SGTCid condition conc unit RPL40B|YKR094C.score RPL40B|YKR094C.strain.pval RPL40B|YKR094C.strain.significant RPL40B|YKR094C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1680 diphenhydramine 100 µM 8.71468889010321 2.45850423148118e-18 yes 1 1.45779104700089e-18 2 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2023 5144124 124 µM 5.56162124898471 1.54965141526845e-08 yes 2 1.33639939573392e-08 2 2830192
SGTC_454 lyso-paf C-16 6.67 µM 5.12115407989076 1.69873534636135e-07 yes 3 1.51835693449772e-07 4 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1365 1672-3266 55.4 µM 4.94710707615787 4.15907414102906e-07 yes 4 3.76622732570008e-07 3 6415873
SGTC_1204 4049-0315 18.3 µM 4.19155280830935 1.45607847580219e-05 yes 5 1.38525840714849e-05 21 588402
SGTC_1761 st044296 37 µM 4.11381815750173 2.03631033100008e-05 yes 6 1.94584019992257e-05 12 1826700
SGTC_1676 st018489 23.4 µM 4.06748173211408 2.48028624172789e-05 yes 7 2.37619664147333e-05 31 3696235
SGTC_1378 2093-0007 380 nM 3.86104976499624 5.82826455889863e-05 yes 8 5.64504514456978e-05 24 3618014
SGTC_1374 2889-5571 141 µM 3.72102385345021 0.000101721597338829 yes 9 9.92083466882653e-05 46 2853281
SGTC_140 0062-0056 502.533 µM 3.6620096620857 0.000127933302675853 yes 10 0.000125122209488692 30 3758964
SGTC_2691 st077356 60.2 µM 3.5978900614789 0.000163523273484395 yes 11 0.00016040458044786 46 2839272
SGTC_2765 myclobutanil 7.74 µM 3.5368791212592 0.00020581343213275 yes 12 0.000202442464948732 68 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_808 0711-0032 135 µM 3.51920338481751 0.000219854494117571 yes 13 0.000216422372052382 25 4252555
SGTC_1336 1486-0901 104 µM 3.4165082537227 0.000320760505975304 yes 14 0.000317148704950152 35 5006114
SGTC_2806 7952793 58.44 µM 3.37568380208549 0.000371724774406874 yes 15 0.000368162451860328 44 2972490
SGTC_523 1934-0222 13.7 µM 3.31512487521193 0.0004613099214098 yes 16 0.000458010970894552 53 1361595
SGTC_1040 k898-0338 155 µM 3.2988591482313 0.00048857336199014 yes 17 0.000485393041719115 40 20969351
SGTC_526 4469-0568 170 µM 3.13813863696105 0.000850485351974183 yes 18 0.000850122190292444 63 2901964
SGTC_2796 7949634 45.45 µM 3.13185924265432 0.000868688515426016 yes 19 0.000868515658292321 60 2971588
SGTC_1632 st005650 90 µM 3.12514531155835 0.000888547126641396 yes 20 0.000888586229783087 63 2759605
SGTC_2791 5663188 71.43 µM 3.07662877035062 0.00104492428959306 no 21 0.00104677926955446 59 54690634
SGTC_3123 9126162 49.47 µM 3.01430975168862 0.00128277560462289 no 22 0.00128782346285117 49 25239884
SGTC_2212 7123476 200 µM 3.00594315970822 0.00131823001736224 no 23 0.00132379241936969 13 1085715
SGTC_3227 9130768 49.47 µM 2.98400964912894 0.00141546933922496 no 24 0.00142248899901398 27 17720899
SGTC_1497 4476-2978 41.3 µM 2.95762382804095 0.00154110528391502 no 25 0.00155010100810333 73 1528379
SGTC_3023 9089636 49.47 µM 2.95654321624803 0.0015464609879417 no 26 0.00155554315155317 28 17249241
SGTC_1953 st076800 12.1 µM 2.949107739842 0.00158377506917436 no 27 0.00159346426460642 110 297591
SGTC_1247 0448-0043 5.84 µM 2.94760320147862 0.00159142452663343 no 28 0.00160123918793326 115 3089013 YGL099W LSG1
SGTC_2018 5133068 143 µM 2.94175586519982 0.00162147468269069 no 29 0.00163178553535761 76 785362
SGTC_1114 scopoletin 1.73284 µM 2.92126931445358 0.00173088117969968 no 30 0.00174304167556515 49 5280460 A coumarin with genotoxic properties.
SGTC_906 1165-0455 526 µM 2.91933599106472 0.00174154532602954 no 31 0.00175388960917917 42 3252859
SGTC_1752 st044819 83.042 µM 2.91061565658209 0.00179039339244286 no 32 0.00180358718067767 71 441209 YML126C ERG13
SGTC_446 go6976 132 µM 2.89920734010946 0.00185617986667084 no 33 0.00187053706079221 59 3501 A protein kinase C inhibitor.
SGTC_963 1269-2853 151 µM 2.88137977384594 0.00196339264020223 no 34 0.00197969126812812 76 3668223
SGTC_2343 7990716 14.84 µM 2.86907663931825 0.00204062972377858 no 35 0.00205836017765547 63 6456862
SGTC_2210 7115885 190.385 µM 2.79771002576018 0.00254561720541762 no 36 0.00257331473101337 87 2927039
SGTC_1254 0550-0035 264 µM 2.77108863009731 0.00276122723584136 no 37 0.00279346086446388 83 15121435
SGTC_234 nsc-17383 10.7 µM 2.76459690911898 0.00281624383222299 no 38 0.00284965876013984 88 408974
SGTC_1483 3453-0561 55.9 µM 2.75002805440181 0.00294332943093016 no 39 0.00297950813043906 85 4546991
SGTC_2051 5263410 176 µM 2.72111521614684 0.00321095453196239 no 40 0.00325310402767879 68 227584
SGTC_2352 9027995 87.8 µM 2.67757561082869 0.00365538381990255 no 41 0.00370785563752487 89 2997347
SGTC_2149 5554786 194.827 µM 2.67627920007478 0.00366942447957385 no 42 0.00372223000376397 126 745063 YPR165W RHO1
SGTC_2072 5231554 129 µM 2.66279004592596 0.00381841413108858 no 43 0.00387478750878851 61 789545
SGTC_2786 7743617 45.45 µM 2.6625649651009 0.00382094552516145 no 44 0.00387737993783151 92 583674
SGTC_804 1595-0054 20.9 µM 2.65357207832813 0.00392332371788721 no 45 0.00398223792766256 111 761523 Stimulates phospholipase C.
SGTC_3198 9112019 49.47 µM 2.6299469477199 0.00420408568276626 no 46 0.0042699096919888 88 45595555
SGTC_3229 9132204 49.47 µM 2.60159727398232 0.00456462174894179 no 47 0.00463953729747605 45 17682924
SGTC_1033 k072-0102 21.3 µM 2.57781446932334 0.00488810428917351 no 48 0.00497136829761554 119 5965931
SGTC_812 4251-0442 148 µM 2.57093105199211 0.00498546607186741 no 49 0.00507127587513439 62 5723007
SGTC_1684 st024538 14.6195 µM 2.54909196757467 0.00530590062787463 no 50 0.00540019071421037 108 6732859
SGTC_3130 9127414 49.47 µM 2.53078541056319 0.0055884816156981 no 51 0.00569037259277518 83 1494646
SGTC_2628 lathosterol 100 µM 2.49240442612604 0.00622468715045651 no 52 0.00634407363742008 127 6710616
SGTC_347 4534-1311 26.2 µM 2.48963691329526 0.00627294893567024 no 53 0.00639368279474963 104 2862016
SGTC_2922 7999257 32.47 µM 2.488059779028 0.00630060003128351 no 54 0.00642210707403386 81 2988377
SGTC_3036 9090181 49.47 µM 2.47824805766323 0.00647506042321013 no 55 0.00660146591645983 66 25236586
SGTC_2465 5809242 33.21 µM 2.45042190225889 0.00699329335668466 no 56 0.00713444563497314 50 2731748
SGTC_1003 4049-0218 100 µM 2.44257891106308 0.00714582493486461 no 57 0.00729137058960194 150 295161
SGTC_3241 9133421 49.47 µM 2.4419686196044 0.00715781612506262 no 58 0.0073037081415532 36 17018221
SGTC_1682 st012968 530 nM 2.44011493617182 0.00719434675841633 no 59 0.0073412948195587 113 24207270
SGTC_1822 st052468 42 µM 2.4337788833168 0.00732045627475606 no 60 0.0074710599182608 93 2873678
SGTC_3243 9134147 49.47 µM 2.43092741458651 0.00737784346642921 no 61 0.00753011565546044 52 24282180
SGTC_2714 st079313 56.9 µM 2.42073195143949 0.00758628830910879 no 62 0.00774464701114474 98 2939799
SGTC_2936 9038235 15.59 µM 2.41874278564728 0.00762755581622839 no 63 0.00778712425232314 145 4749415
SGTC_1634 st006576 41 µM 2.41827144467833 0.00763736323842878 no 64 0.00779721940056492 136 3915356
SGTC_504 lovastatin 124 µM 2.41247465622912 0.00775889083533998 no 65 0.00792231948295419 87 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1573 oleylamine 1.06 µM 2.41220633775186 0.00776455701473866 no 66 0.00792815254898274 151 5356789 An amine of the fatty acid oleic acid.
SGTC_1836 st055642 81 µM 2.41037369385658 0.00780335508743963 no 67 0.00796809410655622 162 8571
SGTC_3239 9133757 49.47 µM 2.38575265457156 0.00834137656678996 no 68 0.00852210512314383 52 17036923
SGTC_604 1000-0114 314 µM 2.38549915773855 0.00834708133695394 no 69 0.0085279807181187 133 1572745
SGTC_961 1252-1571 372 µM 2.38383927215766 0.00838452063438423 no 70 0.00856654175364286 153 6813498
SGTC_2516 gossypol 71.55 µM 2.37440201934382 0.00860019565214268 no 71 0.00878870033072513 134 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3005 9076496 71.4286 µM 2.37137121873676 0.00867048519980088 no 72 0.00886111072642126 87 21368410
SGTC_1567 st069303 68.4 µM 2.36107453880589 0.0089130603070599 no 73 0.00911103381190735 149 5581319
SGTC_1539 benzyladenosine 56 µM 2.34299208211859 0.00935347054460216 no 74 0.00956489453163821 104 92208 A nucleotide analog.
SGTC_3008 9078912 71.4286 µM 2.34217084689187 0.00937391651619274 no 75 0.00958596826108481 121 16648731
SGTC_3193 9111931 49.47 µM 2.34186768017466 0.00938147421341167 no 76 0.00959375807712385 137 17087244
SGTC_771 0250-0039 27.3 µM 2.33585264764173 0.00953252989736016 no 77 0.00974946130494984 120 3005115
SGTC_760 0568-0725 82.9 µM 2.31799964525584 0.00999346356005291 no 78 0.0102246701689074 106 3916171
SGTC_1500 4488-1866 171 µM 2.30098805573363 0.0104506545839882 no 79 0.0106961531126336 140 2900003
SGTC_2865 9030313 51.95 µM 2.30060378487606 0.0104611891221157 no 80 0.0107070184560625 116 42562754
SGTC_3280 9140961 49.47 µM 2.295957378044 0.0105893016882582 no 81 0.0108391592505111 113 4901226
SGTC_1384 3089-0840 101 µM 2.26842601309549 0.0113768035037767 no 82 0.0116516268845183 130 1069836
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 2.26077990510701 0.0116043453167523 no 83 0.0118864447750711 192 442882
SGTC_929 2805-0021 398 µM 2.26077953312898 0.0116043564819369 no 84 0.0118864562979416 152 3098024
SGTC_2405 ticlatone 3.52 µM 2.25980106269538 0.0116337582671102 no 85 0.0119168002154434 225 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1768 st044301 37.178 µM 2.25447313396282 0.0117949932015424 no 86 0.012083209480402 160 3931349
SGTC_2285 7945142 200 µM 2.23249912597276 0.0124806340039375 no 87 0.0127909964649921 167 2970608
SGTC_757 1066-0008 322 µM 2.23225249152889 0.0124885214227502 no 88 0.0127991399470286 164 6842497
SGTC_2471 5466956 24.79 µM 2.2254086283668 0.0127091177254039 no 89 0.0130269094164891 110 724419
SGTC_904 1141-0088 396 µM 2.2227295520385 0.0127963854872808 no 90 0.0131170209665986 152 1378119
SGTC_1458 k015-0034 6.33 µM 2.21492057429032 0.0130537175163031 no 91 0.01338275832554 148 3598957
SGTC_3192 9110362 49.47 µM 2.2093924547703 0.0132385808493869 no 92 0.0135736776947845 135 16649480
SGTC_1311 1190-0148 100 µM 2.20695457284954 0.0133208209176601 no 93 0.01365861659433 202 1961333
SGTC_29 0299-0004 12.984 µM 2.20426993419221 0.0134118952927048 no 94 0.0137526830342776 110 16871 A napthoquinone isolated from Swertia calycina.
SGTC_774 k060-0086 136 µM 2.19669685262161 0.0136717095951318 no 95 0.0140210519019387 196 5911235
SGTC_248 streptozotocin 5.23457 mM 2.19418970980567 0.0137586751577712 no 96 0.0141108870165484 179 5300 DNA alkylating agent.
SGTC_2472 5377652 49.4 µM 2.1838965210325 0.0141207354834186 no 97 0.0144849263632747 235 1610903
SGTC_2165 5727197 32.143 µM 2.17945265378872 0.014279567089249 no 98 0.0146490291262161 212 1361712
SGTC_1075 aripiprazole 15.2 µM 2.17011635674546 0.0146182813845551 no 99 0.014999016185713 218 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2416 tofa 880 nM 2.16518204952668 0.0148000708275282 no 100 0.0151868732253157 214 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2593 nobiletin 86.24 µM 2.14666103396962 0.0154998697095629 no 101 0.0159101385272115 180 72344 An anti-infammatory.
SGTC_1763 st044482 94.5 µM 2.14571228182253 0.0155364695989191 no 102 0.0159479703495231 188 88505
SGTC_3256 9138902 49.47 µM 2.14403869573094 0.0156012121495375 no 103 0.0160148931965649 84 17228773
SGTC_2833 9001315 45.46 µM 2.14189243471328 0.0156845788057967 no 104 0.0161010693929113 236 2989378
SGTC_2470 5664817 21.68 µM 2.13729577548831 0.0158644121947384 no 105 0.0162869711251093 140 2859561
SGTC_1702 st027038 51 µM 2.13705412614966 0.0158739148714349 no 106 0.0162967947555407 183 5521182
SGTC_1018 4259-0013 28.1 µM 2.12385315600886 0.0164005019173082 no 107 0.0168412122497498 170 6801262
SGTC_691 1548-0686 185 µM 2.12117843117236 0.0165089999610295 no 108 0.0169533948220328 231 46495133
SGTC_2202 7226349 200 µM 2.1209975479924 0.0165163594693587 no 109 0.016961004385066 129 844334
SGTC_1268 0828-0275 2.46 µM 2.11273345676825 0.0168556048088863 no 110 0.0173117939959703 199 745337
SGTC_2797 7859098 81.82 µM 2.10396043298215 0.0172222455019911 no 111 0.0176909493053322 199 972681
SGTC_385 1494-0393 12.4 µM 2.0944225777486 0.017628559369357 no 112 0.0181111766291434 203 3090647
SGTC_2301 7769476 200 µM 2.09332450723586 0.0176758582943808 no 113 0.0181600981926166 164 977820
SGTC_2560 caryophyllene 100 µM 2.09020310124567 0.0178109034262797 no 114 0.0182997795413513 207 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_48 0382-0018 55 µM 2.07743196118848 0.0183726412345488 no 115 0.0188808544330911 167 762596
SGTC_966 1300-0360 30.2 µM 2.06368090968612 0.0189942836339978 no 116 0.0195239902736636 212 70588
SGTC_2580 diallyl disulphide 81.36 µM 2.06004554708874 0.0191615859766377 no 117 0.0196970933800325 209 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1480 1070-0044 41.2 µM 2.05737961691813 0.0192850689791621 no 118 0.0198248621295963 208 3124987
SGTC_1232 0279-0259 161 µM 2.04104619135936 0.020056471426035 no 119 0.0206231180116951 210 1560000
SGTC_689 0833-0039 98 µM 2.03068012858784 0.0205594975830085 no 120 0.0211437267085139 202 5374726
SGTC_2512 diallyl trisulfide 49.23 µM 1.99924634176043 0.0221506637276182 no 121 0.0227908533634211 147 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2347 9049783 174.81 µM 1.99678990448036 0.0222792712142501 no 122 0.0229240053627757 267 6467988 YPL169C MEX67
SGTC_121 0557-0495 61.343 µM 1.99561228069838 0.0223411491017962 no 123 0.0229880708745513 351 3104427
SGTC_878 0828-0289 13.7 µM 1.98411461573857 0.0229529437184596 no 124 0.0236215320701306 296 745350 YLR208W SEC13
SGTC_1289 0976-0073 69.1 µM 1.97595473477429 0.0233956445855186 no 125 0.0240799520597333 212 3391136
SGTC_1689 st020265 53.493 µM 1.97531588807719 0.0234306053982762 no 126 0.0241161556607414 208 5758320 YPR016C TIF6
SGTC_1852 st056254 31.4 µM 1.9626420674312 0.0241333164203059 no 127 0.0248438895115209 204 442583
SGTC_1729 st035615 45.989 µM 1.94910317742595 0.0249034647430769 no 128 0.0256415521525983 240 17385451
SGTC_3184 9108758 49.47 µM 1.94769159065472 0.0249849351530717 no 129 0.0257259384669455 179 902885
SGTC_1688 st021091 57.6 µM 1.93761977793983 0.0255727433992562 no 130 0.0263348138482154 189 3656366
SGTC_1992 st073643 23.3 µM 1.93449551797844 0.0257574168707889 no 131 0.0265261163010362 202 3161292
SGTC_2868 9035608 32.47 µM 1.93291827027738 0.0258510703779147 no 132 0.0266231333979893 249 6462614
SGTC_2830 7992007 71.43 µM 1.93230530571419 0.0258875436736628 no 133 0.0266609169725779 223 1952075
SGTC_3172 9105863 49.47 µM 1.91654270128273 0.0268403601231867 no 134 0.0276480266804966 118 2348785
SGTC_3022 9087993 49.47 µM 1.91451397036222 0.026965093157405 no 135 0.0277772579047714 192 17173644
SGTC_1053 3366-3204 134 µM 1.91441151379901 0.0269714053366678 no 136 0.0277837977703251 265 3632071 YPR165W RHO1
SGTC_2361 9034121 116 µM 1.91214801765492 0.0271111704928975 no 137 0.0279286056892501 213 6496917
SGTC_3228 9131799 49.47 µM 1.90711213992096 0.0274242921261699 no 138 0.028253033763646 209 17015818
SGTC_1323 1348-1351 11.2 µM 1.90254812203165 0.0277106738306939 no 139 0.0285497669773397 213 6989654
SGTC_1063 disulfiram 1.84 µM 1.90187764594611 0.0277529538837625 no 140 0.0285935761239943 247 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_302 1094-0063 18.9 µM 1.89650085626392 0.0280939605857939 no 141 0.0289469234370735 186 5440289
SGTC_3326 9140064 16.379 µM 1.89331088598737 0.0282979187684102 no 142 0.0291582691648963 229 1868434
SGTC_2773 thioridazine 9.09 µM 1.88386644617644 0.0289090083367535 no 143 0.0297915214509906 228 5452 An antipsychotic.
SGTC_132 0417-1715 25.805 µM 1.87635093558186 0.0294030910241561 no 144 0.0303035535573644 251 6769098
SGTC_1646 st011709 75.6 µM 1.86954560296921 0.0298565148705201 no 145 0.0307734726272756 205 5757843
SGTC_2808 7946468 45.46 µM 1.86923435840332 0.0298773903253917 no 146 0.0307951080305962 306 2970879
SGTC_3221 9128209 49.47 µM 1.86610462725456 0.0300879779487402 no 147 0.0310133643610833 225 16460723
SGTC_2133 5320837 200 µM 1.85940560058816 0.0305428675092381 no 148 0.0314848342789086 255 2841355
SGTC_3159 9100096 49.47 µM 1.84991896077184 0.0311967787560274 no 149 0.0321626153152031 264 25236875
SGTC_2940 9060638 45.86 µM 1.84779085652011 0.0313450476416069 no 150 0.0323163020784686 290 4027022
SGTC_2464 5717415 7.67 µM 1.84068642534461 0.0318442516382394 no 151 0.0328337621738811 277 5285744
SGTC_3206 9114350 49.47 µM 1.84021750198282 0.0318774310152901 no 152 0.0328681557264257 264 17087243
SGTC_1297 1068-0111 14.1 µM 1.83936177736601 0.0319380526954957 no 153 0.0329309960646375 235 767057
SGTC_932 2857-0803 154 µM 1.83484514456249 0.0322596017919857 no 154 0.0332643187222334 286 674898
SGTC_2412 st077135 33.4 µM 1.82555115460259 0.0329296697123702 no 155 0.0339589495485342 290 13258915
SGTC_3317 9138495 8.753 µM 1.82493637522354 0.0329743949320867 no 156 0.0340053156014388 294 17020139
SGTC_1850 st056238 17 µM 1.8238020536569 0.0330570482580057 no 157 0.0340910016560358 291 5393177
SGTC_1339 1486-1321 22.7 µM 1.82212451355103 0.0331795965204268 no 158 0.0342180474938741 277 3469382
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.81991747933225 0.0333413954066518 no 159 0.0343857863115406 314 6708561
SGTC_1853 st056710 91.2 µM 1.81416736341572 0.0337659931052127 no 160 0.0348259815490531 265 269167
SGTC_2815 7968870 71.43 µM 1.8107246180148 0.0340223332842112 no 161 0.0350917450646742 327 2977326 YHR190W ERG9
SGTC_333 3486-0131 40.1 µM 1.80678824438428 0.0343173868016061 no 162 0.0353976511670296 273 6744690
SGTC_2333 9017922 200 µM 1.80480463810922 0.0344668643215023 no 163 0.035552629181066 278 3163164
SGTC_1326 1431-2094 10.8 µM 1.7968359885608 0.0350727536988951 no 164 0.0361808305814497 323 616278
SGTC_95 0471-0001 561.058 µM 1.78469185789931 0.0360129079377887 no 165 0.0371556561707059 301 4015405
SGTC_2058 5236698 133 µM 1.78309513993933 0.0361380413904055 no 166 0.0372854087261964 297 766665
SGTC_289 k017-0060 526 µM 1.78191311892534 0.0362309045442001 no 167 0.0373817004221394 244 5512909
SGTC_2163 5671233 125 µM 1.7810163562554 0.0363014871930022 no 168 0.0374548893740243 319 701023
SGTC_2618 avocadyne 43.43 µM 1.7810098319103 0.03630200112513 no 169 0.0374554222845308 265 3015189
SGTC_493 zm226600 134 µM 1.78011893605121 0.0363722342368148 no 170 0.0375282491061025 297 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1436 4092-1007 8.32 µM 1.77979848636761 0.0363975238284392 no 171 0.0375544727184583 277 2881121
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.77632084449116 0.0366729026993943 no 172 0.0378400247302658 289 66535 A nucleotide analog.
SGTC_2942 9052777 62.25 µM 1.77453221259399 0.0368151987413741 no 173 0.037987579345187 338 6469503
SGTC_1888 azatryptophan 97.5 µM 1.77045581389766 0.0371411873265674 no 174 0.0383256194836662 246 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_3329 9141233 27.5565 µM 1.76757112588104 0.0373732974059408 no 175 0.0385663143243836 269 4909101 YNL103W MET4
SGTC_2253 7938677 135.83 µM 1.76683175498775 0.0374329796397061 no 176 0.0386282044552367 274 2301972
SGTC_2556 citropten 84.59 µM 1.76567540486894 0.0375264766080438 no 177 0.0387251606818774 339 2775 A potential DNA crosslinker.
SGTC_2607 solasodine 47.35 µM 1.76115373296749 0.0378939098653351 no 178 0.0391061932633623 351 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_838 0109-0203 71.4 µM 1.75771388065947 0.0381753956824173 no 179 0.0393981024226184 282 759422
SGTC_3082 9117008 49.47 µM 1.74923535327902 0.0388764862901664 no 180 0.0401251726854052 291 41448529
SGTC_3171 9103192 49.47 µM 1.7480407962537 0.0389761018782676 no 181 0.0402284817101175 229 13018434
SGTC_2147 5545932 89.7195 µM 1.7447140197773 0.0392546216886534 no 182 0.0405173308300656 277 797404
SGTC_3035 9091303 49.47 µM 1.74235162490136 0.0394533846619182 no 183 0.0407234675734241 243 25237002
SGTC_212 3807-4682 38.772 µM 1.73950715852298 0.039693792858883 no 184 0.0409727970802484 437 3125501 YBL034C STU1
SGTC_1672 st016598 6.51 µM 1.72169438058956 0.0412265036575522 no 185 0.0425624479135193 354 4665860 YNL267W PIK1
SGTC_60 0986-0278 202 µM 1.71667988285681 0.0416665289690372 no 186 0.0430188388965913 233 3110598
SGTC_3046 9092212 49.47 µM 1.71329709283566 0.04196551406051 no 187 0.0433289484811715 278 25236637
SGTC_2521 angolensin 13.4 µM 1.71210848914584 0.0420709792529676 no 188 0.0434383386129433 281 821428 A flavenoid.
SGTC_235 0330-0087 5 mM 1.71004798598232 0.0422543165881877 no 189 0.0436284999637185 350 46494818 YHR062C RPP1
SGTC_1084 voriconazole 435 nM 1.70913814702772 0.0423354767836338 no 190 0.043712681441439 303 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2835 9006588 71.43 µM 1.70788689076084 0.0424472982891299 no 191 0.0438286660407213 352 2345538
SGTC_62 0180-0423 3.232 µM 1.70704038993489 0.0425230832405997 no 192 0.0439072727188832 308 30102 YGL099W LSG1
SGTC_1964 st076914 61 µM 1.70080523349819 0.0430846770484783 no 193 0.0444897831097847 287 24208661
SGTC_3301 9125354 19.7965 µM 1.69914479000027 0.0432352373503693 no 194 0.0446459529566145 275 41905162
SGTC_3279 9140807 49.47 µM 1.6911132660145 0.0439695021841224 no 195 0.0454075859980536 293 45595718
SGTC_1224 0823-0416 294 µM 1.68957700053965 0.0441110912518514 no 196 0.0455544545597379 316 3598164
SGTC_118 0083-0097 135.343 µM 1.68815902828727 0.0442421039026557 no 197 0.0456903529091778 587 5207356
SGTC_3196 9111891 49.47 µM 1.68647735145561 0.0443978877391017 no 198 0.045851946912332 286 18891510
SGTC_2558 carylophyllene oxide 100 µM 1.6863715248521 0.0444077058581663 no 199 0.0458621312367216 343 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.68623590399349 0.0444202907125901 no 200 0.0458751854971199 369 6708784 An antioxidant flavonoid
SGTC_1651 st011928 86.1 µM 1.68563116273727 0.0444764422876604 no 201 0.0459334315452155 301 720198
SGTC_2979 9012552 45.46 µM 1.68515983314295 0.0445202459361737 no 202 0.045978869152503 249 17100905
SGTC_1562 morin hydrate 59.1 µM 1.68259444218922 0.044759273735181 no 203 0.0462268141723265 330 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1610 st001799 48.1 µM 1.67323884641877 0.045639741095891 no 204 0.0471401429075185 269 621897
SGTC_1977 st070720 65.3 µM 1.67322138517712 0.0456413973203465 no 205 0.047141860967297 291 682188
SGTC_3135 9127742 49.47 µM 1.67032381249098 0.0459169063189252 no 206 0.0474276571601194 296 3643468
SGTC_364 0083-0097 67.7 µM 1.66570851895559 0.0463584986135592 no 207 0.047885742195489 335 5207356
SGTC_2185 6113692 200 µM 1.66387223424772 0.0465351401456137 no 208 0.0480689823927408 307 874150
SGTC_3223 9129970 49.47 µM 1.66033943052125 0.0468764975397516 no 209 0.0484230938008634 365 17248386
SGTC_254 nsc-64875 3.808 µM 1.65956647115929 0.0469514519206274 no 210 0.0485008490519099 326 56993
SGTC_3286 9117135 37.221 µM 1.65561375009299 0.047336253574611 no 211 0.0489000319149801 349 3438150
SGTC_2349 9023730 187.07 µM 1.65457003495668 0.0474382810213389 no 212 0.0490058730064982 364 4126287
SGTC_3268 9137683 49.47 µM 1.65372577202739 0.0475209400358031 no 213 0.0490916218714048 256 1953228
SGTC_3267 9137951 49.47 µM 1.65256272149081 0.0476349994123601 no 214 0.0492099451135332 250 16643986
SGTC_422 cantharidin 155 µM 1.64996170661547 0.0478908722405502 no 215 0.0494753842274463 409 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_544 k015-0020 52.4 µM 1.64280051362028 0.0486010370010457 no 216 0.0502121069578227 325 3008304
SGTC_2651 TUB2.036 5 µM 1.64139914205213 0.0487409890249505 no 217 0.0503572939351983 572 15992207 YFL037W TUB2
SGTC_1111 tnp00062 510.699 nM 1.63441624001446 0.0494431647565981 no 218 0.0510857402699409 320 676306
SGTC_90 0870-0863 4.608 µM 1.63097597786834 0.0497920621233675 no 219 0.0514476942036845 395 1738164
SGTC_3088 9117578 49.47 µM 1.62976943417009 0.0499148890380555 no 220 0.0515751180739786 322 678341
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.62558049806797 0.0503432022347576 no 221 0.0520194633203113 286 15053
SGTC_2104 5389443 200 µM 1.62540846961462 0.0503608543343435 no 222 0.0520377762106123 395 2244536
SGTC_2377 9073351 62.6 µM 1.62351131207657 0.0505558518380774 no 223 0.0522400735832155 349 7337946 YHR072W ERG7
SGTC_2153 5569715 200 µM 1.62205677208197 0.0507057622892072 no 224 0.0523955964169978 325 2054701
SGTC_3143 9086658 49.47 µM 1.61612805556795 0.0513204640273547 no 225 0.0530333147798754 435 25236626
SGTC_2150 5556613 200 µM 1.61565748220913 0.0513695068958742 no 226 0.053084194205237 383 743190
SGTC_1842 st055362 61.2 µM 1.61427865720586 0.051513421860845 no 227 0.0532334986731228 384 676032
SGTC_2261 9010538 184.68 µM 1.60899568149025 0.0520678026613005 no 228 0.0538086429594314 299 6457250
SGTC_1486 3970-0793 4.53 µM 1.60606274543109 0.0523776167240767 no 229 0.0541300621679851 336 2844330
SGTC_158 k038-0087 26.446 µM 1.6049045442569 0.0525003630603217 no 230 0.0542574066736145 506 X158
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.59979901005719 0.053044172318676 no 231 0.0548215892567019 374 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1031 k035-0009 16 µM 1.59888790860446 0.0531416851242015 no 232 0.0549227555898826 400 5180959
SGTC_1613 st002381 52.1 µM 1.59371787136048 0.053697714897457 no 233 0.0554996198017494 377 551167
SGTC_1252 0493-0875 34.8 µM 1.59213211566865 0.0538691809045031 no 234 0.0556775111498994 372 3960963
SGTC_1713 st033146 12.748 µM 1.58093688027957 0.0550920737860765 no 235 0.0569462353247094 383 674619
SGTC_2731 amoxapine 43.43 µM 1.57828700189887 0.0553847149654044 no 236 0.0572498453255686 198 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_389 tpck 16.7 µM 1.57683070728529 0.0555460637481815 no 237 0.0574172419814889 357 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1347 1493-0251 600 nM 1.57381249502474 0.0558816449973382 no 238 0.0577654022529841 392 3986378
SGTC_2155 5570423 76 µM 1.57337850540635 0.0559300295762164 no 239 0.0578156005294259 369 797402
SGTC_983 1491-0821 12.2 µM 1.56848004363579 0.0564784430635063 no 240 0.0583845718626989 342 46495113
SGTC_1057 3448-5381 134 µM 1.56717569627689 0.0566251850804329 no 241 0.0585368148038208 407 5497911
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.5659923753549 0.0567585710666011 no 242 0.0586752010811879 396 5282309
SGTC_1197 1601-0112 267 µM 1.56395868912633 0.0569883897419569 no 243 0.0589136351449121 412 7350313
SGTC_1594 piperine 70.1 µM 1.56107846038909 0.0573151256323315 no 244 0.0592526197892587 408 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3163 9099914 49.47 µM 1.55923293039971 0.0575252579836752 no 245 0.0594706297047638 277 16268368
SGTC_209 4077-0173 175.592 µM 1.55764152354248 0.0577069419829053 no 246 0.0596591248104875 278 15993494
SGTC_2534 helenine 20.12 µM 1.55608915149198 0.057884603995448 no 247 0.0598434471675765 339 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1381 2324-0066 62.1 µM 1.55263647324129 0.0582812890086041 no 248 0.0602550034593624 410 10885928
SGTC_1922 5578187 25 µM 1.5516948015961 0.058389849319717 no 249 0.060367633568348 389 1350412
SGTC_216 k038-0035 28.382 µM 1.55016768000418 0.0585662405746418 no 250 0.0605506375072272 353 4444231 YPR107C YTH1
SGTC_2679 rapamycin 1 nM 1.54908214311382 0.0586918804698956 no 251 0.0606809874662143 531 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2925 9010536 32.5 µM 1.54651436953657 0.0589899163479915 no 252 0.0609901962174531 476 2994177
SGTC_3141 9094609 49.47 µM 1.54552923971555 0.059104572858326 no 253 0.0611091509763275 397 25236309 YDL196W YDL196W
SGTC_213 1246-0773 967 nM 1.54366365243997 0.0593221822318197 no 254 0.061334918034738 421 6251622
SGTC_3275 9138069 49.47 µM 1.54323927306399 0.0593717710899857 no 255 0.061386365854117 363 17617007
SGTC_1127 asiatic acid 681.4 nM 1.54309634667324 0.0593884793955777 no 256 0.0614037005107465 409 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_782 0083-0095 30.5 µM 1.54235593447088 0.05947509368998 no 257 0.0614935617403635 447 3591729 An indicator and reagent.
SGTC_337 1315-0038 354 µM 1.53818647491388 0.0599646920870841 no 258 0.0620015134954016 386 1626437
SGTC_764 1951-2361 146 µM 1.53571929059791 0.0602558840362979 no 259 0.062303620887372 416 5438930
SGTC_2872 9044037 25.97 µM 1.53480237679234 0.0603643854117287 no 260 0.06241618940393 315 6465195
SGTC_3182 9108849 49.47 µM 1.53168008402498 0.0607350035356986 no 261 0.0628006996946319 454 17133045
SGTC_618 k072-0232 33.2 µM 1.52568132345204 0.0614520518853678 no 262 0.0635446239928587 372 5872756 YGL099W LSG1
SGTC_2326 6164455 177.58 µM 1.52387133770707 0.0616696980721373 no 263 0.0637704273381816 391 2888790
SGTC_1216 1165-0504 9.65 µM 1.52231110997284 0.0618577940995753 no 264 0.0639655727994427 417 6304004
SGTC_1939 st074455 53.6 µM 1.52039164431132 0.0620898126597523 no 265 0.064206286626233 426 1644229
SGTC_1307 1187-1599 12.2 µM 1.52000009453708 0.0621372251541977 no 266 0.0642554759389683 394 1538471
SGTC_2019 4016004 108 µM 1.51905677388544 0.0622515671988163 no 267 0.0643741029776284 362 45595336
SGTC_1748 st037455 53.6035 µM 1.51363592276798 0.0629118250644356 no 268 0.0650591024366202 430 580690
SGTC_1265 0819-1001 68.8 µM 1.50529250895412 0.0639386948036516 no 269 0.0661244451333578 407 3106768
SGTC_2789 5281112 71.43 µM 1.50443801859259 0.0640445932013508 no 270 0.0662343106450775 434 765948
SGTC_3248 9135562 49.47 µM 1.50242727217492 0.0642943263063692 no 271 0.0664933987309316 428 17650701
SGTC_3013 9080133 71.4286 µM 1.4949245650918 0.0652328414021374 no 272 0.0674670652026913 473 17050193
SGTC_2749 bexarotene 57.39 µM 1.49403466292056 0.0653448609763291 no 273 0.0675832797915261 441 82146 An retinoic acid receptor inhibitor.
SGTC_2084 5306078 60.6385 µM 1.49091213277822 0.0657391011459621 no 274 0.0679922827702854 413 679340
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.47958450028206 0.0671847811270954 no 275 0.0694920827132276 341 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_271 rotenone 740 µM 1.47710624343078 0.0675043198773317 no 276 0.0698235801112194 469 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2875 9039966 71.43 µM 1.47161664570137 0.0682163125303798 no 277 0.0705622139857152 366 6463691
SGTC_2907 7721985 69.9 µM 1.47071919345685 0.0683332599735455 no 278 0.0706835366801103 435 3267881
SGTC_231 b-estradiol 524 µM 1.46572092835465 0.0689874185676266 no 279 0.0713621651109604 362 450 A steroid.
SGTC_2363 9053361 176 µM 1.4623195981545 0.0694353275999402 no 280 0.0718268252347523 457 6469797 YMR079W SEC14
SGTC_1514 1189-1591 158 µM 1.46103589596854 0.0696049547213396 no 281 0.0720027953430946 504 767698 YMR146C TIF34
SGTC_3053 9095903 49.47 µM 1.45804807269585 0.0700009980538273 no 282 0.0724136464522417 404 17174018
SGTC_1802 st050112 57.9 µM 1.45797948056598 0.0700101104255919 no 283 0.0724230994998126 450 4662563
SGTC_3003 9075612 71.4286 µM 1.45383988290648 0.0705617417095833 no 284 0.072995351608636 446 6501993
SGTC_1131 3454-3128 32.3 µM 1.4456767752116 0.0716593169306806 no 285 0.0741339407048847 513 710982
SGTC_2071 5230951 39.92 µM 1.44255956515738 0.0720818819276811 no 286 0.0745722903765076 473 1799272
SGTC_1686 st019653 115.5 µM 1.44005523898734 0.0724227468319897 no 287 0.0749258857398782 429 97252
SGTC_98 0074-0023 107.663 µM 1.43869232707693 0.0726087715558465 no 288 0.0751188571234999 486 3563821
SGTC_3138 9097216 49.47 µM 1.43452764052939 0.0731794802637271 no 289 0.0757108735641829 434 25237486
SGTC_2206 7254556 146.969 µM 1.4339832610545 0.0732543323627484 no 290 0.0757885198486411 377 4398905
SGTC_1864 st057645 30.4 µM 1.42908894394356 0.073929933076221 no 291 0.0764893354106783 403 688666
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.42818959706435 0.0740545931146165 no 292 0.076618647040909 450 7104
SGTC_582 0987-0078 156 µM 1.42698460361343 0.0742218709987655 no 293 0.0767921662790772 620 1625765
SGTC_2956 9076196 2.52 µM 1.42007967909886 0.0751859862406655 no 294 0.0777922427639732 473 16423868
SGTC_475 α-linolenic acid 10 µM 1.41926579427259 0.07530025290861 no 295 0.0779107702662182 487 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3339 9145883 14.936 µM 1.41890866521194 0.0753504343861819 no 296 0.0779628228492734 431 2030670
SGTC_688 0527-0193 473 µM 1.41579217291305 0.0757894261932917 no 297 0.0784181809550433 441 4007154
SGTC_334 1502-1024 68.5 µM 1.41573271082313 0.0757978209726974 no 298 0.078426888664575 484 3296216
SGTC_1714 st033236 13.627 µM 1.41363943712403 0.0760937981058977 no 299 0.0787338978872315 501 2916566
SGTC_3051 9093778 49.47 µM 1.41324884606064 0.0761491227550128 no 300 0.0787912844651289 381 17217378
SGTC_1994 st072947 40.9 µM 1.41287697872695 0.0762018237575997 no 301 0.0788459495517867 471 5286565 YDL195W SEC31
SGTC_96 0929-0093 37.281 µM 1.41279569487317 0.0762133469937253 no 302 0.0788579022328044 448 6991579
SGTC_1318 1280-3875 124 µM 1.41181803908753 0.0763520486586783 no 303 0.0790017727650893 503 373245
SGTC_980 1473-0395 201 µM 1.41068332746873 0.076513272836425 no 304 0.0791690046015101 412 768876
SGTC_2897 9048598 12.99 µM 1.40994470177266 0.0766183586761163 no 305 0.0792780059192393 441 6467404
SGTC_2484 5809818 12.04 µM 1.4088932027091 0.0767681469868697 no 306 0.0794333748870011 463 2870548
SGTC_1418 3966-3099 2.4 µM 1.40620394785306 0.0771522500086038 no 307 0.0798317861100471 497 740335
SGTC_836 0330-0104 1.35 µM 1.40401558429548 0.0774658875543583 no 308 0.0801571044607006 465 46494820
SGTC_1002 4049-0206 172 µM 1.40372789746439 0.077507190909188 no 309 0.0801999459082283 531 4662749
SGTC_1200 1643-0193 18.4 µM 1.40244277828047 0.0776919003973014 no 310 0.0803915332972244 506 5403974
SGTC_2923 7992654 58.14 µM 1.40145502888858 0.0778340960617364 no 311 0.080539023264582 471 2985126
SGTC_3210 9128157 49.47 µM 1.39723736716202 0.0784434905526452 no 312 0.0811711016703765 477 17590849
SGTC_789 1309-1135 70.6 µM 1.39608936211526 0.0786099862507766 no 313 0.0813437934206568 509 3092424
SGTC_1887 st057648 70.8 µM 1.39407271002428 0.0789031105337866 no 314 0.0816478245554548 482 688672
SGTC_1441 4106-0040 13 µM 1.38783370125589 0.0798152062355075 no 315 0.0825938449903939 477 2904180
SGTC_779 1360-0071 233 µM 1.37964625946638 0.0810242184603771 no 316 0.0838477934572513 535 7566
SGTC_1960 st011366 51.8 µM 1.37932438423984 0.081072029540056 no 317 0.0838973807977518 447 3972846
SGTC_677 0929-0063 136 µM 1.37738698815481 0.0813602586192909 no 318 0.0841963168071059 409 1539583
SGTC_2826 7992541 19.48 µM 1.37434180687463 0.0818148557126405 no 319 0.0846677965338337 469 2985066
SGTC_1163 k060-0048 49.9 µM 1.37399208586555 0.0818671858083617 no 320 0.0847220696926957 544 6809982
SGTC_2173 5763948 167 µM 1.37320228586026 0.0819854594183003 no 321 0.0848447346397577 524 2867177
SGTC_3079 9117512 49.47 µM 1.37248975753294 0.0820922719200744 no 322 0.0849555126238294 483 7185044
SGTC_1913 st060213 96.1 µM 1.3681109071204 0.0827509922027299 no 323 0.0856386815602529 538 688959
SGTC_2762 leflunomide 42.06 µM 1.36661221373502 0.0829773552267812 no 324 0.0858734434254517 542 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1 0258-0098 57.368 µM 1.36558595293331 0.0831326303775796 no 325 0.0860344790060692 426 6790032 YDR047W HEM12
SGTC_2984 9022109 38.96 µM 1.36360034752722 0.0834336763311236 no 326 0.0863466913396518 434 6459207
SGTC_1072 oxiconazole 14.9 nM 1.36207458480366 0.0836655597602824 no 327 0.0865871740703094 538 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2232 chlorophetanol 41.5365 µM 1.36081732008857 0.0838570008115291 no 328 0.086785713508502 653 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2975 9084847 53.72 µM 1.3587569677224 0.0841714373805605 no 329 0.0871118067565092 506 27211724
SGTC_830 4076-0286 57.8 µM 1.35827267255766 0.0842454754218194 no 330 0.0871885891054419 667 6866659
SGTC_3304 9125678 46.087 µM 1.35643335936246 0.0845271111776685 no 331 0.0874806626098499 530 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1883 5-benzylidenerhodanine 20 µM 1.35454017480032 0.0848177327467262 no 332 0.0877820525919069 592 1273210
SGTC_1440 4100-1550 40 µM 1.35026406510231 0.085476911881479 no 333 0.0884656473461778 454 742806
SGTC_2661 dactinomycin 12.96 µM 1.34771421293767 0.0858718034702722 no 334 0.0888751594670673 544 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2649 anisomycin 9.56 µM 1.34764050542308 0.0858832387075436 no 335 0.0888870180166442 450 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1295 1013-0063 9.78 µM 1.34612026171412 0.0861193487752078 no 336 0.0891318676050637 521 6826038
SGTC_2597 laccaic acid a 100 µM 1.33980493559641 0.0871053865234614 no 337 0.0901543853136213 535 5491415 A textile dye.
SGTC_1557 sumaresinolic acid 42.3 µM 1.33879972728727 0.0872631085446948 no 338 0.0903179398032154 490 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1151 3909-8316 15.3 µM 1.33784769413386 0.0874126836388694 no 339 0.0904730454037222 517 800431
SGTC_2656 pseudo-anisatin 100 µM 1.33498007454292 0.0878643751451316 no 340 0.0909414339856926 461 6708809 A neurotoxin.
SGTC_3121 9125696 49.47 µM 1.33482675221356 0.0878885745614247 no 341 0.0909665277740371 463 1235365
SGTC_2801 7907800 81.82 µM 1.33346813742953 0.0881032268467282 no 342 0.0911891124828745 548 6620925
SGTC_370 0180-0345 38.7 µM 1.33265474873058 0.0882319238667657 no 343 0.0913225647924655 469 3989527
SGTC_1700 st030840 7.9285 µM 1.33207016528467 0.0883245050776871 no 344 0.0914185665169547 563 5499307
SGTC_2539 epi(13)torulosol 80 µM 1.3312062912939 0.0884614503937703 no 345 0.0915605709420084 510 6708597
SGTC_2733 amorolfine 100 µM 1.32633266127742 0.0892370058730661 no 346 0.0923647664314082 396 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_759 3486-0358 89.3 µM 1.32541870047782 0.0893830088541193 no 347 0.0925161589635295 577 875103
SGTC_395 anisomycin 6.25 µM 1.32533104663317 0.0893970206721013 no 348 0.0925306879782218 450 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_174 3553-0389 74.3 µM 1.31857083633932 0.0904825958869048 no 349 0.0936563144478423 492 738071
SGTC_1406 3909-7906 11.9 µM 1.31523999300677 0.0910210584641454 no 350 0.094214629087906 546 X1406
SGTC_2855 9016525 58.44 µM 1.31168084825312 0.0915990510583622 no 351 0.0948139206744237 529 43811474
SGTC_625 k213-0058 121 µM 1.30429052713858 0.0928078921231127 no 352 0.0960672719589615 739 3655420
SGTC_3025 9087895 49.47 µM 1.30081698450872 0.0933801207879032 no 353 0.0966605534383779 581 17173641
SGTC_137 0438-0332 85.389 µM 1.30060737252935 0.0934147353010346 no 354 0.0966964410977623 686 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1016 4226-1401 38 µM 1.29925704536631 0.0936379503368955 no 355 0.0969278651682187 559 2901613
SGTC_931 2812-0076 566 µM 1.29912377321598 0.0936600021461967 no 356 0.0969507278711114 575 3450959
SGTC_1067 clotrimazole 1.36 µM 1.29906462645659 0.0936697900633807 no 357 0.0969608757062865 580 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1202 1988-0068 29.6 µM 1.29890741985375 0.0936958091111291 no 358 0.0969878515019007 565 2850480
SGTC_1482 3346-2049 8.48 µM 1.29794105221055 0.0938558685124488 no 359 0.0971537959512631 525 3826804
SGTC_1126 isoteolin 1.0172 µM 1.29636116003361 0.0941179804776827 no 360 0.0974255433416544 543 133323
SGTC_335 4077-0256 27.6 µM 1.29433685008622 0.0944546123309973 no 361 0.0977745465847994 621 3121989
SGTC_1168 k815-0004 80.5 µM 1.29405452260029 0.0945016323270257 no 362 0.0978232942803977 557 642433
SGTC_1963 st076565 50.3 µM 1.29323916510885 0.0946375222441939 no 363 0.0979641769007652 543 4914280
SGTC_330 1488-0319 80.1 µM 1.29189218310606 0.0948623297192127 no 364 0.0981972425853507 556 6846614
SGTC_2373 9071805 200 µM 1.28915385931802 0.0953205607660778 no 365 0.0986723011529087 552 10149009
SGTC_152 4469-0003 551.229 µM 1.28766373539505 0.0955706017313026 no 366 0.0989315212453386 529 697280
SGTC_1905 st060207 84.5 µM 1.2861880157904 0.0958187010400231 no 367 0.0991887262470795 560 1948547
SGTC_2961 9083290 32.55 µM 1.28400093987749 0.0961872650866599 no 368 0.0995708132806426 506 17741490
SGTC_2680 butyl paraben 22.24 µM 1.28245213984926 0.0964488970666536 no 369 0.0998420419029228 500 7184 An antifungal and steroid mimetic.
SGTC_3161 9100388 49.47 µM 1.28161036776041 0.0965913130685317 no 370 0.0999896806980432 559 25236368
SGTC_2087 5276107 200 µM 1.28020285253754 0.0968297898552054 no 371 0.100236901487853 542 144405
SGTC_2553 4-methylesculetin 85.09 µM 1.27894840940205 0.0970426955941655 no 372 0.100457611934711 570 5319502
SGTC_896 0964-0007 44.5 µM 1.27637795191206 0.0974800300609035 no 373 0.100910973159307 570 6756758
SGTC_894 0960-0238 55.9 µM 1.2750642544898 0.0977040983172717 no 374 0.101143250071192 572 6741907 YDL195W SEC31
SGTC_1473 k844-0725 134 µM 1.27417545920225 0.097855907980628 no 375 0.101300620199179 647 54682906
SGTC_2306 7482397 179.52 µM 1.27253224048911 0.0981370312517233 no 376 0.101592038224816 572 891448
SGTC_226 1,3-diallylurea 8.28947 mM 1.27226103167193 0.0981834867184886 no 377 0.101640194619462 509 74537 YKL182W FAS1
SGTC_2080 5212524 12.4 µM 1.26662658754304 0.0991522596478913 no 378 0.102644420502684 541 260183
SGTC_1308 1187-1617 41.4 µM 1.26589283650275 0.0992789317289824 no 379 0.102775725709987 612 2882570
SGTC_2228 7354201 200 µM 1.26535831168387 0.0993712845942784 no 380 0.102871456079631 544 753451
SGTC_2317 5986382 200 µM 1.26310293127156 0.09976165096044 no 381 0.103276095356743 586 877883
SGTC_1227 3909-8010 46.6 µM 1.25940918010424 0.100403391623565 no 382 0.103941287662749 557 15982272
SGTC_2561 acetosyringone 100 µM 1.25928615698949 0.100424816986635 no 383 0.103963495726492 652 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1102 cgs 12066b 26.1 µM 1.25802438858663 0.100644755661763 no 384 0.104191468103466 537 6438352 A 5-HT1B full agonist.
SGTC_311 1315-0136 58 µM 1.25612097627436 0.100977203653021 no 385 0.104536055999264 583 6759207
SGTC_3092 9117248 49.47 µM 1.25234508662625 0.101639064330467 no 386 0.105222073309476 603 17141857
SGTC_200 k038-0079 37.545 µM 1.24780229309837 0.102439531966774 no 387 0.106051734366127 552 3436683
SGTC_393 acivicin 6.25 µM 1.24660203834178 0.102651787608312 no 388 0.106271726983734 535 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.24314493540676 0.103264935150415 no 389 0.106907214824224 567 616764
SGTC_918 glabranin 770.725 nM 1.24229419666113 0.103416228005687 no 390 0.107064017881843 596 124049 Also referred to as licorice root.
SGTC_474 dl-dihydrosphingosine 5 µM 1.24148148630195 0.103560908214059 no 391 0.107213966630577 596 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_123 0083-0120 66.675 µM 1.24117430416728 0.103615631582895 no 392 0.107270682544568 615 16001701
SGTC_3097 9117246 49.47 µM 1.24006811817001 0.103812868380656 no 393 0.107475100017472 568 16423892
SGTC_898 1000-0849 28.3 µM 1.23963278168988 0.103890565016942 no 394 0.10755562489317 598 6751807
SGTC_994 3910-0338 138 µM 1.23903418805703 0.103997467810555 no 395 0.107666418679208 625 3479481
SGTC_1276 0871-0068 94.2 µM 1.23486554306183 0.104744158432072 no 396 0.108440274583752 556 3414906
SGTC_1208 2323-2347 50.3 µM 1.23409831800634 0.104882006307251 no 397 0.108583135114179 601 5412760
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.23110106182407 0.10542178427816 no 398 0.109142534233601 563 641818 YHR062C RPP1
SGTC_2792 7535235 81.82 µM 1.23093952434731 0.105450932637127 no 399 0.10917274182176 554 1281891
SGTC_908 3448-7491 47.7 µM 1.2303012097454 0.105566169270942 no 400 0.109292165739847 685 1203031
SGTC_3033 9090887 49.47 µM 1.22881576062834 0.105834693840409 no 401 0.109570445494902 625 19325384
SGTC_2446 5162541 200 µM 1.22800965255875 0.105980620446185 no 402 0.109721672251032 565 1549321
SGTC_3191 9110352 49.47 µM 1.22480916271865 0.106561427200014 no 403 0.110323565929859 571 17122424
SGTC_3007 9078383 71.4286 µM 1.22180545100697 0.10710861071039 no 404 0.110890603356681 610 6496995
SGTC_2517 totarol 10 µM 1.22105032050747 0.107246490351931 no 405 0.111033483914291 548 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2774 tamoxifen 10.92 µM 1.21883983803719 0.107650838903922 no 406 0.111452493857735 589 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1955 wogonin 32.4 µM 1.21820496687942 0.107767174353775 no 407 0.111573046332028 575 5281703 A flavanone.
SGTC_1607 st000305 50.6 µM 1.21652440934617 0.108075561192141 no 408 0.111892609196684 611 5457690
SGTC_660 4031-1742 102 µM 1.21613315387144 0.108147448714057 no 409 0.111967101391479 642 6738706
SGTC_2730 imipramine 71.33 µM 1.21535627324142 0.108290291284699 no 410 0.112115118902401 706 3696 A tricyclic antidepressant.
SGTC_1052 3253-3998 198 µM 1.21288167147856 0.108746193404571 no 411 0.112587532045732 654 5450317
SGTC_2227 7312221 64.1025 µM 1.21073356300839 0.109143062542153 no 412 0.112998767387708 576 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2673 kobusone 100 µM 1.2103879115991 0.109207019709118 no 413 0.113065039130184 596 6710676 An epoxy ketone and protein crosslinker.
SGTC_3276 9139060 49.47 µM 1.20013256610207 0.111116871158139 no 414 0.115043929780838 570 4870619
SGTC_2878 9043973 25.97 µM 1.19371623367721 0.112323881114393 no 415 0.116294494069612 590 6465167
SGTC_409 arachidonic acid 100 µM 1.19192741449145 0.112662049197358 no 416 0.116644853853181 628 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2424 5537928 59.2 µM 1.19140892808368 0.112760202452959 no 417 0.116746544849675 672 5382802
SGTC_655 k060-0012 42 µM 1.18921454815172 0.113176290584906 no 418 0.11717762555674 620 5994525
SGTC_527 4476-4215 268 µM 1.18912037098331 0.113194172506126 no 419 0.117196151639575 641 4418754
SGTC_403 arphamenine a 50 µM 1.18651812919556 0.113689071616778 no 420 0.117708873171925 627 5487158 An arginine aminopeptidase inhibitor.
SGTC_944 3370-0224 231 µM 1.18533434198444 0.113914716132697 no 421 0.11794264020899 627 4580514
SGTC_557 1315-0110 16.2 µM 1.18420162562807 0.114130924499633 no 422 0.118166629397006 641 6833801
SGTC_735 3076-0345 636 µM 1.18344945464585 0.114274657281635 no 423 0.118315533677929 689 2888990
SGTC_1195 1502-0147 41.1 µM 1.18265218663954 0.114427148351643 no 424 0.11847351040836 659 817940
SGTC_3006 9075424 71.4286 µM 1.18228325522033 0.114497761768192 no 425 0.118546663711673 588 7465181
SGTC_2712 st079126 47.7 µM 1.17952301679463 0.115027055248971 no 426 0.119094988518651 590 3152970
SGTC_1076 itraconazole 331 nM 1.1741705047036 0.116058387384193 no 427 0.120163368833961 648 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1831 st055328 12 µM 1.17411603421322 0.116068916491192 no 428 0.120174275938313 662 1103068
SGTC_2154 5570129 200 µM 1.1667430645255 0.11750036876936 no 429 0.121657072995057 683 673366
SGTC_2070 5230947 200 µM 1.15789430143952 0.119234790239135 no 430 0.123453586664427 668 2835538
SGTC_962 1254-0300 21.5 µM 1.15731068191264 0.119349815781364 no 431 0.123572725438542 648 7340576
SGTC_2869 9037858 32.47 µM 1.15637831146777 0.119533739057859 no 432 0.123763224466703 598 27187042
SGTC_2990 9074105 71.4286 µM 1.15577869375714 0.119652127734044 no 433 0.123885845065164 611 6502001
SGTC_1358 1509-0022 2.48 µM 1.15469154632472 0.119866985247017 no 434 0.124108381291269 660 3258434
SGTC_2258 7960471 200 µM 1.15320776960613 0.120160669024613 no 435 0.124412557614499 551 2974708
SGTC_444 curcumin 90.4 µM 1.15185422896598 0.120429017087642 no 436 0.124690489696439 693 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2271 7849410 118.62 µM 1.15082219860333 0.120633907092812 no 437 0.124902695167149 671 972430
SGTC_1105 epirubicin 18.1 µM 1.1489645525924 0.121003325585781 no 438 0.125285298782032 643 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_278 4092-0821 23.9 µM 1.14587122598347 0.12162024101593 no 439 0.125924219292548 662 877900
SGTC_2402 5553605 200 µM 1.14547359773233 0.121699701775655 no 440 0.126006513140851 684 6758546
SGTC_1920 st075728 45.7 µM 1.14304546780895 0.12218572308789 no 441 0.126509856854875 660 3400306
SGTC_1723 st034307 2.5525 µM 1.14032676800865 0.122731520912535 no 442 0.127075094918949 658 867466
SGTC_400 oxethazaine 37.5 µM 1.13850057801048 0.123099099958717 no 443 0.127455758827652 640 4621 A local anesthetic.
SGTC_971 1315-0384 26.7 µM 1.13849881649872 0.123099454891321 no 444 0.127456126391986 646 6769120
SGTC_2389 9091542 195.52 µM 1.13648946503297 0.123504792688295 no 445 0.127875886069549 698 3626624 YOL127W RPL25
SGTC_2043 5101342 149 µM 1.13588205506595 0.123627506681198 no 446 0.128002964745762 668 678451
SGTC_1396 3511-0007 98.6 µM 1.13540211085886 0.123724529352123 no 447 0.128103437828804 601 X1396
SGTC_2945 9067681 61.76 µM 1.13415916820652 0.123976043023439 no 448 0.12836389407581 646 16456930
SGTC_2036 5160441 105 µM 1.13366336656964 0.124076469933139 no 449 0.128467890863354 761 134534 YIL048W NEO1
SGTC_1711 st032263 62.8 µM 1.13314274523408 0.124181985438689 no 450 0.128577156636569 634 3958979
SGTC_2992 9074591 71.4286 µM 1.1320032797784 0.124413142482036 no 451 0.128816527768473 653 17741321
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.13129852647354 0.124556262386413 no 452 0.128964732169465 621 521171
SGTC_2635 hydroquinidine 100 µM 1.12479586368081 0.125882241694649 no 453 0.130337773821931 691 442912 An experimental heart treatment.
SGTC_2235 salicylic acid 500 µM 1.12443317839142 0.125956486803593 no 454 0.130414651690845 681 338 A COX inhibitor and kinase inhibitor.
SGTC_1013 4112-3890 241 µM 1.12301084687849 0.126247946173407 no 455 0.13071644386721 694 705171
SGTC_1438 4092-1045 4 µM 1.12079797882584 0.126702333546987 no 456 0.131186932349173 692 1351342
SGTC_781 4335-2806 94.4 µM 1.11732638289624 0.127417478978532 no 457 0.131927399447085 790 845254
SGTC_2007 4011539 71.82 µM 1.1160162395716 0.127688095479404 no 458 0.132207591674505 684 45595301
SGTC_320 4092-0846 5.34 µM 1.11596459669213 0.127698770746665 no 459 0.132218644614827 692 1359356
SGTC_3169 9102970 49.47 µM 1.11453474503224 0.127994586424677 no 460 0.132524923647189 691 17027839
SGTC_303 1348-1668 34.2 µM 1.11438017431428 0.128026593367012 no 461 0.132558062469194 678 5380509
SGTC_852 0418-0143 439 µM 1.11370692049295 0.128166068814977 no 462 0.132702469709555 777 5369229
SGTC_2526 patulin 37.61 µM 1.11294523190712 0.128323992151275 no 463 0.132865976053219 747 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2359 9039622 200 µM 1.11292155147692 0.128328904055326 no 464 0.132871061587413 736 6463596
SGTC_190 3970-0790 3.722 µM 1.10968306980133 0.129001874832569 no 465 0.133567810452139 665 2832352
SGTC_580 1123-0028 41 µM 1.10864896425007 0.129217281112908 no 466 0.133790823210181 783 1677248 YPR107C YTH1
SGTC_2005 4024620 188 µM 1.10729212546988 0.129500291384096 no 467 0.134083823901023 691 236743
SGTC_307 1501-1223 22.3 µM 1.10726084858452 0.129506820195986 no 468 0.134090583139249 690 2830329
SGTC_1316 1272-0050 65.9 µM 1.1070661791029 0.129547461096161 no 469 0.134132658364701 692 7340392
SGTC_2943 9068529 45.32 µM 1.10525724526318 0.129925532432329 no 470 0.134524069123438 745 3270634
SGTC_2982 9019404 25.97 µM 1.10415604026093 0.130156060492539 no 471 0.13476272756392 575 22333232
SGTC_3258 9138477 49.47 µM 1.10386164636581 0.130217737313136 no 472 0.134826579209485 695 4970355
SGTC_2970 9090938 41.86 µM 1.10199550453704 0.130609172639288 no 473 0.135231813000488 782 17217104
SGTC_3120 9124077 49.47 µM 1.09920678621708 0.131195639365157 no 474 0.135838939688143 716 18774327 YGL155W CDC43
SGTC_342 k048-0088 23.3 µM 1.09904204731174 0.131230340719001 no 475 0.135874862986128 686 6820570
SGTC_2344 7990960 76.95 µM 1.09637784324214 0.131792421124747 no 476 0.136456728064563 680 140813
SGTC_1670 st016595 4.04 µM 1.0951539119191 0.132051196016672 no 477 0.136724606533344 716 597879
SGTC_1062 mesoridazine 14.2 µM 1.093012493089 0.132504796981679 no 478 0.137194157275812 719 4078 A neuroleptic.
SGTC_210 3551-0445 56.827 µM 1.09286268975349 0.132536568848053 no 479 0.137227045955459 713 2865180 YOR207C RET1
SGTC_1258 0671-0043 57.1 µM 1.09139116817403 0.132848943635867 no 480 0.137550398469293 699 4298767
SGTC_3290 9121031 71.43 µM 1.09030829946527 0.133079138695936 no 481 0.137788680247551 651 17014854
SGTC_2264 7948757 110.76 µM 1.08860744948051 0.133441257540414 no 482 0.138163515144916 681 2971411
SGTC_2120 5538279 151.968 µM 1.08780476121243 0.133612388784606 no 483 0.138340653596182 711 2058197
SGTC_2300 7976697 71.57 µM 1.08733546936897 0.133712510574855 no 484 0.138444289303227 609 2236109
SGTC_1226 3909-7979 35.4 µM 1.08718804706488 0.133743973256971 no 485 0.138476856113715 768 6615510
SGTC_9 0092-0002 10.449 µM 1.0863594586215 0.133920904243669 no 486 0.138659995302726 737 759368
SGTC_280 3448-3607 3.04 µM 1.08592543375641 0.134013647049258 no 487 0.138755991692747 735 626179
SGTC_3318 9139014 38.6185 µM 1.08298601748801 0.134642905472518 no 488 0.139407314714433 692 16643984
SGTC_489 paxilline 115 µM 1.08182630070401 0.134891729955465 no 489 0.139664858831114 685 105008 A toxic potassium channel blocker.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.08023790567918 0.135233041651933 no 490 0.140018126361917 686 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_214 4373-3496 70 µM 1.07985575811022 0.135315245168779 no 491 0.140103208551746 899 3779166
SGTC_1641 st009299 47.1 µM 1.07856965380713 0.135592149811296 no 492 0.140389807674324 649 4046054
SGTC_2458 5808907 16.39 µM 1.07757863649931 0.135805785408846 no 493 0.140610920156551 799 2731747
SGTC_3147 9097027 49.47 µM 1.07730082487204 0.135865715166532 no 494 0.140672946957497 763 25236841
SGTC_1444 4112-3581 28 µM 1.07717258778513 0.135893384686761 no 495 0.140701584622178 749 2877249
SGTC_2156 5649887 115 µM 1.0748580187081 0.136393459072722 no 496 0.141219149994752 811 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1664 st014217 9.02 µM 1.07037178772477 0.137366313084446 no 497 0.142225996477784 800 3982782
SGTC_1816 st051957 91.6 µM 1.06995559330669 0.137456805806991 no 498 0.1423196487609 739 674121
SGTC_2336 9001819 198.65 µM 1.06971532415203 0.13750906580785 no 499 0.142373733241816 747 2989602
SGTC_3145 9085516 49.47 µM 1.06912522210148 0.13763747414876 no 500 0.142506623956663 702 25236195
SGTC_2033 5192550 145 µM 1.0684263837833 0.137789649714907 no 501 0.142664110501062 718 182073
SGTC_3252 9135871 49.47 µM 1.06826117495196 0.137825641541881 no 502 0.142701358289401 729 17682838
SGTC_1478 0453-0656 35.7 µM 1.06732352370754 0.138030036519396 no 503 0.142912884579431 747 5258496
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.06619167984151 0.138277038058586 no 504 0.143168501240722 716 688662
SGTC_3356 9151811 4.48 µM 1.06454520725929 0.138636884358622 no 505 0.143540893206616 728 1859254 YPR165W RHO1
SGTC_522 1273-0010 11.6 µM 1.05937881304871 0.139770169257555 no 506 0.144713647352982 711 5705015
SGTC_2234 tolnaftate 200 µM 1.05914665253362 0.139821242734633 no 507 0.14476649809257 700 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_88 0180-0332 8.668 µM 1.05838690540563 0.139988469771804 no 508 0.144939543421163 741 3101745
SGTC_3156 9099931 49.47 µM 1.05703131934215 0.14028718367796 no 509 0.145248646976615 778 18111053
SGTC_2754 granisetron 64.02 µM 1.05076436585884 0.141673779763286 no 510 0.1466834128269 746 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1330 1469-0054 61.8 µM 1.04872832237705 0.142126256270065 no 511 0.147151587530632 792 7102664
SGTC_2760 etidronate 98.04 µM 1.0466595320119 0.142587010989269 no 512 0.147628317177646 706 3305 A chelator and antioxidant.
SGTC_1659 st012954 42.1 µM 1.0450463046198 0.142947004289507 no 513 0.148000784517759 734 24207262
SGTC_2481 5478948 45.16 µM 1.04417923822727 0.143140744574704 no 514 0.148201235371801 726 77792
SGTC_258 haloperidol 50.781 µM 1.04372720198317 0.14324181941284 no 515 0.14830581038749 733 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_853 0419-0306 21 µM 1.04071744246086 0.143916027347826 no 516 0.149003352770836 694 762713
SGTC_1837 st055472 66.5 µM 1.04058231897232 0.143946346112653 no 517 0.149034720338119 772 676091
SGTC_601 0986-0029 62.9 µM 1.03882010429185 0.144342143128592 no 518 0.149444204739497 792 24747981
SGTC_837 0091-0265 12.5 µM 1.0364633789019 0.144872613894157 no 519 0.149993007815002 793 759367
SGTC_361 000s-0510 1.45 µM 1.03612042469926 0.144949918062227 no 520 0.150072982322894 753 660
SGTC_671 0560-0003 407 µM 1.03529923012671 0.145135133643645 no 521 0.150264594634731 745 3238678
SGTC_1617 st002906 78 µM 1.03526910046219 0.145141932239084 no 522 0.15027162799818 787 5150859
SGTC_905 2-aminofluorene 215 µM 1.03520367420821 0.145156696056554 no 523 0.150286901629416 829 1539 An established DNA mutagen. YPR165W RHO1
SGTC_432 NS 1619 61.3 µM 1.03407770696385 0.145410935519437 no 524 0.150549918587425 702 4552 A K+/calcium channel activator.
SGTC_2015 5119600 184 µM 1.03378730734722 0.145476555293873 no 525 0.150617803323903 784 2828786
SGTC_69 0096-0274 206.684 µM 1.03189369584827 0.145904931065022 no 526 0.151060959768873 843 6741392
SGTC_2066 5222451 176 µM 1.0304946374913 0.146221972215669 no 527 0.151388934135372 824 2281147
SGTC_1865 st057639 52.2 µM 1.03016457328261 0.146296835593924 no 528 0.151466378447627 767 688818
SGTC_1769 st044406 64.4 µM 1.02999096151057 0.146336223604552 no 529 0.151507124256092 780 670903
SGTC_2031 5180455 200 µM 1.02960766780799 0.146423208221256 no 530 0.15159710716 724 29949
SGTC_2583 asiatic acid 100 µM 1.02854144345243 0.14666535957011 no 531 0.151847603246219 748 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1596 piperlongumine 63 µM 1.02674363435698 0.1470742701514 no 532 0.152270598481045 841 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2818 7996756 12.99 µM 1.02320074472426 0.147882333864115 no 533 0.153106470448316 698 2241621
SGTC_664 1222-0054 14.9 µM 1.02174502539505 0.148215214848271 no 534 0.153450797353622 784 6813991
SGTC_1301 naphtanilide LB 4.81 µM 1.0211993922829 0.148340114459822 no 535 0.153579990110019 843 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1738 st035555 74 µM 1.01875491269448 0.14890053865776 no 536 0.154159667841085 788 5331140
SGTC_464 bw-b 70c 158 µM 1.0187527934049 0.148901025141505 no 537 0.154160171031152 815 5353454
SGTC_37 0566-0070 1.56 µM 1.01563481571258 0.14961790840181 no 538 0.154901659609442 840 1626686
SGTC_999 SEC7.066 22.7 µM 1.01022007891801 0.150868324975945 no 539 0.156194930734159 841 740511 YDR170C SEC7
SGTC_35 0133-0054 64.071 µM 1.00942591684291 0.151052302832732 no 540 0.156385207141223 725 99677
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.00782065534838 0.151424637991797 no 541 0.156770284000657 824 165521
SGTC_3296 9122258 64.045 µM 1.00749543844786 0.151500145270847 no 542 0.156848374347018 782 4730474
SGTC_374 0880-0231 82.3 µM 1.00228895463339 0.152712369414817 no 543 0.158102027800091 810 6833587
SGTC_1655 st012546 55.1 µM 0.999783681641898 0.153297957911735 no 544 0.158707602302638 772 720985 YLR208W SEC13
SGTC_316 k060-0003 58.6 µM 0.999208979678369 0.153432499635172 no 545 0.158846733393915 782 6152314
SGTC_2664 lyso-paf C-16 73.48 µM 0.999056792305017 0.153468140851358 no 546 0.158883590214277 838 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2655 perillic acid 100 µM 0.99762619956538 0.153803443679159 no 547 0.159230325885712 762 5702197 An apoptosis inducer.
SGTC_2319 6033012 152.6 µM 0.996369119455582 0.154098478510671 no 548 0.159535415709468 741 847246
SGTC_727 3032-0951 202 µM 0.995067243572058 0.154404421233835 no 549 0.159851780392489 778 3652836
SGTC_974 1326-0144 138 µM 0.9935039670005 0.154772323770267 no 550 0.160232209101016 826 5411856
SGTC_1451 4152-0210 104 µM 0.990633739403797 0.15544931164687 no 551 0.160932228301704 841 659563
SGTC_3220 9131269 49.47 µM 0.990204972723769 0.1555506104265 no 552 0.161036971237496 803 17722206
SGTC_1432 4049-0298 68.4 µM 0.986312386555992 0.156472249787058 no 553 0.161989921663532 814 741646
SGTC_1844 rapamycin 4 nM 0.986064303283411 0.156531109575341 no 554 0.162050779598147 884 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1611 st001856 99.4 µM 0.983454773916007 0.157151124843884 no 555 0.162691831836593 793 647478
SGTC_411 enrofloxacin 100 µM 0.983199055451527 0.157211969444565 no 556 0.162754739792916 846 71188 A bacterial gyrase inhibitor.
SGTC_463 ikarugamyin 104 µM 0.982212704256346 0.157446802876747 no 557 0.162997535047675 807 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2164 5685496 200 µM 0.98028032696344 0.157907536943362 no 558 0.163473881476279 830 759046
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.980066307259338 0.157958619768841 no 559 0.163526694598511 1036 16725076
SGTC_2026 5148700 152 µM 0.979684001951363 0.158049896474497 no 560 0.163621062721146 825 79838
SGTC_1788 fluconazole 20 µM 0.979357059733816 0.158127982513074 no 561 0.163701793078665 773 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.978605975501725 0.158307465428163 no 562 0.163887352816172 752 1241132 A phosphatase inhibitor.
SGTC_2566 crystal violet carbinol 226 nM 0.976782204079833 0.15874383926457 no 563 0.164338494046565 686 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_452 diindolylmethane 8 µM 0.975169755632357 0.159130306016941 no 564 0.164738030889123 761 3071 Inhibits expression of several cancer promoting factors.
SGTC_2112 5488546 200 µM 0.974015109827616 0.159407426394244 no 565 0.165024518465678 820 600757
SGTC_244 nsc-207895 1.295 µM 0.969555627481165 0.160480687838837 no 566 0.166134019851908 720 42640
SGTC_2529 gangaleoidin 93.61 µM 0.968660367661745 0.160696717283962 no 567 0.166357336405217 848 4565183
SGTC_410 α-linolenic acid 100 µM 0.968165586696162 0.160816191171741 no 568 0.166480839324023 862 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_87 0100-0052 35.5 µM 0.965986594655123 0.161343038447058 no 569 0.167025444483331 1021 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_3158 9100007 49.47 µM 0.965685500173099 0.161415926957139 no 570 0.167100788607427 760 19297233
SGTC_2093 5331342 194.4 µM 0.963425279036553 0.161963763460444 no 571 0.167667072674548 852 33839
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.959772982743062 0.16285157049533 no 572 0.168584741299937 792 4620898
SGTC_3122 9126309 49.47 µM 0.959351308112973 0.162954275346169 no 573 0.168690897936694 901 17591206
SGTC_379 3970-0972 5.9 µM 0.95858412218481 0.163141242365702 no 574 0.168884147244783 835 2898042 YBL034C STU1
SGTC_525 k781-2675 26.7 µM 0.956309704300331 0.163696348263553 no 575 0.169457894270079 856 3651118 YDL195W SEC31
SGTC_730 1436-0052 41.2 µM 0.955659136758909 0.163855354320882 no 576 0.169622236904339 817 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.951128288598915 0.164965523583858 no 577 0.170769628004915 902 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2200 6600604 21.907 µM 0.947837252109177 0.165774955058266 no 578 0.171606156423765 858 2904777
SGTC_2448 5185112 27.17 µM 0.94668950471976 0.166057846743654 no 579 0.171898510020013 772 5718189
SGTC_3140 9094243 49.47 µM 0.946439152474172 0.166119593868761 no 580 0.171962321834992 935 19291112
SGTC_1751 st044839 27.194 µM 0.944988659914074 0.166477636672754 no 581 0.172332332761277 858 5291326
SGTC_405 ebelactone b 50 µM 0.944662237269175 0.166558280184995 no 582 0.172415670950702 859 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3247 9135149 49.47 µM 0.941725346208492 0.167284980050428 no 583 0.173166637418884 819 8934436 YOR116C RPO31
SGTC_2294 7971431 200 µM 0.940889792672973 0.167492100993308 no 584 0.173380669499958 766 5741572
SGTC_1516 st013856 110 µM 0.938589493476013 0.168063163100501 no 585 0.173970774579365 823 5281404 A mutagen and neurotoxin.
SGTC_1496 4469-0713 57.4 µM 0.938374473367983 0.168116607001125 no 586 0.174025999747809 853 746691
SGTC_1726 st035556 14.5795 µM 0.938078491802466 0.168190192002758 no 587 0.174102037060311 908 5919439
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.937462500882365 0.1683434020648 no 588 0.174260352094684 851 140250 A respiratory chain inhibitor.
SGTC_3070 9117005 49.47 µM 0.934741092842743 0.169021348069532 no 589 0.17496087203314 835 8779016
SGTC_2690 usnic acid 100 µM 0.933764754252211 0.169264996341212 no 590 0.175212627095971 931 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2308 7584454 197.62 µM 0.933040860213441 0.16944579179234 no 591 0.175399435981194 907 893577
SGTC_1553 gossypol 38.6 µM 0.93249821135156 0.169581401767184 no 592 0.175539555310158 792 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_832 4083-0019 164 µM 0.931400472604682 0.169855943602216 no 593 0.175823223250659 1028 1990758
SGTC_1363 1636-0063 10.4 µM 0.930193563616398 0.170158117371432 no 594 0.176135436900702 905 6072185
SGTC_1287 0971-0001 34.6 µM 0.929242905064746 0.170396376102027 no 595 0.176381608394116 918 4665869
SGTC_1293 1000-1278 195 µM 0.929176567858878 0.170413009831055 no 596 0.176398794427027 891 678847
SGTC_2732 terfenadine 20 µM 0.927994790466354 0.170709508989142 no 597 0.176705135967861 859 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2513 baicalein 25.65 µM 0.927764797785299 0.17076725080379 no 598 0.176764793982299 859 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2622 2-methoxyxanthone 59.94 µM 0.926142437780894 0.17117491447788 no 599 0.177185981063162 937 71034 A hepatoprotective.
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.925924628219463 0.171229692614313 no 600 0.177242575660314 872 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1868 st057644 42.7 µM 0.925762468142408 0.171270482430748 no 601 0.177284717973768 946 688665
SGTC_75 0159-0059 199.013 µM 0.925356491639341 0.171372629180349 no 602 0.177390251277059 865 5377270
SGTC_2592 piperlongumine 83.33 µM 0.924460297850273 0.171598256128131 no 603 0.177623356596138 815 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2540 epiandrosterone 100 µM 0.924219097073172 0.171659013558801 no 604 0.177686127347037 1056 441302 A steroid.
SGTC_431 k089-0097 107 µM 0.921583571154241 0.172323786411822 no 605 0.178372915595576 913 5499420
SGTC_2727 riluzole 51.77 µM 0.918879883337773 0.173007456398357 no 606 0.179079201544456 834 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_33 0986-0033 35.816 µM 0.918683689745995 0.173057134189584 no 607 0.17913052168949 853 2848082
SGTC_3029 9088683 49.47 µM 0.918032512890247 0.173222082515513 no 608 0.179300922255498 884 25236615
SGTC_1764 st044502 93.5 µM 0.917035381835167 0.173474857780454 no 609 0.17956204991346 897 8407
SGTC_6 0844-0013 19.835 µM 0.916117032675195 0.173707869205824 no 610 0.179802757570584 1086 1584900
SGTC_3273 9137859 49.47 µM 0.914252158889796 0.174181653345889 no 611 0.180292181319035 900 2377234
SGTC_1122 capsaicin 818.572 nM 0.913394260919377 0.174399883832309 no 612 0.180517611436172 905 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1207 2099-0101 141 µM 0.912636720934799 0.174592729779491 no 613 0.180716817371472 958 5837381
SGTC_2240 6690706 185.951 µM 0.912079124573283 0.174734762828121 no 614 0.180863533307484 775 805876
SGTC_3316 9136639 10.545 µM 0.911848670060806 0.174793486487685 no 615 0.18092419278516 888 4903665
SGTC_707 0865-0008 204 µM 0.911371583964142 0.174915095800054 no 616 0.181049810328947 957 723043
SGTC_2896 9052656 71.43 µM 0.911255379532621 0.174944724455331 no 617 0.181080415418378 930 6469436
SGTC_2652 actinonin 100 µM 0.911136815161603 0.174974958106743 no 618 0.181111645392142 874 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1386 3228-0095 33.8 µM 0.910270120977752 0.175196063882669 no 619 0.181340035974429 872 870181
SGTC_2857 9024691 58.44 µM 0.907713285770755 0.175849380132125 no 620 0.182014861371559 862 16478292
SGTC_2555 cholic acid 100 µM 0.906973095609544 0.176038799345525 no 621 0.182210512429843 893 6708657 Influences liver metabolism.
SGTC_876 0720-0963 56.8 µM 0.906516707947394 0.176155656109887 no 622 0.182331212763379 937 765861
SGTC_2293 7624732 200 µM 0.906185225446076 0.176240562037386 no 623 0.182418910882326 858 894453
SGTC_2283 7944793 200 µM 0.904873458749473 0.176576811934979 no 624 0.182766214678482 914 2970533
SGTC_914 3820-6779 408 µM 0.903658210143349 0.176888682784297 no 625 0.183088332393987 903 2893481
SGTC_1578 josamycin 24.2 µM 0.903285116001515 0.17698450022819 no 626 0.183187296945602 828 5282165 A P450 substrate.
SGTC_1106 tegaserod maleate 11.7 µM 0.903255001892031 0.17699223551601 no 627 0.183195286275451 920 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2231 micatex 6.853 µM 0.903167067284337 0.177014824140722 no 628 0.183218616735945 919 20737 An antifungal of unknown mechanism.
SGTC_978 1416-0512 87.4 µM 0.90277489193597 0.177115588242679 no 629 0.183322689699692 927 6814003
SGTC_2674 ligustilide 100 µM 0.901755150324928 0.177377766488143 no 630 0.183593474639623 884 5319022 A signalling regulator.
SGTC_3154 9100113 49.47 µM 0.900150707688665 0.177790768665937 no 631 0.184020026973383 906 25237525
SGTC_1425 4048-4433 7.33 µM 0.898591324115744 0.17819275291849 no 632 0.184435190802753 951 23734946
SGTC_3355 9151058 44.0485 µM 0.896891628807009 0.178631559254986 no 633 0.184888373725967 914 17015728
SGTC_2735 sertaconazole 140 nM 0.896519606786497 0.17872769399529 no 634 0.184987656693463 900 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_814 3342-0569 96 µM 0.894924253532302 0.179140320753935 no 635 0.185413790341319 927 4346283
SGTC_1502 4534-4282 27.7 µM 0.894592111781148 0.179226302160406 no 636 0.185502585062517 882 3278949
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.893266882634672 0.179569622033981 no 637 0.185857134269588 994 551469
SGTC_2557 derrustone 83.84 µM 0.893089785825667 0.179615532824259 no 638 0.185904546215706 974 629853 An antioxidant.
SGTC_1144 3486-0183 12.5 µM 0.892682729365532 0.179721086591435 no 639 0.186013550853447 940 6744069
SGTC_681 1642-0006 26.6 µM 0.892331586225339 0.179812172785271 no 640 0.186107614429961 927 4446530
SGTC_211 3455-0679 143.504 µM 0.89221905347034 0.179841369808787 no 641 0.186137765734131 928 748649
SGTC_2450 5739737 12.93 µM 0.891899644393417 0.17992425785009 no 642 0.186223362643669 865 2262825
SGTC_285 1486-1325 46 µM 0.88668580791108 0.181280661656482 no 643 0.18762404064666 945 22310230
SGTC_2334 9017922 200 µM 0.883695369680396 0.182061520057817 no 644 0.188430340272781 947 3163164
SGTC_3059 1327-0034 3 µM 0.883646414644883 0.182074320587072 no 645 0.188443557572789 894 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1119 parthenolide 318.541 nM 0.882768959287092 0.182303848844695 no 646 0.188680557451725 982 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_469 w7 172 µM 0.882097356361219 0.182479651507319 no 647 0.188862080857964 918 45115570 A P450 inhibitor.
SGTC_840 0245-0196 390 µM 0.879058381016527 0.183276474315334 no 648 0.189684811096614 974 3827528
SGTC_2376 9072922 81.32 µM 0.877840008366878 0.183596541415082 no 649 0.190015274628983 948 17087968
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.876443122220541 0.183963932429233 no 650 0.190394592150703 1000 5106787 A p450 inhibitor.
SGTC_2726 cimetidine 79.27 µM 0.876171165602895 0.184035512160802 no 651 0.190468494670183 950 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2887 9044784 58.44 µM 0.875281134055456 0.184269892130342 no 652 0.190710478334974 1022 6465546
SGTC_2610 ononetin 44.17 µM 0.872431529034079 0.185021552736031 no 653 0.191486503242811 923 259632
SGTC_1770 st043884 66.3 µM 0.869642830588562 0.18575898904915 no 654 0.192247811818883 982 670149
SGTC_136 0097-0015 404.482 µM 0.868707589254838 0.186006709577212 no 655 0.19250354465536 1042 4861337
SGTC_520 3584-0023 682 µM 0.868087009394087 0.186171197644728 no 656 0.192673351032228 875 1340790
SGTC_2972 9093619 59.92 µM 0.867062957655495 0.186442825176028 no 657 0.192953757609116 900 25236256
SGTC_481 bay k-8644 50 µM 0.866912218084988 0.186482829240608 no 658 0.192995054258872 885 2303 A calcium channel antagonist.
SGTC_1213 1315-0166 115 µM 0.865675664935445 0.186811192899097 no 659 0.193334024366108 823 768401
SGTC_870 0573-2213 57.6 µM 0.865175321407225 0.186944159526813 no 660 0.19347128420188 972 3916321
SGTC_1373 2887-0003 58.5 µM 0.863439312969514 0.187405958825915 no 661 0.193947986232239 911 776948
SGTC_605 1315-0399 119 µM 0.862606525204316 0.18762774051898 no 662 0.194176920748167 991 24020461
SGTC_346 4513-0042 7.16 µM 0.862397325762148 0.187683478393978 no 663 0.194234455822272 950 2827372
SGTC_2109 5483026 200 µM 0.861497408456684 0.187923363714643 no 664 0.194482073937788 962 759335
SGTC_3298 9116858 71.43 µM 0.861170125506135 0.188010652404146 no 665 0.194572175601131 971 2506942
SGTC_2179 6298986 200 µM 0.861053475981236 0.188041769710889 no 666 0.194604295592666 923 738374
SGTC_1914 st062367 72.6 µM 0.860853478890927 0.188095128125398 no 667 0.194659373233383 902 978205
SGTC_1591 genipin 88.4 µM 0.859557660503842 0.188441073610218 no 668 0.195016461276662 925 442424 A DNA cross-linking agent.
SGTC_3272 9137413 49.47 µM 0.859341198562287 0.188498900824005 no 669 0.195076150384037 969 17614870
SGTC_1255 0566-0045 221 µM 0.859176691792263 0.188542855673936 no 670 0.195121520344561 957 2788469
SGTC_1829 berberine 14.4 µM 0.857600502015292 0.188964320864503 no 671 0.195556548880125 958 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_358 0075-0058 9.45 µM 0.85448847114662 0.189798164786734 no 672 0.196417197300184 1019 1069125
SGTC_2779 methotrexate 400 µM 0.851532796831886 0.19059220569766 no 673 0.197236726390427 1050 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_269 exalamide 29 µM 0.849672256700708 0.19109308346727 no 674 0.197753663496445 952 3316 A derivative of salicylamide.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.847813413344969 0.191594309701699 no 675 0.198270945893568 1125 688664
SGTC_741 4582-0002 126 µM 0.846809687834627 0.191865292920724 no 676 0.198550603743064 948 2912688
SGTC_2418 pentamidine 31.67 µM 0.844095285070917 0.192599294756881 no 677 0.19930808110935 963 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2729 fluphenazine 10.66 µM 0.842222879312108 0.193106610977177 no 678 0.199831604751335 1002 3372 An atypical antipsychotic.
SGTC_3019 9081971 49.47 µM 0.842151351078098 0.193126007253595 no 679 0.199851620395004 1034 16451803
SGTC_1826 st055655 41.6 µM 0.840497553763093 0.193574798260547 no 680 0.200314736292873 984 676168
SGTC_2233 sulbentine 40.3845 µM 0.839291175385798 0.193902574055716 no 681 0.200652967007701 1011 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2572 astragaloside iv 100 µM 0.839251723338686 0.193913298976871 no 682 0.200664033912679 962 45006101 An anti-inflammatory agent.
SGTC_433 pimozide 108 µM 0.838932027014127 0.194000220801538 no 683 0.200753727155693 901 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3115 9123671 49.47 µM 0.837456522168724 0.194401701479115 no 684 0.201168003022607 1061 3286988
SGTC_787 4152-0075 138 µM 0.836225807905418 0.1947369619306 no 685 0.201513941124168 975 9566539
SGTC_1753 st043925 64 µM 0.834090722125018 0.195319417131014 no 686 0.202114931456571 1023 670181
SGTC_2307 7538926 6.34 µM 0.833617082918527 0.195448770046695 no 687 0.20224839804368 987 96582
SGTC_1177 0983-0204 23.6 µM 0.833313883171792 0.195531602517076 no 688 0.202333864239597 1035 766818
SGTC_3274 9138298 49.47 µM 0.83228919665081 0.195811698855159 no 689 0.202622863538613 1032 17015756
SGTC_736 0958-0254 92.6 µM 0.831722643314147 0.195966669740809 no 690 0.202782758285128 1032 6812352
SGTC_995 3931-2021 34.6 µM 0.831137292181768 0.196126860567026 no 691 0.202948037368626 947 730143
SGTC_281 1672-3440 14.9 µM 0.830787471743338 0.196222632501118 no 692 0.203046850669002 1035 6833000
SGTC_567 1080-0542 68.4 µM 0.830625870398822 0.196266884410686 no 693 0.203092507678587 938 5950415
SGTC_1027 k015-0025 8.67 µM 0.830480368729717 0.196306732860855 no 694 0.203133621312109 994 3598955
SGTC_2951 9072950 58.06 µM 0.830016758781534 0.196433734131544 no 695 0.203264654245952 1081 16488155
SGTC_2947 9072639 7.68 µM 0.829845833485867 0.196480569953717 no 696 0.203312976639216 1074 16488146
SGTC_1703 st026983 48.3 µM 0.829813528143172 0.196489422810962 no 697 0.203322110472317 1029 1104023
SGTC_2358 9037157 4 µM 0.828453880380265 0.196862235655845 no 698 0.203706751706385 993 2388925
SGTC_2438 5259590 200 µM 0.82720741342044 0.197204390558324 no 699 0.204059755234909 1032 1201127
SGTC_952 1185-0122 232 µM 0.826478618065033 0.19740461129726 no 700 0.20426632118792 1014 678600
SGTC_579 4491-1009 110 µM 0.826390947462904 0.197428705177283 no 701 0.204291178473088 1187 1271041
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.824992183224458 0.197813357954433 no 702 0.20468801427554 1022 688798
SGTC_124 0136-0217 7.121 µM 0.824500654503296 0.197948633197512 no 703 0.204827572027687 1153 3976905
SGTC_2452 5863136 48.41 µM 0.824309529777839 0.198001248348407 no 704 0.204881852569467 1013 2184096
SGTC_3146 9095609 49.47 µM 0.823298343554199 0.198279760581575 no 705 0.205169177687369 982 17173999
SGTC_578 3460-0051 92 µM 0.823097706274036 0.198335050447596 no 706 0.205226216540738 1102 2876744
SGTC_277 nystatin 15.5 µM 0.821928940143438 0.198657313715085 no 707 0.205558670455093 1057 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_476 mead acid 10 µM 0.821910456795955 0.198662412653795 no 708 0.205563930584676 996 5312531 An omega 9 fatty acid.
SGTC_2 0422-0095 29 µM 0.82152429455688 0.198768959976225 no 709 0.205673845803612 924 6790840
SGTC_1951 sophoraflavanone G 9.2 µM 0.820219889012488 0.19912911755536 no 710 0.206045382873143 1011 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2885 9057732 51.95 µM 0.816760346020359 0.200086229259984 no 711 0.2070326987663 1041 6471414
SGTC_2331 7980721 200 µM 0.81647391517561 0.20016559653036 no 712 0.207114568291514 1023 2981221
SGTC_1046 2001-0062 216 µM 0.816462424453644 0.200168780895139 no 713 0.207117853043843 966 739778
SGTC_2113 5491891 107.031 µM 0.816361955125212 0.200196624741158 no 714 0.207146574645943 1038 789979
SGTC_2725 haloperidol 53.21 µM 0.815725572454553 0.200373044476847 no 715 0.207328554832263 1025 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_336 4111-0029 111 µM 0.815107958509073 0.2005443503675 no 716 0.207505258262043 957 3131175
SGTC_768 0384-0033 77.3 µM 0.814658921845441 0.200668953636245 no 717 0.207633786482418 990 3965305 YMR134W ERG29
SGTC_3066 9117245 49.47 µM 0.814292458038343 0.200770678182371 no 718 0.20773871464014 1053 17176980
SGTC_1934 st074720 32.6 µM 0.813361826933986 0.201029145691822 no 719 0.208005319359209 1084 17250992
SGTC_1805 st050013 60.3 µM 0.811866673532367 0.201444817688623 no 720 0.208434069602386 987 4037144
SGTC_1424 4048-1941 275 µM 0.810845981420898 0.201728878914165 no 721 0.208727062428282 1099 X1424
SGTC_357 1325-0123 420 µM 0.808541171331865 0.202371195279791 no 722 0.209389557492713 1022 1098503
SGTC_2213 7173844 200 µM 0.806189676975102 0.203027780717067 no 723 0.210066745014604 1058 892728
SGTC_1898 st060199 18.6 µM 0.805707574184797 0.203162550664018 no 724 0.21020574060642 1057 688866
SGTC_1452 4194-0072 190 µM 0.804466173864576 0.203509824974047 no 725 0.210563898638278 1082 1343545
SGTC_2506 ethyl hematommate 54.16 µM 0.803432955441623 0.203799131452544 no 726 0.2108622667182 962 3940691 An allergen.
SGTC_368 fentichlor 4.58 µM 0.797029910187952 0.205597477462991 no 727 0.21271683025362 988 7329 A pesticide.
SGTC_696 1560-0013 611 µM 0.797015424772293 0.205601556457219 no 728 0.212721036544474 1044 1650269
SGTC_3032 9089427 49.47 µM 0.793843694899824 0.206495850328523 no 729 0.213643215813525 1038 17173707
SGTC_1149 3909-7961 23.3 µM 0.79302524002688 0.20672699353335 no 730 0.213881558760654 1028 735261
SGTC_97 0535-0701 19.132 µM 0.792680867325657 0.206824295014722 no 731 0.213981890088463 1019 2832013 YGL099W LSG1
SGTC_108 0509-0257 621.132 µM 0.79083609123007 0.20734599242461 no 732 0.214519823004409 1049 536624
SGTC_1186 1319-0216 26 µM 0.790825865286575 0.207348886458894 no 733 0.214522807057935 1108 4565136
SGTC_2304 7443016 91.4 µM 0.79081754260993 0.207351241869112 no 734 0.214525235733074 979 939854
SGTC_633 0437-0093 97.7 µM 0.790000188169505 0.207582639338751 no 735 0.214763829217434 1083 2831118
SGTC_599 1935-0052 86.5 µM 0.789475279335222 0.207731324305264 no 736 0.214917136335483 1089 9557311
SGTC_1349 flufenamic acid 69 µM 0.789400283365916 0.207752572697153 no 737 0.214939045167213 994 3371 A non-steroidal anti-inflammatory.
SGTC_2180 6301957 200 µM 0.788991189752224 0.207868502612182 no 738 0.21505857793283 1062 845462
SGTC_516 3992-2719 87.3 µM 0.788459619564871 0.208019197283813 no 739 0.215213954684666 1060 5350887 YDR037W KRS1
SGTC_2429 5902844 64.44 µM 0.787651527058306 0.208248406681108 no 740 0.215450283046921 1088 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1525 8-methoxypsoralen 92.5 µM 0.787609508037635 0.208260329136312 no 741 0.215462575714337 1114 4114 Related to psoralen; DNA damaging agent.
SGTC_1113 artemisinin 1.17947 µM 0.787537703150182 0.208280703950032 no 742 0.215483583180765 1090 2240 An anti-malaria and mitochondrial poison.
SGTC_502 l-744,832 89.3 µM 0.786983410476886 0.20843802543509 no 743 0.215645788787546 1062 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_348 k064-0012 10.7 µM 0.786005212599673 0.208715832233835 no 744 0.215932216668073 1011 5066323
SGTC_3094 9117742 49.47 µM 0.782350947742637 0.209755566746345 no 745 0.217004176467381 1085 17149698
SGTC_1733 st037357 54.9 µM 0.779994805785102 0.210427562851003 no 746 0.2176969662724 1090 1272339 YGL099W LSG1
SGTC_3203 9113543 49.47 µM 0.778555535932926 0.210838678573104 no 747 0.21812079005163 1047 17018012
SGTC_1277 0873-0036 22 µM 0.778122062263039 0.210962589035052 no 748 0.218248528765094 1101 5965735
SGTC_2049 5262831 67.185 µM 0.775714690740085 0.2116515239278 no 749 0.218958731922369 1059 763417
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.773447008229748 0.212301685900903 no 750 0.219628939380404 1120 6728940
SGTC_1238 0333-0287 48.8 µM 0.773213167423446 0.212368796177512 no 751 0.219698117340931 1095 7226
SGTC_970 1315-0089 19.5 µM 0.772875934824533 0.21246560082519 no 752 0.219797904092294 1059 6811083 YLR033W RSC58
SGTC_2259 7964009 200 µM 0.771714540396099 0.21279918329269 no 753 0.220141758430668 1025 313134
SGTC_2211 7117706 200 µM 0.769423738854703 0.21345805617293 no 754 0.220820900291522 1050 822771
SGTC_773 4358-1457 44.6 µM 0.767117997562104 0.214122425080824 no 755 0.221505681112906 1130 1186886
SGTC_1100 amiodarone 5.07 µM 0.766752255848481 0.2142279191878 no 756 0.221614413978958 1116 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.766123855063665 0.214409244957103 no 757 0.221801305055521 1089 2333 A French combination drug.
SGTC_1721 st082152 9.2685 µM 0.764571213330909 0.214857644009639 no 758 0.222263458101241 1069 5296051
SGTC_479 n-linoleoylglycine 10 µM 0.764328281063497 0.214927851492249 no 759 0.222335818012007 1092 6433346 An anti-infammatory.
SGTC_1715 st032160 10.2275 µM 0.762112113069641 0.215568939501268 no 760 0.222996546965977 1040 5289825
SGTC_2495 cafestol 54.53 µM 0.761124819106726 0.215854898321739 no 761 0.223291258767743 1107 16667697 An anti-infammatory.
SGTC_2844 9010103 25.97 µM 0.76047709311868 0.216042624379641 no 762 0.223484728322627 1060 2480525
SGTC_169 k015-0017 16.025 µM 0.760000428382827 0.216180833292823 no 763 0.223627164405814 1090 1840002
SGTC_2663 amphotericin b 100 µM 0.757311245743349 0.216961520259555 no 764 0.22443170753448 1093 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1494 4358-1428 177 µM 0.756058005181192 0.21732589996054 no 765 0.224807209442714 1151 1564571
SGTC_949 1165-0505 146 µM 0.755401303978065 0.217516976859884 no 766 0.225004115535547 1116 6244267
SGTC_2114 5491910 81.25 µM 0.752929489335679 0.218237056611664 no 767 0.225746143156269 1107 2849228
SGTC_732 3970-1727 52.7 µM 0.751794400767645 0.218568186007633 no 768 0.226087354873306 1109 1275699
SGTC_2658 polymyxin b sulfate 77.05 µM 0.749021026523078 0.21937845375148 no 769 0.226922266142792 1100 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_428 3448-4153 16.5 µM 0.747977056999401 0.219683905980846 no 770 0.227236998184386 1086 3834874
SGTC_752 1896-0090 130 µM 0.747595607946246 0.219795574016489 no 771 0.227352057359579 1109 772567
SGTC_835 0312-0010 67.2 µM 0.744592886185951 0.220675748588175 no 772 0.228258934874914 1093 1626196
SGTC_2989 9073649 71.4286 µM 0.743680587746589 0.22094356594793 no 773 0.228534868095586 1139 21367202
SGTC_3204 9114183 49.47 µM 0.743581981046919 0.22097252439578 no 774 0.228564703833395 1119 17027248
SGTC_2824 7998404 51.95 µM 0.742704105665286 0.221230431311938 no 775 0.228830421757434 1071 837851
SGTC_1385 3091-4834 14.1 µM 0.741856765693275 0.221479530599806 no 776 0.229087061501802 1071 4072814
SGTC_843 0310-0051 143 µM 0.741788223632299 0.221499687463304 no 777 0.229107828368005 1147 2065037
SGTC_810 3825-7150 143 µM 0.738199385187982 0.222556557784545 no 778 0.230196648220712 1183 22330411 YGL099W LSG1
SGTC_817 1391-0715 46 µM 0.737615170859857 0.222728873678698 no 779 0.230374166893209 1088 1353946
SGTC_172 1112-0046 2.638 µM 0.737320768137499 0.222815737513307 no 780 0.230463652750714 1038 2802135 YIL048W NEO1
SGTC_761 k216-0224 480 µM 0.737250928379366 0.222836346640173 no 781 0.230484883906258 1172 1340404
SGTC_652 0437-0092 114 µM 0.736645563150611 0.22301503034408 no 782 0.230668959601672 1114 3091274
SGTC_546 peri-Naphthalide 147 µM 0.736516279134923 0.223053201262004 no 783 0.230708282122194 1094 223824 A penicillin ester.
SGTC_1387 3342-1166 1.8 µM 0.735777678231471 0.223271343436315 no 784 0.230933003877733 1087 3418228
SGTC_553 k007-0256 45.7 µM 0.734803974063449 0.223559107678308 no 785 0.231229443237612 1168 6287000
SGTC_1662 st014054 52 µM 0.733425600013902 0.223966826710751 no 786 0.231649445050872 1160 2838777
SGTC_1171 0368-0077 21.4 µM 0.733055476398579 0.224076380111405 no 787 0.231762297100558 1104 3239779
SGTC_500 h-89 112 µM 0.733017930615403 0.224087495039952 no 788 0.231773746658659 1156 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3236 9132701 49.47 µM 0.730188095549823 0.224926130797628 no 789 0.232637609092099 1132 24282524
SGTC_600 1495-0418 41.6 µM 0.728739656402135 0.225356070372719 no 790 0.233080465002511 1149 5377768
SGTC_2703 st077852 53.4 µM 0.725962375510825 0.226181749599396 no 791 0.233930918043261 1120 6281836
SGTC_1626 st003712 1.76 µM 0.722603518733388 0.227182609943794 no 792 0.234961752906577 1119 24207035
SGTC_253 dyclonine 31.25 µM 0.721886495103462 0.227396588991205 no 793 0.23518213246564 1210 3180 An oral anasthetic.
SGTC_501 nsc-95397 161 µM 0.721482332803719 0.227517251859254 no 794 0.235306403357699 1152 262093
SGTC_614 0462-0418 107 µM 0.720943735329254 0.227678106448819 no 795 0.235472066395412 1043 5188303
SGTC_594 1487-1584 10.8 µM 0.720251781734721 0.227884855468397 no 796 0.235684993480985 1150 5013332
SGTC_2095 5432005 200 µM 0.717818590763816 0.228612707511713 no 797 0.236434574477999 1163 783734
SGTC_823 0417-1665 178 µM 0.717425372735172 0.228730455123147 no 798 0.236555834241176 1183 3429856
SGTC_2085 5307070 144.047 µM 0.711545405855126 0.230495244432861 no 799 0.23837316208606 1138 2840351
SGTC_1423 4048-0112 5.59 µM 0.711444649779026 0.230525551128486 no 800 0.238404369365625 1184 X1423
SGTC_709 3807-1509 243 µM 0.711000573074745 0.230659152710808 no 801 0.238541940340678 1195 1886677 YPL242C IQG1
SGTC_1296 1068-0102 11.9 µM 0.705335884735958 0.232367178767223 no 802 0.240300616876368 1138 767053
SGTC_530 4358-1714 28 µM 0.703713035496849 0.232857796289383 no 803 0.240805750364367 1178 1564641
SGTC_3091 9116372 49.47 µM 0.703290634863137 0.232985590187525 no 804 0.240937322897149 1197 17169793
SGTC_811 0416-0114 265 µM 0.701128436590475 0.233640355430179 no 805 0.241611432662326 1203 6612453
SGTC_1778 st046819 58.9 µM 0.698543236263391 0.234424553148393 no 806 0.242418764276206 1235 671715
SGTC_1280 0880-0253 10.1 µM 0.698481797440222 0.234443207774076 no 807 0.242437968755207 1183 6836607
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.698436506085245 0.234456960081502 no 808 0.242452126404276 1153 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_602 3130-1533 38.1 µM 0.698377671565139 0.234474825314127 no 809 0.242470518187393 1206 720941
SGTC_2728 chlorpromazine 9.18 µM 0.696113868926174 0.235162805723373 no 810 0.243178760855782 1193 2726 A thorazine and dopamine antagonist.
SGTC_1787 fluconazole 80 µM 0.694561234160777 0.235635302579236 no 811 0.243665156743005 1128 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1050 3232-1156 69.3 µM 0.694419234095105 0.235678542072173 no 812 0.243709667489033 1159 700529
SGTC_1212 0520-0165 585 µM 0.692846151590953 0.236157843577365 no 813 0.24420305288697 1304 5403258
SGTC_877 0771-0151 33.1 µM 0.690922285154332 0.236744754364494 no 814 0.244807190319749 1197 6166523
SGTC_2996 9066192 71.4286 µM 0.690857734771681 0.236764460544139 no 815 0.244827474534985 1209 6472854
SGTC_1744 st037937 38.9 µM 0.688585302900663 0.23745877152003 no 816 0.24554213625585 1252 1016152
SGTC_268 camptothecin 39.6153 µM 0.688468702611367 0.237494427290689 no 817 0.245578836320064 1209 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1159 4092-0538 61.2 µM 0.684508917521584 0.238707052188174 no 818 0.246826930125484 1253 717301
SGTC_747 3448-8087 38.7 µM 0.684188165726391 0.238805425725573 no 819 0.246928177077465 1225 5168703
SGTC_1867 st057372 64 µM 0.684014811044624 0.238858602275497 no 820 0.246982906624146 1219 688837
SGTC_1860 st056228 74.6 µM 0.683854594475519 0.238907754467404 no 821 0.247033494127895 1198 688679
SGTC_1253 0550-0034 176 µM 0.682921562875749 0.239194105319306 no 822 0.247328203851372 1182 5969915
SGTC_699 0375-0592 111 µM 0.682389958211775 0.239357340591563 no 823 0.247496201858512 1248 762578
SGTC_1915 st067105 30.6 µM 0.682034689527869 0.239466463801259 no 824 0.247608508050241 1215 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_40 0327-0103 19.753 µM 0.680544945447876 0.239924344554023 no 825 0.248079736560115 1155 409036
SGTC_680 0417-1641 114 µM 0.67790607571958 0.240736585863253 no 826 0.248915623725746 1208 2835990
SGTC_1214 0358-0031 63.7 µM 0.677306620690687 0.240921305846214 no 827 0.249105715548758 1260 4301366
SGTC_2785 7756463 72.73 µM 0.675906093731305 0.241353173674941 no 828 0.249550134270724 1216 2201551
SGTC_586 0957-0265 8.15 µM 0.67530591541527 0.241538373896299 no 829 0.249740713217289 1139 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_667 1498-1044 59 µM 0.674134857183743 0.241899955659998 no 830 0.250112790181613 1250 6739982
SGTC_165 k038-0023 64.381 µM 0.673394127041098 0.242128818713913 no 831 0.250348291977176 1227 46368543
SGTC_188 3229-0966 278.469 µM 0.672965797479259 0.242261213054652 no 832 0.250484525260579 1317 5722370
SGTC_827 3253-0474 693 µM 0.672640958589647 0.24236164514622 no 833 0.250587868782872 1232 5402065
SGTC_515 4092-1064 102 µM 0.672553673364252 0.242388635408145 no 834 0.250615641360038 1258 717353
SGTC_879 0831-1030 162 µM 0.672390627281736 0.242439056738733 no 835 0.250667524036385 1258 1549252
SGTC_1615 st002656 86.5 µM 0.67231347566459 0.242462917539403 no 836 0.2506920763322 1237 1584458
SGTC_1181 1222-0449 220 µM 0.67223081299284 0.242488484164098 no 837 0.25071838384824 1282 658318
SGTC_895 0964-0006 13.7 µM 0.671953822065311 0.242574164952867 no 838 0.250806547271651 1215 6738897
SGTC_1380 2291-0730 164 µM 0.671022342018525 0.242862417165539 no 839 0.251103148358506 1224 2999191
SGTC_552 k242-0005 476 µM 0.670079278566608 0.243154442651636 no 840 0.251403626742964 1256 4088318
SGTC_1503 4585-0012 61.3 µM 0.669293549517836 0.243397893471459 no 841 0.251654120379554 1257 2922052
SGTC_2254 7938975 95.19 µM 0.669271381245033 0.243404764013936 no 842 0.251661189627285 1291 2969277
SGTC_2949 9072542 2.23 µM 0.665667169953186 0.244523198052711 no 843 0.252811931124527 1255 16457352
SGTC_1928 4'-methoxychalcone 40.3 µM 0.664404616384878 0.24491563872387 no 844 0.253215689513007 1278 641818
SGTC_1148 3909-7663 27.7 µM 0.66433505420316 0.244937270646764 no 845 0.2532379450066 1298 4084526
SGTC_2177 5811945 192 µM 0.664123190749093 0.245003160679983 no 846 0.253305734233345 1282 5343475
SGTC_2755 lomerizine 42.69 µM 0.664007346289491 0.245039192611886 no 847 0.253342804623869 1260 3949 A calcium channel blocker.
SGTC_1233 0325-0408 14.2 µM 0.663452940295989 0.245211672936955 no 848 0.253520254799117 1276 12874
SGTC_3257 9139206 32.98 µM 0.663299805602863 0.245259325919216 no 849 0.253569280528096 1217 4910041
SGTC_2215 7188065 200 µM 0.663083166373175 0.245326748965042 no 850 0.253638645598058 1261 940217
SGTC_353 1988-1175 58.3 µM 0.661902436123155 0.245694394076797 no 851 0.254016875213836 1172 2788357
SGTC_1999 st074831 12.5 µM 0.66107472104115 0.245952296800819 no 852 0.254282197927436 1237 17112523
SGTC_1457 k015-0032 57.3 µM 0.660334967175962 0.246182915095729 no 853 0.254519447710875 1255 4302660
SGTC_1324 1418-0026 34.4 µM 0.658823407669783 0.246654504151404 no 854 0.255004587096734 1282 1372513
SGTC_425 3825-7017 13.1 µM 0.657849966071467 0.246958462577585 no 855 0.255317271904535 1320 3397440
SGTC_1986 st071812 45 µM 0.656613358439811 0.247344883810629 no 856 0.255714778620815 1238 11838594
SGTC_1170 0310-0127 64.8 µM 0.656157969946307 0.247487267231301 no 857 0.255861244321835 1245 774975
SGTC_2880 9042983 58.44 µM 0.656019709112554 0.247530505031228 no 858 0.255905721543459 1273 6464714
SGTC_2677 mitomycin C 100 µM 0.655102033613343 0.247817588563419 no 859 0.25620103142774 1265 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2581 avocatin a 64 µM 0.655038130542155 0.24783758647374 no 860 0.256221602184307 1263 6710728 A skin care supplement.
SGTC_1426 4048-4480 71.7 µM 0.653410776314495 0.248347143000773 no 861 0.256745746672826 1259 14224343
SGTC_2930 9013230 14.89 µM 0.653340408849951 0.248369189023586 no 862 0.256768423478807 1248 2995857
SGTC_1569 carminic acid 40.6 µM 0.653086938638881 0.24844860951248 no 863 0.256850116103032 1258 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3165 9101544 49.47 µM 0.652888642661304 0.248510751547932 no 864 0.256914035680383 1256 5002184
SGTC_2134 5324836 1.464 µM 0.652724110628859 0.248562318917061 no 865 0.256967077924814 1235 699272
SGTC_2698 st077697 67.5 µM 0.650883328298582 0.24913964246771 no 866 0.257560902104039 1212 3154499
SGTC_1807 st050092 58.9 µM 0.650469479435001 0.249269535791301 no 867 0.257694505063801 1234 5008496
SGTC_2442 5158906 48.48 µM 0.649868094189793 0.249458354678943 no 868 0.257888714562888 1289 1893835
SGTC_3016 9080866 49.47 µM 0.64844997696276 0.249903906347646 no 869 0.258346977476198 1265 17066299
SGTC_2767 sibutramine 71.45 µM 0.648410327278159 0.249916369765041 no 870 0.25835979628627 1332 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3074 9116018 49.47 µM 0.648153087539838 0.249997238098958 no 871 0.258442970333192 1310 17027303
SGTC_2417 cerulenin 830 nM 0.646960552865673 0.250372315977871 no 872 0.258828737045268 1345 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2957 9076800 11.52 µM 0.645823396747415 0.250730253755778 no 873 0.259196866970804 1216 16459615
SGTC_443 clozapine 122 µM 0.644933787327499 0.251010461117801 no 874 0.25948504752166 1199 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1147 3809-1045 12.3 µM 0.643847574906353 0.25135281863655 no 875 0.259837139993096 1233 325925
SGTC_1044 1222-0021 1.78 µM 0.643009901373587 0.251617008989885 no 876 0.260108837577214 1274 4306703
SGTC_3112 9123419 49.47 µM 0.642575775935797 0.251753983681924 no 877 0.260249702813875 1313 17015854
SGTC_695 3505-6186 243 µM 0.641930856981266 0.251957540338428 no 878 0.260459038988839 1296 1819379
SGTC_36 0335-0881 14.2 µM 0.641145074273706 0.252205675352013 no 879 0.260714215695307 1232 23828853
SGTC_1775 st081588 35.1725 µM 0.636907239467218 0.253546120341592 no 880 0.262092633453649 1304 1426443 YGL099W LSG1
SGTC_1134 3477-0009 42.5 µM 0.635097510066973 0.254119683735744 no 881 0.262682410445558 1381 3973534
SGTC_157 1348-1695 65.819 µM 0.634206404389779 0.254402354589193 no 882 0.262973064260386 1294 5380510
SGTC_1234 0326-0494 15.5 µM 0.634080226516169 0.254442393243295 no 883 0.26301423324618 1346 1547813
SGTC_1085 doxorubicin 7.67 µM 0.63342261188339 0.254651120392508 no 884 0.26322885133567 1304 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_592 k241-0073 46.5 µM 0.632424025668676 0.254968243447002 no 885 0.263554919343154 1312 4230158
SGTC_377 3970-0964 33.1 µM 0.631931145451823 0.255124844552527 no 886 0.263715935286577 1306 16481235
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.630862620320874 0.255464515965546 no 887 0.264065177261783 1308 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1130 3454-2858 15.9 µM 0.630056468614732 0.255720938289698 no 888 0.264328819698224 1286 715628 YIL048W NEO1
SGTC_470 aa-861 153 µM 0.629945187984221 0.255756345204624 no 889 0.26436522324316 1259 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2427 5545055 42.75 µM 0.629724831899914 0.255826464949518 no 890 0.264437316477204 1331 5372858
SGTC_318 1488-0629 67.2 µM 0.629210065397594 0.255990308439936 no 891 0.264605770058509 1296 3662576
SGTC_1278 0874-0585 172 µM 0.627894190877621 0.256409382907946 no 892 0.265036628369836 1287 766306
SGTC_1657 st012939 43.4 µM 0.627334759312141 0.256587656680271 no 893 0.265219911607072 1333 24207257
SGTC_842 0271-0008 11.1 µM 0.626946664439254 0.256711368590894 no 894 0.265347098621037 1357 1221709
SGTC_3113 9123498 49.47 µM 0.625296643729936 0.257237687525686 no 895 0.265888191180011 1340 8897275
SGTC_3285 9112818 20.8695 µM 0.625139332240377 0.257287895572947 no 896 0.265939807636696 1324 17017947 YPR165W RHO1
SGTC_815 1582-0027 36.9 µM 0.624938818979094 0.257351899421446 no 897 0.266005606655628 1339 3128206
SGTC_2487 5918373 44.05 µM 0.623978350529635 0.257658595725634 no 898 0.266320901531537 1337 2876279
SGTC_3109 9122853 49.47 µM 0.623425894959482 0.257835091493693 no 899 0.266502342853092 1375 1234709
SGTC_1006 4099-6547 255 µM 0.622910994306547 0.257999645872686 no 900 0.26667150639997 1323 3146833
SGTC_2469 5655019 90.81 µM 0.620281025217337 0.258840992713964 no 901 0.267536392534795 1402 2788239
SGTC_54 0159-0055 9 µM 0.619067457447215 0.259229700279921 no 902 0.267935960236419 1394 3319099
SGTC_2297 7971671 152.32 µM 0.61809897779804 0.259540122070869 no 903 0.268255048040881 1366 909016
SGTC_1304 1165-0502 251 µM 0.617214257568983 0.259823864559864 no 904 0.268546706386393 1325 767425
SGTC_938 3126-1755 342 µM 0.616931502551653 0.259914581894266 no 905 0.268639953476679 1321 1777771
SGTC_754 3474-0146 171 µM 0.61651643503632 0.260047779123105 no 906 0.268776864113915 1243 24762078
SGTC_2689 tacrolimus 100 µM 0.616408135761262 0.260082538687461 no 907 0.268812592555405 1324 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_2800 7887935 81.82 µM 0.616312348593755 0.260113284381655 no 908 0.26884419518138 1331 2961002
SGTC_909 3448-9333 149 µM 0.615232755622732 0.260459940855126 no 909 0.269200509368271 1297 3344074
SGTC_2611 pyromycin 23.93 µM 0.615082243093055 0.260508289203096 no 910 0.269250204075154 1301 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.614922223131918 0.260559696641099 no 911 0.269303042895655 1376 6710655
SGTC_1282 0886-0010 32.4 µM 0.613379622838282 0.261055534584584 no 912 0.269812678261356 1369 2836211 YNL267W PIK1
SGTC_2467 5474540 200 µM 0.613169850314482 0.26112299920498 no 913 0.269882018975405 1296 5413519
SGTC_1109 tnp00067 928.257 nM 0.612966784499987 0.261188315425904 no 914 0.269949151270129 1295 676295
SGTC_2428 5615643 7.78 µM 0.612197729300127 0.261435758503062 no 915 0.270203471873465 1342 2253075
SGTC_1259 0671-0132 43 µM 0.611867481021699 0.261542052633845 no 916 0.270312719186553 1301 X1259
SGTC_2181 6316240 54.2555 µM 0.610769566452762 0.261895588222573 no 917 0.270676071919871 1301 12779990
SGTC_2459 5811157 9.22 µM 0.610705891937002 0.261916099344296 no 918 0.270697152359858 1287 2870684 YBR192W RIM2
SGTC_2170 morpholine 200 µM 0.610705629962118 0.261916183734527 no 919 0.270697239092416 1381 121171 Reacts with secondary amines.
SGTC_880 0833-0487 87.2 µM 0.609575095806374 0.262280493644381 no 920 0.271071656525548 1292 76075
SGTC_2807 7945238 51.95 µM 0.608611235726532 0.262591298384974 no 921 0.271391077639562 1364 17148797
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.60727395018796 0.26302282923516 no 922 0.271834561514562 1500 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3334 9142812 21.919 µM 0.605282670582435 0.263666069500962 no 923 0.272495596916395 1382 45283678
SGTC_2279 7948423 32.93 µM 0.604701890202982 0.263853829217149 no 924 0.272688545994335 1428 1247112
SGTC_997 3996-0078 137 µM 0.603165755637926 0.264350772499142 no 925 0.273199213084242 1350 735687
SGTC_1352 1496-0991 99 µM 0.602371551349014 0.264607886249489 no 926 0.27346342120908 1331 3000039
SGTC_3110 9122132 49.47 µM 0.600497225159262 0.265215179968585 no 927 0.27408745481342 1419 918317
SGTC_3222 9128301 49.47 µM 0.598662624899292 0.265810286834783 no 928 0.274698942750708 1351 4911358
SGTC_1209 2323-2347 50.3 µM 0.598286751785786 0.265932295883522 no 929 0.274824307453179 1329 5412760
SGTC_1007 4101-0031 70 µM 0.595303874123395 0.266901548031865 no 930 0.275820183379038 1339 1146276
SGTC_27 0485-0001 32.618 µM 0.594619106720492 0.26712430701185 no 931 0.276049052677016 1301 2054479
SGTC_1054 3429-0080 167 µM 0.594052383428602 0.267308736484646 no 932 0.276238538674986 1387 1162877
SGTC_2623 humulene 100 µM 0.593696258526019 0.267424663521386 no 933 0.276357642980734 1298 6187145 An anti-inflammatory.
SGTC_1746 st038117 42 µM 0.589474818106698 0.268800770711164 no 934 0.277771399925819 1368 2898218
SGTC_2838 9002687 71.43 µM 0.589013365440268 0.268951410629597 no 935 0.277926153908155 1336 6457060
SGTC_1612 st002233 45.4 µM 0.588222118599094 0.269209809525997 no 936 0.278191606432294 1361 1035021
SGTC_622 1348-1566 26.3 µM 0.585588690983881 0.270070708686607 no 937 0.279075974951481 1423 7340407
SGTC_2395 5646831 180.19 µM 0.585382907804568 0.270138039658396 no 938 0.279145139452634 1415 6808628
SGTC_120 rhodamine 6G 52.259 µM 0.583908624063541 0.270620661518684 no 939 0.279640895330035 1355 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_442 cape 100 µM 0.58128879087545 0.271479351935803 no 940 0.28052291695779 1418 5281787
SGTC_2638 epoxomicin 18 µM 0.579172294327858 0.272174055798997 no 941 0.281236461619691 1403 9915668 A protesome inhibitor.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.578162581553627 0.27250578782396 no 942 0.281577179438579 1376 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2010 4012422 159 µM 0.577726797410385 0.272649022769199 no 943 0.281724292065937 1405 952393
SGTC_1310 1188-0297 994 nM 0.577705261494436 0.272656102232686 no 944 0.281731563151579 1331 1588352
SGTC_2854 9024559 71.43 µM 0.577331190756046 0.272779084396354 no 945 0.281857873597325 1327 3163529
SGTC_263 alizarin 107.927 µM 0.576972278813982 0.272897108709986 no 946 0.281979091099719 1389 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1393 3470-5649 58.2 µM 0.576010553102651 0.273213486611244 no 947 0.282304024276532 1334 4108395
SGTC_86 0417-1630 471.922 µM 0.575960859759384 0.273229839114461 no 948 0.282320818797251 1390 3634867
SGTC_1783 st039459 87.517 µM 0.575170936805051 0.273489842800485 no 949 0.282587848209968 1496 729761
SGTC_2788 5282734 71.43 µM 0.57460090732941 0.273677544443961 no 950 0.282780619144667 1496 743706
SGTC_2255 7941087 197.44 µM 0.57453190032123 0.273700271678443 no 951 0.282803960022988 1454 935561
SGTC_2643 anethole 100 µM 0.573905576084643 0.273906592218076 no 952 0.283015849766798 1364 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2966 9084041 48.03 µM 0.569939332809059 0.275214914175519 no 953 0.2843594231215 1273 17741380
SGTC_2713 st079149 53.4 µM 0.569721689408761 0.275286795905342 no 954 0.284433238419844 1397 3103253
SGTC_1879 gemcitabine 100 µM 0.567700436821307 0.275954802047752 no 955 0.285119197451954 1383 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1342 1486-1464 234 µM 0.562467488047989 0.277687935431791 no 956 0.286898774434894 1397 3253938
SGTC_1456 k015-0012 13 µM 0.562129163785427 0.27780016990343 no 957 0.287014009784125 1472 2989616
SGTC_549 1661-1316 519 µM 0.561389848044438 0.278045504899058 no 958 0.287265901592644 1445 2857282
SGTC_485 niflumic acid 177 µM 0.561000638354775 0.27817470294323 no 959 0.287398551006034 1429 4488 A COX2 inhibitor.
SGTC_300 r073-0011 5.04 µM 0.560661864411687 0.278287182682809 no 960 0.2875140346221 1424 2735780
SGTC_2380 9035439 200 µM 0.557754843978949 0.279253282121045 no 961 0.288505900765836 1475 6462575
SGTC_3295 9122362 53.5725 µM 0.557232790482083 0.279426950318822 no 962 0.288684194404744 1391 4730473
SGTC_703 3875-0075 71.8 µM 0.554161863426757 0.280449596526228 no 963 0.289734037714296 1466 2850814
SGTC_448 monastrol 171 µM 0.553404815512407 0.28070197835468 no 964 0.289993121110564 1409 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3167 9103034 49.47 µM 0.550566137251887 0.281649303438613 no 965 0.290965563731234 1416 5127859
SGTC_3000 9075062 71.4286 µM 0.550336473777145 0.281726014201061 no 966 0.291044305852837 1398 17057871
SGTC_1993 st073995 70.8 µM 0.54974483471127 0.281923676175436 no 967 0.2912472002959 1439 3098394
SGTC_2822 7994718 71.43 µM 0.547852267673761 0.282556416288921 no 968 0.291896673023257 1425 1018011
SGTC_3148 9097893 49.47 µM 0.547587719431851 0.282644916804315 no 969 0.291987511821959 1305 17174100
SGTC_168 3970-0862 530.542 µM 0.547424288343236 0.282699596799292 no 970 0.292043636268173 1424 3135186
SGTC_2654 protoveratrine a 100 µM 0.547230526848139 0.282764431182144 no 971 0.292110183091905 1399 5702278 A heart drug and vasodilator.
SGTC_2242 6630449 61.2675 µM 0.546161348616528 0.283122316481065 no 972 0.292477516106663 1429 691249 YDR170C SEC7
SGTC_776 4476-4378 112 µM 0.545347018284179 0.283395042452879 no 973 0.292757436073727 1414 2892008
SGTC_1153 4055-0057 267 µM 0.544941091218491 0.283531037812121 no 974 0.292897016915462 1375 882706
SGTC_2600 tangeritin 87.95 µM 0.544696949623318 0.283612846194054 no 975 0.292980981571396 1357 68077 A bioactive flavone.
SGTC_1017 4239-0030 168 µM 0.544606986946489 0.283642994260609 no 976 0.293011924158725 1376 1149593
SGTC_1774 st048371 48.465 µM 0.542431158491367 0.284372619593464 no 977 0.293760759863368 1380 4242727
SGTC_32 0928-0142 34.1 µM 0.542251229928789 0.284432995560512 no 978 0.293822723913353 1393 2244242
SGTC_947 3447-0010 211 µM 0.541424101444255 0.284710621592913 no 979 0.294107649333928 1414 748350
SGTC_2054 5233173 129 µM 0.540170995592635 0.285131473366124 no 980 0.294539556579616 1456 6889
SGTC_2478 5763493 32.33 µM 0.535981682219544 0.286540590017881 no 981 0.295985605163146 1462 1365576 YLR208W SEC13
SGTC_1901 st060216 58.6 µM 0.534183099743248 0.287146572848429 no 982 0.296607430291133 1419 688792
SGTC_1893 st059353 36.1 µM 0.534120327554893 0.2871677331609 no 983 0.296629143364856 1384 3112488
SGTC_64 000l-0018 272.079 µM 0.532566517462346 0.287691752917811 no 984 0.297166842464598 1451 6811119
SGTC_2316 5844804 197.44 µM 0.531946928665937 0.287900834105597 no 985 0.297381376601503 1477 776813
SGTC_67 0335-0847 266 µM 0.529723551620146 0.288651706210156 no 986 0.298151808144722 1681 4552207 YOR254C SEC63
SGTC_986 1493-0483 84 µM 0.528672714451389 0.28900691243597 no 987 0.298516254195159 1416 40079
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.527376108518885 0.289445477121827 no 988 0.298966215610263 1401 6708760
SGTC_755 1995-0008 37.3 µM 0.527320856752152 0.289464172451353 no 989 0.298985396483033 1432 689533
SGTC_1348 1493-0373 93.8 µM 0.527136841412376 0.289526441109549 no 990 0.299049282177247 1464 3010129
SGTC_2734 clemastine 41.6 µM 0.52684699290862 0.289624535238892 no 991 0.299149923165193 1450 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_3056 9094900 49.47 µM 0.526806073542937 0.289638384935337 no 992 0.299164132395971 1363 25236784
SGTC_913 3487-1245 167 µM 0.526320724721764 0.289802681322096 no 993 0.299332692907533 1378 4016153
SGTC_2895 9054447 58.44 µM 0.5251728329045 0.290191430334176 no 994 0.299731524369257 1456 2697450
SGTC_1049 3226-0134 66 µM 0.525066338618352 0.290227508438658 no 995 0.299768537676725 1454 5702385
SGTC_2100 5377183 190 µM 0.52298279033563 0.290933794684561 no 996 0.30049311471414 1536 2844202
SGTC_77 0828-0286 12.516 µM 0.52251006631349 0.291094151541775 no 997 0.300657619769494 1400 745345
SGTC_2920 7982904 15.77 µM 0.522272368390931 0.291174798730787 no 998 0.300740352542192 1419 6456808
SGTC_1025 k007-0731 70 µM 0.521799414187418 0.29133529572083 no 999 0.30090499880102 1429 6256118
SGTC_1636 st007707 68.9 µM 0.517709677241523 0.292724866674302 no 1000 0.302330422662055 1531 403051
SGTC_2653 dihydrofissinolide 100 µM 0.517535119818243 0.292784244524267 no 1001 0.302391329701172 1474 6857746
SGTC_2267 7931562 200 µM 0.51683324500987 0.293023052286949 no 1002 0.302636285251037 1352 934880
SGTC_692 k241-0027 77.8 µM 0.51682879922965 0.293024565219068 no 1003 0.302637837119547 1536 3600480
SGTC_948 3448-0295 75.3 µM 0.516412329800785 0.293166308935167 no 1004 0.302783228039803 1460 678569
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.516072546555285 0.293281976358716 no 1005 0.302901870713863 1427 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.514954519564727 0.293662719104176 no 1006 0.303292400843325 1595 136420
SGTC_2423 st077119 87.2 µM 0.514601017565772 0.293783151374053 no 1007 0.30341592695046 1397 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1506 4226-2149 212 µM 0.506780628170578 0.29645325303892 no 1008 0.306154375050092 1519 991114
SGTC_1141 3253-0389 52.6 µM 0.506321608318561 0.296610320367803 no 1009 0.306315448086157 1470 5402031
SGTC_340 k038-0059 454 µM 0.506315413617435 0.296612440330163 no 1010 0.306317622102963 1505 23733424
SGTC_1210 3013-0140 750 nM 0.505735610270241 0.296810892447719 no 1011 0.306521132996937 1596 905973
SGTC_3057 9095946 49.47 µM 0.505728221457382 0.296813421844853 no 1012 0.306523726854468 1492 24540043
SGTC_2531 methyl deoxycholate 70.07 µM 0.504139388317803 0.297357552836145 no 1013 0.307081714859666 1445 16667744 Haematoxylin.
SGTC_1896 st058441 89 µM 0.503102519588137 0.297712896974859 no 1014 0.307446097678222 1424 688759
SGTC_1809 st050081 57.6 µM 0.503057326350381 0.297728389504828 no 1015 0.307461984091463 1543 5036894
SGTC_273 hydroxyurea 18.1 mM 0.50169743831903 0.298194739731956 no 1016 0.307940183365783 1499 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_965 1291-5240 308 µM 0.500388312587776 0.29864399593854 no 1017 0.30840084060215 1578 2834598
SGTC_1552 6-methylflavone 10.6 µM 0.499864935715645 0.298823690667682 no 1018 0.30858509178291 1492 689013
SGTC_2695 st077686 51.995 µM 0.499388965274936 0.298987151652721 no 1019 0.308752695718168 1440 2876092
SGTC_3302 9125395 16.351 µM 0.49796539555439 0.29947628576021 no 1020 0.309254216387712 1522 17599668
SGTC_279 1273-0055 2.93 µM 0.497148101549457 0.299757269244073 no 1021 0.309542308129166 1531 2847562
SGTC_1771 st048882 4.1505 µM 0.49425627372137 0.30075242907209 no 1022 0.31056260092743 1424 4580403
SGTC_3238 9133470 49.47 µM 0.49005851546733 0.302199642706783 no 1023 0.312046246218004 1574 3534688
SGTC_1061 3448-9325 110 µM 0.489620705174936 0.302350761438509 no 1024 0.312201161086879 1481 723482
SGTC_2024 5144227 134 µM 0.489373612418811 0.302436065267274 no 1025 0.312288607092793 1551 3475211
SGTC_936 3005-4620 401 µM 0.489257950693448 0.302475998870995 no 1026 0.312329543354702 1599 777207
SGTC_2224 6650123 117.647 µM 0.488935482823377 0.302587347268655 no 1027 0.312443686939075 1486 2908370
SGTC_1838 st055369 84.5 µM 0.485993714198103 0.303603989191356 no 1028 0.313485811314264 1468 676036
SGTC_803 4488-1585 147 µM 0.484828817549401 0.304006985366261 no 1029 0.313898889556513 1553 747204
SGTC_195 4234-0266 16.654 µM 0.4843355691099 0.304177696575177 no 1030 0.314073868297974 1484 2303354
SGTC_2683 piperine 63.03 µM 0.483275305653239 0.304544793778672 no 1031 0.314450135780641 1492 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2028 5153890 36.43 µM 0.483187268041793 0.304575284083319 no 1032 0.314481387342493 1490 2830968 YPR165W RHO1
SGTC_3067 9117431 49.47 µM 0.482662036056672 0.304757217310968 no 1033 0.31466786163534 1510 17150885
SGTC_1229 0139-0193 12.2 µM 0.482186426239885 0.304922003760673 no 1034 0.314836759249104 1595 3090752
SGTC_101 0490-5701 117.494 µM 0.481967162414419 0.304997986310873 no 1035 0.314914636831295 1555 4661669
SGTC_2370 9071495 200 µM 0.481002830744035 0.305332260585 no 1036 0.315257243423677 1480 21791103
SGTC_1455 4262-0120 131 µM 0.480824772669969 0.305394000099485 no 1037 0.315320521073239 1582 1529587
SGTC_1077 5-fluorocytosine 377 nM 0.478592130682545 0.306168611507306 no 1038 0.316114408855035 1510 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1240 0356-0016 42.1 µM 0.477415738647566 0.306577107920403 no 1039 0.316533054555046 1552 4305613
SGTC_2195 6536160 144.242 µM 0.476988008490175 0.306725694764568 no 1040 0.316685330327612 1426 3834386
SGTC_629 3448-6466 76.7 µM 0.476069855298713 0.307044754246427 no 1041 0.317012306002729 1516 573744
SGTC_1895 st058434 18.3 µM 0.475766178381234 0.307150314567397 no 1042 0.317120483876236 1608 5393175
SGTC_2266 7929956 200 µM 0.475748734796827 0.307156378570621 no 1043 0.317126698224245 1498 2967153
SGTC_1638 st008370 60.6 µM 0.47463372121748 0.30754410586068 no 1044 0.317524033297406 1466 24207134
SGTC_1820 st053765 18.6 µM 0.4732649838378 0.308020355444294 no 1045 0.318012070376681 1487 3690829
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.46977039720359 0.309237756170728 no 1046 0.319259533141136 1499 688803
SGTC_1317 1273-0028 910 nM 0.468776672333964 0.309584321301355 no 1047 0.319614637951626 1511 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_129 0088-0017 176.636 µM 0.467768575486448 0.309936071796063 no 1048 0.319975047612548 1588 182446
SGTC_233 rapamycin 362 pM 0.467696960276653 0.309961066779742 no 1049 0.320000657588834 1551 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_166 k072-0058 166.424 µM 0.46680188818647 0.310273536942372 no 1050 0.320320812408805 1555 5846229
SGTC_1637 st007924 17.4 µM 0.466330667881313 0.310438095280779 no 1051 0.320489415121927 1502 683336
SGTC_2116 5511452 16.8835 µM 0.46431770242893 0.311141484870456 no 1052 0.32121007140356 1556 870744
SGTC_1608 st001473 40.5 µM 0.463819904028139 0.311315536898365 no 1053 0.321388390872154 1477 7292267
SGTC_2627 acetyl isogambogic acid 100 µM 0.463575927335831 0.311400857197275 no 1054 0.321475802322398 1467 6857789 A caspase activator and apoptosis inducer.
SGTC_2514 salinomycin 42.74 µM 0.46340274641419 0.311461425884542 no 1055 0.321537855214575 1674 23682228 A polyether potassium ionophore.
SGTC_1962 st076595 64.5 µM 0.463296155728352 0.311498707689248 no 1056 0.321576050467639 1533 279619
SGTC_883 0850-0245 24.6 µM 0.462936810572012 0.311624408670637 no 1057 0.321704830579272 1609 6823229 YPR165W RHO1
SGTC_2962 9082311 13.18 µM 0.462240327794402 0.3118681048178 no 1058 0.321954493183834 1471 16459453
SGTC_1269 0831-0796 3.05 µM 0.461042908916184 0.312287268764171 no 1059 0.322383910199926 1610 927758
SGTC_565 1418-0001 44.5 µM 0.460127613541157 0.312607837564699 no 1060 0.322712312333779 1592 2862145
SGTC_3099 9120367 49.47 µM 0.457672815311964 0.313468294435023 no 1061 0.323593760690409 1545 24824940
SGTC_847 0342-0274 5.54 µM 0.453142179578716 0.315059040688249 no 1062 0.325223182221041 1651 18097
SGTC_626 0214-0009 33 µM 0.452250087135503 0.31537266806376 no 1063 0.325544414447652 1647 3437874
SGTC_1221 2958-7315 257 µM 0.449848315941181 0.316217704732349 no 1064 0.326409908347113 1563 4562705
SGTC_2339 9000433 200 µM 0.4495515354865 0.316322190441638 no 1065 0.326516920147021 1501 2988954
SGTC_3170 9103054 49.47 µM 0.448705652369366 0.316620075870396 no 1066 0.326822003304434 1496 16432970
SGTC_2641 levomentholum 100 µM 0.446475540210591 0.317406000065946 no 1067 0.327626888609224 1547 16666
SGTC_170 4197-0004 226 µM 0.442758079385635 0.318717917966706 no 1068 0.328970363974025 1616 218692
SGTC_3050 9093513 49.47 µM 0.438467972614244 0.320234754647335 no 1069 0.330523541035995 1549 25236664
SGTC_1398 3558-0053 112 µM 0.436713642933271 0.320855894579529 no 1070 0.331159516904722 1543 4532369
SGTC_1526 st051518 75 µM 0.436713495955801 0.320855946639582 no 1071 0.331159570207124 1574 673993
SGTC_1876 myriocin 605 nM 0.435844402065146 0.321163844998519 no 1072 0.331474812946907 1670 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2883 9059145 45.46 µM 0.435650031274855 0.321232722572111 no 1073 0.331545332588286 1547 16476510
SGTC_595 3909-8003 73.7 µM 0.435320101360401 0.321349651191626 no 1074 0.331665048088108 1607 699517
SGTC_2761 levamisole 97.89 µM 0.433822863264342 0.321880501369389 no 1075 0.332208538804352 1698 26879 An alkaline phosphatase inhibitor.
SGTC_159 3970-0959 50 µM 0.431498668117787 0.322705271911796 no 1076 0.333052910418936 1628 6615653
SGTC_155 k072-0202 43.6 µM 0.43102119148092 0.322874818865383 no 1077 0.333226480965682 1560 5857737
SGTC_2466 5983409 37.09 µM 0.430784000726835 0.322959056508959 no 1078 0.333312716957428 1568 2879657
SGTC_3026 9090633 49.47 µM 0.43011457653177 0.323196849648301 no 1079 0.333556148579215 1553 25236842
SGTC_401 neomycin 50 µM 0.428793649681349 0.323666281735858 no 1080 0.334036700327071 1599 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2375 9072683 200 µM 0.427449291861967 0.324144328990115 no 1081 0.334526055782797 1727 16798029
SGTC_903 1134-0042 114 µM 0.427358581486684 0.324176595624424 no 1082 0.334559085119111 1555 701009
SGTC_2372 9071633 200 µM 0.425482317037886 0.324844298484238 no 1083 0.335242554755063 1631 21321366
SGTC_1275 0867-0008 21.1 µM 0.425238691455875 0.324931038433718 no 1084 0.335331340688683 1611 3422836
SGTC_1766 st045414 44.774 µM 0.424722005198907 0.325115029748262 no 1085 0.335519670199681 1582 253960
SGTC_656 4090-1979 187 µM 0.424393279542794 0.325232110736961 no 1086 0.335639510544628 1708 22330961
SGTC_1274 0865-0114 173 µM 0.424201769463714 0.325300328121459 no 1087 0.335709335237299 1608 870624
SGTC_3350 9150499 3.57 µM 0.422989247072217 0.325732373855299 no 1088 0.336151553217803 1565 4910996 YPR165W RHO1
SGTC_630 4356-0227 183 µM 0.422640941933602 0.325856525192764 no 1089 0.336278625247831 1591 779312
SGTC_899 1083-0020 478 µM 0.421719146314525 0.326185187030432 no 1090 0.336615013824713 1679 767123
SGTC_2639 lactacystin 53 µM 0.421265358695263 0.32634703246491 no 1091 0.336780661466063 1686 3870 A proteasome inhibitor.
SGTC_2719 novobiocin 32.65 µM 0.417600336245161 0.327655375947685 no 1092 0.338119675449254 1695 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3336 9143619 71.43 µM 0.415180515952815 0.328520368397504 no 1093 0.339004880513054 1652 45595730
SGTC_94 0334-0113 514.748 µM 0.414545090172174 0.328747661280549 no 1094 0.339237476078574 1541 6795178
SGTC_1090 efavirenz 20.7 µM 0.413945355927559 0.328962245366546 no 1095 0.339457063083863 1656 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_958 1222-0007 33 µM 0.413925418540921 0.32896937990471 no 1096 0.339464363905604 1691 7312461
SGTC_68 0986-0284 82.829 µM 0.412891789302472 0.329339346545056 no 1097 0.339842948487362 1527 423278 YIL048W NEO1
SGTC_2127 5253358 187.912 µM 0.412826937030318 0.329362564678177 no 1098 0.339866707144782 1552 20612
SGTC_1678 st019265 80.2 µM 0.412585525351751 0.329448999637798 no 1099 0.339955154006059 1757 5367020
SGTC_573 3702-0553 84.7 µM 0.411439194317701 0.329859555949293 no 1100 0.340375259579488 1603 1222756
SGTC_3081 9117243 49.47 µM 0.411074657448212 0.329990157141327 no 1101 0.340508896026363 1732 45595589
SGTC_2192 5915882 198.485 µM 0.410850553543249 0.330070456254138 no 1102 0.340591060756748 1598 2876149
SGTC_3015 9080845 49.47 µM 0.410490248390149 0.330199574316264 no 1103 0.340723177730252 1727 5296973
SGTC_2131 toluylene red 5.2905 µM 0.409541749266962 0.330539572775034 no 1104 0.341071067522584 1548 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1512 0259-0544 12.2 µM 0.407259175497062 0.331358355897887 no 1105 0.341908821729933 1673 18476
SGTC_1477 0139-0234 16 µM 0.406731912707665 0.33154760542892 no 1106 0.342102449546771 1651 620880
SGTC_3300 9124615 50.48 µM 0.405676229500339 0.331926649230322 no 1107 0.342490255068197 1686 24824903
SGTC_3063 1327-0034 4 µM 0.40426237127526 0.332434565549303 no 1108 0.343009896441186 1628 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2079 5212404 121 µM 0.40423201154956 0.332445475397133 no 1109 0.343021057942658 1730 758462
SGTC_3188 9110789 49.47 µM 0.404103550013915 0.332491639961126 no 1110 0.343068287277231 1694 849217
SGTC_2068 5226020 147 µM 0.403814073449915 0.332595676984022 no 1111 0.343174723338742 1584 1810509
SGTC_665 3914-0008 307 µM 0.403804629876968 0.332599071193513 no 1112 0.343178195804272 1568 1069549
SGTC_2515 chrysin 20.77 µM 0.402809579037955 0.332956789277822 no 1113 0.343544156870873 1696 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_382 3229-0966 23.2 µM 0.400218928065488 0.333888834004214 no 1114 0.344497637251024 1709 5722370
SGTC_3354 9151612 71.43 µM 0.40001583280745 0.333961945503398 no 1115 0.344572427657918 1719 27261949
SGTC_1239 0337-0584 35.4 µM 0.398965951518224 0.3343399887738 no 1116 0.344959146267145 1763 914301 YML130C ERO1
SGTC_480 am 92016 50 µM 0.398624881251285 0.334462838199608 no 1117 0.345084812706272 1579 2129 K+ channel blocker.
SGTC_2338 7999974 200 µM 0.398079287721487 0.334659391312701 no 1118 0.345285870724103 1797 315925
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.398027887476491 0.334677910874267 no 1119 0.345304814606985 1768 1273210
SGTC_1248 0469-0687 58.6 µM 0.396511156269529 0.3352245715631 no 1120 0.345863989686824 1705 4017482
SGTC_2404 5161160 200 µM 0.395596251581505 0.335554490675748 no 1121 0.346201451400511 1681 2831543
SGTC_1695 st026914 34.495 µM 0.39546543554986 0.3356016739468 no 1122 0.346249712755646 1607 3289191
SGTC_1862 st057513 3.81 µM 0.394965243650783 0.335782109144653 no 1123 0.346434269264681 1618 5393163
SGTC_2783 7738165 71.43 µM 0.391220246074229 0.337134249946614 no 1124 0.347817222156158 1529 17201110
SGTC_3187 9109394 49.47 µM 0.390991165129493 0.33721702874775 no 1125 0.34790188315557 1574 17098090
SGTC_1570 verbenone 133 µM 0.389581108071949 0.337726728767348 no 1126 0.348423162053503 1771 29025 A natural terpanoid with antifungal properties.
SGTC_2341 7987486 176.74 µM 0.389559447936404 0.337734560683837 no 1127 0.348431171746761 1790 1258686
SGTC_1237 0330-0133 46.1 µM 0.389147991350085 0.337883349346751 no 1128 0.348583336953159 1639 X1237 YHR072W ERG7
SGTC_1080 nisoldipine 24.4 µM 0.388853199991643 0.337989965752311 no 1129 0.348692371914669 1633 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_826 1683-5028 118 µM 0.388378308007684 0.338161746002123 no 1130 0.348868047272273 1649 722377
SGTC_1839 st053978 48 µM 0.388329883005759 0.338179264424382 no 1131 0.348885962808177 1662 3788398
SGTC_2403 6032726 181.2 µM 0.38769351155374 0.338409513247347 no 1132 0.349121429001588 1619 2881040
SGTC_867 0518-0118 155 µM 0.387624726786558 0.338434404237503 no 1133 0.349146883792759 1658 6848158
SGTC_935 2996-0153 430 µM 0.387456770571734 0.338495185144178 no 1134 0.349209041254394 1788 23738523
SGTC_495 decylubiquinone 155 µM 0.386159486549333 0.338964794981794 no 1135 0.349689278040889 1613 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2008 4012253 172 µM 0.383279819274125 0.340008112858754 no 1136 0.350756150384601 1628 603940
SGTC_613 3914-0030 117 µM 0.382941275476501 0.340130849692172 no 1137 0.350881653187015 1632 1145395
SGTC_1588 farnesol 29.9 µM 0.379909587875731 0.341230722011894 no 1138 0.352006264962911 1623 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_555 4296-0685 37 µM 0.377611521649567 0.342065342559895 no 1139 0.352859602159828 1693 2908540 YHR072W ERG7
SGTC_1353 1498-1206 8.11 µM 0.377007433933211 0.342284865812837 no 1140 0.353084040192621 1646 6756808
SGTC_176 1486-1328 72.834 µM 0.376328172290386 0.342531770658763 no 1141 0.353336468814269 1615 22310231
SGTC_2697 mebhydrolin 72.4 µM 0.376240062786079 0.342563802519896 no 1142 0.353369216981759 1803 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2939 9044578 71.43 µM 0.375012127668894 0.343010331218201 no 1143 0.353825723602076 1615 2653634
SGTC_2665 lovastatin 100 µM 0.374643085035682 0.343144573488741 no 1144 0.353962962854286 1665 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.372367468079191 0.343972784596702 no 1145 0.354809635954173 1651 75037 A free radical scavenger.
SGTC_3315 9136395 68.55 µM 0.369687468114744 0.344949131506512 no 1146 0.355807685158395 1809 16876844
SGTC_551 k048-0028 34.9 µM 0.369575918460333 0.344989792442723 no 1147 0.355849248455422 1759 6836383
SGTC_1660 st012960 28.1 µM 0.368090234309374 0.345531509314142 no 1148 0.356402976194964 1671 24207266
SGTC_749 1000-0129 128 µM 0.367053710908707 0.345909638678674 no 1149 0.356789477157647 1811 708470
SGTC_725 1497-0963 19 µM 0.366311062586663 0.346180655374715 no 1150 0.357066487840469 1821 3549977
SGTC_2978 9011784 42.97 µM 0.365488224031102 0.346481028128226 no 1151 0.357373497798463 1861 2994934
SGTC_246 cycloheximide 667 µM 0.364446158130852 0.346861567198628 no 1152 0.35776243635026 1663 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_326 k292-0812 17.5 µM 0.364265014820059 0.346927732444544 no 1153 0.357830060993341 1799 3579357
SGTC_225 nsc-122657 1.016 µM 0.363229659513534 0.347306000657706 no 1154 0.358216666690604 1726 275685
SGTC_2770 toltrazuril 17.5 µM 0.362322052678397 0.347637720989553 no 1155 0.358555690235855 1792 68591 Kills coccidiodes.
SGTC_305 1682-2595 20.8 µM 0.361997002271574 0.347756551736973 no 1156 0.35867713529465 1719 226033
SGTC_1325 1431-0015 227 µM 0.361653782270844 0.347882041093715 no 1157 0.358805384373091 1605 1103340
SGTC_91 0417-1751 58.384 µM 0.361369184950467 0.347986109249484 no 1158 0.358911740319928 1692 6795624
SGTC_2485 5633444 17.78 µM 0.36085215252678 0.348175200796832 no 1159 0.359104986822078 1628 5724239
SGTC_816 0325-0417 81.3 µM 0.360015523630653 0.348481256629355 no 1160 0.359417762348093 1660 68101
SGTC_1015 4130-4525 82 µM 0.359711886961526 0.34859235749897 no 1161 0.359531300888182 1630 1363237
SGTC_1351 1496-0003 46.5 µM 0.359375372604394 0.348715503510934 no 1162 0.359657147835663 1761 3891978
SGTC_3134 9127454 49.47 µM 0.359351296326759 0.348724314734562 no 1163 0.359666152272961 1717 24262820
SGTC_2268 7933382 153.85 µM 0.358871867484636 0.348899788855959 no 1164 0.359845473072404 1666 935025 YOR257W CDC31
SGTC_2397 5161689 200 µM 0.35834185090656 0.349093816038706 no 1165 0.360043751115224 1749 2259942
SGTC_3030 9087619 49.47 µM 0.357625791013003 0.349356012161592 no 1166 0.360311687358454 1656 25236973
SGTC_59 0330-0160 1.33 µM 0.356387252287587 0.349809691469652 no 1167 0.360775287352775 1749 4293482
SGTC_3335 9143315 29.6265 µM 0.355434781700936 0.350158729392127 no 1168 0.361131947847504 1671 4899691
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.355056003777428 0.350297569784867 no 1169 0.361273817954085 1717 688801
SGTC_2236 dapsone 200 µM 0.354713305454674 0.350423202502942 no 1170 0.361402190998934 1740 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1819 st053448 58.6 µM 0.354400623155274 0.350537845668146 no 1171 0.361519333810243 1709 2857616
SGTC_2272 7805186 180 µM 0.353659743144156 0.350809539391294 no 1172 0.361796947750759 1824 2956062 YPR165W RHO1
SGTC_675 1309-0189 238 µM 0.352422311165561 0.351263497559863 no 1173 0.362260786029213 1678 4246530
SGTC_1531 st059297 52.4 µM 0.351761336416578 0.35150606650886 no 1174 0.362508628355419 1741 7566702
SGTC_2098 5376439 882.5 nM 0.35143077978135 0.351627399095061 no 1175 0.362632597112601 1818 2844116
SGTC_2882 9058044 58.44 µM 0.350180176628662 0.352086576379547 no 1176 0.363101741415847 1607 18076804
SGTC_408 cantharidin 100 µM 0.349983912396457 0.352158657273654 no 1177 0.363175385559311 1737 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2963 9082507 9 µM 0.348308078414145 0.352774347760403 no 1178 0.363804413779729 1746 16459611
SGTC_960 1222-0186 7.7 µM 0.348188411361611 0.352818327432316 no 1179 0.363849345156742 1764 3126296
SGTC_106 0092-0003 11.579 µM 0.348014080987803 0.352882400321693 no 1180 0.363914804316033 1830 1072148
SGTC_1125 tnp00248 1.32998 µM 0.347102667796868 0.353217446424042 no 1181 0.364257094673925 1897 24207736
SGTC_864 0469-0573 172 µM 0.345829764797235 0.353685570813004 no 1182 0.36473532735057 1677 689425
SGTC_2141 5621638 7.665 µM 0.345086026944229 0.353959191264532 no 1183 0.365014848928698 1833 2856238
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.344559878958542 0.354152806181214 no 1184 0.365212636293199 1683 115019
SGTC_2217 6934799 96.0675 µM 0.344277364349775 0.354256783071345 no 1185 0.365318852811056 1776 675606
SGTC_440 fluspirilene 35.1 µM 0.340084593990444 0.355801166880545 no 1186 0.36689641164101 1796 3396 An atypical antipsychotic.
SGTC_2172 5754775 163.918 µM 0.339002968991734 0.356199963007039 no 1187 0.367303746766844 1661 2263357
SGTC_4 0960-0234 25.671 µM 0.338358243842431 0.356437748634027 no 1188 0.367546618456007 1705 6821112
SGTC_1786 berberine 21.6 µM 0.338351314373354 0.356440304643729 no 1189 0.367549229115024 1662 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_722 3534-0461 190 µM 0.337676699947024 0.356689174336566 no 1190 0.367803417590909 1689 658262
SGTC_2817 7995342 71.43 µM 0.336795506876087 0.357014344145579 no 1191 0.36813553019989 1628 18879975
SGTC_17 0960-0276 49.807 µM 0.336062573626476 0.357284883630887 no 1192 0.368411840312252 1737 6821114
SGTC_3085 9117376 49.47 µM 0.334878665570598 0.357722037938508 no 1193 0.36885830812222 1763 16480349
SGTC_2849 9019321 12.99 µM 0.333812816790156 0.358115758956341 no 1194 0.369260405633708 1748 16489627
SGTC_3103 9120822 49.47 µM 0.331445405417977 0.358990812335725 no 1195 0.37015403631844 1840 17141819
SGTC_49 0717-0965 32.132 µM 0.329809250683949 0.359596008309443 no 1196 0.370772048547763 1809 5889349 YGL099W LSG1
SGTC_142 0335-0849 62.6745 µM 0.328023375205717 0.360256986489777 no 1197 0.37144699436426 1750 3889043 YPR107C YTH1
SGTC_130 0136-0219 337.655 µM 0.327973432724916 0.360275476935747 no 1198 0.371465875096605 1873 234244
SGTC_2997 9067075 71.4286 µM 0.327321726457562 0.360516791240416 no 1199 0.371712280690283 1787 27209819
SGTC_2017 5132927 60.65 µM 0.32657175331183 0.360794560640854 no 1200 0.371995905354925 1663 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_3244 9134489 49.47 µM 0.326490816890573 0.360824541656021 no 1201 0.37202651802721 1707 16584271
SGTC_1142 3253-1408 9.78 µM 0.3232995831418 0.362007339974263 no 1202 0.373234184833532 1857 256655
SGTC_3 0833-0587 95.581 µM 0.322913670705753 0.362150464118943 no 1203 0.373380311380913 1770 5382644
SGTC_1737 st035557 69.7 µM 0.322903434567239 0.362154260679345 no 1204 0.373384187564083 1680 5716916
SGTC_1116 jasmonic acid 1.58368 µM 0.321827347370149 0.362553454546564 no 1205 0.373791747692641 1810 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_719 2810-4230 27.3 µM 0.321378766066422 0.36271990800149 no 1206 0.373961686283324 1769 721079
SGTC_624 k048-0052 28 µM 0.321263032726737 0.362762856968382 no 1207 0.37400553417578 1739 6835531
SGTC_2251 lansoprazole 556 µM 0.321033655353399 0.362847984656483 no 1208 0.374092443202453 1679 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_181 1447-1644 8.07 µM 0.319079420164312 0.363573524771834 no 1209 0.37483314448647 1872 534600
SGTC_2299 7976368 114.88 µM 0.319058905113042 0.363581143903895 no 1210 0.374840922630294 1854 2979718
SGTC_2492 derrusnin 100 µM 0.317261301280797 0.364248969314817 no 1211 0.37552266939278 1727 1715307 Part of coumarin class of compounds.
SGTC_92 0063-0024 660.874 µM 0.31718249496504 0.364278255994386 no 1212 0.375552565842746 1856 3594437
SGTC_1087 pterostilbene 9.05 µM 0.31486295800585 0.365140616496525 no 1213 0.376432853679634 1865 5281727 Similar to reservatol, lowers cholesterol.
SGTC_984 1492-0255 2.91 µM 0.313266446867496 0.365734566313939 no 1214 0.377039119805505 1778 1585198
SGTC_3217 9129673 49.47 µM 0.312414582632805 0.366051617090354 no 1215 0.377362734635034 1768 17248312
SGTC_1446 4239-0190 62 µM 0.311834550573059 0.36626754847581 no 1216 0.377583132404986 1737 1340085
SGTC_1029 k015-0030 64.7 µM 0.311698193263811 0.366318317032395 no 1217 0.377634950584581 1802 2208316
SGTC_2864 9034755 47.6 µM 0.311649690241888 0.366336376242872 no 1218 0.377653383118433 1897 4930451
SGTC_363 0455-0021 3.06 µM 0.310508056936822 0.366761527862922 no 1219 0.378087316760831 1743 4597466
SGTC_99 0109-0120 622.8 µM 0.309781315019869 0.367032256455345 no 1220 0.378363630788676 1852 759414
SGTC_3305 9127027 53.8275 µM 0.309595726046654 0.367101403353886 no 1221 0.378434203417996 1776 41905295
SGTC_1188 1403-0014 4.57 µM 0.309270580733446 0.367222556664471 no 1222 0.378557853941111 1764 9614867
SGTC_1835 st008666 49.2 µM 0.309216746365038 0.367242617316098 no 1223 0.378578327980783 1717 690455
SGTC_3173 9105693 49.47 µM 0.306862365058681 0.36812029955522 no 1224 0.379474068104865 1831 17096658
SGTC_2563 tomatine 8.54 µM 0.305732170312785 0.368541866208033 no 1225 0.379904288510594 2020 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_483 fpl-64176 144 µM 0.304156780230144 0.369129756286137 no 1226 0.380504225119981 1800 3423
SGTC_1485 3909-9022 254 µM 0.304007598628477 0.369185442445506 no 1227 0.380561051056135 1862 714516
SGTC_272 doxorubicin 8.13 µM 0.303630495149007 0.369326218988837 no 1228 0.38070470799467 1791 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2881 9058953 51.95 µM 0.303551187547202 0.369355827549725 no 1229 0.380734922186812 1747 17122249
SGTC_390 dec-rvkr-cmk 16.7 µM 0.302701192520757 0.369673211829693 no 1230 0.381058794451783 1807 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1943 st076331 65.2 µM 0.301255012553399 0.370213412859278 no 1231 0.381610021535342 1935 24208415
SGTC_1995 st072814 61.1 µM 0.300159074121435 0.370622956527648 no 1232 0.382027910327238 1740 5769371
SGTC_471 1-acyl-paf 4 µM 0.297086157757491 0.371772062209848 no 1233 0.383200366031114 1722 16759367
SGTC_1776 st049249 45.9 µM 0.296223877968034 0.372094714412017 no 1234 0.383529557363281 1725 1822314
SGTC_482 fipronil 114 µM 0.29599772120019 0.37217935377128 no 1235 0.383615910841466 1820 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1691 st019933 84.6 µM 0.295508453372041 0.372362483792092 no 1236 0.383802747837683 1927 6176082
SGTC_529 4076-0302 30.3 µM 0.294931939596236 0.372578306492203 no 1237 0.384022936163576 1758 5816522
SGTC_3314 9135860 59.4275 µM 0.294446337184108 0.37276012682212 no 1238 0.384208431700255 1926 25252478
SGTC_460 trequinsin 123 µM 0.29353540300274 0.373101277264765 no 1239 0.384556471473869 1826 5537 A vasodilator.
SGTC_1321 1326-2144 215 µM 0.293168752778962 0.373238618129277 no 1240 0.38469658346868 1904 3513030
SGTC_2720 fluspirilene 36.88 µM 0.290603294673784 0.374200044329841 no 1241 0.385677369997964 1858 3396 An atypical antipsychotic.
SGTC_1574 spiramycin 23.7 µM 0.289973759073026 0.374436087757989 no 1242 0.385918156376229 1758 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_606 k015-0008 38.6 µM 0.28834251153987 0.37504794036805 no 1243 0.386542284397995 1904 1970475
SGTC_2321 7390090 138.78 µM 0.287990369651437 0.375180064009386 no 1244 0.386677055217137 1734 649046
SGTC_740 k014-0057 261 µM 0.286757073328197 0.375642912185741 no 1245 0.387149166809473 1904 4012779
SGTC_1957 st077035 62.4 µM 0.285965393651882 0.375940118863101 no 1246 0.387452313533405 1847 705593
SGTC_163 TUB2.036 7.546 µM 0.285701081156803 0.376039361552821 no 1247 0.387553538278219 1877 15992207 YJR013W GPI14
SGTC_3078 9116413 49.47 µM 0.285114701330651 0.376259561681089 no 1248 0.387778133634941 1791 17177322
SGTC_215 1287-0124 461.5 µM 0.284921524750181 0.376332113090206 no 1249 0.387852132406929 1937 5560863
SGTC_571 k831-0106 44.2 µM 0.284696699624958 0.376416556258636 no 1250 0.387938259689195 1933 4783639
SGTC_61 0978-8327 98.565 µM 0.28426453010212 0.376578893533718 no 1251 0.388103833117963 1934 6150059 YHR072W ERG7
SGTC_424 splitomicin 100 mM 0.282802152027567 0.37712837322691 no 1252 0.38866425228422 1731 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_704 1310-0270 142 µM 0.282000867680084 0.377429556588927 no 1253 0.388971422490094 1755 5718033
SGTC_2856 9022925 19.48 µM 0.281679656246629 0.377550313125518 no 1254 0.389094577533084 1826 4944862
SGTC_1507 4075-3230 155 µM 0.280085070935854 0.378149960071592 no 1255 0.389706119086632 1932 659771
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.279771411346035 0.378267946983986 no 1256 0.389826443295704 1759 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1132 3456-3614 2.5 µM 0.279177602812433 0.378491346447995 no 1257 0.390054265469829 1980 3125502
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.27763564015986 0.37907164487734 no 1258 0.390646035197491 1882 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_558 k064-0027 21.3 µM 0.277213039119845 0.379230733168103 no 1259 0.390808264031477 1871 5088526
SGTC_260 nsc-65238 3.989 µM 0.273739792725505 0.380539010444188 no 1260 0.39214229757381 1881 3246252
SGTC_343 4130-2827 29.8 µM 0.273214176070514 0.380737115411007 no 1261 0.392344291732558 1774 1118244
SGTC_1772 st048439 82.2 µM 0.271954001292647 0.381212202683319 no 1262 0.392828694180762 1823 2927068 YDL195W SEC31
SGTC_2218 6965428 192.983 µM 0.271749282990204 0.3812893986357 no 1263 0.392907402173295 1904 675684
SGTC_627 1391-0720 175 µM 0.270827483279779 0.38163705283738 no 1264 0.393261860472636 1855 997839
SGTC_841 0251-0215 91.2 µM 0.269411649446636 0.382171216548272 no 1265 0.393806461255201 1882 3888614
SGTC_794 k038-0031 316 µM 0.267500255189361 0.382892700287138 no 1266 0.394542008857344 1792 6624242
SGTC_2291 7917025 104.35 µM 0.266201128745845 0.383383306788299 no 1267 0.395042156883356 1776 2964612
SGTC_2091 4-phenylthiadiazole 200 µM 0.266151804260141 0.383401937544609 no 1268 0.395061149629725 1824 270010
SGTC_2419 paclitaxel 166.5 µM 0.265966845370839 0.383471802285537 no 1269 0.395132371594417 1848 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_223 busulfan 5 mM 0.264705829738664 0.383948228090085 no 1270 0.395618043085817 1911 2478 A DNA alkylator.
SGTC_1314 1222-0010 41.1 µM 0.263467255364173 0.384416346138848 no 1271 0.396095229326111 1863 3526027
SGTC_282 k297-0036 65.7 µM 0.262293533808043 0.384860108745008 no 1272 0.396547573419752 1893 5061378
SGTC_3002 9075603 71.4286 µM 0.261511479107527 0.3851558730843 no 1273 0.396849049196122 1915 20105405
SGTC_3072 9116419 49.47 µM 0.257462041714648 0.386688390194667 no 1274 0.3984110570762 1813 17170162
SGTC_2062 5245942 200 µM 0.257368888426128 0.386723665132174 no 1275 0.398447008781039 1910 1376160
SGTC_441 propafenone 146 µM 0.256625814991643 0.387005082875514 no 1276 0.398733822373425 1846 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_514 4466-0038 2.65 nM 0.256579129274452 0.387022765736478 no 1277 0.398751844086782 1862 5722064
SGTC_412 gemfibrozil 100 µM 0.255153601254227 0.387562816913697 no 1278 0.399302233005794 1959 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1328 1441-0025 69.2 µM 0.254719235699621 0.387727416528663 no 1279 0.399469979125136 1758 4562601
SGTC_590 k048-0076 22.4 µM 0.25413938312248 0.38794717881855 no 1280 0.39969393929229 1969 6832814
SGTC_295 k015-0027 31 µM 0.253213930753742 0.388297996664822 no 1281 0.400051451023268 1891 3887424
SGTC_2594 a-mangostin 100 µM 0.252863199233431 0.388430974804895 no 1282 0.400186964112573 1962 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_690 glyoxal 20.3 µM 0.252473792331761 0.388578631847006 no 1283 0.400337434393105 1886 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_177 1327-0068 8.361 µM 0.251570661063831 0.388921147122462 no 1284 0.400686469233049 1903 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.251051869106973 0.389117939614567 no 1285 0.400887003618243 1829 6857784
SGTC_1845 st056753 3.01 µM 0.251016522032049 0.389131348797545 no 1286 0.400900667664548 1770 5375839
SGTC_2111 5486399 200 µM 0.250242008216112 0.389425199651321 no 1287 0.401200100287554 1838 689674
SGTC_1767 st044992 70.3 µM 0.250153631088214 0.389458733991924 no 1288 0.401234271214526 1813 9600693
SGTC_1817 st052116 64.4 µM 0.249744573447544 0.389613959963431 no 1289 0.401392442773499 1948 4361398
SGTC_2952 9073731 13.78 µM 0.244890370623422 0.391457332653391 no 1290 0.403270658924297 1821 16457353
SGTC_2552 juarezic acid 87.02 µM 0.243869111103953 0.391845465769517 no 1291 0.403666096391742 2007 1549512
SGTC_1139 k015-0024 46.9 µM 0.241497200169072 0.392747333307527 no 1292 0.40458489311093 2007 2766652
SGTC_1627 st003713 25.6 µM 0.241216701311683 0.392854025085141 no 1293 0.404693583625337 1840 16195070 YER133W GLC7
SGTC_3077 9117319 49.47 µM 0.240788536403115 0.39301689929147 no 1294 0.404859507442492 1944 17154678
SGTC_1555 citronellol 128 µM 0.240634089360225 0.393075655644156 no 1295 0.404919363448076 2012 8842 A terpine precursor.
SGTC_1821 st053465 65.6 µM 0.239883036524822 0.393361413687812 no 1296 0.405210465924781 1856 675086
SGTC_2606 farnesol 9.78 µM 0.239763311909618 0.393406971418103 no 1297 0.405256875143603 1972 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_855 0428-0020 25 µM 0.239667113285326 0.39344357807231 no 1298 0.405294165875902 1876 6812414
SGTC_47 0149-0135 24.25 µM 0.237436493556147 0.394292663753426 no 1299 0.40615909063645 1761 5239155
SGTC_290 2043-6722 48.1 µM 0.233893945335359 0.395642166601462 no 1300 0.407533656890392 1937 773758 YLR208W SEC13
SGTC_1157 4092-0394 27.6 µM 0.233474708927944 0.395801954224566 no 1301 0.40769640314318 1969 3659885
SGTC_750 4073-0104 132 µM 0.233430899735147 0.395818652656652 no 1302 0.407713410653625 1963 22330957
SGTC_2630 antimycin a 100 µM 0.232247140903915 0.396269929710357 no 1303 0.40817303269922 1875 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1645 Cervolide 78 µM 0.231774947681275 0.396449979832892 no 1304 0.408356408053321 1882 23173 A fragrance.
SGTC_2449 5812982 45.77 µM 0.229972224465428 0.397137571856418 no 1305 0.409056676481617 1937 776185
SGTC_3004 9076122 71.4286 µM 0.229837506981557 0.397188968470051 no 1306 0.409109019220061 1978 44782551
SGTC_2706 st078239 82.5 µM 0.228827129917944 0.397574498373401 no 1307 0.409501639776737 1958 15434492
SGTC_2248 tofa 1.1 µM 0.22744279747209 0.398102880964019 no 1308 0.410039722292888 1891 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3124 9127567 49.47 µM 0.226427965012176 0.398490348775513 no 1309 0.410434289863074 2012 17592030
SGTC_1435 4092-0789 56.7 µM 0.22410305431994 0.399378387354058 no 1310 0.411338557959643 2000 2248285
SGTC_2078 5212016 200 µM 0.223635254017756 0.399557134611499 no 1311 0.411520564797891 2054 1899708
SGTC_1375 2910-0797 186 µM 0.223554410714325 0.399588027104174 no 1312 0.411552020393795 1910 742508
SGTC_3102 9121669 49.47 µM 0.222362281253465 0.400043646077534 no 1313 0.412015935998065 1917 41905072
SGTC_678 1218-2179 85.9 µM 0.222132592502261 0.400131446287736 no 1314 0.41210533322293 1949 6820081 YOR116C RPO31
SGTC_1367 1812-0510 76.9 µM 0.221812937774694 0.400253645052941 no 1315 0.412229753721402 1960 1142582 YDR527W RBA50
SGTC_2671 danthron 100 µM 0.221431717959518 0.400399391909907 no 1316 0.412378148980644 1918 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1448 4255-0083 152 µM 0.221422525073541 0.400402906678832 no 1317 0.412381727597609 2006 5399660
SGTC_3028 9087778 49.47 µM 0.220898424584474 0.400603302359949 no 1318 0.412585762060856 1859 17217395
SGTC_21 0849-0113 22.993 µM 0.217694507769651 0.401828922780965 no 1319 0.413833571612645 1894 1560156
SGTC_2029 5175081 200 µM 0.217506332275788 0.401900937241937 no 1320 0.413906886339398 1953 1380876
SGTC_1447 4239-0816 81.9 µM 0.217209397437065 0.402014580504436 no 1321 0.414022580707823 1851 1341554
SGTC_1669 st015249 58.4 µM 0.214286950104116 0.403133503666442 no 1322 0.415161646998139 2075 722793
SGTC_2823 7987624 58.44 µM 0.214081201432155 0.403212309074637 no 1323 0.41524186752603 1932 2239440
SGTC_2704 st078022 71.1 µM 0.21278974668836 0.403707048909719 no 1324 0.41574548077987 2039 54697681
SGTC_615 k087-0205 167 µM 0.212789477219284 0.403707152155992 no 1325 0.415745585875994 1894 9642773
SGTC_724 3910-0327 137 µM 0.212239909271807 0.403917731428514 no 1326 0.415959936397678 1894 2885483
SGTC_2937 9044753 11.33 µM 0.211917852662007 0.404041147580505 no 1327 0.416085561246288 1932 6465530 YGL099W LSG1
SGTC_1167 k781-0610 148 µM 0.211317119699816 0.404271381540897 no 1328 0.416319912479242 1914 4525169
SGTC_540 1187-0821 17.3 µM 0.210895090798741 0.404433146096614 no 1329 0.416484567477218 1851 847520
SGTC_1937 st074714 47.2 µM 0.210624473511345 0.404536882865044 no 1330 0.416590156796196 1791 17250970
SGTC_2700 st077718 96.8 µM 0.210153767887119 0.404717336251804 no 1331 0.41677383081765 1879 904970
SGTC_197 4544-0043 41.561 µM 0.209348035175528 0.405026275259579 no 1332 0.417088277894464 2036 896523
SGTC_1924 st058459 75.1 µM 0.208939953979677 0.405182766865673 no 1333 0.417247556836723 1980 688683
SGTC_115 0527-0192 112.043 µM 0.208160293739157 0.405481794311458 no 1334 0.417551905237751 1924 4233931
SGTC_2355 9061122 103.12 µM 0.207576351293876 0.40570579316538 no 1335 0.41777988554621 2026 5302957
SGTC_3345 9148410 3.559 µM 0.206977532637842 0.405935530566295 no 1336 0.41801370246129 2033 4903596
SGTC_2092 5303694 80.6725 µM 0.20596814817899 0.406322855257592 no 1337 0.418407895953846 1911 1963699
SGTC_1724 st037281 8.293 µM 0.205876652029511 0.406357969031992 no 1338 0.418443631873589 1889 574124 YDL195W SEC31
SGTC_2243 6634756 200 µM 0.202967407635795 0.407474850413217 no 1339 0.419580253451924 2040 885676
SGTC_1742 st038235 28.8875 µM 0.202449468518474 0.407673770415614 no 1340 0.419782679333344 1932 564103 YBR002C RER2
SGTC_3309 9129340 25.759 µM 0.202405472865981 0.407690668509491 no 1341 0.419799875110652 1975 17158987
SGTC_3254 9136651 49.47 µM 0.196258945068693 0.410053135217524 no 1342 0.422203746765284 1949 16454030
SGTC_685 1278-0033 54.9 µM 0.195438825658537 0.410368603640916 no 1343 0.422524712059217 2028 3590572
SGTC_795 0685-0265 78 µM 0.195120307051403 0.41049114116005 no 1344 0.422649382689587 2058 302754
SGTC_2965 9082772 38.63 µM 0.193549085955414 0.411095734389605 no 1345 0.423264483851299 2086 16459634
SGTC_2892 9047358 58.44 µM 0.192938309441872 0.411330813371015 no 1346 0.423503641035233 1950 6466771
SGTC_1355 1499-0035 1.68 µM 0.192853437148409 0.411363482001682 no 1347 0.423536876075677 1934 1548538
SGTC_648 0375-0473 33.3 µM 0.192639732273359 0.41144574296498 no 1348 0.423620562922349 1971 1713139
SGTC_645 0845-0943 5.41 µM 0.192294442113418 0.411578662997439 no 1349 0.423755785856301 1971 1885106
SGTC_3259 9138485 49.47 µM 0.19011090804269 0.412419452540542 no 1350 0.42461111128976 2057 17646153
SGTC_2222 6885208 172.143 µM 0.189041425889494 0.412831413255305 no 1351 0.425030174471643 2009 609514
SGTC_536 3852-0578 10.6 µM 0.188094655290405 0.413196186061819 no 1352 0.425401225390966 2075 2869208
SGTC_496 calpeptin 138 µM 0.187810057870905 0.413305850730198 no 1353 0.425512775515567 1946 73364 A calpain inhibitor.
SGTC_891 0929-0073 133 µM 0.187507541093934 0.41342242772766 no 1354 0.425631355806008 2038 5603632
SGTC_2736 butenafine 14.65 µM 0.185437716972565 0.414220253463631 no 1355 0.426442863761975 2063 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_912 3474-0017 2.18 µM 0.185229495707756 0.414300533217355 no 1356 0.426524517571872 2038 3360550
SGTC_2575 plumbagin 510 nM 0.1844639650512 0.414595714483611 no 1357 0.426824746881588 1909 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2140 5586273 200 µM 0.183515858342216 0.414961362168066 no 1358 0.427196638455922 2077 854421
SGTC_224 benfluorex 43.875 µM 0.182845947788628 0.415219764915166 no 1359 0.42745944758624 2072 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1498 4478-3555 97.6 µM 0.182624246992925 0.415305289033408 no 1360 0.427546428969707 2099 3437919
SGTC_2832 7992762 51.95 µM 0.1825762194942 0.415323816827777 no 1361 0.427565272389702 1775 2985177
SGTC_3346 9158254 43.5805 µM 0.181865218403935 0.4155981250718 no 1362 0.427844250470267 1999 17639500
SGTC_2160 5660466 132.927 µM 0.181626154761636 0.415690366425215 no 1363 0.427938060851072 2099 2859134
SGTC_179 1273-0063 6.77 µM 0.179357334737456 0.416566008355611 no 1364 0.428828565022006 1965 3108139
SGTC_2803 7707263 71.43 µM 0.179235260723583 0.416613134109185 no 1365 0.428876488973799 1951 2199229
SGTC_2059 5238311 157 µM 0.178819602363396 0.416773604872299 no 1366 0.429039676453571 1956 703021
SGTC_1708 st033234 31.827 µM 0.178311806564362 0.416969665409818 no 1367 0.429239053551767 2054 674664
SGTC_1904 st060225 78 µM 0.175990096946063 0.417866342494142 no 1368 0.4301508612559 2065 66595
SGTC_1433 4060-0023 7.6 µM 0.173244590370835 0.418927246872281 no 1369 0.431229587732042 2059 3840627
SGTC_1861 st057647 17.4 µM 0.172381243690208 0.419260979074281 no 1370 0.431568908409214 2092 688668
SGTC_2617 dihydrotanshinone i 20.83 µM 0.17160994834797 0.419559177382762 no 1371 0.43187209291928 1984 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1172 0370-0043 85 µM 0.171387588754564 0.419645154665719 no 1372 0.431959506566096 2044 376585
SGTC_1587 estradiol valerate 56.1 µM 0.170735879159404 0.419897165967048 no 1373 0.432215724771867 2105 13791 A steroid.
SGTC_1112 tnp00069 1.16933 µM 0.170338000529995 0.420051038859797 no 1374 0.432372163910529 2088 145826
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.169100166268024 0.420529828572539 no 1375 0.432858927075132 2012 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_31 0508-1974 57.237 µM 0.168172997116907 0.420888531240933 no 1376 0.433223591776178 2080 6810525
SGTC_3293 9120939 62.045 µM 0.168009402732913 0.420951829368334 no 1377 0.433287940959056 2043 934087
SGTC_5 0352-0601 109.883 µM 0.166057857668009 0.421707080574403 no 1378 0.434055709166618 2028 762456
SGTC_647 0140-0236 81 µM 0.164607195944062 0.4222686759117 no 1379 0.434626583470408 2050 990837
SGTC_1143 3454-2408 5.08 µM 0.161266001939867 0.423562753368851 no 1380 0.435941949630684 2093 X1143
SGTC_1806 st050005 60.3 µM 0.160351750007492 0.423916996504242 no 1381 0.436301997810824 1972 5194765
SGTC_1164 k060-0068 93.7 µM 0.159116044629015 0.424395890149564 no 1382 0.436788723738829 2143 5963676
SGTC_2314 7727897 200 µM 0.157795242299646 0.42490788626482 no 1383 0.437309073892116 1997 900724
SGTC_2705 st078069 42.8 µM 0.156755797059 0.425310906189293 no 1384 0.43771865545315 2023 1530061
SGTC_149 3970-0822 46.1 µM 0.156584666617683 0.425377265402128 no 1385 0.437786093865062 2077 3114250 YBL034C STU1
SGTC_250 brefeldin a 552.239 µM 0.155546005573369 0.42578007204926 no 1386 0.438195444027906 2032 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_992 3909-8734 162 µM 0.155446006319511 0.425818857192234 no 1387 0.438234858564092 2001 4288319
SGTC_1335 1486-0900 202 µM 0.153829634319921 0.42644587335902 no 1388 0.438872033564118 2138 X1335
SGTC_673 1082-0474 110 µM 0.152816197642706 0.426839096361027 no 1389 0.439271611948171 2048 3098046
SGTC_2587 piperic acid 92.2 µM 0.151517724158589 0.427343022560994 no 1390 0.439783665194657 2016 5370536
SGTC_2867 9039098 71.43 µM 0.150361400812439 0.42779188137611 no 1391 0.440239746346347 2075 6463460
SGTC_2781 5567276 71.43 µM 0.148427688588124 0.428542713698194 no 1392 0.441002624874937 2089 2853274
SGTC_2037 5169046 200 µM 0.148260101103713 0.428607797701432 no 1393 0.441068751007655 2066 5718022
SGTC_2148 5546263 113.568 µM 0.147923864977806 0.428738383670967 no 1394 0.441201426934337 2044 792097
SGTC_1581 himbacine 57.9 µM 0.147139437028286 0.429043066799641 no 1395 0.441510981188552 1993 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1781 st038725 66.3 µM 0.146824349558348 0.429165463230815 no 1396 0.44163533239931 1952 4270275 YIL048W NEO1
SGTC_1037 k284-1091 78.7 µM 0.146524296389256 0.429282025885644 no 1397 0.441753755578547 2138 3334711
SGTC_1709 st033179 39.1045 µM 0.146221907954695 0.429399501967517 no 1398 0.44187310569382 2142 573381
SGTC_2128 5255449 168.493 µM 0.146146381255533 0.429428844610619 no 1399 0.441902916256692 2085 736008
SGTC_743 1275-0778 158 µM 0.145536295008805 0.429665881603615 no 1400 0.442143730759425 2139 2849257 YMR203W TOM40
SGTC_104 0074-0074 590.992 µM 0.145391641404982 0.429722087633962 no 1401 0.442200831867829 2162 3943124
SGTC_2436 5633522 8.09 µM 0.145391602317761 0.429722102821731 no 1402 0.442200847297429 2162 5724242
SGTC_65 0798-0905 34.986 µM 0.145003646150431 0.429872852561931 no 1403 0.442353996503314 2145 3602145
SGTC_2842 9000675 19.48 µM 0.142989754457148 0.43065556264046 no 1404 0.443149136401213 1935 2989072
SGTC_2189 6047310 154.431 µM 0.142141121465419 0.430985470302489 no 1405 0.443484268840613 2111 711535
SGTC_950 1165-0508 94.1 µM 0.141015488162747 0.43142313662573 no 1406 0.443928853412057 2023 6148369
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.140646810769981 0.431566503310869 no 1407 0.444074483060173 2080 65057 A dermal irritant. YDR527W RBA50
SGTC_2270 7924575 90.91 µM 0.140122442023246 0.431770428840988 no 1408 0.444281624674362 2184 1262135
SGTC_723 4182-0001 115 µM 0.139761917445972 0.431910646386694 no 1409 0.444424051688152 2007 744821 YLR208W SEC13
SGTC_508 roscovitine 141 µM 0.138750045018203 0.432304236112697 no 1410 0.444823835165209 2108 160355 A CDKinase inhibitor.
SGTC_2816 7982706 58.44 µM 0.138656490831227 0.432340629441899 no 1411 0.444860800588736 2035 2981853
SGTC_967 1306-0166 352 µM 0.13863779496761 0.432347902351653 no 1412 0.444868187814453 2171 4437607
SGTC_2273 7815444 169.05 µM 0.13835405261452 0.432458284260365 no 1413 0.444980304203768 2190 2824616
SGTC_3294 9122953 26.2835 µM 0.137513819517756 0.432785183983793 no 1414 0.445312335059008 2151 16459826
SGTC_662 k832-1615 104 µM 0.1374313286777 0.432817280219694 no 1415 0.445344934637864 2086 5878478
SGTC_3127 9126946 49.47 µM 0.13641689581877 0.433212020539537 no 1416 0.44574585880262 1999 27243249
SGTC_1442 4112-3290 3 µM 0.136260415935514 0.433272916583084 no 1417 0.445807707733406 2162 704353
SGTC_1849 st056239 19.2 µM 0.135780743345518 0.433459596852331 no 1418 0.445997307323019 1954 5393181
SGTC_298 1391-0729 10 µM 0.132025658166177 0.434921520831086 no 1419 0.447481998554074 2073 3237558
SGTC_1825 st052143 62.6 µM 0.130724810982993 0.4354281732667 no 1420 0.44799650222076 2169 674173
SGTC_1366 1683-0113 21.9 µM 0.130511572070487 0.435511235443906 no 1421 0.448080849630583 2103 708623
SGTC_252 miconazole 1.30953 nM 0.130140907680366 0.435655625763445 no 1422 0.448227472832115 2162 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1959 st077091 55.8 µM 0.130085670208685 0.435677143958311 no 1423 0.448249323648642 2132 821356 YKL052C ASK1
SGTC_341 1486-1430 230 µM 0.129740843437249 0.435811478262598 no 1424 0.448385733629193 2126 2054753 YPL210C SRP72
SGTC_2582 agaric acid 100 µM 0.129681736738606 0.435834505226971 no 1425 0.448409116254059 2115 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2870 9038528 12.99 µM 0.129321228926856 0.435974957644761 no 1426 0.448551737112569 2091 6463316
SGTC_1356 1502-0781 85.8 µM 0.129191804922649 0.436025382695689 no 1427 0.448602940296246 2057 567702
SGTC_2330 7979373 200 µM 0.128524937969429 0.436285218043447 no 1428 0.448866782118173 2008 1863007
SGTC_46 0329-0187a 2.197 µM 0.127648907688928 0.436626592716605 no 1429 0.449213412476561 2096 46494817
SGTC_1488 4013-0813 75.9 µM 0.127618130099348 0.436638587099704 no 1430 0.44922559135436 2062 2910057
SGTC_2247 cerulenin 830 nM 0.127610917988718 0.436641397751166 no 1431 0.449228445236947 2148 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1938 st074717 56.4 µM 0.1267546327603 0.436975125717387 no 1432 0.449567301914861 2174 17250979
SGTC_1281 0884-0031 11.8 µM 0.126752528608444 0.436975945843305 no 1433 0.449568134633634 2108 1548255
SGTC_156 3474-0145 5.642 µM 0.125719949486551 0.437378442230308 no 1434 0.449976804877988 2202 2265471
SGTC_1991 st073000 8.92 µM 0.124729309110918 0.437764651940668 no 1435 0.450368926636787 2152 4301969 YIL048W NEO1
SGTC_3118 9124250 49.47 µM 0.12421877112503 0.437963712762927 no 1436 0.450571030068956 2080 1504786
SGTC_1428 4049-0204 61.7 µM 0.124130637220122 0.437998078118752 no 1437 0.450605920377292 2185 X1428
SGTC_105 0111-0055 734.78 µM 0.123702354517888 0.438165081654892 no 1438 0.450775473673121 2118 5179370
SGTC_2239 6685329 187.64 µM 0.123307151552902 0.438319195927652 no 1439 0.450931938966324 2043 805680
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.123038150176632 0.438424101685633 no 1440 0.451038443995751 2146 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_969 1313-0238 134 µM 0.122705665671983 0.438553770713942 no 1441 0.451170088608729 2087 5212874
SGTC_1621 st003705 32.4 µM 0.122246625554509 0.438732807295694 no 1442 0.451351850740357 2187 24207032
SGTC_619 1652-1634 108 µM 0.120945067101611 0.43924051415025 no 1443 0.451867272882151 2088 5400454
SGTC_3054 9094397 49.47 µM 0.118725934864076 0.440106374697725 no 1444 0.45274624440976 2135 2598354
SGTC_3348 9149464 3.537 µM 0.117856100509553 0.440445844875491 no 1445 0.453090838732731 2218 1951442
SGTC_2666 tannic acid 100 µM 0.116808319810191 0.440854820262504 no 1446 0.453505975316899 2189 16134267 A thiamine antagonist.
SGTC_2601 securinine 100 µM 0.116494986228739 0.4409771345821 no 1447 0.45363012972743 2102 442872 A GABA receptor antagonist.
SGTC_1185 1319-0113 81.3 µM 0.115957530729505 0.441186951257047 no 1448 0.453843100118672 2122 4672763
SGTC_2852 9023854 51.95 µM 0.115857758060907 0.441225903220437 no 1449 0.453882637178654 2150 19798528
SGTC_1382 3002-2117 298 µM 0.115569202035142 0.441338560755209 no 1450 0.453996986264089 2195 1497314
SGTC_849 0386-0493 241 µM 0.114055036917791 0.441929796023115 no 1451 0.454597082448383 2095 726119
SGTC_417 st075190 100 µM 0.112733467408418 0.442445934384684 no 1452 0.455120933608426 2219 222757
SGTC_1333 1482-0047 286 µM 0.112287285506284 0.442620212626332 no 1453 0.455297811371056 2234 3811116
SGTC_991 3996-0057 64.7 µM 0.112252659831625 0.442633737847814 no 1454 0.455311538233048 2134 715343
SGTC_1629 st005085 44.9 µM 0.111995917205548 0.442734026812619 no 1455 0.455413321901574 2109 24207091
SGTC_2159 5658611 73.75 µM 0.111135248832674 0.44307024836189 no 1456 0.455754548668468 2215 793844
SGTC_2846 9008642 19.48 µM 0.110824001723964 0.443191847675437 no 1457 0.455877955982748 2070 2992898
SGTC_3179 9107801 49.47 µM 0.109897451791636 0.443553867679154 no 1458 0.456245351739834 2174 4818259
SGTC_1320 1313-0481 95.3 µM 0.108336053772559 0.444164040886441 no 1459 0.456864562065873 2193 6813365 YLR208W SEC13
SGTC_805 3852-0218 479 µM 0.108043079233213 0.444278546162422 no 1460 0.456980759955294 2045 6615355
SGTC_2987 9018338 71.43 µM 0.107008772119114 0.44468282873311 no 1461 0.457391010286348 2232 5055682
SGTC_3052 9092717 49.47 µM 0.106764506103967 0.444778314103351 no 1462 0.45748790325419 2124 25237534
SGTC_1422 4031-0024 15.5 µM 0.106260865375164 0.4449752010535 no 1463 0.457687690325195 2213 782427
SGTC_3338 9144300 39.5675 µM 0.103700986737173 0.445976136542776 no 1464 0.458703321787783 2157 4901274
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.103685470116901 0.445982204736854 no 1465 0.458709478833364 2206 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2905 7799065 20.05 µM 0.103542524752552 0.446038107983211 no 1466 0.458766200486394 2220 1296806
SGTC_2320 7373003 200 µM 0.102262167291633 0.44653887943507 no 1467 0.459274291980096 2112 5415828
SGTC_2893 9048488 25.97 µM 0.101515349899403 0.446831012936256 no 1468 0.459570686523782 2117 6467338
SGTC_1784 st039334 36.3 µM 0.100696204765934 0.44715147214712 no 1469 0.459895812109835 2245 3496984
SGTC_2055 5235184 200 µM 0.0993811739380731 0.447665999752256 no 1470 0.460417814889739 2172 2836034
SGTC_1169 aniline yellow 25.8 µM 0.0992788043436638 0.447706057258764 no 1471 0.460458453474624 2185 6051 A DNA damaging agent.
SGTC_650 1328-0195 38 µM 0.0989125845510156 0.447849364444407 no 1472 0.460603838440656 2237 2780821
SGTC_186 3455-3465 67.277 µM 0.0984198419476461 0.448042192602656 no 1473 0.46079945978635 2231 755278
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.0970559186954318 0.448576009426074 no 1474 0.461340993656649 2172 5379071
SGTC_1493 4348-0038 111 µM 0.0962881854421614 0.448876528444043 no 1475 0.461645847069047 2234 800424
SGTC_1389 3405-0187 19 µM 0.0943109738267148 0.449650616394568 no 1476 0.462431066459136 2118 799890
SGTC_2002 4023503 131 µM 0.09429323871772 0.449657560647448 no 1477 0.462438110353945 2274 4736863 YCR052W RSC6
SGTC_993 3909-8757 62.7 µM 0.0940643984976928 0.449747165333259 no 1478 0.462529000416336 2151 4288324 YLR208W SEC13
SGTC_145 3737-0113 38.366 µM 0.0937118540098623 0.449885212679928 no 1479 0.462669026790596 2257 6849351
SGTC_2971 9092186 9.93 µM 0.0930087751957702 0.450160538337275 no 1480 0.46294829492313 1987 25236400
SGTC_1362 1611-0397 101 µM 0.0927091594999247 0.450277875138614 no 1481 0.463067310062758 2203 27816
SGTC_1966 st070145 16.1 µM 0.0899668325973337 0.451352037790668 no 1482 0.46415678583301 2237 3748532
SGTC_1667 st014849 34.6 µM 0.0891520403784355 0.451671258899813 no 1483 0.46448053988464 2242 5348460
SGTC_1009 4106-0057 9.87 µM 0.0869730781190718 0.452525090563546 no 1484 0.465346455773625 2263 2928005
SGTC_2178 5812956 200 µM 0.08681511699772 0.452586996596947 no 1485 0.465409235683071 2264 5403383
SGTC_2388 9080168 200 µM 0.083676061612742 0.453817450747482 no 1486 0.46665699522396 2246 15943073
SGTC_1199 1638-0010 4.46 µM 0.082811124856451 0.454156569071466 no 1487 0.467000861578649 2176 3111136
SGTC_1982 st072467 71.9 µM 0.0816969237038541 0.454593466451895 no 1488 0.467443862356189 2111 3163533
SGTC_889 0919-1524 82.7 µM 0.0815714565448901 0.454642667727958 no 1489 0.467493750004257 2110 3905452
SGTC_1965 Pectolinarigenin 58.4 µM 0.0814400964832217 0.454694180620011 no 1490 0.467545981307046 2222 5320438 An anti-inflammatory.
SGTC_2152 5568786 200 µM 0.0814136350454777 0.45470455757389 no 1491 0.467556502954459 2253 5399883
SGTC_3255 9139072 49.47 µM 0.0809083421024119 0.454902716054221 no 1492 0.467757422840071 2178 17646060
SGTC_2421 5690543 90.72 µM 0.0808947617748425 0.454908041945811 no 1493 0.467762822906092 2174 3397993
SGTC_3341 9147222 25.867 µM 0.0797760082793877 0.455346819040747 no 1494 0.468207703056938 2179 1939759
SGTC_2750 bromebric acid 70.15 µM 0.0794343644084148 0.455480823252562 no 1495 0.468343568071206 2196 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1118 chelidonine 707.474 nM 0.0791106904506792 0.455607783733138 no 1496 0.468472290207823 2269 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_3034 9090421 49.47 µM 0.0786796800332848 0.455776853767053 no 1497 0.46864370417542 2264 17173761
SGTC_1899 st063254 59.6 µM 0.0785731929937627 0.455818626074441 no 1498 0.468686055245622 2239 3093813
SGTC_416 estradiol valerate 100 µM 0.0773455779339009 0.456300225123508 no 1499 0.469174316764617 2163 13791 A steroid.
SGTC_1509 1326-1131 80 µM 0.0771876865515976 0.456362171315715 no 1500 0.46923711856505 2266 768313
SGTC_1124 fisetin 1.16336 µM 0.0768782404866396 0.456483580670912 no 1501 0.469360203941979 2118 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2032 5185112 25.99 µM 0.076705177250764 0.456551482792269 no 1502 0.469429042913788 2247 5718189
SGTC_2365 9042475 200 µM 0.0764422955630772 0.456654628004705 no 1503 0.46953361051561 2176 6464479
SGTC_3312 9133330 71.43 µM 0.0755499862291167 0.457004759471511 no 1504 0.469888563941613 2246 17617324
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.0751104237065872 0.457177250814978 no 1505 0.470063427167892 2194 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2444 5485484 36.41 µM 0.0746231684461721 0.457368466976357 no 1506 0.47025726988096 2234 6790631
SGTC_631 k072-0230 41.5 µM 0.0745708846126157 0.457388985585065 no 1507 0.470278070158335 2223 5773147
SGTC_1241 0364-0022 50.8 µM 0.074349006989855 0.457476061949856 no 1508 0.470366341482837 2220 4563895
SGTC_2110 5483698 200 µM 0.0738268039929728 0.457681009722092 no 1509 0.470574099358393 2192 2848765 YHR062C RPP1
SGTC_2208 7283366 200 µM 0.0735796058647115 0.457778030913286 no 1510 0.470672449652658 2256 898663
SGTC_1881 5652484 16 µM 0.0696008861382727 0.459339955005647 no 1511 0.47225566580833 2279 2255129
SGTC_324 1315-0088 19.6 µM 0.0688758254077109 0.45962466008588 no 1512 0.47254423067092 2276 6787421
SGTC_2505 galangin 7.89 µM 0.0684420375567089 0.459795002767916 no 1513 0.472716879566435 2238 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2280 7785178 200 µM 0.0684158369610583 0.459805291627742 no 1514 0.47272730764836 2240 2954328
SGTC_547 1120-0019 610 nM 0.0682230251492827 0.459881008814128 no 1515 0.472804049125834 2270 3676939
SGTC_2686 alizarin 95.37 µM 0.0674887767435361 0.460169361414049 no 1516 0.473096298258217 2211 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1614 st002383 48.6 µM 0.0660601253318791 0.460730478507076 no 1517 0.473664978424397 2305 1947235
SGTC_1504 k297-0033 30 µM 0.0650250127849464 0.46113707820541 no 1518 0.47407704253642 2275 4388117
SGTC_1165 k072-0275 30.3 µM 0.0648813825158723 0.461193500433993 no 1519 0.474134221978456 2281 6153523 YGL055W OLE1
SGTC_873 0591-4978 488 µM 0.0628550329161194 0.461989593366509 no 1520 0.47494097126695 2291 3305145
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0625586581381401 0.462106043109955 no 1521 0.47505897546307 2285 688667
SGTC_2589 lobaric acid 100 µM 0.0623461214506415 0.46218955371032 no 1522 0.47514360014181 2234 73157 A novel microtubule depolymerizer.
SGTC_2496 diffractaic acid 79.83 µM 0.0622637121122828 0.462221934701845 no 1523 0.475176412961239 2299 94870 An apoptosis inducer which activates caspases.
SGTC_587 k089-0003 57 µM 0.0620951817706143 0.462288155883826 no 1524 0.475243516992906 2302 9659696
SGTC_591 4299-0174 154 µM 0.0620152332917608 0.462319570668504 no 1525 0.475275350469369 2244 5509088
SGTC_459 nigericin 15.3 µM 0.0612134828408224 0.462634621745109 no 1526 0.475594596057893 2235 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_632 0781-2353 4.65 µM 0.0605463807215448 0.462896780091597 no 1527 0.475860238553105 2244 6811515 YHR007C ERG11
SGTC_1559 coumarin 343 70.1 µM 0.0604577564135095 0.462931608961167 no 1528 0.475895529885528 2280 108770 A hepatotoxic, DNA x-linker.
SGTC_672 1441-0018 53.7 µM 0.0604401091422786 0.46293854427642 no 1529 0.475902557277117 2274 251141
SGTC_933 2914-0560 114 µM 0.0603721125409234 0.46296526680586 no 1530 0.475929634550116 2304 463887
SGTC_297 0986-0032 24 µM 0.0591735105538471 0.46343634233824 no 1531 0.476406954088549 2274 2847425
SGTC_1956 st077085 54 µM 0.0587246798276166 0.463612755387188 no 1532 0.476585700798487 2245 24208685
SGTC_296 1222-0039 74.9 µM 0.0582468364841472 0.463800579717003 no 1533 0.476776006952224 2241 5984176
SGTC_2369 9071472 200 µM 0.0580023558721832 0.463896680039203 no 1534 0.476873375986715 2265 17296037
SGTC_2483 5729050 27.16 µM 0.0569688764759807 0.464302942834063 no 1535 0.477284993917812 2287 2865180
SGTC_1021 4476-0760 85.3 µM 0.0567539537099451 0.464387434087608 no 1536 0.477370597196981 2270 746768
SGTC_1292 0kpi-0043 232 µM 0.0552667048344436 0.464972150812429 no 1537 0.477962993650891 2242 3333905
SGTC_1074 carmofur 3.8 µM 0.0551915338092508 0.465001706563938 no 1538 0.477992936849049 2316 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1759 st043059 70 µM 0.0550420064970573 0.465060498301983 no 1539 0.478052499076353 2273 669426
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.0535560899422606 0.465644778073314 no 1540 0.478644420710405 2287 165506
SGTC_799 1310-0557 151 µM 0.0522663506020578 0.466151978757849 no 1541 0.479158232491701 2231 5354492
SGTC_237 nikkomycin 200 µM 0.0519790991304266 0.466264950294942 no 1542 0.47927267368713 2305 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3245 9134821 49.47 µM 0.0509207178222192 0.46668121859432 no 1543 0.479694348244701 2315 17014901
SGTC_1155 4088-0394 48.2 µM 0.0507735675437626 0.466739096658803 no 1544 0.479752976873125 2289 2326248
SGTC_684 1140-0066 328 µM 0.0504190762146108 0.466878530283124 no 1545 0.479894217548666 2245 6813534
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.0503907834476746 0.466889658976219 no 1546 0.479905490400302 2269 6708739 YPR165W RHO1
SGTC_1732 st034308 51.822 µM 0.0500980778954688 0.467004793462702 no 1547 0.480022115716952 2291 830119
SGTC_1693 xanthone 101.9 µM 0.049703291316514 0.467160085458932 no 1548 0.480179416806027 2246 7020 An insecticide.
SGTC_1108 betulinic acid 729.144 nM 0.0464487752280802 0.468440459876306 no 1549 0.481476280713933 2312 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1948 st076329 66.6 µM 0.0460820339082283 0.468584762011737 no 1550 0.481622432829441 2332 24208413
SGTC_1705 st027868 56.3335 µM 0.0452682292838834 0.468904985381417 no 1551 0.481946755412885 2318 292948
SGTC_1459 k035-0031 35.7 µM 0.0447343573567245 0.469115069184883 no 1552 0.482159523944792 2325 3877128 YMR208W ERG12
SGTC_339 3091-4833 71.4 µM 0.043723816246609 0.469512750451371 no 1553 0.482562277374292 2284 3240077
SGTC_1479 0549-0158 134 µM 0.0424796649905015 0.470002406750878 no 1554 0.48305816105118 2322 5440202
SGTC_791 1348-1292 225 µM 0.0423066609577591 0.470070498958186 no 1555 0.483127117682837 2303 5437054
SGTC_653 0203-0016 55.2 µM 0.0417102317966115 0.470305252657799 no 1556 0.483364848633352 2298 295302
SGTC_3031 9088762 49.47 µM 0.0410417735387183 0.470568369172791 no 1557 0.483631296716468 2332 205253
SGTC_2969 9091408 28.7 µM 0.0401295784915175 0.470927445333914 no 1558 0.483994910281212 2157 4286311
SGTC_1925 st057770 10.1 µM 0.0396691228646967 0.471108707932381 no 1559 0.484178459338006 2298 5989122
SGTC_1350 1495-0454 146 µM 0.0394690390735919 0.471187474627331 no 1560 0.484258218757174 2321 1069057
SGTC_1921 5740136 50 µM 0.0390199025707938 0.471364289641021 no 1561 0.484437260369664 2327 1774243
SGTC_1947 st076332 61.6 µM 0.0388610832899641 0.47142681459876 no 1562 0.48450057207573 2339 24208416
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.0387744928509437 0.471460904355642 no 1563 0.484535090646476 2339 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1491 4138-0063 26.5 µM 0.0387632084517559 0.471465346921856 no 1564 0.484539589088517 2351 23883227
SGTC_2414 st077232 92.9 µM 0.0381319608247039 0.471713869059632 no 1565 0.484791234390273 2266 729801
SGTC_2145 5634607 200 µM 0.0380600341369532 0.47174218729138 no 1566 0.484819908172347 2326 308662
SGTC_521 r062-0005 13.8 µM 0.0372943279344378 0.472043662046774 no 1567 0.485125164000529 2331 2832033
SGTC_153 4077-0274 519.67 µM 0.0372535542462658 0.472059715962415 no 1568 0.485141419052793 2351 3121976
SGTC_1505 k297-0037 20.6 µM 0.0357658754008378 0.472645493921916 no 1569 0.485734521566731 2313 4089396
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.0353036622822706 0.472827503815095 no 1570 0.485918801536925 2252 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_839 0122-0028 230 µM 0.0351950978523604 0.472870255049227 no 1571 0.48596208557917 2322 759448
SGTC_2003 4023581 200 µM 0.0351437398830504 0.47289047924602 no 1572 0.485982561777262 2299 16641307
SGTC_473 2-arachidonoylglycerol 10 µM 0.0328383804027572 0.47379837534723 no 1573 0.486901735785412 2313 5282280 An endocannabinoid.
SGTC_1919 st067113 52.3 µM 0.0316668111591211 0.474259814914741 no 1574 0.487368881231878 2306 1268243
SGTC_10 0279-0212 42.575 µM 0.0295506444527583 0.475093385022652 no 1575 0.488212714062396 2354 39851 YBR002C RER2
SGTC_2287 7945887 168.79 µM 0.028726996746802 0.475417854219396 no 1576 0.488541162479584 2334 1245853
SGTC_2117 5521686 200 µM 0.0285067837851711 0.475504608064007 no 1577 0.488628978775589 2331 803312
SGTC_2157 5649910 96.377 µM 0.0279595666027717 0.475720191649206 no 1578 0.488847199852815 2339 2858091
SGTC_1857 st056007 79.3 µM 0.0268675635296625 0.476150422161998 no 1579 0.489282682363305 2357 619834
SGTC_2836 9010338 19.48 µM 0.0256281912941424 0.476638747261223 no 1580 0.48977695002514 2353 2994051
SGTC_2401 5128683 200 µM 0.0247171215155162 0.476997740313876 no 1581 0.490140299129054 2345 708373
SGTC_148 3253-0744 288.01 µM 0.0229989915841718 0.477674793589001 no 1582 0.490825538668353 2373 6893655
SGTC_2386 9075165 157.42 µM 0.022972757257447 0.47768513209905 no 1583 0.490836001885993 2359 16452277
SGTC_367 0335-0881 7.1 µM 0.0210101116712361 0.478458620051016 no 1584 0.491618794754889 2354 23828853
SGTC_1260 0700-1617 7.75 µM 0.0200800576670207 0.478825187268452 no 1585 0.49198975430749 2334 2853078
SGTC_117 lucigenin 22.078 µM 0.0188780848131174 0.479298953821791 no 1586 0.492469181105858 2333 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1474 0330-0125 5.35 µM 0.0169195120528025 0.48007100222346 no 1587 0.493250413313816 2381 X1474
SGTC_1980 st071811 45.7 µM 0.0165161902896347 0.480229996720845 no 1588 0.493411292933244 2346 4974850
SGTC_1731 st035964 63 µM 0.0155383804455069 0.480615474631543 no 1589 0.493801332508017 2294 6739575
SGTC_344 k064-0035 6.43 µM 0.014867792219201 0.480879848341519 no 1590 0.494068827583851 2370 5088750
SGTC_34 0469-0683 81.75 µM 0.0145612784791283 0.481000691586472 no 1591 0.494191095636505 2359 3690923
SGTC_866 0495-0101 262 µM 0.0142578080557726 0.481120336721841 no 1592 0.494312150250532 2364 635694
SGTC_3208 9114115 49.47 µM 0.0138260964110446 0.48129054469841 no 1593 0.494484361298403 2349 650895
SGTC_53 0973-0023 39.979 µM 0.0134143964176879 0.481452865996715 no 1594 0.494648590597547 2385 674768
SGTC_1981 st071826 47 µM 0.0131348717009309 0.48156307619321 no 1595 0.494760095000258 2320 11838600
SGTC_860 0443-0016 25.1 µM 0.0128310225017422 0.481682878574322 no 1596 0.494881303076554 2389 5337942
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0121932067179268 0.481934363458248 no 1597 0.495135734838704 2390 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3319 9138450 16.7555 µM 0.0108064081270633 0.48248119003197 no 1598 0.495688950805283 2375 2029690
SGTC_404 fumagillin 50 µM 0.0102339633827693 0.48270691957122 no 1599 0.495917310576728 2363 12015870 A methionine aminopeptidase binder.
SGTC_313 3474-0040 5.03 µM 0.00981286536247571 0.482872972786216 no 1600 0.496085295941116 2391 1043375 YIL048W NEO1
SGTC_1704 st028805 70.8 µM 0.00978458720785878 0.482884123927339 no 1601 0.496096576751028 2365 2876101
SGTC_772 k072-0172 35.3 µM 0.00874677659411305 0.483293380919858 no 1602 0.496510585493022 2383 5861980
SGTC_1492 4158-0558 28.5 µM 0.00729578904679603 0.483865602208259 no 1603 0.49708942710129 2395 3967268
SGTC_1650 st011916 45.8 µM 0.00711531791456247 0.483936776375515 no 1604 0.497161422797199 2386 242528
SGTC_1511 0906-3109 28.5 µM 0.00704559918760858 0.483964272169602 no 1605 0.497189235847928 2396 2882180
SGTC_1950 st077106 7.18 µM 0.00689379567183433 0.484024140970593 no 1606 0.497249795217721 2378 13831864
SGTC_1376 2910-0861 41.3 µM 0.00586460184707729 0.484430047457669 no 1607 0.497660375776821 2392 1112859
SGTC_447 ml7 120 µM 0.00335989008192041 0.485417953962999 no 1608 0.498659600310752 2396 4216 Selective myosin light chain kinase inhibitor.
SGTC_1039 k821-0043 94 µM 0.00273002820106513 0.485666397928136 no 1609 0.498910877676788 2377 15992768
SGTC_2394 5221648 200 µM 0.0025792046217245 0.48572588990814 no 1610 0.498971047367404 2394 788586
SGTC_3263 9137018 49.47 µM 0.00232146766323383 0.485827554335177 no 1611 0.499073869228404 2394 43844957
SGTC_588 3970-1144 52.9 µM 0.00156877503163242 0.486124459437309 no 1612 0.499374149568152 2394 1888707
SGTC_419 nsc-638432 893 µM 0.0015298409033704 0.486139817499005 no 1613 0.499389682019424 2402 368090
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.00151320271513853 0.486146380650074 no 1614 0.499396319688496 2402 688669
SGTC_2701 st077767 14.721 µM 0.00111869388698059 0.486302000915126 no 1615 0.499553705802745 2405 5721188
SGTC_1023 4482-3888 16 µM 0.000795394089798344 0.486429533204643 no 1616 0.499682683701456 2403 3303168
SGTC_1256 0570-0116 285 µM 0.000348159982700616 0.486605956230335 no 1617 0.499861104265363 2404 410638
SGTC_2853 9015042 58.44 µM 8.83935064359309e-05 0.486708429020792 no 1618 0.499964736093016 2405 6457456
SGTC_1383 3049-0032 20.7 µM 7.03253674717834e-05 0.486715556580687 no 1619 0.499971944237554 2399 712864
SGTC_1123 mangostin 811.285 nM -0.000340816385535488 0.486877745841983 no 1620 0.499864033936589 2409 5281650 An antioxidant.
SGTC_355 1311-2252 105 µM -0.000705604996372989 0.48702165130126 no 1621 0.499718504357043 2407 5338538
SGTC_134 0269-0018 6.916 µM -0.00133043305820519 0.487268143639629 no 1622 0.499469234158419 2406 4378915
SGTC_1961 st076550 68.7 µM -0.00158907762179905 0.487370179383418 no 1623 0.49936605001663 2410 1579337
SGTC_829 1635-0120 117 µM -0.002524398179923 0.487739171871625 no 1624 0.498992911903086 2410 285054
SGTC_2044 5102272 200 µM -0.00265275112140474 0.487789809103415 no 1625 0.498941706659507 2415 592666
SGTC_753 1322-0200 289 µM -0.00326007175128793 0.488029409193457 no 1626 0.498699421845041 2420 5403907
SGTC_3185 9108267 49.47 µM -0.00339151097271488 0.48808126515708 no 1627 0.498646985472346 2415 4910486
SGTC_3211 9128781 49.47 µM -0.00346945573414199 0.488112016352851 no 1628 0.498615890194453 2427 17194361
SGTC_2142 5622915 118.518 µM -0.00384248793331847 0.488259188042095 no 1629 0.498467072873673 2413 5322196
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.00493448094923799 0.488690019101168 no 1630 0.498031434906316 2423 676296 Flavone; oxidizing agent.
SGTC_2812 7970281 58.44 µM -0.00571961981748713 0.488999793196033 no 1631 0.497718214268065 2417 2233435
SGTC_2914 7968218 45.32 µM -0.00597713402493931 0.489101396078742 no 1632 0.497615482720097 2414 2977111
SGTC_518 1021-0119 62.6 µM -0.0067546651783785 0.489408177229195 no 1633 0.497305298961586 2430 1097762
SGTC_2569 tetrandrine 100 µM -0.00698366063430674 0.489498530424996 no 1634 0.497213945147705 2421 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1182 1222-0449 220 µM -0.00759912319109507 0.489741372001408 no 1635 0.496968417642421 2423 658318
SGTC_3055 9094636 49.47 µM -0.0077314871892587 0.48979359904483 no 1636 0.496915613598512 2427 25236176
SGTC_3289 9119912 71.43 µM -0.00774117602337203 0.489797421988216 no 1637 0.496911748428605 2430 17014829
SGTC_2303 7774051 200 µM -0.00831942674222684 0.490025585259339 no 1638 0.49668106720934 2436 2953184
SGTC_3281 9140613 49.47 µM -0.00865659043922115 0.490158623132619 no 1639 0.496546563201174 2429 16013766
SGTC_1412 3909-8563 178 µM -0.00922066964692419 0.490381199648849 no 1640 0.496321537148579 2423 23767530
SGTC_623 k072-0108 16.9 µM -0.0107029695987458 0.490966105291917 no 1641 0.49573021442122 2452 5382803
SGTC_1912 st060209 90.8 µM -0.0125706319608108 0.491703099866814 no 1642 0.494985175494235 2431 688787
SGTC_1683 st010134 710 nM -0.0126265051890792 0.491725148340524 no 1643 0.494962887070062 2428 3818134
SGTC_2367 9070478 135.38 µM -0.0130598978597366 0.491896172906106 no 1644 0.494790002670115 2436 572802
SGTC_387 norethindrone acetate 66.7 µM -0.0136527652154624 0.492130131465711 no 1645 0.494553503914345 2444 541197
SGTC_2777 climbazole 1.536 µM -0.0137143875109315 0.49215444914192 no 1646 0.494528922476696 2436 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1034 k072-0165 12.7 µM -0.0140898281759417 0.492302607906141 no 1647 0.494379157795625 2436 5835461
SGTC_100 0086-0128 49.5915 µM -0.0161265556412079 0.493106372130952 no 1648 0.493566713964961 2435 93297
SGTC_2440 5628896 157.78 µM -0.0168264369521548 0.493382576515071 no 1649 0.493287539621448 2444 5522048
SGTC_1430 4049-0248 69.1 µM -0.0193703415767454 0.494386540496793 no 1650 0.492272834980676 2441 22774488
SGTC_2863 9028737 58.44 µM -0.0194938932540945 0.494435301706857 no 1651 0.492223554298046 2446 6460917
SGTC_2927 9011802 47.9 µM -0.0197592204601604 0.494540016677218 no 1652 0.492117724442601 2467 43912568
SGTC_63 0099-0242 26.702 µM -0.0198132759009677 0.494561350434386 no 1653 0.492096163662668 2445 3898502 YLR359W ADE13
SGTC_386 1509-0011 3.07 µM -0.0204628181079239 0.494817702807314 no 1654 0.491837086356515 2448 3107280
SGTC_2323 6148992 148.28 µM -0.0205036830081478 0.494833830876015 no 1655 0.491820787039691 2469 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_317 4495-0002 170 µM -0.0210785925194494 0.495060730149561 no 1656 0.491591480897986 2468 15991618
SGTC_3104 9120930 49.47 µM -0.0211527435816886 0.495089995433229 no 1657 0.491561905498277 2482 17014836
SGTC_1916 st067606 49.2 µM -0.0215039657614543 0.495228613044817 no 1658 0.491421819987656 2469 19590279
SGTC_2368 9071271 200 µM -0.0221419498368955 0.49548040905135 no 1659 0.491167361769049 2461 27209959
SGTC_2537 larixol 68.93 µM -0.0222841599254575 0.495536535987111 no 1660 0.491110642147089 2449 6708759
SGTC_322 k048-0136 19.3 µM -0.0260877704419825 0.497037759736413 no 1661 0.489593665758886 2497 6823282
SGTC_1030 k029-0042 36.7 µM -0.0266866749953442 0.497274142074756 no 1662 0.489354820580889 2492 6080581
SGTC_930 2810-3379 265 µM -0.0276841206133793 0.497667827135213 no 1663 0.488957044382523 2451 1015764
SGTC_2407 paclitaxel 400 µM -0.028432467874799 0.497963196265949 no 1664 0.488658614521726 2660 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2460 5552655 174.22 µM -0.0285070763861514 0.497992643956983 no 1665 0.488628862092108 2522 5401989
SGTC_1319 1306-0155 43.7 µM -0.0300132475948702 0.498587126030668 no 1666 0.488028243938956 2466 3122360
SGTC_3240 9133527 49.47 µM -0.0301041850058226 0.498623018916898 no 1667 0.487991981546586 2456 17617455
SGTC_391 gliotoxin 8.33 µM -0.0303287407314949 0.498711650837644 no 1668 0.487902437661163 2500 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2425 5628681 7.85 µM -0.0305323310289143 0.498792007779869 no 1669 0.48782125448101 2481 5714958
SGTC_13 0199-0087 65 µM -0.0307743925200161 0.498887549337752 no 1670 0.487724731276623 2467 4589825
SGTC_524 r073-0010 27.8 µM -0.0310097543204909 0.498980446592092 no 1671 0.487630880296068 2465 2772106
SGTC_3232 9132874 49.47 µM -0.0315481514388 0.499192952023929 no 1672 0.487416195970873 2472 3784940
SGTC_2315 7733312 200 µM -0.031936449270528 0.499346213388082 no 1673 0.487261365570547 2468 726316
SGTC_1298 1079-1278 263 µM -0.0331038063400678 0.499806970344655 no 1674 0.486795903697311 2469 2840950
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.033551068471287 0.499983505239145 no 1675 0.486617570990419 2467 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1692 fluoroquinolonic acid 71 µM -0.033592858971703 0.5 no 1676 0.486600908385548 2545 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2889 9059656 51.95 µM -0.0340224314194834 0.499830447242452 no 1677 0.486429631683865 2505 3949838
SGTC_545 4218-0007 221 µM -0.0352416914835775 0.499349204109829 no 1678 0.485943508933889 2504 2840508
SGTC_3331 9141060 1.957 µM -0.0355422039673225 0.499230591658797 no 1679 0.485823696859989 2479 4906567 YPR165W RHO1
SGTC_2980 9014342 25.29 µM -0.0356305548221507 0.499195719537798 no 1680 0.485788472279598 2579 2996599
SGTC_533 1222-0222 6.71 µM -0.0363802273016257 0.49889982375668 no 1681 0.485489590034584 2614 3982874
SGTC_3153 9100258 49.47 µM -0.0383320413881246 0.498129445844839 no 1682 0.484711472109179 2507 25236848
SGTC_1205 4161-2785 76 µM -0.0386335010491708 0.498010460746356 no 1683 0.484591296123692 2578 3498106
SGTC_1450 4112-4260 37.6 µM -0.0399308932795442 0.497498386617537 no 1684 0.484074110731017 2481 1633175
SGTC_788 1182-0090 188 µM -0.0407169337292242 0.497188142392483 no 1685 0.483760780813218 2632 5715185
SGTC_2571 chrysanthemic acid 100 µM -0.0408002077954815 0.497155274844215 no 1686 0.48372758685071 2521 2743 An insecticide.
SGTC_1833 st055984 71 µM -0.0410516881008847 0.497056017877292 no 1687 0.483627344709069 2500 676288
SGTC_89 0302-0250 142.109 µM -0.0411478898246787 0.497018047988294 no 1688 0.483588998175038 2470 4203518 YLR208W SEC13
SGTC_1368 1852-0141 284 µM -0.0425505480640246 0.496464435606271 no 1689 0.483029908341605 2508 2838987
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.0428397538509956 0.496350290362788 no 1690 0.482914637036383 2520 5393153
SGTC_78 0336-0123 156.75 µM -0.0430930798873576 0.496250306570976 no 1691 0.482813667813346 2495 6765896
SGTC_1722 st034304 3.6505 µM -0.0432898254269236 0.496172654371201 no 1692 0.482735250876842 2493 4036148 YLR033W RSC58
SGTC_2322 7413319 38.22 µM -0.0436317514732663 0.496037702181178 no 1693 0.4825989708872 2537 1840400
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0439034814412092 0.495930455469925 no 1694 0.48249067009489 2470 1377
SGTC_726 3448-4391 34.2 µM -0.0439830312659792 0.495899058704516 no 1695 0.482458964932671 2538 1356692
SGTC_1527 coumarin 137 µM -0.0458043039596438 0.495180245205363 no 1696 0.481733114174752 2659 323 A hepatotoxic, DNA x-linker.
SGTC_2400 5203494 178.7 µM -0.0466321176525298 0.494853531641927 no 1697 0.48140321684065 2490 6777674
SGTC_758 0868-0029 16 µM -0.047100425679284 0.494668705839222 no 1698 0.481216594036402 2482 762687
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0475818304559719 0.494478712372573 no 1699 0.481024756410893 2496 803109
SGTC_151 3013-0144 2.285 µM -0.047691028925306 0.494435615765315 no 1700 0.480981241924738 2638 906558 YHR107C CDC12
SGTC_2533 agelasine 13.65 µM -0.0477709181707609 0.494404086468544 no 1701 0.480949407011527 2515 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2528 xanthyletin 44.79 µM -0.0481754805767779 0.494244421361157 no 1702 0.480788195578819 2511 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1694 st024011 44.9 µM -0.0491378169381616 0.493864628236252 no 1703 0.480404733117674 2494 2787533
SGTC_2411 st077133 39.94 µM -0.0509578507383126 0.493146353991699 no 1704 0.479679553561635 2747 1403142 YNL221C POP1
SGTC_2591 skatole 100 µM -0.0519362423324742 0.492760241909929 no 1705 0.479289748013352 2535 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1736 st036774 51 µM -0.0566223269041011 0.490911027678211 no 1706 0.477423024388739 2513 1272247
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.0569964042755859 0.490763417834997 no 1707 0.477274029729597 2521 6708514
SGTC_666 0272-0154 136 µM -0.0574957578767187 0.490566376330623 no 1708 0.477075142622278 2529 6870312
SGTC_778 3456-2434 196 µM -0.057499104082789 0.490565055948381 no 1709 0.477073809884006 2649 5539063
SGTC_1107 amlodipine 47 µM -0.0582465953977993 0.490270105345521 no 1710 0.476776102968746 2540 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_3189 9110682 49.47 µM -0.0583573035931963 0.490226421742651 no 1711 0.4767320117881 2548 17122418
SGTC_26 0302-0163 425.158 µM -0.0592343069425282 0.489880375069856 no 1712 0.476382742308206 2521 3100915
SGTC_499 genistein 192 µM -0.0597380262103909 0.489681621700079 no 1713 0.476182142632495 2503 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_770 0389-1121 67.2 µM -0.0598134935264061 0.489651844652099 no 1714 0.476152089269805 2673 6753108
SGTC_1979 st071809 45.3 µM -0.0603415602142805 0.48944348763817 no 1715 0.475941800983943 2629 4976333
SGTC_2107 5363541 170.161 µM -0.0612659636989801 0.489078756679553 no 1716 0.47557369844762 2512 244052
SGTC_2197 6588183 93.1375 µM -0.0618731516091951 0.488839190671963 no 1717 0.475331924216501 2524 884136
SGTC_1791 st048313 56.1 µM -0.0623846558945736 0.488637379762655 no 1718 0.475128256990054 2514 1204976
SGTC_1624 st003710 6.25 µM -0.0630179514110589 0.48838752089919 no 1719 0.474876104786561 2518 24207033
SGTC_1884 5633444 25 µM -0.0632338544045973 0.488302340097225 no 1720 0.474790143397772 2592 5724239
SGTC_1187 1391-0724 117 µM -0.0636128274640575 0.488152824106244 no 1721 0.474639258795681 2551 6997986
SGTC_2845 9003024 42.97 µM -0.0639306654421408 0.488027428981484 no 1722 0.474512717361833 2623 2990173
SGTC_247 mechlorethamine 29.705 µM -0.0640193162262567 0.487992454214539 no 1723 0.474477423115957 2506 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_907 3448-6986 75.5 µM -0.0642662093296681 0.487895049711958 no 1724 0.474379129431201 2563 590582
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0645960819580407 0.487764909175919 no 1725 0.474247802170487 2556 23847180
SGTC_173 1273-0061 2.693 µM -0.0647533616098691 0.487702860053269 no 1726 0.474185187757022 2594 2847414 YPL266W DIM1
SGTC_114 0364-0001 490.298 µM -0.0650551601878709 0.487583796935736 no 1727 0.474065040874407 2562 4003655
SGTC_928 2764-0428 58.7 µM -0.0656816684548889 0.487336635540934 no 1728 0.473815633673557 2651 662578
SGTC_720 r052-1644 49.9 µM -0.0666132477362379 0.486969130761379 no 1729 0.473444799502057 2581 1422863 YOR257W CDC31
SGTC_2565 isoliquiritigenin 100 µM -0.066696254871369 0.48693638526821 no 1730 0.473411757927351 2639 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1952 st077036 64.1 µM -0.0668986087500601 0.486856559035558 no 1731 0.473331210307859 2515 2937007
SGTC_2364 9055074 200 µM -0.0678892681787822 0.486465763165684 no 1732 0.472936890898066 2560 6470630
SGTC_902 1120-0002 2.07 µM -0.0688855989712532 0.486072743162379 no 1733 0.472540340821943 2545 3280475
SGTC_2225 6654152 15.4 µM -0.0689056563945872 0.48606483130065 no 1734 0.472532358035815 2526 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_569 4130-2812 160 µM -0.0689200009236894 0.48605917295354 no 1735 0.472526648968888 2530 743552
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.0699062791452261 0.485670132152711 no 1736 0.472134127661849 2528 3256 An antibiotic and ribosome inhibitor.
SGTC_892 0929-0076 29 µM -0.0707876977868351 0.485322465099591 no 1737 0.471783361502988 2536 5751038
SGTC_2809 7964133 12.99 µM -0.0721542152502717 0.484783477663396 no 1738 0.471239590544752 2568 1253665
SGTC_2030 5175110 200 µM -0.0723214297678578 0.484717526115164 no 1739 0.471173055430732 2619 2831986
SGTC_2998 9066762 71.4286 µM -0.0731262488083563 0.484400101054147 no 1740 0.470852827021737 2600 4945196
SGTC_940 3232-1287 54.8 µM -0.073189628395757 0.484375104213188 no 1741 0.470827609797337 2527 1585493 YIL048W NEO1
SGTC_2125 5246583 200 µM -0.0744602259882302 0.483873994978658 no 1742 0.470322094169294 2532 835267
SGTC_2009 4012297 12.05 µM -0.0746085175445299 0.483815512120585 no 1743 0.470263098496986 2603 45595307
SGTC_2753 fluvastatin 17.09 µM -0.0760773855414523 0.483236242591203 no 1744 0.469678765856686 2609 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2912 7964298 10.93 µM -0.0763344404751172 0.483134872830341 no 1745 0.469576513115299 2600 2975850
SGTC_2684 capsaicin 100 µM -0.0768653971202788 0.482925493230964 no 1746 0.469365312587323 2618 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3175 9106517 49.47 µM -0.0779413123333474 0.482501226956364 no 1747 0.468937368427852 2601 41468073
SGTC_3062 9077494 49.47 µM -0.0785438903725643 0.482263620631972 no 1748 0.46869770928348 2587 16459633
SGTC_2166 5933061 31.504 µM -0.0823478043579828 0.480763824313356 no 1749 0.467185070546834 2884 2877375
SGTC_3330 9141424 71.43 µM -0.0839941071474786 0.48011480792873 no 1750 0.466530558514126 2632 27261020
SGTC_603 3794-0023 45.9 µM -0.0844946790567512 0.47991747952807 no 1751 0.466331566606072 2562 3802260
SGTC_1427 4048-4900 550 nM -0.0856990285945803 0.479442738090561 no 1752 0.465852837179153 2631 24132586
SGTC_1129 3453-1384 223 µM -0.0857317372878976 0.479429845084505 no 1753 0.465839836146404 2769 1084452
SGTC_2432 5630864 12.22 µM -0.085943897176316 0.479346217114779 no 1754 0.465755507840831 2654 5714970
SGTC_398 bronopol 33.3 µM -0.0859907769223781 0.479327738447484 no 1755 0.465736874509134 2568 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_189 3970-0742 2.116 µM -0.0868833938527462 0.478975902673442 no 1756 0.465382099692642 2567 2891807
SGTC_1647 st011722 22.4 µM -0.0884060419257549 0.478375770448919 no 1757 0.46477697966933 2634 2854783
SGTC_953 1188-0045 9.7 µM -0.0895540948752934 0.477923312436246 no 1758 0.464320782372178 2657 6144426
SGTC_1011 4112-3381 17.4 µM -0.0914323845017968 0.477183123191008 no 1759 0.46357451519952 2733 2877139
SGTC_1334 1486-0610 236 µM -0.091498323198939 0.477157139734748 no 1760 0.463548319271218 2687 3742339
SGTC_1889 st059080 5.18 µM -0.0922932249162855 0.476843912617767 no 1761 0.46323253556505 2551 176925 Isolated from Daphnopsis sellowiana.
SGTC_306 1672-3436 11.6 µM -0.0926799220481751 0.47669154167309 no 1762 0.463078924115515 2646 6797378
SGTC_427 1354-0053 47.3 µM -0.0930980034419005 0.476526808167631 no 1763 0.462912851785693 2818 6813657
SGTC_2917 7979103 53.79 µM -0.0938786992579903 0.476219207156423 no 1764 0.462602757313632 2653 2980565
SGTC_484 loperamide 105 µM -0.0946582856782678 0.475912057397347 no 1765 0.462293126174265 2549 3955 An opioid-receptor agonist.
SGTC_3352 9151559 45.5865 µM -0.0948009021188067 0.475855869396778 no 1766 0.462236485156932 2630 17159339
SGTC_846 0335-0850 148 µM -0.0956533060903065 0.475520049476366 no 1767 0.461897963558868 2577 6819598
SGTC_1364 1653-0028 37.6 µM -0.0964942159921982 0.475188774889735 no 1768 0.461564033730585 2650 5718652
SGTC_2332 7982454 138.89 µM -0.0966332455090323 0.475134006166766 no 1769 0.461508826968304 2554 2981748
SGTC_1005 4092-0690 4.4 µM -0.0967050542183214 0.475105718319546 no 1770 0.46148031298035 2623 1529343
SGTC_1741 st038134 10.228 µM -0.096927282251125 0.475018176076249 no 1771 0.461392071353712 2684 1272587
SGTC_2564 betulinic acid 100 µM -0.0972120986891845 0.47490598015932 no 1772 0.461278980094455 2639 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1391 3442-0225 151 µM -0.0978864757639653 0.474640335063666 no 1773 0.461011219593205 2592 5227075
SGTC_1673 st016611 27.3 µM -0.0993067187224576 0.474080921601405 no 1774 0.460447372009926 2771 5226799
SGTC_2687 chenodiol 100 µM -0.100685557408439 0.473537865572182 no 1775 0.459900038312518 2643 5702181 A cholesterol synthesis inhibitor.
SGTC_194 1486-1323 56.904 µM -0.101663022839782 0.473152920245908 no 1776 0.459512076762903 2597 5178754
SGTC_1870 st057514 26.5 µM -0.103316945289248 0.47250162997989 no 1777 0.458855713596276 2578 5393161
SGTC_1390 3413-2614 145 µM -0.103485820693583 0.472435133443545 no 1778 0.458788701259516 2624 3421432
SGTC_41 0478-0632 82.643 µM -0.103966462192441 0.472245879810913 no 1779 0.458597981796434 2581 3750424
SGTC_610 4215-0184 155 µM -0.104828272237522 0.471906555954668 no 1780 0.458256037819986 2643 5605015
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.105210507071247 0.471756063644081 no 1781 0.45810438677993 2581 97141
SGTC_1299 1079-1439 3.74 µM -0.105355546813926 0.471698960101659 no 1782 0.458046844096074 2611 323161
SGTC_1679 SEC14.276 6.7 µM -0.105428872876712 0.471670091146456 no 1783 0.458017753242442 2741 1005053 YMR079W SEC14
SGTC_3151 9099821 49.47 µM -0.106435155498024 0.47127392613509 no 1784 0.457618550714809 2700 17174189
SGTC_589 1227-0070 34.1 µM -0.107166764516737 0.470985915635282 no 1785 0.457328340811393 2688 2841384
SGTC_3325 9138760 55.175 µM -0.107331432759052 0.470921093230313 no 1786 0.457263024416293 2627 43844959
SGTC_828 2074-0507 139 µM -0.107578038374551 0.470824017245923 no 1787 0.457165209354978 2699 X828
SGTC_283 0987-0079 11.7 µM -0.110639444710306 0.469619044739718 no 1788 0.455951133566487 2631 411556
SGTC_1520 flindersine 88 µM -0.110674703995485 0.469605168250114 no 1789 0.455937153005321 2879 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_369 0957-0393 4.5 µM -0.110745951331634 0.46957712857372 no 1790 0.455908903088609 2639 6997992
SGTC_1640 st009078 66.4 µM -0.111422108632485 0.469311031671498 no 1791 0.455640814532369 2673 690618
SGTC_2371 9071574 200 µM -0.111606328032835 0.469238535806173 no 1792 0.455567777164745 2587 45596039
SGTC_380 3970-0968 6 µM -0.111865114649959 0.469136697225264 no 1793 0.455465178709314 2606 2891601
SGTC_2959 9079155 11 µM -0.112471016280425 0.468898268685266 no 1794 0.455224974781646 2744 16189457
SGTC_1969 st069479 40.1 µM -0.11287296482411 0.468740103936905 no 1795 0.455065635137434 2703 3895485
SGTC_2089 5281248 129.67 µM -0.113029104173205 0.468678665210422 no 1796 0.455003740634532 2607 2737878
SGTC_783 0848-0141 92.7 µM -0.114082446806732 0.468264208663376 no 1797 0.45458621839498 2596 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2595 hexamethylquercetagetin 100 µM -0.114418634522922 0.468131936797249 no 1798 0.454452971394514 2703 386331
SGTC_3024 9090631 49.47 µM -0.114464694898818 0.468113814779202 no 1799 0.454434715900533 2603 25236383
SGTC_2245 6637752 200 µM -0.114652117788201 0.468040075702798 no 1800 0.454360434012398 2755 681890
SGTC_256 clotrimazole 625 nM -0.115148623276348 0.46784473744073 no 1801 0.454163660192621 2589 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_204 PMA1.184 62.41 µM -0.115211707706722 0.467819918927076 no 1802 0.454138659532604 2580 2252213 YGL008C PMA1
SGTC_1058 3448-5425 97.3 µM -0.116605834500273 0.467271477264058 no 1803 0.45358620700373 2598 7279705
SGTC_2721 ifenprodil 61.44 µM -0.116873760564875 0.467166083737657 no 1804 0.453480045830894 2705 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2723 salbutamol 83.58 µM -0.117089911947755 0.46708105838889 no 1805 0.453394401922621 2685 9884233 β2-adrenoceptor agonist
SGTC_43 0570-0105 72.5 µM -0.117093805485562 0.467079526839883 no 1806 0.453392859237595 2625 1114046 YDL195W SEC31
SGTC_3200 9114385 49.47 µM -0.118227075737313 0.466633768254432 no 1807 0.452943868533233 2733 17018030 YLR208W SEC13
SGTC_1550 gossypolone 36.6 µM -0.119005144136507 0.466327748354319 no 1808 0.452635640157406 2628 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2985 9022375 71.43 µM -0.121908043153765 0.465186194407274 no 1809 0.451485922813699 2819 4939335
SGTC_2311 7694451 200 µM -0.122597518539575 0.464915102592367 no 1810 0.451212909769754 2695 2163142
SGTC_1246 0422-0085 105 µM -0.123351451622184 0.464618685580004 no 1811 0.45091439969137 2656 264295
SGTC_646 4092-0839 27.3 µM -0.12352916596032 0.464548818103604 no 1812 0.450844040028398 2723 877796
SGTC_1848 st056003 16.4 µM -0.124171580534717 0.464296265256521 no 1813 0.450589711756359 2603 146492
SGTC_456 gingerol 170 µM -0.124414471273629 0.464200781209069 no 1814 0.450493557975444 2774 442793 A herb.
SGTC_2340 7987427 183.45 µM -0.125121525745604 0.463922839087746 no 1815 0.45021367106533 2724 2239331
SGTC_649 1123-0311 367 µM -0.127310486836327 0.463062473777643 no 1816 0.449347330275704 2707 693629 YIL048W NEO1
SGTC_1235 benzylparaben 21.5 µM -0.128644538053297 0.462538212976542 no 1817 0.448819461410619 2707 7180
SGTC_2585 alliin 100 µM -0.129006852596874 0.462395840350895 no 1818 0.448676113277216 2761 87310 A garlic compound which reacts with lipids.
SGTC_1160 4092-0570 10.5 µM -0.129363291511743 0.462255781272785 no 1819 0.448535096347998 2617 4994975
SGTC_24 0417-1663 219 µM -0.130772564641758 0.461702067600789 no 1820 0.447977613413383 2701 4329390
SGTC_1859 st055998 20 µM -0.132489559249141 0.46102754832909 no 1821 0.447298540369107 2643 676301
SGTC_1648 st011736 69.8 µM -0.133825284764577 0.460502887592717 no 1822 0.446770366342776 2766 2855514
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.134866167272687 0.460094086103822 no 1823 0.446358844856525 2781 5282362
SGTC_2825 7998094 58.44 µM -0.13650791762205 0.459449382622612 no 1824 0.445709882892666 2726 2987815
SGTC_308 4092-1169 104 µM -0.136924181614001 0.459285935642201 no 1825 0.445545362344441 2670 2268590 YDL196W YDL196W
SGTC_713 1488-1073 324 µM -0.137779686952276 0.458950041207199 no 1826 0.445207269348618 2623 3312542
SGTC_3292 9120825 59.784 µM -0.138181360007707 0.458792343643369 no 1827 0.445048543163655 2664 24824900
SGTC_3065 9113888 49.47 µM -0.138619731661915 0.458620245544989 no 1828 0.444875325118143 2809 16648368
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.139728210351745 0.458185108206965 no 1829 0.444437368209244 2771 5377381
SGTC_1529 apigenin 74 µM -0.142091921146523 0.457257392944057 no 1830 0.443503699710234 2858 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2598 perillyl alcohol 100 µM -0.142371752892107 0.457147579182382 no 1831 0.443393186503719 2796 10819 An apoptosis inducer.
SGTC_861 0443-0273 110 µM -0.142611573030385 0.457053469691842 no 1832 0.443298478477953 2741 6149169
SGTC_1701 st028638 40.4 µM -0.143371955663691 0.456755098596476 no 1833 0.44299821513714 2678 3490878
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.144422159887156 0.456343042793741 no 1834 0.442583559592381 2659 364106
SGTC_1421 4029-0249 71.4 µM -0.144630973671679 0.456261118660686 no 1835 0.4425011204484 2793 2894095
SGTC_1808 st050063 61.5 µM -0.14463742558474 0.456258587404402 no 1836 0.442498573289385 2711 4011993
SGTC_12 0849-0099 9.267 µM -0.144675433640412 0.456243675874073 no 1837 0.44248356808869 2629 6071388
SGTC_257 daunorubicin 18.5 µM -0.146178284005145 0.455654118924861 no 1838 0.441890324127471 2792 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1392 3455-1037 33.9 µM -0.146800599036951 0.455410017907844 no 1839 0.441644705922183 2804 981132
SGTC_1841 st054148 70 µM -0.147727358694756 0.45504653071827 no 1840 0.44127896970511 2742 675442
SGTC_201 4262-0159 12.803 µM -0.147990416301073 0.454943362948096 no 1841 0.441175165821718 2766 1341029
SGTC_2967 9089538 49.85 µM -0.149011629379358 0.454542885328134 no 1842 0.440772228250638 2869 728216
SGTC_901 1112-0062 60.1 µM -0.149261075399994 0.454445069900088 no 1843 0.44067381423984 2671 1908457
SGTC_1341 1486-1360 280 µM -0.150002705284016 0.454154270437105 no 1844 0.440381240451345 2656 3976547
SGTC_954 1189-0853 2.85 µM -0.150877928984685 0.453811119312467 no 1845 0.440036005638424 2629 2828194
SGTC_2793 7325131 81.82 µM -0.151278397306263 0.453654118187277 no 1846 0.439878054802309 2754 4176441
SGTC_1719 st032227 49.2 µM -0.152510412515438 0.453171159775464 no 1847 0.439392189252563 2713 3125804
SGTC_762 1165-0429 115 µM -0.153577102212443 0.452753066011985 no 1848 0.438971596254559 2814 5967793
SGTC_2490 carminic acid 95.39 µM -0.15499994377172 0.45219545854958 no 1849 0.438410680816741 2630 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_426 0988-0037 14.6 µM -0.155139223247855 0.452140880377034 no 1850 0.438355780412465 2648 5383008
SGTC_1219 1469-0211 33.1 µM -0.155650765552641 0.451940434748165 no 1851 0.438154153717428 2721 6822282
SGTC_3327 9140648 26.9345 µM -0.155759699949336 0.451897750858696 no 1852 0.438111218807664 2775 8029710
SGTC_988 1497-1057 103 µM -0.155770343610336 0.451893580370621 no 1853 0.438107023802381 2678 3533044
SGTC_3155 9099265 49.47 µM -0.157073543626339 0.451382989921503 no 1854 0.437593443933703 2796 25236499
SGTC_777 1315-0167 517 µM -0.157434551160307 0.451241562277459 no 1855 0.437451192539843 2779 4221767
SGTC_1192 1488-0095 21.4 µM -0.157510750113731 0.45121171150679 no 1856 0.437421168140075 2758 915875
SGTC_1222 0366-0074 1.18 µM -0.157564327623652 0.45119072280153 no 1857 0.437400057402146 2805 286520
SGTC_2216 7189485 200 µM -0.157608163321357 0.451173550501016 no 1858 0.437382785288795 2775 731273
SGTC_1175 0741-0056 27.6 µM -0.157785653171202 0.451104021139324 no 1859 0.437312852072664 2854 765927
SGTC_2346 9031566 143.75 µM -0.15925324484567 0.450529168693523 no 1860 0.4367346778821 2806 4771086
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.159946855450678 0.450257518973516 no 1861 0.436461469154119 2770 688761
SGTC_1625 st003711 30.1 µM -0.160675986626839 0.449971982894918 no 1862 0.43617430178167 2851 24207034 YER133W GLC7
SGTC_3041 9091929 49.47 µM -0.161176686137695 0.449775918249057 no 1863 0.435977121399334 2819 25236887
SGTC_3307 9126885 69.2785 µM -0.161206038120268 0.44976442493679 no 1864 0.435965562793742 2701 24824909
SGTC_1245 0418-0076 17.2 µM -0.16210100274725 0.449414005241567 no 1865 0.435613158281419 2873 6790114
SGTC_1206 3978-0017 132 µM -0.162954736258667 0.449079766178265 no 1866 0.435277036721295 2981 3873677
SGTC_1443 4112-3303 14 µM -0.16397084167399 0.448682005170757 no 1867 0.434877049035456 2706 704433
SGTC_3282 9108498 15.4605 µM -0.165570106318639 0.448056067353093 no 1868 0.434247637121163 2797 16459645
SGTC_2570 licareol 100 µM -0.167233999240308 0.447404971881185 no 1869 0.433592966786942 2818 443158
SGTC_261 5-fluorouridine 15.376 µM -0.167698698615192 0.447223156297637 no 1870 0.433410160023051 2903 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1785 bathophenanthroline 24 µM -0.168064730770162 0.447079952485062 no 1871 0.433266177703527 2717 72812 An iron chelator.
SGTC_698 k064-0052 127 µM -0.169235230736581 0.446622060815946 no 1872 0.432805809661212 2671 5088751
SGTC_1975 st070967 30.8 µM -0.169256236924724 0.44661384398539 no 1873 0.432797548571746 2773 261391
SGTC_1907 st060210 83.7 µM -0.170194033038685 0.44624703682991 no 1874 0.432428772103509 2871 688793
SGTC_775 4577-0580 57.3 µM -0.171276808789432 0.445823579940668 no 1875 0.432003057451899 2927 2006902
SGTC_2256 7954252 200 µM -0.172277036163531 0.445432461340277 no 1876 0.431609868457509 2779 2972920
SGTC_1840 st055363 71 µM -0.172460341990506 0.445360789066141 no 1877 0.431537818341932 2755 676033
SGTC_2040 5100729 123 µM -0.17279446070201 0.445230153800217 no 1878 0.431406495634966 2707 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1283 0922-0125 16.4 µM -0.173504361153097 0.444952613425829 no 1879 0.431127500083357 2825 3360884
SGTC_1644 st010134 20.9 µM -0.173543924778623 0.444937146551834 no 1880 0.431111952327638 2742 3818134
SGTC_2724 maprotiline 69.64 µM -0.17380070707734 0.444836762960916 no 1881 0.431011044342164 2721 4011 A tricyclic antidepressant.
SGTC_2932 9016711 44.54 µM -0.174841386652519 0.444429967650812 no 1882 0.430602133670393 2788 7117328
SGTC_2408 sulbentine 18.36 µM -0.175736002112256 0.4440803146807 no 1883 0.430250674922805 2817 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_897 1000-0139 31.4 µM -0.176502808542055 0.443780649428747 no 1884 0.429949471211686 2870 6151020
SGTC_450 aminopyrene 156 nM -0.17687844827083 0.443633862464934 no 1885 0.429801933740137 2763 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2274 7947094 46.08 µM -0.176913588072102 0.443620131445893 no 1886 0.429788132619512 2700 2971028
SGTC_765 1319-0117 244 µM -0.178149435133217 0.443137262394296 no 1887 0.429302809652949 2722 3487746 YGL099W LSG1
SGTC_71 0417-1750 47.813 µM -0.178271234695235 0.443089677538239 no 1888 0.429254984162812 2927 6811472
SGTC_3162 9099653 49.47 µM -0.178819037988706 0.442875670990866 no 1889 0.429039898035337 2733 25237511
SGTC_1081 sertraline 6 µM -0.179153485459818 0.442745022885088 no 1890 0.428908592984098 2828 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3231 9132313 49.47 µM -0.180384243416418 0.442264294985838 no 1891 0.428425461680472 2777 4905967
SGTC_2108 5365811 200 µM -0.182141415919733 0.441578099690697 no 1892 0.427735873555089 2832 780283
SGTC_2086 5274770 176.623 µM -0.183133875757636 0.441190610485999 no 1893 0.427346488108447 2796 689278
SGTC_597 k018-0003 82.8 µM -0.184189109592619 0.440778673982664 no 1894 0.426932551304004 2845 6786234
SGTC_982 1491-0518 27.5 µM -0.185015315197889 0.440456188987039 no 1895 0.426608511580965 2763 3091256
SGTC_292 k038-0015 474 µM -0.186753698982898 0.439777791343658 no 1896 0.425926875491955 2854 46368540
SGTC_3098 9119039 49.47 µM -0.187018398079045 0.439674508990559 no 1897 0.425823103930269 2733 17161528
SGTC_2667 digitoxin 100 µM -0.187532142425112 0.439474063947279 no 1898 0.42562171234398 2818 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1089 terbinafine 2.25 µM -0.187867160465777 0.439343360001381 no 1899 0.425490393240475 2866 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_228 caffeine 993.056 µM -0.188387413115334 0.439140401733272 no 1900 0.425286482963976 2872 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_128 0906-2981 13.371 µM -0.189311660188267 0.438779878744344 no 1901 0.424924278529127 2882 6740226
SGTC_737 1950-0117 57.9 µM -0.189993333148387 0.43851400967232 no 1902 0.42465717737913 2788 5393513
SGTC_202 3594-0513 34.79 µM -0.190618595184367 0.438270166628526 no 1903 0.424412210236328 2718 708429
SGTC_1750 st081859 2.357 µM -0.190660545909581 0.438253807297455 no 1904 0.424395775692278 2761 5291695
SGTC_3084 9116877 49.47 µM -0.192358375235948 0.437591801469101 no 1905 0.423730747614718 2723 27241325
SGTC_2813 7971799 71.43 µM -0.193302407785071 0.437223786285103 no 1906 0.423361070376184 2872 2234054
SGTC_192 3455-0609 60.9 µM -0.19413685919288 0.436898534671133 no 1907 0.423034360580146 2869 3769639
SGTC_1958 st076513 41.9 µM -0.197159893276225 0.4357205782509 no 1908 0.421851207534478 2743 732122 YGL099W LSG1
SGTC_1978 st071761 42 µM -0.19787580915668 0.435441697338122 no 1909 0.421571115716669 2781 5147680
SGTC_2088 5278280 127.392 µM -0.198241094304774 0.435299414970917 no 1910 0.421428218420654 2845 791502
SGTC_2995 9067767 71.4286 µM -0.198321478666981 0.435268105548972 no 1911 0.421396773942586 2845 11673567
SGTC_2502 avocadyne acetate 18.59 µM -0.200184417542549 0.434542611594682 no 1912 0.420668176758564 2706 3952079
SGTC_2382 9035899 200 µM -0.201377641321738 0.434078043888037 no 1913 0.420201648366488 2785 6462679
SGTC_2543 pimpinellin 60.67 µM -0.201458618658781 0.434046519601524 no 1914 0.420169991782212 2776 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2468 5987765 72.9 µM -0.201577025970686 0.434000424669133 no 1915 0.420123703574928 2809 26772094
SGTC_3246 9135460 32.98 µM -0.202603587379791 0.433600830962886 no 1916 0.419722442916522 2858 41446951
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.202625467051171 0.433592314938234 no 1917 0.419713891532859 3049 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_506 n9-isopropylolomoucine 153 µM -0.202876552761178 0.433494589348501 no 1918 0.419615760678828 2896 6610355
SGTC_378 3970-0959 8.33 µM -0.203709278537094 0.433170511558083 no 1919 0.419290345506074 2896 6615653
SGTC_510 ag-490 170 µM -0.203965776486701 0.433070697475847 no 1920 0.419190121547639 2825 5328779
SGTC_538 2922-0838 53.3 µM -0.204197920251251 0.432980364306378 no 1921 0.419099418258649 2879 777039
SGTC_1291 0993-0025 5.79 µM -0.206119718265958 0.432232677698986 no 1922 0.418348698261949 2894 4353356
SGTC_705 1124-0212 310 µM -0.206125204256769 0.43223054368864 no 1923 0.418346555670723 2836 9554485
SGTC_1445 4239-0156 97.7 µM -0.206577328863718 0.432054677321367 no 1924 0.418169983647458 2951 4008346
SGTC_160 3453-0671 289.699 µM -0.206736912744434 0.431992605971317 no 1925 0.418107663948879 2808 5322268
SGTC_926 2268-1401 59.4 µM -0.206977237366937 0.431899133071013 no 1926 0.418013817760999 2761 2931578
SGTC_979 1426-2828 121 µM -0.207779526065219 0.431587115063965 no 1927 0.417700559783434 2903 747872
SGTC_1073 triclabendazole 3.09 µM -0.208148146440433 0.431443769253413 no 1928 0.417556647452129 2847 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3209 9113616 49.47 µM -0.208355597360892 0.431363101554845 no 1929 0.417475661814333 2950 16649353
SGTC_2182 6325192 200 µM -0.208380137444036 0.431353559284516 no 1930 0.41746608197606 2755 736248
SGTC_1190 1486-1332 13 µM -0.210782207534982 0.43041972287475 no 1931 0.416528611480949 2760 4150046
SGTC_478 N-arachidonylglycine 10 µM -0.212566507712996 0.429726304159806 no 1932 0.415832548682827 2768 5283389
SGTC_1755 st041960 45.185 µM -0.213037168955801 0.429543430775184 no 1933 0.415648985715961 2913 2257073
SGTC_1038 k292-0204 154 µM -0.21370744385123 0.429283024475789 no 1934 0.415387603046967 2756 4454212
SGTC_449 xestospongin c 11.1929 µM -0.213881781433281 0.42921529819221 no 1935 0.415319623903547 2909 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1439 4092-1168 46 µM -0.215079995442336 0.428749875104986 no 1936 0.414852475127448 2814 2886240
SGTC_505 gw-5074 63.9 µM -0.216520559626478 0.428190446970003 no 1937 0.414291000483841 2896 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_701 4424-0219 185 µM -0.21690591118273 0.428040824111219 no 1938 0.41414083540742 2936 2911779
SGTC_1739 st037196 92.5 µM -0.217414755287703 0.427843267881428 no 1939 0.413942566576065 2944 612214
SGTC_2345 9052315 157.45 µM -0.217718759706692 0.427725248283623 no 1940 0.413824123076069 2884 6469265
SGTC_2057 5236571 38.335 µM -0.218236959955935 0.427524089194499 no 1941 0.413622244576015 2931 54684039 YBR257W POP4
SGTC_1043 0916-0009 19.3 µM -0.218496155670364 0.427423479608216 no 1942 0.41352127664842 2970 3101130
SGTC_1563 conessine 56.1 µM -0.218524085346495 0.427412638687549 no 1943 0.413510397174204 2918 441082 An anti-amoebic, histamine inhibitor.
SGTC_1133 3473-0247 50 µM -0.221716794791656 0.426173749819518 no 1944 0.412267177568663 2865 711311
SGTC_528 3492-0019 172 µM -0.222247224608992 0.425967993727195 no 1945 0.412060716657288 2858 2869262
SGTC_2931 9014674 55.67 µM -0.223383936082576 0.425527126216334 no 1946 0.411618352811212 2822 2996810
SGTC_2281 7943571 200 µM -0.223796164345221 0.425367268645728 no 1947 0.411457957343918 2969 1244024
SGTC_872 0588-0139 234 µM -0.223923846211335 0.425317757514523 no 1948 0.411408280119627 2799 2047100
SGTC_708 3448-5400 146 µM -0.226060700445332 0.42448932603703 no 1949 0.410577104949467 2861 3462195
SGTC_1469 k284-2957 126 µM -0.226075975422263 0.424483405316873 no 1950 0.41057116486107 2846 23884841
SGTC_217 ketoconazole 989 nM -0.22619811332125 0.42443606416796 no 1951 0.410523668969656 2878 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_756 0508-1999 28.3 µM -0.226466703702708 0.424331961273574 no 1952 0.410419226566038 2824 6753853
SGTC_3344 9148862 3.898 µM -0.227471941854054 0.423942388118054 no 1953 0.410028392280086 2949 4905352
SGTC_203 k066-0004 30.888 µM -0.227994670086086 0.423739837719906 no 1954 0.409825192034792 2784 6795412
SGTC_466 geldanamycin 89.2 µM -0.228694959263846 0.423468516345801 no 1955 0.409553006449895 2877 5288382 HSP90 inhibitor.
SGTC_2950 9072895 21.46 µM -0.229335633251365 0.423220324173466 no 1956 0.409304030034334 2934 17332245
SGTC_2752 diclazuril 33.15 µM -0.22947591063512 0.423165985856645 no 1957 0.409249520821138 2974 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2625 euphol 100 µM -0.231041984738404 0.422559445620486 no 1958 0.408641092582401 2955 6708538 A triterpene alcohol.
SGTC_2568 diosmetin 100 µM -0.231636812187 0.422329117074569 no 1959 0.408410056510134 2936 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2360 9040895 200 µM -0.231836123617885 0.422251945819318 no 1960 0.408332649360358 2884 4914414
SGTC_981 1488-1094 54.9 µM -0.23271400450554 0.421912075288372 no 1961 0.407991746863001 2773 3449522
SGTC_2670 beta-carotene 100 µM -0.233859000964328 0.42146887870385 no 1962 0.407547221575908 2932 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1866 st057638 64 µM -0.23420406985831 0.421335331521828 no 1963 0.407413277794241 2835 688802
SGTC_1290 0986-0249 10.2 µM -0.234967994926544 0.421039712512588 no 1964 0.40711678709583 2883 53329
SGTC_1086 cerivastatin 2.18 µM -0.235382300413912 0.420879405737402 no 1965 0.406956011210458 2806 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2934 9036370 36.88 µM -0.23539339263917 0.420875114014843 no 1966 0.406951706963571 2928 6462800
SGTC_1619 st003326 88.7 µM -0.235919440655172 0.420671590175803 no 1967 0.406747591266355 2993 2849032
SGTC_245 methotrexate 289.6 µM -0.238398400151516 0.419712786508354 no 1968 0.405786054078136 2895 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1548 st061468 90.8 µM -0.239754183759111 0.419188602218424 no 1969 0.405260413571173 2950 390799
SGTC_2437 5741531 144.16 µM -0.240733829885855 0.418809932506269 no 1970 0.404880708717906 3018 2262990
SGTC_2441 5730946 39.09 µM -0.241528380066988 0.418502864490933 no 1971 0.404572811665472 2956 1774275
SGTC_2475 5812728 15.03 µM -0.242021226454646 0.418312420200908 no 1972 0.40438185787423 2794 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3233 9132340 49.47 µM -0.242128237825468 0.418271071702098 no 1973 0.404340399227066 2856 17682950
SGTC_1302 1159-0335 255 µM -0.2429469475504 0.417954757501542 no 1974 0.404023247975808 2829 649284
SGTC_1940 st075990 51.1 µM -0.243412354851477 0.417774967795665 no 1975 0.40384298689924 3078 1084979
SGTC_721 1187-1332 279 µM -0.24473363984342 0.417264641036171 no 1976 0.403331339555904 2783 25730
SGTC_2171 5739187 198.077 µM -0.248334251796059 0.415874667657367 no 1977 0.401937899870654 2786 2262761
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.248944830371768 0.415639064888278 no 1978 0.40170172851285 2832 23665772 A membrane-active detergent.
SGTC_2850 9015429 58.44 µM -0.249132877242675 0.415566509711021 no 1979 0.40162899934335 2904 6457570
SGTC_1735 st034310 56.75 µM -0.249453300278305 0.415442885729403 no 1980 0.401505080104997 3051 871153
SGTC_1414 3917-0015 5.4 µM -0.250560960446996 0.415015598480327 no 1981 0.401076784017526 2913 6618702
SGTC_23 0213-0011 39.996 µM -0.250647307815706 0.414982293627222 no 1982 0.401043401291471 3016 627608
SGTC_748 act1.228 77.9 µM -0.2506767997848 0.414970918484851 no 1983 0.401031999577113 2832 4421505 YNR035C ARC35
SGTC_693 4161-2696 114 µM -0.251064862876639 0.414821248011218 no 1984 0.400881980673815 2951 805759
SGTC_2805 7950783 58.44 µM -0.251895722666852 0.4145008386819 no 1985 0.400560832914224 2979 1178958 YDL195W SEC31
SGTC_1264 0783-0040 158 µM -0.252493786765748 0.414270238915202 no 1986 0.400329708005986 2806 2855798
SGTC_1369 1866-0067 208 µM -0.254272442827176 0.413584604946818 no 1987 0.399642543871542 2980 3531355
SGTC_352 k048-0007 5.11 µM -0.255178197414509 0.413235556958825 no 1988 0.399292734856264 2932 6811911
SGTC_2657 nystatin 74.44 µM -0.255305999774459 0.413186311652095 no 1989 0.399243383156445 2913 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1184 1269-1718 139 µM -0.255569784110313 0.413084673556684 no 1990 0.399141526238278 3001 5403821
SGTC_162 k030-0015 37.8 µM -0.257576953578341 0.41231148728921 no 1991 0.398366709025626 2939 1809920 YMR134W ERG29
SGTC_1727 st034309 9.9045 µM -0.257593840540094 0.412304983663662 no 1992 0.398360191934183 3130 870305
SGTC_236 1509-0011 5.31 µM -0.25801786470284 0.412141688392409 no 1993 0.398196559939398 2962 3107280
SGTC_1303 1160-0052 261 µM -0.259512509531341 0.411566209581297 no 1994 0.397619915673039 2882 3562476
SGTC_486 niguldipine 82 µM -0.259935337870212 0.411403443657658 no 1995 0.397456826115939 2846 1236 A calcium channel blocker.
SGTC_1815 st051655 58.2 µM -0.260113668099621 0.411334800783961 no 1996 0.397388047550512 2963 5984156
SGTC_1666 st014829 29 µM -0.260692087427526 0.41111217429981 no 1997 0.397164984223033 2819 3858230
SGTC_951 1171-0579 82.7 µM -0.262300546465454 0.410493248885437 no 1998 0.396544870376373 2812 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_491 tetrandrine 80.3 µM -0.262540443902701 0.410400956846163 no 1999 0.39645240440557 2972 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_739 1486-1183 203 µM -0.263129199817524 0.410174474908938 no 2000 0.396225499259088 2995 4346692
SGTC_2262 9014885 67.46 µM -0.264639856273752 0.409593494570398 no 2001 0.39564345678138 2874 6457424
SGTC_1798 st045719 60.953 µM -0.265733896645709 0.409172863613999 no 2002 0.395222077950001 2870 3980186
SGTC_468 gf-109203x 121 µM -0.266062136409912 0.409046684064656 no 2003 0.395095677516059 2950 2396 A protein kinase C inhibitor.
SGTC_3266 9136860 49.47 µM -0.266611224714319 0.408835628596397 no 2004 0.394884256154602 2936 4871271 YPR165W RHO1
SGTC_767 0929-0023 86 µM -0.267021731517412 0.408677857568273 no 2005 0.394726214529991 2897 1204563
SGTC_1056 3448-1962 115 µM -0.267222546617771 0.4086006832253 no 2006 0.39464890873405 2973 715507
SGTC_1946 st076057 65.1 µM -0.26773936200569 0.408402084545354 no 2007 0.394449974526762 2856 953009
SGTC_793 0488-0545 106 µM -0.269340349707638 0.407787016229212 no 2008 0.393833892218391 2872 292548
SGTC_3328 9140624 29.0385 µM -0.270313823300381 0.407413137598453 no 2009 0.393459415812172 3055 4904392
SGTC_2305 7443522 69.23 µM -0.271015064976342 0.407143866368466 no 2010 0.393189722774797 2874 5415886
SGTC_2431 5490079 200 µM -0.273296135377406 0.406268257620165 no 2011 0.39231279291072 2946 5722345
SGTC_2354 9060492 162 µM -0.2737493965722 0.406094325025058 no 2012 0.392138607091596 3031 6471895
SGTC_1875 nocodazole 6 µM -0.275361409977811 0.405475887982647 no 2013 0.391519294418623 2950 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2296 7971656 126.45 µM -0.276134734478192 0.405179291378366 no 2014 0.391222291579496 2968 666570
SGTC_1064 honokiol 6.76 µM -0.276993241236676 0.404850088224656 no 2015 0.390892647946319 2970 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1942 st076330 65.2 µM -0.278132572077275 0.404413304222934 no 2016 0.390455296445965 3057 24208414
SGTC_608 k048-0125 159 µM -0.27873876997572 0.404180955317164 no 2017 0.390222653527542 3015 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3142 9086498 49.47 µM -0.278960168178843 0.404096104272105 no 2018 0.390137696475732 3027 25236367
SGTC_2834 9001755 58.44 µM -0.279652947264958 0.403830625277486 no 2019 0.389871890523128 2962 2989575
SGTC_1717 st033143 58.0435 µM -0.279668837069126 0.403824536684967 no 2020 0.389865794515829 3069 674616
SGTC_583 1488-1091 88.9 µM -0.281039950622484 0.403299246711989 no 2021 0.389339878989827 2982 4303273
SGTC_2764 methyldopa 94.69 µM -0.281854632500188 0.402987214907021 no 2022 0.389027488849847 3078 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3270 9137563 49.47 µM -0.284916685310508 0.401814970136648 no 2023 0.387853986268803 3012 17015724
SGTC_384 k007-0144 5.16 µM -0.285076073769788 0.401753975582289 no 2024 0.387792930092683 2957 6824886
SGTC_1558 st069300 45.6 µM -0.285198421923524 0.401707157184105 no 2025 0.387746064651554 3014 24208000
SGTC_2162 5663267 200 µM -0.286164369779784 0.401337572004459 no 2026 0.387376115948789 3069 6456493
SGTC_1000 4048-0884 8.67 µM -0.286582178540806 0.401177739842972 no 2027 0.387216130886151 3037 13040088
SGTC_2022 5136654 200 µM -0.287329778064984 0.40089178796644 no 2028 0.386929911953201 3066 1713771
SGTC_2748 diazoxide 86.69 µM -0.287457836534648 0.400842811770118 no 2029 0.386880890853097 2991 3019 A potassium channel activatior.
SGTC_2860 9025725 38.96 µM -0.287801190068568 0.400711503275424 no 2030 0.386749463175337 2876 40546248
SGTC_3351 9150312 21.596 µM -0.288199857434443 0.400559055219316 no 2031 0.386596878954774 2962 4904905
SGTC_2013 4024628 200 µM -0.288249239337207 0.40054017292391 no 2032 0.386577979958984 3070 5230760
SGTC_2676 harmalol 100 µM -0.289178270259353 0.400184980153818 no 2033 0.386222479819574 3024 5459187 A monoamine oxidase inhibitor
SGTC_1055 3448-0672 86 µM -0.289197708019524 0.400177549471391 no 2034 0.386215042844463 3053 748378
SGTC_2204 7233102 200 µM -0.290327402465103 0.39974575114616 no 2035 0.385782888535182 2928 2172480
SGTC_916 4466-0038 42 nM -0.290633752686666 0.399628677302732 no 2036 0.385665721456081 3109 5722064 YGL116W CDC20
SGTC_1032 k061-1018 98.7 µM -0.29119609540492 0.399413797658453 no 2037 0.385450674330855 3113 4005393
SGTC_1230 0170-0365 3.77 µM -0.292372332920306 0.398964438127731 no 2038 0.38500097982463 3028 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_222 nsc-310342 10.666 µM -0.292674625414463 0.398848974537294 no 2039 0.384885433498366 2998 432556
SGTC_919 tnp00227 403.569 nM -0.293356633194744 0.398588507486452 no 2040 0.384624784821378 2942 1269246 A methoxyflavone. YNL221C POP1
SGTC_1623 st003709 20.3 µM -0.293864507102854 0.398394573608622 no 2041 0.384430720224369 2909 16192618
SGTC_111 0083-0039 52.457 µM -0.294625690794132 0.398103959278507 no 2042 0.384139917223259 2886 759313
SGTC_964 1287-0107 19.4 µM -0.295187624643917 0.397889453324472 no 2043 0.383925277562768 3092 51516812 YPR165W RHO1
SGTC_2480 5767542 37.17 µM -0.295994835939339 0.397581372097271 no 2044 0.383617012558476 2959 2867358
SGTC_2790 5423970 71.43 µM -0.296584373684287 0.397356408763753 no 2045 0.383391921182479 3118 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1571 st070080 73.4 µM -0.296726261437774 0.397302270518956 no 2046 0.38333775289941 3076 4315245
SGTC_2921 7974240 10.71 µM -0.297551079956653 0.396987594571862 no 2047 0.383022908315972 3057 2979074 YDR527W RBA50
SGTC_413 propylparaben 100 µM -0.298339966762339 0.396686689641777 no 2048 0.382721851645587 2913 7175 A pharmaceutical preservative.
SGTC_1777 st045864 34.765 µM -0.303303899127758 0.394794716075373 no 2049 0.38082913749474 3005 4691462
SGTC_1001 4048-4355 44.4 µM -0.304778464002571 0.394233169803049 no 2050 0.380267442443229 2932 21824233
SGTC_2378 9074213 121.43 µM -0.305678393722866 0.393890564971242 no 2051 0.379924762839395 2944 657714
SGTC_2443 5493264 126.67 µM -0.306086799565125 0.393735111217079 no 2052 0.379769279159999 3102 5340055
SGTC_1166 k206-0078 225 µM -0.306623969933852 0.393530670902488 no 2053 0.379564803294906 2933 5404595
SGTC_1322 1348-1070 12 µM -0.30736101536468 0.393250208412849 no 2054 0.379284299070751 3055 6758089
SGTC_354 2783-3500 4.88 µM -0.308009993359701 0.393003303431033 no 2055 0.379037364087503 2976 6740761
SGTC_293 4049-0273 38.5 µM -0.310351789211668 0.392112721019474 no 2056 0.378146725944431 2990 1380311
SGTC_455 paf C-16 10 µM -0.310776875125034 0.391951121748294 no 2057 0.377985125377329 2942 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3149 9097855 49.47 µM -0.311874455676262 0.391533955363889 no 2058 0.37756796817951 3097 25236625 YMR079W SEC14
SGTC_144 4161-2749 112.381 µM -0.311922199164678 0.39151581193412 no 2059 0.377549825559395 2970 797501 YMR168C CEP3
SGTC_517 1365-0151 113 µM -0.312658741519352 0.391235941816817 no 2060 0.377269972264305 3127 768657
SGTC_2626 ethyl orsellinate 100 µM -0.313134431247643 0.39105521995427 no 2061 0.377089265590175 2937 75653 A natural product.
SGTC_2778 tioconazole 65.09 nM -0.313814024036711 0.390797072990515 no 2062 0.376831146212278 2926 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1262 0737-0114 49.6 µM -0.314256486424505 0.390629027135682 no 2063 0.376663122040249 3124 765919
SGTC_2136 5328288 199.296 µM -0.314652124284162 0.390478782389653 no 2064 0.376512899168524 2981 262395
SGTC_2203 7227154 166.4 µM -0.315269063968593 0.390244530205077 no 2065 0.376278685777438 2977 896304
SGTC_81 0411-0046 9.971 µM -0.315454474235951 0.390174137653309 no 2066 0.376208305999698 2975 12925265
SGTC_925 2064-1272 59.6 µM -0.316363512760352 0.389829065755127 no 2067 0.375863304189464 2978 6815817
SGTC_1097 itavastatin 7.23 µM -0.316375484422984 0.389824521879092 no 2068 0.375858761319119 3002 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2020 4017018 200 µM -0.317206627730004 0.389509096094564 no 2069 0.375543410608805 3079 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2445 5742597 35.57 µM -0.318373227053693 0.389066484768654 no 2070 0.375100922128265 2969 1774255
SGTC_1094 duloxetine 25.4 µM -0.31922863124776 0.38874203323851 no 2071 0.374776573638967 2944 60834 A selective serotonin reuptake inhibitor.
SGTC_2176 5809774 33.9695 µM -0.323320322148835 0.387191147494081 no 2072 0.373226332481342 3096 2870539
SGTC_2077 5212015 200 µM -0.3237090613531 0.387043895711665 no 2073 0.373079154990961 2924 780900
SGTC_2873 9040596 71.43 µM -0.3242315418557 0.386846009238557 no 2074 0.372881371936392 3090 6463863
SGTC_2238 6671620 73.2395 µM -0.325382339124169 0.386410255221292 no 2075 0.372445860132035 2907 729941
SGTC_593 1203-0218 61.7 µM -0.326016337134915 0.386170250469008 no 2076 0.372205997297017 3121 3666956
SGTC_2082 5219693 150 µM -0.326237103185203 0.386086688025793 no 2077 0.372122485684771 2967 2834649
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.326240614372137 0.386085359044566 no 2078 0.372121157517887 3104 5024745
SGTC_1926 methyl fluorone black 53.6 µM -0.327394464719162 0.385648700166219 no 2079 0.371684776253047 3002 72721 Reacts with homocysteine.
SGTC_2675 theaflavin digallate 100 µM -0.328208118238047 0.385340871192296 no 2080 0.371377155032804 3024 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1560 lithocholic acid 53.1 µM -0.329308690638873 0.384924607344001 no 2081 0.370961187976575 3052 9903 A bile acid which acts as a detergent.
SGTC_1996 st072960 66.8 µM -0.329428056485209 0.384879468174797 no 2082 0.37091608208735 3115 1719405
SGTC_8 0354-0001 70 µM -0.329528774518593 0.384841382041926 no 2083 0.37087802420132 3017 4993152
SGTC_2383 9036125 200 µM -0.331913633933249 0.383939882145881 no 2084 0.369977237535912 2990 79580
SGTC_1145 3546-0597 10.2 µM -0.3329155754166 0.383561325543233 no 2085 0.369599005985624 3034 875334
SGTC_2034 5197015 53.07 µM -0.333096171504467 0.383493103984672 no 2086 0.36953084461518 3142 780676
SGTC_1026 k007-1105 30.6 µM -0.33442598234325 0.382990869079312 no 2087 0.369029067936408 2978 7066794
SGTC_3137 9097352 49.47 µM -0.335316621414905 0.382654607806884 no 2088 0.368693128361864 3302 44120435
SGTC_1429 4049-0205 9.46 µM -0.335346165564039 0.382643454911295 no 2089 0.368681986341041 3030 22774478
SGTC_2924 9010168 62.78 µM -0.33536550794117 0.382636153230203 no 2090 0.36867469178667 3084 2993929
SGTC_800 3448-7362 155 µM -0.335390856083326 0.382626584456552 no 2091 0.368665132361048 3073 15991913
SGTC_178 4092-0806 87.505 µM -0.336579610411064 0.382177917301805 no 2092 0.368216914401696 3078 2169044
SGTC_1827 berberine 7.24 µM -0.337731700113103 0.3817432392481 no 2093 0.367782691867446 2995 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2099 5377090 177.372 µM -0.338304254060147 0.381527272738378 no 2094 0.367566959124609 3090 2243829
SGTC_143 4032-1194 15.74 µM -0.338768260882921 0.381352277095682 no 2095 0.367392156528252 2935 1806963
SGTC_2681 menadione 3.18 µM -0.339016423155437 0.381258695070195 no 2096 0.36729867907069 3083 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2991 9074669 71.4286 µM -0.340722202296287 0.380615633677045 no 2097 0.366656361368738 3194 17333109
SGTC_1071 trifluoperazine 6.31 µM -0.341526565797294 0.380312511100807 no 2098 0.366353604580846 3158 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_93 0109-0045 59.227 µM -0.343223964978984 0.379673091398303 no 2099 0.365714988529559 3035 88733
SGTC_294 k038-0071 157 µM -0.343266179129363 0.379657193277688 no 2100 0.365699110944675 3065 24152826
SGTC_232 clozapine 119 µM -0.34554671426101 0.378798632088367 no 2101 0.364841698750094 3013 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2612 dictamnine 15.46 µM -0.346440414735818 0.378462340268202 no 2102 0.36450587840027 3091 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1620 st003704 16.5 µM -0.346914540642751 0.378283968102807 no 2103 0.36432776120489 3135 2834414
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.347025910265967 0.378242073201631 no 2104 0.364285926681968 3027 2724 A muscle relaxant with antifungal properties.
SGTC_668 1682-0499 62.6 µM -0.347881451955686 0.377920284249127 no 2105 0.363964607735263 3053 682214
SGTC_315 k915-0449 187 µM -0.347887220529648 0.377918114842662 no 2106 0.363962441534974 3058 20970215 YNL149C PGA2
SGTC_2050 5263056 171 µM -0.348019540128665 0.377868354035672 no 2107 0.363912754407769 3164 763468 YGL055W OLE1
SGTC_351 caspofungin 25 nM -0.348499838681523 0.377687747459737 no 2108 0.36373241747527 3048 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2988 9073640 71.4286 µM -0.348938466785237 0.377522833572196 no 2109 0.363567752847596 3222 9102229
SGTC_989 1501-0895 10.3 µM -0.350508758782175 0.37693262382029 no 2110 0.362978459006653 3137 2830112
SGTC_3205 9113483 49.47 µM -0.350839763677194 0.376808248999591 no 2111 0.362854281951924 3186 17018033
SGTC_2295 7971645 200 µM -0.351264132455606 0.376648811478139 no 2112 0.362695100372002 3048 2978226 YKL099C UTP11
SGTC_2784 7567673 72.73 µM -0.351678891788677 0.376493004602892 no 2113 0.362539546241013 3057 3471247
SGTC_2544 sphondin 68.51 µM -0.352822831959387 0.376063380836703 no 2114 0.362110632874175 3211 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_824 1304-0008 100 µM -0.352918098764879 0.376027608888412 no 2115 0.362074920968773 3039 768245
SGTC_1345 1488-0192 31.4 µM -0.353060172753908 0.375974263183779 no 2116 0.362021665059405 3177 658348
SGTC_2874 9043904 71.43 µM -0.354973162052342 0.375256208328579 no 2117 0.361304848611049 3078 4463428
SGTC_806 3966-4455 5.86 µM -0.355404808282256 0.375094246336349 no 2118 0.361143173603676 3044 714982
SGTC_854 0422-0053 192 µM -0.357647000481365 0.374253287451299 no 2119 0.360303750184602 3066 3596728
SGTC_1306 1185-0270 9.02 µM -0.360951686027441 0.373014919809408 no 2120 0.359067782287678 3142 1548076
SGTC_2461 5755302 26.15 µM -0.361304762333012 0.372882688511732 no 2121 0.358935817007136 3177 2788904
SGTC_2862 9027634 71.43 µM -0.361627018630187 0.37276201274722 no 2122 0.35881538566076 3007 5012562
SGTC_1343 1487-0095 224 µM -0.364494982737229 0.371688593547696 no 2123 0.357744209852007 3188 4560101 YGL055W OLE1
SGTC_3180 9109287 49.47 µM -0.366611329149198 0.370897127861062 no 2124 0.356954478173317 3162 18891271
SGTC_2482 5981709 142.65 µM -0.369341178523973 0.369877032486865 no 2125 0.355936717932826 3077 877755
SGTC_1618 st003135 44.5 µM -0.370178735718563 0.369564235583766 no 2126 0.355624659709997 3141 1270615
SGTC_1843 st055809 45.5 µM -0.372510981541443 0.368693682633765 no 2127 0.354756218645688 3201 16413835
SGTC_1051 3253-3903 78 µM -0.372711190416431 0.368618982370914 no 2128 0.354681703444217 3005 5509239
SGTC_1575 cyproterone acetate 48 µM -0.372922450533057 0.368540164144068 no 2129 0.354603081139923 3093 9880 An androgen receptor antagonist and liver toxin.
SGTC_2001 4023502 57.655 µM -0.373279364819972 0.368407016927508 no 2130 0.354470266432597 3164 108941 YCR052W RSC6
SGTC_2276 7947513 42.08 µM -0.373841151053787 0.368197474048209 no 2131 0.354261250760976 3134 2105100
SGTC_2944 9067346 25.62 µM -0.376711077643968 0.367127621634625 no 2132 0.35319416478961 3218 6473075
SGTC_423 5-fluorouracil 457 µM -0.377197993717199 0.366946210923877 no 2133 0.353013235575711 2983 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_102 gallobenzophenone 83.616 µM -0.377357602990756 0.36688675163231 no 2134 0.352953934883105 3246 70837
SGTC_2964 9083345 53.42 µM -0.380248810782932 0.365810243234233 no 2135 0.351880364854961 3120 17741579
SGTC_3269 9137823 49.47 µM -0.38055540505658 0.365696148106424 no 2136 0.351766588596944 3040 17682936
SGTC_534 k292-0788 63.4 µM -0.381286656980079 0.365424070053167 no 2137 0.351495276702589 3243 4146317
SGTC_550 4123-0385 25.7 µM -0.381745838024844 0.365253256437199 no 2138 0.351324948240799 3074 5731123
SGTC_1917 st066507 28.5 µM -0.382423250297381 0.365001310436937 no 2139 0.351073723678827 3055 3156428
SGTC_2648 atorvastatin 78.68 µM -0.386032974722088 0.363659751614672 no 2140 0.349736123876469 3176 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_820 1582-0060 59.9 µM -0.386123991459939 0.36362594664123 no 2141 0.349702421222368 3103 3848840
SGTC_548 1436-0017 110 µM -0.387222464301239 0.363218041251539 no 2142 0.349295760391133 3225 9677137
SGTC_1810 st050138 53 µM -0.388012870613924 0.362924628772292 no 2143 0.349003254487534 3220 3444541
SGTC_1495 4469-0029 237 µM -0.391100060877514 0.361779382592795 no 2144 0.347861637819826 3105 793680
SGTC_796 1234-0020 70.7 µM -0.391102550949146 0.361778459355869 no 2145 0.347860717567308 3082 46495034
SGTC_1546 5-methoxyflavanone 78.7 µM -0.391843697271586 0.361503702374308 no 2146 0.347586852942035 3163 147795
SGTC_2063 5246145 200 µM -0.39297949893386 0.361082777779983 no 2147 0.347167311638037 3204 711240
SGTC_2908 7930301 100 µM -0.393731392076936 0.360804220972606 no 2148 0.346889681049863 3090 2223178
SGTC_2312 7706453 155.7 µM -0.395632932826372 0.360100079440151 no 2149 0.346187919206346 3116 976098
SGTC_125 0133-0007 11.75 µM -0.395718525275712 0.360068395651341 no 2150 0.346156343788681 3247 26541
SGTC_2214 7179297 48.276 µM -0.395852618037321 0.360018760416597 no 2151 0.346106878550294 3122 769744
SGTC_1404 3909-7820 48.3 µM -0.397731922435359 0.359323373360389 no 2152 0.34541390191989 3205 23741373
SGTC_968 1309-0633 340 µM -0.398104799577334 0.359185455297588 no 2153 0.345276468313454 3215 3761976
SGTC_1416 3966-0321 25.3 µM -0.398265139846998 0.359126155024735 no 2154 0.345217376991719 3142 582530 YLR208W SEC13
SGTC_1400 3771-8998 51.5 µM -0.398326216290256 0.359103567395045 no 2155 0.345194869054982 3096 670767
SGTC_1060 3448-7350 82 µM -0.398360406499722 0.359090923196786 no 2156 0.34518226949237 3213 570178
SGTC_1501 4491-0275 38.4 µM -0.399081011493558 0.358824465514649 no 2157 0.344916756579617 3213 5104718
SGTC_2067 5224629 34.075 µM -0.40008886716621 0.358451906555944 no 2158 0.344545531847617 3244 2835000
SGTC_2682 pyrogallin 40.03 µM -0.400695276071784 0.358227809304721 no 2159 0.344322244595502 3141 822798 An ATP competetive kinase inhibitor.
SGTC_1927 st060202 13.8 µM -0.400726310010042 0.358216342084933 no 2160 0.344310818974555 3244 688887
SGTC_2310 7668677 200 µM -0.40282410880433 0.357441490279668 no 2161 0.343538812038618 3327 2197143
SGTC_531 3788-1495 174 µM -0.403215970888809 0.357296815456671 no 2162 0.343394675816729 3053 2896655
SGTC_3340 9146634 11.102 µM -0.403691978324933 0.357121101902527 no 2163 0.343219619561574 3202 4907387
SGTC_420 mitomycin C 81.9 mM -0.404523041439614 0.35681439561509 no 2164 0.342914068854575 3109 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_942 3253-1115 227 µM -0.404908854726674 0.356672041525928 no 2165 0.342772254689699 3302 46497897
SGTC_560 2332-1943 155 µM -0.405036266589446 0.356625034569299 no 2166 0.342725426520305 3141 21177716
SGTC_1189 1431-2119 7.28 µM -0.406312170497187 0.356154426540813 no 2167 0.34225662204806 3178 3107275
SGTC_458 nppb 133 µM -0.40643627966722 0.356108661439053 no 2168 0.342211033659711 3303 4549 A chloride channel blocker.
SGTC_1932 st074806 40.9 µM -0.406608920932148 0.356045003635149 no 2169 0.342147622048809 3351 17251235
SGTC_706 4262-0057 46.9 µM -0.406630942597501 0.356036883901763 no 2170 0.342139533750695 3102 883298
SGTC_1203 3992-3522 103 µM -0.406699010726922 0.356011786527744 no 2171 0.342114533587019 3413 5322312
SGTC_392 N-ethylmaleimide 8.33 µM -0.40767017427331 0.355653777186681 no 2172 0.341757918621134 3124 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2911 7942208 15.64 µM -0.408221020782574 0.355450769906218 no 2173 0.341555708400238 3197 1243384
SGTC_1394 3474-0001 65.7 µM -0.410134360713417 0.35474595237746 no 2174 0.340853694084007 3162 5017666 YIL048W NEO1
SGTC_2073 5212005 126 µM -0.410145139401722 0.354741983234636 no 2175 0.340849740885345 3144 691789
SGTC_2097 5376186 200 µM -0.41080351954439 0.354499571326961 no 2176 0.340608306110508 3223 742755
SGTC_2642 cholecalciferol 100 µM -0.411279883822328 0.354324213382943 no 2177 0.340433659132144 3209 9821465 A vitamin D precursor, similar to steriods.
SGTC_3202 9113761 49.47 µM -0.411546435676267 0.354226104498929 no 2178 0.3403359495268 3248 4798415
SGTC_2946 9065502 71.43 µM -0.411711110213186 0.354165498105739 no 2179 0.34027559032771 3138 16489101
SGTC_1454 4239-0054 42.6 µM -0.411774884475757 0.354142027782294 no 2180 0.340252215843251 3306 1340767
SGTC_1135 dihydrocapsaicin 536.708 nM -0.412989934757993 0.353694968638988 no 2181 0.339806994068016 3077 107982 A Capsaicinoid.
SGTC_327 1273-0057 3.96 µM -0.413398610097279 0.353544648104725 no 2182 0.339657296393503 3146 3108138
SGTC_1603 st002045 67.8 µM -0.415496210313985 0.352773460610703 no 2183 0.338889344414876 3254 5887985
SGTC_2909 7941780 10.49 µM -0.415797956470743 0.352662572615218 no 2184 0.338778927168582 3285 1243215
SGTC_850 0388-0143 75.9 µM -0.416008411499306 0.352585240393964 no 2185 0.338701924065153 3134 67273
SGTC_1193 1488-0126 41.5 µM -0.416936054153136 0.352244448448212 no 2186 0.338362590543258 3145 1384710
SGTC_1885 st057546 99.9 µM -0.417074248099453 0.352193689707047 no 2187 0.338312050147896 3301 702008
SGTC_2737 bleomycin 30.5 nM -0.417186972970695 0.352152287726234 no 2188 0.338270826479158 3199 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1863 st057641 20.1 µM -0.418213975999895 0.351775167263762 no 2189 0.337895339142455 3209 3921635
SGTC_1998 st075797 76.8 µM -0.419276229472897 0.351385256050823 no 2190 0.337507133367851 3251 24208315
SGTC_1718 roemerine 11.9335 µM -0.41991212846713 0.351151917476592 no 2191 0.337274823631431 3225 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1271 0832-2808 169 µM -0.420201564172034 0.351045729695578 no 2192 0.337169106096864 3263 3663794
SGTC_888 0916-0002 6.97 µM -0.420256170781767 0.351025697000139 no 2193 0.337149162258355 3288 2802138 YIL048W NEO1
SGTC_745 0469-0705 296 µM -0.420918012914387 0.350782929988442 no 2194 0.336907475679515 3370 3486736
SGTC_7 0192-1582 4.227 µM -0.421789393714136 0.350463396044968 no 2195 0.336589374009481 3177 252616
SGTC_682 0kpi-0099 17 µM -0.422268100906976 0.35028789989143 no 2196 0.336414669426674 3244 1714895 YML126C ERG13
SGTC_1464 k208-0027 110 µM -0.423338928989536 0.349895445381622 no 2197 0.336023997729344 3327 X1464
SGTC_3224 9130643 49.47 µM -0.424021644835864 0.349645316216325 no 2198 0.335775013964349 3323 17644395
SGTC_729 4092-0585 94.1 µM -0.424902036256627 0.349322860253071 no 2199 0.335454045101428 3123 2169061
SGTC_1261 0712-0010 12.7 µM -0.425391287035717 0.349143712133493 no 2200 0.33527572828864 3317 2840123
SGTC_287 k060-0039 29.6 µM -0.426213530655389 0.348842708324745 no 2201 0.334976129465514 3282 5861974
SGTC_1465 k213-0056 144 µM -0.427786267226921 0.348267231984987 no 2202 0.334403367996339 3120 24048857 YMR208W ERG12
SGTC_1331 1472-0049 76.2 µM -0.427869852399336 0.348236657291054 no 2203 0.334372938598264 3114 24051409
SGTC_488 nitrendipine 139 µM -0.427922268125699 0.348217484599442 no 2204 0.334353857072772 3204 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_809 3998-0021 90 µM -0.43032898590981 0.347337570787965 no 2205 0.333478172411038 3283 715485
SGTC_2463 5473429 200 µM -0.431618193300967 0.34686656486885 no 2206 0.333009466659553 3197 5399405
SGTC_218 alverine citrate 93.75 µM -0.432607141722624 0.34650541743821 no 2207 0.332650100096991 3291 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1371 2421-0008 32.7 µM -0.433340488235232 0.346237701592754 no 2208 0.332383714037352 3154 2827552
SGTC_924 2046-0044 21.3 µM -0.433984188275695 0.346002775429892 no 2209 0.332149961556149 3184 3623589
SGTC_927 2425-1185 123 µM -0.434710358767944 0.345737821811077 no 2210 0.331886339229761 3115 730375
SGTC_1663 st014140 55.4 µM -0.435410430936629 0.34548246204455 no 2211 0.331632270173653 3240 4207120
SGTC_2871 9038510 12.99 µM -0.436289527529574 0.345161900543155 no 2212 0.331313339543199 3353 4945164
SGTC_3117 9124945 49.47 µM -0.436630463424423 0.345037608562143 no 2213 0.331189683079468 3116 17592065
SGTC_1967 st070177 51.4 µM -0.437356154613263 0.34477310542391 no 2214 0.330926538283 3321 5729214
SGTC_365 0121-0052 13.6 µM -0.438038009815278 0.344524648935228 no 2215 0.330679365058451 3281 3101739
SGTC_3027 9089541 49.47 µM -0.438353063912112 0.344409871202867 no 2216 0.330565182545468 3260 9943819
SGTC_1251 0490-5699 265 µM -0.43957899800497 0.343963386114254 no 2217 0.330121027285794 3345 3883818
SGTC_2351 9026858 72.31 µM -0.439677006069416 0.343927700966305 no 2218 0.330085529339571 3107 1409300
SGTC_1035 k081-0041 55.2 µM -0.439879280836318 0.343854056269669 no 2219 0.330012271441688 3323 731709
SGTC_2685 mycophenolic acid 18.85 µM -0.440411839636135 0.343660189283897 no 2220 0.329819425678712 3189 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3242 9133940 49.47 µM -0.4438795688437 0.342398841754467 no 2221 0.328564828403915 3304 17248444
SGTC_2799 7812892 81.82 µM -0.444597497587014 0.342137922166961 no 2222 0.328305328110528 3310 20205235
SGTC_3195 9113082 49.47 µM -0.444776805984672 0.342072767186206 no 2223 0.328240528774972 3278 17018038
SGTC_1313 1220-0047 237 µM -0.444803276070236 0.342063149195487 no 2224 0.328230963325193 3243 3528706
SGTC_276 colchicine 750 µM -0.445004891382402 0.341989894986586 no 2225 0.328158109639075 3324 2833 A microtubule depolymerizer.
SGTC_2977 9011197 71.43 µM -0.446997923752806 0.341266073886943 no 2226 0.327438279498317 3344 2704722
SGTC_3017 9080681 49.47 µM -0.447750093243636 0.340993055681905 no 2227 0.327166782419065 3257 16451914
SGTC_1312 1218-2183 165 µM -0.44781091523088 0.340970982498662 no 2228 0.327144832594817 3296 6744073
SGTC_193 1273-0060 1.558 µM -0.447968804643228 0.340913684676716 no 2229 0.327087855253459 3252 2847393 YHR072W ERG7
SGTC_2549 cedrol 20.94 µM -0.452326841101296 0.339333612501073 no 2230 0.325516771127971 3305 6708665 A sedative which affects the nervous system.
SGTC_2624 nerol 100 µM -0.452335373330121 0.33933052177008 no 2231 0.325513698262909 3216 637566 A natural product oil.
SGTC_1191 1487-1166 10.6 µM -0.453509997885465 0.338905126764122 no 2232 0.32509077286903 3289 3955771
SGTC_574 1315-0397 40 µM -0.454108360666149 0.338688506189331 no 2233 0.324875417983863 3232 6794277
SGTC_2876 9059903 25.97 µM -0.454696790126357 0.338475533722035 no 2234 0.324663695228541 3292 6916095
SGTC_1417 3966-0327 90.4 µM -0.459768779851947 0.336641957158615 no 2235 0.322841097329063 3272 651118
SGTC_1156 4092-0367 4.88 µM -0.459961099993345 0.336572507466901 no 2236 0.322772071209962 3239 1357585
SGTC_1180 1193-0155 285 µM -0.460208302181077 0.336483247231368 no 2237 0.322683356201985 3315 2921347
SGTC_710 3448-4187 58 µM -0.461587491822184 0.335985416043459 no 2238 0.322188583060381 3292 3946412
SGTC_2056 5235370 200 µM -0.461749141839652 0.335927085795433 no 2239 0.322130613024125 3190 5511916
SGTC_1272 0839-0021 27 µM -0.463657611428662 0.335238727307788 no 2240 0.321446535618244 3286 5027250
SGTC_1045 1348-1485 165 µM -0.46517880590328 0.334690449404506 no 2241 0.320901707481941 3236 6810614
SGTC_2047 4141938 200 µM -0.466224732822178 0.334313674533 no 2242 0.320527323808242 3226 3807862
SGTC_2722 naftopidil 47.16 µM -0.468779065364885 0.333394227773421 no 2243 0.319613782609846 3325 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2194 5927483 104.545 µM -0.469479938407817 0.333142119089819 no 2244 0.319363310652339 3225 760979
SGTC_1042 0350-0096 82 µM -0.469988142036034 0.332959362012359 no 2245 0.319181744759394 3217 3122515
SGTC_2188 6126565 140.678 µM -0.470117708079029 0.332912774609874 no 2246 0.319135461638934 3318 874518
SGTC_366 0181-0206 4.31 µM -0.471407706916783 0.332449077067593 no 2247 0.31867480670522 3424 274874
SGTC_2596 sinensetin 100 µM -0.47368610778155 0.331630719129215 no 2248 0.317861880684695 3233 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2337 9009472 200 µM -0.473728600532026 0.331615464162984 no 2249 0.317846727728786 3421 5742383
SGTC_1697 st025554 27.742 µM -0.475514255050234 0.330974664018754 no 2250 0.317210237594535 3217 1269519
SGTC_2353 9059630 146.67 µM -0.476382546305217 0.33066324763069 no 2251 0.31690093341019 3315 4779114
SGTC_1092 toremifene 6.32 µM -0.476688598394839 0.330553508654524 no 2252 0.316791941495436 3280 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2244 6635614 200 µM -0.476839061158272 0.330499563604754 no 2253 0.316738364208563 3091 836499
SGTC_2782 7736369 71.43 µM -0.479634671404067 0.329497901830242 no 2254 0.315743594101721 3261 2950836 YOL077C BRX1
SGTC_2105 5350118 200 µM -0.480866483827847 0.329056933247987 no 2255 0.315305697423279 3288 2133313
SGTC_3225 9130819 49.47 µM -0.481088849519833 0.328977355306511 no 2256 0.31522667631619 3348 4547121
SGTC_2541 muurolladie-3-one 83.07 µM -0.481524564619041 0.328821448554495 no 2257 0.315071862691023 3405 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1270 0831-1170 17.3 µM -0.481575583993212 0.328803194845968 no 2258 0.315053737156776 3337 6764716
SGTC_1630 st005209 31.3 µM -0.482079885065514 0.328622788013656 no 2259 0.314874599251246 3372 3367314
SGTC_1286 0929-0070 131 µM -0.483318354055014 0.32817991215759 no 2260 0.314434854957402 3358 1420408
SGTC_265 mycophenolic acid 32.932 µM -0.485835164226494 0.327280646448168 no 2261 0.313542020200743 3478 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_323 4013-0906 34.3 µM -0.485871103766521 0.327267812356784 no 2262 0.313529278592017 3331 2910086
SGTC_2766 oltipraz 83.91 µM -0.48619789706715 0.327151123098438 no 2263 0.313413431105056 3357 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3218 9131285 49.47 µM -0.487272808089951 0.326767419977255 no 2264 0.313032507460908 3430 17156417
SGTC_2935 9038016 29.96 µM -0.487629854982745 0.326640008058433 no 2265 0.312906022402232 3398 6463195
SGTC_107 0358-0022 2.6945 µM -0.488441107772205 0.32635058827403 no 2266 0.312618715256745 3315 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2027 5150920 200 µM -0.488916243924438 0.326181128840769 no 2267 0.312450497479214 3277 786715
SGTC_3291 9121177 71.43 µM -0.493312545115049 0.324614874224839 no 2268 0.310895882784217 3276 17015612
SGTC_3107 9121808 49.47 µM -0.494348622886405 0.324246204325455 no 2269 0.310529995763564 3343 662681
SGTC_2768 sulfasalazine 50.2 µM -0.494573270910119 0.324166290020791 no 2270 0.310450686852847 3430 5384001 An antioxidant and salicylic acid derivative.
SGTC_2520 obtusaquinone 4.71 µM -0.49524404557984 0.323927722776973 no 2271 0.310213931478915 3425 5967872
SGTC_542 3381-0244 89.3 µM -0.496073519260764 0.323632812749321 no 2272 0.309921270751509 3414 1112843
SGTC_1489 4065-0444 182 µM -0.497864666589754 0.322996368368669 no 2273 0.309289716475476 3362 2877968
SGTC_1419 3993-2473 62.6 µM -0.50014403785115 0.322187193493116 no 2274 0.308486829819053 3339 704026
SGTC_167 3672-0051 66.205 µM -0.500246970684453 0.322150672267064 no 2275 0.308450594280441 3276 3237971
SGTC_3144 9087057 49.47 µM -0.500553934753771 0.32204176965365 no 2276 0.30834254452063 3362 17249618
SGTC_2025 5147754 141 µM -0.500908941410077 0.32191584187325 no 2277 0.30821760472132 3313 315777 YLR208W SEC13
SGTC_2252 omeprazole 400 µM -0.501069235951603 0.321858988975158 no 2278 0.308161198501105 3220 4594 A proton pump inhibitor.
SGTC_3278 9139605 49.47 µM -0.502140997237489 0.321478966360366 no 2279 0.307784171720793 3425 7958859
SGTC_1780 st038448 24.544 µM -0.503506119205317 0.320995195072162 no 2280 0.307304239589495 3412 728868 YDL195W SEC31
SGTC_1671 st016596 74.5 µM -0.504907175544197 0.320499005155724 no 2281 0.30681201701911 3389 2829167
SGTC_3166 9102297 49.47 µM -0.505440075214987 0.320310360652392 no 2282 0.306624888727386 3326 25237072
SGTC_3249 9135183 49.47 µM -0.505775849807543 0.320191521533443 no 2283 0.306507006997024 3415 4902779
SGTC_15 0266-0086 27.098 µM -0.506197106725493 0.320042454140905 no 2284 0.306359142956394 3417 1712902 YIL048W NEO1
SGTC_882 0843-0131 351 µM -0.506304209079603 0.320004559171498 no 2285 0.306321554328319 3412 5425421
SGTC_1706 st031321 9.9705 µM -0.506995677117394 0.319759949071605 no 2286 0.306078925869298 3381 6103185
SGTC_1665 st014639 11.4 µM -0.507058283656935 0.319737805578662 no 2287 0.306056962126803 3402 981133 YIL048W NEO1
SGTC_2137 5261020 140 µM -0.508395875485155 0.319264862359113 no 2288 0.305587872359877 3300 763655
SGTC_58 0957-0393 9 µM -0.508730438513972 0.319146614115312 no 2289 0.305470591858897 3399 6997992
SGTC_738 1315-0003 72.4 µM -0.50875569525102 0.319137688099266 no 2290 0.305461738962813 3410 6251474
SGTC_2390 9097792 176.6 µM -0.509457439585337 0.318889725673275 no 2291 0.305215811692112 3311 4497149
SGTC_3212 9128307 49.47 µM -0.509551343092596 0.318856550872019 no 2292 0.305182909744938 3163 27243542
SGTC_109 0132-0036 33.701 µM -0.509591650848565 0.318842311148412 no 2293 0.305168787180716 3310 67274 A color developer.
SGTC_14 0354-0009 295 µM -0.512159420534285 0.317935734160277 no 2294 0.304269720384911 3322 1713507
SGTC_2387 9077560 195.08 µM -0.512321174616557 0.317878661691218 no 2295 0.304213124086952 3283 5303272
SGTC_2132 5317594 122.667 µM -0.51353405733721 0.317450852366879 no 2296 0.303788896840226 3276 794577
SGTC_2124 5246320 200 µM -0.513988822779435 0.317290509791979 no 2297 0.303629902623902 3371 579342
SGTC_1554 st069299 38.7 µM -0.514996828575476 0.316935226315858 no 2298 0.3032776180842 3362 24207999
SGTC_2327 6189656 200 µM -0.515306914460123 0.316825966826767 no 2299 0.303169283976152 3377 5349088
SGTC_3020 9089140 49.47 µM -0.517884604614468 0.315918330724676 no 2300 0.302269392060555 3411 17217859
SGTC_1762 st045503 25.4615 µM -0.518340088655724 0.315758064349656 no 2301 0.302110503681204 3365 4645554
SGTC_2763 lisinopril 49.32 µM -0.518782619002659 0.315602389024879 no 2302 0.301956169915844 3423 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_577 r071-0003 38.6 µM -0.519296368437952 0.315421700965055 no 2303 0.301777042723122 3333 4568517 YMR134W ERG29
SGTC_1088 bifonazole 369 nM -0.520724660413544 0.314919596040312 no 2304 0.301279296415927 3362 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2841 9004761 38.96 µM -0.52149161133354 0.314650121429064 no 2305 0.301012173900068 3301 2991039
SGTC_1079 idarubicin 2.36 µM -0.522226127919097 0.314392135403962 no 2306 0.300756448123099 3393 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3125 9127534 49.47 µM -0.522608037261908 0.31425803226916 no 2307 0.300623523142127 3340 1639235
SGTC_490 phenamil 164 µM -0.523128952501741 0.314075158312984 no 2308 0.300442259407491 3339 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1677 st019204 53.9 µM -0.523754121521481 0.313855744995683 no 2309 0.300224783520842 3358 3945625
SGTC_1847 st056231 15 µM -0.526254594923916 0.312978821442282 no 2310 0.299355662965976 3363 5393180
SGTC_1196 1588-0294 184 µM -0.526512976682417 0.312888266354304 no 2311 0.29926591909858 3367 6144269
SGTC_1466 k213-0079 57.5 µM -0.527529725476326 0.312532035928533 no 2312 0.298912889803635 3384 3657981
SGTC_661 1304-0007 33.6 µM -0.528676737131742 0.312130376481576 no 2313 0.298514858683095 3346 3117130
SGTC_2794 7785382 27.27 µM -0.528961202874164 0.312030797066257 no 2314 0.298416181914395 3436 2205081
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.530736242161139 0.311409741421832 no 2315 0.297800783815808 3388 16486 A toxic proline analog.
SGTC_3288 9119690 36.221 µM -0.532046153720591 0.310951769738515 no 2316 0.297347014926104 3347 17595618 YKL019W RAM2
SGTC_831 k061-1017 217 µM -0.532247641957802 0.310881351309915 no 2317 0.297277245052336 3398 1240153
SGTC_3038 9091290 49.47 µM -0.532892098916494 0.310656165582069 no 2318 0.297054137454049 3443 25236843
SGTC_453 enantio-paf c16 10 µM -0.534645143674086 0.310043976854434 no 2319 0.296447630422916 3419 13871343 A lipid and platelet activating factor
SGTC_1162 k048-0130 20.1 µM -0.536483893096313 0.309402424175129 no 2320 0.295812082404809 3345 6797406
SGTC_3265 9137266 49.47 µM -0.536725274013098 0.309318247730596 no 2321 0.295728697651484 3373 17224265
SGTC_338 4055-0136 114 µM -0.5370544571614 0.309203468259627 no 2322 0.295614999132236 3357 2900563
SGTC_1834 st055981 52.8 µM -0.537300594137723 0.309117657465384 no 2323 0.295529997554897 3477 471719 YDL150W RPC53
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.537973125190102 0.308883245909018 no 2324 0.295297801276417 3354 4330530
SGTC_990 3985-0011 41.3 µM -0.538292999940158 0.308771780461171 no 2325 0.295187391643983 3346 5399565 YGL099W LSG1
SGTC_2260 7964312 200 µM -0.538552222418604 0.308681463182564 no 2326 0.29509793100919 3462 231951
SGTC_2290 7904846 200 µM -0.539580152754352 0.30832342969445 no 2327 0.294743303511886 3393 2962154
SGTC_848 0368-0089 85.6 µM -0.539811110933409 0.308243010820707 no 2328 0.294663651887612 3422 762535
SGTC_2250 alverine citrate 130 µM -0.539865712251477 0.308224000167312 no 2329 0.294644822727569 3382 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_332 4112-0506 40.9 µM -0.54021397648491 0.308102756397443 no 2330 0.294524737534925 3389 2790355
SGTC_2324 6149169 200 µM -0.541876084003785 0.30752440337577 no 2331 0.293951936633826 3331 2888231
SGTC_2884 9058502 51.95 µM -0.542853830137645 0.30718440650697 no 2332 0.293615223401696 3443 6471554
SGTC_2198 6589944 200 µM -0.543798140359952 0.306856193754968 no 2333 0.293290194334788 3406 5290268
SGTC_44 0929-0055 61.211 µM -0.545804852096291 0.306159237509789 no 2334 0.29260004381183 3309 1379590
SGTC_1294 1000-1494 117 µM -0.545986796585073 0.30609608052218 no 2335 0.29253750658716 3381 712797 YDL207W GLE1
SGTC_2106 5357045 167.29 µM -0.546263893825447 0.305999904966341 no 2336 0.29244227577838 3396 668842
SGTC_511 blebbistatin 171 µM -0.547587964178566 0.305540528255033 no 2337 0.291987427776393 3497 3476986 A myosin inhibitor.
SGTC_2919 7978188 46.38 µM -0.548041553942107 0.305383228861892 no 2338 0.291831685254859 3485 2980291
SGTC_2473 5854593 8.94 µM -0.548126269997728 0.305353854348623 no 2339 0.291802601824118 3347 2872951
SGTC_2929 9013348 24.6 µM -0.548333155350024 0.305282124023098 no 2340 0.291731582760489 3394 2995952
SGTC_2094 5332512 191.667 µM -0.5494846220051 0.304883029542746 no 2341 0.291336457549235 3465 755774
SGTC_714 4296-0578 26.1 µM -0.550440814646634 0.304551792679033 no 2342 0.291008530443498 3391 1589775
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.550660024773084 0.304475878166336 no 2343 0.290933376444044 3458 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_509 pifithrin 175 µM -0.551272302015643 0.304263885465807 no 2344 0.290723511376234 3484 4817 A p53 inhibitor.
SGTC_1801 st050089 28.441 µM -0.551763387268239 0.304093901372909 no 2345 0.29055523743793 3444 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_885 0865-0106 16.8 µM -0.551902073280724 0.304045904305506 no 2346 0.290507723919926 3419 2793380
SGTC_697 0508-1955 564 µM -0.552095090371491 0.303979109719508 no 2347 0.29044160274868 3472 6243113
SGTC_3080 9117754 49.47 µM -0.55271893556964 0.303763269544897 no 2348 0.290227942536575 3530 9550191
SGTC_3087 9117406 49.47 µM -0.554346205306598 0.303200583102645 no 2349 0.289670967111721 3441 42546093
SGTC_312 4092-0653 6.84 µM -0.554850709321159 0.303026227573202 no 2350 0.2894983894182 3441 1148278
SGTC_900 1112-0045 141 µM -0.556709090121703 0.302384362419241 no 2351 0.288863102606362 3408 56211 YIL048W NEO1
SGTC_3131 9127911 49.47 µM -0.558342155074359 0.301820822892942 no 2352 0.288305382158407 3535 45595681
SGTC_2275 7947463 200 µM -0.560455344209551 0.301092303151602 no 2353 0.287584445426989 3443 1225414
SGTC_2000 st075254 36.4 µM -0.561540415860084 0.300718534025199 no 2354 0.287214593242799 3430 17234175
SGTC_57 miconazole 162.5 nM -0.561730132041131 0.300653204966023 no 2355 0.287149950648584 3422 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1909 st060837 51.5 µM -0.561769212084142 0.300639748488786 no 2356 0.287136635637556 3366 678937
SGTC_2511 berberine 10.47 µM -0.565534393819111 0.299344556155467 no 2357 0.285855168636873 3428 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1882 5615643 20 µM -0.566362913750646 0.299059892004797 no 2358 0.285573550113274 3426 2253075
SGTC_934 2950-0684 338 µM -0.566815338622112 0.298904499072338 no 2359 0.285419824149469 3501 1121253
SGTC_821 1114-0266 29.2 µM -0.569177183190494 0.298093880063573 no 2360 0.284617951645474 3453 3123235
SGTC_2983 9022671 12.99 µM -0.5694979652402 0.297983860353566 no 2361 0.284509125594285 3500 6405161
SGTC_2811 7967822 32.47 µM -0.570380600548904 0.29768123548783 no 2362 0.284209792149145 3474 2232244
SGTC_1403 3909-7815 62.9 µM -0.570596646304025 0.297607182302714 no 2363 0.284136546192626 3407 6615483
SGTC_2518 prenyletin 46.28 µM -0.571973214588023 0.297135538798694 no 2364 0.283670060612959 3418 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2820 7989630 71.43 µM -0.574187502471423 0.296377591407031 no 2365 0.282920462724237 3401 2984098
SGTC_2993 9054257 71.4286 µM -0.575023817870759 0.296091552693088 no 2366 0.282637594421269 3460 6470217 YGL055W OLE1
SGTC_2694 st077685 81.9 µM -0.575541966798226 0.29591439766708 no 2367 0.282462408299467 3414 2838096
SGTC_3009 9080819 71.4286 µM -0.576988950505744 0.295419932133962 no 2368 0.281973459912301 3449 17027216
SGTC_1989 st071868 50.2 µM -0.579361186084351 0.294610111495491 no 2369 0.281172744032299 3489 16414057
SGTC_3320 9137005 35.139 µM -0.580991789236836 0.294054059829701 no 2370 0.280622993678807 3436 4908713
SGTC_920 mycophenolic acid 780.421 nM -0.581208580723789 0.293980168358163 no 2371 0.280549942611044 3427 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3216 9129716 49.47 µM -0.58360793155883 0.293162944649828 no 2372 0.27974206133331 3424 8056934
SGTC_2409 alverine citrate 63.97 µM -0.583956893323064 0.293044175372266 no 2373 0.279624657111337 3573 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3021 9087658 49.47 µM -0.584522592549599 0.292851686847774 no 2374 0.279434384858826 3497 25237042
SGTC_2715 st079500 56.4 µM -0.584598493482822 0.292825864765433 no 2375 0.279408860456918 3454 28246688
SGTC_1906 st060206 94.7 µM -0.586498179480001 0.292179921532876 no 2376 0.278770392283953 3489 5133468
SGTC_2798 7813637 45.45 µM -0.586586238401423 0.292149995267435 no 2377 0.278740813665901 3502 956368
SGTC_1690 st023502 41.2 µM -0.58716911004574 0.291951946015545 no 2378 0.278545068086203 3512 24207482
SGTC_2708 st078559 56 µM -0.587668390039669 0.291782349425268 no 2379 0.278377448320563 3450 17250902
SGTC_1183 1254-0324 198 µM -0.588758042651588 0.29141237319406 no 2380 0.278011797710459 3524 5799357
SGTC_570 0987-0065 62.6 µM -0.588993180339549 0.291332564216264 no 2381 0.277932924197214 3397 3104428
SGTC_2223 6903751 107.57 µM -0.589462726325226 0.291173224354586 no 2382 0.277775454520612 3474 5598863
SGTC_438 sphingosine 6.67 µM -0.589585615448516 0.291131528798978 no 2383 0.277734248902684 3338 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1743 st037606 46.3785 µM -0.591637435840487 0.290435770521987 no 2384 0.277046699944 3500 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_746 1095-0025 46.6 µM -0.593111232052075 0.289936497134389 no 2385 0.276553357009308 3540 6749286
SGTC_1093 fluphenazine 7.97 µM -0.595468231135276 0.289138861433324 no 2386 0.275765264336129 3512 6602611 An atypical antipsychotic.
SGTC_1760 st045453 10.4495 µM -0.595687060654672 0.289064859373602 no 2387 0.275692151929346 3525 3323419 YIL048W NEO1
SGTC_2115 tiliquinol 12.7705 µM -0.596900804189593 0.288654566872205 no 2388 0.275286805171346 3450 71208 A bioactive hydroxyquinoline.
SGTC_2646 retinol 96.75 µM -0.598410711298122 0.288144542753555 no 2389 0.27478296020528 3536 445354 A vitamin A analog and teratogen.
SGTC_2614 arthonioic acid 13.39 µM -0.598906978216857 0.287977004072424 no 2390 0.27461745888396 3484 6710684
SGTC_262 fenpropimorph 62.5 µM -0.599536580713196 0.28776451778279 no 2391 0.274407561923091 3486 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.599792716285348 0.287678095080496 no 2392 0.27432219407851 3552 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3060 1327-0027 12.5 µM -0.601150638628188 0.287220123516662 no 2393 0.273869829057972 3449 16000455 YPR107C YTH1
SGTC_20 0481-0013 4.944 µM -0.601257431929306 0.287184121153327 no 2394 0.27383426862731 3501 182045
SGTC_2858 9025781 8.96 µM -0.601585819306534 0.287073427954204 no 2395 0.273724935283264 3564 4894980 YPL153C RAD53
SGTC_2174 5790901 200 µM -0.603210723409372 0.286526000928882 no 2396 0.273184257429324 3514 786020
SGTC_1066 ketoconazole 628 nM -0.60353864135628 0.286415586097909 no 2397 0.273075208750691 3562 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_711 k292-0785 179 µM -0.604168021316192 0.286203721132866 no 2398 0.272865969742683 3548 4146315
SGTC_3089 9117425 49.47 µM -0.604384335428961 0.286130921607446 no 2399 0.272794073917934 3473 9401657
SGTC_1101 ebselen 5.29 µM -0.604676142482377 0.286032729217931 no 2400 0.272697101569757 3580 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2493 resveratrol 26.09 µM -0.604787334698311 0.285995317511751 no 2401 0.272660155044371 3479 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_744 1594-0068 283 µM -0.60599737200103 0.285588339090208 no 2402 0.272258249159405 3531 668392
SGTC_676 falcarinol 140 µM -0.606893248717472 0.285287201690578 no 2403 0.271960879413959 3593 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1773 st048542 73.5835 µM -0.610487564467165 0.284080542240975 no 2404 0.270769439292455 3477 3237138
SGTC_2221 6807166 181.081 µM -0.610512753520655 0.284072094562963 no 2405 0.270761098854234 3499 674925
SGTC_659 k018-0002 107 µM -0.611381693244885 0.28378075097679 no 2406 0.270473459643919 3541 6797879 YHR007C ERG11
SGTC_2014 4013930 200 µM -0.611984866709277 0.283578599336472 no 2407 0.270273885051329 3534 64556
SGTC_42 0133-0086 60.653 µM -0.61254246045153 0.283391784986865 no 2408 0.270089457133372 3500 162923 Model of phenazepam hydroxylation.
SGTC_585 0kpi-0023 191 µM -0.61278843331918 0.28330939381575 no 2409 0.27000811995374 3499 64601
SGTC_402 epigallocatechin gallate 10 µM -0.612907628166875 0.283269472393828 no 2410 0.269968709557648 3483 65064 An antioxidant.
SGTC_1616 st002734 56.1 µM -0.612955658773804 0.283253386470202 no 2411 0.269952829607461 3493 4026101
SGTC_3116 9124943 49.47 µM -0.61327872470387 0.283145199892577 no 2412 0.269846029221656 3472 41905195 YPL160W CDC60
SGTC_3068 9116768 49.47 µM -0.614432716182118 0.282758919425176 no 2413 0.269464711069399 3534 41904888
SGTC_845 0330-0138 4.51 µM -0.614758288035276 0.28264998518455 no 2414 0.269357179891471 3519 9039800
SGTC_2519 cryptotanshinone 88.04 µM -0.615370992760779 0.282445032851588 no 2415 0.269154871680099 3550 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2837 9008476 45.46 µM -0.615812025497579 0.282297549781177 no 2416 0.269009294831753 3566 2992805
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.616536910330208 0.282055225993867 no 2417 0.268770109486042 3552 4213774
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.616864960685339 0.281945594051665 no 2418 0.268661900051238 3513 2374 Ca(2+)-ATPase inhibitor.
SGTC_2453 5731132 22.18 µM -0.617353791193127 0.281782268695174 no 2419 0.268500696914389 3583 1362040
SGTC_2802 7925815 54.55 µM -0.618020981142406 0.281559424485471 no 2420 0.268280754141626 3515 1262923
SGTC_1225 1216-0074 20.6 µM -0.618399039726153 0.281433189092186 no 2421 0.268156165328293 3500 4241466
SGTC_497 capsazepine 133 µM -0.618484350351556 0.281404707283135 no 2422 0.268128055327494 3478 2733484 A calcium channel blocker.
SGTC_972 1319-0219 195 µM -0.620911050642322 0.280595112113773 no 2423 0.267329074935992 3509 23903702
SGTC_477 mead ethanolamide 10 µM -0.621838627046632 0.280285952293698 no 2424 0.267023992120085 3445 16061185
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.623388878533702 0.279769624390149 no 2425 0.266514502281092 3590 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1565 sinapyl alcohol 95.1 µM -0.623480754249418 0.279739038687206 no 2426 0.266484322785827 3537 5280507 A phenol propionate derived from cinnamic acid.
SGTC_70 0141-0289 43.283 µM -0.623913293003012 0.279595067034254 no 2427 0.266342264931504 3560 352408
SGTC_1572 epiandrosterone 68.9 µM -0.624753118784975 0.279315631594475 no 2428 0.266066552077314 3535 441302 A steroid.
SGTC_2265 7929201 200 µM -0.624935469146672 0.279254976048764 no 2429 0.266006705983064 3545 1265108
SGTC_2474 5321570 43.32 µM -0.626549935917185 0.278718232315716 no 2430 0.265477147057625 3537 2841384
SGTC_2546 rhodinyl acetate 100 µM -0.627823139908324 0.278295298922553 no 2431 0.265059902808649 3557 6708682
SGTC_1242 0402-0103 60.1 µM -0.628186208066606 0.278174752154236 no 2432 0.264940982081978 3535 432868
SGTC_3235 9132602 49.47 µM -0.630145184885869 0.277524767657011 no 2433 0.264299799523935 3606 4912240
SGTC_3349 9149703 23.001 µM -0.63172982678811 0.27699953031878 no 2434 0.26378171724604 3570 4910494
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.631981122469504 0.276916281855757 no 2435 0.26369960632292 3629 94937 An inhibitor of serotonin biosynthesis.
SGTC_1467 k284-1082 293 µM -0.632044873400995 0.276895164590914 no 2436 0.263678777764468 3554 3334705
SGTC_1652 st011932 78 µM -0.632665183798847 0.276689730198002 no 2437 0.263476155189778 3546 1551076
SGTC_1675 st018485 24.5 µM -0.632938641842446 0.276599190090514 no 2438 0.263386856167499 3525 3323024
SGTC_2804 7954240 19.48 µM -0.633342949994185 0.27646535301073 no 2439 0.2632548557391 3576 828705
SGTC_955 1216-0110 33 µM -0.634067435450016 0.276225607930432 no 2440 0.2630184068656 3542 3619719
SGTC_345 1362-0200 395 µM -0.634385852590089 0.276120270338082 no 2441 0.262914520046289 3508 1419823
SGTC_2348 9022543 33.42 µM -0.634537057878007 0.276070256064729 no 2442 0.262865195135993 3583 3162678 YDL140C RPO21
SGTC_1583 clindamycin 39.6 µM -0.635467249521676 0.275762673840938 no 2443 0.262561860012922 3506 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2090 5301565 104.445 µM -0.635552483009626 0.27573449849801 no 2444 0.262534074369067 3587 2056344
SGTC_116 0155-0182 31.788 µM -0.636475482299259 0.275429476431615 no 2445 0.262233278151486 3561 771486
SGTC_2456 5770359 74.46 µM -0.637351425956969 0.275140158372246 no 2446 0.261947980266483 3576 3118787
SGTC_2906 7926292 26.41 µM -0.640717695982823 0.274029697581767 no 2447 0.260853057402945 3582 2966319
SGTC_1103 duloxetine 36.1 µM -0.640776649867956 0.274010269701244 no 2448 0.260833902886619 3639 60835 A selective serotonin reuptake inhibitor.
SGTC_2064 5220758 200 µM -0.641518944749649 0.273765709369567 no 2449 0.260592788179555 3634 788518
SGTC_728 3030-5151 22.5 µM -0.641557269535059 0.273753085617797 no 2450 0.260580342510183 3611 3125388
SGTC_1828 st055811 49 µM -0.642094358908596 0.273576204734933 no 2451 0.260405959204316 3563 5877589
SGTC_2486 5283202 22.39 µM -0.642387842088163 0.273479575144274 no 2452 0.260310695871917 3533 1377751
SGTC_1431 4049-0260 9.09 µM -0.642539473419878 0.273429657017612 no 2453 0.260261484053031 3574 3854841
SGTC_2263 7948595 193.29 µM -0.642976465484764 0.273285821320898 no 2454 0.260119685473696 3568 2971371
SGTC_429 1112-0049 25.5 µM -0.643318835046268 0.273173156758796 no 2455 0.260008618569888 3537 2836170
SGTC_1653 st012112 65 µM -0.643796593426889 0.273015977873481 no 2456 0.259853671539316 3596 720429
SGTC_2787 5284540 71.43 µM -0.645282898966791 0.272527281499196 no 2457 0.259371936386652 3587 736958
SGTC_38 0929-0051 58.268 µM -0.645469510320145 0.272465954500083 no 2458 0.259311485310876 3583 1379719
SGTC_1944 st076371 56.9 µM -0.645922718427477 0.272317043048339 no 2459 0.259164702921762 3539 24208455
SGTC_3047 9092122 49.47 µM -0.646049398231078 0.272275426855586 no 2460 0.259123682290406 3544 17173831
SGTC_2083 5306046 65.942 µM -0.646414156614302 0.272155615974004 no 2461 0.259005587350185 3611 539837
SGTC_199 4063-0024 41.6 µM -0.64641738094266 0.272154557007263 no 2462 0.259004543558994 3620 306215
SGTC_3308 9128332 17.569 µM -0.647342231741768 0.2718508926715 no 2463 0.258705237358773 3612 17332805 YDL196W YDL196W
SGTC_1065 prochlorperazine maleate 2.48 µM -0.648629183193574 0.27142861736719 no 2464 0.258289043910059 3628 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_825 1988-2224 89.6 µM -0.649223463874647 0.271233731976489 no 2465 0.258096973791458 3596 1180859
SGTC_1530 rhein 70.4 µM -0.649270011667403 0.271218470275852 no 2466 0.258081932782677 3621 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_383 2324-0395 7.37 µM -0.650368662094763 0.270858378316925 no 2467 0.25772705740687 3603 3146421
SGTC_1059 3448-6867 171 µM -0.651033195964623 0.27064068759814 no 2468 0.257512529152014 3586 3934407
SGTC_2968 9090663 33.37 µM -0.651135733157106 0.27060710582899 no 2469 0.257479435828259 3547 25236811
SGTC_414 piperonyl butoxide 100 µM -0.65119818662573 0.270586652827168 no 2470 0.257459280392044 3557 5794 A potent inhibitor of cytochrome P450.
SGTC_2362 9071156 126 µM -0.651278937810893 0.27056020861707 no 2471 0.257433220999198 3610 653133
SGTC_328 k915-0120 63.5 µM -0.651526382214338 0.270479184140059 no 2472 0.257353376205076 3577 6624543
SGTC_763 3453-1109 128 µM -0.651543833482977 0.270473470263996 no 2473 0.257347745555485 3612 1560353
SGTC_1897 st060201 15 µM -0.652257895180499 0.270239724669522 no 2474 0.25711740855505 3557 611878
SGTC_1765 st044815 90.4 µM -0.652532188630786 0.270149962530629 no 2475 0.257028957412376 3572 645695
SGTC_122 0236-0016 402.397 µM -0.653719696680168 0.269761524343053 no 2476 0.25664620551225 3654 6808838
SGTC_1236 0330-0013 258 µM -0.653792860084381 0.269737601478505 no 2477 0.25662263354484 3572 4617066
SGTC_2848 9016370 25.97 µM -0.653917864990692 0.269696730012907 no 2478 0.256582361762409 3624 7894410
SGTC_3042 9091578 49.47 µM -0.654466405242197 0.269517416579514 no 2479 0.25640568206987 3570 25236497
SGTC_818 4072-2707 53.5 µM -0.655542252210054 0.269165904381506 no 2480 0.2560593459974 3555 882871
SGTC_2284 7945075 39.21 µM -0.656146190563244 0.268968680048277 no 2481 0.255865033482355 3653 1245402
SGTC_2158 5657123 3.6195 µM -0.657131681631727 0.268647010302543 no 2482 0.255548124642464 3590 2858827
SGTC_3048 9093155 49.47 µM -0.65778255370318 0.268434668100153 no 2483 0.25533893323918 3593 25236002
SGTC_790 1575-0012 79.1 µM -0.65890253727012 0.268069479400234 no 2484 0.254979178227963 3639 378741 YLR208W SEC13
SGTC_1794 st048918 76.9 µM -0.659067132621233 0.268015831517507 no 2485 0.254926330167956 3555 672303
SGTC_1154 4088-0362 150 µM -0.660245448248721 0.267631931585136 no 2486 0.254548165592097 3620 6618304
SGTC_430 0958-0115 16.4 µM -0.661367305757031 0.267266683685937 no 2487 0.254188393777053 3577 6833180
SGTC_191 3914-0123 66.505 µM -0.661383969787725 0.267261260203416 no 2488 0.254183051750177 3527 3144412
SGTC_113 0099-0221 2.5 µM -0.662089653260625 0.267031639146085 no 2489 0.253956883215603 3648 89219
SGTC_394 menadione 8.33 µM -0.66399019791239 0.266413720247391 no 2490 0.253348292371049 3586 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2821 7996764 71.43 µM -0.664193944229388 0.266347519722388 no 2491 0.253283094422644 3699 2987135
SGTC_2751 anetholtrithion 17.25 µM -0.665106897387273 0.266050988497368 no 2492 0.2529910616795 3598 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1923 st058458 19.1 µM -0.665194798966917 0.266022446502553 no 2493 0.252962953337049 3679 3534982
SGTC_82 0054-0107 293.755 µM -0.665493769699641 0.265925381118731 no 2494 0.252867363582808 3635 3104697
SGTC_3108 9121785 49.47 µM -0.666853186794208 0.265484252158015 no 2495 0.252432957768888 3581 17140271
SGTC_541 4513-1321 94 µM -0.666854362689223 0.265483870742485 no 2496 0.252432582178431 3575 747515
SGTC_2718 lomofungin 53.02 µM -0.667456173784591 0.26528870264608 no 2497 0.252240397460239 3649 5351222 A RNA synthesis inhibitor.
SGTC_3264 9137442 49.47 µM -0.667942144020236 0.265131155058687 no 2498 0.25208526214208 3669 17015726
SGTC_513 4245-1575 41.7 µM -0.668948442341735 0.26480507249532 no 2499 0.251764183611291 3612 719745
SGTC_1949 st076024 69.1 µM -0.669878005326883 0.26450403664034 no 2500 0.251467780917405 3610 2921930
SGTC_399 oxolinic acid 75 µM -0.670318609092336 0.26436140944515 no 2501 0.251327353384988 3602 4628 A DNA gyrase inhibitor.
SGTC_1508 1080-0625 72.9 µM -0.670683840964999 0.264243210459327 no 2502 0.251210979525316 3570 767111
SGTC_731 3966-0296 387 µM -0.672634361081743 0.263612424978997 no 2503 0.250589967933382 3661 660956
SGTC_3347 9188721 44.724 µM -0.673941631778148 0.263190092575572 no 2504 0.250174211384566 3624 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3230 9131665 49.47 µM -0.67418497893676 0.263111513989648 no 2505 0.250096859119826 3571 15943720
SGTC_797 k781-0471 270 µM -0.675285460999601 0.262756309990155 no 2506 0.249747209616903 3631 23738129
SGTC_2702 st077768 96.8 µM -0.675486251062118 0.262691527195117 no 2507 0.249683441818497 3572 6484119
SGTC_1231 0242-0792 125 µM -0.677905527597828 0.261911616036148 no 2508 0.248915797504118 3635 3707635
SGTC_868 0527-0199 213 µM -0.678735230114394 0.261644415451725 no 2509 0.24865281975989 3602 2849450
SGTC_1395 3486-0190 4.35 µM -0.679434250729731 0.261419408797385 no 2510 0.248431377108025 3666 6748079
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.680120707309807 0.261198543106698 no 2511 0.248214016943792 3653 91467 include heat shock
SGTC_923 1900-2434 73.3 µM -0.680177168170209 0.261180381234574 no 2512 0.248196143646283 3631 5910570
SGTC_360 0957-0399 1.01 µM -0.680943329367864 0.260933992877948 no 2513 0.247953674876916 3643 6752301 YPR165W RHO1
SGTC_2508 celastrol 40.54 µM -0.681214966900071 0.26084666618013 no 2514 0.247867739495276 3604 122724 Celastrol is a natural product and antioxidant.
SGTC_2187 6125751 200 µM -0.681305718735389 0.260817494408986 no 2515 0.24783903274386 3633 874498
SGTC_2168 5727979 200 µM -0.681485766923715 0.260759623693333 no 2516 0.247782084895106 3591 695210
SGTC_2151 5563267 85.4165 µM -0.682364364279252 0.260477321564616 no 2517 0.247504291605729 3650 5310824
SGTC_1266 0828-0227 32.9 µM -0.683170350902862 0.260218488472969 no 2518 0.247249602663438 3620 3913820
SGTC_3119 9125183 49.47 µM -0.684590512828929 0.259762742984927 no 2519 0.246801177693654 3522 22695334
SGTC_2012 4023501 200 µM -0.685639426820808 0.259426399672698 no 2520 0.246470256323092 3636 3477460
SGTC_1014 4130-3005 69.3 µM -0.68621469777207 0.259242029651168 no 2521 0.246288865374035 3675 743608
SGTC_1600 coumarin 106 71.1 µM -0.687713882289885 0.258761870661127 no 2522 0.2458164880725 3704 100336 A hepatotoxic, DNA x-linker.
SGTC_1022 4477-0945 21.3 µM -0.688826162283714 0.258405927152757 no 2523 0.245466334840635 3644 4648966
SGTC_1174 0739-0097 51.1 µM -0.689364452402368 0.258233758715002 no 2524 0.245296973768388 3667 728447
SGTC_2399 5884133 200 µM -0.690497366000798 0.257871598355143 no 2525 0.244940732896655 3674 722445
SGTC_3219 9131112 49.47 µM -0.690558778328586 0.257851974108115 no 2526 0.244921429954052 3603 17612988 YMR079W SEC14
SGTC_3333 9141820 12.094 µM -0.691889152575052 0.257427044679656 no 2527 0.244503471634722 3653 1939433
SGTC_3190 9110366 49.47 µM -0.69204693957451 0.257376670721339 no 2528 0.244453925829651 3590 17123768
SGTC_780 0109-0199 192 µM -0.693966472774491 0.256764264603708 no 2529 0.243851617463644 3682 610414
SGTC_1602 st001878 87.6 µM -0.694274470356106 0.25666607200423 no 2530 0.243755049042812 3679 595405 YLR310C CDC25
SGTC_2524 avocatin b 10.57 µM -0.694834611516664 0.25648754372859 no 2531 0.243579477382707 3618 6710748
SGTC_1749 st037932 54.2 µM -0.695241152164916 0.256358011558682 no 2532 0.243452093330764 3675 594497
SGTC_1931 st074438 57.1 µM -0.697505983111459 0.255637014572048 no 2533 0.242743098183731 3643 2787313
SGTC_150 3970-0969 77.2 µM -0.698075563425124 0.255455858478519 no 2534 0.242564969670176 3734 6615640
SGTC_1024 4507-0395 26 µM -0.700964160704024 0.254538168396458 no 2535 0.241662690870194 3704 4201836
SGTC_1499 4480-0877 67.3 µM -0.701227068466385 0.254454730005347 no 2536 0.241580659872856 3628 2861909
SGTC_288 1315-0019 35.1 µM -0.703533565609703 0.253723337542188 no 2537 0.240861648220399 3731 6811474
SGTC_1399 3562-5772 25 µM -0.703966981072233 0.253586024394319 no 2538 0.240726668303324 3633 23847490
SGTC_3160 9100216 49.47 µM -0.704873893400401 0.253298826003178 no 2539 0.24044435903747 3620 17191039
SGTC_2246 7293507 91.5585 µM -0.707179739150994 0.252569388217594 no 2540 0.239727393889586 3734 887656
SGTC_2065 5221596 34.26 µM -0.710283228827303 0.251589371326104 no 2541 0.238764258909472 3675 788581
SGTC_229 benomyl 22.8748 µM -0.710935127143224 0.251383771121291 no 2542 0.238562218575884 3694 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1176 0848-0131 83.3 µM -0.713067553505213 0.25071185261687 no 2543 0.23790197807328 3766 6769040
SGTC_3011 9081274 71.4286 µM -0.713246260730342 0.250655585952866 no 2544 0.237846692392827 3696 6625322
SGTC_784 4579-0127 173 µM -0.71386572426932 0.250460597238335 no 2545 0.237655106884909 3807 1948547
SGTC_3353 9151644 39.2805 µM -0.714119070447651 0.250380874556416 no 2546 0.237576777271104 3723 4909158
SGTC_1524 corynanthine 62.1 µM -0.715331040864222 0.249999679274407 no 2547 0.237202256134151 3769 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2877 9040724 71.43 µM -0.716058275587032 0.249771093521029 no 2548 0.23697768302116 3681 6463895
SGTC_976 1348-1067 47.6 µM -0.719079612786467 0.248822610768009 no 2549 0.236045934006263 3747 5310671 YGL099W LSG1
SGTC_2292 7671323 168.05 µM -0.720280487248099 0.248446155706748 no 2550 0.235676158145984 3718 937504
SGTC_3071 9117417 49.47 µM -0.720493082542714 0.248379542098503 no 2551 0.235610728645201 3638 45595590 YGL055W OLE1
SGTC_886 0866-0150 153 µM -0.720640898607661 0.248333231720361 no 2552 0.23556524186363 3727 271463
SGTC_3014 9081533 49.47 µM -0.721230907183102 0.2481484294742 no 2553 0.235383729414205 3706 21367265
SGTC_1487 3970-0795 2.82 µM -0.723903822576115 0.247312139680821 no 2554 0.234562391519712 3771 3765103
SGTC_644 1498-1197 63.3 µM -0.725149938221807 0.246922776171016 no 2555 0.234180025489369 3759 6741615
SGTC_1668 st014914 51.6 µM -0.725362676035177 0.246856336535374 no 2556 0.234114782173984 3720 2839556
SGTC_3128 9127691 49.47 µM -0.727009676909488 0.246342289617229 no 2557 0.233610013883653 3711 41316314
SGTC_559 1550-0661 158 µM -0.728797594354319 0.245784911271668 no 2558 0.233062741665257 3753 5830875
SGTC_2143 5623677 140.463 µM -0.729086008480061 0.245695062419309 no 2559 0.232974526333783 3680 5375313
SGTC_519 k048-0011 62.8 µM -0.729712624411958 0.245499915297109 no 2560 0.232782931369669 3762 6836379
SGTC_2286 7945697 125 µM -0.729780513788574 0.245478777496253 no 2561 0.232762178677006 3728 1245733
SGTC_2298 7976326 193.81 µM -0.732208695328493 0.244723390676744 no 2562 0.232020598921735 3617 2235818
SGTC_1730 st033808 45.1 µM -0.733065191573746 0.244457240793696 no 2563 0.231759334516579 3703 1045166
SGTC_1649 st011737 51.3 µM -0.7347237900643 0.243942287285231 no 2564 0.231253864312113 3739 1761035
SGTC_975 1335-0046 28.5 µM -0.738791628630204 0.242681806580549 no 2565 0.230016767957779 3740 16486740
SGTC_946 3434-1334 87.4 µM -0.740281590255308 0.242221003482576 no 2566 0.229564574600398 3730 4047976
SGTC_1070 indatraline 8.81 µM -0.740367789999897 0.242194358854136 no 2567 0.229538428805832 3742 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2756 carbadox 75.1 µM -0.740379867733109 0.242190625713441 no 2568 0.229534765564774 3758 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_45 0kpi-0036 14.9 µM -0.743747738858293 0.241150858995102 no 2569 0.228514551225763 3719 2795021
SGTC_3324 9138759 60.749 µM -0.744688799699563 0.240860758560148 no 2570 0.228229935816538 3779 45595710
SGTC_1987 st072290 61.9 µM -0.745061059498723 0.24074605461419 no 2571 0.228117404209998 3757 54697379
SGTC_1757 st041620 31.8375 µM -0.745087055643484 0.240738045565234 no 2572 0.228109546917826 3810 5289815
SGTC_563 tetrahydrosecaminediol 614 µM -0.745141941546603 0.240721136461664 no 2573 0.228092958243375 3791 334274 A psychoactive constituent of the cannabis plant.
SGTC_1824 st053723 68.6 µM -0.745298261131079 0.240672981480561 no 2574 0.228045716046408 3727 675225
SGTC_1851 st056236 18.9 µM -0.747711603278384 0.239930205872949 no 2575 0.227317065394721 3735 5393171
SGTC_985 1493-0307 8.71 µM -0.749025078897119 0.239526471882609 no 2576 0.226921044927392 3735 3278274
SGTC_2999 9069765 71.4286 µM -0.749418112421546 0.239405734019487 no 2577 0.22680261873987 3784 2097066
SGTC_2313 7726885 200 µM -0.749867016912676 0.239267873556012 no 2578 0.226667400559303 3758 726423
SGTC_1900 st060200 72.8 µM -0.750453529776329 0.239087818352448 no 2579 0.226490800814442 3743 688945
SGTC_3157 9099274 49.47 µM -0.751872328544783 0.238652563841415 no 2580 0.226063920187454 3722 17217662
SGTC_2451 5856223 45.7 µM -0.753813113242744 0.23805787908193 no 2581 0.225480724391921 3744 2179896
SGTC_1521 st012942 49.4 µM -0.753993377092296 0.238002684859682 no 2582 0.225426599292504 3807 24207259
SGTC_874 0599-0792 117 µM -0.755435197883574 0.23756147241559 no 2583 0.224993950353871 3765 765305
SGTC_2476 5806916 10.51 µM -0.755666044879658 0.237490872499856 no 2584 0.224924723542748 3690 2870194
SGTC_1930 st074634 34.3 µM -0.75595892391648 0.237401317907963 no 2585 0.224836911830413 3701 684253 YOR116C RPO31
SGTC_3164 9100705 49.47 µM -0.756114024812 0.2373538997044 no 2586 0.224790416971983 3748 17174235
SGTC_1609 st001574 46.4 µM -0.75779673418558 0.236839788002104 no 2587 0.224286338885854 3773 3960012
SGTC_2743 auranofin 4.32 µM -0.758338015859398 0.236674542552159 no 2588 0.224124327245543 3716 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_998 3996-0085 177 µM -0.759721730722464 0.236252402897763 no 2589 0.223710468239849 3799 715391
SGTC_3152 9099253 49.47 µM -0.759779338648186 0.236234837036703 no 2590 0.223693247556411 3743 25236131
SGTC_1098 clofazimine 15.1 µM -0.761527488135649 0.235702131933219 no 2591 0.223171033445896 3845 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_598 3937-0236 20.2 µM -0.762334294860974 0.235456501242163 no 2592 0.222930255227168 3844 1379313
SGTC_1198 1612-1005 86.7 µM -0.76291566554741 0.235279591705688 no 2593 0.222756846464304 3824 6998509
SGTC_3150 9097574 49.47 µM -0.76299885656359 0.235254282906325 no 2594 0.222732038892061 3747 17217476
SGTC_2584 androsterone 48.74 µM -0.763656145311137 0.23505437200289 no 2595 0.222536090672511 3796 2754130 A steroid.
SGTC_2138 5575593 77.673 µM -0.763776658190346 0.235017728829768 no 2596 0.222500174534401 3759 762213
SGTC_833 3852-0053 558 µM -0.765018398440486 0.234640348856554 no 2597 0.222130294488913 3837 3123681
SGTC_628 1636-0253 16 µM -0.765312549080826 0.234551002016692 no 2598 0.222042726598548 3796 4456143
SGTC_733 4069-0007 56.1 µM -0.767967719375731 0.233745359011406 no 2599 0.221253181566458 3794 5717425 YNL287W SEC21
SGTC_127 0180-0333 59.125 µM -0.769672596170008 0.233228867803152 no 2600 0.220747064840974 3716 771601
SGTC_1856 st057054 55.7 µM -0.770061689897513 0.233111080977998 no 2601 0.220631649877178 3797 1266018
SGTC_2522 biochanin a 4.94 µM -0.770456476206076 0.232991604651791 no 2602 0.220514581689679 3747 5280373 A possible chelator.
SGTC_1150 3909-7983 10.9 µM -0.7710341081165 0.232816854066267 no 2603 0.220343357432793 3776 23965914
SGTC_2329 6138490 200 µM -0.771087007726886 0.232800854024278 no 2604 0.22032768050211 3886 720019
SGTC_535 2293-4129 48.2 µM -0.772243394805031 0.232451245324076 no 2605 0.219985142129343 3787 396118 YIL048W NEO1
SGTC_227 fluconazole 33.516 µM -0.772329388759444 0.232425258575467 no 2606 0.219959681703283 3780 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_3213 9129884 49.47 µM -0.773261829410471 0.232143585552886 no 2607 0.219683720460827 3782 17190742
SGTC_617 3770-0098 35 µM -0.773582130709338 0.232046872332306 no 2608 0.219588971318001 3737 5962639
SGTC_1971 st069429 63.5 µM -0.774676330782801 0.231716653882906 no 2609 0.2192654702994 3795 1246522 YGL099W LSG1
SGTC_3250 9135583 49.47 µM -0.774937403428646 0.231637903522473 no 2610 0.219188324484569 3825 7699353
SGTC_2915 7971052 15.16 µM -0.775788063409836 0.231381412624059 no 2611 0.218937066492714 3638 5741558
SGTC_2831 7999036 19.48 µM -0.775865038010237 0.231358211068539 no 2612 0.218914338813034 3849 2988270
SGTC_1803 st050068 52.4 µM -0.776396631170636 0.231198014572979 no 2613 0.218757416574514 3861 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.776560814004993 0.231148550310564 no 2614 0.218708964143465 3855 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2123 5259487 200 µM -0.777364405427604 0.230906533122339 no 2615 0.218471903267951 3778 2173474
SGTC_1635 st007035 42.4 µM -0.777585255803607 0.230840044529498 no 2616 0.21840677795207 3786 3716403
SGTC_2447 5741742 33.78 µM -0.77875947469794 0.230486717089809 no 2617 0.218060707018677 3844 1776504
SGTC_921 1561-0023 372 µM -0.780404779179276 0.22999214691735 no 2618 0.217576327844687 3779 24050882
SGTC_1545 lovastatin 49.4 µM -0.782364769026606 0.229403759884074 no 2619 0.21700011627938 3878 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_890 0929-0006 47.2 µM -0.785891389486111 0.228347199683353 no 2620 0.215965559729867 3788 1378169
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.787154226619707 0.227969525173805 no 2621 0.215595794407819 3614 4000243
SGTC_1874 staurosporine 7.6 µM -0.790514015438947 0.226966431944001 no 2622 0.214613820189803 3867 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2118 5526350 200 µM -0.791248179513681 0.226747572930072 no 2623 0.214399590760151 3868 743594
SGTC_1643 st009866 20.2 µM -0.791309627280508 0.22672926035923 no 2624 0.214381665913897 3788 3156273 YOR207C RET1
SGTC_2249 haloperidol 116.36 µM -0.792045478814014 0.226510027842202 no 2625 0.214167079362076 3821 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3343 9148379 18.9835 µM -0.792752073778088 0.226299624434017 no 2626 0.213961142184998 3871 1955036
SGTC_3251 9135047 49.47 µM -0.792795577362402 0.226286673942101 no 2627 0.21394846682907 3826 17682963
SGTC_694 1315-0438 43.2 µM -0.793257458894982 0.226149203207053 no 2628 0.213813918377421 3784 6793154
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.794979820881792 0.225636989459725 no 2629 0.213312620199307 3772 5355888
SGTC_2006 4011487 200 µM -0.797542617316123 0.224876055098614 no 2630 0.212567981077643 3885 45595294
SGTC_180 1486-1293 102.781 µM -0.799547715655995 0.22428172575007 no 2631 0.211986445239544 3781 4140536
SGTC_1523 st012844 44.7 µM -0.800939151193113 0.223869816318819 no 2632 0.211583436634121 3961 4274103
SGTC_1158 4092-0494 91.8 µM -0.802819324395067 0.223313908481886 no 2633 0.211039585565482 3948 1148199
SGTC_3090 9117696 49.47 µM -0.803529516803217 0.223104131605117 no 2634 0.210834371672601 3785 7923821
SGTC_2523 spermine 47.74 µM -0.804853805900807 0.22271326247961 no 2635 0.210452023977511 3841 1103 A DNA binding polyamine.
SGTC_3199 9111318 49.47 µM -0.805401096857863 0.222551841452688 no 2636 0.210294129502359 3805 8548020
SGTC_2146 5545642 200 µM -0.805936393247239 0.222394022721242 no 2637 0.210139762794517 3819 825326
SGTC_457 grayanotoxin iii 135 µM -0.808925669999054 0.221513883807882 no 2638 0.209278951207654 3764 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_52 0329-0193 875 nM -0.809021026000876 0.221485840753033 no 2639 0.2092515260761 3927 3739292
SGTC_2588 indole-3-carbinol 100 µM -0.809124525289268 0.221455405152432 no 2640 0.209221761266026 3893 3712 Induces cell cycle arrest.
SGTC_532 1548-0774 215 µM -0.810924456209735 0.220926489538474 no 2641 0.208704527387643 3988 5932993
SGTC_1740 st038286 13.222 µM -0.811862157825073 0.220651229586387 no 2642 0.20843536531572 3888 716786
SGTC_3178 9107506 49.47 µM -0.812313316525451 0.220518863115072 no 2643 0.208305935679915 3894 8897194
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.812694940770108 0.22040693304575 no 2644 0.208196491301888 3921 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2981 9013952 38.96 µM -0.814444016037844 0.219894347577112 no 2645 0.207695315829315 3812 2996344
SGTC_154 3389-1638 511.116 µM -0.814739189416073 0.219807911337496 no 2646 0.207610807962159 3834 5238686
SGTC_3311 9131146 2.8755 µM -0.816029186472085 0.219430387736341 no 2647 0.207241721485093 3838 4900406 YPR165W RHO1
SGTC_1734 st037168 69.4 µM -0.81739213988432 0.21903191815493 no 2648 0.206852183050127 3930 708907
SGTC_3197 9113331 49.47 µM -0.818076690976463 0.218831941638539 no 2649 0.206656698772132 3842 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_103 0844-0104 51.839 µM -0.818450959818861 0.218722651677574 no 2650 0.206549866720543 3843 5375804
SGTC_1408 3909-7976 48.8 µM -0.819575666550343 0.218394416021509 no 2651 0.206229025088462 3914 24152374
SGTC_2525 harmine 47.85 µM -0.819832054101865 0.218319631324706 no 2652 0.206155927569238 3863 5280953 A monoamine oxidase inhibitor
SGTC_1604 st002052 72.4 µM -0.820276958124884 0.218189894003001 no 2653 0.206029119414989 3900 6254834 YHR062C RPP1
SGTC_1518 st038567 90.8 µM -0.82196777488183 0.217697244717576 no 2654 0.205547618834458 3832 77966
SGTC_2385 9074692 200 µM -0.823047987113837 0.217382842097217 no 2655 0.205240352578229 3898 17046906
SGTC_286 k060-0067 22.9 µM -0.823116145130681 0.217363013071225 no 2656 0.205220974194396 3854 5985051
SGTC_3177 9107506 49.47 µM -0.823912485296873 0.217131413397806 no 2657 0.204994642865294 3775 8897194
SGTC_3126 9127922 49.47 µM -0.825255493680276 0.216741149306192 no 2658 0.204613276880647 3874 45595682
SGTC_686 1319-0111 510 µM -0.82577413470566 0.216590546325939 no 2659 0.20446611457659 3879 4562600
SGTC_1484 3473-2379 286 µM -0.82690816226751 0.216261458385088 no 2660 0.204144558357961 3972 671917
SGTC_2350 9023895 38.85 µM -0.828498714552258 0.215800377830669 no 2661 0.203694061309008 3907 2997209
SGTC_270 tamoxifen 5.46 µM -0.829009639911024 0.21565238816694 no 2662 0.203549476213447 3909 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2175 5807670 165.306 µM -0.82905762813641 0.215638491388456 no 2663 0.203535899327828 3859 241186
SGTC_2046 4110841 106 µM -0.830302754178653 0.215278100311804 no 2664 0.203183815646149 3898 44119630 YMR134W ERG29
SGTC_1972 st070201 17.4 µM -0.830738867086506 0.21515195386382 no 2665 0.203060582232541 3835 2829099
SGTC_3310 9130229 44.1445 µM -0.83513100985552 0.213883912835174 no 2666 0.201821974286203 3967 7761258
SGTC_1911 st060208 74.3 µM -0.835259531807279 0.213846873333769 no 2667 0.201785798658763 3937 688783
SGTC_1411 3909-8223 150 µM -0.838667193246849 0.212866162419285 no 2668 0.200828046510176 3883 X1411
SGTC_329 k048-0121 21.3 µM -0.840020580676153 0.21247739257718 no 2669 0.20044842364514 3906 6832902
SGTC_1968 st069590 43.6 µM -0.840205116239316 0.212424415621742 no 2670 0.200396695146195 3895 6384066
SGTC_435 c-PAF 6.7 µM -0.841909379160278 0.211935516212506 no 2671 0.199919339989923 3907 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1104 tacrolimus 29.8 µM -0.842319636747906 0.211817924584538 no 2672 0.199804531174834 3915 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_19 0279-0214 38.434 µM -0.842923808669549 0.211644821053089 no 2673 0.199635528494542 3945 3566274 YBR002C RER2
SGTC_1152 3909-8331 15.9 µM -0.843270601179563 0.211545497665882 no 2674 0.199538560432778 3860 16001939
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.844362650600215 0.211232906704848 no 2675 0.199233393296074 3871 6312947
SGTC_2205 7238770 200 µM -0.845755452491485 0.210834620555071 no 2676 0.198844590684439 3940 279867
SGTC_1437 4092-1038 11.6 µM -0.846499998298302 0.210621890725369 no 2677 0.198636937402816 3910 3977136
SGTC_2696 st077691 74.316 µM -0.848602689303706 0.210021795417346 no 2678 0.198051205014967 3927 757133
SGTC_2237 6667747 47.222 µM -0.849388709419642 0.209797728243304 no 2679 0.197832516809566 3897 729940 YDL015C TSC13
SGTC_1674 st016616 23.6 µM -0.851262513568066 0.209264138609927 no 2680 0.197311771771883 3875 625830
SGTC_1288 0973-0013 65.5 µM -0.852924232833061 0.208791611843824 no 2681 0.196850661173413 3947 4315430
SGTC_2926 9010726 65.15 µM -0.853821504988998 0.208536725005474 no 2682 0.196601948563243 3944 2994293
SGTC_1590 st077108 57.8 µM -0.855434336044052 0.208079031900635 no 2683 0.196155370897168 3906 5489485
SGTC_2455 5377712 9.75 µM -0.856178615546105 0.207868018558084 no 2684 0.195949494548846 3911 2243908
SGTC_2918 7977171 22.06 µM -0.856765094776799 0.207701832788799 no 2685 0.195787359974081 3833 2236483
SGTC_205 1486-1330 71.903 µM -0.85950049672986 0.206927761964084 no 2686 0.1950322230362 3907 4118834
SGTC_2004 4023728 41.89 µM -0.862403422127809 0.20610815516233 no 2687 0.194232779022525 3933 360084 YDR527W RBA50
SGTC_207 4185-0010 4.486 µM -0.863176868973645 0.205890106736776 no 2688 0.19402011469587 3969 3761753
SGTC_2709 st078560 56 µM -0.863381961259394 0.205832310535794 no 2689 0.193963747021525 3893 17250903
SGTC_131 0141-0277 33.849 µM -0.8640337963672 0.205648683530551 no 2690 0.193784662579074 3895 1547771
SGTC_2207 7258803 200 µM -0.865892099005925 0.205125719289749 no 2691 0.193274668166271 3890 3666799
SGTC_3186 9110464 49.47 µM -0.867161508178498 0.204768936440364 no 2692 0.192926761601337 3937 17018021
SGTC_2551 apiole 73.87 µM -0.867464676885848 0.204683781829057 no 2693 0.192843728868125 3752 10659 A possible DNA adduct former.
SGTC_1397 3532-0190 20.1 µM -0.867785238362902 0.204593764820438 no 2694 0.192755956300847 3844 5322280
SGTC_637 1181-0519 7.26 µM -0.868113161241352 0.204501705030516 no 2695 0.192666193377203 3946 6252091 YGR060W ERG25
SGTC_198 3454-2873 16.191 µM -0.870204598092725 0.203915143443771 no 2696 0.192094301789967 3905 710957
SGTC_301 4119-0100 24.5 µM -0.870841494915551 0.20373671955149 no 2697 0.191920352478334 3950 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3237 9133362 49.47 µM -0.871146758449667 0.203651234297791 no 2698 0.191837013069602 3865 43845137
SGTC_274 sirtinol 40.1 µM -0.87429932308416 0.202769649454153 no 2699 0.190977633940694 4001 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2659 sanguinarine 24.21 µM -0.874667741738603 0.202666773680044 no 2700 0.190877358512613 3875 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_507 nimesulide 162 µM -0.87506408771345 0.202556134427175 no 2701 0.190769517958595 3984 4495 A COX2 inhibitor.
SGTC_492 tmb-8 126 µM -0.87938151294613 0.201353273475303 no 2702 0.18959722622375 3878 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_700 3453-2283 142 µM -0.883844737164022 0.200114303792537 no 2703 0.188390016293332 4012 565664
SGTC_2669 eugenol 100 µM -0.884724185209785 0.199870714763011 no 2704 0.188152704123768 3932 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2621 lithochol-11-enic acid 100 µM -0.887270988896653 0.199166309124542 no 2705 0.1874665104286 3873 6708711
SGTC_2193 5925765 200 µM -0.887669681862745 0.199056172483922 no 2706 0.187359229458736 3943 877370
SGTC_1228 0124-0032 52.5 µM -0.888212657929834 0.198906237498252 no 2707 0.187213185604626 4026 X1228
SGTC_3018 9082602 49.47 µM -0.888384561634686 0.198858782967138 no 2708 0.187166963473089 3941 17332089
SGTC_769 0302-0231 76 µM -0.889100318242538 0.19866126959269 no 2709 0.186974583955325 3904 571869 YER009W NTF2
SGTC_2309 7664088 163.95 µM -0.88925308486597 0.198619128895492 no 2710 0.186933539519389 3977 704922
SGTC_1811 st050069 61.5 µM -0.890479147158766 0.198281114720921 no 2711 0.186604330282654 3902 3877702
SGTC_3095 9117207 49.47 µM -0.892238698086486 0.197796629716076 no 2712 0.186132502063633 3932 17015229
SGTC_2479 5617353 43.85 µM -0.892516919758629 0.197720088084109 no 2713 0.18605796395149 4004 2731746
SGTC_751 0833-0568 350 µM -0.893556892312337 0.197434139520015 no 2714 0.185779509749373 4017 6954252
SGTC_977 1348-1378 135 µM -0.894985006507423 0.197041876125573 no 2715 0.185397551505826 3960 X977
SGTC_702 1488-0190 94 µM -0.896115471551796 0.19673170342588 no 2716 0.185095547370118 3998 949357
SGTC_1357 1503-1303 39.5 µM -0.897076169171762 0.196468343441567 no 2717 0.184839137008867 3930 292895
SGTC_1361 1608-0041 5.61 µM -0.897776372984991 0.196276528368463 no 2718 0.184652391651934 3925 X1361
SGTC_2288 7946289 167.31 µM -0.897996244566685 0.196216319788972 no 2719 0.184593775797644 4016 1246052
SGTC_206 4546-0025 72.014 µM -0.899080185193719 0.195919662409593 no 2720 0.184304975798529 4013 6620745 YIL048W NEO1
SGTC_1564 D-Arginine 115 µM -0.899600778460826 0.195777281066553 no 2721 0.18416637139288 3983 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2745 rifampicin 24.3 µM -0.900984308958707 0.195399193252543 no 2722 0.183798331269723 3968 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_851 0394-0702 453 µM -0.903428738962383 0.194732270460312 no 2723 0.183149196493971 3958 762646
SGTC_712 r015-0009 80.6 µM -0.903457721489233 0.194724371367037 no 2724 0.183141508577878 4009 6813872 YLR060W FRS1
SGTC_2757 clomiphene 4.22 µM -0.904265257506247 0.194504358443593 no 2725 0.182927382214691 4050 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2491 paeonol 100 µM -0.906266127553481 0.193959874295409 no 2726 0.182397504719746 3836 11092 Increases levels of cortical cytochrome oxidase.
SGTC_941 3237-0776 460 µM -0.906562445816772 0.193879318109533 no 2727 0.182319114268304 4016 760008
SGTC_375 3970-0961 9.27 µM -0.909212068696005 0.193159906386356 no 2728 0.181619097437631 3935 2898222
SGTC_359 0081-0058 15.9 µM -0.911750008665768 0.192472348401028 no 2729 0.180950166009769 4046 3494159
SGTC_3284 9108171 64.8615 µM -0.912832964367196 0.192179418897173 no 2730 0.180665199141164 3971 8687505
SGTC_859 0439-0102 54.6 µM -0.915229586280733 0.191532125166786 no 2731 0.180035557817285 3972 610143
SGTC_3321 9137793 26.8275 µM -0.916747349583998 0.191122890346183 no 2732 0.179637523974518 3944 4904192
SGTC_1036 k216-0215 33.5 µM -0.91782668444579 0.190832195536746 no 2733 0.179354804829344 3969 622330
SGTC_2126 5251174 33.877 µM -0.918569501020293 0.190632292117232 no 2734 0.179160395333608 4005 790722
SGTC_2958 9077254 16.72 µM -0.918915320512857 0.190539270614225 no 2735 0.179069932906132 4071 16457351
SGTC_2747 doxorubicin 7.63 µM -0.920644272933037 0.190074620197401 no 2736 0.178618089814574 3924 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_616 4092-0450 108 µM -0.920945588950793 0.189993713798215 no 2737 0.178539417648575 4017 787165
SGTC_2184 6075246 200 µM -0.921809854599474 0.189761767189884 no 2738 0.178313883136462 4024 2267320
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.922435031041906 0.18959409455049 no 2739 0.178150852117616 4049 688788
SGTC_1420 4'-methoxyflavone 42 µM -0.922962951033255 0.189452577144712 no 2740 0.178013256442835 3980 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3076 9116187 49.47 µM -0.927325648379293 0.188285576102877 no 2741 0.176878740715093 4005 27241210
SGTC_1476 4112-3294 3.34 µM -0.92743807784969 0.188255560485479 no 2742 0.176849564057212 4034 704369
SGTC_576 1073-0113 22.7 µM -0.928263829802624 0.18803519760474 no 2743 0.176635365762691 4155 5439563
SGTC_1782 st039423 80.636 µM -0.929276107148387 0.187765275284843 no 2744 0.176373007101586 4036 2068169
SGTC_1725 st036284 20.55 µM -0.929749287715004 0.187639184478627 no 2745 0.176250454345227 4106 707914
SGTC_2741 miltefosine 3.04 µM -0.93080676849163 0.187357581406798 no 2746 0.175976763932136 3970 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1941 st076221 61.8 µM -0.93275279800757 0.186840044427172 no 2747 0.175473808735476 3931 2828568
SGTC_2955 9076254 12.21 µM -0.933859941896214 0.186546000203979 no 2748 0.175188072259015 3949 16459619
SGTC_674 0498-0004 451 µM -0.934863066467015 0.186279829868227 no 2749 0.174929436501643 4008 4231473
SGTC_2035 5154463 94.595 µM -0.935694861412569 0.186059298909933 no 2750 0.174715158543132 4042 2769623
SGTC_331 k048-0133 24.5 µM -0.937052984388142 0.185699572428182 no 2751 0.174365652009408 3970 6813582
SGTC_1217 1183-1422 255 µM -0.937782675219745 0.185506477287488 no 2752 0.174178053086267 4038 2849664
SGTC_66 0109-0187 42.4 µM -0.939122838048837 0.185152160159723 no 2753 0.173833839942504 3932 759417
SGTC_3073 9114972 49.47 µM -0.93981124358632 0.18497032052082 no 2754 0.17365719523511 4010 41905075
SGTC_418 lividomycin a 100 µM -0.941126624749444 0.184623176427032 no 2755 0.17331998643921 4034 72394 An antibiotic.
SGTC_1795 st049545 62.3 µM -0.942300674410219 0.184313673730785 no 2756 0.173019361493168 3939 5291882
SGTC_1410 3909-8106 77.9 µM -0.943659570225764 0.183955845282504 no 2757 0.17267182021246 4067 1039210
SGTC_72 0744-0168 198.391 µM -0.943798479652727 0.183919291628841 no 2758 0.172636318840353 3919 677577
SGTC_612 0302-0167 22.4 µM -0.945266954597269 0.183533142984331 no 2759 0.172261302305179 4047 235821
SGTC_1370 2001-0092 44.6 µM -0.945560677962254 0.183455966479653 no 2760 0.172186354179743 4089 790957
SGTC_1642 st009582 77.7 µM -0.945680552033927 0.183424475099221 no 2761 0.172155772409675 3978 6739311
SGTC_18 0111-0177 500 nM -0.946038152439897 0.18333055211761 no 2762 0.172064563490736 4071 721752
SGTC_3037 9091026 49.47 µM -0.9476304067449 0.182912714054379 no 2763 0.171658820483398 3985 25236398 YIL048W NEO1
SGTC_1936 st074407 74.3 µM -0.948573985902079 0.182665381472966 no 2764 0.171418663493426 4087 809813
SGTC_1338 1486-1223 76 µM -0.948664142096167 0.18264176051178 no 2765 0.171395728449153 4057 3444526
SGTC_1461 k072-0203 53.8 µM -0.948956170544142 0.182565262029987 no 2766 0.171321452118815 3934 5418714
SGTC_1954 st077032 68.9 µM -0.950630969797551 0.182126925580455 no 2767 0.170895870762783 4011 698907
SGTC_3260 9137109 49.47 µM -0.950753998436833 0.182094751898055 no 2768 0.170864634785923 3962 17478346
SGTC_1908 st060353 56.5 µM -0.95151867976764 0.181894856890071 no 2769 0.170670570304424 4095 4227716
SGTC_3323 9138564 53.9225 µM -0.952027910458833 0.181761815278298 no 2770 0.170541413603714 4060 43912313 YNL103W MET4
SGTC_415 dibenzyl ketone 100 µM -0.952372852947646 0.181671730196415 no 2771 0.170453961051409 4030 7593
SGTC_2415 st077333 57.7 µM -0.953005763540691 0.181506512117629 no 2772 0.170293575249428 4078 2766255
SGTC_638 3970-0837 4.09 µM -0.9544984039652 0.181117238552553 no 2773 0.16991570840604 4007 4118451 YLR208W SEC13
SGTC_1556 plumbagin 1.48 µM -0.957177470658055 0.18041986354605 no 2774 0.169238843216646 3947 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2933 9026794 32.47 µM -0.957675246755744 0.180290475657073 no 2775 0.169113271226264 4003 17586027
SGTC_1534 6-azauridine 81.6 µM -0.957865350313719 0.180241077046538 no 2776 0.169065330352265 4061 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1622 st003707 19.4 µM -0.958173316469697 0.180161069744233 no 2777 0.168987685066327 4070 10140899
SGTC_249 wiskostatin 11.211 µM -0.960254673955893 0.179620933254926 no 2778 0.168463528041317 3997 2775510 A n-wasp and actin depolymerizer.
SGTC_2413 inermin 26.06 µM -0.960712589418181 0.179502235576295 no 2779 0.168348349708237 4153 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1716 st033144 30.6155 µM -0.96122801946458 0.179368688361677 no 2780 0.168218765477941 4045 674617
SGTC_196 k015-0023 18.111 µM -0.962538799721785 0.179029348535554 no 2781 0.167889511484422 3976 5211998
SGTC_2229 7354935 190 µM -0.962827116774141 0.178954762140484 no 2782 0.167817145021096 3968 318112
SGTC_462 ag-879 158 µM -0.964456516456175 0.178533610984567 no 2783 0.167408549542687 4063 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.964503848845169 0.17852138631341 no 2784 0.167396689852469 4102 61125 An anti-inflammatory.
SGTC_2139 5578692 56.4705 µM -0.965878716672365 0.178166525377152 no 2785 0.167052436720658 4005 650991 YMR113W FOL3
SGTC_1434 4073-0095 163 µM -0.967229589896801 0.177818290950055 no 2786 0.166714636556134 3982 24133745
SGTC_321 4534-3890 65.3 µM -0.967506796605604 0.177746884432462 no 2787 0.166645372623023 4065 699746
SGTC_1138 3761-0006 1.03 µM -0.970310231187851 0.177025756068111 no 2788 0.165945939506387 4061 12061087
SGTC_299 1273-0059 1.44 µM -0.970844267956753 0.176888595514374 no 2789 0.165812917302657 3930 2848077
SGTC_1010 4112-3296 15.2 µM -0.971626125725806 0.176687906472793 no 2790 0.165618290205678 4131 704384
SGTC_362 0310-0100 9.03 µM -0.972334251788648 0.176506267344137 no 2791 0.165442144618199 4145 790235
SGTC_959 1222-0044 107 µM -0.97269528368592 0.176413705693299 no 2792 0.165352384990656 4047 6083612
SGTC_25 0118-0223 35.662 µM -0.974449287042961 0.175964449998713 no 2793 0.164916753775095 4040 5333628
SGTC_304 1310-0298 97 µM -0.978089970369637 0.175034270716464 no 2794 0.164014913958789 3896 1550234
SGTC_1179 1021-1431 9.29 µM -0.978335500644471 0.174971651251506 no 2795 0.163954208620027 4099 2840958
SGTC_2190 6049624 200 µM -0.979261936655767 0.174735503212053 no 2796 0.163725286243756 3931 2265554
SGTC_884 0851-0618 334 µM -0.980189190588036 0.174499349380638 no 2797 0.163496369623745 4087 9642473
SGTC_2948 9070189 9.45 µM -0.980760025279339 0.174354069565174 no 2798 0.163355547734045 4013 6473636 YDL196W YDL196W
SGTC_654 1124-0271 80.9 µM -0.981831467457871 0.174081590598926 no 2799 0.163091441441748 4063 5403748
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.982407987576435 0.173935087569533 no 2800 0.162949446402292 4101 4174840
SGTC_1758 st042942 75.2445 µM -0.982914752781083 0.173806375148885 no 2801 0.162824698169151 3999 669317
SGTC_2759 disulfiram 3.38 µM -0.983040434380382 0.173774462873949 no 2802 0.162793769278765 3974 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1068 loratadine 26.9 µM -0.984210802680466 0.17347746934521 no 2803 0.162505937689132 4103 3957 A H1 histamine antagonist.
SGTC_3207 9114163 49.47 µM -0.984826297316888 0.17332141067033 no 2804 0.162354700512597 4126 849233
SGTC_2894 9048625 32.47 µM -0.991373648426876 0.171666865290208 no 2805 0.160751581357378 4064 4092861
SGTC_3101 9120531 49.47 µM -0.991580584763123 0.171614736563004 no 2806 0.160701082070144 4094 24824904
SGTC_2488 5268135 45.7 µM -0.992534355676368 0.171374605666306 no 2807 0.160468464456134 4138 1270356 YLR208W SEC13
SGTC_1218 1348-1416 30.7 µM -0.9931747952906 0.171213482777717 no 2808 0.160312389528028 4035 6787668
SGTC_381 3461-2219 42.7 µM -0.993685859206629 0.17108497795893 no 2809 0.16018791461152 4088 2883159
SGTC_275 trichlorophene 5.69 µM -0.993700342161529 0.171081337181434 no 2810 0.160184388058503 4123 62616
SGTC_1360 1598-0022 39.8 µM -0.994524646754 0.170874202192264 no 2811 0.159983756185089 4131 761525
SGTC_1990 st072050 59.8 µM -0.997007674196881 0.170251226013696 no 2812 0.15938039247701 4069 17233948
SGTC_1804 st050076 49.1 µM -0.997160222875168 0.170213000001214 no 2813 0.159343372524898 4115 3895976
SGTC_2434 5670830 169.91 µM -0.999103078292961 0.169726635729875 no 2814 0.158872380055652 4133 1549830
SGTC_561 1550-0330 72.9 µM -0.999422495142685 0.169646759983039 no 2815 0.158795033550246 4026 6812934
SGTC_3215 9129942 49.47 µM -0.999778382911321 0.169557792452508 no 2816 0.158708884721062 4076 17682944
SGTC_3012 9080433 71.4286 µM -0.999989803641601 0.169504954066864 no 2817 0.158657721164265 4080 17688859
SGTC_1178 0988-0033 191 µM -1.00027095134514 0.169434705845839 no 2818 0.15858970052026 4141 5392207
SGTC_911 3456-4043 236 µM -1.00030793939591 0.16942546531605 no 2819 0.158580753085359 4116 914281
SGTC_636 0kpi-0074 126 µM -1.00062462658594 0.169346362263275 no 2820 0.158504159787353 4091 616434
SGTC_2586 curcumin 80 µM -1.00335191030895 0.16866611471121 no 2821 0.157845549070103 4044 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_3168 9103419 49.47 µM -1.00519459404562 0.168207502412564 no 2822 0.15740157887769 4090 16649256
SGTC_834 0312-0008 75.7 µM -1.00621359408744 0.167954235629893 no 2823 0.157156417132017 4096 6385573 YIL048W NEO1
SGTC_3226 9131256 49.47 µM -1.00729931305887 0.167684656460487 no 2824 0.156895479901561 4037 17178073
SGTC_2499 avocadenofuran 51.48 µM -1.00779104637566 0.16756265301082 no 2825 0.156777392581319 4056 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1830 st055982 50.3 µM -1.00977888385023 0.167070035662656 no 2826 0.156300619552334 4037 455313 An antimicrobial agent.
SGTC_718 1130-0073 349 µM -1.01036665028205 0.166924556972 no 2827 0.156159829806402 4146 6740020
SGTC_1910 st062352 60.4 µM -1.01377184318967 0.166083342561389 no 2828 0.155345816860744 4024 2245730
SGTC_2426 5582046 32.21 µM -1.01429907847282 0.165953340339666 no 2829 0.155220031821068 4120 2251934
SGTC_396 dithiazanine 1.25 µM -1.01462451384665 0.165873129450095 no 2830 0.155142424714954 4096 10578 An antihelmenthic.
SGTC_1401 3807-4679 7.6 µM -1.01465592122861 0.165865389718374 no 2831 0.155134936300843 4044 3291456
SGTC_187 1488-2104 32.728 µM -1.01708269906321 0.165268063927053 no 2832 0.154557044931075 4109 2852859
SGTC_2888 9058547 12.99 µM -1.01732625459705 0.165208192261015 no 2833 0.154499125439232 4006 16476514
SGTC_2325 6158266 200 µM -1.01843586782723 0.164935600979943 no 2834 0.154235431968309 4135 3623240
SGTC_2744 captopril 92.04 µM -1.01898048837999 0.164801914303819 no 2835 0.154106114857666 4139 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_822 1487-0950 154 µM -1.01951705337061 0.164670273665681 no 2836 0.153978780656967 4134 1958375
SGTC_2941 9056145 11.23 µM -1.01996294529057 0.164560930569603 no 2837 0.153873017394366 4011 2119517
SGTC_175 3793-3120 23.7 µM -1.02108099292158 0.164286966176732 no 2838 0.153608033729834 4119 5322297
SGTC_1540 guanosine 70.6 µM -1.02282657716906 0.163859823003613 no 2839 0.153194924806962 3978 6802 Guanosine is a purine nucleoside
SGTC_83 0170-0301 39.027 µM -1.02296435426058 0.163826139766419 no 2840 0.15316234994126 4103 3089716
SGTC_2497 7-hydroxyflavone 100 µM -1.02480403828751 0.163376811214837 no 2841 0.152727830294212 4139 5281894
SGTC_1877 wortmannin 25 µM -1.02492180284328 0.163348075424301 no 2842 0.152700043057479 4119 312145 A covalent inhibitor of PI 3-kinase.
SGTC_670 4204-0025 119 µM -1.02544140290997 0.163221326747198 no 2843 0.15257748042056 4119 719039
SGTC_2976 9009005 19.48 µM -1.02569976693948 0.163158326495413 no 2844 0.152516562127265 4162 2993148
SGTC_2739 tacrine 100.86 µM -1.02578051145487 0.163138640754672 no 2845 0.152497527113954 4164 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3106 9121286 49.47 µM -1.02590114115012 0.163109233770324 no 2846 0.152469092356535 4117 15943471
SGTC_1935 st074532 41.6 µM -1.02648125258271 0.162967862921184 no 2847 0.152332397995595 4109 2829742
SGTC_126 0417-1624 672.48 µM -1.02757232510722 0.162702188756615 no 2848 0.15207552393816 4189 41912 YDL195W SEC31
SGTC_2101 5377231 179.231 µM -1.02795172700648 0.162609871139461 no 2849 0.151986267804794 4167 2844213
SGTC_1012 4112-3522 18 µM -1.02887400582151 0.162385600633544 no 2850 0.15176944237968 4154 3112398
SGTC_1903 st060211 78.3 µM -1.02919894891 0.162306632218458 no 2851 0.151693098071043 4142 688960
SGTC_679 0422-0091 41.4 µM -1.02956736221641 0.162217129815559 no 2852 0.151606571456443 4125 627384 YHR062C RPP1
SGTC_2381 9035592 200 µM -1.03100296247055 0.161868671444275 no 2853 0.151269715284253 4116 4749657
SGTC_2269 7935389 174.42 µM -1.0319231330374 0.161645578238209 no 2854 0.15105406403604 4080 97605
SGTC_373 0844-0104 25.9 µM -1.03332786581039 0.161305390765112 no 2855 0.150725245469971 4142 5375804
SGTC_2839 9003951 25.97 µM -1.03603863696462 0.160650237918789 no 2856 0.150092058844789 4185 2990634
SGTC_3114 9122766 49.47 µM -1.03716825499682 0.160377739850556 no 2857 0.149828724907943 4135 17176985
SGTC_1096 rimcazole 32.2 µM -1.03833644731356 0.160096254371944 no 2858 0.149556722939122 4054 18528119 A dopamine reuptake inhibitor.
SGTC_2119 5528445 120.635 µM -1.03935146044159 0.159851941091733 no 2859 0.149320654935289 4149 791935
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.0395907054727 0.159794390438175 no 2860 0.149265048459674 4020 6708630 An antioxidant.
SGTC_230 MPP+ 141.667 µM -1.04102340727934 0.159450036127823 no 2861 0.148932342397515 4124 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1490 4089-0339 670 nM -1.04103085139295 0.159448248181682 no 2862 0.148930614999351 4095 742542
SGTC_2081 5214970 32.255 µM -1.04241835969774 0.159115222121819 no 2863 0.148608879033365 4099 2063512
SGTC_1405 3909-7894 12 µM -1.04400595182941 0.158734731829321 no 2864 0.148241317978743 4129 7104060
SGTC_3039 9090270 49.47 µM -1.04451948074576 0.158611784694443 no 2865 0.148122555502851 4157 17173750
SGTC_2879 9041815 71.43 µM -1.04527495093661 0.158431026436825 no 2866 0.147947955667937 4147 4942971
SGTC_881 0833-0569 170 µM -1.04546014517579 0.158386736400492 no 2867 0.147905175696867 4150 5418700
SGTC_987 1497-1013 404 µM -1.04607158321693 0.158240565923815 no 2868 0.147763991983476 4132 1676435
SGTC_1415 3966-0071 78.1 µM -1.04818346118248 0.157736381142148 no 2869 0.14727704447951 4069 2893185
SGTC_683 panaxydol 45 µM -1.05182189175383 0.156870228465022 no 2870 0.146440636574301 4135 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2740 felodipine 17.08 µM -1.05498642311709 0.15611944003028 no 2871 0.145715767096349 4167 3333 L-type calcium channel blocker
SGTC_119 0121-0043 24.815 µM -1.05538072111517 0.156026058576037 no 2872 0.145625618241593 4154 1092378
SGTC_16 erodoxin 22.806 µM -1.05793723780988 0.155421492906316 no 2873 0.145042028438607 4180 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2616 abietic acid 100 µM -1.05864180509882 0.155255148726619 no 2874 0.144881470164777 4187 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2859 9028643 45.46 µM -1.05892635881216 0.155188000599509 no 2875 0.144816659404974 4013 17151580
SGTC_566 0958-0068 16.5 µM -1.05905000293205 0.155158829408902 no 2876 0.144788503955535 4072 6815365
SGTC_112 phenothiazine 287.218 µM -1.06031371523862 0.154860891049024 no 2877 0.144500950838817 4105 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_350 k064-0020 19.8 µM -1.06115219651142 0.15466341571783 no 2878 0.144310369988532 4182 2790705
SGTC_1449 4112-4002 201 µM -1.06132419704585 0.154622927504438 no 2879 0.144271296437428 4209 2059539
SGTC_512 prima-1 270 µM -1.06333911904966 0.154149144897613 no 2880 0.143814095501713 4162 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2489 cantharidin 73.42 µM -1.06743373779262 0.153189310219096 no 2881 0.142888010218324 4114 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1568 digitonin 820 nM -1.06818196422224 0.153014344625141 no 2882 0.14271921937883 4165 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1685 st024049 53.0905 µM -1.07067209216443 0.152433006452813 no 2883 0.142158447724073 4185 1941139
SGTC_356 1634-0012 32.5 µM -1.07305959273249 0.151877005567159 no 2884 0.141622189599771 4182 735457
SGTC_2536 dehydroabietamide 32.04 µM -1.07536893997534 0.151340488526512 no 2885 0.141104791011774 4262 3983547
SGTC_1413 3910-0535 34.4 µM -1.07678172837836 0.151012885906839 no 2886 0.140788895013879 4190 2876951
SGTC_1082 camptothecin 424.86 nM -1.07730979375046 0.150890557401749 no 2887 0.140670944192482 4061 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1091 telmisartan 47.6 µM -1.07962660152657 0.150354639098263 no 2888 0.140154245329268 4206 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_635 k038-0028 24.7 µM -1.0797278243108 0.150331253444207 no 2889 0.140131699865173 4177 4035102
SGTC_1793 st048256 72.231 µM -1.08181119137683 0.149850468295131 no 2890 0.139668216368602 4072 672022
SGTC_2647 atorvastatin 60.16 µM -1.08291021688048 0.149597256382701 no 2891 0.139424138260589 4144 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1285 0929-0069 65.5 µM -1.09150330813084 0.147627283116518 no 2892 0.137525738515212 4208 1206237
SGTC_2678 equilin 100 µM -1.09203975054697 0.147504882132061 no 2893 0.137407814773746 4191 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1813 st051246 8.6015 µM -1.09324946921898 0.147229108158634 no 2894 0.13714214117951 4116 5291959
SGTC_1115 galangin 695.678 nM -1.09358530952503 0.147152609527367 no 2895 0.137068447543807 4253 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3086 9117350 49.47 µM -1.09395049631239 0.147069456520768 no 2896 0.136988345103126 4119 2679265
SGTC_1019 4262-0212 3.4 µM -1.09435599061116 0.146977162418007 no 2897 0.1368994388373 4212 4677213
SGTC_2435 5706476 10.6 µM -1.09499405954524 0.146832010929059 no 2898 0.136759619507251 4172 5725375
SGTC_2994 9053520 71.4286 µM -1.09872372945362 0.145985489003526 no 2899 0.135944294447861 4233 4647384
SGTC_1120 ficusin 1.78878 µM -1.09931331719665 0.145851971230076 no 2900 0.135815712790992 4246 6199 A DNA cross-linker.
SGTC_1812 st052057 4.327 µM -1.09939450410856 0.145833592109438 no 2901 0.135798013474771 4206 3645418
SGTC_3075 9116269 49.47 µM -1.09970331710212 0.145763697140603 no 2902 0.135730704508304 4230 17015205 YNL244C SUI1
SGTC_3271 9137798 49.47 µM -1.100047860389 0.145685741761762 no 2903 0.135655634730904 4139 6498326
SGTC_451 chloral hydrate 100 µM -1.10049171173718 0.145585358542368 no 2904 0.135558969442874 4214 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1008 4106-0037 6 µM -1.10113302401868 0.145440398924659 no 2905 0.135419383002629 4187 2905394
SGTC_1720 st037298 9.481 µM -1.10277932190044 0.145068721060828 no 2906 0.135061505010063 4191 597396
SGTC_3313 9133968 57.047 µM -1.10440263005534 0.144702859992576 no 2907 0.134709260210725 4192 1494643
SGTC_943 3253-1379 105 µM -1.10526918514302 0.144507810514368 no 2908 0.134521483046262 4216 668464
SGTC_2711 st079103 59.1 µM -1.10588398126678 0.144369535943591 no 2909 0.134388369514494 4149 54693780
SGTC_2986 9022445 71.43 µM -1.10636015712991 0.144262499929352 no 2910 0.13428533173633 4203 6459286
SGTC_2716 st080858 38.6235 µM -1.10674067054929 0.144177005623872 no 2911 0.134203032979404 4184 5296050
SGTC_2016 5121758 140 µM -1.11118640678502 0.143180662275061 no 2912 0.133244060518921 4116 2795203
SGTC_1211 1056-0033 32.3 µM -1.11595587770702 0.142116948781404 no 2913 0.132220510770802 4258 6741922
SGTC_716 1683-5115 658 µM -1.11839666958564 0.141574664196352 no 2914 0.131698808052109 4170 723597
SGTC_1728 st035614 33.7865 µM -1.11870074615695 0.141507204116201 no 2915 0.131633913387507 4159 15945546
SGTC_1756 st041558 35.5 µM -1.11890727417059 0.14146139782861 no 2916 0.131589849687114 4296 3955792
SGTC_3194 9111903 49.47 µM -1.11963889235019 0.141299211526787 no 2917 0.131433837501005 4246 17087251
SGTC_11 0438-0307 1.3 µM -1.11968653807783 0.141288653718185 no 2918 0.131423681831377 4199 4011476
SGTC_2183 6420625 130.508 µM -1.11974891075154 0.141274833376394 no 2919 0.131410387937353 4211 2897619
SGTC_1020 4335-0961 93.3 µM -1.11975504281949 0.141273474701451 no 2920 0.131409081019913 4161 669075
SGTC_2847 9005661 71.43 µM -1.12119273700589 0.140955171003044 no 2921 0.131102915316582 4226 2991449
SGTC_3093 9117344 49.47 µM -1.12267518847644 0.14062746787775 no 2922 0.130787734663093 4242 24824913
SGTC_2840 9008771 71.43 µM -1.12327697826207 0.140494586989684 no 2923 0.13065993907494 4163 2992978
SGTC_717 1532-0246 73.2 µM -1.12524319433246 0.140061022225628 no 2924 0.130242996985998 4192 9561992
SGTC_996 3970-0799 1.8 µM -1.12533090857407 0.140041701810221 no 2925 0.130224418388071 4215 6615648 YGL040C HEM2
SGTC_2302 7771753 200 µM -1.12699923766947 0.139674571336645 no 2926 0.129871401649166 4233 2203047
SGTC_1201 1889-3372 45.9 µM -1.12856425547488 0.13933077079864 no 2927 0.129540848275232 4093 5392199
SGTC_2974 9094440 9.66 µM -1.1287467373277 0.139290720998219 no 2928 0.129502343564755 4229 25236134
SGTC_1472 k841-0093 193 µM -1.12995873004592 0.139024920367685 no 2929 0.129246807425809 4331 X1472
SGTC_325 2810-4341 181 µM -1.1300573348491 0.139003310668522 no 2930 0.12922603300701 4210 774970
SGTC_2645 abamectin 100 µM -1.13765820841802 0.137344423503392 no 2931 0.127631615268773 4189 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_641 4092-0595 30 µM -1.13904749472114 0.137042679869591 no 2932 0.127341672566086 4268 786260
SGTC_1797 st048695 56.8 µM -1.14134123266468 0.136545487338087 no 2933 0.126863974919114 4203 592262 YIL048W NEO1
SGTC_2366 9070441 60.58 µM -1.1419170237698 0.136420872332281 no 2934 0.126744255854721 4209 6837235
SGTC_875 0709-0210 25.7 µM -1.14234654020254 0.136327965350475 no 2935 0.126655001611175 4235 6251364
SGTC_3010 9080089 71.4286 µM -1.14272471424731 0.136246199880164 no 2936 0.126576452648049 4253 17027233
SGTC_79 0052-0007 94.094 µM -1.14311232304261 0.136162429341328 no 2937 0.126495979250061 4231 2801472
SGTC_584 0986-0246 15.4 µM -1.14350268251664 0.136078099955248 no 2938 0.126414970798568 4331 53315 YDR232W HEM1
SGTC_3045 9092950 49.47 µM -1.14388645850397 0.135995227657407 no 2939 0.126335363812838 4185 44120432
SGTC_1628 st004252 77.7 µM -1.14549670370672 0.135647889184439 no 2940 0.126001730061441 4258 692968
SGTC_1796 st049173 110.4 µM -1.14582393745571 0.1355773774849 no 2941 0.125934004246068 4198 94134
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.14641999022844 0.135449005717461 no 2942 0.125810707637849 4180 279621
SGTC_1513 0337-0559 19 µM -1.14765498045642 0.135183291273756 no 2943 0.125555511523121 4217 775073
SGTC_937 3122-0005 46.7 µM -1.14785046617666 0.135141264309796 no 2944 0.12551514985019 4260 759535
SGTC_2746 daunorubicin 9.88 µM -1.14790430258533 0.135129691734582 no 2945 0.125504035909911 4188 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.14867323022178 0.134964478627544 no 2946 0.125345374125693 4223 16623 A steroid.
SGTC_607 4491-0986 66.8 µM -1.15009324049449 0.134659737106073 no 2947 0.125052735067073 4262 698981 YDR232W HEM1
SGTC_543 3844-1095 191 µM -1.15029067642866 0.134617403760363 no 2948 0.12501208482283 4238 4230703
SGTC_3176 9106582 49.47 µM -1.15368218117671 0.133891638141835 no 2949 0.124315245931727 4212 17018027
SGTC_3136 9095672 49.47 µM -1.15404858595845 0.133813390552229 no 2950 0.124240125131292 3998 17217380
SGTC_634 1611-4317 11.2 µM -1.15427939997475 0.133764115194628 no 2951 0.124192819636005 4280 2843522
SGTC_2374 9071832 200 µM -1.15535985907166 0.133533619123312 no 2952 0.12397154633045 4168 17381698
SGTC_596 1155-0152 116 µM -1.15617091565571 0.133360774701222 no 2953 0.123805626871581 4236 280313
SGTC_1128 3448-9350 235 µM -1.15681917298098 0.133222735177168 no 2954 0.123673123405609 4288 619386
SGTC_611 3453-1652 23.7 µM -1.15773894152311 0.133027048981888 no 2955 0.123485293626138 4274 1560575
SGTC_802 4112-3352 742 µM -1.15882920881553 0.13279534456055 no 2956 0.123262904503566 4310 704594
SGTC_734 2023-0417 80 µM -1.1630717085698 0.131896371078817 no 2957 0.122400204782246 4250 3935732
SGTC_1547 harmine 94.2 µM -1.16435985519766 0.131624249252491 no 2958 0.122139104639484 4203 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3001 9076041 71.4286 µM -1.16588453087725 0.131302661533941 no 2959 0.121830567064049 4234 16004211
SGTC_2913 7966556 36.57 µM -1.16628855954564 0.131217533994628 no 2960 0.121748898562417 4140 2976516
SGTC_2335 9018011 154.17 µM -1.16766170551007 0.130928501516549 no 2961 0.121471624690241 4253 6458208
SGTC_2710 st078562 53.7235 µM -1.17052636028093 0.130326939513803 no 2962 0.120894606214472 4201 17250908
SGTC_138 0850-0259 40.9225 µM -1.17348388882552 0.12970788337903 no 2963 0.120300906984448 4213 6813004
SGTC_857 0438-0306 1.35 µM -1.17369873001301 0.129662993294787 no 2964 0.120257859565294 4324 4686136
SGTC_844 0330-0132 15.3 µM -1.17681153631488 0.129013793906035 no 2965 0.119635368513963 4303 2828079
SGTC_2644 guaiazulene 100 µM -1.18222426156404 0.127890303493451 no 2966 0.118558364186327 4283 3515 A coloring agent.
SGTC_1263 0774-1208 64.8 µM -1.18542536191128 0.127229076533394 no 2967 0.117924654504827 4320 906585
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.18604614958153 0.127101120987045 no 2968 0.11780203747252 4236 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1340 1486-1359 257 µM -1.18847359425549 0.126601640626619 no 2969 0.117323438526066 4193 4309068
SGTC_2226 7298446 200 µM -1.1892674140138 0.126438598252616 no 2970 0.117167226946021 4267 3283010
SGTC_742 0kpi-0133 140 µM -1.18954024492162 0.126382595398101 no 2971 0.117113572037773 4309 2728852
SGTC_1510 1123-0200 71.5 µM -1.19399672012743 0.125470279700464 no 2972 0.11623962552412 4302 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_871 0574-0004 149 µM -1.19411631114815 0.125445860891028 no 2973 0.116216236806645 4250 9551173
SGTC_1140 3229-1848 2.98 µM -1.19468957521113 0.125328854467284 no 2974 0.116104168481554 4295 2849525
SGTC_669 0108-0021 26.2 µM -1.19626899746561 0.125006879681916 no 2975 0.115795801507848 4263 17201
SGTC_2277 7947813 106.88 µM -1.19777404367586 0.124700604940066 no 2976 0.115502497356889 4321 1246798
SGTC_183 3914-0051 30.55 µM -1.19873137314965 0.124506062875217 no 2977 0.115316207409523 4314 1596232
SGTC_291 SEC14.278 35.5 µM -1.19875326846931 0.124501615938862 no 2978 0.115311949225469 4317 1068044
SGTC_2973 9094665 17.96 µM -1.20026846555524 0.12419414932535 no 2979 0.115017546351793 4297 25237061 YIL048W NEO1
SGTC_3283 9109332 35.8195 µM -1.20040509991921 0.124166449357831 no 2980 0.114991024585828 4132 17027281
SGTC_2074 5212007 75.395 µM -1.20226585140566 0.123789648261812 no 2981 0.114630271490354 4176 758611
SGTC_766 1391-0721 126 µM -1.20527412736492 0.12318216867106 no 2982 0.114048747070837 4319 1020919 YIL115C NUP159
SGTC_1377 2944-0135 198 µM -1.20881362065844 0.12247009611048 no 2983 0.113367228768395 4309 1894137
SGTC_1902 st060212 70.5 µM -1.21356462487864 0.121518840682643 no 2984 0.112457011206543 4295 688944
SGTC_887 0885-0007 9.62 µM -1.21527246269345 0.121178166405296 no 2985 0.112131095513249 4347 5719458
SGTC_2605 digitonin 300 nM -1.21534333215704 0.121164044111624 no 2986 0.112117585725138 4311 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1871 st057448 67.3 µM -1.21720109076758 0.120794257852594 no 2987 0.11176385764545 4331 691747
SGTC_640 3381-0960 37.1 µM -1.21907197389804 0.120422662661432 no 2988 0.111408438035151 4355 1745025
SGTC_3040 9091894 49.47 µM -1.22310173868091 0.119625006561042 no 2989 0.110645636008593 4154 25236966
SGTC_1710 st031758 61.5 µM -1.22394062025718 0.119459427123688 no 2990 0.110487314316206 4342 5394341
SGTC_1407 3909-7909 12.3 µM -1.2252377006453 0.119203726277682 no 2991 0.110242836797094 4319 4411780
SGTC_2199 6590217 200 µM -1.22579119123823 0.119094731209146 no 2992 0.110138631454449 4205 703109
SGTC_22 0964-0034 14.468 µM -1.2258268982053 0.119087702100197 no 2993 0.110131911352096 4322 138402
SGTC_2191 5911152 200 µM -1.22646967752001 0.118961217618265 no 2994 0.110010989665612 4324 2875902
SGTC_2899 9053889 58.44 µM -1.22762665737801 0.118733789175626 no 2995 0.109793575048032 4291 6470052
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.22928638372577 0.118408072098681 no 2996 0.109482225312842 4301 229346 A bile salt which induces apoptosis.
SGTC_3303 9125618 40.5795 µM -1.22980931679491 0.118305578784326 no 2997 0.109384259262302 4321 22695467
SGTC_3174 9107204 49.47 µM -1.23080889041723 0.118109839917701 no 2998 0.10919717482462 4336 3938802
SGTC_2391 6285546 200 µM -1.234435726463 0.117401547902257 no 2999 0.108520291573122 4325 846083
SGTC_284 0988-0104 32.6 µM -1.2344587098409 0.117397069044329 no 3000 0.108516011788208 4292 4666532
SGTC_539 4859-0462 2.54 µM -1.24105255746326 0.116117094294386 no 3001 0.10729316697037 4339 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2810 7959871 45.46 µM -1.24112179202495 0.116103707476964 no 3002 0.107280380175808 4289 2974535
SGTC_309 k408-0051 1.48 µM -1.24498757968953 0.115357977292056 no 3003 0.106568157887965 4228 3640463
SGTC_3096 9117468 49.47 µM -1.24750027804494 0.1148750940959 no 3004 0.106107059176899 4238 41316311
SGTC_2629 bisabolol 100 µM -1.24889393224801 0.11460788635226 no 3005 0.105851935609729 4357 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1146 3579-1023 7 µM -1.24988054274572 0.114418989412889 no 3006 0.105671594054127 4343 X1146
SGTC_2861 9024595 19.48 µM -1.25065810356037 0.114270273485239 no 3007 0.105529621089438 4233 16482810
SGTC_2532 xanthone 78.9 µM -1.25334833850602 0.113756802469226 no 3008 0.105039481898273 4335 7020 An insecticide.
SGTC_2866 9034245 58.44 µM -1.25626123146095 0.113202690541075 no 3009 0.104510636490335 4331 6462273
SGTC_2144 5628481 200 µM -1.25827317490631 0.112821089934838 no 3010 0.104146489510535 4314 2818399
SGTC_372 0155-0182 15.9 µM -1.26084264597929 0.112335080936948 no 3011 0.103682772761209 4226 771486
SGTC_957 1187-1561 14.1 µM -1.26380875223881 0.11177591180891 no 3012 0.103149339510575 4291 1538454
SGTC_3277 9138724 49.47 µM -1.26405531752833 0.111729519206754 no 3013 0.103105086376367 4298 15943418
SGTC_1984 st072354 53.1 µM -1.26593941942738 0.111375469882475 no 3014 0.102767386039588 4212 5762938
SGTC_858 0438-0351 2.77 µM -1.26813468366708 0.110963962553038 no 3015 0.102374928699291 4313 2799119
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.27092297319515 0.110442862898527 no 3016 0.101878026335201 4251 17037758
SGTC_945 3381-0768 11.3 µM -1.27098803777817 0.110430724050355 no 3017 0.101866452142182 4354 1126236 YIL048W NEO1
SGTC_1047 2043-3044 82 µM -1.27259099409394 0.11013196870221 no 3018 0.10158160800398 4326 669592
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.27347768685197 0.109966958202256 no 3019 0.101424292745128 4346 688751
SGTC_657 3534-0529 86.7 µM -1.27352073383264 0.109958951823678 no 3020 0.101416659955128 4380 1049549
SGTC_2075 5212009 200 µM -1.27356241652524 0.109951199589892 no 3021 0.101409269469905 4267 780898
SGTC_503 tyrphostin 8 294 µM -1.27358765079147 0.109946506659207 no 3022 0.101404795538077 4368 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3342 9147791 14.508 µM -1.27505766290675 0.10967336988239 no 3023 0.101144416520998 4309 1838168
SGTC_2103 5378138 10 µM -1.27515163163525 0.109655926527801 no 3024 0.10112778869449 4417 244142
SGTC_3299 9121982 43.1275 µM -1.27929856991981 0.108888115577969 no 3025 0.100395968009337 4369 17594604 YPL160W CDC60
SGTC_1696 st025591 34.7925 µM -1.28574276755376 0.10770264661366 no 3026 0.0992664250569042 4358 2787147
SGTC_1606 st000094 49.2 µM -1.28960300657278 0.106996988772541 no 3027 0.0985942656494035 4378 1242210
SGTC_3105 9121040 49.47 µM -1.29040335849025 0.106851101520553 no 3028 0.0984553233260901 4278 41448907
SGTC_3181 9108277 49.47 µM -1.29155502932669 0.106641428173517 no 3029 0.0982556431569482 4316 17097298
SGTC_3100 9120536 49.47 µM -1.29393168315891 0.106209673371598 no 3030 0.0978445097484371 4230 16421196
SGTC_3234 9132280 49.47 µM -1.29413229638528 0.106173286842927 no 3031 0.0978098637968986 4372 17612295
SGTC_3043 9092303 49.47 µM -1.29428217299773 0.106146108622048 no 3032 0.0977839859400225 4383 25236084
SGTC_893 0958-0369 48.9 µM -1.29609202604534 0.105818311461114 no 3033 0.0974718909240952 4270 6819948
SGTC_2220 6782180 200 µM -1.30376411872395 0.104436881601357 no 3034 0.0961570100394423 4292 833803
SGTC_956 1185-0240 191 µM -1.30425448046338 0.104349033902324 no 3035 0.0960734149558566 4342 1416193
SGTC_564 3555-0129 330 µM -1.30497898474325 0.104219337885212 no 3036 0.0959500019203938 4263 563260
SGTC_1779 st039427 55 µM -1.30621152914163 0.103998964398903 no 3037 0.0957403165958792 4357 1124498
SGTC_2819 7996655 46.38 µM -1.30828009543402 0.103629873666162 no 3038 0.0953891619123401 4336 6456960
SGTC_2396 5342950 42.78 µM -1.30870015094065 0.103555040126957 no 3039 0.0953179702911219 4354 1886677
SGTC_1329 1447-1697 50.6 µM -1.30958927495042 0.103396770678989 no 3040 0.0951674092983118 4381 2840515
SGTC_472 calcifediol 10 µM -1.31042047114227 0.103248971604458 no 3041 0.0950268160493967 4422 5283731 A vitamin D metabolite.
SGTC_2851 9015922 71.43 µM -1.3112681760696 0.103098395093686 no 3042 0.0948835880617173 4393 2996893
SGTC_1792 st045773 43.6 µM -1.31827510316606 0.101859869631825 no 3043 0.0937057860846717 4341 2919270
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.322321334649 0.101149619667539 no 3044 0.0930305857025467 4219 88881 An O-methylated flavonoid and antioxidant.
SGTC_171 k064-0041 9.68 µM -1.32375880529719 0.100898166009251 no 3045 0.0927915807265365 4370 53325
SGTC_537 1334-0398 209 µM -1.32593607864051 0.10051816868272 no 3046 0.0924304356120651 4407 5846986
SGTC_84 0443-0269 128.823 µM -1.32845440416115 0.100079951367665 no 3047 0.0920140184516273 4310 6150058
SGTC_2504 purpurogallin 52.29 µM -1.33208252866836 0.0994510712222939 no 3048 0.0914165353978063 4296 5281571 An antioxidant.
SGTC_1117 retinoic acid 1.10837 µM -1.33295517160435 0.099300243704909 no 3049 0.0912732576967424 4427 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2406 ethylparaben 405.7 µM -1.33301526318694 0.0992898636399691 no 3050 0.0912633974967956 4367 8434 A possible steroid mimic.
SGTC_266 formosanin C 406 nM -1.33391122978337 0.0991351907671075 no 3051 0.0911164753975114 4228 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3111 9122088 49.47 µM -1.33410350317709 0.0991020211254525 no 3052 0.0910849689588813 4280 16876704
SGTC_465 cgp-37157 41 µM -1.33526625806846 0.0989016038573002 no 3053 0.0908946089581015 4414 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1988 st071872 53.4 µM -1.33772323968407 0.0984790839479947 no 3054 0.0904933361771833 4407 16414116
SGTC_2738 aclarubicin 5.55 µM -1.33832254618583 0.0983762237645246 no 3055 0.0903956576253624 4411 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2161 5662504 8.5105 µM -1.34140325980332 0.0978487162033629 no 3056 0.0898947798925682 4354 2859334
SGTC_715 0868-0130 184 µM -1.34183107731316 0.0977756256931104 no 3057 0.0898253866228165 4443 2876258
SGTC_1745 st081495 74 µM -1.34261447291205 0.0976418901816703 no 3058 0.0896984207539147 4251 13842402 YBL026W LSM2
SGTC_1976 st070609 63.5 µM -1.34351014193383 0.0974891525752783 no 3059 0.0895534221285324 4346 682556
SGTC_1173 0443-0020 122 µM -1.34630665083767 0.0970133943181008 no 3060 0.0891018209097036 4396 5331295
SGTC_1891 st059073 26.2 µM -1.34909176908977 0.0965412700063441 no 3061 0.088653745850084 4474 688754
SGTC_139 0099-0334 718.624 µM -1.35136143993288 0.0961577727046019 no 3062 0.0882898397750832 4422 97690
SGTC_3287 9117173 37.0625 µM -1.35349942271532 0.0957975516561117 no 3063 0.087948067166976 4418 2789709
SGTC_2357 9067248 200 µM -1.35372623100137 0.095759395858639 no 3064 0.0879118681221723 4353 9150235
SGTC_2041 5107442 45.335 µM -1.35379036772108 0.0957486082116872 no 3065 0.087901633792219 4436 793005
SGTC_2420 aureobasidin a 50 nM -1.35616461247358 0.0953498946627389 no 3066 0.0875233993084386 4474 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_813 k007-0158 173 µM -1.35746010685795 0.0951328547685679 no 3067 0.0873175304613943 4405 6523916
SGTC_147 4466-0538 29.23 µM -1.35759102683554 0.0951109414254621 no 3068 0.087296745911575 4477 6742687 YHR072W ERG7
SGTC_2707 st078556 66.6 µM -1.36426251043809 0.0939991866637926 no 3069 0.0862424802421458 4342 17250899
SGTC_164 4100-3994 89.624 µM -1.36518344827761 0.0938464753512873 no 3070 0.086097699621789 4406 4615967
SGTC_1880 MG-132 525 µM -1.36522936940825 0.0938388654356445 no 3071 0.0860904851240874 4367 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_133 0724-0033 378.92 µM -1.36592669986753 0.0937233618379039 no 3072 0.0859809857081879 4245 280309
SGTC_1872 amphotericin b 148 nM -1.37243372300993 0.0926506147935078 no 3073 0.0849642290022746 4422 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_319 1348-1596 45.5 µM -1.3740528680263 0.0923850993496469 no 3074 0.0847126350442205 4487 5380505
SGTC_2167 5876490 200 µM -1.37718284842912 0.0918734266485781 no 3075 0.0842278616237268 4467 686534
SGTC_2219 9098279 200 µM -1.37802113427825 0.0917367451158442 no 3076 0.0840983815471006 4367 902349
SGTC_1267 0828-0272 9.49 µM -1.37984053428567 0.0914406124464259 no 3077 0.0838178745898377 4475 745334
SGTC_2953 9074162 66.49 µM -1.38441214929226 0.0906996464313897 no 3078 0.0831161454690539 4405 16451992
SGTC_2938 9059746 27.26 µM -1.39821742593601 0.0884891453551753 no 3079 0.0810238927049658 4427 6471769
SGTC_572 0960-0087 17.7 µM -1.40014184579893 0.088184222344861 no 3080 0.080735423130503 4389 6796365
SGTC_856 0433-0016 11.3 µM -1.40050996882622 0.0881259828522377 no 3081 0.0806803301482369 4459 3911780
SGTC_3058 9093861 49.47 µM -1.40093666413195 0.0880585127247504 no 3082 0.0806165068207433 4445 17217477
SGTC_371 0195-0006 7.36 µM -1.40145051496586 0.087977312473678 no 3083 0.0805396977488613 4284 3928593
SGTC_1078 idebenone 36.1 µM -1.40181684279987 0.0879194583496722 no 3084 0.0804849737887517 4464 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1243 0416-0003 5.65 µM -1.40464626093305 0.0874735641330939 no 3085 0.0800632465468705 4438 2141977
SGTC_2828 7998861 71.43 µM -1.40580649247091 0.0872912094383872 no 3086 0.0798907968119304 4428 2988188
SGTC_2130 NSC 7 2.4545 µM -1.40756834611973 0.0870148401636905 no 3087 0.0796294629932333 4494 21448
SGTC_146 3448-8650 53.125 µM -1.40980168784669 0.0866654519424527 no 3088 0.0792991240566649 4422 2891488 YIL048W NEO1
SGTC_863 0466-0191 129 µM -1.40991089906139 0.0866483936614961 no 3089 0.0792829970090265 4493 765160 YPR165W RHO1
SGTC_259 usnic acid 108.925 µM -1.41003881613739 0.0866284168036749 no 3090 0.0792641108537572 4484 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1892 st058411 7.36 µM -1.41039134365047 0.0865733802660414 no 3091 0.0792120800014295 4439 3934738
SGTC_1220 1838-0075 193 µM -1.41356913024334 0.0860784439653897 no 3092 0.0787442252050705 4371 5529645
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.41365470029686 0.0860651458665792 no 3093 0.0787316560283677 4463 390807
SGTC_51 1013-0126 23.419 µM -1.41923070401577 0.0852019111951785 no 3094 0.0779158836029864 4444 1627850
SGTC_639 0833-0042 114 µM -1.42073212984347 0.0849705841998859 no 3095 0.0776973240704715 4469 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1223 0764-0573 147 µM -1.42273924757325 0.0846620802383867 no 3096 0.0774058793176541 4444 1609797
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.42667091270271 0.084060199494083 no 3097 0.0768373867954395 4506 368090
SGTC_2096 5468907 200 µM -1.43108625587855 0.0833881107056854 no 3098 0.0762027479129194 4451 759785
SGTC_3139 9095020 49.47 µM -1.43291081164578 0.0831115653279058 no 3099 0.0759416635634007 4325 25236292
SGTC_1402 3909-7673 35.9 µM -1.4334801034404 0.0830254198884755 no 3100 0.0758603404727551 4475 5328014
SGTC_2769 toremifene 3.73 µM -1.43561677300067 0.0827026972684641 no 3101 0.075555709635841 4461 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2545 solidagenone 89.61 µM -1.43759448199762 0.0824048261859592 no 3102 0.0752745737428996 4370 6708572 An anti ulcer agent
SGTC_2201 6605497 169.863 µM -1.43921560372653 0.0821612652473192 no 3103 0.0750447228828448 4403 670741
SGTC_185 k048-0037 25.491 µM -1.44229563473602 0.0817000089820922 no 3104 0.0746094955674258 4505 6827589
SGTC_219 mitoxanthrone 164.414 µM -1.4459718911165 0.0811520225279972 no 3105 0.0740925429915149 4413 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_621 3584-0052 32.1 µM -1.44680884277902 0.0810276541493119 no 3106 0.0739752347199115 4479 2273927
SGTC_1656 st012921 11 µM -1.44750575553717 0.0809242049180158 no 3107 0.0738776628142693 4370 6732821
SGTC_2122 5258151 111.688 µM -1.44950971769385 0.0806272937481073 no 3108 0.0735976442513342 4470 2173356
SGTC_1388 3346-4487 254 µM -1.44995749840925 0.0805610622364546 no 3109 0.0735351858131255 4536 3345614
SGTC_1337 1486-1011 40.3 µM -1.45032607486205 0.0805065767162975 no 3110 0.0734838055541141 4453 X1337
SGTC_2960 9079389 5.97 µM -1.45954227590941 0.0791532080441049 no 3111 0.0722079568457899 4442 16457355
SGTC_1048 3161-0300 24.5 µM -1.46043622132508 0.0790228571887221 no 3112 0.0720851120275579 4476 2165101
SGTC_1699 st031318 29.054 µM -1.46471971296223 0.0784005139737644 no 3113 0.0714987021811281 4525 5340658
SGTC_910 3454-3003 490 µM -1.46808455291481 0.0779142521999994 no 3114 0.0710406284847498 4391 820824
SGTC_2603 homopterocarpin 100 µM -1.46856552368743 0.0778449332180345 no 3115 0.0709753358803984 4450 101795 A weak amylase inhibitor.
SGTC_1873 rapamycin 2 nM -1.46985027642056 0.0776600002132852 no 3116 0.0708011544999037 4444 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_642 0335-0876 158 µM -1.47177935364761 0.0773829469383258 no 3117 0.0705402353512718 4511 6812350
SGTC_2257 7960413 200 µM -1.47546714675671 0.0768553978982123 no 3118 0.0700434972770158 4524 2974689 YIL048W NEO1
SGTC_3183 9108214 49.47 µM -1.47555221091692 0.076843261576332 no 3119 0.070032071146776 4466 4974831
SGTC_1747 st037496 66.6 µM -1.48255209353788 0.0758495553195964 no 3120 0.0690967266414348 4441 723305
SGTC_2048 5246248 200 µM -1.48293142045865 0.0757959867622838 no 3121 0.0690463161994406 4495 677046
SGTC_819 1013-0258 27.7 µM -1.48310497732013 0.0757714866681515 no 3122 0.0690232609091508 4485 5753198
SGTC_1194 1488-0194 225 µM -1.48948928195059 0.0748744345250235 no 3123 0.0681792868173645 4465 1391452
SGTC_50 0929-0078 56.389 µM -1.49173333498853 0.0745610566614049 no 3124 0.067884533265869 4338 1377751
SGTC_1561 5-methoxyflavone 52.9 µM -1.49367389132012 0.0742908696050523 no 3125 0.0676304379131576 4453 94525
SGTC_2898 9056270 58.44 µM -1.49549182005132 0.0740384350993608 no 3126 0.0673930665726181 4506 19154699
SGTC_2827 7993847 71.43 µM -1.49703309615846 0.0738249298659098 no 3127 0.0671923232859684 4525 2985692
SGTC_467 ro 31-8220 72.8 µM -1.49859216007179 0.0736094396280431 no 3128 0.066989733915904 4466 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_609 0986-0026 86.3 µM -1.49911398030362 0.0735374223512792 no 3129 0.0669220326848962 4485 2848610
SGTC_2076 5212012 200 µM -1.49938329551101 0.0735002747971535 no 3130 0.0668871123018657 4476 604802
SGTC_1244 0416-0015 52.5 µM -1.50201656350856 0.0731378149972337 no 3131 0.0665464156055855 4473 96201
SGTC_3214 9129694 49.47 µM -1.50605654920457 0.0725843865988946 no 3132 0.0660263287778527 4506 17158655
SGTC_2011 4012611 177 µM -1.50752819984826 0.0723835874895929 no 3133 0.0658376605832412 4468 2049887
SGTC_562 3772-2733 112 µM -1.50976102864363 0.072079742692483 no 3134 0.0655522062609051 4489 2876874 YIL048W NEO1
SGTC_1579 chlormadinone acetate 49.4 µM -1.51290553267995 0.0716534958773751 no 3135 0.0651518281768442 4522 45114258 A steroidal progestin.
SGTC_2507 purpurin 79.67 µM -1.51299341271493 0.0716416113158744 no 3136 0.0651406660551005 4494 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2608 thymoquinone 42.66 µM -1.51388082561293 0.0715216856971714 no 3137 0.0650280340485024 4461 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_663 1486-0733 13.9 µM -1.5185645389149 0.0708912759356111 no 3138 0.0644360713889176 4518 722445 YPR165W RHO1
SGTC_2186 6124449 200 µM -1.52299998937992 0.0702982248793572 no 3139 0.0638793540417131 4520 3834182 YLR033W RSC58
SGTC_3253 9135987 49.47 µM -1.52649504702856 0.0698336044599714 no 3140 0.0634433115079402 4515 4182430
SGTC_2742 clothiapine 36.27 µM -1.52901600597721 0.0694999469621892 no 3141 0.0631302380074034 4554 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1790 st045711 43.5 µM -1.53077050381727 0.0692684586524147 no 3142 0.0629130609579479 4499 585119
SGTC_2045 5106652 78.05 µM -1.53162847041529 0.0691554750778926 no 3143 0.0628070713827541 4509 673349
SGTC_251 melphalan 456.522 µM -1.53966897492902 0.0681035306500961 no 3144 0.0618205315165557 4551 460612 A DNA alkylator.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.53974638267602 0.0680934637156918 no 3145 0.0618110930033819 4505 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_785 1270-0111 65.3 µM -1.53975535901677 0.0680922964103113 no 3146 0.0618099985693045 4435 6741994
SGTC_1379 2144-0755 36.5 µM -1.54062844045653 0.0679788325631771 no 3147 0.0617036209930612 4560 5392327
SGTC_3201 9113999 49.47 µM -1.54210098385132 0.0677877947060974 no 3148 0.0615245279636175 4492 16649224
SGTC_1799 st045822 46.1415 µM -1.55803168130265 0.065747475380521 no 3149 0.0596128690870396 4513 3674992
SGTC_376 3970-0862 59.1 µM -1.5601034342351 0.0654856716875621 no 3150 0.0593677200713418 4539 3135186
SGTC_1933 st074711 15.9 µM -1.56100823516993 0.0653715875776358 no 3151 0.0592609039122823 4503 17250958
SGTC_2282 7944268 200 µM -1.56279088919572 0.0651472682975575 no 3152 0.0590508939235937 4511 2970414
SGTC_2038 4100038 30.985 µM -1.56401548797225 0.06499351800972 no 3153 0.0589069656130787 4484 3596803
SGTC_2462 5162487 171.77 µM -1.56466196174801 0.0649124658850453 no 3154 0.0588310959959497 4493 2259986
SGTC_1004 4084-0029 199 µM -1.57695066246578 0.0633866385715827 no 3155 0.0574034389598333 4533 716894 YLR208W SEC13
SGTC_2061 5245884 80.95 µM -1.57726045326986 0.0633485372942141 no 3156 0.0573678039795893 4508 573863
SGTC_568 1193-0097 7.48 µM -1.58032130237494 0.0629730400910504 no 3157 0.0570166519110745 4323 3646150
SGTC_1605 st000082 49.1 µM -1.58096746934143 0.0628939920582803 no 3158 0.0569427379973446 4491 1114022
SGTC_2439 5492030 7.2 µM -1.58438482041641 0.0624772195314192 no 3159 0.0565530870623987 4549 5722370
SGTC_1800 st050079 29.0735 µM -1.58903031201939 0.0619141226292959 no 3160 0.0560267747103853 4361 3645560
SGTC_2890 9046729 58.44 µM -1.59025277732007 0.0617666034310991 no 3161 0.0558889191768126 4520 903329
SGTC_2278 7948257 134.34 µM -1.59128121295074 0.0616427111179784 no 3162 0.0557731514487621 4544 1247028
SGTC_3337 9144342 33.5465 µM -1.59334995283624 0.0613940845213232 no 3163 0.0555408531694042 4541 17682949
SGTC_2379 9035213 200 µM -1.59340194501171 0.0613878460710861 no 3164 0.0555350248351188 4551 646551
SGTC_184 1494-0393 24.714 µM -1.59837056199114 0.060793952010166 no 3165 0.0549802660502099 4525 3090647
SGTC_1661 st013063 9.66 µM -1.5991276070215 0.060703858916055 no 3166 0.0548961258108202 4611 721395
SGTC_2430 5571206 200 µM -1.60132661994088 0.0604427547592504 no 3167 0.0546522980105485 4527 1731771
SGTC_1460 k062-0059 9.15 µM -1.60265739257481 0.0602851701769932 no 3168 0.0545051575905918 4434 1373085
SGTC_1279 0874-0590 65.2 µM -1.61607365812572 0.0587143797852344 no 3169 0.0530391943732883 4619 3523074
SGTC_1983 st071813 46.9 µM -1.6212493723791 0.0581170592007684 no 3170 0.0524820840132849 4618 11838595
SGTC_1161 k007-0610 110 µM -1.62302086512214 0.0579137145368259 no 3171 0.0522924723058192 4495 5843850
SGTC_80 0159-0065 512.242 µM -1.62385677854018 0.0578179567990314 no 3172 0.0522031894262739 4521 1548079
SGTC_2356 9061756 188.97 µM -1.62593170421435 0.057580802440152 no 3173 0.0519820923806603 4589 20104043
SGTC_2102 5377816 72.7585 µM -1.62596303087663 0.0575772278197714 no 3174 0.0519787600278275 4590 1379702
SGTC_1519 esterone 74 µM -1.63802859925448 0.0562133818235031 no 3175 0.0507078639891959 4562 698 A steroid.
SGTC_2060 5238662 140 µM -1.64158740143855 0.0558160104824926 no 3176 0.0503377701765614 4531 790130
SGTC_2477 5967686 25.23 µM -1.64378369827413 0.0555718828629427 no 3177 0.0501104449144062 4561 776118
SGTC_3306 9127676 59.7925 µM -1.64570971786684 0.05535849204325 no 3178 0.0499117686618097 4528 41905287
SGTC_2433 5607874 27.82 µM -1.64756628931115 0.0551534086241622 no 3179 0.0497208514073671 4532 2252428
SGTC_1257 0669-0121 16 µM -1.6511387400042 0.0547604720817376 no 3180 0.0493551242328105 4552 4307855
SGTC_1985 st071382 65.5 µM -1.65326032156716 0.0545281671584379 no 3181 0.0491389472890876 4560 6123237
SGTC_1886 st057356 49.9 µM -1.66665942463498 0.0530789723877807 no 3182 0.0477910726937533 4560 24207747
SGTC_1332 1480-0653 17.5 µM -1.66891792363004 0.0528377374062377 no 3183 0.0475668234732802 4580 5749438
SGTC_1137 ixabepilone 100 µM -1.67085413475714 0.0526316198128948 no 3184 0.0473752463641795 4532 154225 A novel microtubule stabilizer.
SGTC_3064 1327-0027 10 µM -1.67275038794208 0.0524303748815094 no 3185 0.0471882226270252 4554 16000455 YPR107C YTH1
SGTC_182 3448-4371 550.524 µM -1.67407833776766 0.052289806711487 no 3186 0.0470576022368524 4514 3491403
SGTC_792 4534-1957 155 µM -1.67726638490492 0.0519535622347269 no 3187 0.0467452013906202 4555 1717904
SGTC_2457 5731572 11.68 µM -1.67746827543575 0.0519323267453583 no 3188 0.0467254740304437 4618 2865357
SGTC_2662 daunorubicin 22.37 µM -1.68246453928772 0.0514089977617814 no 3189 0.0462393977925292 4466 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2135 5326629 150.42 µM -1.68641498924604 0.0509981881383593 no 3190 0.0458579481792528 4541 5020077
SGTC_487 nimodipine 119 µM -1.68742474014705 0.050893603947069 no 3191 0.0457608549952672 4601 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1515 3460-0031 42.1 µM -1.68888850596068 0.0507422987479293 no 3192 0.0456203991798471 4553 2876596
SGTC_575 k072-0246 11.9 µM -1.69292785302345 0.0503266209099887 no 3193 0.0452346004397507 4652 6796779
SGTC_2780 5215298 71.43 µM -1.69293903827042 0.0503254736468607 no 3194 0.045233535790592 4590 2834131
SGTC_3069 9117009 49.47 µM -1.7016172757287 0.0494416156659291 no 3195 0.0444135684370867 4598 41904981
SGTC_1658 st012944 20 µM -1.71226572753686 0.0483740750520365 no 3196 0.0434238547925768 4437 24207260
SGTC_3044 9093193 49.47 µM -1.71271229731097 0.0483297110241085 no 3197 0.0433827408281387 4591 25236277
SGTC_2795 7780010 54.55 µM -1.71693845371862 0.0479114772451093 no 3198 0.0429952089602936 4558 953673
SGTC_869 0564-0080 44.1 µM -1.71966774694771 0.0476429209828834 no 3199 0.0427464268971642 4589 6843321
SGTC_73 0327-0325 16.231 µM -1.72191957373848 0.0474222552133995 no 3200 0.0425420443348334 4414 53298
SGTC_3261 9137475 49.47 µM -1.72345230199624 0.0472725258159569 no 3201 0.0424033818462741 4630 17027690
SGTC_2775 cyproheptadine 69.59 µM -1.72479083725996 0.0471420769167046 no 3202 0.0422825868058044 4589 2913 A selective serotonin reuptake inhibitor.
SGTC_2069 5228469 200 µM -1.73250420481748 0.0463959726801505 no 3203 0.0415919145419828 4601 2835210
SGTC_397 arbidol 50 µM -1.73404102675601 0.0462484564247234 no 3204 0.0414554019894246 4613 131410 A RNA synthesis inhibitor.
SGTC_3322 9139058 2.11 µM -1.74090383824703 0.045594300123326 no 3205 0.0408502179090752 4636 4908926 YPR165W RHO1
SGTC_2650 prasterone 100 µM -1.74106467384329 0.0455790591137431 no 3206 0.0408361213450559 4628 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_76 0433-0009 400.328 µM -1.74677032691451 0.0450410283166946 no 3207 0.0403385928453619 4644 2841569
SGTC_1814 st052110 31.539 µM -1.75377498009302 0.044387507068293 no 3208 0.0397345359135562 4554 674163
SGTC_1522 st012842 45.6 µM -1.75389785413608 0.044376111706101 no 3209 0.0397240056835416 4451 3491067 YOR116C RPO31
SGTC_1878 temozolomide 1 mM -1.75550918576531 0.0442268945569887 no 3210 0.0395861254155558 4589 5394 DNA alkylating agent.
SGTC_3132 9126706 49.47 µM -1.75554183272961 0.044223875474619 no 3211 0.0395833358707393 4615 850858
SGTC_1481 3346-2004 36 µM -1.76297927287579 0.0435404038926314 no 3212 0.0389519927730032 4683 2770522
SGTC_1945 st075991 56.6 µM -1.76345882424712 0.0434966292135468 no 3213 0.0389115680398582 4595 1084980
SGTC_1631 benzylvanillin 81.9 µM -1.76766137585703 0.043114527494514 no 3214 0.0385587653539045 4613 75506
SGTC_421 streptovitacin 30 mM -1.77023463031639 0.042881905154155 no 3215 0.0383440313139749 4586 91467 include heat shock
SGTC_1475 4092-1048 11.7 µM -1.77213922161097 0.0427103840265443 no 3216 0.038185724826616 4620 2881759
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.77392455900736 0.0425501065207976 no 3217 0.0380378149120015 4597 756377
SGTC_1973 st070275 50.2 µM -1.7748912562607 0.0424635250861431 no 3218 0.0379579221542456 4612 17118334
SGTC_2954 9074818 52.69 µM -1.77665243836284 0.0423061525766137 no 3219 0.037812721090307 4605 16648742
SGTC_406 estrone 100 µM -1.77808811623573 0.0421782152681468 no 3220 0.0376946919550615 4606 5870 A steroid.
SGTC_922 1866-0035 480 µM -1.78589455240478 0.0414880311199808 no 3221 0.0370581665981394 4568 3156169
SGTC_1121 fusaric acid 630.51 nM -1.78623547026804 0.0414580996225038 no 3222 0.0370305700984151 4593 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_74 000s-0487 160.283 µM -1.78781512911906 0.0413196389383495 no 3223 0.0369029195845049 4505 677548
SGTC_1970 st070122 35.8 µM -1.79282536684274 0.0408829582924378 no 3224 0.0365004260147511 4630 102928
SGTC_939 1165-0479 45.3 µM -1.79478719149621 0.0407129934557516 no 3225 0.0363438061534635 4597 1377347
SGTC_1832 st054113 55 µM -1.79894129712948 0.0403549904264151 no 3226 0.0360139835494067 4643 1251267
SGTC_1974 st069448 26.9 µM -1.80158849917193 0.0401281897465748 no 3227 0.035805086029252 4619 6323587 YNR016C ACC1
SGTC_2328 6201408 200 µM -1.81013806420957 0.0394027647760979 no 3228 0.0351371897137874 4564 2890418
SGTC_1346 1488-2224 62.4 µM -1.81585777656544 0.0389234342635498 no 3229 0.0346960958701285 4641 3722427
SGTC_55 0767-0285 6.563 µM -1.81649587432526 0.0388702552718322 no 3230 0.0346471701185358 4591 3116166
SGTC_2393 9031399 185.94 µM -1.81857419243633 0.0386974585839014 no 3231 0.0344882090488131 4612 1526623 YDL150W RPC53
SGTC_264 promethazine 12.5 mM -1.82141475155374 0.0384622999587767 no 3232 0.0342719172342468 4496 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1707 st032323 6.317 µM -1.82456586444839 0.0382027959213432 no 3233 0.0340332842917813 4445 3132057 YMR211W DML1
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.83976846045199 0.0369708042846865 no 3234 0.0329011188602825 4674 77254
SGTC_2891 9063876 19.48 µM -1.84563522314923 0.0365041420181899 no 3235 0.0324725942694864 4664 6472478
SGTC_208 k072-0098 12.366 µM -1.86471017136015 0.0350200642505645 no 3236 0.0311110201427211 4659 5948901
SGTC_3297 9117502 71.43 µM -1.86821325047819 0.0347529726257665 no 3237 0.030866176286381 4666 7453720
SGTC_1359 1582-0056 520 nM -1.87589921268835 0.0341728166779975 no 3238 0.030334560395516 4697 3661189
SGTC_2241 6772625 37.8075 µM -1.88075755238642 0.0338102210298713 no 3239 0.0300024533877838 4455 2285411
SGTC_445 e6 berbamine 66 µM -1.88607097064467 0.0334172912066902 no 3240 0.0296426957882914 4657 6610268 A calcium/calmodulin antagonist.
SGTC_865 0488-0499 301 µM -1.88763754164825 0.0333021628377131 no 3241 0.0295373132794313 4604 9634651
SGTC_1273 0849-0096 14.1 µM -1.89702807584567 0.032618875166623 no 3242 0.028912116354007 4663 5286025
SGTC_1284 0929-0043 16 µM -1.90381210739642 0.0321324733679749 no 3243 0.0284673295653433 4660 1239883
SGTC_2289 7946404 165.07 µM -1.90461846322946 0.032075059453845 no 3244 0.0284148423964965 4630 1246120 YPR165W RHO1
SGTC_349 k015-0014 24 µM -1.90618028075734 0.0319640962760253 no 3245 0.0283134098658462 4649 2196908
SGTC_1698 5-fluorocytosine 1.055 µM -1.90632383260107 0.0319539132088561 no 3246 0.028304102005259 4662 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2843 9000894 45.46 µM -1.90873105576834 0.0317835519761704 no 3247 0.0281483973810067 4677 2242070
SGTC_3332 9141069 11.198 µM -1.91138294575697 0.0315967448228779 no 3248 0.0279776933510809 4608 17332883
SGTC_2886 9058944 51.95 µM -1.91356378448413 0.0314438007438404 no 3249 0.0278379580919335 4645 4949929
SGTC_1249 0481-0015 10.2 µM -1.91762468302048 0.0311606374423831 no 3250 0.0275793090197349 4612 4227577
SGTC_2576 guaiol 23.12 µM -1.92162744375663 0.0308835956463506 no 3251 0.0273263264141607 4590 227829
SGTC_1597 7-benzyloxygramine 47.5 µM -1.92255175471678 0.0308199121913296 no 3252 0.0272681839718908 4560 260807
SGTC_862 0452-0056 10.2 µM -1.92974541694481 0.0303279874287172 no 3253 0.0268191947898155 4639 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_56 0957-0365 83.25 µM -1.93557832457503 0.0299339080331351 no 3254 0.0264596836075297 4618 6752360
SGTC_2634 4'-methoxyflavone 100 µM -1.9386572440323 0.0297276103625738 no 3255 0.0262715440738999 4641 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_255 tunicamycin 200.472 nM -1.94255719281295 0.0294679958903921 no 3256 0.0260348416562529 4595 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1468 k284-1086 134 µM -1.94784284572723 0.0291191437443215 no 3257 0.0257168851560561 4664 15996457
SGTC_1136 pergolide 1.05886 µM -1.95556682279806 0.0286155386417383 no 3258 0.0252581021957971 4620 47811 A dopamine receptor agonist.
SGTC_1309 pyrazolanthrone 13.4 µM -1.95763538720498 0.0284819042969973 no 3259 0.0251364059500086 4690 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_3049 9092223 49.47 µM -1.97382493138731 0.0274538521021624 no 3260 0.0242008264653467 4650 8623917
SGTC_2129 girgensonine 121.053 µM -1.97790711506199 0.0271995708030459 no 3261 0.0239695930743878 4653 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2342 7990637 118.86 µM -1.97807052790148 0.0271894327734544 no 3262 0.0239603754132059 4659 2033102 YER133W GLC7
SGTC_554 4483-2211 187 µM -1.97975054187553 0.0270853884587329 no 3263 0.0238657831444178 4704 747107
SGTC_39 0986-0283 58.349 µM -1.98257858650133 0.0269109963356809 no 3264 0.0237072606136426 4689 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_314 1671-0008 2.74 µM -1.99264753017815 0.0262976845676145 no 3265 0.0231500283305353 4564 3913060
SGTC_1300 1094-0077 113 µM -1.99508580278437 0.0261509366307071 no 3266 0.0230167612576811 4679 5532636
SGTC_2384 9036245 200 µM -2.01290685296343 0.0250990345273722 no 3267 0.0220622147496104 4673 6462766
SGTC_3262 9137218 49.47 µM -2.02162874307553 0.0245972854200893 no 3268 0.0216073601709814 4706 17650664
SGTC_556 4058-0063 51.5 µM -2.02637670428265 0.0243277031043252 no 3269 0.0213630981640681 4689 6615692
SGTC_2196 6573537 42.6665 µM -2.0384067734683 0.0236557400236069 no 3270 0.0207546347325966 4713 2903087
SGTC_1344 1488-0097 29.1 µM -2.04498556388387 0.0232949174680563 no 3271 0.0204281406782932 4718 747966
SGTC_3083 9117465 49.47 µM -2.05873055980773 0.0225559876628534 no 3272 0.0197600285026022 4655 16420915
SGTC_1409 3909-8004 61.9 µM -2.06083584166239 0.0224445720476926 no 3273 0.019659351914266 4731 2119279
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -2.06248145450355 0.0223578065183713 no 3274 0.0195809607057659 4717 688664
SGTC_2776 terbinafine 19.92 µM -2.08235409940701 0.0213321641501037 no 3275 0.0186550688892149 4695 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2053 5265679 138 µM -2.09153907793005 0.0208717334337164 no 3276 0.0182398836049539 4623 764595
SGTC_439 amiodarone 34.4 µM -2.10514995437695 0.0202049249732586 no 3277 0.017639128500656 4592 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_620 0109-0052 432 µM -2.10799495176989 0.0200678524204343 no 3278 0.0175157130506451 4727 493037
SGTC_1818 st052136 56.3 µM -2.1175192099817 0.0196146979941609 no 3279 0.0171079033539375 4428 674169
SGTC_2318 6029776 164 µM -2.12446347525955 0.0192898003880843 no 3280 0.0168157035533728 4687 818325
SGTC_1854 st056233 32.9 µM -2.13157400728527 0.0189618742442868 no 3281 0.0165209412246668 4677 5393174
SGTC_2398 5228213 48.84 µM -2.14926951514934 0.0181663073253117 no 3282 0.0158065207936639 4671 80771 YMR134W ERG29
SGTC_917 harmaline 728.087 nM -2.15415411172008 0.0179517781201326 no 3283 0.0156140440783342 4654 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -2.15834116811108 0.0177696078182415 no 3284 0.0154506580906081 4711 689007
SGTC_2699 st077704 54.6 µM -2.17656230714467 0.016995098344253 no 3285 0.014756620039745 4712 645852
SGTC_2567 aureobasidin a 60 nM -2.17704902744088 0.0169748118697311 no 3286 0.0147384548036148 4727 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_801 0866-0028 10.1 µM -2.179867294915 0.0168577531847407 no 3287 0.0146336499241429 4737 6849771
SGTC_2121 5257820 149.641 µM -2.18563733560073 0.0166202428296798 no 3288 0.0144210744145081 4723 791256
SGTC_110 0850-0284 111.64 µM -2.20734707548645 0.015752096744581 no 3289 0.0136449104069181 4709 3906265
SGTC_1028 k015-0029 4.8 µM -2.20752751865897 0.0157450472232996 no 3290 0.0136386133167016 4723 4588309
SGTC_581 0958-0271 211 µM -2.22695597751435 0.0150016839585645 no 3291 0.0129751080485559 4739 4591145
SGTC_2928 9011484 9.79 µM -2.24941918016172 0.0141799969665187 no 3292 0.0122429197245558 4699 2994751
SGTC_85 0868-0259 160.055 µM -2.25175725345859 0.0140967429591765 no 3293 0.0121688081869254 4713 83173
SGTC_1471 k673-0312 37 µM -2.26564914593576 0.0136107173856339 no 3294 0.0117364367397647 4749 24099884
SGTC_161 4065-0411 162.148 µM -2.29937769180003 0.0124904574493389 no 3295 0.0107417507900876 4724 1906281 YLR208W SEC13
SGTC_1687 st020778 55.3625 µM -2.30056090674609 0.0124526522023631 no 3296 0.0107082314405086 4759 4259299
SGTC_1789 tunicamycin 25 nM -2.3133947572834 0.0120489191745245 no 3297 0.0103504725382425 4695 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1327 1436-0082 2.18 µM -2.35586841042239 0.0107926273749875 no 3298 0.00923973128970028 4757 15992205
SGTC_3133 9127736 49.47 µM -2.35987451435095 0.0106802412252615 no 3299 0.00914055885910023 4732 27243420
SGTC_1305 1181-0477 144 µM -2.37767532541054 0.0101931000822618 no 3300 0.00871107921988037 4762 6252086
SGTC_643 k048-0106 28.4 µM -2.38000673543792 0.0101307559616121 no 3301 0.00865616080471113 4772 6763920
SGTC_1997 st073024 93.8 µM -2.38640205599712 0.0099614439924562 no 3302 0.00850706938317837 4772 686268
SGTC_220 paclitaxel 373.376 µM -2.4005027358666 0.00959684168153903 no 3303 0.00818628418082648 4736 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1470 k295-0292 231 µM -2.40120155976332 0.00957907949570289 no 3304 0.00817066632568086 4783 5045612
SGTC_1372 2752-0194 270 µM -2.44683358371663 0.00847971612294349 no 3305 0.00720586822700449 4729 823334
SGTC_2693 st077581 40.7 µM -2.44896936782427 0.00843109018672602 no 3306 0.00716328158143361 4717 25238761
SGTC_2640 pentamidine 10.38 µM -2.46564396398552 0.00805979682855713 no 3307 0.00683836013099695 4721 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1354 1498-1681 81 µM -2.47060642474153 0.00795210916506996 no 3308 0.00674420886321508 4773 5754243
SGTC_2717 st081029 62.2815 µM -2.47299594596732 0.00790070825134323 no 3309 0.0066992831443756 4759 5292846
SGTC_2772 vinpocetine 57.06 µM -2.50021878634778 0.00733542803437807 no 3310 0.00620583142156185 4742 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1681 tripelennamine 100 µM -2.50166967954552 0.00730632705444647 no 3311 0.00618045969202649 4705 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1215 3852-0577 11.2 µM -2.5028298518914 0.00728313042513836 no 3312 0.00616023794392491 4771 2884876
SGTC_2021 4019055 173 µM -2.55536594131613 0.0062984845423288 no 3313 0.00530381064824578 4625 44827708 YER133W GLC7
SGTC_786 4544-0069 423 µM -2.58439037912277 0.00580667117388314 no 3314 0.00487756546759 4761 748821 YLR208W SEC13
SGTC_2916 7875993 68.79 µM -2.59353942731666 0.00565886770079322 no 3315 0.00474968233100987 4733 1299250
SGTC_141 0443-0274 32.331 µM -2.6296734441306 0.0051072483210573 no 3316 0.00427334609537536 4731 1627241
SGTC_973 1325-0077 65.9 µM -2.68823162393427 0.0043144411655949 no 3317 0.00359157756454242 4785 2835149
SGTC_2636 apigenin dimethyl ether 100 µM -2.70925842682161 0.00405781359901031 no 3318 0.00337168961741291 4755 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2052 5265182 7.135 µM -2.71873620600621 0.00394667379950911 no 3319 0.00327659238373853 4764 1239884
SGTC_1041 0206-0046 107 µM -2.72721875822132 0.00384952487905389 no 3320 0.00319353396783517 4769 50494
SGTC_3061 glucosamine 200 µM -2.74160300558387 0.00368967440479273 no 3321 0.00305700936723299 4735 91431 and experimental redox chemotherapeutic
SGTC_2829 7992743 58.44 µM -2.74690111282472 0.00363231449871421 no 3322 0.00300806352949975 4744 16462845
SGTC_2814 7977482 42.97 µM -2.8069215537378 0.00303620095718298 no 3323 0.00250087102276884 4766 6456762
SGTC_221 trifluoperazine 10.304 µM -2.81449138825193 0.00296764239536476 no 3324 0.00244272433055311 4757 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2620 irigenin 100 µM -2.81467453333081 0.00296600110949626 no 3325 0.00244133280387445 4755 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2619 obliquin 87.91 µM -2.83121789528288 0.00282107631519749 no 3326 0.0023185559537906 4782 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1654 st012436 41.8 µM -2.85769273713384 0.0026024006825192 no 3327 0.00213366694101438 4795 4323132
SGTC_3129 9127257 49.47 µM -2.90307813345551 0.00226289719342646 no 3328 0.00184757217668338 4768 837894
SGTC_798 1287-0182 476 µM -2.90323380663792 0.00226180519520953 no 3329 0.00184665397387972 4796 1649755
SGTC_1855 st056195 39.6 µM -2.9054653024688 0.00224620433685744 no 3330 0.00183353752269812 4763 4028379
SGTC_407 eburnamonine 100 µM -3.0194315950132 0.00156792772338764 no 3331 0.00126624737473417 4752 3195
SGTC_2688 kanamycin b 96.69 µM -3.02795248089034 0.00152562433182764 no 3332 0.00123108400456555 4753 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1453 4237-0541 195 µM -3.03251084059042 0.00150342345174472 no 3333 0.00121264193000929 4789 739892
SGTC_1633 st005664 67.9 µM -3.0559480131332 0.00139385964051204 no 3334 0.0011217507576699 4777 2063822
SGTC_651 3253-0966 34.4 µM -3.1087201167661 0.00117335781311396 no 3335 0.000939498113257818 4795 781462
SGTC_658 3253-0951 102 µM -3.1544903548093 0.0010084925558767 no 3336 0.000803893463681686 4794 1184878
SGTC_1712 st032288 53.4 µM -3.1640136098532 0.00097698166947132 yes 3337 0.000778047593028794 4719 2883011
SGTC_2771 fluoxetine 41.05 µM -3.18358571512451 0.000915040056662895 yes 3338 0.000727315193147605 4796 3386 A selective serotonin reuptake inhibitor.
SGTC_310 1273-0058 1.06 µM -3.21189573417434 0.000831811990794967 yes 3339 0.000659311113846628 4534 2734232
SGTC_1315 1237-0019 3.69 µM -3.32334852229138 0.000567395326855275 yes 3340 0.000444718568333797 4801 825140
SGTC_2910 7948405 25.97 µM -3.38297920403327 0.000460220001458701 yes 3341 0.000358520308456546 4797 2971328
SGTC_687 k029-0044 34.9 µM -3.42334540052858 0.000398669676529986 yes 3342 0.000309277128620774 4804 5829338
SGTC_2602 kawain 100 µM -3.42386311175576 0.000397932387656831 yes 3343 0.000308688555349261 4793 5369129
SGTC_807 1315-0151 48 µM -3.6357281488854 0.000182733197144804 yes 3344 0.00013859826895091 4797 4011080
SGTC_1846 st056244 14.8 µM -3.68483093701722 0.000151674894497449 yes 3345 0.000114427248309201 4794 5393182
SGTC_135 0933-0004 26.348 µM -3.71407263666931 0.000135604308417926 yes 3346 0.000101975106244185 4793 21230617 YGL099W LSG1
SGTC_2692 st077426 47.7 µM -3.76701018279467 0.000110495043715555 yes 3347 8.2607132327084e-05 4802 25238571
SGTC_1754 st042065 16.137 µM -4.22755618003156 1.66689855894678e-05 yes 3348 1.18121600013049e-05 4781 1126236 YIL048W NEO1
SGTC_1463 k081-0032 34.1 µM -4.46471892566807 5.82546283461538e-06 yes 3349 4.0086966425992e-06 4583 977755
SGTC_1250 0485-0349 40.2 µM -5.11143478885742 2.53215263796797e-07 yes 3350 1.59860595190539e-07 4804 6842794 YDL195W SEC31
SGTC_1462 k081-0014 26.5 µM -5.39293161146757 5.71560941938543e-08 yes 3351 3.46586699860522e-08 4605 3270634