736096139 0.467837059496798 no 1802 0.471444651434845 2542 3566274 YBR002C RER2 SGTC_3285 9112818 20.8695 µM -0.0721174886576831 0.467652990754568 no 1803 0.471254204264008 2510 17017947 YPR165W RHO1 SGTC_1352 1496-0991 99 µM -0.0724918822365337 0.467509008970159 no 1804 0.471105232755265 2537 3000039 SGTC_553 k007-0256 45.7 µM -0.0725198992467138 0.467498234546047 no 1805 0.471094084926529 2582 6287000 SGTC_2367 9070478 135.38 µM -0.0726466839766722 0.467449477590933 no 1806 0.471043638197562 2538 572802 SGTC_3259 9138485 49.47 µM -0.073241945876335 0.467220567307868 no 1807 0.470806794009221 2542 17646153 SGTC_967 1306-0166 352 µM -0.0733957316834427 0.467161430135558 no 1808 0.470745607029876 2552 4437607 SGTC_2353 9059630 146.67 µM -0.0738295050583652 0.466994629765579 no 1809 0.470573024721905 2605 4779114 SGTC_1273 0849-0096 14.1 µM -0.0738660638695217 0.466980571944425 no 1810 0.470558479581464 2570 5286025 SGTC_2046 4110841 106 µM -0.0741443907093127 0.466873549330806 no 1811 0.470447746882181 2551 44119630 YMR134W ERG29 SGTC_918 glabranin 770.725 nM -0.0743923629802158 0.466778200714319 no 1812 0.470349092712659 2572 124049 Also referred to as licorice root. SGTC_1300 1094-0077 113 µM -0.074667469328557 0.466672420917393 no 1813 0.470239645555078 2551 5532636 SGTC_1713 st033146 12.748 µM -0.0752257952799465 0.466457748980033 no 1814 0.470017530416616 2563 674619 SGTC_3311 9131146 2.8755 µM -0.0763637949274129 0.466020227345391 no 1815 0.469564836465497 2592 4900406 YPR165W RHO1 SGTC_1467 k284-1082 293 µM -0.0765849295424574 0.465935213457661 no 1816 0.469476874110866 2550 3334705 SGTC_3035 9091303 49.47 µM -0.0772049805989011 0.46569684681855 no 1817 0.469230239765274 2550 25237002 SGTC_1003 4049-0218 100 µM -0.0774164858985419 0.46561554050643 no 1818 0.469146113145194 2620 295161 SGTC_2837 9008476 45.46 µM -0.0790285359265845 0.464995887869819 no 1819 0.468504962826531 2673 2992805 SGTC_2306 7482397 179.52 µM -0.0808301075408907 0.464303485911831 no 1820 0.467788532023537 2601 891448 SGTC_2159 5658611 73.75 µM -0.0812154661964741 0.464155394138978 no 1821 0.467635299950681 2536 793844 SGTC_1740 st038286 13.222 µM -0.0813110213531298 0.464118673446277 no 1822 0.467597304621101 2644 716786 SGTC_207 4185-0010 4.486 µM -0.0819198150682975 0.46388472856376 no 1823 0.467355238625907 2546 3761753 SGTC_1342 1486-1464 234 µM -0.0820720243097605 0.463826240136177 no 1824 0.467294719710761 2547 3253938 SGTC_1159 4092-0538 61.2 µM -0.083158681472084 0.46340870044257 no 1825 0.466862683153053 2547 717301 SGTC_2424 5537928 59.2 µM -0.0838887765605667 0.463128189604119 no 1826 0.466572431556277 2574 5382802 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0845187403502879 0.462886165078263 no 1827 0.466322001752952 2616 23847180 SGTC_3197 9113331 49.47 µM -0.0852235264804068 0.462615410993986 no 1828 0.466041843596869 2650 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2035 5154463 94.595 µM -0.0855716038659624 0.462481698265833 no 1829 0.465903486234956 2601 2769623 SGTC_3236 9132701 49.47 µM -0.0857716259999346 0.462404862369532 no 1830 0.465823981253253 2578 24282524 SGTC_652 0437-0092 114 µM -0.0871341847022366 0.461881490673189 no 1831 0.465282426623425 2565 3091274 SGTC_2141 5621638 7.665 µM -0.0881720343699434 0.46148288702334 no 1832 0.464869972034239 2666 2856238 SGTC_1936 st074407 74.3 µM -0.0884394320457655 0.461380194693111 no 1833 0.464763710911657 2560 809813 SGTC_1318 1280-3875 124 µM -0.0891992095482512 0.461088421183217 no 1834 0.464461796782142 2612 373245 SGTC_569 4130-2812 160 µM -0.0892924016729976 0.461052634522038 no 1835 0.464424766268003 2561 743552 SGTC_2895 9054447 58.44 µM -0.0897115925524949 0.460891665146532 no 1836 0.46425820178302 2567 2697450 SGTC_2495 cafestol 54.53 µM -0.09174699837165 0.460110160506369 no 1837 0.463449527765572 2769 16667697 An anti-infammatory. SGTC_572 0960-0087 17.7 µM -0.092414416379469 0.459853935291585 no 1838 0.463184392914624 2561 6796365 SGTC_196 k015-0023 18.111 µM -0.0928500636126312 0.459686697058434 no 1839 0.463011338875498 2570 5211998 SGTC_1348 1493-0373 93.8 µM -0.0938096959865621 0.459318334237729 no 1840 0.462630164685277 2633 3010129 SGTC_355 1311-2252 105 µM -0.0943740621786395 0.459101713897303 no 1841 0.462406009606042 2610 5338538 SGTC_2948 9070189 9.45 µM -0.0961273183366691 0.45842884036789 no 1842 0.461709727437573 2637 6473636 YDL196W YDL196W SGTC_5 0352-0601 109.883 µM -0.0966062391158592 0.458245058355068 no 1843 0.461519550787942 2556 762456 SGTC_3180 9109287 49.47 µM -0.0969572858324415 0.458110352656516 no 1844 0.461380157769073 2671 18891271 SGTC_649 1123-0311 367 µM -0.098358075530082 0.457572881498058 no 1845 0.460823982041647 2640 693629 YIL048W NEO1 SGTC_3170 9103054 49.47 µM -0.0985566794908279 0.45749668509512 no 1846 0.460745133625025 2648 16432970 SGTC_2655 perillic acid 100 µM -0.0987553231646732 0.457420475018608 no 1847 0.460666270985581 2579 5702197 An apoptosis inducer. SGTC_2036 5160441 105 µM -0.0992082276228988 0.457246723099253 no 1848 0.460486471195118 2606 134534 YIL048W NEO1 SGTC_922 1866-0035 480 µM -0.0999339022509816 0.456968342891308 no 1849 0.46019840047952 2596 3156169 SGTC_2193 5925765 200 µM -0.10002130733268 0.456934814348496 no 1850 0.460163704731995 2667 877370 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.103238328969293 0.4557009818142 no 1851 0.458886910150346 2633 688798 SGTC_529 4076-0302 30.3 µM -0.103464533573055 0.45561424091781 no 1852 0.458797148249225 2596 5816522 SGTC_2931 9014674 55.67 µM -0.103850830004548 0.455466115763996 no 1853 0.458643864000107 2604 2996810 SGTC_2006 4011487 200 µM -0.104021010518614 0.455400862102781 no 1854 0.458576337517964 2669 45595294 SGTC_1791 st048313 56.1 µM -0.104264753590073 0.455307403864263 no 1855 0.458479623990947 2606 1204976 SGTC_360 0957-0399 1.01 µM -0.105500433908834 0.454833645968386 no 1856 0.45798936285119 2699 6752301 YPR165W RHO1 SGTC_321 4534-3890 65.3 µM -0.106132253186619 0.454591432225462 no 1857 0.457738710656053 2676 699746 SGTC_2389 9091542 195.52 µM -0.106691307971515 0.454377127497106 no 1858 0.457516939240013 2657 3626624 YOL127W RPL25 SGTC_124 0136-0217 7.121 µM -0.106857085777898 0.454313581771187 no 1859 0.457451179389529 2617 3976905 SGTC_3173 9105693 49.47 µM -0.107208737201475 0.454178791093172 no 1860 0.457311692048665 2709 17096658 SGTC_910 3454-3003 490 µM -0.108599155065615 0.453645885130636 no 1861 0.45676021547571 2595 820824 SGTC_1831 st055328 12 µM -0.109740784368332 0.453208394796821 no 1862 0.456307477242902 2616 1103068 SGTC_91 0417-1751 58.384 µM -0.109835658076973 0.453172040245393 no 1863 0.456269855529639 2576 6795624 SGTC_820 1582-0060 59.9 µM -0.111510994730118 0.452530134779456 no 1864 0.455605573721222 2635 3848840 SGTC_2665 lovastatin 100 µM -0.113822608782599 0.451644643542271 no 1865 0.454689207924458 2624 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2679 rapamycin 1 nM -0.114165556327571 0.451513293792102 no 1866 0.454553277707711 2649 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.116013434504783 0.450805643635877 no 1867 0.45382094724855 2614 165521 SGTC_2991 9074669 71.4286 µM -0.116122486511353 0.450763886726099 no 1868 0.453777733855413 2722 17333109 SGTC_1956 st077085 54 µM -0.118921901466299 0.449692155558117 no 1869 0.4526686150152 2650 24208685 SGTC_676 falcarinol 140 µM -0.119069840603156 0.449635528509882 no 1870 0.452610012219188 2654 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2949 9072542 2.23 µM -0.119938555584081 0.449303028947924 no 1871 0.452265910986394 2698 16457352 SGTC_1820 st053765 18.6 µM -0.120146882037231 0.449223297543982 no 1872 0.452183397423917 2685 3690829 SGTC_1731 st035964 63 µM -0.121056820284064 0.448875066981005 no 1873 0.45182301499645 2695 6739575 SGTC_2004 4023728 41.89 µM -0.121331984875569 0.448769770082465 no 1874 0.451714043444675 2669 360084 YDR527W RBA50 SGTC_1243 0416-0003 5.65 µM -0.122064424752768 0.448489505814086 no 1875 0.451423998040496 2688 2141977 SGTC_2025 5147754 141 µM -0.12543565597533 0.447199855495309 no 1876 0.450089330817207 2707 315777 YLR208W SEC13 SGTC_2340 7987427 183.45 µM -0.127173239016082 0.446535367501551 no 1877 0.449401642776561 2729 2239331 SGTC_1109 tnp00067 928.257 nM -0.127186660572417 0.446530235400263 no 1878 0.449396331478863 2645 676295 SGTC_3348 9149464 3.537 µM -0.128350090369625 0.446085400139554 no 1879 0.448935963245868 2604 1951442 SGTC_1502 4534-4282 27.7 µM -0.131838823315607 0.444751898439519 no 1880 0.44755588899602 2655 3278949 SGTC_2852 9023854 51.95 µM -0.132554539205651 0.44447840644866 no 1881 0.44727284375386 2776 19798528 SGTC_3010 9080089 71.4286 µM -0.132929961367384 0.444334959310594 no 1882 0.447124385712891 2735 17027233 SGTC_1877 wortmannin 25 µM -0.13304601389099 0.444290617631984 no 1883 0.447078495060618 2709 312145 A covalent inhibitor of PI 3-kinase. SGTC_2582 agaric acid 100 µM -0.133574633230113 0.444088650079812 no 1884 0.446869472075778 2701 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1928 4'-methoxychalcone 40.3 µM -0.134077248574301 0.443896631238068 no 1885 0.44667074509646 2864 641818 SGTC_226 1,3-diallylurea 8.28947 mM -0.134805546696496 0.4436184160734 no 1886 0.446382810121494 2746 74537 YKL182W FAS1 SGTC_665 3914-0008 307 µM -0.135130112034642 0.443494438703459 no 1887 0.446254501281387 2647 1069549 SGTC_729 4092-0585 94.1 µM -0.135173387127075 0.44347790891432 no 1888 0.446237393973979 2629 2169061 SGTC_623 k072-0108 16.9 µM -0.135352719171098 0.443409410493417 no 1889 0.446166502334923 2729 5382803 SGTC_830 4076-0286 57.8 µM -0.135856119276235 0.443217138716563 no 1890 0.445967512753494 2677 6866659 SGTC_611 3453-1652 23.7 µM -0.137271719364576 0.442676527388771 no 1891 0.445408011737469 2665 1560575 SGTC_2508 celastrol 40.54 µM -0.13755908783043 0.442566795657839 no 1892 0.445294445618609 2622 122724 Celastrol is a natural product and antioxidant. SGTC_61 0978-8327 98.565 µM -0.138014841935175 0.442392774860516 no 1893 0.445114343817174 2648 6150059 YHR072W ERG7 SGTC_389 tpck 16.7 µM -0.138519313127059 0.442200165357662 no 1894 0.444915003540023 2707 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1933 st074711 15.9 µM -0.139949062302298 0.441654354700208 no 1895 0.444350118291988 2619 17250958 SGTC_2564 betulinic acid 100 µM -0.1424035954247 0.440717588852181 no 1896 0.443380611295916 2840 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_438 sphingosine 6.67 µM -0.144290994460859 0.439997493449813 no 1897 0.442635344636194 2671 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_3265 9137266 49.47 µM -0.144313261970458 0.439988998953237 no 1898 0.442626553195832 2628 17224265 SGTC_2986 9022445 71.43 µM -0.145243110768535 0.43963430965958 no 1899 0.442259464660327 2802 6459286 SGTC_298 1391-0729 10 µM -0.145840943524974 0.439406292909307 no 1900 0.442023476589899 2669 3237558 SGTC_864 0469-0573 172 µM -0.146201088185708 0.439268941422979 no 1901 0.44188132327194 2654 689425 SGTC_310 1273-0058 1.06 µM -0.147777880998878 0.438667672595895 no 1902 0.441259033031056 2736 2734232 SGTC_1834 st055981 52.8 µM -0.150265144088401 0.43771950787639 no 1903 0.440277715848302 2827 471719 YDL150W RPC53 SGTC_2964 9083345 53.42 µM -0.150323045018987 0.437697439812328 no 1904 0.440254876136514 2711 17741579 SGTC_868 0527-0199 213 µM -0.150999627696999 0.437439584936783 no 1905 0.4399880047928 2724 2849450 SGTC_3244 9134489 49.47 µM -0.151044578658112 0.437422454453164 no 1906 0.439970275295416 2764 16584271 SGTC_1710 st031758 61.5 µM -0.151317918645849 0.437318289102873 no 1907 0.439862467499363 2831 5394341 SGTC_1004 4084-0029 199 µM -0.153449724891712 0.436506042614299 no 1908 0.439021817190638 2808 716894 YLR208W SEC13 SGTC_2074 5212007 75.395 µM -0.153822709966821 0.436363957761678 no 1909 0.438874763491076 2684 758611 SGTC_2587 piperic acid 92.2 µM -0.154302897851069 0.436181047186726 no 1910 0.438685456263794 2756 5370536 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.155140708577037 0.435861945551412 no 1911 0.438355194940113 2789 7104 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.15514239114064 0.435861304745983 no 1912 0.438354531724013 2732 4330530 SGTC_2910 7948405 25.97 µM -0.155375615108925 0.435772482877874 no 1913 0.438262603507729 2772 2971328 SGTC_3317 9138495 8.753 µM -0.155675160969465 0.435658407491097 no 1914 0.438144538555046 2691 17020139 SGTC_1308 1187-1617 41.4 µM -0.155901611894435 0.435572172239554 no 1915 0.438055287369082 2652 2882570 SGTC_3096 9117468 49.47 µM -0.15748876007791 0.434967853219371 no 1916 0.437429832757876 2721 41316311 SGTC_1531 st059297 52.4 µM -0.157999308669672 0.434773490089306 no 1917 0.437228671737503 2804 7566702 SGTC_843 0310-0051 143 µM -0.15922190554973 0.434308118119248 no 1918 0.436747022941514 2703 2065037 SGTC_888 0916-0002 6.97 µM -0.160411866614306 0.433855256118187 no 1919 0.436278321229555 2859 2802138 YIL048W NEO1 SGTC_220 paclitaxel 373.376 µM -0.160703364266652 0.433744334433888 no 1920 0.436163519787936 2802 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.160759064001842 0.433723139973509 no 1921 0.436141583996876 2712 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1732 st034308 51.822 µM -0.160856950114264 0.433685893519742 no 1922 0.436103034750769 2642 830119 SGTC_2728 chlorpromazine 9.18 µM -0.160872566472885 0.433679951424033 no 1923 0.436096884814458 2667 2726 A thorazine and dopamine antagonist. SGTC_224 benfluorex 43.875 µM -0.162644026183793 0.433006000529827 no 1924 0.435399360308289 2715 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1120 ficusin 1.78878 µM -0.163252568666145 0.432774525725947 no 1925 0.435159788762314 2832 6199 A DNA cross-linker. SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.163443293783172 0.432701983260082 no 1926 0.43508470882284 2701 2724278 An inhibitor of dopamine biosynthesis. SGTC_2780 5215298 71.43 µM -0.163674405859606 0.432614082618352 no 1927 0.434993733482167 2777 2834131 SGTC_798 1287-0182 476 µM -0.164603639383141 0.432260693754024 no 1928 0.43462798324055 2732 1649755 SGTC_2706 st078239 82.5 µM -0.165803855130029 0.431804330186816 no 1929 0.434155656081979 2698 15434492 SGTC_2229 7354935 190 µM -0.166404654451282 0.431575919628613 no 1930 0.433919255650402 2723 318112 SGTC_266 formosanin C 406 nM -0.167566343252535 0.431134336292207 no 1931 0.433462225473086 2751 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_694 1315-0438 43.2 µM -0.168903013510293 0.430626345196869 no 1932 0.432936464408771 2745 6793154 SGTC_687 k029-0044 34.9 µM -0.168942298108115 0.430611417124263 no 1933 0.432921014137456 2823 5829338 SGTC_2634 4'-methoxyflavone 100 µM -0.169375332407573 0.430446871487551 no 1934 0.432750712526829 2765 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_725 1497-0963 19 µM -0.169692655354992 0.430326301853333 no 1935 0.432625925238795 2806 3549977 SGTC_2008 4012253 172 µM -0.170420474220951 0.430049785250971 no 1936 0.4323397357801 2701 603940 SGTC_1012 4112-3522 18 µM -0.170890333517724 0.429871292157827 no 1937 0.432154998796033 2768 3112398 SGTC_2472 5377652 49.4 µM -0.17100524533065 0.429827640918329 no 1938 0.432109820586394 2750 1610903 SGTC_1587 estradiol valerate 56.1 µM -0.171514293625052 0.429634280443613 no 1939 0.431909696142006 2779 13791 A steroid. SGTC_1493 4348-0038 111 µM -0.171810139459521 0.429521912038993 no 1940 0.43179339696371 2728 800424 SGTC_794 k038-0031 316 µM -0.172780132456809 0.429153528611058 no 1941 0.4314121270825 2706 6624242 SGTC_1013 4112-3890 241 µM -0.173258176797256 0.428971999859504 no 1942 0.431224248271195 2706 705171 SGTC_677 0929-0063 136 µM -0.176959001943986 0.427567189147056 no 1943 0.42977029649537 2705 1539583 SGTC_304 1310-0298 97 µM -0.177214619257278 0.427470192053591 no 1944 0.429669906450164 2712 1550234 SGTC_2909 7941780 10.49 µM -0.178161425488543 0.427110953169266 no 1945 0.429298101506045 2745 1243215 SGTC_2316 5844804 197.44 µM -0.178852855257411 0.426848647838189 no 1946 0.429026620920034 2837 776813 SGTC_1972 st070201 17.4 µM -0.179953048878011 0.426431337897433 no 1947 0.428594713970518 2833 2829099 SGTC_836 0330-0104 1.35 µM -0.181034396777234 0.426021256492748 no 1948 0.428170288668007 2729 46494820 SGTC_2268 7933382 153.85 µM -0.181492993424099 0.425847366234246 no 1949 0.427990316133448 2692 935025 YOR257W CDC31 SGTC_934 2950-0684 338 µM -0.18396348199093 0.424910857522548 no 1950 0.427021051545737 2955 1121253 SGTC_2608 thymoquinone 42.66 µM -0.184761234612266 0.424608537010922 no 1951 0.426708157302422 2691 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_3113 9123498 49.47 µM -0.18620961039552 0.424059766398286 no 1952 0.426140193879995 2711 8897275 SGTC_326 k292-0812 17.5 µM -0.18771198097466 0.423490693420023 no 1953 0.425551218883391 2764 3579357 SGTC_538 2922-0838 53.3 µM -0.187784365577507 0.423463279356204 no 1954 0.425522846099068 2785 777039 SGTC_3198 9112019 49.47 µM -0.187948208227176 0.423401228953037 no 1955 0.425458625686762 2735 45595555 SGTC_2866 9034245 58.44 µM -0.188480706066504 0.423199574775714 no 1956 0.425249919396376 2840 6462273 SGTC_2129 girgensonine 121.053 µM -0.188520524256003 0.423184496641075 no 1957 0.425234313964415 2809 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3278 9139605 49.47 µM -0.188782990073413 0.423085110334093 no 1958 0.425131452037305 2955 7958859 SGTC_941 3237-0776 460 µM -0.190006519551288 0.422621868687535 no 1959 0.424652010867663 2909 760008 SGTC_926 2268-1401 59.4 µM -0.192016256407715 0.421861192813916 no 1960 0.423864735797465 2735 2931578 SGTC_2156 5649887 115 µM -0.192368668096047 0.421727836613387 no 1961 0.423726716632531 2863 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1583 clindamycin 39.6 µM -0.193316338606181 0.4213692729267 no 1962 0.42335561565808 2741 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1036 k216-0215 33.5 µM -0.193496016914177 0.421301296603032 no 1963 0.423285262577996 2742 622330 SGTC_35 0133-0054 64.071 µM -0.194448543092184 0.420940973864724 no 1964 0.422912341653759 2778 99677 SGTC_23 0213-0011 39.996 µM -0.195152740313199 0.420674631854524 no 1965 0.42263668770717 2891 627608 SGTC_2149 5554786 194.827 µM -0.196085005385133 0.42032208571855 no 1966 0.422271816203648 2776 745063 YPR165W RHO1 SGTC_996 3970-0799 1.8 µM -0.196993348546446 0.419978647381062 no 1967 0.421916371444544 2832 6615648 YGL040C HEM2 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.19773849130649 0.419696959477896 no 1968 0.421624836284656 2886 1609 A potent and irreversible inhibitor of serine proteases. SGTC_787 4152-0075 138 µM -0.197749708463062 0.419692719346295 no 1969 0.421620447929201 2783 9566539 SGTC_405 ebelactone b 50 µM -0.19881122928806 0.419291502339027 no 1970 0.421205205818693 2759 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2798 7813637 45.45 µM -0.199269975582662 0.419118138543881 no 1971 0.421025782091435 2891 956368 SGTC_1383 3049-0032 20.7 µM -0.201432269163684 0.418301202951987 no 1972 0.420180292570723 2914 712864 SGTC_2047 4141938 200 µM -0.201762645835833 0.418176414364387 no 1973 0.420051142621126 2784 3807862 SGTC_3287 9117173 37.0625 µM -0.202700841413863 0.417822087735804 no 1974 0.419684432738387 2802 2789709 SGTC_598 3937-0236 20.2 µM -0.203458231417924 0.417536094264567 no 1975 0.419388444679325 2844 1379313 SGTC_1086 cerivastatin 2.18 µM -0.205238255659274 0.4168641220106 no 1976 0.41869299093651 2754 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1263 0774-1208 64.8 µM -0.205908779426147 0.416611057209504 no 1977 0.418431083705255 2892 906585 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.207050618980277 0.416180190993229 no 1978 0.417985163347271 2769 368090 SGTC_756 0508-1999 28.3 µM -0.207379305886236 0.416056181632347 no 1979 0.417856821410108 2788 6753853 SGTC_2757 clomiphene 4.22 µM -0.207404716046398 0.416046595052139 no 1980 0.41784689990292 2972 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1105 epirubicin 18.1 µM -0.208667983528337 0.415570060784978 no 1981 0.417353717680779 2767 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1217 1183-1422 255 µM -0.209588018091105 0.415223080153161 no 1982 0.416994616061579 2902 2849664 SGTC_1461 k072-0203 53.8 µM -0.209653767697191 0.415198285960572 no 1983 0.4169689557709 2746 5418714 SGTC_45 0kpi-0036 14.9 µM -0.210906255783022 0.414726036997464 no 1984 0.416480211258576 2898 2795021 SGTC_857 0438-0306 1.35 µM -0.211797619422387 0.414390024531696 no 1985 0.41613246290941 2876 4686136 SGTC_3275 9138069 49.47 µM -0.212491617412707 0.414128455273015 no 1986 0.415861758403258 2854 17617007 SGTC_39 0986-0283 58.349 µM -0.213905066703052 0.413595841244057 no 1987 0.415310544511544 2939 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_905 2-aminofluorene 215 µM -0.214764999226597 0.41327188034355 no 1988 0.414975271349249 2786 1539 An established DNA mutagen. YPR165W RHO1 SGTC_57 miconazole 162.5 nM -0.215441739153739 0.413016974776994 no 1989 0.414711465407664 2739 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_695 3505-6186 243 µM -0.215895436131395 0.412846102643975 no 1990 0.414534627327267 2915 1819379 SGTC_1895 st058434 18.3 µM -0.216406823260546 0.412653522943673 no 1991 0.414335324045083 2973 5393175 SGTC_2891 9063876 19.48 µM -0.216653835977968 0.412560509679997 no 1992 0.414239063493366 2889 6472478 SGTC_2825 7998094 58.44 µM -0.218798614626025 0.411753094800387 no 1993 0.413403463049165 2869 2987815 SGTC_2201 6605497 169.863 µM -0.219477270776754 0.41149768822072 no 1994 0.413139141771673 2825 670741 SGTC_1124 fisetin 1.16336 µM -0.21953467098196 0.411476087850881 no 1995 0.413116787489264 2857 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2117 5521686 200 µM -0.220505815264822 0.411110675599658 no 1996 0.412738621953525 2772 803312 SGTC_1892 st058411 7.36 µM -0.220815183268636 0.410994285947155 no 1997 0.412618170420777 2925 3934738 SGTC_1656 st012921 11 µM -0.221710292861127 0.410657574232247 no 1998 0.412269708486849 2918 6732821 SGTC_2479 5617353 43.85 µM -0.222470294530173 0.410371737480327 no 1999 0.411973897697716 2948 2731746 SGTC_3250 9135583 49.47 µM -0.225235370492043 0.409332194705036 no 2000 0.410898087310531 2940 7699353 SGTC_3221 9128209 49.47 µM -0.226734889065761 0.408768709953018 no 2001 0.410314947993722 2847 16460723 SGTC_705 1124-0212 310 µM -0.230405663617514 0.407390114766371 no 2002 0.408888280303464 2916 9554485 SGTC_2628 lathosterol 100 µM -0.230428809926319 0.407381425563292 no 2003 0.408879288164599 2958 6710616 SGTC_1317 1273-0028 910 nM -0.231677276778655 0.406912814489729 no 2004 0.408394340871857 2847 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_708 3448-5400 146 µM -0.231694993090946 0.406906165642736 no 2005 0.408387460256787 2873 3462195 SGTC_1477 0139-0234 16 µM -0.232357947604807 0.40665738129856 no 2006 0.408130004036 2806 620880 SGTC_895 0964-0006 13.7 µM -0.233901765628362 0.406078184912031 no 2007 0.407530621228808 2929 6738897 SGTC_1695 st026914 34.495 µM -0.233961414834549 0.406055810350423 no 2008 0.407507466933337 2788 3289191 SGTC_71 0417-1750 47.813 µM -0.234051359785528 0.406022072361803 no 2009 0.407472553215988 3037 6811472 SGTC_2926 9010726 65.15 µM -0.235824715518653 0.405357036603387 no 2010 0.406784344383633 2931 2994293 SGTC_2483 5729050 27.16 µM -0.236501358582802 0.405103356905869 no 2011 0.406521826591066 2968 2865180 SGTC_3002 9075603 71.4286 µM -0.236846854354594 0.404973842737511 no 2012 0.40638780049189 2828 20105405 SGTC_2734 clemastine 41.6 µM -0.237438221193023 0.40475218434628 no 2013 0.406158420565901 2814 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.239710655841396 0.40390070660257 no 2014 0.405277286798247 2918 756377 SGTC_1361 1608-0041 5.61 µM -0.239804118570866 0.403865695980447 no 2015 0.405241056982994 2848 X1361 SGTC_1248 0469-0687 58.6 µM -0.240356962415532 0.403658619490585 no 2016 0.405026769668652 2937 4017482 SGTC_1426 4048-4480 71.7 µM -0.242141694192981 0.402990304278597 no 2017 0.404335185999226 2939 14224343 SGTC_744 1594-0068 283 µM -0.24231534701035 0.402925292894383 no 2018 0.404267911440255 2878 668392 SGTC_1162 k048-0130 20.1 µM -0.243977365342256 0.402303209725924 no 2019 0.403624175064019 2842 6797406 SGTC_3048 9093155 49.47 µM -0.246463264163864 0.401373215291983 no 2020 0.402661819207605 2910 25236002 SGTC_2862 9027634 71.43 µM -0.246493395285643 0.401361946415517 no 2021 0.402650158273763 2803 5012562 SGTC_1509 1326-1131 80 µM -0.247139630198435 0.401120277819491 no 2022 0.402400082157957 2907 768313 SGTC_467 ro 31-8220 72.8 µM -0.247406960724707 0.401020316880823 no 2023 0.402296643863966 2903 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_513 4245-1575 41.7 µM -0.249207659759294 0.400347163852684 no 2024 0.401600077339687 2965 719745 SGTC_2413 inermin 26.06 µM -0.249375119684883 0.400284577530733 no 2025 0.401535314470055 3140 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_99 0109-0120 622.8 µM -0.249411388167611 0.400271022917912 no 2026 0.401521288479329 3002 759414 SGTC_3352 9151559 45.5865 µM -0.249680334271945 0.400170513493108 no 2027 0.401417283799193 2929 17159339 SGTC_119 0121-0043 24.815 µM -0.250254333561006 0.39995602297722 no 2028 0.401195334765477 2840 1092378 SGTC_1415 3966-0071 78.1 µM -0.251643498210233 0.39943704867589 no 2029 0.400658316780272 2868 2893185 SGTC_3284 9108171 64.8615 µM -0.252155054361615 0.399245982488729 no 2030 0.400460608583273 2968 8687505 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.252444654100372 0.399137827701565 no 2031 0.400348694259333 3269 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3089 9117425 49.47 µM -0.25507824232275 0.398154636260969 no 2032 0.399331334276819 2915 9401657 SGTC_3178 9107506 49.47 µM -0.257196654368549 0.397364243044975 no 2033 0.398513483293641 3002 8897194 SGTC_318 1488-0629 67.2 µM -0.258702110320246 0.396802803560424 no 2034 0.39793254559145 2938 3662576 SGTC_1491 4138-0063 26.5 µM -0.258850889947854 0.39674732979838 no 2035 0.397875145549784 2882 23883227 SGTC_252 miconazole 1.30953 nM -0.259685638803905 0.396436125299177 no 2036 0.397553135636499 2966 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_17 0960-0276 49.807 µM -0.26154108488918 0.39574462904256 no 2037 0.396837635282127 2882 6821114 SGTC_1748 st037455 53.6035 µM -0.261946116540251 0.395593723509877 no 2038 0.396681492350052 3045 580690 SGTC_732 3970-1727 52.7 µM -0.262248273528042 0.39548115691652 no 2039 0.396565019208377 2986 1275699 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.262405281309801 0.395422668144667 no 2040 0.396504500704576 2875 16623 A steroid. SGTC_2235 salicylic acid 500 µM -0.265059681534548 0.394434204576138 no 2041 0.395481743105458 2868 338 A COX inhibitor and kinase inhibitor. SGTC_2841 9004761 38.96 µM -0.265322443441125 0.394336392366191 no 2042 0.395380538259742 2894 2991039 SGTC_1174 0739-0097 51.1 µM -0.265982317089013 0.394090786073224 no 2043 0.395126413778535 2923 728447 SGTC_894 0960-0238 55.9 µM -0.266057836723088 0.394062680197938 no 2044 0.395097333192576 2866 6741907 YDL195W SEC31 SGTC_2639 lactacystin 53 µM -0.266598720705236 0.393861397452193 no 2045 0.394889070363251 3018 3870 A proteasome inhibitor. SGTC_2854 9024559 71.43 µM -0.266925149922487 0.393739934896292 no 2046 0.394763396064422 2966 3163529 SGTC_554 4483-2211 187 µM -0.268977992245794 0.392976320685482 no 2047 0.393973309201412 2990 747107 SGTC_1953 st076800 12.1 µM -0.270433700460484 0.392435077089871 no 2048 0.393413308201201 2912 297591 SGTC_1278 0874-0585 172 µM -0.271034062326735 0.3922119184132 no 2049 0.393182417228501 2947 766306 SGTC_2522 biochanin a 4.94 µM -0.271363398779891 0.392089516815851 no 2050 0.393055774878866 3008 5280373 A possible chelator. SGTC_1611 st001856 99.4 µM -0.271692879995138 0.391967072100596 no 2051 0.392929088187687 2908 647478 SGTC_2779 methotrexate 400 µM -0.272805148610105 0.391553800113046 no 2052 0.392501500809019 2975 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1293 1000-1278 195 µM -0.275025118790812 0.390729319331686 no 2053 0.391648470081876 3026 678847 SGTC_1790 st045711 43.5 µM -0.275594234041884 0.390518032989916 no 2054 0.391429869396904 3062 585119 SGTC_361 000s-0510 1.45 µM -0.275887220119206 0.390409273322669 no 2055 0.391317344997759 2974 660 SGTC_2040 5100729 123 µM -0.276146834865676 0.390312908627408 no 2056 0.391217644810791 2889 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2972 9093619 59.92 µM -0.278012523140982 0.389620594587708 no 2057 0.390501372747783 2875 25236256 SGTC_2296 7971656 126.45 µM -0.278241396968618 0.389535688836352 no 2058 0.390413529404111 2973 666570 SGTC_3188 9110789 49.47 µM -0.27909528069943 0.389218968552281 no 2059 0.390085852375251 3062 849217 SGTC_571 k831-0106 44.2 µM -0.279554652104547 0.389048610160737 no 2060 0.389909601345435 2981 4783639 SGTC_1403 3909-7815 62.9 µM -0.280060920965112 0.388860884502441 no 2061 0.389715382977993 2877 6615483 SGTC_4 0960-0234 25.671 µM -0.280242201161047 0.388793671695211 no 2062 0.389645845706099 2978 6821112 SGTC_1712 st032288 53.4 µM -0.280622059339411 0.388652843420734 no 2063 0.389500147363217 2991 2883011 SGTC_1558 st069300 45.6 µM -0.282874948069446 0.387817910844475 no 2064 0.38863634956275 3009 24208000 SGTC_1209 2323-2347 50.3 µM -0.288023247109744 0.385911875332564 no 2065 0.386664471863871 2982 5412760 SGTC_537 1334-0398 209 µM -0.288887782420508 0.385592070175363 no 2066 0.386333626761944 3081 5846986 SGTC_85 0868-0259 160.055 µM -0.289516440258668 0.385359568609765 no 2067 0.386093100410657 2965 83173 SGTC_251 melphalan 456.522 µM -0.291127364138328 0.384763975942314 no 2068 0.385476956168155 2981 460612 A DNA alkylator. SGTC_2125 5246583 200 µM -0.292883488678054 0.384115009241061 no 2069 0.384805604927309 3065 835267 SGTC_2063 5246145 200 µM -0.295913303007403 0.382996121521848 no 2070 0.383648145736635 3046 711240 SGTC_3128 9127691 49.47 µM -0.298755358897817 0.381947458027119 no 2071 0.382563357273459 3067 41316314 SGTC_1223 0764-0573 147 µM -0.298981378007691 0.381864098415669 no 2072 0.382477127124994 2920 1609797 SGTC_486 niguldipine 82 µM -0.299704976965777 0.381597259925901 no 2073 0.382201100979414 2931 1236 A calcium channel blocker. SGTC_2130 NSC 7 2.4545 µM -0.299747642028455 0.381581528268603 no 2074 0.382184827708876 3051 21448 SGTC_2432 5630864 12.22 µM -0.301241787909604 0.381030723506991 no 2075 0.3816150633608 3072 5714970 SGTC_824 1304-0008 100 µM -0.302684049728707 0.380499273914641 no 2076 0.381065327200895 2949 768245 SGTC_2457 5731572 11.68 µM -0.303435725712346 0.380222383071375 no 2077 0.38077891152842 3069 2865357 SGTC_3138 9097216 49.47 µM -0.305345103076978 0.379519312230412 no 2078 0.380051663891838 2903 25237486 SGTC_2820 7989630 71.43 µM -0.305490484551075 0.379465796155591 no 2079 0.379996308027966 3009 2984098 SGTC_567 1080-0542 68.4 µM -0.307740277963924 0.37863792429989 no 2080 0.379139984331975 2987 5950415 SGTC_881 0833-0569 170 µM -0.307905747688592 0.37857705720373 no 2081 0.379077026056828 2957 5418700 SGTC_1277 0873-0036 22 µM -0.307927627082681 0.378569009218616 no 2082 0.379068701578186 3019 5965735 SGTC_2515 chrysin 20.77 µM -0.308753325929792 0.378265327632351 no 2083 0.378754588000925 3022 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1465 k213-0056 144 µM -0.310171068906518 0.3777440751729 no 2084 0.378215434996241 2927 24048857 YMR208W ERG12 SGTC_3030 9087619 49.47 µM -0.311704149594675 0.377180667688681 no 2085 0.377632687027917 3001 25236973 SGTC_1527 coumarin 137 µM -0.314490087103813 0.376157504769234 no 2086 0.376574422088798 3135 323 A hepatotoxic, DNA x-linker. SGTC_2239 6685329 187.64 µM -0.317781935455187 0.37494966255437 no 2087 0.375325177190346 3098 805680 SGTC_290 2043-6722 48.1 µM -0.318346444476858 0.374742656146933 no 2088 0.375111078858187 3053 773758 YLR208W SEC13 SGTC_3119 9125183 49.47 µM -0.320873557977079 0.373816402534212 no 2089 0.374153106453119 3001 22695334 SGTC_865 0488-0499 301 µM -0.321455386720804 0.373603249927931 no 2090 0.373932657911864 3137 9634651 SGTC_1561 5-methoxyflavone 52.9 µM -0.322222017720648 0.373322454164319 no 2091 0.37364225277842 2986 94525 SGTC_1647 st011722 22.4 µM -0.323425349298501 0.372881842724449 no 2092 0.373186567154174 3128 2854783 SGTC_511 blebbistatin 171 µM -0.324211444480614 0.37259409614162 no 2093 0.372888979103872 3108 3476986 A myosin inhibitor. SGTC_27 0485-0001 32.618 µM -0.324459098228077 0.372503458327554 no 2094 0.372795241786775 2966 2054479 SGTC_107 0358-0022 2.6945 µM -0.324482435100769 0.372494917721892 no 2095 0.372786409133476 3058 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3104 9120930 49.47 µM -0.325976086601588 0.371948416017446 no 2096 0.372221223958798 3076 17014836 SGTC_581 0958-0271 211 µM -0.326677837926748 0.371691746104013 no 2097 0.371955782078819 2989 4591145 SGTC_1378 2093-0007 380 nM -0.326737066275668 0.371670085574978 no 2098 0.371933381363748 3098 3618014 SGTC_1824 st053723 68.6 µM -0.326987374667562 0.371578549232874 no 2099 0.371838717178773 3044 675225 SGTC_1100 amiodarone 5.07 µM -0.327426097799452 0.371418128221416 no 2100 0.371672815076248 3093 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_52 0329-0193 875 nM -0.327588130732221 0.371358885824171 no 2101 0.371611548734729 3184 3739292 SGTC_2100 5377183 190 µM -0.327722849624082 0.37130963229263 no 2102 0.371560612592707 3057 2844202 SGTC_747 3448-8087 38.7 µM -0.328918014518384 0.370872769669021 no 2103 0.371108828812799 3033 5168703 SGTC_2257 7960413 200 µM -0.330907520511902 0.370145924791587 no 2104 0.370357170578351 2976 2974689 YIL048W NEO1 SGTC_1622 st003707 19.4 µM -0.331981277310285 0.369753831559949 no 2105 0.369951698289107 3120 10140899 SGTC_433 pimozide 108 µM -0.332274535958862 0.369646768696248 no 2106 0.369840982997063 2933 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2456 5770359 74.46 µM -0.332701109888643 0.369491053133531 no 2107 0.369679955832234 3139 3118787 SGTC_3306 9127676 59.7925 µM -0.333644501727764 0.369146755601776 no 2108 0.369323916540472 3059 41905287 SGTC_301 4119-0100 24.5 µM -0.33538379465069 0.368512263620296 no 2109 0.368667795397757 3010 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_3303 9125618 40.5795 µM -0.335471727121352 0.368480195461945 no 2110 0.368634634390145 3068 22695467 SGTC_1802 st050112 57.9 µM -0.336176620531206 0.368223160479724 no 2111 0.368368841044638 2990 4662563 SGTC_1504 k297-0033 30 µM -0.337897682604159 0.367595833916368 no 2112 0.367720146986751 2954 4388117 SGTC_3125 9127534 49.47 µM -0.33859514169026 0.367341710758117 no 2113 0.367457371505208 3064 1639235 SGTC_371 0195-0006 7.36 µM -0.338871875748652 0.367240897231455 no 2114 0.36735312605298 2914 3928593 SGTC_655 k060-0012 42 µM -0.339976225644207 0.36683867651373 no 2115 0.366937215928606 3008 5994525 SGTC_2853 9015042 58.44 µM -0.340597363966282 0.3666125128537 no 2116 0.366703357085392 2918 6457456 SGTC_2407 paclitaxel 400 µM -0.343077164593246 0.365710050879657 no 2117 0.365770204876781 3202 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1463 k081-0032 34.1 µM -0.34383092140082 0.365435886730353 no 2118 0.365486722237073 3071 977755 SGTC_1783 st039459 87.517 µM -0.345518134482556 0.364822445635871 no 2119 0.364852439711047 3203 729761 SGTC_2916 7875993 68.79 µM -0.346514465163973 0.364460359596859 no 2120 0.364478057585283 3113 1299250 SGTC_3315 9136395 68.55 µM -0.346573996504443 0.364438728569254 no 2121 0.364455692122719 3229 16876844 SGTC_2377 9073351 62.6 µM -0.346767070579334 0.364368577053154 no 2122 0.3643831588668 2993 7337946 YHR072W ERG7 SGTC_2246 7293507 91.5585 µM -0.348708457808057 0.363663446462466 no 2123 0.36365409698426 3165 887656 SGTC_3175 9106517 49.47 µM -0.348741583533324 0.363651418877425 no 2124 0.363641661337644 3094 41468073 SGTC_1699 st031318 29.054 µM -0.34891982403403 0.363586704026928 no 2125 0.363574750978417 3120 5340658 SGTC_1603 st002045 67.8 µM -0.350433232048696 0.363037378871674 no 2126 0.363006795009646 3145 5887985 SGTC_2877 9040724 71.43 µM -0.351353936344828 0.362703326455076 no 2127 0.362661417793952 3208 6463895 SGTC_1520 flindersine 88 µM -0.351796887549731 0.362542650909065 no 2128 0.362495296461206 3280 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3149 9097855 49.47 µM -0.352004394032315 0.362467388600688 no 2129 0.362417483577697 3158 25236625 YMR079W SEC14 SGTC_697 0508-1955 564 µM -0.352440756211909 0.362309137996613 no 2130 0.362253870611863 3178 6243113 SGTC_1460 k062-0059 9.15 µM -0.353108531153117 0.362067009067324 no 2131 0.362003538701614 2929 1373085 SGTC_2568 diosmetin 100 µM -0.355179386154688 0.36131648779857 no 2132 0.361227603367787 3192 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3060 1327-0027 12.5 µM -0.355863194157751 0.361068778450324 no 2133 0.360971510296828 3084 16000455 YPR107C YTH1 SGTC_1623 st003709 20.3 µM -0.356835158725898 0.360716784693915 no 2134 0.360607606908427 3014 16192618 SGTC_1632 st005650 90 µM -0.357768962862748 0.360378721711421 no 2135 0.360258109632855 3139 2759605 SGTC_596 1155-0152 116 µM -0.358619308570443 0.360070967913692 no 2136 0.359939950109479 3060 280313 SGTC_1458 k015-0034 6.33 µM -0.359730425345412 0.359668973534876 no 2137 0.359524368494245 3083 3598957 SGTC_2089 5281248 129.67 µM -0.360026200525892 0.359561990256574 no 2138 0.359413770173714 3059 2737878 SGTC_2693 st077581 40.7 µM -0.360585647191547 0.359359665859701 no 2139 0.359204610181048 3176 25238761 SGTC_1751 st044839 27.194 µM -0.36320635318099 0.358412410916986 no 2140 0.358225371040714 3080 5291326 SGTC_1434 4073-0095 163 µM -0.363382218558355 0.358348875432646 no 2141 0.358159691406388 3118 24133745 SGTC_1473 k844-0725 134 µM -0.363946520987485 0.358145034457343 no 2142 0.357948972320909 3085 54682906 SGTC_3329 9141233 27.5565 µM -0.364277803654292 0.358025385218588 no 2143 0.357825286503628 3183 4909101 YNL103W MET4 SGTC_3174 9107204 49.47 µM -0.365575347250904 0.357556886237136 no 2144 0.357340986809324 3175 3938802 SGTC_519 k048-0011 62.8 µM -0.366835819137889 0.35710197802857 no 2145 0.35687074380658 3131 6836379 SGTC_2050 5263056 171 µM -0.367184653649224 0.356976118420719 no 2146 0.356740642837297 3199 763468 YGL055W OLE1 SGTC_1233 0325-0408 14.2 µM -0.36856317129749 0.356478901194841 no 2147 0.356226675445433 3161 12874 SGTC_271 rotenone 740 µM -0.368563805929092 0.3564786723458 no 2148 0.356226438889042 3166 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_296 1222-0039 74.9 µM -0.368942353195257 0.356342176884808 no 2149 0.356085346772277 3081 5984176 SGTC_473 2-arachidonoylglycerol 10 µM -0.369533036929083 0.356129226645376 no 2150 0.355865226529894 3003 5282280 An endocannabinoid. SGTC_2430 5571206 200 µM -0.369588123024422 0.356109369577898 no 2151 0.355844700962753 3210 1731771 SGTC_2543 pimpinellin 60.67 µM -0.369868097286672 0.356008452360192 no 2152 0.355740386532616 3048 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1374 2889-5571 141 µM -0.371651417772788 0.355365888359138 no 2153 0.355076200486112 3114 2853281 SGTC_2405 ticlatone 3.52 µM -0.374058921693705 0.354499071403578 no 2154 0.354180239793317 2881 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_21 0849-0113 22.993 µM -0.374594841696606 0.35430621679707 no 2155 0.353980904947904 3065 1560156 SGTC_2933 9026794 32.47 µM -0.375149239194956 0.354106752241949 no 2156 0.353774739525494 3083 17586027 SGTC_1164 k060-0068 93.7 µM -0.375328478717444 0.354042272899171 no 2157 0.353708094367827 3065 5963676 SGTC_3220 9131269 49.47 µM -0.375841861741029 0.353857612467702 no 2158 0.353517232197055 3125 17722206 SGTC_1472 k841-0093 193 µM -0.378236482229445 0.352996738258218 no 2159 0.352627463061728 3201 X1472 SGTC_1255 0566-0045 221 µM -0.380727421806363 0.352102034852868 no 2160 0.351702759485567 3220 2788469 SGTC_76 0433-0009 400.328 µM -0.381665384811464 0.351765346143422 no 2161 0.351354789372339 3154 2841569 SGTC_3267 9137951 49.47 µM -0.383292140804383 0.35118168583717 no 2162 0.350751582932349 3020 16643986 SGTC_1661 st013063 9.66 µM -0.384690759768928 0.350680158744649 no 2163 0.35023327099576 3093 721395 SGTC_2957 9076800 11.52 µM -0.385366023326267 0.350438110818126 no 2164 0.34998312591078 3106 16459615 SGTC_2091 4-phenylthiadiazole 200 µM -0.386462759956576 0.350045115482809 no 2165 0.349576988799544 3070 270010 SGTC_1818 st052136 56.3 µM -0.387416405925108 0.349703524523274 no 2166 0.349223980059995 3183 674169 SGTC_2238 6671620 73.2395 µM -0.388183489740893 0.349428847398558 no 2167 0.348940125180741 3010 729941 SGTC_2080 5212524 12.4 µM -0.388453539323809 0.349332166884447 no 2168 0.348840215017721 3203 260183 SGTC_3297 9117502 71.43 µM -0.390040870002564 0.348764084033875 no 2169 0.348253162813051 3179 7453720 SGTC_285 1486-1325 46 µM -0.390748198646425 0.348511050348094 no 2170 0.34799168409303 3204 22310230 SGTC_790 1575-0012 79.1 µM -0.391246028729356 0.348333001280588 no 2171 0.347807694185364 3233 378741 YLR208W SEC13 SGTC_1329 1447-1697 50.6 µM -0.393924836010571 0.3473754996728 no 2172 0.346818266695146 3176 2840515 SGTC_3033 9090887 49.47 µM -0.394249830464761 0.347259401096805 no 2173 0.346698299639582 3103 19325384 SGTC_187 1488-2104 32.728 µM -0.394494860667682 0.347171877823982 no 2174 0.346607860406151 3169 2852859 SGTC_2434 5670830 169.91 µM -0.39514278904727 0.346940481096822 no 2175 0.346368755913359 3184 1549830 SGTC_2869 9037858 32.47 µM -0.395805433071037 0.346703887951229 no 2176 0.346124284228539 3056 27187042 SGTC_1117 retinoic acid 1.10837 µM -0.397087645884374 0.346246251216283 no 2177 0.345651414892829 3251 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2314 7727897 200 µM -0.397750777141451 0.346009659917818 no 2178 0.345406952036237 3087 900724 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.39789588628875 0.345957896034855 no 2179 0.345353466248776 3288 94937 An inhibitor of serotonin biosynthesis. SGTC_1738 st035555 74 µM -0.398053849050592 0.345901550234456 no 2180 0.345295246257471 3201 5331140 SGTC_2122 5258151 111.688 µM -0.39831275378554 0.345809205503874 no 2181 0.345199830220286 3119 2173356 SGTC_1881 5652484 16 µM -0.398350939487652 0.345795586411658 no 2182 0.345185758199396 3222 2255129 SGTC_1070 indatraline 8.81 µM -0.398701332448702 0.345670626597288 no 2183 0.345056642978299 3125 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2586 curcumin 80 µM -0.400340356799946 0.34508632866532 no 2184 0.344452923677524 3205 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3322 9139058 2.11 µM -0.401002298427538 0.344850456795464 no 2185 0.344209215852031 3275 4908926 YPR165W RHO1 SGTC_205 1486-1330 71.903 µM -0.402437231293996 0.344339349470214 no 2186 0.343681137136917 3128 4118834 SGTC_3086 9117350 49.47 µM -0.405497321316032 0.343250329057524 no 2187 0.342555993511405 3165 2679265 SGTC_86 0417-1630 471.922 µM -0.406649948781426 0.342840470309498 no 2188 0.342132553061596 3209 3634867 SGTC_1128 3448-9350 235 µM -0.407290648195025 0.342612726176078 no 2189 0.341897265259642 3173 619386 SGTC_1511 0906-3109 28.5 µM -0.408230015689073 0.34227892039184 no 2190 0.341552406837537 3127 2882180 SGTC_869 0564-0080 44.1 µM -0.411200300430473 0.341224236473322 no 2191 0.340462834001083 3154 6843321 SGTC_2536 dehydroabietamide 32.04 µM -0.411467666714359 0.34112936115307 no 2192 0.340364822658822 3273 3983547 SGTC_2954 9074818 52.69 µM -0.413058433370115 0.340565083079462 no 2193 0.339781901280311 3269 16648742 SGTC_1061 3448-9325 110 µM -0.413124712843342 0.340541580101033 no 2194 0.339757622095586 3209 723482 SGTC_2187 6125751 200 µM -0.413476643904889 0.340416794249279 no 2195 0.339628715504021 3168 874498 SGTC_1939 st074455 53.6 µM -0.4139838825502 0.340236970995026 no 2196 0.339442955287004 3319 1644229 SGTC_2705 st078069 42.8 µM -0.418226320191721 0.338734392951019 no 2197 0.337890826905292 3198 1530061 SGTC_1984 st072354 53.1 µM -0.41949007812223 0.33828729204078 no 2198 0.337429002214404 3075 5762938 SGTC_1074 carmofur 3.8 µM -0.419820398927425 0.338170466437944 no 2199 0.337308330889977 3139 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_612 0302-0167 22.4 µM -0.420309552057422 0.337997494726277 no 2200 0.337129666388006 3195 235821 SGTC_2342 7990637 118.86 µM -0.421602433252018 0.337540477726729 no 2201 0.33665761496503 3250 2033102 YER133W GLC7 SGTC_936 3005-4620 401 µM -0.423848532183665 0.336747080209212 no 2202 0.335838140646647 3333 777207 SGTC_382 3229-0966 23.2 µM -0.424235438012694 0.336610485291171 no 2203 0.335697059252582 3295 5722370 SGTC_1633 st005664 67.9 µM -0.424678639503505 0.336454041996192 no 2204 0.335535478655651 3097 2063822 SGTC_129 0088-0017 176.636 µM -0.42832803684913 0.33516693933904 no 2205 0.334206154702297 3273 182446 SGTC_884 0851-0618 334 µM -0.428442407300821 0.335126633289133 no 2206 0.334164527773975 3255 9642473 SGTC_2881 9058953 51.95 µM -0.429553628167498 0.334735119456626 no 2207 0.333760187678232 3119 17122249 SGTC_1323 1348-1351 11.2 µM -0.430671626095104 0.334341399103857 no 2208 0.333353576339139 3163 6989654 SGTC_1384 3089-0840 101 µM -0.431496558218097 0.334051003197517 no 2209 0.333053677323263 3258 1069836 SGTC_3211 9128781 49.47 µM -0.431833775323104 0.333932323273731 no 2210 0.332931114835235 3208 17194361 SGTC_3169 9102970 49.47 µM -0.431958762215993 0.33388833970243 no 2211 0.332885692536424 3260 17027839 SGTC_1444 4112-3581 28 µM -0.436022763724902 0.332459441749849 no 2212 0.33141010683213 3189 2877249 SGTC_2870 9038528 12.99 µM -0.436170439414549 0.33240756481533 no 2213 0.33135653679375 3276 6463316 SGTC_383 2324-0395 7.37 µM -0.436339702110099 0.332348108538568 no 2214 0.331295140213211 3285 3146421 SGTC_2376 9072922 81.32 µM -0.438316783288287 0.331653939363351 no 2215 0.330578330635903 3301 17087968 SGTC_2815 7968870 71.43 µM -0.43919895389093 0.331344388386835 no 2216 0.330258691496112 3172 2977326 YHR190W ERG9 SGTC_994 3910-0338 138 µM -0.439236722498696 0.331331138067462 no 2217 0.330245009462086 3331 3479481 SGTC_937 3122-0005 46.7 µM -0.440278504800172 0.330965734008088 no 2218 0.329867703538155 3304 759535 SGTC_1372 2752-0194 270 µM -0.442885032330153 0.330052202956768 no 2219 0.328924447107899 3239 823334 SGTC_1093 fluphenazine 7.97 µM -0.44308509977097 0.329982125451641 no 2220 0.328852091128518 3201 6602611 An atypical antipsychotic. SGTC_2315 7733312 200 µM -0.443459885555594 0.329850865511584 no 2221 0.328716564135294 3151 726316 SGTC_2179 6298986 200 µM -0.443776480647295 0.329740001820246 no 2222 0.328602097136488 3285 738374 SGTC_1879 gemcitabine 100 µM -0.445545101046926 0.329120950543542 no 2223 0.327962937120563 3187 60750 A nucleoside analog which inhibits DNA replication. SGTC_42 0133-0086 60.653 µM -0.445994335344261 0.328963784381582 no 2224 0.327800668889838 3139 162923 Model of phenazepam hydroxylation. SGTC_315 k915-0449 187 µM -0.446287633810763 0.328861189217029 no 2225 0.327694743887095 3239 20970215 YNL149C PGA2 SGTC_2351 9026858 72.31 µM -0.447067729719666 0.328588376138796 no 2226 0.327413079050024 3122 1409300 SGTC_2262 9014885 67.46 µM -0.448821182003134 0.327975497016892 no 2227 0.326780328604414 3170 6457424 SGTC_2288 7946289 167.31 µM -0.449397155743387 0.327774279502448 no 2228 0.3265725913663 3357 1246052 SGTC_1139 k015-0024 46.9 µM -0.450590713032266 0.327357467208164 no 2229 0.326142280628251 3298 2766652 SGTC_3014 9081533 49.47 µM -0.451759877824471 0.326949381802201 no 2230 0.325720988380561 3313 21367265 SGTC_2310 7668677 200 µM -0.45365968706459 0.326286713491539 no 2231 0.325036893218444 3390 2197143 SGTC_1202 1988-0068 29.6 µM -0.455438772533506 0.325666651354294 no 2232 0.324396803346918 3193 2850480 SGTC_1540 guanosine 70.6 µM -0.459233127188752 0.324345822267817 no 2233 0.323033381979562 3275 6802 Guanosine is a purine nucleoside SGTC_3031 9088762 49.47 µM -0.46164138953253 0.323508640855318 no 2234 0.322169254080497 3160 205253 SGTC_2807 7945238 51.95 µM -0.46198994091375 0.323387548191885 no 2235 0.322044267014093 3271 17148797 SGTC_3066 9117245 49.47 µM -0.462165820345004 0.3233264517934 no 2236 0.321981206034236 3226 17176980 SGTC_2162 5663267 200 µM -0.462552812633226 0.32319203650467 no 2237 0.321842469297235 3348 6456493 SGTC_616 4092-0450 108 µM -0.464423298810082 0.322542680102378 no 2238 0.321172250362604 3263 787165 SGTC_2182 6325192 200 µM -0.464511640393382 0.322512024875227 no 2239 0.321140610829692 3306 736248 SGTC_886 0866-0150 153 µM -0.464616615730819 0.322475599172832 no 2240 0.32110301560675 3365 271463 SGTC_49 0717-0965 32.132 µM -0.465142465258372 0.32229315874629 no 2241 0.320914718689001 3453 5889349 YGL099W LSG1 SGTC_1724 st037281 8.293 µM -0.465243422639904 0.322258137067531 no 2242 0.320878572999882 3201 574124 YDL195W SEC31 SGTC_112 phenothiazine 287.218 µM -0.465435756309751 0.322191421716081 no 2243 0.320809716630885 3352 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1257 0669-0121 16 µM -0.46750923070326 0.321472553613531 no 2244 0.320067794744476 3272 4307855 SGTC_856 0433-0016 11.3 µM -0.467744064973627 0.32139117926155 no 2245 0.319983812604493 3296 3911780 SGTC_2354 9060492 162 µM -0.467955152145887 0.321318041026961 no 2246 0.31990833084552 3336 6471895 SGTC_3193 9111931 49.47 µM -0.468012779016013 0.321298075467727 no 2247 0.319887725594961 3200 17087244 SGTC_1979 st071809 45.3 µM -0.468585642997211 0.32109962757462 no 2248 0.319682920721509 3351 4976333 SGTC_2861 9024595 19.48 µM -0.469142323095312 0.320906834934744 no 2249 0.319483954417421 3231 16482810 SGTC_845 0330-0138 4.51 µM -0.469805650927201 0.320677170482772 no 2250 0.319246938363799 3277 9039800 SGTC_641 4092-0595 30 µM -0.470819904854221 0.320326137354588 no 2251 0.318884674463415 3315 786260 SGTC_1480 1070-0044 41.2 µM -0.470870215514606 0.320308729023982 no 2252 0.318866709364579 3294 3124987 SGTC_1471 k673-0312 37 µM -0.471671037104561 0.320031684614412 no 2253 0.318580806639027 3292 24099884 SGTC_2341 7987486 176.74 µM -0.471708528935676 0.320018716764294 no 2254 0.318567424259067 3350 1258686 SGTC_2594 a-mangostin 100 µM -0.472360067064775 0.319793394832251 no 2255 0.318334901250025 3351 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_171 k064-0041 9.68 µM -0.47282894584289 0.319631283255595 no 2256 0.318167610562667 3226 53325 SGTC_1947 st076332 61.6 µM -0.473286515694478 0.319473114880323 no 2257 0.318004390526466 3338 24208416 SGTC_1330 1469-0054 61.8 µM -0.475905910895188 0.318568300148491 no 2258 0.317070705460261 3343 7102664 SGTC_269 exalamide 29 µM -0.47604511190912 0.318520246298969 no 2259 0.317021119677523 3244 3316 A derivative of salicylamide. SGTC_1703 st026983 48.3 µM -0.476092098454433 0.31850402667241 no 2260 0.317004383007881 3362 1104023 SGTC_670 4204-0025 119 µM -0.476524555575831 0.318354759996327 no 2261 0.316850358792967 3325 719039 SGTC_1253 0550-0034 176 µM -0.477885574484057 0.317885183922637 no 2262 0.316365824617912 3331 5969915 SGTC_34 0469-0683 81.75 µM -0.478631896970746 0.317627813405894 no 2263 0.316100261237185 3306 3690923 SGTC_2401 5128683 200 µM -0.479633089458712 0.317282688952776 no 2264 0.315744156633564 3241 708373 SGTC_370 0180-0345 38.7 µM -0.479720843982686 0.317252446359871 no 2265 0.315712952209346 3177 3989527 SGTC_489 paxilline 115 µM -0.481064112000509 0.316789672103491 no 2266 0.315235466760598 3303 105008 A toxic potassium channel blocker. SGTC_1234 0326-0494 15.5 µM -0.481188138313727 0.316746957776641 no 2267 0.315191395228709 3396 1547813 SGTC_2640 pentamidine 10.38 µM -0.481925795045843 0.316492961284101 no 2268 0.314929330513713 3328 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_683 panaxydol 45 µM -0.482680739158567 0.316233101833111 no 2269 0.314661220618971 3303 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1716 st033144 30.6155 µM -0.483925351200111 0.315804891831558 no 2270 0.314219423995758 3411 674617 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.484271968183175 0.315685681881522 no 2271 0.314096433623017 3274 688761 SGTC_771 0250-0039 27.3 µM -0.485410538344359 0.315294235094207 no 2272 0.313692579223957 3242 3005115 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.486515566676419 0.31491451834569 no 2273 0.313300835587496 3334 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1494 4358-1428 177 µM -0.486586173785964 0.314890262531907 no 2274 0.313275811810989 3382 1564571 SGTC_1689 st020265 53.493 µM -0.486656542581209 0.314866089381155 no 2275 0.313250873350518 3368 5758320 YPR016C TIF6 SGTC_2896 9052656 71.43 µM -0.487134718253922 0.314701847062642 no 2276 0.313081432150654 3317 6469436 SGTC_2184 6075246 200 µM -0.487554159614851 0.314557808799929 no 2277 0.312932835901162 3311 2267320 SGTC_1423 4048-0112 5.59 µM -0.487704132700241 0.314506314139459 no 2278 0.312879712038343 3342 X1423 SGTC_565 1418-0001 44.5 µM -0.488451674859222 0.314249692388835 no 2279 0.312614973647866 3389 2862145 SGTC_2868 9035608 32.47 µM -0.488740575821929 0.314150540390181 no 2280 0.312512686675542 3278 6462614 SGTC_2133 5320837 200 µM -0.488845357170768 0.314114582314204 no 2281 0.31247559183202 3373 2841355 SGTC_219 mitoxanthrone 164.414 µM -0.489234757055298 0.313980966453341 no 2282 0.312337752579463 3306 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3083 9117465 49.47 µM -0.492970056421364 0.312700503732854 no 2283 0.311016872547113 3328 16420915 SGTC_1443 4112-3303 14 µM -0.493350868046697 0.312570087827216 no 2284 0.310882345849767 3296 704433 SGTC_1901 st060216 58.6 µM -0.493748472304608 0.312433946018812 no 2285 0.310741913902955 3246 688792 SGTC_2756 carbadox 75.1 µM -0.493846274233654 0.312400462041061 no 2286 0.310707374947011 3279 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1832 st054113 55 µM -0.494489406597494 0.312180314489275 no 2287 0.310480292970309 3365 1251267 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.494830676458774 0.31206352326478 no 2288 0.310359824178392 3285 6708630 An antioxidant. SGTC_2692 st077426 47.7 µM -0.495753124075764 0.311747932786949 no 2289 0.310034300567163 3398 25238571 SGTC_492 tmb-8 126 µM -0.496742892562222 0.311409463985383 no 2290 0.309685185540614 3290 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2249 haloperidol 116.36 µM -0.497070490304272 0.311297471239589 no 2291 0.309569671764913 3339 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2199 6590217 200 µM -0.498153694203568 0.310927290933837 no 2292 0.309187858736344 3292 703109 SGTC_1631 benzylvanillin 81.9 µM -0.498834518285188 0.310694720062956 no 2293 0.308947983913817 3363 75506 SGTC_917 harmaline 728.087 nM -0.498914139606745 0.310667526197546 no 2294 0.308919936243208 3306 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1355 1499-0035 1.68 µM -0.499269334128785 0.310546225665614 no 2295 0.308794827817028 3285 1548538 SGTC_1232 0279-0259 161 µM -0.50110693418187 0.309919006106707 no 2296 0.3081479334879 3309 1560000 SGTC_1334 1486-0610 236 µM -0.501438079107362 0.309806036672007 no 2297 0.308031423090006 3364 3742339 SGTC_325 2810-4341 181 µM -0.501746100863335 0.309700971782298 no 2298 0.307923065739266 3381 774970 SGTC_2475 5812728 15.03 µM -0.502598797552179 0.309410201732464 no 2299 0.307623187428266 3295 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2699 st077704 54.6 µM -0.50304999196528 0.309256392431719 no 2300 0.307464562322584 3341 645852 SGTC_1819 st053448 58.6 µM -0.506738640005282 0.308000211197494 no 2301 0.306169107412573 3260 2857616 SGTC_1031 k035-0009 16 µM -0.507819320992142 0.307632606521427 no 2302 0.305790029365275 3412 5180959 SGTC_1075 aripiprazole 15.2 µM -0.507915303791194 0.307599966321998 no 2303 0.305756370857285 3308 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1804 st050076 49.1 µM -0.508908540893982 0.307262292590703 no 2304 0.305408166512647 3382 3895976 SGTC_2800 7887935 81.82 µM -0.509308406112954 0.307126395338836 no 2305 0.305268033329202 3388 2961002 SGTC_391 gliotoxin 8.33 µM -0.509923304341128 0.30691746916213 no 2306 0.305052597289352 3443 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_335 4077-0256 27.6 µM -0.510506728835693 0.306719294885781 no 2307 0.304848250843549 3349 3121989 SGTC_1179 1021-1431 9.29 µM -0.511168575013559 0.306494551166834 no 2308 0.304616510608184 3341 2840958 SGTC_262 fenpropimorph 62.5 µM -0.511911048644342 0.306242515303265 no 2309 0.304356632601396 3344 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2969 9091408 28.7 µM -0.51236488580953 0.306088503458174 no 2310 0.304197830738719 3245 4286311 SGTC_2887 9044784 58.44 µM -0.513130260974893 0.305828847319499 no 2311 0.303930102471555 3343 6465546 SGTC_1876 myriocin 605 nM -0.515314126216745 0.305088500312386 no 2312 0.303166764624571 3444 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2928 9011484 9.79 µM -0.516637774990862 0.304640160936039 no 2313 0.302704520459461 3383 2994751 SGTC_663 1486-0733 13.9 µM -0.52105911234718 0.303144717555045 no 2314 0.301162796510894 3315 722445 YPR165W RHO1 SGTC_3084 9116877 49.47 µM -0.522527969790461 0.302648628645797 no 2315 0.300651388728935 3351 27241325 SGTC_1668 st014914 51.6 µM -0.522949170579191 0.30250644029153 no 2316 0.30050481283995 3417 2839556 SGTC_108 0509-0257 621.132 µM -0.52323724559166 0.302409209593596 no 2317 0.300404582682262 3337 536624 SGTC_2390 9097792 176.6 µM -0.523919944936447 0.302178841796142 no 2318 0.300167110914299 3329 4497149 SGTC_1025 k007-0731 70 µM -0.524230397832004 0.302074109663585 no 2319 0.30005915032399 3278 6256118 SGTC_235 0330-0087 5 mM -0.524434785001879 0.302005167992236 no 2320 0.299988083883644 3372 46494818 YHR062C RPP1 SGTC_384 k007-0144 5.16 µM -0.527493859781868 0.300974159577289 no 2321 0.298925339651131 3362 6824886 SGTC_146 3448-8650 53.125 µM -0.528314422267846 0.300697873295384 no 2322 0.298640561597096 3331 2891488 YIL048W NEO1 SGTC_1513 0337-0559 19 µM -0.528975126640308 0.300475495026556 no 2323 0.298411352356251 3287 775073 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.529045253973315 0.300451896100798 no 2324 0.298387028728619 3391 97141 SGTC_1817 st052116 64.4 µM -0.529315601437016 0.300360927858892 no 2325 0.298293267302473 3428 4361398 SGTC_1753 st043925 64 µM -0.531076082690342 0.299768854535216 no 2326 0.297683028690084 3395 670181 SGTC_2108 5365811 200 µM -0.531267571593689 0.299704486145839 no 2327 0.297616686929518 3409 780283 SGTC_990 3985-0011 41.3 µM -0.531284840937796 0.2996986814182 no 2328 0.297610704258206 3336 5399565 YGL099W LSG1 SGTC_2684 capsaicin 100 µM -0.532090146631206 0.299428051386202 no 2329 0.297331780744284 3437 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_976 1348-1067 47.6 µM -0.532593609166564 0.299258914702969 no 2330 0.297157463510359 3384 5310671 YGL099W LSG1 SGTC_159 3970-0959 50 µM -0.532619114310496 0.299250347482337 no 2331 0.297148633935615 3497 6615653 SGTC_13 0199-0087 65 µM -0.532775488529315 0.299197823552715 no 2332 0.297094501679916 3426 4589825 SGTC_1380 2291-0730 164 µM -0.532972627474941 0.299131613279388 no 2333 0.29702626427507 3352 2999191 SGTC_186 3455-3465 67.277 µM -0.533907080786573 0.298817862159381 no 2334 0.296702911449389 3376 755278 SGTC_3342 9147791 14.508 µM -0.535346228964991 0.298334947930111 no 2335 0.296205232469791 3388 1838168 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.538368540065624 0.297321952798815 no 2336 0.295161320595741 3424 229346 A bile salt which induces apoptosis. SGTC_164 4100-3994 89.624 µM -0.539546597691405 0.296927526558415 no 2337 0.294754876628884 3489 4615967 SGTC_657 3534-0529 86.7 µM -0.540241284986176 0.296695050121651 no 2338 0.294515322229747 3434 1049549 SGTC_863 0466-0191 129 µM -0.540316281845855 0.296669957480038 no 2339 0.294489465856277 3421 765160 YPR165W RHO1 SGTC_2265 7929201 200 µM -0.540743328576264 0.29652709361663 no 2340 0.294342254600037 3293 1265108 SGTC_1411 3909-8223 150 µM -0.541130386888269 0.296397634685739 no 2341 0.294208857488708 3441 X1411 SGTC_2649 anisomycin 9.56 µM -0.541277624283199 0.296348395173684 no 2342 0.294158120419374 3418 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_432 NS 1619 61.3 µM -0.541283165965027 0.29634654198329 no 2343 0.294156210870032 3445 4552 A K+/calcium channel activator. SGTC_2437 5741531 144.16 µM -0.544558125559228 0.295252295476599 no 2344 0.293028730627264 3489 2262990 SGTC_101 0490-5701 117.494 µM -0.544558942942177 0.295252022600646 no 2345 0.293028449474778 3408 4661669 SGTC_1608 st001473 40.5 µM -0.545345164660612 0.294989603317905 no 2346 0.292758073384862 3331 7292267 SGTC_1260 0700-1617 7.75 µM -0.545961079501112 0.294784102900813 no 2347 0.292546345582429 3418 2853078 SGTC_147 4466-0538 29.23 µM -0.547224222472949 0.294362860984541 no 2348 0.292112348429828 3523 6742687 YHR072W ERG7 SGTC_2150 5556613 200 µM -0.547563371742836 0.294249806419893 no 2349 0.291995872829305 3376 743190 SGTC_2765 myclobutanil 7.74 µM -0.548256791008593 0.294018719282602 no 2350 0.29175779597436 3448 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_835 0312-0010 67.2 µM -0.55025768492558 0.293352377270807 no 2351 0.291071321589568 3383 1626196 SGTC_768 0384-0033 77.3 µM -0.550269855435426 0.293348326363345 no 2352 0.291067148393613 3339 3965305 YMR134W ERG29 SGTC_842 0271-0008 11.1 µM -0.550717472873901 0.293199356630116 no 2353 0.290913682437297 3489 1221709 SGTC_2010 4012422 159 µM -0.550927268966813 0.293129547322669 no 2354 0.290841766715974 3370 952393 SGTC_533 1222-0222 6.71 µM -0.551972052543885 0.292782012122604 no 2355 0.290483750561131 3493 3982874 SGTC_2978 9011784 42.97 µM -0.554648939933167 0.291892450616443 no 2356 0.289567403680504 3405 2994934 SGTC_3181 9108277 49.47 µM -0.556030608061696 0.29143379896526 no 2357 0.289094965399383 3360 17097298 SGTC_984 1492-0255 2.91 µM -0.556091796962462 0.291413494779939 no 2358 0.289074051264318 3410 1585198 SGTC_2292 7671323 168.05 µM -0.556106809360882 0.291408513347907 no 2359 0.289068920191979 3462 937504 SGTC_1686 st019653 115.5 µM -0.556318776060713 0.291338182544465 no 2360 0.288996476882615 3467 97252 SGTC_2453 5731132 22.18 µM -0.557567746715784 0.29092393352826 no 2361 0.288569792948133 3489 1362040 SGTC_739 1486-1183 203 µM -0.558382434594531 0.290653872517516 no 2362 0.28829163241179 3471 4346692 SGTC_1133 3473-0247 50 µM -0.558544387247536 0.290600200783665 no 2363 0.288236351658704 3354 711311 SGTC_270 tamoxifen 5.46 µM -0.559248894755627 0.290366778253468 no 2364 0.287995933986042 3555 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_214 4373-3496 70 µM -0.559280378016667 0.290356349041001 no 2365 0.287985192332814 3528 3779166 SGTC_376 3970-0862 59.1 µM -0.559628992792599 0.290240877889875 no 2366 0.287866262436908 3439 3135186 SGTC_180 1486-1293 102.781 µM -0.561314457924126 0.289682907435077 no 2367 0.287291593590678 3530 4140536 SGTC_2327 6189656 200 µM -0.561591839156542 0.289591129101185 no 2368 0.287197070939964 3453 5349088 SGTC_1870 st057514 26.5 µM -0.561973146081971 0.289464986708164 no 2369 0.287067157769535 3381 5393161 SGTC_111 0083-0039 52.457 µM -0.562239348120114 0.289376938142392 no 2370 0.286976477906917 3406 759313 SGTC_38 0929-0051 58.268 µM -0.562279761324598 0.289363572234935 no 2371 0.286962712617849 3424 1379719 SGTC_2940 9060638 45.86 µM -0.563080363205983 0.289098848028536 no 2372 0.286690081185374 3430 4027022 SGTC_2221 6807166 181.081 µM -0.565120238220427 0.288424865419745 no 2373 0.285995991909733 3427 674925 SGTC_1556 plumbagin 1.48 µM -0.566346337647527 0.288020114122378 no 2374 0.285579183127993 3448 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1221 2958-7315 257 µM -0.56654255928707 0.287955363713335 no 2375 0.285512505022641 3463 4562705 SGTC_3260 9137109 49.47 µM -0.566691189766075 0.287906322299526 no 2376 0.285462003810242 3382 17478346 SGTC_374 0880-0231 82.3 µM -0.567001297259564 0.287804013390179 no 2377 0.285356650124772 3446 6833587 SGTC_2073 5212005 126 µM -0.567112733588028 0.28776725314218 no 2378 0.285318796073098 3371 691789 SGTC_1447 4239-0816 81.9 µM -0.568589703343848 0.287280244893117 no 2379 0.284817307055722 3398 1341554 SGTC_72 0744-0168 198.391 µM -0.570379411410659 0.286690639123455 no 2380 0.284210195327467 3308 677577 SGTC_3111 9122088 49.47 µM -0.570650049404322 0.286601529452996 no 2381 0.284118442340026 3376 16876704 SGTC_3304 9125678 46.087 µM -0.571888183767548 0.28619403166877 no 2382 0.283698864861322 3428 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2248 tofa 1.1 µM -0.572395707433298 0.286027073804937 no 2383 0.283526961649155 3404 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1028 k015-0029 4.8 µM -0.572740428513807 0.285913698805293 no 2384 0.283410229732511 3475 4588309 SGTC_1000 4048-0884 8.67 µM -0.573312470581532 0.285725607570672 no 2385 0.283216571612715 3484 13040088 SGTC_1555 citronellol 128 µM -0.573357671311897 0.285710747779698 no 2386 0.28320127214313 3465 8842 A terpine precursor. SGTC_1971 st069429 63.5 µM -0.575417596185341 0.285033935632354 no 2387 0.282504453233254 3478 1246522 YGL099W LSG1 SGTC_24 0417-1663 219 µM -0.575881376386099 0.284881660779789 no 2388 0.282347682250786 3476 4329390 SGTC_132 0417-1715 25.805 µM -0.577501810338076 0.284349921964327 no 2389 0.281800258020035 3545 6769098 SGTC_2227 7312221 64.1025 µM -0.579442545056933 0.283713702654622 no 2390 0.28114530190489 3483 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1951 sophoraflavanone G 9.2 µM -0.58078324656127 0.283274587127779 no 2391 0.280693273871889 3422 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_558 k064-0027 21.3 µM -0.580826987664392 0.283260266241589 no 2392 0.2806785321395 3468 5088526 SGTC_816 0325-0417 81.3 µM -0.581491135231617 0.283042866258913 no 2393 0.28045474554562 3481 68101 SGTC_746 1095-0025 46.6 µM -0.583882825350004 0.282260642097283 no 2394 0.279649574440009 3526 6749286 SGTC_2935 9038016 29.96 µM -0.584190342297441 0.28216014139053 no 2395 0.279546129209593 3508 6463195 SGTC_2269 7935389 174.42 µM -0.58624772554454 0.281488204166309 no 2396 0.278854527048962 3462 97605 SGTC_440 fluspirilene 35.1 µM -0.587174305250061 0.28118583743841 no 2397 0.278543323683662 3590 3396 An atypical antipsychotic. SGTC_1772 st048439 82.2 µM -0.589613631682535 0.280390573489745 no 2398 0.277724855273274 3473 2927068 YDL195W SEC31 SGTC_2902 5787006 60.46 µM -0.589616363548465 0.280389683463546 no 2399 0.277723939307783 3441 591003 SGTC_2645 abamectin 100 µM -0.589803269448093 0.280328793845526 no 2400 0.277661275258178 3492 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_88 0180-0332 8.668 µM -0.590543063681137 0.280087848853739 no 2401 0.277413311809053 3507 3101745 SGTC_625 k213-0058 121 µM -0.592217868552921 0.279542749580439 no 2402 0.276852352760313 3542 3655420 SGTC_793 0488-0545 106 µM -0.592768679226862 0.27936358967642 no 2403 0.276667985736694 3396 292548 SGTC_1995 st072814 61.1 µM -0.593752337096077 0.279043778187286 no 2404 0.276338886094704 3411 5769371 SGTC_2653 dihydrofissinolide 100 µM -0.593835391131292 0.279016783420692 no 2405 0.276311107734359 3511 6857746 SGTC_2103 5378138 10 µM -0.594166248955457 0.27890925845276 no 2406 0.27620046219799 3563 244142 SGTC_2994 9053520 71.4286 µM -0.594216859872324 0.278892812267837 no 2407 0.276183538803289 3487 4647384 SGTC_1111 tnp00062 510.699 nM -0.595144834139832 0.278591347626716 no 2408 0.27587333088025 3551 676306 SGTC_2959 9079155 11 µM -0.595966841699837 0.278324440285912 no 2409 0.275598689091366 3525 16189457 SGTC_428 3448-4153 16.5 µM -0.597048441244577 0.277973432975465 no 2410 0.275237519714388 3438 3834874 SGTC_1046 2001-0062 216 µM -0.597277866491455 0.277899006268874 no 2411 0.275160939648687 3464 739778 SGTC_1916 st067606 49.2 µM -0.597454573564384 0.277841688235491 no 2412 0.275101963584375 3478 19590279 SGTC_899 1083-0020 478 µM -0.598381788793326 0.277541024371693 no 2413 0.27479260716138 3566 767123 SGTC_2379 9035213 200 µM -0.599100401703602 0.277308112448606 no 2414 0.274552966910573 3529 646551 SGTC_1854 st056233 32.9 µM -0.600231856866955 0.276941586750795 no 2415 0.274175862712105 3489 5393174 SGTC_156 3474-0145 5.642 µM -0.601513854150561 0.2765265809961 no 2416 0.273748893525801 3500 2265471 SGTC_149 3970-0822 46.1 µM -0.604944724973914 0.275417448021464 no 2417 0.272607862251301 3572 3114250 YBL034C STU1 SGTC_2616 abietic acid 100 µM -0.60605855524114 0.2750578398427 no 2418 0.272237935372407 3548 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_70 0141-0289 43.283 µM -0.606381732537734 0.274953543013032 no 2419 0.272130647983551 3502 352408 SGTC_2674 ligustilide 100 µM -0.606754972490262 0.274833114052647 no 2420 0.272006767111177 3504 5319022 A signalling regulator. SGTC_1856 st057054 55.7 µM -0.607629676969955 0.274550985316128 no 2421 0.271716556681657 3616 1266018 SGTC_1289 0976-0073 69.1 µM -0.607830287308939 0.274486300249629 no 2422 0.27165001969292 3553 3391136 SGTC_1158 4092-0494 91.8 µM -0.608685103484067 0.274210756499521 no 2423 0.271366591392791 3579 1148199 SGTC_1652 st011932 78 µM -0.610523319626007 0.273618684095435 no 2424 0.27075760031122 3511 1551076 SGTC_1137 ixabepilone 100 µM -0.611103270725603 0.273432018567819 no 2425 0.270565607331736 3556 154225 A novel microtubule stabilizer. SGTC_1271 0832-2808 169 µM -0.613888926712812 0.272536295163803 no 2426 0.269644364007646 3573 3663794 SGTC_1548 st061468 90.8 µM -0.614932028175999 0.272201262781089 no 2427 0.2692998051065 3513 390799 SGTC_2520 obtusaquinone 4.71 µM -0.616870853244959 0.271579078446926 no 2428 0.268659956554227 3609 5967872 SGTC_1026 k007-1105 30.6 µM -0.617260115872284 0.271454246404372 no 2429 0.268531584745738 3546 7066794 SGTC_3302 9125395 16.351 µM -0.617307811960941 0.271438952783938 no 2430 0.268515857554875 3471 17599668 SGTC_356 1634-0012 32.5 µM -0.618519482724805 0.271050577891714 no 2431 0.268116479579995 3550 735457 SGTC_2701 st077767 14.721 µM -0.618573306519454 0.271033332268617 no 2432 0.268098745693604 3531 5721188 SGTC_2328 6201408 200 µM -0.618882346500478 0.270934323701207 no 2433 0.267996934499515 3521 2890418 SGTC_1138 3761-0006 1.03 µM -0.620199402158434 0.2705125749389 no 2434 0.267563257534466 3548 12061087 SGTC_255 tunicamycin 200.472 nM -0.620729645056052 0.270342872733603 no 2435 0.26738876036058 3503 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1457 k015-0032 57.3 µM -0.621431280625506 0.27011839879208 no 2436 0.267157947992531 3555 4302660 SGTC_2152 5568786 200 µM -0.623872419156951 0.269338133700467 no 2437 0.266355687408865 3536 5399883 SGTC_2623 humulene 100 µM -0.624214001684297 0.269229043323493 no 2438 0.266243526355963 3514 6187145 An anti-inflammatory. SGTC_188 3229-0966 278.469 µM -0.624488802927177 0.269141296812345 no 2439 0.266153310769481 3611 5722370 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.62470751857298 0.269071469193663 no 2440 0.266081518808945 3569 4213774 SGTC_1145 3546-0597 10.2 µM -0.627612535963496 0.26814487041122 no 2441 0.265128897250919 3511 875334 SGTC_2030 5175110 200 µM -0.628274132086364 0.267934069158858 no 2442 0.264912187192493 3608 2831986 SGTC_950 1165-0508 94.1 µM -0.628585493088352 0.267834890559525 no 2443 0.264810230058827 3530 6148369 SGTC_775 4577-0580 57.3 µM -0.629291726759385 0.267610000748422 no 2444 0.264579043331305 3635 2006902 SGTC_2708 st078559 56 µM -0.630016213964809 0.267379397317792 no 2445 0.264341988020191 3512 17250902 SGTC_3212 9128307 49.47 µM -0.631548242562677 0.266892084742163 no 2446 0.263841058047971 3426 27243542 SGTC_1057 3448-5381 134 µM -0.632683397171427 0.266531300738743 no 2447 0.263470207046188 3577 5497911 SGTC_1846 st056244 14.8 µM -0.634347144498057 0.266002961187143 no 2448 0.262927147833426 3529 5393182 SGTC_2127 5253358 187.912 µM -0.634874482294914 0.265835610606911 no 2449 0.262755140460526 3521 20612 SGTC_2545 solidagenone 89.61 µM -0.635749377140319 0.265558080594552 no 2450 0.262469893730195 3423 6708572 An anti ulcer agent SGTC_1227 3909-8010 46.6 µM -0.636544693551181 0.2653059216627 no 2451 0.2622107300162 3548 15982272 SGTC_2967 9089538 49.85 µM -0.636552279101654 0.265303517212354 no 2452 0.262208258801866 3585 728216 SGTC_1796 st049173 110.4 µM -0.638187416371437 0.264785473484959 no 2453 0.261675843793519 3552 94134 SGTC_618 k072-0232 33.2 µM -0.638846693487579 0.264576747074053 no 2454 0.261461334428421 3546 5872756 YGL099W LSG1 SGTC_273 hydroxyurea 18.1 mM -0.64437966020267 0.262828321208708 no 2455 0.259664635360516 3628 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1437 4092-1038 11.6 µM -0.644790072855153 0.262698865986806 no 2456 0.25953161798527 3584 3977136 SGTC_1022 4477-0945 21.3 µM -0.645759303149604 0.262393274142795 no 2457 0.259217623953669 3575 4648966 SGTC_1896 st058441 89 µM -0.646356764365818 0.26220498933861 no 2458 0.259024166939608 3530 688759 SGTC_3153 9100258 49.47 µM -0.648333294075639 0.261582596532281 no 2459 0.258384702193032 3531 25236848 SGTC_3105 9121040 49.47 µM -0.648887946426126 0.261408077465324 no 2460 0.258205403137516 3472 41448907 SGTC_970 1315-0089 19.5 µM -0.650109340903913 0.261023981672147 no 2461 0.257810797971074 3557 6811083 YLR033W RSC58 SGTC_2656 pseudo-anisatin 100 µM -0.650195317763994 0.26099695519194 no 2462 0.257783032571326 3605 6708809 A neurotoxin. SGTC_2713 st079149 53.4 µM -0.651519913105267 0.260580755891963 no 2463 0.257355463478554 3600 3103253 SGTC_2311 7694451 200 µM -0.651755714454948 0.260506700912674 no 2464 0.257279387294709 3536 2163142 SGTC_2012 4023501 200 µM -0.652052030683283 0.260413656201817 no 2465 0.257183803876226 3552 3477460 SGTC_1680 diphenhydramine 100 µM -0.652942222765821 0.260134234624311 no 2466 0.256896763623261 3577 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2790 5423970 71.43 µM -0.653077912097007 0.260091656802656 no 2467 0.256853025577513 3621 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2380 9035439 200 µM -0.653849555789251 0.259849591818464 no 2468 0.256604367957127 3668 6462575 SGTC_1346 1488-2224 62.4 µM -0.654203029978493 0.259738745629484 no 2469 0.25649050487009 3608 3722427 SGTC_2155 5570423 76 µM -0.655275103346844 0.259402702786598 no 2470 0.256145323635538 3558 797402 SGTC_667 1498-1044 59 µM -0.657571059515012 0.258683788507964 no 2471 0.255406898016729 3626 6739982 SGTC_3351 9150312 21.596 µM -0.657661462157937 0.258655502575964 no 2472 0.255377845491799 3585 4904905 SGTC_1431 4049-0260 9.09 µM -0.657661490327713 0.25865549376222 no 2473 0.255377836439201 3594 3854841 SGTC_1514 1189-1591 158 µM -0.658023167390865 0.258542345251741 no 2474 0.255261622252941 3631 767698 YMR146C TIF34 SGTC_3028 9087778 49.47 µM -0.659232946836351 0.258164059328114 no 2475 0.254873096553138 3561 17217395 SGTC_2406 ethylparaben 405.7 µM -0.659684504524459 0.258022935338311 no 2476 0.254728156288265 3458 8434 A possible steroid mimic. SGTC_2211 7117706 200 µM -0.659840595929507 0.257974161860528 no 2477 0.254678064358112 3573 822771 SGTC_435 c-PAF 6.7 µM -0.659953701176727 0.25793882314486 no 2478 0.254641770514852 3564 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1017 4239-0030 168 µM -0.660803622769826 0.257673353162572 no 2479 0.254369129609848 3568 1149593 SGTC_2585 alliin 100 µM -0.661085845645566 0.25758523323532 no 2480 0.254278630990716 3687 87310 A garlic compound which reacts with lipids. SGTC_2161 5662504 8.5105 µM -0.662775673194999 0.257057937097662 no 2481 0.253737118032831 3581 2859334 SGTC_1141 3253-0389 52.6 µM -0.662989595800089 0.256991224448063 no 2482 0.253668608762917 3597 5402031 SGTC_1214 0358-0031 63.7 µM -0.663454010920015 0.256846425678303 no 2483 0.253519912058765 3662 4301366 SGTC_1390 3413-2614 145 µM -0.66351173641074 0.256828430566506 no 2484 0.253501432677928 3630 3421432 SGTC_546 peri-Naphthalide 147 µM -0.663902564623631 0.256706612617624 no 2485 0.253376337360939 3560 223824 A penicillin ester. SGTC_385 1494-0393 12.4 µM -0.664076130720486 0.25665252313657 no 2486 0.253320793164964 3625 3090647 SGTC_1181 1222-0449 220 µM -0.665726847430655 0.256138396806061 no 2487 0.25279285495475 3676 658318 SGTC_2711 st079103 59.1 µM -0.66580218430584 0.256114945473952 no 2488 0.252768774271443 3610 54693780 SGTC_199 4063-0024 41.6 µM -0.666147541198593 0.256007454962027 no 2489 0.252658399834323 3643 306215 SGTC_2065 5221596 34.26 µM -0.66660864478413 0.255863975599542 no 2490 0.252511072880048 3612 788581 SGTC_2416 tofa 880 nM -0.667299865400272 0.255648970475422 no 2491 0.252290306175108 3541 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1388 3346-4487 254 µM -0.667788253511527 0.255497113584324 no 2492 0.252134382858632 3663 3345614 SGTC_46 0329-0187a 2.197 µM -0.668361164847423 0.255319035561534 no 2493 0.251951539372696 3616 46494817 SGTC_1285 0929-0069 65.5 µM -0.668688404023482 0.255217348933037 no 2494 0.251847133064243 3621 1206237 SGTC_1578 josamycin 24.2 µM -0.66978397272572 0.254877065004261 no 2495 0.251497755993295 3566 5282165 A P450 substrate. SGTC_1113 artemisinin 1.17947 µM -0.669851139939066 0.254856210578111 no 2496 0.251476344691173 3634 2240 An anti-malaria and mitochondrial poison. SGTC_738 1315-0003 72.4 µM -0.67056870502415 0.25463347298369 no 2497 0.251247662223034 3633 6251474 SGTC_626 0214-0009 33 µM -0.671934037078113 0.25420994537808 no 2498 0.250812845261887 3659 3437874 SGTC_1872 amphotericin b 148 nM -0.672198421139681 0.254127975843358 no 2499 0.250728693001499 3631 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2651 TUB2.036 5 µM -0.673387030829334 0.253759631074568 no 2500 0.250350548658104 3731 15992207 YFL037W TUB2 SGTC_971 1315-0384 26.7 µM -0.677197090698262 0.252580802839935 no 2501 0.249140456698076 3639 6769120 SGTC_2151 5563267 85.4165 µM -0.678490255774682 0.252181355763152 no 2502 0.248730450020476 3644 5310824 SGTC_902 1120-0002 2.07 µM -0.678849448224112 0.252070463593337 no 2503 0.248616629435167 3635 3280475 SGTC_1029 k015-0030 64.7 µM -0.679209276557077 0.251959400908674 no 2504 0.248502635175738 3668 2208316 SGTC_3252 9135871 49.47 µM -0.680742973115603 0.251486308110242 no 2505 0.248017069865309 3668 17682838 SGTC_3292 9120825 59.784 µM -0.681069824159409 0.251385546483159 no 2506 0.24791365494526 3662 24824900 SGTC_953 1188-0045 9.7 µM -0.683114683293901 0.250755642075085 no 2507 0.247267188926131 3630 6144426 SGTC_2001 4023502 57.655 µM -0.683359664561146 0.250680233428106 no 2508 0.247189800541889 3641 108941 YCR052W RSC6 SGTC_1850 st056238 17 µM -0.686459616968808 0.249727063358618 no 2509 0.24621166066403 3664 5393177 SGTC_2177 5811945 192 µM -0.686462003863009 0.249726330181182 no 2510 0.246210908318615 3676 5343475 SGTC_1496 4469-0713 57.4 µM -0.68668619226476 0.249657471781932 no 2511 0.246140249971666 3631 746691 SGTC_2496 diffractaic acid 79.83 µM -0.687108217403071 0.249527876136722 no 2512 0.246007268147352 3706 94870 An apoptosis inducer which activates caspases. SGTC_2879 9041815 71.43 µM -0.688783878850118 0.249013666274357 no 2513 0.245479641048155 3614 4942971 SGTC_1988 st071872 53.4 µM -0.689106929511464 0.248914596656809 no 2514 0.245377989808356 3667 16414116 SGTC_1177 0983-0204 23.6 µM -0.689188336413145 0.248889634994744 no 2515 0.245352377851855 3685 766818 SGTC_1119 parthenolide 318.541 nM -0.690385625568007 0.248522666177848 no 2516 0.244975856921126 3750 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.690423804988349 0.248510968940311 no 2517 0.244963855455627 3670 115019 SGTC_896 0964-0007 44.5 µM -0.690465431294215 0.248498215995913 no 2518 0.24495077084339 3643 6756758 SGTC_684 1140-0066 328 µM -0.691200468295595 0.248273082055158 no 2519 0.244719784817959 3673 6813534 SGTC_143 4032-1194 15.74 µM -0.691280977566434 0.248248429539856 no 2520 0.244694491836574 3669 1806963 SGTC_1306 1185-0270 9.02 µM -0.693854146471703 0.247461194793223 no 2521 0.243886840973767 3665 1548076 SGTC_2506 ethyl hematommate 54.16 µM -0.693993763386586 0.247418518612573 no 2522 0.243843060032643 3683 3940691 An allergen. SGTC_1235 benzylparaben 21.5 µM -0.694615544657101 0.247228508829468 no 2523 0.243648133962749 3643 7180 SGTC_179 1273-0063 6.77 µM -0.695606389822876 0.246925878337228 no 2524 0.243337681714714 3651 3108139 SGTC_1653 st012112 65 µM -0.695647849751705 0.246913219693895 no 2525 0.24332469612431 3673 720429 SGTC_2241 6772625 37.8075 µM -0.695987930549535 0.246809398531578 no 2526 0.243218194160316 3609 2285411 SGTC_3025 9087895 49.47 µM -0.696207608936954 0.246742346701775 no 2527 0.243149411614745 3678 17173641 SGTC_1098 clofazimine 15.1 µM -0.697311465845848 0.246405567187915 no 2528 0.242803947034309 3715 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1563 conessine 56.1 µM -0.697700123717297 0.246287048882358 no 2529 0.242682375391048 3743 441082 An anti-amoebic, histamine inhibitor. SGTC_2691 st077356 60.2 µM -0.697877161389547 0.246233072703559 no 2530 0.242627009178894 3710 2839272 SGTC_2277 7947813 106.88 µM -0.69840461276527 0.246072298153275 no 2531 0.242462096223089 3722 1246798 SGTC_1762 st045503 25.4615 µM -0.699297088123029 0.245800387493487 no 2532 0.24218319321025 3711 4645554 SGTC_3343 9148379 18.9835 µM -0.700648575506445 0.245388936792436 no 2533 0.241761177949724 3698 1955036 SGTC_1704 st028805 70.8 µM -0.701062102815344 0.245263115345887 no 2534 0.241632129757784 3685 2876101 SGTC_766 1391-0721 126 µM -0.701557521326743 0.245112423037273 no 2535 0.241477575283544 3667 1020919 YIL115C NUP159 SGTC_2929 9013348 24.6 µM -0.701836722932215 0.245027519744753 no 2536 0.241390497118796 3702 2995952 SGTC_3013 9080133 71.4286 µM -0.702297245381646 0.244887512603355 no 2537 0.241246905392042 3742 17050193 SGTC_1402 3909-7673 35.9 µM -0.702407745053083 0.244853925113193 no 2538 0.241212458302846 3670 5328014 SGTC_2093 5331342 194.4 µM -0.702599096783165 0.244795767688656 no 2539 0.24115281277389 3686 33839 SGTC_1379 2144-0755 36.5 µM -0.702679969772698 0.244771190241673 no 2540 0.241127606568663 3712 5392327 SGTC_883 0850-0245 24.6 µM -0.7028213686585 0.244728222057748 no 2541 0.241083539309307 3735 6823229 YPR165W RHO1 SGTC_7 0192-1582 4.227 µM -0.703147253795712 0.2446292078017 no 2542 0.240981993200115 3716 252616 SGTC_699 0375-0592 111 µM -0.703391343530968 0.244555059720209 no 2543 0.240905949852774 3707 762578 SGTC_2000 st075254 36.4 µM -0.704527096642878 0.244210206880743 no 2544 0.240552290774806 3651 17234175 SGTC_2981 9013952 38.96 µM -0.704679058643228 0.244164086001624 no 2545 0.240504993191104 3598 2996344 SGTC_1270 0831-1170 17.3 µM -0.705234376605837 0.243995585443421 no 2546 0.240332195701454 3663 6764716 SGTC_2612 dictamnine 15.46 µM -0.705307665352762 0.2439733520691 no 2547 0.240309395601122 3648 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1643 st009866 20.2 µM -0.705404352446918 0.24394402208471 no 2548 0.24027931808717 3675 3156273 YOR207C RET1 SGTC_891 0929-0073 133 µM -0.705787420765943 0.243827837192783 no 2549 0.240160172991938 3717 5603632 SGTC_2749 bexarotene 57.39 µM -0.706883239038484 0.243495639714755 no 2550 0.239819520358906 3697 82146 An retinoic acid receptor inhibitor. SGTC_2395 5646831 180.19 µM -0.70702343345977 0.243453157401599 no 2551 0.239775957708582 3681 6808628 SGTC_1836 st055642 81 µM -0.708035386751975 0.243146629789379 no 2552 0.239461641281756 3695 8571 SGTC_2831 7999036 19.48 µM -0.708171948676332 0.243105280229891 no 2553 0.239419241880774 3692 2988270 SGTC_1736 st036774 51 µM -0.708372080760266 0.24304468914411 no 2554 0.239357112784964 3734 1272247 SGTC_2532 xanthone 78.9 µM -0.708906356547335 0.2428829742351 no 2555 0.239191295108432 3606 7020 An insecticide. SGTC_2788 5282734 71.43 µM -0.71146795431977 0.242108437701696 no 2556 0.238397151028183 3736 743706 SGTC_803 4488-1585 147 µM -0.71162843616067 0.242059958290333 no 2557 0.238347446708496 3659 747204 SGTC_2183 6420625 130.508 µM -0.712213706754837 0.241883200510383 no 2558 0.238166225225134 3707 2897619 SGTC_2955 9076254 12.21 µM -0.7135296424097 0.241486030179381 no 2559 0.237759038593262 3632 16459619 SGTC_260 nsc-65238 3.989 µM -0.714175499329245 0.241291229934642 no 2560 0.237559332509536 3633 3246252 SGTC_358 0075-0058 9.45 µM -0.716177035512822 0.240688078990428 no 2561 0.236941020564827 3687 1069125 SGTC_1888 azatryptophan 97.5 µM -0.71679455034098 0.240502160371408 no 2562 0.236750437412449 3680 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3133 9127736 49.47 µM -0.718269128225501 0.240058517530828 no 2563 0.236295680735269 3700 27243420 SGTC_832 4083-0019 164 µM -0.720338213699232 0.239436763585603 no 2564 0.235658390943862 3793 1990758 SGTC_410 α-linolenic acid 100 µM -0.720465764274338 0.239398463820391 no 2565 0.235619135705097 3778 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2324 6149169 200 µM -0.720609139016752 0.239355416507965 no 2566 0.235575014692918 3657 2888231 SGTC_201 4262-0159 12.803 µM -0.721140913290117 0.239195791748902 no 2567 0.235411410482386 3704 1341029 SGTC_1081 sertraline 6 µM -0.72133085777806 0.23913878947362 no 2568 0.235352987886811 3701 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1965 Pectolinarigenin 58.4 µM -0.721898394218633 0.238968516222983 no 2569 0.235178474302461 3714 5320438 An anti-inflammatory. SGTC_2220 6782180 200 µM -0.722483179074481 0.238793137439005 no 2570 0.23499873172436 3633 833803 SGTC_357 1325-0123 420 µM -0.72356273109956 0.238469561498341 no 2571 0.234667114359326 3688 1098503 SGTC_1294 1000-1494 117 µM -0.724065265300951 0.238319018000452 no 2572 0.234512833946389 3698 712797 YDL207W GLE1 SGTC_3308 9128332 17.569 µM -0.727253493404076 0.237365138534326 no 2573 0.233535340989351 3700 17332805 YDL196W YDL196W SGTC_1780 st038448 24.544 µM -0.728447153203386 0.237008549998845 no 2574 0.233169953750167 3763 728868 YDL195W SEC31 SGTC_980 1473-0395 201 µM -0.731256228698192 0.2361705423842 no 2575 0.232311330469126 3658 768876 SGTC_2983 9022671 12.99 µM -0.731477599556934 0.23610457214445 no 2576 0.232243741007807 3722 6405161 SGTC_1175 0741-0056 27.6 µM -0.73302257902571 0.235644439016773 no 2577 0.23177232911237 3784 765927 SGTC_2 0422-0095 29 µM -0.733457180195701 0.235515093223232 no 2578 0.231639817555596 3614 6790840 SGTC_602 3130-1533 38.1 µM -0.734441503275097 0.235222284345988 no 2579 0.231339849854473 3746 720941 SGTC_114 0364-0001 490.298 µM -0.734590035864656 0.235178117472432 no 2580 0.231294604086017 3766 4003655 SGTC_1987 st072290 61.9 µM -0.734634396235711 0.235164927592827 no 2581 0.231281092055476 3736 54697379 SGTC_464 bw-b 70c 158 µM -0.734711348801062 0.235142047890511 no 2582 0.231257653588758 3763 5353454 SGTC_3162 9099653 49.47 µM -0.735925435245733 0.23478123585103 no 2583 0.230888038543676 3690 25237511 SGTC_2181 6316240 54.2555 µM -0.737353834365412 0.234357124791041 no 2584 0.230453601060753 3737 12779990 SGTC_654 1124-0271 80.9 µM -0.738131982929482 0.234126260454914 no 2585 0.230217125085551 3726 5403748 SGTC_749 1000-0129 128 µM -0.738174568301656 0.234113629686106 no 2586 0.230204187493892 3771 708470 SGTC_168 3970-0862 530.542 µM -0.741330366108254 0.2331786747529 no 2587 0.22924657707336 3748 3135186 SGTC_2188 6126565 140.678 µM -0.741376684519676 0.233164967643435 no 2588 0.229232538644624 3694 874518 SGTC_2541 muurolladie-3-one 83.07 µM -0.743985712207807 0.232393594938307 no 2589 0.228442559491996 3760 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2919 7978188 46.38 µM -0.744283159859933 0.232305743209647 no 2590 0.22835259350416 3715 2980291 SGTC_2999 9069765 71.4286 µM -0.745729466557782 0.231878837231367 no 2591 0.227915427626532 3774 2097066 SGTC_2622 2-methoxyxanthone 59.94 µM -0.746857109258412 0.231546294598269 no 2592 0.227574909201897 3767 71034 A hepatoprotective. SGTC_2973 9094665 17.96 µM -0.747619896871685 0.231321498812232 no 2593 0.227344729940909 3792 25237061 YIL048W NEO1 SGTC_2860 9025725 38.96 µM -0.747939787958839 0.231227262195072 no 2594 0.227248238461924 3753 40546248 SGTC_1034 k072-0165 12.7 µM -0.748155060575287 0.231163857159388 no 2595 0.227183316939064 3734 5835461 SGTC_1210 3013-0140 750 nM -0.74881822186156 0.230968594814022 no 2596 0.226983387687722 3790 905973 SGTC_1151 3909-8316 15.3 µM -0.749287583091763 0.230830450954931 no 2597 0.226841945081785 3791 800431 SGTC_3012 9080433 71.4286 µM -0.750228182352732 0.230553749790581 no 2598 0.226558644009131 3749 17688859 SGTC_2644 guaiazulene 100 µM -0.750509593661822 0.23047100154546 no 2599 0.226473923978416 3784 3515 A coloring agent. SGTC_3102 9121669 49.47 µM -0.750852697872059 0.230370135130194 no 2600 0.226370655251043 3776 41905072 SGTC_1978 st071761 42 µM -0.751451083871345 0.230194279573311 no 2601 0.226190614556131 3778 5147680 SGTC_33 0986-0033 35.816 µM -0.751893021403668 0.230064449806046 no 2602 0.226057697596652 3688 2848082 SGTC_586 0957-0265 8.15 µM -0.752057934482401 0.230016013126664 no 2603 0.226008109716796 3634 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1400 3771-8998 51.5 µM -0.752708686693354 0.22982493616283 no 2604 0.225812494396819 3691 670767 SGTC_834 0312-0008 75.7 µM -0.756174787582152 0.228808701788414 no 2605 0.224772203499736 3756 6385573 YIL048W NEO1 SGTC_1808 st050063 61.5 µM -0.756635032989951 0.228673951304515 no 2606 0.224634273389224 3739 4011993 SGTC_1414 3917-0015 5.4 µM -0.75851237127458 0.228124766721752 no 2607 0.224072154882501 3741 6618702 SGTC_2435 5706476 10.6 µM -0.758926738449466 0.228003650378272 no 2608 0.223948191495124 3777 5725375 SGTC_2905 7799065 20.05 µM -0.759025228521859 0.227974867807487 no 2609 0.223918732628162 3683 1296806 SGTC_1553 gossypol 38.6 µM -0.759074202285226 0.227960556559271 no 2610 0.223904085153468 3666 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_311 1315-0136 58 µM -0.759288275825289 0.227898005332095 no 2611 0.223840064676151 3808 6759207 SGTC_2114 5491910 81.25 µM -0.760154691368811 0.227644941663153 no 2612 0.223581062173828 3838 2849228 SGTC_985 1493-0307 8.71 µM -0.760598191943001 0.227515464736827 no 2613 0.223448550016684 3756 3278274 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.761386551901779 0.227285410914355 no 2614 0.223213108735193 3782 5106787 A p450 inhibitor. SGTC_1035 k081-0041 55.2 µM -0.762008951628427 0.227103879106125 no 2615 0.223027330763303 3759 731709 SGTC_885 0865-0106 16.8 µM -0.762357025322999 0.227002394068468 no 2616 0.222923473837963 3711 2793380 SGTC_1039 k821-0043 94 µM -0.762729677138348 0.226893771337447 no 2617 0.222812313927889 3734 15992768 SGTC_3106 9121286 49.47 µM -0.763609674506028 0.226637380952564 no 2618 0.222549941128071 3779 15943471 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.765949756522774 0.225956385865428 no 2619 0.221853099181162 3779 689007 SGTC_3024 9090631 49.47 µM -0.766889033102044 0.225683369565573 no 2620 0.22157374733359 3719 25236383 SGTC_138 0850-0259 40.9225 µM -0.769238837627137 0.22500117806844 no 2621 0.220875769258717 3802 6813004 SGTC_1258 0671-0043 57.1 µM -0.770279417850485 0.22469945223019 no 2622 0.220567081389412 3811 4298767 SGTC_1126 isoteolin 1.0172 µM -0.77122727415214 0.22442481237667 no 2623 0.220286115294986 3763 133323 SGTC_2673 kobusone 100 µM -0.773228136595118 0.223845691661263 no 2624 0.219693688582668 3825 6710676 An epoxy ketone and protein crosslinker. SGTC_2763 lisinopril 49.32 µM -0.774150536075823 0.223579002753986 no 2625 0.219420887672064 3732 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_660 4031-1742 102 µM -0.774570743298644 0.223457570205843 no 2626 0.219296675366777 3708 6738706 SGTC_327 1273-0057 3.96 µM -0.774959030997776 0.22334539520417 no 2627 0.219181934333264 3708 3108138 SGTC_1284 0929-0043 16 µM -0.775513447030495 0.223185281845625 no 2628 0.219018161350889 3778 1239883 SGTC_2054 5233173 129 µM -0.776781398498256 0.222819347731579 no 2629 0.218643876594341 3818 6889 SGTC_589 1227-0070 34.1 µM -0.777111907835561 0.222724018072346 no 2630 0.218546374551986 3827 2841384 SGTC_2518 prenyletin 46.28 µM -0.778772805363435 0.222245313177216 no 2631 0.218056779962134 3759 3873459 A coumarin with calcium channel inhibitory activity. SGTC_77 0828-0286 12.516 µM -0.780106325369929 0.221861390509404 no 2632 0.217664146792178 3758 745345 SGTC_2056 5235370 200 µM -0.780435425102645 0.22176670044803 no 2633 0.217567311551033 3797 5511916 SGTC_1596 piperlongumine 63 µM -0.781038699322944 0.221593183628868 no 2634 0.217389867006647 3793 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2857 9024691 58.44 µM -0.781811078788245 0.221371141199817 no 2635 0.217162804578594 3881 16478292 SGTC_474 dl-dihydrosphingosine 5 µM -0.782938280440565 0.221047323483039 no 2636 0.216831678301951 3808 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2906 7926292 26.41 µM -0.783823581489015 0.220793188115245 no 2637 0.216571817433204 3781 2966319 SGTC_2460 5552655 174.22 µM -0.784743515756742 0.220529288247229 no 2638 0.216301981712963 3804 5401989 SGTC_2745 rifampicin 24.3 µM -0.785347588885427 0.220356097240919 no 2639 0.216124900498531 3768 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_620 0109-0052 432 µM -0.785376794766594 0.220347725734579 no 2640 0.216116341059284 3774 493037 SGTC_2799 7812892 81.82 µM -0.785480833069722 0.220317905917151 no 2641 0.216085851893924 3816 20205235 SGTC_1228 0124-0032 52.5 µM -0.78604158140941 0.220157222138442 no 2642 0.215921563507576 3881 X1228 SGTC_2175 5807670 165.306 µM -0.787082424974231 0.219859144157459 no 2643 0.215616808457167 3779 241186 SGTC_2069 5228469 200 µM -0.787915674573154 0.219620684206669 no 2644 0.21537301599098 3785 2835210 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.789549257645747 0.219153615551798 no 2645 0.214895526066774 3844 165506 SGTC_1156 4092-0367 4.88 µM -0.79036005187318 0.218922008182587 no 2646 0.214658762609261 3838 1357585 SGTC_2669 eugenol 100 µM -0.791877623201808 0.218488885073441 no 2647 0.214216017845836 3774 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_468 gf-109203x 121 µM -0.791970358231224 0.218462433999671 no 2648 0.214188980044301 3766 2396 A protein kinase C inhibitor. SGTC_536 3852-0578 10.6 µM -0.792604849072549 0.218281505869756 no 2649 0.214004041331197 3848 2869208 SGTC_3205 9113483 49.47 µM -0.79269895358956 0.218254678865471 no 2650 0.213976620061022 3891 17018033 SGTC_2218 6965428 192.983 µM -0.793473456814985 0.218033958218582 no 2651 0.21375101399279 3757 675684 SGTC_2160 5660466 132.927 µM -0.793531437256633 0.218017439927677 no 2652 0.213734130369083 3752 2859134 SGTC_556 4058-0063 51.5 µM -0.794744796380664 0.217671926528815 no 2653 0.213380984323706 3877 6615692 SGTC_859 0439-0102 54.6 µM -0.795199087709493 0.217542644893009 no 2654 0.213248851196339 3798 610143 SGTC_2858 9025781 8.96 µM -0.795278425158208 0.217520071691507 no 2655 0.213225780358586 3798 4894980 YPL153C RAD53 SGTC_2139 5578692 56.4705 µM -0.795421819753682 0.217479276291553 no 2656 0.213184085793075 3754 650991 YMR113W FOL3 SGTC_60 0986-0278 202 µM -0.7954380123783 0.21747466980833 no 2657 0.213179377794159 3695 3110598 SGTC_2912 7964298 10.93 µM -0.797134045242728 0.21699249381346 no 2658 0.212686592831892 3881 2975850 SGTC_956 1185-0240 191 µM -0.797759227314002 0.216814912786654 no 2659 0.21250511312978 3831 1416193 SGTC_1218 1348-1416 30.7 µM -0.797885327591984 0.216779104580189 no 2660 0.212468519333672 3781 6787668 SGTC_2059 5238311 157 µM -0.800376752000361 0.216072325998393 no 2661 0.211746273160102 3841 703021 SGTC_1619 st003326 88.7 µM -0.801371740825336 0.215790436438433 no 2662 0.2114582349404 3773 2849032 SGTC_1365 1672-3266 55.4 µM -0.803173049463272 0.215280651613759 no 2663 0.210937360184337 3838 6415873 SGTC_477 mead ethanolamide 10 µM -0.804024336837887 0.215039973839814 no 2664 0.210691459977995 3696 16061185 SGTC_942 3253-1115 227 µM -0.804991830769276 0.21476663167625 no 2665 0.210412196981662 3888 46497897 SGTC_3009 9080819 71.4286 µM -0.808980658815336 0.213641818187324 no 2666 0.209263135735994 3868 17027216 SGTC_2648 atorvastatin 78.68 µM -0.809194121314246 0.213581720594996 no 2667 0.209201747916748 3839 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1755 st041960 45.185 µM -0.809217611927909 0.2135751077197 no 2668 0.209194993103515 3899 2257073 SGTC_2185 6113692 200 µM -0.81200107846542 0.21279237513892 no 2669 0.208395506331627 3835 874150 SGTC_1510 1123-0200 71.5 µM -0.813625923090795 0.21233623125057 no 2670 0.20792964127647 3900 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1224 0823-0416 294 µM -0.815277456235151 0.21187318116497 no 2671 0.207456754983108 3934 3598164 SGTC_1468 k284-1086 134 µM -0.815419818985588 0.211833293756657 no 2672 0.207416021796871 3857 15996457 SGTC_1398 3558-0053 112 µM -0.818292687402477 0.211029308544673 no 2673 0.206595040325192 3760 4532369 SGTC_1522 st012842 45.6 µM -0.818354851756179 0.211011931363648 no 2674 0.206577296877304 3754 3491067 YOR116C RPO31 SGTC_1009 4106-0057 9.87 µM -0.818446064514248 0.210986435623358 no 2675 0.206551263834971 3814 2928005 SGTC_587 k089-0003 57 µM -0.820843268112974 0.210317018263423 no 2676 0.205867774625747 3773 9659696 SGTC_53 0973-0023 39.979 µM -0.822408117755714 0.209880708696672 no 2677 0.205422330389716 3776 674768 SGTC_183 3914-0051 30.55 µM -0.824050560346374 0.209423337485882 no 2678 0.204955415050123 3897 1596232 SGTC_2382 9035899 200 µM -0.824339397707547 0.209342965584935 no 2679 0.204873369338599 3862 6462679 SGTC_935 2996-0153 430 µM -0.824668777278187 0.209251334563224 no 2680 0.204779831245504 3849 23738523 SGTC_2347 9049783 174.81 µM -0.827921161694026 0.208347812901716 no 2681 0.203857574812851 3906 6467988 YPL169C MEX67 SGTC_2119 5528445 120.635 µM -0.829717812315116 0.207849686541126 no 2682 0.203349174071195 3894 791935 SGTC_2932 9016711 44.54 µM -0.830730921251586 0.20756910966606 no 2683 0.203062827105916 3890 7117328 SGTC_1610 st001799 48.1 µM -0.832540856256044 0.207068412147944 no 2684 0.202551863424848 3783 621897 SGTC_294 k038-0071 157 µM -0.833070490748792 0.206922030163497 no 2685 0.202402487524423 3885 24152826 SGTC_404 fumagillin 50 µM -0.833965585992261 0.206674780288285 no 2686 0.202150188389631 3868 12015870 A methionine aminopeptidase binder. SGTC_808 0711-0032 135 µM -0.834144624544589 0.206625345930385 no 2687 0.20209974565799 3824 4252555 SGTC_1524 corynanthine 62.1 µM -0.834921854705303 0.206410826007584 no 2688 0.201880854388808 4009 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2369 9071472 200 µM -0.835132457642881 0.206352721136466 no 2689 0.201821566749632 3960 17296037 SGTC_400 oxethazaine 37.5 µM -0.836423278165828 0.205996798517132 no 2690 0.201458410753603 3911 4621 A local anesthetic. SGTC_249 wiskostatin 11.211 µM -0.837137171976804 0.205800110455539 no 2691 0.201257734061699 3856 2775510 A n-wasp and actin depolymerizer. SGTC_2373 9071805 200 µM -0.838187186776537 0.205511018773433 no 2692 0.200962791088121 3835 10149009 SGTC_983 1491-0821 12.2 µM -0.838373549638576 0.205459734271929 no 2693 0.200910469967636 3899 46495113 SGTC_1789 tunicamycin 25 nM -0.838397633182553 0.205453107365763 no 2694 0.200903709141774 3814 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2920 7982904 15.77 µM -0.839339659510886 0.205193995936191 no 2695 0.200639366968049 3902 6456808 SGTC_1923 st058458 19.1 µM -0.839932779440617 0.205030953496858 no 2696 0.20047303866027 3893 3534982 SGTC_673 1082-0474 110 µM -0.839989723432111 0.205015304244134 no 2697 0.200457074245089 3897 3098046 SGTC_386 1509-0011 3.07 µM -0.840319934379217 0.204924570220006 no 2698 0.200364513689894 3931 3107280 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.840914235334172 0.204761330779891 no 2699 0.200197991467219 3868 803109 SGTC_2476 5806916 10.51 µM -0.842163148190283 0.204418538152524 no 2700 0.199848319142901 3788 2870194 SGTC_431 k089-0097 107 µM -0.842366538610967 0.20436274537354 no 2701 0.199791408417463 3790 5499420 SGTC_458 nppb 133 µM -0.844360452134354 0.203816267788978 no 2702 0.199234007362625 3889 4549 A chloride channel blocker. SGTC_3015 9080845 49.47 µM -0.845588883095521 0.203480022253772 no 2703 0.198891064673169 3979 5296973 SGTC_674 0498-0004 451 µM -0.846332344766323 0.203276683112801 no 2704 0.198683684438178 3912 4231473 SGTC_3225 9130819 49.47 µM -0.847075086089835 0.203073662129594 no 2705 0.198476635392234 3845 4547121 SGTC_1077 5-fluorocytosine 377 nM -0.847225115027471 0.203032667907595 no 2706 0.19843482863373 3920 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.847307829470304 0.203010068952863 no 2707 0.198411781867699 3918 551469 SGTC_1054 3429-0080 167 µM -0.848088350106022 0.202796891770894 no 2708 0.19819438455519 3917 1162877 SGTC_1063 disulfiram 1.84 µM -0.848089108058396 0.202796684822617 no 2709 0.198194173513695 3881 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2308 7584454 197.62 µM -0.848152764220487 0.202779304849643 no 2710 0.198176449808183 3914 893577 SGTC_1185 1319-0113 81.3 µM -0.848525953600238 0.202677431260832 no 2711 0.198072562405872 3962 4672763 SGTC_2052 5265182 7.135 µM -0.848947605505221 0.202562365135152 no 2712 0.197955223719524 3918 1239884 SGTC_534 k292-0788 63.4 µM -0.849730646661863 0.202348781803288 no 2713 0.197737427850933 3894 4146317 SGTC_1913 st060213 96.1 µM -0.850017292888828 0.202270629491259 no 2714 0.197657735996291 3952 688959 SGTC_87 0100-0052 35.5 µM -0.850895732635086 0.202031240827474 no 2715 0.197413637788307 3979 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.85262519059655 0.201560432120757 no 2716 0.196933594246482 3905 442882 SGTC_2819 7996655 46.38 µM -0.853184927904949 0.201408196275754 no 2717 0.196778380135527 3862 6456960 SGTC_3345 9148410 3.559 µM -0.85361874951421 0.20129025405966 no 2718 0.196658133187727 3875 4903596 SGTC_1565 sinapyl alcohol 95.1 µM -0.85451259071765 0.201047377810273 no 2719 0.196410518091801 3948 5280507 A phenol propionate derived from cinnamic acid. SGTC_2499 avocadenofuran 51.48 µM -0.855266084320166 0.200842773690846 no 2720 0.196201929448545 3897 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2946 9065502 71.43 µM -0.856048598328677 0.200630421673077 no 2721 0.195985449366896 3757 16489101 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.856059812006126 0.200627379580384 no 2722 0.19598234819119 3988 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3251 9135047 49.47 µM -0.85756790836567 0.200218509329083 no 2723 0.195565550941608 3916 17682963 SGTC_1919 st067113 52.3 µM -0.85770090558912 0.200182475591157 no 2724 0.195528819932605 3975 1268243 SGTC_330 1488-0319 80.1 µM -0.85782996638461 0.200147512099759 no 2725 0.195493180086975 3953 6846614 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.858637217937014 0.199928905175673 no 2726 0.19527034892957 3968 6708561 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.859573257346213 0.199675601837201 no 2727 0.195012160895937 3974 688788 SGTC_502 l-744,832 89.3 µM -0.860117256532375 0.199528477982753 no 2728 0.194862204841393 3919 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_3054 9094397 49.47 µM -0.862617903497495 0.198853021062659 no 2729 0.194173791730898 3934 2598354 SGTC_2076 5212012 200 µM -0.862873725804777 0.198783997968166 no 2730 0.194103449004467 3827 604802 SGTC_1362 1611-0397 101 µM -0.862981538058274 0.198754913606677 no 2731 0.194073808828461 3886 27816 SGTC_2431 5490079 200 µM -0.863998346851133 0.198480736739934 no 2732 0.193794399346562 3984 5722345 SGTC_2180 6301957 200 µM -0.864719917552351 0.19828630767916 no 2733 0.193596267347204 3903 845462 SGTC_2943 9068529 45.32 µM -0.864799387863133 0.198264901231406 no 2734 0.193574453600782 3918 3270634 SGTC_2773 thioridazine 9.09 µM -0.8667472482794 0.197740653784011 no 2735 0.193040255612508 3939 5452 An antipsychotic. SGTC_1050 3232-1156 69.3 µM -0.868484187208937 0.197273881024512 no 2736 0.192564662574719 3913 700529 SGTC_1420 4'-methoxyflavone 42 µM -0.868592559906876 0.197244779814681 no 2737 0.192535012690907 3893 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2851 9015922 71.43 µM -0.869874741734505 0.196900674001653 no 2738 0.192184430092032 3938 2996893 SGTC_2795 7780010 54.55 µM -0.869902964744947 0.196893103735739 no 2739 0.192176717565907 3944 953673 SGTC_1568 digitonin 820 nM -0.870045385511906 0.196854904862257 no 2740 0.192137801010162 3896 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.871843448755956 0.196373029828516 no 2741 0.191646893993475 3966 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1276 0871-0068 94.2 µM -0.87288091608671 0.196095317567904 no 2742 0.191363994601061 3939 3414906 SGTC_1429 4049-0205 9.46 µM -0.872989400850092 0.196066291814804 no 2743 0.191334427470075 3942 22774478 SGTC_465 cgp-37157 41 µM -0.874318646250302 0.195710855806943 no 2744 0.190972373798493 3887 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3281 9140613 49.47 µM -0.875306187163825 0.195447043904721 no 2745 0.190703664263032 3954 16013766 SGTC_2845 9003024 42.97 µM -0.8754041163634 0.195420894852743 no 2746 0.190677030414445 4000 2990173 SGTC_700 3453-2283 142 µM -0.87547357961849 0.195402348064747 no 2747 0.190658139845735 4000 565664 SGTC_444 curcumin 90.4 µM -0.876693247429251 0.19507686925701 no 2748 0.190326637729624 3897 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2567 aureobasidin a 60 nM -0.876853473876715 0.195034135960346 no 2749 0.190283114978537 4111 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1782 st039423 80.636 µM -0.87720317329776 0.19494088892026 no 2750 0.190188146397219 3969 2068169 SGTC_3095 9117207 49.47 µM -0.877634528058291 0.194825905906009 no 2751 0.190071042633979 3919 17015229 SGTC_359 0081-0058 15.9 µM -0.877796242201262 0.19478280960887 no 2752 0.190027152061597 3970 3494159 SGTC_2847 9005661 71.43 µM -0.878664461930272 0.194551531007578 no 2753 0.189791616475528 3914 2991449 SGTC_133 0724-0033 378.92 µM -0.879711190266022 0.194272923130643 no 2754 0.189507892869049 3785 280309 SGTC_1650 st011916 45.8 µM -0.880094493375255 0.19417096007592 no 2755 0.18940406098995 3864 242528 SGTC_1363 1636-0063 10.4 µM -0.880156863846076 0.194154371894212 no 2756 0.18938716894495 3932 6072185 SGTC_2998 9066762 71.4286 µM -0.884364514074679 0.19303729062976 no 2757 0.18824973625881 3976 4945196 SGTC_1360 1598-0022 39.8 µM -0.88664353532158 0.192433879398336 no 2758 0.187635423557943 4018 761525 SGTC_491 tetrandrine 80.3 µM -0.887681377891315 0.192159474792581 no 2759 0.187356082844939 3969 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2681 menadione 3.18 µM -0.888196510729898 0.192023363094444 no 2760 0.187217527688686 3976 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2764 methyldopa 94.69 µM -0.889997902649768 0.191547851875358 no 2761 0.186733506128839 3944 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_560 2332-1943 155 µM -0.890502813437962 0.191414700731542 no 2762 0.186597979198126 3927 21177716 SGTC_685 1278-0033 54.9 µM -0.892427876905213 0.190907558542583 no 2763 0.186081817326776 3978 3590572 SGTC_2033 5192550 145 µM -0.892685193635865 0.190839833066678 no 2764 0.186012890833425 3940 182073 SGTC_735 3076-0345 636 µM -0.893375554997968 0.190658203569161 no 2765 0.185828044470061 4032 2888990 SGTC_2469 5655019 90.81 µM -0.894275600906166 0.190421566855724 no 2766 0.185587225581979 4027 2788239 SGTC_3034 9090421 49.47 µM -0.894368922036814 0.19039704153644 no 2767 0.185562267395695 3837 17173761 SGTC_1810 st050138 53 µM -0.894597405196263 0.190337003063561 no 2768 0.185501169714863 3924 3444541 SGTC_1408 3909-7976 48.8 µM -0.899428878237425 0.189070162048115 no 2769 0.184212131478372 4019 24152374 SGTC_2737 bleomycin 30.5 nM -0.89959772077986 0.1890259846462 no 2770 0.184167185290118 3996 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_415 dibenzyl ketone 100 µM -0.899923234358493 0.188940832446169 no 2771 0.184080552257273 3983 7593 SGTC_3261 9137475 49.47 µM -0.901157246576177 0.188618237673015 no 2772 0.183752359471329 3871 17027690 SGTC_2263 7948595 193.29 µM -0.90141306845357 0.188551403382511 no 2773 0.183684367786921 3953 2971371 SGTC_3065 9113888 49.47 µM -0.902874743693113 0.18816981614338 no 2774 0.183296188187415 4042 16648368 SGTC_2524 avocatin b 10.57 µM -0.904695299264392 0.187695206015029 no 2775 0.182813416062427 3928 6710748 SGTC_2533 agelasine 13.65 µM -0.905685628410727 0.187437342761338 no 2776 0.182551135722768 4046 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_3346 9158254 43.5805 µM -0.907664713516763 0.186922682298393 no 2777 0.182027696223377 3990 17639500 SGTC_1023 4482-3888 16 µM -0.908494239846101 0.18670722454654 no 2778 0.181808577840659 4010 3303168 SGTC_1272 0839-0021 27 µM -0.910554019855262 0.186172890959258 no 2779 0.181265203307979 4004 5027250 SGTC_3253 9135987 49.47 µM -0.912358408875688 0.185705588691673 no 2780 0.180790038100345 3982 4182430 SGTC_1332 1480-0653 17.5 µM -0.912687302287622 0.185620490057096 no 2781 0.180703511991267 3993 5749438 SGTC_639 0833-0042 114 µM -0.913920079032054 0.185301733953953 no 2782 0.180379421082059 3982 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1295 1013-0063 9.78 µM -0.91440783841454 0.185175709086958 no 2783 0.180251292307552 3986 6826038 SGTC_1084 voriconazole 435 nM -0.915366352573104 0.184928208056998 no 2784 0.179999668134942 3984 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_135 0933-0004 26.348 µM -0.915517676232236 0.184889153084074 no 2785 0.17995996360019 3981 21230617 YGL099W LSG1 SGTC_810 3825-7150 143 µM -0.916505539929259 0.184634322295265 no 2786 0.179700901563495 4061 22330411 YGL099W LSG1 SGTC_3142 9086498 49.47 µM -0.918334369193672 0.184163131522544 no 2787 0.179221919546881 3917 25236367 SGTC_1851 st056236 18.9 µM -0.918920973153558 0.184012153962235 no 2788 0.179068454478662 3957 5393171 SGTC_2318 6029776 164 µM -0.919579294382101 0.183842809925728 no 2789 0.178896325501804 4006 818325 SGTC_1674 st016616 23.6 µM -0.920295633989197 0.183658651778779 no 2790 0.178709145007672 3963 625830 SGTC_2445 5742597 35.57 µM -0.922014131696327 0.183217325490769 no 2791 0.178260602232355 3961 1774255 SGTC_1706 st031321 9.9705 µM -0.922817631786348 0.183011206260648 no 2792 0.178051125382672 4015 6103185 SGTC_2523 spermine 47.74 µM -0.923484123202279 0.18284034324031 no 2793 0.177877485250266 4000 1103 A DNA binding polyamine. SGTC_2337 9009472 200 µM -0.924293868155147 0.182632889486441 no 2794 0.17766666721913 3951 5742383 SGTC_2381 9035592 200 µM -0.925003032531043 0.182451324897352 no 2795 0.177482165011858 4002 4749657 SGTC_767 0929-0023 86 µM -0.925779182381238 0.182252739563968 no 2796 0.177280373969187 4025 1204563 SGTC_1868 st057644 42.7 µM -0.925800047491113 0.182247402891982 no 2797 0.177274951254032 4011 688665 SGTC_866 0495-0101 262 µM -0.929552204651812 0.181289301404547 no 2798 0.176301491887866 3967 635694 SGTC_2411 st077133 39.94 µM -0.929556008678046 0.181288331661764 no 2799 0.176300506691115 4112 1403142 YNL221C POP1 SGTC_972 1319-0219 195 µM -0.929816771124372 0.181221864443002 no 2800 0.176232980678199 3981 23903702 SGTC_999 SEC7.066 22.7 µM -0.933403638369578 0.180309136924647 no 2801 0.17530580127662 3995 740511 YDR170C SEC7 SGTC_1454 4239-0054 42.6 µM -0.936472294212409 0.179530569253025 no 2802 0.174515035490483 4128 1340767 SGTC_3136 9095672 49.47 µM -0.937613937376381 0.179241455996479 no 2803 0.174221423118353 3742 17217380 SGTC_1682 st012968 530 nM -0.938921847019048 0.178910597004845 no 2804 0.173885435742093 4032 24207270 SGTC_2487 5918373 44.05 µM -0.940649077401647 0.178474252752851 no 2805 0.173442361402914 4083 2876279 SGTC_1672 st016598 6.51 µM -0.941447176807582 0.178272858288368 no 2806 0.173237873497086 4056 4665860 YNL267W PIK1 SGTC_846 0335-0850 148 µM -0.941558102823405 0.178244878271385 no 2807 0.173209464346093 4008 6819598 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.941585536400291 0.178237958843267 no 2808 0.173202438817774 4059 5379071 SGTC_2899 9053889 58.44 µM -0.94221593820773 0.178079002523826 no 2809 0.173041047756618 3980 6470052 SGTC_1132 3456-3614 2.5 µM -0.942452533207611 0.178019367978036 no 2810 0.172980501092301 4109 3125502 SGTC_208 k072-0098 12.366 µM -0.943453341372108 0.177767250305065 no 2811 0.172724535134503 4006 5948901 SGTC_3043 9092303 49.47 µM -0.944978935214718 0.177383365354771 no 2812 0.172334815179692 4025 25236084 SGTC_505 gw-5074 63.9 µM -0.946990592014994 0.176877973198931 no 2813 0.171821786472603 4078 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2148 5546263 113.568 µM -0.950529198418586 0.175991173654448 no 2814 0.170921712454186 4016 792097 SGTC_716 1683-5115 658 µM -0.951070236956707 0.175855834150993 no 2815 0.170784361147598 3975 723597 SGTC_1482 3346-2049 8.48 µM -0.951632890083093 0.175715157750935 no 2816 0.170641597579991 4024 3826804 SGTC_3129 9127257 49.47 µM -0.951758728982843 0.175683704850519 no 2817 0.17060967857739 4015 837894 SGTC_352 k048-0007 5.11 µM -0.952048568458473 0.175611274270992 no 2818 0.170536175415393 4026 6811911 SGTC_263 alizarin 107.927 µM -0.952806898101276 0.175421858029096 no 2819 0.170343959298642 4043 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3289 9119912 71.43 µM -0.9533357607846 0.175289834933447 no 2820 0.170209989042457 4089 17014829 SGTC_1547 harmine 94.2 µM -0.954407621126948 0.175022453449997 no 2821 0.169938675016726 4014 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_250 brefeldin a 552.239 µM -0.95505737210768 0.174860495520005 no 2822 0.169774342226886 3901 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_968 1309-0633 340 µM -0.955741734260822 0.174690013241681 no 2823 0.169601365933416 4087 3761976 SGTC_2802 7925815 54.55 µM -0.957500185789669 0.174252447390637 no 2824 0.169157426335302 4010 1262923 SGTC_340 k038-0059 454 µM -0.95798485415299 0.174131967049223 no 2825 0.16903519799114 4019 23733424 SGTC_849 0386-0493 241 µM -0.95816052255425 0.174088311938221 no 2826 0.168990910247887 4013 726119 SGTC_1844 rapamycin 4 nM -0.958579591914903 0.173984197689221 no 2827 0.168885288813516 3950 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1624 st003710 6.25 µM -0.960570018914113 0.173490233601321 no 2828 0.168384204680432 4086 24207033 SGTC_833 3852-0053 558 µM -0.961957564011496 0.173146415186352 no 2829 0.16803546045677 4119 3123681 SGTC_827 3253-0474 693 µM -0.962221262696957 0.173081122659392 no 2830 0.167969235289873 4088 5402065 SGTC_3224 9130643 49.47 µM -0.96334043401355 0.172804187294948 no 2831 0.167688354097626 4099 17644395 SGTC_1843 st055809 45.5 µM -0.963552106367455 0.172751841422964 no 2832 0.167635264198444 4116 16413835 SGTC_2320 7373003 200 µM -0.96640551290088 0.172047190108423 no 2833 0.166920653278761 4136 5415828 SGTC_2914 7968218 45.32 µM -0.967134350463507 0.171867497601994 no 2834 0.166738437733684 4009 2977111 SGTC_2963 9082507 9 µM -0.971620055152063 0.17076420180741 no 2835 0.165619800778413 4110 16459611 SGTC_2121 5257820 149.641 µM -0.972149537692938 0.17063427100115 no 2836 0.165488080360659 4101 791256 SGTC_2492 derrusnin 100 µM -0.972392721739162 0.170574616784159 no 2837 0.165427605700294 4013 1715307 Part of coumarin class of compounds. SGTC_2391 6285546 200 µM -0.972957573946908 0.170436107352932 no 2838 0.165287194240296 4043 846083 SGTC_232 clozapine 119 µM -0.974050239453656 0.170168375436722 no 2839 0.165015797443421 4007 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2276 7947513 42.08 µM -0.974346697264675 0.170095781944262 no 2840 0.164942212895493 4012 2105100 SGTC_737 1950-0117 57.9 µM -0.975115799761409 0.169907544706554 no 2841 0.16475141109252 4026 5393513 SGTC_2740 felodipine 17.08 µM -0.979230874087434 0.168902653566543 no 2842 0.163732958442247 4073 3333 L-type calcium channel blocker SGTC_81 0411-0046 9.971 µM -0.979847338443659 0.168752443969901 no 2843 0.163580740467131 4007 12925265 SGTC_3047 9092122 49.47 µM -0.980799073688885 0.168520709867856 no 2844 0.163345917578756 4041 17173831 SGTC_648 0375-0473 33.3 µM -0.98180303634065 0.168276480980446 no 2845 0.163098446014113 4035 1713139 SGTC_3085 9117376 49.47 µM -0.985698989691782 0.167330889521345 no 2846 0.16214042270397 4157 16480349 SGTC_222 nsc-310342 10.666 µM -0.98654993893366 0.167124811164928 no 2847 0.16193166104408 4054 432556 SGTC_1950 st077106 7.18 µM -0.988590714937634 0.166631253995306 no 2848 0.161431715442432 4038 13831864 SGTC_672 1441-0018 53.7 µM -0.990059445960949 0.166276627369236 no 2849 0.161072531919073 4063 251141 SGTC_466 geldanamycin 89.2 µM -0.992219493945535 0.16575596779015 no 2850 0.160545232547668 3997 5288382 HSP90 inhibitor. SGTC_1529 apigenin 74 µM -0.993227541946082 0.165513348264531 no 2851 0.160299539608444 4117 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_788 1182-0090 188 µM -0.993594325684467 0.16542512685672 no 2852 0.160210203904277 4127 5715185 SGTC_1407 3909-7909 12.3 µM -0.994106258570128 0.165302044025282 no 2853 0.160085569361307 4064 4411780 SGTC_1618 st003135 44.5 µM -0.994132413202629 0.165295757319455 no 2854 0.160079203489664 3996 1270615 SGTC_1198 1612-1005 86.7 µM -0.995399895762842 0.164991282001162 no 2855 0.159770904643838 4159 6998509 SGTC_2605 digitonin 300 nM -0.995780216928779 0.164899991929771 no 2856 0.159678472226336 4129 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2147 5545932 89.7195 µM -0.996506211523201 0.164725819267234 no 2857 0.15950212527233 4100 797404 SGTC_3333 9141820 12.094 µM -1.00059811309165 0.163746364991234 no 2858 0.158510571354539 4077 1939433 SGTC_3237 9133362 49.47 µM -1.00290602571574 0.163195604421985 no 2859 0.157953102501736 4064 43845137 SGTC_2863 9028737 58.44 µM -1.00381507024233 0.162979000756974 no 2860 0.157733879529587 4059 6460917 SGTC_3277 9138724 49.47 µM -1.00577190601874 0.162513367877854 no 2861 0.157262652243028 4037 15943418 SGTC_455 paf C-16 10 µM -1.00867734543639 0.161823611338048 no 2862 0.156564700008202 4075 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1239 0337-0584 35.4 µM -1.01071954692926 0.161339932344596 no 2863 0.156075339397841 4167 914301 YML130C ERO1 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.01339286112252 0.160708205889353 no 2864 0.155436273965922 4140 5357218 A potent inhibitor of glutathione S-transferases. SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.01410478377342 0.160540245354053 no 2865 0.155266377810659 4093 140250 A respiratory chain inhibitor. SGTC_539 4859-0462 2.54 µM -1.01496562733471 0.160337303831771 no 2866 0.155061106325724 4149 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2918 7977171 22.06 µM -1.01497418553784 0.160335287100747 no 2867 0.155059066489006 4076 2236483 SGTC_2823 7987624 58.44 µM -1.01722220920494 0.159806116920618 no 2868 0.154523866526205 4117 2239440 SGTC_2208 7283366 200 µM -1.01770097592037 0.159693566086854 no 2869 0.154410041674821 4088 898663 SGTC_3298 9116858 71.43 µM -1.0222895097536 0.158617502417708 no 2870 0.153321948371749 4174 2506942 SGTC_1011 4112-3381 17.4 µM -1.02257458910539 0.158550805288103 no 2871 0.153254514638369 4186 2877139 SGTC_748 act1.228 77.9 µM -1.02261660835278 0.158540976025729 no 2872 0.153244576910877 4058 4421505 YNR035C ARC35 SGTC_3313 9133968 57.047 µM -1.02562457270347 0.157838382692526 no 2873 0.152534290114715 4110 1494643 SGTC_2289 7946404 165.07 µM -1.02661782951733 0.157606829846281 no 2874 0.152300227570147 4138 1246120 YPR165W RHO1 SGTC_2295 7971645 200 µM -1.02741833983845 0.15742037350366 no 2875 0.152111759647491 4176 2978226 YKL099C UTP11 SGTC_3177 9107506 49.47 µM -1.03127608527066 0.156523854005838 no 2876 0.151205684842705 4090 8897194 SGTC_175 3793-3120 23.7 µM -1.03173761545813 0.1564168224429 no 2877 0.151097525477891 4130 5322297 SGTC_2519 cryptotanshinone 88.04 µM -1.03441050811349 0.155797910998127 no 2878 0.150472146997727 4114 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1114 scopoletin 1.73284 µM -1.03691273450817 0.155219982843084 no 2879 0.14988826426577 4168 5280460 A coumarin with genotoxic properties. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.03726613984354 0.15513847257024 no 2880 0.149805920736805 4158 6728940 SGTC_1641 st009299 47.1 µM -1.03772938580155 0.155031671192527 no 2881 0.149698030023239 4040 4046054 SGTC_2717 st081029 62.2815 µM -1.03793112559652 0.154985175252477 no 2882 0.149651060715082 4114 5292846 SGTC_184 1494-0393 24.714 µM -1.04050046740466 0.154393812271717 no 2883 0.149053723506607 4104 3090647 SGTC_1143 3454-2408 5.08 µM -1.04136312261584 0.154195597416671 no 2884 0.148853525470703 4117 X1143 SGTC_3314 9135860 59.4275 µM -1.0448082782271 0.15340567274654 no 2885 0.148055794051231 4137 25252478 SGTC_1324 1418-0026 34.4 µM -1.04773360586967 0.152737045239293 no 2886 0.147380679875085 4175 1372513 SGTC_1106 tegaserod maleate 11.7 µM -1.04778512952829 0.152725286082937 no 2887 0.147368807637321 4155 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1615 st002656 86.5 µM -1.04812533258749 0.152647657194447 no 2888 0.147290433103069 4139 1584458 SGTC_3045 9092950 49.47 µM -1.05105820298804 0.151979508832835 no 2889 0.146615929548833 4082 44120432 SGTC_2843 9000894 45.46 µM -1.05300968025784 0.151536013290814 no 2890 0.146168277740998 4071 2242070 SGTC_2525 harmine 47.85 µM -1.05583341324782 0.150895812304255 no 2891 0.145522164910552 4137 5280953 A monoamine oxidase inhibitor SGTC_2941 9056145 11.23 µM -1.05637073453812 0.150774194196313 no 2892 0.145399435515133 4070 2119517 SGTC_354 2783-3500 4.88 µM -1.05652079892468 0.150740240059184 no 2893 0.145365171794613 4162 6740761 SGTC_2307 7538926 6.34 µM -1.06258490514729 0.149372411937138 no 2894 0.143985117700954 4132 96582 SGTC_1453 4237-0541 195 µM -1.06369685480972 0.149122500846578 no 2895 0.143733024865496 4148 739892 SGTC_742 0kpi-0133 140 µM -1.06481118915852 0.148872334113203 no 2896 0.143480690344613 4188 2728852 SGTC_1564 D-Arginine 115 µM -1.06621225930924 0.148558193713917 no 2897 0.14316385079991 4166 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1932 st074806 40.9 µM -1.06687140826706 0.148410556303069 no 2898 0.143014953728283 4240 17251235 SGTC_919 tnp00227 403.569 nM -1.06905303558266 0.147922611426749 no 2899 0.142522886085049 4127 1269246 A methoxyflavone. YNL221C POP1 SGTC_1723 st034307 2.5525 µM -1.07111959597144 0.147461394085435 no 2900 0.142057829081075 4188 867466 SGTC_1693 xanthone 101.9 µM -1.07203028405806 0.147258451848857 no 2901 0.141853215035767 4204 7020 An insecticide. SGTC_2814 7977482 42.97 µM -1.07370201399968 0.14688640273387 no 2902 0.141478129213207 4208 6456762 SGTC_1708 st033234 31.827 µM -1.07482183063396 0.146637536703665 no 2903 0.141227252316496 4266 674664 SGTC_3064 1327-0027 10 µM -1.07543871719511 0.146500561887324 no 2904 0.141089177723536 4084 16000455 YPR107C YTH1 SGTC_1980 st071811 45.7 µM -1.07596793588263 0.146383121499169 no 2905 0.14097079836274 4260 4974850 SGTC_2584 androsterone 48.74 µM -1.08000408481294 0.145489528083229 no 2906 0.140070180592882 4112 2754130 A steroid. SGTC_312 4092-0653 6.84 µM -1.08122034662281 0.145220971555581 no 2907 0.139799554688583 4107 1148278 SGTC_1646 st011709 75.6 µM -1.08287857736213 0.144855363851517 no 2908 0.1394311608938 4127 5757843 SGTC_584 0986-0246 15.4 µM -1.08413925631186 0.144577823658319 no 2909 0.139151529748726 4268 53315 YDR232W HEM1 SGTC_1685 st024049 53.0905 µM -1.08441691101206 0.14451674576759 no 2910 0.139089994494991 4195 1941139 SGTC_2589 lobaric acid 100 µM -1.08518267748481 0.144348384191398 no 2911 0.138920377413992 4166 73157 A novel microtubule depolymerizer. SGTC_1760 st045453 10.4495 µM -1.08671362448984 0.144012186338834 no 2912 0.138581695428421 4225 3323419 YIL048W NEO1 SGTC_331 k048-0133 24.5 µM -1.08796441909337 0.143737902575582 no 2913 0.138305407727987 4146 6813582 SGTC_3042 9091578 49.47 µM -1.08831482336485 0.143661126507721 no 2914 0.138228074393387 4153 25236497 SGTC_2083 5306046 65.942 µM -1.090793965526 0.143118719476416 no 2915 0.137681776181617 4192 539837 SGTC_423 5-fluorouracil 457 µM -1.09420842329871 0.142373943974324 no 2916 0.136931789002254 4117 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2782 7736369 71.43 µM -1.09615728306357 0.141950028102778 no 2917 0.136504974925075 4226 2950836 YOL077C BRX1 SGTC_1602 st001878 87.6 µM -1.09786723227048 0.141578784568388 no 2918 0.136131234132055 4187 595405 YLR310C CDC25 SGTC_1645 Cervolide 78 µM -1.09960405128598 0.141202381346339 no 2919 0.13575233802082 4186 23173 A fragrance. SGTC_3139 9095020 49.47 µM -1.10041647438844 0.141026546221058 no 2920 0.135575351876295 3942 25236292 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.10146852794779 0.140799067922082 no 2921 0.13534639730962 4188 688662 SGTC_3152 9099253 49.47 µM -1.10422847361118 0.140203487640422 no 2922 0.134747020539481 4112 25236131 SGTC_582 0987-0078 156 µM -1.11149987087929 0.138642564874486 no 2923 0.133176622799053 4247 1625765 SGTC_1970 st070122 35.8 µM -1.11306767364061 0.138307568191134 no 2924 0.132839682992411 4228 102928 SGTC_1298 1079-1278 263 µM -1.11318651881752 0.138282196736094 no 2925 0.1328141656807 4179 2840950 SGTC_305 1682-2595 20.8 µM -1.11364630125685 0.138184070767237 no 2926 0.132715477337368 4219 226033 SGTC_2736 butenafine 14.65 µM -1.11494914209369 0.137906278650489 no 2927 0.132436108139758 4132 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1785 bathophenanthroline 24 µM -1.1199360381734 0.136846492567312 no 2928 0.131370509822699 4127 72812 An iron chelator. SGTC_2809 7964133 12.99 µM -1.12117455284928 0.136584155887819 no 2929 0.131106784663674 4215 1253665 SGTC_56 0957-0365 83.25 µM -1.12119824241101 0.136579141424294 no 2930 0.131101743855024 4186 6752360 SGTC_1066 ketoconazole 628 nM -1.12133690346353 0.136549793014266 no 2931 0.131072241400443 4287 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2429 5902844 64.44 µM -1.12346477821835 0.136099956980313 no 2932 0.130620075709764 4220 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1441 4106-0040 13 µM -1.12387476574355 0.136013401656218 no 2933 0.130533078910902 4208 2904180 SGTC_730 1436-0052 41.2 µM -1.12453659550175 0.135873757692491 no 2934 0.130392727321757 4250 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1052 3253-3998 198 µM -1.1250874806009 0.135757597589733 no 2935 0.130275982952586 4149 5450317 SGTC_1489 4065-0444 182 µM -1.12522744948388 0.135728094470739 no 2936 0.130246332068573 4205 2877968 SGTC_1230 0170-0365 3.77 µM -1.12656532763798 0.135446313548519 no 2937 0.129963152753624 4271 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2176 5809774 33.9695 µM -1.1279903932932 0.135146610610898 no 2938 0.129661988151004 4154 2870539 SGTC_590 k048-0076 22.4 µM -1.12827344528311 0.135087136636496 no 2939 0.129602227272293 4249 6832814 SGTC_809 3998-0021 90 µM -1.13063672666824 0.134591272060376 no 2940 0.12910401138832 4177 715485 SGTC_258 haloperidol 50.781 µM -1.1318489278342 0.13433741291632 no 2941 0.128848976730692 4217 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2459 5811157 9.22 µM -1.13271178318263 0.134156914210189 no 2942 0.128667653882137 4193 2870684 YBR192W RIM2 SGTC_396 dithiazanine 1.25 µM -1.13386903689093 0.133915092654319 no 2943 0.12842474342404 4212 10578 An antihelmenthic. SGTC_2048 5246248 200 µM -1.13507754066639 0.133662881736403 no 2944 0.128171415450575 4257 677046 SGTC_1464 k208-0027 110 µM -1.13518857004076 0.133639726648744 no 2945 0.128148158762717 4239 X1464 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.13583578728308 0.133504804907941 no 2946 0.128012648208972 4159 1241132 A phosphatase inhibitor. SGTC_2482 5981709 142.65 µM -1.14188463243653 0.132248365157632 no 2947 0.126750988604271 4173 877755 SGTC_2085 5307070 144.047 µM -1.14210669727993 0.132202394453468 no 2948 0.12670483597901 4175 2840351 SGTC_1262 0737-0114 49.6 µM -1.1421745522352 0.132188349672702 no 2949 0.126690735746606 4286 765919 SGTC_1508 1080-0625 72.9 µM -1.14291567545382 0.132035017192067 no 2950 0.12653680178286 4136 767111 SGTC_2438 5259590 200 µM -1.14300957236456 0.132015599428299 no 2951 0.126517308358951 4246 1201127 SGTC_1382 3002-2117 298 µM -1.14418635150611 0.13177240997335 no 2952 0.126273181066483 4305 1497314 SGTC_3166 9102297 49.47 µM -1.14453114906986 0.131701213785759 no 2953 0.126201713733301 4228 25237072 SGTC_3312 9133330 71.43 µM -1.14744261828686 0.131101091821836 no 2954 0.125599367916443 4273 17617324 SGTC_772 k072-0172 35.3 µM -1.14934368603209 0.130710258207832 no 2955 0.125207145496255 4283 5861980 SGTC_450 aminopyrene 156 nM -1.14941549038244 0.13069551201473 no 2956 0.125192347825129 4188 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1814 st052110 31.539 µM -1.1507874841328 0.1304139716628 no 2957 0.124909837519575 4183 674163 SGTC_958 1222-0007 33 µM -1.15425486784684 0.129704316913355 no 2958 0.124197846914385 4319 7312461 SGTC_3080 9117754 49.47 µM -1.15439693367682 0.129675298045272 no 2959 0.124168735863254 4252 9550191 SGTC_64 000l-0018 272.079 µM -1.15475446334509 0.12960228767205 no 2960 0.124095494722618 4165 6811119 SGTC_3146 9095609 49.47 µM -1.15742797785951 0.129057237514777 no 2961 0.123548774445513 4298 17173999 SGTC_563 tetrahydrosecaminediol 614 µM -1.15745206677428 0.129052333736798 no 2962 0.123543856063925 4291 334274 A psychoactive constituent of the cannabis plant. SGTC_456 gingerol 170 µM -1.158166345847 0.128906986728023 no 2963 0.123398079635039 4287 442793 A herb. SGTC_2549 cedrol 20.94 µM -1.15920101174106 0.128696646355727 no 2964 0.123187129581105 4190 6708665 A sedative which affects the nervous system. SGTC_2064 5220758 200 µM -1.1610382471518 0.1283237363065 no 2965 0.122813172900036 4314 788518 SGTC_419 nsc-638432 893 µM -1.16659253507526 0.127200928351036 no 2966 0.121687479705957 4211 368090 SGTC_2252 omeprazole 400 µM -1.1668985960496 0.12713925696649 no 2967 0.121625661482096 4237 4594 A proton pump inhibitor. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.17203377712763 0.126107618499105 no 2968 0.120591747693287 4255 390807 SGTC_2915 7971052 15.16 µM -1.17229727048962 0.126054841532431 no 2969 0.120538863545181 4164 5741558 SGTC_1644 st010134 20.9 µM -1.1724446821532 0.126025322116229 no 2970 0.120509284572707 4242 3818134 SGTC_3240 9133527 49.47 µM -1.17585368063 0.125344009091961 no 2971 0.119826675501645 4212 17617455 SGTC_462 ag-879 158 µM -1.17917641038291 0.124682416045813 no 2972 0.119163968647216 4303 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_791 1348-1292 225 µM -1.17984810222105 0.124548971714556 no 2973 0.119030317028525 4241 5437054 SGTC_1157 4092-0394 27.6 µM -1.1799710867402 0.124524549324195 no 2974 0.11900585733432 4336 3659885 SGTC_1771 st048882 4.1505 µM -1.18716000182049 0.123102781550977 no 2975 0.117582257300245 4307 4580403 SGTC_2261 9010538 184.68 µM -1.18784205054736 0.122968484612727 no 2976 0.117447821974561 4276 6457250 SGTC_1924 st058459 75.1 µM -1.18842958731619 0.122852879673093 no 2977 0.11733210273139 4220 688683 SGTC_1637 st007924 17.4 µM -1.18958929980849 0.122624915997061 no 2978 0.117103926753646 4194 683336 SGTC_3176 9106582 49.47 µM -1.19318956354094 0.121919106484406 no 2979 0.116397570523772 4251 17018027 SGTC_2038 4100038 30.985 µM -1.1935043055003 0.121857539178839 no 2980 0.116335963484251 4250 3596803 SGTC_2077 5212015 200 µM -1.19604465371202 0.121361416070895 no 2981 0.115839566987979 4154 780900 SGTC_3338 9144300 39.5675 µM -1.19810608137367 0.120959870008542 no 2982 0.115437860823571 4274 4901274 SGTC_3100 9120536 49.47 µM -1.19854950532153 0.120873617647872 no 2983 0.115351581237365 4147 16421196 SGTC_2768 sulfasalazine 50.2 µM -1.19940053204437 0.120708201930839 no 2984 0.115186120412 4277 5384001 An antioxidant and salicylic acid derivative. SGTC_925 2064-1272 59.6 µM -1.20011578876004 0.120569299394044 no 2985 0.115047187221239 4263 6815817 SGTC_977 1348-1378 135 µM -1.20166327587804 0.120269163343472 no 2986 0.114747007502839 4274 X977 SGTC_3231 9132313 49.47 µM -1.20362922647476 0.119888625690937 no 2987 0.114366458974501 4231 4905967 SGTC_3226 9131256 49.47 µM -1.20362963480215 0.119888546741644 no 2988 0.114366380028126 4246 17178073 SGTC_1357 1503-1303 39.5 µM -1.20705588333971 0.119227378353697 no 2989 0.113705311620467 4274 292895 SGTC_805 3852-0218 479 µM -1.20833350359685 0.118981494023392 no 2990 0.11345950313606 4255 6615355 SGTC_2832 7992762 51.95 µM -1.20899228938836 0.118854847458222 no 2991 0.113332903845324 4239 2985177 SGTC_291 SEC14.278 35.5 µM -1.20991559092299 0.118677510028578 no 2992 0.113155642009586 4324 1068044 SGTC_2804 7954240 19.48 µM -1.21075110925091 0.118517194215074 no 2993 0.112995403986284 4313 828705 SGTC_1938 st074717 56.4 µM -1.21082276246752 0.118503452820124 no 2994 0.112981669677248 4177 17250979 SGTC_1369 1866-0067 208 µM -1.21535586287787 0.117636399148152 no 2995 0.11211519712509 4325 3531355 SGTC_2504 purpurogallin 52.29 µM -1.22002398467044 0.11674822283779 no 2996 0.111227891384166 4193 5281571 An antioxidant. SGTC_964 1287-0107 19.4 µM -1.22029648889034 0.116696522312353 no 2997 0.111176250170588 4317 51516812 YPR165W RHO1 SGTC_316 k060-0003 58.6 µM -1.22129265390652 0.116507664281644 no 2998 0.11098761690864 4341 6152314 SGTC_955 1216-0110 33 µM -1.2230621292019 0.116172732888342 no 2999 0.110653115503148 4285 3619719 SGTC_1799 st045822 46.1415 µM -1.22523437030828 0.115762499890047 no 3000 0.11024346401159 4296 3674992 SGTC_1499 4480-0877 67.3 µM -1.22832191482163 0.115181181685578 no 3001 0.109663073739626 4293 2861909 SGTC_1752 st044819 83.042 µM -1.22859631028027 0.115129619520863 no 3002 0.109611599786336 4274 441209 YML126C ERG13 SGTC_1040 k898-0338 155 µM -1.22871945770953 0.115106483993108 no 3003 0.109588504151799 4308 20969351 SGTC_2225 6654152 15.4 µM -1.22966523884097 0.114928911654238 no 3004 0.109411244476155 4213 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_416 estradiol valerate 100 µM -1.23048785742335 0.11477462184351 no 3005 0.109257235641372 4326 13791 A steroid. SGTC_702 1488-0190 94 µM -1.23148490619455 0.11458781364232 no 3006 0.109070779240036 4338 949357 SGTC_763 3453-1109 128 µM -1.23155425427474 0.114574828559996 no 3007 0.1090578190845 4337 1560353 SGTC_1172 0370-0043 85 µM -1.23236358162608 0.114423363473903 no 3008 0.10890664930611 4338 376585 SGTC_1427 4048-4900 550 nM -1.23264532005129 0.114370669774805 no 3009 0.108854060308437 4305 24132586 SGTC_2976 9009005 19.48 µM -1.23404490597997 0.114109160508091 no 3010 0.108593085696047 4332 2993148 SGTC_1934 st074720 32.6 µM -1.23436491458432 0.114049427541986 no 3011 0.108533478370835 4257 17250992 SGTC_800 3448-7362 155 µM -1.23541965530352 0.113852706823202 no 3012 0.108337180694216 4390 15991913 SGTC_104 0074-0074 590.992 µM -1.23715940439774 0.11352875311442 no 3013 0.108013954679103 4130 3943124 SGTC_2667 digitoxin 100 µM -1.23718512480284 0.113523968726612 no 3014 0.108009181328408 4250 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2752 diclazuril 33.15 µM -1.23798447423529 0.113375349194132 no 3015 0.107860908857569 4251 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2291 7917025 104.35 µM -1.24021753356888 0.112960901745764 no 3016 0.10744747243353 4211 2964612 SGTC_2024 5144227 134 µM -1.2426433574621 0.112511904586678 no 3017 0.106999642602233 4319 3475211 SGTC_322 k048-0136 19.3 µM -1.24487969148466 0.112099110889723 no 3018 0.10658798850661 4382 6823282 SGTC_403 arphamenine a 50 µM -1.24569342535168 0.11194917680166 no 3019 0.106438484148514 4298 5487158 An arginine aminopeptidase inhibitor. SGTC_2619 obliquin 87.91 µM -1.24910924342018 0.111321361508002 no 3020 0.10581256013007 4277 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2555 cholic acid 100 µM -1.24953698593793 0.111242921860183 no 3021 0.105734367236438 4273 6708657 Influences liver metabolism. SGTC_1312 1218-2183 165 µM -1.25023235234108 0.111115489669271 no 3022 0.105607340887046 4389 6744073 SGTC_2348 9022543 33.42 µM -1.25105539977601 0.110964793902625 no 3023 0.105457132997335 4344 3162678 YDL140C RPO21 SGTC_449 xestospongin c 11.1929 µM -1.2521734889226 0.110760312106421 no 3024 0.105253327004518 4330 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3214 9129694 49.47 µM -1.25716882736252 0.109850037300844 no 3025 0.104346254259585 4366 17158655 SGTC_2886 9058944 51.95 µM -1.26324262975818 0.108750488390628 no 3026 0.103250998435883 4236 4949929 SGTC_3242 9133940 49.47 µM -1.26441024634572 0.108540023265449 no 3027 0.10304140854655 4340 17248444 SGTC_3326 9140064 16.379 µM -1.26617432913682 0.108222599981516 no 3028 0.102725338003174 4284 1868434 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.26850851109401 0.107803622627451 no 3029 0.10230820662155 4178 88881 An O-methylated flavonoid and antioxidant. SGTC_2061 5245884 80.95 µM -1.27022452916505 0.107496349568933 no 3030 0.102002331269879 4317 573863 SGTC_512 prima-1 270 µM -1.27085708565745 0.107383242318196 no 3031 0.101889747897155 4348 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2626 ethyl orsellinate 100 µM -1.27501863194728 0.106641255682012 no 3032 0.101151323659843 4301 75653 A natural product. SGTC_916 4466-0038 42 nM -1.27738397924818 0.106221176942542 no 3033 0.1007333590065 4407 5722064 YGL116W CDC20 SGTC_2107 5363541 170.161 µM -1.27740238798107 0.106217912299658 no 3034 0.100730111069714 4295 244052 SGTC_3021 9087658 49.47 µM -1.27964858671797 0.105820110525402 no 3035 0.100334376975872 4347 25237042 SGTC_1946 st076057 65.1 µM -1.2797857145998 0.105795860103625 no 3036 0.100310254659347 4300 953009 SGTC_2463 5473429 200 µM -1.28123685807266 0.105539478357333 no 3037 0.100055241774599 4338 5399405 SGTC_225 nsc-122657 1.016 µM -1.28543701782382 0.104799945297144 no 3038 0.0993198062062186 4355 275685 SGTC_1104 tacrolimus 29.8 µM -1.28608059050987 0.104686962128652 no 3039 0.0992074686086279 4419 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2282 7944268 200 µM -1.28718727644049 0.104492882893983 no 3040 0.0990145104750051 4357 2970414 SGTC_2275 7947463 200 µM -1.28978300213847 0.104038694185428 no 3041 0.0985630056389165 4320 1225414 SGTC_711 k292-0785 179 µM -1.29554932673285 0.103034853672294 no 3042 0.0975653983894695 4284 4146315 SGTC_1758 st042942 75.2445 µM -1.29883593311634 0.102465856435722 no 3043 0.0970001200582237 4337 669317 SGTC_3061 glucosamine 200 µM -1.30300484536318 0.10174740057065 no 3044 0.096286553677946 4299 91431 and experimental redox chemotherapeutic SGTC_2551 apiole 73.87 µM -1.30363947027995 0.101638353940448 no 3045 0.0961782681736775 4272 10659 A possible DNA adduct former. SGTC_2011 4012611 177 µM -1.30419720238347 0.101542589962804 no 3046 0.0960831767571797 4329 2049887 SGTC_634 1611-4317 11.2 µM -1.30447141959017 0.10149553029555 no 3047 0.0960364490173437 4391 2843522 SGTC_2186 6124449 200 µM -1.30485138898405 0.101430348270023 no 3048 0.0959717282914784 4373 3834182 YLR033W RSC58 SGTC_2015 5119600 184 µM -1.30753358478872 0.100971096900786 no 3049 0.0955157782067515 4397 2828786 SGTC_3168 9103419 49.47 µM -1.31063695689891 0.100441624602235 no 3050 0.0949902235432574 4402 16649256 SGTC_1191 1487-1166 10.6 µM -1.31227951697976 0.100162205519627 no 3051 0.0947129203348547 4401 3955771 SGTC_279 1273-0055 2.93 µM -1.31362127308031 0.0999343782218038 no 3052 0.0944868430952727 4410 2847562 SGTC_3291 9121177 71.43 µM -1.31404888015895 0.0998618510461396 no 3053 0.094414877734606 4365 17015612 SGTC_1866 st057638 64 µM -1.31556831469563 0.0996044481567283 no 3054 0.0941594871079603 4361 688802 SGTC_1474 0330-0125 5.35 µM -1.31736997079114 0.0992998636335738 no 3055 0.09385732077474 4422 X1474 SGTC_80 0159-0065 512.242 µM -1.32144689040272 0.0986131425364135 no 3056 0.0931761999849804 4306 1548079 SGTC_2995 9067767 71.4286 µM -1.32254535569699 0.098428711673701 no 3057 0.0929933083301713 4391 11673567 SGTC_666 0272-0154 136 µM -1.32317489384648 0.0983231269761397 no 3058 0.0928886115380323 4375 6870312 SGTC_102 gallobenzophenone 83.616 µM -1.32998818181758 0.097185720788455 no 3059 0.0917610825895892 4383 70837 SGTC_3309 9129340 25.759 µM -1.33216407102904 0.0968245212217367 no 3060 0.0914031400445873 4398 17158987 SGTC_624 k048-0052 28 µM -1.33298484191153 0.0966885288762053 no 3061 0.091268389109823 4365 6835531 SGTC_609 0986-0026 86.3 µM -1.33307573270532 0.0966734779435275 no 3062 0.0912534760800652 4354 2848610 SGTC_2944 9067346 25.62 µM -1.33346603482417 0.0966088659758525 no 3063 0.0911894572698401 4333 6473075 SGTC_1498 4478-3555 97.6 µM -1.335458118387 0.0962795836289914 no 3064 0.0908632270051535 4377 3437919 SGTC_2226 7298446 200 µM -1.33684472013688 0.096050872082545 no 3065 0.0906366641368626 4402 3283010 SGTC_3058 9093861 49.47 µM -1.33857474692862 0.0957660751272431 no 3066 0.0903545758563016 4407 17217477 SGTC_2641 levomentholum 100 µM -1.33928168429613 0.0956498780798651 no 3067 0.0902394945174278 4395 16666 SGTC_2154 5570129 200 µM -1.34014906459055 0.0955074513061747 no 3068 0.0900984436816818 4445 673366 SGTC_758 0868-0029 16 µM -1.34196001639287 0.0952105901600063 no 3069 0.0898044801319078 4382 762687 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.34557385845865 0.0946202211995789 no 3070 0.0892199935151756 4411 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3135 9127742 49.47 µM -1.3472345876415 0.0943498258266329 no 3071 0.0889523458466341 4464 3643468 SGTC_2907 7721985 69.9 µM -1.34914970104437 0.0940387202754748 no 3072 0.0886444434986254 4403 3267881 SGTC_2687 chenodiol 100 µM -1.34989948312408 0.0939171263893069 no 3073 0.0885241137622456 4441 5702181 A cholesterol synthesis inhibitor. SGTC_920 mycophenolic acid 780.421 nM -1.35086956446742 0.0937599782989719 no 3074 0.0883686096393414 4375 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_933 2914-0560 114 µM -1.35166394878069 0.0936314368385352 no 3075 0.0882414214328138 4403 463887 SGTC_3017 9080681 49.47 µM -1.35693758908997 0.0927813927448035 no 3076 0.0874005209585267 4425 16451914 SGTC_2278 7948257 134.34 µM -1.35719381430572 0.0927402383315521 no 3077 0.0873598178438793 4409 1247028 SGTC_1359 1582-0056 520 nM -1.35973488295383 0.092332827258516 no 3078 0.0869569175989409 4463 3661189 SGTC_120 rhodamine 6G 52.259 µM -1.36119826419539 0.0920988043075379 no 3079 0.0867255212932063 4423 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_644 1498-1197 63.3 µM -1.36143414178813 0.0920611240536475 no 3080 0.0866882663901388 4432 6741615 SGTC_3199 9111318 49.47 µM -1.36205649833421 0.0919617605297285 no 3081 0.0865900277643557 4329 8548020 SGTC_115 0527-0192 112.043 µM -1.36430372404193 0.0916036365252868 no 3082 0.0862359971625292 4393 4233931 SGTC_487 nimodipine 119 µM -1.36450098197715 0.0915722503702479 no 3083 0.0862049726764601 4420 4497 L-type voltage-gated calcium channels inhibitor SGTC_3219 9131112 49.47 µM -1.36491965338159 0.0915056610265183 no 3084 0.0861391522171249 4281 17612988 YMR079W SEC14 SGTC_367 0335-0881 7.1 µM -1.36574396438488 0.0913746599352383 no 3085 0.0860096699540666 4355 23828853 SGTC_1410 3909-8106 77.9 µM -1.36598185725501 0.091336879405526 no 3086 0.0859723289820194 4464 1039210 SGTC_3190 9110366 49.47 µM -1.36601977092287 0.0913308592843754 no 3087 0.0859663789652883 4422 17123768 SGTC_185 k048-0037 25.491 µM -1.36695634287894 0.0911822390937901 no 3088 0.0858194949817271 4451 6827589 SGTC_2192 5915882 198.485 µM -1.36969262669803 0.0907490585671316 no 3089 0.0853914356551376 4379 2876149 SGTC_2286 7945697 125 µM -1.37003301913935 0.0906952780973211 no 3090 0.085338297321314 4411 1245733 SGTC_3262 9137218 49.47 µM -1.37471454205205 0.0899580168137449 no 3091 0.0846099805191399 4370 17650664 SGTC_3347 9188721 44.724 µM -1.37823041531694 0.0894072609437579 no 3092 0.0840660797077547 4431 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1229 0139-0193 12.2 µM -1.37919450902103 0.0892566763092463 no 3093 0.0839173953033594 4478 3090752 SGTC_2166 5933061 31.504 µM -1.37929157770888 0.0892415253275155 no 3094 0.0839024361312488 4481 2877375 SGTC_1413 3910-0535 34.4 µM -1.3795946294528 0.0891942357604282 no 3095 0.0838557459731456 4442 2876951 SGTC_406 estrone 100 µM -1.38367936636149 0.0885586533020922 no 3096 0.0832283271465229 4399 5870 A steroid. SGTC_1908 st060353 56.5 µM -1.38710208030096 0.0880286842179421 no 3097 0.0827053188892106 4454 4227716 SGTC_84 0443-0269 128.823 µM -1.38749043747776 0.0879687011389383 no 3098 0.0826461325065628 4366 6150058 SGTC_724 3910-0327 137 µM -1.39093895774991 0.087437401893568 no 3099 0.0821219689843435 4465 2885483 SGTC_1875 nocodazole 6 µM -1.39222105842873 0.0872404858955213 no 3100 0.0819277338926054 4464 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_858 0438-0351 2.77 µM -1.39262671966001 0.0871782499793652 no 3101 0.081866349369578 4404 2799119 SGTC_2041 5107442 45.335 µM -1.39407080584571 0.0869569695865474 no 3102 0.0816481120343449 4457 793005 SGTC_3217 9129673 49.47 µM -1.3968929989894 0.0865257306047614 no 3103 0.0812228751096739 4414 17248312 SGTC_1878 temozolomide 1 mM -1.39903797138128 0.0861990436585355 no 3104 0.0809007983628828 4380 5394 DNA alkylating agent. SGTC_2670 beta-carotene 100 µM -1.39958312963262 0.0861161613418408 no 3105 0.0808190943929551 4396 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1792 st045773 43.6 µM -1.3998612533169 0.0860739001981266 no 3106 0.0807774354407056 4399 2919270 SGTC_163 TUB2.036 7.546 µM -1.4034376423465 0.0855318465200127 no 3107 0.080243187353963 4379 15992207 YJR013W GPI14 SGTC_490 phenamil 164 µM -1.40417026576766 0.0854211229568924 no 3108 0.0801340769186278 4439 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_398 bronopol 33.3 µM -1.4059341656242 0.0851549799679442 no 3109 0.0798718374226629 4368 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_59 0330-0160 1.33 µM -1.40725808173462 0.0849556317359564 no 3110 0.0796754371892329 4394 4293482 SGTC_2598 perillyl alcohol 100 µM -1.40797110825984 0.0848484130443144 no 3111 0.0795698126539948 4457 10819 An apoptosis inducer. SGTC_608 k048-0125 159 µM -1.40879118937696 0.0847252219018333 no 3112 0.0794484605800218 4488 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_998 3996-0085 177 µM -1.40890654535885 0.0847079040953052 no 3113 0.0794314019413278 4470 715391 SGTC_542 3381-0244 89.3 µM -1.41221685676255 0.0842120742927626 no 3114 0.0789430592937987 4467 1112843 SGTC_872 0588-0139 234 µM -1.41350201623684 0.0840201668325631 no 3115 0.0787540844818945 4415 2047100 SGTC_231 b-estradiol 524 µM -1.41394359595403 0.0839543034423307 no 3116 0.0786892320797059 4428 450 A steroid. SGTC_2678 equilin 100 µM -1.41575771103669 0.0836841276576002 no 3117 0.0784232275098982 4435 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1797 st048695 56.8 µM -1.41620459549858 0.0836176736288726 no 3118 0.0783578054016049 4401 592262 YIL048W NEO1 SGTC_1192 1488-0095 21.4 µM -1.41815071424739 0.0833287379736111 no 3119 0.0780733837982877 4474 915875 SGTC_745 0469-0705 296 µM -1.41862832797155 0.0832579426255562 no 3120 0.078003701288061 4478 3486736 SGTC_3271 9137798 49.47 µM -1.42149245998581 0.0828343487252376 no 3121 0.0775868220118604 4441 6498326 SGTC_1051 3253-3903 78 µM -1.42629454939906 0.0821277799617466 no 3122 0.076891668644082 4432 5509239 SGTC_292 k038-0015 474 µM -1.42775137404303 0.0819143261712254 no 3123 0.0766817166853528 4441 46368540 SGTC_1662 st014054 52 µM -1.43572478912239 0.0807534622611934 no 3124 0.0755403342691584 4529 2838777 SGTC_110 0850-0284 111.64 µM -1.43646346924294 0.0806465484287104 no 3125 0.075435252028306 4374 3906265 SGTC_2167 5876490 200 µM -1.43691786856492 0.080580833477511 no 3126 0.0753706660190609 4489 686534 SGTC_2603 homopterocarpin 100 µM -1.4369876405505 0.0805707466788072 no 3127 0.0753607527176319 4437 101795 A weak amylase inhibitor. SGTC_2859 9028643 45.46 µM -1.43836958357193 0.08037115836023 no 3128 0.0751646090418643 4292 17151580 SGTC_610 4215-0184 155 µM -1.4388724049962 0.0802986307080527 no 3129 0.0750933386213935 4472 5605015 SGTC_1600 coumarin 106 71.1 µM -1.44556523218593 0.0793379533003229 no 3130 0.0741495921275992 4529 100336 A hepatotoxic, DNA x-linker. SGTC_874 0599-0792 117 µM -1.44838527962054 0.0789357834272381 no 3131 0.073754664661389 4467 765305 SGTC_2766 oltipraz 83.91 µM -1.44907981102602 0.0788369729891263 no 3132 0.0736576476948098 4439 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_427 1354-0053 47.3 µM -1.45062026582605 0.078618148153568 no 3133 0.0734428144792925 4490 6813657 SGTC_2829 7992743 58.44 µM -1.46181863836086 0.077041211457995 no 3134 0.0718954576034985 4445 16462845 SGTC_2753 fluvastatin 17.09 µM -1.46343783703031 0.0768152018551378 no 3135 0.0716738058288361 4458 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_3049 9092223 49.47 µM -1.46602196363185 0.0764555512205581 no 3136 0.0713211516888802 4466 8623917 SGTC_535 2293-4129 48.2 µM -1.46905799459939 0.0760346443040196 no 3137 0.070908529881295 4478 396118 YIL048W NEO1 SGTC_1759 st043059 70 µM -1.4719485766017 0.0756355436451564 no 3138 0.0705173822506504 4481 669426 SGTC_780 0109-0199 192 µM -1.47457364886089 0.0752744863729033 no 3139 0.0701636018612544 4515 610414 SGTC_1837 st055472 66.5 µM -1.47666704389971 0.0749874998576918 no 3140 0.069882455209385 4524 676091 SGTC_1571 st070080 73.4 µM -1.48450117447195 0.0739209094293548 no 3141 0.0688380059044088 4483 4315245 SGTC_3 0833-0587 95.581 µM -1.4855246183883 0.0737824314525982 no 3142 0.0687024534780659 4369 5382644 SGTC_2126 5251174 33.877 µM -1.48647251647202 0.0736543522157707 no 3143 0.0685770905906616 4467 790722 SGTC_1451 4152-0210 104 µM -1.48950199582793 0.0732461509565081 no 3144 0.0681776140875048 4519 659563 SGTC_2743 auranofin 4.32 µM -1.49105910185424 0.0730370162849585 no 3145 0.0679729893405485 4542 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2439 5492030 7.2 µM -1.49397103261732 0.0726471421430308 no 3146 0.0675915953563224 4499 5722370 SGTC_871 0574-0004 149 µM -1.49506936355397 0.0725005028891717 no 3147 0.0674481702210399 4450 9551173 SGTC_2531 methyl deoxycholate 70.07 µM -1.49600672430047 0.0723755343479146 no 3148 0.0673259514429978 4433 16667744 Haematoxylin. SGTC_1795 st049545 62.3 µM -1.49731416910531 0.0722015020950663 no 3149 0.0671557648757768 4438 5291882 SGTC_987 1497-1013 404 µM -1.50048517760797 0.071780745740346 no 3150 0.0667443850945912 4507 1676435 SGTC_1976 st070609 63.5 µM -1.50673780619511 0.0709566072783158 no 3151 0.0659389384273752 4442 682556 SGTC_2474 5321570 43.32 µM -1.5167495941748 0.0696521482465662 no 3152 0.0646649588530726 4504 2841384 SGTC_439 amiodarone 34.4 µM -1.52044743108882 0.0691750448297915 no 3153 0.0641992806708202 4376 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2702 st077768 96.8 µM -1.52387065067706 0.068735621386182 no 3154 0.0637705131664167 4474 6484119 SGTC_1213 1315-0166 115 µM -1.52470706941019 0.0686285819502645 no 3155 0.0636660888456786 4502 768401 SGTC_1092 toremifene 6.32 µM -1.52497135163214 0.0685947875695209 no 3156 0.0636331216922091 4503 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_206 4546-0025 72.014 µM -1.52814259869078 0.0681902732673279 no 3157 0.0632385684436683 4537 6620745 YIL048W NEO1 SGTC_1428 4049-0204 61.7 µM -1.53249027126217 0.0676386933894556 no 3158 0.0627007482628478 4544 X1428 SGTC_2363 9053361 176 µM -1.53324722676043 0.0675430133770416 no 3159 0.0626074760103349 4539 6469797 YMR079W SEC14 SGTC_1744 st037937 38.9 µM -1.5347016403743 0.0673594674549496 no 3160 0.0624285663677281 4537 1016152 SGTC_497 capsazepine 133 µM -1.53850342309689 0.066881506337279 no 3161 0.0619627861023113 4464 2733484 A calcium channel blocker. SGTC_561 1550-0330 72.9 µM -1.53873922323483 0.0668519481167264 no 3162 0.061933986307716 4475 6812934 SGTC_3203 9113543 49.47 µM -1.53989054975476 0.0667077711728276 no 3163 0.0617935173623773 4527 17018012 SGTC_1579 chlormadinone acetate 49.4 µM -1.53997601873786 0.0666970777668321 no 3164 0.0617830995429471 4534 45114258 A steroidal progestin. SGTC_1839 st053978 48 µM -1.54242830248149 0.0663908263267711 no 3165 0.0614847741626304 4551 3788398 SGTC_500 h-89 112 µM -1.54329336278692 0.066283054150622 no 3166 0.0613798066438701 4482 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_671 0560-0003 407 µM -1.54543173276304 0.0660172300990765 no 3167 0.0611209348290848 4472 3238678 SGTC_1985 st071382 65.5 µM -1.55944276425667 0.0642958861567363 no 3168 0.0594458106854108 4509 6123237 SGTC_945 3381-0768 11.3 µM -1.56166773228186 0.0640257734978663 no 3169 0.0591831420634416 4526 1126236 YIL048W NEO1 SGTC_1717 st033143 58.0435 µM -1.56308206990491 0.0638545311527626 no 3170 0.0590166461923812 4545 674616 SGTC_2118 5526350 200 µM -1.5644572683939 0.0636883693926745 no 3171 0.0588551103347131 4533 743594 SGTC_127 0180-0333 59.125 µM -1.56522772748013 0.063595423903829 no 3172 0.0587647611463254 4435 771601 SGTC_2084 5306078 60.6385 µM -1.5655177721785 0.0635604612845434 no 3173 0.0587307767804266 4467 679340 SGTC_552 k242-0005 476 µM -1.56560714109266 0.0635496915760073 no 3174 0.0587203085869229 4569 4088318 SGTC_2707 st078556 66.6 µM -1.56930369202319 0.0631054689119129 no 3175 0.0582885962249169 4453 17250899 SGTC_1404 3909-7820 48.3 µM -1.57016566722949 0.0630022319741194 no 3176 0.0581882873136489 4530 23741373 SGTC_907 3448-6986 75.5 µM -1.57387865997421 0.0625590378934694 no 3177 0.0577577521632732 4539 590582 SGTC_2303 7774051 200 µM -1.57489870631329 0.0624377086135066 no 3178 0.0576399136678846 4528 2953184 SGTC_496 calpeptin 138 µM -1.57511781900691 0.0624116702371249 no 3179 0.0576146258661075 4518 73364 A calpain inhibitor. SGTC_2671 danthron 100 µM -1.58038943387188 0.0617877639680882 no 3180 0.0570088549072202 4530 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1961 st076550 68.7 µM -1.58129755697752 0.0616807790614363 no 3181 0.0569050089741376 4535 1579337 SGTC_541 4513-1321 94 µM -1.58432466349764 0.0613252035752224 no 3182 0.056559928021587 4509 747515 SGTC_3073 9114972 49.47 µM -1.58512653149657 0.061231281905163 no 3183 0.0564687942994377 4556 41905075 SGTC_1739 st037196 92.5 µM -1.58655630546942 0.0610640934158698 no 3184 0.0563065851183859 4545 612214 SGTC_1626 st003712 1.76 µM -1.58819752731668 0.0608726196859887 no 3185 0.0561208400428025 4532 24207035 SGTC_3108 9121785 49.47 µM -1.59618340925155 0.0599476355117027 no 3186 0.0552239253042916 4412 17140271 SGTC_2346 9031566 143.75 µM -1.5964678741136 0.0599148908539884 no 3187 0.0551921863923848 4519 4771086 SGTC_904 1141-0088 396 µM -1.59652745950897 0.0599080337733265 no 3188 0.0551855400308529 4553 1378119 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.60968038918433 0.0584093814559026 no 3189 0.0537338241688009 4552 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1090 efavirenz 20.7 µM -1.6171270711235 0.057574048741902 no 3190 0.0529254272230493 4575 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2767 sibutramine 71.45 µM -1.62437205219625 0.0567703878051576 no 3191 0.0521482140270486 4546 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1200 1643-0193 18.4 µM -1.62507093829656 0.0566933323879633 no 3192 0.0520737222075522 4577 5403974 SGTC_1433 4060-0023 7.6 µM -1.62830113277402 0.0563382584485986 no 3193 0.0517305247095124 4576 3840627 SGTC_1798 st045719 60.953 µM -1.62906535488515 0.0562545095245201 no 3194 0.0516495922138012 4536 3980186 SGTC_570 0987-0065 62.6 µM -1.63029460146888 0.0561200058369514 no 3195 0.0515196240037414 4443 3104428 SGTC_603 3794-0023 45.9 µM -1.63375651429683 0.0557425672565585 no 3196 0.0511549932738847 4597 3802260 SGTC_839 0122-0028 230 µM -1.63429546421071 0.0556839883122859 no 3197 0.0510984128157671 4574 759448 SGTC_1813 st051246 8.6015 µM -1.63603009801452 0.0554957791942578 no 3198 0.0509166441843687 4522 5291959 SGTC_576 1073-0113 22.7 µM -1.63768080396067 0.0553171430085278 no 3199 0.0507441485211686 4625 5439563 SGTC_493 zm226600 134 µM -1.63870333813018 0.0552067143211759 no 3200 0.0506375292565346 4566 5240098 A potassium channel opener. YCR052W RSC6 SGTC_564 3555-0129 330 µM -1.6415194715213 0.0549034857136289 no 3201 0.0503448142679869 4471 563260 SGTC_1726 st035556 14.5795 µM -1.64335163703043 0.0547069141443171 no 3202 0.0501551001467838 4597 5919439 SGTC_706 4262-0057 46.9 µM -1.64419182385807 0.0546169574534106 no 3203 0.0500682926447488 4553 883298 SGTC_3179 9107801 49.47 µM -1.64624408905631 0.0543977183372745 no 3204 0.0498567577142144 4551 4818259 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.64691272584377 0.0543264398399051 no 3205 0.0497879928949108 4510 4000243 SGTC_2032 5185112 25.99 µM -1.64743802864913 0.0542704929797107 no 3206 0.0497340221038881 4452 5718189 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.64761837227806 0.0542512961735508 no 3207 0.0497155039607068 4546 5282362 SGTC_562 3772-2733 112 µM -1.6496926856554 0.0540308805092868 no 3208 0.0495029034807131 4545 2876874 YIL048W NEO1 SGTC_1208 2323-2347 50.3 µM -1.6506985431372 0.0539242540286679 no 3209 0.049400072731106 4582 5412760 SGTC_1903 st060211 78.3 µM -1.65645685102702 0.0533170446258246 no 3210 0.0488146681474622 4590 688960 SGTC_1889 st059080 5.18 µM -1.65813600162801 0.0531410036960422 no 3211 0.0486450093579571 4546 176925 Isolated from Daphnopsis sellowiana. SGTC_1088 bifonazole 369 nM -1.6604724564782 0.0528968185723441 no 3212 0.0484097222177277 4579 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1180 1193-0155 285 µM -1.6641341104382 0.0525159269165384 no 3213 0.0480428158910912 4623 2921347 SGTC_1301 naphtanilide LB 4.81 µM -1.66506871652348 0.0524190571264302 no 3214 0.0479495235757212 4612 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_669 0108-0021 26.2 µM -1.66570468232441 0.0523532218653961 no 3215 0.0478861244635878 4573 17201 SGTC_2794 7785382 27.27 µM -1.66657360881964 0.0522633766315458 no 3216 0.0477996101190767 4561 2205081 SGTC_2497 7-hydroxyflavone 100 µM -1.66878895918634 0.0520348678863261 no 3217 0.0475796057847621 4577 5281894 SGTC_418 lividomycin a 100 µM -1.66887063049534 0.0520264588565536 no 3218 0.0475715106131199 4594 72394 An antibiotic. SGTC_2462 5162487 171.77 µM -1.67148905566343 0.0517574326448124 no 3219 0.0473125593271265 4553 2259986 SGTC_1968 st069590 43.6 µM -1.67152901877471 0.0517533352773303 no 3220 0.0473086159123331 4538 6384066 SGTC_1421 4029-0249 71.4 µM -1.69238392500015 0.0496500432263552 no 3221 0.0452863976576067 4662 2894095 SGTC_2014 4013930 200 µM -1.69351678557154 0.0495377726292561 no 3222 0.0451785712813909 4553 64556 SGTC_3059 1327-0034 3 µM -1.6941393593562 0.0494761596310674 no 3223 0.0451194023333272 4442 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_973 1325-0077 65.9 µM -1.69486774332236 0.0494041527916189 no 3224 0.0450502564377756 4597 2835149 SGTC_3264 9137442 49.47 µM -1.69581237446853 0.0493108927426967 no 3225 0.0449607091260174 4549 17015726 SGTC_3126 9127922 49.47 µM -1.70779431623713 0.0481401167583302 no 3226 0.0438372570453791 4543 45595682 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.71036877138715 0.0478914885882891 no 3227 0.0435988509902101 4599 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_822 1487-0950 154 µM -1.71205586127029 0.0477291160685857 no 3228 0.0434431872357754 4583 1958375 SGTC_712 r015-0009 80.6 µM -1.7126662877428 0.0476704748190838 no 3229 0.0433869752996904 4625 6813872 YLR060W FRS1 SGTC_452 diindolylmethane 8 µM -1.71509008620251 0.0474381993211225 no 3230 0.0431643558252675 4583 3071 Inhibits expression of several cancer promoting factors. SGTC_79 0052-0007 94.094 µM -1.71543808565194 0.0474049246875586 no 3231 0.0431324688721799 4589 2801472 SGTC_1325 1431-0015 227 µM -1.71543943963243 0.0474047952606543 no 3232 0.0431323448450367 4593 1103340 SGTC_3018 9082602 49.47 µM -1.71600014101706 0.0473512221848022 no 3233 0.043081008305752 4485 17332089 SGTC_3263 9137018 49.47 µM -1.71629810012295 0.0473227729715021 no 3234 0.043053747940622 4553 43844957 SGTC_287 k060-0039 29.6 µM -1.73652687683467 0.0454231399579572 no 3235 0.0412353581598261 4641 5861974 SGTC_2366 9070441 60.58 µM -1.73754364992765 0.0453293001217982 no 3236 0.0411456281691278 4570 6837235 SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.75707135105756 0.0435571237961681 no 3237 0.0394528241033686 4638 77254 SGTC_851 0394-0702 453 µM -1.76497030777636 0.0428563514001571 no 3238 0.0387843780352607 4622 762646 SGTC_2625 euphol 100 µM -1.77244246291181 0.0422018573964039 no 3239 0.0381605691666087 4609 6708538 A triterpene alcohol. SGTC_604 1000-0114 314 µM -1.77434470927235 0.0420365356756683 no 3240 0.038003074728128 4628 1572745 SGTC_1935 st074532 41.6 µM -1.77646464176004 0.0418529131893167 no 3241 0.0378281824010745 4571 2829742 SGTC_1948 st076329 66.6 µM -1.78389783555611 0.0412141964441088 no 3242 0.0372201338479746 4542 24208413 SGTC_2646 retinol 96.75 µM -1.79320847375631 0.0404253283303973 no 3243 0.0364697978274061 4641 445354 A vitamin A analog and teratogen. SGTC_2079 5212404 121 µM -1.79330103419728 0.0404175478908343 no 3244 0.0364624010678367 4582 758462 SGTC_797 k781-0471 270 µM -1.80009042457896 0.0398501530392531 no 3245 0.0359231806590707 4600 23738129 SGTC_1657 st012939 43.4 µM -1.80202425602376 0.0396897312458749 no 3246 0.035770794691387 4627 24207257 SGTC_3230 9131665 49.47 µM -1.80215014707974 0.0396793061320603 no 3247 0.0357608928649852 4645 15943720 SGTC_826 1683-5028 118 µM -1.80536322863598 0.0394139817083774 no 3248 0.0355089306631149 4653 722377 SGTC_193 1273-0060 1.558 µM -1.80720518444697 0.0392625318395756 no 3249 0.0353651464441824 4507 2847393 YHR072W ERG7 SGTC_1079 idarubicin 2.36 µM -1.80873530090903 0.0391370825369114 no 3250 0.0352460679822989 4647 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1116 jasmonic acid  1.58368 µM -1.81482708095369 0.0386408686981599 no 3251 0.0347752436476069 4675 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_3330 9141424 71.43 µM -1.8177227724956 0.0384068003472242 no 3252 0.0345532576732514 4632 27261020 SGTC_1247 0448-0043 5.84 µM -1.8203294748793 0.0381970817051299 no 3253 0.0343544226706567 4593 3089013 YGL099W LSG1 SGTC_761 k216-0224 480 µM -1.82272934080102 0.0380048303723905 no 3254 0.0341721970706273 4637 1340404 SGTC_2806 7952793 58.44 µM -1.82439733058038 0.0378716746148175 no 3255 0.0340460126399655 4631 2972490 SGTC_3324 9138759 60.749 µM -1.83414846338798 0.0371008399927422 no 3256 0.033315979566664 4636 45595710 SGTC_2738 aclarubicin 5.55 µM -1.83753013541745 0.0368365294468674 no 3257 0.0330658359601406 4681 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2115 tiliquinol 12.7705 µM -1.84532721294515 0.0362329771453073 no 3258 0.0324949770945332 4612 71208 A bioactive hydroxyquinoline. SGTC_651 3253-0966 34.4 µM -1.8472973300215 0.0360817633759071 no 3259 0.0323520298555473 4651 781462 SGTC_2398 5228213 48.84 µM -1.84944010978709 0.0359178842406898 no 3260 0.032197144114939 4596 80771 YMR134W ERG29 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.85051067351906 0.035836236563765 no 3261 0.0321199905528546 4629 6312947 SGTC_503 tyrphostin 8 294 µM -1.86044209376175 0.0350860322693351 no 3262 0.0314115019497667 4654 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2255 7941087 197.44 µM -1.86203642462121 0.0349668080316425 no 3263 0.0312989780837909 4693 935561 SGTC_2443 5493264 126.67 µM -1.86602021297118 0.0346703528718639 no 3264 0.031019268795185 4658 5340055 SGTC_2741 miltefosine 3.04 µM -1.86912803491673 0.0344405190385145 no 3265 0.0308025017321933 4693 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_632 0781-2353 4.65 µM -1.87081234985535 0.0343164823137098 no 3266 0.0306855476149906 4677 6811515 YHR007C ERG11 SGTC_1173 0443-0020 122 µM -1.8733705677145 0.0341287919025193 no 3267 0.0305086156852171 4639 5331295 SGTC_1625 st003711 30.1 µM -1.89157019706323 0.0328177554406396 no 3268 0.0292741349432887 4647 24207034 YER133W GLC7 SGTC_2212 7123476 200 µM -1.90090627747785 0.0321614991182648 no 3269 0.0286571448578144 4703 1085715 SGTC_3071 9117417 49.47 µM -1.90687484393072 0.0317476583456267 no 3270 0.0282683982328578 4628 45595590 YGL055W OLE1 SGTC_715 0868-0130 184 µM -1.90747600725251 0.0317062206496372 no 3271 0.0282294875396617 4700 2876258 SGTC_2444 5485484 36.41 µM -1.93965762232842 0.0295523399410971 no 3272 0.0262106564879879 4690 6790631 SGTC_2027 5150920 200 µM -1.94441603888881 0.029244417047601 no 3273 0.025922650638019 4641 786715 SGTC_1203 3992-3522 103 µM -1.96103560032425 0.0281897809192905 no 3274 0.0249374350791075 4662 5322312 SGTC_1906 st060206 94.7 µM -1.97643823583714 0.0272408247799332 no 3275 0.0240525823002896 4685 5133468 SGTC_2502 avocadyne acetate 18.59 µM -1.98363349047614 0.0268067427244692 no 3276 0.0236483564460371 4654 3952079 SGTC_1018 4259-0013 28.1 µM -1.99418975680363 0.0261803588053237 no 3277 0.023065660571282 4700 6801262 SGTC_2898 9056270 58.44 µM -1.99838184737175 0.0259350281620607 no 3278 0.0228376390578695 4700 19154699 SGTC_1261 0712-0010 12.7 µM -2.00394933272156 0.0256121823759371 no 3279 0.0225377441051369 4670 2840123 SGTC_2331 7980721 200 µM -2.00609701113637 0.0254885459669646 no 3280 0.0224229493474743 4647 2981221 SGTC_2022 5136654 200 µM -2.00845138305523 0.0253535854133758 no 3281 0.0222976736880048 4648 1713771 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -2.00972917332438 0.0252805891135565 no 3282 0.0222299302693623 4632 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_592 k241-0073 46.5 µM -2.01481926365336 0.0249915531650474 no 3283 0.0219617949304108 4718 4230158 SGTC_1886 st057356 49.9 µM -2.02212747485606 0.0245814118718198 no 3284 0.0215815921457214 4684 24207747 SGTC_1320 1313-0481 95.3 µM -2.02243842868329 0.0245640869767466 no 3285 0.0215655392099591 4657 6813365 YLR208W SEC13 SGTC_875 0709-0210 25.7 µM -2.03963506412627 0.0236217995275066 no 3286 0.0206933434708063 4684 6251364 SGTC_2742 clothiapine 36.27 µM -2.0440354690588 0.0233856247659383 no 3287 0.0204750216445291 4717 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3207 9114163 49.47 µM -2.04727677226214 0.0232129339021726 no 3288 0.0203154585964187 4657 849233 SGTC_1245 0418-0076 17.2 µM -2.06598140332803 0.0222372258796253 no 3289 0.0194151177881431 4685 6790114 SGTC_3327 9140648 26.9345 µM -2.06963818697148 0.0220505740451843 no 3290 0.0192431196122256 4717 8029710 SGTC_1169 aniline yellow 25.8 µM -2.07515058409638 0.0217717072445778 no 3291 0.018986290417699 4675 6051 A DNA damaging agent. SGTC_1375 2910-0797 186 µM -2.07756844025123 0.0216503334347467 no 3292 0.0188745627466855 4704 742508 SGTC_446 go6976 132 µM -2.07873903437226 0.0215917765598876 no 3293 0.0188206715642697 4707 3501 A protein kinase C inhibitor. SGTC_2415 st077333 57.7 µM -2.07965015566386 0.02154629202528 no 3294 0.0187788165113142 4678 2766255 SGTC_194 1486-1323 56.904 µM -2.08536080523804 0.0212630484976477 no 3295 0.0185182809093049 4757 5178754 SGTC_3150 9097574 49.47 µM -2.09447082875987 0.0208177198426265 no 3296 0.0181090295148372 4713 17217476 SGTC_1296 1068-0102 11.9 µM -2.09692422157045 0.0206991482221728 no 3297 0.0180001419945783 4712 767053 SGTC_2747 doxorubicin 7.63 µM -2.09733077963209 0.020679554759289 no 3298 0.017982151988872 4758 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1997 st073024 93.8 µM -2.11372379166007 0.0199025012053225 no 3299 0.0172694326133565 4731 686268 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.12384683931942 0.0194351378476858 no 3300 0.0168414764328932 4712 616764 SGTC_2744 captopril 92.04 µM -2.12817051333853 0.0192383814449515 no 3301 0.0166614743270767 4745 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1607 st000305 50.6 µM -2.14345458309162 0.0185563680946936 no 3302 0.0160383071121957 4717 5457690 SGTC_2102 5377816 72.7585 µM -2.14612351831263 0.0184394097991309 no 3303 0.015931562692361 4717 1379702 SGTC_1891 st059073 26.2 µM -2.15000693939613 0.0182703519198348 no 3304 0.0157773329397323 4736 688754 SGTC_25 0118-0223 35.662 µM -2.15535701044983 0.0180396102959612 no 3305 0.0155669538528117 4700 5333628 SGTC_443 clozapine 122 µM -2.18086194708145 0.0169734740412737 no 3306 0.0145968145080618 4717 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_334 1502-1024 68.5 µM -2.19106681591904 0.0165622418258608 no 3307 0.0142234788339172 4718 3296216 SGTC_26 0302-0163 425.158 µM -2.21776113487712 0.0155266376281601 no 3308 0.0132855616905317 4753 3100915 SGTC_65 0798-0905 34.986 µM -2.23278613957435 0.0149685646911193 no 3309 0.0127815253700322 4681 3602145 SGTC_786 4544-0069 423 µM -2.27538774522151 0.0134790312210425 no 3310 0.0114413399342402 4715 748821 YLR208W SEC13 SGTC_588 3970-1144 52.9 µM -2.27733402305311 0.013414151640279 no 3311 0.0113831433471143 4681 1888707 SGTC_522 1273-0010 11.6 µM -2.31073349629671 0.0123420749064721 no 3312 0.0104237899286545 4736 5705015 SGTC_792 4534-1957 155 µM -2.31334910380942 0.012261342157132 no 3313 0.0103517264854313 4719 1717904 SGTC_2473 5854593 8.94 µM -2.34015299213643 0.0114600451016014 no 3314 0.00963792091925796 4740 2872951 SGTC_2787 5284540 71.43 µM -2.35296158421329 0.0110934706279012 no 3315 0.00931227905609338 4742 736958 SGTC_150 3970-0969 77.2 µM -2.35976269255347 0.0109030040924815 no 3316 0.00914331435123183 4740 6615640 SGTC_2215 7188065 200 µM -2.35988652836957 0.0108995625880159 no 3317 0.00914026285512197 4763 940217 SGTC_2397 5161689 200 µM -2.39750842735999 0.00989681681864957 no 3318 0.00825350062712898 4732 2259942 SGTC_2393 9031399 185.94 µM -2.39891042685324 0.00986105927672305 no 3319 0.00822196832975718 4725 1526623 YDL150W RPC53 SGTC_1925 st057770 10.1 µM -2.40838249637775 0.00962241994830639 no 3320 0.00801169171701646 4731 5989122 SGTC_2629 bisabolol 100 µM -2.41393328019405 0.00948493197550484 no 3321 0.0078906759442682 4742 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2827 7993847 71.43 µM -2.4543854707237 0.00853382645616311 no 3322 0.00705628056640695 4747 2985692 SGTC_1882 5615643 20 µM -2.47480762137333 0.00808625619529061 no 3323 0.00666539807506011 4765 2253075 SGTC_2329 6138490 200 µM -2.52520337123696 0.00706894657506837 no 3324 0.00578156759584067 4732 720019 SGTC_3004 9076122 71.4286 µM -2.54127802506983 0.00676911754984552 no 3325 0.00552240268320823 4763 44782551 SGTC_1251 0490-5699 265 µM -2.54262035158543 0.00674459594828037 no 3326 0.00550123514837854 4760 3883818 SGTC_713 1488-1073 324 µM -2.54991058246685 0.00661278405608348 no 3327 0.00538752755408102 4767 3312542 SGTC_66 0109-0187 42.4 µM -2.55347622363569 0.00654914838710496 no 3328 0.00533267800628188 4652 759417 SGTC_2739 tacrine 100.86 µM -2.56304247146604 0.00638108822096319 no 3329 0.00518796775221918 4781 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_946 3434-1334 87.4 µM -2.60009359506567 0.00576563853613386 no 3330 0.00465991687949419 4747 4047976 SGTC_776 4476-4378 112 µM -2.64082805699665 0.00515031898014391 no 3331 0.00413518402385316 4774 2892008 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -2.6964676759326 0.00440444177441572 no 3332 0.00350395993827733 4762 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_154 3389-1638 511.116 µM -2.69654040371849 0.00440353355155771 no 3333 0.00350319486375826 4768 5238686 SGTC_366 0181-0206 4.31 µM -2.71192330712157 0.00421515160977956 no 3334 0.00334470339807256 4752 274874 SGTC_2358 9037157 4 µM -2.77491380837121 0.00351673994811368 no 3335 0.00276081696417945 4764 2388925 SGTC_939 1165-0479 45.3 µM -2.78775981264168 0.00338777319597734 no 3336 0.00265369386381253 4761 1377347 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.82587512203187 0.00302975565398431 no 3337 0.00235758211611231 4792 5393153 SGTC_3148 9097893 49.47 µM -2.83150985272121 0.00297982380486232 no 3338 0.00231644031069436 4766 17174100 SGTC_2205 7238770 200 µM -2.83707807811672 0.00293121096890018 no 3339 0.00227642384173544 4776 279867 SGTC_813 k007-0158 173 µM -2.8728073053586 0.0026359287006495 no 3340 0.00203421091561722 4782 6523916 SGTC_720 r052-1644 49.9 µM -2.91234477362317 0.00234070995040593 no 3341 0.00179363222930214 4788 1422863 YOR257W CDC31 SGTC_2746 daunorubicin 9.88 µM -2.92972294217658 0.00222069081736745 no 3342 0.0016963217325183 4798 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_517 1365-0151 113 µM -2.93347918707417 0.00219549358745337 no 3343 0.001675930631721 4769 768657 SGTC_2572 astragaloside iv 100 µM -2.99447736540918 0.00182100032133839 no 3344 0.00137457726308162 4772 45006101 An anti-inflammatory agent. SGTC_2101 5377231 179.231 µM -3.04701947369923 0.001546055272825 no 3345 0.00115561367932884 4793 2844213 SGTC_2985 9022375 71.43 µM -3.10536126826826 0.00128550525044092 no 3346 0.000950233742949875 4779 4939335 SGTC_2336 9001819 198.65 µM -3.1467017911472 0.00112590343139831 no 3347 0.000825616384465826 4777 2989602 SGTC_2360 9040895 200 µM -3.17644046869136 0.00102255326830576 no 3348 0.000745471932375496 4792 4914414 SGTC_1729 st035615 45.989 µM -3.33099947952651 0.000612298105333513 yes 3349 0.000432673820992367 4789 17385451 SGTC_3069 9117009 49.47 µM -3.54512538460438 0.000290656982673155 yes 3350 0.000196213182614051 4802 41904981 SGTC_3194 9111903 49.47 µM -3.55757983638024 0.000277984804813347 yes 3351 0.000187143681641279 4800 17087251 SGTC_3075 9116269 49.47 µM -3.5644205313413 0.000271245380913572 yes 3352 0.000182330454921677 4796 17015205 YNL244C SUI1 SGTC_2770 toltrazuril 17.5 µM -3.61047741905821 0.000229685337445965 yes 3353 0.000152816955481471 4803 68591 Kills coccidiodes. SGTC_2576 guaiol 23.12 µM -3.67479465377224 0.000181512717486302 yes 3354 0.000119020394002242 4793 227829 SGTC_2362 9071156 126 µM -3.82242149606866 0.00010429438855912 yes 3355 6.60737779852415e-05 4801 653133 SGTC_2207 7258803 200 µM -3.92053184322943 7.13990072002385e-05 yes 3356 4.41768798479391e-05 4789 3666799